bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic value of 11C-methionine PET in hyperparathyroidism with negative 99mTc-MIBI SPECT: a meta-analysis
Authors: Yuan Leilei , Liu Jun , Kan Ying , Yang Jigang , Wang Xufu 
Published: September 2016

Background 99mTc-sestamibi (MIBI) parathyroid SPECT is generally regarded as the best preoperative localizing method in patients with hyperparathyroidism (HPT). However, 99mTc-MIBI SPECT is false negative in approximately 25% of adenomas. 11C-methionine positron emission tomography (PET) has been used in HPT with negative 99mTc-MIBI SPECT scan results. Purpose To systematically review and conduct a meta-analysis of published data on the performance of 11C-methionine PET in patients with HPT with negative 99mTc-MIBI SPECT. Material and Methods A comprehensive review of the literature was performed. Pooled sensitivity and specificity of 11C-methionine PET in patients with HPT and a negative 99mTc-MIBI SPECT was calculated on a per-patient basis using receiver-operating characteristic (ROC) methodology. Results Nine studies that met all inclusion and exclusion criteria were included into our meta-analysis, comprising a total sample size of 137 patients. Pooled sensitivity and specificity of 11C-methionine PET in patients with HPT with negative or inconclusive 99mTc-MIBI SPECT scans was 86% and 86%, respectively. The area under the ROC curve was 0.87. Conclusion By merit of the high overall sensitivity, specificity, and accuracy, 11C-methionine PET can potentially complement the diagnostic workup of patients with HPT and negative or inconclusive 99mTc-MIBI SPECT. 11C-methionine PET appears to be a promising diagnostic modality in complicated cases with HPT.
Olanzapine as a possible replacement choice for paliperidone-induced Pisa syndrome: a case report
Authors: Tsou Chang-Chih , Huang San-Yuan 
Published: September 2016

Objective: The aim of this paper is to present a case of paliperidone-induced Pisa syndrome and provide treatment experience. Method: The case report is combined with a review of the literature. Results: A 37-year-old man had been diagnosed with paranoid-type schizophrenia for about 10 years. He received three-month treatment of paliperidone extended release (ER) at 6 mg per day, but showed a progressively Pisa-like physical position. We initially added an anticholinergic drug, but saw no improvement. The paliperidone ER was replaced by olanzapine at 10 mg per day, and the Pisa-like symptom improved after 1 month of the drug replacement. Conclusions: We propose olanzapine as a possible replacement choice for patients with paliperidone-related Pisa syndrome.
Routine treatment duration for clients attending a community based anxiety disorders clinic
Authors: Hannan Anthony , Berle David , Milicevic Denise , Dale Erin , Starcevic Vladan , Brakoulias Vlasios , Viswasam Kirupamani 
Published: September 2016

Objective: To determine the average duration of treatment at a community-based anxiety disorders clinic. Method: Data were collected on primary disorder, the presence of co-occurring disorders and treatment length (both in terms of number of sessions and weeks of therapy) for 248 consecutive clients. Results: The mean number of sessions was 13, and average treatment length was 29 weeks. There was substantial variation in treatment duration (range for number of sessions = 1–128, range for treatment duration = 0–186 weeks). Conclusion: Clients with anxiety disorders were often treated in relatively few sessions, in line with randomised controlled trials (RCTs). However, a number of clients required many more sessions and were treated for a longer period of time than clients in RCTs. Health services should be cautious in mandating limits to therapy duration for anxiety disorders given the wide range in the duration of treatment for clients in our sample.
Proposing a New Debrief Checklist for TeamSTEPPS® to Improve Documentation and Clinical Debriefing
Authors: Clapper Timothy C. 
Published: September 2016

Purpose. The purpose of this article is to propose a new debrief checklist for the Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS®) curriculum. Background. The current debrief checklist provided in the TeamSTEPPS® curriculum focuses on how the team performed, while leaving out the order of events that transpired during the team’s time together. A failure to discuss the order of events can lead to improper or inadequate documentation, which can result in clinical error and increased litigation. Aim. In this article, I explain how the shared mental model, acquired during an actual or simulated clinical event needs to progress to the team debriefing to improve documentation. I propose an improved debrief checklist that is based on practice in numerous healthcare facilities and simulation centers worldwide. Conclusion. The TeamSTEPPS® curriculum should be updated to the new debrief checklist with the shared goal of reducing litigation and billing errors, while increasing patient safety.
Fear of Reinjury in Athletes
Authors: Hsu Chao-Jung , Meierbachtol Adam , George Steven Z. , Chmielewski Terese L. 
Published: September 2016

