bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracting More from Dynamic Modulus Data Using Split-Plot Repeated Measures Analysis
Authors: Buss Ashley , Elkashef Mohamed , Stephenson W. Robert 
Published: December 2017

Abstract
Dynamic modulus testing and the development of master curves is an essential test used to characterize asphalt mixes. The dynamic modulus values are used in the mechanisitic-emprical pavement design guide that is being implemented by many state agencies. To compare dynamic modulus values, most researchers use master curves to analyze the values; however, the log-log scale of the master curve masks the differences between the mixes, requiring the use of an appropriate and reliable statistical data analysis approach to make accurate comparisons between mixes. In this paper, a full experimental plan is designed to investigate the effect of three different factors on the dynamic modulus, namely (1) type of mix: hot mix asphalt versus warm mix asphalt, (2) impact of reheating, and (3) moisture conditioning of specimens. An open-access statistical software package, “R,” is used for the analysis. The data showed that the type of mix and moisture conditioning were statistically significant factors. The statistical analyses presented in this paper begin with a simplified approach and then become increasingly comprehensive. The simplified approach considers a single temperature and frequency only. A more encompassing approach, with the aid of split-plot repeated measures (SPRM) analysis, is then performed in which each of the three factors is considered separately. This is followed by a full analysis on the entire data set that takes into account the interaction between all factors. The benefits of performing a full analysis in lieu of a simplified analysis are highlighted and a detailed interpretation of the results is given.
Transcranial Alternating Current Stimulation Modulates Risky Decision Making in a Frequency-Controlled Experiment
Authors: Yaple Zachary , Martinez-Saito Mario , Awasthi Bhuvanesh , Feurra Matteo , Shestakova Anna , Klucharev Vasily 
Published: December 2017

AbstractIn this study, we investigated the effect of transcranial alternating current stimulation (tACS) on voluntary risky decision making and executive control in humans. Stimulation was delivered online at 5 Hz (θ), 10 Hz (α), 20 Hz (β), and 40 Hz (γ) on the left and right frontal area while participants performed a modified risky decision-making task. This task allowed participants to voluntarily select between risky and certain decisions associated with potential gains or losses, while simultaneously measuring the cognitive control component (voluntary switching) of decision making. The purpose of this experimental design was to test whether voluntary risky decision making and executive control can be modulated with tACS in a frequency-specific manner. Our results revealed a robust effect of a 20-Hz stimulation over the left prefrontal area that significantly increased voluntary risky decision making, which may suggest a possible link between risky decision making and reward processing, underlined by β-oscillatory activity.
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties
Authors: Sharma Vijendra , Ounallah-Saad Hadile , Chakraborty Darpan , Hleihil Mohammad , Sood Rapita , Barrera Iliana , Edry Efrat , Kolatt Chandran Sailendrakumar , Ben Tabou de Leon Shlomo , Kaphzan Hanoch , Rosenblum Kobi 
Published: December 2017

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 α (eIF2α) or other signal transduction cascades. Recently, both eIF2α and its kinases were found to play a role in normal and pathological brain function. Here, we show that reduction of either the amount or the activity of PERK, specifically in the CA1 region of the hippocampus in young adult male mice, enhances neuronal excitability and improves cognitive function. In addition, this manipulation rescues the age-dependent cellular phenotype of reduced excitability and memory decline. Specifically, the reduction of PERK expression in the CA1 region of the hippocampus of middle-aged male mice using a viral vector rejuvenates hippocampal function and improves hippocampal-dependent learning. These results delineate a mechanism for behavior and neuronal aging and position PERK as a promising therapeutic target for age-dependent brain malfunction.SIGNIFICANCE STATEMENTWe found that local reduced protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) expression or activity in the hippocampus enhances neuronal excitability and cognitive function in young normal mice, that old CA1 pyramidal cells have reduced excitability and increased PERK expression that can be rescued by reducing PERK expression in the hippocampus, and that reducing PERK expression in the hippocampus of middle-aged mice enhances hippocampal-dependent learning and memory and restores it to normal performance levels of young mice. These findings uncover an entirely new biological link among PERK, neuronal intrinsic properties, aging, and cognitive function. Moreover, our findings propose a new way to fight mild cognitive impairment and aging-related cognitive deterioration.
An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4
Authors: van Battum Eljo Y. , Verhagen Marieke G. , Vangoor Vamshidhar R. , Fujita Yuki , Derijck Alwin A.H.A. , O'Duibhir Eoghan , Giuliani Giuliano , de Gunst Thijs , Adolfs Youri , Lelieveld Daphne , Egan David , Schaapveld Roel Q.J. , Yamashita Toshihide , Pasterkamp R. Jeroen 
Published: December 2017

