bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of erectile dysfunction induced by aging: A comprehensive review
Authors: Zhuang Baojun , Zhuang Chenglin , Jiang Yongze , Zhang Jingyi , Zhang Yandong , Zhang Peihai , Yu Xujun , Xu Suyun 
Published: October 2024

AbstractBackgroundWith the increasing trend ofpopulation aging, erectile dysfunction (ED) among elderly men has emerged as apressing health concern. Despite extensive research on the relationship betweenED and aging, ongoing discoveries and evidence continue to arise.ObjectiveThrough this comprehensiveanalysis, we aim to provide a more nuanced theoretical framework for thedevelopment of preventive and therapeutic strategies for senile ED, ultimatelyenhancing the quality of life for elderly men.MethodsThis review delves deeper into thecore mechanisms underlying ED in the context of aging and offers acomprehensive overview of published meta‐analyses and systematic reviewspertinent to these conditions.Results and conclusionOur findings revealthat local structural damage to the penis, vascular dysfunction, neuronalinjury, hormonal alterations, other physiological changes, and psychologicalbarriers all play pivotal roles in the pathogenesis of aging‐related ED.Furthermore, more than 20 diseases closely associated with aging have beenimplicated in the occurrence of ED, further compounding the complexity of thisissue.
Comprehensive population pharmacokinetic modelling of sugemalimab, an anti‐programmed death‐ligand 1 (PD‐L1) human monoclonal antibody, in patients with solid tumours or lymphomas across multiple Phase I–III studies
Authors: Wang Kun , Pan Chaohsuan , Xu Fengyan , Tse Archie N. , Sheng Yucheng 
Published: October 2024

AimsThe aim of this study was to develop a population pharmacokinetics model for sugemalimab, a monoclonal antibody that targets programmed death‐ligand 1 (PD‐L1), using data from Phase I–III trials and to assess clinical factors affecting sugemalimab exposure.MethodsA nonlinear mixed‐effect modelling approach was employed to analyse pooled data from nine studies involving 1628 subjects to characterize the PopPK of sugemalimab. This investigation examined the influence of various covariates on sugemalimab pharmacokinetics (PK), encompassing demographics, baseline hepatic and renal function‐related covariates, and others (including anti‐drug antibody [ADA], combination treatment, Eastern Cooperative Oncology Group [ECOG] performance score, tumour burden and tumour type). Estimation accuracy and predictive ability of the final model were evaluated using various methods. The influence of covariates on sugemalimab exposure was assessed by simulation from the final model.ResultsA two‐compartment model with first‐order elimination and time‐varying clearance effectively described the PK of sugemalimab. Covariate analyses revealed significant relationships between sugemalimab clearance and body weight, albumin, gender, ADA, tumour burden and tumour type. The statistically significant covariates on central volume were body weight, albumin, gender and tumour type. No significant relationships were found in the final model for age, race, alanine aminotransferase, aspartate aminotransferase, creatinine, total bilirubin, alkaline phosphatase, combination treatment, creatinine clearance, ECOG, renal function or hepatic function. All significant covariates demonstrated less than a 20% effect on sugemalimab exposure.ConclusionsThe PopPK model adequately described the pharmacokinetic profile of sugemalimab with no clinically meaningful impact observed on its exposure across all covariates. Dose adjustment does not appear to be necessary.
Clinical research for saliva‐based therapeutic drug monitoring of linezolid
Authors: Inoue Yuki , Kashiwagi Hitoshi , Sato Yuki , Nashimoto Shunsuke , Endo Tsutomu , Takahata Masahiko , Komatsu Miki , Sugawara Mitsuru , Takekuma Yoh 
Published: October 2024

