bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tribological Properties of Water-lubricated Rubber Materials after Modification by MoS2 Nanoparticles
Authors: Dong Conglin , Yuan Chengqing , Wang Lei , Liu Wei , Bai Xiuqin , Yan Xinping 
Published: October 2016

AbstractFrictional vibration and noise caused by water-lubricated rubber stern tube bearings, which are generated under extreme conditions, severely threaten underwater vehicles’ survivability and concealment performance. This study investigates the effect of flaky and spherical MoS2nanoparticles on tribological properties and damping capacity of water-lubricated rubber materials, with the aim of decreasing frictional noise. A CBZ-1 tribo-tester was used to conduct the sliding tests between rubber ring-discs and ZCuSn10Zn2ring-discs with water lubrication. These materials’ typical mechanical properties were analysed and compared. Coefficients of friction (COFs), wear rates, and surface morphologies were evaluated. Frictional noise and critical velocities of generating friction vibration were examined to corroborate above analysis. Results showed that spherical MoS2nanoparticles enhanced rubber material’s mechanical and tribological properties and, in turn, reduced the friction noise and critical velocity. Flaky MoS2nanoparticles reduced COF but did not enhance their mechanical properties, i.e., the damping capacity, wear resistance property; thus, these nanoparticles did not reduce the critical velocity obviously, even though increased the frictional noise at high load. The knowledge gained in the present work will be useful for optimizing friction pairs under extreme conditions to decrease frictional noise of water-lubricated rubber stern tube bearings.
PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A
Authors: Uddbäck Ida E. M. , Steffensen Maria A. , Pedersen Sara R. , Nazerai Loulieta , Thomsen Allan R. , Christensen Jan P. 
Published: October 2016

AbstractRecently, we showed that combined intranasal and subcutaneous immunization with a non-replicating adenoviral vector expressing NP of influenza A, strain PR8, induced long-standing protection against a range of influenza A viruses. However, H-2b mice challenged with an influenza A strain mutated in the dominant NP366 epitope were not efficiently protected. To address this problem, we envision the use of a cocktail of adenovectors targeting different internal proteins of influenza A virus. Consequently, we investigated the possibility of using PB1 as a target for an adenovector-based vaccine against influenza A. Our results showed that PB1 is not as immunogenic as the NP protein. However, by tethering PB1 to the murine invariant chain we were able to circumvent this problem and raise quite high numbers of PB1-specific CD8+ T cells in the circulation. Nevertheless, mice immunized against PB1 were not as efficiently protected against influenza A challenge as similarly NP-vaccinated animals. The reason for this is not a difference in the quality of the primed cells, nor in functional avidity. However, under similar conditions of immunization fewer PB1-specific cells were recruited to the airways, and surface expression of the dominant PB1 peptide, PB1703, was less stable than in the case of NP366.
Thermal and Thermoelectric Transport in Highly Resistive Single Sb2Se3 Nanowires and Nanowire Bundles
Authors: Ko Ting-Yu , Shellaiah Muthaiah , Sun Kien Wen 
Published: October 2016

AbstractIn this study, we measured the thermal conductivity and Seebeck coefficient of single Sb2Se3 nanowires and nanowire bundles with a high resistivity (σ ~ 4.37 × 10−4 S/m). Microdevices consisting of two adjacent suspended silicon nitride membranes were fabricated to measure the thermal transport properties of the nanowires in vacuum. Single Sb2Se3 nanowires with different diameters and nanowire bundles were carefully placed on the device to bridge the two membranes. The relationship of temperature difference on each heating/sensing suspension membranes with joule heating was accurately determined. A single Sb2Se3 nanowire with a diameter of ~ 680 nm was found to have a thermal conductivity (kNW) of 0.037 ± 0.002 W/m·K. The thermal conductivity of the nanowires is more than an order of magnitude lower than that of bulk materials (k ~ 0.36–1.9 W/m·K) and highly conductive (σ ~ 3 × 104 S/m) Sb2Se3 single nanowires (k ~ 1 W/m·K). The measured Seebeck coefficient with a positive value of ~ 661 μV/K is comparable to that of highly conductive Sb2Se3 single nanowires (~ 750 μV/K). The thermal transport between wires with different diameters and nanowire bundles was compared and discussed.
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
Authors: Fu Xiaoyong , Jeselsohn Rinath , Pereira Resel , Hollingsworth Emporia F. , Creighton Chad J. , Li Fugen , Shea Martin , Nardone Agostina , De Angelis Carmine , Heiser Laura M. , Anur Pavana , Wang Nicholas , Grasso Catherine S. , Spellman Paul T. , Griffith Obi L. , Tsimelzon Anna , Gutierrez Carolina , Huang Shixia , Edwards Dean P. , Trivedi Meghana V. , Rimawi Mothaffar F. , Lopez-Terrada Dolores , Hilsenbeck Susan G. , Gray Joe W. , Brown Myles , Osborne C. Kent , Schiff Rachel 
Published: October 2016

