bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformative agreements, publication venues and Open Access policies at the University of Milan
Authors: Berni Laura , Zucchini Francesco 
Published: September 2024

AbstractStarting from July 2020 at the University of Milan, one of the largest and most important Italian universities, the first transformative agreements with some major international scientific publishers have come into effect. These agreements allow corresponding authors to publish in open access without directly bearing the publication costs. From the perspective of corresponding authors, these agreements could increase the dissemination of their scientific output and, thereby, the impact on the scientific community. However, transformative agreements are part of a rapidly changing publishing market that already includes open access articles in both so‐called ‘Diamond’ and ‘Gold’ journals. The aim of our study is to understand to what extent the positioning of journals in impact rankings, the disciplinary field of the article, together with the career stage of the corresponding author, influence the choice to publish in a journal covered by transformative agreements rather than in other open access or hybrid journals. The results of our investigation draw attention to the importance of rules in Italy governing scientific careers in different disciplinary fields and potential unforeseen effects of policies favouring open access.
Large‐Scale High‐Density Multimode Optical Switch Matrix
Authors: Sun Shangsen , Tong Weiyu , Wang Qiansheng , Jiang Shan , Wu Bo , Zhang Wenkai , Zhang Hongguang , Xu Lu , Dong Jianji , Xiao Xi , Zhang Xinliang 
Published: September 2024

AbstractOptical switching technology is emerging as a solution to the limitations of traditional electronic switching. Combining optical switching with mode‐division multiplexing effectively overcomes the limitations of expanding switching capacity solely by increasing the number of ports. This paper introduces a compact four‐mode 2 × 2 optical switch and a four‐mode reconfigurable non‐blocking 4 × 4 optical switch matrix based on the Beneš architecture. The multimode 2 × 2 switch achieves an extinction ratio larger than 15 dB for all modes in the wavelength range of 1530–1590 nm. The multimode 4 × 4 switch matrix has an extinction ratio exceeding 9 dB for all modes and states in the C‐band, with a compact size (1.46 × 0.23 mm2) and low power consumption (0–154 mW). It supports high‐integrity 50 Gbaud PAM4 signal transmission with a bit error rate below the forward error correction limit. These devices pave the way for enhanced integration density and capacity in optical switching systems.
Empowered by representation: How plus‐size models create brand evangelists
Authors: Chauhan Vishakha , Gupta Mansi , Das Gopal 
Published: September 2024

AbstractTraditional beauty standards are evolving as brands embrace diversity and equity through inclusive communication strategies. This paradigm shift is evident in the transition from stereotypical slender models to the inclusion of more diverse plus‐size models in brand communication. However, an important question arises: Does the presence of a plus‐size model in an advertisement enhance consumer support for a brand? The present research encompasses six studies, including one field study and five experimental studies, that delve into the relationship between models' body size and brand evangelism. The findings demonstrate that featuring a plus‐size model in an advertisement enhances brand evangelism among consumers. Further, consumer empowerment is the underlying mechanism driving this effect. Finally, this research identifies the moderating role of empathy such that consumers with higher levels of empathy experience a heightened sense of empowerment through inclusive brand communication. By illuminating these dynamics, this research contributes to the growing literature of diversity, equity, and inclusion in brand communication.
Liver cirrhosis: molecular mechanisms and therapeutic interventions
Authors: Dong Zihe , Wang Yeying , Jin Weilin 
Published: September 2024

