bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is computer navigation when used in the surgery of iliosacral pelvic bone tumours safer for the patient?
Authors: Laitinen M. K. , Parry M. C. , Albergo J. I. , Grimer R. J. , Jeys L. M. 
Published: February 2017

Aims Due to the complex anatomy of the pelvis, limb-sparing resections of pelvic tumours achieving adequate surgical margins, can often be difficult. The advent of computer navigation has improved the precision of resection of these lesions, though there is little evidence comparing resection with or without the assistance of navigation. Our aim was to evaluate the efficacy of navigation-assisted surgery for the resection of pelvic bone tumours involving the posterior ilium and sacrum. Patients and Methods Using our prospectively updated institutional database, we conducted a retrospective case control study of 21 patients who underwent resection of the posterior ilium and sacrum, for the treatment of a primary sarcoma of bone, between 1987 and 2015. The resection was performed with the assistance of navigation in nine patients and without navigation in 12. We assessed the accuracy of navigation-assisted surgery, as defined by the surgical margin and how this affects the rate of local recurrence, the disease-free survival and the effects on peri-and post-operative morbidity. Results The mean age of the patients was 36.4 years (15 to 66). The mean size of the tumour was 10.9 cm. In the navigation-assisted group, the margin was wide in two patients (16.7%), marginal in six (66.7%) and wide-contaminated in one (11.1%) with no intralesional margin. In the non-navigated-assisted group; the margin was wide in two patients (16.7%), marginal in five (41.7%), intralesional in three (25.0%) and wide-contaminated in two (16.7%). Local recurrence occurred in two patients in the navigation-assisted group (22.2%) and six in the non-navigation-assisted group (50.0%). The disease-free survival was significantly better when operated with navigation-assistance (p = 0.048). The blood loss and operating time were less in the navigated-assisted group, as was the risk of a foot drop post-operatively. Conclusion The introduction of navigation-assisted surgery for the resection of tumours of the posterior ilium and sacrum has increased the safety for the patients and allows for a better oncological outcome. Cite this article: Bone Joint J 2017;99-B:261–6.
Trophic state and recreational value of Lake Mikołajskie
Authors: Sieńska Justyna , Dunalska Julita , Łopata Michał , Parszuto Katarzyna , Tandyrak Renata 
Published: February 2017

Abstract
Lakes along with their surroundings are an attractive landscape component that play an important role in recreation and relaxation. In Poland, the Great Masurian Lakeland, visited by a million tourists every year, is considered to be the most attractive lake area. However, tourist pressure has several negative effects which cause degradation of the water environment. The aim of this study was to determine the trophic state of Lake Mikołajskie which is a hub for sailing and motorboating traffic. Values of the trophic status index were calculated from the content of total phosphorus, chlorophyll a and Secchi disc visibility, according to the data from the Voivodeship Inspectorate for Environmental Protection. In summer, the concentration of total phosphorus was 0.019–0.042 mg dm−3 in 2013 and 0.022–0.055 mg dm−3 in 2014. The concentration of chlorophyll a was in the range of 8.3–45.0 μg dm−3 in 2013 and 8.9–22.0 μg dm−3 in 2014. The maximum visibility of Secchi disc reached 2.0 m (2013) and 1.8 m (2014). Based on the calculated, Lake Mikołajskie can be classified as a eutrophic lake. In order to protect lakes from degradation tourists should be educated about the rational use of surface waters and the surrounding catchment. However, it is not only the massive influx of tourists, but also the activity of residents (dictated by economic reasons) that contribute to the pollution of lakes. Therefore, the development of tourism and the economy of the whole region should be harmonious and balanced so that the natural resources can serve us and future generations for as long as possible.
Imagine Paradise in Ads
Authors: Waade Anne Marit 
Published: February 2017

Abstract
Paradise has been a significant concept in tourism as well in consumer culture. The present article demonstrates how paradise is presented as visual, spatial and ideal concepts in ads, and how they illustrate imagination as a central communicative effect in marketing and consumer culture. Through an analysis of selected consumer and tourism ads for TV and cinema presented in Denmark, the author points out different ways of reflecting viewers’ imagination of paradise as a place and condition. The author outlines a theoretical framework for understanding imagination from a media-specific perspective as involving cognitive, emotional and sensuous processes, respectively, and looks at how paradise, as an active and present visual matrix in tourism and consumer communication, has a specific appeal to viewers’ imagination.
Case-Based Reasoning untuk Diagnosis Penyakit Jantung
Authors: Wahyudi Eka , Hartati Sri 
Published: February 2017

