bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA30: Technologies for personalizing cancer immunotherapies
Authors: Heath James R. , Peng Songming , Hsu Alice , Esswein Shannon , Heath John , Noh Won Jun , Zaretsky Jesse , Ribas Toni 
Published: November 2016

Abstract
At the heart of most cancer immunotherapies are the specific interactions between the principal cancer cell killers, T cells, and antigens presented by the tumor cells. Those interactions may be exposed through the use of checkpoint inhibitors, or they can be amplified through the use of engineered cell-based therapies. A class of antigens that has emerged as being particularly important are neoantigens, which are small fragments of mutated proteins that contain the mutation, and, for CD8+ T cell recognition, are presented by MHC Class I. In principle, neoantigens that draw T cells into a tumor can comprise personalized vaccines, and the T cell receptors (TCRs) that recognize those neoantigens can be engineered as personalized cellular therapies. However, identifying which neoantigens are drawing which T cells into the tumor and promoting cell killing has been a challenge. In this talk I will describe an approach, called nanoparticle-barcoded nucleic acid cell sorting (NP-barcoded NACS), designed for this purpose. The approach begins with a list of putative neoantigens generated from in silico analysis of the tumor genome and transcriptome. Those neoantigens are prepared as a NP-barcoded NACS library so that each neoantigen is paired with a DNA barcode. The entire library is then used to precipitate neoantigen specific CD8+ T cell populations from the patient's tumor or blood. Each cell is then individually decoded using sequential fluorescent reads to identify its cognate antigen, and the T cells may be further separated for single cell TCR sequencing. We have used this method to analyze tumor materials and blood from melanoma cancer patients responding to anti-PD-1 therapy, mouse models of immunotherapy, and tumor materials collected from various other cancer patients. The method, which is shown to be at least an order of magnitude more sensitive than alternative approaches, requires very little material, and so may be used for the analysis of non-expanded tumor infiltrating lymphocytes (TILs) or peripheral blood mononuclear cells (PBMCs). I will discuss some of the analytical details of this method, and prospects for harnessing it to develop personalized immunotherapies. I will also provide results of kinetic studies, via blood analysis, that appear to provide insights into patient responses to checkpoint inhibitor therapy.
Citation Format: James R. Heath, Songming Peng, Alice Hsu, Shannon Esswein, John Heath, Won Jun Noh, Jesse Zaretsky, Toni Ribas. Technologies for personalizing cancer immunotherapies [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr IA30.
Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence
Authors: Timpka Simon , Macdonald‐Wallis Corrie , Hughes Alun D. , Chaturvedi Nishi , Franks Paul W. , Lawlor Debbie A. , Fraser Abigail 
Published: November 2016

Background
Fetal exposure to preeclampsia is associated with higher blood pressure and later risk of stroke. We aimed to investigate the associations of maternal preeclampsia, gestational hypertension, and maternal blood pressure change in pregnancy with offspring cardiac structure and function in adolescence.

Methods and Results

Using data from a prospective birth cohort study, we included offspring who underwent echocardiography (mean age, 17.7 years;
SD
, 0.3; N=1592). We examined whether hypertensive disorders of pregnancy were associated with offspring cardiac structure and systolic/diastolic function using linear regression. Using multilevel linear spline models (measurement occasions within women), we also investigated whether rate of maternal systolic/diastolic blood pressure change during pregnancy (weeks 8–18, 18–30, 30–36, and 36 or more) were associated with offspring outcomes. Main models were typically adjusted for maternal age, offspring age and sex, prepregnancy body mass index, parity, glycosuria/diabetes mellitus, education, and maternal smoking. Exposure to maternal preeclampsia (0.025; 95% CI, 0.008–0.043) and gestational hypertension (0.010; 0.002–0.017) were associated with greater relative wall thickness. Furthermore, preeclampsia was also associated with a smaller left ventricular end‐diastolic volume (−9.0 mL; −15 to −3.1). No associations were found between hypertensive disorders of pregnancy and offspring cardiac function. Positive rate of maternal systolic blood pressure change during weeks 8 to 18 was associated with greater offspring left ventricular end‐diastolic volume, left ventricular mass indexed to height
2.7
, and E/A.

