bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional outcome of debridement, antibiotics and implant retention in periprosthetic joint infection involving the hip
Authors: Grammatopoulos G. , Bolduc M-E. , Atkins B. L. , Kendrick B. J. L. , McLardy-Smith P. , Murray D. W. , Gundle R. , Taylor A. H. 
Published: April 2017

Aims Advocates of debridement, antibiotics and implant retention (DAIR) in hip periprosthetic joint infection (PJI) argue that a procedure not disturbing a sound prosthesis-bone interface is likely to lead to better survival and functional outcome compared with revision. This case-control study aims were to compare outcome of DAIRs for infected primary total hip arthroplasty (THA) with outcomes following primary THA and two-stage revision of infected primary THAs. Patients and Methods We retrospectively reviewed all DAIRs, performed for confirmed infected primary hip arthropasty (n = 82) at out institution, between 1997 and 2013. Data recorded included full patient information and type of surgery. Outcome measures included complications, mortality, implant survivorship and functional outcome. Outcome was compared with two control groups matched for gender and age; a cohort of primary THAs (n = 120) and a cohort of two-stage revisions for infection (n = 66). Results Mean age at DAIR was 69 years (33 to 87) and mean follow-up was eight years (2 to 17; standard deviation (sd) 5). A total of 52 (63%) of DAIRs were for early PJI (less than six weeks). Greater success in the eradication of infection with DAIR was identified with early PJI, comprising an interval less than a week between onset of symptoms and exchange of modular components with the DAIR procedure. Eradication of infection, complications and re-operation rates were similar in the DAIR and two-stage revision groups. For hips with successful eradication of infection with DAIR, the five-year survival (98%; 95% confidence interval (CI) 94 to 100) was similar to the primary THA group (98%; 95% CI 95 to 100) (n = 43; p = 0.3). The DAIR group had inferior mean Oxford Hip Scores (OHS) (38; 12 to 48) compared with the primary THA group (42; 15 to 48) (p = 0.02) but a significantly better mean OHS compared with the two-stage revision group (31; 0 to 48) (p = 0.008). Patients who required only one DAIR for eradication of infection had a similar mean OHS (41; 20 to 48) to the primary THA group (p = 0.2). Conclusion The DAIR procedure is associated with a similar complication rate and ability to eradicate infection as two-stage revision. This study emphasises the need for exchange of modular components for improved chances of eradication of infection. This is the first study showing that DAIR is better than a two-stage revision regarding functional outcome. Cite this article: Bone Joint J 2017;99-B:614–22.
Contemporary failure aetiologies of the primary, posterior-stabilised total knee arthroplasty
Authors: Abdel M. P. , Ledford C. K. , Kobic A. , Taunton M. J. , Hanssen A. D. 
Published: April 2017

AimsThe number of revision total knee arthroplasties (TKA) that are performed is expected to increase. However, previous reports of the causes of failure after TKA are limited in that they report the causes at specific institutions, which are often dependent on referral patterns. Our aim was to report the most common indications for re-operations and revisions in a large series of posterior-stabilised TKAs undertaken at a single institution, excluding referrals from elsewhere, which may bias the causes of failure.Patients and MethodsA total of 5098 TKAs which were undertaken between 2000 and 2012 were included in the study. Re-operations, revisions with modular component exchange, and revisions with non-modular component replacement or removal were identified from the medical records. The mean follow-up was five years (two to 12).ResultsThe Kaplan-Meier ten-year survival without a re-operation, modular component revision and non-modular component revision was 95.7%, 99.3% and 95.3%, respectively. The most common indications for a re-operation were: post-operative stiffness (58%), delayed wound healing (21%), and patellar clunk (11%). The indications for isolated modular component revision were acute periprosthetic joint infection (PJI) (64%) and instability (36%). The most common indications for non-modular component revision were chronic PJI (52%), aseptic loosening (17%), periprosthetic fracture (10%), and instability (10%).ConclusionPost-operative stiffness remains the most common indication for re-operation after TKA. Infection is the most common indication for modular and non-modular component revision. Aseptic loosening was not an uncommon cause of failure, however, it was much less common than in national registry and non-registry data. Focusing on posterior-stabilised TKAs initially performed at our institution allowed for an accurate assessment of the causes of failure in a contemporary specialty practice. Cite this article: Bone Joint J 2017;99-B:647–52.
Induced membrane technique for treating tibial defects gives mixed results
Authors: Morris R. , Hossain M. , Evans A. , Pallister I. 
Published: April 2017

