bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal and paternal harsh parenting and anxiety symptoms in Chinese adolescents: examining a multiple mediation model
Authors: Yang Xiujuan , Lin Ling , Feng Wen , Liu Pei , Liang Nana , Xue Zhenpeng , Ma Yuejiao , Shen Yuan , Yu Wenwen , Lu Jianping , Liu Jianbo 
Published: October 2024

Abstract
Background
Harsh parenting has been recognized as a risk factor for adolescent anxiety; however, the underlying mechanisms of this relationship remain unclear, and it is unknown whether this relationship is influenced by different parental roles and living arrangements. This study aimed to investigate the mediating mechanisms between harsh parenting and adolescent anxiety symptoms using a multiple mediation model and to further compare specific roles of harsh parenting and distinguish between the living arrangements.

Methods
A total of 3505 adolescents completed this survey, and 3295 adolescents (54.7% girls, Mage = 14.97 years) were included in the study. Participants completed self-assessments measuring harsh parenting, self-efficacy, school connectedness, Internet addiction, sleep problems, and anxiety. They were categorized into three groups based on living arrangements: living with both parents, only with the mother, or only with the father.

Results
Correlational analyses revealed that both maternal and paternal harsh parenting were associated with increased anxiety symptoms. Structural equation modeling (SEM) mediation analyses and multigroup analyses showed that the independent mediating effects of school connectedness, Internet addiction, and sleep problems, as well as the sequential mediating pathways involving self-efficacy → school connectedness, self-efficacy → Internet addiction, and self-efficacy → sleep problems, vary across the adolescents’ living arrangements in the association between maternal and paternal harsh parenting and adolescent anxiety symptoms.

Conclusions
This study elucidated the mechanisms linking harsh parenting to adolescent anxiety symptoms and validated the effects of different parental roles and living arrangements. The findings provide important insights for developing targeted interventions to address anxiety symptoms in adolescents exposed to harsh parenting.
Molecular analysis of BRCA1 and BRCA2 genes in La Rioja (Spain): five new variants
Authors: Salazar Saez Raquel , Zorrilla Miriam , Sánchez Rosa , Cebollero Ana , Manrique Isabel , Martín Alfonso , de Ávila Leticia , Lacalle-Emborujo Alejandra , Martin-Rodriguez Samuel , Bernardo-González Iván , Alonso Martina 
Published: October 2024

Abstract
Background
To study BRCA1/2 gene variants in La Rioja in the northcentral area of Spain.

Methods
We performed a molecular analysis of BRCA1 and BRCA2 in 642 individuals from 427 different families from June 2008 to December 2019.

Results
We identified 71 families with pathogenic variants in these genes, 32 families with BRCA1 variants and 39 families with BRCA2 variants. The pathogenic variants c.959delG in BRCA1 and c.1363_1369delTCAGAGA, c.1397dupA, c.4234_4236delACTinsC and c.8387delC in BRCA2 have not been previously described. The c.81–2 A > T variant in BRCA1, detected in two unrelated families, has not been reported previously in the Spanish population. Two large genomic deletions were found in the BRCA1 gene in exons (Ex) 23–24 and Ex1A-1B-2, and one deletion was found in the BRCA2 gene in Ex2. The pathogenic variant c.5123 C > A in BRCA1 was detected in 8 unrelated families and was the most frequent pathogenic variant in our population. The c.6024dupG mutation in BRCA2 was detected in 6 unrelated families; the c.2808_2011delACAA mutation in BRCA2 was found in 5 different families; the c.211 A > G mutation in BRCA1 was found in three different families; and the c.68_69delAG, c81-2 A > T, c.4038_4039delAA, and c.5266dupC variants in BRCA1 and the c.2457delA, c.2701delC, c.5116_5119delAATA, c.6275delTT, c.7558 C > T and c.7617 + 1G > A variants in BRCA2 were found in two different families.

Conclusions
The spectrum of pathogenic variants in the BRCA1/2 genes in La Rioja is similar to that in other Spanish regions, with some unique characteristics. The pathogenic c.6024dupG variant in the BRCA2 gene was detected in a large number of families and could have a founding effect in the Ebro riverside areas in the regions of La Rioja and Navarra.

