bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric disorders among survivors of childhood acute lymphoblastic leukemia in Denmark and Sweden
Authors: Sørensen Gitte V. , Mogensen Hanna , Holmqvist Anna S. , Kenborg Line , Pedersen Camilla , Nielsen Thomas T. , Talbäck Mats , Erdmann Friederike , Ifversen Marianne , Feychting Maria , Schmiegelow Kjeld , Heyman Mats M. , Winther Jeanette F. , Hasle Henrik , Frederiksen Line E. 
Published: October 2024

AbstractBackgroundThe diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) may impact mental health. We investigated the long‐term risk of psychiatric disorders among survivors of ALL in a population‐based cohort study.MethodsWe identified patients diagnosed with ALL in Denmark and Sweden before age 20 during 1982–2008. Survivors of ALL (n = 2026), their siblings (n = 3027), and population comparison subjects (n = 9713) were followed for hospital contacts for psychiatric disorders from 5 years after ALL diagnosis (or corresponding index date) until 2017.ResultsBy age 30, the absolute risk of psychiatric hospital contacts was 19.9% (95% confidence interval [CI]: 17.9–22.1) for ALL survivors, 18.5% (95% CI: 16.9–20.2) for siblings, and 18.3% (95% CI: 17.3–19.2) for population comparison subjects. Overall, survivors were at higher risk of any psychiatric disorders than siblings (hazard ratio [HR] = 1.25; 95% CI: 1.04–1.50), and population comparison subjects (HR = 1.20; 95% CI: 1.06–1.35). The subgroup of survivors (n = 332) who received a hematopoietic stem cell transplantation (HSCT) and/or had a relapse were at highest risk of psychiatric disorders (HR = 2.07; 95% CI: 1.26–3.41 compared to siblings; HR = 1.67; 95% CI: 1.25–2.23 compared to population comparison subjects).ConclusionsThe overall absolute risk of psychiatric hospital contacts among ALL survivors was close to that in siblings and population comparison subjects. The modestly increased relative risk was mainly driven by the subgroup of survivors who received HSCT and/or had a relapse. Our findings are reassuring for the large subgroup of ALL survivors without HSCT or relapse, and provide novel insight on both absolute and relative risk of hospital contacts for psychiatric disorders.
A comparative in vivo study of hyperthermic intraperitoneal chemotherapy with cisplatin versus doxorubicin versus cisplatin plus doxorubicin for the treatment of intra‐abdominally disseminated alveolar rhabdomyosarcoma in mice
Authors: Martynov Illya , Gesche Jens , Dhaka Lajwanti , Tobi Luca , Hoyer Paul , Seitz Guido 
Published: October 2024

AbstractBackgroundTreatment options for advanced intra‐abdominal pediatric rhabdomyosarcoma (RMS) with peritoneal sarcomatosis (PS) include cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). However, optimal dosages and combination regimens of drugs used for HIPEC are underexplored. We aimed to evaluate the efficacy of HIPEC with cisplatin, doxorubicin, and their combination in vivo.MethodsWe established PS/RMS mouse model by intraperitoneally injecting RH30 cells into NOD/LtSz‐scid IL2Rγ‐null mice. Two weeks post xenotransplantation, mice underwent a single HIPEC procedure at 42°C for 60 minutes. Treatment groups received cisplatin (50, 100, and 150 mg/m2) and doxorubicin (30, 45, and 60 mg/m2), administered alone or combined. The control group underwent an intraperitoneal lavage with isotonic saline. Peritoneal cancer index (PCI) was used to quantify the extent of peritoneal tumor spread. Tissue samples were evaluated regarding proliferation (Ki‐67) and apoptosis (caspase 3).ResultsMice treated with cisplatin at 100 mg/m2 (PCI of 3.875, p = .007) and 150 mg/m2 (PCI of 4.556, p = .026), and doxorubicin at 30 mg/m2 (PCI of 2.875, p < .001) and 45 mg/m2 (PCI of 4.143, p = .021) showed reduced PCI, with the combination of cisplatin 50 mg/m2 and doxorubicin 30 mg/m2 showing the most prominent effect (PCI of 3.333, p < .001) compared to the control group (PCI of 8.615). Histologically, there was no difference in Ki‐67 or caspase 3 expression among the groups.ConclusionsThe cisplatin‐ and doxorubicin‐based HIPEC significantly reduces peritoneal tumor dissemination in vivo. Further investigations are needed to explore the underlying molecular responses to optimize therapeutic strategies.
Cross‐referenceable microscopic and micro‐spectroscopic analysis of fiber reinforced thermoplastics
Authors: Yoshida Yuki , Furushima Yoshitomo , Okino Shunnosuke , Mizaikoff Boris 
Published: October 2024

