bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of hepatitis B virus reactivation in systemic lupus erythematosus patients receiving immunosuppressants: a retrospective cohort study
Authors: Lin W T , Chen Y M , Chen D Y , Lan J L , Chang C S , Yeh H Z , Yang S S 
Published: May 2017

Objective We aimed to investigate risk of hepatitis B virus reactivation in systemic lupus erythematosus patients with different hepatitis B virus infection statuses receiving immunosuppressive therapy. Methods We retrospectively analyzed systemic lupus erythematosus patients with positive hepatitis B surface antigen or anti-hepatitis B core IgG antibody who underwent immunosuppressive therapies from January 2001 to December 2012 at a medical center in Taiwan for evidence of hepatitis B virus reactivation. Results During this period, 906 out of 3125 patients who were diagnosed with systemic lupus erythematosus received screening tests for hepatitis B virus. Thirty-eight patients were identified as hepatitis B surface antigen-positive. Fifteen of 38 (39.5%) hepatitis B surface antigen-positive patients developed hepatitis B virus reactivation, and 53.3% of these patients experienced severe hepatitis flare. Three of 157 hepatitis B surface antigen-negative/anti-hepatitis B core IgG antibody-positive patients (1.9%) experienced hepatitis B surface antigen seroreversion after immunosuppressive therapy. Five patients received prophylactic or preemptive antiviral therapy and none of them developed hepatitis B virus flares. A daily dose of prednisolone greater than 5 mg was a risk factor for hepatitis B reactivation by multivariate logistic analysis. Conclusions The risk of hepatitis B virus reactivation is high in lupus patients receiving immunosuppressive therapy. Antiviral prophylaxis or preemption can effectively reduce the incidence of hepatitis B virus reactivation in lupus patients.
Intra-observer repeatability when assessing the foetal urinary bladder volume by the Virtual Organ Computer-aided AnaLysis and SUM-OF-CYLINDERS methods: A pilot study
Authors: Fagerquist Mats A , Sethi Vivek , Skytteren Eli , Oden Anders 
Published: May 2017

Introduction The aim of this study was to compare the intra-observer repeatability when using two different methods for estimating the volume of foetal urinary bladders. Method The urinary bladders of 20 foetuses were documented by three-dimensional ultrasound. Standard deviation was compared when the volumes of identical bladder images were repeatedly estimated using the Virtual Organ Computer-aided AnaLysis and the experimental SUM-OF-CYLINDERS methods. Results No systematic deviation was found between the estimated volumes when using these two methods. Standard deviation was smaller for the SUM-OF-CYLINDERS compared to the Virtual Organ Computer-aided AnaLysis method (p < 0.0001). In relation to bladder volumes of 5–25 ml, standard deviation was 11–14% for the Virtual Organ Computer-aided AnaLysis and 4–5% for the SUM-OF-CYLINDERS method. Conclusions Using three-dimensional ultrasound images adapted for the Virtual Organ Computer-aided AnaLysis method, foetal urinary bladder volumes can also be estimated using the SUM-OF-CYLINDERS method. The SUM-OF-CYLINDERS method employs technical advances which may result in a lower standard deviation and therefore higher intra-observer repeatability.
Establishing the appropriate position of proximal humerus locking plates: a cadaveric study of five plating systems and their anatomic reference measurements
Authors: Butler Matthew A , Chauhan Aakash , Merrell Gregory A , Greenberg Jeffrey A 
Published: May 2017

Background The present study aimed to determine anatomic references for the placement of five proximal humerus locking plates. Methods Five proximal humerus locking-plate systems were placed on six human shoulder cadavers. Plates were positioned by fluoroscopic confirmation so that the inferior oblique screw was within 5 mm of the inferomedial cortex. Plate position was measured using the superior border of the pectoralis major tendon (PMT) to the bottom of the first slotted or nonlocking hole and top of the plate to the top of the greater tuberosity. The distance from the PMT insertion to the top of the humeral head was measured as a control. Results There was consistency within each plating system for both the distance from the PMT insertion to the first hole and the top of the plate to the greater tuberosity: Synthes first-generation [mean (SD) 13.7 mm (3.1 mm); 10 mm (1.3) mm], Synthes second-generation [28.2 mm (2.2 mm); 18.5 mm (2.7 mm)], Biomet OptiLock® [25.5 mm (2.7 mm); 18.7 mm (2 mm)], Stryker AxSOS® [5 mm (2.8 mm); 12.3 mm (3.3 mm)] and Acumed Polarus® [9.5 mm (1.8 mm); 14.8 mm (1.6 mm)]. Conclusions The present study provides measurements that improve the accuracy of plate positioning for five plating systems.
Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial
Authors: Hangody Laszlo , Szody Robert , Lukasik Piotr , Zgadzaj Wojciech , Lénárt Endre , Dokoupilova Eva , Bichovsk Daniela , Berta Agnes , Vasarhelyi Gabor , Ficzere Andrea , Hangody György , Stevens Gary , Szendroi Miklos 
Published: May 2017

