bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative wellbore integrity evaluation across a complex of oil and gas fields within the Michigan Basin and implications for CO2storage
Authors: Haagsma Autumn , Weber Stephanie , Moody Mark , Sminchak Joel , Gerst Jacqueline , Gupta Neeraj 
Published: August 2016

AbstractWellbore integrity is a fundamental aspect of site characterization and selection for storage in areas with existing or abandoned oil and gas wells. The condition of well cement, installed casing strings, and plugs determine if a well can sustain optimal hydrostatic pressures and prevent fluid migration. This is a necessary but underappreciated aspect of assessing potential storage sites when optimal and sustainable pressure conditions are critical for success. To apply the systematic wellbore integrity evaluation to realistic CO2storage conditions, seven fields in the Michigan Basin were selected which were actively being used for CO2injection for enhanced oil recovery. Data on wellbore construction were collected for wells on and surrounding the reefs and were evaluated to determine the overall condition of boreholes in the study area using EPA guidelines and industry standards. Available cement bond logs were also reviewed to assess the quantity and quality of cement in the wells. The majority of the wells in the study area were shallow and did not penetrate the confining layers, thus, posing little to no risk. Most of the deep wells demonstrated sufficient plugs and cement quality that meet the desired standards. Some wells have missing or incomplete records and inadequate cement and/or plugs making them candidates for further evaluation, should large‐scale CO2storage be considered in the area. The results of the study show that readily available well records and cement bond logs can be used to efficiently evaluate and characterize CO2storage study sites for overall wellbore integrity. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd.
Three New Abietane‐type Diterpenes from the Bark of Cryptomeria japonica
Authors: Chang Chi‐I , Chen Chien‐Chih , Wang Sheng‐Yang , Chao Che‐Yi , Chao Louis Kuoping , Chen Jih‐Jung , Ko Horng‐Huey , Chen Cheng‐Chi , Kuo Yueh‐Hsiung 
Published: August 2016

Three new abietane‐type diterpenoids, 7β‐acetoxy‐12‐methoxyabieta‐8,11,13‐triene‐6α,11‐diol (1), 7α‐acetoxy‐12‐methoxyabieta‐8,11,13‐triene‐6α,11‐diol (2), and 6α‐acetoxy‐12‐methoxyabieta‐8,11,13‐triene‐7α,11‐diol (3), as well as two known abietane‐type diterpenoids, 12‐methoxyabieta‐8,11,13‐triene‐6α,7β,11‐triol (4) and 6α‐acetoxy‐12‐methoxyabieta‐8,11,13‐triene‐7β,11‐diol (5), were isolated from the MeOH extract of the bark of Cryptomeria japonica. Their structures were determined by analysis of spectroscopic data and comparison of NMR data with those of related metabolites.
Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway
Authors: Amanullah Ayeman , Upadhyay Arun , Chhangani Deepak , Joshi Vibhuti , Mishra Ribhav , Yamanaka Koji , Mishra Amit 
Published: August 2016

ABSTRACTDiclofenac is the most commonly used phenylacetic acid derivative non‐steroidal anti‐inflammatory drug (NSAID) that demonstrates significant analgesic, antipyretic, and anti‐inflammatory effects. Several epidemiological studies have demonstrated anti‐proliferative activity of NSAIDs and examined their apoptotic induction effects in different cancer cell lines. However, the precise molecular mechanisms by which these pharmacological agents induce apoptosis and exert anti‐carcinogenic properties are not well known. Here, we have observed that diclofenac treatment induces proteasome malfunction and promotes accumulation of different critical proteasome substrates, including few pro‐apoptotic proteins in cells. Exposure of diclofenac consequently elevates aggregation of various ubiquitylated misfolded proteins. Finally, we have shown that diclofenac treatment promotes apoptosis in cells, which could be because of mitochondrial membrane depolarization and cytochrome c release into cytosol. This study suggests possible beneficial insights of NSAIDs‐induced apoptosis that may improve our existing knowledge in anti‐proliferative interspecific strategies development. J. Cell. Biochem. 118: 1014–1027, 2017. © 2016 Wiley Periodicals, Inc.
Synthesis and tribological behaviour of oleic acid‐capped lanthanum borate/graphene oxide nanocomposites
Authors: Li Wei , Cheng Zhi‐Lin , Liu Zan 
Published: August 2016

