bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelvic inflammatory disease and risk of borderline ovarian tumors: A national population‐based case–control study in Sweden
Authors: Jonsson Sarah , Jonsson Håkan , Lundin Eva , Häggström Christel , Idahl Annika 
Published: September 2024

AbstractThe resemblance between fallopian tube cells and serous borderline ovarian tumors (BOTs) suggests a potential origin link, with salpingitis proposed as a contributing factor in the pathogenesis of BOT. This study aimed to explore the potential association between pelvic inflammatory disease (PID) and the risk of developing BOT. A national population‐based case–control study in Sweden included women with BOT between 1999 and 2020 and 10 matched controls. Data from nationwide registers were analyzed using conditional logistic regression, adjusting for age, residential district, educational level and parity. Among 4782 cases and 45,167 controls, 2.0% of cases and 1.3% of controls had a history of PID. Previous PID was associated with an increased risk of BOT overall (aOR, 1.48; 95% CI, 1.19–1.85). Significant association was observed with serous tumors (aOR, 1.76; 95% CI, 1.36–2.29), while not with mucinous tumors (aOR, 0.95; 95% CI, 0.60–1.49). A dose–response relationship between number of PID episodes and serous BOT risk was noted (Ptrend < .001). This study demonstrates that PID is associated with increased risk of serous BOT, with a dose response relationship. The study highlights the potential serious implications of upper reproductive tract infections and inflammation. This underscores the need for further investigation of biological mechanisms and possible impact of PID on serous BOT development.
Soluble CD206 in metastatic renal cell carcinoma: Relation to clinical–biochemical parameters and patient outcome
Authors: Lauridsen Kasper Munch , Møller Holger Jon , Kristensen Mie Wolff , Fristrup Niels , Donskov Frede , Hokland Marianne , Andersen Morten Nørgaard 
Published: September 2024

AbstractThe mannose receptor (MR/CD206) is a marker of M2‐like tumor‐associated macrophages. Membrane CD206 can be shed, releasing the receptor as a soluble protein (sCD206), which can be measured in serum. Here, we investigated the biomarker potential of sCD206 in patients with metastatic renal cell carcinoma (mRCC). Serum sCD206 was measured by an enzyme‐linked immunosorbent assay in 88 mRCC patients and 20 healthy controls (HCs). At diagnosis, serum sCD206 was elevated in patients with intermediate‐risk mRCC according to the Memorial Sloan Kettering Cancer Center (MSKCC) risk score, compared to both HCs and patients with favorable MSKCC risk score. Furthermore, sCD206 levels correlated with both sCD163 and C‐reactive protein. Soluble CD206 levels decreased after treatment initiation (p < .0001 at 5 weeks) but with a tendency toward elevated levels at time of progression, compared to baseline (p = .06). In univariate survival analysis, high levels of serum sCD206 at baseline was a significant risk factor associated with reduced overall survival (hazard ratio [HR] = 1.37, 95% confidence interval: 1.12–1.67, p = .002). Stratified by clinical risk scores, increased sCD206 was still a statistically significant risk factor of overall mortality (p < .01) in the intermediate‐risk group by both the MSKCC (HR = 1.48) and the newer International Metastatic RCC Database Consortium (IMDC) score (HR = 1.53). Furthermore, addition of sCD206 as a dichotomized variable to the IMDC risk score enabled separation of the intermediate‐risk group into two groups with survival comparable to those with favorable and poor risk, respectively. Overall, sCD206 is a potential add‐on biomarker for mRCC patients in the intermediate‐risk group of the current clinical risk scores.
Impact of age on premenstrual syndrome prevalence and severity: A population‐based survey in Brazil
Authors: Pedro Adriana Orcesi , Brandão Juliana Dineia Perez , de Oliveira Silva Samantha Belamarques , Lapa Maura Gonzaga , Castilho Vivienne Carduz 
Published: September 2024

