bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
Authors: Rhee Siyeon , Chung Jae I. , King Devin A. , D’amato Gaetano , Paik David T. , Duan Anna , Chang Andrew , Nagelberg Danielle , Sharma Bikram , Jeong Youngtae , Diehn Maximilian , Wu Joseph C. , Morrison Ashby J. , Red-Horse Kristy 
Published: January 2018

AbstractDuring development, the formation of a mature, well-functioning heart requires transformation of the ventricular wall from a loose trabecular network into a dense compact myocardium at mid-gestation. Failure to compact is associated in humans with congenital diseases such as left ventricular non-compaction (LVNC). The mechanisms regulating myocardial compaction are however still poorly understood. Here, we show that deletion of the Ino80 chromatin remodeler in vascular endothelial cells prevents ventricular compaction in the developing mouse heart. This correlates with defective coronary vascularization, and specific deletion of Ino80 in the two major coronary progenitor tissues—sinus venosus and endocardium—causes intermediate phenotypes. In vitro, endothelial cells promote myocardial expansion independently of blood flow in an Ino80-dependent manner. Ino80 deletion increases the expression of E2F-activated genes and endothelial cell S-phase occupancy. Thus, Ino80 is essential for coronary angiogenesis and allows coronary vessels to support proper compaction of the heart wall.
Biosensing with the singular phase of an ultrathin metal-dielectric nanophotonic cavity
Authors: Sreekanth Kandammathe Valiyaveedu , Sreejith Sivaramapanicker , Han Song , Mishra Amita , Chen Xiaoxuan , Sun Handong , Lim Chwee Teck , Singh Ranjan 
Published: January 2018

AbstractThe concept of point of darkness has received much attention for biosensing based on phase-sensitive detection and perfect absorption of light. The maximum phase change is possible at the point of darkness where the reflection is almost zero. To date, this has been experimentally realized using different material systems through the concept of topological darkness. However, complex nanopatterning techniques are required to realize topological darkness. Here, we report an approach to realize perfect absorption and extreme phase singularity using a simple metal-dielectric multilayer thin-film stack. The multilayer stack works on the principle of an asymmetric Fabry–Perot cavity and shows an abrupt phase change at the reflectionless point due to the presence of a highly absorbing ultrathin film of germanium in the stack. In the proof-of-concept phase-sensitive biosensing experiments, we functionalize the film surface with an ultrathin layer of biotin-thiol to capture streptavidin at a low concentration of 1 pM.
Abnormal grain growth mediated by fractal boundary migration at the nanoscale
Authors: Braun Christian , Dake Jules M. , Krill Carl E. , Birringer Rainer 
Published: January 2018

AbstractModern engineered materials are composed of space-filling grains or domains separated by a network of interfaces or boundaries. Such polycrystalline microstructures have the capacity to coarsen through boundary migration. Grain growth theories account for the topology of grains and the connectivity of the boundary network in terms of the familiar Euclidian dimension and Euler’s polyhedral formula, both of which are based on integer numbers. However, we recently discovered an unusual growth mode in a nanocrystalline Pd-Au alloy, in which grains develop complex, highly convoluted surface morphologies that are best described by a fractional dimension of ∼1.2 (extracted from the perimeters of grain cross sections). This fractal value is characteristic of a variety of domain growth scenarios—including explosive percolation, watersheds of random landscapes, and the migration of domain walls in a random field of pinning centers—which suggests that fractal grain boundary migration could be a manifestation of the same universal behavior.
In silico profiling of systemic effects of drugs to predict unexpected interactions
Authors: Yoo Sunyong , Noh Kyungrin , Shin Moonshik , Park Junseok , Lee Kwang-Hyung , Nam Hojung , Lee Doheon 
Published: January 2018

