bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methyl 6‐Amino‐6‐deoxy‐d‐pyranoside‐Conjugated Platinum(II) Complexes for Glucose Transporter (GLUT)‐Mediated Tumor Targeting: Synthesis, Cytotoxicity, and Cellular Uptake Mechanism
Authors: Li Taoli , Gao Xiangqian , Yang Liu , Shi Yunli , Gao Qingzhi 
Published: May 2016

AbstractMethyl 6‐aminodeoxy‐d‐pyranoside‐derived platinum(II) glycoconjugates were designed and synthesized based on the clinical drug oxaliplatin for glucose transporter (GLUT)‐mediated tumor targeting. In addition to a substantial improvement in water solubility, the conjugates exhibited cytotoxicity similar to or higher than that of oxaliplatin in six different human cancer cell lines. GLUT‐mediated transport of the complexes was investigated with a cell‐based fluorescence competition assay and GLUT‐inhibitor‐mediated cytotoxicity analysis in a GLUT‐overexpressing human colorectal adenocarcinoma (HT29) cell line. The antitumor effect of the aminodeoxypyranoside‐conjugated platinum(II) complexes was found to depend significantly on the GLUT inhibitor, and the cellular uptake of the molecules was regulated by GLUT‐mediated transport. The results from this study demonstrate the potential advantages of aminodeoxypyranosides as sugar motifs for glycoconjugation for Warburg‐effect‐targeted drug design. These fundamental results also support the potential of aminodeoxypyranoside‐conjugated platinum(II) complexes as lead compounds for further preclinical evaluation.
Synthesis of Fluorinated Homoall­ylic Compounds by Fluoroalkyl Radical Mediated Ring Opening of Methylenecyclopropanes
Authors: Xie Huajun , Xu Bo 
Published: May 2016

AbstractThe fluoroalkyl (Rf) radical mediated ring opening of methylenecyclopropanes (MCPs) 1 and subsequent atom transfer were investigated. In the first part, a copper‐initiated radical reaction of Rf–X (X = I, Br) with MCP 1 gave homoallylic halides 2 in excellent yields. Similarly, radical reaction of the RfTMS/CsF/PhI(OCOR)2 system with MCP 1 led to homoallylic alcohol esters 3 in moderate to good yields.
Adjunctive cognitive behavioural treatment for chronic pain couples improves marital satisfaction but not pain management outcomes
Authors: Ramke S. , Sharpe L. , Newton‐John T. 
Published: May 2016

AbstractBackgroundData have consistently shown that patient coping with chronic pain can be affected by various factors associated with the primary relationship, and hence efforts to include the patient's partner in the treatment process have merit. This study evaluated the benefit of adding an adjunctive, couples‐based, cognitive behavioural treatment (CBT) for chronic pain to a standard cognitive behavioural pain management programme.MethodsForty‐five couples were randomly assigned to either an adjunctive couples intervention (n = 19) or the pain programme only (n = 26). All patient participants completed a 3‐week multi‐disciplinary pain management programme, to which their partners were invited to attend one full day. In addition, partners in the adjunctive condition received four, one hour treatment sessions focusing on pain education, patient–partner communication, operant behavioural principles and relapse prevention strategies. Partner sessions for the adjunctive intervention were provided over the telephone.ResultsBy the completion of the pain programme the adjunctive couples intervention demonstrated significant improvements in marital satisfaction for the spouses over and above attendance at the pain management programme alone (p = 0.003). However, spouse involvement did not facilitate any additional response to treatment for pain patients on marital satisfaction, pain, disability or any indices of distress. All treatment gains were maintained at 1 month follow‐up.ConclusionsThese data demonstrate that a brief CBT intervention can significantly improve marital satisfaction for spouses of chronic pain patients, but the treatment does not translate to improvements in function on any outcomes, including marital satisfaction, for patients of chronic pain.What does this study add?

A brief, telephone‐based intervention for couples living with chronic pain is an acceptable format for intervention.

This intervention can significantly improve marital satisfaction for partners of chronic pain patients.

