bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictor Scales of Cognitive Factors Affecting Physical Activity in Individuals Surviving Cancer: Psychometric Properties of Turkish Versions
Authors: Kaya Şura , Esin Melek Nihal 
Published: October 2024

Background:
Increasing physical activity in individuals surviving cancer is crucial in reducing treatment-related side effects and recurrence. Valid and reliable measurement tools are needed that will enable the factors affecting exercise to be addressed holistically and theoretically. This study aimed to adapt the Exercise Goal-Setting Scale, Exercise Planning and Scheduling Scale, Multidimensional Outcome Expectations for Exercise Scale, and Physical Activity Neighborhood Environment Scale into Turkish language and to explore psychometric properties of the Turkish versions of these scales in individuals surviving cancer.

Methods:
This methodologically designed research collected data from 153 participants at a hospital in Istanbul, Türkiye. The scales used in the study were adapted to the Turkish language through forward and backward translation and expert opinion. Content validity was assessed with a 2-week test-retest reliability, Cronbach’s α reliability coefficient for stability, item-total correlation, and confirmatory factor analysis.

Results:
The scales showed good content validity (CVI = 0.95-0.99). Internal consistencies were acceptable to excellent (Cronbach’s α = .79-.94), and moderate to good reproducibility estimates were observed (r = .67-.84). The MOEES factor structure also showed excellent fit.

Conclusions:
This study demonstrates that the adapted scales evaluated are valid and reliable for examining physical activity based on social cognitive processes in individuals surviving cancer in Türkiye. The scales examined in the study can be used to determine the cognitive factors affecting activity and to plan effective programs when providing physical activity counseling to individuals surviving cancer in Türkiye.
The Effects of a Three-Stair Positioning Pillow Used for Preterm Infants on Physiologic Parameters and Sleep-Wakefulness Status
Authors: Bozdag Fatma , Balci Serap 
Published: October 2024

Background:
It is important to provide the necessary sleep for the growth of preterm infants in the neonatal intensive care unit. The purpose of this study was to determine the effect of 3-stair positioning pillows (TSPPs) developed for preterm infants with postnatal age 28 to 35 weeks on physiologic parameters and sleep-wakefulness status.

Methods:
This research was conducted as a randomized controlled experimental study. The CONSORT flowchart was used in the implementation of the randomized controlled trial. The preterm infants in the experimental group were placed in the prone position with TSPPs, whereas the preterm infants in the control group were followed in the routine prone position given in the neonatal intensive care unit. Preterm infants were followed for a total of 3 hours.

Results:
The sample of the study consisted of 60 preterm infants (experiment group = 30; control group = 30) who were hospitalized in the neonatal intensive care unit and met the selection criteria. Compared with the infants in the control group, the preterm infants in the experimental group were determined to have significantly lower heart rates, higher oxygen saturations, lower respiratory rates, longer sleep durations, and shorter wakefulness times (P < .001).

Conclusion:
It was found that positioning preterm infants using TSPP had positive effects on physiological parameters (heart rate, oxygen saturation, and respiratory rate) and sleep-wakefulness status in favor of the experimental group.

Implications for Practice:
It is recommended to use a TSPP that supports the prone position to improve the physiologic parameters and sleep-wakefulness status of preterm infants in the neonatal intensive care unit. Larger studies need to be conducted utilizing longer follow-up protocols. Examining the effectiveness of TSPPs with different positioning materials in preterm infants is needed.
The Effect of Implementation of Skin Care Guidelines on Nurses’ Knowledge Regarding Skin Care and Incidence of Skin Injuries Among Neonates at a Private Tertiary Care Hospital
Authors: Hamid Nazma , Ishtiaq Muhammad , Axelin Anna , Nazir Shahid 
Published: October 2024

Background:
Skin care of sick newborns is important because skin acts as a barrier to prevent neonates from infections which may lead to neonatal morbidity and mortality. The highly technological environment of the neonatal intensive care unit (NICU) makes them vulnerable to loss of skin integrity. In acute care setting maintenance of skin integrity is considered as an established quality indicator representing nursing care.

Aim of Study:
The study aimed to determine the effect of skin care guidelines on nurses’ knowledge related to skincare and the incidence of skin injuries among neonates.

