bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender and second language style
Authors: Guthrie Kate Hardeman 
Published: March 2017

AbstractGender has been shown to be a salient factor in acquisition of second language variation (Adamson & Regan, 1991;Major, 2004;Meyerhoff & Schleef, 2012;Rehner, Mougeon, & Nadasdi, 2003;Schleef, Meyerhoff, & Clark, 2011). However, these studies have primarily focused on learner production of target language variation and style in the sense of attention paid to speech. There has been little focus on learner perceptions of the social meanings associated with L2 variants and styles. The present article addresses this gap in the research by examining L2 learner perceptions of a gendered style of speaking in Mandarin Chinese known assajiao. Results from a perception experiment confirm the salience of gender in the acquisition of L2 variation and show that American L2 Mandarin learners have acquired some of the social meanings associated withsajiaobut not others. An acoustic phonetic analysis ofsajiaois also presented.
“Una cerbia bianchissima e bella”
Authors: Pezzè Stefano 
Published: March 2017

Considering European literature’s relationship with animals, it is immediately evident that the stag (and its feminine counterpart, the doe) performs a prominent role, and that this role has evolved considerably throughout cultures and centuries. Of further interest is the symbology associated with white stags and hinds, creatures which make several appearances in Western literature and art. Whilst the meanings they carry vary according to space and time, their main feature – being guiding animals – remains basically constant. After a presentation of the most important values of the symbol from the classics to French literature, this paper aims to explore its recurrences in Italian literature in the 14th and 15th century, in order to confirm the survival of the guiding pattern and to unravel the relationships between the Italian examples and their precedents.
Spanish validation of the Servant Leadership Short Scale for young adults and adolescents / Validación de la Escala de Liderazgo de Servicio Versión Abreviada en español para jóvenes adultos y adolescentes
Authors: Rivera Reynaldo G. , Santos David , Martín-Fernández Manuel 
Published: March 2017

The aim of the current study was to validate a shortened Spanish version of the Servant Leadership Profile (SLP). In Study 1, a number of experts evaluated and reduced the original scale to 14 items and named the revised version the Servant Leadership Short Scale (SLSS). An exploratory factor analysis conducted with a sample of 1,001 students revealed two possible structure solutions, a one-factor solution and a two-correlated factor solution. Study 2 used a different sample of 456 students to examine the explored structures using confirmatory factor analysis. A one-factor solution was proposed (χ2/ df = 3.4, CFI = .91, TLI = .90, RMSEA = .07, SRMR = .06). Finally, in Study 3, servant leadership was used as a predictor of self-efficacy ( b = .685, p < .001) and demonstrated good predictive validity. This model explained 41.55% of the variance on self-efficacy. Reliability analyses of the three studies showed that this 14-item Spanish version had high internal consistency. Together, the results of the three studies support the application of the SLSS in future research.
What is behind envy? Approach from a psychosocial perspective / ¿Qué se esconde detrás de la envidia? Aproximación desde una perspectiva psicosocial
Authors: Navarro-Carrillo Ginés , Beltrán-Morillas Ana-María , Valor-Segura Inmaculada , Expósito Francisca 
Published: March 2017

Envy strongly influences many spheres of social life. However, the psychology of envy is still in its infancy. A theoretical and empirical examination of envy was performed with a psychosocial focus via two exploratory studies. In Study 1 ( N = 141), participants were asked to describe an event in which they experienced envy, indicating which people they envied and the reasons for that envy. In Study 2 ( N = 311), the relationship between envy and several psychosocial variables such as self-efficacy, self-esteem and perceived control were analysed, as well as the predisposition to express aggressive behaviours in response to this emotion. The results of Study 1 revealed that friends were the most envied people, and abilities or personal skills were the most frequent sources of envy. Likewise, the results of Study 2 showed that self-efficacy, self-esteem and perceived control predicted envy, which in turn predicted the expression of verbal aggressive behaviours.
Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure
Authors: Fujii Kana , Saku Keita , Kishi Takuya , Oga Yasuhiro , Tohyama Takeshi , Nishikawa Takuya , Sakamoto Takafumi , Ikeda Masataka , Ide Tomomi , Tsutsui Hiroyuki , Sunagawa Kenji 
Published: March 2017

Abstract

BACKGROUND
Hypertension is a major cause of heart failure. Excessive sympathoexcitation in patients with heart failure leads to poor prognosis. Since carotid body denervation (CBD) has been shown to reduce sympathetic nerve activity in animal models of hypertension and heart failure, we examined if bilateral CBD attenuates the progression of hypertensive heart failure and improves survival.

