bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of acute perioperative myocardial infarction on clinical outcomes after total joint replacement
Authors: Wood Thomas J. , de Beer Justin , Petruccelli Danielle , Winemaker Mitch 
Published: May 2016

Background:
Improvements in perioperative care have markedly decreased mortality after total joint replacement. Acute myocardial infarct (MI) is the most common clinically significant complication after total joint replacement (TJR) and the most common cause of 30-day mortality after TJR, which remains a concern especially in light of an older population with advanced comorbidities. In spite of this, little evidence exists in regard to its effect on TJR functional outcomes.

Methods:
To assess the potential impact, if any, of acute MI on the clinical outcomes of patients undergoing primary TJR, a matched cohort study of MI and non-MI patients was conducted to determine 1-year Oxford, Harris Hip and Knee Society score outcomes.

Results:
Of 12,739 primary TJR patients identified over a 9-year period, 0.9% (114; 95% CI, 0.75-1.1) experienced a perioperative MI. A greater proportion of MI than non-MI patients had ≥1 cardiac risk factor (P=0.001) and an American Society for Anesthesiologist (ASA) 4 status (P=0.037). Length of hospital stay was longer for MI cases (MI=11.5±9.8 vs. Non-MI=5.4±2.7, P<0.0001), with 70% requiring intensive care unit or cardiac care unit stays (P<0.0001). One-year outcome scores were similar among groups (P>0.05). One-year cardiac mortality rate was 6.1% compared to 0 non-MI deaths (P<0.0001).

Conclusions:
While functional outcomes of MI after TJR are equivalent to non-MI, 1-year mortality remains high, and targeted cardiac screening and long-term monitoring for this patient population should be implemented.
Use of Two-Piece Foot Orthoses to Adjust Lateral Inclination Angle in Medial Knee Osteoarthritis Treatment
Authors: Dessery Yoann , Belzile Étienne L. , Turmel Sylvie , Corbeil Philippe 
Published: May 2016

ABSTRACT

Introduction
Individualization of lateral inclination of foot orthoses (FO) is necessary to optimize the reduction of knee adduction moment (KAM) in medial knee osteoarthritis patients. The trial-and-error (or iterative) method is generally used for this purpose. Two kinds of orthoses can be used: several one-piece lateral FO (each with a different inclination height) for each patient or a two-piece lateral FO, that is, FO plus several laterally wedged insoles with different heights. The aim of this study was to determine whether comfort and mechanical impact on the knee and ankle are similar with the use of one-piece versus two-piece lateral FO during gait.

Material and Methods
Gait analysis was performed on 17 patients affected by medial knee osteoarthritis (grade II–III). Discomfort, frontal plane kinematics, and kinetics of the ankle and knee joints were compared in three conditions: without orthosis, with lateral customized FO, and with a combination of lateral wedge insoles and customized FO without lateral inclination. Lateral inclination was customized according to the orthotist's experience.

Results
One- and two-piece lateral customized FO had the same effect on the knee loading (p > 0.05). However, both conditions with FO led to similar significant differences in knee adduction and ankle eversion moment compared with the without-orthosis condition (p < 0.05; effect size from 0.05 to 0.40).

Conclusions
These results will be valuable for orthotists who make customized orthoses (with arch support) to reduce KAM in patients with medial knee osteoarthritis. Manufacturing two-piece orthoses is practical and economical: the customized FO can be kept and the wedge insole repeatedly replaced until the patient's pain is relieved.
Associations Between Sensorimotor Impairments in the Upper Limb at 1 Week and 6 Months After Stroke
Authors: Meyer Sarah , De Bruyn Nele , Krumlinde-Sundholm Lena , Peeters Andre , Feys Hilde , Thijs Vincent , Verheyden Geert 
Published: May 2016

Background and Purpose:
Longitudinal information regarding the prevalence of upper limb somatosensory deficits and the association with motor impairment and activity limitations is scarce. The aim of this prospective cohort study was to map the extent and distribution of somatosensory deficits, and to determine associations over time between somatosensory deficits and motor impairment and activity limitations.