AbstractThis study aims at the assessment of damage on crystallinity of fiber reinforced thermoplastic (FRTP) composites resulting from mechanical polishing to demonstrate a novel methodology enabling comprehensive crystalline structural characterization. Investigating the crystalline structure is relevant for understanding the relationship with the mechanical properties. In a previous study, FRTPs have successfully been processed to the thickness of 5 μm or below via an innovative polishing strategy, which for the first time visualized the crystalline morphologies by polarized optical microscopy. Analyzing these sections via micro‐Raman and micro‐infrared spectroscopies facilitate the quantification of these structure. However, no study reports on the correct interpretation of FRTP data appropriately considering the damage resulting from mechanical polishing to date. Herein, we report fundamental knowledge on this aspect via detailed Raman micro‐spectroscopic investigations to demonstrate our novel strategy. Four types of FRTPs with major matrix resins (GF/PBT, CF/PA6, CF/PEEK and GF/PP) were analyzed and the damage on both polished cross‐sections, prepared by traditional process, and the thin sections was confirmed to be approx. 1%–2% crystallinity, which solidified the credibility of the obtained analytical data. Then, the newly established methodology of ‘cross‐referenceable microscopic and micro‐spectroscopic analyses for FRTPs’ was applied for comprehensive crystalline structural characterization.Highlights
Cross‐sectioning and thin‐sectioning of FRTPs.
Evidencing of damage on the crystallinity resulting from mechanical polishing.
Equations to convert Raman spectral data into crystallinity.
Strategy for considering the anisotropy of Raman measurements.
Practical application of novel microscopic and micro‐spectroscopic strategies.
Finite element analysis on the compression and crush responses of laminates with unidirectionally arrayed chopped strand in 0° plies
Authors: Lu Wenlong , Kong Yuxiang , Wang Jiaming , Huang Yinyuan , Li Minglong , Hu Junfeng 
Published: October 2024

AbstractThe outstanding mechanical performance and flowability of unidirectionally arrayed chopped strands laminates (UACS) give them an advantage in the manufacture of engineering structures with complex geometries. In this research, the mechanical response of UACS laminates with bi‐angled slits and staggered slits under quasi‐static compression and progressive crushing loads is numerically analyzed for the first time. The aim is to clarify the damage mechanism of UACS laminates under compressive and crushing load. Simulation results reveal that the compressive strength of [90/0]4s UACS laminates with bi‐angled slits is 635.9 MPa, with an error of 4.2% compared to experimental data. For the stacking sequence of [0/90]4s, the strength is measured as 581.96 MPa with a 5% error. Proposed finite element model could accurately describe the mechanical properties of UACS laminates. Additionally, the progressive crushing response is in good agreement with the experimental data, the error in energy absorption for [90/0]4s UACS laminates with bi‐angled slits is noted at 7% compared to experimental values. It has been demonstrated that bi‐angled slits significantly contribute in restraining the propagation of delamination and improving the amount of energy absorption of UACS laminates.Highlights
The mechanical response of UACS laminates under compressive and progressive crushing load was numerically analyzed.
The compressive damage propagation of UACS laminates with different slit patterns in 0° layer was demonstrated.
The effect of different slit patterns on inhibiting delamination propagation and increasing energy absorption of UACS laminates under progressive crushing load was numerically analyzed.
Interaction between tea consumption and genes on activities of daily living disability in older adults
Authors: Zou Min , Yang Mengxue , Zheng Dewei , Sun Changlong , Wang Jiali , Yuan Xiaoping , Li Changjiang , Yu Lirong , Sun Lina , Wang Yanyu , Chen Huashuai , Zeng Yi 
Published: October 2024

