bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis for selection of best methodology in determining the lean enabled supply chain agility: An AHP &amp; fuzzy SWARA-WASPAS based approach
Authors: Sharma Hemant , Sohani Nagendra 
Published: September 2024

Abstract

Almost all the manufacturing organizations today needs such a supply chain network which is efficient as well as responsive to optimize their lead time by quick supply along with cheap cost. This could be done either by the adoption of lean strategy which focuses on efficient supply chain enhancement, or the adoption of agile strategy, the primary objective of which is to enhance responsive supply chain. But as seen in most of the manufacturing organizations, their range of products are meant for different categories of customers which starts from low cost to high cost. As per the market study the positioning of the product highly depends upon the differentiation of the customers which leads to the best strategy as per the leaverage of both lean & agility. So adoption of either of the strategy alone is not the best idea to fulfill their objective, while the adoption of a combination of both strategy partially could fulfil their requirement, the concept is termed as leagile supply chain. In this paper the authors has investigated & identified 28 lean enablers, 11 agile factors which are highly responsible to affect any supply chain specially focusing of automobile sector. Apart from above 9 leagile enablers were also identified in the paper. After that few methodologies among many of the Multi-criteria decision making (MCDM) are adopted to find the ranking as well as some interrelationships among the identified enablers or factors. The innovation in the paper is that the authors has proposed the fuzzy SWARA-WASPAS based approach for determining the role of lean in enabling the supply chain agility. Also in continuation the AHP methodology is applied to find the priority weightage & ranking of leagile enablers.Finally the comparative analysis has been done in the results obtained by both the applied strategies to have a more clear picture for the stakeholders, whether to adopt any of them as per the customized requirement of their supply chain.
Improving thermostability of salt-tolerant xylanase from Hortaea werneckii EXF-12619 by N-terminal replacement and C-terminal carbohydrate binding module fusion
Authors: Zhang Huifang , Cai Qinzhou , Long Yating , Li Jiajun , Pan Siyu , Yonghua Wang 
Published: September 2024

Abstract

Xylanase from glycoside hydrolases family 11 (GH 11) is widely applied because of their substrate selectivity and broad optimal pH. However, higher thermostability is always preferred in addition to other stress tolerance of the enzyme. Therefore, we first expressed and characterized a novel GH 11 xylanase from Hortaea werneckii (HWxyn11) tolerant to NaCl and extreme pH conditions although still unsatisfied thermostability. To achieve better thermostability, we then constructed mutants by applying N-terminal replacement or C-terminal carbohydrate binding module (CBM) fusion, considering that thermostability of GH 11 xylanase could be affected by structural differences between N-terminus and C-terminus significantly. The combined mutant HWxA31-CBM 6 had increased thermostability than that of HWxyn11. Molecular dynamics simulation analysis reveals that the N-terminal replacement or C-terminal CBM fusion resulted in declined flexibility, indicating the improvement of structural rigidity and thermostability. Structural analysis confirms that the removal of N-terminal propeptide and the fusion of CBM contributed to improved thermostability. Our findings prove that the combination of replacing N-terminal sequences and fusing with CBMs from thermophilic xylanases contributed to declined structural flexibility, providing a practicable method to improve the thermostability of GH 11 xylanases.
Interaction of 1-hexyl-3 methylimidazolium bromide ionic liquid with methylparaben drug
in aqueous solution: Conductometric and molecular dynamics studies
Authors: Gilandooz Roghayeh Darvishi , ghalami-choobar bahram , Mashatooki mohaddeseh habibzadeh 
Published: September 2024

Abstract

In this research, the thermodynamic properties and molecular interactions of 1-hexyl-3-methylimidazolium bromide + methylparaben + water system were reported using conductometric method and molecular dynamics simulations. The conductometric data were collected for ionic liquid from 0.0012 to 0.1983 mol.kg− 1 on various molality of methylparaben in aqueous solution (mMP = 0.0000, 0.0005 and 0.0010 mol.kg− 1) at T = (300.2, 310.2 and 320.2) K and P = 0.1 MPa. Fuoss-Onsager equation was applied to get the ion association constants and limiting molar conductivities of ionic liquid and to determine the thermodynamic of ion association. Moreover, molecular dynamics simulations were made to understand the interactions between ionic liquid and methylparaben at the molecular and microscopic level. Radial distribution functions, root mean square deviations, hydrogen bonding and van der Waals and EL interactions were obtained. Furthermore, the diffusion coefficients of ionic liquid in methylparaben and water mixtures were obtained from MD simulation to calculate the molar conductivity of HMIm]Br using Einstein's Nernst equation at T = 310.2 K and were in agreement with experimental molar conductivity.
Analysis of Factors Affecting Urban Land Use Changes: A Case Study of Urmia City, Iran
Authors: Ziari Keramatollah , Kay Shahriar Hamidi , Qelichi Mohamad Molaei 
Published: September 2024

