bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
Authors: Zhang Hongwei , Xu Qixia , Jiang Zhirui , Sun Rong , Liu Sanhong , kirkland James L. , Zhang Weidong , Sun Yu 
Published: September 2024

AbstractCellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with natural aging, functionally contributing to age-related organ dysfunction and multiple disorders. In this study, we performed a large scale screening of a natural product library for senotherapeutic candidates by assessing their effects on human senescent cells. Apigenin, a dietary flavonoid previously reported with antioxidant and anti-inflammatory activities, exhibited a prominent capacity in targeting senescent cells as a senomorphic agent. In senescent cells, apigenin blocks the interactions between ATM/p38 and HSPA8, thus preventing transition of the acute stress-associated phenotype (ASAP) towards the SASP. Mechanistically, apigenin targets peroxiredoxin 6 (PRDX6), an intracellular redox-active molecule, suppressing the iPLA2 activity of PRDX6 and disrupting downstream reactions underlying the SASP development. Without reversing cellular senescence, apigenin deprives cancer cells of malignancy acquired from senescent stromal cells in culture, while reducing chemoresistance upon combination with chemotherapy in anticancer regimens. In preclinical trials, apigenin administration improves physical function of animals prematurely aged after whole body irradiation, alleviating physical frailty and cognitive impairment. Overall, our study demonstrates the potential of exploiting a naturally derived compound with senomorphic capacity to achieve geroprotective effects by modulating the SASP, thus providing a research platform for future exploration of novel natural agents against age-related conditions.
Combination ofBRCAdeep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer
Authors: Nguyen Thien-Phuc Hoang , Tran Nam HB , Nguyen Tien Anh , Ngo My TT , Doan Anh Duong , Nguyen Du Quyen , Tang Hung Sang , Nguyen Duy Sinh , Nguyen Thi Cam Tu , Do Thi Thanh Thuy , Nguyen Hoai-Nghia , Giang Hoa , Tu Lan N 
Published: September 2024

AbstractBackgroundsAssessing homologous recombination deficiency (HRD) has been recommended by clinical guidelines for patients with ovarian cancer (OC) as it predicts sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi). However, HRD testing is complex and either inaccessible or unaffordable for majority of OC patients in developing countries. Consequently, the prevalence of HRD in OC remains unknown.MethodsWe examined HRD status of 77 Vietnamese patients with OC using a new laboratory-developed test (HRD Insight, Gene Solutions). Tumor DNA was extracted from FFPE samples, followed by next-generation sequencing to detect deleterious or suspected deleterious variants inBRCA1/2genes. Shallow whole genome sequencing was performed to determine the whole Genomic Instability (wGI) score by assessing the presence of large-scale intra-chromosomal copy number alterations.ResultsThe assay was first benchmarked against commercial HRD kits including TruSight Oncology 500 HRD (Illumina), SOPHiA DDM HRD Solutions (Sophia Genetics) and HRD Focus Panel (AmoyDx), and showed an overall percent agreement of 90.0%, 96.3%, and 96.4% respectively. The successful rate of sequencing was 94.8% (73/77) and the prevalence of HRD in OC patients was 54.8% (40/73).BRCAmutations and positive wGI scores were found in 16.4% (12/73) and 47.9% (35/73) of the patients respectively. Among those with wild-typeBRCA1/2, 40.5% of them had positive wGI scores and hence positive HRD. Age at diagnosis was not affected by bothBRCAand wGI status.ConclusionsHRD Insight assay could accurately and robustly determine the HRD status of ovarian tissue samples, including those with low quality.
Driving engagement in metaverse-mediated tourism environments: exploring the role of perceived realism
Authors: Cheung Man Lai , Leung Wilson K.S. , Chang Man Kit , Wong Randy Y.M. , Tse Sin Yan 
Published: September 2024

