bluuebunny/crossref_metadata_2025_split huggingface dataset:
أثر استخدام برنامج إرشاد جمعي يستند إلى النظرية السلوكية المعرفية في تحسين درجة التكيف الاجتماعي وخفض الكمالية السلبية لدى الطلبة الموهوبين من ذوي الاحتياجات الخاصة في امارة ابو ظبي
Authors: Dr. Manar Mahmoud Ahmed Al-Rayahneh  , Dr. Khaled Al-Abri  
Published: September 2024

ﺃﻥ ﺍﻟﻁﻠﺒﺔ ﺍﻟﻤﻭﻫﻭﺒﻴﻥ ﻭﺍﻟﻤﺘﻔﻭﻗﻴﻥ ﺒﺤﺎﺠﺔ ﺇﻟـﻰ ﺭﻋﺎﻴـﺔ ﺘﺭﺒﻭﻴـﺔ ﻭﺨﺩﻤﺎﺕ ﻤﺘﻤﻴﺯﺓ ﻋﻥ ﺍﻟﺒﺭﺍﻤﺞ ﻭﺍﻟﺨﺩﻤﺎﺕ ﺍﻟﺘﻘﻠﻴﺩﻴﺔ ﺍﻟﻤﺘﻭﺍﻓﺭﺓ ﻓﻲ ﺍﻟﻤﺩﺍﺭﺱ والمراكز ﺍﻟﻌﺎﺩﻴﺔ وترى الباحثة ان الطلبة الموهوبون المعاقين بحاجة الى رعاية، وبحاجة الى توجيه وإرشاد لخفض الكمالية السلبية، وعلى قطاعات التربية الاهتمام بتقديم برامج خاصة بهم لكي تثري الجانب الابداعي تكمن مشكلة الدراسة الحالية في الاجابة على التساؤل الرئيسي الاتي:

ما إثر البرنامج الارشادي في تحسين التكيف الاجتماعي وخفض الكمالية السلبية للطلبة الموهوبين المعاقين؟

تهدف الدراسة الحالية الى تحسين التكيف الاجتماعي وخفض الكمالية السلبية للموهوبين من خلال بناء برنامج يستند الى النظرية السلوكية المعرفية، وكذلك تهدف الى مساعدة اعضاء المجموعة الارشادية في زيادة اثراء قدراتهم وامكاناتهم حتى تنعكس عليهم وعلى المجتمع الذي يعيشون فيه. وشملت عينة الدراسة على (40) طالباً وطالبة من مدرسة مبارك بن محمد في امارة ابو ظبي ,وتم اختيار العينة بالطريقة القصدية واستخدم الباحثان برنامج ارشاد جمعي و مقياس التكيف الاجتماعي وبناء مقياس لخفض الكمالية السلبية . ومن اهم الاستنتاجات :- نجاح البرنامج الإرشادي في التقليل من اثر الكمالية السلبية وأيضا الى تنوع الاستراتيجيات التي استخدمت للتقليل والتخفيف من اثرها السلبي على الموهبين , عدم وجود فروق الى ان الذكور والاناث قد تعرضوا لنفس البرنامج الارشادي ونفس الاستراتيجيات الإرشادية والمدة الزمنية لهذا لم تكن هناك فروق داله إحصائية تعزى للجنس.
Pelatihan untuk Penerapan Teknologi Pengolahan Minuman Gel Lidah Buaya di Ghra Sambiroto, Nanggulan, Kulon Progo, DIY
Authors: Wariyah Chatarina , Slamet Agus , Subronto Yanri Wijayanti 
Published: September 2024

