bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finished Genome Sequence of the Highly Multidrug-Resistant Human Urine Isolate Citrobacter freundii Strain SL151
Authors: Leski Tomasz A. , Taitt Chris R. , Bangura Umaru , Ansumana Rashid , Stenger David A. , Wang Zheng , Vora Gary J. 
Published: November 2016

ABSTRACTCitrobacter freundiiis a Gram-negative opportunistic pathogen that is increasingly being recognized as a causative agent of hospital-acquired urinary tract infections and an important reservoir of antimicrobial resistance determinants. In this report, we describe the finished genome sequence ofC. freundiistrain SL151, a highly multidrug-resistant human urine isolate.
The role of buoyancy reversal in turbidite deposition and submarine fan geometry
Authors: Steel Elisabeth , Buttles James , Simms Alexander R. , Mohrig David , Meiburg Eckart 
Published: November 2016

Abstract
Although recent work has shown that changing interstitial fluid density within turbidity currents is a frequently overlooked factor affecting the texture and internal architecture of turbidites, little is known about its influence on submarine fan morphology. Here we present the results of three-dimensional flume experiments of turbidity currents that clearly demonstrate the role of low-density interstitial fluid, in combination with sediment concentration and basin gradient, on submarine fan geometry. The experiments show that turbidity currents with reversing buoyancy, and their resulting deposits, are narrower than those that remain ground hugging. Furthermore, wider deposits result from increases in sediment concentration and/or basin-floor gradient. We also propose that Taylor-Görtler vortices associated with currents traveling over a break in slope may lead to the deposition of wider lobes compared with those traveling over a constant gradient.
Rates of glaucomatous visual field change after trabeculectomy
Authors: Baril C , Vianna J R , Shuba L M , Rafuse P E , Chauhan B C , Nicolela M T 
Published: November 2016

BackgroundTrabeculectomy is frequently performed in patients with glaucoma who are deteriorating, although its effects on rates of visual field (VF) progression are not fully understood. We studied the rate of VF progression post trabeculectomy comparing with medically treated patients matched for VF loss.MethodsMedical records of patients who underwent trabeculectomy alone or combined with cataract extraction were reviewed. Patients with 5 or more 24–2 VF examinations post trabeculectomy were selected. The rate of mean deviation (MD) change after surgery was calculated for each patient. These patients were pairwise matched based on baseline MD with patients with glaucoma who were treated medically and had at least 5 VF tests.Results180 surgical patients were identified and matched with 180 medically treated patients (baseline MD of −8.72 (5.24) dB and −8.71 (5.22) dB, respectively). Surgically and medically treated patients were followed for 7.4 (2.9) and 6.8 (3.1) years respectively. The MD slopes were −0.22 (0.55) dB/year and −0.08 (1.10) dB/year in the surgically and medically treated patients, respectively, and not statistically different (p=0.13, 95% CI −0.31 to 0.04). More patients in the surgical group had fast progression (rates worse than −1 dB/year) than in the medical group (17 and 7 patients, respectively, p=0.05).ConclusionsOur findings suggest that most patients who undergo trabeculectomy demonstrate relatively slow rates of VF progression postoperatively, similar to patients treated medically, although some patients can continue to progress despite adequate surgical control of intraocular pressure.
A standardized neurointerventional thrombectomy protocol leads to faster recanalization times
Authors: Frei Donald , McGraw Constance , McCarthy Kathryn , Whaley Michelle , Bellon Richard J , Loy David , Wagner Jeff , Orlando Alessandro , Bar-Or David 
Published: November 2016

