bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Design, Development, and Reliability Testing of a New Innovative Device to Measure Ankle Joint Dorsiflexion
Authors: Charles James 
Published: October 2016

Background:In clinical and research settings, ankle joint dorsiflexion needs to be reliably measured. Dorsiflexion is often measured by goniometry, but the intrarater and interrater reliability of this technique have been reported to be poor. Many devices to measure dorsiflexion have been developed for clinical and research use. An evaluation of 12 current tools showed that none met all of the desirable criteria. The purpose of this study was to design and develop a device that rates highly in all of the criteria and that can be proved to be highly reliable.Methods:While supine on a treatment table, 14 participants had a foot placed in the Charles device and ankle joint dorsiflexion measured and recorded three times with a digital inclinometer. The mean of the three readings was determined to be the ankle joint dorsiflexion.Results:The analysis used was intraclass correlation coefficient (ICC). There was very little difference in ICC single or average measures between left and right feet, so data were pooled (N = 28). The single-measure ICC was 0.998 (95% confidence interval, 0.996-0.998). The average-measure ICC was 0.998 (95% confidence interval, 0.995-0.999). Limits of agreement for the average measure were also very good: −1.30° to 1.65°.Conclusions:The Charles device meets all of the desirable criteria and has many innovative features, increasing its appropriateness for clinical and research applications. It has a suitable design for measuring dorsiflexion and high intrarater and interrater reliability.
Insight and Outlook – A Review of the Royal Society of Chemistry’s Open Access Program
Authors: Popov Mikhail 
Published: October 2016

Watch the VIDEO of the presentation.To support the transition to Open Access (OA ), the Royal Society of Chemistry introduced the Gold for Gold initiative in 2012, rewarding all institutions subscribing to RSC Gold with voucher codes to make papers available via OA, free of charge.The ‘Gold for Gold’ scheme started as a pilot for the UK only and was rolled out to universities and research institutes in the rest of the world in 2013. In 2015 more than 700 customers qualified for this project and over 10,000 voucher codes were issued.We will provide background information and figures about the usage of the vouchers and acceptance of the project. We will review if there is a traceable record of success, what effect the Gold for Gold project has on the RSC publications, if there is any measurable global impact; and finally what changes to expect in the future.With this presentation we want to support and add to the discussion around transition to Open Access, to promote Open Science and encourage further development of open access policies.
Microchannel-free collection and single-cell isolation of yeast cells in a suspension using liquid standing wave
Authors: Matsutani Akihiro , Takada Ayako 
Published: October 2016

Abstract
We demonstrate a microchannel-free collection method at nodes of liquid standing waves by the vertical vibration of a suspension including yeast cells. The pattern formation of the collection of cells using standing waves in a suspension was investigated by varying the frequency and waveform of vibrations. The single-cell isolation of yeast cells was achieved using a microenclosure array set at the nodes. In addition, we succeeded in the microchannel-free collection of yeast cells in a suspension, where patterns were formed by tapping vibration. The proposed technique is very simple and we believe that it will be useful for single-cell analysis and investigation.
Single-agent maintenance therapy for advanced non-small cell lung cancer (NSCLC): a systematic review and Bayesian network meta-analysis of 26 randomized controlled trials
Authors: Wang Qinxue , Huang Haobin , Zeng Xiaoning , Ma Yuan , Zhao Xin , Huang Mao 
Published: October 2016

