bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Service” in Luxury Retailing in the Twenty‐First Century: An Exploratory Look at the Pleasure Boating Sector
Authors: Amatulli Cesare , Nataraajan Rajan , Capestro Mauro , Carvignese Marco , Guido Gianluigi 
Published: April 2017

ABSTRACTThis study explores the most effective retailing strategies with which luxury retailers can achieve a competitive advantage. The central role of services in enhancing the consumption experience in the luxury segment has been analyzed considering the pleasure boating sector, with a focus on the role that the dealer may have, both in the integration of different services and in the development of a durable competitive advantage. A qualitative study has been carried out through semistructured, in‐depth, one‐to‐one interviews with representatives of companies that deal with the pleasure boating sector. The results show that in the luxury pleasure boating sector, the introduction of a better‐defined retail strategy focused on services and its integration within the entire distribution channel may be crucial but also difficult to achieve in contexts that lack a marketing orientation. The contribution to extant literature on service in the pleasure boating sector and in luxury retailing in general is outlined. The managerial implications for practitioners in the pleasure boating sector are also discussed.
Reconstruction of late esophagus perforation after anterior cervical spine fusion with an adipofascial anterolateral thigh free flap: A case report
Authors: Coelho Ruben , Ekberg Tomas , Svensson Malin , Mani Maria , Rodriguez‐Lorenzo Andres 
Published: April 2017

Reconstruction of late esophageal perforation usually requires flap surgery to achieve wound healing. However, restoring the continuity between the digestive tract and retropharyngeal space to allow for normal swallowing remains a technical challenge. In this report, we describe the use of a thin and pliable free adipofascial anterolateral thigh (ALT) flap in a 47‐year‐old tetraplegic man with a history of C5–C6 fracture presented with a large posterior esophagus wall perforation allowing an easier flap insetting for a successful wound closure. The postoperative course was uneventful and mucosalization of the flap was confirmed by esophagoscopy 4 weeks postsurgery. The patient tolerated normal diet and maintained normal swallowing during a follow‐up of 3 years postoperatively. The adipofascial ALT flap may provide easier insetting due to the thin and pliable layer of adipofascial tissue for reconstructing large defects of the posterior wall of the esophagus by filling the retroesophageal space.
Oligosynaptic inhibition of group Ia afferents from brachioradialis to triceps brachii motor neurons in humans
Authors: Sato Toshiaki , Nito Mitsuhiro , Suzuki Katsuhiko , Fujii Hiromi , Hashizume Wataru , Miyasaka Takuji , Shindo Masaomi , Naito Akira 
Published: April 2017

ABSTRACTIntroduction: This study examines effects of low‐threshold afferents from the brachioradialis (BR) on excitability of triceps brachii (TB) motor neurons in humans. Methods: We evaluated the effects using a post stimulus time histogram (PSTH) and electromyogram averaging (EMG‐A) methods in 13 healthy human participants. Electrical conditioning stimulation to the radial nerve branch innervating BR with the intensity below the motor threshold was delivered. Results: In the PSTH study, the stimulation produced a trough (inhibition) in 36/69 TB motor units for all the participants. A cutaneous stimulation never provoked such inhibition. The central latency of the inhibition was 1.5 ± 0.5 ms longer than that of the homonymous facilitation. In the EMG‐A study, the stimulation produced inhibition in EMG‐A of TB in all participants. The inhibition diminished with a tonic vibration stimulation to BR. Discussion: These findings suggest that oligosynaptic inhibition mediated by group Ia afferents from BR to TB exists in humans. Muscle Nerve 57: 122–128, 2018
A cost analysis of implementing a behavioral weight loss intervention in community mental health settings: Results from the ACHIEVE trial
Authors: Janssen Ellen M. , Jerome Gerald J. , Dalcin Arlene T. , Gennusa Joseph V. , Goldsholl Stacy , Frick Kevin D. , Wang Nae‐Yuh , Appel Lawrence J. , Daumit Gail L. 
Published: April 2017

