bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Markers of Reperfusion in Patients with Acute Myocardial Infarction and Its Prognostic Significance
Authors: Varma Anuj , Chillawar Swapnil , Kamble T , Acharya Sourya 
Published: December 2016

Abstract
Introduction: Coronary artery disease (CAD) is a major cause of mortality worldwide. Thrombolysis in the treatment of acute myocardial infarction (AMI) is a landmark event in the management as it has changed the outcomes. Clinical signs after thrombolysis in AMI may have a better correlation with functional reperfusion than the isolated image of angiographic patency.
Aims and objectives: To study successful clinical reperfusion (SCR) noninvasively using clinical markers of reperfusion. To evaluate the prognostic value of clinical markers of reperfusion in predicting early (30 days) prognosis after thrombolysis in AMI. To observe the effect of age, location of MI, presence of previous infarction, Killip's class at admission, and presence of clinical reperfusion assessed noninvasively on early (30 days) prognosis after AMI.
Materials and methods: All the patients were thrombolyzed (using streptokinase). Successful clinical reperfusion was defined by the presence of at least two of the following criteria at 2 hours of starting treatment: (1) Significant relief of pain (50% or more), (2) 50% or more reduction in sum of ST segment elevation, (3) abrupt initial rise of creatine kinase MB (CK-MB) level, more than two-fold over upper normal or baseline values.
Results: Duration of symptoms (min) mean ± SD was nearly the same in two groups (94.80 ± 13.68 vs 96.19 ± 17) but early thrombolysis resulted in better outcome (0.01 S, p < 0.05). killips class at admission (KAD) > OR = 2, n (%) led to worsened fate of thrombolysis. Death n (%) occurred in 7 (8.75%) patients with 1 (1.25%) from SCR (+) group and 6 (7.5%) from SCR (–) group (0.01 S, p < 0.05).
Conclusion: It is concluded that Killip's class at admission of more than or equal to two and absence of SCR are the predictors of mortality after thrombolysis. Absence of SCR defines a group of patients with poorer prognosis after thrombolysis and in such patients alternative strategies of reperfusion should be considered.
Mandibular Bone Mineral Density to predict Skeletal Osteoporosis: A Literature Review
Authors: Pisulkar Sweta , Pisulkar Gajanan , Pakhan Ashok , Godbole Surekha , Dahane Trupti 
Published: December 2016

AbstractUntil and unless the disease is recognized as a disease entity, a little progress has been made in understanding its etiology and in developing a predictable treatment planning, restoration, and prevention of the tissues. In a process carried out to study a disease entity, whether it be cardiac disease, dental caries, or periodontal disease, it is helpful to study its pathology (the gross and microscopic structural changes of the disease), its pathophysiology (the mechanisms or disordered functions of the disease), its pathogenesis (the life history), and its epidemiology (the worldwide prevalence of the disease and various interrelated factors). The ultimate aim of such researches is the better understanding of the etiology and pathogenesis of the disease, and thereby with such understanding leading to a predictable treatment planning and ultimately the prevention or control of these factors. Osteoporosis is a major health entity affecting the elderly population and thereby resulting in approximately 1.3 million spontaneous fractures in the USA every year. The above clinical condition is a deficiency of bone mass, or skeletal osteopenia, to that level where bone cannot provide adequate mechanical support. Many of the reported studies used inadequate measures of both skeletal and mandibular bone in evaluating their possible relationships. This literature review attempts to determine relationships between the total skeletal bone mass and bone mass of the mandible in the population suffering with osteoporosis.
Accentuated Skin Markings: A Clinical Clue for Idiopathic Eruptive Macular Pigmentation
Authors: Khare Stuti , Madke Bhushan , Singh Adarshlata 
Published: December 2016

AbstractIdiopathic eruptive macular pigmentation (IEMP) is a distinct clinicopathologic entity of which less cases have been reported in the literature. We report here a case of a 16-year-old boy who had completely asymptomatic brownish-colored lesions distributed over the trunk, back, and upper limbs since 4 months, and histopathologic findings showed features consistent with diagnosis of IEMP with one additional finding having papillomatosis with moderate acanthosis. We are reporting this case with additional clinical finding that is accentuated skin markings similar to acanthosis on dermoscopy, which aid in clinical diagnosis of this less reported entity. This helps avoidance of unnecessary treatment for this self-resolving state.
Fostering Full Implementation of Evidence-Based Practice
Authors: Marr Deborah 
Published: December 2016