Case Based Reasoning (CBR) is a computer system that used for reasoning old knowledge to solve new problems. It works by looking at the closest old case to the new case. This research attempts to establish a system of CBR for diagnosing heart disease. The diagnosis process is done by inserting new cases containing symptoms into the system, then the similarity value calculation between cases uses the nearest neighbor method similarity, minkowski distance similarity and euclidean distance similarity. Case taken is the case with the highest similarity value. If a case does not succeed in the diagnosis or threshold <0.80, the case will be revised by experts. Revised successful cases are stored to add the systemknowledge. Method with the best diagnostic result accuracy will be used in building the CBR system for heart disease diagnosis. The test results using medical records data validated by expert indicate that the system is able to recognize diseases heart using nearest neighbor similarity method, minskowski distance similarity and euclidean distance similarity correctly respectively of 100%. Using nearest neighbor get accuracy of 86.21%, minkowski 100%, and euclidean 94.83%
Pulmonary adenocarcinoma with epidermal growth factor receptor‐mutations in asbestos exposed non‐smokers: A case series
Authors: Kradin Richard L. , Iafrate John , Christiani David C. 
Published: February 2017

BackgroundCigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non‐smokers with adenocarcinoma.Methods Mutations in the EGFR gene were investigated using next‐generation sequencing.ResultsWe report the presence of EGFR exon point mutations in the pulmonary adenocarcinomas of three never‐smokers occupationally exposed to asbestos.ConclusionThe role of asbestos as a possible cause of EGFR mutagenesis requires further investigation. Am. J. Ind. Med. 60:306–309, 2017. © 2017 Wiley Periodicals, Inc.
Adamantylidene Addition to M3N@Ih‐C80 (M=Sc, Lu) and Sc3N@D5h‐C80: Synthesis and Crystallographic Characterization of the [5,6]‐Open and [6,6]‐Open Adducts
Authors: Yamada Michio , Abe Tsuneyuki , Saito Chiharu , Yamazaki Toshiki , Sato Satoru , Mizorogi Naomi , Slanina Zdenek , Uhlík Filip , Suzuki Mitsuaki , Maeda Yutaka , Lian Yongfu , Lu Xing , Olmstead Marilyn M. , Balch Alan L. , Nagase Shigeru , Akasaka Takeshi 
Published: February 2017

AbstractAdditions of adamantylidene (Ad) to M3N@Ih‐C80 (M=Sc, Lu) and Sc3N@D5h‐C80 have been accomplished by photochemical reactions with 2‐adamantyl‐2,3′‐[3H]‐diazirine (1). In M3N@Ih‐C80, the addition led to rupture of the [6,6]‐ or [5,6]‐bonds of the Ih‐C80 cage, forming the [6,6]‐open fulleroid as the major isomer and the [5,6]‐open fulleroid as the minor isomer. In Sc3N@D5h‐C80, the addition also proceeded regioselectively to yield three major isomeric Ad mono‐adducts, despite the fact that there are nine types of C−C bonds in the D5h‐C80 cage. The molecular structures of the seven Ad mono‐adducts, including the positions of the encaged trimetallic nitride clusters, have been unambiguously determined through single‐crystal XRD analyses. Furthermore, results have shown that stepwise addition of Ad to Lu3N@Ih‐C80 affords several Ad bis‐adducts, two of which have been isolated and characterized. The X‐ray structure of one bis‐adduct clearly revealed that the second Ad addition took place at a [6,6]‐bond close to an endohedral metal atom. Theoretical calculations have also been performed to rationalize the regioselectivity.
One pot peroxidation of oleic acid rich Azadirachta indica oil over bio‐waste derived heterogeneous catalyst
Authors: Sahu Himadri , Mohanty Kaustubha 
Published: February 2017

