bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes
Authors: Kawase Atsushi , Hashimoto Ryota , Shibata Mai , Shimada Hiroaki , Iwaki Masahiro 
Published: March 2017

Background and Objectives: Diclofenac (DIC) is metabolized to reactive metabolites such as diclofenac acyl-β-d-glucuronide (DIC-AG). It is possible that such reactive metabolites could cause tissue damage by formation of covalent protein adducts and other modification of cellular proteins or by induction of immune responses against its covalent protein adducts. However, the detailed mechanisms of idiosyncratic drug-induced liver injury (DILI) have been unclear. The objective is to clarify the involvement of DIC-AG and 4′hydroxydiclofenac (4′OH-DIC) in acute DILI. Methods: We examined the effects of inhibiting DIC-AG and 4′OH-DIC production on covalent protein adduct formation and lactate dehydrogenase leakage using sandwich-cultured rat hepatocytes (SCRHs). Results: After pretreatment of SCRH with (−)-borneol (BOR, a uridine diphosphate (UDP)-glucuronosyltransferase inhibitor) or sulfaphenazole (SUL, a cytochrome P450 2C9 inhibitor) for 30 minutes, intracellular concentrations of DIC, DIC-AG, and 4′OH-DIC were determined after further treating cells with 300 μM DIC for 3 hours. The decreased levels of reactive metabolites caused by BOR or SUL pretreatment resulted in decreased lactate dehydrogenase leakage from SCRH, although the formation of covalent protein adducts was not affected. Conclusion: These results suggested that both DIC-AG and 4′OH-DIC may be involved in acute cytotoxicity by DIC.
A multicenter randomized controlled trial of endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3)
Authors: Albers Gregory W , Lansberg Maarten G , Kemp Stephanie , Tsai Jenny P , Lavori Phil , Christensen Soren , Mlynash Michael , Kim Sun , Hamilton Scott , Yeatts Sharon D , Palesch Yuko , Bammer Roland , Broderick Joe , Marks Michael P 
Published: March 2017

Rationale Early reperfusion in patients experiencing acute ischemic stroke is effective in patients with large vessel occlusion. No randomized data are available regarding the safety and efficacy of endovascular therapy beyond 6 h from symptom onset. Aim The aim of the study is to demonstrate that, among patients with large vessel anterior circulation occlusion who have a favorable imaging profile on computed tomography perfusion or magnetic resonance imaging, endovascular therapy with a Food and Drug Administration 510 K-cleared mechanical thrombectomy device reduces the degree of disability three months post stroke. Design The study is a prospective, randomized, multicenter, phase III, adaptive, blinded endpoint, controlled trial. A maximum of 476 patients will be randomized and treated between 6 and 16 h of symptom onset. Procedures Patients undergo imaging with computed tomography perfusion or magnetic resonance diffusion/perfusion, and automated software (RAPID) determines if the Target Mismatch Profile is present. Patients who meet both clinical and imaging selection criteria are randomized 1:1 to endovascular therapy plus medical management or medical management alone. The individual endovascular therapist chooses the specific device (or devices) employed. Study outcomes The primary endpoint is the distribution of scores on the modified Rankin Scale at day 90. The secondary endpoint is the proportion of patients with modified Rankin Scale 0–2 at day 90 (indicating functional independence). Analysis Statistical analysis for the primary endpoint will be conducted using a normal approximation of the Wilcoxon–Mann–Whitney test (the generalized likelihood ratio test).
Frequency and locations of systemic metastases in Merkel cell carcinoma by imaging
Authors: Kouzmina Maria , Koljonen Virve , Leikola Junnu , Böhling Tom , Lantto Eila 
Published: March 2017

Background The primary neuroendocrine skin cancer, Merkel cell carcinoma (MCC), has a well-known predilection to metastasize systemically. However, the experience of systemic metastases in MCC is mainly disseminated through case reports due to the rarity of MCC. Purpose To elucidate the frequency and locations of systemic metastasis in MCC by reviewing the imaging of patients with metastatic MCC in a national cohort. Material and Methods Patients with diagnosed metastatic MCC by imaging studies in Finland during 1999–2012 were included in this study. We reviewed their imaging studies to evaluate the most frequent sites for systemic metastasis and determined the latency between the primary tumor diagnosis and systemic metastasis. The material includes 30 MCC patients with complete imaging series and 187 examinations, of which 102 (54%) were CT images. Results The mean latency from the primary tumor diagnosis to systemic metastasis was 2.1 years and the mean latency between the radiologic diagnosis of the metastases and death was 299 days. Metastases were recorded in several organ systems in most of the cases, and at least two separate metastatic sites in 63% of the cases. Metastatic spread was noted in 60% of the cases in distant lymph nodes. Liver and lungs were the most affected solid organs. Conclusion Systemic metastasis in MCC has no predilection site, basically every organ system can be involved. Most of the systemic metastases were recorded during the first two years after the MCC diagnosis.
Mobile hologram verification with deep learning
Authors: Soukup Daniel , Huber-Mörk Reinhold 
Published: March 2017

