bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elaboration of a triphasic calcium phosphate and silica nanocomposite for maxillary grafting and deposition on titanium implants
Authors: Camargo Nelson Heriberto Almeida , Gemelli Enori , Passoni Laís Schmitz , Franczak Priscila Ferraz , Corrêa Pricyla 
Published: January 2018

Abstract
A hydroxyapatite and tricalcium phosphate nanocomposite containing 5% silica was developed for dental applications. The biomaterial was prepared by one-step synthesis via the wet route. The resulting dry material consisted of hydrated calcium phosphate agglomerates with sizes of up to 200 μm. The presence of silica was found to lower the phase transformation temperature of the calcium phosphates and increase the open porosity of the biomaterial compared to that of hydroxyapatite. The hydrated calcium phosphate transformed into hydroxyapatite (HA) and beta tricalcium phosphate (TCP) at approximately 682 °C. After 2 h of calcination at 900 °C, the volume ratios of HA and TCP in the nanocomposite were 84 and 16%, respectively. The open porosity in the triphasic nanocomposite and in the HA was 46.35% and 41.52%, respectively, after 3 h of sintering at 1 100 °C. Samples of grade 2 titanium were sandpapered and etched with an acid solution of HCl/H2SO4 prior to deposition of the calcined nanocomposite. The particles were deposited homogeneously and reduced the contact angle of the titanium surface.
Capturing complexity in clinician case-mix: classification system development using GP and physician associate data
Authors: Halter Mary , Joly Louise , de Lusignan Simon , Grant Robert L , Gage Heather , Drennan Vari M 
Published: January 2018

BackgroundThere are limited case-mix classification systems for primary care settings which are applicable when considering the optimal clinical skill mix to provide services.AimTo develop a case-mix classification system (CMCS) and test its impact on analyses of patient outcomes by clinician type, using example data from physician associates’ (PAs) and GPs' consultations with same-day appointment patients.Design & settingSecondary analysis of controlled observational data from six general practices employing PAs and six matched practices not employing PAs in England.MethodRoutinely-collected patient consultation records (PA n = 932, GP n = 1154) were used to design the CMCS (combining problem codes, disease register data, and free text); to describe the case-mix; and to assess impact of statistical adjustment for the CMCS on comparison of outcomes of consultations with PAs and with GPs.ResultsA CMCS was developed by extending a system that only classified 18.6% (213/1147) of the presenting problems in this study's data. The CMCS differentiated the presenting patient’s level of need or complexity as: acute, chronic, minor problem or symptom, prevention, or process of care, applied hierarchically. Combination of patient and consultation-level measures resulted in a higher classification of acuity and complexity for 639 (30.6%) of patient cases in this sample than if using consultation level alone. The CMCS was a key adjustment in modelling the study’s main outcome measure, that is rate of repeat consultation.ConclusionThis CMCS assisted in classifying the differences in case-mix between professions, thereby allowing fairer assessment of the potential for role substitution and task shifting in primary care, but it requires further validation.
A small-scale study on airborne transmission of H9N2 avian influenza virus under field conditions
Authors: Li Song , Zhou Yufa , Gao Shujuan , Pang Quanhai , Miao Zengmin 
Published: January 2018

Introduction: H9N2 avian influenza viruses (AIV) can transmit in chicken flocks through direct contact and aerosols. Nevertheless, data on airborne transmission of AIV is very limited, especially under field conditions. To fill this literature gap, this study was designed to investigate airborne transmission of H9N2 AIV originating from infected chicken flocks under field conditions, with the aim to further characterize the airborne transmission of H9N2 AIV.
Methodology: Oropharyngeal swabs were collected from different diseased chickens to confirm H9N2 AIV infection. All glass impingers 30 (AGI-30) were used to collect indoor, upwind and downwind air samples for three chicken houses with H9N2 AIV infected chickens. Swabs and air samples were tested for H9N2 AIV using a real-time reverse transcription polymerase chain reaction (RRT-PCR). H9N2 AIV was isolated in embryonated chicken eggs and hemagglutinin (HA) gene sequence similarity of the isolated AIV was compared.
Results: The results showed that indoor air samples were all RRT-PCR positive for H9N2 AIV. Downwind air samples collected between 10 m and 1.5 km away from the chicken houses were also found positive with an average load 2.62-5.21×103 RNA copies/m3. However, upwind air samples were all negative for H9N2 AIV. In addition, H9N2 AIV was isolated from swabs and indoor air samples.
Conclusion: In summary, this study provides insights into the airborne transmission of H9N2 AIV under field conditions.
Factors Determining Nephrotoxicity and Mortality in Critical Care Patients Receiving Colistin
Authors: Ciftci Ali , Izdes Seval , Altintas Neriman Defne 
Published: January 2018

