bluuebunny/crossref_metadata_2025_split huggingface dataset:
NF-κB at the Crossroads of Normal Mammary Gland Biology and the Pathogenesis and Prevention of BRCA1-Mutated Breast Cancer
Authors: Sau Andrea , Cabrita Miguel A. , Pratt M.A. Christine 
Published: November 2017

Abstract
Recent studies have shown that progesterone receptor (PR)–expressing cells respond to progesterone in part through the induction of the receptor activator of NF-κB ligand (RANKL), which acts in a paracrine manner to induce expansion of a RANK-expressing luminal progenitor cell population. The RANK+ population in human breast tissue from carriers of BRCA1 mutations (BRCA1mut/+) as well as the luminal progenitor population in Brca1-deficient mouse mammary glands is abnormally amplified. Remarkably, mouse Brca1+/− and human BRCA1mut/+ progenitor cells are able to form colonies in vitro in the absence of progesterone, demonstrating a hormone-independent proliferative capacity. Our research has demonstrated that proliferation in BRCA1-deficient cells results in a DNA damage response (DDR) that activates a persistent NF-κB signal, which supplants progesterone/RANKL signaling for an extended time period. Thus, the transcriptional targets normally activated by RANKL that promote a proliferative response in luminal progenitors can contribute to the susceptibility of mammary epithelial cells to BRCA1-mutated breast cancers as a consequence of DDR-induced NF-κB. Together, these latest findings mark substantial progress in uncovering the mechanisms driving high rates of breast tumorigenesis in BRCA1 mutation carriers and ultimately reveal possibilities for nonsurgical prevention strategies. Cancer Prev Res; 11(2); 69–80. ©2017 AACR.
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Authors: Ogawa Aiko , Satoh Toru , Fukuda Tetsuya , Sugimura Koichiro , Fukumoto Yoshihiro , Emoto Noriaki , Yamada Norikazu , Yao Atsushi , Ando Motomi , Ogino Hitoshi , Tanabe Nobuhiro , Tsujino Ichizo , Hanaoka Masayuki , Minatoya Kenji , Ito Hiroshi , Matsubara Hiromi 
Published: November 2017

Background—
Balloon pulmonary angioplasty (BPA) is an alternative therapy for patients with chronic thromboembolic pulmonary hypertension who are ineligible for pulmonary endarterectomy—the standard therapy. Currently, most reported results of BPA are from relatively small cohorts treated at single centers. The present study evaluated the safety and efficacy of BPA for chronic thromboembolic pulmonary hypertension based on a multicenter registry.

Methods and Results—
A total of 308 patients (62 men and 246 women; mean age, 61 years) underwent 1408 procedures at 7 institutions in Japan. Data were retrospectively reviewed to evaluate clinical outcome and complications. Hemodynamics were significantly improved in 249 patients in whom BPA was terminated, most often because of improvement in mean pulmonary arterial pressure or symptomatic improvement after 1154 procedures. In 196 patients who underwent follow-up right heart catheterization, improvement of hemodynamic parameters was maintained. Mean pulmonary arterial pressure decreased from 43.2±11.0 to 24.3±6.4 mm Hg after final BPA and 22.5±5.4 mm Hg at follow-up, with significant reduction of concomitant use of pulmonary hypertension-targeted therapy and oxygen supplementation. Complications occurred in 511 (36.3%), including pulmonary injury (17.8%), hemoptysis (14.0%), and pulmonary artery perforation (2.9%). Twelve patients (3.9%) died during follow-up, including 8 patients who died within 30 days after BPA. The leading causes of death were right heart failure, multiorgan failure, and sepsis. Overall survival was 96.8% (95% confidence interval, 93.7%–98.4%) at 1 and 2 years and 94.5% (95% confidence interval, 89.3%–97.3%) at 3 years, respectively, after the initial BPA procedure for all 308 patients.

