bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creaciones divinas y creaciones humanas: la condición ontológica del ser humano y de los enseres rituales lacandones.
Authors: Balsanelli Alice 
Published: September 2024

El artículo propone una comparación entre el proceso de creación de los seres humanos, narrado en el mito ontogenético lacandón, y la elaboración de los enseres rituales de arcilla y hule. Los lacandones consideran a estos objetos como sujetos, y les otorgan condición de persona (winik, en lengua maya). Lo anterior permite reflexionar sobre las nociones ontológicas del grupo estudiado, aclarando cuál es la concepción de persona en el pensamiento local. Para tal efecto, se ofrece un estudio comparativo, que toma en cuenta datos etnográficos procedentes de otros grupos mayas contemporáneos, así como trabajos inherentes a los mayas prehispánicos. Se argumenta que la condición de persona no depende de la materia prima de la cual se constituyen los cuerpos, ni de la dotación anímica, sino de un proceso de creación que conlleva el establecimiento de una relación entre un Creador y el sujeto creado. Asimismo, se ofrece una nueva interpretación de los enseres rituales, ya no estudiados desde un punto de vista simbólico, sino ontológico, de acuerdo con las ideas expresadas por los informantes.
TRACING THE HERITAGE AND CIVILIZATION OF AUSTRONESIAN SEAFARERS ACROSS WATERS, SEAS, AND OCEANS IN THE ARCHIPELAGO OF SOUTHEAST ASIA
Authors: Ali Ismail , Abdullah Mohd Firdaus 
Published: September 2024

The waters, seas and oceans have traditionally been a source of inspiration for the search for the truth. It also manages to negate the human worldview that associates it with various elements of myth and superstition. The waters, sea and oceans are also a place with the advantage of consolidating ties between countries, forming a united, mutual understanding and unity spirit and generating mutual wealth. It is an invaluable, irreplaceable and modified property. Historiography in Southeast Asia saw a close relationship between people named "humans‵‵ in the South China Sea, Sulu Sea, Sulawesi Sea, Flores Sea, Java Sea, Banda Sea and so on. History has shown how they have fought hard through various waves and storms in the seas and oceans simply to ensure that the next generation holds the souls of the sailors. It has made the region a centre of superior civilization as well as a model for the centers of other world civilizations. Therefore, this writing aims to reassess the history of the existence of the Austronesian seafarers from the perspective of the history in Southeast Asia themselves. The results of this study have opened the enactment of whether it is true that the origin of this Austronesian seafarer’s tribe originated in Taiwan as stated in the theory of migration and linguistics. In other words, the Austronesian seafarer today come from Southeast Asia itself and have migrated out to expand their civilizations in regions of Oceania such as Polynesia, Melanesia, and Micronesia all the way to Taiwan up to Madagascar. There is no easy answer to this matter and need to study from various disciplines and space to find strong evidence of the Austronesian seafarers.
The Protective Role of Vitamin E on the Liver, Kidney, and Male Reproductive Functions of Paracetamol Overdose in Male Rabbits
Authors: Hasan Shireen , Riyadh Abdulah Ali  , Alaa Alnaser  
Published: September 2024

Pharmaceutical harm may result from both planned effects and pharmaceutical errors. Although paracetamol is often used as an antipyretic and painkiller, an excessive amount of it may be toxic to the liver and create free radicals that are harmful to human health. Thirty adult male rabbits were divided into three groups. Group I was orally administered normal saline (control). Group II (Paracetamol toxic dose) was orally administered paracetamol (1500mg /kg b.w ) dissolved in normal saline. Group III (Paracetamol & vitE) (1500;400)mg/kg b.w), respectively. All group doses were given for three weeks daily. The findings revealed that a toxic dose of paracetamol increased oxidative stress (MDA), liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AS.T), alkaline phosphatase (ALP), the levels of serum creatinine (Cr), urea, and blood urea nitrogen (BUN), and decreased testosterone hormone. Additionally, the findings revealed a notable improvement in the liver and kidney functions. This study demonstrates that paracetamol in overdose elevated oxidative stress and hepatotoxicity, and nephrotoxicity reduced testosterone hor, but on the other hand, vitamin E had a protective effect of eliminating this disruptor.
Cardiovascular autonomic neuropathy and the risk of diabetic kidney disease
Authors: Cho Injeong , Lim Seohyun , Kwon Minjae , Chung Seung Min , Moon Jun Sung , Yoon Ji Sung , Won Kyu Chang 
Published: September 2024

