bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Anti-Tissue Type Plasminogen Activator Antibodies in Patients With Prosthetic Heart Valve Thrombosis
Authors: Özkan Mehmet , Kalçık Macit , Gürsoy Mustafa Ozan , Öcal Lütfi , Griffini Samantha , Karakoyun Süleyman , Yesin Mahmut , Gündüz Sabahattin , Astarcıoğlu Mehmet Ali , Bayam Emrah , Cerşit Sinan , Aykan Ahmet Çağrı , Cugno Massimo 
Published: December 2015

Background: Thrombolysis is an effective treatment strategy for prosthetic valve thrombosis (PVT). Recombinant tissue-type plasminogen activator (rt-PA) is widely used as a thrombolytic agent. Infusion of rt-PA may trigger the production of anti–tissue plasminogen activator (tPA) antibodies (ATAs). We aimed to evaluate the possible relationship between ATA levels and PVT formation, and the role of baseline ATA levels on outcomes of thrombolytic therapy in patients with PVT. Methods: This prospective, single-center cohort study included 28 patients with PVT undergoing thrombolysis and 31 controls with normal prostheses. Plasma samples were collected from patients with PVT at baseline and at 15th, 30th, 90th, and 180th days after thrombolysis and from controls at baseline only. The ATA levels were assessed in human plasma by an enzyme-linked immunosorbent assay. Results: Baseline ATA-immunoglobulin (Ig) G and IgM were significantly higher in patients with PVT than in controls. The levels of IgM and IgG peaked at 15th and 30th days after rt-PA infusion, respectively. Subtherapeutic international normalized ratio and baseline ATA-IgM were independent predictors of PVT. Thrombolysis failed in 6 patients (21%) in whom baseline IgM levels were significantly higher than successfully lysed patients. Rethrombosis occurred in 9 patients (32%) in whom baseline IgG levels were significantly higher than those without rethrombosis. There was a moderate positive correlation between baseline and 15th-day IgM levels and the dose of rt-PA needed for successful lysis. Conclusion: The ATA levels tended to be higher in patients with PVT at the time of initial diagnosis compared to controls without PVT. In addition, such patients with PVT and high ATA levels may be at high risk for failed thrombolysis or rethrombosis.
Paucity of trauma literature from a highly burdened developing country
Authors: Sultan Rizwan , Zafar Hasnian 
Published: December 2015

Introduction Trauma is the leading cause of death among a younger population not only in USA but in Pakistan as well. The high prevalence of disease should result in a larger amount of data and a larger number of publications resulting in the ability to explore improvements in the field. This study aimed to review the trauma literature generated from Pakistan. Methods Journals indexed with PubMed from January 2010 to December 2014 were searched using the search term “Trauma AND Pakistan” filtering for relevant dates and human reports only. The abstracts and articles were reviewed by the authors to collect data on a proforma. Results 114 articles were published from Pakistan during these five years; 64% of articles were published in international journals; 63% of articles were published in journals with an Impact Factor less than 1; 54% of articles were published from one of four provinces of Pakistan; 64% of articles provided Level 4 evidence whilst another 14% of articles provided Level 5 evidence on the topic; 55% of articles discussed epidemiology in non-representative populations. Conclusions Trauma literature from Pakistan is not only lacking significantly in quantity but is also of poor quality and is unable to offer conclusions on a particular trauma subject. There is huge room for improvement in the upcoming years.
Impairments of the Primary Afferent Nerves in a Rat Model of Diabetic Visceral Hyposensitivity
Authors: Dong Li , Liang Xizi , Sun Biying , Ding Xiaowei , Han Hangxiu , Zhang Guohua , Rong Weifang 
Published: December 2015

