bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astigmatism Correction With Toric Intraocular Lenses in Descemet Membrane Endothelial Keratoplasty Triple Procedures
Authors: Yokogawa Hideaki , Sanchez P. James , Mayko Zachary M. , Straiko Michael D. , Terry Mark A. 
Published: December 2016

Purpose:
To report the clinical efficacy of astigmatism correction with toric intraocular lenses (IOLs) in patients undergoing the Descemet membrane endothelial keratoplasty (DMEK) triple procedure and to evaluate the accuracy of the correction.

Methods:
Fifteen eyes of 10 patients who received cataract extraction, toric IOL placement, and DMEK surgery for Fuchs corneal dystrophy and cataracts were evaluated. The cylinder power of toric IOLs was determined by an online toric calculator with keratoscopy measurements obtained using Scheimpflug corneal imaging. Prediction errors were assessed as a difference vector between the anticipated minus postoperative residual astigmatism.

Results:
At 10.1 ± 4.9 months postoperatively, 8/13 (61.5%) of eyes achieved uncorrected distance visual acuity better than 20/40. Mean best spectacle-corrected distance visual acuity (logMAR) improved from 0.21 ± 0.15 preoperatively to 0.08 ± 0.12 postoperatively (P < 0.01). The magnitude of refractive astigmatism was also significantly decreased from 2.23 ± 1.10 D (range 0.75–4.25 D) preoperatively to 0.87 ± 0.75 D (range 0.00–3.00 D) postoperatively (P < 0.01). In 1 eye with rotational misalignment by 43 degrees, we found no improvement of astigmatism. The prediction error of astigmatism at the corneal plane was 0.77 ± 0.54 D (range 0.10–1.77 D). Four eyes with preoperative “with-the-rule” corneal astigmatism had postoperative “against-the-rule” refractive astigmatism.

Conclusions:
For patients with Fuchs corneal dystrophy and cataracts, use of toric IOLs might be a valuable option in triple DMEK surgery. Additionally, care should be taken to prevent excessive IOL rotation.
Anesthesia for functional endoscopic sinus surgery
Authors: Carlton Daniel A. , Govindaraj Satish 
Published: December 2016

Purpose of review
The present article summarizes anesthetic techniques used during functional endoscopic sinus surgery to decrease bleeding and aid in creating a clear surgical field. The applicable physiology behind these anesthetic techniques is reviewed with emphasis on the effect on bleeding and the surgical field. Deliberate hypotension, reverse Trendelenburg positioning, regional anesthesia, and cerebral monitoring are discussed.

Recent findings
There are mixed data as to whether traditional inhalation anesthesia or total intravenous anesthesia is superior with respect to better surgical fields and decreased blood loss. A review of the literature tends to favor total intravenous anesthesia. Cerebral oximetry and transcranial Doppler ultrasound are emerging techniques to monitor cerebral perfusion during deliberate hypotension.

Summary
Total intravenous anesthesia using propofol and remifentanil is the current favored technique for producing deliberate hypotension during endoscopic sinus surgery due to its hemodynamic stability and smooth rapid emergence.
Field Evaluation of Dried Blood Spots for HIV-1 Viral Load Monitoring in Adults and Children Receiving Antiretroviral Treatment in Kenya: Implications for Scale-up in Resource-Limited Settings
Authors: Schmitz Mary E. , Agolory Simon , Junghae Muthoni , Broyles Laura N. , Kimeu Muthusi , Ombayo Joseph , Umuro Mamo , Mukui Irene , Alwenya Kennedy , Baraza Moses , Ndiege Kenneth , Mwalili Samuel , Rivadeneira Emilia , Ng'ang'a Lucy , Yang Chunfu , Zeh Clement ,   for VL-DBS Study Group
Published: December 2016

Background:
The World Health Organization recommends viral load (VL) as the preferred method for diagnosing antiretroviral therapy failure; however, operational challenges have hampered the implementation of VL monitoring in most resource-limited settings. This study evaluated the accuracy of dried blood spot (DBS) VL testing under field conditions as a practical alternative to plasma in determining virologic failure (VF).

