bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel approach for the treatment of diabetic foot ulcers using a multimodal wound matrix: a clinical study
Authors: Simman Richard , Bakewell Suzanne J , Bell Desmond , Shuman Susan , Cheney Mary 
Published: September 2024

Objective: Innovation in wound healing, particularly regarding diabetic foot ulcers (DFUs), is needed to reverse the number of diabetes-related amputations. This study evaluated a novel approach and performance of a multimodal wound matrix in converting stalled DFUs into a healing trajectory. Method: Patients with either type 1 or 2 diabetes and with foot ulcers (Wagner grade 1 and 2), were screened to determine eligibility for treatment. Ulcers improving >30% in area during a two-week screening phase were not eligible for the study treatment phase. The study was an open-label trial conducted in three phases: screening, treatment and healing confirmation. Patients enrolled in the study received a treatment protocol that included application of a wound matrix to the ulcer and offloading. Results: A total of 19 patients (15 males, four females) with a median age of 60 years, and a median ulcer duration of 36 weeks took part in the study. Patients showed an average four-week percentage area reduction (PAR) of 62%, a 12-week PAR of 94%, and a 12-week healing rate of 57% (8/14). Conclusion: Results of this study support the viability and potential of a novel approach to treating DFUs that includes use of a multimodal wound matrix.
Biological status of blue swimming crab population (Portunus pelagicus) in Estuarine Water at Langsa City
Authors: Sari Nurdian Novita , Febri Suri Purnama , Putriningtias Andika , Haser Teuku Fadlon , Rusydi Rachmawati , Hanisah Hanisah , Nazlia Suraiya , Aprita Ika Rezvani 
Published: September 2024

Many factors encourage the exploitation of the blue swimming crab in the estuarine water of Langsa City. Therefore, maintaining crab populations in nature through fishing regulation becomes an important effort. Evaluation of the biological aspects of the blue swimming crab population the estuarine waters of Langsa City has the main role in the arrangement of regulation. This study aimed to determine the biology of the blue swimming crab population in the estuarine waters of Langsa City. This research was carried out in August 2022 in the estuarine waters of Langsa City. The method used was the survey method. The crab samples were taken randomly from the crab fishermen as much as 10% of the catch. Sampling once a week at 2 different location points for 1 month. The results showed that the relationship between carapace width and weight of male and female blue swimming crabs (Portunus pelagicus) had a negative allometric growth pattern because of the value of b 3, namely 1.22 and 1.21. The sex ratio of blue swimming crabs was not 1:1 or unbalanced. Gonadal maturity of male crabs was highest in level I, meanwhile the female could achieve the gonadal maturity in level V. During the research, the water quality of estuarine waters was in optimum condition.Keywords:Blue swimming crabBiological aspectEstuarinePopulation
Analysis of abundance and ditribution of parrotfish (Leptoscarus vaigiensis) in seagrass ecosystems in Muris Besar Village, Demta District, Jayapura Regency, Papua
Authors: Runtuboi Dirk Y. P. , Kalor John Dominggus , Paiki Kalvin , Jaban Robert D , Indrayani Ervina , Mantayborbir Vyona , Izaac Fransina A 
Published: September 2024

Parrotfish is the species Leptoscarus vaigiensis. Leptoscarus vaigiensis is a species of fish found in Muris Besar Village's waters, and it lives in seagrass meadow areas. This study aims to find parrot fish species abundance and distribution (Leptoscarus vaigiensis) in seagrass environments. Benefits from this research are anticipated to include supporting data and information, particularly for the fisheries industry in this water area, and significant information for preserving seagrass ecosystems as a specialized habitat for parrotfish (Leptoscarus vaigiensis). The Water Visual Census (UVC) is used to assess parrot habitat in the waterways. Direct observation at the research site is used to learn about and gather data about the object under study. Counting stationary points, transects, timed swimming at stationary sites, divers remaining in one location and surveying a specified radius for a certain amount of time are the major categories into which UVC methods fall. The research locations are Waipa Beach, Ugape Cape, Augara Beach, Muris Besar Village, Demta District, Jayapura Regency, Papua. The highest abundance value is at station 1, with an abundance value of 1,300 ind/m², while the lowest is at station 2, with an abundance value of 700 ind/m². Leptoscarus vaigiensis has a species distribution with a morality index value between 0.33 and 0.50. The distribution of parrotfish (Leptoscarus vaigiensis) in seagrass ecosystems is categorized as comparable according to the criteria for distribution patterns.Keywords:DistributionParrotfishMuris Besar VillagerAbundanceSeagrass beds
Single-microresonator-based dynamic photonic molecule switch
Authors: Tao Zihan , Shen Bitao , Li Wencan , Xing Luwen , Wang Haoyu , Wu Yichen , Tao Yuansheng , Zhou Yan , He Yandong , Peng Chao , Shu Haowen , Wang Xingjun 
Published: September 2024

