bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated analysis of single cell transcriptomic data across conditions, technologies, and species
Authors: Butler Andrew , Satija Rahul 
Published: July 2017

ABSTRACTSingle cell RNA-seq (scRNA-seq) has emerged as a transformative tool to discover and define cellular phenotypes. While computational scRNA-seq methods are currently well suited for experiments representing a single condition, technology, or species, analyzing multiple datasets simultaneously raises new challenges. In particular, traditional analytical workflows struggle to align subpopulations that are present across datasets, limiting the possibility for integrated or comparative analysis. Here, we introduce a new computational strategy for scRNA-seq alignment, utilizing common sources of variation to identify shared subpopulations between datasets as part of our R toolkit Seurat. We demonstrate our approach by aligning scRNA-seq datasets of PBMCs under resting and stimulated conditions, hematopoietic progenitors sequenced across two profiling technologies, and pancreatic cell ‘atlases’ generated from human and mouse islets. In each case, we learn distinct or transitional cell states jointly across datasets, and can identify subpopulations that could not be detected by analyzing datasets independently. We anticipate that these methods will serve not only to correct for batch or technology-dependent effects, but also to facilitate general comparisons of scRNA-seq datasets, potentially deepening our understanding of how distinct cell states respond to perturbation, disease, and evolution.AvailabilityInstallation instructions, documentation, and tutorials are available athttp://www.satijalab.org/seurat
VolcanoR - web service to produce volcano plots and do basic enrichment analysis
Authors: Naumov Vladimir , Balashov Ivan , Lagutin Vadim , Borovikov Pavel , Alexeev Alexey 
Published: July 2017

AbstractSummary: We introduce VolcanoR - web based tool to analyse results of differential gene expression. It takes a table containing gene name p-value and foldChange as input data. It can produce publication quality volcano plots, apply different p-value and fold change thresholds and do basic GeneOntology and KEGG enrichment analysis with selected gene set. For now it supports H.sapiens, R.norvegicus and M.musclus.Availability and Implementation: VolcanoR is wtitten using R Shiny framework. It is publically available athttp://volcanor.bioinf.suor stand-alone application, that can be downloaded athttps://github.com/vovalive/volcanoRContact:looongdog@gmail.com
Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions
Authors: Demopoulos Carly , Kothare Hardik , Mizuiri Danielle , Henderson-Sabes Jennifer , Fregeau Brieana , Tjernagel Jennifer , Houde John , Sherr Elliott H. , Nagarajan Srikantan S. 
Published: July 2017

AbstractSpeech and motor deficits are highly prevalent (>70%) in individuals with the 600 kb BP4-BP5 16p11.2 deletion; however, the mechanisms that drive these deficits are unclear, limiting our ability to target interventions and advance treatment. This study examined fundamental aspects of speech motor control in participants with the 16p11.2 deletion. To assess capacity for control of voice, we examined how accurately and quickly subjects changed the pitch of their voice within a trial to correct for a transient perturbation of the pitch of their auditory feedback. When compared to sibling controls, 16p11.2 deletion carriers show an over-exaggerated pitch compensation response to unpredictable mid-vocalization pitch perturbations. We also examined sensorimotor adaptation of speech by assessing how subjects learned to adapt their sustained productions of formants (speech spectral peak frequencies important for vowel identity), in response to consistent changes in their auditory feedback during vowel production. Deletion carriers show reduced sensorimotor adaptation to sustained vowel identity changes in auditory feedback. These results together suggest that 16p11.2 deletion carriers have fundamental impairments in the basic mechanisms of speech motor control and these impairments may partially explain the deficits in speech and language in these individuals.
DrosophilaKruppel homolog 1 represses lipolysis through interaction with dFOXO
Authors: Kang Ping , Chang Kai , Liu Ying , Bouska Mark , Karashchuk Galina , Thakore Rachel , Zheng Wenjing , Post Stephanie , Brent Colin S. , Li Sheng , Tatar Marc , Bai Hua 
Published: July 2017

