bluuebunny/crossref_metadata_2025_split huggingface dataset:
Group relative deprivation and different forms of political actions: The role of the target outgroup
Authors: PAVLOVIĆ TOMISLAV , STORM INGRID , FRANC RENATA 
Published: October 2024

AbstractMany contemporary researchers agree that group relative deprivation is a driver of political actions against outgroups. However, both relative deprivation and political actions are complex phenomena, making it important to further study this relationship in the context of other relevant variables. One such variable could be the specific outgroup. The purpose of our study was to evaluate differences in the contribution of group relative deprivation to the prediction of activist and radicalised intentions against two outgroups – Muslims and senior citizens. The multi‐group structural equation modelling was applied separately on nationally representative samples of youth from Germany (N = 1,056), Norway (N = 376) and the United Kingdom (UK) (N = 1053). Group relative deprivation exhibited a robust relationship with activist intentions after controlling for general aggression, social desirability bias, age and gender, except in the UK, where the relationship between activist intentions and relative deprivation was stronger with Muslims as the target outgroup. The relationship between relative deprivation and radicalised intentions depended on the target outgroup across countries – it was related to radicalised intentions only against Muslims. The meaning and implications of these results are briefly discussed.
Sublethal concentration of λ‐cyhalothrin inhibits insulin‐like peptides and leads to reproductive toxicity in Chrysoperla sinica
Authors: Wang Nianmeng , Wang Zijian , Gong Siyuan , Zhang Yashu , Xue Chaobin 
Published: October 2024

AbstractInsulin‐like peptides (ILPs) act as crucial reproductive neuropeptides in insects, regulating insect reproduction through the insulin signaling pathway (ISP). Our previous studies have found that the sublethal concentrations (LC1 and LC10) of lambda‐cyhalothrin (λCy) could induce severe reproductive toxicity in the lacewing, Chrysoperla sinica (Tjeder), but the toxicological mechanism remains unclear. This study discovered that λCy could inhibit CsILP transcription, leading to a decrease in insulin content and downregulation of C. sinica insulin receptor (CsInR) and C. sinica forkhead box O (CsFOXO) expression in ISP. Interference with CsILP expression resulted in downregulation of C. sinica vitellogenin (CsVg) and decreasing fecundity, while exogenous injection of bovine insulin promoted upregulation of CsVg expression and facilitated reproduction in female adults of C. sinica. Meanwhile, interference with FOXO of ILP downstream transcription factor could lead to downregulation of CsVg, hindering ovarian development and resulting in a decrease in egg production. However, exogenous injection of bovine insulin could remedy the effects caused by FOXO interference. In addition, ILP mediates juvenile hormone and 20‐hydroxyecdysone biosynthesis by acting on their synthetic regulatory enzymes and influences the signal transduction of the 2 reproductive endocrine hormones, thereby regulating the reproductive endocrine environment in C. sinica. In conclusion, λCy inhibits CsILP expression, leading to disorder of ISP, leading to the reduced fecundity of C. sinica.
Bounded professionalism nexus: HR professionalism within and across organizational boundaries
Authors: Nadiv Ronit , Kuna Shani 
Published: October 2024

AbstractEven though the field of human resources is rife with tensions and contradictions, little is known about how HR practitioners experience and navigate these challenges. The impact of these tensions and ambiguities on HR professionalism remains understudied. Using the framework of “bounded professionalism”, this study explores how HR practitioners in business organizations (RBOs) and staffing agencies (RSAs) navigate professional and organizational tensions. Through a qualitative methodology, we conducted 60 semi‐structured interviews with HR practitioners from a variety of organizational settings. By examining the complicated experiences of HR practitioners, we highlight the nuanced ways in which they manage and mitigate professional and organizational tensions. This paper introduces and further develops the concept of “bounded professionalism nexus,” which implies that collaboration between professionals across organizational boundaries may exacerbate the experience of bounded professionalism. Specifically, we identify the triggers and implications of “bounded professionalism nexus”, demonstrating how cross‐border organizational relations contribute to suboptimal performance in both RSAs and RBOs. According to our findings, these tensions are not only prevalent, but also have significant implications for HR professionalism. This study concludes by examining the broader implications of the “bounded professionalism nexus” for HR professionals and offering suggestions for mitigating these tensions.
Acidophilic sulphate‐reducing bacteria: Diversity, ecophysiology, and applications
Authors: Valdez‐Nuñez Luis Felipe , Kappler Andreas , Ayala‐Muñoz Diana , Chávez Idelso Jamín , Mansor Muammar 
Published: October 2024