Abstract
Holograms are security features applied to security documents like banknotes, passports, and ID cards in order to protect them from counterfeiting. Checking the authenticity of holograms is an important but difficult task, as holograms comprise different appearances for varying observation and/or illumination directions. Multi-view and photometric image acquisition and analysis procedures have been proposed to capture that variable appearance. We have developed a portable ring-light illumination module used to acquire photometric image stacks of holograms with mobile devices. By the application of Convolutional Neural Networks (CNN), we developed a vector representation that captures the essential appearance properties of hologram types in only a few values extracted from the photometric hologram stack. We present results based on Euro banknote holograms of genuine and counterfeited Euro banknotes. When compared to a model-based hologram descriptor, we show that our new learned CNN representation enables hologram authentication on the basis of our mobile acquisition method more reliably.
Neutrophils regulate the lung inflammatory response via γδ T cell infiltration in an experimental mouse model of human metapneumovirus infection
Authors: Cheemarla Nagarjuna R , Baños-Lara Ma Del Rocío , Naidu Shan , Guerrero-Plata Antonieta 
Published: March 2017

Abstract
Neutrophils are the most abundant leukocytes in human circulation. They are the first immune cell population recruited to the sites of infection. However, the role of neutrophils to regulate host immune responses during respiratory viral infections is largely unknown. To elucidate the role of neutrophils in respiratory antiviral defense, we used an experimental mouse model of human metapneumovirus (HMPV) infection. HMPV, a member of the Paramyxoviridae family, is a leading respiratory pathogen causing severe symptoms, such as bronchiolitis and pneumonia, in young, elderly, and immunocompromised patients. We demonstrate that neutrophils are the predominant population of immune cells recruited into the lungs after HMPV infection. This led us to hypothesize that neutrophils represent a key player of the immune response during HMPV infection, thereby regulating HMPV-induced lung pathogenesis. Specific depletion of neutrophils in vivo using a mAb and simultaneous infection with HMPV exhibited higher levels of inflammatory cytokines, pulmonary inflammation, and severe clinical disease compared with HMPV-infected, competent mice. Interestingly, the lack of neutrophils altered γδ T cell accumulation in the lung. The absence of γδ T cells during HMPV infection led to reduced pulmonary inflammation. These novel findings demonstrate that neutrophils play a critical role in controlling HMPV-induced inflammatory responses by regulating γδ T cell infiltration to the site of infection.
Morbidity and Mortality Associated With Meningioma After Cranial Radiotherapy: A Report From the Childhood Cancer Survivor Study
Authors: Bowers Daniel C. , Moskowitz Chaya S. , Chou Joanne F. , Mazewski Claire M. , Neglia Joseph P. , Armstrong Gregory T. , Leisenring Wendy M. , Robison Leslie L. , Oeffinger Kevin C. 
Published: March 2017

Purpose Little is known about neurologic morbidity attributable to cranial radiotherapy (CRT) –associated meningiomas. Materials and Methods From 4,221 survivors exposed to CRT in the Childhood Cancer Survivor Study, a diagnosis of meningioma and onset of neurologic sequelae were ascertained. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% CIs to evaluate the factors associated with neurologic sequelae after subsequent meningioma. Results One hundred ninety-nine meningiomas were identified among 169 participants. The median interval from primary cancer to meningioma diagnosis was 22 years (5 to 37 years). The cumulative incidence of a subsequent meningioma by age 40 years was 5.6% (95% CI, 4.7% to 6.7%). CRT doses of 20 to 29.9 Gy (HR, 1.6; 95% CI,1.0 to 2.6) and doses ≥ 30 Gy (HR, 2.6; 95% CI, 1.6 to 4.2) were associated with an increased risk of meningioma compared with CRT doses of 1.5 to 19.9 Gy ( P < .001). Within 6 months before or subsequent to a meningioma diagnosis, 20% (30 of 149) reported at least one new neurologic sequela, including seizures (8.3%), auditory-vestibular-visual deficits (6%), focal neurologic dysfunction (7.1%), and severe headaches (5.3%). Survivors reporting a meningioma had increased risks of neurologic sequelae > 5 years after primary cancer diagnosis, including seizures (HR, 10.0; 95% CI, 7.0 to 15.3); auditory-vestibular-visual sensory deficits (HR, 2.3; 95% CI, 1.3 to 4.0); focal neurologic dysfunction (HR, 4.9; 95% CI, 3.2 to 7.5); and severe headaches (HR, 3.2; 95% CI, 1.9 to 5.4). With a median follow-up of 72 months after meningioma diagnosis (range, 3.8 to 395 months), 22 participants (13%) were deceased, including six deaths attributed to a meningioma. Conclusion Childhood cancer survivors exposed to CRT and subsequently diagnosed with a meningioma experience significant neurologic morbidity.
Do Consumers Take Advantage of Common Pricing Standards? An Experimental Investigation
Authors: Sugden Robert , Zheng Jiwei 
Published: March 2017

