bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities
Authors: Kafle Alok , Suttiprapa Sutas , Muhammad Mubarak , Tenorio Jan Clyden B. , Mahato Roshan Kumar , Sahimin Norhidayu , Loong Shih Keng 
Published: September 2024

Background
Epigenetic modifications, such as DNA methylation and histone modifications, are pivotal in regulating gene expression pathways related to inflammation and cancer. While there is substantial research on epigenetic markers in cholangiocarcinoma (CCA), Opisthorchis viverrini-induced cholangiocarcinoma (Ov-CCA) is overlooked as a neglected tropical disease (NTD) with limited representation in the literature. Considering the distinct etiological agent, pathogenic mechanisms, and pathological manifestations, epigenetic research plays a pivotal role in uncovering markers and potential targets related to the cancer-promoting and morbidity-inducing liver fluke parasite prevalent in the Great Mekong Subregion (GMS). Emerging studies highlight a predominant hypermethylation phenotype in Opisthorchis viverrini (O. viverrini) tumor tissues, underscoring the significance of abnormal DNA methylation and histone modifications in genes and their promoters as reliable targets for Ov-CCA.

Principal findings
Relevant published literature was identified by searching major electronic databases using targeted search queries. This process retrieved a total of 81 peer-reviewed research articles deemed eligible for inclusion, as they partially or fully met the pre-defined selection criteria. These eligible articles underwent a qualitative synthesis and were included in the scoping review. Within these, 11 studies specifically explored Ov-CCA tissues to investigate potential epigenetic biomarkers and therapeutic targets. This subset of 11 articles provided a foundation for exploring the applications of epigenetics-based therapies and biomarkers for Ov-CCA. These articles delved into various epigenetic modifications, including DNA methylation and histone modifications, and examined genes with aberrant epigenetic changes linked to deregulated signalling pathways in Ov-CCA progression.

Conclusions
This review identified epigenetic changes and Wnt/β-catenin pathway deregulation as key drivers in Ov-CCA pathogenesis. Promoter hypermethylation of specific genes suggests potential diagnostic biomarkers and dysregulation of Wnt/β-catenin-modulating genes contributes to pathway activation in Ov-CCA progression. Reversible epigenetic changes offer opportunities for dynamic disease monitoring and targeted interventions. Therefore, this study underscores the importance of these epigenetic modifications in Ov-CCA development, suggesting novel therapeutic targets within disrupted signalling networks. However, additional validation is crucial for translating these novel insights into clinically applicable strategies, enhancing personalised Ov-CCA management approaches.
Determinants of care-seeking behavior for sexually transmitted infections among sexually active men in East Africa: A multilevel mixed effect analysis
Authors: Seifu Beminate Lemma , Fente Bezawit Melak , Melkam Mamaru , Asmare Zufan Alamrie , Asnake Angwach Abrham , Bezie Meklit Melaku , Asebe Hiwot Altaye , Negussie Yohannes Mekuria 
Published: September 2024

Background
Addressing the global challenge of sexually transmitted infections (STIs) is crucial and demands immediate attention. Raising awareness, improving healthcare facilities, and implementing preventive measures are necessary to reduce the spread and mitigate their adverse effects. The treatment seeking behavior of individuals in relation to STIs is an important factor in STI prevention and control. Thus, this study aimed to identify factors associated with STI-related care-seeking behavior among sexually active men in East Africa.

Methods
A weighted sample of 3,302 sexually active men from recent Demographic and Health Surveys (DHSs) in East African countries were included for analysis. To accommodate the inherent clustering in DHS data and the binary nature of the dependent variable, we applied a multi-level mixed-effect logistic regression model. The deviance value was used to select the best-fitted model. The strength of the association was estimated using an adjusted odds ratio, along with a 95% confidence interval, and statistical significance was determined at a p-value < 0.05.

Result
The pooled prevalence of STI-related care-seeking behavior among sexually active men in East Africa was 71% (95%CI: 69.76, 72.75). In the multivariable multilevel model, individuals in the age groups of 25–34 (AOR = 1.58, 95%CI: 1.22, 2.04) and 44 years and above (AOR = 1.44, 95%CI: 1.01, 2.02), those who were married (AOR = 1.62, 95%CI: 1.25, 2.11), had 1 (AOR = 1.88, 95%CI: 1.50, 2.35) and ≥2 (AOR = 2.53, 95%CI: 1.89, 3.39) sexual partners excluding their spouse, had ever been tested for HIV (AOR = 1.86, 95%CI: 1.52, 2.28), and had media exposure (AOR = 1.30, 95%CI: 1.04, 1.62) had a positive association with care-seeking behavior for STIs.

