bluuebunny/crossref_metadata_2025_split huggingface dataset:
How labels shape visuocortical processing in infants
Authors: Boylan Maeve R. , Garner Bailey , Kutlu Ethan , Sanches Braga Figueira Jessica , Barry‐Anwar Ryan , Pestana Zoe , Keil Andreas , Scott Lisa S. 
Published: September 2024

AbstractThe current study examined the extent to which labels shape visuocortical processing during the first year of life during a brief (~6‐min) associative learning task. Images of computer‐generated artificial objects were paired with either individual‐level (e.g., Jimmy, Boris) or category‐level labels (e.g., Hitchel) while event‐related potentials were recorded in response to the onset of the visual stimulus in 6‐ (n = 41), 9‐ (n = 27), and 12‐month‐old (n = 28) infants. Analyses examined experience‐dependent visuocortical changes within and across trials, label conditions, and ages. Overall, results demonstrate that infants deploy greater visuocortical resources during the first half of associative learning trials and to stimuli paired with category‐level relative to individual‐level labels. Waveform morphologies also differed between stimuli paired with individual‐ and category‐level labels and across the age groups, with more complex deflections and amplitude differences between label type at 9‐ and 12‐month‐olds, but not 6‐month‐old infants. The present results highlight the importance of associative learning during infancy and suggest that category‐ versus individual‐level labels differentially direct infant attention and visuocortical processing.
Leveraging diverse cellular stress patterns for predicting clinical outcomes and therapeutic responses in patients with multiple myeloma
Authors: Xu Jiaxuan , Dong Xiaoqing , Dong Jiahui , Peng Yue , Xing Mengying , Chen Lanxin , Zhao Quan , Chen Bing 
Published: September 2024

AbstractTumour microenvironment harbours diverse stress factors that affect the progression of multiple myeloma (MM), and the survival of MM cells heavily relies on crucial stress pathways. However, the impact of cellular stress on clinical prognosis of MM patients remains largely unknown. This study aimed to provide a cell stress‐related model for survival and treatment prediction in MM. We incorporated five cell stress patterns including heat, oxidative, hypoxic, genotoxic, and endoplasmic reticulum stresses, to develop a comprehensive cellular stress index (CSI). Then we systematically analysed the effects of CSI on survival outcomes, clinical characteristics, immune microenvironment, and treatment sensitivity in MM. Molecular subtypes were identified using consensus clustering analysis based on CSI gene profiles. Moreover, a prognostic nomogram incorporating CSI was constructed and validated to aid in personalised risk stratification. After screening from five stress models, a CSI signature containing nine genes was established by Cox regression analyses and validated in three independent datasets. High CSI was significantly correlated with cell division pathways and poor clinical prognosis. Two distinct MM subtypes were identified through unsupervised clustering, showing significant differences in prognostic outcomes. The nomogram that combined CSI with clinical features exhibited good predictive performances in both training and validation cohorts. Meanwhile, CSI was closely associated with immune cell infiltration level and immune checkpoint gene expression. Therapeutically, patients with high CSI were more sensitive to bortezomib and antimitotic agents, while their response to immunotherapy was less favourable. Furthermore, in vitro experiments using cell lines and clinical samples verified the expression and function of key genes from CSI. The CSI signature could be a clinically applicable indicator of disease evaluation, demonstrating potential in predicting prognosis and guiding therapy for patients with MM.
Gene and cell therapy of human genetic diseases: Recent advances and future directions
Authors: Cetin Busra , Erendor Fulya , Eksi Yunus E. , Sanlioglu Ahter D. , Sanlioglu Salih 
Published: September 2024

