bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selección de cepas productoras de enzimas ligninolíticas nativas del Valle del Yaqui
Authors: Maldonado Bustamante Sara Roxana , Mondaca Fernández Iram , Reyes Caro Raúl Benjamín , Gámez Gutiérrez Luis Angel , De los Santos Villalobos Sergio , Meza  Montenegro María Mercedes , Balderas Cortés José De Jesús 
Published: September 2017

Introducción: Las fibras lignocelulósicas están compuestas por tres polímeros: celulosa, hemicelulosa y lignina. El biopulpeo es un pretratamiento, previo al proceso de pulpeo físico químico, cuyo fin es lograr la deslignificación parcial del complejo lignocelulósico por la acción de hongos, debido a que los hongos tienen un complejo enzimático formado por: ligno peroxidasas (LiP), lacasas (Lac), manganeso peroxidasas (MnP), y xilanasas (Xil). Las cepas nativas tienen la habilidad de deslignificar el material lignocelulósico como paja de trigo o madera, entre otros.Método: Se trabajó con diez cepas de la colección COLMENA del Laboratorio de Biotecnología del Recurso Microbiano del Instituto Tecnológico de Sonora. La selección de cepas se realizó escogiendo las que presentaron mayor índice de potencia (I.P.), obtenido a través de la comparación del halo de actividad enzimática contra el halo de crecimiento de la cepa, a los 14 días de incubación utilizando el software Image J 1.44.Resultados: De las diez cepas evaluadas, la mejor para la producción de LiP fue TSM35 con un I.P. de 3.83±0.29, para Lac y Xil; la cepa TSO46 obtuvo valores de con un I.P. de 20.37±2.70 y 1.38±0.00 respectivamente. Con este estudio se determinó el potencial de incorporar cepas nativas para el pretratamiento de biopulpeo previo a un un proceso de deslignificación físico químico.Discusiones o Conclusiones: Se logró determinar que tres cepas tienen actividad ligninolítica en medio sólido por excreción de LiP, Lac y Xil, por lo que tienen potencial para incorporarlos como pretratamiento en un proceso de deslignificación.
Numerical investigation of pipe length determination in branched systems by transient tests
Authors: Capponi Caterina , Ferrante Marco 
Published: September 2017

AbstractTransients are used as a diagnostic tool for pressurized pipes due to their capabilities to acquire and transmit information about system status. To interpret such information in complex systems, models obtained by the integration of the governing equations in the frequency domain are used, since they are computationally efficient and reliable. These models do not require a regular spatial grid for integration and introduce the pipe lengths as parameters. In this paper a calibration procedure based on this particular feature is introduced, to determine a basic item of information that can be lost about the water distribution system, that is the length of the pipes. The network admittance matrix method is implemented and its numerical efficiency allows the investigation of the calibration optimization function on a regular grid in the parameter space. The calibration is tested using in series a genetic and the Nelder–Mead algorithms, considering both elastic and viscoelastic material pipes. The results of the presented numerical investigation allow some insights into the existence of the solution and into the shape of the optimization function.
Effect and Mechanism of Curcumin on EZH2 - miR-101 Regulatory Feedback Loop in Multiple Myeloma
Authors: Wu Chuanqing , Ruan Tuo , Liu Weizhen , Zhu Xiaojie , Pan Juan , Lu Wen , Yan Chen , Tao Kaixiong , Zhang Weikang , Zhang Chun 
Published: September 2017

Background:
Multiple myeloma is the second most prevalent hematologic malignancy and thought to
be incurable. Therefore, it’s urgent to find new drugs for treatment. Some experiments have shown that curcumin
might have great potential in treating multiple myeloma, while the mechanism is still unknown. EZH2 and
SUZ12 are the core proteins in PRC2 and their expressions are increased in various human cancers, including the
poor prognostic multiple myeloma. Meanwhile, the regulation of miRNAs and EZH2 has been demonstrated in
other cancer researches, like lung cancer, pancreatic cancer, leukemia and so on.

Objective:
To reveal the mechanism behind the anti-tumor effect of cucurmin in multiple myeloma.

