bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESAFIOS DA MOBILIDADE HUMANA E ESPACIAL EM SERRA/ES NA CONTEMPORANEIDADE/ Challenges of human and space mobility in the municipality of Serra/Es in contemporaneity
Authors: PEREIRA AROEIRA SUCE DOURINE , DADALTO MARIA CRISTINA 
Published: January 2018

Este artigo visa debater o fenômeno da mobilidade humana na história recente do município de Serra, Espírito Santo. A reflexão se desenvolve analisando a interface entre os processos de industrialização, de migração e o padrão de desigualdade espacial observada no lugar entre os anos 1960 e 2010. Tem como fonte pesquisas bibliográfica e documental com adoção de fontes primária e secundária. Parte do pressuposto de que o fenômeno migratório ali estabelecido tem uma perspectiva laboral e se retroalimenta da rede de trocas e de circularidade de ideias entre os migrantes. Avalia que a cidade, dominada pela lógica do capital, manifesta o aumento populacional, o descarte da força de trabalho e produz uma dívida social que repercute no tempo presente. ABSTRACTThis article aims to discuss the phenomenon of human mobility in the recent history of the municipality of Serra, Espírito Santo. The reflection is developed by analyzing the interface between the processes of industrialization, migration and the pattern of spatial inequality in the place between the years 1960 and 2010. It has as source bibliographical and documentary research with adoption of primary and secondary sources. Is parts of the assumption that the migratory phenomenon established there has a labor perspective and is fed by the network of exchanges and circularity of ideas among migrants. It evaluates that the city, dominated by the logic of capital, manifests the population increase, the discard of the labor force, and produces a social debt that reverberates in the present time. Keywords: Serra; Migration; Inequalities.
Moving towards open science? Conference report: the 9th Conference on Open Access Scholarly Publishing, Lisbon, September 20–21, 2017
Authors: Eriksson Jörgen , Lagvik Christer , Nolin Emma 
Published: January 2018

The Conference on Open Access Scholarly Publishing, COASP, is held annually with the aim of reaching professional publishing organizations, independent publishers and university presses, as well as librarians, university administrators and other stakeholders. Here, we outline some themes and highlights from this year’s conference.
Profiling of subgingival plaque biofilm microbiota in female adult patients with clear aligners: a three-month prospective study
Authors: Guo Runzhi , Zheng Yunfei , Liu Hao , Li Xiaobei , Jia Lingfei , Li Weiran 
Published: January 2018

Background
Clear aligners are well known for facilitating oral hygiene maintenance and decreasing susceptibility to periodontal diseases as compared to conventional fixed appliances. However, few research studies focus on the subgingival microbial community during clear aligner treatment (CAT). Hence, this study investigates changes of the subgingival microbial community and its association with clinical characteristics during the first three months of CAT.

Methods
Ten female patients with clear aligners were enrolled in this study. Subgingival plaque samples were obtained at three time points: before orthodontic treatment (T0), one month after orthodontic treatment (T1) and three months after orthodontic treatment (T2). DNA was then extracted from plaque samples and analyzed by 16S rRNA gene sequencing. Periodontal examinations, including plaque index (PI) and gingival bleeding index (GBI) measurements were also recorded.

Results
The plaque indices (PIs) and gingival bleeding indices (GBIs) were slightly increased at T1 and T2, but no statistically significant difference was found. The alpha diversity indices, including the ACE, Chao1, Shannon indices, all showed a declining trend without significance, and a rising trend in the Simpson diversity index was observed. The weighted UniFrac distance was significantly higher at T1 and T2 compared with T0. Principal Coordinates Analysis (PCoA) demonstrated that the communities at T0 tended to cluster apart from the communities at T1 and T2. The relative abundance of the phylum Firmicutes and genus Mycoplasma was significantly increased at T0 compared with T2. There was no significant difference in the relative abundance of periodontal pathogens at the genus and species levels or core microorganisms at the genus level.