AimsLinezolid is primarily used to treat of methicillin‐resistant Staphylococcus aureus and multidrug‐resistant tuberculosis infections. Thrombocytopenia due to linezolid usage is a concern, and therapeutic drug monitoring has been reported to be effective in its prevention. Plasma concentrations provide valuable information for treatment decisions; however, collecting plasma samples can be burdensome for both patients and healthcare providers. Therefore, there is interest in saliva as an alternative for monitoring, considering its potential to replace plasma samples.MethodsPatients hospitalized at Hokkaido University Hospital and Hokkaido Spinal Cord Injury Center between April 2022 and July 2024, who received oral or intravenous linezolid treatment, were enrolled. The concentrations of linezolid were simultaneously measured in plasma and saliva samples. We determined the concentration profiles of linezolid in the saliva and examined the correlation between saliva and plasma linezolid concentrations.ResultsEighteen patients receiving linezolid were enrolled. The average of saliva/plasma (S/P) concentration ratios of linezolid were 1.018. A strong correlation was found between the salivary and plasma concentrations of linezolid (R = .833, P < .001). Notably, in patients receiving intravenous administration of linezolid, the correlation was even more pronounced (R = .885, P < .001). Additionally, when focusing on the S/P ratio of the trough concentrations in the morning and at night, the S/P ratios at night were much closer to 1.0.ConclusionThe concentrations of linezolid in plasma and saliva were similar, indicating their potential applicability in clinical settings. The monitoring of linezolid concentrations in saliva has been shown to be particularly suitable for patients receiving intravenous administration.
Improving CYP2C19 phenotyping using stereoselective omeprazole and 5‐hydroxy‐omeprazole metabolic ratios
Authors: Abouir Kenza , Varesio Emmanuel , Déglon Julien , Samer Caroline , Daali Youssef 
Published: October 2024

AbstractOmeprazole (OME) is a CYP2C19 phenotyping probe, marketed as a racemic (S)/(R) mixture or as an S‐enantiomer. Both CYP2C19 and CYP3A4 enzymes mediate (R)‐OME hydroxylation to (R)‐5‐hydroxyomeprazole, while (S)‐OME is exclusively hydroxylated via CYP2C19. This study investigates OME and its 5‐hydroxymetabolite enantiomers' pharmacokinetics using data from two studies involving healthy volunteers. In Study A, volunteers received OME alone in Session 1, OME combined with voriconazole and fluvoxamine in Session 2 and finally OME with rifampicin in Session 3. In Study B, volunteers received OME alone in Session 1, OME combined with voriconazole in Session 2 and finally OME with fluvoxamine in Session 3. Despite low metabolic ratio values of (S)‐OME, detectable modulation of CYP2C19 activity suggests both (R)‐ and (S)‐OME isomers could effectively assess CYP2C19 activity. Further research is needed for precise cut‐offs in different phenotype groups.
Quantitative Analysis of Myocardial Work in Gestational Diabetes Mellitus Using Noninvasive Left Ventricular Pressure‐Strain Loop Measurement
Authors: Zhang Jiaqi , Chang Caihong , Yu Changxiu , Peng Yao , Feng Wei , Song Juan , Wu Ji 
Published: October 2024

ABSTRACTBackgroundGestational diabetes mellitus (GDM) poses a risk for cardiovascular damage during pregnancy. This study focused on evaluating changes in left ventricular myocardial performance in GDM patients using the left ventricular pressure‐strain loop (LV‐PSL) method and examining risk factors associated with reduced myocardial function.MethodsA prospective, randomized study involving 112 pregnant women diagnosed with GDM was conducted from June 2021 to June 2024. Additionally, 84 healthy pregnant women from the same period served as the control group. Utilizing both conventional echocardiography and two‐dimensional speckle tracking echocardiography, left ventricular myocardial work metrics were assessed using LV‐PSL technology.ResultsGDM patients demonstrated significantly reduced values for global longitudinal strain (GLS), global work index (GWI), global work efficiency (GWE), and global constructive work (GCW) (p < 0.05), while conventional ultrasound measures showed no significant difference between GDM and control groups. GWI, GWE, GCW, and GLS had high predictive value for cardiac function changes in GDM patients, with GWE showing the highest predictive value {Area under curve (AUC) = 0.866, cutoff value = 95.5%, specificity = 0.77, sensitivity = 0.87}. GWI, GWE, and GCW were negatively correlated with GLS (r = −0.532, −0.411, −0.425, all p < 0.001), whereas global wasted work (GWW) showed a positive correlation with GLS (r = 0.325 and p < 0.001). These parameters were also correlated with HbA1c levels (r = −0.316, −0.256, −0.260, all p < 0.001 for negative correlations, and r = 0.172, p < 0.05 for positive correlations). Multivariate logistic regression indicated that 1‐h OGTT (mmol/L), 2‐h OGTT (mmol/L), and HbA1c (%) were significant predictors of left ventricular systolic function (GWE) in GDM patients.ConclusionsLV‐PSL is an effective tool for early detection of left ventricular systolic function impairment in GDM patients.
Emotion regulation as affective neoliberal governmentality
Authors: Smoliak Olga , Rice Carla , Rudder Deanna , Tseliou Eleftheria , LaMarre Andrea , LeCouteur Amanda , Gaete Joaquin , Davies Adam , Henshaw Sarah 
Published: October 2024

