bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical characteristics of sarcoid arthropathy based on a prospective cohort study
Authors: Kobak Senol , Sever Fidan , Usluer Ozan , Goksel Tuncay , Orman Mehmet 
Published: September 2016

Background: Sarcoidosis is known as a Th1-mediated disease, which can mimic many primary rheumatologic diseases or sometimes co-exist with them. Clinical characteristics of sarcoid arthropathy are not well described and the studies reported in the literature so far are mostly based on data from referrals. The aim of this study was to evaluate the incidence and clinical characteristics of sarcoid arthropathy. Methods: All our patients were prospectively evaluated in our rheumatology outpatient center from 2011 to 2015. A total of 114 (32 male) patients with sarcoidosis who were admitted to our clinic were included in the study. Clinical, demographical, laboratory, radiological and histological data of these patients obtained during 4-year follow-up and treatment period were compiled and analyzed. Results: The mean patient age was 48.1 years (range, 20–82 years), and the mean disease duration was 40.5 months (range, 1–300 months). Sarcoid arthritis was observed in 71 (62.3%), and arthralgia in 106 (92.9%) patients. Out of the 71 patients with arthritis, 61 (85.9%) had involvement of ankle, 7 (9.8%) knee, 2 (2.8%) wrist, MCP and PIP joints, and 1 (1.4%) had shoulder periarthritis. Oligoarthritis (two to four joints) was the most common pattern followed by monoarthritis and polyarthritis. Arthritis and erytjhema nodosum and arthritis and female sex was found to be correlated ( p = 0.03 and p = 0.001). Again, in patients with arthritis, even higher levels of CRP/ESR as well as ANA and RF positivity were observed ( p = 0.03, p = 0.01, p = 0.01, and p = 0.02, respectively). A total of 11 patients had another rheumatic pathology concurrent with sarcoidosis. Conclusions: Inflammatory arthritis occurs in a majority of patients with sarcoidosis. Acute arthritis with bilateral ankle involvement is the most common pattern of sarcoid arthropathy. Sarcoidosis can mimic many primary rheumatic diseases or may coexist with them. Sarcoidosis should be considered not only as a mimicker but also as a Th1-mediated primary rheumatologic pathology.
Ease of Use of the Insulin Glargine 300 U/mL Pen Injector in Insulin-Naïve People With Type 2 Diabetes
Authors: Pohlmeier Harald , Berard Lori , Brulle-Wohlhueter Claire , Wu Junlong , Dahmen Raphael , Nowotny Irene , Klonoff David 
Published: September 2016

Background: Insulin glargine 300 U/mL (Gla-300) contains the same active ingredient as glargine 100 U/mL (Gla-100), and provides the same number of units in one-third of the volume. The SoloSTAR® injector pen has been modified to ensure accurate administration of this reduced volume and to improve user experience. Methods: Insulin- and pen-naïve adults with type 2 diabetes (T2DM) inadequately controlled with oral antihyperglycemic drugs, who had glycated hemoglobin (HbA1c) levels of 7.0-11.0 % (53-97 mmol/mol) were studied. They received once-daily Gla-300 in this 4-week, multicenter, open-label, single-arm study (NCT02227212). Ease of use/ease of learning (the primary endpoint), glycemic control, safety, and reliability of the disposable (prefilled) Gla-300 injector pen (secondary endpoints) were evaluated. Results: At week 4, 95.0% of 40 participating subjects assessed the pen as excellent/good and none as poor/very poor; 97.5% would recommend it to others. Total Diabetes Treatment Satisfaction Questionnaire scores were stable throughout the study. Mean (SD) fasting plasma glucose levels decreased from 166.1 (35.0) mg/dL at baseline to 124.2 (41.1) mg/dL at week 4. No product technical complaints (PTCs) or adverse events (AEs) related to PTCs were reported. The number of subjects experiencing hypoglycemic events of any kind and the incidence of AEs were low. No serious AEs were reported. Conclusions: The Gla-300 injector pen is easy to use and easy to learn to use, with demonstrable reliability and high degrees of acceptance and treatment satisfaction. Once-daily Gla-300 basal insulin treatment was well tolerated and effective in pen- and insulin-naïve adult T2DM subjects.
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature
Authors: Kavanagh David , McGlasson Sarah , Jury Alexa , Williams Jac , Scolding Neil , Bellamy Chris , Gunther Claudia , Ritchie Diane , Gale Daniel P. , Kanwar Yashpal S. , Challis Rachel , Buist Holly , Overell James , Weller Belinda , Flossmann Oliver , Blunden Mark , Meyer Eric P. , Krucker Thomas , Evans Stephen J. W. , Campbell Iain L. , Jackson Andrew P. , Chandran Siddharthan , Hunt David P. J. 
Published: September 2016