AbstractThe effects of tea consumption on delaying aging and the onset of age‐related disabilities have been reported; however, it is unclear whether these benefits are impacted by genes. This study aimed to examine the associations between tea consumption and activities of daily living (ADL) and explore the role of genetic factors. Data from 46,487 older adults aged 64–105 who participated in at least one data wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2002, 2005, 2008, 2011, 2014, and 2018 were analyzed. Genetic data were produced using the Affymetrix Axiom™myDesign™ (384‐format) Human Genotyping Array. The generalized estimation equation and multiple logistic regression models were constructed to examine the effects of tea consumption, polygenic risk score, and their interactions on ADL. Tea consumption was related to reduced ADL decline—the effect was statistically significant among men but not women. A significant interaction between tea consumption and polygenic risk score (PRS) was observed. Tea consumption was associated with a decreased risk of ADL disability only among individuals with a low PRS. These findings indicate that tea consumption plays a role in preventing disability in older adults with low polygenic risk.
Diversity of organic amendments increases soil functions and plant growth
Authors: Li Huiying , Lehmann Anika , Rongstock Rebecca , Xu Yaqi , Kunze Edda , Meidl Peter , Rillig Matthias C. 
Published: October 2024

Societal Impact StatementManagement practices, for example, in an agricultural context, are often tested in isolation or in pairwise interaction, but rarely using a higher number of jointly applied practices. In a proof‐of‐concept study, we test the effects of combining up to five management practices. Effects seen on soil and plant performance suggest that it may be worth to systematically and broadly examine the effects of higher order management combinations.
Nanoparticle delivery of VEGF and SDF‐1α as an approach for treatment of pulmonary arterial hypertension
Authors: Guarino Victoria A. , Wertheim Bradley M. , Xiao Wusheng , Loscalzo Joseph , Zhang Ying‐Yi 
Published: October 2024

AbstractEndothelial dysfunction is an underlying mechanism for the development of pulmonary arterial hypertension (PAH). Vascular endothelial growth factor (VEGF) and stromal cell‐derived factor‐1α (SDF) may help repair the dysfunctional endothelium and provide treatment for PAH. To examine this possibility, nanoparticles carrying human recombinant VEGF and SDF (VEGFNP and SDFNP) were aerosolized into the lungs of nude rats at Day 14 after monocrotaline (MCT) injection and analyses were performed at Day 28. The data show that the VEGFNP/SDFNP delivery led to a lower pulmonary arterial pressure and prevented right ventricular hypertrophy in the MCT rats: the right ventricular systolic pressure of the control, MCT, and MCT + VEGFNP/SDFNP treatment groups were 29±2, 70±9, and 44±5 (mean±SD) mmHg, respectively; the pulmonary vascular resistance indices of the groups were 0.6±0.3, 3.2±0.7, and 1.7±0.5, respectively; and the Fulton indices [−RV/(LV + Septum)] were 0.22±0.01, 0.44±0.07, and 0.23±0.02, respectively. The VEGFNP/SDFNP delivery delayed the thickening of distal pulmonary vessels: the number of nearly occluded vessels in a whole lung section from the MCT and MCT + VEGFNP/SDFNP groups were 46±12 and 2±3, respectively. Gene expression analysis of the endothelial cell markers, VE‐cadherin, KDR, BMPR2, and eNOS, and smooth cell markers, SM‐MHC and α‐SMA, indicated significant loss of distal pulmonary vessels in the MCT‐ treated rats. VEGFNP/SDFNP delivery did not recover the loss, but significantly increased eNOS and decreased α‐SMA expression in the MCT‐treated lungs. Thus, the therapeutic effect of VEGFNP/SDFNP may be mediated by improving/repairing endothelial function in the PAH lungs.
The Effects of Meander Reconnection and Deflector Installation on the Physicochemical Water Quality
Authors: Hons Malaurie , Maris Tom , Schoelynck Jonas 
Published: October 2024

ABSTRACTRiver restoration efforts are gaining momentum in response to the pressing need for resilient river systems, in light of escalating climate change impacts. However, achieving predefined restoration goals remains challenging due to insufficient understanding of river system responses. Of particular complexity is assessing the success of restoration measures on water quality, a critical abiotic factor in freshwater ecosystems. This study examined the impact of meander reconnection and deflector placement on water quality. Two distinct meander sections and a degraded section were meticulously sampled both upstream and downstream to assess impacts. The meander sections were reconnected using different approaches: one fully reconnected, receiving all discharge, and the other partially reconnected, receiving part of the discharge while maintaining the channelized trench. The results showed promising potential of reconnected meanders for mitigating phosphorus and carbon levels. However, the effectiveness of these improvements was compromised by deflector placement, which led to increased erosion and release of phosphorus bound to organic soil particles. Conversely, dissolved nutrients (e.g. nitrate, orthophosphate, DOC) exhibited no significant alterations, likely attributed to the absence of macrophytes and the limited extent of restorative actions, which currently do not increase water residence time sufficiently. Temporal trends revealed progressive reductions in carbon, phosphorus, and nitrogen levels suggesting that time is a crucial factor in restoration success, possibly due to soil stabilization. Seasonal dynamics also played a significant role, with discernible effects observed primarily during summer. This study underscores the importance of long‐term, watershed‐scale investigations that account for seasonal variability to fully understand the impacts of river restoration.
Electro‐Oxidation of Ibuprofen and Metoprolol Using a Manganese Oxide Platform
Authors: Lizzy Mokaba Pheladi , Msagati Titus A. M. , Nyoni Hlengilizwe , Mamba Bhekie B. , Feleni Usisipho 
Published: October 2024

