bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of in vitro bioassays and chemical screening to assess the impact of a minimally processed vegetable facility on wastewater quality
Authors: Aneck-Hahn N. H. , Van Zijl M. C. , Quinn L. , Swiegelaar C. , Nhlapo N. , de Bruin W. , Korsten L. 
Published: September 2024

Fruit- and vegetable-processing facilities may contaminate wastewater via contaminants found in the produce and disinfecting chemicals used. These contaminants may include agrochemicals, pesticides, and disinfectants such as chlorine and quaternary ammonium compounds (QACs). Some compounds may exhibit harmful endocrine-disrupting activity. This study investigated the impact of a minimally processed vegetable facility on wastewater quality via in vitro bioassays and chemical screening. Estrogen activity was assessed via a yeast estrogen screen (YES), and (anti-)androgenic and glucocorticoid activities were evaluated via an MDA-kb2 reporter gene assay. The samples were screened via gas and liquid chromatography–tandem mass spectrometry (GC-MS/MS and LC-MS/MS) to identify target compounds, and GC coupled with time-of-flight mass spectrometry (GC-TOFMS) was used for non-targeted screening. Sample complexity and chemical profiles were assessed using GC-TOFMS. Estrogenic activity was detected in 16 samples (n = 24) with an upper limit of 595 ± 37 ng/L estradiol equivalents (EEqs). The final wastewater before discharge had an EEq of 0.23 ng/L, which is within the ecological effect-based trigger value range for the estrogenic activity of wastewater (0.2–0.4 ng/L EEq). Androgenic activity was detected in one sample with a dihydrotestosterone equivalent (DHTEq) value of 10 ± 2.7 ng/L. No antiandrogenic activity was detected. The GC-MS/MS and LC-MS/MS results indicated the presence of multiple pesticides, nonylphenols, triclocarban, and triclosan. Many of these compounds exhibit estrogenic activity, which may explain the positive YES assay findings. These findings showed that wastewater from the facility contained detergents, disinfectants, and pesticides and displayed hormonal activity. Food-processing facilities release large volumes of wastewater, which may affect the quality of the water eventually being discharged into the environment. We recommend expanding conventional water quality monitoring efforts to include additional factors like endocrine activity and disinfectant byproducts.
A prospective study to evaluate the role of repetitive trans-cranial magnetic stimulation in treatment of chronic low back pain
Authors: Shashivadhanan  , Tiwari Mannu , Singhal Ankit , M. Nandish , Dhanwade Sachin , Mishra Ritwik , Porwal Neerav 
Published: September 2024

Introduction: Chronic Low Back Pain (CLBP) is a disabling musculoskeletal condition with a high prevalence in developing and developed countries. There are many treatment modalities but none of them provides a satisfactory and consistent cure. Recently focus has shifted to neuromodulation to cure chronic pains. The U.S. Food and Drug Administration (FDA) approved the use of Repetitive TMS (rTMS) in the management of Pain in 2013. Since then, centres across the world have been using Transcranial Magnetic Stimulation (TMS) as a noninvasive modality for the treatment of various pain conditions. rTMS is a variation of TMS where stimulation is provided in sessions to create long-term excitation in the brain cortex. Evidence on the effectiveness of rTMS for CLBP is scarce due to limited rigorous clinical trials. This study is the first of its kind undertaken in India to critically analyze the role of rTMS in the treatment of CLBP.
Materials & Methods: In this single institutional prospective, single-blind study, we enrolled 40 patients of CLBP sharing similar clinical profiles. They were divided into a test group and a sham group. In the test group patients were given rTMS in addition to conventional treatment while in the sham group, patients were taken through the procedure of rTMS without actually being administered it. A figure-of-eight-shaped coil was used focusing on the Left M1 area and Dorsolateral prefrontal cortex to administer the rTMS by a trained physician. Visual Analogue Scores (VAS) were noted before and after the procedure. Each patient was continuously monitored during the procedure for any side effects. Subsequently, they were interviewed and followed up for 6 months. At the end of 6 months, data was compiled and conclusions were drawn.
Result: In our study, we found that 90 per cent of patients in the test group reported a reduction in VAS score by 30 per cent reduction while the remaining had a 20 per cent reduction in pain scores. 90 per cent of subjects in the sham group reported a marginal improvement in VAS score which can be attributed to the placebo effect. Most patients in the test group reported an improvement in quality of life at the end of six months. None of the patients suffered any untoward side effects during or after the procedure.
Conclusion: Based on our study we conclude that rTMS is a safe procedure and it can be used as a modality in treating CLBP with satisfactory outcomes. Although the sample size was small, it is the first study of its kind undertaken in India to evaluate the role of rTMS-based neuromodulation in treating this chronic disabling condition. However, to be accepted as a standard of care for CLBP it will require further multi-institutional robust clinical trials with long-term follow-up.
Cirurgia de troca valvar: avaliação comparativa entre válvulas mecânicas e biológicas
Authors: Silva Guilherme Henrique do Nascimento , Silva Liliane Silveira da , Nascimento Beatriz Bittencourt Oliveira , Guimarães Neto João Carvalho , Carvalho Victor Pinheiro Ribeiro de , Silveira Filho Alex José , Cruz Paulo Henrique Brito Poderoso , Pires Filipe de Menezes Freire , Monteiro Fernando , Costa Filho João Bosco da , Santos Rodrigo Rocha dos 
Published: September 2024

