bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastroschisis in a fetus with a congenital neuroblastoma: Association or coincidence?
Authors: Rosa Rafael F.M. , Michelon Laura , Masiero Átila , Faria Adyr E.V. , Souza Vanessa F. De , Dietrich Cristine , Targa Luciano V. , Provenzi Valentina O. , Pires Silvana R.S. , Zen Paulo R.G. 
Published: February 2016

BackgroundGastroschisis is the most common abdominal wall defect. It is characterized by herniation of the intestine and other abdominal organs through a defect in the abdominal wall. Neuroblastoma is the most common malignant tumor observed during the neonatal period. It is a neuroendocrine tumor derived from neural crest cells that develops into the adrenal gland.CaseWe report on the undescribed association between gastrochisis and congenital neuroblastoma, diagnosised during the prenatal period. The mother was a 20‐year‐old healthy pregnant woman in her second pregnancy. Obstetric ultrasound examination showed a fetus presenting an abdominal wall defect on the right side of the umbilical cord, compatible with gastroschisis, and a hyperechogenic and spherical solid lesion on the left adrenal gland. Fetal magnetic resonance imaging disclosed similar features associated to a heterogeneous aspect of the liver. The diagnosis of metastatic neuroblastoma was confirmed after birth through liver biopsy. At 2 days of life, the prothrombrin time was abnormal, and the patient needed vitamin K.ConclusionWe cannot rule out the possibility that a clotting defect, commonly observed in disseminated malignancies such as a metastatic neuroblastoma may be associated with the etiology of the gastroschisis, as this defect may result from a thrombosis occurring around 3 to 4 weeks of gestation, a period when neuroblasts development occurs into the adrenal medulla. However, we cannot exclude the possibility that both events may have occurred simultaneously by chance. Birth Defects Research (Part A) 106:208–212, 2016. © 2016 Wiley Periodicals, Inc.
A Single‐Source Precursor Approach to Self‐Supported Nickel–Manganese‐Based Catalysts with Improved Stability for Effective Low‐Temperature Dry Reforming of Methane
Authors: Menezes Prashanth W. , Indra Arindam , Littlewood Patrick , Göbel Caren , Schomäcker Reinhard , Driess Matthias 
Published: February 2016

AbstractSelf‐supported nickel–manganese‐based catalysts were synthesized from heterobimetallic nickel manganese oxalate precursors via a versatile reverse micelle approach. The precursors were subjected to thermal degradation (400 °C) in the presence of synthetic air to form respective metal oxides, which were treated under hydrogen (500 °C) to form Ni2MnO4–O2–H2, Ni6MnO8–O2–H2 and NiO–O2–H2. Similarly, the precursors were also treated directly under hydrogen at the same temperature to form Ni2MnO4–H2 and Ni6MnO8–H2. The catalysts were extensively investigated by PXRD, SEM, TEM, XPS and BET analyses. The resulting catalysts were applied for dry reforming of methane (DRM) and exhibit better stability and resistance to coking than coprecipitated catalysts. Further, we show that addition of manganese, which is not an active catalyst for DRM alone, to nickel has a significant promotion effect on both the activity and stability of DRM catalysts, and a Ni/Mn ratio lower than 6:1 enables optimized activity for this system.
The anorexic voice and severity of eating pathology in anorexia nervosa
Authors: Pugh Matthew , Waller Glenn 
Published: February 2016

ABSTRACTObjectiveInternal “anorexic voices” are commonly described by individuals with eating disorders. This study examines whether the perceived power and nature of that voice are related to eating pathology in anorexia nervosa.MethodSixty‐three women and one man with an ICD‐10 diagnosis of anorexia nervosa participated in this study (mean age = 27.3 years; mean BMI = 16.0). Participants completed questionnaires measuring severity of eating pathology, perceived voice power, and beliefs about voices, either at the start or during treatment.ResultsA more powerful anorexic voice was associated with more negative eating attitudes in this clinical group. However, BMI was related to a moderating effect, with the interaction of greater voice power and malevolence being associated with a lower BMI.DiscussionThese findings suggest the anorexic voice may function as a maintenance factor in anorexia nervosa. Cognitive models of hearing voices may be applicable to disorders other than psychosis. Further explorations are warranted. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:622–625).
Change in risk factors for eating disorder symptomatology in Malay students sojourning in the United Kingdom
Authors: Swami Viren 
Published: February 2016

