bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central venous pressure monitoring via peripherally or centrally inserted central catheters: a systematic review and meta-analysis
Authors: Sanfilippo Filippo , Noto Alberto , Martucci Gennaro , Farbo Marco , Burgio Gaetano , Biasucci Daniele G. 
Published: June 2017

Introduction The central venous pressure (CVP) is the most commonly used static marker of preload for guiding fluid therapy in critically ill patients, though its usefulness remains controversial. Centrally inserted central catheters (CICCs) are the gold-standard devices for CVP monitoring but peripherally inserted central catheters (PICCs) may represent a valid alternative. We undertook a systematic review and meta-analysis with the aim to investigate whether the difference between PICC- and CICC-measured CVP is not significant. Methods We searched for clinical studies published in PubMed and EMBASE databases from inception until December 21st 2016. We included studies providing data on paired and simultaneous CVP measurement from PICCs and CICCs. We conducted two analyses on the values of CVP, the first one according to the total number of CVP assessments, the second one considering the number of patients recruited. Results Four studies matched the inclusion criteria, but only three of them provided data for the meta-analyses. Both analyses showed non-significant differences between PICC-measured and CICC-measured CVP: 1489 paired simultaneous CVP assessments (MD 0.16, 95%CI −0.14, 0.45, p = 0.30) on a total of 57 patients (MD 0.22, 95%CI −1.46, 1.91, p = 0.80). Both analyses showed no heterogeneity (I2 = 0%). Conclusions Available evidence supports that CVP monitoring with PICCs is accurate and reproduces similar values to those obtained from CICCs. The possibility to monitor CVP should not be used among clinical criteria for preferring a CICC over a PICC line.
Long-term clinical outcomes of the single-incision technique for implantation of implantable venous access ports via the axillary vein
Authors: Seo Tae-Seok , Song Myung Gyu , Kim Jun Suk , Choi Chul Won , Seo Jae Hong , Oh Sang Cheul , Kang Eun Joo , Lee Jae-Kwan , Lee Sung-yong 
Published: June 2017

Purpose To evaluate long-term clinical outcomes and complications of the single-incision technique for implantation of totally implantable venous access ports (TIVAPs) via the axillary vein. Materials and Methods A total of 932 TIVAPs were placed in 927 patients between May 2012 and October 2014 using a single-incision technique. Patients included 620 men and 307 women with a mean age of 60.0 years. TIVAPs were placed via the left (n = 475) and right (n = 457) axillary veins after making a single oblique vertical incision and medial side pocket without subcutaneous tunneling. We retrospectively reviewed medical records to evaluate status of the patients and TIVAPs, complications, and reasons for explantation. In patients who still had a TIVAP in place, we calculated the duration of TIVAP use from the cut-off day of November 1, 2015. Results Clinical follow-up was obtained for a total device service period of 311,069 days with a median indwelling time of 467 days (range: 3-1097 days). A total of 37 (4.0%) complications developed. Early complications (n = 4) were one case each of stenosis of the brachiocephalic vein by tumor growth, thrombosis of axillary vein, intravascular migration, and malfunction depending on patient's position. Late complications (n = 33) were suspected catheter-related blood stream infection (n = 23), local infection of the pocket (n = 4), symptomatic stenosis and thrombosis of central vein (n = 4), malfunction by fibrin sleeve (n = 1), and intravascular migration (n = 1). Conclusions A single-incision technique for TIVAP implantation via the axillary vein seems to be safe with a low risk of complication.
Perineal schwannoma: an unusual tumor and clinical presentation – first case with erectile dysfunction associated with this neoplasm
Authors: Cecconi Filippo , Maiolino Giuseppe , Lanzi Federico , Vittori Gianni , Gentile Filippo , Pizzirusso Gerardo , Barbanti Gabriele , Tripodi Sergio 
Published: June 2017