Introdução: A cirurgia de troca valvar é um procedimento crucial para o tratamento de diversas valvopatias cardíacas, como a estenose aórtica e a insuficiência mitral. A intervenção cirúrgica visa substituir a válvula danificada por uma prótese, restaurando a função normal do coração e melhorando significativamente a qualidade de vida dos pacientes. Objetivo: Comparar os benefícios e desvantagens prognósticas na realização de procedimento de troca valvar com utilização de válvula mecânica ou biológica. Métodos: Trata-se de uma revisão de literatura na qual foram realizadas buscas nas bases de dados “Medline” e “Lilacs” via Biblioteca Virtual de Saúde (BVS). Os descritores utilizados foram “Substituição valvar” AND “Tipos” AND “Cirurgia ". Foram incluídos artigos originais, nos idiomas inglês e português, publicados nos últimos 5 anos (2019-2024). Foram analisados 8 artigos, os quais preencheram os critérios de elegibilidade e foram selecionados para o resumo. Resultados: .As válvulas mecânicas, devido à sua longevidade, são preferíveis para pacientes jovens, mas exigem anticoagulação contínua, aumentando o risco de complicações hemorrágicas. As válvulas biológicas, por sua vez, têm a vantagem de menor necessidade de anticoagulação, reduzindo complicações associadas, mas possuem durabilidade inferior, geralmente necessitando de substituição em 10 a 20 anos. Conclusão: A escolha entre válvulas mecânicas e biológicas depende de vários fatores, incluindo a idade do paciente, a presença de outras condições médicas e as preferências individuais. Ambas as opções têm demonstrado eficácia em restaurar a função valvar e melhorar a qualidade de vida dos pacientes.
Pengaruh Serbuk Kaca Sebagai Substitusi Parsial Semen terhadap Kuat Tekan Beton Alir
Authors: Arsasuta Faris , Rochmah Nurul 
Published: September 2024

AbstractIn the current construction development, concrete is the main material used because of its advantages in strength and durability. One of the innovations in the use of concrete is flow concrete, which allows use without compactors and has optimal viscosity. The use of glass powder as a partial substitution of cement is an attractive alternative because of its potential in improving concrete properties. Glass powder has a fairly large silica (SiO2) content of 75%. Silica has a strong relationship with the compressive strength of concrete. Proper silica in concrete mix can increase the compressive strength of concrete. This study aims to determine the effect of glass powder with variations of 0%, 6%, 8%, 10%, 12% on the compressive strength of flow concrete with a proportion of superplasticizer 1.5%. Compressive strength testing is carried out when concrete reaches the age of 7, 21, 28 days using cylindrical specimens measuring 15 × 30 cm. From the test results, the highest compressive strength value was obtained at 28 days concrete age, namely in an 8% glass powder mixture of 25.61 Mpa and the lowest compressive strength value in a 12% glass powder mixture of 21.26 Mpa. Based on the results of this study, it can be concluded that glass powder as a partial substitution of cement can increase the compressive strength of flow concrete with an optimal glass powder mixture of 8%. Keywords— Flowing Concrete, Glass Powder, Compressive Strength
KAJIAN OPTIMASI KOMBINASI LDPE, CPO, BAN DALAM SEBAGAI PENGIKAT TERHADAP CAMPURAN AC-WC
Authors: Refiyanni Meidia , Opirina Lissa , Ikhsan Muhammad , Azwanda Azwanda , Satria Andrisman , Tripoli Bambang 
Published: September 2024

