bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postmortem DTI reveals altered hippocampal connectivity in wild sea lions diagnosed with chronic toxicosis from algal exposure
Authors: Cook Peter F. , Berns Gregory S. , Colegrove Kathleen , Johnson Shawn , Gulland Frances 
Published: September 2017

AbstractHundreds of wild California sea lions (Zalophus californianus) exposed to the algal neurotoxin domoic acid are treated in veterinary rehabilitation centers each year. Common chronic effects of toxic exposure in these animals are seizures and hippocampal damage, and they have been proposed as a natural animal model for human epilepsy. Humans with medial temporal lobe epilepsy present with white matter pathology in a number of tracts including the fornix and increased structural connectivity between the hippocampus and thalamus. However, there are no prior data on structural connectivity in sea lion brains, with or without neuropathology. In the present study, we used a novel diffusion tensor imaging technique to obtain high resolution (1mm isotropic) white matter maps in brains obtained opportunistically postmortem from wild sea lions with and without chronic clinical signs of toxic exposure to domoic acid. All animals had received a full veterinary workup and diagnosis prior to euthanasia. We measured hippocampal atrophy morphometrically, and all brains were examined histopathologically. In animals diagnosed with chronic domoic acid toxicosis, the fornix showed signs of altered diffusion properties indicative of pathology; these brains also had increased structural connectivity between hippocampus and thalamus in comparison to brains from animals with no neurological signs. These findings establish further parallels between human medial temporal lobe epilepsy and a naturally occurring condition in wild sea lions and simultaneously advance general knowledge of the deleterious effects of an increasingly common natural toxin.
Ultrathin Composite Polymeric Membranes for CO2/N2 Separation with Minimum Thickness and High CO2 Permeance
Authors: Benito Javier , Sánchez‐Laínez Javier , Zornoza Beatriz , Martín Santiago , Carta Mariolino , Malpass‐Evans Richard , Téllez Carlos , McKeown Neil B. , Coronas Joaquín , Gascón Ignacio 
Published: September 2017

AbstractThe use of ultrathin films as selective layers in composite membranes offers significant advantages in gas separation for increasing productivity while reducing the membrane size and energy costs. In this contribution, composite membranes have been obtained by the successive deposition of approximately 1 nm thick monolayers of a polymer of intrinsic microporosity (PIM) on top of dense membranes of the ultra‐permeable poly[1‐(trimethylsilyl)‐1‐propyne] (PTMSP). The ultrathin PIM films (30 nm in thickness) demonstrate CO2 permeance up to seven times higher than dense PIM membranes using only 0.04 % of the mass of PIM without a significant decrease in CO2/N2 selectivity.
Diphenyl‐2‐pyridylamine‐Substituted Porphyrins as Hole‐Transporting Materials for Perovskite Solar Cells
Authors: Lee Un‐Hak , Azmi Randi , Sinaga Septy , Hwang Sunbin , Eom Seung Hun , Kim Tae‐Wook , Yoon Sung Cheol , Jang Sung‐Yeon , Jung In Hwan 
Published: September 2017

AbstractThe susceptibility of porphyrin derivatives to light‐harvesting and charge‐transport operations have enabled these materials to be employed in solar cell applications. The potential of porphyrin derivatives as hole‐transporting materials (HTMs) for perovskite solar cells (PSCs) has recently been demonstrated, but knowledge of the relationships between the porphyrin structure and device performance remains insufficient. In this work, a series of novel zinc porphyrin (PZn) derivatives has been developed and employed as HTMs for low‐temperature processed PSCs. Key to the design strategy is the incorporation of an electron‐deficient pyridine moiety to down‐shift the HOMO levels of porphyrin HTMs. The porphyrin HTMs incorporating diphenyl‐2‐pyridylamine (DPPA) have HOMO levels that are in good agreement with the perovskite active layers, thus facilitating hole transfers from the perovskite to the HTMs. The DPPA‐containing zinc porphyrin‐based PSCs gave the best performance, with efficiency levels comparable to those of PSCs using spiro‐OMeTAD, a current state‐of‐the‐art HTM. In particular, PZn–DPPA‐based PSCs show superior air stability, in both doped and undoped forms, to spiro‐OMeTAD based devices.
Impact of the RT‐level architecture on the power performance of tunnel transistor circuits
Authors: Avedillo María J. , Núñez Juan 
Published: September 2017