Introduction: Perineal schwannomas (PS) are very rare benign tumors with few cases reported in literature and none of these reports erectile dysfunction among clinical presentations. Case description: We report a case of PS with unusual clinical presentation showing erectile dysfunction associated with perineal pain and discomfort during defecation, and the postoperative residual pain and erectile dysfunction treatment. Conclusions: On the basis of a literature review of all cases reported and on our case reported, we have delineated a clinical, diagnostic, and therapeutic profile of PS, summarized in a useful table.
Comparison of Serum Vitamin D between Fertile and Infertile Men in A Vitamin D Deficient Endemic Area: A Case-Control Study
Authors: Akhavizadegan Hamed , Karbakhsh Mojgan 
Published: June 2017

Introduction The aim of this study was to compare serum vitamin D between fertile and infertile men in endemic area of vitamin D deficiency. The role of vitamin D in all aspects of human health has attracted a great interest. Vitamin D effect on female fertility and to a lesser extent in men is under investigation. Previous researchers have found meaningful positive relationship between semen quality and serum vitamin D level. However, in endemic area of vitamin D deficiency, this effect is under question. Methods Serum 25-OH-Vitamin D was compared between infertile male patients and fertile control group. Infertile cases were from patients of our infertility clinic and fertile controls from healthy cases with at least one child below 5 years of age. SPSS version 19 was used for statistical analysis (Kolmogorov-Smirnov test and Mann-Whitney test). Results Between 116 fertile and 114 infertile men who entered the study, serum level of 20 was a critical point, which patients with upper serum level had significantly better spermogram. In addition to it, even in vitamin D deficient patients and controls, fertile controls had higher serum vitamin D. Conclusions There is a positive correlation between serum level of vitamin D and spermogram quality, even in vitamin D deficient areas. Fertile people have a higher level of serum vitamin D in comparison to infertile patient in aforementioned areas.
Originalita v pojetí práva Evropské unie
Authors: Zibner Jan 
Published: June 2017

Příspěvek analyzuje kritérium originality jako pojmový znak autorského díla napříč právem Evropské unie, a to jak na poli legislativním, kde je ve směrnicové úpravě anglický pojem "original" definován různorodě, tak na poli judikatorním, kde je jeho výklad uchopen též dost nestabilně. Znak originality vyjadřuje míru duševní činnosti autora ve vztahu k výslednému výtvoru. Jako takový je tento znak odrazem předpokladu zachyceného již v Bernské úmluvě, která naznačuje neodmyslitelné spojení autora a jeho díla. Originalita pak krom jiného významově balancuje mezi původností a jedinečností coby dvěma základními leč mírou náročnosti požadavků na dílo odlišnými úrovněmi takového spojení. Příspěvek si proto klade za cíl objasnit v tomto směru unijní chápání originality.
Assessment of Methods and Results of Reproductive Occupational Epidemiology: Spontaneous Abortions and Malformations in the Offspring of Working Women
Authors: Hemminki Kari , Axelson Olav , Niemi Marja-Liisa , Ahlborg Gunnar 
Published: June 2017

Epidemiological studies relating occupational exposures of working women to spontaneous abortions and malformation are reviewed and some methodological considerations are presented. The reproductive epidemiology is less developed titan epidemiology in general and seems to involve some specific problems. The ascertainment of exposure and of outcome may be problematic. The exposures may be reported differently by the women depending on the outcome of the pregnancy; thus confirmation of exposure from an independent data source would be an asset. The recognition of spontaneous abortions by women is variable and this should be considered in the study design. An access to medical records could provide objective data on the outcome, but it may introduce other types of asymmetries.The types of occupational exposures of the women, suggested to carry a risk of spontaneous abortions, include anesthetic agents, laboratory work, copper smelting, soldering, and chemical sterilization using ethylene oxide and glutaraldehyde. Maternal employment in laboratories and exposure to solvents has been linked to a risk of congenital malformations in the offspring in five studies. Data on the teratogenic effects of anesthetic gases has been conflicting. In one study, employment in copper smelting was associated with malformations in the offspring.
Genomic patterns in Acropora cervicornis show extensive population structure and variable genetic diversity
Authors: Drury Crawford , Schopmeyer Stephanie , Goergen Elizabeth , Bartels Erich , Nedimyer Ken , Johnson Meaghan , Maxwell Kerry , Galvan Victor , Manfrino Carrie , Lirman Diego 
Published: June 2017

