bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclin-Dependent Kinase Activity is Required for Type I Interferon Production
Authors: Cingöz Oya , Goff Stephen P. 
Published: November 2017

AbstractRecognition of nucleic acids results in the production of type I interferons (IFN), which activate the JAK/STAT pathway and promote the expression of IFN-stimulated genes (ISG). In a search for modulators of this pathway, we discovered a previously unknown requirement for cyclin-dependent kinases (CDK) in the production of type I IFN following nucleic acid sensing and virus infection. Inhibition of CDK activity or knockdown of CDK levels leads to a striking block in STAT activation and ISG expression. CDKs are not required for the initial nucleic acid sensing leading to IFN-β mRNA induction, nor for the response to exogenous IFN-α/β, but are critical for IFN-β release into culture supernatants, suggesting a post-transcriptional role for CDKs in type I IFN production. In the absence of CDK activity, we demonstrate a translational block specific for IFN-β, in which IFN-β mRNA is removed from the actively translating polysomes, while the distribution of other cellular mRNAs or global translation rates are unaffected. Our findings reveal a critical role for CDKs in the translation of IFN-β.
Flight test of fault-tolerant flight control system using simple adaptive control with PID controller
Authors: Matsuki Hidenobu , Nishiyama Taishi , Omori Yuya , Suzuki Shinji , Masui Kazuya , Sato Masayuki 
Published: November 2017

Purpose
This paper aims to demonstrate the effectiveness of a fault-tolerant flight control method by using simple adaptive control (SAC) with PID controller.

Design/methodology/approach
Numerical simulations and flight tests are executed for pitch angle and roll angle control of research aircraft MuPAL-α under the following fault cases: sudden reduction in aileron effectiveness, sudden reduction in elevator effectiveness and loss of longitudinal static stability.

Findings
The simulations and flight tests reveal the effectiveness of the proposed SAC with PID controller as a fault-tolerant flight controller.

Practical implications
This research includes implications for the development of vehicles’ robustness.

Originality/value
This study proposes novel SAC-based flight controller and actually demonstrates the effectiveness by flight test.
Large eddy simulation of airfoil self-noise using OpenFOAM
Authors: Kamliya Jawahar Hasan , Lin Yujing , Savill Mark 
Published: November 2017

Purpose
The purpose of this paper is to investigate airfoil self-noise generation and propagation by using a hybrid method based on the large-eddy simulation (LES) approach and Curle’s acoustic analogy as implemented in OpenFOAM.

Design/methodology/approach
Large-eddy simulation of near-field flow over a NACA6512-63 airfoil at zero angle of attack with a boundary layer trip at Rec = 1.9 × 105 has been carried out using the OpenFOAM® computational fluid dynamics (CFD) code. Calculated flow results are compared with published experimental data. The LES includes the wind tunnel installation effects by using appropriate inflow boundary conditions obtained from a RANS κ – ω SST model computation of the whole wind tunnel domain. Far-field noise prediction was achieved by an integral method based on Curle’s acoustic analogy. The predicted sound pressure levels are validated against the experimental data at various frequency ranges.

Findings
The numerical results presented in this paper show that the flow features around a NACA6512-63 airfoil have been correctly captured in OpenFOAM LES calculations. The mean surface pressure distributions and the local pressure peaks for the step trip setup agree very well with the experimental measurements. Aeroacoustic prediction using Curle’s analogy shows an overall agreement with the experimental data. The sound pressure level-frequency spectral analysis produces very similar data at low to medium frequency, whereas the experimentally observed levels are slightly over predicted at a higher frequency range.

Practical implications
This study has achieved and evaluated an alternative aeroacoustic simulation method based on the combination of LES with a simple Smagorinsky SGS model and Curle’s analogy, as implemented in the OpenFOAM CFD code. The unsteady velocity/pressure source data produced can be used for any simpler analytically based far-field noise prediction scheme.

Originality/value
A complete integration of the LES and Curle’s acoustic analogy for aeroacoustic simulations has been achieved in OpenFOAM. The capability and accuracy of the hybrid method are fully evaluated for high-camber airfoil self-noise predictions. Wind tunnel installation effects have been incorporated properly into the LES.
An assessment of flight efficiency based on the point merge system at metroplex airports
Authors: Sahin Ozlem , Usanmaz Oznur , Turgut Enis T. 
Published: November 2017

Purpose
Metroplex is a system of two or more airports, in physical proximity, with highly interdependent arrival and departure operations. The purpose of this study is the construction of an efficient and effective air route model based on the point merge system (PMS) to reduce aircraft fuel consumption and CO2 emissions for three metroplex airports in Istanbul terminal control area (TMA).

