bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beijing Central Asian Outbreak strain cluster of Mycobacterium tuberculosis detected in Irkutsk region, Russia
Authors: Zhdanova S. N. , Kondratov I. G. , Ogarkov O. V. 
Published: September 2024

Background. Irkutsk region maintains a high incidence rate of multidrug-resistant (MDR) tuberculosis (TB). Detection of MDR-associated Mycobacterium tuberculosis strains in Irkutsk region requires dynamic assessment of the TB pathogen population, taking into account the emergence of a new resistant variant of Beijing Central Asian Outbreak (CAO).The aim of the study. To assess changes in the genotypic structure of M. tuberculosis strains circulating in the Irkutsk region over a ten-year period.Materials and methods. A total of 732 M. tuberculosis strains (196 strains for 2021– 2022, 536 strains for 2011–2015) were studied using MIRU-VNTR and SNP typing.Results. The MDR level increased to 67.4 % with an increase of pre-extensive drug resistance (pre-XDR) (33.2 %) (p < 0.001). In the modern sample, the dominance of the Beijing genotype increased (83.7 %) due to an increase in the proportions of the B0/W148 (38.8 %) and CAO (12.8 %) subtypes with a stable overall level of Central Asian Russian (36.8 %) and other Beijing strains (8.2 %). Strains other than the Beijing genotype belonged mainly to the Euro-American lineage (Lineage 4): LAM (8.9 %), Ural (2.7 %), Haarlem (2.0 %), S (0.5 %) and L4-unclassified (5.3 %); 25 isolates were not classified. In the 2011–2015 sample, LAM was more common than in the modern sample (10.8 % vs. 3.6 %; p < 0.01). The increase in MDR and preXDR was statistically significant among Beijing B0/W148 strains (93.4 % vs. 66.1 %; p < 0.001).Conclusion. Unfavorable trends of significant spread of MDR and pre-XDR of the Beijing genotype strains were revealed. Among the Beijing strains, not only B0/W148 but also the Beijing CAO subtype, which was previously rare in Siberia, are the most successful; they have the highest levels of MDR and pre-XDR and a tendency to widespread distribution in all groups of TB patients.
Changes in the level of immune checkpoints in patients with various forms of autoimmune thyroiditis
Authors: Babinsky V. V. 
Published: September 2024

Background. Autoimmune thyroiditis (AIT) affects more than 5 % of the world’s population.The aim. To determine the level of sPD-1, sPD-L1, sCTLA-4 and sB7.2 molecules in individuals suffering from various forms of autoimmune thyroiditis.Methods. The study included 31 individuals aged 18 to 40 years. They were divided into four groups: group I – healthy individuals (n = 10); group II – carriers of antibodies to thyroid peroxidase (n = 11); group III – individuals with AIT accompanied with subclinical form of hypothyroidism (n = 6); group IV – individuals with AIT complicated by compensated hypothyroidism (n = 4). Venous blood was collected to determine the level of antibodies to thyroid peroxidase using enzyme immunoassay, the concentration of thyroid stimulating hormone and free thyroxine – using chemiluminescence immunoassay, and the levels of sPD-1, sPD-1L, sCTLA-4, and sB7.2 – using flow cytofluorometry. Statistical processing was performed using the Kruskal – Wallis one-way analysis of variance.Results. When comparing the level of sPD-1L in groups I (54.1 (28.7; 67.6) pg/ml) and II (4.36 (2.36; 18.0) pg/ml), the decreased in this indicator was 91.94 % (p = 0.001). When comparing the sPD-1 level in the group of healthy individuals (16.6 (13.6; 37.2) pg/ml) and group IV (7.28 (5.18; 11.1) pg/ml), werecorded a decrease of 56.14 % (p = 0.001). The sB7.2 concentration decreased by 65.03 % in group II (16.4 (15.6; 32.7) pg/ml) compared to the control group (46.9 (39.3; 54.4) pg/ml) (p = 0.001). In group III, the sCTLA-4 level was 3.22 (3.06; 3.33) pg/ml and decreased by 88.66% compared to the control group (p = 0.001).Conclusion. The development of autoimmune thyroiditis is accompanied with the decrease in the concentration of sPD-1, sPD-1L, sCTLA-4 and sB7.2.
Pathogenesis of respiratory failure in COVID-19 due to coagulopathy and endothelial dysfunction
Authors: Burdienko T. O. 
Published: September 2024

