bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nephrotic syndrome in a child with neurofibromatosis type 1: A case report and literature review
Authors: Cheng Bingjie , Yang Huihui , Huang Lin , Liao Panli , Peng Fei , Wang Xiaowen 
Published: September 2024

AbstractNeurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that caused by NF1 mutations. NF1 gene encodes neurofibromin (a GTPase‐activating protein) and plays a regulatory role in many signalling pathway such as the Ras/MAPK pathway, which is important for regulating cell growth, proliferation and neural development. Therefore, NF1 gene mutations causes the excessive activation of signalling pathways and uncontrolled cell growth. NF1 exhibits complete genetic penetrance and clinical heterogeneity. Glomerular disease has rarely been reported in patients with NF1, especially in children. Currently, the relationship between NF1 and nephrotic syndrome is unclear. Here, we present a case of NF1 with nephrotic syndrome and further explore the association between NF1 and glomerular diseases. It also reminds clinicians that NF1 has complex and highly variable clinical manifestations and that a comprehensive workup is essential for patients.
Lipids and adipocytes involvement in tumor progression with a focus on obesity and diet
Authors: Calabrese Chiara , Miserocchi Giacomo , De Vita Alessandro , Spadazzi Chiara , Cocchi Claudia , Vanni Silvia , Gabellone Sofia , Martinelli Giovanni , Ranallo Nicoletta , Bongiovanni Alberto , Liverani Chiara 
Published: September 2024

SummaryThe adipose tissue is a complex organ that can play endocrine, metabolic, and immune regulatory roles in cancer. In particular, adipocytes provide metabolic substrates for cancer cell proliferation and produce signaling molecules that can stimulate cell adhesion, migration, invasion, angiogenesis, and inflammation. Cancer cells, in turn, can reprogram adipocytes towards a more inflammatory state, resulting in a vicious cycle that fuels tumor growth and evolution. These mechanisms are enhanced in obesity, which is associated with the risk of developing certain tumors. Diet, an exogenous source of lipids with pro‐ or anti‐inflammatory functions, has also been connected to cancer risk. This review analyzes how adipocytes and lipids are involved in tumor development and progression, focusing on the relationship between obesity and cancer. In addition, we discuss how diets with varying lipid intakes can affect the disease outcomes. Finally, we introduce novel metabolism‐targeted treatments and adipocyte‐based therapies in oncology.
Balancing policy objectives: Cambodia's COVID‐19 emergency cash assistance scheme for workers
Authors: Im Soksamphoas , Ford Michele 
Published: September 2024

AbstractWelfare programs in emerging economies are, in most cases, highly selective. This article illustrates this point by exploring Cambodia's emergency cash assistance scheme coverage for workers affected by the COVID‐19 pandemic. Drawing on policy analysis and interviews with government officials, industry representatives, and garment and tourism unions, it analyzes the level of benefit and efficacy of the initiative for different groups of workers. Based on this analysis, we find that garment factory and tourism workers received better support than workers in other sectors as a consequence of industry lobbying and strategic decision‐making on the part of the government designed to mitigate the impact of the pandemic on those sectors. Our analysis also reveals, however, that the relatively informal nature of even formal‐sector workplaces in Cambodia meant that the scheme's impact was highly varied even among these targeted groups of workers. We conclude with a discussion of the findings' broader implications.Related ArticlesAsongu, Simplice, and Nicholas M. Odhiambo. 2023. “The Effect of Inequality on Poverty and Severity of Poverty in Sub‐Saharan Africa: The Role of Financial Development Institutions.” Politics & Policy 51(5): 898–918. https://doi.org/10.1111/polp.12558.Lachapelle, Erick, Thomas Bergeron, Richard Nadeau, Jean‐François Daoust, Ruth Dassonneville, and Éric Bélanger. 2021. “Citizens' Willingness to Support New Taxes for COVID‐19 Measures and the Role of Trust.” Politics & Policy 49(3): 534–65. https://doi.org/10.1111/polp.12404.Onyango, Gedion, and Japheth Otieno Ondiek. 2022. “Open Innovation during the COVID‐19 Pandemic Policy Responses in South Africa and Kenya.” Politics & Policy 50(5): 1008–31. https://doi.org/10.1111/polp.12490.
Visual Analysis and the Contentious Politics of the Radical Right
Authors: Caiani Manuela 
Published: September 2024

