bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Alzheimer's disease pathophysiology based on cortical thickness patterns
Authors: Hwang Jihye , Kim Chan Mi , Jeon Seun , Lee Jong Min , Hong Yun Jeong , Roh Jee Hoon , Lee Jae‐Hong , Koh Jae‐Young , Na Duk L. ,   Alzheimer's Disease Neuroimaging Initiative
Published: December 2015

AbstractIntroductionRecent studies have shown that pathologically defined subtypes of Alzheimer's disease (AD) represent distinctive atrophy patterns and clinical characteristics. We investigated whether a cortical thickness–based clustering method can reflect such findings.MethodsA total of 77 AD subjects from the Alzheimer's Disease Neuroimaging Initiative 2 data set who underwent 3‐T magnetic resonance imaging, [18F]‐fluorodeoxyglucose‐positron emission tomography (PET), [18F]‐Florbetapir PET, and cerebrospinal fluid (CSF) tests were enrolled. After clustering based on cortical thickness, diverse imaging and biofluid biomarkers were compared between these groups.ResultsThree cortical thinning patterns were noted: medial temporal (MT; 19.5%), diffuse (55.8%), and parietal dominant (P; 24.7%) atrophy subtypes. The P subtype was the youngest and represented more glucose hypometabolism in the parietal and occipital cortices and marked amyloid‐beta accumulation in most brain regions. The MT subtype revealed more glucose hypometabolism in the left hippocampus and bilateral frontal cortices and less performance in memory tests. CSF test results did not differ between the groups.DiscussionCortical thickness patterns can reflect pathophysiological and clinical changes in AD.
Repeated systemic inflammation was associated with cognitive deficits in older Britons
Authors: Tampubolon Gindo 
Published: December 2015

AbstractIntroductionThe relationship of C‐reactive protein (CRP) to cognition in the older old group (≥75 years) has recently been found positive on both sides of the Atlantic. We hypothesized that higher levels of CRP and fibrinogen are related to worse episodic memory throughout later life (≥50 years).MethodsData are drawn from older Britons free of dementias in the English Longitudinal Study of Aging 2004–2013. We applied growth trajectory models to repeated observations of episodic memory, CRP, and fibrinogen levels (and sociodemographic confounders). We accounted for practice effects in repeated tests of cognition.ResultsHigher levels of both inflammatory markers were associated with worse episodic memory, where a fibrinogen effect is evident throughout later life (coefficient −0.154; 95% confidence interval [CI] −0.254 to −0.054). Most importantly, the CRP effect is strongly negative among the older old group (coefficient −0.179; CI −0.320 to −0.038).DiscussionHigher levels of fibrinogen are detrimental to older people's cognition, and among the older old, raised CRP levels are comparably deleterious. Repeated measures of inflammation can be considered in clinical practice as part of a response to the challenge of dementias.
Well-Being Policy: What Standard of Well-Being?
Authors: HAYBRON DANIEL M. , TIBERIUS VALERIE 
Published: December 2015

ABSTRACT:This paper examines the norms that should guide policies aimed at promoting happiness or, more broadly, well-being. In particular, we take up the question of which conception of well-being should govern well-being policy (WBP), assuming some such policies to be legitimate. In answer, we lay out a case for ‘pragmatic subjectivism’: given widely accepted principles of respect for persons, well-being policy may not assume any view of well-being, subjectivist or objectivist. Rather, it should promote what its intended beneficiaries see as good for them: pleasure for hedonists, excellence for Aristotelians, etc. Specifically, well-being policy should promote citizens’ ‘personal welfare values’: those values—and not mere preferences—that individuals see as bearing on their well-being. Finally, we briefly consider how pragmatic subjectivism works in practice. While our discussion takes for granted the legitimacy of well-being policy, we suggest that pragmatic subjectivism strengthens the case for such policy.
An Ontology of Ideas
Authors: CRAY WESLEY D. , SCHROEDER TIMOTHY 
Published: December 2015

ABSTRACT:Philosophers often talk about and engage with ideas. Scientists, artists, and historians do, too. But what is an idea? In this paper, we first motivate the desire for an ontology of ideas before discussing what conditions a candidate ontology would have to satisfy to be minimally adequate. We then offer our own account of the ontology of ideas and consider various strategies for specifying the underlying metaphysics of the account. We conclude with a discussion of potential future work to be done on the ontology of ideas.
Necessary Moral Principles
Authors: SWINBURNE RICHARD 
Published: December 2015