ABSTRACTObjectiveThe purpose of this investigation was to examine change in risk for eating disorders in higher education students sojourning in the United Kingdom (UK), as well as associations between such risk and experiences in the host culture.MethodParticipants were 98 female students from Malaysia, who completed a measure of risk factors for eating disorder symptomatology (the Eating Disorder Inventory‐3 subscales of drive for thinness, body dissatisfaction, and bulimia symptoms) at two time points: two months prior to beginning their sojourn in the UK (Time 1) and four months after the sojourn began (Time 2). At Time 2, participants also completed measures of sociocultural adjustment, cultural distance between home and host cultures, and perceived discrimination in the host culture.ResultsAnalyses indicated that, compared to scores at Time 1, participants had significantly higher drive for thinness (d = 0.64), body dissatisfaction (d = 0.54), and bulimia symptoms (d = 0.29) at Time 2. Poorer sociocultural adjustment and greater perceived discrimination significantly predicted greater risk of eating disorders at Time 2.DiscussionThe stress associated with culture change may place sojourning students at risk for disordered eating. Further research is needed to determine the extent to which this risk is related to culture‐change specifically, as opposed to a general set of factors associated with transition‐related psychopathology more broadly. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:695–700)
An Enantioselective Benzofuran‐Based Receptor for Dinitrobenzoyl‐Substituted Amino Acids
Authors: de Juan Fernández Leire , Fuentes de Arriba Ángel L. , Monleón Laura M. , Rubio Omayra H. , Alcázar Montero Victoria , Rubio Luis Simón , Morán Joaquín Rodríguez 
Published: February 2016

AbstractThe easily accessible benzofuran skeleton has been used as a platform for building two synthetic receptors able to associate with carboxylic acids and dinitrobenzoyl‐substituted (DNB) amino acids. The synthesis of the benzofuran framework allows for functionalization with hydrogen bond binding sites such as amide and sulfonamide units, in a straightforward way. Substrates containing carboxylic acids are bound in the receptor cleft by multiple H‐bonding interactions. The resulting associations can be further stabilized when new interactions such as aromatic π–π stacking are established. These binding interactions become important in the recognition of the dinitrobenzoyl‐substituted amino acids, as charge transfer interactions between the electron‐deficient dinitrobenzoyl group and the rich aromatic rings in the receptors are established. Reasonable enantioselectivities have been achieved for some of the tested dinitrobenzoyl‐substituted amino acids, allowing the resolution of the racemic receptor by preparative TLC. Experimental data (NMR titrations and ROESY experiments) and molecular modelling have been used to propose reasonable structures for the diastereomeric complexes.
Microbial Electricity Generation and Isolation of Exoelectrogenic Bacteria Based on Petroleum Hydrocarbon‐contaminated Soil
Authors: Zhou Lei , Deng Dandan , Zhang Di , Chen Qi , Kang Jingquan , Fan Ningjuan , Liu Ying 
Published: February 2016

AbstractIn this study, the petroleum hydrocarbon‐contaminated soil was used as both inoculation and carbon source simultaneously to enrich exoelectrogenic bacteria for using in microbial fuel cell system and it demonstrated working output power density at around 220 mW m−2. The feasible electrochemical properties have displayed by means of cyclic voltammetry and dual‐chamber MFCs experiments. Moreover, two species of exoelectrogens were isolated belonging to Geobacter sp. and Ochrobactrum sp., respectively. This work evaluates the capability of naturally occurring petroleum‐degrading species to produce electric current in bioelectrochemical system. To the best of our knowledge, this is the first time when ecological information on electroactive, petroleum‐degrading consortium is provided.
Energy Harvesting with a Bimorph Type Piezoelectric Diaphragm Multilayer Structure and Mechanically Induced Pre‐stress
Authors: Leinonen Mikko , Juuti Jari , Jantunen Heli , Palosaari Jaakko 
Published: February 2016

