bluuebunny/crossref_metadata_2025_split huggingface dataset:
New age constraints for the limit of the British–Irish Ice Sheet on the Isles of Scilly
Authors: Smedley R. K. , Scourse J. D. , Small D. , Hiemstra J. F. , Duller G. A. T. , Bateman M. D. , Burke M. J. , Chiverrell R. C. , Clark C. D. , Davies S. M. , Fabel D. , Gheorghiu D. M. , McCarroll D. , Medialdea A. , Xu S. 
Published: January 2017

ABSTRACTThe southernmost terrestrial extent of the Irish Sea Ice Stream (ISIS), which drained a large proportion of the last British–Irish Ice Sheet, impinged on to the Isles of Scilly during Marine Isotope Stage 2. However, the age of this ice limit has been contested and the interpretation that this occurred during the Last Glacial Maximum (LGM) remains controversial. This study reports new ages using optically stimulated luminescence (OSL) dating of outwash sediments at Battery, Tresco (25.5 ± 1.5 ka), and terrestrial cosmogenic nuclide exposure dating of boulders overlying till on Scilly Rock (25.9 ± 1.6 ka), which confirm that the ISIS reached the Isles of Scilly during the LGM. The ages demonstrate this ice advance on to the northern Isles of Scilly occurred at ∼26 ka around the time of increased ice‐rafted debris in the adjacent marine record from the continental margin, which coincided with Heinrich Event 2 at ∼24 ka. OSL dating (19.6 ± 1.5 ka) of the post‐glacial Hell Bay Gravel at Battery suggests there was then an ∼5‐ka delay between primary deposition and aeolian reworking of the glacigenic sediment, during a time when the ISIS ice front was oscillating on and around the Llŷn Peninsula, ∼390 km to the north. Copyright © 2017 The Authors. Journal of Quaternary Science Published by John Wiley & Sons, Ltd.
The sedimentary history of the inner‐alpine Inn Valley, Austria: extending the Baumkirchen type section further back in time with new drilling
Authors: Barrett Samuel , Starnberger Reinhard , Tjallingii Rik , Brauer Achim , Spötl Christoph 
Published: January 2017

ABSTRACTThe Baumkirchen clay pit near Innsbruck, western Austria, is a well‐known site in Alpine Quaternary stratigraphy. Lacustrine sediments from the last glacial cycle from within the Alps provide a unique opportunity to investigate the regional palaeoclimate. Recent drilling has extended the known sequence to a total length of at least 250 m consisting of almost entirely well‐laminated clayey silt. Luminescence dating identified two lake sequences, separated by a hiatus of ca. 7000–15 000 years. Lake phase 1 spans the period ca. 77–55 ka, i.e. from about Marine Isotope Stage (MIS) 5/4 to the MIS 4/3 transition. Lake phase 2 extends from mid‐ to late MIS 3 between ca. 45 and 33 ka. Down‐core X‐ray fluorescence core scanning confirmed the presence of the lake phases in the sediment composition, suggesting different sediment sources and/or transport mechanisms during these two intervals. A unique section of exotic, angular, silt matrix‐supported gravel at the top of lake phase 1 is interpreted as ice‐rafted debris. Luminescence dating constrains this layer to ca. 55 ka, thus providing the first evidence of a late MIS 4 or early MIS 3 ice advance confined to the interior of the Eastern Alps. A conceptual model of the sedimentary history of the valley is presented.
The role of oncoplastic breast reduction in the conservative management of breast cancer: Complications, survival, and quality of life
Authors: Acea‐Nebril Benigno , Cereijo‐Garea Carmen , García‐Novoa Alejandra , Varela‐Lamas Cristina , Builes‐Ramírez Sergio , Bouzón‐Alejandro Alberto , Mosquera‐Oses Joaquín 
Published: January 2017