METHODS
We randomly allocated Dahl salt-sensitive rats fed a high-salt diet from 6 weeks of age into CBD (n = 31) and sham-operation (SHAM; n = 50) groups, and conducted CBD or SHAM at 7 weeks of age. We examined the time course of 24-hour urinary norepinephrine (uNE) excretion, blood pressure (BP) and the percent fractional shortening assessed by echocardiography, and estimated the pressure–natriuresis relationship at 14 weeks of age. Finally, we assessed hemodynamics, histological findings, and survival at 16 weeks of age.

RESULTS
Compared to SHAM, CBD significantly reduced 24-hour uNE at 12, 14, and 16 weeks of age, shifted the pressure–natriuresis relationship leftward without changing its slope, and attenuated the increase in BP. CBD preserved percent fractional shortening (34.2 ± 1.2 vs. 29.1 ± 1.3%, P &lt; 0.01) and lowered left ventricular end-diastolic pressure (5.0 ± 0.9 vs. 9.0 ± 1.4 mm Hg, P &lt; 0.05). Furthermore, CBD significantly attenuated myocardial hypertrophy (P &lt; 0.01) and fibrosis (P &lt; 0.01). Consequently, CBD markedly improved survival (relative risk reduction: 64.8%).

CONCLUSIONS
CBD attenuated the progression of hypertension and worsening of heart failure possibly through sympathoinhibition, and markedly improved survival in a rat model of hypertensive heart failure.
Sequential computation of elementary modes and minimal cut sets in genome-scale metabolic networks using alternate integer linear programming
Authors: Song Hyun-Seob , Goldberg Noam , Mahajan Ashutosh , Ramkrishna Doraiswami 
Published: March 2017

AbstractMotivationElementary (flux) modes (EMs) have served as a valuable tool for investigating structural and functional properties of metabolic networks. Identification of the full set of EMs in genome-scale networks remains challenging due to combinatorial explosion of EMs in complex networks. It is often, however, that only a small subset of relevant EMs needs to be known, for which optimization-based sequential computation is a useful alternative. Most of the currently available methods along this line are based on the iterative use of mixed integer linear programming (MILP), the effectiveness of which significantly deteriorates as the number of iterations builds up. To alleviate the computational burden associated with the MILP implementation, we here present a novel optimization algorithm termed alternate integer linear programming (AILP).ResultsOur algorithm was designed to iteratively solve a pair of integer programming (IP) and linear programming (LP) to compute EMs in a sequential manner. In each step, the IP identifies a minimal subset of reactions, the deletion of which disables all previously identified EMs. Thus, a subsequent LP solution subject to this reaction deletion constraint becomes a distinct EM. In cases where no feasible LP solution is available, IP-derived reaction deletion sets represent minimal cut sets (MCSs). Despite the additional computation of MCSs, AILP achieved significant time reduction in computing EMs by orders of magnitude. The proposed AILP algorithm not only offers a computational advantage in the EM analysis of genome-scale networks, but also improves the understanding of the linkage between EMs and MCSs.Availability and ImplementationThe software is implemented in Matlab, and is provided as supplementary information.Supplementary informationSupplementary data are available at Bioinformatics online.
Creation of a Regional Human Milk Assembly
Authors: Spatz Diane L. , Evans Amanda , Froh Elizabeth 
Published: March 2017

Background:
The 2011 Surgeon General's Call to Action to Support Breastfeeding highlights a need for optimizing lactation-based education for all health professionals; however, few schools of nursing and medicine offer lactation-based curriculum. In an effort to address these gaps in education and care, the director of the lactation program at a large urban children's hospital developed and instituted the annual regional Human Milk Assembly (HMA), a half-day collaborative meeting of the hospital's regional and referral hospitals' neonatal intensive care unit (NICU) nursing staff, to address lactation-based educational and training needs of all participating institutions.

Purpose:
The purpose of this study was to determine whether and how participating HMA hospitals implemented the best practices surrounding human milk and breastfeeding shared by the host institution during a 10-year span of the HMA.

Methods:
A prospective descriptive study was designed using an electronic web-based survey (SurveyMonkey.com) to elicit participant data. Quantitative data were analyzed using descriptive statistics whereas qualitative data were analyzed for themes via content analysis.

Results:
Thirty-one of the 50 hospitals surveyed responded to the electronic survey for a total of 34 individual participants. Seventeen of the 22 (77%) of best practices were implemented at rates of over 50%.