Trial registration
Not applicable.
The Staphylococcus aureus-antagonizing human nasal commensal Staphylococcus lugdunensis depends on siderophore piracy
Authors: Rosenstein Ralf , Torres Salazar Benjamin O. , Sauer Claudia , Heilbronner Simon , Krismer Bernhard , Peschel Andreas 
Published: October 2024

Abstract
Background
Bacterial pathogens such as Staphylococcus aureus colonize body surfaces of part of the human population, which represents a critical risk factor for skin disorders and invasive infections. However, such pathogens do not belong to the human core microbiomes. Beneficial commensal bacteria can often prevent the invasion and persistence of such pathogens by using molecular strategies that are only superficially understood. We recently reported that the commensal bacterium Staphylococcus lugdunensis produces the novel antibiotic lugdunin, which eradicates S. aureus from the nasal microbiomes of hospitalized patients. However, it has remained unclear if S. lugdunensis may affect S. aureus carriage in the general population and which external factors might promote S. lugdunensis carriage to enhance its S. aureus-eliminating capacity.

Results
We could cultivate S. lugdunensis from the noses of 6.3% of healthy human volunteers. In addition, S. lugdunensis DNA could be identified in metagenomes of many culture-negative nasal samples indicating that cultivation success depends on a specific bacterial threshold density. Healthy S. lugdunensis carriers had a 5.2-fold lower propensity to be colonized by S. aureus indicating that lugdunin can eliminate S. aureus also in healthy humans. S. lugdunensis-positive microbiomes were dominated by either Staphylococcus epidermidis, Corynebacterium species, or Dolosigranulum pigrum. These and further bacterial commensals, whose abundance was positively associated with S. lugdunensis, promoted S. lugdunensis growth in co-culture. Such mutualistic interactions depended on the production of iron-scavenging siderophores by supportive commensals and on the capacity of S. lugdunensis to import siderophores.

Conclusions
These findings underscore the importance of microbiome homeostasis for eliminating pathogen colonization. Elucidating mechanisms that drive microbiome interactions will become crucial for microbiome-precision editing approaches.
Interdisciplinary perspectives on accessing specialty evidence-based treatment for Medicaid-insured adolescents with eating disorders
Authors: Crest Peyton , Vendlinski Siena S. , Borges Renee , Landsverk John , Accurso Erin C. 
Published: October 2024

Abstract
Background
Family-based treatment (FBT), the leading intervention for adolescents with anorexia nervosa (AN), is severely understudied in outpatient care settings that serve publicly-insured populations. Many individuals with public insurance are lower-income, racially and ethnically diverse, and experience barriers to accessing evidence-based interventions for eating disorders (EDs).

Methods
Semi-structured interviews were conducted with ten interdisciplinary providers who provide specialty care to youth with EDs in an inpatient and/or outpatient medical setting. Interview questions were focused on the interdisciplinary providers’ experiences of caring for individuals with EDs, with a focus on differences in care for those with private insurance compared to public insurance. The interviews took place two years after training in FBT was delivered to mental health providers in San Francisco County, which created opportunities to explore provider perspectives on collaborating with newly-trained mental health providers in the community implementing FBT with publicly-insured youth.

Results
Content analysis converged on three themes: the critical importance of supporting mental health treatment within the context of medical care, complex challenges when helping patients and their families navigate publicly-funded health care systems, and the overall positive impact of the FBT rollout in San Francisco County. Participants emphasized greater confidence in patient outcomes when collaborating with FBT providers and noted discord when working with providers not trained in EDs or FBT. Referral systems, weight-based stigma, and a lack of appropriate services were highlighted as significant barriers to care. To facilitate treatment engagement in publicly-insured populations, participants stressed the importance of clinicians providing psychoeducation and providing services with a high degree of cultural competence. Participants expressed that patients’ ability to access FBT and providers’ ability to collaborate on cases markedly improved following the county training, increasing their sense of efficacy in delivering adequate patient care.

Conclusions
The discussed themes highlight the importance of access to FBT for individuals in underserved communities, which can significantly reduce both provider and patient burden. Despite various barriers to utilizing FBT in publicly-funded settings, clinicians stressed that cultural adaptations increase the implementation of and facilitate family engagement in FBT, which is consistent with previous literature examining evidence-based intervention implementation science.
An algorithm based on multi-branch feature cross fusion for archaeological illustration of murals
Authors: Zeng Xiaolin , Cheng Lei , Li Shanna , Liu Xueping 
Published: October 2024

