bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Simulation of Rock‐Avalanche Fragmentation
Authors: Pudasaini Shiva P. , Mergili Martin , Lin Qiwen , Wang Yufeng 
Published: September 2024

AbstractFragmentation is a common phenomenon in complex rock‐avalanches. The fragmentation intensity and process determines exceptional spreading of such mass movements. However, studies focusing on the simulation of fragmentation are still limited and no operational dynamic simulation model of fragmentation has been proposed yet. By enhancing the mechanically controlled landslide deformation model (Pudasaini & Mergili, 2024, https://doi.org/10.1029/2023jf007466), we propose a novel, unified dynamic simulation method for rock‐avalanche fragmentation. The model includes three important aspects: mechanically controlled rock mass deformation, momentum loss while the rock mass fiercely impacts the ground, and the energy transfer during fragmentation resulting in the generation of dispersive lateral pressure. We reveal that the dynamic fragmentation, resulting from the overcoming of the tensile strength by the impact on the ground, leads to enhanced spreading, thinning, run‐out and hypermobility of rock‐avalanches. Thereby, the elastic strain energy release caused by fragmentation becomes an important process. Energy conversion between the front and rear parts caused by the fragmentation results in the enhanced forward movement of the front and hindered motion of the rear of the rock‐avalanche. The new model describes this by amplifying the lateral pressure gradient in the opposite direction: enhanced for the frontal particles and reduced for the rear particles after the fragmentation. The main principle is the switching between the compressional stress and the tensile stress, and therefore from the controlled deformation to substantial spreading of the frontal part in the flow direction while backward stretching of the rear part of the rock mass. Laboratory experiments and field events support our simulation results.
Classifying Plant Communities in the North American Coastal Plain With PRISMA Spaceborne Hyperspectral Imagery and the Spectral Mixture Residual
Authors: Rogers Jennifer A. , Robertson Kevin M. , Hawbaker Todd J. , Sousa Daniel J. 
Published: September 2024

AbstractThe effort to map terrestrial biodiversity, in recent years limited mostly to the use of broadband multispectral remote sensing at decameter scales, can be greatly enhanced by harnessing hyperspectral imagery. Interpretation of hyperspectral imagery may be aided by the Mixture Residual (MR) spectral preprocessing transformation. MR integrates the benefits of spectral mixture analysis with the absorption peak‐enhancing characteristics of continuum removal. MR characterizes each pixel as a linear combination of generic end‐members estimating the spectral continuum, from which the residual of each wavelength is computed and treated as a source of additional information. Using Hyperspectral Precursor of the Application Mission (PRISMA) imagery, we tested the ability of MR‐transformed reflectance as compared to untransformed surface reflectance (SR) to map plant associations and land cover using ground truthing and random forest classifications across four landscapes within the North American Coastal Plain. We used a forward stepwise selection algorithm to choose bands for each classification and subsequently compared these between SR and MR. Our MR classifications distinguished land cover with 5% greater balanced accuracy on average than the SR‐based classifications across all four landscapes. The MR‐based classification that integrated data from all landscapes into a unified model encompassing all 21 land cover types achieved a 76% average balanced accuracy over three iterations. Generally, MR utilized the near‐infrared region to a greater degree than SR while deemphasizing the green peak. Based on our results, MR improves the accuracy of mapping terrestrial biodiversity, likely extending to other current and planned satellite hyperspectral missions.
Varying optimal power for height-standardisation of childhood weight, fat mass and fat-free mass across the obesity epidemic
Authors: Hudda Mohammed T. , Aarestrup Julie , Owen Christopher G. , Baker Jennifer L. , Whincup Peter H. 
Published: September 2024

Abstract
Introduction
Childhood adiposity markers can be standardised for height in the form of indices (marker/heightp) to make meaningful comparisons of adiposity patterns within and between individuals of differing heights. The optimal value of p has been shown to differ by birth year, sex, age, and ethnicity. We investigated whether height powers for childhood weight and fat mass (FM) differed by birth year, sex, or age over the period before and during the child obesity epidemic in Copenhagen.

Setting/methods
Population-based cross-sectional study of 391,801 schoolchildren aged 7 years, 10 years and 13 years, born between 1930 and 1996, from the Copenhagen School Health Records Register. Sex- and age-specific estimates of the height powers for weight and FM were obtained using log–log regression, stratified by a decade of birth.

