bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОСОБЛИВОСТІ СІЛЬСЬКОГОСПОДАРСЬКОЇ ДІЯЛЬНОСТІ В СУЧАСНИХ УМОВАХ ГОСПОДАРЮВАННЯ
Authors: Levandivskyi O.T. 
Published: December 2017

У статті досліджено підходи економістів до вивчення сільськогосподарської діяльності в сучасних умовах господарювання. У ґенезі цієї проблеми показано основні підходи. Наголошується, що сучасне ведення сільського господарства тісно пов'язане з інвестиційною діяльністю.
Обґрунтовуються зональні системи ведення агропромислового виробництва що базується на функціональних і організаційних підсистемах сільськогосподарського виробництва. При цьому функціональні підсистеми відображають безпосередньо зміст, як окремих стадій, так і в цілому самого процесу виробництва. У наукових дослідженнях найчастіше виділяють технологічну, екологічну, економічну і соціальну функціональні підсистеми, форма функціонування яких відображається в організаційних підсистемах.
Наголошується, що при організації і веденні сільськогосподарського виробництва, а також при розробці заходів з вдосконалення його організаційно-економічного механізму необхідно враховувати, особливості сільськогосподарської діяльності без яких неможливо досягти високого рівня ефективності виробництва.
The ModERN Resource: Genome-Wide Binding Profiles for Hundreds ofDrosophilaandCaenorhabditis elegansTranscription Factors
Authors: Kudron Michelle M , Victorsen Alec , Gevirtzman Louis , Hillier LaDeana W , Fisher William W , Vafeados Dionne , Kirkey Matt , Hammonds Ann S , Gersch Jeffery , Ammouri Haneen , Wall Martha L , Moran Jennifer , Steffen David , Szynkarek Matt , Seabrook-Sturgis Samantha , Jameel Nader , Kadaba Madhura , Patton Jaeda , Terrell Robert , Corson Mitch , Durham Timothy J , Park Soo , Samanta Swapna , Han Mei , Xu Jinrui , Yan Koon-Kiu , Celniker Susan E , White Kevin P , Ma Lijia , Gerstein Mark , Reinke Valerie , Waterston Robert H 
Published: December 2017

AbstractThe model organism Encylopedia of Regulatory Elements (modERN) project was designed to generate genome-wide binding profiles for the majority of transcription...To develop a catalog of regulatory sites in two major model organisms, Drosophila melanogaster and Caenorhabditis elegans, the modERN (model organism Encyclopedia of Regulatory Networks) consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecessor, modENCODE (Model Organism ENCyclopedia Of DNA Elements), we now have data for 262 TFs identifying 1.23 M sites in the fly genome and 217 TFs identifying 0.67 M sites in the worm genome. Because sites from different TFs are often overlapping and tightly clustered, they fall into 91,011 and 59,150 regions in the fly and worm, respectively, and these binding sites span as little as 8.7 and 5.8 Mb in the two organisms. Clusters with large numbers of sites (so-called high occupancy target, or HOT regions) predominantly associate with broadly expressed genes, whereas clusters containing sites from just a few factors are associated with genes expressed in tissue-specific patterns. All of the strains expressing GFP-tagged TFs are available at the stock centers, and the chromatin immunoprecipitation sequencing data are available through the ENCODE Data Coordinating Center and also through a simple interface (http://epic.gs.washington.edu/modERN/) that facilitates rapid accessibility of processed data sets. These data will facilitate a vast number of scientific inquiries into the function of individual TFs in key developmental, metabolic, and defense and homeostatic regulatory pathways, as well as provide a broader perspective on how individual TFs work together in local networks and globally across the life spans of these two key model organisms.
The Concept of Biosimilars: From Characterization to Evolution—A Narrative Review
Authors: Farhat Fadi , Torres Alfredo , Park Wungki , de Lima Lopes Gilberto , Mudad Raja , Ikpeazu Chukwuemeka , Abi Aad Simon 
Published: December 2017