Conclusions—
This multicenter registry suggested improved hemodynamic results after BPA. Complication rates were high, but overall survival was comparable with pulmonary endarterectomy. BPA may be an important therapeutic option in patients with chronic thromboembolic pulmonary hypertension.
Counterclockwise and Clockwise Rotation of QRS Transitional Zone: Prospective Correlates of Change and Time‐Varying Associations With Cardiovascular Outcomes
Authors: Patel Siddharth , Kwak Lucia , Agarwal Sunil K. , Tereshchenko Larisa G. , Coresh Josef , Soliman Elsayed Z. , Matsushita Kunihiro 
Published: November 2017

Background

A few studies have recently reported clockwise and counterclockwise rotations of
QRS
transition zone as predictors of mortality. However, their prospective correlates and associations with individual cardiovascular disease (
CVD
) outcomes are yet to be investigated.

Methods and Results

Among 13 567
ARIC
(Atherosclerosis Risk in Communities) study participants aged 45 to 64 years, we studied key correlates of changes in the status of clockwise and counterclockwise rotation over time as well as the association of rotation status with incidence of coronary heart disease (2408 events), heart failure (2196 events), stroke (991 events), composite
CVD
(4124 events), 898
CVD
deaths, and 3469 non‐
CVD
deaths over 23 years of follow‐up. At baseline, counterclockwise rotation was most prevalent (52.9%), followed by no (40.5%) and clockwise (6.6%) rotation. Of patients with no rotation, 57.9% experienced counterclockwise or clockwise rotation during follow‐up, with diabetes mellitus and black race significantly predicting clockwise and counterclockwise conversion, respectively. Clockwise rotation was significantly associated with higher risk of heart failure (hazard ratio, 1.20; 95% confidence interval [CI], 1.02–1.41) and non‐
CVD
death (hazard ratio, 1.28; 95% CI, 1.12–1.46) after adjusting for potential confounders including other ECG parameters. On the contrary, counterclockwise rotation was significantly related to lower risk of composite
CVD
(hazard ratio, 0.93; 95% CI, 0.87–0.99]),
CVD
mortality (hazard ratio, 0.76; 95% CI, 0.65–0.88), and non‐
CVD
deaths (hazard ratio, 0.92; 95% CI, 0.85–0.99 [borderline significance with heart failure]).

Conclusions

Counterclockwise rotation, the most prevalent
QRS
transition zone pattern, demonstrated the lowest risk of
CVD
and mortality, whereas clockwise rotation was associated with the highest risk of heart failure and non‐
CVD
mortality. These results have implications on how to interpret
QRS
transition zone rotation when ECG was recorded.
Whole body perfusion strategy for aortic arch repair under moderate hypothermia
Authors: Tarola Christopher L. , Losenno Katie L. , Gelinas Jill J. , Jones Philip M. , Fernandes Philip , Fox Stephanie A. , Kiaii Bob , Chu Michael W.A. 
Published: November 2017

