bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R
Authors: Do Kee Hun , Park Seong-Hwan , Kim Juil , Yu Mira , Moon Yuseok 
Published: June 2016

AbstractThe polymeric IgR (pIgR) is a central component in the transport of IgA across enterocytes and thereby plays a crucial role in the defense against enteropathogens and in the regulation of circulating IgA levels. The present study was performed to address the novel regulation of pIgR expression in intestinal epithelia undergoing ribosome inactivation. Insults to mucosa that led to ribosome inactivation attenuated pIgR expression in enterocytes. However, IFN regulatory factor-1 (IRF-1) as a central transcription factor of pIgR induction was superinduced by ribosome inactivation in the presence of IFN-γ as a result of mRNA stabilization by the RNA-binding protein HuR. Another important transcription factor for pIgR expression, NF-κB, was marginally involved in suppression of pIgR by ribosome inactivation. In contrast to a positive contribution of HuR in early induction of IRF-1 expression, extended exposure to ribosome inactivation caused nuclear entrapment of HuR, resulting in destabilization of late-phase–induced pIgR mRNA. These HuR-linked differential regulations of pIgR and of IRF-1 led to a reduced mucosal secretion of IgA and, paradoxically, an induction of IRF-1–activated target genes, including colitis-associated IL-7. Therefore, these events can account for ribosome inactivation–related mucosal disorders and provide new insight into interventions for HuR-linked pathogenesis in diverse mucosa-associated diseases, including inflammatory bowel disease and IgA nephritis.
PROPERTIES OF SBR FILLED WITH CARBON BLACK AND ARAMID PULP HYBRID FILLER: COMPARISON BETWEEN PREDISPERSED ARAMID PULP AND CONVENTIONAL ARAMID PULP
Authors: Nillawong Manuchet , Sae-oui Pongdhorn , Suchiva Krisda , Sirisinha Chakrit 
Published: June 2016

ABSTRACT
Compounds of SBR incorporated with hybrid filler of carbon black (CB) and aramid pulp were prepared. The ratio of CB to aramid pulp was varied and its effects on viscoelastic and mechanical properties of the rubber were investigated. Two aramid pulp types were used in this study: conventional aramid pulp (CAP) and the predispersed aramid pulp (PAP). The rubber–filler interaction as indicated by bound rubber content decreases with increasing aramid pulp loading, regardless of the aramid pulp type. This results in a decrease in tensile and abrasion properties with increasing fiber loading. The energy dissipation properties of the hybrid composites are also poorer than those of the CB/SBR composite, as reflected by the heat buildup values. Use of predispersed aramid fiber resulted in improved dispersion of the fiber in SBR. Thus, Mooney viscosities of the PAP-filled systems are lower than those of the CAP-filled systems, but the percentages of elongation at breaks are higher. The distinct feature of aramid fiber/CB hybrid SBR composites is their high moduli over an extended range of temperatures up to 80°C that is unattainable with the use of CB alone.
Performing Lolita: The Japanese Gothic and Lolita Subculture andConstructing Identity through Virtual Space
Authors: Hardy Bernal Kathryn 
Published: June 2016

Abstract
This article investigates the concept of constructing a“Lolita” identity in virtual space. It explores how members ofthe Japanese fashion-based Lolita subculture use the Internet to formulateimages of their desired selves in order to gain acceptance, and establish an“authentic” presence, within worldwide Lolita communities.While members may be geographically separated, they are united in thevirtual world. The affinity gained through online forms of interchange,especially social networking sites, is pertinent for Gothloli who liveoutside Japan, the movement’s place of origin, especially ifreal-life interactions are made less possible by lack of local congregation.However, a downside of Internet visibility, and a consequence of the abilityto hide behind an “anonymous” profile, is the prevalence ofcyberbullying, due to pressures to “fit in,” and thuscompetition and jealousy. This article focuses on these paradoxes and thepositive and negative influences on the Lolita subculture in virtualspace.
Thermal conductivity of vertically aligned boron nitride nanotubes
Authors: Belkerk Boubakeur Essedik , Achour Amine , Zhang Dongyan , Sahli Salah , Djouadi M-Abdou , Yap Yoke Khin 
Published: June 2016

