bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometrial pattern predicts pregnancy outcome in single‐blastocyst frozen‐embryo transfer: An analysis of 1383 cycles
Authors: Kuramoto Kazutaka , Hamada Norio , Kawamura Keiko , Egashira Katsuko , Morokuma Seiichi , Otsuka Misako , Yoshioka Naomi , Kuramoto Takeshi , Kato Kiyoko 
Published: September 2024

AbstractPurposeSeveral studies investigated endometrial patterns, with respect to pregnancy rates following the transfer of embryos but did not distinguish between single‐ and multiple‐blastocyst procedures. We clarified how the endometrial pattern imaged to transfer a frozen embryo is associated with pregnancy outcomes in single‐blastocyst frozen‐embryo transfer (sbFET).MethodsPatients ≤35 years who underwent sbFET on the hormone replacement protocol. We analyzed endometrial patterns’ associations with pregnancy outcomes in relation to blastocyst grade and pregnancy‐related factors.ResultsOf the 1383 cycles, 483 were Lf, 840 were partial‐Lf, and 60 were non‐Lf. Leaf pattern (Lf): central echogenic line present and continuous. Overall, decreasing distinctness of the central echogenic line was associated with significantly lower rates of clinical pregnancy (Lf: 70.4%; partial‐Lf: 58.1%; non‐Lf: 28.3%) and live birth (56.3%, 45.5%, and 15.0%) and a higher miscarriage rate (20.0%, 21.7%, and 47.1%). Logistic regressions showed pregnancy and live birth to be significantly more likely and miscarriage less likely in Lf than non‐Lf: OR (95% CI): 6.07 (3.24–11.37), 7.43 (3.47–15.39), and 0.20 (0.07–0.57).ConclusionsNon‐Lf presentation was associated with lower rates of pregnancy and live birth, suggesting it signals unsuitable conditions for embryo transfer. We provide information on the pregnancy outcomes of sbFET for endometrial patterns.
Bioactive Nb2C MXene‐Functionalized Hydrogel with Microenvironment Remodeling and Enhanced Neurogenesis to Promote Skeletal Muscle Regeneration and Functional Restoration
Authors: Zheng Hua , Yang Zuoting , Zhou Li , Zhang Baoliang , Cheng Ruidong , Zhang Qiuyu 
Published: September 2024

AbstractThe complete structure‐functional repair of volumetric muscle loss (VML) remains a giant challenge and biomedical hydrogels to remodel microenvironment and enhance neurogenesis have appeared to be a promising direction. However, the current hydrogels for VML repair hardly achieve these two goals simultaneously due to their insufficient functionality and the challenge in high‐cost of bioactive factors. In this study, a facile strategy using Nb2C MXene‐functionalized hydrogel (OPTN) as a bioactive scaffold is proposed to promote VML repair with skeletal muscle regeneration and functional restoration. In vitro experiments show that OPTN scaffold can effectively scavenge reactive oxygen species (ROS), guide macrophages polarization toward M2 phenotype, and resist bacterial infection, providing a favorable microenvironment for myoblasts proliferation as well as the endothelial cells proliferation, migration, and tube formation. More importantly, OPTN scaffold with electroactive feature remarkably boosts myoblasts differentiation and mesenchymal stem cells neural differentiation. Animal experiments further confirm that OPTN scaffold can achieve a prominent structure‐functional VML repair by attenuating ROS levels, alleviating inflammation, reducing fibrosis, and facilitating angiogenesis, newborn myotube formation, and neurogenesis. Collectively, this study provides a highly promising and effective strategy for the structure‐functional VML repair through designing bioactive multifunctional hydrogel with microenvironment remodeling and enhanced neurogenesis.
Soft and Deformable Thermoresponsive Hollow Rod‐Shaped Microgels
Authors: Hagemans Fabian , Hazra Nabanita , Lovasz Viktoria D. , Awad Alexander J. , Frenken Martin , Babenyshev Andrey , Laukkanen Olli‐Ville , Braunmiller Dominik , Richtering Walter , Crassous Jérôme J. 
Published: September 2024

