bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Midazolam-Ketamine Anesthesia on the Haematological and Biochemical Parameters Using Haloperidol or Chlordiazepoxide Premedication in Adult Male Bonnet Macaques (Macaca radiata)
Authors: Sannappa Naik Kamalesh Kumar Kuskur , Chandy George , Sooryadas Surendran , Dinesh Parathazhathayil , Dominic John Martin Kurishinkal , Meleppatt Deepa Padinhare , Babu Binoy 
Published: September 2024

Introduction: It is important to capture wild animals with minimal stress to reduce morbidity and mortality. Oral premeditates have the potential to reduce stress during handling and ease the subsequent administration of anesthetic drugs. This study was conducted to evaluate the hematological and serum biochemical changes associated with anesthesia in male Bonnet Macaques using haloperidol or chlordiazepoxide premedication.
Materials and methods: Twelve adult male Bonnet Macaques aged around 4 to 6 years were randomly allotted to two groups of six each. The duration of the study was five hours. Animals of Group I were administered chlordiazepoxide (10 mg/kg body weight) orally and animals of Group II were administered haloperidol (1 mg/kg body weight) orally four hours before anesthetizing with the intramuscular injection of midazolam (0.1 mg/kg) and ketamine (10 mg/kg). Hematological parameters such as hemoglobin concentration, erythrocyte, total leucocyte count, the volume of packed red cells, granulocyte, monocyte, and lymphocyte count were evaluated. Biochemical parameters such as creatine kinase, aspartate aminotransferase, alanine aminotransferase, cortisol, glucose, calcium, sodium, and potassium were evaluated from the venous blood sample collected at 0th minute and 30th minute after induction of anesthesia.
Results: The results of the current study indicate that in hematological parameters, the volume of packed cells was significantly different at 0th and 30th minute in both groups. The total leucocyte count was significantly different at 0th and 30th minute in Group I and Group Ⅱ, and the monocyte count was significantly different at 0th and 30th minute in Group I. For biochemical parameters, a significant difference was observed in creatine kinase in group II at 0th and 30th minute and cortisol at time 0th between Group I and Group II.
Conclusion: These results highlight the impact of anesthesia protocols on stress responses in Bonnet Macaques. Haloperidol premedication was linked to a greater increase in cortisol and creatine kinase, indicating higher stress and muscle damage compared to chlordiazepoxide.
Penerapan Model Problem Based Learning untuk Meningkatkan Kemampuan Berpikir Logis Matematis Siswa SMP Negeri 6 Malang
Authors: Hermansyah Tutus Sri , Zukhrufurrohmah Zukhrufurrohmah , Masfufah Titik 
Published: September 2024

Penelitian tindakan kelas ini bertujuan untuk meningkatkan kemampuan berpikir logis matematis siswa melalui penerapan model pembelajaran Problem Based Learning (PBL). Penelitian ini menggunakan pendekatan kuantitatif dan kualitatif, melibatkan 30 siswa kelas XI di SMP Negeri 6 Malang, dan dilaksanakan dalam dua siklus pembelajaran pada bulan Juli 2024. Setiap siklus terdiri dari empat tahapan utama: perencanaan, pelaksanaan, observasi, dan refleksi. Instrumen yang digunakan dalam penelitian ini meliputi rencana pembelajaran dengan model PBL, Lembar Kerja Peserta Didik (LKPD), soal tes tertulis, dan lembar observasi. Hasil penelitian menunjukkan peningkatan yang signifikan baik dalam keterlaksanaan pembelajaran PBL maupun kemampuan berpikir logis matematis siswa. Pada siklus 1, keterlaksanaan pembelajaran mencapai dan meningkat menjadi pada siklus 2. Kemampuan berpikir logis matematis siswa juga meningkat dari pada siklus 1 menjadi pada siklus 2. Peningkatan ini menunjukkan bahwa penerapan model PBL efektif dalam meningkatkan kemampuan berpikir logis matematis siswa.
Cuidados paliativos pediátricos según el modelo de Marjory Gordon: Revisión Sistemática
Authors: Vilca Ruiz Joselyn Mayerli , Fernández Nieto Miriam Ivonne 
Published: September 2024

