bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modular Polyoxometalate–Layered Double Hydroxides as Efficient Heterogeneous Sulfoxidation and Epoxidation Catalysts
Authors: Li Tengfei , Zhang Wei , Chen Wei , Miras Haralampos N. , Song Yu‐Fei 
Published: August 2017

AbstractThe selective sulfoxidation of sulfides and the epoxidation of olefins are two types of important organic reactions, and the corresponding products of sulfoxides, sulfones and epoxides are used widely as raw materials in industrial processes. The fabrication of one efficient catalyst for both reactions remains a challenging task. We report the preparation of a highly efficient heterogeneous catalyst Mg3Al‐ILs‐La(PW11)2 using an exfoliation/assembly approach. The catalyst was characterised by FT‐IR spectroscopy, XRD, thermogravimetric and differential thermal analysis, BET measurements, X‐ray photoelectron spectroscopy, 29Si cross‐polarisation magic‐angle spinning NMR spectroscopy, 27Al magic‐angle spinning NMR spectroscopy, SEM, high‐resolution TEM, and energy‐dispersive X‐ray spectroscopy. The designed catalyst showed a high efficiency and selectivity for the sulfoxidation of sulfides and the epoxidation of olefins under mild conditions at a production rate of 208 and 31 mmol g−1 h−1, respectively. Moreover, Mg3Al‐ILs‐La(PW11)2 can be recycled and re‐used at least five times without a clear decrease of its catalytic activity. The scaled‐up experiments revealed that the catalyst retained its efficiency and robustness, which demonstrates the great potential of the catalyst for industrial applications.
Potential‐Driven On/Off Switch Strategy for the Electrosynthesis of [7]Helicene‐Derived Polymers
Authors: Hrbáč Jan , Strašák Tomáš , Fekete Ladislav , Ladányi Vít , Pokorný Jan , Bulíř Jiří , Krbal Miloš , Žádný Jaroslav , Storch Jan , Vacek Jan 
Published: August 2017

AbstractNew materials bearing thiophene and helicene moieties were prepared by using a potential‐driven on/off switch strategy on the surface of glassy carbon and indium tin oxide substrates. Specifically, a 3‐([7]helicen‐9‐yl)‐thiophene hybrid monomer was electrooxidized in acetonitrile by using cyclic voltammetry with anodic potential limits of +1.5 or +2.5 V, resulting in a conductive and non‐conductive polymer, respectively. The electrochemical findings were supplemented by microscopy investigations, UV/Vis, fluorescence and vibrational spectroscopies, and 1H NMR spectroscopy as well as ellipsometry measurements and computational chemistry. The electrodeposited polymers could be used for the further development of materials applicable in organic electronics, optoelectronics, and sensing technologies.
Modular Bi‐Directional One‐Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β‐Carboline‐Benzoxazepines
Authors: Srinivasulu Vunnam , Mazitschek Ralph , Kariem Noor M. , Reddy Amarnath , Rabeh Wael M. , Li Liang , O'Connor Matthew John , Al‐Tel Taleb H. 
Published: August 2017

AbstractThe development of robust and efficient strategies to access structurally diverse drug‐like compound collections remains an important challenge for small molecule probe development and drug discovery. Following a build/couple/pair strategy we have established bidirectional approach to unprecedented benzoxazepines by employing a Pictet–Spengler/aza‐Michael addition cascade and Schiff base/aza‐Michael addition/reduction protocols, respectively. The corresponding β‐carboline‐fused benzoxazepines and peripherally substituted benzoxazepines are isolated in high diastereoselectivity, good to excellent yields and have, to the best of our knowledge, never been reported.
In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent
Authors: Lesniak Wojciech G. , Aboye Teshome , Chatterjee Samit , Camarero Julio A. , Nimmagadda Sridhar 
Published: August 2017

