bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice
Authors: Yang Chun , Fujita Yuko , Ren Qian , Ma Min , Dong Chao , Hashimoto Kenji 
Published: April 2017

AbstractAccumulating evidence suggests that abnormalities in the composition of the gut microbiota may play a role in the pathogenesis of depression. Although approximately 30% mice are resilient to chronic social defeat stress (CSDS), the role of gut microbiota in this stress resilience is unknown. In this study, male C57BL/6 mice were exposed to a different CD1 aggressor mouse for 10 min on 10 consecutive days. A social interaction test was applied to distinguish between resilient and susceptible mice. Using 16S rRNA analysis, we examined the composition of gut microbiota in feces from control, resilient, and susceptible mice. The marked appearance of Bifidobacterium was detected in the resilient mice, whereas in the control and susceptible mice, Bifidobacterium were below the detection limit. Oral intake of Bifidobacterium significantly increased the number of resilient mice after CSDS compared with vehicle-treated mice. These findings suggest that Bifidobacterium may confer resilience to CSDS. Therefore, supplementation of Bifidobacterium may prevent the onset of depression from stress in humans. In addition, supplementation of Bifidobacterium may prevent or minimize relapse from remission induced by inflammation and/or stress in depressed patients.
Improving “color rendering” of LED lighting for the growth of lettuce
Authors: Han Tao , Vaganov Vitaliy , Cao Shixiu , Li Qiang , Ling Lili , Cheng Xiaoyao , Peng Lingling , Zhang Congzhi , Yakovlev Alexey N. , Zhong Yang , Tu Mingjing 
Published: April 2017

AbstractLight plays a vital role on the growth and development of plant. On the base of white light with high color rendering to the benefit of human survival and life, we proposed to improve “color rendering” of LED lighting for accelerating the growth of lettuce. Seven spectral LED lights were adopted to irradiate the lettuces under 150 μmol·m−2·s−1 for a 16 hd−1 photoperiod. The leaf area and number profiles, plant biomass, and photosynthetic rate under the as-prepared LED light treatments were investigated. We let the absorption spectrum of fresh leaf be the emission spectrum of ideal light and then evaluate the “color rendering” of as-prepared LED lights by the Pearson product-moment correlation coefficient and CIE chromaticity coordinates. Under the irradiation of red-yellow-blue light with high correlation coefficient of 0.587, the dry weights and leaf growth rate are 2–3 times as high as the sharp red-blue light. The optimized LED light for lettuce growth can be presumed to be limited to the angle (about 75°) between the vectors passed through the ideal light in the CIE chromaticity coordinates. These findings open up a new idea to assess and find the optimized LED light for plant growth.
Tips and Tricks to Improve Clinical and Aesthetic Outcomes in Latissimus Dorsi Flap Breast Reconstruction
Authors: Laporta Rosaria , Sorotos Michail , Longo Benedetto , Santanelli di Pompeo Fabio 
Published: April 2017

Background The aim of this study is to present technical strategies to decrease donor-site complications, to optimize breast shaping, and to achieve symmetry in one-stage procedure in latissimus dorsi (LD) flap reconstruction.
Methods Between 2004 and 2014, a retrospective review was performed on LD flap reconstructions. Demographics, reconstructive details, clinical and aesthetic outcomes were collected and analyzed. Patients were divided in historical control group (HCG) and new strategy group (NSG). In HCG, a horizontal/oblique LD skin paddle (SP) was drawn; only LD muscle was harvested for the implant pocket; and a contralateral symmetrization was planned without any algorithm. In NSG, a transverse LD-SP was centered on the middle to lower bra strap area; a double-layer muscle coverage was used to create the implant pocket; and a planning algorithm was developed to achieve symmetry.
Results A total of 418 breast reconstructions were performed on 296 patients. The two groups were homogeneous regarding demographics, mastectomy weight, and implant volume (p > 0.05). No differences were observed in the incidence of a contralateral surgery, mean hospitalization time, and mastectomy skin flap and nipple–areola complex complications (p > 0.05), while surgical revision of the balancing procedure was more common in HCG than NSG (p = 0.001). Overall, donor-site morbidities occurred in 50 cases including 3 (1%) seroma in NSG and 17 (14.1%) in HCG, and 8 (2.7%) wound dehiscence in NSG and 18 (14.5%) in HCG (p = 0.001). Mean number of take backs to the operating room for secondary procedure was statistically significant between the groups in favor of NSG (p = 0.001).
Conclusion Careful preoperative planning and adoption of appropriate reconstructive strategies can improve clinical and aesthetic outcomes in LD flap breast reconstruction at long-term follow-up.
Level of Evidence This is a level III, therapeutic study.
The Effects of Yoga in Patients Suffering from Subjective Tinnitus
Authors: Köksoy Sümbüle , Eti Can , Karataş Meltem , Vayisoglu Yusuf 
Published: April 2017

