bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of knowledge and attitude concerning augmented renal clearance among physicians and clinical pharmacists in Al-Ain, UAE: A cross-sectional study
Authors: Alshouli Betoul , Abbas Maram O. , Alsharji Raniah , Jaber Ammar Ali Saleh 
Published: September 2024

Background
Kidney function assessment is crucial in critical illness patients and is required before administering renally excreted medication, especially antibiotics and antiepileptics. Conventional clinical practice often focuses on renal impairment with low creatinine clearance (CrCl) and overlooks the augmented renal clearance (ARC), which is defined by (CrCl) more than 130 ml/min. This typical demonstration neglects individuals who experience hyperfunctioning kidneys. Among critically ill patients, the prevalence of (ARC) is approximately 20% to 65% of cases. This study aims to evaluate physicians’ and clinical pharmacists’ knowledge about ARC-associated risk factors, antibiotic regimen modification in ARC patients, and attitudes towards ARC workshops and guidelines in Al-Ain, UAE.

Methods
A cross-sectional, online self-administered survey-based study was designed to achieve this study’s aim. The questionnaire was constructed on profound literature analysis, validated, and piloted. The survey was emailed to physicians and pharmacists working in two hospitals, private and governmental, and distributed through different social media platforms over three months, December 2022—February 2023.

Results
Of the 92 complete responses (32 clinical pharmacists, 60 physicians), 57 (61.9%), were aware of ARC, but 72 (78%) demonstrated poor knowledge overall. Clinical pharmacists had a higher mean rank of knowledge than the physician’s group. Meanwhile, 70 (76.1%) participants were unaware of the eGFR threshold to determine ARC. There is a noticeable positive attitude toward seeking more information about antibiotic dose adjustment in ARC patients at 85 (92%) of the respondents. Remarkably, only 28 (30.4%) were directly involved with ARC patients’ treatment plans.

Conclusion
In conclusion, clinical pharmacists showed better knowledge than physicians. However, overall, the participating healthcare providers lacked knowledge about ARC, so a reliable source of information regarding ARC should be utilized. Future research could explore the implementation of professional development workshops for healthcare providers and national guidelines and then assess their impact on patient outcomes.
Distribution of MRI-derived T2 values as a biomarker for in vivo rapid screening of phenotype severity in mdx mice
Authors: Waters Emily A. , Haney Chad R. , Vaught Lauren A , McNally Elizabeth M. , Demonbreun Alexis R. 
Published: September 2024

Background
The pathology in Duchenne muscular dystrophy (DMD) is characterized by degenerating muscle fibers, inflammation, fibro-fatty infiltrate, and edema, and these pathological processes replace normal healthy muscle tissue. The mdx mouse model is one of the most commonly used preclinical models to study DMD. Mounting evidence has emerged illustrating that muscle disease progression varies considerably in mdx mice, with inter-animal differences as well as intra-muscular differences in pathology in individual mdx mice. This variation is important to consider when conducting assessments of drug efficacy and in longitudinal studies. We developed a magnetic resonance imaging (MRI) segmentation and analysis pipeline to rapidly and non-invasively measure the severity of muscle disease in mdx mice.

Methods
Wildtype and mdx mice were imaged with MRI and T2 maps were obtained axially across the hindlimbs. A neural network was trained to rapidly and semi-automatically segment the muscle tissue, and the distribution of resulting T2 values was analyzed. Interdecile range and Pearson Skew were identified as biomarkers to quickly and accurately estimate muscle disease severity in mice.

Results
The semiautomated segmentation tool reduced image processing time approximately tenfold. Measures of Pearson skew and interdecile range based on that segmentation were repeatable and reflected muscle disease severity in healthy wildtype and diseased mdx mice based on both qualitative observation of images and correlation with Evans blue dye uptake.

Conclusion
Use of this rapid, non-invasive, semi-automated MR image segmentation and analysis pipeline has the potential to transform preclinical studies, allowing for pre-screening of dystrophic mice prior to study enrollment to ensure more uniform muscle disease pathology across treatment groups, improving study outcomes.
Interventions to enhance mental health and wellbeing among international college students: A systematic review and meta-analysis protocol
Authors: Liu Cheng-Ching , Huang Qi , Chen Angela Chia-Chen , Liu Charles , Liu Yuqing 
Published: September 2024

Background
International students contribute significantly to both the economy and the intellectual and cultural landscape of host countries. Their interactions with domestic students foster personal, socioeconomic, and political development, promopting a broader understanding of diverse cultures and values. This highlights how crucial international education is for staying competitive globally. However, international students often face challenges such as poor mental health, linguistic and cultural barriers, acculturative stress, and limited health literacy. Therefore, supporting their academic success and well-being on college campuses is essential. This protocol aims to describe strategies used to evaluate the effect of interventions on international students’ mental health and wellbeing and propose directions for future research based on the evidence.

