bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theory-related translation research. Some thoughts on methodology
Authors: Gerzymisch-Arbogast Heidrun 
Published: February 2017

The article illustrates some methodological principles for translation research and for writing theory-related research papers. A number of postulates are formulated with respect to basic structural dimensions of organizing research papers (working hypothesis, ‘state of the art’ in research, solution proposal and validity test). Examples for norm-compliant behavior are given. Since the problem of writing the ‘state of the art’ of research seems to be one of the major problems facing young scholars, particular emphasis is given to this aspect.
Enhanced Electrochemical Properties of Li3VO4 with Controlled Oxygen Vacancies as Li‐Ion Battery Anode
Authors: Wang Kan , Zhang Changkun , Fu Haoyu , Liu Chaofeng , Li Zhuoyu , Ma Wenda , Lu Xianmao , Cao Guozhong 
Published: February 2017

AbstractLi3VO4, as a promising intercalation‐type anode material for lithium‐ion batteries, features a desired discharge potential (ca. 0.5–1.0 V vs. Li/Li+) and a good theoretical storage capacity (590 mAh g−1 with three Li+ inserted). However, the poor electrical conductivity of Li3VO4 hinders its practical application. In the present work, various amounts of oxygen vacancies were introduced in Li3VO4 through annealing in hydrogen to improve its conductivity. To elucidate the influence of oxygen vacancies on the electrochemical performances of Li3VO4, the surface energy of the resulting material was measured with an inverse gas chromatography method. It was found that Li3VO4 annealed in pure hydrogen at 400 °C for 15 min exhibited a much higher surface energy (60.7 mJ m−2) than pristine Li3VO4 (50.6 mJ m−2). The increased surface energy would lower the activation energy of phase transformation during the charge–discharge process, leading to improved electrochemical properties. As a result, the oxygen‐deficient Li3VO4 achieved a significantly improved specific capacity of 495 mAh g−1 at 0.1 Ag−1 (381 mAh g−1 for pristine Li3VO4) and retains 165 mAh g−1 when the current density increases to 8 Ag−1.
Acacia caven nurses endemic sclerophyllous trees along a successional pathway from silvopastoral savanna to forest
Authors: Root‐Bernstein Meredith , Valenzuela Rafael , Huerta Margarita , Armesto Juan , Jaksic Fabián 
Published: February 2017

AbstractThe successional pathways linking the Acacia caven‐dominated savanna habitat “espinal” and the closed sclerophyllous forest of central Chile have long been debated. Previously, espinal was considered an invasive degradation of closed forest that tended toward desertification, could not be restored to forest, and had little ecological value. Recent GIS (Geographical Information System) research on land‐use change has, however, detected apparent regeneration of sclerophyllous forest from espinal. This suggests that there is a successional path linking espinal and sclerophyllous forest. Here, we used surveys of transects in espinals and espinal–sclerophyllous forest transitions to ask whether (1) A. caven is an invasive species or a pioneer species, (2) forest regenerates by sclerophyllous trees “filling in” spaces between A. caven individuals, and then shading them out (plant–plant competition), or (3) forest regenerates by plant–plant facilitation between A. caven and other species, and (4) how current and historical management and condition affect these potential successional mechanisms. We find that A. caven establishes primarily in full sunlight and is unlikely to degrade forests via invasion. We also find, for the first time, evidence that A. caven is a nurse tree to several sclerophyllous forest tree‐beneficiary species. Measurements of the under‐canopy microhabitat of A. caven, compared to Lithraea caustica, another possible nurse species, suggest that it provides a balance between shade and soil moisture retention, making it a regeneration site not only for directed bird‐dispersed seeds but also for undirected wind‐dispersed ones. Conservation and restoration of espinals, especially in drier areas, could provide capacity for future dynamic successional pathways in central Chile.
Inhibition of microRNA‐153 protects neurons against ischemia/reperfusion injury in an oxygen–glucose deprivation and reoxygenation cellular model by regulating Nrf2/HO‐1 signaling
Authors: Ji Qiong , Gao Jianbo , Zheng Yan , Liu Xueli , Zhou Qiangqiang , Shi Canxia , Yao Meng , Chen Xia 
Published: February 2017

