bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactivity to unpredictable threat as a treatment target for fear-based anxiety disorders
Authors: Gorka S. M. , Lieberman L. , Klumpp H. , Kinney K. L. , Kennedy A. E. , Ajilore O. , Francis J. , Duffecy J. , Craske M. G. , Nathan J. , Langenecker S. , Shankman S. A. , Phan K. L. 
Published: April 2017

BackgroundHeightened reactivity to unpredictable threat (U-threat) is a core individual difference factor underlying fear-based psychopathology. Little is known, however, about whether reactivity to U-threat is a stable marker of fear-based psychopathology or if it is malleable to treatment. The aim of the current study was to address this question by examining differences in reactivity to U-threat within patients before and after 12-weeks of selective serotonin reuptake inhibitors (SSRIs) or cognitive-behavioral therapy (CBT).MethodsParticipants included patients with principal fear (n= 22) and distress/misery disorders (n= 29), and a group of healthy controls (n= 21) assessed 12-weeks apart. A well-validated threat-of-shock task was used to probe reactivity to predictable (P-) and U-threat and startle eyeblink magnitude was recorded as an index of defensive responding.ResultsAcross both assessments, individuals with fear-based disorders displayed greater startle magnitude to U-threat relative to healthy controls and distress/misery patients (who did not differ). From pre- to post-treatment, startle magnitude during U-threat decreased only within the fear patients who received CBT. Moreover, within fear patients, the magnitude of decline in startle to U-threat correlated with the magnitude of decline in fear symptoms. For the healthy controls, startle to U-threat across the two time points was highly reliable and stable.ConclusionsTogether, these results indicate that startle to U-threat characterizes fear disorder patients and is malleable to treatment with CBT but not SSRIs within fear patients. Startle to U-threat may therefore reflect an objective, psychophysiological indicator of fear disorder status and CBT treatment response.
On the religious worth of bodily liturgical action
Authors: CUNEO TERENCE 
Published: April 2017

AbstractA striking feature of the Eastern Orthodox liturgies is how much movement and touching occurs during their performance. For example, when participants in these liturgies enter into a church building, they do not simply look at the icons; they typically venerate them by kissing them. Call events such as these scripted movement-touching sequences. The question I pursue in this article is why movement-touching sequences play such prominent roles in the performance of the Eastern liturgies. The answer I offer is that the performance of these actions has religious worth. I then consider two models that attempt to explain why the performance of scripted movement-touching sequences has religious worth. After exploring and rejecting what I call the instrumentalist model, I develop what I term the authorization-appropriation model of the composition of the church's liturgies. According to this model, the religious worth of scripted bodily liturgical action lies (in part) in the fact that God has both authorized the composition of and appropriated the liturgical scripts that prescribe the performance of such actions.
From Democratic Consultation to User-employment: Shifting Institutional Embedding of Citizen Involvement in Health and Social Care
Authors: ALM ANDREASSEN TONE 
Published: April 2017

AbstractPolicies of citizen involvement in health and social care have given rise to a variety of organisational forms, which address citizens in different capacities and differ in their demands as to the representativeness, performance and competence of those involved. Apparently, the policies draw on different institutional logics. Based on extant studies, partly the author's own research from Norway, this article sheds light on three purposefully selected cases of citizen involvement. Two models of democratic consultation encompass a dominant model of involvement in Norway (advisory bodies of service users) and a model more prevalent in UK (panels of the general public). These are both embedded within a logic of democracy. A third emergent model of involvement is one in which citizens with experience as service users are engaged as workers in service providing organisations. This model resembles an idea of co-production. However, when involvement is organised as user-employment and paid work, the model rather seems rooted within the logic of the market – the labour market of service workers. The rise of this model suggests a shift in institutional embedding of citizen involvement. The analysis of these models provides a framework of distinguishing dimensions between different models of involvement.
Action in interaction is conduct under a description
Authors: Sidnell Jack 
Published: April 2017