Conclusion
A slightly decreasing microbial diversity with a significant change of microbial structure was found during the first three-month clear aligner treatment (CAT). However, subjects receiving clear aligner treatment were free from periodontal diseases with relatively stable levels of periodontal microorganisms and core microorganisms. Thus, our preliminary findings indicated that clear aligners induced nonpathogenic changes of the subgingival microbiome in the first three-month treatment.
Reversible optical control of F1Fo‐ATP synthase using photoswitchable inhibitors
Authors: Eisel Bianca , Hartrampf Felix W.W. , Meier Thomas , Trauner Dirk 
Published: January 2018

F1Fo‐ATP synthase is one of the best studied macromolecular machines in nature. It can be inhibited by a range of small molecules, which include the polyphenols, resveratrol and piceatannol. Here, we introduce Photoswitchable Inhibitors of ATP Synthase, termed PIAS, which were synthetically derived from these polyphenols. They can be used to reversibly control the enzymatic activity of purified yeast Yarrowia lipolyticaATP synthase by light. Our experiments indicate that the PIAS bind to the same site in the ATP synthase F1 complex as the polyphenols in their trans form, but they do not bind in their cis form. The PIAS could be useful tools for the optical precision control of ATP synthase in a variety of biochemical and biotechnological applications.
Multifunctional Sandwich‐Structured Electrolyte for High‐Performance Lithium–Sulfur Batteries
Authors: Qu Hongtao , Zhang Jianjun , Du Aobing , Chen Bingbing , Chai Jingchao , Xue Nan , Wang Longlong , Qiao Lixin , Wang Chen , Zang Xiao , Yang Jinfeng , Wang Xiaogang , Cui Guanglei 
Published: January 2018

AbstractDue to its high theoretical energy density (2600 Wh kg−1), low cost, and environmental benignity, the lithium–sulfur (Li‐S) battery is attracting strong interest among the various electrochemical energy storage systems. However, its practical application is seriously hampered by the so‐called shuttle effect of the highly soluble polysulfides. Herein, a novel design of multifunctional sandwich‐structured polymer electrolyte (polymer/cellulose nonwoven/nanocarbon) for high‐performance Li‐S batteries is demonstrated. It is verified that Li‐S battery with this sandwich‐structured polymer electrolyte delivers excellent cycling stability (only 0.039% capacity decay cycle−1 on average exceeding 1500 cycles at 0.5 C) and rate capability (with a reversible capacity of 594 mA h g−1 at 4 C). These electrochemical performances are attributed to the synergistic effect of each layer in this unique sandwich‐structured polymer electrolyte including steady lithium stripping/plating, strong polysulfide absorption ability, and increased redox reaction sites. More importantly, even with high sulfur loading of 4.9 mg cm−2, Li‐S battery with this sandwich‐structured polymer electrolyte can deliver high initial areal capacity of 5.1 mA h cm−2. This demonstrated strategy here may open up a new era of designing hierarchical structured polymer electrolytes for high‐performance Li‐S batteries.
Transparent Nanoscale Polyimide Gate Dielectric for Highly Flexible Electronics
Authors: Park Saungeun , Chang Hsiao‐Yu , Rahimi Somayyeh , Lee Alvin L. , Tao Li , Akinwande Deji 
Published: January 2018

AbstractTransparent and solution‐processable nanoscale polyimide (NPI) films less than 100 nm thick and their applications as flexible gate dielectrics for 2D‐materials‐based transistor devices are reported. Stable electrical performances of NPI dielectric under high tensile strains up to 10% are demonstrated by in situ bending experiments. A welcome benefit of the NPI nanoscale thickness is that the optical transparency is improved over 84% across the visible spectrum compared to conventional thick polyimide, indicating suitability for transparent electronics, such as displays and sensors. Prototypical 2D active materials, molybdenum disulfide (MoS2), and graphene using NPI gate dielectric show outstanding thin‐film transistors (TFTs) properties comparable to performances of similar devices using atomic layer deposition (ALD) gate dielectrics. For instance, MoS2 FETs with NPI dielectric affords maximum field‐effect mobility of 30 cm2 V−1 s−1 and ON/OFF current ratio >107. Graphene FETs (GFETs), fabricated with NPI dielectric, also show DC and radio frequency (RF) performances comparable to similar devices with high‐κ dielectrics, such as maximum carrier mobility of ≈5170 cm2 V−1 s−1. An extrinsic cutoff frequency ≈6.5 GHz is achieved, which reveals that NPI is also a suitable dielectric for flexible RF TFTs for wireless communication systems.
Modulating Cell‐Surface Receptor Signaling and Ion Channel Functions by In Situ Glycan Editing
Authors: Jiang Hao , López‐Aguilar Aimé , Meng Lu , Gao Zhongwei , Liu Yani , Tian Xiao , Yu Guangli , Ovryn Ben , Moremen Kelley W. , Wu Peng 
Published: January 2018