Background Diabetic neuropathy in visceral organs such as the gastrointestinal (GI) tract is still poorly understood, despite that GI symptoms are among the most common diabetic complications. The present study was designed to explore the changes in visceral sensitivity and the underlying functional and morphological deficits of the sensory nerves in short-term diabetic rats. Here, we compared the colorectal distension (CRD)-induced visceromotor response (VMR, an index of visceral pain) in vivo, the mechanosensitivity of colonic afferents ex vivo as well as the expression of protein gene product (PGP) 9.5 and calcitonin gene-related peptide (CGRP) in colon between diabetic (3–6 weeks after streptozotocin injection) and control (age-matched vehicle injection) rats. Results VMR was markedly decreased in the diabetic compared to the control rats. There was a significant decrease in multiunit pelvic afferent nerve responses to ramp distension of the ex vivo colon and single unit analysis indicated that an impaired mechanosensitivity of low-threshold and wide dynamic range fibers may underlie the afferent hyposensitivity in the diabetic colon. Fewer PGP 9.5- or CGRP-immunoreactive fibers and lower protein level of PGP 9.5 were found in the colon of diabetic rats. Conclusions These observations revealed the distinctive feature of colonic neuropathy in short-term diabetic rats that is characterized by a diminished sensory innervation and a blunted mechanosensitivity of the remnant sensory nerves.
Platelet-derived growth factor (PDGF)-AA/AB in human serum are potential indicators of the proliferative capacity of human synovial mesenchymal stem cells
Authors: Mizuno Mitsuru , Katano Hisako , Otabe Koji , Komori Keiichiro , Matsumoto Yukie , Fujii Shizuka , Ozeki Nobutake , Tsuji Kunikazu , Koga Hideyuki , Muneta Takeshi , Matsuyama Akifumi , Sekiya Ichiro 
Published: December 2015

Abstract
Introduction
For expansion of human mesenchymal stem cells (MSCs), autologous human serum is safer than fetal bovine serum in clinical situations. One of the problems with the use of autologous human serum is that its proliferative effect on MSCs varies widely between donors. The threefold goals of this study were: (1) to demonstrate an improved method for preparing human serum; (2) to identify growth factors predictive of proliferative potential; and (3) to identify a cytokine to promote MSC proliferation in human serum.

Methods
Fresh blood was collected using a closed bag system containing glass beads. The bag was shaken at 20 °C for 30 minutes for rapid preparation, or kept stationary at 4 °C for 24 hours for slow preparation. Passage 0 synovial MSCs derived from four donors were cultured with 10 % conventional rapid preparation serum or modified slow preparation serum from four different donors. To perform the colony-forming unit assay, synovial MSCs were cultured in these serums. The protein expression profile in serum was analyzed using cytokine array. The candidate proteins were speculated from the correlation between the colony-forming ability and protein expression. As an evaluation of the candidate proteins, proliferation ability, surface marker phenotype and differentiation capability of synovial MSCs were examined.

Results
Compared with rapid preparation serum, slow preparation serum resulted in a significantly higher total colony number and twofold higher expression levels of nine proteins (angiopoietin-1, BDNF, EGF, ENA-78, IGFBP-2, platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, RANTES and TfR). Colony number was positively correlated with PDGF-AA/AB concentrations. Exogenous PDGF-AA significantly promoted proliferation of synovial MSCs, whereas PDGF receptor (PDGFR) inhibitor decreased it. Addition of PDGFs or PDGFR inhibitor did not affect surface epitopes of synovial MSCs. Pretreatment with PDGFs or PDGFR inhibitor did not affect chondrogenic, adipogenic, or calcification potentials of synovial MSCs.

Conclusion
Slow preparation serum contained higher concentrations of PDGF-AA/AB and increased the colony formation number of synovial MSCs. PDGF-AA/AB were indicators of the proliferative potential of human serum. Exogenous PDGF-AA increased proliferation of synovial MSCs without alteration of surface epitopes and differentiation potentials.
On the construction of metrics from fuzzy metrics and its application to the fixed point theory of multivalued mappings
Authors: Castro-Company Francisco , Romaguera Salvador , Tirado Pedro 
Published: December 2015