AbstractIn this work, a heterogeneous catalyst was developed from waste fish bone. ZnO was deposited onto the waste fish bone to enhance the surface properties along with ion exchangeability. After characterization, the developed catalyst was found to have a much higher surface area (217 m2 · g−1) than that of raw fish bone (10 m2 · g−1). This catalyst was used during peroxidation of oleic acid rich Azadirachta indica oil (neem oil) to observe its suitability and efficiency. A quadratic model was developed with five input variables (temperature (T), time (t), g/g of catalyst (HZn), H2O2:oil ratio (γH:FA), formic acid:oil ratio (γF:FA)) and 2 output variables (Iodine value, Oxirane Oxygen Conversion). The optimized parametric values for T, t, HZn, γH:FA, and γF:FA were found to be 60 °C, 3.88 h, 20 g/g, 19.05:1, and 19.85:1 respectively. The final epoxidized oil was characterized using FTIR and 1HNMR. The reusability of the catalyst was studied both quantitatively and qualitatively.
Witterungsbedingte Lackschäden früher erkennen
Authors: Oehler Harald , Wanner Matthias , Alig Ingo 
Published: February 2017

AbstractSchwankende Temperaturen, Sonnenstrahlung, Feuchte, chemische Substanzen und mechanische Belastungen schädigen Lackierungen und Beschichtungen. Um sie beständig zu machen, ist es erforderlich, die Alterungsmechanismen besser zu verstehen und Schädigungen möglichst frühzeitig zu detektieren.
Wasserstoffkatalyse in Mikroalgen
Authors: Senger Moritz , Stripp Sven 
Published: February 2017

AbstractHydrogenasen in Grünalgen katalysieren die Abgabe von Wasserstoff. Wie läuft das auf molekularer Ebene ab? Isotopenmarkierung und Infrarotspektroskopie helfen, diese Frage zu beantworten.
Gesellschaft chinesischer Chemiker tagt in München
Authors: Shao Huawei , Wang Rongbiao 
Published: February 2017

AbstractDie 28. Jahrestagung der Gesellschaft Chinesischer Chemiker und Chemieingenieure in der Bundesrepublik Deutschland (GCCCD) stand unter dem Motto “Chemie und Chemie‐Engineering für nachhaltige Entwicklung“. Die zweitägige Veranstaltung fand Ende Oktober zum ersten Mal in München statt. 150 Gäste und GCCCD‐Mitglieder aus Hochschulen und chemischer Industrie nahmen an der Tagung teil.
Die dunkle Seite der Exzellenz
Authors: Al‐Shamery Katharina 
Published: February 2017

AbstractIm Jahr 1867 gründete sich die Deutsche Chemische Gesellschaft, die ältere der beiden Vorgängerorganisationen der GDCh. Exzellente Wissenschaft steht von Anfang auf der Fahne der Gesellschaft. Doch verführt der Zwang zur Exzellenz in Zeiten eines gewaltigen Publikationsdrucks nicht allzu leicht zu unethischem Verhalten?
1,25(OH)2D3 attenuates hepatic steatosis by inducing autophagy in mice
Authors: Li Renlong , Guo Enshuang , Yang Jiankun , Li Anyi , Yang Yan , Liu Shenpei , Liu Anding , Jiang Xiaojing 
Published: February 2017

Objective1,25(OH)2D3 has been reported to attenuate liver steatosis; however, its exact mechanism of action remains poorly understood. This study aimed to determine whether 1,25(OH)2D3 can attenuate hepatic steatosis by inducing autophagy.MethodsMale C57BL/6 mice fed a high‐fat diet (HFD) were injected with 1,25(OH)2D3 for 4 weeks. These mice were given 3‐methyladenine (3‐MA) to inhibit autophagy. HepG2 cells were preincubated with a free fatty acid (FFA) and then treated with 1,25(OH)2D3. Vitamin D receptor (VDR) shRNA and autophagy‐related 16‐like 1 (ATG16L1) siRNA were used for VDR knockdown or ATG16L1 silencing, respectively.Results1,25(OH)2D3 diminished HFD‐induced liver damage and steatosis, changes accompanied by autophagy and ATG16L1 expression upregulation. Inhibition of 1,25(OH)2D3‐induced autophagy mediated by 3‐MA blocked the protective effects of 1,25(OH)2D3 on hepatic steatosis. Additionally, 1,25(OH)2D3‐induced autophagy appeared to play a role in anti‐inflammation and lipid metabolism modulation in the liver. In HepG2 cells, 1,25(OH)2D3 reduced lipid accumulation and increased autophagy and ATG16L1 expression; however, this effect was abrogated after VDR knockdown. The protective effects of 1,25(OH)2D3‐mediated autophagy against lipid accumulation were abolished by 3‐MA. Furthermore, siRNA‐mediated ATG16L1 knockdown prevented 1,25(OH)2D3‐induced autophagy, resulting in increased fat accumulation.ConclusionsThe data suggest that 1,25(OH)2D3 may ameliorate hepatic steatosis by inducing autophagy by upregulating ATG16L1.
Incremental comprehension of Japanese passives: Evidence from the visual-world paradigm
Authors: MITSUGI SANAKO 
Published: February 2017

