bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term right ventricular changes in mustard‐exposed patients: A historical cohort
Authors: Khosravi Arezoo , Motamedi Mohamad Ali , Kazemi‐Saleh Davoud , Aslani Jafar , Ghanei Mostafa 
Published: October 2017

AbstractIntroductionMustard gas (MG) is a chemical warfare agent widely used in the Iran‐Iraq War. Its catastrophic effects on the lungs, eyes, and skin have been well studied. However, it also affects the cardiovascular system. We aimed to evaluate the long‐term effect of MG on right ventricular (RV) function.MethodsAll patients presenting to the university clinics between May 2014 and September 2015 were consecutively evaluated to enter the study based on the inclusion criteria (documented proof of chemical injury, no past or present cardiovascular disease, not a current smoker, and no history of sleep apnea). A comparable control group of veterans without MG exposure was randomly selected. All patients underwent echocardiographic measurement of RV size and function by a blinded cardiologist.ResultsWe included 23 patients in the MG‐exposed group and 19 subjects in the control group, with a mean age of 48.6 years. Mean chemical injury severity score was 29.7% and mean time from the MG exposure was 29.2 years. The main complaint of MG‐exposed patients pertained to respiratory symptoms (91%). Pulmonary artery pressure was higher (32.83 vs. 28.95 mmHg) and RV strain was lower (−17.05% vs. −20.72%) in the MG‐exposed than in the control group (P < .05).ConclusionOur results present baseline RV values for MG‐exposed patients and show mild but significant changes after 3 decades. Further cellular and molecular studies are needed to evaluate underlying mechanisms of MG cardiotoxicity.
Racial Discrimination and Health Outcomes Among Racial/Ethnic Minorities: A Meta‐Analytic Review
Authors: Carter Robert T. , Lau Michael Y. , Johnson Veronica , Kirkinis Katherine 
Published: October 2017

In this meta‐analysis, the authors reviewed 105 studies on the relationships between racial discrimination and health outcomes among racial/ethnic minority Americans. The authors tested for moderator effects of measurement strategies, cultural factors, substance use, gender, and racial group differences. Findings indicate a statistically significant effect size between racial discrimination and health, with the largest effect for mental health and strongest for studies with multi‐item measures.En este metaanálisis, los autores revisaron 105 estudios sobre las relaciones entre la discriminación racial y los resultados para la salud entre americanos pertenecientes a minorías raciales o étnicas. Los autores examinaron los efectos moderadores de las estrategias de medición, los factores culturales, el uso de sustancias, el género y las diferencias entre grupos raciales. Los hallazgos indican un efecto de tamaño estadísticamente significativo entre la discriminación racial y la salud, con el máximo efecto observado en la salud mental y el más fuerte en estudios con mediciones múltiples.
Impact of Social Support and Coping on Acculturation and Acculturative Stress of East Asian International Students
Authors: Ra Young‐An , Trusty Jerry 
Published: October 2017

The purpose of this study was to investigate the effects of social support and coping on acculturation and acculturative stress of international students. The authors used hierarchical multiple regression analysis to study a sample of 232 East Asian international students. The results indicate that social support and coping were partial mediators on the relationship between acculturation and acculturative stress. Implications, limitations, and recommendations for future research are provided.El propósito de este estudio fue investigar los efectos del apoyo social y el afrontamiento en la aculturación y el estrés aculturativo de los estudiantes internacionales. Se estudió una muestra de 232 estudiantes internacionales de Asia Oriental usando un anaálisis de regresión múltiple jerárquica. Los resultados indican que el apoyo social y el afrontamiento fueron mediadores parciales en la relación entre aculturación y estrés aculturativo. Se proporcionan implicaciones, limitaciones y recomendaciones para investigaciones futuras.
Race, Ethnicity, and Gender of Faculty Members in APA‐ and CACREP‐Accredited Programs: Changes Over Five Decades
Authors: Baggerly Jennifer , Tan Tony Xing , Pichotta David , Warner Aisha 
Published: October 2017

