bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracted: Studies on the luminescence properties of cerium co‐doping on Ca2MgSi2O7:Eu2+ phosphor by solid‐state reaction method
Authors: Sahu Ishwar Prasad , Bisen D. P. , Murthy K. V. R. , Tamrakar R. K. 
Published: May 2017

AbstractCa2MgSi2O7:Ce3+, Ca2MgSi2O7:Eu2+ and Ca2MgSi2O7:Eu2+,Ce3+ phosphors were prepared using the solid‐state reaction method. The crystal structures of the sintered phosphors were of melilite type, which has a tetragonal crystallography. The chemical compositions of the sintered phosphors was confirmed by energy dispersive X‐ray spectroscopy. The different thermoluminescence kinetic parameters [activation energy (E), frequency factor (s) and order of the kinetics (b)] of these phosphors were evaluated and compared using the peak shape method. Under ultraviolet excitation, the emission spectra of both Ca2MgSi2O7:Eu2+ and Ca2MgSi2O7:Eu2+,Ce3+ phosphors were composed of a broad emission band peaking at 530 nm. When the Ca2MgSi2O7:Eu2+ phosphor is co‐doped with Ce3+ ions, photoluminescence, afterglow and mechanoluminescence intensity was strongly enhanced. Ca2MgSi2O7:Eu2+ showed some afterglow with a short persist time. On incorporation of Ce3+, efficient energy transfer from Ce3+ to Eu2+ was found and the emission intensity of Eu2+ was enhanced. The mechanoluminescence intensities of Ca2MgSi2O7:Ce3+, Ca2MgSi2O7:Eu2+ and Ca2MgSi2O7:Eu2+,Ce3+ phosphors increased proportionally increased with the increase in impact velocity, which suggests that these phosphors can be used as sensors to detect stress in an object.
Design and chemical syntheses of potent matriptase‐2 inhibitors based on trypsin inhibitor SFTI‐1 isolated from sunflower seeds
Authors: Gitlin‐Domagalska Agata , Dębowski Dawid , Łęgowska Anna , Stirnberg Marit , Okońska Joanna , Gütschow Michael , Rolka Krzysztof 
Published: May 2017

AbstractMatriptase‐2 plays a pivotal role in keeping iron concentrations within a narrow physiological range in humans. The opportunity to reduce matriptase‐2 proteolytic activity may open a novel possibility to treat iron overload diseases, such as hereditary hemochromatosis and thalassemia. Here, we present 23 new analogues of trypsin inhibitor SFTI‐1 designed to inhibit human matriptase‐2. Influence of the modifications Gly1Lys, Ile10Arg, and Phe12His, as well as the introduction of Narg in P1 or P1 and P4 positions were examined. Selected peptides were further analyzed, together with previously reported peptides, for their inhibitory activity against related human proteases, that are, matriptase‐1, plasmin, thrombin and trypsin. A highly potent inhibitor of matriptase‐2, the bicycylic [Arg5, Arg10, His12]SFTI‐1, with aKivalue of 15 nmwas obtained.
A review of chromatographic methods for ketamine and its metabolites norketamine and dehydronorketamine
Authors: Göktaş Eylem Funda , Arıöz Filiz 
Published: May 2017

AbstractKetamine has a synthetic, sedative, nonbarbiturate and fast‐acting anaesthetic properties and it is commonly used in both humans and veterinary surgery. There are many analytical methods available for the qualitative and quantitative determination of ketamine and its metabolites. We have focused on sample pre‐treatment and chromatographic techniques used since the year 2000 for the determination of ketamine and its metabolites in biological samples. Liquid and gas chromatography coupled with various detection techniques (mass spectrometry, ultraviolet or fluorescence detection) have been used in these publications. This review gives information on the implementation of methods for studying ketamine and its metabolites in various research applications. It could be useful in forensic sciences including doping control and also in the therapeutic drug monitoring of ketamine and norketamine in human and animal clinical surgery.
Ultrasonography‐driven combination antibiotic therapy with tigecycline significantly increases survival among patients with neutropenic enterocolitis following cytarabine‐containing chemotherapy for the remission induction of acute myeloid leukemia
Authors: Pugliese Novella , Salvatore Paola , Iula Dora Vita , Catania Maria Rosaria , Chiurazzi Federico , Della Pepa Roberta , Cerchione Claudio , Raimondo Marta , Giordano Claudia , Simeone Luigia , Caruso Simona , Pane Fabrizio , Picardi Marco 
Published: May 2017