Abstract

The intricate relationship between human activities and the natural environment has a profound impact on land use patterns. These changes, whether direct or indirect, often lead to a myriad of environmental challenges that jeopardize the well-being of our planet. Therefore, understanding the nature of these transformations and the factors driving them is crucial for ensuring the sustainability of life and mitigating the adverse effects of land use changes. This research adopts an applied approach and follows an exploratory methodology. To identify land use changes, satellite imagery from the years 1993, 2003, 2013, and 2023 was analyzed using the ENVI, GIS, and Google Earth software. The study area encompasses the city of Urmia and its surrounding areas, covering a total of 26,768.7 hectares. The findings reveal a dynamic pattern of land use changes over the three decades from 1993 to 2023.
Machine Learning Computed Tomography Radiomics of Abdominal Adipose Tissue to Optimize Cardiovascular Risk Assessment
Authors: Mancio Jennifer , Lopes Alice , Sousa Inês , Nunes Fabio , Xara Sonia , Carvalho Mónica , Ferreira Wilson , Ferreira Nuno , Barros Antonio , Fontes-Carvalho Ricardo , Ribeiro Vasco Gama , Bettencourt Nuno , Pedrosa Joao 
Published: September 2024

Abstract

Background
Subcutaneous (SAF) and visceral (VAF) abdominal fat have specific properties which the global body fat and total abdominal fat (TAF) size metrics do not capture. Beyond size, radiomics allows deep tissue phenotyping and may capture fat dysfunction. We aimed to characterize the computed tomography (CT) radiomics of SAF and VAF and assess their incremental value above fat size to detect coronary calcification.
Methods
SAF, VAF and TAF area, signal distribution and texture were extracted from non-contrast CT of 1001 subjects (57% male, 57 ± 10 years) with no established cardiovascular disease who underwent CT for coronary calcium score (CCS) with additional abdominal slice (L4/5-S1). XGBoost machine learning models (ML) were used to identify the best features that discriminate SAF from VAF and to train/test ML to detect any coronary calcification (CCS > 0).
Results
SAF and VAF appearance in non-contrast CT differs: SAF displays brighter and finer texture than VAF. Compared with CCS = 0, SAF of CCS > 0 has higher signal and homogeneous texture, while VAF of CCS > 0 has lower signal and heterogeneous texture. SAF signal/texture improved SAF area performance to detect CCS > 0. A ML including SAF and VAF area performed better than TAF area to discriminate CCS > 0 from CCS = 0, however, a combined ML of the best SAF and VAF features detected CCS > 0 as the best TAF features.
Conclusion
In non-contrast CT, SAF and VAF appearance differs and SAF radiomics improves the detection of CCS > 0 when added to fat area; TAF radiomics (but not TAF area) spares the need for separate SAF and VAF segmentations.
Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer's disease: a systematic review and network meta-analysis of randomized controlled trials
Authors: Cai Wenting , Zhang Hui , Wu Yan , Yao Yao , Zhang Jinping 
Published: September 2024

