bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reaction of Triarylchloroallenes with Nucleophiles Under Solvolytic Conditions.
Authors: KITAMURA T. , MIYAKE S. , KOBAYASHI S. , TANIGUCHI H. 
Published: May 2016

AbstractThe title reaction of (I) in the presence of the nucleophiles (II), (IV) and (VI) gives the products shown in the scheme.
ChemInform Abstract: 3,5‐Diphenyl‐1H‐pyrazole Derivatives. Part 2. N‐Substituted 1‐(2‐Aminoethyl)‐3,5‐diphenyl‐1H‐pyrazoles and Their 4‐Bromo Derivatives with Analgesic and Other Activities.
Authors: BONDAVALLI F. , BRUNO O. , RANISE A. , SCHENONE P. , RUSSO S. , LOFFREDA A. , DE NOVELLIS V. , LO SASSO C. , MARMO E. 
Published: May 2016

AbstractThe diphenyl pyrazoles (I) are transformed into the tosylates (III).
ChemInform Abstract: A Novel Route to Optically Active Dihydropyrans and 3‐Methylenetetrahydrofurans.
Authors: AL‐DULAYYMI J. , BAIRD M. S. 
Published: May 2016

AbstractSeveral rearrangement processes of the 2‐hydroxyalkylcyclopropenes (III), (VI), or (IX) are described.
ChemInform Abstract: Cardiotonic Agents. Part 9. Synthesis and Biological Evaluation of a Series of E‐4,5‐Dihydro‐6‐(2‐(4‐(1H‐imidazol‐1‐yl)phenyl)ethenyl)‐3(2H)‐pyridazinones: A Novel Class of Compounds with Positive Inotropic, Antithrombic, and Vasodilatory Activities for the Treatment of Congestive Heart Failure.
Authors: SIRCAR I. , STEFFEN R. P. , BOBOWSKI G. , BURKE S. E. , NEWTON R. S. , WEISHAAR R. E. , BRISTOL J. A. , EVANS D. B. 
Published: May 2016

AbstractThe p‐azolylbenzaldehydes (I) are coupled with the substituted levulinic acids (II) to give the unsaturated keto acids (III) which are cyclized with hydrazine hydrochloride (IV), forming the pyridazinones (V).
ChemInform Abstract: Some 3‐Heterofunctional Derivatives of Imidazo(2,1‐f)xanthines.
Authors: GARMASH S. N. , PRIIMENKO B. A. , SKUL'SKAYA E. A. , KLYUEV N. A. 
Published: May 2016

AbstractStarting with the imidazoxanthines (I), the derivatives (III), (V), (VI), and (VIII) are prepared by common methods.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Pyrrole Derivatives. Part 3. 2‐(4‐Arylpiperazino)‐3‐ethoxycarbonyl‐5‐arylpyrrole Derivatives.
Authors: COCCO M. T. , CONGIU C. , MACCIONI A. , SCHIVO M. L. , DE LOGU A. , PALMIERI G. 
Published: May 2016

AbstractThe ethoxyaminoacrylate (I) is coupled with the piperazines (II) to give the amidines (III) which undergo cyclocondensation with the bromoacetophenones (IV), yielding the pyrroles (V).
ChemInform Abstract: Preparation of Hindered Styrenes and Arylacetylenes.
Authors: GARST M. E. , MCBRIDE B. J. 
Published: May 2016

AbstractThe substituted trimethoxyphenyl iodides (I) are coupled with the vinylsilane (II) or the ethynylsilane (IV) in the presence of a Pd(II) phosphine catalyst, yielding the silylstyrenes (III) and the arylsilylacetylenes (V) respectively.
ChemInform Abstract: Ring Opening of Diphosphiranes Leading to 1,3‐Diphosphaallene.
Authors: GOUYGOU M. , TACHON C. , EL OUATIB R. , RAMARIJAONA O. , ETEMAD‐MOGHADAM G. , KOENIG M. 
Published: May 2016

