bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symbiodiniaceae diversity in Pocillopora corals in different environments of the Colombian Eastern Pacific: symbiont specificity in spite of coral-host flexibility
Authors: Millán-Márquez Ana M. , Velasco-Montoya Dana A. , Terraneo Tullia I. , Benzoni Francesca , Bocanegra-Castaño Carolina , Zapata Fernando A. 
Published: September 2024

AbstractReef-building corals live in close mutualism with dinoflagellate algae (family Symbiodiniaceae), which play key roles in coral physiological performance and survival. Association patterns between host species and endosymbiont algae and their significance are still not fully understood, but they seem to affect the ability of hosts to inhabit different environments and their resilience to climate change. In this work, we used next-generation sequencing of the Internal Transcribed Spacer 2 region of ribosomal DNA to determine the diversity and composition of the Symbiodiniaceae community in Pocillopora corals from Colombia, in the Eastern Tropical Pacific (ETP). We sampled 243 colonies from four localities characterized by distinct sea surface temperature, turbidity, and proximity to the coast. Two genera of Symbiodiniaceae, Durusdinium and Cladocopium were found associated with Pocillopora mitochondrial Open Reading Frame (mtORF) types. Cladocopium latusorum was highly specific to Pocillopora mtORF type 1, while C. pacificum was found exclusively associated with Pocillopora mtORF type 3. In contrast, Durusdinium glynnii was found in both Pocillopora mtORF types. Furthermore, a Cladocopium-dominated symbiont community occurred in cooler and less turbid localities, while a Durusdinium- dominated community was found in localities with high sea surface temperature and high water turbidity, irrespective of mtORF type. These results suggest that Pocillopora mtORF lineages associate with different Symbiodiniaceae genera in response to local environmental conditions. The ability to associate with a different partner under particular environmental conditions (Pocillopora-Durusdinium combination), and also maintain a specific partnership (Cladocopium species and Pocillopora mtORF types) may be key to understanding the resilience of the genus Pocillopora on ETP coral reefs.
Prognostic value of ABO blood groups in upfront operated pancreatic ductal adenocarcinomas
Authors: Joliat Gaëtan-Romain , Labgaa Ismail , Martin David , Vrochides Dionisios , Schäfer Markus 
Published: September 2024

Abstract
Purpose
Pancreatic ductal adenocarcinoma (PDAC) has been shown to have a lower incidence in patients with blood group O. It is currently uncertain if patients with group O have a better prognosis after pancreatectomy. This study assessed the overall survival (OS) and disease-free survival (DFS) of PDAC patients who underwent upfront pancreatoduodenectomy based on ABO blood groups.

Methods
A cross-sectional study was performed including patients from two university centers. All consecutive head PDAC patients who underwent upfront pancreatoduodenectomy from 2000 to 2016 were included. OS and DFS were compared between blood groups A, B, AB, and O using Kaplan-Meier curves and log-rank tests.

Results
A total of 438 patients were included (215 women, median age 67). Pre- and intraoperative details were comparable between all subgroups. Median OS did not differ between the four blood groups (A: 23 months, 95% CI 18–28; B: 32, 95% CI 20–44; AB: 37, 95% CI 18–56 and O: 26, 95% CI 20–32, p = 0.192). Median DFS were also similar (A: 19 months, 95% CI 15–23; B: 26, 95% CI 19–33; AB: 35, 95% CI 15–55 and O: 22, 95% CI 15–29, p = 0.441). There was no OS difference between O and non-O groups (median: 26 months, 95% CI 20–33 vs. 25 months, 95% CI 20–30, p = 0.773). On multivariable analysis blood groups were not prognostic of OS. Only lymph node involvement, tumor differentiation, and adjuvant chemotherapy were independent prognostic factors.