We propose a dynamic on-chip photonic molecule switch in an ultra-compact multimode silicon microring, allowing for flexible either nonlinear control or loss reduction.
This strategy leads to a record low-loss transition (Qi ~ 10 million) under hundred-GHz FSR level.
Optically detected magnetic resonance with light-sheet microscopy
Authors: Wang Shuo , Ai Ming-Zhong , Fan Jing-Wei , Ye Jun-Chen , Lin Chao , Li Quan , Liu Ren-Bao 
Published: September 2024

To overcome the phototoxicity in diamond-based bio-sensing, we applied light sheet microscopy to optically detected magnetic resonance measurement. Three-dimensional imaging and nano-thermometry with sensitivity
~3 K/Hz are achieved.
Diagnosis of brucellosis: Combining tests to improve performance
Authors: Loubet Paul , Magnan Chloé , Salipante Florian , Pastre Théo , Keriel Anne , O’Callaghan David , Sotto Albert , Lavigne Jean-Philippe 
Published: September 2024

Introduction
Brucellosis, a zoonotic infectious disease caused by bacteria of the genus Brucella, remains a significant global health concern in many parts of the world. Traditional diagnostic methods, including serological tests, suffer from limitations, including low sensibility and high false-positive rates, emphasizing the need for improved diagnostic strategies. In this study, we aimed to optimize diagnostic accuracy by reevaluating serological tests and exploring novel diagnostic algorithms.

Methods
A retrospective observational study was conducted using sera collected between June 2012 and June 2023 at the French National Reference Center for Brucella. Various serological tests, including Rose Bengal plate test (RBT), standard agglutination test (SAT), Brucellacapt, and ELISA for IgM and IgG, were performed. Different diagnostic algorithms were evaluated, combining RBT with SAT, Brucellacapt, and ELISA to enhance the performance of diagnostic tests.

Results
Among 3587 sera analyzed, 148 were confirmed cases of human brucellosis. Individual serological tests exhibited good sensitivity and specificity but lacked diagnostic accuracy. However, combining RBT with SAT or Brucellacapt significantly improved diagnostic performance, with reduced false positives. The most promising results were observed when an algorithm was built combining RBT, Brucellacapt, and ELISA for IgM and IgG (a score value of 0.5 with 90.5% for sensitivity, 99.7% for specificity, 92.4% for PPV, and 99.6% for NPV).

Conclusions
Serological tests remain crucial for brucellosis diagnosis, but their limitations necessitate innovative diagnostic approaches. Combining multiple serological tests in diagnostic algorithms shows promise in improving diagnostic accuracy. Efforts to refine diagnostic, strengthen surveillance, and raise awareness are essential for effective brucellosis control, particularly in resource-limited settings.
Clinical characteristics of patients with different subtypes of gestational diabetes mellitus: research results
Authors: Volkova N. I. , Davidenko I. Y. , Degtiareva Y. S. , Sorokina Y. A. , Avrutskaya V. V. 
Published: September 2024

