bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying cancer drug regimens in French health insurance database: An application in multiple myeloma patients
Authors: Palmaro Aurore , Gauthier Martin , Despas Fabien , Lapeyre‐Mestre Maryse 
Published: July 2017

AbstractPurposeThere is no consensus on how to handle complex drug combinations of cancer drugs through medico‐administrative databases. Our objective was to develop an algorithm for identifying the nature and patterns of treatment lines in a cohort of newly treated multiple myeloma patients.MethodsA cohort of multiple myeloma patients starting a first treatment line was built using both ambulatory and hospital data from regional data of the French national healthcare system database (SNIIRAM). Patients were identified from January 2011 to September 2013 using ICD‐10 codes for multiple myeloma (‘C90’) within long‐term conditions or diagnosis from hospital data. Drugs of interest for cycle identification included bortezomib, imids (thalidomide, lenalidomide), alkylating drugs (cyclophosphamide, melphalan, bendamustine, doxorubicin) and dexamethasone. An algorithm was applied to define combinations of treatment received in the first 6 months of treatment.ResultsAmong the 236 patients included, 45% received bortezomib‐melphalan‐prednisone (VMP: n = 107), 22% bortezomib‐thalidomide‐dexamethasone (VTD/VTD‐PACE: n = 52) and 21% melphalan‐prednisone‐thalidomide (MPT: n = 49). Other drug regimens consisted in melphalan‐prednisone (MP: 7%, n = 17), lenalidomide‐dexamethasone (RD) (4%, n = 9), bortezomib‐cyclophosphamide‐dexamethasone (VCD: n = 1) and bortezomib‐bendamustine‐dexamethasone (VBD: n = 1). Type of drug regimens and allocation by age class (±65 years) were in accordance with current recommendations.ConclusionsThis study demonstrates the feasibility of identifying complex drug regimens in onco‐haematology, using both outpatient and inpatient drug records in French health insurance databases.
A comparative study between epoxy/Titania micro‐ and nanoparticulate composites thermal and mechanical behavior by means of particle–matrix interphase considerations
Authors: Papanicolaou George C. , Kostopoulos Vassilis , Kontaxis Lykourgos C. , Kollia Evgenia , Kotrotsos Athanasios 
Published: July 2017

The aim of the present study is to examine and compare the thermal and mechanical properties of epoxy resin/TiO2particle microcomposites (0.2 μm) and nanocomposites (21 nm). Composite materials consisting of epoxy resin reinforced with different amounts of TiO2microparticles (1, 5, 10, 15, and 20% wt) and TiO2nanoparticles (0.5%, 1%, 3%wt) were prepared. The thermal and mechanical properties of the manufactured composites were investigated and compared through differential scanning calorimetry (DSC) and three‐point bending tests (3PB). Lipatov's Theory was then applied on the DSC results, thus leading to the calculation of the particle‐matrix interphase thickness which was correlated to experimental findings. The glass transition temperature (Tg) of the materials was obtained and the effect of the grain size on the measuredTgvalues was investigated. The data obtained from DSC tests for both micro‐ and nanoinclusions when normalized with respect to the specific surface area of the particles, resulted in a single continuous curve describing the normalized phase transition enthalpy variation with filler weight fraction. POLYM. ENG. SCI., 58:1146–1154, 2018. © 2017 Society of Plastics Engineers
Flexible Ti‐Doped FeOOH Quantum Dots/Graphene/Bacterial Cellulose Anode for High‐Energy Asymmetric Supercapacitors
Authors: Liu Rong , Ma Lina , Niu Gudan , Li Xiaolong , Li Enyuan , Bai Yang , Liu Yang , Yuan Guohui 
Published: July 2017

