bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of using a video diary methodology with older African Americans living alone
Authors: Owens Otis L , Beer Jenay M , Revels Asa , Levkoff Sue 
Published: September 2017

Objectives The goal of this research was to determine whether video diary, a qualitative, self-recorded, video-ethnographic method, is feasible for use among older African Americans (AAs) who live alone. The research, which stems from a larger study on aging in place, focuses specifically on the pros and cons of the video diary and provides recommendations for improving the methodology. Methods Twelve participants were engaged in a 90-minute training on how to record videos using tablet computers, seven days of recording video diaries, and one in-person interview. Results While all participants reported being comfortable with using tablet computers to record video diaries, many participants expressed the need for additional training and assistance. In addition, video diaries recorded by participants commonly exhibited issues (e.g. framing, gaze, and audibility) that compromised video quality. Discussion Video diary may be an effective method for collecting information from older African Americans. However, some suggestions for improving this methodology are providing in-depth video diary and additional camera training, establishing multiple points of contact for technical support, and providing male participants with additional practice.
Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy
Authors: Luckey Stephen W , Haines Chris D , Konhilas John P , Luczak Elizabeth D , Messmer-Kratzsch Antke , Leinwand Leslie A 
Published: September 2017

A number of signaling pathways underlying pathological cardiac hypertrophy have been identified. However, few studies have probed the functional significance of these signaling pathways in the context of exercise or physiological pathways. Exercise studies were performed on females from six different genetic mouse models that have been shown to exhibit alterations in pathological cardiac adaptation and hypertrophy. These include mice expressing constitutively active glycogen synthase kinase-3β (GSK-3βS9A), an inhibitor of CaMK II (AC3-I), both GSK-3βS9A and AC3-I (GSK-3βS9A/AC3-I), constitutively active Akt (myrAkt), mice deficient in MAPK/ERK kinase kinase-1 (MEKK1−/−), and mice deficient in cyclin D2 (cyclin D2−/−). Voluntary wheel running performance was similar to NTG littermates for five of the mouse lines. Exercise induced significant cardiac growth in all mouse models except the cyclin D2−/− mice. Cardiac function was not impacted in the cyclin D2−/− mice and studies using a phospho-antibody array identified six proteins with increased phosphorylation (greater than 150%) and nine proteins with decreased phosphorylation (greater than 33% decrease) in the hearts of exercised cyclin D2−/− mice compared to exercised NTG littermate controls. Our results demonstrate that unlike the other hypertrophic signaling molecules tested here, cyclin D2 is an important regulator of both pathologic and physiological hypertrophy. Impact statement This research is relevant as the hypertrophic signaling pathways tested here have only been characterized for their role in pathological hypertrophy, and not in the context of exercise or physiological hypertrophy. By using the same transgenic mouse lines utilized in previous studies, our findings provide a novel and important understanding for the role of these signaling pathways in physiological hypertrophy. We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac growth in all of the transgenic mice except for the mice deficient in cyclin D2. In the cyclin D2 null mice, cardiac function was not impacted even though the hypertrophic response was blunted and a number of signaling pathways are differentially regulated by exercise. These data provide the field with an understanding that cyclin D2 is a key mediator of physiological hypertrophy.
Primary prevention of stroke and cardiovascular disease in the community (PREVENTS): Methodology of a health wellness coaching intervention to reduce stroke and cardiovascular disease risk, a randomized clinical trial
Authors: Mahon Susan , Krishnamurthi Rita , Vandal Alain , Witt Emma , Barker-Collo Suzanne , Parmar Priya , Theadom Alice , Barber Alan , Arroll Bruce , Rush Elaine , Elder Hinemoa , Dyer Jesse , Feigin Valery 
Published: September 2017

