bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerodynamical phenomena in a large top covered wind mill with vertical axis wind turbine
Authors: Baïri Abderrahmane , Crua Cyril , Bauzin Jean-Gabriel , Baïri Iken 
Published: December 2015

Purpose– The purpose of this paper is to examine the aerodynamical and air mass flow phenomena taking place in the channel of a modified version of one of the well-known Sistan wind mills, in order to improve its aerodynamic performance.Design/methodology/approach– The simulations are done by means of the finite volume method associated to the realizable k-ε turbulence model. The computational domain consists in a rotating sub domain including the wind turbine equipped with nine blades and a fixed sub domain including the rest of the computational domain. Both are connected by means of a sliding mesh interface. Calculations are done for 8×105-4×106 Reynolds number range, corresponding to inlet velocities varying from 2 to 10 m s−1.Findings– The velocity fields are presented for the stopped and operating turbine (static and dynamic conditions). A careful examination of the aerodynamic phenomena is performed to detect potential vortices that could develop in the central cavity of the active assembly, and then influence the wind turbine’s operation.Originality/value– The modification proposed in this survey is easy to realize, consisting in covering the top of the entire original assembly that avoids the extraction of a large part of the air mass flow occurring through the open top of the original version. The aerodynamic phenomena occurring across the channel of this large vertical axis wind turbine are substantially different from those of the original version.
‘We needed to change the mission statement of the marriage’: biographical disruptions, appraisals and revisions among couples living with endometriosis
Authors: Hudson Nicky , Culley Lorraine , Law Caroline , Mitchell Helene , Denny Elaine , Raine‐Fenning Nick 
Published: December 2015

AbstractThe concept of biographical disruption has been widely applied in sociological explorations of chronic illness and has been subject to much theoretical scrutiny, reflection and development. However, little attention has been given to the impact of biographical disruption beyond the individual level. This article explores the concept from a dyadic perspective, utilising data from an exploratory, qualitative study (ENDOPART) that investigated the impact of endometriosis on women and their male partners. In total, 22 couples participated in in‐depth, semi‐structured, face‐to‐face interviews. The women and their partners were interviewed separately and, in most cases, simultaneously, by different interviewers. Data analysis was informed by an interpretivist relational approach, foregrounding the meanings participants applied to their experiences, treating interviews as accounts, and exploring partners’ accounts in relation to one another. Two analytic approaches generated several themes for exploration in the context of the concept of biographical disruption: sex and intimacy; planning for and having children; working lives and social lives. The article argues that biographical disruptions are social and inter‐relational processes and discusses how couples living with endometriosis negotiated these disruptions, how they were appraised and how lives and expectations were revised as a result.
Effect of Span 60 on the Microstructure, Crystallization Kinetics, and Mechanical Properties of Stearic Acid Oleogels: An In‐Depth Analysis
Authors: Uvanesh K. , Sagiri S. S. , Senthilguru K. , Pramanik K. , Banerjee I. , Anis Arfat , Al‐Zahrani S. M. , Pal Kunal 
Published: December 2015

AbstractModulation of crystallization of stearic acid and its derivatives is important for tuning the properties of stearate oleogels. The present study delineates the crystallization of stearic acid in stearate oleogels in the presence of Span 60. Microarchitecture analysis revealed that stearic acid crystals in the oleogels changed its shape from plate‐like structure to a branched architecture in the presence of Span 60. Consequently, a significant variation in the mobility of the solute molecules inside the oleogel (Fluorescence recovery after photobleaching studies, FRAP analysis) was observed. Thermal analysis (gelation kinetics and DSC) revealed shortening of nucleation induction time and secondary crystallization with an increase in the Span 60 concentration. Furthermore, isosolid diagram suggested better physical stability of the formulations at higher proportions of Span 60. XRD analysis indicated that there was a decrease in the crystal size and the crystallinity of the stearic acid crystals with an increase in Span 60 concentration in the Span 60 containing oleogels. However, crystal growth orientation was unidirectional and found unaltered with Span 60 concentration (Avarmi analysis using DSC data). The mechanical study indicated a composition‐dependent variation in the viscoelastic properties (instantaneous [τ1], intermediate [τ2], and delayed [τ3] relaxation times) of the formulations. In conclusion, Span 60 can be used to alter the kinetics of the crystallization, crystal habit and crystal structure of stearic acid. This study provides a number of clues that could be used further for developing oleogel based formulation.
Expression and clinical significance of A‐kinase anchor protein 4 in lung adenocarcinoma tissue
Authors: Li Hong‐Mei , Guo Kang , Yu Xiao‐Yun , Yu Zhuang , Xu Ping 
Published: December 2015

