bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foreign Direct Investment and Macroeconomic Factors: Evidence from the Indian Economy
Authors: Tripathi Vanita , Seth Ritika , Bhandari Varun 
Published: June 2017

Foreign direct investment (FDI) has boosted financial stability, growth and development in India. There has been positive growth rate in GDP since FDI in India has been allowed. FDI has also acted as the resistor during global financial crisis 2008. Many pull factors in India have attracted FDI which include rapidly expanding consumer market, easy access to other neighbouring countries, accessibility to cheaper basic inputs, well-developed and stable banking system and favourable policies for foreign investors, etc. This article attempts to find out the existence of relationship between FDI and six macroeconomic factors—Exchange rate (₹ per $), Inflation (WPI), GDP/IIP (proxy for Market size), Interest rate (91 days T-bills), Trade Openness and S&P CNX 500 Equity Index (profitability) using monthly and quarterly data for the period starting from July 1997 to December 2011. Apart from using the standard techniques, such as ADF and PP Unit root stationarity test, Bi-variate and Multi-variate Regression analysis and Granger Causality test, we have also applied advanced econometric techniques such as Johansen’s cointegration test, Vector Auto Regression (VAR) and Impulse Response analysis to check for long-run and short-run dynamic relationship. The results show a significant correlation between FDI and all macroeconomic variables (except for Exchange rate). Causality results show that IIP/GDP, WPI and S&P CNX 500 Equity Index are Granger causing FDI inflows in India while Trade Openness is Granger caused by the same. All the macroeconomic variables taken in the article (except exchange rate) are significantly affecting FDI inflows and the overall explanatory power of the regression model (i.e., Adjusted R square) is 75.7 per cent. The results of Johansen’s cointegration test disclose that there is long-run causal relation between FDI and IIP; FDI and S&P CNX 500 Equity, FDI and Trade Openness and FDI and WPI. VAR and Impulse response function analysis show that FDI is caused more by its own lagged values rather those of other macroeconomic factors. These results are important for policy makers, regulators and foreign investors. Policy makers and regulators are required to push reform agenda in domestic market for attracting huge FDI inflows in the country. Foreign investors want the policies of the country to be stable and transparent to provide enough safeguard for their investments because instability increases the risk to the foreign investors. Since, we find positive relationship between FDI and profitability, a higher investor’s confidence in domestic market acts as a stimulus in getting more FDI inflows.
HLA-DP in unrelated hematopoietic cell transplantation revisited: challenges and opportunities
Authors: Fleischhauer Katharina , Shaw Bronwen E. 
Published: June 2017

Abstract
When considering HLA-matched hematopoietic cell transplantation (HCT), sibling and unrelated donors (UDs) are biologically different because UD-HCT is typically performed across HLA-DP disparities absent in sibling HCT. Mismatched HLA-DP is targeted by direct alloreactive T cell responses with important implications for graft-versus-host disease and graft-versus-leukemia. This concise review details special features of HLA-DP as model antigens for clinically permissive mismatches mediating limited T-cell alloreactivity with minimal toxicity, and describes future avenues for their exploitation in cellular immunotherapy of malignant blood disorders.
A case of lenalidomide-dependent myelodysplastic syndrome
Authors: Miller Ira J. , Hsu Wei-Tong , Weisberger James , Venugopal Parameswaran 
Published: June 2017

Key Points
A man with cytopenias, dysplasia, excess blasts, P53 and RUNX1 mutations, and ring chromosome 7 recovered after stopping lenalidomide.
Analytically Sensitive Protein Detection in Microtiter Plates by Proximity Ligation with Rolling Circle Amplification
Authors: Ebai Tonge , Souza de Oliveira Felipe Marques , Löf Liza , Wik Lotta , Schweiger Caroline , Larsson Anders , Keilholtz Ulrich , Haybaeck Johannes , Landegren Ulf , Kamali-Moghaddam Masood 
Published: June 2017

Abstract

BACKGROUND
Detecting proteins at low concentrations in plasma is crucial for early diagnosis. Current techniques in clinical routine, such as sandwich ELISA, provide sensitive protein detection because of a dependence on target recognition by pairs of antibodies, but detection of still lower protein concentrations is often called for. Proximity ligation assay with rolling circle amplification (PLARCA) is a modified proximity ligation assay (PLA) for analytically specific and sensitive protein detection via binding of target proteins by 3 antibodies, and signal amplification via rolling circle amplification (RCA) in microtiter wells, easily adapted to instrumentation in use in hospitals.

