bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of genomic rearrangements from targeted resequencing data in Parkinson's disease patients
Authors: Spataro Nino , Roca‐Umbert Ana , Cervera‐Carles Laura , Vallès Mònica , Anglada Roger , Pagonabarraga Javier , Pascual‐Sedano Berta , Campolongo Antònia , Kulisevsky Jaime , Casals Ferran , Clarimón Jordi , Bosch Elena 
Published: November 2016

ABSTRACTBackgroundThe analysis of coverage depth in next‐generation sequencing data allows the detection of gene dose alterations. We explore the frequency of such structural events in a Spanish cohort of sporadic PD cases.MethodsGene dose alterations were detected with the eXome‐Hidden Markov Model (XHMM) software from depth of coverage in resequencing data available for 38 Mendelian and other risk PD loci in 394 individuals (249 cases and 145 controls) and subsequently validated by quantitative PCR.ResultsWe identified 10 PD patients with exon dosage alterations in PARK2, GBA‐GBAP1, and DJ1. Additional functional variants, including 2 novel nonsense mutations (p.Arg1552Ter in LRRK2 and p.Trp90Ter in PINK1), were confirmed by Sanger sequencing. This combined approach disclosed the genetic cause of 12 PD cases.ConclusionsGene dose alterations related to PD can be correctly identified from targeting resequencing data. This approach substantially improves the detection rate of cases with causal genetic alterations. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Curcumin improves glucose tolerance via stimulation of glucagon‐like peptide‐1 secretion
Authors: Kato Masaki , Nishikawa Sho , Ikehata Akiho , Dochi Kojiro , Tani Tsubasa , Takahashi Tsukasa , Imaizumi Atsushi , Tsuda Takanori 
Published: November 2016

ScopeGlucagon‐like peptide‐1 (GLP‐1) is a type of incretin secreted from enteroendocrine L‐cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP‐1 in enteroendocrine L cell line (GLUTag cells). However, it is not clear whether its action in vivo directly enhances GLP‐1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin‐induced GLP‐1 secretion has not been clarified.Methods and resultsGlucose tolerance was significantly improved in rats after pre‐administered curcumin (1.5 mg/kg) followed by intraperitoneal glucose injections via the stimulation of GLP‐1 secretion and the induction of insulin secretion. In GLUTag cells, curcumin‐induced GLP‐1 secretion was associated with G protein‐coupled receptor (GPR) 40/120. Furthermore, the glucose‐lowering effect induced by curcumin was significantly reduced after the administration of a GPR40/120 antagonist in rats.ConclusionThese findings demonstrate the biological function of curcumin as a GLP‐1 secretagogue and the possible molecular target that mediates GLP‐1 secretion. Increases in the secretion of endogenous GLP‐1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes.
Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction
Authors: Hiniker Susan M. , Rangaswami Arun , Lungren Matthew P. , Thakor Avnesh S. , Concepcion Waldo , Balazy Kathleen E. , Kovalchuk Nataliya , Donaldson Sarah S. 
Published: November 2016

AbstractHere, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0–4.3 mg/dl despite placement of bilateral internal–external biliary drains. The tumor was not resectable, and the patient was not a candidate for liver transplant due to nodal disease, for chemotherapy due to hyperbilirubinemia, or for local therapies aside from stereotactic body radiotherapy (SBRT). In this report, we discuss the successful use of SBRT in the management of this patient, and its role in allowing the patient to become a candidate for additional therapies.
Remote control of North Atlantic Oscillation predictability via the stratosphere
Authors: Hansen F. , Greatbatch R. J. , Gollan G. , Jung T. , Weisheimer A. 
Published: November 2016

