bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of PIEZO1 Attenuates Kidney Cystogenesis In Vitro and Ex Vivo
Authors: Fan Qingfeng , Hadla Mohamad , Peterson Zack , Nelson Grace , Ye Hong , Wang Xiaofang , Mardirossian Jean Marc , Harris Peter C. , Alper Seth L. , Prakash Y.S. , Beyder Arthur , Torres Vicente E. , Chebib Fouad T. 
Published: October 2024

Key Points

PIEZO1 activation reduces cystogenesis: Yoda1 activates PIEZO1, raising calcium and lowering cAMP, reducing cyst growth in autosomal dominant polycystic kidney disease models.Context-dependent role of PIEZO1: PIEZO1 knockout in mice with or without polycystic kidneys does not affect cyst formation, suggesting redundancy in mechanosensitive pathways.Therapeutic potential: Findings support PIEZO1 activation as a part of combination therapy to slow cyst growth in autosomal dominant polycystic kidney disease, needing more in vivo studies.

Background
The disruption of calcium signaling associated with polycystin deficiency is a key factor in abnormal epithelial growth in autosomal dominant polycystic kidney disease. Calcium homeostasis can be influenced by mechanotransduction. The mechanosensitive cation channel PIEZO1 has been implicated in sensing intrarenal pressure and regulating urinary osmoregulation, but its role in kidney cystogenesis is unclear.

Methods
We hypothesized that altered mechanotransduction contributes to cystogenesis in autosomal dominant polycystic kidney disease and that activation of mechanosensitive cation channels could be a therapeutic strategy.

Results
We demonstrate that Yoda1, a PIEZO1 activator, increases intracellular calcium and reduces forskolin-induced cAMP levels in mouse inner medullary collecting duct (mIMCD3) cells. Notably, knockout of polycystin-2 attenuated the efficacy of Yoda1 in reducing cAMP levels in mIMCD3 cells. Yoda1 also reduced forskolin-induced mIMCD3 cyst surface area in vitro and cystic index in mouse metanephros ex vivo in a dose-dependent manner. However, collecting duct–specific PIEZO1 knockout neither induced cystogenesis in wild-type mice nor altered cystogenesis in the Pkd1RC/RC mouse model.

Conclusions
These findings support the potential role of PIEZO1 agonists in mitigating cystogenesis by increasing intracellular calcium and reducing cAMP levels, but the unaltered in vivo cystic phenotype after PIEZO1 knockout in the collecting duct suggests possible redundancy in mechanotransductive pathways.
Ibrutinib Promotes Atrial Fibrillation by Disrupting A-Kinase Anchoring Protein 1-Mediated Mitochondrial Quality Surveillance in Cardiomyocytes
Authors: Li Yukun , Liu Xinmeng , Lin Rong , Peng Xiaodong , Wang Xuesi , Meng Fanchao , Jin Shuqi , Lv Wenhe , Liu Xiaoying , Du Zhuohang , Wen Songnan , Bai Rong , Ruan Yanfei , Zhou Hao , Zou Rongjun , Tang Ribo , Liu Nian 
Published: October 2024