BackgroundThe benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have been reported, clinicians still have little guidance on how to select the most efficacious single-agent regimen. Hence, we present a network meta-analysis to assess the comparative treatment efficacy of several single-agent maintenance therapy regimens for stage III/IV NSCLC.MethodsA comprehensive literature search of public databases and conference proceedings was performed. Randomized clinical trials (RCTs) meeting the eligible criteria were integrated into a Bayesian network meta-analysis. The primary outcome was overall survival (OS) and the secondary outcome was progression free survival (PFS).ResultsA total of 26 trials covering 7,839 patients were identified, of which 24 trials were included in the OS analysis, while 23 trials were included in the PFS analysis. Switch-racotumomab-alum vaccine and switch-pemetrexed were identified as the most efficacious regimens based on OS (HR, 0.64; 95% CrI, 0.45–0.92) and PFS (HR, 0.54; 95% CrI, 0.26–1.04) separately. According to the rank order based on OS, switch-racotumomab-alum vaccine had the highest probability as the most effective regimen (52%), while switch-pemetrexed ranked first (34%) based on PFS.ConclusionsSeveral single-agent maintenance therapy regimens can prolong OS and PFS for stage III/IV NSCLC. Switch-racotumomab-alum vaccine maintenance therapy may be the most optimal regimen, but should be confirmed by additional evidence.
Nonlinear temperature effects on multifractal complexity of metabolic rate of mice
Authors: Labra Fabio A. , Bogdanovich Jose M. , Bozinovic Francisco 
Published: October 2016

Complex physiological dynamics have been argued to be a signature of healthy physiological function. Here we test whether the complexity of metabolic rate fluctuations in small endotherms decreases with lower environmental temperatures. To do so, we examine the multifractal temporal scaling properties of the rate of change in oxygen consumptionr(VO2), in the laboratory mouseMus musculus, assessing their long range correlation properties across seven different environmental temperatures, ranging from 0 °C to 30 °C. To do so, we applied multifractal detrended fluctuation analysis (MF-DFA), finding thatr(VO2)fluctuations show two scaling regimes. For small time scales below the crossover time (approximately 102s), either monofractal or weak multifractal dynamics are observed depending on whetherTa< 15 °C orTa> 15 °C respectively. For larger time scales,r(VO2)fluctuations are characterized by an asymptotic scaling exponent that indicates multifractal anti-persistent or uncorrelated dynamics. For both scaling regimes, a generalization of the multiplicative cascade model provides very good fits for the Renyi exponentsτ(q), showing that the infinite number of exponentsh(q)can be described by only two independent parameters,aandb. We also show that the long-range correlation structure ofr(VO2)time series differs from randomly shuffled series, and may not be explained as an artifact of stochastic sampling of a linear frequency spectrum. These results show that metabolic rate dynamics in a well studied micro-endotherm are consistent with a highly non-linear feedback control system.
Effects of unstable flow on solute transport in the marsh soil and exchange with coastal water
Authors: Shen Chengji , Zhang Chenming , Jin Guangqiu , Kong Jun , Li Ling 
Published: October 2016

AbstractRecent studies of marsh hydraulics have focused on tide‐induced pore water circulation as the main drive for solute transport in the marsh soil and exchange with coastal water. Our study revealed another important mechanism provided by unstable fingering flow, which largely modified solute transport paths. In the marsh interior, downward penetration of salt fingers forced ambient pore water and solute plumes to move upward and exit the marsh soil through marsh platform at relatively high concentrations, up to 2 orders of magnitude higher than exit solute concentrations at the tidal creek bed. The mixing of solute with ambient pore water in the marsh interior was intensified greatly by fingering flow. A critical distance to the creek was determined based on a field‐scale model simulation to distinguish tidal circulation‐dominated and fingering flow‐dominated solute transport zones. The new transport mechanism has implications for understanding the fate of solutes in particularly salt marshes of low creek densities.
Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
Authors: Bischof Gérard N. , Jessen Frank , Fliessbach Klaus , Dronse Julian , Hammes Jochen , Neumaier Bernd , Onur Oezguer , Fink Gereon R. , Kukolja Juraj , Drzezga Alexander , van Eimeren Thilo ,   the Alzheimer's Disease Neuroimaging Initiative
Published: October 2016

AbstractIn a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV‐1451) and beta‐amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG‐PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta‐amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta‐amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.
Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy
Authors: Bar‐Klein Guy , Klee Rebecca , Brandt Claudia , Bankstahl Marion , Bascuñana Pablo , Töllner Kathrin , Dalipaj Hotjensa , Bankstahl Jens P. , Friedman Alon , Löscher Wolfgang 
Published: October 2016

