bluuebunny/crossref_metadata_2025_split huggingface dataset:
68Ga‐Ca‐phytate particles: A potential lung perfusion agent of synthetic origin prepared in a cold kit format
Authors: Hsieh William , Ali Masood , Praehofer Renee , Tsopelas Chris 
Published: September 2016

The objective of this study was to investigate the radiosynthesis of 68Ga‐Ca‐phytate particles and then characterize the formulation for radiochemical purity, radioactive particle size distribution, and biodistribution in normal rats. This radiotracer was prepared using a commercial phytate cold kit after reconstitution with saline, 68Ga‐chloride generator eluent, calcium chloride, and air, then heating at 100°C for 30 minutes to achieve 99% radiochemical purity of 68Ga‐particles that were 21% 3–5 μm, 8% 5–15 μm, and 71% >15 μm in diameter. This optimal formulation was stable for 2 hours at room temperature. Intravenous administration of 68Ga‐particles in rats resulted in an uptake of 93% in the lungs, 4% in the liver plus spleen, and 3% in the carcass after 20 minutes. Two‐thirds of the carcass activity was radioactive blood, likely to be 68Ga‐transferrin. The positron emission tomography image was superior than the 99mTc‐MAA image because it displayed high lung uptake against a low background. Low uptake by the liver, spleen did not interfere with the diagnostic quality, and faint activity in the submandibular (salivary) glands was due to 68Ga‐transferrin. The preclinical data so far indicate that 68Ga‐Ca‐phytate particles have good potential as a lung perfusion imaging agent.
Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis
Authors: June Ronald K. , Liu‐Bryan Ru , Long Fanxing , Griffin Timothy M. 
Published: September 2016

ABSTRACTObesity and associated metabolic diseases collectively referred to as the metabolic syndrome increase the risk of skeletal and synovial joint diseases, including osteoarthritis (OA). The relationship between obesity and musculoskeletal diseases is complex, involving biomechanical, dietary, genetic, inflammatory, and metabolic factors. Recent findings illustrate how changes in cellular metabolism and metabolic signaling pathways alter skeletal development, remodeling, and homeostasis, especially in response to biomechanical and inflammatory stressors. Consequently, a better understanding of the energy metabolism of diarthrodial joint cells and tissues, including bone, cartilage, and synovium, may lead to new strategies to treat or prevent synovial joint diseases such as OA. This rationale was the basis of a workshop presented at the 2016 Annual ORS Meeting in Orlando, FL on the emerging role of metabolic signaling in synovial joint remodeling and OA. The topics we covered included (i) the relationship between metabolic syndrome and OA in clinical and pre‐clinical studies; (ii) the effect of biomechanical loading on chondrocyte metabolism; (iii) the effect of Wnt signaling on osteoblast carbohydrate and amino acid metabolism with respect to bone anabolism; and (iv) the role of AMP‐activated protein kinase in chondrocyte energetic and biomechanical stress responses in the context of cartilage injury, aging, and OA. Although challenges exist for measuring in vivo changes in synovial joint tissue metabolism, the findings presented herein provide multiple lines of evidence to support a central role for disrupted cellular energy metabolism in the pathogenesis of OA. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2048–2058, 2016.
To Be or Not to Be in Thrall to the March of Smart Products
Authors: Schweitzer Fiona , Van den Hende Ellis A. 
Published: September 2016

ABSTRACTThis article explores how perceived disempowerment impacts the intention to adopt smart autonomous products. Empirically, the paper builds on three studies to show this impact. Study 1 explores the relevance of the perceived disempowerment in respect of smart autonomous products. Study 2 manipulates autonomy of smart products and finds that perceived disempowerment mediates the link between smart products’ autonomy and adoption intention. Study 3 indicates that an intervention design―that is, a product design that allows consumers to intervene in the actions of an autonomous smart product―can reduce their perceived disempowerment in respect of autonomous smart products. Further, Study 3 reveals that personal innovativeness moderates the role that an intervention design plays in product adoption: an intervention design shows a positive effect on adoption intention for individuals with low personal innovativeness, but for those with high personal innovativeness no effect of an intervention design is present on adoption intention. The authors suggest that managers consider consumers’ perceived disempowerment when designing autonomous smart products, because (1) perceived disempowerment reduces adoption and (2) when targeted at consumers with low personal innovativeness, an intervention design reduces their perceived disempowerment.
Numerical approximations for a phase field dendritic crystal growth model based on the invariant energy quadratization approach
Authors: Zhao Jia , Wang Qi , Yang Xiaofeng 
Published: September 2016

