bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explore the effect of magnesium oxide nanoparticles decorated graphene oxide hybrid nanofillers reinforced polyaniline ternary nanocomposites on optical, thermal, and dielectric properties
Authors: Mohapatra Pooja , Behera Shreelata , Sahoo Saleja , Mishra Annada , Dalpati Archana , Shubhadarshinee Lipsa , Jali Bigyan Ranjan , Mohapatra Priyaranjan , Barick Aruna Kumar 
Published: October 2024

Abstract
The Neem (Azadirachta indica) leaves utilized for the synthesis of magnesium oxide nanoparticles (MgONPs) are readily available and pose little risk of harm. The MgONPs@GO hybrid nanofillers are synthesized through in situ method and is reinforced with polyaniline (PANI) to enhance its electrical characteristics and thermal stability. The UV-visible spectroscopy demonstrates the formation of a charge transfer complex in the PANI/MgONPs@GO ternary nanocomposites. The presence of functional groups in the PANI/MgONPs@GO ternary nanocomposites was detected using Fourier transform infrared (FTIR) spectroscopy. The crystalline phases of the PANI/MgONPs@GO ternary nanocomposites were validated using x-ray diffraction (XRD) investigation. The scanning electron microscopy (SEM) technique was used to investigate the nanostructured morphology of the PANI/MgONPs@GO ternary nanocomposites. The thermogravimetric analysis (TGA) revealed that the PANI/MgONPs@GO ternary nanocomposites exhibited greater thermal stability compared to the pure PANI. The AC conductivity (σ
ac), dielectric permittivity (ε′), and dielectric loss (tanδ) of PANI/MgONPs@GO ternary nanocomposites exhibit a substantial increase compared to pure PANI.
Transitive–intransitive alignment
Authors: Creissels Denis 
Published: October 2024

Abstract
The topic of this chapter is the alignment in the coding properties of the core nominal terms of transitive and intransitive clauses. Section 5.1 discusses the relationship between types of transitive coding as defined in the last section of Chapter 4 and types of alignment in the coding characteristics of the core nominal terms of transitive and intransitive clauses. Section 5.2 is an introduction to participant coding systems involving various kinds of violations of the Obligatory Coding Principle, discussed in more detail in sections 5.3 to 5.7. The last two sections of this chapter are devoted to various types of historical changes that may have an incidence on core term coding, and consequently may result in violations of the Obligatory Coding Principle.
The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21 years
Authors: Mehrabi Fereshteh , Pomeroy Mary Louise , Cudjoe Thomas K M , Jenkins Emerald , Dent Elsa , Hoogendijk Emiel O 
Published: October 2024

Abstract

Background
It is unclear whether social isolation and loneliness may precede frailty status or whether frailty may precipitate social isolation and loneliness. We investigated the reciprocal and temporal sequence of social isolation, loneliness, and frailty among older adults across 21 years.

Methods
We used seven waves of the Longitudinal Aging Study Amsterdam from 2302 Dutch older adults (M = 72.6 years, SD = 8.6, 52.1% female) ages 55 or older. Using random intercept cross-lagged panel models, we investigated between- and within-person associations of social isolation and loneliness with frailty. Frailty was measured using the Frailty Index. Loneliness was measured using the 11-item De Jong Gierveld Loneliness Scale. Social isolation was measured using a multi-domain 6-item scale.

Results
Social isolation and loneliness were weakly correlated across waves. At the between-person level, individuals with higher levels of frailty tended to have higher levels of social isolation but not loneliness. At the within-person level, the cross-lagged paths indicated that earlier frailty status predicted future social isolation and loneliness over time. However, prior social isolation was not associated with subsequent frailty except at time point 5 (T5). Loneliness at specific time points (T1, T4 and T6) predicted greater frailty at later time points (T2, T5 and T7). The results also supported reciprocal and contemporaneous relations between social isolation, loneliness and frailty.