ObjectiveIn the ACHIEVE randomized controlled trial, an 18‐month behavioral intervention accomplished weight loss in persons with serious mental illness who attended community psychiatric rehabilitation programs. This analysis estimates costs for delivering the intervention during the study. It also estimates expected costs to implement the intervention more widely in a range of community mental health programs.MethodsUsing empirical data, costs were calculated from the perspective of a community psychiatric rehabilitation program delivering the intervention. Personnel and travel costs were calculated using time sheet data. Rent and supply costs were calculated using rent per square foot and intervention records. A univariate sensitivity analysis and an expert‐informed sensitivity analysis were conducted.ResultsWith 144 participants receiving the intervention and a mean weight loss of 3.4 kg, costs of $95 per participant per month and $501 per kilogram lost in the trial were calculated. In univariate sensitivity analysis, costs ranged from $402 to $725 per kilogram lost. Through expert‐informed sensitivity analysis, it was estimated that rehabilitation programs could implement the intervention for $68 to $85 per client per month.ConclusionsCosts of implementing the ACHIEVE intervention were in the range of other intensive behavioral weight loss interventions. Wider implementation of efficacious lifestyle interventions in community mental health settings will require adequate funding mechanisms.
Sample Conditions Under Which Bias in IV Estimates can be Signed
Authors: Jung Haeil , Pirog Maureen A. 
Published: April 2017

AbstractThe relative size of the treated and untreated groups, or the T/UT ratio, in an analysis sample often diverges from the T/UT ratio in the population (or original sample) because of choice‐based sampling and missing values. While divergences of the sample from the population T/UT ratio do not generate bias for many estimators, instrumental variable (IV) estimates might be biased by such divergences even when (1) the IV is analytically valid for the population and (2) the sample‐treated and ‐untreated groups are representative of the population‐treated and ‐untreated groups, respectively. We survey published empirical manuscripts to show that this issue is prevalent across various fields. We also prove that the bias in IV estimates, generated by divergences of the sample from population T/UT ratio, is a monotonic function of the difference between the sample and population T/UT ratios when the above conditions (1 and 2) are met. Based on our findings, we suggest possible solutions and provide advice on how to interpret the bias in IV estimates even when the true T/UT ratio is not known.
Effects of expanding the look‐back period to all available data in the assessment of covariates
Authors: Nakasian Sonja S. , Rassen Jeremy A. , Franklin Jessica M. 
Published: April 2017

AbstractBackgroundA fixed baseline period has been a common covariate assessment approach in pharmacoepidemiological studies from claims but may lead to high levels of covariate misclassification. Simulation studies have recommended expanding the look‐back approach to all available data (AAD) for binary indicators of diagnoses, procedures, and medications, but there have been few real data analyses using this approach.ObjectiveThe objective of the study is to explore the impact on treatment effect estimates and covariate prevalence of expanding the look‐back period within five validated studies in the Aetion system, a rapid cycle analytics platform.MethodsWe reran the five studies and assessed covariates using (i) a fixed window approach (usually 180 days before treatment initiation), (ii) AAD prior to treatment initiation, and (iii) AAD with a categorized by recency approach, where the most recent occurrence of a covariate was labeled as recent (occurring within the fixed window) or past (before the start of the fixed window). For each covariate assessment approach, we adjusted for covariates via propensity score matching.ResultsAll studies had at least one covariate that had an increase in prevalence of 15% or higher from the fixed window to the AAD approach. However, there was little change in treatment effect estimates resulting from differing covariate assessment approaches. For example, in a study of acute coronary syndrome in high‐intensity versus low‐intensity statin users, the estimated hazard ratio from the fixed window approach was 1.11 (95% confidence interval 0.98, 1.25) versus 1.21 (1.07, 1.37) when using AAD and 1.19 (1.05, 1.35) using categorized by recency.ConclusionExpanding the baseline period to AAD improved covariate sensitivity by capturing data that would otherwise be missed yet did not meaningfully change the overall treatment effect estimates compared with the fixed window approach. Copyright © 2017 John Wiley & Sons, Ltd.
The neurobiology of social deficits in female patients with borderline personality disorder: The importance of oxytocin
Authors: Bomann Anne Cathrine , Jørgensen Martin Balslev , Bo Sune , Nielsen Marianne , Gede Lene Bjerring , Elfving Betina , Simonsen Erik 
Published: April 2017