Conclusions
Adolescent offspring exposed to maternal preeclampsia had greater relative wall thickness and reduced left ventricular end‐diastolic volume, which could be early signs of concentric remodeling and affect future cardiac function as well as risk of cardiovascular disease.
Electrophysiology Study for Complex Supraventricular Tachycardia in Congenital Heart Disease Patients With Single‐Ventricle Physiology
Authors: Chiu Shuenn‐Nan , Wang Jou‐Kou , Lu Chun‐Wei , Wu Kun‐Lang , Tseng Wei‐Chieh , Wu Mei‐Hwan 
Published: November 2016

Background
Supraventricular tachycardia (SVT) is common in complex congenital heart disease (CCHD) patients with single‐ventricle physiology and may cause hemodynamic deterioration. We reported the outcomes of catheter ablation for such complex SVT in these single‐ventricle CCHD patients.

Methods and Results
Patients with single‐ventricle physiology (defined as CCHD patients) who received electrophysiology studies and catheter ablation between 1995 and 2015 were studied. We enrolled 30 CCHD patients (18 with right atrial isomerism, 5 with left atrial isomerism, and 7 with other CCHDs; 17 male, 13 female). The age of onset of clinical SVT was 6.7 years (±4.7 years). Electrophysiology studies and ablation were performed at age 7.1 years (±3.9 years); body weight was 20.7 kg (±10.0 kg). Twin atrioventricular nodes were present in 60% of patients (right atrial isomerism, 72.2%; left atrial isomerism, 40%; other CCHDs, 42.9%). Manifested preexcitation was noted in 10% of patients. SVT was induced in 21 patients. Twin atrioventricular nodal reentrant tachycardia was the most common (57.1%), followed by atrioventricular reentrant tachycardia (28.6%), junctional tachycardia (14.3%), and atrioventricular nodal reentrant tachycardia (9.5%). Multiple arrhythmias were common (33.3%), particularly in patients with atrioventricular reentrant tachycardia (50%). Ablation successfully eliminated SVT in 12 of 14 patients (85.7%), with a recurrence rate of 16.7% during 6 years of follow‐up.

Conclusions
Transcatheter ablation of complex SVT substrates, including minor atrioventricular node of twin atrioventricular nodal reentrant tachycardia, accessory pathways of atrioventricular reentrant tachycardia, and a slow pathway of atrioventricular nodal reentrant tachycardia, is effective in CCHD patients. The limitations are limited vascular access and the risk of atrioventricular block.
In Situ Initiation of East Pacific Easterly Waves in a Regional Model
Authors: Rydbeck Adam V. , Maloney Eric D. , Alaka Ghassan J. 
Published: November 2016

Abstract
The in situ generation of easterly waves (EWs) in the east Pacific (EPAC) is investigated using the Weather Research and Forecasting (WRF) Model. The sensitivity of the model to the suppression of EW forcing by locally generated convective disturbances is examined. Specifically, local forcing of EWs is removed by reducing the terrain height in portions of Central and South America to suppress robust sources of diurnal convective variability, most notably in the Panama Bight. High terrain contributes to the initiation of mesoscale convective systems in the early morning that propagate westward into the EPAC warm pool. When such mesoscale convective systems are suppressed in the model, EW variance is significantly reduced. This result suggests that EPAC EWs can be generated locally in association with higher-frequency convective disturbances, and these disturbances are determined to be an important source of EPAC EW variability. However, EPAC EW variability is not completely eliminated in such sensitivity experiments, indicating the importance for other sources of EW forcing, namely, EWs propagating into the EPAC from West Africa. Examination of the EW vorticity budget in the model suggests that nascent waves are zonally elongated and amplified by horizontal advection and vertical stretching of vorticity. Changes in the mean state between the control run and simulation with reduced terrain height also complicate interpretation of the results.
Generation of Gravity Waves by Singular Potential Vorticity Disturbances in Shear Flows
Authors: Kalashnik Maxim V. , Chkhetiani Otto 
Published: November 2016

