bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactivity‐Tuning in Frustrated Lewis Pairs: Nucleophilicity and Lewis Basicity of Sterically Hindered Phosphines
Authors: Follet Elsa , Mayer Peter , Stephenson David S. , Ofial Armin R. , Berionni Guillaume 
Published: March 2017

AbstractThe nucleophilicity and Lewis basicity of sterically hindered phosphines, widely used in catalysis and in frustrated Lewis pair (FLP) chemistry, have been quantified by determining the rates and equilibrium constants of their associations with reference systems (benzhydrylium and tritylium ions) of calibrated electrophilicities and Lewis acidities. These structure–reactivity investigations allow a rationalization of the Lewis acid–base interactions all along the way from covalent Lewis adducts to FLPs. Comparisons of the association of phosphines of increasing sizes (Ph3P, (o‐tolyl)3P, and tBu3P) with the triarylborane B(C6F5)3 and with the isoelectronic tritylium ions Ar3C+ provide detailed insights for the future fine‐tuning of the reactivities of FLPs. As a proof of concept, tritylium‐ion‐derived FLPs were shown to react with alkynes, as reported for the FLPs derived from the benchmark triarylborane B(C6F5)3.
Perceptual and emotional effects of light and color in a simulated retail space
Authors: Lombana Maria , Tonello Graciela Lucia 
Published: March 2017

AbstractThis article aims to address two aspects of lighting often treated intuitively by designers in charge of creating retail atmospheres, that is, the impact of color and light distribution, as design variables. The study comprised a controlled experiment with a repeated measure design with three directions of lighting (front, overhead, and wallwasher), as the within‐subject factor and four color combinations of the walls (yellow‐blue, magenta, gray, and green‐magenta), as the between‐group variable. The perceptual (visually) and emotional responses of 184 participants revealed the interplay between light and color on these psychological outcomes. Specifically, the results showed that the overhead direction of lighting improves the appearance of the less favored color conditions, either in terms of lack of visual complexity (monochromatic) or color itself (gray). In turn, the wallwasher lighting emphasized these attributes, differing according to visual or emotional aspects. In retailing, emotional dimensions such as activation and evaluation are desired, and they were confirmed across all the lighting and color conditions of this study. The results provide designers with certain perceptual cues regarding colors and their lighting mode to create desirable impressions and affect in retail spaces.
Pre‐exposure to cocaine or morphine attenuates taste avoidance conditioning in adolescent rats: Drug specificity in the US pre‐exposure effect
Authors: Clasen Matthew M. , Hempel Briana J. , Riley Anthony L. 
Published: March 2017

AbstractAlthough the attenuating effects of drug history on conditioned taste avoidance (CTA) learning have been widely investigated in adults, such effects in adolescents have not been well characterized. Recent research has suggested that the display of the drug pre‐exposure effect during adolescence may be drug dependent given that pre‐exposure to ethanol attenuates subsequent conditioning, whereas pre‐exposure to the classic emetic lithium chloride (LiCl) fails to do so. The present study began investigating the possible drug‐dependent nature of the effects of drug pre‐exposure by pre‐exposing and conditioning adolescent male Sprague–Dawley rats to drugs from two additional classes, specifically psychostimulants (cocaine; Experiment 1) and opioids (morphine; Experiment 2). Consistent with prior work with ethanol (but not LiCl), prior exposure to both cocaine and morphine attenuated taste avoidance induced by these compounds. Although this work supports the view of drug‐dependent pre‐exposure effects on taste avoidance learning during adolescence, research is needed to assess its mechanisms.
High‐dose or low‐dose cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer
Authors: Chang Chia‐Lun , Yuan Kevin Sheng‐Po , Wu Szu‐Yuan 
Published: March 2017

AbstractBackgroundNo randomized studies have compared low‐dose or high‐dose concurrent chemoradiotherapy (CRT).MethodsIn this study, 7219 patients with stage III or IV head and neck squamous cell carcinoma (HNSCC) were enrolled and categorized into 2 groups: group 1, comprising those undergoing low‐dose concurrent CRT (n = 1575), and group 2, comprising those receiving high‐dose concurrent CRT (n = 5644).ResultsCox regression analyses revealed that age ≥65 years, male, high Charlson comorbidity index (CCI) scores, radiotherapy (RT) duration ≥7.5 weeks, clinical stage IV cancer, oral cavity cancers, tobacco smoking, and total cisplatin dose ≥240 mg/m2 were significant independent prognostic risk factors for overall survival (OS). After adjustment for confounders, the adjusted hazard ratio (aHR; 95% confidence interval [CI]) for overall mortality was 0.83 (0.78‐0.89; P < .001) in patients with oral cavity HNSCC undergoing high‐dose concurrent CRT and 0.82 (0.77‐0.94; P < .001) in patients with nonoral cavity HNSCC receiving high‐dose concurrent CRT.ConclusionHigh‐dose concurrent CRT can reduce the incidence of death in patients with stage III or IV HNSCC.
p16INK4a: A surrogate marker of high‐risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule
Authors: Vital Domenic , Holzmann David , Huber Gerhard F. , Soyka Michael B. , Moch Holger , Zimmermann Dieter R. , Ikenberg Kristian 
Published: March 2017