AbstractDisruptions in normal development and the emergence of health conditions often result from the malfunction of vital genes in the human body. Decades of scientific research have focused on techniques to modify or substitute defective genes with healthy alternatives, marking a new era in disease treatment, prevention and cure. Recent strides in science and technology have reshaped our understanding of disorders, medication development and treatment recommendations, with human gene and cell therapy at the forefront of this transformative shift. Its primary objective is the modification of genes or adjustment of cell behaviour for therapeutic purposes. In this review, we focus on the latest advances in gene and cell therapy for treating human genetic diseases, with a particular emphasis on FDA and EMA‐approved therapies and the evolving landscape of genome editing. We examine the current state of innovative gene editing technologies, particularly the CRISPR‐Cas systems. As we explore the progress, ethical considerations and prospects of these innovations, we gain insight into their potential to revolutionize the treatment of genetic diseases, along with a discussion of the challenges associated with their regulatory pathways. This review traces the origins and evolution of these therapies, from conceptual ideas to practical clinical applications, marking a significant milestone in the field of medical science.
Linoleyl acetate and mandenol alleviate HUA‐induced ED via NLRP3 inflammasome and JAK2/STAT3 signalling conduction in rats
Authors: Ge Pingyu , Xie Hong , Guo Yinxue , Jin Hang , Chen Lan , Chen Zhichao , Liu Yan 
Published: September 2024

AbstractHyperuricemia (HUA) is characterized by elevated blood uric acid levels, which can increase the risk of erectile dysfunction (ED). Clinical studies have demonstrated satisfactory efficacy of a traditional Chinese medicine formula QYHT decoction in improving ED. Furthermore, the main monomeric components of this formula, linoleyl acetate and mandenol, demonstrate promise in the treatment of ED. This study established an ED rat model induced by HUA and the animals were administered with linoleyl acetate and mandenol. HE and TUNEL were performed to detect tissue changes, ELISA to measure the levels of serum testosterone (T), MDA, NO, CRP, and TNF‐α and qPCR and WB to assess the expression levels of NLRP3, ASC, Caspase‐1, JAK2, and STAT3 in whole blood. The findings showed that linoleyl acetate and mandenol improved kidney tissue morphology, reduced cell apoptosis in penile tissue, significantly increased T and NO levels, while substantially decreasing levels of MDA, CRP, and TNF‐α. Meanwhile, the expression of NLRP3, ASC, and Caspase‐1 mRNAs and proteins was markedly reduced, and the phosphorylation of JAK2 and STAT3 was inhibited. These findings were further validated through faecal microbiota transplantation results. Taken together, linoleyl acetate and mandenol could inhibit NLRP3 inflammasome activation, reduce inflammatory and oxidative stress responses, suppress the activity of JAK–STAT signalling pathway, ultimately providing a potential treatment for HUA‐induced ED.
Machine learning methods to discover hidden patterns in well‐being and resilience for healthy aging
Authors: Austin Robin R. , Jantraporn Ratchada , Michalowski Martin , Marquard Jenna 
Published: September 2024

AbstractBackgroundA whole person approach to healthy aging can provide insight into social factors that may be critical. Digital technologies, such as mobile health (mHealth) applications, hold promise to provide novel insights for healthy aging and the ability to collect data between clinical care visits. Machine learning/artificial intelligence methods have the potential to uncover insights into healthy aging. Nurses and nurse informaticians have a unique lens to shape the future use of this technology.MethodsThe purpose of this research was to apply machine learning methods to MyStrengths+MyHealth de‐identified data (N = 988) for adults 45 years of age and older. An exploratory data analysis process guided this work.ResultsOverall (n = 988), the average Strength was 66.1% (SD = 5.1), average Challenges 66.5% (SD = 7.5), and average Needs 60.06% (SD = 3.1). There was a significant difference between Strengths and Needs (p < 0.001), between Challenges and Needs (p < 0.001), and no significant differences between average Strengths and Challenges. Four concept groups were identified from the data (Thinking, Moving, Emotions, and Sleeping). The Thinking group had the most statistically significant challenges (11) associated with having at least one Thinking Challenge and the highest average Strengths (66.5%) and Needs (83.6%) compared to the other groups.ConclusionThis retrospective analysis applied machine learning methods to de‐identified whole person health resilience data from the MSMH application. Adults 45 and older had many Strengths despite numerous Challenges and Needs. The Thinking group had the highest Strengths, Challenges, and Needs, which aligns with the literature and highlights the co‐occurring health challenges experienced by this group. Machine learning methods applied to consumer health data identify unique insights applicable to specific conditions (e.g., cognitive) and healthy aging. The next steps involve testing personalized interventions with nurses leading artificial intelligence integration into clinical care.
Dermatological Health in the Light of Skin Microbiome Evolution
Authors: Haykal Diala , Cartier Hugues , Dréno Brigitte 
Published: September 2024

