bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Butane Hash Oil (Marijuana Wax)–Induced Psychosis
Authors: Keller Corey J. , Chen Evan C. , Brodsky Kimberly , Yoon Jong H. 
Published: January 2016

Background: Marijuana is one of the most widely used controlled substances in the United States. Despite extensive research on smoked marijuana, little is known regarding the potential psychotropic effects of marijuana “wax,” a high-potency form of marijuana that is gaining in popularity. Case: The authors present a case of “Mr. B,” a 34-year-old veteran who presented with profound psychosis in the setting of recent initiation of heavy, daily marijuana wax use. He exhibited incoherent speech and odd behaviors and appeared to be in a dream-like state with perseverating thoughts about his combat experience. His condition persisted despite treatment with risperidone 4 mg twice a day (BID), but improved dramatically on day 8 of hospitalization with the return of baseline mental function. Following discharge, Mr. B discontinued all marijuana use and did not exhibit the return of any psychotic symptoms. Discussion: This study highlights the need for future research regarding the potential medical and psychiatric effects of new, high-potency forms of marijuana. Could cannabis have a dose-dependent impact on psychosis? What other potential psychiatric effects could emerge heretofore unseen in lower potency formulations? Given the recent legalization of marijuana, these questions merit timely exploration.
Relapse Prevention Medications in Community Treatment for Young Adults with Opioid Addiction
Authors: Vo Hoa T. , Robbins Erika , Westwood Meghan , Lezama Debra , Fishman Marc 
Published: January 2016

Background: Despite the well-known effectiveness and widespread use of relapse prevention medications such as extended release naltrexone (XR-NTX) and buprenorphine for opioid addiction in adults, less is known about their use in younger populations. Methods: This was a naturalistic study using retrospective chart review of N = 56 serial admissions into a specialty community treatment program that featured the use of relapse prevention medications for young adults (19–26 years old) with opioid use disorders. Treatment outcomes over 24 weeks included retention and weekly opioid-negative urine tests. Results: Patients were of mean age 23.1, 70% male, 86% Caucasian, 82% with history of injection heroin use, and treated with either buprenorphine (77%) or XR-NTX (23%). The mean number of XR-NTX doses received was 4.1. Retention was approximately 65% at 12 weeks and 40% at 24 weeks, and rates of opioid-negative urine were 50% at 12 weeks and 39% at 24 weeks, with missing samples imputed as positive. There were no statistically significant differences in retention ( t = 1.87, P = .06) or in rates of weekly opioid-negative urine tests ( t = 1.96, P = .06) between medication groups, over the course of 24 weeks. The XR-NTX group had higher rates of weekly negative urine drug tests for other nonopioid substances ( t = 2.83, P < .05) compared with the buprenorphine group. Males were retained in treatment longer and had higher rates of opioid-negative weeks compared with females. Conclusions: These results suggest that relapse prevention medications including both buprenorphine and XR-NTX can be effectively incorporated into standard community treatment for opioid addiction in young adults with good results. Specialty programming focused on opioid addiction in young adults may provide a promising model for further treatment development.
Structural characterization of sulfated arabinans extracted fromCladophora glomerataKützing and their macrophage activation
Authors: Surayot Utoomporn , Hun Lee Ju , Kanongnuch Chartchai , Peerapornpisal Yuwadee , Park WooJung , You SangGuan 
Published: January 2016

AbstractWater-soluble sulfated heteropolysaccharides were extracted from Cladophora glomerata Kützing and fractionated by ion-exchange chromatography, which yielded two subfractions, F1 and F2. The crude and fractionated polysaccharides (F1 and F2) mostly consisted of carbohydrates (62.8–74.5%) with various amounts of proteins (9.00–17.3%) and sulfates (16.5–23.5%), including different levels of arabinose (41.7–54.4%), galactose (13.5–39.0%), glucose (0.80–10.6%), xylose (6.84–13.4%), and rhamnose (0.20–2.83%). Based on the size exclusion chromatography (SEC) profiles, the crude and fractions mainly contained one peak with shoulders having molecular weight (Mw) ranges of 358–1,501 × 103. The F1 fraction stimulated RAW264.7 cells to produce considerable amounts of nitric oxide and cytokines compared to the crude and F2 fraction. The backbone of the most potent immunostimulating fraction (F1) was α-(1→4)-L-arabinopyranoside with galactose and xylose residues as branches at O-2 position, and sulfates mainly at O-2 position as well.
Blood Pressure Mobile Monitoring for Pregnant Woman Based Android System
Authors: Supriyanti Retno , Erfayanto Uji , Ramadani Yogi , Murdyantoro Eko , Widodo Haris B. 
Published: January 2016

