bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rough gold films as broadband absorbers for plasmonic enhancement of TiO2 photocurrent over 400–800 nm
Authors: Tan Furui , Li Tenghao , Wang Ning , Lai Sin Ki , Tsoi Chi Chung , Yu Weixing , Zhang Xuming 
Published: September 2016

AbstractRecent years have witnessed an increasing interest in highly-efficient absorbers of visible light for the conversion of solar energy into electrochemical energy. This study presents a TiO2-Au bilayer that consists of a rough Au film under a TiO2film, which aims to enhance the photocurrent of TiO2over the whole visible region and may be the first attempt to use rough Au films to sensitize TiO2. Experiments show that the bilayer structure gives the optimal optical and photoelectrochemical performance when the TiO2layer is 30 nm thick and the Au film is 100 nm, measuring the absorption 80–90% over 400–800 nm and the photocurrent intensity of 15 μA·cm−2, much better than those of the TiO2-AuNP hybrid (i.e., Au nanoparticle covered by the TiO2film) and the bare TiO2film. The superior properties of the TiO2-Au bilayer can be attributed to the rough Au film as the plasmonic visible-light sensitizer and the photoactive TiO2film as the electron accepter. As the Au film is fully covered by the TiO2film, the TiO2-Au bilayer avoids the photocorrosion and leakage of Au materials and is expected to be stable for long-term operation, making it an excellent photoelectrode for the conversion of solar energy into electrochemical energy in the applications of water splitting, photocatalysis and photosynthesis.
Low energy electron imaging of domains and domain walls in magnesium-doped lithium niobate
Authors: Nataf G. F. , Grysan P. , Guennou M. , Kreisel J. , Martinotti D. , Rountree C. L. , Mathieu C. , Barrett N. 
Published: September 2016

AbstractThe understanding of domain structures, specifically domain walls, currently attracts a significant attention in the field of (multi)-ferroic materials. In this article, we analyze contrast formation in full field electron microscopy applied to domains and domain walls in the uniaxial ferroelectric lithium niobate, which presents a large 3.8 eV band gap and for which conductive domain walls have been reported. We show that the transition from Mirror Electron Microscopy (MEM – electrons reflected) to Low Energy Electron Microscopy (LEEM – electrons backscattered) gives rise to a robust contrast between domains with upwards (Pup) and downwards (Pdown) polarization, and provides a measure of the difference in surface potential between the domains. We demonstrate that out-of-focus conditions of imaging produce contrast inversion, due to image distortion induced by charged surfaces, and also carry information on the polarization direction in the domains. Finally, we show that the intensity profile at domain walls provides experimental evidence for a local stray, lateral electric field.
Pentoxifylline ameliorates non-alcoholic fatty liver disease in hyperglycaemic and dyslipidaemic mice by upregulating fatty acid β-oxidation
Authors: Ye Jia-Hung , Chao Jung , Chang Ming-Ling , Peng Wen-Huang , Cheng Hao-Yuan , Liao Jiunn-Wang , Pao Li-Heng 
Published: September 2016

AbstractNonalcoholic fatty liver disease (NAFLD), which includes simple steatosis, steatohepatitis, fibrosis, and cirrhosis, is characterised by abnormal fat accumulation in the liver in the absence of excessive alcohol intake. In patients with type 2 diabetes (T2D), concurrent NAFLD might increase the risk of chronic kidney disease and the mortality rate. Although several studies have examined the effectiveness of pentoxifylline (PTX) in NAFLD treatment, no results are available to verify the effectiveness of PTX in treating T2D associated with NAFLD. In this study, we developed a combined high-fat diet-induced obesity and low-dose streptozocin-induced hyperglycaemia mouse model to mimic the concurrent NAFLD and T2D pathological condition. By combining physiological assessments, pathological examinations, metabolomics studies on blood, urine, and liver, and measurements of gene and protein expression, we elucidated the effectiveness and the underlying mechanism of action of PTX in the hyperglycaemic and dyslipidaemic mice. Our results revealed that PTX ameliorated NAFLD in the hyperglycaemic and dyslipidaemic mice by upregulating fatty acid β-oxidation. Furthermore, the glycolysis pathway and branched-chain amino acid-related pathways in these mice were restored by PTX.
Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
Authors: Grindstad Thea , Skjefstad Kaja , Andersen Sigve , Ness Nora , Nordby Yngve , Al-Saad Samer , Fismen Silje , Donnem Tom , Khanehkenari Mehrdad Rakaee , Busund Lill-Tove , Bremnes Roy M. , Richardsen Elin 
Published: September 2016

