bluuebunny/crossref_metadata_2025_split huggingface dataset:
The molecular basis of immunosuppression by soluble CD52 is defined by interactions of N-linked and O-linked glycans with HMGB1 Box B
Authors: DeBono Nicholas J. , D’Andrea Silvia , Bandala-Sanchez Esther , Goddard-Borger Ethan , Zenaidee Muhammad A. , Moh Edward S.X. , Fadda Elisa , Harrison Leonard C. , Packer Nicolle H. 
Published: October 2024

AbstractHuman soluble CD52 is a short glycopeptide comprising 12 amino acids (GQNDTSQTSSPS) which functions as an immune regulator by sequestering the pro-inflammatory high mobility group box protein 1 (HMGB1) and supressing immune responses. Recombinant CD52 has been shown to act as a broad anti-inflammatory agent, dampening both adaptive and innate immune responses. This short glycopeptide is heavily glycosylated, with a complex sialylated N-linked glycan at N3 and reported O- linked glycosylation possible on several serine and threonine residues. Previously we demonstrated that specific glycosylation features of CD52 are essential for its immunosuppressive function, with terminal α-2,3-linked sialic acids required for binding to the inhibitory SIGLEC-10 receptor leading to T-cell suppression. Using high resolution mass spectrometry, we have further characterised the N- and O-linked glycosylation of Expi293 recombinantly produced CD52 at a glycopeptide and released glycan level, accurately determining glycan heterogeneity of both N- and O-linked glycosylation, and localising the site of O-glycosylation to T8 with high confidence and direct spectral evidence. This detailed knowledge of CD52 glycosylation informed the construction of a model system, which we analysed by molecular dynamics simulations to understand the mechanism of recognition and define interactions between bioactive CD52, HMGB1 and the SIGLEC-10 receptor. Our results confirm the essential role of glycosylation, more specifically hyper-sialylation, in the function of CD52, and identify at the atomistic level specific interactions between CD52 glycans and the Box B domain of HMGB1 that determine recognition, and the stability of the CD52/HMGB1 complex. These insights will inform the development of synthetic CD52 as an immunotherapeutic agent.
Do the shuffle: Expanding the synthetic biology toolkit for shufflon-like recombination systems
Authors: Katalinić Jan , Richards Morgan , Auyang Alex , Millett James H. , Kogenaru Manjunatha , Windbichler Nikolai 
Published: October 2024

AbstractNaturally occurring DNA inversion systems play an important role in the generation of genetic variation and adaptation in prokaryotes. Shufflon invertase (SI)Rcifrom plasmid R64, recognizing asymmetricsfxsites, has been adopted as a tool for synthetic biology. However, the availability of a single enzyme with moderate rates of recombination has hampered the more widespread use of SIs. We identified 14 previously untested SI genes and theirsfxsites in public databases. We established an assay based on single-molecule sequencing that allows the quantification of the inversion rates of these enzymes and determined cross-recognition to identify orthogonal SI/sfxpairs. We describe SI enzymes with substantially improved shuffling rates when expressed in an inducible manner inE. coli. Our findings will facilitate the use of SIs in engineering biology where synthetic shufflons enable the generation of millions of sequence variantsin vivofor applications such as barcoding or experimental selection.
Nexus between audit committee characteristics and audit report lag in an emerging economy: an analysis using frequentist and Bayesian regression models
Authors: Sobhan Raihan , Mim Fahmida Fayaja , Rahman Fariha 
Published: October 2024