AbstractWe present a procedure to construct a compatible metric from a given fuzzy metric space. We use this approach to obtain a characterization of a large class of complete fuzzy metric spaces by means of a fuzzy version of Caristi’s fixed point theorem, obtaining, in this way, partial solutions to a recent question posed in the literature. Some illustrative examples are also given.
Metal Nanostructures Fabricated by the Difference of Interfacial Energy at a Dielectric/Metal Interface
Authors: Tatsuno Toshinao , Okamoto Takayuki , Ezaki Tomotarou , Isobe Toshihiro , Nakajima Akira , Matsushita Sachiko 
Published: December 2015

Abstract
Due to its high sensitivity to changes in the environmental dielectric constant, localized surface plasmon resonance (LSPR) is utilized for various sensing materials. However, because of this high sensitivity, it is difficult to detect a specific substance among mixed materials. Here, we enhanced the size selectivity using a metal nanostructure. By preparing a cup-like metal nanostructure that is the same size as a virus, this cup-like structure may be able to capture a virus, and thus the LSPR characteristics would change. This phenomenon would not occur for larger materials, such as animal cells, i.e., this cup-like structure may have selectivity for material size. In this paper, we fabricated metal nanocups out of two-dimensional colloidal crystals by exploiting the difference of interfacial energy at a dielectric/metal interface. The size selectivity and plasmon characteristics of the fabricated metal nanocups were investigated with model viruses, i.e., virus-like polystyrene (PSt) nanoparticles with almost the same dielectric constant and size as a virus. As a result, the transmission spectra show a 20-nm red shift in the visible light range before and after adsorption of the model virus. Field emission scanning electron microscopy (FE-SEM), optical microscopy, UV–vis spectrometry and contact angle measurement results are also discussed.
Cannabis microbiome sequencing reveals several mycotoxic fungi native to dispensary grade Cannabis flowers
Authors: McKernan Kevin , Spangler Jessica , Zhang Lei , Tadigotla Vasisht , Helbert Yvonne , Foss Theodore , Smith Douglas R. 
Published: December 2015

The Center for Disease Control estimates 128,000 people in the U.S. are hospitalized annually due to food borne illnesses. This has created a demand for food safety testing targeting the detection of pathogenic mold and bacteria on agricultural products. This risk extends to medicalCannabisand is of particular concern with inhaled, vaporized and even concentratedCannabisproducts.As a result, third party microbial testing has become a regulatory requirement in the medical and recreationalCannabismarkets, yet knowledge of theCannabismicrobiome is limited. Here we describe the first next generation sequencing survey of the microbial communities found in dispensary basedCannabisflowers and demonstrate the limitations in the culture-based regulations that are being superimposed from the food industry.
Opening Up Intellectual Property Strategy: Implications for Open Source Software Entry by Start-up Firms
Authors: Wen Wen , Ceccagnoli Marco , Forman Chris 
Published: December 2015

We examine whether a firm’s intellectual property (IP) strategy in support of the open source software (OSS) community stimulates new OSS product entry by start-up software firms. In particular, we analyze the impact of strategic decisions taken by IBM around the mid-2000s, such as its announcement that it will not assert its patents against the OSS community and its creation of a patent commons. These decisions formed a coherent IP strategy in support of OSS. We find that IBM’s actions stimulated new OSS product introductions by entrepreneurial firms and that their impact is increasing in the cumulativeness of innovation in the market and the extent to which patent ownership in the market is concentrated.Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2247 .This paper was accepted by Lee Fleming, entrepreneurship and innovation.
Asymmetric Effects of Informed Trading on the Cost of Equity Capital
Authors: Brennan Michael J. , Huh Sahn-Wook , Subrahmanyam Avanidhar 
Published: December 2015