Aims This study describes the use of the Masquelet technique to treat segmental tibial bone loss in 12 patients. Patients and Methods This retrospective case series reviewed 12 patients treated between 2010 and 2015 to determine their clinical outcome. Patients were mostly male with a mean age of 36 years (16 to 62). The outcomes recorded included union, infection and amputation. The mean follow-up was 675 days (403 to 952). Results The mean tibial defect measured 5.8 cm (2 to 15) in length. Of the 12 patients, 11 had an open fracture. Eight underwent fixation with an intramedullary nail, three with plates and one with a Taylor Spatial Frame. The mean interval between stages was 57 days (35 to 89). Bony union was achieved in only five patients. Five patients experienced infective complications during treatment, with two requiring amputation because of severe infection. Conclusion The Masquelet technique was relatively ineffective in achieving union in this series, and was associated with a high rate of infection. Cite this article: Bone Joint J 2017;99-B:680–5.
The protective role of nitric oxide-dependent innate immunosuppression in the early stage of cartilage damage in rats
Authors: Hsu C-C. , Lin C-L. , Jou I-M. , Wang P-H. , Lee J-S. 
Published: April 2017

ObjectivesOsteoarthritis (OA) is the most common form of arthritis, affecting approximately 15% of the human population. Recently, increased concentration of nitric oxide in serum and synovial fluid in patients with OA has been observed. However, the exact role of nitric oxide in the initiation of OA has not been elucidated. The aim of the present study was to investigate the role of nitric oxide in innate immune regulation during OA initiation in rats.MethodsRat OA was induced by performing meniscectomy surgery while cartilage samples were collected 0, 7, and 14 days after surgery. Cartilage cytokine levels were determined by using enzyme-linked immunosorbent assay, while other proteins were assessed by using Western blotResultsIn the time course of the study, nitric oxide was increased seven and 14 days after OA induction. Pro-inflammatory cytokines including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were decreased. L-NG-Nitroarginine methyl ester (L-NAME, a non-specific nitric oxide synthase inhibitor) significantly decreased cartilage nitric oxide and blocked immune suppression. Further, L-NAME decreased Matrix metalloproteinase (MMPs) and increased tissue inhibitor of metalloproteinase (TIMP) expression in meniscectomised rats.ConclusionNitric oxide-dependent innate immune suppression protects cartilage from damage in the early stages of OA initiation in rats. Cite this article: C-C. Hsu, C-L. Lin, I-M. Jou, P-H. Wang, J-S. Lee. The protective role of nitric oxide-dependent innate immunosuppression in the early stage of cartilage damage in rats: Role of nitric oxide in ca rtilage da mage. Bone Joint Res 2017;6:253–258. DOI: 10.1302/2046-3758.64.BJJ-2016-0161.R1.
Life-Cycle Assessment for Wood-Fired Boilers Used in the Wood Products Industry*
Authors: Puettmann Maureen E. , Milota Michael 
Published: April 2017

Abstract
Many wood production facilities use wood-based fuels for steam generation for drying wood or pressing boards or panels. This process contributes to the life-cycle impacts of the products produced downstream. Past life-cycle assessment studies of wood products have relied on wood boiler data sets that represent both the paper and the wood products industries as well as on secondary data from the US Environmental Protection Agency primarily based on the potential to emit or collect from an uncontrolled source. Primary data were collected by survey for the material and energy inputs and outputs of wood-fired boilers at lumber and plywood wood production facilities in the Pacific Northwest and Southeast regions of the United States. The results were averaged to create a life-cycle inventory model to represent wood-fired boilers at wood production facilities. Results indicated that regional differences, as well as type of wood waste burned, did not warrant separate boiler data sets for each industry and region. The model is useful for including the effects of steam production in the life-cycle assessment of wood products. The primary data used in the model should better represent wood-fired boilers used in US wood production facilities than existing data sets do.
Cradle-to-Gate Life-Cycle Impact Analysis of Glued-Laminated (Glulam) Timber: Environmental Impacts from Glulam Produced in the US Pacific Northwest and Southeast*
Authors: Bowers Tait , Puettmann Maureen E. , Ganguly Indroneil , Eastin Ivan 
Published: April 2017