AbstractTranscriptional coordination is a vital process contributing to metabolic homeostasis. As one of the key nodes in the metabolic network, the forkhead transcription factor FOXO has been shown to interact with diverse transcription co-factors and integrate signals from multiple pathways to control metabolism, oxidative stress response, and cell cycle. Recently, insulin/FOXO signaling has been implicated in the regulation of insect development via the interaction with insect hormones, such as ecdysone and juvenile hormone. In this study, we identified an interaction between dFOXO and the zinc finger transcription factor Kruppel homolog 1 (Kr-h1), one of the key players in juvenile hormone signaling inDrosophila. We found thatKr-h1mutants have reduced triglyceride storage, decreased insulin signaling and delayed larval development. Notably, Kr-h1 physically and genetically interacts with dFOXOin vitroandin vivoto regulate the transcriptional activation of adipose lipasebrummer(bmm). The transcriptional co-regulation by Kr-h1 and dFOXO may represent a broad mechanism by which Kruppel-like factors integrate with insulin signaling to maintain metabolic homeostasis and coordinate organism growth.
Glass Ceiling and women employees in Asian organizations: a tri-decadal review
Authors: Lathabhavan Remya , Balasubramanian Senthil Arasu 
Published: July 2017

Purpose
The purpose of the paper is to review and analyse different glass ceiling studies conducted in different Asian countries during the three decades after the introduction of the metaphor. It also describes the antecedents and the consequences of the glass ceiling.

Design/methodology/approach
The method chosen for the study was a computerised search of available materials using the keywords relating to glass ceiling in Asia and latest reports from international organisations.

Findings
The perception of glass ceiling existence in Asian countries has been sorted out region-wise. Different factors for glass ceiling have been categorised under different theories.

Research limitations/implications
The study includes a multiregional aspect of glass ceiling, which will be useful for further studies in this area. The limitation of the study is that it did not assess the awareness and influence of glass ceiling in each industry.

Practical implications
Since the study showed glass ceiling practices in different countries in Asia, it might help policy makers for making proper decisions for breaking of glass ceiling.

Social implications
The study may be a part of empowering women as it analyses areas of inequality and finds out antecedents.

Originality/value
This paper is the first to shed light on glass ceiling on a multicultural and multiregional aspect.
The impact of within-country and within-firm factors on Japanese foreign subsidiary performance during economic crisis
Authors: Cordeiro Matheus Baldo , Ogasavara Mario Henrique , Masiero Gilmar 
Published: July 2017

PurposeThe purpose of this paper is to analyze the relevant aspects that influence foreign subsidiary’s performance and remain how they retain competitiveness in international markets during economic crisis. To investigate this effect, this research analyzes the behavior of Japanese subsidiaries located in European countries during the pre- and post-crisis periods that started in the USA in 2008 and spread all over the world.Design/methodology/approachThis is a quantitative study with an analysis based on longitudinal data of foreign subsidiaries of Japanese multinational firms during the period 2006-2013. It applies a multiple linear regression with panel data using fixed effects models.FindingsThe findings show that within-firm factors related to local experiential knowledge, market entry through joint ventures with partners from the same nationality, and subsidiary management with a team of expatriates all have a positive impact on subsidiary performance during times of economic crisis. Moreover, within-country factors involving macroeconomic aspects related to inflation rate and population income indicators show a negative impact on performance. Finally, the results confirm that subsidiary performance is higher in the pre-crisis period, showing the importance of considering economic crisis aspects in longitudinal studies.Practical implicationsThe result has implications for managers of multinational firms to understand which factors most impact the success of their foreign subsidiaries during times of economic crisis. In this way, managers can, with greater confidence, decide to reach the most important performance indicator in subsidiary management.Originality/valueThe majority of studies on economic crisis is based on an economic perspective and mostly investigates Asian and Argentinean crises. When considering a firm-level perspective, most research studies conducted on a subsidiary level are cross-sectional or use survival as a measure of performance. This paper applies a longitudinal study using subsidiary-level data and analyzes performance by sales and productivity measurement. In addition, it investigates whether or not within-country and within-firm factors impacted subsidiary performance during the 2008 economic crisis.
Attitudes toward GM foods, biotechnology R&D investment and lobbying activities among agribusiness firms in the food, feed, chemical and seed industries in China
Authors: Deng Haiyan , Hu Ruifa , Huang Jikun , Pray Carl , Jin Yanhong , Li Zhonghua 
Published: July 2017

Purpose
Economic interest groups such as seed, pesticide, feed, and food companies play an important role in supporting or preventing the production of genetically modified (GM) crops. The purpose of this paper is to examine firm managers’ attitudes toward GM technology, biotechnology R&D investment, and political lobbying activities.

Design/methodology/approach
Using data from surveys of 160 managers in the food, feed, chemical, and seed industries in 2013-2014, this paper employed three probit models to examine the determinants of managers’ attitudes, biotechnology R&D investment, and lobbying activities.

Findings
The results show that most Chinese agribusiness managers are concerned about GM foods and oppose its adoption. Nevertheless, one-third of the firms invest in biotechnology R&D and less than 15 percent of managers lobbied the government to change biotechnology policies. The econometric estimation results suggest that profit change expectation is the main factor affecting managers’ attitudes and biotechnology R&D investment decisions, whereas lobbying activities are significantly influenced by their attitudes and biotechnology R&D investment. In addition, managers’ attitudes toward GM foods also significantly influence firms’ decisions to invest in biotechnology R&D.