Background and ObjectivesReduction Mammaplasty (RM) in breast cancer allows mammary remodeling after wide excisions. We aimed to analyze the complications, survival, and quality of life after RM.MethodsRetrospective study of women who underwent a surgical intervention for breast cancer between 2000 and 2016. Patients were divided into two groups: RM and tumorectomy. Postoperative complications, survival and quality of life were assessed using the Breast‐Q questionnaire.ResultsA total of 801 patients were evaluated, with a mean follow up of 84 months. RM patients experienced a longer operating time and hospital stay, and a higher proportion of tissue necrosis compared to tumorectomy patients (P < 0.001). No significant differences were observed regarding rate of re‐excision or rate of mastectomy, but the recurrence rate at 10 years was higher for RM patients (P < 0.03). Patients who underwent RM reported optimal satisfaction with the breast and a good quality of life.ConclusionsRM is a useful approach in breast cancer surgery, with a low rate of re‐excision and mastectomy. Overall survival at 10 years is similar to that associated with tumorectomy, though with a higher rate of local recurrence. Patient satisfaction and quality of life appears to be good one year after radiotherapy.
Post‐mastectomy radiation therapy and overall survival after neoadjuvant chemotherapy
Authors: Kantor Olga , Pesce Catherine , Singh Puneet , Miller Megan , Tseng Jennifer , Wang Chi‐Hsiung , Winchester David J. , Yao Katharine 
Published: January 2017

BackgroundThe role of postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) and mastectomy is unclear, especially in patients that have post‐treatment tumor negative axillary nodes (ypN0).MethodsThe National Cancer Data Base was used to identify women that had PMRT after NAC and mastectomy for clinically node positive (cN1‐2) disease from 2004 to 2008. Median follow‐up time was 69 months.Results8,321 patients were included for analysis, and 6140 (65.6%) had cN1 disease and 2181 (23.3%) had cN2 disease. On adjusted survival analysis, PMRT was associated with an overall survival (OS) benefit in both patients with cN1 (5‐yr OS 75.8% vs. 71.9%, P < 0.01) and cN2 (5‐yr OS 69.2% vs. 58.6%, P < 0.01) disease. In the subgroup of patients that were ypN0 after NAC, there was no significant survival difference (P > 0.11) for PMRT compared to those patients who were not ypN0, except for patients with hormone‐receptor negative tumors, who had improved OS with PMRT (HR 0.65, P < 0.01).ConclusionsPMRT is associated with improved OS in patients with cN1 and cN2 disease after NAC and mastectomy. However, in the subgroup of patients that were ypN0 after NAC, PMRT improved OS for hormone‐receptor negative patients but not hormone‐receptor positive patients.
Unpacking Directions and Spatial Patterns of VFR Travel Mobilities in the Global South: Insights from South Africa
Authors: Rogerson Christian M. 
Published: January 2017

AbstractUnpacking the spatial patterns of visiting friends and relatives (VFR) mobilities within (and between) countries represents an investigatory void in existing international VFR scholarship. The paper seeks to interrogate the relationships between historical and contemporary migration flows and VFR travel by using the case of South Africa. The study highlights the importance of understanding the role of multi‐locational households, the roots and persistence of circulatory migration flows and their manifestations in the present‐day geography of VFR travel mobilities in post‐apartheid South Africa. Interpreting the changing spatial patterns of VFR travel must be grounded in the historical and contemporary dynamics of local and regional migration systems. For South Africa's poorest areas where VFR travel flows are the dominant if sometimes the only form of tourism, policy issues arise for leveraging this form of tourism for enhancing local development. Copyright © 2017 John Wiley & Sons, Ltd.
Acceptance of Smartphone‐Based Mobile Shopping: Mobile Benefits, Customer Characteristics, Perceived Risks, and the Impact of Application Context
Authors: Hubert Marco , Blut Markus , Brock Christian , Backhaus Christof , Eberhardt Tim 
Published: January 2017

ABSTRACTDespite their generally increasing use, the adoption of mobile shopping applications often differs across purchase contexts. In order to advance our understanding of smartphone‐based mobile shopping acceptance, this study integrates and extends existing approaches from technology acceptance literature by examining two previously underexplored aspects. First, the study examines the impact of different mobile and personal benefits (instant connectivity, contextual value, and hedonic motivation), customer characteristics (habit), and risk facets (financial, performance, and security risk) as antecedents of mobile shopping acceptance. Second, it is assumed that several acceptance drivers differ in relevance subject to the perception of three mobile shopping characteristics (location sensitivity, time criticality, and extent of control), while other drivers are assumed to matter independent of the context. Based on a dataset of 410 smartphone shoppers, empirical results demonstrate that several acceptance predictors are associated with ease of use and usefulness, which in turn affect intentional and behavioral outcomes. Furthermore, the extent to which risks and benefits impact ease of use and usefulness is influenced by the three contextual characteristics. From a managerial perspective, results show which factors to consider in the development of mobile shopping applications and in which different application contexts they matter.
Effects of Blue Lighting in Ambient and Mobile Settings on the Intention to Buy Hedonic and Utilitarian Products
Authors: Guido Gianluigi , Piper Luigi , Prete M. Irene , Mileti Antonio , Trisolini Carla M. 
Published: January 2017

