bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcortical or intracondylar? Which model is accurate for predicting biomaterial attachment in total joint replacement?
Authors: Bloebaum Roy D. , Abdo Nicole T. , Hofmann Aaron A. , Epperson Richard T. , Olsen Raymond E. , Chalayon Ornusa 
Published: February 2017

AbstractDespite four decades of research on material and porous coatings intended for cementless fixation in total joint replacement (TJR), aseptic mechanical loosening unrelated to particulate disease remains a concern. One main question asked is how translational are the animal models used to screen material and porous coatings intended for TJR fixation? Another question is how specific are the translational models at targeting the cementless TJR components that have the highest loosening rates? The hypothesis tested was that the bone response would be different between the two bone types—cortical and cancellous—used in translational animal modeling. The osteoblastic jumping distance (OJD), percent ingrowth, and appositional bone response were measured to assess the response between cancellous and cortical bone at two different anatomical locations, within the same limb. With 500 µm inset, titanium porous coated implants and negative control dinosaur (coprolite) implants were investigated. The data demonstrated that cortical bone had 7 times OJD than cancellous bone. The bone ingrowth data demonstrated 16 times higher bone ingrowth than the cancellous bone. Light microscopy showed predominately fibrous tissue attachment (98%) in cancellous bone. Screening of materials intended for TJR require a translational model predictive of the clinical condition. The results demonstrated that the transcortical model rendered false‐positive data. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 578–588, 2018.
Hemorrhagic metalloproteinase, Cc HSM‐III, isolated from Cerastes cerastes venom: Purification and biochemical characterization
Authors: Tachoua Wafa , Boukhalfa‐Abib Hinda , Laraba‐Djebari Fatima 
Published: February 2017

AbstractSnake venom metalloproteinases are the most abundant toxins in Viperidae venoms. In this study, a new hemorrhagin, Cc HSM‐III (66 kDa), was purified from Cerastes cerastes venom by gel filtration, ion exchange, and reversed‐phase high‐performance liquid chromatographies. The analysis of Cc HSM‐III by liquid chromatography with a tandem mass spectrometry revealed 32 peptides sharing a homology with P‐III metalloproteinases from Echis ocellatus snake venom. Cc HSM‐III displays hemorrhagic activity with a minimal hemorrhagic dose of 5 μg, which is abolished by ethylene diamine tetracetic acid but not by phenylmethylsulfonyl fluoride. The mechanism underlying Cc HSM‐III hemorrhagic activity is probably due to its extensive proteolytic activity against type IV collagen. Cc HSM‐III induces local tissue damage and an inflammatory response by upregulating both matrix metalloproteinase 2 and 9 in skin of mice. Thus, Cc HSM‐III may play a key role in the pathogenesis of C. cerastes envenomation.
Iron deficiency anemia interfering the diagnosis of compound heterozygosity for Hb constant spring and Hb Paksé: The first case report
Authors: Chiasakul Thita , Uaprasert Noppacharn 
Published: February 2017

BackgroundDiagnosis of thalassemia or hemoglobinopathy concomitant with iron deficiency anemia (IDA) is challenging.MethodWe report a case of 43‐year‐old female whose diagnosis of compound heterozygosity for hemoglobin Constant Spring (HbCS) and Hb Paksé became apparent after the treatment of IDA.ResultsPrior to treatment, Hb analysis using isoelectric focusing (IEF) showed HbA 95.6%, HbA2 2.7%, and HbCS 1.7% compatible with heterozygous HbCS. After 4 months of oral iron therapy resulting in an improved Hb level, her HbCS level was substantially increased to 8.7% on IEF suggesting homozygous HbCS. Subsequent DNA analysis using multiplex amplification refractory mutation system analysis revealed compound heterozygosity for HbCS and Hb Paksé.ConclusionThis case demonstrated that IDA can significantly reduce HbCS/Hb Paksé levels and probably mask the diagnosis of homozygous HbCS, homozygous Hb Paksé or the compound heterozygosity for both hemoglobinopathies by hemoblogin analysis. The test should be repeated after resolution of IDA, or molecular testing should be performed to confirm the diagnosis.
Electrocatalysis enhancement of a screen‐printed carbon electrode by modification with trisoctahedral gold nanocrystals for H2O2 and NADH sensing application
Authors: Liu Yu‐Cheng , Su Yu‐Ming , Chen Kuan‐Jung , Huang Wei‐Chen , Kuo Yu‐Lin , Lin Shawn D 
Published: February 2017

