bluuebunny/crossref_metadata_2025_split huggingface dataset:
The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis
Authors: Biedermann Sascha , Harashima Hirofumi , Chen Poyu , Heese Maren , Bouyer Daniel , Sofroni Kostika , Schnittger Arp 
Published: March 2017

AbstractThe retinoblastoma protein (Rb), which typically functions as a transcriptional repressor of E2F‐regulated genes, represents a major control hub of the cell cycle. Here, we show that loss of the Arabidopsis Rb homolog RETINOBLASTOMA‐RELATED 1 (RBR1) leads to cell death, especially upon exposure to genotoxic drugs such as the environmental toxin aluminum. While cell death can be suppressed by reduced cell‐proliferation rates, rbr1 mutant cells exhibit elevated levels of DNA lesions, indicating a direct role of RBR1 in the DNA‐damage response (DDR). Consistent with its role as a transcriptional repressor, we find that RBR1 directly binds to and represses key DDR genes such as RADIATION SENSITIVE 51 (RAD51), leaving it unclear why rbr1 mutants are hypersensitive to DNA damage. However, we find that RBR1 is also required for RAD51 localization to DNA lesions. We further show that RBR1 is itself targeted to DNA break sites in a CDKB1 activity‐dependent manner and partially co‐localizes with RAD51 at damage sites. Taken together, these results implicate RBR1 in the assembly of DNA‐bound repair complexes, in addition to its canonical function as a transcriptional regulator.
Hypoxia enhances antibody‐dependent dengue virus infection
Authors: Gan Esther Shuyi , Cheong Wei Fun , Chan Kuan Rong , Ong Eugenia Ziying , Chai Xiaoran , Tan Hwee Cheng , Ghosh Sujoy , Wenk Markus R , Ooi Eng Eong 
Published: March 2017

AbstractDengue virus (DENV) has been found to replicate in lymphoid organs such as the lymph nodes, spleen, and liver in post‐mortem analysis. These organs are known to have low oxygen levels (~0.5–4.5% O2) due to the vascular anatomy. However, how physiologically low levels of oxygen affect DENV infection via hypoxia‐induced changes in the immune response remains unknown. Here, we show that monocytes adapted to 3% O2 show greater susceptibility to antibody‐dependent enhancement of DENV infection. Low oxygen level induces HIF1α‐dependent upregulation of fragment crystallizable gamma receptor IIA (FcγRIIA) as well as HIF1α‐independent alterations in membrane ether lipid concentrations. The increased FcγRIIA expression operates synergistically with altered membrane composition, possibly through increase membrane fluidity, to increase uptake of DENV immune complexes for enhanced infection. Our findings thus indicate that the increased viral burden associated with secondary DENV infection is antibody‐dependent but hypoxia‐induced and suggest a role for targeting hypoxia‐induced factors for anti‐dengue therapy.
Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy
Authors: Lee You‐Kyung , Jun Yong‐Woo , Choi Ha‐Eun , Huh Yang Hoon , Kaang Bong‐Kiun , Jang Deok‐Jin , Lee Jin‐A 
Published: March 2017

