bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of two designs of implant‐supported overdentures on peri‐implant and posterior mandibular bone resorptions: a 5‐year prospective radiographic study
Authors: Elsyad Moustafa A. , Alokda Mohammed Mahmoud , Gebreel Ashraf Anwer , Hammouda Nelly Ibrahim , Habib Ahmed Ali 
Published: September 2016

AbstractObjectivesThe aim of this study was to evaluate and compare the effect of two designs of implant‐supported overdentures on peri‐implant and posterior mandibular bone resorptions after 5 years of follow‐up.Materials and methodsTwenty edentulous patients were randomly assigned into two equal groups: Group I (GI), patients received overdentures supported and retained by cantilevered bars on two canine implants and Group II (GII), patients received overdentures retained by straight bars on two canine implants and supported by two‐first molar implants. Peri‐implant vertical (VBL) and horizontal (HBLO) bone losses were assessed on periapical radiographs at the time of overdenture insertion (T0), 6 months (T6 m), 1 year (T1), 3 years (T3), and 5 years (T5) after insertion. Posterior mandibular bone resorption was evaluated using proportional measurements (posterior area index, PAI) made on panoramic radiographs at T0 and T5.ResultsGroup I recorded significant higher VBL than GII. VBL increased significantly with advance of time in both groups. Posterior implant recorded significant higher VBL than anterior implants in GII. HBLO did not differ significantly between groups or between observation times. Group I recorded significant higher PAI than GII at T5. Group, age, and initial height of the mandibular ridge were significantly correlated with PAI.ConclusionWithin the limitations of this study, regarding the small sample size, it could be concluded that overdentures retained by straight bars on two canine implants and supported by two‐first molar implants present a clinical advantage in terms of peri‐implant and posterior mandibular bone preservation compared to overdentures supported and retained by cantilevered bars on two canine implants after 5 years.
Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma
Authors: Sun Li‐Hua , Yang Fu‐Qiang , Zhang Chuan‐Bao , Wu Yi‐Ping , Liang Jing‐Shan , Jin Shuai , Wang Zheng , Wang Hong‐Jun , Bao Zhao‐Shi , Yang Zheng‐Xiang , Jiang Tao 
Published: September 2016

SummaryAimsTo explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples.MethodsRNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan–Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed.ResultsIn the discovery set, PXN overexpression was significantly associated with high‐grade glioma as well as the higher mortality in survival analysis (log‐rank test, P < 0.01). The results of the other validation datasets showed similar findings. PXN also served as an independent prognostic biomarker in glioblastoma patients. Functional assays showed that PXN contributed to glioma cell proliferation and invasion.ConclusionPXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy.
Predictors of success for double balloon‐assisted endoscopic retrograde cholangiopancreatography in patients with Roux‐en‐Y anastomosis
Authors: Liu Ken , Joshi Vikram , Saxena Payal , Kaffes Arthur J. 
Published: September 2016

Background and AimEndoscopic retrograde cholangiopancreatography (ERCP) in patients with roux‐en‐Y anastomosis (REYA) is challenging. Use of double balloon enteroscope‐assisted ERCP (DBE‐ERCP) has been successful. We aim to determine predictors of successful biliary cannulation with DBE‐ERCP in patients with REYA.MethodsWe retrospectively studied patients with REYA who had DBE‐ERCP between 2009 and 2015.Results86 DBE‐ERCP were done on 52 patients. Patients had REYA for liver transplant (n = 26), gastrojejunostomy (n = 9), previous bile duct injury (n = 9), biliary atresia (n = 2) and other (n = 6). The biliary‐enteric anastomosis was reached in 76% and cholangiogram was successful in 70%. Highest success rates were in patients with previous bile duct injury (94%) or gastrojejunostomy (89%). Post‐transplant patients had intermediate success (64%). Patients with redo surgery (46%) and childhood surgery (38%), especially Kasai procedure (20%), had low success. Patients with previous bile duct injury were more likely to succeed (94% vs 63%, P = 0.010). Those more likely to fail were patients with childhood surgery (38% vs 73%, P = 0.037), biliary atresia (20% vs 73%, P = 0.013) and second operation post‐transplant (25% vs 70%, P = 0.046).ConclusionIndication for REYA impacts on successful biliary cannulation in patients undergoing DBE‐ERCP. The procedure is most successful in non‐liver transplant adult surgery and post‐transplant patients without a second operation. It is least successful in patients with surgically corrected biliary atresia and post‐transplant patients with second operation. Alternative methods of biliary access should be considered in these patients.
Double guidewire endoscopic technique, a major evolution in endoscopic retrograde cholangiopancreatography: Results of a retrospective study with historical controls comparing two therapeutic sequential strategies
Authors: Laquiere Arthur , Desilets Etienne , Belle Arthur , Castellani Paul , Grandval Philippe , Laugier René , Penaranda Guillaume , Lecomte Laurence , Boustiere Christian 
Published: September 2016