Method:
The effect of curcumin on the growth of MM cells was studied by MTT assay in the MM cell lines
RPMI8226 and U266. Apoptosis was measured by Annexin V-FITC/PI double staining method. Western blotting,
RT-PCR and luciferase activity assay were used to assess the expression of EZH2, SUZ12, miR-101 and downstream
proteins such as E-cadherin, MMP9, c-Myc, cyclin D3, CDK4 and CDK6.

Results:
Curcumin could significantly inhibite the proliferation of MM cells in a time- and concentrationdependent
manner. Curcumin induced apoptosis by inhibiting the expression of EZH2, and the apoptosis rates
were 16.42% and 25.62% when the RPMI8226 cells incubated with 5 and 10 µmol/L of curcumin. For U266
cells, the apoptosis rates were 15.25% and 21.28%. The up-regulation of miR-101 led to the lower expression of
EZH2. In adverse, the expression of EZH2 induced lower expression of miR-101. The down-stream proteins of
miR-101 were regulated by curcumin and EZH2 at the same time.

Conclusion:
Our experiments verified that the effect and mechanism of curcumin on multiple myeloma is via
EZH2 – miR-101 regulatory feedback loop, which would lead us to a new way of investigating multiple myeloma
and come up with new therapies in treating the disease.
Ephedrines as Chiral Auxiliaries in Enantioselective Alkylation Reactions of Acyl Ephedrine Amides and Esters: A Review
Authors: Cruz Alejandro , Padilla-Martínez Itzia I. , Bautista-Ramirez Maria E. 
Published: September 2017

Background:
In modern chemistry, the asymmetric synthesis for the preparation of high purity
chiral compounds to be used as pharmaceuticals or additives in foods have been of capital importance. Chiral
auxiliary reagents are used to control the stereochemistry of the reaction in the generation of new chiral compounds,
in this context, Ephedra compounds (ephedrines and pseudoephedrines) and some of their derivatives
have been broadly used as chiral ligands in catalysis or chiral inductors in asymmetric synthesis.

Objective:
This review focuses on recent progress in the use of ephedra compounds and their N-substituted derivatives
as chiral auxiliaries in the area of asymmetric synthesis, via the alkylation reaction of the enolates derived
from their corresponding N-Acyl or O-Acyl derivatives, in the C-C bond formation.

Conclusion:
A vast amount of work has been done about the use of ephedra compounds in asymmetric synthesis
area, in general, it was found that pseudoephedrines are much more effective than ephedrines and are preferred
as chiral auxiliaries in the asymmetric alkylation of the corresponding N-acyl amides or O-Acyl esters.
Alkylation with alkyl halides requires the use of more than 4 equivalents of LiCl to accelerate the alkylation
rate and to complete the reaction without effecting the diastereoselectivity of the process. In contrast, the use of
secondary alkyl halides was found to make the reaction very slow. Furthermore, a lot of work about the alkylation
reaction in the opening of epoxides and aziridines, aldolic condensation, Manich reaction, addition of nucleophiles
to α,β-unsaturated ephedrine amides and Michael additions have been demonstrated to be effective
in the C-C bond formation. The aldol reaction of chiral enolates, proceeds with decreasing yields and enantioselectivities
as the steric demand of the α-R of ephedrine amides and the size of carbonyl compound increase.
In addition, the use of branched groups on N,N-disubstituted norephedrine esters is highly recommended in the
aldol reactions of aromatic and aliphatic aldehydes.In the case of N-Acyl or O-Acyl ephedrines supported on
polymers, the reaction proceed with good enantioselectivities but low yields, the enantioselectivities are goods
but the yields are low. In general, the removal step of the auxiliary proceeds with low to high yields but without
epimerization.
Pendidikan akhlak mulia pada sekolah menengah pertama Bina Anak Soleh Tuban
Authors: Unwanullah Arif , Zuchdi Darmiyati 
Published: September 2017

