bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive functional therapy for lower back pain: A meta-analytical assessment of pain and disability outcomes in randomized controlled trials
Authors: Kandeel Mahmoud , Morsy Mohamed A. , Khodair Khalid M. Al , Alhojaily Sameer 
Published: September 2024

BACKGROUND: Cognitive functional therapy (CFT) aims to address low back pain (LBP) comprehensively by considering physical, psychological, and social factors. OBJECTIVE: The objective was to evaluate the effectiveness of CFT in reducing pain and disability in individuals with LBP over various time intervals. METHOD: A comprehensive literature search was conducted to identify relevant randomized controlled trials (RCTs) assessing the effects of CFT on LBP. RESULTS: In this study, 1510 records were initially identified, and 7 studies were included in the analysis. Disability scores were significantly reduced after CFT had been applied for 6 to 8 weeks (SMD =-0.46, 95% CI [-0.74, -0.19]), 12 weeks to 3 months (SMD =-0.54, 95% CI [-0.72, -0.36]), 6 months (MD =-5.82, 95% CI [-9.82, -1.82]), and 12 months (SMD =-0.4, 95% CI [-0.55, -0.26]). There were also significant reductions in pain scores observed after 12 weeks to 3 months (SMD =-0.49, 95% CI [-0.68, -0.3]), 6 months (MD =-0.75, 95% CI [-1.5, -0.0001]), and 12 months (SMD =-0.27, 95% CI [-0.42, -0.12]). CONCLUSION: CFT showed potential for improving disability scores for individuals with LBP across various time intervals. However, its impacts on pain scores varied.
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis
Authors: Alhamawi Renad M. , Aloufi Noof , Alamri Abeer F. , Altubayli Fatima A. , Alsairi Raghad T. , Alhamad Reem A. , Alharbi Shouq M. , Ankhli Zainab A. , Eid Hamza M. A. , Almutawif Yahya A. 
Published: September 2024

BACKGROUND: Invariant natural killer T (iNKT) cells are an immune subset that purportedly link the adaptive and the innate arms of the immune system. Importantly, iNKT cells contribute to anti-cancer immunity in different types of hematological and solid malignancies by secreting pro-inflammatory cytokines. Therefore, using such cells in treating different type of tumors would be an ideal candidate for cancer immunotherapy. OBJECTIVE: To assess the prognostic effect of iNKT cells across different types of solid and hematological tumors. METHODS: In systematic review and meta-analysis, articles assessed the prognostic effect of iNKT cells were systemically searched using the scientific databases including Google Scholar, ScienceDirect, PubMed, Cochrane Central, and Scopus. RESULTS: Strikingly, the analysis showed the positive impact of intratumoral or circulating iNKT cells on the survival rate in patients with all studied tumors with overall effect of a pooled hazard ratio of 0.89 (95% CI 0.81 to 0.98; [Formula: see text] 0.01). A highly statistical heterogeneity was noted between studied tumor with I2 [Formula: see text] 87%; [Formula: see text] 0.00001. CONCLUSIONS: Taken together, this study would present a new insight into the impact of iNKT cells correlate with caner patients’ survival rate and how such cells would be used as a therapeutic target in these patients.
Diagnosis-Related Groups payment reform and hospital cost control
Authors: Lin Ai-Ling , Hou Jian-Hua 
Published: September 2024

BACKGROUND: This study explores the influence of Diagnosis-Related Groups (DRG) payment reform on hospital cost control and offers pertinent cost management strategies for public hospitals. It situates the research by elucidating the significance of the DRG payment method and comparing its advantages and drawbacks with the traditional ‘pay per project’ model. OBJECTIVE: The primary aim is to assess the impact of DRG payment reform on hospital cost control and propose effective cost management strategies for public hospitals. The objective is to provide insights into DRG payment implications and attempt practical recommendations for its implementation in the public healthcare sector. METHODS: Employing a comprehensive approach, the study analyzes DRG payment, delineates advantages and drawbacks, and proposes cost management strategies. Methods include staff training, an information management platform, disease analysis, and optimized cost accounting. The study highlights the potential for improved medical diagnosis and treatment through industry-finance integration. RESULTS: Findings reveal advantages and limitations of DRG payment, emphasizing strategies for optimizing hospital operations. Enhanced medical diagnosis and treatment procedures through industry-finance integration contribute to overall cost control effectiveness. CONCLUSION: The study serves as a practical guide for implementing DRG payment reforms, offering valuable insights for policymakers and healthcare professionals in navigating the complexities of cost control in public healthcare.
A clinical study on 3D virtual model-assisted precise navigation for laparoscopic partial nephrectomy
Authors: Li Han , Li Hui , Tian Yiyang , Hu Xiefeng , Hu Xianhui , Qin Xin , Yin Yong 
Published: September 2024