BackgroundCardiovascular autonomic neuropathy (CAN) is known to affect patients with diabetes mellitus (DM) and cause adverse renal outcomes. We aimed to analyze the association between CAN and diabetic kidney disease (DKD).MethodWe enrolled 254 DM patients (mean age, 56.7 ± 15.2 years; male: female ratio, 1.17:1) with 19 (7.5%) type 1 DM patients and 235 (92.5%) type 2 DM patients. All patients had undergone cardiovascular autonomic function tests between January 2019 and December 2021 in a tertiary hospital in Korea. Cardiovascular autonomic neuropathy was categorized as normal, early, or definite after measuring three heart rate variability parameters. Diabetic kidney disease refers to a persistently elevated urinary albumin-creatinine ratio (uACR ≥30 mg/g) or reduced estimated glomerular filtration rate (eGFR &lt;60 mL/min/1.73 m2). Logistic and Cox regression analyses were performed.ResultsPatients with elevated uACR (n=107) and reduced eGFR (n=32) had a higher rate of definite CAN. After adjusting for covariates, definite CAN was associated with elevated uACR (OR=2.4, 95% CI 1.07-5.36) but not with reduced eGFR (OR=3.43, 95% CI 0.62-18.90). A total of 94 patients repeated uACR measurements within 2 years (mean follow-up, 586.3 ± 116.8 days). Both definite and early CAN were independent risk factors for elevated uACR (HR=8.61 and 8.35, respectively; both p&lt;0.05). In addition, high-density lipoprotein cholesterol, ACE inhibitors/angiotensin receptor blockers and glucagon-like peptide-1 receptor agonists were independent protective factors for elevated uACR (HR=0.96, 0.25, and 0.07, respectively; all p&lt;0.05).ConclusionCardiovascular autonomic neuropathy is a potential indicator of DKD. Comprehensive management of DKD in the early stages of CAN may prevent microalbuminuria.
Undernutrition and associated factors among lactating mothers in Chiro district, eastern Ethiopia: a community-based cross-sectional study
Authors: Fekadu Mesfin , Egata Gudina , Mengestie Bezatu , Adem Hassen Abdi , Usso Ahmedin Aliyi 
Published: September 2024

BackgroundMaternal undernutrition during lactation is a worldwide public health problem. It causes impaired cognitive ability, poor productivity, irreversible loss, and intergenerational malnutrition, which has harmful effects on the next generation. Overall, there is little information on undernutrition and risk factors among lactating mothers, especially in resource-poor settings, including Ethiopia. This study assessed undernutrition and associated factors among lactating mothers in rural Chiro district, eastern Ethiopia.MethodA community-based cross-sectional study was conducted among 629 lactating mothers in the Chiro district from July 2–30, 2019. Data were collected from participants using pretested, structured questionnaires and anthropometric measurements. Data were entered using EpiData version 3.1 and analyzed using SPSS version 27. Multivariable logistic regression analyses were used to identify factors associated with undernutrition.ResultsUndernutrition among lactating mothers was 26.9% (95% CI: 23.2%, 30.2%). Female-headed household (AOR = 0.34, 95% CI:0.13, 0.94), medium (AOR = 0.58, 95% CI: 0.38, 0.95) and rich (AOR = 0.30, 95% CI: 0.18, 0.51) wealth quintiles, lack of dietary advice (AOR = 1.62, 95% CI: 1.10, 2.39), chewing khat (AOR = 1.82, 95% CI: 1.23, 2.70), low dietary diversity (AOR = 3.10, 95% CI: 1.82, 5.29), and household food insecurity (AOR = 3.67, 95% CI:1.47, 9.20) were factors significantly associated with undernutrition.ConclusionsAround one in every four lactating mothers in rural eastern Ethiopia had undernutrition. Poor wealth, lack of dietary feeding advice, substance use disorder, low minimum dietary diversity, and household food insecurity were factors significantly associated with the undernutrition of lactating mothers. Thus, focusing on implementing existing strategies/programs for effective nutritional interventions and poverty alleviation that enhance food security status would be essential to improving the nutritional status of lactating mothers and children.
Investigating the interplay between segregation and integration in developing cortical assemblies
Authors: Barabino Valerio , Donati della Lunga Ilaria , Callegari Francesca , Cerutti Letizia , Poggio Fabio , Tedesco Mariateresa , Massobrio Paolo , Brofiga Martina 
Published: September 2024

