bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling
Authors: Berair Rachid , Hartley Ruth , Mistry Vijay , Sheshadri Ajay , Gupta Sumit , Singapuri Amisha , Gonem Sherif , Marshall Richard P. , Sousa Ana R. , Shikotra Aarti , Kay Richard , Wardlaw Andrew , Bradding Peter , Siddiqui Salman , Castro Mario , Brightling Christopher E. 
Published: May 2017

Airway remodelling in asthma remains poorly understood. This study aimed to determine the association of airway remodelling measured on bronchial biopsies with 1) lung function impairment and 2) thoracic quantitative computed tomography (QCT)-derived morphometry and densitometry measures of proximal airway remodelling and air trapping.Subjects were recruited from a single centre. Bronchial biopsy remodelling features that were the strongest predictors of lung function impairment and QCT-derived proximal airway morphometry and air trapping markers were determined by stepwise multiple regression. The best predictor of air trapping was validated in an independent replication group.Airway smooth muscle % was the only predictor of post-bronchodilator forced expiratory volume in 1 s (FEV1) % pred, while both airway smooth muscle % and vascularity were predictors of FEV1/forced vital capacity. Epithelial thickness and airway smooth muscle % were predictors of mean segmental bronchial luminal area (R2=0.12; p=0.02 and R2=0.12; p=0.015), whereas epithelial thickness was the only predictor of wall area % (R2=0.13; p=0.018). Vascularity was the only significant predictor of air trapping (R2=0.24; p=0.001), which was validated in the replication group (R2=0.19; p=0.031).In asthma, airway smooth muscle content and vascularity were both associated with airflow obstruction. QCT-derived proximal airway morphometry was most strongly associated with epithelial thickness and airway smooth muscle content, whereas air trapping was related to vascularity.
Perspectives of patients and healthcare professionals on mHealth for asthma self-management
Authors: Simpson Andrew J. , Honkoop Persijn J. , Kennington Erika , Snoeck-Stroband Jiska B. , Smith Ian , East Jessica , Coleman Courtney , Caress Ann , Chung Kian Fan , Sont Jacob K. , Usmani Omar , Fowler Stephen J. 
Published: May 2017

Mobile healthcare (mHealth) has the potential to revolutionise the self-management of long-term medical conditions such as asthma. A user-centred design is integral if mHealth is to be embraced by patients and healthcare professionals.The aim of this study was to determine the perspectives of individuals with asthma and healthcare professionals on the use of mHealth for asthma self-management.We used a sequential exploratory mixed methods design; focus groups informed the development of questionnaires, which were disseminated to individuals with asthma and healthcare professionals.Focus group participants (18 asthma patients and five healthcare professionals) identified 12 potential uses of mHealth. Questionnaire results showed that individuals with asthma (n=186) most frequently requested an mHealth system to monitor asthma over time (72%) and to collect data to present to healthcare teams (70%). In contrast, healthcare professionals (n=63) most frequently selected a system alerting patients to deteriorating asthma control (86%) and advising them when to seek medical attention (87%). Individuals with asthma were less likely than healthcare professionals (p<0.001) to believe that assessing medication adherence and inhaler technique could improve asthma control.Our data provide strong support for mHealth for asthma self-management, but highlight fundamental differences between the perspectives of patients and healthcare professionals.
An evidence-based, point-of-care tool to guide completion of asthma action plans in practice
Authors: Kouri Andrew , Boulet Louis-Philippe , Kaplan Alan , Gupta Samir 
Published: May 2017