AbstractAcidophilic sulphate‐reducing bacteria (aSRB) are widespread anaerobic microorganisms that perform dissimilatory sulphate reduction and have key adaptations to tolerate acidic environments (pH <5.0), such as proton impermeability and Donnan potential. This diverse prokaryotic group is of interest from physiological, ecological, and applicational viewpoints. In this review, we summarize the interactions between aSRB and other microbial guilds, such as syntrophy, and their roles in the biogeochemical cycling of sulphur, iron, carbon, and other elements. We discuss the biotechnological applications of aSRB in treating acid mine drainage (AMD, pH <3), focusing on their ability to produce biogenic sulphide and precipitate metals, particularly in the context of utilizing microbial consortia instead of pure isolates. Metal sulphide nanoparticles recovered after AMD treatment have multiple potential technological uses, including in electronics and biomedicine, contributing to a cost‐effective circular economy. The products of aSRB metabolisms, such as biominerals and isotopes, could also serve as biosignatures to understand ancient and extant microbial life in the universe. Overall, aSRB are active components of the sulphur and carbon cycles under acidic conditions, with potential natural and technological implications for the world around us.
Insulin requirement trajectories during COVID‐19 versus non‐COVID‐19 critical illness—A retrospective cohort study
Authors: Soltani Navid , Häbel Henrike , Balintescu Anca , Lind Marcus , Grip Jonathan , Thobaben Ragnar , Nelson David , Mårtensson Johan 
Published: October 2024

AbstractBackgroundThe glycemic response to critical COVID‐19 remains uncertain. We aimed to assess the association between COVID‐19, insulin requirements, glycemic control, and mortality in intensive care unit (ICU) patients.MethodsWe conducted a retrospective observational study of 350 COVID‐19 patients and 1067 non‐COVID‐19 patients admitted to the ICU. Insulin requirement was defined as the total units of exogenous insulin required to cover one gram of administered carbohydrates (insulin‐to‐carbohydrate ratio, ICR). We used multivariable generalized linear mixed‐model (GLMM) analysis to assess the association of the interaction between COVID‐19 and ICU‐day with daily ICR, adjusted for fixed and time‐dependent covariates. Glycemic control was assessed after stratification on diabetes and COVID‐19. We used multivariable logistic regression analysis to assess the association between ICR and 90‐day mortality.ResultsThe mean (95% CI) of the mean daily ICR among patients without diabetes was 0.09 (0.08–0.11) U/g and 0.15 (0.11–0.18) U/g in the non‐COVID‐19 group and COVID‐19 group (p = .01), respectively. In diabetes patients, the corresponding ICRs were 0.52 (0.43–0.62) U/g and 0.59 (0.50–0.68) U/g (p = .32). In multivariable GLMM analysis, the interaction between COVID‐19 and ICU‐day was independently associated with ICR (risk estimate 1.22, 95% CI 1.15–1.31, p < .001). COVID‐19 was associated with higher hypoglycemia prevalence irrespective of diabetes status, higher average glucose levels, more pronounced glucose variability, and a lower proportion of glucose values within target range among patients without diabetes. On multivariable logistic regression analysis, the adjusted odds ratio for 90‐day mortality was 1.77 (95% CI 0.94–3.34, p = .076) per one unit increase in mean ICR.ConclusionIn our cohort of ICU patients, COVID‐19 was associated with higher daily insulin requirements per gram of administered carbohydrates, and worse glycemic control. We found no robust association between ICR and increased odds of death at 90 days.
Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro‐anabolic mediators
Authors: Maurer Svenja , Kirsch Valeria , Ruths Leonie , Brenner Rolf E. , Riegger Jana 
Published: October 2024

