bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Rose Oxide and Exercise Synergistically Modulate Cardiovascular and Autonomic Functions in Hypertensive Rats
Authors: Silva Juliana A. da , Araújo Samuel S. P. , Silva Ana Flávia M. da , de Assunção José Guilherme V. , Santos Pâmela S. , Júnior José L. P. , Reis Carlos Eduardo S. , Santana Liana M. , Silva Regina G. , Oliveira Ariell A. , Nunes Francisca V. Sousa , Oliveira Aldeidia P. , Sousa Damião P. , Soriano Renato N. , Branco Luiz G. S. , Salgado Helio C. , Sabino João Paulo Jacob 
Published: October 2024

Abstract

With the alarming rise in cases of arterial hypertension worldwide, there is an urgent need to develop combined therapies to mitigate this scenario. Rose Oxide (RO), a monoterpene with anti-inflammatory and hypotensive properties, emerges as an alternative. The present study is the first to evaluate the effect of RO administered chronically and combined with physical exercise (swimming) since both have been reported to have beneficial impacts on hypertension. Male SHR and Wistar rats (aged 12 weeks) received RO for 34 consecutive days (orally; 100 mg/kg). The progression of systolic blood pressure (SBP) was monitored through tail-cuff plethysmography. Twenty-four hours before the end of the treatment, the animals were anesthetized, and the femoral artery and vein were cannulated to record the pulsatile arterial pressure and to administer drugs, respectively. Hemodynamic and autonomic parameters and baroreflex sensitivity and intrinsic heart rate (IHR) were evaluated. Treatment with RO, administered alone or combined with exercise, reduced SBP and mean arterial pressure in SHR. The swimming protocol did not prevent increases in BP, but when combined with RO, it improved autonomic control, assessed through heart rate variability and parasympathetic tone. IHR was attenuated in SHR, and none of the treatments reversed this response. Therefore, combining RO with physical exercise may enhance their antihypertensive effects, improving autonomic function, reducing oxidative stress and inflammation, providing synergistic cardiovascular benefits, improving metabolic health, promoting a comprehensive lifestyle intervention, and potentially allowing for reduced medication dosages. This multifaceted approach could offer a more effective and sustainable strategy for managing hypertension.
Delineation of reduced CTV2 based on the characteristics and distribution of cervical lymph node metastasis in nasopharyngeal carcinoma
Authors: Wang Zhiqiang , Yang Yi , Ge Chunlei , Tian Rui , Cheng Sheng , Gao Jingyu , Wang Yan , Yue Qi , Wang Zhiwei , He Qingqing , Xu Yuchuan , Li Yan , Feng Xudong , Yang Yanli , Zhang Yong 
Published: October 2024

Abstract

Introduction: To accurately locate each metastatic lymph node, identify potential areas for exemption from radiotherapy in patients with NPC, and assess the dosimetric difference in OARs between reduced-target radiotherapy and conventional radiotherapy.
Methods and Materials: A total of 209 patients were included to analyze the pattern and distribution characteristics of cervical lymph node metastasis. Thirty patients with NPC were randomly selected for reduced CTV2 radiotherapy through a lottery system. The variation in doses to the OARs was evaluated in different cohorts.
Results: A total of 2314 metastatic lymph nodes were identified and mapped. There were no metastatic lymph nodes observed at level VIIb and within the lateral border of the common carotid artery. The percentages of metastatic lymph nodes at levels Ⅰa, Ⅰb, Ⅱa, Ⅱb, Ⅲ, Ⅳa, Ⅳb, Ⅴa, Ⅴb, Ⅴc, Ⅵa, Ⅵb, Ⅶa, Ⅶb and Ⅷ accounted for 0%, 1.5%, 22.8%, 41.1%, 15.9%, 3.0%, 0%, 4.4%, 1.0%, 0.3%, 0%, 0%, 9.7%, 0% and 0.3%, respectively, of the 2314 metastatic lymph nodes. Further analysis of dosimetric outcomes revealed a significantly lower mean dose to the oral cavity, laryngeal cavity, esophagus, trachea, pharyngeal constrictor muscles, parotid gland, submandibular gland and thyroid gland with the implementation of reduced-target radiotherapy than with standard radiotherapy.
Conclusion: IMRT sparing level Ⅰa, Ⅰb, Ⅳb, Ⅵ, and Ⅶb lymph nodes and the area within the lateral border of the common carotid artery is feasible in NPC patients.
A multi-omics analysis of CSF reveals the differential immunopathology molecular mechanisms underlying viral encephalitis and autoimmune encephalitis
Authors: Zhu Kun , Lin Ke , Shen Feifei , Zhang Haocheng , Zhang Yi , Deng Bo , Xue Quanlin , Guo Jingxin , Wu Qian , Ai Jingwen , Chen Xiangjun , Zhang Wenhong 
Published: October 2024