Results
For weight, amongst children born 1930–39, optimal height powers at 7 years were 2.20 (95% CI: 2.19–2.22) for boys and 2.28 (95% CI: 2.26–2.30) for girls. These increased with birth year to 2.82 (95% CI: 2.76–2.87) and 2.92 (95% CI: 2.87–2.97) for boys and girls born in 1990–96, respectively. For FM, amongst those born 1930–39, powers at 7 years were 2.46 (95% CI: 2.42–2.51) and 2.58 (95% CI: 2.53–2.63) for boys and girls, respectively, and increased with birth year reaching 3.89 (95% CI: 3.75–4.02) and 3.93 (95% CI: 3.80–4.06) for boys and girls born 1990–96, respectively. Powers within birth cohort groups for weight and FM were higher at 10 years than at 7 years, though similar increases across groups were observed at both ages. At 13 years, height powers for weight and FM initially increased with the birth year before declining from the 1970s/80s.

Conclusion
Due to increases in the standard deviation of weight and FM during the obesity epidemic, optimal height powers needed to standardise childhood weight and FM varied by birth year, sex, and age. Adiposity indices using a uniform height power mean different things for different birth cohort groups, sexes, and ages thus should be interpreted with caution. Alternative methods to account for height in epidemiological analyses are needed.
Rewarding properties of L-Dopa in experimental parkinsonism are mediated by sensitized dopamine D1 receptors in the dorsal striatum
Authors: Plewnia Carina , Masini Débora , Fisone Gilberto 
Published: September 2024

Abstract
Treatment of Parkinson’s disease (PD) is based on the use of dopaminergic drugs, such as L-Dopa and dopamine receptor agonists. These substances counteract motor symptoms, but their administration is accompanied by motor and non-motor complications. Among these latter conditions a neurobehavioral disorder similar to drug abuse, known as dopamine dysregulation syndrome (DDS), is attracting increasing interest because of its profound negative impact on the patients’ quality of life. Here we replicate DDS in a PD mouse model based on a bilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. Administration of L-Dopa induced locomotor sensitization and conditioned place preference in 6-OHDA lesion, but not in control mice, indicative of the acquisition of addictive-like properties following nigrostriatal dopamine depletion. These behavioral effects were accompanied by abnormal dopamine D1 receptor (D1R) signaling in the medium spiny neurons of the dorsal striatum, leading to hyperactivation of multiple signaling cascades and increased expression of ΔFosB, a stable transcription factor involved in addictive behavior. Systemic administration of the D1R antagonist, SCH23390, abolished these effects and the development of place preference, thereby counteracting the psychostimulant-like effect of L-Dopa. The rewarding properties of L-Dopa were also prevented by chemogenetic inactivation of D1R-expressing neurons in the dorsal striatum. Our results indicate the association between abnormal D1R-mediated transmission and DDS in PD and identify potential approaches for the treatment of this disorder.
Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery
Authors: Lai Giovanni , Malavolta Marco , Marcozzi Serena , Bigossi Giorgia , Giuliani Maria Elisa , Casoli Tiziana , Balietti Marta 
Published: September 2024

AbstractMajor depressive disorder (MDD) is a severe psychiatric condition that significantly impacts the overall quality of life. Although MDD can occur across all age groups, it is notably prevalent among older individuals, with the aggravating circumstance that the clinical condition is frequently overlooked and undertreated. Furthermore, older adults often encounter resistance to standard treatments, experience adverse events, and face challenges associated with polypharmacy. Given that late-life MDD is associated with heightened rates of disability and mortality, as well as imposing a significant economic and logistical burden on healthcare systems, it becomes imperative to explore novel therapeutic approaches. These could serve as either supplements to standard guidelines or alternatives for non-responsive patients, potentially enhancing the management of geriatric MDD patients. This review aims to delve into the potential of microRNAs targeting Brain-Derived Neurotrophic Factor (BDNF). In MDD, a significant decrease in both central and peripheral BDNF has been well-documented, raising implications for therapy response. Notably, BDNF appears to be a key player in the intricate interplay between microRNA-induced neuroplasticity deficits and neuroinflammation, both processes deeply implicated in the onset and progression of the disease. Special emphasis is placed on delivery methods, with a comprehensive comparison of the strengths and weaknesses of each proposed approach. Our hypothesis proposes that employing multiple microRNAs concurrently, with the ability to directly influence BDNF and activate closely associated pathways, may represent the most promising strategy. Regarding vehicles, although the perfect nanoparticle remains elusive, considering the trade-offs, liposomes emerge as the most suitable option.
Information search under uncertainty across transdiagnostic psychopathology and healthy ageing
Authors: Mohr Greta , Ince Robin A. A. , Benwell Christopher S. Y. 
Published: September 2024

