bluuebunny/crossref_metadata_2025_split huggingface dataset:
One year of baclofen in 100 patients with or without cirrhosis: a French real-life experience
Authors: Barrault Camille , Lison Hortensia , Roudot-Thoraval Françoise , Garioud Armand , Costentin Charlotte , Béhar Véronique , Medmoun Mourad , Pulwermacher Georges , Hagège Hervé , Cadranel Jean-François 
Published: July 2017

Background
Several studies have suggested the efficacy of baclofen in reducing alcohol consumption, leading to a temporary recommendation for use in France.

Aim
Our aim was to report our experience in using baclofen in alcohol-dependant patients with or without liver cirrhosis.

Patients and methods
Consecutive patients from two liver and alcohol units were recruited over a 3-year period and received increasing doses of baclofen associated with social, psychological, and medical care.

Results
One hundred patients were treated, of whom 65 were cirrhotic. After 1 year, 86 patients were still being followed up. At a mean dosage of 40 mg/day (extremes: 30–210), the median daily alcohol consumption reduced from 80 to 0 g/day (P<0.001). Twenty patients drank a small amount of alcohol of up to 30 g/day and 44 patients were completely abstinent. These declarative results were associated with a significant improvement in alcohol-related biological markers in this ‘low-consumption’ group of 64 patients: the median γ-glutamyl transferase decreased from 3.9 to 2.0 UNL (P<0.001), the mean aspartate transaminase decreased from 2.6 to 1.2 UNL (P<0.001), and the mean corpuscular volume decreased from 101 to 93 µm3 (P<0.001). In cirrhotic patients, bilirubinemia decreased significantly from 22 to 11 µmol/l (P=0.026), prothrombin time increased from 68 to 77% (P<0.001), and albuminemia increased from 34.1 to 37.4 g/l (P<0.001). Twenty patients reported grades 1–2 adverse events. No liver or renal function deterioration occurred in cirrhotic patients.

Conclusion
In our cohort, baclofen associated with a global care was very well tolerated even in cirrhotic patients. The marked reduction in alcohol consumption in 64 patients translated into a significant improvement in biological markers and in liver function tests. Baclofen could be very useful, especially in cases of severe alcoholic liver disease.
Potential Association of IL1B Polymorphism With Iron Deficiency Risk in Childhood Helicobacter pylori Infection
Authors: Chen Szu‐Ta , Ni Yen‐Hsuan , Liu Shing‐Hwa 
Published: July 2017

ABSTRACTObjective:Helicobacter pylori infection occurs predominantly in childhood. Host immune response gene polymorphism is reported to affect the susceptibility to H pylori infection and the outcome of H pylori‐related gastric cancer. Not all H pylori‐infected patients, however, exhibit iron deficiency (ID). The relationship between host genetic polymorphisms and ID mediated by H pylori infection is not well understood.Methods:Subjects (n = 644) from the general population of age 10 to 18 years were divided into 2 groups based on serology testing for anti‐H pylori IgG: seropositive study group; and seronegative control group. Five single nucleotide polymorphisms (SNPs) in IL1B (rs1143627 and rs16944), IL8 (rs4073), IL10 (rs1800896), and ABO (rs505922), were genotyped and the iron status of the 2 groups was compared.Results:The seroprevalence rate for H pylori was 10.7% in this study. Infected subjects were significantly older and had lower serum iron levels than uninfected subjects (P = 0.0195 and 0.0059, respectively). Multivariate analysis revealed a significantly higher frequency of the T allele of rs505922 (odds ratio [OR] = 6.128; P < 0.001) and lower frequency of the T allele of rs1143627 (OR = 0.846; P = 0.014) in seropositive subjects. Among 59 seropositive subjects, the T allele frequency of rs1143627 was significantly higher in those with ID (OR = 3.156; P = 0.043), compared with those without ID.Conclusions:ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children.
Coping Strategies Used by Breast, Prostate, and Colorectal Cancer Survivors
Authors: Lashbrook Mari P. , Valery Patricia C. , Knott Vikki , Kirshbaum Marilynne N. , Bernardes Christina M. 
Published: July 2017

Background:
Individual coping strategies are a fundamental element underpinning psychosocial distress.