AbstractBackgroundThe purpose of this study was to analyze the role of p16INK4a and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule.MethodsPatients diagnosed from 1995 to 2014 were included in this study. Assessment of p16INK4a and HPV‐DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16INK4a positivity was defined as unequivocal nuclear and cytoplasmic staining of ≥70% of the cells, whereas 50%‐69% was considered to be a “borderline” result.ResultsThere were 46 patients with SCCs of the nasal vestibule, of whom 31 (67.4%) were available for p16INK4a and 30 (65.2%) for analysis of HPV. Expression of p16INK4a was present in 19.4% and showed coincidence with high‐risk HPV (P < .001). Neither p16INK4a nor HPV‐DNA had significant impact on outcome.ConclusionSignificant immunoreactivity for p16INK4a was present in about one‐fifth of the samples and figured as a surrogate marker of high‐risk HPV infection. There was no influence on outcome.
Hearing loss and speech perception in noise difficulties in Fanconi anemia
Authors: Verheij Emmy , Oomen Karin P. Q. , Smetsers Stephanie E. , van Zanten Gijsbert A. , Speleman Lucienne 
Published: March 2017

Objectives/HypothesisFanconi anemia is a hereditary chromosomal instability disorder. Hearing loss and ear abnormalities are among the many manifestations reported in this disorder. In addition, Fanconi anemia patients often complain about hearing difficulties in situations with background noise (speech perception in noise difficulties). Our study aimed to describe the prevalence of hearing loss and speech perception in noise difficulties in Dutch Fanconi anemia patients.Study DesignRetrospective chart review.MethodsA retrospective chart review was conducted at a Dutch tertiary care center. All patients with Fanconi anemia at clinical follow‐up in our hospital were included. Medical files were reviewed to collect data on hearing loss and speech perception in noise difficulties.ResultsIn total, 49 Fanconi anemia patients were included. Audiograms were available in 29 patients and showed hearing loss in 16 patients (55%). Conductive hearing loss was present in 24.1%, sensorineural in 20.7%, and mixed in 10.3%. A speech in noise test was performed in 17 patients; speech perception in noise was subnormal in nine patients (52.9%) and abnormal in two patients (11.7%).ConclusionsHearing loss and speech perception in noise abnormalities are common in Fanconi anemia. Therefore, pure tone audiograms and speech in noise tests should be performed, preferably already at a young age, because hearing aids or assistive listening devices could be very valuable in developing language and communication skills.Level of Evidence4. Laryngoscope, 127:2358–2361, 2017
Periodic olfactory assessment in patients undergoing skull base surgery with preservation of the olfactory strip
Authors: Upadhyay Smita , Buohliqah Lamia , Dolci Ricardo L. L. , Otto Bradley A. , Prevedello Daniel M. , Carrau Ricardo L. 
Published: March 2017

Objectives/HypothesisOthers have reported olfactory disturbances following endoscopic approaches to the skull base. However, there is a lack of consensus on the extent and duration of dysfunction. This study aimed to compare our results with previously published work and to validate the olfactory strip–sparing approach.Study DesignProspective study to assess olfaction in 50 patients scheduled to undergo resection of skull base tumors via extended endoscopic approaches.MethodsPatients were divided into two groups. Group I had a nasoseptal flap (NSF), and group II included patients in whom rescue flaps were performed bilaterally. Olfactory outcomes were assessed using repeated University of Pennsylvania Smell Identification Test at baseline, 6 weeks, 3 months, and 6 months following surgery.ResultsUltimately, 42 patients (seven group I and 35 group II) were available for assessment. Scores for group I were lower than at baseline at 6 weeks postoperatively (30.71 ± 5.5 vs. 24.5 ± 5.4; P = .05). However, by the third postoperative month the scores had improved to a level that was not significantly different from baseline (29.0 ± 3.7; P = .5). At 6 months, the score was 30.0 ± 3.9. Patients in group II showed no difference between their baseline and 6‐week scores (31.5 ± 5.3 vs. 29.7 ± 5.9; P = .16). Six months postoperatively, the score was significantly higher (33.78 ± 3.6; P = .04).ConclusionsExpanded endoscopic approaches to skull base tumors involving reconstruction with an NSF are associated with a short‐term negative impact on olfaction. Olfaction does not seem to be affected by the surgical resection of pituitary adenomas associated with rescue flaps. Identification of the olfactory epithelium and meticulous harvesting of the NSF are critical to preserve olfaction.Level of Evidence4. Laryngoscope, 127:1970–1975, 2017
Nerve transection repair using laser‐activated chitosan in a rat model
Authors: Bhatt Neel K. , Khan Taleef R. , Mejias Christopher , Paniello Randal C. 
Published: March 2017

