bluuebunny/crossref_metadata_2025_split huggingface dataset:
Literacy acquisition influences children's rapid automatized naming
Authors: Peterson Robin L. , Arnett Anne B. , Pennington Bruce F. , Byrne Brian , Samuelsson Stefan , Olson Richard K. 
Published: August 2017

AbstractPrevious research has established that learning to read improves children's performance on reading‐related phonological tasks, including phoneme awareness (PA) and nonword repetition. Few studies have investigated whether literacy acquisition also promotes children's rapid automatized naming (RAN). We tested the hypothesis that literacy acquisition should influence RAN in an international, longitudinal population sample of twins. Cross‐lagged path models evaluated the relationships among literacy, PA, and RAN across four time points from pre‐kindergarten through grade 4. Consistent with previous research, literacy showed bidirectional relationships with reading‐related oral language skills. We found novel evidence for an effect of earlier literacy on later RAN, which was most evident in children at early phases of literacy development. In contrast, the influence of earlier RAN on later literacy was predominant among older children. These findings imply that the association between these two related skills is moderated by development. Implications for models of reading development and for dyslexia research are discussed.
The relationship between periodontal disease, tooth loss and decreased skeletal bone mineral density in ageing women
Authors: Savić Pavičin Ivana , Dumančić Jelena , Jukić Tomislav , Badel Tomislav 
Published: August 2017

AimOsteoporosis and periodontitis are both chronic diseases characterised by bone loss. Potential association is of great clinical importance because of multifactorial aetiology and common risk factors. The aim of this study was to determine relationship between bone mineral density (BMD), tooth loss and periodontal status taking into account age, number of years since onset of menopause and educational level. With increasing age, number of years since onset of menopause and lower educational level, decreased BMD, deteriorating periodontal status and greater tooth loss are expected.Materials and methodsCross‐sectional study included 112 women aged 45‐80 years (mean 58.3 years). BMD was determined for lumbar spine region and proximal femur by DEXA technology. Dental status and periodontal status were evaluated clinically and on panoramic radiographs. For the analysis of tooth loss frequency, participants were divided into four age groups.ResultsSignificant inverse correlation was found between number of lost teeth and BMD at hip region (r = −.227; P = .028) but not at the lumbar spine (r = −.05; P = .669). Several indicators of the periodontal condition were significantly correlated with BMD, but not with postmenopausal period length. Important result is that participants missing one or more incisors or canines had significantly lower mean value of BMD comparing to those who had all the incisors and canines remained.ConclusionAlthough osteoporosis is not the main cause of periodontitis, it may be a factor that leads to enhanced periodontal pocket depth and greater risk of tooth loss in ageing women.
Black and minority ethnic group involvement in health and social care research: A systematic review
Authors: Dawson Shoba , Campbell Stephen M. , Giles Sally J. , Morris Rebecca L. , Cheraghi‐Sohi Sudeh 
Published: August 2017

AbstractBackgroundPatient and public involvement (PPI) in research is growing internationally, but little is known about black and minority ethnic (BME) involvement and the factors influencing their involvement in health and social care research.ObjectivesTo characterize and critique the empirical literature on BME‐PPI involvement in health and social care research.Search strategySystematic searches of six electronic bibliographic databases were undertaken, utilizing both MeSH and free‐text terms to identify international empirical literature published between 1990 and 2016.Inclusion criteriaAll study designs that report primary data that involved BME groups in health or social care research. Screening was conducted by two reviewers.Data extraction and synthesisData extraction and quality appraisal were performed independently. Data extraction focused on the level(s) of PPI involvement and where PPI activity occurred in the research cycle. Studies were quality‐assessed using the guidelines for measuring the quality and impact of user involvement in research. Data were analysed using a narrative approach.Main resultsForty‐five studies were included with the majority undertaken in the USA focusing on African Americans and indigenous populations. Involvement most commonly occurred during the research design phase and least in data analysis and interpretation.ConclusionThis is the first systematic review investigating BME involvement in health and social care research internationally. While there is a widespread support for BME involvement, this is limited to particular phases of the research and particular ethnic subgroups. There is a need to understand factors that influence BME involvement in all parts of the research cycle.
Parents' adverse childhood experiences and mental health screening using home visiting programs: A pilot study
Authors: Johnson Katie , Woodward Alicia , Swenson Sadie , Weis Christine , Gunderson Margene , Deling Marilyn , Cristiani Valeria , Lynch Brian 
Published: August 2017