AbstractTi‐doped FeOOH quantum dots (QD) decorated on graphene (GN) sheets are designed and fabricated by a facile and scalable synthesis route. Importantly, the Ti‐doped FeOOH QD/GN are successfully dispersed within bacterial cellulose (BC) substrate as bending anode with large loading mass for flexible supercapacitor. By virtue of its favorable architecture, this composite electrode exhibits a remarkable areal capacitance of 3322 mF cm−2 at 2 mA cm−2, outstanding cycle performance (94.7% capacitance retention after 6000 cycles), and excellent mechanical strength (68.7 MPa). To push the energy density of flexible supercapacitors, the optimized asymmetric supercapacitor using Mn3O4/GN/BC as positive electrode and Ti‐doped FeOOH QD/GN/BC as negative electrode can be cycled reversibly in the operating voltage range of 0–1.8 V and displays ultrahigh areal energy density of 0.541 mWh cm−2, ultrahigh volumetric energy density of 9.02 mWh cm−3, reasonable cycling performance (9.4% decay in specific capacitance after 5000 cycles), and good capacitive retention at bending state.
Anti‐myocardial Ischemia Effect and Components of Litchi Pericarp Extracts
Authors: Chen Yanfen , Li Huanqing , Zhang Shu , Yang Chaoyan , Mai Ziying , Hu Xueyan , Gao Zhenhu , Deng Hong 
Published: July 2017

Litchi (Litchi chinensis Sonn.) is a famous fruit in south China, and it is also effective for chest tightness or chest pain, irritability, flatulence, epigastric pain and neuralgic pain, hernia pain and testicular swelling, cough, etc. It is valued because a great amount of polyphenol was found in litchi pericarp. In this paper, we got litchi pericarp pure extract by a simple purification method, then evaluated its activity to clear oxygen free radicals in vitro, and evaluated its myocardial protection effect in vivo through acute myocardial ischemia rat model. The results showed that the pure extract had protective effect on myocardial ischemia injury in a certain dose–effect relationship, which reflected in the electrocardiogram, myocardial pathological morphology and other indicators such as cardiac function enzymes, serum and myocardial antioxidant capacity, and eNOS, Bcl‐2 and Bax gene expression. Furthermore, we analyzed the components of pure extract by UPLC‐MS, ESI‐MS and NMR. The main components of PLPE were procyanidin which were identified as procyanidin B2(1), (−)‐epicatechin(2), epicatechin‐(4β → 8,2β → O → 7)‐epicatechin‐(4β → 8)‐epicatechin(3), A‐type procyanidin trimer(4), B‐type procyanidin dimer(5) and procyanidin A2(6).This study proved that litchi pericarp extract may have antioxidant activity and cardioprotection effect. It suggested that litchi pericarp may be good for cardiovascular disease. Copyright © 2017 John Wiley & Sons, Ltd.
Quantifying streambank movement and topography using unmanned aircraft system photogrammetry with comparison to terrestrial laser scanning
Authors: Hamshaw Scott D. , Bryce Thomas , Rizzo Donna M. , O'Neil‐Dunne Jarlath , Frolik Jeff , Dewoolkar Mandar M. 
Published: July 2017

AbstractStreambank movement is an integral part of geomorphic changes along river corridors and affects a range of physical, ecological, and socio‐economic systems including aquatic habitat, water quality, and infrastructure. Various methods have been used to quantify streambank erosion, including bank pins, ground surveys, lidar, and analytical models, however, due to high‐cost or labour intensive fieldwork these are typically feasible or appropriate only for site‐specific studies. Advancements in unmanned aircraft systems (UAS) and photogrammetry provide opportunities for more rapid and economical quantification of streambank erosion and deposition at variable scales. This work assesses the performance of UAS‐based photogrammetry for capturing topography of streambank surfaces and quantifying bank movement. UAS data are compared to terrestrial laser scanner (TLS) and GPS surveying from streambank sites located in Vermont that featured a variety of bank conditions and vegetation. Cross‐sectional analysis of data from UAS and TLS revealed that the UAS reliably captured the bank surface within 0.2 m of TLS and GPS surveys across all sites during leaf‐off conditions. Mean error between UAS and TLS was only 0.11 m in early spring conditions. Dense summer vegetation resulted in decreased accuracy and was a limiting factor in the ability of the UAS to capture the ground surface. At areas with observed bank movement, the change in cross‐sectional area estimated using UAS data compared reliably to TLS survey for net cross‐sectional changes greater than 3.5 m2, given a 10% error tolerance. At locations with smaller changes, error increased due to the effect of vegetation, georeferencing, and overhanging bank profiles. UAS‐based photogrammetry shows significant promise for capturing bank topography and movement at fine resolutions in a flexible and efficient manner.
On the interest of architectural technical debt: Uncovering the contagious debt phenomenon
Authors: Martini Antonio , Bosch Jan 
Published: July 2017

