bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol inhibits ovarian tumor growth in an in vivo mouse model
Authors: Tan Lijun , Wang Weimin , He Gong , Kuick Rork D. , Gossner Gabrielle , Kueck Angela S. , Wahl Heather , Opipari Anthony W. , Liu J. Rebecca 
Published: November 2015

BACKGROUNDResveratrol inhibits the growth of ovarian carcinoma cells in vitro through the inhibition of glucose metabolism and the induction of both autophagy and apoptosis. In the current study, we investigated the metabolic and therapeutic effects of resveratrol in vivo.METHODSA fluorescent xenograft mouse model of ovarian cancer was used. Mice were treated with cisplatin, resveratrol, or vehicle alone. Tumor burden was assessed using whole‐body imaging. The effect of resveratrol on glucose uptake in vivo was determined using micro‐positron emission tomography scanning. To determine whether resveratrol could inhibit tumor regrowth, tumor‐bearing mice were treated with cisplatin followed by either daily resveratrol or vehicle. Autophagic response in resected tumors taken from mice treated with resveratrol was examined by transmission electron microscopy. Glycolysis and mitochondrial respiration in ovarian tumor cells after treatment with resveratrol was assessed.RESULTSMice treated with resveratrol and cisplatin were found to have a significantly reduced tumor burden compared with control animals (P<.001). Resveratrol‐treated mice demonstrated a marked decrease in tumor uptake of glucose compared with controls. After treatment with cisplatin, “maintenance” resveratrol resulted in the suppression of tumor regrowth compared with mice receiving vehicle alone (P<.01). Tumors resected from mice treated with resveratrol exhibited autophagosomes consistent with the induction of autophagy. Treatment with resveratrol inhibited glycolytic response in ovarian tumor cells with high baseline glycolytic rates.CONCLUSIONSTreatment with resveratrol inhibits glucose uptake and has a significant antineoplastic effect in a preclinical mouse model of ovarian cancer. Resveratrol treatment suppresses tumor regrowth after therapy with cisplatin, suggesting that this agent has the potential to prolong disease‐free survival. Cancer 2016;122:722–729. © 2015 American Cancer Society.
The high incidence of vascular thromboembolic events in patients with metastatic or unresectable urothelial cancer treated with platinum chemotherapy agents
Authors: Tully Christopher M. , Apolo Andrea B. , Zabor Emily C. , Regazzi Ashley M. , Ostrovnaya Irina , Furberg Helena F. , Rosenberg Jonathan E. , Bajorin Dean F. 
Published: November 2015

BACKGROUNDThe current study compared the incidence of vascular thromboembolic events (VTEs) in patients with metastatic or unresectable urothelial carcinoma (UC) who were treated with gemcitabine and carboplatin (GCb); gemcitabine, carboplatin, and bevacizumab (GCbBev); or gemcitabine and cisplatin (GCis).METHODSPatients with UC who were treated with GCbBev on protocol were analyzed prospectively and 2 contemporary control cohorts receiving GCb or GCis were evaluated retrospectively. VTE was defined as either venous or arterial (myocardial infarctions or cerebral vascular accidents) thrombosis. VTEs were considered to be related to treatment if they occurred during treatment or within 4 weeks of the completion of treatment. Associations with chemotherapy regimen were tested using either the Fisher exact test or Kruskal‐Wallis test. Clinical factors associated with VTEs were analyzed using conditional logistic regression stratified by treatment regimen.RESULTSAmong 198 patients, VTEs occurred in 13 of 51 patients treated with GCbBev (26%), 22 of 92 patients treated with GCb (24%), and 8 of 55 patients treated with GCis (15%). Patient characteristics were significantly different between the treatment cohorts in terms of age, prior cystectomy, tumor location near pelvic vessels, Khorana risk group, and receipt of antiplatelet therapy. The incidence of VTE and type of VTE (arterial vs venous) did not differ by type of chemotherapy. Prior cystectomy was associated with an increased risk of VTE (odds ratio, 2.2; 95% confidence interval, 1.0‐4.9 [P = .047]).CONCLUSIONSThe incidence of VTE in Cis‐treated patients was similar to prior reports. However, the VTE rate in Cb‐treated patients was > 20%, a figure not previously defined in patients with UC and higher than expected. This high incidence of both Cis‐related and Cb‐related VTEs warrants greater awareness by treating physicians and deserves further study. Cancer 2016;122:712–721. © 2015 American Cancer Society.
Nickel Bicarbonate Revealed as a Basic Carbonate
Authors: Rincke Christine , Bette Sebastian , Dinnebier Robert E. , Voigt Wolfgang 
Published: November 2015