During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian CNS is limited in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing CNS regeneration. Here, we performed one of the first miRNome-wide functional miRNA screens to identify miRNAs with robust effects on axon growth. High-content screening identified miR-135a and miR-135b as potent stimulators of axon growth and cortical neuron migrationin vitroandin vivoin male and female mice. Intriguingly, both of these developmental effects of miR-135s relied in part on silencing of Krüppel-like factor 4 (KLF4), a well known intrinsic inhibitor of axon growth and regeneration. These results prompted us to test the effect of miR-135s on axon regeneration after injury. Our results show that intravitreal application of miR-135s facilitates retinal ganglion cell (RGC) axon regeneration after optic nerve injury in adult mice in part by repressing KLF4. In contrast, depletion of miR-135s further reduced RGC axon regeneration. Together, these data identify a novel neuronal role for miR-135s and the miR-135–KLF4 pathway and highlight the potential of miRNAs as tools for enhancing CNS axon regeneration.SIGNIFICANCE STATEMENTAxon regeneration in the adult mammalian CNS is limited in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing regeneration. By performing an miRNome-wide functional screen, our studies identify miR-135s as stimulators of axon growth and neuron migration and show that intravitreal application of these miRNAs facilitates CNS axon regeneration after nerve injury in adult mice. Intriguingly, these developmental and regeneration-promoting effects rely in part on silencing of Krüppel-like factor 4 (KLF4), a well known intrinsic inhibitor of axon regeneration. Our data identify a novel neuronal role for the miR-135–KLF4 pathway and support the idea that miRNAs can be used for enhancing CNS axon regeneration.
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish
Authors: Xia Hui , Zhong Chengrong , Wu Xingxing , Chen Ji , Tao Binbin , Xia Xiaoqin , Shi Mijuan , Zhu Zuoyan , Trudeau Vance L , Hu Wei 
Published: December 2017

Abstract
N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A modification in multiple biological processes, but the in vivo function of m6A has been difficult to study, because mettl3 mutants are embryonic lethal in both mammals and plants. In this study, we have used transcription activator-like effector nucleases and generated viable zygotic mettl3 mutant, Zmettl3m/m, in zebrafish. We find that the oocytes in Zmettl3m/m adult females are stalled in early development and the ratio of full-grown stage (FG) follicles is significantly lower than that of wild type. Human chorionic gonadotropin-induced ovarian germinal vesicle breakdown in vitro and the numbers of eggs ovulated in vivo are both decreased as well, while the defects of oocyte maturation can be rescued by sex hormone in vitro and in vivo. In Zmettl3m/m adult males, we find defects in sperm maturation and sperm motility is significantly reduced. Further study shows that 11-ketotestosterone (11-KT) and 17β-estradiol (E2) levels are significantly decreased in Zmettl3m/m, and defective gamete maturation is accompanied by decreased overall m6A modification levels and disrupted expression of genes critical for sex hormone synthesis and gonadotropin signaling in Zmettl3m/m. Thus, our study provides the first in vivo evidence that loss of Mettl3 leads to failed gamete maturation and significantly reduced fertility in zebrafish. Mettl3 and m6A modifications are essential for optimal reproduction in vertebrates.
El ensayo lírico como experiencia estética-hermenéutica (The Lyric Essay as an Aesthetic-Hermeneutical Experience)
Authors: Hernández Carmona Luis Javier 
Published: December 2017