Conclusion
OS and DFS were similar between all four blood groups after pancreatoduodenectomy. Independent predictors of OS were associated with tumor characteristics and adjuvant treatment.
A physics-informed kernel approach to learning the operator for parametric PDEs
Authors: Kurz J. , Bowman B. , Seman M. , Oian C. , Khan T. 
Published: September 2024

AbstractOperator networks are neural networks designed to learn operators with special emphasis on solution operators for parameterized families of partial differential equations (PDEs). Once trained, operator networks can provide a solution to a PDE more quickly than current numerical PDE solvers by several orders of magnitude. Fourier neural operators (FNOs) and deep operator networks (DeepONets) are the two primary operator networks in existence for learning the solution operator to PDEs and have mostly only been applied to two-dimensional or three-dimensional problems, due to the computational expense of training networks in higher dimensional settings. The sole exception is a model-parallel FNO, which decomposes the function input domain space. We demonstrate a neural operator network with a physics-informed integral kernel that, once trained, is able to predict skin and ocular media’s time-dependent thermal response to incident laser radiation much more rapidly than existing numerical algorithms.
Complication rates after autologous cranioplasty following decompressive craniectomy
Authors: Ritter Leonard , Strohhäcker Kilian , Schebesch Karl-Michael , Eibl Thomas , Höhne Julius , Liebert Adrian 
Published: September 2024

Abstract

Objective
The reimplantation of autologous bone grafts after decompressive craniectomy (DC) is still up for debate. The objective of this study was to analyze the surgical revision rate for autologous cranioplasties in our center, aiming to identify predictors for procedure-related-complications.

Methods
A retrospective single-center study was conducted for adult patients who underwent autologous cranioplasty after DC. The primary endpoint was the complication rate in terms of surgical revision and removal of the bone graft: infection, new onset seizures, dislocation, haemorrhage, osteolysis, wound dehiscence and cerebrospinal fluid (CSF) fistula. Demographic data, medical records, surgical reports and imaging studies were analysed and risk factors for complications were evaluated.

Results
169 consecutive patients were included. The median interval between DC and cranioplasty was 84 days. Mean age was 51 ± 12.4 years. 26 patients (15.3%) had revision surgery for following reasons. n = 9 implant dislocations (5.3%), n = 7 osteolysis (3.6%), n = 6 infections (3.6%), n = 5 had re-bleedings (3%), n = 5 wound dehiscences (3%), and n = 2 CSF fistulas (1.2%). 18 patients developed new seizures (10.7%). Bi- and multivariate analysis revealed three independent risk factors, simultaneous ventriculo-peritoneal (VP) shunting increased the risk for material dislocation (p < 0.001); large bone grafts (> 193.5 cm2) increased the risk for osteolysis (p = 0.001) and bifrontal cranioplasties were associated with higher risk for infections (p = 0.04).

Conclusion
The complication rates in our study were comparable to previously reported data for autologous or artificial cranioplasties. As osteolysis was correlated to larger bone grafts, a synthetic alternative should be considered in selected cases.
Evaluation of risk factors associated with the peritoneal flap hernioplasty for complex incisional hernia repair - a retrospective review of 327 cases
Authors: Nielsen Kristian Als , Tulloh Bruce , de Beaux Andrew , Pedersen Andreas Kristian , Petersen Sofie Ronja , Jogvansson Brandur , Ellebaek Mark Bremholm , Valsamidis Alexandros , Alnabhan Ayat Allah , Helligsø Per , Nielsen Michael Festersen 
Published: September 2024

Abstract
Background
Repair of large incisional hernias is challenging, and the risks of postoperative complications have been associated with obesity, smoking, and diabetes. The present study was conducted to determine the impact of these risk factors on short and long-term outcomes following the repair with the peritoneal flap hernioplasty (PFH).

Methods
Three hundred twenty-seven patients undergoing PFH for incisional hernia repair were identified. Patient demographics and clinical data were recorded. Patients presenting signs of complications were assessed during a visit to the outpatient clinic. A multivariable regression analysis was performed to evaluate the association between BMI, smoking and diabetes, and postoperative complications.

Results
The study included 157 males (48.0%) and 170 females (52.0%). Median BMI was 30.9 kg/m2. Diabetes was present in 13.8% of patients. 23.2% were active smokers. The recurrence rate was 2.4%. The odds ratios for postoperative complications were increased by 9% per BMI unit (P < 0.01), due predominantly to a rise in superficial wound infections (P < 0.01) and seroma production (P = 0.07). The adjusted odds ratio increased fourfold in patients with BMI > 40 kg/m2 (P = 0.06).