AbstractThe lanthanum borate/graphene oxide (LB/GO) nanocomposites were obtained by GO decorated by LB using an eco‐friendly hydrothermal method. For improving the oil solubility of the LB/GO nanocomposites, the oleic acid (OA)‐capped LB/GO (OA–LB/GO) nanocomposites were achieved. The as‐prepared nanocomposites were determined by a series of characterisations such as Fourier transform‐infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD), Raman, UV‐vis, transmission electron microscopy (TEM) and SEM. The results indicated that most of LB nanoparticles with the size of 50–100 nm were well loaded on the surface of GO nanosheets. In addition, the tribological properties of the as‐prepared nanocomposites were tested by a four‐ball friction machine. The results demonstrated that the OA–LB/GO nanocomposites were of good anti‐wear ability and excellent load‐carrying capacity. Copyright © 2016 John Wiley & Sons, Ltd.
Infimal convolution of total generalized variation functionals for dynamic MRI
Authors: Schloegl Matthias , Holler Martin , Schwarzl Andreas , Bredies Kristian , Stollberger Rudolf 
Published: August 2016

PurposeTo accelerate dynamic MR applications using infimal convolution of total generalized variation functionals (ICTGV) as spatio‐temporal regularization for image reconstruction.Theory and MethodsICTGV comprises a new image prior tailored to dynamic data that achieves regularization via optimal local balancing between spatial and temporal regularity. Here it is applied for the first time to the reconstruction of dynamic MRI data. CINE and perfusion scans were investigated to study the influence of time dependent morphology and temporal contrast changes. ICTGV regularized reconstruction from subsampled MR data is formulated as a convex optimization problem. Global solutions are obtained by employing a duality based non‐smooth optimization algorithm.ResultsThe reconstruction error remains on a low level with acceleration factors up to 16 for both CINE and dynamic contrast‐enhanced MRI data. The GPU implementation of the algorithm suites clinical demands by reducing reconstruction times of one dataset to less than 4 min.ConclusionICTGV based dynamic magnetic resonance imaging reconstruction allows for vast undersampling and therefore enables for very high spatial and temporal resolutions, spatial coverage and reduced scan time. With the proposed distinction of model and regularization parameters it offers a new and robust method of flexible decomposition into components with different degrees of temporal regularity. Magn Reson Med 78:142–155, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Prenatal exposure to antidepressants and risk of epilepsy in childhood
Authors: Mao Yanyan , Pedersen Lars Henning , Christensen Jakob , Vestergaard Mogens , Zhou Weijin , Olsen Jørn , Sun Yuelian 
Published: August 2016

AbstractPurposeThis study aimed to estimate the association between prenatal exposure to antidepressants and risk of epilepsy in childhood, taking maternal depression into account.MethodsWe conducted a population‐based cohort study including all Danish singletons born alive between 1997 and 2008 (n = 734 237). Information on antidepressant medication and diagnosis of depression and epilepsy was obtained from Danish National Registers. The exposed group comprised children of mothers who used antidepressants from 30 days before pregnancy until the date of birth. The reference group comprised children of mothers who used no antidepressants from 6 months before pregnancy to birth. We estimated the hazard ratios (HR) of epilepsy and 95% confidence intervals (CI) using Cox proportional hazard models.ResultsWe identified 12 438 (1.7%) children exposed to antidepressants during pregnancy (including 30 days before pregnancy) and 5829 (0.8%) children diagnosed with epilepsy in the follow‐up time (mean: 6.7 years). Children exposed to antidepressants during pregnancy had a 27% higher risk of epilepsy (aHR: 1.27; 95%CI: 1.05–1.54) than children in the reference group. The estimate of this association was 1.71 (95%CI: 1.10–2.66) if their mothers also had a registry‐based hospital diagnosis of depression in the 6 months before pregnancy or during pregnancy and 1.14 (95%CI: 0.91–1.43) if their mothers had no registry‐based hospital diagnosis of depression. Children of mothers who used antidepressants from 2 to 6 months before pregnancy (but not during pregnancy) had an increased risk of epilepsy (aHR: 1.36; 95%CI: 1.07–1.73).ConclusionsAntidepressant use during pregnancy was associated with a higher risk of epilepsy among children whose mothers had also a registry‐based hospital diagnosis of depression during pregnancy. Copyright © 2016 John Wiley & Sons, Ltd.
Characterization of low affinity Fcγ receptor biotinylation under controlled reaction conditions by mass spectrometry and ligand binding analysis
Authors: Geuijen Karin P.M. , Egging David F. , Bartels Stefanie , Schouten Jan , Schasfoort Richard B. , Eppink Michel H. 
Published: August 2016

