bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Crisugabalin (HSK16149) in Adults with Postherpetic Neuralgia
Authors: Zhang Daying , Lei Tiechi , Qin Lanying , Li Chenyu , Lin Xuewu , Wang Huiping , Zhang Guoqiang , Zhang Shoumin , Shi Kemei , Li Linfeng , Yang Zhenling , Yang Xiumin , Ba Xiaohong , Gao Ying , Zhang Zhuobo , Wang Guonian , Wu Liming , Wang Yaping , Wang Yu , Zhu Shoumin , Shi Jihai , Ye Zhijian , Yang Chunjun , Liu Changyi , Zhang Tong , Lu Shousi , Yu Nan , Li Xiangkui , Han Xiuping , Chen Xiaoyan , Wan Li , Cheng Zhigang , Bai Nianyue , Jin Zhehu , Yu Chunshui , Zhang Weiyi , Lu Jianyun , Wang Dongmei , Sun Hui , Wu Wenzhong , Qin Pingping , Feng Zhiying , Chen Rixin , Zhang Tangde , Yang Dong , Yin Wenhao , Zhang Jianglin , Li Xin , Li Fangqiong , Wu Tingting , Lu Qianjin 
Published: September 2024

ImportanceChina carries a heavy burden of postherpetic neuralgia, with an unmet need for novel drugs with greater efficacy and less prominent neurotoxic effects than existing calcium channel ligands.ObjectiveTo investigate the efficacy and safety of crisugabalin, an oral calcium channel α2δ-1 subunit ligand, for postherpetic neuralgia.Design, Setting, and ParticipantsThis randomized clinical trial, carried out between November 9, 2021, and January 5, 2023, at 48 tertiary care centers across China had 2 parts. Part 1 was a phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study consisting of a 2-week screening period, a 7-day run-in period, and a 12-week double-blind treatment period. Part 2 was a 14-week open-label extension study. Investigators, statisticians, trial clinicians, and patients were blinded to trial group assignments. Participants included adults with postherpetic neuralgia with an average daily pain score (ADPS) of at least 4 on the 11-point Numeric Pain Rating Scale over the preceding week, with the exclusion of patients with pain not controlled by prior therapy with pregabalin (≥300 mg/d) or gabapentin (≥1200 mg/d).InterventionsPatients were randomized 1:1:1 to receive crisugabalin, 20 mg twice daily (ie, 40 mg/d), and crisugabalin, 40 mg twice daily (ie, 80 mg/d), or placebo for 12 weeks. Eligible patients received crisugabalin, 40 mg, twice daily during extension.Main Outcome and MeasureThe primary efficacy end point was the change from baseline in ADPS at week 12.ResultsThe study enrolled 366 patients (121 patients receiving crisugabalin, 40 mg/d; 121 patients receiving crisugabalin, 80 mg/d; 124 patients receiving placebo; median [IQR] age, 63.0 [56.0-69.0] years; 193 men [52.7%]). At week 12, the least squares mean (SD) change from baseline in ADPS was −2.2 (0.2) for crisugabalin, 40 mg/d, and −2.6 (0.2) for crisugabalin, 80 mg/d, vs −1.1 (0.2) for placebo, with a least squares mean difference of −1.1 (95% CI, −1.6 to −0.7; P &amp;lt; .001) and −1.5 (−95% CI, −2.0 to −1.0; P &amp;lt; .001) vs placebo, respectively. No new safety concerns emerged.Conclusions and RelevanceCrisugabalin, 40 mg/d, or crisugabalin, 80 mg/d, was well tolerated and demonstrated a statistically significant improvement in ADPS over placebo.Trial RegistrationClinicalTrials.gov Identifier: NCT05140863
Association of Daily Doses of Buprenorphine With Urgent Health Care Utilization
Authors: Axeen Sarah , Pacula Rosalie Liccardo , Merlin Jessica S. , Gordon Adam J. , Stein Bradley D. 
Published: September 2024