Patients who are already participating in a multidisciplinary pain programme will not obtain further benefit.
Electrochemical Determination of Synephrine by Hydrophilic Interaction Liquid Chromatography Using a Zwitterionic Monolith Column
Authors: Sakai Yuki , Kotani Akira , Umemura Tomonari , Mori Yukiko , Kusu Fumiyo , Yamamoto Kazuhiro , Hakamata Hideki 
Published: May 2016

AbstractA sensitive method for the electrochemical determination of synephrine (SYN) by hydrophilic interaction liquid chromatography (HILIC) has been developed. Optimal chromatographic separation and high sensitive determination by HILIC with electrochemical detection (HILIC‐ECD) was achieved using a sulfobetaine‐type zwitterionic monolith column (100×1.02 mm, i.d.), a mixture of 10 mM sodium phosphate (pH 4) and acetonitrile (20 : 80, v/v) as mobile phase, and a glassy carbon working electrode which was applied with a potential at +1.0 V vs. Ag/AgCl. The chromatographic peak height of SYN was proportional to the concentration from 5.0 µg/L to 1.0 mg/L (r=0.999). The detection limit of SYN (S/N=3) was 3.7 pg on the column. Moreover, the present HILIC‐ECD could be applied to the accurate and precise determination of SYN in Aurantii nobilis Pericarpium. In conclusion, we have demonstrated that an ECD is one of useful detection methods applicable to HILIC.
A revised soil erosion budget for India: role of reservoir sedimentation and land‐use protection measures
Authors: Sharda Vishwa N. , Ojasvi Prabhat R. 
Published: May 2016

AbstractAmong the different controls of erosion budget at basin level, the relative impact of dams and land management is yet to be investigated. In this paper, the impact of dams on sediment yield has been assessed by using a conceptual modelling framework which considers the gross erosion and the cascade of dams constructed on a river network. The sediment budget has been estimated based on the gross erosion, deposition of sediment in reservoirs, and sediment yields of 23 mainland river basins of India. The gross erosion of the country is estimated as 5.11 ± 0.4 Gt yr−1 or 1559 t km−2 yr−1, out of which 34.1 ± 12% of the total eroded soil is deposited in the reservoirs, 22.9 ± 29% is discharged outside the country (mainly to oceans), and the remaining 43.0 ± 41% is displaced within the river basins. The river basins of northern India contribute about 81% of the total sediment yield from landmass while the share of southern river basins is 19%. The components of revised sediment budget for India are prominently influenced by the sediment trapped in reservoirs and the treatment of catchment areas by soil and water conservation measures. Analysis of sediment deposition in 4937 reservoirs indicated the average annual percentage capacity loss as 1.04% though it varies from 0.8% to >2% per year in smaller dams (1–50 Mm3 capacity) and from <0.5% to 0.8% per year in larger dams (51 to >1000 Mm3 capacity). Siltation of smaller dams poses a serious threat to their ecosystem services as they cater to a wider population for domestic, agricultural, and industrial purposes. Amongst the environment controls, land use significantly impacts the gross erosion rate and specific sediment yield as compared to climatic and topographic parameters. However, to analyse their integrated effect on the complex processes of sediment fluxes in a basin, further research efforts are needed. Copyright © 2016 John Wiley & Sons, Ltd.
Advances in shrub‐willow crops for bioenergy, renewable products, and environmental benefits
Authors: Volk Timothy A. , Heavey Justin P. , Eisenbies Mark H. 
Published: May 2016

AbstractShort‐rotation coppice systems like shrub willow are projected to be an important source of biomass in the United States for the production of bioenergy, biofuels, and renewable bio‐based products, with the potential for auxiliary environmental benefits and multifunctional systems. Almost three decades of research has focused on the development of shrub willow crops for biomass and ecosystem services. The current expansion of willow in New York State (about 500 ha) for the production of renewable power and heat has been possible because of incentive programs offered by the federal government, commitments by end users, the development of reliable harvesting systems, and extension services offered to growers. Improvements in the economics of the system are expected as willow production expands further, which should help lower establishment costs, enhance crop management options and increase efficiencies in harvesting and logistics. Deploying willow in multifunctional value‐added systems provides opportunities for both potential producers and end users to learn about the system and the quality of the biomass feedstock, which in turn will help overcome barriers to expansion.
High‐order strand grid methods for low‐speed and incompressible flows
Authors: Thorne Jonathan , Katz Aaron , Tong Oisin , Yanagita Yushi , Tamaki Yoshiharu , Delaney Keegan 
Published: May 2016

