bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging business model and inter-organizational coordination mechanisms in the Italian wine industry
Authors: Pezzillo Iacono Mario , Esposito Vincenza , Mercurio Lorenzo , Martinez Marcello 
Published: December 2016

Purpose
The aim of this paper is to interpret the concept of a business model from the pattern of coordination mechanisms used by an Italian wine cooperative to manage its inter-organizational relationships.

Design/methodology/approach
The business model is taken as the structure and governance of the relationships between the focal firm and its exchange partners. The empirical analysis is based on a qualitative investigation, analyzing material collected at the Farming Cooperative Gran Cru.

Findings
Several different coordination mechanisms were used to rethink the firm customer value proposition, showing a very complex and dynamic inter-organizational system: process control mechanisms, knowledge suppliers and clan control mechanisms. The combination of mechanisms enables the firm to govern the extreme complexity of external complementarities and interdependence among activities and resources.

Practical implications
The study is particularly helpful to managers because wine entrepreneurs and managers can influence their networks’ features and strategies, as well as the mechanisms for governance of the relationships and extracting customer value.

Originality/value
The study seeks to enrich the debate on the strategy/structure fit by shifting the focus from the organizational to inter-organizational level of analysis. The analysis centers on boundary-spanning relationships between one wine firm and its partners and knowledge suppliers. This perspective brings business model analysis and inter-organizational design closer because variables of the business model – such as customer value – can be seen as combinations of inter-organizational coordination mechanisms.
Induction of labour for suspected macrosomia at term in non‐diabetic women: a systematic review and meta‐analysis of randomized controlled trials
Authors: Magro‐Malosso ER , Saccone G , Chen M , Navathe R , Di Tommaso M , Berghella V 
Published: December 2016

BackgroundSeveral randomized controlled trials (RCTs) compared induction of labour with expectant management in non‐diabetic women with suspected fetal macrosomia.ObjectiveTo evaluate the effects of labour induction for suspected fetal macrosomia.Search strategyLiterature search in electronic databases.Selection criteriaWe included all RCTs of suspected fetal macrosomia comparing labour induction with expectant management in term pregnancy.Data collection and analysisThe primary outcome was the incidence of caesarean delivery.Main resultsFour RCTs, including 1190 non‐diabetic women with suspected fetal macrosomia at term, were analysed. Pooled data did not show a significant difference in incidence of caesarean delivery [relative risk (RR) 0.91, 95% confidence interval (CI) 0.76–1.09], operative and spontaneous vaginal delivery, shoulder dystocia, intracranial haemorrhage, brachial plexus palsy, Apgar score <7 at 5 min, cord blood pH <7, and mean birth weight comparing women who received induction of labour with those who were managed expectantly. The induction group had a significantly lower time to delivery (mean difference −7.55 days, 95% CI −8.20 to −6.89), lower rate of birth weight ≥4000 g (RR 0.50, 95% CI 0.42–0.59) and ≥4500 g (RR 0.21, 95% CI 0.11–0.39), and lower incidence of fetal fractures (RR 0.17, 95% CI 0.03–0.79) compared with expectant management group.ConclusionInduction of labour ≥38 weeks for suspected fetal macrosomia is associated with a significant decrease in fetal fractures, and therefore can be considered as a reasonable option.Tweetable abstract#Induction of labour for #macrosomia improves neonatal outcome.
A Very Unusual Accidental Mechanical Asphyxia of Choking with a Whole Solea Solea
Authors: Busardò Francesco Paolo , Mannocchi Giulio , Pugnetti Paola , Santurro Alessandro , Maggiordomo Aldo , Zaami Simona 
Published: December 2016

AbstractThe case here reported involves a schizophrenic 19‐year‐old girl under treatment with clotiapine, which was well tolerated except for a moderate dry mouth. The woman ingested a whole sole (Solea solea), which caused a very rapid death by choking. A complete autopsy was performed 24 h later, as well as histological and toxicological analysis. At autopsy, the sole was wedged in the esophagus causing a choking ab extrinseco. The fish had a length of 18 cm and a maximum width of 6 cm, weighing 188.7 g. Toxicological analysis detected 0.57 mg/L of clotiapine in blood, which falls within the therapeutic range. The peculiarity of this case is represented by two factors: one is the choking by fish and the second was the adverse affect caused by clotiapine, which induced a condition of dry mouth making the act of swallowing even more difficult, thereby contributing to a very rapid mechanical asphyxia and the death of the young woman.
The Prevalence of Paraphernalia Found at the Scene of Drug‐Related Deaths
Authors: Lozano Jason G. , Healy Nicole L. , Kimberley Molina D. 
Published: December 2016

