bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Catalyst‐Controlled Switch of Regioselectivity in the Asymmetric Allylic Alkylation of Oxazolones with MBHCs.
Authors: Zhu Gongming , Yang Junxian , Bao Guangjun , Zhang Ming , Li Jing , Li Yiping , Sun Wangsheng , Hong Liang , Wang Rui 
Published: November 2016

AbstractThe SN2′—SN2′reaction catalyzed by a quinine‐derived base produces γ‐selective secondary allylic oxazolone derivatives, whereas the addition—elimination reaction catalyzed by an amino acid‐derived bifunctional urea catalyst provides β‐selective primary adducts.
ChemInform Abstract: FeF3‐Catalyzed MCR in PEG‐400: Ultrasound Assisted Synthesis of N‐Substituted 2‐Aminopyridines.
Authors: Kumar Reddy Dinne Naresh , Chandrasekhar Kothapalli Bannoth , Siva Ganesh Yaddanapudi Sesha , Reddy G. Rajeshwar , Kumar J. Pradeep , Kapavarapu Ravi Kumar , Pal Manojit 
Published: November 2016

AbstractA novel one‐pot synthesis of highly functionalized pyridines is accomplished by an ultrasound assisted multi‐component reaction.
ChemInform Abstract: Cp*CoIII‐Catalyzed C(sp3)—H Bond Amidation of 8‐Methylquinoline.
Authors: Barsu Nagaraju , Rahman Md. Atiur , Sen Malay , Sundararaju Basker 
Published: November 2016

AbstractVarious title compounds are treated with oxazolones in the absence of any external oxidant.
ChemInform Abstract: Potassium tert‐Butoxide‐Promoted Synthesis of 1‐Aminoisoquinolines from 2‐Methylbenzonitriles and Benzonitriles under Catalyst‐Free Conditions.
Authors: Feng Jian‐Bo , Wu Xiao‐Feng 
Published: November 2016

AbstractThe method affords various substituted isoquinolines in different yields.
ChemInform Abstract: N,N‐Dimethylacetamide (DMA) as a Methylene Synthon for Regioselective Linkage of Imidazo[1,2‐a]pyridine.
Authors: Modi Anju , Ali Wajid , Patel Bhisma K. 
Published: November 2016

AbstractDMA (II) serves as methylene source and solvent in the process which provides a series of heterocyclic dimers required in medicinal and material chemistry.
ChemInform Abstract: A Concise Synthesis of Quinolinium, and Biquinolinium Salts and Biquinolines from Benzylic Azides and Alkenes Promoted by Copper(II) Species.
Authors: Chen Wei‐Chen , Gandeepan Parthasarathy , Tsai Chia‐Hung , Luo Ching‐Zong , Rajamalli Pachaiyappan , Cheng Chien‐Hong 
Published: November 2016

AbstractThe reaction probably proceeds through a Lewis acidic CuII‐assisted rearrangement of benzylic azide to N‐methylaniline, followed by a [4+2] cycloaddition with alkene.
ChemInform Abstract: Oxidative Radical Addition—Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis.
Authors: Zhong Xingren , Lv Jian , Luo Sanzhong 
Published: November 2016

AbstractThe scalable title reaction offers access to tetrahydropyridazines from N‐tosylhydrazones and styrenes, including 1,1‐disubstituted derivatives, as well as alkyl alkenes and cyclopentadiene.
ChemInform Abstract: Synthesis of Substituted 4‐, 5‐, 6‐, and 7‐Azaindoles from Aminopyridines via a Cascade C—N Cross‐Coupling/Heck Reaction.
Authors: Pires Marina J. D. , Poeira Diogo L. , Purificacao Sara I. , Marques M. Manuel B. 
Published: November 2016

AbstractThe procedure represents the first approach to all four azaindole isomers via cascade C‐N cross‐coupling/Heck reaction.
ChemInform Abstract: A Choline Hydroxide Catalyzed Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones in an Aqueous Medium.
Authors: Borase Pravin N. , Thale Pranila B. , Shankarling G. S. 
Published: November 2016

AbstractCholin hydroxide is found to be a clean, recyclable (up to 6 times) and green catalyst for the synthesis of the title compounds from 2‐aminobenzonitriles and aldehydes.
ChemInform Abstract: Dihydrooxazine N‐Oxide Intermediates as Resting States in Organocatalytic Kinetic Resolution of Functionalized Nitroallylic Amines with Aldehydes.
Authors: Gurubrahamam Ramani , Chen Yan Ming , Huang Wan‐Yun , Chan Yu‐Te , Chang Hsiang‐Kai , Tsai Ming‐Kang , Chen Kwunmin 
Published: November 2016