AbstractA known problem in large software companies is to balance the prioritization of short‐term and long‐term business goals. As an example, architecture suboptimality (Architectural Technical Debt), incurred to deliver fast, might hinder future feature development. However, some technical debt generates more interest to be paid than other. We conducted a multi‐phase, multiple‐case embedded case study comprehending 9 sites at 6 large international software companies. We have investigated which architectural technical debt items generate more interest , how the interest occurs during software development and which costly extra‐activities are triggered as a result. We presented a taxonomy of the most dangerous items identified during the qualitative investigation and a model of their effects that can be used for prioritization, for further investigation and as a quality model for extracting more precise and context‐specific metrics. We found that some architectural technical debt items are contagious, causing the interest to be not only fixed, but potentially compound, which leads to the hidden growth of interest (possibly exponential). We found important factors to be monitored to refactor the debt before it becomes too costly. Instances of these phenomena need to be identified and stopped before the development reaches a crises.
Development and validation of an instrument to assess student attitudes toward science across grades 5 through 10
Authors: Summers Ryan , Abd‐El‐Khalick Fouad 
Published: July 2017

AbstractThe aim of the present study is to enable future studies into students’ attitudes toward science, and related constructs, by developing and validating an instrument suitable for cross‐sectional designs. Following a thorough review of the literature it was determined that many extant instruments included design aspects that appeared to be limited in some way. The BRAINS (Behaviors, Related Attitudes, and Intentions toward Science) Survey was designed to address core criticisms that have been leveled against many existing instruments. BRAINS was rooted in a theoretical framework drawn from the theories of reasoned action and planned behavior (TRAPB). Initial development involved review by an expert panel, adaptation for online delivery and a pilot on this platform. To establish the psychometric validity of the 59‐item instrument it was administered to a representative, random sample of 1,291 Illinois students in grades 5 through 10. Confirmatory factor analysis and subsequent refinement yielded a 30‐item instrument with five factors and a good statistical fit including a RMSEA of 0.04 and a CFI of 0.95. The five factors, or constructs, of the final instrument model reflect the underlying TRAPB framework: attitudes toward science, behavioral beliefs about science, intentions to engage in science, normative beliefs, and control beliefs. © 2017 Wiley Periodicals, Inc. J Res Sci Teach 55: 172–205, 2018
Right and left ventricular 24‐segment sphericity index is abnormal in small‐for‐gestational‐age fetuses
Authors: DeVore G. R. , Zaretsky M. , Gumina D. L. , Hobbins J. C. 
Published: July 2017

ABSTRACTObjectiveFetuses with growth restriction have been reported to have an abnormal sphericity index (SI), which is indicative of the shape of the ventricular chambers of the heart. Our aim was to evaluate the SI for 24 transverse segments distributed from base to apex of the right (RV) and left (LV) ventricles to determine whether, in small‐for‐gestational‐age (SGA) fetuses, the SI is abnormal at locations other than the basal segment.MethodsWe evaluated 30 SGA fetuses between 25 and 37 weeks of gestation. SI was computed for both ventricles by dividing the end‐diastolic mid‐basal–apical length by each of 24 end‐diastolic transverse segmental widths, from base (Segment 1) to apex (Segment 24). For each ventricle, the Z‐score and centile for the SI from each of the 24 segments were computed using the mean and SD from published equations. The 24‐segment method, defining abnormal SI as values < 10th centile or > 90th centile, was compared with that of using only the basal segment by chi‐square analysis to determine the number of fetuses identified with an abnormal SI.ResultsIn 23 of the 30 (77%) SGA fetuses, at least one of the 24 transverse segments in one or both ventricles had an abnormal SI; in 17% of cases, both ventricles were affected, in 23% of cases only the RV was involved and in 37% of cases only the LV was involved. Compared with the 24‐segment model, significantly fewer fetuses with an abnormal SI were identified using only basal Segment 1, from the RV base (58%, 7/12; P < 0.01) or only Segment 12, in the mid portion of the RV (50%, 6/12; P < 0.005). Combining measurements of Segment 1 and Segment 12 from the RV identified 83% of fetuses with at least one abnormal SI and was not significantly different from using the 24‐segment model. Similarly, significantly fewer fetuses with an abnormal SI were identified using only LV basal Segment 1 (63%, 10/16; P < 0.006) or only Segment 12, in the mid portion of the LV (75%, 12/16; P < 0.03), when compared with the 24‐segment model. Combining measurements of both LV Segment 1 and Segment 12 identified 81% (13/16) of fetuses with an abnormal SI and was not significantly different from using the 24‐segment model.ConclusionThe 24‐segment SI of RV and LV provides a comprehensive method with which to examine the shape of the ventricular chambers and identifies more SGA fetuses with an abnormal SI than are identified using only the basal segment SI. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy
Authors: Crane Andrés , Brubaker William D. , Johansson Jenny U. , Trigunaite Abhishek , Ceballos Justine , Bradt Bonnie , Glavis‐Bloom Courtney , Wallace Tanya L. , Tenner Andrea J. , Rogers Joseph 
Published: July 2017