AbstractThreatened Caribbean coral communities can benefit from high‐resolution genetic data used to inform management and conservation action. We use Genotyping by Sequencing (GBS) to investigate genetic patterns in the threatened coral, Acropora cervicornis, across the Florida Reef Tract (FRT) and the western Caribbean. Results show extensive population structure at regional scales and resolve previously unknown structure within the FRT. Different regions also exhibit up to threefold differences in genetic diversity (He), suggesting targeted management based on the goals and resources of each population is needed. Patterns of genetic diversity have a strong spatial component, and our results show Broward and the Lower Keys are among the most diverse populations in Florida. The genetic diversity of Caribbean staghorn coral is concentrated within populations and within individual reefs (AMOVA), highlighting the complex mosaic of population structure. This variance structure is similar over regional and local scales, which suggests that in situ nurseries are adequately capturing natural patterns of diversity, representing a resource that can replicate the average diversity of wild assemblages, serving to increase intraspecific diversity and potentially leading to improved biodiversity and ecosystem function. Results presented here can be translated into specific goals for the recovery of A. cervicornis, including active focus on low diversity areas, protection of high diversity and connectivity, and practical thresholds for responsible restoration.
Synthesis and In Vitro Study of Hybrid Heterocyclic's as Potential Nematicidal Agents
Authors: Srinivas A. , Sunitha M. , Karthik P. , Nikitha G. , Raju K. , Ravinder B. , Anusha S. , Rajasri T. , Swapna D. , Swaroopa D. , Srinivas K. , Vasumathi Reddy K. 
Published: June 2017

A series of novel 5‐((3aR,5S,6S,6aR)‐6‐((1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)‐2,2‐dimethyltetrahydrofuro[2,3‐d][1,3]dioxol‐5‐yl)‐3‐(4‐fluorophenyl)‐6‐phenyl‐3,3a,5,6‐tetrahydroisoxazolo[3,4‐d]thiazoles 10a–g were synthesized by the reaction of chalcone derivatives of 2‐((3aR,5S,6S,6aR)‐6‐((1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)‐2,2‐dimethyltetrahydrofuro[2,3‐d][1,3]dioxol‐5‐yl)‐3‐phenylthiazolidin‐4‐one 9 with hydroxylamine hydrochloride. The chemical structures of newly synthesized compounds were elucidated by IR, NMR, MS, and elemental analysis. The compounds 10 a–g were evaluated for their nematicidal activity against Dietylenchus myceliophagus and Caenorhabditis elegans; compound 10e and 10f showed appreciable nematicidal activity. Further, the compounds 10a – g were screened for their antifungal activity against Candida albicans (ATCC 10231), Aspergillus fumigates (HIC 6094), Trichophyton rubrum (IFO 9185), and Trichopyton mentagrophytes (IFO 40996). The compounds 10b and 10f displayed notable antifungal activity against all the microorganisms employed. The activity of these compounds is almost equal to the standard. It is also interesting to note that the compounds 10b and 10f and 10g showed activity towards C. albicans at the concentration of 3.75 μM, which is less than the concentration of the standard Amphotericin B.
Proximate, mineral composition and antioxidant activity of traditional small millets cultivated and consumed in Rayalaseema region of south India
Authors: Vali Pasha Kotwal , Ratnavathi Chamarthy Venkata , Ajani Jayanna , Raju Dugyala , Manoj Kumar Sriramoju , Beedu Sashidhar Rao 
Published: June 2017

AbstractBACKGROUNDMillets are a diverse group of small seeded grasses, widely grown around the world as cereal foods. This communication details the proximate, mineral profile and antioxidant activity of six different small millets (Finger, Foxtail, Proso, Little, Barnyard and Kodo millets) and their 21 cultivars that are traditionally cultivated and consumed in the region of Ralayaseema, south India.RESULTSThe proximate analysis revealed that these millets are rich in protein, fat, ash (mineral), total dietary fibre and total phenols with appreciable antioxidant activity. However, starch and amylose content was comparatively lower as compared to major millet sorghum. ICP‐MS analysis of small millets demonstrated that they are rich in minerals such as Ca, P, K, Mg, Fe, Cu, Zn, Mn, Cr, Mo and Se.CONCLUSIONFinger and kodo millets were found to be nutritionally superior over other small millets. The results suggest that small millets have a potential to provide food security and can combat micronutrient malnutrition. © 2017 Society of Chemical Industry
Psychiatry 2017: Acknowledging Complexity While Avoiding Defeatism
Authors: Maj M. 
Published: June 2017