AbstractThe diphosphiranes (I) are photolyzed to form the diphosphapropenes (II) which react with methyllithium under dehalogenation to give the diphosphaallene (III).
ChemInform Abstract: Synthesis, Optical, Photophysical, and Redox Properties of a Ligand‐Bridged Heteronuclear (OC)5W(pyz)Re(CO)4Cl (pyz: Pyrazine) Complex.
Authors: ZULU M. M. , LEES A. J. 
Published: May 2016

AbstractThe title complex (III) is prepared according to the scheme.
ChemInform Abstract: Reactivity of Cyclopalladated Compounds. Part 20. Isolation of a Bis(η4‐arene)dipalladium(I) Complex During the Annelation of Palladated Aryl Groups with Diphenylacetylene.
Authors: DUPONT J. , PFEFFER M. , ROTTEVEEL M. A. , DE CIAN A. , FISCHER J. 
Published: May 2016

AbstractThe chloride‐bridged dimer (I) (synthesized through classical palladation of the corresponding ligands using Pd acetate followed by anion metathesis with LiCl) is converted in situ into the cationic species (III).
ChemInform Abstract: Facile Aerial Oxidation of a Porphyrin. Part 4. Unsymmetrical meso‐Tetra‐Aryl Porphyrins with 3,5‐Di‐tert.‐butyl‐4‐hydroxyphenyl and 4‐Hydroxyphenyl Substituents.
Authors: MILGROM L. R. , MOFIDI N. , JONES C. C. , HARRIMAN A. 
Published: May 2016

AbstractIn methanolic KOH, the title compounds (IVb)‐(IVe) (yields given in mg; 1H NMR data, UV/VIS and ESR spectra) undergo irreversible aerial oxidation, which is slower and less extensive than that of the known parent compound (IVa).
ChemInform Abstract: Icosahedral Shell Structure in Metal‐Doped Rare Gas Clusters.
Authors: SCHRIVER K. E. , HAHN M. Y. , PERSSON J. L. , LAVILLA M. E. , WHETTEN R. L. 
Published: May 2016

AbstractA molecular beam source of metal atom‐doped inert gas clusters is developed and time‐of‐flight mass spectra are reported for AlArn clusters (n = 1‐200) generated using this source.
ChemInform Abstract: X‐Ray Powder Structure and Rietveld Refinement of the Monosodium‐Exchanged Monohydrate of α‐Zirconium Phosphate, Zr(NaPO4)(HPO4)·H2O.
Authors: RUDOLF P. R. , CLEARFIELD A. 
Published: May 2016

AbstractThe title compound crystallizes in space group P21/c with Z=4.
ChemInform Abstract: Importance of the Anatase‐Rutile Phase Transition and Titania Grain Enlargement in the Strong Metal‐Support Interaction (SMSI) Phenomenon in Fe/TiO2 Catalysts.
Authors: NOBILE A. JUN. , DAVIS M. W. JUN. 
Published: May 2016

AbstractIt is found, that in the catalyst system consisting of iron supported on high‐surface‐area titania powder anatase‐rutile phase transition, titania grain enlargement, and the SMSI effect occur simultaneously at reduction temp. above 723 K. The three phenomena are proposed to be interrelated whereby Ti3+ defect centers in the titania lattice formed by reduction are responsible for acceleration of the phase transition and grain enlargement.
ChemInform Abstract: Synthesis and Characterization of the New Mixed Oxides M2(GeTe)O6 (M: K, Rb, Cs).
Authors: AMARILLA M. , VEIGA M. L. , PICO C. , GAITAN M. , JEREZ A. 
Published: May 2016

AbstractThe title compounds are prepared by solid state reaction of Te(OH)6, GeO2, and MNO3 (M: K, Rb, Cs) (porcelain crucibles, 673 K, 36 h; 873 K, 24 h).
ChemInform Abstract: Selective Allylic Electron‐Transfer Oxidation of β‐Ionone.
Authors: CALO V. , LOPEZ L. , TROISI L. 
Published: May 2016

