bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, practices, and perceptions of the healthcare providers on cervical cancer screening among HIV-positive women at Lira Regional Referral Hospital, Lira City.
Authors: Layet Florence , Murungi Tom , Ashaba Nasser , Nakayita Mirembe Renniter , Kigongo Eustes , Opollo Marc Sam 
Published: September 2024

Abstract

Background: Cervical cancer remains a global burden and is by far one of the major causes of premature death among women of reproductive age. We explored the knowledge, practices, and perceptions of healthcare providers on cervical cancer screening among HIV-positive women aged 18-49 years in Lira City.
Methods: In June 2023, a qualitative cross-sectional study was conducted among healthcare providers at Lira Regional Referral Hospital (LRRH), Lira City, Northern Uganda. Key informant interviews (KII’s) were used to collect data among purposively selected healthcare providers. Interviews were audio-recorded, transcribed verbatim and coded using the NVivo (QSR International) software. Thematic content analysis was used in data analysis.
Results: The study found that participants had good knowledge about cervical cancer and screening. They provided health education, and vaccination for eligible girls and screened HIV-positive women for cervical cancer. Long waiting hours, long distances to healthcare facilities, and negative attitudes of some health providers were reported as barriers to CCS utilization. However, increased awareness, the presence of signs/symptoms, and the desire to maintain optimal health facilitated CCS utilisation among HIV-positive women.
Conclusion: Healthcare providers knew about cervical cancer screening by HPV testing and Visual Inspection with Acetic acid and provided routine health education on screening, and cervical cancer screening to HIV-positive women. They perceived increased demand for CCS services by HIV-positive women, which is attributed to their increased awareness, the presence of signs and symptoms, and their desire to maintain optimal health. Despite several hindering factors, such as long waiting hours, long distances to healthcare facilities, and negative attitudes of some health providers, the practice of cervical cancer screening can be improved by reducing waiting times, increasing access to healthcare facilities, and ensuring that patients feel comfortable throughout the screening process.
An in-vivo Analysis of the Positional Relationship of Palatal Rugae with Maxillary Teeth in Different Arch Forms Among Young Dentulous Gujarati Individuals-A Pilot Study
Authors: Shah Rutu 
Published: September 2024

Background- The palatal rugae are transverse folds of tissue located in the anterior portion of the hard palate. They are considered to be reliable landmarks with manifold uses in the field of orthodontics and forensics. The current study was carried out with the aim of determining if a positional relationship of palatal rugae exists with the maxillary teeth in individuals with different maxillary arch forms.
Material and method- The study was carried out in 100 participitants (87 females and 13 males) . Irreversible hydrocolloid impressions were made and casts were poured in Type 3 dental stone. The casts were divided according to arch forms as taper, ovoid and square. Palatal rugae on the casts were assessed digitally and the position of the most posterior rugae evaluated in relation with the adjacent maxillary teeth.
Results –It was observed that the palatal rugae had a higly significant positional relationship with the maxillary posterior teeth(p value <0.0001) . In the ovoid and square arches, majority of the individuals had the most posterior rugae lying at the level of distal margin of 2nd premolar while in cases of taper dental arches, maximum number of individuals had the distal margin of 1st premolar coincide with the most posteriorly located rugae.
Conclusion- Hence, it can be concluded that the most posterior limit of the rugae may serve as a reliable guide for the arrangement of the maxillary teeth in different arch forms.
Key Words- Palatal Rugae, maxillary anterior teeth , denture aesthetics
Comparative Evaluation of Efficacy of Drynaria Herbal Mouthwash and Chlorhexidine Mouthwash on Gingivitis: A Randomized Controlled Trial.
Authors: Dr. Neelam Mittal  , Dr. Kaushal Pati Tripathi  , Dr. Anju Gautam  , Dr. Rashika M  
Published: September 2024

ABSTRACT:

Introduction: Herbal products are preferred widely to synthetic medications owing to their minimal adverse effects and cost effectiveness. Drynaria is a popular traditional medicine used for bone repair, inflammation, hyperlipidemia, arteriosclerosis, rheumatism, and osteoporosis. This study was aimed to evaluate the effectiveness of Drynaria mouthwash in reduction of gingival inflammation in comparison with commercially available chlorhexidine (CHX) mouthwash.