AbstractMicroRNAs are emerging as critical regulators in cerebral ischemia/reperfusion injury; however, their exact roles remain poorly understood. miR‐153 is reported to be a neuron‐related miRNA involved in neuroprotection. In this study, we aimed to investigate the precise role of miR‐153 in regulating neuron survival during cerebral ischemia/reperfusion injury using an oxygen–glucose deprivation and reoxygenation (OGD/R) cellular model. We found that miR‐153 was significantly upregulated in neurons subjected to OGD/R treatment. Inhibition of miR‐153 significantly attenuated OGD/R‐induced injury and oxidative stress in neurons. Nuclear factor erythroid 2‐related factor 2 (Nrf2) was identified as a target gene of miR‐153. Inhibition of miR‐153 significantly promoted the expression of Nrf2 and heme oxygenase‐1 (HO‐1). However, silencing of Nrf2 significantly blocked the protective effects of miR‐153 inhibition. Our study indicates that the inhibition of miR‐153 protects neurons against OGD/R‐induced injury by regulating Nrf2/HO‐1 signaling and suggests a potential therapeutic target for cerebral ischemia/reperfusion injury.
Global assessment of cancer incidence and survival in adolescents and young adults
Authors: Bleyer Archie , Ferrari Andrea , Whelan Jeremy , Barr Ronald D. 
Published: February 2017

AbstractIn high‐income countries, cancer remains the commonest cause of disease‐related death in adolescents and young adults (AYAs) despite survival improvements. With more than 1,000,000 new diagnoses of cancer in AYAs annually worldwide, and their number of life‐years affected by cancer being greatest of all ages, the global burden of cancer in AYAs exceeds that in all other ages. In low‐ and middle‐income countries, where the great majority of the world's 3 billion AYAs reside, the needs of those with cancer have been identified and demand attention. Unique to the age group but universal, the psychosocial challenges they face are the utmost across life's spectrum.This lead‐off article of a new series in Pediatric Blood and Cancer on AYA oncology attempts to assess the global status of this emerging discipline. The review includes the changing incidence and survival of the common cancers in AYAs—there is no other age group with a similar array of malignancies—and the specific challenges to quality and quantity of life that compromise their lives.
Selective Expansion of Skeletal Muscle Stem Cells from Bulk Muscle Cells in Soft Three-Dimensional Fibrin Gel
Authors: Zhu Pei , Zhou Yalu , Wu Furen , Hong Yuanfan , Wang Xin , Shekhawat Gajendra , Mosenson Jeffrey , Wu Wen-Shu 
Published: February 2017

Abstract
Muscle stem cells (MuSCs) exhibit robust myogenic potential in vivo, thus providing a promising curative treatment for muscle disorders. Ex vivo expansion of adult MuSCs is highly desired to achieve a therapeutic cell dose because of their scarcity in limited muscle biopsies. Sorting of pure MuSCs is generally required for all the current culture systems. Here we developed a soft three-dimensional (3D) salmon fibrin gel culture system that can selectively expand mouse MuSCs from bulk skeletal muscle preparations without cell sorting and faithfully maintain their regenerative capacity in culture. Our study established a novel platform for convenient ex vivo expansion of MuSCs, thus greatly advancing stem cell-based therapies for various muscle disorders.
Insight into the bacterial diversity of fermentation woad dye vats as revealed by PCR-DGGE and pyrosequencing
Authors: Milanović Vesna , Osimani Andrea , Taccari Manuela , Garofalo Cristiana , Butta Alessandro , Clementi Francesca , Aquilanti Lucia 
Published: February 2017