Background and AimEndoscopic access to the common bile duct (CBD) remains difficult in 10% of cases, requiring alternative techniques .CBD access was difficult after either five unsuccessful attempts, five unintentional insertions into the pancreatic duct or >10‐min‐long unsuccessful attempts. This retrospective study with historical controls aimed to evaluate the benefit of the double guidewire (DGW) technique after failure of standard CBD cannulation.MethodsFrom January 2012 to December 2014, all patients requiring therapeutic endoscopic retrograde cholangiopancreatography (ERCP) with difficult access to CBD were included in a Studied group. This group was compared to a historical ERCP control group from January 2009 to December 2011. In the Studied group, a sequential strategy including DGW technique was done when the guidewire was unintentionally passed into the pancreatic duct. In the control group, only pre‐cut technique was used.ResultsAmong the 538 patients with naive papilla eligible for ERCP, 73 had difficult CBD access. Successful CBD access rate was higher in the Studied group: 91% (50/55) versus 67% (12/18) P = 0.0215. Complication rates were similar in both groups: 28% versus 20%, P = 0.5207. LOS was shorter in the Studied group (9.2 ± 8.5 vs 14.4 ± 7.4 days, P = 0.0028). Post‐ERCP cholangitis were lower in the Studied group: 2% (1/55) versus 22% (4/18), P = 0.0118.ConclusionAfter standard cannulation failure, DGW technique increased successful CBD access rate and decreased LOS without increasing complications.
Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm
Authors: Horiguchi Shigeru , Kato Hironari , Shiraha Hidenori , Tsutsumi Koichiro , Yamamoto Naoki , Matsumoto Kazuyuki , Tomoda Takeshi , Uchida Daisuke , Akimoto Yutaka , Mizukawa Syou , Tanaka Takehiro , Ichimura Koichi , Takaki Akinobu , Yagi Takahito , Okada Hiroyuki 
Published: September 2016

AbstractBackground and AimPathological grading is important in defining the therapeutic strategy in pancreatic neuroendocrine neoplasm (PNEN) but is difficult for unresectable cases. Endoscopic ultrasound (EUS)‐guided fine needle aspiration (FNA) is useful in the diagnosis of PNEN, but its usefulness for pathological grading is not well established. No studies have examined the diagnostic ability of dynamic computed tomography (CT) for pathological grading of PNEN. We investigated the usefulness of EUS–FNA and dynamic CT in the diagnosis and pathological grading of PNEN.MethodsIn this retrospective study, 39 PNEN patients finally diagnosed via EUS–FNA and/or surgical resection underwent dynamic CT. Pathological samples were diagnosed based on WHO2010; staging was based on the European Neuroendocrine Tumor Society classification. The proportion of the quantification value in the tumor to the pancreatic parenchyma in arterial phase was defined as the CT ratio. Immunohistochemical staining with CD31 was performed to evaluate microvessel density (MVD). We evaluated the relationship between pathological grade, CT ratio, and MVD.ResultsBy using EUS–FNA, 35 of 39 (90%) cases were diagnosed as PNEN. As for pathological grade, 15 of 35 (43%) cases could be identified correctly. CT ratio could predict pathological Grade 3 disease. The sensitivity, specificity, and diagnostic accuracy were 100%, 94%, and 95%. MVD was significantly correlated with CT ratio (r = 0.83, P < 0.0001) and pathological grade (P = 0.0074).ConclusionsComputed tomography ratio has a relationship with pathological grade in PNEN, which would help decide therapeutic strategy in unresectable cases and cases in which pathological grading is difficult.
Overall and cause‐specific mortality in Korean patients with inflammatory bowel disease: A hospital‐based cohort study
Authors: Lee Ho‐Su , Choe Jaewon , Kim Seon‐Ok , Lee Sun‐Ho , Lee Hyo Jeong , Seo Hyungil , Kim Gwang‐Un , Seo Myeongsook , Song Eun Mi , Hwang Sung Wook , Park Sang Hyoung , Yang Dong‐Hoon , Kim Kyung‐Jo , Ye Byong Duk , Byeon Jeong‐Sik , Myung Seung‐Jae , Yoon Yong Sik , Yu Chang Sik , Kim Jin‐Ho , Yang Suk‐Kyun 
Published: September 2016