Abstract
For the first time, we report the thermal conductivity of vertically aligned boron nitride nanotube (BNNT) films produced by catalytic chemical vapor deposition. High-quality BNNTs were synthesized at 1200 °C on fused silica substrates precoated with Pt thin-film thermometers. The thermal conductivity of the BNNTs was measured at room temperature by using a pulsed photothermal technique. The apparent thermal conductivity of the BNNT coatings increased from 55 to 170 W m−1 K−1 when the thickness increased from 10 to 28 µm, while the thermal conductivity attained a value as high as 2400 W m−1 K−1. These results suggested that BNNTs, which are highly thermally conductive, but electrically insulating, are promising materials with unique properties.
Effect of hotspot position fluctuation to writing capability in heated-dot magnetic recording
Authors: Tipcharoen Warunee , Warisarn Chanon , Kaewrawang Arkom , Kovintavewat Piya 
Published: June 2016

Abstract
This work presents the effect of hotspot position fluctuation to writing capability in heated-dot magnetic recording systems at an areal density (AD) beyond 2 Tbpsi via a micromagnetic modeling. At high ADs, the hotspot and the write field gradient may not be correctly focused on the target island because the bit islands are closely positioned to one another. This may lead to the overwriting/erasing of the previously written islands, which can severely affect the recording performance. Therefore, this work studies the 3-by-3 data patterns that easily cause an error when the hotspot and write head positions are fluctuated by various island pitches. Simulation results indicate that the data pattern that leads to the highest/lowest error occurrence frequency is the one with the first, second and fourth islands having the opposite/same magnetization direction to/as the write field, regardless of the magnetization direction of the third island. This result can, for example, be utilized to design a two-dimensional modulation code to prevent such destructive data patterns, thus helping enhance the overall system performance.
Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates
Authors: Starr Michelle C. , Harer Matthew W. , Steflik Heidi J. , Gorga Stephen , Ambalavanan Namasivayam , Beck Tara M. , Chaudhry Paulomi M. , Chmielewski Jennifer L. , Defreitas Marissa J. , Fuhrman Dana Y. , Hanna Mina , Joseph Catherine , Kwiatkowski David M. , Krawczeski Catherine D. , Liberio Brianna M. , Menon Shina , Mohamed Tahagod H. , Rumpel Jennifer A. , Sanderson Keia R. , Schuh Meredith P. , Segar Jeffrey L. , Slagle Cara L. , Soranno Danielle E. , Vuong Kim T. , Charlton Jennifer R. , Gist Katja M. , Askenazi David J. , Selewski David T. ,   Neonatal Kidney Health Consensus Workshop, Abitbol Carolyn L. , Ahmad Kaashif A. , Bignall O.N. Ray , Condit Paige E. , Deford Amanda B. , Feeney Alex , Gillen Matthew C. , Guillet Ronnie , Isaac Jaya S. , Jackson Caroline V. , Jetton Jennifer G. , Laster Marciana L. , Lowe Kathryn J. , Marcuccilli Morgan E. , Merrill Kyle A. , Niemyjski Emily A. , Obregon Evelyn , Rademacher Erin R. , Rajadhyaksha Evan A. , Reidy Kimberly J. , Schwartz Samantha R. , Scott Emily K. , Short Kara C. , Stoops Christine N. , Todukar Namrata 
Published: September 2024

ImportanceKidney disease is common in infants admitted to the neonatal intensive care unit (NICU). Despite the risk of chronic kidney disease (CKD) in infants discharged from the NICU, neither evidence- nor expert-based recommendations exist to guide clinical care after discharge.ObjectiveTo develop recommendations for risk stratification and kidney health monitoring among infants after discharge from the NICU.Evidence ReviewAt the National Institute of Health–supported Consensus Workshop to Address Kidney Health in Neonatal Intensive Care Unit Graduates meeting conducted in February 2024, a panel of 51 neonatal nephrology experts focused on 3 at-risk groups: (1) preterm infants, (2) critically ill infants with acute kidney injury (AKI), and (3) infants with critical cardiac disease. Using established modified Delphi processes, workgroups derived consensus recommendations.FindingsIn this modified Delphi consensus statement, the panel developed 10 consensus recommendations, identified gaps in knowledge, and prioritized areas of future research. Principal suggestions include risk stratification at time of hospital discharge, family and clinician education and counseling for subsequent kidney health follow-up, and blood pressure assessment as part of outpatient care.Conclusions and RelevancePreterm infants, critically ill infants with AKI, and infants with critical cardiac disease are at increased risk of CKD. We recommend (1) risk assessment at the time of discharge, (2) clinician and family education, and (3) kidney health assessments based on the degree of risk. Future work should focus on improved risk stratification, identification of early kidney dysfunction, and development of interventions to improve long-term kidney health.
Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches
Authors: Morali Konstantina , Giacomello Gloria , Vuono Michela , Gregori Silvia 
Published: September 2024