INTRODUCTION. Gestational diabetes mellitus (GDM) is one of the most common diseases during pregnancy. To date, there is evidence showing that not all pregnant women with GDM have the same risks of developing complications. Identification of patients at increased risk of complications may be necessary given the increasing prevalence of GDM. The need for a more detailed study of GDM subtypes to identify patients at high risk of complications formed the basis of the study.PURPOSE. Determination of anamnestic, phenotypic, and biochemical characteristics of GDM subtypes for the further development of diagnostic and treatment methods.MATERIALS AND METHODS. A single-center observational prospective study was carried out at the Department of Internal Medicine No. 3 of the Rostov State Medical University of the Ministry of Health of the Russian Federation in the period from April 2021 to August 2022. The study included 130 pregnant women. Participants underwent an oral glucose tolerance test with 75 g of glucose assessing fasting, 60- and 120-minutes venous plasma glucose and insulin levels, and fasting blood was drawn to determine levels of main lipid metabolism indicators, apolipoprotein A, and apolipoprotein B, adiponectin, leptin and omentin, glycated hemoglobin, C-reactive protein. All study participants underwent anamnesis and physical ­examination with assessment of body mass index (BMI), blood pressure, signs of acanthosis nigricans, and a questionnaire. When GDM was detected, the Matsuda index was calculated: >50th percentile in comparison with the values of pregnant women without carbohydrate metabolism disorders, the patient belonged to the group of GDM with β-cell dysfunction; <50th percentile - to the GDM group with predominant insulin resistance.RESULTS AND DISCUSSION. Women with GDM and insulin resistance were older, had a higher BMI before pregnancy, greater weight gain, and more often had signs of acanthosis nigricans compared to patients with GDM and β-cell dysfunction. Also, when comparing patients with different subtypes of GDM, numerous biochemical differences and lifestyle features were identified..CONCLUSION. We demonstrated pronounced anamnestic, phenotypic, and biochemical heterogeneity in patients with different subtypes of GDM, which may become the basis for the further development of verification of GDM subtypes.
Analysis of the effectiveness of outpatient treatment of patients with diabetic foot
Authors: Komelyagina E. Y. , Antsiferov M. B. 
Published: September 2024

BACKGROUND: Diabetic foot syndrome is a late complication of diabetes mellitus and the main reason for non-traumatic amputations of the lower extremities in diabetic patients. Currently, standards of medical care have been developed and implemented for the treatment and prevention of this complication. At the same time, there is a lack of publications on the effectiveness of specialized care, especially at the pre-hospital stage.AIM: To analyze the results of treatment of patients with diabetic foot on an outpatient basis in a specialized department and identify the factors affecting them.MATERIALS AND METHODS: Medical records of patients with diabetic foot ulcers receiving specialized outpatient treatment in the diabetic foot department were analyzed. All patients underwent an assessment of the peripheral sensitivity and blood flow of low extremities during the initial examination. Treatment was prescribed in accordance with the presence and severity of infection and ischemia of the affected limb. The number of amputations at different levels, the percentage of healed and unhealed wounds during the year were analyzed. Predictors of high amputations and non healing during the year were identified.RESULTS: Out of 503 patients with diabetic foot, neuropathic diabetic foot was diagnosed in 336 (67%) patients, neuro-ischemic in 167 (33%). Healing without amputations in the general cohort of patients was noted in 407 cases (81%). In 32 (7%) cases, amputations were required, of which: 23 (5%) within the foot, 3 above ankle (0.6%), 6 above knee (1.2%). Death occurred in 6 patients (1.2%), 2 of them after hip amputation. 61 patients (12%) continued to be treated at the end of the study. The predictors of high amputations in the general cohort of patients were age, impaired arterial blood flow in the arteries of the lower extremities, the depth of the Wagner ulcer and the level of glycated hemoglobin. Predictors of the non healing during the year were: the presence of impaired arterial blood flow and untimely treatment for specialized medical care.CONCLUSION: The data obtained demonstrated the high effectiveness of specialized care for patients with diabetic foot ulcers at the prehospital stage
Practical Applications of Russian DPP4 Inhibitor Gosogliptin in “Palitra” Large-Scale Observational Study
Authors: Shestakova M. V. , Biryukova E. V. 
Published: September 2024