AbstractBackgroundAdverse childhood experiences (ACEs) are associated with adult high‐risk behaviors and diseases. There is value in screening parents for ACEs given the repercussions parental ACEs may have on parenting behaviors and child development. The primary aim of this study was to assess the feasibility of parental ACE screening in the home setting. A secondary aim was to evaluate whether or not maternal ACEs correlated with maternal mental health measures.MethodsTwo home visiting programs that support early childhood development and conduct parental mental health screening implemented ACE screening for parents of infants <1 year of age. Descriptive statistics were produced for population surveillance of ACEs as well as standard practice screens for depression, anxiety, substance use, and intimate partner violence. Logistic models were used to examine associations between ACE score and mental health measures.ResultsA total of 110 parents completed the ACE screen. All possible ACE score outcomes were represented (0–10). A trend toward association of positive prenatal maternal depression screen with ACE score was identified (p = .05).ConclusionThis novel prospective home‐based screening program for parental ACEs was feasible and identified a trend toward increasing ACE score association with positive prenatal maternal depression screen.
Social Policy's ‘Greatest Hits’
Authors: Powell Martin 
Published: August 2017

AbstractThe ‘age of metrics’ or ‘the metric tide’ in the form of bibliometrics has largely by‐passed Social Policy. This study aims to broaden the focus from the most cited articles in Social Policy journals to discover the most cited works in Social Policy or ‘Social Policy's Greatest Hits’. It finds some 24 works with over 2000 Google Scholar citations, but only nine of these are by social policy writers. In terms of total citations, Gosta Esping‐Andersen's The Three Worlds of Welfare Capitalism is the clear leader by a significant margin, with the most cited Social Policy (or Social Administration) writers being Peter Townsend, Richard Titmuss, Ruth Lister and Jane Lewis. In addition to total citations, it presents citations per year, and ‘Social Policy citations’ (i.e. the use made of the work within the discipline of Social Policy). This list is headed by Gosta Esping‐Andersen and Paul Pierson, with the leading social policy writer being Jane Lewis. This article presents a set of the ‘most plausible contenders’ for the works with greatest influence within Social Policy or ‘Social Policy's Greatest Hits’. It is concluded that, even with its flaws, bibliometrics is an important approach to exploring the vast field of Social Policy.
Defining the DNA Binding Site Recognized by the Fission Yeast Zn
2
Cys
6
Transcription Factor Pho7 and Its Role in Phosphate Homeostasis
Authors: Schwer Beate , Sanchez Ana M. , Garg Angad , Chatterjee Debashree , Shuman Stewart 
Published: August 2017

ABSTRACT

Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor Pho7, a member of the Zn
2
Cys
6
family of fungal transcription regulators, is the central player in the starvation response. The DNA binding sites in the promoters of phosphate-responsive genes have not been defined, nor have any structure-function relationships been established for the Pho7 protein. Here we narrow this knowledge gap by (i) delineating an autonomous DNA-binding domain (DBD) within Pho7 that includes the Zn
2
Cys
6
module, (ii) deploying recombinant Pho7 DBD in DNase I footprinting and electrophoretic mobility shift assays (EMSAs) to map the Pho7 recognition sites in the promoters of the phosphate-regulated
pho1
and
tgp1
genes to a 12-nucleotide sequence motif [5′-TCG(G/C)(A/T)xxTTxAA], (iii) independently identifying the same motif as a Pho7 recognition element via
in silico
analysis of available genome-wide ChIP-seq data, (iv) affirming that mutations in the two Pho7 recognition sites in the
pho1
promoter efface
pho1
expression
in vivo
, and (v) establishing that the zinc-binding cysteines and a pair of conserved arginines in the DBD are essential for Pho7 activity
in vivo
.