AbstractMacroautophagy allows for bulk degradation of cytosolic components in lysosomes. Overexpression of GFP/RFP‐LC3/GABARAP is commonly used to monitor autophagosomes, a hallmark of autophagy, despite artifacts related to their overexpression. Here, we developed new sensors that detect endogenous LC3/GABARAP proteins at the autophagosome using an LC3‐interacting region (LIR) and a short hydrophobic domain (HyD). Among HyD‐LIR‐GFP sensors harboring LIR motifs of 34 known LC3‐binding proteins, HyD‐LIR(TP)‐GFP using the LIR motif from TP53INP2 allowed detection of all LC3/GABARAPs‐positive autophagosomes. However, HyD‐LIR(TP)‐GFP preferentially localized to GABARAP/GABARAPL1‐positive autophagosomes in a LIR‐dependent manner. In contrast, HyD‐LIR(Fy)‐GFP using the LIR motif from FYCO1 specifically detected LC3A/B‐positive autophagosomes. HyD‐LIR(TP)‐GFP and HyD‐LIR(Fy)‐GFP efficiently localized to autophagosomes in the presence of endogenous LC3/GABARAP levels and without affecting autophagic flux. Both sensors also efficiently localized to MitoTracker‐positive damaged mitochondria upon mitophagy induction. HyD‐LIR(TP)‐GFP allowed live‐imaging of dynamic autophagosomes upon autophagy induction. These novel autophagosome sensors can thus be widely used in autophagy research.
El capital social y el incremento en la oferta de cursos de idiomas en la Universidad de Costa Rica: experiencias del curso Catalán Básico I
Authors: Blanco Obando Edgar Eduardo 
Published: March 2017

Este artículo presenta la apertura del curso Catalán Básico I en la Escuela de Lenguas Modernas (ELM) de la Universidad de Costa Rica (UCR), como resultado del capital social generado dentro de la misma Universidad. A su vez, propone crear espacios y fomentar la participación solidaria de los universitarios para obtener mayores proyectos de beneficio público y bien común. This article presents the course Catalan Basic I of the School of Modern Languages at the University of Costa Rica, as a result of university’s social capital. At the same time, it aims to promote academic’s voluntary work to increase projects of common good.
Árvores urbanas: técnicas não-destrutivas para o manejo e planejamento
Authors: Sales Almir , Candian Marcela 
Published: March 2017

As árvores são importantes equipamentos da infra-estrutura urbana, tanto pela necessidade da presença da natureza nas cidades, como pelo conforto proporcionado pelo sombreamento e melhoria da qualidade de vida. O presente trabalho objetivou obter parâmetros para a aplicação da técnica não-destrutiva por meio de ondas de tensão para o manejo de árvores urbanas sem a necessidade de provocar destruição do lenho ou corte prematuro. Foram selecionadas doze árvores da espécie Caesalpinea peltophoroides localizadas em vias públicas, nas quais foram realizados ensaios com a técnica de ondas de tensão, os quais permitiram a produção de imagens tomográficas. Os resultados permitiram verificar que a técnica de ondas de tensão apresenta viabilidade de aplicação na avaliação interna de árvores urbanas e , que esta técnica pode ser utilizada para balizar o serviços de manejo e evitar cortes indevidos das árvores urbanas.
Aplikasi MATLAB untuk Mengenali Karakter Tulisan Tangan
Authors: Mahmudi Ali 
Published: March 2017

<p>Handwriting recognition is one of the very interesting research object in the field of image processing, artificial intelligence and computer vision. This is due to the handwritten characters is varied in every individual. The style, size and orientation of handwriting characters has made every body’s is different, hence handwriting recognition is a very interesting research object. Handwriting recognition application has been used in quite many applications, such as reading the bank deposits, reading the postal code in letters, and helping peolple in managing documents.</p><p>This paper presents a handwriting recognition application using Matlab. Matlab toolbox that is used in this research are Image Processing and Neural Network Toolbox.</p><p> </p>
Penerapan Metode Tutor Sebaya dalam Meningkatkan Hasil Belajar Kognitif Siswa Kelas XI SMA ABC Yogyakarta pada Topik Sistem Gerak [The Implementation of Peer Tutoring to Increase Cognitive Achievment about the Movement System for Grade XI Students at SMA ABC]
Authors: Da Lopez Marshelly Christyanna , Purba Zein Mario , Indriani Siane 
Published: March 2017