AbstractEmotion regulation is central in many therapy models, including couple and family therapy models. This article draws on poststructuralist governmentality studies and processual affect theory to offer insight into how the therapeutic concept of emotion regulation may reflect and support neoliberal affective forms of self‐governance. We suggest that couple and family therapy—through using professional discourses and affect‐oriented techniques or interventions—may be another site wherein neoliberal governmentality is implemented and extended in contemporary westernized neoliberalized societies. In facilitating emotion regulation, we argue that there is a risk that therapists may implicitly promote a neoliberal worldview that encourages clients to mobilize neoliberal techniques to become self‐improving, entrepreneurial subjects, responsible for their happiness and well‐being. Conditions of precarity associated with individualist, neoliberal capitalist ideologies and policies (e.g., unemployment, job insecurity, forced migration, wealth inequalities, mass incarceration, social isolation) generate emotional burdens for people to manage that professional techniques or interventions may normalize as clients' self‐management tasks. We theorize emotion regulation as an affective governmentality tactic of power and suggest that couple and family therapy can offer points of resistance to individualization and responsibilization and opportunities for creating or affirming alternative subjectivities and affectivities.
Analysis of Environmental Projects Financed by Fisheries Local Action Groups (FLAGs) in Spain During the Period of the European Maritime and Fisheries Fund (EMFF)
Authors: Miret‐Pastor Lluís , Herrera‐Racionero Paloma , Ortuño Miriam , Molina‐García Agustín 
Published: October 2024

ABSTRACTHundreds of Fisheries Local Action Groups (FLAGs) have emerged along the European Union coast trying to dynamize fisheries‐dependent areas through an approach based on community‐led local development (CLLD) strategies. In this research, we characterized and analyzed environmental projects funded by the FLAGs through the European Maritime and Fisheries Fund in Spain from 2014 to 2020. The Spanish Network of Fisheries Groups database allowed us to locate projects defined as environmental, which were then classified into six areas and different project typologies. Most projects were categorized by FLAGs as environmental but were really linked to tourism development. Moreover, true environmental projects were substantially lower in total cost than statistics showed. These conclusions should lead to a reflection on the role that FLAGs and European fisheries funds should play in environmental care of European coasts.
“Those feminists haven't come to us, they don't know our reality”: Indian sex workers' narratives of love and power
Authors: Cornwall Andrea , Majumdar Sutapa 
Published: October 2024

AbstractBased on a collaborative project with the Sex Workers' Freedom from Injustice Collective (Veshya Anyay Mukti Parishad, otherwise known as “VAMP”) in Maharashtra, India, this article explores sex workers’ narratives on love, life, power and freedom. Sex workers’ own accounts of the joys and difficulties they face in their intimate lives, in and outside work, we suggest here, offer important insights into the way in which they navigate patriarchy and throw fresh light on the questions of power and choice that have been so much at the heart of the sex work/prostitution debate.
Determinants of Peer Review Acceptance: Motivational Insights From German Academia
Authors: Lauer Sabine , Wilkesmann Uwe 
Published: October 2024

ABSTRACTThis article examines how motivation affects peer review acceptance of journal manuscripts among German professors of biology, business administration, mechanical engineering, and sociology. Data collected via an online survey (March–May 2022) tested hypotheses based on self‐determination theory. The results show significant discipline‐specific differences. In the soft disciplines, intrinsic motivation, own manuscript submissions (reciprocity), and external motivation positively influenced peer review acceptance, while the motive to discover something new had a negative effect. In the hard disciplines, only sense of obligation to the scientific community was significant. Staff support positively influenced peer review acceptance in soft disciplines. The control variables revealed that the total number of peer review requests was positively related to acceptance. However, age, gender, departmental budget linked to publications, and academic discipline were not significant factors. These findings deepen our understanding of motivational factors in peer review and highlight important disciplinary differences.
Reliability of the risk of bias assessment in randomized controlled trials for nursing: A cross‐sectional study
Authors: Yao Yi , Li Nian , Li Jieling , Feng Jia , Ma Jingxin , Liao Xiaoyang , Zhang Yonggang 
Published: October 2024