SignificanceOne of the mechanisms of endocrine resistance in estrogen receptor α (ER)-positive (+) breast cancer is the cross-talk between the ER and growth factor receptor pathways leading to altered ER activity and a reprogrammed ER-dependent transcriptome. However, key mediators of this ER-dependent transcriptional reprogramming remain elusive. Here we demonstrate that forkhead box protein A1 (FOXA1) up-regulation via gene amplification or overexpression contributes to endocrine resistance and increased invasiveness phenotypes by altering the ER-dependent transcriptome. We further show that IL-8, one of the top altered FOXA1/ER effectors, plays a key role in mediating these phenotypes and is a potential target to treat ER+/FOXA1-high breast cancer. Our findings provoke a new interplay of FOXA1 in the ER transcriptional program in endocrine-resistant breast cancer.
Russia as the other
Authors: Bolshakova Anastasia 
Published: October 2016

AbstractThis paper explores the construction of Russia as the Other in a major Western media source. For its theoretical framework, it draws on Stuart Hall’s conception of the representation of the Other through splitting. The study is based on the comparative analysis of the portrayal of Russia and the UK as host nations for two different Olympic Games inThe New York Times. In order to reduce researcher bias, the analysis is conducted using methods of corpus linguistics. Two specialized corpora were compiled: one on the run-up to the 2014 Sochi Olympics and the other to the 2012 London Olympics. Three topics of the typical pre-Olympic discourse are compared: security, construction, and protests. It is observed that these aspects are constructed in binary opposition in the coverage of the two Games, presenting Russia as the West’s constituting Other. The issue of the negative implications of such discourse is raised.
Global spread of chikungunya virus: a lesson for
Aedes
-transmitted arboviruses?
Authors: Santos C. N. D. dos , Dupont-Rouzeyrol M. , Sam I. C. , Roques P. 
Published: October 2016

Abstract

Chikungunya virus (CHIKV) is an arbovirus, transmitted by
Aedes aegypti
and
Ae. albopictus
, which causes epidemics of fever, rash and joint pains. First described in 1952 in Tanzania, CHIKV remained a relatively neglected tropical virus, despite causing sporadic outbreaks in Africa and Asia over the next few decades. However, since 2004, an epidemic lineage of the East/Central/South African (ECSA) genotype has arisen in East Africa and spread to cause unprecedented global outbreaks in the Indian Ocean islands, South and Southeast Asia, as well as autochthonous outbreaks in Europe. This spread was driven by mutations in the virus envelope proteins that improved the vectorial competence of
Ae. albopictus
, which is widely distributed in the affected areas, and which was previously considered a vector of secondary importance to
Ae. aegypti
. In 2011, the Asian lineage of CHIKV emerged to cause outbreaks in Pacific islands, before unexpectedly spreading to cause explosive epidemics in the Caribbean and Latin America, mainly via
Ae. aegypti
. The factors behind the global spread of previously niche arboviruses such as CHIKV and more recently Zika virus are complex, multifactorial and poorly understood. The implications on strained health services and economies are considerable, particularly as CHIKV is associated with long-term rheumatological disorders. However, with the increasing ease of global travel and the growing geographical distributions of
Aedes
mosquito vectors, we should expect further spread of exotic arboviruses to new populations who remain entirely immunologically naive.
Influence of Introduction History on Genetic Variation in Introduced Populations: A Case Study of Oregon Chub
Authors: DeHaan Patrick W. , Adams Brice A. , Scheerer Paul D. , Bangs Brian L. 
Published: October 2016