Conclusion
Incisional hernia repair with the PFH technique is associated with a low risk of short and long-term complications. The risk is associated with obesity and significantly increased in patients with a BMI exceeding 40 kg/m2, where a fourfold increase was observed predominantly due to seroma and superficial wound infections. The recurrence rate was 2.4% and was unaltered across BMI categories. No association was established between smoking, diabetes, and the risk of all-cause complications.
Exploring the power of data-driven models for groundwater system conceptualization: a case study of the Grazer Feld Aquifer, Austria
Authors: Kokimova Ainur , Collenteur Raoul A. , Birk Steffen 
Published: September 2024

AbstractDeveloping a reliable conceptual model is crucial for analyzing groundwater systems. An essential part of the aquifer conceptualization is the identification of the hydrological stresses that control the hydraulic head fluctuations. By effectively capturing and understanding these stresses, the propagation of potential errors and uncertainties through subsequent modeling steps can be minimized. This study aims to test data-driven models as screening models for conceptualizing a groundwater system. The case study is applied to the Grazer Feld Aquifer in southeast Austria. Time series models are applied to: (1) identify the stresses likely influencing the observed head fluctuations and their spatial variability; (2) identify locations where a lack of understanding of head fluctuations exists; and (3) discuss the limitations and opportunities associated with data-driven models to support system conceptualization. Time series models were created for 144 monitoring wells where sufficient head observations were available during the calibration period (2005–2015). A total of 576 models were developed, incorporating the combinations of stresses: recharge, river level, and a step trend. Following the model selection process, each model was categorized based on its performance and divided into four groups. At 88 sites, recharge and river level variations were identified as the primary controlling stresses influencing head fluctuations. The inclusion of the step trend was found to be necessary at five sites to accurately simulate heads due to dam construction. The application of data-driven models in this study enhanced the identification of key aquifer stresses, facilitating a more informed understanding of the groundwater system.
An axiomatization of the Shapley mapping using strong monotonicity in interval games
Authors: Ishihara Shinichi , Shino Junnosuke 
Published: September 2024

Abstract
Interval games are an extension of cooperative coalitional games in which players are assumed to face payoff uncertainty. Characteristic functions thus assign a closed interval instead of a real number. In this paper, we focus on interval game versions of Shapley values. First, we modify Young’s strong monotonicity axiom for coalitional games into two versions so that they can be applied to the Shapley mapping and show that this can be axiomatized within the entire class of interval games using either version. Second, we derive the Shapley mapping for specific examples by employing two approaches used in the proof of the axiomatization and argue that our approach effectively works for a wide range of interval games.
Molecular screening of piroplasms and Anaplasmataceae agents in Hyalomma dromedarii ticks from camels over different seasons in Egypt
Authors: Elsawy Bassma S. M. , Abdel-Ghany Hoda S. M. , Alzan Heba F. , Abdel-Shafy Sobhy , Shahein Yasser E. 
Published: September 2024

AbstractPiroplasmosis, a disease of domestic and wild animals, is caused by tick-borne protozoa of the genera Babesia and Theileria, while anaplasmosis is caused by tick-borne bacteria of genera Anaplasma. Hyalomma dromedarii is the most dominant tick species infesting camels in Egypt and act as a vector of piroplasms, Anaplasma, Rickettsia and Ehrlichia spp. The available information concerning the detection of these pathogens in H. dromedarii infesting camels is limited. The present study aimed to evaluate the status of these pathogens in H. dromedarii ticks over four seasons of a year, in addition to investigate the infections of piroplasms and Anaplasmataceae besides their genetic diversity starting from June 2021 till April 2022. A total of 275 semi-engorged females of H. dromedarii were collected from different slaughtered camels, Toukh city slaughterhouse then investigated by Polymerase Chain Reaction (PCR) to detect piroplasms (Babesia spp., Theileria spp.) and Anaplasmataceae DNA targeting 18 S rRNA and 16 S rRNA genes, respectively followed by sequencing and phylogenetic analyses. Overall, piroplasms were detected in 38 ticks (13.8%), Babesia spp. was detected in 35 ticks (12.7%), while Theileria spp. was detected in one tick (0.4%). Anaplasmataceae was detected in 57 ticks (20.7%). Mixed infections of piroplasms and Anaplasmataceae were detected in 13 ticks (5%). Single infection either with piroplasms or Anaplasmataceae was detected in 25 (9%) and 44 (16%) ticks, respectively. The highest monthly rate of piroplasms was in April (spring) and Anaplasmataceae was in July (summer). Sequence analysis revealed that Babesia bigemina, Wolbachia spp. and Anaplasma marginale are the most dominant species in the examined tick samples. To the best of our knowledge, this study confirms the presence of B. bigemina, Wolbachia spp. and A. marginale in H. dromedarii in Egypt by sequencing.
ZIP8 A391T Crohn’s Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation
Authors: Yang Julianne C. , Zhao Matthew , Chernikova Diana , Arias-Jayo Nerea , Zhou Yi , Situ Jamilla , Gutta Arjun , Chang Candace , Liang Fengting , Lagishetty Venu , Jacobs Jonathan P. 
Published: September 2024