AbstractFurther hydrolysis of the title intermediates provides tetrahydropyridines in high yields and with high diastereo‐ and enantioselectivities.
ChemInform Abstract: Copper‐Catalyzed Regio and Diastereoselective Three Component C—N, C—C and C—O Bond Forming Reaction: Oxidative sp3 C—H Functionalization.
Authors: Gupta Kankatala S. V. , Ramana Daggupati V. , Vinayak Botla , Sridhar Balasubramanian , Chandrasekharam Malapaka 
Published: November 2016

Abstract21 Tetrahydroisoquinoline derivatives of type (IV) or (VII) are prepared by a one‐pot three‐component reaction comprising the formation of a C—N, a C—C and a C—O bond.
ChemInform Abstract: Sodium Chlorate as a Viable Substoichiometric Oxidant for Cobalt‐Catalyzed Oxidative Annulation of Aryl Sulfonamides with Alkynes.
Authors: Ran You , Yang Yudong , Zhang Luoqiang 
Published: November 2016

AbstractFor the first time, NaClO3 is demonstrated to be a versatile oxidant in the catalytic C—H activation of N‐(8‐quinolyl) substituted sulfonamides which react with alkynes to give sultams in good yields.
ChemInform Abstract: Site‐Selective Aliphatic C—H Silylation of 2‐Alkyloxazolines Catalyzed by Ruthenium Complexes.
Authors: Kon Kazumasa , Suzuki Hiroyuki , Takada Kosuke , Kohari Yoshihito , Namikoshi Takeshi , Watanabe Shinji , Murata Miki 
Published: November 2016

AbstractSome heterocyclic substrates, substituted at the ortho‐position of a heteroatom with alkyl substituents bearing a site‐selective methyl group, are successfully silylated with reagent (II).
ChemInform Abstract: Natural‐Antioxidant‐Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity.
Authors: Paegle Edgars , Domracheva Ilona , Turovska Baiba , Petrova Marina , Kanepe‐Lapsa Iveta , Gulbe Anita , Liepinsh Edvards , Arsenyan Pavel 
Published: November 2016

AbstractCyclization of fluorinated arylalkynes (I) under selenobromination conditions affords the required precursors (II).
ChemInform Abstract: Stereoselective Koenigs—Knorr Glycosylation Catalyzed by Urea.
Authors: Sun Lifeng , Wu Xiaowei , Xiong De‐Cai , Ye Xin‐Shan 
Published: November 2016

AbstractA stereoselective Koenigs—Knorr glycosylation reaction under the catalysis of urea is described.
ChemInform Abstract: Hyperhexanone A, a Crucial Intermediate from Bicyclo[3.3.1]‐ to Cyclohexanone Monocyclic‐Polycyclic Polyprenylated Acylphloroglucinols.
Authors: Zhu Hucheng , Chen Chunmei , Yang Jing , Li Dongyan , Zhang Jinwen , Guo Yi , Wang Jianping , Luo Zengwei , Xue Yongbo , Zhang Yonghui 
Published: November 2016

AbstractTwo novel polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives Hyperhexanone A (I) and B (II) are isolated from Hypericum sampsonii.
ChemInform Abstract: Cold Sintering: A Paradigm Shift for Processing and Integration of Ceramics.
Authors: Guo Jing , Guo Hanzheng , Baker Amanda L. , Lanagan Michael T. , Kupp Elizabeth R. , Messing Gary L. , Randall Clive A. 
Published: November 2016

AbstractA new sintering technique (cold sintering) for ceramics and ceramic‐based composites using water as a transient solvent to effect densification at temperatures between room temperature and 200 °C is described.
ChemInform Abstract: Multifunctional Polymetallaynes: Properties, Functions and Applications
Authors: Ho Cheuk‐Lam , Yu Zhen‐Qiang , Wong Wai‐Yeung 
Published: November 2016

AbstractReview: [structure‐property‐function relationships of the title metallopolymers and their emerging applications in electronic, optical and magnetic devices; 101 refs.
Modulation of the Polymerization Kinetics of α/β‐Tubulin by Osmolytes and Macromolecular Crowding
Authors: Schummel Paul Hendrik , Gao Mimi , Winter Roland 
Published: November 2016