AbstractIdentifying unexpected drug interactions is an essential step in drug development. Most studies focus on predicting whether a drug pair interacts or is effective on a certain disease without considering the mechanism of action (MoA). Here, we introduce a novel method to infer effects and interactions of drug pairs with MoA based on the profiling of systemic effects of drugs. By investigating propagated drug effects from the molecular and phenotypic networks, we constructed profiles of 5,441 approved and investigational drugs for 3,833 phenotypes. Our analysis indicates that highly connected phenotypes between drug profiles represent the potential effects of drug pairs and the drug pairs with strong potential effects are more likely to interact. When applied to drug interactions with verified effects, both therapeutic and adverse effects have been successfully identified with high specificity and sensitivity. Finally, tracing drug interactions in molecular and phenotypic networks allows us to understand the MoA.
Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope
Authors: Hufnagl Karin , Ghosh Debajyoti , Wagner Stefanie , Fiocchi Alessandro , Dahdah Lamia , Bianchini Rodolfo , Braun Nina , Steinborn Ralf , Hofer Martin , Blaschitz Marion , Roth Georg A. , Hofstetter Gerlinde , Roth-Walter Franziska , Pacios Luis F. , Jensen-Jarolim Erika 
Published: January 2018

AbstractThe major cow’s milk allergen Bos d 5 belongs to the lipocalin protein family, with an intramolecular pocket for hydrophobic ligands. We investigated whether Bos d 5 when loaded with the active vitamin A metabolite retinoic acid (RA), would elicit differential immune responses compared to the unloaded state. Byin silicodocking an affinity energy of −7.8 kcal/mol was calculated for RA into Bos d 5. Loading of RA to Bos d 5 could be achievedin vitro, as demonstrated by ANS displacement assay, but had no effect on serum IgE binding in tolerant or challenge-positive milk allergic children. Bioinformatic analysis revealed that RA binds to the immunodominant T-cell epitope region of Bos d 5. In accordance, Bos d 5 significantly suppressed the CD3+ CD4+ cell numbers, proliferative response and IL-10, IL-13 and IFN-γ secretion from stimulated human PBMCs only when complexed with RA. This phenomenon was neither associated with apoptosis of T-cells nor with the activation of Foxp3+ T-cells, but correlated likely with enhanced stability to lysosomal digestion due to a predicted overlap of Cathepsin S cleavage sites with the RA binding site. Taken together, proper loading of Bos d 5 with RA may suppress its immunogenicity and prevent its allergenicity.
Urban environment predisposes dogs and their owners to allergic symptoms
Authors: Hakanen Emma , Lehtimäki Jenni , Salmela Elina , Tiira Katriina , Anturaniemi Johanna , Hielm-Björkman Anna , Ruokolainen Lasse , Lohi Hannes 
Published: January 2018

AbstractOur companion-animals, dogs, suffer increasingly from non-communicable diseases, analogous to those common in humans, such as allergic manifestations. In humans, living in rural environments is associated with lower risk of allergic diseases. Our aim was to explore whether a similar pattern can be found in dogs, using a nation-wide survey in Finland (n = 5722). We characterised the land-use around dog’s home at the time of birth as well as around its current home, and described several lifestyle factors. The severity of owner-reported allergic symptoms in dogs was estimated with a comprehensive set of questions, developed by experts of canine dermatology. Also, the prevalence of diagnosed allergies in dog owners was recorded. The results indicate that allergic symptoms are more prevalent in urban environments both in dog owners and in dogs (accounting the effect of dog breed). Several factors related to rural living, such as bigger family size and regular contact with farm animals and other pets, were also protective against allergic symptoms in dogs. Interestingly, allergic dogs were more likely to have allergic owners than healthy dogs were. Therefore, we suggest that the mutual presence of allergic symptoms in both species indicates common underlying causal factors of allergic diseases.
Distinct distribution patterns of ammonia-oxidizing archaea and bacteria in sediment and water column of the Yellow River estuary
Authors: Li Mingcong , Wei Guangshan , Shi Wenchong , Sun Zhongtao , Li Han , Wang Xiaoyun , Gao Zheng 
Published: January 2018