AbstractThe CXCR4 chemokine receptor plays a key regulatory role in many biological functions, including embryonic development and controlling leukocyte functions during inflammation and immunity. CXCR4 has been also associated with multiple types of cancers where its overexpression/activation promotes metastasis, angiogenesis, and tumor growth and/or survival. Furthermore, CXCR4 is involved in HIV replication, as it is a co‐receptor for viral entry into host cells. Altogether, these features make CXCR4 a very attractive target for the development of imaging and therapeutic agents. Here, the in vivo evaluation of the MCoTI‐based cyclotide, MCo‐CVX‐5c, for the development of imaging agents that target CXCR4 is reported. Cyclotide MCo‐CVX‐5c is a potent CXCR4 antagonist with a remarkable in vivo resistance to biological degradation in serum. A [64Cu]‐DOTA‐labeled version of this cyclotide demonstrated high and significant uptake in U87‐stb‐CXCR4 tumors compared to the control U87 tumors. Furthermore, protracted imaging studies demonstrated radiotracer retention in the U87‐stb‐CXCR4 tumor at 24 h post injection. Uptake in U87‐stb‐CXCR4 tumors could be blocked by unlabeled MCo‐CVX‐5c, showing high in vivo specificity. These results demonstrate the in vivo specificity and retention of a bioactive molecularly targeted cyclotide and highlight the potential of bioactive cyclotides for the development of new imaging agents that target CXCR4.
Kinetic Studies on Formic Acid Dehydrogenation Catalyzed by an Iridium Complex towards Insights into the Catalytic Mechanism of High‐Pressure Hydrogen Gas Production
Authors: Iguchi Masayuki , Zhong Heng , Himeda Yuichiro , Kawanami Hajime 
Published: August 2017

AbstractKinetic studies on the catalytic reaction mechanism of formic acid (FA) dehydrogenation were performed in the presence of a water‐soluble iridium complex bearing a 4,4′‐dihydroxy‐2,2′‐bipyridine ligand. Determination of kinetic isotope effects revealed that a shift of the rate‐limiting step at low and high concentrations of FA can be caused by the pH dependence of the reaction steps. The proposed equation for the reaction rate corresponds well with the experimental results concerning the shift phenomena. Towards industrial application in future hydrogen fueling stations, this will able the design of a dehydrogenation system catalyzed by the iridium complex.
Regiodivergent Remote Arylation of Cycloalkanols to Dysideanone′s Fused Carbotetracycles and Its Bridged Isomers
Authors: Haque Md Ashraful , Jana Chandan K. 
Published: August 2017

AbstractRegiodivergent γ and γ′ arylations across an all‐carbon quaternary center of cycloalkanols to access enantioenriched fused and bridged carbotetracycles are reported. The conformation of the carbocation guided either sequential stereospecific β‐C‐Me/γ‐C−H‐shifts or β‐C‐Me/γ′‐C−H‐shifts, providing fused carbotetracyclic analogs of dysideanone or bridged tetracycles, respectively. The reaction is highly stereoselective in building three contiguous stereocenters, where one, two, or three could be all‐carbon quaternary centers. Interestingly, mechanistic studies revealed a crucial role of a methyl substituent in controlling regioselectivity.
Amorphous Transition Metal Sulfides Anchored on Amorphous Carbon‐Coated Multiwalled Carbon Nanotubes for Enhanced Lithium‐Ion Storage
Authors: Jin Rencheng , Zhai Qinghe , Wang Qingyao 
Published: August 2017

AbstractCobalt sulfide and molybdenum sulfide, with high theoretical capacities, have been considered as one of most promising anode materials for lithium‐ion batteries (LIBs). However, the poor cyclability and low rate performances originating from the large volume expansion and poor electrical conductivity extremely inhibit their practical application. Here, the electrochemical performances are effectively improved by growing amorphous cobalt sulfide and molybdenum sulfide onto amorphous carbon‐coated multiwalled carbon nanotubes (CNTs@C@CoS2 and CNTs@C@MoS2). The CNTs@C@CoS2 presents a high reversible specific capacity of 1252 mAh g−1 at 0.2 Ag−1, excellent rate performance of 672 mAh g−1 (5 Ag−1), and enhanced cycle life of 598 mAh g−1 after 500 cycles at 2 Ag−1. For CNTs@C@MoS2, it exhibits a specific capacity of 1395 mAh g−1, superior rate performance of 727 mAh g−1 at 5 Ag−1, and long cycle stability (796 mAh g−1 after 500 cycles at 2 Ag−1). The enhanced electrochemical properties of the electrodes are probably ascribed to their amorphous nature, the combination of CNTs@C that adhered and hindered the agglomeration of CoS2 and MoS2 as well as the enhanced electronic conductivity.
N‐Heterocyclic Carbene Catalyzed [3+2] Cycloaddition of Enals with Masked Cinnamates for the Asymmetric One‐Pot Synthesis of Adipic Acid Derivatives
Authors: Chen Xiang‐Yu , Li Sun , Sheng He , Liu Qiang , Jafari Ehsan , von Essen Carolina , Rissanen Kari , Enders Dieter 
Published: August 2017