Respiratory failure is known to be the main clinical manifestation of COVID-19. However, the mechanism of its development has not been sufficiently studied. The originality of the study is that for the first time, coagulation, fibrinolysis and endothelial dysfunction indicators were studied depending on the SpO2/FiO2 index in patients with COVID-19.The aim of the work. To assess the role of impaired activity of the blood coagulation system and the development of endothelial dysfunction in patients with COVID-19 in the pathogenesis of respiratory failure.Methods. The study included 134 patients infected with SARS-CoV-2 virus having varying severity of the clinical picture. They were divided into three groups according to the SpO2/FiO2 index. We determined the number of venous blood cells and studied the level of transferrin (TF), D-dimer, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in the blood serum.Results. The study revealed that the tissue factor content increased by 24 % in patients of the third group compared to the first. The PAI-1 level was high in the second group and significantly decreased in the third (p < 0.001). An increase in the D-dimer level was recorded in the second and third groups. The levels of ICAM-1 and VCAM-1 molecules increased significantly in the third group of patients (p = 0.021 and p = 0.028, respectively). A moderate positive correlation was found between the SpO2/FiO2 index and the VCAM-1 level (p < 0.001), a weak positive correlation with PAI-1 (p = 0.012), and a weak negative correlation with TF (p = 0.027).Conclusion. Respiratory failure in patients with COVID-19 is caused by disorders in the hemostasis and fibrinolysis systems, as evidenced by an increase in the level of tissue factor and D-dimer, “consumption” of tissue activator and plasminogen activator inhibitor. Developing endothelial dysfunction, accompanied by increased secretion of adhesion molecules, aggravates the pathogenesis of respiratory failure.
HUBUNGAN PENGETAHUAN AKSEPTOR KB TENTANG IUD DENGAN KEIKUTSERTAAN MENGGUNAKAN IUD DI PMB BDN. NI WAYAN SUSIANTI, S.S.T.KEB
Authors: Pasguniari Ni Kadek Mianti , Mastiningsih Putu , Yunita Udayani Ni Putu Mirah , Kusuma Putra Putu Wira 
Published: September 2024

Contraception is a method or tool used with the aim of preventing pregnancy. The decrease in the number of IUD family planning participants over the years can be caused by the participants' lack of knowledge about the advantages of IUD contraception. Knowledge of contraceptive devices is a consideration in determining the contraceptive method used. The quality of family planning services is seen in terms of the availability of health service personnel tools, the high cost of IUD services, and the existence of barriers from husband support in the use of IUD contraceptive devices. The purpose of this study is to determine the Relationship of Family Planning Acceptors' Knowledge About IUD With Participation in Using IUD at PMB Bdn. Ni Wayan Susianti, S.S.T.Keb.
This study uses a correlational analytic design with a cross-sectional approach. The sample selection in this study used purposive sampling technique. The sample for this study is 40 acceptors. Data were analyzed using Chi-square test analysis. The results of the analysis using the Chi-square test showed that from 40 respondents, a p-value of 0.001 was obtained. This result indicates that H0 is rejected and Ha is accepted, which means there is a significant relationship between the knowledge of family planning acceptors about IUD and participation in using IUD at PMB Bdn. Ni Wayan Susianti, S.S.T.Keb. Based on the results of this study, it is hoped that family planning acceptors will increase their knowledge about IUD with participation in using IUD.
Evaluation of Enterobius Vermicularis Infection in Primary School and Relationship with Nocturnal Enuresis
Authors: Abdul Hadi Hamzah Dhuha , Shamkhi Jaber Zainab , Hadi Raheem Huda 
Published: September 2024

Enterobiasis or pinworms infection is one of the most prevalent worms found in children worldwide . There was a possible association between certain infection and the propensity to develop nocturnal enuresis including intestinal helminthes infection. Prospective study included (100) randomly selected children aged range (6-12) years from both sex, have been acquired from primary schools in the center of Al-Kut city. The children were examined for E.vermicularis infection by microscopic examination .Total positivity rate of Enterobiasis among children from 6 -12 years was 14% & the number of positive sample were 14 out of 100 child examined .37 (16.2%) were males and 63 (12.6%) were females..Males had a slightly higher prevalence than females However, difference was non-Significance (NS) P>0.05. The results showed the highest prevalence (28.57 %)in the group age 6 years , while the lower infection rate was found in the group age 10-12 years (0%), The statistical analysis showed significant differences at the level of 0.05 between the age groups. E. vermicularis is one of the most common intestinal helminthes with nocturnal enuresis among children in Al-Kut city., there are no significant differences (NS) P>0.05 between males and females for Enterobius vermicularis infection and nocturnal enuresis.
Blues Traditions of Guitar Performance in Modern Scientific Idea
Authors: Qin ShengYang 
Published: September 2024