Abstract
Evidence-based practice (EBP) is a widely endorsed concept, but many occupational therapy practitioners would like to be more informed and supported in its full implementation. They need information on the evolving definitions and concepts of EBP, encouragement to develop and adopt EBP models that link to occupational therapy’s professional values, and methods that translate evidence into answers for clinical questions. This column discusses these needs and makes recommendations to the American Occupational Therapy Association for addressing them.
Reviewer Acknowledgements for Vol. 4, No. 4, December 2016
Authors: Williams Richard 
Published: December 2016

Reviewer Acknowledgements for Vol. 4, No. 4, December 2016Journal of Agricultural Studies would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JAS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issueReviewers for Volume 4, Number 4 Abhishek A. CukkemaneAftab AlamAriel Reinaldo SotoChenlin HuEwa MoliszewskaGerardo OjedaJeong HwanSahar BahmaniZakaria Fouad Abdallah Zhao Chen Richard WilliamsEditorJournal of Agricultural Studies-------------------------------------------Macrothink Institute5348 Vegas Dr.#825Las Vegas, Nevada 89108United StatesPhone: 1-702-953-1852 ext.521Fax: 1-702-420-2900Email: jas@macrothink.orgURL: http://jas.macrothink.org
Hoe staat de lokale democratie in Nederland ervoor?
Authors: Peters Klaartje , van Stipdonk Vincent 
Published: December 2016

What is the state of local democracy in the Netherlands?
Is local democracy in the Netherlands equipped for its mission? There is confusion and disagreement about the answer to this question. How people assess existing democratic practices is strongly influenced by one of the three main perspectives: representative democracy, participative (deliberative) democracy or ‘do-democracy’ (associative democracy). But to be able to have this discussion in the first place, empirical knowledge is required about the state of democracy at the local level. In this article (apart from the introduction, the first in a series on the local democratic audit) the authors bring together the available research data and organize these data with the help of David Easton’s system model: from input of citizens and civil society via throughput to output and finally feedback again in the political system. The research presented offers some insight in the state of local democracy, although it is not possible to give a final assessment. That depends on the perspective on democracy chosen, but it is also not possible because of the fragmented and incomplete nature of the research on local democracy in the Netherlands. The authors advocate contributing to these discussions with more empirical knowledge. The overview in this article shows that there is work to be done in this respect.
Molecular and Quantum Mechanical Study for the Separation of Cefprozil in the Presence of Its Alkaline Degradation Product Using RP-HPLC with UV Detection
Authors: Attia Khalid A M , Nassar Mohammed W I , El-Zeiny Mohamed B , Serag Ahmed 
Published: December 2016

Abstract
A reversed-phase HPLC method (RP-HPLC) with UV detection was developed and validated for the quantitative determination of cefprozil, a second-generation cephalosporin. Due to β-lactam ring instability under alkaline conditions, this RP-HPLC method was applied for the determination of cefprozil in the presence of its possible degradation product. The interactions that govern the separation process with stationary phase were investigated at both molecular and quantum mechanical levels. Moreover, electrostatic potential maps were generated to determine the sites of interaction with mobile phase. The suggested method was validated in compliance with International Conference on Harmonization guidelines and successfully applied for the determination of cefprozil in its commercial pharmaceutical formulation.
Interannual variability in ozone removal by a temperate deciduous forest
Authors: Clifton O. E. , Fiore A. M. , Munger J. W. , Malyshev S. , Horowitz L. W. , Shevliakova E. , Paulot F. , Murray L. T. , Griffin K. L. 
Published: December 2016