SummaryTunnel field‐effect transistors (TFETs) are one of the most attractive steep subthreshold slope devices currently being investigated as a means of overcoming the power density and energy inefficiency limitations of Complementary Metal Oxide Semiconductor (CMOS) technology. In this paper, we analyze the relationship between devices and register transfer–level architecture choices. We claim that architectural issues should be considered when evaluating this type of transistors because of the differences in delay versus supply voltage behavior exhibited by TFET logic gates with respect to CMOS gates. More specifically, the potential of pipelining and parallelism, both of which rely on lowering supply voltage, as power reduction techniques is evaluated and compared for CMOS and TFET technologies. The results obtained show significantly larger savings in power and energy per clock cycle for the TFET designs than for their CMOS counterparts, especially at low voltages. Pipelining and parallelism make it possibly to fully exploit the distinguishing characteristics of TFETs, and their relevance as competitive TFET circuit design solutions should be explored in greater depth.
ATLANTIC BATS: a data set of bat communities from the Atlantic Forests of South America
Authors: Muylaert Renata d. L. , Stevens Richard D. , Esbérard Carlos E. L. , Mello Marco A. R. , Garbino Guilherme S. T. , Varzinczak Luiz H. , Faria Deborah , Weber Marcelo d. M. , Kerches Rogeri Patricia , Regolin André L. , Oliveira Hernani F. M. d. , Costa Luciana d. M. , Barros Marília A. S. , Sabino‐Santos Gilberto , Crepaldi de Morais Mara Ariane , Kavagutti Vinicius S. , Passos Fernando C. , Marjakangas Emma‐Liina , Maia Felipe G. M. , Ribeiro Milton C. , Galetti Mauro 
Published: September 2017

AbstractBats are the second most diverse mammal order and they provide vital ecosystem functions (e.g., pollination, seed dispersal, and nutrient flux in caves) and services (e.g., crop pest suppression). Bats are also important vectors of infectious diseases, harboring more than 100 different virus types. In the present study, we compiled information on bat communities from the Atlantic Forests of South America, a species‐rich biome that is highly threatened by habitat loss and fragmentation. The ATLANTIC BATS data set comprises 135 quantitative studies carried out in 205 sites, which cover most vegetation types of the tropical and subtropical Atlantic Forest: dense ombrophilous forest, mixed ombrophilous forest, semideciduous forest, deciduous forest, savanna, steppe, and open ombrophilous forest. The data set includes information on more than 90,000 captures of 98 bat species of eight families. Species richness averaged 12.1 per site, with a median value of 10 species (ranging from 1 to 53 species). Six species occurred in more than 50% of the communities: Artibeus lituratus, Carollia perspicillata, Sturnira lilium, Artibeus fimbriatus, Glossophaga soricina, and Platyrrhinus lineatus. The number of captures divided by sampling effort, a proxy for abundance, varied from 0.000001 to 0.77 individuals·h−1·m−2 (0.04 ± 0.007 individuals·h−1·m−2). Our data set reveals a hyper‐dominance of eight species that together that comprise 80% of all captures: Platyrrhinus lineatus (2.3%), Molossus molossus (2.8%), Artibeus obscurus (3.4%), Artibeus planirostris (5.2%), Artibeus fimbriatus (7%), Sturnira lilium (14.5%), Carollia perspicillata (15.6%), and Artibeus lituratus (29.2%).
Iterative hard thresholding for model selection in genome‐wide association studies
Authors: Keys Kevin L. , Chen Gary K. , Lange Kenneth 
Published: September 2017