Gaudeul and Sugden [Gaudeul A, Sugden R (2012) Spurious complexity and common standards in markets for consumer goods. Economica 79(314):209–225] have hypothesized that when some but not all competing products are priced in a common standard, consumers who are liable to make errors in cross-standard price comparisons use decision rules that discriminate in favor of common-standard offers. Such behavior incentivizes sellers to use common standards. We report an experimental test of this hypothesis, using choice tasks similar to those represented in the Gaudeul–Sugden model. We find that offers priced in common standards were more likely to be inspected but less likely to be chosen, and that subjects gained little benefit from common pricing standards that applied to some but not all offers. Most subjects used “dominance editing” operations that eliminated transparently dominated offers, either as an initial shortlisting device or while offers were being sorted. Because these operations discriminate against common-standard offers, their use incentivizes sellers not to use common standards. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2016.2676 . This paper was accepted by Uri Gneezy, behavioral economics.
Budgeting Time for Dynamic Vehicle Routing with Stochastic Customer Requests
Authors: Ulmer Marlin W. , Mattfeld Dirk C. , Köster Felix 
Published: March 2017

Parcel services route vehicles to pick up parcels in the service area. Pickup requests occur dynamically during the day and are unknown before their actual request. Because of working hour restrictions, service vehicles only have a limited time to serve dynamic requests. As a result, not all requests can be confirmed. To achieve an overall high number of confirmed requests, dispatchers have to budget their time effectively by anticipating future requests. To determine the value of a decision, i.e., the expected number of future confirmations given a point of time and remaining free time budget, we present an anticipatory time budgeting heuristic (ATB) drawing on methods of approximate dynamic programming. ATB frequently simulates a problem’s realization to subsequently approximate the values for every vector of point of time and free time budget to achieve an approximation of an optimal decision policy. Since the number of vectors is vast, we introduce the dynamic lookup table (DLT), a general approach adaptively partitioning the vector space to the approximation process. Compared with state-of-the-art benchmark heuristics, ATB allows an effective use of the time budget resulting in anticipatory decision making and high solution quality. Additionally, the DLT significantly strengthens and accelerates the approximation process. The online appendix is available at https://doi.org/10.1287/trsc.2016.0719 .
Introduction of Paraserianthes falcataria in the traditional agroforestry â€˜humaâ€™ in Karangwangi Village, Cianjur, West Java, Indonesia
Authors: ISKANDAR JOHAN , ISKANDAR BUDIAWATI S. , PARTASASMITA RUHYAT 
Published: March 2017

Abstract. Iskandar J, Iskandar BS, Partasasmita R. 2017. Introduction of Paraserianthes falcataria in the traditional agroforestry â€˜humaâ€™ in Karangwangi Village, Cianjur, West Java, Indonesia. Biodiversitas 18:Â 295-303.This paper discusses the result of study on introduction of â€˜jengjenâ€™ (Sundanese name) (Paraserianthes falcataria (L.) Nielsen in development of traditional agroforestry, â€˜humaâ€™ in Village of Karangwangi, Sub-district of Cidaun, District of Cianjur, Province of West Java, Indonesia. Method used in this study was qualitative with ethnoecological and biological approach. Observation and deep interview with informants were used to collect data. The result of study shows that although the population of Karangwangi Village has increased, the forest decreased, and intensively penetrated market economy, the huma system has continually practiced by village people. Unlike in the past, nowadays, the huma has been practiced in the non-forest instead of the forest. The huma system has been modified by people to be more permanent of traditional agroforestry system, such as bamboo garden (kebon awi), mixed of wood trees (kebon kai), and mixed fruit and wood trees (talun). In addition, due to more intensive in cultivation of agricultural land, Karangwangi people have adopted and cultivated jengjen plant in the huma farming system that had initially introduced by the Forestry Office (Dinas Kehutanan) through the regreening program. Moreover, the jengjen plant has been adopted and cultivated by the village people, such as integrated in the development of traditional agroforestry huma. It is caused this plant has provided some benefits, such as to improve soil fertility and to provide economic benefits, and does not eliminate the swidden farming (huma) system tradition of the people.
Keywords:Â Ethnoecology, introduction, jeungjing, Karangwangi, traditional agroforestryÂ
Orchid inventory in Bantimurung-Bulusaraung National Park, South Sulawesi, Indonesia
Authors: PUSPITANINGTYAS DWI MURTI 
Published: March 2017

