bluuebunny/crossref_metadata_2025_split huggingface dataset:
La incidencia del estrés en el ámbito laboral
Authors: Calvo Lugo Juan Manuel 
Published: October 2024

Este artículo tiene como objetivo investigar el impacto del estrés laboral en la salud y el bienestar de los trabajadores dentro de una organización, para ello, se llevó a cabo un análisis exhaustivo que abordó la prevalencia del estrés laboral en el entorno actual, así como sus raíces subyacentes y las repercusiones en el rendimiento de los empleados. El estudio se basó en una revisión sistemática de información obtenida de libros, tesis y artículos publicados de prestigiosas bases de datos como Scielo, Scopus, Latindex y el Fondo Editorial San Marcos, donde se analizaron un total de 25 artículos relevantes sobre el tema. Así, se identificaron distintas categorías de análisis, incluyendo factores estresantes laborales, consecuencias y estrategias para que las organizaciones puedan contribuir a reducirlo. Los objetivos que motivan esta investigación son la evaluación de los impactos del estrés laboral, identificar los factores que contribuyen a su aparición, qué consecuencias existen y la importancia de adoptar enfoques preventivos en el entorno laboral. Los resultados indicaron que los factores que contribuyen al estrés son, principalmente, las exigencias y tensiones laborales, la carga laboral y la falta de control, las condiciones de trabajo desfavorables y el ambiente laboral; en conclusión, se encontró que existen prácticas empresariales que pueden reducir los niveles de estrés, entre las cuales están la implementación de programas de bienestar, la flexibilidad laboral, los reconocimientos y recompensas adecuados, la capacitación y el monitoreo continuo, así como la retroalimentación.
Old believers in the 20th century of Lithuania
Authors: Potašenko Grigorijus 
Published: October 2024

This article is a short study of Church history of Old Believers, of relation between Old Believers Church and state in the independence Lithuania (1918-1940), Poland (district of Vilnius), and in Soviet Lithuania (1940-1941, 1944-1990). In the second half of the 17th century, Old Believers settlements were organized in Great Duke of Lithuania. After World War I, 35,000 Old Believers inhabited the Lithuanian republic. In 1922, Old Believers subordinated their communities to the Centrai Council of Old Beliefs Church in Lithuania in the matters of faith. Old Believers were recognized by the Lithuanian state as a separate persuasion. In the forties of the 20th century, there were 54 communities of Old Believers in Lithuania. In 1925, the First Congress of Polish Old Believers convened. The Congress agreed upon the official name of Old Believers – Pomortsy – Eastern Old Belief Church without ecclesiastic hierarchy. The organization of the Church and the internal statute was resolved. In 1928, Old Believers were recognized by the state as a separate persuasion. Generally, before World War II, over 50,000 Old Believers inhabited Poland. During World War II, some of the Old Believers joined the Red Army, others joined the underground army. Many Old Believers stayed in Lithuania. The Nazis deported some of them to forced labor camps. In the time of the war, some oratories were destroyed, and some Old Believers died. In 1987, there were 54 communities of Old Believers in Lithuania. Between 1944-1988, three Congresses of Old Belief Pomorskaya Church were held here. The High Council of Old Believers was the only religious-spiritual center of bespopovtsy pomortsy in the Soviet Union (till 1990).
Efficacy and Safety of Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke: A Systematic Review and Meta-analysis
Authors: Tugade Reynald Evan R , David Billy Joseph B , Tolentino Clara S 
Published: October 2024