AbstractIntroductionOur previous studies have shown that amyloid β peptide (Aβ) is subject to complement‐mediated clearance from the peripheral circulation, and that this mechanism is deficient in Alzheimer's disease. The mechanism should be enhanced by Aβ antibodies that form immune complexes (ICs) with Aβ, and therefore may be relevant to current Aβ immunotherapy approaches.MethodsMultidisciplinary methods were employed to demonstrate enhanced complement‐mediated capture of Aβ antibody immune complexes compared with Aβ alone in both erythrocytes and THP1‐derived macrophages.ResultsAβ antibodies dramatically increased complement activation and opsonization of Aβ, followed by commensurately enhanced Aβ capture by human erythrocytes and macrophages. These in vitro findings were consistent with enhanced peripheral clearance of intravenously administered Aβ antibody immune complexes in nonhuman primates.DiscussionTogether with our previous results, showing significant Alzheimer's disease deficits in peripheral Aβ clearance, the present findings strongly suggest that peripheral mechanisms should not be ignored as contributors to the effects of Aβ immunotherapy.
Sudden failure of ventricular pacing and recovery in a patient with cardiac sarcoidosis
Authors: Terui Yosuke , Nakamura Akihiro , Endo Hideaki , Kadosaka Takahide , Nakata Takashi , Watanabe Tasuku , Sato Kenjiro , Kanazawa Masanori , Kondo Masateru , Takahashi Tohru , Nozaki Eiji 
Published: July 2017

AbstractA 76‐year‐old woman with sarcoidosis who had an implantable pacemaker for complete atrioventricular block was admitted with syncope. Electrocardiogram revealed ventricular pacing failure, and a marked rise in the ventricular pacing threshold. 18F‐Fluorodeoxyglucose positron emission tomography (FDG‐PET) indicated increased uptake of FDG in the ventricular septum. Three days after steroid therapy, the ventricular pacing threshold reverted to normal, and FDG‐PET showed decreased FDG uptake in the ventricular septum. In this case report, we demonstrate that a sudden deterioration in the ventricular pacing threshold due to worsening cardiac sarcoidosis can be reversed with early steroid therapy.
Behavioral inhibition, maladaptive pain cognitions, and function in patients with chronic pain
Authors: Jensen Mark P. , Solé Ester , Castarlenas Elena , Racine Mélanie , Roy Rubén , Miró Jordi , Cane Douglas 
Published: July 2017

Abstract

Background and aims
Trait behavioral inhibition represents a tendency to react with negative emotions - primarily worry - to cues which signal potential threats. This tendency has been hypothesized by a two-factor model of chronic pain to have direct effects on psychological and physical function in individuals with chronic pain, as well as to influence the associations between pain-related maladaptive cognitions and function. Our aim was to test these hypothesized associations in a sample of individuals who were being screened for possible interdisciplinary chronic pain treatment.

Methods
Eighty-eight patients referred to an interdisciplinary chronic pain management program were administered measures of average pain intensity, trait behavioral inhibition, kinesiophobia, pain catastrophizing, depressive symptoms, and pain interference. We then performed two linear regression analyses to evaluate the direct effects of trait behavioral inhibition on depressive symptoms and pain interference and the extent to which behavioral inhibition moderated the associations between kinesiophobia and pain catastrophizing, and the criterion variables.