Abstract
Population introductions and reintroductions have become a common tool for conserving threatened species, but oftentimes introduced populations have reduced the genetic diversity compared with the source population they were founded from. Population introductions played an important role in the recovery of the Oregon Chub Oregonichthys crameri, a small floodplain minnow found in western Oregon. Unlike many introduction efforts, introduced populations of Oregon Chub were founded using large numbers of individuals (hundreds in many cases) and each population had a unique introduction history (e.g., number of founders, source populations selected, duration of the introduction effort). We used microsatellite loci to examine 13 introduced populations and their respective sources to evaluate how well the introduction program captured genetic diversity present in the wild populations. Genetic variation was reduced by roughly 25% in one introduced population, and three introduced populations showed evidence of a genetic bottleneck due to heterozygote excess. Populations introduced from multiple sources had greater genetic diversity than populations from a single source. When multiple source populations were used, all source populations contributed genetic material to the introduced population, though the proportional contribution from each source population varied. Using correlation analyses and general linear models, we explored the relationship between introduction history variables and genetic diversity. Our top-ranked models included genetic diversity in the source population, and this variable had the highest variable importance weight (0.999), but the number of founders and the number of source populations were also important. Overall, the Oregon Chub introduction program was highly successful at capturing the genetic variation observed in natural populations. Results of this study will be useful for planning future population introductions for Oregon Chub and other species of conservation concern.
Received November 9, 2015; accepted June 18, 2016 Published online October 7, 2016
Colonial Waterbird Predation on Lost River and Shortnose Suckers in the Upper Klamath Basin
Authors: Evans Allen F. , Hewitt David A. , Payton Quinn , Cramer Bradley M. , Collis Ken , Roby Daniel D. 
Published: October 2016

Abstract
We evaluated predation on Lost River Suckers Deltistes luxatus and Shortnose Suckers Chasmistes brevirostris by American white pelicans Pelecanus erythrorhynchos and double-crested cormorants Phalacrocorax auritus nesting at mixed-species colonies in the Upper Klamath Basin of Oregon and California during 2009–2014. Predation was evaluated by recovering (detecting) PIT tags from tagged fish on bird colonies and calculating minimum predation rates, as the percentage of available suckers consumed, adjusted for PIT tag detection probabilities but not deposition probabilities (i.e., probability an egested tag was deposited on- or off-colony). Results indicate that impacts of avian predation varied by sucker species, age-class (adult, juvenile), bird colony location, and year, demonstrating dynamic predator–prey interactions. Tagged suckers ranging in size from 72 to 730 mm were susceptible to cormorant or pelican predation; all but the largest Lost River Suckers were susceptible to bird predation. Minimum predation rate estimates ranged annually from &lt;0.1% to 4.6% of the available PIT-tagged Lost River Suckers and from &lt;0.1% to 4.2% of the available Shortnose Suckers, and predation rates were consistently higher on suckers in Clear Lake Reservoir, California, than on suckers in Upper Klamath Lake, Oregon. There was evidence that bird predation on juvenile suckers (species unknown) in Upper Klamath Lake was higher than on adult suckers in Upper Klamath Lake, where minimum predation rates ranged annually from 5.7% to 8.4% of available juveniles. Results suggest that avian predation is a factor limiting the recovery of populations of Lost River and Shortnose suckers, particularly juvenile suckers in Upper Klamath Lake and adult suckers in Clear Lake Reservoir. Additional research is needed to measure predator-specific PIT tag deposition probabilities (which, based on other published studies, could increase predation rates presented herein by a factor of roughly 2.0) and to better understand biotic and abiotic factors that regulate sucker susceptibility to bird predation.
Received January 19, 2016; accepted June 25, 2016 Published online October 7, 2016
Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma
Authors: Franco Valentina , Marchiselli Roberto , Fattore Cinzia , Tartara Elena , De Sarro Giovambattista , Russo Emilio , Perucca Emilio 
Published: October 2016

Background:
Perampanel, a new specific non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist, has been recently approved in the United States and the European Union for the adjunctive treatment of focal seizures and primary generalized tonic–clonic seizures associated with idiopathic generalized epilepsy. A positive relationship between plasma perampanel concentration and improvement in seizure control has been identified in regulatory trials, suggesting that therapeutic drug monitoring could be useful in optimizing clinical response in patients with epilepsy treated with perampanel. The development of a simple and broadly applicable method for measuring plasma perampanel concentrations is desirable to permit the use of TDM for this drug in clinical practice.