Conclusions
Social isolation and loneliness are potential outcomes of frailty. Public health policies and health practitioners should prioritise interventions targeting social connection among older adults with pre-frailty or frailty.
Validity of the Pregnancy Physical Activity Questionnaire Short Form (PPAQ-SF)
Authors: Park Susan , Marcotte Robert , Staudenmayer John , Sirard John , VanKim Nicole , Pekow Penelope , Strath Scott , Freedson Patty , Chasan-Taber Lisa 
Published: October 2024

Abstract
To develop and evaluate the validity of the Pregnancy Physical Activity Questionnaire-Short Form (PPAQ-SF). A prospective cohort of participants (N=50) completed the updated PPAQ (long-form) and wore an ActiGraph for 7 days on the nondominant wrist in early, mid, and late pregnancy. The top ten questions with the highest relative contribution to the between-person variance in PPAQ-assessed total MET-hours/day were selected. Internal validity was evaluated using the ActiGraph and the updated PPAQ (long-form) within the current dataset. Validity was also assessed in an external validation dataset of 222 pregnant participants using the updated and original PPAQ (long-forms). Spearman correlations between the PPAQ-SF and ActiGraph estimates of MVPA MET-hours/day were r = 0.34 (95% CI 0.18-0.48) for overall pregnancy and ranged from 0.21 (95% CI -0.07-0.47) in early pregnancy to 0.49 (95% CI 0.23-0.69) in mid-pregnancy. In the external validation dataset, correlations between the PPAQ-SF and the PPAQ (long forms) estimates of MVPA MET-hours/day were statistically significant across pregnancy (r=0.94-0.99). Reproducibility ranged from 0.35 in early pregnancy to 0.77 in mid pregnancy. In summary, the PPAQ-SF can provide a time-efficient measure of MVPA during pregnancy with acceptable validity; reproducibility was reasonable in mid-pregnancy.
Association of prey quality with environmental odors in the foraging behavior of Pardosa milvina
Authors: Shannon Hailey C , Rypstra Ann L 
Published: October 2024

Abstract
Modulation of predatory behaviors based on prey profitability can improve overall foraging efficiency by allocating energy reserves towards more valuable prey. Should the value of prey vary predictably across the landscape, predators could also benefit from the utilization of environmental cues to inform their foraging decisions. Here, we present data on context-dependent foraging behaviors of the wolf spider Pardosa milvina (Araneae: Lycosidae). Spiders underwent testing during which subjects were alternately provided cricket prey coated with either a favorable (sucrose) or unfavorable (quinine) solution. Each prey type was paired with 1 of 2 environmental odors such that one odor was always predictive of unfavorable prey and the other was always predictive of favorable prey. We found that P. milvina reduced their attacks over time while differing significantly in behavior towards the 2 prey types. The rate of nonresponses towards the unfavorable prey increased significantly over time compared to the favorable prey, suggesting that spiders were avoiding the former. Our findings indicate that P. milvina can differentiate between environmental odor cues associated with prey type. Additionally, we report on a novel prey handling behavior where spiders would repeatedly drag unfavorable prey along the arena floor between bouts of cheliceral grooming. We propose this behavior may have served to remove quinine from the prey.
Age, sex, and temperature shape off-territory feeder use in black-capped chickadees
Authors: LaRocque Megan , Wijmenga Jan J , Mathot Kimberley J 
Published: October 2024

Abstract
Spatial ecology tends to focus on average movement patterns within animal groups; however, recent studies highlight the value of considering movement decisions both within and among individuals. We used a marked population of black-capped chickadees (Poecile atricapillus), to assess the causes and consequences of within- and among-individual differences in chickadee space use. Individuals that used feeders in addition to their most-visited “core feeder” were defined as engaging in off-territory feeder use. We found that females were more likely than males to visit off-territory feeders as ambient temperatures decrease and energetic demands increase. This may be due to sex-related differences in dominance, where males which are the dominant sex in chickadees, have priority access to feeders, while females must increase their foraging areas to meet higher energetic demand. We also found that independent of temperature, adult males were less likely than juvenile males and both juvenile and adult females to forage off-territory. We suggest that this may be due to age-specific benefits of space use in males, where un-paired juvenile males may increase feeder exploration to gain information about potential mates. Finally, we found that chickadees that had a higher propensity to visit off-territory feeders were less likely to survive to the next fall. Overall, our results suggest that dominance hierarchies and individual energetics impact within- and among-individual variation in off-territory feeder use. We provide suggestions for future studies to further investigate fitness-related consequences of within- and among-individual variation in space use.
Composite dyadic models for spatio-temporal data
Authors: Schwob Michael R , Hooten Mevin B , Narasimhan Vagheesh 
Published: October 2024

