bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilidad de la estimulación continua del núcleo pedunculopontino para el tratamiento de la enfermedad de Parkinson
Authors: Barbosa Balaguera Sthepany , Borda Miguel German , Zorro Oscar , Acevedo González Juan Carlos 
Published: December 2017

<p><strong>Resumen</strong></p><p>El núcleo pedunculopontino contiene gran cantidad de conexiones que modulan la actividad motora en los humanos; por este motivo, se ha planteado que su estimulación profunda tendría beneficios significativos en el tratamiento de la enfermedad de Parkinson. Con una carga orgánica y social significativa, la enfermedad de Parkinson reúne una serie de signos y síntomas, principalmente motores, que afectan significativamente la calidad de vida de los pacientes que la padecen. Actualmente, se encuentran dentro de un área de investigación con gran potencial para dar manejo a los síntomas de esta enfermedad, y se desconoce si su estimulación cerebral profunda podría orientar futuras intervenciones con resultados óptimos. Por esta razón, la revisión busca esclarecer la utilidad de este procedimiento; sin embargo, es bastante controvertido y su evidencia escasa, además de que es difícil centrarse únicamente en un núcleo para resolver los problemas relacionados con dicha enfermedad. </p>
Transición epitelio mesénquima: de lo molecular a lo fisiológico
Authors: Troncoso Daniela , Madariaga Perpiñan Ithzayana , Aldana Mancera Sergio Andrés , Herreño Pachón Angélica María , Chaparro Ramírez Viviana Paola , Molina Camargo Mónica Lorena , Rey Vargas Laura , Ramírez Rodríguez Andrea Carolina , Montoya Estupiñan Christian Fernando , Valderrama Álvarez Andrea , Cañas Arboleda Alejandra , Rojas Moreno Adriana Patricia 
Published: December 2017

<p><strong>Resumen </strong></p><p>La transición epitelio mesénquima (EMT) es un proceso compuesto de diferentes fases, donde una célula epitelial adquiere un fenotipo mesenquimal. Dentro de los cambios involucrados se encuentran: pérdida de la polaridad celular, adquisición de una capacidad migratoria, capacidad invasora, resistencia a la apoptosis y aumento en la producción de componentes de la matriz extracelular. Todos estos cambios ocurren como una consecuencia de la activación y represión de genes involucrados con rutas de señalización específicas relacionadas con este evento. La EMT está relacionada con procesos fisiológicos y patológicos como el cáncer. Consta de tres fases: una de células no migratorias, células premigratorias y células migratorias; cada una de ellas producto de diferentes señales intra o extracelulares, factores de transcripción (TGF-B, Snail, TWIST, Sox, Slug, ZEB1, entre otras) y proteínas involucradas (E-cadherina, integrina, vimentina, ocludinas y claudinas). </p>
Evolution and Diversity of Inherited Spiroplasma Symbionts in Myrmica Ants
Authors: Ballinger Matthew J. , Moore Logan D. , Perlman Steve J. 
Published: December 2017

ABSTRACT

Microbial partners play important roles in the biology and ecology of animals. In insects, maternally transmitted symbionts are especially common and can have host effects ranging from reproductive manipulation to nutrient provisioning and defense against natural enemies. In this study, we report a genus-wide association of
Myrmica
ants with the inherited bacterial symbiont
Spiroplasma
. We screen
Myrmica
ants collected from the wild, including the invasive European fire ant,
Myrmica rubra
, and find an extraordinarily high prevalence of this symbiont—8 of 9 species, 42 of 43 colonies, and 250 of 276 individual workers harbored
Spiroplasma
—only one host species was uninfected. In our screens, each host species carried a distinct
Spiroplasma
strain, and none were infected with more than one strain. All symbionts belong to the
citri
clade, allied most closely with pathogenic strains of
Spiroplasma
infecting corn crops and honeybees, and there is strong evidence of host-symbiont persistence across evolutionary time scales. Genome sequencing of two
Spiroplasma
symbionts revealed candidate genes that may play a part in the symbiosis, a nutrient transporter absent from other
Spiroplasma
strains, and a ribosome-inactivating protein previously implicated in parasite defense. These results together suggest long-term, likely mutualistic, relationships atypical of
Spiroplasma
-insect associations with potential significance for broad ecological interactions with
Myrmica
.