AbstractA novel short entry to 3,4‐disubstituted adipic acids has been developed by employing an asymmetric NHC‐catalyzed [3+2] cycloaddition of enals with masked cinnammates in moderate to good yields and high stereoselectivities. The synthetic utility of the protocol was demonstrated by the basic conversion of the masked cyclopentanone intermediates to 3S,4S‐disubstituted adipic acid precursors of pharmaceutically important gababutins.
Synthesis and cytotoxicity of (R)‐ and (S)‐ricinoleic acid amides and their acetates
Authors: Matysiak Sylwia , Chmiel Agnieszka , Skolimowski Janusz , Kula Jozef , Pasternak Beata , Blaszczyk Alina 
Published: August 2017

AbstractAn environment‐friendly, free of solvent, process for the synthesis of (R)‐ and (S)‐ricinoleic acid amides has been developed. Starting from methyl ricinoleates and pyrrolidine or ethanolamine, the corresponding amides were obtained with yields ranging from 83–88%. Among 12 synthesized derivatives of ricinoleic acid, including the starting methyl esters, amides, and their acetates, nine compounds were obtained and tested for the first time. Studies on ricinoleic acid derivatives cytotoxicity showed that methyl esters were the least cytotoxic compounds and modification of their structure resulted in increasing cytotoxicity of the obtained products against both cancer cells and normal lymphocytes. Both enantiomers of the ethanolamine‐derived amides showed the most promising anticancer potential.
Contribution of the cytoskeleton to mechanosensitivity reported by dinoflagellate bioluminescence
Authors: Stires J. C. , Latz M. I. 
Published: August 2017

AbstractThe cytoskeleton is crucial to cell mechanics and sensing the extracellular physical environment. The objective of this study was to examine the role of the cortical cytoskeleton in mechanosensitivity in a unicellular protist, the marine dinoflagellate Lingulodinium polyedra, using its intrinsic bioluminescence as a rapid reporter of mechanotransduction. Pharmacological treatments resolved effects due to immediate cytoskeleton disruption from those due to cytoskeletal remodeling during the light to dark phase transition. The cytoskeleton was visualized by confocal laser scanning microscopy of immunohistochemically labeled microtubules and phalloidin labeled F‐actin, and mechanosensitivity assessed based on the bioluminescence response to mechanical stimulation measured during the dark phase. Latrunculin B treatment after the transition from the light to dark phase resulted in some disruption of cortical F‐actin, no observed effect on the cortical microtubules, and partial inhibition of the bioluminescence response. Treatment with oryzalin, which depolarizes microtubules, completely disrupted the microtubule network and cortical F‐actin, and partially inhibited bioluminescence. These results demonstrate that cells retain some mechanosensitivity despite a disrupted cytoskeleton; link mechanosensitivity to intact F‐actin; show a close connection between F‐actin and microtubules comprising the cortical cytoskeleton; confirm a strong contribution of the actin cytoskeleton to the translocation of scintillons, vesicles containing the luminescent chemistry; and support the role of the actin cytoskeleton in the association of scintillons with the vacuole membrane.
Bridging Pharmaceutical Chemistry with Drug and Nanoparticle Targeting to Investigate the Role of the 18‐kDa Translocator Protein TSPO
Authors: Iacobazzi Rosa Maria , Lopalco Antonio , Cutrignelli Annalisa , Laquintana Valentino , Lopedota Angela , Franco Massimo , Denora Nunzio 
Published: August 2017

