bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population
Authors: Guauque-Olarte Sandra , Rivera-Herrera Ana-Lucia , Cifuentes-C Laura 
Published: November 2016

Background:CHEK2(Checkpoint Kinase 2) encodes CHK2, a serine/threonine kinase involved in maintaining the G1/S and G2/M checkpoints and repair of double-strand DNA breaks via homologous recombination. Functions of CHK2 include the prevention of damaged cells from going through the cell cycle or proliferating and the maintenance of chromosomal stability.CHEK2mutations have been reported in a variety of cancers including glioblastoma, ovarian, prostate, colorectal, gastric, thyroid, and lung cancer in studies performed mainly in White populations. The most studied mutation inCHEK2is c.1100delC, which was associated with increased risk of breast cancer. The objective of this study was to compile mutations inCHEK2identified in cancer genomics studies in different populations and especially in Latin American individuals.Methods:A revision of cancer genomics data repositories and a profound literature review of Latin American studies was performed.Results:Mutations with predicted high impact inCHEK2were reported in studies from Australia, Japan, United States, among other countries. The TCGA cancer types with most mutations inCHEK2were breast, colorectal, and non-small cell lung cancer. The most common mutation found was E321* in three patients with uterine cancer. In Latin American individuals nine mutations were found in melanoma, lymphoma, and head and neck cohorts from TCGA and ICGC. Latin American studies have been restricted to breast and colorectal cancer and only two mutations out of four that have been interrogated in this population were identified, namely c.1100delC and c.349A>G.Conclusions:This study presents a compilation of mutations inCHEK2with high impact in different cancer types in White, Hispanic and other populations. We also show the necessity of screeningCHEK2mutations in Latin American in cancer types different than breast and colorectal.
The Analysis of Socio-Cultural and Psychological Prerequisites of the Development of Extremism in the Crimean Federal District
Authors: Никитина  , Nikitina L. , Коноплева  , Konopleva A. , Чудина-Шмидт  , Chudina-Shmidt N. 
Published: November 2016

One of the most relevant topics for today´s research is the
problem of the rapid development of extremism. Because of the abstraction
and inaccuracies represented by the law, the fight against
extremist tendencies continues to be difficult. A kind of indicator for
the detection of possible threats from the point of view of radical
ideas is a transitional period. Changes in the geopolitical and socioeconomic
conditions. Lead to the an exacerbation of pre-existing
differences, and thus become catalysts of destructive processes. This
is precisely the situation that exists in the Crimean Federal District
today. The work is devoted to the study of social and psychological
preconditions for the emergence of extremism in the Crimean Federal
District. The data used in the research are obtained as a result of a poll
of the population of the region. The data of the survey has been assessed
in terms of psychological and social factors. The novelty of the research
lies in the implementation of a systematic approach to the problem of
the emergence of extremism and attempts to identify its regional
features.
Humanitarian Context of the 20s – 30s of the XX Century on the Example of the Work &#34;On the Meaning of Life&#34;. Part 2
Authors: Колесниченко  , Kolesnichenko Yu. 
Published: November 2016

The article presents an experience research of little-known
concept of the personality of the philosopher of the twentieth
century M.M. Rubinstein. An attempt was made to correlate the
meaning of his concept of the centers with the overall development
trend of domestic philosophical knowledge of 20s – 30s of the XX
century. Using the synchronic and diachronic approaches to the
study of the problem, the hermeneutic and analytical research
methods, the author defines terminology borders of ontognoseology,
socio-philosophical and psychological interpretations of the
concept of the person as a fundamental philosophical category.
The Bland truth: 1
Authors: Castledine George 
Published: November 2016