METHODS
Proteins captured by immobilized antibodies were detected using a pair of oligonucleotide-conjugated antibodies. Upon target recognition these PLA probes guided oligonucleotide ligation, followed by amplification via RCA of circular DNA strands that formed in the reaction. The RCA products were detected by horseradish peroxidase-labeled oligonucleotides to generate colorimetric reaction products with readout in an absorbance microplate reader.

RESULTS
We compared detection of interleukin (IL)-4, IL-6, IL-8, p53, and growth differentiation factor 15 (GDF-15) by PLARCA and conventional sandwich ELISA or immuno-RCA. PLARCA detected lower concentrations of proteins and exhibited a broader dynamic range compared to ELISA and iRCA using the same antibodies. IL-4 and IL-6 were detected in clinical samples at femtomolar concentrations, considerably lower than for ELISA.

CONCLUSIONS
PLARCA offers detection of lower protein levels and increased dynamic ranges compared to ELISA. The PLARCA procedure may be adapted to routine instrumentation available in hospitals and research laboratories.
Integration of Slack, a cloud-based team collaboration application, into research coordination: a research letter
Authors: Gofine Miriam , Clark Sunday 
Published: June 2017

Background: Practitioners of epidemiology require efficient real-time communication and shared access to numerous documents in order to effectively manage a study. Much of this communication involves study logistics and does not require use of Protected Health Information. Slack is a team collaboration app; it archives all direct messages and group conversations, hosts documents internally, and integrates with the Google Docs application. Slack has both desktop and mobile applications, allowing users to communicate in real-time without the need to find email addresses or phone numbers or create contact lists. Method: We piloted the integration of Slack into our research team of one faculty member, one research coordinator, and approximately 20 research assistants. Statistics describing the app’s usage were calculated twelve months after its implementation. Results: Results indicating heavy usage by both research professionals and assistants are presented. our Slack group included a cumulative 51 users. Between October 2015 and November 2016, approximately 10,600 messages were sent through Slack; 53% were sent by RA’s and 47% were sent by us. Of the 106 files stored on Slack, 82% were uploaded by research staff. In a January 2016 survey, 100% of RA’s agreed or strongly agreed that Slack improved communication within the team. Conclusion: We demonstrate a model for integration of communication technology into academic activities by research teams. Slack is easily integrated into the workflow at an urban, academic medical center and is adopted by users as a highly effective tool for meeting research teams’ communication and document management needs.
SERVIÇO DE ATENDIMENTO FARMACÊUTICO AO IDOSO: PERSPECTIVA E PROPOSTAS
Authors: Santos Sandna Larissa Freitas dos , Pessoa Cinara Vidal , Alves Hérick Hebert da Silva , Borges Romênio Nogueira , Nogueira Torres Barros Karla Bruna 
Published: June 2017