Abstract
Archaeological illustration is a graphic recording technique that delineates the shape, structure, and ornamentation of cultural artifacts using lines, serving as vital material in archaeological work and scholarly research. Aiming at the problems of low line accuracy in the results of current mainstream image generation algorithms and interference caused by severe mural damage, this paper proposes a mural archaeological illustration generation algorithm based on multi-branch feature cross fusion (U2FGAN). The algorithm optimizes skip connections in U2Net through a channel attention mechanism, constructing a multi-branch generator consisting of a line extractor and an edge detector, which separately identify line features and edge information in artifact images before fusing them to generate accurate, high-resolution illustrations. Additionally, a multi-scale conditional discriminator is incorporated to guide the generator in outputting high-quality illustrations with clear details and intact structures. Experiments conducted on the Dunhuang mural illustration datasets demonstrate that compared to mainstream counterparts, U2FGAN reduced the Mean Absolute Error (MAE) by 10.8% to 26.2%, while also showing substantial improvements in Precision (by 9.8% to 32.3%), Fβ-Score (by 5.1% to 32%), and PSNR (by 0.4 to 2.2 dB). The experimental results show that the proposed method outperforms other mainstream algorithms in archaeological illustration generation.
Cross-institutional evaluation of deep learning and radiomics models in predicting microvascular invasion in hepatocellular carcinoma: validity, robustness, and ultrasound modality efficacy comparison
Authors: Zhang Weibin , Guo Qihui , Zhu Yuli , Wang Meng , Zhang Tong , Cheng Guangwen , Zhang Qi , Ding Hong 
Published: October 2024

Abstract
Purpose
To conduct a head-to-head comparison between deep learning (DL) and radiomics models across institutions for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC) and to investigate the model robustness and generalizability through rigorous internal and external validation.

Methods
This retrospective study included 2304 preoperative images of 576 HCC lesions from two centers, with MVI status determined by postoperative histopathology. We developed DL and radiomics models for predicting the presence of MVI using B-mode ultrasound, contrast-enhanced ultrasound (CEUS) at the arterial, portal, and delayed phases, and a combined modality (B + CEUS). For radiomics, we constructed models with enlarged vs. original regions of interest (ROIs). A cross-validation approach was performed by training models on one center’s dataset and validating the other, and vice versa. This allowed assessment of the validity of different ultrasound modalities and the cross-center robustness of the models. The optimal model combined with alpha-fetoprotein (AFP) was also validated. The head-to-head comparison was based on the area under the receiver operating characteristic curve (AUC).

Results
Thirteen DL models and 25 radiomics models using different ultrasound modalities were constructed and compared. B + CEUS was the optimal modality for both DL and radiomics models. The DL model achieved AUCs of 0.802–0.818 internally and 0.667–0.688 externally across the two centers, whereas radiomics achieved AUCs of 0.749–0.869 internally and 0.646–0.697 externally. The radiomics models showed overall improvement with enlarged ROIs (P < 0.05 for both CEUS and B + CEUS modalities). The DL models showed good cross-institutional robustness (P > 0.05 for all modalities, 1.6–2.1% differences in AUC for the optimal modality), whereas the radiomics models had relatively limited robustness across the two centers (12% drop-off in AUC for the optimal modality). Adding AFP improved the DL models (P < 0.05 externally) and well maintained the robustness, but did not benefit the radiomics model (P > 0.05).

Conclusion
Cross-institutional validation indicated that DL demonstrated better robustness than radiomics for preoperative MVI prediction in patients with HCC, representing a promising solution to non-standardized ultrasound examination procedures.
Associations between symptom-based long COVID clusters and long-term quality of life, work and daily activities among individuals testing positive for SARS-CoV-2 at a national retail pharmacy
Authors: Di Fusco Manuela , Cappelleri Joseph C. , Yehoshua Alon , Craig Kelly J. Thomas , Alvarez Mary B. , Allen Kristen E. , Porter Thomas M. , Lopez Santiago M.C. , Puzniak Laura , Sun Xiaowu 
Published: October 2024

Abstract
Background
Evidence on long COVID symptom clustering patterns among patients with COVID-19 is limited. We summarized long COVID symptoms in clusters defined by number of symptoms co-occurring together, and we assessed Health-Related Quality of Life (HQRoL), Work Productivity and Activity Impairment (WPAI) outcomes across these clusters over time. We assessed associations between the clusters and BNT162b2 vaccination status.