ImportanceHigher buprenorphine doses may benefit the increasing number of individuals using fentanyl and other synthetic opioids, but there is little empirical evidence on the efficacy of such higher doses.ObjectiveTo examine the association between higher buprenorphine doses (above 16 mg and 24 mg) and subsequent emergency department (ED) or inpatient service use among patients diagnosed with opioid use disorder.Design, Setting, and ParticipantsThis cross-sectional study was a retrospective analysis of health data from Optum’s deidentified Clinformatics Data Mart Database from 2016 to 2021 for commercially insured individuals aged 18 years or older diagnosed with opioid use disorder (OUD). Eligible participants initiated buprenorphine after at least 90 days of enrollment and were dispensed at least a 14-day supply of buprenorphine. Data were analyzed from September 2023 through February 2024.ExposuresMaximum buprenorphine dose received by a patient for 14 or more days: more than 24 mg, more than 16 mg to 24 mg, more than 8 mg to 16 mg, or 1 mg to 8 mg.Main Outcomes and MeasuresDays from initiation of the maximum buprenorphine dose to an ED or inpatient visit for a behavioral health diagnosis, controlling for patient demographics, comorbid conditions, time to reaching maximum dose, buprenorphine discontinuation, and pre-buprenorphine health care utilization.ResultsA total of 35 451 individuals with an OUD diagnosis who began buprenorphine treatment were identified (mean [SD] age, 46.2 [15.1] years; 20 983 male [59.2%]; 3326 Black [9.4%], 2411 Hispanic [6.8%], 26 712 White [75.3%]). The most common dose was more than 8 mg to 16 mg daily (14 802 patients [42.9%]), with 9669 patients (27.3%) in the 1 mg to 8 mg tier, 10 329 patients (29.1%) in the 8 mg to 16 mg tier, and 651 patients (1.8%) in the tier receiving more than 24 mg. Among all patients receiving buprenorphine, 12.5% experienced an ED or inpatient visit. Survival analysis shows patients receiving doses more than 24 mg and between 16 mg to 24 mg had longer times to ED or inpatient use than patients receiving from 8 mg to 16 mg (time ratio [TR], 1.11; 95% CI, 1.02 to 1.20) and more than 24 mg (TR, 1.37; 95% CI, 1.04 to 1.81). Findings for doses above 16 mg daily were consistent for observation windows as short as 365 days (more than 24 mg: TR, 1.48; 95% CI, 1.01-2.18; more than 16 mg to 24 mg: TR, 1.19; 95% CI, 1.06-1.32).Conclusions and RelevanceThese findings contribute to the sparse empirical research regarding potential benefits of higher-dose buprenorphine treatment of individuals with OUD. Clinicians should be aware of the potential effects of higher buprenorphine doses on health care utilization while policymakers work to ensure equitable access to individuals who could potentially benefit from higher doses.
Kidney Transplant Outcome Following Donation After Euthanasia
Authors: Slagter Julia S. , Kimenai Hendrikus J. A. N. , van de Wetering Jacqueline , Hagenaars Hanneke J. A. M. , Reinders Marlies E. J. , Polak Wojciech G. , Porte Robert J. , Minnee Robert C. 
Published: September 2024

ImportanceIn the Netherlands, organ donation after euthanasia (donation after circulatory death type V [DCD-V]) has been increasingly performed since 2012. However, the outcomes of DCD-V kidney grafts have not been thoroughly investigated. It is critical to assess the outcomes of these kidney grafts to ascertain whether DCD-V is a safe and valuable way to increase the kidney donor pool.ObjectivesTo investigate the outcomes of DCD-V kidney transplantation and compare them with outcomes of kidney transplantation after circulatory death after withdrawal of life-sustaining therapies (DCD type III [DCD-III]) and donation after brain death (DBD).Design, Setting, and ParticipantsA retrospective cohort study was conducted using the database from the Dutch Transplant Foundation. All kidney transplants in the Netherlands between January 2012 (start of the euthanasia program) and July 2023 were included. Follow-up was obtained through 5 years after transplantation. Data analysis was performed from November 2023 until February 2024.ExposuresKidney transplantation with a DCD-V graft compared with DCD-III and DBD grafts.Main Outcomes and MeasuresThe primary outcome was death-censored graft survival until 5 years after transplantation. Secondary outcomes were the incidence of delayed graft function (DGF), permanent nonfunction (PNF), serum creatinine concentration, and patient survival until 5 years after kidney transplantation.ResultsA total of 145 DCD-V kidney transplants were compared with 1936 DCD-III and 1255 DBD kidney transplants. Median (IQR) recipient age was 59 (46-66) years in the DCD-V cohort, compared with 61 (50-68) years in the DCD-III cohort and 61 (50-68) years in the DBD cohort. The incidence of DGF with DCD-V kidney transplants (26%) was significantly less than that with DCD-III kidney transplants (49%; P &amp;lt; .001) and similar to that with DBD kidney transplants (22%; P = .46). PNF occurrence with DCD-V kidneys (6%) was similar to that with DCD-III kidneys (6%; P = .79) and higher than in DBD kidneys (4%; P &amp;lt; .001). There was no difference in 5-year death-censored graft survival between DCD-V grafts (82%) and DCD-III (86%; P = .99) or DBD (84%; P = .99) grafts. There was no difference in 5-year patient survival between DCD-V kidney transplants (69%) and DCD-III (76%; P = .45) or DBD (73%; P = .74) kidney transplants. A propensity score analysis was performed to match the DCD-V and DCD-III cohort, showing results similar to those of the unmatched cohort.Conclusions and RelevanceThis study found that DCD-V kidney transplantation yielded a lower incidence of DGF compared with DCD-III kidney transplantation and yielded long-term results similar to those of DCD-III and DBD kidney transplantation. The findings suggest that DCD-V is a safe and valuable way to increase the kidney donor pool.
Thinking through the social world: Further exploring the direct, moderated, and mediated relationship between need for cognition and aggression
Authors: Barlett Christopher P. 
Published: September 2024

