bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network dynamics in the healthy and epileptic developing brain
Authors: Rosch RE , Baldeweg T , Moeller F , Baier G 
Published: May 2017

ABSTRACTElectroencephalography (EEG) allows recording of cortical activity at high temporal resolution. EEG recordings can be summarised along different dimensions using network-level quantitative measures, e.g. channel-to-channel correlation, or band power distributions across channels. These reveal network patterns that unfold over a range of different time scales and can be tracked dynamically.Here we describe the dynamics of network-state transitions in EEG recordings of spontaneous brain activity in normally developing infants and infants with severe early infantile epileptic encephalopathies (n=8, age: 1-8 months). We describe differences in measures of EEG dynamics derived from band power, and correlation-based summaries of network-wide brain activity.We further show that EEGs from different patient groups and controls can be distinguished based on a small set of the novel quantitative measures introduced here, which describe dynamic network state switching. Quantitative measures related to the smoothness of switching from one correlation pattern to another show the largest differences between groups.These findings reveal that the early epileptic encephalopathies are associated with characteristic dynamic features at the network level. Quantitative network-based analyses like the one presented here may in future inform the clinical use of quantitative EEG for diagnosis.
A 1.1-Mb Transcript Map of the Hereditary Hemochromatosis Locus
Authors: Ruddy David A. , Kronmal Gregory S. , Lee Vincent K. , Mintier Gabriel A. , Quintana Leah , Domingo Rodolfo , Meyer Nicole C. , Irrinki Alivelu , McClelland Erin E. , Fullan Amy , Mapa Felipa A. , Moore Theodore , Thomas Winston , Loeb Deborah B. , Harmon Cyrus , Tsuchihashi Zenta , Wolff Roger K. , Schatzman Randall C. , Feder John N. 
Published: May 2017

In the process of positionally cloning a candidate gene responsible for hereditary hemochromatosis (HH), we constructed a 1.1-Mb transcript map of the region of human chromosome 6p that lies 4.5 Mb telomeric toHLA-A. A combination of three gene-finding techniques, direct cDNA selection, exon trapping, and sample sequencing, were used initially for a saturation screening of the 1.1-Mb region for expressed sequence fragments. As genetic analysis further narrowed the HH candidate locus, we sequenced completely 0.25 Mb of genomic DNA as a final measure to identify all genes. Besides the novel MHC class 1-like HH candidate geneHLA-H, we identified a family of five butyrophilin-related sequences, two genes with structural similarity to a type 1 sodium phosphate transporter, 12 novel histone genes, and a gene we namedRoRetbased on its strong similarity to the 52-kDRo/SSAlupus and Sjogren’s syndrome auto-antigen and theRETfinger protein. Several members of the butyrophilin family and theRoRetgene share an exon of common evolutionary origin called B30-2. The B30-2 exon was originally isolated from the HLA class 1 region, yet has apparently “shuffled” into several genes along the chromosome telomeric to the MHC. The conservation of the B30-2 exon in several novel genes and the previously described amino acid homology ofHLA-Hto MHC class 1 molecules provide further support that this gene-rich region of 6p21.3 is related to the MHC. Finally, we performed an analysis of the four approaches for gene finding and conclude that direct selection provides the most effective probes for cDNA screening, and that as much as 30% of ESTs in this 1.1-Mb region may be derived from noncoding genomic DNA.[The sequence data described in this paper have been submitted to GenBank under accession nos.U90543–U90548,U90550–U90552, andU91328.]
The Complex Mutation Pattern of a Microsatellite
Authors: Macaubas Claudia , Jin Li , Hallmayer Joachim , Kimura Akinori , Mignot Emmanuel 
Published: May 2017

DQCARis a (CA)nmicrosatellite located in the HLA class II region and tightly linked toHLA–DQB1. Previous studies showed a strikingly low level of size variation inDQCARalleles within an extensive subfamily ofHLA–DQsubtypes (DQ1).DQCARalleles in non-DQ1subtypes showed a higher degree of size polymorphism. In this study sequence analysis demonstrates thatDQ1- associatedDQCARalleles have a single C → A nucleotide substitution interupting the CA repeat array. Frequent CA → GA mutations are also observed inDQ1-associated microsatellites with identical allele sizes. In contrast,DQCARalleles associated with non-DQ1haplotypes display a perfect CA repeat sequence and the variation in allele size is attributable only to differences in the number of CA repeats. Our results imply that several mutational mechanisms are involved in the generation of allelic diversity within the same microsatellite locus. The possibility of different mutation rates in the same locus should to be taken into account when using these markers in evolutionary and disease studies.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos.U96944–U96962andS87165.]
A Gene Map of the Best’s Vitelliform Macular Dystrophy Region in Chromosome 11q12–q13.1
Authors: Stöhr Heidi , Marquardt Andreas , Rivera Andrea , Cooper Paul R. , Nowak Norma J. , Shows Thomas B. , Gerhard Daniela S. , Weber Bernhard H.F. 
Published: May 2017