Objective:
The aim of this study was to describe coping strategies and their measurement used by survivors of breast, prostate, and/or colorectal cancer after treatment.

Methods:
A search of electronic databases (PubMed, CINAHL, and PsycINFO) was conducted from January 1980 to March 2015. Data were extracted using standardized forms and included studies that explored the coping mechanisms of survivorship of breast, prostate, or colorectal cancer.

Results:
Two thousand one hundred forty-seven studies were retrieved for potential inclusion; 19 publications met the inclusion criteria and were included in the review.

Conclusions:
Breast, prostate, and colorectal cancer survivors seem to use different coping strategies that varied throughout the survivorship trajectory. Breast cancer survivors highlighted the importance of accepting their diagnosis and engaging in physical activities that provided social and emotional support. Personality seemed to have a significant effect on coping for prostate cancer survivors. Colorectal cancer survivors emphasized the importance of seeking information to master self-management and return to social activities.

Implications for Practice:
Understanding coping strategies, during the survivorship trajectories, is essential to planning contemporary care after cancer treatment. Nurses and other healthcare professionals may use this knowledge to improve quality of life and decrease distress after diagnosis.
Correlation Between Pao 2/Fio 2 and Peripheral Capillary Oxygenation/Fio 2 in Burned Children With Smoke Inhalation Injury
Authors: Cambiaso-Daniel Janos , Voigt Charles D. , Rivas Eric , Hundeshagen Gabriel , Nunez-Lopez Omar , Kamolz Lars-Peter , Sljivich Michaela , Sousse Linda E. , Herndon David N. , Suman Oscar E. , Kinsky Michael P. , Mlcak Ronald P. 
Published: July 2017

Objectives:
Determine whether the peripheral capillary oxygenation/Fio
2 ratio correlates with the Pao
2/Fio
2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/Fio
2 ratio can serve as a surrogate for the Pao
2/Fio
2 ratio for the diagnosis of acute respiratory distress syndrome.

Design:
Retrospective chart review.

Setting:
Shriners Hospitals for Children—Galveston.

Patients:
All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, Fio
2 and Pao
2 measurements.

Interventions:
None.

Measurements and Main Results:
Two hundred seventy-three patients (63% male, 8 ± 5 yr, 53% ± 24% total body surface area burns) were analyzed. Peripheral capillary oxygenation/Fio
2 ratios were divided into four subgroups based on peripheral capillary oxygenation values (≤ 100%, ≤ 98%, ≤ 95%, and ≤ 92%). Significance was accepted at r
2 greater than 0.81. The r
2 (number of matches) was 0.66 (23,072) for less than or equal to 100%, 0.87 (18,932) for less than or equal to 98%, 0.89 (7,056) for less than or equal to 95%, and 0.93 (4,229) for less than or equal to 92%. In the subgroup of patients who developed acute respiratory distress syndrome, r
2 was 0.65 (8,357) for less than or equal to 100%, 0.89 (7,578) for less than or equal to 98%, 0.89 (4,115) for less than or equal to 95%, and 0.91 (2,288) less than or equal to 92%.

Conclusions:
Pao
2/Fio
2 and peripheral capillary oxygenation/Fio
2 strongly correlate in burned children with smoke inhalation injury, with a peripheral capillary oxygenation of less than 92% providing the strongest correlation. Thus, peripheral capillary oxygenation/Fio
2 ratio may be able to serve as surrogate for Pao
2/Fio
2, especially when titrating Fio
2 to achieve a peripheral capillary oxygenation of 90–95% (i.e., in the acute respiratory distress syndrome range).
Innovative assembly strategy contributes to the understanding of evolution and conservation genetics of the critically endangeredSolenodon paradoxusfrom the island of Hispaniola
Authors: Grigorev Kirill , Kliver Sergey , Dobrynin Pavel , Komissarov Aleksey , Wolfsberger Walter , Krasheninnikova Ksenia , Afanador-Hernández Yashira M. , Paulino Liz A. , Carreras Rosanna , Rodríguez Luis E. , Núñez Adrell , Silva Filipe , Hernández-Martich J. David , Majeske Audrey J. , Antunes Agostinho , Roca Alfred L. , O’Brien Stephen J. , Martinez-Cruzado Juan Carlos , Oleksyk Taras K. 
Published: July 2017