AbstractDepending on their aspect ratio, rod‐shaped particles exhibit a much richer 2D and 3D phase behavior than their spherical counterparts, with additional nematic and smectic phases accompanied by defined orientational ordering. While the phase diagram of colloidal hard rods is extensively explored, little is known about the influence of softness in such systems, partly due to the absence of appropriate model systems. Additionally, investigating higher volume fractions for long rods is usually complicated because non‐equilibrium dynamical arrest is likely to precede the formation of more defined states. This has motivated us to develop micrometric rod‐like microgels with limited sedimentation that can respond to temperature and reversibly reorganize into defined phases via annealing and seeding procedures. A detailed procedure is presented for synthesizing rod‐shaped hollow poly(N‐isopropylacrylamide) microgels using micrometric silica rods as sacrificial templates. Their morphological characterization is conducted through a combination of microscopy and light scattering techniques, evidencing the unconstrained swelling of rod‐shaped hollow microgels compared to core‐shell microgel rods. Different aspects of their assembly in dispersion and at interfaces are further tested to illustrate the opportunities and challenges offered by such systems that combine softness, anisotropy, and thermoresponsivity.
Anti‐Frosting and Defrosting Fins with Hierarchical Interlocking Structure for Enhancing Energy Utilization Efficiency of Heat Exchanger
Authors: Zhao Yue , Liu Wenzhuo , Du Yu , Tong Jun , Xie Heng , Wu Ting , Qu Jinping 
Published: September 2024

AbstractAir conditioners, being an indispensable component of contemporary living, consume a significant amount of electricity every year. The accumulation of frost, dust, and water on the fins surface hinders the efficiency of the heat exchange process, thereby reducing the effectiveness of the air conditioning system. To address these limitations, this paper proposes a large‐scale and cost‐effective method combining compression molding, chemical etching, and spray coating to fabricate aluminum fins (HMNA) with hierarchical interlocking structures. The HMNA exhibits outstanding durability, passive and active anti‐icing, anti‐frosting and defrosting, and self‐cleaning capabilities associated with the robust super‐hydrophobicity. The hierarchical interlocking structure effectively enhances the physical and environmental durability of the HMNA. Most significantly, the frost time of the HMNA fins assembled heat exchanger is significantly delayed by ≈700% compared to the traditional Al fins heat exchanger, while the frost layer thickness is reduced by ≈75%. This greatly reduces the frequency with which the defrosting cycle is started, thus effectively improving the efficiency of the air conditioning system. The proposed method for economical and mass production of the HMNA fins can be an excellent candidate for the development of low energy consumption air conditioning system.
Proving Functional Program Equivalence via Directed Lemma Synthesis
Authors: Sun Yican , Ji Ruyi , Fang Jian , Jiang Xuanlin , Chen Mingshuai , Xiong Yingfei 
Published: September 2024

AbstractProving equivalence between functional programs is a fundamental problem in program verification, which often amounts to reasoning about algebraic data types (ADTs) and compositions of structural recursions. Modern theorem provers provide structural induction for such reasoning, but a structural induction on the original theorem is often insufficient for many equivalence theorems. In such cases, one has to invent a set of lemmas, prove these lemmas by additional induction, and use these lemmas to prove the original theorem. There is, however, a lack of systematic understanding of what lemmas are needed for inductive proofs and how these lemmas can be synthesized automatically. This paper presents directed lemma synthesis, an effective approach to automating equivalence proofs by discovering critical lemmas using program synthesis techniques. We first identify two induction-friendly forms of propositions that give formal guarantees to the progress of the proof. We then propose two tactics that synthesize and apply lemmas, thereby transforming the proof goal into induction-friendly forms. Both tactics reduce lemma synthesis to a set of independent and typically small program synthesis problems that can be efficiently solved. Experimental results demonstrate the effectiveness of our approach: Compared to state-of-the-art equivalence checkers employing heuristic-based lemma enumeration, directed lemma synthesis saves 95.47% runtime on average and solves 38 more tasks over an extended version of the standard benchmark set.
Classification methods of pulmonary contusion based on chest CT and the association with in-hospital outcomes: a systematic review of literature
Authors: Van Diepen Max R. , Wijffels Mathieu M. E. , Verhofstad Michael H. J. , Van Lieshout Esther M. M. 
Published: September 2024

Abstract
Introduction
Patients sustaining pulmonary contusion (PC) have a higher risk of complications and long-term respiratory difficulty. Computed tomography (CT) scans have a high sensitivity for PC. However, since PC develops over time, CT scans made directly post-trauma may underestimate the full extent of PC. This creates a need to better define in which PC-patients complications are more likely. The aim of this systematic review was to identify different classification systems of PC, and investigate the association between amount of PC and in-hospital outcomes.

