bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biologic vs physiologic age in the transplant candidate
Authors: Artz Andrew S. 
Published: December 2016

Abstract
Hematopoietic cell transplantation (HCT) remains a cornerstone of treatment of many hematologic malignancies but transplant-associated morbidity and mortality limit application to older patients. Biologic or chronologic age barriers to HCT have fallen, because patients in their 8th decade of life comprise the group with the greatest rise in transplant use over the past decade. Evaluating physiologic age or general health in older transplant candidates requires a systematic approach inclusive of functional and comorbidity assessment, which typically is accomplished through geriatric assessment (GA). GA incorporates measures of comorbidity, function, nutrition, social support, and other health-related domains to better describe physiologic age. Older allogeneic transplant patients have a surprisingly high prevalence of vulnerabilities by GA prior to transplant, and significant comorbidity or functional limitations heighten the risks of transplant-related mortality. Ultimately, incorporation of physiologic age can improve estimates of nondisease life expectancy, prognostic survival after HCT, and inform HCT candidacy. Future research on the optimal tools to characterize physiologic age and appropriate interventions in the context of transplant are needed.
Undertreatment of people with major depressive disorder in 21 countries
Authors: Thornicroft Graham , Chatterji Somnath , Evans-Lacko Sara , Gruber Michael , Sampson Nancy , Aguilar-Gaxiola Sergio , Al-Hamzawi Ali , Alonso Jordi , Andrade Laura , Borges Guilherme , Bruffaerts Ronny , Bunting Brendan , de Almeida Jose Miguel Caldas , Florescu Silvia , de Girolamo Giovanni , Gureje Oye , Haro Josep Maria , He Yanling , Hinkov Hristo , Karam Elie , Kawakami Norito , Lee Sing , Navarro-Mateu Fernando , Piazza Marina , Posada-Villa Jose , de Galvis Yolanda Torres , Kessler Ronald C. 
Published: December 2016

BackgroundMajor depressive disorder (MDD) is a leading cause of disability worldwide.AimsTo examine the: (a) 12-month prevalence of DSM-IV MDD; (b) proportion aware that they have a problem needing treatment and who want care; (c) proportion of the latter receiving treatment; and (d) proportion of such treatment meeting minimal standards.MethodRepresentative community household surveys from 21 countries as part of the World Health Organization World Mental Health Surveys.ResultsOf 51 547 respondents, 4.6% met 12-month criteria for DSM-IV MDD and of these 56.7% reported needing treatment. Among those who recognised their need for treatment, most (71.1%) made at least one visit to a service provider. Among those who received treatment, only 41.0% received treatment that met minimal standards. This resulted in only 16.5% of all individuals with 12-month MDD receiving minimally adequate treatment.ConclusionsOnly a minority of participants with MDD received minimally adequate treatment: 1 in 5 people in high-income and 1 in 27 in low-/lower-middle-income countries. Scaling up care for MDD requires fundamental transformations in community education and outreach, supply of treatment and quality of services.
Type 3 Deiodinase Role on Central Thyroid Hormone Action Affects the Leptin-Melanocortin System and Circadian Activity
Authors: Wu Zhaofei , Martinez M. Elena , St. Germain Donald L. , Hernandez Arturo 
Published: December 2016

Abstract
The role of thyroid hormones (THs) in the central regulation of energy balance is increasingly appreciated. Mice lacking the type 3 deiodinase (DIO3), which inactivates TH, have decreased circulating TH levels relative to control mice as a result of defects in the hypothalamic-pituitary-thyroid axis. However, we have shown that the TH status of the adult Dio3−/− brain is opposite that of the serum, exhibiting enhanced levels of TH action. Because the brain, particularly the hypothalamus, harbors important circuitries that regulate metabolism, we aimed to examine the energy balance phenotype of Dio3−/− mice and determine whether it is associated with hypothalamic abnormalities. Here we show that Dio3−/− mice of both sexes exhibit decreased adiposity, reduced brown and white adipocyte size, and enhanced fat loss in response to triiodothyronine (T3) treatment. They also exhibit increased TH action in the hypothalamus, with abnormal expression and T3 sensitivity of genes integral to the leptin-melanocortin system, including Agrp, Npy, Pomc, and Mc4r. The normal to elevated serum levels of leptin, and elevated and repressed expression of Agrp and Pomc, respectively, suggest a profile of leptin resistance. Interestingly, Dio3−/− mice also display elevated locomotor activity and increased energy expenditure. This occurs in association with expanded nighttime activity periods, suggesting a disrupted circadian rhythm. We conclude that DIO3-mediated regulation of TH action in the central nervous system influences multiple critical determinants of energy balance. Those influences may partially compensate each other, with the result likely contributing to the decreased adiposity observed in Dio3−/− mice.
Implications of Perioperative Team Setups for Operating Room Management Decisions
Authors: Doll Dietrich , Kauf Peter , Wieferich Katharina , Schiffer Ralf , Luedi Markus M. 
Published: December 2016