Conclusion
Based on our findings, seven out of ten sexually active men in East Africa exhibit care-seeking behavior for STIs. It is crucial to implement policies and strategies aimed at improving the health-seeking habits of young, unmarried men. Utilizing diverse media platforms to disseminate accurate information and success stories about STI symptoms is pivotal in achieving this goal.
Patent Clearinghouse and Technology Diffusion: What is the Contribution of Arbitration Agreements?
Authors: Bacchiega Emanuele , Bonroy Olivier , Hervouet Adrien 
Published: September 2024

Abstract
One of the acknowledged advantages of patent clearinghouses is that they favor the diffusion of technology. In traditional clearinghouses, patents are usually bundled in pools and sold at a pre-set price. Recently, in the biotechnology industry a new form of clearinghouse has been observed, where patent tariffs are instead bargained over by the clearinghouse members. Exchange is then guaranteed by arbitration agreements to which the negotiating parties are bound, should their bargaining reach a dead end. This paper assesses the effect on technology diffusion of this new type of clearinghouse. We show that such arbitration agreements, through their effect on the outside options, may reduce the incentives of a member of the clearinghouse to license to non-members. This result highlights the role of such arbitration agreements in the diffusion of technology outside the clearinghouse.
Robbery, Restitution, and Remembrance in Germany
Authors: Duma Veronika 
Published: September 2024

Abstract
The essay draws a panorama of the current state of the Holocaust compensation and provenance research in Germany. It discusses the German politic of “Wiedergutmachung”, the recent cases of restitution, the public debate about commemoration and the challenges when it comes to restituting objects robbed 80 years ago. On the one hand, Germany – especially with regards to restitution measures up to the 1960s – is used as a role model in the international discourse on restitution issues. On the other hand, there is also a history of critique accompanying the German “Widergutmachungspolitik”. The essay argues that future research should analytically separate the different levels of the history of compensation: the official German discourse and wording of commemoration politics, the history of actual payments, the research and remembrance done by institutions like universities or memorials, and the initiatives of survivor organizations and civil society. They follow their own agendas and often are contradictory.
Nonlinear finite-element analysis of RC beams with various opening near supports
Authors: Ali M. Taher Hawra Mohamed 
Published: September 2024

Abstract
The structural integrity of a reinforced concrete (RC) beam could be compromised by the need for web holes for utilities like air conditioning and electricity. In places with high shear loads, these voids may appear near the columns supporting the structure. The impact of web openings close to the supports on the behavior of RC beams is inspected numerically in this article. Four-point loads were applied to the supports of seven RC beams with holes of varied sizes and locations. The crack patterns and deflections of the seven beams were analyzed in comparison to those of a solid RC beam without an aperture. The goal of the experiment was to verify that all simulation procedures were accurate and complete. The numerical analysis results showed that the experimentally tested failure load was in excellent consent with the numerical results. Therefore, the finite-element approach is a particularly reliable technique for exploring the nonlinear behavior of beams with multiple apertures, both from the perspectives of difficulty and time savings. Analytical and code equations were used to compare the measured load–deflection magnitude and shear strength of the examined RC beams to their prophesied values. The test findings demonstrated that the shear load capacity of RC beams was reduced by as much as 24.9% as compared to a solid beam, as shown by testing results. The shear load capacity for small-size openings was less than the solid beam by 12.8, 21.1, and 21.6%, while for the biggest openings by 34.6, 29.5, and 34.2% when taking the distance from the support 0, 100, and 200 mm.
Good Art as a Civilizing Enterprise: Collingwood Against Mass Corruption of Consciousness
Authors: Collins David 
Published: September 2024