O estudo teve como objetivo averiguar a perspectiva do profissional farmacêutico em realizar ações educativas para idosos da casa de apoio Remanso da Paz, Quixadá, CE. Trata-se de um estudo observacional, analítico, transversal, consistindo em uma abordagem quanti-qualitativa, realizado no mês de junho de 2016 com 23 idosos (57% mulheres).Os encontros aconteceram por meio de palestras informativas e educativas, através de um projeto de extensão SAFI - Serviço de Atendimento Farmacêutico ao paciente idoso pelos estudantes de Farmácia do Centro Universitário Católica de Quixadá. Dentre os temas abordados estavam: uso racional de medicamentos, uso de preparações caseiras de plantas medicinais, diabetes e hipertensão, problemas reumáticos, doenças cardiovasculares e respiratórias, e sedentarismo/alimentação. Foi realizada uma entrevista com um questionário correspondendo ao perfil sócio econômico dos idosos,e a informações sobre os medicamentos prescritos, bem como os utilizados pela prática da automedicação. Os idosos estavam na faixa etária entre 60 a 81 anos de idade, diagnosticados com hipertensão (50%), gastrite (19%), e diabetes (16%). A prática da automedicação foi relatada por 9 (40%) idosos e não foi mencionado efeito adverso causado pelo uso de medicamentos. Dentre o número total de 10 medicamentos 80% eram AINES com as queixas de uso entre dores de cabeça e no corpo. O farmacêutico foi visto como fonte de orientação sobre o uso de medicamentos em 13%. Com isso, ficou ressaltada a importância da orientação de ações de qualidade de vida ao idoso e a importância da atuação do Farmacêutico na saúde desse estrato da população.
Modified Port-Access Technique for the Treatment of Aortic Dissection after Previous Cardiac Surgery
Authors: Prifti Edvin , Demiraj Aurel , Xhaxho Roland 
Published: June 2017

One of the most challenging conditions to manage after previous cardiac surgery is chronic dissection of the ascending aorta. We operated on a 54-year-old man who had aortic dissection in addition to large aortic dimensions very close to the sternum, severe aortic regurgitation, and a false lumen in the descending aorta. We used a combination of perfusion and myocardial protection techniques, arising from port-access technology, that enabled antegrade flow into the aorta, endoclamping of the ascending aorta, the administration of cardioplegic solution before opening the sternum, and left ventricular venting to prevent ventricular distention. Our technique resulted in minimal blood loss, shorter circulatory-arrest and operative times, the ability to operate on a decompressed heart and descending aorta, good myocardial protection, and easier and safer access to the heart. Three years postoperatively, our patient was doing well.
Other patients might benefit from this approach; however, the surgeon must ensure that an aortic segment is suitable for endoclamping.
MSPD as sample preparation method for determination of selected pesticide residues in apples
Authors: Purdešová Andrea , Dömötorová Milena 
Published: June 2017

Abstract
A method for extraction and fast gas chromatographic (GC) determination of twenty pesticide residues of different volatility and polarity at ultratrace concentration level in apples is presented. Apples as representatives of non-fatty food were chosen as a matrix; they are also a common raw material for baby food production. Under fast GC conditions employing a mass spectrometric detector (MSD), several parameters of the MSPD procedure were optimised. Samples were homogenised with sorbent Florisil, pesticides were eluted with the optimised volume of etylacetate. After solvent evaporation to dryness, reconstitution of the rest to toluene follow and the final extract was injected. Recoveries obtained at three selected concentration levels were determined. The optimised procedure led to recoveries ≥ 90 % for the majority of the studied pesticides and the limits of quantification (LOQs) < 5 μg.kg-1. Repeatability of gas chromatography-mass spectrometry (GC-MS) measurements of the matrix matched standards, expressed as the relative standard deviation (RSD [%]), was in most cases acceptable for ultratrace concentration levels of pesticide residues.
Cyclic flow shop scheduling problem with two-machine cells
Authors: Bożejko Wojciech , Gnatowski Andrzej , Idzikowski Radosław , Wodecki Mieczysław 
Published: June 2017

Abstract
In the paper a variant of cyclic production with setups and two-machine cell is considered. One of the stages of the problem solving consists of assigning each operation to the machine on which it will be carried out. The total number of such assignments is exponential. We propose a polynomial time algorithm finding the optimal operations to machines assignment.
A brief review on the mode of action of antinematodal drugs
Authors: Abongwa Melanie , Martin Richard J. , Robertson Alan P. 
Published: June 2017

Abstract
Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.
Pulmonary Valve Insufficiency as a Complication of Radical Surgical Treatment of Tetralogy of Fallot
Authors: Stojanović Milovan , Deljanin-Ilić Marina , Vuković Aleksa , Petrović Dejan 
Published: June 2017