AbstractBACKGROUNDNoblemetal nanocrystals with high index facets have received much attention because of their enhanced catalytic performance. This paper describes the trisoctahedral gold nanocrystals (TOH Au NCs) with {441} high‐index facets for the modification of a screen printed carbon electrode.RESULTSTOH Au NCs enclosed high index facets provided high sensitivity as well as detecting H2O2 and NADH with a lower detection limit of 0.05 mmol L−1 at a signal‐to‐noise ratio of 3. The values of sensitivity for the disposable electrochemical sensors to H2O2 and NADH were calculated to be 11.1 and 0.74 μA mmol L−1 cm2 at the working potentials of −0.2 and 0.2 V, respectively. In particular, the extremely small loading amount of TOH Au NCs (5.12 × 10−5 g cm−2) shows unusually high sensing performance for the electrochemical reactions of H2O2 and NADH.CONCLUSIONSOur discovery of the reaction mechanism in TOH Au NCs provides a new understanding of the interaction in Au‐modified disposable electrochemical sensors, and gives a new way to control the interaction between gold and the support as well as electrocatalytic activities. Thus, TOH Au NCs as electrocatalyst can offer quite promising signal transduction in the disposable electrochemical sensors for biological and environmental application. © 2017 Society of Chemical Industry
Morphology and nanoindentation properties of mouthparts in Cyrtotrachelus longimanus (Coleoptera: curculionidae)
Authors: Li Longhai , Guo Ce , Xu Shun , Li Xin , Han Cheng 
Published: February 2017

AbstractMicrostructure and nanoindentation properties of the mouthparts for the skillful driller Cyrtotrachelus longimanus are presented. The composition and morphological examinations are made using light, fluorescent, scanning electron microscopy, and Energy Disperse Spectroscopy, respectively. Nanoindentation was carried out to measure the elastic modulus and the hardness of mouthparts. The hardness and modulus for “dry” samples is 0.202 ± 0.065 and 8.604 ± 0.838 GPa, respectively, and the values of “fresh” ones is 0.126 ± 0.0196 and 6.951 ± 0.065 GPa, respectively. These results are critical for analyze the drilling mechanism of the weevil and provide a biological template to inspire the biomimetic design.
Light manipulation in organic light‐emitting devices by integrating micro/nano patterns
Authors: Feng Jing , Liu Yue‐Feng , Bi Yan‐Gang , Sun Hong‐Bo 
Published: February 2017

AbstractThe demonstration of high efficiency and color tunability has brought organic light‐emitting devices (OLEDs) into the lighting and display market. High efficiency is one of the key issues for their commercial applications, for which much effort has been devoted to developing novel materials and device structures. It is well known that around 80% of the generated photons are trapped in OLED structure, so that there is still the greatest scope for significant improvements in its efficiency. This has driven the research towards the integration of micro/nano patterns into device structures that benefit from their abilities in manipulating the generation and propagation of photons. Micro/nano patterns with random or periodic morphologies have demonstrated their effect on the outcoupling of the trapped photons within the device. Moreover, the emitting properties other than the light extraction could be manipulated by introducing the micro/nano patterns. This article reviews the recent progresses in improving the light extraction and manipulating the emission properties of the OLEDs through the introduction of the micro/nano patterns by various fabrication strategies. The light manipulation of the micro/nano patterns in organic photovoltaics is briefly discussed considering its similar working principle and fabrication strategies to that of the OLEDs.image
On analyticity of the ‐Stokes semigroup for some non‐Helmholtz domains
Authors: Bolkart Martin , Giga Yoshikazu , Miura Tatsu‐Hiko , Suzuki Takuya , Tsutsui Yohei 
Published: February 2017

AbstractConsider the Stokes equations in a sector‐like C3 domain . It is shown that the Stokes operator generates an analytic semigroup in for . This includes domains where the ‐Helmholtz decomposition fails to hold. To show our result we interpolate results of the Stokes semigroup in and L2 by constructing a suitable non‐Helmholtz projection to solenoidal spaces.
Confocal laser scanning, scanning electron, and transmission electron microscopy investigation of Enterococcus faecalis biofilm degradation using passive and active sodium hypochlorite irrigation within a simulated root canal model
Authors: Mohmmed Saifalarab A. , Vianna Morgana E. , Penny Matthew R. , Hilton Stephen T. , Mordan Nicola , Knowles Jonathan C. 
Published: February 2017

