bluuebunny/crossref_metadata_2025_split huggingface dataset:
DICS Music Therapy: Databases and Data Communication
Authors: van den Berk Pieter , Vodegel Frans , Wigram Tony 
Published: January 2016

In introducing this paper on the Documentary Information and Communication System which has been developed over the last two and a half years in the Netherlands, I find it difficult to hide the excitement and enthusiasm I feel for this project and for the men who have pioneered such an important development for music therapy. I have been to four different presentations by Pieter van den Berk and Frans Vodegel and recently spent time in the Netherlands with them discussing how the system can be established in the UK, and how it is being established in other countries. The tremendous value of this resource to music therapy is almost incalculable. Communication is one of the most fundamental elements in music therapy practice, and the essence of this paper is in describing a process by which music therapists can communicate with each other all over the world. Imagine a situation where after initiating some work with somebody suffering from a particular problem, you experience considerable difficulties in how to proceed. Through the DICS, it would be quite simple to delve into the memory of the computer, and quickly find out all the other practitioners in countries which have established the system who are involved or have been involved in the same area of work, and make contact with them. Additionally, the system will allow us to call up available literature on particular problems that we are working with in music therapy journals and medical journals that have been stored in the system. Personally, I will find it enormously valuable to establish and build up contact with music therapists all over Europe and in the United States and in Australia who are working in the same area that I am. But the DICS is not only a process of taking, it is also a process of giving. By giving information to the system about music therapy in Great Britain, training, clinical practice and available literature, we will find that not only can we gain from understanding the work of others, but can take pride in the dissemination of our own work abroad.
Interpretation of the QuickDASH score after open carpal tunnel decompression: threshold values associated with patient satisfaction
Authors: Clement N. D. , Duckworth A. D. , Jenkins P. J. , McEachan J. E. 
Published: January 2016

We studied the correlation between change in the QuickDASH score and the absolute post-operative QuickDASH score with patient satisfaction after open carpal tunnel decompression. Threshold values in the QuickDASH score, the point at which the sensitivity and specificity are maximal in predicting patient satisfaction, were identified. During the study period, outcome data were compiled for 937 carpal tunnel decompressions, which included 219 (23%) male and 718 (77%) female patients with a mean age of 58 years (standard deviation (SD) 14). There was a significant improvement (mean difference 32, 95% confidence interval (CI) 30 to 34) in the QuickDASH from a mean of 54 (SD 20) to 22 (SD 23) at 1 year after surgery. There were 808 (86%) patients who defined their outcome as satisfactory at 1 year. The identified threshold values for the post-operative QuickDASH score (⩽34 points) and the change (⩾20 points) in the score were highly predictive of patient satisfaction. However, these threshold values varied significantly according to the baseline pre-operative score. The threshold values identified in the QuickDASH can be used to interpret the score. However, the influence of the pre-operative baseline score should be taken into account when comparing different cohorts of patients or using the values to power future studies. Level of Evidence IV: Prognosis, observational cohort study
Effectiveness of long-acting antipsychotics in clinical practice: 2. Effects of antipsychotic polypharmacy on risperidone long-acting injection and zuclopenthixol decanoate
Authors: Cordiner Matthew , Shajahan Polash , McAvoy Sarah , Bashir Muhammad , Taylor Mark 
Published: January 2016