Originality/value
This paper has improved on previous research in two ways. First, it analyses the determinants of agribusiness firm managers’ attitudes toward GM technology, biotechnology R&D investment, and lobbying activities. Second, the methodology involves an analysis of agribusiness firm survey data in the food, feed, chemical, and seed industries, which is the first time to use such data to research on economic interest group in agricultural biotechnology field.
Effects of regulations and competition on the innovativeness-performance relationship
Authors: Anning-Dorson Thomas , Nyamekye Michael Boadi , Odoom Raphael 
Published: July 2017

PurposeThe purpose of this paper is to investigate the nature and the extent of moderation effect of the regulatory regime and competition, on the innovativeness-performance relationship among financial services firms. Based on the absorptive capacity theory, this study argues that firms must gather adequate knowledge from the external environment (specifically on regulatory systems and competitive landscape) to assist in developing competitive innovation strategies, and to realize the needed performance benefits from such strategies.Design/methodology/approachData were collected from the Ghana’s financial services sector with a focus on banking and insurance institutions. Structural equation modeling and regression models were specified to test both the direct effects of variables of interest, and the moderation effects of environmental factors on the independent and dependent variables.FindingsThe results of the study show that both process and product innovativeness enhance financial services firms’ performance. While competition was found to stifle innovativeness, regulatory regime was found to promote innovativeness in financial services. Regulatory regime was also found to positively moderate the relationship between process innovativeness and performance, while competition was found to positively moderate the relationship between product innovativeness and performance.Research limitations/implicationsThe firms sampled are from an emerging economy with a growing financial services sector, and as a result, the findings may not apply to contexts with different economic characteristics.Originality/valueThis study asserts that in enhancing innovativeness in the financial services markets, firms must recognize the value of new external information on regulatory regime and competition as key environmental factors. Financial service firms must assimilate, transform, and apply such new knowledge in their innovation efforts in order to improve performance. For firms to fully benefit from their innovation, process innovativeness must be aligned with regulatory systems while product innovation yields best returns in competitive periods.
Identifying the effects of perceived values of mobile banking applications on customers
Authors: Berraies Sarra , Ben Yahia Karim , Hannachi Mariem 
Published: July 2017

Purpose
The purpose of this paper is twofold: first, the authors empirically examine the effect of the perceived values of mobile banking (MB) applications on customers’ e-trust, e-satisfaction and e-loyalty and second, the authors investigate the moderating role of customers’ age in the relationship between perceived value of MB and e-trust.

Design/methodology/approach
A survey was conducted on a sample of 361 Tunisian banks’ customers using mobile applications. Structural equation modeling method was performed to test the research hypotheses.

Findings
The results of this research revealed that quality, price and emotional perceived values’ dimensions of MB applications are predictors of customers’ e-trust. Within this spectrum, age acts as a moderator in these latter relationships. Findings also suggested that e-trust has positive effects on e-satisfaction and e-loyalty.

Practical implications
This paper presented a reading grid for bank marketers allowing them to identify the levers they must focus their efforts on so as to retain the customers using MB applications. It also permits them to identify the needs and values of three generation of customers, namely baby boomers, generation X and generation Y, so that they can offer better services for each group.

Originality/value
This paper sheds light on an innovative and unexplored topic in the literature. The authors broaden understanding of the relationship between the perceived values of MB applications, e-loyalty, e-trust and e-satisfaction. Research devoted to investigate these different links through an integrative model does exist, yet embryonic. This study also highlights differences between three group of customer, namely baby boomers, generation X and generation Y in terms of perceived values that builds their trust in the context of MB applications use.
Consumer initial trust toward internet-only banks in France
Authors: Kaabachi Souheila , Ben Mrad Selima , Petrescu Maria 
Published: July 2017

Purpose
The purpose of this paper is to investigate internet-only banks’ (IOBs) adoption by French consumers and attempt to understand the factors that influence consumers’ initial trust in this type of service.

Design/methodology/approach
A non-probability convenience sample of potential IOBs adopters from France was used to test a structural equation model that analyzed the antecedents of initial trust and usage intentions of IOBs.

Findings
The study shows that trust is a major influencer in IOBs’ adoption in France. It has also been found that consumer familiarity with internet banking, high perceived structural assurance, perceived website quality, bank reputation and relative advantage are critical factors influencing IOBs’ initial trust formation.