PurposeDespite the promising development and marketing potential of the metaverse, our understanding of how realistic metaverse environments impact user engagement and behaviours remains limited. This study investigates the role of perceived realism in influencing user engagement, thereby affecting external search behaviour and visit intentions.Design/methodology/approachWe surveyed 270 active metaverse users to test the research model. The data were analysed using partial least squares structural equation modelling (PLS-SEM).FindingsThe results of our study show that three dimensions of realism – avatar involvement, perceptual pervasiveness and social realism – significantly enhance user engagement, which in turn influences external search behaviour and visit intention. In contrast, simulation realism and freedom of choice have minimal effects on absorption and dedication.Research limitations/implicationsThis study highlights the role of perceived realism in enhancing user engagement with the metaverse and its impact on physical world behaviours. It contributes to metaverse literature by demonstrating that engagement within the metaverse significantly influences physical world behaviours, including visit intentions and external search behaviours.Practical implicationsThis study offers practical guidance for developers to enhance user engagement in metaverse environments. Specifically, our findings advocate for visual and audio quality enhancements, greater persuasiveness of virtual spaces, improved avatar representativeness and a closer alignment of metaverse activities with real-life events.Originality/valueThis study advances the theoretical understanding of perceived realism by examining how its dimensions – such as visual and audio quality, avatar representativeness and alignment with real-life events – impact user engagement in the metaverse. It also explores how this engagement influences offline behaviours, thus bridging the gap between virtual and real-world interactions.
Adapting accounting education to evolving business paradigm-an Indian perspective
Authors: Nanjundaswamy Abhishek , Divyashree M.S. , Suraj Neethu , Kulal Abhinandan , Rahiman Habeeb Ur , Kodikal Rashmi 
Published: September 2024

PurposeThis study examines the need for an accounting curriculum to evolve in response to the changing business landscape. Specifically, this study aims to explore the relationship between various market forces, the shifting dynamics of business, and the importance of adapting accounting education to these changes.Design/methodology/approachThis study is a combination of both quantitative and qualitative research. A structured questionnaire was administered to 320 professionals to gather data, and the study employed descriptive analysis, one-sample t-tests, and structured equation modeling to analyze the relationship between the variables.FindingsThe findings reveal a strong correlation between business transformation and the imperative to adapt accounting education. This study emphasizes the significance of modifying accounting curricula to align with the current market trends. Furthermore, this study addresses the pressing concern of sustainability and the triple bottom line (TBL), advocating specialized education in sustainability accounting programs.Research limitations/implicationsDespite its contributions, this study acknowledges a limitation in its focus solely on the perceptions of professionals and academicians regarding the impact of business transformation on accounting education, without directly examining the prevailing accounting education system. Future research should address this limitation by undertaking a qualitative exploration of the actual accounting education landscape and market requirements.Practical implicationsThe implications of the study span the theoretical, regulatory, environmental, and social domains, stressing the need for educational institutions, regulatory bodies, and industry to collaborate in shaping competent and future-ready accounting professionals. A systematic approach would validate and extend the findings of this study, providing deeper insights into the transformative processes necessary to enhance accounting education in response to evolving business landscapes and environmental dynamics.Originality/valueThe outcome of the study assists educational institutions and regulatory bodies in framing policies to adapt accounting education to the evolving business landscape by updating the accounting curriculum as per the changes in the market forces to make graduates relevant and competent.
The effect of politically homogenous neighbourhoods on affective polarization: Evidence from Britain
Authors: TILLEY JAMES , HOBOLT SARA B. 
Published: September 2024

AbstractAffective polarization is increasingly evident around the world. This has been attributed in part to residential segregation by partisanship. The ‘Big Sort’ has meant that neighbourhoods in the United States, and elsewhere, have become more homogenous in terms of vote. Yet there is little systematic evidence on the relationship between homogenous partisan neighbourhoods and affective polarization. Does living among fellow partisans make people more negative towards the other side? In this Research Note, we use unique data from Britain to show that while people accurately recognize that their local area is more or less politically homogenous, neighbourhood political homogeneity is not correlated with any measure of affective polarization. These findings are robust to the type of political divide (partisanship or Brexit identity), the level of geography, length of residence and controls for ideology and social characteristics. We therefore suggest that while geographical sorting is an important phenomenon, it is unlikely to be a major cause of affective polarization.
Short‐term germinated legume flours as functional ingredients in food products
Authors: Onwuka Queeneth Ijeoma , Chinma Chiemela Enyinnaya , Ezeocha Vanessa Chinelo , Otegbayo Bolanle , Oyeyinka Samson Adeoye , Adebo Janet Adeyinka , Wilkin Jon , Bamidele Oluwaseun Peter , Adebo Oluwafemi Ayodeji 
Published: September 2024

