bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between IgM deposition intensity in renal tissue and 5-year renal prognosis in immunoglobulin A nephropathy
Authors: Gao Li , Zhang Xuan , Yu Dongrong , Jiang Mengjie , Yu Can , Li Xiaohong , Zhu Qin 
Published: September 2024

Abstract

[Objective] This study aimed to examine both the clinical and renal tissue humoral immunodeposition profiles in immunoglobulin A nephropathy (IgAN) and identify factors influencing its prognosis. [Methods] A retrospective analysis was conducted on clinicopathological data from 774 patients with primary IgAN, confirmed via renal biopsy, at Hangzhou Hospital of Traditional Chinese Medicine between January 1, 2016, and December 31, 2018. Patients were categorized into end-event and non-end-event groups based on whether they reached the renal composite endpoint, defined as a ≥ 50% decline in eGFR or progression to end-stage renal disease (ESRD). Risk factors for adverse renal outcomes were evaluated using univariate and multivariate Cox regression models. Patients were further divided into three groups based on IgM deposition levels in the glomerular mesangial area: IgM-negative, low (IF ≤ 2+), and high (IF > 2+). Comparative analyses of clinical and histopathological characteristics, along with treatment regimens, were performed across these groups. [Results] The high IgM deposition group exhibited significantly lower serum albumin and eGFR levels, alongside higher cholesterol, 24-hour urine protein, and blood immunoglobulin M levels compared to the IgM-negative and low deposition groups. Multivariate Cox regression analysis identified immunosuppressant use as an independent protective factor for IgAN prognosis, while low serum albumin, T2 lesions, and nephropathological IgM deposits were recognized as independent risk factors for the 5-year prognosis of IgAN. Kaplan-Meier survival curves revealed that patients with high IgM deposition had markedly poorer prognoses compared to those with negative or low deposition. [Conclusion] Besides low serum albumin and T2 lesions, IgM deposition in the mesangial region emerged as an independent risk factor for the 5-year prognosis of IgAN.
Study on apoptosis of human melanoma cell Induced by solanine in vitro and its mechanism
Authors: Feng Sen , Ren Mingyuan , Chen Sijia , Wang Bin , Zhang Yajun , Zhang Guoqiang 
Published: September 2024

Abstract

Objects:
Melanoma (malignant melanoma, MM) is a highly aggressive tumor, ranking as the third most common cutaneous malignancy, characterized by high metastatic potential, mortality, and poor prognosis. Solanine is a major steroidal alkaloid found in potatoes, and its anticancer benefits have been widely reported. However, its inhibitory effects on melanoma cells have been less studied. The aim of this study was to observe the effects of solanine on the proliferation, apoptosis and related apoptotic proteins of melanoma A375 and A2058 cells, and then to investigate the possible anti-tumor mechanism of solanine.
Methods
The morphological changes of apoptosis induced by varying concentrations of solanine in melanoma A375 and A2058 cells were observed using an inverted microscope. The proliferation inhibition rate of melanoma cells was examined using CCK-8 proliferation assay. DAPI staining was employed to observe cell growth and morphological alterations. Gene and protein expression levels of apoptosis-related genes (Caspase-3, Bcl-2 and Bax) were detected by quantitative real-time polymerase chain reaction (RT-qPCR) and western blot analysis.
Results
Within a certain concentration and time range, solanine can inhibit the viability of A375 and A2058 cells significantly in a time-dose-dependent manner (P < 0.05). Apoptosis induced by solanine was confirmed through DAPI staining. Notably, there was a marked decrease in the anti-apoptotic protein Bcl-2, alongside a significant increase in the expression of Bax and Caspase-3 at both the mRNA and protein levels (P < 0.05).
Conclusion
Our data demonstrated the inhibiting proliferation and inducing apoptosis of solanine in melanoma A375 and A2058 cells, and revealed it may be associated with the mitochondrial apoptotic pathway.
Integrated Technique of Natural and Artificial Texts Authorship Verification in the Academic Environment
Authors: Romanov Aleksandr , Shelupanov Alexander , Kurtukova Anna , Fedotova Anastasiia 
Published: September 2024

