bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical Profiling of Aquilaria malaccensis Lam. Essential Oils and their Antiproliferative Potential against HeLa Human Cervical Cancer Cells
Authors: Zaid Atiqah , Alkatib Huda Hisham , Sharulezam Siti Nurhidayah , Yahaya Noorfatimah , Lee Tien Ping , Sreenivasan Sasidharan , Wong Yong Foo 
Published: September 2024

Background:
Aquilaria malaccensis Lam. is one of the very few lign-aloes trees that can
produce highly valuable resin-impregnated heartwood, commonly known as agarwood.

Aim:
This study aimed to determine the chemical profile of A. malaccensis essential oil and describe
its antiproliferative effects against the HeLa cervical cancer cell line for the first time.

Method:
The essential oils hydro-distilled from agarwood were characterised using GC−MS with the
aid of spectral deconvolution. The antiproliferative effects were evaluated via the MTT assay.

Result:
A total of 143 metabolites were tentatively identified in two different grades of essential oils,
which accounted for 56.80% and 78.19% of the total ion counts, respectively. These metabolites
were distributed over the chemical families of monoterpenes, sesquiterpenes, cyclic hydrocarbons,
and others. The essential oils exhibited antiproliferative activities, with IC50 values of 79.42 and
128.77 μg/mL, respectively.

Conclusion:
The results have suggested the chemical differences in secondary compounds to be the
main factor contributing to the decrease in cell viability. Further investigations are warranted to
understand its mechanisms of action and its potential use in cervical cancer treatment.
Combination of Intracanal Medicines with Zinc Oxide Nanoparticles for
Effective Eradication of Enterococcus faecalis
Authors: Baseri Milad , Memar Mohammad Yousef , Zohdi Mahsa , Samiei Mohammad , Dizaj Solmaz Maleki , Naseri Amirreza , Radmand Faraz , Torab Ali 
Published: September 2024

Background:
Intracanal-resistant infections are the most important reason for root canal treatment failure. Therefore, cleaning the root canals is crucial. The efficiency of nanomedicines in eliminating intracanal contaminations and preventing bacterial attachment to surfaces are new strategies in this field. This study aimed to evaluate the effect of intracanal
medicines, including calcium hydroxide (CH), zinc oxide nanoparticles (nZnO), pantoprazole (PP), and chlorhexidine (CHX) on Enterococcus faecalis (E. faecalis) in the individual and combinatorial form in an in vitro design in order to introduce an effective medicine for the eradication of
E. faecalis. Sterilized water and sodium hypochlorite (NaOCl) 5.25% were used as the negative
and positive control of antimicrobial activity, respectively.

Methods:
E. faecalis (ATCC 29212) was used for bacterial assays. The powder and the gel forms
of the tested compounds were used in the analysis. The antibacterial and antibiofilm activities of
the medicines were evaluated by the Minimum Inhibitory Concentration (MIC) determination using the broth microdilution method. The anti-biofilm effect of the tested compounds was assessed
by Minimum Biofilm Inhibitory Concentration (MBIC). The antibacterial and antibiofilm effects
of antimicrobial agent combinations were detected using the checkerboard assay and determination of the Fractional Inhibitory Concentration Index (FICI). Time-kill kinetics were conducted at
zero, 2, 4, 6, 8, 10, 12, and 24 h.

Results:
Except for the MIC of the NaOCl, which was significantly lower than CH, there was no
statistically significant difference between groups in MIC and MBIC. Only the mixture of CHX
and nZnO and the mixture of PP and nZnO had a synergic effect against the planktonic and biofilm form of E. faecalis. Except for CHX and ZnO nanoparticles in gel form, other medicines did
not show significant anti-biofilm effects against E. faecalis. Furthermore, the gel for CHX and
nZnO showed stronger anti-biofilm effects.

Conclusion:
Combination therapy of common intracanal medicines with zinc oxide nanoparticles
would lead to higher antibacterial and anti-biofilm effects against E. faecalis compared to conventional intracanal medicaments.
Vitamin E Supplementation to Quail (Coturnix-coturnix Japonica) Treated by Heat Stress: Effects on Blood Hematology Parameters
Authors: Astuti Farida Kusuma , Rinanti Rosyida Fajri , Nurul Mohamad , Tribudi Yuli Arif 
Published: September 2024

