bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sound localization with microsecond precision in mammals: what is it we do not understand?
Authors: Leibold C. , Grothe B. 
Published: April 2017

Abstract
The Jeffress model for the computation and encoding of interaural time differences (ITDs) is one of the most widely known theoretical models of a neuronal microcircuit. In archosaurs (birds and reptiles), several features envisioned by Jeffress in 1948 seem to be implemented, like a topographic map of space and axonal delay lines. In mammals, however, most of the model predictions could not be verified or have been disproved. This led to an ongoing competition of alternative models and hypothesis, which is not settled by far. Particularly the role of the feed-forward inhibitory inputs to the binaural coincidence detector neurons in the medial superior olive (MSO) remains a matter of debate. In this paper, we review the present state of the field and indicate what in our opinion are the most important gaps in understanding of the mammalian circuitry. Approaching these issues requires integrating all levels of neuroscience from cellular biophysics to behavior and even evolution.
Evoking plasticity through sensory stimulation: Implications for learning and rehabilitation
Authors: Dinse Hubert R. , Tegenthoff Martin 
Published: April 2017

Abstract
The gold standard for improving sensory, motor and or cognitive abilities is longterm training and practicing. Recent work, however, suggests that intensive training may not be necessary. Improved performance can be effectively acquired by a complementary approach in which the learning occurs in response to mere exposure to repetitive sensory stimulation. Such training-independent sensory learning (TISL), which has been intensively studied in the somatosensory system, induces in humans lasting changes in perception and neural processing, without any explicit task training. It has been suggested that the effectiveness of this form of learning stems from the fact that the stimulation protocols used are optimized to alter synaptic transmission and efficacy. TISL provides novel ways to investigate in humans the relation between learning processes and underlying cellular and molecular mechanisms, and to explore alternative strategies for intervention and therapy.
TASK, TREK & Co.: a mutable potassium channel family for diverse tasks in the brain
Authors: Ehling P. , Bittner Stefan , Meuth Sven G. , Budde Thomas 
Published: April 2017

Abstract
Discovered during the 1990s and in the beginning regarded as passive membrane pores, the family of two-pore domain potassium (K2P)-channels initially received only little attention. Today the view on this channel family comprising 15 ubiquitously expressed members in mammals has greatly changed. K2P-channels carry potassium outward current that counterbalances membrane depolarization and stabilizes the resting membrane potential. Thereby they are important regulators for the excitability and the firing behaviour especially in neurons. The long list of modulating mechanisms underlines the channels’ relevance. K2P-channels in the thalamus contribute to the regulation of the sleep-wake cycle. They also mediate the effect of volatile anaesthetics by supporting the thalamic activity mode that is also typical for sleep. This review summarizes our knowledge about K2P-channel physiology in the brain, provides an idea of the role of these channels in neurological diseases and lists open questions as well as technical challenges in K2P-channel research.
Neuron–glia synapses in the brain: properties, diversity and functions of NG2 glia
Authors: Steinhäuser Christian , Dietrich Dirk 
Published: April 2017

Abstract
Although NG2 glial cells represent a frequent glial cell type in the brain, characterized by expression of the NG2 proteoglycan, the functional impact of these cells is still enigmatic. A large proportion of NG2 glia are proliferatively active throughout life. These cells express a plethora of ion channels and transmitter receptors, which enable them to detect neuronal activity. Intriguingly, NG2 glial cells receive synaptic input from glutamatergic and GABAergic neurons. Since these postsynaptic glial currents are very small, their spatial and temporal integration might play an important role. In white matter, most NG2 glial cells differentiate into oligodendrocytes and this process might be influenced through the activity of the aforementioned neuron-glia synapses. Increasing evidence suggests that the properties of NG2 glia vary across brain regions; however, the impact of this variability is not understood yet.
Oligodendroglial heterogeneity in time and space (NG2 glia in the CNS)
Authors: Dimou Leda , Wegner Michael 
Published: April 2017

Abstract
NG2 glia represent a neural cell population that expresses the proteoglycan NG2 and is distinct from other cell types of the central nervous system. While they generate oligodendrocytes and a subset of astrocytes during development, their progeny in the adult brain solely consists of oligodendrocytes and further NG2 glia. In the last years, it has become clear that NG2 glia represent a heterogeneous population of cells with different properties and potential. In this review we will first discuss the similarities and differences between NG2 glia of the developing and adult CNS, before we will describe the regulatory mechanisms in these cells to finally concentrate on the heterogeneity of NG2 glia under physiological and pathological conditions.
GABAA receptor subtypes: structural variety raises hope for new therapy concepts
Authors: Ernst Margot , Sieghart Werner 
Published: April 2017