Abstract

Background: This study explores viral encephalitis (VE) and autoimmune encephalitis (AE), similar in symptoms but requiring distinct treatments. Early diagnosis is crucial for effective intervention. The research utilizes early cerebrospinal fluid (CSF) analysis, employing transcriptomics, proteomics, and metabolomics to understand the immunological aspects of VE and AE.
Methods: Participants from the IMPROVE clinical trial (ClinicalTrial.gov, NCT04946682, July 1, 2021) between April 2018 and November 2022 were included. CSF samples at disease onset were analyzed for VE and AE immunological profiles.
Results: CSF analysis from 34 VE patients, 29 AE patients, and 6 controls unveiled shared and distinct immune mechanisms. Compared to controls, VE and AE patients showed reduced neuronal transporter functions and increased T and B cell activation. VE exhibited heightened interferon responses, complement pathways, and CD8+ T cell functions. AE displayed unique modulations in CD4+ T cell and Treg cell activities, potentially reducing autoimmune responses. Both conditions induced damage to critical brain areas.
Conclusion: The study identified immunological differences and similarities, emphasizing specific CSF molecular changes for differential diagnosis. Findings highlighted complex immune interactions, with both diseases involving suppressed neuronal functions and heightened T and B cell activities. VE featured distinct interferon and CD8+ T cell activations, while AE showed specialized CD4+ T and Treg cell modulations. Immune balance played a crucial role in encephalitis pathogenesis. Further studies are crucial to validate biomarkers for accurate diagnosis, paving the way for targeted therapies and improved management of these neurological disorders.
Identifying Key Factors for Recurrence of Genetic Disorder: Insights from Indian Families with Multiple Affected Children
Authors: Menon Kriti , Agarwal Vani 
Published: October 2024

Abstract

This study investigates the factors contributing to the recurrence of severe genetic conditions in multiple children of the same couple, focusing on a cohort of 26 families who had more than one child affected by the same genetic disorder. Conducted at a genetic clinic in India, the study employed a qualitative methodology guided by COREQ guidelines, using semi-structured interviews to explore the interplay of individual beliefs, healthcare provider practices, and systemic healthcare inefficiencies. The interviews were transcribed and analyzed using a combination of content analysis and grounded theory, which allowed for the identification of recurrent themes and emerging ideas. The study found that strong religious and cultural beliefs often led families to disregard medical advice, contributing to the recurrence of genetic conditions. Additionally, significant gaps in healthcare provider knowledge and inadequate reproductive counseling were identified as critical barriers to timely diagnosis and prevention of recurrence. Another major theme was the inherent complexities of genetic diseases and genetic testing, where variable expression of conditions, delayed symptom onset, and limitations of genetic tests themselves often prevented early diagnosis and intervention. This research highlights the need for improved genetic literacy among healthcare providers, culturally sensitive counseling, and better integration of genetic services into the broader healthcare system. By addressing these barriers, the risk of recurrence can be significantly reduced, improving patient outcomes and family well-being. This study is one of the few in India to analyze such factors and underscore the critical need for targeted interventions at multiple levels.
The prevalence of myopia and eye-related behavior among 3 to 18 years: a cross-sectional survey study
Authors: Tian Lu , Zhu Mengxia , Song Yuhan , Wang Yin , Jiang Yan 
Published: October 2024

