bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limitations of the Echinococcus granulosus genome sequence assemblies for analysis of the gene family encoding the EG95 vaccine antigen
Authors: Gauci Charles G. , Alvarez Rojas Cristian A. , Chow Conan , Lightowlers Marshall W. 
Published: November 2017

AbstractEchinococcus granulosus is an important zoonotic parasite that is distributed worldwide. The EG95 vaccine was developed to assist with control of E. granulosus transmission through the parasite's livestock intermediate hosts. The vaccine is based on a recombinant antigen encoded by a gene which is a member of a multi-gene family. With the recent availability of two E. granulosus draft genomes, we sought to map the eg95 gene family to the genomes. We were unable to map unequivocally any of the eg95 gene family members which had previously been characterized by cloning and sequencing both strands of genomic DNA fragments. Our inability to map EG95-related genes to the genomes has revealed limitations in the assembled sequence data when utilized for gene family analyses. This study contrasts with the expectations expressed in often high-profile publications describing draft genomes of parasitic organisms, highlighting deficiencies in currently available genomic resources for E. granulosus and provides a cautionary note for research which seeks to utilize these genome datasets.
Brain correlates of recognition of communicative interactions from biological motion in schizophrenia
Authors: Okruszek Ł. , Wordecha M. , Jarkiewicz M. , Kossowski B. , Lee J. , Marchewka A. 
Published: November 2017

BackgroundRecognition of communicative interactions is a complex social cognitive ability which is associated with a specific neural activity in healthy individuals. However, neural correlates of communicative interaction processing from whole-body motion have not been known in patients with schizophrenia (SCZ). Therefore, the current study aims to examine the neural activity associated with recognition of communicative interactions in SCZ by using displays of the dyadic interactions downgraded to minimalistic point-light presentations.MethodsTwenty-six healthy controls (HC) and 25 SCZ were asked to judge whether two agents presented only by point-light displays were communicating or acting independently. Task-related activity and functional connectivity of brain structures were examined with General Linear Model and Generalized Psychophysiological Interaction approach, respectively.ResultsHC were significantly more efficient in recognizing each type of action than SCZ. At the neural level, the activity of the right posterior superior temporal sulcus (pSTS) was observed to be higher in HC compared with SCZ for communicativev.individual action processing. Importantly, increased connectivity of the right pSTS with structures associated with mentalizing (left pSTS) and mirroring networks (left frontal areas) was observed in HC, but not in SCZ, during the presentation of social interactions.ConclusionUnder-recruitment of the right pSTS, a structure known to have a pivotal role in social processing, may also be of importance for higher-order social cognitive deficits in SCZ. Furthermore, decreased task-related connectivity of the right pSTS may result in reduced use of additional sources of information (for instance motor resonance signals) during social cognitive processing in schizophrenia.
‘I just felt as though I had to drop something’: the implications of care for female working elder carers’ working lives
Authors: BURR VIV , COLLEY HELEN 
Published: November 2017

AbstractThis paper explores the challenges that female elder carers in the United Kingdom face in combining paid work with elder care, and the implications of this care for their current and future working lives. In-depth interviews with 11 working women from a large organisation were conducted, and five of the women were re-interviewed after a period of one year to examine any changes in their situation. The interviews revealed the precarious nature of their daily schedules, which required constant effort to maintain, the intrusion of elder care into their working lives, and the impact it had upon their career development and future aspirations. The findings provide insight into the reasons why carers, especially women, are more likely to reduce their working hours, do not take advantage of training opportunities and retire early. The findings are discussed in relation to the expectation of an extended working age and gender equality.
The impact of experiences of ageism on sexual activity and interest in later life
Authors: HEYWOOD WENDY , MINICHIELLO VICTOR , LYONS ANTHONY , FILEBORN BIANCA , HUSSAIN RAFAT , HINCHLIFF SHARRON , MALTA SUE , BARRETT CATHERINE , DOW BRIONY 
Published: November 2017