Methods
A systematic review was conducted in accordance with PRISMA guidelines. Studies reporting a classification system for PC after blunt thoracic trauma based on a CT scan were included. Outcomes were classification method of PC and the relation between classification and pulmonary complications and in-hospital outcomes.

Results
Twenty studies were included. Total number of patients ranged from 49 to 148,140 patients. The most common classification system used was calculating the percentage of contused lung volume. Other classification methods were based on Blunt Pulmonary Contusion score-6 and -18, Abbreviated Injury Score and Thoracic Trauma Severity scores. Worse outcomes were generally associated with between > 18 to > 24% contusion volume.

Discussion
The heterogeneity of currently available literature makes comparing classification methods challenging. The most common classification of PC was based on volumetric analysis. Calculating a percentage of PC as part of the total volume allows for the highest level of segmentation of lung parenchyma as compared to using BPC-6, BPC-18, or AIS. Contusion volume exceeding 18–24% was generally associated with worse outcomes.
Gerechtigkeit und soziale Determinanten der Gesundheit im Lebenslauf
Authors: Kolland Franz , Rohner Rebekka 
Published: September 2024

Zusammenfassung
Hintergrund
Der soziostrukturelle und soziokulturelle Wandel in den westlichen Gesellschaften stellt die Gesundheitseinrichtungen zunehmend vor Herausforderungen, die Gesundheit und Würde der Menschen gut zu berücksichtigen. Weitere und nachhaltige Fortschritte in der Gesundheitsversorgung sind zunehmend von soziokulturellen Bedingungen beeinflusst. Werden diese Bedingungen unzureichend berücksichtigt, sind die weiteren medizinischen Fortschritte gefährdet.

Ziel der Arbeit
Das Ziel dieser Arbeit liegt darin, die Bedeutung sozialer Bedingungen der Gesundheit im Lebenslauf herauszuarbeiten und damit eines der vier ethischen Prinzipien in der Medizin, nämlich die Gerechtigkeit, genauer auszuleuchten.

Material und Methoden
Bearbeitet wird die Fragestellung anhand sozialwissenschaftlicher Literatur, wobei die Literatur unter strukturtheoretischer Perspektive gesichtet wurde.

Ergebnisse
Fühlen sich Menschen in Hinsicht auf Alter, Geschlecht oder Migrationshintergrund diskriminiert, dann hat das nicht nur Auswirkungen auf das Selbstwertgefühl, sondern auch auf die Gesundheit bzw. Rekonvaleszenz nach Erkrankungen. Ungünstige wirtschaftliche Lebensverhältnisse wirken sich auf das Gesundheitsverhalten negativ aus. Diskriminierungserfahrungen im Gesundheitswesen können die Zufriedenheit mit Behandlungen verringern und dazu beitragen, dass Behandlungsvorschriften nicht eingehalten werden.

Schlussfolgerung
Beeinflusst werden können die angeführten soziokulturellen Effekte nicht nur über individuelle Verhaltensänderungen, sondern insbesondere auch über strukturelle bzw. institutionelle Wandlungsprozesse. Es braucht eine „Habitussensibilität“ sowohl im klinischen als auch im niedergelassenen Bereich, das heißt, die Verantwortung von Ärzt*innen im Gesundheitssystem liegt auch in der Beseitigung von Diskriminierung.
EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease
Authors: Finke Daniel , Hund Hauke , Frey Norbert , Luft Thomas , Lehmann Lorenz H. 
Published: September 2024

Abstract
Background
Coronary interventions reduce morbidity and mortality in patients with acute coronary syndrome. However, the risk of mortality for patients with coronary artery disease (CAD) additionally depends on their systemic endothelial health status. The ‘Endothelial Activation and Stress Index’ (EASIX) predicts endothelial complications and survival in diverse clinical settings.

Objective
We hypothesized that EASIX may predict mortality in patients with CAD.

Methods
In 1283 patients undergoing coronary catheterization (CC) and having a diagnosis of CAD, EASIX was measured within 52 days (range − 1 year to − 14 days) before CC and correlated with overall survival. In an independent validation cohort of 1934 patients, EASIXval was measured within 174 days (+ 28 days to + 11 years) after CC.