ABSTRACTPsycholinguistic research has shown that sentence processing is incremental (e.g., Altmann & Kamide, 1999). In Japanese, a verb-final language, native speakers use case markers to incrementally assign thematic roles and predictively activate a structural representation of upcoming linguistic items. This study examined whether second-language learners of Japanese, guided by case markers, generate predictions as to whether the upcoming verb involves the active or passive voice. The results show that the native speakers made predictive eye movements before the verb, but the learners did not; the learners were less efficient in using case-marker cues than the native speakers and relied more on verb morphology information. These results suggest that case markers guide thematic role assignments, expediting the processing for Japanese native speakers. Learners may depend more on information from the verb to compensate for the inefficiency in case-marker-driven predictive processing.
Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes
Authors: Hunter Jennifer C. , Mu Yi , Dumyati Ghinwa K. , Farley Monica M. , Winston Lisa G. , Johnston Helen L. , Meek James I. , Perlmutter Rebecca , Holzbauer Stacy M. , Beldavs Zintars G. , Phipps Erin C. , Dunn John R. , Cohen Jessica A. , Avillan Johannetsy , Stone Nimalie D. , Gerding Dale N. , McDonald L. Clifford , Lessa Fernanda C. 
Published: February 2017

Abstract
Background.  Approximately 4 million Americans receive nursing home (NH) care annually. Nursing home residents commonly have risk factors for Clostridium difficile infection (CDI), including advanced age and antibiotic exposures. We estimated national incidence of NH-onset (NHO) CDI and patient outcomes.
Methods.  We identified NHO-CDI cases from population-based surveillance of 10 geographic areas in the United States. Cases were defined by C difficile-positive stool collected in an NH (or from NH residents in outpatient settings or ≤3 days after hospital admission) without a positive stool in the prior 8 weeks. Medical records were reviewed on a sample of cases. Incidence was estimated using regression models accounting for age and laboratory testing method; sampling weights were applied to estimate hospitalizations, recurrences, and deaths.
Results.  A total of 3503 NHO-CDI cases were identified. Among 262 sampled cases, median age was 82 years, 76% received antibiotics in the 12 weeks prior to the C difficile-positive specimen, and 57% were discharged from a hospital in the month before specimen collection. After adjusting for age and testing method, the 2012 national estimate for NHO-CDI incidence was 112 800 cases (95% confidence interval [CI], 93 400–131 800); 31 400 (28%) were hospitalized within 7 days after a positive specimen (95% CI, 25 500–37 300), 20 900 (19%) recurred within 14–60 days (95% CI, 14 600–27 100), and 8700 (8%) died within 30 days (95% CI, 6600–10 700).
Conclusions.  Nursing home onset CDI is associated with substantial morbidity and mortality. Strategies focused on infection prevention in NHs and appropriate antibiotic use in both NHs and acute care settings may decrease the burden of NHO CDI.
Temperature-driven selection on metabolic traits increases the strength of an algal-grazer interaction in naturally warmed streams
Authors: Schaum C. -Elisa ,   Bio244 Students, ffrench-Constant Richard , Lowe Chris , Ólafsson Jón S , Padfield Daniel , Yvon-Durocher Gabriel 
Published: February 2017