Pendidikan akhlak mulia selama ini lebih menekankan pada aspek pengetahuan dari pada aspek sikap dan aplikasinya. Fenomena tawuran pelajar dan pergaulan bebas menjadi bukti. Sekolah Islam berasrama dengan kurikulum khasnya dianggap berhasil mengelola pendidikan karakter akhlak mulia. Namun belum semua sekolah mampu mengelolanya secara efektif. Penelitian ini bertujuan mengetahui dan menggali data mengenai bagaimana perencanaan, implementasi, evaluasi, dan pengelolaan asrama (boarding school system) pendidikan akhlak mulia dilakukan. Penelitian menggunakan pendekatan kualitatif, merupakan studi kasus SMP BAS school boarding sistem Tuban. Temuan penelitian menunjukkan bahwa sekolah melakukan perencanaan program diawali dengan penetapan visi dan misi, tujuan, standart kelulusan, menyusun kurikulum terpadu mengintegrasikan antara kurikulum nasional dan kurikulum khas pondok pesantren dengan penekanan pada pendidikan akhlak mulia. evaluasi dilakukan terus menerus terhadap seluruh aspek kegiatan siswa. Keberhasilan ditandai adanya perubahan perilaku siswa seperti disiplin, rajin ibadah, taat, jujur, dan berprestasi. Masyarakat makin percaya dan lembaga makin berkembang. Salah satu rekomendasi penelitian agar semua pemangku kepentingan komitmen terhadap rencana, menjadi contoh dan melakukan pembinaan terus menerus serta menjalin kemitraan.Kata kunci: pengelolaan, pendidikan, akhlak mulia GOOD MANNERS EDUCATION AT YUNIOR HIGH SCHOOL TUBANAbstractGood manner education tends to emphasize on knowledge but weak on attitude and its application. The phenomenon of students do juvenile delinquency, promiscuity, and abuse of drugs. Islamic boarding schools with integrating curriculum of national and local /manhaj tarbiyah emphasizes on Islamic religion subjects and good manner values to students. However, many schools have not succeded in managing good manner education yet. This study is aimed to know and find out data about planning, implementation, evaluation, and management school boarding of good manner eduction as a case study of qualitative research in SMP BAS school boarding system Tuban. The study finds that the planning program is formulated in school vision and mission, gol, standart graduation, develop integrated curriculum, and actualizes in active learning process, develop students’ extra activity, religious habit and leadership. Evaluation conducted on whole activities continuously. The success of managerial implementation has been indicated by students’ attitude changes such as disciplinary, obedience, learning achievement, and less violence. For making effective good manner education program should involve of parents community, togetherness and commitment.Keywords: managing, good manner, islamic based
Library Programs and Special Libraries
Authors: Fry Ray M. 
Published: September 2017

Although most of the programs administered in my Office primarily benefit public and academic libraries, several of our programs can significantly benefit special libraries and school libraries. I do realize also that many of the libraries represented in the Education Division are in academic libraries. Of course, in this day of electronic resource-sharing, strengthening any library of any type that is connected to a major network such as the Internet strengthens all libraries of any and every type that are also connected to the Internet.
SOME PORTRAYALS OF LIBRARIANS IN FICTION - A DISCUSSION
Authors: Brown-Syed Christopher , Sands Charles Barnard 
Published: September 2017

This article explores portrayals of librarians in selected works of fiction, notably those involving mystery or detection. It begins with a summary of information derived from descriptions of about one hundred and twenty contemporary or recent works, then discusses particular stories involving detection or mystery, with occasional references to other genres such as science fiction, historical fiction, espionage, and romance. In 1996, we began to compile a bibliography of fiction involving librarians to accompany a graduate course introducing the profession. Entries were obtained through searches of online catalogues and databases, as well as through queries posted over Internet LISTSERVs. About 120 individual works and about a dozen bibliographies were included in the resulting list. In many instances, librarians and their places of work were presented as intrinsically interesting and appealing. In more than half of the works, librarians played leading or major supporting roles. Following a categorization of the roles of librarians in these works, the article examines images of the profession in the works of Umberto Eco, L.R. Wright, and Charlotte McLeod. We contend that, even in works which present casual glimpses of the profession, or even in those which stress less desirable images of its members, accurate details of its techniques and working realities are sometimes discernible. We suggest that further research concentrate upon the work done by fictitious librarians and upon their centrality to plots.
THE PRISON LIBRARY: A VITAL LINK TO EDUCATION, REHABILITATION, AND RECREATION
Authors: Lehmann Vibeke 
Published: September 2017