IMPORTANCE
Animal-associated microbial symbionts can dramatically affect the biology of their hosts. The identification and characterization of these intimate partnerships remain an essential component of describing and predicting species interactions, especially for invasive host species. Ants perform crucial ecological functions as ecosystem engineers, scavengers, and predators, and ants in the genus
Myrmica
can be aggressive resource competitors and reach high densities in their native and invaded habitats. In this study, a novel symbiosis is identified between
Myrmica
ants and the facultative bacterial symbiont
Spiroplasma
. Broad host distribution, high frequencies of infection, and host-symbiont codivergence over evolutionary time scales, an uncommon feature of
Spiroplasma
associations, suggest an important likely mutualistic interaction. Genome sequencing identified highly divergent gene candidates that may contribute to
Spiroplasma
's role as a possible defensive or nutritional partner in
Myrmica
.
Complete Genome Sequence of Bacillus vallismortis NBIF-001, a Novel Strain from Shangri-La, China, That Has High Activity against Fusarium oxysporum
Authors: Liu Xiaoyan , Min Yong , Huang Daye , Zhou Ronghua , Fang Wei , Liu Cuijun , Rao Ben , Zhang Guangyang , Wang Kaimei , Yang Ziwen 
Published: December 2017

ABSTRACT

Bacillus vallismortis
NBIF-001, a Gram-positive bacterium, was isolated from soil in Shangri-La, China. Here, we provide the complete genome sequence of this bacterium, which has a 3,929,787-bp-long genome, including 4,030 protein-coding genes and 195 RNA genes. This strain possesses a number of genes encoding virulence factors of pathogens.
Two Draft Genome Sequences of
Sphingobacterium
sp. Strains Isolated from Honey
Authors: Veress Alexandra , Wilk Tímea , Kiss János , Papp Péter P. , Olasz Ferenc 
Published: December 2017

ABSTRACT

Here, we report two annotated draft genome sequences of
Sphingobacterium
sp. strains isolated from honey. The genomes of strains 1.A.4 and 1.A.5 show a limited similarity to each other and to genomes of other
Sphingobacterium
species, indicating that these isolates may represent new species.
Changes in older people’s care profiles during the last 2 years of life, 1996–1998 and 2011–2013: a retrospective nationwide study in Finland
Authors: Aaltonen Mari , Forma Leena , Pulkki Jutta , Raitanen Jani , Rissanen Pekka , Jylha Marja 
Published: December 2017

ObjectivesThe time of death is increasingly postponed to a very high age. How this change affects the use of care services at the population level is unknown. This study analyses the care profiles of older people during their last 2 years of life, and investigates how these profiles differ for the study years 1996–1998 and 2011–2013.DesignRetrospective cross-sectional nationwide data drawn from the Care Register for Health Care, the Care Register for Social Care and the Causes of Death Register. The data included the use of hospital and long-term care services during the last 2 years of life for all those who died in 1998 and in 2013 at the age of ≥70 years in Finland.MethodsWe constructed four care profiles using two criteria: (1) number of days in round-the-clock care (vs at home) in the last 2 years of life and (2) care transitions during the last 6 months of life (ie, end-of-life care transitions).ResultsBetween the study periods, the average age at death and the number of diagnoses increased. Most older people (1998: 64.3%, 2013: 59.3%) lived at home until their last months of life (profile 2) after which they moved into hospital or long-term care facilities. This profile became less common and the profiles with a high use of care services became more common (profiles 3 and 4 together in 1998: 25.0%, in 2013: 30.9%). People with dementia, women and the oldest old were over-represented in the latter profiles. In both study periods, fewer than one in ten stayed at home for the whole last 6 months (profile 1).ConclusionsPostponement of death to a very old age may translate into more severe disability in the last months or years of life. Care systems must be prepared for longer periods of long-term care services needed at the end of life.
Do changing levels of maternal exercise during pregnancy affect neonatal adiposity? Secondary analysis of the babies after SCOPE: evaluating the longitudinal impact using neurological and nutritional endpoints (BASELINE) birth cohort (Cork, Ireland)
Authors: Norris Tom , McCarthy Fergus P , Khashan Ali S , Murray Deidre M , Kiely Mairead , Hourihane Jonathan O’B , Baker Philip N , Kenny Louise C 
Published: December 2017

