bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rfx2 stabilizes Foxj1 binding at chromatin loops to enable multiciliated cell gene expression
Authors: Quigley Ian K , Kintner Chris 
Published: November 2016

AbstractCooperative transcription factor binding at cis-regulatory sites in the genome drives robust eukaryotic gene expression, and many such sites must be coordinated to produce coherent transcriptional programs. The transcriptional program leading to motile cilia formation requires members of the DNA-binding forkhead (Fox) and Rfx transcription factor families and these factors co-localize to cilia gene promoters, but it is not clear how many cilia genes are regulated by these two factors, whether these factors act directly or indirectly, or how these factors act with specificity in the context of a 3-dimensional genome. Here, we use genome-wide approaches to show that cilia genes reside at the boundaries of topological domains and that these areas have low enhancer density. We show that the transcription factors Foxj1 and Rfx2 binding occurs in the promoters of more cilia genes than other known cilia transcription factors and that while Rfx2 binds directly to promoters and enhancers equally, Foxj1 prefers direct binding to enhancers and is stabilized at promoters by Rfx2. Finally, we show that Rfx2 and Foxj1 lie at the anchor endpoints of chromatin loops, suggesting that target genes are activated when Foxj1 bound at distal sites is recruited via a loop created by Rfx2 binding at both sites. We speculate that the primary function of Rfx2 is to stabilize distal enhancers with proximal promoters by operating as a scaffolding factor, bringing key regulatory domains bound by Foxj1 into close physical proximity and enabling coordinated cilia gene expression.Author SummaryThe multiciliated cell extends hundreds of motile cilia to produce fluid flow in the airways and other organ systems. The formation of this specialized cell type requires the coordinated expression of hundreds of genes in order to produce all the protein parts motile cilia require. While a relatively small number of transcription factors has been identified that promote gene expression during multiciliate cell differentiation, it is not clear how they work together to coordinate the expression of genes required for multiple motile ciliation. Here, we show that two transcription factors known to drive cilia formation, Foxj1 and Rfx2, play complementary roles wherein Foxj1 activates target genes but tends not to bind near them in the genome, whereas Rfx2 can’t activate target genes by itself but instead acts as a scaffold by localizing Foxj1 to the proper targets. These results suggest not only a mechanism by which complex gene expression is coordinated in multiciliated cells, but also how transcriptional programs in general could be modular and deployed across different cellular contexts with the same basic promoter configuration.
OSCAR Foundation: empowering lives through football
Authors: Varghese Elsa , Galliara Meena , Srivastava Manjari 
Published: November 2016

Subject area
Social entrepreneurship, Social enterprise.

Study level/applicability
Masters Programme in Social Entrepreneurship, Social Work, Business Administration; Management Development Programme for Social Entreprenuers.

Case overview
Organisation for Social Change, Awareness and Responsibility (OSCAR) Foundation is a non-profit organisation registered in 2010 under the Bombay Public Trust Act, 1950. Born and raised in the slum colony of Ambedkar Nagar, Cuffe Parade, Ashok, the founder, grew up seeing his friends becoming a victim to many socially inappropriate behaviours due to dropping out of school. Inspired by the thought of breaking this vicious cycle, Ashok used football as a mechanism to instil essential life skills among children and youth and encouraged them to continue their education. The success of his pilot motivated him to set up OSCAR. Presently, through its various programmes, the organisation has reached out to more than 3,000 marginalised children and 500 youths and aims to reach out to 20,000 children by 2020. The case highlights the struggles of Ashok’s entrepreneurial journey and maps the new challenges in scaling up his enterprise.

Expected learning outcomes
The expected learning outcomes are as follows: to identify the characteristics of a social entrepreneur and ascertain the leadership skills required by a social entrepreneur; to scrutinise the life cycle of a social enterprise and develop insights to examine the unique risks and challenges faced at the start-up phase of the social enterprise; and to enhance the understanding of interrelationship between passion, mission focus and challenges to attain financial sustainability for a social venture.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 3: Entrepreneurship.
Evaluation of employee profiles using a hybrid clustering and optimization model
Authors: Esmaeilzadeh Mahsan , Abdollahi Bijan , Ganjali Asadallah , Hasanpoor Akbar 
Published: November 2016

Purpose
The purpose of this paper is to introduce an evaluation methodology for employee profiles that will provide feedback to the training decision makers. Employee profiles play a crucial role in the evaluation process to improve the training process performance. This paper focuses on the clustering of the employees based on their profiles into specific categories that represent the employees’ characteristics. The employees are classified into following categories: necessary training, required training, and no training. The work may answer the question of how to spend the budget of training for the employees. This investigation presents the use of fuzzy optimization and clustering hybrid model (data mining approaches) as a fuzzy imperialistic competitive algorithm (FICA) and k-means to find the employees’ categories and predict their training requirements.

