bluuebunny/crossref_metadata_2025_split huggingface dataset:
МЕТОД ОЦІНЮВАННЯ РІВНЯ ПІДВИЩЕННЯ СТАНУ КІБЕРЗАХИСТУ ОБ’ЄКТІВ КРИТИЧНОЇ ІНФРАСТРУКТУРИ ДЕРЖАВИ
Authors: Корченко Олександр , Іванченко Євгенія , Бакалинський Олександр , Мялковський Данило , Зубков Денис 
Published: October 2024

У зв'язку зі зростанням загроз кібербезпеці, особливо для критичної інфраструктури держави, виникає необхідність у розробці та впровадженні ефективних методів оцінювання рівня кіберзахисту. Критична інфраструктура держави (енергетика, транспорт, медичні установи тощо) все більше стає залежною від інформаційних технологій. Порушення безпеки цих технологій може призвести до серйозних наслідків для життя та здоров'я громадян, а також економічних втрат. Багато країн встановлюють різні регулятивні вимоги стосовно кіберзахисту, наприклад, GDPR в Європейському Союзі або NIST у Сполучених Штатах. Це змушує організації, що управляють критичною інфраструктурою, активно шукати та впроваджувати ефективні методи оцінювання рівня кіберзахисту. Швидкий технологічний прогрес призводить до появи нових методів атак, для захисту від яких необхідно залучати різні ресурси (фінансові, людські, часові тощо) для створення нових більш ефективних засобів для підвищення стану кіберзахисту. Оцінка рівня такого стану в подальшому дасть можливість оцінити ефект від вкладених в безпеку ресурсів. Розроблений метод оцінки підвищення рівня кіберзахисту об'єктів критичної інфраструктури держави ґрунтується на моделі системи характеристик, спрямованої на оцінку стану кіберзахисту в Україні, та процедур формування лінгвістичних змінних, фазифікації інтервалів та побудови еталонів, формування множини характеристик об’єктів огляду, процесу первинного вимірювання, формуванню базових пар і асоціативних правил та візуалізації результатів, які формалізуються відповідними етапами, дозволяє реалізовувати процес оцінювання стану кіберзахисту об’єкту огляду критичної інфраструктури. Описаний метод може стати ефективним інструментом для аналізу та оцінки рівня кіберзахисту критичної інфраструктури держави з метою забезпечення національної безпеки та захисту від кіберзагроз. В подальшому необхідно побудувати систему, яка дозволить автоматизувати процес оцінювання підвищення стану кіберзахисту на об’єктах огляду.
Unveiling Disparities: Exploring Overmedication of Black Foster Care Youth and How Implicit Bias Contributes
Authors: Edwards Janice Berry , Selas Adachi 
Published: October 2024

Background:Black youth are overrepresented in the foster care system, and research is needed to reveal the impact of their overmedication (Cénat et al., 2021; Dettlaff & Boyd, 2020; Godoy et al., 2022; Lee et al., 2015; Montgomery, 2022; Williams-Butler, 2023).Objective:This article examines misdiagnoses, overprescribed psychotropics, and off-label medication use to address behavioral concerns (American Civil Liberties Union Maryland v. Maryland, 2023; Cullins & Moore, 2020; Fadus et al., 2020; Mizock & Harkins, 2011) and investigate the contribution of implicit bias to find equitable and nondiscriminatory solutions.Methods:A systematic literature review was conducted to identify themes surrounding racial disparities within the child welfare system. Articles that were published within the last five years were prioritized, except for those with unique findings or a specific lens of inquiry. Foundational references such as relevant legislation were also used to support the research questions.Findings:The literature reveals significant and clear disparities in the treatment of Black youth within the child welfare system. Black foster care youth are often medicated at disproportionately high rates.Conclusions:The findings suggest that more culturally intelligent interventions are necessary to ensure Black foster care youth receive adequate and appropriate assessment and treatment.
Halfaunisztikai adatok az Ipoly ipolytölgyesi duzzasztómű alatti szakaszáról
Authors: Sály Péter , Szalóky Zoltán , Maroda Ágnes 
Published: October 2024

