bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral epithelial cell sheets engraftment for esophageal strictures after endoscopic submucosal dissection of squamous cell carcinoma and airplane transportation
Authors: Yamaguchi Naoyuki , Isomoto Hajime , Kobayashi Shinichiro , Kanai Nobuo , Kanetaka Kengo , Sakai Yusuke , Kasai Yoshiyuki , Takagi Ryo , Ohki Takeshi , Fukuda Hiroko , Kanda Tsutomu , Nagai Kazuhiro , Asahina Izumi , Nakao Kazuhiko , Yamato Masayuki , Okano Teruo , Eguchi Susumu 
Published: December 2017

AbstractEndoscopic submucosal dissection (ESD) permits en bloc removal of superficial oesophageal squamous cell carcinoma (ESCC). However, post-procedure stricture is common after ESD for widespread tumours, and multiple endoscopic balloon dilation (EBD) procedures are required. We aimed to evaluate the safety and effectiveness of endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets that had been transported by air over a distance of 1200 km in controlling postprocedural oesophageal stricture. Ten patients who underwent complete circular or semicircular ESD for ESCC were transplanted with cell sheets. The safety of the entire process including cell sheet preparation, transport, ESD and cell sheet transplantation was assessed. The incidence of oesophageal stricture, number of EBD sessions, and time until epithelialization were investigated. Each ESD was successfully performed, with subsequent cell sheet engrafting carried out safely. Following cell sheet transplantation, the luminal stenosis rate was 40%, while the median number of EBD sessions was 0. The median post-ESD ulcer healing period was rather short at 36 days. There were no significant complications at any stage of the process. Cell sheet transplantation and preparation at distant sites and transportation by air could be a safe and promising regenerative medicine technology.
Short Physical Performance Battery for cardiovascular disease inpatients: implications for critical factors and sarcopenia
Authors: Yasuda Tomohiro , Nakajima Toshiaki , Sawaguchi Tatsuya , Nozawa Naohiro , Arakawa Tomoe , Takahashi Reiko , Mizushima Yuta , Katayanagi Satoshi , Matsumoto Kazuhisa , Toyoda Shigeru , Inoue Teruo 
Published: December 2017

AbstractWe examined the relationship between Short Physical Performance Battery (SPPB) and clinical and laboratory factors and the effect of sarcopenia and sarcopenic obesity (SO) on clinical and laboratory factors for cardiovascular disease (CVD) inpatients. CVD male (n = 318) and female (n = 172) inpatients were recruited. A stepwise multiple-regression analysis was performed to predict total SPPB scores and assess clinical and laboratory factors (physical characteristics, functional and morphological assessments, etc.). Each test outcome were compared among sarcopenia, SO and non-sarcopenic groups. To predict total SPPB scores, the predicted handgrip, Controlling Nutritional Status score, % body fat, anterior mid-thigh muscle thickness, standing height and systolic blood pressure were calculated for males and anterior mid-thigh MTH, BMI, knee extension and fat mass were calculated for females. There were no differences in blood pressure, total SPPB scores and functional assessments between sarcopenia and SO groups for CVD male and female inpatients. In conclusion, the physical performance of CVD inpatients can be predicted by nutritional, functional, clinical and anthropometric variables, regardless the gender and the presence of sarcopenia. Furthermore, the presence of sarcopenia has a negative effect on the clinical and laboratory factors, but there is a difference in impact between sarcopenia and SO regardless the gender.
The feasibility of low-concentration contrast and low tube voltage in computed tomography perfusion imaging: an animal study
Authors: Pan Yuning , Song Aiqin , Bu Shizhong , Chen Zhaoqian , Huang Qiuli , Li Aijing 
Published: December 2017