AbstractOxidation of β‐ionone (I) with a cation radical oxidizing‐agent in the presence of water or alcohols (III) leads to the formation of the allylic alcohol and ethers (III).
ChemInform Abstract: Formation of 7,7′‐Biindolyls by Oxidative Dimerization of 4,6‐Dimethoxy‐2,3‐diphenylindole.
Authors: BLACK D. ST. C. , CHOY A. , CRAIG D. C. , IVORY A. J. , KUMAR N. 
Published: May 2016

AbstractOxidation of 4,6‐dimethoxy‐2,3‐diphenylindole (I) with 1,4‐benzoquinone or chloranil results in dimerization, producing the 7,7‐biindolyl (II).
ChemInform Abstract: Quaternary Salts of 2‐((Hydroxyimino)methyl)imidazole. Part 3. Synthesis and Evaluation of (Alkenyloxy)‐, (Alkynyloxy)‐, and (Aralkyloxy)methyl Quaternized 2‐((Hydroxyimino)methyl)‐1‐alkylimidazolium Halides as Reactivators and Therapy for Soman Intoxication.
Authors: BEDFORD C. D. , HARRIS R. N. III , HOWD R. A. , GOFF D. A. , KOOLPE G. A. , PETESCH M. , KOPLOVITZ I. , SULTAN W. E. , MUSALLAM H. A. 
Published: May 2016

AbstractForty‐six imidazolium halides such as (V) are prepared by reaction of the imidazole (IV) with chloromethyl ethers such as (III) which are obtained from the corresponding alcohols (I) and trioxane (II) in the presence of HCl.
ChemInform Abstract: Carbon‐Hydrogen Bond Activation in Novel η2‐Bound Cationic Heterocycle Complexes of Pentaammineosmium(II).
Authors: CORDONE R. , HARMAN W. D. , TAUBE H. 
Published: May 2016

AbstractReduction of the Os complex (I) with cobaltocene in the presence of cationic pyridines such as (II) leads to formation of the isolable π‐complex (III).
ChemInform Abstract: Vacuum‐Ultraviolet Spectroscopy of Group V Oxides: P4O6 and As4O6.
Authors: ROSE J. L. , VANCOTT T. C. , SCHATZ P. N. , BOYLE M. E. , PALMER M. H. 
Published: May 2016

AbstractFor the first time vacuum UV and MCD spectra are reported for P4O6 and As4O6 isolated in argon matrices.
ChemInform Abstract: Effect of Dissolved Electron Acceptors and Platinum Loading on the Luminescence of CdS Powder in Aqueous Solutions.
Authors: UCHIHARA T. , MATSUMURA M. , TSUBOMURA H. 
Published: May 2016

AbstractIn the case of CdS powders in aqueous solution, the intensity of the green emission (510 nm) is not affected by the addition of electron donors such as SO32‐ and (Fe(CN)6)4‐ but is significantly lowered by addition of electron acceptors such as methylviologen and (Fe(CN)6)3‐ as well as by loading with Pt.
ChemInform Abstract: Studies of the n‐GaAs/KOH‐Se2‐ 2‐Se2‐ Semiconductor/Liquid Junction.
Authors: TUFTS B. J. , ABRAHAMS I. L. , CASAGRANDE L. G. , LEWIS N. S. 
Published: May 2016

AbstractThe I‐V characteristics of the semiconductor/liquid junction of title are determined for a variety of conditions, including changes in the majority carrier density, the minority carrier diffusion length, and the incident light intensity.
ChemInform Abstract: Hydration of Nitriles to Amides Promoted by Mercury(II) Acetate in Acetic Acid.
Authors: PLUMMER B. F. , MENENDEZ M. , SONGSTER M. 
Published: May 2016