ABSTRACTAlthough images are very important for political actors and social movements, including the radical right (RR), empirical studies still rarely integrate visual material as relevant data for understanding radical right politics. This article outlines this new and growing field of research (i.e., visuality and the RR), critically reviewing existing studies from the perspective of both visual studies of social movements and contentious politics, which are rarely applied to the RR, and the methodology of working with images, offering empirical case studies (European and beyond) to illustrate the argument. The findings reveal the main functions of the use of visuals for the radical right, as well as the benefits (but also the challenges) of studying radical right politics through the lens of visual analysis. A conceptual framework is proposed to capture this dominant visual politics of the radical right. As shown, two dimensions emerge as the most theoretically relevant for the radical right: The discursive meaning of images (the story itself, telling the story, eliciting the story) and the communicative function of images (visual expression by the movement or others, visibility), which combine agency and addressee.
Critical Challenges to the Sociology of Work: From a Perspective of Russian Labor Studies
Authors: Popov Andrei , Baimurzina Guzel 
Published: September 2024

ABSTRACTGlobal changes currently roiling the contemporary world of work present a significant challenge for the sociology of work. The lifestyles of many people are becoming more dynamic and uncertain. As work itself starts to lose its familiar outlines, the employment paradigm that formed during the industrial period seems increasingly inapplicable. Such transformations give rise to criticism of existing concepts and the emergence of new discourses that simultaneously expand and complicate an understanding of the prospects for further development. In this article, we attempt to uncover problems that limit the possibility of generalizing scientific understanding in the field of sociology of work. Particular attention is paid to the integration of Russian experience into the global agenda. The review highlights the importance of clarifying the blurred conceptual framework of the sociology of work, enhancing the distinction between work and life, and identifying the possibilities and limitations of using big data for empirical analysis. In conclusion, we emphasize the need to counter the fragmentation of the sociology of work and its “dissolution” into other areas of knowledge by providing a strong theoretical background while maintaining the comparability of measurements. Addressing these gaps is essential for a more accurate reflection of modern labor relations.
REACH: Research as regeneration
Authors: Deger Jennifer , Coffey Victoria Baskin 
Published: September 2024

AbstractThe galvanising aim in curating ‘Epistemic attunements’ has been to reach beyond the infrastructural imaginaries of the corporate publishing regimes that so brutally standardise the form, production, and distribution of research. Yet rather than being wholly enamoured with the pursuit of new publics, or with the kind of reach and influence that our bespoke digital platform affords, we take the idea of ‘reach’ in a different direction. In short, what we propose here is that reaching beyond anthropology offers a way to return the discipline to its core commitments. REACH explores what happens when anthropology and its interlocutors come together to cultivate shared grounds of epistemic care and concerns. It asks, what happens when multiple histories show up in the process? It proposes that therein lies the grounds for a regenerative anthropology.
Luŋ'thun: Sand, saltwater, and collaborative attunements
Authors: Gurrumuruwuy Paul , Deger Jennifer , Guruŋulmiwuy Enid , Coffey Victoria Baskin , Balanydjarrk Meredith , Balpatji Warren 
Published: September 2024

AbstractThis audio‐visual essay works with the epistemic imperatives of our research subject—the sands and saltwater of a small stretch of coastline in northern Australia. Orchestrating a series of sounds and images together with a gentle rhythm of text‐based Yolŋu (human/Indigenous) elaboration, we seek to enable others to attune to a material dynamics of collaboration and co‐creation made manifestly palpable in the kinetic zones of coastal life. Rather than either simply telling, or showing, we invite our ‘readers’ to enter into a slow process of attuning to the forms of sensuous instruction offered directly from the wäŋa (land, environment, Country). In this way we orientate towards research as a shared and emergent processes of becoming knowledgeable with more‐than‐human worlds. The result is a Yolŋu‐led digital experiment in sovereign knowledge production: a modelling of a site‐specific, participatory onto‐epistemics intended to inspire others towards the possibilities of creative, relational modes of more‐than‐human research.
Filming jilba: Sensing beyond the exclusionary fictions of climate science
Authors: Williams Citt , Kulka Jarramali 
Published: September 2024