AbstractObjectiveTo evaluate the relationship between premenstrual disorders (PMD) and age, we analyzed the prevalence and severity of psycho‐emotional and physical symptoms in a representative sample of Brazilian women.MethodsThis observational and retrospective study analyzed data from Brazilian women aged 20–49 years from five regions of the country who reported premenstrual symptoms. Participants completed a premenstrual symptom screening questionnaire and self‐reported the presence and severity of their symptoms. Among 23 104 women reporting does premenstrual symptoms, 38.91% (n = 8990) experienced PMD caused functional impairment. Finally, 5121 participants agreed to complete the adapted version of the screening questionnaire.ResultsThe age group distribution was 20–29 (46.7%), 30–39 (38.3%), and 40–49 years (15%). The most prevalent and severe physical symptom was acne/oily skin in participants aged 20–29 years and headache in women aged 30–49 years. Regarding psycho‐emotional symptoms, the most prevalent was anxiety/tension in women aged 20–29 years and 40–49 years and irritability/anger in those aged 30–39 years. Irritability/anger was the most severe symptom in all groups.ConclusionPMD significantly impacts the quality of life of Brazilian women with varying intensity. Physical symptoms associated with PMD vary with age, while psycho‐emotional symptoms, particularly irritability/anger and anxiety, were intense in Brazilian women of reproductive age. These findings inform early diagnosis and individualized treatment approaches for PMD, addressing the needs of women.
RetNet30: A Novel Stacked Convolution Neural Network Model for Automated Retinal Disease Diagnosis
Authors: Subramaniam Krishnakumar , Naganathan Archana 
Published: September 2024

ABSTRACTAutomated diagnosis of retinal diseases holds significant promise in enhancing healthcare efficiency and patient outcomes. However, existing methods often lack the accuracy and efficiency required for timely disease detection. To address this gap, we introduce RetNet30, a novel stacked convolutional neural network (CNN) designed to revolutionize automated retinal disease diagnosis. RetNet30 combines a custom‐built 30‐layer CNN with a fine‐tuned Inception V3 model, integrating these sub‐models through logistic regression to achieve superior classification performance. Extensive evaluations on retinal image datasets such as DRIVE, STARE, CHASE_DB1, and HRF demonstrate significant improvements in accuracy, sensitivity, specificity, and area under the ROC curve (AUROC) when compared to conventional approaches. By leveraging advanced deep learning architectures, RetNet30 not only enhances diagnostic precision but also generalizes effectively across diverse datasets, establishing a new benchmark in retinal disease classification. This novel approach offers a highly efficient and reliable solution for early disease detection and patient management, addressing the limitations of manual examination methods. Through rigorous quantitative and qualitative assessments, our proposed method demonstrates its potential to significantly impact medical image analysis and improve healthcare outcomes. RetNet30 marks a major step forward in automated retinal disease diagnosis, showcasing the future of AI‐driven advancements in ophthalmology.
Serving as a professional association board member: Benefits to leaders and their employers
Authors: Erstad Brian L. , Jacobi Judith , Kehoe William A. , Nesbit Suzanne A. , Seaton Terry L. 
Published: September 2024

AbstractThis commentary, written by past presidents of the American College of Clinical Pharmacy, highlights the benefits of serving in leadership roles within professional associations to the leaders themselves, their employers, their colleagues, and the broader profession. Fostering the development of leaders is a necessary step to advance pharmacy's future. Leaders benefit not only from the reinvigoration and personal growth associated with their service effort but also from the further development of skills such as collaboration and consensus‐building, written and oral communication, critical thinking, leadership, and time management. The honing of these skills has benefits at the leader's workplace. Colleagues in businesses outside health care view this type of leadership experience as external training to develop and refine organizational communication and leadership skills and better prepare their employees for the future. The leader also learns best practices and new perspectives that, when shared locally, can energize the employer organization. Beyond the benefits to the leader and the leader's employer, there are holistic benefits of association service to the profession and interprofessional teams. With this in mind, we suggest that employers welcome opportunities to have their coworkers serve in elected or appointed positions within professional associations.
Novel 3D printed bioactive SiC orthopedic screw promotes bone growth associated activities by macrophages, neurons, and osteoblasts
Authors: El‐Ghannam Ahmed , Sultana Farjana , Dréau Didier , Tiwari Arjun , Yang In Hong , AlFotawi Randa , Knabe‐Ducheyne Christine 
Published: September 2024