Methods:
From May to December 2013, paired plasma and DBS specimens were collected from 416 adults and 377 children on antiretroviral therapy for ≥6 months at 12 clinics in Kenya. DBSs were prepared from venous blood (V-DBS) using disposable transfer pipettes and from finger-prick capillary blood using microcapillary tubes (M-DBS) and directly spotting (D-DBS). All samples were tested on the Abbott m2000 platform; V-DBS was also tested on the Roche COBAS Ampliprep/COBAS TaqMan (CAP/CTM) version 2.0 platform. VF results were compared at 3 DBS thresholds (≥1000, ≥3000, and ≥5000 copies/mL) and a constant plasma threshold of ≥1000 copies/mL.

Results:
On the Abbott platform, at ≥1000-copies/mL threshold, sensitivities, specificities, and kappa values for VF determination were ≥88.1%, ≥93.1%, and ≥0.82%, respectively, for all DBS methods, and it had the lowest percentage of downward misclassification compared with higher thresholds. V-DBS performance on CAP/CTM had significantly poorer specificity at all thresholds (1000%–33.0%, 3000%–60.9%, and 5000%–77.0%). No significant differences were found between adults and children.

Conclusions:
VL results from V-DBS, M-DBS, and D-DBS were comparable with those from plasma for determining VF using the Abbott platform but not with CAP/CTM. A 1000-copies/mL threshold was optimal and should be considered for VF determination using DBS in adults and children.
Sex Differences in Tobacco Use Among Persons Living With HIV/AIDS: A Systematic Review and Meta-Analysis
Authors: Weinberger Andrea H. , Smith Philip H. , Funk Allison P. , Rabin Shayna , Shuter Jonathan 
Published: December 2016

Background:
Persons living with HIV/AIDS (PLWH) smoke at higher rates than other adults and experience HIV-related and non-HIV–related adverse smoking consequences. This study conducted a systematic review to synthesize current knowledge about sex differences in smoking behaviors among PLWH.

Methods:
Over 3000 abstracts from MEDLINE were reviewed and 79 publications met all the review inclusion criteria (ie, reported data on smoking behaviors for PLWH by sex). Sufficient data were available to conduct a meta-analysis for one smoking variable: current smoking prevalence.

Results:
Across studies (n = 51), the meta-analytic prevalence of current smoking among female PLWH was 36.3% (95% confidence interval [CI]: 28.0% to 45.4%) and male PLWH was 50.3% (95% CI: 44.4% to 56.2%; meta-analytic odds ratio = 1.78, 95% CI: 1.29 to 2.45). When analyses were repeated just on the US studies (n = 23), the prevalence of current smoking was not significantly different for female PLWH (55.1%, 95% CI: 47.6% to 62.5%) compared with male PLWH (55.5%, 95% CI: 48.2% to 62.5%; meta-analytic odds ratio = 1.04, 95% CI: 0.86 to 1.26). Few studies reported data by sex for other smoking variables (eg, quit attempts, noncigarette tobacco product use) and results for many variables were mixed.

Discussion:
Unlike the general US population, there was no difference in smoking prevalence for female versus male PLWH (both >50%) indicating that HIV infection status was associated with a greater relative increase in smoking for women than men. More research is needed in all areas of smoking behavior of PLWH to understand similarities and differences by sex to provide the best interventions to reduce the high smoking prevalence for all sexes.
Metabolic roles of uncultivated bacterioplankton lineages in the northern Gulf of Mexico “Dead Zone”
Authors: Thrash J. Cameron , Seitz Kiley W. , Baker Brett J. , Temperton Ben , Gillies Lauren E. , Rabalais Nancy N. , Henrissat Bernard , Mason Olivia U. 
Published: December 2016

