bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiemployer plans: evaluating a proposal to spread the pain
Authors: MUNNELL ALICIA , AUBRY JEAN-PIERRE , HOU WENLIANG , WEBB ANTHONY 
Published: January 2018

AbstractThe Multiemployer Pension Reform Act (MPRA) allows multiemployer plans facing insolvency to apply for approval from the Treasury to cut accrued benefits of plan members to prolong plan solvency—a departure from the benefit protections of Employee Retirement Income Security Act. To assess the law's impact, this paper models Central States Teamsters – by far the largest – plan to have applied under the new law to reduce benefits. Using a stochastic model of future investment returns, the probability of insolvency within 10 years drops from 50% (without cuts) to 6% (with cuts). While benefit cuts increase the overall welfare of participants by extending the plan's life, the welfare of younger retirees (under age 75) worsens and welfare of workers improves.
Beyond fresh and direct: exploring the specialty food industry as a market outlet for small- and medium-sized farms
Authors: Feenstra Gail , Hardesty Shermain , Lev Larry , Houston Laurie , King Robert , Joannides Jan 
Published: January 2018

AbstractAs small- and medium-sized farms struggle to remain viable in a competitive global economy, the expanding specialty food industry provides a potential marketing opportunity. These farms raise many of the farm products that can become the key ingredients in value-added foods. Little research exists about processed specialty foods made from locally/regionally sourced ingredients produced by small- and medium-sized farms. This study investigates the benefits, barriers and challenges for small- and medium-sized farmers who want to sell products to specialty food manufacturers (SFMs). This paper analyzes 240 survey responses from dairy, meat, fruit/vegetable/nuts and grain specialty manufacturers and 60 in-depth interviews of these manufacturers and farmers in California, Minnesota, Wisconsin, Washington and Oregon. We found that almost half of the manufacturers surveyed source primary ingredients directly from farms or from their own farm. More than half of the farms that supply these key ingredients are small or medium-sized, indicating that many farms in this category are already successfully supplying SFMs with key ingredients. The key benefits manufacturers receive from working with these farms included quality assurance, trust, and traceability. Key obstacles to such farmer/manufacturer transactions are: cost, inability to meet volume requirements, unreliable supply and lack of year-round supply. The nature of relationships between manufacturers and farmers emerged as a theme that influences the success of small- and medium-sized farms as ingredient suppliers. Whether they were large or small, most manufacturers purchased their key ingredients from multiple suppliers in order to reduce their risk. Overall, we find evidence that the specialty food industry is an emerging market channel for small- and medium-sized farms. We also find that to be successful suppliers of SFMs, farmers need to have processes in place to ensure the quality of their products; provide the specific attributes the manufacturer requires for its ingredients and be willing to communicate frequently with the manufacturer.
Energy limitation of cyanophage development: implications for marine carbon cycling
Authors: Puxty Richard J , Evans David J , Millard Andrew D , Scanlan David J 
Published: January 2018

Abstract
Marine cyanobacteria are responsible for ~25% of the fixed carbon that enters the ocean biosphere. It is thought that abundant co-occurring viruses play an important role in regulating population dynamics of cyanobacteria and thus the cycling of carbon in the oceans. Despite this, little is known about how viral infections ‘play-out’ in the environment, particularly whether infections are resource or energy limited. Photoautotrophic organisms represent an ideal model to test this since available energy is modulated by the incoming light intensity through photophosphorylation. Therefore, we exploited phototrophy of the environmentally relevant marine cyanobacterium Synechococcus and monitored growth of a cyanobacterial virus (cyanophage). We found that light intensity has a marked effect on cyanophage infection dynamics, but that this is not manifest by a change in DNA synthesis. Instead, cyanophage development appears energy limited for the synthesis of proteins required during late infection. We posit that acquisition of auxiliary metabolic genes (AMGs) involved in light-dependent photosynthetic reactions acts to overcome this limitation. We show that cyanophages actively modulate expression of these AMGs in response to light intensity and provide evidence that such regulation may be facilitated by a novel mechanism involving light-dependent splicing of a group I intron in a photosynthetic AMG. Altogether, our data offers a mechanistic link between diurnal changes in irradiance and observed community level responses in metabolism, i.e., through an irradiance-dependent, viral-induced release of dissolved organic matter (DOM).
Climate change promotes parasitism in a coral symbiosis
Authors: Baker David M , Freeman Christopher J , Wong Jane C Y , Fogel Marilyn L , Knowlton Nancy 
Published: January 2018

