bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembrolizumab in Patients With Extensive-Stage Small-Cell Lung Cancer: Results From the Phase Ib KEYNOTE-028 Study
Authors: Ott Patrick A. , Elez Elena , Hiret Sandrine , Kim Dong-Wan , Morosky Anne , Saraf Sanatan , Piperdi Bilal , Mehnert Janice M. 
Published: August 2017

Purpose The safety and efficacy of pembrolizumab, a humanized monoclonal antibody against programmed death 1 (PD-1), were assessed in patients with programmed death ligand 1 (PD-L1)–expressing extensive-stage small-cell lung cancer (SCLC) in the multicohort, phase Ib open-label KEYNOTE-028 study ( ClinicalTrials.gov identifier: NCT02054806). Methods Patients with SCLC received pembrolizumab 10 mg/kg every 2 weeks for 24 months or until disease progression or intolerable toxicity occurred. PD-L1 expression was assessed by immunohistochemistry. PD-L1–positive patients had membranous PD-L1 expression in ≥ 1% of tumor and associated inflammatory cells or positive staining in stroma. Response was assessed by investigator per Response Evaluation Criteria in Solid Tumors version 1.1 every 8 weeks for the first 6 months and every 12 weeks thereafter. Adverse events (AEs) were reported per the National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0. Primary end points were safety, tolerability, and objective response rate (ORR). Secondary end points included progression-free survival, overall survival, and duration of response. Results Twenty-four patients with PD-L1–expressing SCLC were enrolled and received at least one pembrolizumab dose. At the data cutoff date (June 20, 2016), the median follow-up duration was 9.8 months (range, 0.5 to 24 months). All 24 patients experienced AEs; the most common were asthenia (n = 7), fatigue (n = 7), and cough (n = 6). Two patients experienced grade 3 to 5 treatment-related AEs: one patient had elevated bilirubin, and one patient had asthenia, grade 5 colitis, and intestinal ischemia. One patient had a complete response, and seven patients had partial responses, resulting in an ORR of 33% (95% CI, 16% to 55%). Conclusion The safety of pembrolizumab was consistent with the known safety profile in other tumor types. Pembrolizumab demonstrated promising antitumor activity in patients with pretreated, PD-L1–expressing SCLC.
Effect and Efficiency of an Embedded Palliative Care Nurse Practitioner in an Oncology Clinic
Authors: Walling Anne M. , D’Ambruoso Sarah F. , Malin Jennifer L. , Hurvitz Sara , Zisser Ann , Coscarelli Anne , Clarke Robin , Hackbarth Andrew , Pietras Christopher , Watts Frances , Ferrell Bruce , Skootsky Samuel , Wenger Neil S. 
Published: August 2017

Purpose: To test a simultaneous care model for palliative care for patients with advanced cancer by embedding a palliative care nurse practitioner (NP) in an oncology clinic. Methods: We evaluated the effect of the intervention in two oncologists’ clinics beginning March 2014 by using implementation strategies, including use of a structured referral mechanism, routine symptom screening, integration of a psychology-based cancer supportive care center, implementation team meetings, team training, and a metrics dashboard for continuous quality improvement. After 1 year of implementation, we evaluated key process and outcome measures for supportive oncology and efficiency of the model by documenting tasks completed by the NP during a subset of patient visits and time-motion studies. Results: Of approximately 10,000 patients with active cancer treated in the health system, 2,829 patients had advanced cancer and were treated by 42 oncologists. Documentation of advance care planning increased for patients of the two intervention oncologists compared with patients of the other oncologists. Hospice referral before death was not different at baseline, but was significantly higher for patients of intervention oncologists compared with patients of control oncologists (53% v 23%; P = .02) over the intervention period. Efficiency evaluation revealed that approximately half the time spent by the embedded NP potentially could have been completed by other staff (eg, a nurse, a social worker, or administrative staff). Conclusion: An embedded palliative care NP model using scalable implementation strategies can improve advance care planning and hospice use among patients with advanced cancer.
Participant Attitudes Toward an Intensive Trial of Multiple Biopsies, Multidimensional Molecular Analysis, and Reporting of Results in Metastatic Triple-Negative Breast Cancer
Authors: Kuderer Nicole M. , Burton Kimberly A. , Blau Sibel , Senecal Francis , Gadi Vijayakrishna K. , Parker Stephanie , Mahen Elisabeth , Veenstra David , Carlson Josh J. , Lyman Gary H. , Blau C. Anthony 
Published: August 2017