AbstractTubulin is one of the main components of the cytoskeleton and can be found in nearly all eukaryotic cells. In this study, we explored the effects of kosmotropic and chaotropic osmolytes, such as trimethylamine‐N‐oxide (TMAO) and the metabolic waste product urea, as well as the crowding agents Ficoll and sucrose on the polymerization reaction of α/β‐tubulin. Time‐dependent turbidimetry and fluorescence anisotropy experiments were performed to explore the kinetics of the polymerization reaction. Under different solvent conditions, diverse changes in the lag time, the half‐life of the polymerization reaction, and the critical concentration of the polymerization reaction were observed. The apparent growth rate of the formation of microtubules was dramatically decreased in the presence of urea but significantly increased in the presence of TMAO. Measurements using mixtures of these two cosolvents showed that TMAO was able to counteract the deteriorating effect of urea on the polymerization reaction of tubulin. To create a more cell‐like environment, Ficoll was added as a macromolecular crowding agent. The presence of 10 wt % Ficoll increased the apparent growth rate by one order of magnitude. Our results clearly show that the polymerization of tubulin is very sensitive to the surrounding solvent.
Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties
Authors: Musumeci Domenica , Roviello Giovanni N. , Rigione Giuseppina , Capasso Domenica , Di Gaetano Sonia , Riccardi Claudia , Roviello Valentina , Montesarchio Daniela 
Published: November 2016

AbstractTo further explore the properties and bioactivity of benzodifurans, three compounds in this class were synthesised and characterised using spectroscopic and spectrometric techniques, as well as SEM and thermogravimetric analysis. The synthesised compounds showed interesting antiproliferative activity on different human cancer cells (HeLa, Hep‐G2, WM266), whereas no relevant cytotoxic effect was observed on healthy control cells. To study the possible mechanism of action of the benzodifurans, their ability to bind various model DNA systems, their aggregation properties, and their ability to bind biologically relevant metal ions was evaluated. The molecules were found to form monodisperse nanoaggregates stable at physiological temperature, which are likely related to the observed bioactivity.
Lowstand wedges in carbonate platform slopes (Quaternary, Maldives, Indian Ocean)
Authors: Betzler Christian , Hübscher Christian , Lindhorst Sebastian , Lüdmann Thomas , Reijmer John J. G. , Braga Juan‐Carlos 
Published: November 2016

AbstractSeismic, hydroacoustic and sedimentological data were used to analyse the response of atoll‐slope sedimentation in the Maldives to the late Quaternary sea‐level change. The slope deposits, as imaged in multichannel seismic profiles, are arranged into stacked aggrading to backstepping basinward thinning wedges. In a piston core recovered at the lower slope of one of the atolls, the sediment texture ranges from packstone to rudstone. Major components are blackened bioclasts, the large benthic foraminifers Operculina and Amphistegina, together with Halimeda debris and red algae. Radiocarbon dating at a core depth of 66 cm indicates that the wedge sedimentation stopped or was largely reduced after 16 ka BP. Therefore, the atoll‐slope deposits largely consist of sediment formed in situ and deposited during the last glacial lowstand in sea‐level. This is in apparent contradiction to the concept of highstand shedding of tropical carbonate platforms, which requires slope sedimentation during sea‐level highstands, when the platform is flooded. Rather than intrinsic factors, such as sediment bypass along the steep slope, the extrinsic process of current winnowing of the slope appears to be a major controlling factor in the production of this feature. This process may be relevant for other case studies of carbonate platforms, as currents may be accelerated around such edifices, leading to slope winnowing and sediment deposition in more current‐protected zones. The study results also have consequences for the interpretation of outcrop and seismic subsurface data of carbonate platform slope series, because such slope sediment wedges are not necessarily formed during sea‐level highstands, but can consist of lowstand wedges only.
Running during adolescence rescues a maternal separation‐induced memory impairment in female mice: Potential role of differential exon‐specific BDNF expression
Authors: Wearick‐Silva Luis Eduardo , Marshall Paul , Viola Thiago Wendt , Centeno‐Silva Anderson , de Azeredo Lucas Araújo , Orso Rodrigo , Li Xiang , Donadio Márcio V. , Bredy Timothy W. , Grassi‐Oliveira Rodrigo 
Published: November 2016

