bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of breast MRI in high‐risk patients with newly diagnosed breast cancer to exclude invasive disease in the contralateral prophylactic mastectomy: Is there a role to choose wisely patients for sentinel node biopsy?
Authors: Freitas Vivianne , Crystal Pavel , Kulkarni Supriya R. , Ghai Sandeep , Bukhanov Karina , Escallon Jaime , Scaranelo Anabel M. 
Published: March 2016

AbstractThe aim of this study was to evaluate the presence of clinically and mammographically occult disease using breast MRI in a cohort of cancer patients undergoing contralateral prophylactic mastectomy (CPM) and the utmost indication of axillary assessment (sentinel node biopsy (SLNB)) for this side. A retrospective review of patients with unilateral invasive breast cancer or ductal carcinoma in situ (DCIS) from institutional MRI registry data (2004–2010) was conducted. Characteristics of patients undergoing CPM with breast MRI obtained less than 6 month before surgery were evaluated. A total of 2322 consecutive patients diagnosed with DCIS or stage I to III infiltrating breast cancer underwent preoperative breast MRI. Of these, 1376 patients (59.2%) had contralateral clinical breast exam and mammography without abnormalities; and 116 patients (4.9%) underwent CPM (28 excluded patients had breast MRI more than 6 months before CPM). The mean age of the 88 patients was 49 years (range 28–76 years). Two (2.3%) DCIS identified on surgical pathology specimen were not depicted by MRI and the 5 mm T1N0 invasive cancer (1.1%) was identified on MRI. Preoperative MRI showed 95% accuracy to demonstrate absence of occult disease with negative predicted value (NPV) of 98% (95% CI: 91.64–99.64%). Occult disease was present in 3.4% of CPM. MRI accurately identified the case of invasive cancer in this cohort. The high negative predictive value suggests that MRI can be used to select patients without consideration of SLNB for the contralateral side.
Multiplex determination of serological signatures in the sera of colorectal cancer patients using hydrogel biochips
Authors: Butvilovskaya Veronika I. , Popletaeva Sofya B. , Chechetkin Vladimir R. , Zubtsova Zhanna I. , Tsybulskaya Marya V. , Samokhina Larisa O. , Vinnitskii Leonid I. , Ragimov Aligeydar A. , Pozharitskaya Elena I. , Grigor´eva Galina A. , Meshalkina Natalya Y. , Golysheva Svetlana V. , Shilova Nadezhda V. , Bovin Nicolai V. , Zasedatelev Aleksander S. , Rubina Alla Y. 
Published: March 2016

AbstractColorectal cancer (CRC) is the third most common malignancy in industrialized countries. Despite the advances in diagnostics and development of new drugs, the 5‐year survival remains only 60–65%. Our approach to early diagnostics of CRC is based on the determination of serological signatures with an array of hemispherical hydrogel cells containing immobilized proteins and oligosaccharides (glycochip). The compounds immobilized on the glycochip include tumor‐associated glycans (SiaTn, Tn, TF, LeC, LeY, SiaLeA, and Manβ1‐4GlcNAcβ) and antibodies against human immunoglobulins IgG, IgA, and IgM. The glycochip detects antibodies against tumor‐associated glycans in patients’ sera. The simultaneous measurement of the levels of immunoglobulins enhances the diagnostic impact of the signatures. In this work, we found previously unreported increase in antibodies against oligosaccharide Manβ1‐4GlcNAcβ in patients with CRC. In parallel with these experiments, we determined the levels of oncomarkers carcinoembryonic antigen (CEA), cancer antigen (CA) 19–9, CA 125, CA 15–3, human chorionic gonadotropin (HCG), and alpha‐fetoprotein (AFP) using another gel‐based biochip with immobilized antibodies (oncochip) developed earlier in our laboratory. In total, 69 samples from healthy donors, 33 from patients with colorectal carcinoma, and 27 from patients with inflammatory bowel diseases were studied. The use of combined signatures of antiglycan antibodies and oncomarkers provides much better predictive value than the conventional measurement of oncomarkers CEA and CA 19–9. Positive predictive value of CRC diagnoses using together glycochip and oncochip reached 95% with the sensitivity and specificity 88% and 98%, respectively. Thus, the combination of antibody profiling with detection of conventional oncomarkers proved to be a promising tool in diagnostics of CRC.
Dynamic changes of driver genes’ mutations across clinical stages in nine cancer types
Authors: Li Xia 
Published: March 2016