AbstractBackground and AimLimited data are available regarding mortality from inflammatory bowel disease in non‐Caucasian populations. Herein, we evaluated overall and cause‐specific mortality in a hospital‐based cohort of Korean inflammatory bowel disease patients.MethodsWe determined mortality in 2414 Crohn's disease patients and 2798 ulcerative colitis patients diagnosed between 1977 and 2013. Standardized mortality ratios were calculated in several demographic and phenotypic subgroups.ResultsDuring the mean 9‐year follow up, 114 patients died: 35 with Crohn's disease and 79 with ulcerative colitis. The overall standardized mortality ratios were 1.40 (95% confidence interval: 0.97–1.94) in Crohn's disease and 0.73 (0.58–0.91) in ulcerative colitis. In Crohn's disease, female sex, age < 30 years at diagnosis, disease duration > 10 years, ileocolonic disease at diagnosis, perianal fistula, intestinal resection, and ever‐use of corticosteroids were associated with higher mortality. In ulcerative colitis, male sex, age ≥ 30 years at diagnosis, disease duration ≤ 5 years, proctitis at diagnosis, and no history of colectomy were associated with lower mortality, while primary sclerosing cholangitis was associated with higher mortality. In both Crohn's disease and ulcerative colitis, high mortality rates due to nonmalignant gastrointestinal causes (standardized mortality ratios: 4.59 and 2.32, respectively) and gastrointestinal malignancies (standardized mortality ratios: 16.59 and 3.45, respectively) were observed. Cardiovascular mortality was lower in ulcerative colitis (standardized mortality ratio: 0.47).ConclusionsThe overall mortality tended to be higher in Crohn's disease patients than in the general population; it was slightly lower in ulcerative colitis patients than in the general population.
Disease severity and erythropoiesis in chronic hepatitis C
Authors: Huang Chung‐Feng , Huang Ching‐I , Yeh Ming‐Lun , Hou Chen , Hou Nai‐Jen , Hsieh Ming‐Yen , Huang Jee‐Fu , Chen Shinn‐Cherng , Lin Zu‐Yau , Dai Chia‐Yen , Chuang Wan‐Long , Yu Ming‐Lung 
Published: September 2016

AbstractBackground/AimsThe erythropoiesis in hepatitis C virus infection is unclear. We aimed to evaluate the erythropoietic components in chronic hepatitis C (CHC) patients.MethodsThe red blood cell (RBC) components, serum erythropoietin (EPO) levels, and their relationship to clinical characteristics were evaluated between 124 age‐matched and sex‐matched healthy controls and 248 histology‐proven CHC patients.ResultsChronic hepatitis C patients had significantly higher serum levels of EPO (1.44 ± 0.36 log mIU/mL versus 1.03 ± 0.31 log mIU/mL, P < 0.0001) and lower hemoglobin (Hb) concentrations (14.6 ± 1.4 g/dL versus 15.3 ± 1.2 g/dL, P < 0.001) as compared with healthy controls. Among the CHC patients, the serum EPO level was negatively associated with the Hb concentration (β = −0.227; 95% confidence intervals [CI]: −0.09–0.027; P < 0.001) and RBC counts (β = −0.204; 95% CI: −0.245–0.061; P = 0.001) and was positively correlated with necroinflammatory activity (β = 0.201; 95% CI: 0.009–0.046; P = 0.003) and fibrosis (β = 0.143; 95% CI: 0.003–0.076; P = 0.04) of liver histopathology. For non‐cirrhotic CHC patients, the severity of liver necroinflammatory activity was positively correlated with the reticulocyte and serum EPO levels (P = 0.001 and 0.008, respectively), and negatively related to the RBC counts (P = 0.03). Using stepwise multivariate linear regression analysis, the grade of necroinflammatory activity was positive (β = 0.214; 95% CI: 0.046–0.209, P = 0.002), whereas the Hb concentration was inversely (β = −0.205; 95% CI: −0.09–0.018, P = 0.004) associated with the serum EPO levels in CHC patients.ConclusionsThe disease activity in CHC patients had a negative impact on erythropoiesis with compensatory higher but blunted EPO responses.
Cross‐linking for the analysis of α‐synuclein in the enteric nervous system
Authors: Corbillé Anne‐Gaëlle , Neunlist Michel , Derkinderen Pascal 
Published: September 2016