Methodology:
Pre-post quasi-experimental study was conducted in the NICU of a private tertiary care hospital. A consecutive sampling technique was used. The intervention comprised educational sessions and demonstrations of skin care practices from AWHONN skin care guidelines. The data on the nurses’ knowledge were collected through self-developed and self-administered questionnaires. Skin injuries were recorded on a checklist through observation for 1 month before and after the intervention. A paired sample t-test was used for comparing knowledge and continuous demographical variables. While the incidence density ratio was calculated for skin injuries.

Results:
There was a statistically significant improvement in the nurses’ knowledge of skin care from pre (mean 15.06 ± 5.16) to post (mean19.40 ± 5.17) measurement P-value .001. Incidence density rate of skin injuries reduced from 19% to 3% after the implementation of skin care guidelines.

Conclusion:
Through the implementation guidelines nurses’ knowledge and practices regarding skin care improved while skin injuries among neonates were reduced.
Neurological Monitoring and Management for Adult Extracorporeal Membrane Oxygenation Patients: Extracorporeal Life Support Organization Consensus Guidelines
Authors: Cho Sung-Min , Hwang Jaeho , Chiarini Giovanni , Amer Marwa , Antonini Marta Velia , Barrett Nicholas , Belohlavek Jan , Blatt Jason E. , Brodie Daniel , Dalton Heidi J. , Diaz Rodrigo , Elhazmi Alyaa , Tahsili-Fahadan Pouya , Fanning Jonathon , Fraser John , Hoskote Aparna , Jung Jae-Seung , Lotz Christopher , MacLaren Graeme , Peek Giles , Polito Angelo , Pudil Jan , Raman Lakshmi , Ramanathan Kollengode , Dos Reis Miranda Dinis , Rob Daniel , Salazar Rojas Leonardo , Taccone Fabio Silvio , Whitman Glenn , Zaaqoq Akram M. , Lorusso Roberto 
Published: October 2024

Background
Critical care of patients on extracorporeal membrane oxygenation (ECMO) with acute brain injury (ABI) is notable for a lack of high-quality clinical evidence. Here, we offer guidelines for neurological care (neurological monitoring and management) of adults during and after ECMO support.

Methods
These guidelines are based on clinical practice consensus recommendations and scientific statements. We convened an international multidisciplinary consensus panel including 30 clinician-scientists with expertise in ECMO from all chapters of the Extracorporeal Life Support Organization (ELSO). We used a modified Delphi process with three rounds of voting and asked panelists to assess the recommendation levels.

Results
We identified five key clinical areas needing guidance: (1) neurological monitoring, (2) post-cannulation early physiological targets and ABI, (3) neurological therapy including medical and surgical intervention, (4) neurological prognostication, and (5) neurological follow-up and outcomes. The consensus produced 30 statements and recommendations regarding key clinical areas. We identified several knowledge gaps to shape future research efforts.

Conclusions
The impact of ABI on morbidity and mortality in ECMO patients is significant. Particularly, early detection and timely intervention are crucial for improving outcomes. These consensus recommendations and scientific statements serve to guide the neurological monitoring and prevention of ABI, and management strategy of ECMO-associated ABI.
Impact of serum cholinesterase on calcified nodules in patients with stable coronary artery disease
Authors: Kanda Daisuke , Tokushige Akihiro , Ohmure Kenta , Shimono Hirokazu , Tabata Hiroyuki , Ito Nobuhiro , Kubozono Takuro , Ohishi Mitsuru 
Published: October 2024

Background
Calcified nodules (CNs) are an advanced stage of coronary calcification that can have significant clinical implications. We investigated factors associated with CNs, the etiology of which is not fully understood.

Methods
We retrospectively evaluated 619 patients with stable coronary artery disease who underwent intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI). CNs in the culprit lesion were evaluated via IVUS, and all-cause mortality and major cardiovascular and cerebrovascular events (MACCEs) were compared between the CN and non-CN groups.