Abstract
Background
The pathogenesis of Crohn’s disease involves genetic and environmental factors, with the gut microbiome playing a crucial role. The Crohn’s disease-associated variant rs13107325 in the SLC39A8 gene results in an A391T substitution in the ZIP8 metal ion transporter and has previously been linked to alterations in the colonic microbiome in variant carriers. We hypothesized that the A391T substitution alters metal ion homeostasis in the colonic mucosal–luminal interface, thereby inducing dysbiosis which may promote intestinal inflammation.

Methods
To evaluate this hypothesis, we generated a SLC39A8 A393T mouse model (matching human A391T). We first examined trace element abundance in the colonic mucosal epithelium and lumen of homozygous A393T and wild-type (WT) mice to determine if the variant affected metal distribution. We also performed 16S rRNA gene sequencing on colon samples at 2 months, 3–4 months, and 12 months of age, and conducted histological scoring of colon tissue collected from 5-month and 10-month old mice.

Results
Consistent with an effect of the variant on ZIP8 function, homozygous A393T mice exhibited increased cobalt in the colonic mucosa, but reduced iron, zinc, manganese, cobalt, copper, and cadmium in the colonic lumen. 16S rRNA gene sequencing of colon samples revealed variant-linked effects on microbiome beta diversity in 2-month-, 3–4-month-, and 12-month-old mice. Histological scoring showed spontaneous intestinal inflammation in 10-month but not in 5-month-old mice. Lastly, predicted pathway analysis of the microbiome samples revealed differential enrichment of iron-, zinc-, and cobalt-dependent pathways in A393T mice compared to wild-type controls.

Conclusion
These results suggest that the variant in SLC39A8 primarily restricts metal availability to the microbiota, resulting in compositions that can adapt to the environment and that A393T-linked dysbiosis occurs prior to the onset of inflammation. This study paves the way for future studies investigating risk variants as microbiome-disease modifiers.

Graphical Abstract
Ruraling career guidance research and practice: learning from rural perspectives
Authors: Alexander Rosie , Fuqua Melyssa 
Published: September 2024

AbstractExisting career guidance research and practice is based on urban, or metrocentric, models and assumptions, which are problematic for rural communities. In the field of education, researchers have argued that ‘ruraling’ scholarship can be beneficial in challenging existing metrocentric models and opening new ways of imagining practice. In this paper, we apply the concept of ‘ruraling’ to the field of career guidance, arguing that rural scholarship can reveal implicit spatial assumptions in existing models and approaches, challenge neoliberal and metrocentric discourses and re-envision career guidance in ways that are more inclusive and spatially sensitive.
Corneal densitometry measurements comparison between anterior segment OCT and scheimpflug imaging
Authors: Lupardi Enrico , Moramarco Antonio , Cassini Federico , Febbraro Simone , Savini Giacomo , Fontana Luigi 
Published: September 2024

Abstract
Purpose
To evaluate and compare the repeatability of corneal densitometry (CD) measurements obtained using both an anterior-segment optical coherence tomography (AS-OCT) device and a Scheimpflug camera system, while also assessing the level of agreement. The study also sought to investigate the correlation of CD with age, gender, and central corneal thickness (CCT) in normal eyes.