AbstractGlycans anchored on cell‐surface receptors are active modulators of receptor signaling. A strategy is presented that enforces transient changes to cell‐surface glycosylation patterns to tune receptor signaling. This approach, termed in situ glycan editing, exploits recombinant glycosyltransferases to incorporate monosaccharides with linkage specificity onto receptors in situ. α2,3‐linked sialic acid or α1,3‐linked fucose added in situ suppresses signaling through epidermal growth factor receptor and fibroblast growth factor receptor. We also applied the same strategy to regulate the electrical signaling of a potassium ion channel–human ether‐à‐go‐go‐related gene channel. Compared to gene editing, no long‐term perturbations are introduced to the treated cells. In situ glycan editing therefore offers a promising approach for studying the dynamic role of specific glycans in membrane receptor signaling and ion channel functions.
Lanthanoidkomplexe mit Trizink‐Kronenether als Katalysatoren für die alternierende Copolymerisation von Epoxid und CO2: eine durch Carboxylat‐Anionen kontrollierte Telomerisierung
Authors: Nagae Haruki , Aoki Ryota , Akutagawa Shin‐nosuke , Kleemann Julian , Tagawa Risa , Schindler Tobias , Choi Gyeongshin , Spaniol Thomas P. , Tsurugi Hayato , Okuda Jun , Mashima Kazushi 
Published: January 2018

AbstractEine neue Familie von Heterometallkatalysatoren auf Basis von dreifach metallierten makrocyclischen Tris(salen)‐Liganden und Seltenerdmetallen wurde hergestellt und strukturell charakterisiert. Das LaZn3‐System mit seinen anionischen Liganden wie Acetat spielt eine zentrale Rolle bei der katalysierten alternierenden Copolymerisation von Cyclohexenoxid (CHO) und CO2 und liefert ein Produkt mit einem hohen Gehalt an Carbonatverknüpfungen. Bei den Lanthanoiden zeigt das CeZn3‐System eine hohe katalytische Aktivität mit einer Wechselzahl (TOF) von über 370 h−1. Die NMR‐spektroskopische Analyse des Komplexes und die Bestimmung der Endgruppen im Polymer weisen auf einen schnellen Austausch der Acetatliganden hin. Die koordinierten Acetate werden nicht nur untereinander, sondern auch gegen zugesetzte Carboxylat‐Anionen ausgetauscht. Mit solch einzigartigen Eigenschaften ist dieses System das erste Beispiel für eine als Telomerisierung ablaufende Copolymerisation von CHO und CO2.
Mechanofluorochromic Carbon Nanodots: Controllable Pressure‐Triggered Blue‐ and Red‐Shifted Photoluminescence
Authors: Liu Cui , Xiao Guanjun , Yang Mengli , Zou Bo , Zhang Zhi‐Ling , Pang Dai‐Wen 
Published: January 2018

AbstractMechanofluorochromic materials, which change their photoluminescence (PL) colors in responding to mechanical stimuli, can be used as mechanosensors, security papers, and photoelectronic devices. However, traditional mechanofluorochromic materials can only be adjusted to a monotone direction upon the external stimuli. Controllable pressure‐triggered blue‐ and red‐shifted PL is reported for C‐dots. The origin of mechanofluorochromism (MFC) in C‐dots is interpreted based on structure–property relationships. The carbonyl group and the π‐conjugated system play key roles in the PL change of C‐dots under high pressure. As the pressure increases, the enhanced π–π stacking of the π‐conjugated system causes the red‐shift of PL, while the conversion of carbonyl groups eventually induces a blue‐shift. Together with their low toxicity, good hydrophilicity, and small size, the tunable MFC property would boost various potential applications of C‐dots.
Thermoregulated Phase‐Transition Synthesis of Two‐Dimensional Carbon Nanoplates Rich in sp2 Carbon and Unimodal Ultramicropores for Kinetic Gas Separation
Authors: Zhang Lu‐Hua , Li Wen‐Cui , Liu Hong , Wang Quan‐Gao , Tang Lei , Hu Qing‐Tao , Xu Wen‐Jing , Qiao Wei‐Hong , Lu Zhong‐Yuan , Lu An‐Hui 
Published: January 2018