BACKGROUND: Laparoscopic partial nephrectomy (LPN) is a standard surgical treatment option for renal tumors. Prior to LPN, it is necessary to evaluate the tumor condition and develop a surgical plan using precise imaging. OBJECTIVE: To explore the clinical application value of 3D virtual model (3DVM) in LPN. METHODS: A total of 80 patients with renal tumor who underwent LPN were measured. Patients were divided into three cohorts (A, B, C) according to the difficulty of surgery. Each group was further divided into the test and control groups based on the application of preoperative 3DVM. Surgical safety and efficacy were assessed, and a questionnaire was developed to investigate the opinions of patients and physicians on 3DVM. RESULTS: The duration of LPN and intraoperative renal artery occlusion were significantly different between the test and control groups in both cohorts A and B ([Formula: see text] 0.05). In cohort C, the surgical duration, duration of intraoperative renal artery occlusion, length of stay, time to postoperative ambulation, intraoperative bleeding, incidence of postoperative bleeding were significantly between the two groups ([Formula: see text] 0.05). The analysis both of patients and physicians questionnaire scores were statistically significant ([Formula: see text] 0.05). CONCLUSIONS: 3DVM contributes to safer and more effective LPN. It benefits both doctors and patients.
Lung ultrasound score for prediction of bronchopulmonary dysplasia in newborns: A meta-analysis
Authors: Zhang Xian , Yang Xia , Li Yanhong 
Published: September 2024

BACKGROUND: Bronchopulmonary dysplasia (BPD) ranks among preterm infants’ most common and severe respiratory diseases. Lung ultrasound scores (LUS) play a vital role in predicting early BPD and guiding treatment and intervention strategies for affected patients. OBJECTIVE: Performed a meta-analysis to assess the diagnostic LUS for newborns with BPD. METHODS: Online electronic databases such as MEDLINE, CINAHL, the Cochrane Library, and Web of Science were used to retrieve relevant research until May 2023. A total of 117 literatures were collected, and ten eligible articles were selected for meta-analysis. RESULTS: Meta-analysis was performed on 10 studies (1274 neonates). LUS at 7 days after birth (7 days of life, DOL 7) showed good diagnostic accuracy for any type of BPD, moderate and severe BPD. DOL 7 was more accurate in predicting all types of BPD (AUC [Formula: see text] 0.87, sensitivity [Formula: see text] 0.75, specificity [Formula: see text] 0.83) than moderate and severe BPD (AUC [Formula: see text] 0.80, sensitivity [Formula: see text] 0.69, specificity [Formula: see text] 0.79). There was no statistical significance between DOL 7 and DOL 14 in their accuracy for predicting all types of BPD (difference in AUC [Formula: see text] 0.04, [Formula: see text] 0.068). There was no notable distinction between DOL 7 and DOL 14 in their accuracy for predicting moderate and severe BPD (difference in AUC [Formula: see text] [Formula: see text]0.04, [Formula: see text] 0.104). CONCLUSIONS: The diagnostic efficacy of LUS on DOL 7 in predicting the occurrence of all types of BDP and moderate-severe BPD is determined. This will facilitate rapid and accurate detection and timely treatment, thereby reducing the risk of neonatal mortality and sequelae.
Research progress of music intervention in nursing of premature infants in neonatal intensive care unit
Authors: Xiang Qiong , Chen Jia-Jia , Feng Ni-Na , Li Xian-Hui 
Published: September 2024

BACKGROUND: With the continuous advancement of medical technology, the survival rate of preterm infants is gradually improving, However, due to the underdeveloped function of various organs and systems, preterm infants are often exposed to light, noise, medical as well as nursing operations and other stimuli during their hospitalization in neonatal intensive care unit (NICU); it is highly susceptible to a number of problems, such as pain, unstable vital signs, growth retardation, and sleep disruption. OBJECTIVE: This article reviews the research progress of music intervention in nursing of premature infants in NICU with both traditional and conventional care. METHODS: This article reviews the research background, methodology/design, and measurement/application effects of music interventions, including Chinese and Western traditional music, in the care of preterm infants in NICU. All scholarly literature retrieved from MEDLINE[Formula: see text]PubMed, Science Citation Index Expanded, Google scholar, CNKI scholar, Scopus and PubsHub. RESULTS: As a simple and effective non-pharmacological intervention, music intervention can effectively alleviate neonatal surgical pain, increase heart rate and oxygen saturation, promote sleep, growth and development, and improve neurological development. CONCLUSIONS: This review provide theoretical references for clinical practice.
Meta-analysis of the effects of bundle interventions on ICU-acquired weakness intervention
Authors: Zhou Yan , Liu Yubao , Han Yutong , Yan Hongxia 
Published: September 2024

