bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local versus intravenous injections of skeletal muscle precursor cells in nonhuman primates with acute or chronic intrinsic urinary sphincter deficiency
Authors: Williams J. Koudy , Badlani Gopal , Dean Ashley , Lankford Shannon , Poppante Kimberly , Criswell Tracy , Andersson Karl-Erik 
Published: October 2016

Abstract
Background
Many factors may influence the efficacy of cell therapy for intrinsic urinary sphincter deficiency (ISD), including the route of administration of the cells and the condition of the sphincter. The goal of this study was to compare local versus intravenous administration of autologous skeletal muscle precursor cells (skMPCs) when administered to nonhuman primates (NHPs) with either acute or chronic ISD.

Methods
Thirty-two adult female monkeys were divided into eight groups (n = 4/group): (1) control; (2) surgically induced ISD/no treatment; (3) acute ISD (6-week duration)/local vehicle only; (4) acute ISD/local skMPC injection; (5) acute ISD/systemic skMPC; (6) chronic ISD (6-month duration)/local vehicle; (7) chronic ISD/local skMPC; (8) chronic ISD/systemic skMPC. Maximal urethral pressures (MUP) were measured prior to ISD, prior to treatment and at 3 and 6 months following treatment. Quantitative histology was used to measure muscle/collagen content, somatic innervation, and vascularity of the sphincter complexes.

Results
In NHPs with acute ISD both systemic and local administration of skMPCs increased resting MUP values and sphincter muscle content (p < 0.05 vs. ISD/vehicle). However, the effects of systemic skMPC administration were significantly lower than those of local injection (p > 0.05). In NHPs with chronic ISD local skMPC administration had reduced (compared to NHPs with acute ISD) effects on MUP and sphincter muscle values (p < 0.05 vs. acute ISD/skMPC); systemic administration had no effect. Pudendal nerve-stimulated increases in MUP were significant only in acute ISD NHPs with local skMPC treatment (p < 0.05 vs. resting MUP). The extent of sphincter vascularization and innervation were directly related to MUP and sphincter muscle content.

Conclusions
Both the chronicity of ISD and the route of cell injection influence the efficacy of cell therapy in monkey models of ISD. This may be related to the relative ability of cells to stimulate vascularization and re-innervation in these different treatment conditions.
Mediation analysis of severity of needs, service performance and
outcomes for patients with mental disorders
Authors: Roux Paul , Passerieux Christine , Fleury Marie-Josée 
Published: October 2016

BackgroundNeeds and service performance assessment are key components in improving
recovery among individuals with mental disorders.AimsTo test the role of service performance as a mediating factor between
severity of patients' needs and outcomes.MethodA total of 339 adults with mental disorders were interviewed. A mediation
analysis between severity of needs, service performance (adequacy of
help, continuity of care and recovery orientation of services) and
outcomes (personal recovery and quality of life) was carried out using
structural equation modelling.ResultsThe structural equation model provided a good fit with the data. An
increase in needs was associated with lower service performance and worse
outcomes, whereas higher service performance was associated with better
outcomes. Service performance partially mediated the effect of patient
needs on outcomes.ConclusionsPoorer service performance has a negative impact on outcomes for patients
with the highest needs. Ensuring more efficient services for patients
with high needs may help improve their recovery and quality of life.
The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit
Authors: Solé Laura , Roig Sara R. , Vallejo-Gracia Albert , Serrano-Albarrás Antonio , Martínez-Mármol Ramón , Tamkun Michael M. , Felipe Antonio 
Published: October 2016