ABSTRACT
Mechanistic statistical models are commonly used to study the flow of biological processes. For example, in landscape genetics, the aim is to infer spatial mechanisms that govern gene flow in populations. Existing statistical approaches in landscape genetics do not account for temporal dependence in the data and may be computationally prohibitive. We infer mechanisms with a Bayesian hierarchical dyadic model that scales well with large data sets and that accounts for spatial and temporal dependence. We construct a fully connected network comprising spatio-temporal data for the dyadic model and use normalized composite likelihoods to account for the dependence structure in space and time. We develop a dyadic model to account for physical mechanisms commonly found in physical-statistical models and apply our methods to ancient human DNA data to infer the mechanisms that affected human movement in Bronze Age Europe.
Oesophageal injury mimicking a tubular congenital oesophageal duplication—a diagnostic dilemma: a case report
Authors: Shrivastava Shreya , Joshi Priscilla , Pinglikar Shriyash 
Published: October 2024

Abstract
Intramural oesophageal dissection (IED) is an uncommon condition in newborns marked by the separation of the mucosal and submucosal layers of the oesophageal wall, both transversely and longitudinally, which may or may not involve perforation. A neonate presented at 26 h of life with poor respiratory effort and lethargy. She was intubated and was put on mechanical ventilation. Radiograph of the neonate suggested malpositioned endotracheal tube. The fluoroscopic dye-study indicated gastroesophageal oesophageal reflux disease and nothing significant. On limited CT contrast study of thorax, a tubular structure was seen running just parallel to the oesophagus extending from the T2 to the T9 levels. Possibilities of a oesophageal duplication/IED were considered. The neonate underwent an endoscopy and gastrostomy on day of life (DOL) 9. On follow up at 3 months a repeat limited CT study was done with instillation of water-soluble contrast. The previously seen tubular structure running parallel to the oesophagus was no longer seen. This finding suggested a healed IED. This case report emphasizes the significance of multimodality imaging in the diagnosis of this condition.
Pore design of POM@MOF hybrids for enhanced methylene blue capture
Authors: Miyazaki Shotaro , Ogiwara Naoki , Nagasaka Cocoro A , Takiishi Kanta , Inada Miki , Uchida Sayaka 
Published: October 2024

Abstract
Adsorption of methylene blue from aqueous effluents is a key technique to treat wastewater discharge from chemical industries. Toward methylene blue adsorption, porous metal–organic frameworks have been promising owing to their high surface areas and tunable porosity. The incorporation of polyoxometalates (POMs) into metal–organic frameworks has been found to facilitate methylene blue adsorption due to electrostatic interactions between the anionic polyoxometalate and the cationic methylene blue. However, it remains unclear how the customizable pore of POM@MOF hybrids affects the capture of methylene blue. In this work, we study the effect of the size and environment of metal–organic frameworks on the property of methylene blue capture for [Zr6O4(OH)4(1,4-benzenedicarboxylate)6] (UiO-66) embedding an α-Keggin-type polyoxometalate [α-SiW12O40]4− (SiW12). Tuning pore size and environment based on ligand engineering of the metal–organic frameworks suggests that (i) lengthening the organic linkers and (ii) functionalization of the linker with −NO2 groups could enhance the methylene blue uptakes. Notably, an increase in the loading amounts of SiW12 on UiO-66 functionalized with −NO2 groups led to outstanding methylene blue capture, comparable to that of representative zeolites such as ZSM-5 and zeolite Y.
Prevalence of Drug Resistance Associated Substitutions in Persons With Chronic Hepatitis C Infection and Virological Failure Following Initial or Re-treatment With Pan-genotypic Direct-Acting Antivirals: A Systematic Review and Meta-analysis
Authors: Inzaule Seth , Easterbrook Philippa , Latona Ashley , Ford Nathan P , Irving William , Matthews Philippa C , Vitoria Marco , Duncombe Chris , Giron Amalia , McCluskey Suzanne , Lesi Olufunmilayo , Tchamgoue Serge , Halford Rachel , Adda Danjuma , Thomson Emma , Dusheiko Geoff , Jordan Michael R 
Published: October 2024

Abstract

Background
The advent of short-course, curative treatment with direct-acting antivirals (DAA) has given promise for the global elimination of hepatitis C virus (HCV) infections by 2030. Virological failure occurs in 2%–12% of persons receiving curative DAA treatment and may be presaged by pre-existing polymorphisms or result from selection of drug resistant variants during therapy.

