bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic cellular phenotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents
Authors: Monzel Cornelia , Becker Alexandra S. , Saffrich Rainer , Wuchter Patrick , Eckstein Volker , Ho Anthony D. , Tanaka Motomu 
Published: January 2018

AbstractEfficient mobilization of hematopoietic stem and progenitor cells (HSPC) is one of the most crucial issues for harvesting an adequate amount of peripheral HSPC for successful clinical transplantation. Applying well-defined surrogate models for the bone marrow niche, live cell imaging techniques, and novel tools in statistical physics, we have quantified the functionality of two mobilization agents that have been applied in the clinic, NOX-A12 and AMD3100 (plerixafor), as compared to a naturally occurring chemokine in the bone marrow, SDF1α. We found that NOX-A12, an L-enantiomeric RNA oligonucleotide to SDF1, significantly reduced the adhesion of HSPC to the niche surface mediated via the CXCR4-SDF1α axis, and stretched the migration trajectories of the HSPC. We found that the stretching of trajectories by NOX-A12 was more prominent than that by SDF1α. In contrast, plerixafor exhibited no detectable interference with adhesion and migration. We also found that the deformation of HSPC induced by SDF1α or plerixafor was also drastically suppressed in the presence of NOX-A12. This novel technology of quantitative assessment of “dynamic phenotypes” by physical tools has therefore enabled us to define different mechanisms of function for various extrinsic factors compared to naturally occurring chemokines.
Spin-Orbit Effects on the Dynamical Properties of Polarons in Graphene Nanoribbons
Authors: Ribeiro Luiz Antônio , da Silva Gesiel Gomes , de Sousa Rafael Timóteo , de Almeida Fonseca Antonio Luciano , da Cunha Wiliam Ferreira , Silva Geraldo Magela e 
Published: January 2018

AbstractThe dynamical properties of polarons in armchair graphene nanoribbons (GNR) is numerically investigated in the framework of a two-dimensional tight-binding model that considers spin-orbit (SO) coupling and electron-lattice (e-l) interactions. Within this physical picture, novel polaron properties with no counterparts to results obtained from conventional tight-binding models are obtained. Our findings show that, depending on the system’s width, the presence of SO coupling changes the polaron’s charge localization giving rise to different degrees of stability for the charge carrier. For instance, the joint action of SO coupling and e-l interactions could promote a slight increase on the charge concentration in the center of the lattice deformation associated to the polaron. As a straightforward consequence, this process of increasing stability would lead to a depreciation in the polaron’s motion by decreasing its saturation velocity. Our finds are in good agreement with recent experimental investigations for the charge localization in GNR, mostly when it comes to the influence of SO coupling. Moreover, the contributions reported here provide a reliable method for future works to evaluate spin-orbit influence on the performance of graphene nanoribbons.
Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes
Authors: Boneschansker Leo , Jorgensen Julianne , Ellett Felix , Briscoe David M. , Irimia Daniel 
Published: January 2018

AbstractNeutrophils are key cellular components of the innate immune response and characteristically migrate from the blood towards and throughout tissues. Their migratory process is complex, guided by multiple chemoattractants released from injured tissues and microbes. How neutrophils integrate the various signals in the tissue microenvironment and mount effective responses is not fully understood. Here, we employed microfluidic mazes that replicate features of interstitial spaces and chemoattractant gradients within tissues to analyze the migration patterns of human neutrophils. We find that neutrophils respond to LTB4 and fMLF gradients with highly directional migration patterns and converge towards the source of chemoattractant. We named this directed migration pattern convergent. Moreover, neutrophils respond to gradients of C5a and IL-8 with a low-directionality migration pattern and disperse within mazes. We named this alternative migration pattern divergent. Inhibitors of MAP kinase and PI-3 kinase signaling pathways do not alter either convergent or divergent migration patterns, but reduce the number of responding neutrophils. Overlapping gradients of chemoattractants conserve the convergent and divergent migration patterns corresponding to each chemoattractant and have additive effects on the number of neutrophils migrating. These results suggest that convergent and divergent neutrophil migration-patterns are the result of simultaneous activation of multiple signaling pathways.
Damage-free plasma etching of porous organo-silicate low-k using micro-capillary condensation above −50 °C
Authors: Chanson R. , Zhang L. , Naumov S. , Mankelevich Yu. A. , Tillocher T. , Lefaucheux P. , Dussart R. , Gendt S. De , Marneffe J.-F. de 
Published: January 2018