In the past few years, it has become a sort of cliché to state that psychiatry is in a crisis. In particular, it has been repeatedly argued that: (a) psychiatric diagnoses are invalid; (b) psychiatric research has not progressed significantly (in particular, it has not been able to identify “the cause” of schizophrenia, depression or bipolar disorder); (c) psychiatric treatments are of limited value, and their widespread use has not been able to reduce the incidence of mental disorders. This perception of crisis has been at least in part generated by an identification of mainstream psychiatry with the neo-kraepelinian paradigm, so that the crisis of confidence in that paradigm has expanded into a crisis of confidence in the psychiatric discipline. According to Kuhn, the crisis of confidence in a paradigm is accompanied by a period of “extraordinary science”, marked by a proliferation of competing methodologies, the proposition of a variety of divergent solutions for the problem defining the crisis, and the recourse to philosophy and to debate over fundamentals of the discipline. The crisis of confidence in the neo-kraepelinian paradigm has generated such a period, in which we are all now immersed. In this presentation, I will summarize the main components of the neo-kraepelinian paradigm; I will illustrate why that paradigm has failed, or at least has lost people's confidence; and will summarize the main elements which are emerging in the current period of “extraordinary science”.Disclosure of interestThe author has not supplied his declaration of competing interest.
Assertive Interventions for First Episode Psychoses: The Italian Experience
Authors: Meneghelli A. 
Published: June 2017

In Italy, despite the favourable conditions created by the 1978 reform law and the community psychiatry, at the end of the past century there were no culture or initiatives oriented to innovative and evidence-based founded interventions in early psychosis. The watershed was the setting up in the MHD of Niguarda (Milan) of Programma 2000, addressed to FEP and HR mostly inspired by the knowledge of existing studies and experiences and with the recommended characteristics of specificity, multicomponentiality, assertiveness and doctrinal orientation. From the very start, one fundamental aim was to disseminate information, training, supervision, and to raise consensus and initiatives throughout Italy, as well as to improve international links. In many ways, the consequences have been extremely positive. In 2005, Angelo Cocchi and Programma 2000 team founded the AIPP (Italian Association for Early Intervention in Psychosis), now named Italian Association for Prevention and Early Intervention in Mental Health. Over the years, the Association has organized conferences, scientific days, working network, two national surveys on EIS and produced a document to favour their development. The results of the second survey are the more updated and articulated about the number of early interventions services, their characteristics and distribution in the different Italian regions. The survey conclusion is that EI Services implementation in Italy has been proceeding, albeit slowly. Nevertheless, there is still a great variability of therapeutic strategies and further efforts are then necessary to stimulate resources allocation as well as to assess and address adherence and fidelity to guidelines recommendations.Disclosure of interestThe author has not supplied his declaration of competing interest.
Barriers to Gender Equality in Career Advancement and Leadership
Authors: Wasserman D. 
Published: June 2017

Life as a researcher includes a large amount of competition and a heavy workload. Professor's tasks comprise, besides their own research, to lead your research team, to have the responsibility for higher education, expertise in diverse contexts, review of scientific articles, to seek financial support, to work with national and international committees, to serve in administrative posts at the university and in international associations, to write articles, books and book chapters, to attend meetings and conferences, and to address the many other tasks that may arise throughout one's career. This makes one dependent on skillful co-workers, which should not be taken for granted. Given the constant flow of incoming requests, one has to think and choose before agreeing to commit to a task at hand, in order to not set aside your own research. This demands a high capability to prioritize. The choice of a life partner who can share both professional and private interests, a partner who understands, encourages and supports, while at the same time gives the necessary critical feedback, is a treasure. Freud said “love and work are the cornerstones of our humanness”, but work must be pleasurable thus try to combine work, love, and play.Disclosure of interestThe author has not supplied his declaration of competing interest.
Gender Identity Issues in Children and Adolescents
Authors: Steensma T.D. 
Published: June 2017

