bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near Real‐Time Earthquake Monitoring in Texas Using the Highly Precise Deep Learning Phase Picker
Authors: Chen Yangkang , Savvaidis Alexandros , Siervo Daniel , Huang Dino , Saad Omar M. 
Published: October 2024

AbstractArtificial intelligence (AI) seismology has witnessed enormous success in a variety of fields, especially in earthquake detection and P and S‐wave arrival picking. It has become widely accepted that DL techniques greatly help routine seismic monitoring by enabling more accurate picking than traditional pickers like STA/LTA. However, a completely automatic AI‐driven earthquake monitoring framework has not been reported due to the concerns of potential false positives using DL pickers. Here, we propose a novel AI‐facilitated near real‐time monitoring framework using a recently developed deep learning (DL) picker (EQCCT) that has been deployed in the Texas seismological network (TexNet). For the West Texas area, TexNet's seismic monitoring relies on the EQCCT picker to report earthquake events. For earthquakes with a magnitude above two, the picks are further validated by analysts to output the final TexNet catalog. Due to the fast‐increasing seismicity caused by continuing oil&gas production in West Texas, this AI‐facilitated framework significantly relieves the workload of TexNet analysts. We show the mean absolute error (MAE) of automatic magnitude estimation for the magnitude‐above‐two earthquakes is smaller than 0.15 in West Texas and MAEs of hypocenter locations within 2.6 km in both distance and depth estimates. This research provides more evidence that DL pickers can play a fundamental role in daily earthquake monitoring.
Persistent Summer North Atlantic Jet Variability: Dynamical Feedbacks and Model‐Observation Discrepancies
Authors: Ossó Albert , Ennemoser Florian 
Published: October 2024

AbstractPersistent fluctuations in the latitudinal position of the North Atlantic (NATL) jet stream are closely linked to extreme weather anomalies, particularly over Europe. Accurately representing jet stream persistence in climate models is essential for enhancing the reliability of future regional extreme weather projections. This study investigates the summer persistence of the NATL jet stream latitudinal fluctuations and the Summer North Atlantic Oscillation (SNAO) using data from CMIP6 models and ERA5 reanalysis. Our findings reveal that CMIP6 models generally overestimate persistence compared to ERA5 during the historical period. Utilizing the relative vorticity tendency equation, we assess the strength of the eddy‐mean flow feedback and identify a positive relationship between persistence and feedback strength across models. We also found that a large fraction of the intermodel spread in precipitation persistence is associated with differences in the persistence of jet fluctuations.
Madden Julian Oscillation Moves Faster as the Meridional Moisture Gradient Intensifies in a Warming World
Authors: Dasgupta Panini , Roxy M. K. , Nam SungHyun , Prajeesh A. G. , Saranya J. S. , Zhang Chidong , Ling Jian , Kim Daehyun 
Published: October 2024

AbstractThe eastward‐moving large‐scale convective system associated with the Madden‐Julian Oscillation (MJO) significantly impact global weather and climate. Recent decades have seen notable changes in the MJO's lifecycle due to non‐uniform tropical ocean warming, with the roles of natural climate variability and anthropogenic influence still requiring quantification. This study examines observed and projected long‐term changes in the MJO phase speed using four twentieth‐century reanalyses and CMIP6 simulations. We find a substantial increase in MJO phase speed in three reanalyses during the twentieth century (0.6–1.2 m s⁻1 century⁻1) and further increase in MJO phase speed during the twenty‐first century (0.3–1.5 m s⁻1 century⁻1), with notable multidecadal fluctuations. We attribute the overall acceleration of the MJO to the global warming‐driven increase in the meridional moisture gradient around the warm pool while attributing the multidecadal variability in the MJO phase speed to changes in the zonal moisture gradient associated with the Pacific Decadal Oscillation.
Plant and Microbial Carbon Are Important Drivers of Free‐Living Nitrogen Fixation in Tropical Forest Soils: A New Discovery of Carbon‐Driven Nitrogen Input
Authors: Xu Meichen , Fan Linjie , Li Andi , Liu Qiyan , Yu Guangcan , Wang Senhao , Zhang Baixin , Ye Qing , Mo Jiangming , Zheng Mianhai 
Published: October 2024