BACKGROUND:
Team performance has been studied extensively in the perioperative setting, but the managerial impact of interprofessional team performance remains unclear. We hypothesized that the interplay between anesthesiologists and surgeons would affect operating room turnaround times, and teams that worked together over time would become more efficient.

METHODS:
We analyzed 13,632 surgical cases at our hospital that involved 64 surgeons and 48 anesthesiologists. We detrended and adjusted the data for potential confounders including age, American Society of Anesthesiologists physical status, and surgical list (scheduled cases of specific surgical specialties). The surgical lists were categorized as ear, nose, and throat surgery; trauma surgery; general surgery; and gynecology. We assessed the relationship between turnaround times and assignment of different anesthesiologists to specific surgeons using a Monte Carlo simulation.

RESULTS:
We found significant differences in team performances among the different surgical lists but no team learning. We constructed managerial decision tables for the assignment of anesthesiologists to specific surgeons at our hospital. We defined a decision algorithm based on these tables. Our analysis indicated that had this algorithm been used in staffing the operating room for the surgical cases represented in our data, median turnaround times would have a reduction potential of 6.8% (95% confidence interval 6.3% to 7.1%).

CONCLUSIONS:
A surgeon is usually predefined for scheduled surgeries (surgical list). Allocation of the right anesthesiologist to a list and to a surgeon can affect the team performance; thus, this assignment has managerial implications regarding the operating room efficiency affecting turnaround times and thus potentially overutilized time of a list at our hospital.
Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50
Authors: Kvainickas Arunas , Orgaz Ana Jimenez , Nägele Heike , Diedrich Britta , Heesom Kate J. , Dengjel Jörn , Cullen Peter J. , Steinberg Florian 
Published: December 2016

ABSTRACT
Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-domain-containing protein 50 (ANKRD50). Here, we firmly establish ANKRD50 as a new and essential component of the SNX27–retromer–WASH super complex. Depletion of ANKRD50 in HeLa or U2OS cells phenocopied the loss of endosome-to-cell-surface recycling of multiple transmembrane proteins seen upon suppression of SNX27, retromer or WASH-complex components. Mass-spectrometry-based quantification of the cell surface proteome of ANKRD50-depleted cells identified amino acid transporters of the SLC1A family, among them SLC1A4, as additional cargo molecules that depend on ANKRD50 and retromer for their endocytic recycling. Mechanistically, we show that ANKRD50 simultaneously engages multiple parts of the SNX27–retromer–WASH complex machinery in a direct and co-operative interaction network that is needed to efficiently recycle the nutrient transporters GLUT1 (also known as SLC2A1) and SLC1A4, and potentially many other surface proteins.
Meditative music listening to reduce state anxiety in patients during the uptake phase before positron emission tomography (PET) scans
Authors: Lee Wen-Li , Sung Huei-Chuan , Liu Shu-Hsin , Chang Shu-Min 
Published: November 2016

Objective:
This study examines the effects of listening to meditative music on state anxiety and heart rate variability (HRV) of patients during the uptake phase before positron emission tomography (PET) scans.

Methods:
A two-group randomized experimental design was used. Eligible patients were randomly assigned to either the experimental or control group. All patients received baseline assessments of state anxiety using Spielberger State-Trait Anxiety Inventory (STAI-S) and HRV before receiving an intravenous injection of radiopharmaceutical fluorine-18 fludeoxyglucose in the uptake room. The experimental group (n = 35) listened individually to 30 min of meditative music, integrating Chinese “Chi” and western frequency resonation in the uptake room. The control group (n = 37) lay on bed quietly for 40 min in the uptake room without music. All patients were assessed for their anxiety level and HRV again, before receiving PET scanning as post-test.

Results:
The results indicated that patients in the experimental group showed a significant reduction in state anxiety and heart rate, and increase on high frequency norm of HRV (p &lt; 0.001). There was a statistically significant reduction on anxiety level (p &lt; 0.001), heart rate (p &lt; 0.001) and high frequency norm (p = 0.001) in the experimental group compared with those of the control group.