Key PointsType I IFN therapies can cause a dose-dependent TMA. Recombinant type I IFN therapies should be stopped at the earliest opportunity in patients who develop TMA.
RETRACTED ARTICLE: Boundary behaviors for linear systems of subsolutions of the stationary Schrödinger equation
Authors: Jiang Zongcai , Usó Francisco Marco 
Published: September 2016

AbstractThis paper investigates the boundary behaviors for linear systems of subsolutions of the stationary Schrödinger equation, which contain unstable subsystems. Our first aim is to establish a state-feedback switching law guaranteeing the continuous-time systems to be uniformly exponentially stable. And then we present sufficient and necessary for the stability of the systems with two Schrödinger subsystems. Finally, an illustrative example is given to verify the result.
Control of the Environment in the Operating Room
Authors: Katz Jonathan D. 
Published: September 2016

There is a direct relationship between the quality of the environment of a workplace and the productivity and efficiency of the work accomplished. Components such as temperature, humidity, ventilation, drafts, lighting, and noise each contribute to the quality of the overall environment and the sense of well-being of those who work there.
The modern operating room is a unique workplace with specific, and frequently conflicting, environmental requirements for each of the inhabitants. Even minor disturbances in the internal environment of the operating room can have serious ramifications on the comfort, effectiveness, and safety of each of the inhabitants. A cool, well-ventilated, and dry climate is optimal for many members of the surgical team. Any significant deviation from these objectives raises the risk of decreased efficiency and productivity and adverse surgical outcomes. A warmer, more humid, and quieter environment is necessary for the patient. If these requirements are not met, the risk of surgical morbidity and mortality is increased. An important task for the surgical team is to find the correct balance between these 2 opposed requirements. Several of the components of the operating room environment, especially room temperature and airflow patterns, are easily manipulated by the members of the surgical team. In the following discussion, we will examine these elements to better understand the clinical ramifications of adjustments and accommodations that are frequently made to meet the requirements of both the surgical staff and the patient.
HSV presence in brains of individuals without dementia: the TASTY brain series
Authors: Olsson Jan , Lövheim Hugo , Honkala Emma , Karhunen Pekka J. , Elgh Fredrik , Kok Eloise H. 
Published: September 2016

ABSTRACT
Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (Aβ) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had Aβ aggregations, most of those with Aβ aggregations did not have HSV present in the brain tissue.
Characterization of proteome dynamics during growth in oleate reveals a new peroxisome-targeting receptor
Authors: Yifrach Eden , Chuartzman Silvia G. , Dahan Noa , Maskit Shiran , Zada Lior , Weill Uri , Yofe Ido , Olender Tsviya , Schuldiner Maya , Zalckvar Einat 
Published: September 2016

ABSTRACT
To optimally perform the diversity of metabolic functions that occur within peroxisomes, cells must dynamically regulate peroxisome size, number and content in response to the cell state and the environment. Except for transcriptional regulation little is known about the mechanisms used to perform this complicated feat. Focusing on the yeast Saccharomyces cerevisiae, we used complementary high-content screens to follow changes in localization of most proteins during growth in oleate. We found extensive changes in cellular architecture and identified several proteins that colocalized with peroxisomes that had not previously been considered peroxisomal proteins. One of the newly identified peroxisomal proteins, Ymr018w, is a protein with an unknown function that is similar to the yeast and human peroxisomal targeting receptor Pex5. We demonstrate that Ymr018w is a new peroxisomal-targeting receptor that targets a subset of matrix proteins to peroxisomes. We, therefore, renamed Ymr018w, Pex9, and suggest that Pex9 is a condition-specific targeting receptor that enables the dynamic rewiring of peroxisomes in response to metabolic needs. Moreover, we suggest that Pex5-like receptors might also exist in vertebrates.
Ablation and mechanical investigation of heat vulcanizing silicone rubber (HVSR) composite containing carbon fibers
Authors: Liu Yanhui , Su Jingyu , Yin Zhengshuai , Li Yong , Zhi Ye , Gao Jinglong 
Published: September 2016