AbstractThe energy harvester is constructed from four circular bimorph type piezoelectric diaphragms which are stacked and pre‐stressed with a mechanical spring. Mechanical pre‐stress keeps the voltage cancellation at a minimum between the bimorph layers and enhances the physical compression distance. This results in much higher power densities than previously reported for low‐frequency piezoelectric energy harvesting applications. The voltage output at ∼1 Hz compression frequency, which closely corresponds to the pace of human walking, gives an average power output of 11.30 mW, a very high average power density of 10.55 mW cm−3 for the piezoelectric material. The results show that bimorph type stacked and pre‐stressed piezoelectric diaphragms can provide a sufficiently compact and efficient structure to harvest useful amounts of energy; enough, for example, to power and recharge various portable devices and sensors in future applications.
Study of Donor–Acceptor–π–Acceptor Architecture Sensitizers with Benzothiazole Acceptor for Dye‐Sensitized Solar Cells
Authors: Koyyada Ganesh , Singh Surya Prakash , Bhanuprakash K. , Han Liyuan , Bedja Idriss M. , Gupta Ravindra Kumar , Islam Ashraful , Chandrasekharam M. 
Published: February 2016

AbstractA new additional benzothiazole (BT) acceptor has been introduced into metal‐free organic dyes (MCG1–MCG4) to construct donor–acceptor–π–acceptor (D‐A‐π‐A) architecture with the systematic replacement of diheteroanthracene donors and heteroaromatic π‐bridge components. BT not only facilitates effective electron transfer from the donor to the anchoring group, but also lowers the band gap. The planarity of the sensitizers induces J aggregation on TiO2, causes the redshift on TiO2, and enhances the light‐harvesting efficiency up to λ=750–800 nm. Transient absorption spectroscopy and electrochemical impedance spectroscopy have been used to understand the trends in short‐circuit current (Jsc) and open‐circuit voltage (Voc). Dye MCG4 showed a superior efficiency of 6.46 %. DFT has been complemented with experimentally determined photoelectrochemical properties. These molecules are new and support π‐bridge extension with BT for better performance of D‐A‐π‐A organic sensitizers.
Recovery of samarium (III) from aqueous solutions by poly(sodium 4‐styrenesulfonate) assisted‐ultrafiltration
Authors: Hammami Mahria , Ennigrou Dorra Jellouli , Naifer Karima Horchani , Ferid Mokhtar 
Published: February 2016

Polyelectrolyte‐assisted ultrafiltration (PAUF) was investigated for the removal of samarium (III) from aqueous solutions by using poly(sodium 4‐styrenesulfonate) (PSS) as a complexing agent. The ultrafiltration studies were carried out using a tangential cell system, equipped with a polyethersulfone membrane. Factors affecting the samarium ions retention, such as applied pressure, polyelectrolyte concentration, pH, and ionic strength, were investigated. After optimization, the best operating conditions can be obtained in order to achieve high levels of recovery. Experimental results indicate that the retention of samarium ions increases respectively with applied pressure and polyelectrolyte concentration. A maximum retention was obtained at 2 × 10−4 mol L−1 PSS concentration and 3 bars transmembrane pressure. Samarium retention by PSS assisted ultrafiltration was influenced by the pH varying from 5 to 9. The study of the ionic strength effect has shown a retention decrease with the salt concentration increase. © 2016 American Institute of Chemical Engineers Environ Prog, 35: 1091–1097, 2016
Neurobiological origin of spurious brain morphological changes: A quantitative MRI study
Authors: Lorio Sara , Kherif Ferath , Ruef Anne , Melie‐Garcia Lester , Frackowiak Richard , Ashburner John , Helms Gunther , Lutti Antoine , Draganski Bodgan 
Published: February 2016

AbstractThe high gray‐white matter contrast and spatial resolution provided by T1‐weighted magnetic resonance imaging (MRI) has made it a widely used imaging protocol for computational anatomy studies of the brain. While the image intensity in T1‐weighted images is predominantly driven by T1, other MRI parameters affect the image contrast, and hence brain morphological measures derived from the data. Because MRI parameters are correlates of different histological properties of brain tissue, this mixed contribution hampers the neurobiological interpretation of morphometry findings, an issue which remains largely ignored in the community. We acquired quantitative maps of the MRI parameters that determine signal intensities in T1‐weighted images (R1 (=1/T1), R2*, and PD) in a large cohort of healthy subjects (n = 120, aged 18–87 years). Synthetic T1‐weighted images were calculated from these quantitative maps and used to extract morphometry features—gray matter volume and cortical thickness. We observed significant variations in morphometry measures obtained from synthetic images derived from different subsets of MRI parameters. We also detected a modulation of these variations by age. Our findings highlight the impact of microstructural properties of brain tissue—myelination, iron, and water content—on automated measures of brain morphology and show that microstructural tissue changes might lead to the detection of spurious morphological changes in computational anatomy studies. They motivate a review of previous morphological results obtained from standard anatomical MRI images and highlight the value of quantitative MRI data for the inference of microscopic tissue changes in the healthy and diseased brain. Hum Brain Mapp 37:1801–1815, 2016. © 2016 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma
Authors: Kim Ki Tae , Kim Bo‐Sung , Kim Ju Han 
Published: February 2016