Background and purposeIntra-arterial therapy (IAT) is most effective when performed rapidly after ischemic stroke onset. However, there are limited performance benchmarks in IAT and there is a scarcity of information on how to structure an effective IAT protocol and its impact on time to treatment. The objective of our study was to detail a standardized IAT protocol, and to assess its influence on time to treatment in ischemic stroke.MethodsThis was a retrospective observational study over 4 years at a comprehensive stroke center. A standardized IAT protocol was implemented in June 2013 that included pre-notifying the stroke team before hospital arrival, defining clinician roles, processing tasks in parallel, and standardizing IAT procedures. Three time metrics were examined and reported as median (IQR) minutes: arrival to CT imaging, CT to groin puncture, and puncture to recanalization. We compared these metrics in patients admitted before implementation (January 2012–May 2013) to patients admitted after (June 2013–December 2015) using Wilcoxon Mann–Whitney tests.Results380 patients were included. After the protocol was implemented, there were significant reductions in time from arrival to CT (17 (14–21) vs 13 (11–19) min, p<0.001), CT to puncture (46 (30–82) vs 31 (23–54) min, p<0.001), and puncture to recanalization (65 (33–90) vs 37 (22–65) min, p<0.001). 60% of time was saved during puncture to recanalization. Significant reductions in time were observed during both normal working hours and off-hours.ConclusionsImplementation of a standardized protocol resulted in a significant reduction in time to recanalization for patients with an ischemic stroke. A standardized IAT protocol decreases time to recanalization when team roles are clearly defined, tasks are processed in parallel, and procedures are standardized.
Efficacy of endovascular treatment and feasibility of stent-assisted coiling in the presence of severe and symptomatic vasospasm
Authors: Andic Cagatay , Kardes Ozgur , Durdag Emre , Gedikoglu Murat , Akin Sule 
Published: November 2016

Background and purposeIn patients with aneurysmal subarachnoid hemorrhage, deciding the optimal treatment strategy is challenging in the presence of severe and symptomatic vasospasm and the existing literature is limited. The purpose of this study was to evaluate the safety and effectiveness of endovascular treatment of intracranial aneurysms and the feasibility of stent-assisted coiling during severe and symptomatic vasospasm.Materials and methodsFifteen consecutive patients with 18 aneurysms who underwent endovascular treatment during severe and symptomatic vasospasm were included in the study. Patient and aneurysm characteristics, treatment technique, and clinical and angiographic outcomes were retrospectively evaluated.ResultsAneurysms were treated by the following techniques: single catheter coiling in 9, stent-assisted coiling in 8 (3 aneurysms with Y-configuration double stents), and balloon-assisted coiling in 1. All patients showed angiographic improvement of vasospasm after treatment including a noticeable dilation of the spastic parent arteries following deployment of the stents. According to the immediate post-treatment angiography results, 14 aneurysms (77.8%) had class I occlusion and 4 (22.2%) had class II occlusion. Three patients died during the course of subarachnoid hemorrhage. Mortality was related to the poor grade (Hunt and Hess grade V) and cardiovascular complications in two and refractory vasospasm one patient. The remaining patients had favorable clinical outcomes at follow-up (modified Rankin Scale 0–2).ConclusionsEndovascular treatment of intracranial aneurysms during severe and symptomatic vasospasm is safe and effective. Stent-assisted coiling in the presence of severe vasospasm is also feasible in wide-necked aneurysms with the additional benefits of mechanical vasodilation.
Comparison of the use of LigaSure versus a standard technique for tonsillectomy in dogs
Authors: Belch A. , Matiasovic M. , Rasotto R. , Demetriou J. 
Published: November 2016

The principal aim of this study was to document the effectiveness of tonsillectomy in dogs using a vessel‐sealing device compared with a standard technique with tonsillectomy forceps. A secondary aim of the study was to document histopathological changes of the excised tonsillar tissue in dogs with brachycephalic obstructive airway syndrome. 20 dogs were studied. The time taken to remove a tonsil using LigaSure was a mean of 44.8 seconds (sd 15 seconds, 95 per cent CI 40 to 57 seconds) and with the standard technique a mean of 305.9 seconds (sd 67 seconds, 95 per cent CI 272 to 349 seconds). Significantly less haemorrhage occurred using LigaSure compared with the standard technique. Histopathology of the tonsils was characterised by multifocal neutrophilic and lymphocytic inflammation, and 1–2 mm of heat‐induced coagulation necrosis at the cut edge of LigaSure tonsils. This study shows that LigaSure is significantly faster and resulted in less bleeding than the standard technique.
The LHC searches for heavy neutral Higgs bosons by jet substructure analysis
Authors: Chen Ning 
Published: November 2016