AbstractBackgroundThe A‐kinase anchor proteins (AKAP) are a growing family of scaffolding proteins involved in the occurrence, proliferation, and metastasis of tumors by controlling intracellular signals. In this study, the expression and significance of AKAP4 were analyzed in patients with lung adenocarcinoma and adjacent non‐cancerous tissues.MethodsUsing reverse transcriptase‐polymerase chain reaction and Western blot, AKAP4 messenger ribonucleic acid (mRNA) and protein expression levels were measured in 108 cases of lung adenocarcinoma and adjacent non‐cancerous tissues.ResultsAKAP4 mRNA and protein were expressed in lung adenocarcinoma tissues, but not in adjacent non‐cancerous tissues. The expression of AKAP4 mRNA and protein was closely associated with lymphatic metastasis (P < 0.05), but had no relationship with stage, differentiation degree, gender, age or smoking (P > 0.05). AKAP4 expression had an adverse effect on the overall survival rate (P < 0.05).ConclusionThe expression of AKAP4 was high in lung adenocarcinoma tissue, which may be closely related to the lymphatic metastasis of lung adenocarcinoma. AKAP4 may be a novel lung adenocarcinoma molecule marker and a predictor of poor prognosis.
Hypofractionated radiotherapy for medically inoperable stage I non‐small cell lung cancer
Authors: Jiang Wei , Wang Jian‐Yang , Wang Jing‐Bo , Liang Jun , Hui Zhou‐Guang , Wang Xiao‐Zhen , Zhou Zong‐Mei , Wang Lu‐Hua 
Published: December 2015

AbstractBackgroundTo investigate the clinical outcomes and toxicity of hypofractionated radiotherapy for medically inoperable stage I non‐small cell lung cancer (NSCLC).MethodsPatients treated with radiotherapy at a dose of 4–6 Gy per fraction using fixed‐field intensity modulated radiotherapy (IMRT) or volumetric‐modulated arc therapy (VMAT) at our hospital from June 2005 to December 2013 were analyzed. The total prescription doses ranged from 50–78 Gy with 4–6 Gy per fraction. The median follow‐up period was 24 months.ResultsA total of 65 patients with stage I NSCLC were analyzed, including 43 primary NSCLC patients and 22 patients with recurrent or second primary NSCLC. An objective response (complete or partial response) was achieved at six months in 84.6% of patients. The three‐year local control rate was 90.8%. Kaplan–Meier estimates of local failure‐free, progression‐free, overall, and cancer‐specific survival rates at three years were 90.3%, 64.3%, 68.9%, and 88.8%, respectively. The rate of symptomatic radiation pneumonitis was 16.9%, and no grade 4–5 toxicity was observed.ConclusionFavorable local control and outcome was achieved with hypofractionated radiotherapy in patients with inoperable stage I NSCLC with acceptable toxicity. The most common schedule of 6 Gy × 12 fractions may be a promising regimen, and a prospective study is in process.
Dutch healthcare professionals inadequately perceived if three‐ and four‐year‐old preschool children were overweight
Authors: Bocca Gianni , Corpeleijn Eva , Broens Jasper , Stolk Ronald P. , Sauer Pieter J. 
Published: December 2015