Abstract‘Filming jilba’ makes up part of a larger practice‐based research project focusing on the body as a site of climate sensitivity and perception. Investigated in collaboration with Bama colleague, Jarramali Kulka (a Kuku Yalanji‐Nyungkal man from Australia's tropical Far North Queensland), and his custodial practice jilba (pronounced jil‐ba), the article describes the embryotic growth of a performative practice‐based methodology that leads with intimate sensing—a generative counter position to remote sensing—and grows it phenomenologically through the field work of a documentary media practice. In attempting to speak across epistemic divides, the project process addresses the exclusionary fictions that conventional climate sensing performs by attuning to ‘a world that already has its own stories’.
Short day promotes gall swelling by a CONSTANS‐FLOWERING LOCUS T pathway in Zizania latifolia
Authors: Zhang Zhiping , Shi Wangjie , Gu Jiawen , Song Sixiao , Xiao Meng , Yao Junchi , Liu Yancheng , Jiang Jiezeng , Miao Minmin 
Published: September 2024

SUMMARY“Jiaobai” is a symbiont of Zizania latifolia and Ustilago esculenta, producing fleshy galls as a popular vegetable in South and East Asia. Current “Jiaobai” cultivars exhibit abundant variation in their gall formation date; however, the underlying mechanism is not clear. In this study, a strict short‐day (SD) “Jiaobai” line “YD‐3” was used. Plants were treated with two day‐length regimes [14 h/10 h (day/night) (control) and 8 h/16 h (day/night) (SD)] from 100 to 130 days after planting. The gall swelling rate of the two treatments and another early SD treatment (from 60 to 90 days after planting), together with the contingent flowering plants in the experiment population, revealed that SD can improve both gall enlargement and flowering of “Jiaobai” plants. Comparison of RNA sequencing data among control, SD swelling, and SD flowering treatments of leaves and meristems indicated that SD promotion of “Jiaobai” swelling is conducted by the CONSTANS (CO)‐FLOWERING LOCUS T (FT) pathway, similar but not identical to the SD‐induced flowering pathway in Z latifolia and rice. “Virus‐induced gene silencing”, “Yeast one‐hybrid assay” and “Dual‐luciferase assay” showed that a FT gene, ZlGsd1, is critical in SD promotion of gall formation and is positively regulated by a CO gene, ZlCOL1. Our study elucidated how photoperiod affects the formation of a unique organ produced by plant‐fungus symbiosis. The difference in SD response between “Jiaobai” and rice, as well as their potential applications in breeding of “Jiaobai” and rice, were also discussed.
ТОКСИЧЕСКИЕ ЭФФЕКТЫ ВОЗДЕЙСТВИЯ ХРИЗОТИЛ АСБЕСТА
Authors: Кусаинова А.А. , Айнагулова Г.С. , Арипова А.А. 
Published: September 2024