Methods:
We recruited 32 participants who were assessed 4 to 7 days after stroke, and reassessed at 6 months. Somatosensory measurements included the Erasmus-modified Nottingham sensory assessment (Em-NSA), perceptual threshold of touch, thumb finding test, 2-point discrimination, and stereognosis subscale of the NSA. Evaluation of motor impairment comprised the Fugl-Meyer assessment, Motricity Index, and Action Research Arm Test. In addition, at 6 months, activity limitation was determined using the adult assisting hand assessment stroke, the ABILHAND, and hand subscale of the Stroke Impact Scale.

Results:
Somatosensory impairments were common, with 41% to 63% experiencing a deficit in one of the modalities within the first week and 3% to 50% at 6 months. In the acute phase, there were only very low associations between somatosensory and motor impairments (r = 0.03-0.20), whereas at 6 months, low to moderate associations (r = 0.32-0.69) were found for perceptual threshold of touch, thumb finding test, and stereognosis with motor impairment and activity limitations. Low associations (r = 0.01-0.29) were found between somatosensory impairments in the acute phase and motor impairments and activity limitations at 6 months.

Discussion and Conclusions
: This study showed that somatosensory impairments are common and suggests that the association with upper limb motor and functional performance increases with time after stroke.

Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A138).
A retrospective analysis of laparoscopic partial nephrectomy with segmental renal artery clamping and factors that predict postoperative renal function
Authors: Li Pu , Qin Chao , Cao Qiang , Li Jie , Lv Qiang , Meng Xiaoxin , Ju Xiaobing , Tang Lijun , Shao Pengfei 
Published: May 2016

ObjectiveTo evaluate the feasibility and efficiency of laparoscopic partial nephrectomy (LPN) with segmental renal artery clamping, and to analyse the factors affecting postoperative renal function.Patients and methodsWe conducted a retrospective analysis of 466 consecutive patients undergoing LPN using main renal artery clamping (group A, n = 152) or segmental artery clamping (group B, n = 314) between September 2007 and July 2015 in our department. Blood loss, operating time, warm ischaemia time (WIT) and renal function were compared between groups. Univariable and multivariable linear regression analyses were applied to assess the correlations of selected variables with postoperative glomerular filtration rate (GFR) reduction. Volumetric data and estimated GFR of a subset of 60 patients in group B were compared with GFR to evaluate the correlation between these functional variables and preserved renal function after LPN.ResultsThe novel technique slightly increased operating time, WIT and intra‐operative blood loss (P < 0.001), while it provided better postoperative renal function (P < 0.001) compared with the conventional technique. The blocking method and tumour characteristics were independent factors affecting GFR reduction, while WIT was not an independent factor. Correlation analysis showed that estimated GFR presented better correlation with GFR compared with kidney volume (R2 = 0.794 cf. R2 = 0.199) in predicting renal function after LPN.ConclusionsLPN with segmental artery clamping minimizes warm ischaemia injury and provides better early postoperative renal function compared with clamping the main renal artery. Kidney volume has a significantly inferior role compared with eGFR in predicting preserved renal function.
Superolateral dislocation of an intact mandibular condyle into the temporal fossa: case report and literature review
Authors: Sharma Divashree , Khasgiwala Ankit , Maheshwari Bharat , Singh Charanpreet , Shakya Neelam 
Published: May 2016

AbstractTemporomandibular joint dislocation refers to the dislodgement of mandibular condyle from the glenoid fossa. Anterior and anteromedial dislocations of the mandibular condyle are frequently reported in the literature, but superolateral dislocation is a rare presentation. This report outlines a case of superolateral dislocation of an intact mandibular condyle that occurred in conjunction with an ipsilateral mandibular parasymphysis fracture. A review of the clinical features of superolateral dislocation of the mandibular condyle and the possible techniques of its reduction ranging from the most conservative means to extensive surgical interventions is presented.
The functional morphology and role of the thelycum in insemination, and its relation to the mating system in the seagrass shrimp Ambidexter symmetricus (Decapoda: Processidae)
Authors: Rasch Jennifer A. , Bauer Raymond T. 
Published: May 2016