Asthma action plans (AAPs) reduce healthcare utilisation, improve quality of life and are recommended across guidelines. However, fewer than 25% of patients receive an AAP, partly due to prescribers' inability to complete “yellow zone” instructions (how to intensify therapy for acute loss of control). We sought to review best evidence to develop a practical, evidence-based tool to facilitate yellow zone guidance in adults.We reviewed recent asthma guidelines and adult studies addressing acute loss of asthma control (January 2010 to March 2016). We developed evidence-based rules for yellow zone therapy and operational guidelines to maximise adherence and minimise errors.We reviewed three guidelines and 11 manuscripts (2486 abstracts screened). Recommendations were comparable but some areas lacked guidance. For 15/43 asthma regimens, the commonly recommended four- to five-fold yellow zone inhaled corticosteroid dose increase was problematic due to regulatory dose limits. We identified evidence-based alternatives for 8/15 regimens. Operational guidance included increasing to a maximum of four inhalations while maintaining baseline inhaler frequency and device in the yellow zone.We developed a practical implementation tool to facilitate AAP delivery at the point of care, addressing existing gaps and uncertainties. Our tool should be implemented as part of a multifaceted approach to augment AAP usage.
College students’ acceptance of online mass-customized athletic shoes
Authors: Liang Yuli , Liu Chuanlan , McRoberts Lisa Barona 
Published: May 2017

AbstractThis research intends to understand the acceptance of online mass-customized athletic shoes among college students through applying the theory of reasoned action with a focus on whether utilitarian value and need for uniqueness influence favorable attitude formation differently. The questionnaires were distributed to 260 college students in a major southeastern US university using extra class credit as participation incentive. SPSS 23.0 and SPSS Amos 23 were used in data analysis. Structural equation modeling with a path comparison were used to assess construct validity and test the proposed hypotheses and conceptual framework. Results showed that college students’ acceptance and purchase intention could be predicted by attitudes and subjective norm. In addition to perceived security of the online environment, utilitarian value and need for uniqueness equally facilitated formation of favorable attitude toward acceptance of online mass-customized athletic shoes among college students. Theoretical and practical implications, as well as the limitations of the study are further discussed.
Nonlinear gray-level co-occurrence matrix texture analysis for improved seismic facies interpretation
Authors: Di Haibin , Gao Dengliang 
Published: May 2017

Seismic texture analysis is a useful tool for delineating subsurface geologic features from 3D seismic surveys, and the gray-level co-occurrence matrix (GLCM) method has been popularly applied for seismic texture discrimination since its first introduction in the 1990s. The GLCM texture analysis consists of two components: (1) to rescale seismic amplitude by a user-defined number of gray levels and (2) to perform statistical analysis on the spatial arrangement of gray levels within an analysis window. Traditionally, the linear transformation is simply used for amplitude rescaling so that the original reflection patterns could be best preserved. However, the seismic features of interpretational interest often cover only a small portion of its amplitude histogram. For representing such features more effectively, it is helpful to perform a nonlinear rescaling of the amplitude distribution between different seismic features. To achieve such an objective, this study proposes a nonlinear GLCM analysis based on four types of nonlinear gray-level transformation (logarithmic, exponential, sigmoid, and logit) and investigates their implications for seismic facies interpretation. Applications to the 3D seismic data set from offshore Angola (West Africa) demonstrate the added values of the generated nonlinear GLCM attributes in better characterizing the channels, fans, and lobes in a deep-marine turbidite system.
Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors
Authors: Burris Howard A. , Infante Jeffrey R. , Ansell Stephen M. , Nemunaitis John J. , Weiss Geoffrey R. , Villalobos Victor M. , Sikic Branimir I. , Taylor Matthew H. , Northfelt Donald W. , Carson William E. , Hawthorne Thomas R. , Davis Thomas A. , Yellin Michael J. , Keler Tibor , Bullock Timothy 
Published: May 2017