ABSTRACT
The voltage-dependent K+ channel Kv1.3 (also known as KCNA3), which plays crucial roles in leukocytes, physically interacts with KCNE4. This interaction inhibits the K+ currents because the channel is retained within intracellular compartments. Thus, KCNE subunits are regulators of K+ channels in the immune system. Although the canonical interactions of KCNE subunits with Kv7 channels are under intensive investigation, the molecular determinants governing the important Kv1.3– KCNE4 association in the immune system are unknown. Our results suggest that the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for such an interaction. However, this element is apparently not involved in modulating Kv1.3 gating. Furthermore, the KCNE4-dependent intracellular retention of the channel, which negatively affects the activity of Kv1.3, is mediated by two independent and additive mechanisms. First, KCNE4 masks the YMVIEE signature at the C-terminus of Kv1.3, which is crucial for the surface targeting of the channel. Second, we identify a potent endoplasmic reticulum retention motif in KCNE4 that further limits cell surface expression. Our results define specific molecular determinants that play crucial roles in the physiological function of Kv1.3 in leukocytes.
VISIT-TS: A multimedia tool for population studies on tic disorders
Authors: Vachon M. Jonathan , Striley Catherine W. , Gordon Mollie R. , Schroeder Miriam L. , Bihun Emily C. , Koller Jonathan M. , Black Kevin J. 
Published: October 2016

Population-based assessment of Tourette syndrome (TS) and other tic disorders produces a paradox. On one hand, ideally diagnosis of tic disorders requires expert observation. In fact, diagnostic criteria for TS explicitly require expert assessment of tics for a definite diagnosis. On the other hand, large-scale population surveys with expert assessment of every subject are impracticable. True, several published studies have successfully used expert assessment to find tic prevalence in a representative population (e.g. all students in a school district). However, extending these studies to larger populations is daunting. We created a multimedia tool to demonstrate tics to a lay audience, discuss their defining and common attributes, and address features that differentiate tics from other movements and vocalizations. A first version was modified to improve clarity and to include a more diverse group in terms of age and ethnicity. The result is a tool intended for epidemiological research. It may also provide additional benefits, such as more representative minority recruitment for other TS studies and increased community awareness of TS.
Evaluation of quality of life in women with breast cancer, with particular emphasis on sexual satisfaction, future perspectives and body image, depending on the method of surgery
Authors: Słowik Agnieszka , Jabłoński Marcin , Michałowska-Kaczmarczyk Anna , Jach Robert 
Published: October 2016

Cel pracyW artykule analizie poddano jakość życia kobiet z rakiem piersi, ze szczególnym uwzględnieniem wskaźników satysfakcji seksualnej, perspektyw na przyszłość oraz obrazu ciała w zależności od zastosowanej metody leczenia operacyjnego.MetodaDo badania zakwalifikowano 42 kobiety w wieku 35 do 70 lat, 3 miesiące po przebytym leczeniu chirurgicznym z powodu wczesnego raka piersi, poddanych chemioterapii uzupełniającej. Jako narzędzia badawcze zastosowano dwa kwestionariusze EORTC: QLQ-C30 i BR23 oraz kwestionariusz funkcji seksualnych: PL-FSFI.WynikiNie wykazano istotnej różnicy w zakresie ogólnej jakości życia w zależności od rodzaju zabiegu chirurgicznego. Największe dolegliwości w zakresie dolegliwości miejscowych zgłaszały chore pooddane operacji oszczędzającej (=BCT) z limfadenektomią pachową. U kobiet poddanych mastektomii wykazano wyższy poziom funkcjonowania poznawczego, natomiast większe nasilenie systemowych objawów ubocznych w porównaniu do pacjentek po BCT. Chore u których zabieg dotyczył piersi prawej raportowały więcej problemów w funkcjonowaniu seksualnym (p=0,034). W analizie regresji wielorakiej wykazano dodatnią korelację zmiennej funkcjonowanie emocjonalne z oceną przyszłych perspektyw (p=0,01) oraz oceną obrazu ciała (p=0,007).WnioskiRodzaj techniki operacyjnej nie wpływa na ogólną jakość życia oraz na satysfakcję seksualną operowanych kobiet. Problemy z pamięcią i koncentracją uwagi nie korelują bezpośrednio z nasileniem objawów ubocznych leczenia i jako takie wymagają niezależnej diagnostyki. U pacjentek, u których zabieg dotyczył piersi po stronie ręki prawej (dominującej) należy rozważyć potrzebę konsultacji seksuologicznej. Kobiety z rakiem piersi, u których obserwuje się zaburzenia emocjonalne w okresie 3 miesięcy po zabiegu operacyjnym posiadają zwiększone ryzyko zaburzeń w obrazie ciała jak i w ocenie przyszłych perspektyw.
Social media practices on Twitter: maximising the impact of cardiac associations
Authors: Gallagher Robyn , Psaroulis Trifon , Ferguson Caleb , Neubeck Lis , Gallagher Patrick 
Published: October 2016