Conclusion:
Listening to meditative music as a non-invasive and cost-effective strategy can help maximize efforts to promote comfort and relaxation for patients awaiting stressful procedures, such as PET scans. Meditative music can be effective in alleviating state anxiety of patients during the uptake phase before PET scans.

Advances in knowledge:
The study provides scientific evidence of the effects of listening to meditative music for reducing state anxiety in patients during the uptake phase before PET scans. It may have the potential to lower the risk of unwanted false-positive fluorine-18 fludeoxyglucose uptake in normal organs and to further improve image quality and image interpretation. Listening to meditative music is a safe and inexpensive intervention which can be incorporated into routine procedures to reduce anxiety of patients undergoing PET scans.
Holistic care following a palliative Hartmann's procedure
Authors: Webb Hannah 
Published: November 2016

Care study Alan, a terminally ill patient, underwent a palliative Hartmann's procedure for recurrent colorectal cancer. He recovered well from the surgery; his wound was clean with no evidence of infection, although he complained of some pain. A stoma therapist helped Alan come to terms, both physically and emotionally, with the presence of his stoma. On his fifth postoperative day his urinary catheter was removed and he was able to micturate without complication. His wound sutures were removed 5 days later. Alan kept up a positive self-image throughout and appeared to have few psychological problems with regard to his newly formed stoma. However, towards the end of his hospital stay, he expressed concern as to how he would cope on release. Alan was encouraged to maintain his roles of father and husband; he was as yet undecided about returning to work. To ensure continued help at home, he was referred to the home care team at his local hospice.
Implementation of a Pharmacist-Directed Antimicrobial Stewardship Protocol Utilizing Rapid Diagnostic Testing
Authors: Heyerly Angel , Jones Ron , Bokhart Gordon , Shoaff Mary , Fisher Douglas 
Published: December 2016

Background Rapid identification of gram-positive bacteria and resistance determinants from blood cultures can reduce the time to optimal antibiotic therapy. Objective This study evaluates the use of technology to rapidly identify gram-positive bacteria in combination with a pharmacist-directed antimicrobial stewardship protocol in a tertiary-care facility. Methods Rapid diagnostic testing was performed on gram-positive blood cultures. Pharmacists were instructed to notify prescribers of results and recommend appropriate antimicrobial therapy based on targeted treatment chart. The primary outcomes were mean time to optimal antibiotic therapy, mean time antibiotics were avoided before traditional culture results, and percent of patients with time to optimal antibiotic therapy reached in less than or equal to 2 hours. Results Inclusion criteria were met for 297 patients. Mean time to identify bacteria was 26.8 hours with nucleic acid assay versus 75.3 hours with traditional culture (difference = 48.5 hours, p < .0001). The rapid identification of gram-positive bacteria combined with accepted pharmacist intervention improved time to optimal antibiotic therapy (8.4 vs 15.4 hours, p = .0095). When contaminants were identified, antibiotics were avoided for 39.5 hours before traditional culture with pharmacist intervention versus 37.2 hours ( p > .05). Antibiotic change occurred in less than or equal to 2 hours in more patients in the pharmacist intervention group (28% vs 10.5%, p = .0002). Conclusions Rapid identification combined with pharmacist intervention significantly improved time to optimal antibiotic therapy and significantly increased the number of patients receiving optimal antibiotic therapy in less than or equal to 2 hours over rapid identification alone. A pharmacist-directed protocol combined with rapid identification enhanced antimicrobial stewardship.
„Treiben wir oder werden wir getrieben“ – Wissenschaftliche Bibliotheken im Wandel
Authors: Neuhausen Hubertus 
Published: December 2016

Zusammenfassung:
Der vorliegende Beitrag versucht zu zeigen, dass sich die Frage, ob die wissenschaftlichen Bibliotheken den Wandel gestalten oder von ihm getrieben werden, ohne weiteres dahingehend beantworten lässt, dass wir, die wissenschaftlichen Bibliotheken, von einer Reihe von Entwicklungen getrieben werden, die im Folgenden vorgestellt werden. Allerdings laufen wir auf Grund unseres Binnenerlebens in den Bibliotheken Gefahr, gar nicht wahrzunehmen, wie stark der Veränderungsdruck von außen ist. Infolgedessen steht zu befürchten, den Anschluss an die „Welt um uns herum“ zu verlieren und nicht mehr als relevante Einrichtungen wahrgenommen zu werden. Für die Zukunft der wissenschaftlichen Bibliotheken wird es ausschlaggebend sein, dass sie angemessene Antworten auf die beschriebenen Entwicklungen finden und sich als Serviceeinrichtungen profilieren, die einen kleinen, aber wesentlichen Beitrag zum Erfolg der Hochschulen beitragen, zu denen sie gehören.
GA based optimal planning of VAR sources using Fast Voltage Stability Index method
Authors: Bhattacharyya Biplab , Rani Shweta , Vais Ram Ishwar , Bharti Indradeo Pratap 
Published: November 2016