AbstractSince the observation that aggregated α‐synuclein, the pathological hallmark of Parkinson's disease (PD), is found in the gut in almost all patients, it has been suggested that the enteric nervous system (ENS) could be a starting point for α‐synuclein pathology. α‐synuclein has long been thought to occur as a monomer in living cells, but recent studies reported that it instead exists as a tetramer in non‐neuronal cells and in neurons. Given the possible key role of the ENS in PD pathophysiology, we undertook the current research to characterize the native state of α‐synuclein in rat primary culture of ENS and in adult human healthy ENS. Using amine‐reactive cross‐linking, we showed that, by contrast to cell lines and brain neurons, α‐synuclein exists primarily as a monomer in intact enteric neurons, suggesting that the native state of α‐synuclein is different between the ENS and the brain. Our results provide new insights into the widely discussed concepts of α‐synuclein aggregation and misfolding in PD and raise issue about the possible transmission of α‐synuclein from the ENS to the brain.
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Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson disease
Authors: Komnig Daniel , Schulz Jörg B. , Reich Arno , Falkenburger Björn H. 
Published: September 2016

AbstractThe death receptor Fas/CD95 mediates apoptotic cell death in response to external stimuli. In neurons, Fas‐induced apoptosis is prevented by Fas‐apoptotic inhibitory molecule 2 (Faim2). Mice lacking Faim2 showed increased neurodegeneration in animal models of stroke and bacterial meningitis. We therefore tested the relevance of Faim2 in a classical animal model of Parkinson disease and determined the toxicity of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) in Faim2‐deficient mice. Without MPTP treatment, there was no difference in the dopaminergic system between Faim2‐deficient mice and control mice. MPTP was applied i.p. in doses of 30 mg per kg on five consecutive days. Fourteen days after the last MPTP injection, the number of dopaminergic neurons in the lateral substantia nigra, assayed by stereological counting, was reduced by 39% in control mice and 53% in Faim2‐deficient mice. The density of dopaminergic fibers in the dorsal striatum was reduced by 36% in control mice and 69% in Faim2‐deficient mice, in the ventral striatum 44% in control mice and 76% in Faim2‐deficient mice. Fiber density recovered at 90 days after MPTP with similar density in both groups. Striatal catecholamine levels were reduced by 81–84% in both groups and recovered at 90 days. Faim2 expression was documented in mouse midbrain using quantitative reverse transcription‐PCR (qRT‐PCR) and found decreased after MPTP administration. Taken together, our findings demonstrate increased degeneration of dopaminergic neurons with Faim2 deficiency, indicating that Fas‐induced apoptosis contributes to cell death in the MPTP mouse model. Along with the decreased expression of Faim2 after MPTP, this finding indicates that boosting Faim2 function might represent a therapeutic strategy for Parkinson disease.
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Association between preschool eczema and medication for attention‐deficit/hyperactivity disorder in school age
Authors: Johansson Emma Kristin , Ballardini Natalia , Kull Inger , Bergström Anna , Wahlgren Carl‐Fredrik 
Published: September 2016

AbstractBackgroundSeveral studies show an association between eczema and attention‐deficit/hyperactivity disorder (ADHD) in childhood, but the mechanisms and time sequence remain unclear. Information on the association between eczema and other disorders involving the central nervous system (CNS) is limited. The aim was to explore whether preschool eczema was associated with ADHD or other CNS‐associated disorders requiring pharmacotherapy at school age and to analyze whether eczema at other ages of childhood was associated with medication for ADHD.MethodsFrom a Swedish birth cohort, 3606 children were included in the analyses. At 1, 2, 4, 8, 12, and 16 years of age, their parents answered questionnaires regarding eczema the last year. Information on prescribed medications during school age (10–18 years of age) was derived by record linkage to the Swedish Prescribed Drug Register.ResultsA total of 1178 (32.7%) of the children had preschool eczema (eczema at 1, 2, and/or 4 years), and 162 (4.5%) of the children had dispensed ADHD medication at school age. Preschool eczema was not associated with ADHD medication at school age (crude odds ratio 1.16; 95% Confidence Intervals: 0.83–1.61). There was no significant association between preschool eczema and use of antidepressants, migraine drugs, or anti‐epileptics at school age. Infantile eczema, school‐age eczema, and eczema ever up to 16 years of age were not associated with ADHD medication at school age.ConclusionsIn this large birth cohort, there were no significant associations between preschool eczema and medications for ADHD, depression/anxiety/phobia, migraine, or epilepsy at school age.
Non‐IgE‐mediated gastrointestinal food allergies in children
Authors: Caubet Jean‐Christoph , Szajewska Hania , Shamir Raanan , Nowak‐Węgrzyn Anna 
Published: September 2016