Results
EASIX predicted the risk of mortality after CC (per log2: hazard ratio (HR) 1.29, 95% confidence interval: [1.18–1.41], p < 0.001) in multivariable Cox regression analyses adjusting for age, sex, a high-grade coronary stenosis ≥ 90%, left ventricular ejection fraction, arterial hypertension and diabetes. In the independent cohort, EASIX correlated with EASIXval with rho = 0.7. The long-term predictive value of EASIXval was confirmed (per log2: HR 1.53, [1.42–1.64], p < 0.001) and could be validated by integrated Brier score and concordance index. Pre-established cut-offs (0.88–2.32) associated with increased mortality (cut-off 0.88: HR training: 1.63; HR validation: 1.67, p < 0.0001 and cut-off 2.32: HR training: 3.57; HR validation: 4.65, p < 0.0001).

Conclusions
We validated EASIX as a potential biomarker to predict death of CAD patients, irrespective of the timing either before or after catheterization.

Graphical abstract
Allometric equations for biomass and carbon pool estimation in short rotation Pinus radiata stands of the Western Cape, South Africa
Authors: Pienaar Louis Otto , Calama Rafael , Olivar Jorge , Wellstein Camilla , Pretzsch Hans , du Toit Ben 
Published: September 2024

AbstractThe quantification of tree growth and carbon storage over time is an important task for sustainable forest management and carbon sequestration projects. For the South African short-rotation Pinus radiata (D. Don) forests, this knowledge is lacking. We developed allometric equations and compared the estimated weights to previously published biomass studies and we used Dirichlet Regression (DR) modelling to ensure additivity of the component proportions. The biomass components and their contribution to carbon storage depend strongly on forest structure and mean tree size but also on-site conditions and tree architecture. Our first two hypotheses were that the (1) best model for stemwood (SW), bark and total mass will include the combined variable DBH2H and (2) that the DR will yield statistically similar estimates for all components when compared to the best models. Our third hypothesis was that allometric equations developed for sites with high resource availability (e.g. wet, fertile sites) will yield biased estimates when extrapolated to sites with lower levels of resource availability (drier and/or infertile sites). The results indicated that DBH2H was the best variable to describe SW, bark and total mass and the DR yield similar estimates for all component proportions when compared to the best models. There were strong similarities in the SW and total mass of independent test sites in comparison to the SW and total mass of this study but greater variability in the bark, needle and branch mass. This can be associated to site and seasonal differences as well as variability in tree architecture brought about by different silvicultural operations on individual sites. Previously developed equations by other authors for sites with high resource availability overpredicted the SW and total mass of the models developed in this study. Our set of additive component equations performed well even when applied to sites of similar productivity over a climate gradient. The presented new equations bridge the gap in knowledge where allometric equations for short rotation Radiata pine stands are lacking.
Building meaningful collaboration in conservation genetics and genomics
Authors: Shaw Robyn E. , Brockett Brittany , Pierson Jennifer C. , Sarre Stephen D. , Doyle Paula , Cliff Hannah B. , Eldridge Mark D. B. , Miller Kimberly A. , Ottewell Kym , Parrott Marissa L. , Rossetto Maurizio , Sunnucks Paul , Banks Sam C. , Byrne Margaret , Campbell Bridget L. , Chong Caroline , Ens Emilie J. , Ferraro Paul A. , Grueber Catherine E. , Harrison Peter A. , Hogg Carolyn , Hutton Marlee , Roycroft Emily , Sowersby Will , Karajarri Rangers  , Kiwirrkurra Rangers  , Ngurrara Rangers  , Nyangumarta Rangers  , Ngururrpa Rangers  , Neaves Linda E. 
Published: September 2024