Research limitations/implications
This study shows the applicability of the initial trust-building model in the context of IOBs and underlines the importance of factors such as familiarity, reputation and perceived quality in the context of online banking services in France.

Practical implications
This paper provides e-banking companies with the most important factors that contribute to build the initial trust of customers. E-banks need to focus on making themselves known and promoting their brand more effectively through advertising and advocacy.

Originality/value
This study contributes significantly to the marketing research related to consumer trust and brand reputation, as well as to the electronic banking literature. The results show the importance of initial trust in the context of services and the main factors that influence it, including a key branding variable such as reputation. The paper also focuses on the IOBs’ adoption in France, a market understudied compared to the USA, and seeks to understand the mechanisms associated with the initial formation of French consumers’ trust toward it.
Profit or utility maximizing? Strategy, tactics and the Municipal Tramways of York, c. 1918-1935
Authors: Tennent Kevin D. 
Published: July 2017

Purpose
This paper aims to contest Mees’ (2010) theory that publicly owned public transport operators normatively target their resources to maximize service rather than profit. Mees argues that neoliberal governments in the Anglosphere were mistaken to privatize their undertakings, yet it is shown that the British ethos of municipal trading meant that municipalities always saw public transport as more of a business than a service.

Design/methodology/approach
The author uses an archival microstudy of the municipal tramway undertaking of the English city of York, using municipal archives triangulated with local and industry media sources.

Findings
The paper proposes the refination of the Mees spectrum of public transport from public to private (2010, pp. 73-75) to note that public undertakings can be operated within a profit-maximizing framework.

Originality/value
This paper provides a rare historical explication of an individual municipal trading enterprise and tramway system placed in its economic context together with its wider theoretical implications.
The direct and interactive effects of job insecurity and job embeddedness on unethical pro-organizational behavior
Authors: Ghosh Sumit Kumar 
Published: July 2017

PurposeThe purpose of this paper is to empirically examine both the direct effects and the interactive effects of job insecurity and job embeddedness on unethical pro-organizational behavior.Design/methodology/approachData were collected, using established scales, from employees of different Indian organizations. In all, 346 responses were collected. The data were analyzed using a stepwise multiple regression technique.FindingsThe results of the analysis reveal that both job insecurity and job embeddedness are positively linked to unethical pro-organizational behavior. Further, the relationship between job insecurity and unethical pro-organizational behavior is moderated by job embeddedness.Research limitations/implicationsThe study’s results indicate that managers should be aware that employees who run the risk of losing their jobs might be inclined to perform pro-organizational behavior that could be unethical. Intrinsically, such acts could be detrimental to the organization’s long-term health and therefore managers should be vigilant and timely in discouraging this behavior.Originality/valueUnethical pro-organizational behavior as a means used by employees to combat job insecurity has not previously been addressed by researchers. Thus, this study contributes to the literature through its empirical examination of the role of job insecurity and job embeddedness as factors influencing unethical pro-organizational behavior.
Understanding citizenship behavior of academics in American- vs Continental European-modeled universities in Turkey
Authors: Inelmen Kivanc , Selekler-Goksen Nisan , Yildirim-Öktem Özlem 
Published: July 2017

PurposeThe purpose of this paper is to understand the impact of university tradition, justice perceptions and quality of leader-member exchange (LMX) on the faculty members’ tendency to engage in organizational citizenship behavior (OCB) from the perspective of social exchange theory (SET). Attention is drawn to the need to contextualize the established relationships between OCB and its antecedents, as direction and strength of relationships may vary in different contexts.Design/methodology/approachThe study uses a sequential mixed method design comprising a survey of 203 faculty members, and 15 semi-structured interviews both undertaken in several universities in Turkey. Hierarchical regression and discriminant analyses were used for the quantitative phase, followed by the qualitative phase that includes compiled quotes and content analysis.FindingsAnalyses provide strong support for the impacts of university tradition and LMX on OCB. The compiled quotes largely support the quantitative findings. Additionally, content analysis reveals sources and consequences of injustice and mechanisms to cope with it among academics.Practical implicationsThe findings have implications for university administrators who are looking for ways to increase OCB and enhance justice perception. LMX emerges as a significant factor in encouraging OCB regardless of university tradition. In order to enhance justice perceptions, Continental European-modeled universities should allocate workload and resources in a fair manner, while American-modeled universities should apply procedures consistently across people and time.Originality/valueThe inclusion of university tradition as an independent variable is a contribution as it contextualizes the relationship between OCB and its antecedents, verifying SET for both contexts. Using a mixed method design, the study provides an enriched understanding of OCB.