bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in seed dormancy associated with the domestication ofCucurbita maxima: elucidation of some mechanisms behind this response
Authors: Martínez Analía B. , Lema Verónica , Capparelli Aylen , López Anido Fernando , Benech-Arnold Roberto , Bartoli Carlos G. 
Published: December 2017

AbstractThis work presents the results of physiological studies developed to understand modifications linked to the reduction of seed dormancy provoked by domestication processes. The experiments performed compared wild and domesticatedCucurbitasubspecies and their hybrids developed by reciprocal crossings. Seeds of two accessions of the wild subspecies presented dormancy, but it was largely reduced in seeds from the domesticated genotype, and partially reverted in hybrids, especially in those obtained when the domesticated genotype was used as the mother plant. In addition, naked embryos of all subspecies did not display dormancy when incubation was performed at 28°C, but embryo germination was progressively reduced only in the wild genotype under decreasing incubation temperatures (22 and 16°C). In the embryos, abscisic acid (ABA) concentrations were similar in both domesticated and wild subspecies, whereas in the seed coat, it was threefold higher in the wild subspecies. The naked embryos from the wild subspecies were far more responsive to ABA than those from the domesticated subspecies. These results indicate that dormancy in the wild subspecies is imposed by the seed coat tissues and that this effect is mediated by their high ABA content and the sensitivity of the embryos to ABA. These physiological aspects were apparently removed by domestication along with the temperature-dependent response for germination.
Sen, justice and the private realm of dispute resolution
Authors: De Girolamo Debbie 
Published: December 2017

AbstractThe attainment of justice through a private dispute-resolution process, such as the mediation process, is an elusive objective. With the prominent place mediation has been given in civil justice, debates about the ability of mediation to deliver substantive justice are relevant, particularly when proponents of the process argue that mediation offers some form of justice to its participants, while critics argue that it provides no justice. This paper explores the issue of justice in the private dispute-resolution process of mediation and its ability to deliver a substantive form of justice (rather than procedural or popular justice, which is often seen as the type of justice, if any, that is provided by mediation). It does so through an analysis of ethnographic data of the mediation process using Amartya Sen's justice framework set out inThe Idea of Justice.
Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics
Authors: Wang Liping , Jang Grace , Ban Deependra Kumar , Sant Vrinda , Seth Jay , Kazmi Sami , Patel Nirav , Yang Qingqing , Lee Joon , Janetanakit Woraphong , Wang Shanshan , Head Brian P , Glinsky Gennadi , Lal Ratneshwar 
Published: December 2017

AbstractMulti-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P(NIPAM-co-MAA) to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in: (a) a glass capillary tube to simulate their delivery via blood vessels; and (b) porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood–brain barrier (BBB). The viscoelastic properties of hydrogels were examined by atomic force microscopy (AFM). Cellular uptake of DOX-loaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells (iPSCs) as well as epithelial HeLa cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells’ viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and epithelial cells even though the drug release efficiency was higher in neurons. Therefore, development of smart nanoshuttles have significant translational potential for controlled delivery of theranostics’ payloads and precisely guided transport in specified tissues and organs (for example, bone, cartilage, tendon, bone marrow, heart, lung, liver, kidney, and brain) for highly efficient personalized medicine applications.
Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway
Authors: Wang Wenping , Li Pei , Xu Jiagang , Wu Xiangkun , Guo Zhiliang , Fan Lijing , Song Ruipeng , Wang Jianli , Wei Li , Teng Haijun 
Published: December 2017