Purpose Multidimensional molecular analysis of tumor tissue intensively over space and time can provide insight into how cancers evolve and escape treatment. Attitudes of participants in such trials have not been assessed. We explored patient views regarding an intensive study incorporating multiple biopsies, multidimensional molecular testing, and drug response predictions that are reported to the oncologist and patient. Patients and Methods A structured, self-administered survey was conducted among the first 15 patients enrolled in ITOMIC-001 (Intensive Trial of Omics in Cancer). Patients with metastatic triple-negative breast cancer were accrued at two sites in Washington state. Surveys containing 17 items were administered at enrollment and after the return of results. Surveys explored perceptions regarding risks, personal benefits, benefits to others, uncertainties associated with interpreting complex molecular results, concerns regarding multiple biopsies, and potential loss of confidentiality. At follow-up, three additional unique items explored patient coping. Results All participants expressed a strong desire for their experiences to benefit others, and all perceived a higher likelihood of deriving benefit than described during detailed consent discussions. Loss of confidentiality ranked lowest among patient concerns. Despite acknowledging uncertainties and risks inherent in complex molecular testing for clinical reporting, participants wanted access to findings in evaluating treatment choices, even if the best available evidence was weak. Follow-up surveys demonstrated relatively little change in attitudes, although concern about study biopsies generally declined. Study participation helped several patients cope better with their disease. Conclusion In advanced breast cancer, these findings demonstrate the feasibility of engaging motivated patients in trials that navigate the uncertainties associated with intensive spatial and longitudinal multidimensional molecular testing for the purpose of advancing precision medicine.
The Skyscraper’s Unseeing Eyes: Louis Sullivan, Nella Larsen, and Racial Formalism
Authors: Shon Sue 
Published: August 2017

Abstract
Since its inception, the skyscraper has served as an icon of American innovation, modernity, and freedom. Upholding this image has erased the racial thinking and racist practices foundational to this born-and-bred American architectural form. This essay restores the import of race to the skyscraper by reading formalist theories by the father of modern architecture, Louis Sullivan, alongside a work of African American modernist fiction, Nella Larsen’s Passing (1929). Reading Sullivan alongside Larsen explains how skyscrapers and blackness together have defined what gets seen as modern. The unexpected pairing reveals the visual racial logics built into skyscraper aesthetics and adds an architectural thread to the well-established scholarship on Larsen’s novel.
The Gothic Origins of Global Health
Authors: Altschuler Sari 
Published: August 2017

AbstractGlobal health traces its origins back to a single moment in 1854 when John Snow eradicated cholera with a map. It is a nice story, but it’s a myth, a fantasy of empiricism. The modern global health approach did begin with the nineteenth-century, worldwide cholera pandemics, but cartography was not the principal form associated with this paradigm; it was the gothic. Turning back to the mid-nineteenth-century pandemics, this essay explores the contours of an emergent global health approach on both sides of the Atlantic. It demonstrates why the gothic was the form through which this approach was narrated, how the form worked, and the effects of the genre on popular and medical knowledge. Contemporary global health has been reorganized around scientific empiricism, but elements of its gothic history remain. I conclude by suggesting the value of recuperating these gothic origins for global health today.
Homing pigeons (Columba livia) modulate wingbeat characteristics as a function of route familiarity
Authors: Taylor Lucy A. , Portugal Steven J. , Biro Dora 
Published: August 2017