AbstractAimTo evaluate the percentage and reasons for disagreements in the risk of bias (RoB) assessments for randomized controlled trials (RCTs) included in more than one Cochrane review in the field of nursing.BackgroundDisagreement in RoB assessments reduces the credibility of the evidence summarized by systematic reviews (SRs). There is no study that evaluates the reliability of RoB assessments in nursing studies.DesignSecondary data analysis based on research reports.MethodsRCTs included in more than one review in the nursing have been included. The disagreement of the assessment was analysed, and the possible reasons for disagreements were investigated.ResultsTwenty‐three RCTs were included in more than one review. The agreement of assessment ranged from 36.84% for “selective reporting” to 91.30% for “random sequence generation”. “Allocation concealment” showed the optimal agreement (84.21%). The items “blinding of participants and personnel”, “blinding of outcome assessment” and “incomplete outcome data” showed poor agreement, with 50.00%, 58.82% and 66.67%, respectively. Most disagreements came from extracting incomplete or different RCTs' information.ConclusionsThe level of agreement of the assessment between reviews has varied greatly in the field of nursing. More complete and accurate information of RCTs needs to be collected when conducting a SR.
Advanced Monte Carlo method for simulating glass alteration: Application to aluminoborosilicate glasses
Authors: Delaye Jean‐Marc , Tiwari Sumit , Brun Emeric , Fossati Paul C. M. , Gin Stéphane 
Published: October 2024

AbstractUnderstanding the alteration mechanisms of nuclear glasses is paramount for safety assessment of deep geological disposal of nuclear waste. This endeavor poses significant challenges due to the experimental limitations in observing atomic‐scale mechanisms, which are essential for developing macroscopic alteration models. Consequently, a novel Monte Carlo approach has been developed to simulate the alteration process of simplified nuclear glasses at the atomic level. This approach employs a dual lattice to represent both the solid material and the solution, thereby facilitating the incorporation of diffusion and hydrolysis–recondensation mechanisms. Preliminary findings underscore the critical influence of alteration conditions on glass behavior and elucidate the interplay between rate of hydrolysis at the gel–solution interface and the morphology of the outer layer formed within the gel. Intense hydrolysis promotes the formation of a porous, low‐density layer, whereas slower hydrolysis fosters the development of a dense, cross‐linked layer.
High‐entropy ceramics with excellent energy storage performance via screening sintering aids
Authors: Ning Yating , Pu Yongping , Chen Zhemin , Sun Zixiong , Wu Chunhui , Lu Xiang , Shang Jing , Zhang Lei , Wang Bo , Li Xin 
Published: October 2024

AbstractHigh‐entropy perovskite ceramics have garnered widespread attention in the energy storage field due to their diversified composition and superior performance. However, the preparation of high‐performance high‐entropy ceramic materials still faces many challenges due to their complex composition and structure. This work systematically studies the effects of MgO, SiO2, Li2CO3, and MnCO3 on the sintering temperature and energy storage performance of (Na0.2Bi0.2Ba0.2Sr0.2Ca0.2)TiO3 (NBBSCT) high‐entropy ceramics. The introduction of MnCO3 successfully reduced the sintering temperature of the high‐entropy ceramics to 1150°C and achieved a high energy storage efficiency of 95.5% with this composition. The NBBSCT ceramics with 0.5 wt%MgO exhibited a breakdown field of 300 kV/cm and an energy storage density of 3.7 J/cm3. The study indicates that adding appropriate sintering aids can significantly improve the sintering behavior and energy storage performance of high‐entropy ceramics. This method provides new insights into the preparation and performance enhancement of high‐entropy energy storage ceramics.
Pulsed Light Decontamination of Red Chilies (Capsicum annuum var. longum)
Authors: Pravallika Kosana , Chakraborty Snehasis 
Published: October 2024