Flavonoid merupakan senyawa antioksidan yang terdapat dalam gel lidah buaya yang bermanfaat bagi kesehatan, karena bersifat hipoglikemik maupun hipolipidemik. Namun konsumsi gel dalam bentuk segar kurang praktis dan tidak disukai, sehingga harus diolah menjadi makanan. Pengolahan minuman gel lidah buaya telah dilakukan oleh Aloe Ku atau asosiasi petani lidah buaya di Ghra Sambiroto, Nanggulan, Kulon Progo, DIY. Produk tersebut diolah melalui tahap pemotongan dan pemanasan, sehingga sifat antioksidatif gel berkurang. Hasil observasi menunjukkan bahwa minuman gel lidah buaya di Ghra Sambiroto aktivitas antioksidannya belum optimal. Tujuan kegiatan ini adalah menerapkan perbaikan pengolahan minuman gel lidah buaya agar aktivitas antioksidatifnya tinggi. Pelatihan dilakukan dengan penyuluhan, praktek, pendampingan, dan evaluasi pengetahuan dan kemampuan. Hasilnya menunjukkan bahwa terdapat peningkatan ketrampilan mengolah minuman gel lidah buaya berdasarkan korelasi Pearson antara 0,7302–0,9467. Minuman gel lidah buaya memiliki karakteristik gula total 13,35%; kekerasan gel dengan gaya yang dapat ditahan 96,25 g/cm2 dan deformasi 2,81 mm serta kemampuan menangkap radikal bebas (Radical Scavenging Activity), RSA) 6,72%.
Piloting puberty content books and a teacher training guide in Sierra Leone: a qualitative assessment
Authors: Martinez Susi , Marfo Sylvia Ohene , Ibrahim Aisha Fofana , Carney Allison , Vavrus Frances , Kabba Mohamed , Wyss Natalie , Sommer Marni 
Published: September 2024

IntroductionEnsuring young people receive adequate information and guidance about puberty is essential for healthy adolescent transitions. Although many countries are moving toward including comprehensive sexuality education in national curricula, content on puberty during early adolescence, including peer pressure and stigma related to physical and emotional changes, are rarely included. Limited evidence exists about the inclusion of puberty education in schools, and the role of teachers in delivering such content in low-and middle-income countries, including Sierra Leone.MethodsWe conducted a qualitative assessment using multiple methodologies (in-depth interviews with teachers; focus group discussions with girls and boys; key informant interviews with teacher training lecturers and government) to explore the feasibility and acceptability of a puberty education package (a teacher training guide and boys’ and girls’ puberty books) for primary school teachers to introduce puberty content in Sierra Leone.ResultsThree key themes were identified, including the importance of teacher comfort in discussing puberty, the value of the teacher’s guide for delivering puberty content, and system and resource constraints that impact the implementation of puberty education. Additional insights included how integrating puberty education into existing curriculum courses may be more effective than stand-alone puberty classes; education systems can enable in-service and pre-service teacher training, along with culturally appropriate puberty resources, to increase effective puberty education delivery in schools; and governments serve a key role in providing puberty education teacher training, ensuring sustainable funding to retain trained teachers, and offering guidance on national curriculum requirements on puberty education.DiscussionThere is a strong need to integrate puberty education into formal educational systems, with well trained teachers serving a valuable role in its delivery. Research is needed on how best to scale sustainable teacher training interventions to support the delivery of puberty education to adolescents in low- and middle-income contexts.
Effect of pioglitazone on inflammatory response and clinical outcome in T2DM patients with COVID-19: a randomized multicenter double-blind clinical trial
Authors: Baagar Khaled , Alessa Thamer , Abu-Farha Mohamed , Abubaker Jehad , Alhumaidi Heba , Franco Ceruto Jose Antonio , Hamad Mohammad Khair , Omrani Ali , Abdelrahman Salma , Zaka-Ul Haq Muhammad , Safi Abdul Wajid , Alhariri Bassem , Barman Manish , Abdelmajid Alaaeldin , Cancio Humberto Vidal Denis , Elmekaty Eman , Al-Khairi Irina , Cherian Preethi , Jayyousi Lina , Ahmed Mohammed , Qaddoumi Mohammed , Hajji Sulaiman , Esmaeel Ahmad , Al-Andaleeb Ali , Channanath Arshad , Devarajan Sriraman , Ali Hamad , Thanaraj Thangavel Alphonse , Al-Sabah Salman , Al-Mulla Fahd , Abdul-Ghani Muhammad , Jayyousi Amin 
Published: September 2024