Abstract
Currently, at least 18,000 women die every year in Indonesia due to pregnancy or childbirth. It means that every half hour a woman dies due to pregnancy or childbirth. As a result, every year 36,000 children became orphans. The high maternal mortality rate was put Indonesia on top in ASEAN. The main causes of maternal mortality are high-risk pregnancy. Mothers who have diseases like high blood pressure, pre-eclampsia, diabetes, hyperthyroidism, and already over 40 years old and infectious diseases such as rubella, hepatitis and HIV can be factors that lead to high-risk pregnancy. This paper will discuss the development of a blood pressure monitoring device that is suitable for pregnant women. It is based on convenience for pregnant women to get the equipment that is flexible with her presence. Results indicate that the equipment is in use daily support for pregnant women therefore, one of the causes of maternal mortality can be detected earlier.
Fungi: A Very Short Introduction
Authors: Money Nicholas P. 
Published: January 2016

Abstract
The diversity of the mycological world is far greater than most people imagine. Tens of thousands of fungal species have been described and many more are known only from the abundance of their genes in soil and water. Fungi are hugely important as agents of wood decay in forests, and, as parasites, they have caused the deaths of millions of people by ravaging crops and reshaping natural ecosystems. Fungi perform essential functions in ecosystems, and are important to both agriculture and biotechnology. Fungi: A Very Short Introduction highlights the variety and extraordinary natures of fungi, revealing the remarkable facts of fungal biology and the global significance of these enchanting organisms.
Changes in composition, ecology and structure of high-mountain vegetation: a re-visitation study over 42 years
Authors: Evangelista Alberto , Frate Ludovico , Carranza Maria Laura , Attorre Fabio , Pelino Giovanni , Stanisci Angela 
Published: January 2016

Abstract
High-mountain ecosystems are increasingly threatened by climate change, causing biodiversity loss, habitat degradation and landscape modifications. However, very few detailed studies have focussed on plant biodiversity in the high mountains of the Mediterranean. In this study, we investigated the long-term changes that have occurred in the composition, structure and ecology of high-mountain vegetation in the central Apennines (Majella) over the last 42 years. We performed a re-visitation study, using historical and newly collected vegetation data to explore which ecological and structural features have been the most successful in coping with climatic changes. Vegetation changes were analysed by comparing geo-referenced phytosociological relevés collected in high-mountain habitats (dolines, gentle slopes and ridges) on the Majella massif in 1972 and in 2014. Composition analysis was performed by detrended correspondence analysis, followed by an analysis of similarities for statistical significance assessment and by similarity percentage procedure (SIMPER) for identifying which species indicate temporal changes. Changes in ecological and structural indicators were analysed by a permutational multivariate analysis of variance, followed by a post hoc comparison. Over the last 42 years, clear floristic changes and significant ecological and structural variations occurred. We observed a significant increase in the thermophilic and mesonitrophilic plant species and an increment in the frequencies of hemicryptophytes. This re-visitation study in the Apennines agrees with observations in other alpine ecosystems, providing new insights for a better understanding of the effects of global change on Mediterranean high-mountain biodiversity. The observed changes in floristic composition, the thermophilization process and the shift towards a more nutrient-demanding vegetation are likely attributable to the combined effect of higher temperatures and the increase in soil nutrients triggered by global change. The re-visitation approach adopted herein represents a powerful tool for studying climate-related changes in sensitive high-mountain habitats.
The binary fraction and mass segregation in Alpha Persei open cluster
Authors: Sheikhi Najmeh , Hasheminia Maryam , Khalaj Pouria , Haghi Hosein , Zonoozi Akram Hasani , Baumgardt Holger 
Published: January 2016