SummaryWe present two accurate and efficient numerical schemes for a phase field dendritic crystal growth model, which is derived from the variation of a free‐energy functional, consisting of a temperature dependent bulk potential and a conformational entropy with a gradient‐dependent anisotropic coefficient. We introduce a novel Invariant Energy Quadratization approach to transform the free‐energy functional into a quadratic form by introducing new variables to substitute the nonlinear transformations. Based on the reformulated equivalent governing system, we develop a first and a second order semi‐discretized scheme in time for the system, in which all nonlinear terms are treated semi‐explicitly. The resulting semi‐discretized equations consist of a linear elliptic equation system at each time step, where the coefficient matrix operator is positive definite and thus, the semi‐discrete system can be solved efficiently. We further prove that the proposed schemes are unconditionally energy stable. Convergence test together with 2D and 3D numerical simulations for dendritic crystal growth are presented after the semi‐discrete schemes are fully discretized in space using the finite difference method to demonstrate the stability and the accuracy of the proposed schemes. Copyright © 2016 John Wiley & Sons, Ltd.
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
Authors: Remnestål Julia , Just David , Mitsios Nicholas , Fredolini Claudia , Mulder Jan , Schwenk Jochen M , Uhlén Mathias , Kultima Kim , Ingelsson Martin , Kilander Lena , Lannfelt Lars , Svenningsson Per , Nellgård Bengt , Zetterberg Henrik , Blennow Kaj , Nilsson Peter , Häggmark‐Månberg Anna 
Published: September 2016

PurposeThis study is part of a larger effort aiming to expand the knowledge of brain‐enriched proteins in human cerebrospinal fluid (CSF) and to provide novel insight into the relation between such proteins and different neurodegenerative diseases.Experimental designHere 280 brain‐enriched proteins in CSF from patients with Alzheimer's disease (AD), Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are profiled. In total, 441 human samples of ventricular CSF collected post mortem and lumbar CSF collected ante mortem are analyzed using 376 antibodies in a suspension bead array setup, utilizing a direct labelling approach.ResultsAmong several proteins displaying differentiated profiles between sample groups, we focus here on two synaptic proteins, neuromodulin (GAP43) and neurogranin (NRGN). They are both found at elevated levels in CSF from AD patients in two independent cohorts, providing disease‐associated profiles in addition to verifying and strengthening previously observed patterns. Increased levels are also observed for patients for whom the AD diagnosis was not established at the time of sampling.Conclusions and clinical relevanceThese findings indicate that analyzing the brain‐enriched proteins in CSF is of particular interest to increase the understanding of the CSF proteome and its relation to neurodegenerative disorders. In addition, this study lends support to the notion that measurements of these synaptic proteins could potentially be of great relevance in future diagnostic tests for AD.
TGF‐β Effects on Prostate Cancer Cell Migration and Invasion Require FosB
Authors: Barrett Cachétne S.X. , Millena Ana C. , Khan Shafiq A. 
Published: September 2016