The phase and amplitude of the North Atlantic Oscillation (NAO) are influenced by numerous factors, including sea‐surface temperature (SST) anomalies in both the Tropics and extratropics and stratospheric extreme events like stratospheric sudden warmings (SSWs). Analyzing seasonal forecast experiments, which cover the winters from 1979/1980–2013/2014, with the European Centre for Medium‐Range Weather Forecast model, we investigate how these factors affect NAO variability and predictability. Building on the idea that tropical influence might happen via the stratosphere, special emphasis is placed on the role of major SSWs. Relaxation experiments are performed, where different regions of the atmosphere are relaxed towards ERA‐Interim to obtain perfect forecasts in those regions. By comparing experiments with relaxation in the tropical atmosphere, performed with an atmosphere‐only model on the one hand and a coupled atmosphere–ocean model version on the other, the importance of extratropical atmosphere–ocean interaction is addressed.Interannual variability of the NAO is best reproduced when perfect knowledge of the Northern Hemisphere (NH) stratosphere is available, together with perfect knowledge of SSTs and sea ice, in which case 64% of the variance of winter mean NAO is projected to be accounted for with a forecast ensemble of infinite size. The coupled experiment shows a strong bias in the stratospheric polar‐night jet (PNJ), which might be associated with a drift in the modelled SSTs resembling the North Atlantic cold bias and an underestimation of blockings in the North Atlantic/Europe sector. Consistent with the stronger PNJ, the lowest frequency of major SSWs is found in this experiment. However, after removing the bias statistically, a perfect forecast of the tropical atmosphere and allowing two‐way atmosphere–ocean coupling in the extratropics seem to be key ingredients for successful SSW predictions. In combination with SSW occurrence, a clear shift of the predicted NAO towards lower values occurs.
Neutral losses of sodium benzoate and benzoic acid in the fragmentation of the [M + Na]+ ions of methoxyfenozide and tebufenozide via intramolecular rearrangement in electrospray ionization tandem mass spectrometry
Authors: Chai Yunfeng , Gao Guanwei , Shen Shanshan , Liu Xin , Lu Chengyin 
Published: November 2016

RationaleElectrospray ionization (ESI) tandem mass spectrometry can be applied to determine structural information about organic compounds. The [M + Na]+ ion is one of the major precursor ions in ESI mass spectrometry, but its fragmentation mechanism study is still insufficient. This study reveals the interesting fragmentation reactions of the [M + Na]+ ions of methoxyfenozide and tebufenozide.MethodsThe fragmentations of the [M + Na]+, [M + Li]+, and [M + H]+ ions of methoxyfenozide and tebufenozide were studied using a hybrid quadrupole‐orbitrap mass spectrometer and an ion trap mass spectrometer. A hydrogen/deuterium (H/D)‐exchange experiment in the amide group of methoxyfenozide allowed for the confirmation of the fragmentation mechanism. Density functional theory (DFT) calculations were performed for a further understanding of the fragmentation mechanism of the [M + Na]+ ion of methoxyfenozide.ResultsNeutral losses of sodium benzoate and benzoic acid in the fragmentation of the [M + Na]+ ions of methoxyfenozide and tebufenozide were observed as the major fragmentation pathways. In contrast, similar fragmentations were not observed or minor pathways in the fragmentation of the [M + Li]+ and [M + H]+ ions of methoxyfenozide and tebufenozide. In addition, a minor product ion resulting from loss of NaOH was identified, which was the first reported example in the fragmentation of sodiated compounds in mass spectrometry.ConclusionsLosses of sodium benzoate and benzoic acid in the fragmentation of the [M + Na]+ ions of methoxyfenozide and tebufenozide are proposed to be formed through an intramolecular rearrangement reaction, which is supported by DFT calculations. An H/D‐exchange experiment confirms that the carboxyl hydrogen of benzoic acid and the hydrogen of NaOH exclusively derive from the amide hydrogen of the precursor ion. This study enriches our knowledge on the Na+‐induced fragmentation reactions. Copyright © 2016 John Wiley & Sons, Ltd.
Trauma-Informed Care Is the Best Clinical Practice in Rehabilitation Nursing
Authors: Freeman Williamson Laneita , Kautz Donald D. 
Published: November 2016

Abstract

Purpose:
This clinical article explores how trauma-informed care (TIC) can be used by rehabilitation nurses with patients who have experienced pervasive adverse childhood experiences (ACEs).

Method (Intervention Strategies):
This clinical article gives suggestions for using the five guiding principles of TIC: safety, trustworthiness, choice, collaboration, and empowerment, as the best clinical practice.

Conclusion:
Implementing TIC promotes successful rehabilitation, improves patient outcomes, and reduces costs. For every $1 spent on TIC, $5 is saved in lifetime costs.

Clinical Relevance:
ACEs cause physiological changes in the brain, leading to antisocial and risky behaviors, which may result in head injuries, spinal cord injuries, amputations, and multiple traumas with subsequent rehabilitation admissions, as well as obesity, and chronic illnesses. TIC is a cultural shift: We as providers must ask ourselves “What happened to this person?” instead of “What is wrong with this person?” Nurses are beginning to develop our literature and practice of TIC.
Evaluation of an Exercise Program for Older Adults in a Residential Environment
Authors: Shin Juh Hyun 
Published: November 2016

Abstract

Purpose:
The aim of this study was to examine the effectiveness of an older adult exercise program in a senior-living complex campus.