Background:
Ibrutinib, a potent Bruton’s tyrosine kinase inhibitor with marked efficacy against hematological malignancies, is associated with the heightened risk of atrial fibrillation (AF). Although ibrutinib-induced AF is linked to enhanced oxidative stress, the underlying mechanisms remain unclear.
Objective:
This research aimed to explore the molecular mechanism and regulatory target in ibrutinib-induced AF.
Methods:
We performed in vivo electrophysiology studies using ibrutinib-treated mice, and then employed proteomic and single-cell transcriptomic analyses to identify the underlying targets and mechanisms. The effects of A-kinase anchoring protein 1 (AKAP1) depletion on mitochondrial quality surveillance (MQS) were evaluated using both in vivo and ex vivo AKAP1 overexpression models.
Results:
Atrial AKAP1 expression was significantly reduced in ibrutinib-treated mice, leading to inducible AF, atrial fibrosis, and mitochondrial fragmentation. These pathological changes were effectively mitigated in an overexpression model of ibrutinib-treated mice injected with an adeno-associated virus carrying Akap1. In ibrutinib-treated atrial myocytes, AKAP1 down-regulation promoted dynamin-related protein 1 (DRP1) translocation into mitochondria by facilitating DRP1 dephosphorylation at Ser637, thereby mediating excessive mitochondrial fission. Impaired MQS was also suggested by defective mitochondrial respiration, mitochondrial metabolic reprogramming, and suppressed mitochondrial biogenesis, accompanied by excessive oxidative stress and inflammatory activation. The ibrutinib-mediated MQS disturbance can be markedly improved with the inducible expression of the AKAP1 lentiviral system.
Conclusions:
Our findings emphasize the key role of AKAP1-mediated MQS disruption in ibrutinib-induced AF, which explains the previously observed reactive oxygen species overproduction. Hence, AKAP1 activation can be employed to prevent and treat ibrutinib-induced AF.
Uncovering the reasons behind irregular visits by patients with type 2 diabetes mellitus
Authors: Kuntari Titik , Khotijah Alfreda Amelia , Basya Hana Nuraisa , Cakranegara Rama , Ariant Zinedine Yusuf , Handayani Nina Tiwi 
Published: October 2024

Background: Type 2 diabetes mellitus (DM) is a non-communicable disease with an increasing incidence. DM is associated with deaths caused by several complications. One of the efforts to manage DM is to control blood glucose by maintaining regular check-ups and treatment compliance. Unfortunately, many people with DM still need to visit health facilities regularly.Purpose: This study aimed to explain the factors associated with the irregularity of type 2 DM patients having check-ups at the public health center (puskesmas).Methods: This cross-sectional study used the medical record data from Grabag II Public Health Center. The subjects were 135 outpatients with type 2 DM and complete medical records.Results: The results showed that visit irregularity was significantly associated with sex (OR = 3.8; 95% CI = 1.12-12.79), distance from home (OR = 0.2; 95% CI = 0.06-0.52), and duration of diagnosis (OR = 0.3; 95% CI= 0.12-0.85), but not with age, insurance, comorbidities, and types of therapy.Conclusion: Factors associated with type 2 diabetes mellitus patients' irregular visits to Puskesmas are sex, distance from home, and duration of diagnosis. Educational interventions at all levels of society should be carried out to increase knowledge about DM and the importance of regular check-ups and medication
Current density–voltage characteristics of exciplex-type organic light-emitting diodes expressed by a simple analytic equation
Authors: Yasuda Takeshi , Sakamoto Kenji 
Published: October 2024

Abstract
Exciplex-type bilayer organic light-emitting diodes (OLEDs) with ohmic contacts exhibited current density–voltage (J–V) characteristics that closely matched a simplified analytical model proposed by Nikitenko and Bässler. The analytical model is based on the following key assumptions: (i) complete hole–electron recombination at the interface between a hole transport layer (HTL) and an electron transport layer (ETL), (ii) ohmic contacts at the interfaces between metal electrodes and carrier transport layers, and (iii) electric-field-independent carrier mobilities in both HTL and ETL. The excellent matching shows that the simplified analytical model is sufficient to describe the J–V characteristics of the OLEDs. We also demonstrated that if the carrier mobility of one carrier transport layer is known, that of the other transport layer can be estimated using the equation derived by the simplified analytical model. The simplified analytical model provides a useful method to estimate carrier mobilities within carrier transport layers themselves in OLEDs.
High-resolution mid-infrared image transport by a chalcogenide multi-core fiber
Authors: Nakatani Asuka , Matsumoto Morio , Sakai Goichi , Suzuki Takenobu , Ohishi Yasutake 
Published: October 2024