Abstract
We have obtained membership probabilities of stars within a field of ${\sim }3\deg$ from the centre of the open cluster Alpha Persei using proper motions and photometry from the PPMXL and Wide-field Infrared Survey Explorer catalogues. We have identified 810 possible stellar members of Alpha Persei. We derived the global and radial present-day mass function (MF) of the cluster and found that they are well matched by two-stage power-law relations with different slopes at different radii. The global MF of Alpha Persei shows a turnover at m = 0.62 M⊙ with low- and high-mass slopes of αlow = 0.50 ± 0.09 (0.1 &lt; m/ M⊙ &lt; 0.62) and αhigh = 2.32 ± 0.14 (0.62 ≤ m/ M⊙ &lt; 4.68), respectively. The high-mass slope of the cluster increases from 2.01 inside 1$_{.}^{\circ}$10 to 2.63 outside 2$_{.}^{\circ}$2, whereas the mean stellar mass decreases from 0.95 to 0.57 M⊙ in the same regions, signifying clear evidence of mass segregation in the cluster. From an examination of the high-quality colour–magnitude data of the cluster and performing a series of Monte Carlo simulations, we obtained a binary fraction of fbin = 34 ± 12 per cent for stars with 0.70 &lt; m/ M⊙ &lt; 4.68. This is significantly larger than the observed binary fraction, indicating that this open cluster contains a large population of unresolved binaries. Finally, we corrected the MF slopes for the effect of unresolved binaries and found low- and high-mass slopes of αlow = 0.89 ± 0.11 and αhigh = 2.37 ± 0.09 and a total cluster mass of 352 M⊙ for Alpha Persei.
X-ray flares in GRBs: general considerations and photospheric origin
Authors: Beniamini Paz , Kumar Pawan 
Published: January 2016

Abstract
Observations of X-ray flares from Gamma Ray Bursts imply strong constraints on possible physical models. We provide a general discussion of these. In particular, we show that in order to account for the relatively flat and weak optical flux during the X-ray flares, the size of the emitting region should be ≲3 × 1014cm. The bolometric luminosity of flares also strongly constrain the energy budget, and are inconsistent with late time activity of a central engine powered by the spin-down of a magnetar. We provide a simple toy model according to which flares are produced by an outflow of modest Lorentz factor (a few tens instead of hundreds) that is launched more or less simultaneously with the highly relativistic jet which produced the prompt gamma-ray emission. The ‘slower moving outflow produces the flare as it reaches its photosphere. If the X-ray flare jets are structured, the existence of such a component may naturally resolve the observational challenges imposed by flares, outlined in this work.
Creating a Cadre of Fellowship-Trained Medical Educators: A Qualitative Study of Faculty Development Program Leaders’ Perspectives and Advice
Authors: Coates Wendy C. , Runde Daniel P. , Yarris Lalena M. , Rougas Steven , Guth Todd A. , Santen Sally A. , Miller Jessica , Jordan Jaime 
Published: January 2016

Purpose
Well-trained educators fill essential roles across the medical education continuum. Some medical schools offer programs for existing faculty to enhance teaching and scholarship. No standard postgraduate training model exists for residency graduates to attain competency as faculty members before their first academic appointment. The objective of this study is to inform the development of postgraduate medical education fellowships by exploring perceptions of educational leaders who direct well-established faculty development programs.

Method
The authors undertook a qualitative study, using purposeful sampling to recruit participants and a constant comparative approach to identify themes. They conducted semistructured telephone interviews with directors of faculty development fellowships using an interpretivist/constructivist paradigm (November 2013). Questions addressed curricular and fiscal structure, perceived benefits and challenges, and advice for starting a postgraduate fellowship.