Objectives: Antipsychotic polypharmacy (APP) is common clinical practice. Theoretically, APP runs the risk of additional side effects, drug interactions, adherence and cost. A limited evidence base is emerging to support the effectiveness of APP in clinical practice. Our companion paper highlighted the extent of APP alongside commonly prescribed long-acting antipsychotic injections (LAIs). We aimed to examine the effects of APP on discontinuation rates and Clinical Global Impression (CGI) outcomes in patients commenced on risperidone long-acting injection (RLAI) and zuclopenthixol decanoate. Method: LAI-naïve patients commenced on RLAI ( n = 102) and zuclopenthixol decanoate( n = 105) were identified using our electronic patient record (running from 2002) within NHS Lanarkshire, Scotland, UK. This was a retrospective, electronic case note review with an 18-month follow up. Patient groups were divided into those receiving the LAI as the sole antipsychotic and those who were receiving additional oral antipsychotic polypharmacy (APP) for at least 50% of the duration of the treatment with their LAI. Kaplan–Meier statistics were calculated for discontinuation rates. CGI severity and improvement scores were retrospectively assigned by the investigating team. Results: Antipsychotic polypharmacy occurred with RLAI (37%) and zuclopenthixol decanoate (46%) and was associated with lower discontinuation rates (statistical significant with zuclopenthixol for any cause and adverse effects discontinuation). APP had no adverse outcomes on hospital admissions or CGI ratings. Patients on APP did not have more severe, chronic or treatment resistant illnesses. Conclusions: For RLAI and zuclopenthixol decanoate, APP had some favourable outcomes when examining discontinuation rates for any cause, and adverse effects. This was unexpected as we had considered APP would signal illness chronicity and severity and be associated with increased adverse effects resulting in early discontinuation. APP had no adverse outcomes on assigned CGI improvement or mean end-point severity ratings for RLAI and zuclopenthixol decanoate.
A drain- and catheter-free enhanced recovery protocol to achieve discharge within 23 hours of laparoscopic pyeloplasty surgery: Is this feasible and safe?
Authors: Donati-Bourne Jack , Husaini Muhammad Idzwan , Pillai Praveen , Mathias Suresh Jay , Fernando Herman , Luscombe Christopher , Golash Anurag 
Published: January 2016

Objective: The objective of this article is to review the outcomes of our updated single-centre extended experience of an innovative enhanced recovery pathway to perform catheter- and drain-free laparoscopic pyeloplasties, achieving safe discharge within 23 hours of surgery. Patients and methods: We conducted a retrospective review of patients who underwent a standard trans-peritoneal laparoscopic pyeloplasty repair over an antegrade stent in our centre by a single surgeon, between 1 September 2007 and 1 February 2015. Patients who had a urinary catheter and/or peri-nephric drain inserted intraoperatively and were not planned for day-case discharge were excluded. Data were collected for duration of in-patient stay, readmission rates and reasons for these. Successful outcome was deemed both in subjective improvement of patient symptoms and/or objective improvement in post-operative MAG-3 renogram curve. Results: Fifty-eight patients were included. A total of 74% ( n = 43) were successfully discharged as day-case, and four of these were readmitted. Fifteen patients required in-patient stay, of whom two were readmitted. Successful outcome was recorded in 93% ( n = 54). Conclusion: The insertion of a drain and catheter are not essential in laparoscopic pyeloplasty. Avoidance of unnecessary tubes facilitates day-case surgery with no adverse effect on outcome. At our institute all patients are now offered the enhanced recovery protocol for laparoscopic pyeloplasty with resulting benefits both to patients and the local health economy.
Nineveh Revisited: Theory and Practice in Interfaith Relations
Authors: Lamb Christopher 
Published: January 2016

A Christian woman I am in touch with has just discovered that her Pakistani Muslim husband already has a wife and children in Pakistan. How do I counsel her? A group of Muslims want to use our church hall for their coming festival. What should we say? The regional television network wants to make a program about a leader of one of the other faith communities in Britain. Whom do you suggest? The school governors are anxious to maintain the Christian character of the school although it has over 50 percent Muslim, Sikh, and Hindu pupils. What do you advise?
CCRL2 regulates M1/M2 polarization during EAE recovery phase
Authors: Mazzon Cristina , Zanotti Lucia , Wang Li , Del Prete Annalisa , Fontana Elena , Salvi Valentina , Poliani Pietro Luigi , Sozzani Silvano 
Published: January 2016

Abstract
Chemokine (CC motif) receptor-like 2 is a 7-transmembrane protein related to the family of the atypical chemokine receptors, which are proteins devoid of chemotactic activity and involved in the control of inflammation. Experimental autoimmune encephalitis is an autoimmune disorder that replicates the inflammatory aspects of multiple sclerosis. Chemokine (CC motif) receptor-like 2–deficient mice developed exacerbated, nonresolving disease with protracted inflammatory response and increased demyelination. The increased severity of the disease was associated with higher levels of microglia/macrophage activation markers and imbalanced M1/M2 polarization. Thus, chemokine (CC motif) receptor-like 2 is involved in the downregulation of central nervous system–associated experimental autoimmune encephalitis inflammation in the recovery phase of the disease. Therefore chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.
CD26/dipeptidylpeptidase IV—chemokine interactions: double-edged regulation of inflammation and tumor biology
Authors: Mortier Anneleen , Gouwy Mieke , Van Damme Jo , Proost Paul , Struyf Sofie 
Published: January 2016