AbstractAndrogens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays were created from 535 PCa patients treated with radical prostatectomy. Expression of ERα, ERβ and aromatase were evaluated using immunohistochemistry. Representative tumor epithelial (TE) and tumor stromal (TS) areas were investigated separately. Survival analyses were used to evaluate the markers correlation to PCa outcome. In univariate analyses, ERα in TS was associated with delayed time to clinical failure (CF) (p = 0.042) and PCa death (p = 0.019), while ERβ was associated with reduced time to biochemical failure (BF) (p = 0.002). Aromatase in TS and TE was associated with increased time to BF and CF respectively (p = 0.016, p = 0.046). Multivariate analyses supported these observations, indicating an independent prognostic impact of all markers. When stratifying the analysis according to different surgical centers the results were unchanged. In conclusion, significant prognostic roles of ERα, ERβ and aromatase were discovered in the in PCa specimens of our large multicenter cohort.
In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease
Authors: Reggiani Angelo M. , Simoni Elena , Caporaso Roberta , Meunier Johann , Keller Emeline , Maurice Tangui , Minarini Anna , Rosini Michela , Cavalli Andrea 
Published: September 2016

AbstractAlzheimer’s disease (AD) is a chronic pathological condition that leads to neurodegeneration, loss of intellectual abilities, including cognition and memory, and ultimately to death. It is widely recognized that AD is a multifactorial disease, where different pathological cascades (mainly amyloid and tau) contribute to neural death and to the clinical outcome related to the disease. The currently available drugs for AD were developed according to the one-target, one-drug paradigm. In recent times, multi-target strategies have begun to play an increasingly central role in the discovery of more efficacious candidates for complex neurological conditions, including AD. In this study, we report on the in vivo pharmacological characterization of ARN14140, a new chemical entity, which was obtained through a multi-target structure-activity relationship campaign, and which showed a balanced inhibiting profile against the acetylcholinesterase enzyme and the NMDA receptor. Based on the initial promising biochemical data, ARN14140 is here studied in mice treated with the amyloidogenic fragment 25–35 of the amyloid-β peptide, a consolidated non-transgenic AD model. Sub-chronically treating animals with ARN14140 leads to a prevention of the cognitive impairment and of biomarker levels connected to neurodegeneration, demonstrating its neuroprotective potential as new AD agent.
Ultrasound-targeted microbubble destruction enhances delayed BMC delivery and attenuates post-infarction cardiac remodelling by inducing engraftment signals
Authors: Chen Yanmei , Zhang Chuanxi , Shen Shuxin , Guo Shengcun , Zhong Lintao , Li Xinzhong , Chen Guojun , Chen Gangbin , He Xiang , Huang Chixiong , He Nvqin , Liao Wangjun , Liao Yulin , Bin Jianping 
Published: September 2016

Delayed administration of bone marrow cells (BMCs) at 2–4 weeks after successful reperfusion in patients with acute myocardial infarction (MI) does not improve cardiac function. The reduction in engraftment signals observed following this time interval might impair the effects of delayed BMC treatment. In the present study, we aimed to determine whether ultrasound-targeted microbubble destruction (UTMD) treatment could increase engraftment signals, enhance the delivery of delayed BMCs and subsequently attenuate post-infarction cardiac remodelling. A myocardial ischaemia/reperfusion (I/R) model was induced in Wistar rats via left coronary ligation for 45 min followed by reperfusion. Western blotting revealed that engraftment signals peaked at 7 days post-I/R and were dramatically lower at 14 days post-I/R. The lower engraftment signals at 14 days post-I/R could be triggered by UTMD treatment at a mechanical index of 1.0–1.9. The troponin I levels in the 1.9 mechanical index group were higher than in the other groups. Simultaneous haematoxylin and eosin staining and fluorescence revealed that the number of engrafted BMCs in the ischaemic zone was greater in the group treated with both UTMD and delayed BMC transplantation than in the control groups (P&lt;0.05). Both UTMD and delayed BMC transplantation improved cardiac function and decreased cardiac fibrosis at 4 weeks after treatment, as compared with control groups (both P&lt;0.05). Histopathology demonstrated that UTMD combined with delayed BMC transplantation increased capillary density, myocardial cell proliferation and c-kit+ cell proliferation. These findings indicated that UTMD treatment could induce engraftment signals and enhance homing of delayed BMCs to ischaemic myocardium, attenuating post-infarction cardiac remodelling by promoting neovascularization, cardiomyogenesis and expansion of cardiac c-kit+ cells.
Effect of bremsstrahlung radiation emission on fast electrons in plasmas
Authors: Embréus O , Stahl A , Fülöp T 
Published: September 2016