Methods
We conducted a systematic review to assess the prevalence of HCV resistance associated substitutions (RAS) among individuals with chronic hepatitis C infection who had virological failure following initial or re-treatment with pan-genotypic DAA regimens. We included 34 and 22 studies assessing RAS in people with virological failure published between January 2014 and July 2023. Pooled RAS prevalence was estimated using random-effects meta-analysis.

Results
The pooled prevalence of RAS in people with virological failure following initial DAA treatment was 78.0% (95% confidence interval [CI]: 62.0–92.0) for sofosbuvir/velpatasvir, 81.0% (95% CI: 67.0–93.0) for sofosbuvir/daclatasvir, and 79.0% (95% CI: 70.0–87.0) for glecaprevir/pibrentasvir, with a high prevalence of resistance to the NS5A inhibitors. Among those with virological failure following re-treatment regimens, RAS were present in 93.0% (95% CI: 83.0–99.0) for sofosbuvir/velpatasvir/voxilepravir and in 100% (95% CI: 92.0–100) for glecaprevir/pibrentasvir, with resistance driven by RAS to NS5A inhibitors.

Discussion
At least 1 RAS is present in a high proportion of the few individuals with virological failure following initial or re-treatment with pan-genotypic DAA regimens. There is a need for ongoing surveillance for DAA-associated resistance, to assess risk factors for their development and clinical impact to inform best practice strategies for re-treatment.
Development of an Electronic Clinical Surveillance Measure for Unnecessary Rapid Antibiotic Administration in Suspected Sepsis
Authors: Taylor Stephanie Parks , Palakshappa Jessica A , Chou Shih-Hsiung , Gibbs Kevin , King Jessie , Patel Nikhil , Kowalkowski Marc 
Published: October 2024

Abstract

Background
Substantial efforts focus on monitoring and reducing delays in antibiotic treatment for sepsis, but little has been done to characterize the balancing measure of sepsis overtreatment. We aimed to establish preliminary validity and usefulness of electronic health record (EHR) data–derived criteria for sepsis overtreatment surveillance (SEP-OS).

Methods
We evaluated adults with potential sepsis (≥2 Systemic Inflammatory Response Syndrome criteria within 6 hours of arrival) presenting to the emergency department of 12 hospitals, excluding patients with shock. We defined SEP-OS as the proportion of patients receiving rapid IV antibiotics (≤3 hours) who did not ultimately meet the Centers for Disease Control Adult Sepsis Event “true sepsis” definition. We evaluated the frequency and characteristics of patients meeting overtreatment criteria and outcomes associated with sepsis overtreatment.

Results
Of 113 764 eligible patients, the prevalence of sepsis overtreatment was 22.5%. The measure met prespecified criteria for reliability, content, construct, and criterion validity. Patients classified by the SEP-OS overtreatment criteria had higher median antibiotic days (4 days [IQR, 2–5] vs 1 day [1–2]; P &lt; .01), longer median length of stay (4 days [2–6] vs 3 days [2–5]; P &lt; .01), higher hospital mortality (2.4% vs 2.1%; P = .01), and higher frequency of Clostridioides difficile infection within 6 months of hospital discharge (P &lt; .01) compared with “true negative” cases.

Conclusions
We developed a novel, valid EHR metric for clinical surveillance of sepsis overtreatment. Applying this metric to a large cohort of potential sepsis patients revealed a high rate of overtreatment and provides a useful tool to inform sepsis quality-improvement targets.
The benefit of reduced serum phosphate levels depends on patient characteristics: a nationwide prospective cohort study
Authors: Goto Shunsuke , Hamano Takayuki , Fujii Hideki , Taniguchi Masatomo , Abe Masanori , Nitta Kosaku , Nishi Shinichi 
Published: October 2024

ABSTRACT

Background
In cohort studies of hyperphosphatemic hemodialysis patients, reduced serum phosphate levels have been linked to a lower mortality risk. To investigate whether this benefit is influenced by patient characteristics, we calculated the number needed to be exposed (NNE), stratified by patient characteristics.

Methods
In this 9-year prospective cohort study using the nationwide Japanese registry, we enrolled 78 256 hemodialysis patients aged 18 years or older. We investigated the relationship between time-averaged (TA) phosphate levels and mortality due to cardiovascular disease (CVD) using Cox proportional models. We estimated the 1-year NNE for CVD death in patients with baseline serum phosphate levels ≥6.0 mg/dL and exposure to TA phosphate levels decreasing to 3.5–&lt;5.0 mg/dL using mixed-effects Poisson models.