ABSTRACTA genome‐wide association study (GWAS) correlates marker and trait variation in a study sample. Each subject is genotyped at a multitude of SNPs (single nucleotide polymorphisms) spanning the genome. Here, we assume that subjects are randomly collected unrelateds and that trait values are normally distributed or can be transformed to normality. Over the past decade, geneticists have been remarkably successful in applying GWAS analysis to hundreds of traits. The massive amount of data produced in these studies present unique computational challenges. Penalized regression with the ℓ1penalty (LASSO) or minimax concave penalty (MCP) penalties is capable of selecting a handful of associated SNPs from millions of potential SNPs. Unfortunately, model selection can be corrupted by false positives and false negatives, obscuring the genetic underpinning of a trait. Here, we compare LASSO and MCP penalized regression to iterative hard thresholding (IHT). On GWAS regression data, IHT is better at model selection and comparable in speed to both methods of penalized regression. This conclusion holds for both simulated and real GWAS data. IHT fosters parallelization and scales well in problems with large numbers of causal markers. Our parallel implementation of IHT accommodates SNP genotype compression and exploits multiple CPU cores and graphics processing units (GPUs). This allows statistical geneticists to leverage commodity desktop computers in GWAS analysis and to avoid supercomputing.Availability: Source code is freely available athttps://github.com/klkeys/IHT.jl.
On the integrity of functional brain networks in schizophrenia, Parkinson's disease, and advanced age: Evidence from connectivity‐based single‐subject classification
Authors: Pläschke Rachel N. , Cieslik Edna C. , Müller Veronika I. , Hoffstaedter Felix , Plachti Anna , Varikuti Deepthi P. , Goosses Mareike , Latz Anne , Caspers Svenja , Jockwitz Christiane , Moebus Susanne , Gruber Oliver , Eickhoff Claudia R. , Reetz Kathrin , Heller Julia , Südmeyer Martin , Mathys Christian , Caspers Julian , Grefkes Christian , Kalenscher Tobias , Langner Robert , Eickhoff Simon B. 
Published: September 2017

AbstractPrevious whole‐brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD), or normal aging equally translate into high classification accuracies for these conditions. We compared classification performance between pre‐defined networks for each group and, for any given network, between groups. Separate support vector machine classifications of 86 SCZ patients, 80 PD patients, and 95 older adults relative to their matched healthy/young controls, respectively, were performed on functional connectivity in 12 task‐based, meta‐analytically defined networks using 25 replications of a nested 10‐fold cross‐validation scheme. Classification performance of the various networks clearly differed between conditions, as those networks that best classified one disease were usually non‐informative for the other. For SCZ, but not PD, emotion‐processing, empathy, and cognitive action control networks distinguished patients most accurately from controls. For PD, but not SCZ, networks subserving autobiographical or semantic memory, motor execution, and theory‐of‐mind cognition yielded the best classifications. In contrast, young–old classification was excellent based on all networks and outperformed both clinical classifications. Our pattern‐classification approach captured associations between clinical and developmental conditions and functional network integrity with a higher level of specificity than did previous whole‐brain analyses. Taken together, our results support resting‐state connectivity as a marker of functional dysregulation in specific networks known to be affected by SCZ and PD, while suggesting that aging affects network integrity in a more global way. Hum Brain Mapp 38:5845–5858, 2017. © 2017 Wiley Periodicals, Inc.
Decision of surgical approach for advanced gallbladder adenocarcinoma based on a Bayesian network
Authors: Cong Long‐Long , Cai Zhi‐Qiang , Guo Peng , Chen Chen , Liu De‐Chun , Li Wen‐Zhi , Wang Lin , Zhao Yaling , Si Shu‐Bin , Geng Zhi‐Min 
Published: September 2017

Background and ObjectivesTo determine whether radical resection can benefit patients with advanced gallbladder adenocarcinoma using a Bayesian network (BN) with clinical data.MethodsIn total, 362 patients who had undergone surgical treatment of gallbladder adenocarcinoma at a tertiary institute were evaluated to establish two BN models using a tree‐augmented naïve Bayes algorithm. We then chose 250 patients with T3‐4N0‐2M0 stage gallbladder adenocarcinoma to test the posterior probability after the surgical type was taken into account.ResultsIn total, 170 patients (≤7 months) and 137 patients (>7 months) were correctly classified in the median survival time model (accuracy, 84.81%), and 204 patients (≤12 months), 15 patients (12‐36 months), 17 patients (36‐60 months), and 34 patients (>60 months) were correctly classified in the 1‐, 3‐, and 5‐year survival model (accuracy, 74.59%), respectively. Every posterior probability in the two models upregulated the ratio of the longer survival time and suggested a better prognosis for gallbladder adenocarcinoma that can be improved by R0 resection.ConclusionsThese BN models indicate that stages T4 and N2 gallbladder adenocarcinoma are not contraindications for surgery and that R0 resection can improve survival in patients with advanced gallbladder adenocarcinoma.
S100A16 is a prognostic marker for colorectal cancer
Authors: Sun Xu , Wang Teng , Zhang Chun , Ning Kuan , Guan Zhang‐Rui , Chen Shu‐Xian , Hong Ting‐Ting , Hua Dong 
Published: September 2017

