bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA‐223 alleviates inflammatory response in renal ischemia‐reperfusion injury by targeting NLRP3
Authors: Ye Jun , Tang Xiaoli , Li Ming , Liao Yutian , Zeng Yiqian , Tang Furong , Qiu Eryue 
Published: September 2024

AbstractWe investigated the potential correlation between miR‐223 and NAcHT, LRR, and PYd domain‐containing protein 3 (NLRP3) in the context of renal ischemia‐reperfusion injury (RIRI), which is a leading cause of acute renal failure with significant mortality rates. Additionally, miR‐223 has been implicated in renal inflammation, further highlighting its relevance to this study. C57BL/6 male mice were used as RIRI models. After successful modeling, pathological examinations and serum creatinine and miR‐223 levels were tested. Pro‐inflammatory cytokine (IL‐1β, IL‐6, IL‐8, NLPR3, TLR4) expression was detected in mice by western blot (kidney tissue) and enzyme‐linked immunosorbent assay (serum). HK‐2 cells were used for in vitro experiments. A hypoxia/reoxygenation (H/R) model was used, and miR‐223 and pro‐inflammatory cytokine levels were detected using PCR and western blot assays, respectively. A dual‐luciferase reporter assay was conducted to confirm the binding of miR‐223 to NLPR3. Next, NLRP3 was knocked down to determine whether the anti‐inflammatory function of miR‐223 is dependent on NLRP3. MiR‐223 expression was lower in RIRI mice than in the sham operation group. The level of miR‐223 negatively correlated with serum creatinine levels and the severity of tubule injury. Increased proinflammatory cytokine levels in RIRI mice were observed. In vitro, miR‐223 alleviated the inflammatory response in H/R treated cells by inhibiting proinflammatory cytokines. Dual‐luciferase reporter and western blot assays confirmed the binding of miR‐223 to NLRP3. NLRP3 knockdown reversed the anti‐inflammatory effects of miR‐223 in HK‐2 cells. MiR‐223 plays an anti‐inflammatory role in RIRI by targeting NLRP3 to repress pro‐inflammatory factors.
The release of GLP‐1 from gut L cells is inhibited by low extracellular pH
Authors: Garbutt Philippa , Cyranka Malgorzata , Michl Johanna , Maejima Yuko , Vedovato Natascia , Shimomura Kenju , Swietach Pawel , de Wet Heidi 
Published: September 2024

AbstractObjectiveThe intestinal luminal pH profile varies from stomach to rectum and becomes disrupted in diseases. However, little is known about the pH dependence of incretin hormone secretion, with most in vitro studies having failed to consider this modulatory factor or having used nonphysiological buffer systems. Here, we report the extracellular pH (pHe) dependence of glucagon‐like peptide‐1 (GLP‐1) exocytosis from L cells.MethodsThe pHe dependence of GLP‐1 release from GLUTag cells and murine ex vivo primary gut cultures was detected by ELISA. GLP‐1 release was measured over a range of pHe under a physiological (CO2/HCO3−) buffering regime and in its absence (HEPES buffer). The relationship between intracellular pH (pHi) and pHe was mapped given that at least some component of pH sensitivity is likely to be intracellular.ResultsGLP‐1 secretion from L cells was pHe‐dependent and stimulated under alkaline conditions. In the absence of glucose or extracellular calcium, secretion remained at a pHe‐insensitive baseline. pHi followed changes in pHe, but the relationship was offset to more alkaline levels in the absence of CO2/HCO3− buffer and became shallower if [Cl−] changes that normally accompany [HCO3−] changes were compensated iso‐osmotically with gluconate.ConclusionsGLP‐1 secretion is sensitive to pHe and the buffer present. Exploiting this mechanism therapeutically may benefit patients with obesity.
Extreme temperature influence on low velocity impact damage and residual flexural properties of CFRP
Authors: Bavasso Irene , Sergi Claudia , Ferrante Luca , Pawlik Marzena , Lu Yiling , Lampani Luca , Tirillò Jacopo , Sarasini Fabrizio 
Published: September 2024