Introduction: Aortic arch reconstruction under moderate hypothermia is commonly performed with antegrade cerebral perfusion (ACP) for brain protection; however, hypothermia alone is often solely relied upon for visceral and lower body protection. We investigated whether the addition of simultaneous lower body perfusion to ACP (whole body perfusion - WBP) may ameliorate the metabolic derangements of moderate hypothermic circulatory arrest (MHCA). Methods: Between 2008 and 2014, 106 consecutive patients underwent elective or emergent aortic arch surgery with MHCA, with either ACP only (44 patients, 66±12 years, 30% female) or WBP (62 patients, 61±15 years, 31% female). Primary outcomes included 30-day/in-hospital mortality, intensive care unit (ICU) and hospital lengths of stay (LOS) and specific parameters of metabolic recovery. Results: There were no significant differences between the groups in 30-day/in-hospital mortality (ACP: 3 (6.8%), WBP: 2 (3.2%); p=0.65), stroke (ACP: 1 (2.3%), WBP: 1 (1.6%); p=1.0) or renal failure (ACP: 2 (4.5%), WBP: 1 (1.5%); p=0.57). In the WBP group, we identified a significant reduction in lactate level at ICU admission (ACP 5.5 vs. WBP 3.5 mmol/L; p=0.002), time to lactate normalization (p=0.014) and median ICU length-of-stay (ACP 3 vs. WBP 1 days; p=0.049). There was no difference in post-operative creatinine (ACP: 104, WBP: 107 μmol/L; p=0.66). After multivariable regression adjustment, perfusion strategy no longer remained an independent predictor of ICU discharge time (p=0.09), however, cardiopulmonary bypass time (p=0.02), age (p=0.012) and emergent surgery (p=0.02) were. Conclusions: A WBP strategy during aortic arch reconstruction with MHCA may be associated with more rapid normalization of metabolic parameters and reduced ICU length of stay compared to using ACP alone. Further evaluation with a randomized trial is warranted.
АНАЛИЗ РАСПРОСТРАНЕННОСТИ ФАКТОРОВ РИСКА СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ СРЕДИ МУЖЧИН МЕДИЦИНСКИХ РАБОТНИКОВ КРУПНОЙ КЛИНИЧЕСКОЙ БОЛЬНИЦЫ ГОРОДА КРАСНОЯРСКА
Authors: Derevyannich Evgeny Valeryevich , Balashova Natalia Arlenovna , Yaskevich Roman Anatolyevich , Moskalenko Olga Leonidovna 
Published: November 2017

Цель. Изучение распространенности факторов риска (ФР) сердечно-сосудистых заболеваний (CCЗ) среди мужчин медицинских работников крупной клинической больницы г. Красноярска.Материалы и методы. Обследовано 251 мужчин медицинских работников в возрасте от 20 до 77 лет. Обследование включало анкетирование, клинические, инструментальные, функциональные и лабораторные методы исследования.Результаты. По данным проведенного исследования, распространенность ФР ССЗ отмечается также часто, как и в других исследованиях, среди медицинских работников, проведенных в различных регионах РФ. Среди обследованных мужчин медицинских работников у 19% было диагностировано ожирение, отягощенная наследственность составила 49,0%, доля медицинских работников, ежедневно потребляющих табак составила 48,8%, с той или иной периодичностью употребляют алкогольные напитки 61,8% обследуемых. Согласно результатов исследования, среди мужчин медицинских работников, выявлен высокий риск сердечно-­сосудистых осложнений, особенно это касается показателей очень высокого риска, при котором возможность развития осложнений в ближайшие десять лет составляет более 30%.Заключение. Несмотря на достаточно высокую профессиональную информированность, выявлена близкая к популяционной, высокая распространенность основных факторов риска ССЗ среди мужчин медицинских работников крупной клинической больницы города Красноярска. Мужчины, медицинские работники, подвержены курению, злоупотреблению алкоголем, многие имеют избыточную массу тела и ожирение. Полученные данные о распространённости ФР среди мужчин медицинских работников определяют необходимость активного выявления среди них ФР ССЗ и повышения внимания к этой категории лиц в ходе диспансеризации.
ОПЫТ ЭКСПЛУАТАЦИИ АЛЮМОХРОМОВЫХ КАТАЛИЗАТОРОВ В ПРОЦЕССЕ ДЕГИДРИРОВАНИЯ 2-МЕТИЛБУТАНА
Authors: Kasyanova L. Z. , Karimov O. K. , Karimov E. K. , Arifulina D. R. , Akhmetzyanova A. R. 
Published: November 2017

В статье приводятся результаты исследования изменения характеристик алюмохромового катализатора дегидрирования парафиновых углеводородов ИМ-2201С. На примере промышленного процесса дегидрирования 2-метилбутана показано изменение каталитических свойств за 12 лет эксплуатации катализатора. Приводятся рекомендации по снижению расходных норм сырья.
Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
Authors: Lacinová Ľ. 
Published: November 2017