AbstractAimWe studied whether healthcare professionals adequately perceived if preschool children were overweight and whether this was influenced by their own body mass index (BMI).MethodsWe sent 716 Dutch healthcare professionals questionnaires containing seven pictures and seven sketches of three‐ and four‐year‐old children showing body weights from underweight to morbidly obese. The professionals rated the pictures on a five‐point scale from too heavy to too light and chose the sketch that they felt best depicted the child's body shape. They also reported their own height and weight and their BMI was calculated.ResultsOf the 716 questionnaires, 346 (48.3%) were returned with complete information and analysed. Healthcare professionals mostly chose sketches that showed children as being lighter than they really were. Depending on their own BMI group, the overweight child was perceived as having a normal weight by 74–79% of the healthcare professionals. The obese children were rated correctly by 44–52% of the professionals, but 14–15% said their weight was normal. The morbidly obese child was adequately assessed by 93–98% of the professionals.ConclusionHealthcare professionals inadequately perceived whether three‐ and four‐year‐old children were overweight and this may have hindered early interventions, leading to overweight children becoming overweight adolescents.
Optimising musculoskeletal care for patients with haemophilia
Authors: Carcao Manuel , Hilliard Pamela , Escobar Miguel A. , Solimeno Luigi , Mahlangu Johnny , Santagostino Elena 
Published: December 2015

AbstractDespite recent improvements in the quality of care and treatment outcomes for haemophilia, joint disease remains a major concern for patients with and without inhibitors. Most bleeding episodes occur in the musculoskeletal system, and recurrent bleeding may result in progressive joint damage, leading to haemophilic arthropathy. Consequently, early identification and management of musculoskeletal bleeding episodes are important to prevent crippling deformities and dysfunction. Management strategies should aim at optimising joint function by reducing the frequency of, and preventing, joint bleeds. Although prophylactic factor replacement is proven to be effective in reducing bleeding frequency into joints and preserving musculoskeletal function in patients without inhibitors, the role for prophylaxis (with bypassing agents) in patients with inhibitors remains unclear. The available bypassing agents, activated prothrombin complex concentrate and recombinant activated factor VII (rFVIIa), are currently the standard of care for acute bleeding episodes in patients with high‐titre inhibitors. These agents also prevent bleeding during elective orthopaedic surgery (EOS) in this patient population. This review discusses published data and uses illustrative cases to describe effective strategies for assessing joint health and maintaining optimal musculoskeletal care, focusing on the use of rFVIIa for haemostatic control in haemarthroses and when EOS is required in patients with inhibitors.
Cooperative advertising in a capacitated manufacturer–retailer supply chain: a game‐theoretic approach
Authors: Ahmadi‐Javid Amir , Hoseinpour Pooya 
Published: December 2015

AbstractTo achieve a more realistic understanding of how the supply chain's components interact, it is helpful to consider the operational limitations of the underlying supply chain while analyzing cooperative advertising. This paper studies cooperative advertising in a manufacturer–retailer supply chain under the practical operational assumption that the manufacturer's production capacity is limited. The retailer advertises locally, and the manufacturer advertises in national media and supports part of the retailer's promotional costs. Equilibria are determined under two different scenarios. In the first scenario, both retailer and manufacturer move simultaneously, while in the second scenario, they move sequentially, with the manufacturer being the leader. The sales function is a bivariate version of the diminishing returns response function. When the production capacity is unlimited, several important properties can be proven, which cannot be shown analytically for the existing sales functions. Considering the production‐capacity constraint leads to new managerial insights into cooperative advertising. For example, only if the production capacity is large enough, both manufacturer and retailer are better off under the second scenario than the first scenario. In other words, the sequential move is not necessarily Pareto‐improving when the production capacity is limited. It is also observed that, under the first scenario, there are multiple equilibria whenever the production capacity is not too high. Under the second scenario, the manufacturer supports the retailer only when the retailer's margin is relatively small compared to the manufacturer's margin and production capacity.
Short‐term Modulation of Domestic Pigeon (Columbia livia L.) Behaviour Induced by Intraventricular Administration of ACTH
Authors: DEVICHE PIERRE , DELIUS JUAN D. 
Published: December 2015

