bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental toxicity evaluation of Pimenta pseudocaryophyllus (Gomes) Landrum, (E)‐methyl isoeugenol chemotype, in Wistar rats
Authors: Cardoso Bruce Soares , Machado Katia Borges , de Paula José Realino , de Paula Joelma Abadia Marciano , Cuvinel Wilson de Melo , Amaral Vanessa Cristiane Santana 
Published: August 2017

BackgroundPimenta pseudocaryophyllus (Gomes) Landrum (Myrtaceae) has been traditionally used in Brazilian folk medicine. Studies have established the botanical characterization, phytochemistry profile, and pharmacological potential of this species, including antibiotic, anxiolytic, antidepressant, antioxidant, antinociceptive, and anti‐inflammatory properties. Despite its widespread use, no previous study has been conducted regarding its toxicological profile, especially during pregnancy. Thus, this study investigated the developmental toxicity of the dry leaf extract of the P. pseudocaryophyllus, (E)‐methyl isoeugenol chemotype, in rats.MethodsFirst, the dry leaf extract was prepared by a spray‐drying technique. Then, pregnant Wistar rats were orally treated with dry extract at doses of 0, 2000, 2500, or 3000 mg/kg from gestational day 6 through 15 (organogenesis period). On gestational day 21, the rats underwent cesarean sections and the reproductive outcomes and biochemistry parameters related to hepatic and renal markers were evaluated. Additionally, the fetuses were examined for external and skeletal variations and malformations.ResultsThe spray‐drying technique preserved the phytocomplex components and showed a satisfactory yield. No relevant differences were seen in the food consumption, reproductive performances, and hepatic and renal biochemical parameters between groups. However, there was a decrease in body weight gain of the dams during the organogenesis period and an increase of minor skeletal variations in the offspring (increased fetal incidences only of delayed ossification of the metacarpals, metatarsals, phalanges, sternebra, and rudimentary ribs) treated with the dry extract.ConclusionThe extract of P. pseudocaryophyllus, (E)‐methyl isoeugenol chemotype, showed low maternal toxicity and induced minor skeletal variations in the offspring. Birth Defects Research 109:1292–1300, 2017. © 2017 Wiley Periodicals, Inc.
Prediction accuracy and variable selection for penalized cause‐specific hazards models
Authors: Saadati Maral , Beyersmann Jan , Kopp‐Schneider Annette , Benner Axel 
Published: August 2017

AbstractWe consider modeling competing risks data in high dimensions using a penalized cause‐specific hazards (CSHs) approach. CSHs have conceptual advantages that are useful for analyzing molecular data. First, working on hazards level can further understanding of the underlying biological mechanisms that drive transition hazards. Second, CSH models can be used to extend the multistate framework for high‐dimensional data. The CSH approach is implemented by fitting separate proportional hazards models for each event type (iCS). In the high‐dimensional setting, this might seem too complex and possibly prone to overfitting. Therefore, we consider an extension, namely “linking” the separate models by choosing penalty tuning parameters that in combination yield best prediction of the incidence of the event of interest (penCR). We investigate whether this extension is useful with respect to prediction accuracy and variable selection. The two approaches are compared to the subdistribution hazards (SDH) model, which is an established method that naturally achieves “linking” by working on incidence level, but loses interpretability of the covariate effects. Our simulation studies indicate that in many aspects, iCS is competitive to penCR and the SDH approach. There are some instances that speak in favor of linking the CSH models, for example, in the presence of opposing effects on the CSHs. We conclude that penalized CSH models are a viable solution for competing risks models in high dimensions. Linking the CSHs can be useful in some particular cases; however, simple models using separately penalized CSH are often justified.
Luminescent properties of single‐phase Ba2‐x‐1.5y‐1.5zP2O7:xEu2+,yCe3+, zTb3+ phosphors for white light‐emitting diode
Authors: Liu Sha‐sha , Zhu Da‐chuan , Zhao Cong , Han Tao 
Published: August 2017