AbstractThe nitriles (I) are converted into the carboxylic amides (II) by treatment with mercury(II) acetate in boiling acetic acid in the presence of water.
ChemInform Abstract: Electron‐Deficient Isoxazoles: 1,3‐Dipolar Cycloadditions of Ethyl 4‐Nitro‐3‐phenylisoxazole‐5‐carboxylate with Diazoalkanes.
Authors: NESI R. , GIOMI D. , PAPALEO S. , BRACCI S. , DAPPORTO P. 
Published: May 2016

Abstract1,3‐Dipolar cycloaddition of the title compound (I) with equimolar amounts of diazomethane (II) produces the oxazabicyclo(3.1.0)hexene derivative (IV), obtained via the intermediate adduct (III) by elimination of nitrogen, and the isoxazole derivative (V); 40% of the starting material (I) are recovered.
ChemInform Abstract: Synthesis of 1‐Alkyl‐1,2,4‐triazoles: A New One‐Pot Regiospecific Procedure.
Authors: ASTLEFORD B. A. , GOE G. L. , KEAY J. G. , SCRIVEN E. F. V. 
Published: May 2016

AbstractAlkylation of 4‐amino‐1,2,4‐triazole (I) with the alkyl halides (II) produces regioselectively the 1‐alkyl‐4‐amino‐1,2,4‐triazolium salts (III) which are converted into the title compounds (IV) by deamination with sodium nitrite/hydrochloric acid.
ChemInform Abstract: Substituent‐Directing Effects in the Homolytic Acylation of Pyrazine Derivatives.
Authors: HOUMINER Y. , SOUTHWICK E. W. , WILLIAMS D. L. 
Published: May 2016

AbstractHomolytic acylation of the methoxy‐ or chloro‐substituted pyrazines (I) with the aldehydes (II) in the presence of tert‐butyl hydroperoxide and ferrous sulfate produces the 2,3‐disubstituted pyrazines (III), whereas acylation of the acetyl, carbethoxy, and carboxamido derivatives (IV) with (II) leads to the formation of the 2,5‐disubstituted pyrazines (V).
ChemInform Abstract: Boron‐Stabilized N,O‐Carbenes. Part 1. Triphenylboron Adducts of Siloxy‐ and Hydroxyalkyl Isocyanides and Spontaneous Formation of Ate‐Ylids.
Authors: FEHLHAMMER W. P. , HOFFMEISTER H. , STOLZENBERG H. , BOYADJIEV B. 
Published: May 2016

AbstractThe adducts (III) of triphenylboron (II) and 2‐ and 3‐hydroxyalkyl isocyanides (I) spontaneously undergo intramolecular cyclization to give the compounds (IV).
ChemInform Abstract: Synthesis of Symmetrical and Unsymmetrical Aminophosphites.
Authors: STAMATOV S. D. , IVANOV S. A. 
Published: May 2016

AbstractActivation of the triaminophosphane (I) with iodine and subsequent addition of the alcohols (II) yield the phosphorus derivatives (III) which are oxidized in situ by sulfur to give the bisamidothiophosphates (IV).
ChemInform Abstract: Diphos‐Dithiophosphate‐Carboxylate Variations on the Mo2S6+ 2 Core.
Authors: LIZANO A. C. , RICHARDSON J. F. , NOBLE M. E. 
Published: May 2016

AbstractThe carboxylate‐bridged diphosphine(dithiophosphato)‐Mo2 complexes (IV) are obtained by reaction of the tetramer (I) with three equiv. of the diphosphine (II) and the carboxylic acid (III) as shown.
ChemInform Abstract: Thiolato‐Technetium Complexes. Part 3. Synthesis and X‐Ray Structural Studies on the Geometrical Isomers cis‐ and trans‐Bis(p‐chlorobenzenethiolato)bis(1,2‐bis(dimethylphosphino)ethane)technetium(II).
Authors: KONNO T. , HEEG M. J. , DEUTSCH E. 
Published: May 2016

