bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxindole–benzothiazole hybrids as CDK2 inhibitors and anticancer agents: design, synthesis and biological evaluation
Authors: Abdel-Mohsen Heba T. 
Published: September 2024

AbstractIn the current study, molecular hybridization between the oxindole core and benzothiazole system through an acetohydrazide moiety was accomplished for the design of a new series of oxindole–benzothiazole hybrids 9a–r targeting CDK2 for cancer therapy. The afforded hybrids displayed promising growth inhibitory activity on NCI cancer cell lines at 10 µM. Compound 9o displayed mean GI% = 55.91%. Based on the potent activity of 9o, it was further assessed for its cytotoxic activity at five dose level and it demonstrated GI50 reaching 2.02 µM. Analysis of the cell cycle of the prostate cancer cell line DU145 after treatment with 9o confirmed its ability to arrest its cell cycle at the G1 phase. Moreover, 9o proved its ability to potentiate the apoptosis and necrosis of the same cell line. Furthermore, the oxindole–benzothiazole hybrids 9b, 9f and 9o showed IC50 = 0.70, 0.20 and 0.21 µM, respectively on CDK2. Besides, molecular docking simulation of the synthesized oxindole–benzothiazole hybrid 9o proved the expected binding mode which involves the accommodation of the oxindole moiety in the ATP binding pocket where it is involved in hydrogen bonding and hydrophobic interactions with the essential amino acids in the hinge region while the benzothiazole moiety is oriented toward the solvent region. Investigation of the physicochemical properties of the hybrids 9a–r highlights their acceptable ADME properties that can be somewhat developed for the discovery of new anticancer agents.
Corrosion potential and theoretical studies of fabricated Schiff base for carbidic austempered ductile iron in 1M H2SO4 solution
Authors: Gaber Ghalia A. , Mohamed Lamiaa Z. , Aly Hayam A. , Hosny Shimaa 
Published: September 2024

AbstractIn this body of work, a chemical known as 2-cyano-N-(4-morpholino benzyl dine) acetohydrazide (CMBAH) is explored for its ability to suppress the carbidic austempered ductile iron (CADI) corrosion in 1M H2SO4. Density functional theory was used in experiments and theoretical investigations to investigate the inhibiting impact. The corrosion of CADI alloys in 1M H2SO4 produced a corrosion resistance superior to that of CADI heat treatment (H.T.). As-cast carbidic ductile iron (CDI) 4 alloy with 1.5%t Cr-Nb has a corrosion rate (C.R.) of 11.69 mm/year, which drops to 5.31 mm/year at HT-275 °C and 6.13 mm/year at HT-375 °C. When describing the adsorption of inhibitors, the Langmuir adsorption isotherm is the most effective method. The findings of the Gads show that the inhibition was induced mainly by the physisorption on the surface CADI alloys. In addition to this, it was found that the results of the experiments and the hypotheses were largely harmonious with one another. The formation of protective layers on the CADI surfaces is also visible in the images captured by the SEM. In 1M H2SO4, these Schiff base inhibitors effectively prevent corrosion caused by CADI. However, the combination of inhibitors leads to a fine microstructure with ausferrite and narrow ferrite needles, promoting corrosion resistance. The CADI needles rated an upper ausferritic microstructure with wide ferrite needles.
Myocardial infarction with non-obstructive coronary arteries in a young seropositive woman with human immunodeficiency virus: a case report and review of the literature
Authors: Boumaaz Meriem , Faraj Raid , Reggad Ahmed , Lakhal Zouhair , Asfalou Iliyasse 
Published: September 2024

Abstract
Background
Elevated susceptibility to acute myocardial infarction and various cardiovascular diseases has been observed in individuals infected with the human immunodeficiency virus compared with the uninfected population, as demonstrated in numerous studies. The precise mechanism by which human immunodeficiency virus infection heightens the risk of acute myocardial infarction remains elusive. The manifestation of acute coronary syndrome in young patients with human immunodeficiency virus may deviate from the typical, displaying distinct pathophysiological and clinical characteristics. The occurrence of myocardial infarction with non-obstructive coronary arteries in young patients with human immunodeficiency virus poses diagnostic and treatment challenges.