AbstractThe development of highly selective, chemically stable and moisture‐resistant adsorbents is a key milestone for gas separation. Porous carbons featured with random orientation and cross‐linking of turbostratic nanodomains usually have a wide distribution of micropores. Here we have developed a thermoregulated phase‐transition‐assisted synthesis of carbon nanoplates with more than 80 % sp2 carbon, unimodal ultramicropore and a controllable thickness. The thin structure allows oriented growth of carbon crystallites, and stacking of crystallites in nearly parallel orientation are responsible for the single size of the micropores. When used for gas separation from CH4, carbon nanoplates exhibit high uptakes (5.2, 5.3 and 5.1 mmol g−1) and selectivities (7, 71 and 386) for CO2, C2H6 and C3H8 under ambient conditions. The dynamic adsorption capacities are close to equilibrium uptakes of single components, further demonstrating superiority of carbon nanoplates in terms of selectivity and sorption kinetics.
Formation of the Periotic Space During the Early Fetal Period in Humans
Authors: Ishikawa Aoi , Ohtsuki Sae , Yamada Shigehito , Uwabe Chigako , Imai Hirohiko , Matsuda Tetsuya , Takakuwa Tetsuya 
Published: January 2018

ABSTRACTThe inner ear is a very complicated structure, composed of a bony labyrinth (otic capsule; OC), membranous labyrinth, with a space between them, named the periotic labyrinth or periotic space. We investigated how periotic tissue fluid spaces covered the membranous labyrinth three‐dimensionally, leading to formation of the periotic labyrinth encapsulated in the OC during human fetal development. Digital data sets from magnetic resonance images and phase‐contrast X‐ray tomography images of 24 inner ear organs from 24 human fetuses from the Kyoto Collection (fetuses in trimesters 1 and 2; crown—rump length: 14.4–197 mm) were analyzed. The membranous labyrinth was morphologically differentiated in samples at the end of the embryonic period (Carnegie stage 23), and had grown linearly to more than eight times in size during the observation period. The periotic space was first detected at the 35‐mm samples, around the vestibule and basal turn of the cochlea, which elongated rapidly to the tip of the cochlea and semicircular ducts, successively, and almost covered the membranous labyrinth at the 115‐mm CRL stage or later. In those samples, several ossification centers were detected around the space. This article thus demonstrated that formation of the membranous labyrinth, periotic space (labyrinth), and ossification of the OC occurs successively, according to an intricate timetable. Anat Rec, 301:563–570, 2018. © 2018 Wiley Periodicals, Inc.
Variable selection – A review and recommendations for the practicing statistician
Authors: Heinze Georg , Wallisch Christine , Dunkler Daniela 
Published: January 2018

AbstractStatistical models support medical research by facilitating individualized outcome prognostication conditional on independent variables or by estimating effects of risk factors adjusted for covariates. Theory of statistical models is well‐established if the set of independent variables to consider is fixed and small. Hence, we can assume that effect estimates are unbiased and the usual methods for confidence interval estimation are valid. In routine work, however, it is not known a priori which covariates should be included in a model, and often we are confronted with the number of candidate variables in the range 10–30. This number is often too large to be considered in a statistical model. We provide an overview of various available variable selection methods that are based on significance or information criteria, penalized likelihood, the change‐in‐estimate criterion, background knowledge, or combinations thereof. These methods were usually developed in the context of a linear regression model and then transferred to more generalized linear models or models for censored survival data. Variable selection, in particular if used in explanatory modeling where effect estimates are of central interest, can compromise stability of a final model, unbiasedness of regression coefficients, and validity ofp‐values or confidence intervals. Therefore, we give pragmatic recommendations for the practicing statistician on application of variable selection methods in general (low‐dimensional) modeling problems and on performing stability investigations and inference. We also propose some quantities based on resampling the entire variable selection process to be routinely reported by software packages offering automated variable selection algorithms.
Balancing hydrophobicity and sequence pattern to influence self‐assembly of amphipathic peptides
Authors: Betush Ria J. , Urban Jennifer M. , Nilsson Bradley L. 
Published: January 2018