Rationale Stroke is a major cause of death and disability worldwide, yet 80% of strokes can be prevented through modifications of risk factors and lifestyle and by medication. While management strategies for primary stroke prevention in high cardiovascular disease risk individuals are well established, they are underutilized and existing practice of primary stroke prevention are inadequate. Behavioral interventions are emerging as highly promising strategies to improve cardiovascular disease risk factor management. Health Wellness Coaching is an innovative, patient-focused and cost-effective, multidimensional psychological intervention designed to motivate participants to adhere to recommended medication and lifestyle changes and has been shown to improve health and enhance well-being. Aims and/or hypothesis To determine the effectiveness of Health Wellness Coaching for primary stroke prevention in an ethnically diverse sample including Māori, Pacific Island, New Zealand European and Asian participants. Design A parallel, prospective, randomized, open-treatment, single-blinded end-point trial. Participants include 320 adults with absolute five-year cardiovascular disease risk ≥ 10%, calculated using the PREDICT web-based clinical tool. Randomization will be to Health Wellness Coaching or usual care groups. Participants randomized to Health Wellness Coaching will receive 15 coaching sessions over nine months. Study outcomes A substantial relative risk reduction of five-year cardiovascular disease risk at nine months post-randomization, which is defined as 10% relative risk reduction among those at moderate five-year cardiovascular disease risk (10–15%) and 25% among those at high risk (>15%). Discussion This clinical trial will determine whether Health Wellness Coaching is an effective intervention for reducing modifiable risk factors, and hence decrease the risk of stroke and cardiovascular disease.
Genetic variations in the TLR3 locus are associated with eosinophilic esophagitis
Authors: Ávila-Castellano Robledo , García-Lozano José-Raúl , Cimbollek Stefan , Lucendo Alfredo J , Bozada Juan-Manuel , Quiralte Joaquín 
Published: September 2017

Background Eosinophilic esophagitis (EoE) is an antigen-driven disease mediated by an abnormal immune Th2 response. Objective The objective of this article is to investigate genes associated with regulating immune responses leading to disease susceptibility. Methods Twenty-seven tag single nucleotide polymorphisms (tSNPs) selected in five candidate genes ( TLR3, TLR4, FOXP3, FLG and TSLP) were genotyped in 218 EoE patients and 376 controls. Skin prick tests were carried out in EoE patients with a panel of 17 aeroallergens and 22 plant- and animal-derived foods. Results Five tSNPs located in the TSLP locus and one tSNP located in the TLR3 locus were significantly associated with EoE. The interactions between TLR3 and TSLP loci were analyzed. TLR3+/TSLP– and TLR3–/TSLP+ individuals showed a significantly reduced susceptibility to EoE compared to TLR3–/TSLP– individuals (OR = 0.66, p = 0.036 and OR = 0.23, p = 0.00014, respectively). Likewise, TLR3+/TSLP+ individuals showed the most decreased susceptibility of developing EoE (OR = 0.16, p = 0.0001). However, the interaction gain attributed to the combination of both genes was negative (IG = –4.52%), which indicated redundancy or independent effect. Additionally, TLR3 locus was found to be associated with aeroallergen and food sensitization in EoE patients (OR = 9.67, pc = 0.025 and OR = 0.53, pc = 0.048, respectively). Conclusion TLR3 constitutes a novel genetic susceptibility locus for developing EoE, and the effects would be independent of TSLP.
Quantitative characterization of optic nerve atrophy in patients with multiple sclerosis
Authors: Harrigan Robert L , Smith Alex K , Lyttle Bailey , Box Bailey , Landman Bennett A , Bagnato Francesca , Pawate Siddharama , Smith Seth A 
Published: September 2017

Background Optic neuritis (ON) is one of the most common presentations of multiple sclerosis (MS). Magnetic resonance imaging (MRI) of the optic nerves is challenging because of retrobulbar motion, orbital fat and susceptibility artifacts from maxillary sinuses; therefore, axonal loss is investigated with the surrogate measure of a single heuristically defined point along the nerve as opposed to volumetric investigation. Objective The objective of this paper is to derive optic nerve volumetrics along the entire nerve length in patients with MS and healthy controls in vivo using high-resolution, clinically viable MRI. Methods An advanced, isotropic T2-weighted turbo spin echo MRI was applied to 29 MS patients with (14 patients ON+) or without (15 patients ON–) history of ON and 42 healthy volunteers. An automated tool was used to estimate and compare whole optic nerve and surrounding cerebrospinal fluid radii along the length of the nerve. Results and conclusion Only ON+ MS patients had a significantly reduced optic nerve radius compared to healthy controls in the central segment of the optic nerve. Using clinically available MRI methods, we show and quantify ON volume loss for the first time in MS patients.
Nonclassical FCGR2C haplotype is associated with protection from red blood cell alloimmunization in sickle cell disease
Authors: Meinderts Sanne M. , Sins Joep W. R. , Fijnvandraat Karin , Nagelkerke Sietse Q. , Geissler Judy , Tanck Michael W. , Bruggeman Christine , Biemond Bart J. , Rijneveld Anita W. , Kerkhoffs Jean-Louis H. , Pakdaman Sadaf , Habibi Anoosha , van Bruggen Robin , Kuijpers Taco W. , Pirenne France , van den Berg Timo K. 
Published: September 2017