Болезни легких, связанные с воздействием асбеста, остаются важной проблемой для медицины. Асбестоз — это хроническое заболевание легкого, при котором легочная ткань постепенно заменяется фиброзной тканью в результате воздействия асбестовых волокон. Хризотил, считается наименее токсичной формой асбестового волокна, за счет его извилистой формы. При вдыхании такие волокна преимущественно оседают в верхних дыхательных путях.
Известны различные механизмы клеточного ответа на действие асбеста. Проникновение асбестовых волокон в клетки приводит к увеличению АФК и вызывает окислительный стресс, что приводит к повреждению клеточных компонентов и ДНК. В результате, возможна активация различных сигнальных систем, которые запустят клеточную гибель или фиброз и дальнейший канцерогенез.
Результаты нашего исследования, проведенного на клеточной линии фибробластов легкого MRC5, показали, что асбест оказывает генотоксическое и цитотоксическое действие. Окислительный клеточный стресс, вызванный действием следующих доз хризотила 2,5, 5 и 10 мг/см2, имеет дозозависимый эффект. Чем выше концентрация асбеста и дольше экспозиция, тем выше уровень АФК в клетках. Максимальная концентрация клеточных АФК наблюдалась через 24 часа воздействия разными дозами асбеста.При этом кометный анализ показал, что процент хвостовой ДНК увеличивался в зависимости от увеличения дозы хризотила, что позволяет сделать вывод о том, что асбест приводит к образованию двунитевых разрывов ДНК.
Цитотоксичность асбеста возрастала с увеличением концентрации и времени воздействия. Значительный дозозависимый эффект асбеста наблюдался через 48 часов, когда процент жизнеспособных клеток составил 83%, 74 и 65,9% при действии соответствующих доз асбестовых волокон.Помимо оценки жизнеспособности клеток, мы исследовали количество копий внеклеточной митохондриальной ДНК. Как показали наши данные, количеств внеклеточной мтДНК увеличивается с продолжительностью времени экспозиции хризотилом. Максимальное количество копий было обнаружено через 48 часов воздействия всех выбранных концентраций асбестовых волокон. В целом наблюдается связь между уровнем жизнеспособности клеток и количеством копий внеклеточной мтДНК, однако корреляции между этит параметрами найдено не было.
Изучение острого ответа на действие хризотила проводилось также на животной модели. Крысам линии Вистар вводили дозы 25 мг и 50 мг асбеста. По морфометрическим показателям ультраструктуры митохондрий крыс более серьезные изменения были выявлены в митохондриях крыс, при влиянии асбеста в дозе 50 мг, которые характеризовались достоверным увеличением площади, периметра и среднего диаметра внешней и внутренней мембран и диаметра крист. Так же был проведен анализ содержания паркина (PRKN) и митофилина в ткани легких крыс под действием хризотил асбеста. Было обнаружено значительное снижение уровня PRKN, контролирующего митофагию митохондрий.
A Review of the Applications of Machine Learning for Prediction and Analysis of Mechanical Properties and Microstructures in Additive Manufacturing
Authors: Deshmankar Atharv P. , Challa Jagat Sesh , Singh Amit R. , Regalla Srinivasa Prakash 
Published: September 2024

Abstract
This article provides an insightful review of the recent applications of machine learning (ML) techniques in additive manufacturing (AM) for the prediction and amelioration of mechanical properties, as well as the analysis and prediction of microstructures. AM is the modern digital manufacturing technique adopted in various industrial sectors because of its salient features, such as the fabrication of geometrically complex and customized parts, the fabrication of parts with unique properties and microstructures, and the fabrication of hard-to-manufacture materials. The functioning of the AM processes is complicated. Several factors such as process parameters, defects, cooling rates, thermal histories, and machine stability have a prominent impact on AM products’ properties and microstructure. It is difficult to establish the relationship between these AM factors and the AM end product properties and microstructure. Several studies have utilized different ML techniques to optimize AM processes and predict mechanical properties and microstructure. This article discusses the applications of various ML techniques in AM to predict mechanical properties and optimization of AM processes for the amelioration of mechanical properties of end parts. Also, ML applications for segmentation, prediction, and analysis of AM-fabricated material’s microstructures and acceleration of microstructure prediction procedures are discussed in this article.
Flower Pollination Algorithm With Ring Topology for Multisolution Spaces to Solve the Disassembly Line Balancing Problem
Authors: Zhang Lei , Jin Rui , Geng Xiaorong , Hu Jiaqi , Bao Hong 
Published: September 2024

Abstract
The disassembly line balancing problem (DLBP) is of significant importance in the product recycling process. However, existing DLBP research has primarily proposed improved optimization algorithms for single-solution space. To provide decision makers with more efficient disassembly solutions, this article chooses three classical layouts (straight, U-shaped, and parallel) to broaden the solution space and expands an incomplete DLBP with multisolution spaces (DLBP-MS). By employing the strategy of incomplete disassembly, only the essential components are retained. In DLBP-MS, the disassembly information from used products is processed and imported into the three types of disassembly spaces to be solved and compared to find suitable disassembly solutions. And a multiobjective mathematical model is developed, and this includes factors such as workstation count, free time, disassembly smoothness index, carbon emission, and disassembly revenue. The part constraints are established based on directed graphs, and the encoding and decoding methods for multisolution spaces disassembly sequences in the random incomplete case are designed, respectively. A ring topology-based flower pollination algorithm (RTFPA) is introduced to effectively address the DLBP-MS. The solution set obtained during the iterative process is divided into subsets based on the congestion level and the overall diversity is preserved by internal optimization of these subsets. After that, the RTFPA is applied to the DLBP-MS of waste cell phones and computers. The improvement of the algorithm's optimization ability under different solution spaces is verified by comparing the results with those obtained from four other algorithms.
Design, Simulation, and Fabrication of Composite Lattice Orthoses With Enhanced Structural Performance
Authors: Mo Yaru , Johnson Shane 
Published: September 2024

