bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classical hypercorrelation and wave-optics analogy of quantum superdense coding
Authors: Li Pengyun , Sun Yifan , Yang Zhenwei , Song Xinbing , Zhang Xiangdong 
Published: December 2015

AbstractWe report the first experimental realization of classical hypercorrelation, correlated simultaneously in every degree of freedom (DOF), from observing a Bell-type inequality violation in each DOF: polarization and orbital angular momentum (OAM). Based on such a classical hypercorrelation, we have realized the analogy of quantum superdense coding in classical optics. Comparing it with quantum superdense coding using pairs of photons simultaneously entangled in polarization and OAM, we find that it exhibits many advantages. It is not only very convenient to realize in classical optics, the attainable channel capacity in the experiment for such a superdense coding can also reach 3 bits, which is higher than that (2.8 bits) of usual quantum one. Our findings can not only give novel insight into quantum physics, they may also open a new field of applications in the classical optical information process.
Body part-centered and full body-centered peripersonal space representations
Authors: Serino Andrea , Noel Jean-Paul , Galli Giulia , Canzoneri Elisa , Marmaroli Patrick , Lissek Hervé , Blanke Olaf 
Published: December 2015

AbstractDedicated neural systems represent the space surrounding the body, termed Peripersonal space (PPS), by integrating visual or auditory stimuli occurring near the body with somatosensory information. As a behavioral proxy to PPS, we measured participants’ reaction time to tactile stimulation while task-irrelevant auditory or visual stimuli were presented at different distances from their body. In 7 experiments we delineated the critical distance at which auditory or visual stimuli boosted tactile processing on the hand, face and trunk as a proxy of the PPS extension. Three main findings were obtained. First, the size of PPS varied according to the stimulated body part, being progressively bigger for the hand, then face and largest for the trunk. Second, while approaching stimuli always modulated tactile processing in a space-dependent manner, receding stimuli did so only for the hand. Finally, the extension of PPS around the hand and the face varied according to their relative positioning and stimuli congruency, whereas the trunk PPS was constant. These results suggest that at least three body-part specific PPS representations exist, differing in extension and directional tuning. These distinct PPS representations, however, are not fully independent from each other, but referenced to the common reference frame of the trunk.
Wireless thin film transistor based on micro magnetic induction coupling antenna
Authors: Jun Byoung Ok , Lee Gwang Jun , Kang Jong Gu , Kim Seunguk , Choi Ji-Woong , Cha Seung Nam , Sohn Jung Inn , Jang Jae Eun 
Published: December 2015

AbstractA wireless thin film transistor (TFT) structure in which a source/drain or a gate is connected directly to a micro antenna to receive or transmit signals or power can be an important building block, acting as an electrical switch, a rectifier or an amplifier, for various electronics as well as microelectronics, since it allows simple connection with other devices, unlike conventional wire connections. An amorphous indium gallium zinc oxide (α-IGZO) TFT with magnetic antenna structure was fabricated and studied for this purpose. To enhance the induction coupling efficiency while maintaining the same small antenna size, a magnetic core structure consisting of Ni and nanowires was formed under the antenna. With the micro-antenna connected to a source/drain or a gate of the TFT, working electrical signals were well controlled. The results demonstrated the device as an alternative solution to existing wire connections which cause a number of problems in various fields such as flexible/wearable devices, body implanted devices, micro/nano robots and sensors for the ‘internet of things’ (IoT).
Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1
Authors: Jiang Shinn-Jong , Liou Je-Wen , Chang Chun-Chun , Chung Yi , Lin Lee-Fong , Hsu Hao-Jen 
Published: December 2015