AbstractLiver cirrhosis is the end‐stage of chronic liver disease, characterized by inflammation, necrosis, advanced fibrosis, and regenerative nodule formation. Long‐term inflammation can cause continuous damage to liver tissues and hepatocytes, along with increased vascular tone and portal hypertension. Among them, fibrosis is the necessary stage and essential feature of liver cirrhosis, and effective antifibrosis strategies are commonly considered the key to treating liver cirrhosis. Although different therapeutic strategies aimed at reversing or preventing fibrosis have been developed, the effects have not be more satisfactory. In this review, we discussed abnormal changes in the liver microenvironment that contribute to the progression of liver cirrhosis and highlighted the importance of recent therapeutic strategies, including lifestyle improvement, small molecular agents, traditional Chinese medicine, stem cells, extracellular vesicles, and gut remediation, that regulate liver fibrosis and liver cirrhosis. Meanwhile, therapeutic strategies for nanoparticles are discussed, as are their possible underlying broad application and prospects for ameliorating liver cirrhosis. Finally, we also reviewed the major challenges and opportunities of nanomedicine‒biological environment interactions. We hope this review will provide insights into the pathogenesis and molecular mechanisms of liver cirrhosis, thus facilitating new methods, drug discovery, and better treatment of liver cirrhosis.
Genetic Risk Factors in Isolated Dystonia Escape Genome‐Wide Association Studies
Authors: Laabs Björn‐Hergen , Lohmann Katja , Vollstedt Eva‐Juliane , Reinberger Tobias , Nuxoll Lisa‐Marie , Kilic‐Berkmen Gamze , Perlmutter Joel S. , Loens Sebastian , Cruchaga Carlos , Franke Andre , Dobricic Valerija , Hinrichs Frauke , Grözinger Anne , Altenmüller Eckart , Bellows Steven , Boesch Sylvia , Bressman Susan B. , Duque Kevin R. , Espay Alberto J. , Ferbert Andreas , Feuerstein Jeanne S. , Frank Samuel , Gasser Thomas , Haslinger Bernhard , Jech Robert , Kaiser Frank , Kamm Christoph , Kollewe Katja , Kühn Andrea A. , LeDoux Mark S. , Lohmann Ebba , Mahajan Abhimanyu , Münchau Alexander , Multhaupt‐Buell Trisha , Pantelyat Alexander , Pirio Richardson Sarah E. , Raymond Deborah , Reich Stephen G. , Saunders Pullman Rachel , Schormair Barbara , Sharma Nutan , Sichani Azadeh Hamzehei , Simonyan Kristina , Volkmann Jens , Wagle Shukla Aparna , Winkelmann Juliane , Wright Laura J. , Zech Michael , Zeuner Kirsten E. , Zittel Simone , Kasten Meike , Sun Yan V. , Bäumer Tobias , Brüggemann Norbert , Ozelius Laurie J. , Jinnah Hyder A. , Klein Christine , König Inke R. 
Published: September 2024

AbstractBackgroundDespite considerable heritability, previous smaller genome‐wide association studies (GWASs) have not identified any robust genetic risk factors for isolated dystonia.ObjectiveThe objective of this study was to perform a large‐scale GWAS in a well‐characterized, multicenter sample of >6000 individuals to identify genetic risk factors for isolated dystonia.MethodsArray‐based GWASs were performed on autosomes for 4303 dystonia participants and 2362 healthy control subjects of European ancestry with subgroup analysis based on age at onset, affected body regions, and a newly developed clinical score. Another 736 individuals were used for validation.ResultsThis GWAS identified no common genome‐wide significant loci that could be replicated despite sufficient power to detect meaningful effects. Power analyses imply that the effects of individual variants are likely very small.ConclusionsModerate single‐nucleotide polymorphism–based heritability indicates that common variants do not contribute to isolated dystonia in this cohort. Sequence‐based GWASs (eg, by whole‐genome sequencing) might help to better understand the genetic basis. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Current nanocomposite advances for biomedical and environmental application diversity
Authors: Mamidi Narsimha , Delgadillo Ramiro M. V. , Sustaita Alan O. , Lozano Karen , Yallapu Murali M. 
Published: September 2024

AbstractNanocomposite materials are emerging as key players in addressing critical challenges in healthcare, energy storage, and environmental remediation. These innovative systems hold great promise in engineering effective solutions for complex problems. Nanocomposites have demonstrated various advantages such as simplicity, versatility, lightweight, and potential cost‐effectiveness. By reinforcing synthetic and natural polymers with nanomaterials, a range of nanocomposites have exhibited unique physicochemical properties, biocompatibility, and biodegradability. Current research on nanocomposites has demonstrated promising clinical and translational applications. Over the past decade, the production of nanocomposites has emerged as a critical nano‐structuring methodology due to their adaptability and controllable surface structure. This comprehensive review article systematically addresses two principal domains. A comprehensive survey of metallic and nonmetallic nanomaterials (nanofillers), elucidating their efficacy as reinforcing agents in polymeric matrices. Emphasis is placed on the methodical design and engineering principles governing the development of functional nanocomposites. Additionally, the review provides an exhaustive examination of recent noteworthy advancements in industrial, environmental, biomedical, and clinical applications within the realms of nanocomposite materials. Finally, the review concludes by highlighting the ongoing challenges facing nanocomposites in a wide range of applications.
Advances in reversible covalent kinase inhibitors
Authors: Zhao Zheng , Bourne Philip E. 
Published: September 2024

AbstractReversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors yet avoid permanent protein‐modification‐induced adverse effects. Over the last decade, RCKIs have been reported to target different kinases, including Atypical group of kinases. Currently, three RCKIs are undergoing clinical trials. Here, advances in RCKIs are reviewed to systematically summarize the characteristics of electrophilic groups, chemical scaffolds, nucleophilic residues, and binding modes. In so doing, we integrate key insights into privileged electrophiles, the distribution of nucleophiles, and hence effective design strategies for the development of RCKIs. Finally, we provide a further perspective on future design strategies for RCKIs, including those that target proteins other than kinases.
The phytopathogen Xanthomonas campestris senses and effluxes salicylic acid via a sensor HepR and an RND family efflux pump to promote virulence in host plants
Authors: Song Kai , Li Ruifang , Cui Ying , Chen Bo , Zhou Lian , Han Wenying , Jiang Bo‐Le , He Ya‐Wen 
Published: September 2024

AbstractSalicylic acid (SA) plays an essential role in plant defense against biotrophic and semi‐biotrophic pathogens. Following pathogen recognition, SA biosynthesis dramatically increases at the infection site of the host plant. The manner in which pathogens sense and tolerate the onslaught of SA stress to survive in the plant following infection remains to be understood. The objective of this work was to determine how the model phytopathogen Xanthomonas campestris pv. campestris (Xcc) senses and effluxes SA during infection inside host plants. First, RNA‐Seq analysis identified an SA‐responsive operon Xcc4167–Xcc4171, encoding a MarR family transcription factor HepR and an RND (resistance‐nodulation‐cell division) family efflux pump HepABCD in Xcc. Electrophoretic mobility shift assays and DNase I footprint analysis revealed that HepR negatively regulated hepABCD expression by specifically binding to an AT‐rich region of the promoter of the hepRABCD operon, Phep. Second, isothermal titration calorimetry and further genetic analysis suggest that HepR is a novel SA sensor. SA binding released HepR from its cognate promoter Phep and then induced the expression of hepABCD. Third, the RND family efflux pump HepABCD was responsible for SA efflux. The hepRABCD cluster was also involved in the regulation of culture pH and quorum sensing signal diffusible signaling factor turnover. Finally, the hepRABCD cluster was transcribed during the XC1 infection of Chinese radish and was required for the full virulence of Xcc in Chinese radish and cabbage. These findings suggest that the ability of Xcc to co‐opt the plant defense signal SA to activate the multidrug efflux pump may have evolved to ensure Xcc survival and virulence in susceptible host plants.
Millimeter micro‐coaxial beam steering array for high‐speed satellite communications
Authors: Li Bin , Feng Linping , Li Yun , Liu Shuo 
Published: September 2024

AbstractWide‐band low‐loss passive beam steering array presents to be essential part of the RF front‐ends for high‐speed detection during deep space exploration missions. In this letter, the copper‐based additive manufacturing technology is proposed for the implementation of low‐profile (~0.1λ) antenna design. Adopting the micro‐coaxial line as the basic design unit enables wide bandwidth design. In addition, the broadband designs of Butler matrix, planar antenna element, and transmission transitions are proposed, respectively. The miniaturization of the metallic patch antenna is realized using a double slotted design, ensuring an array space of ~0.5λ, which beneficial for the low‐lobe beam steering. Experimental results show that the antenna array with an overall size of 39 × 29 × 0.5 mm presents four beams located at ±14° and ±43°, respectively. The bandwidth of return loss better than −10 dB ranges from 65 to 71 GHz. The measured result matches well with the simulated ones, which makes its potential operation for satellite applications.
Reducing treatment time for robotic radiosurgery by considering path efficiency during node selection
Authors: Hagström Theodor , Andersson Björn , Fredriksson Albin 
Published: September 2024