Heat stress is a major problem in poultry farming. Environmental temperature and humidity greatly in fluence the performance of poultry, especially quails raised in tropical environments. Vitamin E is a fat-soluble vitamin that has an antioxidant effect. This study aimed to evaluate the effect of vitamin E supplementation on the blood profile of quails kept under heat stress. This study used 4 treatments of T0 as Control (Commercial Feed + Heat Stress 35 oC); T1 (Control + 100 mg of vitamin E/kg); T2 (Control + 150 mg of vitamin E/kg) and T3 (Control + 200 mg of vitamin E/kg). Observed parameters of leukocytes, heterophylls, lymphocytes and monocytes. The data was analyzed by Analysis of Variant (ANOVA) if there were differences between treatments, followed by the Duncan test. The observation results showed that the addition of vitamin E could increase the number of leukocytes, lymphocytes, monocytes and reduce the number of heterophytes and the H/L ratio of quail blood that experienced heat stroke. Based on the blood profile, the addition of vitamin E as much as 200 mg/kg in feed is able to reduce heat stress due to heat stress in laying quails.
Results of a Digital Multimodal Motivational and Educational Program as Follow-Up Care for Former Cardiac Rehabilitation Patients: Randomized Controlled Trial
Authors: Bretschneider Maxi Pia , Mayer-Berger Wolfgang , Weine Jens , Roth Lena , Schwarz Peter E H , Petermann Franz 
Published: September 2024

Abstract

Background
Digital interventions are promising additions for both usual care and rehabilitation. Evidence and studies for the latter, however, are still rare.

Objective
The aim of the study was to examine the app/web-based patient education program called “mebix” (previously called “Vision 2 – Gesundes Herz”) regarding its effectiveness in relation to the parameters of disease-specific quality of life (HeartQoL), cardiovascular risk profile (Cardiovascular Risk Management [CARRISMA]), and prognostic estimation of early retirement (Screening instrument work and occupation [SIBAR]) in 190 participants from a cardiological rehabilitation clinic.

Methods
To evaluate mebix, 354 patients from the Roderbirken Clinic of the German Pension Insurance Rhineland (Germany) with a coronary heart diesase were recruited and randomized either to the intervention group (using mebix postrehabiliation for up to 12 months) or the control group (receiving standard care). The data collection took place at the end of inpatient rehabilitation (t0), as well as 6 months (t1) and 12 months (t2) after the end of rehabilitation. Analyses of variance are used to assess the overall significance of difference in outcome parameters between groups and over time.

Results
The primary endpoint of disease-related quality of life shows a significant improvement of 7.35 points over the course of the intervention that is also more pronounced in the intervention group. Similarly, the 10-year risk of cardiovascular death and myocardial infarction showed significant improvements in the cardiovascular risk profile over time and between groups, indicating better results in the intervention group (ie, a reduction of −1.59 and −5.03, respectively). Positive effects on secondary outcomes like body weight, blood pressure, and number of smokers only showed time effects, indicating no difference between the groups. In addition, the SIBAR was significantly lower/better at the end of the observation period than at the beginning of the observation for both groups.

Conclusions
Overall, the digital training program represents an effective follow-up offer after rehabilitation that could be incorporated into standard care to further improve disease-related quality of life and cardiovascular risk profiles.
Effect of Addition of Metal Oxide Nanoparticles on the Strength of Heat-Cured Denture Base Resins: Protocol for Systematic Review and Meta-Analysis of In Vitro Studies
Authors: Kaurani Pragati , Hindocha Amit , Porwal Amit , Tambe Abhijit , Price Carrie , Goel Vidhani , Krasner Henry , Khubchandani Jagdish , Batra Kavita 
Published: September 2024

Background
Metal oxide nanoparticle–reinforced polymethyl methacrylate (PMMA) has been shown to improve mechanical properties, such as strength. Different types of metal oxide nanoparticles have been used previously, but the comparative effect on the strength of heat-cured denture base resins remains unclear.

Objective
This is a protocol for a systematic review and meta-analysis that will aim to pool evidence to compare and analyze the effects of the addition of different metal oxide nanoparticles, with varied sizes and concentrations, on the strength (flexural, impact, transverse, compressive tensile strength, and fracture toughness) of heat-cured PMMA. In addition, this review aims to analyze methodological factors, such as adherence to testing and sample-making guidelines, and the effects of surface treatments of the nanoparticles on the strength of heat-cured denture base resins.