AbstractMarine regions that have seasonal to long-term low dissolved oxygen (DO) concentrations, sometimes called ‘dead zones,’ are increasing in number and severity around the globe with deleterious effects on ecology and economics. One of the largest of these coastal dead zones occurs on the continental shelf of the northern Gulf of Mexico (nGOM), which results from eutrophication-enhanced bacterioplankton respiration and strong seasonal stratification. Previous research in this dead zone revealed the presence of multiple cosmopolitan bacterioplankton lineages that have eluded cultivation, and thus their metabolic roles in this ecosystem remain unknown. We used a coupled shotgun metagenomic and metatranscriptomic approach to determine the metabolic potential of Marine Group II Euryarchaeota, SAR406, and SAR202. We recovered multiple high-quality, nearly complete genomes from all three groups as well as those belonging to Candidate Phyla usually associated with anoxic environments-Parcubacteria (OD1) and Peregrinibacteria. Two additional groups with putative assignments to ACD39 and PAUC34f supplement the metabolic contributions by uncultivated taxa. Our results indicate active metabolism in all groups, including prevalent aerobic respiration, with concurrent expression of genes for nitrate reduction in SAR406 and SAR202, and dissimilatory nitrite reduction to ammonia and sulfur reduction by SAR406. We also report a variety of active heterotrophic carbon processing mechanisms, including degradation of complex carbohydrate compounds by SAR406, SAR202, ACD39, and PAUC34f. Together, these data help constrain the metabolic contributions from uncultivated groups in the nGOM during periods of low DO and suggest roles for these organisms in the breakdown of complex organic matter.ImportanceDead zones receive their name primarily from the reduction of eukaryotic macrobiota (demersal fish, shrimp, etc.) that are also key coastal fisheries. Excess nutrients contributed from anthropogenic activity such as fertilizer runoff result in algal blooms and therefore ample new carbon for aerobic microbial metabolism. Combined with strong stratification, microbial respiration reduces oxygen in shelf bottom waters to levels unfit for many animals (termed hypoxia). The nGOM shelf remains one of the largest eutrophication-driven hypoxic zones in the world, yet despite its potential as a model study system, the microbial metabolisms underlying and resulting from this phenomenon—many of which occur in bacterioplankton from poorly understood lineages—have received only preliminary study. Our work details the metabolic potential and gene expression activity for uncultivated lineages across several low DO sites in the nGOM, improving our understanding of the active biogeochemical cycling mediated by these “microbial dark matter” taxa during hypoxia.
Multivariate pattern analysis of MEG and EEG: a comparison of representational structure in time and space
Authors: Cichy Radoslaw Martin , Pantazis Dimitrios 
Published: December 2016

1AbstractMultivariate pattern analysis of magnetoencephalography (MEG) and electroencephalography (EEG) data can reveal the rapid neural dynamics underlying cognition. However, MEG and EEG have systematic differences in sampling neural activity. This poses the question to which degree such measurement differences consistently bias the results of multivariate analysis applied to MEG and EEG activation patterns. To investigate, we conducted a concurrent MEG/EEG study while participants viewed images of everyday objects. We applied multivariate classification analyses to MEG and EEG data, and compared the resulting time courses to each other, and to fMRI data for an independent evaluation in space. We found that both MEG and EEG revealed the millisecond spatio-temporal dynamics of visual processing with largely equivalent results. Beyond yielding convergent results, we found that MEG and EEG also captured partly unique aspects of visual representations. Those unique components emerged earlier in time for MEG than for EEG. Identifying the sources of those unique components with fMRI, we found the locus for both MEG and EEG in high-level visual cortex, and in addition for MEG in early visual cortex. Together, our results show that multivariate analyses of MEG and EEG data offer a convergent and complimentary view on neural processing, and motivate the wider adoption of these methods in both MEG and EEG research.
Cleanliness in context: reconciling hygiene with a modern microbial perspective
Authors: Vandegrift Roo , Bateman Ashley C. , Siemens Kyla N. , Nguyen May , Green Jessica L. , Van Den Wymelenberg Kevin G. , Hickey Roxana J. 
Published: December 2016