Context: A sports injury has both physical and psychological consequences for the athlete. A common postinjury psychological response is elevated fear of reinjury. Objective: To provide an overview of the implications of fear of reinjury on the rehabilitation of athletes, including clinical methods to measure fear of reinjury; the impact of fear of reinjury on rehabilitation outcomes, including physical impairments, function, and return to sports rate; and potential interventions to address fear of reinjury during rehabilitation. Evidence Acquisition: PubMed was searched for articles published in the past 16 years (1990-2016) relating to fear of reinjury in athletes. The reference lists of the retrieved articles were searched for additionally relevant articles. Study Design: Clinical review. Level of Evidence: Level 3. Results: Fear of reinjury after a sports injury can negatively affect the recovery of physical impairments, reduce self-report function, and prevent a successful return to sport. Athletes with high fear of reinjury might benefit from a psychologically informed practice approach to improve rehabilitation outcomes. The application of psychologically informed practice would be to measure fear of reinjury in the injured athletes and provide interventions to reduce fear of reinjury to optimize rehabilitation outcomes. Conclusion: Fear of reinjury after a sports injury can lead to poor rehabilitation outcomes. Incorporating principles of psychologically informed practice into sports injury rehabilitation could improve rehabilitation outcomes for athletes with high fear of reinjury.
Morphological diversity of blastula formation and gastrulation in temnopleurid sea urchins
Authors: Kitazawa Chisato , Fujii Tsubasa , Egusa Yuji , Komatsu Miéko , Yamanaka Akira 
Published: September 2016

ABSTRACTEmbryos of temnopleurid sea urchins exhibit species-specific morphologies. While Temnopleurus toreumaticus has a wrinkled blastula and then invaginates continuously at gastrulation, others have a smooth blastula and their invagination is stepwise. We studied blastula and gastrula formation in four temnopleurids using light and scanning electron microscopy to clarify the mechanisms producing these differences. Unlike T. toreumaticus, blastomeres of mid-blastulae in T. reevesii, T. hardwickii and Mespilia globulus formed pseudopods. Before primary mesenchyme cells ingressed, embryos developed an area of orbicular cells in the vegetal plate. The cells surrounding the orbicular cells extended pseudopods toward the orbicular cell area in three Temnopleurus species. In T. toreumaticus, the extracellular matrix was well-developed and developed a hole-like structure that was not formed in others. Gastrulation of T. reevesii, T. hardwickii and M. globulus was stepwise, suggesting that differences of gastrulation are caused by all or some of the following factors: change of cell shape, rearrangement, pushing up and towing of cells. We conclude that (1) many aspects of early morphogenesis differ even among very closely related sea urchins with indirect development and (2) many of these differences may be caused by the cell shape and structure of blastomeres or by differences in extracellular matrix composition.
Polo-like kinase phosphorylation determines Caenorhabditis
elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation
Authors: Wueseke Oliver , Zwicker David , Schwager Anne , Wong Yao Liang , Oegema Karen , Jülicher Frank , Hyman Anthony A. , Woodruff Jeffrey B. 
Published: September 2016

ABSTRACT
Centrosomes are major microtubule-organizing centers composed of centrioles surrounded by an extensive proteinacious layer called the pericentriolar material (PCM). In Caenorhabditiselegans embryos, the mitotic PCM expands by Polo-like kinase 1 (PLK-1) phosphorylation-accelerated assembly of SPD-5 molecules into supramolecular scaffolds. However, how PLK-1 phosphorylation regulates SPD-5 assembly is not known. We found that a mutant version of SPD-5 that is insensitive to PLK-1 phosphorylation (SPD-54A) could localize to PCM but was unable to rescue the reduction in PCM size and density when wild-type SPD-5 levels were decreased. In vitro, purified SPD-54A self-assembled into functional supramolecular scaffolds over long time scales, suggesting that phosphorylation only controls the rate of SPD-5 scaffold assembly. Furthermore, the SPD-5 scaffold, once assembled, remained intact and supported microtubule nucleation in the absence of PLK-1 activity in vivo. We conclude that PLK-1 is required for rapid assembly of the PCM scaffold but not for scaffold maintenance or function. Based on this idea, we developed a theoretical model that adequately predicted PCM growth rates in different mutant conditions in vivo. We propose that PLK-1 phosphorylation-dependent conversion of SPD-5 into an assembly-competent form underlies PCM formation in vivo and that the rate of this conversion determines final PCM size and density.
LINCing the eukaryotic tree of life – towards a broad evolutionary comparison of nucleocytoplasmic bridging complexes
Authors: Meier Iris 
Published: September 2016