AbstractThe behavioural responses induced in adult domestic pigeons by intraventricular injections of 0 to 6 IU of ACTH 1–39 are reported. The frequency of 10 different behaviour patterns was recorded for 90 min after administration of the peptide. The effect that was induced was complex, the frequency of some patterns increasing (yawning, headshaking, body shaking, wing‐flapping), of some others decreasing (feeding, one‐wing stretching, eye closing) or remaining unchanged (preening). The frequency of several patterns was maximal during the first 30 min following the injections but this was shown in some cases to be independent on the hormone administration.
Male Relationships and Infant Deaths in Red Howler Monkeys (Alouatta seniculus)
Authors: SEKULIC RANKA 
Published: December 2015

AbstractFor decades howler monkeys were considered to be among the most peaceful animals. Recent investigators, however, have noted that, although male aggression is rare, it may be extremely severe; the criteria used to quantify howler relationships should therefore be different from those used for other primates. This paper describes the pattern of male relationships in the red howler monkey Alouatta seniculus, and examines its effect on reproductive success within the troop and the ability of troop males to resist intrusion by competing males. 4 of the 8 infants born during the study period were killed or disappeared when change occurred in relative status between two adult males.
Postpartum Sexual Functioning and Method of Delivery: Summary of the Evidence
Authors: Hicks Tara L. , Goodall Susan Forester , Quattrone Evelyn M. , Lydon‐Rochelle Mona T. 
Published: December 2015

ABSTRACTShort‐term postpartum sexual problems are highly prevalent, ranging from 22% to 86%; however, there are few studies that address how mode of delivery affects sexual functioning after childbirth. The objective of this study was to perform a systematic review of the literature on selected postpartum sexual function outcomes as affected by cesarean, assisted vaginal, and spontaneous vaginal delivery. We searched PubMed, CINAHL, and Cochrane databases from January 1990 to September 2003 and focused on mode of delivery and the most commonly reported sexual health outcomes, which included perineal pain, dyspareunia, resumption of intercourse, and self‐reported perception of sexual health/sexual problems. The studies all showed increased risks of delay in resumption of intercourse, dyspareunia, sexual problems, or perineal pain associated with assisted vaginal delivery. Some studies showed no differences in sexual functioning between women with cesarean delivery and those with spontaneous vaginal delivery, whereas others reported less dyspareunia for women with cesarean delivery. A systematic review of the literature suggests an association between assisted vaginal delivery and some degree of sexual dysfunction. Reported associations between cesarean delivery and sexual dysfunction were inconsistent. Continued research is necessary to identify modifiable risk factors for sexual problems related to method of delivery.
The Role of Drugs in Adolescent Suicide Attempts
Authors: McKenry Patrick C. , Tishler Carl L. , Kelley Coleen 
Published: December 2015

AbstractDrug histories of 46 adolescent suicide attempters and their parents are described. In addition, these attempters and their parents are compared with a group of non‐attempters and their parents on selected measures of drug use. Findings indicate that adolescent drug use is closely related to and perhaps symptomatic of suicidal behaviors and overall pathology. The relationship between adolescent suicidal behaviors and parental drug use is unclear because of the discrepancy between parent‐adolescent responses.
Genomic prediction of growth in pigs based on a model including additive and dominance effects
Authors: Lopes M.S. , Bastiaansen J.W.M. , Janss L. , Knol E.F. , Bovenhuis H. 
Published: December 2015