Design/methodology/approach
A PMS arrival route model is constructed for metroplex airports. In the proposed model, two situations are taken into consideration: for delay which can be defined as flying on sequencing legs (PMSdel) and for no delay (PMSno del). An empirical model is developed using a data set including the flight data records of ten actual B737-800 domestic flights. With this empirical model, both the baseline and the PMS models (PMSdel and PMSno del) are compared in terms of fuel consumption, CO2 emissions and flight distance and time as a theoretical computation.

Findings
In the proposed PMSno del arrival route model, according to different entry points for Istanbul Ataturk International Airport (LTBA), the analyses show an average reduction of 26 per cent in flight time, 24.5 per cent in flight distance, 17 per cent in fuel burned and CO2 emissions; in addition, for Sabiha Gökcen International Airport (LTFJ) there are 34, 23 and 32 per cent average savings for flight time, flight distance and fuel burned together with CO2 emissions obtained, respectively. Even if the PMSdel model, for LTFJ except only one entry point, for LTBA except two entry points, better results are obtained than baseline.

Practical implications
The point merge model for metroplex airports in this paper can be applied by airspace designers and Air Navigation Service Providers to perform efficient and effective arrival routes.

Originality/value
In this study, a point merge model is constructed for metroplex airports. Quantitative results, using an empirical model, are achieved in terms of fuel consumption, CO2 emissions and flight distance and time at metroplex airports.
Adaptive robust control of coupled attitude and orbit for spacecraft with model uncertainties
Authors: Sun Jun , Wu Xiande , Zhang Shijie , Guo Fengzhi , Song Ting 
Published: November 2017

Purpose
The purpose of this paper is to propose an adaptive robust controller for coupled attitude and orbit control of rigid spacecraft based on dual quaternion in the presence of external disturbances and model uncertainties.

Design/methodology/approach
First, based on dual quaternion, a theoretical model of the relative motion for rigid spacecraft is introduced. Then, an adaptive robust controller which can realize coordinated control of attitude and orbit is designed in the existence of external disturbances and model uncertainties.

Findings
This paper takes advantage of the Lyapunov function which can guarantee the asymptotic stabilization of the whole system in the existence of parameters uncertainties. Simulation results show that the proposed controller is feasible and effective.

Originality/value
This paper proposes a coupled attitude and orbit adaptive robust controller based on dual quaternion. Simulation results demonstrate that the proposed controller can achieve higher control performance in the presence of parameters uncertainties.
Pilot error in process of helicopter starting
Authors: Stojiljkovic Evica , Bijelic Bojan , Grozdanovic Miroljub , Radovanovic Marko , Djokic Igor 
Published: November 2017

Purpose
The purpose of this paper is to identify potential helicopter pilots’ errors during their interaction with the flight deck in the process of starting a helicopter in night-time conditions.

Design/methodology/approach
Systematic Human Error Reduction and Prediction Approach is used for the analysis of the pilot–flight deck interaction. This methodology was used for the identification of errors for 30 pilots during a period of 10 years. In total, 55 errors were identified, and most common errors noted are: error of omission, caused by pilots’ lack of attention or longer periods of no flying, and error of wrong execution, caused by misunderstanding a situation.

Findings
Hierarchical task analysis and classification of pilot’s tasks were used for the analysis of consequences, probability of occurrence, criticality and remedial strategies for the identified pilot error.

Research limitations/implications
This paper does not give an ergonomic analysis of the flight deck, as that is not its subject. However, results of the research presented in this paper, together with results presented in references, clearly show that there are disadvantages in the ergonomic design of flight decks.

Practical implications
Based on the identified pilot errors and with respect of existing ergonomic solution, it is possible to begin with the reconstruction of flight decks.

Social implications
Higher quality of pilot–flight deck interaction must be ensured for both pilots’ and passengers’ safety, as even a slightest error can lead to catastrophic consequences.

Originality/value
The value of this paper lies in the fact that it points to the need for synergy of ergonomic design and human reliability methods.
The influence of the cutting edge shape on high performance cutting
Authors: Burek Jan , Zylka Lukasz , Plodzien Marcin , Gdula Michal , Sulkowicz Pawel 
Published: November 2017

Purpose
The purpose of this paper is to determine the influence of the shape of a cutting edge on high-performance milling high-performance cutting. The main purpose of the test was to determine the possibility of increasing the efficiency of machining AlZn5.5CuMg alloy, which is used mainly for the thin-walled structural aerospace components.