AbstractBackgroundThe purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (FAT1) and determine the prognostic significance of FAT1 mutation for overall survival in patients with human papillomavirus (HPV)‐negative head and neck squamous cell carcinoma (HNSCC).MethodsData were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. FAT1 mutational status was determined in 234 and 37 patients with HPV‐negative HNSCC, respectively, and overall survival analysis was performed. For comparison, HPV‐positive patients were also analyzed for overall survival.ResultsMost of the identified nonsynonymous somatic FAT1 mutations were loss‐of‐function mutations. FAT1 mutation was significantly associated with better overall survival in HPV‐negative patients from both the TCGA cohort (p = .026) and the ICGC cohort (p = .047), but not in HPV‐positive patients.ConclusionFAT1 mutational status is a strong independent prognostic factor in patients with HPV‐negative HNSCC. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 38: E2021–E2029, 2016
Impact of preoperative embolization on the outcomes of carotid body tumor surgery: A meta‐analysis and review of the literature
Authors: Abu‐Ghanem Sara , Yehuda Moshe , Carmel Narin Nard , Abergel Avraham , Fliss Dan M. 
Published: February 2016

AbstractBackgroundThere is no consensus on the impact of preoperative embolization (EMB) on the surgical outcomes of carotid body tumor (CBT) resections.MethodsA systematic review and a meta‐analysis were conducted to clarify the role of preoperative EMB in patients undergoing surgical removal of CBTs.ResultsFifteen studies with a total number of 470 patients met the inclusion criteria. The results of the meta‐analysis showed that there is no significant difference in estimated blood loss, operative time, length of hospital stay, or risks of cranial nerve injury, vascular injury, and stroke between the EMB and nonembolization (NEMB) groups.ConclusionThis systemic review and meta‐analysis demonstrate that preoperative EMB does not confer any operative or postoperative advantage in patients scheduled for CBT surgery. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2386–E2394, 2016
Role of endoscopic surgery in the management of sinonasal and skull base schwannomas
Authors: Karligkiotis Apostolos , Turri‐Zanoni Mario , Sica Eleonora , Facco Carla , Freguia Stefania , Mercuri Anna , Pistochini Andrea , Bignami Maurizio , Castelnuovo Paolo 
Published: February 2016

AbstractBackgroundThe purpose of this study was to report our experience with the endoscopic management of sinonasal schwannomas, analyzing the advantages, limitations, and outcomes of the technique.MethodsA retrospective analysis was carried out on 11 patients treated endoscopically between 2000 and 2014 at a single institution.ResultsEight patients underwent an exclusive endoscopic endonasal approach, whereas, in 3 patients, an osteoplastic flap was combined because of massive or lateral frontal sinus involvement. The tumor extended into the orbit in 5 cases, and involved the skull base in 5 patients who required a concomitant endoscopic duraplasty. No evidence of disease was observed in 10 patients after a mean follow‐up of 90.1 months (range, 14–189 months). One patient was alive with persistence of disease, although asymptomatic.ConclusionThe endoscopic endonasal approach is a valid alternative for the vast majority of sinonasal schwannomas with minimal morbidity for the patient. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2074–E2082, 2016
A randomized, double‐blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally
Authors: Solomon Todd M. , Leech Jarrett , deBros Guy B. , Murphy Cynthia A. , Budson Andrew E. , Vassey Elizabeth A. , Solomon Paul R. 
Published: February 2016