BACKGROUNDActivator Protein‐1 (AP‐1) family (cJun, JunB, JunD, cFos, FosB, Fra1, and Fra2) plays a central role in the transcriptional regulation of many genes that are associated with cell proliferation, differentiation, migration, metastasis, and survival. Many oncogenic signaling pathways converge at the AP‐1 transcription complex. Transforming growth factor beta (TGF‐β) is a multifunctional regulatory cytokine that regulates many aspects of cellular function, including cellular proliferation, differentiation, migration, apoptosis, adhesion, angiogenesis, immune surveillance, and survival.METHODSThis study investigated, the role of FOS proteins in TGF‐β signaling in prostate cancer cell proliferation, migration, and invasion. Steady state expression levels of FOS mRNA and proteins were determined using RT‐PCR and western blotting analyses. DU145 and PC3 prostate cancer cells were exposed to TGF‐β1 at varying time and dosage, RT‐PCR, western blot, and immunofluorescence analyses were used to determine TGF‐β1 effect on FOS mRNA and protein expression levels as well as FosB subcellular localization. Transient silencing of FosB protein was used to determine its role in cell proliferation, migration, and invasion.RESULTSOur data show that FOS mRNA and proteins were differentially expressed in human prostate epithelial (RWPE‐1) and prostate cancer cell lines (LNCaP, DU145, and PC3). TGF‐β1 induced the expression of FosB at both the mRNA and protein levels in DU145 and PC3 cells, whereas cFos and Fra1 were unaffected. Immunofluorescence analysis showed an increase in the accumulation of FosB protein in the nucleus of PC3 cells after treatment with exogenous TGF‐β1. Selective knockdown of endogenous FosB by specific siRNA did not have any effect on cell proliferation in PC3 and DU145 cells. However, basal and TGF‐β1‐ and EGF‐induced cell migration was significantly reduced in DU145 and PC3 cells lacking endogenous FosB. TGF‐β1‐ and EGF‐induced cell invasion were also significantly decreased after FosB knockdown in PC3 cells.CONCLUSIONOur data suggest that FosB is required for migration and invasion in prostate cancer cells. We also conclude that TGF‐β1 effect on prostate cancer cell migration and invasion may be mediated through the induction of FosB. Prostate 77:72–81, 2017. © 2016 Wiley Periodicals, Inc.
New minimally invasive technique for cystoscopic laser treatment of fetal ureterocele
Authors: Persico N. , Berrettini A. , Fabietti I. , Dallagiovanna C. , Minoli D. , Mosca F. , Fedele L. , Manzoni G. 
Published: September 2016

AbstractPrenatal ultrasound detection of fetal ureterocele with bilateral hydroureteronephrosis, obstruction of the bladder outlet and progressive amniotic fluid reduction have been associated with a significant risk of end‐stage chronic renal disease after birth. Fetal cystoscopic laser incision of the ureterocele, using standard 3.5‐mm fetoscopic access to the amniotic cavity and the fetal bladder with the aim of relieving the bladder outflow obstruction to preserve renal function, has been reported previously in a case with a favorable outcome. We report on two additional cases of fetal ureterocele treated by cystoscopic laser decompression. In the first case, a standard 3.3‐mm uterine entry was used. In the second case, a new approach was adopted using an ‘all‐seeing needle’ 1.6‐mm endoscope. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Protecting and preserving clear barrier layers for flexible packaging materials In‐line thermal evaporation of organic topcoat layer
Authors: Titzmann Antje , Wolff Alexander , Hoffmann Gerd , Trassl Roland 
Published: September 2016

AbstractThe end market for transparent flexible barrier films is larger than for metallized films. Presently, the market is still dominated by polymeric barrier layers but the used chemicals may be harmful for the environment. An alternative would be transparent thin layers deposited by vacuum deposition techniques using reactive processes. Ceramic materials like silicon oxide or aluminum oxide are used having a film thickness of just ∼10 nm, a coating uniformity of +/−5% across and along the film at a barrier performance below 2.0 sccm/m2d for oxygen transmission rate (OTR) and below 1.0 g/m2d for water vapor transmission rate (WVTR) on PET substrates.In this paper, details will be provided about the deposition processes for these barrier layers using thermal evaporation, plasma‐assisted thermal evaporation as well as deposition by electron beam evaporation.An important factor for these high barrier transparent coatings is also to withstand the downstream processes in the whole packaging stream like slitting, lamination, printing etc. One solution is to protect the barrier layers by a Topcoat. For example, off‐line deposition of lacquers is used in field but the market penetration is low due to high process and material costs. An in‐situ Topcoat deposition is a smart solution to overcome this issue saving time and costs. Such an approach will be also described in the presentation and the impact on the performance of the final package will be discussed.
Roll‐to‐Roll processing of flexible devices and components
Authors: Morrison Neil A. 
Published: September 2016