IMPORTANCE
Fungi respond to phosphate starvation by inducing the transcription of a set of phosphate acquisition genes that comprise a phosphate regulon. Pho7, a member of the Zn
2
Cys
6
family of fungal transcription regulators, is the central player in the phosphate starvation response in fission yeast. The present study identifies a 12-nucleotide Pho7 DNA binding motif [5′-TCG(G/C)(A/T)xxTTxAA] in the promoters of phosphate-regulated genes, pinpoints DNA and protein features important for Pho7 binding to DNA, and correlates them with Pho7-dependent gene expression
in vivo
. The results highlight distinctive properties of Pho7 vis-a-vis other fungal zinc binuclear cluster transcription factors as well as the divergent cast of transcription factors deployed for phosphate homeostasis in fission yeast versus budding yeast.
Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb
Authors: Yang Zhe , Maciejowski John , de Lange Titia 
Published: August 2017

Abstract
The mammalian nuclear envelope (NE) forms a stable physical barrier between the nucleus and the cytoplasm, normally breaking down only during mitosis. However, spontaneous transient NE rupture in interphase can occur when NE integrity is compromised, such as when the nucleus experiences mechanical stress. For instance, deficiencies in the nuclear lamins and their associated proteins can cause NE rupture that is promoted by forces exerted by actin filaments. NE rupture can allow cytoplasmic nucleases to access chromatin, potentially compromising genome integrity. Importantly, spontaneous NE rupture was noted in several human cancer cell lines, but the cause of this defect is not known. Here, we investigated the mechanistic contributions of two major tumor suppressors, p53 (TP53) and Rb (RB1), to the repression of NE rupture. NE rupture was induced in normal human epithelial RPE-1 cells upon impairment of either Rb or p53 achieved by shRNA knockdown and CRISPR/Cas9 gene editing. NE rupture did not involve diminished expression of NE components or greater cell motility. However, cells that underwent NE rupture displayed a larger nuclear projection area. In conclusion, the data indicate that NE rupture in cancer cells is likely due to loss of either the Rb or the p53 pathway.
Implications: These findings imply that tumor suppression by Rb and p53 includes the ability to prevent NE rupture, thereby protecting against genome alterations. Mol Cancer Res; 15(11); 1579–86. ©2017 AACR.
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Authors: Emons Georg , Spitzner Melanie , Reineke Sebastian , Möller Janneke , Auslander Noam , Kramer Frank , Hu Yue , Beissbarth Tim , Wolff Hendrik A. , Rave-Fränk Margret , Heßmann Elisabeth , Gaedcke Jochen , Ghadimi B. Michael , Johnsen Steven A. , Ried Thomas , Grade Marian 
Published: August 2017

Abstract
Activation of Wnt/β-catenin signaling plays a central role in the development and progression of colorectal cancer. The Wnt-transcription factor, TCF7L2, is overexpressed in primary rectal cancers that are resistant to chemoradiotherapy and TCF7L2 mediates resistance to chemoradiotherapy. However, it is unclear whether the resistance is mediated by a TCF7L2 inherent mechanism or Wnt/β-catenin signaling in general. Here, inhibition of β-catenin by siRNAs or a small-molecule inhibitor (XAV-939) resulted in sensitization of colorectal cancer cells to chemoradiotherapy. To investigate the potential role of Wnt/β-catenin signaling in controlling therapeutic responsiveness, nontumorigenic RPE-1 cells were stimulated with Wnt-3a, a physiologic ligand of Frizzled receptors, which increased resistance to chemoradiotherapy. This effect could be recapitulated by overexpression of a degradation-resistant mutant of β-catenin (S33Y), also boosting resistance of RPE-1 cells to chemoradiotherapy, which was, conversely, abrogated by siRNA-mediated silencing of β-catenin. Consistent with these findings, higher expression levels of active β-catenin were observed as well as increased TCF/LEF reporter activity in SW1463 cells that evolved radiation resistance due to repeated radiation treatment. Global gene expression profiling identified several altered pathways, including PPAR signaling and other metabolic pathways, associated with cellular response to radiation. In summary, aberrant activation of Wnt/β-catenin signaling not only regulates the development and progression of colorectal cancer, but also mediates resistance of rectal cancers to chemoradiotherapy.
Implications: Targeting Wnt/β-catenin signaling or one of the downstream pathways represents a promising strategy to increase response to chemoradiotherapy. Mol Cancer Res; 15(11); 1481–90. ©2017 AACR.
Nurse researchers’ perspectives on research ethics in China
Authors: Gu Can , Ye Man , Wang Xiaomin , Yang Min , Wang Honghong , Khoshnood Kaveh 
Published: August 2017