AbstractThe ozone (O3) dry depositional sink and its contribution to observed variability in tropospheric O3 are both poorly understood. Distinguishing O3 uptake through plant stomata versus other pathways is relevant for quantifying the O3 influence on carbon and water cycles. We use a decade of O3, carbon, and energy eddy covariance (EC) fluxes at Harvard Forest to investigate interannual variability (IAV) in O3 deposition velocities (
). In each month, monthly mean
for the highest year is twice that for the lowest. Two independent stomatal conductance estimates, based on either water vapor EC or gross primary productivity, vary little from year to year relative to canopy conductance. We conclude that nonstomatal deposition controls the substantial observed IAV in summertime
during the 1990s over this deciduous forest. The absence of obvious relationships between meteorology and
implies a need for additional long‐term, high‐quality measurements and further investigation of nonstomatal mechanisms.
Satellite sea surface temperatures along the West Coast of the United States during the 2014–2016 northeast Pacific marine heat wave
Authors: Gentemann Chelle L. , Fewings Melanie R. , García‐Reyes Marisol 
Published: December 2016

AbstractFrom January 2014 to August 2016, sea surface temperatures (SSTs) along the Washington, Oregon, and California coasts were significantly warmer than usual, reaching a maximum SST anomaly of 6.2°C off Southern California. This marine heat wave occurred alongside the Gulf of Alaska marine heat wave and resulted in major disturbances in the California Current ecosystem and massive economic impacts. Here we use satellite and blended reanalysis products to report the magnitude, extent, duration, and evolution of SSTs and wind stress anomalies along the West Coast of the continental United States during this event. Nearshore SST anomalies along the entire coast were persistent during the marine heat wave, and only abated seasonally, during spring upwelling‐favorable wind stress. The coastal marine heat wave weakened in July 2016 and disappeared by September 2016.
Increase in the number of extremely strong fronts over Europe? A study based on ERA‐Interim reanalysis (1979–2014)
Authors: Schemm S. , Sprenger M. , Martius O. , Wernli H. , Zimmer M. 
Published: December 2016

AbstractEvidence is presented that the frequency of extremely strong fronts, which occur mainly in summer, has increased over Europe in ERA‐Interim reanalyses data (1979–2014). Fronts are defined using a common detection scheme based on gradients of equivalent potential temperature (θe) at 850 hPa. The frequency increase is due to increasing atmospheric humidity, which in turn is reported as statistically significant over Europe in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC AR5). There is no trend in the frequency of extremely strong fronts in North America where humidity trends are, according to the IPCC AR5, close to zero. Because frontal precipitation increases with frontal strength, measured by the θe gradient, the increase in the number of extremely strong fronts may help explain regional patterns of longer‐term trends in strong precipitation events.
Tomographic reconstruction of an aerosol plume using passive multiangle observations from the MISR satellite instrument
Authors: Garay Michael J. , Davis Anthony B. , Diner David J. 
Published: December 2016

AbstractWe present initial results using computed tomography to reconstruct the three‐dimensional structure of an aerosol plume from passive observations made by the Multi‐angle Imaging SpectroRadiometer (MISR) instrument on NASA's Terra satellite. MISR views the Earth from nine different angles at four visible and near‐infrared wavelengths. Adopting the 672 nm channel, we treat each view as an independent measure of aerosol optical thickness along the line of sight at 1.1 km resolution. A smoke plume over dark water is selected as it provides a more tractable lower boundary condition for the retrieval. A tomographic algorithm is used to reconstruct the horizontal and vertical aerosol extinction field for one along‐track slice from the path of all camera rays passing through a regular grid. The results compare well with ground‐based lidar observations from a nearby Micropulse Lidar Network site.
Double‐counting challenges the accuracy of high‐latitude methane inventories
Authors: Thornton Brett F. , Wik Martin , Crill Patrick M. 
Published: December 2016

AbstractQuantification of the present and future contribution to atmospheric methane (CH4) from lakes, wetlands, fluvial systems, and, potentially, coastal waters remains an important unfinished task for balancing the global CH4 budget. Discriminating between these sources is crucial, especially across climate‐sensitive Arctic and subarctic landscapes and waters. Yet basic underlying uncertainties remain, in such areas as total wetland area and definitions of wetlands, which can lead to conflation of wetlands and small ponds in regional studies. We discuss how in situ sampling choices, remote sensing limitations, and isotopic signature overlaps can lead to unintentional double‐counting of CH4 emissions and propose that this double‐counting can explain a pan‐Arctic bottom‐up estimate from published sources, 59.7 Tg yr−1 (range 36.9–89.4 Tg yr−1) greatly exceeding the most recent top‐down inverse modeled estimate of the pan‐Arctic CH4 budget (23 ± 5 Tg yr−1).
A Multicomponent Strategy for the Regioselective Synthesis of [1,3]‐Thiazinones from an Abundant Feedstock: Scope and Structural Elucidation
Authors: Wadhwa Preeti , Shube Hussen Abdulkadir , Sharma Anuj 
Published: December 2016