This article has been adapted from a paper presented by the author in Cienfuegos, Cuba, November 1999 at the invitation ofUNEAC (Union Nacional de Escritores y Aristas Cubano) and the provincial public library in Cienfuegos. In cooperation with other prison programs the prison library plays a critical part in the education and rehabilitation of incarcerated persons. The background, roles, services, and ways in which the modern prison library can meet the needs of both inmates and prison staff are examined in depth. International and national standards exist as tools that cover all aspects of prison library operations. The most vital link in the operation of such libraries is having competent, well-trained, enthusiastic, and patient library staff equipped with the special human skills needed to deal with difficult prison patrons.
Information transforming society: challenges for the year 2000
Authors: Bearman Toni Carbo 
Published: September 2017

Improved access to information, through an expanded ability to find and use information effectively and the convergence of technologies, is transforming society. This presentation will describe several trends, including sociocultural and political, economic, and technological developments, and discuss the issues they raise for the global village. A description of challenges facing the information professions with recommendations for meeting them for the next decade will conclude the presentation. The trends will present a US perspective on national and international sociocultural and political changes, including demographic shifts to an older and more culturally diverse society in the US, a shift to visually-oriented from print-oriented information users, differing perceptions of the value of information, major international political developments, and a fundamental questioning of the notion of public good. Economic trends will highlight the effects of changing markets, fiscal constraints, and the shifting marketplace. Technological trends will focus on developments in networking and the convergence of technologies, especially those related to image databases. These trends provide the framework and background for a discussion to issues to be addressed and challenges to be met. The issues concern access to information and include policy and ethical concerns related to who should have access to what information, who should be responsible for information provision, who should pay for what information, and other topics. Particular attention must be paid to the widening gap between the information rich and the information poor. To address these issues will require meeting a number of challenges in the years ahead. The first challenge is to recruit and educate the information professionals needed to provide information products and services and access to them. Other challenges include building effective networks, developing and implementing standards, developing appropriate information policies, and, most importantly, addressing critical ethical issues. To meet these challenges will require strengthening existing and building new partnerships across organizational and institutional boundaries and across national borders.
The correlation between job satisfaction, job attitudes and work behaviour among the staff in academic libraries in Nigeria
Authors: Nkereuwem Edet E. 
Published: September 2017

Many scholars and entrepreneurs have expressed concern about the attitude of Nigerians to work. Sometimes it is difficult to associate the need of the Nigerian worker with motivational theories because it is argued that it appears as if the Nigerian worker is unresponsive to motivation. This study investigates what motivates a Nigerian worker in order to establish whether his/her preferences are different from those of his/her counterparts elsewhere. The framework adopted for this study is both descriptive and analytical. The population consists of 620 respondents in 15 Nigerian universities and polytechnics. A response rate of 477 representing 76.9% was recorded. The results indicate that workers in academic libraries in Nigeria respond positively to monetary rewards as incentive to improved job attitude and work performance. It was also found that other factors outside their work environment also affect the level of their job satisfaction.
Towards access to information in rural India
Authors: Raju K.A. 
Published: September 2017

Rural areas in India are characterized by limited land availability, low literacy, inadequate health, sanitary and drinking water facilities. In spite of over five decades of independence, the rural scenario has not changed much and 75% of rural people are either manual laborers, or artisans. In view of a variety of structural disadvantages, i.e., illiteracy, malnutrition, and the social complications of caste in Indian society, there is a need to redesign the traditional public library and its services to deal with the information needs of rural areas. In this connection, the National Institute of Rural Development (NIRD) conducted a variety of studies and has come up with an action research project aimed at establishing Public Information Centers (PIC's). The objective of these centers will be to provide information on rural development programmes, agricultural extension, and utilities as well as social development information, e.g., health, education, finance, legal. This paper discusses the issues involved as well as the location of PIC's, databases, training, service and the sustenance of PIC's.
Digital library activities in the Bibliotheksservice-Zentrum Baden-Wuerttemberg
Authors: Kühn Armin , Mainberger Christof 
Published: September 2017