Best’s vitelliform macular dystrophy is an autosomal dominant disorder of unknown causes. To identify the underlying gene defect the disease locus has been mapped to an ∼1.4-Mb region on chromosome 11q12–q13.1. As a prerequisite for its positional cloning we have assembled a high coverage PAC contig of the candidate region. Here, we report the construction of a primary transcript map that places a total of 19 genes within the Best’s disease region. This includes 14 transcripts of as yet unknown function obtained by EST mapping and/or cDNA selection and five genes mapped previously to the interval (CD5, PGA, DDB1, FEN1, and FTH1). Northern blot analyses were performed to determine the expression profiles in various human tissues. At least three genes appear to be good candidates for Best’s disease based on their abundant expression in retina or retinal pigment epithelium. Additional information on the functional properties of these genes, as well as mutation analyses in Best’s disease patients, have to await their further characterization.[The GenBank/EMBL accession numbers and details of the isolation, localization, and characterization of ESTs and selected cDNAs are available as online supplements in Online Tables 1–3 at http://www.genome.org.]
Characterization and Comparison of the Human and MouseGLC1A Glaucoma Genes
Authors: Fingert John H. , Ying Lihua , Swiderski Ruth E. , Nystuen Arne M. , Arbour Nancy C. , Alward Wallace L.M. , Sheffield Val C. , Stone Edwin M. 
Published: May 2017

The GLC1A gene (which encodes the protein myocilin) has been associated with the development of primary open angle glaucoma. Bacterial artificial chromosomes containing the human GLC1Agene and its mouse ortholog were subcloned and sequenced to reveal the genomic structure of the genes. Comparison of the coding sequences of the human and mouse GLC1A genes revealed a high degree of amino acid homology (82%) and the presence of several conserved motifs in the predicted GLC1A proteins. The expression of GLC1A was examined by Northern blot analysis of RNA from adult human tissues.GLC1A expression was observed in 17 of 23 tissues tested, suggesting a wider range of expression than was recognized previously. The comparison of the human and mouse GLC1A genes suggests that the mouse may be a useful model organism in studying the molecular pathophysiology of glaucoma.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF049791–AF049796.]
Simultaneous Genotyping and Species Identification Using Hybridization Pattern Recognition Analysis of Generic Mycobacterium DNA Arrays
Authors: Gingeras Thomas R. , Ghandour Ghassan , Wang Eugene , Berno Anthony , Small Peter M. , Drobniewski Francis , Alland David , Desmond Edward , Holodniy Mark , Drenkow Jorg 
Published: May 2017

High-density oligonucleotide arrays can be used to rapidly examine large amounts of DNA sequence in a high throughput manner. An array designed to determine the specific nucleotide sequence of 705 bp of therpoB gene of Mycobacterium tuberculosis accurately detected rifampin resistance associated with mutations of 44 clinical isolates of M. tuberculosis. The nucleotide sequence diversity in 121 Mycobacterial isolates (comprised of 10 species) was examined by both conventional dideoxynucleotide sequencing of the rpoB and 16S genes and by analysis of the rpoB oligonucleotide array hybridization patterns. Species identification for each of the isolates was similar irrespective of whether 16S sequence, rpoBsequence, or the pattern of rpoB hybridization was used. However, for several species, the number of alleles in the 16S andrpoB gene sequences provided discordant estimates of the genetic diversity within a species. In addition to confirming the array’s intended utility for sequencing the region of M. tuberculosis that confers rifampin resistance, this work demonstrates that this array can identify the species of nontuberculous Mycobacteria. This demonstrates the general point that DNA microarrays that sequence important genomic regions (such as drug resistance or pathogenicity islands) can simultaneously identify species and provide some insight into the organism’s population structure.[The sequence data described in this paper have been submitted to GenBank under accession nos. AF09766–AF059853 and AF060279–AF060367.]
Chicken Microchromosomes Are Hyperacetylated, Early Replicating, and Gene Rich
Authors: McQueen Heather A. , Siriaco Giorgia , Bird Adrian P. 
Published: May 2017