AbstractThe driver genes play critical roles for tumorigenesis, and the number of identified driver genes reached plateau. But how they act during different cancer development stages is lack of knowledge. We investigated 138 driver genes’ mutation changes across clinical stages using 3,477 cases in nine cancer types from the Cancer Genome Atlas (TCGA) and constructed their temporal order relationships. We also examined the codon changes for the widely mutated TP53 and PIK3CA in tumor stages. Combinations of one to three driver genes specifically dominated in each cancer. Across the clinical stages, we categorized three patterns for the behaviors of driver genes’ mutation changes in the nine cancer types: recurrently mutated in all the stages and triggering other mutations; certain mutations lost meanwhile other mutations emerged; mutations dominated across entire stages, while other mutations gradually appeared or disappeared. We observed different codon changes dominated in different stages and revealed mutations recurrently occurring on the hotspot regions of the coding sequence may be the core factor for driver genes’ tumorigenesis. Our results highlighted the dynamic changes of oncogenesis roles in different clinical stages and suggested different diagnostic decision making according to the clinical stages of patients.
Monitoring Conformational Changes in the Receptor Tyrosine Kinase EGFR
Authors: Becker Christian , Öcal Sinan , Nguyen Hoang D. , Phan Trang , Keul Marina , Simard Jeffrey R. , Rauh Daniel 
Published: March 2016

AbstractThe receptor tyrosine kinase EGFR is regulated by complex conformational changes, and this conformational control is disturbed in certain types of cancer. Many ligands are known to bind EGFR in its active conformation, thereby preventing ATP from binding. Only a few ligands are known to stabilize EGFR in its inactive conformation, thus providing novel strategies for perturbing EGFR activity. We report a direct binding assay that enables the identification of novel ligands that bind to and stabilize the inactive conformation of EGFR.
Tube formation in the first trimester placental trophoblast cells: Differential effects of angiogenic growth factors and fatty acids
Authors: Pandya Abhilash D. , Das Mrinal K. , Sarkar Arnab , Vilasagaram Srinivas , Basak Sanjay , Duttaroy Asim K. 
Published: March 2016

AbstractThe study aims to investigate whether cytosolic fatty acid‐binding protein‐4 (FABP4) is involved in angiogenic growth factors‐ and fatty acid‐induced tube formation in first trimester placental trophoblast cells, HTR8/SVneo. We determined the tube formation both at basal as well as stimulated levels in the absence and presence of inhibitors of FABP4 and VEGF signaling pathways. Basal level of tube formation was maximally reduced in the presence of 50 µM of FABP4 inhibitor compared with those by VEGF signaling pathway inhibitors (rapamycin, L‐NAME, and p38 MAP kinase inhibitor). Whereas docosahexaenoic acid, 22:6n‐3 (DHA)‐, and VEGF‐induced tube formation was maximally inhibited by p38 MAP kinase inhibitor (63.7 and 34.5%, respectively), however, leptin‐induced tube formation was inhibited maximally by FABP4 inhibitor (50.7%). ANGPTL4 and oleic acid (OA)‐induced tube formation was not blocked by any of these inhibitors. The FABP4 inhibitor inhibited cell growth stimulated by DHA, leptin, VEGF, and OA (P < 0.05) but was not affected by ANGPTL4. VEGF, leptin, and OA also increased FABP4 protein level in these cells, though the uptake of fatty acids by these cells was not affected by the presence of FABP4 inhibitor. Our data demonstrate that FABP4 may be involved in part in the basal level, and stimulated tube formation by VEGF, DHA, and leptin, whereas it has little or no effect in ANGPTL4‐ and OA‐induced tube formation in these cells. Thus, FABP4 may play a differential role in fatty acids and angiogenic growth factors‐mediated tube formation in the first trimester trophoblast cells in vitro.
Asymmetric dimethylarginine (ADMA) treatment induces apoptosis in cultured rat mesangial cells via endoplasmic reticulum stress activation
Authors: Park Min‐Jung , Oh Ki‐Seok , Nho Jong‐Hyun , Kim Gye‐Yeop , Kim Dong‐Il 
Published: March 2016