AbstractWhen making decisions in everyday life, we often rely on an internally generated sense of confidence to help us revise and direct future behaviours. For instance, confidence directly informs whether further information should be sought prior to commitment to a final decision. Many studies have shown that aging and both clinical and sub-clinical symptoms of psychopathology are associated with systematic alterations in confidence. However, it remains unknown whether these confidence distortions influence information-seeking behaviour. We investigated this question in a large general population sample (N = 908). Participants completed a battery of psychiatric symptom questionnaires and performed a perceptual decision-making task with confidence ratings in which they were offered the option to seek helpful information (at a cost) before committing to a final decision. Replicating previous findings, an ‘anxious-depression’ (AD) symptom dimension was associated with systematically low confidence, despite no detriment in objective task accuracy. Conversely, a ‘compulsive behaviour and intrusive thoughts’ (CIT) dimension was associated with impaired task accuracy but paradoxical over-confidence. However, neither symptom dimension was significantly associated with an increased or decreased tendency to seek information. Hence, participants scoring highly for AD or CIT did not use the option to information seek any more than average to either increase their confidence (AD) or improve the accuracy of their decisions (CIT). In contrast, older age was associated with impaired accuracy and decreased confidence initially, but increased information seeking behaviour mediated increases in both accuracy and confidence for final decisions. Hence, older adults used the information seeking option to overcome initial deficits in objective performance and to increase their confidence accordingly. The results show an appropriate use of information seeking to overcome perceptual deficits and low confidence in healthy aging which was not present in transdiagnostic psychopathology.
The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma
Authors: Liu Ying-Chieh , Liu So-Yu , Lin Yu-Cheng , Liu Chung-Ji , Chang Kuo-Wei , Lin Shu-Chun 
Published: September 2024

AbstractMetabolic reprogramming sustains malignant head and neck squamous cell carcinoma (HNSCC) to overcome stressful microenvironments, and increased glutamine uptake is a common metabolic hallmark in cancers. Since metabolic reprogramming has been recognized as a new therapeutic target for tumor cells, understanding the regulatory axis of glutamine uptake in HNSCC and its potential downstream effects in its pathogenesis of HNSCC would be incredibly beneficial. Bioinformatic analysis of the Cancer Genome Atlas (TCGA)-HNSCC dataset and RNAseq analysis performed on HNSCC indicated that SLC1A5 was the most dysregulated transporter among the seven homologous glutamate or neutral amino acid transporters in the SLC1A family. To further clarify the role of SLC1A5 in HNSCC, we knocked down SLC1A5 expression. This knockdown decelerated cell growth, induced G0/G1 arrest, diminished tumorigenicity, and increased cleavage caspase3, LC3B, and intracellular Fe2+. Inhibitors against apoptosis, autophagy, or ferroptosis rescued the cell viability repressed by SLC1A5 knockdown. SLC1A5 knockdown also suppressed glutamine uptake, enhanced oxidative stress, and increased sensitivity to cisplatin. CRISPR/dCas9-mediated SLC1A5 induction conferred cisplatin resistance and reduced apoptosis, autophagy, and ferroptosis. Reporter assays and western blot data demonstrated that miR-125b-5p targets and attenuates SLC1A5, while the si-NEAT1 increases miR-125b-5p expression. Analysis of the TCGA-HNSCC databases showed concordant upregulation of NEAT1 and downregulation of miR-125b-5p, along with SLC1A5 upregulation in tumors. Analysis of transcriptomic data revealed that tumors harboring higher SLC1A5 expression had significantly lower immune scores in CD8+, monocytes, and dendritic cells, and higher scores in M0 and M1 macrophages. Disruptions in immune modulation, metabolism, and oxidative stress components were associated with SLC1A5 aberrations in HNSCC. This study concludes that the NEAT1/miR-125b-5p/SLC1A5 cascade modulates diverse activities in oncogenicity, treatment efficacy, and immune cell profiles in head and neck/oral carcinoma.
Costs and cost-effectiveness of the Kerala pilot screening programme for diabetic retinopathy in the public health system
Authors: Wittenberg Raphael , Anderson Robert , Redding Stuart , Gopal Bipin , Sadanandan Rajeev , Sahasranamam Vasudeva Iyer , George Simon , Premnazir Lakshmi , Netuveli Gopalakrishnan , Srinath Jyotsna , Ramakrishnan Radha , Conroy Dolores , Sivaprasad Sobha 
Published: September 2024