IntroductionThe human brain is an intricate structure composed of interconnected modular networks, whose organization is known to balance the principles of segregation and integration, enabling rapid information exchange and the generation of coherent brain states. Segregation involves the specialization of brain regions for specific tasks, while integration facilitates communication among these regions, allowing for efficient information flow. Several factors influence this balance, including maturation, aging, and the insurgence of neurological disorders like epilepsy, stroke, or cancer. To gain insights into information processing and connectivity recovery, we devised a controllable in vitro model to mimic and investigate the effects of different segregation and integration ratios over time.MethodsWe designed a cross-shaped polymeric mask to initially establish four independent sub-populations of cortical neurons and analyzed how the timing of its removal affected network development. We evaluated the morphological and functional features of the networks from 11 to 18 days in vitro (DIVs) with immunofluorescence techniques and micro-electrode arrays (MEAs).ResultsThe removal of the mask at different developmental stages of the network lead to strong variations in the degree of intercommunication among the four assemblies (altering the segregation/integration balance), impacting firing and bursting parameters. Early removal (after 5 DIVs) resulted in networks with a level of integration similar to homogeneous controls (without physical constraints). In contrast, late removal (after 15 DIVs) hindered the formation of strong inter-compartment connectivity, leading to more clustered and segregated assemblies.DiscussionA critical balance between segregation and integration was observed when the mask was removed at DIV 10, allowing for the formation of a strong connectivity among the still-separated compartments, thus demonstrating the existence of a time window in network development in which it is possible to achieve a balance between segregation and integration.
Research hotspots and trends of epigenetic therapy in oncology: a bibliometric analysis from 2004 to 2023
Authors: Li Sisi , Liang Xinrui , Shao Qing , Wang Guanwen , Huang Yuxin , Wen Ping , Jiang Dongping , Zeng Xiaohua 
Published: September 2024

BackgroundEpigenetics denotes heritable alterations in gene expression patterns independent of changes in DNA sequence. Epigenetic therapy seeks to reprogram malignant cells to a normal phenotype and has been extensively investigated in oncology. This study conducts a bibliometric analysis of epigenetic therapy in cancer, providing a comprehensive overview of current research, identifying trends, and highlighting key areas of investigation.MethodsPublications concerning epigenetic inhibitors in cancer spanning 2004 to 2023 were retrieved from the Web of Science Core Collection (WoSCC). Co-occurrence analysis using VOSviewer assessed current status and focal points. Evolutionary trends and bursts in the knowledge domain were analyzed using CiteSpace. Bibliometrix facilitated topic evolution and revealed trends in keywords. National, institutional, and author affiliations and collaborations were also examined.ResultsA total of 2,153 articles and reviews on epigenetic therapy in oncology were identified, demonstrating a consistent upward trend over time. The United States (745 papers), University of Texas MD Anderson Cancer Center (57 papers), and Stephen B. Baylin (27 papers) emerged as the most productive country, institution, and author, respectively. Keyword co-occurrence analysis identified five primary clusters: tumor, DNA methylation, epigenetic therapy, expression, and immunotherapy. In the past 5 years, newly emerging themes with increased centrality and density include “drug resistance,” “immunotherapy,” and “combination therapy.” The most cited publication reviewed current understanding of potential causes of epigenetic diseases and proposed future therapeutic strategies.ConclusionIn the past two decades, the importance of epigenetic therapy in cancer research has become increasingly prominent. The United States occupies a key position in this field, while China, despite having published a large number of related papers, still has relatively limited influence. Current research focuses on the “combination therapy” of epigenetic drugs. Future studies should further explore the sequencing and scheduling of combination therapies, optimize trial designs and dosing regimens to improve clinical efficacy.
Effects of video-guided active breaks with curricular content on mental health and classroom climate in chilean schoolchildren aged 6 to 10: study protocol for a multicentre randomized controlled trial
Authors: Zapata-Lamana Rafael , Robles-Campos Alejandra , Reyes-Molina Daniel , Rojas-Bravo Jorge , Salcedo Lagos Pedro , Chávez-Castillo Yasna , Gajardo-Aguayo Jorge , Villalobos Jacqueline Valdebenito , Arias Ana María , Sanhueza-Campos Cristian , Ibarra Mora Jessica , Reyes-Amigo Tomás , Cristi-Montero Carlos , Sánchez-Oliva David , Ruiz-Hermosa Abel , Sánchez-López Mairena , Poblete-Valderrama Felipe , Celis-Morales Carlos , Martorell Miquel , Carrasco-Marín Fernanda , Albornoz-Guerrero Javier , Parra-Rizo María Antonia , Cigarroa Igor 
Published: September 2024