Design/methodology/approach
In all, eight cutters for machining aluminum alloys with different shape of the cutting edge (1 – continuous, 4 – interrupted, 3 – wavy) were tested. The influence of different shapes of a cutting edge on cutting force components and vibration amplitude was analyzed. Furthermore, the impact of a chip breaker on the form of a chip was determined.

Findings
The conducted test shows that using discontinuous shapes of a cutting edge has impact on the reduction of the cutting force components and, in most cases, on the increase of vibration amplitude. Moreover, using a chip breaker caused significant chip dispersion. The optimal shape of a cutting edge for cutting AlZn5.5CuMg alloy is fine wavy shape.

Practical implications
Potential practical application of the research is high-performance milling of AlZn5.5CuMg alloy, for example, production of thin-walled aerospace structural components.

Originality/value
Different shapes of a cutting edge during high-performance milling of aluminum alloy were tested. The influence of tested geometries on HPC process was determined. The most favourable shape of a cutting edge for high-performance cutting of AlZn5.5CuMg alloy was determined.
New fault-tolerant federated Kalman filters for integrated navigation
Authors: Liang Yueqian , Jia Yingmin 
Published: November 2017

Purpose
The purpose of this paper is to achieve accurate integrated navigation results for the unmanned aerial vehicle (UAV) systems even in the presence of possible navigation faults in the subsystems of the federated Kalman filter.

Design/methodology/approach
The federated Kalman filter is modified from two aspects to get accurate navigation results under abnormity. First, time-variant vector distribution coefficients trading off the navigation accuracy and the observability degree of each state component are computed to replace the traditional scalar coefficients. Second, a fault-tolerant filter is proposed as the local navigation filter.

Findings
Simulations for the navigation of a UAV system show that the proposed method can be applied for accurate navigation purpose even in the presence of subsystem navigation faults.

Originality/value
New fault-tolerant federated Kalman filters for integrated navigation are presented to achieve accurate navigation solutions.
Cumulative learning and sustained engagement in an introduction to accounting course
Authors: Aldamen Husam , Duncan Keith , Ziegelmayer Jennifer L. 
Published: November 2017

Purpose
Due to its technical focus, the introductory accounting course has a hierarchical knowledge structure that requires students to master and integrate abstract knowledge which builds on itself over time. The purpose of this paper is to explore the relationship between engagement and examination performance for students enrolled in a hierarchically structured course.

Design/methodology/approach
This research involves a retrospective study of an introduction to accounting course examining the relationship between increased engagement and examination performance. Students are provided opportunities for engagement through assigned homework and optional ungraded assignments. Performance is measured by scores on each of three examinations conducted throughout the semester.

Findings
The study finds that additional engagement in assignments has no significant impact on mid-semester examination performance; however, sustained engagement throughout the semester has a cumulative impact on final examination performance. Moreover, students that perform well on mid-semester examinations do not benefit from additional engagement, whereas students that perform poorly on the mid-semester examinations exhibit substantially higher final examination scores from sustained engagement.

Practical implications
This study illustrates the complex interplay between engagement and performance and the timing of performance gains. The implication for educators is that increased sustained engagement is likely to result in increased but delayed student performance gains in disciplines with hierarchical knowledge structures.

Originality/value
This study contributes to the literature in its examination of the timing of performance benefits gained from increased engagement in courses with a cumulative knowledge base.
Core entrepreneurial competencies of students in departments of electrical engineering and computer sciences (EECS) in universities
Authors: Chang Jen-Chia , Hsiao Yuan-Du , Chen Su-Chang , Tsung-Ta Yu 
Published: November 2017

Purpose
The purpose of this paper is to investigate entrepreneurial competencies of students in practicums within departments of electrical engineering and computer sciences (EECS) in universities of technology. In total, 71 faculty members who advised in entrepreneurial competitions in universities of technology were participants in the questionnaire survey to find the entrepreneurial competencies during practicums of the EECS students.

Design/methodology/approach
Analysis was carried out based on the literatures related to off-campus internship in universities of technology and entrepreneurship competency. Then, through the questionnaire survey, the authors can understand what the entrepreneurial abilities should have when they after off-campus internships. The entrepreneurship competency expected of off-campus internship students within EECS was analyzed to derive at the important conclusion in this study.

Findings
As the results of this study, the authors found that entrepreneurial processes, entrepreneurial traits/behaviors, communications and interpersonal skills, and digital skills are the entrepreneurial competencies that are emphasized during practicums.