Background: In China, research ethics is a subject of increasingly formal regulation. However, little is known about how nursing researchers understand the concept of research ethics and the ways in which they can maintain ethical standards in their work. Aim: The aim of this study is to examine nursing researchers’ perspectives on research ethics in China. Research design: We conducted a descriptive qualitative study. Qualitative research methods enabled us to gain an in-depth understanding of nursing researchers’ views on research ethics. Participants and research context: We carefully selected and extensively interviewed 28 nursing researchers, nursing faculty, and clinical nurses who had been involved in research or who may undertake research in the future. We collected data between October 2014 and March 2015. Ethical considerations: This study was approved by the institutional review boards of Yale University and Central South University. Findings: We grouped the data into five categories based on the interviewees’ responses: (1) perceptions of ethics, bioethics, and research ethics; (2) perception of the ethics review process; (3) perception of the function of institutional review boards; (4) the need for comprehensive ethical guidelines for future studies; and (5) ethical challenges faced by the interviewees. Discussion and conclusion: This study contributes new insights into nursing researchers’ views on research ethics in China and finds considerable shortcomings in researchers’ understanding and implementation of ethical principles. Intensive educational efforts are needed to provide nursing researchers, institutional review board members, and even study subjects with accurate and up-to-date information and guidance on research ethics. In addition, while Western research ethics theoretically have guided Chinese clinical research for several years, the ways in which nursing researchers have implemented these ethical standards highlight the differences between the Eastern and Western ethical paradigms. This finding suggests the need for ethical standards that are more tailored to the Chinese context.
Handmaidens of History? Exploring English, Hindi and Sanskrit Textbooks for Schools
Authors: Roy Kumkum 
Published: August 2017

The article explores the ways in which concerns of history, in terms of content, concepts and methodology, find space or do not find space within textbooks used for teaching languages. These may be more important as sites of ‘knowledge’ than social science books, because the latter are often regarded as insignificant within the formal schooling system.  How are great men (and women) constructed? What are regarded as ‘suitable’ examples of historical achievements? How is change understood and explained? Are there spaces for escaping from a normative, increasingly homogeneous and homogenised understanding of the past dominated by the preoccupations of a visible, majoritarian middle class? These are some of the questions raised.
Kardiovize Brno 2030, a prospective cardiovascular health study in Central Europe: Methods, baseline findings and future directions
Authors: Movsisyan Narine K , Vinciguerra Manlio , Lopez-Jimenez Francisco , Kunzová Šárka , Homolka Martin , Jaresova Jana , Cífková Renata , Sochor Ondřej 
Published: August 2017