Abstract. Puspitaningtyas DM. 2017. Orchid inventory in Bantimurung-Bulusaraung National Park, South Sulawesi, Indonesia. Biodiversitas 18: 341-350. Bantimurung-Bulusaraung National Park, commonly abbreviated as Babul National Park, is in South Sulawesi. It occupies an area of 43,750 hectares between 119o34'17"-119o55'13" East and 4o42'49"-5o06'42" South. Babul National Park is an area in the transition zone between Asia and Australia and therefore has a unique flora and fauna. The study reported here aimed to inventory the orchid species in the Babul National Park area and to determine the orchid diversity in the area. The results of the study recorded approximately 60 orchid species found in Babul National Park. These were representative of 32 genera and consisted of 42 species of epiphytic orchids and 18 species of terrestrial orchids. The terrestrial orchid Habenaria beccarii and the epiphytic orchid Aerides inflexa were the most common orchids found, and were spread evenly throughout the Babul National Park area. Coelogyne celebensis and Aerides inflexa are endemic orchids of Sulawesi found within the Park. Three species of the genus Nervilia, i.e. N. punctata, N. plicata, and N. aragoana, were also found in this area. Some species of orchid such as Tropidia angulosa, Coelogyne rumphii and Dendrobium lampongense were found as new records in Sulawesi.
Keywords: Bantimurung-Bulusaraung National Park, inventory, orchid, South Sulawesi
Trees of tropical peatland forest influence on variability of water and carbon input through stemflow
Authors: ASTIANI DWI , MUJIMAN MUJIMAN , CURRAN LISA M. 
Published: March 2017

Abstract. Astiani D, Mujiman, Curran LM. 2017. Trees of tropical peatland forest influence on variability of water and carbon input through stemflow. Biodiversitas 18: 383-388. Hydrology controls the chemical and biotic processes in peatlands, influencing interactions among vegetation, nutrient dynamics, and carbon fluxes. The effects of forest degradation revealed severe changes in the hydrological cycle such as variability of water input on forest floor, soil water storage and the ability to abstract water from soil depth. A study had been conducted to investigate part of the water cycle, the amount of water and carbon input through stemflow into peatland forest floor for 2 years. Stemflow was measured on 20 trees of each 3 blocks of forest with tree diameter ranging from 10-30 cm dbh using stemflow collectors. Then the trees were grouped to three bark types (smooth, mid, and coarse) to investigate whether it had influenced the inputs. Results showed that with mean annual precipitation of 3282 Â± 128mm, annual mean stemflow for the area was 18.2% of the rainfall. Further analysis demonstrated that tree species with smoother bark textures tend to bring more water to forest floor compared to mid and coarse bark textures (46% and 42.5% more than coarse and intermediate consecutively). The carbon input also show similar trend. The results implied that tree species influence the amount of stemflow and significant amount of water could be slower down come to forest floor through this mechanism and protected forest soil.
Keywords: Annual stemflow, peatland forest, hydrological flow, tree barks, tree species
Association of arbuscular mycorrhizal fungi (AMF) with Brachiaria precumbens (Poaceae) in tailing and its potential to increase the growth of maize (Zea mays)
Authors: SUHARNO SUHARNO , SOETARTO ENDANG SUTARININGSIH , SANCAYANINGSIH RETNO PENI , KASIAMDARI RINA SRI 
Published: March 2017