Introduction Tinnitus is a perception of sound in the absence of an external source and it is a distressing issue. Yoga is a system of mind-body practices with the goal of uniting the body, mind and soul. It has been shown to reduce anxiety and stress, as well as improving the quality of life.
Objective The aim of this study is to investigate the effects of yoga in patients suffering from chronic subjective tinnitus.
Methods Twelve subjects previously diagnosed with chronic subjective tinnitus were selected for the study. The patients were asked to attend to yoga classes once a week and to practice yoga at home using a worksheet for 3 months. Each yoga class consisted of body exercises (asana), breathing (pranayama) and meditation (shavasana and yoga nidra). Tinnitus scores before and after the yoga classes were compared using the Wilcoxon test.
Results Among the 12 patients, there were 4 men and 8 women and their mean age was 52.5 years. The median duration of tinnitus among the group was 5.4 years. There were statistically significant differences in the stress (p = 0.01), handicap (p = 0.004) and severity (p = 0.007) questionnaires scores.
Conclusion This study indicated that yoga practices may reduce life stress and symptoms of subjective tinnitus.
Ultrasonographic Evaluation of Uterine Involution in the Early Puerperium
Authors: Kristoschek Juliana Hocevar , Silva Fernanda Campos da , Vellarde Guillermo Coca , Moreira de Sá Renato Augusto 
Published: April 2017

Purpose Our aim was to describe the changes observed by ultrasonography in uterine dimensions during the early puerperium among women who experienced an uncomplicated puerperium. Additionally, the influence of parity, mode of delivery, breastfeeding and birth weight on uterine involution was evaluated.
Methods Ninety-one patients underwent an ultrasound examination on days 1 (D1), 2 (D2) and 7 (D7) of the postpartum period. The longitudinal, anteroposterior and transverse uterine diameters were measured, and the uterine volume was calculated by the formula: longitudinal diameter (LD) X anteroposterior diameter (APD) X transverse diameter (TD) X 0.45. The thickness and length of the uterine cavity were also measured.
Results The uterine volume and the LD, APD and TD decreased by 44.8%, 20.9%, 11.8% and 20.0% respectively. The uterine cavity thickness was reduced by 23%, and the length of the cavity was reduced by 27.2% on D7. Uterine involution was correlated inversely with parity when the day of the postpartum period was not taken into account (p = 0.01). However, when the uterine involution was correlated to parity separately, with D1, D2 or D3, no correlations were found. A significant difference occurred at D2, when it was found that the uterus had a smaller volume following cesarean section compared with vaginal delivery (p = 0.04). The high birth weight and breastfeeding were significantly related to uterine involution (p ≤ 0.01 and p = 0.04).
Conclusion The sonographic evaluation of the uterus in the early puerperium should consider birth weight, breastfeeding and parity, as well as the delivery route on D2, to identify abnormalities related to uterine involution.
„StigMa“ – Evaluation eines psychologischen Therapieprogramms zu Stigma-Management
Authors: Schenner Manuela , Kohlbauer Daniela , Meise Ullrich , Haller Christina , Pixner-Huber Martina , Stürz Kristina , Günther Verena 
Published: April 2017

Zusammenfassung
Ziel der Studie Evaluation des Therapieprogramms „StigMa“ zum Umgang mit internalisiertem Stigma für psychisch Kranke.
Methode 26 tagesklinische PatientInnen absolvierten das Programm „StigMa“, 20 Personen dienten als Kontrollgruppe. Prä-post-Messungen erfolgten mittels der Internalized Stigma of Mental Illness-Skala (ISMI) 1.
Ergebnisse Trotz sehr guter Bewertungen des Programms durch die Therapiegruppe, ließen sich keine signifikanten Interaktionseffekte nachweisen.
Schlussfolgerungen Unter Berücksichtigung inhaltlicher und methodischer Optimierung soll StigMa erneut evaluiert werden.
„Dass ich das ändern muss, damit ich nicht irgendwann kollabiere …“
Authors: Zimber Andreas , Hentrich Stephan , Meyer-Lindenberg Andreas 
Published: April 2017