AbstractCellular senescence is associated with various age‐related disorders and is assumed to play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a senolytic combination therapy using Dasatinib (D) and Quercetin (Q) on aged isolated human articular chondrocytes (hACs), as well as in OA‐affected cartilage tissue (OARSI grade 1–2). Stimulation with D + Q selectively eliminated senescent cells in both, cartilage explants and isolated hAC. Furthermore, the therapy significantly promoted chondroanabolism, as demonstrated by increased gene expression levels of COL2A1, ACAN, and SOX9, as well as elevated collagen type II and glycosaminoglycan biosynthesis. Additionally, D + Q treatment significantly reduced the release of SASP factors (IL6, CXCL1). RNA sequencing analysis revealed an upregulation of the anabolic factors, inter alia, FGF18, IGF1, and TGFB2, as well as inhibitory effects on cytokines and the YAP‐1 signaling pathway, explaining the underlying mechanism of the chondroanabolic promotion upon senolytic treatment. Accordingly, stimulation of untreated hAC with conditioned medium of D + Q‐treated cells similarly induced the expression of chondrogenic markers. Detailed analyses demonstrated that chondroanabolic effects could be mainly attributed to Dasatinib, while monotherapeutical application of Quercetin or Navitoclax did not promote the chondroanabolism. Overall, D + Q therapy restored the chondrogenic phenotype in OA hAC most likely by creating a pro‐chondroanabolic environment through the reduction of SASP factors and upregulation of growth factors. This senolytic approach could therefore be a promising candidate for further testing as a disease‐modifying osteoarthritis drug.
Rare but relevant: Cannabinoid hyperemesis syndrome
Authors: Stjepanović Daniel , Kirkman Julia , Hall Wayne 
Published: October 2024

AbstractCannabinoid hyperemesis syndrome (CHS) is a (probably) rare syndrome that occurs in frequent and chronic cannabis users. It is characterised by cyclical vomiting and gastrointestinal symptoms. CHS is frequently misdiagnosed resulting in extensive investigations and delayed diagnosis and treatment. Standard anti‐emetic treatments are typically not effective, and no standardised treatment protocol exists for CHS. Bathing or showering in hot water is often reported to relieve symptoms. Little is known of the aetiology of CHS as the literature is predominantly informed by case reports and chart reviews. Similarly, little is known of the demographics and cannabis use patterns of those who develop CHS. The number of CHS cases globally appears to have risen following liberalisation of cannabis regulation and access in some countries, underscoring the need for wider recognition of CHS in emergency care and by the wider public.
The impact and mechanisms of parent–child relationship quality and its changes on adolescent depression: A four‐wave longitudinal study
Authors: Li Jinwen , Qian Kun , Liu Xia 
Published: October 2024

AbstractParent–child relationships play a crucial role in shaping adolescent depression. However, existing research has predominantly focused on isolated time points when examining the impact of parent–child relationship quality, overlooking the effect of parent–child relationship changes on depression. Using a four‐wave longitudinal study of 951 adolescents, the current study investigated the impact of parent–child relationship quality and its changes on adolescent depression, while also examining the moderating role of interpersonal sensitivity and potential gender differences in these moderation patterns. Herein, we report that higher parent–child relationship quality is associated with lower levels of adolescent depression, while parent–child relationship changes are linked to higher depression. Interpersonal sensitivity moderates the association between parent–child relationship quality, relationship changes, and depression, with the moderation varying by gender. Specifically, in males with high interpersonal sensitivity, parent–child relationships negatively predict depression, while relationship fluctuations positively predict depression. In females with high interpersonal sensitivity, a rapid decline in the quality of the parent–child relationship seems to be associated with an increase in depression. The present study highlights the impact and mechanisms of parent–child relationship quality and its effects on depression, and provides a reference for the intervention of depression based on parent–child relationship changes.
Effect of healthy dietary intention‐behavior (in)consistency on depression and anxiety in the process of behavior change
Authors: Lin Jiaci , Yang Fuhua , Pu Kunhua , Lan Miaosen , Chen Yichun , Yin Keli 
Published: October 2024