Methods
The protocol has been registered in the Open Science Framework. Search strategies to identify studies on the effect of metal oxide nanoparticles on the strength of heat-cured PMMA were developed by the subject matter expert in library science. Following this, a systematic search of 5 electronic databases (PubMed [NCBI], Scopus [Elsevier], Cochrane Library [Wiley], CINAHL Plus with Full Text [EBSCO], and Dimensions Free Web App) was conducted to retrieve in vitro studies published in English from January 2012 to October 2023. Along with this citation chasing, other online sources and gray literature were also searched. Furthermore, papers will be screened, and appropriate data elements will be extracted in a standardized manner. A risk-of-bias assessment will be performed using a modified Cochrane Risk of Bias Tool. A meta-analysis will be performed using a random-effects model.

Results
Search in databases resulted in 1837 papers, of which 1752 were duplicates, leaving 85 records that were screened for titles and abstracts based on the eligibility criteria. A similar search run on other online sources identified 129 papers that will be further analyzed for inclusion. The study was initiated in November 2023 and research questions and search strategies were formulated. The proposed study is expected to be completed by December 2024.

Conclusions
This systematic review will comprehensively analyze the effects of the incorporation of metal oxide nanoparticles in heat-cured denture base resins on the strength of the material. We anticipate gaining a deeper understanding of the effects and method of use of metal oxide nanoparticles to improve the strength of PMMA denture base resins.

International Registered Report Identifier (IRRID)
PRR1-10.2196/59999
Protein dan vitamin D3 meningkatkan kadar fosfor maksila anak tikus putih Rattus novergicus galur Wistar dengan berat badan lahir rendah
Authors: Hidayah Rizki Amalia , Huriyati Emy , Hanindriyo Lisdrianto 
Published: September 2024

Protein and vitamin D3 increase the phosphorus levels of maxillary in malnourished mice pupBackground: Protein deficiency during pregnancy leads to malnutrition in the newborn. One of the signs is low birth weight, which impacts bone and teeth growth problems, most probably related to vitamin D and phosphorus deficiency. Adequate protein and vitamin D3 during the nursing period increase the phosphorus level of bone related to fosfor absorption, which increases in the gut.Objective: This research was conducted to determine the effect of protein and vitamin D3 during the nursing period on increasing phosphorus levels of maxillary in prenatal malnutrition mice.Methods: Experimental study with post-test-only control group design. Thirty the Rattus novergicus Wistar strain mice were divided into five groups (n=6). The positive control group (healthy mice suckle in mother who received a standard protein diet and vitamin D3 0.36 IU/g BW/day/oral), negative control group (malnourished mice suckle in mother who received a low protein diet), and three groups of malnutrition mice suckle in mother who receives intervention standard protein diet with vitamin D3 0.36 IU/g BW/day/oral, low protein diet with vitamin D3 0,36 IU/g BW/day/oral, and a standard protein diet without vitamin D3. The parameter measured was phosphorus levels in the maxillary.Results: ANOVA test results showed significant phosphorus level differences of maxillary between groups (p<0.001), and the Post Hoc test showed differences between the control group with interventions 1, 2, and 3 groups.Conclusion: Intervention of a standard protein diet without vitamin D3 or a low protein diet with vitamin D3 0.36 IU/day/oral significantly increases the phosphorus level of maxillary in malnourished mice. However, combining a standard protein diet and vitamin D3 0.36 IU/day/oral is the most optimum for improving maxillary bone phosphorus levels in malnourished mice.
Remoción de metales pesados en agua empleando bioadsorbentes magnéticos
Authors: Guerra Hernández Julia , Espinoza Jarrin Johana 
Published: September 2024

En este trabajo se realizó la síntesis, caracterización y aplicación de un bioadsorbente de pectina – magnetita con propiedades magnéticas para remover metales pesados en soluciones acuosas. Se utilizaron hojas de Áloe Vera como fuente de pectina y se incorporaron nanopartículas de magnetita a través del método de coprecipitación; el material se caracterizó mediante las técnicas de FTIR, DRX y MEB. Se estimó la capacidad máxima de adsorción para los iones Plomo (II) y Cromo (VI) a través de isotermas de adsorción; se obtuvieron 36,442 mg Pb/g y 2,254 mg Cr/g, lo cual indica una mayor afinidad por parte del bioadsorbente hacia el Plomo (II). Se evaluó la remoción de Plomo (II) en un adsorbedor empacado con lecho fresco y reutilizado en presencia de un campo magnético externo; se obtuvieron capacidades de adsorción de 9,6 mg/g y 5,3 mg/g, respectivamente. Las propiedades magnéticas del material permitieron modificar los esquemas evaluados para proponer nuevos arreglos y comparar su eficiencia en términos de capacidad de adsorción y dimensiones. Los esquemas más eficientes fueron la columna empacada y el tubo recubierto (WCOT); en este último se dispuso el adsorbente de forma anular sobre una pared recubierta.
El agroturismo como alternativa comunitaria para el rescate de la zona Alto Andina e histórica de Tacines, Nariño - Colombia
Authors: Delgado-Vargas Iván A. , Cadena Pastrana Álvaro Mauricio , Luna-Cabrera Gloria Cristina , Escobar Pachajoa Laura Dayana , Moreno Villota Mario Erick 
Published: September 2024