Implications for Practice:
By enabling a culture of transparency and sharing, hospital staff can be encouraged to implement best practices across a network of regional care centers.

Implications for Research:
This annual regional HMA could be a model for other areas and research should be conducted to evaluate such programs nationwide.
Efficacy and Safety of Crystalline Valsartan/Sacubitril (LCZ696) Compared With Placebo and Combinations of Free Valsartan and Sacubitril in Patients With Systolic Hypertension: The RATIO Study
Authors: Izzo Joseph L. , Zappe Dion H. , Jia Yan , Hafeez Kudsia , Zhang Jack 
Published: March 2017

Abstract:
We compared the systolic blood pressure (SBP)-lowering efficacy and safety of crystalline valsartan/sacubitril (LCZ696, an angiotensin receptor blocker–neprilysin inhibitor) 400 mg daily against valsartan (320 mg once daily) alone or coadministered with placebo or increasing doses of free sacubitril (50, 100, 200, or 400 mg once daily) to identify the optimal antihypertensive combination dose. This multicenter, double-blinded, 7-arm parallel-group study recruited patients with mild-to-moderate systolic hypertension (office SBP 150–179 mm Hg). Primary-dependent variable was change in office SBP from baseline to week 8. At entry (n = 907), mean age was 61.5 years, sitting office BP 160/90.2 mm Hg, and mean 24-hour ambulatory BP 142/82.1 mm Hg; 852 participants completed the study. At week 8, there were greater reductions in sitting office SBP and 24-hour ambulatory SBP with LCZ696 400 mg than with valsartan 320 mg (−5.7 and −3.4 mm Hg, respectively, P < 0.05 each). The SBP reduction with LCZ696 400 daily was similar to coadministered free valsartan 320 mg and sacubitril 200 mg. Effects were similar in those older and younger than 65 years, and active therapies had adverse event rates similar to placebo. We conclude that crystalline valsartan/sacubitril 400 mg daily (1) is superior to valsartan 320 mg daily for lowering SBP, (2) has similar efficacy to the combination of free valsartan 320 mg plus free sacubitril 200 mg, (3) represents the optimal dosage for systolic hypertension in patients of any age, and (4) is safe and well tolerated.
A Slight Smell of Lemon
Authors: Feliu Catherine , Cazaubon Yoann , Fouley Aurélie , Guillemin Hélène , Gozalo Claire , Djerada Zoubir 
Published: March 2017

Abstract:
We present here an example of urine substituted with a yellow cleaning product that leads us to develop the main risks to consider in urine toxicology analysis, ie, adulteration and analytical interferences, and how to deal with them. This grand round highlights the importance of the dialog between the clinician and a TDM consultant for optimal care of the patient.
SUCCESSFUL CLOSURE OF FULL-THICKNESS MACULAR HOLES SECONDARY TO MACULAR VITELLIFORM LESIONS
Authors: Galvin Justin C. , Chua Brian E. , Fung Adrian T. 
Published: March 2017

Purpose:
To describe the first reported cases of full-thickness macular holes secondary to vitelliform lesions that were successfully closed with vitrectomy surgery and gas tamponade.

Methods:
Two female patients developed visual loss secondary to bilateral vitelliform lesions and associated full-thickness macular holes. The patients underwent 25-gauge pars plana vitrectomy, internal limiting membrane peeling, and 26% sulfur hexafluoride gas, followed by 3 days of face-down positioning.

Results:
In both patients, the macular holes remain closed 3 and 25 months postoperatively.

Conclusion:
Vitrectomy surgery with gas tamponade may successfully close full-thickness macular holes secondary to macular vitelliform lesions.
PRESUMED RETINAL PIGMENT EPITHELIUM TUMOR ORIGINATING FROM UNILATERAL RETINAL PIGMENT EPITHELIUM DYSGENESIS
Authors: Gal-Or Orly , Finger Paul T. , Fisher Yale L. , Yannuzzi Lawrence A. , Freund K. Bailey 
Published: March 2017

Purpose:
To describe a patient with a presumed retinal pigment epithelium (RPE) tumor originating from unilateral RPE dysgenesis.

Methods:
Case report.