Dendritic cells (DC) are professional antigen‐presenting cells involved in promoting and controlling immune responses. Different subsets of DC, named tolerogenic (tol)DC, play a critical role in the maintenance of tissue homeostasis and in fostering tolerance. These unique skills make tolDC especially attractive for strategies aimed at re‐establishing/inducing tolerance in immune‐mediated conditions. The generation of potent tolDC in vitro from peripheral blood monocytes has seen remarkable advancements. TolDC modulate T cell dynamics by favoring regulatory T cells (Tregs) and curbing effector/pathogenic T cells. Among the several methods developed for in vitro tolDC generation, IL‐10 conditioning has been proven to be the most efficient, as IL‐10‐modulated tolDC were demonstrated to promote Tregs with the strongest suppressive activities. Investigating the molecular, metabolic, and functional profiles of tolDC uncovers essential pathways that facilitate their immunoregulatory functions. This Review provides an overview of current knowledge on the role of tolDC in health and disease, focusing on IL‐10 production, functional characterization of in vitro generated tolDC, molecular and metabolic changes occurring in tolDC induced by tolerogenic agents, clinical applications of tolDC‐based therapy, and finally new perspectives in the generation of effective tolDC.
Differences Between True and False Memories Using the Criteria‐Based Content Analysis
Authors: Wachendörfer Merle Madita , Oeberst Aileen 
Published: September 2024

ABSTRACTAlthough not designed for distinguishing true and false memories, several reasons argue for differences in the criteria‐based content analysis (CBCA). As, to the best of our knowledge, previous research did not ensure a comparison between true and false memories, this study sought to do so. Memory reports of 52 participants were rated employing the CBCA by two independent raters. Analyses were based on event reports rated as a memory (where participants believed that the event had occurred and reported additionally remembered details about it) or reports rated as a belief (where participants believed that the event had occurred without remembering details about it). For both samples, the CBCA total score was significantly higher for true than false reports. Exploratory discriminant analyses revealed accuracy rates of 61.3%–69.6% and additional analyses hint towards the cognitive (vs. motivational) criteria as the main drivers of the obtained differences. Further replications are needed.
Rational Modeling and Design of Piezoelectric Biomolecular Thin Films toward Enhanced Energy Harvesting and Sensing
Authors: Dong Liwei , Ke Yun , Liao Yifan , Wang Jingyu , Gao Mingyuan , Yang Yaowen , Li Jun , Yang Fan 
Published: September 2024

AbstractThe dynamic electromechanical coupling behavior of composite materials is highly dependent on external excitation frequency. While degradable biomolecular materials typically exhibit lower piezoelectric coefficients compared to ceramics, neglecting their frequency‐dependent performance in the design of piezoelectric devices further leads to less efficient utilization of their piezoelectric properties. This oversight greatly hinders the practical application of these materials. To address this, a novel fractional derivation (FD) theory‐assisted model is introduced to reversely design the glycine‐polyvinyl alcohol (PVA) thin films for versatile enhanced bio‐applications. An electromechanical coupling model incorporating FD theory is developed to learn the relationships between FD parameters, film dimensions, and dynamic electromechanical properties. This model accurately predicts the electromechanical performance of the films across a wide frequency range, validated by both finite element simulations and experimental results. This therefore allows to establish key design principles for piezoelectric thin film in bioenergy harvesting and sensing, by tailoring thin film parameters to enhance the piezoelectric performance at specific stimuli frequencies. Demonstrations of glycine‐PVA film devices guided by this model reveal excellent performance in ultrasonic energy harvesting and carotid artery bio‐signal sensing. This study provides a robust theoretical framework for designing and optimizing biodegradable piezoelectric materials for various practical applications.
Stabilizing Nickel‐Rich Cathodes in Aqueous Process through Nanocellulose as Water Barrier
Authors: Wang Ying , Fang Ying , Huang Luyao , Wang Jiwei , Zhou Hua , Wang Guanyi , Wu Qingliu , Wang Guofeng , Zhu Hongli 
Published: September 2024