ABSTRACTExperiences of ageism are associated with poorer health outcomes. Sexual activity and interest are areas in life where the impact of ageism may also be evident as popular culture often depicts the older body as asexual, undesirable or sexually impotent. We explore the possible links between experiences of ageism and sexual activity/interest in later life using data from a study of Australians aged 60+. We explored characteristics of those who were more likely to have experienced ageism (measured using the Ageism Survey) and the relationships between experiences of ageism and measures of sexual interest/activity in later life (N = 1,817). Experiences of ageism were greater among those without a partner, unemployed participants, those with lower incomes and poorer self-rated health. Adjusting for these differences, experiences of ageism were more likely to be reported by those who had not had sex in the past two years and were not sure about their hopes/plans for sex in the future. Those who reported their sexual interest had increased or decreased since 60 also reported greater levels of ageism experience, as did those who wanted to have sex more frequently in the future. Ageism appears to impact sexual activity and interest in different ways. It is critical that social policy aims to reverse attitudes that reinforce the view of the ageist asexual and unattractive older body or person.
Finite group schemes of p-rank ≤ 1
Authors: CHANG HAO , FARNSTEINER ROLF 
Published: November 2017

AbstractLet be a finite group scheme over an algebraically closed field k of characteristic char(k) = p ≥ 3. In generalisation of the familiar notion from the modular representation theory of finite groups, we define the p-rank rkp() of and determine the structure of those group schemes of p-rank 1, whose linearly reductive radical is trivial. The most difficult case concerns infinitesimal groups of height 1, which correspond to restricted Lie algebras. Our results show that group schemes of p-rank ≤ 1 are closely related to those being of finite or domestic representation type.
How Should We Combat Corruption? Lessons from Theory and Practice
Authors: Brock Gillian 
Published: November 2017

AbstractFour recent books, taken together, offer a wealth of important insights on how we might effectively tackle corruption. All of the books’ authors agree that there is something akin to a universal understanding of what corruption is, and all dispute the idea that corruption may simply be in the eye of the beholder. However, there are also sharp disagreements—for example over whether corruption is best eliminated from the top down, or whether bottom-up approaches are more effective. If the books share one weakness, it is that they do not sufficiently emphasize the importance of getting people to believe and feel that they have fair opportunities for good lives, even after institutional and legal reforms are made. Tackling corruption involves taking seriously the substantive link between actual fair treatment and the belief that fair treatment prevails. This will require further research examining how to shift and update people’s deeply held sentiments.
Legal Protection as Competition for Jurisdiction: The Case of Refugee Protection through Law in the Past and at Present
Authors: SCHOTEL BAS 
Published: November 2017

AbstractThis article explores the structure of the legal protection of refugees in Europe today. To this end, it will contrast historical arrangements providing protection to refugees, namely church asylum in the late Middle Ages and refuge for religious minorities, with the current European refugee regime, that is the Common European Asylum System (CEAS), in particular the Dublin system. The central claim of this article is that a basic condition for the legal protection of refugees is the existence of multiple jurisdictions, which in turn caters for competition for jurisdiction. The official logic of the CEAS, however, endorses harmonization, unity and the hierarchy of jurisdictions rather than a competition between jurisdictions. This partially explains the difficulties under the CEAS in organizing the protection of refugees through law. In policy terms, this article supports calls for reconsidering the Dublin Regulation, since through the ‘single jurisdiction’ approach Dublin hampers the legal protection of refugees.
The role of telecollaboration in language and intercultural learning: A synthesis of studies published between 2010 and 2015
Authors: Çiftçi Emrullah Yasin , Savaş Perihan 
Published: November 2017