Twitter is a social media platform often used by cardiac professional associations to engage and inform their members and the public. However, the effectiveness of the strategy is seldom assessed or published. Aim: This study evaluates the Twitter activities of nine cardiac professional associations. Each organisation's purpose and stakeholders were described individually and classified. Extracted Tweets (n=3920) were content-analysed and metrics were determined. Results: There was alignment between the associations' mission statements and their Twitter activities. However, most Tweets were one-directional, disseminating research-based evidence/professional education materials and communicating association events and activities, as well as using hashtags to enable searching. Conclusion: Social media communication by cardiac professional associations through Tweets is an important activity; however, at present, the use of dialogue and conversations are not fully realised and could be used more strategically.
Choice of planned place of birth for women with diet-controlled gestational diabetes mellitus
Authors: Brown Anna Maria , Rajeswari Devannas , Bowles Angie 
Published: October 2016

Background: Women with diet-controlled gestational diabetes have been excluded from birthing in one midwife-led birth centre due to an assumed risk of complications. Aims: This study aimed to examine the rates of adverse outcomes for women diagnosed with gestational diabetes who have controlled their hypoglycaemia through dietary change, but who may be excluded from birthing in a midwife-led centre owing to risk of complications, to identify whether outcomes are the same for these women as for other low-risk women giving birth in one local maternity unit. Methods: Retrospective analysis was conducted of data on low-risk women giving birth at a maternity unit in the South East of England to compare the birth outcomes of women with or without gestational diabetes. Data were analysed in Microsoft Excel and presented as descriptive statistics. Findings: In 2014, a total of 164 out of 4032 women who gave birth at the maternity unit had gestational diabetes. Among these, 89 were controlled through diet alone. Data for 4 months in 2015 were also examined for 57 women with gestational diabetes. Conclusions: The mode of delivery and outcomes for the women in this cohort who remained normoglycaemic have been found to be in line with the general outcomes for all women at this hospital during the study period. The women diagnosed with gestational diabetes but well controlled on diet had similar outcomes to low-risk women giving birth at the maternity unit. The small sample size means further work is needed to confirm the findings, but indicates that the option of using the birth centre may be considered a reasonable alternative for these women.
Should midwives consider associated psychological factors when caring for women who are obese?
Authors: Wahedi Maureen 
Published: October 2016

Background: In the UK, 15.6% of the maternal population are obese (body mass index ≥ 30 kg/m2), posing serious health consequences to the woman and fetus. Current maternal weight management interventions, focusing on healthy diet and exercise, fail to adequately address this problem, which may be attributable to a bidirectional association between maternal obesity and psychological factors not being addressed. Aims: The aim of this reflective literature review is to determine whether there is sufficient evidence to suggest that midwives should consider psychological factors when caring for women who are obese. Methods: A literature review was undertaken of papers from academic journals, dissertations, theses and professional magazines, published between 2005 and 2015. A total of 529 articles were returned, of which 10 were selected for review. Findings: Critical analysis of 10 relevant studies confirms an association between maternal obesity and women's psychological wellbeing. Many midwives are aware of this relationship, but feel they lack the knowledge and interpersonal competence to address such issues. Conclusions: Midwives require greater understanding of psychological complexities surrounding pregnancy weight management, and training in person-centred counselling techniques, in order to optimise health outcomes for women and neonates.
Increasing uptake of chlamydia screening in general practice
Authors: Strivens Karen 
Published: October 2016