AbstractIn this work, the behavior of carbon fiber reinforced polymer composites (CFRPs) interleaved with electrospun veils under low velocity impact (LVI) conditions and extreme environmental temperatures was investigated. 2/2 twill carbon fiber/epoxy laminates were subjected to LVI at three energy levels (10, 20, and 30 J), and three temperatures (−50°C, room temperature, and 100°C). Two interleaved configurations were explored (six veils placed symmetrically with respect to the middle plane of the laminate and with respect to the external layers of the laminate). Particularly at room temperature and up to 20 J, nanofibrous interlayers effectively reduced localized deformation (by about 13.0%) and delamination (by about 12.2%) when positioned in the outer ply interleaved configuration compared to the reference laminate. At 100°C, this effect is maintained at 10 J, preventing an increase in the delaminated area. At −50°C and 10 J, the promotion of delamination prevented back surface fiber failure. Regarding post‐impact flexural properties, the presence of nanoveils ensured superior mechanical properties compared to the corresponding reference laminate impacted at the same conditions, demonstrating their efficacy in enhancing the damage tolerance of the overall laminate.Highlights
Electrospun veils were interleaved in 20 layers of 2/2 twill carbon/epoxy laminate.
Three configurations were tested under LVI at 10 J, 20 J, 30 J, and −50°C, RT, and 100°C.
Observed damage modes include delamination, indentation, and back surface fiber cracks.
Veils symmetrically placed in external layers limit delamination at 20 J (RT) and 10 J (100°C).
Electrospun veils enhanced CFRP bending and residual post‐impact properties at RT and 100°C.
Detecting and Dating Early Non‐live Pregnancy Outcomes: Generation of a Novel Pregnancy Algorithm From Norwegian Linked Health Registries
Authors: Nordeng Hedvig , Lupattelli Angela , Engjom Hilde M. , van Gelder Marleen M. H. J. 
Published: September 2024

ABSTRACTPurposePregnancies ending before gestational week 12 are common but not notified to the Medical Birth Registry of Norway. Our goal was to develop an algorithm that more completely detects and dates all possible pregnancy outcomes (i.e., miscarriages, elective terminations, ectopic pregnancies, molar pregnancies, stillbirths, and live births) by using diagnostic codes from primary and secondary care registries to complement information from the birth registry.MethodsWe used nationwide linked registry data between 2008 and 2018 in a hierarchical manner: We developed the UiO pregnancy algorithm to arrive at unique pregnancy outcomes, considering codes within 56 days as the same event. To estimate the gestational age of pregnancy outcomes identified in the primary and secondary care registries, we inferred the median gestational age of pregnancy markers (45 ICD‐10 codes and 9 ICPC‐2 codes) from pregnancies registered in the medical birth registry. When no pregnancy markers were available, we assigned outcome‐specific gestational age estimates. The performance of the algorithm was assessed by blinded clinicians.ResultsUsing only the medical birth registry, we identified 649 703 pregnancies, including 1369 (0.2%) miscarriages and 3058 (0.5%) elective terminations. With the new algorithm, we detected 859 449 pregnancies, including 642 712 live‐births (74.8%), 112 257 miscarriages (13.1%), 94 664 elective terminations (11.0%), 6429 ectopic pregnancies (0.7%), 2564 stillbirths (0.3%), and 823 molar pregnancies (0.1%). The median gestational age was 10+1 weeks (IQR 10+0–12+2) for miscarriages and 8+0 weeks (IQR 8+0–9+6) for elective terminations. Gestational age could be inferred using pregnancy markers for 66.3% of miscarriages and 47.2% of elective terminations.ConclusionThe UiO pregnancy algorithm improved the detection and dating of early non‐live pregnancy outcomes that would have gone unnoticed if relying solely on the medical birth registry information.
One‐step electrosynthesis of a nanocomposite of functionalized graphene and polypyrrole for enhanced room‐temperature nitrogen oxide sensing
Authors: Guettiche Djamil , Mekki Ahmed , Debiemme‐Chouvy Catherine , Simon Nathalie , Sayah Zakaria Bekkar Djelloul , Tighilt Fatma‐Zohra , Touijine Sabri , Mansri Omar 
Published: September 2024