AbstractSolenodons are insectivores living on the Caribbean islands, with few surviving related taxa. The genus occupies one of the most ancient branches among the placental mammals. The history, unique biology and adaptations of these enigmatic venomous species, can be greatly advanced given the availability of genome data, but the whole genome assembly for solenodons has never been previously performed, partially due to the difficulty in obtaining samples from the field. Island isolation has likely resulted in extreme homozygosity within the Hispaniolan solenodon (Solenodon paradoxus), thus we tested the performance of several assembly strategies for performance with genetically impoverished species’ genomes. The string-graph based assembly strategy seems a better choice compared to the conventional de Brujn graph approach, due to the high levels of homozygosity, which is often a hallmark of endemic or endangered species. A consensus reference genome was assembled from sequences of five individuals from the southern subspecies (S. p. woodi). In addition, we obtained one additional sequence of the northern subspecies (S. p. paradoxus). The resulting genome assemblies were compared to each other, and annotated for genes, with a specific emphasis on the venomous genes, repeats, variable microsatellite loci and other genomic variants. Phylogenetic positioning and selection signatures were inferred based on 4,416 single copy orthologs from 10 other mammals. Patterns of SNP variation allowed us to infer population demography, which indicated a subspecies split within the Hispaniolan solenodon at least 300 Kya.
Atrazine and amphibians: Data re-analysis and a summary of the controversy
Authors: Rohr Jason R. 
Published: July 2017

AbstractThe herbicide atrazine is one of the most commonly used, well studied, and controversial pesticides on the planet. Much of the controversy involves the effects of atrazine on wildlife, particularly amphibians and their non-infectious and infectious diseases, including diseases caused by trematode infections. Here I re-analyze data from authors that were funded by Syngenta Crop Protection, Inc., the company that produces atrazine, and show that even these authors revealed that increasing concentrations of atrazine applied to outdoor mesocosms increases the population growth rate of snails that can transmit trematode parasites to amphibians. These researchers missed this finding in their data because they never calculated population growth rates for the snail populations before they reached a carrying capacity or crashed. These results demonstrate that both Syngenta-funded and non-Syngenta-funded researchers have provided evidence that ecologically relevant concentrations of atrazine are capable of increasing snail populations. Given the controversy surrounding the effects of atrazine on amphibians, I follow this re-analysis with a timeline of some of the most salient events in the history of the atrazine-amphibian controversy.
A functional connectome phenotyping dataset including cognitive state and personality measures
Authors: Mendes Natacha , Oligschläger Sabine , Lauckner Mark E. , Golchert Johannes , Huntenburg Julia M. , Falkiewicz Marcel , Ellamil Melissa , Krause Sarah , Baczkowski Blazej M. , Cozatl Roberto , Osoianu Anastasia , Kumral Deniz , Pool Jared , Golz Laura , Dreyer Maria , Haueis Philipp , Jost Rebecca , Kramarenko Yelyzaveta , Engen Haakon , Ohrnberger Katharina , Gorgolewski Krzysztof J. , Farrugia Nicolas , Babayan Anahit , Reiter Andrea , Schaare H. Lina , Reinelt Janis , Röbbig Josefin , Uhlig Marie , Erbey Miray , Gaebler Michael , Smallwood Jonathan , Villringer Arno , Margulies Daniel S. 
Published: July 2017

AbstractThe dataset enables exploration of higher-order cognitive faculties, self-generated mental experience, and personality features in relation to the intrinsic functional architecture of the brain. We provide multimodal magnetic resonance imaging (MRI) data and a broad set of state and trait phenotypic assessments: mind-wandering, personality traits, and cognitive abilities. Specifically, 194 healthy participants (between 20 and 75 years of age) filled out 31 questionnaires, performed 7 tasks, and reported 4 probes of in-scanner mind-wandering. The scanning session included four 15.5-min resting-state functional MRI runs using a multiband EPI sequence and a high-resolution structural scan using a 3D MP2RAGE sequence. This dataset constitutes one part of the MPI-Leipzig Mind-Brain-Body database.
Thermal mismatches explain how climate change and infectious disease drove widespread amphibian extinctions
Authors: Cohen Jeremy M. , Civitello David J. , Venesky Matthew D. , McMahon Taegan A. , Rohr Jason R. 
Published: July 2017