Abstract Infrastructure development continues to increase, especially on highway pavement, requiring a lot of materials such as coarse aggregate, fine aggregate, filler and asphalt (Pen 60/70) as a binder. However, the depletion of petroleum reserves which has an impact on the availability of asphalt has encouraged innovation to reduce its use. One potential innovation is the use of a combination of plastic waste (LDPE), Crude Palm Oil (CPO), and used inner tubes as an alternative binding material. This research examines the optimization of the use of this combination in the Asphalt Concrete-Wearing Course (AC-WC) mixture. Indonesia, as a tropical country with a significant area of oil palm plantations, produces abundant CPO. In addition, high use of plastic produces plastic waste that is difficult to decompose, and Indonesia is one of the largest contributors of plastic waste in the world. By utilizing this waste in road pavement, this research seeks to reduce environmental impacts while providing alternative solutions for pavement materials. Tests were carried out with three variations, namely V1 = 3% LDPE : 2% CPO : 10% inner tube : 85% pen 60/70; V2 = 4%LDPE : 2%CPO : 10% inner tube : 84% pen 60/70; V3 = 5%LDPE : 2%CPO : 10% inner tube : 83% pen 60/70 to determine the characteristics of stability, flow, VMA, Void in Mix (VIM), VFB, and Marshall Quotient (MQ). The test results show that the Optimum Asphalt Content (KAO) value is 5.5%. All variations meet the minimum stability specifications set by Bina Marga(2018). Keywords : LDPE, CPO, Karet Ban Dalam, Pen 60/70, AC-WC
SEBOTOK WHARF CONSTRUCTION RISK MANAGEMENT ANALYSIS SUMBAWA WEST NUSA TENGGARA
Authors: Junna Isra 
Published: September 2024

Abstract: The construction of the Sebotok Pier in Sebotok Village, Labuhan Badas Subdistrict, was carried out for the 2017 Fiscal Year, with Contract Number 027/34/PPK-DISHUB/VIII/2017 dated 21 August 2017 with an implementation period of 125 calendar days (from 21 August to 23 December 2017) and maintenance period of 180 calendar days. Contract Addendum Number 027/63.1/PPK-DISHUB/XII/2017, December 11 2017 (August 21 to January 12 2018). The work was 100% complete and a Provisional Hand Over (PHO) was carried out on January 23 2018. Based on information that there was damage to the Causeway (collapse of the talud masonry wall) in March 2019 and repairs had been carried out in the same month. The Construction Experts Team aims to provide technical justification related to the Sebotok Wharf Construction work, Labuhan Badas District. Referring to the Decree of the Inspector of Sumbawa Regency Number 732.a.Year 2019 concerning the Appointment and Determination of the Amount of Honorarium for the Team of Construction Experts in the Investigation Audit of the Causeway Work for the Sebotok Wharf Development, Sumbawa Regency for the 2017 Fiscal Year addressed to the Team of Construction Experts. The Construction Expert Team conducts field data collection; measuring the dimensions of the causeway construction, checking the physical condition of the causeway building, taking material samples and laboratory tests, interviewing (village officials, community leaders, several people who were directly involved as workers in the implementation of the causeway construction) and documentation. From the results of the analysis it can be concluded that masonry construction in causeway work with dimensions of width (B) 0.40 m, and height (H) 2.16 m a stability safety score of <1.5 is obtained so that the construction is declared UNSAFE. Keywords: Justification, Wharf, Construction Services
Topological analysis of the industrial product body
Authors: Ghazi Hamad Liqaa 
Published: September 2024

