bluuebunny/crossref_metadata_2025_split huggingface dataset:
New giant radio sources and underluminous radio halos in two galaxy clusters
Authors: Cuciti V. , Brunetti G. , van Weeren R. , Bonafede A. , Dallacasa D. , Cassano R. , Venturi T. , Kale R. 
Published: September 2017

Aims. The aim of this work is to analyse the radio properties of the massive and dynamically disturbed clusters Abell 1451 and Zwcl 0634.1+4750, especially focusing on the possible presence of diffuse emission.
Methods. We present new Giant Metrewave Radio Telescope (GMRT) 320 MHz and Jansky Very Large Array (JVLA) 1.5 GHz observations of these two clusters.
Results. We found that both Abell 1451 and Zwcl 0634.1+4750 host a radio halo with a typical spectrum (α ~ 1−1.3). Similarly to a few other cases reported in the recent literature, these radio halos are significantly fainter in radio luminosity with respect to the current radio power-mass correlations and they are smaller than classical giant radio halos. These underluminous sources might contribute to elucidating the complex mechanisms of formation and evolution of radio halos. Furthermore, we detected a candidate radio relic at large distance from the cluster centre in Abell 1451 and a peculiar head-tail (HT) radio galaxy in Zwcl 0634.1+4750, which might be interacting with a shock front.
Cosmic flow around local massive galaxies
Authors: Kashibadze Olga G. , Karachentsev Igor D. 
Published: September 2017

Aims. We use accurate data on distances and radial velocities of galaxies around the Local Group, as well as around 14 other massive nearby groups, to estimate their radius of the zero-velocity surface, R0, which separates any group against the global cosmic expansion.
Methods. Our R0 estimate was based on fitting the data to the velocity field expected from the spherical infall model, including effects of the cosmological constant. The reported uncertainties were derived by a Monte Carlo simulation.
Results. Testing various assumptions about a location of the group barycentre, we found the optimal estimates of the radius to be 0.91 ± 0.05 Mpc for the Local Group, and 0.93 ± 0.02 Mpc for a synthetic group stacked from 14 other groups in the Local Volume. Under the standard Planck model parameters, these quantities correspond to the total mass of the group ~ (1.6 ± 0.2) × 1012M⊙. Thus, we are faced with the paradoxical result that the total mass estimate on the scale of R0 ≈ (3−4)Rvir is only 60% of the virial mass estimate. Anyway, we conclude that wide outskirts of the nearby groups do not contain a large amount of hidden mass outside their virial radius.
Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis
Authors: Moore Bradley 
Published: September 2017

Meroterpenoid natural products are important bioactive molecules with broad distribution throughout nature. In Streptomyces bacteria, naphthoquinone-based meroterpenoids comprise a simple yet structurally fascinating group of natural product antibiotics that are enzymatically constructed through a series of asymmetric alkene and arene halofunctionalization reactions. This account article highlights our discovery and characterization of a group of vanadium-dependent chloroperoxidase enzymes that catalyze halogen-assisted cyclization and rearrangement reactions and have inspired biomimetic syntheses of numerous meroterpenoid natural products.1	Introduction2	Early Biosynthetic Insights and the Characterization of Alkene Halofunctionalization in Napyradiomycin Biosynthesis3	Discovery of the Merochlorin Natural Products and Enzymatic Aryl Halofunctionalization4	Discovery and Development of Unifying THN-Based Meroterpenoid Biosynthesis and Synthesis Approaches5	Insights into Naphterpin and Marinone Biosynthesis Involving Cryptic Aryl Halofunctionalization Reactions6	Closing Thoughts
Magnified endoscopic observation of small depressed gastric lesions using linked color imaging with indigo carmine dye
Authors: Kitagawa Yoshiyasu , Hara Taro , Ikebe Dai , Nankinzan Rino , Takashiro Hideyuki , Kobayashi Ryosuke , Nakamura Kazuyoshi , Yamaguchi Taketo , Suzuki Takuto 
Published: September 2017