Abstract
Coastal oceans are increasingly eutrophic, warm and acidic through the addition of anthropogenic nitrogen and carbon, respectively. Among the most sensitive taxa to these changes are scleractinian corals, which engineer the most biodiverse ecosystems on Earth. Corals’ sensitivity is a consequence of their evolutionary investment in symbiosis with the dinoflagellate alga, Symbiodinium. Together, the coral holobiont has dominated oligotrophic tropical marine habitats. However, warming destabilizes this association and reduces coral fitness. It has been theorized that, when reefs become warm and eutrophic, mutualistic Symbiodinium sequester more resources for their own growth, thus parasitizing their hosts of nutrition. Here, we tested the hypothesis that sub-bleaching temperature and excess nitrogen promotes symbiont parasitism by measuring respiration (costs) and the assimilation and translocation of both carbon (energy) and nitrogen (growth; both benefits) within Orbicella faveolata hosting one of two Symbiodinium phylotypes using a dual stable isotope tracer incubation at ambient (26 °C) and sub-bleaching (31 °C) temperatures under elevated nitrate. Warming to 31 °C reduced holobiont net primary productivity (NPP) by 60% due to increased respiration which decreased host %carbon by 15% with no apparent cost to the symbiont. Concurrently, Symbiodinium carbon and nitrogen assimilation increased by 14 and 32%, respectively while increasing their mitotic index by 15%, whereas hosts did not gain a proportional increase in translocated photosynthates. We conclude that the disparity in benefits and costs to both partners is evidence of symbiont parasitism in the coral symbiosis and has major implications for the resilience of coral reefs under threat of global change.
The real-life costs of emotion regulation in anorexia nervosa: a combined ecological momentary assessment and fMRI study
Authors: Seidel Maria , King Joseph A. , Ritschel Franziska , Boehm Ilka , Geisler Daniel , Bernardoni Fabio , Holzapfel Larissa , Diestel Stefan , Diers Kersten , Strobel Alexander , Goschke Thomas , Walter Henrik , Roessner Veit , Ehrlich Stefan 
Published: January 2018

AbstractRegulation of emotions is necessary for successful attainment of short-term and long-term goals. However, over-regulation may also have its costs. In anorexia nervosa (AN), forgoing food intake despite emaciation and endocrine signals that promote eating is an example of “too much” self-control. Here we investigated whether voluntary emotion regulation in AN patients comes with associated disorder-relevant costs. Thirty-five patients with acute AN and thirty-five age-matched healthy controls (HCs) performed an established emotion regulation paradigm during functional magnetic resonance imaging after an overnight fast. The task required reducing emotions induced by positively valenced pictures via distancing. We calculated a neural regulation score from responses recorded in a reward-related brain region of interest (ventral striatum; VS) by subtracting activation measured on “positive distance” trials from that elicited under the “positive watch” (baseline) condition. Complementing the imaging data, we used ecological momentary assessment (EMA) to probe disorder-related rumination and affect six times/day for 2 weeks following the scanning session. The neural regulation score indicating reduced VS activation during emotion regulation was used as a predictor in hierarchical linear models with EMA measures as outcomes. No group differences in neural activity were found for the main contrasts of the task. However, regulation of VS activity was associated with increased body-related rumination and increased negative affect in AN, but not in HC. In line with this finding, correlational analysis with longitudinal BMI measurements revealed a link between greater VS regulation and poorer treatment outcome after 60 and 90 days. Together, these results identify a neural correlate of altered emotion regulation in AN, which seems to be detrimental to psychological well-being and may interfere with recovery.
Experimental quantum verification in the presence of temporally correlated noise
Authors: Mavadia S. , Edmunds C. L. , Hempel C. , Ball H. , Roy F. , Stace T. M. , Biercuk M. J. 
Published: January 2018