Background: Diabetes mellitus is closely correlated with disc degeneration. Nucleus pulposus (NP) cell apoptosis and senescence are typical cellular features within the degenerative disc. Resveratrol is a newly identified phytoalexin that has protective effects on cartilaginous tissue.
Objective: To investigate the whether resveratrol can protect against high glucose-induced NP cell apoptosis and senescence, and the potential mechanism in this process.
Methods: Rat NP cells were cultured in either 10% FBS culture medium (control group) or 10% FBS with a high glucose concentration (0.2 M, experiment group) for 3 days. Resveratrol or the combination of resveratrol and LY294002 was added into the culture medium of experiment group to investigate the effects of resveratrol and the PI3K/Akt pathway.
Results: High glucose significantly promoted NP cell apoptosis and NP cell senescence compared with the control group. Resveratrol exhibited protective effects against high glucose-induced NP cell apoptosis and senescence. Further analysis showed that resveratrol suppressed reactive oxygen species (ROS) generation and increased the activity of the PI3K/Akt pathway under the high glucose condition. However, the LY294002 had no significant effects on ROS content in the resveratrol-treated high glucose group.
Conclusion: Resveratrol can attenuate high glucose-induced NP cell apoptosis and senescence, and the activation of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.
Modelling and control of a VSC medium‐voltage DC distribution network with DFIG wind farm
Authors: Patrobers Simiyu , Ai Xin , Teshager Bitew Girmaw , Kunyu Wang 
Published: December 2017

The voltage source converters (VSC) medium‐voltage DC (MVDC) is the future distribution network for integrating renewable energy sources. The doubly fed induction generator (DFIG) wind turbine is the most efficient option for wind farm application. The intermittency of wind power is challenging in grid integration at the AC distribution system level. This study presents a ±10 kV VSC MVDC network with DFIG wind farm integrated to mitigate these effect. Key MVDC network components and controllers are modelled including the control strategy for the MVDC grid. The proposed system is validated in MATLAB/SIMULINK for steady state and transient conditions. The results show that the MVDC can work as firewall that absorbs the fluctuating wind power to a stable system with good power flow and balance as well as constant DC voltage. Therefore, the MVDC network is a stable system with fast dynamic response.
Seismic probing of the first dredge-up event through the eccentric red-giant and red-giant spectroscopic binary KIC 9163796
Authors: Beck P. G. , Kallinger T. , Pavlovski K. , Palacios A. , Tkachenko A. , Mathis S. , García R. A. , Corsaro E. , Johnston C. , Mosser B. , Ceillier T. , do Nascimento J.-D. , Raskin G. 
Published: December 2017

Context.Binaries in double-lined spectroscopic systems (SB2) provide a homogeneous set of stars. Differences of parameters, such as age or initial conditions, which otherwise would have strong impact on the stellar evolution, can be neglected. The observed differences are determined by the difference in stellar mass between the two components. The mass ratio can be determined with much higher accuracy than the actual stellar mass.Aim.In this work, we aim to study the eccentric binary system KIC 9163796, whose two components are very close in mass and both are low-luminosity red-giant stars.Methods.We analysed four years ofKeplerspace photometry and we obtained high-resolution spectroscopy with theHermesinstrument. The orbital elements and the spectra of both components were determined using spectral disentangling methods. The effective temperatures, and metallicities were extracted from disentangled spectra of the two stars. Mass and radius of the primary were determined through asteroseismology. The surface rotation period of the primary is determined from theKeplerlight curve. From representative theoretical models of the star, we derived the internal rotational gradient, while for a grid of models, the measured lithium abundance is compared with theoretical predictions.Results.From seismology the primary of KIC 9163796 is a star of 1.39 ± 0.06M⊙, while the spectroscopic mass ratio between both components can be determined with much higher precision by spectral disentangling to be 1.015 ± 0.005. With such mass and a difference in effective temperature of 600 K from spectroscopy, the secondary and primary are, respectively, in the early and advanced stage of the first dredge-up event on the red-giant branch. The period of the primary’s surface rotation resembles the orbital period within ten days. The radial rotational gradient between the surface and core in KIC 9163796 is found to be 6.9−1.0+2.0. This is a low value but not exceptional if compared to the sample of typical single field stars. The seismic average of the envelope’s rotation agrees with the surface rotation rate. The lithium’abundance is in agreement with quasi rigidly rotating models.Conclusions.The agreement between the surface rotation with the seismic result indicates that the full convective envelope is rotating quasi-rigidly. The models of the lithium abundance are compatible with a rigid rotation in the radiative zone during the main sequence. Because of the many constraints offered by oscillating stars in binary systems, such objects are important test beds of stellar evolution.
Supervised detection of exoplanets in high-contrast imaging sequences
Authors: Gomez Gonzalez C. A. , Absil O. , Van Droogenbroeck M. 
Published: December 2017