AbstractCeramic additive manufacturing currently relies on binders or high‐energy lasers, each with limitations affecting final product quality and suitability for medical applications. To address these challenges, our laboratory has devised a surface activation technique for ceramic particles that eliminates the necessity for polymer binders or high‐energy lasers in ceramic additive manufacturing. We utilized this method to 3D print bioactive SiC orthopedic screws and evaluated their properties. The study's findings reveal that chemical oxidation of SiC activated its surface, enabling 3D printing of orthopedic screws in a binder jet printer. Post‐processing impregnation with NaOH and/or NH4OH strengthened the scaffold by promoting silica crystallization or partial conversion of silicon oxide into silicon nitride. The silica surface of the SiC 3D printed orthopedic screws facilitated osteoblast and neuron adhesion and extensive axon synthesis. The silicate ions released from the 3D printed SiC screws favorably modulated macrophage immune responses toward an M1 phenotype as indicated by the inhibition of TNFα secretions and of reactive oxygen species (ROS) expression along with the promotion of IL6R shedding. In contrast, under the same experimental conditions, Ti ions released from Ti6Al4V discs promoted macrophage TNFα secretion and ROS expression. In vivo tests demonstrated direct bone deposition on the SiC scaffold and a strong interfacial bond between the implanted SiC and bone. Immunostaining showed innervation, mineralization, and vascularization of the newly formed bone at the interface with SiC. Taken altogether, the 3D printed SiC orthopedic screws foster a favorable environment for wound healing and bone regeneration. The novel 3D printing method, based on ceramic surface activation represents a significant advancement in ceramic additive manufacturing and is applicable to a wide variety of materials.
The LTAR Cropland Common Experiment at Upper Mississippi River Basin–Morris
Authors: Johnson Jane M. F. , Helseth Christina M. , Weyers Sharon , Papanicolaou Thanos , Busche Dennis 
Published: September 2024

AbstractThe Upper Mississippi River Basin (UMRB) Long‐Term Agroecosystem Research (LTAR) watershed is hydrologically complex, with a notable temperature and precipitation gradient across four locations: Ames, IA; Platteville, WI; Morris, MN; and St. Paul, MN. Each location established LTAR Croplands Common Experiment (CCE) scenarios to fit local climatic and cultural practices. This paper describes the UMRB‐Morris location, which was established in 2016 and is the most northern of the sites and contributes to the major watersheds of the UMRB and the Red River of the North. Both on‐farm and plot‐scale studies are included. The prevailing system is a corn (Zea mays L.)–soybean (Glycine max L.) rotation with annual deep ripping tillage. The signature alternative system is alternative 1, which is a shallow strip‐till in a corn–soybean rotation. A second alternative system includes shallow tillage/rotational no‐tillage in a corn–soybean–wheat (Triticum aestivum L.) with winter oilseed and cover crops, and it is considered a test ground for future alternative systems. On‐farm fields are equipped with eddy covariance towers and include 16 geo‐referenced soil core sampling sites for incremental samplings. Each field is sampled annually for crop yield and management data are recorded. Plot‐scale versions of the treatments are managed at the Swan Lake Research Farm. On‐farm and plot‐scale fields are instrumented with Phenocams to capture continuous photographic records. The CCE at UMRB‐Morris aims to integrate soil, crop, weather data, and image classification to assess benefits and challenges across different management strategies.
5‐Fluorouracil metabolic pathway genes predict recurrence risk following adjuvant S‐1 therapy: Results of an ancillary analysis from a phase III trial of resected biliary tract cancer (JCOG1202A1)
Authors: Mitsunaga Shuichi , Ikeda Masafumi , Nomura Shogo , Morizane Chigusa , Todaka Akiko , Yamamoto Naoto , Kamata Ken , Yanagibashi Hiroo , Mizuno Nobumasa , Kawamoto Yasuyuki , Gotoh Kunihito , Shirakawa Hirofumi , Okano Naohiro , Nomura Tatsuya , Tanaka Kazunari , Takahashi Amane , Yagi Shintaro , Ohta Koji , Takayama Yukiko , Miwa Haruo , Nagano Hiroaki , Kojima Yasushi , Hisano Terumasa , Tahara Munenori , Sakuma Yasunaru , Arai Hiroyuki , Nakamura Ikuo , Katayama Hiroshi , Konishi Masaru , Ueno Makoto ,   Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG‐HBPOG)
Published: September 2024