AbstractA series of Ba2P2O7:xEu2+,yCe3+,zTb3+ phosphors was synthesized via a co‐precipitation method, then their crystal structure, quantum efficiency and luminescent properties were analyzed by XRD and FL, respectively. The results showed that these phosphors not only presented the excitation characteristics of Ba2P2O7:xEu2+,zTb3+, but also exhibited that of the Ba2P2O7:yCe3+,zTb3+ phosphor. Meanwhile, the tri‐doped phosphor showed a stronger absorption around 320 nm in contrast with the Eu2+/Ce3+:Tb3+ co‐doped phosphor. Not only can energy transfer from Ce3+→Eu2+ be observed; the energy transfer mechanism from Eu2+ to Tb3+ is discussed in the tri‐doped system. Ce3+ affects the luminescence properties of Ba2P2O7:xEu2+,yCe3+,zTb3+ phosphors just as the sensitizer whereas Eu2+ is considered both as the sensitizer and the activator. The chromaticity coordinates of tri‐doped phosphors excited at 320 nm stayed steadily in the bluish‐white light region,and the emitted color and color temperature (CCT) of these phosphors could be tuned by adjusting the relative contents of Eu2+, Ce3+ and Tb3+. Hence, the single phase Ba2P2O7:xEu2+,yCe3+,zTb3+ phosphors may be considered as potential candidates for white light‐emitting diodes.
Interaction effects of GIT1 and DRD4 gene variants on continuous performance test variables in patients with ADHD
Authors: Kim Hyojin , Kim Johanna Inhyang , Kim Haebin , Kim Jae‐Won , Kim Bung‐Nyun 
Published: August 2017

AbstractIntroductionThe G protein‐coupled receptor kinase interacting protein 1 gene (GIT1) has been proposed to be a risk gene for attention deficit hyperactivity disorder (ADHD), and it regulates the endocytosis of G protein‐coupled receptors like dopamine receptors. The purpose of this study was to investigate the interaction effects of GIT1 and dopamine receptor D4 (DRD4) gene variants on variables of the continuous performance test (CPT).MethodsThis study recruited 255 ADHD patients and 98 healthy controls (HC) who underwent CPT and genetic analyses. The genotypes were classified into two groups (the C/C and C/T genotype groups for GIT1, 4R homozygotes and others for DRD4) and the genotype × genotype effects were examined using hierarchical multivariable linear regression analyses.ResultsThere were significant GIT1 × DRD4 effects for commission errors on the CPT in the ADHD group (p = .006). In contrast, there were no significant GIT1 × DRD4 effects on any CPT variables in the HC.ConclusionsThe present findings demonstrated that there were significant interaction effects of the GIT1 and DRD4 gene variants on impulsivity in ADHD. Replication studies with larger sample sizes that include patients from various ethnic backgrounds are warranted to confirm these findings.
Female Parkinson's disease caregivers have much anxiety and depressive symptom
Authors: Gultekin Murat , Ekinci Ayten , Erturk Gozde , Mirza Meral 
Published: August 2017

AbstractObjectiveParkinson's Disease Caregivers (PDC) play an important role, especially in the medium and advanced phase of the disease for patients’ daily life activities, treatment, and follow‐up. The aim of this study is to attract attention to the factors which place PDC at risk of psychological problems and to give consideration to these factors.Materials and MethodsFirst of all, the 80 participants, who were PDC, filled in the demographic information form. The Hospital Anxiety and Depression Scale (HADS) was applied in order to determine the psychological status of the PDC.ResultsThe average age of PDC in the study was found as 47.94. While 11 (13.8%) of the PDC had undergone psychiatric treatment in the past, four of them (5%) were currently receiving treatment. Twenty‐eight (35%) of those who provide care have experience in patient care, whereas 52 (65%) of them have no prior experience in caring for patients. Thirty‐six (45%) of the PDC reported that they had difficulties, which were mostly psychological. According to the HADS which was applied, anxiety was seen in 26 of those who provide care (32.5%), while depression was seen in 41 (51.3%).ConclusionThis study is the first to provide data on the psychological status of PDC in our country. It is important that PDC's psychological problems are reduced by psychotherapy or, if necessary, by treatment. This situation has a direct negative effect on the patient's daily life activities.
Synthesis of Terminal Ethynyl Aryl Selenides and Sulfides Based on the Retro‐Favorskii Reaction of Hydroxypropargyl Precursors
Authors: Lopes Eric F. , Dalberto Bianca T. , Perin Gelson , Alves Diego , Barcellos Thiago , Lenardão Eder J. 
Published: August 2017