We decompose PIN, the probability of informed trading, into good-news (PIN_G) and bad-news (PIN_B) components, which we estimate at a quarterly frequency. We first assess the validity of PIN as a measure of informed trading by calculating its association with measures of the adverse-selection component of the cost of trading. We then provide new evidence that PIN_G and PIN_B capture informed trading around earnings announcements by showing that they predict positive and negative earnings surprises, respectively. Conjecturing that investors who take long positions will be more concerned about informed selling than about informed buying since the former depresses the sale price whereas the latter raises it, we then investigate asymmetry in the pricing of private information. We find strong evidence of such asymmetry in that the effect of PIN_B on the cost of equity capital is large and highly significant, whereas the effect of PIN_G is small and statistically insignificant. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2250 . This paper was accepted by Neng Wang, finance.
Inferring Quality from Wait Time
Authors: Kremer Mirko , Debo Laurens 
Published: December 2015

We study the impact of wait time on consumers’ purchasing behavior when product quality is unknown to some consumers (the “uninformed consumers”) but known to others (the “informed consumers”). In a capacitated environment, wait times act as a signal of quality for uninformed consumers because, due to informed consumers in the population, low (high) quality products tend to generate shorter (longer) wait times. Hence, longer wait times may increase uninformed consumers’ perceived quality, and they may still purchase the product, even when the wait time is long. Similarly, short wait times decrease the consumers’ perceived quality, and they may walk away despite the short wait—the “empty restaurant syndrome.” This paper develops and tests a theory of observational learning that predicts these effects. We find that uninformed consumers’ purchasing probability at short waits decreases in the presence of informed consumers. Furthermore, we find that relatively few informed consumers suffice to create this effect. Finally, we show that the purchasing frequency might even increase in the wait time. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2264 . This paper was accepted by Martin Lariviere, operations management.
Treatment of the diabetic foot by offloading: a systematic review
Authors: de Oliveira A. L. Martins , Moore Z. 
Published: December 2015

Objective: To compare the literature on the strengths and limitations of different offloading devices in the treatment of diabetic foot ulcers. Method: Systematic review of the literature in the following databases: the Cumulative Index to Nursing an Allied Health Literature (CINAHL); Medline; Embase; Cochrane Library and Web of Knowledge. The search strategy used the terms: diabetic foot; orthosis/orthotic devices/orthoses; foot orthosis/foot orthoses; casts/plaster cast/surgical cast; shoes. Results: Our results identified 15 studies, which are included in this review. Healing rates, healing times and reduction in ulcer size were improved with the use of total contact casting, when compared with other offloading devices. The main adverse effects associated with the use of the device were infection, maceration and abrasion. Cost, compliance and quality of life issues were rarely included within the studies. Conclusion: Offloading is a key treatment strategy for the management of diabetic foot ulcers and total contact casts were found to be the most effective devices to achieve ulcer healing. However, they are not without complications and their impact on cost, compliance and quality of life is not well understood.
Temporal variability in macroinvertebrates diversity patterns and their relation with environmental factors
Authors: GERAMI MOHAMMAD HASAN , PATIMAR RAHMAN , NEGARESTAN HOSSEIN , JAFARIAN HOJJATOLLAH , MORTAZAVI MOHAMMAD SEDDIQ 
Published: December 2015

Gerami MH, Patimar R, Negarestan H, Jafarian H, Mortazavi MS. 2015. Temporal variability in macroinvertebratesÂ diversity patterns and their relation with environmental factors. Biodiversitas 17: 36-43. Seasonal changes are the most important factorÂ in temporal variability of macroinvertebrates communities in marine benthic zone. Realizing the pattern of these changes are the keyÂ attributes to maintain benthic resources. For this purpose this study aimed to investigate temporal variability of macroinvertebratesÂ diversity patterns in different seasons in Hormozgan province waters, Persian Gulf. Five sites were identified and sampling was carriedÂ out randomly at three places with three replicate in each site from autumn 2014 to spring 2015. Physiochemical properties of water wereÂ recorded in each sampling site. Total of 19 macroinvertebrate orders were identified form four seasons in all sites. Results showed thatÂ Polychaeta were dominant taxa in all seasons and maximum diversity of benthic macroinvertebrates exhibitedin winter. According toÂ evenness index (E1), abundances of species were most balanced in spring. Analysis of weight and density revealed that the species diversity and mean weight of macroinvertebrates had maximum in winter and minimum in summer. Macroinvertebrate community structure was similar in the spring and summer and partly discriminated from remaining two seasons. SIMPER analysis confirmed these dissimilarities and revealed that Foraminifera, Gastropoda and Polychaeta have three major contributions in dissimilarities between seasons. According to BIO-ENV analysis, oxygen and chlorophyll a were the best variables (r = 0.7143) explaining changes in the abundance over time of the benthic fauna under study. On the contrary, eight orders (Amphipoda, Secernentea, Cumacea, Euphausiacea, Gastropoda, Isopoda, Anthozoa and Sagittoidea)Â did not show any convergence with environmental factors in this study.
FDA Advise-ERR: Mefloquine—Not the Same as Malarone; Zoster Vaccine is Not for the Immunosuppressed; TXA Mistaken as Tenecteplase; Guidelines for Adult IV Push Medications
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: December 2015