ABSTRACT
Mechanisms of avian navigation have received considerable attention, but whether different navigational strategies are accompanied by different flight characteristics is unknown. Managing energy expenditure is critical for survival; therefore, understanding how flight characteristics, and hence energy allocation, potentially change with birds' familiarity with a navigational task could provide key insights into the costs of orientation. We addressed this question by examining changes in the wingbeat characteristics and airspeed of homing pigeons (Columba livia) as they learned a homing task. Twenty-one pigeons were released 20 times individually either 3.85 or 7.06 km from home. Birds were equipped with 5 Hz GPS trackers and 200 Hz tri-axial accelerometers. We found that, as the birds' route efficiency increased during the first six releases, their median peak-to-peak dorsal body (DB) acceleration and median DB amplitude also increased. This, in turn, led to higher airspeeds, suggesting that birds fly slower when traversing unfamiliar terrain. By contrast, after route efficiency stabilised, birds exhibited increasing wingbeat frequencies, which did not result in further increases in speed. Overall, higher wind support was also associated with lower wingbeat frequencies and increased DB amplitude. Our study suggests that the cost of early flights from an unfamiliar location may be higher than subsequent flights because of both inefficient routes (increased distance) and lower airspeeds (increased time). Furthermore, the results indicate, for the first time, that birds modulate their wingbeat characteristics as a function of navigational knowledge, and suggest that flight characteristics may be used as ‘signatures’ of birds' route familiarity.
Effects of a social cue on reproductive development and pre-alternate molt in seasonally breeding migrant and resident female songbirds (Zonotrichia leucophrys)
Authors: Chmura Helen E. , Meddle Simone L. , Wingfield John C. , Hahn Thomas P. 
Published: August 2017

ABSTRACTTo time reproduction optimally, birds have evolved diverse mechanisms by which they respond to environmental changes that help them anticipate and prepare for the breeding season. While residents initiate reproductive preparation and breed in the same geographic location, migrant birds simultaneously prepare for breeding and migration far from their breeding grounds. As a result, it is hypothesized that migrant and resident birds use environmental cues differently to prepare to breed and that there is adaptive specialization in mechanisms regulating reproductive preparation. Specifically, residents are expected to rely more on non-photic cues (e.g. food, temperature, social cues) than migrants. We tested this general prediction using a social cue manipulation. First, we compared the effects of subspecies-appropriate recorded male song on reproductive development in migrants and residents on a naturally increasing photoperiod. Second, we tested the sensitivity of migrant-specific life history events (fattening and pre-alternate molt) to song treatment. After 82 days, residents had higher luteinizing hormone and greater ovarian development than migrants, but song treatment had no effect on these metrics in either subspecies. Song advanced pre-alternate molt but had no effect on fattening in migrants. While our study does not support specialization in social cue use in migrants and residents, it is consistent with findings in the literature of specialization in photoperiodic response. It also demonstrates for the first time that social cues can influence molt in a migrant species. Additional findings from a pilot study looking at responses to a live male suggest it is important to test other kinds of social cues.
Professional medical writing support and the reporting quality of randomized controlled trial abstracts among high-impact general medical journals
Authors: Mills Ira , Sheard Catherine , Hays Meredith , Douglas Kevin , Winchester Christopher C. , Gattrell William T. 
Published: August 2017

Background: In articles reporting randomized controlled trials, professional medical writing support is associated with increased adherence to Consolidated Standards of Reporting Trials (CONSORT). We set out to determine whether professional medical writing support was also associated with improved adherence to CONSORT for Abstracts.Methods: Using data from a previously published cross-sectional study of 463 articles reporting randomized controlled trials published between 2011 and 2014 in five top medical journals, we determined the association between professional medical writing support and CONSORT for Abstracts items using a Wilcoxon rank-sum test.Results: The mean proportion of adherence to CONSORT for Abstracts items reported was similar with and without professional medical writing support (64.3% vs 66.5%, respectively; p=0.30). Professional medical writing support was associated with lower adherence to reporting study setting (relative risk [RR]; 0.40; 95% confidence interval [CI], 0.23–0.70), and higher adherence to disclosing harms/side effects (RR 2.04; 95% CI, 1.37–3.03) and funding source (RR 1.75; 95% CI, 1.18–2.60).Conclusions: Although professional medical writing support was not associated with increased overall adherence to CONSORT for Abstracts, important aspects were improved with professional medical writing support, including reporting of adverse events and funding source. This study identifies areas to consider for improvement.
Residual Inflation Risk
Authors: Illeditsch Philipp Karl 
Published: August 2017