ABSTRACT:Moral realism entails that there are metaphysically necessary moral principles of the form ‘all actions of nonmoral kind Z are morally good’; being discoverable a priori, these must be (in a wide sense) logically necessary. This article seeks to justify this apparently puzzling consequence. A sentence expresses a logically necessary proposition iff its negation entails a contradiction. The method of reflective equilibrium assumes that the simplest account of the apparently correct use of sentences of some type in paradigm examples is probably logically necessary. An account is simple insofar as it uses few predicates designating properties easily recognizable in many different kinds of paradigm examples. I illustrate how reflective equilibrium uses these criteria to discover logically necessary nonmoral propositions such as ‘if S remembers doing X, S believes that he did X’ and ‘if it is scarlet, it is red’. I then illustrate how exactly the same procedures can lead us from paradigm examples of apparently true sentences asserting that actions of some kind are good to discovering moral principles. I advance the contingent hypothesis that most contemporary humans, although they initially disagree about moral issues, have derived from different paradigm examples the same concept of moral goodness, which will ensure that the use of reflective equilibrium will lead to eventual agreement about moral issues. That strongly suggests that the moral principles eventually reached by reflective equilibrium are logically necessary ones.
The Hungarian rootes-in language and cognition
Authors: KÖVECSES ZOLTÁN 
Published: December 2015

abstractMy goal in the paper is to examine the significance of a root morpheme in language and cognition in three interconnected areas; in the creation of words; in meaning making; and in conceptual structure. I use the Hungarian rootes-, meaning ‘fall’, for demonstration – a root that occurs in over 100 Hungarian words. First, I examine the issue of the conceptual–semantic relationship between the various word meanings in which this root can be found. Second, I explore the potential cognitive status of the root in Hungarian, and possibly in other languages (such as English). Third, I compare the meanings in whiches-occurs in Hungarian to the nearest counterparts of these words in English. Fourth, I investigate the potential role of the rootes-in organizing conceptual structure.
IX. A Dissertation on the Monument of Edward the Confessor. By Mr. Vertue, 1736
Authors: Vertue  
Published: December 2015

As Rapin has made mention of an old inscription on the shrine of K. Edward the Confessor, in Westminster abby, when first erected; it is to be observed, that that which now is there differeth from it, having, as it is said, been wrote, and put in lieu of the former in the reign of K. Richard II, or later. The inscription, as printed in several books, and particularly to be seen in the print of that monument, engraved for the Society of Antiquaries, from a drawing by the late Mr. Talman, is as follows,Omnibus insignis virtutum laudibus heros,Sanctus Edwardus Confessor; rex venerandus,Quinto die Januarii moriens super aethera scandit.Sursum corda.Moritur anno Domini mlxv.
XXVIII. On the Trajan and Antonine Pillars at Rome, by Martin Folkes, Esquire
Authors: Folkes Martin 
Published: December 2015

The Trajan column at Rome, is all of white marble, and consists of 30 stones, whereof 8 make the pedestal, 19 the pillar, and 3 the basis of the statue that stands on the top.The side of the lowest plinth of the pedestal contains 20 English feet and three inches.
XLVI. A Roman Inscription upon a Rock at Shawk Quarries, in Great Dalston, Cumberland, A. D. 1766
Authors: Carlisle Cha. 
Published: December 2015

The drawing I now lay before you, contains a Roman inscription on a rock, situated at a place called Shawk Quarries, near Rose Castle in Cumberland, which has hitherto been overlooked by all our antiquaries, even by my famous predecessor Bishop Nicholson, though so near to his own mansion, and within his own manor of Dalston: I read it thus,LEGIONIS SECVNDAE AVGVSTAEMILITES POSVERVNT.COHORS TERTIA–COHORS QVARTA.
CONSIDERING EQUITY IN HEALTH TECHNOLOGY ASSESSMENT: AN EXPLORATORY ANALYSIS OF AGENCY PRACTICES
Authors: Panteli Dimitra , Kreis Julia , Busse Reinhard 
Published: December 2015