AbstractAmmonia oxidation is a critical process of estuarine nitrogen cycling involving ammonia-oxidizing archaea (AOA) and bacteria (AOB). However, the distribution patterns of ammonia-oxidizing microorganisms (AOMs) between different habitats in the same area remain unclear. The present study investigated the AOMs’ abundance and community compositions in both sediment and water habitats of the Yellow River estuary. Quantitative PCR (qPCR) revealed that AOA showed significant higher abundance than AOB both in sediment and water samples. AOA and AOB abundance distribution trends were consistent in sediment but distinct in water along the sampling sites. Clone library-based analyses showed that AOA sequences were affiliated withNitrososphaera, NitrosopumilusandNitrosotaleaclusters. Generally,Nitrososphaerawas predominant in sediment, whileNitrosopumilusandNitrosotaleadominated in water column. AOB sequences were classified into generaNitrosospiraandNitrosomonas, andNitrosospiradominated in both habitats. Principal coordinate analysis (PCoA) also indicated AOA community structures exhibited significant differences between two habitats, while AOB were not. Ammonium and carbon contents were the potential key factors to influence AOMs’ abundance and compositions in sediment, while no measured variables were determined to have major influences on communities in water habitat. These findings increase the understanding of the AOMs’ distribution patterns in estuarine ecosystems.
Refractory Ascites: Treatment and Complications Utilizing Peritoneovenous (Denver) Shunt
Authors: Shadkam-Farrokhi Parvaneh , Lee Edward 
Published: January 2018

AbstractIntractable ascites has long been an antagonizing problem for patients and medical providers. It is debilitating and frequently cannot be prevented by standard medical therapy. Ascites is primarily managed with salt restrictions, diuretics, and repeated paracentesis for symptomatic relief. However, 10% of patients become refractory to this first line of treatment. Several surgical methods such as the insertion of peritoneovenous shunts and transjugular intrahepatic portosystemic shunts have become popularized treatment modalities for the control of refractory ascites. Nevertheless, controversy resides over what is the best treatment method for the improvement in patients' quality of life and survival rate. We herein explore the different medical and surgical methods available for the control of refractory ascites with a focus on the advantages and complications associated with the usage of Denver peritoneovenous shunts.
„Der weisse Andorn ist zur Lungesucht gar gut“
Authors: Niedenthal Tobias , Mayer Johannes 
Published: January 2018

Zusammenfassung
Der Gewöhnliche oder Weiße Andorn (Marrubium vulgare L.) gehörte von der Antike bis weit in die Neuzeit zu den bedeutendsten Heilpflanzen in Europa. Trotz positiver Monografien von Kommission E, ESCOP und HMPC ist der Andorn heute weitgehend aus dem Blickfeld der Phytotherapie verschwunden.
Die Heidelbeere (Vaccinium myrtillus) als Heilpflanze bei Colitis ulcerosa
Authors: Koch Anna , Hapke Jennifer , Langhorst Jost 
Published: January 2018

Zusammenfassung
Die Heidelbeere ist reich an Anthocyanen und zur Behandlung der Colitis ulcerosa trotz mangelnder qualitativ hochwertiger klinischer Studien im Alltag der Patienten längst im Einsatz. Die EMA (European Medicines Agency) spricht für getrocknete Heidelbeeren eine Empfehlung zur Behandlung von Diarrhö auf der Grundlage des traditional use aus und die bisherigen In-vitro-Studien sowie eine klinische Pilotstudie zeigen vielversprechende Ergebnisse. Randomisiert kontrollierte Studien sind jedoch dringend nötig, um die Anwendung auch evidenzbasiert zu rechtfertigen.
Morphological relative frequency impedes the use of stylistic
variants
Authors: Heffernan Kevin , Hiratuka Yusuke 
Published: January 2018

Abstract
The sociolinguistic enterprise has demonstrated that speakers manipulate
linguistic variants as they construct their speech style. Contrary to this
expectation, this study introduces specific cases in which stylistic variation
is highly constrained. We examine the verbal negative suffix in Kansai
vernacular Japanese. We first demonstrate that this variable indexes speech
style. We then show that in a few specific contexts, such as following the verb
stem shir- ‘know’, speakers overwhelmingly use a single
variant, in this case, shira-n ‘not know’. We point out that
the unusual forms such as shira-n all have a high relative
frequency compared to the other forms in their paradigms. Complex forms such as
the English word insane, which occur more frequently than their
parts (in+sane), are difficult to decompose. We claim that this
phenomenon also impedes stylistic variation as forms such as
shira-n are not readily decomposed into verb stem +
negative suffix.
Managing diversity in higher education
Authors: Yusof Norhafezah , Hashim Rosna Awang , Valdez Nena P. , Yaacob Aizan 
Published: January 2018