AbstractThe concept of hygiene is rooted in the relationship between cleanliness and the maintenance of good health. Since the widespread acceptance of the germ theory of disease, hygiene has become increasingly conflated with that of sterilization. Recent research on microbial ecology is demonstrating that humans have intimate and evolutionarily significant relationships with a diverse assemblage of microorganisms (ourmicrobiota). Human skin is home to a diverse, skin habitat specific community of microorganisms; this includes members that exist across the ecological spectrum from pathogen through commensal to mutualist. Most evidence suggests that the skin microbiota is likely of direct benefit to the host, and only rarely exhibits pathogenicity. This complex ecological context suggests that the conception of hygiene as a unilateral reduction or removal of microbes has outlived its usefulness. As such, we suggest the explicit definition of hygiene as ‘those actions and practices that reduce the spread or transmission of pathogenic microorganisms, and thus reduce the incidence of disease’. To examine the implications of this definition, we review the literature related to hand drying as an aspect of hand hygienic practice. Research on hand drying generally focuses on ‘hygienic efficacy’, a concept not typically defined explicitly, but nearly always including alterations to bulk microbial load. The corresponding literature is differentiable into two divisions: research supporting the use of forced air dryers, which typically includes effectiveness of drying as an aspect of hygienic efficacy; and research supporting the use of paper towels, which typically includes risk of aerosolized spread of microbes from hands as an aspect of hygienic efficacy. Utilizing a definition of hygiene that explicitly relies onreduction in disease spreadrather than alterations to bulk microbial load would address concerns raised on both sides of the debate. Future research should take advantage of cultivation-independent techniques, working to bridge the gap between the two existing divisions of research by using health outcomes (such as the spread of disease) as dependent variables, taking into account the microbial community context of the skin microbiota, and focusing on understanding the relative contribution of bioaerosols and residual moisture to the risk of disease transmission.
How to improve parameter estimates in GLM-based fMRI data analysis: cross-validated Bayesian model averaging
Authors: Soch Joram , Meyer Achim Pascal , Haynes John-Dylan , Allefeld Carsten 
Published: December 2016

AbstractIn functional magnetic resonance imaging (fMRI), model quality of general linear models (GLMs) for first-level analysis is rarely assessed. In recent work (Soch et al., 2016: “How to avoid mismodelling in GLM-based fMRI data analysis: cross-validated Bayesian model selection”, NeuroImage, vol. 141, pp. 469-489; DOI: 10.1016/j. neuroimage.2016.07.047), we have introduced cross-validated Bayesian model selection (cvBMS) to infer the best model for a group of subjects and use it to guide second-level analysis. While this is the optimal approach given that the same GLM has to be used for all subjects, there is a much more efficient procedure when model selection only addresses nuisance variables and regressors of interest are included in all candidate models. In this work, we propose cross-validated Bayesian model averaging (cvBMA) to improve parameter estimates for these regressors of interest by combining information from all models using their posterior probabilities. This is particularly useful as different models can lead to different conclusions regarding experimental effects and the most complex model is not necessarily the best choice. We find that cvBMS can prevent not detecting established effects and that cvBMA can be more sensitive to experimental effects than just using even the best model in each subject or the model which is best in a group of subjects.
Deep Multi-instance Networks with Sparse Label Assignment for Whole Mammogram Classification
Authors: Zhu Wentao , Lou Qi , Vang Yeeleng Scott , Xie Xiaohui 
Published: December 2016

AbstractMammogram classification is directly related to computer-aided diagnosis of breast cancer. Traditional methods requires great effort to annotate the training data by costly manual labeling and specialized computational models to detect these annotations during test. Inspired by the success of using deep convolutional features for natural image analysis and multi-instance learning for labeling a set of instances/patches, we propose end-to-end trained deep multiinstance networks for mass classification based on whole mammogram without the aforementioned costly need to annotate the training data. We explore three different schemes to construct deep multi-instance networks for whole mammogram classification. Experimental results on the INbreast dataset demonstrate the robustness of proposed deep networks compared to previous work using segmentation and detection annotations in the training.
Cult of the “I”
Authors: Golub Koraljka , Hansson Joacim , Selden Lars 
Published: December 2016