PurposeThe objective of this study is to investigate the association between audit committee characteristics and audit report lag in the context of listed manufacturing companies in Bangladesh.Design/methodology/approachData from 240 firm-year observations for 2018–2022 are collected and analyzed using both the pooled-ordinary least squares (OLS) model with panel corrected standard errors (PCSE) and the Bayesian regression model. The results are explained in line with the agency theory and resource dependence theory.FindingsThe study reveals that audit committee size, gender diversity and expertise are negatively and significantly associated with audit report lag. The results remain consistent using the lag model, which indicates that the current year’s audit committee can have an impact on the subsequent year’s audit report lag.Research limitations/implicationsThe study has been conducted in the context of Bangladesh and thus cannot be generalized for other countries.Practical implicationsThe study implies that companies should form large audit committees and ensure higher participation of female members and expert members in forming such committees. Policymakers and regulators can also play roles in this regard to ensure the timely issue of audit reports.Originality/valueThis is one of the pioneer studies to investigate the link between audit committee characteristics and audit report lag in the context of an emerging economy like Bangladesh. This study advocates agency theory by linking audit committee characteristics to reduced information asymmetry and contributes to resource dependence theory by emphasizing their role in enhancing financial reporting timeliness.
Value co-creation in sustainable express delivery: intergenerational perspectives
Authors: Gao Fei , Qi Wene 
Published: October 2024

PurposeThe express delivery industry faces challenges engaging consumers in sustainable practices. This study explores how sustainable service quality affects corporate loyalty, mediated by value co-creation (VCC) and green customer satisfaction. It also scrutinizes low-carbon knowledge as a moderator and investigates variances in VCC outcomes between Generation Y and Generation Z consumer groups.Design/methodology/approachAn empirical study involves a scenario experiment and a questionnaire answered by 596 Chinese consumers in 2023. Partial least squares structural equation modeling (PLS-SEM) tests proposed relationships. Regression analysis examines the chain mediating effect of VCC and green satisfaction, while group analysis assesses intergenerational differences.FindingsSustainable service quality positively influences consumer VCC, which in turn impacts customers’ green satisfaction and corporate loyalty. VCC and green satisfaction act as intermediaries between sustainable service quality and corporate loyalty. Low-carbon knowledge positively moderates sustainable service quality's impact on VCC. Generation Y and Generation Z show differences in the relationship between VCC and loyalty.Practical implicationsExpress delivery firms should enhance sustainable service quality and encourage consumer participation in VCC activities. This can improve consumer green satisfaction, loyalty and competitive advantages.Originality/valueThis study expands service marketing literature by clarifying VCC's role in sustainable services and offers insights into VCC's causes and effects. It proposes strategies for the express delivery industry to influence consumer behavior through sustainable service practices.
From an emotional experience of mobile food shopping to continued purchase intention: moderating role of e-user expertise
Authors: Ghali Zohra 
Published: October 2024

PurposeThis study examines the role of the emotional experience of mobile food shopping in stimulating perceived values and continued intentions under the moderating role of consumer expertise.Design/methodology/approachWe gathered data from 632 Saudi mobile food shoppers through a web survey and analysed it using structural equation modelling.FindingsThe results showed that emotions (i.e. pleasure, arousal and dominance) significantly affect immersion in the experience of shopping via mobile food applications, which generates significant functional and emotional values and ultimately influences continued intentions. However, they do not have a significant effect on social value. Consumer expertise significantly moderates only the relationships between functional and emotional values with immersion and between immersion and continued intention.Practical implicationsFormulating a marketing strategy based on the emotional dimension is a potentially powerful way to enhance the attractiveness of mobile food applications. Nevertheless, segmenting the market based on consumer expertise is crucial for customising offers.Originality/valueThis study contributes to the literature by integrating pleasure-arousal-dominance theory with the theory of customer value to examine the role of the emotional dimension in the development of perceived values and continued intention to use mobile food ordering applications. Additionally, this study adds to the literature by examining the moderating role of user expertise in these relationships.
Role of social comparison orientation on financial management behavior in a developing nation: examining the mediating role of financial self-efficacy and the moderating effect of financial socialization
Authors: Ahamed AFM Jalal , Limbu Yam B. 
Published: October 2024

Purpose
This study aims to explore the impact of social comparison orientation (SCO) on financial management behavior (FMB) in a developing country with a collectivist culture. It examines how SCO is related to FMB directly and through financial self-efficacy (FSE) and how financial socialization (FS) moderates the SCO–FMB relationship.