Aim: To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging.
Method: A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan. The obtained images were reconstructed with filtered back projection (FBP) and AIDR-3D in the control and experimental groups respectively. The perfusion parameters (hepatic artery perfusion [HAP], portal vein perfusion [PVP], hepatic perfusion index [HPI], and total liver perfusion [TLP]) and image quality (image quality score, average CT value of abdomen aorta, signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], and figure of merit [FOM]) were compared using a paired t-test or Mann–Whitney U test between the two groups, when appropriate. The effective radiation dose and iodine intake were also recorded and compared.
Results: With the exception of the FOM criteria, the image quality and perfusion parameters were not significantly different between the two groups. The effective radiation dose and iodine intake were 38.79% and 27.03% lower respectively, in the experimental group.
Conclusion: Low-concentration contrast (iodixanol, 270 mg/ml) together with low tube voltage (80 kV) and AIDR-3D reconstruction help to reduce radiation dose and iodine intake without compromising perfusion parameters and image quality in liver CT perfusion imaging.
Headphone Evaluation for App-Based Automated Mobile Hearing Screening
Authors: Pickens Adam , Robertson Lakshmi , Smith Matthew , Zheng Qi , Song Sejun 
Published: December 2017

Introduction With the need for hearing screenings increasing across multiple populations, a need for automated options has been identified. This research seeks to evaluate the hardware requirements for automated hearing screenings using a mobile application.
Objective Evaluation of headphone hardware for use with an app-based mobile screening application.
Methods For the purposes of this study, hEAR, a Bekesy-based mobile application designed by the research team, was compared with pure tone audiometric tests administered by an audiologist. Both hEAR and the audiologist's test used 7 frequencies (125 Hz, 250 Hz, 500 Hz, 1,000 Hz, 2000 Hz, 4,000 Hz and 8,000 Hz) adopting four different sets of commercially available headphones. The frequencies were regarded as the independent variable, whereas the sound pressure level (in decibels) was the dependent variable. Thirty participants from a university in Texas were recruited and randomly assigned to one of two groups, whose only difference was the order in which the tests were performed. Data were analyzed using a generalized estimating equation model at α = 0.05.
Results Findings showed that, when used to collect data with the mobile app, both the Pioneer HDJ-2000 (Pioneer, Bunkyo, Tokyo, Japan) (p > 0.05) and the Sennheiser HD280 Pro (Sennheiser, Wedemark, Hanover, Germany) (p > 0.05) headphones presented results that were not statistically different from the audiologist's data across all test frequencies. Analyses indicated that both headphones had decreased detection probability at 4kHz and 8kHz, but the differences were not statistically significant.
Conclusion Data indicate that a mobile application, when paired with appropriate headphones, is capable of reproducing audiologist-quality data.
Periocular Cutaneous Mucormycosis Caused by Saksenaea erythrospora
Authors: Putthirangsiwong Bunyada , Mahaisavariya Pornchai , Chokthaweesak Weerawan , Selva Dinesh 
Published: December 2017

Abstract
Saksenaea erythrospora is a rare pathogen in humans. Ten adult cases have been previously reported, eight manifested with cutaneous infection, and two presented with invasive rhinosinusitis infection. The authors present a 16-month-old boy with progressive painful mass at the right medial canthus and upper cheek that was unresponsive to broad-spectrum antibiotics. He underwent an anterior orbitotomy and biopsy. Histopathology revealed broad nonseptate sterile hyphae and grew S. erythrospora, which was confirmed by molecular techniques. The patient was treated with intravenous liposomal amphotericin B and oral itraconazole combined with aggressive surgical debridement. The patient made a complete recovery without long-term complications at 4 months of follow-up. Primary cutaneous mucormycosis caused by S. erythrospora may rarely involve the periocular region and mimic chronic dacryocystitis. We report the first case of pediatric periocular cutaneous mucormycosis caused by S. erythrospora.
Lower prevalence of vitamin D insufficiency in German patients with systemic mast cell activation syndrome compared with the general population
Authors: Wirz Stefan , Hertfelder Hans-Jörg , Seidel Holger , Homann Jürgen , Molderings Gerhard 
Published: December 2017