AbstractNext generation consumer electronic devices, including wearables are placing an ever increasing emphasis on form factor. This has resulted in an increase in the number of polymeric films used in their construction. As most of these polymeric materials are initially manufactured in the form of a roll, there has been a drive towards the utilization of so called roll‐to‐roll processing (R2R) in order to reduce both manufacturing line setup, cleanroom and materials costs. This paper will therefore describe some of the most important advances made in this field, including improvements in stack processing for the production of ITO based touch panel devices, the development of new processing platforms for high performance, low defectivity stacks for barrier film & patterning for R2R manufacture of thin film transistors.
Roll‐to‐roll coating of flexible glass
Authors: Deus Carsten , Salomon Jaroslava , Wehner Uwe 
Published: September 2016

AbstractFlexible glass is a relatively new kind of substrate with a unique combination of properties that are, in different aspects, ideal for numerous applications. The material has aroused significant interest and has prompted activities in R&D communities dedicated to topics such as flexible electronics, flexible OLED and flexible PV. As a result, device demonstrators of considerable maturity have been created, some of which were even manufactured using a roll‐to‐roll (R2R) process. So far, these activities have not resulted in marketable final products that are produced in an industrial context.The key prerequisite for a widespread industrial adoption of R2R processing of flexible glass substrates is the availability of suitable and proven manufacturing equipment. The tools need to be able to handle and process this delicate material, taking into account its mechanical properties, which differ significantly from the typical flexible substrates such as paper, polymer film, or metal foil.This article discusses specific equipment aspects that need to be considered in the R2R handling of flexible glass, both in general and by taking the example of a roll‐to‐roll lab coating system. This tool has been designed specifically for handling flexible glass and will be available to the interested community from October 2016.Furthermore, it is shown how different processes such as R2R sputtering, evaporation, and flash lamp annealing can be used for potential flexible glass applications in flexible electronics, architecture, and energy conversion devices. Beyond that, related layer stacks deposited by vacuum coating will be discussed.
The Presence of Serum p53 Antibody Predicts the Pathological Tumor Response to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and Fluorouracil (DCF) in Esophageal Squamous Cell Carcinoma
Authors: Hiyoshi Yukiharu , Yoshida Naoya , Watanabe Masayuki , Kurashige Junji , Baba Yoshifumi , Sakamoto Yasuo , Baba Hideo 
Published: September 2016

AbstractBackgroundDocetaxel, cisplatin and fluorouracil (DCF) is a candidate neoadjuvant chemotherapy (NAC) regimen for esophageal squamous cell carcinoma (ESCC). Although the efficacy and safety of DCF have been reported, the markers that predict the patient’s response are still unknown. The aim of this study was to identify the predictive markers for a response to NAC with DCF in patients with ESCC.MethodsA total of 79 patients who received preoperative DCF followed by esophagectomy between August 2008 and December 2014 were enrolled in this study. All of the patients completed 2 preoperative courses of DCF. The clinical and pathological responses to DCF were investigated, and the associations between the pathological response, the clinicopathological factors and the prognosis were retrospectively analyzed.ResultsAmong the 79 patients, the pathological response to DCF (evaluated according to the Japanese Classification of Esophageal Cancer) was grade 3 (complete pathological response) in 7 patients (8.9 %), grade 2 in 13 patients (16.5 %), grade 1b in 8 patients (10.1 %) and grade 1a in 51 patients (64.6 %). A good pathological response (grade 2–3) was significantly associated with both favorable disease‐free survival (P = 0.0051) and favorable cancer‐specific survival (P = 0.0366). A multivariate analysis revealed that a good clinical response (HR 13.743, 95 % CI 2.455–76.917) and the presence of serum p53 antibody before treatment (HR 3.987, 95 % CI 1.103–14.416) were independent predictors of good pathological response.ConclusionsThe presence of serum p53 antibody can be used as a novel, noninvasive predictor of the pathological tumor response to NAC with DCF in ESCC patients.
Rational design of foundations on soil reinforced by columns
Authors: Bouassida Mounir 
Published: September 2016