AbstractThe air‐stable geometric isomers (III) and (IV) of the title complex are obtained according to the scheme and characterized by X‐ray structure analysis (cis isomer (III): space group Iba2, Z=4; trans isomer (IV): P21/c, Z=2).
ChemInform Abstract: Transition‐Metal Silyl Complexes. Part 29. Formation of Dihydride Complexes from Hydrido(silyl)tetracarbonyliron Derivatives.
Authors: SCHUBERT U. , KNORR M. 
Published: May 2016

AbstractThe attempted CO/phosphine exchange reaction of the hydrido(silyl)tetracarbonyl‐Fe complexes (I) with the diphosphine (II) results in the unexpected formation of the dihydride complex (III).
ChemInform Abstract: Chemistry of Insect Antifeedants from Azadirachta indica. Part 4. Synthesis Towards the Limonoid Azadirachtin; Preparation of a Functionalized Decalin Fragment.
Authors: LEY S. V. , ABAD SOMOVILLA A. , BROUGHTON H. B. , CRAIG D. , SLAWIN A. M. Z. , TOOGOOD P. L. , WILLIAMS D. J. 
Published: May 2016

AbstractThe functionalized decalin fragment (VIII), a possible synthetic precursor of the naturally occurring insect antifeedant azadirachtin (IX), is prepared starting from (I) and (II).
ChemInform Abstract: Vanadium Oxides (V2Ox) Catalysts for Dry‐Type and Simultaneous Removal of Sulfur Oxides and Nitrogen Oxides with Ammonia at Low Temperature.
Authors: KASAOKA S. , SASAOKA E. , IWASAKI H. 
Published: May 2016

AbstractIt is found that V2Ox supported on TiO2 is a suitable catalyst for the simultaneous removal of SOx and NOx from waste gases.
ChemInform Abstract: Alkane Functionalization on a Preparative Scale by Mercury‐Photosensitized Cross‐Dehydrodimerization.
Authors: BROWN S. H. , CRABTREE R. H. 
Published: May 2016

AbstractAlkanes such as (I) can be functionalized in high chemical and quantum yields on a multigram scale by the mercury‐photosensitized reaction with alcohols, ethers or silanes such as (II) or (IV) to give the cross‐dimers (III) or (V).
ChemInform Abstract: Novel Trinuclear Mixed‐Metal Complexes Containing the Heteronuclear Ions (MII((OH)CrA4(OH))2(H2O)4)4+ and (MII((OH)CoA4(OH))2(H2O)4)4+ (A: Amine Ligand).
Authors: CORBIN K. M. , HODGSON D. J. , LYNN M. H. , MICHELSEN K. , NIELSEN K. M. , PEDERSEN E. 
Published: May 2016

AbstractThe title complexes (I) are obtained according to a literature method from the appropriate metal chlorides and cis‐dihydroxotetraminechromium(III) dithionate.
ChemInform Abstract: Syntheses of Bile Pigments. Part 16. Synthesis of a Vinyl‐Substituted 2,3‐Dihydrobilinedione: Possible Role of This New Class of Bile Pigments in Phycobilin Biosynthesis.
Authors: GOSSAUER A. , NYDEGGER F. , BENEDIKT E. , KOEST H.‐P. + 
Published: May 2016

AbstractStarting from the pyrrole precursors (I) and (II), the racemic bile pigment derivative (Va) is obtained.
ChemInform Abstract: Ozonolysis of Alkenes and a Study of the Reactions of Polyfunctional Compounds. Part 38. Synthesis of Isopropyl 3,7,11‐Trimethyl‐11‐methoxy‐2E,4E‐dodecadienoate.
Authors: ODINOKOV V. N. , KUKOVINETS O. S. , ZAINULLIN R. A. , TOLSTIKOV G. A. 
Published: May 2016