AbstractBackgroundSocial deficits and emotional dysregulation have been suggested as explanations for the relational difficulties experienced by patients with borderline personality disorder (BPD). The neuropeptide oxytocin (OXT) is a possible neurobiological underpinning of these adversities, and this study examines possible correlations between BPD symptomatology and serum OXT.MethodsThirty‐eight female participants (BPD group n = 18, matched control group n = 20) with a mean age of 29.5 years (standard deviation 9.2) were assessed for personality disorders, general psychopathology, childhood trauma and perceived stress. OXT was measured in serum samples.ResultsWe found no significant difference between patient and control group in terms of OXT levels. However, post hoc analysis showed a relationship in the patient group between civil status and OXT (p < 0.05), indicating higher levels of OXT for patients in a romantic relationship.DiscussionThe idea of OXT as a pro‐social love hormone is perhaps too simplistic, and factors like attachment style, exposure to trauma and psychiatric disorders must be considered in order to understand its diverse functions.ConclusionsContrary to our expectations, we did not find lower serum OXT levels in the BPD group. However, BPD patients in a romantic relationship had higher levels of serum OXT than single BPD patients. Copyright © 2017 John Wiley & Sons, Ltd.
Informalisation in Low‐wage Labour Markets: a Case Study of the UK Food Industry
Authors: Scott Sam 
Published: April 2017

AbstractInformalisation is a process that involves the lowering of the floor for pay and working conditions, sometimes legally and sometimes illegally, and it may occur in both formal and informal labour market settings. This paper examines what informalisation looks like in practice in the UK context. Drawing on the experiences of 62 low‐wage migrant workers, employed in the UK food industry, the paper identifies five facets of ‘informalisation’, namely, job insecurity, work intensification, worker expendability, worker subordination, and employment intermediation. The identification of these five facets of informalisation is important in its own right. In addition, the UK case study also serves to emphasise the fact that the degradation of work is not something that is simply confined to the margins but is evident in the mainstream (beyond irregular workers and beyond the informal economy). Copyright © 2017 John Wiley & Sons, Ltd.
Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in magnetic resonance imaging: a theoretical review
Authors: Vuong Quoc Lam , Gillis Pierre , Roch Alain , Gossuin Yves 
Published: April 2017

Superparamagnetic nanoparticles are used as contrast agents in magnetic resonance imaging and allow, for example, the detection of tumors or the tracking of stem cells in vivo. By producing magnetic inhomogeneities, they influence the nuclear magnetic relaxation times, which results in a darkening, on the image, of the region containing these particles. A great number of studies have been devoted to their magnetic properties, to their synthesis and to their influence on nuclear magnetic relaxation. The theoretical and fundamental understanding of the behavior of these particles is a necessary step in predicting their efficiency as contrast agents, or to be able to experimentally obtain some of their properties from a nuclear magnetic resonance measurement. Many relaxation models have been published, and choosing one of them is not always easy, many parameters and conditions have to be taken into account. Relaxation induced by superparamagnetic particles is generally attributed to an outersphere relaxation mechanism. Each model can only be used under specific conditions (motional averaging regime, static regime, high magnetic field, etc.) or for a particular sequence (Carr‐Purcell‐Meiboom‐Gill, spin echo, free‐induction decay, nuclear magnetic relaxation dispersion profile, etc.). The parameters included in the equations must be carefully interpreted. In some more complex conditions, simulations are necessary to be able to predict the relaxation rates. A good agreement is usually observed between the theoretical predictions and the experimental results, although some data still cannot be fully understood, such as the dependence of the transverse relaxation on the magnetic field. WIREs Nanomed Nanobiotechnol 2017, 9:e1468. doi: 10.1002/wnan.1468This article is categorized under:

Diagnostic Tools > Diagnostic Nanodevices
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
First Application of Newly Developed FT‐NIR Spectroscopic Methodology to Predict Authenticity of Extra Virgin Olive Oil Retail Products in the USA
Authors: Mossoba Magdi M. , Azizian Hormoz , Fardin‐Kia Ali Reza , Karunathilaka Sanjeewa R. , Kramer John K. G. 
Published: April 2017

AbstractEconomically motivated adulteration (EMA) of extra virgin olive oils (EVOO) has been a worldwide problem and a concern for government regulators for a long time. The US Food and Drug Administration (FDA) is mandated to protect the US public against intentional adulteration of foods and has jurisdiction over deceptive label declarations. To detect EMA of olive oil and address food safety vulnerabilities, we used a previously developed rapid screening methodology to authenticate EVOO. For the first time, a recently developed FT‐NIR spectroscopic methodology in conjunction with partial least squares analysis was applied to commercial products labeled EVOO purchased in College Park, MD, USA to rapidly predict whether they are authentic, potentially mixed with refined olive oil (RO) or other vegetable oil(s), or are of lower quality. Of the 88 commercial products labeled EVOO that were assessed according to published specified ranges, 33 (37.5%) satisfied the three published FT‐NIR requirements identified for authentic EVOO products which included the purity test. This test was based on limits established for the contents of three potential adulterants, oils high in linoleic acid (OH‐LNA), oils high in oleic acid (OH‐OLA), palm olein (PO), and/or RO. The remaining 55 samples (62.5%) did not meet one or more of the criteria established for authentic EVOO. The breakdown of the 55 products was EVOO potentially mixed with OH‐LNA (25.5%), OH‐OLA (10.9%), PO (5.4%), RO (25.5%), or a combination of any of these four (32.7%). If assessments had been based strictly on whether the fatty acid composition was within the established ranges set by the International Olive Council (IOC), less than 10% would have been identified as non‐EVOO. These findings are significant not only because they were consistent with previously published data based on the results of two sensory panels that were accredited by IOC but more importantly each measurement/analysis was accomplished in less than 5 min.
Back to School: Racial and Gender Differences in Adults’ Participation in Formal Schooling, 1978–2013
Authors: Denice Patrick 
Published: April 2017

AbstractTrends and gaps in educational attainment by race and gender have received much attention in recent years, but reports of these trends have generally focused on traditional-age college students. Little is known about whether and how enrollment in formal schooling among older adults (between 29 and 61 years old) has changed over time. In this article, I draw on Current Population Survey data from 1978 to 2013 to provide the most comprehensive analysis of trends in adults’ formal school enrollment by demographic group to date. Results indicate that adult black women in particular have seen relatively high growth rates in their enrollment. Black women were 85 % more likely to enroll in 2011 and 46 % more likely in 2013 than they were in 1978. Their growing advantage relative to other racial-gender groups owes largely to their increasing educational attainment rates overall, given the relationship between prior schooling and enrollment later in life. Taken together, this article’s findings suggest that adult enrollment is at once equalizing and disequalizing. On the one hand, it has the potential to narrow the gaps between those with some college experience and those with a four-year degree. On the other hand, patterns of adults’ participation in formal education are widening educational gaps between those with and without traditional-age college experience.
Learning at large conferences: from the ‘sage on the stage’ to contemporary models of learning
Authors: Torre Dario , Manca Annalisa , Durning Steven , Janczukowicz Janusz , Taylor David , Cleland Jennifer 
Published: April 2017