Abstract
Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.
Language choice, identity and social distance: Ethnic minority students in Vietnam
Authors: Nguyen Trang Thi Thuy , Hamid M. Obaidul 
Published: November 2017

AbstractDrawing on concepts such as convergence, divergence and maintenance associated with Communication Accommodation Theory, this article examines a group of Vietnamese ethnic minority students’ language choice in relation to their identity and social distance between them and their interlocutors. Our analysis suggests that the strategies of accommodation deployed by individuals can be related to common values/tendencies that are maintained by the groups and communities to which they belong, raising issues about structural influence on individual language choice and agency. We observe that enhancing the ethnolinguistic vitality of the home and the community in which senior members hold the key to language maintenance should be considered vital in reducing the new in-group distance created by young members. Moreover, multilingual policies which enable flexible attainment goals for all languages may provide a way forward for equity and reduction of social distance between different ethnic groups in society.
Bodenverdichtung im Dauergrünland und ihre Auswirkung auf die Grünlandvegetation
Authors: Bohner Andreas , Gehmacher Philipp , Bodner Gernot , Strauss Peter 
Published: November 2017

Zusammenfassung
Die Bodenverdichtung ist ein aktuelles Problem der intensiven Grünlandwirtschaft. Daher wurden in einem repräsentativen österreichischen Grünlandgebiet an 22 unterschiedlichen Standorten die Lagerungsdichte (LD), der Eindringwiderstand (EW) und das Porenvolumen von typischen Dauergrünlandböden (Braunerde, Pseudogley, Gley) bis zu einer Bodentiefe von 30 cm bestimmt, um die bodenverdichtende Wirkung einer intensiven Grünlandbewirtschaftung beurteilen zu können. Außerdem wurde geprüft, ob zwischen den bodenphysikalischen Parametern und dem Auftreten von Bodenverdichtungszeigern im Pflanzenbestand ein Zusammenhang existiert. Der Verdichtungszustand von Dauergrünlandböden hängt von den Bodeneigenschaften (Humusgehalt, Bodenart), der Bewirtschaftungsform und der Nutzungsintensität ab. Die Verdichtungsempfindlichkeit sinkt mit steigendem Humus- und Tongehalt im Boden. Bei hoher Nutzungsintensität sind die Dauergrünlandböden mäßig überverdichtet. Die stärkste Bodenverdichtung entsteht infolge intensiver Beweidung mit Rindern. Durch Viehtritt wird der Boden insbesondere bis in 15 cm Tiefe verdichtet. Häufiges Befahren mit Grünlandmaschinen bewirkt eine Verdichtung zumindest bis 25 cm Bodentiefe. Die Mähweiden nehmen hinsichtlich Bodenverdichtung eine Mittelstellung zwischen Wiesen und Weiden ein. Die Gefahr einer ertragsmindernden Schadverdichtung steigt in Lehmböden beträchtlich, wenn innerhalb der oberen Bodenschicht (0-20 cm) eine Verdichtungszone mit einer LD über 1,40 g/cm3 oder einem EW größer als 2,00 MPa auftritt. Die Bodenverdichtung wird im Dauergrünland durch Zeigerpflanzen zuverlässig indiziert. Ranunculus repens ist ein besonders sensitiver Bioindikator für Bodenverdichtung.
Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease
Authors: Kyriazoglou Anastasios , Dimitriadis Ioannis , Bamias Aristotelis 
Published: November 2017