Zusammenfassung
Ziel Identifizierung von Risiko- und Schutzfaktoren, die für die Entstehung psychischer Beeinträchtigungen von Führungskräften bedeutsam sind.
Methodik 15 Interviews mit psychisch belasteten Führungskräften wurden leitfadenorientiert durchgeführt und inhaltsanalytisch ausgewertet.
Ergebnisse Alle Probanden berichteten Beeinträchtigungen ihres psychischen Wohlbefindens. Deren Verlauf war mit der Risikowahrnehmung, der erlebten Handlungskontrolle, dem Gesundheits- und Erholungsverhalten der Führungskräfte und der Gesundheitskultur im Unternehmen assoziiert.
Schlussfolgerung Führungskräfte und Unternehmen sind stärker für die psychischen Risiken von Führungstätigkeiten zu sensibilisieren.
Erkennungsgüte dreier deutschsprachiger Screeninginstrumente für Depression bei hospitalisierten Patienten mit koronarer Herzerkrankung
Authors: Tschorn Mira , Rieckmann Nina , Arolt Volker , Beer Katja , Haverkamp Wilhelm , Martus Peter , Waltenberger Johannes , Müller-Nordhorn Jacqueline , Ströhle Andreas 
Published: April 2017

Zusammenfassung
Ziel Vergleich der Erkennungsgüte von drei Depressions-Screeninginstrumenten bei Patienten mit koronarer Herzerkrankung (KHK).
Methodik 1019 KHK-Patienten erhielten den Patient Health Questionnaire (PHQ-9 und PHQ-2) und die Hospital Anxiety and Depression Scale (HADS-D) sowie ein klinisches Interview (Composite International Diagnostic Interview) als Referenzstandard.
Ergebnisse Bezüglich der Erkennungsgüte waren PHQ-9 und HADS-D dem PHQ-2 überlegen. Optimale Cut-off-Werte waren 7 (PHQ-9 und HADS-D) und 2 (PHQ-2).
Schlussfolgerung PHQ-9 und HADS-D haben eine vergleichbare Diskriminationsfähigkeit für depressive Störungen bei KHK-Patienten.
Zusammenhänge des Stationsklimas mit objektiven Rahmenbedingungen psychiatrischer Stationen
Authors: Schalast Norbert , Sieß Julia 
Published: April 2017

Zusammenfassung
Ziel der Studie Prüfung der Zusammenhänge zwischen Rahmenbedingungen, klinischer Aufgabenstellung und dem Stationsklima in der allgemeinen (AP) und der forensischen Psychiatrie (FP).
Methode Einschätzung des Stationsklimas auf 104 Stationen (47 AP, 57 FP) mit dem kurzen Stationsklimabogen EssenCES, Erfassung von Stationsbedingungen und problematischen Vorkommnissen.
Ergebnisse Objektive Merkmale des Settings und Aspekte des Stationsklimas sind deutlich assoziiert.
Schlussfolgerungen Viele, aber nicht alle naheliegenden Annahmen über die Bedeutung objektiver Rahmenbedingungen werden bestätigt.
International multicenter comparative trial of endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for the treatment of malignant gastric outlet obstruction
Authors: Khashab Mouen , Bukhari Majidah , Baron Todd , Nieto Jose , El Zein Mohamad , Chen Yen-I , Chavez Yamile , Ngamruengphong Saowanee , Alawad Ahmad , Kumbhari Vivek , Itoi Takao 
Published: April 2017

