bluuebunny/crossref_metadata_2025_split huggingface dataset:
The knowledge, training, and willingness of first year students in Xuzhou, China to perform bystander cardiopulmonary resuscitation: a cross-sectional study
Authors: Qin Zhaohui , Zheng Shuyao , Liu Chenxu , Ren Yuxin , Wang Ran , Zhang Sitian , Gu Xiao , Li Yichen , Yan Xianliang , Xu Tie 
Published: September 2024

BackgroundBystander Cardiopulmonary Resuscitation (CPR) can significantly improve the rate of return of spontaneous circulation in patients with cardiac arrest. Since first year students with no specific academic background are energetic and quick to learn, many Chinese schools offer first-aid training course including CPR to them before they start school. However, data on CPR knowledge, training, and willingness among first year students are lacking in most regions of China, which makes the effectiveness of CPR training unknown.ObjectivesTo evaluate first year students’ knowledge level, training experience and rescue willingness for CPR of first year students in Xuzhou, and to analyze the influencing factors of CPR knowledge level and rescue willingness of first year students in Xuzhou.DesignA cross-sectional study.ParticipationsA total of 9,887 first year students from three universities in Xuzhou city were selected by multi-stage random cluster sampling method.MethodsA self-designed five-part structured questionnaire was used to investigate the knowledge, training and willingness of CPR among first year students. Independent sample t-test, χ2-test and Logistic regression were used for data analysis.ResultsThe average score of CPR knowledge was 2.44 (±1.60), 99.13% of the respondents were willing to participate in CPR training, and 66.25% had received CPR training. Respondents with rural household registration, relatives who had suffered from serious diseases, relatives engaged in the medical profession, good self-rated quality of life, CPR training, and willing to CPR training had higher CPR knowledge levels. 76.77% of the respondents were willing to perform bystander CPR. Women, those who had received CPR training, and those who were willing to receive CPR training were more willing to help patients with sudden cardiac arrest. Lack of first aid knowledge and skills (82.61%) was the biggest obstacle hindering respondents from performing rescue.ConclusionMost of the first year students of Xuzhou University in China have CPR training experience and have a strong willingness to train. Most are willing to perform bystander CPR, but have a low knowledge level. Colleges and universities can adopt diversified training methods, make plans for regular CPR retraining and other strategies to improve the quality and effect of CPR training for college students.
Remote coaching for supporting the implementation of treatment for depression in primary care in Madhya Pradesh, India: protocol for a cluster randomized controlled trial
Authors: Bondre Ameya P. , Singh Abhishek , Tugnawat Deepak , Chandke Dinesh , Khan Azaz , Shrivastava Ritu , Lu Chunling , Ramaswamy Rohit , Patel Vikram , Bhan Anant , Naslund John A. 
Published: September 2024

BackgroundUpwards of ninety percent of individuals living with depression in India do not have access to evidence-based treatments, especially in rural areas. Integrating these treatments into primary care is essential for bridging this care gap. This trial aims to evaluate whether a remote coaching implementation support strategy, referred to as Enhanced Implementation Support, is superior to routine support, referred to as Routine Implementation Support, in supporting the delivery of collaborative depression care in rural primary care centers.MethodsEmploying a cluster-randomized hybrid type-III implementation trial design, 14 primary care facilities in Sehore district, Madhya Pradesh, will implement a collaborative depression care package based on the WHO's mhGAP program. Facilities will be randomized to either Enhanced Implementation Support or the Routine Implementation Support control condition. Enhanced Implementation Support consists of remote coaching and technical assistance, supplemented with in-person visits, and guided by the Plan-Do-Study-Act implementation cycles. The primary implementation outcome is the proportion of outpatients screened for depression by facility staff, with secondary outcomes including the proportions of outpatients who screen positive for depression, are referred to the medical officer, and initiate treatment. Secondary patient outcomes include proportion of patients who achieve reduction in depression symptom severity at 3-month follow up. Acceptability, feasibility, and fidelity of the depression care package will be assessed through routine observations collected during field visits, facility audits, and qualitative exit interviews with facility staff. Costs of delivering the Enhanced Implementation Support strategy will also be estimated.DiscussionThis trial can inform efforts to integrate depression care in rural primary care facilities in a low-resource setting, and illuminate whether external coaching support is superior relative to existing implementation support for achieving these goals.
Trial RegistrationNCT05264792.
Multiparameter analysis of Diuron and its metabolites (DCA and DCPMU) in different stages of zebrafish (Danio rerio) development
Authors: Peixoto Paloma Vitória Lima , Sales Bianca Camargo Penteado , Aggio Luiza , Viriato Cristina , Pereira Lilian Cristina 
Published: September 2024

IntroductionDiuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a prominent herbicide in Brazilian agriculture, particularly in sugarcane farming. This herbicide persists in the environment and is transformed into potentially toxic metabolites, such as 3,4-dichloroaniline (DCA) and 3-(3,4-dichlorophenyl)-1-methylurea (DCPMU), raising concerns that encompass environmental contamination and One Health, which unites environmental and human health. Zebrafish are an appropriate experimental model to evaluate toxicity: they metabolically and genetically resemble humans and can be applied in ecotoxicology.MethodsIn this study, we have employed multiparameter evaluation to characterize the toxicity of environmentally relevant concentrations (0.5–100 μM) of Diuron, DCA, or DCPMU in Brazil, a developing country. In the early stages of zebrafish development, we performed the fish embryo toxicity test according to the guidelines established in OECD Protocol No. 236, extended to 144 h post fertilization (hpf). We also investigated the oxygen consumption rate in zebrafish embryos at 24 hpf, evaluated the acetylcholinesterase (AChE) enzymatic activity in zebrafish larvae at 96 hpf, and used the Comet Assay to assess DNA fragmentation in zebrafish larvae at 96 hpf. We subjected adult zebrafish to acute exposure for 96 h in accordance with OECD protocol no. 203 for the Acute Toxicity Test in Fish. Following this exposure, we analyzed mutagenicity by using the micronucleus test, which was complemented by quantification of nuclear anomalies (NA) in erythrocytes and further confirmed by histopathological investigations.Results and discussionExposure to any of the tested Diuron concentrations damaged DNA, and NA became significant beyond 10 μM Diuron. At 10 μM, DCA altered AChE activity, suggesting neuromuscular toxicity. Between 0.5 and 5 μM, DCA was potentially genotoxic, and 5–10 μM DCA induced nuclear pleomorphism. At all the tested concentrations, DCPMU damaged DNA, and NA emerged between 1 and 10 μM DCPMU. Adult zebrafish exposed to any of the tested Diuron, DCA, or DCPMU concentrations for 96 h did not exhibit significant histopathological alterations. Erythrocyte morphology analysis did not reveal mutagenicity. Although we observed non-mutagenic genotoxicity, chromosomal instability is of concern. The findings of this study contribute to our understanding of how Diuron and its metabolites affect zebrafish and highlights the need for multiparametric assessment to elucidate how herbicides and their metabolites impact the environment and human health. This endeavor informs regulatory measures for safely using Diuron and similar herbicides and reveals substantial implications for developing nations grappling with escalating water contamination due to pesticide use.
Potential financial loss and risk factors for hamstring muscle injuries in elite male Brazilian soccer players: a season-long prospective cohort pilot study
Authors: Oliveira-Júnior Otaviano , Gabbett Tim J. , Bittencourt Natalia F. N. , Quintão Roberto C. , Reis Guilherme F. , Claudino João G. , Lasmar Rodrigo C. P. , Leopoldino Amanda A. O. 
Published: September 2024