The chicken karyotype consists of 39 chromosomes of which 33 are classed as microchromosomes (MICs). MICs contain about one third of genomic DNA. The majority of mapped chicken genes are assigned to macrochromosomes (MACs), but a recent study indicated that CpG islands (CGIs), which are associated with most vertebrate genes, map predominantly to MICs. The present work establishes that chicken genes are concentrated on MICs by several criteria. Acetylated (lysine 5) histone H4, which is strongly correlated with the presence of genes, is highly enriched on MICs by immunocytochemistry. In addition, detailed analysis of chicken cosmids shows that CGI-like fragments are approximately six times denser on MICs than on MACs. Published mapping of randomly chosen genes by fluorescent in situ hybridization (FISH) also shows a significant excess of microchromosomal assignments. Finally, the finding that MICs replicate during the first half of S phase is also compatible with the suggestion that MICs represent gene-rich DNA. We use the cosmid data to predict that ∼75% of chicken genes are located on microchromosomes.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AJ001643 and AJ001644.]
Understanding users’ switching intentions and switching behavior on social networking sites
Authors: Lin Chun-Nan , Wang Hsiu-Yu 
Published: May 2017

Purpose
The purpose of this paper is to explore the relationship between social networking sites (SNSs) users’ switching intentions and switching behavior. With regard to the former, the authors focus on three factors (perceived value, trust, and perceived risk), and investigate whether and to what extent habit moderates the relationship between SNS-switching intention and actual switching behavior.

Design/methodology/approach
Data collection for this study was carried out using an anonymous survey. The questionnaire was devised based on the literature review. It consisted of a total of 34 items, all of which used the seven-point Likert scale, and was divided into nine sections. Data collection lasted for approximately three months from March to May 2015. Data analysis used SPSS and SmartPLS statistical software packages. First, the descriptive statistics were computed. Next, reliability as a measure of internal consistency was calculated. Then, the relations between all factors were explored.

Findings
Before they switch, users usually evaluate the perceived values and risks of the SNSs they might join, as well as establish the degrees of trust with respect to those networks. Hence, this study is potentially useful to SNS providers planning their business strategies, and/or seeking to optimize their services based on a detailed understanding of the concerns of users and potential users.

Originality/value
This study is of considerable importance to the future development of research on switching intention behavior theory and practice, adding to the body of work on specific frameworks that explain the SNS-switching intention and behavior. The main theoretical implication is that the epistemic value component of the perceived value may not significantly affect switching intentions, at least in the SNS context. In addition, the results regarding the moderating effects of habits are a useful confirmation, in the SNS context, of the findings of a small but important body of prior studies.
Discovery of repost patterns by topic analysis in enterprise social networking
Authors: Luo Jianhong , Pan Xuwei , Zhu Xiyong 
Published: May 2017

Purpose
An increasing number of users are inspired by enterprises to repost social media messages, which greatly contributes to the dissemination of such messages in an online social network. The purpose of this paper is to discover the repost patterns of users regarding enterprise social media messages to help enterprises improve information management abilities for social media.

Design/methodology/approach
This paper proposes a novel method to discover the repost patterns of users in enterprise social networking (ESN) at the macro-level through topic analysis. Speciﬁcally, it proposes the message-diversity metric to measure the latent topic diversity degree of the social media messages. Through this technique, the paper analyzes the message-diversity characteristics of the enterprise social media messages and then explores the repost patterns of users.

Findings
The experimental results show that a high repost rate is more prominent for the messages with diverse latent topics, where message-diversity is as high as 0.5.

Practical implications
The findings have great potential in several management areas, such as employing social media marketing, predicting popular messages, helping enterprises strengthen their online presence, and gathering more potential customers.

Originality/value
This study explores how the repost patterns of users in ESN can be determined through general macro-level behavior of users instead of their micro-level processes. The patterns can also lead to a deeper understanding of which contents can drive people to diffuse information. This study gives an important insight into the information behavior of social media users for enterprise management researchers.
Cultural modernization and work-related values and attitudes
Authors: Yeganeh Hamid 
Published: May 2017

Purpose
The purpose of this study is to rely on the modernization theory to analyze and explain the cross-national differences in work-related values and attitudes (WVA).

Design/methodology/approach
First, the modernization theory and WVA are conceptualized, their relations are discussed and the hypotheses are formulated. Next, the data, measures, variables and empirical tests are presented. Finally, the theoretical and managerial implications are discussed, an integrative model is proposed and avenues for future research are suggested.

Findings
The empirical results confirm the explanatory strength of the modernization theory and provide valuable insights into the patterns of WVA across the world. It is found that the countries involved in the first phase of human development emphasize work centrality, extrinsic aspects of a job and material rewards and are likely to show noticeable discrimination against women and foreign workers. In contrast, post-industrial societies that are involved in the second phase of human development prefer emancipative WVA, such as low work centrality, tolerance of foreign workers, gender equality and hedonism at the workplace.

Research limitations/implications
Despite the remarkable acceptance of the modernization theory, some of Inglehart’s propositions have been subject to criticism. Furthermore, human development, modernization and the subsequent cultural shifts are “path-dependent” as they are affected by the national, religious and civilization heritage of a country.

Practical implications
The findings of this study can help international mangers adopt the appropriate strategies for a wide range of issues, such as staffing, planning, job description and compensation policies.