AbstractGenetic diversity is the foundation of biodiversity, and preserving it is therefore fundamental to conservation practice. However, global conservation efforts face significant challenges integrating genetic and genomic approaches into applied management and policy. As collaborative partnerships are increasingly recognized as key components of successful conservation efforts, we explore their role and relevance in the Australian context, by engaging with key entities from across the conservation sector, including academia, botanic gardens, herbaria, seed banks, governmental/non-governmental organisations, private industry, museums, Traditional Owners, Indigenous rangers, and zoos and aquaria. By combining perspectives from these entities with comprehensive literature review, we identified five guiding principles for conservation genetic and genomic research and explored the different elements of, and approaches to, collaboration. Our reflections suggest that there is a substantial overlap in research interests across the Australian conservation sector, and our findings show that collaboration is increasing. We discuss approaches to building collaborative partnerships, the reciprocal benefits of collaborating, and some remaining challenges associated with data generation, data collection, and cross-cultural considerations. We emphasise the need for long-term national resourcing for sample and data storage and consistency in collecting, generating and reporting genetic data. While informed by the Australian experience, our goal is to support researchers and practitioners to foster meaningful collaborations that achieve measurable management outcomes in conservation genetics and genomics, both in Australia and globally.
Uncertainty and Fertility in Ukraine on the Eve of Russia’s Full-Scale Invasion: The Impact of Armed Conflict and Economic Crisis
Authors: Perelli-Harris Brienna , Gerber Theodore , Hilevych Yuliya 
Published: September 2024

Abstract
While uncertainty has been a key explanation for very low fertility throughout Europe, few studies have analysed how macro-level uncertainty trickles down to shape how people think about having children. Most research focuses on economic uncertainty, not political or social uncertainty. We address these gaps with qualitative data from Ukraine, which has experienced extreme political uncertainty and, for the past decade, armed conflict. Ukraine also had exceptionally low fertility, with an estimated total fertility rate of 1.17 in 2021. In July 2021, we conducted 16 online focus groups on topics related to childbearing with informants living in urban and rural areas in Eastern Ukraine, including areas of Donetsk province that were outside Ukrainian government control. Half the groups consisted of persons displaced by the 2014 Donbas war. The discussions revealed distinct patterns whereby experiences of displacement, the simmering armed conflict, and economic problems combined to produce and intensify uncertainties that discouraged couples from having more than one child. Some blamed the government or delved into conspiracy theories. Armed conflict generates its own forms of uncertainty that interact with persistent economic challenges, dampening fertility.
Exploring perceptions of public good(s), government, and global contributions in Japanese higher education: a phenomenographic approach
Authors: Huang Futao , Chen Lilan , Horiuchi Kiyomi 
Published: September 2024

Abstract
This study explores the multifaceted concept of “public good(s)” in the context of Japanese higher education. Through interviews with 11 stakeholders, including policymakers, representatives from academic associations, and institutional leaders from two national universities, the research reveals that “public good(s)” are perceived as societal benefits transcending individual interests, emphasizing inclusivity and open access. It underscores higher education and research’s diverse roles in fostering “public good(s)” by cultivating enlightened citizens, generating knowledge, and promoting collaboration. The study highlights the evolving government-higher education relationship in Japan, transitioning from traditional intervention to strategic planning and policy guidance while maintaining a delicate balance between financial support and institutional autonomy. Personal backgrounds and identities shape stakeholders’ interpretations and recommendations, contributing to the nuanced understanding of “public good(s)” in Japan’s higher education landscape. The research also draws comparisons with global trends, emphasizing Japan’s distinctive reliance on government funding, STEM focus, and commitment to global contributions rooted in cultural values. Ultimately, this study provides valuable insights into the complex dynamics of government-higher education relationships and the concept of “public good(s)” in Japanese higher education.
Religiosity and Health Outcomes in a Cohort of Romanian Patients Hospitalized for COVID-19
Authors: Frent Stefan , Popovici Alexandru-Filip , Balan Adrian , Cerbu Bianca , Marincu Iosif , Mihaicuta Stefan , Bikov Andras 
Published: September 2024

Abstract
There is a growing body of evidence for the interrelation between health status and religious beliefs. Our aim was to evaluate the level of religiosity in patients hospitalized for COVID-19 and to assess the link between religiosity and measurable health outcomes. This was an observational, single-center study which included patients with moderate-to-severe forms of COVID-19. A total of 112 patients were enrolled in the study, of whom 77 were highly religious (CRS-15 score ≥ 4) and 35 non-highly religious (CRS-15 score < 4). There was no difference in demographics or prevalence of comorbidities between the two groups. Furthermore, we found no difference between groups in radiological extension of lung lesions, length of hospital stays, or ICU need; however, in-hospital mortality rate was significantly lower in highly religious group (1% vs. 14%, p = 0.005). Serum ferritin level at admission was significantly lower (p = 0.03) and prevalence of post-COVID-19 pulmonary sequelae significantly higher in highly religious group (p = 0.02).