AbstractNitrogen (N) availability limits plant growth and soil carbon (C) sequestration in N‐limited ecosystems, however, plant and soil C feedback on the free‐living nitrogen fixation (FLNF) process is poorly understood. Moreover, whether this feedback is influenced by initial N availability in leguminous and non‐leguminous forest soils has not been clarified. Here, we found that the addition of plant‐ and microbial‐derived C significantly enhanced soil nitrogenase activity (13∼28%) and that microbial‐derived C had a more positive impact. These positive effects were attributed to the direct C‐energy supply (0.49∼0.84) rather than variations in soil microbial activity (−0.01∼0.21) and substrate resources (−0.45∼0.27). Long‐term N addition did not inhibit FLNF. C addition promoted FLNF in soils of the two forests, but the response rate was higher in the leguminous forest soils. Our study reveals that increased soil C availability can drive FLNF in tropical forests, enhancing our understanding of the soil C‐N coupling mechanism.
Process‐Based Modeling of Ecosystem‐Level Monoterpene From a Japanese Larch (Larix kaempferi) Forest
Authors: Chen Zhanzhuo , Kato Tomomichi , Ito Akihiko , Miyauchi Tatsuya , Takahashi Yoshiyuki , Tang Jing 
Published: October 2024

AbstractGlobally, the emission of biogenic volatile organic compounds (BVOC) by plants represents the dominant source of volatile organic compounds emitted to the atmosphere. Monoterpenes, as the major BVOC group, can contribute to forming secondary organic aerosols and influence cloud properties. In this study, we developed a process‐based monoterpene module in the Vegetation Integrative SImulator for Trace gases (VISIT) model by considering the production, storage, and emission of monoterpene as three main processes. We further evaluated the modeled monoterpene emissions against the ecosystem‐level observation data at a half‐hour scale at a Japanese larch (Larix kaempferi) forest site on Mt. Fuji, Japan. The VISIT model performed with relatively higher accuracy with a Willmott's index of agreement at 0.61, a mean bias error (MBE) at 0.29, and a root mean squared error (RMSE) at 0.43, comparable to that of Model of Emissions of Gases and Aerosols from Nature model with a Willmott's index of agreement at 0.63, a MBE at 0.40, and a RMSE at 0.54. In a long‐term simulation under high CO2 emission scenarios, the ratio between monoterpene emission and gross primary production exhibited a stronger correlation with CO2 concentration than temperature. Our study provides a process‐based modeling approach for more accurately simulating monoterpene emissions from Japanese larch.
A Reappraisal of Nappe Structures and Strain Patterns in the Core of the Variscan Orogen (French Massif Central)
Authors: Vanardois Jonas , Trap Pierre , Teyssier Christian , Whitney Donna L. 
Published: October 2024

AbstractMajor influences on the architecture of orogens include the overall thermal conditions of orogeny (hot vs. cold) and the angle of collision (orthogonal vs. oblique). In the French Massif Central of the Variscan orogen, a cold‐orogen style crustal nappe architecture was interpreted in the Haut‐Allier, located in the core of the orogen. Based on this model, the Variscan orogenic crust is described as the superposition of three main allochthonous tectonic units juxtaposed along major thrust faults. However, based on a detailed structural analysis, we have found instead that the region is dominated by a network of anastomosing conjugate and coeval dextral and sinistral shear zones striking WNW‐ESE and ENE‐WSW, respectively. The dextral WNW‐trending shear zones are predominant, whereas the sinistral NE shear zones are mainly located in the eastern part of the massif. Between these sub‐vertical shear zones, a sub‐horizontal foliation is observed. Our results indicate that all planar fabrics were partially synchronous during suprasolidus low‐pressure‐high‐temperature conditions. Strain partitioning occurred from high‐temperature suprasolidus conditions to subsolidus retrogression and may represent orogen‐parallel flow, suggesting hot‐orogen style. These results call into question the validity of the crustal nappe model in the Haut‐Allier. Based on new structural data and related observations, we propose a new model in which metamorphic gaps between tectonic units are explained by the juxtaposition of different structural domains by displacement along strike‐slip shear zones.
Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice
Authors: Kovarova Veronika , Bordes Joeri , Mitra Shiladitya , Narayan Sowmya , Springer Margherita , Brix Lea Maria , Deussing Jan M. , Schmidt Mathias V. 
Published: October 2024