AbstractA novel and regioselective protocol for the synthesis of [1,3]‐thiazinones via multicomponent reactions of readily available isothiocyanates, hydrazine monohydrate, aldehydes and dialkyl acetylenedicarboxylates is described. This approach exhibits operational simplicity, offering a new and expedient strategy for the direct synthesis of synthetically useful [1,3]‐thiazinone compounds in good to excellent yields. The method could provide a low‐cost and environmentally benign alternative to currently employed methods. Moreover, unambiguous determination of the single product regioisomer through detailed 2D NMR spectroscopy, the scope and limitations of this environmentally friendly domino reaction are discussed.
Versatile Trityl Spin Labels for Nanometer Distance Measurements on Biomolecules In Vitro and within Cells
Authors: Jassoy J. Jacques , Berndhäuser Andreas , Duthie Fraser , Kühn Sebastian P. , Hagelueken Gregor , Schiemann Olav 
Published: December 2016

AbstractStructure determination of biomacromolecules under in‐cell conditions is a relevant yet challenging task. Electron paramagnetic resonance (EPR) distance measurements in combination with site‐directed spin labeling (SDSL) are a valuable tool in this endeavor but the usually used nitroxide spin labels are not well‐suited for in‐cell measurements. In contrast, triarylmethyl (trityl) radicals are highly persistent, exhibit a long relaxation time and a narrow spectral width. Here, the synthesis of a versatile collection of trityl spin labels and their application in in vitro and in‐cell trityl–iron distance measurements on a cytochrome P450 protein are described. The trityl labels show similar labeling efficiencies and better signal‐to‐noise ratios (SNR) as compared to the popular methanethiosulfonate spin label (MTSSL) and enabled a successful in‐cell measurement.
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
Authors: Wiedmann Mareike M. , Tan Yaw Sing , Wu Yuteng , Aibara Shintaro , Xu Wenshu , Sore Hannah F. , Verma Chandra S. , Itzhaki Laura , Stewart Murray , Brenton James D. , Spring David R. 
Published: December 2016

AbstractThere is a lack of current treatment options for ovarian clear cell carcinoma (CCC) and the cancer is often resistant to platinum‐based chemotherapy. Hence there is an urgent need for novel therapeutics. The transcription factor hepatocyte nuclear factor 1β (HNF1β) is ubiquitously overexpressed in CCC and is seen as an attractive therapeutic target. This was validated through shRNA‐mediated knockdown of the target protein, HNF1β, in five high‐ and low‐HNF1β‐expressing CCC lines. To inhibit the protein function, cell‐permeable, non‐helical constrained proteomimetics to target the HNF1β–importin α protein–protein interaction were designed, guided by X‐ray crystallographic data and molecular dynamics simulations. In this way, we developed the first reported series of constrained peptide nuclear import inhibitors. Importantly, this general approach may be extended to other transcription factors.
A Redox‐Induced Spin‐State Cascade in a Mixed‐Valent Fe3(μ3‐O) Triangle
Authors: Govor Evgen V. , Al‐Ameed Karrar , Chakraborty Indranil , Coste Carla S. , Govor Olena , Sanakis Yiannis , McGrady John E. , Raptis Raphael G. 
Published: December 2016

AbstractOne‐electron reduction of a pyrazolate‐bridged triangular Fe3(μ3‐O) core induces a cascade wherein all three metal centers switch from high‐spin Fe3+ to low‐spin Fe2.66+. This hypothesis is supported by spectroscopic data (1H‐NMR, UV‐vis‐NIR, infra‐red, 57Fe‐Mössbauer, EPR), X‐ray crystallographic characterization of the cluster in both oxidation states and also density functional theory. The reduction induces substantial contraction in all bond lengths around the metal centers, along with diagnostic shifts in the spectroscopic parameters. This is, to the best of our knowledge, the first example of a one‐electron redox event causing concerted change in multiple iron centers.
Nickel‐Catalyzed CO2 Rearrangement of Enol Metal Carbonates for the Efficient Synthesis of β‐Ketocarboxylic Acids
Authors: Ninokata Ryo , Yamahira Tatsuya , Onodera Gen , Kimura Masanari 
Published: December 2016