Az ipolytölgyesi duzzasztó a Duna felől az első műtárgy, amely nehezíti a halak hosszirányú átjárhatóságát. Kutatásunkban a duzzasztómű alatti folyószakasz halfaunáját vizsgáltuk egyetlen alkalommal, 2023. szeptember 11-én, a kora őszre jellemző alacsony vízállásnál. Összesen 25 hal- és egy tízlábú rákfajt (cifrarák, Faxonius limosus) mutattunk ki. Az Ipoly alsó szakaszán Ipolytölgyesről korábban szakcikkekben közölt adatokhoz képest újszerű észlelésnek számít a védett széles durbincs, és megerősítő észlelésnek a fokozottan védett német bucó és magyar bucó előkerülése. A fogott halak nagy része a 0+ és juvenilis korosztályhoz tartozott, különösen a márna ivadéka volt jelen nagy számban. Ez azt jelzi, hogy az ipolytölgyesi folyószakasz értékes szaporodóhely és ivadékbölcső is egyben nem csak az Ipolyban élő, hanem a dunai halpopulációk számára is.
Assessment of the Level of NT-proBNP in Patients with Arterial Hypertension Aged 80 Years and Older, Depending on the Presence of Heart Failure and Senile Asthenia Syndrome
Authors: Safronenko V A. , Chesnikova A. I. 
Published: October 2024

Objectives. To evaluate the informativeness of the N-terminal brain-promoting natriuretic peptide (NT-proBNP) for the diagnosis of chronic heart failure (CHF), depending on the presence of senile asthenia syndrome (SSA) in patients with arterial hypertension (AH) 80 years and older.Materials and Methods. 320 patients with hypertension, depending on the presence of CHF and SSA, were divided into groups: group 1A — patients with hypertension, SSA and CHF (n=84), group 1B — patients with hypertension, SSA without CHF (n=77), group 2A — patients with hypertension, CHF without SSA (n=84), group 2B — patients with hypertension without CHF and without SSA (n=75). The CSA was identified by the questionnaire “Age is not a hindrance”. The level of NT-proBNP was determined in blood serum by enzyme immunoassay. ROC analysis was used to determine the threshold value of markers.Results. In patients with hypertension and SSA without CHF, the concentration of NT-proBNP in the blood is 2.3 times higher (p=0.003) compared with patients with hypertension without SSA and without CHF, which indicates the effect of SSA on the level of NT-proBNP. In patients with hypertension and CHF without SSA, the level of NT-proBNP is 4.3 times higher compared with patients with hypertension without SSA and without CHF (p<0.001), in whom the concentration of NT-proBNP was noted below the threshold level (106.2 pg/ml). In patients with hypertension and SSA and CHF, the highest concentrations of NT-proBNP were recorded, which are 2.9 times (p<0.001) higher than in “fragile” patients with hypertension without CHF and 1.5 times higher than in “strong” patients with hypertension and CHF (p<0.001). A new threshold level of NT-proBNP has been calculated for the diagnosis of CHF in patients with hypertension and SSA aged 80 years and older — 365.9 pg/ml.Conclusion. For the diagnosis of CHF in patients with hypertension 80 years and older without CSA, the NT-proBNP marker is informative, since, according to the data obtained, its level did not depend on the age of the patients. When using NT-proBNP to detect CHF in patients with hypertension and SSA 80 years and older, the calculated threshold marker level (365.9 pg/ml) should be used, since in these patients the concentration of NT-proBNP is increased, regardless of the presence of CHF.
The role of social work intervention in promoting mental health and resilience in communities: Ubuntu perspective
Authors: Sekgobela Tumelo , Budeli Nngodiseni Jimmy 
Published: October 2024

The prevalence of mental health illness is on the rise throughout the world. Mental health is increasingly one of the most overwhelming conditions that has an effect on the social functioning of individuals and families within communities. Mental Health Care Act, No 17 of 2002 of the South African government provides for the protection of individuals and communities against mental health. Still, people continue to experience mental health problems at a high rate. Social workers have a fundamental role to play in improving mental health services and outcomes for communities. Social work services have the potential to improve the lives of people with mental health conditions and build resilience in individuals and families. Resilience is a critical technique that assists individuals to function properly despite the challenges they may have experienced. Research has shown that people with mental health problems struggle to return back to normality. This article aims to explore the roles of social work intervention in promoting mental health and resilience in communities. The study was conducted by analyzing research or studies related to mental health and resilience. The study carried out comprehensive desktop electronic research to gather data and themes from previous studies. The analysis showed that mental health is still a major concern, and social workers have an important role to play in building resilience for individuals and families.
Lateral Femoral Condyle Stress Fracture in an Ultramarathoner
Authors: Luba Michael , Crawford Zachary , Utz Christopher , Smith Franklin 
Published: October 2024

Case:
A 62-year-old ultramarathon athlete presented to the clinic with right posterolateral knee pain for 3 to 4 weeks and muscle tightness. Magnetic resonance imaging demonstrated a right lateral femoral condyle fracture. The fracture was treated conservatively, with return full Ironman competition 14 months later.