Abstract
The co-chaperone FKBP51, encoded by FKBP5 gene, is recognized as a psychiatric risk factor for anxiety and depressive disorders due to its crucial role in the stress response. Another key modulator in stress response regulation is the corticotropin releasing hormone (CRH), which is co-expressed with FKBP51 in many stress-relevant brain-regions and cell-types. Together, they intricately influence the balance of the hypothalamic-pituitary-adrenal (HPA) axis, one of the primary stress response systems. Previous research underscores the potential moderating effects these genes have on the regulation of the stressful life events towards the vulnerability of major depressive disorder (MDD). However, the specific function of FKBP51 in CRH-expressing neurons remains largely unexplored. Here, through deep behavioral phenotyping, we reveal heightened stress effects in mice lacking FKBP51 in CRH co-expressing neurons (CRH

FKBP5−/−
), particularly evident in social contexts. Our findings highlight the importance of considering cell-type specificity and context in comprehending stress responses and advocate for the utilization of machine-learning-driven phenotyping of mouse models. By elucidating these intricacies, we lay down the groundwork for personalized interventions aimed at enhancing stress resilience and individual well-being.
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout
Authors: Chi Jingwei , Chen Ying , Li Changgui , Liu Shiguo , Che Kui , Kong Zili , Guo Ziheng , Chu Yanchen , Huang Yajing , Yang Libo , Sun Cunwei , Wang Yunyang , Lv Wenshan , Zhang Qing , Guo Hui , Zhao Han , Yang Zhitao , Xu Lili , Wang Ping , Dong Bingzi , Hu Jianxia , Liu Shihai , Wang Fei , Zhao Yanyun , Qi Mengmeng , Xin Yu , Nan Huiqi , Zhao Xiangzhong , Zhang Wei , Xiao Min , Si Ke , Wang Yangang , Cao Yihai 
Published: October 2024

AbstractDefective renal excretion and increased production of uric acid engender hyperuricemia that predisposes to gout. However, molecular mechanisms underlying defective uric acid excretion remain largely unknown. Here, we report a rare genetic variant of gout-unprecedented NUMB gene within a hereditary human gout family, which was identified by an unbiased genome-wide sequencing approach. This dysfunctional missense variant within the conserved region of the NUMB gene (NUMBR630H) underwent intracellular redistribution and degradation through an autophagy-dependent mechanism. Mechanistically, we identified the uric acid transporter, ATP Binding Cassette Subfamily G Member 2 (ABCG2), as a novel NUMB-binding protein through its intracellular YxNxxF motif. In polarized renal tubular epithelial cells (RTECs), NUMB promoted ABCG2 trafficking towards the apical plasma membrane. Genetic loss-of-function of NUMB resulted in redistribution of ABCG2 in the basolateral domain and ultimately defective excretion of uric acid. To recapitulate the clinical situation in human gout patients, we generated a NUMBR630H knock-in mouse strain, which showed marked increases of serum urate and decreased uric acid excretion. The NUMBR630H knock-in mice exhibited clinically relevant hyperuricemia. In summary, we have uncovered a novel NUMB-mediated mechanism of uric acid excretion and a functional missense variant of NUMB in humans, which causes hyperuricemia and gout.
Uncovering pathway and mechanism of simultaneous thiocyanate detoxicity and nitrate removal through anammox and denitrification
Authors: Chen Xue , Duan Fuang , Yu Xi , Xie Yuyang , Wang Zhibin , Ni Shou-Qing 
Published: October 2024

AbstractThiocyanate (SCN−) exists in various industries and is detrimental to the ecosystem, necessitating cost-effective and environmentally benign treatment. In response to alleviate the bacterial toxicity of SCN−, this study developed a two-stage coupled system by tandem of anammox in reactor 1 (R1) and SCN−-driven autotrophic denitrification in reactor 2 (R2), achieving simultaneous removal of SCN− and nitrogen. The total nitrogen removal efficiency of the coupled system was 92.42 ± 1.98%, with nearly 100% of SCN− elimination. Thiobacillus was responsible for SCN− degradation. The deduced degradation pathway of SCN− was via the cyanate pathway before coupling, followed by the co-action of cyanate pathway and carbonyl sulfide pathway after coupling. Although scaling-up study is needed to validate its applicability in real-world applications, this study contributes to the advancement of sustainable and cost-effective wastewater treatment technologies, being an attractive path for low-carbon nitrogen removal and greenhouse gas emission-free technology.
Alginate-modified graphene oxide anchored with lactoperoxidase as a novel bioactive nanocombination for colorectal cancer therapy
Authors: Nayl AbdElAziz A. , El-Fakharany Esmail M. , Abd-Elhamid Ahmed I. , Arafa Wael A. A. , Alanazi Ahmed H. , Ahmed Ismail M. , Abdelgawad Mohamed A. , Aly Ashraf A. , Bräse Stefan 
Published: October 2024