ABSTRACTAccording to multidisciplinary research, the blue light has important consequences for human beings’ productivity and well‐being, as it positively influences their circadian, endocrine, and neurobehavioral functions. This paper examines how blue light—in both the physical environment and a mobile display—influences consumers’ purchase intentions in mobile shopping. Specifically, this paper proposes that consumers who are exposed to certain conditions of blue lighting (identified by an emission spectrum centered at 460 nm; i.e., “actinic blue”), in either a room environment or via a smartphone, are more inclined to purchase hedonic rather than utilitarian products. After describing the study, which compares the effects of blue lighting to more traditional white lighting (identified with an emission spectrum centered at 635 nm; i.e., “warm white”), the paper discusses results, alongside the implications for theory, marketing practice, and future research.
Neoagarotetraose protects mice against intense exercise‐induced fatigue damage by modulating gut microbial composition and function
Authors: Zhang Na , Mao Xiangzhao , Li Robert W. , Hou Enling , Wang Yuming , Xue Changhu , Tang Qingjuan 
Published: January 2017

ScopeExhaustive exercise stress has emerged as an important health issue, and gastrointestinal problems are a common concern during intense exercise. In this study, we investigated the potential antifatigue effects of neoagarotetraose (NAT) in mice under intense exercise stress.Materials and methodsExhaustive exercise stress significantly weakened several physiological and physical parameters of the mice, including decreased food intake, reduced body weight, and impaired integrity of the intestinal epithelial barrier. Our data showed that a 16‐day NAT treatment resulted in a profound change in microbiome composition, which subsequently led to widespread shifts in the functional potential of the gut microbiome. Furthermore, NAT administration significantly increased the fecal concentration of total short‐chain fatty acids (p < 0.01).ConclusionTogether, our findings suggest that NAT may protect mice against intense exercise‐induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.
Propacetamol poses a potential harm of adverse hypotension in male and older patients
Authors: Lee Hyun‐Young , Ban Ga‐Young , Jeong Chang‐Gyu , Lee Ji‐Ho , Park Seung‐Hee , Kim Sang‐Hee , Lee Young‐Hee , Ye Young‐Min 
Published: January 2017

AbstractPurposeResearchers recently suggested intravenous paracetamol as a potential cause of hypotension. We aimed to investigate risk factors of paracetamol‐ and propacetamol‐associated adverse drug reactions (ADRs) in Korean individuals.MethodsAll adverse hypotension cases, regardless of suspected drug, and all ADRs associated with paracetamol and propacetamol use were collected from the Korea Adverse Event Reporting System database between 2011 and 2014. The seriousness, causality, and type of ADR were classified.ResultsOf 4,771 cases of adverse hypotension, 403 (8.4%) were reported to be related to propacetamol. This was comparable to the rate of hypotension associated with fentanyl (454, 9.5%), the major suspected drug of hypotension. Paracetamol‐associated hypotension accounted for merely 1.2% (55 cases) of all hypotension cases. Among ADRs associated with propacetamol use, hypotension was the most common (37.1%), whereas cutaneous reactions were the primary paracetamol‐associated ADR. Propacetamol/paracetamol‐associated hypotension was frequently recorded in older patients (≥54 years) (53.9 ± 25.8 vs. 42.8 ± 21.7, P < 0.001) and taking more concomitant drugs (1.9 ± 5.0 vs. 1.1 ± 3.2, P < 0.001). Also, compared with other ADRs associated by propacetamol/paracetamol, hypotension was more commonly assessed as a serious outcome (27.3% vs. 11.4%, P < 0.001). Regarding concomitant medications, the risk for hypotension associated with propacetamol was significantly increased in patients simultaneously taking antibacterials (J01), cold preparations (R05), drugs for acid related disorders (A02), blood substitutes (B05), or antithrombotics (B01).ConclusionsPropacetamol was found to be a major suspected drug of pharmacologically associated hypotension in Korea. Older and male patients taking medications in combination with propacetamol/paracetamol should undergo monitoring of their blood pressure. Copyright © 2017 John Wiley & Sons, Ltd.
Risk of Mortality in Elderly Nursing Home Patients with Depression Using Paroxetine
Authors: Bali Vishal , Chatterjee Satabdi , Johnson Michael L. , Chen Hua , Carnahan Ryan M. , Aparasu Rajender R. 
Published: January 2017