AbstractDue to the numerous challenges related to selectivity, sensitivity, stability, and operation at standard room temperature, improving the environmental detection of nitrogen oxide presents a considerable defy in the development of novel promising structures in chemical detection. In this study, a new series of p‐type heterojunction nanocomposites based on electrodeposited polypyrrole (PPy) doped with n‐dodecylbenzene sulphonate and either reduced graphene oxide (PPy/RedGO) or reduced graphene oxide functionalized using aryl 4‐carboxybenzene diazonium salt (PPy/RedGO‐arylCOOH) was synthetized using a one‐step chronoamperometric process. The influence of functionalized graphene incorporation on the structural, morphological, and sensory performances of the PPy film was investigated. Its sensitivity and reactivity to NO2 sensing were studied. The structural data confirms that PPy/RedGO‐arylCOOH film is a homogeneous nanocomposite with improved crystalline ordering. It shows optimal NO2 sensing properties compared to the PPy/RedGO composite in terms of sensitivity (0.87 ppm−1), detection limit (2 ppm), response time of 29 s, recovery time of 40 s and reproducibility at room temperature.
Preparation of poly(3‐hexylthiophene) conjugated polymer brush films from amine‐terminated surfaces
Authors: Armendarez Olivia J. , Parizek Grace C. , Augustine Ruth J. , Silver Evan J. , Kaz Tristan A. , Campbell Kaylee A. , Diaz Isabella P. , Mantripragada Shobha , Geil Robert D. , Flagg Sadie M. , Augustine Brian H. , Lundin Pamela M. 
Published: September 2024

AbstractConjugated polymer brush (CPB) films are more robust and exhibit more vertically aligned polymer chains than their spun‐cast analogs. We prepare CPB films of poly(3‐hexylthiophene) (P3HT) by coupling an amine‐terminated surface (ATS) formed from (3‐aminopropyl)triethoxysilane (APTES) on Si/SiO2 to 4‐bromobenzoic acid using standard, inexpensive peptide coupling reagents. The resulting terminal bromobenzene is reacted with Pd(PtBu3)2 and immersed in the monomer solution. X‐ray photoelectron spectroscopy, spectroscopic ellipsometry and static water contact angle measurements confirm the surface chemistry at each stage of P3HT CPB preparation. Atomic force microscopy(AFM) and UV–vis spectrophotometry indicate that the CPB films prepared by this method exhibit similar morphology and optical properties to those produced from other methods of poly(3‐alkylthiophene) CPB film preparation. Variations of the standard approach, such as using a pre‐synthesized silane counterpart or with (11‐aminoundecyl)triethoxysilane, show comparable film morphologies by AFM. This method is used to produce the first CPB film of poly(3‐dodecylthiophene), showing its utility for exploring CPB films of more sterically demanding polymers. Peptide coupling is used to prepare an analogous functionalized thiol for initiating P3HT CPB film growth from Au surfaces, and microcontact printing with this thiol allows preparation of the first patterned CPB film of P3HT.
Diagnosis and treatment of ADHD in pediatric patients during the first year of elexacaftor/tezacaftor/ivacaftor
Authors: Pasley Kimberly , Dell Mary Lynn , May Anne 
Published: September 2024

