bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and characterization of high quantum yield and oscillator strength 6‐chloro‐2‐(4‐cynophenyl)‐4‐phenyl quinoline (cl‐CN‐DPQ) organic phosphor for solid‐state lighting
Authors: Ghate Minakshi , Dahule H. K. , Thejo Kalyani N. , Dhoble S. J. 
Published: October 2017

AbstractA novel blue luminescent 6‐chloro‐2‐(4‐cynophenyl) substituted diphenyl quinoline (Cl‐CN DPQ) organic phosphor has been synthesized by the acid‐catalyzed Friedlander reaction and then characterized to confirm structural, optical and thermal properties. Structural properties of Cl‐CN‐DPQ were analyzed by Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) spectroscopy, X‐ray diffraction technique (XRD) and scanning electron microscopy (SEM) and energy dispersive analysis of X‐ray (EDAX) spectroscopy. FTIR spectra confirmed the presence of different functional groups and bond stretching. 1H–NMR and 13C–NMR confirmed the formation of an organic Cl‐CN‐DPQ compound. X‐ray diffraction study provided its crystalline nature. The surface morphology of Cl‐CN‐DPQ was analyzed by SEM, while EDAX spectroscopy revealed the elemental analysis. Differential thermal analysis (TGA/DTA) disclosed its thermal stability up to 250°C. The optical properties of Cl‐CN‐DPQ were investigated by UV–vis absorption and photoluminescence (PL) measurements. Cl‐CN‐DPQ exhibits intense blue emission at 434 nm in a solid‐state crystalline powder with CIE co‐ordinates (0.157, 0.027), when excited at 373 nm. Cl‐CN‐DPQ shows remarkable Stokes shift in the range 14800–5100 cm−1, which is the characteristic feature of intense light emission. A narrow full width at half‐maximum (FWHM) value of PL spectra in the range 42–48 nm was observed. Oscillator strength, energy band gap, quantum yield, and fluorescence energy yield were also examined using UV–vis absorption and photoluminescence spectra. These results prove its applications towards developing organic luminescence devices and displays, organic phosphor‐based solar cells and displays, organic lasers, chemical sensors and many more.
Highly luminescent nitrogen‐doped carbon dots for simultaneous determination of chlortetracycline and sulfasalazine
Authors: Zhang Zhengwei , Chen Jianqiu , Duan Yu , Liu Weixia , Li Dan , Yan Zhengyu , Yang Ke 
Published: October 2017

AbstractHere, we have presented a green and facile strategy to fabricate nitrogen‐doped carbon dots (N‐CDs) and their applications for determination of chlortetracycline (CTC) and sulfasalazine (SSZ). The fluorescent N‐CDs, prepared by one‐step hydrothermal reaction of citric acid and l‐arginine, manifested numerous excellent features containing strong blue fluorescence, good water‐solubility, narrow size distribution, and a high fluorescence quantum yield (QY) of 38.8%. Based on the fluorescence quenching effects, the as‐synthesized N‐CDs as a fluorescent nanosensor exhibited superior analytical performances for quantifying CTC and SSZ. The linear range for CTC was calculated to be from 0.85 to 20.38 μg ml−1 with a low detection limit of 0.078 μg ml−1. Meanwhile, the linear range for SSZ was estimated to be from 0.34 to 6.76 μg ml−1 with a low detection limit of 0.032 μg ml−1. Therefore, the N‐CDs hold admirable application potential for constructing a fluorescent sensor for pharmaceutical analysis.
Solvent Effect on the Photoinduced Structural Change of a Phosphorescent Molecular Butterfly
Authors: Ma Ying‐Zhong , Zhou Chenkun , Doughty Benjamin , Easley Davis C. , Deterding Justin , Ma Biwu 
Published: October 2017