ObjectiveTo investigate whether changing levels of exercise during pregnancy are related to altered neonatal adiposity.DesignSecondary analysis of data from a prospective cohort study.SettingCork, Ireland.Participants1200 mother–infant pairs recruited as part of a prospective birth cohort, Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE).Main outcome measuresNeonatal adiposity was assessed within several days of birth using air displacement plethysmography (PEAPOD). Per cent body fat (BF%) as a continuous outcome and a pair of dichotomous variables; high or low adiposity, representing BF% >90th or <10th centile, respectively. Multivariable linear and logistic regression models were used to investigate the relationship between exercise and the respective outcomes.ResultsCrude analysis revealed no association between a changing level of exercise (since becoming pregnant) at 15 weeks’ gestation and any of the outcomes (BF%, low adiposity and high adiposity). At 20 weeks’ gestation, analyses revealed that relative to women who do not change their exercise level up to 20 weeks, those women who decreased their exercise level were more likely to give birth to a neonate with adiposity above the 90th centile (OR 1.62, 95% CI 1.07 to 2.46). This association was maintained after adjustment for putative confounders (OR 1.62, 95% CI 1.06 to 2.47).ConclusionsWe observed a possible critical period for the association between changing exercise levels and neonatal adiposity, with no association observed with exercise recall for the first 15 weeks of gestation, but an association with a decreasing level of exercise between 15 and 20 weeks. These results should be interpreted in line with the limitations of the study and further studies utilising objectively measured estimates of exercise are required in order to replicate these findings.Trial registration numberNCT01498965.
Partners at Care Transitions (PACT)—exploring older peoples’ experiences of transitioning from hospital to home in the UK: protocol for an observation and interview study of older people and their families to understand patient experience and involvement in care at transitions
Authors: Hardicre Natasha Kate , Birks Yvonne , Murray Jenni , Sheard Laura , Hughes Lesley , Heyhoe Jane , Cracknell Alison , Lawton Rebecca 
Published: December 2017

IntroductionLength of hospital inpatient stays have reduced. This benefits patients, who prefer to be at home, and hospitals, which can treat more people when stays are shorter. Patients may, however, leave hospital sicker, with ongoing care needs. The transition period from hospital to home can be risky, particularly for older patients with complex health and social needs. Improving patient experience, especially through greater patient involvement, may improve outcomes for patients and is a key indicator of care quality and safety. In this research, we aim to: capture the experiences of older patients and their families during the transition from hospital to home, and identify opportunities for greater patient involvement in care, particularly where this contributes to greater individual-level and organisational-level resilience.Methods and analysisA ‘focused ethnography’ comprising observations, ‘Go-Along’ and semistructured interviews will be used to capture patient and carer experiences during different points in the care transition from admission to 90 days after discharge. We will recruit 30 patients and their carers from six hospital departments across two National Health Service (NHS) Trusts. Analysis of observations and interviews will use a framework approach to identify themes to understand the experience of transitions and generate ideas about how patients could be more actively involved in their care. This will include exploring what ‘good’ care at transitions looks like and seeking out examples of success, as well as recommendations for improvement.Ethics and disseminationEthical approval was received from the NHS Research Ethics Committee in Wales. The research findings will add to a growing body of knowledge about patient experience of transitions, in particular providing insight into the experiences of patients and carers throughout the transitions process, in ‘real time’. Importantly, the data will be used to inform the development of a patient-centred intervention to improve the quality and safety of transitions.
Multiple and multidimensional transitions from trainee to trained doctor: a qualitative longitudinal study in the UK
Authors: Gordon Lisi , Jindal-Snape Divya , Morrison Jill , Muldoon Janine , Needham Gillian , Siebert Sabina , Rees Charlotte 
Published: December 2017