Key PointsVariation in the Fcγ receptor gene cluster is associated with protection from RBC alloimmunization in patients with SCD. This association appears to be strongest for alloimmunization to antigens other than the immunogenic Rh or K.
Predicting early transition from sub-syndromal presentations to major mental disorders
Authors: Cross Shane P.M. , Scott Jan , Hickie Ian B. 
Published: September 2017

BackgroundTransition from at-risk state to full syndromal mental disorders is underexplored for unipolar and bipolar disorders compared with psychosis.AimsProspective, trans-diagnostic study of rates and predictors of early transition from sub-threshold to full syndromal mental disorder.MethodOne-year outcome of 243 consenting youth aged 15–25 years with a sub-syndromal presentation of a potentially severe mental disorder. Survival analysis and odds ratio (OR) for predictors of transition identified from baseline clinical and demographic ratings.ResultsAbout 17% (n=36) experienced transition to a major mental disorder. Independent of syndromal diagnosis, transition was significantly more likely in individuals who were NEET (not in education, employment or training), in females and in those with more negative psychological symptoms (e.g. social withdrawal).ConclusionsNEET status and negative symptoms are modifiable predictors of illness trajectory across diagnostic categories and are not specific to transition to psychosis.
Ocorrência de Corythaica passiflorae (Berg) (Hemiptera: Tingidae) em cultivos comerciais de jiló e berinjela no Estado do Tocantins, Brasil
Authors: Ferreira Cleidiane de Andrade , Coelho Luci Boa Nova , Santos Rodrigo Souza 
Published: September 2017

Resumo. Uma alta infestação de Corythaica passiflorae (Berg) (Hemiptera: Tingidae) foi observada em plantas de jiló (Solanum aethiopicum L. - grupo gilo) e berinjela (Solanum melongena L.), em uma área de cultivo comercial no município de Paraíso do Tocantins, estado do Tocantins. Os insetos popularmente conhecidos como percevejos-de-renda foram observados em um alto número populacional, na face inferior das folhas, provocando injúrias e consequente prejuízo econômico, com elevada queda na produção e mortalidade de plantas. Além disso, também foi observada a associação do tingídeo com plantas de ocorrência espontânea, tais como a jurubeba (Solanum paniculatum L.) e o joá (Solanum viarum Dunal), comuns na região e, que podem contribuir para a disseminação dos insetos em outras áreas produtoras de solanáceas. Este trabalho registra a primeira ocorrência de C. passiflorae em plantios comerciais de jiló e berinjela no estado de Tocantins, além do registro de novas plantas hospedeiras desse tingídeo (joá e jurubeba) no Brasil.Occurrence of Corythaica passiflorae (Berg) (Hemiptera: Tingidae) on commercial plantations of gilo and eggplant in Tocantins state, BrazilAbstract. A high infestation of Corythaica passiflorae (Berg) (Hemiptera: Tingidae) was observed in gilo plants (Solanum aethiopicum L. – gilo group) and eggplant (Solanum melongena L.) in a commercial plantation area in the municipality of Paraíso do Tocantins, Tocantins state, Brazil. The insects popularly known as lace bugs were observed in a high population on the underside of the leaves, causing damages and consequent economic loss, with a high drop in plant production and plant mortality. Therefore, the association of the tingid with plants of spontaneous occurrence, such as jurubeba (Solanum paniculatum L.) and tropical soda apple (Solanum viarum Dunal), common in the region, which may contribute to the dissemination of insects in other solanaceous producing areas. This work reports the first occurrence of C. passiflorae in commercial plantations of gilo and eggplant in Tocantins state, besides the registration of new host plants of this tingid (joá and jurubeba) in Brazil.
Lameness — preventative management strategies
Authors: Page Phillipa , Lovatt Fiona 
Published: September 2017

Sheep lameness is a widespread health issue affecting most flocks within the UK. The authors consider that flock levels above 2% are significant in terms of production losses and challenges with control. Concern for sheep welfare, losses in production of the flock and the associated costs of a lameness problem are some of the reasons for a farmer contacting their veterinary surgeon for help and advice. This article focuses on the common infectious causes of sheep lameness: scald, footrot and contagious ovine digital dermatitis (CODD). It seeks to provide the most up to date research surrounding the aetiology of these diseases and treatments. Defining the risk factors for lameness on a farm is an important aspect when developing a preventative management strategy for the control of lameness. These risk factors will be discussed. The 5-Point Plan is an industry wide recognised plan for controlling lameness. How to implement this plan on farm including the use of vaccination and good practice quarantine procedures will be described in this article.
Checklist of Macroalgae in Waisai Coast, Raja Ampat
Authors: Suryandari Retno , Widodo Widodo 
Published: September 2017