Abstract
Background/objectives
The Government of Kerala initiated a pilot screening programme for diabetic retinopathy in 16 Family Health Centres in Thiruvananthapuram district in 2019 in collaboration with the ORNATE India project. The evaluation of this pilot included a study of its costs and cost-effectiveness to inform decisions about extending the programme throughout Kerala.

Subjects/methods
The participants comprise all 5307 people who were screened for diabetic retinopathy under the pilot programme for whom data could be collected.

Results
The costs of the pilot programme are estimated at INR 11.3 million (including INR 1.9 million costs to individuals) and the benefits at 514 QALYs, slightly over one QALY per person treated. The cost per QALY was INR 22,000, which is well below India’s Gross National Income per person.

Conclusions
Kerala’s 2019 pilot screening programme for diabetic retinopathy was highly cost-effective.
Detection and spread of high pathogenicity avian influenza virus H5N1 in the Antarctic Region
Authors: Banyard Ashley C. , Bennison Ashley , Byrne Alexander M. P. , Reid Scott M. , Lynton-Jenkins Joshua G. , Mollett Benjamin , De Silva Dilhani , Peers-Dent Jacob , Finlayson Kim , Hall Rosamund , Blockley Freya , Blyth Marcia , Falchieri Marco , Fowler Zoe , Fitzcharles Elaine M. , Brown Ian H. , James Joe 
Published: September 2024

AbstractUntil recent events, the Antarctic was the only major geographical region in which high pathogenicity avian influenza virus (HPAIV) had never previously been detected. Here we report on the detection of clade 2.3.4.4b H5N1 HPAIV in the Antarctic and sub-Antarctic regions of South Georgia and the Falkland Islands, respectively. We initially detected H5N1 HPAIV in samples collected from brown skuas at Bird Island, South Georgia on 8th October 2023. Since this detection, mortalities were observed in several avian and mammalian species at multiple sites across South Georgia. Subsequent testing confirmed H5N1 HPAIV across several sampling locations in multiple avian species and two seal species. Simultaneously, we also confirmed H5N1 HPAIV in southern fulmar and black-browed albatross in the Falkland Islands. Genetic assessment of the virus indicates spread from South America, likely through movement of migratory birds. Critically, genetic assessment of sequences from mammalian species demonstrates no increased risk to human populations above that observed in other instances of mammalian infections globally. Here we describe the detection, species impact and genetic composition of the virus and propose both introductory routes and potential long-term impact on avian and mammalian species across the Antarctic region. We also speculate on the threat to specific populations following recent reports in the area.
Two KaiABC systems control circadian oscillations in one cyanobacterium
Authors: Köbler Christin , Schmelling Nicolas M. , Wiegard Anika , Pawlowski Alice , Pattanayak Gopal K. , Spät Philipp , Scheurer Nina M. , Sebastian Kim N. , Stirba Florian P. , Berwanger Lutz C. , Kolkhof Petra , Maček Boris , Rust Michael J. , Axmann Ilka M. , Wilde Annegret 
Published: September 2024