Design/methodology/approach
Prior research that served as an impetus for this paper is discussed. The approach is to apply evolutionary algorithms and clustering hybrid model to improve the training decision system directions.

Findings
This paper focuses on how to find a good model for the evaluation of employee profiles. The paper introduces the use of artificial intelligence methods (fuzzy optimization (FICA) and clustering techniques (K-means)) in management. The suggestion and the recommendations were constructed based on the clustering results that represent the employee profiles and reflect their requirements during the training courses. Finally, the paper proved the ability of fuzzy optimization technique and clustering hybrid model in predicting the employee’s training requirements.

Originality/value
This paper evaluates employee profiles based on new directions and expands the implication of clustering view in solving organizational challenges (in TCT for the first time).
Business leadership for peace
Authors: Ledbetter Bernice 
Published: November 2016

Purpose
The purpose of this paper is to describe what business leaders can do to promote peace. The paper begins by reviewing the salient literature on business and peace and adding to this discussion, leadership concepts that enrich an understanding of the role of business in promoting peace. Using a case example of a business leader committed to advancing peace, the paper introduces the concept of a theory of change to describe the process of transformation business leaders can take to promote peace.

Design/methodology/approach
This conceptual paper draws on literature from business and peace and adds literature from the field of leadership studies to enrich the discussion of business and peace.

Findings
This paper suggests business leaders promoting peace can take action using a theory of change that includes the application of participative and ethical leadership, strategy that embeds peace goals and the use of entrepreneurships in buffer conditions to mitigate identity-based conflict between opposing groups. By understanding a leader’s theory of change, insight is gained on transformational change in promoting peace.

Originality/value
This paper adds to the theoretical and practical discussion on business and peace by including leadership concepts and the concept of a theory of change as a way to describe business leadership for peace.
Modelling foreign exchange rate transaction exposure of UK insurance companies
Authors: Amer Islam 
Published: November 2016

Purpose
The purpose of this paper is to study the sensitivity of foreign exchange exposure through the cash flow estimation method using a sample of 59 UK insurance companies. This approach allows a decomposition of exposures into short- and long-term components. By revealing the nature of their cash flow exposures, companies can evaluate the effectiveness of their hedging programmes and focus their hedging efforts according to the nature of their exposures.

Design/methodology/approach
Martin and Mauer’s (2003, 2005) three-stage model is used to estimate foreign exchange rate transaction exposures for the sample of 65 UK insurance companies over the period 2004-2013. However, this paper has one important innovation to this method. Instead of the model used in previous papers, the paper uses a model from the actuarial field that was proposed by Blum et al. (2001) for modelling foreign exchange rates with their relevant constituents (inflation and interest rate).

Findings
The evidence shows that the currency transaction exposure for non-life insurers is greater than that of life insurers. Moreover, the author finds that large insurers exhibit lower frequencies of foreign exchange transaction exposure than small insurers.

Originality/value
The value of this paper comes from the fact that revealing the nature of cash flow exposures, companies can evaluate the effectiveness of their hedging programmes and focus their hedging efforts according to the nature of their exposures.
Sensitivity of stock indices to global events: the perspective for Pakistani Canadians
Authors: Yeung Wing Him , Aman Asad 
Published: November 2016

Purpose
This paper compares the performance and volatility of the Toronto Stock Exchange in Canada and the Karachi Stock Exchange in Pakistan, as well as the sensitivities of the two stock exchanges to major global events. The purpose of this paper is to assist the Pakistani immigrants in Canada in their investment decisions.

Design/methodology/approach
This paper uses the generalized autoregressive conditional heteroskedasticity model to estimate volatility of the two stock exchanges. Moreover, the mean adjusted returns approach associated with the event study methodology is used to find out the impact of major global events on these stock exchanges.

Findings
The study finds that the Toronto Stock Exchange outperforms the Karachi Stock Exchange in the pre-September 11 attack period, while the latter outperforms the former in the post-September 11 attack period. The study also shows that there has been a significant improvement in the risk-adjusted return of the Karachi Stock Exchange in the post-September 11 attack period. Moreover, this paper finds that the impact of major global events is more significant on the Toronto Stock Exchange relative to the Karachi Stock Exchange on the event date.