AbstractMany illicit drugs involve the use of paraphernalia, and the presence of paraphernalia found at the scene of death may suggest that the death is drug‐related. Few sources of objective data are available regarding the prevalence of drug paraphernalia found at the scene of drug‐related deaths or the likelihood of a death with drug paraphernalia found at the scene to be drug‐related. This study reviews the deaths which were investigated by the Bexar County Medical Examiner's Office in an attempt to provide objective data. Over 4000 deaths with scene investigations were reviewed, and the presence of paraphernalia was found to be strongly associated with the death being drug‐related, heroin‐related, or cocaine‐related with the relative risk for each being 5.0, 15.4, and 6.6, respectively. This confirms that the presence of drug paraphernalia at the scene of death strongly suggests the death to be drug‐related and in particular heroin‐related.
The implied equity duration when discounting and forecasting parameters are industry specific
Authors: Fullana Olga , Nave Juan M. , Toscano David 
Published: December 2016

AbstractWe estimate the implied equity duration using industry‐specific parameters. We provide evidence that this procedure improves the ability of implied equity duration to capture stock price risk. We show that it is due to a better capture of both the market risk and residual risk of the market asset pricing model. As expected, the higher the difference in the estimates of duration, the higher the improvement in measuring price risk, but the results also show that the highest improvements are obtained when the usual implied equity duration estimation based on market parameters performs poorly as a price risk measure.
Vulnerability to alcohol‐related problems: a policy brief with implications for the regulation of alcohol marketing
Authors: Babor Thomas F. , Robaina Katherine , Noel Jonathan K. , Ritson E. Bruce 
Published: December 2016

AbstractBackground and AimsThe concern that alcohol advertising can have detrimental effects on vulnerable viewers has prompted the development of codes of responsible advertising practices. This paper evaluates critically the concept of vulnerability as it applies to (1) susceptibility to alcohol‐related harm and (2) susceptibility to the effects of marketing, and describes its implications for the regulation of alcohol marketing.MethodWe describe the findings of key published studies, review papers and expert reports to determine whether these two types of vulnerability apply to population groups defined by (1) age and developmental history; (2) personality characteristics; (3) family history of alcoholism; (4) female sex and pregnancy risk; and (5) history of alcohol dependence and recovery status.ResultsDevelopmental theory and research suggest that groups defined by younger age, incomplete neurocognitive development and a history of alcohol dependence may be particularly vulnerable because of the disproportionate harm they experience from alcohol and their increased susceptibility to alcohol marketing. Children may be more susceptible to media imagery because they do not have the ability to compensate for biases in advertising portrayals and glamorized media imagery.ConclusionYoung people and people with a history of alcohol dependence appear to be especially vulnerable to alcohol marketing, warranting the development of new content and exposure guidelines focused on protecting those groups to improve current self‐regulation codes promoted by the alcohol industry. If adequate protections cannot be implemented through this mechanism, statutory regulations should be considered.
Effects of mineral salt supplement on enteric methane emissions, ruminal fermentation and methanogen community of lactating cows
Authors: Li Xiaohua , Liu Chong , Chen Yongxing , Shi Rongguang , Cheng Zhenhua , Dong Hongmin 
Published: December 2016