BackgroundCoronavirus disease 2019 (COVID-19) caused by the coronavirus SARS-CoV-2, has emerged as a rapidly spreading contagious disease across the globe. Recent studies showed that people with diabetes mellitus, severe obesity, and cardiovascular disease are at higher risk of mortality from COVID-19. It has been suggested that the increased risk is due to the chronic inflammatory state associated with type 2 diabetes. This study aimed to evaluate the efficacy of pioglitazone, a strong insulin sensitizer with anti-inflammatory properties, in improving the clinical outcomes of patients with type 2 diabetes admitted with moderate–severe COVID-19.MethodWe enrolled 350 patients with type 2 diabetes who were admitted to hospitals in Qatar and Kuwait with COVID-19. Patients were randomized to receive, in a double-blind fashion, pioglitazone (n = 189) or a matching placebo (n = 161) for 28 days. The study had two primary outcomes: (1) the incidence of a composite outcome composed of (a) the requirement for mechanical ventilation, (b) death, and (c) myocardial damage; and (2) an increase in C-reactive protein (CRP) levels.ResultsThe first primary outcome occurred in 28 participants (8%), and the secondary outcome occurred in 17. Treatment with pioglitazone showed a significant reduction in interleukin (IL)-3 levels compared with placebo treatment (mean (SD) 2.73 (± 2.14) [95% CI: 0.02, 1.1], p = 0.043 vs. 2.28 (± 1.67) [95% CI: − 0.23, 0.86], p = 0.3, respectively), with no effect seen in the levels of other inflammatory markers. Even though not significant, a few of the patients on pioglitazone exhibited serum troponin levels &gt; 3 times higher than the normal range seen in patients on placebo. On the other hand, more patients on pioglitazone were admitted to the ICU than those with placebo, and no significant difference in the CRP reduction was observed between the two groups.ConclusionThe results of the present study demonstrate that pioglitazone treatment did not independently provide any additional clinical benefit to patients with type 2 diabetes admitted with a COVID-19 infection.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT04604223.
RNA editing in response to COVID-19 vaccines: unveiling dynamic epigenetic regulation of host immunity
Authors: Jin Yun-Yun , Liang Ya-Ping , Pan Jia-Qi , Huang Wen-Hao , Feng Yan-Meng , Sui Wei-Jia , Yu Han , Tang Xiao-Dan , Zhu Lin , Chen Jian-Huan 
Published: September 2024

BackgroundCOVID-19 vaccines are crucial for reducing the threat and burden of the pandemic on global public health, yet the epigenetic, especially RNA editing in response to the vaccines remains unelucidated.ResultsOur current study performed an epitranscriptomic analysis of RNA-Seq data of 260 blood samples from 102 healthy and SARS-CoV-2 naïve individuals receiving different doses of the COVID-19 vaccine and revealed dynamic, transcriptome-wide adenosine to inosine (A-to-I) RNA editing changes in response to COVID-19 vaccines (RNA editing in response to COVID-19 vaccines). 5592 differential RNA editing (DRE) sites in 1820 genes were identified, with most of them showing up-regulated RNA editing and correlated with increased expression of edited genes. These deferentially edited genes were primarily involved in immune- and virus-related gene functions and pathways. Differential ADAR expression probably contributed to RNA editing in response to COVID-19 vaccines. One of the most significant DRE in RNA editing in response to COVID-19 vaccines was in apolipoprotein L6 (APOL6) 3’ UTR, which positively correlated with its up-regulated expression. In addition, recoded key antiviral and immune-related proteins such as IFI30 and GBP1 recoded by missense editing was observed as an essential component of RNA editing in response to COVID-19 vaccines. Furthermore, both RNA editing in response to COVID-19 vaccines and its functions dynamically depended on the number of vaccine doses.ConclusionOur results thus underscored the potential impact of blood RNA editing in response to COVID-19 vaccines on the host’s molecular immune system.
The efficacy and safety of probiotics in the adjuvant treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials
Authors: Zhu Yiran , Xu Fan , Chen Hao , Zheng Quanhui 
Published: September 2024