AbstractIn today’s globalized world, learning languages and developing intercultural skills are of paramount importance due to dynamic and complex global interdependencies. However, not every language student around the world has a chance to engage in face-to-face intercultural communication with people from different backgrounds. Telecollaboration offers a worthwhile opportunity by creating digital environments for language learners to communicate with people from diverse backgrounds. This qualitative meta-synthesis therefore aimed to investigate the research papers that were published between 2010 and 2015 in respect to language and intercultural learning within telecollaborative environments. Besides reporting emerging research trends among the studies, this synthesis study scrutinized recent emerging issues and observable patterns under five main themes: (1) the participants’ overall views on their telecollaborative experiences, (2) language learning through telecollaboration, (3) intercultural learning through telecollaboration, (4) the challenges experienced within the telecollaborative projects, and (5) the needs for further effective telecollaboration. Finally, this study synthesizes key emerging issues in telecollaborative projects and offers further research and practice directions in line with the current observable patterns.
Convenience-based food purchase patterns: identification and associations with dietary quality, sociodemographic factors and attitudes
Authors: Peltner Jonas , Thiele Silke 
Published: November 2017

AbstractObjectiveThe present study aimed to derive food purchase patterns considering the convenience level of foods. Associations between identified patterns and dietary quality were analysed, as well as household characteristics associated with the dietary patterns.DesignA Convenience Food Classification Scheme (CFCS) was developed. After classifying basic food groups into the CFCS, the formed groups were used to apply a factor analysis to identify convenience-based food purchase patterns. For these patterns nutrient and energy densities were examined. Using regression analysis, associations between the adherence to the patterns and household characteristic and attitude variables were analysed.SubjectsThe study used representative German food purchase data from 2011. Approximately 12 million purchases of 13 131 households were recorded in these data.ResultsThree convenience-based patterns were identified: a low-convenience, a semi-convenience and a ready-to-eat food pattern. Tighter adherence to the semi-convenience pattern was shown to result in the lowest nutrient and highest energy densities. Important factors influencing adherence to the patterns were household size, presence of children and attitudes. Working full-time was negatively associated with adherence to the low-convenience pattern and positively with the ready-to-eat pattern.ConclusionsConvenience foods were an important part of households’ food baskets which in some cases led to lower nutritional quality. Therefore, it is important to offer convenience foods higher in nutrient density and lower in energy density. Interventions targeted on enhancing cooking skills could be an effective strategy to increase purchases of unprocessed foods, which, in turn, could also contribute to an improved diet quality.
Total scatter factor for small fields in radiotherapy: a dosimetric comparison
Authors: Shamsi Qurat-ul-ain , Ahmad Buzdar Saeed , Altaf Saima , Atiq Atia , Atiq Maria , Iqbal Khalid 
Published: November 2017

AbstractPurposeSmall field dosimetry is complicated and accuracy in the measurement of total scatter factor (TSF) is crucial for dosimetric calculations, in making optimum intensity-modulated radiotherapy plans for treating small target volumes. In this study, we intended to determine the TSF measuring properties of CC01 and CC04 detectors for field sizes ranging from sub-centimetre to the centimetre fields.Material and methodsCC01 and CC04 chamber detectors were used to measure TSF for 6 and 18 MV photon beam delivered from the linear accelerator, through small fields in a water phantom. Small fields were created by collimator jaws and multi-leaf collimators separately, with field sizes ranging from 0·6 to 10 cm2and 0·5 to 20 cm2, respectively.ResultsCC01 measured TSF at all the given field sizes created by jaws and multi-leaf collimators for both 6 and 18 MV beams whereas CC04 could not measure TSF for field sizes <1 cm2due to volume averaging and perturbation effects.ConclusionCC01 was shown to be effective for measurement of TSF in sub-centimetre field sizes. CC01 can be employed to measure other dosimetric quantities in small fields using different energy beams.
Portuguese culture and legal consciousness: a discussion of immigrant women's perceptions of and reactions to domestic violence
Authors: Graca Sofia 
Published: November 2017

AbstractThis paper uses legal consciousness to discuss the influence of Portuguese culture on women's perceptions of and reactions to domestic violence. It is based on an in-depth small-scale study of Portuguese women living in England, and proposes that culture is central in shaping their behaviour, regardless of whether they experienced violence or not. The cultural characteristics that influence women the most are analysed here under the themes of ‘familism’, ‘shame and community pressure’ and ‘acculturation’. These do not operate all at the same level and their influence can change according to structural and individual circumstances. As such, the paper suggests that immigrant women's perceptions of and reactions to domestic violence can only be fully understood by articulating national culture with other structural and individual variables; this will enable a multilayered and situated understanding of women's legality that avoids a simplistic attribution of their behaviour to national or ethnic provenance.
Simple or complex? A case study of physical and mental health co-morbidity
Authors: Bennett Sophie D. , Heyman Isobel , Varadkar Sophia , Coughtrey Anna E. , Shafran Roz 
Published: November 2017