Abstract
Bremsstrahlung radiation emission is an important energy loss mechanism for energetic electrons in plasmas. In this paper we investigate the effect of spontaneous bremsstrahlung emission on the momentum−space structure of the electron distribution, fully accounting for the emission of finite−energy photons by modeling the bremsstrahlung interactions with a Boltzmann collision operator. We find that electrons accelerated by electric fields can reach significantly higher energies than predicted by the commonly used radiative stopping−power model. Furthermore, we show that the emission of soft photons can contribute significantly to the dynamics of electrons with an anisotropic distribution by causing pitch−angle scattering at a rate that increases with energy.
Efficiency of perfectly matched layers for seismic wave modeling in second-order viscoelastic equations
Authors: Ping Ping , Zhang Yu , Xu Yixian , Chu Risheng 
Published: September 2016

Summary
In order to improve the perfectly matched layer (PML) efficiency in viscoelastic media, we first propose a split multi-axial PML (M-PML) and an unsplit convolutional PML (C-PML) in the second-order viscoelastic wave equations with the displacement as the only unknown. The advantage of these formulations is that it is easy and efficient to revise the existing codes of the second-order spectral element method (SEM) or finite-element method (FEM) with absorbing boundaries in a uniform equation, as well as more economical than the auxiliary differential equations PML. Three models which are easily suffered from late time instabilities are considered to validate our approaches. Through comparison the M-PML with C-PML efficiency of absorption and stability for long time simulation, it can be concluded that: (1) for an isotropic viscoelastic medium with high Poisson's ratio, the C-PML will be a sufficient choice for long time simulation because of its weak reflections and superior stability; (2) unlike the M-PML with high-order damping profile, the M-PML with second-order damping profile loses its stability in long time simulation for an isotropic viscoelastic medium; (3) in an anisotropic viscoelastic medium, the C-PML suffers from instabilities, while the M-PML with second-order damping profile can be a better choice for its superior stability and more acceptable weak reflections than the M-PML with high-order damping profile. The comparative analysis of the developed methods offers meaningful significance for long time seismic wave modeling in second-order viscoelastic wave equations.
The Japan Lung Cancer Society–Japanese Society for Radiation Oncology consensus-based computed tomographic atlas for defining regional lymph node stations in radiotherapy for lung cancer
Authors: Itazawa Tomoko , Tamaki Yukihisa , Komiyama Takafumi , Nishimura Yasumasa , Nakayama Yuko , Ito Hiroyuki , Ohde Yasuhisa , Kusumoto Masahiko , Sakai Shuji , Suzuki Kenji , Watanabe Hirokazu , Asamura Hisao 
Published: September 2016

Abstract
The purpose of this study was to develop a consensus-based computed tomographic (CT) atlas that defines lymph node stations in radiotherapy for lung cancer based on the lymph node map of the International Association for the Study of Lung Cancer (IASLC). A project group in the Japanese Radiation Oncology Study Group (JROSG) initially prepared a draft of the atlas in which lymph node Stations 1–11 were illustrated on axial CT images. Subsequently, a joint committee of the Japan Lung Cancer Society (JLCS) and the Japanese Society for Radiation Oncology (JASTRO) was formulated to revise this draft. The committee consisted of four radiation oncologists, four thoracic surgeons and three thoracic radiologists. The draft prepared by the JROSG project group was intensively reviewed and discussed at four meetings of the committee over several months. Finally, we proposed definitions for the regional lymph node stations and the consensus-based CT atlas. This atlas was approved by the Board of Directors of JLCS and JASTRO. This resulted in the first official CT atlas for defining regional lymph node stations in radiotherapy for lung cancer authorized by the JLCS and JASTRO. In conclusion, the JLCS–JASTRO consensus-based CT atlas, which conforms to the IASLC lymph node map, was established.
Influence of Duration of Heroin Dependence on Humoral Immunologic Indicators
Authors: Simonovska Natasha , Zafirova-Ivanovska Beti , Babulovska Aleksandra , Pereska Zanina , Jurukov Irena , Trenchevska-Siljanovska Liljana 
Published: September 2016

Objective:
The incidence of autoantibodies may be associated with the duration of drug use. In this study, we assessed the association between the duration of heroin dependence and various humoral immunologic indicators, including IgA, IgG, IgM, complement component 3, complement component 4, rheumatoid factor, anti-β2-glycoprotein 1 (IgA, IgG, IgM), antinuclear antibody, circulating immune complexes, and cryoglobulins.