Abstract

Biologic agents are currently the fastest emerging segment of drug expenditure. Unlike chemically synthesized small-molecule drugs, biologics are more complex, medicinal products produced by a living organism. They have become part of the standard of care in the treatment of a large variety of diseases, such as growth disorders, autoimmune diseases, cancer, cardiovascular illnesses, hemophilia, and rare genetic conditions, to name a few. Biosimilars, which are copies of biologics that are highly similar, were introduced in the market with an aim to offer efficacy that is not clinically different from the originator or reference product, at lower prices. We aim to clarify the concept of biosimilar, from definitions, history, market entry, challenges faced, and future evolution. For that purpose, we performed a literature search on the sites of the medicines regulatory agencies and PubMed from 1990 to 2014 with the keywords “biosimilars,” “market,” and “regulatory.” In 2006, the first biosimilar, somatropin [rDNA origin], was marketed and led the way for biosimilar drug manufacturing. As a result, manufacturers have entered a diversified competition, facing challenges in manufacturing these complex agents, such as immunogenicity and efficiency. Biosimilars are set to evolve differently in various markets, namely the U.S., Japan, the European Union, and the “pharmerging” economies.

Implications for Practice
This article highlights the importance of biosimilars, as a cost-cutting strategy, in the delivery of state-of-the-art health care in developing countries, at a fraction of what a reference biological agent would cost.
Refugees in Conflict: Creating a Bridge Between Traditional and Conventional Health Belief Models
Authors: Ben-Arye Eran , Bonucci Massimo , Daher Michel , Kebudi Rejin , Saad Bashar , Breitkreuz Thomas , Rassouli Maryam , Rossi Elio , Gafer Nahla , Nimri Omar , Hablas Mohamed , Kienle Gunver Sophia , Samuels Noah , Silbermann Michael 
Published: December 2017

Abstract

The recent wave of migration from Middle Eastern countries to Europe presents significant challenges to the European health profession. These include the inevitable communication gap created by differences in health care beliefs between European oncologists, health care practitioners, and refugee patients. This article presents the conclusions of a workshop attended by a group of clinicians and researchers affiliated with the Middle East Cancer Consortium, as well as four European-based health-related organizations. Workshop participants included leading clinicians and medical educators from the field of integrative medicine and supportive cancer care from Italy, Germany, Turkey, Israel, Palestine, Iran, Lebanon, Jordan, Egypt, and Sudan. The workshop illustrated the need for creating a dialogue between European health care professionals and the refugee population in order to overcome the communication barriers to create healing process. The affinity for complementary and traditional medicine (CTM) among many refugee populations was also addressed, directing participants to the mediating role that integrative medicine serves between CTM and conventional medicine health belief models. This is especially relevant to the use of herbal medicine among oncology patients, for whom an open and nonjudgmental (yet evidence-based) dialogue is of utmost importance. The workshop concluded with a recommendation for the creation of a comprehensive health care model, to include bio-psycho-social and cultural-spiritual elements, addressing both acute and chronic medical conditions. These models need to be codesigned by European and Middle Eastern clinicians and researchers, internalizing a culturally sensitive approach and ethical commitment to the refugee population, as well as indigenous groups originating from Middle Eastern and north African countries.

Implications for Practice
European oncologists face a communication gap with refugee patients who have recently immigrated from Middle Eastern and northern African countries, with their different health belief models and affinity for traditional and herbal medicine. A culturally sensitive approach to care will foster doctor-refugee communication, through the integration of evidence-based medicine within a nonjudgmental, bio-psycho-social-cultural-spiritual agenda, addressing patients' expectation within a supportive and palliative care context. Integrative physicians, who are conventional doctors trained in traditional/complementary medicine, can mediate between conventional and traditional/herbal paradigms of care, facilitating doctor-patient communication through education and by providing clinical consultations within conventional oncology centers.
As Gerações na EaD: Realidades que se conectam
Authors: Cofferri Fernanda Fátima , Martinez Marcia Lorena Saurin , Novello Tanise Paula 
Published: December 2017