Abstract
Background and study aims Magnifying linked color imaging with indigo carmine dye (M-Chromo-LCI) enables sterically enhanced and color image-magnified observation of the superficial gastric mucosa. This study investigated the usefulness of M-Chromo-LCI for the differential diagnosis of gastric lesions.
Patients and methods 100 consecutive small depressed lesions were examined with conventional white-light imaging (C-WLI), magnifying blue-laser imaging (M-BLI), and M-Chromo-LCI. Endoscopic images were reviewed by three experts and three non-experts. Diagnostic accuracy and interobserver agreement were compared among the modalities.
Results For experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (82.7 % vs. 67.0 %; P < 0.001). The diagnostic accuracy of M-Chromo-LCI was not different from M-BLI (87.7 % vs. 82.7 %; P = 0.31). For non-experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (69.3 % vs. 52.3 %; P < 0.001). M-Chromo-LCI additionally showed a significantly higher diagnostic accuracy than M-BLI (79.7 % vs. 69.3 %; P = 0.005). M-Chromo-LCI had the highest interobserver agreement for each group.
Conclusions: M-Chromo-LCI is expected to become a useful modality for the accurate diagnosis of gastric lesions.
Double incision and snare resection in symptomatic Zenker’s diverticulum: a modification of the stag beetle knife technique
Authors: Gölder Stefan , Brueckner Juliane , Ebigbo Alanna , Messmann Helmut 
Published: September 2017

Abstract
Background and study aim Relief from dysphagia and regurgitation are the main goals of therapy in symptomatic Zenker’s diverticulum. Flexible endoscopic treatment has proved to be an effective and safe method in control of these symptoms. The aim of our study was to further improve the resection of the cricopharyngeal muscle using a new technique, the double incision and snare resection (DISR) procedure, to reduce the recurrence rate.
Patients and methods From February 2016 to April 2017, 16 patients were treated with 18 DISR procedures at our institution. The symptoms of the patients were recorded by a seven-item questionnaire prior to treatment, and re-evaluation was scheduled at 1 and 6 months after treatment.
Results The median age was 70 years (range 55 – 85), and 10 patients were men (62 %). The median size of the diverticulum was 20 mm (range 5 – 40 mm), and the DISR procedure was performed in 28 minutes (range 20 – 47 minutes), with no major postinterventional complications. All patients re-started oral nutrition on the day after the intervention; a gastric tube was not required. The median follow-up was 3 months (range 1 – 15 months). Two patients received a planned second-step procedure, one because of a very large cricopharyngeal muscle and one because of a cyst inside the Zenker’s bridge. Although one patient suffered from mild recurrence of symptoms, she refused a second treatment. All other patients were free of symptoms after treatment.
Conclusions The DISR procedure is a new endoscopic treatment technique that safely and reproducibly offers relief from symptomatic Zenker’s diverticulum.
Defining Italianness: Poetry, Music and the Construction of National Identity in Nineteenth- and Twentieth-Century Accounts of the Medieval Italian Lyric Tradition
Authors: Jennings Lauren 
Published: September 2017

ABSTRACTThis article explores the role of music in nineteenth- and twentieth-century accounts of medieval Italian literature and its relation to the construction of Italian national identity both during and long after the Risorgimento. Tracing music's role in the writings of Giosuè Carducci, Vincenzo De Bartholomaeis and Aurelio Roncaglia, it argues that music somewhat paradoxically became entangled with Italy's literary identity even as scholars worked to extricate the peninsula's most renowned poetry from its grasp. In the realm of ‘popular’ poetry, Italianness depends on the presence of music, which serves as a marker of that poetry's popular origins. In contrast, music's absence from the realm of ‘high-art’ poetry was essential to the construction of an Italian tradition independent of and superior to its French and Provençal predecessors.
The Nursery as Circus: Dancing the Childlike to Fauré's Dolly Suite, 1913
Authors: Coombes Timothy F. 
Published: September 2017