AbstractBackgroundWith elexacaftor/tezacaftor/ivacaftor (ETI), children with cystic fibrosis (CwCF) are living healthier lives with a focus on typical developmental issues such as attention deficit/hyperactivity disorder (ADHD). This paper characterizes CwCF with ADHD within the first year of ETI treatment.MethodsThis retrospective, observational analysis examines a subgroup of CwCF participating in a longitudinal study obtaining prospective data regarding the impact of ETI on mental health. All participants started on ETI were offered enrollment, with rolling enrollment as younger children became eligible. Clinical data regarding CF symptoms, mental health diagnoses, medications, changes in mental health symptoms and BMI were collected via chart review.ResultsBefore ETI, ADHD diagnoses were identified in 21 children; an additional 3 were diagnosed within the first year. Eleven children were treated with ADHD medication at ETI initiation; nine children did not use ADHD medication during the study period. In the 1‐year follow‐up, four children started ADHD medication. Of the 11 who started ETI on ADHD medication, five increased doses, three changed medications and/or decreased dose, and one discontinued medication. Two children experienced no changes to their treatment.ConclusionMost CwCF on ADHD medication underwent changes in dosing and/or medication after ETI initiation. Several children were diagnosed with ADHD after starting ETI. The role of ETI in these recent diagnoses and treatment plans is unclear. Given the prevalence of pediatric ADHD diagnoses and the medication changes that were needed by this population, additional research is warranted to clarify the relationship between ETI and ADHD in CwCF.
Complete removal of a ruptured pulmonary hydatid cyst during conscious sedation bronchoscopy: A case report and literature review
Authors: Wen Kevin Ziyi , Lim Ricky Tanujaya , Dimitri Andrew , Noonan Lisa , Williamson Jonathan 
Published: September 2024

AbstractThe complete removal of a pulmonary hydatid cyst by bronchoscopy occurs rarely in clinical practice. We describe a 22‐year‐old male originally from Lebanon, with suspected hydatid cyst rupture on computed tomography chest after experiencing sudden onset fevers and cough whilst taking empiric anthelmintic therapy. Bronchoscopy revealed white gelatinous material in the posterior segment of the left lower lobe. The complete membranes of a hydatid cyst were removed with grasping forceps. Histologic examination confirmed the diagnosis of echinococcosis.
Room Temperature Single‐Component Organic Multiferroics with Large Magnetoelectric Coupling: Proficient Approach for Stray‐Magnetic Field Harvesting
Authors: Deepak  , Saini Dalip , Naskar Sudip , Mandal Dipankar , Roy Raj Kumar 
Published: September 2024

AbstractMagnetoelectric materials are highly desirable for technological applications due to their ability to produce electricity under a magnetic field. Among the various types of magnetoelectric materials studied, their organic counterparts provide an opportunity to develop solution‐processable, flexible, lightweight, and wearable electronic devices. However, there is a rare choice of solution‐processable, flexible, lightweight magnetoelectric materials which has tremendous technological interest. A supramolecular scaffold with precisely positioned structure‐forming and functional units (electrical dipoles and magnetic spins) is designed so that self‐assembly results in functional unit organization. Structure‐forming segments allow these scaffolds to self‐assemble into hierarchically ordered structures in nonpolar solvents, creating nanofibrous organogel networks. In particular, the xerogel derived from this organogel exhibits the highest magnetoelectric coupling coefficient (αME ≈ 216 mV Oe−1 cm−1) reported to date for organic materials. This is even greater than commonly envisioned composite materials made of piezoelectric polymers and inorganic magnets. This single‐component organic multiferroic material displays ferroelectricity (Tc ≈ 46 °C) and paramagnetic behavior at room temperature. With this, it is demonstrated that the possibilities of effectively harvesting stray magnetic fields that are copiously available in the surroundings and wasted otherwise.
Empirical Confirmation of Theoretical Predictions for Amorphous H/VO4 Cathodes: Advancing Durability and Efficiency in Zinc‐Ion Batteries
Authors: Zhang Yu , Wang Zhiwen , Ye Hang , Wei Mengdong , Gu Yaoyu , Qu Shaojie , Wang Yang , Hu Kuan , Zhao Junqi , Liu Chunsheng , Jia Dianzeng , Lin He 
Published: September 2024