Objective: To evaluate the efficacy and safety of an intraarticular injection of Cingal (Anika Therapeutics, Inc., Bedford, MA) compared with Monovisc (Anika Therapeutics, Inc., Bedford, MA) or saline for the treatment of knee osteoarthritis. Design: This multicenter, double-blind, saline-controlled clinical trial randomized subjects with knee osteoarthritis (Kellgren-Lawrence grades I-III) to a single injection of Cingal (4 mL, 88 mg hyaluronic acid [HA] plus 18 mg triamcinolone hexacetonide [TH]), Monovisc (4 mL, 88 mg HA), or saline (4 mL, 0.9%). The primary efficacy outcome was change in WOMAC (Western Ontario and McMaster Universities Arthritis Index) Pain Score through 12 weeks with Cingal versus saline. Secondary outcomes included Patient and Evaluator Global Assessments, OMERACT-OARSI Responder index, and WOMAC Total, Stiffness, and Physical Function scores through 26 weeks. Results: A total of 368 patients were treated (Cingal, n = 149; Monovisc, n = 150; saline, n = 69). Cingal improvement from baseline was significantly greater than saline through 12 weeks ( P = 0.0099) and 26 weeks ( P = 0.0072). WOMAC Pain was reduced by 70% at 12 weeks and by 72% at 26 weeks with Cingal. Significant improvements were found in most secondary endpoints for pain and function at most time points through 26 weeks. At 1 and 3 weeks, Cingal was significantly better than Monovisc for most endpoints; Cingal and Monovisc were similar from 6 weeks through 26 weeks. A low incidence of related adverse events was reported. Conclusions: Cingal provides immediate and long-term relief of osteoarthritis-related pain, stiffness, and function, significant through 26 weeks compared to saline. Cingal had similar immediate advantages compared with HA alone, while showing benefit comparable to HA at 6 weeks and beyond.
The HEART score for early rule out of acute coronary syndromes in the emergency department: a systematic review and meta-analysis
Authors: Van Den Berg Patricia , Body Richard 
Published: May 2017

Aims: The objective of this systematic review was to summarise the current evidence on the diagnostic accuracy of the HEART score for predicting major adverse cardiac events in patients presenting with undifferentiated chest pain to the emergency department. Methods and results: Two investigators independently searched Medline, Embase and Cochrane databases between 2008 and May 2016 identifying eligible studies providing diagnostic accuracy data on the HEART score for predicting major adverse cardiac events as the primary outcome. For the 12 studies meeting inclusion criteria, study characteristics and diagnostic accuracy measures were systematically extracted and study quality assessed using the QUADAS-2 tool. After quality assessment, nine studies including data from 11,217 patients were combined in the meta-analysis applying a generalised linear mixed model approach with random effects assumption (Stata 13.1). In total, 15.4% of patients (range 7.3–29.1%) developed major adverse cardiac events after a mean of 6 weeks’ follow-up. Among patients categorised as ‘low risk’ and suitable for early discharge (HEART score 0–3), the pooled incidence of ‘missed’ major adverse cardiac events was 1.6%. The pooled sensitivity and specificity of the HEART score for predicting major adverse cardiac events were 96.7% (95% confidence interval (CI) 94.0–98.2%) and 47.0% (95% CI 41.0–53.5%), respectively. Conclusions: Patients with a HEART score of 0–3 are at low risk of incident major adverse cardiac events. As 3.3% of patients with major adverse cardiac events are ‘missed’ by the HEART score, clinicians must ask whether this risk is acceptably low for clinical implementation.
Silicone Oil in Optic Chiasm: Case Report and Review of the Literature
Authors: Shanmugam Mahesh P. , Gopal Swaroop , Reddy Rajiv , Ramanjulu Rajesh , Mishra Divyansh K. C. , Sagar Pradeep 
Published: May 2017