AbstractA new basic nickel carbonate Ni12(CO3)8(OH)8·(x – 1)H2O or Ni12(CO3)8(OH)6O·xH2O (x = 6–8) was synthesized by two hydrothermal methods. The crystal structure was determined in the cubic space group P$\bar {4}$3m (215) with a = 8.3814(2) Å by laboratory high‐resolution X‐ray powder diffraction with the application of global optimization methods and Rietveld refinement. The crystal structure consists of edge‐linked [NiO6] octahedra and carbonate units that form cages. The interconnected cages form channels filled with disordered water molecules. This causes a zeolite‐like behavior of the water molecules, as shown by thermogravimetric analysis coupled with infrared spectroscopy (TG–IR) and in situ X‐ray powder diffraction experiments up to 300 °C. In addition, the title compound was characterized by elemental analysis, scanning electron microscopy, and Raman and UV/Vis spectroscopy. The title compound was proven to be a pure carbonate and not nickel hydrogen carbonate (PDF 15‐0782), as was assumed before.
A 8‐Hydroxyquinoline‐Cyclodextrin Conjugate as an Efficient Chelating Agent for Cobalt(II) and Nickel(II) in Neutral Aqueous Solution
Authors: Sgarlata Carmelo , Oliveri Valentina , Spencer John 
Published: November 2015

AbstractChelating agents offer a versatile and effective means of removing toxic metal ions from the human body. Mounting evidence suggests that exposure to nickel and cobalt causes a number of adverse nasal/pulmonary health effects, skin hazards and allergies. In this context, the development of chelators that are able to bind nickel and cobalt with high stability constants is clearly crucial. Herein, the interaction of cobalt(II) and nickel(II) with a 8‐hydroxyquinoline‐cyclodextrin conjugate was investigated in aqueous solution at neutral pH. This family of chelator under study is potentially relevant in the treatment of diseases related to metal dyshomeostasis. Stability constants for the cobalt(II) and nickel(II) complexes were determined by competition experiments. The data indicate the formation of stable complexes, which were characterized by spectroscopic techniques. The collected information may provide new insights and suggest further strategies for the development of hydroxyquinoline derivatives for the control of cobalt and nickel toxicity.
Use of Planar Chiral Ferrocenyl­phosphine‐Gold(I) Complexes in the Asymmetric Cycloisomerization of 3‐Hydroxylated 1,5‐Enynes
Authors: Wu Zhiyong , Retailleau Pascal , Gandon Vincent , Voituriez Arnaud , Marinetti Angela 
Published: November 2015

AbstractChiral monodentate phosphines based on ortho‐disubstituted ferrocene units have been prepared and used for the synthesis of gold(I) complexes. These complexes are highly active catalysts for the cycloisomerization of 3‐hydroxy‐1,5‐enynes into bicyclo[3.1.0]hexanones. Their high catalytic activity is ascribed to their structural analogy to the biaryl‐based Buchwald phosphines. This paper discloses the first enantioselective variant of these reactions based on gold catalysis (ee's up to 80 %).
Physical‐Organic Chemistry: A Swiss Army Knife
Authors: Whitesides George M. 
Published: November 2015

Abstract“Physical‐organic chemistry” is the name given to a subfield of chemistry that applies physical‐chemical techniques to problems in organic chemistry (especially problems involving reaction mechanisms). “Physical‐organic” is, however, also a short‐hand term that describes a strategy for exploratory experimental research in a wide range of fields (organic, organometallic, and biological chemistry; surface and materials science; catalysis; and others) in which the key element is the correlation of systematic changes in molecular structure with changes in properties and functions of interest (reactivity, mechanism, physical or biological characteristics). This perspective gives a personal view of the historical development, and of possible future applications, of the physical‐organic strategy.
The Nitric Oxide Prodrug JS‐K Induces Ca2+‐Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells
Authors: Liu Ling , Wang Dongmei , Wang Jiangang , Wang Shuying 
Published: November 2015