AbstractRequests, offers, invitations, complaints, and greetings are some of the many action types routinely invoked in the description and analysis of interaction. But what is the ontological status of, for instance, a request? In what follows I propose that action is conduct under a description. Thus, for the most part, interaction is organized independently of any action description or categorization of conduct into discrete action types. Instead, participants in interaction draw on the details of the situation in which they find themselves in order to produce conduct that others will recognize and to which they are able to respond in fitted ways. ‘Action’ still plays a key role in the organization of interaction, however, because accountability attaches not to raw conduct but only to conduct under some particular, action-formulating description. (Action, interaction, description, conversation analysis, Anscombe)*
CARDIOVASCULAR SCREENING OF YOUNG ATHLETES: A REVIEW OF ECONOMIC EVALUATIONS
Authors: Gerkens Sophie , Van Brabandt Hans , Desomer Anja , Leonard Christian , Neyt Mattias 
Published: April 2017

Objectives: Some experts have promoted preparticipative cardiovascular screening programs for young athletes and have claimed that such programs were cost-effective without performing a critical analysis of studies supporting this statement. In this systematic review, a critical assessment of economic evaluations on these programs is performed to determine if they really provide value for money.Methods: A systematic review of economic evaluations was performed on December 24, 2014. Web sites of health technology assessment agencies, the Cochrane database of systematic review, the National Health Service Economic Evaluation Database of the Cochrane Library, EMBASE, Medline, Psychinfo, and EconLit were searched to retrieve (reviews of) economic evaluations. No language or time restrictions were imposed and predefined selection criteria were used. Selected studies were critically assessed applying a structured data extraction sheet.Results: Five relevant economic evaluations were critically assessed. Results of these studies were mixed. However, those in favor of screening made (methodological) incorrect choices, of which the most important one was not taking into account a no-screening alternative as comparator. Compared with no screening, other strategies (history and physical examination or history and physical examination plus electrocardiogram) were not considered cost-effective.Conclusions: Results of primary economic evaluations should not be blindly copied without critical assessment. Economic evaluations in this field lack the support of robust evidence. Negative consequences of screening (false positive findings, overtreatment) should also be taken into account and may cause more harm than good. A mass screening of young athletes for cardiovascular diseases does not provide value for money and should be discouraged.
Using camera traps to examine distribution and occupancy trends of ground-dwelling rainforest birds in north-eastern Madagascar
Authors: MURPHY ASIA J. , FARRIS ZACH J. , KARPANTY SARAH , KELLY MARCELLA J. , MILES KATHLEEN A. , RATELOLAHY FÉLIX , RAHARINIAINA RAYMOND P. , GOLDEN CHRISTOPHER D. 
Published: April 2017

SummaryCamera trap surveys are a non-invasive way to monitor wildlife populations. Although most often used to study medium- and large-sized mammals, camera traps also detect non-target species. These detections provide useful ecological information on little-known species, but such data usually remain unanalysed. We used detections from camera-trapping surveys of native carnivores and small mammals to examine distribution patterns and occupancy trends of little-known ground-dwelling rainforest birds at seven sites across the Masoala-Makira protected area complex in north-eastern Madagascar. We obtained 4,083 detections of 28 bird species over 18,056 trap nights from 200 to 2013. We estimated occupancy across the Masoala-Makira protected area complex (hereafter, landscape occupancy) and annual trends in occupancy at three resurveyed sites for five commonly observed species. Landscape occupancy across Masoala-Makira ranged from 0.75 (SE 0.09; Madagascar Magpie-robinCopsychus albospecularis) to 0.25 (SE 0.06; Scaly Ground-rollerGeobiastes squamiger). Ground-dwelling forest bird occupancy was similar at forest sites that ranged from intact to fully degraded; however, three species were detected less often at sites with high feral cat trap success. Nearly half of all focal species showed declines in annual occupancy probability at one resurveyed site (S02) from 2008 to 2013. The declines in ground-dwelling bird occupancy could have community-wide consequences as birds provide ecosystem services such as seed dispersal and pest regulation. We suggest immediate conservation measures—such as feral cat removal—be implemented to protect ground-dwelling forest birds and other threatened taxa across this landscape.
NEGLIGENCE AND ACCOMMODATION
Authors: Dorfman Avihay 
Published: April 2017