AbstractChemokine CXCL8 is crucial for regulation of inflammatory and immune responses via activating its cognate receptor CXCR1. In this study, molecular docking and binding free energy calculations were combined to predict the initial binding event of CXCL8 to CXCR1 for peptide drug design. The simulations reveal that in the initial binding, the N-loop of CXCL8 interacts with the N-terminus of CXCR1, which is dominated by electrostatic interactions. The derived peptides from the binding region of CXCL8 are synthesized for further confirmation. Surface plasmon resonance analyses indicate that the CXCL8 derived peptide with 14 residues is able to bind to the receptor CXCR1 derived peptide with equilibrium KD of 252 μM while the peptide encompassing a CXCL8 K15A mutation hardly binds to CXCR1 derived peptide (KD = 1553 μM). The cell experiments show that the designed peptide inhibits CXCL8-induced and LPS-activated monocytes adhesion and transmigration. However, when the peptides were mutated on two lysine residues (K15 and K20), the inhibition effects were greatly reduced indicating these two amino acids are key residues for the initial binding of CXCL8 to CXCR1. This study demonstrates that in silico prediction based functional peptide design can be effective for developing anti-inflammation drugs.
Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer
Authors: Li Yanshuang , Zhao Lianmei , Shi Bianhua , Ma Sisi , Xu Zhenbiao , Ge Yehua , Liu Yanxin , Zheng Dexian , Shi Juan 
Published: December 2015

AbstractTumor-associated macrophages (TAMs) play critical roles in promoting tumor progression and invasion. However, the molecular mechanisms underlying TAM regulation remain to be further investigated and may make significant contributions to cancer treatment. Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression that function by repressing specific target genes mainly at the post-transcriptional level. However, systematic studies of the functions and mechanisms of miRNAs in TAMs in tumor tissues are rare. In this study, miR-146a and miR-222 were shown to be significantly decreased in TAMs associated with the up-regulated NF-κB p50 subunit. miR-146a promoted the expression of some M2 macrophage phenotype molecules and miR-146a antagomir transfected RAW264.7 monocyte-macrophage cells inhibited 4T1 tumor growth in vivo. Meanwhile, overexpression of miR-222 inhibited TAM chemotaxis and miR-222 in TAMs inhibited 4T1 tumor growth by targeting CXCL12 and inhibiting CXCR4. These data revealed that miRNAs influence breast tumor growth by promoting the M2 type polarization or regulating the recruitment of TAMs. These observations suggest that endogenous miRNAs may exert an important role in controlling the polarization and function of TAMs in breast cancer.
Dynamical transition of heat transport in a physical gel near the sol-gel transition
Authors: Kobayashi Kazuya U. , Oikawa Noriko , Kurita Rei 
Published: December 2015

AbstractWe experimentally study heat transport in a gelatin solution near a reversible sol-gel transition point where viscosity strongly depends on temperature. We visualize the temperature field and velocity field using thermochromic liquid crystals and polystyrene latex particles, respectively. During the initial stages of heating, we find that heat transport undergoes a dynamical transition from conductive to convective. Subsequently, during later stages, we observe that the transport dynamics are much more complex than conventional thermal convections. At the sample’s surface we observe the formation of stagnant domains, which lack fluid flow. Their formation is not due to the effects of local cooling. We determine that it is the dynamics of these stagnant domains that induce convective-conductive-convective transitions.
Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats
Authors: Keune Jessica A. , Branscum Adam J. , Iwaniec Urszula T. , Turner Russell T. 
Published: December 2015

AbstractThis study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing (2ndlumbar vertebra and calvarium) bones in the context of ovarian hormone insufficiency. 12-week-old Fisher 344 rats were ovariectomized 2 weeks before flight and randomized into one of three groups: 1) baseline (n = 6), 2) ground control (n = 12) or 3) spaceflight (n = 12). Additional ground-based ovary-intact rats provided age-matched reference values at baseline (n = 8) and landing (n = 10). Ovariectomy resulted in bone- and bone compartment-specific deficits in cancellous bone volume fraction. Spaceflight resulted in lower cortical bone accrual in the femur but had no effect on cortical bone in the humerus or calvarium. Cancellous bone volume fraction was lower in flight animals compared to ground control animals in lumbar vertebra and distal femur metaphysis and epiphysis; significant differences were not detected in the distal humerus. Bone loss (compared to baseline controls) in the femur metaphysis was associated with lower trabecular number, whereas trabecular thickness and number were lower in the epiphysis. In summary, the effect of spaceflight on bone microarchitecture in ovariectomized rats was bone-and bone compartment-specific but not strictly related to weight bearing.
Parallel Analysis of 124 Universal SNPs for Human Identification by Targeted Semiconductor Sequencing
Authors: Zhang Suhua , Bian Yingnan , Zhang Zheren , Zheng Hancheng , Wang Zheng , Zha Lagabaiyila , Cai Jifeng , Gao Yuzhen , Ji Chaoneng , Hou Yiping , Li Chengtao 
Published: December 2015