Abstract
The linear mechanism of generation of gravity waves by potential vorticity (PV) disturbances in flows with constant horizontal and vertical shears is studied. The case of the initial singular distribution of PV, in which the PV is localized in one coordinate and is periodic with respect to other coordinates, is considered. In a stratified rotating medium, such a distribution induces a vortex wave (continuous mode), the propagation of which is accompanied by the emission of gravity waves. To find the emission characteristics, a linearized system of dynamical equations is reduced to wave equations with sources that are proportional to the initial distributions of PV. The asymptotic solutions of the equations are constructed for small Rossby numbers (horizontal shear) and large Richardson numbers (vertical shear). When passing through the inertial levels symmetrically located with respect to a vortex source, the behavior of the solutions for wave amplitudes radically changes. Directly in the vicinity of the source, the solutions are of monotonic character, corresponding to a quasigeostrophic vortex wave. At long distances from the source, the solutions oscillate. The horizontal momentum flux and the Eliassen–Palm flux are estimated using asymptotic solutions. It is found that, within the indicated range of both Rossby and Richardson numbers, these fluxes are exponentially small: that is, the emission of waves is weak.
Why Do LES of Langmuir Supercells Not Include Rotation?
Authors: Grosch C. E. , Gargett A. E. 
Published: November 2016

AbstractExisting large-eddy simulations (LES) of Langmuir supercells (LS) do not include rotational terms. Despite the fact that the actual coastal ocean is certainly affected by rotation, such simulations are found to provide excellent agreement with a wide range of features of LS observed in the shallow coastal ocean. This note explains why it is indeed acceptable to compare results of a nonrotational LES of LS in a laterally unbounded domain with observations of LS made in a rotating fluid with a lateral boundary.
Uptake of recommended common reference intervals for chemical pathology in Australia
Authors: Jones Graham RD , Koetsier Sabrina 
Published: November 2016

Background Reference intervals are a vital part of reporting numerical pathology results. It is known, however, that variation in reference intervals between laboratories is common, even when analytical methods support common reference intervals. In response to this, in Australia, the Australasian Association of Clinical Biochemists together with the Royal College of Pathologists of Australasia published in 2014 a set of recommended common reference intervals for 11 common serum analytes (sodium, potassium, chloride, bicarbonate, creatinine male, creatinine female, calcium, calcium adjusted for albumin, phosphate, magnesium, lactate dehydrogenase, alkaline phosphatase and total protein). Methods Uptake of recommended common reference intervals in Australian laboratories was assessed using data from four annual cycles of the RCPAQAP reference intervals external quality assurance programme. Results Over three years, from 2013 to 2016, the use of the recommended upper and lower reference limits has increased from 40% to 83%. Nearly half of the intervals in use by enrolled laboratories in 2016 have been changed in this time period, indicating an active response to the guidelines. Conclusions These data support the activities of the Australasian Association of Clinical Biochemists and Royal College of Pathologists of Australasia in demonstrating a change in laboratory behaviour to reduce unnecessary variation in reference intervals and thus provide a consistent message to doctor and patients irrespective of the laboratory used.
Tris-acryl gelatin microspheres versus gelatin sponge particles in uterine artery embolization for leiomyoma
Authors: Katsumori Tetsuya , Miura Hiroshi , Arima Hisatomi , Hino Akihiko , Tsuji Yusuke , Masuda Yoko , Nishimura Takeshi 
Published: November 2016

Background Tris-acryl gelatin microspheres (TAGM) and gelatin sponge particles (GS) have been used in uterine artery embolization (UAE) for leiomyoma. No direct comparisons of both embolic agents have been reported. Purpose To compare the outcomes of UAE with TAGM with those of UAE with GS for uterine leiomyoma. Material and Methods This was a non-randomized, single-institute, non-inferiority study. Between July 2008 and August 2015, 67 consecutive patients with symptomatic leiomyoma underwent UAE. GS was used for the first 49 patients and TAGM was used for the following 18 patients. The primary endpoint was tumor infarction on contrast-enhanced magnetic resonance imaging (MRI) 1 week after UAE. The secondary endpoints were changes in symptoms and quality-of-life scores with UFS-QOL questionnaires at 4 months, and adverse events (AEs) in the 4 months after UAE. Results The baseline characteristics of both groups were similar. Complete or nearly complete tumor infarction (≥90%) was achieved in 94.4% (17/18) of the TAGM group and 93.6% (44/47) of the GS group. This difference (0.8%; 95% CI, –11.9% to 13.5%) indicated the non-inferiority of the TAGM group to the GS group, with a pre-specified non-inferiority margin of 20%. No significant differences were observed in improvements in symptoms or quality-of-life scores at 4 months ( P = 0.56 and P = 0.19) or in 4-month AEs ( P = 0.29). Conclusion The outcomes of UAE with TAGM were comparable to those of UAE with GS, suggesting that both embolic agents are acceptable for the treatment of leiomyoma.
Prognostic impact of pleural effusion in acute pulmonary embolism
Authors: Kiris Tuncay , Yazıcı Selçuk , Koc Ali , Köprülü Cinar , Ilke Akyildiz Zehra , Karaca Mustafa , Nazli Cem , Dogan Abdullah 
Published: November 2016