Background Atherosclerotic cardiovascular disease is highly prevalent in Eastern and Central Europe, where the incidence is the highest in the world. The Kardiovize Brno 2030 study was designed as a prospective cohort study to investigate the complex relationships of cardiovascular disease and outcomes with a range of biological, psychosocial, environmental, behavioral, and economic factors in an urban population of the Czech Republic. Methods We randomly selected a 1% sample of the city of Brno residents aged 25–64 years stratified by sex and age. The study assessed traditional and novel cardiovascular disease risk factors, including sociodemographic and smoking status, physical activity, diet, depression, stress, body fat, cardio-ankle vascular index, and intima media thickness, complemented by blood tests; biological samples were stored for future analyses. Results The study enrolled 2160 participants (54.8% women), with a mean age of 47 ± 11.3 years. They were mostly full-time employed (75.6%) and married (62.1%). Hyperlipidemia was highly prevalent (70.7% in men, and 67.1% in women, NS). Hypertension and diabetes mellitus were more prevalent in men than in women (54.3% vs. 38.7% and 7.1% vs. 3.5%, respectively, P < 0.001 for both). A total of 25.3% of men and 21.9% of women smoked, whereas 20.0% and 43.0% of men and 18.1% and 26.6% of women were obese and overweight, respectively. Conclusions Cardiovascular risk factors are highly prevalent in the city of Brno, an urban population from Central Europe. The Kardiovize Brno 2030 study will provide unique multidimensional and longitudinal cardiovascular health data from a region where epidemiological studies are scarce.
Measuring the impact of multiple sclerosis: Enhancing the measurement performance of the Multiple Sclerosis Impact Scale (MSIS-29) using Rasch Measurement Theory (RMT)
Authors: Cleanthous Sophie , Cano Stefan , Kinter Elizabeth , Marquis Patrick , Petrillo Jennifer , You Xiaojun , Wakeford Craig , Sabatella Guido 
Published: August 2017

Background Study objectives were to evaluate the Multiple Sclerosis Impact Scale (MSIS-29) and explore an optimized scoring structure based on empirical post-hoc analyses of data from the Phase III ADVANCE clinical trial. Methods ADVANCE MSIS-29 data from six time-points were analyzed in a sample of patients with relapsing–remitting multiple sclerosis (RRMS). Rasch Measurement Theory (RMT) analysis was undertaken to examine three broad areas: sample-to-scale targeting, measurement scale properties, and sample measurement validity. Interpretation of results led to an alternative MSIS-29 scoring structure, further evaluated alongside responsiveness of the original and revised scales at Week 48. Results RMT analysis provided mixed evidence for Physical and Psychological Impact scales that were sub-optimally targeted at the lower functioning end of the scales. Their conceptual basis could also stand to improve based on item fit results. The revised MSIS-29 rescored scales improved but did not resolve the measurement scale properties and targeting of the MSIS-29. In two out of three revised scales, responsiveness analysis indicated strengthened ability to detect change. Conclusion The revised MSIS-29 provides an initial evidence-based improved patient-reported outcome (PRO) instrument for evaluating the impact of MS. Revised scoring improves conceptual clarity and interpretation of scores by refining scale structure to include Symptoms, Psychological Impact, and General Limitations. Clinical trial ADVANCE (ClinicalTrials.gov identifier NCT00906399).
Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma
Authors: Lin Richard J. , Behera Madhusmita , Diefenbach Catherine S. , Flowers Christopher R. 
Published: August 2017

Abstract
Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making.
Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant
Authors: Karaesmen Ezgi , Rizvi Abbas A. , Preus Leah M. , McCarthy Philip L. , Pasquini Marcelo C. , Onel Kenan , Zhu Xiaochun , Spellman Stephen , Haiman Christopher A. , Stram Daniel O. , Pooler Loreall , Sheng Xin , Zhu Qianqian , Yan Li , Liu Qian , Hu Qiang , Webb Amy , Brock Guy , Clay-Gilmour Alyssa I. , Battaglia Sebastiano , Tritchler David , Liu Song , Hahn Theresa , Sucheston-Campbell Lara E. 
Published: August 2017

Key PointsCandidate SNP associations with survival outcomes after URD transplant are most likely false-positive findings. Over 85% of candidate SNPs are not linked to a biochemical function; of those that are, about half are not linked to the candidate gene.