SummaryIndependent of whether prediction is based on pedigree or genomic information, the focus of animal breeders has been on additive genetic effects or ‘breeding values’. However, when predicting phenotypes rather than breeding values of an animal, models that account for both additive and dominance effects might be more accurate. Our aim with this study was to compare the accuracy of predicting phenotypes using a model that accounts for only additive effects (MA) and a model that accounts for both additive and dominance effects simultaneously (MAD). Lifetime daily gain (DG) was evaluated in three pig populations (1424 Pietrain, 2023 Landrace, and 2157 Large White). Animals were genotyped using the Illumina SNP60K Beadchip and assigned to either a training data set to estimate the genetic parameters and SNP effects, or to a validation data set to assess the prediction accuracy. Models MA and MAD applied random regression on SNP genotypes and were implemented in the program Bayz. The additive heritability of DG across the three populations and the two models was very similar at approximately 0.26. The proportion of phenotypic variance explained by dominance effects ranged from 0.04 (Large White) to 0.11 (Pietrain), indicating that importance of dominance might be breed‐specific. Prediction accuracies were higher when predicting phenotypes using total genetic values (sum of breeding values and dominance deviations) from the MAD model compared to using breeding values from both MA and MAD models. The highest increase in accuracy (from 0.195 to 0.222) was observed in the Pietrain, and the lowest in Large White (from 0.354 to 0.359). Predicting phenotypes using total genetic values instead of breeding values in purebred data improved prediction accuracy and reduced the bias of genomic predictions. Additional benefit of the method is expected when applied to predict crossbred phenotypes, where dominance levels are expected to be higher.
Distributed Cogeneration of Power and Heat within an Energy Management Strategy for Mitigating Fossil Fuel Consumption
Authors: Kikuchi Yasunori , Kanematsu Yuichiro , Sato Ryuichi , Nakagaki Takao 
Published: December 2015

SummaryDistributed energy sources, such as self‐power generation, steam boilers, and combined heat and power production (CHP), are operated to manage the supply of energy by optimizing the costs of meeting the demand for electricity and heat. This article was written in conjunction with reports by the United Nations Environment Program's International Resource Panel that quantifies and compares the environmental and natural resource impacts and benefits of using demand‐side efficient technologies for greenhouse gas mitigation scenarios from now until 2050. In this article, we examine the potential of using distributed energy sources in future energy systems. First, we reviewed the existing research into several energy technologies, especially into cogeneration systems for CHP, using a bibliometric analysis. The current energy supply/demand in the demand‐side sectors in Japan is also reviewed using available statistical data, and an investigation into the energy requirements of industrial manufacturers was performed. After systematizing the results of our review on progress in current research, a scenario analysis was conducted on the potential of distributed energy sources to clarify the contribution of the various technology options. A mismatch between the quality of energy produced, especially heat, or any benefits arising from scale from other energy technologies, can decrease the incentive to implement distributed energy technologies. As a requirement of a regional energy system design and management, distributed energy sources should be considered so that the appropriate technology options can be adopted for the desired energy supply in the demand‐side sector. The possibility exists to replace conventional single‐generation technologies, such as boilers or power generators, with multigeneration technologies. A change in the grid power mix is one of the most sensitive parameters affecting the performance of cogeneration technologies.
Assessment of the Hong Kong Liver Cancer Staging System in Europe
Authors: Kolly Philippe , Reeves Helen , Sangro Bruno , Knöpfli Marina , Candinas Daniel , Dufour Jean‐François 
Published: December 2015

AbstractBackground & AimsEuropean and American guidelines have endorsed the Barcelona Clinic Liver Cancer (BCLC) staging system. The aim of this study was to assess the performance of the recently developed Hong Kong Liver Cancer (HKLC) classification as a staging system for hepatocellular carcinoma (HCC) in Europe.MethodsWe used a pooled set of 1693 HCC patients combining three prospective European cohorts. Discrimination ability between the nine substages and five stages of the HKLC classification system was assessed. To evaluate the predictive power of the HKLC and BCLC staging systems on overall survival, Nagelkerke pseudo R2, Bayesian Information Criterion and Harrell's concordance index were calculated. The number of patients who would benefit from a curative therapy was assessed for both staging systems.ResultsThe HKLC classification in nine substages shows suboptimal discrimination between the staging groups. The classification in five stages shows better discrimination between groups. However, the BCLC classification performs better than the HKLC classification in the ability to predict overall survival (OS). The HKLC treatment algorithm tags significantly more patients to curative therapy than the BCLC.ConclusionsThe BCLC staging system performs better for European patients than the HKLC staging system in predicting OS. Twice more patients are eligible for a curative therapy with the HKLC algorithm; whether this translates in survival benefit remains to be investigated.