Abstract
Post-translational modification of chemokines is an essential regulatory mechanism to enhance or dampen the inflammatory response. CD26/dipeptidylpeptidase IV, ubiquitously expressed in tissues and blood, removes NH2-terminal dipeptides from proteins with a penultimate Pro or Ala. A large number of human chemokines, including CXCL2, CXCL6, CXCL9, CXCL10, CXCL11, CXCL12, CCL3L1, CCL4, CCL5, CCL11, CCL14, and CCL22, are cleaved by CD26; however, the efficiency is clearly influenced by the amino acids surrounding the cleavage site and although not yet proven, potentially affected by the chemokine concentration and interactions with third molecules. NH2-terminal cleavage of chemokines by CD26 has prominent effects on their receptor binding, signaling, and hence, in vitro and in vivo biologic activities. However, rather than having a similar result, the outcome of NH2-terminal truncation is highly diverse. Either no difference in activity or drastic alterations in receptor recognition/specificity and hence, chemotactic activity are observed. Analogously, chemokine-dependent inhibition of HIV infection is enhanced (for CCL3L1 and CCL5) or decreased (for CXCL12) by CD26 cleavage. The occurrence of CD26-processed chemokine isoforms in plasma underscores the importance of the in vitro-observed CD26 cleavages. Through modulation of chemokine activity, CD26 regulates leukocyte/tumor cell migration and progenitor cell release from the bone marrow, as shown by use of mice treated with CD26 inhibitors or CD26 knockout mice. As chemokine processing by CD26 has a significant impact on physiologic and pathologic processes, application of CD26 inhibitors to affect chemokine function is currently explored, e.g., as add-on therapy in viral infection and cancer.
Parity of publication for psychiatry
Authors: Vivekanantham Sayinthen , Strawbridge Rebecca , Rampuri Riaz , Ragunathan Thivvia , Young Allan H. 
Published: January 2016

BackgroundThere is an established disparity between physical and mental healthcare. Parity of research outputs has not been assessed internationally across influential medical journals.AimsTo assess parity of publication between physical and mental health, and within psychiatry.MethodFour major medical disciplines were identified and their relative burden estimated. All publications from the highest-impact general medical journals in 2001, 2006 and 2011 were categorised accordingly. The frequency of psychiatry, cardiology, oncology and respiratory medicine articles were compared with the expected proportion (given illness burdens). Six subspecialties within psychiatry were also compared.ResultsPsychiatry was consistently and substantially underrepresented; other specialties were overrepresented. Dementia and psychosis demonstrated overrepresentation, with addiction and anxiety disorders represented proportionately and other disorders underrepresented. The underrepresentation of mood disorders increased more recently.ConclusionsThere appears to be an important element of disparity of esteem; further action is required to achieve equivalence between mental and physical health research publications.
Research Resource: Genetic Labeling of Human Islet Alpha Cells
Authors: Pauerstein Philip T. , Park Keon Min , Peiris Heshan S. , Wang Jing , Kim Seung K. 
Published: January 2016