Introduction: Stroke remains a major cause of morbidity and mortality after cardiac surgery. One factor associated with stroke occurrence is postoperative AF (pAF), which predisposes to the formation of atrial thrombus. As most thrombi form in the left atrial appendage (LAA), there is significant interest in LAA as a potential therapeutic target. While guidelines recommend direct oral anticoagulants (DOACs) as the preferred therapy for stroke prevention in patients with AF and a CHA2DS2-VASc score of ≥2, they cannot be administered to all patients who are poor candidates for long-term oral anticoagulation because of the high risk of bleeding, drug compliance and drug tolerance. There are limited data on the efficacy and safety of LAA occlusion (LAAO) during cardiac surgery for stroke prevention. Methods: A comprehensive and relevant search of randomised controlled trials, cohort and case–control studies was conducted. Outcome measures for ischaemic stroke events, all-cause mortality and pAF were extracted and analysed using a random-effects model. Results: Twelve studies were included and 18,982 subjects were analysed. There were 231 ischaemic stroke events in 9,473 patients who received LAAO compared with 371 ischaemic stroke events in 9,509 patients who did not receive LAAO. Concomitant LAAO showed a significant difference in ischaemic event rate (risk ratio [RR] 0.65; [95% CI: 0.55–0.77]; p<0.00001, I2=0%) and all-cause mortality (RR 0.74; 95% CI [0.57–0.97]; p=0.03; I2=68%). For pAF, there was no difference between the two groups (RR 1.08; 95% CI [0.95–1.22]; p=0.24; I2=72). Conclusion: Concomitant LAAO was more effective in preventing ischaemic stroke events and all-cause mortality, with an overall moderate certainty of evidence. However, pAF rates were similar between LAAO and non-LAAO groups.
Enhancement of processed cheese quality using ultrasound: energy density optimization and industrial applications
Authors: A. Alsaleem Khalid 
Published: October 2024

This study examined the impact of varying ultrasound energy densities on the functional properties of processed cheese with different levels of emulsifying salt (0%, 0.5%, 1%, 2%, or 3% disodium phosphate). The mixtures were ultrasonicated at 65 watts and 160 watts for either 3 min or 9 min, producing energy densities of 58.5 J/g, 175.5 J/g, 144 J/g, and 432 J/g. The rheological and textural properties of the processed cheese were evaluated at these energy densities and compared to a control sample. At 432 J/g, cheese with 1% emulsifying salt was cooked whereas cheese at 58.5 J/g, 175.5 J/g, and 144 J/g did not cook with the emulsifying salt levels of 1% or lower. There was no significant difference (p > 0.05) in hardness and melting temperature between cheese having the energy density of 432 J/g and processed with 1% and 2% emulsifying salt. Additionally, no significant difference (p > 0.05) was observed in the functional properties of cheese across different energy density treatments. The functional properties of the processed cheese improved significantly with increased emulsifying salt levels. This study suggests that using 432 J/g of ultrasound energy can effectively reduce the requirement of emulsifying salts in the cheese industry.
Ficción autobiográfica: Parler-trans
Authors: Combative Tak 
Published: October 2024

En este escrito se pretende dar sentido al término “escritura autobiográfica trans” o “parler-trans” y su estudio. Para esto, se considera la historia de la narración autobiográfica, empezando por la escritura tradicional masculina y pasando luego por la transgresión de la escritura femenina. Frente a dicha revisión, se sostiene que la escritura masculina y femenina no son las únicas dos opciones posibles dentro de la ficción autobiográfica y se presenta luego lo que será denominado parler-trans. Las preguntas principales que guían esta indagación son: ¿Qué significa la existencia del parler-trans? ¿Qué rasgos distintivos podría tener? ¿Cuáles son sus similitudes con la escritura masculina y femenina?
La transacción erótica como empoderamiento del sujeto queer caribeño en Sirena Selena vestida de pena, de Mayra Santos Febres
Authors: Rozo Juan Carlos 
Published: October 2024

Este artículo explora la novela Sirena Selena vestida de pena, de Mayra Santos Febres y la relación que se establece entre su protagonista, un travesti puertorriqueño, y Hugo Graubel, un empresario dominicano. Propongo que el vínculo, inicialmente una transacción erótica bajo el control de Graubel, deviene un juego de inversión de poderes en el que la sexualidad de Sirena Selena obliga a Graubel a transgredir sus estatutos performativos y perder el poder que devenga como agente hegemónico. Así, la transacción erótica, que a primera vista no atenta contra las convenciones sociales ni sexuales de la sociedad caribeña, funge también como espacio de empoderamiento del sujeto queer, a través de la transgresión y la rearticulación identitarias.
Desplazamientos e inversiones en La Habana para un infante difunto de Guillermo Cabrera Infante
Authors: M. Martínez Elena 
Published: October 2024