Case presentation
We present the case of a 46-year-old African woman with no traditional atherosclerotic risk factors. She was diagnosed with human immunodeficiency virus-1 infection 2 years prior to her current admission for chest pain. Her troponin levels were elevated, suggestive of acute coronary syndrome. Although coronary angiography ruled out coronary artery stenosis, it revealed mild myocardial bridging in the left anterior descending artery. Cardiac magnetic resonance imaging confirmed myocardial infarction, indicating a myocardial infarction with non-obstructive coronary arteries with an apical thrombus in the left ventricle. Following medical treatment, the patient experienced resolution of chest pain and improvement in ST-segment elevation.

Conclusions
In young female patients without traditional risk factors, human immunodeficiency virus infection is a possible etiological factor for myocardial infarction with non-obstructive coronary arteries. The likely pathophysiological pathway is superficial endothelial cell denudation as a result of chronic inflammation and immune activation.
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment
Authors: Zhou Shishan , Liu Shujie , Jiang Anfeng , Li Zhiyuan , Duan Chaojun , Li Bin 
Published: September 2024

AbstractImmune cells-enhanced immunotherapy exhibits unprecedented overall survival-prolongation even curable in some cancer patients. Although so, most of the patients show no response. Tumor microenvironment (TME) where immune cells settle down has multi-faceted influences, but usually creates an immunosuppressive niche that facilitating tumor cells escape from immune attack. The metabolites and malnutrition of TME exert enormous effects on the resident immune cells, but the underlying mechanism is largely unknown. The stromal interaction molecules 2 (STIM2) is an endoplasmic reticulum (ER) calcium (Ca2+) sensor to maintain Ca2+ homeostasis. Notably, the cytosol STIM2 C-terminus is long with various domains that are available for the combination or/and molecular modification. This distinct structure endows STIM2 with a high susceptibility to numerous permeable physico-chemical molecules or protein interactions. STIM2 and its variants are extensively expressed in various immune cells, especially in T immune cells. STIM2 was reported closely correlated with the function of immune cells via regulating Ca2+ signaling, energy metabolism and cell fitness. Herein, we sum the latest findings on the STIM2 structure, focusing on its distinct characteristics and profound effect on the regulation of Ca2+ homeostasis and multi-talented functionality. We also outline the advancements on the underlying mechanism how STIM2 anomalies influence the function of immune cells and on the turbulent expression or/and amenably modification of STIM2 within the tumor niches. Then we discuss the translation of these researches into antitumor approaches, emphasizing the potential of STIM2 as a therapeutic target for direct inhibition of tumor cells or more activation towards immune cells driving to flare TME. This review is an update on STIM2, aiming to rationalize the potential of STIM2 as a therapeutic target for immunomodulation, engaging immune cells to exert the utmost anti-tumor effect.
Assessing infection prevention and control structures in German hospitals after the COVID-19 pandemic using the WHO infection prevention and control assessment framework (IPCAF): results from 660 hospitals and comparison with a pre-pandemic survey
Authors: Rüther Ferenc Darius , Gropmann Alexander , Hansen Sonja , Behnke Michael , Geffers Christine , Aghdassi Seven Johannes Sam 
Published: September 2024

Abstract
Background
The WHO Infection Prevention and Control Assessment Framework (IPCAF) is a standardized tool to assess infection prevention and control (IPC) structures in healthcare facilities. The IPCAF reflects the eight WHO core components (CC) of IPC. Besides facility self-assessment, the IPCAF can be used for national surveys, and repeated usage can aid in describing trends concerning IPC structures. A previous survey in over 700 German hospitals conducted in 2018, yielded an overall high IPC level in participating hospitals, albeit with potentials for improvement. In 2023, the survey was repeated to describe once again the state of IPC implementation in German hospitals and compare findings to data from 2018.