BACKGROUND: To date, the results of Metformin, Gosogliptin and combination thereof have not been studied on a large patient population with type 2 diabetes mellitus (DM2), including comorbid patients, in real clinical settings in the Russian Federation.AIM: The aim is to evaluate the efficacy, safety, treatment adherence and satisfaction of patients with DM2 with the use of Metformin and Gosogliptin sugar-lowering drugs and combination thereof in routine clinical practice.MATERIALS AND METHODS: The nationwide PALITRA multicenter observational study was conducted among patients with DM2 who were prescribed therapy with Metformin or Gosogliptin or combination thereof in everyday clinical practice. Groups were formed according to the sugar-lowering drug administered; a total of 5741 patients aged 18 to 65 years with DM2 and a wide comorbidity profile participated. The observation period was 6 months. Body weight, body mass index (BMI), blood pressure (BP), glycated hemoglobin (HbA1c) level, glycemic parameters, and biochemical parameters (ALT, AST and plasma creatinine) were recorded initially and 3 and 6 months after the initiation of therapy with the study drugs. Adherence to therapy and patient and physician satisfaction with the treatment were assessed using Likert scale.RESULTS: HbA1c level decreased by 1.03% in the Metformin monotherapy group and by 0.95% in the Gosogliptin monotherapy and Metformin and Gosogliptin combination therapy groups by Week 24. By the end of the study, 49.6% of patients with DM2 reached the target HbA1c level (<7.0%). The proportion of patients with HbA1c level <7.0% was 61.0% in the Metformin group, 47.75% and 47.2% in the Gosogliptin and Metformin/Gosogliptin dual combination therapy groups, respectively. The incidence of hypoglycemic episodes was very low throughout the whole period of observation, during which body weight decreased slightly. High satisfaction of patients and physicians with DM2 treatment was shown. This was reflected by high Likert scale scores.CONCLUSION: It has been proved that Metformin, Gosogliptin and the combination of Metformin and Gosogliptin were highly effective and safe (low incidence of hypoglycemia and no effect on body weight), and patients and physicians had been satisfied with the sugar-lowering therapy in a sufficient number of Russian patients with DM2 and a wide comorbidity profile.
The Language Science Station at Planet Word: a language research and engagement laboratory at a language museum
Authors: Vaughn Charlotte , Mechtenberg Hannah , Contreras Jessica Orozco 
Published: September 2024

Abstract
The Language Science Station (LSS) is a research and engagement laboratory operating at the Planet Word museum in Washington, DC, representing a unique partnership between language researchers and a museum dedicated to language. The LSS invites Planet Word guests – ranging from local to international visitors – to participate in research studies and engage in educational activities with student language scientists from diverse academic backgrounds. In doing so, we broaden participation in the language sciences among both the researchers and the participant population. This paper outlines the goals, values, and structure of the LSS, highlighting our dual emphases on research and engagement. We focus on several aspects of the project. These include our novel multi-university researcher-museum partnership, the different considerations that we find are necessary for conducting research in a museum setting compared to the laboratory, and our training of researchers and student research assistants. The paper also provides reflections from students on their interactions with museum visitors. We share our experiences with the broader scholarly community in an effort to lower barriers for other behavioral scientists interested in combining research and engagement in public venues.
Genetics of female and male infertility
Authors: Friedrich Corinna , Tüttelmann Frank 
Published: September 2024

Abstract
Infertility is defined as the inability to conceive within one year of unprotected intercourse, and the causes are equally distributed between both sexes. Genetics play a crucial role in couple infertility and respective diagnostic testing should follow available guidelines. Appropriate tiered genetic analyses require comprehensive physical examination of both partners in an infertile couple. A wide range of chromosomal and monogenic variants can be the underlying genetic cause of infertility in both women and men. Accurate clinical phenotyping, together with identification of the genetic origin, helps to recommend the proper treatment and to counsel couples on the success rates and potential risks for offspring.
Asymptotic Properties of ReLU FFN Sieve Estimators
Authors: Fabozzi Frank J. , Fallahgoul Hasan , Franstianto Vincentius , Loeper Grégoire 
Published: September 2024

Abstract
Recently, machine learning algorithms have increasing become popular tools for economic and financial forecasting. While there are several machine learning algorithms for doing so, a powerful and efficient algorithm for forecasting purposes is the multi-layer, multi-node neural network with rectified linear unit (ReLU) activation function – deep neural network (DNN). Studies have demonstrated the empirical applications of DNN but have devoted less research to investigate its statistical properties which is mainly due to its severe nonlinearity and heavy parametrization. By borrowing tools from a non-parametric regression framework, sieve estimator, we first show that there exists such a sieve estimator for a DNN. We next establish three asymptotic properties of the ReLU network: consistency, sieve-based convergence rate, and asymptotic normality, and then validate our theoretical results using Monte Carlo analysis.
De facto-Kategorisierung und Ungleichheit bei der Kita-Platzvergabe in Deutschland: Der Rechtsanspruch auf Frühe Bildung und seine Realität
Authors: Bader Samuel , Scholz Antonia 
Published: September 2024