PurposeThe aim of this pilot study was to analyze the potential financial loss and a range of potential risk factors for hamstring muscle injuries in elite Brazilian soccer.MethodsThirty-four male players (age: 25 ± 6 years; stature: 180 ± 8 cm; body mass: 78 ± 9 kg; minutes played in matches: 2243 ± 1423 min) from an elite professional soccer club were monitored during a 12-month season. Muscle injury was identified by magnetic resonance imaging and the severity was defined according to the number of days away: minimal (1–3 days), mild (4–7 days), moderate (8–28 days), severe (&gt;28 days). Potential financial loss due to the team's under achievements was determined. Dorsiflexion range of motion, eccentric knee flexor strength and isokinetic tests were performed during the pre-season. Association between dependent variables and the occurrence of injury was evaluated.ResultsNine hamstring muscle injuries with moderate severity were found in 8 athletes. Recovery time was 22 days off the field on average. Potential financial loss was $-43.2 million USD and earnings on merit money was 21%. Previous injury, increased flexor deficit 60° /sec and increased flexor fatigue index 300°/sec were all associated with a greater chance of hamstring muscle injury. Ankle dorsiflexion range of motion was significantly lower in the injured group (35.6 ± 3° vs. 39.1 ± 4.9°; p = 0.017, effect size = −0.74).ConclusionHigh financial burden was found in elite Brazilian soccer during one full season. Injured athletes had high hamstring fatigue index, knee flexor strength deficit, ankle range of motion restriction and previous hamstring muscle injury when compared to non-injured athletes. Therefore, preventive approaches in professional soccer players with previous hamstring injuries should be a priority.
Feature importance for estimating rating of perceived exertion from cardiorespiratory signals using machine learning
Authors: Cheng Runbei , Haste Phoebe , Levens Elyse , Bergmann Jeroen 
Published: September 2024

IntroductionThe purpose of this study is to investigate the importance of respiratory features, relative to heart rate (HR), when estimating rating of perceived exertion (RPE) using machine learning models.MethodsA total of 20 participants aged 18 to 43 were recruited to carry out Yo-Yo level-1 intermittent recovery tests, while wearing a COSMED K5 portable metabolic machine. RPE information was collected throughout the Yo-Yo test for each participant. Three regression models (linear, random forest, and a multi-layer perceptron) were tested with 8 training features (HR, minute ventilation (VE), respiratory frequency (Rf), volume of oxygen consumed (VO2), age, gender, weight, and height).ResultsUsing a leave-one-subject-out cross validation, the random forest model was found to be the most accurate, with a root mean square error of 1.849, and a mean absolute error of 1.461 ± 1.133. Feature importance was estimated via permutation feature importance, and VE was found to be the most important for all three models followed by HR.DiscussionFuture works that aim to estimate RPE using wearable sensors should therefore consider using a combination of cardiovascular and respiratory data.
Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies
Authors: Almeida Cristina Ferreira , Palmeira Andreia , Valente Maria João , Correia-da-Silva Georgina , Vinggaard Anne Marie , Sousa Maria Emília , Teixeira Natércia , Amaral Cristina 
Published: September 2024

Background: Breast cancer therapy has been facing remarkable changes. Classic treatments are now combined with other therapies to improve efficacy and surpass resistance. Indeed, the emergence of resistance demands the development of novel therapeutic approaches. Due to key estrogen signaling, estrogen receptor-positive (ER+) breast cancer treatment has always been focused on aromatase inhibition and ER modulation. Lately, the effects of phytocannabinoids, mainly Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have been evaluated in different cancers, including breast. However, Cannabis sativa contains more than 120 phytocannabinoids less researched and understood. Methods: Here, we evaluated, both in silico and in vitro, the ability of 129 phytocannabinoids to modulate important molecular targets in ER+ breast cancer: aromatase, ER, and androgen receptor (AR). Results: In silico results suggested that some cannabinoids may inhibit aromatase and act as ERα antagonists. Nine selected cannabinoids showed, in vitro, potential to act either as ER antagonists with inverse agonist properties, or as ER agonists. Moreover, these cannabinoids were considered as weak aromatase inhibitors and AR antagonists with inverse agonist action. Conclusions: Overall, we present, for the first time, a comprehensive analysis of the actions of the phytocannabinoids in targets of ER+ breast tumors, pointing out their therapeutic potential in cancer and in other diseases.
Adoption of clinical pharmacist roles in primary care: longitudinal evidence from English general practice
Authors: Anderson Michael , Francetic Igor 
Published: September 2024