AbstractChemical protein biotinylation and streptavidin or anti‐biotin‐based capture is regularly used for proteins as a more controlled alternative to direct coupling of the protein on a biosensor surface. On biotinylation an interaction site of interest may be blocked by the biotin groups, diminishing apparent activity of the protein. Minimal biotinylation can circumvent the loss of apparent activity, but still a binding site of interest can be blocked when labeling an amino acid involved in the binding. Here, we describe reaction condition optimization studies for minimal labeling. We have chosen low affinity Fcγ receptors as model compounds as these proteins contain many lysines in their active binding site and as such provide an interesting system for a minimal labeling approach. We were able to identify the most critical parameters (protein:biotin ratio and incubation pH) for a minimal labeling approach in which the proteins of choice remain most active toward analyte binding. Localization of biotinylation by mass spectrometric peptide mapping on minimally labeled material was correlated to protein activity in binding assays. We show that only aiming at minimal labeling is not sufficient to maintain an active protein. Careful fine‐tuning of critical parameters is important to reduce biotinylation in a protein binding site.
Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
Authors: Roy Sourav , Karmakar Tarak , Nagappa Lakshmeesha K. , Prahlada Rao Vasudeva S. , Balasubramanian Sundaram , Balaram Hemalatha 
Published: August 2016

ABSTRACTHypoxanthine‐guanine‐xanthine phosphoribosyltransference (HGXPRT), a key enzyme in the purine salvage pathway of the malarial parasite, Plasmodium falciparum (Pf), catalyses the conversion of hypoxanthine, guanine, and xanthine to their corresponding mononucleotides; IMP, GMP, and XMP, respectively. Out of the five active site loops (I, II, III, III', and IV) in PfHGXPRT, loop III' facilitates the closure of the hood over the core domain which is the penultimate step during enzymatic catalysis. PfHGXPRT mutants were constructed wherein Trp 181 in loop III' was substituted with Ser, Thr, Tyr, and Phe. The mutants (W181S, W181Y and W181F), when examined for xanthine phosphoribosylation activity, showed an increase in Km for PRPP by 2.1‐3.4 fold under unactivated condition and a decrease in catalytic efficiency by more than 5‐fold under activated condition as compared to that of the wild‐type enzyme. The W181T mutant showed 10‐fold reduced xanthine phosphoribosylation activity. Furthermore, molecular dynamics simulations of WT and in silico W181S/Y/F/T PfHGXPRT mutants bound to IMP.PPi.Mg2+ have been carried out to address the effect of the mutation of W181 on the overall dynamics of the systems and identify local changes in loop III'. Dynamic cross‐correlation analyses show a communication between loop III' and the substrate binding site. Differential cross‐correlation maps indicate altered communication among different regions in the mutants. Changes in the local contacts and hydrogen bonding between residue 181 with the nearby residues cause altered substrate affinity and catalytic efficiency of the mutant enzymes. Proteins 2016; 84:1658–1669. © 2016 Wiley Periodicals, Inc.
Analysis of proton wires in the enzyme active site suggests a mechanism of c‐di‐GMP hydrolysis by the EAL domain phosphodiesterases
Authors: Grigorenko Bella L. , Knyazeva Marina A , Nemukhin Alexander V. 
Published: August 2016