Conclusion:
Femoral condyle fractures should be suspected in endurance athletes with nonspecific knee pain to prevent further injury. These fractures are rare, and more studies are needed to determine risk factors, risk classification, and optimal treatment protocol. With rising popularity of ultraendurance events, sports medicine physicians must educate patients on injury recognition and mitigation strategies.
Aplikasi sakarifikasi dan fermentasi simultan dalam produksi bioetanol dari rebung bambu
Authors: Ramadhani Griselda Happy , Syamsu Khaswar , Kartika Ika Amalia , Kartawiria Irvan Setiadi 
Published: October 2024

Bambu muda atau rebung memiliki sumber selulosa dan berpotensi untuk produksi bioetanol. Rebung juga memiliki kandungan lignin yang rendah yaitu 0,89%, sehingga memungkinkan untuk tidak dilakukan proses pre-treatment. Rebung bambu merupakan salah satu bahan yang berpotensi untuk produksi bioetanol mengingat laju produktivitas yang tinggi yaitu 8.124 kg/ha/tahun. Tujuan dari penelitian ini adalah menganalisis data produksi bioetanol dari rebung dengan teknik SSF menggunakan konsorsium mikroba Trichoderma reesei dan Saccharomyces cerevisiae. Mikroba T. reesei digunakan untuk menghasilkan enzim selulase yang menghidrolisis selulosa menjadi gula sederhana, sedangkan S. cerevisiae digunakan untuk memproduksi bioetanol dari gula yang dihasilkan sebelumnya. Sintesis bioetanol terdiri dari dua tahap utama yaitu hidrolisis dan fermentasi. Pada penelitian sebelumnya, proses hidrolisis dan fermentasi dilakukan secara terpisah menggunakan metode SHF (Separated Hydrolysis Fermentation), sedangkan pada penelitian ini dilakukan dengan menggunakan metode SSF (Simultaneous Saccharification and Fermentation) yang diharapkan menghasilkan efisiensi substrat, Yp/s, dan laju produktivitas bioetanol yang lebih tinggi dibandingkan metode SHF. Penelitian ini dilakukan menggunakan aerasi 1 vvm dan agitasi 125 rpm selama 72 jam. Hasil penelitian menunjukkan bahwa produksi bioetanol tertinggi di waktu 72 jam sebesar 6,94 g/L dengan laju produktivitas bioetanol 0,08 g/L/h dan rendemen produk (Yp/s) 0,19 g bioetanol/g substrat. Hasil penelitian ini menunjukkan bahwa rebung merupakan media yang layak untuk produksi bioetanol. Rebung memiliki kandungan selulosa yang potensial sebagai substrat untuk T. reesei dan terbukti menghasilkan bioetanol yang lebih tinggi dibandingkan teknik SHF dengan bambu pada penelitian sebelumnya.
Retrospective analysis of autologous bone marrow mesenchymal stem cells as adjuvant therapy in recurrent intrauterine adhesions
Authors: Wang Yu , Yin Li-Li , Sun Xiao-Fei , Yang Qing , Yu Yan-Qiu , Rong Yao-Xing , Chen Zhe , Wang Guangwei 
Published: October 2024

Abstract

We aimed to retrospectively analyze the efficacy and safety of autologous bone marrow mesenchymal stem cells (BM-MSCs) as adjuvant therapy for intrauterine adhesion (IUA) and endometrial repair. All patients had menstrual cramps and significantly increased menstrual flow during three rounds of perfusions with MSC compared to before treatment. However, this effect was reversed and there was no significant difference between the menstrual flow one year after treatment vs before treatment. The IUA scores after three rounds of treatment as well as one and two years after treatments were significantly lower compared to before surgery. No IUA recurrence was observed during the 2-year follow-up. Endometrial thickness had significantly increased during treatment. During the two-year follow-up period, one patient conceived naturally. One patient was successfully implanted after invitro fertilization and embryo transfer. Intrauterine perfusion of autologous BM-MSCs, assisted by adhesiolysis, was effective in preventing postoperative IUA recurrence and partially improved the reproductive prognosis.
Lacrimal Sac Cyst: A Retrospective Study on CT and CT-DCG Imaging Characteristics in Adults
Authors: Lan Gong , Lin Tong , Wen Xuetian , Wang Wushuang , Wang Yan 
Published: October 2024