Abstract
Background and study aims EUS-guided gastroenterostomy (EUS-GE) is a novel procedure that potentially offers long-lasting luminal patency without the risk of tumor ingrowth/overgrowth. This study compared the clinical success, technical success, adverse events (AEs), length of hospital stay (LOHS) and symptom recurrence in EUS-GE versus SGJ.
Methods This was a multicenter international retrospective comparative study of EUS-GE and SGJ in patients with malignant gastric outlet obstruction (GOO) who underwent either EUS-GE or SGJ. EUS-GE was performed using lumen apposing metal stents.
Results A total of 93 patients with malignant GOO treated with either EUS-GE (n = 30) or SGJ (n = 63) were identified. Peritoneal carcinomatosis was present in 13 (43 %) patients in the EUS-GE group and 7 (11 %) patients in the SGJ group (P < 0.001). Although the technical success rate was significantly higher in the SGJ group as compared to the EUS-GE group (100 % vs. 87 %, P = 0.009), the clinical success rate was not different (90 % vs. 87 %, P = 0.18, OR 0.8, 95 %CI 0.44 – 7.07). The rate of AEs was lower in the EUS-GE group, but the difference was not statistically significant (16 % vs 25 %, P = 0.3). The mean LOHS was similar in the EUS-GE group compared to SGJ (P = 0.35). The rate of recurrent GOO was not different between the two groups (3 % vs. 14 %, P = 0.08). Similarly, the mean time to reintervention was similar (88 days vs. 121 days, P = 0.83).
Conclusions EUS-GE is associated with equivalent efficacy and safety as compared to surgical GJ. This is the first comparative trial between both techniques and suggests EUS-GE as a non-inferior but less invasive alter to surgery.
Utilization trends in inpatient endoscopic retrograde cholangiopancreatography (ERCP): A cross-sectional US experience
Authors: Ahmed Moiz , Kanotra Ritesh , Savani Ghanshyambhai , Kotadiya Fenilkumar , Patel Nileshkumar , Tareen Sarah , Fasullo Matthew , Kesavan Mayurathan , Kahn Ahsan , Nalluri Nikhil , Khan Hafiz , Pau Dhaval , Abergel Jeffrey , Deeb Liliane , Andrawes Sherif , Das Ananya 
Published: April 2017

Abstract
Study aims The goal of our study was to determine the current trends for inpatient utilization for endoscopic retrograde cholangiopancreatography (ERCP) and its economic impact in the United States between 2002 and 2013.
Patients and methods A Nationwide Inpatient Sample from 2002 through 2013 was examined. We identified ERCPs using International Classification of Diseases (ICD-9) codes; Procedure codes 51.10, 51.11, 52.13, 51.14, 51.15, 52.14 and 52.92 for diagnostic and 51.84, 51.86, 52.97 were studied. Rate of inpatient ERCP was calculated. The trends for therapeutic ERCPs were compared to the diagnostic ones. We analyzed patient and hospital characteristics, length of hospital stay, and cost of care after adjusting for weighted samples. We used the Cochran-Armitage test for categorical variables and linear regression for continuous variables.
Results A total of 411,409 ERCPs were performed from 2002 to 2013. The mean age was 59 ± 19 years; 61 % were female and 57 % were white. The total numbers of ERCPS increased by 12 % from 2002 to 2011, which was followed by a 10 % decrease in the number of ERCPs between 2011 and 2013.There was a significant increase in therapeutic ERCPs by 37 %, and a decrease in diagnostic ERCPs by 57 % from 2002 to 2013. Mean length of stay was 7 days (SE = 0.01) and the mean cost of hospitalization was $20,022 (SE = 41).
Conclusions Our large cross-sectional study shows a significant shift in ERCPs towards therapeutic indications and a decline in its conventional diagnostic utility. Overall there has been a reduction in inpatient ERCPs.
Clinical usefulness of magnifying endoscopy for non-ampullary duodenal tumors
Authors: Mizumoto Takeshi , Sanomura Yoji , Tanaka Shinji , Kuroki Kazutoshi , Kurihara Mio , Yoshifuku Yoshikazu , Oka Shiro , Arihiro Koji , Shimamoto Fumio , Chayama Kazuaki 
Published: April 2017

Abstract
Study aims This study aimed to investigate the clinical usefulness of magnifying endoscopy (ME) for non-ampullary duodenal tumors.
Patients and methods We enrolled 103 consecutive patients with non-ampullary duodenal tumors that were observed by ME with narrow-band imaging (ME-NBI) and had pit pattern analysis before endoscopic resection at Hiroshima University Hospital before December 2014. ME-NBI images were classified as Type B or Type C according to the Hiroshima classification, and pit patterns were classified as regular or irregular. We studied the clinicopathological features and diagnoses with ME-NBI and pit pattern analyses according to the Vienna classification (category 3: 73 patients; category 4: 30 patients).
Results Category 4 lesions were significantly larger than category 3 lesions. According to ME-NBI images, category 4 Type C lesions (83 %) were significantly more common than category 4 Type B lesions (17 %). According to pit pattern analyses, category 4 irregular lesions 4 (77 %) were significantly more common than category 4 regular lesions (23 %). The accuracies of using Type C ME-NBI images and irregular pit patterns to diagnose category 4 lesions were 87 % and 84 %, the sensitivities were 83 % and 77 %, and the specificities were 89 % and 88 %, respectively. There was no significant difference between ME-NBI and pit pattern analyses for diagnosing the histologic grade of non-ampullary duodenal tumors.
Conclusion Our study showed that ME-NBI and pit pattern analysis had equivalent abilities to determine the histologic grade of non-ampullary duodenal tumors. ME-NBI may be more useful because it is a simple, less time-consuming procedure.
Influence of Light, Temperature, and Macronutrients on Growth and Scopolamine Biosynthesis in Duboisia species
Authors: Ullrich Sophie , Rothauer Andreas , Hagels Hansjörg , Kayser Oliver 
Published: April 2017