Originality/value
This paper is one of the very few to analyze and compare stock performances from the perspective of immigrant communities. The paper is valuable for Pakistani immigrants living in Canada or any investors interested in Karachi Stock Exchange and its comparison with Toronto Stock Exchange. Moreover, the paper can be of value to the Pakistani Government in terms of their promotional activities.
The influence of EWOM characteristics on online repurchase intention
Authors: Matute Jorge , Polo-Redondo Yolanda , Utrillas Ana 
Published: November 2016

Purpose
With the expansion of internet as a tool for exchanging information, companies include in their websites a virtual space to share information among users. The purpose of this paper is to explore the characteristics of consumers’ reviews (electronic word-of-mouth quantity, credibility and quality) as antecedents of customers’ online repurchase intentions. Specially, it proposes a model where trust on an online seller and perceived usefulness of a website mediate the influence of electronic word-of-mouth (EWOM) characteristics on repurchase intentions.

Design/methodology/approach
Structural equation modeling was employed on a sample of 252 online customers. An online questionnaire was aimed at internet users who had previously made an online purchase and read online reviews received from the vendor’s website.

Findings
Results show that only EWOM quality has a positive direct effect on consumers’ repurchase intention while quantity has a negative influence. Perceived usefulness mediates the influence of all EWOM characteristics on online repurchase intention. EWOM credibility and quality also indirectly influence repurchase intentions through trust on the online vendor.

Practical implications
This paper outlines ways to improve managerial implications by developing mobile applications or websites where the reviews have an appropriate volume and quality of information. Moreover, it suggests general advice to present online reviews in a useful manner to users who visit these websites.

Originality/value
This study is one of the first to propose an integrative model that studies in depth the three main EWOM characteristics and customer responses for understanding their repurchase behavior.
Knowledge discovery from within
Authors: Force Donald C. , Zhang Jane 
Published: November 2016

Purpose
The purpose of this paper is to report the findings of a research project that analyzed records management (RM) and electronic records management (ERM) course syllabi from North American archival studies’ programs. By identifying the convergences and divergences of the topics and literature found within the syllabi, the authors sought to understand the relationship between the two courses and gain insight about how these courses continue to serve as an integral component of archival studies education.

Design/methodology/approach
The paper is based on a qualitative analysis of 23 RM and 12 ERM course syllabi from 26 academic institutions from North America. The research examined three different aspects of the syllabi: textbooks, required articles and weekly topics. The syllabi were analyzed as separate data sets (RM syllabi and ERM syllabi), which was followed by a comparative analysis of the two types of syllabi.

Findings
The findings of this study reveal that RM, ERM and (to a lesser extent) DA (digital archives) knowledge as represented in archival education converges in some course contents but diverges in others. Archival educators should pay close attention to overlapping areas so that the courses can better complement each other and advance knowledge representation within archival studies.

Research limitations/implications
This study only considered graduate-level programs in the USA and Canada. The study did not include syllabi or instructional guides from associate-level programs or professional organizations such as the International Certification of Records Managers or Association of Records Managers and Administrators (ARMA) International.

Practical implications
The results of this study lead the authors to present two different approaches for how RM and ERM knowledge may be incorporated into archival curriculum.

Originality/value
This is the first research project to analyze RM and ERM syllabi with regards to the enhancement of records and information management education and archival curriculum development.
Cultivating capability
Authors: Jones Michael , Vines Richard 
Published: November 2016

Purpose
This paper aims to advocate that significant human and systems-based capabilities (termed “socio-technical capabilities”) need to be developed in government departments and other public sector organisations to support more effective description of information resources, collections and their context in online environments.

Design/methodology/approach
The ideas in this paper draw upon the findings of several action research interventions undertaken within a government department in Victoria in Australia since 2011 as part of a knowledge management initiative. Specific focus is given to the design and development of a new record-centric knowledge curation tool (KCT).

Findings
Effective functioning of KCT relies upon the input of well-structured, standards-based metadata used to describe collections, information resources and their context. The central claim is that the move towards standards-based descriptions will fundamentally change the capabilities required to manage, search for and disseminate knowledge and records.

Research limitations/implications
In addition to the capabilities discussed, management of records and knowledge through time requires commitments to stable repository, workflow and administrative systems, and working with contemporary systems involves technical knowledge such as the use of application programming interfaces. These aspects are not discussed here.

Practical implications
The capabilities discussed in this paper are socio-technical in nature. This means there is a requirement to shift current perspectives about who is responsible for managing organisational information as collections.