Abstract
It is surprising that the connections between Collingwood’s aesthetics and his political philosophy have been little explored, considering the distinctly social focus of the final chapter of The Principles of Art (1938) and the political motivation behind Collingwood’s worries about the “corruption of consciousness,” to which he sees art as a potential remedy. This essay explores this connection, arguing for a strong parallel between this idea of the corruption of consciousness and what Collingwood, in The New Leviathan (1942), calls “barbarism.” I argue that bringing out this parallel helps shed light on the central importance that Collingwood saw art having for civilization itself.
Psychological aspects of infertility
Authors: Wischmann Tewes 
Published: September 2024

Summary
The unfulfilled desire for children is a significant problem worldwide. The psychological effects of this development are usually underestimated, while the myth of “psychogenic infertility” stubbornly persists. This article first provides an overview of the basic facts on the subject before highlighting the psychological effects of both the diagnosis of infertility and the therapeutic options. Psychological aspects of “third-party” reproduction and further developments after childbirth or without a child are discussed, followed by a brief outline of the general and specific subject matter addressed in infertility counselling. The article concludes with reflections on the possible psychological consequences of further medical developments in this area.
Neural network-assisted meta-router for fiber mode and polarization demultiplexing
Authors: Zhao Yu , Wang Huijiao , Huang Tian , Guan Zhiqiang , Li Zile , Yu Lei , Yu Shaohua , Zheng Guoxing 
Published: September 2024

Abstract
Advancements in computer science have propelled society into an era of data explosion, marked by a critical need for enhanced data transmission capacity, particularly in the realm of space-division multiplexing and demultiplexing devices for fiber communications. However, recently developed mode demultiplexers primarily focus on mode divisions within one dimension rather than multiple dimensions (i.e., intensity distributions and polarization states), which significantly limits their applicability in space-division multiplexing communications. In this context, we introduce a neural network-assisted meta-router to recognize intensity distributions and polarization states of optical fiber modes, achieved through a single layer of metasurface optimized via neural network techniques. Specifically, a four-mode meta-router is theoretically designed and experimentally characterized, which enables four modes, comprising two spatial modes with two polarization states, independently divided into distinct spatial regions, and successfully recognized by positions of corresponding spatial regions. Our framework provides a paradigm for fiber mode demultiplexing apparatus characterized by application compatibility, transmission capacity, and function scalability with ultra-simple design and ultra-compact device. Merging metasurfaces, neural network and mode routing, this proposed framework paves a practical pathway towards intelligent metasurface-aided optical interconnection, including applications such as fiber communication, object recognition and classification, as well as information display, processing, and encryption.
High-efficiency and broadband asymmetric spin–orbit interaction based on high-order composite phase modulation
Authors: Ou Yuzhong , Chen Yan , Zhang Fei , Pu Mingbo , Jiang Mengna , Xu Mingfeng , Guo Yinghui , Feng Chaolong , Gao Ping , Luo Xiangang 
Published: September 2024

Abstract
Asymmetric spin–orbit interaction (ASOI) breaks the limitations in conjugate symmetry of traditional geometric phase metasurfaces, bringing new opportunities for various applications such as spin-decoupled holography, imaging, and complex light field manipulation. Since anisotropy is a requirement for spin–orbit interactions, existing ASOI mainly relies on meta-atom with C1 and C2 symmetries, which usually suffer from an efficiency decrease caused by the propagation phase control through the structural size. Here, we demonstrate for the first time that ASOI can be realized in meta-atoms with rotational symmetry ≥3 by combining the generalized geometric phase with the propagation phase. Utilizing an all-metallic configuration, the average diffraction efficiency of the spin-decoupled beam deflector based on C3 meta-atoms reaches ∼84 % in the wavelength range of 9.3–10.6 μm, which is much higher than that of the commonly used C2 meta-atoms with the same period and height. This is because the anisotropy of the C3 metasurface originates from the lattice coupling effect, which is relatively insensitive to the propagation phase control through the meta-atom size. A spin-decoupled beam deflector and hologram meta-device were experimentally demonstrated and performed well over a broadband wavelength range. This work opens a new route for ASOI, which is significant for realizing high-efficiency and broadband spin-decoupled meta-devices.
Crystal structure of (R)(R)-5-chloro-3-((S,1E,3E)-3,5-dimethyl-hepta-1,3-dien-1-yl)-7-methyl-6,8-dioxo-2,6,7,8-tetrahydroisoquinolin-7-yl acetate, C21H24ClNO4
Authors: Bi Shu-Feng , Li Hong-Lei , Li Fei-Fei , Chen Xiang-Yang 
Published: September 2024