Abstract
This study was an update on the 2000 life-cycle inventory data on material and energy inputs associated with the production of 1 m3 of glued-laminated (glulam) timbers produced in the Pacific Northwest (PNW) and the Southeast (SE) regions of the United States. This article looks at the cradle to gate for the entire glulam production processes, which include forest harvest, lamstock production, and glulam beam production. Data collected from glulam beam manufacturers in 2013 allowed for the development of a life-cycle assessment utilizing the product category rules for North American Structural and Architectural Wood Products so that the results from these analyses can be used for the development of environmental product declarations of glulam beams produced in the United States. Comparing the results of this study with the life-cycle assessment based on the 2000 survey data shows 30 percent reductions in global warming potential of glulam beams produced in both the PNW and the SE and reductions in the use of energy derived from fossil fuels by 40 percent in the PNW and SE. The overall net carbon sequestered in 1 m3 of PNW glulam is equivalent to 938 kg of CO2 and 1,038 kg of CO2 in the SE. Utilizing techniques that reduced the use of electricity and minimizing the transportation distances of the raw materials and resins to the mill could help to further reduce the carbon footprint of the glulam beam manufacturing process.
Role of Online Survey Tools in Creating Temporally Accurate Environmental Product Declarations within the Context of the US Wood Products Industry*
Authors: Ganguly Indroneil , Bowers Tait , Pierobon Francesca , Eastin Ivan 
Published: April 2017

Abstract
An environmental product declaration (EPD) presents quantified environmental information on a product or process in a simplified form. EPDs are based on the life-cycle assessment (LCA) of products conducted in accordance with standards of the International Organization for Standardization. An LCA analysis ensures that the environmental impacts associated with all processes undertaken to produce the product, ranging from extraction (cradle) to its final product stage (gate) or postuse disposal (grave), are included. To be able to present temporally accurate EPDs, the corresponding LCA data need to be updated every 5 to 10 years, depending on the nature of the industry. In this article, we present the pros and cons associated with using Web-based data collection tools to conduct and maintain temporally accurate LCA data. We also present the lessons learned in using Web-based survey tools, with reference to the wood-based industry, and propose a methodology to maintain temporally accurate LCA data with minimal intervention, facilitating periodic update of the EPDs.
Cadmium(II) Complexes Adsorbed on Clay Edge Surfaces: Insight from First Principles Molecular Dynamics Simulation
Authors: Zhang Chi , Liu Xiandong , Lu Xiancai , Meijer Evert Jan , Wang Kai , He Mengjia , Wang Rucheng 
Published: April 2017

AbstractAiming to identify the complexing mechanisms of heavy metal cations on edge surfaces of 2:1-type clay minerals, systemic first-principles molecular dynamics (FPMD) simulations were conducted and the microscopic structures and complex free energies were obtained. Taking Cd(II) as a model cation, the structures on both (010) and (110) edges of the complexes were derived for the three possible binding sites (≡SiO, ≡Al(OH)2/≡AlOH≡AlSiO, and vacant sites). The stable complexes adsorbed on the three binding sites on both terminations had similar structures. The free energies of the complexes on (010) edges were calculated by using the constrained FPMD method. The free energies of complexes on the ≡SiO and ≡Al(OH)2 sites were similar and they were both significantly lower than the free energy of the complex on the octahedral vacant site. In association with the concept of high energy site (HES) and low energy site (LES) in the 2 Site Protolysis Non Electrostatic Surface Complexation and Cation Exchange (2SPNE SC/CE) sorption model, the vacant site was assigned to HES and the other two sites to LES, respectively.
Intercalation of Ethylene Glycol in Smectites: Several Molecular Simulation Models Verified by X-Ray Diffraction Data
Authors: Szczerba Marek , Kalinichev Andrey G. 
Published: April 2017