Care study Mr A played the piano in the local pub every Friday night. One day he got so drunk that on returning home to his small terraced house where he lived with his widowed mother, he fell out of bed and nearly choked on his vomit. His mother discovered him just in time and he was admitted to the local hospital. After several weeks of intensive care nursing and endless investigations and scans, he was declared by the medical staff to be unrehabilitative, and labelled vegetative and a long-term nursing problem. The ward nurses accepted the challenge and continued with appropriate nursing care, including tube feeding. Eventually, some 3 years later, the patient died. His mother was happy because she was not pressurized in any way to make a life or death decision about her son's condition. The nurses were happy because they felt they upheld their responsibility to do the patient no harm and aid him/her to a peaceful death. The doctors were at first unhappy because they were not able to use the patient's bed any sooner, but were satisfied that he was well cared for.
Penetration of n-Hexadecane and Water into Wood under Conditions Simulating Catastrophic Floods
Authors: Baglayeva Ganna , Seames Wayne S. , Frihart Charles R. , O'Dell Jane , Kozliak Evguenii I. 
Published: November 2016

Abstract
To simulate fuel oil spills occurring during catastrophic floods, short-term absorption of two chemicals, n-hexadecane (representative of semivolatile organic compounds in fuel oil) and water, into southern yellow pine was gravimetrically monitored as a function of time at ambient conditions. Different scenarios were run on the basis of (1) the order of contamination (n-hexadecane followed by water or vice versa) and (2) whether the wood lateral sides were covered with epoxy. The experiments were designed to evaluate fast initial sorption, allowing separate estimation of the end-grain (i.e., total longitudinal) and lateral (i.e., surface longitudinal) liquid penetration. Presaturation of wood with water did not significantly impede the subsequent penetration of n-hexadecane, whereas the presaturation of wood with n-hexadecane led to a significant decrease of the subsequent water uptake. This difference in penetration on the basis of the order of application was explained by the differences in the polarities of the two penetrating liquids and their impacts on the interactions with the wood matrix. Calculated apparent diffusivities for end-grain and lateral penetration were similar at ca. 3 × 10−7 m2/s, indicating that filling of easily accessible near-surface voids does not have a substantial impact on the overall penetration of contaminants into wood. The n-hexadecane distribution profiles based on penetration into wood blocks (obtained by means of gas chromatography) showed that water and n-hexadecane appear to use different (although overlapping) penetration paths owing to the differences in their physical properties.
Perceptions of mothers about food allergy - A preliminary report
Authors: Prawirohartono Endy P. 
Published: November 2016

The impact of food allergy on child growth and development should be properly evaluated, although the prevalence of food allergy is low. Most mothers in Indonesia still practice food elimination if their children are suspected to suffer from food allergy. Types of food that are usually avoided are high-class protein sources such as egg, milk, beef and fish. These types of foods are important for maintaining growth and development during childhood. The aim of this study is to know the perceptions of mothers about food allergy, including its pathophysiology, clinical symptoms and signs, management, and types of foods as allergens. Among mostly 114 of medium to highly educated mothers, there were still wrong perceptions about food allergy. From 114 mothers, 48.2% of them believed that food allergy can not be inherited, egg causes furuncle (54.3%), breast milk causes atopic eczema (46.5%), and food allergy does not relate to respiratory symptoms. There was a relationship between these perceptions and mothers’ educational level. Skin manifestations were most popular among mothers, whereas only 37.7% of mothers believed that food allergy can causes respiratory symptoms. Egg, shrimp, fish, and shellfish were types of animal foods which were popular, whereas peanut, soy, banana, rice and vegetables were recognized as the major causes of food allergy among non animal products.
Advanced control of direct-driven PMSG generator in wind turbine system
Authors: Gajewski Piotr , Pieńkowski Krzysztof 
Published: November 2016

Abstract
The paper presents the advanced control system of the wind energy conversion with a variable speed wind turbine. The considered system consists of a wind turbine with the permanent magnet synchronous generator (PMSG), machine side converter (MSC), grid side converter (GSC) and control circuits. The mathematical models of a wind turbine system, the PMSG generator and converters have been described. The control algorithms of the converter systems based on the methods of vector control have been applied. In the advanced control system of the machine side converter the optimal MPPT control method has been used. Additionally the pitch control scheme is included in order to achieve the limitation of maximum power and to prevent mechanical damage of the wind turbine. In the control system of the grid side converter the control of active and reactive power has been applied with the application of Voltage Oriented Control (VOC). The performance of the considered wind energy system has been studied by digital simulation. The results of simulation studies confirmed the good effectiveness of the considered wind turbine system and very good performance of the proposed methods of vector control and control systems.
Magnet loss analysis for a high-speed PM machine with segmented PM and modified tooth-tips shape
Authors: Mlot Adrian , Łukaniszyn Marian , Korkosz Mariusz 
Published: November 2016