ABSTRACTWhereas the Restatement of Torts and leading economic and justice-based approaches to explaining the standard of reasonable care advocate symmetric measurement of reasonable care across the defendant/plaintiff distinction, this article demonstrates that, in fact, the law applies this standard asymmetrically. Defendants are expected to discharge an objectively fixed amount of care, whereas plaintiffs are generally assessed using a subjective measurement of reasonable care. Normatively, I argue that an asymmetric assessment of care, because it combines an unfavorable assessment of defendant's negligence with a favorable assessment of plaintiff's negligence, means that the victim gets to fix the terms of the interaction. This argument resonates with the powerful egalitarian idea of accommodating, rather than overlooking, relevant differences; different treatment is necessary for the duty of reasonable care to give effect to the qualitative difference between the plaintiff's life and limb and the defendant's autonomy. Asymmetric assessment of due care, I argue, is the doctrinal metric by which the law determines what it is for the plaintiff and the defendant to relate as equals given that difference, or to relate as substantive equals.
Association between Sleep Disordered Breathing and Nighttime Driving Performance in Mild Cognitive Impairment
Authors: Cross Nathan , Terpening Zoe , Duffy Shantel L. , Lewis Simon J.G. , Grunstein Ron , Wong Keith , Naismith Sharon L. 
Published: April 2017

AbstractObjectives:The effect of sleep disordered breathing (SDB) on driving performance in older adults has not been extensively investigated, especially in those with mild cognitive impairment (MCI). The aim of this study was to examine the relationship between severity measures of SDB and a simulated driving task in older adults with and without MCI.Methods:Nineteen older adults (age ≥50) meeting criteria for MCI and 23 age-matched cognitively intact controls underwent neuropsychological assessment and a driving simulator task in the evening before a diagnostic sleep study.Results:There were no differences in driving simulator performance or SDB severity between the two groups. In patients with MCI, a higher oxygen desaturation index (ODI) was associated with an increased number of crashes on the simulator task, as well as other driving parameters such as steering and speed deviation. Poorer driving performance was also associated with poorer executive functioning (set-shifting) but the relationship between ODI and crashes was independent of executive ability.Conclusions:While driving ability did not differ between older adults with and without MCI, oxygen saturation dips in MCI were related to worse driving performance. These results suggest that decreased brain integrity may render those with SDB particularly vulnerable to driving accidents. In older adults, both cognition and SDB need to be considered concurrently in relation to driving ability. (JINS, 2017,23, 502–510)
Local Structural Damage Evaluation of a C/C–SiC Ceramic Matrix Composite
Authors: Arhatari Benedicta D. , Zonneveldt Matthew , Thornton John , Abbey Brian 
Published: April 2017

AbstractCeramic matrix composites (CMCs) are structural materials, which have useful properties that combine high strength at high temperatures with moderate toughness. Carbon fibers within a matrix of carbon and silicon carbide, called C/C–SiC, are a particular class of CMC noted for their high oxidation resistance. Here we use a combination of four-point bending and X-ray radiography, to study the mechanical failure of C/C-SiC CMCs. Correlating X-ray radiographic and load/displacement curve data reveals that the fiber bundles act to slow down crack propagation during four-point bending tests. We attribute this to the fact that strain energy is expended in breaking these fibers and in pulling fiber bundles out of the surrounding matrix material. In addition, we find that the local distribution and concentration of SiC plays an important role in reducing the toughness of the material.
Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer’s disease
Authors: Venkatesan Ramu , Park Yong Un , Ji Eunhee , Yeo Eui-Ju , Kim Sun Yeou 
Published: April 2017