AbstractFindings from a paucity of research suggest that need for cognition (NFC) is negatively correlated with trait aggression. The correlational nature of the data juxtaposed with the reliance on assessing trait aggression negates causal claims regarding this relationship. The objective of the current research to expand our understanding of the relationship between NFC and aggression in the following ways: (1) focus on state, rather than trait, aggressive behavior, (2) examine the role of provocation, and (3) test the mediating influence of state anger and revenge motives. Our study had US emerging adult participants randomly assigned to be provoked or not before completing measures of anger, revenge motives, and aggression. Results showed that only revenge motives mediated the relationship between NFC and aggression, which was found to be significant only for provoked participants. Results are discussed in theoretical and practical implications.
A General Method for Calibration of Active Scanning Thermal Probes
Authors: Tselev Alexander 
Published: September 2024

Scanning thermal microscopy (SThM) is a scanning probe technique aimed at quantitative characterization of local thermal properties at the length scale down to tens of nanometers. With many probe designs and approaches to interpretation of probe responses, there is a need for a universal framework, which would allow probe calibration and comparison of probe performance. Herein, a calibration framework based on an abstracted, formal, probe model for active SThM probes is developed. The calibration can be accomplished through measurements with two or three calibration samples. Requirements for calibration samples are described with examples of structures of suitable samples identified in published literature. A link to a published experimental work indirectly verifying the proposed procedure is provided. The calibration does not require knowledge of internal probe properties and yields a small and universal set of parameters that can be used to quantify thermal resistance presented to the probe by samples as well as to characterize active‐mode SThM probes of any type and at any measurement frequency. How the probe calibration parameters can be used to guide probe design is illustrated. When the calibration approach can be used directly to measure the thermal conductivity of unknown samples is also analyzed.
Synthesis of Quinone‐Amine‐Linked Covalent Organic Frameworks for Boosting the Photocatalytic Removal of Uranium
Authors: Pei Xiang , He Pan , Yu Kaifu , Li Yang , Tang Ya , Ma Lijian 
Published: September 2024

AbstractCompared to imine covalent organic frameworks (COFs), the superior stability of amine‐linked COFs renders them more suitable for long‐term harsh real‐world environments. Their numerous amine sites can serve as functional groups or be subjected to post‐modification to further enhance the performance of the material. However, the assortment and abundance of amine‐linked COFs via currently lacking due to restricted monomer varieties and synthetic methods. Herein, this study presents an innovative approach for synthesizing quinone‐amine‐linked COFs by directly combining 2,5‐dihydroxy‐1,4‐benzoquinone (DHBQ) with various amine monomers and introduce a novel photocatalyst, DHBQ‐TAPP‐COF, specifically tailored to efficiently reduce uranium in harsh environments. DHBQ‐TAPP‐COF features a unique donor–acceptor structure, with the DHBQ units serving as acceptors because they contain abundant oxygen atoms that facilitate metal ion coordination, thereby enhancing charge carrier separation, carrier utilization, and uranium reduction efficiency. The quinone‐amine linkages offer improved stability, extended π‐conjugation, heightened local polarity, and conductivity, which enable efficient carrier transfer within the material and thus enhance the overall performance of the uranium photocatalyst. The proposed photocatalyst can efficiently reduce U(VI) without sacrificial agents or decomposition to precipitate UO2 at a recovery rate exceeding 98%. This catalyst provides an efficient and convenient strategy for the stable and high‐performance photocatalytic reduction of uranium.
Self‐Powered and 3D Printable Soft Sensor for Human Health Monitoring, Object Recognition, and Contactless Hand Gesture Recognition
Authors: Tang Jingzhi , Gou Kai , Wang Chong , Wei Minghui , Tan Qiuli , Weng Gengsheng 
Published: September 2024