Abstract

The issue of text plagiarism in academic and educational environments is becoming increasingly relevant every year. The quality of research articles and works is declining due to students copying fragments of others' works and using modern generative models for text and source code creation. The article proposes an integrated technique for authorship verification of both natural and artificial language texts, based on a combination of statistical methods, machine learning, and deep neural networks. The presented technique addresses several related tasks: assessing text homogeneity, detecting plagiarism when solving closed-set authorship attribution problems, and identifying texts and fragments created by generative models. Experimental data include a multi-domain dataset of natural language texts consisting of research articles on natural and technical sciences, PhD dissertations, and artificially generated texts on related topics. To evaluate the effectiveness of the technique in relation to artificial language texts, a multilingual program dataset was used, consisting of source codes for programs of technical students as well as artificially generated program codes. The experimental results demonstrate the effectiveness of the proposed technique for plagiarism detection and copyright protection in the educational process. The accu-racy of identifying heterogeneous fragments in text or code is 93–94%, authorship attribution ac-curacy is 89–99% depending on the number of co-authors, and verification accuracy is 97.5–99.4%.
The solvent effect in regulating the antioxidant activities of Curcumin and its metal complexes- An insight into the mechanism of action using DDPH assay
Authors: Breitener Priya , P.V Mohanan , Nair Balachandran. , Jawahar Lalitha , AlNeyadi Shaikha S. 
Published: September 2024

Abstract

IC50 values from DPPH assay using different polarity solvents are used to confirm the antioxidant mechanisms of curcumin and its complexes with metals. The antioxidant activity varies with the solvent. The protic solvent exhibits the maximum activity with the lowest IC50 value. The polar aprotic medium displays a comparably low activity with a larger IC50 value. The least activity been exhibited by nonpolar solvent with the highest IC50 value. Curcumin's IC50 value varies with solvent, indicating that it follows a distinct molecular route. The antioxidant activity showed a regular increasing trend with non-polar, polar aprotic and protic solvents. The trend suggests an unrelated mechanistic pathway SPLET (sequential proton loss electron transfer), SET-PT (sequential electron transfer-proton-transfer) and HAT (hydrogen atom transfer) operating in solvent used for the study. Curcumin metal complexes antioxidant activity are compared to curcumins to study the influence of groups such as o-methoxy, phenolic, and di-keto in determining their activity. The antioxidant activity of Curcumin-1 and its metal complex with enol center blocked by complexation were comparable suggestive of negligible involvement of enol center in deciding the efficiency and emphasizing on importance of phenol center. The activity of Curcumin-1 was maximum in all the solvents used, followed by the II and III fractions. The trend observed agree with the number of the o-methoxy group present in the substituent.
Advanced Ac-dc Power Flow Analysis: Evaluating the Impact of Control Parameters on System Performance
Authors: Yadaraju Vijay Prashant , M Siva Kumar 
Published: September 2024

Abstract

The paper addresses the challenges posed by the increasing integration of Direct Current (DC) transmission lines and system controllers into power systems. It presents a novel AC-DC load flow methodology designed to resolve the limitations of traditional AC-only models. This new approach integrates established AC load flow techniques with the specific requirements of DC systems, aiming to improve the analysis of mixed AC-DC networks. The proposed methodology, utilizing the Newton-Raphson algorithm, systematically evaluates performance by comparing it with conventional AC-only models and other hybrid methods through detailed test cases. The results show that the AC-DC load flow method significantly enhances both the accuracy and computational efficiency of power flow calculations. By effectively addressing the complexities of integrating AC and DC components, this method offers a robust and innovative solution for modern power system analysis, representing a notable advancement in the field.
Renal pseudohypoaldosteronism type 1 – an adult case series including a novel gene variant
Authors: Calissendorff Jan , Falhammar Henrik 
Published: September 2024