AbstractSNPs, abundant in human genome with lower mutation rate, are attractive to genetic application like forensic, anthropological and evolutionary studies. Universal SNPs showing little allelic frequency variation among populations while remaining highly informative for human identification were obtained from previous studies. However, genotyping tools target only dozens of markers simultaneously, limiting their applications. Here, 124 SNPs were simultaneous tested using Ampliseq technology with Ion Torrent PGM platform. Concordance study was performed with 2 reference samples of 9947A and 9948 between NGS and Sanger sequencing. Full concordance were obtained except genotype of rs576261 with 9947A. Parameter of FMAR (%) was introduced for NGS data analysis for the first time, evaluating allelic performance, sensitivity testing and mixture testing. FMAR values for accurate heterozygotes should be range from 50% to 60%, for homozygotes or Y-SNP should be above 90%. SNPs of rs7520386, rs4530059, rs214955, rs1523537, rs2342747, rs576261 and rs12997453 were recognized as poorly performing loci, either with allelic imbalance or with lower coverage. Sensitivity testing demonstrated that with DNA range from 10 ng-0.5 ng, all correct genotypes were obtained. For mixture testing, a clear linear correlation (R2 = 0.9429) between the excepted FMAR and observed FMAR values of mixtures was observed.
Characterization of marine diatom-infecting virus promoters in the model diatom Phaeodactylum tricornutum
Authors: Kadono Takashi , Miyagawa-Yamaguchi Arisa , Kira Nozomu , Tomaru Yuji , Okami Takuma , Yoshimatsu Takamichi , Hou Liyuan , Ohama Takeshi , Fukunaga Kazunari , Okauchi Masanori , Yamaguchi Haruo , Ohnishi Kohei , Falciatore Angela , Adachi Masao 
Published: December 2015

AbstractViruses are considered key players in phytoplankton population control in oceans. However, mechanisms that control viral gene expression in prominent microalgae such as diatoms remain largely unknown. In this study, potential promoter regions isolated from several marine diatom-infecting viruses (DIVs) were linked to the egfp reporter gene and transformed into the Pennales diatom Phaeodactylum tricornutum. We analysed their activity in cells grown under different conditions. Compared to diatom endogenous promoters, novel DIV promoter (ClP1) mediated a significantly higher degree of reporter transcription and translation. Stable expression levels were observed in transformants grown under both light and dark conditions and high levels of expression were reported in cells in the stationary phase compared to the exponential phase of growth. Conserved motifs in the sequence of DIV promoters were also found. These results allow the identification of novel regulatory regions that drive DIV gene expression and further examinations of the mechanisms that control virus-mediated bloom control in diatoms. Moreover, the identified ClP1 promoter can serve as a novel tool for metabolic engineering of diatoms. This is the first report describing a promoter of DIVs that may be of use in basic and applied diatom research.
Evaluation of Community-Level Physiological Profiling for Monitoring Microbial Community Function in Aquaculture Ponds
Authors: Kurten Gerald L , Barkoh Aaron 
Published: December 2015