AbstractAsymmetric dimethylarginine (ADMA), a high risk factor for endothelial dysfunction and cardiovascular disease (CVD), has been reported to promote cellular dysfunction via endoplasmic reticulum (ER) stress activation in various cells. Additionally, increased serum ADMA levels have been observed in incipient kidney diseases. Previously, we reported that activated ER stress is associated with mesangial cell apoptosis, observed mainly in overt nephropathy or chronic kidney disease (CKD). However, the effect of ADMA on mesangial cell apoptosis is unknown. Thus, we investigated the effects of ADMA on mesangial cell apoptosis and ER stress signaling. ADMA treatment increased caspase‐3 activity and activated three branches of ER stress signaling (PERK, IRE1, and ATF6) that induce mesangial cell apoptosis. Pharmacological inhibitors of ER stress (inhibitors of PERK, IRE1, and S1P) attenuated ADMA‐induced cleavage of caspase‐3 and induced a decrease in the mitochondrial membrane potential. Furthermore, these inhibitors diminished the number of apoptotic cells induced by ADMA treatment. Taken together, our results indicated that ADMA treatment induces mesangial cell apoptosis via ER stress signaling. These results suggest that ADMA‐induced mesangial cell apoptosis could contribute to the progression of overt nephropathy and CKD.
Severe cerebral involvement due to idiopathic systemic capillary leak syndrome
Authors: Günes Ali Riza , Berlit Peter , Weber Ralph 
Published: March 2016

Key Clinical MessageThe idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder, characterized by recurrent attacks of hypotension, hypoalbuminemia, and hemoconcentration, which is often misdiagnosed due to overlapping features with other diseases. Even though cerebral involvement is uncommon, a broad awareness is crucial, because of its life‐threatening character.
Ionic and Electronic Transport in Alluaudite Na2+2xFe2−x(SO4)3
Authors: Lu Jiechen , Yamada Atsuo 
Published: March 2016

AbstractAlluaudite‐type Na2+2xFe2−x(SO4)3 has recently been discovered as a 3.8 V (highest ever Fe3+/Fe2+ redox potential) cathode material for sodium‐ion batteries. Contrary to the sluggish kinetics caused by the large Na+ radius in most cathode materials for sodium‐ion batteries, this alluaudite‐type compound shows superior high‐rate capability during electrochemical cycling. Here, to explore the underlying factors for the fast kinetics, we experimentally investigate the inherent ionic and electronic transport of this alluaudite phase by using impedance spectroscopy and potentiostatic polarization. Compared with the commercial cathode material, LiFePO4, we demonstrate four and two orders of magnitude higher intrinsic ionic and electronic conductivity, respectively, which underpin its superior high‐rate capability in terms of electrode performance.
Heteroatom Effects on the Optical and Electrochemical Properties of Ag25(SR)18 and Its Dopants
Authors: Kang Xi , Chen Shuang , Jin Shan , Song Yongbo , Xu Yajie , Yu Haizhu , Sheng Hongting , Zhu Manzhou 
Published: March 2016

AbstractThe structure–property correlations of silver nanoclusters (NCs) have rarely been studied, owing to the lack of appropriate materials and the instability of silver NCs. Herein, we show that substituting the central atom of the Ag25(SR)18 NC with another metal atom (i.e. Pd, Pt, or Au) can influence the optical and electrochemical properties. The significant blueshift in optical absorption spectra (compared to Ag25) illustrates the unique electronic perturbation caused by the incorporated heteroatom. In addition, voltammetric measurements were performed to explore the electrochemical properties of Ag NCs for the first time. The O2−O1 potential spacings for different NCs follow the sequence of Pd1Ag24< Ag25< Pt1Ag24< Au1Ag24, and this sequence explains the instability of Ag25 compared to Au1Ag24. Meanwhile, the HOMO–LUMO gaps calculated from differential pulse voltammetry measurements are consistent with those derived from the optical absorption spectra. This study provides further understanding of the structure–property correlations of Ag NCs.
ChemInform Abstract: A SECOND ORDER PERTUBATION THEORY FOR SYSTEMS WITH ′SOFT′ INTERMOLECULAR REPULSIONS
Authors: BOUBLIK T. 
Published: March 2016