ABSTRACTBackgroundThe complex ecosystem of the skin microbiome is essential for skin health by acting as a primary defense against infections, regulating immune responses, and maintaining barrier integrity. This literature review aims to consolidate existing information on the skin microbiome, focusing on its composition, functionality, importance, and its impact on skin aging.MethodsAn exhaustive exploration of scholarly literature was performed utilizing electronic databases including PubMed, Google Scholar, and ResearchGate, focusing on studies published between 2011 and 2024. Keywords included “skin microbiome,” “skin microbiota,” and “aging skin.” Studies involving human subjects that focused on the skin microbiome's relationship with skin health were included. Out of 100 initially identified studies, 70 met the inclusion criteria and were reviewed.ResultsStudies showed that aging is associated with a reduction in the variety of microorganisms of the skin microbiome, leading to an increased susceptibility to skin conditions. Consequently, this underlines the interest in bacteriotherapy, mainly topical probiotics, to reinforce the skin microbiome in older adults, suggesting improvements in skin health and a reduction in age‐related skin conditions. Further exploration is needed into the microbiome's role in skin health and the development of innovative, microbe‐based skincare products. Biotherapeutic approaches, including the use of phages, endolysins, probiotics, prebiotics, postbiotics, and microbiome transplantation, can restore balance and enhance skin health. This article also addresses regulatory standards in the EU and the USA that ensure the safety and effectiveness of microbial skincare products.ConclusionThis review underscores the need to advance research on the skin microbiome's role in cosmetic enhancements and tailored skincare solutions, highlighting a great interest in leveraging microbial communities for dermatological benefits.
Disentangling the directionality among cultural stressors and psychosocial outcomes in recently immigrated Hispanic families: A random intercept cross‐lagged panel model approach
Authors: Ertanir Beyhan , Meca Alan , Cobb Cory , Zeledon Ingrid , Unger Jennifer B. , Lorenzo‐Blanco Elma , Montero‐Zamora Pablo , Zamboanga Byron L. , Baezconde‐Garbanati Lourdes , Soto Daniel W. , Aksoy Dilan , Kassis Wassilis , Duque Maria , Alpysbekova Aigerim , Schwartz Seth J. 
Published: September 2024

AbstractResearch shows the impact of cultural stressors (e.g. perceived discrimination, bicultural stressors, negative context of reception) on adolescents' psychosocial outcomes. Given the presence of multiple cultural stressors in many Hispanic adolescents' lives, it is essential to examine the (a) developmental sequencing of cultural stressors among recent immigrant youth and (b) predictive effects of cultural stressors on adolescents' psychosocial outcomes. We employed a random intercept cross‐lagged panel model to examine the longitudinal interplay among cultural stressors and their effects on youth outcomes using longitudinal data with six waves among 302 recently immigrated Hispanic adolescents (47% girls, Mage = 14.51, SD = .88). We observed bidirectional within‐person relations and between‐person associations among cultural stressors. At the within‐person level, bidirectional cross‐lagged effects emerged between perceived discrimination and bicultural stress, between perceived discrimination and negative context of reception, and between negative context of reception and bicultural stress. At the between‐person level, bidirectional cross‐lagged effects emerged only between perceived discrimination and bicultural stressors. Our findings indicate that cultural stressors explain heterogeneity in psychosocial outcomes: self‐esteem was inversely predicted by all cultural stressors, whereas depressive symptoms were predicted only by perceived discrimination. In addition, optimism was predicted only by bicultural stressors, and externalizing behavior was predicted by both bicultural stressors and perceived discrimination. These results suggest that the longitudinal relationships among cultural stressors are (partly) bidirectional. Additionally, cultural stressors demonstrated differential predictive effects on psychosocial outcomes, indicating the added value of considering multiple cultural stressors and their longitudinal effects on adolescents' psychosocial outcomes.
Periodontitis prevalence and acceleration of biological aging: Insights from NHANES 2009–2014 and Mendelian randomization study
Authors: Song Lin , Wang Yifan , Zheng Qiwen , Li Wenjing 
Published: September 2024