AbstractIt is imperative to explore new biocompatible drugs with low toxicity for use in medicinal fields such as fighting tumors. Bovine lactoperoxidase (BLPO) stems from the most important enzymes in the bovine whey that provide a proper pattern for nano-formulation with nanomaterials. LPO is a suitable protein to be coated or adsorbed to alginate modified graphene oxide (GO-SA), which forms the modified GO-SA-LPO hybrid structure. This novel combination provides LPO stability with strong anticancer effects and boosts immunity response. The characterization results obtained from different techniques confirmed a successful LPO adsorption on the GO-SA composite surface. Moreover, nano-formulation of LPO with GO-SA composite exhibited a reduction in its size and overall charge. In addition, the experimental results showed greater LPO activity stability in the modified GO-SA-LPO nanocombination than free LPO after storage for 10 weeks at 4 °C. The in vitro study, a crucial step in the validation of our approach, demonstrated that the modified GO-SA-LPO nanocombination showed a potent anticancer selectivity toward colon cancer cell lines more than GO-SA composite or free form of LPO, which enhanced in a dose-dependent manner with high safety manner against normal cells. The apoptotic effect of this novel nanocombination was confirmed by the greatest variations in the expression of both well-known apoptosis genes (p53 and Bcl-2), severe changes in the cellular morphology, DNA fragmentation, and nuclear staining with fluorescence yellow and orange of the target cancer cells. Also, this superior efficacy of the modified GO-SA-LPO nanocombination was induced by suppressing some pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and necrosis factor-kappa B (NF-ĸB). Our observations presented that the modified nanocombination of LPO may offer a novel remedy for treating colon tumors via induced apoptosis pathway, inflammation reduction, and immune response improvement.
A longitudinal study of facial function, quality of life, and depression in Bell’s palsy during pregnancy and puerperium
Authors: Lansing Lovisa , Brismar Wendel Sophia , Wejde Westlund Ellen , Marsk Elin 
Published: October 2024

AbstractBell’s palsy can reduce facial function and quality of life. Pregnancy may also be physically and psychologically challenging. This study investigates depression among pregnant and puerperal women with and without Bell’s palsy and if degree of facial palsy and depression was correlated. Thirty-one women with pregnancy-associated Bell’s and 31 women without Bell’s palsy were prospectively included and followed one year at two University Hospitals, Stockholm. Depression was assessed with Edinburgh Postnatal Depression Scale (EPDS). In women with Bell’s palsy, Facial Disability Index (FDI), Facial Clinimetric Evaluation (FaCE) scale, and Sunnybrook Facial Grading System (SFGS) were collected. The association between Bell’s palsy and EPDS ≥ 11 was assessed by logistic regression, and between EPDS and FDI, FaCE, and SFGS, respectively, by Spearman rank correlation. Median EDPS did not differ between groups (7.0 vs. 6.0, p = 0.74, one month, 6.5 vs. 6.0, p = 0.87, 12 months). EPDS at one month was correlated to FDI (p = 0.002) and FaCE (p = 0.004) and at 12 months to FDI (p = 0.009) but not to FaCE (p = 0.08). No correlation was found between EPDS and SFGS. In summary, no association appeared between pregnancy-associated Bell’s palsy and depression. Patient-reported function correlated well with depression in pregnancy-associated Bell’s palsy, while physician-reported facial function did not.
Development of a wastewater based infectious disease surveillance research system in South Korea
Authors: Kim Yun-Tae , Lee Kyungwon , Lee Hyukmin , Son Bokyung , Song Myeongwon , Lee Seung-Hyun , Kwon Miran , Kim Dong-Soo , Noh Tae-Hun , Lee Sanghoo , Kim Young-Jin , Lee Mi-Kyeong , Lee Kyoung-Ryul 
Published: October 2024