Methods
A prospective longitudinal patient-reported outcomes (PRO) study recruited laboratory-confirmed symptomatic COVID-19 patients seeking testing from a national retail pharmacy. Long COVID-19 symptoms were self-reported by participants at 4-week, 3-month and 6-month surveys. Patient classes identified via latent class analysis (LCA) with long COVID-19 symptoms were simplified into clusters based on number of symptoms. HRQoL and WPAI outcomes were collected using EQ-ED-5L and WPAI: GH questionnaires. Mixed models for repeated measures analyses were conducted to examine associations between exposure groups and outcomes.

Results
The study included 328 participants that were segmented into three groups of long COVID-19 symptoms based on LCA and then simplified by the number of symptoms (Cluster 1 low, <2; Cluster 2 moderate, 2–6; and Cluster 3 high, >6 symptoms). The number of long COVID-19 symptoms was negatively associated with HRQoL and WPAI, whereby participants with high symptom burden (>6 symptoms) had the lowest HRQoL and WPAI scores assessed by absenteeism, presenteeism, work productivity loss, activity impairment, and hours worked metrics. Compared with those unvaccinated and not up-to-date with COVID-19 vaccination, subjects boosted with BNT162b2 consistently reported less symptom burden during the follow-up, regardless of their symptom-based cluster.

Conclusion
Three distinct patient clusters based on frequency of long COVID symptoms experienced different HRQoL and WPAI outcomes over 6 months. The cluster with more concomitant symptoms experienced greater burden than the others. Participants up-to-date with BNT162b2 reported lower symptom burden across all clusters and timeframes.

Clinical trial registration
Clinicaltrials.gov NCT05160636.
Comparative efficacy of Biogents Sentinel and CDC traps for Aedes and Culex mosquito surveillance in India
Authors: Reegan Appadurai Daniel , Gandhi Munusamy Rajiv , Balachandar Manickam , Farajollahi Ary , Kesavaraju Banugopan , Ignacimuthu Savarimuthu 
Published: October 2024

Abstract
Background
Mosquitoes (Diptera: Culicidae) are important arthropod vectors that are responsible for transmitting numerous pathogens of major diseases. Adult mosquito traps help in effective surveillance. In this study, we compared the efficacy of the Biogents® Sentinel (BGS) traps and CO2-baited CDC traps for adult mosquito collection within four sites in India.

Results
We found that BGS traps collected significantly more Culex quinquefasciatus and Aedes aegypti mosquitoes (85.8% of the total catch) than CDC traps (14.9% of the total catch). We also conducted a follow-up experiment to study the effect of adding CO2 as bait along with the BG lure to determine if it increases the number of mosquitoes collected. The results showed that BGS traps with BG lure + CO2 collected significantly more mosquitoes (69.5% of the total catch) than BGS traps with BG lure only (30.5% of the total catch). Although BGS traps were developed for surveillance of Ae. albopictus (Skuse) and Ae. aegypti (L.), the traps collected more Cx. quinquefasciatus (Say.) than any other mosquito species.

Conclusion
BGS trap is an efficient surveillance tool, and it can be used as part of an integrated mosquito management program by public health officials in order to combat mosquito-borne diseases.
Sexual dimorphism and the impact of aging on ball rolling-associated locomotor behavior in Drosophila
Authors: Soyam Gupta , Kannan Nisha N. 
Published: October 2024

ABSTRACT
Insects exhibit a remarkable ability to interact with inanimate objects to facilitate essential behaviors such as foraging, reproduction, shelter building, and defense. In this study, we assessed whether Drosophila interacted with inanimate objects when they were suspended on their wings and provided with a thermocol ball (foam ball). Drosophila indeed exhibited ball rolling behavior. We further examined the sexual dimorphism in this ball rolling-associated locomotor behavior. We carried out a ball rolling assay using 3-day-old male and female w1118 flies and measured the duration for which the flies could roll the ball without dropping it within a 10 min period. The ball was returned to the flies whenever they dropped it, and we calculated the number of times the ball was dropped within the 10 min duration. Females exhibited a longer ball holding duration than males. We also observed a decrease in ball holding duration and an increase in the number of times the ball was dropped by 15-day-old male and female flies than their younger counterparts. These results suggest sexual dimorphism and age-dependent alterations in Drosophila ball rolling-associated locomotor behavior.
Tytuł Guwerner – preceptor – nauczyciel. Szkice z historii edukacji w Polsce i Europie Zachodniej (XVII–XIX w.)
Authors: Jakuboszczak Agnieszka , Kucharski Adam , Wieczorek Agnieszka 
Published: October 2024