The two-Higgs-doublet model contains extra Higgs bosons with mass ranges spanning from several hundred GeV to about 1 TeV. We study the possible experimental searches for the neutral Higgs bosons of [Formula: see text] and [Formula: see text] at the future high-luminosity LHC runs. Besides of the conventional search modes that are inspired by the supersymmetric models, we discuss two search modes which were not quite addressed previously. They are the decay modes of [Formula: see text] and [Formula: see text]. Thanks to the technique of tagging boosted objects of SM-like Higgs bosons and top quarks, we show the improved mass reaches for heavy neutral Higgs bosons with masses up to [Formula: see text]. The modes proposed here are complementary to the conventional experimental searches motivated by the MSSM.
Laboratory experiments on bentonite pellet saturation
Authors: Trpkošová Dagmar , Večerník Petr , Gondolli Jenny , Havlová Václava , Svoboda Jiří , Hanusová Irena 
Published: November 2016

Abstract

The aim of the DOPAS project is to address the design basis, reference designs and strategies for the plugs and seals to be used in geological disposal facilities. The Czech ‘Experimental Pressure and Sealing Plug’ (EPSP) experiment has the following objectives: to develop, monitor and verify the functionality of an
in situ
experimental plug, and to determine and describe in detail the materials to be used with respect to experimental plug construction. The functionality of the experimental plug will be verified by means of conducting pressure tests after the construction phase of EPSP. The internal bentonite section of the EPSP will be constructed from bentonite pellets with a dry density of 1850 kg m
−3
; the pellets will disintegrate following saturation and swelling to form a homogeneous material with a dry density of around 1400 kg m
−3
. This process leads to the question of the pore space of the bentonite material: that is, whether it will be possible to employ a numerical model for homogeneous compacted bentonite powder porosity instead of that of the double pore/void space of the bentonite pellets used in the experiment. For this reason, a laboratory physical model (PHM – physical hydraulic model) was incorporated into the DOPAS project for the purpose of describing the saturation and disintegration of the bentonite pellets. The aim of this paper is to describe the results of the space distribution of relative humidity in a sample consisting of bentonite pellets with a view to subsequent numerical modelling and to extend the current knowledge concerning the behaviour of the bentonite pellets used in the EPSP experiment. The results show that following water saturation and the swelling of the bentonite the pellets form a homogeneous mass in the same way as does the compacted bentonite powder. After a period of 160 days, the pellets attained 100% relative humidity at a distance of 12.5 cm and swelling pressure recorded at the end of the model was seen to slowly increase over this time period.
HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib
Authors: Press Michael F. , Ellis Catherine E. , Gagnon Robert C. , Grob Tobias J. , Buyse Marc , Villalobos Ivonne , Liang Zhiyong , Wu Shafei , Bang Yung-Jue , Qin Shu-Kui , Chung Hyun Cheol , Xu Jianming , Park Joon Oh , Jeziorski Krzysztof , Afenjar Karen , Ma Yanling , Estrada Monica C. , Robinson Douglas M. , Scherer Stefan J. , Sauter Guido , Hecht J. Randolph , Slamon Dennis J. 
Published: November 2016

Abstract
HER2/ERBB2 status is used to select patients for HER2-targeted therapy. HER2/ERBB2 amplification/overexpression of upper gastrointestinal (UGI) adenocarcinomas was determined locally or in two central laboratories to select patients for the TRIO-013/LOGiC trial of chemotherapy with or without lapatinib. Patients selected locally had central laboratory confirmation of HER2 amplification for inclusion in the primary efficacy population. HER2 was assessed with PathVysion or IQ PharmDx FISH and HercepTest immunohistochemistry assays. Associations with outcomes were retrospectively evaluated. Overall, HER2 status was determined in UGI cancers from 4,674 patients in a central laboratory for eligibility (1,995 cases) and for confirmation of local HER2 results (333 cases). Of 1,995 adenocarcinomas screened centrally, 322 (16.1%) had HER2-amplified disease with 29 (1.5%) showing HER2 genomic heterogeneity. Men and older patients had higher rates of amplification. Of 545 patients accrued to the trial (gastric, 87.3%; GEJ, 8.3% and esophageal cancer, 4.4%), 487 patients (89%) were centrally confirmed as having HER2-amplified disease. Concordance between central and local HER2 testing was 83%. Concordance between PathVysion and IQ PharmDx FISH assays was 99% and FISH in the two central laboratories was 95%. Lapatinib-treated Asian participants and those less than 60 years had significant improvement in progression-free survival (PFS), particularly among those whose cancers had 5.01–10.0 and &gt;10.0-fold amplification of HER2. In conclusion, HER2 is commonly amplified in UGI adenocarcinomas with amplification highly correlated to overexpression, and HER2 amplification levels correlated with PFS. While HER2 genomic heterogeneity occurs, its prevalence is low. Mol Cancer Ther; 16(1); 228–38. ©2016 AACR.
Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities
Authors: Talbert Erin E. , Yang Jennifer , Mace Thomas A. , Farren Matthew R. , Farris Alton B. , Young Gregory S. , Elnaggar Omar , Che Zheng , Timmers Cynthia D. , Rajasekera Priyani , Maskarinec Jennifer M. , Bloomston Mark , Bekaii-Saab Tanios , Guttridge Denis C. , Lesinski Gregory B. 
Published: November 2016