AbstractPhotoinduced structural changes (PSC) is one of the fundamental excited‐state dynamic processes, and yet often very challenging to distinguish from competing electronic excited‐state relaxation channels having similar or even comparable timescales. Here, we report a detailed study on the PSC of a pyrazolate bridged platinum(II) binuclear complex, BFPtPZ (C^NPt(μ‐pz′)2PtC^N, C^N=2‐(2,4‐difluorophenyl)pyridine, pz′=pyrazolate), a molecular butterfly, using time‐correlated single photon counting measurements at different wavelengths and sample temperatures. Analysis of the results obtained using dichloromethane (DCM) and ethylene carbonate (EC) as solvents enabled us to reveal an unexpected, strong solvent effect on the PSC processes. We show that a rapid PSC process with a characteristic timescale of 323 ps is observed in DCM, which leads to an excitation equilibrium between the ligand center/metal‐to‐ligand charge transfer (3LC/MLCT) and metal‐metal‐to‐ligand charge transfer (3MMLCT) triplet states. The subsequent relaxation from these electronic states to the ground state takes place in several nanoseconds. In contrast, the corresponding PSC process in EC appears slow at all temperatures studied in our experiments and showed no sign of such excitation equilibrium. The observed solvent effect is found to arise from distinct solvent properties including their viscosities and polarities as well as the peculiar electronic excited‐states of the butterfly‐like molecules with charge transfer character.
Synthesis and Photophysical Characterization of 2,3‐Dihydroquinolin‐4‐imines: New Fluorophores with Color‐Tailored Emission
Authors: Chou Chih‐Hung , Rajagopal Basker , Liang Chien‐Fu , Chen Kuan‐Lin , Jin Dun‐Yuan , Chen Hsing‐Yin , Tu Hsiu‐Chung , Shen Yu‐Ying , Lin Po‐Chiao 
Published: October 2017

AbstractIn this study, a series of variously substituted 2,3‐dihydroquinolin‐4‐imines (DQIs) were synthesized from N‐substituted propargylanilines by copper(I)‐catalyzed annulation. The approach adopted in this study under mild, effective conditions exhibited broad substrate tolerance, particularly for functional groups substituted on anilines. Most of the DQI derivatives synthesized under optimal conditions were obtained in good isolated yields of 63–88 %. 2,3‐Dihydroquinolinimine thus obtained was easily converted to important structures like 2,3‐dihydroquinolone and tetrahydrobenzodiazepin‐5‐one, confirming the importance of this strategy in constructing various heterocycles. Surprisingly, 2,3‐dihydroquinolinimines thus obtained exhibited bright fluorescence with quantum yields up to 66 %. The density functional theory (DFT) and time‐dependent DFT (TD‐DFT) calculations were performed for understanding the excited‐state nature of DQI system. Accordingly, a tailored DQI derivative bearing methoxy group at C‐6 position and acetoxy group at C‐7 position was designed and synthesized to give emission at 559 nm with redshift compared to the 7‐methoxy substituted DQI. A detailed study of DQI structures with their photophysical properties was performed with five control molecules and consequently demonstrated the uniqueness of the chemical structures of DQIs.
Transuranic Computational Chemistry
Authors: Kaltsoyannis Nikolas 
Published: October 2017

AbstractRecent developments in the chemistry of the transuranic elements are surveyed, with particular emphasis on computational contributions. Examples are drawn from molecular coordination and organometallic chemistry, and from the study of extended solid systems. The role of the metal valence orbitals in covalent bonding is a particular focus, especially the consequences of the stabilization of the 5f orbitals as the actinide series is traversed. The fledgling chemistry of transuranic elements in the +II oxidation state is highlighted. Throughout, the symbiotic interplay of experimental and computational studies is emphasized; the extraordinary challenges of experimental transuranic chemistry afford computational chemistry a particularly valuable role at the frontier of the periodic table.
International Inbound Open Innovation and International Performance
Authors: Romero‐Martínez Ana M. , García‐Muiña Fernando E. , Ghauri Pervez N. 
Published: October 2017