Methods
The German National Reference Center for the Surveillance of Nosocomial Infections (NRC) invited 1,530 German acute care hospitals participating in the national surveillance network “KISS”, to complete a translated online version of the IPCAF between October 2023 and January 2024. The questionnaire-like nature of the IPCAF, where each answer corresponds to a number of points, allows for calculating an overall IPC score. Based on the overall score, hospitals were allocated to four different IPC levels: inadequate (0–200), basic (201–400), intermediate (401–600), and advanced (601–800). Aggregated scores were calculated and compared with results from 2018.

Results
Complete datasets from 660 hospitals were received and analyzed. The median overall IPCAF score was 692.5 (interquartile range: 642.5–737.5), with 572 hospitals (86.6%) classified as advanced, and 87 hospitals (13.2%) as intermediate. One hospital (0.2%) fell into the basic category. The overall median score was virtually unchanged when compared to 2018 (690; data from 736 hospitals). The median score for the CC on workload, staffing and bed occupancy was markedly higher (85 vs. 75), whereas the median score for the CC on multimodal strategies was slightly lower than in 2018 (75 vs. 80).

Conclusions
Repeated assessments of IPC structures at the national level with the IPCAF are feasible and a means to gain insights into the evolution of IPC structures. When comparing aggregated scores, a stable and high level of IPC key aspects in Germany was observed, with improvements over time in IPC indicators related to workload and staffing.
Optimization of fermentation conditions, physicochemical profile and sensory quality analysis of seedless wampee wine
Authors: Wang Hong , Liao Xiang , Lin Chunyao , Bai Weidong , Xiao Gengsheng , Huang Xingyuan , Liu Gongliang 
Published: September 2024

AbstractThe aims of the present stud were to optimize fermentation parameters of seedless wampee wine using response surface methodology (RSM) and evaluate the changes in flavor metabolites during fermentation. Seedless wampee wine of optimal sensory quality was produced using an inoculum concentration of 0.6%, initial sugar levels of 200 g/L, a fermentation temperature of 22 °C, and a fermentation period of 9 days. Then the flavor compound profiles (amino acids, organic acids and volatile aroma compounds) of seedless wampee wine during the fermentation under optimal conditions were analyzed using high performance liquid chromatography (HPLC) and gas chromatography–mass spectrometr (GC-MS). The main fermented phase of fermentation resulted in fluctuations in both total amino acids and organic acids, with stabilization occurring later on. A total of 54 volatile components, including esters, alcohols, terpenes, and acids, were putatively identified. Terpenes were the primary drivers of the flavor characteristics of seedless wampee. The rise of esters and decline of terpenes have the potential to significantly alter the flavor of wine during fermentation. These results would contribute to the further development of seedless wampee wine.
Graphical Abstract
No significant difference in salivary cortisol response on the Trier Social Stress Test-Online based on coffee consumption habits
Authors: Ueno Masaharu 
Published: September 2024

Abstract
Background
Coffee is widely consumed around the world. In Japan, it is a type of “Shikohin” (consumed for flavor, not nutrition). Several medical studies have reported the beneficial effects of coffee consumption, whereas others suggest that these beneficial effects on psychological aspects are marginal. The habit of consuming large amounts of caffeine through coffee may improve short-term resilience in stressful situations and may exhaust individuals in the long term. We hypothesized that people who habitually drink high amounts of coffee would have lower resilience scores and higher acute stress responses.

Methods
Adult Japanese men completed a questionnaire that included a resilience scale and Shikohin consumption habits. Experimental participants were recruited from the survey respondents and classified into three groups based on their coffee consumption per day: No Coffee, Low Coffee, and High Coffee. All participants were asked to join the Trier Social Stress Test-Online (TSST-OL). Subjective stress and salivary cortisol concentrations was measured at eight time points during the experiment. There were 16 participants in each group for the analysis (mean age = 46.10 years, SD = 12.58).

Results
Statistical analysis showed that both subjective stress and salivary cortisol concentrations significantly increased following TSST-OL exposure. However, there were no significant differences among the groups, and the hypotheses were not supported.