Methods
We will conduct an extensive search in several databases including CINAHL, PubMed, Web of Science, PsyInFO, ERIC, and Google Scholar with no date limits. Two reviewers will independently screen the literature and extract data. We will then conduct meta-analyses of the extracted data.

Discussion
To the best of our knowledge, this study is the first systematic review with meta-analysis focusing on interventions to enhance mental health and wellbeing among international college students. This study will provide most updated empirical evidence on the effects of interventions aimed to improve international students’ mental health and wellbeing. The findings from this study will summarize the importance of a range of interventions being available to international students who experience psychological distress and the effectiveness of each intervention. This study will also highlight the gap for researchers to focus on for future studies.

Trial registration
PROSPERO registration number: CRD42024528767.
Expectations of healthcare professionals of community-based telemedicine in emergency medical service
Authors: Klager Elisabeth , Teufel Anna , Eitenberger Magdalena , Bukowski Nils , Lintschinger Josef Michael , Manschein Valerie , Metelka Philipp , Willschke Harald , Schaden Eva , Frimmel Christoph , Renner Reinhold , Hafner Christina 
Published: September 2024

Background
In times of demographic change and an immense shortage of qualified personnel in emergency medical services, telemedicine could offer more efficient solutions for better care. Given the community-based nature of emergency services, local communities play an important role. This study explored the expectations of healthcare professionals and volunteers for telemedicine tools in prehospital emergency medicine.

Methods
This mixed-methods study was conducted in the rural region of Burgenland in Austria with stakeholders of the local emergency medical service in two focus groups (13 participants) and 99 quantitative questionnaires.

Results
Combining quantitative and qualitative data, we found that a majority of respondents (almost 80%) already experienced basic telemedicine and consider it valuable. In particular, there is a strong expectation for diagnostic support and inquiries related to potential hospitalization. Findings from two focus groups emphasized the importance of cultivating an improved learning culture, developing a specific mindset, and refining soft skills. The optimal telemedicine solution includes a knowledgeable and experienced tele-emergency physician coupled with user-friendly technology.

Conclusion
To be clear about the expectations of stakeholders, it is essential to involve all stakeholders right from the beginning. The solution should prioritize the integration of existing structures and be seamlessly incorporated into an evolving learning culture, while also fostering the necessary mindsets alongside educational aspects.
KONSEP FELIX SIAUW TENTANG TAARUF ANTARA CALON MEMPELAI PRIA DAN CALON MEMPELAI WANITA
Authors: Hakim Robith Muti’ul 
Published: September 2024

Normatively, before there marriage hold certain processes that will be undertaken of a man and women, including: process ta’aruf, khitbah, followed by the ceremony. Felix Siauw has another opinion about the sequence of theprocesses that are undertaken before marriage. He argues that the process of ta’aruf khitbah precedence, so khitbah first and then ta’a>ruf. He reasoned that the majority of young people who want to get a potential partner in the present more follow it with the first courtship. The majority reasoned that premarital courtship as a venue for exploration, to better get to know each other’s personalities. It is considered to be vulnerable to various immoral acts by him, and therefore he would prefer putting khitbah than ta’a>ruf, in addition to that he also has some concepts in ta’aruf. Ustad Felix Siauw have a concept in ta’aruf. This paper will explain the concept Felix Siauw in terms of Mas}ah}lah and Maqa>s}id asy-Syari>’ah.[Secara normatif, sebelum melangsungkan perkawinan terdapat proses-proses tertentu yang akan dijalani seorang pria maupun wanita, diantaranya: proses ta’aruf, khitbah, dilanjutkan dengan akad nikah. Felix Siauw memiliki pendapat yang lain mengenai urutan proses-proses yang dijalani sebelum perkawinan. Beliau berpendapat bahwa proses khitbah lebih didahulukan dari ta’aruf, jadi khitbah terlebih dahulu baru kemudian ta’a>ruf. Beliau beralasan bahwa mayoritas pemuda-pemudi yang ingin mendapatkan calon pasangan pada masa kini lebih menempuhnya dengan jalan pacaran terlebih dahulu. Sebagian beralasan bahwa pacaran sebagai ajang penjajakan pranikah, agar lebih bisa mengenal kepribadian masing-masing. Hal tersebut dianggap rentan terhadap berbagai perbuatan maksiat oleh beliau, maka beliau lebih memilih mendahulukan khitbah dibanding ta’a>ruf, selain itu beliau juga mempunyai beberapa konsep dalam ta’aruf. Tulisan ini akan mengkaji pemikiran Felix Siauwdilihat dari sisi Mas}lah}ah dan Maqa>s{id asy-Syari<’ah].
An overview of the role of nanoherbicides in tackling challenges of weed management in wheat: A novel approach
Authors: Khan Bilal Ahmad , Nadeem Muhammad Ather , Najeeb Alawadi Hussam F. , Ayub Muhammad Ashar , Mahmood Athar , Abbas Tasawer , Nijabat Aneela , Ameen Muaz , Abdullah FNU , Oraby Hesham , Elnaggar Nehal 
Published: September 2024