La ruta histórica de Tacines, está ubicada entre los municipios de Buesaco y Pasto, departamento de Nariño, Colombia. Lugar donde se evidencia un valioso patrimonio natural e histórico para la región alto andina. Sin embargo, no presenta un aprovechamiento sostenible. El objetivo fue evaluar el potencial agroturístico del territorio enfocado al desarrollo local, mediante el proceso metodológico de caracterización, tipificación de fincas, el diagnóstico y diseño participativo orientado a alternativas agroturísticas. Se evidenció fortalezas en cuanto a tenencia propia, mano de obra familiar y presencia de agrobiodiversidad como aporte a la propuesta agroturística en el territorio. Se clasificaron cuatro tipologías de finca: Restauración ecológica y establecimiento de reservas de la sociedad civil (fincas tipo 1); sistemas silvopastoriles para contribuir a la oferta forrajera de producción sostenible agropecuaria (fincas tipo 2); huertos mixtos (fincas tipo 3); y sistemas de agricultura vertical (fincas tipo 4). Se concluye que la zona de estudio posee unpotencial agroturístico, resaltando la valoración positiva comunitaria y su integración a elementos culturales e históricos, para la implementación de alternativas agropecuarias sostenibles para el desarrollo local del territorio, contribuyendo al valor paisajístico de la zona altoandina, fundamentado en el patrimonio natural de su biodiversidad.
POLÍTICAS DE SAÚDE MENTAL NO TRATAMENTO DO USO E ABUSO DE DROGAS: UMA ANÁLISE COMPARATIVA ENTRE BRASIL E FRANÇA
Authors: Bonaldo Pedro Martini , Amparo Deise Matos do , Lignier Baptiste , Bonaldo Mariana Lima Martini , Roques Marjorie 
Published: September 2024

Este artigo buscou realizar uma análise comparativa das políticas de saúde mental para o uso de álcool e outras drogas no Brasil e na França, apresentando assim os principais aspectos históricos, legais, convergências e divergências entre esses sistemas de saúde pública. Primeiramente foram introduzidos os aspectos históricos da política de saúde mental no Brasil aplicados a toxicologia e posteriormente, foram discutidos os dispositivos de cuidado utilizados nos CAPS. Além disso, foi apresentado o modelo de tratamento francês de saúde mental para pessoas com problemas com álcool e outras drogas. A metodologia utilizada foi a revisão temática da literatura, com enfoque nas contribuições de documentos públicos sobre as principais estratégias no tratamento da toxicomania no Brasil e França e na literatura sobre saúde mental e psicanálise referente ao tema. O critério de seleção da bibliografia nacional e internacional, foi baseado na relevância temática e aplicabilidade do tema. Como principais resultados indicamos que tanto no Brasil quanto na França existe uma competição entre duas vertentes de tratamentos: a abstinência com a pretensão que o usuário de drogas pare de usar totalmente qualquer substância e a redução de danos com objetivo de convencer o dependente a diminuir gradualmente seu consumo de substâncias. Outros resultados apontam a diferença entre a perspectiva brasileira e francesa como, por exemplo, a presença central do hospital psiquiátrico no sistema francês, dispositivo este ausente no Brasil devido a Reforma Psiquiátrica brasileira. Conclui-se que ambos os sistemas apresentam desafios na integração entre as políticas públicas e os serviços de saúde.
ASEAN Countries on Overcoming US – China Trade War
Authors: Zuliyan Muhammad Arief , Alfian Muhammad Faizal 
Published: September 2024

The trade war between the United States and China mostly has a negative impact to foreign policy in Indo-Pacific Region, included ASEAN countries. The US-China Trade war absolutely hamper ASEAN economicallyThe ASEAN nations are dealing with China-US relations as two great power states are taking big important role economically in ASEAN. This work is aim to question how ASEAN takes action from this situation to overcome the impact of Trade war and by using Neoliberalism, the paper would like to show the strategy ‘flexibility in interdependence’ which explains how the ASEAN economic integration could mitigate the problems and reducing the tensions using liberal interdependence. We conclude the flexibility in interdependence is based on two trade instrument including Generalized System Preference (GSP) and Regional Comprehensive Economic Forum (RCEP).
Islamisme, Melayu Muslim, dan Revivalisme Islam di Asia Tenggara
Authors: Karim Syahrir 
Published: September 2024

