bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of TPOAb on Embryologic and Pregnancy Outcomes Among Infertile PCOS Patients with Euthyroidism Undergoing IVF/ICSI Cycle: A Retrospective Cohort Study
Authors: Yang Hui-Jun , Liu Jiaojing , Zhou Li-Yang , Geng Li-Hong , Fang-Di Dong , Fu LiJuan , Guang-Yan Gu , Na Yu , Shi-Yu Liu , Ding Yubin 
Published: October 2024

Abstract

Background PCOS is a complex endocrine disorder affecting fertility. PCOS patients combined with TAI have a higher risk of reproductive complications. The interplay between TAI and PCOS in the context of ART outcomes represents an unsolved problem. Therefore, the relationship between TPOAb and embryologic or pregnancy outcomes of IVF/ICSI in a cohort of infertile female patients diagnosed PCOS with euthyroidism should be evaluated.
Methods A retrospective cohort study is conducted. After selected with standard diagnostic code, strict inclusion and exclusion criteria and 1:4 PSM, 62 PCOS patients with TPOAb positive matched with 216 TPOAb negative PCOS patients from October 2014 to September 2022 are included in the study. The primary outcomes are live birth rate and clinical pregnancy rate, and secondary outcomes include other pregnancy-related outcomes and laboratory parameters related to embryologic quality.
Results In the TPOAb-positive group, fertilization rate, 2PN fertilization rate, and 2PN cleavage rate are significantly higher than those in the TPOAb-negative group (P < 0.05). However, TPOAb levels are not significantly associated with those embryo parameters in two groups after adjusting for propensity scores (P > 0.05). Then, we show that there are no correlation between TPOAb and pregnancy outcomes in TPOAb-positive and TPOAb-negative PCOS populations (P > 0.05).
Conclusions TPOAb is not a risk factor for embryonic or pregnancy outcomes in PCOS patients with euthyroidism undergoing IVF/ICSI. TPOAb-positive indicator should not be paid too much attention, and does not need to be overtreated for PCOS patients with euthyroidism undergoing IVF/ICSI.
Male sex accelerates cognitive decline in GBA1 Parkinson’s Disease
Authors: Caminiti Silvia , Avenali Micol , Galli Alice , Malito Rachele , Cuconato Giada , Galandra Caterina , Calabrese Rosaria , pilotto Andrea , Padovani Alessandro , Blandini Fabio , Perani Daniela , Tassorelli Cristina , Valente Enza Maria 
Published: October 2024

Abstract

We evaluated 128 GBA and 432 nonGBA Parkinson’s disease (PD) subjects. Baseline clinical features and dopaminergic activity were assessed, together with 7-year clinical follow-up. Survival analyses assessed the independent and interactive effects of male sex and GBA1 mutations on cognitive impairment. At baseline, GBA-PD males showed greater motor impairment, sleep disorders and memory deficits, GBA-PD females showed greater dopaminergic denervation. In longitudinal assessment, GBA-PD males showed greater MoCA rate of change per year and greater risk of cognitive impairment than GBA-PD females and nonGBA-PD, also when excluding subjects with LRRK2 mutations. In GBA-PD males, both late age at onset and “severe/mild” GBA variants were associated with increased risk of cognitive impairment. Male sex and GBA1 carrier status have an additive value in increasing the risk of cognitive decline in PD. The effect of sex on GBA1-related pathology warrants further examination to address future trials design and patients’ selection.
Basilar artery and posterior circulation collaterals score on digital subtraction angiography predicts prognosis for acute basilar artery occlusion treated with endovascular thrombectomy
Authors: Shen Guangxun , Zhao Jingmin , Piao Zhe , Mao Ying , Zhang Li , Lee Kwee-yum , Chi Lumei , Nan Guangxian 
Published: October 2024