AbstractThe retro‐Favorskii reaction is an excellent way to achieve terminal alkynes. Methodologies that connect the synthesis of terminal alkynes and organochalcogen motifs are important for the construction of novel compounds. Fourteen new terminal alkynes containing either Csp−S or Csp−Se bonds were selectively prepared through the retro‐Favorskii reaction from the respective carbinol precursors. It was discovered that terminal chalcogen alkynes were stable for weeks if stored as a solution in hexanes.
Elucidation of the Conformation of Polyglycine Organo‐Polyoxotungstates: Evidence for Zipper Folding
Authors: Vilona Debora , Lachkar David , Dumont Elise , Lelli Moreno , Lacôte Emmanuel 
Published: August 2017

AbstractThe conformation of a family of α1 and α2 polyglycine‐containing organo‐polyoxometalates was determined through a mixed experimental/molecular dynamics approach. The flexible peptide arm folds around the metal oxide surface in a rigid arrangement in low to average polarity solvents. The topology of the hybrid is the main factor that determines which oxos from the metal‐oxide surface accept a H‐bond from the closest amino acid. The rest of the peptide follows in a zipper mechanism that establishes a H‐bond network that locks the system. The covalent constraint leads to a new type of H‐bond where two consecutive amino acids clamp down terminal oxo ligands.
Modelling simultaneous chain‐end and random scissions using the fixed pivot technique
Authors: Ho Yong Kuen , Doshi Pankaj , Yeoh Hak Koon 
Published: August 2017

AbstractIn this study, for the first time we demonstrated that both random and chain‐end scissions of polymers can be simulated on a unified Fixed Pivot (FP) framework through an elegant implementation of a discrete‐continuous meshing strategy. Achieved using only a fraction of computational expense in solving the full set of exact equations, the FP solutions benchmarked very well against the exact solutions for a polymer with a broad size distribution typical of natural polymers at different degrees of up to ∼O(105). This is attained despite the use of an efficient computational technique to obtain the exact solutions. Moreover, new observations revealed an additional strength of the current meshing strategy, in that the number of the discrete partitions can be adjusted to improve the accuracy of the solution while retaining the total number of equations to be solved. The FP technique, which in the past was reported to over‐predict in cases of pure aggregation, also exhibits marginal over‐prediction for pure random scission. The source of this behaviour is further uncovered, leading to a revised guideline on the choice of the number of discrete pivots.
Instant One‐Pot Preparation of Functional Layered Double Hydroxides (LDHs) via a Continuous Hydrothermal Approach
Authors: Pascu Oana , Marre Samuel , Cacciuttolo Bastien , Ali Ghina , Hecquet Laurence , Pucheault Mathieu , Prevot Vanessa , Aymonier Cyril 
Published: August 2017

AbstractInstant one‐pot synthesis of functional layered double hydroxides (LDHs) is demonstrated for the first time using a continuous hydrothermal multi‐step process. The as‐prepared pristine material displays high crystallinity and very small LDH nanoparticle size, lateral dimensions below 100 nm and a thickness below 20 nm, all being achieved in only 5 s. This approach was extended to the preparation of i) pristine LDH with different compositions by varying the cation (Mg, Ni, or Zn) and the anion (CO3, NO3) and ii) functional LDH by varying the functionalization agent, for example long organic molecules (hybrid LDH), enzymes (bio‐hybrid LDH) or inorganic metal/oxide nanocrystals (inorganic‐LDH). Beyond the design of functional LDH, this paper presents proof of concept for a continuous, one‐pot and multistep high temperature/high pressure (HT/HP) process for the assembly of nanoscaled materials.
Zinc Imidazolate Metal–Organic Frameworks (ZIF‐8) for Electrochemical Reduction of CO2 to CO
Authors: Wang Yulin , Hou Pengfei , Wang Zhuo , Kang Peng 
Published: August 2017

AbstractMetal–organic frameworks (MOFs) are regarded as promising materials for CO2 adsorption, which is an important step in CO2 electrochemical reduction. In this work, zeolitic imidazolate framework (ZIF‐8) nanomaterials were synthesized with various zinc sources and used as electrocatalysts for CO2 reduction to CO. Among them, ZIF‐8, prepared using ZnSO4, delivers the best catalytic activity towards CO2 electroreduction, with 65 % CO yield. The main catalytic center can be attributed to the discrete Zn nodes in ZIF‐8. Electrolytes are important in increasing the CO selectivity, and NaCl is the best suitable electrolyte due to facile anion exchange.
Protein‐Lipid Interaction by Fluorescence (PLIF) to Characterize and Screen for Inhibitors of Protein‐Phosphoinositide Interactions
Authors: Ceccato Laurie , Mansat Mélanie , Payrastre Bernard , Gaits‐Iacovoni Frédérique , Viaud Julien 
Published: August 2017