AbstractOrgano-clays represent a special challenge for molecular simulations because they require accurate representation of the clay and the organic/aqueous sections of the model system and accurate representation of the interactions between them. Due to the broad range of force-field models available, an important question to ask is which sets of parameters will best suit the molecular modeling of the organo-intercalated smectites? To answer this question, the structure of the ethylene glycol (EG)-smectite complex is used here as a testing model because the intercalation of EG in smectites provides a stable interlayer complex with relatively constant basal spacing.Three smectite samples with substantially different layer charge and charge localization were selected for X-ray diffraction (XRD) measurements. Their molecular models were built and molecular-dynamics simulations performed using various combinations of the organic force fields (CGenFF, GAFF, CVFF, and OPLS-aa) with ClayFF and INTERFACE force fields used to describe smectites. The simulations covered a range of different EG and water contents. For every structure, the density distribution of interlayer species along the direction perpendicular to the layer plane was calculated and then used to optimize the XRD patterns for these simulated models.A comparison of these results with experimental XRD patterns shows very large discrepancies in the structures and basal spacings obtained for different layer charges as well as for different force fields and their combinations. The most significant factor affecting the accuracy of the calculated XRD patterns was the selection of the clay-mineral force-field parameters. The second important conclusion is that a slight modification of the basal oxygen parameters for non-electrostatic interactions (increase of their effective atomic diameters) may be a simple and straightforward way to improve significantly the agreement between the modeled XRD patterns with experiments, especially for high-charge smectites. Generally, among organic force fields, the least accurate results were obtained with CGenFF. For unmodified ClayFF, its combination with GAFF gave the best results, while the two other sets (OPLS-aa and CVFF) gave the best results in combination with ClayFFmod. The INTERFACE and INTERFACEmod produced much better results for low-charge montmorillonite than for high-charge smectites.
The Arizona Cognitive Test Battery for Down Syndrome: Test-Retest Reliability and Practice Effects
Authors: Edgin Jamie O. , Anand Payal , Rosser Tracie , Pierpont Elizabeth I. , Figueroa Carlos , Hamilton Debra , Huddleston Lillie , Mason Gina , Spanò Goffredina , Toole Lisa , Nguyen-Driver Mina , Capone George , Abbeduto Leonard , Maslen Cheryl , Reeves Roger H. , Sherman Stephanie 
Published: April 2017

Abstract
A multisite study investigated the test-retest reliability and practice effects of a battery of assessments to measure neurocognitive function in individuals with Down syndrome (DS). The study aimed to establish the appropriateness of these measures as potential endpoints for clinical trials. Neurocognitive tasks and parent report measures comprising the Arizona Cognitive Test Battery (ACTB) were administered to 54 young participants with DS (7–20 years of age) with mild to moderate levels of intellectual disability in an initial baseline evaluation and a follow-up assessment 3 months later. Although revisions to ACTB measures are indicated, results demonstrate adequate levels of reliability and resistance to practice effects for some measures. The ACTB offers viable options for repeated testing of memory, motor planning, behavioral regulation, and attention. Alternative measures of executive functioning are required.
Cross-sectional Analysis of AGE-CML, sRAGE, and esRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort
Authors: Loomis Stephanie J , Chen Yuan , Sacks David B , Christenson Eric S , Christenson Robert H , Rebholz Casey M , Selvin Elizabeth 
Published: April 2017

Abstract

BACKGROUND
Advanced glycation end products (AGEs) and their receptors are regarded as central to the development of diabetic complications, but associations with diabetes and cardiometabolic outcomes in previous studies are mixed.

METHODS
Using ELISA assays, we measured N(6)-carboxymethyllysine (AGE-CML), soluble receptor for AGEs (sRAGE), and endogenous secreted receptor for AGEs (esRAGE) in 1874 participants from the Atherosclerosis Risk in Communities study. We conducted a cross-sectional analysis to evaluate associations of these biomarkers with demographics, diabetes, hyperglycemia, cardiometabolic measures, and genetic variants in the gene encoding RAGE, AGER (advanced glycosylation end-product specific receptor).