ABSTRACTIn 1913, at the Théâtre des Arts in Paris, a controversial but highly successful ballet choreographed a circus-style pantomime to the music of Fauré's Dolly Suite. With its apparently incongruent relation of dance to music, the ballet displayed, as one reviewer put it, ‘criticisms in action’. This article investigates how we might conceive the production as an act of musical and cultural criticism, by examining its close relation with contexts such as early comic film, music-hall entertainment, the children's literature market, medical and anthropological theories, and surrealist thought. The ballet implicitly challenged conventional interpretations of Fauré's music as reflecting a particular perception of childhood – one which was rather too close to the sentimental attitudes vehemently dismissed in contemporaneous literature. The production was an important manifestation of an emergent understanding of the ‘childlike’ in early twentieth-century French culture – as a condition enlightened by irrationality, with important physiological traits.
Technology, Listening and Historical Method: Placing Audio in the Post-War British Home
Authors: Perchard Tom 
Published: September 2017

ABSTRACTThis article explores the ways in which audio in the home was figured in (and helped shape) changing consumer and gender roles in post-war Britain. It looks at the ways in which innovations in home-furnishing and audio-equipment design and manufacture created an environment with new tactile as well as sonic qualities; it examines the ways in which changing music styles helped develop new markets for audio equipment and new meanings for audio discourse. But before it does so, the article sets out some arguments on cultural-historical method. Extant academic writing on post-war home audio tends to privilege the study of media representation – and the critique of ideology constructed therein – at the expense of other kinds of enquiry and source-work. In making use of a broader range of sources and interpretative approaches, this piece aims for a thick reading of the ‘social’ along with the ‘cultural’.
Induction of plant disease resistance upon treatment with yeast cell wall extract
Authors: Yaguchi Takaomi , Kinami Tomohisa , Ishida Tetsuya , Yasuhara Takaomi , Takahashi Kosaku , Matsuura Hideyuki 
Published: September 2017

Abstract
It has been reported that treatment with yeast cell wall extract (YCWE) induces PDF1 and PR-1 gene expression; these transcripts are important markers of plant disease resistance, though the detailed signaling mechanisms that induce these defense responses are still unknown. In this report, we found that YCWE treatment triggered rice cell suspension cultures to accumulate phenylalanine (Phe), cis-12-oxo-phytodienoic acid (OPDA), 12-hydroxyjasmonoyle isoleucine (12OHJA-Ile), and azelaic acid (AzA). YCWE treatment also reduced endogenous triacylglycerol (TG) content. The addition of 13C-uniform-labeled oleic, linoleic and linolenic acids to the rice cell suspension cultures gave rise to 13C-uniform-labeled AzA. It was also found that YCWE treatment for Arabidopsis thaliana resulted in accumulations of OPDA, AzA, Phe, and camalexin together with enhanced resistance against Botrytis cinerea infection. This suggested that YCWE treatment upon plants may activate JA and AzA signaling systems to induce plant disease resistance.
Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane
Authors: Menck Kerstin , Sönmezer Can , Worst Thomas Stefan , Schulz Matthias , Dihazi Gry Helene , Streit Frank , Erdmann Gerrit , Kling Simon , Boutros Michael , Binder Claudia , Gross Julia Christina 
Published: September 2017

ABSTRACTExtracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin. Using differential centrifugation EVs pelleting at 14,000 g (“microvesicles” (MV)) and 100,000 g (“exosomes”) are distinguishable by protein markers. Neutral sphingomyelinase (nSMase) inhibition has been shown to inhibit exosome release from cells and has since been used to study their functional implications. How nSMases (also known as SMPD2 and SMPD3) affect the basal secretion of MVs is unclear. Here we investigated how SMPD2/3 impact both EV populations. SMPD2/3 inhibition by GW4869 or RNAi decreases secretion of exosomes, but also increases secretion of MVs from the plasma membrane. Both populations differ significantly in metabolite composition and Wnt proteins are specifically loaded onto MVs under these conditions. Taken together, our data reveal a novel regulatory function of SMPD2/3 in vesicle budding from the plasma membrane and clearly suggest that – despite the different vesicle biogenesis – the routes of vesicular export are adaptable.
On Gevrey vectors of L. Hörmander’s operators
Authors: Derridj Makhlouf 
Published: September 2017

We study the regularity of Gevrey vectors of L. Hörmander’s operators:

P
=

∑

j
=
1

m

X
j
2

+

X
0

+
c
,

\begin{equation*} P=\sum _{j=1}^{m} X_j^2+X_0+c, \end{equation*}

where

X
0

X_0

,

X
1

X_1

, …,

X
m

X_m

are real vector fields in an open set

Ω
⊂

R

n

\Omega \subset \mathbb {R}^n

and

c
c

is a smooth function. More precisely, we prove the following: If the coefficients of

P
P

are in the Gevrey class

G
k

(
Ω
)

G^k(\Omega )

,

k
∈

N

k\in \mathbb N

,

k
≥
1

k\geq 1

, and

P
P

satisfies the following estimate with

p

/

q

p/q

rational,

0
>
p
≤
q

0>p\leq q

:

|

|

v

|

|

p

/

q

2

≤
C
(

|

(
P
v
,
v
)

|

+

|

|

v

|

|

2

)
,

∀
v
∈

D

(

Ω
0

)
,

\begin{eqnarray} ||v ||^2_{p/q}\leq C(|(Pv,v)|+||v ||^2), \; \forall v \in \mathcal D(\Omega _0), \end{eqnarray}

for some open subset

Ω
0

⊂

Ω
0

¯

⊂
Ω

\Omega _0\subset \overline {\Omega _0}\subset \Omega

, then

G
k

(
P
,

Ω
0

)
⊂

G

k

q
p

(

Ω
0

)

G^k(P, \Omega _0)\subset G^{k\frac {q}{p}}(\Omega _0)

. This provides in particular a local version of a recent result of N. Braun Rodrigues, G Chinni, P. D. Cordaro, and M. R. Jahnke, giving a global such result, with

k
≥
1

k\geq 1

not necessarily integer, for Hörmander’s operators on a torus.
Metabolic Syndrome Induces Over Expression of the Human AT1R: A Haplotype-Dependent Effect With Implications on Cardio-Renal Function
Authors: Jain Sudhir , Puri Nitin , Rana Anita , Sirianni Natalie , Mopidevi Brahmaraju , Kumar Ashok 
Published: September 2017

Abstract

BACKGROUND
The transcriptional regulation of the human angiotensin receptor subtype 1 (AT1R) gene in pathophysiologies, like the metabolic syndrome, is poorly understood. The human AT1R gene has polymorphisms in its promoter that can be arranged in 2 haplotypes. Variants -810T, -713T, -214A, and -153A always occur together (Hap-I) and variants -810A, -713G, -214C, and -153G form Hap-II. We have hypothesized that high fat diet will alter cellular transcriptional milieu and increase hAT1R gene expression in a haplotype-dependent manner. This will set up an AT1R-mediated feed-forward loop promoting inflammation, oxidative stress, and hypertension in Hap-I mice.

METHOD
Since Hap-I of the human AT1R gene is associated with hypertension in Caucasians, we generated transgenic (TG) mice with Hap-I and Hap-II and studied the physiological significance of high fat diet (HFD) on haplotype specific gene expression. Animals were fed with HFD for 20 weeks followed by blood pressure (BP) analysis and collection of their tissues for molecular and biochemical studies.

RESULTS
After HFD treatment, as compared to Hap-II, TG mice with Hap-I show increased expression of hAT1R gene and higher BP; suppression of antioxidant defenses (HO1, SOD1) and increased expression of IL-6, TNFα, IL-1β, NOX1. In vivo ChIP assay has shown that transcription factors CEBPβ, STAT3, and USF bind more strongly to the chromatin obtained from Hap-I TG mice.

CONCLUSIONS
Taken together, our results suggest, that after HFD treatment, as compared to Hap-II, the TG mice with Hap-I overexpress the AT1R gene due to the stronger transcriptional activity, thus resulting in an increase in their BP.
Identification of cancer driver genes in focal genomic aberrations from whole-exome sequencing data
Authors: Jang Ho , Lee Hyunju 
Published: September 2017

Abstract

Summary
Whole-exome sequencing (WES) data have been used for identifying copy number aberrations in cancer cells. Nonetheless, the use of WES is still challenging for identification of focal aberrant regions in multiple samples that may contain cancer driver genes. In this study, we developed a wavelet-based method for identifying focal genomic aberrant regions in the WES data from cancer cells (WIFA-X). When we applied WIFA-X to glioblastoma multiforme and lung adenocarcinoma datasets, WIFA-X outperformed other approaches on identifying cancer driver genes.