SummaryA novel high‐order finite volume scheme using flux correction methods in conjunction with structured finite differences is extended to low Mach and incompressible flows on strand grids. Flux correction achieves a high order by explicitly canceling low‐order truncation error terms across finite volume faces and is applied in unstructured layers of the strand grid. The layers are then coupled together using a source term containing summation‐by‐parts finite differences in the strand direction. A preconditioner is employed to extend the method to low speed and incompressible flows. We further extend the method to turbulent flows with the Spalart–Allmaras model. Laminar flow test cases indicate improvements in accuracy and convergence using the high‐order preconditioned method, while turbulent body‐of‐revolution flow results show improvements in only some cases, perhaps because of dominant errors arising from the turbulence model itself. Copyright © 2016 John Wiley & Sons, Ltd.
Axon density and axon orientation dispersion in children born preterm
Authors: Kelly Claire E. , Thompson Deanne K. , Chen Jian , Leemans Alexander , Adamson Christopher L. , Inder Terrie E. , Cheong Jeanie L.Y. , Doyle Lex W. , Anderson Peter J. 
Published: May 2016

AbstractBackgroundVery preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes.MethodsFA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 control 7‐year‐olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight, and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic, and behavioral outcomes) using Tract‐Based Spatial Statistics.ResultsCompared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion, and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children.ConclusionsFA and NODDI measures distinguished VPT children from controls and were associated with neonatal brain abnormalities and neurodevelopmental outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity.Hum Brain Mapp 37:3080–3102, 2016. ©2016 Wiley Periodicals, Inc.
Data‐driven analysis of simultaneous EEG/fMRI reveals neurophysiological phenotypes of impulse control
Authors: Schmüser Lena , Sebastian Alexandra , Mobascher Arian , Lieb Klaus , Feige Bernd , Tüscher Oliver 
Published: May 2016

AbstractResponse inhibition is the ability to suppress inadequate but prepotent or ongoing response tendencies. A fronto‐striatal network is involved in these processes. Between‐subject differences in the intra‐individual variability have been suggested to constitute a key to pathological processes underlying impulse control disorders. Single‐trial EEG/fMRI analysis allows to increase sensitivity for inter‐individual differences by incorporating intra‐individual variability. Thirty‐eight healthy subjects performed a visual Go/Nogo task during simultaneous EEG/fMRI. Of 38 healthy subjects, 21 subjects reliably showed Nogo‐related ICs (Nogo‐IC‐positive) while 17 subjects (Nogo‐IC‐negative) did not. Comparing both groups revealed differences on various levels: On trait level, Nogo‐IC‐negative subjects scored higher on questionnaires regarding attention deficit/hyperactivity disorder; on a behavioral level, they displayed slower response times (RT) and higher intra‐individual RT variability while both groups did not differ in their inhibitory performance. On the neurophysiological level, Nogo‐IC‐negative subjects showed a hyperactivation of left inferior frontal cortex/insula and left putamen as well as significantly reduced P3 amplitudes. Thus, a data‐driven approach for IC classification and the resulting presence or absence of early Nogo‐specific ICs as criterion for group selection revealed group differences at behavioral and neurophysiological levels. This may indicate electrophysiological phenotypes characterized by inter‐individual variations of neural and behavioral correlates of impulse control. We demonstrated that the inter‐individual difference in an electrophysiological correlate of response inhibition is correlated with distinct, potentially compensatory neural activity. This may suggest the existence of electrophysiologically dissociable phenotypes of behavioral and neural motor response inhibition with the Nogo‐IC‐positive phenotype possibly providing protection against impulsivity‐related dysfunction. Hum Brain Mapp 37:3114–3136, 2016. © 2016 Wiley Periodicals, Inc.
Pretreatment computed tomographic gross tumor volume as predictor of persistence of tracheostomy and percutaneous endoscopic gastrostomy tube in patients undergoing larynx preservation
Authors: Hurst Newton J. , Pereira Lucio M. , Dominello Michael M. , Dyson Gregory , Laszewski Pamela , Robinette Natasha , Lin Ho‐Sheng , Yoo George , Sukari Ammar , Kim Harold 
Published: May 2016