Abstract

Background and purpose
The prognosis of acute basilar artery occlusion (BAO) is poor, carrying a high risk of disability and mortality if left untreated. Several radiological scores may predict the clinical outcome of acute BAO treated with endovascular thrombectomy (EVT). This study aims to assess the prognostic value of a novel radiological score, the Basilar Artery and Posterior Circulation Collaterals (BAPCOR) score.
Methods
A retrospective analysis was performed on consecutive acute BAO patients treated with EVT. The BAPCOR score, a 15-point digital subtraction angiography (DSA)-based grading system, was used to assess thrombus burden and posterior circulation collateral status. Successful recanalization was defined as a modified thrombolysis in cerebral infarction (mTICI) score 2b-3, and a good outcome was defined by a modified Rankin Scale (mRS) score of ≤ 2 at 3 months. Receiver operating characteristic (ROC) curve determined the area under the curve (AUC) and the optimum cutoff value. Multivariate regression analysis was used to identify predictors of clinical outcome.
Results
Among the enrolled patients, 85.1% (40/47) achieved successful recanalization (mTICI, 2b-3) and 34.0% (16/47) had a good outcome (mRS score 0–2). The ROC analysis indicated that the AUC of the BAPCOR score was 0.868 (95%CI: 0.753–0.983). A cut-off value of predicting poor outcome was set at 8.5, with sensitivity of 0.688 and specificity of 0.935. Correlation analysis showed a moderate negative correlation between BAPCOR and mRS.
Conclusion
The BAPCOR scoring system is associated with outcomes in acute BAO patients treated with EVT with superiority in reflecting thrombus burden and collateral status.
Hall impact on hybrid Sisko-nanofluid flow past a stretchable cylinder with Cattaneo-Christov Heat flux
Authors: El-Hamid Mohamed A , Dahab Emad M Abo-El , El-Aziz Mohamed Abd , Salem Ahmed M 
Published: October 2024

Abstract

This study rigorously investigates the flow dynamics of hybrid nanofluids comprising Cu + Al2O3 nanoparticles in Ethylene Glycol around a cylindrical shape. The analysis incorporates advanced concepts such as non-Newtonian power law behavior, viscous dissipation, the Cattaneo-Christov heat flux model, porous medium effects, the Hall effect, and Magnetic field influence. Utilizing similarity transformations, the non-linear PDEs are transformed into non-linear ODEs which are solved numerically using Runge-Kutta-Fehlberg with shooting technique coding in Python. The effects of various thermo-physical and geometrical parameters on the non-dimensional velocity f '(η), transverse velocity h(η), and temperature θ(η) profiles are meticulously analyzed through graphical representations and numerical data. Results demonstrate a significant reduction in fluid velocity f '(η) components and increasing in transverse velocity profile h(η) with increasing magnetic field strength M. Additionally, variations in the thermal relaxation parameter 𝛤 result in substantial changes in the Nusselt number 𝑁𝑢𝑥, indicating enhanced heat transfer rates. Additionally, the study finds that changes in the thermal relaxation parameter 𝛤 impact the Biot number Bi, diminishing its effect. The detailed impacts of other parameters are discussed extensively in the study. These findings provide valuable insights for industrial applications, particularly in developing advanced cooling fluids for automotive and rocket engines. Enhanced heat dissipation and efficient thermal management are crucial for improving engine performance, reliability, and lifespan in these high-demand applications.
The impact of routine angiographic follow-up on 3-year clinical outcomes in older patients following percutaneous coronary intervention with drug-eluting stents
Authors: Hu Su-Tao , Shao Xian , Rha Seung-Woon , Zhang Jing-Kun , Wu Xue , Liu Xing , Hyun Su Jin , Cha Jin Ah , Choi Se Yeon , Park Soohyung , Choi Cheol Ung , Oh Dong Joo , Choi Byoung Geol , Chen Kang-Yin 
Published: October 2024