ObjectivesTo explore trainee doctors’ experiences of the transition to trained doctor, we answer three questions: (1) What multiple and multidimensional transitions (MMTs) are experienced as participants move from trainee to trained doctor? (2) What facilitates and hinders doctors’ successful transition experiences? (3) What is the impact of MMTs on trained doctors?DesignA qualitative longitudinal study underpinned by MMT theory.SettingFour training areas (health boards) in the UK.Participants20 doctors, 19 higher-stage trainees within 6 months of completing their postgraduate training and 1 staff grade, associate specialist or specialty doctor, were recruited to the 9-month longitudinal audio-diary (LAD) study. All completed an entrance interview, 18 completed LADs and 18 completed exit interviews.MethodsData were analysed cross-sectionally and longitudinally using thematic Framework Analysis.ResultsParticipants experienced a multiplicity of expected and unexpected, positive and negative work-related transitions (eg, new roles) and home-related transitions (eg, moving home) during their trainee–trained doctor transition. Factors facilitating or inhibiting successful transitions were identified at various levels: individual (eg, living arrangements), interpersonal (eg, presence of supportive relationships), systemic (eg, mentoring opportunities) and macro (eg, the curriculum provided by Medical Royal Colleges). Various impacts of transitions were also identified at each of these four levels: individual (eg, stress), interpersonal (eg, trainees’ children spending more time in childcare), systemic (eg, spending less time with patients) and macro (eg, delayed start in trainees’ new roles).ConclusionsPriority should be given to developing supportive relationships (both formal and informal) to help trainees transition into their trained doctor roles, as well as providing more opportunities for learning. Further longitudinal qualitative research is now needed with a longer study duration to explore transition journeys for several years into the trained doctor role.
Application of time series analysis in modelling and forecasting emergency department visits in a medical centre in Southern Taiwan
Authors: Juang Wang-Chuan , Huang Sin-Jhih , Huang Fong-Dee , Cheng Pei-Wen , Wann Shue-Ren 
Published: December 2017

ObjectiveEmergency department (ED) overcrowding is acknowledged as an increasingly important issue worldwide. Hospital managers are increasingly paying attention to ED crowding in order to provide higher quality medical services to patients. One of the crucial elements for a good management strategy is demand forecasting. Our study sought to construct an adequate model and to forecast monthly ED visits.MethodsWe retrospectively gathered monthly ED visits from January 2009 to December 2016 to carry out a time series autoregressive integrated moving average (ARIMA) analysis. Initial development of the model was based on past ED visits from 2009 to 2016. A best-fit model was further employed to forecast the monthly data of ED visits for the next year (2016). Finally, we evaluated the predicted accuracy of the identified model with the mean absolute percentage error (MAPE). The software packages SAS/ETS V.9.4 and Office Excel 2016 were used for all statistical analyses.ResultsA series of statistical tests showed that six models, including ARIMA (0, 0, 1), ARIMA (1, 0, 0), ARIMA (1, 0, 1), ARIMA (2, 0, 1), ARIMA (3, 0, 1) and ARIMA (5, 0, 1), were candidate models. The model that gave the minimum Akaike information criterion and Schwartz Bayesian criterion and followed the assumptions of residual independence was selected as the adequate model. Finally, a suitable ARIMA (0, 0, 1) structure, yielding a MAPE of 8.91%, was identified and obtained as Visitt=7111.161+(at+0.37462 at−1).ConclusionThe ARIMA (0, 0, 1) model can be considered adequate for predicting future ED visits, and its forecast results can be used to aid decision-making processes.
Validation of the grown-ups with congenital heart disease score
Authors: Hörer Jürgen , Roussin Régine , LeBret Emanuel , Ly Mohamed , Abdullah Jarrah , Marzullo Rafaella , Pabst von Ohain Jelena , Belli Emre 
Published: December 2017

ObjectivesAdults with congenital heart disease in need of heart surgery frequently present with significant comorbidity. Furthermore, additional technical difficulties often related to redo operations increase the risk for postoperative mortality and morbidity. Hence, next to the type of the procedure, additional procedure-dependent and procedure-independent factors have to be considered for risk evaluation. The recently proposed grown-ups with congenital heart disease (GUCH) mortality and morbidity scores account for these additional risk factors. We sought to validate their predictive power in a large population operated in a single centre.MethodsData of all consecutive patients aged 18 years or more, who underwent surgery for congenital heart disease between 2005 and 2016, were collected. Mortality was defined as hospital mortality or mortality within 30 days following surgery. Morbidity was defined as occurrence of one or more of the following complications: renal failure requiring dialysis, neurologic deficit persisting at discharge, atrioventricular block requiring permanent pacemaker implantation, mechanical circulatory support, phrenic nerve injury and unplanned reoperation. The discriminatory power of the GUCH scores was assessed using the area under the receiver operating characteristics curve (c-index, including 95% CI).ResultsEight hundred and twenty-four operations were evaluated. Additional procedure-dependent and procedure-independent factors, as defined in the GUCH scores, were present in 165 patients (20.0%) and 544 patients (66.0%), respectively. Hospital mortality and morbidity was 3.4% and 10.0%, respectively. C-index for GUCH mortality score was 0.809 (0.742–0.877). C-index for GUCH morbidity score was 0.676 (0.619–0.734).ConclusionsWe could confirm the good predictive power of the GUCH mortality score for postoperative mortality in a large population of adults with congenital heart disease.
RaTrace: simple and efficient abstractions for BVH ray traversal algorithms
Authors: Pérard-Gayot Arsène , Weier Martin , Membarth Richard , Slusallek Philipp , Leißa Roland , Hack Sebastian 
Published: December 2017