AbstractAn interesting mitochondrial biomarker is the 18‐kDa mitochondrial translocator protein (TSPO). Decades of study have shown that this protein plays an important role in a wide range of cellular functions, including opening of the mitochondrial permeability transition pore as well as programmed cell death and proliferation. Variations in TSPO expression have been correlated to different diseases, from tumors to endocrine and neurological disorders. TSPO has therefore become an appealing target for both early diagnosis and selective mitochondrial drug delivery. The number of structurally different TSPO ligands examined has increased over time, highlighting the scientific community′s growing understanding of the roles of TSPO in normal and pathological conditions. However, only few TSPO ligands are characterized by the presence of groups that are potentially derivatizable; therefore only few such ligands are well suited for the preparation of targeted prodrugs or nanocarriers able to deliver therapeutics and/or diagnostic agents to mitochondria. This review provides an overview of the very few examples of drug delivery systems characterized by moieties that target TSPO.
Microphysiological Systems to Assess Nonclinical Toxicity
Authors: Van Ness Kirk P. , Chang Shih‐Yu , Weber Elijah J. , Zumpano Danielle , Eaton David L. , Kelly Edward J. 
Published: August 2017

AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their utility for nonclinical toxicology investigations. We have developed a renal and hepatic microphysiological system (MPS) platform that uses a commercially available MPS device as the core cell culture platform for our methodologies. We describe protocols for isolating and propagating human proximal epithelial cells and how to seed and culture a renal MPS to recapitulate the human proximal tubule. We present two methods to culture hepatocytes within an MPS and the steps required to connect a renal MPS to a liver MPS. © 2017 by John Wiley & Sons, Inc.
Clinicopathological significance of atypical glandular cells on cervicovaginal Pap smears
Authors: Kim Mi‐Kyung , Lee Yoo Kyung , Hong Sung Ran , Lim Kyung Taek 
Published: August 2017

ObjectiveTo evaluate the histologic correlation and clinical significance of atypical glandular cells (AGC) detected on Pap tests.MethodsPap tests interpreted as AGC were retrieved from an institutional cytopathology database. The AGC subcategories according to the Bethesda system 2001 include atypical glandular cells, not otherwise specified (AGC‐NOS), atypical endometrial cells (AEM), and atypical endocervical cells (AEC). Clinicopathologic variables were collected from medical records retrospectively, and histologic follow‐up diagnoses were correlated with AGC subcategories.ResultsFrom January 2009 to December 2014, 741 (0.17%) of 435 778 cervical smears were interpreted as AGC. Of 713 cases included in the study analysis, the distribution of AGC subcategories was as follows: AGC 15.3%, AEM 59.6%, and AEC 25.1%. Of 508 cases with histologic follow‐up results, 33.9% of cases were diagnosed to have clinically significant lesions, which include cervical squamous or glandular neoplasia (1.4% and 10.0%), endometrial neoplasia (21.5%), and other metastatic carcinoma (1.0%). Endometrial neoplasia was the most common significant pathology in women aged ≥40 years (28.4%), whereas cervical glandular neoplasia was the most commonly diagnosed lesion in women aged <40 years (14.5%, P < 0.001). When considering past histories which could affect the Pap results, IUD use (10.3%) and pregnancy (7.3%) were most frequently documented. Although IUD users showed low prevalence of significant pathology (2.6%), AGC cases related with pregnancy preceded significant pathologic lesions in 14.3%.ConclusionsThe relatively high incidence of significant neoplasia linked to AGC emphasizes the importance of adherence to the AGC management guidelines which recommend early and intensive investigation using multiple testing modalities.
FUCCI tracking shows cell‐cycle‐dependent Neurog3 variation in pancreatic progenitors
Authors: Bechard Matthew E. , Bankaitis Eric D. , Ustione Alessandro , Piston David W. , Magnuson Mark A. , Wright Christopher V.E. 
Published: August 2017

AbstractDuring pancreas organogenesis, Neurog3HI endocrine‐committing cells are generated from a population of Sox9+ mitotic progenitors with only a low level of Neurog3 transcriptional activity (Neurog3TA.LO). Low‐level Neurog3 protein, in Neurog3TA.LO cells, is required to maintain their mitotic endocrine‐lineage‐primed status. Herein, we describe a Neurog3‐driven FUCCI cell‐cycle reporter (Neurog3P2A.FUCCI) derived from a Neurog3 BAC transgenic reporter that functions as a loxed cassette acceptor (LCA). In cycling Sox9+ Neurog3TA.LO progenitors, the majority of cells in S‐G2‐M phases have undetectable levels of Neurog3 with increased expression of endocrine progenitor markers, while those in G1 have low Neurog3 levels with increased expression of endocrine differentiation markers. These findings support a model in which variations in Neurog3 protein levels are coordinated with cell‐cycle phase progression in Neurog3TA.LO progenitors with entrance into G1 triggering a concerted effort, beyond increasing Neurog3 levels, to maintain an endocrine‐lineage‐primed state by initiating expression of the downstream endocrine differentiation program prior to endocrine‐commitment.
Group psychotherapy for eating disorders: A meta‐analysis
Authors: Grenon Renee , Schwartze Dominique , Hammond Nicole , Ivanova Iryna , Mcquaid Nancy , Proulx Genevieve , Tasca Giorgio A. 
Published: August 2017