AbstractRoot canal irrigation is an important adjunct to control microbial infection. The aim of this study was to investigate the effect of 2.5% (wt/vol) sodium hypochlorite (NaOCl) agitation on the removal, killing, and degradation of Enterococcus faecalis biofilm. A total of 45 root canal models were manufactured using 3D printing with each model comprising an 18 mm length simulated root canal of apical size 30 and taper 0.06. E. faecalis biofilms were grown on the apical 3 mm of the models for 10 days. A total of 60 s of 9 ml of 2.5% NaOCl irrigation using syringe and needle was performed, the irrigant was either left stagnant in the canal or agitated using manual (Gutta‐percha), sonic, and ultrasonic methods for 30 s. Following irrigation, the residual biofilms were observed using confocal laser scanning, scanning electron, and transmission electron microscopy. The data were analyzed using one‐way ANOVA with Dunnett post hoc tests at a level of significance p ≤ .05. Consequence of root canal irrigation indicate that the reduction in the amount of biofilm achieved with the active irrigation groups (manual, sonic, and ultrasonic) was significantly greater when compared with the passive and untreated groups (p < .05). Collectively, finding indicate that passive irrigation exhibited more residual biofilm on the model surface than irrigant agitated by manual or automated (sonic, ultrasonic) methods. Total biofilm degradation and nonviable cells were associated with the ultrasonic group.
Model‐based denoising in diffusion‐weighted imaging using generalized spherical deconvolution
Authors: Sperl Jonathan I. , Sprenger Tim , Tan Ek T. , Menzel Marion I. , Hardy Christopher J. , Marinelli Luca 
Published: February 2017

PurposeDiffusion MRI often suffers from low signal‐to‐noise ratio, especially for high b‐values. This work proposes a model‐based denoising technique to address this limitation.MethodsA generalization of the multi‐shell spherical deconvolution model using a Richardson‐Lucy algorithm is applied to noisy data. The reconstructed coefficients are then used in the forward model to compute denoised diffusion‐weighted images (DWIs). The proposed method operates in the diffusion space and thus is complementary to image‐based denoising methods.ResultsWe demonstrate improved image quality on the DWIs themselves, maps of neurite orientation dispersion and density imaging, and diffusional kurtosis imaging (DKI), as well as reduced spurious peaks in deterministic tractography. For DKI in particular, we observe up to 50% error reduction and demonstrate high image quality using just 30 DWIs. This corresponds to greater than fourfold reduction in scan time if compared to the widely used 140‐DWI acquisitions. We also confirm consistent performance in pathological data sets, namely in white matter lesions of a multiple sclerosis patient.ConclusionThe proposed denoising technique termed generalized spherical deconvolution has the potential of significantly improving image quality in diffusion MRI. Magn Reson Med 78:2428–2438, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
Phosphodiester content measured in human liver by in vivo 31P MR spectroscopy at 7 tesla
Authors: Purvis Lucian A.B. , Clarke William T. , Valkovič Ladislav , Levick Christina , Pavlides Michael , Barnes Eleanor , Cobbold Jeremy F. , Robson Matthew D. , Rodgers Christopher T. 
Published: February 2017