Abstract
GABAA receptors are ligand-gated chloride ion channels composed of five subunits that can be opened by GABA, and modulated by multiple drugs, some of utmost clinical importance. GABAA receptors occur in the nervous system as well as in peripheral tissues where their function is largely unknown. The existence of multiple GABAA receptor subtypes with distinct subunit composition leads to multiple homologous binding sites with different degrees of similarity. Crystal structures of proteins homologous to GABAA receptors and of a GABAA receptor subtype, combined with homology modeling studies, have provided insights into the possible location of drug interaction sites. Some of these sites have been confirmed by experimental studies. For many receptor ligands, however, binding sites are not yet known. Here we will briefly review the function of distinct types of GABAA receptors and provide structural insights and experimental evidence on binding sites for ligands that could be of considerable clinical interest.
Neurobiology of food choices-between energy homeostasis, reward system, and neuroeconomics
Authors: Enax Laura , Weber Bernd 
Published: April 2017

Abstract
The rate of patients with obesity has been rapidly increasing, and this imposes a heavy economic burden on health-care systems. Food decisions, under the influence of different internal and external factors, lie at the core of this increasing health problem. Due to the biological necessity to consume sufficient amounts of food and to correctly regulate energy expenditure, there are different systems that control food intake. This article first focuses on neurobiological and hormonal foundations and explains various metabolic short- and long-term signals, such as leptin, insulin, and ghrelin. We then also present genetic factors, which directly or indirectly (via other genes or environmental influences) may affect nutritional status. Since the consumption of high-caloric foods is accompanied by dopamine release and the activation of the brain’s reward system, we will then present the interdependence of metabolic and reward systems. Last, we will present a neuroeconomic perspective that complements research on metabolic and hedonic feeding regulation.
Neuronal pathways of embarrassment
Authors: Krach Sören , Müller-Pinzler Laura , Rademacher Lena , Stolz David Sören , Paulus Frieder Michel 
Published: April 2017

Abstract
Embarrassment is a genuine human emotion that we experience while being publicly exposed in unfavorable situations. The embarrassment we feel informs us how we perform according to prevalent norms and moral values and helps to regulate the impression we make on others. One cornerstone of embarrassment is the capacity to take another’s perspective and reflect on the thoughts, feelings, and intentions of others. On the neural systems level, these processes of perspective taking are linked to neural activation in the medial prefrontal cortex and precuneus. In addition, the mishap and the expected negative evaluation induce affective arousal and activity in the anterior insula and anterior cingulate cortex. Both networks contribute to the experience of embarrassment and it is their orchestrated activity in the (para-) limbic system that accounts for this complex emotional phenomenon. From a conceptual point of view embarrassment thus presupposes the presence of others. This witnessing audience however also reacts to the mishaps of others and embarrassment may also be experienced vicariously. Here, processes of perspective taking also play an important role, while bystanders embody threats to another’s social integrity. Such interpersonal emotional phenomena gain particular relevance in the context of psychiatric disorders. Specifically, autism spectrum disorders and social anxiety disorders have core symptoms in the social domain that manifest in social interactions causing disturbances in social behavior and reduced well-being of affected individuals.
The dynamic connectome
Authors: Rumpel Simon , Triesch Jochen 
Published: April 2017

Abstract
When trying to gain intuitions about the computations implemented in neural circuits, we often use comparisons with electronic circuits. However, one fundamental difference to hard-wired electronic circuits is that the structure of neural circuits undergoes constant remodeling. Here, we discuss recent findings highlighting the dynamic nature of neural circuits and the underlying mechanisms. The dynamics of neural circuits follows rules that explain steady state statistics of synaptic properties observed at a single time point. Interestingly, these rules allow the prediction of future network states and extend the insights gained from serial sectioning electron microscopy of brain samples, which inherently provides information from only a single time point. We argue how the connectome’s dynamic nature can be reconciled with stable functioning and long-termmemory storage and how it may even benefit learning.
Linking connectomics and dynamics in the human brain
Authors: Stefanovski Leon , Ghani Amna , McIntosh Anthony Randal , Ritter Petra 
Published: April 2017

