bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of social determinants of health on quality of life in patients with multimorbidity and polypharmacy
Authors: Ruiz-Baena José María , Moreno-Juste Aida , Poblador-Plou Beatriz , Castillo-Jimena Marcos , Calderón-Larrañaga Amaia , Lozano-Hernández Cristina , Gimeno-Miguel Antonio , Gimeno-Feliú Luis A. ,   MULTIPAP GROUP
Published: September 2024

Background
Multimorbidity is one of the biggest challenges faced by modern medicine, especially when managing older patients who are also often taking multiple medications. Multimorbidity is influenced by social determinants of health, giving rise to health inequalities in the population. Here, we sought to determine the influence of social determinants of health on quality of life in patients with multimorbidity and polypharmacy.

Methods and materials
This cross-sectional observational study included 573 patients aged 65–74 with multimorbidity (≥3 diseases) and polypharmacy (≥5 drugs). Corresponding data was taken drawn from the Spanish MULTIPAP study, and included social and demographic variables, and data on health-related quality of life and overall self-perceived health status, assessed using the 5-level version of the EuroQol 5-dimensional questionnaire (EQ-5D-5L). Descriptive, bivariate and multivariate analyses with logistic regression models were performed.

Results
Mean patient age was 69.7 years, 55.8% of patients were female, 59.7% belonged to low social classes (V, VI), a monthly income of €1051–€1850 predominated, and the median number of diseases in the same patient was 6. Factors associated with higher quality of life were (odds ratio, OR) male gender (OR = 1.599, p = 0.013), a higher educational level (OR = 1.991, p = 0.036), an absence of urban vulnerability (OR = 1.605, p = 0.017), and the presence of medium social support (OR = 1.689, p = 0.017). Having a higher number of diseases was associated with poorer quality of life (OR = 0.912, p = 0.017).

Conclusions
Our findings describe associations between social determinants of health and quality of life in patients aged 65–74 years with multimorbidity and polypharmacy. More illnesses, female gender, a lower education level, urban vulnerability, and less social support are associated with poorer quality of life, underscoring the need for a biopsychosocial approach in patient care.
Exploring barriers and facilitators, and their effectiveness in eye health promotion interventions: Protocol of a systematic review
Authors: Masemola Hlabje Carel , Nkambule Sphamandla Josias , Baloyi Olivia , Xulu-Kasaba Zamadonda Nokuthula 
Published: September 2024

Background
The rising global prevalence of visual impairment attributed to population growth and ageing heightens the risk of increased vision problems for many. However, there is a limited understanding of factors influencing intervention implementation, and the degree to which participation is achieved in interventions for eye health promotion by eye care professionals is currently limited.

Aim
The purpose of this protocol is to review evidence on barriers and facilitators in eye health promotion, and their effectiveness on interventions employed in eye health promotion.

Methods and expected outputs
The Center for Reviews and Dissemination (CRD) guidance for conducting systematic reviews in healthcare and reporting in accordance with the PRISMA statement will serve as the basis for the implementation of the proposed systematic review. Systematic literature searches will be performed by searching three databases, as well as hand-searching articles eligible for inclusion. The searches will include peer-reviewed articles presenting evidence on eye health promotion intervention from the inception of the Vision 2020 Campaign to the present day. RevMan 5.3 software will be used to gather quantitative data, such as (Effectiveness), meta-analysis of such data will be performed. Two reviewers will conduct a quality appraisal of the included articles using the mixed methods appraisal tool (MMAT) 2018 version. We expect to find relevant studies on health promotion interventions among health professionals at different levels of care. The synthesized evidence will help guide further implementation of research on health promotion interventions for eye health.
The pathway of social support in enhancing adolescents’ physical fitness: The mediating roles of physical activity and self-efficacy
Authors: Xu Zhiyong , Xu Jinwen , Liu Tianshu , Gu Zhiyang , Hu Donglin 
Published: September 2024

Purpose
Utilising Welk’s Youth Physical Activity Promotion (YPAP) model as a foundational framework, this study investigates the intricate interplay of social support, physical activity (PA), and self-efficacy in relation to physical fitness within the context of Chinese culture. The primary objective is to identify the nuanced dynamics among social support, self-efficacy, PA, and physical fitness to enhance adolescent well-being and fitness.