Materials and Methods: This parallel arm, randomized controlled clinical trial was carried out on 30 participants with mild to moderate gingivitis who were divided into two groups. Scaling and root planning were done. Group A patients were given Chlorhexidine mouthwash (CHX) and Group B patients were given Drynaria Herbal mouthwash for 21 days. The clinical parameters assessed were Bleeding on Probing (BOP), Plaque Index (PI), and Gingival Index (GI) at baseline, 2 weeks, 3 weeks, and 4 weeks post use of the mouthwash.

Result: Drynaria mouthwash provided results that were significantly effective in improving all the clinical parameters.

Conclusion: Based on the results of the study, Drynaria as a mouthwash is nearly effective as Chlorhexidine mouthwash for the treatment of gingivitis.

Key words: Chlorhexidine gluconate, Drynaria, Herbal, Mouthwash, Gingivitis.
Menstrual waste behaviour of young adolescents: a theory of planned behaviour approach
Authors: Sreekumar Sandhya , Pandey Anju 
Published: September 2024

ABSTRACT
There is a significant rise in the pile of non-biodegradable menstrual waste. Still, the majority of the studies focused on the variety and quality of menstrual products, and only a few investigated the sustainable and safe disposal of used menstrual material. The theory of planned behaviour serves as the foundation upon which the paper constructs its theoretical framework to study menstrual waste disposal behaviour among adolescents. It finds that a variety of social contexts and circumstances influence adolescents' intentions to dispose of used menstrual products carelessly, indirectly contributing to environmental degradation. This paper is an attempt to examine the existing gap in the literature and understand the attitudes and intentions that underlie such an activity. This paper also suggests ways for policymakers and implementors to influence the behaviour of adolescents resulting in hygienic and environmentally safe disposal of menstrual waste.
Mediatyzacja a propaganda oraz teksty kultury. Kilka uwag dyskusyjnych
Authors: Lichański Jakub Z. 
Published: September 2024

Problem, który wskazałem w tytule, nasuwa bardzo wiele wątpliwości już na etapie wstępnym, czyli gdy zastanawiamy się, jak zatytułować rozważania. Należy bowiem, co postaram się pokazać, określić takie kwestie jak: 1.propaganda i jej rozumienie; 2. czy media są, a jeśli tak, to czym ograniczone w swej swobodzie tworzenia i przekazywania informacji, wreszcie – 3.jak, zgodnie z teorią, winny być tworzone informacje. Wiązać to można i trzeba z zasadami jeszcze określonymi w latach siedemdziesiątych XX wieku. James Carey (1974, 227-249) wskazuje na następujące zasady:1. krytyka standardów odpowiedzialności publicznej lub społecznej; 2.krytyka naukowa; 3. krytyka kulturowa. Jak zauważa Carey (1974: 244): „Przez kulturę krytyki mam na myśli ciągły proces debaty między prasą / mediami a publicznością, a w szczególności z tą jej częścią, która – ze względu na motywy i umiejętności – najbardziej kwalifikuje się do wejścia na krytyczną arenę [możliwego sporu / oceny]”. Tu zatem pojawia się problem, z którym mamy do czynienia w dotychczasowym sposobie prowadzenia debaty medialnej na temat, który nas interesuje. Jest jednakże jeszcze jeden problem, a mianowicie sposób kształtowania samej informacji medialnej. W tym zakresie oprę się na rozważaniach Josepha Ratzingera (Ratzinger 1984, 82-84), który przedstawił podstawowe problemy związane z tą kwestią. Hipoteza, która będę starał się udowodnić, brzmi prosto: oto przekaz medialny, niezależnie od tego, kto go przedstawia, jest sposobem kształtowania obrazu rzeczywistości. Jednym ze zbiorów przykładów dowodzących tej hipotezy będzie, poza przykładami wziętymi z przekazów medialnych, będą teksty kultury, resp. wybrane teksty kultury popularnej.
Physical Activity Level, Weight Categories, and Fat Distribution: A Cross- Sectional Study of College Students
Authors: Hammoud Emne , Banu Shaik Balkhis , El Bawab Raghda Ibrahim , El-Sobkey Salwa B. 
Published: September 2024

Introduction:
Overweight and obesity are growing problems worldwide, along with a decrease in physical activity. This trend is also seen in the United Arab
Emirates, including insufficient exercise among university students. This study aimed to evaluate the physical activity level, weight categories, and
fat distribution among female college students and determine the correlations and associations between these factors and demographic factors.