The relevance of the article. Blues has always been and is still one of the most popular areas of non-academic art in the period from the end of the XIX century. However, after the Second World War, the blues tradition began to be actively assimilated against the background of other stylistic trends and subcultures. In this regard, the interest of modern scientists in blues specificity, which has become an important component of many modern musical phenomena, not only increased, but also expanded the perspectives of research. Starting from the second half of the XX century, blues traditions gained rapid development due to the technical revolution in the field of guitar performance. The invention of the electric guitar directed performers to the formation of a new way of thinking, a new performance technique, and new ways of self-expression. Such directions as rhythm and blues, blues rock, rock and roll absorbed a whole array of blues traditions, which in combination with other trends of musical culture formed the image of modern non-classical guitar performance. These processes have not yet received proper scientific development, although the number of scientific publications on the blues is very extensive.
The purpose of the study is to form a systematic view of the modern historiography of blues guitar performance research.
The methodology. The main method is the source and textological analysis of existing publications; method of systematic analysis, which allows to classify existing sources according to their nature, direction and subject of study; a comparative method involved in comparing the views of different scientists on the same issues.
The results. Contemporary (starting from around 1980) scientific publications on blues traditions of guitar performance were analyzed. It was determined that a number of aspects of modern performance are in the initial stage of development, a significant number of works are devoted to the early stage of the development of blues, mostly the material of scientific research is not musical material, but interviews, historical essays, etc.
The scientific novelty. The leading scientific works of the late XX and early XIX centuries are systematized and characterized regarding blues guitar performance, the “white spots” in its study are outlined, the main directions of scientific research are determined.
The practical significance. The materials of the article can be used for the further study of issues of the development of the blues tradition of guitar performance, as well as in music history courses and disciplines taught to students of the pop and jazz specialty.
Conclusions. Several leading aspects of art-historical studies of the blues tradition in guitar performance are highlighted:
– historical and genetic;
– sociocultural;
– practical and technological.
An important conclusion is the definition of blues as a musical universal, which provides a certain way of thinking and its artistic reflection in music, not fixed exclusively in the purely blues direction of guitar art.
Pelaksanaan Pengabdian “Pelatihan PembuatanMedia Pembelajaran PAUD berbantuan Microsoft Word Dan PowerPoint Di TK Al-Hidayah Pambusuang Kab. Polewai Mandar”
Authors: Afifa  , Sitti Inaya Masrura  , Irmawati  , Lili Rahmawati  
Published: September 2024

Kegiatan pengabdian pelatihan penggunaan Microsoft Word dan PowerPoint ini bertujuan untuk: 1) meningkatkan pengetahuan guru TK Al-Hidayah Pambusuang tentang pentingnya pemanfaatan media pembelajaran khususnya penggunaan aplikasi PPT dalam proses pembelajaran; 2) melatih guru mengembangkan media pembelajaran interaktif dengan aplikasi; 3) meningkatakan kualitas pembelajaran dengan memanfaatkan media pembelajaran interaktif dalam proses pembelajaran. Kegiatan ini dilaksanakan pada tanggal 5 Juli 2024 di TK Al-Hidayah Pambusuang Kecamatan Balanipa, Kabupaten Polewali Mandar, Sulawesi Barat dengan guru TK sebagai peserta. Kegiatan ini terdiri dari tahap persiapan, tahap pelaksanaan, serta tahap akhir dan berlangsung dengan baik dan mencapai tujuan dengan memberikan kontribusi yang positif terhadap para peserta dalam pengembangan kompetensi sebagai guru.
ANALYSIS ОF THЕ VОLUMЕ ОF САPITAL INVЕSTMЕNTS ОF ЕNTЕRPRISЕS IN UKRAINЕ
Authors: Bondarіeva Tetiana , Nemkovych Oksana 
Published: September 2024