Methods:
A high-performance liquid chromatographic method with ultraviolet detection for the quantitative determination of perampanel in small aliquots of human plasma (200 μL) has been developed and validated. Sample preparation involves a simple precipitation step followed by solvent evaporation. High-performance liquid chromatographic separation is achieved on 2 reverse-phase monolithic columns in sequence connected to an ultraviolet detector (320 nm), using as mobile phase water/acetonitrile (60:40 vol/vol) mixed with 1 mL/L phosphoric acid, at a flow rate of 1.5 mL/min. Promethazine hydrochloride is used as internal standard.

Results:
Calibration curves were linear over a perampanel concentration range of 25–1000 ng/mL, with correlation coefficients equal or greater than 0.998 ± 0.001 and a limit of quantitation set at 25 ng/mL. Intra- and inter-day coefficients of variation did not exceed 7.4%, and the accuracy ranged from 96.4% to 113.3%. No interference was observed from commonly coprescribed drugs.

Conclusions:
The present assay is simple, specific, and cost effective with performance characteristics suitable for TDM use.
Cutaneous Leishmaniasis Successfully Treated by Liposomal Amphotericin B
Authors: Shah Niel N. , Nanjappa Sowmya , Messina Jane I. , Greene John N. 
Published: October 2016

Abstract
Leishmaniasis is a group of vector-borne diseases, caused by a group of protozoa belonging to the genus Leishmania. It is usually transmitted by sandfly vectors. There are 2 types of leishmaniasis: visceral and cutaneous. We report a case of cutaneous leishmaniasis in a young male caused by Leishmania panamensis. We also discuss the clinical features, diagnostic tools, differential diagnosis, and management options for cutaneous leishmaniasis.
Factors Associated With Antidepressant Dosing in Asia
Authors: Rajaratnam Kamini , Xiang Yu-Tao , Tripathi Adarsh , Chiu Helen Fung Kum , Si Tian-Mei , Chee Kok-Yoon , Avasthi Ajit , Grover Sandeep , Chong Mian-Yoon , Kuga Hironori , Kanba Shigenobu , He Yan-Ling , Lee Min-Soo , Yang Shu-Yu , Udomratn Pichet , Kallivayalil Roy Abraham , Tanra Andi J. , Maramis Margarita , Shen Winston Wu-Dien , Sartorius Norman , Kua Ee-Heok , Tan Chay-Hoon , Mahendran Rathi , Shinfuku Naotaka , Sum Min Yi , Baldessarini Ross J. , Sim Kang 
Published: October 2016

Abstract
In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120–129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.
Subjective Versus Objective Weight Gain During Acute Treatment With Second-Generation Antipsychotics in Schizophrenia and Bipolar Disorder
Authors: Gao Keming , Fang Fang , Wang Zuowei , Calabrese Joseph R. 
Published: October 2016

Objectives
To compare objective and subjective weight gain of second-generation antipsychotics in schizophrenia and bipolar disorder.

Methods
English-language literature published and cited in PubMed (MEDLINE) from January 1966 to December 2015 was searched with the keywords antipsychotic, atypical antipsychotic, or generic/brand name of atypical antipsychotics, and schizophrenia, bipolar disorder, bipolar mania, or bipolar depression, and safety, tolerability, weight gain, and randomized, placebo-controlled clinical trials. The absolute risk increases and the numbers needed to treat to harm (NNH) for ≥7% weight gain (objective) and self-report weight gain (subjective) were estimated.