AbstractThere is considerable variation in structures known to function in the transfer and storage of sperm in female decapod crustaceans. The thelycum is a secondary sexual character that forms from the posterior thoracic sterna of female shrimps (especially penaeoids and sergestoids). Females in the caridean shrimp family Processidae have a thelycum‐like structure which rarely occurs in other caridean females. We tested the hypothesis that the processid thelycum serves as a spermatheca for either short‐term attachment or long‐term sperm storage. When inseminated females of the processid Ambidexter symmetricus were isolated after mating, newly spawned and then incubated embryos hatched, but in the continued absence of a male, females were unable to fertilize a subsequent spawn. Our observations on A. symmetricus show that sperm were not retained after female spawning, and thus the thelycum is not used for long‐term sperm storage as in many penaeoids. In A. symmetricus, the thelycum may serve as an external median spermatheca (seminal receptacle) for temporary attachment and storage of a sperm mass during the 2–3 h interval between mating and spawning. Observations on mating behavior support the hypothesis of a pure‐search (promiscuous) mating system in A. symmetricus, with males showing little interest before, and copulating with females only after, the female parturial molt. Mating encounters were short (<2 min). This mating system is like that of other caridean shrimps with populations structured similarly to those in A. symmetricus: a relatively high density of mobile individuals and sexual dimorphism in body size (reproductive females larger than males) but not in cheliped weaponry (similar in males and females).
A Brief Task to Assess Individual Differences in Fat Discrimination
Authors: Donovan Joseph D. , Keller Kathleen L. , Tepper Beverly J. 
Published: May 2016

AbstractFat discrimination ability varies across individuals and may be related to individual differences in fat preference and dietary behavior. The objective of this study was to develop a brief fat discrimination task using salad dressings varying in canola oil content, in a difference from control format. First, 74 subjects were identified as fat discriminators or fat non‐discriminators based on a screening task. Subjects were also classified as non‐, medium‐ or super‐tasters of the bitter compound, 6‐n‐propylthiouracil (PROP) that has previously been linked to differences in fat perception. Then, all subjects participated in a four‐sample difference from control task where they assessed the degree of difference between the test samples and a blind control. Results showed that the more sensitive groups (PROP super‐tasters and fat discriminators) were able to discern both 30 and 40% fat samples from the 55% fat blind control, but the less sensitive groups (PROP non‐ and medium tasters, and fat non‐discriminators) could only discern the 30% fat sample from the 55% fat blind control. These data suggest that the four‐sample difference‐from‐control task is a convenient method for distinguishing individuals by fat discrimination ability when they are segmented using different criteria.Practical ApplicationsThe four‐sample difference from control test for salad dressing was developed as a rapid screening tool for fat discrimination. The test was designed to fill gaps in our understanding of individual differences in fat discrimination and has practical applications for testing large numbers of respondents in consumer testing, clinical settings and genetic association studies.
Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC
Authors: Nakamura Yu , Togashi Yosuke , Nakahara Hirokazu , Tomida Shuta , Banno Eri , Terashima Masato , Hayashi Hidetoshi , de Velasco Marco A. , Sakai Kazuko , Fujita Yoshihiko , Okegawa Takatsugu , Nutahara Kikuo , Hamada Suguru , Nishio Kazuto 
Published: May 2016