AbstractA new galvanic cell design of a self‐powered and 3D‐printable soft sensor showing health monitoring, object recognition, and contactless hand gesture recognition, is reported. The soft sensor consists of a 3D‐printed poly(acrylic acid) (PAA) hydrogel electrolyte layer, a soft anode layer, and a soft cathode layer. The anode layer is a 3D‐printed and Cu2+ cross‐linked poly(N,N‐dimethylacrylamide‐co‐3‐alanine‐2‐hydroxypropylmethacrylate) (PDA) hydrogel dispersed with Cu metal particles (PDA/Cu2+/Cu hydrogel), while the cathode layer is a bottom thin layer of the PAA hydrogel containing MnO2 (PAA/MnO2). Using graphite films as the soft electrodes, the soft sensor is finally assembled. The soft sensor has high force and temperature sensitivities. It gives different electric current responses under stretching, bending, pressing, and impact loading. The soft sensor is demonstrated to be useful in detecting human motion and physiological activities, e.g., breath. Based on the force and contactless temperature sensitivities, the soft sensor is used to recognize human hand gestures and plastic balls with different diameters. This 3D printable soft sensor with self‐powering, contactless motion capturing, and multi‐pimulus sensing capabilities illustrates a new pathway to make soft sensory devices for healthcare and human‐machine interaction applications.
Van der Waals Heterostructure Contact Strategy for Barrier‐Free 2D Complementary Transistors
Authors: Sang Pengpeng , Wang Qianwen , Wang Hai , Wu Jixuan , Zhan Xuepeng , Li Dechun , Chen Jiezhi 
Published: September 2024

AbstractIncorporating atomically thin 2D semiconductors (2DSCs) into the vertical complementary field‐effect transistors (CFETs) is of great significance in enabling devices to break through the sub‐nanometer scaling limit. However, due to the lack of effective doping technology and the difficult‐to‐control electrode interface, simultaneously realizing high‐performance p‐type and n‐type devices using a single metal electrode presents great challenges for 2D‐CFETs design. In this study, an innovative electrical contact strategy is proposed by constructing van der Waals heterojunction (vdWH) using 2DSCs to regulate the electrical contact properties between the metal electrode and 2DSC channel. First‐principles calculations reveal that degenerate or quasi‐degenerate complementary doping is achieved in a series of transition metal dichalcogenides (TMDs) by designing (quasi‐)broken‐gap vdWHs and utilizing their interlayer charge transfer. Metal‐2DSC contact barriers can be effectively regulated by introducing 2DSC intercalation and constructing vdWH. P‐type (quasi‐)Ohmic contacts are realized between Au electrode and various TMD channels, as well as between WTe2 channel and different metal electrodes. Moreover, quantum transport simulations present the remarkable on‐current over 102 µA µm−1 in both p‐type and n‐type 2D‐FETs by employing the vdWH and metal‐vdWH electrodes. The proposed vdWH strategy is applicable to various metal‐2DSC contacts and will shed light on future high‐performance 2D‐CFET integrations.
Regulating the Manganese Valence State Improves the Kinetic Properties of Manganese‐Based Cathodes
Authors: Zhang Jiahui , Yuan Haocheng , Qin Zuoyu , Ding Peipei , Yu Dengfeng , Wu Huiping , Wang Jian , Shao Yang , Zhou Weidong , Nan Ce‐Wen , Ren Yaoyu , Li Liangliang 
Published: September 2024

AbstractManganese (Mn)‐based lithium (Li)‐ion batteries with high energy density and low cost have recently attracted considerable attention. One drawback of Mn‐based batteries is the severe capacity attenuation caused by the Jahn‐Teller effect, which distorts the crystal structure and reduces the kinetics of Li‐ion insertion/extraction in the cathodes. In this study, the Mn valence state is regulated on the surface of Mn‐based oxide particles and oxygen vacancies are introduced to facilitate rapid Li‐ion transport and charge storage by adding succinonitrile (SN) to Mn‐based cathodes. Because of the reaction between SN and Mn‐based cathode particles, the contents of Mn3+ ions and oxygen vacancies increase, leading to an improvement in the Li‐ion kinetic properties of the cathodes as well as a reduction in the dissolution of Mn from the cathodes. By regulating the Mn valence state, Li‐ion and Li metal batteries with LiMn2O4 or Li‐rich Mn‐based layered oxide cathodes show significantly enhanced discharge capacity and improved cyclic performance. This study demonstrates that regulating the valence state of Mn ions is an effective strategy for enhancing the electrochemical performance of Mn‐based Li batteries and that adding SN to the cathodes is a cost‐effective method for mass production.
Boosting the Anode and Cathode Stability Simultaneously by Interfacial Engineering via Electrolyte Solvation Structure Regulation Toward Practical Aqueous Zn‐ion Battery
Authors: Wang Panpan , Zhong Yi , Wang Jiasen , Zhou Huiqin , Sun Gang , Sui Xulei , Wang Zhenbo 
Published: September 2024