Abstract4‐Methylene‐1,3‐dioxolan‐2‐ones underwent oxidative addition of a Ni0 catalyst in the presence of Me2Al(OMe), followed by a coupling reaction with alkynes, to form δ,ϵ‐unsaturated β‐ketocarboxylic acids with high regio‐ and stereoselectivity. The reaction proceeds by [1,3] rearrangement of an enol metal carbonate intermediate and the formal reinsertion of CO2.
Small Molecule Microarray Based Discovery of PARP14 Inhibitors
Authors: Peng Bo , Thorsell Ann‐Gerd , Karlberg Tobias , Schüler Herwig , Yao Shao Q. 
Published: December 2016

AbstractPoly(ADP‐ribose) polymerases (PARPs) are key enzymes in a variety of cellular processes. Most small‐molecule PARP inhibitors developed to date have been against PARP1, and suffer from poor selectivity. PARP14 has recently emerged as a potential therapeutic target, but its inhibitor development has trailed behind. Herein, we describe a small molecule microarray‐based strategy for high‐throughput synthesis, screening of >1000 potential bidentate inhibitors of PARPs, and the successful discovery of a potent PARP14 inhibitor H10 with >20‐fold selectivity over PARP1. Co‐crystallization of the PARP14/H10 complex indicated H10 bound to both the nicotinamide and the adenine subsites. Further structure–activity relationship studies identified important binding elements in the adenine subsite. In tumor cells, H10 was able to chemically knockdown endogenous PARP14 activities.
Improved gas selectivity of polyetherimide membrane by the incorporation of PIM polyimide phase
Authors: García María G. , Marchese José , Ochoa Nelio A. 
Published: December 2016

ABSTRACTThe aim of this work was to prepare blend membranes of a polyetherimide (PEI) and different ratios of a microporous polyimide (PIM‐B) in order to obtain an improved material for gas selectivity. Miscibility of the membranes was studied through fourier transform infrared spectroscopy (FTIR), Fluorescence, ultraviolet‐visible spectroscopy (UV–vis), polarize light microscope images, X‐ray diffraction (XRD), and differential scanning calorimetry analysis. Gas permeability assays were also performed. Results showed blends were partially miscible along the different ratios due to the existence of: (i) absorption shoulders at lower wavenumbers on the carbonyl stretching band; (ii) red‐shifting of Fluorescence and UV–vis absorption bands; (iii) decreasing of d‐spacing as the amount of PIM‐B phase increased; and (iv) composition‐dependent glass transition temperatures (Tgs). The mobility selectivity (Di/j) dominated H2 and O2 gas separations. High solubility coefficients (S) linked to PIM‐B microporosity improved the ideal gas selectivity of the blend membranes. PEI/PIM‐B membrane at the ratio of 80/20 showed impressive H2/CO2 (8.66) and O2/N2 (10.90) gas separation factors. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44682.
Sol–gel preparation of ultralow refractive index silica coatings with hydroxypropyl‐beta‐cyclodextrin as porogen
Authors: Yang Bowen , Luo Jianhui , Xia Bibo , Li Yuanyang , Zhang Shuming , jiang Bo 
Published: December 2016

ABSTRACTUltralow refractive index films were prepared based on a base‐catalyzed sol–gel process using methyltriethoxysilane (MTES), tetraethylorthosilicate (TEOS) as co‐precursors, and hydroxypropyl‐beta‐cyclodextrin (HPCD) as porogen. After further modification by hexamethylisilazane (HMDS), the lowest refractive index of these silica coatings obtained from the hybrid sol was 1.05 and the static water contact angles of the coatings increased from 66.4° to 128.7°. The effect of weight ratio of HPCD to SiO2 on the refractive index and on the formation of coating films were systematically studied. The data showed that the films prepared with HPCD as porogen got a pore diameter around 4 nm. Compared with those templates such as poloxamer (F127), HPCD not only perform well in decreasing the refractive index of films, but also eliminate light scattering caused by mesopore of the film, will have potential value in the field of surfactant‐templated methods. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44686.