Design:
A longitudinal one-group design was used.

Methods:
To supply residents with tools to maintain or improve general quality of life, balance, endurance, depression, and functional mobility, the Wellness and Fitness Center at the research setting provided a wide assortment of user-friendly equipment with many options. One fitness director in the selected setting evaluated participants every 6 months with 33 participants using the Senior Fitness Test (SFT).

Findings:
Repeated ANOVAs identified factors impacting the effects of the exercise program using PROC MIXED SAS 9.0. The improvement or deterioration rate of SFT scores was tested as a time effect in balance, upper body strength, and lower body flexibility. A statistically significant gender effect emerged on the 6-minute walk, which measured aerobic endurance and the chair sit-and-reach test, which measured lower body flexibility.

Conclusions:
The 8-foot up-and-go, arm curl, chair stand, and chair sit-and-reach tests showed statistically significant improvement over time, which means balance, upper body strength, lower body strength, and lower body flexibility improved.

Clinical Relevance:
Developing customized exercise protocols and using standardized measurement tools should be encouraged to enhance effective research and consistent measurement of exercise programs.
A Performant Dry Reforming Catalytic System Elaborated from the Reductive Decomposition of BaNi2V2O8
Authors: Guerrero‐Caballero Jesus , Löfberg Axel , Mentré Olivier , Kane Tanushree , Pussacq Tanguy , Roussel Pascal , Huvé Marielle , Trentesaux Martine , Gardoll Olivier , Kabbour Houria 
Published: November 2016

AbstractThe reductive decomposition of BaNi2V2O8 leads to a Ni‐supported catalyst composed by an intimate blend of Ba3(VO4)2/Ni/BaV10O15. High activity for the Dry Reforming of Methane (DRM) is attained with 85 % conversion for CH4 and CO2, as well as a very good stability in time and a high selectivity with H2/CO=0.9 and negligible carbon deposition. A rich redox and optimal oxide‐metal interactions provide a unique and promising catalytic system.
Organocatalytic Enantioselective Friedel‐Crafts Reaction of Sesamol and Electron–rich Phenols with Alkylideneindolenine Intermediates Generated from Arylsulfonyl Indoles
Authors: Chang Chia‐Hao , Han Jeng‐Liang 
Published: November 2016

AbstractWe have developed the organocatalyzed asymmetric Friedel‐Crafts reaction of sesamol and electron‐rich phenols with various alkylideneindolenine intermediates generated from arylsulfonyl Indoles by using cinchona alkaloid‐urea bifunctional organocatalysts. A broad range of enantioenriched Friedel‐Crafts adducts with a tertiary stereocenter could be smoothly synthesized in good to excellent yields with moderate to good enantioselectivities.
Quinolyl‐Amidinates Chelating Bimetallic Magnesium and Mononuclear Aluminum Complexes for ϵ‐Caprolactone Polymerization
Authors: Xi Yanxia , Rajendran Natesan Mannangatti , Zhang Wenjuan , Sun Yang , Lei Ming , Sun Wen‐Hua 
Published: November 2016

AbstractA series of quinolyl‐amidinate compounds ((Ar–N=C(Ph)–N(H)–C9H5N–2–Me: Ar=2,6‐Me2C6H3 (L1), 2,6‐Et2C6H3 (L2), 2,6‐iPr2C6H3 (L3), 2,4,6‐Me3C6H2 (L4), 2,6‐Et2‐4‐MeC6H2 (L5)) was synthesized. These compounds in toluene reacted with C2H5MgBr forming the bimetallic bromomagnesium complexes (Mg1 ‐ Mg5) in high yields, and with AlMe3 producing dimethyl aluminum complexes (Al1 ‐ Al5) in high yields. All organic compounds and their corresponding magnesium and aluminum complexes were characterized by elemental and spectroscopic analyses. The ambiguous structures of complexes Mg2, Mg5 and Al1 were determined by the single crystal X‐ray diffraction analysis, reflecting bimetallic feature of complexes Mg2 and Mg5 with five‐coordination around magnesium atoms and mononuclear aluminum complex Al1 as a distorted trigonal‐bipyramidal geometry. All magnesium and aluminum complexes initiate the ring opening polymerization of ϵ‐caprolactone with good conversion yields. Aluminum complexes showed better activity with TOF up to 3678 h−1 at 80 °C in the presence of BnOH, while bromomagnesium complexes attained the good conversion of ϵ‐CL without of BnOH.
Handcrafted Vacuum‐Assisted Device for Skin Ulcers Treatment Versus Traditional Therapy, Randomized Controlled Trial
Authors: Gonzalez Israel Gonzalez , Angel Medina Andrade Luis , Baez Maria Valeria Jimenez , Ruiz Flores Brenda , de los Angeles Martinez Ferretiz Maria , Woolf Stephanny Vanestty , López Israel , Sandoval‐Jurado Luis , Pat‐Espadas Fany Guadalupe , Cruz Alan Alejandro Reyes , Delgado Arsenio Torres 
Published: November 2016