PurposePhosphorus (31P) metabolites are emerging liver disease biomarkers. Of particular interest are phosphomonoester and phosphodiester (PDE) “peaks” that comprise multiple overlapping resonances in 31P spectra. This study investigates the effect of improved spectral resolution at 7 Tesla (T) on quantifying hepatic metabolites in cirrhosis.MethodsFive volunteers were scanned to determine metabolite T1s. Ten volunteers and 11 patients with liver cirrhosis were scanned at 7T. Liver spectra were acquired in 28 min using a 16‐channel 31P array and 3D chemical shift imaging. Concentrations were calculated using γ‐adenosine‐triphosphate (γ‐ATP) = 2.65 mmol/L wet tissue.ResultsT1 means ± standard deviations: phosphatidylcholine 1.05 ± 0.28 s, nicotinamide‐adenine‐dinucleotide (NAD+) 2.0 ± 1.0 s, uridine‐diphosphoglucose (UDPG) 3.3 ± 1.4 s. Concentrations in healthy volunteers: α‐ATP 2.74 ± 0.11 mmol/L wet tissue, inorganic phosphate 2.23 ± 0.20 mmol/L wet tissue, glycerophosphocholine 2.34 ± 0.46 mmol/L wet tissue, glycerophosphoethanolamine 1.50 ± 0.28 mmol/L wet tissue, phosphocholine 1.06 ± 0.16 mmol/L wet tissue, phosphoethanolamine 0.77 ± 0.14 mmol/L wet tissue, NAD+ 2.37 ± 0.14 mmol/L wet tissue, UDPG 2.00 ± 0.22 mmol/L wet tissue, phosphatidylcholine 1.38 ± 0.31 mmol/L wet tissue. Inorganic phosphate and phosphatidylcholine concentrations were significantly lower in patients; glycerophosphoethanolamine concentrations were significantly higher (P < 0.05).ConclusionWe report human in vivo hepatic T1s for phosphatidylcholine, NAD+, and UDPG for the first time at 7T. Our protocol allows high signal‐to‐noise, repeatable measurement of metabolite concentrations in human liver. The splitting of PDE into its constituent peaks at 7T may allow more insight into changes in metabolism. Magn Reson Med 78:2095–2105, 2017. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
3D phase contrast MRI: Partial volume correction for robust blood flow quantification in small intracranial vessels
Authors: Bouillot Pierre , Delattre Bénédicte M. A. , Brina Olivier , Ouared Rafik , Farhat Mohamed , Chnafa Christophe , Steinman David A. , Lovblad Karl‐Olof , Pereira Vitor M. , Vargas Maria I. 
Published: February 2017

PurposeRecent advances in 3D‐PCMRI (phase contrast MRI) sequences allow for measuring the complex hemodynamics in cerebral arteries. However, the small size of these vessels vs spatial resolution can lead to non‐negligible partial volume artifacts, which must be taken into account when computing blood flow rates. For this purpose, we combined the velocity information provided by 3D‐PCMRI with vessel geometry measured with 3DTOF (time of flight MRI) or 3DRA (3D rotational angiography) to correct the partial volume effects in flow rate assessments.MethodsThe proposed methodology was first tested in vitro on cylindrical and patient specific vessels subject to fully controlled pulsatile flows. Both 2D‐ and 3D‐PCMRI measurements using various spatial resolutions ranging from 20 to 1.3 voxels per vessel diameter were analyzed and compared with flowmeter baseline. Second, 3DTOF, 2D‐ and 3D‐PCMRI measurements were performed in vivo on 35 patients harboring internal carotid artery (ICA) aneurysms indicated for endovascular treatments requiring 3DRA imaging.ResultsThe in vitro 2D‐ and 3D‐PCMRI mean flow rates assessed with partial volume correction showed very low sensitivity to the acquisition resolution above
voxels per vessel diameter while uncorrected flow rates deviated critically when decreasing the spatial resolution. 3D‐PCMRI flow rates measured in vivo in ICA agreed very well with 2D‐PCMRI data and a good flow conservation was observed at the C7 bifurcation. Globally, partial volume correction led to 10–15% lower flow rates than uncorrected values as those reported in most of the published studies on intracranial flows.ConclusionPartial volume correction may improve the accuracy of PCMRI flow rate measurements especially in small vessels such as intracranial arteries. Magn Reson Med 79:129–140, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Influence of genetic variants associated with body mass index on eating behavior in childhood
Authors: Monnereau Claire , Jansen Pauline W. , Tiemeier Henning , Jaddoe Vincent W.V. , Felix Janine F. 
Published: February 2017

ObjectiveChildhood eating behaviors are associated with body mass index (BMI). Recent genome‐wide association studies have identified many single‐nucleotide polymorphisms (SNPs) associated with adult and childhood BMI. This study hypothesized that these SNPs also influence eating behavior.MethodsIn a population‐based prospective cohort study among 3,031 children (mean age [standard deviation]: 4.0 [0.1] years), two weighted genetic risk scores, based on 15 childhood and 97 adult BMI SNPs, and ten individual appetite‐ and/or satiety‐related SNPs were tested for association with food fussiness, food responsiveness, enjoyment of food, satiety responsiveness, and slowness in eating.ResultsThe 15 SNP‐based childhood BMI genetic risk score was not associated with the eating behavior subscales. The 97 SNP‐based adult BMI genetic risk score was nominally associated with satiety responsiveness (β: −0.007 standard deviation, 95% confidence interval [CI] −0.013, 0.000). Of the 10 individual SNPs, rs11030104 in BDNF and rs10733682 in LMX1B were nominally associated with satiety responsiveness (β: −0.057 standard deviation, 95% CI −0.112, −0.002).ConclusionsThese findings do not strongly support the hypothesis that BMI‐associated SNPs also influence eating behavior at this age. A potential role for BMI SNPs in satiety responsiveness during childhood was observed; however, no associations with the other eating behavior subscales were found.
Plasma asparaginase activity, asparagine concentration, and toxicity after administration of Erwinia asparaginase in children and young adults with acute lymphoblastic leukemia: Phase I/II clinical trial in Japan
Authors: Ogawa Chitose , Taguchi Fumi , Goto Hiroaki , Koh Katsuyoshi , Tomizawa Daisuke , Ohara Akira , Manabe Atsushi 
Published: February 2017