Methodology
The study employed a convenience sampling method, engaging 123 adolescents aged 18–21, of which 67 were females (54.47%), and 56 were males (45.53%). Data were collected through structured questionnaires focusing on the identified variables.

Results
Our study revealed significant positive associations among social support, self-efficacy, PA, and physical fitness, with correlation coefficients ranging from 0.282 to 0.419. Notably, a discernible gender disparity emerged, with females exhibiting higher levels of physical fitness. Among the key determinants of adolescent physical fitness, self-efficacy emerged as the most influential, followed by PA and gender. Utilising structural equation modelling and regression techniques, we discerned that social support indirectly influences physical fitness, primarily mediated by self-efficacy and the level of physical activity.

Discussion
This study provides insight into how social support impacts adolescent physical fitness. We found that social support strongly predicts both PA and self-efficacy, and self-efficacy significantly boosts PA, ultimately leading to improved physical fitness. Both self-efficacy and PA serve as mediators in the relationship between social support and fitness. Therefore, interventions should prioritise reinforcing social support, promoting PA, and nurturing self-efficacy to optimise adolescent physical fitness outcomes.
A window into the mind-brain-body interplay: Development of diagnostic, prognostic biomarkers, and rehabilitation strategies in functional motor disorders
Authors: Gandolfi Marialuisa , Sandri Angela , Mariotto Sara , Tamburin Stefano , Paolicelli Anna , Fiorio Mirta , Pedrotti Giulia , Barone Paolo , Pellecchia Maria Teresa , Erro Roberto , Cuoco Sofia , Carotenuto Immacolata , Vinciguerra Claudia , Botto Annibale , Zenere Lucia , Canu Elisa , Sibilla Elisa , Filippi Massimo , Sarasso Elisabetta , Agosta Federica , Tinazzi Michele ,   on behalf of the Group Collaborators Consortium
Published: September 2024

Background and aims
Functional motor disorders (FMD) present a prevalent, yet misunderstood spectrum of neurological conditions characterized by abnormal movements (i.e., functional limb weakness, tremor, dystonia, gait impairments), leading to substantial disability and diminished quality of life. Despite their high prevalence, FMD often face delayed diagnosis and inadequate treatment, resulting in significant social and economic burdens. The old concept of psychological factors as the primary cause (conversion disorder) has been abandoned due to the need for more evidence about their causal role. According to a predictive coding account, the emerging idea is that symptoms and disability may depend on dysfunctions of a specific neural system integrating interoception, exteroception, and motor control. Consequently, symptoms are construed as perceptions of the body’s state. Besides the main pathophysiological features (abnormal attentional focus, beliefs/expectations, and sense of agency), the lived experience of symptoms and their resulting disability may depend on an altered integration at the neural level of interoception, exteroception, and motor control.

Methods and materials
Our proposal aims to elucidate the pathophysiological mechanisms of FMD through a three-stage research approach. Initially, a large cohort study will collect behavioral, neurophysiological, and MRI biomarkers from patients with FMD and healthy controls, employing eXplainable Artificial Intelligence (XAI) to develop a diagnostic algorithm. Subsequently, validation will occur using patients with organic motor disorders. Finally, the algorithm’s prognostic value will be explored post-rehabilitation in one subgroup of patients with FMD.

Results
Data collection for the present study started in May 2023, and by May 2025, data collection will conclude.

Discussion
Our approach seeks to enhance early diagnosis and prognostication, improve FMD management, and reduce associated disability and socio-economic costs by identifying disease-specific biomarkers.

Trial registration
This trial was registered in clinicaltrials.gov (NCT06328790).
Study protocol of the ASTOP trial: A multicenter, randomized, double-blind, placebo-controlled trial of presurgical aspirin administration for the prevention of thromboembolic complications of coil embolization for ruptured aneurysms
Authors: Hirai Sakyo , Fujita Kyohei , Fujii Shoko , Takahashi Satoru , Shigeta Keigo , Karakama Jun , Enomoto Yukiko , Sato Yohei , Yoshimura Masataka , Hirota Shin , Mizoue Tatsuya , Yoshino Yoshikazu , Kawano Yoshihisa , Yamamura Toshihiro , Kohyama Shinya , Hirohata Masaru , Yoshimura Shinichi , Ishii Yosuke , Yamauchi Toshihiro , Taira Naoki , Obata Yoshiki , Sakamoto Makoto , Inoue Masato , Yamashina Motoshige , Tokunaga So , Higashi Toshio , Sawada Kana , Mochida Hidetoshi , Ido Keisuke , Takeuchi Masataka , Takigawa Tomoji , Takagi Yasushi , Morimoto Masafumi , Nanto Masataka , Miki Kazunori , Misaki Kouichi , Arimura Koichi , Hanaoka Yoshiki , Hara Mutsuya , Hara Shoko , Yokoyama Kota , Ooyama Jun , Hanazawa Ryoichi , Sato Hiroyuki , Hirakawa Akihiro , Ishiguro Megumi , Nemoto Shigeru , Sumita Kazutaka 
Published: September 2024