BackgroundOver the past decade, the number of clinical pharmacists working within multidisciplinary teams in English general practices has expanded.AimTo examine changes in quality of prescribing after the adoption of clinical pharmacist roles in English general practices.Design and settingLongitudinal cohort study in English general practice.MethodTwo-way fixed-effects regression was used to compare differences in prescribing indicators in general practices with and without pharmacists between September 2015 and December 2019.ResultsBetween September 2015 and December 2019, the proportion of practices employing a clinical pharmacist increased from 236/7623 (3.1%) to 1402/6836 (20.5%). Clinical pharmacist implementation resulted in statistically significant reductions in total costs of medicines per 1000 patients (−0.85%, 95% confidence interval [CI] = −1.50% to −0.21%), the total number of opioid prescriptions per 1000 patients (−1.06%, 95% CI = −1.82% to −0.29%), and the average daily quantity of anxiolytics per 1000 patients (−1.26%, 95% CI = −2.40% to −0.12%). Clinical pharmacist implementation also resulted in reductions in the total number of prescriptions per 1000 patients (−0.58%, 95% CI = −1.30% to 0.13%) and the total number of antibiotic prescriptions per 1000 patients (−0.51%, 95% CI = −1.30% to 0.27%) that trended towards statistical significance. There were no statistically significant differences in the share of broad-spectrum versus narrow-spectrum antibiotics (0.02%, 95% CI = −0.07% to 0.11%) and the oral morphine equivalence of high-dose opioids (>120 mg per 24 h) per 1000 patients (1.19%, 95% CI = −0.46% to 2.85%).ConclusionThis analysis is limited by practice-level data but supports the hypothesis that clinical pharmacist implementation results in improvements in prescribing quality.
Assessing of the relationship between the internal costs of information and communication technologies and the social and economic indicators of the development of the regions of Russia
Authors: Аний Л.Л. 
Published: September 2024

Работа посвящена анализу структуры затрат на информационно-коммуникационные технологии и оценке факторов, влияющих на их формирование в регионах РФ. Важнейшими потребителями и производителями ИКТ продукции являются высокотехнологические компании, которые постепенно меняют свою финансовую политику, что приводит к формированию и перераспределению затрат. В исследовании показано, что большая часть затрат осуществляется за счет собственных средств предприятий и организаций, причем предприятия сокращают объем использования внешних средств, все больше рассчитывая на свои собственные средства. Для оценки факторов, влияющих на формирование затрат на ИКТ в регионах РФ, рассчитан индекс, показывающий соотношение внутренних и внешних затрат. Регионы проранжированы по значению этого индекса, выделено три группы и произведен регрессионный анализ по данным за 2019 год. Установлено, что наиболее тесная взаимосвязь внутренних затрат на ИКТ в регионах России наблюдается со следующими показателями: ВРП, численность персонала, занятого научными исследованиями, и используемые передовые производственные технологии.The work is devoted to the analysis of the structure of costs for information and communication technologies and the assessment of factors affecting their formation in the regions of the Russian Federation. The most important consumers and manufacturers of ICT products are high-tech companies, which are gradually changing their financial policies, which leads to the formation and redistribution of costs. The study shows that most of the costs are borne by the own funds of enterprises and organizations, and enterprises are reducing the use of external funds, increasingly counting on their own funds. To assess the factors affecting the formation of ICT costs in the regions of the Russian Federation, an index was calculated showing the ratio of internal and external costs. Regions are ranked by the value of this index, three groups were identified and regression analysis was performed according to data for 2019. It was found that the closest relationship between the internal costs of ICT in the regions of Russia is observed with the following indicators: GRP, the number of personnel engaged in scientific research and the advanced production technologies used.
Literature as a Remedy for the (De)sensitization of the Contemporary Child. Attempt of Practical Approach Using the Theme of War
Authors: Ungeheuer-Gołąb Alicja Anna 
Published: September 2024