AbstractThe treatment paradigm in renal cell carcinoma (RCC) is rapidly changing. The incidental finding of small renal tumours combined with the development of novel therapeutic agents targeting the vascular endothelial growth factor (VEGF) or the mammalian target of rapamycin (mTOR) pathways or inhibiting the interaction of the programmed death 1 (PD 1) receptor with its ligand have dramatically improved the prognosis of patients suffering from this malignancy. At the same time, the availability of multiple effective options with similar indications complicates the development and applicability of guidelines in this disease. We conducted a systematic review of the existing guidelines. Our study revealed areas of agreement as well as of discrepancies amongst the published scientific papers included. By critically evaluating these areas, we developed a therapeutic algorithm for RCC. We suggest that this methodology can define the practices of wide applicability and areas of future research.
The impact of precision of tree position measurements and different plot designs on the estimates of tree level production and diversity parameters
Authors: Merganič Ján , Merganičová Katarína , Scheer Ľubomír , Mistrík Milan , Costantini Federico , Výbošťok Jozef 
Published: November 2017

AbstractSample plots are basic units of statistical forest inventories. The choice of their shape and size, and sampling methods have changed over time due to economic constraints, efficiency and changes in human demands on data about forests. In the presented study we analysed the impact of three different sampling units: fixed-area plots, fixed-different-area plots, and nested concentric plots, on the estimates of tree level production and diversity parameters. These sampling units were measured during the regional inventory at the University Forest Enterprise of Technical University Zvolen, Slovakia, which was repeated four times (1986, 1992, 1998, 2012). Within each inventory plot, all positions of trees were repeatedly and independently measured three times (1986, 1998, 2012) by different operators using different tools. From these data we quantified the error of tree position resulting from human and technological factors and analysed its impact on the estimates of tree level diversity and production parameters. The selected parameters were: number of trees, stand basal area, standing volume per hectare, number of tree species and number of vertical tree layers. The results indicate that the plot design primarily affects ecological characteristics of forests. Fixed-area plots seem to be the most suitable sampling unit from the point of multi-criteria evaluation of forest status and forest change.
Long-term transformation of submontane spruce-beech forests in the Jizerské hory Mts.: dynamics of natural regeneration
Authors: Slanař Jiří , Vacek Zdeněk , Vacek Stanislav , Bulušek Daniel , Cukor Jan , Štefančík Igor , Bílek Lukáš , Král Jan 
Published: November 2017

AbstractThe paper deals with development of the natural regeneration of even-aged spruce-beech forests during their transformation to uneven-aged stands with diversified structure at the Jedlový důl area in the Protected Landscape Area Jizerské hory Mts., Czech Republic. Shelterwood management system and free felling policy based on selection principles has been applied there since 1979 with the support of admixed tree species of the natural species composition, especially silver fir (Abies alba Mill.). The research was focuses on structure and development of natural regeneration with the emphasis on ungulate damage and interaction with tree layer from 1979 to 2015. In the course of 36 years, the regeneration structure was diversified towards the close-to-nature tree species composition, spatial and age structure. The number of regeneration recruits increased in average from 941 to 41,669 ind ha-1. During this period share of European beech (Fagus sylvatica L.) significantly (p < 0.01) increased (by 53.6%), while the share of Norway spruce (Picea abies [L.] Karst.) decreased (by 51.5%), such as damage caused by ungulate (by 61.4%) with the highest loses on sycamore maple (Acer pseudoplatanus L.), rowan (Sorbus aucuparia L.) and silver fir. Moreover, the parent trees had a significant negative influence on natural regeneration at smaller spacing (within a 1 - 5 m radius from the stem). Both, regeneration potential and effective role of the tree layer during the forest transformation has been confirmed as important prerequisites for ongoing forest transformation.
An inverse problem for the KdV equation with Neumann boundary measured data
Authors: Kumarasamy Sakthivel , Hasanov Alemdar 
Published: November 2017

Abstract
In this paper, we consider an inverse coefficient problem for the linearized Korteweg–de Vries (KdV) equation

u
t

+

u

x
⁢
x
⁢
x

+

(

c
⁢

(
x
)

⁢
u

)

x

=
0

{u_{t}+u_{xxx}+(c(x)u)_{x}=0}

, with homogeneous boundary conditions

u
⁢

(
0
,
t
)