Zusammenfassung
Der Beitrag untersucht die Platzvergabe in Kindertageseinrichtungen. Trotz langjährigen Ausbaus und eines gesetzlichen Platzanspruchs zeigen sich in Deutschland Nutzungsunterschiede in Abhängigkeit von der sozialen Herkunft. Angesichts vielerorts fehlender Kita-Plätze wird das Aufnahme- zu einem Auswahlverfahren. Im deutschen Kita-Mehrebenensystem ergeben sich hierbei Spielräume auf Einrichtungsebene. Diskutiert wird, inwiefern es sich dabei um einen Prozess der Kategorisierung handelt, der zu ungleicher Teilhabe an Früher Bildung führen kann.
Wer an der Platzvergabe in deutschen Kitas beteiligt ist und welche Aufnahmekriterien Anwendung finden, wird mit den TALIS Starting Strong Daten quantitativ untersucht und international eingeordnet. Es zeigt sich, dass Einrichtungsleitungen eine zentrale Rolle spielen. Die Aufnahmekriterien erweisen sich häufig als ungleichheitsrelevant, teils offensichtlich, teils bedingt durch komplexere Zusammenhänge. Angesichts fortbestehender Platzknappheit gilt es diese kritisch zu diskutieren.
Effets de l’accès au financement sur la performance des PME féminines au Congo
Authors: Offele Okopoue Jacqueline , Bangagnan Yanga Elfy Déba 
Published: September 2024

Les problèmes liés à l’accès au crédit sont au cœur des débats dans le monde en général et en Afrique en particulier. Ainsi, cet article a pour objectif d’analyser les effets de l’accès au financement sur la performance des petites et moyennes entreprises (PME) féminines en République du Congo. Pour y parvenir, nous avons utilisé les données primaires de 11 105 entreprises, issues du Recensement des très petites, petites, moyennes entreprises et des artisans (RTPMEA) réalisé par l’Institut national de la statistique (INS, 2017) de la République du Congo en 2017. À cet effet, les estimations sont basées sur la méthode des doubles moindres carrés des variables instrumentales. Les résultats obtenus montrent que l’accès au financement est un facteur favorable pour la performance des entreprises féminines au Congo et donne lieu à des recommandations de politique économique d’inclusion, de formation et d’incitation.
The PornLoS Treatment Program: Study protocol of a new psychotherapeutic approach for treating pornography use disorder
Authors: Stark Rudolf , Markert Charlotte , Golder Sarah , Psarros Rhea , Discher Julian P. , Khatib Said , Metzger Julia , Palmer Sebastian , Rechmann Johanna , Storz Florian , Walter Bertram , Allard Sarah , Antons Stephanie , Bledzka Marta , Brand Matthias , Dörrenbächer Sandra , Englisch Julia , Friehs Thilo , Da Cunha Gonçalves Katja , Haberkamp Anke , Hall Mila , Kananian Schahryar , Kemmerer Pascal , Klingelhöfer Doerthe , Lutz Wolfgang , Melzig Christiane A. , Michael Tanja , Neumann Anja , Neusser Silke , Niemann Anja , Odenthal Michael , Rubel Julian , Schlierenkamp Sarah , Speckemeier Christian , Ünlü Luisa , Vogt Rabea , Wölfling Klaus , Zachariassen Wiebke , zur Hausen Gerrit , Heinz Christine 
Published: September 2024

AbstractBackgroundThe introduction of Compulsive Sexual Behavior Disorder (CSBD) into the 11th International Classification of Diseases has raised expectations for better treatment options for CSBD. Furthermore, the treatment demand has increased, particularly for pornography use disorder (PUD), a subtype of CSBD. Presumably due to the easy access to Internet pornography an increasing prevalence of PUD is observed. Consequently, providing tailored and effective treatment is essential.MethodsThis article provides an overview of the manualized short-term PornLoS Treatment Program (Pornografienutzungsstörung effektiv behandeln– Leben ohne Suchtdruck; translation: Treating pornography use disorder effectively - life without craving). The program combines 24 individual and 6 group psychotherapy sessions with an interdisciplinary approach by offering a novel treatment framework. This includes, e.g., a mobile app, establishment of self-help groups, and access to other social services such as couple counseling. The cognitive-behavioral treatment program contains interventions addressing psychoeducation, cue exposure, impulse control, cognitive restructuring, emotional regulation, and relapse management.We here also describe the study protocol of an ongoing four-arm randomized controlled trial. The aim is to test two variants of the PornLoS Treatment Program differing with respect to their treatment goal (abstinence or reduced pornography use) against cognitive-behavioral treatment as usual and against a waitlist control group. The primary outcome is the absence of a PUD diagnosis at the end of therapy. The total target sample size will comprise n = 316 patients with PUD across eight study sites.ResultsThe results will be presented at international conferences and published in a scientific peer-reviewed journal.