Abstract

Purpose
Renal pseudohypoaldosteronism type 1 (PHA1) is a rare disease affecting infants. Symptoms are failure to thrive, vomiting and weight loss. It is caused by gene variants in NR3C2 by which the mineralocorticoid receptor is dysfunctional, and patients develop hyponatremia, elevated plasma aldosterone and renin but have normal blood pressure. Little is known about PHA1in adults. We present four adults with PHA1, their clinical, biochemistry and genetic data.
Methods
Clinical and biochemical data were collected from the medical files and clinical examination of the participants. Genetic testing was performed.
Results
Two adult dizygotic twins and their mother, as well as an adult man were included. One of the sisters and the man had had severe hyponatremia and been admitted several times as young infants, treated with sodium chloride and fludrocortisone. All had as adults elevated plasma aldosterone and normal potassium. The females now had normal plasma renin, but it was increased in the male. A novel genetic variant in NR3C2 were found in the twins and their mother (c.1816T > C, p.(Cys606Arg)). All had normal blood pressure and were asymptomatic.
Conclusion
In adulthood PHA1 seems to be asymptomatic and long-term consequences favorable.
Geographical accessibility and inequalities in access to childbirth care in the Grand Conakry metropolitan area, Guinea: a spatial modelling study
Authors: GROVOGUI Fassou Mathias , Dioubate Nafissatou , Manet Hawa , Kpogomou Pepe , Millimouno Tamba Mina , Semaan Aline , Beňová Lenka , Delamou Alexandre , Macharia Peter 
Published: September 2024

Abstract

We modelled geographic accessibility, coverage, and wealth-based inequalities for childbirth care in Grand Conakry, Guinea. We assembled boundaries, health facilities, wealth index, road network, elevation, landcover, and geo-traced travel speeds. Using least-cost path algorithm, we computed travel times to the nearest facility by level and sector. We quantified the coverage (% of women of childbearing age) within 15, 30, and 60-minutes of the nearest facility and its variation by wealth index. Average travel speeds ranged from 14 to 28 km/h. Travel to any facility took 8-minutes, increasing to 22 for public hospitals (range from 5 to 33-minutes across communes). Coverage was 100% within 30-minutes of any facility, dropping to 82% for public hospitals, varying across communes. Slower speeds due to traffic substantially increased travel time and reduced coverage. Pro-rich inequalities emerged, especially in peri-urban communes with longer travel times. Targeted interventions are needed to reach equitable access to childbirth care.
Synthesis of Novel Graphene Oxide-Chitosan-Silicon Dioxide Embedded Polysulfone Membrane for Oily Water Treatment
Authors: Yasir Ahmed T. , Alshaibi Nadeen , Ndame Nchwa , Youssef Hind Ben , Ba-Abbad Muneer M. , Benamor Abdelbaki 
Published: September 2024

Abstract

Large quantities of produced water are generated during oil and gas exploration activities as for each barrel of oil, three barrels of produced water is generated. Due to their hydrophobic nature, conventional hydrophobic polymeric membranes struggle to effectively separate oil from produced water. In this work an innovative strategy is suggested by employing a hydrophilic/super-oleophobic nanocomposite to develop novel polymeric membranes able to effectively separate oil content from produced water without negatively affecting the other membrane properties such as the total flux and fouling. Graphene oxide-Chitosan-silicone oxide (GO-CH-SiO2) nanocomposite was synthesized by functionalizing graphene oxide (GO) with chitosan (CH) and silicon dioxide (SiO2). To improve the membrane flux, anti-fouling propensity and oil rejection, the synthesized nanocomposites were doped in the polysulfone membranes matrix. The effect GO-CH-SiO2 concentration, GO:CH ratio and GO-CH:SiO2 ratio on the performances of developed membranes were experimentally assessed and morphology of the synthesized membrane were investigated using appropriate characterization techniques. The experimental results showed that the membrane with GO:CH of 1:2 and GO-CH: SiO2 ratio of 1:6.5 showed the highest pure water permeation flux of 28.35 LMH/bar with a comparable flux recovery rate of 76% and oil rejection efficiency of 98.5%.
Effect of Wheat Bread Incorporated with Chamomile and Wild Thyme on Glycemic and Insulin Responses, Antioxidant Status and Inflammation in Type 2 Diabetic Individuals
Authors: Khan Imran , Ahmad Imtiaz , Johnson Stuart , Ahmad Jamil , Almajwal Ali Madi 
Published: September 2024