AbstractBackgroundRobotic radiosurgery treatments allow for precise non‐coplanar beam delivery by utilizing a robot equipped with a linac that traverses through a set of predetermined nodes. High quality treatment plans can be produced but treatment times can grow large, with one substantial component being the robot traversal time.PurposeThe aim of this study is to reduce the treatment time for robotic radiosurgery treatments by introducing algorithms for reducing the robot traversal time. The algorithms are integrated into a commercial treatment planning system.MethodsFirst, an optimization framework for robotic radiosurgery planning is detailed, including a heuristic optimization method for node selection. Second, two methods aimed at reducing the traversal time are introduced. One utilizes a centrality measure focusing on the structure of the node network, while the other is based on the direct computation of traversal times during optimization. A comparison between plans with and without the time‐reducing algorithms is made for three brain cases and one liver case with basis in treatment time, plan quality, monitor units, and network structure of the selected nodes.ResultsLarge decreases in traversal times are obtained by the traversal time reducing algorithms, with reductions of up to 49 % in the brain cases and 31 % in the liver case. The resulting reductions in treatment times are up to 30 % and 13 %, respectively. Small differences in plan quality are observed, with similar dose‐volume histograms, dose distributions, and conformity/gradient indices.ConclusionsThe total treatment time of the robotic radiosurgery treatments can be reduced by selecting nodes with more efficient robot traversal paths, while maintaining plan quality.
Electrophysiological features of the peripheral neuropathy in patients with pathologic biallelic RFC1 repeat expansions
Authors: Calezis Claudia , Bonello‐Palot Nathalie , Verschueren Annie , Azulay Jean‐Philippe , Fortanier Etienne , Grapperon Aude‐Marie , Kouton Ludivine , Gallard Julien , Salort‐Campana Emmanuelle , Attarian Shahram , Delmont Emilien 
Published: September 2024

AbstractIntroduction/AimsCerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) is caused by RFC1 expansions. Sensory neuronopathy, polyneuropathy, and involvement of motor, autonomic, and cranial nerves have all been described with RFC1 expansions. We aimed to describe the electrodiagnostic features of patients with RFC1 expansions through multimodal electrophysiological investigations.MethodsThirty‐five patients, with a median age of 70 years, and pathologic biallelic repeat expansions in the RFC1 gene, were tested for motor and sensory nerve conduction, flexor carpi radialis (FCR) and soleus H‐reflexes, blink reflex, electrochemical skin conductance, sympathetic skin response (SSR), and heart rate variability with deep breathing (HRV).ResultsOnly 16 patients (46%) exhibited the full clinical CANVAS spectrum. Distal motor amplitudes were normal in 30 patients and reduced in the legs of five patients. Distal sensory amplitudes were bilaterally reduced in a non‐length dependent manner in 30 patients. Conduction velocities were normal. Soleus H‐reflexes were abnormal in 19/20 patients of whom seven had preserved Achilles reflexes. FCR H‐reflexes were absent or decreased in amplitude in 13/14 patients. Blink reflex was abnormal in 4/19 patients: R1 latencies for two patients and R2 latencies for two others. Fourteen out of 31 patients (45%) had abnormal results in at least one autonomic nervous system test, either for ESC (12/31), SSR (5/14), or HRV (6/19).DiscussionLess than half of the patients with RFC1 expansions exhibited the full clinical CANVAS spectrum, but nearly all exhibited typical sensory neuronopathy and abnormal H‐reflexes. Involvement of small nerve fibers and brainstem neurons was less common.
Risk‐Aware SDN Defense Framework Against Anti‐Honeypot Attacks Using Safe Reinforcement Learning
Authors: Gao Dongying , Guo Caiwei , Zhang Yi , Ji Wen , Lv Zhilei , Li Zheng , Zhang Kunsan , Lin Ruibin 
Published: September 2024