Se plantea la teorización sobre el ensayo lírico y la generación de la experiencia estética-hermenéutica, a partir de la aplicación de la ontosemiótica como perspectiva metodológica. Con ello, se analizan las prácticas discursivo-literarias que contienen la metarreflexión que desde la extratextualidad da respuesta a los planteos metaforizados, dado que la autonomía del texto y los desdoblamientos del sujeto enunciador implican estrategias de análisis centradas en el cuadrante referencial autor-texto-lector-contexto. Se analizan teorías sobre el ensayo según Montaigne, Lukács, Adorno y Nicol, hasta proponer el ensayo como balance entre lo objetivo y lo subjetivo trascendente. Abstract A theorization is proposed for the lyric essay and the generation of the aesthetic-hermeneutic experience from the application of ontosemiotics as a methodological perspective. A discussion is presented of discursive-literary practices containing meta-reflection which, from extratextuality, responds to metaphorized approaches that for the autonomy of the text and the splits of the enunciating subject require analytical strategies focusing on the referential quadrant author-text-reader-context. Theories on the essay are reviewed, including those of Montaigne, Lukács, Adorno and Nicol, to propose the essay as a balance between the objective and transcendental subjectivity.
Current Complexities of English Teaching in Costa Rica
Authors: Sevilla Morales Henry 
Published: December 2017

AbstractCurrent complexities of English teaching in Costa Rica’s public secondary education are discussed. Using an autoethnographic research approach, critical incidents of an EFL teacher are examined in light of Complexity Theory. Findings suggest that classrooms are unpredictable sites of struggle where multiple rationalities coexist (and often conflict), which must be understood before random decisions are made. For applied linguistics, the study is relevant at three levels: it expands the bulk of literature on the subject, it calls for more attention to the complexities of EFL, and it opens an avenue for reflection and future research directions. ResumenSe analizan ciertos aspectos de las complejidades actuales sobre la enseñanza del inglés de secundaria en la educación pública de Costa Rica. Mediante la autoetnografía, se analizan incidentes críticos de un docente de inglés como lengua extranjera, a la luz de la teoría de la complejidad. Los hallazgos indican que el aula es un espacio de enfrentamientos entre las distintas racionalidades que coexisten, que deben comprenderse ante cualquier toma de decisiones. El estudio atiende tres aspectos: expande la bibliografía sobre el tema, resalta las complejidades de la enseñanza de lenguas extranjeras y abre espacios de reflexión y rutas para investigaciones futuras.
Are Parents Who Feel the Need to Watch Over Their Children’s Care Better Patient Safety Partners?
Authors: Cox Elizabeth D. , Hansen Kristofer , Rajamanickam Victoria P. , Brown Roger L. , Rathouz Paul J. , Carayon Pascale , DuBenske Lori L. , Buel Linda A. , Kelly Michelle M. 
Published: December 2017

OBJECTIVES:Many parents report needing to watch over their child’s hospital care to prevent mistakes. In this study, we assessed whether needing to watch over care predicts parent performance of recommended safety behaviors to reduce medication errors and health care–associated infections.METHODS:At admission, we surveyed 170 parents about their need to watch over care, demographics, and hospitalization factors. At discharge, parents were surveyed about medication awareness and hand hygiene behaviors. Logistic regression was used to examine how parents’ need to watch over care predicted each behavior, adjusting for demographics and hospitalization factors.RESULTS:Thirty-eight percent of parents reported needing to watch over care. Most parents (77%) reported frequently or very frequently asking providers for drug names or doses. Fewer parents asked to check drug or infusion accuracy (29%) or to show or read aloud medication labels (21%). Few parents reminded providers to clean hands (4%), but most stated they would be comfortable asking (82%) and likely to speak up if a provider did not (78%). After adjustment, parents needing to watch over care were significantly more likely to ask providers to check drug or infusion accuracy (adjusted odds ratio = 4.59, 95% confidence interval 2.14–9.94) and for drug name or dose (adjusted odds ratio = 3.04, 95% confidence interval 1.25–7.39).CONCLUSIONS:Parents who report the need to watch over care are more likely to perform behaviors specific to safe medication use (but not hand hygiene) compared with those not reporting this need. Opportunities exist to engage parents as safety partners by leveraging their need to watch over care toward system-level safety initiatives.
Watcher Initiative Associated With Decrease in Failure to Rescue Events in Pediatric Population
Authors: McClain Smith Melanie , Chumpia Maryanne , Wargo Lindsey , Nicol Julie , Bugnitz Mark 
Published: December 2017