Abstract
Introduction The common mastocytosis variant systemic mast cell activation syndrome (MCAS) may underlie at least a subset of patients with irritable bowel syndrome (IBS). A critical role of vitamin D (VD) in the stabilization of mast cells (MCs) with deficiency of VD resulting in MC activation has been demonstrated. If so, supplementation of VD would be a potential therapeutic approach in the treatment of those IBS patients.
Methods We investigated in the present study for the first time systematically whether the VD level in 100 MCAS patients differed from that in the German general population (Ggp) and made a first attempt to elucidate potential reasons for possible differences by simultaneously determining the blood levels of heparin and cholesterol.
Results In contrast to the Ggp, the VD level was detected in a sufficient range (> 30 ng/mL) in 53 % of the MCAS patients (Ggp 8 %), and only 34 % had values in the range of deficiency (< 20 ng/mL; GgP 75 %). There was no correlation between VD blood level and heparin and cholesterol blood levels.
Conclusions The demonstration that in the majority of MCAS patients the VD level is not in a deficient range argues against an essential contribution of VD deficiency to the high prevalence of MCAS in Germany. Our findings do not exclude the possibility of smaller effects of VD level on MC activation in vivo. However, if such effects are present, the effect sizes seem to be too small to become identifiable in the multifactorial process of disease development.
Isogloiosiphone B, a novel acetal, and hydrophobic compounds as β-glucuronidase inhibitors derived from the red alga Neodilsea yendoana
Authors: Zhang Duo , Kurihara Hideyuki 
Published: December 2017

Abstract
A novel acetal named isogloiosiphone B was isolated from the red alga Neodilsea yendoana, along with three known hydrophobic compounds as β-glucuronidase inhibitors. The acetal was determined as a naturally occurring compound from the extraction experiments with several kinds of solvent. The acetal showed the highest inhibition against β-glucuronidase among the compounds examined.
First synthesis of (S)-(+)-hymenoic acid, a DNA polymerase λ inhibitor isolated from Hymenochaetaceae sp
Authors: Takahashi Kensuke , Matsui Miki , Kuse Masaki , Takikawa Hirosato 
Published: December 2017

Abstract
Hymenoic acid, isolated from cultures of the fungus, Hymenochaetaceae sp., is a specific inhibitor of DNA polymerase λ. The first synthesis of (S)-(+)-hymenoic acid was achieved by starting from trans-1,4-cyclohexanedimethanol and methyl (R)-(−)-3-hydroxyisobutyrate, and Julia–Kocienski olefination was employed as the key step.
Enhancement of natural killer activity and IFN-γ production in an IL-12-dependent manner by aBrassica rapaL.
Authors: Yamamoto Kana , Furuya Kanon , Yamada Kazuki , Takahashi Fuka , Hamajima Chisato , Tanaka Sachi 
Published: December 2017

AbstractCertain food components possess immunomodulatory effects. The aim of this study was to elucidate the mechanism of the immunostimulatory activity of Brassica rapa L. We demonstrated an enhancement of natural killer (NK) activity and interferon (IFN)-γ production in mice that were orally administered an insoluble fraction of B. rapa L. The insoluble fraction of B. rapa L. significantly induced IFN-γ production in mouse spleen cells in an interleukin (IL)-12-dependent manner, and NK1.1+ cells were the main cells responsible for producing IFN-γ. Additionally, the results suggested that the active compounds in the insoluble fraction were recognized by Toll-like receptor (TLR) 2, TLR4, and C-type lectin receptors on dendritic cells, and they activated signaling cascades such as MAPK, NF-κB, and Syk. These findings suggest that B. rapa L. is a potentially promising immuno-improving material, and it might be useful for preventing immunological disorders such as infections and cancers by activating innate immunity.
Legal Rhetoric and the Ambiguous Shape of the King’s Two Bodies in Calvin’s Case (1608)
Authors: Franz Margaret 
Published: December 2017

ABSTRACT
This essay examines how Francis Bacon’s speech in Calvin’s Case (1608) and Edward Coke’s report on the case engage with the doctrine of the king’s two bodies. While both texts portray the subject as perpetually obligated to the king’s personal body, the ambiguity of the doctrine combined with the topical resources of early-modern legal rhetoric allowed for disparate constructions of the king’s two bodies that could at once support and displace the absolute sovereignty of the king’s personal body. In the end, I argue that both texts offer distinct contributions to the early-modern era’s budding anti-royalist discourse.
Aristotle’s Rhetorical Energeia: An Extended Note
Authors: Westin Monica 
Published: December 2017