AbstractPhosphoinositides are key signaling and regulatory phospholipids that mediate important pathophysiological processes. This is achieved through the interaction of their phosphorylated inositol head group with a wide range of protein domains. Therefore, being able to determine the phosphoinositide specificity for effector protein is essential to the understanding of its cellular function. This unit describes a novel method named Protein‐Lipid Interaction by Fluorescence, or PLIF. PLIF is a fast, reliable and high throughput assay that allows determination of the phosphoinositide specificity of proteins, simultaneously providing relative affinities. In addition, PLIF is suitable for screening inhibitors of protein‐ phosphoinositide interaction, allowing identification of potential pharmacological compounds. © 2017 by John Wiley & Sons, Inc.
Hindered Amine Light Stabilizers Increase the Stability of Methylammonium Lead Iodide Perovskite Against Light and Oxygen
Authors: Marinova Nevena , Franckevičius Marius , Matulaitienė Ieva , Devižis Andrius , Niaura Gediminas , Gulbinas Vidmantas , Delgado Juan Luis 
Published: August 2017

AbstractMethylammonium lead iodide perovskite (MAPI) is a promising material for highly efficient photovoltaic devices. However, it suffers from photooxidation, which imposes strict requirements for its protection from oxygen during processing and operation. A hindered amine light stabilizer (HALS) has been found to exert a stabilization effect on methylammonium iodide (MAI) and MAPI against photooxidation. The HALS prevents the degradation of MAI by inhibiting the oxidation of iodide to iodine. Chemical modification of HALS allows its incorporation in MAPI films, which extends the resistivity of MAPI against photodegradation in ambient air from a couple of hours to several days, while causing no significant changes in key properties, such as optical absorption and charge transport. These results represent an important advance in the stabilization of MAPI against decomposition and demonstrate for the first time that antioxidants improve the stability of MAPI.
On fluid‐flow modeling of priority based request scheduling for finite buffer SIP server
Authors: Yavas Demir Y. , Hokelek Ibrahim , Gunsel Bilge 
Published: August 2017

SummaryWith the widespread deployments of voice‐over‐internet protocol services, the existing session initiation protocol (SIP) design cannot scale up for large network sizes. Events triggering a demand burst or a server slowdown can cause SIP server overload, overload propagation, and crash, thus bringing down the whole SIP network. Since the SIP retransmission mechanism exacerbates the overload condition, existing models created for a stable SIP system cannot be effectively used to analyze an overloaded server. In this paper, we propose a fluid‐flow model to characterize the behavior of the finite buffer SIP server equipped with priority‐based request scheduling mechanism (PRSM). The model for the PRSM uses primary and secondary queues for the original request messages and the retransmitted requests, respectively. The performance metrics, namely, the failed call attempts and the response delay from sending INVITE request until receiving a 100‐Trying response, are derived using the arrival time‐slot tracking and the removal processes of the proposed fluid‐flow model. We conducted test cases under the heavy traffic conditions, where the overload is caused by bulk and bursty arrivals or server slowdown. The numerical results closely match with the simulation results for all experiments, indicating that the proposed model can accurately capture the dynamic behavior of an SIP server with the PRSM. The experiments demonstrate that the number of failed call attempts is close to 0 and the mean response delay is kept constant around 175 ms for the PRSM when the buffer size is higher than 1K while both metrics are significantly higher for the conventional SIP.
Fifty years of continuous precipitation and stream chemistry data from the Hubbard Brook ecosystem study (1963–2013)
Authors: Likens Gene E. 
Published: August 2017

AbstractThe Hubbard Brook Ecosystem Study officially began on 1 June 1963. This archive contains the results of 50 yr of collection and analysis of (at least) weekly stream water and precipitation samples obtained during the period 1963–2014 (from 1 June 1963 to 30 May 2013). Stream chemistry for the nine gauged watersheds and precipitation chemistry for precipitation gauges distributed throughout the Hubbard Brook Experimental Forest are reported as concentrations in (mg/L).
Visual Attention to Ambiguous Emotional Faces in Eating Disorders: Role of Alexithymia
Authors: Fujiwara Esther , Kube Veronica L. , Rochman Daniel , Macrae‐Korobkov Alexander K. , Peynenburg Vanessa ,   The University of Alberta Hospital Eating Disorder Program
Published: August 2017