Originality/value
While some of the concepts discussed will be familiar to information professionals, the paper provides a unique description of how existing archival and recordkeeping practices are being integrated in innovative ways within organisations outside the information management professions.
Immediate delivery or expectant management in gestational diabetes at term: the GINEXMAL randomised controlled trial
Authors: Alberico S , Erenbourg A , Hod M , Yogev Y , Hadar E , Neri F , Ronfani L , Maso G ,   the GINEXMAL Group
Published: November 2016

ObjectiveTo evaluate maternal and perinatal outcomes after induction of labour versus expectant management in pregnant women with gestational diabetes at term.DesignMulticentre open‐label randomised controlled trial.SettingEight teaching hospitals in Italy, Slovenia, and Israel.SampleSingleton pregnancy, diagnosed with gestational diabetes by the International Association of Diabetes and Pregnancy Study Groups criteria (IADPSGC), between 38+0 and 39+0 weeks of gestation, without other maternal or fetal conditions.MethodsPatients were randomly assigned to induction of labour or expectant management and intensive follow‐up. Data were analysed by ‘intention to treat’.Main outcome measuresThe primary outcome was incidence of caesarean section. Secondary outcomes were maternal and perinatal mortality and morbidity.ResultsA total of 425 women were randomised to the study groups. The incidence of caesarean section was 12.6% in the induction group versus 11.7% in the expectant group. No difference was found between the two groups (relative risk, RR 1.06; 95% confidence interval, 95% CI 0.64–1.77; P = 0.81). The incidence of non‐spontaneous delivery, either by caesarean section or by operative vaginal delivery, was 21.0 and 22.3%, respectively (RR 0.94; 95% CI 0.66–1.36; P = 0.76). Neither maternal nor fetal deaths occurred. The few cases of shoulder dystocia were solved without any significant birth trauma.ConclusionsIn women with gestational diabetes, without other maternal or fetal conditions, no difference was detected in birth outcomes regardless of the approach used (i.e. active versus expectant management). Although the study was underpowered, the magnitude of the between‐group difference was very small and without clinical relevance.Tweetable abstractImmediate delivery or expectant management in gestational diabetes at term?
Strengthening Post‐Crisis Fiscal Credibility: Fiscal Councils on the Rise – A New Dataset
Authors: Debrun Xavier , Kinda Tidiane 
Published: November 2016

AbstractInstitutions that aim to constrain policy discretion in order to promote sound fiscal policies are once again at the forefront of the policy debate. Interest in fiscal councils – independent watchdogs active in the public debate – has grown rapidly in recent years. In this paper, we present the first cross‐country dataset summarising key characteristics of fiscal councils among International Monetary Fund members. The data document a surge in the number of fiscal councils since the 2008–09 economic and financial crisis, and also illustrate that well‐designed fiscal councils are associated with stronger fiscal performance and better macro‐economic and budgetary forecasts. Key features of effective fiscal councils include operational independence from politics, the provision or public assessment of budgetary forecasts, a strong presence in the public debate and the monitoring of compliance with fiscal policy rules.
Proteins of Amaranth (Amaranthus spp.), Buckwheat (Fagopyrum spp.), and Quinoa (Chenopodium spp.): A Food Science and Technology Perspective
Authors: Janssen Frederik , Pauly Anneleen , Rombouts Ine , Jansens Koen J.A. , Deleu Lomme J. , Delcour Jan A. 
Published: November 2016

AbstractThere is currently much interest in the use of pseudocereals for developing nutritious food products. Amaranth, buckwheat, and quinoa are the 3 major pseudocereals in terms of world production. They contain high levels of starch, proteins, dietary fiber, minerals, vitamins, and other bioactives. Their proteins have well‐balanced amino acid compositions, are more sustainable than those from animal sources, and can be consumed by patients suffering from celiac disease. While pseudocereal proteins mainly consist of albumins and globulins, the predominant cereal proteins are prolamins and glutelins. We here discuss the structural properties, denaturation and aggregation behaviors, and solubility, as well as the foaming, emulsifying, and gelling properties of amaranth, buckwheat, and quinoa proteins. In addition, the technological impact of incorporating amaranth, buckwheat, and quinoa in bread, pasta, noodles, and cookies and strategies to affect the functionality of pseudocereal flour proteins are discussed. Literature concerning pseudocereal proteins is often inconsistent and contradictory, particularly in the methods used to obtain globulins and glutelins. Also, most studies on protein denaturation and techno‐functional properties have focused on isolates obtained by alkaline extraction and subsequent isoelectric precipitation at acidic pH, even if the outcome of such studies is not necessarily relevant for understanding the role of the native proteins in food processing. Finally, even though establishing in‐depth structure–function relationships seems challenging, it would undoubtedly be of major help in the design of tailor‐made pseudocereal foods.