ABSTRACT
In Book III of the Rhetoric, Aristotle focuses at length on the effect of lexical energeia. Scholarship on energeia in this passage almost always associates it with with analysis of enargeia in later texts. However, it is not clear that these two are used as equivalents in Aristotle. Here I survey Aristotle’s conceptions of energeia across the corpus in order to understand Aristotle’s use of energeia in the Rhetoric more precisely. I argue that Aristotle’s model of energeia has a consistent fundamental meaning, even as it crosses many topoi, and that Aristotle’s rhetorical energeia cannot be conflated with enargeia.
Introduction
Authors: Beaney Michael 
Published: December 2017

Abstract
One claim often made about analytic philosophy is that it places great emphasis on clarity of thinking, precision of expression, and rigour of argumentation. But other intellectual virtues that might be considered are creativity, fruitfulness, and systematicity. The Introduction aims to give some sense of the conceptual creativity of analytic philosophy and the bigger picture in which its fruitfulness and systematic ambitions can be appreciated. Analytic philosophy is called ‘analytic’ because of the emphasis placed on analysis. But this just raises the question of what is meant by ‘analysis’, and what forms of analysis are employed in analytic philosophy. This is best answered by considering a range of philosophical questions.
How can we speak of what does not exist?
Authors: Beaney Michael 
Published: December 2017

Abstract
Statements that purportedly refer to something that does not exist, whether fictional or not, have been especially problematic in the history of philosophy. ‘How can we speak of what does not exist?’ suggests that in order to understand existential statements, we need to recall Frege’s claim that number statements are assertions about concepts. Existential statements are really just a type of number statement. When we make an existential claim, we are not attributing a first-level concept to an object, but a second-level concept to a first-level concept. The work of Bertrand Russell (1872–1970) is also discussed along with the Russell Paradox and his Theory of Descriptions.
Are there limits to what we can say or think?
Authors: Beaney Michael 
Published: December 2017

Abstract
‘Are there limits to what we can say and think?’ considers the possible limits of our language and whether we can have thoughts that outstrip our ability to say what they are. It introduces Ludwig Wittgenstein (1889–1951), arguably the greatest philosopher of the 20th century, and his publication, Tractatus Logico-Philosophicus (1921), which describes his philosophical ideas. The paradox of inference is discussed along with how Wittgenstein distinguishes between senselessness and nonsense. It concludes that there are indeed limits to what we can say or think, and while there may be difficulties in saying what they are, they can certainly be shown by carefully elucidating the complex workings of language.
So what is analytic philosophy?
Authors: Beaney Michael 
Published: December 2017

Abstract
There are various similarities and differences between the respective approaches to analytic philosophy of Frege, Russell, Moore, Wittgenstein, and Stebbing. But is there anything in common that could be taken to characterize analytic philosophy as a whole? ‘So what is analytic philosophy?’ explains that analytic philosophy is ‘analytic’ in an extra special sense because it made use of modern logic together with all the new techniques that emerged in its wake and the greater understanding of the relationship between logic and language that this generated. It looks at later analytic philosophy—ordinary language philosophy, ideal language philosophy, and scientific philosophy—before considering what is wrong and good about analytic philosophy.
The Role of a Neuropsychologist on a Movement Disorders Deep Brain Stimulation Team
Authors: Kubu Cynthia S 
Published: December 2017

Abstract
The term movement disorders is misleading in the implication that the symptoms are limited to motor problems. Most movement disorders include a variety of neurobehavioral and neurocognitive symptoms that require neuropsychological expertise. The goal of this paper is to provide a rationale and practical roadmap for neuropsychologists’ involvement in a Movement Disorders team with a specific focus on pre-operative deep brain stimulation (DBS) evaluations. Pragmatic recommendations regarding requisite skills, clinical practice, recommendations, communication, and benefits are outlined.
Identifying the subtle signatures of feedback from distant AGN using ALMA observations and the EAGLE hydrodynamical simulations
Authors: Scholtz J , Alexander D M , Harrison C M , Rosario D J , McAlpine S , Mullaney J R , Stanley F , Simpson J , Theuns T , Bower R G , Hickox R C , Santini P , Swinbank A M 
Published: December 2017