Abstract
We have successfully demonstrated high-resolution mid-infrared image transport by a multi-core fiber made of chalcogenide glasses. The fiber cores are arranged on a triangular lattice and adjacent cores have different core diameters to reduce cross-talk between them. We tested the resolution of the fiber using different fineness patterns and found that it can resolve better than 25 lp/mmat a wavelength of 9.3 μm. This demonstrates the potential of the fiber for high-resolution thermal imaging inside the human body.
PERAN MAHASISWA MELALUI EDUKASI TERHADAP PELAKSANAAN RESTORATIVE JUSTICE DALAM TINDAK PIDANA PENCURIAN KENDARAAN BERMOTOR (Studi Kasus Di Kejaksaan Negeri Denpasar)
Authors: Carmila Apriliana Mai Sila Patricia , Juwita Arsawati Ni Nyoman 
Published: October 2024

Tidak semua tindak pidana dalam penyelesaiannya di tempuh melalui proses di persidangan, namun, bisa melalui kesepakatan Bersama antar kedua belah pihak yang saling menguntungkan yakni penyelesaian di luar pengadilan atau yang dikenal sebagai alternatif penyelesaian dengan cara restorative justice. Tujuan dari pengabdian masyarakat ini untuk memberikan pemahaman kepada masyarkata tentang pelaksanaan restorative justice dalam tindak pidana pencurian kendaraan bermotor serta mengedukasi kepada masyarakat bahwa adanya restorative justice dapat mewujudkan atau mengedepankan rasa keadilan di masyarakat. Dalam jurnal pengabdian masyarakat ini, penulis menggunakan jenis metode penelitian hukum empiris dengan mengkaji mengenai studi kasus tentang pelaksanaan prinsip restorative justice dalam penyelesaian tindak pidana pencurian berdasarkan observasi melalui magang dan wawancara langsung bersama Jaksa di Kejaksaan Negeri Denpasar. Pelaksanaan restorative justice begitu penting jika dikaitkan dengan Peraturan Kejaksaan Nomor 15 Tahun 2020, karena jika dilihat dari sejarah seiring berjalannya waktu banyak pelaku yang melakukan kejahatan dan lembaga pemasyarakatan (LP) mulai overcapacity sehingga munculah gagasan agar LP tidak lagi overcapacity, dibuatlah pemidanaan yang sifatnya lebih merestorasi dan munculah yang namanya keadilan restoratif atau restorative justice. Hasil dari pengabdian ini menunjukkan bahwa Kejaksaan Negeri Denpasar berkomitmen dalam mengedepankan penegakan hukum yang humanis, melalui pendekatan Restorative yang tidak hanya menyelesaikan kasus tetapi juga menyentuh hati masyarakat serta tercapainya asas peradilan cepat, sederhana, dan biaya ringan berdasarkan hasil studi kasus di wilayah hukum Kejaksaan Negeri Denpasar.

Kata Kunci: Restorative Justice, Tindak Pidana Pencurian, Kejaksaan Negeri Denpasar
Pengaruh Literasi Keuangan dan Inklusi Keuangan Terhadap Kinerja UMKM Rakyat Semarang Kuliner (RANGKUL)
Authors: Arrezqi Misbakhul , Setyadi Dody , Nahar M. , Sugiyanta Sugiyanta , Widyanti Dika Vivi 
Published: October 2024

Usaha Mikro, Kecil, dan Menengah (UMKM) merupakan sektor penting dalam perekonomian Indonesia. UMKM memberikan kontribusi yang signifikan terhadap Produk Domestik Bruto (PDB) dan penyerapan tenaga kerja. Namun, banyak UMKM di Indonesia yang masih mengalami kesulitan untuk berkembang dan bersaing. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh literasi keuangan dan inklusi keuangan terhadap kinerja UMKM rakyat Semarang Kuliner (Rangkul). Penelitian ini menggunakan metode penelitian kuantitatif dengan pendekatan survei. Teknik pengumpulan data pada penelitian ini yakni kuesioner dan literature review. Data yang telah terkumpul kemudian dianalisis menggunakan uji regresi menggunakan bantuan program SPSS. Hasil penelitian menunjukan bahwa literasi keuangan dan inklusi keuangan memiliki pengaruh positif dan signifikan terhadap kinerja UMKM Rangkul. Peningkatan literasi dan inklusi keuangan melalui edukasi dan program-program pemberdayaan dapat membantu UMKM Rangkul dalam meningkatkan kinerjanya dan berkontribusi pada pertumbuhan ekonomi di Semarang.
TOXINA BOTULÍNICA PARA FINS TERAPÊUTICOS
Authors: Dos Santos Jemima Hanã de Oliveira Batista , Adriana Bezerra Cavalcante  , De Oliveira Jeynife Rafaella B. 
Published: October 2024