Abstract
This paper presents the loss-oriented performance analysis of a radial highspeed permanent magnet (PM) machine with concentrated windings for automotive application. The PM synchronous machine was designed for an operating frequency up to 800 Hz. The main aim of this paper is to analyse the selected methods for magnet eddycurrent loss reduction. The first approach to rotor modification regards magnet segmentation in circumferential and axial directions. The second approach is based on changes in tooth-tips shape of the stator. The best variants of tooth-tip shapes are determined for further investigation, and adopted with a rotor having magnet segmentation. It is found that the machine with a segmented magnet leads to magnet loss reduction by 81%. Further loss reduction by 45% can be realized with the proposed tooth-tip shape. Additionally, owing to the stator and rotor modifications, the main machine parameters are investigated, such as back-EMF, electromagnetic torque, torque ripple and cogging torque. The 2-D and 3-D finite element analysis (FEA) is used for electromagnetic analysis. An experimental approach based on a partially wound stator is employed to verify the 3-D FEA.
Modeling of linear dispersive materials using scalable time domain finite element scheme
Authors: Butryło Bogusław 
Published: November 2016

Abstract
This paper deals with some aspects of formulation and implementation of a broadband algorithm with build-in analysis of some dispersive media. The construction of the finite element method (FEM) based on direct integration of Maxwell’s equations and solution of some additional convolution integrals is presented. The broadband, fractional model of permittivity is approximated by a set of some relaxation sub-models. The properties of the 3D time-dependent formulation of the FEM algorithm are determined using a benchmark problem with the Cole-Cole and the Davidson-Cole models. Several issues associated with the implementation and some constraints of the broadband finite element algorithm are presented.
Power supply risk assessment method for relay protection system faults
Authors: Tuyou Si , Jiekang Wu , Weideng Yuan , Anan Du 
Published: November 2016

Abstract
The influence and the potential risk due to hidden faults of a relay protection system on power supply in distribution systems are paid more and more attention to. A probability analysis method is used to analyse fault characteristics and action mechanism of dominant faults, hidden misoperation and non-operation of the relay protection systems, and failure probability model of relay protection system is constructed and simplified. The effects of dominant faults, hidden misoperation and non-operation of the relay protection systems on the reduced power supply load power are analysed, and a probabilistic model for reduced power supply load power is constructed by three parts corresponding to dominant faults, hidden misoperation and non-operation. A probability calculation method of power supply risk occurrence due to hidden faults of relay protecttion system is proposed considering the fault probability of the relay protection systems, the frequency of the hidden faults occurring in operation period, the reduced power supply load power or load power outage, and the connection mode of the in-lines, out-lines and transformers in a substation. The feasibility and applicability of the proposed method for estimation of risk value probability of the relay protection systems is verified by two studied examples.
A novel circuit topology of modified switched boost hybrid resonant inverter fitted induction heating equipment
Authors: Bhattacharya Ananyo , Sit Kaushik , Sadhu Pradip Kumar , Pal Nitai 
Published: November 2016

Abstract
A novel circuit topology of modified switched boost high frequency hybrid resonant inverter fitted induction heating equipment is presented in this paper for efficient induction heating. Recently, induction heating technique is becoming very popular for both domestic and industrial purposes because of its high energy efficiency and controllability. Generally in induction heating, a high frequency alternating magnetic field is required to induce the eddy currents in the work piece. High frequency resonant inverters are incorporated in induction heating equipment which produce a high frequency alternating magnetic field surrounding the coil. Previously this high frequency alternating magnetic field was produced by voltage source inverters. But VSIs have several demerits. So, in this paper, a new scheme of modified switched boost high frequency hybrid resonant inverter fitted induction heating equipment has been depicted which enhances the energy efficiency and controllability and the same is validated by PSIM.
Effect of drying methods for inner parameters of red beetroot (Beta vulgaris L.)
Authors: Székely D. , Illés B. , Stéger-Máté M. , Monspart-Sényi J. 
Published: November 2016