Context.Post-processing algorithms play a key role in pushing the detection limits of high-contrast imaging (HCI) instruments. State-of-the-art image processing approaches for HCI enable the production of science-ready images relying on unsupervised learning techniques, such as low-rank approximations, for generating a model point spread function (PSF) and subtracting the residual starlight and speckle noise.Aims.In order to maximize the detection rate of HCI instruments and survey campaigns, advanced algorithms with higher sensitivities to faint companions are needed, especially for the speckle-dominated innermost region of the images.Methods.We propose a reformulation of the exoplanet detection task (for ADI sequences) that builds on well-established machine learning techniques to take HCI post-processing from an unsupervised to a supervised learning context. In this new framework, we present algorithmic solutions using two different discriminative models: SODIRF (random forests) and SODINN (neural networks). We test these algorithms on real ADI datasets from VLT/NACO and VLT/SPHERE HCI instruments. We then assess their performances by injecting fake companions and using receiver operating characteristic analysis. This is done in comparison with state-of-the-art ADI algorithms, such as ADI principal component analysis (ADI-PCA).Results.This study shows the improved sensitivity versus specificity trade-off of the proposed supervised detection approach. At the diffraction limit, SODINN improves the true positive rate by a factor ranging from ~2 to ~10 (depending on the dataset and angular separation) with respect to ADI-PCA when working at the same false-positive level.Conclusions.The proposed supervised detection framework outperforms state-of-the-art techniques in the task of discriminating planet signal from speckles. In addition, it offers the possibility of re-processing existing HCI databases to maximize their scientific return and potentially improve the demographics of directly imaged exoplanets.
Reversal of Oral Anticoagulants for Intracerebral Hemorrhage Patients: Best Strategies
Authors: Fuh Lanting , Sin Jonathan , Goldstein Joshua , Hayes Bryan 
Published: December 2017

AbstractIn patients with acute intracerebral hemorrhage (ICH), one of the major concerns is ongoing bleeding or ICH expansion. Anticoagulated patients are at higher risk of ongoing expansion and worse outcome. It may be that rapid anticoagulation reversal can reduce the risk of expansion and improve clinical outcome. For those taking coumarins, the best available evidence suggests that intravenous vitamin K combined with four-factor prothrombin complex concentrate (4F-PCC) is the most rapid and effective regimen to restore hemostasis. For those on dabigatran, the highest quality data available for reversal are for idarucizumab, although it is not yet clear whether patients derive clinical benefit from this reversal. In the absence or failure of idarucizumab, activated prothrombin complex concentrate (aPCC) is recommended. For those on factor Xa inhibitors, the ideal reversal agent is not clear. Many providers use 4F-PCC or aPCC, but more specific agents are in clinical trials and may soon be available. In addition, the half-lives of the non–vitamin K antagonists are relatively short compared with warfarin, and so some patients may not have a clinically relevant coagulopathy at the time of presentation. Overall, the optimal reversal agent, when one is required, is a function of which anticoagulant the patient is taking.
Quintessence of Foods that Heal after Surgery
Authors: Shukla Chetna 
Published: December 2017

AbstractIn my work with individualised foods, I recognised that some patients improved more rapidly than others, when they consumed foods that were nourishing and that addressed their nutritional deficiencies and dispositional deficiencies. This article is about foods that aid in healing after surgery. Surgeons say: ‘your body needs good food to rebuild and recover. I have done my part. Now your immune system and good food will take care!’ Examining the phenomenon around surgical intervention I saw a dynamic link between foods, popularly prescribed by nutritionists for healing after surgery and those prescribed on the Law of Similar.
I Feel ‘Being Outcast’: A Case of Hura brasiliensis
Authors: Goel Aman 
Published: December 2017

AbstractThis is a case based on my personal experience at Cure Foundation, Meerut, with the remedy Hura brasiliensis. In accordance with the sensation way of practicing homeopathy, this case study reveals the essence of Hura brasiliensis, as a remedy while understanding the core value of Leprosy miasm in the autoimmune disease of psoriasis. Hura brasiliensis, being the principle remedy of Leprosy miasm, incorporates the sensation of ‘being outcast’ from the world and ‘being unfortunate’.
A Case Report on Diabetic Foot Gangrene
Authors: Murthy Deepthi , Murthy Krishna 
Published: December 2017