Abstract
One of the most significant biotic constraints that wheat production faces is weed infestation. Wheat is infested with different weeds that cause yield losses (up to 100%) that vary based on the type of weed, their density, and the environmental conditions. Chemical weed control is the most common method to control weeds in wheat. However, widespread herbicide resistance (>365 cases worldwide) has challenged the sustainability of this method. Use of nanoherbicides is a promising strategy to cope with the issue of herbicide resistance. To achieve weed control conditions during the whole growing season, nanoformulations of herbicides are a delivery strategy that involves covering an active component with various materials that vary in size from nano to nanoscale and then releasing the substance in a controlled manner. Nanoherbicides prevent leaching and volatilization of active components and premature degradation through photolysis, hydrolysis, and biodegradation. According to studies, nanoencapsulation of herbicides produces more targeted and less hazardous agricultural formulations. Using nanoherbicides in lower concentrations is beneficial. It lessens the long-term impacts of herbicide residues in wheat fields and the toxicity of these herbicides to the environment. It is also beneficial in eliminating the weeds without ever interacting with the crop plants, which eventually results in a greater wheat yield. This review provides a comprehensive overview of the emerging field of utilizing nanoparticles (NPs) in herbicides for effective weed management in wheat crops. This article explores the novel approach of integrating NPs with herbicidal agents, highlighting their potential benefits and challenges. The review also addresses the current state of research, recent advancements, and potential future directions in this evolving area of agricultural science.
Effects of thyroid hormones in skeletal muscle protein turnover
Authors: Nappi Annarita , Moriello Caterina , Morgante Maria , Fusco Ferdinando , Crocetto Felice , Miro Caterina 
Published: September 2024

Abstract
Thyroid hormones (THs) are critical regulators of muscle metabolism in both healthy and unhealthy conditions. Acting concurrently as powerful anabolic and catabolic factors, THs are endowed with a vital role in muscle mass maintenance. As a result, thyroid dysfunctions are the leading cause of a wide range of muscle pathologies, globally identified as myopathies. Whether muscle wasting is a common feature in patients with hyperthyroidism and is mainly caused by THs-dependent stimulation of muscle proteolysis, also muscle growth is often associated with hyperthyroid conditions, linked to THs-dependent stimulation of muscle protein synthesis. Noteworthy, also hypothyroid status negatively impacts on muscle physiology, causing muscle weakness and fatigue. Most of these symptoms are due to altered balance between muscle protein synthesis and breakdown. Thus, a comprehensive understanding of THs-dependent skeletal muscle protein turnover might facilitate the management of physical discomfort or weakness in conditions of thyroid disease.
Herein, we describe the molecular mechanisms underlying the THs-dependent alteration of skeletal muscle structure and function associated with muscle atrophy and hypertrophy, thus providing new insights for targeted modulation of skeletal muscle dynamics.
Ureteral access sheaths in RIRS: a retrospective, comparative, single-center study
Authors: Celentano Giuseppe , Barone Biagio , La Rocca Roberto , Massanova Matteo , Napolitano Luigi , Prezioso Domenico , Abate Marco , Mirto Benito Fabio , Fusco Ferdinando , Crocetto Felice 
Published: September 2024

Abstract

Objectives
To evaluate the use of ureteral access sheaths (UAS) in reducing operative time and complications, as well as improving stone-free rates (SFR), while assessing their overall safety and efficiency.