The Bibliotheksservice-Zentrum Baden-Wuerttemberg (Library Service Centre Baden Wuerttemberg) participates in several programms to expand well-tried methods of library work to a “Digital Library”. Those endevours are driven by the demand to integrate traditional library services with multimedia and the World Wide Web. Central results of this work are the metadata modell DLmeta and the Virtual Media Server. DLmeta is an extension of the Dublin Core Metadata Element Set, which takes library aspects into account, supports workflow and realizes an object model that support document management. There are a XML representation of DLmeta for data-interchange and relational specifications. DLmeta is proposed to describe any kind of electronic media and is the basis for the Virtual Media Server. The Virtual Media Server is a central database for recording descriptions of multimedia objects, which reside on distributed object servers themselves. Besides the description, each record provides a link to the object and a link to a corresponding holding record in the union catalog of the Suedwestdeutscher Bibliotheksverbund. The retrieval is performed via the OPAC of the Union catalog or via specialized meta search engines. The Bibliotheksservice-Zentrum applies DLmeta and the Virtual Media Server to a wide range of multi-media objects. There are full text and university publications, audio- and video-files, digitized scores and teaching and learning material. Current projects deal, e.g., with the administration of unsystematically digitized stock, interdisciplinary cooperation of libraries, archives and museums, and multimedia objects, which are subject to continuous change.
Interactive Science Publishing: A joint OSA–NLM project
Authors: Ackerman Michael J. , Siegel Elliot , Wood Fred 
Published: September 2017

Interactive Scientific Publishing (ISP) has been developed by the Optical Society of America with support from the National Library of Medicine at NIH. It allows authors to publish papers which are linked to the referenced 2D and 3D original image datasets that can then be viewed and analyzed interactively by the reader. ISP provides the software for authors to organize and publish source data while offering readers the viewing and analysis tools. The ultimate goal of ISP is to improve learning and understanding of the information being presented. The results reported here are intermediate in reaching the ultimate goals. Goals: Implement and evaluate online user access to interactive datasets that complement online scientific papers. Methods: Software development; website evaluation, including web log data monitoring, online user survey. Results: An expert group of respondents found the interactive data component to have positive impacts on understanding and discovery. However a significant minority reported that the software interface, instructions, and/or download presented a barrier to effective use of the interactive data functionality. Conclusions: This exploratory study indicates that interactive datasets offer potential benefits as a complement to published papers, but that further software improvements and more in-depth evaluation are needed to best discern future directions.
Futures thinking for academic librarians: Higher education in 2025
Authors: Staley David J. , Malenfant Kara J. 
Published: September 2017

For academic librarians seeking to demonstrate the value of their libraries to their parent institutions, it is important to understand not only the current climate. We must also know what will be valued in the future so that we can begin to take appropriate action now. This document presents 26 possible scenarios based on an implications assessment of current trends, which may have an impact on all types of academic and research libraries over the next 15 years. The scenarios represent themes relating to academic culture, demographics, distance education, funding, globalization, infrastructure/facilities, libraries, political climate, publishing industry, societal values, students/learning and technology. They are organized in a “scenario space” visualization tool, reflecting the expert judgment of ACRL members as to their expectations and perceptions about the probability, impact, speed of change and threat/opportunity potential of each scenario. Finally, the study draws out implications for academic libraries. For scenarios which have been identified as high impact with a high probability of occurring, it is incumbent upon library directors and those who set strategic agendas for academic libraries to plan to act now upon these scenarios. This report reinforces the notion that academic libraries are part of a larger ecosystem, and librarians should be consistently scanning the environment to look for signs of the changes that may come. It includes an appendix with a suggested activity to engage library colleagues in stretching your imaginations and considering possible futures. This can build capacity to engage in strategic thinking and planning, supporting librarians in making better decisions now that can address a variety of possible futures.