Abstract

Previous studies suggest that bread incorporated with chamomile and wild thyme powder exhibit lower starch digestibility and higher antioxidant activity in vitro and hence its intake may suppress postprandial blood glucose and enhance antioxidant status in humans. The present study determined the effect of bread incorporating chamomile and wild thyme on blood glucose, insulin, antioxidant status and inflammation in type 2 diabetic individuals. Sixteen male subjects consumed either control bread (CB) or bread incorporated with 3 % chamomile and wild thyme powder in two separate sessions. Blood glucose was measured by finger-prick method at fasting and then postprandially for 2 h. Plasma insulin, antioxidant and inflammatory markers were measured at fasting and 2 h after consumption. A non-significant decrease in blood glucose while a non-significant increase in insulin was observed after the consumption of chamomile and wild thyme-containing bread (CWB) compared to CB. Compared to baseline, the consumption of CWB increased total polyphenols, total antioxidant capacity (TOAC) and superoxide dismutase (SOD) activity by 6%, 20% and 15%, respectively. Similarly, CWB non-significantly decreased thiobarbituric acid reactive substances (TBARS) by 27% and C-reactive protein (CRP) by 12% compared to CB. In conclusion, the consumption of bread incorporated with chamomile and wild thyme resulted in an improvement in blood glucose and plasma insulin levels, a beneficial increase in polyphenols, TOAC, SOD activity and a reduction in TBARS and CRP levels in type 2 diabetic individuals. Further studies are now warranted with large sample sizes and larger doses to achieve significant clinical results.
Paschen-Back Effect-Driven Coordination Modulation of SO₄²⁻ Hydration for Dendrite-Free Zn Ion Batteries via Magnetized Electrolyte
Authors: Wang Zhi , Yao Xiayan , Guo Jianwei , Qian Guoyu , Wang Hongchen , Gong Xuzhong , Wang Dong 
Published: September 2024

Abstract

Tuning the anionic solvation structure and dynamic processes at solid‒liquid interfaces are critical yet challenging for stabilizing Zn metal anodes in Zn ion batteries. Here, we demonstrate that highly hydrated SO42− can be modulated under a strong magnetic field (MF) via the Paschen-Back effect on the O-H stretching mode, which reorients individual water molecules to manipulate Zn²⁺ solvation and protonated water clusters (H3O+). This high level of hydration was confirmed through Raman spectroscopy, molecular dynamics (MD) simulations, and ¹⁷O/¹H nuclear magnetic resonance (NMR) with coaxial insert tubes. Our findings reveal that the MF disrupts the hydrogen-bonded water structure (DDAA), leading to charge redistribution and localization onto the SO42− -4H₂O (DDA) complex, inhibiting the intra-molecular Fermi resonance of free O-H stretch water (DAA-OH) and suppressing the Zn2+-6H₂O interaction. Additionally, MD simulations and electrochemical characterizations show that these hydrated SO42−-H₂O complexes favor Zn2+ nucleation and deposition on the (002) plane, with the preferential adsorption of oxygen on Zn (002) inhibiting 2D Zn2+ diffusion. Combined with density functional theory (DFT) analysis, we demonstrate that magnetically treated ZnSO4 electrolytes exposed to a 3 T MF for 25 minutes can disrupt the Grotthuss proton-transport mechanism, suppressing H2 evolution and achieving 100% dendrite-free growth. This work highlights the critical role of magnetization pretreatment in enhancing the stability of electrochemical interfaces, offering insights for the molecular design of interfacial water in various aqueous Zn-based batteries.
PROTAC-Databank: The Present Largest Integrated Resource of PROTACs, Enabling the Enhanced DeepPROTACs 2.0 for Degradation Prediction
Authors: Bai Fang , Tian Siyuan , Tang Yilin , Li Fenglei , Li Zhaoxuan 
Published: September 2024