A educação a distância envolve múltiplos sujeitos, cenários e experiências através das tecnologias digitais, promovendo um processo educativo que se modifica constantemente. Assim, este artigo tem como objetivo identificar quem são os estudantes matriculados, de 2007 a 2016, na modalidade a distância em cursos de graduação e pós-graduação da Universidade Federal do Rio Grande: FURG. Para tanto, realizou-se um levantamento no sistema da Universidade para ter acessos aos dados de matrícula que permitissem realizar o mapeamento. A análise foi balizada nos estudos do processo evolutivo entre as gerações Baby Boomers, X e Y na perspectiva de Oliveira (2009). Situar temporalmente quem são esses estudantes e quais são as gerações presentes na educação a distância torna-se fundamental, para refletir e elaborar estratégias pedagógicas que atendam os anseios e as especificidades do contexto atual da educação superior pública. Da mesma forma, problematizar o tema é como uma mola propulsora para que as instituições de educação superior (re)pensem a educação a distância como uma latente possibilidade de interações e construções neste processo educativo e coletivo. Palavras-chave: Educação a Distância, Estudantes, Gerações, Tecnologias Digitais. The Generations in EaD: Connected RealitiesAbstract Distance Education involves multiple subjects, scenarios, and experiences through digital technologies, promoting an educational process that is constantly changing. Thus, this article aims to identify who the enrolled students are, from 2007 to 2016, in distance mode in undergraduate and graduate courses of Universidade Federal do Rio Grande: FURG. To do so, a data collection of student registration in the University was conducted to allow the mapping. The analysis was based on studies of the evolutionary process between the Baby Boomers, X and Y generations from Oliveira (2009) perspective. To situate temporarily who these students are and which are the generations present in distance education, becomes fundamental to reflect and elaborate pedagogical strategies that meet the wishes and specificities of the current context of public higher education. Likewise, seeing that as a problem is a driving force for higher education institutions to (re) think distance education as a latent possibility of interactions and constructions in this educational and collective process.Keywords: Distance education, Students, Generations, Technologies.
Breast Cancer Awareness Among Zayed University Female Students
Authors: AlBlooshi Shaima K. , Al Kury Lina T. , Malindretos Pavlos 
Published: December 2017

Background/Aim: Breast cancer is one of the most common cancers among female population worldwide. In the United Arab Emirates, breast cancer accounts for 31-43% of all cancer types. Recently, breast cancer incidence has declined as a result of development of better diagnostic techniques. Good knowledge and awareness about early detection of signs and symptoms of the disease are the most important keys for reducing morbidity and mortality. This study aims to evaluate the level of awareness about the risk factors of breast cancer, as well as, the knowledge about screening methods among female students at Zayed University in Abu Dhabi. Method: A random cross-sectional survey was carried to evaluate the level of awareness about breast cancer among female students at Zayed University. A total of 100 females aged 18–31 from different colleges were included in the study. Data were analyzed using SPSS 21 program. Chi- square test was used together with Fisher’s exact test, as appropriate. P value <0.05 was considered significant. Results: The results show that there is a lack of knowledge and awareness about the risk factors for breast cancer. Only 12% of the participants knew that physical inactivity is a risk factor. However, 29% of the participants knew that obesity is a risk factor. Knowledge about screening methods was poor and varied according to the marital and educational status of the students. Only 17% of the total participants have done breast self-examination. Single women had less frequently performed breast self-examination compared to married women Although 40% of the participants knew about ultra sound, only 22% of the students did have the knowledge about the proper age of mammogram screening. Conclusion: The results point to the lack of awareness among female students about breast cancer, the risk factors and screening methods. Therefore, effective educational programs are required to improve the knowledge level of university students regarding breast cancer and related practices.
PRODUCTION OF HANDMADE PAPERS FROM SUGAR CANE BAGASSE AND BANANA FIBERS IN OMAN
Authors: Al-Sulaimani Khalsa , Dwivedi Priy Brat 
Published: December 2017

Solid waste is one of the biggest problem of civil society. In this project, agriculture waste from bagasse and banana fibers have been used to produce handmade paper. These fibers were collected, dried under the sun and passed through water vat to remove dust. Next, it is cooked with 10% caustic solution in pressure cooker and then blended in mixer for different timing. Diluted solution of Clorox was used for discoloration and purification of pulp.Three types of papers were made from ready pulp. First type was by made by using raw material only, second type by addition of 2% of CaCO3 and 2% of starch. And the third types by addition of 5% of both additives. These papers were dried and then ironed for straightening.GSM, pH, Thickness, Bulk, and Moisture Content were calculated for all types of papers. It was found that papers from bagasse fibers are heavy and suitable for heavy and rough usage. While paper from banana fibers are useful for soft usage like tissues, wipes, tracing paper etc. This project is ecofriendly as it used agricultural waste and only little electricity was used.
Simultaneous spectrophotometric determination of phenolic antioxidant (BHA and BHT) concentrations in pharmaceutical preparations and chewing gums using the H-point standard addition method
Authors: Özgür Mahmure , Kalaycioğlu Zeynep , Dülger Öznur 
Published: December 2017