Purpose CD27, a costimulatory molecule on T cells, induces intracellular signals that mediate cellular activation, proliferation, effector function, and cell survival upon binding to its ligand, CD70. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors. Methods In a 3 + 3 dose-escalation design (n = 25), patients received a single dose of varlilumab (0.1, 0.3, 1.0, 3.0, or 10 mg/kg intravenously) with a 28-day observation, followed by up to five multidose cycles (one dose per week for 4 weeks), depending on tumor response. Expansion cohorts were initiated at 3.0 mg/kg in patients with melanoma (n = 16) and renal cell carcinoma (RCC; n = 15). Primary objectives were to assess the safety and the maximum tolerated and optimal biologic doses of varlilumab. Secondary objectives were to evaluate the pharmacokinetics, pharmacodynamics, and clinical antitumor activity of varlilumab. Results Exposure to varlilumab was linear and dose proportional across dose groups. Only one patient experienced a dose-limiting toxicity—grade 3 transient asymptomatic hyponatremia at the 1.0-mg/kg dose level. Treatment-related adverse events were generally grade 1 or 2 in severity. Evidence of biologic activity consistent with CD27 stimulation—chemokine induction, T-cell stimulation, regulatory T cell depletion—was observed at all dose levels. A patient with metastatic RCC experienced a partial response (78% shrinkage, progression-free survival > 2.3 years). Eight patients experienced stable disease > 3 months, including a patient with metastatic RCC with progression-free survival of > 3.9 years. Conclusion Dose escalation of varlilumab to 10 mg/kg was well tolerated without identification of a maximum tolerated dose. Varlilumab was biologically and clinically active.
The utility of the radionuclide probe in parathyroidectomy for primary hyperparathyroidism
Authors: Lim MS , Jinih M , Ngai CH , Foley NM , Redmond HP 
Published: May 2017

INTRODUCTION Parathyroidectomy is the definitive treatment for primary hyperparathyroidism but the intraoperative identification of adenomas is challenging. The aim of this study was to evaluate the utility of a radionuclide probe (RNP) in addition to intraoperative parathyroid hormone ( IOPTH) measurement as an intraoperative diagnostic adjunct in patients undergoing parathyroidectomy for primary hyperparathyroidism. METHODS This was a retrospective cohort study of patients treated between 2004 and 2015 in a university affiliated teaching hospital. Patients were grouped into those with RNP use (RNP+) and those without (RNP-). The primary outcome measure was rate of operative failure, which included false positives. The diagnostic sensitivity and positive predictive value of both RNP and IOPTH were also evaluated. RESULTS A total of 298 patients were included in the study, 127 (42.6%) being in the RNP+ group and 171 (57.4%) in the RNP- group. The false positive rate for the RNP+ patients was 1.6% compared with 9.4% for RNP- patients (p=0.006, hazard ratio [HR]: 6.45). The rates of operative failure were 6.3% and 11.7% respectively (p=0.159, HR: 1.97). RNP use had a sensitivity of 92.0% and a positive predictive value of 98.3% compared with 78.6% and 95.2% respectively for IOPTH monitoring. CONCLUSIONS RNP use is associated with fewer false positives and reduced operative failure than IOPTH measurement. It also has a higher sensitivity and positive predictive value. RNP use is recommended in centres that have the required facilities.
Mechanical complications of central venous catheterisation in trauma patients
Authors: Odendaal J , Kong VY , Sartorius B , Liu TY , Liu YY , Clarke DL 
Published: May 2017

INTRODUCTION Central venous catheterisation (CVC) is a commonly performed procedure in a wide variety of hospital settings and is associated with appreciable morbidity. There is a paucity of literature focusing on mechanical complications specifically in the trauma setting. The aim of our study was to determine the spectrum of mechanical complications in a high-volume trauma centre in a developing world setting where ultrasound guidance was not available. METHODS A retrospective study was performed analysing data from a four-year period at the Pietermaritzburg Metropolitan Trauma Service in South Africa. RESULTS A total of 178 mechanical complications (18%) occurred in 1,015 patients undergoing CVC: 117 pneumothoraces, 25 malpositions, 18 catheter dislodgements, 14 arterial cannulations, one air embolism, one chylothorax, one pleural cannulation and one retained guide-wire. The internal jugular vein (IJV) approach was associated with a higher overall complication rate than the subclavian vein (SCV) approach (24% vs. 13%, p<0.001). Pneumothorax (73% vs. 57%, p<0.001) and arterial cannulation (15% vs. 0%, p<0.001) were more common with the IJV. Catheter dislodgement (21% vs. 0%, p<0.001) was more common with the SCV. Junior doctors performed 66% of the CVCs and this was associated with a significantly higher complication rate (20% vs. 12%, p<0.001). CONCLUSIONS CVC carries appreciable morbidity, with pneumothorax being the most frequent mechanical complication. The SCV was the most commonly used approach at our institution. The majority of CVCs were performed by junior doctors and this was associated with a considerable complication rate.
Prevalence, management and outcome of traumatic diaphragm injuries managed by the Pietermaritzburg Metropolitan Trauma Service
Authors: D’Souza N , Clarke D , Laing G 
Published: May 2017