Abstract
This paper presents a novel approach for reactive power planning of a connected power network. Reactive power planning is nothing but the optimal usage of all reactive power sources i.e., transformer tap setting arrangements, reactive generations of generators and shunt VAR compensators installed at weak nodes. Shunt VAR compensator placement positions are determined by a FVSI (Fast Voltage Stability Index) method. Optimal setting of all reactive power reserves are determined by a GA (genetic algorithm) based optimization method. The effectiveness of the detection of the weak nodes by the FVSI method is validated by comparing the result with two other wellknown methods of weak node detection like Modal analysis and the L-index method. Finally, FVSI based allocation of VAR sources emerges as the most suitable method for reactive power planning.
A closed-loop power controller model of series-resonant-inverter-fitted induction heating system
Authors: Pal Palash , Roy Debabrata , Datta Avik , Sadhu Pradip K. , Banerjee Atanu 
Published: November 2016

Abstract
This paper presents a mathematical model of a power controller for a high-frequency induction heating system based on a modified half-bridge series resonant inverter. The output real power is precise over the heating coil, and this real power is processed as a feedback signal that contends a closed-loop topology with a proportional-integral-derivative controller. This technique enables both control of the closed-loop power and determination of the stability of the high-frequency inverter. Unlike the topologies of existing power controllers, the proposed topology enables direct control of the real power of the high-frequency inverter.
An elliptic equation with an indefinite sublinear boundary condition
Authors: Ramos Quoirin Humberto , Umezu Kenichiro 
Published: December 2016

Abstract
We investigate the problem

{

-

Δ
⁢
u

=

|
u
|

p
-
2

⁢
u

in
Ω

,

∂
⁡
u

∂
⁡
𝐧

=

λ
⁢
b
⁢

(
x
)

⁢

|
u
|

q
-
2

⁢
u

on

∂
⁡
Ω

,

\left\{\begin{aligned} \displaystyle-\Delta u&\displaystyle=\lvert u\rvert^{p-%
2}u&&\displaystyle\phantom{}\text{in ${\Omega}$},\\
\displaystyle\frac{\partial u}{\partial\mathbf{n}}&\displaystyle=\lambda b(x)%
\lvert u\rvert^{q-2}u&&\displaystyle\phantom{}\text{on ${\partial\Omega}$},%
\end{aligned}\right.

where Ω is a bounded and smooth domain of

ℝ
N

{\mathbb{R}^{N}}

(

N
≥
2

{N\geq 2}

),

1
<
q
<
2
<
p

{1<q<2<p}

,

λ
>
0

{\lambda>0}

, and

b
∈

C

1
+
α

⁢

(

∂
⁡
Ω

)

{b\in C^{1+\alpha}(\partial\Omega)}

for some

α
∈

(
0
,
1
)

{\alpha\in(0,1)}

. We show that

∫

∂
⁡
Ω

b

<
0

{\int_{\partial\Omega}b<0}

is a necessary and sufficient condition for the existence of nontrivial non-negative solutions of this problem. Under the additional condition

b
+

≢
0

{b^{+}\not\equiv 0}

we show that for

λ
>
0

{\lambda>0}

sufficiently small this problem has two nontrivial non-negative solutions which converge to zero in

C
⁢

(

Ω
¯

)

{C(\overline{\Omega})}

as

λ
→
0

{\lambda\to 0}

. When

p
<

2
*

{p<2^{*}}

we also provide the asymptotic profiles of these solutions.
Aufstiegsfortbildung und Karriere – Quo vadis?
Authors: Hall Anja 
Published: December 2016