ABSTRACTWe report for the first time a hydrolysis mechanism of the cyclic dimeric guanosine monophosphate (c‐di‐GMP) by the EAL domain phosphodiesterases as revealed by molecular simulations. A model system for the enzyme‐substrate complex was prepared on the base of the crystal structure of the EAL domain from the BlrP1 protein complexed with c‐di‐GMP. The nucleophilic hydroxide generated from the bridging water molecule appeared in a favorable position for attack on the phosphorus atom of c‐di‐GMP. The most difficult task was to find a pathway for a proton transfer to the O3' atom of c‐di‐GMP to promote the O3'P bond cleavage. We show that the hydrogen bond network extended over the chain of water molecules in the enzyme active site and the Glu359 and Asp303 side chains provides the relevant proton wires. The suggested mechanism is consistent with the structural, mutagenesis, and kinetic experimental studies on the EAL domain phosphodiesterases. Proteins 2016; 84:1670–1680. © 2016 Wiley Periodicals, Inc.
Entwurfs‐ und Ausführungsplanung der Vinckekanalbrücke in Duisburg
Authors: Herbort Johannes , Schubart Ralf 
Published: August 2016

AbstractDer Oberbürgermeister‐Lehr‐Brückenzug in Duisburg verbindet die Stadtteile Ruhrort und Kaßlerfeld. Er überführt die Ruhrorter Straße über mehrere künstliche Wasserstraßen, eine innerörtliche Erschließungsstraße und die Ruhr. Als eine der wenigen Ruhrquerungen besitzt die Verkehrsverbindung eine übergeordnete Erschließungsfunktion für die Stadt Duisburg, insbesondere für den Wirtschaftsstandort rund um den Duisburger Hafen. Um der zunehmenden Verkehrsbelastung gerecht zu werden, müssen die bestehenden Verkehrsflächen des Brückenzuges ausgebaut werden, für den Straßenbahnverkehr ist ein besonderer Bahnkörper vorgesehen. Da eine Erweiterung und Grundinstandsetzung der vorhandenen Brückenbauwerke aufgrund ihrer Bauweise und des baulichen Zustandes auszuschließen ist, sind alle Bauwerke neu zu errichten. Die Gesamtmaßnahme zur Erneuerung des OB‐Lehr‐Brückenzuges teilt sich in zwei Bauabschnitte auf, der erste Bauabschnitt ist 2015 abgeschlossen worden, die Planungen für den zweiten haben 2011 begonnen. Der vorliegende Aufsatz erläutert die wesentlichen Aspekte der Entwurfs‐ und Ausführungsplanung für den Neubau der Vinckekanalbrücke im ersten Bauabschnitt.Preliminary und detailed design for the bridge construction crossing the Vincke‐Canal in Duisburg. The ”Oberbürgermeister‐Lehr” bridge construction in Duisburg connects the urban districts Ruhrort and Kaßlerfeld. With this bridge, the street Ruhrorter Straße crosses over several artificial waterways, a local access road and the river Ruhr. As one of the few Ruhr crossings, the connection holds a primary function for the city traffic of Duisburg, particularly for the industrial location around the harbor. In order to satisfy the increasing traffic load, the existing traffic areas of the bridge construction need to be expanded. The tram traffic will be separated with a dedicated track bed. Because of its structure and its state of repair, expansion and renewal of the existing bridge construction is not an option. Therefore all bridges will be rebuilt. The overall project of the renewal of the Oberbürgermeister‐Lehr bridge construction is divided into two construction phases. The first construction phase was finalized in 2015. The second phase started with the planning in 2011. The report at hand illustrates the most significant aspects of the preliminary and detailed design of the new construction for the Vincke‐Canal bridge in the first construction phase.
Linear edge effects on liana and tree communities in two tropical forest ecosystems in Ghana
Authors: Addo‐Fordjour Patrick , Owusu‐Boadi Kwame 
Published: August 2016

AbstractThe study determined linear edge effects on liana and tree community assemblages in moist semi‐deciduous (Afram Headwaters Forest Reserve) and upland evergreen (Tano Offin Forest Reserve) forests in Ghana. Fifteen plots (20 × 20 m2) were randomly set up at each habitat in the forests: edge habitat (0–40 m) and interior habitat (≥500 m). Lianas (diameter at 1.30 m from rooting base ≥1 cm) and trees (diameter at breast height, dbh ≥5 cm) were identified and enumerated in the plots. In the forest ecosystems, liana and tree species composition differed significantly between the two habitats. Liana and tree diversity did not differ significantly between edge and interior habitats. Nevertheless, edge habitat in moist semi‐deciduous forest supported significantly higher liana abundance and basal area than its interior habitat, whereas edge habitat in upland evergreen forest harboured significantly lower liana basal area than its corresponding interior habitat. Edge habitat in moist semi‐deciduous and upland evergreen forests had significantly lower tree abundance and basal area, respectively, than interior habitat. The results suggest that overall, linear edge effects on liana and tree assemblages were more pronounced in moist semi‐deciduous forest than upland evergreen forest. Lianas exhibited dominance over trees in edge habitat within moist semi‐deciduous forest, implying that they can have serious implications on tree diversity and ecosystem functioning in the forest. As our study is the first of its kind in the tropics with respect to edge type and forest ecosystems studied, our findings can contribute towards edge theory development.
Dance, “Stereotypes,” and Gender Relations: The Case of Lowland and Mountain Communities of Karditsa (Thessaly)
Authors: Dimopoulos Konstantinos , Tyrovola Vassiliki 
Published: August 2016