Abstract

Aims
To determine the current status of myopia and the relationship between eye-related behaviors and myopia in children and adolescents aged 3 to 18 years.
Methods
A total of 3240 children and adolescents from 15 schools were selected for the survey between January and June 2024 in Hubei Province, China. A stratified random cluster sampling method was employed for the collection of samples. All participants were requested to complete the Eye-Related Behavior Assessment Scale for Kindergarten and Primary School Students in Grades 1-3-Parent Version (ERBAS-P) and the Eye-Related Behavior Assessment Scale for Primary School Students in Grades 4–6 and Middle School Students-Student Version (ERBAS-S) on line. Data on socio-demographic factors (gender, grades, region) and myopia rate were collected.
Results
The overall prevalence of myopia among children and adolescents aged 3–18 years in Hubei Province was 34.35%. Risk of myopia was higher in females than in males (OR = 1.27, P = 0.007), in rural than in urban areas (OR = 1.88, P < 0.001), and in children with myopic parents than with non-myopic parents (OR = 3.21, P < 0.001). Furthermore, of the 3240 participants, only 18.1% (n = 587) had good eye-related behavior levels, 46.1% (n = 1494) had moderate eye-related behavior levels, and the rest had poor levels, and there was a significantly higher risk of myopia for poor compared to good eye-related behavior levels (OR = 1.74, P < 0.001). The regression analysis showed that the level of eye-related behavior varied significantly with many of the demographic variables particularly with grades group, gender and whether myopia.
Conclusion
The prevalence of myopia is at a high level among individuals between the ages of 3 and 18 in Hubei province, China, with notable differences between urban and rural populations. The level of eye-related behavior among children and adolescents is suboptimal. A particular focus on fostering the development of positive eye-use habits among younger children should be reinforced in the future.
Corneal Endothelial Damage Following FS-LASIK Combined with Corneal Cross-Linking Surgery: Case Report With Literature Review
Authors: Wang Li , Zhang Xiaofeng 
Published: October 2024

Abstract

Purpose: To report a case of early corneal endothelial damage in a patient with high myopia after undergoing FS-LASIK combined with corneal cross-linking.
Case Description: An observational case report of an 18-year-old male patient with high myopia who underwent FS-LASIK combined with corneal cross-linking. On the third day postoperatively, slit lamp examination revealed corneal edema in the right eye, small pit-like lesions on the endothelial surface of both eyes, and a significant drop in endothelial cell count and percentage of hexagonal cells compared to preoperative levels. One week postoperatively, corneal edema in the right eye and small pits on the endothelial surface of both eyes disappeared, and the number and area of dark spots significantly reduced. At two months postoperatively, the visual acuity of both eyes was 20/20, and the dark spots on the endothelial surface disappeared, the corneal endothelial cell count, the percentage of hexagonal cells, and the coefficient of variation in cell size returned to preoperative levels.
Conclusion: We report a case of early, reversible endothelial damage following FS-LASIK combined with corneal cross-linking.
The role of information processing as an underlying mechanism in the experience of anxiety reactivity and anxiety perseveration; two dissociable dimension of trait anxiety.
Authors: Moore Sophia , Dondzilo Laura , Mazidi Mahdi , MacLeod Colin , Notebaert Lies 
Published: October 2024

Abstract

Purpose.
While long considered a unitary dimension, research has moved towards a multidimensional understanding of trait anxiety. Most relevant to this study, is the conceptualisation of two dissociable dimensions of trait anxiety; anxiety reactivity and anxiety perseveration. Despite the consolidation of this understanding over the past decade, the mechanisms underlying these two dimensions are not well established. The present study examined the novel role of information processing in the experience of anxiety reactivity and perseveration, specifically, how enhanced processing of situational information influences reactivity, and how enhanced processing of implicational information influences perseveration.
Method.
Undergraduate university students (N = 142) completed an experimental session, where they encountered an interview-based stressor. As participants approached this stressor, they were provided with information reflecting one of the two content categories, intended to encourage a situational or implicational processing mode. To facilitate measurement of anxiety reactivity and anxiety perseveration, state anxiety was assessed at crucial junctures across the experimental session.
Results.
Our findings did not provide evidence for the role of enhanced processing of situational information in the experience of anxiety reactivity, nor the role of enhanced processing of implicational information in the experience of anxiety perseveration. An experimental manipulation involving valence revealed that receiving positive information reduced the intensity of state anxiety elevations, in the aftermath of the information processing task.
Conclusions.
Findings are discussed with reference to limitations and future extensions that could investigate the potential role of cognitive biases in this proposed relationship between enhanced information processing and anxiety reactivity and perseveration.
The association between neutrophil percentage and albumin ratio and early deterioration of neurological function after thrombolysis in acute ischemic stroke patients
Authors: Song Hui , Song Guijun 
Published: October 2024