AbstractBackgroundChronic lower limb ulcers constitute a public health problem, with important socioeconomic implications and high attention cost. This trial evaluates handcrafted vacuum‐assisted therapy versus traditional treatment effectiveness for lower limbs ulcers.Materials and methodsIt was a prospective randomized clinical trial conducted over 144 patients with lower limbs ulcers. Patients were randomized into two groups of 72 patients: Experimental group were treated with debridement, cure and a handcrafted vacuum‐assisted device that was changed every 72 h. Control group was treated with debridement and cure with soap every 24 h. Ulcers were evaluated every 72 h and on 10th day. The presence of systemic inflammatory response, pain, granulation tissue and viability for discharge was registered and analyzed.ResultsAfter exclusion of 18 patients, 126 were included, 65.1% were men with an average of 58 years. Sole region ulcer by diabetic foot was the more frequent in both groups (73%). Leukocytes count, systemic inflammatory response and pain were significantly lower in experimental group (p < 0.05). Discharge criteria and granulation tissue were present earlier in experimental group (p < 0.05).ConclusionHandcrafted vacuum‐assisted system is a feasible and safe method to treat chronic ulcers. This system would benefit patients favoring earlier infection control, faster granulation tissue appearance and earlier discharge.Clinical trials registered in https://www.clinicaltrials.gov/ Number NCT02512159.
Portal Supply and Venous Drainage of the Caudate Lobe in the Healthy Human Liver: Virtual Three‐Dimensional Computed Tomography Volume Study
Authors: Benkö T. , Sgourakis G. , Molmenti E. P. , Peitgen H. O. , Paul A. , Nadalin S. , Schroeder T. , Radtke A. 
Published: November 2016

AbstractObjectiveThe venous vascular anatomy of the caudate lobe is exceptional. The purpose of this study was to assess portal inflow and venous outflow volumes of the caudate lobe.MethodsExtrahepatic (provided by the first‐order branches) versus intrahepatic (provided by the second‐ to third‐order branches) portal inflow, as well as direct (via Spieghel veins) versus indirect (via hepatic veins) venous drainage patterns were analyzed in virtual 3‐D liver maps in 140 potential live liver donors.ResultsThe caudate lobe has a greater intrahepatic than extrahepatic portal inflow volume (mean 55 ± 26 vs. 45 ± 26%: p = 0.0763), and a greater extrahepatic than intrahepatic venous drainage (mean 54–61 vs. 39–46%). Intrahepatic drainage based on mean estimated values showed the following distribution: middle > inferior (accessory) > right > left hepatic vein.ConclusionsSacrifice of extrahepatic caudate portal branches can be compensated by the intrahepatic portal supply. The dominant outflow via Spieghel veins and the negligible role of left hepatic vein in caudate venous drainage may suggest reconstruction of caudate outflow via Spieghel veins in instances of extended left hemiliver live donation not inclusive of the middle hepatic vein. The anatomical data and the real implication for living donors must be further verified by clinical studies.
Comparative Validation of Abdominal CT Models that Predict Need for Surgery in Adhesion‐Related Small‐Bowel Obstruction
Authors: Yang Phillip F. , Rabinowitz Dean P. , Wong Shing W. , Khan Maroof A. , Gandy Robert C. 
Published: November 2016