Abstract
To understand human cognition, it is essential to study the brain on multiple levels, from microscopic to macroscopic scales. Computational connectomics is a new area of neuroscience where scientists seek to combine empirical observations within a computational theory of the brain. The whole-brain network modeling and simulation platform, The Virtual Brain (TVB), is a remarkable innovation in the field of computational connectomics. By combining the connectivity of individual persons with local biologically realistic populationmodels, TVB allows simulation and prediction of the local activity of neuronal populations and the global activity unfolding along the gray matter, both of which can be linked to empiricalmeasures of electrical, hemodynamic, and structural aspects of the brain. TVB is currently used to study the structural, functional, and computational alterations in the diseased brain with reported successes in stroke and epilepsy. Subjectspecific brain models provided by TVB will result in robust and efficient personalized diagnostics, prognostics, and treatment.
Connectivity and cortical architecture
Authors: Hilgetag Claus C. , Amunts Katrin 
Published: April 2017

Abstract
Brain regions of the cerebral cortex differ in their cytoarchitecture as well as in the intrinsic connectivity within an area and the organization of macroscopic connections between different cortical areas. Nonetheless, it is not clear which rules underlie the relationship of cellular and fiber architecture, and how the characteristic cortical microand macro-connectivity are related to each other. In order to identify principles of cortical connectivity, we systematically investigate various parameters of cortical architecture and their relation to the organization of anatomical connections among cortical areas. Characteristic parameters of cortical architecture include the differential density and distribution of neurons and neuron types across the layers of cortical areas, as well as the regional distribution of different receptors of neurotransmitter systems. The cytoarchitectonic characterization of the brain is a classic approach of neuroanatomy, which recently has been supplemented by new techniques for labeling specific neural components as well as novel optical and analytical approaches. However, the systematic quantitative acquisition of architectonic and morphological parameters of the human brain has only just begun. It is a fundamental challenge to gather and quantify the extremely extensive and detailed histological data (“big data”) by novel image processing techniques. This challenge is taken up in the BigBrain project. Extensive anatomical data already exist for a number of animal models, for example, the brains of nonhuman primates, the cat or the mouse. However, for each single parameter it has to be demonstrated how far these data can be generalized across species. Previous analyses support the notion that the regionally specific cytoarchitecture of the cerebral cortex is closely linked to the existence and the laminar projection patterns of corticocortical connections. These results imply systematic relationships between the patterns of macroscopic connections among cortical areas and the regionally specific intrinsic circuitry within cortical areas. Such relations are the basis of generic models of multiscale cortical connectivity, which reflect essential anatomical and functional properties of mammalian cortical organization.
Democratisation and New Social Movements
Authors: Vodovnik Žiga 
Published: April 2017

AbstractThe article offers a reflection on the processes of democratisation in Slovenia, arguing that the new social movements were a key player in initiating and directing democratic transformation, but later came to be gradually marginalised with the consolidation of the “new” or “bourgeois” civil society. Furthermore, a new chronotope of analysis shows that the role of social movements was a necessary but not a sufficient condition for political, economic and social changes, since during the second phase of the democratisation a political detachment is already underway. The key point of contestation and discordance can be identified in their completely opposite understanding of democracy and the process of democratisation itself.
Color-Change Detection Activity in the Primate Superior Colliculus
Authors: Herman James P. , Krauzlis Richard J. 
Published: April 2017

AbstractThe primate superior colliculus (SC) is a midbrain structure that participates in the control of spatial attention. Previous studies examining the role of the SC in attention have mostly used luminance-based visual features (e.g., motion, contrast) as the stimuli and saccadic eye movements as the behavioral response, both of which are known to modulate the activity of SC neurons. To explore the limits of the SC’s involvement in the control of spatial attention, we recorded SC neuronal activity during a task using color, a visual feature dimension not traditionally associated with the SC, and required monkeys to detect threshold-level changes in the saturation of a cued stimulus by releasing a joystick during maintained fixation. Using this color-based spatial attention task, we found substantial cue-related modulation in all categories of visually responsive neurons in the intermediate layers of the SC. Notably, near-threshold changes in color saturation, both increases and decreases, evoked phasic bursts of activity with magnitudes as large as those evoked by stimulus onset. This change-detection activity had two distinctive features: activity for hits was larger than for misses, and the timing of change-detection activity accounted for 67% of joystick release latency, even though it preceded the release by at least 200 ms. We conclude that during attention tasks, SC activity denotes the behavioral relevance of the stimulus regardless of feature dimension and that phasic event-related SC activity is suitable to guide the selection of manual responses as well as saccadic eye movements.
Active Dentate Granule Cells Encode Experience to Promote the Addition of Adult-Born Hippocampal Neurons
Authors: Kirschen Gregory W. , Shen Jia , Tian Mu , Schroeder Bryce , Wang Jia , Man Guoming , Wu Song , Ge Shaoyu 
Published: April 2017