AbstractWe evaluated the effects of mineral salt supplement on enteric methane emissions, ruminal fermentation and methanogen community of dairy cows over a whole lactation period. Ten Holstein cows fed a total mixed ration (TMR) diet were randomly allocated into two groups, one supplied with mineral salts as the treatment group and the other as the control group. The methane measurement showed that the ingestion of mineral salts lowered enteric methane emissions significantly (P < 0.05), with an average of 10.5% reduction over the whole lactation period. Ruminal fermentation analysis showed the mineral salt intake could significantly decrease the acetate : propionate ratio (P < 0.05). Real‐time PCR assay showed that rumen methanogen abundance significantly reduced in the treatment group (P < 0.05) but was not significantly influenced by mineral salt intake over the whole lactation period. Intergroup methanogen community composition was influenced slightly by mineral salt intake; however, significantly different intragroup profiles were apparent throughout the whole lactation period, according to denaturing gradient gel electrophoresis analysis. In conclusion, these results suggested that the effective mitigation of enteric methane emissions by mineral salt intake could be attributed to decreased density of methanogenic archaea and that fluctuations in methane emission over the lactation period might be related to Methanobrevibacter diversity.
Cardiac effects of amiselimod compared with fingolimod and placebo: results of a randomised, parallel‐group, phase I study in healthy subjects
Authors: Harada Tomohiko , Wilbraham Darren , de La Borderie Guillemette , Inoue Shinsuke , Bush Jim , Camm A. John 
Published: December 2016

AimAmiselimod (MT‐1303) is a selective sphingosine 1‐phosphate 1 (S1P1) receptor modulator which is currently being developed for the treatment of various autoimmune diseases. Unlike some other S1P receptor modulators, amiselimod seemed to show a favourable cardiac safety profile in preclinical, phase I and II studies. The aim of the current study was to characterize the cardiac effects of amiselimod by directly comparing it with fingolimod and placebo.MethodsA total of 81 healthy subjects aged 18–55 years were equally randomized to receive amiselimod 0.4 mg, amiselimod 0.8 mg, placebo or fingolimod 0.5 mg once daily for 28 days. The chronotropic/dromotropic and inotropic effects were evaluated using intensive Holter electrocardiogram and echocardiography.ResultsUnlike fingolimod, neither amiselimod dose exerted acute (1–6 h) negative chronotropic effects on Days 1 and 2. The lowest nadir mean hourly heart rate was observed on Day 14 in the amiselimod 0.4 mg group (least squares mean difference: −4.40 bpm, 95% confidence interval −7.15, −1.66) and Day 7 in the 0.8 mg group [−3.85 bpm (−6.58, −1.11)] compared with placebo, but these changes were smaller than those with fingolimod on Day 1 [−6.49 bpm (−8.95, −4.02)]. No clinically significant bradyarrhythmia or cardiac functional abnormalities were observed in either amiselimod group. Both amiselimod doses were well tolerated and no serious adverse events were reported. Fingolimod was also generally well tolerated, although one subject was withdrawn owing to highly frequent 2:1 atrioventricular blocks on Day 1.ConclusionThe study demonstrated a more favourable cardiac safety profile for amiselimod than fingolimod when administered over 28 days in healthy subjects.
Intra‐stakeholder alliances in plant‐closing decisions: A stakeholder theory approach
Authors: Fassin Yves , de Colle Simone , Freeman R. Edward 
Published: December 2016

AbstractThis article discusses plant‐closing decisions by multinational enterprises (MNEs) applying a stakeholder theory approach. In particular, we focus on the emergence of “intra‐stakeholder alliances,” that is, alliances among the various stakeholder groups of a specific corporation. We analyze the emergence of stakeholder alliances in reaction to MNEs' decisions to terminate production locally and discuss their influence on the outcomes of such decisions. Our research is inspired by two exceptional case studies of two multinational breweries that announced their decisions to close niche breweries in small towns in Italy and Belgium. In both cases, the initial decision was ultimately reversed through the actions of intra‐stakeholder alliances. We combine insights from stakeholder theory and the social movement literature to analyze the action and influence of intra‐stakeholder alliances in seven cases of plant‐closing decisions. We conclude by formulating four general propositions that can provide guidance to MNE management in plant‐closing decisions. Our findings extend managerial stakeholder theory, show how this approach can improve strategic management analysis, emphasize the importance of the relationships among (local) stakeholders in the (global) value‐creation process, and shed light on the collective action and influence of intra‐stakeholder alliances.
Hydrogen peroxide preferentially activates capsaicin‐sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder
Authors: Nicholas S , Yuan S Y , Brookes S J H , Spencer N J , Zagorodnyuk V P 
Published: December 2016