Abstract
Microbial communities in aquaculture ponds play pivotal roles in pond productivity and fish production success. Nonetheless, culturists do not consider this variable in pond management decision making likely because of a lack of practical assessment tools. Therefore, we evaluated the community-level physiological profiling (CLPP) technique for characterizing microbial community function for use in aquaculture. Unfiltered water samples collected from various plastic-lined ponds over time were incubated on Biolog EcoPlates. Responses (substrate optical densities) were measured at 24-h intervals for up to 12 d to determine the best incubation interval and the number of required replicates needed for determining microbial community function in aquaculture ponds. The repeatability and within-pond variability of the CLPP metrics were also evaluated. During cooler months and in ponds with no fish and low apparent microbial activity, a 96-h incubation period was required to differentiate microbial community functional characteristics. During warmer months and when ponds were stocked with fish and had significant phytoplankton blooms, incubation periods of 72 h were sufficient. For routine monitoring, a single sample of pond water on one Biolog EcoPlate was adequate for assessing microbial community function. Multiple water samples from a single pond revealed low heterogeneity in the microbial community function. When multiple Biolog EcoPlates were inoculated with a single sample of pond water the dissimilarity of substrate responses was low (2.9%), indicating high repeatability of the CLPP technique. The CLPP method appears to be robust and allows for the assessment of functional characteristics of the heterotrophic microbial community such as relative diversity, similarity, and community functional activity. Therefore, this technique may be used by fish culturists to assess hatchery pond microbial community function, which would lead to a better understanding of the importance of the microbial community to the overall aquaculture pond ecosystem function. Such a tool would allow improved and more comprehensive management of aquaculture pond ecosystems.
Effect of repeat‐sprint training in hypoxia on post‐exercise interleukin‐6 and F2‐isoprostanes
Authors: Goods Paul S. R. , Dawson Brian , Landers Grant J. , Gore Christopher J. , Croft Kevin , Peeling Peter 
Published: December 2015

AbstractThis investigation examined the oxidative stress (F2‐Isoprostane; F2‐IsoP) and inflammatory (interleukin‐6; IL‐6) responses to repeat‐sprint training in hypoxia (RSH). Ten trained male team sport athletes performed 3(sets)*9(repetitions)*5 s cycling sprints in simulated altitude (3000 m) and sea‐level conditions. Mean and peak sprint power output (MPO and PPO) were recorded, and blood samples were collected pre‐exercise, and again at 8 and 60 min post‐exercise. Both MPO and PPO were significantly reduced in hypoxia (compared to sea‐level) in the second (MPO: 855 ± 89 vs. 739 ± 95 W, p = .006; PPO: 1024 ± 114 vs. 895 ± 112 W, p = .010) and third (MPO: 819 ± 105 vs. 686 ± 83 W, p = .008; PPO: 985 ± 125 vs. 834 ± 99 W, p = .008) sets, respectively. IL‐6 was significantly increased from pre‐ to 1 h post‐exercise in both hypoxia (0.7 ± 0.2 vs. 2.4 ± 1.4 pg/mL, p = .004) and sea‐level conditions (0.7 ± 0.2 vs. 1.6 ± 0.3 pg/mL, p < .001), with a large effect (d = 0.80) suggesting higher IL‐6 levels of post‐hypoxia. F2‐IsoP was significantly lower 1 h post‐exercise in both the hypoxic (p = .005) and sea‐level (p = .002) conditions, with no differences between trials. While hypoxia can impact on exercise intensity and may result in greater post‐exercise inflammation, it appears to have little effect on oxidative stress. These results indicate that team sport organisations with ready access to hypoxic training facilities could confidently administer RSH without significantly increasing the post‐exercise inflammatory or oxidative stress response.
The disastrous consequences of the Ikea Effect: Apple, Intel and Wang Labs learning the cost of true love
Authors: Thomas Mark , Alluru Jayanth-Reddy 
Published: December 2015

Purpose
– This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies.

Design/methodology/approach
– This briefing is prepared by independent writers who add their own impartial comments and place the articles in context.

Findings
– Falling in love with one’s own product is not rational behavior and could be misleading, as it blinds people to strategic foresight. Products should be designed with a strategic focus that is both innovation- and customer-centric.

Practical implications
– The paper provides strategic insights and practical thinking that have influenced some of the world’s leading organizations.

Originality/value
– The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.
Epilogue—from ‘Gray Space' to Equal ‘Metrozenship'? Reflections On Urban Citizenship
Authors: Yiftachel Oren 
Published: December 2015