Abstract
In this study, heat vulcanizing silicone rubber (HVSR) composites were prepared and the impact of the addition of carbon fibers (CFs) on the mechanical and ablation properties of the composite was demonstrated. It was found that with increasing content of CFs, the tensile property and the hardness of the composite increased significantly. The back-face temperature, the ablation rate and the ablation mechanism of the composite were discussed based on the data derived from several characterization methods, including oxygen-acetylene ablation device, scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared (FTIR). Along with the increasing of the content of CFs, the mass and linear ablation rates both decreased, but the back-face temperature increased. The interaction between ablation layer and the composite became intense due to the addition of the CFs, which led to the difficult peel-off of the ablation layer. Four layers can be formed after the oxygen-acetylene ablation of the composite including the surface layer, the carbonization layer, the pyrolysis layer and the matrix layer. The ablation mechanism was also proposed. It mainly involves the carbonization of the composite, the ceramization of SiC and the shielding effect of the ablated layer.
Maximal Strength Performance and Muscle Activation for the Bench Press and Triceps Extension Exercises Adopting Dumbbell, Barbell, and Machine Modalities Over Multiple Sets
Authors: Farias Déborah de Araújo , Willardson Jeffrey M. , Paz Gabriel A. , Bezerra Ewertton de S. , Miranda Humberto 
Published: September 2016

Abstract
Farias, DdA, Willardson, JM, Paz, GA, Bezerra, EdS, and Miranda, H. Maximal strength performance and muscle activation for the bench press and triceps extension exercises adopting dumbbell, barbell and machine modalities over multiple sets. J Strength Cond Res 31(7): 1879–1887, 2017—The purpose of this study was to investigate muscle activation, total repetitions, and training volume for 3 bench press (BP) exercise modes (Smith machine [SMBP], barbell [BBP], and dumbbell [DBP]) that were followed by a triceps extension (TE) exercise. Nineteen trained men performed 3 testing protocols in random order, which included: (P1) SMBP + TE; (P2) BBP + TE; and (P3) DBP + TE. Each protocol involved 4 sets with a 10-repetition maximum (RM) load, immediately followed by a TE exercise that was also performed for 4 sets with a 10RM load. A 2-minute rest interval was adopted between sets and exercises. Surface electromyographic activity was assessed for the pectoralis major (PM), anterior deltoid (AD), biceps brachii (BB), and triceps brachii (TB). The results indicated that significantly higher total repetitions were achieved for the DBP (31.2 ± 3.2) vs. the BBP (27.8 ± 4.8). For the TE, significantly greater volume was achieved when this exercise was performed after the BBP (1,204.4 ± 249.4 kg) and DBP (1,216.8 ± 287.5 kg) vs. the SMBP (1,097.5 ± 193 kg). The DBP elicited significantly greater PM activity vs. the BBP. The SMBP elicited significantly greater AD activity vs. the BBP and DBP. During the different BP modes, the SMBP and BBP elicited significantly greater TB activity vs. the DBP. However, the DBP elicited significantly greater BB activity vs. the SMBP and BBP, respectively. During the succeeding TE exercise, significantly greater activity of the TB was observed when this exercise was performed after the BBP vs. the SMBP and DBP. Therefore, it seems that the variation in BP modes does influence both repetition performance and muscle activation patterns during the TE when these exercises are performed in succession.
Influence of Competition Day on Cognitive Control and HRV in Young Male Gymnasts
Authors: Sartor Francesco , Capuzzoni Silvia , Rospo Gianluca , La Torre Antonio , Vailati Fulvio , Vailati Emanuele 
Published: September 2016

