bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Maternal Body Mass Index on Intrapartum and Neonatal Outcomes in Brisbane, Australia, 2007 to 2013
Authors: Foo Xin Y. , Greer Ristan M. , Kumar Sailesh 
Published: August 2016

AbstractBackgroundThe aim of this study was to evaluate the influence of maternal body mass index on intrapartum and neonatal outcomes at one of the largest maternity hospitals in Australia.MethodsA retrospective cross‐sectional study of 55,352 term singleton deliveries at the Mater Mothers’ Hospital in Brisbane, Australia, was conducted. The study cohort was stratified into six groups based on the World Health Organization's body mass index classification. The normal body mass index category was the reference group for all comparisons. Multivariate logistic regression was used to examine the effect of maternal body mass index, adjusted for maternal age, ethnicity, parity, and preexisting conditions (e.g., diabetes mellitus and hypertension), on selected intrapartum and neonatal outcomes.ResultsWomen in the overweight and Obese I, II, and III categories were more likely to have chronic or gestational hypertension/preeclampsia, and preexisting or gestational diabetes mellitus. They also had an increased risk for induction of labor, elective and emergency cesarean, and postpartum hemorrhage. Underweight women were less likely to require induction of labor and emergency cesarean. Infants born to women with increased body mass index were more likely to require neonatal resuscitation, neonatal intensive care unit admission, and have lower Apgar scores at 5 minutes.ConclusionThere is an increased risk of adverse intrapartum and neonatal outcomes for women who are overweight and obese, with the risks increasing with rising body mass index. Appropriately targeted weight management strategies and health education may yield improved maternal and perinatal outcomes if effectively implemented before pregnancy. These may particularly be of benefit in the teenage cohort that has yet to embark on pregnancy.
Guidelines for creating framework data for GIS analysis in low‐ and middle‐income countries
Authors: Makanga Prestige Tatenda , Schuurman Nadine , Sacoor Charfudin , Boene Helena , von Dadelszen Peter , Firoz Tabassum 
Published: August 2016

Key Messages

While some framework data are available in LMICs, there is a lack of coordinated effort to create and share these data to support health GIS research in these settings.
Manual digitizing can be used to generate framework data, and is increasingly becoming cheaper and faster due to widely available free satellite imagery and open mapping standards that allow distributed data capture.
Efforts to create framework data should be done in collaboration with local mapping authorities that have the mandate for creating these data at scale.
Design and synthesis of new 2‐anilinoquinolines bearing N‐methylpicolinamide moiety as potential antiproliferative agents
Authors: El‐Damasy Ashraf Kareem , Seo Seon Hee , Cho Nam‐Chul , Pae Ae Nim , Kim Eunice Eunkyeong , Keum Gyochang 
Published: August 2016

A series of new 2‐anilinoquinolines 6a–o possessing the substantial N‐methylpicolinamide motif at C5 has been designed and synthesized as sorafenib analogs. The antiproliferative activities of the target compounds were preliminarily appraised against a panel of three human cancer cell lines (MCF‐7, SK‐BR3, and HCT116), and a selected array was further tested over a panel of approximately 60 cancer cell lines at NCI at 10 μM concentration. Interestingly, compounds 6c, 6d, 6j, 6k, and 6l showed promising selective anticancer activities (growth inhibition >80%) toward certain cancer cells at 10 μM testing dose. Compounds 6d and 6j were advanced to five‐dose testing mode to determine their GI50 values and compared with our previously reported ureidoquinoline B and sorafenib as reference compounds. The 4‐chloro‐3‐trifluoromethylaniline derivative 6j manifested superior potency than both compound B and sorafenib over eleven and eight cell lines, respectively. It showed GI50 values of 0.36, 0.66, 0.68, and 0.60 μM against the breast MDA‐MB‐468, renal A498, and melanoma SK‐MEL‐5 and UACC‐62 cell lines, respectively. Moreover, both 6d and 6j exerted low cytotoxic effects against HFF‐1 normal cell line. Furthermore, compounds 6d and 6j were tested against both B‐RafV600E and C‐Raf kinases and displayed modest inhibitory activities, which were justified by molecular docking study. Compound 6j could serve as a promising candidate for further development of potent anticancer chemotherapeutics.
Subjective sleep measures for adolescents: a systematic review
Authors: Ji X. , Liu J. 
Published: August 2016