AbstractGrowth in the capabilities of quantum information hardware mandates access to techniques for performance verification that function under realistic laboratory conditions. Here we experimentally characterise the impact of common temporally correlated noise processes on both randomised benchmarking (RB) and gate-set tomography (GST). Our analysis highlights the role of sequence structure in enhancing or suppressing the sensitivity of quantum verification protocols to either slowly or rapidly varying noise, which we treat in the limiting cases of quasi-DC miscalibration and white noise power spectra. We perform experiments with a single trapped 171Yb+ ion-qubit and inject engineered noise $$\left( { \propto \hat \sigma _z} \right)$$

∝

σ

^

z

to probe protocol performance. Experiments on RB validate predictions that measured fidelities over sequences are described by a gamma distribution varying between approximately Gaussian, and a broad, highly skewed distribution for rapidly and slowly varying noise, respectively. Similarly we find a strong gate set dependence of default experimental GST procedures in the presence of correlated errors, leading to significant deviations between estimated and calculated diamond distances in the presence of correlated $$\hat \sigma _z$$

σ

^

z

errors. Numerical simulations demonstrate that expansion of the gate set to include negative rotations can suppress these discrepancies and increase reported diamond distances by orders of magnitude for the same error processes. Similar effects do not occur for correlated $$\hat \sigma _x$$

σ

^

x

or $$\hat \sigma _y$$

σ

^

y

errors or depolarising noise processes, highlighting the impact of the critical interplay of selected gate set and the gauge optimisation process on the meaning of the reported diamond norm in correlated noise environments.
Optical breakdown of solids by few-cycle laser pulses
Authors: Zhokhov P. A. , Zheltikov A. M. 
Published: January 2018

AbstractWe show that a broadly accepted criterion of laser-induced breakdown in solids, defining the laser-breakdown threshold in terms of the laser fluence or laser intensity needed to generate a certain fraction of the critical electron density rc within the laser pulse, fails in the case of high-intensity few-cycle laser pulses. Such laser pulses can give rise to subcycle oscillations of electron density ρ with peak ρ values well above ρc even when the total energy of the laser pulse is too low to induce a laser damage of material. The central idea of our approach is that, instead of the ρ = ρ
c
ratio, the laser-breakdown threshold connects to the total laser energy coupled to the electron subsystem and subsequently transferred to the crystal lattice. With this approach, as we show in this work, predictions of the physical model start to converge to the available experimental data.
Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase
Authors: Tyukhtenko Sergiy , Rajarshi Girija , Karageorgos Ioannis , Zvonok Nikolai , Gallagher Elyssia S. , Huang Hongwei , Vemuri Kiran , Hudgens Jeffrey W. , Ma Xiaoyu , Nasr Mahmoud L. , Pavlopoulos Spiro , Makriyannis Alexandros 
Published: January 2018

AbstractAn understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands with potential therapeutic value. Here, we report the discovery and characterization of an allosteric, regulatory hMGL site comprised of residues Trp-289 and Leu-232 that reside over 18 Å away from the catalytic triad. These residues were identified as critical mediators of long-range communication and as important contributors to the integrity of the hMGL structure. Nonconservative replacements of Trp-289 or Leu-232 triggered concerted motions of structurally distinct regions with a significant conformational shift toward inactive states and dramatic loss in catalytic efficiency of the enzyme. Using a multimethod approach, we show that the dynamically relevant Trp-289 and Leu-232 residues serve as communication hubs within an allosteric protein network that controls signal propagation to the active site, and thus, regulates active-inactive interconversion of hMGL. Our findings provide new insights into the mechanism of allosteric regulation of lipase activity, in general, and may provide alternative drug design possibilities.
One-stage technique for sagittal split ramus osteotomy combined with mandibular angle ostectomy
Authors: Chen Shuo , Zhang Yi , An Jin-gang , He Yang 
Published: January 2018