AbstractEin einfacher Störungsausdruck 2. Ordnung für Systeme wird vorgeschlagen, die aus einfachen Kugelmolekülen mit einem Paarwechselwirkungspotential bestehen, das einen Term weicher Abstoßung enthält.
ChemInform Abstract: EFFECT OF HALOGENIDE IONS AND MONOVALENT CATIONS ON THE FORMATION OF A MULTILAYER OXIDE ON A PLATINUM ELECTRODE
Authors: SPALEK O. , BALEJ J. 
Published: March 2016

AbstractDer Einfluß einwertiger Kationen und Anionen auf die Bildungsgeschwindigkeit von Oberflächenoxiden auf Pt in In H2SO4 bei Potentialen von 2,0‐2,8 V (gegen eine H2‐Elektrode) wird untersucht.
ChemInform Abstract: IONEN‐ UND ISOTOPENAUSTAUSCH AN K2SIF6‐NIEDERSCHLAEGEN
Authors: WINZER ACHIM , GEYER RUDOLF , SYRING WOLFGANG 
Published: March 2016

AbstractK2SiF6‐Niederschläge wurden aus ZnSiF6‐Lösung mit KNO3 in wäßrigem Methanol erhalten.
ChemInform Abstract: EINFLUSS DER WERTIGKEIT UND DES IONENRADIUS VON ZUSAETZEN AUF DIE STRUKTUR UND DIE DEHYDRIERUNGSAKTIVITAET DES SYSTEMS AL2O3‐CR2O3 (MIT 7,5 MOL‐PROZENTIGEM CR2O3) 2. MITT. NATUR DER BEI DER DEHYDRIERUNG AKTIVEN PLAETZE UND BEDEUTUNG VON CR(VI)‐IONEN
Authors: TRAYNARD PHILIPPE , MASSON JACQUELINE , DELMON B. 
Published: March 2016

AbstractEPR‐, kristallographische und Aktztvitätsuntersuchungen an Al2O3‐Cr2O3‐ Dehydrierungskatalysatoren mit M2O(M: Li‐Cs)‐ oder Tl ‐ bzw. Ba" ‐ Zusatz bestätigen, daß tetraedrisch koordinierte Cr(III)‐Ionen die katalytisch aktive Form sind.
ChemInform Abstract: ′AROMATIC′ SUBSTITUENT CONSTANTS FOR STRUCTURE‐ACTIVITY CORRELATIONS
Authors: HANSCH C. , LEO A. , UNGER S. H. , KI HWAN KIM KI HWAN KIM , NIKAITANI D. , LIEN E. J. 
Published: March 2016

Abstract235 verschiedene Substituenten an aromatischen Ringen werden hinsichtlich physikochemischer Eigenschaften (Hydrophobie, IR‐, UV‐, NMR‐Absorption) untersucht.
ChemInform Abstract: SOLVOLYTIC BEHAVIOR OF THE CIS‐ AND TRANS‐1‐TOSYLOXYCYCLOPENTANE 3,4‐EPOXIDES, THE ABSENCE OF NEIGHBORING EPOXY GROUP PARTICIPATION
Authors: HORNBACK J. M. 
Published: March 2016

Abstract3‐Cyclopentenol (I) liefert die isomeren Epoxide (IIa) und (IIIa), aus denen die Tosylate (IIb) und (IIIb) bzw. die Acetate (IIc) und (IIIc) zugänglich sind.
ChemInform Abstract: STEREOPOPULATION CONTROL PART 4, FACILITATION OF INTRAMOLECULAR CONJUGATE ADDITION OF THE HYDROXYL GROUP
Authors: BORCHARDT RONALD T. , COHEN LOUIS A. 
Published: March 2016