AbstractExposure to early life stress has been associated with memory impairments related to changes in brain‐derived neurotrophic factor (BDNF) signaling. However, the potential impact of physical exercise to reverse these effects of maternal separation has been under investigated. Mice were subjected to maternal separation during the first 2 weeks of life and then exposed to a 3‐week running protocol during adolescence. The spontaneous object recognition task was performed during adolescence followed by analysis of hippocampal expression of exons I, IV, and IX of the BDNF gene. As expected, maternal separation impaired recognition memory and this effect was reversed by exercise. In addition, running increased BDNF exon I expression, but decreased expression of BDNF exon IV in all groups, while exon IX expression increased only in MS animals exposed to exercise. Our data suggest that memory deficits can be attenuated by exercise and specific transcripts of the BDNF gene are dynamically regulated following both MS and exercise.
Screen‐printed Tattoo Sensor towards the Non‐invasive Assessment of the Skin Barrier
Authors: De Guzman Keana , Morrin Aoife 
Published: November 2016

AbstractThe development and characterisation of a screen‐printed tattoo sensor for the non‐invasive assessment of the skin barrier is presented. A screen‐printed silver tattoo sensor comprising two concentric circle electrodes was fabricated and applied and characterised initially on a soft tissue mimic. It was shown that the tattoo was capable of tracking changes in water content in the soft tissue mimic using impedance spectroscopy. The tattoo sensors were then applied to porcine and human skins and impedance spectroscopy was used to interrogate the skin at the outer stratum corneum (SC). The SC is a layer of great interest from a dermatological point of view since it plays a critical role in the barrier function of the skin by protecting underlying tissue from infection, dehydration, chemical irritants and mechanical stress. Hydration changes were tracked in the skin using the impedance approach and validated against a tissue dielectric constant (TDC) measurement taken with the MoistureMeterD (MMD, Delfin Technologies). The impedimetric results obtained using the tattoo sensor were modelled into proposed circuit models representative of the systems measured. From this study, the potential of using wearable tattoo electrodes coupled with impedance spectroscopy as a transduction technique, to investigate skin barrier status offers considerable promise towards the monitoring and self‐management of skin health.
Tuning the Composition of PdCuNi Hollow Nanospheres for Low Cost and Efficient Catalyst Towards Glycol Electrooxidation
Authors: Hong Wei , Shang Changshuai , Wang Jin , Wang Erkang 
Published: November 2016

AbstractIn this research, we reported an effective approach to prepare low cost and efficient electrocatalyst for the glycol electrooxidation. The synthetic process involves the replacement reactions between CuCl2/H2PdCl4 and Ni nanospheres template. Through controlling the precursor ratio, the Pd/Cu/Ni ratio of the final trimetallic products can be tuned. The prepared electrocatalysts present a monodispersed nanospheres structure with a hollow cavity. The prepared Pd41Cu27Ni9 shows the best catalytic activity (0.021 A cm−2 at 0.9 V vs. RHE) for glycol electrooxidation, which is much higher than that of the commercial Pd/C (0.0014 A cm−2 at 0.9 V vs. RHE).
Additive toxicity of zinc and arsenate on barley (Hordeum vulgare) root elongation
Authors: Guzmán-Rangel Georgina , Versieren Liske , Qiu Hao , Smolders Erik 
Published: November 2016

Abstract

Zinc (Zn) and arsenic (As) are typically present as mixed contaminants in mining-impacted areas; however, their joined effects have rarely been evaluated. The present study was set up to test whether the Zn2+ and H2AsO4– (hereafter, As) mixture toxicity to plants is additive or whether interactions occur. Barley (Hordeum vulgare) root elongation was measured in resin buffered nutrient solutions. The design included ranges of single-element concentrations and combinations at 3 different Ca2+ concentrations (0.5 mM, 2.2 mM, and 15.0 mM) to vary the relative toxicity of Zn2+. Increasing Ca concentrations decreased Zn toxicity, whereas As toxicity was unaffected by Ca. Root elongation was generally more affected in Zn–As mixtures than in corresponding single-element treatments. This is merely a joint additive effect, as 96% of the root elongation data were within a factor of 1.2 from predictions using the independent action (IA) or concentration addition (CA) model. The CA and IA predictions were similar, and data did not allow identification of equal or dissimilar modes of action. Small but significant Zn–As antagonisms were only found at high effects (&gt;50% inhibition). The present study suggests that mixture effects of Zn and As are environmentally relevant and that current risk assessment underestimates toxicity in multielement-contaminated environments. The CA model can be used as a conservative model for risk assessment; however, for soil-grown plants, soil-exposed studies are needed. Environ Toxicol Chem 2017;36:1556–1562. © 2016 SETAC
Moderating risk of Alzheimer's disease through the use of anxiolytic agents
Authors: Burke Shanna L. , O'Driscoll Janice , Alcide Amary , Li Tan 
Published: November 2016