AbstractAmphipathic peptides with alternating polar and nonpolar amino acid sequences efficiently self‐assemble into functional β‐sheet fibrils as long as the nonpolar residues have sufficient hydrophobicity. For example, the Ac‐(FKFE)2‐NH2 peptide rapidly self‐assembles into β‐sheet bilayer nanoribbons, while Ac‐(AKAE)2‐NH2 fails to self‐assemble under similar conditions due to the significantly reduced hydrophobicity and β‐sheet propensity of Ala relative to Phe. Herein, we systematically explore the effect of substituting only two of the four Ala residues at various positions in the Ac‐(AKAE)2‐NH2 peptide with amino acids of increasing hydrophobicity, β‐sheet potential, and surface area (including Phe, 1‐naphthylalanine (1‐Nal), 2‐naphthylalanine (2‐Nal), cyclohexylalanine (Cha), and pentafluorophenylalanine (F5‐Phe)) on the self‐assembly propensity of the resulting sequences. It was found that double Phe variants, regardless of the position of substitution, failed to self‐assemble under the conditions used in this study. In contrast, all double 1‐Nal and 2‐Nal variants readily self‐assembled, albeit at differing rates depending on the substitution patterns. To determine whether this was due to hydrophobicity or side chain surface area, we also prepared double Cha and F5‐Phe variant peptides (both side chain groups are more hydrophobic than Phe). Each of these variants also underwent effective self‐assembly, with the aromatic F5‐Phe peptides doing so with greater efficiency. These findings provide insight into the role of amino acid hydrophobicity and sequence pattern on self‐assembly proclivity of amphipathic peptides and on how targeted substitutions of nonpolar residues in these sequences can be exploited to tune the characteristics of the resulting self‐assembled materials.
Mini review: Instrumentation for vibrational circular dichroism spectroscopy, still a role for dispersive instruments
Authors: Keiderling Timothy A. , Lakhani Ahmed 
Published: January 2018

AbstractVibrational circular dichroism (VCD) has become a standard method for determination of absolute stereochemistry, particularly now that reliable commercial instrumentation has become available. These instruments use a now well‐documented Fourier transform infrared‐based approach to measure VCD that has virtually displaced initial dispersive infrared‐based designs. Nonetheless, many papers have appeared reporting dispersive VCD data, especially for biopolymers. Instrumentation designed with these original methods, particularly after more recent updates optimizing performance in selected spectral regions, has been shown still to have advantages for specific applications. This article presents a mini‐review of dispersive VCD instrument designs and includes sample spectra obtained for various biopolymer (particularly peptide) samples. Complementary reviews of Fourier transform‐VCD designs are broadly available.
New tools and resources in metabolomics: 2016–2017
Authors: Misra Biswapriya B. 
Published: January 2018

AbstractRapid advances in mass spectrometry (MS) and nuclear magnetic resonance (NMR)‐based platforms for metabolomics have led to an upsurge of data every single year. Newer high‐throughput platforms, hyphenated technologies, miniaturization, and tool kits in data acquisition efforts in metabolomics have led to additional challenges in metabolomics data pre‐processing, analysis, interpretation, and integration. Thanks to the informatics, statistics, and computational community, new resources continue to develop for metabolomics researchers. The purpose of this review is to provide a summary of the metabolomics tools, software, and databases that were developed or improved during 2016–2017, thus, enabling readers, developers, and researchers access to a succinct but thorough list of resources for further improvisation, implementation, and application in due course of time.
A scalable traffic engineering technique in an SDN‐based data center network
Authors: Bastam Mostafa , Sabaei Masoud , Yousefpour Ruhollah 
Published: January 2018

AbstractData center has recently emerged as a common infrastructure that includes numerous servers and host diversity of applications and cloud‐based services. In this paper, a dynamic method is proposed for traffic engineering in software‐defined data center networks helping to design an optimal demand‐path mapping with a tolerable computational complexity. To achieve the aim of this study, we used a linear programming to define the problem statement and then modeled the problem as a Path‐based multicommodity flow. To reduce time complexity, first, a decomposition technique is used to divide the problem model into smaller subproblems, which are then solved simultaneously by applying parallelizing techniques (ie, multiple‐core computing and OpenMP). Next, a suitable iterative algorithm is utilized to quickly converge subproblem solutions leading to an answer to the master problem. Simulation results show that solving time is considerably improved compared with a number of reported schemes devoted to this topic. In addition, implementing the proposed method serially yields an optimum solution, which takes significantly shorter time to reach than that of the generic (the LP model that is not decomposed) approach.