AbstractThe 2 most abundant human pancreatic islet cell types are insulin-producing β-cells and glucagon-producing α-cells. Defined cis-regulatory elements from rodent Insulin genes have permitted genetic labeling of human islet β-cells, enabling lineage tracing and generation of human β-cell lines, but analogous elements for genetically labeling human α-cells with high specificity do not yet exist. To identify genetic elements that specifically direct reporter expression to human α-cells, we investigated noncoding sequences adjacent to the human GLUCAGON and ARX genes, which are expressed in islet α-cells. Elements with high evolutionary conservation were cloned into lentiviral vectors to direct fluorescent reporter expression in primary human islets. Based on the specificity of reporter expression for α- and β-cells, we found that rat glucagon promoter was not specific for human α-cells but that addition of human GLUCAGON untranslated region sequences substantially enhanced specificity of labeling in both cultured and transplanted islets to a degree not previously reported, to our knowledge. Specific transgene expression from these cis-regulatory sequences in human α-cells should enable targeted genetic modification and lineage tracing.
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders
Authors: Fieten Hille , Gill Yadvinder , Martin Alan J. , Concilli Mafalda , Dirksen Karen , van Steenbeek Frank G. , Spee Bart , van den Ingh Ted S. G. A. M. , Martens Ellen C. C. P. , Festa Paola , Chesi Giancarlo , van de Sluis Bart , Houwen Roderick H. J. H. , Watson Adrian L. , Aulchenko Yurii S. , Hodgkinson Victoria L. , Zhu Sha , Petris Michael J. , Polishchuk Roman S. , Leegwater Peter A. J. , Rothuizen Jan 
Published: January 2016

ABSTRACT
The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving ATP7A, is a fatal neurodegenerative disorder of copper deficiency. Mutations in ATP7B lead to Wilson disease, which is characterized by a predominantly hepatic copper accumulation. The low incidence and the phenotypic variability of human copper toxicosis hamper identification of causal genes or modifier genes involved in the disease pathogenesis. The Labrador retriever was recently characterized as a new canine model for copper toxicosis. Purebred dogs have reduced genetic variability, which facilitates identification of genes involved in complex heritable traits that might influence phenotype in both humans and dogs. We performed a genome-wide association study in 235 Labrador retrievers and identified two chromosome regions containing ATP7A and ATP7B that were associated with variation in hepatic copper levels. DNA sequence analysis identified missense mutations in each gene. The amino acid substitution ATP7B:p.Arg1453Gln was associated with copper accumulation, whereas the amino acid substitution ATP7A:p.Thr327Ile partly protected against copper accumulation. Confocal microscopy indicated that aberrant copper metabolism upon expression of the ATP7B variant occurred because of mis-localization of the protein in the endoplasmic reticulum. Dermal fibroblasts derived from ATP7A:p.Thr327Ile dogs showed copper accumulation and delayed excretion. We identified the Labrador retriever as the first natural, non-rodent model for ATP7B-associated copper toxicosis. Attenuation of copper accumulation by the ATP7A mutation sheds an interesting light on the interplay of copper transporters in body copper homeostasis and warrants a thorough investigation of ATP7A as a modifier gene in copper-metabolism disorders. The identification of two new functional variants in ATP7A and ATP7B contributes to the biological understanding of protein function, with relevance for future development of therapy.
The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders
Authors: Overeem Arend W. , Posovszky Carsten , Rings Edmond H. M. M. , Giepmans Ben N. G. , van IJzendoorn Sven C. D. 
Published: January 2016

ABSTRACT
Congenital diarrheal disorders are rare, often fatal, diseases that are difficult to diagnose (often requiring biopsies) and that manifest in the first few weeks of life as chronic diarrhea and the malabsorption of nutrients. The etiology of congenital diarrheal disorders is diverse, but several are associated with defects in the predominant intestinal epithelial cell type, enterocytes. These particular congenital diarrheal disorders (CDDENT) include microvillus inclusion disease and congenital tufting enteropathy, and can feature in other diseases, such as hemophagocytic lymphohistiocytosis type 5 and trichohepatoenteric syndrome. Treatment options for most of these disorders are limited and an improved understanding of their molecular bases could help to drive the development of better therapies. Recently, mutations in genes that are involved in normal intestinal epithelial physiology have been associated with different CDDENT. Here, we review recent progress in understanding the cellular mechanisms of CDDENT. We highlight the potential of animal models and patient-specific stem-cell-based organoid cultures, as well as patient registries, to integrate basic and clinical research, with the aim of clarifying the pathogenesis of CDDENT and expediting the discovery of novel therapeutic strategies.
Sustainable commercialization of new crops for the agricultural bioeconomy
Authors: Jordan N.R. , Dorn K. , Runck B. , Ewing P. , Williams A. , Anderson K.A. , Felice L. , Haralson K. , Goplen J. , Altendorf K. , Fernandez A. , Phippen W. , Sedbrook J. , Marks M. , Wolf K. , Wyse D. , Johnson G. 
Published: January 2016