Methods:
A total of 363 patients with heroin dependence were enrolled in this cross-sectional and prospective study over a 3.5-year period. Depending on the duration of heroin use, participants were divided into 3 groups: up to 3 years, 4 to 7 years, and more than 7 years of heroin dependence. All patients were analyzed for the indicators.

Results:
There was a significant difference between the duration of heroin dependence and increased concentration of IgA (P = 0.0000), IgG (P = 0.0000), IgM (P = 0.0001), complement component 3 (P = 0.042), rheumatoid factor (P = 0.0001), anti-β2-glycoprotein 1 (IgA, P = 0.0098; IgG, P = 0.0000; IgM, P = 0.0000), the presence of antinuclear antibody (P = 0.01) and cryoglobulins (P = 0.0000), and decreased concentration of complement component 4 (P = 0.002). There was no significant difference in circulating immune complex concentration (P = 0.097).

Conclusions:
A longer duration of heroin dependence was associated with increased concentrations of IgA, IgG, IgM, complement component 3, rheumatoid factor, anti-β2-glycoprotein 1 (IgA, IgG, IgM), presence of antinuclear antibodies and cryoglobulins, and decreased concentrations of complement component 4, but there was no influence on circulating immune complex values.
Rural Patients With Severe Sepsis or Septic Shock Who Bypass Rural Hospitals Have Increased Mortality: An Instrumental Variables Approach*
Authors: Mohr Nicholas M. , Harland Karisa K. , Shane Dan M. , Ahmed Azeemuddin , Fuller Brian M. , Ward Marcia M. , Torner James C. 
Published: September 2016

Objective:
To identify factors associated with rural sepsis patients’ bypassing rural emergency departments to seek emergency care in larger hospitals, and to measure the association between rural hospital bypass and sepsis survival.

Design:
Observational cohort study.

Setting:
Emergency departments of a rural Midwestern state.

Patients:
All adults treated with severe sepsis or septic shock between 2005 and 2014, using administrative claims data.

Interventions:
Patients bypassing local rural hospitals to seek care in larger hospitals.

Measurements and Main Results:
A total of 13,461 patients were included, and only 5.4% (n = 731) bypassed a rural hospital for their emergency department care. Patients who initially chose a top-decile sepsis volume hospital were younger (64.7 vs 72.7 yr; p < 0.001) and were more likely to have commercial insurance (19.6% vs 10.6%; p < 0.001) than those who were seen initially at a local rural hospital. They were also more likely to have significant medical comorbidities, such as liver failure (9.9% vs 4.2%; p < 0.001), metastatic cancer (5.9% vs 3.2%; p < 0.001), and diabetes with complications (25.2% vs 21.6%; p = 0.024). Using an instrumental variables approach, rural hospital bypass was associated with a 5.6% increase (95% CI, 2.2–8.9%) in mortality.

Conclusions:
Most rural patients with sepsis seek care in local emergency departments, but demographic and disease-oriented factors are associated with rural hospital bypass. Rural hospital bypass is independently associated with increased mortality.
Nursing in the Mercy Traditions
Authors: Kwasky Andrea , Corrigan Catherine 
Published: September 2016

ABSTRACT:
The Institute of Medicine and the American Association of Colleges of Nursing advise that professional nursing education include development of a high level of cultural competency. A 10-day learning experience to Ireland for nursing students at the University of Detroit Mercy, an independent Catholic university, sponsored by the Sisters of Mercy and the Society of Jesus (Jesuit Fathers), helped them develop a philosophy of Mercy care and build cultural competence. Learning focused on the life of Catherine McAuley, Irish culture, spirituality, social justice, reflective thinking, and a value-centered professional education.
Tetrodotoxin-sensitive Ca2+ Currents, but No T-type Currents in Normal, Hypertrophied, and Failing Mouse Cardiomyocytes
Authors: Bodi Ilona , Nakayama Hiroyuki , Schwartz Arnold 
Published: September 2016

Aims:
To obtain functional evidence that ICa,T is involved in the pathogenesis of cardiac hypertrophy and heart failure. We unexpectedly identified ICa(TTX) rather than ICa,T, therefore, we adjusted our aim to encompass these findings.