Abstract
This paper presents a review of the book titled “Design of column-reinforced foundations” that I recently published. The design of foundations on reinforced soil by columns is tackled within a general framework, where several aspects are taken into consideration: modeling of reinforced soil, bearing capacity, settlement, acceleration of consolidation, and improvement of soil characteristics with selected case histories. Unlike existing books on unique improvement techniques (deep soil mixing, stone columns, sand compaction piles) that focus on installation and equipment issues, this one-of-a-kind guide details design purpose. This book rationally handles the design of column-reinforced foundations (CRF) from modeling up to the study of behavior predicted by the numerical analysis and assessed by the field test results. Quasi-exact solutions of the ultimate bearing capacity of soil reinforced by a trench are suggested. The analytical solutions for predicting the settlement of CRF assuming the linear elastic behavior of constituents of soil reinforced by a group of columns are proposed. A novel methodology for the design of CRF is presented and illustrated by different study cases. The improvement of properties of the initial soil due to the installation of stone columns has been evidenced using numerical and experimental investigations. The behavior of foundations resting on soil reinforced by columns has been predicted by numerical 2D and 3D codes. Related results have been assessed after in situ data.
Internal solitary waves in a two-fluid system with a free surface
Authors: Kodaira Tsubasa , Waseda Takuji , Miyata Motoyasu , Choi Wooyoung 
Published: September 2016

Internal solitary waves in a system of two fluids, silicone oil and water, bounded above by a free surface are studied both experimentally and theoretically. By adjusting an extra volume of silicone oil released from a reservoir, a wide range of amplitude waves are generated in a wave tank. Wave profiles as well as wave speeds are measured using multiple wave probes and are then compared with both the weakly nonlinear Korteweg–de Vries (KdV) models and the strongly nonlinear Miyata–Choi–Camassa (MCC) models. As the density difference between the two fluids in the experiment is relatively small (approximately 14 %), but non-negligible, special attention is paid to the effect of the boundary condition at the top surface. The nonlinear models valid for rigid-lid (RL) and free-surface (FS) boundary conditions are considered separately. It is found that the solitary wave of the FS model for a given amplitude is consistently narrower than that of the RL model and it propagates at a slightly lower speed. Due to strong nonlinearity in the internal-wave motion, the weakly nonlinear KdV models fail to describe the measured internal solitary wave profiles of intermediate and large wave amplitudes. The strongly nonlinear MCC-FS model agrees better with the measurements than the MCC-RL model, which indicates that the free-surface boundary condition at the top surface is crucial in describing the internal solitary waves in the experiment correctly. Leaving the top surface free in the experiment allows us to observe small and relatively short wave packets on the top surface, particularly when the amplitude of the internal solitary wave is large. Once excited, the wave packet is located above the front half of the internal solitary wave and propagates with a speed close to that of the internal solitary wave underneath. A simple resonance mechanism between short surface waves and long internal waves without and with nonlinear effects is examined to estimate the characteristic wavelength of modulated short surface waves, which is found to be in good agreement with the observed wavelength when nonlinearity is taken into account. Using ray theory, the evolution of short surface waves in the presence of a background current induced by an internal solitary wave is also investigated to examine the location of the modulated surface wave packet.
Demand-driven Service Innovation: Discovery and Analysis in Chinese Law Libraries
Authors: Ming Liu 
Published: September 2016

AbstractThis article introduces readers to a new perspective on meeting library user needs. The author employs Kano theory to examine library user demands in Chinese law libraries and how law libraries in China have tried to meet user needs on three different levels. The Kano model was first introduced by Professor Noriaki Kano of Tokyo Rika University. The model was based on the assumption that customer needs are constantly changing and the question becomes how to meet library users’ evolving demands. The article summarizes demands of Chinese law library patrons on three levels: basic needs, performance, and excitement demands. Currently, most Chinese academic law libraries meet the basic needs of library users, but they need to further enhance user satisfaction and promote the law libraries’ status as a legal information center instead of merely a place to collect and house books.