AbstractBackgroundS‐1, an oral fluoropyrimidine derivative, is standard adjuvant therapy for resected biliary tract cancer (BTC), based on the results of the JCOG1202, a phase III trial evaluating the survival benefit with adjuvant S‐1 following curative resection for BTC compared to surgery alone. This multicenter ancillary study of the JCOG1202 aimed to evaluate the prognostic impact of the 5‐fluorouracil (5‐FU) metabolic pathway genes including thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD).MethodsThe 5‐FU metabolic pathway genes were measured in tumor cells from formalin‐fixed paraffin‐embedded resected specimens from 183 patients (surgery alone: n = 94; adjuvant S‐1: n = 89). We randomly divided them into training (n = 96) and validation sets (n = 87) for evaluating the interaction between gene levels and RFS benefits in the treatment arm.ResultsRFS benefits of adjuvant S‐1 were observed in the low DPD (HR = 0.440 and 0.748, respectively in the training and validation sets) and the low TP groups (HR = 0.709 and 0.602, respectively). Clinicopathological characteristics were well balanced between low and high DPD populations. More advanced stage tumors were observed in high TP populations as compared to those in low TP populations (p = .0332).ConclusionThe results suggest the RFS benefit of adjuvant S‐1 in resected BTC patients with low DPD and low TP gene expressions.
Optimal treatment strategy for patients with pancreatic cancer having positive peritoneal cytology: A nationwide multicenter retrospective cohort study supervised by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Authors: Ariake Kyohei , Mizuma Masamichi , Unno Michiaki , Satoi Sohei , Yamamoto Naoto , Hayashi Masamichi , Kawai Manabu , Akita Hirofumi , Toyoda Eiji , Fujii Tsutomu , Sasaki Masaru , Hakamada Kenichi , Watanabe Jota , Hatano Etsuro , Hidaka Masaaki , Hirano Satoshi , Kurahara Hiroshi , Matsumoto Ippei , Honda Goro , Ogura Toshiro , Nakamura Masafumi , Endo Itaru 
Published: September 2024

AbstractBackgroundThe aim of this study was to determine the optimal treatment for patients with pancreatic cancer (PaCa) having positive peritoneal cytology (PPC).MethodsThis multicenter retrospective study included patients with PPC treated at 78 high‐volume centers between January 2012 and December 2020. Prognoses after resection (S‐group) and initiation of nonsurgical treatment (N‐group) were compared. Prognostic factors for survival in both groups were analyzed. Detailed characteristics of conversion surgery (CS) in the N‐group were evaluated.ResultsIn total, 568 enrolled patients were classified into an S‐group (n = 445) or an N‐group (n = 123). Median survival times (MSTs) were 19.0 months and 19.3 months, respectively, with no significant difference in prognosis (p = .845). The intervenable prognostic factors for survival were adjuvant treatment in the S‐group (p < .001) and CS in the N‐group (p < .001). Following CS, the MST was prolonged to 45.6 months, and peritoneal or liver recurrence decreased considerably. CS can be expected if PPC is diagnosed before neoadjuvant treatment and when combination treatment is initiated.ConclusionSurgical resection may not be beneficial for improving survival when PPC is evident. Chemotherapy aiming for CS may be the optimal treatment for such patients.
Applying multiple‐channel GNR on 4H‐SiC semiconducting material intensifying hydrogen gas sensor performance
Authors: Anvarifard Mohammad K. , Ramezani Zeinab , Ghoreishi S. Amir 
Published: September 2024

AbstractThe graphene nanoribbon field effect transistor abbreviated GNR‐FET is seriously emphasized for the hydrogen gas detection owing to attractive properties induced by the graphene material. For the first time, a multiple‐channel GNR deposited on 4H‐SiC semiconducting material is offered to detect the hydrogen gas. The hydrogen gas by different pressures is released to the multiple‐channel GNR to figure out the sensing power of the proposed sensor. The Pd metal is used as catalytic electrode trapping the hydrogen gas by making dipoles on the gate oxide/electrode interface. A Technology computer‐aided design based model from the non‐equilibrium green function (NEGF) method coupled with the Poisson–Schrodinger equation is used to simulate the electrical manner of the proposed gas sensor by workfunction modulation induced by these dipoles. The channel conduction during sensing hydrogen gas is much enhanced owing to the multiple‐channel GNR configuration. Three sensitivity definitions based on threshold voltage, ON current, and OFF current are presented and applied as benchmarks to evaluate the sensing power of the gas sensor. The results have shown the domination of the multiple‐channel GNR as compared to the single GNR sensor.
An in vitro study of glenoid implant peripheral peg interface mechanics during eccentric loading and lift‐off
Authors: Targosinski Jakub , Kusins Jonathan , Athwal George , Nelson Andrew , Ferreira Louis 
Published: September 2024