ABSTRACTThe development of multiple attack methods by external attackers in recent years poses a huge challenge to the security and efficient operation of software‐defined networks (SDN), which are the core of operational controllers and data storage. Therefore, it is critical to ensure that the normal process of network interaction between SDN servers and users is protected from external attacks. In this paper, we propose a risk‐aware SDN defense framework based on safe reinforcement learning (SRL) to counter multiple attack actions. Specifically, the defender uses SRL to maximize the utility by choosing to provide a honeypot service or pseudo‐honeypot service within predefined security constraints, while the external attacker maximizes the utility by choosing an anti‐honeypot attack or masquerade attack. To describe the system risk in detail, we introduce the risk level function to model the simultaneous dynamic attack and defense processes. Simulation results demonstrate that our proposed risk‐aware scheme improves the defense utility by 17.5% and 142.4% and reduces the system risk by 42.7% and 59.6% compared to the QLearning scheme and the Random scheme, respectively.
Glioma monitoring and assessment: Utility of amide proton transfer MRI
Authors: Fothergill Aisling E. , Djoukhadar Ibrahim , Higgins David , Coope David , Thomas Owen , Parkes Laura M. 
Published: September 2024

AbstractMagnetic resonance imaging (MRI) plays a key role in the planning of glioma biopsy as well as postoperative monitoring for recurrence or progression. This review describes amide proton transfer (APT) MRI and its application to glioma imaging, including the use of APT MRI to address unmet clinical needs, common APT sequence parameter choices, and post‐processing methods. APT is a chemical exchange saturation transfer MRI technique that is sensitive to exchanging protons between water molecules and proteins and peptides containing amide groups in tissue. APT has shown promise in several areas including: differentiating glioma grading, correlation to cellular proliferation, association with molecular markers, and distinguishing pseudo‐progression from true progression. Multiple studies have shown that APTw values are affected by tumor markers including isocitrate dehydrogenase status and O6‐methylguanine‐DNA‐methyltransferase promoter status, demonstrating the potential for APT MRI. APT has also been shown to correlate with markers of cellular proliferation, including Ki‐67 index and low apparent diffusion coefficient on diffusion‐weighted imaging. Finally, this review also examines the potential limitations of APT MRI in clinical glioma imaging including the lack of standardization of acquisition and processing as well as the impact of 𝑇1, nuclear overhauser effect and magnetization transfer on the APT signal.
Feasibility and acceptability of a parent–child intervention to improve step count in childhood cancer survivors exposed to cardiotoxic therapy: The STEP UP for FAMILIES Study
Authors: Friedman Danielle Novetsky , Lavery Jessica A. , Moskowitz Chaya S. , Gordon Isabella , Gilliland Jaime , Scott Jessica , Diotallevi Deborah , Pottenger Elaine , Wilson Nadia , Antal Zoltan , Ramjan Sameera , Sands Stephen 
Published: September 2024

AbstractBackgroundLate morbidity after childhood cancer may be mitigated by healthy lifestyle behaviors. We piloted a game‐based, parent–child digital intervention to increase activity in sedentary survivors.MethodsSurvivors aged 10–16 treated with cardiotoxic therapy and not meeting US physical activity guidelines were enrolled in a single‐arm study with a parent. Following a 14‐day run‐in, participants chose a prespecified step goal and wore an accelerometer daily for 24 weeks (12‐week game‐based intervention; 12‐week follow‐up). Participants completed the Acceptability of Intervention Measure (AIM) at 24 weeks; a subset of dyads completed qualitative interviews.ResultsAmong 129 eligible survivors, 27 enrolled (20.9% participation rate) with a parent. Four dyads were removed during the 14‐day run‐in period due to noncompliance. Among the 23 dyads who continued to the study, the tracker was worn for 95% of days during the 12‐week intervention (95% confidence interval [CI]: 94–96) and 81% during the 12‐week follow‐up (95% CI: 79–82). Overall, the prespecified step goal was met for 64% (95% CI: 63–66) of days during the intervention and 37% (95% CI: 35–38) during the follow‐up. At the end of study, 17/23 dyads responded to AIM; 82% of survivors and 94% of parents reported the intervention as acceptable. During qualitative interviews (n = 5), dyads noted that they liked the accountability of the “buddy system,” but would have liked more personalized goal‐setting.ConclusionsDespite high ratings of acceptability among participants, difficulties with sustained adherence and retention were encountered in this parent–child gamification intervention. Alternate, tailored designs should be considered in the future.