<p>Based on low student test scores in a grade XI science class at ABC Senior High School in Yogyakarta, the observer found that the students had difficulties understanding the Movement System. This happened because the learning process in the classroom focused on the teacher and was monotone in nature so the instructional objective was not reached as proven by the low test results. Based on this problem, the observer planned and designed a peer tutor learning process to increase the students' cognitive results. The observer used Classroom Action Research which went from October 20, 2015 to October 29, 2015. There were two cycles that involved 22 students. The instruments used were test sheets, student feedback sheets, observation sheets, mentor interviews with the observer, and the observer’s journal reflections. In the process of analyzing the instruments, the observer used simple mathematic calculations and qualitative analysis techniques. The research showed that the students’ cognitive level (knowledge) increased from 77.27% to 86.36% and the cognitive level (understanding) increased from 63.64% to 90.9% which suggests that cognitive learning can be increased through the implementation of peer tutoring learning method. </p><p class="Default"><em><em>BAHASA INDONESIA ABSTRAK:</em> Dari hasil tes siswa XI MIPA di SMA ABC Yogyakarta, peneliti menemukan siswa kesulitan dalam mengerjakan tes yang diberikan sehingga berdampak pada rendahnya hasil belajar kognitif siswa. Hal ini dikarenakan kegiatan pembelajaran di dalam kelas yang berpusat pada guru dan berjalan monoton sehingga tujuan instruksional tidak tercapai yang dibuktikan dengan hasil tes yang rendah. Berdasarkan permasalahan ini, peneliti merencanakan dan merancang metode tutor sebaya dalam pembelajaran. Hal ini ditujukan untuk melihat peningkatan hasil belajar kognitif siswa. Peneliti menggunakan metode Penelitian Tindakan Kelas yang dilakukan sejak 15 Oktober 2015 hingga 29 Oktober 2015. Penelitian yang dilaksanakan berlangsung sebanyak dua siklus dengan melibatkan 22 siswa. Instrumen yang digunakan dalam penelitian ini adalah lembar tes, lembar kusioner siswa, lembar observasi dan wawancara mentor dan rekan sejawat serta jurnal refleksi peneliti. Dalam menganalisis instrumen tersebut, peneliti menggunakan penghitungan matematika sederhana dan analisis secara kualitatif deskriptif. Dari hasil penelitian, diperoleh peningkatan kognitif pada level mengetahui dari 77,27% menjadi 86,36% dan peningkatan kognitif dari 63,64% menjadi 90,9% pada level memahami dalam materi Sistem Gerak sehingga dapat disimpulkan bahwa hasil belajar kognitif dapat ditingkatkan melalui penerapan metode pembelajaran tutor sebaya.</em></p><p><em> </em></p>
Police Brutality and Black Health: Setting the Agenda for Public Health Scholars
Authors: Alang Sirry , McAlpine Donna , McCreedy Ellen , Hardeman Rachel 
Published: March 2017

We investigated links between police brutality and poor health outcomes among Blacks and identified five intersecting pathways: (1) fatal injuries that increase population-specific mortality rates; (2) adverse physiological responses that increase morbidity; (3) racist public reactions that cause stress; (4) arrests, incarcerations, and legal, medical, and funeral bills that cause financial strain; and (5) integrated oppressive structures that cause systematic disempowerment.Public health scholars should champion efforts to implement surveillance of police brutality and press funders to support research to understand the experiences of people faced with police brutality. We must ask whether our own research, teaching, and service are intentionally antiracist and challenge the institutions we work in to ask the same.To reduce racial health inequities, public health scholars must rigorously explore the relationship between police brutality and health, and advocate policies that address racist oppression.
New Results on Multiple Solutions for Intuitionistic Fuzzy Differential Equations
Authors: Wang Lei , Guo Sicong 
Published: March 2017

AbstractThe first-order fuzzy differential equations with intuitionistic fuzzy initial valued problem is studied. Firstly, with the help of (α, β)-cut set, the distance metric and the Hukuhara difference between intuitionistic fuzzy numbers are defined, and on this basis the concept of differentiability for the intuitionistic fuzzy number-valued functions is defined and a corresponding theorem is derived. Then, according to the selection of derivative the first order intuitionistic fuzzy differential equations is interpreted. Finally, an example of first-order linear intuitionistic fuzzy differential equations is solved, and the results show that there are four different solutions.
Особливості виникнення та перебігу електролітних порушень в гострий період інсульту у хворих на цукровий діабет
Authors: Halushko O.A. 
Published: March 2017