Abstract
Involuntary weight loss, a part of the cachexia syndrome, is a debilitating comorbidity of cancer and currently has no treatment options. Results from a recent clinical trial at our institution showed that biliary tract cancer patients treated with a MEK inhibitor exhibited poor tumor responses but surprisingly gained weight and increased their skeletal muscle mass. This implied that MEK inhibition might be anticachectic. To test this potential effect of MEK inhibition, we utilized the established Colon-26 model of cancer cachexia and the MEK1/2 inhibitor MEK162. Results showed that MEK inhibition effectively prevented muscle wasting. Importantly, MEK162 retained its ability to spare muscle loss even in mice bearing a Colon-26 clone resistant to the MEK inhibitor, demonstrating that the effects of blocking MEK are at least in part independent of the tumor. Because single-agent MEK inhibitors have been limited as a first-line targeted therapy due to compensatory activation of other oncogenic signaling pathways, we combined MEK162 with the PI3K/Akt inhibitor buparlisib. Results showed that this combinatorial treatment significantly reduced tumor growth due to a direct activity on Colon-26 tumor cells in vitro and in vivo, while also preserving skeletal muscle mass. Together, our results suggest that as a monotherapy, MEK inhibition preserves muscle mass, but when combined with a PI3K/Akt inhibitor exhibits potent antitumor activity. Thus, combinatorial therapy might serve as a new approach for the treatment of cancer cachexia. Mol Cancer Ther; 16(2); 344–56. ©2016 AACR.
See related article by Kobayashi et al., p. 357
Comparison Between 1- and 2-Stent Strategies in Unprotected Distal Left Main Disease
Authors: Takagi Kensuke , Naganuma Toru , Chieffo Alaide , Fujino Yusuke , Latib Azeem , Tahara Satoko , Ishiguro Hisaaki , Montorfano Matteo , Carlino Mauro , Kawamoto Hiroyoshi , Kurita Naoyuki , Hozawa Koji , Nakamura Shotaro , Nakamura Sunao , Colombo Antonio 
Published: November 2016

Background—
There are only little data available on the comparison of clinical outcomes between a 1-stent strategy (1-SS) and a 2-stent strategy (2-SS) for percutaneous coronary intervention in unprotected distal left main disease.

Methods and Results—

Between April 2005 and August 2011, we recruited 937 consecutive unprotected distal left main patients treated with drug-eluting stents (1-SS, 608 patients; 2-SS, 329 patients). Major adverse cardiovascular events were defined as all-cause death, myocardial infarction, or target lesion revascularization (TLR) during the median follow-up period of 1592 days. Furthermore, the individual components of major adverse cardiovascular events, cardiac death, and stent thrombosis were evaluated. More complex lesions were seen with 2-SS than with 1-SS. Cardiac death occurred more frequently with 1-SS than with 2-SS (propensity score–adjusted hazard ratio, 0.52; 95% confidence interval, 0.29–0.64;
P
=0.03), whereas TLR occurred more frequently with 2-SS than with 1-SS (propensity score–adjusted hazard ratio, 1.59; 95% confidence interval, 1.15–2.20;
P
=0.005). TLR was mainly driven by revascularizations after restenosis at the ostial left circumflex artery (propensity score–adjusted hazard ratio, 1.94; 95% confidence interval, 1.33–2.82;
P
=0.001). However, there were no differences in major adverse cardiovascular events, all-cause death, stent thrombosis, and myocardial infarction. Of the 139 pairs that were propensity score matched, only TLRs were significantly higher in the 2-SS group (hazard ratio, 1.59; 95% confidence interval, 1.00–2.53;
P
=0.05).