I decompose inflation risk into (i) a component that is correlated with factors that determine investors’ preferences and investment opportunities and real returns on real assets with risky cash flows (stocks, corporate bonds, real estate, commodities, etc.), and (ii) a residual inflation risk component. In equilibrium, only the first component earns a risk premium. Therefore, investors should avoid exposure to the residual component. All nominal bonds, including money-market accounts, have constant nominal cash flows, and thus their real returns are equally exposed to residual inflation risk. In contrast, inflation-protected bonds provide a means to avoid cash flow and residual inflation risk. Hence, every investor should put 100% of her wealth in real assets (inflation-protected bonds, stocks, corporate bonds, real estate, commodities, etc.) and finance every long/short position in nominal bonds with an equal amount of other nominal bonds or by borrowing/lending cash; that is, investors should hold a zero-investment portfolio of nominal bonds and cash. This paper was accepted by Neng Wang, finance.
High-Resolution, Accurate-Mass (HRAM) Mass Spectrometry Urine Steroid Profiling in the Diagnosis of Adrenal Disorders
Authors: Hines Jolaine M , Bancos Irina , Bancos Cristian , Singh Raman D , Avula Aditya V , Young William F , Grebe Stefan K , Singh Ravinder J 
Published: August 2017

Abstract

BACKGROUND
Steroid profiling is a promising diagnostic tool with adrenal tumors, Cushing syndrome (CS), and disorders of steroidogenesis. Our objective was to develop a multiple-steroid assay using liquid-chromatography, high-resolution, accurate-mass mass spectrometry (HRAM LC-MS) and to validate the assay in patients with various adrenal disorders.

METHODS
We collected 24-h urine samples from 114 controls and 71 patients with adrenal diseases. An HRAM LC-MS method was validated for quantitative analysis of 26 steroid metabolites in hydrolyzed urine samples. Differences in steroid excretion between patients were analyzed based on Z-score deviation from control reference intervals.

RESULTS
Limits of quantification were 20 ng/mL. Dilution linearity ranged from 80% to 120% with means of 93% to 110% for all but 2 analytes. Intraassay and interassay imprecision ranged from 3% to 18% for all but 1 analyte. Control women had lower excretion of androgen and glucocorticoid precursors/metabolites than men (P &lt; 0.001), but no difference in mineralocorticoids was seen (P = 0.06). Androgens decreased with age in both sexes (P &lt; 0.001). Compared with patients with adrenocortical adenoma (ACA), patients with adrenocortical carcinoma (ACC) had 11 steroids with increased Z scores, especially tetrahydro-11-deoxycortisol (14 vs 0.5, P &lt; 0.001), pregnanetriol (7.5 vs −0.4, P = 0.001), and 5-pregnenetriol (5.4 vs −0.4, P = 0.01). Steroid profiling also demonstrated metabolite abnormalities consistent with enzymatic defects in congenital adrenal hyperplasia and differences in pituitary vs adrenal CS.

CONCLUSIONS
Our HRAM LC-MS assay successfully quantifies 26 steroids in urine. The statistically significant differences in steroid production of ACC vs ACA, adrenal vs pituitary CS, and in congenital adrenal hyperplasia should allow for improved diagnosis of patients with these diseases.
Children’s Hospitals’ Solutions for Patient Safety Collaborative Impact on Hospital-Acquired Harm
Authors: Lyren Anne , Brilli Richard J. , Zieker Karen , Marino Miguel , Muething Stephen , Sharek Paul J. 
Published: August 2017

OBJECTIVES:
To determine if an improvement collaborative of 33 children’s hospitals focused on reliable best practice implementation and culture of safety improvements can reduce hospital-acquired conditions (HACs) and serious safety events (SSEs).

METHODS:
A 3-year prospective cohort study design with a 12-month historical control population was completed by the Children’s Hospitals’ Solutions for Patient Safety collaborative. Identification and dissemination of best practices related to 9 HACs and SSE reduction focused on key process and culture of safety improvements. Individual hospital improvement teams leveraged the resources of a large, structured children’s hospital collaborative using electronic, virtual, and in-person interactions.