Актуальність. Електролітні порушення, що виникають у хворих на гострий інсульт (ГІ), є однією з причин ускладнень перебігу ГІ. Супутній цукровий діабет (ЦД) впливає на тяжкість перебігу інсульту та збільшує показники летальності. Мета дослідження: дослідити частоту, особливості розвитку та лікування електролітних порушень у хворих на ГІ на фоні супутнього ЦД. Матеріали та методи. Проведений ретроспективний аналіз лікування 416 пацієнтів із ГІ, яких розподілили на три групи: 1) хворі зі встановленим до початку інсульту ЦД; 2) хворі з уперше виявленим ЦД; 3) хворі без ЦД. Другим етапом було проведено пілотне дослідження з аналізом частоти порушень обміну магнію і фосфатів у хворих на ГІ (20 хворих на ГІ на фоні ЦД та 10 хворих на ГІ без ЦД). Результати. Серед 416 хворих на ГІ в анамнезі був наявний ЦД у 110 пацієнтів (26,4 %), ще у 48 хворих (11,5 %) діагноз ЦД був встановлений уперше. Таким чином, частота виявлення ЦД у хворих на ГІ становила майже 38,0 %, що набагато вище, ніж у відповідній віковій популяції. Загалом різні види електролітних порушень спостерігалися у 258 із 349 (73,9 %) пацієнтів з ГІ, при цьому у хворих із розладами вуглеводного обміну ці порушення виникали вірогідно частіше, ніж у хворих без таких. Гіпомагніємія (< 0,8 ммоль/л) спостерігалася у 2 з 10 хворих (20 %) на ГІ без вуглеводних порушень та у 6 з 20 хворих (30 %) на ГІ із супутнім ЦД. Гіпофосфатемія (< 0,8 ммоль/л) не була виявлена у хворих на ГІ без ЦД та лише у 2 хворих на ГІ із супутнім ЦД. Висновки. У разі розвитку ГІ на фоні ЦД електролітні порушення виникають вірогідно частіше, ніж у хворих без такої коморбідної патології. Потрібні подальші дослідження для з’ясування ролі окремих електролітних розладів (зокрема, магнію і фосфатів) у перебігу і наслідках ГІ.
A report detailing the development of a university-based knowledge mobilization unit that enhances research outreach and engagement
Authors: Phipps David 
Published: March 2017

This field note presents reflections from the perspective of a knowledge mobilization (KMb) practitioner after 5 years of developing and delivering KMb services in a university-based environment. This field note is a “how to” based on experience from the field of KMb practice and places that experience in the context of academic literature. The paper concludes that KMb is not a single event or process but a system, a suite of services that work together to support the multi-directional connection of researchers with decision makers. The six KMb services that comprise the KMb system are informed by four broad KMb methods: producer push, user pull, knowledge exchange and co-production. Examples of each KMb service are provided along with key observations that allow others interested in developing institutional KMb support services to implement these services in their own context. The field note concludes with clear recommendations for individuals and organizations interested in developing their own system of KMb services.
Beyond Remediation: The Role of Textual Studies in Implementing New Knowledge Environments
Authors: Galey Alan , Cunningham Richard , Nelson Brent , Siemens Ray , Werstine Paul 
Published: March 2017

This article considers the role of textual studies in a digital world and reviews the work of a particular group of digital textual scholars. Specifically, the article examines the work of the Textual Studies team at the Implementing New Knowledge Environments project (INKE.ca), a group of digital textual scholars working on user experience, interface design, and information management with the goal of better understanding how reading is changing in the context of digital media. INKE’s work rethinks what the book can become and aims to generate prototypes to be shared on an open-source basis with the public.
E-readers are for Reading: An Informal Consideration of Reading’s Next Steps
Authors: Kircz Joost 
Published: March 2017