Objectives: Equity is one of the founding principles in most healthcare systems. Financial constraints entail an increased risk of exacerbating inequities and a greater need for evidence-based decisions. It is, therefore, both important and timely to enquire how equity can be addressed in health technology assessment (HTA) practice. We aimed to explore related practices from a broad range of HTA agencies, identify exemplary approaches and common concerns, and offer insights for future considerations.Methods: HTA agencies for which both methodological guides and HTA reports were publicly available were selected from an initial comprehensive pool. Information was extracted on issues ranging from a general commitment to fairness to specific measures targeting both methodological and process-related elements.Results: Methodological documents and ninety-eight reports from nineteen agencies were analyzed. Our findings indicate that equity was not a standard consideration in HTA report production. The nature of specific approaches and the amount of resources invested into including an equity perspective varied considerably. Specific measures (e.g., appropriate information sources, analytical tools, and schemes) were mentioned by almost half of the agencies analyzed. Albeit sporadic, both horizontal and vertical equity considerations were identified in included HTA reports.Conclusions: While varying legal contexts and institutional principles can lead to different interpretations of equity at the decision point, a combination of methodological and process-related practices could contribute to more equity-sensitive evaluations, especially in conjunction with enhanced dissemination of existing methodological tools. Networking initiatives on behalf of existing collaborating platforms could play an important role in this direction.
Time constraints on market activity and the balance of power in medieval Liège
Authors: WILKIN ALEXIS 
Published: December 2015

ABSTRACTThis article focuses on a little scrutinised aspect of the regulation of markets for food in the central middle ages, using a case study, the town of Liège, in addition to other examples from the southern Low Countries. It aims to demonstrate how regulations concerning the timing of the marketing of foodstuffs operated in order to guarantee privileged access to some categories of urban inhabitants. This institutional management of time in the market was a function of a specific balance of power which in turn shaped economic, social and political outcomes.
CERAMIC HISTORY, CERAMIC CHANGE, AND ARCHITECTURAL SEQUENCE AT ACANMUL, CAMPECHE: A LOCAL CHRONICLE AND ITS REGIONAL IMPLICATIONS
Authors: Ball Joseph W. , Taschek Jennifer T. 
Published: December 2015

AbstractAcanmul is a medium-size center located at the north end of the Bay of Campeche about 25 km northeast of the city of Campeche. Between 1999 and 2005, three independent sets of investigations and major architectural consolidation were carried out at the center by archaeologists from the Universidad Autónoma de Campeche (UAC), the Instituto Nacional de Antropología e Historia (INAH), Centro Regional de Campeche, and UAC in collaboration with San Diego State University. These efforts produced a wealth of new information on the archaeology of the central Campeche coast, including new insights into the emergence and evolution of the northern slateware tradition and the architectural history of the central coast from Preclassic through Postclassic times. New data concerning changing relationships through time of the central coast Maya to both the interior central and southern lowlands and to the northern plains also were documented, as was the mid ninth century sacking of the center. This article synthesizes the findings of the three separate institutional efforts at Acanmul and offers a number of new cultural historical scenarios and hypotheses based on them.
REVISITING MONKEYS ON POTS: A CONTEXTUAL CONSIDERATION OF PRIMATE IMAGERY ON CLASSIC LOWLAND MAYA POTTERY
Authors: Rice Prudence M. , South Katherine E. 
Published: December 2015

AbstractFour species of monkeys may have lived in the Maya region in pre-Columbian times: two howler monkey species, the spider monkey, and possibly the capuchin. Simians also played an important role in Maya creation myth and cosmology, and are frequently represented on Maya pottery and in glyphic texts. Scholars disagree, however, on which monkeys are depicted. Here we provide an analysis of 142 monkey images on 97 pots, focusing especially on Classic-period lowland polychromes. Multiple physical characteristics of the primates are considered, along with cultural traits, to provide appropriate biological and cultural contexts and artistic conventions necessary to their interpretation. Besides the well-known scribal roles (attributed to howlers and “Monkey-Men”), we conclude that monkeys commonly take on pictorial and non-pictorial roles that involve carrying or bringing goods such as tribute or cacao. In contexts of liminality, these creatures are often charged with transcending natural and social realms.
LOS SITIOS RURALES Y LA ESTRATEGIA EXPANSIONISTA DEL ESTADO TEOTIHUACANO PARA LA CAPTACION DE RECURSOS EN LA CUENCA DE MÉXICO
Authors: García Chávez Raúl E. , Gamboa Cabezas Luis Manuel , Saldaña Nadia Vélez 
Published: December 2015