AbstractDas durch Reduktion mit Na‐borhydrid in Gegenwart von Bortrifluorid aus dem Cumarinderivat (I) dargestellte Chromanol (II) liefert bei der Oxidation mit N‐Bromsuccinimid (NBS) in wäßrigem Acetat‐Puffer das Hydroxypropylbenzochinon (III), wobei UV‐spektroskopisch das Hydroxydienon (VI) als Intermediärprodukt nachgewiesen wird.
ChemInform Abstract: NEW FREE‐RADICAL CYCLISATION USING REDOX‐TRANSFER INITIATING SYSTEMS
Authors: PICCARDI P. , MODENA M. , MASSARDO P. 
Published: March 2016

AbstractDie Trichlormethyl‐Verbindungen (II) bzw. (VII) bzw. (IX) reagieren in Gegenwart von Kupferchlorid, Acetonitril und Triäthylamin‐hydrochlorid (III) zu den Cyclisierungs‐Produkten (IV), bzw. (VIII), bzw. (X) und (XI).
ChemInform Abstract: MECHANISTIC ASPECTS OF THE DIENOL‐BENZENE REARRANGEMENT
Authors: VITULLO V. P. , CASHEN M. J. 
Published: March 2016

Abstract4‐Methyl‐4‐trichlormethyl‐cyclohexadienon (I) wird zum Carbinol (IIa) reduziert, aus dem die Chlorverbindung (IIb) und der Äther (IIc) zugänglich sind.
ChemInform Abstract: NITROXIDE 56. MITT. SYNTHESE DEUTERIERTER NITROXIDRADIKALE
Authors: CHIARELLI R. , RASSAT A. 
Published: March 2016

AbstractDie Synthesen der perdeuterierten Nitroxide (V), (X), (XII) bzw. (XIII) und des tertnßutans (XV) bzw. des Aminoalkohols (VIII) werden beschrieben.
ChemInform Abstract: OBSERVATION BY ELECTRON SPIN RESONANCE SPECTROSCOPY OF FREE RADICALS IN REACTIONS OF DIALKYLPLATINUM(II) COMPLEXES WITH ALKENES
Authors: HARGREAVES N. G. , PUDDEPHATT R. J. , SUTCLIFFE L. H. , THOMPSON P. J. 
Published: March 2016

AbstractDie Platin‐Komplexe (I) reagieren mit Fumarsäurediäthylester (II) und der Nitroso= Verbindung (III) bei Raumtemperatur unter Lichtausschluß zu den Radikalen (IV).
ChemInform Abstract: STEREOPOPULATION CONTROL PART 6, CONFORMATIONAL SELECTION OF ALTERNATIVE OXIDATION PATHWAYS
Authors: BORCHARDT RONALD T. , COHEN LOUIS A. 
Published: March 2016

AbstractBei der Oxidation der Dihydrocumarine (Ia) bzw. (III) mit N‐Bromsuccinimid (NBS) in H218O enthaltender Lösung entstehen die Chinone (IIa) bzw. (IV), die das Sauerstoffisotop in der Chinoncarbonylgruppe enthalten.
ChemInform Abstract: METAL‐CATALYSED OXIDATION OF ACETYLENES AND DIAZO‐KETONES
Authors: MATLIN STEPHEN A. , SAMMES PETER G. 
Published: March 2016

AbstractDie M0‐katalysierte Oxidation z.B. des Acetylens (IV) mit tert.‐Butylhydroperoxid liefert neben Benzil (V) die Benzoesäuredenvate (VI) und (VII).
ChemInform Abstract: DEUTERIUM EXCHANGE IN ALKYLPYRIDINES
Authors: PARHAM W. E. , OLSON P. E. 
Published: March 2016

AbstractSofem eine Ausbildung anionischer Strukturen wie (II) möglich ist, können alky: lierte N‐Heterocyclen wie (I), (III), (IV) oder (V) selektiv in 2‐, 4‐ und 6‐Benzyl‐Stellung deuteriert werden.
ChemInform Abstract: THE REACTION OF TRIALKYLBORANES WITH THE ALPHA‐LITHIO DERIVATIVES OF BIS(PHENYLTHIO)METHANE AND OF 1,1‐BIS(PHENYLTHIO)PENTANE, A CONVENIENT METHOD FOR THE PREPARATION OF ALDEHYDES AND KETONES
Authors: YAMAMOTO S. , SHIONO M. , MUKAIYAMA T. 
Published: March 2016