=

u
⁢

(
1
,
t
)

=

u
x

⁢

(
1
,
t
)

=
0

{u(0,t)=u(1,t)=u_{x}(1,t)=0}

, when the Neumann data

g
⁢

(
t
)

:=

u
x

⁢

(
0
,
t
)

{g(t):=u_{x}(0,t)}

,

t
∈

(
0
,
T
)

{t\in(0,T)}

, is given as an available measured output at the boundary

x
=
0

{x=0}

.
The inverse problem is formulated as a minimum problem for the regularized Tikhonov functional

𝒥
α

⁢

(
c
)

=

1
2

⁢

∥

u
x

⁢

(
0
,
⋅
;
c
)

-
g

∥

L
2

⁢

(
0
,
T
)

2

+

α
2

⁢

∥

c
′

∥

L
2

⁢

(
0
,
1
)

2

{\mathcal{J}_{\alpha}(c)=\frac{1}{2}\|u_{x}(0,\cdot\,;c)-g\|^{2}_{L^{2}(0,T)}+%
\frac{\alpha}{2}\|c^{\prime}\|^{2}_{L^{2}(0,1)}}

with Sobolev norm.
Based on a priori estimates for the weak and regular weak solutions of the direct and adjoint problems, it is proved that the input-output operator is compact, which shows the ill-posedness of the inverse problem.
Then Fréchet differentiability of the Tikhonov functional and Lipschitz continuity of the Fréchet gradient are proved.
It is shown that the last result allows us to use an important advantage of gradient methods when the functional is from the class

C

1
,
1

⁢

(
ℳ
)

{C^{1,1}(\mathcal{M})}

.
In the final part, an existence of a solution of the minimum problem for the regularized Tikhonov functional

𝒥
α

⁢

(
c
)

{\mathcal{J}_{\alpha}(c)}

is proved.
Studies on rheological, structural, optical, electrical and surface properties of LiMn2O4thin films by varied spin rates
Authors: Balakrishnan T. , Subramanian N. Sankara , Kathalingam A. 
Published: November 2017

AbstractLiMn2O4thin films prepared by cost-effective spin coating method using optimized coating conditions are reported. Spin rate was varied and spin rate dependent properties were studied. Prepared films were characterized for their structural, morphological and optical properties. X-ray diffraction study of LiMn2O4thin films confirmed the cubic spinel structure with the preferred orientation along (1 1 1) plane. Optical absorption studies showed band gap energy of 3.02 eV for the grown LiMn2O4films. FT-IR bands assigned to asymmetric stretching modes of MnO6group were located around 623 cm-1and 514 cm-1for the LiMn2O4thin films. The weak band observed at 437 cm-1was attributed to the LiO4tetrahedra. The films showed high conductivity value 0.79 S/cm indicating the generation of effective network of the film for enhanced charge transport. AFM micrographs of the LiMn2O4films deposited at 3000 rpm and 3500 rpm showed uniform distribution of fine grains throughout the surface without any dark pits, pinholes and cracks.
The Role of Semantics in Spanish Word Recognition: an Insight from Lexical Decision and Categorization Tasks
Authors: Izura Cristina , Hernández-Muñoz Natividad 
Published: November 2017

AbstractThis study examines the factors affecting word recognition in a language with a consistent system to map letters into sounds; Spanish. The influence of semantics on the recognition of words in languages with inconsistent mappings, such as English, is well documented. Not much is known for other languages. A lexical decision task and two category verification tasks with varying levels of semantic complexity were used. In contrast to English, none of the semantic variables entered into the analyses had a significant impact on lexical decision latencies or errors. Imageability showed an influence on responses to both category verification tasks while the effect of connectivity was marginally significant in the category verification task with the greatest semantic complexity. Results indicate that word recognition decisions can be made without the involvement of central components of the semantic system. The role of semantics in word recognition in languages with consistent spelling systems will be discussed.