Abstract
Sartor, F, Capuzzoni, S, Rospo, G, La Torre, A, Vailati, F, and Vailati, E. Influence of competition day on cognitive control and HRV in young male gymnasts. J Strength Cond Res 31(7): 1982–1993, 2017—In gymnastics, high levels of executive attention and physical and coordinative capacities are required. However, training planning does not usually account for dynamic alterations in cognitive capacity. This study investigated whether cognitive capacity was altered by the approach of a competition. Ten elite male gymnasts (16 ± 2 years, 57.3 ± 16.1 kg, 1.64 ± 1.27 m) were monitored for sleep, life demands, rating of perceived exertion (RPE), and pain, starting 5 days before the competition and up to 5 days after it. Stroop task performance and concomitant heart rate variability (HRV) were monitored 5 days and 1 day before the competition and then 1 and 5 days after. Sleep and life demands were not affected by the competition. Localized pain ranged from mild to moderate levels throughout the observation period. It weakly correlated with RPE (r = 0.241, p = 0.010) and moderately with number of errors (NoEs) (r = 0.639, p = 0.047). The RPE was higher for the competition day (p = 0.002). Median reaction times during the Stroop task were higher in the period preceding the competition (p < 0.001) for similar NoEs. The HRV during the congruent stimuli task showed higher root mean square differences of successive beats, portion of normal to normal intervals exceeding 50 milliseconds, and high frequency after the competition (p ≤ 0.05). Poincare plot SD2 showed a positive correlation with Stroop task NoEs (r = 0.590, p < 0.001). In conclusion, the period preceding an important competition affected cognitive performance and HRV in young male gymnasts. A practical implication of this study is that training loads could be adjusted according to mental stress before a competition.
Influence of Physical Maturity Status on Sprinting Speed Among Youth Soccer Players
Authors: McCunn Robert , Weston Matthew , Hill John K.A. , Johnston Rich D. , Gibson Neil V. 
Published: September 2016

Abstract
McCunn, R, Weston, M, Hill, JKA, Johnston, RD, and Gibson, NV. Influence of physical maturity status on sprinting speed among youth soccer players. J Strength Cond Res 31(7): 1795–1801, 2017—The relative age effect is well documented with the maturation-selection hypothesis the most common explanation; however, conflicting evidence exists. We observed the birth date distribution within an elite junior soccer academy. The influence of physical maturity status on anthropometric variables and sprinting ability was also investigated. Annual fitness testing was conducted over an 8-year period with a total of 306 players (age: 12.5 ± 1.7 years [range: 9.7–16.6 years]; stature: 156.9 ± 12.9 cm; mass: 46.5 ± 12.5 kg) drawn from 6 age categories (under-11s to under-17s) who attended the same Scottish Premiership club academy. Measurements included mass, stature, maturity offset and 0–15 m sprint. Odds ratios revealed a clear bias toward recruitment of players born in quartile 1 compared with quartile 4. The overall effect (all squads combined) of birth quartile was very likely small for maturity offset (0.85 years; 90% confidence interval [CI], 0.44–1.26 years) and stature (6.2 cm; 90% CI, 2.8–9.6 cm), and likely small for mass (5.1 kg; 90% CI, 1.7–8.4 kg). The magnitude of the relationship between maturity offset and 15-m sprinting speed ranged from trivial for under-11s (r = 0.01; 90% CI, −0.14 to 0.16) to very likely large for under-15s (r = −0.62; −0.71 to −0.51). Making decisions about which players to retain and release should not be based on sprinting ability around the under-14 and under-15 age categories because any interindividual differences may be confounded by transient inequalities in maturity offset.
Using Loaded and Unloaded Jumps to Increase Speed and Power Performance in Elite Young and Senior Soccer Players
Authors: Loturco Irineu , Pereira Lucas A. , Kobal Ronaldo , Nakamura Fábio Y. 
Published: September 2016

ABSTRACT
SPEED AND POWER ABILITIES ARE PROGRESSIVELY REQUIRED IN CONTEMPORARY SOCCER TO ENABLE PLAYERS TO FULFILL THE DEMANDS OF A COMPETITIVE MATCH. HOWEVER, THERE ARE LIMITED SCIENTIFICALLY BASED RECOMMENDATIONS RELATED TO TRAINING STRATEGIES ABLE TO IMPROVE THESE NEUROMUSCULAR CAPACITIES IN SOCCER ATHLETES. THIS ARTICLE HIGHLIGHTS THE EVIDENCE AVAILABLE IN THE LITERATURE WHILE ALSO APPLYING IT TO STRENGTH AND CONDITIONING PROFESSIONALS WHO SEEK EFFECTIVE APPROACHES TO INCREASE SPRINT AND JUMP PERFORMANCES IN ELITE YOUNG AND SENIOR SOCCER PLAYERS.
Leishmaniasis visceral en Medula Ósea
Authors: Méndez López Max A. , López Villegas Jorge 
Published: September 2016