Methods:
A cross-sectional quasi-experimental study was conducted among 204 female undergraduate health profession students recruited through a
convenience sampling technique. Data were collected using anthropometric measurements and a self-administered International Physical Activity
Questionnaire (IPAQ). The relationships between weight categories (Body Mass Index, BMI), fat distribution (Waist-to-Hip Ratio, WHR), and
levels of physical activity, as well as the relationship between BMI and WHR, were analyzed using the PSPP statistical program.

Results:
The mean age of the students was 20.5 ± 1.9 years, with an average BMI of 25.4 ± 6.6 kg/m2. About 60.3% of the students were moderately active.
Physical activity levels were significantly associated with BMI categories (P= 0.008). BMI and WHR categories were also significantly associated
(P= 0.012). There was a strong association between students' perceived physical activity levels and their actual activity, as measured by the IPAQ
short form (P= 0.001). No significant relationships were found between physical activity, anthropometrics, and demographic characteristics

Conclusion:
Female college students demonstrated moderate levels of physical activity, and a negative correlation was detected between their physical activity
levels and weight categories. None of the studied demographics showed a correlation or association.
Boroxazolidones: Synthesis, In Silico and In Vitro Evaluation as ACE/AChE Dual Inhibitors, and In Vivo Testing of Antihypertensive Activity
Authors: Alina Barquet-Nieto , José G. Trujillo-Ferrara , Erik Andrade-Jorge , Jessica E. Rodríguez- Rodríguez , Itzell A. Gallardo-Ortíz , Rafael Villalobos-Molina 
Published: September 2024

Background:
Systemic arterial hypertension is a serious chronic health
problem caused by multiple factors. It is a major risk factor for Cardiovascular Diseases
(CVDs), including heart failure, coronary heart disease, and myocardial infarction. Hypertension
can be effectively treated with inhibitors of the Angiotensin Converting Enzyme
(ACE), such as captopril, enalapril, and lisinopril. However, these drugs are associated
with significant adverse reactions (e.g., persistent coughing, skin rashes, and angioedema).

Objective:
Considering the recent insights obtained by our group into the antihypertensive
effect of boroxazolidones, the aim of the current contribution was to design and synthesize
a series of these compounds derived from α-amino acids and evaluate them (in
silico and in vitro) as inhibitors of ACE and acetylcholinesterase (AChE).

Methods:
The best candidates were examined for their in vivo antihypertensive activity
to regulate high blood pressure in male spontaneously hypertensive rats. Although
boron-containing compounds were once thought to be toxic in any medical context, they
have increasingly been used as antibiotics, antiseptics, and antineoplastic agents. BXZHis,
BXZ-Lys, BXZ-Orn, BXZ-Phe, and BXZ-Pro were selected in silico as promising
ACE and AChE inhibitors. After synthesis, these molecules were tested in vitro as ACE
and AChE inhibitors, finding that most were effective at micromolar concentrations.
The two best candidates, BXZ-Lys and BXZ-His, were evaluated in vivo with spontaneously
hypertensive rats.

Results:
BXZ-Lys significantly decreased systolic, diastolic, and mean blood pressure,
being more potent than a common ACE inhibitor, captopril.

Conclusion:
Future research is required to elucidate the mechanism of action of this antihypertensive
effect.
An Overview of the Analytical Methods for Products Based on Clindamycin and Eco-efficiency Perspectives
Authors: Lustosa Isadora Alves , Kogawa Ana Carolina 
Published: September 2024

Background:
Clindamycin (CLIN), an antibiotic sold in the form of capsules, injectable solution,
gel, and lotion, is easily soluble in water and ethanol. However, it lacks eco-efficient methods for evaluating
pharmaceutical products.

Objective and Method:
The objective of this review is to provide an overview of the analytical methods present
both in the literature and in official compendia for evaluating pharmaceutical matrices based on CLIN in
the context of Green Analytical Chemistry (GAC).