AbstractPeople with epilepsy are significantly more likely to have a mental health disorder than those without a chronic illness. The reasons for this are multiple but may include the mental health difficulties being perceived as complex due to the presence of a chronic illness. In part due to the apparent complexity of the co-occurring physical and mental illness, many are not offered evidence-based treatment (EBT) for the mental health disorder. There is little guidance to inform clinicians about the interventions to use to treat mental health disorders in people with epilepsy. The present paper reports a case of treatment for depression using a standard EBT in a young person with epilepsy. The patient also had clinically significant symptoms of anxiety and an eating disorder and would be considered ‘complex’ according to standard criteria. The intervention, however, was relatively simple and was delivered as guided self-help via 10 weekly telephone calls of approximately 30 minutes duration, and two follow-up calls at one month and three months post-intervention. Self-report and parent-report questionnaire measures were completed before and after the intervention, and at both follow-up time points. A blind-rated online diagnostic interview measure was also completed before and after the intervention. The young person and her family also completed a qualitative interview of their experiences of the intervention. This simple intervention was effective in working towards the client's goals, although pre–post measurement on standard measures was variable. This interesting case raises questions about whether patients with mental and physical comorbidities are complex, or just perceived as complex.
Oil, Islam, and the Middle East: An Empirical Analysis of the Repression of Religion, 1980–2013
Authors: Albertsen Daniel , de Soysa Indra 
Published: November 2017

AbstractThere is a lively debate on the relative impacts of Islam, oil wealth, and Middle Eastern institutional legacies regarding democratization and the spread of liberal values. We examine this issue using religious repression. We argue that oil-wealthy rulers use religious monopoly to control dissent. Our results show that oil wealth increases religious repression above the effects of Muslim dominance and a host of sundry controls. The Middle East and North Africa region seems to matter more than Islam. Interestingly, the conditional effect of oil and the Middle East and North Africa region is positive on religious freedom. The data suggest that several Gulf monarchies have more religious freedoms than other Muslim dominant states, such as Saudi Arabia and Iran, or even Israel and Jordan. The worst religious repression is among oil producers in Central Asia. The results are robust to a host of intervening factors, different measures of oil wealth, alternative data on religious freedom, and estimating method.
Epithelial-to-mesenchymal transition in gallbladder cancer: from clinical evidence to cellular regulatory networks
Authors: Xu Sunwang , Zhan Ming , Wang Jian 
Published: November 2017

AbstractGallbladder cancer (GBC), with late diagnosis, rapid disease progression and early metastasis, is a highly aggressive malignant tumor found worldwide. Patients with GBC have poor survival, low curative resection rates and early recurrence. For such a lethal tumor, uncovering the mechanisms and exploring new strategies to prevent tumor progression and metastasis are critically important. Epithelial-to-mesenchymal transition (EMT) has a prominent role in the early steps of tumor progression and metastasis by initiating polarized epithelial cell transition into motile mesenchymal cells. Accumulating evidence suggests that EMT can be modulated by the cooperation of multiple mechanisms affecting common targets. Signaling pathways, transcriptional and post-transcriptional regulation and epigenetic alterations are involved in the stepwise EMT regulatory network in GBC. Loss of epithelial markers, acquisition of mesenchymal markers and dysregulation of EMT-inducing transcription factors (EMT-TFs) have been observed and are associated with the clinicopathology and prognosis of GBC patients. Therefore, EMT may be a detectable and predictable event for predicting GBC progression and metastasis in the clinic. In this review, we will provide an overview of EMT from the clinical evidence to cellular regulatory networks that have been studied thus far in clinical and basic GBC studies.
Expressed fusion gene landscape and its impact in multiple myeloma
Authors: Cleynen A. , Szalat R. , Kemal Samur M. , Robiou du Pont S. , Buisson L. , Boyle E. , Chretien M. L. , Anderson K. , Minvielle S. , Moreau P. , Attal M. , Parmigiani G. , Corre J. , Munshi N. , Avet-Loiseau H. 
Published: November 2017