AbstractIn compliance with consumer expectations, careful processing and preservation are increasingly used with fruits and vegetables. The aim is that during these treatments the valuable nutritional characteristics of the raw materials change as little as possible. Drying has been used for the preservation of raw materials for a long time, which can distinguish two different groups based upon pressure. These are the atmospheric and the more careful vacuum drying.During the research, Alto F1 beetroots were being dried in vacuum and under atmospheric pressure at different temperatures. Vacuum drying took place at 40, 50, and 60 °C, while atmospheric drying at 60, 70, and 80 °C. All drying processes lasted 150 minutes. During drying, changes of moisture content and water activity were monitored. After drying, colour measurement was realized and the inner parameters were investigated, such as polyphenol, betalain, and antioxidant capacity. These measured parameters were compared in the ease of atmospheric and vacuum drying.
Computation of spatio-temporal parameters in level walking using a single inertial system in lean and obese adolescents
Authors: Cimolin Veronica , Capodaglio Paolo , Cau Nicola , Galli Manuela , Santovito Cristina , Patrizi Alessandra , Tringali Gabriella , Sartorio Alessandro 
Published: November 2016

AbstractIn recent years, the availability of low-cost equipment capable of recording kinematic data during walking has facilitated the outdoor assessment of gait parameters, thus overcoming the limitations of three-dimensional instrumented gait analysis (3D-GA). The aim of this study is twofold: firstly, to investigate whether a single sensor on the lower trunk could provide valid spatio-temporal parameters in level walking in normal-weight and obese adolescents compared to instrumented gait analysis (GA); secondly, to investigate whether the inertial sensor is capable of capturing the spatio-temporal features of obese adolescent gait. These were assessed in 10 obese and 8 non-obese adolescents using both a single inertial sensor on the lower trunk and an optoelectronic system. The parameters obtained were not statistically different in either normal-weight or obese participants between the two methods. Obese adolescents walked with longer stance and double support phase compared to normal-weight participants. The results showed that the inertial system is a valid means of evaluating spatio-temporal parameters in obese individuals.
Multicenter performance evaluation of a second generation cortisol assay
Authors: Vogeser Michael , Kratzsch Jürgen , Ju Bae Yoon , Bruegel Mathias , Ceglarek Uta , Fiers Tom , Gaudl Alexander , Kurka Hedwig , Milczynski Christoph , Prat Knoll Cristina , Suhr Anna C. , Teupser Daniel , Zahn Ingrid , Ostlund Richard E. 
Published: November 2016

Abstract

Background:
Untreated disorders of the adrenocortical system, such as Cushing’s or Addison’s disease, can be fatal, and accurate quantification of a patient’s cortisol levels is vital for diagnosis. The objective of this study was to assess the analytical performance of a new fully-automated Elecsys® Cortisol II assay (second generation) to measure cortisol levels in serum and saliva.

Methods:
Four European investigational sites assessed the intermediate precision and reproducibility of the Cortisol II assay (Roche Diagnostics) under routine conditions. Method comparisons of the Cortisol II assay vs. liquid chromatography-tandem mass spectrometry (LC-MS/MS), the gold standard for cortisol measurement, were performed. Cortisol reference ranges from three US sites were determined using samples from self-reported healthy individuals.

Results:
The coefficients of variation (CVs) for repeatability, intermediate precision, and reproducibility for serum samples were ≤2.6%, ≤5.8%, and ≤9.5%, respectively, and for saliva were ≤4.4% and ≤10.9%, and ≤11.4%, respectively. Agreement between the Cortisol II assay and LC-MS/MS in serum samples was close, with a slope of 1.02 and an intercept of 4.473 nmol/L. Reference range samples were collected from healthy individuals (n=300) and serum morning cortisol concentrations (5–95th percentile) were 166.1–507 nmol/L and afternoon concentrations were 73.8–291 nmol/L. Morning, afternoon, and midnight saliva concentrations (95th percentile) were 20.3, 6.94, and 7.56 nmol/L, respectively.