Results
The CN group (n = 40 patients) had a significantly lower survival rate and a higher incidence of MACCE than the non-CN group (P = 0.020 and P < 0.001, respectively). Multivariate logistic regression analysis models revealed that chronic kidney disease and serum cholinesterase (ChE) level were associated with CN formation [odds ratio (OR): 3.15, 95% confidence interval (CI): 1.30–7.69, P = 0.001 and OR: 0.94, 95% CI: 0.88–0.99, P = 0.042]. The optimal cutoff of serum ChE level as per the receiver operating characteristic curve was 309 units/l (Area under the curve = 0.67, sensitivity = 93%, specificity = 40%, P = 0.001). The low-ChE group divided according to the optimal cutoff value showed significantly higher cumulative incidence of MACCEs after PCI than the high-ChE group as per Kaplan–Meier analysis.

Conclusion
The presence of CNs is significantly associated with a poor prognosis and MACCE after PCI among patients with stable coronary artery disease. Serum ChE levels may affect CN formation.
Utilizing press needle acupuncture to treat mild-to-moderate COVID-19: A single-blind, randomized controlled trial
Authors: Yuan Jiawei , Zhang Weizhen , Qie Beibei , Xie Yuhua , Zhu Binbin , Chen Cheng , Qiu Wenwei , Sun Huanwen , Zhao Bin , Long Yaqiu 
Published: October 2024

Background:
In China, acupuncture has been employed as an adjunctive therapy for coronavirus disease 2019 (COVID-19). Press needle acupuncture is a special type of acupuncture that provides prolonged stimulation to acupuncture points and simultaneously reduces the pain associated with traditional acupuncture. This study assessed the effectiveness of integrating press needles alongside pharmacologic treatment in patients with mild-to-moderate COVID-19.

Methods:
Patients hospitalized with mild-to-moderate COVID-19 symptoms between December 2022 and January 2023 were included in the study. The enrolled patients were randomly assigned to receive pharmacologic treatment alone (control group) or both pharmacologic treatment and press needle acupuncture (intervention group). Patients were evaluated for clinical outcomes, including symptom scores, deterioration rates, fever durations, and nucleic acid test results. The patients’ complete blood count and C-reactive protein levels were also analyzed using venous blood samples both before and after treatment.

Results:
Both groups exhibited a reduction in clinical symptom scores, but symptoms regressed faster in the intervention group. Nucleic acid test negativity was achieved faster in the intervention group than in the control group. The intervention group also had a lower deterioration rate. Furthermore, the increase in the lymphocyte count and decrease in C-reactive protein levels following treatment were more pronounced in the intervention group than in the control group.

Conclusion:
This study suggests that utilizing press needle acupuncture as an adjunct to pharmacologic treatment can be effective in patients with mild-to-moderate COVID-19 symptoms.
Impact of ciprofloxacin with autophagy on renal tubular injury
Authors: Park Woo Yeong , Lim Sun-Ha , Kim Yaerim , Paek Jin Hyuk , Jin Kyubok , Han Seungyeup , Ahn Ki Sung , Lee Jongwon 
Published: October 2024

Backgrounds:
Renal tubular injury caused by oxidative stress and inflammation results in acute kidney injury. Recent research reported that antibiotics may protect renal tubules from progressive deterioration, but the underlying mechanism remains unclear. Therefore, we investigated the efficacy and mechanism of action of antibiotics against renal tubular injury.

Methods:
We screened ciprofloxacin, ceftizoxime, minocycline, and netilmicin and selected ciprofloxacin to examine further because of its low toxicity towards renal tubular cells. We evaluated the effect of ciprofloxacin on cell survival by analyzing apoptosis and autophagy.

Results:
Terminal deoxynucleotidyl transferase-mediated d-UTP nick end labeling (TUNEL) assay results showed that the ciprofloxacin group had less apoptotic cells than the control group. The ratio of cleaved caspase 3 to caspase 3, the final effector in the apoptosis process, was decreased, but the ratio of B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) to Bcl-2 located upstream of caspase 3 was not decreased in the ciprofloxacin group. Therefore, apoptosis inhibition does not occur via Bax/Bcl-2. Conversely, the levels of phosphorylated Bcl-2, and Beclin-1, an autophagy marker, were increased, and that of caspase-3 was decreased in the ciprofloxacin group.