ZusammenfassungDas Verhältnis von beruflicher und akademischer Bildung hat sich im Zuge der Hochschulreform verschoben. Der vorliegende Beitrag analysiert für die Abschlusskohorten 2000-2005 und 2006-2011 jeweils maximal sechs Jahre nach ihrem Abschluss die Verwertungschancen beruflicher und akademischer Tertiärabschlüsse. Datenbasis sind die BIBB/BAuA-Erwerbstätigenbefragungen 2006 und 2012. Zur Abbildung der Verwertungschancen werden Lohnprämien (Bruttostundenlohn) und die beruflichen Positionen (hochqualifizierte Tätigkeiten) betrachtet. Angewendet werden lineare und logistische Regressionsmodelle auf Basis gepoolter Datensätze. Im betrachteten Zeitraum zeigen sich im Vergleich zu Personen mit dualer Berufsausbildung unverändert hohe Lohnprämien für Personen mit Aufstiegsfortbildung und sinkende Lohnprämien für Personen mit Bachelor- bzw. traditionellem FH-Abschluss.
Antioxidant activity as indicator of UV radiation and other abiotic stress factors on Agaricus bisporus (Lange/Imbach) and Sedum hybridum (L.)
Authors: Szabó A. , Geösel A. , Kókai Z. , Orbán Cs. , Töreki K. , Szőke A. 
Published: November 2016

AbstractInvestigation of stress level might be facilitated also in plant and horticultural sciences, but currently mainly morphological parameters are in use. Antioxidant activity routinely measured in food-oriented researches and several studies indirectly indicated that stress factors can influence this parameter. Our aim was to assess the potential direct indicator role of antioxidant activity in stress conditions. We measured the effects of UVB and soil-delivered stress on Agaricus bisporus and Sedum hybridum. Our results indicate that UVB slightly decreases, while the inadequate soil conditions increase antioxidant activity; hence these measurements are suitable for determining the level of stress in different living samples.
Das Märchenerzählen in Benin zwischen Tradition und Modernität
Authors: Tokponto Mensah Wekenon 
Published: November 2016

Zusammenfassung:Die afrikanische Oralliteratur zeichnet sich traditionell gesehen durch verschiedene Ausdrucksformen wie Sprichwörter, Volkslieder, Rätsel, Epen, Sagen, Mythen, Legenden und hauptsächlich durch das mündlich überlieferte Märchen aus. Unter diesen Ausdrucksformen, die im Allgemeinen als Gattungen der oralen Literatur bezeichnet werden, nahm das Märchen bei der Volksgruppe der Fon in Benin eine führende Stelle ein. Es wurde über Generationen hinweg in den Familien und speziell bei den Erzählabenden auf den Dorfplätzen durch professionelle Erzähler mündlich tradiert und gehörte als immaterielles Erbe der Vorfahren und aufgrund der von ihm vermittelten Werte zum Alltagsleben der Menschen. Der Beitrag zeigt in erster Linie, wie die Bestimmung des Begriffs Märchen bei den Fon für Verwirrung sorgt. Er verdeutlicht, wie sich das Märchen aus afrikanischer Perspektive nicht so scharf von den anderen Gattungen der Oralliteratur abhebt, wie es im europäischen Kontext der Fall ist. Ferner hebt diese Abhandlung hervor, wie das lange erhaltene, mündlich tradierte Märchenerzählen in den letzten Jahrzehnten in Benin große Veränderungen durchlaufen hat, und stellt die konkreten Hintergründe heraus, die diesem Umbruch zugrunde liegen. Zum Schluss lenkt sie das Augenmerk auf die Zukunft des Märchenerzählens in Benin.
Legislating for Same-Sex Marriage: Sophistical Effectiveness in Australian Law
Authors: Lilienthal Gary 
Published: November 2016

AbstractThis paper by-passes the various public tropes, such as “marriage equality”, and concentrates on determining whether or not a same-sex marriage law would be sophistically effective in Australia. It revives the ancient Greek sophistical rhetorical skill of proposing a law, and applies it as a critical context to the topic of legislating for same-sex marriage. The objective is to assess whether or not a same-sex marriage law will be effective in its legislative objects. It proposes to discuss whether the parliament could introduce such a law so that the law’s objects were achieved effectively in the public mind. Argument will try to show that introducing a law to create same-sex marriage would fail because of subsisting priestly legislation on the subject of marriage. Its two hypotheses are that the canon law and other English priestly legislation restrict the scope of marriage regulation, and marriage could not be re-defined to cover same-sex marriage. Sections of the paper examining the law historically employ the historiographical method of identifying underlying norms, the effect of which is occasional reverse chronologies. The article’s conclusion will assert that a statute for legal and duly registered same-sex marriage likely would be, according to sophistical rhetorical reasoning, a fiction misrepresenting the truth of the subsisting legal and social institutions of marriage.