BACKGROUND AND OBJECTIVES:
Improved situation awareness may prevent unplanned ICU transfers. Transfers with serious safety issues may be classified as unrecognized situation awareness failure events (UNSAFE) and are associated with intubation, vasopressors, or &gt;3 fluid boluses within 1 hour before or after ICU arrival. Our aim was to decrease the proportion of unplanned ICU transfers that met UNSAFE criteria by 50% in 1 year.

METHODS:
We adapted a previously described huddle-based intervention. In May 2015, we started a daily safety brief with hospital-wide representation; concurrently, nurses and residents separately identified watcher patients (ie, patients at risk for UNSAFE transfers) to be reported in the daily safety brief. Watcher patients frequently differed between the groups, so in July 2015, we started twice-daily watcher huddles on a pilot floor. During these huddles, nurses and residents jointly identified watcher patients on the basis of defined criteria and deployed mitigation plans. By March 2016, we implemented these huddles hospital-wide. We reviewed the electronic medical record to categorize all unplanned ICU transfers as safe or UNSAFE. Our outcome was the proportion of unplanned ICU transfers that met UNSAFE criteria.

RESULTS:
In the 16-month pre-intervention period, 49 of the 322 unplanned ICU transfers were UNSAFE (median 15.5%); in the 12-month post-intervention period, 13 of the 329 unplanned ICU transfers were UNSAFE (median 3%). These findings represent an 81% reduction in the proportion of UNSAFE transfers.

CONCLUSIONS:
Watcher huddles incorporated into the daily inpatient routine can significantly decrease UNSAFE transfers.
Trends in Executive Functioning in Extremely Preterm Children Across 3 Birth Eras
Authors: Burnett Alice C. , Anderson Peter J. , Lee Katherine J. , Roberts Gehan , Doyle Lex W. , Cheong Jeanie L.Y. ,   for the Victorian Infant Collaborative Study Group
Published: December 2017

BACKGROUND AND OBJECTIVES:
To determine if executive functioning outcomes at school age are different for extremely preterm (EP; &lt;28 weeks’ gestation) or extremely low birth weight (ELBW; &lt;1000 g birth weight) children born in 1991 to 1992, 1997, and 2005 relative to their term-born peers.

METHODS:
Population-based cohorts of all EP/ELBW survivors born in the state of Victoria, Australia, in 1991 to 1992, 1997, and 2005, and contemporaneous controls (matched for expected date of birth, sex, mother’s country of birth [English speaking or not], and health insurance status) were recruited at birth. At 7 to 8 years of age, parents of 613 children who were EP/ELBW and 564 children who were controls rated their children’s executive functioning on the Behavior Rating Inventory of Executive Function (BRIEF). The proportion of children with elevated BRIEF scores (in the clinically significant range) in each birth group and era was compared by using logistic regression. Sensitivity analyses explored these associations after excluding children with intellectual impairment.

RESULTS:
Across the eras, EP/ELBW children had higher rates of elevated scores than controls in almost all BRIEF domains. The 2005 EP/ELBW cohort had increased executive dysfunction compared with earlier cohorts, particularly in working memory and planning and organization. This effect persisted after accounting for demographic factors and weakened slightly when those with intellectual impairment were excluded.

CONCLUSIONS:
These results indicate a concerning trend of increasing executive dysfunction for EP/ELBW children who were born more recently. This may have adverse implications for other functional domains, such as academic achievement and social-emotional well-being.
Competência em informação e desinformação: critérios de avaliação do conteúdo das fontes de informação | Information literacy and disinformation: criteria for evaluating the content of information sources
Authors: Zattar Marianna 
Published: December 2017