AbstractUnlocking the potential of legumes through short‐term germination offers an innovative approach to improving the functionality of the resultant flour. This review examines the multifaceted benefits of short‐term germinated legume flour, emphasizing the enzymatic activities that breakdown complex legume compounds into simpler forms and reduce anti‐nutritional factors. This process improves digestibility, nutrient bioavailability, and health‐promoting properties. Furthermore, short‐term germination enhances the techno‐functional properties of legume flours without compromising their quality, avoiding excessive starch and protein degradation associated with prolonged germination. This review also explores the applications of short‐term germinated legume flours in developing nutritious and healthy food products tailored to diverse dietary needs. Subsequent integration of these short‐term germinated flours into food products provides a route for the development of cost‐effective, nutritious, and sustainable options that can address malnutrition and enhance overall well‐being.
Insight into the therapeutic effects of artesunate in relieving metabolic‐associated steatohepatitis from transcriptomic and lipidomics analyses
Authors: Yang Jing , Huang Lei Jie , Ren Tian Yi , Zeng Jing , Shi Yi Wen , Fan Jian Gao 
Published: September 2024

ObjectivesArtesunate (ART) is a water‐soluble derivative of artemisinin, which has shown anti‐inflammatory, anti‐tumor, and immunomodulating effects. We aimed to investigate the potential therapeutic effects and mechanisms of ART in metabolic dysfunction‐associated steatohepatitis (MASH).MethodsThe mice were randomly divided into the control group, high‐fat, high‐cholesterol diet‐induced MASH group, and the MASH treated with ART (30 mg/kg once daily) group. Liver enzymes, lipids, and histological features were compared among groups. The molecular mechanisms were studied by transcriptomic and lipidomics analyses of liver tissues.ResultsThe mice of the MASH group had significantly increased hepatic fat deposition and inflammation in terms of biochemical indicators and pathological manifestations than the control group. The ART‐treated group had improved plasma liver enzymes and hepatic cholesterol, especially at week 4 of intervention (p < 0.05). A total of 513 differentially expressed genes and 59 differentially expressed lipids were identified in the MASH group and the MASH+ART group. Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment test showed that ART regulated glycerolipid metabolism pathway and enhanced fatty acid degradation. Peroxisome proliferator‐activated receptor (PPAR)‐α acted as a key transcription factor in the treatment of MASH with ART, which was confirmed by cell experiment.ConclusionsART significantly improved fat deposition and inflammatory manifestations in MASH mice, with potential therapeutic effects. The mechanism of artemisinin treatment for MASH may involve extensive regulation of downstream genes by upstream transcription factors, such as PPAR‐α, to restore hepatic lipid homeostasis.
Impacts of ecosystem service message framing and dynamic social norms on public support for tropical forest restoration
Authors: Simons D.‐L. , Bradbury R. B. , Evans K. L. 
Published: September 2024