AbstractEating disorders (EDs) are often accompanied by social–emotional problems. Recently, alexithymia has been suggested to explain objective emotion processing deficits in EDs. We tested if elevated levels of alexithymia may explain emotional face‐processing problems in a mixed ED group (N = 24, 19 with anorexia and five with bulimia), comparing them with high‐alexithymic (N = 25) and low‐alexithymic healthy controls (N = 25). Participants judged the mixture ratio of clear and ambiguous facial emotion blends while eye movements were recorded. The ED group was less accurate judging ambiguous blends containing anger or disgust and attended less to the faces compared with low‐alexithymic controls. Reduced attention to faces, in particular the eye region, was linked to confusion with ambiguous anger and disgust in the ED group only. Although significant group differences only emerged compared with low‐alexithymic controls, the visual attention patterns underlying the ED group's problems with subtle anger and disgust expressions were not driven by alexithymia. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Planimetric and volumetric changes of reef islands in response to wave conditions
Authors: Costa Mirella B. , Macedo Eduardo C. , Siegle Eduardo 
Published: August 2017

AbstractReef islands are morphologically dynamic features located on atolls and platform reefs that are very sensitive to wave‐induced processes on different timescales. The planform morphological evolution of reef islands is widely described; however, the mechanisms of the volumetric variations in response to wave energy are still poorly documented. To assess their multitemporal vertical and horizontal mobility, we performed a series of synchronous measurements of the volumetric changes and incident wave energies at two reef islands and a shingle bank at the Rocas Atoll in the South Atlantic Ocean. The results show the differences in the magnitudes and locations of the sediment mobility between the reef islands. Whereas one island remained stable on all timescales, with only small volumetric changes concentrated at its extremities, the other island (Farol Island) showed high mobility, especially during the energetic northern swell season. The gross volumetric change reached 10.03 × 103 m3 (5% of the total island volume) on a daily timescale; however, on a seasonal scale, the gross erosion was compensated by the gross accretion, indicating a cyclical seasonal pattern. Moreover, the observed volumetric changes induced by the waves on both daily and seasonal timescales did not result in large shoreline displacements. However, long‐term oceanward erosion and substantial lagoonward accretion were observed at Farol Island on a decadal scale, resulting in a pronounced change in its planform morphology. This appears to be promoted by at least three sediment transport pathways induced by waves at the atoll, including sediment adjustment between the reef islands. Our results show that reef islands on the same atoll can have very distinct morphological behaviors on daily, seasonal and decadal scales in response to the same boundary conditions. Copyright © 2017 John Wiley & Sons, Ltd.
Extended finite element modeling of production from a reservoir embedded with an arbitrary fracture network
Authors: Xia Yang , Jin Yan , Oswald Jay , Chen Mian , Chen Kangping 
Published: August 2017

SummaryA numerical scheme based on the eXtended Finite Element Method (XFEM) is proposed to simulate complex fluid flow in a fractured porous reservoir. By enriching the elements fully cut by the fracture and the near‐tip region, the flow mechanism including the tip flux singularity can be exactly represented in the XFEM formulation. Fluid transfer between the matrix and the fractures can be easily coupled, and XFEM also overcomes the sensitivity to the mesh used in the traditional unstructured discretizations, regardless of the complexity of the fracture network. The method is validated for a simple case by the exact analytical solution. Results are compared between XFEM and FEM. Case studies are presented to illustrate the power, efficiency, accuracy, and flexibility of the proposed method for simulating transient productive flow in reservoirs with complex fracture networks.
Measuring the market risk of freight rates: A forecast combination approach
Authors: Argyropoulos Christos , Panopoulou Ekaterini 
Published: August 2017

AbstractThis paper addresses the issue of freight rate risk measurement via value at risk (VaR) and forecast combination methodologies while focusing on detailed performance evaluation. We contribute to the literature in three ways: First, we reevaluate the performance of popular VaR estimation methods on freight rates amid the adverse economic consequences of the recent financial and sovereign debt crisis. Second, we provide a detailed and extensive backtesting and evaluation methodology. Last, we propose a forecast combination approach for estimating VaR. Our findings suggest that our combination methods produce more accurate estimates for all the sectors under scrutiny, while in some cases they may be viewed as conservative since they tend to overestimate nominal VaR.