Introdução: A toxina botulínica é considerada uma neurotoxina produzida pela bactéria Clostridium botulinum, ela é amplamente conhecida por sua aplicação estética, mas seu uso terapêutico tem se expandido significativamente. Objetivo: Analisar a associação da toxina botulínica como fins terapêuticos na odontologia. Metodologia: Trata-se de uma pesquisa bibliográfica exploratória de caráter descritivo realizada por meio das bases de dados PubMed/Medline, Biblioteca Virtual em Saúde e SciELO. A procura por artigos foi realizada fazendo uso dos descritores: “Toxinas Botulínicas Tipo A”, “Qualidade de Vida”, “Usos Terapêuticos”, “Odontologia”, e como critérios de inclusão foram selecionados artigos originais e revisões de literatura em português, inglês e espanhol, entre os anos de 2009 até 2023. Resultados: A toxina botulínica possui a ação baseada na inibição da liberação de acetilcolina na junção neuromuscular, resultando em paralisia temporária dos músculos. Isso a torna útil no tratamento de condições como espasmos musculares, distonias e espasticidade, além de condições menos comuns como enxaquecas crônicas e hiperidrose. A administração é geralmente feita por injeções locais e a eficácia pode variar dependendo da condição tratada e da dose utilizada. Embora a toxina botulínica seja geralmente segura, efeitos colaterais potenciais incluem fraqueza muscular localizada, dor no local da injeção e, em raras ocasiões, reações alérgicas graves. Com isso, o acompanhamento clínico contínuo é essencial para ajustar a dosagem e minimizar riscos. Conclusão: Com isso, conclui-se que o uso terapêutico da toxina botulínica continua a se expandir, conforme novas pesquisas e aplicações surgem, a compreensão e a utilização da toxina botulínica continuam a evoluir, prometendo avanços contínuos em sua eficácia e segurança. Assim, oferecendo benefícios significativos para uma variedade de condições médicas, melhorando a qualidade de vida de muitos pacientes.
ANALISIS PARTISIPASI STAKEHOLDERS DALAM PROYEK REHABILITASI JALAN PADA DINAS PEKERJAAN UMUM DAN PENATAAN RUANG KABUPATEN GARUT (Studi kasus : Proyek Rehabilitasi Jalan di Desa Jati Kecamatan Tarogong Kaler)
Authors: Wahyudi Yudi Triana , Hermawan Yusuf , Rukhiyatul Qudsi Nadhifa 
Published: October 2024

Penelitian ini menganalisis partisipasi stakeholders dalam proyek rehabilitasi jalan pada dinas PUPR kabupaten Garut pada tahun anggaran 2022, dengan fokus penelitian di desa Jati di kecamatan Tarogong Kaler. Menyajikan pentingnya partisipasi dalam berjalannya proyek rehabilitasi jalan. Selanjutnya menguraikan kerangka konseptual, mengeksplorasi konsep partisipasi dalam konteks proyek rehabilitasi jalan pada dinas PUPR kabupaten Garut di tahun anggaran 2022 yang telah dilaksanakan. Metode penelitian yang digunakan, yaitu pendekatan kualitatif dengan analisis deskriptif, dan proses pengumpulan data melalui wawancara mendalam, observasi, dan dokumentasi. Dalam hasil dan pembahasan menyajikan temuan penelitian, termasuk kontribusi semua stakeholder diantaranya yaitu dinas PUPR bagian pemeliharaan jalan, kontraktor, konsultan, desa Jati dan juga masyarakat dalam pelaksanaan proyek rehabilitasi jalan pada tahun 2022 di desa Jati, serta dimensi Voice, dimensi access, dan juga dimensi control yang diberikan dalam pelaksanaan proyek. Terakhir, menyajikan hambatan yang dihadapi selama proses pelaksanaan proyek tersebut. Dalam proyek rhabilitasi yang berjalan ini perlunya dukungan berkelanjutan dari pemerintah daerah dan partisipasi aktif dari seluruh stakeholders agar tecapainya proyek rehabilitasi jalan yang berjalan lancar dan berkualitas, dan memungkinkan suatu kerjasama yang berkelanjutan. Dengan demikian, penelitian ini memberikan kontribusi penting dalam memahami partisipasi stakeholders dalam pelaksanaan proyek rehabilitasi jalan yang ada di dinas PUPR.
Incidencia del Impuesto Predial en los Ingresos Corrientes de Libre Destinación en el Municipio de San Juan del Cesar – La Guajira
Authors: Barro Cabrera Gustavo , Gómez Suárez Tatiana Marcela , Daza Cuello Salvio de Jesús , Oñate Maury Milagros 
Published: October 2024