Methods
CD measurements were obtained using the Casia 2 and the Pentacam AXL Wave. Data were collected on Total Corneal Densitometry and 4 concentric corneal annular areas, these are referred to as zone 1, denoting the central area, through to zone 4, designating the outermost peripheral region. Repeatability was assessed using intra-session test–retest variability, coefficient of variation (CoV), and intraclass correlation coefficient (ICC). The agreement was evaluated using Bland–Altman plots. Correlation analysis was performed between CD, age, gender, and CCT.

Results
The study included 96 healthy volunteers. The Casia 2 demonstrated high repeatability with ICC values exceeding 0.9 in all the corneal zones and lower CoV values compared to the Pentacam AXL Wave (ranging from 1.07% to 2.25% for Casia 2 and from 1.91% to 6.89% for Pentacam).95% LoA were within ± 2 standard deviation from the average mean except from zone 1 (± 2.42).However, the measurements showed a consistent bias among all the corneal zones. CD values were positively correlated with age, except for zone 1 with the Pentacam (p = 0.083).

Conclusions
The findings suggest that the Casia 2 can be a reliable tool for assessing corneal transparency in healthy individuals, however its measurements are not interchangeable with those provided by the Pentacam. The AS-OCT device may be more sensitive in detecting subtle age-related changes in CD within the central zone.
A novel strategy to produce spherical SBA-15 by polymeric macrospheres as a template for drug delivery
Authors: Jaime-Escalante Betzabeth , Rolón-Ávalos Alejandro , Melgoza-Contreras Luz María , Leyva-Gómez Gerardo , Emparan-Legaspi María José , Mendoza-Muñoz Néstor 
Published: September 2024

Abstract
Mesoporous silica SBA-15 has been a material widely studied for drug delivery due to its high biocompatibility and chemical stability, its ordered mesoporous cavities allow drug loading. However, it has a non-spherical particle shape, making it difficult to use in solid dosage forms, where spherical particles are preferred for better flow and distribution. In this regard, this study presented a novel strategy to produce spheric SBA-15 using polymeric macrospheres of a pharmaceutical grade acidic-resistant copolymer (Eudragit®S) stabilized with Pluronic® 123, as a template. The macrospheres of Eudragit®S were fabricated using the double emulsion (W1/O/W2) solvent-diffusion technique and then were used as a template to synthesize macrospheres of SBA-15 following acidic hydrolysis. The physicochemical analysis revealed that the SBA-15 has a spherical morphology (SEM) with pores arranged in a hexagonal lattice (TEM). The XRD showed signals at 0.71, 0.88 y 2.03 °2θ, that were indexed at the Miller indices (100), (110), (200). Nitrogen adsorption-desorption isotherms (type IV, H3) demonstrated mesoporous characteristics with a pore size of 9.3 nm, a wall thickness of 3 nm, a pore volume of 0.7538 cm³g−1, and a surface area of 640 m²g−1. These SBA-15 macrospheres also showed a zero-order release of ibuprofen. The SBA-15 formation using Eudragit®S macrospheres suggests that P123 on the macrosphere acts as a spherical core, as shown by FT-IR analysis. The acid-resistant copolymer maintained macrosphere integrity, enabling the assembly of the SBA-15 mesostructure in a 24-hour manufacturing time under acidic conditions.
Determination of rare earth elements in ferrocarbonatite using ICP-AES and ICP-MS
Authors: Thangavel S. , Venkateswarlu G. , Durgaprasad A. , Sunilkumar Beena , Khuntia A. , Dash K. , Durani S. 
Published: September 2024

AbstractA method has been developed for the determination of Rare Earth Elements (REEs) in ferrocarbonatite using Inductively Coupled Plasma—Atomic Emission Spectrometer (ICP-AES) and Inductively Coupled Plasma—Mass Spectrometer (ICP-MS). The conventional dissolution procedures are tedious, with large measurement uncertainty and are thus not suitable for certified reference material (CRM) production and exploration of REEs. The described method involves leaching of sample using 3 M HCl followed by dissolution of residue (silica and REEs) by HF then determined REEs using ICP-AES and ICP-MS. The leaching step prevents formation of fluoride precipitates of matrix (Ca, Mg, Ba and Al). The method has been validated using CRMs.