Abstract

Proteolysis-targeting chimera(PROTAC), is an emerging therapeutic modality with the potential to treat disease-driven proteins that emerged in the new century . Since the first PROTAC drug, ARV-110, entered Phase II clinical trials in 2019, research in this field has surged. The growing body of data has created opportunities for developing artificial intelligence (AI) methods in PROTAC design. In this study, we present the largest PROTAC database to date, named as PROTAC-Databank. Each molecule in the database is labeled with manually reviewed and uniformly formatted degradation efficiency data and protein-ligand complex structure information, providing a valuable resource for AI-driven PROTAC modeling or design. Additionally, we have enhanced the prediction accuracy of the DeepPROTACs, a widely used tool for predicting PROTAC degradation efficiency developed by our group two years ago. The update version, DeepPROTACs 2.0, which is developed based on a complete new deep learning framework. Compared with the previous version, DeepPROTACs 2.0 shows a significant improvement in prediction accuracy, increasing from 77.15% to 83.45%. The introduction of PROTAC-Databank and DeepPROTACs 2.0 offers optimized tools for PROTAC design, streamlining the screening process and reducing both time and costs.
Money transfer and monetary well-being of beneficiaries: What is the role of mobile money in the fight against poverty in Côte d’Ivoire?
Authors: Mamadou Coulibaly , Konan Kouakou Auguste 
Published: September 2024

Abstract

The poverty rate in Côte d’Ivoire is decreasingwith difficulty. Currently, 36.1% of Ivorians live below the poverty line. Moreover, social policies based on money transfers and person-to-person transfers have increased with the advent of mobile currency. This study explored the role that mobile money can play in poverty reduction policies in Côte d’Ivoire. We analyze the factors that influence this phenomenon. To do this, our methodology is based on recursive bivariate and logit estimates with a threshold effect on survey data of 1,536 people in Abidjan collected through our own care. The results show that for an individual to be able to escapemonetary poverty, he must receive a money transfer of 14,000 FCFA per month, which translates into a poverty reduction of 2.1% on average per year. The use of mobile money reduces the poverty of beneficiaries of money transfer by 0.74%. Our results suggest that, under the Productive Social Safety Net Project, it would be more effective to increase the numberof transfers to poor households to 42,000 FCFA per quarter rather than 36,000 FCFA per quarter. while promoting the spread of mobile money services for money transfers between individuals, including by offering promotional offers for transfers of a minimum amount of 14,000 FCFA.
An Uncommon and Lethal Scenario: Neurogenic Pulmonary Edema, Impaired Left Ventricular Function, and Resistant Ventricular Fibrillation Following Grade 3 Subarachnoid Hemorrhage - a Unique Case Report.
Authors: NMM Risly , JF Sahana , Weerasinghe Dinesh , M Thilini 
Published: September 2024

Abstract

Background: Neurogenic pulmonary edema (NPE) is a rare but serious complication of acute brain injuries, including subarachnoid hemorrhage (SAH). The early recognition and management of NPE in the context of SAH are crucial for improving patient outcomes. This case report discusses a fatal presentation of SAH complicated by acute NPE, cardiovascular compromise, and fatal arrhythmia.
Case Presentation: A previously healthy 40-year-old woman was urgently transferred to the Emergency Treatment Unit at Anuradhapura Teaching Hospital after experiencing sudden loss of consciousness, generalized seizures, and severe respiratory distress. Initial assessment revealed a blocked airway due to frothy secretions, labored breathing with low oxygen saturation, and hemodynamic instability. Neurological examination indicated a Glasgow Coma Scale score of 7. Point-of-care ultrasound (POCUS) and imaging studies confirmed pulmonary edema, reduced cardiac ejection fraction, and a Grade IV subarachnoid hemorrhage according to the Fisher scale. Despite aggressive medical interventions, including intubation, ventilation, and inotropic support, the patient’s condition deteriorated, leading to ventricular fibrillation and, ultimately, her demise.
Discussion: The case highlights the importance of early identification and prompt management of NPE in patients with SAH. The pathophysiology of NPE involves complex interactions between neurogenic, hemodynamic, and inflammatory factors, which can lead to rapid clinical decline. ECG changes, such as widespread ST-segment depression, may serve as early indicators of acute pulmonary complications in SAH patients. Multidisciplinary collaboration, standardized treatment protocols, and continuous quality improvement initiatives are recommended to enhance the management of similar cases.
Conclusion: This case underscores the critical need for heightened awareness and early intervention in the management of NPE associated with SAH. Timely, coordinated care may improve outcomes and reduce mortality in patients with this challenging clinical presentation.