Results
Directors reported institutional and participant benefits, notably the creation of a community of educators and pool of potential leaders. Curricular offerings focused on learning theory, teaching, assessment, leadership, and scholarship. Funding and protected time were challenges. Advice for new program directors included evaluating best practices, defining locally relevant goals; garnering sufficient, stable financial support; and rallying leaders’ endorsement.

Conclusions
Medical education fellowships cultivate leaders and communities of trained educators but require participants to balance faculty responsibilities with professional development. Advice of current directors can inform the development of postgraduate programs modeled after accredited clinical specialty fellowships. Programs with the support of strategic partners, financial stability, and well-defined goals may allow new faculty to begin their careers with existing competency in medical education skills.
Reducing Implicit Gender Leadership Bias in Academic Medicine With an Educational Intervention
Authors: Girod Sabine , Fassiotto Magali , Grewal Daisy , Ku Manwai Candy , Sriram Natarajan , Nosek Brian A. , Valantine Hannah 
Published: January 2016

Purpose
One challenge academic health centers face is to advance female faculty to leadership positions and retain them there in numbers equal to men, especially given the equal representation of women and men among graduates of medicine and biological sciences over the last 10 years. The purpose of this study is to investigate the explicit and implicit biases favoring men as leaders, among both men and women faculty, and to assess whether these attitudes change following an educational intervention.

Method
The authors used a standardized, 20-minute educational intervention to educate faculty about implicit biases and strategies for overcoming them. Next, they assessed the effect of this intervention. From March 2012 through April 2013, 281 faculty members participated in the intervention across 13 of 18 clinical departments.

Results
The study assessed faculty members’ perceptions of bias as well as their explicit and implicit attitudes toward gender and leadership. Results indicated that the intervention significantly changed all faculty members’ perceptions of bias (P < .05 across all eight measures). Although, as expected, explicit biases did not change following the intervention, the intervention did have a small but significant positive effect on the implicit biases surrounding women and leadership of all participants regardless of age or gender (P = .008).

Conclusions
These results suggest that providing education on bias and strategies for reducing it can serve as an important step toward reducing gender bias in academic medicine and, ultimately, promoting institutional change, specifically the promoting of women to higher ranks.
Expression of segment polarity genes in brachiopods supports a non-segmental ancestral role ofengrailedfor bilaterians
Authors: Vellutini Bruno C. , Hejnol Andreas 
Published: January 2016

AbstractThe diverse and complex developmental mechanisms of segmentation have been more thoroughly studied in arthropods, vertebrates and annelids—distantly related animals considered to be segmented. Far less is known about the role of “segmentation genes” in organisms that lack a segmented body. Here we investigate the expression of the arthropod segment polarity genesengrailed,wnt1andhedgehogin the development of brachiopods—marine invertebrates without a subdivided trunk but closely related to the segmented annelids. We found that a stripe ofengrailedexpression demarcates the ectodermal boundary that delimits the anterior region ofTerebratalia transversaandNovocrania anomalaembryos. InT. transversa, thisengraileddomain is abutted by a stripe ofwnt1expression in a pattern similar to the parasegment boundaries of insects—except for the expression ofhedgehog, which is restricted to endodermal tissues of the brachiopod embryos. We found thatpax6andpax2/5/8, putative regulators ofengrailed, also demarcate the anterior boundary in the two species, indicating these genes might be involved in the anterior patterning of brachiopod larvae. In a comparative phylogenetic context, these findings suggest that bilaterians might share an ancestral, non-segmental domain ofengrailedexpression during early embryogenesis.
The Northern Arizona SNP Pipeline (NASP): accurate, flexible, and rapid identification of SNPs in WGS datasets
Authors: Sahl Jason W. , Lemmer Darrin , Travis Jason , Schupp James M. , Gillece John D. , Aziz Maliha , Driebe Elizabeth M. , Drees Kevin , Hicks Nathan , Williamson Charles H.D. , Hepp Crystal , Smith David , Roe Chandler , Engelthaler David M. , Wagner David M. , Keim Paul 
Published: January 2016