INTRODUCTION This audit of traumatic diaphram injury (TDI) from a busy South African trauma service reviews the spectrum of disease and highlights current approaches to these injuries. METHODS The Pietermaritzburg Metropolitan Trauma Service (PMTS) has maintained an Electronic Surgical Registry (ESR) and a Hybrid Electronic Medical Record (HEMR) system since January 1st 2012. RESULTS A total of 105 TDIs were identified and repaired during the study period. The mean patient age was 30 years (range 15-68 years - SD 9.7). The majority (92.4%) of patients were male (97/105). Penetrating trauma was the leading mechanism of injury (94%). 75 patients sustained a TDI from a stab wound, and the remaining 24 injuries resulted from gunshot wounds. Multiple associated injuries and high morbidity was seen with right diaphragm injury, blunt trauma, gunshot wounds and chronic diaphragmatic hernias. CONCLUSIONS TDI is a fairly uncommon injury with a local incidence of 1.6%. It presents in a spectrum from the obvious to the occult. Multiple associated injuries and high morbidity occur following blunt trauma or gunshot wounds, right diaphragm injury and chronic diaphragmatic hernias. Diagnostic laparoscopy offers a diagnostic and therapeutic tool to prevent progression of occult TDI to chronic diaphragmatic hernias.
EDITORIAL
Authors: Utama Mahendra P. 
Published: May 2017

JSCL edisi ini mengusung tema mengenai konflik dan integrasi sosial, dua realitas yang selalu mengiringi perjalanan sejarah masyarakat di mana pun baik masyarakat skala kecil maupun besar. Konflik dan integrasi juga menjadi isu yang selalu penting di Indonesia. Sejumlah studi yang telah disunting oleh Colombijn dan Lindblad (2002), Stokhof dan Djamal (2003), dan van Bemellen dan Raben (2011) memuat daftar panjang konflik di Indoneisa pada periode 1950-an hingga 1990-an. Studi-studi itu sekaligus menginspriasi kita untuk melihat kembali narasi besar tentang integrasi bangsa.
Stabreimende Wortpaare in den früheren Werken Hartmanns von Aue: Erec, Klage, Minnesang
Authors: Jeep John M. 
Published: May 2017

AbstractBuilding upon recent phraseological studies on Old High and Middle High German texts, the alliterating word pairs in the early works of Hartmann von Aue are catalogued and analyzed philologically, thus contributing to an emerging complete listing of the paired rhetorical expressions through the Early Middle High German period. The first extant courtly Arthurian romance, Hartmann'sErec,a shorter piece of his known asDiu Klage,and a handful of poems he composed are by all indications from the last decade of the twelfth century, despite later manuscript transmission. Each pair is listed, described in the context in which it appears, and compared with any extant pairs from earlier German works. What emerge are insights into the evolution of these expressions, in some cases through centuries. On the one hand, Hartmann employs alliterating expressions that date to the Old High German period, while on the other hand apparently creating new ones. As in findings in earlier texts, pairs recorded on multiple occasions are likely to have been used by other authors. Typical for medieval German texts – when compared to similar modern expressions – is the insight that there is a fair amount of variation concerning the sequence of the alliterating elements and/or the inclusion of morpho-syntactic modifiers such as pronouns, possessives, adjectives, or adverbs. Modern translations of Hartmann's works into German and English show just how varied these phrases can appear in translation. When known, later examples of the alliterating word-pairs are cited, albeit for obvious reasons only in an incomplete fashion. The long-term project is designed to continue to chart the emergence of the early German alliterating word-pairs chronologically.
Les chengyu du chinois : caractérisation de phrasèmes hors norme
Authors: Henry Kevin 
Published: May 2017