RESULTS:
Thirty-three children’s hospitals from across the United States volunteered to be part of the Children’s Hospitals’ Solutions for Patient Safety collaborative. Thirty-two met all the data submission eligibility requirements for the HAC improvement objective of this study, and 21 participated in the high-reliability culture work aimed at reducing SSEs. Significant harm reduction occurred in 8 of 9 common HACs (range 9%–71%; P &lt; .005 for all). The mean monthly SSE rate decreased 32% (from 0.77 to 0.52; P &lt; .001). The 12-month rolling average SSE rate decreased 50% (from 0.82 to 0.41; P &lt; .001).

CONCLUSIONS:
Participation in a structured collaborative dedicated to implementing HAC-related best-practice prevention bundles and culture of safety interventions designed to increase the use of high-reliability organization practices resulted in significant HAC and SSE reductions. Structured collaboration and rapid sharing of evidence-based practices and tools are effective approaches to decreasing hospital-acquired harm.
Status of neonatal death in sick newborn care unit of a tertiary care hospital
Authors: Mishra Ashish Kumar , Panda Sadhu Charan 
Published: August 2017

Background: In view of clusters of death in Sick New Born Care Units of tertiary care hospitals in recent past and few studies done so far in this field necessitates a research. The aim of the present study was to assess the factors associated with neonatal mortality and the infrastructure of the SNCU.Methods: All sick neonates admitted in the SNCU during June and July 2017 were followed up till they were discharged or declared dead. Data were collected by facility observation, interview of parents/attendants and from patient case sheet with a predesigned a pretested questionnaire and were analyzed applying appropriate statistical methods.Results: Prevalence neonatal death was 12 per cent among 250 sick neonates studied. Majority of neonatal deaths occurred among mothers having lower SE Status 25 (27.4), antenatal visits less than 4 times (22, 22%), undernourished neonates (24, 37.5%) all of which were significant. Majority of morbidity were of Prematurity, (110, 44%) followed by Birth Asphyxia (96, 38.4%) and Infections (35.2%) and leading cause of death was infection. There was a deficit of resources from 25% to 75% and no monitoring and supervision were done till date.Conclusions: Health care delivery system at block level and below needs to be strengthened in terms of antenatal visits, improvement of nutritional status of mother. The resource constraint of SNCU at tertiary care hospital and surveillance and monitoring mechanism requires prompt action to make SNCU more effective.
Safety and Efficacy of Rotigotine for Treating Parkinson’s Disease: A Meta-Analysis of Randomised Controlled Trials
Authors: Chen Fei , Jin Lingjing , Nie Zhiyu 
Published: August 2017

We aimed to comprehensively analyse the safety and efficiency of rotigotine for treating Parkinson’s disease (PD). We conducted systematic literature searches of Cochrane library, PubMed and Embase databases up to April 2016, with ‘Rotigotine’, ‘Parkinson Disease ’ and ‘Parkinson’s disease’ as key searching terms. Outcomes, including Unified Parkinson’s Disease Rating Scale (UPDRS) Part III and Part II scores, ‘off’ time, adverse events (AEs), serious AEs and discontinuation because of AEs, were compared between rotigotine and placebo groups under a fixed or random effect model. For dichotomous and continuous data, risk ratio (RR) and weighted mean difference with their corresponding 95% confidence intervals (95% CIs) were taken as the effect sizes to calculate merged results. Twelve eligible studies were included. For patients with early or advanced PD, rotigotine could significantly improve UPDRS Part III and Part II scores (p < 0.001) and it had significantly higher incidence of AEs than the placebo (p < 0.001). Regarding discontinuation because of AEs, rotigotine showed a significant advantage over placebo in patients with early PD, whereas the overall result demonstrated no statistically significant difference between the groups. Rotigotine can improve daily living and motor ability of patients with PD, although it has higher incidence of AEs. Rotigotine might be more appropriate for patients with advanced PD than for those with early PD. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.