Thе article is dеvоtеd tо thе assessment оf thе invеstmеnt prосеss in Ukrainе. Fоr thе analysis, thе indiсatоr "vоlumе оf сapital invеstmеnts" was usеd, whiсh сharaсtеrizеs thе еxpеnsеs оf lеgal еntitiеs and individuals fоr thе aсquisitiоn, prоduсtiоn оr сrеatiоn оf tangiblе and intangiblе nоn-сurrеnt assеts. Aссоrding tо thе rеsults оf thе analysis оf thе vоlumе оf сapital invеstmеnts madе by Ukrainian еntеrprisеs in variоus typеs оf tangiblе and intangiblе assеts, it was еstablishеd that frоm 2014 tо 2019, thеir соnstant grоwth tооk plaсе with an avеragе grоwth ratе оf 24.3%. Hоwеvеr, thе nеgativе соnsеquеnсеs оf thе СОVID-19 pandеmiс and thе full-sсalе invasiоn оf thе Russian Fеdеratiоn intо Ukrainе lеd tо a sharp rеduсtiоn in thе vоlumе оf сapital invеstmеnts. Thе dynamiсs оf thе vоlumе and spесifiс wеight оf сapital invеstmеnts in thе sесtiоn оf largе, mеdium and small еntеrprisеs оf Ukrainе wеrе studiеd. It was еstablishеd that mеdium and small еntеrprisеsin thе prосеss оf dеvеlоping сapital invеstmеnts madе mоst оf thеm in maсhinеs and еquipmеnt, whilе largе еntеrprisеs invеstеd mоrе aсtivеly in thе соnstruсtiоn and rесоnstruсtiоn оf buildings. It is nоtеd that althоugh largе еntеrprisеs havе mоrе оppоrtunitiеs tо inсrеasе thе amоunt оf сapital invеstmеnt in thе purсhasе оf sоftwarе соmparеd tо mеdium and smallеntеrprisеs, it still rеmains at a lоw lеvеl, whiсh in 2022 dесrеasеd by 73% tо UAH 1.4 billiоn. It is arguеd that dеspitе thе diffiсult situatiоn in Ukrainе, tоday it is impоrtant tо inсrеasе thе vоlumе оf invеstmеnts in sоftwarе, whiсh is pоtеntially bеnеfiсial fоr all typеs оf еntеrprisеs, rеgardlеss оf sizе. It is rесоmmеndеd that Ukrainian businеssеs abandоn thе sоftwarе prоduсts оf thе aggrеssоr соuntry and makе сapital invеstmеnts in altеrnativе dоmеstiс оr intеrnatiоnal prоduсts, sinсе in any сasе Russian sоftwarе will bе bannеd оr will simply сеasе tо funсtiоn in Ukrainе.
HIV Epidemic among Pakistani Inhabitants in District Faisalabad, Pakistan
Authors: Yasmin Riffat , Raza Mesum , Asif Rizwan , Khalid Tehmina , Raza Syed Kashif , Kalsoom Furkhanda , Shaikh Maida 
Published: September 2024

The pandemic of HIV/AIDS has severely impacted the most vulnerable sections of society in Pakistan. The results of the current study on the HIV epidemiology in Faisalabad, Pakistan, highlighted the importance of preventive measures. The current study attempted to assess the prevalence of HIV in Faisalabad. Moreover, it also identified potential risk factors for the spread of this pandemic in the region. A total of 1540 test results were gathered between March 2020 and July 2022 from 3 hospitals, that is, Allied Hospital, Aziz Fatima, and DHQ Hospital Faisalabad. Immuno-chromatographic Technique (ICT) was used to detect the presence of the infection. The researchers in District Faisalabad, Pakistan, surveyed 1540 locals to determine the HIV prevalence in that area. About 33 cases of HIV infection were confirmed through ICT, with a prevalence rate of 2.14%. Roughly, 25 males, however, only 8 females tested positive for HIV. Since more than half of HIV diagnoses occur in people between the ages of 15 and 30, it is essential that HIV prevention efforts focus on this demographic. The increased exposure to unsanitary needles and blood may explain why city dwellers appear more vulnerable than rural residents. The findings confirm that HIV is a serious threat to public health in Faisalabad, Pakistan. Community health professionals must work together to educate the public and come up with other solutions to this problem.
Optimalisasi Pengetahuan Ibu Postpartum tentang Teknik Menyusui untuk Mencegah Masalah Laktasi di Puskesmas Watu Alo
Authors: Afrinita Maria , Padeng Eufrasi P. , Trisnawati Reineldis , Halu Silvia Angela Norce 
Published: September 2024