RESUMENDesde el inicio del siglo XX y después de los primeros recorridos que realizó Manuel Gamio, por el área de la Cuenca de México, se hizo patente que existían muchos sitios que de alguna forma estaban relacionados con Teotihuacan. Pero al no haber una forma sistemática de describirlos, solo algunos de esos sitios como Azcapotzalco (Gamio 1972) fueron reportados y no fue hasta los años sesenta de siglo XX, con los recorridos de superficie iniciados por Sanders y colegas en la Cuenca de México, que sabemos que Teotihuacan tuvo un ámbito rural a la manera de sitios satélite. Desafortunadamente, el conocimiento sobre la ubicación de los sitios rurales, no ha impedido que muchos de estos sitios, sean alterados o destruidos por las obras de construcción de autopistas, centros comerciales, áreas habitacionales y obras de infraestructura urbana en el área metropolitana de la ciudad de México. Es debido a esta situación, que la mayoría de los casos presentados en este trabajo corresponden a sitios que fueron explorados através de operaciones de salvamento arqueológico por quienes esto escriben, como miembros del Instituto Nacional de Antropología e Historia de México. Los restos arqueológicos que han sobrevivido hasta nuestros días muestran una parte de la amplia gama de sitios rurales teotihuacanos que existieron en el área de la Cuenca de México y cuyo estudio es importante para la determinación de los procesos de desarrollo de las sociedades del clásico. Se trata de sitios con variaciones en sus tamaños, con diferentes calidades constructivas y que aparecieron en diferentes fases entre los años d.C. 100 a d.C. 500 En este artículo describimos algunas características de los sitios intervenidos y estudiados, tratando de relacionar y comparar la información con la que existe sobre el gran centro urbano de Teotihuacan, por lo que aquí presentaremos una síntesis con los datos que están disponibles, para entender parte de los procesos de desarrollo de la sociedad del clásico en el altiplano de Mesoamérica.
Anne M. Thompson Receives 2015 Roger Revelle Medal
Authors:   AGU
Published: December 2015

Anne M. Thompson was awarded the 2015 Roger Revelle Medal at the American Geophysical Union Fall Meeting Honors Ceremony, held on 16 December 2015 in San Francisco, Calif. The medal is for "outstanding contributions in atmospheric sciences, atmosphere-ocean coupling, atmosphere-land coupling, biogeochemical cycles, climate, or related aspects of the Earth system."
Reconstructing representations of dynamic visual objects in early visual cortex
Authors: Chong Edmund , Familiar Ariana M. , Shim Won Mok 
Published: December 2015

Significance
The visual system is often presented with degraded and partial visual information; thus, it must extensively fill in details not present in the physical input. Does the visual system fill in object-specific information as an object’s features change in motion? Here, we show that object-specific features (orientation) can be reconstructed from neural activity in early visual cortex (V1) while objects undergo dynamic transformations. Furthermore, our results suggest that this information is not generated by averaging the physically present stimuli or by mechanisms involved in visual imagery, which also requires internal reconstruction of information not physically present. Our study provides evidence that V1 plays a unique role in dynamic filling-in of integrated visual information during kinetic object transformations via feedback signals.
Early Lapita skeletons from Vanuatu show Polynesian craniofacial shape: Implications for Remote Oceanic settlement and Lapita origins
Authors: Valentin Frédérique , Détroit Florent , Spriggs Matthew J. T. , Bedford Stuart 
Published: December 2015

Significance
The question of the origin of Pacific Islanders has exercised scientists since the first explorers’ voyages of the 16th century. Physical resemblance between Polynesians and Asian populations was detected, but in between were the islands of Melanesia, inhabited largely by people of different phenotype. However, the Lapita culture bridged this geographical divide 3,000 y ago. Morphological studies of early Lapita colonists from Teouma, Vanuatu align them with present-day Polynesian and Asian populations, whereas skeletal remains of later generations show a more Melanesian phenotype predominating. We suggest that migration streams from already-inhabited parts of Melanesia dating from the late-Lapita phase ultimately dominated the original Polynesian phenotype in eastern Melanesia, but not in Polynesia, which became relatively isolated soon after initial settlement.
Drivers of household food availability in sub-Saharan Africa based on big data from small farms
Authors: Frelat Romain , Lopez-Ridaura Santiago , Giller Ken E. , Herrero Mario , Douxchamps Sabine , Djurfeldt Agnes Andersson , Erenstein Olaf , Henderson Ben , Kassie Menale , Paul Birthe K. , Rigolot Cyrille , Ritzema Randall S. , Rodriguez Daniel , van Asten Piet J. A. , van Wijk Mark T. 
Published: December 2015