AbstractMalathion is an organophosphate with severe neurotoxic effects. Upon acute exposure, malathion initially enhances cholinergic activity by inhibition of acetylcholinesterase, which is its major pathological mechanism. Malathion also induces non-cholinergic neuronal cell death in neurodegenerative conditions; the associated molecular mechanism is not well-characterized. To investigate the molecular mechanism of malathion-induced cell death, N2a mouse neuroblastoma cells were exposed to malathion and cell death-related parameters were examined. Malathion reduced cell viability mainly by apoptosis through mitochondrial dysfunction in N2a cells, as judged by an increase in the level of the pro-apoptotic protein Bax and decrease in the levels of the anti-apoptotic proteins p-Akt and Bcl2, resulting in cytochrome c release and caspase-dependent DNA fragmentation and condensation. Malathion treatment also induced autophagy and lysosomal membrane permeabilization (LMP) in N2a cells. LMP caused a lessening of autophagic flux via inhibition of lysosomal fusion with the autophagosome. LMP-induced cathepsin B release and its proteolytic effect may intensify apoptotic insults. Moreover, malathion-exposed N2a cells showed a marked reduction in the levels of the neuronal marker proteins vascular endothelial growth factor and heart fatty acid binding protein 3, along with diminished neuritogenesis in N2a cells and nerve growth factor secretion in C6 glioma cells. Our data suggest that the non-cholinergic effect of malathion may be mediated by apoptotic cell death via LMP induction in N2a cells. Malathion-treated N2a cells can be utilized as an in vitro model system to screen natural and new chemical drug candidates for neurodegenerative diseases such as Alzheimer’s disease.
Hydrophilic surface modification of PDMS for droplet microfluidics using a simple, quick, and robust method via PVA deposition
Authors: Trantidou Tatiana , Elani Yuval , Parsons Edward , Ces Oscar 
Published: April 2017

AbstractPolydimethylsiloxane (PDMS) is a dominant material in the fabrication of microfluidic devices to generate water-in-oil droplets, particularly lipid-stabilized droplets, because of its highly hydrophobic nature. However, its key property of hydrophobicity has hindered its use in the microfluidic generation of oil-in-water droplets, which requires channels to have hydrophilic surface properties. In this article, we developed, optimized, and characterized a method to produce PDMS with a hydrophilic surface via the deposition of polyvinyl alcohol following plasma treatment and demonstrated its suitability for droplet generation. The proposed method is simple, quick, effective, and low cost and is versatile with respect to surfactants, with droplets being successfully generated using both anionic surfactants and more biologically relevant phospholipids. This method also allows the device to be selectively patterned with both hydrophilic and hydrophobic regions, leading to the generation of double emulsions and inverted double emulsions.
Resonant pitch and roll silicon gyroscopes with sub-micron-gap slanted electrodes: Breaking the barrier toward high-performance monolithic inertial measurement units
Authors: Wen Haoran , Daruwalla Anosh , Ayazi Farrokh 
Published: April 2017

AbstractThis paper presents the design, fabrication, and characterization of a novel high quality factor (Q) resonant pitch/roll gyroscope implemented in a 40 μm (100) silicon-on-insulator (SOI) substrate without using the deep reactive-ion etching (DRIE) process. The featured silicon gyroscope has a mode-matched operating frequency of 200 kHz and is the first out-of-plane pitch/roll gyroscope with electrostatic quadrature tuning capability to fully compensate for fabrication non-idealities and variation in SOI thickness. The quadrature tuning is enabled by slanted electrodes with sub-micron capacitive gaps along the (111) plane created by an anisotropic wet etching. The quadrature cancellation enables a 20-fold improvement in the scale factor for a typical fabricated device. Noise measurement of quadrature-cancelled mode-matched devices shows an angle random walk (ARW) of 0.63° √h−1 and a bias instability of 37.7° h−1, partially limited by the noise of the interface electronics. The elimination of silicon DRIE in the anisotropically wet-etched gyroscope improves the gyroscope robustness against the process variation and reduces the fabrication costs. The use of a slanted electrode for quadrature tuning demonstrates an effective path to reach high-performance in future pitch and roll gyroscope designs for the implementation of single-chip high-precision inertial measurement units (IMUs).
Band structure engineered layered metals for low-loss plasmonics
Authors: Gjerding Morten N. , Pandey Mohnish , Thygesen Kristian S. 
Published: April 2017