BackgroundIt has been reported that the imbalance of gut microbiota is involved in the pathogenesis of psoriasis. We retrieved randomized placebo-controlled trials to evaluate the efficacy and safety of probiotic administration in the treatment of psoriasis.MethodsThe outcomes were changes in Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), and serum inflammatory indicators after treatment, and adverse events (AEs). Risk ratios (RRs) and mean differences (MDs) were calculated using random or fixed effects model.ResultsSeven qualified studies were identified in our study. The pooled percentage of patients with ≥75% reduction from baseline in PASI was higher in the probiotic group than that in the placebo group (33.57% vs. 23.61%; RR 1.40, 95% CI 0.98–1.98, p = 0.06). Compared with the placebo group, the PASI (MD −3.09, 95% CI −5.04 to −0.74, p = 0.01) and CRP level (MD −2.36, 95% CI −2.77 to −1.95, p &lt; 0.0001) were significantly reduced in the probiotic group. There was no significant difference in DLQI (MD −1.45, 95% CI −6.72 to 3.82, p = 0.59) and AEs (RR 0.68, 95% CI 0.37–1.25, p = 0.22) between the two groups.ConclusionOral administration of probiotics can improve psoriasis; however, large randomized controlled trials are needed to support this conclusion.Systematic review registrationPROSPERO, identifier CRD42024506286, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024506286.
Structure and assembly process of skin fungal communities among bat species in northern China
Authors: Wang Denghui , Wang Fan , Huang Zihao , Li Aoqiang , Dai Wentao , Leng Haixia , Jin Longru , Li Zhongle , Sun Keping , Feng Jiang 
Published: September 2024

BackgroundThe skin fungal communities of animals play a crucial role in maintaining host health and defending against pathogens. Because fungal infections can affect the skin microbiota of bats, gaining a comprehensive understanding of the characteristics of healthy bat skin fungal communities and the ecological processes driving them provides valuable insights into the interactions between pathogens and fungi.MethodsWe used Kruskal–Wallis tests and Permutational Multivariate Analysis of Variance (PERMANOVA) to clarify differences in skin fungal community structure among bat species. A Generalized Linear Model (GLM) based on a quasi-Poisson distribution and partial distance-based redundancy analysis (db-RDA) was performed to assess the influence of variables on skin fungal communities. Using community construction models to explore the ecological processes driving fungal community changes, t-tests and Wilcoxon tests were used to compare the alpha diversity and species abundance differences between the fungal structure on bat species’ skin and the environmental fungal pool.ResultsWe found significant differences in the composition and diversity of skin fungal communities among bat species influenced by temperature, sampling site, and body mass index. Trophic modes and skin fungal community complexity also varied among bat species. Null model and neutral model analysis demonstrated that deterministic processes dominated the assembly of skin fungal communities, with homogeneous selection as the predominant process. Skin fungal communities on bat species were impacted by the environmental fungal reservoir, and actively selected certain amplicon sequence variants (ASVs) from the environmental reservoir to adhere to the skin.ConclusionIn this study, we revealed the structure and the ecological process driving the skin fungal community across bat species in northern China. Overall, these results broaden our knowledge of skin fungal communities among bat species, which may be beneficial to potential strategies for the protection of bats in China.
Horizontal analysis and longitudinal cohort study of chronic renal failure correlates and cerebral small vessel disease relationship using peak width of skeletonized mean diffusivity
Authors: Wang Dan , Sun Zheng , Li Yuehua 
Published: September 2024