BackgroundS100 is a superfamily of calcium‐binding proteins that regulate multiple biological processes and are involved in many diseases. S100A16 has recently been identified to be involved in several cancers such as bladder cancer, lung cancer, and oral squamous cell carcinoma. However, the role of S100A16 expression in the colorectal cancer (CRC) has not been investigated.MethodsS100A16 protein expression was detected by immunohistochemistry in 296 cases of CRC. Kaplan‐Meier survival analysis and Cox regression analysis were performed to evaluate the prognostic significance of S100A16.ResultThe results showed that the overall survival (OS) of patients with low membrane S100A16 expression was significantly shorter than patients with high expression (P < 0.05). Chi‐square analysis showed that S100A16 expression had a positive correlation with tumor grade (P = 0.02). Multivariate analysis identified membrane S100A16 expression as an independent prognostic marker for OS in CRC patients. (P < 0.05). Univariate analysis showed no significant association between cytoplasmic/nuclear S100A16 expression and OS.ConclusionMembrane S100A16 is associated with the prognosis of CRC patients, indicating that S100A16 may be a potential prognostic biomarker and therapeutic target for CRC.
Recent progress of task‐specific ionic liquids in chiral resolution and extraction of biological samples and metal ions
Authors: Wu Datong , Cai Pengfei , Zhao Xiaoyong , Kong Yong , Pan Yuanjiang 
Published: September 2017

AbstractIonic liquids have been functionalized for modern applications. The functional ionic liquids are also called task‐specific ionic liquids. Various task‐specific ionic liquids with certain groups have been constructed and exploited widely in the field of separation. To take advantage of their properties in separation science, task‐specific ionic liquids are generally used in techniques such as liquid–liquid extraction, solid‐phase extraction, gas chromatography, high‐performance liquid chromatography, and capillary electrophoresis. This review mainly covers original research papers published in the last five years, and we will focus on task‐specific ionic liquids as the chiral selectors in chiral resolution and as extractant or sensor for biological samples and metal ion purification.
We've failed: Pirate black open access is trumping green and gold and we must change our approach
Authors: Green Toby 
Published: September 2017

Key points
Sci‐Hub has made nearly all articles freely available using a black open access model, leaving green and gold models in its dust.
Why, after 20 years of effort, have green and gold open access not achieved more? Do we need ‘tae think again’?
If human nature is to postpone change for as long as possible, are green and gold open access fundamentally flawed?
Open and closed publishing models depend on bundle pricing paid by one stakeholder, the others getting a free ride. Is unbundling a fairer model?
If publishers changed course and unbundled their product, would this open a legal, fairer route to 100% open access and see off the pirates?
An instrumented timed up and go in facioscapulohumeral muscular dystrophy
Authors: Huisinga Jessie , Bruetsch Adam , Mccalley Ayla , Currence Melissa , Herbelin Laura , Jawdat Omar , Pasnoor Mamatha , Dimachkie Mazen , Barohn Richard , Statland Jeffrey 
Published: September 2017