Purpose: To report a case of silicone oil migration into optic chiasm with resultant visual field defect in the fellow eye. We also summarize the risk factors and pathogenic mechanisms responsible for the silicone oil migration and the subsequent neurological effects associated with it. Methods: A 36-year-old gentleman presented with a history of vitrectomy with silicone oil tamponade in the left eye with sudden-onset temporal field defect in the right eye. Silicone oil was identified in left optic nerve and left half of optic chiasm. Intrachiasmatic and intraneural silicone oil was removed by left pterional craniotomy. Result: Prompt visual field recovery in the right eye after the neurosurgical intervention was noted. Conclusion: Intracranial migration of silicone oil is rare, with only a handful of cases reported in the literature. Intrachiasmal and intraneural silicone oil is associated with loss of nerve fibers and resultant vision and visual field loss. Prompt neurosurgical intervention results in the improvement of visual field defects. So early identification and neurosurgical intervention is warranted. Vitreoretinal surgeons should be aware of transneural migration of silicone oil, and a high degree of suspicion is warranted when patient develops visual symptoms in the fellow eye, particularly in cases with glaucomatous optic neuropathy and secondary elevated intraocular pressure or in any disc malformation.
Acquired resistance to macrolides inPseudomonas aeruginosafrom cystic fibrosis patients
Authors: Mustafa Muhammad-Hariri , Khandekar Shaunak , Tunney Michael M. , Elborn J. Stuart , Kahl Barbara C. , Denis Olivier , Plésiat Patrick , Traore Hamidou , Tulkens Paul M. , Vanderbist Francis , Van Bambeke Françoise 
Published: May 2017

Cystic fibrosis (CF) patients receive chronic treatment with macrolides for their antivirulence and anti-inflammatory properties. We, however, previously showed thatPseudomonas aeruginosa, considered as naturally resistant to macrolides, becomes susceptible when tested in a eukaryotic medium rather than a conventional broth.We therefore looked for specific macrolide resistance determinants in 333 CF isolates from four European CF centres in comparison with 48 isolates from patients suffering from hospital-acquired pneumonia (HAP).Minimum inhibitory concentrations (MICs) of macrolides and ketolides measured in eukaryotic medium (RPMI-1640) were higher towards CF than HAP isolates. Gene sequencing revealed mutations at three positions (2045, 2046 and 2598) in domain V of 23S rRNA of 43% of sequenced CF isolates, but none in HAP isolates. Enzymes degrading extracellular polymeric substances also reduced MICs, highlighting a role of the mucoid, biofilm-forming phenotype in resistance. An association between high MICs and chronic azithromycin administration was evidenced, which was statistically significant for patients infected by the Liverpool Epidemic Strain.Thus, ribosomal mutations are highly prevalent in CF isolates and may spread in epidemic clones, arguing for prudent use of oral macrolides in these patients. Measuring MICs in RPMI-1640 could be easily implemented in microbiology laboratories to phenotypically detect resistance.
Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study
Authors: Xu Jingyuan , Peng Xiao , Pan Chun , Cai Shixia , Zhang Xiwen , Xue Ming , Yang Yi , Qiu Haibo 
Published: May 2017

Abstract
Background
Significant effort has been devoted to defining parameters for predicting fluid responsiveness. Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO2) in the critically ill patients.

Methods
This was a single-center prospective study conducted in the intensive care unit of a tertiary care teaching hospital. Shock patients who presented with at least one clinical sign of inadequate tissue perfusion, defined as systolic blood pressure <90 mmHg or a decrease >40 mmHg in previously hypertensive patients or the need for vasopressive drugs; urine output <0.5 ml/kg/h for 2 h; tachycardia; lactate >4 mmol/l, for less than 24 h in the absence of a contraindication for fluids were eligible to participate in the study. PtcO2 was continuously recorded before and during a passive leg raising (PLR) test, and then before and after a 250 ml rapid saline infusion in 10 min. Fluid responsiveness is defined as a change in the stroke volume ≥10% after 250 ml of volume infusion.

Results
Thirty-four patients were included, and 14 responded to volume expansion. In the responders, the mean arterial pressure, central venous pressure, cardiac output, stroke volume and PtcO2 increased significantly, while the heart rate decreased significantly by both PLR and volume expansion. Changes in the stroke volume induced either by PLR or volume expansion were significantly greater in responders than in non-responders. The correlation between the changes in PtcO2 and stroke volume induced by volume expansion was significant. Volume expansion induced an increase in the PtcO2 of 14% and PLR induced an increase in PtcO2 of 13% predicted fluid responsiveness.