AbstractBackgroundA phase I/II study of Erwinia asparaginase in Japanese children and young adults with acute lymphoblastic leukemia (ALL) was performed to investigate its activity and toxicity.ProcedureEligible patients were in remission and had developed allergy to Escherichia coli asparaginase. Erwina asparaginase was intramuscularly administrated on days 2, 5, 7, 9, 11, and 13. To measure the plasma l‐asparagine concentration (PAC), amino acids were derivatized with Nα‐(5‐fluoro‐2,4‐dinitrophenyl)‐l‐leucinamide.ResultsSix consecutive patients completed the phase I study with 25,000 IU/m2 per dose without dose‐limiting toxicity and 18 patients completed the phase II study with 25,000 IU/m2 per dose. Median age of 24 patients was 7.5 (range 2–16) years. The half‐life of plasma asparaginase activity (PAA) was 16.9 ± 7.5 hr and the maximum PAA was 3.10 ± 1.47 IU/ml (n = 23, noncompartment model). PAA of 0.1 IU/ml or more was achieved in all 23 patients (100%) 48 hr and in 18 of 23 patients (78.3%) 72 hr after the first administration. During the 2‐week study, 94.2% (65 of 69) of the 48‐hr samples and 80.4% (37 of 46) of the 72‐hr samples had PAA of 0.1 IU/ml or more. PAC less than 1.0 μM was achieved in 95.7% patients 48 and 72 hr after administration. PAC values in all the samples were greater than the limit of quantitation (0.0625 μM). Karnofsky performance status of all patients was good during the 2‐week study.ConclusionsErwinia asparaginase 25,000 IU/m2 per dose × six intramuscular administrations in 2 weeks was well tolerated, pharmacologically efficacious, and safe in Japanese patients with ALL/lymphoblastic lymphoma.
Poly(lactic acid) plasticized with low‐molecular‐weight polyesters: structural, thermal and biodegradability features
Authors: Cicogna Francesca , Coiai Serena , De Monte Cristina , Spiniello Roberto , Fiori Stefano , Franceschi Massimiliano , Braca Francesca , Cinelli Patrizia , Fehri Seyed Mohammad Kazem , Lazzeri Andrea , Oberhauser Werner , Passaglia Elisa 
Published: February 2017

AbstractPoly(lactic acid) (PLA) was plasticized with ester oligomers having different structure, molecular weight and carboxylic acid content as end‐functionalities. In particular PLA oligomers and a low‐molecular‐weight polyester of adipic acid and 1,2‐propanediol (an adipate‐based derivative) were used and compared. The plasticizing capability was tested and the final structural and thermal properties of PLA matrix were evaluated by correlating the various features to the chemical and physical characteristics of these additives. SEC, DSC, TGA, tensile tests, XRD and SEM results, even after annealing, were collected, and the related data analysed and evaluated with reference to additive starting properties. All the oligoesters were able to generate flexible compounds, but PLA oligomers provided mixtures with reduced structural and thermal stability. Finally, the best performing blend was tested for biodegradability to definitely assess the material suitability for the final application (sustainable packaging). © 2017 Society of Chemical Industry
Continuous output‐feedback control for a class of switched high‐order planar systems and its application
Authors: Liu Liang , Xie Xue‐Jun 
Published: February 2017

SummaryThis paper deals with the problem of continuous output‐feedback stabilization for a class of switched high‐order planar systems under arbitrary switchings. Based on the common Lyapunov function design method, by using the adding a power integrator technique and designing an implementable observer, a continuous output‐feedback controller is constructed such that the closed‐loop system is global stabilization and the output can be regulated to the origin. As an application, the developed strategy is utilized to the control design for the continuous stirred tank reactor with two modes feed stream. The simulation results verify the efficiency of the proposed design scheme. Copyright © 2017 John Wiley & Sons, Ltd.