AbstractThe circadian clock of cyanobacteria, which predicts daily environmental changes, typically includes a standard oscillator consisting of proteins KaiA, KaiB, and KaiC. However, several cyanobacteria have diverse Kai protein homologs of unclear function. In particular, Synechocystis sp. PCC 6803 harbours, in addition to a canonical kaiABC gene cluster (named kaiAB1C1), two further kaiB and kaiC homologs (kaiB2, kaiB3, kaiC2, kaiC3). Here, we identify a chimeric KaiA homolog, named KaiA3, encoded by a gene located upstream of kaiB3. At the N-terminus, KaiA3 is similar to response-regulator receiver domains, whereas its C-terminal domain resembles that of KaiA. Homology analysis shows that a KaiA3-KaiB3-KaiC3 system exists in several cyanobacteria and other bacteria. Using the Synechocystis sp. PCC 6803 homologs, we observe circadian oscillations in KaiC3 phosphorylation in vitro in the presence of KaiA3 and KaiB3. Mutations of kaiA3 affect KaiC3 phosphorylation, leading to growth defects under both mixotrophic and chemoheterotrophic conditions. KaiC1 and KaiC3 exhibit phase-locked free-running phosphorylation rhythms. Deletion of either system (∆kaiAB1C1 or ∆kaiA3B3C3) alters the period of the cellular backscattering rhythm. Furthermore, both oscillators are required to maintain high-amplitude, self-sustained backscatter oscillations with a period of approximately 24 h, indicating their interconnected nature.
Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome
Authors: Klein Marius , Wild Klemens , Sinning Irmgard 
Published: September 2024

AbstractNascent chains undergo co-translational enzymatic processing as soon as their N-terminus becomes accessible at the ribosomal polypeptide tunnel exit (PTE). In eukaryotes, N-terminal methionine excision (NME) by Methionine Aminopeptidases (MAP1 and MAP2), and N-terminal acetylation (NTA) by N-Acetyl-Transferase A (NatA), is the most common combination of subsequent modifications carried out on the 80S ribosome. How these enzymatic processes are coordinated in the context of a rapidly translating ribosome has remained elusive. Here, we report two cryo-EM structures of multi-enzyme complexes assembled on vacant human 80S ribosomes, indicating two routes for NME-NTA. Both assemblies form on the 80S independent of nascent chain substrates. Irrespective of the route, NatA occupies a non-intrusive ‘distal’ binding site on the ribosome which does not interfere with MAP1 or MAP2 binding nor with most other ribosome-associated factors (RAFs). NatA can partake in a coordinated, dynamic assembly with MAP1 through the hydra-like chaperoning function of the abundant Nascent Polypeptide-Associated Complex (NAC). In contrast to MAP1, MAP2 completely covers the PTE and is thus incompatible with NAC and MAP1 recruitment. Together, our data provide the structural framework for the coordinated orchestration of NME and NTA in protein biogenesis.
Carrier-phonon decoupling in perovskite thermoelectrics via entropy engineering
Authors: Zheng Yunpeng , Zhang Qinghua , Shi Caijuan , Zhou Zhifang , Lu Yang , Han Jian , Chen Hetian , Ma Yunpeng , Zhang Yujun , Lin Changpeng , Xu Wei , Ma Weigang , Li Qian , Yang Yueyang , Wei Bin , Yang Bingbing , Zou Mingchu , Zhang Wenyu , Liu Chang , Dou Lvye , Yang Dongliang , Lan Jin-Le , Yi Di , Zhang Xing , Gu Lin , Nan Ce-Wen , Lin Yuan-Hua 
Published: September 2024

AbstractThermoelectrics converting heat and electricity directly attract broad attentions. To enhance the thermoelectric figure of merit, zT, one of the key points is to decouple the carrier-phonon transport. Here, we propose an entropy engineering strategy to realize the carrier-phonon decoupling in the typical SrTiO3-based perovskite thermoelectrics. By high-entropy design, the lattice thermal conductivity could be reduced nearly to the amorphous limit, 1.25 W m−1 K−1. Simultaneously, entropy engineering can tune the Ti displacement, improving the weighted mobility to 65 cm2 V−1 s−1. Such carrier-phonon decoupling behaviors enable the greatly enhanced μW/κL of ~5.2 × 103 cm3 K J−1 V−1. The measured maximum zT of 0.24 at 488 K and the estimated zT of ~0.8 at 1173 K in (Sr0.2Ba0.2Ca0.2Pb0.2La0.2)TiO3 film are among the best of n-type thermoelectric oxides. These results reveal that the entropy engineering may be a promising strategy to decouple the carrier-phonon transport and achieve higher zT in thermoelectrics.