Conclusions
This study suggested the changes in PtcO2 induced by volume expansion and a PLR test predicted fluid responsiveness in critically ill patients.
Trial registration NCT02083757.
Designing Clinical Trials That Accept New Arms: An Example in Metastatic Breast Cancer
Authors: Ventz Steffen , Alexander Brian M. , Parmigiani Giovanni , Gelber Richard D. , Trippa Lorenzo 
Published: May 2017

Purpose The majority of randomized oncology trials are two-arm studies that test the efficacy of new therapies against a standard of care, thereby assigning a large proportion of patients to nonexperimental therapies. In contrast, multiarm studies efficiently share a common control arm while evaluating multiple experimental therapies. A major bottleneck for traditional multiarm trials is the requirement that all therapies—often drugs from different companies—have to be available at the same time when the trial starts. We evaluate the potential gains of a platform design—the rolling-arms design—that adds and removes arms on a rolling basis. Methods We define the rolling-arms design with the goal of minimizing the complexity of random assignment and data analyses of a platform trial. We then evaluate its potential advantages in hormone receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer. Multiple pharmaceutical companies currently test CDK4/6 inhibitors in combination with letrozole in independent two-arm trials. We conducted a simulation study to quantify the reduction in sample size, number of patients treated with the standard of care, and the average time to treatment discovery if these therapies had been tested in a rolling-arms trial. Results A rolling-arms platform design with two to five experimental treatments can reduce the overall sample size requirement by up to 30% compared with standard two-arm studies. It assigns up to 60% fewer patients to the control arm compared with five independent trials that test distinct treatments. Moreover, under realistic scenarios, effective experimental treatments are discovered up to 15 months earlier compared with separate two-arm trials. Conclusion The rolling-arms platform design is applicable to a broad variety of diseases, and under realistic scenarios, it is substantially more efficient than standard two-arm randomized trials.
Transitionings and Returnings
Authors: Silva Santana Dora 
Published: May 2017

Abstract
The author takes her escrevivência as a Brazilian black trans woman and experiments with the poetics of Atlantic water to let the text itself be a transitioning space of poetics-autoethnography-cosmology-water-energy-memory tissue. Water is the riverine thread that runs through the sections of this text, be it as rain, as tears, as sea, as metaphor, as body, as energy. The author suggests that, for black trans people in the African diaspora, trans travel narratives evoke the metaphor of transitioning in the similar ways that M. Jacqui Alexander works with the metaphor of the crossing, which not only recalls the embodied memory of the disembodied in the “tidal current of the Middle Passage” but also “evokes/invokes crossroads, the space of convergence and endless possibility.”
Competitive Mobile Geo Targeting
Authors: Chen Yuxin , Li Xinxin , Sun Monic 
Published: May 2017

We investigate in a competitive setting the consequences of mobile geo targeting, the practice of firms targeting consumers based on their real-time locations. A distinct market feature of mobile geo targeting is that a consumer could travel across different locations for an offer that maximizes his total utility. This mobile-deal seeking opportunity motivates firms to carefully balance prices across locations to avoid intrafirm cannibalization, which in turn mitigates interfirm price competition and prevents firms from going into a prisoner’s dilemma. As a result, a firm’s profit can be higher under mobile geo targeting than under uniform or traditional targeted pricing. We extend our model in three different directions: (a) a fraction of consumers are not aware of mobile offers outside of their permanent locations, (b) mobile offers can be collected when consumers travel for other reasons, and (c) firms use both permanent and real-time locations when setting prices. Our findings have important managerial implications for marketers who are interested in optimizing their mobile geo-targeting strategies. The online appendix is available at https://doi.org/10.1287/mksc.2017.1030 .
High-Resolution Mapping of Crossover Events in the Hexaploid Wheat Genome Suggests a Universal Recombination Mechanism
Authors: Darrier Benoit , Rimbert Hélène , Balfourier François , Pingault Lise , Josselin Ambre-Aurore , Servin Bertrand , Navarro Julien , Choulet Frédéric , Paux Etienne , Sourdille Pierre 
Published: May 2017