Abstract

Objectives
This study aimed to investigate the impact of routine angiographic follow-up (RAF) on 3-year clinical outcomes in older patients (≥ 65 years) following percutaneous coronary intervention (PCI) with drug-eluting stents (DES) as compared with those of patients with clinical follow-up (CF).
Methods
This study enrolled a total of 3,147 patients aged 65 years and older, who had undergone PCI with DES. Among these patients, 1,313 (%) underwent RAF at 6–9 months post - PCI, while the remaining 1,834 patients were clinically followed. To address baseline clinical and angiographic differences between the two groups, propensity score matching (PSM) analysis was performed. The primary endpoint was major adverse cardiac events (MACE), which include cardiac death (CD), non-fatal myocardial infarction (MI), and target lesion revascularization (TLR). Additionally, we assessed the secondary endpoints that included CD, non-fatal MI, TLR, target vessel revascularization (TVR), non-target vessel revascularization (non - TVR), and stent thrombosis (ST).
Results
Following PSM, the 3-year cumulative incidence for TLR (hazard ratio [HR], 3.415; 95% confidence interval [CI], 2.120–5.500; p < 0.001), TVR (HR, 2.801; 95% CI, 1.890–4.151; p < 0.001), non-TVR (HR, 2.180; 95% CI, 1.413–3.364; p < 0.001) and MACE (HR, 2.383; 95% CI, 1.659–3.423, p < 0.001) were significantly higher in the RAF group. However, there were no significant differences observed in the incidence of CD, non-fatal MI, or ST between the two groups.
Conclusions
In older patients who underwent PCI with DES, RAF was associated with higher incidences of revascularization and MACE, despite of similar incidence of CD, non-fatal MI, or ST between the RAF and CF groups. These findings suggest that the implementation of the RAF strategy may not be necessary for older patients following PCI with DESs.
Brain and Systemic Oxygenation Coupling in Sleep-Disordered Breathing Tied to Cognition in Elderly
Authors: Kawai MAKOTO , Hosseini S.M. Hadi , Buck Casey , Karna Rosy , Parker-Fong Kai , Taweesedt Pahnwat 
Published: October 2024

Abstract

Background: Intermittent hypoxia, one of the consequences of sleep-disordered breathing (SDB), could contribute to an increased risk of cognitive decline. However, the association between SDB and cognition varies widely.
Methods: Fifty-two community-dwelling healthy older adults (28 women) without dementia were recruited. All participants underwent neuropsychiatric evaluations, simultaneous in-home polysomnography (PSG), and NIRS recordings. We quantified the average coherence between oxy-Hb and SpO2 signals during SDB events to see if it can predict cognitive outcomes in healthy older adults, where higher coherence represents less protection against systemic hypoxia.
Results: The mean (SD) coherence of oxy-Hb and SpO2 was 0.16 (0.07). Linear regression analysis showed a significant association between mean coherence and increased age and education-adjusted Stroop Color Word Test scores (t=-.304, p=.004). Whereas, oxy-Hb reduction alone did not show a significant association with cognition, and there were no significant correlations between conventional SDB parameters and cognition.
Conclusion: A higher coherence rate of cortical oxy-Hb and systemic SpO2 during SDB possibly reflects a loss of compensatory mechanism against systemic hypoxia and may help stratify older adults with a higher risk for cognitive decline. This is the first report on the association between NIRS parameters in SDB and cognition in older adults.
Hydatid Disease Contributes to Spinal Cord Compression: A Case Report and Literature Review
Authors: Cheng Jinchao , Ma Bing , Li Min , Zhao Kai , Li Haifeng , Bai Ruijun 
Published: October 2024

Abstract

Background
Hydatid disease is an infectious disease caused by echinococcus that causes liver and lung damage in humans. Bone involvement is rare and accounts for only 0.5%-4% of hydatid diseases; the spine is more prone to be infected with a proportion of 50% in musculoskeletal tissue. Missed hydatid cysts may lead to serious consequence, it is necessary to diagnosis and treatment of hydatid cysts at early stage.
Case presentation:
We present a case of a 47yearold Han Chinese male diagnosed with spinal hydatidosis. The patient lived in pasturing areas accompanied by symptoms of low back pain radiating to the legs, progressive weakness, and hypoesthesia in the lower limbs accompanied by difficulty walking. Computed tomography (CT) images showed a spinal hydatid cyst in the lumbar vertebra2 (L2) that caused bone destruction in the vertebral body and lamina. Magnetic resonance imaging (MRI) images showed hyperintense cystic components on L2 with the appearance of a lobulated, multiocular, septate cystic mass and compression of the spinal cord at the segments of L2. The patient underwent subtotal vertebral resection to completely remove the damaged vertebral and paravertebral cysts, and histopathological examination revealed the characteristic features of hydatid cysts. The patient received a postoperative antiparasitic drug treatment and finally achieved a successful treatment.
Conclusions
Spinal hydatidosis is a rare infectious disease. It should be considered as an important differential diagnosis for patients accompanying by spinal bone destruction with animal contact history. Surgical removal combined with antiviral drugs is an effective way to treat spinal hydatidosis. In addition, long term follow-up is mandatory for avoiding its recurrence.
Correlates of sleep variability in a mobile EEG-based volunteer study
Authors: Ujma Péter Przemyslaw , Bódizs Róbert 
Published: October 2024