AbstractNickel‐rich LiNi0.8Co0.1Mn0.1O2 (NMC 811) cathode offers high voltage and high specific capacity, making it promising for high energy density batteries. However, large‐scale manufacturing of aqueous‐processed NMC 811 electrodes remains challenging due to proton exchange causing material decomposition and capacity loss. This work addresses this issue by constructing an in situ nanocellulose protective layer for NMC 811 particles via electrostatic interactions during the slurry preparation. For the first time, the interatomic spacing between inter‐chains of nanocellulose is measured through wide‐angle X‐ray scattering and demonstrate the ability to effectively confine interlayer water using atomistic simulations. Moreover, this nanocellulose coverage simultaneously minimizes Li+ surface segregation and mitigates water infiltration. Owing to less material decomposition during the aqueous processing, nanocellulose‐protected NMC electrodes exhibit higher initial coulombic efficiency (83% vs 62% at 0.1C) and capacity (133 vs 59 mAh g−1 at 6C) than unprotected electrodes. Additionally, optimized aqueous‐processed NMC electrodes offer comparable or even superior electrochemical properties compared to the electrodes fabricated using the conventional toxic organic solvent, N‐methyl‐2‐pyrrolidone. Consequently, the developed approach enables affordable, sustainable aqueous processing for Nickel‐rich NMC 811 cathodes with excellent electrochemical performances.
Rapid Forming, Robust Adhesive Fungal‐Sourced Chitosan Hydrogels Loaded with Deferoxamine for Sutureless Short‐Gap Peripheral Nerve Repair
Authors: Dong Qi , Shi Kai , Ai Junjie , Yang Junfeng , Yang Kaidan , Chen Ruina , Wang Yachao , Zhou Yingshan 
Published: September 2024

AbstractClinically, conventional sutures for repair of short‐distance nerve injuries (< 5 mm) may contribute to uncontrolled inflammation and scar formation, thus negatively impacting nerve regeneration. To repair transected peripheral nerves with short distances, a rapid‐forming, robust adhesive chitosan hydrogel is prepared by synthesizing maleic and dopamine bi‐functionalized fungal‐sourced chitosan (DM) and subsequently photopolymerizing DM precursor solution. The hydrogel rapidly polymerized under UV light irradiation (≈2 s) and possessed a strong adhesive strength (273.33 ± 55.07 kPa), facilitating a fast bonding of nerve stump. Especially, its tailored degradation profile over 28 days supported both early gap bridging and subsequent nerve regeneration. Furthermore, deferoxamine (DFO), a pro‐angiogenic drug, is loaded into the hydrogel to reach sustainable release, accelerating axonal growth synergistically. A 3 mm long sciatic nerve defects model in rats is used to investigate the efficacy of DM@DFO hydrogel for repairing peripheral nerve defects. After 60 days, the DM@DFO hydrogel significantly outperformed conventional sutures and fibrin glue, improving motor and sensory recovery by reducing inflammation, inhibiting scar formation, and accelerating vascular regeneration within 14 days post‐repair. This work highlights the DM@DFO hydrogel as a promising tissue adhesive for effective short‐distance peripheral nerve repair.
Squid‐Inspired Anti‐Salt Skin‐Like Elastomers With Superhigh Damage Resistance for Aquatic Soft Robots
Authors: Chu Chengzhen , Sun Wei , Chen Shuo , Jia Yujie , Ni Yufeng , Wang Shaofan , Han Yufei , Zuo Han , Chen Huifang , You Zhengwei , Zhu Meifang 
Published: September 2024

AbstractCephalopod skins evolve multiple functions in response to environmental adaptation, encompassing nonlinear mechanoreponse, damage tolerance property, and resistance to seawater. Despite tremendous progress in skin‐mimicking materials, the integration of these desirable properties into a single material system remains an ongoing challenge. Here, drawing inspiration from the structure of reflectin proteins in cephalopod skins, a long‐term anti‐salt elastomer with skin‐like nonlinear mechanical properties and extraordinary damage resistance properties is presented. Cation‐π interaction is incorporated to induce the geometrically confined nanophases of hydrogen bond domains, resulting in elastomers with exceptional true tensile strength (456.5 ± 68.9 MPa) and unprecedently high fracture energy (103.7 ± 45.7 kJ m−2). Furthermore, the cation‐π interaction effectively protects the hydrogen bond domains from corrosion by high‐concentration saline solution. The utilization of the resultant skin‐like elastomer has been demonstrated by aquatic soft robotics capable of grasping sharp objects. The combined advantages render the present elastomer highly promising for salt enviroment applications, particularly in addressing the challenges posed by sweat, in vivo, and harsh oceanic environments.
Biodegradable Piezoelectric‐Conductive Integrated Hydrogel Scaffold for Repair of Osteochondral Defects
Authors: Liu Dingge , Wang Xinyu , Gao Chenyuan , Zhang Zhihua , Wang Qi , Pei Yin , Wang Haijun , Tang Yujing , Li Ke , Yu Yingjie , Cai Qing , Zhang Xin 
Published: September 2024