AbstractAlthough an increasing number of people are now committed to pursuing a healthy diet, it remains unclear how mental health changes during this process. The present study aimed to examine the combined effect of healthy dietary intention and behavior on depression and anxiety across two sub‐studies. This study consisted of two parts: a cross‐sectional survey (Study 1) involving 1,433 college students and an 11‐day daily diary study (Study 2) with 117 college students. Polynomial regression and response surface analysis indicated that in cases of congruence, individuals' intention and behavior align at a high level and were associated with lower levels of depression and anxiety in the motivational phase but were not found similar association in the volitional phase. In cases of incongruence, individuals with high intention‐low behavior tend to experience lower levels of depression and anxiety in the motivational phase. However, individuals with high intention‐low behavior tend to experience higher levels of depression and anxiety in the volitional phase. These findings not only enrich the current understanding of diet and health but also contribute to the development of holistic strategies for promoting a healthy diet.
Housing instability amongst takatāpui and LGBTIQ+ people in Aotearoa New Zealand
Authors: Fraser Brodie 
Published: October 2024

AbstractAlthough awareness and understanding of LGBTIQ+ people's experiences of homelessness are rising, their broader housing experiences remain under‐researched. This paper uses qualitative interview data to explore takatāpui and LGBTIQ+ people's experiences of housing instability in Aotearoa New Zealand. In expanding the focus to housing instability, this paper explores how LGBTIQ+ people experience and navigate the housing system, which sheds light on the upstream factors that contribute to the disproportionately high rates of homelessness amongst LGBTIQ+ communities worldwide. A reflexive thematic analysis of the data generated four themes to takatāpui and LGBTIQ+ people's experiences of housing instability; personal experiences are political, survival within inequitable systems is nuanced, instability is relational, and selfhood is mediated through instability. These results highlight the impact of policy and structural failures on LGBTIQ+ communities.
The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion
Authors: Jayne Sandrine , López Cristina , Put Natalie , Nagel Inga , Lierman Els , Penas Eva Maria Murga , Michaux Lucienne , Ahearne Matthew J. , Walter Harriet S. , Bens Susanne , Drewes Cosima , Szczepanowski Monika , Schlesner Matthias , Rosenstiel Philip , Wlodarska Iwona , Siebert Reiner , Dyer Martin J. S. 
Published: October 2024

SummaryThe chromosomal translocation t(1;6)(p35.3;p25.2) is a rare but recurrent aberration in chronic lymphocytic leukaemia (CLL). We report molecular characterization of 10 cases and show that this translocation juxtaposes interferon regulatory factor 4 (IRF4) on 6p25 with regulator of chromosome condensation 1 (RCC1) on 1p35. The breakpoints fell within the 5′ untranslated regions of both genes, resulting in RCC1::IRF4 fusion transcripts without alterations of the protein‐coding sequences. Levels of expression of both RCC1 and IRF4 proteins were not obviously deregulated. The cases showed other mutations typical of CLL and we confirm previously reported skewing towards the IGHV‐unmutated subtype. RCC1::IRF4 fusion characterizes a rare subset of CLL.
On a general theoretical framework of reliability
Authors: Liu Yang , Pek Jolynn , Maydeu‐Olivares Alberto 
Published: October 2024