Rationale
Thromboembolism is a serious complication of endovascular treatment for ruptured cerebral aneurysms. The administration of antiplatelet agents before endovascular treatment for ruptured cerebral aneurysms may reduce the risk of thromboembolic complications.

Aim
This study aimed to assess the safety and efficacy of preoperative aspirin administration in endovascular treatment for ruptured cerebral aneurysms.

Sample size estimates
Assuming a 15% incidence rate of both intraoperative thromboembolic morbidity and symptomatic ischemic lesions on magnetic resonance imaging diffusion-weighted imaging scans assessed by an Independent Review Committee, a sample size of 484 will be required to detect a 10% improvement with aspirin administration with 90% power using the Pearson’s chi-square test at a two-sided significance level of 2.5% for each primary outcome, after accounting for a 5% dropout rate.

Methods and design
ASTOP is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 484 patients with ruptured cerebral aneurysms receiving coil embolization within 72 h of onset will be randomly assigned 1:1 to receive 200 mg of aspirin or placebo before the procedure.

Study outcomes
The primary outcomes will be the incidence rates of intraoperative thromboembolic complications and symptomatic ischemic lesions on magnetic resonance imaging diffusion-weighted imaging scans evaluated by the Independent Review Committee. The secondary outcomes will be the incidence rate of cerebral ischemic events and all bleeding events within 14 days of enrollment and functional outcomes defined by the modified Rankin Scale score at 90 days.

Discussion
This trial will provide valuable data on the role of antiplatelet agents during endovascular treatment for ruptured cerebral aneurysms.

Trial registration
Registration: Japan Registry of Clinical Trials, Identifier: jRCTs031210421.
Pityriasis lichenoides acuta after COVID-19 vaccination
Authors: Singh Maneesh 
Published: September 2024

This case is notable due to the possible association between pityriasis lichenoides et varioliformis acuta (PLEVA) and the COVID-19 vaccination. In this case report we discuss a case of a 32 year-old male who developed erythematous, oval-shaped papules on his trunk, upper and lower extremities 2 weeks after his Covid 19 vaccination.
We also discussing the the diagnostic and therapeutic challenge of this disease and how a misdiagnosis of this disease can lead to great amount of emotional and psychological stress for the patient and his family members. For this reason it is important to have this on the list of possible diagnosises.
Die wissenschaftlichen Bibliotheken der DDR nach der Wiedervereinigung
Authors: Knoche Michael 
Published: September 2024

Zusammenfassung
Die Transformation der wissenschaftlichen Bibliotheken der DDR nach der Wiedervereinigung führte zu einer Modernisierung von Strukturen, Bestand und Technolgie sowie zu einer personellen Erneuerung. Das Zusammenwirken von ost- und westdeutschen Bibliothekaren hat sich von der ersten Stunde an als äußerst produktiv erwiesen. Vom Transformationsprozess hat das gesamte deutsche Bibliothekssystem profitiert, insbesondere die Verbünde. Standardisierung und Anwendung von Normdaten wurden beschleunigt, überregionale Projekte gewannen an Substanz.
Solvability of infinite system of integral equations of Hammerstein type in three variables in tempering sequence spaces
c
0
β
{c}_{0}^{\beta }
and
ℓ
1
β
{\ell }_{1}^{\beta }
Authors: Simbeye Mesia , Kumar Santosh , Mursaleen M. 
Published: September 2024