En esta investigación se analiza la incidencia del impuesto predial como componente de los ingresos corrientes de libre destinación del municipio de San Juan del César, La Guajira, Colombia para los años 2020 – 2021, para tal fin, se utiliza datos suministrados en el municipio. Es así como partir de los mismos se identifican los montos de recaudo por este concepto, y se analiza gráficamente como es el comportamiento del ingreso y del gasto para los años 2020 y 2021 en el municipio, permitiendo así hacer una comparación entre estos periodos. El objetivo general de la investigación es analizar la incidencia del impuesto predial dentro de los ingresos corrientes de libre destinación en el municipio de San Juan del Cesar, La Guajira. Colombia. Las técnicas utilizadas fueron el análisis documental y la entrevista; el instrumento de recolección fue la guía de análisis documental y la guía de entrevista aplicada al Jefe del área de Rentas. Para la validez de los instrumentos se utilizó el juicio de experto, las cuales fueron tres especialistas conocedores del tema (Aguirre Chavez & Zavaleta Bocanegra, 2019). Esta investigación se encuentra en el nivel descriptivo, facilitando las inferencias estadísticas, y tiene un diseño de carácter no experimental, analizando los datos se pudo determinar que el recaudo no tiene un comportamiento uniforme en los años analizados. Además, procede de forma sistemática al estudiarse un fenómeno y conduce a la relación causa efecto de las variables (grado de dependencia) ante una teoría que la soporta como un punto de partida. Además, se evidencia que para el cierre del año 2020 lo recaudado por la administración municipal de San Juan del César por concepto de sobretasa a la gasolina representa el 15% de los ingresos corrientes de libre destinación con un monto de $7.873.492.403 MLV millones de los $1.367.452.568 MLV recaudados en este año, estos ingresos se invirtieron en su mayoría a mejoras administrativas y locativas de la entidad. Finalmente, en relación al objetivo general se destaca la importancia de la incidencia del impuesto predial entre los ingresos corrientes de libre destinación de San Juan del Cesar – La Guajira, Colombia, ya que, esta representa un valor importante entre los ingresos corrientes de libre destinación. Destacando, por su importancia en los años analizados, 2020 y 2021. Los fines que adopta este impuesto son múltiple por la característica de ser de libre destinación.
Bacterias Productoras de Biopeliculas Aisladas de Lesiones Cariosas en Pacientes que Asisten a Consulta Odontológica en un Hospital al Sur de México
Authors: Santiago Dionisio María Cristina , Ramírez Peralta Arturo , Morales Gonzalez Francisco Eulises , Gonzales Herrera Gloria , Rodríguez Bataz Elvia , Adame Gómez Roberto 
Published: October 2024