Background and PurposeThere is increasing evidence suggesting that ROS play a major pathological role in bladder dysfunction induced by bladder inflammation and/or obstruction. The aim of this study was to determine the effect of H2O2 on different types of bladder afferents and its mechanism of action on sensory neurons in the guinea pig bladder.Experimental Approach‘Close‐to‐target’ single unit extracellular recordings were made from fine branches of pelvic nerves entering the guinea pig bladder, in flat sheet preparations, in vitro.Key ResultsH2O2 (300–1000 μM) preferentially and potently activated capsaicin‐sensitive high threshold afferents but not low threshold stretch‐sensitive afferents, which were only activated by significantly higher concentrations of hydrogen peroxide. The TRPV1 channel agonist, capsaicin, excited 86% of high threshold afferents. The TRPA1 channel agonist, allyl isothiocyanate and the TRPM8 channel agonist, icilin activated 72% and 47% of capsaicin‐sensitive high threshold afferents respectively. The TRPA1 channel antagonist, HC‐030031, but not the TRPV1 channel antagonist, capsazepine or the TRPM8 channel antagonist, N‐(2‐aminoethyl)‐N‐[[3‐methoxy‐4‐(phenylmethoxy)phenyl]methyl]thiophene‐2‐carboxamide, significantly inhibited the H2O2‐induced activation of high threshold afferents. Dimethylthiourea and deferoxamine did not significantly change the effect of H2O2 on high threshold afferents.Conclusions and ImplicationsThe findings show that H2O2, in the concentration range detected in inflammation or reperfusion after ischaemia, evoked long‐lasting activation of the majority of capsaicin‐sensitive high threshold afferents, but not low threshold stretch‐sensitive afferents. The data suggest that the TRPA1 channels located on these capsaicin‐sensitive afferent fibres are probable targets of ROS released during oxidative stress.
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell‐driven inflammatory responses
Authors: Delgado‐Maroto Virginia , Falo Clara P , Forte‐Lago Irene , Adan Norma , Morell Maria , Maganto‐Garcia Elena , Robledo Gema , O'Valle Francisco , Lichtman Andrew H , Gonzalez‐Rey Elena , Delgado Mario 
Published: December 2016

Background and purposeMyocarditis is an inflammatory and autoimmune cardiovascular disease that causes dilated myocardiopathy and is responsible for high morbidity and mortality worldwide. Cortistatin is a neuropeptide produced by neurons and cells of the immune and vascular systems. Besides its action in locomotor activity and sleep, cortistatin inhibits inflammation in different experimental models of autoimmune diseases. However, its role in inflammatory cardiovascular disorders is unexplored. Here, we investigated the therapeutic effects of cortistatin in a well‐established preclinical model of experimental autoimmune myocarditis (EAM).Experimental ApproachWe induced EAM by immunization with a fragment of cardiac myosin in susceptible Balb/c mice. Cortistatin was administered i.p. starting 7, 11 or 15 days after EAM induction. At day 21, we evaluated heart hypertrophy, myocardial injury, cardiac inflammatory infiltration and levels of serum and cardiac inflammatory cytokines, cortistatin and autoantibodies. We determined proliferation and cytokine production by heart draining lymph node cells in response to cardiac myosin restimulation.Key ResultsSystemic injection of cortistatin during the effector phase of the disease significantly reduced its prevalence and signs of heart hypertrophy and injury (decreased the levels of brain natriuretic peptide) and impaired myocardial inflammatory cell infiltration. This effect was accompanied by a reduction in self‐antigen‐specific T‐cell responses in lymph nodes and in the levels of cardiomyogenic antibodies and inflammatory cytokines in serum and myocardium. Finally, we found a positive correlation between cardiac and systemic cortistatin levels and EAM severity.Conclusions and ImplicationsCortistatin emerges as a new candidate to treat inflammatory dilated cardiomyopathy.
Differential Third‐Grade Outcomes Associated With Attending Publicly Funded Preschool Programs for Low‐Income Latino Children
Authors: Ansari Arya , Lόpez Michael , Manfra Louis , Bleiker Charles , Dinehart Laura H. B. , Hartman Suzanne C. , Winsler Adam 
Published: December 2016