Objectives/HypothesisCranial nerve transection during head and neck surgery is conventionally repaired with microsuture. Previous studies have demonstrated recovery with laser nerve welding (LNW), a novel alternative to microsuture. LNW has been reported to have poorer tensile strength, however. Laser‐activated chitosan, an adhesive biopolymer, may promote nerve recovery while enhancing the tensile strength of the repair. Using a rat posterior tibial nerve injury model, we compared four different methods of nerve repair in this pilot study.Study DesignAnimal study.DesignAnimals underwent unilateral posterior tibial nerve transection. The injury was repaired by potassium titanyl phosphate (KTP) laser alone (n = 20), KTP + chitosan (n = 12), microsuture + chitosan (n = 12), and chitosan alone (n = 14). Weekly walking tracks were conducted to measure functional recovery (FR). Tensile strength (TS) was measured at 6 weeks.ResultsAt 6 weeks, KTP laser alone had the best recovery (FR = 93.4% ± 8.3%). Microsuture + chitosan, KTP + chitosan, and chitosan alone all showed good FR (87.4% ± 13.5%, 84.6% ± 13.0%, and 84.1% ± 10.0%, respectively). One‐way analysis of variance was performed (F(3,56) = 2.6, P = .061). A TS threshold of 3.8 N was selected as a control mean recovery. Three groups—KTP alone, KTP + chitosan, and microsuture + chitosan—were found to meet threshold 60% (95% confidence interval [CI]: 23.1%‐88.3%), 75% (95% CI: 46.8%‐91.1%), and 100% (95% CI: 75.8%‐100.0%), respectively.ConclusionsIn the posterior tibial nerve model, all repair methods promoted nerve recovery. Laser‐activated chitosan as a biopolymer anchor provided good TS and appears to be a novel alternative to microsuture. This repair method may have surgical utility following cranial nerve injury during head and neck surgery.Level of EvidenceNA Laryngoscope, 127:E253–E257, 2017
Changes to cholesterol trafficking in macrophages by Leishmania parasites infection
Authors: Semini Geo , Paape Daniel , Paterou Athina , Schroeder Juliane , Barrios‐Llerena Martin , Aebischer Toni 
Published: March 2017

AbstractLeishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases. It has been demonstrated that host cholesterol plays an important role during Leishmania infection. Nevertheless, little is known about the intracellular distribution of this lipid early after internalization of the parasite. Here, pulse‐chase experiments with radiolabeled cholesteryl esterified to fatty acids bound to low‐density lipoproteins indicated that retention of this source of cholesterol is increased in parasite‐containing subcellular fractions, while uptake is unaffected. This is correlated with a reduction or absence of detectable NPC1 (Niemann–Pick disease, type C1), a protein responsible for cholesterol efflux from endocytic compartments, in the Leishmania mexicana habitat and infected cells. Filipin staining revealed a halo around parasites within parasitophorous vacuoles (PV) likely representing free cholesterol accumulation. Labeling of host cell membranous cholesterol by fluorescent cholesterol species before infection revealed that this pool is also trafficked to the PV but becomes incorporated into the parasites’ membranes and seems not to contribute to the halo detected by filipin. This cholesterol sequestration happened early after infection and was functionally significant as it correlated with the upregulation of mRNA‐encoding proteins required for cholesterol biosynthesis. Thus, sequestration of cholesterol by Leishmania amastigotes early after infection provides a basis to understand perturbation of cholesterol‐dependent processes in macrophages that were shown previously by others to be necessary for their proper function in innate and adaptive immune responses.
Inter‐ONU‐communication over different wavelength group in next generation pon based on physical‐layer network coding
Authors: Lu Yang , Bi Meihua , Qian Zhengfeng , Hu Miao , Wei Yizhen , Yang Guowei , Li Qiliang 
Published: March 2017