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters’ wishes as to the level of detail included in publications.
Co-creation as a process of undoing authenticity
Authors: Barthel Katharina , von Maltzahn Constantin-Felix 
Published: December 2015

Abstract
This article explores the recent emergence of ‘authenticity’ in fashion in the context of tribal brand cultures in which the value of fashion items results from co-creation processes in environments created by online social media. The study used a qualitative approach in the form of a netnographic study, supported by secondary research such as online documents, photographic footage and media reports. Focusing on a young New York City-based outdoor fashion firm, the research explores the life- and experience-worlds of consumers in an online context. Following the tenets of Symbolic Interactionism, the study identified a socially and emotionally charged process of value exchange as a key driver in the relationship between brands and consumers. Social exchange between consumers is where meaning is extracted and symbolic properties are converted into markers of collective identification. While most analyses of co-creation and tribal consumption focus on offor online contexts separately, the present study seeks to develop an understanding of the intersecting dynamics between on- and offline environments.
The Transfer of Drugs and Other Chemicals Into Human Milk
Authors:   Committee on Drugs
Published: December 2015

This Policy Statement was retired May 2010.The American Academy of Pediatrics places emphasis on increasing breastfeeding in the United States. A common reason for the cessation of breastfeeding is the use of medication by the nursing mother and advice by her physician to stop nursing. Such advice may not be warranted. This statement is intended to supply the pediatrician, obstetrician, and family physician with data, if known, concerning the excretion of drugs into human milk. Most drugs likely to be prescribed to the nursing mother should have no effect on milk supply or on infant well-being. This information is important not only to protect nursing infants from untoward effects of maternal medication but also to allow effective pharmacologic treatment of breastfeeding mothers. Nicotine, psychotropic drugs, and silicone implants are 3 important topics reviewed in this statement.
Aquatic and marsh plants from the Recôncavo basin of Bahia state, Brazil: checklist and life forms
Authors: Aona Lidyanne Yuriko Saleme , Costa Grênivel Mota da , Amaral Maria do Carmo E. do , Faria Aparecida Donisete de , Duarte Edson Ferreira , Bittrich Volker 
Published: December 2015

Aquatic and marsh plants are those that have the capacity to withstand a continuous or periodic submersion in water, at least of their roots. Such plants are thus able to occupy environments that are at least periodically waterlogged. The knowledge about this plant group is still rather incomplete for various parts of Brazil including the Northeast. The present study was conducted in Bahia state, through collections in 20 municipalities within the Recôncavo basin between 2009 and 2015. All species were classified across six life forms. We report 316 species in 206 genera and 71 families, including 11 fern species, with helophytes and emergent being the commonest ones. Collection efforts in aquatic environments in the Recôncavo region added nine families of angiosperms to those already reported in previous studies of such plants in Northeastern Brazil. The region presents a wide variety of aquatic and marsh plants and the respective habitats play an important role in the conservation/maintenance of biodiversity and especially of water bodies in Eastern Bahia.