ABSTRACTBackgroundAlthough larynx preservation affords patients improvements in laryngectomy‐free survival, little has been reported regarding the functional outcomes after larynx preservation. The purpose of this study was to report the predictive value of pretreatment CT‐gross tumor volume (GTV) for persistence of tracheostomy and percutaneous endoscopic gastrostomy (PEG) tube in larynx preservation patients.MethodsEach patient had a CT scan before initiation of therapy and the GTV was contoured.ResultsUsing recursive partitioning analysis (RPA), threshold GTVs of 27.16 cc and 12 cc were identified for association of time with tracheostomy and PEG tube, respectively. Median (95% confidence interval [CI]) times above and below these thresholds were 1.84 (1.06–not reached [NR]) and 0.75 (0.63–1.26) years, respectively (p = .03) for time with tracheostomy and 1.75 (1.34–NR) and 0.84 (0.46–NR) years, respectively (p = 0.10) for time with PEG tube.ConclusionThis study demonstrates that pretreatment CT‐GTV is predictive of an approximately 2.5‐fold and approximately 2‐fold, respectively, increase in time with tracheostomy and PEG tube. © 2016 Wiley Periodicals, Inc. Head Neck 38: First–1458, 2016
Effects of in vitro exposure to butylparaben and di‐(2 ethylhexyl) phthalate, alone or in combination, on ovarian function
Authors: Guerra Marina T. , Furlong Hayley C. , Kempinas Wilma G. , Foster Warren G. 
Published: May 2016

AbstractParabens and phthalates are commercial chemicals widely used in the manufacture of industrial and consumer products frequently found as contaminants in biological fluids. We evaluated the effects of di‐(2‐ethylhexyl) phthalate (DEHP) (ranging from 10–9 to 10–7 m [1–100 nm; 0.39–39 ng ml–1]) and butylparaben (BP) (ranging from 10–8 to 10–5 m [10 nm–10 μm; 1.9 ng ml–1 to 1.9 μg ml–1]), alone and in combination, on isolated mouse preantral follicle and human granulosa cell (hGC) cultures to study direct effects on follicle growth and ovarian steroidogenesis. Our results revealed that, in follicle culture, DEHP and BP attenuate estradiol output but only when present together. DEHP decreases progesterone concentrations in the spent media of hGC cultures, an effect that was attenuated when BP was added together with DEHP. Although changes in steroidogenesis were observed, no effects on follicular development or survival were noted in the culture systems. We suggest that BP and DEHP act with additive effect to decrease estradiol production whereas at later stages of follicle development BP blocks the effect of DEHP in hGCs resulting in decreased progesterone output. Taken together our results suggest that DEHP and BP adversely affect steroidogenesis from the preantral stage onward and the effects of these chemicals are both stage‐dependent and modified by co‐exposure. Copyright © 2016 John Wiley & Sons, Ltd.
“Filarial dance sign” real‐time ultrasound diagnosis of filarial oophoritis
Authors: Panditi Surekha , Shelke Ashwini G. , Thummalakunta Laxmi Narasimha Praveen 
Published: May 2016