AbstractThis epilogue provides an overview and critique of the articles in this symposium, and an invitation to rethink, conceptually and empirically, our urban future. Using examples from cities in Israel/Palestine, it links the articles to the main currents in the literature on urban citizenship and ‘right to the city'. It draws attention to several voids in current debates, particularly around the rapid growth of urban informality and the changing nature of globalizing urban regimes. The epilogue introduces the notions of ‘gray spacing' to account for recent transformations in these regimes and the rise of ‘defensive urban citizenship' under conditions of neoliberal economy and persisting nationalism. It argues for the rethinking of the struggle for urban democracy in terms of ‘metrozenship' as a foundation for renewed critical research and political transformation.
Preference Heterogeneity in Contingent Behaviour Travel Cost Models with On‐site Samples: A Random Parameter vs. a Latent Class Approach
Authors: Hynes Stephen , Greene William 
Published: December 2015

AbstractIn this paper, we examine heterogeneity in the trip preferences of recreationists. We apply a random parameters negative binomial model and a latent class negative binomial model to a panel dataset of beach users at a site on the west coast of Ireland, where access across farmland has been restricted. This approach allows us to account for heterogeneity with respect to the impact of the chosen explanatory variables in a contingent behaviour travel cost model of demand where the researcher must also account for the fact that the sample data has been collected on‐site. The analysis also develops individual consumer surplus estimates and finds that estimates are systematically affected by both the random parameter and latent class specifications. There is also evidence that accounting for individual heterogeneity improves the statistical fit of the models and provides a more informative description of the drivers of recreationalist trip behaviour.
Age Estimation in Living Adults using 3D Volume Rendered CT Images of the Sternal Plastron and Lower Chest
Authors: Oldrini Guillaume , Harter Valentin , Witte Yannick , Martrille Laurent , Blum Alain 
Published: December 2015

AbstractAge estimation is commonly of interest in a judicial context. In adults, it is less documented than in children. The aim of this study was to evaluate age estimation in adults usingCTimages of the sternal plastron with volume rendering technique (VRT). The evaluation criteria are derived from known methods used for age estimation and are applicable in living or dead subjects. TheVRTimages of 456 patients were analyzed. Two radiologists performed age estimation independently from an anterior view of the plastron. Interobserver agreement and correlation coefficients between each reader's classification and real age were calculated. The interobserver agreement was 0.86, and the correlation coefficients between readers classifications and real age classes were 0.60 and 0.65. Spearman correlation coefficients were, respectively, 0.89, 0.67, and 0.71. Analysis of the plastron usingVRTallows age estimationin vivoquickly and with results similar than methods such as Iscan, Suchey–Brooks, and radiographs used to estimate the age of death.
Decisional Capacity to Consent to Clinical Research Involving Placebo in Psychiatric Patients
Authors: Parmigiani Giovanna , Mandarelli Gabriele , Dacquino Claudia , Pompili Pieritalo , Lelli Chiesa Giovanni , Ferracuti Stefano 
Published: December 2015

AbstractEvidence from a few studies indicates the existence of several issues related to psychiatric patients' decisional capacity to give informed consent to clinical research. Clinicians often face difficulties in acquiring valid informed consent in clinical practice and even more so in drug trials. Participants often fail to fully understand or retain information regarding the actual implications of research protocols. The Brief Assessment for Consent to Clinical Research (BACO) was developed to investigate capacity to consent to clinical trials and further compare patients with schizophrenia and healthy comparisons' decisional capacity. A method to avoid possible confounding effects of choosing a treatment regarding a current disease was applied. The study groups were administered the BACO and the MacArthur Competence Assessment Tool for Clinical Research. Psychiatric patients performed poorer in comprehending, appreciating, and reasoning abilities, than their healthy counterparts. Impaired cognitive functioning and psychiatric symptoms severity were associated with reduced capacity to consent.
Enchanted and Disenchanted International Law
Authors: Hurd Ian 
Published: December 2015

AbstractScholars and activists commonly see international law in a privileged normative and political position in world politics, where international legal institutions are assumed to advance important goals such as international stability, human justice and even global order as a whole. I explore this attitude toward international law, which I call an ‘enchanted’ view, and contrast it to the ‘disenchanted’ alternative. Where the enchanted attitude presumes the normative valence and political wisdom of following international law, the disenchanted approach treats these as open questions for inquiry and discussion. The disenchanted approach is more empirically minded, and more politically open, than the enchanted, and leads to a distinct research program on legalization in international affairs – one that is attentive to the politics of law, the connections between law and power, the ambiguity that exists between legality and policy wisdom.