Abstract

Background
Lacrimal sac cysts are rare lesions in the lacrimal drainage system (LDS), originating from the lacrimal sac epithelium. Differentiating these cysts from other lacrimal sac masses is challenging due to limited existing knowledge. This study aims to summarize CT and CT-DCG imaging characteristics of lacrimal sac cysts, aiding clinical classification and differential diagnosis, and to statistically analyze anatomical changes in the LDS of these patients.
Methods
This retrospective case-control study was conducted at the ENT Hospital of Fudan University. Patients diagnosed with lacrimal sac cysts were included, excluding those with certain surgeries, fractures, trauma, or other lacrimal sac masses. Controls were patients with a normal nasolacrimal drainage system undergoing CT examinations for eyeball atrophy or an intraocular foreign body. Anatomical assessments included nasolacrimal duct (NLD) width, lacrimal sac fossa structures, and nasal abnormalities.
Results
The study included 60 participants (50 females, 10 males) with a mean age of 47.43 ± 13.60 years. CT and CT-DCG imaging demonstrated four primary patterns: contrast agent reflux with no enhancement in lachrymal sac, partial thin rim enhancement of cyst wall, fluid level, and cystic lumen with a fluid-filled lightbulb sign. The average distances from the middle turbinate axilla (MTA) to the upper and lower limits of the lacrimal sac fossa (LSF) were 3.34 ± 3.37 mm and 11.00 ± 4.40 mm, respectively. Patients with lacrimal sac cysts exhibited widening of the lacrimal sac fossa, thinner frontal process thickness, and a larger lacrimal bone angle compared to controls, indicating bone remodeling due to the cysts.
Conclusions
Radiological imaging and detailed anatomical evaluations are crucial in diagnosing and managing lacrimal sac cysts. Identifying specific radiological patterns and anatomical changes improves diagnostic accuracy and surgical planning.
Exploration of the Mechanism of Juglone's Anti-Colorectal Cancer Effects Based on Network Pharmacology and Experimental Validation
Authors: DENG Yunting , ZAHNG Yanan , HUO Jinhai , WANG Weiming 
Published: October 2024

Abstract

Objectives This study aims to explore the mechanism of juglone's anticancer effects against colorectal cancer. The methods including network pharmacology prediction, molecular docking techniques, and cell experiments.
Background Colorectal cancer originates from the mucosal layer of the colon or rectum. It is the third most common cancer worldwide, accounting for approximately 10% of all cancer cases. It is also the second leading cause of cancerrelated deaths globally. Improving the treatment outcomes and survival rates of colorectal cancer is urgently needed. Juglone exhibits antiinflammatory, antiviral, and anticancer properties, and has been used to inhibit tumor cell growth with promising results. However, there is limited experimental research investigating the underlying mechanisms of juglone's inhibition of colorectal cancer.
Methods Utilizing network pharmacology to identify potential targets and pathways of juglone in combating colorectal cancer. Using molecular docking techniques to validate the interaction between Juglone and core targets of colorectal cancer. Evaluating the effects of juglone on colorectal cell proliferation/toxicity through cell experiments, and employing Western blot to assess the expression levels of target proteins, thereby elucidating the potential mechanism of action.
Results We identified that juglone's potential anticolorectal cancer effects involve 51 targets and 156 pathways. Juglone inhibits colorectal cancer cell proliferation in a dosedependent manner. Western blot experimental results indicate that juglone suppresses the development of colorectal cancer by modulating the expression levels of TP53 proteins.
ConclusionsJuglone exhibits multipathway, multitarget inhibition of colorectal cancer cell growth, providing a basis for clinical treatment of colorectal cancer.
The Impact of Acupuncture on Nausea and Vomiting in Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Kim Sung-A , Yeo Sujung , Lim Sabina 
Published: October 2024

Abstract

Background
Nausea and vomiting (NV) are among the most common adverse effects experienced by patients with cancer undergoing treatment worldwide. Because pharmacotherapy is often complicated by medication interactions and causes unwanted side effects, acupuncture may be an optimal candidate for these patients. The objective of this systematic review and meta-analysis was to assess the effectiveness and safety of acupuncture for treating NV in patients with cancer.
Methods
Three electronic databases and two clinical registry platforms were searched from inception to October 11th, 2023. Methodological quality was assessed using the Cochrane risk of bias (ROB).
Results
Fifteen randomized controlled trials (RCTs) were included in the qualitative review, whereas eight RCTs were analyzed for subsequent quantitative meta-analysis. Meta-analysis demonstrated that acupuncture had a significant effect on cancer patients with delayed vomiting (risk ratio (RR): 0.75; 95% confidence intervals (CI): 0.58 to 0.97; p = 0.03; I2 = 51%; n = 139). A subgroup analysis con-firmed no significant effect until day 3; however, it became significant on day 5 (RR: 0.56; 95% CI: 0.39 to 0.81; p = 0.002; I2 = 0%; n = 92). The most frequently used points were PC6, ST36, CV12, LI4, LR3, and ST25.
Conclusions
In this review, acupuncture showed significant effects on delayed vomiting in cancer patients undergoing various emetogenic cancer-related therapies. These results suggest that clinicians could expect substantial effectiveness with at least five days of acupuncture therapy, with acupuncture points PC6, ST36, CV12, LI4, LR3, and ST25.
Systematic review registration:
the PROSPERO database (registration number: CRD42022333811)
Characterization of natural killer (NK) cells in lung adenocarcinoma and construction of an NK risk signature based on single-cell and macromolecular RNA-seg data
Authors: Tian Chuanxi , Guo Yikun , Lv Tianyi , Yang Daowen 
Published: October 2024