BackgroundThe incidence of mental health issues in children is increasing worldwide. In Chile, a recent surge in reports of deteriorating mental health among school populations and an increase in complaints related to poor school climate have been observed. Physical activity, specifically active breaks in the classroom, has shown positive effects on children’s health. However, evidence regarding its impact on mental health and school climate in children is limited.ObjectiveThis work outlines the design, measurements, intervention program, and potential efficacy of the “Active Classes + School Climate and Mental Health” project. This project will assess a 12-week program of active breaks through guided videos with curricular content in the school classroom, and its effects on mental health and school climate as its primary indicators. Additionally, it will measure physical activity, physical fitness, motor competence, and academic performance in students aged 6–10 years in the Biobío province, Chile, as secondary indicators. Methodology: A multicenter randomized controlled trial involving 823 students from 1st to 4th grade (6–10 years old), six schools (three intervention and three control) will be conducted in the Biobío region, Chile. Participants belonging to the intervention group will implement video-guided active breaks through the “Active Classes” web platform, featuring curricular content, lasting 5–10 min and of moderate to vigorous intensity physical activity, twice a day, Monday to Friday, over a span of 12 weeks. Expected Results/Discussion: To our knowledge, this will be the first study in Chile to evaluate the effects of incorporating video-guided active breaks with curricular content on mental health variables and school climate in schoolchildren. Thus, this study contributes to the scarce evidence on the effects of video-guided active breaks on mental health variables and school climate in schoolchildren worldwide. Additionally, it will provide crucial information about active teaching methodologies that have the potential to positively contribute to the wellbeing of students, thus addressing the problems of mental health and climate in Chilean schools. ClinicalTrials.gov ID NCT06423404.
Online interpersonal trust and online altruistic behavior in college students: the chain mediating role of moral identity and online social support
Authors: Sun Daokai , Lin Yingying , Liao Chuanjing , Pan Lili 
Published: September 2024

BackgroundThe prevalence of online altruistic behaviors among the college students has attracted widespread attention. However, the factors influencing this are still unclear. The objective of this study was to explore the relationship and mechanism of online interpersonal trust, moral identity, online social support and online altruistic behavior among college students.MethodsThe survey was conducted among 986 Chinese college students using the Interpersonal Trust Scale for the Internet, Moral Identity Scale, The Internet Social Support Questionnaire for College Students and The Internet Altruistic Behavior Questionnaire for College Students.ResultsMoral identity, online social support, online interpersonal trust and online altruistic behavior were significantly positively correlated (r = 0.09–0.39, p &lt; 0.01). Online social support plays a partial mediating role in the relation between online interpersonal trust and online altruistic behavior, accounting for 33.76% of the total effect, while moral identity and online social support play a chain mediating role in the relation between online interpersonal trust and online altruistic behavior, accounting for 2.23% of the total effect.ConclusionOnline interpersonal trust not only directly affects college students’ online altruistic behavior, but also indirectly influences it through moral identity and online social support.
State of the maternal healthcare continuum in Guinea, awaiting the next Demographic and Health Survey: the case of the five communes of Conakry in 2022
Authors: Leno Niouma Nestor , Leno Daniel William Athanase , Sow Abdoulaye , Kambadouno Gaston , Camara Alioune , Mayaka Serge , Delamou Alexandre 
Published: September 2024