Collective work Guwerner – preceptor – nauczyciel. Szkice z historii edukacji w Polsce i Europie Zachodniej (XVII–XIX w.) [Governor – preceptor – teacher. Sketches on the history of education in Poland and Western Europe (17th–19th centuries)] was prepared by a wide circle of historians of culture and education. Among the authors are researchers from various research centers in Poland (Poznań, Toruń, Gdańsk, Lublin, Wrocław, Tarnobrzeg) and France (Bordeaux).	The publication consists of fifteen articles presenting the role of teachers over the centuries – from the 17th century to the beginning of the 19th century. Diversified research on education and upbringing, both at home and at school, was presented from Polish and Western European perspectives. Research on the functions of professors and mistresses in institutions run by religious orders, where children from noble and magnate families often went, was also included. There is also a look at education outside Poland during the Grand Tour around Europe. The last part of the volume is devoted to the selected case of a teacher from France, whose diaries are a testimony to the cosmopolitan nature of education and the importance of the role of preceptors for the cultural changes at the turn of the 18th and 19th centuries.
Salomon Igel – zapomniany uczeń Kazimierza Twardowskiego
Authors: Konstańczak Stefan 
Published: October 2024

Streszczenie
Salomon Igel (1889-1942) był jednym z kilku wypromowanych przez Kazimierza Twardowskiego doktorów psychologii, Zajmował się teoretycznymi podstawami psychologii wywodząc je wprost z filozofii. Stał na stanowisku psychologicznego funkcjonalizmu twierdząc, że zjawiska psychiczne są postrzegane zmysłowo. Za jedyny przedmiot psychologii uważał świadomość. Konsekwentne rozwijanie tego założenia doprowadziło go do próby sformułowania oryginalnej koncepcji filozofii elementów witalnych, która łączyła w sobie odkrycia epistemologii, psychologii oraz fizjologii. W jego dorobku znajdują się również prace z dydaktyki filozofii i psychologii. Zginął śmiercią samobójczą podczas wojny na terenie lwowskiego getta a wraz z nim przepadł cały jego dorobek naukowy i przygotowywane do publikacji wyniki jego najnowszych badań.
Słowa kluczowe: Salomon Igel, Kazimierz Twardowski, psychologia, filozofia, Uniwersytet Jana Kazimierza we Lwowie, Polskie Towarzystwo Filozoficzne
George Berkeley jako neoplatonik? – Wspólne podstawy wczesnej i późnej filozofii Berkeleya
Authors: Płoski Jakub 
Published: October 2024

Późny okres filozofii Berkeleya, związany z publikacją Siris, niekiedy interpretuje się jako zerwanie z tezami okresu wczesnego – tzn. okresu twórczości obejmującego czas do opublikowania Trzech dialogów między Hylasem a Filonousem. W literaturze przedmiotu pojawiają się jednak wzmianki na temat komplementarności pism Berkeleya, pochodzących z różnych lat. Niniejszy artykuł stanowi próbę spojrzenia na system filozoficzny Berkeleya z obu okresów twórczości pod kątem jego podstawowych założeń metafizycznych. Użyty do tego zadania neoplatoński klucz interpretacyjny pozwala w odmienny sposób spojrzeć na niektóre jego elementy, np. zwrócić uwagę na gradualizm metafizyczny jako rdzeń systemu irlandzkiego filozofa. W tej optyce Berkeley staje się przede wszystkim zaangażowanym religijnie metafizykiem, dla którego namysł epistemologiczny stanowi jedynie dopełnienie filozoficznego projektu. Odwołania Berkeleya w Siris do tradycji neoplatońskiej, w myśl przeprowadzanej w artykule interpretacji, nie pełnią jedynie funkcji perswazyjnej (co postulują niektórzy komentatorzy), a wyrażają autentyczny sens filozofii Dobrego Biskupa. Przeciwstawienie wczesnego systemu Berkeleya (empiryzmu) oraz późnego (neoplatonizmu) okazuje się w tej interpretacji bezzasadne, ponieważ twierdzenia teoriopoznawcze uzasadnione są pewną wizją rzeczywistości, związaną z chrześcijańskim neoplatonizmem. Subiektywistyczne ujęcie czasu i przestrzeni nie jawi się wówczas jedynie jako postulat epistemologiczny, wypracowany na gruncie dyskusji z XVII-wieczną filozofią, a twierdzenie metafizyczne, centralne dla systemu myśliciela z Kilkenny.
Słowa kluczowe: George Berkeley, neoplatonizm, idealizm, gradualizm metafizyczny, czas, przestrzeń