Design/methodology/approach
Data was collected from 301 adults in Dhaka, Bangladesh, using self-administered survey questionnaires. Mediation and moderation analyses were performed using Smart PLS software.

Findings
The results indicate that SCO was positively associated with FMB. FSE mediates this relationship, enhancing SCO’s positive impact on FMB. Additionally, FS moderates the effect of SCO on FMB, with higher levels of FS strengthening this positive relationship.

Research limitations/implications
The primary implication of this research is the revelation that SCO can positively impact FMB, contrary to traditional views, particularly when FSE mediates the relationship and FS moderates it. The findings suggest that interventions aimed at enhancing FSE and promoting FS can improve FMB. These insights are valuable for financial educators, policymakers and individuals in developing countries seeking to improve financial behavior.

Originality/value
This study makes four significant contributions: first, it demonstrates a positive direct relationship between SCO and FMB. Second, it reveals that FSE mediates the relationship between SCO and FMB. Third, it shows that FS moderates the SCO–FMB relationship. Fourth, it focuses on a sample from the emerging middle class in a developing country representing a collectivist culture, providing unique insights into this dynamic segment.
Hallucination or vision? Establishing reliability and validity of AI-based qualitative analysis of the unified model of activism in the Scottish independence Twitter debate
Authors: Diers-Lawson Audra , Lawson Stuart J. 
Published: October 2024

PurposeThe present study explores both the validation of the unified model of activism and the methodological reliability of the LlamaParsing approach to natural language processing. Theoretically, it applies the unified model of activism within the context of the Scottish independence movement, evaluating its effectiveness in social media environment.Design/methodology/approachMethodologically, it addresses the reliability and validity challenges associated with AI analyses, particularly the issue of AI hallucinations—instances where AI generates seemingly accurate but incorrect information. By employing the LlamaParsing approach and then comparing and contrasting it with a quantitative content coding process, the study demonstrates how context-specific instructions can enhance the accuracy of AI analyses.FindingsThe findings indicate this approach not only tests and extends the unified model of activism but also offers a robust methodological framework for using NLP and RAG in qualitative research. This dual focus underscores the potential of AI to provide systematic and theoretically valuable insights while highlighting the importance of mitigating its limitations.Originality/valueThis study represents a cutting-edge approach to qualitative data analysis, theory development, and theory testing in communication using a tool that was developed in 2024.
The impact of company size on dual VET quality in Spanish companies
Authors: Rodríguez-Pérez Sara , Barrientos-Sánchez Daniel , Torres-Sánchez Mónica , Pineda-Herrero Pilar 
Published: October 2024

PurposeThe purpose of this paper is to provide a comprehensive description and analysis of quality levels with regard to dual Vocational Education and Training (VET) at companies participating in this programme in Spain, with a specific focus on company size.Design/methodology/approachThe study is based on a quantitative cross-sectional analysis, collecting quality indicator data from 829 participating companies through a structured questionnaire. Subsequently, both descriptive and inferential analyses were conducted to address the specific objectives.FindingsThe study reveals that, on the whole, companies implement dual VET with a high level of quality, achieving compliance rates of above 70% in dimensions related to process, resources, staff and training. However, in this study the dimensions of evaluation and synergies showed lower compliance rates, with figures of 47.4 and 25.7%, respectively. Notably, medium-sized and large companies outperformed micro-SMEs and SMEs in training, evaluation and synergies, while SMEs surpassed large companies in resource management. The study provides recommendations for enhancing dual VET in companies.Research limitations/implicationsThe main limitations of this study pertain to an absence of data concerning the distribution of the population by company sizes and a lack of information regarding the specific sectors to which these companies belong.Originality/valueThis study offers significant value, as it provides data on the quality of dual VET in companies considering size as a key factor. These findings are particularly noteworthy given that research on the quality of dual VET in companies remains limited within the scientific literature.
Harnessing the power of artificial intelligence (AI): a paradigm shift in HRM practices for employee sustainable performance
Authors: Chin Ying Sin , Mohamad Abang Azlan , Lo May Chiun 
Published: October 2024