ABSTRACTAn inter‐ONU‐communication (IOC) between different wavelength groups is proposed for next generation PON. The proposed IOC is based on physical‐layer network coding (PNC) to provide full‐duplex and private communications. The IOC requires no extra transmitter or receiver. 10‐Gb/s error‐free communications are experimentally demonstrated. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1068–1071, 2017
Bandwidth enhancement of microstrip antenna loaded by parasitic zeroth‐order resonators
Authors: Peng Lin , Mao Jing‐Yao , Li Xiao‐Feng , Jiang Xing , Ruan Cheng‐Li 
Published: March 2017

ABSTRACTNew zeroth‐order resonators (ZORs) were utilized as parasitic elements to enhance bandwidth of microstrip antenna. By utilizing one, two and three resonators, extra corresponding numbers of resonances were generated. Then, by merging the resonances of the resonators with that of the microstrip antenna, the measured impedance bandwidth can be increased from 56 MHz of the reference microstrip antenna to 101, 120, and 133 MHz of the ZORs loaded antennas. As the ZOR is very small (approximately λ0/10), the antenna area ratio of the proposed bandwidth enhanced antennas to the referenced microstrip antenna (RMA) is only approximately 1.33. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1096–1100, 2017
A broadband miniaturized UHF RFID dipole tag antenna with tapered meandered arms
Authors: Mathew Jibish , Abraham Manju , Aanandan C.K. , Mathew Thomaskutty 
Published: March 2017

ABSTRACTA novel miniaturized UHF RFID tag antenna (26.4 × 24 × 1.6 mm3) for broadband operation over the UHF RFID band with good read range characteristics are proposed. The tag consists of a T‐matched dipole antenna with tapered meandered arms whose ends are folded to one side and an RFID chip is connected to the terminals of the antenna. The resonant frequency can be tuned by varying the gap width between the folded arms so that maximum read range can be achieved in the required territory's allotted band, without affecting its overall size. The measured read range variations with angular ranges for the proposed tag designed for maximum read range at 915 MHz are also presented. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1142–1145, 2017
Stress, cortisol, and other appetite‐related hormones: Prospective prediction of 6‐month changes in food cravings and weight
Authors: Chao Ariana M. , Jastreboff Ania M. , White Marney A. , Grilo Carlos M. , Sinha Rajita 
Published: March 2017

ObjectiveTo examine whether baseline chronic stress, morning cortisol, and other appetite‐related hormones (leptin, ghrelin, and insulin) predict future weight gain and food cravings in a naturalistic, longitudinal, 6‐month follow‐up study.MethodsA prospective community cohort of 339 adults (age 29.1 ± 9.0 years; BMI = 26.7 ± 5.4 kg/m2; 56.9% female; 70.2% white) completed assessments at baseline and 6‐month follow‐up. Fasting blood draws were used to assess cortisol and other appetite‐related hormone levels at baseline. At baseline and follow‐up, body weight was measured, and the Cumulative Adversity Interview and Food Craving Inventory were administered. Data were analyzed using linear mixed models adjusting for demographic and clinical covariates.ResultsOver the 6‐month period, 49.9% of the sample gained weight. Food cravings and chronic stress decreased over 6 months (Ps < 0.05). However, after adjusting for covariates, individuals with higher baseline total ghrelin had significantly higher food cravings at 6 months (P = 0.04). Furthermore, higher cortisol, insulin, and chronic stress were each predictive of greater future weight gain (Ps < 0.05).ConclusionsThese results suggest that ghrelin plays a role in increased food cravings and reward‐driven eating behaviors. Studies are needed that examine the utility of stress reduction methods for normalizing disrupted cortisol responses and preventing future weight gain.
An adaptive chaos particle swarm optimization for tuning parameters of PID controller
Authors: Nie Shan‐Kun , Wang Yu‐Jia , Xiao Shanli , Liu Zhifeng 
Published: March 2017