AbstractThe micro-capillary condensation of a new high boiling point organic reagent (HBPO), is studied in a periodic mesoporous oxide (PMO) with ∼34 % porosity and k-value ∼2.3. At a partial pressure of 3 mT, the onset of micro-capillary condensation occurs around +20 °C and the low-k matrix is filled at −20 °C. The condensed phase shows high stability from −50 < T ≤−35 °C, and persists in the pores when the low-k is exposed to a SF6-based plasma discharge. The etching properties of a SF6-based 150W-biased plasma discharge, using as additive this new HBPO gas, shows that negligible damage can be achieved at −50 °C, with acceptable etch rates. The evolution of the damage depth as a function of time was studied without bias and indicates that Si-CH3 loss occurs principally through Si-C dissociation by VUV photons.
A heralded and error-rejecting three-photon hyper-parallel quantum gate through cavity-assisted interactions
Authors: Liu Ji-Zhen , Wei Hai-Rui , Chen Ning-Yang 
Published: January 2018

AbstractHyper-parallel quantum computation is a promising and fruitful area of research with its high capacity and low loss rate characters. In this paper, we propose a heralded, compact, scalable, and deterministic error-rejecting scheme for implementing three-photon hyper-parallel Toffoli gate simultaneously acting on polarization and spatial degrees of freedom. It is a practical and unity gate without strong coupling strength limitations, since the undesired performances caused by the side leakage and the limited coupling strength are detected by the single-photon detectors. The success of our proposal can be heralded by the detectors, and the efficiency can be further improved by repeating the operation processes when the detectors are clicked. The evaluation of gate performance with experimental parameters shows that it is feasible with current experimental technology.
Enhancing Thermal Transport in Layered Nanomaterials
Authors: Malhotra Abhinav , Kothari Kartik , Maldovan Martin 
Published: January 2018

AbstractA comprehensive rational thermal material design paradigm requires the ability to reduce and enhance the thermal conductivities of nanomaterials. In contrast to the existing ability to reduce the thermal conductivity, methods that allow to enhance heat conduction are currently limited. Enhancing the nanoscale thermal conductivity could bring radical improvements in the performance of electronics, optoelectronics, and photovoltaic systems. Here, we show that enhanced thermal conductivities can be achieved in semiconductor nanostructures by rationally engineering phonon spectral coupling between materials. By embedding a germanium film between silicon layers, we show that its thermal conductivity can be increased by more than 100% at room temperature in contrast to a free standing thin-film. The injection of phonons from the cladding silicon layers creates the observed enhancement in thermal conductivity. We study the key factors underlying the phonon injection mechanism and find that the surface conditions and layer thicknesses play a determining role. The findings presented here will allow for the creation of nanomaterials with an increased thermal conductivity.
Phase space volume scaling of generalized entropies and anomalous diffusion scaling governed by corresponding non-linear Fokker-Planck equations
Authors: Czégel Dániel , Balogh Sámuel G. , Pollner Péter , Palla Gergely 
Published: January 2018

AbstractMany physical, biological or social systems are governed by history-dependent dynamics or are composed of strongly interacting units, showing an extreme diversity of microscopic behaviour. Macroscopically, however, they can be efficiently modeled by generalizing concepts of the theory of Markovian, ergodic and weakly interacting stochastic processes. In this paper, we model stochastic processes by a family of generalized Fokker-Planck equations whose stationary solutions are equivalent to the maximum entropy distributions according to generalized entropies. We show that at asymptotically large times and volumes, the scaling exponent of the anomalous diffusion process described by the generalized Fokker-Planck equation and the phase space volume scaling exponent of the generalized entropy bijectively determine each other via a simple algebraic relation. This implies that these basic measures characterizing the transient and the stationary behaviour of the processes provide the same information regarding the asymptotic regime, and consequently, the classification of the processes given by these two exponents coincide.
Developmental delays and psychiatric diagnoses are elevated in offspring staying in prisons with their mothers
Authors: Kutuk Meryem Ozlem , Altintas Ebru , Tufan Ali Evren , Guler Gulen , Aslan Betul , Aytan Nurgul , Kutuk Ozgur 
Published: January 2018