RESUMO Apresenta as principais estratégias para avaliação dos conteúdos das fontes de informação. Utiliza as noções de competência em informação (American Library Association e Dudziak), fontes de informação (Cunha e Tomáel) e desinformação (Fallis e Volkoff) para o desenvolvimento do referencial teórico. Indica a metodologia exploratória a partir de uma revisão de literatura orientada para que o problema apresentado seja mais explícito no campo de estudos da informação. Apresenta como resultados a indicação de três critérios para avaliação de fontes de informação para que sejam evitados os compartilhamentos e usos de desinformações (e seus respectivos impactos negativos) na prática informacional. Por fim, evidencia que a necessidade de avaliação é essencial para a solidariedade na produção e para o uso crítico e ético da informação.Palavras-chave: Competência em Informação; Fontes de Informação; Desinformação.ABSTRACT The paper presents the main strategies to evaluate the contents of information sources. It uses the notions of information literacy (American Library Information and Dudziak), information sources (Cunha and Tomaél) and disinformation (Fallis and Volkoff) to develop the theoretical framework. It indicates the exploratory methodology based on a literature review in order to explicit the problem presented in the field of information studies. It presents, as results, the indication of three criteria for the evaluation of information sources to avoid sharing and using disinformation (and their negative impacts) in the information practice. Finally, it shows that the need for evaluation is essential to solidarity in the production and to the critical and ethical use of information.Keywords: Information Literacy; Information Sources; Disinformation.
“Uma legião de imbecis”: hiperinformação, alienação e o fetichismo da tecnologia libertária | “A legion of imbeciles”: hyperinformation, alienation, and the fetishism of libertarian technology
Authors: Moretzsohn Sylvia Debossan 
Published: December 2017

RESUMO Este artigo procura avançar na tentativa de demonstrar como a afirmação de que a inter-net inauguraria uma nova era para a humanidade é a mais recente expressão do feti-chismo da tecnologia. Aponta a mistificação da propalada “horizontalidade”, que enco-bre as relações de poder e escancara as portas para a disseminação das “fake news”, ins-taurando um ambiente de absoluta insegurança informativa. Sustenta que hiperinforma-ção, que leva ao aprofundamento da alienação pelo excesso de oferta, é essencial para a manutenção do sistema. Conclui que a tendência de formação de “bolhas” favorece a constituição de comunidades seguras de si e infensas ao contraditório, o que é o avesso de qualquer perspectiva democrática.Palavras-chave: Hiperinformação; Alienação; Fetichismo; Tecnologia; Redes Sociais.ABSTRACT This article seeks to demonstrate how the statement that the internet would inaugurate a new era for humanity is the latest expression of technological fetishism. It points to the mystification of the so-called “horizontality” which hides power relations and opens the door to the dissemination of “fake news”, creating an environment of absolute informational insecurity. It argues that hyperinformation, which leads to the deepening of alienation by oversupply, is essential for the maintenance of the system. It concludes that the tendency to form “bubbles” favours the constitution of communities that are self-assured and closed to conterarguments, which is the opposite of any democratic perspective.Keywords: Hyperinformation; Alienation; Fetishism; Technology; Social Network.
Underground taming of floods for irrigation (UTFI) in the river basins of South Asia: institutionalising approaches and policies for sustainable water management and livelihood enhancement
Authors: Reddy V. Ratna , Pavelic Paul , Hanjra Munir A. 
Published: December 2017

Abstract
Underground taming of floods for irrigation (UTFI) is a new approach for mitigating flood impacts through targeted floodwater storage in depleted aquifers for irrigating crops in the dry season. UTFI not only fosters the much-desired conjunctive use and management of water resources but also provides the environmental services that are of high socioeconomic value. UTFI interventions are individually established at the local scale (e.g. village pond, check dam) but to achieve more substantial positive benefits at the scale of meso watersheds (10 s of km2) or sub-basins (100–1,000 s of km2) in the flood-prone river basins requires area-based implementation. Given the nature and scale required, UTFI needs to be managed at the community level with the help of appropriate institutional arrangements taking into account both the upstream and downstream locations. This paper reviews the existing institutional approaches and proposes an institutional framework that can help to mainstream UTFI management in the context of South Asia. The proposed model is centred on the existing formal institutions and also integrates non-market (participatory) and market (payments for environmental services) instruments that can provide win–win strategies for water resource management to downstream and upstream communities.