Results:
A 30-year-old woman with an unremarkable medical and ocular history was referred for an evaluation of progressive central metamorphopsia in her left eye. Visual acuity was 20/20 in her right eye and 20/25 in her left eye. Funduscopic examination of the left eye revealed an elevated mass within an area of unilateral RPE dysgenesis showing hyperpigmentation and hypopigmentation with scalloped margins. Fundus autofluorescence of the lesion showed a marginal pattern of hyperautofluorescence and hypoautofluorescence that was the inverse of the fluorescein angiography pattern. A well-circumscribed subretinal mass appeared to originate from the unilateral RPE dysgenesis lesion with surrounding subretinal fluid extending beneath the fovea. Ultrasonography showed medium-to-high reflectivity of the mass with no evidence of choroidal involvement. Optical coherence tomography showed a subretinal hyporeflective mass consistent with a tumor of RPE origin. The tumor appeared to invade the overlying retina where fluorescein angiography showed hyperfluorescent leakage and OCT angiography showed retinal vascular deformation. Indocyanine green angiography showed no evidence of choroidal neovascularization. Findings in the right fundus were normal. Over a 5-month follow-up, intravitreal anti–vascular endothelial growth factor therapy induced a resolution of subretinal exudation and modest reduction in tumor thickness.

Conclusion:
To the authors' knowledge, this is the first report of a presumed RPE tumor described as originating from unilateral RPE dysgenesis. Multimodal imaging was crucial for establishing the diagnosis and showing that the patient's visual symptoms were a product of the exudation produced by the tumor's invasion of the retina.
SEROUS RETINOPATHY ASSOCIATED WITH CISPLATIN TREATMENT
Authors: Langevin Spencer , Chang Jonathan S. , Chang Stanley 
Published: March 2017

Background/Purpose:
To describe a case of serous retinopathy and associated photoreceptor atrophy after intravenous cisplatin therapy.

Methods:
Evaluation was performed using electroretinogram, optical coherence tomography, fundus autofluorescence, and funduscopic examinations to assess the extent of retinal disease, toxicity, and eventual atrophy.

Results:
A 56 year-old man with metastatic small cell carcinoma with vision changes after initiation of cisplatin therapy. The patient developed loss of vision to 20/400. A serous retinopathy was found on spectral domain optical coherence tomography with associated outer retinal atrophy and subretinal fibrosis. He developed outer ellipsoid layer atrophy after discontinuation of cisplatin therapy. He had patchy hypoautofluorescent areas in his macula on fundus autofluorescence and decreased cone response and slowed b-wave on electroretinogram. The serous retinopathy resolved with discontinuation of cisplatin and the malignancy was further managed with etoposide without recurrence of subretinal serous fluid or further vision loss.

Conclusion:
Commonly used to treat various solid tumors, cisplatin is not without significant neurologic, ocular, and retinal toxicities. Multimodal imaging may further the authors' understanding of toxicity and this case highlights the benefits of optical coherence tomography, especially with color vision deviation or visual acuity change.
RE-INTERVENTION IN DE NOVO VITREOUS OPACITIES AFTER PARS PLANA VITRECTOMY IN FAMILIAL AMYLOIDOTIC POLYNEUROPATHY TTR VAL30METPORTUGUESE PATIENTS
Authors: Ferreira Natália Novais , Cunha Dias David Afonso , Afonso Carvalho Rui Pedro , Pardal Monteiro Coelho Maria Teresa 
Published: March 2017

Purpose:
To report management of de novo vitreous amyloid opacities after previous pars plana vitrectomy in familial amyloidotic polyneuropathy transthyretin Val30Met.

Methods:
This work is a retrospective observational consecutive case series of five eyes of four patients. Demographic data, transthyretin mutation involved, age at the beginning of disease, duration of disease, treatment (liver transplant or tafamidis), time between vitrectomy and re-intervention, and ophthalmologic changes were evaluated. Surgical re-intervention included phacoemulsification with intraocular lens implantation in phakic eyes, re-vitrectomy as complete as possible with posterior capsulectomy, and internal limiting membrane peeling if wrinkling of internal retinal surface was present.

Results:
All patients had transthyretin Val30Met mutation, and three were women. Mean age of onset of the disease was 52 ± 11.0 years, and average evolution time of the disease was 8 years. Three patients had been submitted to liver transplant 4, 9, and 15 years before. Time between first vitrectomy and surgical re-intervention was longer than 2 years in all cases. Two eyes had amyloid deposits on anterior lens surface and pupillary border with scalloped pupil. Two eyes were phakic. Glaucoma was present in two eyes; one of them had previous trabeculectomy. All cases had vitreous opacities behind posterior lens capsule and at vitreous base area. After re-intervention, no further recurrence was observed (average follow-up of 10 months).