Abstract
Situated in the first stage of Lewin’s Change Management Model (Lewin, 1947),
this study examined the strategic communication plan needed to enable Higher
Educational Institutions (HEIs) to embrace learner diversity via diversity
engagement. Participants were 56 academics from 14 public and two private
universities in Malaysia who attended the Learner Diversity training module at
the Higher Education Leadership Academy (AKEPT) between the periods from 2014 to
2015. During the training sessions, participants were asked to diagnose the
existing communication strategies of their respective universities that
concerned learner diversity, and to suggest ways to fulfill the mission of
driving diversity in their respective universities. Each participant wrote three
series of reflective writings and these created a total database of 168
reflective notes. The data were analyzed using the six phases of thematic
analysis proposed by Braun and Clarke
(2006). The findings have identified three main themes for a
strategic communication planning approach: (1) re-examining the institutional
mission statement on inclusive diversity practices, (2) changing the mindset of
academe, and (3) starting with small steps when introducing change in embracing
learner diversity. This study served as one of the baseline studies conducted at
the national level to comprehend the potential of a strategic communication
planning process in HEIs from the perspectives of employees.
The vicarious and source credibility grid across cultures
Authors: Dilbeck Keith E. , Domínguez Andrés S. , Ruiz Jon Dornaletetxe , Allen Mike R. 
Published: January 2018

AbstractThe manuscript offers an expansion of a traditional view of source credibility based on evaluation of a message source with inclusion of vicarious credibility (evaluation by members of a social network). The move reflects the need to consider differing cultural perspectives on how a message source might become evaluated. Data from 1,149 participants (US, Spanish, Japanese) identify vicarious and source credibility as significantly different. Classification results from discriminant analysis, where vicarious and source become a single function to create new grounds for cross-cultural communication research. The new paradigm requires the examination of both vicarious credibility in conjunction with source credibility that produce a credibility grid.
Generational differences in workplace communication
Authors: Abdul Malek Marlin Marissa , Jaguli Abd Rahim 
Published: January 2018

AbstractPurpose – This research investigates the generational differences in workplace communication, expectations and behaviors of employees from the perspectives of female leaders and their direct reports.Design – This study employs a qualitative approach through in-depth interviews with 12 female leaders and 24 of their direct reports who are working in various organizations in Malaysia.Findings – Findings include three themes that emerged as key in determining and reflecting the female leaders’ experiences in communicating with their employees in the workplace: (1) attitudes towards power and authority; (2) being creative and taking risks and (3) workplace dynamics.Research Implications – The workplace setting and the leaders’ stance with regards to workplace interaction have seen adjustment towards a flatter and less-hierarchical structure in line with the challenges associated with the 21st century organizations.Practical implications – Leaders and members of the organizations should work towards balancing some traditional and emerging expectations and work practices to better engage with each other.Originality/value – This research highlights the interactions between two distinct groups that are gaining importance and influence in the current workplace; female leaders and the Gen-Ys and uncovers the unique blend between perceived cultural dimensions, the influence of technology advancement and overseas exposure in organizations in Malaysia.
Reframing the figure of the sexual child/teen in Argentine cinema
Authors: Olivera Guillermo 
Published: January 2018