A simple, rapid, and sensitive spectrophotometric method was developed for the simultaneous determination of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) concentration in pharmaceutical preparations and chewing gums, without prior separation steps, using the H-point standard addition method (HPSAM).The concentration of one antioxidant was calculated by overlapping spectra at two appropriately selected wavelengths at which the interferent, other antioxidant, should has the same absorbance value. Absorbances at two pairs of wavelengths, 265 and 288 nm (with BHA as analyte) or 288 and 293 nm (with BHT as analyte) were monitored, while adding standard solutions of BHA or BHT, respectively. Calibration graphs were determined at 4–20 μgml–1(r = 0.9981) for BHA and 20–100 μgml–1(r = 0.9940) for BHT in binary mixtures. The proposed method was tested and validated using various parameters according to ICH guidelines. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.48 and 1.51 μgml–1for BHA and 0.72 and 2.41 μgml–1for BHT, respectively. The percentage recovery ranges were 100.44–102.50 % for BHA and 96.45–100.04 % for BHT, with relative standard deviations (RSD) less than 1.48 % indicating reasonable repeatability of the method. The intra-day and inter-day precision tests showed reliable RSD values (< 2 %). The results obtained using HPSAM were statistically compared with results obtained using the derivative spectrophotometric method that was previously reported by us, showing high similarity between results.
Perbedaan Pola Pemberian Makan Batita Diasuh Ibu Dan Selain Ibu
Authors: Sari Putri Novita , Sumarmi Sri 
Published: December 2017

Background: In the present era, working women are increased, especially working mothers, therefore many children are not taken care by their parent. This situation may become risk factor for malnutrition among children in urban areas. Feeding pattern is indirect causes of nutritional problems in toddler. Objectives: The objective of the study was to analyze the difference of toddler feeding pattern and nutritional status between toddler who cared by mother and toddler who cared by other caregivers. Methods: The method of this research was observational with cross sectional design, and the sampling technique used simple random sampling. The number of samples were 74 toddlers. Variables observed in this study were socio-economic status of family, characteristics of caregivers and feeding pattern. The research was conducted in Mulyorejo urban village Surabaya. The data were analyzed by Chi-square test with α= 0.05. Results: The result of the research showed that there was no difference of feeding pattern (p=1.000) between toddler who cared by mother and toddler who cared by other caregivers. Conclusion: The conclusion from this research is in urban areas, feeding pattern is not only influenced by caregiver but also several factors such as economic status.ABSTRAK Latar Belakang: Di era sekarang, wanita semakin banyak bekerja khususnya ibu, sehingga semakin banyak anak yang tidak diasuh sendiri oleh orang tuanya. Situasi ini menjadi faktor resiko terjadinya masalah gizi pada anak di daerah perkotaan. Pola pemberian makan pengasuh yang tidak tepat pada batita termasuk faktor penyebab tidak langsung terjadinya masalah gizi pada batita.Tujuan: Tujuan penelitian untuk menganalisis perbedaan pola pemberian makan batita yang diasuh ibu dan batita yang diasuh selain ibu.Metode: Metode penelitian ini adalah observasional dengan desain cross sectional, dan teknik pengambilan sampel menggunakan simple random sampling. Jumlah sampel penelitian adalah 74 responden. Variabel yang diukur yaitu sosial ekonomi keluarga, karakteristik pengasuh dan pola pemberian makan. Penelitian dilakukan di Kelurahan Mulyorejo, wilayah kerja Puskesmas Mulyorejo Surabaya. Analisis data menggunakan uji statistik Chi-square dengan nilai α= 0,05.Hasil: Hasil penelitian menunjukkan tidak ada perbedaan pola pemberian makan antara batita diasuh ibu dan batita diasuh selain ibu dengan nilai p= 1,000 > 0,05.Kesimpulan: Simpulan dari hasil yaitu di daerah perkotaan, pola pemberian makan tidak hanya dipengaruhi oleh pengasuh batita tetapi beberapa faktor seperti status ekonomi keluarga.
Hubungan Usia Gestasi dan Kadar Hemoglobin Trimester 3 Kehamilan dengan Berat Lahir Bayi
Authors: Fanni Denna Rahinda Yulia , Adriani Merryana 
Published: December 2017