AbstractWe present sensitive 870 μm continuum measurements from our ALMA programmes of 114 X-ray selected active galactic nuclei (AGN) in the Chandra Deep Field-South and Cosmic Evolution Survey fields. We use these observations in combination with data from Spitzer and Herschel to construct a sample of 86 X-ray selected AGN, 63 with ALMA constraints at z = 1.5–3.2 with stellar mass &gt;2 × 1010 M⊙. We constructed broad-band spectral energy distributions in the infrared band (8–1000 μm) and constrain star-formation rates (SFRs) uncontaminated by the AGN. Using a hierarchical Bayesian method that takes into account the information from upper limits, we fit SFR and specific SFR (sSFR) distributions. We explore these distributions as a function of both X-ray luminosity and stellar mass. We compare our measurements to two versions of the Evolution and Assembly of GaLaxies and their Environments (EAGLE) hydrodynamical simulations: the reference model with AGN feedback and the model without AGN. We find good agreement between the observations and that predicted by the EAGLE reference model for the modes and widths of the sSFR distributions as a function of both X-ray luminosity and stellar mass; however, we found that the EAGLE model without AGN feedback predicts a significantly narrower width when compared to the data. Overall, from the combination of the observations with the model predictions, we conclude that (1) even with AGN feedback, we expect no strong relationship between the sSFR distribution parameters and instantaneous AGN luminosity and (2) a signature of AGN feedback is a broad distribution of sSFRs for all galaxies (not just those hosting an AGN) with stellar masses above ≈1010 M⊙.
Isolated Absent Thelarche in a Patient With Neurofibromatosis Type 1 and Acromegaly
Authors: Martini Anne E. , Zolton Jessica R. , DeCherney Alan H. 
Published: December 2017

BACKGROUND:
Isolated absent thelarche is a rare condition that is infrequently reviewed in the literature.

CASE:
A 28-year-old woman with neurofibromatosis type 1 and acromegaly presented with absent breast development despite hormone therapy. Examination noted a normally developed woman with acromegalic features and Tanner stage I breasts. Hormone studies and karyotype were normal. Magnetic resonance imaging of the patient's brain demonstrated a voluminous pituitary. Chromosome microarray analysis diagnosed the neurofibromatosis 1 microdeletion syndrome. Breast ultrasonography and surgical consultation were offered.

CONCLUSIONS:
Neither neurofibromatosis type 1, acromegaly, nor neurofibromatosis 1 microdeletion syndrome are linked to absent thelarche. After attempting hormone therapy, patients with absent thelarche should be evaluated for congenital breast anomalies, estrogen receptor abnormalities, or gene defects. Psychological and surgical consultation should also be offered.
Intrauterine Balloon Tamponade for Severe Postpartum Hemorrhage
Authors: Revert Mathilde , Rozenberg Patrick , Cottenet Jonathan , Quantin Catherine 
Published: December 2017

OBJECTIVE:
To compare the rates of invasive procedures (surgical or vascular) for hemorrhage control between a perinatal network that routinely used intrauterine balloon tamponade and another perinatal network that did not in postpartum hemorrhage management.

METHODS:
This population-based retrospective cohort study included all women (72,529) delivering between 2011 and 2012 in the 19 maternity units in two French perinatal networks: a pilot (in which balloon tamponade was used) and a control network. Outcomes were assessed based on discharge abstract data from the national French medical information system. General and obstetric characteristics were included in two separate multivariate logistic models according to the mode of delivery (vaginal and cesarean) to estimate the independent association of the network with invasive procedures.

RESULTS:
Invasive procedures (pelvic vessel ligation, arterial embolization, hysterectomy) were used in 298 women and in 4.1 per 1,000 deliveries (95% CI 3.7–4.6). The proportion of women with at least one invasive procedure was significantly lower in the pilot network (3.0/1,000 vs 5.1/1,000, P<.01). Among women who delivered vaginally, the use of arterial embolization was also significantly lower in the pilot than the control network (0.2/1,000 vs 3.7/1,000, P<.01) as it was for those who delivered by cesarean (1.3/1,000 vs 5.7/1,000, P<.01). After controlling for potential confounding factors, the risk of an invasive procedure among women who delivered vaginally remained significantly lower in the pilot network (adjusted odds ratio [OR] 0.14, 95% CI 0.08–0.27), but not for women who delivered by cesarean (adjusted OR 1.19, 95% CI 0.87–1.61).

CONCLUSION:
The use of intrauterine balloon tamponade in routine clinical practice was associated with a significantly lower use of invasive procedures for hemorrhage control among women undergoing vaginal delivery.