ObjectivesAnxiety diagnoses occur in 17.1% in people age 65 years and older. Individuals with anxiety may be at a higher risk of the development of probable Alzheimer's disease (AD). Previous literature has suggested that anxiolytic medications may exacerbate the risk of AD development. This study explored anxiolytic medication as a potential moderator of AD risk in older adults.MethodsA secondary data analysis of the National Alzheimer's Coordinating Center Uniform Data Set was undertaken, analyzing observations from 12,083 participants with normal cognition at the first visit. Survival analysis was utilized to examine if anxiolytic medication use by those with anxiety and/or APOE ɛ4 moderates the hazard of AD and/or MCI development.ResultsThe hazard of probable AD (HR = 3.50, [2.77 – 4.44], p < .0001) or MCI (HR = 2.13, [1.85–2.44], p < .0001) development was statistically significant for those with anxiety. This hazard was no longer statistically significant when specific anxiolytics were used. ɛ4 carriers experienced a statistically significant hazard of AD (HR = 1.92, [1.52–2.41], p < .001) and MCI (HR = 1.17, [1.04–1.32], p < .05) development. This effect was moderated by the use of anxiolytics.DiscussionThe results of this study suggest that anxiolytics may moderate the effect of anxiety on MCI and AD development, specifically indicating a neutralized hazard for those with ɛ4 carriers with anxiety. Copyright © 2016 John Wiley & Sons, Ltd.
Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase‐2 (TPH2) polymorphism
Authors: Han Kyu‐Man , Won Eunsoo , Kang June , Kim Aram , Yoon Ho‐Kyoung , Chang Hun Soo , Son Kyu Ri , Lee Min‐Soo , Tae Woo‐Suk , Ham Byung‐Joo 
Published: November 2016

AbstractThe tryptophan hydroxylase‐2 (TPH2) gene is considered a promising genetic candidate regarding its association with a predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with theTPH2rs4570625 polymorphism in patients with MDD. One hundred and thirteen patients with MDD and eighty‐six healthy controls underwent T1‐weighted structural magnetic resonance imaging and genotyping forTPH2rs4570625. The local gyrification index of 22 cortical regions in the prefrontal cortex and anterior cingulate cortex was analyzed using the FreeSurfer. The patients with MDD showed significant hypergyria in the right rostral anterior cingulate cortex (P = 0.001), medial orbitofrontal cortex (P = 0.003), and frontal pole (P = 0.001). There was a significant genotype‐by‐diagnosis interaction for the local gyrification index in the right rostral anterior cingulate cortex (P = 0.003). Their study revealed significant hypergyria of the anterior cingulate cortex and prefrontal cortex and an interactive effect between the diagnosis of MDD and the genotype in the anterior cingulate cortex. This might be associated with the dysfunction of neural circuits mediating emotion processing, which could contribute to pathophysiology of MDD.Hum Brain Mapp 38:1299–1310, 2017. © 2016 Wiley Periodicals, Inc.
Developmental differences in cognitive control of social information
Authors: Marotta Andrea , Casagrande Maria 
Published: November 2016

AbstractWe investigated developmental differences in the ability to exert cognitive control in the context of distracting spatial cues varying in social significance. Adults and children (6–13 years) were asked to classify target words (LEFT/RIGHT) that were accompanied by a distracter arrow or averted gaze pointing in a direction that was congruent, incongruent, or neutral (bar without arrowheads, central gaze) relative to the target word. Results showed that interference from averted eye‐gaze differed between adults and children indicating that cognitive control of social information improves with age. These age differences did not generalize to the interference effect from arrows. On the basis of these findings, it was concluded that adults are better at inhibiting and/or to ignore another person's distracting gaze than are children.Highlights

We examined the developmental differences in the ability to exert cognitive control on social and non‐social directional information
Evidence of age‐related differences in the inhibitory control of attention was only observed with social eye‐gaze distracters
Inhibitory mechanisms of social attention continue to improve along development
From Roquefortine C to Roquefortine L: Formation of a Complex Nitrone with Simple Oxidizing Agents
Authors: Gober Claire M. , Joullié Madeleine M. 
Published: November 2016

AbstractThe oxidation of roquefortine C to the nitrone roquefortine L was investigated using a number of different electrophilic oxidizing reagents. mCPBA and Oxone were shown to be the most effective in achieving this transformation, while unfavorable steric interactions precluded oxidation by bulky reagents such as Davis oxaziridine. Finally, each of the oxidants was shown to promote aromatic hydroxylation following the synthesis of the nitrone functionality.