AbstractGlobal temperatures and infectious disease outbreaks are simultaneously increasing, but linking climate change and infectious disease to modern extinctions remains difficult. Thethermal mismatch hypothesispredicts that hosts should be vulnerable to disease at temperatures where the performance gap between themselves and parasites is greatest. This framework could be used to identify species at risk from a combination of climate change and disease because it suggests that extinctions should occur when climatic conditions shift from historical baselines. We conducted laboratory experiments and analyses of recent extinctions in the amphibian genusAtelopusto show that species from the coldest environments experienced the greatest disease susceptibility and extinction risk when temperatures rapidly warmed, confirming predictions of thethermal mismatch hypothesis. Our work provides evidence that a modern mass extinction was likely driven by an interaction between climate change and infectious disease.
Isolation and characterization of BpL1, a broad acting lytic bacteriophage against Brucella
Authors: Gupta Vimlesh , Saxena Hari Mohan 
Published: July 2017

AbstractWe have isolated a new broad acting lytic brucellaphage (BpL1) from the sewage of a dairy farm. The phage lysed all the 12Brucella abortusfield isolates,B. abortusstrain 99 andBrucella melitensisbut did not lyse any of the heterologous species tested viz.Staphylococcus aureus, Pasteurella multocida, Escherichia coli,andSalmonella species. Streaking the plaques onBrucellalawn gave clear zones along the streak lines. The plaques were circular with a diameter of 0.5- 3.0 mm. At a concentration of 10−4the phage count was 4.5 × 106plaques per ml. It was a tailed phage with icosahedral head (62.2 nm in diameter and 73.71 nm in length), and the head to tail length was 229.21 nm. The phage belonged to the order Caudovirales and familySiphoviridae. It was inactivated within one hour at 55°C and within 4 hours at −20°C. Treatment at pH 2 for 4 hours and at pH 4 for 12 hours inactivated it. It was inactivated after 4 hours exposure to sunlight, and within 4 minutes by UV light. Chloroform and Sodium Dodecyl Sulfate inactivated it within 15 minutes. Lysozyme inactivated it within 1 hour whereas RNase treatment did not affect its activity.
Juxtacap Nucleotide Sequence Modulates eIF4E Binding and Translation
Authors: Keys Heather R. , Sabatini David M. 
Published: July 2017

ABSTRACTmRNA translation is an energetically costly activity required for almost all biological processes. The multiprotein complex eIF4F, which bridges the 5’ cap and the polyA tail through eIF4E and eIF4G, respectively, is necessary for efficient translation initiation of most mRNAs and is an important target of translational control. Previous work suggests that cap-proximal nucleotides can modulate eIF4E binding to mRNAs, but the effect of specific cap-proximal nucleotide sequences on eIF4E recruitment and the ultimate consequences for translation remain unknown. Using RNA Bind-n-Seq on a model 5’ UTR, we systematically identify eIF4E-intrinsic cap-proximal nucleotide binding preferences. mRNAs with highly-bound motifs are translated well in a cell-free system, whereas those with low-eIF4E-binding motifs are not. However, eIF4E juxtacap motif preferences do not dictate the ribosome occupancy of endogenous mRNAs in cells, suggesting that the effect of juxtacap sequence on eIF4E binding and translation is mRNA-context-dependent. Accordingly, a single downstream point mutation that disrupts a predicted base pair with a preferred juxtacap nucleotide increases translation. The juxtacap sequence is a previously unappreciated determinant of eIF4E recruitment to mRNAs, and we propose that differences in mRNA 5’ end accessibility defined by the juxtacap sequence are important for establishing translational efficiency.
l1kdeconv: an R package for peak calling analysis with LINCS L1000 data
Authors: Li Zhao , Li Jin , Yu Peng 
Published: July 2017