AbstractNeutropenic enterocolitis (NEC) is an abdominal infection reported primarily in patients with acute myeloid leukemia (AML) following chemotherapy, especially cytarabine, a notable efficacious cytotoxic agent for AML remission. Specific data regarding the impact of different cytarabine schedules and/or antibacterial regimens for NEC are sparse. The aim of the study was to identify the predictors of outcome within 30 days of NEC onset. NEC episodes were retrospectively pinpointed among 440 patients with newly diagnosed AML hospitalized in our Institution, over a 10‐year period, for receiving chemotherapy protocols with 100–6000 mg/m2 daily of cytarabine. Two subgroups, survivors versus nonsurvivors, were compared by using logistic regression analysis. NEC was documented in 100 of 420 (23.8%) analyzed patients: 42.5% had received high‐dose cytarabine, whereas 19% and 15% intermediate‐dose and standard‐dose cytarabine, respectively (P < 0.001). The 30‐day NEC attributable mortality rate was 23%. In univariate analysis, antileukemic protocols containing robust dosages of cytarabine were significantly associated with high mortality (P < 0.001); whereas, standard‐dose cytarabine and prompt initiation (at the ultrasonographic appearance of intestinal mural thickening) of NEC therapy with antibiotic combinations including tigecycline were significantly associated with low mortality. In multivariate analysis, high‐dose cytarabine‐containing chemotherapy was the independent predictor of poor outcome (odds ratio [OR]: 0.109; 95% confidence interval [CI]: 0.032–0.364; P < 0.001), whereas ultrasonography‐driven NEC therapy with antibiotic regimens including tigecycline was associated with a favorable outcome (OR: 13.161; 95% CI: 1.587–109.17; P = 0.017). Chemotherapy schedules with robust dosages of cytarabine for AML remission are associated with a high rate of NEC incidence and attributable. Vigorous antibacterial therapy, triggered off pathologic ultrasonographic findings, with drug combinations which have broad antimicrobial coverage and good gut penetration, specifically those also including tigecycline, may be effective in improving 30‐day survival rate after NEC onset.
A three‐gene signature from protein–protein interaction network of LOXL2‐ and actin‐related proteins for esophageal squamous cell carcinoma prognosis
Authors: Zhan Xiu‐hui , Jiao Ji‐wei , Zhang Hai‐feng , Li Chun‐quan , Zhao Jian‐mei , Liao Lian‐di , Wu Jian‐yi , Wu Bing‐li , Wu Zhi‐yong , Wang Shao‐hong , Du Ze‐peng , Shen Jin‐hui , Zou Hai‐ying , Neufeld Gera , Xu Li‐yan , Li En‐min 
Published: May 2017

AbstractCurrent staging is inadequate for predicting clinical outcome of esophageal squamous cell carcinoma (ESCC). Aberrant expression of LOXL2 and actin‐related proteins plays important roles in ESCC. Here, we aimed to develop a novel molecular signature that exceeds the power of the current staging system in predicting ESCC prognosis. We found that LOXL2 colocalized with filamentous actin in ESCC cells, and gene set enrichment analysis (GSEA) showed that LOXL2 is related to the actin cytoskeleton. An ESCC‐specific protein–protein interaction (PPI) network involving LOXL2 and actin‐related proteins was generated based on genome‐wide RNA‐seq in 15 paired ESCC samples, and the prognostic significance of 14 core genes was analyzed. Using risk score calculation, a three‐gene signature comprising LOXL2, CDH1, and FN1 was derived from transcriptome data of patients with ESCC. The high‐risk three‐gene signature strongly correlated with poor prognosis in a training cohort of 60 patients (P = 0.003). In mRNA and protein levels, the prognostic values of this signature were further validated in 243 patients from a testing cohort (P = 0.001) and two validation cohorts (P = 0.021, P = 0.007). Furthermore, Cox regression analysis revealed that the signature was an independent prognostic factor. Compared with using the signature or TNM stage alone, the combined model significantly enhanced the accuracy in evaluating ESCC prognosis. In conclusion, our data reveal that the tumor‐promoting role of LOXL2 in ESCC is mediated by perturbing the architecture of actin cytoskeleton through its PPIs. We generated a novel three‐gene signature (PPI interfaces) that robustly predicts poor clinical outcome in ESCC patients.
A state‐wide initiative to promote genetic testing in an underserved population
Authors: Underhill Meghan L. , Blonquist Traci M. , Habin Karleen , Lundquist Debra , Shannon Kristen , Robinson Kathryn , Woodford Mary‐Lou , Boucher Jean 
Published: May 2017