SummaryAn adaptive chaos particle swarm optimization (ACPSO) is presented in this paper to tune the parameters of proportional‐integral‐derivative (PID) controller. To avoid the local minima, we introduced a constriction factor. Meanwhile, the chaotic searching is combined with the particle swarm optimization to improve the ability of the proposed algorithm. A series of experiment is performed on 6 benchmark functions to confirm its performance. It is found that the ACPSO can get better solution quality in solving the global optimization problems and avoiding the premature convergence. Based on it, the proposed algorithm is applied to tune the PID controller's parameters. The performances of the ACPSO are compared with different inspired algorithms, and these results show that the ACPSO is more robust and efficient when it is used to find the optimal parameters of PID controller.
Activation mechanisms of the first sphingosine‐1‐phosphate receptor
Authors: Caliman Alisha D. , Miao Yinglong , McCammon J. Andrew 
Published: March 2017

AbstractActivation of the first sphingosine‐1‐phosphate receptor (S1PR1) promotes permeability of the blood brain barrier, astrocyte and neuronal protection, and lymphocyte egress from secondary lymphoid tissues. Although an agonist often activates the S1PR1, the receptor exhibits high levels of basal activity. In this study, we performed long‐timescale molecular dynamics and accelerated molecular dynamics (aMD) simulations to investigate activation mechanisms of the ligand‐free (apo) S1PR1. In the aMD enhanced sampling simulations, we observed four independent events of activation, which is characterized by close interaction between Y3117.53 and Y2215.58 and increased distance between the intracellular ends of transmembrane (TM) helices 3 and 6. Although TM helices TM3, TM6, TM5 and, TM7 are associated with GPCR activation, we discovered that their movements are not necessarily correlated during activation. Instead, TM5 showed a decreased correlation with each of these regions during activation. During activation of the apo receptor, Y2215.58 and Y3117.53 became more solvated, because a water channel formed in the intracellular pocket. Additionally, a lipid molecule repeatedly entered the receptor between the extracellular ends of TM1 and TM7, providing important insights into the pathway of ligand entry into the S1PR1.
A Comparative Study of Electrochemical, Spectroscopic and Structural Properties of Phenyl, Thienyl and Furyl Substituted Ethylenes
Authors: Viglianti Lucia , Villafiorita‐Monteleone Francesca , Botta Chiara , Mussini Patrizia R. , Ortoleva Emanuele , Cauteruccio Silvia , Licandro Emanuela , Baldoli Clara 
Published: March 2017

Abstracta detailed electrochemical and photophysical comparative study of three parallel series of phenyl, thienyl and furyl substituted ethylenes has been carried out, implemented by the computational calculation of selected terms. Relationships have been highlighted between molecular structure (number and type of aromatic rings) and important functional properties (in particular, electronic features and oligomerization ability). Interestingly, some of the studied heteroaryl‐ethylenes show emission in the solid state displaying an aggregation‐induced emission behavior.
Ligand‐Free Copper‐Catalyzed Cyano‐ and Alkynylstannylation of Arynes
Authors: Yoshida Hiroto , Kubo Teruhiko , Kuriki Hitoshi , Osaka Itaru , Takaki Ken , Ooyama Yousuke 
Published: March 2017

AbstractA carbon–carbon triple bond of arynes was found to undergo cyanostannylation with a tin cyanide under CuCN catalysis to afford diverse ortho‐cyanoarylstannanes in high yield. The copper catalyst was also effective for alkynylstannylation of arynes, and the resulting alkynylstannylated products were demonstrated to be convertible into biologically active compounds and a dye for dye‐sensitized solar cell.
The Use of AOBH‐DEHP Molecular Probe to Characterize BHDC Reverse Micelles Interfaces. Insights on the Interfacial Water Structure
Authors: Crosio Matías A. , Silber Juana J. , Moyano Fernando , Correa N. Mariano , Falcone R. Darío 
Published: March 2017

AbstractThis work presents the use of the molecular probe: 3,6‐bis(dimethylamino) acridinium bis‐(2‐ethylhexyl) phosphate salt, AOBH‐DEHP. This probe is used to gain insights into the properties of the benzene/benzyl‐n‐hexadecyldimethylammonium chloride (BHDC)/water reverse micelles (RMs) interfaces. The techniques employed were absorption and emission spectroscopy in addition to the steady‐state and, time‐resolved fluorescence emission.For BHDC RMs without water addition, AOBH‐DEHP can be used to determine the critical micellar concentration, CMC. Upon addition of water, we detect, at concentrations of BHDC lower < 1x10−2 M, a proton transfer process from the AOBH+ cation to the DEHP− anion producing AOB species. However, for [BHDC] > 10−2 M, when the RMs is completely formed this process is reverted because water molecules at the interface interact with the cationic polar head of BHDC through the oxygen non‐bonding electron pair enhancing their hydrogen bond ability and acidity, hence it can easily transfer a proton to AOB species to form AOBH+.