Abstract
The objective of this study is to determine the criteria under which the infinite system of integral equations in three variables has a solution in the Banach tempering sequence space

c

0

β

{c}_{0}^{\beta }

and

ℓ

1

β

{\ell }_{1}^{\beta }

, utilizing the Meir-Keeler condensing operators. Our research builds upon the findings of Malik and Jalal. Furthermore, we provide illustrative examples to demonstrate the implications of our established conditions.
Assessment of sugarberry as a host tree of Halyomorpha halys (Hemiptera: Pentatomidae) in southeastern USA agroecosystems
Authors: Tillman Patricia Glynn , Cottrell Ted E. , Kesheimer Katelyn A. , Grabarczyk Erin E. 
Published: September 2024

Abstract
The brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is an invasive, polyphagous pest known to disperse between non-crop host plants and crops searching for food. Sugarberry (Celtis laevigata Willdenow; Cannabaceae) is commonly found in woodland habitats in the southeastern USA and may serve as a non-crop host for H. halys. Therefore, the main objective of this two-year study was to determine if 1) sugarberry serves as a host tree and 2) whether natural enemies attack H. halys sentinel egg masses in the tree canopy. We monitored H. halys in sugarberry trees in woodlands bordering field crops in Prattville, Alabama during 2022 and similarly for orchard crops in Byron, Georgia during 2023. Each year pheromone-baited stink bug traps were deployed in the canopy of trees to capture H. halys. We evaluated parasitism and predation of H. halys by placing sentinel egg masses in tree canopies. H. halys males and females and 2nd through 5th instars were captured in tree traps over the season for each location. Trissolcus euschisti (Ashmead) (Hymenoptera: Scelionidae) was the only parasitoid species that emerged from H. halys eggs. Chewing and stylet sucking were the primary types of predation on sentinel egg masses. We conclude that sugarberry is a reproductive host for H. halys, and native natural enemies provide biological control services of H. halys eggs on this host.
Promoting the sustainable construction: A scientometric review on the utilization of waste glass in concrete
Authors: Qayyum Arshad , Javed Muhammad Faisal , Asghar Raheel , Iqtidar Ammar , Alabduljabbar Hisham , Khan Mohsin Ali , Ali Mujahid 
Published: September 2024

AbstractConcrete is the second-most used material globally and significantly impacts the environment by emitting a large amount of carbon dioxide (CO2). This scientometric review investigates the sustainable use of waste glass (WG) in concrete. Our study examines the impact of waste glass powder (WGP) on the mechanical and fresh characteristics of concrete and its environmental implications, enhanced by a machine learning prediction model. We observed a progressive increase in research activity on WGP-based concrete since 2000, indicating the growing interest in this area. The primary focus areas are engineering and material science, reflecting the application potential, structural performance, and material properties of WGP-based concrete. Our discussions highlight the significant benefits of WGP in concrete, including its potential to reduce landfill usage, environmental pollution, and enhance properties such as strength, sulfate resistance, alkali–silica reaction resistance, and freeze–thaw resistance. The review also explores the microstructure of glass powder (GP)-based concrete, illuminating the complex interactions between glass particles and the concrete matrix, which influence the material’s overall performance. Environmental impact assessments underscore the necessity for sustainable construction practices and waste reduction. Utilizing machine learning prediction models helps optimize the composition of GP-based concrete, thus enhancing material performance and durability. This review provides a comprehensive analysis of using WG in concrete, contributing to the field’s understanding and informing future research and innovations to optimize WG use in concrete applications.
Involvement of kinases in memory consolidation of inhibitory avoidance training
Authors: Montiel Ivan , Bello-Medina Paola C. , Prado-Alcalá Roberto A. , Quirarte Gina L. , Verdín-Ruvalcaba Luis A. , Marín-Juárez Tzitzi A. , Medina Andrea C. 
Published: September 2024