Este trabajo analiza La Habana para un infante difunto (1979) de GuillermoCabrera Infante (1929-2005) desde la perspectiva del género sexual. Se presta atención a la operación paródica y desestabilizadora en la conformación autorreflexiva del narrador, pícaro intelectual que se desenvuelve en un ambiente marcado por la homosociabilidad y la compulsión heterosexual. Valiéndose de los planteamientos teóricos de género de Rafael Ramírez, Luce Irigaray y Teresa de Lauretis, en un primer momento se consideran losdesplazamientos e inversiones que se dan en la construcción de la masculinidad.En un segundo momento se estudia la representación misógina de los personajes femeninos y la dinámica entre el protagonista y sus amantes.
Electrochemical sensor for the detection of serine β-lactamase catalytic activity
Authors: Shumyantseva Victoria V. , Bulko Tatiana V. , Presnova Galina V. , Grigorenko Vitaly G. , Rubtsova Maya Yu. 
Published: October 2024

A new approach is proposed based on the use of electrodes modified with carbon nanomaterials to determine enzymatic activity and screening for inhibitors of serine β-lactamases such as extended spectrum β-lactamases (ESBLs). These enzymes are responsible for the development of antibiotic resistance of pathogenic bacteria to β-lactam antibiotics. Electrochemical oxidation of cephalosporin antibiotic cefotaxime was effectively registered at a potential E from +596 to +625 mV (relative to Ag/AgCl). This property makes it possible to determine the change in cefotaxime concentration in solution upon interaction with serine β-lactamases. By analyzing the electrochemical characteristics of the cefotaxime oxidation reaction, the kinetic parameters of its hydrolysis catalyzed by the serine β-lactamase CTX-M-116 were determined. The Michaelis constant was KM = 50 µM and the maximum rate of the catalytic reaction was 1.67∙10–6 M/min. A comparative analysis of the electrochemical parameters of the enzyme/substrate cefotaxime and enzyme/substrate cefotaxime/inhibitor sulbactam (SBT) systems was carried out. Inhibition of β-lactamase by sulbactam was characterized by an IC50 value of 2.5 μM. The proposed approach can be used for screening new substrates and inhibitors of β-lactamases.
Análise da variabilidade na precipitação pluvial ao longo de um século em Cajazeiras-PB
Authors: Medeiros Everton de Araújo , Silva José Erivaldo da , Dantas Janaina Lucio , Silva Madson Tavares , Junior Fabíola de Leonardo Souza do Prado , Maracaja Patricio Borges , Ribeiro , George do Nascimento 
Published: October 2024

Este artigo apresenta uma análise da variabilidade da precipitação da cidade de Cajazeiras, no estado da Paraíba ao longo de uma série histórica no período de 1911 a 2022, a fins de verificar tendências de aumento ou diminuição das precipitações, para isto, faz-se uso da aplicação do teste de Mann-Kendall e teste de Pettitt com dados obtidos pela Agencia Nacional de Águas (ANA), Superintendência do Desenvolvimento do Nordeste (SUDENE) e da Agencia Executiva de Gestão das Águas no Estado da Paraíba (AESA), a análise foi realizada em escalas de décadas, anuais, mensais e diárias. Os resultados mostram um aumento da precipitação em média e de eventos extremos diários de precipitação pluvial, levantando uma reflexão sobre importância de caracterizar uma serie longa para compreender melhor as variações da chuva em áreas semiáridas e como os resultados podem contribuir com a gestão dos recursos hídricos por parte dos agentes público e pelo melhor aproveitamento do recurso pela população local.
High Expression of Immune Checkpoint Molecules in Different Types of Thyroid Cancer
Authors: Shacker Mahdi Sajedi , Dehghanian Amir Reza , Kiani Razie , Haghshenas Mohammad Reza , Erfani Nasrollah 
Published: October 2024