ABSTRAK Penyebab kegagalan dalam menyusui salah satu diantaranya adalah kurang atau tidak sama sekali mempunyai pengalaman serta pengetahuan tentang bagaimana cara menyusui yang benar. Sehingga sangat penting dilakukan penyuluhan tentang Kesehatan selama menyusui dan Teknik menyusui yang benar untuk mempersiapkan fisik dan psikologis ibu untuk memberikan ASI pada bayi. Memberikan asuhan pada ibu nifas dengan melakukan penyuuluhan dan demonstrasi cara menyusui yang benar untuk mengatasi masalah laktasi. Pemecahan masalah yang dilakukan dalam kegiatan pengabdian masyarakat ini adalah memberikan edukasi dengan media leaflet dan demonstrasi tentang Teknik menyusui yang baik. Dari edukasi dan demonstrasi yang dilakukan diperoleh hasil bahwa ibu mengerti dan dapat mempraktikan cara menyusui dengan baik. Adanya peningkatan pengetahuan ibu dimana dapat mempraktikan kembali Teknik menyusui yang benar dan cara meningkatkan produksi ASI sehingga diharapkam kepada ibu-ibu postpartum yang telaah diberikan edukasi dan pelatihan Teknik menyusui ini dapat mewujudkan tercapainya ASI Ekslusif. Kata Kunci: Pengetahuan, Teknik Menyusui, Postpartum ABSTRACT One of the causes of failure in breastfeeding is lack or no experience and knowledge of how to breastfeed correctly. So it is very important to carry out counseling about health during breastfeeding and correct breastfeeding techniques to prepare the mother physically and psychologically to give breast milk to the baby. Provide care to postpartum mothers by conducting counseling and demonstration of the correct way to breastfeed to overcome lactation problems. The problem solving carried out in this community service activity is to provide education with leaflet media and demonstrations about good breastfeeding techniques. From the education and demonstrations carried out, the results were obtained that mothers understood and could practice breastfeeding properly. there is an increase in maternal knowledge where they can practice the correct breastfeeding techniques and how to increase breast milk production so that it is hoped that postpartum mothers who are studied to be given education and training in breastfeeding techniques can realize the achievement of Exclusive Breastfeeding. Keywords: Knowledge, Postpartum Breastfeeding Techniques, Lactation Problems
Pendidikan Kesehatan tentang Spiritual Emosional Freedom Technique (SEFT) dan dampaknya terhadap Penderita Stroke
Authors: Utomo Budi Setia , Zainaro M. Arifki , Isnainy Usastiawaty Cik Ayu Saadiah 
Published: September 2024

ABSTRAK Spiritual emotional freedom technique (SEFT) merupakan salah satu teknik pengobatan alternatif yang telah cukup lama dikenal. Teknik ini merupakan pengembangan dari teknik lain yang diperkenalkan oleh anak bangsa. SEFT termasuk tehnik relaksasi, merupakan salah satu bentuk pengobatan alternatif yang lebih mudah dan aman dibandingkan akupuntur dan akupresur. Karena sifatnya yang mudah dan murah maka penyebarluasan teknik ini lebih mudah untuk dilakukan, salah satunya pada warga Dusun GG. salak II, kemiling permai, kec,kemiling permai, kab. bandar lampung. Warga Dusun GG. salak II, kemiling permai, kec,kemiling permai, kab. bandar lampung yang telah memperoleh informasi tentang metode ini dapat menggunakannya sebagai pengobatan alternatif dan terapi SEFT (spiritual emotional freedom technique) adalah terapi dengan menggunakan gerakan sederhana yang dilakukan untuk membantu menyelesaikan masalah permasalahan sakit fisik maupun psikis, meningkatkan kinerja dan prestasi, meraih kedamaian dan prestasi serta kebermaknaan hidup. Kata Kunci: SEFT,Terapi SEFT, Stroke ABSTRACT Spiritual emotional freedom technique (SEFT) is an alternative medicine technique that has been known for a long time. This technique is a development of other techniques introduced by the nation's children. SEFT, including relaxation techniques, is a for-m of alternative treatment that is easier and safer than acupuncture and acupressure. Because it is easy and cheap, it is easier to disseminate this technique, one of which is to the residents of GG Hamlet. salak II, kemiling permai, kec, kemiling permai, kab. Bandar Lampung. Residents of GG Hamlet. salak II, kemiling permai, kec, kemiling permai, kab. Bandar Lampung who have received information about this method can use it as an alternative treatment and SEFT therapy (spiritual emotional freedom technique) is a therapy using simple movements that is carried out to help solve problems of physical and psychological pain, improve performance and achievement, achieve peace and achievement. and the meaning of life. Keyword: Seft, Seft Therapy,Stroke