AbstractThe aim of the study was to describe the sociodemographic and clinical features of the mothers and their offspring staying with them in prison. The study was planned as a cross-sectional, single-center study of mothers residing in Tarsus Closed Women’s Prison of Turkish Ministry of Justice along with their 0 to 6 years old offspring. Mothers were evaluated via Structured Clinical Interview for DSM-IV Axis I Disorders. A psychologist blind to maternal evaluations applied the Denver Developmental Screening Test II (DII-DST). Children/mothers were also evaluated by a child and adolescent psychiatrist via K-SADS-PL. Twenty-four mothers with a mean age of 29.3 years were included. Most common diagnoses in mothers were nicotine abuse (n = 17, 70.8%), specific phobia (n = 8, 33.3%), alcohol abuse (n = 7, 29.2%) and substance abuse (n = 5, 20.8%). Twenty-six children (53.9% female) were living with their mothers in prison, and the mean age of those was 26.3 months. Results of the D-II-DST were abnormal in 33.3% of the children. Most common diagnoses in children were adjustment disorder (n = 7, 26.9%) separation anxiety disorder (n = 3, 11.5%) and conduct disorder (n = 2, 7.7%). A multi-center study is necessary to reach that neglected/under-served population and address the inter-generational transmission of abuse, neglect, and psychopathology.
Comparative Analysis of Natural Radioactivity Content in Tiles made in Nigeria and Imported Tiles from China
Authors: Joel E. S. , Maxwell O. , Adewoyin O. O. , Ehi-Eromosele C. O. , Saeed M. A. 
Published: January 2018

AbstractIn this investigation, natural radioactive contents in tiles manufactured in Nigeria and tiles imported from China were measured using gamma ray spectroscopy. High Purity Germanium detector was used to estimate the concentrations of some radioisotopes present in 17 samples of various tiles from Nigeria and China. The average activity concentrations of 226Ra, 232Th, and 40K for the tiles were found to be 68.2 ± 0.5; 173.9 ± 9.2 and 490 ± 15 Bq/kg and 58.2 ± 0.5, 161.5 ± 9.4 and 455.7 ± 15.1 Bq/kg for the tiles from Nigeria and China respectively. Radiological hazard indices such as absorbed dose rate, radium equivalent activity, external Hazard Index (Hex), internal Hazard Index (Hin), Annual Effective Dose (mSv/y), Gamma activity Index (Iγ) and Alpha Index (Iα) were determined for both kind of tiles from Nigeria and China. The mean values obtained were: 354.56 and 317.16 Bq/kg; 169.22 nGyh−1 and 153.92 nGyh−1; 0.95 and 0.87; 1.14 and 1.08; 1.59 mSv/y and 1.52 mSv/y; 1 and 1.15 and; 0.34 and 0.29 respectively. The mean value of radium equivalent obtained in this study is less than that of the international reference value of 370 Bq/kg for the both kind of tiles.
Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis
Authors: Peix Lizzy , Evans Iona C. , Pearce David R. , Simpson Juliet K. , Maher Toby M. , McAnulty Robin J. 
Published: January 2018