AbstractStarting from 1,5‐dimethylcyclooct‐1‐ene (I), which is submitted to ozonolysis, an 82:18 mixture of the isomeric 2E,4E‐ and 2Z,4E‐configurated isopropyl esters (VII) and (VIII) is prepared in 15% overall yield.
ChemInform Abstract: Photochemical Etching of n‐GaAs in Hydroxides.
Authors: SVORCIK V. , RYBKA V. , POKORNY J. , MYSLIK V. 
Published: May 2016

AbstractLaser‐stimulated etching of (100) oriented n‐GaAs is studied in 0.01, 0.1, and 1.0 M aqueous solutions of LiOH, NaOH, KOH, RbOH, and CsOH.
ChemInform Abstract: A Controlled Atmosphere in situ X‐Ray Diffraction Study of the Activation and Performance of Ammonia Synthesis Catalysts Derived from CeRu2, CeCo2, and CeFe2.
Authors: WALKER A. P. , RAYMENT T. , LAMBERT R. M. 
Published: May 2016

AbstractAmmonia synthesis catalysts are derived from the title precursors by decomposition of the intermetallic alloys in pure H2, N2/H2 and CO/H2 under various regimes of temp. and pressure and a comparison is made between hydride‐based catalysts and the corresponding oxide‐based materials.
ChemInform Abstract: Unexpected Course of Thiocyanation of 1,6‐Methano(10)annulene. Elimination of Thiocyanogen from a Diisothiocyanate.
Authors: NEIDLEIN R. , CONSTANTINESCU T. 
Published: May 2016

AbstractReaction of annulene (I) with thiocyanogen (II) (in situ from NH4SCN and Br2) leads to the expected thiocyanate (IV) but in addition the unusual products isothiocyanate (V) and diisothiocyanate (VI) are found as well.
ChemInform Abstract: Syntheses of Some Hexacarboxylic Acid Derivatives of Hexaazatriphenylene.
Authors: KANAKARAJAN K. , CZARNIK A. W. 
Published: May 2016

AbstractHexaazatriphenylenehexacarboxylic acid trianhydride (II) generated in situ reacts with the primary amines (III), dimethylamine (VIa), or methanol (VIb) to give the tricarboxylic acid derivatives (IV) or (VII).
ChemInform Abstract: Concave Reagents. Part 2. Macrobicyclic 1,10‐Phenanthrolines.
Authors: LUENING U. + , MUELLER M. + 
Published: May 2016

AbstractMetal ion template‐assisted bis‐condensation between the dialdehyde (I) and the diamines (II) affords the corresponding Schiff bases, i.e. macrocyclic 1,10‐phenanthrolinediimines which form isolable Pb2+ complexes.
ChemInform Abstract: Synthesis, Structure and Reactivity of a 1,3‐Diphospha‐2‐silaallyl Anion.
Authors: NIECKE E. , KLEIN E. , NIEGER M. 
Published: May 2016

AbstractThe title anion, the first example of a stable delocalized 3p(π) bonding system, is prepared as its Li salt (V) according to the scheme.
ChemInform Abstract: Stereospecific Iron Uptake Mediated by Phytosiderophore in Gramineous Plants.
Authors: OIDA F. , OTA N. , MINO Y. , NOMOTO K. , SUGIURA Y. 
Published: May 2016

AbstractNatural phytosiderophores are low‐molecular weight iron chelators, which regulate the iron uptake in gramineous plants.
ChemInform Abstract: Sensing Characteristics and Working Mechanism of Four‐Probe Type Solid‐State Hydrogen Sensor Using Proton Conductor.
Authors: MIURA N. , HARADA T. , YAMAZOE N. 
Published: May 2016