AbstractDie Bis‐(phenylthio)‐alkane (I) werden mit Butyllithium in die Lithiumverbindungen (II) umgewandelt und diese mit den Trialkylboranen (III) zu den Salzen (IV) umgesetzt, die sich unter Abspaltung von Lithiumthiophenolat in die neuen Trialkylborane (V) umwandeln.
ChemInform Abstract: FORMATION OF N‐CARBOXYMETHYL AMINO ACID FROM THE REACTION OF ALPHA‐AMINO ACID WITH GLYOXAL
Authors: CHUYEN N. V. , KURATA T. , FUJIMAKI M. 
Published: March 2016

AbstractBeim Erhitzen der Aminosäuren (I) mit Glyoxal (II) in wäßxiger acetatgepufferter Lösung bei 100°C bilden sich die Carboxymethylaminosäuren (III).
ChemInform Abstract: AN IMPROVED METHOD FOR THE SYNTHESIS OF ALIPHATIC SULFINIC ACIDS
Authors: FILBY W. G. , GUENTHER K. , PENZHORN R. D. 
Published: March 2016

AbstractDie Oxidation der Mercaptane (I) mit m‐Chlorperbenzoesäure liefert zunächst die Sulfinigsäuren (II), die weiter zu den Sulfinsäuren (III) oxidiert werden.
ChemInform Abstract: BROMODIFLUOROMETHYLPHOSPHONIUM SALTS, A CONVENIENT SOURCE OF DIFLUOROCARBENE
Authors: BURTON DONALD J. , NAAE DOUGLAS G. 
Published: March 2016

AbstractDas aus Triphenylphosphin (I) und Difluordibrommethan (II) in Triglyme entstehende Phosphoniumbromid (III) reagiert mit den Olefinen (IV) und CsF zu den Cyclopropanen (V).
ChemInform Abstract: PROPERTIES OF THE (4)ANNULENE SYSTEM, INDUCED PARAMAGNETIC RING CURRENT
Authors: MASAMUNE S. , NAKAMURA NOBUO , SUDA M. , ONA H. 
Published: March 2016

AbstractIn einem 1:1‐Gemisch aus Diäthyläther und THF entsteht bei ‐110°C aus Methyl‐ Li‐diazoacetat und Tri‐tert.‐butyl‐cyclopropeniumtetrafluoroborat das Addukt (I) in 88%iger Ausbeute, dessen Photolyse bei ‐78°C in sauerstoff‐freiem Pentan das Annulenderivat (II) ergibt.
ChemInform Abstract: SYNTHESE UND REAKTIVES VERHALTEN VON BENZYLSULFINSAEUREESTERN UND ‐AMIDEN
Authors: WENSCHUH EBERHARD , LANKAU HELMUT 
Published: March 2016

AbstractReaktion des Sulfinylchlorids (I) mit den Alkoholen (II) gibt die Sulfinsäureester (III); analog werden mit den Aminen (VII) die Amide (VIII) erhalten.
ChemInform Abstract: PARTLY REDUCED BIPHENYLS AS CENTRAL NERVOUS SYSTEM AGENTS PART 3, CIS‐ AND TRANS‐4‐ARYL‐4‐METHOXYCYCLOHEXAMINES
Authors: LEDNICER D. , EMMERT D. E. , LAHTI R. , RUDZIK A. D. 
Published: March 2016

AbstractAus den 4‐Aryl‐4‐hydroxy‐cyclohexanonen (I) entstehen die Ketale (II) und die Äther (III), die nach Hydrolyse zu (IV) zu den Carbinolen (V) und (VI) reduziert werden.
ChemInform Abstract: REACTION OF CYCLO‐OCTENYLIDENE DERIVATIVES WITH BENZENE AND BF3.(C2H5)2O
Authors: ATKINSON R. S. , GREEN R. H. 
Published: March 2016

AbstractBeim Erhitzen des Cyclooctenyliden‐esters (Ia) mit Bortrifluoridätherat in Benzol erhält man (IIa) und (IIb), aus (Ib) entsteht das Bicyclononan (III).
ChemInform Abstract: POTENTIAL BIOREDUCTIVE ALKYLATING AGENTS PART 2, ANTITUMOR EFFECT AND BIOCHEMICAL STUDIES OF NAPHTHOQUINONE DERIVATIVES
Authors: AI JENG LIN AI JENG LIN , PARDINI R. S. , COSBY L. A. , LILLIS B. J. , SHANSKY C. W. , SARTORELLI A. C. 
Published: March 2016