Gender identity issues in children and adolescents.Gender dysphoria (GD) refers to the significant distress due to the incongruence between assigned gender at birth and experienced gender. Over the last decade, the care for prepubescent children and adolescents with GD is rapidly changing and there is a growing number of specialized gender clinics for youth. However, the offered care between countries is very different and the best clinical practice in this population is still controversial and under debate among dedicated professionals.The current presentation will focus on providing a clinical picture of children and adolescents referred to gender identity clinics. For prepubescent children the focus will be on the present knowledge about the psychosexual development of these children and treatment & counseling approaches are presented and discussed. With regard to the adolescents, medical treatment approaches are presented and discussed, followed by the results from the only follow-up study on medical treatment in adolescents with GD.Disclosure of interestThe author has not supplied his declaration of competing interest.
Developing a Curriculum and Standards for Psychiatric Training in Perinatal Mental Health
Authors: McDonal E. 
Published: June 2017

This presentation will inform the audience about the workforce issues in England in relation to Perinatal Psychiatry. The talk will illustrate the methods being utilised within the Royal College of Psychiatrists to develop the skills and competencies of clinicians. Intensive training courses, curriculum development and an innovative bursary scheme for consultant psychiatrists will be described.Disclosure of interestThe author has not supplied his declaration of competing interest.
A Reinforcement-learning Account of Tourette Syndrome
Authors: Maia T. 
Published: June 2017

BackgroundTourette syndrome (TS) has long been thought to involve dopaminergic disturbances, given the effectiveness of antipsychotics in diminishing tics. Molecular-imaging studies have, by and large, confirmed that there are specific alterations in the dopaminergic system in TS. In parallel, multiple lines of evidence have implicated the motor cortico-basal ganglia-thalamo-cortical (CBGTC) loop in TS. Finally, several studies demonstrate that patients with TS exhibit exaggerated habit learning. This talk will present a computational theory of TS that ties together these multiple findings.MethodsThe computational theory builds on computational reinforcement-learning models, and more specifically on a recent model of the role of the direct and indirect basal-ganglia pathways in learning from positive and negative outcomes, respectively.ResultsA model defined by a small set of equations that characterize the role of dopamine in modulating learning and excitability in the direct and indirect pathways explains, in an integrated way: (1) the role of dopamine in the development of tics; (2) the relation between dopaminergic disturbances, involvement of the motor CBGTC loop, and excessive habit learning in TS; (3) the mechanism of action of antipsychotics in TS; and (4) the psychological and neural mechanisms of action of habit-reversal training, the main behavioral therapy for TS.ConclusionsA simple computational model, thoroughly grounded on computational theory and basic-science findings concerning dopamine and the basal ganglia, provides an integrated, rigorous mathematical explanation for a broad range of empirical findings in TS.Disclosure of interestThe author has not supplied his declaration of competing interest.
Mental Health of Child & Adolescent Refugees: The Hidden Momentum for a Paneuropean Call for Action
Authors: Kanellopoulos A. 
Published: June 2017

IntroductionOver one percent of the world's population are currently uprooted. Over half of the world's displaced population are children.ObjectiveThere is considerable evidence that refugee children are at significant risk of developing psychological disturbance as they are subject to a number of risk factors.AimConsistent research findings show that as the number of risk factors accumulates for children, the likelihood that they will develop psychological disturbance dramatically increases.MethodsTraumatic events can have an effect on a child's emotional, cognitive and moral development because they influence the child's self-perceptions and expectations of others. The multidimensional effects of trauma on children and their families are compounded by forced uprooting, multiple losses and the myriad changes brought about by migration. Mental health services can be key to restoring basic psychological functioning and to supporting resilience and positive coping strategies for children, adolescents and adults.ResultsRefugee children are a silent group that are easily overlooked. Our attitude toward young refugees and their families will determine the burden of trauma, not only on their adult future but also on our community.ConclusionsAn empathic and mentalizing attitude, secure sheltering, addressing health and educational needs will create a sense of stability and confidence. This is the very first step to favour, for these future adults.Disclosure of interestThe author has not supplied his/her declaration of competing interest.