AbstractWe report a case of diabetic foot gangrene that was treated with homeopathic therapy which avoided a need for amputation of the limb. From this case report, we would like to suggest that there are better options like homeopathic therapy for a patient with diabetic foot gangrene rather than considering them for the amputation.
Linking Provings and Sources
Authors: Wichmann Jörg 
Published: December 2017

AbstractSince there is great interest in new homeopathic remedies, new provings and new systems for grouping and understanding remedies, Homoeopathic Links wants to inform all homeopaths via this rubric about new developments. Proving conductors are invited to send their provings to us. We will mention the proving in the column and you can decide whether you also want the proving on the Web site (www.provings.info) and/or make it available by email. Besides sending the proving, you can also opt for an article about the proving that is restricted to 900 words (one page). In this article, you can include information on the substance, where to get the remedy, themes coming out of the proving and a very short description of the methodology.The Web site where you can find all provings is www.provings.info.Presented here is a review of Paul Anderson Theriault's landmark book ‘The Table of Animals’.
About a Woman Searching for Her Body
Authors: Van Hootegem Henk 
Published: December 2017

AbstractThis is a report of a 17-year-long therapy of a woman with severely disturbed body image and fragmentation of self-consciousness. I want to focus not only on the healing effect of the homeopathic medicine but also on the importance of a stable, containing therapeutic relationship where there is space and time for working with dreams, integrating ‘negative’ emotions and thoughts and becoming conscious of transference with the therapist.
Constitutional Treatment versus Clinical Homeopathy
Authors: Abermann Christoph 
Published: December 2017

AbstractConstitutional treatment by the Kent method is quite often not successful where severe diseases are involved. In such cases, it is better, when looking for a homoeopathic remedy, to go by the pathology of the disease and its accompanying symptoms. A detailed list of the other situations is provided —apart from severe pathologies—where what is called clinical prescription is beneficial. As a homoeopath, one has to have two tool kits: one for constitutional prescription and one for clinical prescription. The numerous differences between the two methods with regards to choice of remedy and potency, the repetition of the remedy and case management are illustrated in a table.
Nicht steroidale Antirheumatika und gastrointestinales Risiko
Authors: Bolten Wolfgang 
Published: December 2017

ZusammenfassungBei somatischen muskuloskelettalen Schmerzerkrankungen werden nicht steroidale Antirheumatika (NSAR) mit Erfolg schmerz- und entzündungslindernd eingesetzt. Dazu hemmen sie die parakrine Synthese von Prostaglandinen (PG), die sowohl schmerzvermittelnd wirken, an anderer Stelle aber „house keeping“ Effekte haben. Dem Organismus stehen für die PG Synthese die Isoenzyme COX-1 und die induzierbare COX-2 zur Verfügung. Durch die Hemmung der COX-1 und konsekutiver Senkung der PG- Spiegel entstehen gastrointestinale Nebenwirkungen der GI-Mukosa. Im Gegensatz zu den traditionellen NSAR hemmen Coxibe selektiv die COX-2 und verursachen deshalb weniger GI-Probleme. Die Komedikation mit Protonenpumpenhemmern oder mit einem synthetischen PG-Analogon senkt die Ulkusrate ebenfalls. Auch andere nicht PG-abhängige Mechanismen schützen die Mukosa. Sie können ebenfalls durch NSAR gestört werden.
Traumata an der Wirbelsäule bei Patienten des rheumatischen Formenkreises
Authors: Delank Karl-Stefan , Planert Michael 
Published: December 2017