Introduction: We aimed to determine risk factors for nephrotoxicity and factors affecting mortality in patients who received colistin.
Methodology: Critical patients who received colistin were enrolled. Pregnancy, age < 18 years, basal creatinine level > 2 mg/dL, colistin use for < 48 hours, and previous renal replacement therapy were exclusion criteria. KDIGO stages were determined according to creatinine levels. Patients were grouped as those with no acute kidney injury (Group N0) and those with acute kidney injury (Group N). Their demographic data, APACHE II and SOFA scores, treatments, and laboratory results were recorded.
Results: A total of 91 patients were included: 27 in Group N0 and 64 in Group N. Demographic data were similar between groups; however, higher admission APACHE-II scores (OR:1.179, 95% CI:1.033-1.346, p = 0.015) and need for vasopressors (OR:5.486, 95% CI:1.522–19.769, p = 0.009) were found to be independent risk factors for nephrotoxicity. Higher APACHE II scores (OR:1.253, %95 CI:1.093-1.437, p = 0.001), presence of coronary artery disease (OR:7.720, % 95 CI: 1.613-36.956, p = 0.011), need for vasopressors (OR: 4.587, % 95 CI: 1.224 – 17.241, p = 0.024), hypoalbuminemia (OR: 4.721, % 95 CI: 1.088 – 20.469, p = 0.038), and higher direct bilirubin levels (OR: 1.806, % 95 CI: 1.055 – 3.092, p = 0.031) were independent risk factors for mortality.
Conclusion: When use of colistin is considered in ICU patients, presence of modifiable risk factors for nephrotoxicity such as hypoalbuminemia, nephrotoxic drug administration, and presence of shock should be determined and managed to prevent nephrotoxicity.
Molecular characterization of resistance mechanisms in Pseudomonas aeruginosa isolates resistant to carbapenems
Authors: Shaaban Mona , Al-Qahtani Ahmed , Al-Ahdal Mohammed , Barwa Rasha 
Published: January 2018

Introduction: Emergence of carbapenem resistance in Pseudomonas aeruginosa increases the therapeutic dilemma. In this study, we investigated various mechanisms involved in the resistance of P. aeruginosa clinical isolates to carbapenems.
Methodology: P. aeruginosa isolates were isolated from different clinical samples. The antimicrobial susceptibility was evaluated by disc diffusion method. Carbapenemases were detected among carbapenem resistant isolates. Expression level of mexB and oprD was determined by real-time PCR. Molecular relatedness among isolates was detected based on pulse-field gel electrophoresis (PFGE).
Results: Ninety P. aeruginosa isolates were purified from clinical specimens. High levels of resistance to imipenem and meropenem were detected in 16 isolates. PCR analysis of carbapenemases indicated the prevalence of Verona integron-encoded metallo-beta-lactamase (VIM); four isolates produced only VIM enzymes (VIM-1 or VIM-2), while the remaining twelve co-produced both VIM-1 or VIM-2 and NDM enzymes.
Additionally, real-time PCR analysis elucidated high expression levels of mexB in seven of the carbapenem resistant isolates and low expression of oprD in seven isolates.
The identified carbapenem-resistant isolates were clustered into eleven PFGE profiles where clusters E1 and E2 involved isolates exhibiting multiple carbapenemase genes (blaNDM-1, blaVIM-1 and blaVIM-2).
Conclusion: Various mechanisms underlying carbapenem resistance have been detected in our P. aeruginosa cohort of isolates. Emergence of P. aeruginosa as a reservoir of multiple carbapenemases is increasing over time limiting the treatment options to this serious infection. This increases the urgency for infection control practices to reduce the incidence of this infection.
Évolutions et transformations des financements publics des associations
Authors: Prouteau Lionel , Tchernonog Viviane 
Published: January 2018