Abstract

Aim
To investigate the correlation between neutrophil percentage to albumin ratio (NAPR) and early deterioration of neurological function after intravenous thrombolysis in acute ischemic stroke patients.
Methods
A retrospective analysis was conducted on 322 acute ischemic stroke patients who received intravenous thrombolysis at the Second Affiliated Hospital of Dalian Medical University from January 2021 to May 2024. 39 patients who experienced early neurological function deterioration (END) after ateplase thrombolysis, while the control group consisted of 283 patients whose symptoms improved after intravenous thrombolysis,we called early neurological improvement(ENI).Collect baseline data and blood parameters for statistical analysis.
Results
Compared with the control group, patients with higher initial NIHSS scores and NPAR had a higher incidence of early END after using thrombolysis (p = 0.041; P < 0.001).
Conclusion
NPAR is associated with early neurological deterioration after intravenous thrombolysis in acute ischemic stroke. Patients with higher NPAR are more prone to occur early neurological deterioration. NPAR is a cost-effective and useful biomarker for predicting early neurological deterioration in patients with acute ischemic stroke after intravenous thrombolysis.
Effectiveness of Educational Intervention for Improving Monkeypox Viral Infection Knowledge in MSM Population
Authors: Wu Xueer , Xu Yuanyuan , Li Xin , Ding Songning , Hu Yang , Zhu Zhengping 
Published: October 2024

Abstract

Background
Monkeypox is a zoonotic disease caused by the monkeypox virus, which has recently exhibited human-to-human transmission globally. Due to its hidden nature and high-risk behaviors, men who have sex with men (MSM) has become a focal point for monkeypox prevention and control. This study evaluates the impact of health interventions on monkeypox knowledge awareness among MSM.
Methods
Through pre- and post-MIP surveys, we analyzed the awareness of monkeypox knowledge, preferences for acquiring monkeypox information, and preferred channels among MSM. Data collection occurred from August 2023 to March 2024, with a total of 1,514 valid questionnaires collected. The Mpox Intervention Program (MIP) included the development and distribution of educational materials, Voluntary Counseling and testing (VCT) clinic consultations, and surveys.
Results
Post-intervention, the total score for monkeypox knowledge awareness significantly increased from 58.50 to 68.47 (P < 0.001), and the knowledge awareness rate rose from 48.66–64.60% (P < 0.001). The intervention significantly improved participants' understanding of monkeypox incubation period, asymptomatic infections, transmission routes, and prevention measures (P < 0.001). MSM preferred obtaining monkeypox knowledge through new media and internet social platforms, with no significant changes in preferences pre- and post-MIP.
Conclusion
The MIP effectively improved monkeypox knowledge awareness and cognitive levels among MSM. These findings provide scientific evidence for optimizing health education strategies and controlling the spread of monkeypox.
Identification and Diagnostic Significance of MPO, PRTN3, and CTNND1 as Biomarkers in Acute Hematogenous Osteomyelitis in Children: A Comprehensive Analysis Using Machine Learning Algorithms
Authors: Yang Jia , Zhang Tianjiu , Chen Kezhi , Luo Jihang , Yu Song 
Published: October 2024