Background: The incidence of LBW is one of the health issues in Indonesia that still needs to be handled properly. This can be happen because of several factors which are gestational age and the 3rd trimester Hb level of pregnancy that the mother had during pregnancy. LBW may cause some health issues for infants such as infectious diseases, respiratory disorders, and central nervous system disorders. Objectives: This research has purpose to analyze relationship between gestational age and 3rd trimester Hb level of pregnancy with infant birth weight in working area of Tambak Wedi Surabaya Community Health Center. Method: This study used cross sectional design with 60 respondents as sample of research where chosen by simple random sampling system. The instruments that used were mother and baby characteristic questionnaire sheets and FFQ sheets for interviewing pregnancy consumption patterns. Data analysed using chi square statistic test. Results: There was a relationship between gestational age (p-value = 0.002) and 3rd trimester hemoglobin levels of pregnancy (p-value = 0.044) with infant birth weight. Conclusion: The variable of gestational age and the 3rd trimester Hb level of pregnancy has a relationship with the birth weight of infants in the working area of Tambak Wedi Surabaya Community Health Center. Gestational age which isn’t considered risky to give birth to LBW infants are gestational age >38 weeks while the 3rd trimester Hb level of pregnancy that isn’t classified risky to give birth to LBW baby is >11g / dl.ABSTRAK Latabelakang: Kejadian BBLR merupakan salah satu permasalahan kesehatan di Indonesia yang masih harus ditangani dengan baik. Hal ini dapat terjadi karena beberapa faktor salah satunya adalah usia gestasi dan kadar Hb trimester 3 kehamilan yang dimiliki ibu saat kehamilan. BBLR dapat menimbulkan beberapa masalah kesehatan pada bayi seperti penyakit infeksi, gangguan pernafasan, dan gangguan sistem saraf pusat.Tujuan: Penelitian ini memiliki tujuan untuk menganalisis hubungan usia gestasi dan kadar Hb trimester 3 kehamilan dengan berat lahir bayi di wilayah kerja Puskesmas Tambak Wedi Surabaya. Metode: Penelitian ini menggunakan desain cross sectional dengan besar sampel sebanyak 60 responden dimana dipilih dengan sistem simple random sampling. Instrumen yang digunakan adalah lembar kuisioner karakteristik ibu dan bayi serta lembar FFQ untuk wawancara pola konsumsi kehamilan. Analisis data menggunakan uji statistik chi square.Hasil: Terdapat hubungan antara usia gestasi (p-value = 0,002) dan kadar hemoglobin trimester 3 kehamilan (p-value = 0,044) dengan berat lahir bayi.Kesimpulan: Variabel usia gestasi dan kadar Hb trimester 3 kehamilan memiliki hubungan dengan berat lahir bayi di wilayah kerja Puskesmas Tambak Wedi Surabaya.Usia gestasi yang tergolong tidak berisiko untuk melahirkan bayi BBLR adalah usia gestasi >38 minggu sedangkan kadar Hb trimester 3 kehamilan yang tergolong tidak berisiko untuk melahirkan bayi BBLR adalah > 11g/dl.
HYPERBILIRUBINEMIA TREATMENT OF NEONATUS IN DR. SOETOMO HOSPITAL SURABAYA
Authors: Hosea Mellisa Kristanti , Etika Risa , Lestari Pudji 
Published: December 2017

Hyperbilirubinemia is a condition of high levels bilirubin accumulating in blood and known as jaundice, a yellow coloration of the skin, sclera and nails. Hyperbilirubinemia is a problem that often occurs in newborns. Patients with neonatal hyperbilirubinemia are treated with phototerapy and exchange transfusion. The purpose of this study was to identify the hyperbilirubinemia treatments on neonatal in Dr. Soetomo Hospital Surabaya. Medical records were used to collect information on hyperbilirubinemia status and type of treatments in 2010. Inclusion criteria were used to select samples in this study. All hyperbilirubinemia patients (100 neonates) were treated with phototherapy, in which 32% of them got the treatment for less than 24 hours; and 68% got the treatment more than 24 hours. After treatment, 100% patients cured. Hyperbilirubinemia neonates in RSUD Dr Sutomo were treated with phototherapy and the treatment was successful.