This study examined changes in race, ethnicity, and gender of faculty members in APA‐ and CACREP‐accredited counseling programs over 5 decades based on the year of their degree. Of those faculty members working in accredited programs who graduated in the 1960s/1970s, 26.7% were female, 5.6% were racially diverse, and 1.7% were Latina/o. Of those who graduated 5 decades later, 63% were female, 18% were racially diverse, and 4.9% were Latina/o. Implications are discussed.Este estudio examinó los cambios en raza, etnicidad y sexo de los miembros del profesorado en programas de consejería acreditados por la APA y CACREP a lo largo de 5 décadas basados en el año de graduación del profesor. De aquellos miembros del profesorado trabajando en programas acreditados que se graduaron en las décadas de los 60 y 70, el 26.7% fueron mujeres, el 5.6% racialmente diversos y el 1.7% latinos. De aquellos que se graduaron 5 décadas después, el 63% fueron mujeres, el 18% racialmente diversos y el 4.9% latinos. Se discuten las implicaciones.
In vivo assessment of the placental anatomy and perfusion in a mouse model of intrauterine inflammation
Authors: Wu Dan , Lei Jun , Jia Bei , Xie Han , Zhu Yan , Xu Jiadi , Mori Susumu , Zhang Jiangyang , Burd Irina 
Published: October 2017

BackgroundMagnetic resonance imaging (MRI) provides useful markers to examine placental function. MRI features of placental injury due to intrauterine inflammation—a common risk during pregnancy, are not well known.PurposeTo investigate the capability of structural MRI and intravoxel incoherent motion (IVIM) imaging in examining acute placental injury in a mouse model of intrauterine inflammation, as well as gestation‐dependent placental changes.Study TypeProspective study.Animal ModelPregnant CD1 mice were scanned on embryonic day 15 (E15, n = 40 placentas from six dams) and E17. On E17, mice were subjected to intrauterine injury by exposure to lipopolysaccharide (LPS, n = 25 placentas from three dams) or sham injury (n = 25 placentas from three dams).Field Strength/SequenceIn vivo MRI was performed on an 11.7T Bruker scanner, using a fast spin‐echo sequence and a diffusion‐weighted echo‐planar imaging (EPI) sequence.AssessmentT2‐weighted MRI was acquired to evaluate placental volume. IVIM imaging was performed in a restricted field‐of‐view using 15 b‐values from 10–800 s/mm2, based on which, the pseudodiffusion fraction (f), pseudodiffusion coefficient (D*), and tissue water coefficient (D) were estimated with a two‐step fitting procedure.Statistical TestsTwo‐way analysis of variance (ANOVA) was used to evaluate the group differences.ResultsThe placental volume increased by ∼21% from E15 to E17 (P < 0.01), and a 15% volume loss was observed at 6 hours after LPS exposure (P < 0.01). IVIM parameters (f, D*, and f·D*) were similar between the E15 and E17 sham groups (P > 0.05), which was significantly reduced in the LPS‐exposed placentas compared to the shams (P < 0.001). D values decreased from E15 to E17 (P < 0.05), which were further reduced after LPS exposure (P < 0.05). Changes in placental area and vascular density were histologically identified in the LPS‐exposed group, along with gestation‐dependent changes.Data ConclusionOur results suggested structural MRI and IVIM measurements are potential markers for detecting acute placental injury after intrauterine inflammation.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:1260–1267.
Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading: Roles of calcium sources and cell membrane ion channels
Authors: Lv Mengxi , Zhou Yilu , Chen Xingyu , Han Lin , Wang Liyun , Lu X. Lucas 
Published: October 2017

ABSTRACTMechanical loading on articular cartilage can induce many physical and chemical stimuli on chondrocytes residing in the extracellular matrix (ECM). Intracellular calcium ([Ca2+]i) signaling is among the earliest responses of chondrocytes to physical stimuli, but the [Ca2+]i signaling of in situ chondrocytes in loaded cartilage is not fully understood due to the technical challenges in [Ca2+]i imaging of chondrocytes in a deforming ECM. This study developed a novel bi‐directional microscopy loading device that enables the record of transient [Ca2+]i responses of in situ chondrocytes in loaded cartilage. It was found that compressive loading significantly promoted [Ca2+]i signaling in chondrocytes with faster [Ca2+]i oscillations in comparison to the non‐loaded cartilage. Seven [Ca2+]i signaling pathways were further investigated by treating the cartilage with antagonists prior to and/or during the loading. Removal of extracellular Ca2+ ions completely abolished the [Ca2+]i responses of in situ chondrocytes, suggesting the indispensable role of extracellular Ca2+ sources in initiating the [Ca2+]i signaling in chondrocytes. Depletion of intracellular Ca2+ stores, inhibition of PLC‐IP3 pathway, and block of purinergic receptors on plasma membrane led to significant reduction in the responsive rate of cells. Three types of ion channels that are regulated by different physical signals, TRPV4 (osmotic and mechanical stress), T‐type VGCCs (electrical potential), and mechanical sensitive ion channels (mechanical loading) all demonstrated critical roles in controlling the [Ca2+]i responses of in situ chondrocyte in the loaded cartilage. This study provided new knowledge about the [Ca2+]i signaling and mechanobiology of chondrocytes in its natural residing environment. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:730–738, 2018.
Inducing drought tolerance in wheat by applying natural and synthetic plant growth promoters
Authors: Shaukat Muhammad , Ahmad Ashfaq , Rasul Fahd , Khaliq Tasneem , Mudassir Muhammad Akhlaq , Yasin Mubashra 
Published: October 2017