In order to achieve the highest possible performance, the ray traversal and intersection routines at the core of every high-performance ray tracer are usually hand-coded, heavily optimized, and implemented separately for each hardware platform—even though they share most of their algorithmic core. The results are implementations that heavily mix algorithmic aspects with hardware and implementation details, making the code non-portable and difficult to change and maintain.
In this paper, we present a new approach that offers the ability to define in a functional language a set of conceptual, high-level language abstractions that are optimized away by a special compiler in order to maximize performance. Using this abstraction mechanism we separate a generic ray traversal and intersection algorithm from its low-level aspects that are specific to the target hardware. We demonstrate that our code is not only significantly more flexible, simpler to write, and more concise but also that the compiled results perform as well as state-of-the-art implementations on any of the tested CPU and GPU platforms.
Abstract A15: The relationship between cervical cancer associated genes and human papilloma viruses in rural Africans in Zaria
Authors: Idoko John , Faruk Mohammed , Yaro Jigo Dangude , Enemari James Oluwa , Akpulu Peter 
Published: December 2017

Abstract
Cervical cancer is a major public health problem and one of the leading gynecological cancers in developing nations. Reports from Nigeria, the largest black nation in the world by population, show that the national incidence of cervical cancer is 250/100,000. We sought to evaluate the relationship between cervical cancer associated genes and human papilloma viruses from rural Africans in Zaria, Nigeria using immunohistochemistry and molecular phylogenetics. Selected cervical cancer associated genes sequences which include Ki-67 (NM_002417.4), p53 (AB082923.1), EGFR (NM_005228.3), MYC (M25803.1), KRAS (EF471957.1), TGF-B (AF254794.1) and RB (AH002963.2) genes and HPV 16 (KJ869425.1 E6 and E7 variants), HPV 18 (KJ869426.1), HPV 45 (S40261.1), HPV 6 (A25369.1), HPV 11 (J04351.1), HPV 31 (KJ869427.1) and HPV 33 (KJ869428.1) sequences were retrieved from the gene bank data base. The sequences were aligned and bootstrap at 2000 bp to create a molecular phylogenetic tree. Haematoxylin and Eosin together with immunohistochemistry were performed on fifty formalin-fixed paraffin-embedded (FFPE) tissue blocks using Anti- Ki-67, p53, EGFR, MYC, KRAS, TGF-B and RB monoclonal antibodies. Result from the phylogenetic analysis reveals trichotomized tree showing apparent significant evolutionary relationship between cladogram of HPV16 and MYC; HPV18, HPV6 and KRAS genes; EGFR gene and HPV45. Immunohistochemistry results show multivariate expression of Ki-67, p53, EGFR, MYC, KRAS, TGF-B and RB of proteins from the cervical cancer tissue blocks used. Combination of Ki-67 biomarker and other cervical cancer associated genes together with HPV subtypes-genotyping can serve as useful instruments in proper management of the disease.
Citation Format: John Idoko, Mohammed Faruk, Jigo Dangude Yaro, James Oluwa Enemari, Peter Akpulu. The relationship between cervical cancer associated genes and human papilloma viruses in rural Africans in Zaria [abstract]. In: Proceedings of the AACR International Conference: New Frontiers in Cancer Research; 2017 Jan 18-22; Cape Town, South Africa. Philadelphia (PA): AACR; Cancer Res 2017;77(22 Suppl):Abstract nr A15.