ABSTRACT
The nuclear envelope is much more than a simple barrier between nucleoplasm and cytoplasm. Nuclear envelope bridging complexes are protein complexes spanning both the inner and outer nuclear envelope membranes, thus directly connecting the cytoplasm with the nucleoplasm. In metazoans, they are involved in connecting the cytoskeleton with the nucleoskeleton, and act as anchoring platforms at the nuclear envelope for the positioning and moving of both nuclei and chromosomes. Recently, nucleocytoplasmic bridging complexes have also been identified in more evolutionarily diverse organisms, including land plants. Here, I discuss similarities and differences among and between eukaryotic supergroups, specifically of the proteins forming the cytoplasmic surface of these complexes. I am proposing a structure and function for a hypothetical ancestral nucleocytoplasmic bridging complex in the last eukaryotic common ancestor, with the goal to stimulate research in more diverse emerging model organisms.
Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells
Authors: Wang Ying , Cao Ying , Mangalam Ashutosh K. , Guo Yong , LaFrance-Corey Reghann G. , Gamez Jeffrey D. , Atanga Pascal Aliihnui , Clarkson Benjamin D. , Zhang Yuebo , Wang Enfeng , Angom Ramcharan Singh , Dutta Kirthica , Ji Baoan , Pirko Istvan , Lucchinetti Claudia F. , Howe Charles L. , Mukhopadhyay Debabrata 
Published: September 2016

ABSTRACT
Inflammatory response of blood–brain barrier (BBB) endothelial cells plays an important role in pathogenesis of many central nervous system inflammatory diseases, including multiple sclerosis; however, the molecular mechanism mediating BBB endothelial cell inflammatory response remains unclear. In this study, we first observed that knockdown of neuropilin-1 (NRP1), a co-receptor of several structurally diverse ligands, suppressed interferon-γ (IFNγ)-induced C-X-C motif chemokine 10 expression and activation of STAT1 in brain microvascular endothelial cells in a Rac1-dependent manner. Moreover, endothelial-specific NRP1-knockout mice, VECadherin-Cre-ERT2/NRP1flox/flox mice, showed attenuated disease progression during experimental autoimmune encephalomyelitis, a mouse neuroinflammatory disease model. Detailed analysis utilizing histological staining, quantitative PCR, flow cytometry and magnetic resonance imaging demonstrated that deletion of endothelial NRP1 suppressed neuron demyelination, altered lymphocyte infiltration, preserved BBB function and decreased activation of the STAT1–CXCL10 pathway. Furthermore, increased expression of NRP1 was observed in endothelial cells of acute multiple sclerosis lesions. Our data identify a new molecular mechanism of brain microvascular endothelial inflammatory response through NRP1–IFNγ crosstalk that could be a potential target for intervention of endothelial cell dysfunction in neuroinflammatory diseases.
Place of Acquiring and Bankcards in the Sixth Technological Way
Authors: Мартынов  , Martynov V. 
Published: September 2016

The article considers the place and acquiring of Bank plastic cards in the sixth
technological way, this notion of technological way, and periods of cyclical
development of the world economy, their causes and consequences. The
problems of Russia at the entrance to the sixth technological order, including
equiangular segment of the market, the proposal for the modernization of the
banking sector acquiring on the basis of a new technological mode as a key
directions of anti-crisis policy of NFC technology are consecrated. The author
shows the principle of operation of NFC technology.
Polish Adult Reading Test (PART) – construction of Polish test for estimating the level of premorbid intelligence in schizophrenia
Authors: Karakuła-Juchnowicz Hanna , Stecka Mariola 
Published: September 2016

Cel pracyZe względu na niedostępność na rynku polskim standaryzowanych metod do pomiaru PII, celem pracy była konstrukcja polskiego testu do oceny poziomu inteligencji przedchorobowej - PART (Polish Adult Reading Test) oraz ocena jego wartości psychometrycznych, takich jak trafność, rzetelność i standaryzacja w grupie osób chorych na schizofrenię.MetodaZasady tworzenia PART zostały oparte na kanwie popularnego na świecie testu National Adult Reading Test autorstwa N. Hazel. Badania objęły grupę 122 osób w wieku od 18 do 60 r.ż., w skład, której weszła grupa 65 osób chorych na schizofrenię i 57 osób zdrowych psychicznie dobranych pod względem wieku i płci.WynikiPART okazał się testem o wysokiej spójności wewnętrznej oraz rzetelności mierzonej procedurami: test-retest i zgodności ocen dwóch niezależnych badających (inter-rater reliability), a także o akceptowalnej trafności diagnostycznej i prognostycznej. Opracowano także procedury standaryzacyjne PART.WnioskiBiorąc pod uwagę własności psychometryczne PART oraz krótki czas jego wykonania, test ten może stanowić użyteczne narzędzie diagnostyczne w ocenie przedchorobowego poziomu inteligencji w grupie pacjentów ze schizofrenią.
Sandwich ELISA Using a Mouse/Human Chimeric CSLEX-1 Antibody
Authors: Yamashita J , Kobayashi I , Tatematsu K , Sezutsu H , Noda K , Ishihara H 
Published: September 2016