ObjectiveAmong selective serotonin reuptake inhibitors (SSRIs), paroxetine is strongly anticholinergic and might lead to a higher risk of adverse outcomes such as mortality. This study examined the risk of mortality in depressed elderly nursing home patients using paroxetine and other SSRIs.MethodsThis study used 2007–2010 Minimum Data Set–linked Medicare data and a propensity score (PS)‐matched retrospective cohort study design to achieve the study objective. New users of paroxetine and other SSRIs were followed until they reached the end of the follow‐up period (1 year), switched to a different antidepressant class, used psychotherapy, or had a gap of more than 15 days in the use of index antidepressant class, whichever occurred earlier. A robust Cox proportional hazard (PH) model was used to evaluate the risk of mortality associated with the use of paroxetine and other SSRIs in depressed elderly nursing home residents.ResultsThe PS matching yielded 4620 patients each in the two treatment groups. The unadjusted incidence of mortality was 269 (2.9%) for paroxetine and 288 (3.1%) for other SSRIs users in the matched cohort. The robust Cox PH model did not find any significant difference in the risk mortality between the two groups (hazard ratio 1.01; 95% confidence interval 0.86–1.19).ConclusionsThis study did not find any significant difference in the risk of mortality between users of paroxetine and other SSRIs among elderly nursing home patients with depression. There is a need for further evaluation of other adverse effects of paroxetine due to its anticholinergic effects in the geriatric population.
Aggregation‐Induced Emission for Highly Selective and Sensitive Fluorescent Biosensing and Cell Imaging
Authors: Huang Liang , Dai Liming 
Published: January 2017

ABSTRACTFluorescent bioprobes are powerful analytical tools for studying biological activities in living systems. Fluorogens with aggregation‐induced emission (AIE) characteristics have recently emerged as a new class of fluorescent bioprobes for biosensing and cell imaging. As discovered by Tang, AIE fluorogens are nearly nonemissive in molecular states with their intermolecular rotations being not restricted whereas their fluorescence is turned on by binding with certain biomolecules, leading to highly selective turn‐on fluorescent probes for specific biomolecules and fluorescent cell imaging with a high signal‐to‐background noise ratio. By introducing the AIE characteristics into polymeric materials, AIE polymers could possess a good solubility and biocompatibility, excellent structural diversity, and ease for functionalization useful for efficient biosensing and cell imaging. Herein, we highlight a few recently published articles on small and macromolecular AIE molecules to provide a fundamental understanding of the AIE mechanism and illustrate the working principle for AIE based biosensing and cell imaging. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 653–659
An Improved Process Towards Hexahydro‐1,3,5‐trinitroso‐1,3,5‐triazine (TNX)
Authors: Rothstein Sarah A. , Dubé Pascal , Anderson Stephen R. 
Published: January 2017

AbstractHexahydro‐1,3,5‐trinitroso‐1,3,5‐triazine (TNX) is mostly known as a by‐product in the environmental decomposition of RDX. The original chemistry to TNX was never optimized and thus resulted in low yields due to competitive degradation of the starting material. Enabled conditions to TNX were developed by optimizing pH effects and mitigating foaming by reactor geometry and stirring. The conditions presented herein allow for the inexpensive and simple production of multi‐gram quantities of TNX. The isolated TNX obtained by our new method was characterized by 1H NMR, 13C NMR, DSC, and X‐ray crystallography. A preliminary evaluation of the sensitivity of TNX towards impact and friction is also presented.
Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex
Authors: Bandyopadhyay Nirmalya , Das Mousumi , Samanta Amalesh , Zhu Miaoli , Lu Liping , Naskar Jnan Prakash 
Published: January 2017