BACKGROUND: Intensive care unit acquired weakness (ICU-AW) is a secondary neuromuscular complication in critically ill patients, characterized by profound weakness in all four limbs. Studies have shown that bundles of care are nursing strategies that combine a series of evidence-based interventions, which collectively optimize patients’ clinical outcomes compared to individual interventions. OBJECTIVE: This study aims to conduct a meta-analysis of the effects of bundle interventions on ICU-AW deeply exploring the characteristics of bundle interventions, patient outcomes related to ICU-AW, and primarily investigating the effects of bundle interventions on ICU-AW. The main focus is to explore the clinical value of bundle interventions in treatment of ICU-acquired weakness in patients. METHODS: Computer and manual searches were conducted using keywords to retrieve relevant studies on the effects of bundle interventions on ICU-AW from databases such as PubMed, Web of Science, Cochrane Library and EMbase. The search period ranged from database inception to the present. The control group received standard ICU care, including basic nursing, while the intervention group received bundle nursing interventions. RESULTS: A total of 10 randomized controlled trials (RCTs) involving 1545 participants (790 in the intervention group and 755 in the control group) were included. Meta-analysis results showed that the intervention group had significantly higher muscle strength (MD [Formula: see text] 7.41, 95% CI: 6.65–8.16, [Formula: see text] 0.00001) and daily living ability (MD [Formula: see text] 34.01, 95% CI: 32.54–35.48, [Formula: see text] 0.00001) than the control group. Additionally, the incidence of ICU-AW (OR [Formula: see text] 0.39, 95% CI: 0.26–0.59, [Formula: see text] 0.00001), mechanical ventilation time (MD [Formula: see text]3.71, 95% CI: [Formula: see text]3.58[Formula: see text] [Formula: see text]2.76, [Formula: see text] 0.0001), and ICU length of stay (MD [Formula: see text]2.73, 95% CI: [Formula: see text]3.14[Formula: see text] [Formula: see text]2.31, [Formula: see text] 0.00001) were significantly lower in the intervention group than in the control group. CONCLUSION: ICU-AW has a severe negative impact on the recovery and functional restoration of ICU patients, increasing the treatment complexity for healthcare providers and the mortality and disability rates for patients. The bundled care approach may help reduce the incidence of ICU-AW, promote the restoration of daily activity function, enhance muscle strength, and reduce ICU stay and mechanical ventilation time for ICU patients. However, the long-term effects of bundle interventions still require further in-depth research.
Constructing a Set of Kronecker-Pauli Matrices
Authors: Rakotonirina Christian 
Published: September 2024

In quantum physics, the choice of basis is crucial for formulation. The generalization of the Pauli matrices via Kronecker product, called Kronecker-Pauli matrices, is typically restricted to for \(2^n\) dimensional systems. This paper explores extending this generalization to \(N\)-dimensional systems, where \(N\) is a prime integer, in order to construct \(N\times N\)-Kronecker-Pauli matrices. We begin by examining the specific cases of \(3\times 3\) and \(5\times 5\) Kronecker-Pauli matrices, with the goal of the purpose constructing a set of \(N\times N\)-Kronecker-Pauli matrices for any prime integer \(N\).
Perencanaan Kebutuhan Air Bersih pada Gedung Workshop E I dan E II Kampus Teaching Industry Politeknik Negeri Sriwijaya
Authors: Amalia Kiki Rizky , Sari Anggi Nidya , Sakri Harfa 
Published: September 2024