AbstractPulmonary fibrosis is a progressive scarring disorder of the lung with dismal prognosis and no curative therapy. Clusterin, an extracellular chaperone and regulator of cell functions, is reduced in bronchoalveolar lavage fluid of patients with pulmonary fibrosis. However, its distribution and role in normal and fibrotic human lung are incompletely characterized. Immunohistochemical localization of clusterin revealed strong staining associated with fibroblasts in control lung and morphologically normal areas of fibrotic lung but weak or undetectable staining in fibrotic regions and particularly fibroblastic foci. Clusterin also co-localized with elastin in vessel walls and additionally with amorphous elastin deposits in fibrotic lung. Analysis of primary lung fibroblast isolates in vitro confirmed the down-regulation of clusterin expression in fibrotic compared with control lung fibroblasts and further demonstrated that TGF-β1 is capable of down-regulating fibroblast clusterin expression. shRNA-mediated down-regulation of clusterin did not affect TGF-β1-induced fibroblast-myofibroblast differentiation but inhibited fibroblast proliferative responses and sensitized to apoptosis. Down-regulation of clusterin in fibrotic lung fibroblasts at least partly due to increased TGF-β1 may therefore represent an appropriate but insufficient response to limit fibroproliferation. Reduced expression of clusterin in the lung may also limit its extracellular chaperoning activity contributing to dysregulated deposition of extracellular matrix proteins.
Incubation temperature affects the expression of young precocial birds’ fear-related behaviours and neuroendocrine correlates
Authors: Bertin Aline , Calandreau Ludovic , Meurisse Maryse , Georgelin Marion , Palme Rupert , Lumineau Sophie , Houdelier Cécilia , Darmaillacq Anne-Sophie , Dickel Ludovic , Colson Violaine , Cornilleau Fabien , Rat Christophe , Delaveau Joel , Arnould Cécile 
Published: January 2018

AbstractThe influence of embryonic microclimate on the behavioural development of birds remains unexplored. In this study, we experimentally tested whether chronic exposure to suboptimal temperatures engendered plasticity in the expression of fear-related behaviours and in the expression of the corticotropin-releasing factor in the brains of domestic chicks (Gallus g. domesticus). We compared the neurobehavioural phenotypes of a control group of chicks incubated in an optimal thermal environment (37.8 °C) with those of a group of experimental chicks exposed chronicallyin ovoto suboptimal temperatures (27.2 °C for 1 hour twice a day). Chronic exposure to a suboptimal temperature delayed hatching and decreased growth rate and experimental chicks had higher neophobic responses than controls in novel food and novel environment tests. In addition, experimental chicks showed higher expression of corticotropin-releasing factor than did controls in nuclei of the amygdala, a structure involved in the regulation of fear-related behaviours. In this study, we report the first evidence of the strong but underappreciated role of incubation microclimate on the development of birds’ behaviour and its neurobiological correlates.
Macro-/Micro-Controlled 3D Lithium-Ion Batteries via Additive Manufacturing and Electric Field Processing
Authors: Li Jie , Liang Xinhua , Liou Frank , Park Jonghyun 
Published: January 2018

AbstractThis paper presents a new concept for making battery electrodes that can simultaneously control macro-/micro-structures and help address current energy storage technology gaps and future energy storage requirements. Modern batteries are fabricated in the form of laminated structures that are composed of randomly mixed constituent materials. This randomness in conventional methods can provide a possibility of developing new breakthrough processing techniques to build well-organized structures that can improve battery performance. In the proposed processing, an electric field (EF) controls the microstructures of manganese-based electrodes, while additive manufacturing controls macro-3D structures and the integration of both scales. The synergistic control of micro-/macro-structures is a novel concept in energy material processing that has considerable potential for providing unprecedented control of electrode structures, thereby enhancing performance. Electrochemical tests have shown that these new electrodes exhibit superior performance in their specific capacity, areal capacity, and life cycle.
Sewable soft shields for the γ-ray radiation
Authors: Gwon Seok Hyeon , Oh Jeong-Hwan , Kim Minseok , Choi Sooseok , Oh Kyu Hwan , Sun Jeong-Yun 
Published: January 2018

AbstractSoft shields are required to protect the human body during a radioactive accident. However, the modulus of most soft shields, such as HDPE and epoxy, is high, thereby making it difficult to process them in wearable forms like gloves and clothes. We synthesized a soft shield based on a hydrogel that is very compliant, stretchable, and biocompatible. The shields were fabricated by integrating γ-ray-shield particles into hydrogels with an interpenetrating network. The soft shields containing 3.33 M of PbO2 exhibited a high attenuation coefficient (0.284 cm−1) and were stretched to 400% without a rupture. Furthermore, the fabricated soft shield can be sewn without a fabric support due to its high energy-dispersion ability. A wearable arm shield for the γ-ray radiation was demonstrated using a direct sewing of the soft-shield materials.
VLA radio observations of AR Scorpii
Authors: Stanway E. R. , Marsh T. R. , Chote P. , Gänsicke B. T. , Steeghs D. , Wheatley P. J. 
Published: January 2018