ZusammenfassungDie Wirbelsäule des Patienten mit einer rheumatischen Grunderkrankung ist bei einer traumatischen Krafteinwirkung in vielerlei Hinsicht besonders gefährdet. Das mehr oder weniger ankylosierte Achsenskelett des Patienten mit einem Morbus Bechterew kann auch bei geringen Traumata infolge der langen Hebelarme leicht frakturieren. Infolge der verminderten Beweglichkeit, der gesenkten Blickachse und der Beteiligung peripherer Gelenke ist das Sturzrisiko dieser Patienten generell erhöht. Bei diesen Patienten ist eine biomechanisch angepasste, langstreckige mehrsegmentale Versorgung notwendig um eine ausreichende Stabilität zu erzielen. Moderne Implantate ermöglichen z. B. durch Zementaugmentation oder ein spezifisches Implantatdesign eine angemessene Verankerung. Im Frakturfall kann ggf. auch die Aufrichtung einer vorbestehenden Kyphose erfolgen. Hier ist allerdings das nicht unerhebliche neurologische Komplikationsrisiko zu beachten. Patienten mit einer chronischen Polyarthritis sind im Wesentlichen im Fall eines Traumas durch eine mehr oder weniger ausgeprägte Instabilität im Bereich der oberen Halswirbelsäule gefährdet. Aufgrund der überwiegend ligamentären Führung im Bereich des kraniozervikalen Überganges, kann es als Folge der entzündlich-destruierenden Krankheitsaktivität zu einer Instabilität insbesondere im Bewegungssegment C1/2 kommen. Diese Veränderungen gehen oftmals mit unspezifischen, eher geringen Beschwerden einher. Eine akute traumatische Belastung der oberen Halswirbelsäule kann aber zur Manifestation einer relevanten Dislokation führen. Eine dadurch ausgelöste Kompression nervaler Strukturen kann akute vital bedrohliche Zustände hervorrufen. Die frühzeitige chirurgische Stabilisation ist notwendig um das diesbezügliche Risiko zu reduzieren. Die Minderung der Knochendichte ist fast allen Patienten mit einer Erkrankung des rheumatischen Formenkreises gemeinsam. Ursachen sind neben der Grunderkrankung v. a. die medikamentöse Therapie bspw. mit Steroiden. Hinzu kommt eine durch Immobilität hervorgerufene Osteoporose. Alle mit der Osteoporose verbundenen besonderen Aspekte der traumatisierten Wirbelsäule sind daher grundsätzlich auch bei Patienten mit einer Erkrankung des rheumatischen Formenkreises zu berücksichtigen.
Blick über den Zaun
Authors: Herzog Philipp 
Published: December 2017

ZusammenfassungBei dem Text handelt es sich um die Ausarbeitung eines Vortrags, der auf dem Satellitensymposium der Deutschen Balint Gesellschaft (DBG) und der Deutschen Ärztlichen Gesellschaft für Verhaltenstherapie (DÄVT) auf dem Deutschen Kongress für Psychosomatische Medizin Berlin im März 2017 gehalten wurde. Die Balint-Gruppenleiterausbildung in der American Balint Society (ABS) in ihren didaktischen Implikationen und ihrem theoretischen Hintergrund wird den entsprechenden Konzepten in der Deutsche Balint Gesellschaft gegenübergestellt. Trotz unterschiedlicher didaktischer Vorgehensweisen orientieren sich beide an den Richtlinien der International Balint Federation (IBF) für die Balint-Gruppenleiterausbildung. Im Hinblick auf die geplante Kooperation zwischen DBG und DÄVT wird die Interaktionelle Fallarbeit (IFA) als Konzept mit lerntheoretischem Hintergrund diskutiert.
Ernährung bei metabolischem Syndrom – Stoffwechseloptimierung statt nur Gewichtsreduktion
Authors: Walle Hardy 
Published: December 2017

ZUSAMMENFASSUNGEntgegen früherer Annahmen sind metabolisches Syndrom und Zivilisationskrankheiten nicht auf Adipositas zurückzuführen, sondern auf die Nichtalkoholische Fettleber (NAFLD), die auch bei normalem Körpergewicht auftreten kann. Bereits eine Gewichtsreduktion von 4–5 kg innerhalb von 14 Tagen verbessert die Stoffwechsellage, wobei primär ektopes Fett in der Leber und anderen Organen reduziert werden muss. Leberfasten nach Dr. Worm ist eine effektive Therapie zur Leberentfettung, an die sich eine Lebensstiländerung mit regelmäßiger Bewegung und Ernährungsumstellung anschließen sollte.