Chlamydia screening rates remain sub-optimal in the UK, but awareness raising using multi-media, plus training and education for clinicians, can improve uptake. Karen Strivens outlines findings of a pilot study to determine practical solutions in general practice. Chlamydia infection poses a huge challenge to public health and to the NHS, hence current policies to enhance screening in 15–24 year olds, the highest risk group ( Department of Health, 2009 ; National Chlamydia Screening Programme 2012 ; Public Health England, 2014 ). Despite efforts to reduce infection rates through mass media campaigns encouraging routine screening, rates remain sub-optimal and chlamydia infection continues to rise ( NHS Choices, 2010 ; Gobin et al, 2013 ). To address this, a pilot study was undertaken by a large general practice in north west England to improve screening uptake, using a three-pronged approach: raising awareness of chlamydia infection and available screening services via posters and text messages and online; providing practice staff with education and training to encourage uptake of screening in contraceptive and sexual health appointments; and initiating an evening drop-in service. Although the drop-in service did not achieve the anticipated attendance rate, findings highlighted a significant increase in chlamydia screening following the awareness-raising local multi-media campaign and education and training of staff.
Ptolemaic Mummy Stuffings: An Intriguing Ptolemaic Scholar’s Text in the Yale Collection (P.CtYBR 5018)
Authors: Johnson William A. 
Published: October 2016

Abstract
Beinecke papyrus P.CtYBR inv. 5018 consists of a series of well-defined entries, each with three elements: (1) an ordinal number (surviving are “10th” through “15th”); (2) the lemma, no more than a phrase, apparently excerpted from an unknown prose text; (3) literary examples or verbatim quotations, presumably intended to illustrate the content of the lemma. Quoted are a passage from Odyssey 11 and two trimeter lines from an unknown tragedy or tragedies. The contents of the prose text from which the lemmata derive is not clear, but appears to regard poetics or poetic composition.
A Greek Mathematical Papyrus from the Cairo Museum
Authors: Aish Seham Diab Almasry 
Published: October 2016

Abstract
This papyrus contains three texts and drawings: an account in two columns (hand 1) and three geometrical diagrams partly overlapping the right column (hand 2). The verso has two texts written by two hands: (1) a table which produces doubling entries 2, 4, 8, 16, 32, 64, 128, 256, i.e. powers of 2 up to the 8th power; (2) an account about 4 silver drachmae at the value of 1,950 bronze drachmae.
Phylenzahl und Phylenzyklus in Hermupolis und Oxyrhynchos
Authors: Essler Holger 
Published: October 2016

Abstract
While the tribal cycles in Oxyrhynchos are fairly well attested from AD 206 until 271, no system has been proposed for other periods or other metropoleis. On the basis of recently published texts a first attempt is made to reconstruct the tribal cycles in Oxyrhynchus and Hermopolis for the later part of the 4th century.
Fragment eines Kaufvertrags mit Kreditierung des Kaufpreises (P.Heidelberg K. 234)
Authors: Förster Hans 
Published: October 2016

Abstract
This fragmentary deed of sale written in Sahidic probably originates from the city of Hermopolis because of the individuals involved. The legal situation is complicated as two different sums of money are mentioned: a credit of 2 solidi and another of 7 solidi. A woman sells a piece of land and the sale price is credited to the seller. The parties agree to withhold transfer of ownership rights until the buyer pays the full price.
An Arabic Acknowledgment of a Debt on Papyrus
Authors: Younes Khaled M. 
Published: October 2016

Abstract
This article presents the edition of the Arabic papyrus, document A.P. 980, which is currently kept at the papyrus collection of the Austrian National Library in Vienna (Papyrus Erzherzog Rainer). The document contains an acknowledgment of debt in money most probably in the form of a ḏikr ḥaqq. The document dates to Ǧumādā II 244/ September-October 858.
Creating task-based oral foreign language exams linked to the CEFR in higher education
Authors: Reisenleutner Sandra 
Published: October 2016

AbstractOral language exams at university often consist of an individual or group conversation with the examiner about topics dealt with during the semester. A question-and-answer format is applied and vocabulary and structures tested. As a consequence, the oral exam does not reflect action-oriented approaches that often form part of classroom activities and are also fostered by the CEFR. This article describes the process and outcomes to date of action research carried out at the University of Sheffield and the University of Nottingham since 2014. The starting point is that many courses are linked to CEFR levels, which I wanted to include in oral language exams by working with descriptors. The article illustrates ways of making oral language exams more task-based, while still ensuring that topics, structures and vocabulary dealt with during the semester are incorporated. The process of changing the exam is described and examples are given. I also pose the question of how level descriptors of the CEFR might be linked to marking schemes and grading systems of British universities.
Plurilingual proficiency as a learning objective for a multilingual curriculum in the study of business in Finland
Authors: Schlabach Joachim 
Published: October 2016