ABSTRACTHepatocellular carcinoma is one of the most common and deadly forms of human malignancies. JS‐K, O2‐(2, 4‐dinitrophenyl) 1‐ [(4‐ethoxycarbonyl) piperazin‐1‐yl] diazen‐1‐ium‐1, 2‐diolate, has the ability to induce apoptosis of tumor cell lines. In the present study, JS‐K inhibited the proliferation of HepG2 cells in a time‐ and concentration‐dependent manner and significantly induced apoptosis. JS‐K enhanced the ratio of Bax‐to‐Bcl‐2, released of cytochrome c (Cyt c) from mitochondria and the activated caspase‐9/3. JS‐K caused an increasing cytosolic Ca2+ and the loss of mitochondrial membrane potential. Carboxy‐PTIO (a NO scavenger) and BAPTA‐AM (an intracellular Ca2+ chelator) significantly blocked an increasing cytosolic Ca2+ in JS‐K‐induced HepG2 cells apoptosis, especially Carboxy‐PTIO. Meanwhile, Carboxy‐PTIO and BAPTA‐AM treatment both attenuate JS‐K‐induced apoptosis through upregulation of Bcl‐2, downregulation of Bax, reduction of Cyt c release from mitochondria to cytoplasm and inactivation of caspase‐9/3. In summary, JS‐K induced HepG2 cells apoptosis via Ca2+/caspase‐3‐mediated mitochondrial pathway.
Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells
Authors: Wang Chunmei , Luo Yuan , Lu Jie , Wang Yingchao , Sheng Guangyao 
Published: November 2015

ABSTRACTPolydatin (PD), a component isolated from Polygonum cuspidatum, has various activities such as inhibiting platelet aggregation, lowering level of blood lipid, reducing lipid peroxidation, and so on. However, the antitumor activity of PD has been poorly reported. In the present study, effect of PD on cell proliferation was evaluated by Cell Counting Kit‐8, and cell cycle and apoptosis were investigated by flow cytometry. Meanwhile, the protein expression level of Bc1‐2, Bax, cyclin A, cyclin B, and cyclin D1, which associated with apoptosis and cell cycle were analyzed by Western blotting. Results show that PD could effectively inhibit the growth, arrest cells in S phase, and induce apoptosis of acute monocytic leukemia cell line THP‐1; meanwhile, expression of cyclin D1 and Bc1‐2 decreased significantly, and expression of Bax and cyclin A increased notably. All results suggest that PD maybe a potential therapeutic strategy for acute monocytic leukemia.
Spatiotemporal characteristics of hourly precipitation over central eastern China during the warm season of 1982–2012
Authors: Li Deshuai , Sun Jianhua , Fu Shenming , Wei Jie , Wang Shigong , Tian Fuyou 
Published: November 2015

ABSTRACTAn intensive observational hourly precipitation data set from the China Meteorological Administration was utilized to investigate the changes in precipitation amount, frequency, intensity and duration over central eastern China during the warm season from 1982 to 2012. Ten intensity categories were used to reveal the contributions of precipitation frequency and intensity to the variation of rainfall amount. Moreover, the trends of frequency were also evaluated by comparing the respective contributions of the number and the duration of precipitation events. The main results are as follows: (1) The precipitation amount and intensity both decreased from southeast to northwest China, with two areas of high precipitation frequency located in southwestern and southeastern China. A region of high precipitation duration was found in central China and two lower duration regions were found in southern and northern China. (2) Generally, the extreme heavy rainfall showed a significant increasing trend while the light rainfall showed a significant decreasing trend over central eastern China. Nevertheless, the spatial unevenness was detected and in south and southeast China, significant increasing trends were found, whereas in northeast China and the Sichuan Basin, precipitation amounts showed a declining trend in each precipitation intensity category. (3) The trends of precipitation amount were mainly caused by the variations of precipitation frequency, which had a contribution rate of greater than 95%; however, for the heavy rainfall category, intensity changes were also very important. (4) Increased precipitation frequency was largely caused by the prolonged duration of rainfall events, whereas the decreased frequency was mainly due to the reduction in the number of rainfall events.
Evolution of Chemical Characteristics of Technosols in an Afforested Coal Mine Dump over a 20‐year Period
Authors: Rivas‐Pérez Ivana M. , Fernández‐Sanjurjo María J. , Núñez‐Delgado Avelino , Monterroso Carmen , Macías Felipe , Álvarez‐Rodríguez Esperanza 
Published: November 2015