Methods and Results:
We investigated (1) Cav3.1 (α1G) transgenic (Tg) mice compared with nontransgenic (tTA-Ntg); (2) Cav3.1-deficient mice (Cav3.1−/−) compared with wild type (Wt) after chemically and surgically induced cardiac remodeling; and (3) spontaneous hypertensive rats and thoracic aortic constriction (TAC) rats. Whole-cell patch-clamp technique was used to measure ICa in ventricular myocytes. Cav3.1-Tg expressed ICa,T (−18.35 ± 1.02 pA/pF at −40 mV) without signs of compromised cardiac function. While we failed to detect ICa,T after hypertrophic stimuli, instead we demonstrated that both Wt and Cav3.1−/− mouse exhibit ICa(TTX). Using TAC rats, only 2 of 24 VMs showed ICa,T under our experimental conditions. Without TTX, ICa(TTX) occurred in VMs from Wt, spontaneous hypertensive rats, and TAC rats also.

Conclusions:
These findings demonstrate for the first time that mouse VMs express ICa(TTX). We suggest that future studies should take into consideration the measuring conditions when interpreting ICa,T reappearance in ventricular myocytes in response to hypertrophic stress. Contamination with ICa(TTX) could possibly confuse the relevance of the data.
Avoiding a Systematic Error in Assessing Fat Graft Survival in the Breast with Repeated Magnetic Resonance Imaging
Authors: Glovinski Peter V. , Herly Mikkel , Müller Felix C. , Elberg Jens J. , Kølle Stig-Frederik T. , Fischer-Nielsen Anne , Thomsen Carsten , Drzewiecki Krzysztof T. 
Published: September 2016

Summary:
Several techniques for measuring breast volume (BV) are based on examining the breast on magnetic resonance imaging. However, when techniques designed to measure total BV are used to quantify BV changes, for example, after fat grafting, a systematic error is introduced because BV changes lead to contour alterations of the breast. The volume of the altered breast includes not only the injected volume but also tissue previously surrounding the breast. Therefore, the quantitative difference in BV before and after augmentation will differ from the injected volume. Here, we present a new technique to measure BV changes that compensates for this systematic error by defining the boundaries of the breast to immovable osseous pointers. This approach avoids the misinterpretation of tissue included within the expanded boundaries as graft tissue. This new method of analysis may be a reliable tool for assessing BV changes to determine fat graft retention and may be useful for evaluating and comparing available surgical techniques for breast augmentation and reconstruction using fat grafting.
The potent, indirect adenosine monophosphate-activated protein kinase activator R419 attenuates mitogen-activated protein kinase signaling, inhibits nociceptor excitability, and reduces pain hypersensitivity in mice
Authors: Mejia Galo L. , Asiedu Marina N. , Hitoshi Yasumichi , Dussor Gregory , Price Theodore J. 
Published: September 2016

Abstract
There is a great need for new therapeutics for the treatment of pain. A possible avenue to development of such therapeutics is to interfere with signaling pathways engaged in peripheral nociceptors that cause these neurons to become hyperexcitable. There is strong evidence that mitogen-activated protein kinases and phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin signaling pathways are key modulators of nociceptor excitability in vitro and in vivo. Activation of adenosine monophosphate-activated protein kinase (AMPK) can inhibit signaling in both of these pathways, and AMPK activators have been shown to inhibit nociceptor excitability and pain hypersensitivity in rodents. R419 is one of, if not the most potent AMPK activator described to date. We tested whether R419 activates AMPK in dorsal root ganglion (DRG) neurons and if this leads to decreased pain hypersensitivity in mice. We find that R419 activates AMPK in DRG neurons resulting in decreased mitogen-activated protein kinase signaling, decreased nascent protein synthesis, and enhanced P body formation. R419 attenuates nerve growth factor (NGF)-induced changes in excitability in DRG neurons and blocks NGF-induced mechanical pain amplification in vivo. Moreover, locally applied R419 attenuates pain hypersensitivity in a model of postsurgical pain and blocks the development of hyperalgesic priming in response to both NGF and incision. We conclude that R419 is a promising lead candidate compound for the development of potent and specific AMPK activation to inhibit pain hypersensitivity as a result of injury.