Abstract
C21H24CINO4, monoclinic, P21 (no. 14), a = 8.6813(3) Å, b = 7.3821(2) Å, c = 16.0325(6) Å, β = 105.282(2)°, V = 991.13(6) Å3, Z = 2, R
gt(F) = 0.0405, wR
ref(F
2) = 0.1014, T = 296.15 K.
The crystal structure of (E)-(2-(2-hydroxy-3-methoxybenzylidene)aminophenyl)arsonic acid, C14H14AsNO5
Authors: Cai Bin , Ke Jia-Bo , Wu Cen-Cen , An Yi-Bo , Qiao Yu , Li Shuo 
Published: September 2024

Abstract
C14H14AsNO5, monoclinic, P21 (no. 4), a = 8.5830(5) Å, b = 7.0799(5) Å, c = 11.6011(7) Å, β = 100.059(2)∘, V = 694.13(8) Å3, Z = 2, R
gt(F) = 0.0288, wR
ref(F
2) = 0.0603, T = 150.0 K.
Minor millets: Processing techniques and their nutritional and health benefits
Authors: Kang Puneet , Karumanthra Krishnanand Anagha , Kaur Sawinder , Rasane Prasad , Singh Jyoti , Nanda Vikas , Assouguem Amine , Lahlali Rachid , Ullah Riaz , Alqahtani Ali S. 
Published: September 2024

Abstract
In recent years, there has been a surge in the popularity of minor millets, also called ancient grains. As a result, there has been a growing interest in the potential health benefits and unique dietary properties that these foods offer. Once considered a forgotten crop, millet has gained popularity as part of efforts to achieve sustainable development goals. With a growing population, there is a need to explore sustainable methods to provide food and nutritional security to people, and millets offer a promising solution to this objective. This literature review aims to provide a thorough and all-encompassing overview of the geographical distribution of minor millets, as well as the challenges and opportunities associated with their production. Additionally, this review will investigate the nutritional benefits of minor millets and their potential for use in the development of value-added products.
The Mason-Alberta Phonetic Segmenter: a forced alignment system based on deep neural networks and interpolation
Authors: Kelley Matthew C. , Perry Scott James , Tucker Benjamin V. 
Published: September 2024

Abstract
Given an orthographic transcription, forced alignment systems automatically determine boundaries between segments in speech, facilitating the use of large corpora. In the present paper, we introduce a neural network-based forced alignment system, the Mason-Alberta Phonetic Segmenter (MAPS). MAPS serves as a testbed for two possible improvements we pursue for forced alignment systems. The first is treating the acoustic model as a tagger, rather than a classifier, motivated by the common understanding that segments are not truly discrete and often overlap. The second is an interpolation technique to allow more precise boundaries than the typical 10 ms limit in modern systems. During testing, all system configurations we trained significantly outperformed the state-of-the-art Montreal Forced Aligner in the 10 ms boundary placement tolerance threshold. The greatest difference achieved was a 28.13 % relative performance increase. The Montreal Forced Aligner began to slightly outperform our models at around a 30 ms tolerance. We also reflect on the training process for acoustic modeling in forced alignment, highlighting how the output targets for these models do not match phoneticians’ conception of similarity between phones and that reconciling this tension may require rethinking the task and output targets or how speech itself should be segmented.
Impact of laparoscopic ultrasound during PIPAC directed treatment of unresectable peritoneal metastasis
Authors: Jørgensen Magnus S. , Ainsworth Alan P. , Fristrup Claus W. , Mortensen Michael B. , Graversen Martin 
Published: September 2024

Abstract

Objectives
Laparoscopic ultrasound (LUS) combines both laparoscopy and ultrasound imaging of the peritoneum liver and retroperitoneum. LUS has not been described in treatments with pressurized intraperitoneal aerosol chemotherapy (PIPAC). We present our experience with LUS in patients undergoing PIPAC.

Methods
Retrospective study of LUS findings from the prospective PIPAC-OPC2 trial. Main outcome was changes in overall treatment strategy due to LUS findings.