Clean water is a need for every living creature. Clean water is water that physically looks clear and has no smell that is used for daily purposes and can be cooked to make drinking water. In carrying out daily activities, humans need clean water. One of them is in teaching and learning activities at an institution. To ensure comfort in the teaching and learning process, it is necessary to plan the consumption pattern for clean water needs in lecture buildings, one of which is on the Sriwijaya State Polytechnic Teaching Industry campus. Considering the number of academics who will actively carry out activities on this campus, it is necessary to study the planning for clean water usage to obtain water consumption patterns. The research was carried out by taking samples of two buildings, namely buildings E I and E II which were planned as Workshop lecture buildings. Based on calculations and data analysis for planning clean water consumption patterns at the Sriwijaya State Polytechnic Teaching Factory campus, it is 7200 liters/day or 0.083 liters/second for Building E I and 7200 liters/day or 0.083 liters/second for Building E II. The reservoir volume is planned with a capacity of 18 m3 and the tank volume with a capacity of 1 m3.
EVALUASI PENERAPAN ISAK NO 35 TERHADAP PENYUSUNAN LAPORAN KEUANGAN PUSAT PENGEMBANGAN ANAK HERMON TOLOMBUKAN
Authors: Owu Ribka Yuliana Syaloom 
Published: September 2024

Penelitian ini bertujuan untuk mengevaluasi bagaimana Interpretasi Standar Akuntansi Keuangan (ISAK) Nomor 35 diterapkan dalam penyusunan laporan keuangan Pusat Pengembangan Anak Hermon Tolombukan. Tujuan dari interpretasi ini adalah untuk meningkatkan transparansi dan akuntabilitas laporan keuangan entitas yang tidak berorientasi pada laba. ISAK No. 35 merupakan pedoman akuntansi bagi entitas nirlaba, yang meliputi pelaporan aktivitas, neraca, arus kas, dan perubahan aset bersih. Pusat Pengembangan Anak sebagai lembaga nirlaba harus mematuhi standar ini untuk memastikan transparansi, akuntabilitas, serta kelayakan penyajian laporan keuangan kepada pemangku kepentingan Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan studi kasus untuk mengidentifikasi sejauh mana Pusat Pengembangan Anak Hermon Tolombukan telah menerapkan ISAK No. 35 dalam penyusunan laporan keuangannya. Data diperoleh melalui wawancara, dokumentasi, dan observasi langsung terhadap proses penyusunan laporan keuangan. Hasil penelitian menunjukkan bahwa penerapan ISAK Nomor 35 pada PPA yang ada belum sesuai dengan standar akuntansi yang ada. Dengan pelaporan yang sesuai akan memberikan dampak positif terhadap peningkatan akurasi dan transparansi laporan keuangan. Penelitian ini merekomendasikan perlunya pelatihan lebih lanjut bagi pengelola keuangan dan evaluasi berkala untuk memastikan standar akuntansi diterapkan secara konsisten dan efektif. Dengan evaluasi ini, diharapkan dapat meningkatan pembaruan sistem pencatatan keuangan, dan teknis lebih lanjut evaluasi ini diharapkan dapat membantu memastikan penerapan ISAK No. 35 dapat dilaksanakan secara menyeluruh. Serta kualitas dan akuntabilitas laporan keuangan Pusat Pengembangan Anak Hermon Tolombukan di masa mendatang.
Quantitative assessment of the oral microvasculature using optical coherence tomography angiography
Authors: Zhang Tianyu , Zhang Yilong , Liao Jinpeng , Shepherd Simon , Huang Zhihong , Macluskey Michaelina , Li Chunhui 
Published: September 2024

IntroductionEarly diagnosis of oral squamous cell carcinoma can greatly improve treatment success rate and patient survival. Although Optical Coherence Tomography (OCT) based Angiography (OCTA) is a promising in vivo technique in oral imaging, there is a need for objective assessment of oral microvasculature.MethodsThis study aimed to demonstrate a comprehensive methodology of quantitative assessing OCTA intraoral scanning results to provide measurable, reproducible data and to avoid subjective visual interpretations. Data were collected from 37 healthy subjects in total across four intraoral sites—buccal mucosa (n = 32), labial mucosa (n = 24), floor of the mouth (n = 13), and hard palate (n = 8)—using a non-invasive swept-source OCT system. Four quantitative metrics—vessel area density, vessel skeleton density, vessel diameter index, and a newly proposed weighted Tortuosity Index—were used to assess OCTA images in oral applications.ResultsThe quadruple quantitative assessment’s repeatability was evaluated to be reliable. Analysis of a benign ulcer case revealed differences in these metrics compared to healthy cases.Discussion/ConclusionIn conclusion, we demonstrated a comprehensive method to quantify microvasculature in the oral cavity, showing considerable promise for early diagnosis and clinical management of oral diseases.
Decreased ATF5 level contributes to improved mitochondrial function in oocytes exposed to vitrification stress
Authors: Zhou Guizhen , Liu Aiju , Bai Jiachen , Liu Hongyu , Zhu Yixiao , Luo Yuwen , Zheng Lv , Hou Yunpeng , Li Jun , Fu Xiangwei 
Published: September 2024