Abstract

Variable sleep patterns are a risk factor for disease, but the reasons some people express greater within-individual variability of sleep characteristics remains poorly understood. In our study, we leverage BSETS, a novel mobile EEG-based dataset in which 1901 nights in total were recorded from 267 extensively phenotyped participants to identify factors related to demographics, mental health, personality, chronotype and sleep characteristics which predict variability in sleep, including detailed sleep macrostructure metrics. Young age, late chronotype, and napping emerged as robust correlates of increased sleep variability. Correlations with other characteristics (such as student status, personality, mental health and co-sleeping) generally disappeared after controlling for age. We critically examine the utility of controlling the correlates of sleep variability for the means of sleep variables. Our research shows that age and sleep habits affecting the amount of sleep pressure at night are the most important factors underlying sleep variability, with a smaller role of other psychosocial variables. The avoidance of daytime naps emerges as the most promising modifiable behavior associated with increased sleep regularity.
Beyond the Bite: Exploring Mental Health of Dental Faculty – A Multi-institutional Study
Authors: Ali Kamran , Zahra Daniel , Bashir Ulfat , Daud Alaa , Raja Hina , Witton Robert , Raja Mahwish 
Published: October 2024

Abstract

Introduction: Mental health issues are being reported increasingly amongst healthcare staff and students globally. The aim of this study was to investigate the frequency of common mental health issues amongst dental faculty members at multiple institutions in a developing country
Methods: Following approval from the institutional ethics review board, dental faculty members at 14 dental institutions were invited to participate in an online survey based on globally validated scales for mental health problems including the Patient Health Questionnaire (PHQ-9), and the Depression, Anxiety, and Stress Scale (DASS-21). Two open-ended questions were included in the survey to identify perceived factors contributing to poor mental health and recommendations for improving institutional support.
Results: A total of 200 faculty members provided their responses to the survey questionnaire but complete responses were provided by 183 participants which included 120 (65.57%) females, and 63 (34.43%) males. The overall response rate was 43%. Most participants were in the 31-40 years age-group (n=81, 44.26%) followed by 25-30 year (n=51, 22.87%) and 41-50 years (n=40, 21.86%). The mean score on PHQ-9 was 6.51 (SD ± 5.4) while the mean DASS-21 score was 13.04 (SD ± 10.95). PHQ-9 Depression, and DASS-21 Depression, Anxiety, and Stress scores were all significantly positively correlated for the whole sample, and within each subgroup of each demographic factor. Job-related workload, lack of institutional support, financial limitations, and poor work life balance were identified as the main factors contributing adversely to the mental health of the participants.
Discussion: This study provides useful insights into the scale of mental health status amongst dental faculty members from 14 institutions. Underlying factors affecting the mental health of faculty members adversely were identified and recommendations are provided to address these challenges.
What Blocked Visual Stimuli in Art brings to Emotional Expression
Authors: Ma Yuan , Xu Ting , Wang Yu 
Published: October 2024