Background Pulmonary embolism (PE) is a common and life-threatening condition associated with considerable morbidity and mortality. Pleural effusion occurs in about one in three cases; however, data on its prognostic value are scarce. Purpose To investigate the association between pleural effusion and both 30-day and long-term mortality in patients with acute PE. Material and Methods We retrospectively evaluated 463 patients diagnosed with acute PE using computed tomography pulmonary angiography (CTPA). Echocardiographic, demographic, and laboratory data were collected. The study population was divided into two groups: patients with and without pleural effusions. Pleural effusion detected on CT was graded as small, moderate, and large according to the amount of effusion. The predictors of 30-day and long-term total mortality were analyzed. Results Pleural effusions were found in 120 patients (25.9%). After the 30-day follow-up, all-cause mortality was higher in acute PE patients with pleural effusions than in those without (23% versus 9%, P < 0.001). Also, patients with pleural effusions had significantly higher incidence of long-term total mortality than those without pleural effusions (55% versus 23%, P < 0.001). In a multivariate analysis, pleural effusion was an independent predictor of 30-day and long-term mortality (odds ratio [OR], 2.154; 95% confidence interval [CI], 1.186–3.913; P = 0.012 and OR, 1.591; 95% CI, 1.129–2.243; P = 0.008, respectively). Conclusion Pleural effusion can be independently associated with both 30-day and long-term mortality in patients with acute PE.
Evaluation of sacroiliac joint MRI for pelvic venous congestion signs in women clinically suspected of sacroiliitis
Authors: Cimsit Canan , Yoldemir Tevfik , Tureli Derya , Aribal Mustafa Erkin 
Published: November 2016

Background Pelvic congestion syndrome (PCS) is a commonly overlooked condition which is a potential cause of chronic pelvic pain. Magnetic resonance imaging (MRI) of the sacroiliac joint (SIJ) may demonstrate unexpected conditions that can mimic sacroiliitis (SI). Awareness of MRI-defined pelvic venous congestion (PVC) may help in identifying PCS, where vascular abnormality may be the sole manifestation of SIJ pain. Purpose To detect incidental MRI-defined PVC in patients who underwent SIJ-MRI for presumed SI and define the variance of its incidence. Material and Methods A total of 870 women who underwent SIJ-MRI were retrospectively evaluated. Incidental findings of PVC and other genitourinary and musculoskeletal system disorders were documented. Results Of the 774 included patients, 37% demonstrated incidentally detected imaging findings related to the genitourinary system, musculoskeletal system, and PVC. The prevalence of MRI-defined PVC signs was higher in patients without SI than with SI. The prevalence of musculoskeletal disorders was higher in patients with SI whereas prevalence for genitourinary disorders was similar. Binary logistic regression analysis revealed a statistically significant correlation between SI–PVC and SI–genitourinary disorders but not between SI–musculoskeletal disorders pairs ( P = 0.001, 0.001, and 0.057 > 0.05). The probability of observing SI in SIJ-MRI is positively correlated with the absence of PVC or genitourinary disorders. Conclusion Patients who underwent MRI for presumed SI demonstrated incidental PVC as well as other genitourinary and musculoskeletal findings. An awareness of these imaging findings can help identify PVC and may draw clinicians’ attention to the possibility of PCS.
Segment-by-segment assessment of left ventricular myocardial affection in Anderson-Fabry disease by non-enhanced T1-mapping
Authors: Walter Thula C , Knobloch Gesine , Canaan-Kuehl Sima , Greiser Andreas , Sandek Anja , Blaschke Daniela , Denecke Timm , Hamm Bernd , Makowski Marcus R 
Published: November 2016