Abstract

Background
Acute hematogenous osteomyelitis (AHO) is a severe bacterial bone infection predominantly affecting children. Early diagnosis is crucial to prevent the progression to chronic osteomyelitis. However, current diagnostic methods are limited in sensitivity and specificity, underscoring the need for reliable biomarkers.
Methods
This study utilized gene expression data from the Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs) associated with AHO. We employed three machine learning algorithms—The Least Absolute Shrinkage and Selection Operator (LASSO) regression, Support Vector Machine-Recursive Feature Elimination (SVM-RFE), and Random Forest (RF)—to screen for potential diagnostic markers. The expression levels of key genes were validated using clinical samples from pediatric AHO patients. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic accuracy of these biomarkers.
Results
Our analysis identified five candidate genes, among which Myeloperoxidase (MPO), Serum proteinase 3 (PRTN3), Catenin delta 1 (CTNND1) were significantly associated with AHO, MPO and PRTN3 were upregulated, while CTNND1 was downregulated in AHO samples compared to healthy controls. ROC curve analysis demonstrated that CTNND1 (AUC = 0.8832), MPO (AUC = 0.9803) and PRTN3 (AUC = 0.9767) exhibited strong diagnostic potential. Importantly, the expression levels of MPO and PRTN3 positively correlated with disease severity as classified by the Cierny-Mader staging system, whereas CTNND1 expression showed a negative correlation.
Conclusion
MPO, PRTN3, and CTNND1 are promising biomarkers for the diagnosis and monitoring of AHO in children. Their expression levels correlate with disease severity, making them valuable tools for assessing the progression and treatment efficacy in pediatric AHO. Further research is warranted to explore their potential in clinical applications.
The effects of Self-care, Self-efficacy, and Health Literacy on Health-related Quality of Life in Patients with Hypertension
Authors: Salmanpour Nastaran , Salehi Alireza , Nemati Sadaf , Rahmanian Mahdi , drissi Hamed Bazrafshan , Shadzi Mohammad Reza , Zakeri Alireza 
Published: October 2024

Abstract

Background: Hypertension is a chronic disease that can deteriorate patients' health-related quality of life (Hr-QoL). In this study, we aim to investigate the variables associated with Hr-QoL, including self-care, self-efficacy, and health literacy in patients with hypertension.
Methods: In this cross-sectional study, data on 427 randomely selected patients from March 2023 to March 2024 in community and private sectors were collected through interviews in different clinics affiliated with Shiraz University of Medical Sciences, Shiraz, Iran. A linear regression model was used for multivariate data analysis.
Results: The mean age of the participants in the study was 60.05± 11.06, and most (68.4%) were women. The mean total Hr-QoL, self-care, self-efficacy and health literacy scores were 62.47%±15.75, 87.14%±10.76, 68.69%±14.90, and 81.15% ± 17.19, respectively. Based on the linear regression model, every one score change in self-care total score, self-efficacy total score, and health literacy total score was associated with -0.471 (CI:-0.792 - -0.150), 0.306 (CI:0.140-0.473), and 0.283(CI:0.206-0.360) change in Hr-QoL total score, respectively. The model also demonstrated that having an occupation and good income was associated with 7.415 (CI:4.262-10.568) and 6.330 (CI:3.818-8.843) more Hr-QoL scores, respectively. Also, patients who did not have diabetes mellitus and renal disease had 3.407 (CI:0.802-6.012) and 4.071 (CI:1.109-7.032) more Hr-QoL scores, respectively—based on the model, health literacy (β=0.375) had the strongest effect on the Hr-QoL.
Conclusion: In conclusion, self-care, self-efficacy, and health literacy can positively predict Hr-QoL in patients with hypertension. Moreover, health literacy is the strongest predictive factor of Hr-QoL in patients with hypertension.
Distinctive Features of Bimanual Coordination in Idiopathic Normal Pressure Hydrocephalus
Authors: Umemori Takuma , Kobayashi Kazushige , Watanabe Ryo , Higuchi Takahiro 
Published: October 2024

Abstract

Background
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by cerebrospinal fluid circulation disorders, and presents as gait and balance disturbances similar to those observed in other incurable neurological diseases. Although previous studies have reported deficits in bimanual coordination among patients with iNPH, these potential pathological characteristics have not received much attention to date. This study investigated the temporal characteristics of a bimanual finger-tapping task in patients with iNPH, focusing on within- and between-hand coordination.
Methods
Study participants comprised three groups: patients with iNPH (N = 19, mean age = 76.9 ± 5.6 years), older adults (N = 19, 76.4 ± 5.3 years), and younger adults (N = 13, 32.2 ± 8.5 years). Participants performed a bimanual finger-tapping task under five conditions that manipulated the temporal differences between the two taps.
Results
The iNPH group exhibited significantly greater errors in both within- and between-hand coordination tasks compared to the other two groups.
Conclusion
The observed increase in errors in between-hand coordination in the older group compared to the younger group, suggests that between-hand coordination is susceptible to aging. These findings show that evaluating temporal errors in a bimanual coordination task, particularly for within-hand coordination, is potentially useful for uncovering pathological characteristics specific to iNPH.