Introducción: Los cuidados paliativos pediátricos tienen como objetivo principal mejorar la calidad de vida del niño y su familia, aliviando el sufrimiento físico, emocional, social y espiritual asociado con la enfermedad grave. El personal de enfermería para poder brindar una atención adecuada tiene que realizar una valoración de primera línea que sea adecuada y esta es la que nos postula la teorizante Marjory Gordon que nos ofrece valorar con los once Patrones funcionales. Objetivo: Hacer un análisis de los estudios realizados sobre los cuidados paliativos pediátricos según el modelo de Marjory Gordon. Metodología: Es una investigación de tipo cualitativa, retrospectiva, mediante una revisión sistemática utilizando la técnica documental para recolección de información en las diferentes bases de datos científicas como, Google Académico, Pub Med, Scielo y Dialnet, además se utilizó los operadores booleanos como son “AND” “OR” y “NOT”, y para la obtención de información se utilizó declaración PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Resultados: Se localizaron 103 artículos los cuales se fue descartando por su similitud y nos quedamos con 54 documentos, de los cuales 5 cumplieron los criterios de inclusión que fueron artículos en inglés y español, publicados desde 2020 al 2024, los estudios mencionaron que los patrones funcionales se utilizan para los cuidados en la práctica clínica. Conclusión: Estudios mostraron que las teorías de enfermería en la práctica paliativa destacan la Teoría del cuidado humanizado de Jean Watson el cual permite realizar intervenciones que se ajustan a las necesidades del paciente pediátrico y familia.
Curso de historia y filosofía de la biología 2023-3
Authors: Michán Layla 
Published: September 2024

En el 2023 me toca junto con la historiadora de la botánica Graciela Zamudio impartir el curso de historia y filosofía de la biología (https://sites.google.com/bioinformacion.org/lab/cursos/fhb) de manera intensiva durante tres semanas en modalidad presencial.
Seminarios y clubs de lectura
Authors: Michán Layla 
Published: September 2024

<b>
Seminarios
</b>
Seminario Rafael Martín del Campo: https://www.facebook.com/seminariozooloogia/?locale=es_LA
<b>
Clubs le lectura
</b>
Leer en grupo, discutir ideas, compartir impresiones y diseccionar el contenido de un texto es una excelente manera de hacer lectura grupal, aprender y escuchar otras interpretaciones.
BIOdatos: las definiciones de dato(s) en biociencias
Authors: Michán Layla 
Published: September 2024

Tener definiciones claras, precisas y compartidas es una condición indispensable para construir conocimiento, el concepto de dato ha tenido una historia interesante y se han generado gran cantidad de definiciones. Se considera que los buenos datos biológicos para que sean útiles deben cumplir con laos principios FAIR.
Rekontruksi Gending Lelambatan Klasik Gilak Embat dan Tabuh Pisan pada Sekaa Gong Desa Kwanji Sempidi
Authors: Mariyana I Nyoman , Putra I Made Dwi Andika , Bawa Putu Tiodore Adi 
Published: September 2024

Di Desa Kwanji Sempidi, terdapat salah satu Gong Kebyar yang konon adalah Gong Kebyar pertama yang ada di Kelurahan Sempidi. Sekaa Gong Desa Kwanji, memiliki beberapa jenis tabuh lelambatan klasik yang menjadi ciri khas dari Gong Desa Kwanji seperti : Gilak Embat, Tabuh Pisan Kwanji, Tabuh Telu (Tabuh Telu Dang, Tabuh Telu Dung, Bebonangan) Tabuh Pat (Gagak, Semarandana, Lodra, Subandar, Saga Manis), Tabuh Lima, Tabuh Nem (Galang Kangin, Tangis), Tabuh Kutus, (Lasem Kwanji, Pelayon). Tabuh-tabuh lelambatan tersebut sangat menarik dan mempunyai perbedaan dari jenis-jenis atau gaya penyajian gending lelambatan klasik pagongan pada umumnya. Akibat usia pemain yang semakin menua bahkan beberapa pemain (penglingsir) yang meninggal, ada beberapa jenis gending asli Gong Kwanji yang perlu “diselamatkan” dengan merekontruksinya kembali bersama regenerasi pemainnya yakni gending Gilak Embat dan Tabuh Pisan. Melalui metode wawancara dan demontrasi gending-gending ini dapat direkontruksi kembali dan dimainkan oleh generasi penerusnya dengan tetap mempertahankan gaya permainan dan pola-pola pukulan kekendangan, yang menjadi ciri khas dari Gong Kwanji. Proses rekontruksi ini melibatkan penglingsir Gong Kwanji dan Bendasa Adat Kwanji sebagai pengayom Gong Desa Kwanji.
Senmedeltida textskatt i uppländska kyrkor
Authors: Sandquist Öberg Christina 
Published: September 2024