تعنى الطوبولوجيا بدراسة البنى التصميمية من خلال ابعاد مختلفة مما يتيح للمصمم التحكم بسلوكيات تلك البنى ، لذلك يعتبر مفهوم الأبعاد أحد اساسيات تكوين المنتج الصناعي ومحاولته للسيطرة على المادة في التصميم وبالتالي فإن توجيه هذه ألابعاد إحدى أدوات الطوبولوجيا الهندسية ؛ والذي يعبر عن مفهوم أساسي في دراسة السطوح من خلال التمييز بين ما هو خارجي وداخلي .
مشكلة البحث: ماهية الاساليب التقنية الحديثة والمطبقة بخصائص طوبولوجية في تصميم هيئة المنتج الصناعي؟
هدف البحث: الوصول الى خصائص تقنيات التشكيل الطوبولوجي لهيئة المنتج الصناعي .
تضمن الاطار النظري : التعرف على ماهية الطوبولوجيا ومدى أهميتها في النظام التصميمي ، وماهو المفهوم الشكلي للمنتج الصناعي طوبولوجيا، وماهية أهم تقنيات التصميم الطوبولوجي . أما اهم النتائج والاستنتاجات التي وصلت اليها الباحثة فكانت :
1- تعتبر المرونه من أهم خصائص التصميم الطوبولوجي ضمن ثنائية الثبات والتغيير ، ومن ثم خاصية التكامل مابين المستوى الشكلي والمستوى الوظيفي لأشكال إتسمت بالمالانهاية ، لتأتي خاصية السيولة التي تراعي رغبة الفرد وتتغير مع تغيير الزمان والمكان.
2- تنوعت التقنيات تبعا لتنوع الخصائص فأصبحت المنطويات والملتويات هيئة تقنيات طوبولوجية يتعامل معها المصمم ،فلا وجود للأشكال المنتظمة ولا وجود للحواف المحددة والسطوح المستوية .
Textual transformation in international logo designs
Authors: Mohsin Yasir Bushra , Jassim Hussein Banana Bassam , Kareem Hasan Maysaa 
Published: September 2024

تمثل الشعارات بهيئتها الشكلية بطاقة تعريفية وهوية للمؤسسة التابعة لها، فهي وسيلتها البصرية في الاتصال والتواصل مع المتلقي ، لذا كان التأكيد من هذه المؤسسات على تكوين تصميمي مثالي لهذه الهوية بهيئة مبسطة تعكس الفكرة للمتلقي بشكل مباشر،فكان إن مرت العديد من تصاميم الشعارات العالمية بمراحل من التحول الى ان وصلت الى اعتماد شكل بصري من نص كتابي فقط ، وهذا ما يمثله البحث الحالي من دراسة اعتمدت المنهج التحليلي لعدد من الشعارات العالمية التي مرت بتلك التحولات النصية، فتمثلت مشكلة البحث في التساؤل الاتي (ما اهمية التحول البصري النصي في تصميم الشعارات العالمية، ودوره الوظيفي)؟ ، وتحدد هدف البحث في (التعرف على التحولات البصرية النصية للشعارات العالمية ودورها في تحقيق الهدف الوظيفي المطلوب)، وتناول البحث في متنه مواضيع مثل المؤثر المباشر لهذه التحولات، والهوية والصورة الذهنية لتصميم الشعارات، و التبسيط المظهري ، إضافة الى الهدف الوظيفي للشعارات النصية وسبل تحقيقه، وقد خرج البحث بمجموعة من النتائج ابرزها :- تحقق وبشكل بارز اسلوب الحداثة وتأثيرات المدارس الفنية في التحولات النصية التي مرت على تصميم الشعارات العالمية، كذلك كونت التحولات النصية في تصميم الشعارات علامات تجارية مميزة بصرياً، قادرة على التعريف بهوية المؤسسة التي تمثلها بشكل مباشر بعد تبني البساطة في بناءها التصميمي القائم على الايجاز والابتعاد عن الإطالة والإسهاب البصري .
KEMAMPUAN MENGHAMBAT DARI PEPTIDA SIKLIK YANG DIHASILKAN Prochloron didemni TERHADAP RESEPTOR KANKER KOLOREKTAL DAN PENYAKIT VIRUS DENGAN PENDEKATAN ANALISIS IN SILICO
Authors: Rumengan Inneke , Goei Angelina , Lintang Rosita , Sinjal Chatrien , Pangemanan Trezya 
Published: September 2024