Abstract

Background/Aims: Natural killer (NK) cells play a crucial role in tumor cell apoptosis, immune milieu regulation, and angiogenesis inhibition. This study aims to analyze the NK signature in lung adenocarcinoma (LUAD) and establish an NK cell-based risk signature for predicting the prognosis of LUAD patients. Methods: Single-cell RNA sequencing (scRNA-seq) data were obtained from the GEO database, while RNA-seq and microarray data from LUAD were simultaneously obtained from the TCGA and GEO databases. The scRNA-seq data were processed using the Seurat R package to identify NK clusters based on NK markers. Differentially expressed genes (DEGs) between normal and tumor samples were identified through differential expression analysis of LUAD-related data. Pearson correlation analysis was used to identify DEGs associated with NK clusters, followed by one-way Cox regression analysis to identify NK cell-related prognostic genes. Subsequently, Lasso regression analysis was employed to construct a risk signature based on NK cell-related prognostic genes. Finally, a column-line diagram model was constructed based on the risk signature and clinicopathological features. Results: Based on the scRNA-seq data, we identified five Natural killer (NK)cells clusters in lung adenocarcinoma (LUAD), with four of them showing associations with prognosis in LUAD. Out of 19,495 differentially expressed genes (DEGs), a total of 725 genes significantly associated with NK clusters were pinpointed and further narrowed down to form a risk profile comprising 13 genes. These 13 genes were primarily linked to 21 signaling pathways, including vascular smooth muscle contraction, RNA polymerase, and pyrimidine metabolism. Additionally, the risk profile exhibited significant associations with stromal and immune scores, as well as various immune cells. Multifactorial analysis indicated that the risk profile served as an independent prognostic factor for LUAD, and its efficacy in predicting the outcome of immunotherapy was validated. Furthermore, a novel column-line diagram integrating staging and NK-based risk profiles was developed, demonstrating strong predictability and reliability in prognostic forecasting for LUAD. Conclusion: The NK cell-based risk signature proves to be a valuable tool for predicting the prognosis of patients with lung adenocarcinoma (LUAD). Furthermore, a comprehensive understanding of NK cell characterization in LUAD could potentially unveil insights into the response of LUAD to immunotherapies and offer novel strategies for cancer treatment.
Full size cave 3D modelling using close range photogrammetry and comparison with laser scanning
Authors: Cazes Gael , Vernant Philippe , Baleux François , Giuliani Carla , Brugal Jean-Philip , Jouves Johan 
Published: October 2024

Abstract

Although underground topography methods have significantly evolved in the past two decades, it is still challenging and often costly to create comprehensive 3D models of caves or artificial cavities. Modern methods used by speleologists, involving the generation of a topographic ‘skeleton’ through laser pointer measurements, enable surveying extensive developments but suffer from a lack of resolution. Conversely, the use of Lidar technologies, while capable of obtaining sub-millimeter scans, implies the use of expensive equipment and precision electronics often unsuitable for this harsh underground environment. In this study, we propose to test the use of low-cost cameras (action-cam type) for the complete 3D modeling of a cave through photogrammetry aiming to compare the results with a Lidar survey based on a series of topographic markers precisely measured with a total station. Our findings indicate that photogrammetry is an approach significantly faster and more adaptable in the field, leading to a substantial reduction in artifacts and shadows compared to static Lidar usage. Although post-processing involving image correlation is more computationally intensive for photogrammetry, we explore various strategies to reduce the calculation times. Ultimately, we demonstrate that the residual positioning errors on the topographic markers are of similar centimetric magnitude to those of Lidar. Recent advancements in computing capabilities now make it feasible to consider the use of photogrammetry for extended underground developments, presenting a promising alternative to the more conventionally employed Lidar in such contexts.