Conclusions—
The difference between 1-SS and 2-SS in percutaneous coronary intervention for unprotected distal left main disease may be summarized by the high incidence of TLR, mainly because of restenosis at the ostial left circumflex artery in the 2-SS group.
The NOAA FM-CW Snow-Level Radar
Authors: Johnston Paul E. , Jordan James R. , White Allen B. , Carter David A. , Costa David M. , Ayers Thomas E. 
Published: November 2016

AbstractA vertically pointing radar for monitoring radar brightband height (BBH) has been developed. This new radar utilizes frequency-modulated continuous wave (FM-CW) techniques to provide high-resolution data at a fraction of the cost of comparable pulsed radars. This S-band radar provides details of the vertical structure of precipitating clouds, with full Doppler information. Details of the radar design are presented along with observations from one storm. Results from a calibration using these storm data show the radar meets the design goals. Eleven of these radars have been deployed and provide BBH data in near–real time.
Effects of the FIFA 11 training program on injury prevention and performance in football players: a systematic review and meta-analysis
Authors: Gomes Neto Mansueto , Conceição Cristiano Sena , de Lima Brasileiro Alécio Jorge Alves , de Sousa Camila Santana , Carvalho Vitor Oliveira , de Jesus Fabio Luciano Arcanjo 
Published: November 2016

Objective: To investigate the effects of FIFA 11 training on injury prevention and performance in football players. Design and methods: Systematic review and meta-analysis. We conducted a systematic search using four databases (CINAHL, Cochrane Library, EMBASE, and PubMed) to find controlled trials evaluating the effects of FIFA 11 on injury prevention and performance among football players. Weighted mean differences, standard mean differences, risk ratios, and 95% confidence intervals were calculated, and heterogeneity was assessed using the I2 test. Results: We analyzed 11 trials, including 4700 participants. FIFA 11 resulted in a significant reduction in injury risk (risk ratio = 0.69; 95% confidence interval, 0.49–0.98; P = 0.02) and improvements in dynamic balance (weighted mean difference = 2.68; 95% confidence interval, 0.44–4.92; P = 0.02) and agility (standard mean difference = −0.36; 95% confidence interval, 0.70–0.02; P = 0.04). The meta-analysis indicated a non-significant improvement in jump height (standard mean difference = 0.25; 95% confidence interval, 0.08–0.59; P = 0.14) and running sprint (standard mean difference = −0.24; 95% confidence interval, 0.58–0.10; P = 0.17) in the FIFA 11 group. Conclusions: FIFA 11 can be considered as a tool to reduce the risk of injury. It may improve dynamic balance and agility and can be considered for inclusion in the training of football players.
Cervical cancer incidence in British Columbia: Predicting effects of changes from Pap to human papillomavirus screening and of changes in screening participation
Authors: Coldman Andrew , van Niekerk Dirk , Smith Laurie , Ogilvie Gina 
Published: November 2016

Objectives To estimate the impact of increased participation in screening, and of the proposed change from Pap to human papillomavirus screening on the incidence of cervical cancer in British Columbia. Methods For invasive cervical cancer cases diagnosed in British Columbia between 2002 and 2011, data were extracted on age and cancer morphology from the British Columbia Cancer Registry, and Pap screening history was obtained from the British Columbia Cervical Cancer Screening Program database. Only screening performed two to seven years prior to diagnosis was assumed to reduce subsequent risk of cancer. Results from randomized trials of human papillomavirus versus cytology screening and population based estimates of cytology screening were used to estimate the effect of a change in screening test and increases in participation. Results Between 2002 and 2011, there were 1663 cases of cervical cancer reported; 660 (367 squamous and 293 non-squamous) were eligible and screened two to seven years prior to diagnosis. The predicted reduction by changing to human papillomavirus screening was 363 (95% confidence interval = 124–496) representing 22% of all cases. If 50% of subjects not screened two to seven years prior had undergone Pap screening, it is projected that a further 268 cases (16%) could have been prevented; if they had undergone human papillomavirus screening, a further 365 cases (22%) could have been prevented. Conclusions For many women who develop cervical cancer, primary human papillomavirus testing could have substantially reduced their cancer risk. Human papillomavirus rather than Pap testing would further increase the gains from any increases in population screening participation.