Results:
Firstly, microbiological methods for evaluating the potency of CLIN final products were not found,
which already shows the need to develop new methods. Among the methods found, which are all physicalchemical,
the most used method is HPLC (71%) followed by UV-Vis (14%). Among the targets of the methods,
capsules and raw materials were the most studied (33% each). Among the choices of analytical conditions
for the methods, acetonitrile is the preferred solvent (27.7%), even though CLIN is easily soluble in ethanol.

Conclusion:
Thus, the gap in eco-friendly and sustainable analytical methods is a reality and an opportunity
for analytical development centers to provide means for evaluating the quality of CLIN-based products.
Comprehensive Analysis of Tertiary Lymphoid Structures in Pancreatic Cancer: Molecular Characteristics and Prognostic Implications
Authors: Fang Jiana , Huang Jingru , Zhang Jiazhong , Chen Lin , Deng Jin 
Published: September 2024

Purpose:
The molecular properties of TLSs in pancreatic cancer are still not well comprehended.
This research delved into the molecular properties of intratumoral TLSs in pancreatic
cancer through the exploration of multi-omics data.

Methods:
Seven key genes were identified through Cox regression analysis and random survival
forest analysis from a total of 5908 genes related to TLSs. These genes were utilized to construct a
prognosis model, which was subsequently validated in two independent cohorts. Additionally, the
study investigated the molecular features of different populations of TLSs from multiple perspectives.
The model’ s forecasting accuracy was verified by analyzing nomogram and decision curves,
taking into account the patients’ clinical traits.

Results:
The analysis of immune cell infiltration showed a notably greater presence of Macrophage
M0 cells in the group at high risk than in the low-risk group. The pathway enrichment analysis
demonstrated the activation among common cancer-related pathways, including ECM receptor interaction,
pathways in cancer, and focal adhesion, in the high-risk group. Additionally, the methylation
study revealed notable disparities in DNA methylation between two TLS groups across four
regions: TSS200, 5’ UTR, 1stExon, and Body. A variety of notably distinct sites were linked with
PVT1. Furthermore, by constructing a competing endogenous RNA network, several mRNAs and
lncRNAs were identified that compete for the binding of hsa-mir-221.

Conclusion:
Overall, this research sheds light on the molecular properties of TLSs across various
pancreatic cancer stages and suggests possible focal points for the treatment of pancreatic cancer.
Structural Optimization of Quinazolin-4-one Derivatives as Novel SARS-CoV-2 Mpro Inhibitors by Molecular Simulation
Authors: Wu Jinping , Li Peng , Mu Yucheng , Peng Ruiguang , Zhao Zhongyao , Lei Jinke , Tu Aiping , Gao Zhiting , Bai Yixiao , Wu Gang 
Published: September 2024

Background:
Severe acute respiratory syndrome coronavirus 2 main protease (SARSCoV-
2 Mpro) has been shown to be an effective target for inhibiting novel coronaviruses, which can
be used as a crucial breakthrough for developing drugs to treat the coronavirus disease 2019
(COVID-19).

Methods:
To design novel SARS-CoV-2 Mpro inhibitors, we conducted 3D-QSAR, molecular docking,
and molecular dynamics (MD) simulation on 64 quinazolin-4-one derivatives.

Results:
Comparative molecular field analysis (CoMFA) model (q2 = 0.590, R2 = 0.962), comparative
molecular similarity index analysis (CoMSIA) model (q2 = 0.628, R2 = 0.923), and external validation
indicated that the stability, reliability, and prediction performance of our constructed model were excellent.
We designed 8 inhibitors with stronger antiviral activities through the three-dimensional equipotential
field. Molecular docking and MD simulation probed the interactions of compounds and SARS-CoV-
2 Mpro. This indicated that amino acid residues, including Met165, Met49, and Cys145, were very important
in combination with the compounds. The prediction results of ADME/T and Lipinski’s rule of
five indicated that the new compounds had favorable drug-like and pharmacokinetic properties

Conclusion:
This study provided new ideas for exploring novel SARS-CoV-2 Mpro inhibitors against
COVID-19 in the future.
Repurposing Drugs as Host-Directed Therapy in Tuberculosis
Authors: Xavier V Andrew Marie , Ravichandran Mirunalini 
Published: September 2024