ObjectiveAcquired epilepsy is a devastating long‐term risk of various brain insults, including trauma, stroke, infections, and status epilepticus (SE). There is no preventive treatment for patients at risk. Attributable to the complex alterations involved in epileptogenesis, it is likely that multitargeted approaches are required for epilepsy prevention. We report novel preclinical findings with isoflurane, which exerts various nonanesthetic effects that may be relevant for antiepileptogenesis.MethodsThe effects of isoflurane were investigated in two rat models of SE‐induced epilepsy: intrahippocampal kainate and systemic administration of paraoxon. Isoflurane was either administered during (kainate) or after (paraoxon) induction of SE. Magnetic resonance imaging was used to assess blood–brain barrier (BBB) dysfunction. Positron emission tomography was used to visualize neuroinflammation. Long‐term electrocorticographic recordings were used to monitor spontaneous recurrent seizures. Neuronal damage was assessed histologically.ResultsIn the absence of isoflurane, spontaneous recurrent seizures were common in the majority of rats in both models. When isoflurane was administered during kainate injection, duration and severity of SE were not affected, but only few rats developed spontaneous recurrent seizures. A similar antiepileptogenic effect was found when paraoxon‐treated rats were exposed to isoflurane after SE. Moreover, in the latter model, isoflurane prevented BBB dysfunction and neurodegeneration, whereas isoflurane reduced neuroinflammation in the kainate model.InterpretationGiven that isoflurane is a widely used volatile anesthetic, and is used for inhalational long‐term sedation in critically ill patients at risk to develop epilepsy, our findings hold a promising potential to be successfully translated into the clinic. Ann Neurol 2016;80:896–908
Community‐Based Learning and Critical Community Psychology Practice: Conducive and Corrosive Aspects
Authors: Hart Andrew , Akhurst Jacqui 
Published: October 2016

AbstractCommunity‐based learning (CBL) has been more recently introduced into some psychology programmes in the UK than in the USA, where it has existed for a number of decades in the form of ‘service learning’. CBL holds promise as a means of promoting and developing critical community psychology practice, but there are risks involved in its acritical adoption in the psychology curriculum. If associated power dynamics are not considered, CBL has the capacity to serve neoliberal interests and perpetuate, rather than challenge, oppressive social relations.This article examines ways in which CBL can be both conducive and corrosive to critical community psychology practice. Drawing on interdisciplinary literature, it explores ways in which students participating in CBL can be vulnerable to exploitation—both as victims and perpetrators—through collusion and cultural voyeurism.Consideration is given to ways of resisting institutional and other pressures to comply uncritically with the demands of the ‘employability agenda’. These include the importance of facilitated reflective processes in associated modules, to consider aspects of the interactions of people and systems. The article concludes that whilst CBL is inherently risky and involves discomfort for students, this enables development of a more informed consciousness where truly participatory work evolves towards greater social justice. Copyright © 2016 John Wiley & Sons, Ltd.
Polyaniline‐Coated Platinum Nanocube Assemblies as Enhanced Methanol Oxidation Electrocatalysts
Authors: Sun Xiuhui , Zhang Nan , Huang Xiaoqing 
Published: October 2016

AbstractIn this work, we report the design of a new class of core–shell superstructure consisting of Pt nanocube assemblies (NCAMs) as the active core and polyaniline (PANI) as the protective and conductive shell as a highly efficient methanol oxidation reaction (MOR) electrocatalyst. The assembly feature of the nanocubes and the unique π‐conjugated structure of PANI make PANI‐coated Pt NCAMs a promising candidate as a catalyst for the MOR that is generally more active and stable than uncoated Pt NCAMs and commercial Pt/C. At the same time, the PANI‐coated Pt NCAMs exhibit high stability during long‐term potential cycles. This work provides a unique assembly strategy to boost the catalytic activity and stability of electrocatalysts further.
ChemInform Abstract: Synthesis of Spiro‐Lactams and Polysubstituted Pyrroles via Ceric Ammonium Nitrate‐Mediated Oxidative Cyclization of N‐Furan‐2‐ylmethyl‐β‐enaminones.
Authors: Peng Hui , Li Jiuyi , Wang Furong , Liu Bo , Yin Biaolin 
Published: October 2016