AbstractOsteochondral injury is a prevalent condition for which no specific treatment is currently available. This study presents a piezoelectric‐conductive scaffold composed of a piezoelectric cartilage‐decellularized extracellular matrix (dECM) and piezoelectric‐conductive modified gelatin (Gel‐PC). The piezoelectricity of the scaffold is achieved through the modification of diphenylalanine (FF) assembly on the pore surface, while the conductive properties of scaffold are achieved by the incorporating poly(3,4‐ethylenedioxythiophene). In vitro experiments demonstrate that bone marrow mesenchymal stem cells (BMSCs) undergo biphasic division during differentiation. In vivo studies using a Parma pig model of osteochondral defects demonstrate that the piezoelectric‐conductive scaffold exhibits superior reparative efficacy. Notably, the generation of electrical stimulation is linked to joint movement. During joint activity, mechanical forces compress the scaffold, leading to deformation and the subsequent generation of an electric potential difference. The positive charges accumulated on the upper layer of the scaffold attract BMSCs, promoting their migration to the upper layer and chondrogenic differentiation. Meanwhile, the negative charges in the lower layer induce the osteogenic differentiation of BMSCs. Overall, this piezoelectric‐conducive scaffold provides a promising platform for the effective repair of osteochondral defects.
3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review
Authors: Li Suyun , Shan Yanbo , Chen Jingyi , Chen Xiaotong , Shi Zengqin , Zhao Lisheng , He Rujie , Li Ying 
Published: September 2024

AbstractPiezoelectric composites have received widespread attentions in the fields of biomedicine and in vitro wearable devices due to their ability to convert mechanical forces into charge signals. The preparation of piezoelectric composites with complex structures through 3D printing technology can not only effectively improve their piezoelectric output, but also enable their customized therapeutic applications. This paper first introduces the types of piezoelectric composites and reviews the 3D printing technology commonly used in their preparation, analyzing the advantages and disadvantages of each 3D printing technology. Then, the state‐of‐the‐art of the biomedical applications of piezoelectric composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, and in vivo biosensing and in vitro wearable sensing, are emphasized. Finally, the main factors affecting the applications of 3D printed piezoelectric composites are outlooked, and an in‐depth discussion on the challenges toward 3D printed piezoelectric composites are analyzed. This review is believed to provide some fundamental knowledge of 3D printed piezoelectric composites.
Introducing Hydrogen Bond Networks in the Self‐Assembly of Chitin Nanocrystals: Strong and Flexible Bioactive Films Containing Natural Polyphenols
Authors: Massari Daniele , Sgarzi Massimo , Gigli Matteo , Crestini Claudia 
Published: September 2024

AbstractFree‐standing, highly transparent and flexible films are obtained from solvent casting of aqueous colloidal dispersions of surface‐deacetylated chitin nanocrystals. The Young's modulus and the water absorption of the films is further modulated by the addition of three natural polyphenols, i.e., epigallocatechingallate, tannic acid and one lignosulfonate, which differ one another in terms of molecular weight, and overall amount of hydroxy, phenolic and catecholic functionalities. The polyphenolic molecules create an extensive network of hydrogen bonds with the nanocrystals, thus controlling interfacial interactions. Therefore, they act as crosslinkers exerting a reinforcing and structuring action and hampering water absorption. The films do not show dissolution in water upon 7 days of incubation at room temperature, and the release profiles of the polyphenols in aqueous media evidence hindered Fickian diffusion kinetics confirming the presence of interactions with the nanostructured matrix. Lastly, the developed films possess bioactive properties, as they show both radical scavenging and antimicrobial activity. These characteristics are enhanced by the phenolic and, most importantly, catecholic moieties present in tannins (and to a lesser extent in lignins), allowing to reach bactericidal effects as high as 99.99% against both Gram‐positive and Gram‐negative strains.