Methods
Data regarding 234 patients who underwent retrograde intrarenal surgery (RIRS) for stones up to 3 cm between January 2017 and March 2020 were retrospectively analyzed. About 52.5 % of procedures were performed utilizing a UAS. Differences in operative time, fluoroscopy time, stone-free rate, and complications were analyzed between procedures with and without UAS and stratified, according to stone burden size, into three groups (Group A: 0.5–1 cm; Group B: 1–2 cm; Group C: 2–3 cm).

Results
Operative time, fluoroscopy time, and residual fragments size were lower in RIRS without UAS, respectively, 54.27 ± 24.02 vs. 62.23 ± 22.66 min (p=0.010), 2.72 ± 0.89 vs. 4.44 ± 1.67 min (p<0.0001), and 3.85 ± 0.813 vs. 4.60 ± 0.83 mm (p=0.011). Considering stone burden, operative time was lower in RIRS without UAS for Group A (36.40 ± 8.555 vs. 46.05 ± 6.332 min) (p<0.0001) while higher for Group B (60.39 ± 18.785 vs. 50.14 ± 5.812 min) (p=0.002). Similarly, fluoroscopy time was lower in RIRS without UAS in every group, respectively, 2.11 ± 0.34 vs. 2.74 ± 0.57 min (p<0.0001), 2.94 ± 0.51 vs. 4.72 ± 0.37 min (p<0.0001), and 3.78 ± 1.26 vs. 6.79 ± 1.17 min (p<0.0001). Only Group C had a statistically significant difference in residual fragment size without UAS (3.89 ± 0.782 vs. 4.75 ± 0.886 mm) (p=0.050).

Conclusions
UAS should be carefully evaluated considering the increased fluoroscopy time and the differences in operative time related to different stone burdens.
Higher-order nonlocal multipoint q-integral boundary value problems for fractional q-difference equations with dual hybrid terms
Authors: Alsaedi Ahmed , Alharbi Boshra , Ahmad Bashir 
Published: September 2024

Abstract
In this article, we introduce and study a new class of higher-order fractional q-difference equations involving Riemann-Liouville q-derivatives with dual hybrid terms, supplemented with nonlocal multipoint q-integral boundary conditions. The existence of a unique solution to the given problem is shown by applying Banach’s fixed point theorem. We also present existing criteria for solutions to the problem at hand with the aid of Krasnoselskii’s fixed point theorem and Leray-Schauder’s nonlinear alternative. Illustrative examples are given to demonstrate the application of the obtained results.
Noetherian rings of composite generalized power series
Authors: Oh Dong Yeol 
Published: September 2024

Abstract
Let

A
⊆
B

A\subseteq B

be an extension of commutative rings with identity,

(

S
,
≤

)

\left(S,\le )

a nonzero strictly ordered monoid, and

S

*

=
S
\

{

0

}

{S}^{* }\left=S\backslash \left\{0\right\}

. Let

A
+
〚

B

S

*

,
≤

〛
=

{

f
∈
〚

B

S
,
≤

〛

∣

f

(

0

)

∈
A

}

A+[\kern-2pt[ {B}^{{S}^{* },\le }]\kern-2pt] =\{f\in [\kern-2pt[ {B}^{S,\le }]\kern-2pt] \hspace{0.33em}| \hspace{0.33em}f\left(0)\in A\}

. In this study, we determine when the ring

A
+
〚

B

S

*

,
≤

〛

A+[\kern-2pt[ {B}^{{S}^{* },\le }]\kern-2pt]

is a Noetherian ring. We prove that when

S

S

is a strict monoid, if

A
+
〚

B

S

*

,
≤

〛

A+[\kern-2pt[ {B}^{{S}^{* },\le }]\kern-2pt]

is a Noetherian ring, then

A

A

is a Noetherian ring,

B

B

is a finitely generated

A

A

-module, and

S

S

is finitely generated. We also show that if

B

B

is a finitely generated

A

A

-module over a Noetherian ring

A

A

and

(

S
,
≤

)

\left(S,\le )

is a positive strictly ordered monoid, which is finitely generated, then

A
+
〚

B

S

*

,
≤

〛

A+[\kern-2pt[ {B}^{{S}^{* },\le }]\kern-2pt]

is a Noetherian ring.
Hambatan dan tantangan pembelajaran Ilmu Pengetahuan Sosial di sekolah dasar
Authors: Lestari Madya Indah 
Published: September 2024