AbstractPolysubstituted pyrroles and diastereoisomeric mixtures of spirolactams are obtained by reacting furfurylamines with ynones followed by oxidation with different amounts of CAN.
ChemInform Abstract: 2‐Diazo‐1‐phenyl‐2‐((trifluoromethyl)sulfonyl)ethan‐1‐one: Another Utility for Electrophilic Trifluoromethylthiolation Reactions.
Authors: Huang Zhongyan , Okuyama Kenta , Wang Chen , Tokunaga Etsuko , Li Xiaorui , Shibata Norio 
Published: October 2016

AbstractThe title diazo‐triflone (II) appears to be an effective electrophilic trifluoromethylthiolation reagent for a broad set of enamines, indoles, β‐keto esters, pyrroles and anilines under copper catalysis.
ChemInform Abstract: Nickel‐Catalyzed Hiyama‐Type Decarboxylative Coupling of Propiolic Acids and Organosilanes.
Authors: Raja Gabriel Charles Edwin , Irudayanathan Francis Mariaraj , Kim Han‐Sung , Kim Jimin , Lee Sunwoo 
Published: October 2016

AbstractThe reaction has a good functional group tolerance and is applicable to the transformation of but‐2‐ynedioic acid to symmetrical diarylalkynes.
ChemInform Abstract: Synthesis and Antimicrobial Evaluations of Novel Spiro Cyclic 2‐Oxindole Derivatives of N‐(1H‐Pyrazol‐5‐Yl)‐hexahydroquinoline Derivatives.
Authors: Abdelmoniem Amr Mohamed , Abdelshafy Abdelhamid Ismail , Soliman Ghozlan Said Ahmed , Ramadan Muhammed Ali 
Published: October 2016

AbstractMost of the prepared title spirocyclic compounds exhibit moderate to high antimicrobial activity.
ChemInform Abstract: One‐Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of β‐Carbolines and Other [c]‐Fused Pyridines.
Authors: Dhiman Seema , Mishra Uttam K. , Ramasastry S. S. V. 
Published: October 2016

AbstractA divergent strategy leads to the synthesis of di‐ and trisubstituted β‐carbolines through an unprecedented one‐pot triple‐orthogonal‐metal relay catalysis, and disubstituted hydroxy‐β‐carbolines through a one‐pot bimetallic relay catalysis from (aminophenyl)hexenynols.
Dynamic link sleeping reconfigurations for green traffic engineering
Authors: Okonor Obinna , Wang Ning , Georgoulas Stylianos , Sun Zhili 
Published: October 2016

SummaryThe high volume of energy consumption has become a great concern to the Internet community because of high energy waste on redundant network devices. One promising scheme for energy savings is to reconfigure network elements to sleep mode when traffic demand is low. However, due to the nature of today's traditional IP routing protocols, network reconfiguration is generally deemed to be harmful because of routing table reconvergence. To make these sleeping network elements, such as links, robust to traffic disruption, we propose a novel online scheme called designate to sleep algorithm that aims to remove network links without causing traffic disruption during energy‐saving periods. Considering the nature of diurnal traffic, there could be traffic surge in the network because of reduced network capacity. We therefore propose a complementary scheme called dynamic wake‐up algorithm that intelligently wakes up minimum number of sleeping links needed to control such dynamicity. This is contrary to the normal paradigm of either reverting to full topology and sacrificing energy savings or employing on‐the‐fly link weight manipulation. Using the real topologies of GEANT and Abilene networks respectively, we show that the proposed schemes can save a substantial amount of energy without affecting network performance.
Reduction Method of Fluctuation in Partial Discharge Inception Voltage for Inverter‐Fed Rectangular Wire Motors
Authors: WAKIMOTO TORU , KOJIMA HIROKI , HAYAKAWA NAOKI 
Published: October 2016

SUMMARYWe investigated the decisive factors that affect partial discharge inception voltage (PDIV) fluctuation between the coil wires under a sinusoidal voltage by using a rectangular wire motor. As a result, we found that PDIV under low humidity fluctuates by the surface charge, and PDIV under high humidity varies transitionally with the surface conductivity activated by predischarge. From these analyses, we proposed the measurement method of PDIV with a low fluctuation and transition for the rectangular wire motors, which will be optimized by environmental humidity, predischarge condition, and measuring frequency.
The application of GPR and ERI in combination with exposure logging and retrodeformation analysis to characterize sinkholes and reconstruct their impact on fluvial sedimentation
Authors: Zarroca Mario , Comas Xavier , Gutiérrez Francisco , Carbonel Domingo , Linares Rogelio , Roqué Carles , Mozafari Morteza , Guerrero Jesús , Pellicer Xavier M. 
Published: October 2016