Significance
We collated a unique dataset covering land use and production data of more than 13,000 smallholder farm households in 93 sites in 17 countries across sub-Saharan Africa. The study quantifies the importance of off-farm income and market conditions across sites differing strongly in agroecology and derives generally applicable threshold values that determine whether farm households have enough food available to feed their families. These results show there is a strong need for multisectoral policy harmonization and incentives and improved interconnectedness of people to urban centers and diversification of employment sources, rather than a singular focus on agricultural development of smallholder farmers in sub-Saharan Africa.
Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex
Authors: Hua Guoqiang , Ganti Krishna Priya , Chambon Pierre 
Published: December 2015

Significance
The antiinflammatory property of natural glucocorticoids (GCs) was demonstrated more than 60 years ago. Since then, synthetic GCs have been widely used to combat inflammatory and allergic disorders. However, multiple severe undesirable side effects associated with long-term GC treatments, as well as induction of glucocorticoid resistance associated with such treatments, limit their therapeutic usefulness. In the present study, we unveiled the molecular mechanism underlying the GC-induced GC receptor (GR)-mediated tethered indirect transrepression. This knowledge paves the way to the future educated design and screening of drugs, collectively named selective GR agonists, which would exhibit the major therapeutically beneficial properties of GCs, but would be devoid of undesirable debilitating effects upon prolonged GC therapy.
AFS Position Paper and Policy on Mining and Fossil Fuel Extraction
Authors: Hughes Robert M. , Amezcua Felipe , Chambers David M. , Daniel Wesley M. , Franks James S. , Franzin William , MacDonald Donald , Merriam Eric , Neall George , Santos Pompeu Paulo , Reynolds Lou , Woody Carol Ann 
Published: December 2015

Abstract
Following a four-year period of writing, member comment, and multiple revisions, the AFS Position Paper and Policy on Mining and Fossil Fuel Extraction was approved unanimously by the membership at the Society's annual business meeting August 19, 2015, in Portland, Oregon. The entire document can be read at fisheries.org/policy_statements; a brief summary follows.
BSAFER: A Web-Based Intervention for Drug use and Intimate Partner Violence Demonstrates Feasibility and Acceptability among Women in the Emergency Department
Authors: Choo Esther K. , Zlotnick Caron , Strong David R. , Squires Daniel D. , Tapé Chantal , Mello Michael J. 
Published: December 2015

Background: Addressing violence along with drug use change goals is critical for women with coexisting intimate partner violence (IPV) and substance use disorders (SUDs). Methods: This was an acceptability and feasibility study of BSAFER, a brief Web-based program and booster phone call addressing violence and drug use. A screening survey identified women with recent drug use and IPV in the emergency department (ED). Participants were randomized to BSAFER or a Web-based control program and booster call providing education about home fire safety. Program completion, usability, satisfaction, and motivational interviewing (MI) adherence were primary outcomes. Drug use and IPV outcomes were measured at baseline, 1 month, and 3 months. Results: Forty women were enrolled (21 BSAFER, 19 control); 50% were nonwhite and mean age was 30 years. The most commonly used drugs were marijuana (88%) and cocaine (30%); 45% reported physical abuse, and 33% reported severe combined physical and sexual abuse. Thirty-nine (98%) completed the Web program, 30 (75%) completed the booster, and 29 (73%) completed the 3-month follow-up. Mean System Usability Scale (SUS) for the BSAFER Web program was 84 (95% confidence interval [CI]: 78–89) of 100; mean Client Satisfaction Questionnaire (CSQ-8) was 28 (95% CI: 26–29) of 32. MI adherence scores were high and similar for both the Web program and the booster. Both intervention and control groups had small mean decreases in weekly drug use days (0.7 vs. 1.5 days); participants using drugs other than marijuana demonstrated greater average reductions in drug use than those using marijuana only. Conclusions: An ED Web-based intervention for SUDs and IPV in women demonstrated feasibility and acceptability. Future studies will examine efficacy of the BSAFER program and investigate whether specific subgroups of drug using women may be most responsive to ED-based Web interventions.