AbstractBACKGROUNDAn assay using a mouse antisialyl Lewis X (sLeX) antibody (CSLEX-1) is used clinically for screening and monitoring patients with breast cancer in Japan. However, the IgM isoform of CSLEX-1 is not preferred for the assay because the bulkiness of IgM generally causes poor accessibility to the antigen. To solve this problem, we developed an antisLeX mouse/human chimeric IgG antibody, CH-CSLEX-1, using transgenic silkworms. The performance of a homologous sandwich ELISA of CH-CSLEX1 was then evaluated.METHODSTo generate CH-CSLEX-1, we used a GAL4/UAS binary gene expression system in transgenic silkworms. The reactivities of CSLEX-1 and CH-CSLEX-1 were determined in a Biacore analysis. To confirm antigen specificity, 3 antigens [sLeX, sLeA, and Lewis Y (LeY)] were used.RESULTSCH-CSLEX-1 formed correctly as an IgG class of immunoglobulin molecule with an isoelectric point close to the predicted value. The best combination for capturing and probing in a sandwich ELISA was determined as a homologous combination of CH-CSLEX-1. The CH-CSLEX-1 assay specifically detected sLeX, but not sLeA and LeY. A correlation analysis with 107 human samples showed good concordance between the conventional CSLEX-1 assay (homologous sandwich ELISA using CSLEX-1) and the CH-CSLEX-1 assay (r = 0.98). Moreover, the CH-CSLEX-1 assay was not affected by either human antimouse IgG antibodies (HAMA IgG) or HAMA IgM.CONCLUSIONSThe mouse/human chimeric antibody CH-CSLEX-1 allowed the establishment of a highly specific sandwich ELISA for sLeX that was not affected by HAMA.
A Novel Potassium-Competitive Acid Blocker Improves the Efficacy of Clarithromycin-containing 7-day Triple Therapy against Helicobacter pylori
Authors: Noda Hisatsugu , Noguchi Seiji , Yoshimine Takashi , Goji Shigeki , Adachi Kazunori , Tamura Yasuhiro , Izawa Shinya , Ebi Masahide , Yamamoto Sayuri , Ogasawara Naotaka , Funaki Yasushi , Sasaki Makoto , Kasugai Kunio 
Published: September 2016

Background & Aims: In Japan, 7-day triple therapy for Helicobacter pylori including clarithromycin (CAM) was approved in 2000. However, antibiotic resistance subsequently reduced this rate to an unacceptable level (70%). Vonoprazan, an orally bioavailable potassium-competitive acid blocker (P-CAB), was approved in Japan in 2014. This could improve eradication rates by increasing the intragastric pH, thus increasing bacterial antibiotic susceptibility. This study compared the efficacy of 7-day triple therapies that included CAM and vonoprazan or proton pump inhibitor (PPI).
Methods: We prospectively analyzed H. pylori eradication rates in 146 patients receiving 7-day triple therapy containing P-CAB (April 2015 to September 2015), and in a retrospective cohort of 1,305 patients who received 7-day triple therapy containing a PPI (April 2011 to September 2015).
Results: H. pylori was eradicated in a significantly higher number of P-CAB-treated patients (89.7% [131/146]) than PPI-treated patients (73.9% [965/1305]; p < 0.05). The eradication rates in P-CAB-treated CAM-sensitive and CAM-resistant bacteria were 100% (44/44) and 87.5% (28/32), respectively, which were significantly higher than the corresponding rates in PPI-treated patients (88.0% [22/25] and 53.8% [7/13], p < 0.05).Conclusion: P-CAB improved the efficacy of CAM-containing 7-day triple therapy and would be a valuable first-line treatment for H. pylori infection.
Key words: – – – .
Abbreviations: CAM: clarithromycin; CAM-R: clarithromycin- resistant; CAM-S: clarithromycin-sensitive; OR: odds ratio; P-CAB: potassium-competitive acid blocker; PPI: proton pump inhibitor.
Superiority of a Split-dose Regimen of Sodium Picosulfate/ Magnesium Citrate (SPMC) in Comparison to a Prior-day Schedule (AM/PM) for Colonoscopy Preparation. A Randomized Single-blinded Study
Authors: Schulz Christian , Müller Joachim , Sauter Joachim , Miehlke Stephan , Schmöcker Christoph , Hartmann Dirk , Malfertheiner Peter , Badiola Carlos 
Published: September 2016