AbstractAimThis study aimed to investigate the association of periodontitis with biological aging and to assess potential causality using Mendelian randomization (MR).MethodsA cross‐sectional study with 9558 participants from the National Health and Nutrition Examination Survey (2009–2014) was conducted. Age acceleration (BioAgeAccel and PhenoAgeAccel) was calculated from clinical biomarkers and their discrepancies with chronological age. Two‐sample MR analysis was performed using data from a large‐scale genome‐wide association study and UK Biobank.ResultsPeriodontitis was associated with increased biological aging, with 0.57‐year (95% CI: 0.28–0.86, p < .001) increases in BioAgeAccel and 0.41‐year (95% CI: 0.04–0.78, p = .034) increases in PhenoAgeAccel. Subgroup analysis found significantly stronger associations in males for BioAgeAccele (PINTERACTION = .006), and pronounced associations in young adults (pinteraction = .023), individuals with normal body mass index (pinteraction = .015), and current smokers (pinteraction = .016) for PehonAgeAccel. MR analysis did not provide strong evidence for a causal effect of periodontitis on biological aging (BioAgeAccel: IVW β = 0.008, 95% CI: −0.018 to 0.034, p = .553 and PhenoAgeAccel: IVW β = 0.016, 95% CI: −0.042 to 0.074, p = .585).ConclusionThis study identified the association of periodontitis and its severity with accelerated aging, suggesting periodontal health could be a possible method in personalized preventive and therapeutic strategies of biological aging.
Exploring the impact of oil revenue on Nigeria's economic growth: A non‐linear autoregressive distributed lag model
Authors: Popoola Olufunke Mercy , Mutai Noah Cheruiyot , Dervishaj Valdrin , Nguyen Cuong Manh , Kumari Sushma , Bhatia Gunjan 
Published: September 2024

AbstractThe influence of oil proceeds on an economy remains a subject of debate among scholars. Most scholars agree that income from oil has direct effect on economic expansion. We explore the impact of revenue from oil on economic growth in Nigeria from 1986 to 2016. Data were collected from the Nigerian Central Bank and the World Data Indicators. We employed a non‐linear autoregressive distributive lag approach to analyse the data. The outcome exposes a direct and significant association between revenue from oil and GDP both in the short and long term. Trade openness exhibits a significant negative effect on GDP from both short‐ and long‐term perspectives. Gross capital formation directly influences GDP in the short and long run, with significant impacts primarily in the long term. The study suggests that revenue from oil has a direct and significant impact on the Nigerian economy during the period from 1981 to 2016. We recommend that the Nigerian government create a conducive environment for private investment to thrive, thereby sustaining the nation's growth potential. Additionally, the government should wisely utilise revenue from oil to revitalise non‐booming productive sectors in the economy, thus diversifying revenue sources.
MYB Transcription Factor CDC5 Activates CBF3 Expression to Positively Regulate Freezing Tolerance via Cooperating With ICE1 and Histone Modification in Arabidopsis
Authors: Xin Xin , Wang Shu , Pan Yunjiao , Ye Linhan , Zhai Tingting , Gu Mengjie , Wang Yanjiao , Zhang Jiedao , Li Xiang , Yang Wei , Zhang Shuxin 
Published: September 2024

ABSTRACTThe freezing temperature greatly limits the growth, development and productivity of plants. The C‐repeat/DRE binding factor (CBF) plays a major role in cold acclimation, enabling plants to increase their freezing tolerance. Notably, the INDUCER OF CBF EXPRESSION1 (ICE1) protein has garnered attention for its pivotal role in bolstering plants' resilience against freezing through transcriptional upregulation of DREB1A/CBF3. However, the research on the interaction between ICE1 and other transcription factors and its function in regulating cold stress tolerance is largely inadequate. In this study, we found that a R2R3 MYB transcription factor CDC5 interacts with ICE1 and regulates the expression of CBF3 by recruiting RNA polymerase II, overexpression of ICE1 can complements the freezing deficient phenotype of cdc5 mutant. CDC5 increases the expression of CBF3 in response to freezing. Furthermore, CDC5 influences the expression of CBF3 by altering the chromatin status through H3K4me3 and H3K27me3 modifications. Our work identified a novel component that regulates CBF3 transcription in both ICE1‐dependent and ICE1‐independent manner, improving the understanding of the freezing signal transduction in plants.
Facial Sebaceous Hyperplasia in an Adolescent With Hypohidrotic Ectodermal Dysplasia
Authors: Pinto‐Pulido Elena Lucía , Noguera‐Morel Lucero , Colmenero Isabel , Torrelo Antonio , Hernández‐Martín Ángela 
Published: September 2024