Abstract
The prognosis for patients with advanced esophageal or head-and-neck squamous cell carcinoma (ESCC or HNSCC) remains poor, and the identification of additional oncogenes and their inhibitors is needed. In this study, we evaluated the sensitivities of several ESCC and HNSCC cell lines to HER inhibitors (cetuximab, erlotinib, and afatinib) in vitro and found two cell lines that were hypersensitive to afatinib. Sequence analyses for the afatinib-targeted HER family genes in the two cell lines revealed that one cell line had a previously reported activating EGFR L861Q mutation, whereas the other had an HER4 G1109C mutation of unknown function. No amplification of HER family genes was found in either of the two cell lines. The phosphorylation level of HER4 was elevated in the HER4 G1109C mutation-overexpressed HEK293 cell line, and the mutation had a transforming potential and exhibited tumorigenicity in an NIH3T3 cell line, indicating that this HER4 mutation was an activating oncogenic mutation. Afatinib dramatically reduced the phosphorylation level of EGFR or HER4 and induced apoptosis in the two cell lines. In vivo, tumor growth was also dramatically decreased by afatinib. In a database, the frequencies of HER family gene mutations in ESCC or HNSCC ranged from 0% to 5%. In particular, HER4 mutations have been found relatively frequently in HNSCC. Considering the addiction of cancer cells to activating oncogenic EGFR or HER4 mutations for proliferation, HNSCC or ESCC with such oncogenic mutations might be suitable for targeted therapy with afatinib. Mol Cancer Ther; 15(8); 1988–97. ©2016 AACR.
Exclusive Breastfeeding and the Acceptability of Donor Breast Milk for Sick, Hospitalized Infants in Kupang, Nusa Tenggara Timur, Indonesia
Authors: Murray Linda , Anggrahini Simplicia Maria , Woda Rahel Rara , Ayton Jennifer E. , Beggs Sean 
Published: May 2016

Background: The eastern Indonesian province of Nusa Tenggara Timur (NTT) has an infant mortality rate of 45 per 1000, higher than the national average (28/1000). Exclusive breastfeeding, important for improving newborn and infant survival, is encouraged among hospitalized infants in Kupang, the provincial capital of NTT. However, barriers to hospitalized infants receiving breast milk may exist. Objectives: This study explored the barriers and enablers to exclusive breastfeeding among sick and low birth weight hospitalized infants in Kupang, NTT. The attitudes and cultural beliefs of health workers and mothers regarding the use of donor breast milk (DBM) were also explored. Methods: A mixed-methods study using a convergent parallel design was conducted. A convenience sample of 74 mothers of hospitalized infants and 8 hospital staff participated in semi-structured interviews. Facility observational data were also collected. Analysis was conducted using Davis’s barrier analysis method. Results: Of the 73 questionnaires analyzed, we found that 39.7% of mothers retrospectively reported exclusively breastfeeding and 37% of mothers expressed breast milk. Expressing was associated with maternal reported exclusive breastfeeding χ2 (1, N = 73) = 6.82, P = .009. Staff supported breastfeeding for sick infants, yet mothers could only access infants during set nursery visiting hours. No mothers used DBM, and most mothers and staff found the concept distasteful. Conclusions: Increasing mothers’ opportunities for contact with infants is the first step to increasing exclusive breastfeeding rates among hospitalized infants in Kupang. This will facilitate mothers to express their breast milk, improve the acceptability of DBM, and enhance the feasibility of establishing a DBM bank.
The association between smoking and psychopathology adjusted for body mass index and gender
Authors: Dimitriadis Dimitrios G , Mamplekou Efterpi , Dimitriadis Panayiotis G , Dimitriadis George D , Papageorgiou Charalambos 
Published: May 2016

Objective: This study examined the correlation between smoking habits and psychopathology status, as well as the impact of confounders such as body mass index and gender. Method: A total of 134 non-smokers and 152 smokers were enrolled in this study. We measured psychopathology features using Symptom Checklist 90-Revised. We ran logistic regression models testing the smoking–psychopathology association, controlling for body mass index and gender. Results: Smoking was positively correlated with depression, interpersonal sensitivity, hostility, somatization, paranoid ideation and psychoticism ( P<0.05). Adjusting for body mass index and gender, the results remained largely unchanged, with a slight independent effect of body mass index. Conclusions: Our data suggest that smoking is a stronger predictor of psychopathology than body mass index and gender.
Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics
Authors: Jørgensen Peter Godsk , Jensen Magnus T , Mogelvang Rasmus , von Scholten Bernt Johan , Bech Jan , Fritz-Hansen Thomas , Galatius Søren , Biering-Sørensen Tor , Andersen Henrik U , Vilsbøll Tina , Rossing Peter , Jensen Jan S 
Published: May 2016