Purpose
This study aims to investigate the interplay between artificial intelligence (AI) integration, organizational digital culture, human resource management (HRM) practices and employee sustainable performance in luxury hotels in Malaysia. It seeks to elucidate how AI adoption influences organizational dynamics, shapes HRM practices and impacts employee sustainable performance over time.

Design/methodology/approach
Using a quantitative approach, survey questionnaires derived from prior research were utilized. Analysis using G*Power software determined an appropriate sample size, with psychometric evaluation validating scale development. Statistical analyses using Statistical Package for Social Sciences (SPSS) 28.0 and SmartPLS 4 confirmed data reliability and validity.

Findings
Out of the five hypotheses, three were supported. A positive relationship was found between AI adoption and employee sustainable performance, highlighting AI’s potential to enhance productivity and job satisfaction. However, the relationship between AI adoption and organizational digital culture was not supported. On the other hand, HRM practices positively influenced employee sustainable performance. In addition, organizational digital culture was positively associated with employee sustainable performance, underscoring the role of digital fluency in driving workforce productivity. Conversely, AI failed to moderate the relationship between HRM practices and employee sustainable performance.

Research limitations/implications
The study’s focus on luxury hotels in Malaysia and its reliance on cross-sectional data, suggesting the need for longitudinal designs and diverse organizational contexts in future research. Comparative studies across sectors and countries could offer insights into variations in AI adoption practices and their impact on organizational performance.

Originality/value
This study contributes to theoretical frameworks by empirically examining complex relationships between AI integration, HRM practices, organizational digital culture and employee performance, emphasizing the importance of considering organizational context and cultural factors in understanding the implications of AI adoption for sustainable performance enhancement.
Mitigating not-invented-here syndrome in consultant knowledge transfer by developing appropriate implementation guidelines
Authors: Suzic Nikola , Vrgović Petar , Forza Cipriano , Chatzimichailidou Mikela 
Published: October 2024

Purpose
This study aims to propose a framework for the development of implementation guidelines (IGs) that can help consultants mitigate not-invented-here (NIH) syndrome during a consultant intervention as a specific type of knowledge transfer.

Design/methodology/approach
The authors adopted a design science research approach for proposing an NIH-mitigating IG development framework. Inspired by findings and rich primary data from two consultant interventions, the authors, through theory building, ground five core principles in the general theory of NIH attitude functions. Finally, the authors revisit two consultant interventions to identify and describe mechanisms that led to the enactment of the principles.

Findings
The proposed framework provides five principles for developing NIH-mitigating IGs. The present research proposes that successful knowledge transfer and the mitigation of NIH syndrome as a prerequisite for this success are conditioned by adequately developed IGs.

Originality/value
The originality and value of the present research lie in the proposed NIH-mitigating IG development framework containing a set of principles for IG development as a proactive rather than reactive approach to NIH mitigation. To the best of the authors’ knowledge, this is the first research to address the problematics of mitigating NIH syndrome in consultant knowledge transfer by focusing on developing appropriate IGs. By developing and implementing IGs based on the proposed framework, a more successful transfer of knowledge from consultants to clients should take place, thus, increasing the value that clients receive from consultancy.
Application of a hybrid fuzzy-based algorithm to investigate the environmental impact of sewer overflow
Authors: Mohandes Saeed Reza , Kaddoura Khalid , Singh Atul Kumar , Elsayed Moustafa Y. , Banihashemi Saeed , Antwi-Afari Maxwell Fordjour , Olawumi Timothy O. , Zayed Tarek 
Published: October 2024