Les enquêtes périodiques intitulées « Paysage associatif » conduites par le Centre d’économie de la Sorbonne analysent les transformations intervenues en matière de financement du secteur associatif. Elles montrent une privatisation croissante des ressources de ce secteur qui demande une participation financière des usagers au service rendu, voit augmenter du poids des conseils départementaux et se transformer les modalités du financement public avec la baisse des subventions et l’explosion des commandes publiques. Ces transformations impactent le développement du secteur en développant son rôle d’instrument de mise en œuvre des politiques sociales et en sélectionnant les objectifs de ces politiques en fonction de la solvabilité de leurs publics. Enfin, elles accélèrent les inégalités de développement des tissus associatifs locaux désormais largement tributaires des capacités locales de financement.
L’être-ange et l’être-d’ailleurs dans le groupe
Authors: Navridis Klimis 
Published: January 2018

L’Ange provenant du mot grec Angélos qui veut dire messager porte en lui les sources de l’ambivalence : curieux messager ayant pris dans la culture picturale du christianisme la forme énigmatique de cet éternel enfant tout rose et dodu innocent et asexuel l’Ange est devenu le symbole quasiment universel de l’amour Par ailleurs l’« être-Ange » dans un groupe figure de l’étrange et de l’étrangeté diabolisé ou idéalisé représente toujours une « lettre d’ailleurs » Ce message indicible cette « lettre » inscrite dans le groupe mais étant à la fois adressée au groupe et « écrite » par le groupe serait porteuse de messages pluriels et parfois contradictoires : messages inquiétants voire terrifiants mais aussi prometteurs et optimistes À partir d’un exemple clinique de psychothérapie psychanalytique de groupe cet article propose l’esquisse d’une problématique concernant l’apparition et le traitement analytique en groupe des phénomènes soi-disant d’« angélisation »
Le parcours précurseur de Jean Claude Rouchy. Réflexions et souvenirs sur l’enseignement du transfert dans le groupe
Authors: Darchis Élisabeth 
Published: January 2018

Le parcours de Jean Claude Rouchy témoigne de l’histoire du mouvement de la psychanalyse de groupe. Rouchy s’est appuyé sur ses expériences groupales institutionnelles et associatives pour analyser les processus groupaux, notamment le transfert dans le groupe. L’espace créé dans les groupes, thérapeutiques ou de formation, permet le travail analytique sur deux types de transferts, déjà distingués par Freud : les rééditions qui répètent dans le groupe un scénario dans « du même » sans avoir conscience de remettre en scène la même chose et les éditions corrigées où il y a une distance avec ce qui se répète « dans l’identique », mais pas dans tout à fait du même. Dans les processus de groupe se déplacent transférentiellement non seulement la relation à un parent ou des séries de relations duelles, mais aussi des liens primaires et des groupes internes en rapport au groupe familial d’origine.
A Multisite Survey Study of EMR Review Habits, Information Needs, and Display Preferences among Medical ICU Clinicians Evaluating New Patients
Authors: Nolan Matthew , Cartin-Ceba Rodrigo , Moreno-Franco Pablo , Pickering Brian , Herasevich Vitaly 
Published: January 2018

Objective The electronic chart review habits of intensive care unit (ICU) clinicians admitting new patients are largely unknown but necessary to inform the design of existing and future critical care information systems.
Methods We conducted a survey study to assess the electronic chart review practices, information needs, workflow, and data display preferences among medical ICU clinicians admitting new patients. We surveyed rotating residents, critical care fellows, advanced practice providers, and attending physicians at three Mayo Clinic sites (Minnesota, Florida, and Arizona) via email with a single follow-up reminder message.
Results Of 234 clinicians invited, 156 completed the full survey (67% response rate). Ninety-two percent of medical ICU clinicians performed electronic chart review for the majority of new patients. Clinicians estimated spending a median (interquartile range (IQR)) of 15 (10–20) minutes for a typical case, and 25 (15–40) minutes for complex cases, with no difference across training levels. Chart review spans 3 or more years for two-thirds of clinicians, with the most relevant categories being imaging, laboratory studies, diagnostic studies, microbiology reports, and clinical notes, although most time is spent reviewing notes. Most clinicians (77%) worry about overlooking important information due to the volume of data (74%) and inadequate display/organization (63%). Potential solutions are chronologic ordering of disparate data types, color coding, and explicit data filtering techniques. The ability to dynamically customize information display for different users and varying clinical scenarios is paramount.
Conclusion Electronic chart review of historical data is an important, prevalent, and potentially time-consuming activity among medical ICU clinicians who would benefit from improved information display systems.
Segmentación de mallas 3d de edificios históricos para levantamiento arquitectónico
Authors: Herráez Borja Javier , Vendrell Eduardo 
Published: January 2018