This study aimed to investigate the expression of programmed cell death protein-1 (PD-1) and its ligand (PD-L1) immune checkpoint molecules in thyroid carcinomas and determine their association with the clinicopathological characteristics of patients.
Thyroid tissue specimens from 100 patients diagnosed with primary thyroid carcinomas including papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC) were collected. Sections were prepared from formalin-fixed paraffin-embedded samples, and PD-1 and PD-L1 expressions were examined using immunohistochemistry.
PD-1 was detected in tumor-infiltrating lymphocytes (TILs) in 88% of the patients and tumor cells in 28% of the patients with 10% in PTC, 5% in FTC, 5% in MTC, and 8% in ATC). PD-L1 was found in tumor cells and TILs in 30% and 79% of the patients, respectively. Moreover, a significant difference was observed in PD-1 and PD-L1 expression between tumor cells and TILs across different tumor types. However, their expression in tumor cells and TILs was significantly higher in ATC compared to other tumor types. Additionally, the expression of PD-1 and PD-L1 was significantly associated with an advanced stage, higher tumor size, tumor necrosis, and mitosis. A significant positive correlation was also observed between the expression of PD-1 and PD-L1 in tumor cells and TILs.
The higher expression of PD-1 and PD-L1 may contribute to tumor progression. Therefore, combinational immunotherapy by these immune checkpoint inhibitors might be a promising strategy for clinical improvement in patients with thyroid cancer, especially those with ATC.
Up-Regulation of miR-625-5p Correlates with Suppressed Sox2, Increased Apoptosis, and Cell Cycle Arrest via The PI3K/AKT Signalling Pathway in Acute Myeloid Leukaemia
Authors: Kereka Kangup Steven , Mousavi Seyed Hadi , Alizadeh Shaban , Ghaemmaghami Leila , Fakoorizad Ghasem , Motallebzadeh Khanmiri Jamal 
Published: October 2024

Background: Up-regulation of the microRNA-625 and abnormal expression of the Sox2 gene have been studied and seen in several tumors. Few reports have also shown the aberrant expression of miR-625 and Sox2 expression in various cancers. Several studies have also confirmed that phosphatidylinositol 3' -kinase /protein kinase B pathways regulate hematological malignancies, including Acute Myeloid Leukemia (AML). Thus, this study aimed to investigate the effects of mir-625 up-regulation on proliferation, apoptosis, and cell cycle by targeting the Sox2 gene via the downstream Akt signaling pathway and cell cycle regulators, such as p21, p27, and cyclin E in the KG-1 cell line.
Materials and Methods: Cells obtained from the KG-1 cell line were cultured and transfected with plasmid DNA (miR-625) and scrambled as the control using the Lonza electroporation system. Flow cytometry was used to evaluate cell cycle, proliferation, and apoptosis. Relative gene expression was validated by qRT-PCR. All data were analyzed using graph pad prism 7.01 and REST 2009.
Results: KG-1 cells transfected with the mir625-GFP construct showed decreased proliferation, increased apoptosis, and induced cell cycle arrest. Low levels of Sox2, p21, cyclin E, and up-regulation of p27 were confirmed and validated by qRT-PCR ( P < 0.05 ).
Conclusion: MiR-625 can be a promising approach to aid in the treatment of AML. However, further studies are required in this field
THE PSYCHOEDUCATION OF LANGUAGE DISORDERS IN EARLY CHILDHOOD FOR PARENTS AND TEACHERS AT ECC DEWI SARTIKA MOJOKERTO
Authors: Aisyati Wardah Wuri , Ika Ayuni Nurmaulidiya  , Raisya Aulia  , Waode Syaifatul Rohmadhani  , Nur Ainy Fardana  
Published: October 2024

Introduction: Based on an initial survey conducted among parents, prospective parents, and educators at ECC Dewi Sartika, Mojokerto, it was found that 19% of people did not know about language disorders in early childhood. In addition, 29.3% of respondents did not know about the impact and urgency of handling language disorders in children. A total of 36.2% of respondents did not know about the symptoms or indications of language disorders in children, and as many as 58.6% of respondents did not know about how to treat children with language disorders, especially in early childhood. The purpose of giving psychoeducation is increasing knowledge and attitude of those directly involved in the child's growth and development process, so they can find out an overview of the development of language and speech in children.
Methods: The psychoeducation program is in the form of an interactive talk show conducted online through one of the video conference platforms. The target participants consisted of 8 teachers, 30 parents or caregivers, and 10 other parties who are directly or indirectly involved in the care and guidance of early childhood. Participants were given a pretest and post test to measure their knowledge and attitude towards language disorders in early childhood. The results obtained will be analyzed using a t-test with the Jamovi version 2.2.5 application.
Results: The difference in the mean score is 16,842 (CI95 = [∞, 14,135]), the delivery of promotive interventions in the form of psychoeducation has a significant effect on increasing knowledge and attitudes towards language disorders in early childhood (t(48) = 10,495, p=<.001 , Cohen's d=1,702).
Conclusion: This psychoeducation program is able to increase participants' understanding and attitude towards of language disorders in early childhood.
Lethal Autonomous Weapon Systems and Automation Bias
Authors: Güneysu Gökhan 
Published: October 2024