AbstractBackgroundSleep disturbances in adolescents have received significant attention because of their high prevalence and the negative health outcomes. Relative to objective measures, subjective sleep instruments have been the most practical tools used to identify sleep problems and assess responses to interventions in research and clinical settings. This systematic review aims to examine the psychometric properties of subjective measures that are used to assess sleep quality and disturbances among adolescents, identify the strength and limitation of each measurement and inform recommendations for practice.MethodsPubMed, Embase and PsycInfo were searched from 2000 through May 2016. The reference lists of important articles were included if they met the inclusion criteria. The available measures were evaluated and classified as positive, intermediate or poor according to the quality criteria for health status questionnaires.ResultsThirteen self‐reported or parent‐reported sleep measures met the inclusion criteria. Of the measurements reviewed, six were generic instruments assessing overall sleep quality and disturbances; five were dimension‐specific instruments measuring daytime sleepiness, sleep insufficiency and sleep hygiene; and two were condition‐specific instruments for insomnia. None of the subjective sleep measures for adolescents has a psychometric profile with all essential measurement properties. Specifically, the generic sleep measurements capture multiple dimensions but face issues of participant burden and compatibility. Among the domain‐specific tools, the Cleveland Adolescent Sleepiness Questionnaire and the Chronic Sleep Reduction Questionnaire have achieved good psychometric merits but need further evaluation for responsiveness. Likewise, essential measurement properties of condition‐specific tools for insomnia have yet to be established.ConclusionsBecause of the limited evidence, no definite recommendations can be made at this point. However, each available measurement has its own uniqueness and strength despite the limitations. Future research on measurement development and evaluation for adolescent sleep is needed to ensure the relevance and suitability to different stages of adolescence and social contexts.
Half‐century of Dental Public Health research: bibliometric analysis of world scientific trends
Authors: Celeste Roger Keller , Broadbent Jonathan M. , Moyses Samuel Jorge 
Published: August 2016

AbstractObjectivesTo describe the characteristics of Dental Public Health (DPH) scientific publications within core DPH journals over time and to compare DPH journals with DPH content from other journal types.MethodsThe Scopus database was used to identify DPH‐relevant articles published from 1965 to 2014 in three core DPH journals (DPHJs) and from 2005 to 2014 in Dental Journals (DJs), Public Health (PHJs) and General Journals (GJs). To identify DPH‐relevant articles, a search strategy with words about oral health and public health was applied to each group of journals. Research themes were created by grouping similar keywords to report changes in the focus of articles over time. The most productive journals, countries, institutions and authors were also estimated for each set of journals.ResultsIn 2005–2014, 60 297 articles were identified, of which 2.7% in DPHJs, 10.4% from PHJs, 38.2% from GJs and 48.7% from DJs. DPH‐relevant articles published in the core DPHJs, DJs and PHJs tended to share a strong emphasis on dental caries, healthcare/services research on children and adolescents. Over time, the focus in the DPHJs has increased towards health behaviour/promotion/education, quality of life and socioeconomic factors. In the last decade, those themes were more frequent in DPH journals than in the other groups.ConclusionsDPH research published in DPHJs had some unique features and greater focus on the themes of quality of life, socioeconomic factors and health behaviour/education/promotion than other groups of journals.
Adjuvant endocrine therapy in women with oestrogen‐receptor‐positive breast cancer: how should the skeletal and vascular side effects be assessed and managed?
Authors: Ramchand Sabashini K. , Lim Elgene , Grossmann Mathis 
Published: August 2016

SummaryAdjuvant endocrine therapy provides oncological benefits in women with early oestrogen‐receptor‐positive breast cancer, but has adverse effects consequent to induced oestradiol deficiency. Bone loss is accelerated, predisposing to increased fracture risk. Metabolic effects include changes in lipid metabolism and body composition although effects on cardiovascular risk are still unclear. Women commencing endocrine therapy should be proactively counselled about and monitored for these and other therapy‐related complications including arthralgia and vasomotor symptoms. We provide strategies for prevention and management of these adverse effects, based, where available, on randomized controlled trial evidence specific to breast cancer survivors receiving endocrine treatment.
Bone turnover markers and bone mineral density in healthy mother–daughter pairs from South India
Authors: Shetty Sahana , Kapoor Nitin , Dian Bondu Joseph , Antonisamy Belavendra , Thomas Nihal , Paul Thomas Vizhalil 
Published: August 2016