<p>Advances in three-dimensional (3D) acquisition systems have introduced this technology to more fields of study, such as archaeology or architecture. In the architectural field, scanning a building is one of the first possible steps from which a 3D model can be obtained and can be later used for visualisation and/or feature analysis, thanks to computer-based pattern recognition tools. The automation of these tools allows for temporal savings and has become a strong aid for professionals, so that more and more methods are developed with this objective. In this article, a method for 3D mesh segmentation focused on the representation of historic buildings is proposed. This type of buildings is characterised by having singularities and features in façades, such as doors or windows. The main objective is to recognise these features, understanding them as those parts of the model that differ from the main structure of the building. The idea is to use a recognition algorithm for planar faces that allows users to create a graph showing the connectivity between them, therefore allowing the reflection of the shape of the 3Dmodel. At a later step, this graph is matched against some pre-defined graphs that represent the patterns to look for. Each coincidence between both graphs indicate the position of one of the characteristics sought. The developed method has proved to be effective for feature detection and suitable for inclusion in architectural surveying applications.</p>
Competência em Informação: perspectiva didática pedagógica
Authors: Farias Gabriela Belmont de , Belluzzo Regina Célia Baptista 
Published: January 2018

Apresenta reflexão sobre as ações de ensino aprendizagem que podem influenciar positivamente na formação dos discentes do curso de Biblioteconomia no contexto brasileiro, ao apropriar-se da “Modelagem Pedagógica de Desenvolvimento da Competência em Informação”, colocando-a em prática por meio de intervenções pedagógicas. O objetivo foi elaborar o modelo supracitado tendo como base a normativa da The Association of College and Research Libraries que consideram que a competência em informação é comum a todas as disciplinas, a todos os contextos de aprendizagem e a todos os níveis de ensino. A pesquisa configura-se por uma abordagem qualitativa de natureza bibliográfica e exploratória. Trata-se de uma contribuição de aspecto inovador e social aos interessados na adoção de novas posturas nesta ambiência de ensino-aprendizagem, além de auxiliar na compreensão das questões fundamentais relacionadas à competência em informação, possibilitando a sua apropriação junto aos cursos de Biblioteconomia e promovendo o aprofundamento das reflexões ora apontadas e a necessidade de implementá-la como parte da formação básica do bibliotecário.
Comparison of Diabetic Foot Care with Other Diabetic Preventive Care Services
Authors: Jadali Fayegh , Nemati Hamid , Jadali Piran , Jadali Patrick 
Published: January 2018

Background:
Diabetes is a major chronic disease with high morbidity and mortality. Diabetic preventive care services are essential in the management and outcome of the disease. More than other preventive diabetic care services, preventive care of diabetic retinopathy has been emphasized and recommended by practitioners and insurance companies. We investigated the status of preventive care in the diabetic population.

Methods:
Information was collected from 420 outpatients aged 30 to 80 years. The patients were divided into two groups: those with well-controlled blood sugar levels (hemoglobin A1c [HbA1c] level ≤7%) and those with uncontrolled blood sugar levels (HbA1c level &gt;7%).

Results:
Data analysis indicated that for both groups, 93% of the participants were seen for diabetic eye care at least once and 78% were getting an annual eye examination regularly. In the controlled and uncontrolled blood sugar groups, 26% and 32% of patients, respectively, had ever seen a nephrologist and 38% and 49%, respectively, had ever seen a cardiologist. In the controlled and uncontrolled blood sugar groups, 32% and 38% of patients, respectively, had visited a podiatric physician. For statistical analysis and comparison of results between the two groups, we applied the χ2 test and calculated 95% confidence intervals. There were some significant differences regarding the complications of diabetes mellitus and preventive care.

Conclusions:
There is a need for greater engagement by podiatric physicians and health-care providers to promote regular visits for the diabetic population to podiatric medical clinics.
A Perforated Gastric Carcinoma: A Single-Center Experience
Authors: Baykan Mehmet , Arikan Turkmen Bahadır , Donder Yunus , Sözüer Erdoğan , Akyildiz Hızır Yakup 
Published: January 2018