Abstract

Objective: The aim of this study was to compare the efficacy and safety of anti-tau protein monoclonal antibodies for Alzheimer's disease (AD). By investigating the effects of monoclonal antibodies on cognitive function, disease progression, and overall quality of life in patients with AD, which can provide valuable insights into their potential as a therapeutic option for this devastating neurodegenerative disorder.
Methods: The randomized controlled trials (RCTs) of Gosuranemab, Semorinemab, Tilavonemab and Zagotenemab in the treatment of AD were searched in database of PubMed, Embase, Web of Science and Cochrane Library, up to May 2024. The control group included placebo. The efficacy indicators were change in the Mini Mental State Examination (MMSE), Clinical Dementia Rating Scale Sum of Boxes (CDR-SB), Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog), Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale (ADCS-ADL) from baseline until the time of efficacy observation. The statistical analysis was performed by Stata14 and RevMan5.4. Data processing, network evidence plots, surface under the cumulative ranking curve (SUCRA) ranking, league plots and funnel plots were generated. Mean differences (MD) and 95% confidence interval (95%CI) as effect sizes to analyze continuous variables.
Results: This study included six RCTs with 2193 patients. Semorinemab were more effective than placebo in MMSE and ADAS-Cog scores (MDs ranging between 0.52 and 3.21; MDs ranging between 0.17 and 3.30). Placebo showed relatively good efficacy according to SUCRA ranking on change in CDR-SB and ADCS-ADL scores(75.7% and 79.5%). Tilavonemab and Semorinemab exhibited efficacy similar to that of a placebo in the analysis of the two indicators. Tilavonemab showed a lower incidence of AE, SAE, fall, and urinary tract infections than placebo, and the differences were statistically significant. Most safety analysis results showed no statistical difference.
Conclusions: Based on the results of this study, Semorinemab and Tilavonemab were recommended treatment options with relatively good efficacy and safety. These encouraging outcomes suggest that anti-tau protein monoclonal antibodies hold considerable potential as a viable therapeutic option for managing AD. Further exploration and clinical validation are warranted to fully elucidate the long-term effects and optimize treatment protocols in this evolving therapeutic landscape.
Transformation of hazardous residues from medical laboratory waste treatment plant into permeable brick
Authors: Wu Hsing-Hsien , Cheng Li-Chun , Huang Kuo-Lin , Huang Shih-Wei , Kuo Yi-Ming 
Published: September 2024

Abstract

In this study, the transformation of hazardous residues (fly ash, silica gel, bottom ash, and sludge) from a medical laboratory waste incineration system of Sustainable Environment Research Center into permeable bricks was investigated. The fly ash was elutriated using water twice to remove the Cl−. The elutriated fly ash was mixed with silica gel, bottom ash, and sludge with different formulas which were designed using response surface methodology (RSM) in Design Expert 8.0.6 software. The mixed materials were melted at 1450 ℃. The RSM analysis results showed that the most optimal effect was achieved when silica gel constituted 60% of the total sample and the elutriated fly ash constituted 10% of the encapsulated phase (elutriated fly ash, bottom ash, and sludge), in terms of minimizing the amount of unmelted materials and maximizing the percentage of mass reduction. The slag with optimal melting effect was mixed with cullet, clay, cement, and water, molded, cured, and transformed into permeable bricks. The physical properties met the regulations for grade-A bricks, and the Toxicity Characteristic Leaching Procedure (TCLP) results showed that metals were well encapsulated in the permeable bricks. Overall, the permeable bricks will offer sufficient physical strength and will not contribute to environmental pollution when recycled.
Effect of the oxidative phosphorylation signaling pathway related gene CPT1A on pyroptosis after sevoflurane anesthesia
Authors: Han Baoyi , Zhang Yue , Hu Zurong , Zhou Chuanhua , Yang Jingru , Jia Jie , Li Kunwei , Zhang Liangcheng 
Published: September 2024

Abstract

Background
Oxidative phosphorylation signaling pathway plays an important role after anesthesia. However, the link between oxidative phosphorylation related genes (OPRGs) and anesthesia is unclear.
Methods
Transcriptome data was downloaded from the Gene Expression Omnibus (GEO) databases, and 200 OPRGs were obtained from the Molecular Signatures Database (MSigDB). We systematically analyzed the expression profile characteristics of 200 OPRGs and confirmed data quality through tSNE and PCA analysis. Subsequently, the expression level and effect of OPRG carnitine O-palmitoyltransferase 1 (CPT1A) was validated by detected the expression level of inflammation factors. Finally, the activity of pyroptosis pathway was verified after overexpression or knockdown of CPT1A.
Results
We identified that the expression level of OPRGs were significantly regulated after sevoflurane anesthesia. Compared to the control group, the expression of the inflammatory factors IL-1β, IL-6, and TNF-α were increased. Then, the expression level of CPT1A was up-regulated after sevoflurane anesthesia. In addition, the pyroptosis pathway was activated through after upregulating the expression of inflammatory factors.
Conclusion
These findings highlight the effect of OPRG CPT1A during anesthesia, deepen the understanding of OPRGs, inflammation, and pyroptosis for patients in clinic anesthesia.
Advanced selective adsorption of alizarin dye from wastewater using novel nano-magnetic molecularly imprinted polymers
Authors: Rao Qingqing , Zhang Yunlong , Wang Ruru , Li Yuanlian , Yang Shuman , Wu Xinyi , Tong Fei , Kuang Yi , Yuan Bingnan N. , Yang Shengxiang 
Published: September 2024