Summary
Tetralogy of Fallot is the most common cyanogenic congenital heart defect. The diagnosis is based on clinical signs, ECG examination, ultrasound examination of the heart, additional imaging methods and invasive testing. The therapeutic approach to the patient with tetralogy is complex and based on conservative and radical methods. Patients who have not undergone a radical surgical intervention have a poor prognosis, whereas the prognosis is much better for patients who have been operated. The most common complication of the surgical treatment is the pulmonary valve insufficiency which usually requires reintervention, as was the case with our patient.
Impact of the Irrigation Dose Amount on the Wheat Yield
Authors: Bieniek Jerzy , Mielnicki Marek , Romański Leszek , Komarnicki Piotr 
Published: June 2017

Abstract
The paper presents analysis of the impact of irrigation dose on the winter wheat Bystra yield, which is recommended for cultivation in Poland. It is a low-growing high-yield wheat cultivar. A reel sprinkler equipped with a computer for control of parameters of its operation, which was supplied with pond water was used for irrigation. Test were carried out on five fields, where four irrigation doses were used: 15, 20, 25, 30 mm. A change of weather during research in May and June caused the need to irrigate a field four times. During research, the size of the irrigation dose was measured with rain gauges on each of the investigated fields in five measurement points. One of the fields was a control field, which was not irrigated. The investigated wheat was characterized during harvesting. Research proved that the size of the irrigation dose influences the wheat yield. The grain yield between a control field and a field with the highest irrigation dose increased by twofold. Moreover, analysis of costs incurred during sprinkling were analysed.
Geometrical Model of Lemon Fruit
Authors: Mieszkalski Leszek 
Published: June 2017

Abstract
A proposal of a mathematical method of modelling of the lemon shape with Bézier's curves was presented. Lisbon, Verna, Genoa lemon cultivars were selected for verification of the modelling method. The lemon contour, which is its meridian, was described with three smoothly combined Bézier's curves. Pictures taken in 10 locations changing every 36o were the basis for description of lemon contours. Bézier's curves, which approximate meridians located on the surface of lemons, are their 3D models. The presented method may be applied for mathematical modelling of the lemon shape.
GNSS Antenna Caused Near-Field Interference Effect in Precise Point Positioning Results
Authors: Dawidowicz Karol , Baryła Radosław 
Published: June 2017

AbstractResults of long-term static GNSS observation processing adjustment prove that the often assumed “averaging multipath effect due to extended observation periods” does not actually apply. It is instead visible a bias that falsifies the coordinate estimation. The comparisons between the height difference measured with a geometrical precise leveling and the height difference provided by GNSS clearly verify the impact of the near-field multipath effect.The aim of this paper is analysis the near-field interference effect with respect to the coordinate domain. We demonstrate that the way of antennas mounting during observation campaign (distance from nearest antennas) can cause visible changes in pseudo-kinematic precise point positioning results. GNSS measured height differences comparison revealed that bias of up to 3 mm can be noticed in Up component when some object (additional GNSS antenna) was placed in radiating near-field region of measuring antenna. Additionally, for both processing scenario (GPS and GPS/GLONASS) the scattering of results clearly increased when additional antenna crosses radiating near-field region of measuring antenna. It is especially true for big choke ring antennas. In short session (15, 30 min.) the standard deviation was about twice bigger in comparison to scenario without additional antenna. When we used typical surveying antennas (short near-field region radius) the effect is almost invisible. In this case it can be observed the standard deviation increase of about 20%. On the other hand we found that surveying antennas are generally characterized by lower accuracy than choke ring antennas. The standard deviation obtained on point with this type of antenna was bigger in all processing scenarios (in comparison to standard deviation obtained on point with choke ring antenna).
Awareness of Improved Hatchery Management Practices among Fish Farmers in Lagos State
Authors: Digun-Aweto Oghenetejiri , Oladele Ademuyiwa Hafiz 
Published: June 2017