Autonomy in weapon systems is already a genuine concern. States try to come up with their own definitions of these systems and pay utmost effort to impose their own understanding of these systems upon other states. For a fairly high number of states barring a total ban on such weapons would be the ideal solution; however, such states that are anxious about the increase in autonomy in war-making capabilities, as adopts a second-best scenario to contain risks created by the deployment of such systems. To this end, placing them under meaningful human control emerges as an important political and legal objective. The author believes that placing autonomous weapons under human supervision, despite its initial promise, will yield negative results. This is due to the fact that humans tend rather to be too willing to follow the solutions generated by autonomous systems. First observed in other industries of civilian nature like aviation or health, automation bias has the potential to negate most if not all of supervision measures expected to ensure proper implementation of international humanitarian law.
Clinical and Immunological Features in Limpet (Patella sp.) Allergy: A New Trigger of Food Anaphylaxis
Authors: Mederos-Luis Elena , Galán Tania , Martínez María José , González-Pérez Ruperto , Sánchez-Machín Inmaculada , Pineda Fernando , Poza-Guedes Paloma 
Published: October 2024

Seafood is a vital source of nutrients, and its consumption has grown globally. Shellfish is a major cause of food allergy and anaphylaxis worldwide, affecting an estimated 0.5-2.5% of the general population. Most basic and clinical research has traditionally focused on crustaceans, leaving the characteristics of mollusk allergy poorly understood. In the Canary Islands, limpets (sea gastropod) are commonly consumed as part of the local cuisine. While some cases of limpet allergy have been reported, there are no published studies featuring large series or detailed clinical analyses of this specific food allergy. A cohort of patients with sensitization to limpet were studied: 66 were monosensitized to limpets (group A), while 64 were also sensitized to other shellfish (group B). Limpet ingestion caused delayed and severe symptoms. In group A, only 11,5% of patients showed positive shellfish allergen detection, compared to 67,9% in group B. The presence of protein bands in the 25-40 and 50-200 kDa range in monosensitized patients distinguishes our study from another researchs. Our study presents the largest reported series of patients with limpet allergy to date. The aim is to analyze the clinical and immunological characteristics of a local sample of limpet-allergic patients, contributing to a better understanding of this emerging condition.
Enhancing Sustainability and Efficiency in Gas Dehydration: Smart Optimization of Molecular Sieve Unit Regeneration
Authors: Bakr M. Khaleel 
Published: October 2024

Abstract
The objective of this study is to optimize the regeneration criteria of Molecular Sieve Units (MSUs) to enhance sustainability and operational efficiency in gas dehydration processes.
The methodology involves revising the regeneration cycle of MSUs to align with current operational demands. By analyzing the underutilization of desiccant beds within the existing 12-hour adsorption cycle, a tailored regeneration cycle was implemented. This strategy focuses on reducing fuel gas consumption and electricity usage, while extending the operational lifetime of the desiccants. The process includes a detailed assessment of current operations and the development of an optimized regeneration schedule.
Implementing the revised regeneration cycle led to substantial improvements: an 85% reduction in fuel gas consumption and an 83% decrease in electricity usage. The desiccant's operational lifetime was extended from 5 years to 25 years, significantly reducing downtime and maintenance requirements. Additionally, the optimization resulted in notable reductions in spare parts usage and operational expenses (OPEX). The environmental benefits, including reductions in greenhouse gas (GHG) emissions, are currently being quantified. This approach demonstrates the potential for significant environmental and economic gains, highlighting the importance of tailored regeneration cycles in enhancing the efficiency and sustainability of gas dehydration processes.
This paper introduces a novel optimization strategy for MSU regeneration cycles, demonstrating significant improvements in resource utilization and operational efficiency. It provides valuable insights into extending the operational life of desiccants and reducing energy consumption, contributing to the sustainable management of industrial operations.