Results
In schizophrenia, the NNH for 7% or greater weight gain ranged from 5 to 62, and the NNH for self-reported weight gain was from 11 to −224. The ratio of self-reported NNH to 7% or greater NNH was from 1.5 to 8.0. In bipolar mania, the NNH for 7% or greater weight gain ranged from 7 to −101 and the NNH for self-reported weight gain was from 13 to 84. The ratio of self-reported NNH to 7% or greater NNH was from 0.9 to 2.5. In bipolar depression, the NNH for 7% or greater weight gain ranged from 5 to 69, and the NNH for self-reported weight gain was from 8 to 17. The ratio of self-reported NNH to 7% or greater NNH was 1.2 to 1.6.

Conclusions
Subjective reporting underestimated the risk of antipsychotic-related weight gain compared with objectively measured weight change. Self-awareness of antipsychotic-related weight gain was lower in patients with schizophrenia than in patients with bipolar disorder. Measuring weight change during antipsychotic treatment should be a routine practice.
A Narrative Review of How Sleep-Related Breathing Disorders and Cardiovascular Diseases Are Linked
Authors: Moon Chooza , Phelan Cynthia H. , Lauver Diane R. , Bratzke Lisa C. 
Published: October 2016

Purpose/Objectives:
Sleep-related breathing disorders (SRBDs), including obstructive sleep apnea and central sleep apnea, are common among patients with cardiovascular disease (CVD), but clinicians often do not pay enough attention to SRBDs. The purpose of this narrative review is to update advanced practice registered nurses on the literature focusing on the relationship between SRBDs and CVD (eg, hypertension, heart failure, coronary artery disease, arrhythmias, and stroke) and on treatments that can improve SRBDs in patients with CVD.

Description of the Project:
We conducted an electronic search of the literature published between 1980 and 2016 from PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Academic Search Premier, and related health resource Web sites to address the aims of this study.

Outcomes:
Fifty-six primary research articles (42 observational studies and 14 experimental and quasi-experimental studies) were selected based on our study aims and inclusion criteria. The studies revealed that individuals with CVD are at a greater risk for SRBDs and that SRBDs can worsen CVD. The findings from the studies also suggest that positive airway treatment could improve both SRBDs and CVD.

Conclusions:
This review found a close relationship between SRBDs and CVD. Advanced practice registered nurses are in key positions to identify and help patients manage SRBDs. In particular, advanced practice registered nurses can educate staff and establish standards of practice to improve outcomes for patients with CVD.
Improving Effectiveness and Satisfaction of an Electronic Charting System in Taiwan
Authors: Hsieh Hsiao-Yen , Henker Richard , Ren Dianxu , Chien Wan-Yi , Chang Jia-Ping , Chen Lifan , Tuite Patricia K. 
Published: October 2016

Purpose/Objectives:
An efficient but comprehensive documentation system is essential for reducing nursing workload and ensuring adequate time for direct patient care. A “focus” is a nursing diagnosis or patient problem. The purpose of this project is to review and revise the focuses in the electronic charting system and to develop new focuses for documentation of clinical pathways. In addition, this project evaluated the impact of these changes on time required for documentation and nurse satisfaction.

Background/Rationale:
In 2012, a large hospital in Taiwan implemented a self-developed electronic charting system that had 217 focuses in the database. Staff reported low job satisfaction and too much time on documentation. Three major issues were identified, including repetitious and redundant documentation, incorrect templates, and an incomprehensive database.

Description:
A clinical nurse specialist devised quality improvement project was implemented on one 50-bed surgical unit. Forty-one focuses were revised and 13 new focuses were developed for clinical pathways. The implementation of new focus templates enhanced evidence-based practice and prevented redundant documentation. Focus templates also incorporated nursing policies and/or patient education materials. Two outcome indicators, time spent documenting and nurse satisfaction, were evaluated 3 months after implementation.

Outcomes:
Documentation time decreased by 60% (from 138.5 to 55.8 hours) per week. The median documentation time per patient per day decreased from 18.4 minutes to 9.3 minutes. Average scores for satisfaction in usability, content, functionality, and effectiveness were increased.

Conclusion:
Evidence-based focus templates used for documentation can reduce documentation time and increase nurse satisfaction. Clinical nurse specialists play an important role in leading the development of quality improvement projects while improving work efficiency.