PurposeThe purpose of the paper is to analyse three Scandinavian iSchools in Denmark, Norway and Sweden with regard to their intentions of becoming iSchools and curriculum content in relation to these intentions. By doing so, a picture will be given of the international expansion of the iSchool concept in terms of organisational symbolism and practical educational content. In order to underline the approaches of the Scandinavian schools, comparisons are made to three American iSchools.Design/methodology/approachThe study is framed through theory on organisational symbolism and the intentions of the iSchool movement as formulated in its vision statements. Empirically, the study consists of two parts: close readings of three documents outlining the considerations of three Scandinavian LIS schools before applying for the iSchool status, and statistical analysis of 427 syllabi from master level courses at three Scandinavian and three American iSchools.FindingsAll three Scandinavian schools, analysed, have recently become iSchools, and though some differences are visible, it is hard to distinguish anything in their syllabi as carriers of what can be described as an iSchool identity. In considering iSchool identity, it instead benefits on a symbolic level that are most prominent, such as branding, social visibility and the possible attraction of new student groups. The traditionally strong relation to national library sectors are emphasised as important to maintain, specifically in Norway and Sweden.Research limitations/implicationsThe study is done on iSchools in Denmark, Norway and Sweden with empirical comparison to three American schools. These comparisons face the challenge of meeting the educational system and programme structure of each individual country. Despite this, findings prove possible to use as ground for conclusions, although empirical generalisations concerning, for instance, other countries must be made with caution.Practical implicationsThis study highlights the practical challenges met in international expansion of the iSchool movement, both on a practical and symbolic level. Both the iSchool Caucus and individual schools considering becoming iSchools may use these findings as a point of reference in development and decision making.Originality/valueThis is an original piece of research from which the results may contribute to the international development of the iSchool movement, and extend the theoretical understanding of the iSchool movement as an educational and organisational construct.
Warrant as a means to study classification system design
Authors: Bullard Julia 
Published: December 2016

Purpose
The purpose of this paper is to examine the role of warrant in daily classification design in general and in negotiating disparate classification goals in particular.

Design/methodology/approach
This paper synthesizes classification research on forms of warrant and uses examples of classification decisions from ethnographic engagement with designers to illustrate how forms of warrant interact in daily classification decisions.

Findings
Different forms of warrant, though associated with incompatible theories of classification design, coexist in daily classification decisions. A secondary warrant might be employed to augment the primary warrant of a system, such as to decide among equally valid terms, or to overturn a decision based on the primary warrant, such as when ethical impacts are prioritized above user preference.

Research limitations/implications
This paper calls for empirical research using the application of warrant as an object of analysis.

Originality/value
The paper connects a ubiquitous and observable element of classification design – the application of warrant – to longstanding divisions in classification theory. This paper demonstrates how the analysis of daily classification design can illuminate the interaction between disparate philosophies of classification.
Genomic and physiological analyses of ‘Reinekea forsetii’ reveal a versatile opportunistic lifestyle during spring algae blooms
Authors: Avcı Burak , Hahnke Richard L. , Chafee Meghan , Fischer Tanja , Gruber‐Vodicka Harald , Tegetmeyer Halina E. , Harder Jens , Fuchs Bernhard M. , Amann Rudolf I. , Teeling Hanno 
Published: December 2016

SummaryGammaproteobacterial Reinekea spp. were detected during North Sea spring algae blooms in the years 2009‐2012, with relative abundances of up to 16% in the bacterioplankton. Here, we explore the ecophysiology of ‘R. forsetii' strain Hel1_31_D35 that was isolated during the 2010 spring bloom using (i) its manually annotated, high‐quality closed genome, (ii) re‐analysis of in situ data from the 2009–2012 blooms and (iii) physiological tests. High resolution analysis of 16S rRNA gene sequences suggested that ‘R. forsetii' dominated Reinekea populations during these blooms. This was corroborated by retrieval of almost complete Hel1_31_D35 genomes from 2009 and 2010 bacterioplankton metagenomes. Strain Hel1_31_D35 can use numerous low‐molecular weight substrates including diverse sugar monomers, and few but relevant algal polysaccharides such as mannan, α‐glucans, and likely bacterial peptidoglycan. It oxidizes thiosulfate to sulfate, and ferments under anoxic conditions. The strain can attach to algae and thrives at low phosphate concentrations as they occur during blooms. Its genome encodes RTX toxin and secretion proteins, and in cultivation experiments Hel1_31_D35 crude cell extracts inhibited growth of a North Sea Polaribacter strain. Our data suggest that the combination of these traits make strain Hel1_31_D35 a versatile opportunist that is particularly competitive during spring phytoplankton blooms.