Conclusions:
The Cortisol II assay had good precision over the entire measuring range and had excellent agreement with LC-MS/MS. This test was found suitable for routine diagnostic application and will be valuable for the diagnosis of adrenocortical diseases.
Discourses on Witchcraft and Uses of Witchcraft Discourse
Authors: Mencej Mirjam 
Published: November 2016

Abstract:Based on field research, this article discusses various discourses that the inhabitants of the Eastern Slovenian region could use when discussing witchcraft. Further on it focuses on various possible uses of the witchcraft discourse: as long as witchcraft discourse had enough open support in the region, it constituted the context in which witchcraft narratives were “shared with licence”, which enabled people to draw upon and mobilize them for various purposes and with various intentions. This paper gives examples of how bewitchment narratives served as a strategy that individuals could appropriate and use to their benefit in everyday life.
Incentive and Architecture of Multi-Band Enabled Small Cell and UE for Up-/Down-Link and Control-/User-Plane Splitting for 5G Mobile Networks
Authors: Saha Rony Kumer , Aswakul Chaodit 
Published: November 2016

Abstract
In this paper, a multi-band enabled femtocell base station (FCBS) and user equipment (UE) architecture is proposed in a multi-tier network that consists of small cells, including femtocells and picocells deployed over the coverage of a macrocell for splitting uplink and downlink (UL/DL) as well as control-plane and user-plane (C-/U-plane) for 5G mobile networks. Since splitting is performed at the same FCBS, we define this architecture as the same base station based split architecture (SBSA). For multiple bands, we consider co-channel (CC) microwave and different frequency (DF) 60 GHz millimeter wave (mmWave) bands for FCBSs and UEs with respect to the microwave band used by their over-laid macrocell base station. All femtocells are assumed to be deployed in a 3-dimensional multi-storage building. For CC microwave band, cross-tier CC interference of femtocells with macrocell is avoided using almost blank subframe based enhanced inter-cell interference coordination techniques. The co-existence of CC microwave and DF mmWave bands for SBSA on the same FCBS and UE is first studied to show their performance disparities in terms of system capacity and spectral efficiency in order to provide incentives for employing multiple bands at the same FCBS and UE and identify a suitable band for routing decoupled UL/DL or C-/U-plane traffic. We then present a number of disruptive architectural design alternatives of multi-band enabled SBSA for 5G mobile networks for UL/DL and C-/U-plane splitting, including a disruptive and complete splitting of UL/DL and C-/U-plane as well as a combined UL/DL and C-/U-plane splitting, by exploiting dual connectivity on CC microwave and DF mmWave bands. The outperformances of SBSA in terms of system level capacity, average spectral efficiency, energy efficiency, and control-plane overhead traffic capacity in comparison with different base stations based split architecture (DBSA) are shown. Finally, a number of technical and business perspectives as well as key research issues of SBSA are discussed.
Solving a Linear Optimization Word Problems by Using GeoGebra
Authors: Molnár Pavel 
Published: November 2016

Abstract
Today's modern age is characterized by the rapid development of information and communication technologies, which is also reflected in the educational process. It is therefore necessary to prepare the young generation of even at primary and secondary schools to solve problems from real life. Using the appropriate motivation, innovative methods and application of modern information and communication technologies into the teaching process, we can succeed. Constructions created using by dynamic geometry systems bring new opportunities to learning. The aim of this article is to introduce the possibility of using GeoGebra in graphics solution of system of linear inequalities and also in the geometric interpretation of solutions to word problems leading to the linear optimization. The article describes the observations of experimental teaching, where was used GeoGebra. The experimental teaching was conducted at a grammar school in Košice. GeoGebra offers suitable tools to create graphical models in solving the optimization problems.