RESULTS
After adjustment for demographics and body mass index (BMI), there were no significant differences in AGE-CML, sRAGE, or esRAGE by diabetes or hemoglobin A1c. Black race and AGER genetic variants were strongly associated with lower sRAGE and esRAGE even after adjustment [percent difference (95% CI) in black vs whites in sRAGE: −29.17 (−34.86 to −23.48), esRAGE: −26.97 (−33.11 to −20.84); with rs2070600 in sRAGE: −30.13 (−40.98 to −19.29), and esRAGE: −30.32 (−42.42 to −18.21); with rs2071288 in sRAGE: −20.03 (−34.87 to −5.18), and esRAGE: −37.70 (−55.75 to −19.65)]. Estimated glomerular filtration rate and albuminuria significantly correlated with sRAGE and esRAGE. BMI and C-reactive protein significantly negatively correlated with AGE-CML, sRAGE, and esRAGE. AGE-CML was modestly correlated with fructosamine and glycated albumin.

CONCLUSIONS
AGE-CML, sRAGE, and esRAGE were more related to genetic, kidney, and inflammatory measures than to diabetes in this community-based population. Our results suggest that, when measured by ELISA, these biomarkers lack specificity and are of limited value in evaluating the role of these compounds in diabetes.
Book Review
Authors: Yoneno-Reyes Michiyo 
Published: April 2017

Abstract
DUBIOUS GASTRONOMY: THE CULTURAL POLITICS OF EATING ASIAN IN THE USA, ROBERT JI-SONG KU (2014) Honolulu: University of Hawai’i Press, x and 290 pp., ISBN: 9780824839970, p/bk, $28.00
Education Support by Research in Local Transportation History
Authors: Štefanovič Juraj , Schindler Frank 
Published: April 2017

Abstract
Aim of the article is to present our research dealing with virtual reality modeling and education activities. It involves a chain of development steps: taking pictures of objects, collecting information, creation of 3D models and panoramas, setting up the interactive virtual reality environment along with educational support and testing the user experience with students. Methodology/methods of work: the creation of 3D models and panoramas is done by taking pictures of real objects and using them as textures. The education materials are created as interactive presentations and the usability testing of these presentations should be planned. Scientific goal is to measure the quality of interaction by this education support in order to derive rules testing effectiveness of support, interactive applications and presentations. Findings: 3D models and other educational support materials may be created voluntarily by teachers. The open source library for many different models should be created by whole community provided suitable interfaces of modeling tools will be arranged. Conclusions: Complex educational and interactive materials including virtual reality and panoramas are satisfactory when combined with easy 3D models that are made from taken pictures, which could be made by teachers themselves and/or open communities by existing cameras.
Role of Acetone in the Formation of Highly Dispersed Cationic Polystyrene Nanoparticles
Authors: Ernawati Lusi , Balgis Ratna , Ogi Takashi , Okuyama Kikuo , Takada Tomonori 
Published: April 2017

Abstract
A modified emulsion polymerisation synthesis route for preparing highly dispersed cationic polystyrene (PS) nanoparticles is reported. The combined use of 2,2′-azobis[2-(2-imidazolin- 2-yl)propane] di-hydrochloride (VA-044) as the initiator and acetone/water as the solvent medium afforded successful synthesis of cationic PS particles as small as 31 nm in diameter. A formation mechanism for the preparation of PS nanoparticles was proposed, whereby the occurrence of rapid acetone diffusion caused spontaneous rupture of emulsion droplets into smaller droplets. Additionally, acetone helped to reduce the surface tension and increase the solubility of styrene, thus inhibiting aggregation and coagulation among the particles. In contrast, VA-044 initiator could effectively regulate the stability of the PS nanoparticles including both the surface charge and size. Other reaction parameters i.e. VA-044 concentration and reaction time were examined to establish the optimum polymerisation conditions.
Energetic Efficiency of Mixing and Mass Transfer in Single Phase and Two-Phase Systems
Authors: Bałdyga Jerzy , Jasińska Magdalena 
Published: April 2017

Abstract
In this work a concept of energetic efficiency of mixing is presented and discussed; a classical definition of mixing efficiency is modified to include effects of the Schmidt number and the Reynolds number. Generalization to turbulent flows is presented as well. It is shown how the energetic efficiency of mixing as well as efficiencies of drop breakage and mass transfer in twophase liquid-liquid systems can be identified using mathematical models and test chemical reactions. New expressions for analyzing efficiency problem are applied to identify the energetic efficiency of mixing in a stirred tank, a rotor stator mixer and a microreactor. Published experimental data and new results obtained using new systems of test reactions are applied. It has been shown that the efficiency of mixing is small in popular types of reactors and mixers and thus there is some space for improvement.