AbstractPlasmonics currently faces the problem of seemingly inevitable optical losses occurring in the metallic components that challenges the implementation of essentially any application. In this work, we show that Ohmic losses are reduced in certain layered metals, such as the transition metal dichalcogenide TaS2, due to an extraordinarily small density of states for scattering in the near-IR originating from their special electronic band structure. On the basis of this observation, we propose a new class of band structure engineered van der Waals layered metals composed of hexagonal transition metal chalcogenide-halide layers with greatly suppressed intrinsic losses. Using first-principles calculations, we show that the suppression of optical losses lead to improved performance for thin-film waveguiding and transformation optics.
Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish
Authors: Wang Lei , Ma Xiao , Xu Xiaolei , Zhang Yuji 
Published: April 2017

AbstractLong intergenic noncoding RNAs (lincRNAs) are increasingly recognized as potential key regulators of heart development and related diseases, but their identities and functions remain elusive. In this study, we sought to identify and characterize the cardiac lincRNA transcriptome in the experimentally accessible zebrafish model by integrating bioinformatics analysis with experimental validation. By conducting genome-wide RNA sequencing profiling of zebrafish embryonic hearts, adult hearts, and adult muscle, we generated a high-confidence set of 813 cardiac lincRNA transcripts, 423 of which are novel. Among these lincRNAs, 564 are expressed in the embryonic heart, and 730 are expressed in the adult heart, including 2 novel lincRNAs, TCONS_00000891 and TCONS_00028686, which exhibit cardiac-enriched expression patterns in adult heart. Using a method similar to a fetal gene program, we identified 51 lincRNAs with differential expression patterns between embryonic and adult hearts, among which TCONS_00009015 responded to doxorubicin-induced cardiac stress. In summary, our genome-wide systematic identification and characterization of cardiac lincRNAs lays the foundation for future studies in this vertebrate model to elucidate crucial roles for cardiac lincRNAs during heart development and cardiac diseases.
Seasonal variations of leaf and canopy properties tracked by ground-based NDVI imagery in a temperate forest
Authors: Yang Hualei , Yang Xi , Heskel Mary , Sun Shucun , Tang Jianwu 
Published: April 2017

AbstractChanges in plant phenology affect the carbon flux of terrestrial forest ecosystems due to the link between the growing season length and vegetation productivity. Digital camera imagery, which can be acquired frequently, has been used to monitor seasonal and annual changes in forest canopy phenology and track critical phenological events. However, quantitative assessment of the structural and biochemical controls of the phenological patterns in camera images has rarely been done. In this study, we used an NDVI (Normalized Difference Vegetation Index) camera to monitor daily variations of vegetation reflectance at visible and near-infrared (NIR) bands with high spatial and temporal resolutions, and found that the infrared camera based NDVI (camera-NDVI) agreed well with the leaf expansion process that was measured by independent manual observations at Harvard Forest, Massachusetts, USA. We also measured the seasonality of canopy structural (leaf area index, LAI) and biochemical properties (leaf chlorophyll and nitrogen content). We found significant linear relationships between camera-NDVI and leaf chlorophyll concentration, and between camera-NDVI and leaf nitrogen content, though weaker relationships between camera-NDVI and LAI. Therefore, we recommend ground-based camera-NDVI as a powerful tool for long-term, near surface observations to monitor canopy development and to estimate leaf chlorophyll, nitrogen status, and LAI.