Abstract
During the last decade, hatchery infrastructure and table fish production systems have been exclusively targeted towards catfish production in Nigeria. These efforts have not translated to sufficient domestic fish production. The shortfall in demand for fish fry and fingerlings by growing population of fish farms in Lagos State confirms the fish seed production deficiency. This study investigated the level of awareness of improved hatchery management practices among fish farmers in Lagos State. Using simple random sampling method, 150 fish farmers from 12 local government areas of Lagos State were selected and interviewed using a structured questionnaire. The majority of the respondents were male (68 %) and married (76.6 %), with dominant age range of 41–50 years (55.3 %) and a farming experience of 5–10 years (68 %). Personal saving (46.7 %) and cooperative societies (31.3 %) were the respondents’ main sources of fund and fortnight visits by extension agent was of commonest frequency (86 %). Extension agents and research institutes ranked first and second, respectively, among the sources of information, and accounted for the main sources of information to the farmers. The farmers either strongly agreed or agreed on almost all the hatchery management practices, while they expressed their need for advisory and input support services from government and non-governmental organizations. The significant relationship which exists between age and marital status, and farmers’ awareness shows that greater communication of improved hatchery management practices will lead to adoption, thereby increasing the output of the farmers. Improved hatchery output will lead to greater availability of fish seeds for table size production as well as greater income to the fish farmers. In addition to more intensive extension efforts, other channels of information notably mass media should be revitalized in delivering improved management practices to the fish farmers.
Stability of fractional positive continuous-time linear systems with state matrices in integer and rational powers
Authors: Kaczorek T. 
Published: June 2017

AbstractThe stability of fractional standard and positive continuous-time linear systems with state matrices in integer and rational powers is addressed. It is shown that the fractional systems are asymptotically stable if and only if the eigenvalues of the state matrices satisfy some conditions imposed on the phases of the eigenvalues. The fractional standard systems are unstable if the state matrices have at least one positive eigenvalue.
Review on Big Data & Analytics – Concepts, Philosophy, Process and Applications
Authors: Venkatram Kari , Geetha Mary A. 
Published: June 2017

Abstract
Big Data analytics has been the main focus in all the industries today. It is not overstating that if an enterprise is not using Big Data analytics, it will be a stray and incompetent in their businesses against their Big Data enabled competitors. Big Data analytics enables business to take proactive measure and create a competitive edge in their industry by highlighting the business insights from the past data and trends. The main aim of this review article is to quickly view the cutting-edge and state of art work being done in Big Data analytics area by different industries. Since there is an overwhelming interest from many of the academicians, researchers and practitioners, this review would quickly refresh and emphasize on how Big Data analytics can be adopted with available technologies, frameworks, methods and models to exploit the value of Big Data analytics.
Study of kallikrein-related peptidase 6 (KLK6) and its complex with α1-antitrypsin in biological fluids
Authors: Korbakis Dimitrios , Soosaipillai Antoninus , Diamandis Eleftherios P. 
Published: June 2017

AbstractBackground:Human kallikrein-related peptidase 6 (KLK6) is a member of the kallikrein family of serine proteases. KLK6 is synthesized as a preproenzyme, mainly in tissues of the central nervous system (CNS), and secreted as an inactive precursor. Serum KLK6 is a biomarker of unfavorable prognosis for ovarian cancer, but its sensitivity for early detection is relatively low. Differential glycosylation of KLK6 has been identified in ascites fluid obtained from ovarian cancer patients, suggesting the presence of unique KLK6 isoforms in biological samples.Methods:In the present study, we applied a two-step enrichment approach for KLK6 in ovarian cancer ascites, followed by mice immunization and production of monoclonal antibodies. Immunoaffinity techniques coupled to mass spectrometric methods were employed for hybridoma screening and target antigen identification.Results:We found that the main target of the newly-generated monoclonal antibodies target was the serine protease inhibitor αConclusions:We conclude that KLK6 is present in biological fluids either as free form, or bound to A1AT, and the bound form performs better than total KLK6 as a biomarker of ovarian carcinoma.