Abstract
The bacterial diversity in fermenting dye vats with woad (Isatis tinctoria L.) prepared and maintained in a functional state for approximately 12 months was examined using a combination of culture-dependent and -independent PCR-DGGE analyses and next-generation sequencing of 16S rRNA amplicons. An extremely complex ecosystem including taxa potentially contributing to both indigo reduction and formation, as well as indigo degradation was found. PCR-DGGE analyses revealed the presence of Paenibacillus lactis, Sporosarcina koreensis, Bacillus licheniformis, and Bacillus thermoamylovorans, while Bacillus thermolactis, Bacillus pumilus and Bacillus megaterium were also identified but with sequence identities lower than 97%. Dominant operational taxonomic units (OTUs) identified by pyrosequencing included Clostridium ultunense, Tissierella spp., Alcaligenes faecalis, Erysipelothrix spp., Enterococcus spp., Virgibacillus spp. and Virgibacillus panthothenicus, while sub-dominant OTUs included clostridia, alkaliphiles, halophiles, bacilli, moderately thermophilic bacteria, lactic acid bacteria, Enterobacteriaceae, aerobes, and even photosynthetic bacteria. Based on the current knowledge of indigo-reducing bacteria, it is considered that indigo-reducing bacteria constituted only a small fraction in the unique microcosm detected in the natural indigo dye vats.
Safe Energy Source in Battery‐operated Toys for Children
Authors: Rossi Alfredo , Vignola Silvia , Nason Francesca , Boschetti Federica , Bramerio Manuela , Bailini Alessandro , Pinarello Giordano 
Published: February 2017

ABSTRACTObjectives:Serious and even fatal consequences of disk batteries ingestion in children are well known. Among other applications, disk batteries are used to power small toys, from which they can be unexpectedly extracted and swallowed.Methods:We tested a new cell intended for little toys (green cell [GC]), after 6 and 12 hours of in vitro close contact with esophageal swine mucosa. The GC was compared with lithium and silver button batteries under the same experimental conditions.Results:Tissues in contact with the GC did not show pH variations nor histological alterations after 6 and 12 hours. In such conditions, statistically significant differences were found between the GC and the lithium and silver batteries.Conclusions:So far, multidisciplinary medical effort has been driven to both emergency approach and subsequent operative strategies in children with ingested batteries. Our trial demonstrates the possibility to primarily prevent battery‐induced damages by designing new‐generation safe cells with no tissue toxicity to power little toys intended for children.
Reconnecting with place through events
Authors: Coghlan Alexandra , Sparks Bev , Liu Wei , Winlaw Mike 
Published: February 2017

Purpose
Whilst academic research can capture an existing sense of place, the act of placemaking through strategies such as events depends upon the attitudes and actions of precinct managers and event organisations. The purpose of this paper is to investigate the collaborative research process between researchers and a precinct manager that highlighted an event’s ability to contribute to placemaking within that precinct.

Design/methodology/approach
Using the results of this event experience study, informal interviews with the SPA research partners, secondary data and a longitudinal, reflective account of the research collaboration, the research process itself was investigated to see how it assisted in the (re)design of the event within the precinct manager’s placemaking strategy to encourage a family-friendly, beach-centred culture within the precinct.

Findings
It is proposed that the research results combined with a collaborative research process itself facilitated a shift from the business imperative on the event’s economic performance indicators to a broader discussion of the event’s role in shaping local’s (and visitor’s) perceptions of place, and allowed a broader discussion of the role of events in driving a “liveability” and/or placemaking agenda, complementing the economic impact agenda, for the precinct manager.

Practical implications
The paper suggests how and why it is important for academics to work collaboratively with precinct managers to translate the concept of placemaking into the actual design of events within a place. To do so requires the researchers to bridge the gap between theory and practice. For the concept to be translated into action, greater attention was drawn to the placemaking role of events, positioning it along economic impact measures as a valuable outcome of events.

Originality/value
Few co-authored studies, representing both researchers and practitioners exist within the events sector, and this study contributes towards understanding process of research impact, by considering the forces capable of delivering a placemaking agenda through a precinct’s event portfolio.
Leadership and dynamic capabilities: the role of HR systems
Authors: Lopez-Cabrales Alvaro , Bornay-Barrachina Mar , Diaz-Fernandez Mirta 
Published: February 2017