AbstractThe application of zinc‐ion batteries (ZIBs) is seriously challenged by the poor stability of Zn anode and cathode in aqueous solution, which is closely associated with electrolyte structure and water reactivity. Herein, the stability issues both for the cathode and anode can be simultaneously addressed via tuning the electrolyte solvation structure in hybrid electrolyte with tripropyl phosphate (TPP) as co‐solvent. On the Zn anode, a robust poly‐inorganic solid electrolyte interphase (SEI) layer comprised of Zn3(PO4)2‐ZnS‐ZnF2 species is in situ formed, effectively suppressing parasitic reaction and dendrite evolution. For V2O5 cathode, the notorious vanadium dissolution is effectively restricted with improved structure stability achieved. The optimized electrolyte facilitates the reversible redox kinetics both at the cathode and Zn anode. Consequently, Zn||Zn cells display extended cycling lifespans over 3000 h at 1 mA cm−2, 1 mAh cm−2. Zn||V2O5 full cells deliver a high reversible capacity of 261.8 mAh g−1 and hold retention of 73.6% upon 500 cycles even operated in harsh conditions with thin Zn anode (10 µm) and low negative/positive (N/P) ratio of ≈4.3, which also showcase impressive performance with regard to rate and storage performance, further emphasizing the potential of electrolyte regulation tactics in advancing the commercialization of ZIBs.
Glucose Oxidase‐Immobilized Dually‐Crosslinked Nanogels for Rapid‐Responsive Insulin Delivery
Authors: Ma Yuhong , Yang Jingru , Ma Yukun , Yang Rui , Han Fuwei , He Mujiao , Liu Wei , Qian Hongliang , Chen Wei , Huang Dechun 
Published: September 2024

AbstractDespite the potential benefits of close‐looped insulin delivery systems in regulating glycemic homeostasis and effectively alleviating diabetes, they still encounter challenges such as limited effectiveness in preventing low glycemic episodes due to sluggish glucose response, and issues with the instability of enzymes and carriers. In this study, dually‐crosslinked and glucose oxidase (GOx)‐immobilized insulin nanogels (DC‐NGs@Ins) are developed for rapid‐responsive and sustained hypoglycemic therapy. The DC‐NGs@Ins with the phenylborate ester linker enabled the insulin release in a close‐looped fashion, and moreover, immobilized GOx‐generated hydrogen peroxide (H2O2) by consuming the glucose, which can further bind to phenylborate ester for enhancing glucose response and accelerating the insulin release. The dually‐crosslinked structure (phenylboronic ester and UV‐crosslinking) effectively minimized the initial burst release of insulin, thus preventing the potential risk of hypoglycemia. More interestingly, GOx immobilized in the nanogels mitigated GOx leakage and enhanced its multiple utilization compared to free GOx. In vivo study demonstrated that DC‐NGs@Ins effectively maintained glycemic levels (BGLs) below 200 mg dL−1 for at least 8 h compared to singly‐crosslinked nanogels (SC‐NGs@Ins). Therefore, this intelligent insulin delivery system shows potential applications in diabetes treatment.
Peroxidase‐Mimetic Iron Silicate Nanosheets Coordinated with Indocyanine Green for Enhanced Anti‐Tumor Therapy
Authors: Zhu Shuairu , Xu Hongwei , Guo Wanying , Yang Mei , Tan Huiling , Hou Shaosong , Yao Jie , Luo Han , Yao Yongchao , Zhao Jingxiang , Wei Yonggang , Sun Xuping , Ying Binwu 
Published: September 2024

AbstractThe versatile element composition and multifunctional properties of biodegradable silicates have attracted significant attention in cancer therapeutics. However, their application as nanozymes is often limited by suboptimal catalytic efficiency and insufficient intratumoral retention. In this study, the hydrothermal synthesis of iron silicate (FeSi) nanosheets are reported exhibiting exceptional peroxidase (POD)‐like activity (136.7 U mg−1), outperforming most reported iron‐based nanozymes. Density functional theory calculations revealed that the introduction of Si into the catalyst enhances H2O2 adsorption and dissociation of Fe sites, leading to superior POD performance. Furthermore, the FeSi nanosheets are modified with Indocyanine Green (ICG) to facilitate targeted aggregation‐potentiated therapy. The integration of ICG improved tumor penetration and retention of the FeSi nanosheets, significantly increasing their reactive oxygen species production and bolstering therapeutic efficacy.