The e-reader is sweeping the book and library world like a storm, with some theorists arguing that the end of the publisher, the end of the library, and even the end of the book are near. Do e-readers bring an end to literacy as we now know it, or are there avenues of inquiry we can use to engage this change in a more positive light? To begin to answer this pressing question, this article presents an informal survey of a series of pertinent issues that have to be tackled before making such decisive predictions.
The NT2 Hypermedia Art and Literature Directory: A New Knowledge Environment Devoted to the Valorization of Screen Culture
Authors: Gervais Bertrand 
Published: March 2017

In the shift from book to screen culture, the production and transmission of culture, and its literary and artistic manifestations, have changed. With the emergence of new technologies, these literary and artistic works are meant to be read or experienced using the Internet; yet, there is a lack of bibliographical, or other substantial listing, to preserve these works. This article considers the attempt of the NT2 Laboratory to fill this void through the creation of the Hypermedia Art and Literature Directory, which aims to promote studying, reading, creating and archiving new forms of text and works in hypermedia.
Beyond Open Access to Open Publication and Open Scholarship
Authors: Maxwell John W 
Published: March 2017

This article explores a moment of opportunity to imagine a new humanities scholarship based on radical openness, beyond the level of access to scholarly content that the open access movement has so far championed, to a culture of transformation that can actively include the public(s) beyond the community of scholars. The possibilities for enhancing scholarly and research practices are intriguing, but even greater may be the generative opportunity to engage audiences beyond the scholarly community – particularly online, where the humanities connects to broader cultural currents.
Insulin and Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Maiorino Maria Ida , Chiodini Paolo , Bellastella Giuseppe , Capuano Annalisa , Esposito Katherine , Giugliano Dario 
Published: March 2017

OBJECTIVE
The combination of basal insulin plus a glucagon-like peptide 1 receptor agonist (GLP-1RA) has been proposed as a treatment option to intensify insulin therapy in type 2 diabetes. We performed a meta-analysis of randomized controlled trials (RCTs) comparing this combination strategy to other injectable antidiabetes treatments on metabolic control in adult patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
We conducted an electronic search until November 2016 on many electronic databases to identify RCTs assessing changes in HbA1c, proportion of patients at HbA1c target ≤7% (53 mmol/mol), hypoglycemia, and weight change. We used a random-effect model to calculate the weighted mean difference (WMD) or relative risk (RR) with the 95% CI.

RESULTS
We identified 26 RCTs, lasting 12–52 weeks, and involving 11,425 patients. When the combination strategy was compared with other injectable treatments (overall data), there were reductions in HbA1c (WMD = −0.47%, 95% CI −0.59 to −0.35), more patients at HbA1c target (RR = 1.65, 95% CI 1.44–1.88), similar hypoglycemic events (RR = 1.14, 95% CI 0.93–1.39) and a reduction in weight (WMD = −2.5 kg, 95% CI −3.3 to −1.7), with high heterogeneity (I2 &gt; 89%, P &lt; 0.001) and a significant publication bias for three outcomes. In preplanned subgroup analyses, the combination treatment was similar to basal-bolus insulin regimens for glycemic control, with less hypoglycemia (RR = 0.66, 95% CI 0.46–0.93) and reduced weight (WMD = −4.7 kg, 95% CI −6.9 to −2.4). Fixed-ratio combinations yielded results similar to the overall analysis (HbA1c WMD = −0.56%, 95% CI −0.72 to −0.40).