Mikroba endosimbion pada golongan Tunikata dari kelas Ascidiacea sudah ditemukan di Pesisir Malalayang, Teluk Manado. Prochloron didemni sebagai salah satu spesies mikroba fotosimbion pada ascidia dilaporkan menghasilkan berbagai peptida siklik seperti patelamida A, B, C, D, E, F, G dan H, serta ulitiasiklamida. Sebagai bagian dari eksplorasi potensi molekuler mikroba endosimbion tersebut, telah dilakukan analisis in silico untuk prediksi awal kemampuan hambat senyawa-senyawa peptida siklik tersebut terhadap reseptor-reseptor pada kanker kolorektal dan virus dengue dengan menggunakan perangkat lunak AutoDock Vina. Afinitas pengikatan molekul ligan terhadap reseptor yang ditunjukkan dengan nilai ΔG. Besaran nilai ΔG terkecil diperoleh dari hasil penambatan patelamida A terhadap reseptor virus dengue (ΔG = -14,84), jelas mengindikasikan betapa efektifnya senyawa ini dapat menghambat virus tersebut. Kemampuan ulitiasiklamida juga ternyata sama kuatnya dalam menghambat kedua reseptor kanker kolorektal (ΔG = -14,1 dan -14,42), setara dengan obat, irinotecan. Kemampuan antikanker dan antivirus juga dimiliki oleh senyawa-senyawa patelamida lainnya, sehingga dapat disimpulkan peptida siklik yang dihasilkan oleh mikroba endosimbion P. didemni mempunyai peluang untuk dikembangkan sebagai obat antikanker dan antivirus. Tentu saja, dalam hal ini perlu dilakukan uji-uji klinik standar ke depan.
Kata kunci: peptida siklik, Prochloron didemni, in silico, antikanker, antivirus
Pemanfaatan Aplikasi Akuntansi Berbasis Android atau IOS untuk Penyusunan Laporan Keuangan bagi UMKM Jakpreneur Jakarta Utara (PPKUKM Jakarta Utara)
Authors: Rusli Devvy , Zulfiati Lies , Chusnah Flourien Nurul , Supriati Diana , Sulistyowati Sulistyowati 
Published: September 2024

Tujuan pelaksanaan kegiatan pengabdian kepada masyarakat adalah untuk meningkatkan pemahaman pelaku Usaha Menengah Kecil dan Mikro (UMKM) tentang aplikasi yang terbuka untuk umum tanpa berbayar di Google Playstore atau di App Store. Pelaku UMKM didorong menggunakan salah satu aplikasi akuntansi yang gratis dengan ponsel cerdas Android atau IOS mereka. Kami memilih untuk memperkenalkan aplikasi SI APIK karena SI APIK akan membantu pelaku UMKM menghasilkan laporan keuangan secara mudah. Berdasarkan survey awal, kami menyimpulkan bahwa pelaku UMKM tidak mengetahui aplikasi SI APIK. Kegiatan pengabdian kepada masyarakat dengan memberikan pengetahuan tentang bagaimana mengoperasikan aplikasi SI APIK dalam menghasilkan laporan keuangan. Mitra kegiatan pengabdian kepada masyarakat adalah UMKM JakPrenuer Jakarta Utara (PPKUK). Peserta kegiatan ini sudah mengenal fitur-fitur SI APIK dan mengetahui prosedur pencatatan transaksi dengan aplikasi SI APIK.
MORBIDADE POR DIABETES MELLITUS NO BRASIL: UM ESTUDO EPIDEMIOLÓGICO
Authors: Figueiredo Neto Aloisio Lula , Icó da Silva Neto Caetano , Silva Santos Rafael , França Nascimento Maria Luiza , Santos Cleydson , Soares Leite Fernanda Gabryelle , Possidônio Ferreira José Fabio , Silva Damasceno Richele 
Published: September 2024