Macroalgae are very abundant organisms in Indonesian coastal zone. They comprise 8.6% of the total marine organisms.The aim of the research was to identify macroalgae in Waisai Coast Raja Ampat. The results showed that 38 macroalgae were found in Waisai Coast Raja Ampat but only 29 species of macroalgae can be identified. Macroalgae found in Waisai Coast Raja Ampat are green algae, red algae and brown algae. Green algae found and identified are <em>Caulerpa macra </em>(Weber-van Bosse) Draisma &amp; Prud’homme, <em>Caulerpa racemosa var. macrophysa </em>(Sonder wx Kutzing) W.R.Taylor, <em> Caulerpa sertularoides</em> (S. Gmelin) Howe f. brevipes (J. Agardh Svedilus), <em>Caulerpa cupressoides</em> (Vahl) C. Agardh, <em>Halimeda discoidea</em> Decaisne, <em>Halimeda Opuntia</em> (Linnaeus) J.V. Lamoroux, <em>Halimeda tuna</em> (J. Ellis &amp; Solander) J.V. Lamoroux, <em>Halimeda cylindraceae</em> Decaisne, <em>Halimeda macroloba</em> Decaisne, <em>Avrainvillea erecta</em> (Berkeley) A. Gepp &amp; E.S. Gepp, <em>Codium geppiorum</em> O.C.Schmidt, <em>Boergesenia forbesii</em> (Hardvey) Feldmann, <em>Valonia ventricosa</em> J. Agardh, <em>Dictyosphaeria cavernosa</em> (Forsskål) Børgesen, <em>Chaetomorpha spiralis</em>Okamura, <em>Anadyomene wrightii</em> Harvey ex. J. E. Gray, <em>Neomeris annulata</em> Dickie. Red algae species found and successfully identified are<em>Acanthophora spicifera</em> (M. Vahl) Børgesen, <em>Laurencia papilosa</em> (C. Agardh) Greville, <em>Gracilaria salicornia</em> (C. Agardh) E.Y. Dawson, <em>Amphiora fragilissima</em> (Linnaeus) J.V. Lamoroux, <em>Hypnea pannosa</em> J. Agardh. Brown algae species found and identified are <em>Hormophysa cuneiformis</em> (J.F. Gmelin) P.C. Silva, <em>Sargassum aquifolium</em> (Turner) C. Agardh, <em>Sargassum polycystum</em> C. Agardh, <em>Turbinaria ornata</em> (Turner) J. Agardh, <em>Padina australis</em> Hauck, <em>Canistrocarpus cervicornis </em>(Kutzing) De Paula &amp; De Clerck<em> Hydroclathrus clatratus</em> (C. Agardh ) M. Howe. The only species found in Indonesia is <em>Sargassum aquifolium.</em>
Competitive Search with Ex-post Opportunism
Authors: Gomis-Porqueras Pedro , Julien Benoît , Wang Liang 
Published: September 2017

Abstract:We consider a frictional market where an element of the terms of trade (price or quantity) is posted ex-ante (before the matching process) while the other is determined ex-post. By doing so, sellers can exploit their local monopoly power by adjusting prices or quantities once the local demand is realized. We find that when sellers can adjust quantities ex-post, there exists a unique symmetric equilibrium where an increase in the buyer-seller ratio leads to higher quantities and prices. When buyers instead can choose quantities ex-post, a higher buyer-seller ratio leads to higher prices but lower traded quantities. These equilibrium allocations are generically constrained inefficient in both intensive and extensive margins. When sellers post ex-ante quantities and adjust prices ex-post, a symmetric equilibrium exists where buyers obtain no surplus from trade. This equilibrium allocation is not constrained efficient either. If buyers choose prices ex-post, there is no trade in equilibrium when entry is costly.
Can a language spread from bottom upwards? A study on the spread of standard Chinese in Johor, Malaysia
Authors: Xiaomei Wang 
Published: September 2017