Una mujer de 47 años, fue evaluada en Emergencias con fiebre y pancitopenia, con velocidad de eritrosedimentación en 160mm/h (0-20mm/h) y deshidrogenasa láctica en 980 U/L (140-280 U/L). Había sido diagnosticada VIH positiva desde hace 7 años y se mantenía con terapia antiretroviral hasta 6 meses atrás cuando decidió abandonar el seguimiento y medicación. A su llegada, el ultrasonido de abdomen documentó hepatoesplenomegalia sin adenopatías. Se puede apreciar en las imágenes un histiocito fagocitando múltiples leishmania (izquierda). El kinetoplasto y la apariencia del núcleo en “doble punto” (flecha) es de gran utilidad para la identificación morfológica de Leishmania donovani, confirmado posteriormente con cultivo de médula ósea. La diseritropoiesis y la plasmocitosis son frecuentes en estos pacientes y sumado a los efectos medulares del virus y los medicamentos, el cuadro es diagnóstico diferencial mandatorio de Síndrome Mielodisplásico.
APPLICATION OF DATA ASSIMIMILATION FOR PARAMETER CORRECTION IN SUPER CAVITY MODELLING
Authors: Ha Tran Thu , Son Nguyen Anh , Hai Duong Ngoc , Phong Nguyen Hong 
Published: September 2016

On the imperfect water entry, a high speed slender body moving in the forward direction rotates inside the cavity. The super cavity model describes the very fast motion of body in water. In the super cavity model the drag coefficient plays important role in body's motion. In some references this drag coefficient is simply chosen by different values in the interval 0.8-1.0. In some other references this drag coefficient is written by the formula with is the cavity number, is the angle of body axis and flow direction, is a parameter chosen from the interval 0.6-0.85. In this paper the drag coefficient is written with fixed and the parameter is corrected so that the simulation body velocities are closer to observation data. To find the convenient drag coefficient the data assimilation method by differential variation is applied. In this method the observing data is used in the cost function. The data assimilation is one of the effected methods to solve the optimal problems by solving the adjoin problems and then finding the gradient of cost function.
New light on vitamin B12: The adenosylcobalamin-dependent photoreceptor protein CarH
Authors: Chemaly Susan M. 
Published: September 2016

Adenosylcobalamin (AdoCbl), or coenzyme B12, is a cofactor for enzymes important in metabolism in humans (and other mammals) and bacteria. AdoCbl contains a Co-C bond and is extremely light sensitive, but, until recently, this light sensitivity appeared to have no physiological function. Recently, AdoCbl has been found to act as cofactor for a photoreceptor protein (CarH) that controls the expression of DNA coding for transcription of the proteins needed for synthesis of carotenes in certain non-photosynthetic bacteria. In 2015, the X-ray crystal structures of two dark states of the photoreceptor protein from the bacterium Thermus thermophilus were determined: CarH bound to AdoCbl and CarH bound to a large portion of the cognate DNA operator (and AdoCbl); a light state was also determined in which CarH was bound to cobalamin in which the Co-C bond had been broken. The breaking of the Co-C bond of Ado-Cbl acts as a trigger for the regulatory switch that allows the transcription of DNA. In the two dark states AdoCbl is bound to a conserved histidine from CarH, which displaces the lower 5,6-dimethylbenzimidazole ligand of AdoCbl. In the light state the 5’-deoxyadenosyl group of AdoCbl is replaced by a second histidine from CarH, giving a bis-histidine cobalamin and 4’,5’-anhydroadenosine. Genes for B12-dependent photoreceptors are widespread in bacteria. Control of DNA transcription may represent an evolutionarily ancient function of AdoCbl, possibly pre-dating its function as a protein cofactor.
Significance:

A new function for adenosylcobalamin, a light-sensitive form of vitamin B12 with a Co-C bond, has been discovered in bacteria
Some non-photosynthetic bacteria use adenosylcobalamin as a cofactor for the protein CarH, which controls DNA transcription
Three X-ray crystal structures of CarH have been determined: bound to adenosylcobalamin, DNA and after light exposure
A mechanism of action for CarH, based on its structure and on model reactions of vitamin B12, is proposed