ABSTRACTThe impact of pulsed light treatment (PLT) on natural microbiota and inoculated microbes such as Salmonella Typhimurium, Bacillus cereus, and Aspergillus flavus on red chilies was investigated. Sequential drying did not completely inactivate the aerobic mesophiles and yeast and mold count. Hence, PLT (0.53–2.59 J cm−2) was employed as a decontamination technology on red chilies. PLT resulted in 8 log reduction of inoculated microorganisms on chilies at 2.59 J cm−2. The microbial inactivation kinetics followed Weibull distribution (R2 > 0.97) with β value of 1.1, 1.2, and 1.5 for S. Typhimurium, B. cereus, and A. flavus, respectively. Changes in structure and composition of cell components were identified by SEM and FTIR analysis. After PLT, phenolics, antioxidants, flavonoids, and capsaicinoids were better retained but a significant change in ascorbic acid and carotenoid's content was observed. Hence, PL can be a potential technology for decontamination of fresh and dried chilies along with maximum retention of bioactives.
Pyridoxal‐5′‐phosphate: A cost‐effective treatment candidate for hypertensive patients?
Authors: Lellig Michaela , Rodríguez Mariano , López‐Baltanás Rodrigo , Hermann Juliane , Wollenhaupt Julia , Noels Heidi , Zidek Walter , Tepel Martin , Mahfoud Felix , Jankowski Joachim , Muñoz‐Castañeda Juan R. , Jankowski Vera 
Published: October 2024

AbstractObjectivesBecause angiotensin (Ang) II is an essential vasoconstrictive peptide, we analyzed the impact of its post‐translational modification to pyruvamide–Ang II (Ang P) by pyridoxal‐5′‐phosphate (PLP) on blood pressure. PLP is a less expensive vitamin B6 derivative and, therefore, could be a cost‐effective drug against hypertension.MethodsEffect of Ang P on calcium ion entry into vascular smooth muscle cells (VSMCs) was analyzed. Binding affinity of Ang P to angiotensin II type 1 receptor (AT1R) was measured. Vasoconstrictive effect of Ang P was investigated using the bioassay of isolated perfused rat kidneys. Spontaneously hypertensive rats (SHR) were administered PLP. Additionally, Wistar Kyoto rats (WKY) received Ang II and PLP. Blood pressure was measured time‐dependently.ResultsAng II, incubated with PLP, was post‐translationally modified to Ang P. Calcium ion entry in VSMCs was significantly lower with Ang P compared to Ang II. Binding affinity of Ang P to AT1R was lower compared to Ang II. Perfusion pressure of isolated perfused rat kidneys increased less by Ang P than by Ang II. Blood pressure of SHR treated with PLP decreased significantly. Blood pressure of WKY rats treated with Ang II was increased to hypertensive values, whereas blood pressure of WKY rats cotreated with Ang II and PLP was not.ConclusionPLP induces a post‐translational modification of Ang II decreasing blood pressure in rats. Assuming that increased PLP intake in the form of vitamin B6 might reduce blood pressure in hypertensive patients, PLP might be a cost‐effective drug against hypertension.
Characteristics of children and adolescents with recurrent mental health emergency visits and clinicians' intervention tendencies
Authors: Karakus Oguz Bilal , Gamli Ipek Suzer , Yasoz Cemre , Yildirim Irem , Adak Ibrahim 
Published: October 2024

AimMental disorders affect approximately 15%–20% of childhood. However, due to various factors, these individuals do not benefit sufficiently from mental health services. Therefore, psychiatry emergency services become a key system in the need of psychiatric care for these children. This study aims to reveal the factors that predict recurrent admissions in children and adolescents admitted to the emergency department of a psychiatric hospital and the tendencies of clinicians during management.MethodsIn our study, the data of patients aged 0–18 years who applied to the emergency department between 1 March 2022 and 01 March 2023 were scanned retrospectively. Participants who applied once were included in the ‘single applicant’ group, whereas patients who applied two or more times were included in the ‘repeated applicants’ group.ResultsA total of 1563 emergency applications were recorded by 785 different patients. A total of 62.2% of the patients visited the emergency department once, while 37.8% applied two or more times. Non‐suicidal self‐injury, delusion/hallucination, irritability and depression were significantly higher in recurrent applicants (P < 0.05). Psychotic disorder, bipolar disorder, major depression and borderline personality traits were significantly frequent in these patients (P < 0.05). Additionally, it was determined that the number of psychiatric diagnoses, referral time, need for chemical restraint, having a diagnosis of psychotic disorder or borderline personality traits increased the likelihood of recurrence.ConclusionsOur results indicate some special risk factors that increase the likelihood of recurrent emergency admissions in children and adolescents. Further research with larger sample sizes may elucidate the unique needs of these children in order to use of community resources beneficially.