SummaryBone turnover markers (BTMs) provide important insights into the dynamics of bone remodelling and are subjected to preanalytical and ethnic variations in addition to influence of genetic and environmental factors.Aim/ObjectivesTo derive ethnicity specific reference range for BTMs and to study their correlation with Bone Mineral Density (BMD) in a cohort of healthy postmenopausal women and their premenopausal daughters and to look at the impact of maternal bone mineral status on daughters bone health.Material and MethodsThis community based cross sectional study included 300 subjects (150 mother‐daughter pairs). Demographic details were collected. Fasting blood and a second void morning urine samples were obtained for measurement of BTMs (sCTX, sPTNP1, sOC and urine DPD respectively) and bone mineral parameters. BMD was measured by DXA scan.ResultsOsteoporosis was seen in 44·7% of the postmenopausal women. Ethnicity specific reference ranges of BTMs were derived for the study population. Significant inverse correlation was found between all BTMs (except urine DPD) and BMD(P < 0·05). Daughters of mothers with osteoporosis at spine and femoral neck had lower BMD, compared to daughters of mothers without osteoporosis(P = 0·03 & 0·05).ConclusionApart from deriving the ethnicity specific reference range for BTMs and finding a significant inverse correlation between BTM and BMD, this study found significantly lower BMD in daughters of mothers with osteoporosis at spine and femoral neck implicating the probable interplay of genetic, epigenetic and similar environmental factors.
Are the literacy difficulties that characterize developmental dyslexia associated with a failure to integrate letters and speech sounds?
Authors: Nash Hannah M. , Gooch Debbie , Hulme Charles , Mahajan Yatin , McArthur Genevieve , Steinmetzger Kurt , Snowling Margaret J. 
Published: August 2016

AbstractThe ‘automatic letter‐sound integration hypothesis’ (Blomert, ) proposes that dyslexia results from a failure to fully integrate letters and speech sounds into automated audio‐visual objects. We tested this hypothesis in a sample of English‐speaking children with dyslexic difficulties (N = 13) and samples of chronological‐age‐matched (CA; N = 17) and reading‐age‐matched controls (RA; N = 17) aged 7–13 years. Each child took part in two priming experiments in which speech sounds were preceded by congruent visual letters (congruent condition) or Greek letters (baseline). In a behavioural experiment, responses to speech sounds in the two conditions were compared using reaction times. These data revealed faster reaction times in the congruent condition in all three groups. In a second electrophysiological experiment, responses to speech sounds in the two conditions were compared using event‐related potentials (ERPs). These data revealed a significant effect of congruency on (1) the P1 ERP over left frontal electrodes in the CA group and over fronto‐central electrodes in the dyslexic group and (2) the P2 ERP in the dyslexic and RA control groups. These findings suggest that our sample of English‐speaking children with dyslexic difficulties demonstrate a degree of letter‐sound integration that is appropriate for their reading level, which challenges the letter‐sound integration hypothesis.
A computational biomarker of idiopathic generalized epilepsy from resting state EEG
Authors: Schmidt Helmut , Woldman Wessel , Goodfellow Marc , Chowdhury Fahmida A. , Koutroumanidis Michalis , Jewell Sharon , Richardson Mark P. , Terry John R. 
Published: August 2016

SummaryEpilepsy is one of the most common serious neurologic conditions. It is characterized by the tendency to have recurrent seizures, which arise against a backdrop of apparently normal brain activity. At present, clinical diagnosis relies on the following: (1) case history, which can be unreliable; (2) observation of transient abnormal activity during electroencephalography (EEG), which may not be present during clinical evaluation; and (3) if diagnostic uncertainty occurs, undertaking prolonged monitoring in an attempt to observe EEG abnormalities, which is costly. Herein, we describe the discovery and validation of an epilepsy biomarker based on computational analysis of a short segment of resting‐state (interictal) EEG. Our method utilizes a computer model of dynamic networks, where the network is inferred from the extent of synchrony between EEG channels (functional networks) and the normalized power spectrum of the clinical data. We optimize model parameters using a leave‐one‐out classification on a dataset comprising 30 people with idiopathic generalized epilepsy (IGE) and 38 normal controls. Applying this scheme to all 68 subjects we find 100% specificity at 56.7% sensitivity, and 100% sensitivity at 65.8% specificity. We believe this biomarker could readily provide additional support to the diagnostic process.
Ocean acidification has little effect on developmental thermal windows of echinoderms from Antarctica to the tropics
Authors: Karelitz Sam E. , Uthicke Sven , Foo Shawna A. , Barker Mike F. , Byrne Maria , Pecorino Danilo , Lamare Miles D. 
Published: August 2016