AbstractAdvancing cathode materials is crucial for the broader application of aqueous zinc‐ion batteries (ZIBs) in energy storage systems. This study presents amorphous H/VO4 (HVO), a novel cathode material engineered by substituting H+ for Mg2+ in Mg2VO4 (MgVO), designed to enhance performance of ZIBs. Initial exploration of MgVO through ab initio molecular dynamics (AIMD) simulations and density functional theory (DFT) calculations revealed a favorable Mg2+ and Zn2+ exchange mechanism. This mechanism notably reduces electrostatic interactions and facilitates ion diffusion within the host lattice. Building upon these findings, in this work, theoretical calculations analysis indicated that amorphous HVO offers a higher diffusion coefficient for Zn2+ ions and fewer electrostatic interactions compared to its crystalline MgVO precursor. Subsequent empirical validation is achieved by synthesizing amorphous HVO using a rapid ion‐exchange process, effectively replacing Mg2+ with H+ ions. The synthesized amorphous HVO demonstrated 100% capacity retention after 18000 cycles at a current density of 2 A g−1 and exhibited exceptional rate performance. These findings underscore the significant potential of HVO cathodes to enhance the durability and efficiency of aqueous ZIBs, positioning them as promising candidates for future energy storage technologies.
Bidirectional Inhibiting Interfacial Ion Migration in the Inorganic Hole Transport Layer for Perovskite Light‐Emitting Diodes
Authors: Pan Lunyao , Zeng Xiankan , Qu Yuanxiao , Mu Maolin , Yang Shiyu , Chen Yongjian , Li Chenglong , Dai Linzhu , Tao Li , Xin Hongqiang , Li Wen , Yang Weiqing 
Published: September 2024

AbstractCu2ZnSnS4 (CZTS) is strong candidate for hole transport in perovskite light emitting diodes (PeLEDs) due to their cost‐effectiveness, deep highest occupied molecular orbital (HOMO), and high hole mobility. However, its inherent polymetallic ions usually deteriorate the quality of the perovskite emission layer (EML) affecting device performance. In this study, a bidirectional anchoring strategy is proposed by adding 15‐crown‐5 ether (15C5) into CZTS hole transport layer (HTL) to suppress the reaction between HTL and EML. The 15C5 molecule interacts with Cu+, Zn2+ and Sn2+ cations forming host–guest complexes to impede their migration, which is elucidated by density functional theory calculations. Additionally, 15C5 can neutralize lead (Pb) defects by the abundant oxygen (O) and high electronegative cavities to reduce the nonradiative recombination of FAPbBr3 film. This bidirectional anchoring strategy effectively improves hole charge transport efficiency and suppresses nonradiative recombination at the HTL/EML interface. As a result, the optimized PeLEDs present a 3.5 times peak external quantum efficiency (EQE) from 3.12% to 11.08% and the maximum luminance (Lmax) increased from 24495 to 50584 cd m−2. These findings offer innovative insights into addressing the metal ion migration issue commonly observed in inorganic HTLs.
Seismic performance of joint between steel H‐beam and rectangular concrete‐filled hot‐rolled‐steel tubular column
Authors: Wang Hanqin , Jiang Qing , Huang Zhipeng , Huang Junqi , Chong Xun 
Published: September 2024