AbstractPlurilingual skills are among the key skills required in international business communication. Employees working in international business operations use multiple languages concurrently, switch between them, and mediate between different languages and cultures. Up until now however, the language teaching accompanying business studies at universities has aimed at developing proficiencies geared to single languages. Plurilingual skills such as language alternation, code-switching, mediation, and transfer strategies have not been taken into account. Learning objectives that satisfy the particular requirements of multilingual individuals are thus missing from the curriculum. The Pluriling study, a didactically aligned analysis of the language requirements of the alumni of the Turku School of Economics, presents empirically reliable data that, in the first instance, describes the use of multiple languages in international business communications. Based on answers to open questions, typical plurilingual skills and strategies are defined and summarised under the term
On the Calabi-Yau equation in the
Kodaira-Thurston manifold
Authors: Vezzoni Luigi 
Published: October 2016

Abstract
We review some previous results about the Calabi-Yau equation on the Kodaira-Thurston manifold
equipped with an invariant almost-Kähler structure and assuming the volume form T2-invariant. In particular,
we observe that under some restrictions the problem is reduced to aMonge-Ampère equation by using the
ansatz ˜~ω = Ω− dJdu + da, where u is a T2-invariant function and a is a 1-form depending on u. Furthermore,
we extend our analysis to non-invariant almost-complex structures by considering some basic cases and we
finally take into account a generalization to higher dimensions.
Joint weak hazard rate order under
non-symmetric copulas
Authors: Pellerey Franco , Spizzichino Fabio 
Published: October 2016

Abstract
A weak version of the joint hazard rate order, useful to stochastically compare not independent
random variables, has been recently defined and studied in [4]. In the present paper, further results on this
order are proved and discussed. In particular, some statements dealing with the relationships between the
jointweak hazard rate order and other stochastic orders are generalized to the case of non symmetric copulas,
and its relations with some multivariate aging notions (studied in [2]) are presented. For this purpose, the new
notions of Generalized Supermigrative and Generalized Submigrative copulas are defined. Other new results,
examples and discussions are provided as well.
Telling True Lies. Metanarration, Intertextuality and (Un)reliability in Holberg’s Iter subterraneum
Authors: Velle Thomas 
Published: October 2016

Abstract
Scholarship on Ludvig Holberg’s imaginary voyage Iter subterraneum has noted that the credibility and reliability of both the narrator Klim, and his narration are problematized throughout the text. In doing so, scholars have simplified the text’s narratological structure. This article defamiliarizes the (un)reliability of Klim’s narration by distinguishing three levels in the text: Klim’s intentional discourse, which aims at authenticating the narration, a second level on which the authenticating function of Klim’s discourse is undermined by intertextual links with classical and modern authors, and thirdly, the role of Abeline as the translator of Klim’s text into Latin, which complicates Klim’s reliability even more. These levels and their interactions are explored by a close reading of metanarrative comments in Klim’s discourse, in order to understand the narratological dynamics in Holberg’s text more profoundly and, thereby, to deepen the scholarly view on Klim’s (un)reliability.
Ingvar Ambjørnsens hytte-noir
Authors: Rees Ellen 
Published: October 2016

Abstract
This article considers links between contemporary Norwegian writer Ingvar Ambjørnsen’s novel Natten drømmer om dagen (2012; The night dreams of the day) and the concept of noir, both in relation to more traditional film noir, to classic hard-boiled crime fiction, and to the recent trend in crime fiction and television known popularly as “Nordic noir”. The author argues that Ambjørnsen reworks key elements of noir aesthetics and thematics, for example relocating the setting from the more typical “urban jungle” to an equally dark and brooding forest landscape. Ambjørnsen simultaneously activates and dismantles tropes associated with both Norwegian identity (nature, the vacation cabin) and with noir (the anti-hero, the femme fatale) to create a complex social critique of late modern Norwegian society.