(Late Medieval Text Treasure in the Churches of Uppland. All Preserved Scrolls with Comments and Analyses.) This is the main publication of the research project Late Medieval Text Treasure in the Churches of Uppland, devoted to the works of artists who, like Albertus Pictor during the Late Middle Ages, with pictures and words decorated the churches of Uppland, a politically and ecclesiastically central region at that time. In their work, these artists brought vibrant life to scenes from the Old and New Testament, from the typological compendium Biblia pauperum, and from various legends and tales.
In this volume the preserved scrolls that often accompany the pictures, are for the first time critically edited, translated and commented upon in their entirety. In a comprehensive introduction, the main results of the analysis, concerning the scrolls and some unique motifs, are summarized. An index of the scrolls further facilitates the use of the work.
INTENSIFIKASI LAHAN PEKARANGAN MENJADI HERBAL SMART GARDEN DI KELURAHAN KALISEGORO GUNUNGPATI SEMARANG
Authors: Suwarni Sri , Christina Odilia Dea , Sitepu Harum , Trimonica Tessa 
Published: September 2024

Intensifikasi lahan di kelurahan dan pekarangan warga menjadi Solusi untuk lahan pekarangan yang tidak digunakan menjadi bermanfaat dan menambahkan nilai keuntungan yaitu memudahkan kebutuhan obat penyakit ringan di masyarakat . Lahan Pekarangan di Kelurahan Kalisegoro Gunungpati Semarang diberdayakan menjadi Herbal Smart Garden oleh tim urban farming, remaja dan lansi dimulai dengan penyuluhan macam-macam tanaman berkhasiat obat hingga cara pengolahan urban farming tanaman herbal yang dibibitkan dengan menggunakan media polybag dilatihkan cara pengolahan tanah serta penanamanya akan menjadi berguna untuk msyarakat, dan informasi tentang khasiat dan pemgolahan menjadi obat dengan smart dapat menggunakan sistem informasi ataupun e-katalog tanaman obat yang ditanam di herbal garden tersebut. Tanah yang kosong termanfaatkan menjadi lahan sumber tanaman obat yang dapat digunakan untuk kepentingan penyakit ringan dan imunitas tubuh Masyarakat itu sendiri.
Kegiatan Mahasiswa KKN di Desa Bipak Kali dalam Membangun Generasi Cerdas Melalui Literasi Membaca dengan Inisiatif Bersama Karang Taruna Kecamatan Gunung Bintang Awai Kabupaten Barito Selatan
Authors: Elisa Saputri  , Yamowa’A Bate’E  , Lexi Elang Taruna R. Aden  , Jhonatan Jhonatan  , Sonar Womswor  , Sela M  , Andreas Vicky Anugrahno Pansla  , Lola Saputri  , Aning Kristiani  , Yuni Esa Gresella  , Yusnani Yusnani  , Mitae Mitae  , Kristina Kristina  , Runia Mustika  , Tira Watie  , Sri Anjini  , Handriani JH  
Published: September 2024

This research aims to improve reading literacy among children in Bipak Kali Village through collaboration between KKN students and Karang Taruna. This program focuses on increasing reading interest, reading ability, and access to literacy resources. A mixed-method approach was used in this study, which involved surveys, interviews, participatory observations, and group discussions. The work program carried out includes literacy socialization, the formation of study groups, and other supporting activities. The evaluation was carried out to measure the effectiveness and impact of the program. The results of the study showed a significant increase in reading interest, reading ability, and access to literacy resources among children in Bipak Kali Village. Community participation has also increased, and the program has received support from various parties, including the Youth Organization, the village government, and community leaders. Program evaluations identify several challenges and provide recommendations for the development of more effective and sustainable literacy programs.
Ethics of Using Social Media for Learning: Encouraging Appreciation and Responsibility
Authors: Erwin Erwin , Dakhalan Andi Muhammad 
Published: September 2024