AbstractPharmaceutical compounds, such as ibuprofen and metoprolol, are of increasing concern due to their persistence in the environment and potential adverse effects on human health. In this work, we developed an electrochemical sensor system for the determination of ibuprofen and metoprolol based on a modified manganese oxide nanoparticle (MnO2NPs) on a screen‐printed carbon electrode (SPCE). The characterisation of MnO2NPs modifier was investigated via Fourier transform infrared (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy techniques, Uv/vis spectroscopy, and small‐angle X‐ray scattering spectroscopy. The electrochemical behaviour of the MnO2NPs was studied using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) techniques. The optimum experimental conditions were investigated by examining the effects of scan rates, pH on the CV responses, and electrolytes on the DPV response. The MnO2NPs modified electrode demonstrated enhanced catalytic activity in the electro‐oxidation of both ibuprofen and metoprolol. The oxidation peaks of ibuprofen and metoprolol were observed at +1.14 V and +1.46 V, respectively, for the MnO2NPs/SPCE sensor. The sensor's limit of detection was 3.81 pM and 4.6 pM respectively and its linear response was from 0.97–5.82 pM. Furthermore, interference and stability studies were conducted to evaluate the performance of the MnO2NPs/SPCE sensor under optimum conditions, which resulted in a good performance. The proposed sensor was successfully used for the determination of ibuprofen and metoprolol in the application of real water samples.
Application of 28.1 kDa Alginate Oligosaccharide Improves the Yield and Quality of Grain in Rice
Authors: Samdurkar Anish N. , Choudhary Arvind D. , Varshney Lalit , Badere Rupesh S. 
Published: October 2024

AbstractWe conducted a phase‐wise study to evaluate the efficacy of the gamma ray‐produced oligosaccharides of alginate and chitosan in enhancing the yield in rice. Initially, we irradiated the dry powder of alginate and chitosan with 200–500 kGy dose of gamma ray to produce their oligosaccharides. Subsequently, we assessed efficiency of the aqueous solution (50–400 ppm) of these oligosaccharides to stimulate the growth in rice seedling. The elicitors which stimulated the seedling growth were later tested in the field for their ability to enhance the growth and yield in rice under six different treatment regimens. In the next two seasons we evaluated the elicitor and treatment regimen, which enhanced the yield and yield contributing factors, at a larger scale. The observations suggest that 200 ppm of alginate oligosaccharide (28.1 kDa) produced by 500 kGy of gamma ray enhances the yield in rice by 13% and improves the seed quality when sprayed during seedling, pre‐flowering and grain‐filling stages. Such treatment improves the overall growth and development of the plant, which probably enhances the yield and grain quality of the produce.
Al‐Decorated C20 Fullerene as a Promising Noble Metal‐Free Catalyst for CO Oxidation: A DFT Study
Authors: Ragab Ahmed H. , Hassan Abeer A. , Khan Adnan Ali 
Published: October 2024

AbstractTo remove the toxic carbon monoxide (CO) gas from the environment, recently, researchers have taken great interest in single‐atom catalysts (SACs). In this study, we investigated various reaction pathways and barrier energies for the CO oxidation process onto Al‐decorated C20 fullerene (Al@C20) employing density functional theory (DFT). The outcomes validate that Al decoration on C20 is energetically stable while the corresponding electronic properties show that the Al atom acts as the reactive site for catalytic activity. The bond distances and larger negative adsorption energies (−0.65 and −2.53 eV) evince that CO and O2 species adsorbed strongly to the Al atom. For the oxidation of CO, two popular mechanisms are examined: Eley Rideal (ER) and Langmuir Hinshelwood (LH). The assessment of energy barriers discloses that the CO oxidation reaction progresses via the LH mechanism. Additionally, the CO + O* →  CO2 reaction proceeds very quickly onto the Al@C20 catalyst, with a very small energy barrier (0.13 eV), indicating the excellent catalytic reactivity of the studied catalyst. These results propose that the designed catalyst can be valuable in the progress of novel noble metal‐free catalysts for harmful CO elimination from the environment.
Mechanistic Insights into Enhanced CO2 Conversion to Fuels and Chemicals with O‐Doped g‐C3N4
Authors: Ranjbakhsh Elnaz , Izadyar Mohammad , Nakhaeipour Ali , Habibi‐Yangjeh Aziz 
Published: October 2024