AbstractA four‐probe type electrochemical cell with a solid‐state proton conductor (Sb2O5·4 H2O) sensor capable of detecting dilute hydrogen in air at room temp. is described in detail.
Young adult female cancer survivors' unmet information needs and reproductive concerns contribute to decisional conflict regarding posttreatment fertility preservation
Authors: Benedict Catherine , Thom Bridgette , N. Friedman Danielle , Diotallevi Debbie , M. Pottenger Elaine , J. Raghunathan Nirupa , Kelvin Joanne F. 
Published: May 2016

BACKGROUNDMany young adult female cancer survivors (YAFCS) are at risk of experiencing premature menopause. The current study characterized the posttreatment fertility information needs, reproductive concerns, and decisional conflict regarding future options for posttreatment fertility preservation (FP) among YAFCS.METHODSParticipants completed a Web‐based, anonymous survey between February and March 2015. The survey included investigator‐designed questions of perceived information needs, the Reproductive Concerns After Cancer Scale, and the Decisional Conflict Scale. Analyses included Pearson correlation coefficients, independent‐sample Student t tests, and multiple regression.RESULTSThere was a total of 346 participants with an average age of 29.9 years (SD = 4.1 years) who were 4.9 years from treatment (SD = 5.4 years [range, 0‐27 years]). The main analyses focused on a subgroup of YAFCS with uncertain fertility status who had not previously undergone/attempted FP and either wanted future children or were unsure (179 women). Across fertility information topics, 43% to 62% of participants reported unmet information needs. The greatest reproductive concerns were related to fertility potential and the health of future offspring. The regression model controlled for a priori covariates including current age, age at treatment completion, income, relationship status, nulliparity, and prior fertility evaluation. Greater unmet information needs were found to be related to greater decisional conflict (β = .43; p<.001); greater reproductive concerns were associated at the trend level (β = .14, p = .08; F[8,118] = 6.42, p<.001).CONCLUSIONSYAFCS with limited awareness or knowledge of their risk of experiencing premature menopause and FP options reported higher levels of decisional conflict regarding future FP. Posttreatment survivorship care should include comprehensive reproductive health counseling, including posttreatment FP options and family‐building alternatives. Cancer 2016;122:2101–9. © 2016 American Cancer Society.
Chronic exposure to ivabradine reduces readmissions in the vulnerable phase after hospitalization for worsening systolic heart failure: a post‐hoc analysis of SHIFT
Authors: Komajda Michel , Tavazzi Luigi , Swedberg Karl , Böhm Michael , Borer Jeffrey S. , Moyne Aurélie , Ford Ian ,   on behalf of the SHIFT Investigators
Published: May 2016

AbstractAimsDuring the post‐discharge phase following a heart failure hospitalization (HFH), patients are at high risk of early readmission despite standard of care therapy. We examined the impact of chronic exposure to ivabradine on early readmissions in patients hospitalized for heart failure during the course of the SHIFT study (Systolic Heart Failure treatment with the If inhibitor ivabradine Trial).Methods and resultsA total of 1186 of the 6505 randomized patients experienced at least one HFH during the study, and had a more severe profile than those without HFH. Of these 1186 patients, 334 patients (28%) were rehospitalized within 3 months for any reason, mostly for cardiovascular causes (86%), including HFH (61%). Ivabradine was associated with fewer all‐cause hospitalizations at 1 month [incidence rate ratio (IRR) 0.70, 95% confidence interval (CI) 0.50–1.00, P < 0.05], 2 months (IRR 0.75, 95% CI 0.58–0.98, P = 0.03), and 3 months (IRR 0.79, 95% CI 0.63–0.99, P = 0.04). A trend for a reduction in cardiovascular and HF hospitalizations was also observed in ivabradine‐treated patients.ConclusionWe demonstrate in this post‐hoc analysis that chronic exposure to ivabradine reduces the incidence of all‐cause hospitalizations during the vulnerable phase after a HFH. Further studies are needed to investigate if in‐hospital or early post‐discharge initiation of ivabradine could be useful to improve early outcomes in patients hospitalized for HF.