Originality/value
The modernization theory is a suitable alternative to national cultural dimensions. This approach relies on the premise that socioeconomic development creates consistent patterns of values, beliefs and behaviors that ultimately shape WVA around the globe.
Twin-objective supply chain collaboration to cope with rare but high impact disruptions whilst improving performance
Authors: Zhu Quan , Krikke Harold , Caniëls Marjolein C.J. , Wang Yacan 
Published: May 2017

PurposeRare but high impact (R-HI) disruptions, which are caused by legal changes, socio-technical accidents, or natural disasters, are becoming more frequent and have strong short-term and long-term impacts on performance. Meanwhile, the short-term perspective of managers leads to adoption of mitigation strategies with lower investments and immediate performance improvement. The purpose of this paper is to provide insights on supply chain collaboration (SCC) to establish so-called twin-objective strategy to help both risk mitigation (through moderation effects) and performance improvement (through a direct positive impact). Moreover, power position will be considered as the control variable.Design/methodology/approachA cross-sectional approach was adopted with primary data collected through a survey in China. Data were analyzed using structural equation modeling with partial least squares estimations. A sub-group model analysis was applied to test the effect of the control variable.FindingsThe findings verify that SCC has both a direct positive impact on performance and moderation effects on the relationships between sources of R-HI disruptions and performance. The results of sub-group model analysis illustrate that both powerful and weak focal firms benefit from SCC, but in different ways.Originality/valueThe study shows that the allocation of gains from collaborative advantage should be added to the theory-building of relational view. Meanwhile, the research extends the focal firm’s context to its supply chain’s context so that classic contingency theory can be extended to adequately explain supply chain management phenomena.
An information sharing theory perspective on willingness to share information in supply chains
Authors: Zaheer Nadia , Trkman Peter 
Published: May 2017

PurposeThe quality of information sharing is of the utmost importance for supply chains (SCs). The purpose of this paper is to improve understanding of the human attitude: willingness to share, its antecedents and its role in improving information sharing quality.Design/methodology/approachBased on information sharing theory, a theoretical model and research hypotheses are developed. Data from 387 respondents were collected to test the hypotheses and model fit using structural equation modelling and mediation analysis. The impact of social-psychological factors and information technology (IT) infrastructure capability on willingness to share information and, consequently, its effect on information sharing quality were analysed using IBM SPSS Statistics, PROCESS and AMOS.FindingsThe statistical analysis showed a good model fit. Trust is the most important antecedent for willingness to share, while the impacts of commitment and reciprocity are also significant. Interestingly, power is not a significant antecedent of willingness. Life satisfaction is a significant precursor to willingness to share information, whereas surprisingly overall job satisfaction does not play a significant role.Research limitations/implicationsCross-sectional data were used and the scope was limited to SCs.Practical implicationsManagers should be aware that trust, commitment and reciprocity with their SC partners influence the willingness to share information with varying effects. Access to proper IT capabilities increases willingness as does the life satisfaction. SC individuals who are happy with life are more willing. Interestingly, high power might get the sharer to share information albeit unwillingly.Originality/valueThe model provides a social-psychological understanding of the antecedents of human willingness to share information, which is crucial to sharing quality information. Overall, the social-psychological and IT factors model based on information sharing theory is statistically valid for the SC context.
The influence of supply chain integration on operational performance
Authors: Yuen Kum Fai , Thai Vinh Van 
Published: May 2017

PurposeAn implicit assumption of current supply chain integration (SCI) research is that the results obtained from product supply chains can be directly extrapolated to service supply chains. The purpose of this paper is to question this assumption of equivalence by proposing that the effects of internal integration (II) and external integration (EI) on operational performance (OP) are contingent on whether a firm operates in a product and service supply chain.Design/methodology/approachDrawing on the contingency theory, a model that specifies and contrasts the interrelationships between II, EI, and OP in product and service supply chains was proposed. Subsequently, measures were developed and survey data were collected from 138 product and 174 service companies in Singapore. The data were then analysed using multi-sampling analysis.FindingsThe effects of II and EI on OP varied significantly between product and service supply chains. In addition, the relationship between II and OP was found to be partially mediated by EI in product supply chains whereas a fully mediated relationship was observed in service supply chains.Research limitations/implicationsWithin the context of SCI, different mediation patterns exist in product and service supply chains. The results suggest adopting a contingency rather than a universalistic approach in the management of firms’ internal and external integrative capabilities to maximise OP. Specifically, managers should adjust their II and EI efforts to achieve congruency with the type of supply chain they serve.Originality/valueThis paper tests the assumption of equivalence and extends the current scope of SCI contingency research by cross-examining the effects of II and EI on OP in both product and service supply chains simultaneously.