Introdução: O diabetes mellitus é uma condição metabólica crônica caracterizada por níveis elevados de glicose no sangue, sendo classificado principalmente em diabetes tipo 1 (DM1) e diabetes tipo 2 (DM2). O DM2, o mais prevalente entre os idosos, está frequentemente associado à obesidade e ao envelhecimento, manifestando-se gradualmente com resistência à insulina e insuficiência parcial na secreção de insulina pelas células beta (β). Por outro lado, o DM1 resulta da deficiência autoimune das células. Desse modo, o objetivo deste trabalho é investigar a epidemiologia no Brasil por DM, de janeiro de 2013 a junho de 2024. Metodologia: Foi realizado um estudo epidemiológico descritivo utilizando dados do departamento de informações de saúde do SUS. As variáveis analisadas incluíram internações, óbitos, idade, sexo, região e média de duração das hospitalizações. Resultados: Nesse sentido, os 1.402.174 dados coletados neste estudo, tornou evidente que no Brasil tivemos mais internações na região sudeste com 502,801 casos, registrou-se a mesma, ainda, com maior número de óbitos, sendo esses 23.255, e também maiores custos de serviço hospitalares, sendo ele R$409.727.657,43 com 3.320.043 dias de permanência de internações. pacientes com 60 à 64 anos, foram os mais acometidos, esses dados sugerem que a incidência de DM e suas complicações tende a aumentar com a idade, o que pode estar relacionado ao acúmulo de fatores de risco. Em relação à cor/raça mais pacientes pardos são mais acometidos. Conclusão: Portanto, o Diabetes Mellitus afeta uma grande parte da população e sua prevalência tem aumentado com o tempo. É crucial destacar que, embora não exista cura para a diabetes, seu manejo adequado é essencial, pois a falta de controle pode levar a diversas complicações e riscos à saúde do paciente.
Mining for Gems: Early Detection of Calcinosis in Juvenile Dermatomyositis Using Low-Dose Computed Tomography
Authors: Vyzhga Yulia , Doria Andrea S. , Feldman Brian M. , Tse Shirley M. 
Published: September 2024

Calcinosis, a common complication in juvenile dermatomyositis (JDM), affects up to 40% of patients and can be associated with uncontrolled disease activity and morbidity.1A 9-year-old female with a 17-month history of JDM presented with worsened bilateral knee pain.
Disrupting and restorying horror tropes through fan engagements with the interactive video game Until Dawn
Authors: Jones Karis , Kruidenier Sahara 
Published: September 2024

Until Dawn is a popular horror video game critiqued for its perpetuation of pervasive horror stereotypes around gender, race, and mental illness. Drawing from methods of multisited affinity space ethnography, we followed a group of cosplayers as they live streamed Until Dawn together before cosplaying characters from the franchise at New York Comic Con. Tracing uptake across fans' live streaming interactions and cosplaying encounters as well as across digital texts like social media posts and fan fiction in the wider fandom, we explore the extent to which fans collectively disrupt or restory problematic elements from the video game. We found extensive engagement with gender and mental illness across communities, contexts, and modalities, with some critique of Indigenous appropriation. This analysis reveals both cohesive trajectories of uptake around communal restorying with respect to certain problematic aspects of the source text as well as complex and varied possibilities for critical interpretation across fan work modalities.
Reclaiming Narratives - Muslim Women Navigating Activism in Educational Research Implications and Recommendations for Educators
Authors: Zafar Zainab , Startup Aurra 
Published: September 2024

This chapter delves into the intricate dynamics of activism within educational research within the context of resistance and justice within settler-colonial states from Turtle Island and beyond. Drawing inspiration from Eve Tuck's (2010) concept of shifting from damage-centered research to desire-based research and Sara Ahmed's (2010) work on embodying what it means to be a killjoy, we endeavour to confront and address prevailing tensions we face as visibly identified Muslim women researchers and educators. We position ourselves to navigate the complexities of our lived experiences and advocate for justice in the current climate. We come together from Pakistani and Palestinian familial lineages to share our lived experiences and specific testimonies of ‘othering’ in educational research and activism. Using an anti-colonial and desire-based framework, we explore the framing and tensions of Orientalism and the struggle against it. We also contemplate our identities, positionalities and stances within educational research. Drawing strength from Indigenous cultures and Islamic philosophies, we seek to advocate for disruption, refusal and subversion, essential to activist research. We conclude with implications for educators, universities, researchers, schools, communities, and beyond. We aim to illuminate the paths we navigate as activist researchers, harnessing our collective experiences and reframing the research approach through a desire-based approach.