Conclusions
This study demonstrated the effectiveness and stability of the TSST-OL. Additionally, coffee consumption habits were not significantly related to resilience scale scores or acute stress responses.
Social media ostracism and creativity: moderating role of emotional intelligence
Authors: Amin Muhammad Waqas , Wang Jiuhe 
Published: September 2024

AbstractThe goal of this study is to learn more about social media ostracism, a stressor associated with online social networks, defined by feelings of rejection, exclusion, or ignoring. We investigate the connection between social media ostracism and worker creativity. We suggest that psychological safety and psychological rumination serve as intermediaries in this relationship. Furthermore, we investigate emotional intelligence as a relationship regulator. To verify our hypothesis, we gathered data with the help of the HR department from 244 workers of nine Chinese organizations. Our research shows that psychological rumination and social media exclusion are significantly correlated, but only in workers with low emotional intelligence. Furthermore, for individuals with strong emotional intelligence, we did not discover a statistically negative association between psychological safety and social media exclusion. Findings suggest that psychological safety and psychological rumination serve as mediating factors in the relationship between employee creativity and social media exclusion. This study illuminates the negative aspects of social media ostracism and reveals how it might hinder creativity. It also emphasizes how emotional intelligence functions as a moderator. Organizations may learn a lot from this study on how to lessen the negative impacts of social media exclusion on employee creativity.
Extracorporeal cardiopulmonary resuscitation: a comparison of two experimental approaches and systematic review of experimental models
Authors: Moreau Anthony , Su Fuhong , Annoni Filippo , Taccone Fabio Silvio 
Published: September 2024

Abstract
Background
In patients requiring extracorporeal cardiopulmonary resuscitation (ECPR), there is a need for studies to assess the potential benefits of therapeutic interventions to improve survival and reduce hypoxic-ischemic brain injuries. However, conducting human studies may be challenging. This study aimed to describe two experimental models developed in our laboratory and to conduct a systematic review of existing animal models of ECPR reported in the literature.

Results
In our experiments, pigs were subjected to 12 min (model 1) or 5 min (model 2) of untreated ventricular fibrillation, followed by 18 min (model 1) or 25 min (model 2) of conventional cardiopulmonary resuscitation. Results showed severe distributive shock, decreased brain oxygen pressure and increased intracranial pressure, with model 1 displaying more pronounced brain perfusion impairment. A systematic review of 52 studies, mostly conducted on pigs, revealed heterogeneity in cardiac arrest induction methods, cardiopulmonary resuscitation strategies, and evaluated outcomes.

Conclusions
This review emphasizes the significant impact of no-flow and low-flow durations on brain injury severity following ECPR. However, the diversity in experimental models hinders direct comparisons, urging the standardization of ECPR models to enhance consistency and comparability across studies.
Prediction of axillary lymph node metastasis using a magnetic resonance imaging radiomics model of invasive breast cancer primary tumor
Authors: Shi Wei , Su Yingshi , Zhang Rui , Xia Wei , Lian Zhenqiang , Mao Ning , Wang Yanyu , Zhang Anqin , Gao Xin , Zhang Yan 
Published: September 2024

Abstract
Background
This study investigated the clinical value of breast magnetic resonance imaging (MRI) radiomics for predicting axillary lymph node metastasis (ALNM) and to compare the discriminative abilities of different combinations of MRI sequences.

Methods
This study included 141 patients diagnosed with invasive breast cancer from two centers (center 1: n = 101, center 2: n = 40). Patients from center 1 were randomly divided into training set and test set 1. Patients from center 2 were assigned to the test set 2. All participants underwent preoperative MRI, and four distinct MRI sequences were obtained. The volume of interest (VOI) of the breast tumor was delineated on the dynamic contrast-enhanced (DCE) postcontrast phase 2 sequence, and the VOIs of other sequences were adjusted when required. Subsequently, radiomics features were extracted from the VOIs using an open-source package. Both single- and multisequence radiomics models were constructed using the logistic regression method in the training set. The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, and precision of the radiomics model for the test set 1 and test set 2 were calculated. Finally, the diagnostic performance of each model was compared with the diagnostic level of junior and senior radiologists.

Results
The single-sequence ALNM classifier derived from DCE postcontrast phase 1 had the best performance for both test set 1 (AUC = 0.891) and test set 2 (AUC = 0.619). The best-performing multisequence ALNM classifiers for both test set 1 (AUC = 0.910) and test set 2 (AUC = 0.717) were generated from DCE postcontrast phase 1, T2-weighted imaging, and diffusion-weighted imaging single-sequence ALNM classifiers. Both had a higher diagnostic level than the junior and senior radiologists.