Conclusion:
De novo vitreous amyloid opacities may occur several years after pars plana vitrectomy. Amyloid deposition in vitreous cavity was observed only in strong vitreous adherence locations (behind posterior lens capsule and at vitreous base area). The authors expect that this procedure, an extensive re-vitrectomy associated with posterior capsulectomy, will prevent de novo vitreous amyloid opacities.
EXTREME DIURNAL VARIATION OF CENTRAL MACULAR THICKNESS IN DIABETIC MACULAR EDEMA
Authors: Sambhav Kumar , Grover Sandeep , Chalam Kakarla V. 
Published: March 2017

Purpose:
Spectral domain optical coherence tomography is an established modality to quantify diabetic macular edema (DME). Change in central subfield thickness exceeding 3% to 6% in DME is likely to be significant. In this case of DME, we describe an extreme bilateral variation in central macular thickness on spectral domain optical coherence tomography over two consecutive days without any treatment.

Methods:
The patient with DME and nonproliferative diabetic retinopathy underwent visual acuity testing, slit-lamp biomicroscopy, and dilated fundus examination. The patient also underwent spectral domain optical coherence tomography and digital fluorescence angiography. Findings are described in case report.

Results:
There was an overnight decrease of central subfield thickness from 360 microns to 291 microns (69 [∼19%] microns) in the right eye and from 404 microns to 293 microns (111 [∼27%] microns) in the left eye.

Conclusion:
Extreme fluctuations in retinal thickness in central involving DME are unusual, and the exact mechanism of this fluctuation is poorly understood.
Magnetic Resonance Imaging Characteristics of a Baerveldt Glaucoma Implant
Authors: Anderson Daniel M. , Schwope Ryan B. , Reiter Michael J. , Suhr Abraham W. 
Published: March 2017

Purpose:
Evaluate for normative postoperative magnetic resonance imaging (MRI) characteristics of a Baerveldt Glaucoma Implant (BGI).

Design:
Prospective case series.

Participants:
Seven subjects with uncontrolled glaucoma requiring a primary superotemporal BGI.

Methods:
Subjects prospectively underwent sequential MRI orbital scans without contrast at 0 to 2 weeks, 6 to 8 weeks, and 4 to 6 months after implantation of a BGI model 103-250. Masked to the postoperative time course, a radiologist measured bleb and implant characteristics.

Main Outcome Measures:
Linear measurements of the maximum bleb height at the anterior, middle, and posterior sections of the endplate were measured. Intraocular pressure (IOP) was correlated to bleb height.

Results:
On axial T2-weighted images, the height of fluid below and above the BGI endplate increased from the initial to the final MRI images: 0.49 mm to 1.83 mm and 0.57 mm to 1.08 mm (middle 1/3), respectively. On coronal T2-weighted images, fluid below and above the BGI endplate increased from 0.47 mm to 1.53 mm and 0.49 mm to 1.38 mm, respectively. Maximum inverse correlation between bleb height and IOP was observed at the 6 to 8 week coronal T2 images (r=−0.963, P=0.002).

Conclusions:
Fluid collections and endplate characteristics are easily visualized with MRI. Dynamic changes occur over the early postoperative time course. Bleb height is inversely correlated to IOP at 6 to 8 weeks, but disappears at 4 to 6 months.
Building Research Infrastructure in Magnet® Hospitals
Authors: Johantgen Meg , Weiss Marianne , Lundmark Vicki , Newhouse Robin , Haller Karen , Unruh Lynn , Shirey Maria 
Published: March 2017

OBJECTIVE
The aim of this study was to describe the infrastructures supporting research in Magnet® hospitals.

BACKGROUND
Hospitals undertaking the journey toward Magnet designation must build research and evidence-based practice (EBP) infrastructures that support the infusion of research and EBP into clinical practice.

METHODS
An electronic survey was developed and distributed to the chief nursing officer or Magnet coordinator of all Magnet hospitals between June 10, 2015, and July 8, 2015.

RESULTS
Of the 418 Magnet hospitals invited, 249 responses (60%) were received. Resources dedicated to nursing research were difficult to isolate from those for EBP. Supporting clinical nurses’ time away from the bedside remains a challenge. Nearly half (44%) indicated that research is conducted within the nurses’ usual clinical hours, and 40% indicated that nurses participate on their own time.

CONCLUSIONS
Hospitals use a variety of resources and mentor arrangements to support research and EBP, often the same resources. More targeted resources are needed to fully integrate research into clinical practice.