Results
The hazard ratio of CVD mortality decreased linearly with lower serum TA phosphate levels in those with prior atherosclerotic CVD (ACVD) or diabetic nephropathy (DN) but plateaued with serum phosphate &lt;5.0 mg/dL in those without. The hazard ratios (95% confidence interval) for phosphate ≥7.0 mg/dL compared with 3.5–&lt;3.9 mg/dL were 1.58 (1.38–1.81) in those with prior ACVD, 1.91 (1.68–2.17) in those without, 1.87 (1.63–2.16) in those with DN and 1.65 (1.46–1.87) in those without. However, the NNE for one more person to benefit (NNEB) for CVD death was lower in patients with a history of ACVD than in those without (61 vs 118). Patients with DN had lower NNEB than those without (69 vs 113). In patients with TA albumin ≥3.8 g/dL, older patients had lower NNEB, while patients with TA albumin &lt;3.45 g/dL showed no benefit in some groups, including the elderly.

Conclusions
The benefit of intensive phosphate management may be pronounced in patients with a history of ACVD or DN. A comprehensive approach that considers both age and nutritional status may be necessary when managing serum phosphate levels.
Crohn’s Disease and Ulcerative Colitis Share 2 Molecular Subtypes With Different Mechanisms and Drug Responses
Authors: Wang Jing , Guay Heath , Chang Dan 
Published: October 2024

Abstract

Background and Aims
Several therapies have been approved to treat Crohn’s disease (CD) and ulcerative colitis (UC), indicating that both diseases may share the same molecular subtypes. The aim of this study is to identify shared patient subtypes with common molecular drivers of disease.

Methods
Five public datasets with 406 CD and 421 UC samples were integrated to identify molecular subtypes. Then, the patient labels from 6 independent datasets and 8 treatment datasets were predicted for validating subtypes and identifying the relationship with response status of corticosteroids, infliximab, vedolizumab, and ustekinumab.

Results
Two molecular subtypes were identified from the training datasets, in which CD and UC patients were relatively evenly represented in each subtype. We found 6 S1-specific gene modules related to innate/adaptive immune responses and tissue remodeling and 9 S1-specific cell types (cycling T cells, Tregs, CD8+ lamina propria, follicular B cells, cycling B cells, plasma cells, inflammatory monocytes, inflammatory fibroblasts, and postcapillary venules). Subtype S2 was associated with 3 modules related to metabolism functions and 4 cell types (immature enterocytes, transit amplifying cells, immature goblet cells, and WNT5B+ cells). The subtypes can be replicated in 6 independent datasets based on a 20-gene classifier. Furthermore, response rates to 4 treatments in subtype S2 were significantly higher than those in subtype S1.

Conclusions
This study discovered and validated a robust transcriptome-based molecular classification shared by CD and UC and built a 20-gene classifier. Because 2 subtypes have different molecular mechanisms and drug response, our classification may aid interpretation of heterogeneous molecular and clinical information in inflammatory bowel disease patients.
Preformed mincle dimers stabilized by an interchain disulfide bond in the neck region
Authors: Liu Yu , Drickamer Kurt , Taylor Maureen E 
Published: October 2024

Abstract
The sugar-binding receptor mincle stimulates macrophages when it encounters surface glycans on pathogens, such as trehalose dimycolate glycolipid in the outer membrane of mycobacteria. Binding of oligosaccharide ligands to the extracellular C-type carbohydrate-recognition domain (CRD) in mincle initiates intracellular signaling through the common Fc receptor γ (FcRγ) adapter molecule associated with mincle. One potential mechanism for initiation of signaling involves clustering of receptors, so it is important to understand the oligomeric state of mincle. Affinity purification of mincle from transfected mammalian cells has been used to show that mincle exists as a pre-formed, disulfide-linked dimer. Deletion of cysteine residues and chemical crosslinking further demonstrate that the dimers of mincle are stabilized by a disulfide bond between cysteine residues in the neck sequence that links the CRD to the membrane. In contrast, cysteine residues in the transmembrane region of mincle are not required for dimer formation or association with FcRγ. A protocol has been developed for efficient production of a disulfide-linked extracellular domain fragment of mincle in a bacterial expression system by appending synthetic dimerization domains to guide dimer formation in the absence of the membrane anchor.