Abstract
Orthoses play a critical role in rehabilitation by providing fracture stabilization, external load protection, and deformity correction. Traditional methods of orthotic manufacturing often result in increased bulkiness and weight due to material and processing limitations, and reduced breathability leading to potential skin problems. This study aims to enhance structural performance of orthoses through the utilization of a fiber-reinforced composite lattice design fabricated using a coreless filament winding process. An arm brace was designed and manufactured, which incorporates four modules made of fiberglass/polystyrene composite lattices assembled together using adjustable thermoplastic connectors. To simulate the structural performance, a finite element model (FEM) was constructed with careful consideration of the interactions between the connectors and the lattice modules, and this was subsequently validated through experiment. In comparison to a benchmark brace made of polylactic acid lattice, the composite brace exhibits a significant reduction in thickness (59%) and weight (38%) while maintaining similar structural performance. The validation test indicates the FEM’s reliability in predicting structural stiffness and strength of the composite brace, with the predicted load-bearing capacity being slightly conservative (5%) compared to experimental results. Composite lattice structures represent a significant advancement in the design of lightweight, high strength, and breathable orthoses. Moreover, the developed FEM serves as a valuable tool for accurately predicting structural performance and optimizing orthotic design under varying loading conditions.
Amplifying Student Viewpoints on Inclusive Student Experiences for Inclusive Excellence in Kinesiology
Authors: Brooks DeAnne Davis , Duley Helen Yolisa , Pipe Laura M. , Fullwood Carla C. , Aiken Christopher A. 
Published: September 2024

The purpose of this paper is to share how the American Kinesiology Association’s Diversity, Equity and Inclusion Committee envisioned, planned, and created an opportunity to show how inclusive excellence can be implemented as a strategy for transformation and change. This was achieved by listening to and intentionally responding with positive outcomes to students who voice their lived experiences in an institution of higher education. The Viewpoints on Inclusive Student Experiences (VOISES) model of student/faculty engagement is explained, along with reflections from two faculty members who participated in VOISES panels—one as an audience member and the other as a panel moderator. The discussion includes suggestions for incorporating student voices generally and the VOISES model specifically as part of a comprehensive diversity, equity, and inclusion strategy.
Modulation of
Vibrio cholerae
gene expression through conjugative delivery of engineered regulatory small RNAs
Authors: Menendez-Gil Pilar , Veleva Diana , Virgo Mollie , Zhang Jige , Ramalhete Rita , Ho Brian T. 
Published: September 2024

ABSTRACT

The increase in antibiotic resistance in bacteria has prompted the efforts in developing new alternative strategies for pathogenic bacteria. We explored the feasibility of targeting
Vibrio cholerae
by neutralizing bacterial cellular processes rather than outright killing the pathogen. We investigated the efficacy of delivering engineered regulatory small RNAs (sRNAs) to modulate gene expression through DNA conjugation. As a proof of concept, we engineered several sRNAs targeting the type VI secretion system (T6SS), several of which were able to successfully knockdown the T6SS activity at different degrees. Using the same strategy, we modulated exopolysaccharide production and motility. Lastly, we delivered an sRNA targeting T6SS into
V. cholerae
via conjugation and observed a rapid knockdown of the T6SS activity. Coupling conjugation with engineered sRNAs represents a novel way of modulating gene expression in
V. cholerae
opening the door for the development of novel prophylactic and therapeutic applications.

IMPORTANCE

Given the prevalence of antibiotic resistance, there is an increasing need to develop alternative approaches to managing pathogenic bacteria. In this work, we explore the feasibility of modulating the expression of various cellular systems in
Vibrio cholerae
using engineered regulatory sRNAs delivered into cells via DNA conjugation. These sRNAs are based on regulatory sRNAs found in
V. cholerae
and exploit its native regulatory machinery. By delivering these sRNAs conjugatively along with a real-time marker for DNA transfer, we found that complete knockdown of a targeted cellular system could be achieved within one cell division cycle after sRNA gene delivery. These results indicate that conjugative delivery of engineered regulatory sRNAs is a rapid and robust way of precisely targeting
V. cholerae
.