AbstractThis work analyzes the relationship between international inbound open innovation and international performance,including the complementary role played by firms' intellectual capital. Based on a survey of 8,973 Spanish manufacturing firms, the findings confirm that externalization by means of international inbound open innovation, both strategically and financially, favours international performance measured in terms of international patents. Regarding the moderating effect of intellectual capital, the results show that both human and technological capital boost the impact of international inbound open innovation on international performance. Organizational capital also increases the benefits of financial inbound open innovation; however, it impacts negatively in the case of strategic inbound open innovation. The additional benefits of externalization may add extra value to international performance. Copyright © 2017 ASAC. Published by John Wiley & Sons, Ltd.
Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives
Authors: Rybka Sabina , Obniska Jolanta , Żmudzki Paweł , Koczurkiewicz Paulina , Wójcik‐Pszczoła Katarzyna , Pękala Elżbieta , Bryła Adrian , Rapacz Anna 
Published: October 2017

AbstractA new series of 1,3‐substituted pyrrolidine‐2,5‐dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal administration. Quantitative pharmacological research revealed that the most promising compounds were N‐[{4‐(3‐trifluoromethylphenyl)piperazin‐1‐yl}propyl]‐3‐benzhydrylpyrrolidine‐2,5‐dione monohydrochloride (11) with a ED50 value of 75.9 mg kg−1 (MES test) and N‐[{4‐(3,4‐dichlorophenyl)piperazin‐1‐yl}ethyl]‐3‐methylpyrrolidine‐2,5‐dione monohydrochloride (18) with ED50=88.2 mg kg−1 (MES test) and ED50=65.7 kg mg−1 (scPTZ test). These compounds displayed a more beneficial protective index than well‐known antiepileptic drugs. A plausible mechanism of action of compounds 11 and 18 [molecule 11 blocked the sodium channel (site 2) and 18 blocked both the sodium (site 2) and L‐type calcium channels] and their preliminary safety in vitro were evaluated. Besides, the lipophilicity of all synthesized compounds was determined by using UPLC–MS.
Co‐Differentiation of Human Pluripotent Stem Cells‐Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three‐Dimensional Model of Cardiac Microtissue
Authors: Giacomelli Elisa , Bellin Milena , Orlova Valeria V. , Mummery Christine L. 
Published: October 2017

AbstractThe formation of cardiac mesodermal subtypes is highly regulated in time and space during heart development. In vitro models based on human pluripotent stem cells (hPS cells) provide opportunities to study mechanisms underlying fate choices governing lineage specification from common cardiovascular progenitors in human embryos. The generation of cardiac endothelial cells in particular allows the creation of complex models of cardiovascular disorders in which either cardiomyocytes or endothelial cells are affected. Here, a protocol for co‐differentiation of cardiomyocytes and endothelial cells from cardiac mesoderm using hPS cells is described. Precise details for the enrichment of each cell population from heterogeneous‐differentiated cultures, a description of how to maintain and dissociate enriched cardiomyocytes, and the expansion and cryopreservation of enriched endothelial cells are all provided. The generation and culture of three‐dimensional cardiac microtissues from these cell populations is described and guidelines for the characterization of microtissues by immunofluorescent staining and re‐plating for downstream applications are provided. © 2017 by John Wiley & Sons, Inc.
An identity attribute–based encryption using elliptic curve digital signature for patient health record maintenance
Authors: Athena J. , Sumathy V. , Kumar K. 
Published: October 2017

SummaryProviding security to the data that stored in personal health record (PHR) is an emerging and critical task in recent years. For this purpose, some of the encryption and key generation techniques are developed in the traditional works. But it has the drawbacks such as lacks in access control policies, reduced security, and ineffective. So this work implemented the efficient techniques, namely, elliptic curve Diffie‐Hellman for the secret key generation and identity attribute–based encryption for improving the security of the cloud data. Initially, the cloud user can request the patient's data to the PHR admin, and then they can generate the secret by using the elliptic curve Diffie‐Hellman algorithm. The key that used for encryption and decryption is generated by using the identity attribute–based encryption technique. Then, the access control is provided to the users based on their roles. The requested data are encrypted by applying the advanced encryption standard technique. After that, the elliptic curve digital signature algorithm is used to generate the digital signature for the encrypted data. Furthermore, it is verified with the user's digital signature; if it matches, the data can be accessed by the user with the help of advanced encryption standard decryption mechanism. Finally, the authenticated user can able to access the patient's data from PHR. In experiments, the performance of the proposed encryption and key generation technique is evaluated and compared with the existing techniques for proving the effectiveness of the implemented system.
Connectivity, persistence, and loss of high abundance areas of a recovering marine fish population in the Northwest Atlantic Ocean
Authors: Boudreau Stephanie A. , Shackell Nancy L. , Carson Stuart , den Heyer Cornelia E. 
Published: October 2017