PurposeThis study underscores the critical importance of well-functioning sewer systems in achieving smart and sustainable urban drainage within cities. It specifically targets the pressing issue of sewer overflows (SO), widely recognized for their detrimental impact on the environment and public health. The primary purpose of this research is to bridge significant research gaps by investigating the root causes of SO incidents and comprehending their broader ecological consequences.Design/methodology/approachTo fill research gaps, the study introduces the Multi-Phase Causal Inference Fuzzy-Based Framework (MCIF). MCIF integrates the fuzzy Delphi technique, fuzzy DEMATEL method, fuzzy TOPSIS technique and expert interviews. Drawing on expertise from developed countries, MCIF systematically identifies and prioritizes SO causes, explores causal interrelationships, prioritizes environmental impacts and compiles mitigation strategies.FindingsThe study's findings are multifaceted and substantially contribute to addressing SO challenges. Utilizing the MCIF, the research effectively identifies and prioritizes causal factors behind SO incidents, highlighting their relative significance. Additionally, it unravels intricate causal relationships among key factors such as blockages, flow velocity, infiltration and inflow, under-designed pipe diameter and pipe deformation, holes or collapse, providing a profound insight into the intricate web of influences leading to SO.Originality/valueThis study introduces originality by presenting the innovative MCIF tailored for SO mitigation. The combination of fuzzy techniques, expert input and holistic analysis enriches the existing knowledge. These findings pave the way for informed decision-making and proactive measures to achieve sustainable urban drainage systems.
Filling empty vessels: accountability, responsibility, and corporate leadership
Authors: Nordberg Donald 
Published: October 2024

Purpose
This paper seeks to identify a rounded understanding of two fuzzy terms in wide but muddled use in guiding corporate leadership: accountability and responsibility. Both have deep resonance discussions of strategy and corporate affairs, but their often-confused meanings both inform actions and impede understanding. Each has normative implications for the practice of corporate governance, and yet each, like an empty vessel,[1] leaves practitioners with an unhappy sense of knowing they have a use but not knowing what to do with them.

Design/methodology/approach
This essay examines the varied uses of these terms in academic literature and practitioner discussions, exploring their conflicting meanings through lenses of philosophy, literary writing, and management studies to show how each, in their flux, overlap and diverge.

Findings
The article analyses themes obscured by these muddy waters and clarifies them by speculating on how their ambiguity demands reflexive, thoughtful action and interaction between the parties in absence of clear hierarchy of command or greater authority. How meaningful that interaction is questionable, when the words are so full of meanings without an iterative process of understanding.

Originality/value
Given the prevalence of the ambiguities is usage, clarifying terms is not a realistic option. Instead, this essay proposes that insofar as these concepts reflect abilities, they represent our ability to embrace their ambiguity in a philosophically pragmatic way, and in so doing be able to act accountably and responsibly.
Leading with integrity: illuminating the pathway to positive job outcomes through ethical leadership and CSR
Authors: Iqbal Junaid , Parray Zahoor Ahmad 
Published: October 2024

Purpose
This paper aims to how ethical leadership influences innovative behavior and employee motivation, focusing on the mediating role of corporate social responsibility within the framework of social exchange theory (SET).

Design/methodology/approach
Data were collected from 341 bank employees using convenience sampling, and hypotheses were rigorously tested with SPSS 22.

Findings
The results highlight the significant impact of ethical leadership on enhancing both employee innovation and motivation, with corporate social responsibility initiatives playing a crucial mediating role.

Originality/value
Drawing on SET, the research illustrates how ethical leadership fosters a reciprocal exchange environment, leading to deeper employee engagement and innovation driven by positive corporate social responsibility practices. By advancing theoretical understanding and providing practical insights, this study offers valuable guidance for organizations aiming to leverage ethical leadership and corporate social responsibility to cultivate a workforce that is both innovative and motivated.