AbstractThe effectiveness of strategic psychology‐based marketing techniques for increasing public support for conservation is poorly understood. We assessed how such techniques affect support for tropical rainforest restoration with a controlled online experiment with 1166 nationally representative residents of the United Kingdom. We tested whether support increased when adding ecosystem service (ES) framings to typical nongovernmental organizations’ (NGOs) biodiversity‐focused messages that emphasize benefits to UK residents or people living near the tropical restoration site and a dynamic social norm nudge that emphasized increasing popularity of environmental restoration. We considered how respondents’ psychological traits (nature connection, self‐efficacy, psychological benefits of supporting charities, awareness of environmental degradation in the Global South, and climate change skepticism) influenced responses. Outcomes included respondents’ reported advertisement sufficiency, sympathetic attitudes, behavioral support, and financial support. The study population typically found advertisements sufficient and exhibited sympathetic attitudes and financial, but not behavioral, support. Younger people exhibited greater conservation support than older respondents. Messages framed solely on biodiversity conservation were as effective as those highlighting additional ES benefits received by UK residents and people near the tropical restoration site. This suggests that framing around ESs, rather than nature's intrinsic value, may not strengthen public support for conservation. The dynamic social norm nudge had perverse effects. It reduced perceived social norms and most outcome variables. Alternative dynamic norm nudges warrant testing, but our results support research suggesting dynamic norm nudges can be ineffective when associated with activism, challenging their use by conservation NGOs. Psychological benefits of supporting charities and perceived self‐efficacy increased support for advertisements, highlighting the benefits of including impact statements relating respondents’ support to specific outcomes. Climate change skepticism decreased support, whereas nature connection and perceived static social norms increased it, highlighting the need to increase nature connection and pro‐environmental social norms to elevate public support for conservation.
Feasibility and safety of endoscopic full‐thickness resection for submucosal tumors in the upper gastrointestinal tract, including predominantly extraluminal submucosal tumors (with video)
Authors: Guo Yingjie , Yin Fan , Qi Xingsi , Zhang Peng , Sun Xueguo , Ding Xueli , Li Xiaoyu , Jing Xue , Jiang Yueping , Tian Zibin , Mao Tao 
Published: September 2024

ObjectivesEndoscopic full‐thickness resection (EFTR) for submucosal tumors (SMTs) has been technically challenging. This retrospective study aimed to evaluate the feasibility, safety, and efficacy of EFTR for upper gastrointestinal (GI) SMTs, including extraluminal lesions.MethodsWe retrospectively investigated 232 patients with SMTs who underwent EFTR from January 2014 to August 2023. Clinicopathologic characteristics, procedure‐related parameters, adverse events (AEs), and follow‐up outcomes were assessed in all patients.ResultsThe en‐bloc resection and en‐bloc with R0 resection rates were 98.7% and 96.1%, respectively. The average endoscopic tumor size measured 17.2 ± 8.7 mm, ranging from 6 to 50 mm. The resection time and suture time were 49.0 ± 19.4 min and 22.5 ± 11.6 min, respectively. In all, 39 lesions (16.8%) exhibited predominantly extraluminal growth. Gastrointestinal stromal tumors (GISTs) were the predominant pathology, accounting for 78.4% of the cases. Twenty‐one patients (9.1%) encountered complications, including pneumothorax (1/232, 0.43%), hydrothorax (1/232, 0.43%), localized peritonitis (3/232, 1.29%), and fever (16/232, 6.9%). Although the incidence of postoperative fever was notably higher in the predominantly extraluminal group (7/39, 17.9%) compared to the predominantly intraluminal group (9/193, 4.7%, P = 0.008), there were no significant differences in outcomes of the EFTR procedure. No instances of recurrence were observed during the mean follow‐up period of 3.7 ± 2.3 years.ConclusionEFTR was found to be feasible, safe, and effective for resecting upper GI SMTs, including lesions with predominantly extraluminal growth. Further validation in a prospective study is warranted.
Maximum mouth opening in patients with cleft lip and palate or craniofacial anomalies compared with non‐affected controls: A cross‐sectional study
Authors: Campbell Richard , Trego Brigitte , Gosnell Elizabeth S. , Fenchel Matthew , Cully Jennifer L. , Wang Jue 
Published: September 2024

AbstractBackgroundThere are limited published data on maximum mouth opening (MMO) for children with cleft lip or palate (CLP) or craniofacial anomalies (CFA).AimTo report MMO of patients with CLP or CFA compared with non‐affected controls.DesignRetrospective cross‐sectional review of electronic medical and dental records. Patients with CLP or CFA with recorded MMO, height, and weight were included and compared with a non‐affected control individuals seen during orthodontic screening. Outcome measures included MMO, recorded in millimeters of inter‐incisal distance, age, height, weight, and sex.ResultsPatients with CLP or CFA (n = 376) were matched by age and body mass standardized index (BMIz) to the non‐affected pool (n = 376). The affected group had a MMO of 43.14 mm (±7.1 mm) compared with the control group MMO of 48.01 mm (±7.6 mm) with a statistically significant difference of −4.86 mm (p < .0001). Specifically, MMO of the unilateral cleft group is 4.26 mm smaller than that of non‐affected controls (p < .0001). MMO of the bilateral cleft group is 3.65 mm smaller than that of non‐affected controls (p = 0.0063).ConclusionsMMO for patients with CLP was significantly smaller as compared to non‐affected controls. This study helps establish MMO values for children with CLP and CFA.
Outcomes of partial pulpotomy in permanent molars of children with irreversible pulpitis: A prospective cohort study
Authors: Zheng Jiajia , Ding Meili , Zhang Shanshan , Ren Yulan , Wen Quan 
Published: September 2024