AbstractIn the early 1990s, the Northwest Atlantic Ocean underwent a fisheries‐driven ecosystem shift. Today, the iconic cod (Gadus morhua) remains at low levels, while Atlantic halibut (Hippoglossus hippoglossus) has been increasing since the mid‐2000s, concomitant with increasing interest from the fishing industry. Currently, our knowledge about halibut ecology is limited, and the lack of recovery in other collapsed groundfish populations has highlighted the danger of overfishing local concentrations. Here, we apply a Bayesian hierarchical spatiotemporal approach to model the spatial structure of juvenile Atlantic halibut over 36 years and three fisheries management regimes using three model parameters to characterize the resulting spatiotemporal abundance structure: persistence (similarity of spatial structure over time), connectivity (coherence of temporal pattern over space), and spatial variance (variation across the seascape). Two areas of high juvenile abundance persisted through three decades whereas two in the northeast are now diminished, despite the increased abundance and landings throughout the management units. The persistent areas overlap with full and seasonal area closures, which may act as refuges from fishing. Connectivity was estimated to be 250 km, an order of magnitude less than the distance assumed by the definition of the Canadian management units (~2,000 km). The underlying question of whether there are distinct populations within the southern stock unit cannot be answered with this model, but the smaller ~250 km scale of coherent temporal patterns suggests more complex population structure than previously thought, which should be taken into consideration by fishery management.
Payments for Ecosystem Services as a Policy Mix: Demonstrating the institutional analysis and development framework on conservation policy instruments
Authors: Barton David N. , Benavides Karla , Chacon‐Cascante Adriana , Le Coq Jean‐Francois , Quiros Miriam Miranda , Porras Ina , Primmer Eeva , Ring Irene 
Published: October 2017

AbstractPolicy mix analysis has been applied in research on energy, climate, urban and transport policy, and more recently biodiversity conservation and ecosystem services. However, policy mix analysis has thus far been employed at a high conceptual level, focusing on describing interactions between instrument types. Policy mix analysis rarely describes instrument ‘structure’ or functional characteristics in a way that would answer the question ‘what constitutes an instrument’? We describe how the rules‐in‐use taxonomy of the Institutional Analysis and Development (IAD) framework, developed for research on common pool resource management, can be used to characterize conservation policy instrument interactions. We demonstrate the approach on the well‐known payments for ecosystem services (PES) program in Costa Rica and cross‐compliance policies, arguing that PES is a policy mix rather than a single economic instrument. Our analysis shows how design features of PES described in the economics literature map to ‘rules‐in‐use’ in the IAD framework. The framework provides a terminology for defining what constitutes institutional context, comparing economic, regulatory and information instruments, and studying their interactions. The rules‐in‐use taxonomy of IAD is a ‘structural’ diagnostic approach, which needs to be combined with other tools that analyse the role and ‘agency’ of actors, as part of integrative environmental governance research. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
The Economic and Legal Sides of Additionality in Payments for Environmental Services
Authors: Karsenty Alain , Aubert Sigrid , Brimont Laura , Dutilly Céline , Desbureaux Sébastien , Ezzine de Blas Driss , Le Velly Gwenole 
Published: October 2017

AbstractThis paper aims to clarify two distinct but complementary questions on economic and legal additionality in the payments for environmental services (PES) debate based on examples from the literature and direct observations made in Madagascar and Mexico. For the economic dimension of additionality, we explain two ‘regimes of justification’, efficiency on the one hand and social equity on the other, and discuss how analysts position themselves with regard to both regimes. For the legal dimension, we review and analyse specific cases in which PES are implemented in addition to existing environmental regulations. We propose a renewed framework of analysis to distinguish ‘compensation’ and ‘reward’ in PES by crossing the opportunity cost dimension and the legal constraint vis‐à‐vis the environment. We show how difficult it is to fully maintain the objective of efficiency when PES are implemented simultaneously across different combinations of opportunity costs and regulation constraints. We propose policy options to address the contradiction between incentive and coercive instruments. These options are land sparing, social targeting and chronological combinations. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Promotion of phenolic compounds production in Salvia miltiorrhiza hairy roots by six strains of rhizosphere bacteria
Authors: You Hong , Yang Suijuan , Zhang Lu , Hu Xiufang , Li Ou 
Published: October 2017