Abstract

Dye wastewater exhibits a pronounced negative effect on the aquatic environment. However, the selective and efficient adsorption of dye from wastewater presents substantial challenges. Here, a novel surface molecularly imprinted polymer (Alizarin/SMIPs) was developed via an etched nanomagnetic carrier and computer-aided material design. The findings demonstrate that Alizarin/SMIPs exhibit high adsorption efficiency (60.94 mg·g‑1), excellent regeneration (≥ 11 cycles), and excellent magnetic responsive collection (6 s). In addition, the adsorption efficiencies of Alizarin/SMIPs for analogues were significantly lower at 20.26%. Inversely, the recovery rate of Alizarin/SMIPs for Alizarin in wastewater samples can reach 100%. Compared to previous studies, Alizarin/SMIPs demonstrate a high adsorption capacity, selectivity, recovery, and renewability for dye molecules. Besides, the results of the density functional theory (DFT) elucidated the potential interaction forces and binding sites between dye molecules and adsorbents, offering a promising adsorbent for efficient and targeted removal of dye molecules from dyestuff wastewater.
Effects of rheumatoid arthritis on ventricular structure and function: a Mendelian randomization study
Authors: Liu Hao , Luo Di , Yan Wei , Li Jinsong , Yan Dezhi 
Published: September 2024

Abstract

Several observational studies have suggested an association between rheumatoid arthritis (RA) and abnormalities of ventricular structure and function, yet the causal relationship remains unclear. This study aimed to assess the causal association between seropositive and seronegative RA and ventricular structure and function via Mendelian randomization (MR). Genetic data were derived from a genome-wide association study (GWAS) of seropositive and seronegative RA conducted within the FinnGen study, and a GWAS of 16 biventricular functional and structural cardiac magnetic resonance (CMR) measurements involving subjects from the UK Biobank. Inverse variance weighting (IVW) served as the primary analytical strategy to determine the causal associations between seropositive RA, seronegative RA, and ventricular CMR parameters. The MR-Egger, weighted median (WME), weighted mode (WM), and sample mode (SM) methods were employed as supplementary analyses. Additionally, the direct effects of RA on ventricular structure and function were further explored via multivariate MR (MVMR). IVW methods demonstrated that genetically predicted seropositive RA was significantly associated with a reduced left ventricular (LV) stroke volume (adjusted without body surface area (BSA) and systolic blood pressure (SBP)) (OR = 0.635; 95%CI 0.482–0.837; P = 0.001). MVMR analysis indicated that seropositive RA could influence LV stroke volume independently of traditional cardiovascular disease risk factors (OR = 0.695; 95%CI 0.512–0.942; P = 0.019). Sensitivity analyses yielded robust and reliable results. Our genetic analyses revealed a significant causal relationship between the development of seropositive RA and reduced LV stroke volume, offering valuable insights into the prevention and treatment of adverse cardiovascular events in patients with RA.
Feedback Linearization for Robust Deadzone Compensation: Application to LQR-Controlled Cart-Pole System
Authors: Rabie Omar , Elshalakani Mohamed 
Published: September 2024

Abstract

This paper proposes a feedback linearization approach for robust compensation of deadzones in nonlinear mechatronic systems, demonstrating its effectiveness through a case study of a cart-pole system controlled by the Linear Quadratic Regulator (LQR). While the LQR controller offers optimal performance for linear systems, the inherent nonlinearities, deadzone effects, and limit cycles present in non-ideal underactuated systems can significantly compromise its robustness. The proposed deadzone compensation technique aims to augment the LQR controller robustness and resilience to uncertainties while maintaining its inherent optimality and stability. The present solution enforces the linearity of the driving motion unit of the cart-pole system, therefore boosting its asymptotic stability. The deadzone compensator can experimentally eliminate limit cycles arising from different sources of deadzone, restoring the desired converging behaviour of the control system. Over 90% attenuation of the limit cycles could be consistently achieved in the closed loop stabilized response of the physical system.
Identification of multiple miRNA-encoded peptide reveals OsmiPEP162a stabilizes OsMIR162 in rice
Authors: Zhou Jianping , Zhang Rui , Han Qinqing , Yang Hongjun , Wang Wei , Wang Yibo , Zheng Xuelian , Luo Fan , Cai Guangze , Zhang Yong 
Published: September 2024