AbstractCrop productivity in future may be limited due to water scarcity. However, foliar spray of plant growth promoters may boost crop production even in adverse environments. In the present study, foliar application of one natural (moringa leaf extract, 3% MLE) and four synthetic (Polydol, Multisol, Classic, and Asahi Star) were applied at tillering, jointing, booting, and heading growth stages of wheat (Triticum aestivum L.) during severe, moderate, and light drought and well‐watered condition. No spray and water spray were taken as controls. Results showed significant reduction in growth parameters such as total dry matter production, mean crop growth rate, net assimilation rate, leaf area index, and duration due to drought employed at various phenophases of wheat. However, improvement in these parameters was observed after foliar application of growth promoters, whereas interactive effects between factors were found non‐significant. The activities of catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD) were more accelerated under drought treatments from exogenously supplied growth promoters. Foliar application of promoters significantly alleviated drought‐induced reduction of yield and related traits. Grain weight (15%) and grain yield (27%) were improved due to exogenously applied MLE under moderate drought stress treatments relative to controls. Furthermore, 16% higher grain yield and 17% saving of irrigation water over fully irrigated and without promoter treatment (farmers' practice) was recorded from foliar‐applied MLE under skipped irrigation at jointing. In conclusion, foliar‐applied MLE may ameliorate drought‐induced deleterious effects by enhancing antioxidant activities under drought stress.
Pincushion of Tubule Discovery and Tubular Morphology Landscape Establishment of Block Copolymer Self‐Assemblies
Authors: Sun Xiao‐Li , Liu Dong‐Ming , Li Shun‐Shun , Li Kang‐Kang , Wan Wen‐Ming 
Published: October 2017

AbstractBlock copolymer (BCP) self‐assembly is a versatile technique in the preparation of polymeric aggregates with varieties of morphologies. However, its morphology library is limited. Here, the discovery of pincushion of tubules is reported for the first time, via BCP self‐assembly of poly(4‐vinylpyridine)‐b‐polystyrene (P4VP‐b‐PS) with very high molecular weight (500 kDa) and asymmetry (2 mol% P4VP). The investigation confirms the importance of core‐forming block length on morphology control of BCP self‐assemblies, especially with respect to tubular structures. The morphology landscape of tubular structures is successfully established, where dumbbell of tubule, tubule, loose clew of tubules, tight clew of tubules, and pincushion of tubules can be prepared by adjusting the core‐forming block length. This work therefore expands the structure library of BCP self‐assemblies and opens up a new avenue for the further applications of these tubular materials.
Cognitive changes in prodromal Parkinson's disease: A review
Authors: Fengler Sophie , Liepelt‐Scarfone Inga , Brockmann Kathrin , Schäffer Eva , Berg Daniela , Kalbe Elke 
Published: October 2017