CONCLUSIONS
GLP-1RAs alone or as titratable fixed-ratio combinations with basal insulin may represent a promising option to advance basal insulin therapy or to initiate injectable therapy in patients with type 2 diabetes inadequately controlled on oral agents. Longer studies are needed to assess durability and tolerability.
PEMANFAATAN KULIT BAWANG MERAH SEBAGAI PEWARNA KAIN DENGAN TEKNIK JUMPUTAN MENGGUNAKAN MORDAN TAWAS, KAPUR, DAN TUNJUNG
Authors: Diah Angendari Made 
Published: March 2017

Penelitian ini bertujuan untuk mengetahui: (1) hasil pewarnaan kain dengan teknik jumputan menggunakan zat warna kulit bawang tanpa proses mordating, (2) perbedaan hasil jadi pewarnaan kain teknik jumputan dengan kulit bawang merah dengan modan tawas, kapur, dan tunjung, (3) hasil jadi pewarnaan kain teknik jumputan dengan kulit bawang merah yang paling disukai antara menggunakan mordan tawas, kapur, dan tunjung.Jenis penelitian ini adalah penelitian eksperimen. Uji kualitas meliputi penilaian ketuaan warna dan tingkat kesukaan panelis. Peneliti menggunakan pengujian mutu hedonik, yaitu panelis diminta tanggapan tentang kesukaan produk hasil eksperimen. Analisis deskriptif untuk mengetahui gambaran tentang data yang diperoleh yaitu ketuaan warna. Uji statistik digunakan untuk menguji hipotesis. Hasil penelitian adalah sebagai berikut: (1) Kulit bawang merah dapat digunakan sebagai bahan pewarna kain dengan teknik jumputan tanpa proses mordating. (2) Ada perbedaan hasil jadi pewarnaan kain teknik jumputan dengan kulit bawang merah dengan menggunakan mordan tawas, kapur, dan tunjung, tawas menghasilkan warna yang lebih muda, kapur sedang dan tunjung warna tua (3) Hasil jadi pewarnaan kain teknik jumputan dengan kulit bawang merah yang paling disukai antara menggunakan mordan tawas, kapur, dan tunjung adalah yang menggunakan mordan tawas.
CONTRADICTIONS ECONOMIC GROWTH& INVESTOR EXIT IN INDONESIA
Authors: Hendriyani Chandra 
Published: March 2017

Slowing global economic growth and a decline in the level of trust business institutions in the Euro Area and the United Kingdom to Indonesia contributed to an economic slowdown in Indonesia. Although economic growth in Indonesia alone to increase, but it can not support the climate of the industry that is conducive and increasing purchasing power, as is still needed "invisible hand" of the government to minimize the "Transaction Cost" and "Relational Contract" and wages rill employees decreased resulting in decreased demand society to product processing industry which led to the departure of some foreign companies in Indonesia. The government's economic policy issued gradually expected to accelerate Indonesia out of the "vicious circle" both economic slowdown and improve Indonesia's competitiveness, in order to spur national economic growth and a better investment. Government policy hope will support company to make their business sustainable
PARTNERSHIP PROGRAM SYSTEM TROUGHT SI BULE ALBINO INSTITUTIONAL BUSINESS BY MINE FIRM IN BINUANG DISTRICT KAB. TAPIN
Authors: Khamdan Ali 
Published: March 2017

This research explains how the partnerships system built between the comunnities arround the mine with coal mining company. Citizens fostered independence catfish farm business trought programs binuang original catfish farming system (si Bule Albinoe), the company manages CSR citizens trought funds managed by LPB Baprida. This study used descriptive qualitative approach, data are obtained primarily trought interviews with the target group, secondary data obtained from LPB Baprida. The result showed ; 1) system partnership undertaken by the company has been very precisely so as to increase income of farmers catfish. 2). a huge market demand of the catfish into opprtunities by catfish farmers in the cultivation development. 3). expand the marketing network of catfish up to the modern market. 4) in the development catfish farming is often monopolized by midlemen so that advantage by catfish farmers againt reduced. This may affect the interest of farmers in developing catfish, but the market demand for the development of this very large catfish.