This study examined the third‐grade outcomes of 11,902 low‐income Latino children who experienced public school pre‐K or child care via subsidies (center‐based care) at age 4 in Miami‐Dade County, Florida. Regression and propensity score analyses revealed that children who experienced public school pre‐K earned higher scores on standardized assessments of math and reading in third grade and had higher grade point averages than those who attended center‐based care 4 years earlier. The sustained associations between public school pre‐K (vs. center‐based care) and third‐grade outcomes were mediated by children's kindergarten entry preacademic and social–behavioral skills, and among English‐language learners, English proficiency. Implications for investing in early childhood programs to assist with the school readiness of young Latino children in poverty are discussed.
Preventive dental visiting: a critical interpretive synthesis of theory explaining how inequalities arise
Authors: Harris Rebecca V. , Pennington Andrew , Whitehead Margaret 
Published: December 2016

AbstractBackgroundIn many countries, those with lower socioeconomic status are disproportionately affected by poor oral health. This can be attributed, at least in part, to differences in preventive dental visiting. While several theories have been applied to the area, they generally fail to capture the recursive nature of dental visiting behaviour, and fall short of informing the design of complex interventions to tackle inequalities.ObjectiveTo undertake a systematic review and synthesis of theory in order to provide an overview of the pathways which bring about socioeconomic inequalities in early dental visiting, and identify possible intervention points.MethodsElectronic searching identified 8947 titles and abstracts. Paper screening and citation snowballing left 77 included papers. Drawing on the tenets of Critical Interpretive Synthesis, data extraction involved capturing concepts and relationships and translating these sometimes into synthetic constructs.ResultsWe theorize that at the individual (micro‐level), dental visiting behaviour is influenced by: the ‘Importance of obtaining care’, ‘Emotional response’ and ‘Perceived control’, which feed into a balancing of ‘Competing Demands’ against ‘Internal resources’ (coping, self‐identity), although attendance is tempered by the effective ‘Affordability and Availability of services’. Positive Care experiences are theorized to lower the demands and increase internal resources associated with dental visiting. We also outline meso‐level factors ‘Social norms and sanctions’, ‘Obligations, expectations and trust’, ‘Information channels’, ‘Social structures’ and theorize how these can exert an overwhelming influence in deprived areas.ConclusionsSocioeconomic inequalities in early dental visiting emerge from several stages in the care‐seeking process. Dental visiting behaviour should be viewed not just as a one‐off event, but extending over time and social space. Since there is recursivity in peoples’ most recent dental experience any future visits we identify that interventions which make care a positive experience for low socioeconomic patients may be particularly beneficial in reducing inequalities.
Oral health status of children in Los Angeles County and in the United States, 1999–2004
Authors: Dye Bruce A. , Vargas Clemencia M. , Fryar Cheryl D. , Ramos‐Gomez Francisco , Isman Robert 
Published: December 2016

AbstractObjectiveTo ascertain and compare the oral health status and related sociodemographic risk indicators in children in Los Angeles (LA) County with children in the United States.MethodsData from the National Health and Nutrition Examination Survey (NHANES) 1999–2004 were used to calculate prevalence estimates for children aged 2–13 years living in LA County and in the United States. Sociodemographic indicators were evaluated using multiple logistic regression modeling.ResultsOverall, children in LA County were more likely to experience dental caries than children in the United States in 1999–2004. In the primary dentition, nearly 40% of preschool children residing in LA County had dental caries compared to 28% of same‐age children in the United States. Among children aged 6–13, 44% living in LA County had dental caries in the permanent dentition compared to 27% in the United States. Mexican American children in LA County had higher caries experience in permanent teeth (but not in primary teeth) than US Mexican American children. Among children aged 6–9 years, there was no difference in the prevalence of dental sealants in permanent teeth between those living in LA County and in the United States. However, among children aged 10–13 years, dental sealants were more than twice as prevalent in US children (40.8%) than in LA County children (17.5%). Among LA County children, the adjusted odds of having caries experience or untreated dental caries in permanent teeth were not higher among children from lower income families than in lower income children in the United States.ConclusionsChildren residing in LA County had less favorable oral health than children in the United States in 1999–2004. The usual sociodemographic caries risk indicators identified among children in the United States were not consistently observed among children in LA County. Unlike in the wider United States, poverty was not a risk indicator for dental caries in older children in LA County.