AbstractIn this work, bare and O‐doped g‐C3N4 nanosheets were synthesized. The results show that the structure of bare and O‐doped g‐C3N4 (OCN) nanosheets are layered and the absorption of visible light increases after O‐doping. Density function theory calculations demonstrate that the oxygen atom is replaced at the edge site of g‐C3N4. The reaction pathway of CO2 reduction to fuel/chemicals on the OCN surface is as follows: CO2→ HCOO→ HCOOH→ HCO + H2O→ H2CO→ H2COH→ H3COH→ CH3 + H2O→ CH4. The main product on the OCN and CN surfaces are methane and methanol, respectively. The Gibbs activation energy of CH3OH formation on the CN and OCN surfaces are 1.72 and 0.14 eV, respectively. The rate‐determining step on the OCN surface is HCOOH→ HCO + H2O, whereas on the CN surface is CH3OH formation from the H3CO intermediate. Therefore, the Gibbs activation energy on the O‐doped g‐C3N4 decreases for the methanol production in comparison with the bare g‐C3N4. In general, the O‐doping of g‐C3N4 improves the photocatalytic activity through the decrement in the band gap and enhances the reaction rate of CO2 conversion to fuels/chemicals.
Tuning the Noise‐Driven Magnetocaloric Effect in Doped GaAs Quantum Dot in View of Tsallis Entropy
Authors: Bhakti Bhaskar , Datta Swarnab , Ghosh Manas 
Published: October 2024

AbstractCurrent inspection strives to perform a detailed elaboration of the Tsallis entropy‐based magnetocaloric effect (MCE) of GaAs quantum dot (QD) doped with Gaussian impurity and under applied Gaussian white noise. Noise takes additive and multiplicative pathways for its entry to the doped QD. MCE has been found to decrease following the enhancement of temperature. The enquiry manifests magnetic field‐induced confinement and consequent decline in the disorder of the system during the gradual variation of several physical parameters. However, harnessing the extent of above confinement involves extremely sensitive and delicate control over the resultant influence of the particular physical parameter undergoing change, its range of magnitude, application of noise and its mode of inclusion. Importantly, MCE has been found to maximize only during the change in the strength of the dopant potential under multiplicative noise. And, on most occasions, multiplicative noise profoundly raises the MCE over its value under the state devoid of noise and under additive noise.
Bio Dyeing of Nylon 6 Fabrics Using Beetroot and Natural Mordants
Authors: Shahmoradi Ghaheh Fatemeh , Haji Aminoddin , Daneshvar Elaheh , Repon Md. Reazuddin 
Published: October 2024

AbstractIn this paper, the potential of beetroot as a natural source to dye a synthetic fiber that is, nylon 6 fabric, has been examined. We analyzed the impact of the most important dyeing parameters, such as dyeing temperature, dyeing time, pH of the dye bath, and dye concentration, on the dyeing efficiency of the nylon 6 fabric. We achieved the optimal conditions for nylon dyeing by beetroot at the boiling temperature for 60 min using 100% on the fabric weight (owf) dye under acidic conditions. Also, to attain suitable color fastness, we used four different natural mordants (pomegranate peel, walnut husk, pistachio hull, and Terminalia Chebula) before the dyeing process. We also examined the effect of four commonly used metal mordants on the dyeing efficiency. FTIR, SEM, EDX and TGA were then conducted to justify the presence of mordants and dyes on the substrate. We discovered that pre‐mordanting generated colorful fabrics based on the type of mordants used. Also, various natural mordants could produce different color strengths, such that the walnut husk had the highest color strength among the used mordants. The obtained color fastness against washing of all bio‐mordants was rated as excellent and the light fastness of Terminalia Chebula was surprisingly excellent. Bio‐mordants also exhibited equivalent washing fastness to metal mordants, even surpassing them in terms of light fastness. The EDX spectra also showed peaks corresponding to carbon (C), nitrogen (N), and oxygen (O). Finally, the fabric mordanted with pomegranate peel exhibited very less mass loss, thus indicating thermal stability.