AbstractEine Vielzahl von 2,3‐substituierten Naphthochinonen wird nach bekannten Verfahren zur Untersuchung auf tumorhemmende Wirkung hergestellt.
ChemInform Abstract: MODIFIZIERTE WICHTERLE‐REAKTION, EIN NEUER WEG ZUR SYNTHESE VON DELTA(2)‐CYCLOHEXENONEN
Authors: KOBAYASHI M. , MATSUMOTO T. 
Published: March 2016

AbstractBeim Erhitzen der Chlorbutenylketone (I) bzw. (III) bilden sich in Lösungsmittelsystemen wie Perchlorsäure‐Ameisensäure, Bromwasserstoff‐Ameisensäure und Bromwasserstoff‐Essigsäure die cyclischen Ketone (II) bzw. (IV).
ChemInform Abstract: REACTIONS OF SOME ALPHA‐ AND BETA‐SUBSTITUTED STYRENES IN THE PRESENCE OF ETHYLALUMINUM DICHLORIDE
Authors: WOLOVSKY R. , MAOZ N. 
Published: March 2016

Abstractα‐Methylstyrol (I) liefert in Gegenwart von Äthylaluminiumdichlorid (II) die beiden Oligomeren (III) und (IV), aus β‐Methylstyrol (V) erhält man die Oligomeren (VI) und (VII), aus 1,1‐Diphenyl‐äthyle:n (VIII) entsteht das Dimere (IX), das gesättigte Diphenyläthan (X) sowie unter energischen Bedingungen das 1‐Methyl‐3,3‐diphenylindan (XI).
ChemInform Abstract: TETRACYCLINE STUDIES PART 4, SOME NOVEL CYCLISATIONS THROUGH BENZOPHENONE CARBANIONS, INCLUDING A NEW SYNTHESIS OF ANTHRAQUINONES
Authors: HASSALL CEDRIC H. , MORGAN BARRY A. 
Published: March 2016

AbstractBasenkatalysierte Cyclisierung des aus den Komponenten (I) und (II) erhältlichen Nitrils (III) liefert das Cyananthrol (IV), das zum Anthrachinon (V) oxidiert werden kann.
ChemInform Abstract: REAKTIONEN MIT DIAZOCARBONYLVERBINDUNGEN 36. MITT. UMSETZUNGEN VON ALPHA‐DIAZOKETONEN MIT DIMETHYLKETEN
Authors: RIED WALTER , KRAEMER RICHARD 
Published: March 2016

AbstractDie α‐Diazoketone (II) bzw. (IV) setzen sich mit Dimethylketen (III) unter Eliminierung von Stickstoff zu den Butenoliden (I) bzw. den Bis‐butenoliden (V) um.
ChemInform Abstract: A SYNTHESIS OF ROSENONOLACTONE FROM PODOCARPIC ACID
Authors: HANCOCK W. S. , MANDER L. N. , MASSY‐WESTROPP R. A. 
Published: March 2016

AbstractDas Epoxid (I) reagiert mit 2 oder 12 Äquivalenten Bortrifluoridätherat zu den Verbindungen (II) bzw. (II), (III) und (IVa), von denen (IVa) in (IVb) oder über (IVc) in das Dithioketal (V) übergeführt werden kann.
ChemInform Abstract: NAPHTHO(1,2‐B)THIOPHEN PART 1, PREPARATION AND ELECTROPHILIC SUBSTITUTION
Authors: CLARKE KENNETH , GREGORY DEREK N. , SCROWSTON RICHARD M. 
Published: March 2016

AbstractDie Titelverbindung (IVb) wurde in 5‐stufiger Reaktion (35% Gesamtausbeute) aus dem Tetralon (I) über Aldehyd (II), Ester (III), dessen Dehydrierung mit N‐Bromsuccinimid (88%) in CCl4, Hydrolyse zur Säure (IVa) und Decarboxylierung dargestellt.