Abstract
During meiosis, crossovers (COs) create new allele associations by reciprocal exchange of DNA. In bread wheat (Triticum aestivum L.), COs are mostly limited to subtelomeric regions of chromosomes, resulting in a substantial loss of breeding efficiency in the proximal regions, though these regions carry ∼60–70% of the genes. Identifying sequence and/or chromosome features affecting recombination occurrence is thus relevant to improve and drive recombination. Using the recent release of a reference sequence of chromosome 3B and of the draft assemblies of the 20 other wheat chromosomes, we performed fine-scale mapping of COs and revealed that 82% of COs located in the distal ends of chromosome 3B representing 19% of the chromosome length. We used 774 SNPs to genotype 180 varieties representative of the Asian and European genetic pools and a segregating population of 1270 F6 lines. We observed a common location for ancestral COs (predicted through linkage disequilibrium) and the COs derived from the segregating population. We delineated 73 small intervals (&lt;26 kb) on chromosome 3B that contained 252 COs. We observed a significant association of COs with genic features (73 and 54% in recombinant and nonrecombinant intervals, respectively) and with those expressed during meiosis (67% in recombinant intervals and 48% in nonrecombinant intervals). Moreover, while the recombinant intervals contained similar amounts of retrotransposons and DNA transposons (42 and 53%), nonrecombinant intervals had a higher level of retrotransposons (63%) and lower levels of DNA transposons (28%). Consistent with this, we observed a higher frequency of a DNA motif specific to the TIR-Mariner DNA transposon in recombinant intervals.
Coherent Lattice Vibrations in Bi and Sb
Authors: Vidal J. , Cheng T. K. , Zeiger H. J. , Dresselhaus G. , Dresselhaus M. S. , Ippen E. P. 
Published: May 2017

AbstractFemtosecond time-resolved optical techniques have been shown to generate coherent phonons in some semimetals and narrow gap semiconductors. A previously-reported model describes the mechanism for generation of coherent lattice vibrations via the optically excited carriers. One of the most interesting consequences of such coherent lattice motion is the modulation of the electronic bands - and possibly of the transport properties of the material — at a THz timescale. Preliminary results are given for a band structure calculation, performed to evaluate the magnitude of these laser-induced band shifts.
Two Effective Methods for Improving the Output of NaCl(OH-): Color Center Laser
Authors: Jihuai Wu , Chenghuang Xu , Miaoliang Huang , Bizhou Lin 
Published: May 2017

AbstractThis paper reports two effective methods for improving the output of NaCl (OH-): color center laser. The first are eliminating the laser non – active color centers and enhancing the concentration of color center in laser crystal; The second is chosing the auxiliary light with suitable wavelength, such as 0. 475μm, during laser operation. The authors also discuss and interpretate the two methods in the paper.
Energy Transfer Between Two Sites in Nd3+:KLiYF5
Authors: Weidner H. , Summers P. L. , Peale R. E. , Chai B. H. T. 
Published: May 2017

AbstractHigh resolution spectroscopy of Nd3+ in Potassium Lithium Yttrium Fluoride (KLiYF5 ) at ≤80 K reveals two crystal-field sites which are equally populated independent of concentration. Site selective excitation of photoluminescence distinguishes each site's contribution to the spectra. The analysis of integrated line intensities reveals a bidirectional energy transfer between Nd3+ ions in different sites. A rapid increase in transfer rate with increasing Nd concentration is explained only if non-radiative transfer via exchange interaction contributes strongly to the effect. The observed relative decrease with increasing concentration of those emission lines which overlap strongly with opposite-site absorption lines implies that radiative transfer is also important. The energy transfer strongly depends on temperature (2 K – 80 K) which indicates the participation of phonons.
Fabrication of Potassium Titanyl Phosphate Films by Pulsed Excimer Laser Ablation for Nonlinear Optical Application
Authors: Xiong Fulin , Hagerman M. E. , Zhou H. , Lundquist P. M. , Wong G. K. , Poeppelmeier K. P. , Ketterson J. B. , Chang R. P. H. , White C. W. 
Published: May 2017

AbstractWe have fabricated highly-orientated crystalline potassium titanyl phosphate (KTP) films on a variety of substrates by pulsed excimer laser ablation. The resulting films have been extensively characterized in terms of their compositional, crystalline, and optical properties. Nonlinear optical property of secondary harmonic generation of the films has been evaluated with a high d value comparable to that of KTP bulk crystals. The results are encouraging that the KTP films deposited are very promising for nonlinear optical waveguide device applications.