AbstractThis work illustrates the practicality of investigating sinkholes integrating data gathered by ground penetrating radar (GPR), electrical resistivity imaging (ERI) and trenching or direct logging of the subsidence‐affected sediments in combination with retrodeformation analysis. This mutidisciplinary approach has been tested in a large paleosinkhole developed during the deposition of a Quaternary terrace on salt‐bearing evaporites. The subsidence structure, exposed in an artificial excavation, is located next to Puilatos, a village that was abandoned in the 1970s due to severe subsidence damage. Detailed logging of the exposure revealed that the subsidence structure corresponds to an asymmetric sagging and collapse paleosinkhole with no clear evidence of recent activity. The sedimentological and structural relationships together with the retrodeformation analysis indicate that synsedimentary subsidence controlled channel location, the development of a palustrine environment and local changes in the channel pattern. GPR profiles were acquired using an array of systems with different antenna frequencies, including some recently developed shielded antennas with improved vertical resolution and penetration depth. Although radargrams imaged the faulted sagging structure and provided valuable data on fault throw, they did not satisfactorily image the complex architecture of the fluvial deposit. ERI showed lower resolution but higher penetration depth when compared to GPR, roughly capturing the subsidence structure and yielding information on the thickness of the high‐resistivity alluvium and the nature of the underlying low‐resistivity karstic residue developed on top of the halite‐bearing evaporitic bedrock. Data comparison allows the assessment of the advantages and limitations of these complementary techniques, highly useful for site‐specific sinkhole risk management. Copyright © 2016 John Wiley & Sons, Ltd.
Öffentlich trauern
Authors: Benz Brigitte , Kranemann Benedikt 
Published: October 2016

AbstractDisaster Rituals: Gedenkfeiern nach Attentaten oder Katastrophen haben ihre eigene Dramaturgie. Je nach Ort, Ausgestaltung und Aussage höchst verschieden, sind sie direkt und indirekt mit Zeitgeist, Religionen und Weltanschauungen verbunden. Jetzt werden die neuen Formen des Innehaltens und Abschiednehmens auch Thema der liturgiewissenschaftlichen Forschung.
An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium
Authors: Curley Clive J. , Dolan Eimear B. , Cavanagh Brenton , O'Sullivan Janice , Duffy Garry P. , Murphy Bruce P. 
Published: October 2016

AbstractLocalized delivery of stem cells is potentially a promising therapeutic strategy for regenerating damaged myocardium. Many studies focus on limiting the biologic component of cell loss, but few address the contribution of mechanical factors. This study investigates optimal parameters for retaining the largest volume of cell loaded hydrogels post intramyocardial injection, without compromising cell viability. In vitro, hydrogel was injected into porcine hearts using various needle designs. Hydrogel retention and distribution pattern was then determined. The two most promising needles were then investigated to understand the effect of needle geometry on stem cell viability. The needle to best impact cell viability was then used to investigate the effect of differing hydrogels on retention and distribution. Three‐dimensional experimental modeling revealed needles with smaller diameter's to have greater poloxamer 407 hydrogel retention. No difference in retention existed among various needle designs of similar gauge, despite differences in bolus geometries. When hMSC's, embedded in fibrin hydrogel, were injected through helical and 26G bevel needles no difference in the percent of live cells was seen at 48 h. However, the helical group had almost half the metabolic activity of the 26G bevel group at both time points, and had a significant decline in the percent of live cells from 24 to 48 h. Varying gel type resulted in significantly more alginate being retained in the tissue in comparison to fibrin or poloxamer hydrogels. In conclusion, mechanical properties of injected hydrogels, and the diameter of the needle used, highly influences the volume of hydrogel retained. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2618–2629, 2017.