Abstract

MicroRNAs (miRNAs) are derivatives of primary miRNAs (pri-miRNAs) and govern the expression of target genes. Plant pri-miRNAs encode regulatory peptides known as miPEPs, which specifically boost the transcription of their originating pri-miRNA. Although there are hundreds of pri-miRNAs in rice, research on whether they encode functional peptides is limited. In this study, we identified 10 certainly expressional miPEPs using a transient protoplast expression system. Among these, we focused our attention on OsmiPEP162a, which influences growth. OsmiPEP162a-edited plants exhibited reduced plant height, similar to mature OsmiR162-edited plants. Transcriptome-focused molecular analysis unveiled significant alterations in transcription profiles following the depletion of OsmiPEP162a. Additionally, knocking out OsmiPEP162a led to decreased expression levels of mature OsMIR162a and OsMIR162b. This study suggests that OsmiPEP162a potentially plays a crucial role in stabilizing mature OsMIR162.
Hyperprolactinemia prevents short- and long-term memory deficits in ovariectomized rats and modifies the neuronal morphology of hippocampal CA1 neurons.
Authors: Paniagua-Alegría Verónica , Suárez-Santiago José Eduardo , Cerbón Marco Antonio , Vera-Arzave Carlos , Roldán-Roldán Gabriel , Orozco-Suárez Sandra , Picazo Ofir 
Published: September 2024

Abstract

The pituitary hormone prolactin (PRL) has been traditionally associated to reproductive functions, specifically to lactogenesis. Currently, this hormone has been linked to a great diversity of brain processes such as neurogenesis, neuroprotection, learning and memory formation. Regarding this later, literature is controversial since some studies indicate that PRL, like estrogens, improve some types of memory, while other report the opposite. Implanting pituitary homografts under the renal capsule induces a 10-fold increase of plasmatic PRL in male rats, but its effect on females is unknown. On the other hand, long-term (15 weeks) removal of ovaries produces a clear deficit in memory function by avoiding the action of estrogens and progesterone on this process. The present study was aimed at exploring the putative pro-cognitive actions of endogenous PRL and its role on the morphology of pyramidal neurons from hippocampus. The novel object recognition test, a hippocampal and cortical-dependent memory task was used for evaluating short- and long-term memory, while bromocriptine, a dopaminergic agonist, was assayed to block the actions of PRL on behavioral and morphological parameters. Main results indicate that PRL prevents the cognitive deficit observed in ovariectomized rats and increases the mushroom spines in CA1 pyramidal neurons; an effect that was partially impeded by bromocriptine.
Characteristics and Factors Associated with Diameter Deviation of Rhexis Reference Circle Generated by an Image-Guided System in Cataract Surgery: A Cross-Sectional Study
Authors: Fu Yabo , Huang Yulong , Liu Xiaobao , Kang Chishan , Wu Wenjie , Li Qiong 
Published: September 2024

Abstract

More attention should be paid to the deviations between the actual diameter of the rhexis reference circle which projected by the Image-guided systems and its intended size, and assess the influence of ocular biometric parameters on the deviation. In this study, the Callisto eye image-guided system was employed to generate a digital rhexis reference circle (rhexis overlay) set at an intended diameter of 6 mm and a screenshot of the video was taken at the end of the cataract surgery, then to compare the deviation between the observed rhexis overlay diameter (ROD) and the optic diameter (6 mm) . The factors influencing diameter deviation were identified with univariate and multivariate linear regression. Subgroup analyses were conducted based on factors identified in the multivariate regression. And we observed that a total of 213 eyes of 174 patients were included in the final analysis. The diameter deviation averaged -0.24 ±0.28 mm (P = 0.0001) and was positively correlated with phakic anterior chamber depth (ACD) (P < 0.001) and negatively correlated with white-to-white (WTW) measurement (P < 0.001). Subgroup analyses revealed significantly greater diameter deviation in cases with preoperative ACD < 2.5 mm and WTW ≥ 12.0 mm (all P < 0.05). Following optimization, the mean diameter deviation was 0.00047 ± 0.26 mm (P > 0.05). In conclusion, the Callisto eye image-guided system demonstrates good precision in CCC assistance. However, there remains a slight deviation from the intended size when generating the rhexis reference circle in eyes with shallow anterior chambers and larger corneas. Implementing an optimization process could be beneficial for these eyes.