AbstractBilateral sagittal split ramus osteotomy (BSSRO) is commonly used to correct mandibular prognathism or retrognathism. Patients with mandibular prognathism or retrognathism may also present with a prominent mandibular angle. In this paper, we share our experience on BSSRO with mandibular angle resection. Eleven patients who were treated from July 2014 to December 2016 were included in this study. The mandibular angle was resected through the medial side of the mandible after BSSRO. The mandibular angle measurements of the patients changed significantly after surgery (p < 0.05). Unanticipated fractures and mandibular hematoma did not occur. Therefore, BSSRO combined with mandibular angle ostectomy through the medial side of the mandible can be used to safely and effectively correct facial deformity.
Shape evolution of ooids: a geometric model
Authors: Sipos András A. , Domokos Gábor , Jerolmack Douglas J. 
Published: January 2018

AbstractStriking shapes in nature have been documented to result from chemical precipitation — such as terraced hot springs and stromatolites — which often proceeds via surface-normal growth. Another studied class of objects is those whose shape evolves by physical abrasion — the primary example being river and beach pebbles — which results in shape-dependent surface erosion. While shapes may evolve in a self-similar manner, in neither growth nor erosion can a surface remain invariant. Here we investigate a rare and beautiful geophysical problem that combines both of these processes; the shape evolution of carbonate particles known as ooids. We hypothesize that mineral precipitation, and erosion due to wave-current transport, compete to give rise to novel and invariant geometric forms. We show that a planar (2D) mathematical model built on this premise predicts time-invariant (equilibrium) shapes that result from a balance between precipitation and abrasion. These model results produce nontrivial shapes that are consistent with mature ooids found in nature.
Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa
Authors: Kim Min Kyung , Kang Hee Kyoung , Ko Su Jin , Hong Min Ji , Bang Jeong Kyu , Seo Chang Ho , Park Yoonkyung 
Published: January 2018

AbstractHp1404, identified from the venom of the scorpion Heterometrus petersii, displays antimicrobial activity with cytotoxicity. Several synthetic peptides were designed based on the parent peptide Hp1404 to reduce cytotoxicity and improve activity (deletion of glycine and phenylalanine, substitution with leucine and lysine). The analogue peptides generated comprised 12 amino acids and displayed amphipathic α-helical structures, with higher hydrophobic moments and net positive charge than those of the Hp1404. The analogues showed less hemolytic and toxic effects toward mammalian cells than the Hp1404, especially Hp1404-T1e, which exhibited particularly potent antibacterial and antibiofilm activities against multidrug-resistant Pseudomonas aeruginosa (MRPA) strains. The analogue peptide Hp1404-T1e was more stable against salt and trypsin than the Hp1404. Hp1404’s mechanism of action involves binding to lipopolysaccharide (LPS), thereby killing bacteria through membrane disruption. Hp1404-T1e kills bacteria more rapidly than Hp1404 and not only seems to bind more strongly to LPS but may also be able to enter bacterial cells and interact with their DNA. Additionally, Hp1404-T1e can effectively kill bacteria in vivo. The results of this study indicate that Hp1404-T1e not only displays antimicrobial activity, but is also functional in physiological conditions, confirming its potential use as an effective therapeutic agent against MRPA.
3′,4′-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice
Authors: Lau Yeh Siang , Mustafa Mohd Rais , Choy Ker Woon , Chan Stanley M. H. , Potocnik Simon , Herbert Terence P. , Woodman Owen L. 
Published: January 2018