AbstractCoal mining in areas containing pyritic materials frequently leads to a remarkable impact on the environment because of sulphide oxidation. We studied the evolution of chemical characteristics of Technosols derived from sterile materials, in a lignite mine located in As Pontes (northwest Spain), over a 20‐year period. Three plots, which had different management practices, were selected. The mine spoil was deposited randomly in two of the plots (CSP with low S concentration and CSA with high S concentration), while it was selectively managed in the other one (P206). Twenty years after the first sampling, CSA continued to show the highest acidity (pHwater 3∙7–3∙9), whereas the lowest acidity was that of P206 (pHwater 5∙0). Regarding the surface layer, C increased 1∙1% in P206, 0∙3% in CSP and 0∙2% in CSA. Nitrogen increased 1% in P206. The C/N ratio increased in all plots. Phosphorus, Ca, Mg, K and effective cation exchange capacity decreased in 2002 and experienced a slight increase in 2012. Exchangeable Al and Al saturation increased in CSP and P206 and decreased in CSA. Electric conductivity levels of Ca, Mg, Na, Al and SO42− concentrations decreased in the soil solution in all plots during the 20‐year period. Twenty years after the first monitoring, the plots that were built based on selective management of the mine spoil showed lower acidity and acidity‐derived consequences. These facts confirm the necessity of an appropriate selection of sterile materials, avoiding the placement of pyrite‐rich spoils on the surface or near‐surface zones, which is essential to facilitate proper restoration of this kind of dumping areas. Copyright © 2015 John Wiley & Sons, Ltd.
Anisotropic Lithium Ion Conductivity in Single‐Ion Diblock Copolymer Electrolyte Thin Films
Authors: Aissou Karim , Mumtaz Muhammad , Usluer Özlem , Pécastaings Gilles , Portale Giuseppe , Fleury Guillaume , Cloutet Eric , Hadziioannou Georges 
Published: November 2015

Well‐defined single‐ion diblock copolymers consisting of a Li‐ion conductive poly(styrenesulfonyllithium(trifluoromethylsulfonyl)imide) (PSLiTFSI) block associated with a glassy polystyrene (PS) block have been synthesized via reversible addition fragmentation chain transfer polymerization. Conductivity anisotropy ratio up to 1000 has been achieved from PS‐b‐PSLiTFSI thin films by comparing Li‐ion conductivities of out‐of‐plane (aligned) and in‐plane (antialigned) cylinder morphologies at 40 °C. Blending of PS‐b‐PSLiTFSI thin films with poly(ethylene oxide) homopolymer (hPEO) enables a substantial improvement of Li‐ion transport within aligned cylindrical domains, since hPEO, preferentially located in PSLiTFSI domains, is an excellent lithium‐solvating material. Results are also compared with unblended and blended PSLiTFSI homopolymer (hPSLiTFSI) homologues, which reveals that ionic conductivity is improved when thin films are nanostructured.
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Anti‐inflammatory and anti‐chemotactic effects of dietary flaxseed oil on CD8+ T cell/adipocyte‐mediated cross‐talk
Authors: Monk Jennifer M. , Liddle Danyelle M. , Brown Morgan J. , Zarepoor Leila , De Boer Anna A. , Ma David W. L. , Power Krista A. , Robinson Lindsay E. 
Published: November 2015

ScopeCD8+ T cell/adipocyte paracrine interactions represent a critical step in the development of the obese inflammatory phenotype that is disrupted by long‐chain n‐3 PUFA. Our objective was to determine the effect of flaxseed‐derived n‐3 PUFA (α‐linolenic acid) on these paracrine interactions.Methods and resultsC57BL/6 mice were fed 3.5% flaxseed oil (FX) + 3.5% corn oil diet w/w or an isocaloric 7% corn oil w/w control diet (CON) for 3 wk. 3T3‐L1 adipocytes and purified primary splenic CD8+ T cells were cocultured at an obese cellular ratio (10% CD8+ T cells) and LPS‐stimulated (10 ng/mL mimicking obese circulating endotoxin levels) for 24 h. FX cocultures reduced (i) secreted IL‐6, tumor necrosis factor α (TNF‐α), macrophage chemoattractant protein 1 (MCP‐1), macrophage inflammatory protein 1α (MIP‐1α), and RANTES (regulated on activation, normal T cell expressed and secreted) levels; (ii) activation of inflammatory transcription factors NFκB (nuclear factor kappa‐light‐chain‐enhancer of activated B cell) p65 and signal transducer and activator of transcription‐3 (STAT3); and (iii) RAW264.7 macrophage chemotaxis versus CON (p ≤ 0.05). Coculture of pre‐inflamed adipocytes (10 ng/mL LPS, 24 h prior to CD8+ T‐cell addition) resulted in reduced secretion of IL‐6, IL‐1β, MCP‐1, MCP‐3, MIP‐1β, and RANTES in FX cocultures versus CON (p ≤ 0.05).ConclusionFX exerts an anti‐chemotactic and anti‐inflammatory effect on CD8+ T cell/adipocyte paracrine interactions (cross‐talk), which has the potential to mitigate macrophage chemotaxis which drives components of the obese phenotype.
Intrauterine fetal demise after prenatal diagnosis of congenital heart disease: assessment of risk
Authors: Divanovic Allison , Bowers Katharine , Michelfelder Erik , Jaekle Ronald , Newman Tondra , Marcotte Michael , Habli Mounira , Cnota James F. 
Published: November 2015