Abstract:
Tuberculosis is a chronic infective respiratory disease that has been known to mankind
for centuries and is still responsible for higher rates of morbidity and mortality globally. Repurposing
drugs as host-directed therapies as an add-on drug to tuberculosis is a promising scope to
study as it may have a significant impact in reducing the treatment duration and complications of
tuberculosis. Host-directed therapy is a strategy to target the host and its immune mediators responsible
for pro and anti-inflammatory pathways, thus modifying them with drugs to achieve increased
bacterial clearance and reduced long-term inflammatory-mediated complications of tuberculosis.
Various drugs approved for other indications have been studied in preclinical animal and
in vitro studies, as well as clinical trials in tuberculosis. These drugs mainly aim to improve mycobacterial
clearance and minimize post-TB consequences by suppressing inflammatory mediators.
Drugs such as metformin, imatinib, vitamin D, and (Vascular Endothelial Growth Factors)
VEGF drugs are studied for their ability to modulate the anti-inflammatory effects, and drugs,
such as doxycycline, corticosteroids, and N-acetylcysteine are being studied for their role as proinflammatory
modulators. This repurposing drug helps in using these drugs as an adjuvant in tuberculosis,
for which the safety is already established through various clinical trials post-marketing
surveillance. However, the interaction of these drugs with the standard anti-tubercular drugs
and with the disease needs to be studied. In the near future, this host-directed therapy might unlock
various management approaches not only in tuberculosis but also in other infective diseases
as the action of drugs is on the host.
Characterization and Antimicrobial Activity of Postbiotic from Lactobacillus Acidophilus LA5 on Staphylococcus Aureus in Food Model and In vitro
Authors: Khani Nader , Abedi Soleimani Roya , Homayouni Rad Aziz 
Published: September 2024

Background:
Postbiotics, also called biogenics, metabiotics, or Cell-Free Supernatants
(CFS), are soluble compounds produced by live probiotic microorganisms or released after the lysis
of probiotics that could provide beneficial health effects to the host.

Objective:
This study was conducted with the aim of investigating the antimicrobial, antibiofilm,
antioxidant, and cytotoxic effects of postbiotics derived from Lactobacillus acidophilus.

Methods:
In this study, the antimicrobial properties of the postbiotic of L. acidophilus on Staphylococcus
aureus were investigated in different experimental settings, in-vitro, and pasteurized milk.
The antioxidant effect of postbiotic was also evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH)
and 2, 20-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method. Furthermore, the
chemical composition of the postbiotics was identified via gas chromatography-mass spectrometry.
The cytotoxic effects of the compounds were investigated using a human normal cell line.

Results and Discussion:
According to the results, postbiotics had aconcentration-dependent antimicrobial
effect, and the inhibitory effect increased with increasing concentrations. The antimicrobial
activity was mainly linked with lactic acid and laurostearic acid. The Minimum Inhibitory
Concentration (MIC) of the prepared postbiotic was determined to be 100 mg/ml. The lowest Minimum
Effective Concentration (MEC) of postbiotics significantly differed in the food matrix, and a
low MEC (minimum effective concentration) index (150 mg/ml) was detected for postbiotic of L.
acidophilus.

Conclusion:
Therefore, the prepared postbiotic should be subjected to more in-depth analysis to
examine its suitability as a food additive.
Recent Advances of the Ultimate Microbial Influenced Corrosion (MIC): A Review
Authors: Albarqouni Yasin , Sanad Gomaa , Chong Kwok Feng , Abu Bakar Nurul Huda , Althubaiti Randa , Abdullah Arman 
Published: September 2024

Abstract:
The persistent corrosion of metal surfaces poses a significant engineering challenge,
including material degradation, loss of metal-structural integrity, and massive maintenance costs
in various industrial, medical, and aerospace applications. Microorganisms such as archaea,
bacteria, fungi, and microalgae can directly or indirectly influence metal corrosion. The degree
of corrosiveness and corrosion healing varies depending on the microbe, medium, and metal
substrate characteristics. Several attempts have been made to reveal answers to all questions
about MIC. The published reports focused on testimonial failures and laboratory or field tests
under varied situations. This review offers an overview of the most recent MIC research and
emphasizes the scarcity of data on MIC detection, estimation, and the most recent approaches
for MIC management. The review extends previously reported works and summarizes efforts for
better understanding and cutting off MIC management in advanced technologies. Furthermore, it
concludes with a final discussion of the current and future drawbacks and protective systems for
preventing microbial-induced corrosion.