ObjectiveAlpha BRAIN® is a nootropic supplement that purports to enhance cognitive functioning in healthy adults. The goal of this study was to investigate the efficacy of this self‐described cognitive enhancing nootropic on cognitive functioning in a group of healthy adults by utilizing a randomized, double blind, placebo‐controlled design.MethodsA total of 63‐treatment naïve individuals between 18 and 35 years of age completed the randomized, double‐blind, placebo controlled trial. All participants completed a 2‐week placebo run in before receiving active product, Alpha BRAIN® or new placebo, for 6 weeks. Participants undertook a battery of neuropsychological tests at randomization and at study completion. Primary outcome measures included a battery of neuropsychological tests and measures of sleep.ResultsCompared with placebo, Alpha BRAIN® significantly improved on tasks of delayed verbal recall and executive functioning. Results also indicated significant time‐by‐group interaction in delayed verbal recall for the Alpha BRAIN® group.ConclusionsThe use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study.
Small Ring Compounds and N‐oxides: Cycloadditions and Related Processes
Authors: Tabolin Andrey A. , Ioffe Sema L. 
Published: February 2016

AbstractThe review discusses the possibilities for reactions of small ring compounds (cyclopropanes, cyclobutanes, and their heteroanalogs) with various N‐oxides (nitrones, nitronates, nitrile oxides, etc.). Two major paths include: formal cycloadditions of small cycles with N‐oxide possessing dipoles, and [3+2] cycloadditions of small cyclic alkenes with N‐oxides, followed by N−O bond cleavage‐assisted rearrangement/ring opening.
CAV1 Prevents Gallbladder Cholesterol Crystallization by Regulating Biosynthesis and Transport of Bile Salts
Authors: Xu Guoqiang , Li Yiqiao , Jiang Xin , Chen Hongtan 
Published: February 2016

ABSTRACTCholesterol gallstone disease (CGD) is a hepatobiliary disorder which results from a biochemical imbalance in the gallbladder bile. Here we show that loss of CAV1 sensitized mice to lithogenic diet‐induced gallbladder cholesterol crystallization, which was associated with dysregulation of several hepatic transporters that efflux cholesterol, phospholipids, and bile salts. The combined effect of increased biliary cholesterol concentration and decreased biliary bile salt secretion in CAV1−/− mice led to an increased cholesterol saturation index and the formation of cholesterol crystals. At the signaling level, the ERK/AP‐1 pathway seems to mediate the effects of CAV1 on biliary BA homeostasis and might be developed as a therapeutic target for CGD. We propose that CAV1 is an anti‐lithogenic factor and that the CAV1−/− mice may offer a convenient CGD model to develop therapeutic interventions for this disease. J. Cell. Biochem. 117: 2118–2127, 2016. © 2016 Wiley Periodicals, Inc.
Docosahexaenoic acid‐supplementation prior to fasting prevents muscle atrophy in mice
Authors: Deval Christiane , Capel Frédéric , Laillet Brigitte , Polge Cécile , Béchet Daniel , Taillandier Daniel , Attaix Didier , Combaret Lydie 
Published: February 2016

AbstractBackgroundMuscle wasting prevails in numerous diseases (e.g. diabetes, cardiovascular and kidney diseases, COPD,…) and increases healthcare costs. A major clinical issue is to devise new strategies preventing muscle wasting. We hypothesized that 8‐week docosahexaenoic acid (DHA) supplementation prior to fasting may preserve muscle mass in vivo.MethodsSix‐week‐old C57BL/6 mice were fed a DHA‐enriched or a control diet for 8 weeks and then fasted for 48 h.ResultsFeeding mice a DHA‐enriched diet prior to fasting elevated muscle glycogen contents, reduced muscle wasting, blocked the 55% decrease in Akt phosphorylation, and reduced by 30–40% the activation of AMPK, ubiquitination, or autophagy. The DHA‐enriched diet fully abolished the fasting induced‐messenger RNA (mRNA) over‐expression of the endocannabinoid receptor‐1. Finally, DHA prevented or modulated the fasting‐dependent increase in muscle mRNA levels for Rab18, PLD1, and perilipins, which determine the formation and fate of lipid droplets, in parallel with muscle sparing.ConclusionsThese data suggest that 8‐week DHA supplementation increased energy stores that can be efficiently mobilized, and thus preserved muscle mass in response to fasting through the regulation of Akt‐ and AMPK‐dependent signalling pathways for reducing proteolysis activation. Whether a nutritional strategy aiming at increasing energy status may shorten recovery periods in clinical settings remains to be tested.