Background Anderson-Fabry disease (AFD) is an X-linked lysosomal enzyme disorder associated with an intracellular accumulation of sphingolipids, which shorten myocardial T1 relaxation times. Myocardial affection, however, varies between different segments. Purpose To evaluate the specific segmental distribution and degree of segmental affection in AFD patients. Material and Methods Twenty-five patients with AFD, 14 patients with hypertrophic cardiomyopathy (HCM), and 21 controls were included. A Modified Look-Locker Inversion Recovery sequence (MOLLI) was used for non-enhanced T1 mapping at 1.5 T in addition to standard cardiac imaging in 10–12 short axis views. T1 values were evaluated with a mixed model ANOVA and regression analysis to determine the best diagnostic cutoff values for T1 for each myocardial segment. Results Regression analysis showed the best diagnostic cutoff compared to controls in cardiac segments 1–4, 8–9, and 14. Mean differences between T1 for AFD versus HCM were greatest in segment 3, 4, and 9 (99 ms, 103 ms, 86 ms, respectively). Overall T1 times were 888 ± 70 ms and 903 ± 14 ms (AFD with and without LVH); 1014 ± 17 ms and 1001 ± 22 ms (HCM and controls, P < 0.05). Conclusion Myocardial segments are affected by a varying degree of T1 shortening in AFD patients. Segment-specific cutoff values allow the most specific detection and quantification of the extent of myocardial affection.
Bridging the great divide: Conspiracy theory research for the 21st century
Authors: Butter Michael , Knight Peter 
Published: November 2016

AbstractThis article starts from the observation that research on conspiracy theories is currently thriving, but that it is also fragmented. In particular there is an increasing divide between disciplines with culturalist and qualitative approaches, such as history, cultural studies and ethnology, and disciplines with quantitative and empirical approaches, such as psychology and political science. The article argues that this ‘great divide’ has to be bridged for research to arrive at a genuine understanding of conspiracy theories. As a first step in such a bridge-building process, the article engages, from the vantage point of (American) cultural studies, with research done on the other side of the divide, namely in psychology and political science. It summarizes the work done in these fields and evaluates it critically, concentrating on methodology; the assumptions about the dysfunctionality of conspiracy beliefs; the circularity of some arguments; the focus on individual rather than social and collective aspects; the lack of engagement with the definition of the phenomenon; and the neglect of cultural and historical difference. The article ends with recommendations for future collaborative research projects.
Risk of high-grade cervical dysplasia and cervical cancer in women with systemic lupus erythematosus receiving immunosuppressive drugs
Authors: Feldman C H , Liu J , Feldman S , Solomon D H , Kim S C 
Published: November 2016

Objective Prior studies suggest an increased risk of cervical cancer among women with systemic lupus erythematosus. However, the relationship with immunosuppressive drugs is not well studied in US nationwide cohorts. We compared the risk of high-grade cervical dysplasia and cervical cancer among women with systemic lupus erythematosus who started immunosuppressive drugs versus hydroxychloroquine. Methods We identified systemic lupus erythematosus patients initiating immunosuppressive drugs or hydroxychloroquine using claims data from two US commercial health plans and Medicaid (2000–2012). We used a validated claims-based algorithm to identify high-grade cervical dysplasia or cervical cancer. To account for potential confounders, including demographic factors, comorbidities, medication use, HPV vaccination status, and health care utilization, immunosuppressive drugs and hydroxychloroquine initiators were 1:1 matched on the propensity score. We used inverse variance-weighted, fixed effect models to pool hazard ratios from the propensity score-matched Medicaid and commercial cohorts. Results We included 2451 matched pairs of immunosuppressive drugs and hydroxychloroquine new users in the commercial cohort and 7690 matched pairs in Medicaid. In the commercial cohort, there were 14 cases of cervical dysplasia or cervical cancer among immunosuppressive drugs users and five cases among hydroxychloroquine users (hazard ratio 2.47, 95% CI 0.89–6.85, hydroxychloroquine = ref). In Medicaid, there were 46 cases among immunosuppressive drugs users and 29 cases in hydroxychloroquine users (hazard ratio 1.24, 95% CI 0.78–1.98, hydroxychloroquine = ref). The pooled hazard ratio of immunosuppressive drugs was 1.40 (95% CI 0.92–2.12). Conclusion Among women with systemic lupus erythematosus, immunosuppressive drugs may be associated with a greater, albeit not statistically significant, risk of high-grade cervical dysplasia and cervical cancer compared to patients receiving hydroxychloroquine alone.