El proceso carioso inicia con un cambio de microorganismos en la biopelícula supragingival, formándose una biopelícula polimicrobiana en la superficie del diente, siendo de importancia la búsqueda de bacterias con potencial cariogenico capaz de producir biopelícula. El objetivo fue aislar bacterias Gram positivas de lesiones cariosas y determinar la producción de biopeliculas por estos microorganismos. Los pacientes fueron sensibilizados, se firmó un consentimiento informado, el grado de las lesiones cariosas fue determinado de acuerdo con Mount y Hume. La muestra fue tomada por la técnica de aislamiento absoluto. Estas fueron sembradas en agar sangre con CO2 a 37°C durante 24 h. Para la identificación bacteriana fueron utilizadas pruebas bioquímicas y la producción de biopelícula fue determinada por tinción de cristal violeta. La lesión cariosa más prevalente fue de tipo II (35/80), seguido del tipo III (32/80) y por último el tipo I (13/80). El género bacteriano más frecuente fue Streptococcus, siendo la especie bacteriana más frecuente S. mitis en grado de caries I y III, mientras S. oralis en tipo II. Solo las cepas del género Streptococcus fueron capaces de producir biopelícula, donde el 90% y 83.7% de cepas de S. mitis y S. oralis respectivamente fueron productoras de biopeliculas.
Relationship between Sleep Quality and Vertigo Incidence in College Students
Authors: Khairunnisah Sitti Zhaharah , Pratama Ahmad Ardhani , Ratnawati Wahida 
Published: October 2024

One-third of adults are affected by poor sleep quality. Sleep problems are not only experienced by adults. Knowing the relationship between sleep quality and the incidence of vertigo is very important and urgent because of its very broad impact on health, understanding pathophysiology, clinical development, improving quality of life, as well as education and awareness in the community, especially students. In Indonesia, the prevalence of sleep disorders in adolescents is 62.9%. This study aims to determine the relationship between sleep quality and the incidence of vertigo in students. Literature review using Google Scholar, National Center for Biotechnology Information (NCBI) & Research Science found 9 journals based on inclusion & exclusion criteria. The results of the research is the relationship between sleep quality and vertigo involves a complex interaction between physiological and psychological factors. Physiological effects include disorientation and instability, motor coordination, and physiological stress responses such as cortisol. The psychological effects that can occur are anxiety, depression, decreased concentration, decreased cognitive function, and increased psychological discomfort. Lack of sleep in students makes vertigo symptoms worse. Lack of sleep will make vertigo symptoms worse. It is best to arrange the right sleeping position so that symptoms of vertigo do not occur, because vertigo can occur even in people who have never experienced it. The conclusion is there is a relationship between sleep quality and the incidence of vertigo in students.
The Peculiar Radio Evolution of the Tidal Disruption Event ASASSN-19bt
Authors: Christy Collin T. , Alexander Kate D. , Margutti Raffaella , Wieringa Mark , Cendes Yvette , Chornock Ryan , Laskar Tanmoy , Berger Edo , Bietenholz Michael , Coppejans Deanne L. , De Colle Fabio , Eftekhari Tarraneh , Holoien Thomas W.-S. , Matsumoto Tatsuya , Miller-Jones James C. A. , Ramirez-Ruiz Enrico , Saxton Richard , van Velzen Sjoert 
Published: October 2024

Abstract
We present detailed radio observations of the tidal disruption event (TDE) ASASSN-19bt/AT 2019ahk, obtained with the Australia Telescope Compact Array, the Atacama Large Millimeter/submillimeter Array, and the MeerKAT radio telescopes, spanning 40–1464 days after the onset of the optical flare. We find that ASASSN-19bt displays unusual radio evolution compared to other TDEs, as the peak brightness of its radio emission increases rapidly until 457 days post-optical discovery and then plateaus. Using a generalized approach to standard equipartition techniques, we estimate the energy and corresponding physical parameters for two possible emission geometries: a nonrelativistic spherical outflow and a relativistic outflow observed from a range of viewing angles. We find that the nonrelativistic solution implies a continuous energy rise in the outflow from E ∼ 1046 to E ∼ 1049 erg with outflow speed β ≈ 0.05, while the off-axis relativistic jet solution instead suggests E ≈ 1052 erg with Lorentz factor Γ ∼ 10 at late times in the maximally off-axis case. We find that neither model provides a holistic explanation for the origin and evolution of the radio emission, emphasizing the need for more complex models. ASASSN-19bt joins the population of TDEs that display unusual radio emission at late times. Conducting long-term radio observations of these TDEs, especially during the later phases, will be crucial for understanding how these types of radio emission in TDEs are produced.