The text is theoretical in its nature and deals with the subject of the influence of literature on the child in early school age in terms of affecting the sensitivity of the recipient. The author considers the phenomenon of (de)sensitization as a process that would help the modern child to accept taboo phenomena on the example of the subject of war. The article refers to the theory of the Highly Sensitive Child and the “bitter-sweet” impact of art, recalling the works of Elaine Aron and Susan Cain. It was emphasized that the child’s hypersensitivity to certain images or sounds is related not only to natural stages of development, but also, or perhaps mainly, to individual predispositions to sensitivity to stimuli. The considerations included in the article also refer to war-themed texts for children published in Poland. The researcher provides a list of reading materials that may be interesting for contemporary child readers, but are not part of the school canon. The text is supplemented by a practical example of working with Liliana Bardijewska’s work entitled Karim’s Cat and Pictures with the use of a board game as a form of work with text at the level of grades I–III of primary school.
Monte Carlo simulation study on BaMO3 nanostructures in BMO-doped REBa2Cu3O
y
thin films prepared by the vapor–liquid–solid technique
Authors: Arita Tomonori , Ichino Yusuke , Horide Tomoya , Yoshida Yutaka 
Published: September 2024

Abstract
In depositing REBa2Cu3O
y
(REBCO) superconducting thin films, the vapor–liquid–solid (VLS) technique offers advantages over usual pulsed laser deposition (PLD) for achieving high deposition rates and controlled crystal orientation. However, introducing BaMO3 (BMO) additions into VLS-REBCO thin films to enhance critical current density in magnetic fields can lead to distinct nanostructures compared to films prepared by PLD. While simulations have explored nanorod morphologies in PLD. However, a comprehensive understanding of BMO nanostructure self-organization in VLS growth remains elusive. This study presents a novel simulation approach that incorporates the liquid phase as droplets and motion of them within the VLS process. This model successfully reproduces experimental observed BMO nanostructures in VLS growth, providing valuable insights and a practical guideline for tailoring BMO nanostructures using the VLS technique.
OPTIMIZING ENGLISH WRITING WITH AI: UNLOCK THE POWER OF QUILLBOT
Authors: Safrida Galuh , Puspitasari Desi 
Published: September 2024

AbstractThis research aims to determine the role of QuillBot as one of Artificial Intelligence (AI) in enhancing students’ writing skills. Artificial Intelligence (AI) is an advanced technology that can make a person's work easier. AI has a significant impact in various fields, such as education. Therefore, AI technology can assist students in completing their assignments. One such application is QuillBot, which aids students in improving their English writing. This research employed qualitative research using a questionnaire distributed via Google Forms. The findings indicate that Quillbot is beneficial for the students. It improves their paraphrasing skills, grammar, and vocabulary. This article is essential because readers can learn about the usefulness of AI applications, especially QuillBot, in writing English. It is also hoped that this research can encourage the adoption of similar technologies to support the learning process in various fields.
Keywords: English Writing, AI, Paraphrasing tool, QuillBot
Bingo Game in Improving Dental Health Knowledge in Elementary School
Authors: Octavianita Dahlia , Purnama Tedi , Emini Emini , Nurilawaty Vitri 
Published: September 2024

Background: Effective education outreach is influenced by the media and methods used. Educating elementary school students requires methods that can capture their attention, such as using gaming media. With the advancement of technology, there are many interactive games that can be developed for use as educational tools. One interactive gaming medium that can be used for education outreach in this context is bingo. Modifying bingo into an educational medium can cultivate teamwork among students, enhance student engagement in learning, and create a more vibrant learning atmosphere. Objective: To analyze the level of dental health knowledge of 5th grade students at SDN Beji 2 Depok before and after education using the bingo game. Method: This research employs a quasi-experimental method with a one-group pretest-posttest design. It was conducted at SDN Beji 2 Depok, utilizing total sampling, involving 47 students. The independent variable is the bingo game, and the dependent variable is the level of dental health knowledge among students. The instruments used include a questionnaire and the bingo game media. Data analysis is conducted using the Wilcoxon signed-rank test. Results: This study shows the average value of dental health knowledge before playing with bingo games is 65.53 and after playing with bingo games is 93.62, with Wilcoxon test results of p<0.001. Conclusion: Bingo game is effective in improving dental health knowledge among elementary school students.