Availability and implementation
R source code is available at http://gcancer.org/wifax.

Supplementary information
Supplementary data are available at Bioinformatics online.
Tumor origin detection with tissue-specific miRNA and DNA methylation markers
Authors: Tang Wei , Wan Shixiang , Yang Zhen , Teschendorff Andrew E , Zou Quan 
Published: September 2017

Abstract

Motivation
A clear identification of the primary site of tumor is of great importance to the next targeted site-specific treatments and could efficiently improve patient‘s overall survival. Even though many classifiers based on gene expression had been proposed to predict the tumor primary, only a few studies focus on using DNA methylation (DNAm) profiles to develop classifiers, and none of them compares the performance of classifiers based on different profiles.

Results
We introduced novel selection strategies to identify highly tissue-specific CpG sites and then used the random forest approach to construct the classifiers to predict the origin of tumors. We also compared the prediction performance by applying similar strategy on miRNA expression profiles. Our analysis indicated that these classifiers had an accuracy of 96.05% (Maximum–Relevance–Maximum–Distance: 90.02–99.99%) or 95.31% (principal component analysis: 79.82–99.91%) on independent DNAm datasets, and an overall accuracy of 91.30% (range 79.33–98.74%) on independent miRNA test sets for predicting tumor origin. This suggests that our feature selection methods are very effective to identify tissue-specific biomarkers and the classifiers we developed can efficiently predict the origin of tumors. We also developed a user-friendly webserver that helps users to predict the tumor origin by uploading miRNA expression or DNAm profile of their interests.

Availability and implementation
The webserver, and relative data, code are accessible at http://server.malab.cn/MMCOP/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Less dementia with oral anticoagulation in atrial fibrillation
Authors: Friberg Leif , Rosenqvist Mårten 
Published: September 2017

Abstract

Aims
The association between atrial fibrillation (AF) and dementia is well documented, but it is not clear if oral anticoagulant treatment offers protection. The aim of the study is therefore to compare the incidence of new dementia in patients with AF with and without oral anticoagulants, and to explore if there is a difference between novel anticoagulants and warfarin in this respect.

Methods and results
Retrospective registry study of all patients with hospital diagnosis of AF and no previous diagnosis of dementia in Sweden between 2006 and 2014. Propensity score matching, falsification endpoints, and analyses according to intention to treat as well as on-treatment principles were used. The study included 444 106 patients and over 1.5 million years at risk. Patients on anticoagulant treatment at baseline was associated with 29% lower risk of dementia than patients without anticoagulant treatment [hazard ratio (HR) 0.71, 95% confidence intervals (95% CI) 0.68–0.74] and 48% lower risk analysed on treatment (HR 0.52, 95% CI 0.50–055). Direct comparison between new oral anticoagulants and warfarin showed no difference (HR 0.97, 95% CI 0.67–1.40).

Conclusion
The risk of dementia is higher without oral anticoagulant treatment in patients with AF. This suggests that early initiation of anticoagulant treatment in patients with AF could be of value in order to preserve cognitive function.
The origin of the LMC stellar bar: clues from the SFH of the bar and inner disc
Authors: Monteagudo L , Gallart C , Monelli M , Bernard E J , Stetson P B 
Published: September 2017

Abstract
We discuss the origin of the Large Magellanic Cloud (LMC) stellar bar by comparing the star formation histories (SFHs) obtained from deep colour–magnitude diagrams (CMDs) in the bar and in a number of fields in different directions within the inner disc. The CMDs, reaching the oldest main-sequence turn-offs in these very crowded fields, have been obtained with VIMOS on the Very Large Telescope in the service mode, under very good seeing conditions. We show that the SFHs of all fields share the same patterns, with consistent variations of the star formation rate as a function of time in all of them. We therefore conclude that no specific event of star formation can be identified with the formation of the LMC bar, which instead likely formed from a redistribution of disc material which occurred when the LMC disc became bar unstable, and shared a common SFH with the inner disc thereafter. The strong similarity between the SFH of the centre and edge of the bar rules out the expected significant spatial variations of the SFH across the bar.