Conclusions
The combination of DCE postcontrast phase 1, T2-weighted imaging, and diffusion-weighted imaging radiomics features had the best performance in predicting ALNM from breast cancer. Our study presents a well-performing and noninvasive tool for ALNM prediction in patients with breast cancer.
Anti-protein phosphatase magnesium-dependent 1A-IgM levels in patients with active ankylosing spondylitis: a potential biomarker
Authors: Lee Yeo-Jin , Lee Eun-Ju , Ahn Soo Min , Hong Seokchan , Oh Ji Seon , Lee Chang-Keun , Yoo Bin , Kim Yong-Gil 
Published: September 2024

Abstract
Background
Ankylosing spondylitis (AS) has been known to have auto-inflammatory nature; hence, the efficacy of autoantibodies is low. However, studies on autoantibodies are ongoing, with some studies showing associations. Previous studies showed that anti-protein phosphatase magnesium-dependent 1A (PPM1A) IgG was increased in patients with AS and associated with radiographic progression. However, the diagnostic usefulness was limited due to relatively low sensitivity and specificity. This pilot study evaluated the diagnostic utility of anti-PPM1A-IgM and anti-PPM1A-IgG in patients with active AS.

Methods
Serum samples were obtained from the registry cohort of a single tertiary center in Korea. Serum levels of anti-PPM1A-IgG/IgM were measured by direct ELISA. Receiver operating characteristic (ROC) analysis was used to predict the diagnostic sensitivity and specificity of serum anti-PPM1A-IgG/IgM.

Results
Samples were collected from 28 patients with active AS, 16 healthy controls (HCs), and 28 patients with rheumatoid arthritis (RA). Although total serum IgM was lower in the RA and AS groups than in the HC group, anti-PPM1A-IgM was significantly lower in the AS group than in the other groups. In evaluating the diagnostic utility of anti-PPM1A-IgG/IgM for AS patients compared with HCs, the area under the curve (AUC) of anti-PPM1A-IgM was 0.998 (sensitivity 96.4%, specificity 100.0%). When ROC analysis of anti-PPM1A-IgM for AS patients compared with RA patients was conducted, sensitivity was 78.6% and specificity was 71.4%, with an AUC of 0.839.

Conclusion
Decreased anti-PPM1A-IgM levels in AS patients suggests a potential role for anti-PPM1A-IgM in the diagnosis of active AS.
Impacts of language barriers on perceived quality of care in physical therapy: a systematic review
Authors: Neipert Avery , Russo Kallista , Ortt Sarah , Scott Graycen , Mierzwicki Justin 
Published: September 2024

Abstract
Introduction
Language barriers are prevalent across growing societies and are likely to become a larger issue with further population growth. Language barriers impair communication between patients and physical therapists. This systematic review addresses how language barriers between patients and physical therapists impact clinicians’ perceived quality of care.

Methods
A stepwise search of databases based on key terms was conducted, followed by abstract and full-text screenings with inclusion and exclusion criteria. Eight articles were included in the final review.

Results
Screening processes resulted in the inclusion of eight articles from which abstracted information was sorted into six different categories. In total, six articles addressed overall clinical perception, four articles spoke of interpretive services, seven articles detailed methods of communication in practice, five articles on tests and measures, four articles on establishing rapport, and two articles factored cultural components.

Discussion
Collected information was analyzed within topics of patient interactions, interpretive services, visit mechanics, and clinician’s perception of self. These themes demonstrated that language barriers can negatively impact clinician-perceived care quality. Examples include limiting the collection of patient history, usage of standardized tests, and other aspects of best practice, ultimately hindering clinician autonomy.

Conclusion
There are benefits and disadvantages to communication methods used within clinical settings for therapists when negotiating language barriers. Legislation often states that interpretive services must be provided to patients but does not delineate specific guidelines. Governing bodies in physical therapy could provide more formalized guidelines and education to address language barriers in practice.