Results
In partial support of the study hypotheses, the results showed significant (and independent) direct effects of trait behavioral inhibition on depressive symptoms, and behavioral inhibition moderated the association between kinesiophobia and depression, such that there were stronger associations between kinesiophobia and depressive symptoms in those with higher dispositional sensitivity to fear-inducing stimuli. However, neither direct nor moderating effects of behavioral inhibition emerged in the prediction of pain interference.

Conclusions
If replicated in additional studies, the findings would indicate that chronic pain treatments which target both reductions in maladaptive cognitions (to decrease the direct negative effects of these on depressive symptoms) and the individual’s tendency to respond to pain with worry (as a way to buffer the potential effects of maladaptive cognitions on depressive symptoms) might be more effective than treatments that targeted only one of these factors.

Implications
Additional research is needed to further evaluate the direct and moderating effects of pain-related behavioral inhibition on function, as well as the extent to which treatments which target behavioral inhibition responses provide benefits to individuals with chronic pain.
Freshwater Catfish Envenoming in a Tropical Country
Authors: Thalgaspitiya Sujeewa P.B. , Wijerathne Buddhika T.B. , Siriwardhana Nuwan P. 
Published: July 2017

Objective Freshwater catfish are known to cause painful stings in humans. Stings usually cause mild envenomation and, in some instances, can lead to severe secondary bacterial infections. Sri Lanka is a tropical country where catfish stings are not rare. However, presenting signs and symptoms, complications, and management options are scarce in the literature. Methods A retrospective, descriptive, cross-sectional study was conducted by reviewing patient records in the university surgical units and surgical clinic in the teaching hospital in Anuradhapura, Sri Lanka, during 2015. Results Ten patients presented to the hospital following catfish stings. The common presenting features following stings were severe pain, swelling, and lymphadenopathy followed by cellulitis. Late complication such as tenosynovitis were also observed. Conclusions Routine procedures are sufficient to reduce further complications. However, people who are at high risk of encountering catfish, and travelers visiting tropical countries, should be aware of the possibility of stings and take necessary precautions.
SALAFI THOUGHT IN TURKISH PUBLIC DISCOURSE SINCE 1980
Authors: Hammond Andrew 
Published: July 2017

AbstractTurkey has been absent from the growing literature on the phenomenon of transnational Salafism. A tendency among Middle East specialists to focus on Arab regions and in Turkey on the Islamist movement and its long struggle with the Kemalist establishment has perpetuated the notion of Turkey as a category apart. This article argues that, on the contrary, Salafism is a fringe strand of Turkish Islam that began to evolve in the context of the state's effort in the 1980s to recalibrate religion as a complement to nationalism. Salafism became a topic of discussion in media and scholarly writing in Turkish religious studies faculties, while self-styled Salafi preachers trained in Saudi Arabia found a niche through publishing houses. These publishers facilitated the translation into Turkish of Arabic texts by important Saudi religious scholars in an effort to change the discursive landscape of Islam in Turkey. I show that contra assumptions of a rich Sufi tradition acting as a block against modern Salafi ideas, Salafism managed to gain a foothold in Turkey, facilitated in part by the republic's experience of secular materialism.
Intermediate input linkage and carbon leakage
Authors: Zhang Zengkai , Zhang Zhongxiang 
Published: July 2017

AbstractClimate regulations tend to target energy-intensive sectors whose products are widely used in industrial production as intermediate inputs, and carbon abatement may be partially offset by intermediate input-led leakage. This paper aims to examine the impact of intermediate input linkages on carbon leakage both theoretically and empirically. The theoretical part develops a Harberger-type model with an input-output linkage structure, identifies four leakage effects and derives closed-form solutions for these leakage effects. Its empirical part builds a computable general equilibrium model of China's economy and introduces structural decomposition analysis to link the theoretical and empirical models. When imposing a carbon price on the electricity generation sector, our results show significant sectoral carbon leakage. Our decomposition analysis further suggests that such leakage is mainly through the production substitution effect and the multiplier effect. Our results highlight the importance of sectoral linkage when discussing the carbon leakage issue of climate policies.