Abstract
The inhibitory avoidance (IA) task is a paradigm widely used to investigate the molecular and cellular mechanisms involved in the formation of long-term memory of aversive experiences. In this review, we discuss studies on different brain structures in rats associated with memory consolidation, such as the hippocampus, striatum, and amygdala, as well as some cortical areas, including the insular, cingulate, entorhinal, parietal and prefrontal cortex. These studies have shown that IA training triggers the release of neurotransmitters, hormones, growth factors, etc., that activate intracellular signaling pathways related to protein kinases, which induce intracellular non-genomic changes or transcriptional mechanisms in the nucleus, leading to the synthesis of proteins. We have summarized the temporal dynamics and crosstalk among protein kinase A, protein kinase C, mitogen activated protein kinase, extracellular-signal-regulated kinase, and Ca2+/calmodulin-dependent protein kinase II described in the hippocampus. Protein kinase activity has been associated with structural changes and synaptic strengthening, resulting in memory storage. However, little is known about the molecular mechanisms involved in intense IA training, which protects memory from typical amnestic treatments, such as protein synthesis inhibitors, and induces increased spinogenesis, suggesting an unexplored mechanism independent of the genomic pathway. This highly emotional experience causes an extinction-resistant memory, as has been observed in some pathological states such as post-traumatic stress disorder. We propose that the changes in spinogenesis observed after intense IA training could be generated by protein kinases via non-genomic pathways.
Green synthesized AgNPs of the Anchusa arvensis aqueous extract resulting in impressive protein kinase, antioxidant, antibacterial, and antifungal activities
Authors: Mohany Mohamed , Ali Jamshed , Wahab Abdul , Fozia Fozia , Shah Syed Majid , Gul Rukhsana , Gul Ahmad , Ahmad Ijaz , Milošević Marija , Al-Rejaie Salim S. , Aboul-Soud Mourad A. M. 
Published: September 2024

Abstract
This study focused on analyzing the pharmacological activities of AgNPs synthesized from an aqueous plant extract of Anchusa arvensis. The effectiveness of AgNPs was evaluated for protein kinase inhibition, antioxidant, antibacterial, and antifungal activities. The AgNPs and plant were used to regulate the protein kinase activity using the liquid TSB and ISP4 medium protein kinase inhibition study demonstrated that nanoparticles exhibited a larger zone of inhibition (9.1 ± 0.8) compared to the plant extract (8.1 ± 0.6). The antioxidant activity was assessed using DPPH reagent, and the results indicated that AgNPs displayed potent free radical scavenging properties. In terms of antibacterial activity, AgNPs showed higher efficacy against Enterobacter aerogens (20.1 ± 0.9), Bordetella bronchiseptaca (19.1 ± 0.9), and Salmonella typhimurium (17.2 ± 0.8) at 4 mg/mL. The antifungal activity of AgNPs was prominent against Aspergillus fumagatus (14.1 ± 0.9), Mucor species (19.2 ± 0.8), and Fusarium solani (11.2 ± 0.8) at 20 mg/mL. These findings suggest that AgNPs possess multiple beneficial properties, including bactericidal/fungicidal effects, protein kinase inhibition, and potential free radical scavenging abilities. Therefore, AgNPs have potential applications in various fields, such as biomedicine and industry, due to their ability to counteract the harmful effects of free radicals.
Electrocardiographic Evaluation the Effect of Thiamine Hydrochloride on Triton X-100 Induced Hyperlipidemia in Rats
Authors: Ozdemir Murat Taha , Ekici Mehmet 
Published: September 2024

Aim:	Hyperlipidemia,	a	prevalent	condition	globally,	contributes	significantly to	cardiovascular	diseases.	This	research	focuses	on	the	impacts	of	thiamine hydrochloride	on	lipid	profiles	and	ECG	changes	in	rats	with	Triton	X-100 induced	hyperlipidemia. Materials and Methods:	A	total	of	eighteen	male	Wistar	Albino	rats were	divided	into	three	groups:	control,	Triton	X-100,	and	Triton	X-100	+ Thiamine.	To	induce	hyperlipidemia,	Triton	X-100	was	administered	as	a single	intraperitoneal	dose	of	100	mg/kg.	Thiamine	hydrochloride	was	then given	intraperitoneally	at	a	dose	of	25	mg/kg	daily	for	7	days,	starting	72 hours	after	the	induction	of	hyperlipidemia.	ECG	data	were	recorded,	and serum	biochemical	parameters	were	analyzed. Results:	Thiamine	treatment	significantly	reduced	elevated	total	cholesterol and	triglyceride	levels	induced	by	Triton	X-100.	It	also	improved	the	coronary risk	index	and	normalized	ECG	characteristics	include	the	heart	rate	and	the RR	interval.	ECG	abnormalities,	including	ST	segment	elevation	and	atrial fibrillation,	were	less	frequent	in	the	thiamine-treated	group. Conclusion:	Thiamine	hydrochloride	effectively	mitigates	hyperlipidemia	and its	associated	cardiovascular	risks,	suggesting	its	potential	as	a	therapeutic agent.	Further	research	is	needed	to	explore	its	clinical	applications	in managing	dyslipidemia	and	cardiovascular	diseases.