AbstractSalvia miltiorrhiza Bunge is an important herb for the treatment of cerebrovascular and cardiovascular diseases with bioactive compounds (phenolic acids and tanshinones). Abundant studies showed that tanshinones could be stimulated by biotic and abiotic stresses, but limited information is available on biosynthesis of phenolic acids promoted by biotic stresses. The aim of the present work was to isolate and identify rhizosphere bacteria which stimulated phenolic compound in Salvia miltiorrhiza hairy roots and investigated the internal mechanism, providing a potential means to enhance content of pharmaceuticals in S. miltiorrhiza. The results showed that six bacteria, namely, HYR1, HYR26, SCR22, 14DSR23, DS6, and LNHR13, belonging to the genus Pseudomonas and Pantoea, significantly promoted the growth and content of major phenolic acids, RA and SAB. Bacteria LNHR13 was the most effective one, with the contents of RA and SAB reaching ∼2.5‐fold (30.1 mg/g DW) and ∼2.3‐fold (48.3 mg/g DW) as those of the control, respectively. Phytohormones and polysaccharides produced by bacteria showed potential responsibility for the growth and biosynthesis of secondary metabolites of S. miltiorrhiza. Meanwhile, we found that the more abundant the types and contents of phytohormones, the stronger their stimulating effect on the content of salvianolic acids.
Relative reductions in health care utilization among young adults before aging out of extended dependent coverage
Authors: Chen Weiwei 
Published: October 2017

SummaryThe 2010 Affordable Care Act extended dependent coverage for adult children up to age 26 in the USA. Since then, considerable studies have assessed its various impacts among young adults. However, little is known about whether there is any change in health care use when young adults age out of dependent coverage. This study examines health care consumption changes among young adults prior to their aging out process. I used data from a large insurance claim database and studied health care utilization of young adults under parents' coverage during a 2‐year period in a difference‐in‐difference framework. I found that young adults had relative reductions in health services use, except ER visits, compared with individuals who stayed under parents' coverage. This pattern was the same for both male and females. Individuals with regular medical needs had greater relative reductions compared with those without regular medical needs. The relative reductions in health care use during the aging out process may have an important impact on young adults' health, especially for those with regular medical needs. More efforts could be made to help them maintain regular medical utilization during the transition.
Sustained FXN expression in dorsal root ganglia from a nonreplicative genomic HSV‐1 vector
Authors: Ventosa Maria , Wu Zetang , Lim Filip 
Published: October 2017

AbstractBackgroundFriedreich's ataxia (FA) is an autosomal recessive neurodegenerative disease caused by mutations in the frataxin gene (FXN), which lead to reduced levels of the essential mitochondrial protein frataxin. Currently, there is no effective cure.MethodsWith the aim of developing a gene therapy for FA neuropathology, we describe the construction and preliminary characterization of a high‐capacity nonreplicative genomic herpes simplex virus type 1 vector (H24B‐FXNlac vector) carrying a reduced version of the human FXN genomic locus, comprising the 5‐kb promoter and the FXN cDNA with the inclusion of intron 1.ResultsWe show that the transgene cassette contains the elements necessary to preserve physiological neuronal regulation of human FXN expression. Transduction of cultured fetal rat dorsal root ganglia neurons with the H24B‐FXNlac vector results in sustained expression of human FXN transcripts and frataxin protein. Rat footpad inoculation with the H24B‐FXNlac vector results in human FXN transgene delivery to the dorsal root ganglia, with expression persisting for at least 1 month.ConclusionsThe results of the present study support the feasibility of using this vector for sustained neuronal expression of human frataxin for FA gene therapy.