AbstractDrawing on a detailed analysis of a corpus of three key Argentine post-2000 films in which the figure of the child as a sexual/gendered being is central, this article explores three core affective dimensions of the processes of queer child/teenage relational subjectivation. Firstly, it discusses the queer shameful or injured selves of LGBTIQ children/teens as nevertheless being able to open up new spaces of affective performativity that can potentially challenge gender/sexuality norms and boundaries. Secondly, it addresses early queer antagonism associated with the configurative role of the ‘closet space’. Thirdly, emerging processes of peer solidarity and alliances arising from queerness, and non-heteronormative sexualities more generally, are identified and subjected to a political reading in terms of different forms of relationality, mobility and agency. By examining the verbal as well as the visual dimensions of the referential and affective messages inscribed in these films, the analysis attends to both their articulated and non-articulated meanings.
Toward an affective phenomenology of discourse
Authors: Martin Richard Joseph 
Published: January 2018

AbstractTheFifty Shadestrilogy is often associated with BDSM, yet practitioners of BDSM typically disavow the trilogy. Previous research highlights how mechanics of BDSM such as agency and consent are misrepresented in the trilogy; this study highlights differences inaffect. Drawing on ethnographic fieldwork among BDSM practitioners in Berlin, Germany, this paper considers reception beyond reading as evidence of BDSM’s affective phenomenology. The paper combines an Ortner-inspired “cultural ethnography through discourse” with close reading: it compares discourse and affect observed in the field with that in the novels, and suggests that the portrayal of BDSM in the novels and portrayals of the novels as representations of BDSM misinterpret the affective phenomenology of BDSM. Through attention to language, this study shows how affect and situated discourse become mutually constitutive in shaping the legibility of phenomenological experience, suggesting that playful reterritorializations of semiotic forms can counter mimetic perpetuations of symbolic violence.
Narratives of affect
Authors: Lane Nikki 
Published: January 2018

Abstract
Extending the work of those who center narratives in their discussions of affect, this essay considers black queer women’s (BQW) narratives describing the sensations associated with being in and out of spaces created for and by BQW. The narratives examine emerged during ethnographic interviews I conducted in Washington, D.C. between 2012 and 2015. Many BQW living in and around Washington, D.C. socialize within what is colloquially referred to as the Scene – an amorphous, loosely connected set of social networks made up of other BQW and their allies. One of the most important and recognizable aspects of the Scene are the spaces produced for and by these social networks. I refer to these as “scene spaces.” Scene spaces are highly-affect latent sites, as people frequently talk about how space makes them feel, or how they feel in particular spaces. Thus, scene spaces serve as the focal point of this paper’s discussion.
The use of lexical and sublexical cues in speech segmentation by second language learners of English
Authors: Lin Candise Yue , Wang Min 
Published: January 2018

Abstract
This study examined the use of lexical and sublexical cues in speech segmentation by Mandarin L2 learners of English, focusing on
two types of lexical cue, lexical knowledge and semantic relatedness, and three coda (sublexical) cues, /n, s, ŋ/ due to their
varying phonotactic probabilities in Mandarin and English. Thirty-five native English speakers and 30 L2 learners participated in
two experiments. Experiment 1 showed that learners were able to use lexicality as a cue to segment L2 speech. The lexicality
effect significantly interacted with L2 proficiency. Experiment 2 showed that learners did not use semantic cues to the same
extent as native listeners did. All participants experienced more difficulty with word boundary identification preceded by /s/.
This difficulty may stem from weak allophonic cues of /s/ in English. L2 learners with better proficiency may be better at
recognizing familiar words from continuous speech, thus more efficiently utilizing the lexicality cue.
Effects of second language proficiency and working memory span on novel language learning
Authors: Zavaleta Kaitlyn L. , Nicol Janet L. 
Published: January 2018

Abstract
In this paper we examine the effects of prior language learning experience and working memory capacity on learning a novel language. Participants with a range of proficiency in a second language were trained on a third language. They were presented with 20 Turkish words (to test word-learning) and their plural counterparts (to test rule-learning). After training, participants were asked to judge whether a given label correctly matched the pictured object (comprehension) and to verbally produce the correct label for a given object (production). The comprehension test took place immediately after training and again a week later. The production test was administered after the second comprehension test. We found that performance on the initial comprehension test was predicted by working memory span but not L2 proficiency; L2 proficiency predicted learning performance only for the delayed tests. This suggests that the two variables – L2 Proficiency and Working Memory – play different roles in L3 learning.