AbstractGenetic testing for cancer susceptibility has been widely studied and utilized clinically. Access to genetic services in research and practice is largely limited to well‐insured, Caucasian individuals. In 2009, the Cancer Resource Foundation (CRF) implemented the Genetic Information for Treatment Surveillance and Support (GIFTSS) program to cover the out‐of‐pocket expenses associated with cancer genetic testing, targeting high‐risk individuals with limited financial means and limited health insurance coverage. Here, we (i) describe the characteristics of participants in the Massachusetts (MA) GIFTSS program and (ii) evaluate mutations found in this diverse sample. A secondary retrospective data analysis was performed using de‐identified demographic data obtained from laboratory requisition forms and cancer genetic testing result information from the laboratory source. Eligible participants were those who utilized the MA GIFFTS program from 2009 through December of 2014. Data were summarized using descriptive measures of central tendency. Participants were residents of Massachusetts who had health insurance and had a reported income within 250–400% of the federal poverty level. Genetic testing results were categorized following clinical guidelines. Overall, 123 (13%) of participants tested positive for a mutation in a cancer susceptibility gene. For those with a cancer diagnosis, 65 (12%) were found to have a positive result and 20 (7%) had a variant of uncertain significance (VUS). For those unaffected patients, 58 (15%) had a positive result and 10 (3%) were found to have a VUS. The results from this study are useful in describing genetic testing outcomes in this high‐risk underserved community. Repeatedly, the literature reports that individuals from diverse or limited resource settings are less likely to access genetic testing. Continued research efforts should be devoted to promoting the access of genetic testing in the high‐risk, underserved community.
Comparative molecular profiling of HPV‐induced squamous cell carcinomas
Authors: Koncar Robert F. , Feldman Rebecca , Bahassi El Mustapha , Hashemi Sadraei Nooshin 
Published: May 2017

AbstractApproximately 5% of all cancer incidences result from human papillomavirus (HPV) infection. HPV infection most commonly leads to cancers of the anogenital region or oropharynx. It is unknown whether different HPV‐mediated cancers collectively share a molecular signature and it is important to determine if there are targetable alterations common to different types of HPV‐positive tumors. We analyzed 743 p53 wild‐type samples of anal, cervical, oropharyngeal, and vulvar squamous cell carcinomas which underwent multiplatform testing at a commercial molecular profiling service. Expression of 24 proteins was measured by immunohistochemistry (IHC), mutation of 48 genes was determined by next‐generation and Sanger sequencing, and copy number alteration for six genes was determined by in situ hybridization. The four cohorts had remarkably similar molecular profiles. No gene had a statistically significant difference in mutation frequency or copy number change between the four different types of squamous cell carcinomas. The only significant differences between cohorts were frequency of ERCC1 and SPARC loss as determined by IHC. In all four cancer types, oncogene mutation and PD‐L1 expression was relatively infrequent. The most commonly mutated gene was PIK3CA, with mutations most often affecting the helical domain of the protein and accompanied by concurrent lack of PTEN expression. Loss of MGMT and RRM1 was common among the four cohorts and may be predictive of response to cytotoxic therapies not currently being used to treat these cancer types. The similar molecular profiles of the four cohorts indicate that treatment strategies may be similarly efficacious across HPV‐positive cancers.
Influence of Metal Doping on the Lewis Acid Catalyzed Production of Butadiene from Ethanol Studied by using Modulated Operando Diffuse Reflectance Infrared Fourier Transform Spectroscopy and Mass Spectrometry
Authors: Müller Philipp , Wang Shao‐Chun , Burt Samuel P. , Hermans Ive 
Published: May 2017