Aims. AR Scorpii is unique amongst known white dwarf binaries in showing powerful pulsations extending to radio frequencies. Here we aim to investigate the multi-frequency radio emission of AR Sco in detail, in order to constrain its origin and emission mechanisms.
Methods. We present interferometric radio frequency imaging of AR Sco at 1.5, 5 and 9 GHz, analysing the total flux and polarization behaviour of this source at high time resolution (10, 3 and 3 s), across a full 3.6 h orbital period in each band.
Results. We find strong modulation of the radio flux on the orbital period and the orbital sideband of the white dwarf’s spin period (also known as the “beat” period). This indicates that, like the optical flux, the radio flux arises predominantly from on or near the inner surface of the M-dwarf companion star. The beat-phase pulsations of AR Sco decrease in strength with decreasing frequency. They are strongest at 9 GHz and at an orbital phase ~0.5. Unlike the optical emission from this source, radio emission from AR Sco shows weak linear polarization but very strong circular polarization, reaching ~30% at an orbital phase ~0.8. We infer the probable existence of a non-relativistic cyclotron emission component, which dominates at low radio frequencies. Given the required magnetic fields, this also likely arises from on or near the M-dwarf.
Demenzsensibles Krankenhaus
Authors: Blumenrode Stefan 
Published: January 2018

Zusammenfassung
Das Projekt HuBerTDA Die Einweisung in ein Krankenhaus stellt für Menschen mit Demenz eine besondere Belastung dar. Um diese Patienten
bedürfnisorientiert zu behandeln und sensibel auf ihre Belange einzugehen, wurde am Klinikum Stuttgart das Projekt „Handeln im Hier und
Jetzt! BereiT zum Demenz- und Alterssensiblen Krankenhaus“ – kurz HuBerTDA – entwickelt. Unser Autor hat den Projektverlauf begleitet.
Muscle Thickness and Passive Muscle Stiffness in Elite Athletes: Implications of the Effect of Long-Term Daily Training on Skeletal Muscle
Authors: Chino Kentaro , Ohya Toshiyuki , Kato Emika , Suzuki Yasuhiro 
Published: January 2018

AbstractTo examine the effect of long-term daily training on athletes’ skeletal muscle, this study determined the relation between their muscle thickness and passive muscle stiffness, and compared the muscle thickness and muscle stiffness between athletes and non-athletes. Participants were elite Japanese athletes (278 men, 200 women) from various sports and non-athletes (35 men, 35 women). Rectus femoris (RF) muscle thickness was measured using B-mode ultrasonography and was normalized to the total body mass (muscle thickness/body mass1/3). RF passive muscle stiffness (shear modulus) was assessed by ultrasound shear-wave elastography. There was a negligibly significant correlation between muscle thickness and muscle stiffness in male athletes (p=0.003; r=−0.18) but not in female athletes (p=0.764; r=0.02). Among men, muscle thickness was significantly greater in athletes than non-athletes (p<0.001), whereas muscle stiffness was significantly less in athletes than non-athletes (p=0.020). Among women, muscle thickness was significantly greater in athletes than non-athletes (p<0.001), whereas muscle stiffness did not differ significantly between athletes and non-athletes (p=0.412). These results suggest that the effect of long-term daily training performed by athletes on muscle stiffness is more complicated than that on muscle thickness.
Engineered bio-inspired coating for passive flow control
Authors: Bocanegra Evans Humberto , Hamed Ali M. , Gorumlu Serdar , Doosttalab Ali , Aksak Burak , Chamorro Leonardo P. , Castillo Luciano 
Published: January 2018

Significance
Flow separation on moving bodies has a negative effect on energy efficiency. Reducing recirculating regions is key in the design of energy-efficient systems. Efficient design decreases fuel consumption and pollutant emissions, including the systems’ carbon footprint. The engineered bio-inspired coating presented here aims to contribute in that direction. The relative ease of manufacturing and installation and its cost effectiveness, as well as its functionality under both wet and dry conditions, make it a versatile solution of potentially high impact in a broad range of applications, including transportation, wind power, and underwater vehicles.