Abstract
Diversification of agroecological systems to enhance agrobiodiversity is likely to be critical to advancing environmental, economic, and social sustainability of agriculture. Temperate-zone agroecological systems that are currently organized for production of summer-annual crops can be diversified by integration of fallow-season and perennial crops. Integration of such crops can improve sustainability of these agroecological systems, with minimal interference with current agricultural production. Importantly, these crops can provide feedstocks for a wide range of new bio-products that are forming a new agricultural bioeconomy, potentially providing greatly increased economic incentives for diversification. However, while there are many fallow-season and perennial crops that might be used in such a “bioeconomic” strategy for diversification, most are not yet well adapted and highly-marketable. Efforts are underway to enhance adaptation and marketability of many such crops. Critically, these efforts require a strategic approach that addresses the inherent complexity of these projects. We outline a suitable approach, which we term “sustainable commercialization”: a coordinated innovation process that integrates a new crop into the agriculture of a region, while intentionally addressing economic, environmental and social sustainability challenges via multi-stakeholder governance. This approach centers on a concerted effort to coordinate and govern innovation in three critical areas: germplasm development, multifunctional agroecosystem design and management, and development of end uses, supply chains, and markets. To exemplify the approach, we describe an ongoing effort to commercialize a new fallow-season crop, field pennycress (Thlaspi arvense L.).
The effect of mathematical writing activities on 3th grade students' problem solving and posing skills<p>Matematiksel yazma etkinliklerinin 3. Sınıf öğrencilerinin problem çözme ve kurma becerilerine etkisi
Authors: Pilten Gülhiz , Pilten Pusat 
Published: January 2016

<p>The aim of this study was to determine the effect of mathematical writing activities on 3<sup> rd</sup> grade students' mathematical problem solving and posing skills. Therefore this study was done by using quasi-experimental model with pretest-posttest control group. Research was conducted in 2014- 2015 Education Year Spring Semester. The study group of the research consists of totally 66 3<sup>rd</sup> grade students At the experimental group, the activities of 3<sup>rd</sup> grade mathematics curriculum and 3<sup> rd</sup> grade mathematic text book are applied. In addition to these activities, mathematical writing activities put into application to the experimental group. However to the control group only the activities of 3<sup>rd</sup> grade mathematics curriculum and 3<sup>rd</sup> grade mathematic text book are applied. All groups' applications lasted for 8 weeks. As a result of this study, it was seen that, at the end of the experimental processes, there is a meaningful statistical difference between experiment group and control group, among problem solving and problem posing skills of students in experiment’s group favour. This result is supporting the relevant literature.</p><p> </p><p><strong>Özet</strong></p><p>Bu araştırmanın amacı, matematiksel yazma etkinliklerinin, ilkokul 3. sınıf öğrencilerinin matematiksel problem çözme ve kurma becerileri üzerindeki etkilerini belirlemektir. Bu yönüyle çalışmada, ön test-son test kontrol gruplu deneme modeli kullanılmıştır. Çalışma 2014-2015 bahar yarıyılında gerçekleştirilmiş olup çalışma grubunu toplam 66 3. sınıf öğrencisi oluşturmaktadır. Deney grubunda deneysel işlem sürecinde ilköğretim matematik öğretim programında ve ders kitabında ön görülen etkinliklere ek olarak matematiksel yazma etkinlikleri gerçekleştirilmiştir. Kontrol grubunda ise 3. sınıf matematik programı ve ders kitabında yer verilen etkinliklere bağlı kalınmıştır. Uygulamalar 8 hafta sürmüştür. Araştırma sonuçları, deneysel işlem süreci sonunda deney ve kontrol grubunda yer alan öğrencilerin problem çözme ve kurma becerileri bakımından karşılaştırıldığında, deney grubu lehine istatistiksel olarak anlamlı düzeyde bir farklılık olduğunu göstermektedir. Bu sonuç ilgili literatürü destekler niteliktedir.</p>