In today’s era that is all about technology, social media is an important need for many people. Social media is now inherent in social circles, especially the current millennial generation. Almost all teenagers, adults and even children have social media. It is not uncommon for us to always be connected to the outside world through social media. The use of the internet through social media has presented a web forum that can form an online community. The purpose of the study is to find out the learning attitudes that can encourage students to use social media in learning in high school, as well as have a potential impact in encouraged, respectful and responsible attitudes in the use of social media as learning. The research uses a quantitative method that can be used to determine the results of research on student learning activities. The data was obtained from documents in the form of books and journals related to the theme, finally this research focused on encouraging students to social media as a form of attitude and responsibility in the world of Education. The results of these observations explain the ethics of using social media for learning in encouraging students to act respectfully and responsibly which can play an important role in encouraging the use of social media for students to be more concerned about their responsibilities. In this use, it is inseparable from an ability and a deficiency in the attitude of students if applied in learning, therefore educators and parents are very influential. The conclusion obtained from the study is that in encouraging the ethics of using social media today, social media has shown great hope in encouraging education. In this observation, the use of social media can be used as an attitude of respect and responsibility. With the use of social media, you can form good ethics to encourage mutual respect.
ANÁLISE DE ATIVIDADES PARA O ENSINO DE ESTATÍSTICA: UM OLHAR PARA O LIVRO DIDÁTICO
Authors: Rosendo Adriana , Barbosa Geovane , Silva Santos Sidney 
Published: September 2024

Esse artigo tem por finalidade realizar a análise de atividades em um Livro Didático buscando como tema a Compreensão da Linguagem Tabular e Gráfica, relacionadas ao ensino de estatística no 6º ano do ensino fundamental. Buscamos investigar se as atividades propostas no livro didático levam em consideração os níveis de compreensão da linguagem tabular e gráfica defendidos por Wainer (1995) e Curcio (1989). Possui abordagem qualitativa de tipologia documental. Os resultados indicam que a primeira atividade analisada promove entendimento na leitura tabular apenas no nível elementar. No que se refere à segunda atividade de leitura gráfica identificamos entendimento em um nível, com relação aos demais, não foi possível afirmar na atividade uma proposta em que o estudante fizesse inferências e previsões de um determinado resultado ou acontecimento em função da sua experiência e de seus conhecimentos prévios, não houve também, uma reflexão crítica sobre as atividades que estão sendo desenvolvidas.
Vertical Farming: A Promising Solution to Urban Agriculture
Authors: Buragohain Ruprekha , Hazarika Bikash , Deka Bhabesh , Devi S. Helena , Bathari Manha 
Published: September 2024

Urban agriculture refers to the agricultural activities such as plant production for home consumption and income generation in the urban areas especially cities. The concept of urban agriculture has been popularizing but in today’s century it is also facing certain problems such as limited land resources, population increase etc. Vertical farming is a type of urban agriculture, through which we could seek solutions to the problems that urban agriculture has been facing in the recent times. Vertical farming refers to the growing of crops in vertically stacked structures especially under controlled environmental conditions and using a suitable growing medium to increase the crop production per square metre by utilizing the vertical space for cultivation [1]. A wide range of crops can be cultivated in vertical farming with the use of techniques such as hydroponics, aeroponics, aquaponics, artificial lighting, inside the controlled environment of a greenhouse. Vertical farming is needed to provide solution to the problems of urban agriculture in terms of providing food security to the growing population, efficient land utilization, water conservation, increased crop production etc. However, vertical farming has certain disadvantages as well such as high initial investment cost, high energy cost and high maintenance cost. Therefore, further research and development strategies are necessary to overcome such disadvantages for increasing its effectiveness to meet the food demands of the growing population as well as the future generation in a sustainable manner.
Silica‐Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica
Authors: Clarke Aimee K. , James Michael J. , O'Brien Peter , Taylor Richard J. K. , Unsworth William P. 
Published: October 2016

AbstractSilica‐supported AgNO3 (AgNO3–SiO2) catalyzes the dearomatizing spirocyclization of alkyne‐tethered aromatics far more effectively than the analogous unsupported reagent; in many cases, reactions which fail using unsupported AgNO3 proceed effectively with AgNO3–SiO2. Mechanistic studies indicate that this is a consequence of silver nanoparticle formation on the silica surface combined with a synergistic effect caused by the silica support itself. The remarkable ease with which the reagent can be prepared and used is likely to be of much synthetic importance, in particular, by making nanoparticle catalysis more accessible to non‐specialists.
Polymer–Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
Authors: Kaczmarek James C. , Patel Asha K. , Kauffman Kevin J. , Fenton Owen S. , Webber Matthew J. , Heartlein Michael W. , DeRosa Frank , Anderson Daniel G. 
Published: October 2016

AbstractTherapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(β‐amino esters) (PBAEs) and nucleic acids have previously demonstrated potential utility for local delivery applications. To expand this potential utility to include systemic delivery of mRNA, hybrid polymer–lipid nanoformulations for systemic delivery to the lungs were developed. Through coformulation of PBAEs with lipid–polyethylene glycol (PEG), mRNA formulations were developed with increased serum stability and increased in vitro potency. The formulations were capable of functional delivery of mRNA to the lungs after intravenous administration in mice. To our knowledge, this is the first report of the systemic administration of mRNA for delivery to the lungs using degradable polymer–lipid nanoparticles.
Toehold‐Mediated Displacement of an Adenosine‐Binding Aptamer from a DNA Duplex by its Ligand
Authors: Monserud Jon H. , Macri Katherine M. , Schwartz Daniel K. 
Published: October 2016

AbstractDNA is increasingly used to engineer dynamic nanoscale circuits, structures, and motors, many of which rely on DNA strand‐displacement reactions. The use of functional DNA sequences (e.g., aptamers, which bind to a wide range of ligands) in these reactions would potentially confer responsiveness on such devices, and integrate DNA computation with highly varied molecular stimuli. By using high‐throughput single‐molecule FRET methods, we compared the kinetics of a putative aptamer–ligand and aptamer–complement strand‐displacement reaction. We found that the ligands actively disrupted the DNA duplex in the presence of a DNA toehold in a similar manner to complementary DNA, with kinetic details specific to the aptamer structure, thus suggesting that the DNA strand‐displacement concept can be extended to functional DNA–ligand systems.
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench‐Stable Organozinc Reagents
Authors: Greshock Thomas J. , Moore Keith P. , McClain Ray T. , Bellomo Ana , Chung Cheol K. , Dreher Spencer D. , Kutchukian Peter S. , Peng Zhengwei , Davies Ian W. , Vachal Petr , Ellwart Mario , Manolikakes Sophia M. , Knochel Paul , Nantermet Philippe G. 
Published: October 2016

AbstractThe reactivity of a representative set of 17 organozinc pivalates with 18 polyfunctional druglike electrophiles (informers) in Negishi cross‐coupling reactions was evaluated by high‐throughput experimentation protocols. The high‐fidelity scaleup of successful reactions in parallel enabled the isolation of sufficient material for biological testing, thus demonstrating the high value of these new solid zinc reagents in a drug‐discovery setting and potentially for many other applications in chemistry. Principal component analysis (PCA) clearly defined the independent roles of the zincates and the informers toward druggable‐space coverage.
Highly Luminescent Cesium Lead Halide Perovskite Nanocrystals with Tunable Composition and Thickness by Ultrasonication
Authors: Tong Yu , Bladt Eva , Aygüler Meltem F. , Manzi Aurora , Milowska Karolina Z. , Hintermayr Verena A. , Docampo Pablo , Bals Sara , Urban Alexander S. , Polavarapu Lakshminarayana , Feldmann Jochen 
Published: October 2016

AbstractWe describe the simple, scalable, single‐step, and polar‐solvent‐free synthesis of high‐quality colloidal CsPbX3 (X=Cl, Br, and I) perovskite nanocrystals (NCs) with tunable halide ion composition and thickness by direct ultrasonication of the corresponding precursor solutions in the presence of organic capping molecules. High angle annular dark field scanning transmission electron microscopy (HAADF‐STEM) revealed the cubic crystal structure and surface termination of the NCs with atomic resolution. The NCs exhibit high photoluminescence quantum yields, narrow emission line widths, and considerable air stability. Furthermore, we investigated the quantum size effects in CsPbBr3 and CsPbI3 nanoplatelets by tuning their thickness down to only three to six monolayers. The high quality of the prepared NCs (CsPbBr3) was confirmed by amplified spontaneous emission with low thresholds. The versatility of this synthesis approach was demonstrated by synthesizing different perovskite NCs.
Direct Mannich‐Type Reactions Promoted by Frustrated Lewis Acid/Brønsted Base Catalysts
Authors: Chan Jessica Z. , Yao Wenzhi , Hastings Brian T. , Lok Charles K. , Wasa Masayuki 
Published: October 2016

AbstractDirect Mannich‐type reactions that afford both α‐ and β‐amino esters by the reaction of a broad range of carbonyl compounds and aldimines are disclosed. The transformation is promoted by a sterically frustrated Lewis acid/Brønsted base pair, which is proposed to operate cooperatively: Within the catalyst complex, an enolate is generated that then reacts with a hydrogen‐bond‐activated imine. Noncovalent interactions between reactants and the catalyst provide selectivity and new opportunities for future catalyst design.