AbstractReliability is an essential measure of how closely observed scores represent latent scores (reflecting constructs), assuming some latent variable measurement model. We present a general theoretical framework of reliability, placing emphasis on measuring the association between latent and observed scores. This framework was inspired by McDonald's (Psychometrika, 76, 511) regression framework, which highlighted the coefficient of determination as a measure of reliability. We extend McDonald's (Psychometrika, 76, 511) framework beyond coefficients of determination and introduce four desiderata for reliability measures (estimability, normalization, symmetry, and invariance). We also present theoretical examples to illustrate distinct measures of reliability and report on a numerical study that demonstrates the behaviour of different reliability measures. We conclude with a discussion on the use of reliability coefficients and outline future avenues of research.
Identification of sequence polymorphism in the D‐loop region of mitochondrial DNA as a risk factor for breast cancer
Authors: Nie Qian , Zhang Wenzhe , Lin Songping , Huang Meng , Li Yan , Qiu Yibin , Li Jing , Chen Xiaobin , Wang Yali , Tong Xin , Wu Jinqiao , He Peng , Cai Qindong , Chen Lili , Chen Minyan , Guo Wenhui , Lin Yuxiang , Yu Liuwen , Hou Jialin , Cai Weifeng , Chen Hanxi , Wang Chuan , Fu Fangmeng 
Published: October 2024

AbstractMitochondrial DNA (mtDNA) variations affect the efficiency of the electron transport chain and production of reactive oxygen species, contributing to carcinogenesis. The D‐loop region of mtDNA has emerged as a variation hotspot region in human neoplasia; however, the potential contribution of these variations in breast cancer risk prediction remains unknown. We investigated the relationship between germline single nucleotide polymorphisms (SNPs) in the entire D‐loop region and breast cancer risk in Chinese women. Peripheral blood‐isolated mtDNA from 2329 patients with breast cancer and 2328 cancer‐free controls was examined for SNPs. In the combined cohort, we used traditional risk factors, susceptibility germline polymorphisms, and logistic regression analysis to evaluate the predictive value of susceptibility variants for breast cancer risk. We calculated the area under the receiver operating characteristic curve (AUC) as a measure. We also measured the content of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG). Individual polymorphisms SNP573 were significantly associated with breast cancer risk in both the discovery and validation cohorts. In the combined cohort, the AUC of the traditional risk factors was 64.3%; after adding susceptibility variants, the AUC was 64.9% (DeLong test, p = 0.007). 8‐OHdG levels were significantly higher in patients with breast cancer than in controls and higher in individuals with SNP573 than in those negative for this variation. Overall, oxidative stress might be associated with the risk of breast cancer, and SNP573 might be associated with oxidative stress. Our results indicate the risk potential of polymorphisms in the D‐loop region in breast cancer in Southern China.
ME2 Deficiency Is Associated With Recessive Neurodevelopmental Disorder
Authors: Almontashiri Naif A. M. , Alharby Essa , Saleh Mohammed , Abu‐Farha Mohamed , Alasmari Ali , Gebbia Marinella , Hiesl Charlotte , Peake Roy W. A. , Amr Sami Samir , Boles Eckhard , Roth Frederick P. , Abubaker Jehad 
Published: October 2024

ABSTRACTMalate is an important dicarboxylic acid produced from fumarate in the tricarboxylic acid cycle. Deficiencies of fumarate hydrolase (FH) and malate dehydrogenase (MDH), responsible for malate formation and metabolism, respectively, are known to cause recessive forms of neurodevelopmental disorders (NDDs). The malic enzyme isoforms, malic enzyme 1 (ME1) and 2 (ME2), are required for the conversion of malate to pyruvate. To date, there have been no reports linking deficiency of either malic enzyme isoforms to any Mendelian disease in humans. We report a patient presenting with NDD, subtle dysmorphic features, resolved dilated cardiomyopathy, and mild blood lactate elevation. Whole exome sequencing (WES) revealed a homozygous frameshift variant (c.1379_1380delTT, p.Phe460fs*22) in the malic enzyme 2 (ME2) gene resulting in truncated and unstable ME2 protein in vitro. Subsequent deletion of the yeast ortholog of human ME2 (hME2) resulted in growth arrest, which was rescued by overexpression of hME2, strongly supporting an important role of ME2 in mitochondrial function. Our results also support the pathogenicity and candidacy of the ME2 gene and variant in association with NDD. To our knowledge, this is the first report of a Mendelian human disease resulting from a biallelic variant in the ME encoding gene. Future studies are warranted to confirm ME2‐associated recessive NDD.