PurposeThe purpose of this paper is to analyze the antecedents of the development of dynamic capabilities from an HRM perspective, considering the leading role of leadership styles and their potential impact on the orientation of HR systems and a firm’s capabilities.Design/methodology/approachThe authors designed an empirical study of a sample of 107 Spanish industrial firms, asking HR, production and marketing managers to assess the CEO’s leadership styles, the system of HRM practices applied in their organizations and dynamic capabilities. They applied multiple regressions and mediation analysis.FindingsThe authors’ results suggest that both transactional and transformational leadership styles are positively associated with dynamic capabilities (sensing, seizing and reconfiguration), directly and indirectly, through their effects on HR systems.Research limitations/implicationsThis paper approaches dynamic capabilities by using cross-sectional data. A longitudinal analysis would enrich this study. Also, the data aggregation in this paper does not allow to check different HR orientations from different departments. Finally, other HRM practices and strategic orientations could be assessed.Practical implicationsThis paper highlights the need to develop CEOs who are able to combine leadership behaviors in such a way that they promote HR systems (skill-based development vs job-based development) and to use them as mediating mechanisms and in order to generate greater dynamic capabilities in the organization.Originality/valueThe authors are proposing that HRM can be applied to leverage a firm’s competitive advantage, as HR systems mediate for obtaining different dynamic capabilities. Second, it could be concluded that any CEO should combine or display traits of both forms of leadership styles (transformational and transactional) in order to develop the full range of dynamic capabilities. Finally, this paper can provide some insights into the way dynamic capabilities can be measured and approached, through HRM microfoundations.
The gendered impact of the National Pension Scheme on late-life economic well-being: evidence from the Korean retirement and income study
Authors: Park Seung-Min 
Published: February 2017

PurposeThe purpose of this paper is to analyse the effect of the National Pension Scheme (NPS) on the economic well-being of older people in South Korea.Design/methodology/approachIt analyses older people aged 60 and over sampled from the third wave of the Korean retirement and income study.FindingsThe analysis shows a gendered effect. The NPS is positively associated with the economic well-being of only older men. This gendered impact is probably attributable to the inherent patriarchal structure of the NPS that is based on the strong male bread-winner model.Originality/valueThe results suggest that promoting the female labour market participation, and also reforming the gender structure of the NPS and South Korean labour market, can be a potential policy option to amend gendered economic well-being in later life.
Festivals as strategic tools: exploring the Dubai Lynx International Festival of Creativity
Authors: Turnbull Sarah 
Published: February 2017

Purpose
This paper aims to provide insight into the use of festivals as a strategy to position cities as creative hubs.

Design/methodology/approach
This paper has been prepared by an independent author who provides their views and personal experiences of festivals.

Findings
Festivals are an effective strategic tool for countries to use to engage business audiences and associate themselves with values such as creativity.

Originality/value
This paper shares highlights from the 2016 Dubai Lynx International Festival of Creativity. Three presentations have been chosen for review, and two of the developmental programmes are discussed. While these provide only a brief insight into the festival, they reflect the quality of speakers and the unique opportunities for professional development offered at this annual Dubai event.
Buyer and business partner relationship supporting purchasing performance
Authors: Zanardi Mylène 
Published: February 2017

Purpose
In purchasing field, the author would like to demonstrate that purchasing performance can be improved by something else than hard skills. The soft skills have at present an important role to reach the objectives as a buyer, and more focus should be on that aspect of skills. The author proved, by facts and figures, that the soft skills are not used enough and can really improve purchasing performance.

Design/methodology/approach
The methodology used was to interview professional people, manager, directors and buyer in purchasing function to prove the link between performance and soft skills. Indeed, the soft skills are linked to the personality and relationship build between the buyer and the business partner. The author investigated to see what is currently the relation between buyer function and business partner, based on their soft skills.

Findings
The author demonstrated through his interview, reading and analysis that there is a real link between the soft skills – relationship build between buyer and business partner – and purchasing performance.

Originality/value
The value of this paper is that he add a new skill to use to improve the purchasing performance. Indeed, instead of focusing only on saving or on hard skills, a focus can be used on the soft skills which will really improve the relationship and the performance-results in the purchasing function. The main aspect focusing on soft skill will be to act and react differently than we use to, started by listening to the business partner first, listening to their needs, understand their world, their job and their issues. The main change will be to listen before doing anything else. It is necessary to be in an active listening posture with them to be able then to give them answer and improve the own purchasing performance.
How purchasing became a strategic function: from purchasing to external resources management
Authors: Poissonnier Hugues 
Published: February 2017

Purpose
This paper aims to show the most important evolutions of the purchasing function.

Design/methodology/approach
This paper is a historical approach.

Findings
Purchasing is becoming more and more strategic.

Research limitations/implications
New skills are required for buyers.