AbstractBackgroundVital pulp therapy is gaining traction in dental practice, especially for young patients.AimTo evaluate the outcomes of partial pulpotomy in permanent molars of children diagnosed with irreversible pulpitis (IP) using iRoot BP Plus.DesignA total of 94 permanent molars in 88 patients, aged 6–15 years, with symptoms of IP, were treated with partial pulpotomy, using iRoot BP Plus as the pulp capping agent. The treated teeth underwent clinical and radiographic assessments at 1, 6, 12, 18, and 24 months postoperative. The outcomes were determined based on clinical and radiographic criteria by calibrated examiners.ResultsThe success rates were 98.4% (63/64), 93.2% (41/44), and 89.7% (26/29) at the 6‐month, 12‐month, and 24‐month follow‐up. By the end of this study, the median follow‐up period was 15.1 months, and the estimated survival rate was 95.2% at 24 months. Gender, root maturity, and number of missing walls had no significant effect on success rates. Six molars were failed, and root canal therapy (RCT) was applied.ConclusionsPartial pulpotomy for permanent molars with IP in young patients using iRoot BP Plus as pulp capping material achieved high success. This method presents a viable alternative to apexification and RCT for treating vital, inflamed molars with IP in children.
Early sleep apnea treatment in stroke (eSATIS) – a multicentre, randomised controlled, rater‐blinded, clinical trial: The association of post‐stroke cognition with sleep‐disordered breathing and its treatment
Authors: Filchenko Irina , Duss Simone B. , Salzmann Saskia , Brill Anne‐Kathrin , Korostovtseva Lyudmila , Amelina Valeria , Baillieul Sébastien , Bernasconi Corrado , Schmidt Markus H. , Bassetti Claudio L. A. 
Published: September 2024

SummarySleep‐disordered breathing (SDB) is linked to cognitive dysfunction. Although SDB is common in stroke patients, the impact of SDB and its early treatment on cognitive functioning after stroke remains poorly investigated. Therefore, we explored the association between SDB and post‐stroke cognitive functioning, including the impact of early SDB treatment with adaptive servo‐ventilation (ASV) on cognitive recovery from acute event to 3 months post‐stroke. We used data from two studies, which included ischaemic stroke patients (n = 131) and no‐stroke controls (n = 37) without SDB (apnea–hypopnea index, AHI <5/h) and with SDB (AHI≥20/h). Cognitive functioning was assessed within 7 days and 3 months post‐stroke in stroke patients, or at study inclusion in no‐stroke control group, respectively. Stroke patients with SDB were randomized to ASV treatment (ASV+) or usual care (ASV‐). Linear regression adjusted for main confounders assessed the impact of SDB and its treatment on cognitive recovery. The intention‐to‐treat analysis did not show significant associations of SDB ASV+ (n = 30) versus SDB ASV‐ (n = 29) with cognitive recovery. In an exploratory subanalysis, compliant SDB ASV+ (n = 14) versus SDB ASV‐ showed improvements with ASV in visual memory and cognitive flexibility. Combining the stroke and non‐stroke datasets, SDB (n = 85) versus no‐SDB (n = 83) was associated with deficits in visual memory and response inhibition independently of stroke. SDB ASV‐ versus no‐SDB (n = 51) was associated with less improvement in visual memory. There was no substantial evidence for benefits of intention‐to‐treat ASV on cognitive recovery. Exploratory analysis indicated that compliant ASV treatment could benefit visual memory and cognitive flexibility, whereas untreated SDB could contribute to a poor recovery of visual memory.