AbstractEndoplasmic reticulum (ER) stress has been implicated in the development of hypertension 3 through the induction of endothelial impairment. As 3′,4′-dihydroxyflavonol (DiOHF) 4 reduces vascular injury caused by ischaemia/reperfusion or diabetes, and flavonols have been demonstrated to attenuate ER stress, we investigated whether DiOHF can protect mice from ER stress-induced endothelial dysfunction. Male C57BLK/6 J mice were injected with tunicamycin to induce ER stress in the presence or absence of either DiOHF or tauroursodeoxycholic acid (TUDCA), an inhibitor of ER stress. Tunicamycin elevated blood pressure and impaired endothelium-dependent relaxation. Moreover, in aortae there was evidence of ER stress, oxidative stress and reduced NO production. This was coincident with increased NOX2 expression and reduced phosphorylation of endothelial nitric oxide synthase (eNOS) on Ser1176. Importantly, the effects of tunicamycin were significantly ameliorated by DiOHF or TUDCA. DiOHF also inhibited tunicamycin-induced ER stress and apoptosis in cultured human endothelial cells (HUVEC). These results provide evidence that ER stress is likely an important initiator of endothelial dysfunction through the induction of oxidative stress and a reduction in NO synthesis and that DiOHF directly protects against ER stress- induced injury. DiOHF may be useful to prevent ER and oxidative stress to preserve endothelial function, for example in hypertension.
SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis
Authors: Wang Yun-Liang , Xue Peng , Xu Chun-Yang , Wang Zhen , Liu Xin-Shan , Hua Lin-Lin , Bai Hong-Ying , Zeng Zhi-Lei , Duan Hai-Feng , Li Jin-Feng 
Published: January 2018

AbstractMultiple Sclerosis (MS), is a chronic inflammatory autoimmune disorder of the central nervous system that leads to chronic demyelination with axonal damage and neuronal loss. Mesenchymal stem cells (MSCs) represent a promising therapeutic approach for MS. In the current study, we investigated the effects of MSCs derived from the human umbilical cord (UCMSC) transfected by sphingosine kinase 1 (SPK1) gene. All the results showed that transplantation of UCMSCs gene modified by SPK1 (UCMSC-SPK1) dramatically reduce the severity of neurological deficits of the experimental autoimmune encephalomyelitis (EAE) mice, paralleling by reductions in demyelination, axonal loss, and astrogliosis. UCMSC-SPK1 transplantation also could inhibit the development of natural killer (NK) responses in the spleen of EAE mice, and increase the ratio of CD4+ CD25+ FoxP3+ (Treg) T cells. Furthermore, we described that a shift in the cytokine response from Th1/Th17 to Th2 was an underlying mechanism that suppressed CNS autoimmunity. UCMSCs transfected by SPK1 gene potentially offer a novel mode for the treatment of MS, and the specific mechanism of SPK1 in treating MS/EAE.
Maturation of Pain Empathy from Child to Adult Shifts from Single to Multiple Neural Rhythms to Support Interoceptive Representations
Authors: Levy Jonathan , Goldstein Abraham , Pratt Maayan , Feldman Ruth 
Published: January 2018

AbstractWhile empathy to the pain of conspecific is evolutionary-ancient and is observed in rodents and in primates, it also integrates higher-order affective representations. Yet, it is unclear whether human empathy for pain is inborn or matures during development and what neural processes underpin its maturation. Using magnetoencephalography, we monitored the brain response of children, adolescents, and adults (n = 209) to others’ pain, testing the shift from childhood to adult functioning. Results indicate that children’s vicarious empathy for pain operates via rudimentary sensory predictions involving alpha oscillations in somatosensory cortex, while adults’ response recruits advanced mechanisms of updating sensory predictions and activating affective empathy in viceromotor cortex via higher-level representations involving beta- and gamma-band activity. Our findings suggest that full-blown empathy to others’ pain emerges only in adulthood and involves a shift from sensory self-based to interoceptive other-focused mechanisms that support human altruism, maintain self-other differentiation, modulate feedback to monitor other’s state, and activate a plan of action to alleviate other’s suffering.