AbstractAs a result of the increasing gap between the supply and demand of butadiene, the catalytic coupling of ethanol has regained the attention of the scientific and industrial community as an “on‐purpose” production route to butadiene. The most promising systems are based on bifunctional catalysts that comprise metal sites that can dehydrogenate ethanol to acetaldehyde and Lewis acid sites that catalyze the aldol condensation between two aldehyde molecules and the Meerwein–Ponndorf–Verley reduction of the intermediate crotonaldehyde. Here, we investigate the role of Ag in an established Ag‐Zr‐BEA catalyst using modulated operando diffuse reflectance infrared Fourier transform spectroscopy and mass spectrometry experiments. We obtain insights into the complex reaction network that involves several consecutive and parallel reactions. Based on our investigations, we formulate suggestions for catalyst optimization.
A Composite of Pyrrole‐Doped Carbon Black Modified with Co3O4 for Efficient Electrochemical Oxygen Reduction Reaction
Authors: Liu Zhidong , Su Qingyun , Diao Peng , Li Fan 
Published: May 2017

AbstractLow‐cost catalysts with high performance toward the oxygen reduction reaction (ORR) in energy conversion systems are intensively desired. Here, we report the preparation of a composite catalyst that is composed of pyrrole‐doped carbon black (py‐CB) and Co3O4 nanoparticles (NPs). The synergetic effect of Co3O4 and pyrrole on CB particles endows the obtained py‐CB/Co3O4 hybrid with pronounced catalytic activity toward the ORR. The onset potential of the hybrid is 0.88 V vs. RHE and the half‐wave potential is only 60 mV negative from that of the commercial Pt/C catalyst. The diffusion‐limit current density of this catalyst reaches 5.47 mA cm−2, which is very close to that of Pt/C. The electron‐transfer number of ORR on the py‐CB/Co3O4 is 3.9, indicating a desirable four‐electron reduction pathway. Moreover, the hybrid catalyst exhibits a much higher durability toward the ORR than the commercial Pt/C catalyst. The py‐CB/Co3O4 composite catalyst is highly competitive compared to other carbon‐based catalysts, owing to its high activity, excellent stability, and especially the use of inexpensive CB and the ease of preparation. This work may open a new avenue for the design and preparation of ORR catalysts based on cheap and commercially available CB.
Alpha‐ and Beta‐Diastereoisomers of Phenylcobalamin from Cobalt‐Arylation with Diphenyliodonium Chloride
Authors: Brenig Christopher , Ruetz Markus , Kieninger Christoph , Wurst Klaus , Kräutler Bernhard 
Published: May 2017

AbstractOrganometallic aryl‐cobalamins are B12‐derivatives featuring properties of potential ‘B12 antivitamins’. Herein, we describe a new method for the preparation of aryl‐cobalamins using versatile diaryliodonium salts as arylation agents. Formate or sodium borohydride reduction of aquocobalamin in presence of diphenyliodonium chloride furnished Coβ‐phenyl‐cobalamin PhCbl in a roughly 3:1 to 1:1 ratio with its coordination isomer αPhCbl, a first representative ‘base‐off’ Coα‐aryl‐cobalamin. The new structures were secured by detailed spectroscopic analysis, supplemented by an X‐ray crystal structure analysis of PhCbl. Both types of coordination isomers of the aryl‐cobalamins promise to be useful molecular tools in biomedical and biological studies.
Uniform Yolk–Shell MoS2@Carbon Microsphere Anodes for High‐Performance Lithium‐Ion Batteries
Authors: Pan Yunmei , Zhang Jiajia , Lu Hongbin 
Published: May 2017

AbstractAs an electrode material for lithium‐ion batteries (LIBs), MoS2 has attracted much attention because of its high capacity and low cost. However, the rational design of a novel electrode structure with a high capacity, fast charge/discharge rate, and long cycling lifetime remains a great challenge. Herein, a environmentally friendly etching strategy is reported for the construction of monodisperse, inner void‐controlled yolk–shell MoS2@carbon microspheres. The resulting anode reveals an initial discharge capacity up to 1813 mAh g−1, a high reversible capacity (1016 mAh g−1), excellent cycling stability (200 cycles), and superior rate performance. Such microspheres consist of nanosized MoS2 yolks (≈280 nm), porous carbon shells (≈25 nm) and well‐controlled internal voids in between, opening a new pathway for the optimization of the electrochemical properties of MoS2‐based anodes without sacrificing their capacity. In addition, this etching strategy offers a new method for the development of functional, hollow MoS2‐based composites.
α‐Quaternary Mannich Bases through Copper‐Catalyzed Amination‐Induced 1,2‐Rearrangement of Allylic Alcohols
Authors: Weng Wei‐Zhi , Sun Jian‐Guo , Li Ping , Zhang Bo 
Published: May 2017