Aim To explore and evaluate the affordances of a flipped classroom model applied to a research paper session within the professional development opportunity of a large conference setting.
Method Authors were invited to present their research papers in a flipped classroom presentation format at two large, multi-national conferences. Before the session, authors and moderators met online to clarify features of the session, and preparation of the material. The research material was then posted online before the conference, to allow access by meeting attendees. During the sessions, moderators encouraged the audience to actively participate. An evaluation form was collected from the audience at the end of each session.
Results Participants found the session valuable, and appreciated the opportunity to engage in a meaningful dialogue with colleagues. However, the majority of the audience did not access the materials in advance. Lack of time, or technology-related issues were mentioned as potential challenges to such format.
Conclusion In the context of a large conference, a ‘flipped session’ format can facilitate active learning and a participatory culture of inquiry. However, to change the nature of how individuals learn collaboratively at large conferences means a change in the culture of continuous professional learning.
Study of intra–inter species protein–protein interactions for potential drug targets identification and subsequent drug design for Escherichia coli O104:H4 C277-11
Authors: Mondal Shakhinur Islam , Mahmud Zabed , Elahi Montasir , Akter Arzuba , Jewel Nurnabi Azad , Muzahidul Islam Md. , Ferdous Sabiha , Kikuchi Taisei 
Published: April 2017

AbstractProtein–protein interaction (PPI) and host–pathogen interactions (HPI) proteomic analysis has been successfully practiced for potential drug target identification in pathogenic infections. In this research, we attempted to identify new drug target based on PPI and HPI computation approaches and subsequently design new drug against devastating enterohemorrhagicEscherichia coliO104:H4 C277-11 (Broad), which causes life-threatening food borne disease outbreak in Germany and other countries in Europe in 2011. Our systematic in silico analysis on PPI and HPI ofE. coliO104:H4 was able to identify bacteriald-galactose-binding periplasmic and UDP-N-acetylglucosamine 1-carboxyvinyltransferase as attractive candidates for new drug targets. Furthermore, computational three-dimensional structure modeling and subsequent molecular docking finally proposed [3-(5-Amino-7-Hydroxy-[1,2,3]Triazolo[4,5-d]Pyrimidin-2-Yl)-N-(3,5-Dichlorobenzyl)-Benzamide)] and (6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one) as promising candidate drugs for further evaluation and development forE. coliO104:H4 mediated diseases. Identification of new drug target would be of great utility for humanity as the demand for designing new drugs to fight infections is increasing due to the developing resistance and side effects of current treatments. This research provided the basis for computer aided drug design which might be useful for new drug target identification and subsequent drug design for other infectious organisms.
Factors associated with response after deep transcranial magnetic stimulation in a real-world clinical setting: Results from the first 40 cases of treatment-resistant depression
Authors: Feffer K. , Lapidus K.A.B. , Braw Y. , Bloch Y. , Kron S. , Netzer R. , Nitzan U. 
Published: April 2017

AbstractBackground:Deep transcranial magnetic stimulation (dTMS) has been sanctioned by the United States Food and Drug Administration for treatment-resistant depression. In a retrospective cohort study, we evaluated response and effectiveness of dTMS in real-world practice, as an add-on treatment for resistant depression.Methods:Forty adult outpatients suffering from depression, all taking psychiatric medications, underwent 20 dTMS treatments over a 4–6 week period. At baseline (T0), visit 10 (T1), and visit 20 (T2), the Clinical Global Impression-Severity (CGI-S) scale was administered, and the Clinical Global Impression Improvement (CGI-I) scale was completed at T1 and T2; the Hamilton Depression Rating Scale (HDRS-21) was administrated at T0 and T2 only. The patients also completed the Quick Inventory of Depressive Symptoms–Self-Report (QIDS-SR) at T0, T1, and T2.Results:Depressive symptoms (HDRS-21 total score) decreased significantly following treatment. The HDRS total score decreased from an average of 21.22 (± 6.09) at T0, to 13.95 (± 7.24) at T2. Correspondingly, at T2, 32.5% were responders to the treatment and 20% were in remission, based on the HDRS-21. Treatment was well tolerated, with a discontinuation rate of 7.5%. While depressive symptoms at baseline did not predict remission/response at T2, higher HDRS scores at T0 were associated with a larger decrease in depressive symptoms during the study.Conclusions:Significant antidepressant effects were seen following 20 dTMS treatments, given as augmentation to ongoing medications in treatment-resistant depression. The findings suggest that among patients with TRD, the severity of the depressive episode (and not necessarily the number of failed antidepressant medication trials) is associated with a positive therapeutic effect of dTMS. Hence, the initial severity of the depressive episode may guide clinicians in referring patients for dTMS.