AbstractAlthough other nonmotor phenomena representing possible prodromal symptoms of Parkinson's disease have been described in some detail, the occurrence and characteristics of cognitive decline in this early phase of the disease are less well understood. The aim of this review is to summarize the current state of research on cognitive changes in prodromal PD. Only a small number of longitudinal studies have been conducted that examined cognitive function in individuals with a subsequent PD diagnosis. However, when we consider data from at‐risk groups, the evidence suggests that cognitive decline may occur in a substantial number of individuals who have the potential for developing PD. In terms of specific cognitive domains, executive function in particular and, less frequently, memory scores are reduced. Prospective longitudinal studies are thus needed to clarify whether cognitive, and specifically executive, decline might be added to the prodromal nonmotor symptom complex that may precede motor manifestations of PD by years and may help to update the risk scores used for early identification of PD. © 2017 International Parkinson and Movement Disorder Society
Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice
Authors: Lee Da‐Hye , Kim Min Jung , Ahn Jiyun , Lee Sang Hee , Lee Hyunjung , Kim Jin Hee , Park So‐Hyun , Jang Young‐Jin , Ha Tae‐Youl , Jung Chang Hwa 
Published: October 2017

ScopeCheonggukjang (CGJ) is a soybean‐based quick‐fermented food popular in Korea that contains a variety of biologically active compounds including isoflavones and saponins. Isoflavone bioavailability may be important for the bone health of postmenopausal women; therefore, the aim of this study is to evaluate the influence of fermentation on the isoflavone metabolite nutrikinetic profile after single dose CGJ or unfermented soybean administration in ovariectomized (OVX) and sham mice.Methods and resultsWe identify 34 isoflavone metabolites using UPLC–QTOF‐MS and analyze their nutrikinetics at different time points (0.25, 0.5, 1, 2, 4, 8, 16, and 24 h) to understand their fermentation‐ and OVX‐mediated time‐dependent concentration changes. Nutrikinetics analysis shows that genistein, daidzein, genistein 4′‐sulfate, dihydrodaidzein sulfate, equol 4′‐sulfate, and equol‐7‐glucuronide are present at high concentrations in all groups based on area‐under‐the‐curve analysis. OVX mice appear to show lower isoflavone bioavailability than mice in the sham group. CGJ enhances various isoflavone metabolite bioavailability including genistein, 3‐hydroxygenistein, and equol 7‐glucuronide, compared to the unfermented soybean‐treated group. Among these metabolites, intact isoflavones, 3‐hydroxygenistein, genistein 4′‐sulfate, and equol 7‐glucuronide promote osteoblastogenesis and inhibit osteoclast formation.ConclusionsCGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women.
Charcot–Marie–Tooth Disease type 4C: Novel mutations, clinical presentations, and diagnostic challenges
Authors: Jerath Nivedita U. , Mankodi Ami , Crawford Thomas O. , Grunseich Christopher , Baloui Hasna , Nnamdi‐Emeratom Chioma , Schindler Alice B. , Heiman‐Patterson Terry , Chrast Roman , Shy Michael E. 
Published: October 2017

ABSTRACTIntroductionThis study analyzes and describes atypical presentations of Charcot–Marie–Tooth disease type 4C (CMT4C).MethodsWe present clinical and physiologic features of 5 patients with CMT4C caused by biallelic private mutations of SH3TC2.ResultsAll patients manifested scoliosis, and nerve conduction study indicated results in the demyelinating range. All patients exhibited signs of motor impairment within the first years of life. We describe 2 or more different genetic diseases in the same patient, atypical presentations of CMT, and 3 new mutations in CMT4C patients.DiscussionA new era of unbiased genetic testing has led to this small case series of individuals with CMT4C and highlights the recognition of different genetic diseases in CMT4C patients for accurate diagnosis, genetic risk identification, and therapeutic intervention. The phenotype of CMT4C, in addition, appears to be enriched by a number of features unusual for the broad CMT category. Muscle Nerve 57: 749–755, 2018
Effect of very old age on anconeus motor unit loss and compensatory remodelling
Authors: Gilmore Kevin J. , Kirk Eric A. , Doherty Timothy J. , Rice Charles L. 
Published: October 2017

ABSTRACTIntroduction: It is not known how the process of compensatory remodeling through collateral reinnervation continues into very old age (>80 years) or whether there is a limit to effective motor unit (MU) reinnervation. Therefore, we explore electrophysiological properties related to motor unit number estimates (MUNEs) in very old participants (79–90 years of age) compared with young controls (25–29 years of age). Methods: Decomposition‐enhanced spike‐triggered averaging was used to collect surface and intramuscular electromyography information from the anconeus to derive a MUNE. Results: Young participants had a MUNE of ∼38 and ∼25 at 30% and 50% root mean squared maximum voluntary contraction (RMSMVC) with surface motor unit potentials (S‐MUPs) of ∼145 μV and 236 μV, respectively. Older participants had a MUNE of ∼23 and ∼16 at 30% and 50% RMSMVC with S‐MUPs of 168 μV and 232 μV, respectively. Discussion: In this muscle, an age limit to successful remodeling through collateral reinnervation, to compensate for the presumed ongoing losses of MUs, may have been surpassed. Muscle Nerve 57: 659–663, 2018
The effect of group integrative reminiscence therapy on mental health among older women living in Iranian nursing homes
Authors: Musavi Motahareh , Mohammadian Sara , Mohammadinezhad Bahar 
Published: October 2017