AbstractIn this paper, a new connection between the H‐beam and rectangular concrete‐filled hot‐rolled‐steel tubular column (CFHRSTC) was proposed to prevent the steel beam‐column joint protruded from the inside wall in residential buildings. The quasi‐static test and finite element analysis were conducted on four new joints to study the influence of the haunch stiffener configuration, internal steel plate thickness, and axial force on the failure mode, load‐carrying capacity, ductility, energy dissipating capacity, and stiffness degradation of the joint. The results revealed that the hysteretic curve of every joint was full. The damage to the joint was concentrated in the H‐beam, and the CFHRSTC remained elastic. The joint configuration could realize a weak beam‐strong column and joint core connection. Using the haunch stiffener on two sides of the H‐beam flange could effectively optimize load transfer at the end of the H‐beam and joint core. As the axial force increased, the ultimate load‐carrying capacity and ductility gradually decreased. Reducing the thickness of the internal steel plate did not significantly influence the seismic performance of the joint. Compared with the use of cover plate joints, the use of haunch stiffeners can effectively enhance the seismic performance of joints.
Study of People's Behavior on the Implementation of Air Pollution Mitigation Program in Surabaya, Indonesia
Authors: Irsyada Widya Sagita , Gustinasari Kiki , Hermana Joni 
Published: September 2024

ABSTRACTThe effectiveness of the air pollution mitigation program implementation to reduce CO2 emissions in Surabaya, Indonesia, has not been recognized because there are no studies on the influence of people's behavior toward air pollution mitigation programs yet. Thus, this research examined the influence of people's behavior toward the air pollution mitigation program to calculate the effectiveness of the mitigation program on CO2 reduction and assess the most effective air pollution mitigation program. The research was conducted based on a questionnaire survey of 100 respondents from 31 sub‐districts in Surabaya. Mitigation programs studied were liquid petroleum gas (LPG) conversion, biodiesel conversion, car‐free day, P and P system (emission test and vehicle periodic maintenance), composting, and reduction of plastic usage. The correlation analysis method was used to analyze the data. Based on the results of the analysis, LPG was the most influential program that affected people's behavior because it was mostly implemented by 92% of respondents. The CO2 emission was reduced to 66.38% by implementing the air pollution mitigation program. The most effective mitigation program was the P and P system.
Transdisziplinäre Experimentierräume als Forschungsstrategien in der Mobilitätswende
Authors: Haus Juliane 
Published: September 2024

ZusammenfassungTransdisziplinäre Forschungsformate, allen voran Reallabore, die gezielt weitere gesellschaftliche Akteursgruppen aus Politik, Verwaltung, Wirtschaft und Zivilgesellschaft einbeziehen, gewinnen stetig an Bedeutung. Ihr entscheidendes Potenzial liegt in der ko-produktiven Generierung von Ziel- und Transformationswissen durch die lösungsorientierte Zusammenarbeit heterogener Akteure. Transdisziplinäre Experimentierräume sind eine spezifische Form von Reallaboren, die Orte hervorbringen, an denen Alternativen erlebt und erprobt werden können. Sie produzieren empirische Anstöße für Irritationen tradierter Handlungsroutinen, schaffen neue Möglichkeits- und Erfahrungsräume und machen Konfliktarenen analysierbar. Sie bieten dabei vielfältige Chancen für einen bi-direktionalen Wissenstransfer zwischen Wissenschaft und Praxis. Kommunen bilden die Orte der Umsetzung von Experimentierräumen im Mobilitätsbereich. Die Betrachtung zentraler Rahmenbedingungen in Kommunen (z. B. rechtliche Handlungsspielräume und Ressourcen), erlaubt ein tieferes Verständnis für Herausforderungen und Potenziale der transdisziplinären Zusammenarbeit. Experimentierräume schaffen hierbei nicht nur empirische Zugänge zu relevanten Forschungsthemen, sondern geben zugleich vielfältige Anstöße für eine kritische Reflexion der Rolle von Wissenschaft bei der Bewältigung der anstehenden Transformationsherausforderungen.
Summary and Policy Recommendations
Authors: Hardman Frank 
Published: September 2024

AbstractA common trend emerging from the four country case studies has been the need to broaden the focus of educational development in rural communities from improving access to improving the quality of education and that teachers are at the heart of such improvements. While all four case studies show significant gains have been made in improving access to education in developing countries since the launch of Education for All (EFA), there remain significant challenges for improving the quality of education once the students are in the schools, particularly in rural areas.