Originality/value
This paper aims at explaining the evolution of purchasing which is the most evolving function in companies today. By becoming more and more strategic, purchasing contributes to the evolution of all the company.
Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis
Authors: Li Ao , Fan Song , Xu Yuchen , Meng Jialin , Shen Xufeng , Mao Jun , Zhang Li , Zhang Xiansheng , Moeckel Gilbert , Wu Dianqing , Wu Guanqing , Liang Chaozhao 
Published: February 2017

AbstractAlthough translational research into autosomal dominant polycystic kidney disease (ADPKD) and its pathogenesis has made considerable progress, there is presently lack of standardized animal model for preclinical trials. In this study, we developed an orthologous mouse model of human ADPKD by cross‐mating Pkd2 conditional‐knockout mice (Pkd2f3) to Cre transgenic mice in which Cre is driven by a spectrum of kidney‐related promoters. By systematically characterizing the mouse model, we found that Pkd2f3/f3 mice with a Cre transgene driven by the mouse villin‐1 promoter (Vil‐Cre;Pkd2f3/f3) develop overt cysts in the kidney, liver and pancreas and die of end‐stage renal disease (ESRD) at 4–6 months of age. To determine whether these Vil‐Cre;Pkd2f3/f3 mice were suitable for preclinical trials, we treated the mice with the high‐dose mammalian target of rapamycin (mTOR) inhibitor rapamycin. High‐dose rapamycin significantly increased the lifespan, lowered the cystic index and kidney/body weight ratio and improved renal function in Vil‐Cre;Pkd2f3/f3 mice in a time‐ and dose‐dependent manner. In addition, we further found that rapamycin arrested aberrant epithelial‐cell proliferation in the ADPKD kidney by down‐regulating the cell‐cycle‐associated cyclin‐dependent kinase 1 (CDK1) and cyclins, namely cyclin A, cyclin B, cyclin D1 and cyclin E, demonstrating a direct link between mTOR signalling changes and the polycystin‐2 dysfunction in cystogenesis. Our newly developed ADPKD model provides a practical platform for translating in vivo preclinical results into ADPKD therapies. The newly defined molecular mechanism by which rapamycin suppresses proliferation via inhibiting abnormally elevated CDK1 and cyclins offers clues to new molecular targets for ADPKD treatment.
Nandrolone decanoate interferes with testosterone biosynthesis altering blood–testis barrier components
Authors: Barone Rosario , Pitruzzella Alessandro , Marino Gammazza Antonella , Rappa Francesca , Salerno Monica , Barone Fulvio , Sangiorgi Claudia , D'Amico Daniela , Locorotondo Nicola , Di Gaudio Francesca , Cipolloni Luigi , Di Felice Valentina , Schiavone Stefania , Rapisarda Venerando , Sani Gabriele , Tambo Amos , Cappello Francesco , Turillazzi Emanuela , Pomara Cristoforo 
Published: February 2017

AbstractThe aim of this study was to investigate whether nandrolone decanoate (ND) use affects testosterone production and testicular morphology in a model of trained and sedentary mice. A group of mice underwent endurance training while another set led a sedentary lifestyle and were freely mobile within cages. All experimental groups were treated with either ND or peanut oil at different doses for 6 weeks. Testosterone serum levels were measured via liquid chromatography–mass spectrometry. Western blot analysis and quantitative real‐time PCR were utilized to determine gene and protein expression levels of the primary enzymes implicated in testosterone biosynthesis and gene expression levels of the blood–testis barrier (BTB) components. Immunohistochemistry and immunofluorescence were conducted for testicular morphological evaluation. The study demonstrated that moderate to high doses of ND induced a diminished serum testosterone level and altered the expression level of the key steroidogenic enzymes involved in testosterone biosynthesis. At the morphological level, ND induced degradation of the BTB by targeting the tight junction protein‐1 (TJP1). ND stimulation deregulated metalloproteinase‐9, metalloproteinase‐2 (MMP‐2) and the tissue inhibitor of MMP‐2. Moreover, ND administration resulted in a mislocalization of mucin‐1. In conclusion, ND abuse induces a decline in testosterone production that is unable to regulate the internalization and redistribution of TJP1 and may induce the deregulation of other BTB constituents via the inhibition of MMP‐2. ND may well be considered as both a potential inducer of male infertility and a potential risk factor to a low endogenous bioavailable testosterone.