AbstractObjectiveIn the current meta‐analysis, we review the effect of group psychotherapy compared to both wait‐list controls and other active treatments for adults with eating disorders (EDs).MethodTwenty‐seven randomized controlled trials (RCTs) that provide direct comparisons with a total of 1,853 participants were included.ResultsGroup psychotherapy is significantly more effective than wait‐list controls at achieving abstinence rates of binge eating and/or purging (RR = 5.51, 95% CI: 3.73, 8.12), decreasing the frequency of binge eating and/or purging (g = 0.70, 95% CI: 0.51, 0.90), and reducing related ED psychopathology (g = 0.49, 95% CI: 0.32, 0.66) after treatment. The effects of group psychotherapy and other active treatments (e.g., behavioral weight loss, self‐help, individual psychotherapy) did not differ on any outcome at post‐treatment or at follow‐ups. Group cognitive behavioral therapy (CBT) and other forms of group psychotherapy did not differ significantly on outcomes at any time point.DiscussionAdditional research is needed to evaluate other group psychotherapy approaches, along with CBT, to provide more evidence‐based treatment options for individuals with an ED. Group psychotherapy appears as effective as other common treatments and is perhaps more cost‐effective than the most popular treatment, individual psychotherapy. Only 8.33% of comparisons in the current meta‐analysis had at least 80% power to detect a moderate effect (d = .50) and we recommend that future RCTs be adequately powered.
Below‐ and above‐ground effects of deadwood and termites in plantation forests
Authors: Ulyshen Michael D. , Shefferson Richard , Horn Scott , Taylor Melanie K. , Bush Bryana , Brownie Cavell , Seibold Sebastian , Strickland Michael S. 
Published: August 2017

AbstractDeadwood is an important legacy structure in managed forests, providing continuity in shelter and resource availability for many organisms and acting as a vehicle by which nutrients can be passed from one stand to the next following a harvest. Despite existing at the interface between below‐ and above‐ground systems, however, much remains unknown about the role woody debris plays in linking these zones. Moreover, it remains untested whether the accelerative effects of wood‐feeding insects on wood decomposition influence tree growth or nutritional status in forests. In this study, we added different quantities of pine logs to the bases of saplings in two‐year‐old loblolly pine (Pinus taedaL.) plantations in Mississippi,USA. We included a treatment in which subterranean termites (Blattodea: Rhinotermitidae:Reticulitermes) were excluded from logs to determine how these insects affect the release of nutrients from wood and, in turn, tree growth. After 51 months of decomposition, we quantified below‐ground effects by measuring microbial biomass, plant‐available forms of N, and ectomycorrhizal diversity associated with fine tree roots. Meanwhile, above‐ground measurements focused on the elemental concentrations in decomposing wood either protected or unprotected from termites and tree metrics related to growth and nutrient status. We found additions of wood to significantly increase nitrate and potential net nitrification relative to reference treatments but detected no significant effects on tree growth, needle nitrogen concentrations, or ectomycorrhizal diversity. Soil nitrate and potential net nitrification were higher under protected vs. unprotected logs, and plant‐available forms of N were mostly more abundant short distances away from both protected and unprotected logs than directly under them. The wood of logs protected from termites had significantly lower concentrations of most elements compared to that of unprotected logs, largely due to the large amounts of soil imported into unprotected logs by termites. Termite exclusion had no measurable effect on tree growth, nutritional status, or ectomycorrhizal diversity, however. Our findings indicate that deadwood and termites both contribute to the spatial heterogeneity of soil properties but may have limited short‐term local effects on tree growth. Longer‐term studies and studies on less fertile sites are needed.