AbstractGlenoid implants used in anatomic total shoulder arthroplasties typically incorporate peripheral pegs as a design feature to support eccentric loads. These peripheral pegs and the implant‐cement‐bone interface undergo substantial cyclic tensile‐compressive loads during normal activity. Therefore, these pegs are of interest in translating the micromechanics of local implant fixation failure to the biomechanics of gross anatomic failure of the glenoid implant after total shoulder arthroplasty. This study used an in vitro peg‐cement‐bone construct which incorporated bone tissue acquired from osteoarthritic patients undergoing total shoulder arthroplasty. Strain distributions in the peripheral peg‐cement‐bone interfaces were analyzed under loading conditions emulating glenoid implant edge displacements. It was found that tensile strains in the interfaces were highest near the backside‐peg junction and were greater in magnitude than compressive strains. Notably, strains near the peg's fixation channels were relatively low. These results suggest that cracks may initiate around the peg near the backside and travel downward to cause broader fixation failure.
Overexpression of CGRP receptor attenuates tendon graft degeneration in anterior cruciate ligament reconstruction
Authors: Zhao Xibang , Cai Zhaoji , Luo Ying , Lin Zhousheng , Wang Jiali 
Published: September 2024

AbstractCell apoptosis or necrosis, extracellular matrix loss, and excessive inflammation may induce tendon graft degeneration. The impairment in the regeneration capability of nerve fibers and blood vessels may be the critical cause. Calcitonin gene‐related peptide (CGRP), exhibiting a short half‐life, favors cell proliferation, nerve fiber regeneration and angiogenesis. We aimed to investigate the effects of CGRP receptor‐mediated signaling on tendon graft integrity and study if the modulation pathways are ascribed to cell proliferation, nerve fiber and blood vessel regeneration. A total of three groups in mice with ACL reconstruction were established: the control group (PBS treatment), the adenovirus vectors expressing CGRP receptor (CALCRL) treated group (Adv‐Calcrl treatment), and the adenovirus vectors carrying shRNA targeting Calcrl treated group (Adv‐shCalcrl treatment). The histological assessment indicated the Adv‐Calcrl treatment was favored while the Adv‐shCalcrl significantly impaired tendon graft integrity. TUNEL staining revealed a significant decreased number of apoptotic cells in the Adv‐Calcrl group relative to the control group and the adv‐shCalcrl group. Compared to the control group and the Adv‐shCalcrl group, the Adv‐Calcrl group showed significantly enhanced proliferation of nestin positive cells. Of note, the Adv‐Calcrl treatment significantly increased EMCN expression at the tendon graft relative to the control and the Adv‐shCalcrl groups, which may be ascribed to attenuation of the Hippo signaling pathway. Importantly, the Adv‐Calcrl treatment significantly increased sensory nerve fibers and also PIEZO2 levels. Our results demonstrate the activation of CGRP receptor‐mediated signaling attenuated tendon graft degeneration, which was ascribed to enhanced proliferation of Nestin positive cells, angiogenesis, and nerve fiber outgrowth.
Contaminated well water driving d‐lactic acidosis in child with short bowel syndrome
Authors: Murayi Judy‐April , Flahive Colleen , Mezoff Ethan 
Published: September 2024

Abstractd‐Lactic acidosis is a rare type of lactic acidosis that typically presents in patients with short bowel syndrome (SBS). Clinical features include a high anion‐gap metabolic acidosis and acute onset of neurological impairment. The underlying pathology is thought to be due to altered gut flora and carbohydrate malabsorption in patients with altered gut anatomy. The treatment centers on correcting acid–base derangements, dietary modifications to decrease carbohydrate intake and antibiotics. We present a case of recurrent d‐lactic acidosis in a patient with SBS. In this unique case, we highlight the importance of considering the home environment when developing a treatment plan.