ABSTRACTWe report on a 13‐year‐old boy diagnosed with hypohidrotic ectodermal dysplasia (HED) due to a pathogenic variant in ectodysplasin A (EDA). He exhibited multiple whitish, millimetric papules clustered on the nasal ala, forehead, temporal, and zygomatic arch areas. Histological examination revealed numerous hyperplastic sebaceous lobules within the upper dermis. The occurrence of sebaceous papules in this distribution among HED patients has rarely been reported. An association with the blockage of the Wnt/β‐catenin pathway due to EDA malfunction has been speculated.
Species‐specific functional trait responses in two species coexisting along a shore‐to‐inland dune gradient
Authors: Bermúdez R. , Sánchez Vilas J. , Retuerto R. 
Published: September 2024

Abstract
Coastal dunes are characterised by strong gradients of abiotic stress, typically increasing in severity from inland areas towards the shoreline. Thus, dune gradients represent unique opportunities to study intraspecific responses to environmental changes and to investigate which factors drive community change. This study aims to examine functional trait variation in two coexisting species in response to environmental changes along a dune gradient in NW Spain. Trait convergence was also investigated and compared between both ends of the gradient.
We measured functional leaf traits related to plant efficiency in the use of light, water and nutrients, also possible stressors (salt content and pH) and availability of limiting resources (water and nutrients) in the soil.
Most soil variables showed changes following a non‐directional gradient. Differences in soil variables were site specific and depended on growth of the study species. Structural and functional traits depended on species and/or plant position on the gradient, except for effective quantum yield of PSII and leaf δ15N. The pattern of variation was mostly directional for reflectance indices related to leaf physiology. Multivariate analyses showed significant interspecific differences in the set of traits they exhibited along positions in the gradient. Species also differed in the combination of traits selected under given environmental conditions.
Coexisting species display a specific set of traits that reflects different strategies to environmental stress. Our study highlights the overly simplistic nature of some previous studies that assume dune gradients are monotonically directional, without considering that these gradients may be differentially modified by species activity.
Long‐term methylome changes after experimental seed demethylation and their interaction with recurrent water stress in Erodium cicutarium (Geraniaceae)
Authors: Balao F. , Medrano M. , Bazaga P. , Paun O. , Alonso C. 
Published: September 2024

Abstract
The frequencies and lengths of drought periods are increasing in subtropical and temperate regions worldwide. Epigenetic responses to water stress could be key for plant resilience to these largely unpredictable challenges. Experimental DNA demethylation, together with application of a stress factor is an appropriate strategy to reveal the contribution of epigenetics to plant responses to stress.
We analysed leaf cytosine methylation changes in adult plants of the annual Mediterranean herb, Erodium cicutarium, in a greenhouse, after seed demethylation with 5‐Azacytidine and/or recurrent water stress. We used bisulfite RADseq (BsRADseq) and a newly reported reference genome for E. cicutarium to characterize methylation changes in a 2 × 2 factorial design, controlling for plant relatedness.
In the long term, 5‐Azacytidine treatment alone caused both hypo‐ and hyper‐methylation at individual cytosines, with substantial hypomethylation in CG contexts. In control conditions, drought resulted in a decrease in methylation in all but CHH contexts. In contrast, the genome of plants that experienced recurrent water stress and had been treated with 5‐Azacytidine increased DNA methylation level by ca. 5%.
Seed demethylation and recurrent drought produced a highly significant interaction in terms of global and context‐specific cytosine methylation. Most methylation changes occurred around genic regions and within Transposable Elements. The annotation of these Differentially Methylated Regions associated with genes included several with a potential role in stress responses (e.g., PAL, CDKC, and ABCF), confirming an epigenetic contribution in response to stress at the molecular level.