AbstractWhole genome sequencing (WGS) of bacteria is becoming standard practice in many laboratories. Applications for WGS analysis include phylogeography and molecular epidemiology, using single nucleotide polymorphisms (SNPs) as the unit of evolution. The Northern Arizona SNP Pipeline (NASP) was developed as a reproducible pipeline that scales well with the large amount of WGS data typically used in comparative genomics applications. In this study, we demonstrate how NASP compares to other tools in the analysis of two real bacterial genomics datasets and one simulated dataset. Our results demonstrate that NASP produces comparable, and often better, results to other pipelines, but is much more flexible in terms of data input types, job management systems, diversity of supported tools, and output formats. We also demonstrate differences in results based on the choice of the reference genome and choice of inferring phylogenies from concatenated SNPs or alignments including monomorphic positions. NASP represents a source-available, version-controlled, unit-tested method and can be obtained from tgennorth.github.io/NASP.
Folding PDZ2 domain using the Molecular Transfer Model
Authors: Liu Zhenxing , Reddy Govardhan , Thirumalai D. 
Published: January 2016

AbstractA major challenge in molecular simulations is to describe denaturant-dependent folding of proteins order to make direct comparisons within vitroexperiments. We use the molecular transfer model (MTM), which is currently the only method that accomplishes this goal albeit phenomenologically, to quantitatively describe urea-dependent folding of PDZ domain, which plays a significant role in molecular recognition and signaling. Experiments show that urea-dependent unfolding rates of the PDZ2 domain exhibit a downward curvature at high urea concentrations ([C]s), which has been interpreted by invoking the presence of a sparsely populated high energy intermediate. Simulations using the MTM and a coarse-grained Self-Organized Polymer (SOP) representation of PDZ2 are used to show that the intermediate (IEQ), which has some native-like character, is present in equilibrium both in the presence and absence of urea. The free energy profiles as a function of the structural overlap order parameter show that there are two barriers separating the folded and unfolded states. Structures of the transition state ensembles, (TSE1 separating the unfolded andIEQandTSE2 separatingIEQand the native state), determined using thePfoldmethod, show thatTSE1 is greatly expanded whileTSE2 is compact and native-like. Folding trajectories reveal that PDZ2 folds by parallel routes. In one pathway folding occurs exclusively throughI1, which resemblesIEQ. In a fraction of trajectories, constituting the second pathway, folding occurs through a combination ofI1and a kinetic intermediate. We establish that the radius of gyration () of the unfolded state is more compact (by ∼ 9%) under native conditions. Theory and simulations show that the decrease inoccurs on the time scale on the order of utmost ~ 20μβ.The modest decrease inand the rapid collapse suggest that high spatial and temporal resolution, currently beyond the scope of most small angle X-ray scattering experiments, are needed to detect compaction in finite-sized proteins. The present work further establishes that MTM is efficacious in producing nearly quantitative predictions for folding of proteins under conditions used to carry out experiments.
HASE: Framework for efficient high-dimensional association analyses
Authors: Roshchupkin G.V. , Adams H.H.H. , Vernooij M.W. , Hofman A. , Van Duijn C.M. , Ikram M.A. , Niessen W.J. 
Published: January 2016

ABSTRACTLarge-scale data collection and processing have facilitated scientific discoveries in fields such as genomics and imaging, but cross-investigations between multiple big datasets remain impractical. Computational requirements of high-dimensional association studies are often too demanding for individual sites. Additionally, the sheer size of intermediate results is unfit for collaborative settings where summary statistics are exchanged for meta-analyses. Here we introduce the HASE framework to perform high-dimensional association studies with dramatic reduction in both computational burden and storage requirements of intermediate results. We implemented a novel meta-analytical method that yields identical power as pooled analyses without the need of sharing individual participant data. The efficiency of the framework is illustrated by associating 9 million genetic variants with 1.5 million brain imaging voxels in three cohorts (total N=4,034) followed by meta-analysis, on a standard computational infrastructure. These experiments indicate that HASE facilitates high-dimensional association studies enabling large multicenter association studies for future discoveries.