AbstractWastewater-based epidemiology has been used in pathogen surveillance for microorganisms at the community level. This study was conducted to determine the occurrence and trends of infectious pathogens in sewage from Yongin city and the relationships between these pathogens and the incidence of infectious diseases in the community. From December 2022 to November 2023, we collected inflow water from six wastewater treatment plants in Yongin city twice a month. The analyzed microorganisms included 15 respiratory viruses, 7 pneumonia-causing bacteria, 19 acute diarrhea-causing pathogens, SARS-CoV-2, Zika virus, hepatitis A virus, poliovirus, Mpox, and measles. They were detected through real-time PCR and conventional PCR. The concentrations of 9 pathogens among them were additionally analyzed using quantitative real time PCR. The correlation was confirmed through statistical analysis with the rate of detection for pathogens reported by the Korea Disease Control and Prevention Agency. Influenza A virus, human adenovirus, and human rhinovirus were moderately correlated (rho values of 0.45 to 0.58). Campylobacter spp. and sapovirus were strong correlated (rho values of 0.62, 0.63). Enteropathogenic E. coli, human coronavirus, and norovirus GII were very strong correlated (rho values of 0.86 to 0.92). We were able to identify the prevalence of respiratory viral infections, pneumonia, and acute diarrhea-causing pathogens in the community through wastewater-based epidemiology data. This study will be helpful in establishing a system for future surveillance of infectious diseases present in sewage.
Association of endometrial cancer risk with hypertension- an updated meta-analysis of observational studies
Authors: Drab Agnieszka , Kanadys Wiesław , Malm Maria , Wdowiak Krystian , Dolar-Szczasny Joanna , Barczyński Bartłomiej 
Published: October 2024

AbstractEndometrial cancer is one of the most common gynaecological cancers in the developed countries. The aim of this study was to determine the impact of hypertension on endometrial cancer risk. Databases: PubMed, Embase and the Cochrane Library were searched from January 2000 to June 2024. We used DerSimonian-Laird random-effects model for analysis. Risk estimates were extracted by two authors and summarized using meta-analytic methods. A total of 26 observational studies with 207,502 endometrial cancer cases were included in the study. Overall meta-analysis demonstrates significant association between hypertension and endometrial cancer risk (RR = 1.37, 95% CI: 1.27–1.47, p < 0.001). Subgroup analysis of the risk of endometrial cancer shows statistically significant higher risk in patients with BMI ≥ 30 kg/m2, diabetics, women who had their first menstrual period at the age of 11 years or earlier, and who had never given birth. Findings of this comprehensive review and meta-analysis indicate that hypertension is associated with higher overall risk of endometrial cancer.
A fungal phospholipase C involved in the degradation of plant glycosylinositol phosphorylceramides during Arabidopsis/Botrytis interaction
Authors: Lelas Luka , Rouffet Justine , Filachet Alexis , Sechet Julien , Davière Antoine , Desprez Thierry , Vernhettes Samantha , Voxeur Aline 
Published: October 2024

AbstractThis study investigates the presence and significance of phosphorylated oligosaccharides that accumulate during the interaction between Arabidopsis thaliana and Botrytis cinerea, a necrotrophic fungus that poses a major threat to crops worldwide. While previous research has extensively characterized cell wall-derived molecules during fungal infection, the role of plasma membrane-derived ones remains unclear. Here, we reveal the discovery of inositol phosphate glycans (IPGs) released during infection, originating from plant sphingolipids, specifically glycosylinositol phosphorylceramides (GIPC). Advanced chromatography, mass spectrometry techniques and molecular biology were employed to identify these IPGs, and determine their origins. In addition to the well-characterized role of B. cinerea in releasing cell wall-degrading enzymes, this research suggests that B. cinerea’s enzymatic machinery may also target the degradation of the plant plasma membrane. As a consequence of this, IPGs identical to those generated by the host plant are released, most likely due to activity of a putative phospholipase C that acts on GIPC plasma membrane lipids. These insights could pave the way for developing new strategies to enhance crop resistance by focusing on membrane integrity in addition to cell wall fortification.