AbstractThis work delineates with the development of a novel oxime based palladium complex as a promising antimicrobial agent. A novel oxime based ligand, 3‐[(2‐hydroxy‐naphthalen‐1‐ylmethylene)‐hydrazono]‐butan‐2‐one oxime (LH), has been employed to synthesize an orange, monomeric, diamagnetic palladium(II) compound, [Pd(L)(Cl)] (1) in moderate yield. LH is a mono‐condensate Schiff‐base of 2,3‐butanedionemonoxime monohydrazone and 2‐hydroxy‐1‐naphthaldehyde in tetrahydrofuran. Both the ligand and its palladium compound have been characterized by spectroscopic and analytical techniques. The X‐ray crystal structure of 1 reveals that the palladium center in [Pd(L)(Cl)] is nested in a distorted square‐planar ‘N2OCl’ coordination environment. The electrochemical behavior of [Pd(L)(Cl)] in DMF shows a Pd(II)/ Pd(I) irreversible reduction couple. The in vitro antibacterial activity of [Pd(L)(Cl)] was tested against a good number of human pathogenic Gram‐positive and Gram‐negative bacterial cell lines. The in vitro antifungal activity of the titled palladium compound was screened against several pathogenic fungal strains. The promising antimicrobial efficacy of the palladium compound was corroborated through SEM study.
N‐Acylbenzotriazole as Efficient Ligand in Copper‐Catalyzed O‐Arylation Leading to Diverse Benzoxazoles
Authors: Singh Anoop S. , Singh Mala , Mishra Nidhi , Mishra Snigdha , Agrahari Anand K. , Tiwari Vinod K. 
Published: January 2017

AbstractAn establishment of (1H‐benzo[d][1,2,3]triazol‐1‐yl)(2‐methoxyphenyl)methanone as ligand was attained in intramolecular C‐O cross‐coupling of N‐(2‐halophenyl)aryl/alkylamide derivatives to form 2‐Aryl/alkyl benzoxazole derivatives using CuI/K2CO3 as catalytic system. A series of benzoxazoles was developed using this protocol and synthesized compounds were characterized using spectroscopic analysis (IR, MS, 1H & 13C NMR). Salient advantages associated with this pathway include easily available starting materials, cheap catalyst, highly stable ligand, wide substrate scope, smooth reaction, easy work‐up and high product yield.
Anticancer Activity and DNA Binding Studies of Novel 3,7‐Disubstituted Benzopyrones
Authors: Durgapal Sunil Dutt , Soni Rina , Umar Shweta , Suresh Balakrishnan , Soman Shubhangi S. 
Published: January 2017

AbstractWe have designed and synthesized novel 7‐substituted‐3‐acetyl‐benzopyrones 9 a‐9 g and ethyl 7‐substituted‐3‐carboxylate‐benzopyrones 10 a‐10 d and screened for anticancer activity using MTT assay. Most of the tested compounds have shown very good activity against A549 cell line (lung cancer cell‐line) and MCF7 cell line (breast cancer cell‐line) compared to 5‐Fluorouracil. Compound 9 b and 9 e exhibited excellent anticancer activity with IC50 0.16 nM against A549 cell line and 84.8 nM against MCF7 cell line respectively. Compounds 9 b and 9 e showed excellent anticancer activity at very low concentration, well falling in nanomolar region. Compounds 9 b and 9 e exhibited very good binding constant for DNA binding through intercalation in UV based DNA titration which was further confirmed by fluorescence based EtBr displacement assay in DNA‐EtBr complex.
Symbiotic Interaction of Amalgamated Photocatalysts with Improved Day Light Utilisation and Charge Separation
Authors: Leong Kah Hon , Tan Zhu Zhin , Sim Lan Ching , Saravanan Pichiah , Bahnemann Detlef , Jang Min 
Published: January 2017

AbstractA promising amalgamation of organic with inorganic semiconductor photocatalyst (g‐C3N4/SrTiO3) with varied g‐C3N4 concentration was synthesised through a simple thermal method. The organic semiconductor was prepared through a facile pyrolysis of urea while perovskite (SrTiO3) by sol‐gel hydrothermal route. The observed mechanistic characteristics of the synthesised composite photocatalysts were thoroughly analysed through robust analytical tools. The dissection analysis clearly revealed that amalgamation of organic semiconductor stimulated the utilisation of solar spectrum by enhancing the light absorption towards visible band. Where else perovskite activated close interfacial connections leading to enhanced efficiency of electron migration. The Electron Paramagnetic Resonance (EPR) excited under solar spectrum along with Photoluminescence (PL) clearly indicated the prolongation of the charge carriers. A symbiotic interaction with mutual benefit was clearly observed between these photocatalysts. The solar photocatalysis ability of the perovskite composite was examined by degrading a non‐photosensitising compound (Bisphenol A). The photocatalysis experiment clearly revealed its dominant solar light harvesting capability of the developed perovskite amalgamated organic photocatalyst.