Dalam artikel ini akan berusaha membincangkan Islam dan Melayu serta hubungan dengan arus kebangkitan Islam. Selanjutnya akan dibahas wacana identitas Melayu Islam yang sering menjadi topik perbahasan di kalangan intelektual khususnya Melayu Islam. Di masa lalau, boleh dikatakan bawa peradaban Islam kelihatan di Timur Tengah dan eropa, maka di era globalisasi saatini banyak yang meyakini bahwakebangkitan Islam akan terbit dari Asia Tenggara. Indonesia dan Malaysia menjadi bahagian terpenting yangberpotensi untuk memimpin dunia baru Islam. Di abad moderen ini tidak ada lagi optimisme bahwa TimurTengah apalagi Eropah akan mampu mempertahankan kegemilangan peradaban yang pernah ditorehkan dipentas sejarah. Fenomena Islamisme akan semakin menegaskan identitas masyarakat Islam sebagai sebuahkekuatan politik, ekonomi bahkan teknologi di Asia Tenggara. Gerakan-gerakan Islam yang berbentukrevivalisme Islam dilihat semakin memperlihatkan warna Islam yang jauh lebih multireligius, multikultural, moderat, dan pluralistik yang menjunjung nilai-nilai demokrasi.
The Dynamics Model of Cross-Regional to Enhance Economic Growth: New Empirical Evidence from Indonesia
Authors: Badriah Lilis Siti , Arintoko  
Published: September 2024

Abstract
Economic growth growth is crucial to improve community welfare in the long term. Although Indonesia’s economic growth is on an upward trend, Indonesia must remain vigilant in its relationship with the global world due to the rapidly changing and highly uncertain dynamics. Indonesia’s economic growth is also inseparable from the influence of various provinces’ economic growth, which varies due to the economic dynamics between regions. These dynamics can influence the region’s contribution to national economic growth. Therefore, identifying the important role of the determining factors of economic growth and appropriate policies in dealing with economic dynamics between regions is crucial because sustainable economic growth is also essential for improving community welfare. This study examines the determinants of Indonesia’s economic growth from a regional economic perspective, using a Dynamic Panel Data analysis model with three estimation models. The first model focuses on the primary variables of technological progress, population, and investment. The second model adds the human capital variable, while the third model further incorporates the variables of open economy, economic structure changes, and income inequality. The study utilizes data from the Indonesian Central Statistics Agency, covering 27 provinces from 2015 to 2022. The results indicate that increased technological progress, population, investment, human resources, economic openness, and economic structure changes can increase economic growth, while inequality of income harms economic growth. This research has implications that in creating determinant conditions for conducive economic growth, it needs to be carried out evenly in all provinces in Indonesia.
Individual determinants of job satisfaction among young adults in Poland
Authors: Śliwicki Dominik , Szczepaniak Małgorzata , Szulc-Obłoza Agnieszka 
Published: September 2024

Abstract
Job satisfaction is an essential factor influencing employees as well as employers. This study aims to identify and compare overall job satisfaction determinants among young adults in Poland in two dimensions, i.e., economic and socio-demographic. The ordered logit model was built upon the data collected in 2021 in a survey using the Computer Assisted Web Interview technique on a sample of 304 young adults aged 18–29 years in Poland. The results indicate that young adults’ job satisfaction in Poland is determined by wage satisfaction to the highest extent. It was also demonstrated that the impact of economic factors on job satisfaction is much stronger than that of socio-demographic ones. Individual income increases the probability of high job satisfaction to a greater extent than disposable income per person in a household. Moreover, the economic profile of education increases the probability of greater job satisfaction.
Negociações tensas: análise neuropsicológica e jurídica do fator raiva nas negociações
Authors: Pinto Moreira Denis Gleyce 
Published: September 2024

O presente artigo pretende examinar os múltiplos aspectos do fator emocional raiva em negociações tensas. Trata-se de análise neuropsicológica e jurídica deste fator em negociações e suas repercussões emocionais, cognitivas, relacionais e jurídicas. O estudo também trata da tomada de decisão e abrange contribuições da filosofia, psicologia, neurociência, economia comportamental e esclarece aspectos positivos e negativos da raiva, inclusive em negociações que fazem parte da dinâmica de resolução de conflitos.