Originality/value
The paper suggests that, first, the EECS students take up innovative entrepreneurship programs and take electives such as marketing management, financial management, and related business administration courses. Second, respective universities of technology and internship organizations may co-arrange the incorporation of project-based learning (PBL), PBL into the internship work content. Third, establishing a platform that bridges communication for off-campus internship students.
Specialization and commonalization in multi-branded manufacturing corporations
Authors: Karlsson Christer , Sköld Martin 
Published: November 2017

Purpose
The purpose of this paper is to identify areas and issues for management to consider in balancing specialization and commonalization in large manufacturing corporations with multiple brands from a strategic R&D and manufacturing point of view.

Design/methodology/approach
Three global manufacturing corporations from the automotive sector are used as a strategic sample composing three sequential clinical research projects. The data come from complementary data-gathering methods combining documents and interviews and workshops with top executives, project leaders, platform managers and product brand managers, thus enabling triangulation.

Findings
The study shows that managing manufacturing corporations with multiple brands is not just on a scale between full specialization and full commonalization but instead has its own logic of categorizations and portfolio formations. In order to develop the value of the brand portfolio, management must simultaneously embrace and address a number of highly integrated corporate values and highly differentiated brand company values.

Research limitations/implications
This study contributes primarily by relating economy of scale in relation to the need for differentiation of products and brands that have different values, customers and market positions. A model for balancing commonalization and specialization provides several opportunities for further research and development; however, generalizations are issue and context specific.

Practical implications
The critical issues in balancing how to deal with specialization and commonalization in a company with multiple brands are explored and summarized in a framework for the practitioner to use in analyzing a real situation.

Originality/value
Previous literature focuses on the maximization of synergies within one brand, missing the specific dynamics of large manufacturing corporations with many entities, such as individual products and brands. This paper adds knowledge regarding how to balance synergies from commonalization with important objectives to preserve the specialization and distinctiveness of each product brand.
Organizing for servitization: examining front- and back-end design configurations
Authors: Raja Jawwad Z. , Chakkol Mehmet , Johnson Mark , Beltagui Ahmad 
Published: November 2017

PurposeResearch suggests that to structure for servitization, organizations should separate their front- and back-end units by reference to high vs low contact activities. However, these prescriptions are overly simplistic and largely based on anecdotal evidence that fails to account for context. The purpose of this paper is to explore the design decisions taken by organizations in support of servitization.Design/methodology/approachA large-scale exploratory case study was conducted, consisting of embedded cases in three divisions of a UK-based, global manufacturing firm.FindingsEach division provided different combinations of offerings (i.e. product-, use- and result-oriented). The findings suggest that front-end/back-end configurations differ according to the offering and can exist concurrently within the same organization, challenging the assumption that different configurations within an organization are not possible. The findings show that underlying contextual factors, such as the complexity and temporality of the offering, as well as the power of the customer, have implications for the structuring of servitizing organizations.Research limitations/implicationsThis is a context-specific, qualitative case study conducted within a large original equipment manufacturer, yet the findings are analytically generalized.Originality/valueIn identifying the relevance of different design decisions in terms of customer contact, decoupling of activities and grouping of employees, the findings challenge the extant view that organizations simply split activities between the front- and back-end functions. The research identifies an additional design configuration – integrated project teams – involving a dominant customer dictating organizational interfaces. This research exposes the need for further investigation into how to organize for servitization in project-based contexts.
Supply chain agility, adaptability and alignment
Authors: Dubey Rameshwar , Altay Nezih , Gunasekaran Angappa , Blome Constantin , Papadopoulos Thanos , Childe Stephen J. 
Published: November 2017

PurposeThe purpose of this paper is to examine when and how organizations create agility, adaptability, and alignment as distinct supply chain properties to gain sustainable competitive advantage.Design/methodology/approachThe current study utilizes the resource-based view (RBV) under the moderating effect of top management commitment (TMC). To test the research hypotheses, the authors gathered 351 usable responses using a pre-tested questionnaire.FindingsThe statistical analyses suggest that information sharing and supply chain connectivity resources influence supply chain visibility capability, which, under the moderating effect of TMC, enhance supply chain agility, adaptability, and alignment (SCAAA).Originality/valueThe contribution lies in: providing a holistic study of the antecedents of agility, adaptability, and alignment; investigating the moderating role of TMC on SCAAA; following the RBV and addressing calls for investigating the role of resources in supply chain management, and for empirical studies with implications for supply chain design.