Abstract. Suharno, Soetarto ES, Sancayaningsih RP, Kasiamdari RS.2017. Association of arbuscular mycorrhizal fungi (AMF) with Brachiaria precumbens (Poaceae) in tailing and its potential to increase the growth of maize (Zea mays).Biodiversitas 18: 433-441.The role of Arbuscular Mycorrhizal Fungi (AMF) in the process of rehabilitation of degraded land is very important, including the handling of sand tailings. In the rehabilitation process, utilizing the AMF isolates from the tailings area will be easier to adapt to the habitat that will be rehabilitated. The purpose of this study was to determine AMF that associated with Brachiaria precumbens (Poaceae) derived from the tailings area in Timika, Papua, and its potential to the growth of maize (Zea mays). The methods used to determine the presence of AMF were a survey and wet sieving methods, while the calculation of percent colonization was done by slide method. The compatibility test and effectiveness of AMF inoculation on the maize growth were conducted by completely randomized design (CRD) with 4 treatments: M0: control (without mycorrhiza); M1: Clariodeoglomus etunicatum BGR; M2: C. lamellosum L1A01S; M3: C. etunicatum L3A12D each with eight replications. The results showed that the presence of the AMF in the rhizosphere of B. precumbens was found in the tailings deposition area Modified Ajkwa Deposition Area (ModADA) of a gold mine in Timika. AMF percent colonization at the root reached 73.3%, while the number of spores in the rhizosphere was 8-25 per 10 g samples of soil and increased to reach an average of 49.6 spores per 10 g soil samples by trap methods. Based on the morphological identification, AMF found in the B. precumbens rhizosphere were identified as genus Glomus, Scutellospora, Acaulospora, and Claroideoglomus, whereas based on molecular identification, two isolates (L1A01S and L3A12D) were identified as C. lamellosum L1A01S and C. etunicatum L1A12D. The compatibility test showed that the AMF was able to increase the growth of maize, and significantly affected plant height, leaf area, and relative growth rate. C. lamellosum L1A01S derived from the tailings had a better effect than C. etunicatum L3A12D and C. etunicatum BGR.
Keywords: Arbuscular Mycorrhizal Fungi, Brachiaria precumbens, tailings, Timika, Zea mays
Seasonal variations in abundance and diversity of copepods in Mond River estuary, Bushehr, Persian Gulf
Authors: HEDAYATI ALIAKBAR , POULADI MOJTABA , VAZIRIZADEH AMIR , QADERMARZI AMIR , MEHDIPOUR NEDA 
Published: March 2017

Abstract. Hedayati A, Pouladi M, Vazirizadeh A, QadermarziA, Mehdipour N. 2017. Seasonal variations in abundance and diversity of copepods in Mond River estuary, Bushehr, Persian Gulf. Biodiversitas 18: 447-452. The present study was carried out to investigate the abundance and biodiversity of copepods from Mond River (MR) estuary, Bushehr, Persian Gulf during 4 seasons and their relationships with environmental factors. The water samples were collected in mid-season from spring 2012 to winter 2013 for one year period. Copepod samples were collected by using of 140 Âµm plankton net with 25 cm mouth diameter and vertical towing in all stations. Copepod assemblages were comprised of 4 orders, 13 families and 10 genera. Orders were included; Calanoida, Cyclopoida, Poecilostomatoida, Harpacticoida and Genera were included: Cathocalanus, Acrocalanus, Paracalanus, Subeucalanus, Centropages, Temora, Calanopia, Labidocera, Pontella, Acartia, Oithona, Oncaea, Corycaeus, Microsetella, Microsetella and Euterpina. The order Calanoida with 10 genera was the most diverse and dominant order between Identified orders. The means (Â±SE) of copepods abundance were recorded in spring (5853.4Â±1826.19 Individual m-3), in summer (6707.6Â±1930.15 Ind. m-3), in fall (4393.6Â±1263.37 Ind. m-3) and in winter (3400Â±763.98 Ind. m-3), respectively. Simpson and Shannon-Wiener biodiversity indices were obtained in spring (0.87Â±0.11 and 2.86Â±0.19), in summer (0.89Â±0.006 and 3.11Â±0.15), in fall (0.86Â±0.13 and 2.66Â±0.2) and in winter (0.83Â±0.12 and 2.39Â±0.15), respectively. The copepod assemblages had most amounts of diversity and abundance at station 5 in all seasons. Pearson correlation showed significant correlation between copepod diversity and abundance with salinity, pH and temperature. Results showed that salinity factor was more effective environmental factor on Simpson (0.01> P and r=0.783) and Shannon-Weiner indices (0.01> P and r=0.727), and copepods abundance (0.01> P and r=0.664) in MR estuary.
Keywords: Abundance, copepod, diversity, environmental factor, Mond Estuary