AbstractBackgroundLINCS L1000 is a high-throughput technology that allows gene expression measurement in a large number of assays. However, to fit the measurements of ~ 1000 genes in the ~ 500 color channels of LINCS L1000, every two landmark genes are designed to share a single channel. Thus, a deconvolution step is required to infer the expression values of each gene. Any errors in this step can be propagated adversely to the downstream analyses.ResultsWe presented a LINCS L1000 data peak calling R packagel1kdeconvbased on a new outlier detection method and an aggregate Gaussian mixture model (AGMM). Upon the remove of outliers and the borrowing information among similar samples,l1kdeconvshowed more stable and better performance than methods commonly used in LINCS L1000 data deconvolution.ConclusionsBased on the benchmark using both simulated data and real data, thel1kdeconvpackage achieved more stable results than the commonly used LINCS L1000 data deconvolution methods.Contactpengyu.bio@gmail.com
The genetics of the human face: identification of large effect single gene variants
Authors: Crouch Daniel J M , Winney Bruce , Koppen Willem P , Christmas William J , Hutnik Katarzyna , Day Tammy , Meena Devendra , Boumertit Abdelhamid , Hysi Pirro , Nessa Ayrun , Spector Tim D , Kittler Josef , Bodmer Walter F 
Published: July 2017

AbstractIn order to discover specific variants with relatively large effects on the human face we have devised an approach to identifying facial features with high heritability. This is based on using twin data to estimate the additive genetic value of each point on a face, as provided by a 3D camera system. In addition, we have used the ethnic difference between East Asian and European faces as a further source of face genetic variation. We use principal components analysis to provide a fine definition of the surface features of human faces around the eyes and of the profile, and chose upper and lower 10% extremes of the most heritable PCs for looking for genetic associations. Using this strategy for the analysis of 3D images of 1832 unique volunteers from the well characterised People of the British Isles study [1, 2] and 1567 unique twin images from the TwinsUK cohort (www.twinsuk.ac.uk), together with genetic data for 500,000 SNPs, we have identified three specific genetic variants with notable effects on facial profiles and eyes.Significance statementThe human face is extraordinarily variable and the extreme similarity of the faces of identical twins indicates that most of this variability is genetically determined. This level of genetic variability has probably arisen through natural selection, for example, for recognition of membership of a group or as a consequence of differential mate selection with respect to facial features. We have devised an approach to identifying specific genetic effects on particular facial features. This should enable the understanding, eventually at the molecular level, of the nature of this extraordinary genetic variability, which is such an important feature of our everyday human interactions.Author ContributionsWFB conceived the project. BW and TD organised collection of PoBI data and KH, DJMC, DM, AB and WFB assisted in data collection. TDS, PH and AN collected TwinsUK data. WPK and WJC conducted image registration analysis under supervision of JK. DJMC analysed registered image data and genetic data under supervision of WFB. WFB and DJMC wrote the manuscript, with WJC and WPK contributing additional technical material. WFB and BW supervised the project.
Changing attitudes toward genetically modified foods in urban China
Authors: Zheng Zhihao , Gao Yang , Zhang Yijing , Henneberry Shida 
Published: July 2017

Purpose
The purpose of this paper is to analyze changes in consumers’ knowledge and acceptance of genetically modified (GM) foods over the past decade and identifies the determinants in the consumer attitudes toward GM foods in urban China.

Design/methodology/approach
The data used in this study were collected from 952 urban consumers in 2013 in 15 provinces. The ordinal logit model was chosen to identify the determinants in the consumers’ subjective knowledge and acceptance of GM foods.

Findings
Results show that the consumers’ awareness of GM foods, biotech knowledge, and subjective knowledge improved significantly, while the acceptance rate toward GM foods declined considerably from 2002 to 2013. Moreover, the consumers’ subjective knowledge of GM foods had a significantly negative impact on their acceptance rate of GM foods. Finally, the media coverage with the “event of Golden rice in 2012” as a proxy helped consumers in shaping their negative perceptions toward GM foods, suggesting that the media coverage was one of major factors in leading to the low acceptance rate of GM foods in urban China.

Originality/value
The findings of previous studies conducted in the early 2000s might not reflect current Chinese consumer attitudes because the public opinion toward GM foods in modern China has considerably changed. This study thus filled in the void by updating estimates on consumer attitudes toward GM foods and by underlining the factors that have led to the changes in consumer attitudes, using a mass survey covering Chinese urban consumers in 15 provinces in 2013.