BackgroundThe continuum of maternal health care ensures consistency in the delivery of care from pregnancy to the postnatal period. It recommends a minimum of 4 antenatal visits, skilled birth attendance, and 42 days of postnatal care. This approach helps reduce maternal deaths. The aim of this study was to estimate the proportion of women who had completed the different stages of the continuum of maternal health care (four antenatal visits, given birth under the care of qualified personnel, and received postnatal care within 42 days of delivery).MethodsThis was a cross-sectional analytical study conducted in the five communes of Conakry, using a two-stage cluster sampling for data collection. Results were described using medians and percentages. The proportions of women in the continuum of care, and at the different stages of this continuum, have been weighted. Multivariate logistic regression was used to identify the factors associated with non-completion of the different stages of the maternal health care continuum among the women included in this study.ResultsWe found that 26.9% of women had completed all stages of the maternal health care continuum, while 73.1% had not. While 56.7% received four antenatal visits, only 29.5% delivered under the care of a qualified healthcare professional. Key factors associated with discontinuity were not attending school (AOR 1.825: 1.594–2.089), unemployment (AOR 4.588: 3.983–5.285), having two or more living children (AOR 1.890: 1.016–1.296), and not receiving a free Long-Lasting Insecticidal Net at the first Antenatal Care.ConclusionMaternal care discontinuity is a major issue in Guinea. The country's Health Development Plan had set an expected level for maternal care which has not been met as of 2022. The completeness of care is influenced by various factors, including individual socio-demographic characteristics and factors related to the organization, availability, and quality of health services. To reduce maternal and child mortality rates, it is essential to improve interpersonal communication during antenatal care, ensure the availability of quality health services, and conduct a national study on maternal health service quality and maternal satisfaction. This will help establish a proper continuum of care for mothers and children.
Valorization of Date By-Products: Enhancement of Antioxidant and Antimicrobial Potentials through Fermentation
Authors: Khosravi Azin , Razavi Seyed Hadi , Castangia Ines , Manca Maria Letizia 
Published: September 2024

The by-products from three varieties of dates—Mozafati, Sayer, and Kabkab—were subjected to solid-state fermentation using Aspergillus niger alone or in co-culture with Lactiplantibacillus plantarum or Limosilactobacillus reuteri to enhance their phenolic and flavonoid content, along with antioxidant and antimicrobial activities. Solid-state fermentation, being environmentally friendly and cost-effective, is particularly suitable for agricultural residues. Significant increases (p < 0.05) in total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant power were observed post-fermentation, especially under co-culture conditions. The highest TPC (12.98 ± 0.29 mg GA/g) and TFC (1.83 ± 0.07 mg QE/g) were recorded in the co-culture fermentation of by-products from the Mozafati and Sayer varieties, respectively. HPLC analysis revealed changes in polyphenol profiles post-fermentation, with reductions in gallic and ferulic acids and increases in caffeic acid, p-coumaric acid, rutin, quercetin, and kaempferol. FT-IR analysis confirmed significant alterations in polyphenolic functional groups. Enhanced antimicrobial activity was also observed, with inhibition zones ranging from 8.26 ± 0.06 mm for Kabkab to 17.73 ± 0.09 mm for Mozafati. These results suggest that co-culture solid-state fermentation is a promising strategy for valorizing date by-products, with potential applications in nutraceuticals and/or pharmaceutical products and as valuable additives in the food industry.
Advancements and Challenges in Personalized Therapy for BRAF-Mutant Melanoma: A Comprehensive Review
Authors: Shebrain Abdulaziz , Idris Omer A. , Jawad Ali , Zhang Tiantian , Xing Yan 
Published: September 2024

Over the past several decades, advancements in the treatment of BRAF-mutant melanoma have led to the development of BRAF inhibitors, BRAF/MEK inhibitor combinations, anti-PD-1 therapy, and anti-CTLA4 therapy. Although these therapies have shown substantial efficacy in clinical trials, their sustained effectiveness is often challenged by the tumor microenvironment, which is a highly heterogeneous and complex milieu of immunosuppressive cells that affect tumor progression. The era of personalized medicine holds substantial promise for the tailoring of treatments to individual genetic profiles. However, tumor heterogeneity and immune evasion mechanisms contribute to the resistance to immunotherapy. Despite these challenges, tumor-infiltrating lymphocyte (TIL) therapy, as exemplified by lifileucel, has demonstrated notable efficacy against BRAF V600-mutant melanoma. Additionally, early response biomarkers, such as COX-2 and MMP2, along with FDG-PET imaging, offer the potential to improve personalized immunotherapy by predicting patient responses and determining the optimal treatment duration. Future efforts should focus on reducing the T-cell harvesting periods and costs associated with TIL therapy to enhance efficiency and accessibility.