Abstract
Language spread as defined by (Cooper, Robert Leon. 1982. A framework for the study of language spread. In Robert L. Cooper (eds.), Language spread: Studies in diffusion and social change, 5–36. Bloomington: Indiana University Press) became a new research branch after (Fishman, Joshua Aaron. 1989. The spread of English as a new perspective for the study of ‘Language Maintenance and Language Shift.’ In Joshua A. Fishman (eds.), Language and ethnicity in minority sociolinguistic perspective, 32–263. Clevedon: Multilingual Matters) seminal work. In literature, most of the languages in spread are European languages such as English and Spanish. (Fishman, Joshua Aaron. 1989. The spread of English as a new perspective for the study of ‘Language Maintenance and Language Shift.’ In Joshua A. Fishman (eds.), Language and ethnicity in minority sociolinguistic perspective, 32–263. Clevedon: Multilingual Matters) contended that the spread of English was a top-down process. (Garcia, Ofelia.2002. Language spread and its study: Narrowing its spread as a scholarly field. In Robert B. Kaplan (eds.), The oxford handbook of applied linguistics, 352–364. New York: Oxford University Press) also proposed that language spread started first in high societal domains. However, according to our study in Malaysia, standard Chinese undertook a different route in its process of spread. It spreads its use first in high domains such as the education domain and then in low domains such as the family domain. This paper aims to answer the research question whether it is possible for a language to spread from bottom upwards as compared to the well-known top-down spread. The empirical basis of this paper is a language survey conducted by the researcher in the state of Johor, Malaysia. In this study, questionnaires, home interviews and un-intrusive observations were used as the research methods. By comparing the spread process of English and Chinese—both transnational languages due to globalization–this paper will contribute to the theory of language spread and identify the differences between the spread of English and the spread of Chinese.
On the History of Global Chinese and Its Research
Authors: Yanbin Diao 
Published: September 2017

AbstractThe formation and development of Global Chinese as a field of inquiry involves a process, every phase of which requires substantial evidence, regularity and theoretical motivation. In general, Global Chinese has a history and the research on Global Chinese needs to focus on its history. Conceptually, the history of Global Chinese should contain at least four main points. It is a history of the global spread of the Chinese language; it is situated at a higher level than the history of Modern Chinese; it is an integral part of the history of the Chinese language, and it is an extension of the history of Chinese. The study of the history of Global Chinese should include at least four aspects: the continuous migration of the Chinese people; the impact of local social life and language culture on overseas Chinese; the influence of foreign languages, and the interactions between and changes of varieties of in different parts of the world. As for the research methods of the history of Global Chinese history, a multidimensional model is proposed.
华语动词 “相信” 的情态功能及其来源
Authors: 计伟 李 , 梦帆 张 
Published: September 2017

摘 要：
在马来西亚华语、新加坡华语及港式中文中，动词 “相信” 在施事主语省略或言者主语隐身的句法条件下，其后宾语小句之主语可以提升至句首，从而具有强烈的情态功能，这一变化应是汉语内部结构因素和语言接触外部因素合力作用的结果。
Strupczewski Method for Parametric Design Hydrographs in Ungauged Cross-Sections
Authors: Gądek Wiesław , Baziak Beata , Tokarczyk Tamara 
Published: September 2017

Abstract
Nonparametric hydrographs, constructed by the method suggested by Archer, are usually used for developing parametric design hydrographs. Flow changes in time are described by the UPO ERR Gamma complex function, which denotes a Gamma curve reformulated to have a Unit Peak at the Origin (abbreviated to UPO), supplemented by the Exponential Replacement Recession (ERR) curve. It may be observed, that this solution does not work in some areas of the upper Vistula and middle Odra catchments when the times of the rising limb of a hydrograph are higher than the times of the falling limb, i.e. when the skewness coefficient approximates 0.5 or higher values. Better results can be achieved with the function suggested by Strupczewski in 1964. It is a solution which uses two parameters of the flood hydrograph. The objective of the present paper is to assess the Strupczewski method by comparing it with a complex UPO ERR Gamma function for gauged cross-sections in the upper Vistula and middle Odra catchments. The assessment was carried out for 30 gauged cross-sections (15 in each river catchment). The parameters were optimized for width-hydrograph descriptors W75 and W50, designed by the Archer method, and for the skewness coefficient s. Optimization using only two width-hydrograph descriptors aims to test how the Strupczewski method works for cross-sections for which the values of width-hydrograph descriptors W75 and W50 are known. The assessment of both methods was carried out with reference to a nonparametric hydrograph constructed by the Archer method. The results of these assessments suggest that the Strupczewski method may be used not only for gauged cross-sections, but also for ungauged ones.