Objectives: We aimed to determine the prevalence of echocardiographic abnormalities and their relation to clinical characteristics and cardiac symptoms in a large, contemporary cohort of patients with type 2 diabetes. Results: A total of 1030 patients with type 2 diabetes participated. Echocardiographic abnormalities were present in 513 (49.8%) patients, mainly driven by a high prevalence of diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21.0%) and left atrial enlargement, 200 (19.6%). The prevalence increased markedly with age from 31.1% in the youngest group (<55 years) to 73.9% in the oldest group (>75 years) ( p < 0.001) and was equally distributed among the sexes ( p = 0.76). In univariate analyses, electrocardiographic abnormalities, age, body mass index, known coronary heart disease, hypertension, albuminuria, diabetes duration and creatinine were associated with abnormal echocardiography along with dyspnoea and characteristic chest pain ( p < 0.05 for all). Neither of the cardiac symptoms nor clinical characteristics had sufficient sensitivity and specificity to accurately identify patients with abnormal echocardiography. Conclusion: Echocardiographic abnormalities are very common in outpatients with type 2 diabetes, but neither cardiac symptoms nor clinical characteristics are effective to identify patients with echocardiographic abnormalities.
History of Expansion and Usage of Oil-Plants
Authors: Переверзева  , Pereverzeva E. 
Published: May 2016

The article considers the materials about the oil-plants, transplanted from the native habitat and cultivated in local soil for practical purposes.
The attention is paid to the plants that form the basis of modern oil-plant manufacture, which home country is the Old and the New World. The
article is in aid of teacher. It contains the information, which helps to form knowledge of primary schoolchildren about genesis and history of
oil-plants delivery — the source of vegetable oil. The article gives also the information about the role of oil-plants in the good balanced nutrition
of the person, especially of children and teenagers. The author considers also the questions of ecological education.
Determination of the predictive and prognostic values of polymorphism of some cell cycle genes in breast cancer
Authors: Ebeid Samia , Abd El  Moneim Nadia , Hewala Taha , Ramadan Moustafa , Shehata Gehan , Abass Heba 
Published: May 2016

Aim: To investigate the influence of the polymorphic variants of CCND1 (G870A) and p73 (G4C14- to- A4T14) on the susceptibility to breast cancer development, also, to figure out their diagnostic and prognostic roles.Subjects and Methods: Blood samples were obtained from breast cancer patients and controls. Genotyping of CCND1 and p73 genes were carried out by PCR-RFLP and PCR-CTPP; respectively.Results: In comparison with the control group, CCND1 (G870A) GA and AA genotypes frequencies were significantly higher in breast cancer patients (p=0.035 and p=0.002; respectively), whereas CCND1 (G870A) GG genotype frequency was significantly lower (p< 0.001). The CCND1 GA and AA genotypes significantly increased the risk for developing breast cancer compared with the GG genotype. The CCND1 (GA+AA) genotypes were significantly correlated with disease-free survival (DFS) of breast cancer patients. In comparison with the control group, p73 (G4C14/A4T14) GC/AT and AT/AT genotypes frequencies were significantly higher in breast cancer patients (p=0.013 and p=0.04; respectively), whereas p73 (G4C14/A4T14) GC/GC genotype frequency was significantly lower (p= 0.004). Â Compared with the GC/GC genotype, the p73 GC/AT and AT/AT genotypes significantly increased the risk for developing breast cancer. Beside being significantly correlated with DFS, p73 [(GC/AT)+ (AT/AT)] genotypes were indirectly correlated with tumor size, tumor pathological grade, patient's clinical stage, number of axillary lymph node involvement and Her2/neu expression.Conclusion: The GA and AA genotypes of CCND1 (G870A) polymorphism and the GC/AT and AT/AT genotypes of p73 (G4C14- to- A4T14) polymorphism can be used as diagnostic markers in breast cancer patients. The presence of the CCND1 (G870A) GA and AA genotypes and the GC/AT and AT/AT genotypes of p73 (G4C14- to- A4T14) polymorphism can increase the susceptibility to breast cancer incidence. Both of CCND1 (G870A) and p73 (G4C14- to- A4T14) polymorphisms can be used for prognosis of breast cancer patients.Â