Conclusion:
This indicates that ciprofloxacin enhances autophagy, increasing the amount of free Beclin-1 via phosphorylated Bcl-2, and inhibits caspase activity. Therefore, ciprofloxacin might protect against renal tubular injury through the activation of autophagy in the setting of acute kidney injury.
NBEAL2 gene mutations do not always lead to gray platelet syndrome: A case report
Authors: Chen Bing , Kong Wanzhong , Liu Jinlin , Zhang Junwu 
Published: October 2024

Rationale:
Gray platelet syndrome (GPS) is a rare disease caused by homozygosity and compound heterozygosity for autosomal mutations on the NBEAL2 gene, which is characterized by a deficiency of platelet α-granules, bleeding symptoms. However, in this study, we report 2 NBEAL2 gene mutations in an easy bruising family without gray platelet and bleeding.

Patient concerns:
A 33-year-old female nurse sought admission to our laboratory due to a tendency to bruise easily and unwell in daily life. However, there are no signs of petechiae or excessive bleeding in her daily life. Coagulation tests, routine blood tests and platelet staining of blood smears were all normal.

Interventions:
The whole exome sequencing and Sanger sequencing were used to identify the causative variant of the patient. Furthermore, the morphology of platelets was examined using electron microscopy.

Diagnosis and outcomes:
Whole exome sequencing revealed the presence of 2 mutations in the NBEAL2 gene: p.Thr365fs and p.Ala310Thr. This prompted the consideration of a GPS diagnosis. However, platelet electron microscopy did not identify any abnormalities, leading to the exclusion of GPS.

Lessons:
These 2 NBEAL2 gene mutations (p.Thr365fs and p.Ala310Thr mutations) do not affect the degranulation of platelets.
Ascites production and prognosis after ventriculoperitoneal shunt for diffuse midline gliomas in children: A case series
Authors: Huang Chunxia , Chai Xubin , Han Yunpeng , Lai Keyuan , Ye Yuanyang , Xu Shaoqiang 
Published: October 2024

Rationale:
DMG is a highly invasive and lethal type of brain tumor. As these tumors progress, they often compromise the CSF circulation, leading to hydrocephalus. Ventriculoperitoneal shunt (VPS) is commonly employed to manage hydrocephalus; however, the complication of VPS-induced ascites, particularly in the presence of tumor cells, is a significant concern that merits attention.

Patient concerns:
This case series details 3 pediatric patients diagnosed with brainstem DMG harboring the H3 K27M mutation. Each developed hydrocephalus underwent VPS insertion. Post-operatively, all patients developed carcinomatous ascites with tumor cells detected within the ascitic fluid.

Diagnoses:
All 3 patients were diagnosed with intra-abdominal metastasis of DMG H3K27M mutant cancer cells, each presenting with distinct complications.

Interventions:
Initially, the patients’ primary head tumors responded to treatment, and their hydrocephalus resolved. However, some time after discharge, each patient developed malignant ascites and received palliative chemotherapy to control symptoms and improve quality of life.

Outcomes:
Despite the interventions, all 3 patients died within 1 month of developing malignant ascites, with central respiratory failure being the direct cause of death.

Lessons:
These cases underscore the importance of continuous monitoring of both the CSF and ascitic fluid in patients with gliomas. Regular assessments of biochemical composition, cytology, and other diagnostic tests are crucial for early detection of disease progression. This proactive approach facilitates timely clinical judgment and intervention, potentially improving patient outcomes.
Pulmonary sequestration associated with pulmonary actinomycosis: A case report and literature review
Authors: Wang Yun , Ma Guangfeng , Rao Na-na , Liu Mubo , Liao Jiangrong , Wang Qian-yu 
Published: October 2024

Rationale:
Pulmonary sequestration (PS), a rare pulmonary disease, arises from congenital pulmonary vascular dysplasia. Meanwhile, pulmonary actinomycosis is a purulent infection of lung lesions triggered by the inhalation of actinomycetes, which is also uncommon. Even rarer is the occurrence of pulmonary actinomycete infection secondary to PS. Herein, we present a case report of such a rare occurrence.

Patient concerns:
The 21-year-old female patient had been erroneously diagnosed with pneumonia and tuberculosis, presenting symptoms of cough, sputum, and hemoptysis; however, the implemented anti-infection and antituberculosis treatments proved to be ineffective.

Diagnoses:
The diagnosis of the sequestration in the right lower lung was confirmed through an enhanced chest CT scan and a 3-dimensional reconstruction of the pulmonary vessels.