Gender identity is the main topic within the field of anthropology of gender: it is an identity with a polysemic character. The present paper focuses on the identity of social gender, since gender is a field of negotiation and a criterion for the analysis of culture. Social gender is a result of social-cultural constructions, established through the repetition of stereotypical dance acts. In this context, dance functions as a symbol, and its study allows the understanding of social structures, and therefore, the understanding of gender identity. Every dance event can be approached as a conceptual field, in which participants act according to gender standards and experience themselves as gender subjects.The aim of this paper is to show the gender social structures and relations within dance and dance practices, as they are imprinted on the mountain and lowland areas of Karditsa (Thessaly), in combination with the predominant social structures. For this purpose, we made use of the theoretical model of Hanna, where dance and dance executions are fields of negotiation of gender identity, as well as Cowan’ s model, according to which social gender can be studied within the context of “dance events.”Through the analysis of these “events,” several discrepancies in social structures and relations were detected between the lowland and mountain communities. These differences are based on dance occasions, and participation or lack of participation of both genders in these occasions, according to dance norms, dance order, and dance types. The above discrepancies constitute gender diversity among lowland and mountain communities, as a result of local social structures and the performative acts.
She's Beauty and She's Grace(less): The Mercurial Femininity of the Modern Disney Princess
Authors: Johnson Michelle 
Published: August 2016

Focusing on characters from Disney's three most recent “princess” films, Tangled (2010), Brave (2012), and Frozen (2013), I examine the development and divergence of these figures from “classic” Walt Disney models. Their mercurial character, as illustrated through gesture and movement, presents a firm contrast with and significant departure from their predecessors in films such as Cinderella (1950) and Sleeping Beauty (1959)—protagonists who exhibited a static character reflective of their social roles through the “embodiment” of balletic grace. Expanding on existing research comparing Walt Disney–era princesses with those from the Disney Renaissance of the 1980s and 1990s, I explore the significance of this shift in representation. Viewed as a metaphor for contemporary femininity, how do these modern princesses resolve the incongruity between their official social stations, proscribed behavior, and “real” personalities through their bodies over the course of the films?I believe that the conflict staged on these animated bodies is representative of larger societal issues emerging from contested definitions of both feminism and femininity, and that the Disney princess offers a contemporary site for the expression and resolution of this dissonance. Viewing the body of the Disney princess as representative of a larger female “social body” and conflict that occurs within her as indicative of the larger forces that shape female identity, I integrate my study with historical dance scholarship which regarded movement as indicative of the presence of an Apollonian/Dionysian dialectic working within culture.
Modularity lifting results in parallel weight one and applications to the Artin conjecture: the tamely ramified case
Authors: KASSAEI PAYMAN L. , SASAKI SHU , TIAN YICHAO 
Published: August 2016

AbstractWe extend the modularity lifting result of P. Kassaei (‘Modularity lifting in parallel weight one’,J. Amer. Math. Soc.26 (1) (2013), 199–225) to allow Galois representations with some ramification at $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}p$. We also prove modularity mod 5 of certain Galois representations. We use these results to prove new cases of the strong Artin conjecture over totally real fields in which 5 is unramified. As an ingredient of the proof, we provide a general result on the automatic analytic continuation of overconvergent $p$-adic Hilbert modular forms of finite slope which substantially generalizes a similar result in P. Kassaei (‘Modularity lifting in parallel weight one’, J. Amer. Math. Soc.26 (1) (2013), 199–225).