Results
PIPAC-OPC2 included 143 patients of which 33 patients were treated with electrostatic precipitation PIPAC. Nine patients were excluded due to primary non-access. During PIPAC 1, LUS was performed in 112 of 134 (84 %) PIPAC procedures and changed overall treatment strategy in one patient due to detection of multiple liver metastases unseen by baseline CT. During PIPAC 2 and 3 LUS was performed in 59 of 104 (57 %) and 42 of 78 (54 %) PIPAC procedures, respectively. Throughout PIPAC 1–3, LUS also detected pathological lymph nodes in 16 patients, and focal liver lesions in another four patients of uncertain origin. No further examinations were performed in these patients, and the overall treatment strategy was not changed according to the PIPAC-OPC2 protocol. One patient had a splenic capsule rupture related to the LUS itself. This was managed conservatively.

Conclusions
LUS may be safely performed during PIPAC. However, LUS has limited clinical impact in patients scheduled for PIPAC, and cannot be recommended as a routine procedure when performing PIPAC.
Le suplico me ynbíe un rretrato chiquito suyo para que le pueda traer conmigo. La emperatriz María Ana de Austria (1606–1646) y el uso de los retratos en la corte imperial de Viena
Authors: Standhartinger Christian , Sommer-Mathis Andrea 
Published: September 2024

Este artículo examina el uso del retrato en la corte imperial de Viena durante la primera mitad del siglo XVII. Partiendo de las largas negociaciones nupciales sobre el matrimonio de la infanta española María (Ana) con el archiduque y más tarde emperador Fernando III, se analiza el retrato como elemento central de la política matrimonial en las cortes europeas, que a menudo intercambiaban cuadros y miniaturas de los candidatos a casarse para disponer de información fidedigna por lo menos sobre su aspecto físico. Sin embargo, los retratos también desempeñaron un papel importante en el ámbito familiar de las casas soberanas. La correspondencia de María con su marido Fernando ofrece varios ejemplos de cómo los retratos no sólo servían para salvar la distancia geográfica y hacer presente simbólicamente a la persona ausente, sino también para ofrecer consuelo y apoyo moral durante el tiempo de separación.
KARAKTERISTIK MUTU PENGOLAHAN RAJUNGAN (Portunnus pelagicus) PASTEURISASI DALAM KALENG DI PT. NCM, MAKASSAR
Authors: Sipahutar Yuliati H. , Wiran La Ode Ibnu , Siregar Arpan Nasri , Sirait Jaulim 
Published: September 2024

Pengalengan adalah metode pengawetan makanan dengan cara memanaskannya dalam suhu yang dapat membunuh mikroorganisme, dan kemudian menutupnya dalam kaleng. Penelitian bertujuan untuk dengan mengetahui proses pengolahan rajungan pasteurisasi dalam kaleng. Metode dilakukan dengan observasi dan survei, dengan meninjau secara cermat langsung di lokasi pengolahan, mulai dari bahan baku masuk, proses pengolahan hingga pemuatan. Pengujian mutu bahan baku daging rajungan rebus dingin dan daging rajungan pasteurisasi dalam kaleng meliputi mutu sensori, mikrobiologi (Angka Lempeng Total/ALT. Escherichia coli dan salmonella) dan kimia (chloramphenicol). Analisa data dilakukan dengan deskriptif. Hasil penelitian menunjukkan bahwa alur proses pengolahan ranjungan terdiri dari 12 tahapan yaitu receiving, sortasi, metal detecting, mixing, filling & weighing, seaming, Pasteurisasi, chilling, packing , chillstorage, stuffing. Hasil uji nilai sensori daging rajungan rebus dingin rata-rata 7.16, dan sensori rajungan kaleng pasteurisasi nilai rata-rata 8.59. Hasil uji mikrobiologi daging rajungan rebus dingin ALT berkisar 3x101-1,3x102 kol/gram, E.coli < 3 dan Salmonella negative, chloramphenicol 0,012. Hasil uji mikrobiologi daging rajungan pasteurisasi dalam kaleng berkisar 3x101-1,3x102 kol/gram, E.coli < 3 dan Salmonella negative. Hasil uji kimia daging rajungan rebus dingin rata-rata kadar air 70%,chloramphenicol 0,012 ppb dan rajungan kaleng pasteurisasi nilai rata-rata kadar air 70% dan chloramphenicol 0,11 ppb