ABSTRACTFilariasis is a parasitic disease caused by Filarial nematodes (Wuchereria bancrofti, Brugia malayi, and Brugia timori) that commonly causes lymphatic obstruction resulting in edema and increase in the size of the affected organ. Filariasis is diagnosed by identifying microfilariae on Giemsa stain. The immunochromatographic card test is diagnostic. Ultrasound is the imaging modality of choice for detecting adult filarial worms/microfilaria in the lymphatic system, which are responsible for the classic “filarial dance sign” caused by twirling movements of the microfilariae. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:500–501, 2016
The impact of canopy managements on grape and wine composition of cv. ‘Istrian Malvasia’ (Vitis vinifera L.)
Authors: Rescic Jan , Mikulic‐Petkovsek Maja , Rusjan Denis 
Published: May 2016

AbstractBACKGROUNDThe interest in producing wines preferred by consumers increases the need for improving practices to modify grape and wine composition. The aim of this study was to assess the impacts of three different canopy management measures, (1) early leaf removal in the cluster zone, (2) removal of young leaves above the second pair of wires and (3) Double Maturation Raisonnée, on the yield and chemical composition of ‘Istrian Malvasia’ grape and wine.RESULTSDouble Maturation Raisonnée had a significantly greater impact on phenolic compounds, while the highest soluble solids (24.3 and 23.5 °Brix) and titratable acidity (7.0 and 7.1 g L−1) were measured at early leaf removal. Leaf removal at véraison caused an unexpected augmentation of flavonols in the berry skin. Early leaf removal resulted in significantly lower extracts of wine. Nevertheless, they reached the highest mark (16.5 out of 20.0 points) in sensory evaluation compared with leaf removal at véraison and Double Maturation Raisonnée (15.0 points) and control (16.0 points).CONCLUSIONLeaf removal at véraison and Double Maturation Raisonnée improved the phenolic composition of wine, producing a full‐bodied wine. On the other hand, early leaf removal significantly augmented the yield and titratable acidity, hydroxycinnamic acids and flavanols of wine, which might have led to a fresher but less‐bodied wine. © 2016 Society of Chemical Industry
Ionic‐liquid‐based dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography for the forensic determination of methamphetamine in human urine
Authors: Wang Ruifeng , Qi Xiujuan , Zhao Lei , Liu Shimin , Gao Shuang , Ma Xiangyuan , Deng Youquan 
Published: May 2016

Determination of methamphetamine in forensic laboratories is a major issue due to its health and social harm. In this work, a simple, sensitive, and environmentally friendly method based on ionic liquid dispersive liquid–liquid microextraction combined with high‐performance liquid chromatography was established for the analysis of methamphetamine in human urine. 1‐Octyl‐3‐methylimidazolium hexafluorophosphate with the help of disperser solvent methanol was selected as the microextraction solvent in this process. Various parameters affecting the extraction efficiency of methamphetamine were investigated systemically, including extraction solvent and its volume, disperser solvent and its volume, sample pH, extraction temperature, and centrifugal time. Under the optimized conditions, a good linearity was obtained in the concentration range of 10–1000 ng/mL with determination coefficient >0.99. The limit of detection calculated at a signal‐to‐noise ratio of 3 was 1.7 ng/mL and the relative standard deviations for six replicate experiments at three different concentration levels of 100, 500, and 1000 ng/mL were 6.4, 4.5, and 4.7%, respectively. Meanwhile, up to 220‐fold enrichment factor of methamphetamine and acceptable extraction recovery (>80.0%) could be achieved. Furthermore, this method has been successfully employed for the sensitive detection of a urine sample from a suspected drug abuser.
Formation of Highly Aligned Collagen Nanofibers by Continuous Cyclic Stretch of a Collagen Hydrogel Sheet
Authors: Nam Eunryel , Lee Won Chul , Takeuchi Shoji 
Published: May 2016

A collagen sheet with highly aligned collagen fibers is fabricated by continuous cyclic stretch. The rearrangement of the collagen fibers depends on the different process parameters of the cyclic stretch, including magnitude, frequency, and period of stretch. The collagen fibers are aligned perpendicularly to the direction of the stretch. Corneal stromal cells and smooth muscle cells cultivated on the highly aligned collagen sheet show alignment along the collagen fibers without the stretch during culture. Thus, the sheet can be a suitable scaffold for use in regenerative medicine.
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