AbstractMultiple myeloma is a plasma cell malignancy characterized by recurrent IgH translocations and well described genomic heterogeneity. Although transcriptome profiles in multiple myeloma has been described, landscape of expressed fusion genes and their clinical impact remains unknown. To provide a comprehensive and detailed fusion gene cartography and suggest new mechanisms of tumorigenesis in multiple myeloma, we performed RNA sequencing in a cohort of 255 newly diagnosed and homogeneously treated multiple myeloma patients with long follow-up. Here, we report that patients have on average 5.5 expressed fusion genes. Kappa and lambda light chains and IgH genes are main partners in a third of all fusion genes. We also identify recurrent fusion genes that significantly impact both progression-free and overall survival and may act as drivers of the disease. Lastly, we find a correlation between the number of fusions, the age of patients and the clinical outcome, strongly suggesting that genomic instability drives prognosis of the disease.
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice
Authors: De Logu Francesco , Nassini Romina , Materazzi Serena , Carvalho Gonçalves Muryel , Nosi Daniele , Rossi Degl’Innocenti Duccio , Marone Ilaria M. , Ferreira Juliano , Li Puma Simone , Benemei Silvia , Trevisan Gabriela , Souza Monteiro de Araújo Daniel , Patacchini Riccardo , Bunnett Nigel W. , Geppetti Pierangelo 
Published: November 2017

AbstractIt is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and oxidative stress, whereas TRPA1 silencing in Schwann cells reduced both allodynia and neuroinflammation. Activation of Schwann cell TRPA1 evoked NADPH oxidase 1 (NOX1)-dependent H2O2release, and silencing or blocking Schwann cell NOX1 attenuated nerve injury-induced macrophage infiltration, oxidative stress and allodynia. Furthermore, the NOX2-dependent oxidative burst, produced by macrophages recruited to the perineural space activated the TRPA1–NOX1 pathway in Schwann cells, but not TRPA1 in nociceptors. Schwann cell TRPA1 generates a spatially constrained gradient of oxidative stress, which maintains macrophage infiltration to the injured nerve, and sends paracrine signals to activate TRPA1 of ensheathed nociceptors to sustain mechanical allodynia.
Nematic superconducting state in iron pnictide superconductors
Authors: Li Jun , Pereira Paulo J. , Yuan Jie , Lv Yang-Yang , Jiang Mei-Ping , Lu Dachuan , Lin Zi-Quan , Liu Yong-Jie , Wang Jun-Feng , Li Liang , Ke Xiaoxing , Van Tendeloo Gustaaf , Li Meng-Yue , Feng Hai-Luke , Hatano Takeshi , Wang Hua-Bing , Wu Pei-Heng , Yamaura Kazunari , Takayama-Muromachi Eiji , Vanacken Johan , Chibotaru Liviu F. , Moshchalkov Victor V. 
Published: November 2017

AbstractNematic order often breaks the tetragonal symmetry of iron-based superconductors. It arises from regular structural transition or electronic instability in the normal phase. Here, we report the observation of a nematic superconducting state, by measuring the angular dependence of the in-plane and out-of-plane magnetoresistivity of Ba0.5K0.5Fe2As2 single crystals. We find large twofold oscillations in the vicinity of the superconducting transition, when the direction of applied magnetic field is rotated within the basal plane. To avoid the influences from sample geometry or current flow direction, the sample was designed as Corbino-shape for in-plane and mesa-shape for out-of-plane measurements. Theoretical analysis shows that the nematic superconductivity arises from the weak mixture of the quasi-degenerate s-wave and d-wave components of the superconducting condensate, most probably induced by a weak anisotropy of stresses inherent to single crystals.