ABSTRACTTrophic interactions are important determinants of the structure and functioning of ecosystems. As the metabolism and consumption rates of ectotherms increase sharply with temperature, there are major concerns that global warming will increase the strength of trophic interactions, destabilizing food webs, and altering ecosystem structure and function. We used geothermally warmed streams that span a ∼10°C temperature gradient to investigate the interplay between temperature-driven selection on traits related to metabolism and resource acquisition, and the interaction strength between the keystone gastropod grazer, the wandering snailRadix balthica, and a common algal resource. Populations from a warm stream (∼28°C) had higher maximal metabolic rates and optimal temperatures than their counterparts from a cold stream (∼17°C). We found that metabolic rates of the population originating from a warmer stream were higher across all measurement temperatures. A reciprocal transplant experiment demonstrated that the interaction strengths between the grazer and its algal resource were highest for both populations when transplanted into the warm stream. In line with the thermal dependence of respiration, interaction strengths of grazers from the warm stream were always higher than those of grazers from the cold stream. These findings suggest that warming can increase the strength of algal-grazer interactions through the thermodynamic effects of higher temperatures on physiological rates as well as through correlated increases inper capitametabolism and consumption.
Financial performance and non‐family CEO turnover in private family firms under different conditions of ownership and governance
Authors: Visintin Francesca , Pittino Daniel , Minichilli Alessandro 
Published: February 2017

AbstractManuscript TypeEmpiricalResearch Question/IssueFamily firms, as insider‐controlled companies, should be less likely to exhibit CEO turnover after poor performance and may thus promote enhanced focus on long‐term goals. However, when a non‐family CEO is in charge, the relatively limited empirical evidence is contrasting. Some studies find that only family CEOs are immune from the threat of dismissal following poor financial performance, while other studies show that family firms discipline their CEOs for poor financial performance regardless of their family status. In this work, we try to reconcile these contrasting findings and investigate what ownership and governance conditions influence the owners’ pressure on the CEO to achieve short‐term financial results.Research findings/insightsDrawing on a longitudinal dataset that covers the entire population of Italian medium and large family companies, we find that when family ownership is concentrated in the hands of few family shareholders or there is a low number of family members involved in the board of directors, non‐family CEOs are less likely to be dismissed after poor performance.Theoretical/Academic ImplicationsOur study, adopting the behavioral agency theory as the guiding framework, highlights the importance for governance decisions of the potential goal divergence among principals in closely held ownership structures. Our results also add to the still scant literature on the relationship between family owners and non‐family CEOs.Practitioner/Policy ImplicationsOur research suggests that, in the decision to hire a non‐family CEO, family business owners should not only assess their gaps in managerial skills but also carefully consider the ownership structure and family involvement conditions. On the side of professional non‐family managers, our results offer insights on ways to address the employment relationship with the controlling family.
Effect of team sports and resistance training on physical function, quality of life, and motivation in older adults
Authors: Pedersen M. T. , Vorup J. , Nistrup A. , Wikman J. M. , Alstrøm J. M. , Melcher P. S. , Pfister G. U. , Bangsbo J. 
Published: February 2017

The aim of this study was to investigate the effect of team sports and resistance training on physical function, psychological health, quality of life, and motivation in older untrained adults. Twenty‐five untrained men and forty‐seven untrained women aged 80 (range: 67‐93) years were recruited. Fifty‐one were assigned to a training group (TRG) of which twenty‐five performed team training (TG) and twenty‐six resistance training (RG). The remaining twenty‐one were allocated to a control group (CG). TRG trained for 1 hour twice a week for 12 weeks. Compared with CG, TRG improved the number of arm curls within 30 seconds (P<.05) and 30‐seconds chair stand (P<.05) during the intervention. In TRG, participation in training led to higher (P<.05) scores in the subscales psychological well‐being, general quality of life, and health‐related quality of life, as well as decreased anxiety and depression levels. No differences between changes in TG and RG were found over the intervention period, neither in physical function tests nor psychological questionnaires. Both TG and RG were highly motivated for training, but TG expressed a higher degree of enjoyment and intrinsic motivation mainly due to social interaction during the activity, whereas RG was more motivated by extrinsic factors like health and fitness benefits. In conclusion, both team training and resistance training improved physical function, psychological well‐being, and quality of life. However, team sport training motivated the participants more by intrinsic factors than resistance training.