ObjectiveIn this study, we aimed to describe clinicopathologic characteristics of the patients with a perforated gastric carcinoma, and to assess surgical approaches and possible factors affecting mortality and morbidity.Material and MethodWe retrospectively reviewed data of 18 patients who underwent emergent surgery for a perforated gastric carcinoma between January 2002 and December 2012. Data including surgical procedure, pathologic findings, complications, morbidity and mortality rates, and outcomes were evaluated.ResultsThe mean age was 58 years. The most common tumor localization was antrum (55%), and 11 patients (61.1%) had Stage IV disease. Nine patients (50%) had a comorbid disease. Of the patients, primary suture + omentopexy was performed in 11 (61.1%) whereas total gastrectomy with D0 or D1 lymph node dissection in 5 (27.7%), subtotal gastrectomy with D0 lymph node dissection in 2 (11.1%), and 2-stage total gastrectomy with D2 lymph node dissection in 2 (11.1%). The complication rate was 50% with a mortality rate of 50%. Overall survival was 79 ± 97.89 days. Sepsis and the presence of comorbidities were found to increase early mortality (P = 0.00 and P = 0.028)ConclusionOur study results show that postoperative morbidity and mortality rates are still high in patients with a perforated gastric carcinoma. In stable patients, 1-step radical gastrectomy should be performed, while palliative surgery or 2-stage radical gastrectomy can be performed in patients with poor overall status and diffuse peritonitis. Early diagnosis and perforation management before the onset of diffuse peritonitis can decrease high mortality and morbidity rates.
Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a
Authors: Kim Taek‐Keun , Park Chang Sik , Jang Jihye , Kim Mi Ra , Na Hee‐Jun , Lee Kangseung , Kim Hyun Jung , Heo Kyun , Yoo Byong Chul , Kim Young‐Myeong , Lee Je‐Wook , Kim Su Jin , Kim Eun Sung , Kim Dae Young , Cha Kiweon , Lee Tae Gyu , Lee Sukmook 
Published: January 2018

The C‐type lectin‐like domain of CLEC14a (CLEC14a‐C‐type lectin‐like domain [CTLD]) is a key domain that mediates endothelial cell–cell contacts in angiogenesis. However, the role of CLEC14a‐CTLD in pathological angiogenesis has not yet been clearly elucidated. In this study, through complementarity‐determining region grafting, consecutive deglycosylation, and functional isolation, we generated a novel anti‐angiogenic human monoclonal antibody that specifically targets CLEC14a‐CTLD and that shows improved stability and homogeneity relative to the parental antibody. We found that this antibody directly inhibits CLEC14a‐CTLD‐mediated endothelial cell–cell contact and simultaneously downregulates expression of CLEC14a on the surface of endothelial cells. Using various in vitro and in vivo functional assays, we demonstrated that this antibody effectively suppresses vascular endothelial growth factor (VEGF)‐dependent angiogenesis and tumor angiogenesis of SNU182 human hepatocellular carcinoma, CFPAC‐1 human pancreatic cancer, and U87 human glioma cells. Furthermore, we also found that this antibody significantly inhibits tumor angiogenesis of HCT116 and bevacizumab‐adapted HCT116 human colorectal cancer cells. These findings suggest that antibody targeting of CLEC14a‐CTLD has the potential to suppress VEGF‐dependent angiogenesis and tumor angiogenesis and that CLEC14a‐CTLD may be a novel anti‐angiogenic target for VEGF‐dependent angiogenesis and tumor angiogenesis.
Control of ULF Wave Accessibility to the Inner Magnetosphere by the Convection of Plasma Density
Authors: Degeling A. W. , Rae I. J. , Watt C. E. J. , Shi Q. Q. , Rankin R. , Zong Q.‐G. 
Published: January 2018

AbstractDuring periods of storm activity and enhanced convection, the plasma density in the afternoon sector of the magnetosphere is highly dynamic due to the development of plasmaspheric drainage plume (PDP) structure. This significantly affects the local Alfvén speed and alters the propagation of ULF waves launched from the magnetopause. Therefore, it can be expected that the accessibility of ULF wave power for radiation belt energization is sensitively dependent on the recent history of magnetospheric convection and the stage of development of the PDP. This is investigated using a 3‐D model for ULF waves within the magnetosphere in which the plasma density distribution is evolved using an advection model for cold plasma, driven by a (VollandStern) convection electrostatic field (resulting in PDP structure). The wave model includes magnetic field day/night asymmetry and extends to a paraboloid dayside magnetopause, from which ULF waves are launched at various stages during the PDP development. We find that the plume structure significantly alters the field line resonance location, and the turning point for MHD fast waves, introducing strong asymmetry in the ULF wave distribution across the noon meridian. Moreover, the density enhancement within the PDP creates a waveguide or local cavity for MHD fast waves, such that eigenmodes formed allow the penetration of ULF wave power to much lower L within the plume than outside, providing an avenue for electron energization.