AbstractObjectivesElective deliveries in fetal congenital heart disease (CHD) attempt to balance fetal and neonatal risk with the goal of optimizing overall outcome. However, the magnitude of the risk for intrauterine fetal demise (IUFD) is unclear. This study aimed to (1) determine the rate of IUFD and (2) identify fetal risk factors associated with IUFD.MethodsRetrospective review of pregnancies complicated by CHD between 1998 and 2010. Data were collected regarding pregnancy outcome, extracardiac anomalies (ECA), genetic and cardiac diagnoses, severity of valve regurgitation, gestational age at birth and birth weight. Fisher's exact test and odds ratios were used to compare outcomes between groups.ResultsA total of 501 pregnancies analyzed resulted in 445 live births, 22 IUFD, 16 terminations and 18 unknown outcomes. Amongst IUFD, 27% had a genetic diagnosis, 50% had an ECA and 27% had severe valve regurgitation. IUFD odds increased threefold with ECA and sevenfold with severe valve regurgitation. IUFD occurred in 1.2% without risk factors.ConclusionsIUFD in fetuses with CHD is associated with ECA, genetic syndromes and severe valve regurgitation. In absence of these fetal characteristics, the occurrence of IUFD is low, although it remains higher than in fetuses without CHD. © 2015 John Wiley & Sons, Ltd.
Half‐Heusler materials as model systems for phase‐separated thermoelectrics
Authors: Fecher Gerhard H. , Rausch Elisabeth , Balke Benjamin , Weidenkaff Anke , Felser Claudia 
Published: November 2015

AbstractSemiconducting half‐Heusler compounds based on NiSn and CoSb have attracted attention because of their good performance as thermoelectric materials. Nanostructuring of the materials was experimentally established through phase separation inalloys when mixing different transition metals (T,,) or main group elements (M,). The electric transport properties of such alloys depend not only on their micro‐ or nanostructure but also on the atomic‐scale electronic structure. In the present work, the influence of the band structure and density of states on the electronic transport and thermoelectric properties is investigated in detail for the constituents of phase‐separated half‐Heusler alloys. The electronic structure is calculated using different theoretical schemes for ordered and disordered materials. It is found that chemical disorder scattering influences the electronic transport properties in all substituted materials. Substitution in NiSn‐based compounds leads to high performance n‐type materials but only moderate p‐type thermoelectric properties. The latter is caused by the influence of the valence band on the conductivity. For CoSb‐based compounds, it is found that Sb substitution with Sn keeps the bands close to the Fermi energy intact. The resulting substituted alloys are excellent p‐type materials because of the characteristic valence band structure in thedirection.The figure shows thefcccrystal structure () of the half‐Heusler compounds (prototype: MgAgAs,,, 216).
Parameters of a Cloud‐Like Distribution of Electrons in the Ionosphere
Authors: Hughes Leroy R. 
Published: November 2015

Wide bandwidth differential phase measurements have been taken on the 162 and 324 Mc/s emissions of Anna lB and 63038c satellites from Point Buchan, Calif. and College, Alaska. The measurements are analyzed to determine parameters describing fine scale electron distribution in contrast to smooth ionosphere parameters.Electron content variations show a cloud‐like structure with apparent scale sizes less than 20 m in both day and night ionospheres.
Design of a Satellite‐to‐Satellite Communications Experiment To Explore HF/VHF Guided Propagation in the Lower Ionosphere
Authors: Barker James I. , Grossi Mario D. 
Published: November 2015

The design of an experiment to provide conclusive proof of the existence of HF/VHF whispering gallery propagation in the ionosphere below F2Hmax (and to explore its characteristics) has recently been completed and the necessary instrumentation developed and built.The design has been performed on the basis of the results of the simulation of the phenomenon in a digital computer which has integrated in a self‐consistent model the fragmentary, incomplete knowledge of the phenomenon available to date.A satellite‐to‐satellite configuration has be~n chosen, as suitable both to prove unambiguously the existence of whispering‐gallery propagation in the lower ionosphere, and for gathering information basic to the evaluation of the practical usefulnes~ of the guided paths for communications, and to their channel characterization.