AbstractIntroductionAdhesion‐related small‐bowel obstruction (ASBO) can be managed without surgery in selected patients. The aim of this study was to validate three previously published computed tomography (CT) models that predict need for surgery.MethodsA retrospective study of patients with ASBO admitted to a tertiary referral hospital between November 2009 and April 2015 was conducted. Data on clinical variables were extracted from medical records. CT signs were assessed by a radiologist who was blinded to whether or not the patients required surgery. Three previously published models were validated by testing their ability to predict need for surgery.ResultsThe cohort comprised 233 patients with ASBO (mean age 69.7 years, 47.6% male), of whom 73 (31.3%) required surgery. A predictive model using a combination of mesenteric oedema, free intraperitoneal fluid and absence of small‐bowel faecalisation had a sensitivity of 38% [95% CI 27–50%], specificity of 88% [81–92%], positive likelihood ratio (LR+) of 3.1 [1.6–5.1] and negative likelihood ratio (LR−) of 0.7 [0.6–0.8]. Only the results of one previously published model (which used a combination of obstipation, free intraperitoneal fluid and high‐grade or complete obstruction) could be reproduced. This model had a potentially clinically useful LR+ of 2.9 [1.1–7.4] and LR− of 0.9 [0.8–1.0]. The poor performances of the other two models may be partially explained by measurement bias.ConclusionThe performances of the previously published predictive models in this validation study were varied. Future attempts to develop models should use clearly defined, standardised and reproducible predictors wherever possible.
3D Printed Surgical Instruments: The Design and Fabrication Process
Authors: George Mitchell , Aroom Kevin R. , Hawes Harvey G. , Gill Brijesh S. , Love Joseph 
Published: November 2016

AbstractBackground3D printing is an additive manufacturing process allowing the creation of solid objects directly from a digital file. We believe recent advances in additive manufacturing may be applicable to surgical instrument design. This study investigates the feasibility, design and fabrication process of usable 3D printed surgical instruments.MethodsThe computer‐aided design package SolidWorks (Dassault Systemes SolidWorks Corp., Waltham MA) was used to design a surgical set including hemostats, needle driver, scalpel handle, retractors and forceps. These designs were then printed on a selective laser sintering (SLS) Sinterstation HiQ (3D Systems, Rock Hill SC) using DuraForm EX plastic. The final printed products were evaluated by practicing general surgeons for ergonomic functionality and performance, this included simulated surgery and inguinal hernia repairs on human cadavers. Improvements were identified and addressed by adjusting design and build metrics.ResultsRepeated manufacturing processes and redesigns led to the creation of multiple functional and fully reproducible surgical sets utilizing the user feedback of surgeons. Iterative cycles including design, production and testing took an average of 3 days. Each surgical set was built using the SLS Sinterstation HiQ with an average build time of 6 h per set.ConclusionsFunctional 3D printed surgical instruments are feasible. Advantages compared to traditional manufacturing methods include no increase in cost for increased complexity, accelerated design to production times and surgeon specific modifications.
Continued growth after fixation of slipped capital femoral epiphysis
Authors: Holmdahl Per , Backteman Torsten , Danielsson Aina , Kärrholm Johan , Riad Jacques 
Published: November 2016

Purpose When treating slipped capital femoral epiphysis (SCFE), a smooth pin with a hook or a short threaded screw can be used to allow further growth, which could be important to prevent the development of impingement and early arthritis. The purpose of this investigation was to measure growth in three dimensions after fixation of SCFE. Methods Sixteen participants with unilateral SCFE, nine girls and seven boys with a median age of 12.0 years (range 8.4–15.7 years), were included. The slipped hip was fixed with a smooth pin with a hook, and the non-slipped hip was prophylactically pinned. At the time of surgery, tantalum markers were installed bilaterally on each side of the growth plate through the drilled hole for the pin. Examination with radiostereometric analysis (RSA) was performed postoperatively and at 3, 6 and 12 months. The position of the epiphysis in relation to the metaphysis was calculated. Results At 12 months, the epiphysis moved caudally, median 0.16 mm and posteriorly 2.28 mm on the slipped side, in comparison to 2.28 cranially and 0.91 mm posteriorly on the non-slipped side, p = 0.003 and p = 0.030, respectively. Both slipped and non-slipped epiphysis moved medially, 1.52 and 1.74 mm, respectively. A marked variation in the movement was noted, especially on the slipped side. Conclusions The epiphysis moved in relation to the metaphysis after smooth pin fixation, both on the slipped side and on the prophylactically fixed non-slipped side, implying further growth. The RSA method can be used to understand remodelling after ‘growth-sparing’ fixation of SCFE.