BackgroundMitochondrial unfolded protein response (mtUPR) plays an essential role in the response of mitochondria to stress-induced damage. Activating of transcription factor 5 (ATF5) can help to sustain mitochondrial function and regulate organelle recovery under mitochondrial stress. Vitrification is a stressor that disrupts mitochondrial activity and cell homeostasis. However, little is known about the function of ATF5 in response to the extreme biophysical and chemical stresses during oocyte vitrification.MethodsThe expression of ATF5 and mtUPR biomarkers were measured in fresh and vitrified oocytes. Subsequently, oocytes with ATF5 deficiency were constructed by siRNA microinjection, and the function of ATF5 in mitochondrial function and oocyte development were analyzed in vitrified oocytes. Furthermore, transcriptome analysis was performed to uncover the molecular network regulated by ATF5 in response to oocyte vitrification.ResultsIn the present study, the mitochondrial membrane potential and ATP levels were decreased in ATF5 knockdown oocytes, in line with the phenotypes observed in vitrified oocytes. In addition, ATF5 knockdown resulted in decreased mitochondrial temperature, reduced unfolded protein levels, abnormal mitochondrial dynamics (fusion and fission), and increased autophagy. Subsequent experiments indicated that mtUPR was suppressed in oocytes with ATF5 knockdown. Interestingly, ATF5 was aberrantly upregulated in oocytes exposed to vitrification stress. Reduced ATF5 expression to a homeostatic level in vitrified oocytes led to accumulated unfolded protein levels and increased mitochondrial membrane potential. Moreover, increased mitochondrial dynamics and an increased germinal vesicle breakdown (GVBD) rate were detected after in vitro maturation. Transcriptome analysis revealed that ATF5 is involved in the vitrification stress response, and ATF5 regulated the in vitro maturation potential in vitrified oocytes through the cAMP-PKA and PI3K/AKT pathways.DiscussionOur findings indicate that mtUPR was initiated in response to vitrification stimuli, and downregulated ATF5 level to a homeostatic state contributes to improved mitochondrial function in oocytes exposed to vitrification stress. Our results highlight the crucial role of ATF5 in the regulation of mitochondrial function in vitrified oocytes through mediating mtUPR.
Artificial intelligence based real-time prediction of imminent heart failure hospitalisation in patients undergoing non-invasive telemedicine
Authors: Hinrichs Nils , Meyer Alexander , Koehler Kerstin , Kaas Thomas , Hiddemann Meike , Spethmann Sebastian , Balzer Felix , Eickhoff Carsten , Falk Volkmar , Hindricks Gerhard , Dagres Nikolaos , Koehler Friedrich 
Published: September 2024

BackgroundRemote patient management may improve prognosis in heart failure. Daily review of transmitted data for early recognition of patients at risk requires substantial resources that represent a major barrier to wide implementation. An automated analysis of incoming data for detection of risk for imminent events would allow focusing on patients requiring prompt medical intervention.MethodsWe analysed data of the Telemedical Interventional Management in Heart Failure II (TIM-HF2) randomized trial that were collected during quarterly in-patient visits and daily transmissions from non-invasive monitoring devices. By application of machine learning, we developed and internally validated a risk score for heart failure hospitalisation within seven days following data transmission as estimate of short-term patient risk for adverse heart failure events. Score performance was assessed by the area under the receiver-operating characteristic (ROCAUC) and compared with a conventional algorithm, a heuristic rule set originally applied in the randomized trial.ResultsThe machine learning model significantly outperformed the conventional algorithm (ROCAUC 0.855 vs. 0.727, p &lt; 0.001). On average, the machine learning risk score increased continuously in the three weeks preceding heart failure hospitalisations, indicating potential for early detection of risk. In a simulated one-year scenario, daily review of only the one third of patients with the highest machine learning risk score would have led to detection of 95% of HF hospitalisations occurring within the following seven days.ConclusionsA machine learning model allowed automated analysis of incoming remote monitoring data and reliable identification of patients at risk of heart failure hospitalisation requiring immediate medical intervention. This approach may significantly reduce the need for manual data review.