ABSTRACTIntroduction: Instrumenting timed functional motor tasks may reveal a continuum of motor disability that predicts future motor dysfunction. Methods: We performed a prospective study of the instrumented timed up and go (iTUG) test in genetically confirmed facioscapulohumeral muscular dystrophy (FSHD) participants using a commercially available system of wireless motion sensors. Patients returned within 2 weeks to determine test–retest reliability. Gait parameters in FSHD participants were compared with a normative database, FSHD clinical severity score, manual muscle testing, and patient‐reported functional disability. Results: Gait parameters in FSHD participants were significantly (P < 0.05) altered compared with normative values, and reliability was excellent (intraclass correlation coefficient 0.84–0.99). Stride velocity and trunk sagittal range of motion had moderate to strong correlations to other FSHD disease measures. Discussion: The iTUG was reliable, abnormal in FSHD, and could distinguish between participants with differing disease severities. Instrumenting timed functional tasks may prove to be useful in FSHD clinical trials. Muscle Nerve 57: 503–506, 2018
Adolescence transitional care in neurogenic detrusor overactivity and the use of OnabotulinumtoxinA: A clinical algorithm from an Italian consensus statement
Authors: Palleschi Giovanni , Mosiello Giovanni , Iacovelli Valerio , Musco Stefania , Del Popolo Giulio , Giannantoni Antonella , Carbone Antonio , Carone Roberto , Tubaro Andrea , De Gennaro Mario , Marte Antonio , Finazzi Agrò Enrico 
Published: September 2017

AimsOnabotulinumtoxinA (onaBNTa) for treating neurogenic detrusor overactivity (NDO) is widely used after its regulatory approval in adults. Although the administration of onaBNTa is still considered off‐label in children, data have already been reported on its efficacy and safety. Nowadays, there is a lack of standardized protocols for treatment of NDO with onaBNTa in adolescent patients in their transition from the childhood to the adult age. With the aim to address this issue a consensus panel was obtained.MethodsA panel of leading urologists and urogynaecologists skilled in functional urology, neuro‐urology, urogynaecology, and pediatric urology participated in a consensus‐forming project using a Delphi method to reach national consensus on NDO—onaBNTa treatment in adolescence transitional care.ResultsIn total, 11 experts participated. All panelists participated in the four phases of the consensus process. Consensus was reached if ≥70% of the experts agreed on recommendations. To facilitate a common understanding among all experts, a face‐to‐face consensus meeting was held in Rome in march 2015 and then with a follow‐up teleconference in march 2017. By the end of the Delphi process, formal consensus was achieved for 100% of the items and an algorithm was then developed.ConclusionsThis manuscript represents the first report on the onaBNTa in adolescents. Young adults should be treated as a distinct sub‐population in policy, planning, programming, and research, as strongly sustained by national public health care. This consensus and the algorithm could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.
Diabetes affects everything: Type 2 diabetes self‐management among Spanish‐speaking hispanic immigrants
Authors: Smith‐Miller Cheryl A. , Berry Diane C. , Miller Cass T. 
Published: September 2017

ABSTRACTThis article is a report of qualitative findings of a mixed‐methods study of the relationships among knowledge, self‐efficacy, health promoting behaviors, and type 2 diabetes mellitus (T2DM) self‐management among limited‐english‐proficient recent Hispanic immigrants, a population with increased incidence of T2DM and barriers to successful T2DM management. Semi‐structured interviews were conducted with 30 participants, and physiological and demographic data also were collected. The participants generally attributed developing the disease to strong emotions and viewed T2DM as a serious disease. Although a majority understood the importance of exercise and diet in T2DM self‐management, other aspects such as medication adherence were not well‐understood. Obstacles to effective T2DM self‐management were negative interactions and communications with health care providers and other personnel, cultural stigma related to the disease, financial constraints, immigration status, and the complexity of the disease. Suggested interventions to improve the care and self‐management of this at‐risk population are discussed.
PDBsum: Structural summaries of PDB entries
Authors: Laskowski Roman A. , Jabłońska Jagoda , Pravda Lukáš , Vařeková Radka Svobodová , Thornton Janet M. 
Published: September 2017

AbstractPDBsum is a web server providing structural information on the entries in the Protein Data Bank (PDB). The analyses are primarily image‐based and include protein secondary structure, protein‐ligand and protein‐DNA interactions, PROCHECK analyses of structural quality, and many others. The 3D structures can be viewed interactively in RasMol, PyMOL, and a JavaScript viewer called 3Dmol.js. Users can upload their own PDB files and obtain a set of password‐protected PDBsum analyses for each. The server is freely accessible to all at: http://www.ebi.ac.uk/pdbsum.