AbstractAs the ocean warms, thermal tolerance of developmental stages may be a key driver of changes in the geographical distributions and abundance of marine invertebrates. Additional stressors such as ocean acidification may influence developmental thermal windows and are therefore important considerations for predicting distributions of species under climate change scenarios. The effects of reduced seawater pH on the thermal windows of fertilization, embryology and larval morphology were examined using five echinoderm species: two polar (Sterechinus neumayeri and Odontaster validus), two temperate (Fellaster zelandiae and Patiriella regularis) and one tropical (Arachnoides placenta). Responses were examined across 12–13 temperatures ranging from −1.1 °C to 5.7 °C (S. neumayeri), −0.5 °C to 10.7 °C (O. validus), 5.8 °C to 27 °C (F. zelandiae), 6.0 °C to 27.1 °C (P. regularis) and 13.9 °C to 34.8 °C (A. placenta) under present‐day and near‐future (2100+) ocean acidification conditions (‐0.3 pH units) and for three important early developmental stages 1) fertilization, 2) embryo (prehatching) and 3) larval development. Thermal windows for fertilization were broad and were not influenced by a pH decrease. Embryological development was less thermotolerant. For O. validus, P. regularis and A. placenta, low pH reduced normal development, albeit with no effect on thermal windows. Larval development in all five species was affected by both temperature and pH; however, thermal tolerance was not reduced by pH. Results of this study suggest that in terms of fertilization and development, temperature will remain as the most important factor influencing species' latitudinal distributions as the ocean continues to warm and decrease in pH, and that there is little evidence of a synergistic effect of temperature and ocean acidification on the thermal control of species ranges.
Self‐perceived taste disturbance: a 20‐year prospective study of a Swedish 1942 birth cohort
Authors: Ekbäck Gunnar , Ordell Sven 
Published: August 2016

ObjectivesThe aim of this study was to assess the impact of dental care factors, general health factors and socio‐economic factors on perceived taste disturbance (PTD) over time and to assess the stability of or change in PTD in a panel of individuals as they progressed from middle age (50 years) to early old age (70 years).Materials and methodsData collection was conducted from a cohort study beginning in 1992, when the participants were 50 years old, and again 5, 10, 15 and 20 years later. Stability and change in PTD were described using cross‐tabulation. Perceived taste disturbance over the 20‐year survey period was modelled using the generalised estimating equation (GEE).ResultsThe prevalence of PTD during a 5‐year period found in this study ranged from 2.4 to 2.9%, the latter in individuals between 60 and 70 years of age. Women generally had PTD more often than men. The longitudinal analysis showed that problems with bad breath (OR = 3.6), blisters (OR = 3.4), burning mouth (OR = 3.4) and self‐perceived health (OR = 2.7) were the most important factors explaining PTD.ConclusionsThis study showed that PTD does not increase between 50 and 70 years of age in ordinary community‐living individuals. There were no long‐term impacts on PTD over time from socio‐economic factors, and over time, there were a limited number of factors contributing to the effect. Bad breath, blisters, burning mouth and self‐perceived health are important factors for the dentist to discuss with the patient in the case of PTD.
Validated programmed cell death ligand 1 immunohistochemistry assays (E1L3N and SP142) reveal similar immune cell staining patterns in melanoma when using the same sensitive detection system
Authors: Schats Kelly A , Van Vré Emily A , De Schepper Stefanie , Boeckx Carolien , Schrijvers Dorien M , Waelput Wim , Fransen Erik , Vanden Bempt Isabelle , Neyns Bart , De Meester Ingrid , Kockx Mark M 
Published: August 2016