AbstractA novel copper‐catalyzed amination‐induced 1,2‐rearrangement reaction of allylic alcohols has been developed under simple and mild conditions. The commercially available N‐fluorobenzenesulfonimide (NFSI) is employed as an amination reagent. In this transformation, not only alkyl, but also aryl substituents can efficiently undergo 1,2‐carbon atom migration, thereby providing an efficient and powerful route to prepare a wide range of α‐quaternary Mannich bases. The reaction features a broad substrate scope, operational simplicity, and excellent practicality.
Adaptive parallel Delaunay triangulation construction with dynamic pruned binary tree model in Cloud
Authors: Lin Jiaxiang , Chen Riqing , Wu Liping , Shu Zhaogang , Yang Changcai 
Published: May 2017

SummaryThe paper illustrates a parallel and distributed scheme for computing a planar Delaunay triangulation using a divide‐and‐conquer strategy in Cloud environment, which combines the incremental insertion algorithm and the divide‐and‐conquer method. The proposed hybrid algorithm for Delaunay triangulation construction is easy to be parallelized due to the dynamic pruned characteristic of the binary tree model used. Moreover, the Cloud platform decreases the communication overhead and improves data locality by making use of a data partitioning and integrating scheme offered by the map‐reduce architecture. The implementation of the parallel and distributed version of the algorithm relied on a robust data structure called quad‐edge, which implies the geometric relationship among the edges and vertexes adjacent. More importantly, the data are serialized easily and transmitted efficiently between different Cloud nodes; the algorithm is executed conveniently on PC clusters. We tested the parallel version of the algorithm on GeoKSCloud, a geographical knowledge service Cloud developed by our research team. Experimental results show that the proposed hybrid algorithm is efficient and competitive; it can be easily migrated and deployed in distributed and parallel computing environment, such as grid and Cloud. The parallel implementation of the hybrid algorithm has a good speed‐up, while data communication is the crucial factor for the efficiency of the parallel version. Overall, the parallel version outperforms both the sequential divide‐and‐conquer algorithm and the sequential incremental insertion algorithm.
The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study
Authors: Roth Roswith , Baxter Judith , Vehik Kendra , Hopkins Diane , Killian Michael , Gesualdo Patricia , Melin Jessica , Simell Barbara , Strauss Elisabeth , Lernmark Åke , Johnson Suzanne Bennett ,   The TEDDY Study Group
Published: May 2017

AbstractSaliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre‐ and post‐blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non‐invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.
Physiological functioning moderates infants’ sensory sensitivity in higher conflict families
Authors: Mammen Micah A. , Busuito Alex , Moore Ginger A. , Quigley Kelsey M. , Doheny Kim Kopenhaver 
Published: May 2017

AbstractChildren exposed to parent conflict may be at risk for emotional and behavioral disorders by becoming sensitized to conflict cues in their environments. This study explored possible precursors to negative child outcomes associated with parent conflict by examining the relation between parent conflict and infants’ (N = 36; 23–42 weeks; 44% female) behavioral sensitivity to general sensory stimuli (e.g., loud noises, physical touch). To determine whether infants’ characteristic autonomic arousal and regulation moderated this association, infant baseline skin conductance (SC) and respiratory sinus arrhythmia (RSA) were measured. Parents reported levels of parent conflict, and mothers reported infants’ behavioral sensory sensitivity. The association between parent conflict and lower threshold for sensory sensitivity was strongest for infants with higher physiological arousal (higher SC) and lesser capacity for physiological regulation (lower RSA). Children may become more sensitive to environmental stimuli as a function of parent conflict during infancy, though this appears to depend on characteristic physiological arousal and regulation.
Of beta diversity, variance, evenness, and dissimilarity
Authors: Ricotta Carlo 
Published: May 2017

AbstractThe amount of variation in species composition among sampling units or beta diversity has become a primary tool for connecting the spatial structure of species assemblages to ecological processes. Many different measures of beta diversity have been developed. Among them, the total variance in the community composition matrix has been proposed as a single‐number estimate of beta diversity. In this study, I first show that this measure summarizes the compositional variation among sampling units after nonlinear transformation of species abundances. Therefore, it is not always adequate for estimating beta diversity. Next, I propose an alternative approach for calculating beta diversity in which variance is substituted by a weighted measure of concentration (i.e., an inverse measure of evenness). The relationship between this new measure of beta diversity and so‐called multiple‐site dissimilarity measures is also discussed.