Interventions:
During the surgical video-assisted thoracoscopic resection of the right lower lobe lesion, it was discovered that the isolated lung tissue’s blood supply vessel originated from the thoracic aorta. Additionally, the pathological examination revealed that the lung tissue of the right lower lobe lesion was infected with pulmonary actinomycetes.

Outcomes:
Following thorough evaluation, the patient received a final diagnosis of pulmonary actinomycete infection that occurred secondary to right lower lung sequestration. Consequently, they underwent treatment consisting of high-dose penicillin administered for a period of 6 months post-operation. Over the course of the subsequent 23-month follow-up, no recurrence of the infection or abnormal CT scan findings were observed.

Lessons:
Pulmonary sequestration bears clinical resemblance to pulmonary actinomycetes. In cases where recurrent episodes of pneumonia occur at the same location, and chest imaging indicates persistent lesions in the basal segment of the lower lobe near the spine, the possibility of PS should be considered. Prompt chest-enhanced CT and 3-dimensional reconstruction of pulmonary vessels are crucial for a definitive diagnosis. Imaging findings such as mass-like consolidation, cystic lesions, liquefactive necrosis, and pneumonia-like changes, coupled with typical air suspension signs and sulfur-like particles visible under tracheoscopy, suggest a potential pulmonary actinomycete infection. Timely biopsy is essential to confirm the diagnosis and prevent missed or incorrect diagnoses.
Chyle leakage after laparoscopic cholecystectomy in a patient with duplicated cystic ducts: A case report and literature review
Authors: Shen Danfeng , Lu Yingchao , Chang Peng , Xu Hongxing 
Published: October 2024

Rationale:
Laparoscopic cholecystectomy (LC) is widely performed as a standard treatment for cholelithiasis, and chyle leakage after LC has rarely been reported. Duplicated cystic ducts draining a single gallbladder is an extraordinarily rare variation.

Patient concerns:
We presented a case of chyle leakage after LC in a 53-year-old female with a rare variation of duplicated cystic ducts.

Diagnoses:
Chyle leakage and duplicated cystic ducts.

Interventions:
Conservative treatment including lipid intake and constant drainage.

Outcomes:
After 24 days of conservative treatment, the patient recovered and had no further troubles during the 3-month follow-up.

Lessons:
There may be a potential relationship between anatomic variants of the extrahepatic bile ducts and those of the lymphatic system. When anatomic variations of the extrahepatic bile ducts are encountered, vigilance for lymphatic system injuries is as important as vigilance for bile duct injuries. Conservative therapy is the first choice for postoperative chyle leakage, and surgical intervention should be considered in cases with high-volume chyle leakage.
Case report and literature review: A young man with giant intra-abdominal Ewing sarcoma
Authors: Yang Guang , Huang Lining , Wu Jianwu , Huang Bo , Zhang Cong , Li Song , Wang Feng , Jiang Xinwei 
Published: October 2024

Rationale:
Extraosseous Ewing sarcoma (EES) is a rare manifestation within the Ewing sarcoma tumor family (ESFT). Its clinical manifestations lack specificity, intestinal obstruction is the main symptom but can also present with abdominal pain, gastrointestinal bleeding, and other discomforts, making it prone to misdiagnosis as intestinal mesenchymal tumor.

Patient concerns:
A 29-year-old male was admitted to the hospital with intestinal obstruction symptoms and abdominal CT suggesting “left abdominal occupation.”

Diagnosis:
The patient was initially misdiagnosed as intestinal mesenchymal tumor, and was later definitively diagnosed as abdominal Ewing sarcoma by postoperative pathology and genetic testing.

Interventions:
Due to the patient’s surgical indication, surgical resection with exploratory laparotomy was performed and then the patient underwent systemic chemotherapy.

Outcomes:
Intraoperatively, we found a 15-cm tumor originating from the proximal jejunum, with invasion into the peritoneum, duodenum, jejunum, and colon. Finally, the pathological report revealed Ewing sarcoma.

Lessons:
Giant abdominal Ewing sarcoma with a diameter of 15 cm is rare. Considering postoperative pathology and genetic testing, abdominal Ewing sarcoma was suspected. The patient was successfully treated using surgery.