Background and purposePeak width of skeletonized mean diffusivity (PSMD) is an MRI-based biomarker that may reflect white matter lesions (WML). PSMD is based on skeletonization of MR DTI data and histogram analysis. Both chronic renal failure (CRF) and WML may be affected by multisystemic small-vessel disorder. We aimed to explore the relationship between PSMD and estimated glomerular filtration rate (eGFR).MethodsFifty followed-up CRF patients matched for age, sex, hypertension and smoking status were enrolled and classified into a progressive group (n = 16) and stable group (n = 34) based on eGFR levels. Longitudinal and horizontal differences of PSMD were compared between the progressive and stable groups at the initial and follow-up time points. Pearson’s correlation was used for correlation of eGFR with PSMD and WML (per Fazekas scale score). ROC was used to measure the sensitivity of PSMD and WML score to changes of eGFR.ResultsAt the follow-up time point, PSMD of the progressive group was significantly higher than at the initial time point (p &lt; 0.001), and PSMD of the progressive group was significantly higher than stable group (p &lt; 0.001). PSMD and eGFR were significantly correlated. AUC curves explored that ΔPSMD (PSMD changes at the follow-up and initial time points) and follow-up PSMD was better for the classification of progressive and stable groups.ConclusionPSMD has significant correlation with eGFR, PSMD can reveal a close relationship between WML and CRF.
Sex differences in functional and structural alterations of hippocampus region in chronic pain: a DTI and resting-state fMRI study
Authors: Zhou Jun-Zhi , Deng Jie , Luo De-Xing , Mai Jing-Wen , Wu Jia-Yan , Duan Yu-Juan , Dong Bo , Xin Wen-Jun , Xu Ting , Wei Jia-You 
Published: September 2024

IntroductionIt is well known that there are significant differences in the prevalence of chronic pain between males and females. Human and animal imaging studies have shown that chronic pain profoundly alters the structure and function of brain regions. However, there is limited research on the sex-specific mechanisms underlying the brain plasticity and adaptive changes associated with chronic pain. In this article, we conducted a multimodal study to evaluate how nerve injury-induced chronic pain affects the brain.MethodsMale and female Sprague-Dawley (SD) rats with spared nerve injury (SNI) model underwent resting-state functional magnetic resonance imaging (rs-fMRI) (male sham group: n = 18; male SNI group: n = 18; female sham group: n = 20; female SNI group: n = 18) and magnetic resonance diffusion tensor imaging (DTI) (male sham group: n = 23; male SNI group: n = 21; female sham group: n = 20; female SNI group: n = 21) scanning. ICA method, Fractional amplitude of low-frequency fluctuations (fALFF), immunofluorescence staining, and graph theory analysis was utilized to extract the rs-fMRI changes of brain regions of each group.ResultsUsing SNI model, which promotes long-lasting mechanical allodynia, we found that neuropathic pain deeply modified the intrinsic organization of the brain functional network in male and female rats (main effect of operation: F = 298.449, P &lt; 0.001). 64 independent components (ICs) in the brain were divided and assigned to 16 systems. In male rats, we observed significant alterations in the microstructure of the hippocampal cornu ammonis 1 and cornu ammonis 2 (CA1/CA2) region, as indicated by increased mean diffusivity (MD) (CA1_L: P = 0.02; CA1_R: P = 0.031; CA2_L: P = 0.035; CA2_R: P = 0.015) and radial diffusivity (RD) (CA1_L: P = 0.028; CA1_R: P = 0.033; CA2_L: P = 0.037; CA2_R: P = 0.038) values, along with enhanced activating transcription factor 3 (ATF3) expression. Conversely, in female rats, we found significant increases in the fractional amplitude of low frequency fluctuations (fALFF) value within the hippocampal dentate gyrus (DG) (F = 5.419, P = 0.023), accompanied by elevated c-Fos signal (F = 6.269, P = 0.031). Furthermore, graph theory analysis revealed notable differences in the small-world network of the hippocampal system in female rats, characterized by reduced small-world attributes and increased inter-nodal transmission efficiency.DiscussionOur study indicates sex differences in structural and functional alterations in the hippocampal system in rats under chronic pain conditions. The results suggest that the hippocampus system plays an important role in the different mechanisms of chronic pain in different sexes. These findings provide reliable insights to explore the complex mechanisms underlying sex differences in chronic pain.
Ultra-processed foods intake and sex hormone levels among children and adolescents aged 6–19 years: a cross-sectional study
Authors: Zhao Hao , Gui Wei , Liu Shangtao , Zhao Fangyu , Fan Wenyan , Jing Fangyuan , Sun Chuan 
Published: September 2024