AbstractAimThe present study aimed to determine the impact of group integrative reminiscence therapy on mental health of older women living in Iranian nursing home in 2016.DesignA quasi‐experimental design pre‐ and post‐test was used in the present study. Purposive sampling was used to recruit participants who met the study criteria.MethodThe statistical population included 60 older women living in nursing home, among whom 46 having the inclusion criteria were selected as the sample. After completing the Goldberg's General Health Questionnaire, the older people were divided into intervention (N = 23) and control (N = 23) group by using block randomization method. The intervention groups were trained by integrative reminiscence therapy for 60–90 min 10 sessions, twice a week. Descriptive statistics and ANOVA were used for data analysis by SPSS software.ResultsThe results indicated that group integrative reminiscence therapy significantly affected general mental health and physical dimensions, anxiety and insomnia, social functions and depression.
Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors
Authors: Rahman Mohammad A. , Midde Narasimha M. , Wu Xiaoxin , Li Wei , Kumar Santosh 
Published: October 2017

AbstractDiallyl sulfide (DAS), a selective inhibitor of CYP2E1, has shown protective effects against alcohol‐ and acetaminophen‐induced hepatotoxicity in many studies. However, DAS is also a CYP2E1 substrate that on metabolism produces toxic metabolites and causes cytotoxicity. The objective of this study was to find a potent DAS analog as a CYP2E1 inhibitor and has the characteristic of producing less toxic metabolites. We selected seven commercially available compounds that are similar to DAS (DAS analogs). First, we performed ligand‐CYP2E1 docking study to determine the binding mode and binding energy. The analysis suggested a relative potential for these DAS analogs as CYP2E1 inhibitor. We then performed a comprehensive inhibition kinetics of DAS analogs and determined the relative IC50, Ki, and types of inhibition compared to that of DAS. The results showed that compared to DAS, diallyl ether and allyl methyl sulfide have lower Ki values (3.1 and 4.4 μmol/L, respectively, vs. 6.3 μmol/L for DAS) and IC50 values (6.3 and 11.4 μmol/L, respectively, vs. 17.3 μmol/L for DAS). However, allyl methyl sulfide and thiophene showed similar inhibitory capacities to that of DAS, and four other DAS analogs showed lower potency than DAS. In conclusion, we have found relatively more potent inhibitors of CYP2E1, which have lower toxicity than DAS. These compounds can replace DAS not only as a tool for in vitro and in vivo studies that involve CYP2E1 inhibition, but also can lead the way for their use in preventing CYP2E1‐mediated hepatic toxicity of alcohol and acetaminophen.
Multicolor, Fluorescent Supercapacitor Fiber
Authors: Liao Meng , Sun Hao , Zhang Jing , Wu Jingxia , Xie Songlin , Fu Xuemei , Sun Xuemei , Wang Bingjie , Peng Huisheng 
Published: October 2017

AbstractFiber‐shaped supercapacitors have attracted broad attentions from both academic and industrial communities due to the demonstrated potentials as next‐generation power modules. However, it is important while remains challenging to develop dark‐environment identifiable supercapacitor fibers for enhancement on operation convenience and security in nighttime applications. Herein, a novel family of colorful fluorescent supercapacitor fibers has been produced from aligned multi‐walled carbon nanotube sheets. Fluorescent dye particles are introduced and stably anchored on the surfaces of aligned multi‐walled carbon nanotubes to prepare hybrid fiber electrodes with a broad range of colors from red to purple. The fluorescent component in the dye introduces fluorescent indication capability to the fiber, which is particularly promising for flexible and wearable devices applied in dark environment. In addition, the colorful fluorescent supercapacitor fibers also maintain high electrochemical performance under cyclic bending and charge‐discharge processes.