The continuous addition of new dentate granule cells (DGCs), which is regulated exquisitely by brain activity, renders the hippocampus plastic. However, how neural circuits encode experiences to affect the addition of adult-born neurons remains unknown. Here, we used endoscopic Ca2+imaging to track the real-time activity of individual DGCs in freely behaving mice. For the first time, we found that active DGCs responded to a novel experience by increasing their Ca2+event frequency preferentially. This elevated activity, which we found to be associated with object exploration, returned to baseline by 1 h in the same environment, but could be dishabituated via introduction to a novel environment. To transition seamlessly between environments, we next established a freely controllable virtual reality system for unrestrained mice. We again observed increased firing of active neurons in a virtual enriched environment. Interestingly, multiple novel virtual experiences increased the number of newborn neurons accumulatively compared with a single experience. Finally, optogenetic silencing of existing DGCs during novel environmental exploration perturbed experience-induced neuronal addition. Our study shows that the adult brain conveys novel, enriched experiences to increase the addition of adult-born hippocampal neurons by increasing the firing of active DGCs.SIGNIFICANCE STATEMENTAdult brains are constantly reshaping themselves from synapses to circuits as we encounter novel experiences from moment to moment. Importantly, this reshaping includes the addition of newborn hippocampal neurons. However, it remains largely unknown how our circuits encode experience-induced brain activity to govern the addition of new hippocampal neurons. By couplingin vivoCa2+imaging of dentate granule neurons with a novel, unrestrained virtual reality system for rodents, we discovered that a new experience increased firing of active dentate granule neurons rapidly and robustly. Exploration in multiple novel virtual environments, compared with a single environment, promoted dentate activation and enhanced the addition of new hippocampal neurons accumulatively. Finally, silencing this activation optogenetically during novel experiences perturbed experience-induced neuronal addition.
On Singing and Listening in Vaughan Williams's Early Songs
Authors: Owen Ceri 
Published: April 2017

Vaughan Williams's celebrated set of Robert Louis Stevenson settings, Songs of Travel, has lately garnered liberal scholarly attention, not least on account of the vicissitudes of its publication history. Following the cycle's premiere in 1904 it was issued in two separate books, each gathering stylistically different songs. Though a credible case for narrative coherence has been advanced in numerous accounts, the cycle's peculiar amalgamation of materials might rather be read as a signal to its projection of multiple voices, which unsettle the longstanding critical tendency to map a single protagonist through its progress. The division marked by the cycle's publication history may productively be understood to reflect a tension inherent in its aesthetic propositions, one constitutive of much of Vaughan Williams's work, which frequently mediates between the individualistic and the collective, the “artistic” and the “accessible,” and, as I suggest, the subjective voice of the individual artist in its invitation to the participation of a singing and listening community.
I propose that Vaughan Williams's early songs frequently frame the idea or demand the engagement of a listener's contribution, as particular modes of singing and listening—and singing-as-listening—are figured and invited within the music's constitution. Composed as he was searching for an individual creative voice that simultaneously sustained a nascent commitment to the social utility and intelligibility of national art music, these songs explore the possibility of achieving a self-consciously collective authorial subjectivity, often reaching toward a musical intersubjectivity wherein boundaries between self and other—and between composer, performer, and listener—are collapsed. In the recognition of such processes lies a means of examining the tendency of Vaughan Williams's work toward projecting a powerfully subjective voice that simultaneously claims identification with no single agency.
Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
Authors: Mogler Carolin , König Courtney , Wieland Matthias , Runge Anja , Besemfelder Eva , Komljenovic Dorde , Longerich Thomas , Schirmacher Peter , Augustin Hellmut G 
Published: April 2017

AbstractHepatocellular carcinoma (HCC) is among the most common and deadliest cancers worldwide. A major contributor to HCC progression is the cross talk between tumor cells and the surrounding stroma including activated hepatic stellate cells (HSC). Activation of HSC during liver damage leads to upregulation of the orphan receptor endosialin (CD248), which contributes to regulating the balance of liver regeneration and fibrosis. Based on the established role of endosialin in regulating HSC/hepatocyte cross talk, we hypothesized that HSC‐expressed endosialin might similarly affect cell proliferation during hepatocarcinogenesis. Indeed, the histological analysis of human HCC samples revealed an inverse correlation between tumor cell proliferation and stromal endosialin expression. Correspondingly, global genetic inactivation of endosialin resulted in accelerated tumor growth in an inducible mouse HCC model. A candidate‐based screen of tumor lysates and differential protein arrays of cultured HSC identified several established hepatotropic cytokines, including IGF2, RBP4, DKK1, and CCL5 as being negatively regulated by endosialin. Taken together, the experiments identify endosialin‐expressing HSC as a negative regulator of HCC progression.