Abstract
Whereas Western scholars have been studying polylexical sequences in European languages for a long time, we cannot but recognise that the investigation into Chinese phrasemes, on the other hand, still needs further development: research on idioms is limited to compiling glossaries and adopts an approach more prescriptive than descriptive, while explanations in specialised dictionaries merely give paraphrase meanings, etymology and very few usage examples. Considering the multiplicity of viewpoints and the abundance of confusing terminology that have prevailed in Chinese phraseological studies, it appears crucial to make an assessment. In this article, after a brief review of the literature in China, we will set out on bringing a new light on one type of phrasemes that is generally considered as one of the most representative in Chinese language, namely sizige chengyu – which we will call “four-syllable idioms” or simply chengyu.
Biological, botanical and chemical alternatives for the control of blackberry (Rubus glaucus Benth.) diseases
Authors: Hincapié Echeverri Oscar Darío , Saldarriaga Cardona Alegría , Díaz Diez Cipriano 
Published: May 2017

In order to control the main diseases that affect blackberries (Rubus glaucus Benth.), a research in which 12 treatments to San Antonio ecotype plants originated in vitro was conducted. These treatments were: 1: Trichoderma harzianum+richoderma koningii (Tropical Fungus), 2: Trichoderma sp. (Bioprotection), 3: Trichoderma koningiopsis (Th003 Trichoderma), 4: Trichoderma asperellum (Th034 Trichoderma), 5: Trichoderma asperellum (T-30 Trichoderma), 6: Trichoderma asperellum (T-98 Trichoderma), 7:Burkholderia cepacia (Botrycid), 8: extract of Swinglea glutinosa (Ecoswin), 9: traditional farming treatments (Mancozeb, Propamocarb), 10: chemical products applications (Mancozeb, Mandipropamida, Carbendazim, Propamocar and Metalaxil+Mancozeb) alternated according to the impact of the disease, 11: chemical products applications alternated with organic products according to the suppliers recommendations and presence of the diseases, 12: absolute control, no treatment was applied to the plants. The applications were carried out every 15 days, each plant was an experimental unit and each treatment was made of five experimental units. 12 treatments were made through a RCBD (randomized complete block design) with three repetitions for a total of 15 experimental units per treatment. The assessments were performed every 8 days, and the variables were: number of healthy and sick fruits/treatment, costs/treatment and gross profit. A variance analysis and a Tukey test 5% were made. The best treatments were T11 (rotation of chemicals with biological products), T10 (rotation of chemical products according to the impact of the disease) and T3 (T. koningiopsis); considering the obtained performance/treatment, treatment cost and profit.
Organic acids to eliminate interference by phosphorus in the analysis of silicon by molecular absorption
Authors: Combatt Caballero Enrique M , Palacio Badel Daniel , Palencia Luna Manuel 
Published: May 2017

One of the problems for quantifying the amount of silicon available by molecular absorption is the elimination of chemical interference caused by available phosphorus. The aim of this work was to evaluate different organic acids in eliminating the interference caused by phosphorus in the quantification of available silicon by molecular absorption. The experiments were conducted in the Soil laboratory of the College of Agricultural Sciences at the Universidad de Córdoba, Colombia. For this work, different acids such as tartaric, citric, oxalic and malic were evaluated at two concentrations (0.8 and 1.33 mol L-1). Solutions containing silicon (1 mg L-1) and six concentrations of phosphorus were prepared (0.0, 0.2, 0.4, 0.6, 0.8 and 1.0 mg L-1). The quantification of silicon was conducted by molecular absorption spectrophotometry using a Perkin Elmer Lambda XLS + at 660 nm. The results were subjected to the LSD tests and contrasts using the R software (Development Core Team, version 3.2.2).The results indicated that the oxalic, citric and malic acids at both concentrations produced lower overestimation of silicon in the presence of the P concentrations 0.6, 0.8 and 1.0 mgL-1 than the tartaric acid, which is commonly used as a reference to remove the P interference.