AimsTumour cell and/or immune cell programmed cell death ligand 1 (PD‐L1) expression is considered as a potential biomarker for anti‐PD1 and anti‐PD‐L1 immunotherapy. Currently, different PD‐L1 assays are used. This study aims to compare the staining patterns of two PD‐L1 antibody clones in melanoma metastases and correlate them with PD‐L1 mRNA expression.Methods and resultsThe immunohistochemistry assays were optimized and validated independently on a Ventana Benchmark Ultra (Ventana Medical Systems Inc., Tucson, AZ, USA) (E1L3N) and XT (SP142), using the same detection system. In total, 46 melanoma metastases were stained with both validated immunohistochemistry assays. Stained slides were digitized for qualitative and semi‐quantitative evaluation; done by pathologist and semi‐automated software analysis. A subset of 21 melanoma metastases was selected for quantification of the PD‐L1 mRNA expression. Accuracy and precision criteria were met for both assays. PD‐L1 protein and mRNA expression showed remarkably good Spearman's coefficients of 0.90 (E1L3N) and 0.87 (SP142). Despite the remarkable correlation between both PD‐L1 assays in expression patterns and quantification values (ρ > 0.90), E1L3N showed significantly more tumour cell staining than SP142.ConclusionsE1L3N and SP142 IHC assays were optimized and validated successfully and independently for sensitive and accurate PD‐L1 detection. Concordance was best for immune cell scoring, while E1L3N tended to detect more tumour cells. Determination of the clinically relevant cut‐off values for immune cell versus tumour cell detection requires further research.
Reducing laundering frequency to prolong the life of denim jeans
Authors: McQueen Rachel H. , Batcheller Jane C. , Moran Lori J. , Zhang Han , Hooper Peter M. 
Published: August 2016

AbstractThe use and disposal phase in a garment's life cycle is highly dependent on the choices made by the consumer. Maintenance procedures such as laundering and drying require energy and water use. Garment disposal increases waste in landfill sites, unless incinerated, which can take a toll on the environment through greenhouse gas emissions. Therefore, encouraging consumers to launder less frequently and finding ways to extend the useful life of clothing are two ways of increasing sustainability within the clothing industry. Denim jeans are one of the most popular items of clothing worldwide. Changing habits such as reducing the frequency with which a person washes their denim jeans could have a positive impact on the environment through less water and energy use. However, environmental knowledge about what is detrimental to the environment may not necessarily lead to pro‐environmental behaviour. In denim jeans fibre loss results in thinning and loss in colour due to use. Laundering in particular can degrade clothing due to the abrasive forces applied to the surface of wet fibres. Therefore, this study highlights the effect that frequent laundering can have on the degradation of jeans with the aim to provide additional motivation to encourage change in consumers’ laundering habits. Consumers wore jeans for the equivalent of 60 days and either washed their jeans after approximately 2 days of wear or after approximately every 20 days of wear. The findings confirmed that frequent laundering reduced mass, increased colour loss, and reduced tensile strength in the warp direction of the fabric. Although washing is a major contributor to the degradation of jeans, the process of wearing denim jeans also naturally degrades the denim as the thigh region of the jeans showed greater colour loss and reduction in tensile strength than the shin region, which is typically less prone to abrasion through wear. The findings from this study provide compelling evidence to encourage consumers to reconsider their laundering habits in terms of wash frequency as both a means to behave in a more environmentally sustainable way, and to preserve their favourite garments.
Impact of various maceration techniques on the phenolic and volatile composition of Chenin Blanc wines
Authors: Wang Jun , Huo Sufang , Zhang Yuxiu , Liu Yaping , Fan Weixin 
Published: August 2016

SummaryChenin Blanc, cultivated in cool climate regions, was chosen to evaluate the impact of different maceration techniques on polyphenolic profiles and volatile compounds. Control with no skin contact (CK), cold maceration (CM), cryogenic maceration (CR), separate fermentation before blending (SFB) and extended skin contact during fermentation (ESF) were the five maceration techniques being studied. SFB and ESF techniques resulted in significantly increased polyphenolic compounds compared to the control (P < 0.05), while CM and CR maceration techniques resulted in almost no effect. Meanwhile, for aromatic components, the maximum change was observed in ESF wine, which had significantly highest levels of terpenes, alcohols, esters and acids. However, compared with control wine, CR wine had higher levels of terpenes and esters and SFB wine had higher levels of terpenes and alcohols. This study provides information about prefermentation techniques and additional options for oenologists to produce Chenin Blanc wines with different characteristics.