BackgroundSex hormones are crucial for the development of children and adolescents. The increasing consumption of ultra-processed foods (UPFs) among children and adolescents in the United States (US) has raised concerns about their potential impact on health, including hormonal balance.MethodsData from 3,354 participants aged 6–19 years from the NHANES 2013–2016 were analyzed. UPF intake was categorized using the NOVA food classification system, and the percentage of total daily energy intake from UPFs was calculated. The serum levels of total testosterone (TT), sex hormone-binding globulin (SHBG), and estradiol (E2) were measured. The free androgen index (FAI) and TT/E2 ratio were calculated to estimate bioavailable testosterone levels and the balance between androgens and estrogens, respectively. Multiple linear regression models, adjusted for potential confounders, estimated the associations.ResultsOur results showed that higher intake of UPFs was marginally associated with decreased serum SHBG levels (quartile (Q) 2 vs. Q1: β = −5.3, 95% confidence interval (CI): −17.0, 8.1%; Q3 vs. Q1: β = −14.6, 95%CI: −25.1, −2.5%; Q4 vs. Q1: β = −9.0, 95%CI: −20.3, 3.8%; P trend = 0.081), and significantly associated with increased serum FAI in female adolescents (Q2 vs. Q1: β = 3.2, 95%CI: −3.3, 9.7; Q3 vs. Q1: β = 7.6, 95%CI: −0.7, 16.0; Q4 vs. Q1: β = 9.5, 95%CI: 1.5, 17.6; P trend = 0.019). Additionally, UPF intake showed a marginally positive association with increased serum SHBG levels (P trend = 0.057) in male children and FAI (P trend = 0.150) in male adolescents, respectively. Similar results were observed when participants were stratified by puberty status, except for the association between UPF intake and SHBG in male children. However, there were no associations between UPF consumption and TT, E2, or the TT/E2 ratio, both in males and females.ConclusionHigher UPF consumption is associated with increased FAI in adolescents, particularly in girls, indicating higher bioavailable testosterone levels. Future studies should validate these findings with direct free testosterone measurements and more precise dietary intake assessments.
A novel tool for predicting the risk of cancer-specific early death in older patients with primary malignant melanoma of skin: a population-based analysis
Authors: Lei Yan , Wang Shucui , Chen Jun , Liu Lanjun , Huang Linting , Wu Xiujuan , Xu Hui , Yang Yali 
Published: September 2024

BackgroundPrimary malignant melanoma (MM) of skin threatens health, especially in the older population, causing a significant risk of early death. The purpose of this study was to establish a diagnostic nomogram to predict the early mortality risk in older patients with primary skin MM and to determine the independent risk factors of cancer-specific early death in such patients.MethodsThe Surveillance, Epidemiology and End Results (SEER) database provided the clinical and pathological characteristics of older patients with primary skin MM from 2000 to 2019. Initially, a 7:3 random assignment was used to place the recruited patients into training and validation cohorts. Then, the independent risk variables of cancer-specific early death in those individuals were determined using univariate and multivariate logistic regression analysis. Those patients’ diagnostic nomograms were constructed using the acquired independent risk variables. Ultimately, the performance of the newly created diagnostic nomogram was verified using calibration curves, receiver operating characteristic (ROC), and decision curve analysis (DCA) curves.ResultsIn this study, 2,615 patients in total were included. Age, histology, liver metastasis, tumor stage, surgery, therapy, and radiation were found to be independent risk factors following statistical analysis, with a special emphasis on early death in older patients with primary skin MM. A diagnostic nomogram for the cancer-specific early death risk was created and validated based on these variables. High agreement was reported between the expected and actual probabilities in the calibration curves. Area under the curves (AUC) of the novel created diagnostic nomogram was greater than that of each independent risk factor, with AUCs for the training and validation cohorts being 0.966 and 0.971, respectively. The nomogram had a high value for its applicability in clinical settings, according to DCA.ConclusionIn older patients with primary skin MM, the current study created a diagnostic nomogram to predict the probability of cancer-specific early death. Because of the nomograms’ good performance, physicians will be better able to identify older patients who are at a high risk of early death and treat them individually to increase their survival benefit.