Pembelajaran ilmu pengetahuan sosial (IPS) disekolah dasar menghadapi berbagai hambatan dan tantangan,baik yang bersifat internal maupun eksternal. Tujuan dari penelitian ini adalah untuk mengidentifikasi hambatan dan tantangan dalam pembelajaran IPS serta mengusulkan strategi untuk mengatasi tantangan tersebut dalam konteks era revolusi 4.0.metode penelitian yang diterapkan adalah kualitatif dengan mengunakan diskusi mendalam dan observasi sebagai teknik pengumpulan data. penelitian menunjukan bahwa hambatan utama adalah faktor internal seperti kebosan siswa, kurang termotivasi dengan materi pembelajaran yang luas serta faktor eksternal seperti kurangnya keberagaman metode pembelajaran. Tantangan diera revolusi industri 4.0 antara lain penyesuaian kurikulum dan peningkatan kualitas guru, startegi yang dapat di gunakan guru adalah integrasi teknologi dalam pembelajaran, pengembangan keterampilan siswa dan peningkatan profesionalitas guru.
L' étude de la sociologie-micro de Georg Simmel sur le roman Un Prête Marié de Jules Barbey d’Aurevilly
Authors: Fraditha Josephany Eva , Kurniawati Novi , Sunahrowi Sunahrowi , Yulianto Ahmad 
Published: September 2024

Le roman Un prêtre marié montre les problèmes de relations interindividuelles entre Jean Sombreval qui est un ex-prêtre athée et les gens conservateur. Lui et sa fille ont dû faire face à la discrimination de la société à cause de son apostasie. Le but de cette étude est de décrire les formes de conscience individuelle et d'interaction sociale des personnages, ainsi que de décrire la forme de structure sociale de la société et de la culture objective telle que dépeinte dans le roman Un Prêtre Marié. La méthode de recherche utilisée est l'analyse descriptive. L'objet matériel de cette étude est le roman Un prêtre marié, utilisant l'approche de la micro sociologie de Georg Simmel. Les résultats de cette étude sont les manifestations de la conscience individuelle des personnages à partir des activités de sensibilisation qu'ils mènent, les formes des interactions sociales des personnages basées sur la forme, le type et l'interaction des groupes dyade-triade, la structure sociale et la culture objective qui sont dépeintes dans le roman Un prêtre marié. À partir de l'analyse des quatre principaux concepts de sociologie-micro sur le roman d'Un prêtre marié, on peut conclure qu'une différence dans une société homogène entraîne des problèmes d'interaction sociale. Cela peut arriver parce que la conscience de chaque individu qui ne reconnaît pas une différence due à la vie sociale et culturelle qui les domine ne reflète pas la diversité individuelle.
Les actes de langage d’illocution directives dans la bande-dessinée Les Nouvelles Aventures de Lucky Luke Dalton City
Authors: Lathifa Avia Rahmatul , Urip Sri Rejeki , Arsiyana Marliza , Pudjitriherwanti Anastasia 
Published: September 2024

Les actes de langage illocution a divisé en cinq types, entre sont les actes de langage directive. Cette recherche a pour objectif de décrire les types et les formes des actes de langage directive. L’objet de cette recherche est la bande dessinée Les Nouvelles Aventures de Lucky Luke Dalton City. La méthode utilisée la méthode lire (simak). Cette méthode est faite en utilisant la technique de taraudage de langue (sadap), la technique non participé à la conversation réelle (SBLC) et la technique (catat). La méthode d’appariement pragmatique (metode padan pragmatis) pour analyser les données. Dans ce cas la chercheuse utilise la technique de base la technique divisé des éléments différencier (PUP), la technique avancée de la technique de relier- comparer-égaliser (Hubung Banding Menyamakan). Les résultats de l'analyse, les types d'acte de langage directive peuvent être classés en: 1) demandé (15 données), 2) interdiction (9 données), 3) conseil (8 données), 4) exigé (19 données), 5) permissif (8 données). Les formes des actes de langage peut être classée en: 1) l'actes de langage direct (40 données), 2) l'actes de langage indirect (3 données), 3) l'actes de langage littéral (13 donnée), 4) l'actes de langage non-littéral (3 données).