AbstractNon‐IgE‐mediated gastrointestinal food allergic disorders (non‐IgE‐GI‐FA) including food protein‐induced enterocolitis syndrome (FPIES), food protein‐induced enteropathy (FPE), and food protein‐induced allergic proctocolitis (FPIAP) are relatively uncommon in infants and young children, but are likely under‐diagnosed. Non‐IgE‐GI‐FA have a favorable prognosis, with majority resolving by age 3–5 years. Diagnosis relies on the recognition of symptoms pattern in FPIAP and FPIES and biopsy in FPE. Further studies are needed for a better understanding of the pathomechanism, which will lead eventually to the development of diagnostic tests and treatments. Limited evidence supports the role of food allergens in subsets of constipation, gastroesophageal reflux disease, irritable bowel syndrome, and colic. The immunologic pathomechanism is not fully understood and empiric prolonged avoidance of food allergens should be limited to minimize nutrient deficiency and feeding disorders/food aversions in infants.
Streptococcus pyogenes as the cause of vulvovaginitis and balanitis in children
Authors: Randjelovic Gordana , Otasevic Suzana , Mladenovic‐Antic Snezana , Mladenovic Vesna , Radovanovic‐Velickovic Radmila , Randjelovic Marina , Bogdanovic Dragan 
Published: September 2016

AbstractBackgroundStreptococcus pyogenes (group A Streptococcus) is the etiological agent of perineal infection in children, consisting of perianal infection, vulvovaginitis and balanitis. If it is not properly diagnosed and treated, it can persist for many months and can cause severe complications. Furthermore, treatment with penicillin can be followed by failures and recurrences.MethodsWe report here the prevalence of S. pyogenes isolates in genital tract specimens from girls (n = 1692) with symptoms of vulvovaginitis and from boys (n = 52) with balanitis in the municipality of Nis, Southeast‐Serbia (the Western Balkans) in a 10 year period, and the seasonal distribution, patient age and sensitivity to bacitracin and antimicrobial drugs used in the treatment of streptococcal infection.ResultsStreptococcal vulvovaginitis was diagnosed in 2.30% of examinees. Of those cases, 64.10% were detected from April to September, and it was most common (71.79%) in girls aged 3–7 years. Streptococcal balanitis was diagnosed in two instances: in a 4‐year‐old boy and in a 7‐year‐old boy. S. pyogenes strains resistant to bacitracin were identified in five girls. Two isolates with M phenotype and five isolates with cMLSB phenotype were identified.ConclusionsStreptococcal vulvovaginitis was diagnosed less often in the present study, but it was still far more common than streptococcal balanitis in childhood. Bacitracin resistance of S. pyogenes strains should be taken into account in routine microbiological identification, and the detection of S. pyogenes isolates resistant to erythromycin requires surveillance in the present geographical territory.
Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy
Authors: Radtke Josephine , Dietze Nina , Fischer Lutz , Achilles Eike‐Gert , Li Jun , Scheidat Silke , Thaiss Friedrich , Nashan Bjoern , Koch Martina 
Published: September 2016

AbstractBackgroundBK polyomavirus (BKV) infection and BKV nephropathy (BKVN) are risk factors for allograft function and survival.MethodsWe retrospectively analyzed BK viremia and BKVN in 348 patients who received a kidney transplantation donated after brain death (n=232) or living donation (n=116) between 2008 and 2013. A total of 266 patients were treated with standard immunosuppression consisting of basiliximab induction, calcineurin inhibitor (CNI), and mycophenolic acid (MPA, n=219) or everolimus (n=47); 82 patients received more intense immunosuppression with lymphocyte depletion, CNI and MPA (n=38) or everolimus (n=44).ResultsBK viremia occurred in 33 (9.5%) patients in the first year and in 7 (2.0%) recipients in the second year after transplantation. BKVN occurred in 4 (1.1%) patients in the first year. Donor and recipient age, diabetes, previous transplantation, and type of transplantation (donated after brain death vs living donation) were not risk factors (P>.05). BK incidence did not differ depending on induction or maintenance immunosuppression.ConclusionIncidence of BK viremia is independent of recipient characteristics, type of transplantation as well as induction and maintenance immunosuppression.