AbstractScopolamine is used in the pharmaceutical industry as a precursor in the organic synthesis of different classes of important active substances and is extracted in large scale from field grown Duboisia plants. Previous research revealed that plant growth as well as production of scopolamine and its derivatives varies strongly depending on abiotic factors. However, only a small amount of systematic research has been done on the influence of environmental conditions on scopolamine and biomass production, so far. In order to extend knowledge in this field, plants of three different genotypes (wild type Duboisia myoporoides and hybrids of D. myoporoides and Duboisia leichhardtii) were grown in climate chambers under controlled conditions in order to systematically analyse the influence of temperature (20, 24, 28 °C), light (50–300 µmol/m2 × s, 12, 18, 24 h per day) and macronutrients (nitrogen, calcium, potassium) on growth and scopolamine biosynthesis. The data indicate that light intensity and daily exposure to light have a major impact on scopolamine production and plant development, whereas temperature only shows a minor influence. Nitrogen (N) positively affects biomass production with increasing levels up to 4 mM, but is negatively correlated with scopolamine content. Calcium (Ca) shows a negative influence on scopolamine biosynthesis at increased levels above 1 mM as well. Potassium (K) neither affects biomass nor scopolamine production within the tested concentration range (0.05–4 mM). All in all, it can be concluded that light intensity and nitrogen supply are especially important regulating variables that can be applied in a targeted manner for influencing scopolamine and biomass production.
ROLE of inter-related population-level host traits in determining pathogen richness and zoonotic risk
Authors: Lucas Tim C.D. , Wilkinson-Herbots Hilde M. , Jones Kate E. 
Published: April 2017

AbstractZoonotic diseases are an increasingly important source of human infectious diseases, and host pathogen richness of reservoir host species is a critical driver of spill-over risk. Population-level traits of hosts such as population size, host density and geographic range size have all been shown to be important determinants of host pathogen richness. However, empirically identifying the independent influences of these traits has proven difficult as many of these traits directly depend on each other. Here we develop a mechanistic, metapopulation, susceptible-infected-recovered model to identify the independent influences of these population-level traits on the ability of a newly evolved pathogen to invade and persist in host populations in the presence of an endemic pathogen. We use bats as a case study as they are highly social and an important source of zoonotic disease. We show that larger populations and group sizes had a greater influence on the chances of pathogen invasion and persistence than increased host density or the number of groups. As anthropogenic change affects these traits to different extents, this increased understanding of how traits independently determine pathogen richness will aid in predicting future zoonotic spill-over risk.
Performance measurement system innovations in hospitals as translation processes
Authors: Leotta Antonio , Ruggeri Daniela 
Published: April 2017

Purpose
The purpose of this paper is to highlight how the variety of the actors involved in a performance measurement system (PMS) innovation are spread out in time and space. Healthcare contests are examined, where such an innovation is influenced by present and past systems and practices (spread out in time), and by managerial and health-professional actors (spread out in space).

Design/methodology/approach
Drawing on Callon’s actor network theory, the authors describe PMS innovations as processes of translation, and distinguish between incremental and radical innovations. The theoretical arguments are used to explain the evidence drawn from a longitudinal case study carried out in an Italian public teaching hospital, referring to the period from 1998 up to 2003.

Findings
The conceptual framework shows how the translation moments lead to a recognition of the different actants involved in a PMS innovation, how their interests are interrelated and mobilized. Moreover, it shows how the interaction among the actants involved in the process is related to the type of PMS innovation, i.e. radical vs incremental. The case evidence offers detailed insights into the phenomenon, testing the explanatory power of the framework, and highlights how the failure of one of the translation moments can compromise the success of a PMS innovation.

Originality/value
This study differs from the extant accounting literature on PMS innovations as it highlights how the introduction of a new PMS can be affected by some elements of the previous systems “package,” which are relevant for the mobilization of the actants through the new project.