Background & Aims: Split-dose regimens are generally recommended for bowel cleansers. However, other regimens still remain in the summary of product characteristics of some bowel cleansers in Europe. The aim of this study is to compare the efficacy and safety of a split-dose regimen of sodium picosulfate/magnesium citrate (SPMC) with a prior-day schedule (AM/PM).
Methods: Multicenter, randomized (EudraCT no. 2013-001620-20), endoscopist-blinded, parallel study, carried out in subjects 18 years or older undergoing elective colonoscopy. The primary endpoint was the bowel cleansing assessment using a binary transformation (adequate/inadequate) of the Global Preparation Assessment (GPA) scale. Additional parameters analyzed were the segmental assessment of bowel cleansing (RSS), the adenoma detection rate and safety evaluations.
Results: 315 subjects comprised the ITT set. A significantly higher proportion of patients in the split-dose regimen had an adequate bowel preparation (AM/PM: 30.8% vs split-dose: 79.9%; p<0.0001). The mean global RSS was significantly lower in the split-dose group (AM/PM: 5.0 [SD: 2.91] vs split-dose: 2.6 [SD: 2.14]; p<0.0001). Flat polyps were detected in a higher proportion of subjects in the split-dose group compared with the AM/PM group (AM/PM: 16.0% vs split-dose: 22.0%). Both regimens were equally safe and well tolerated, with no serious treatment-emergent adverse events or discontinuations due to adverse events.
Conclusion: A split-dose regimen of SPMC is superior to the AM/PM regimen administered the day before colonoscopy. Split regimen of SPMC should be considered the standard of use.
Abbreviations: CTCAE: Common Terminology Criteria for Adverse Events; eGFR: Glomerular filtration rate; mITT: modified intent-to-treat; RSS: Residual Stool Score; SA: safety analysis; SAE: serious adverse event; SmPC: summary of product characteristics; SPMC: sodium picosulfate-magnesium citrate.
Thyroid papillary carcinoma presenting with femoral neck metastasis: a case report
Authors: Aktas Birol , Uygur Mehmet Esat , Soylemez Mehmet Salih , Kemah Bahattin , Bilgic Bilge , Ceyran Bahar , Ozkan Korhan 
Published: September 2016

<p>Thyroid carcinoma is relatively uncommon, accounting for 2% of all cancers. Although they usually present as a neck lump, occasionally they may be presented with a distant metastasis. In this study, a 65 year-old woman was referred to our clinic with a pain on her left hip at both rest and walking. A lytic area at the inferior femoral neck was found with plain radiography. To clarify the characteristics of the lesion, left hip magnetic resonance imaging (MRI) had been performed displaying 3×5 cm hyperintense lesion extending from medial part of the left femoral neck to the left femoral head. Laboratory findings were normal. An open biopsy had then been performed from the left femoral neck with a suspicion of a metastatic tumor. After Immunohistochemical assesment diagnosis was consistent with metastatic thyroid papillary cancer. Proximal femoral resection with clear margins were achieved by proximal femur tumor endoprosthesis. In conclusion, papillary thyroid cancer have an excellent prognosis and doesn’t tend to metastese. But rarely, as seen in our case it can even present with syptoms of metastasic disease. Management strategy is the same as other solitary bone metastasis. Papillary thyroid cancer must be kept in mind as a differential diagnosis in solitary bone metatasis.</p>
Editorial
Authors: Mayorga Witton Becerra 
Published: September 2016

de difundir los resultados de investigaciones en el campo general de la literatura. En esta tarea, hemos avanzado en la indexación de nuestra revista en algunas bases de datos que pretenden darle más visibilidad a los trabajos que aquí publicamos. Sin embargo, ese sabor agridulce de esta labor se hace más evidente cuando comprobamos que definitivamente estamos abocados a un mundo en el que la forma interesa más que el contenido. En la última evaluación de nuestra revista por parte de Publindex no pudimos obtener la categoría B por un artículo; debíamos haber publicado al año 11 artículos de los tipos 1, 2 y 3 y en el resultado final de la evaluación quedamos con 10 porque algunos no correspondían a esta tipología, según la evaluación.