Abstract

Blindness is often defined as a sensory state with negative implications. However, this may be an uncertain conclusion. There has been a longstanding and fundamental debate about how emotions are conveyed through art. Some artists and theorists argue that visual features like color, line, form, and composition consistently express various emotions, while others believe that non-visual senses resonate more with the audience, conveying a stronger emotional connection. This article is inspired by blindness and explores how vision-able participants discover the potentiality of participatory creative process while blindfolded and without visual stimuli. In this case study, revolving around an experiment with blindfolded creative participants at the sensory arts festival, and used to analyze the non-visual characteristics of potential emotional expression by using interpretive phenomenological analysis (IPA). Authors found that evidence of consistency in emotional ratings by participants in the art practice process perceived under the visual blocked. Overall, the authors’ results reveal enhanced use and sensitivity of non-visual senses when visual stimuli are blocked, indicating a strong bottom-up and subjective expression of emotions. Scenario enactment offers a different perspective on artistic creation and its emotional value, tapping into fundamental non-visual mechanisms.
Mechanism and Origins of Selectivity for [Ga4L6]12- -Catalyzed SN2 Reaction with Benzylic Ether and Methanol: A Computational Mechanistic Study
Authors: Zhang Zhengxu , Sun Zehua 
Published: October 2024

Abstract

Supramolecular catalysis often considered as the mimic of enzymatic catalysis, exhibits the properties of high reactivity and selectivity with various transformations. Bergman demonstrated that the reaction of chiral benzylic ester and methanol with Brønsted acid catalyst in bulk solution proceeded through an SN2 mechanism and generate chirality-inversed product, while when the reaction occurred with the supramolecular [Ga4L6]12- catalyst it formed the chirality-retained product. The detailed reaction mechanism as well as the origins of selectivity remains unclear. Therefore, in this work we have performed a comprehensive theoretical study on the nucleophilic substitution reaction catalyzed by both Brønsted acid and [Ga4L6]12- catalyst. Our calculations are in agreement with experiment. Detailed analyses indicate that compared to that of a classical SN2 reaction in bulk solution, after the encapsulation of the reactants in [Ga4L6]12-, the same-side nucleophilic attack of the methanol with the leaving group is more favorable than the back-side attack, which is due to more favorable hydrogen bonding interactions and π-π stacking interaction between the reactants and the supramolecular cage. Understanding the mechanism and origins of the stereochemical outcome in the nucleophilic substitution reaction with the supramolecular host-guest catalysis would lead to the development of more efficient and selective transformations.
Development and iterative optimization of an independently usable assistance system to assess, maintain and improve the nutritional and mobility status of older adults: an iterative usability study
Authors: Förster Mareike , Happe Lisa , Quinten Vincent , Diekmann Rebecca 
Published: October 2024

Abstract

Background
Promoting a balanced diet and regular physical activity is crucial for maintaining independence in old age. Technical assistance systems can help identify nutritional and mobility deficits and initiate appropriate interventions. We are developing a technical assistance system consisting of a measurement and training station and a tablet-based app (AS-Tra). AS-Tra is specifically designed for independent use by participants aged ≥ 70 years to assess and improve their nutritional and mobility status.
Objective
This study aimed to identify optimization potentials of the AS-Tra system together with members of the target group through iterative test cycles until good usability is achieved.
Methods
The system is developed as a complex intervention in accordance with the MRC framework and assessed in three iterative cycles for its usability. In each cycle, participants carried out structured predefined tasks. To capture their cognitive process, they were asked to ‘think aloud’. These thoughts were recorded with the necessary support for completing each task. Usability was measured using the System Usability Scale (SUS). Improvements based on the results were made. In the third cycle, independent use was simulated by leaving the participants alone in the lab, receiving tasks via audio instructions and observing them via webcams and eye-tracking glasses.
Results
A total of 34 participants (78.60 ± 5.59 years, 70.93% female) were included in the three iterative cycles (C1–C3). The SUS score improved from 70.63 to 84.55 between C1 and C2 and decreased slightly to 78.18 at C3. Overall 63.11% of the tasks (n = 385) were completed without support. In 14.92% (n = 91) of all tasks, the task could be completed by repeating or rephrasing instructions, 20.33% (n = 124) with direct reference to the solution, and 1.15% (n = 7) of all tasks could not be completed independently.
Conclusions
The results of the cycles enabled us to develop an independently usable system for assessing the nutritional and mobility situations of older people with good usability. Additionally, the relevance of support functions and the importance of research under real conditions became clear.
Trial registration number:
German Clinical Trials Register (DRKS), DRKS00031719, registered May 2023, https://drks.de/search/de/trial/DRKS00031719