bluuebunny/crossref_metadata_2025_split huggingface dataset:
To CBE or not to CBE: The Washington state experience
Authors: Cummins Richard W. , Floten B. Jean 
Published: November 2016

BackgroundIn July 2012, the 34 presidents, three chancellors, and State Board leaders for the community and technical colleges of Washington State created a Strategic Visioning Committee. The committee's first project was to identify ways to achieve higher educational attainment rates in the context of the Great Recession with a substantially reduced investment in higher education. The group focused on educational delivery changes that would result in a high‐quality education that is more affordable by utilizing technology.MethodsThe approach the committee pursued was competency‐based education, modeled after Western Governors University. This study examines a critical question within this context: “Can a sustainable, low‐cost CBE program be built from scratch inside or across institutions that have not had grassroots faculty activity for building one?”ResultsThe result was the first, statewide, competency‐Based, online, degree (a direct transfer associate's degree in business), developed, funded, and delivered collaboratively by six colleges and the State Board for Community and Technical Colleges.ConclusionThe article describes the organizational factors and challenges that the collaborating colleges experienced in reaction to the introduction and implementation of the jointly developed CBE degree.
Protein Surface Mimetics: Understanding How Ruthenium Tris(Bipyridines) Interact with Proteins
Authors: Hewitt Sarah H. , Filby Maria H. , Hayes Ed , Kuhn Lars T. , Kalverda Arnout P. , Webb Michael E. , Wilson Andrew J. 
Published: November 2016

AbstractProtein surface mimetics achieve high‐affinity binding by exploiting a scaffold to project binding groups over a large area of solvent‐exposed protein surface to make multiple cooperative noncovalent interactions. Such recognition is a prerequisite for competitive/orthosteric inhibition of protein–protein interactions (PPIs). This paper describes biophysical and structural studies on ruthenium(II) tris(bipyridine) surface mimetics that recognize cytochrome (cyt) c and inhibit the cyt c/cyt c peroxidase (CCP) PPI. Binding is electrostatically driven, with enhanced affinity achieved through enthalpic contributions thought to arise from the ability of the surface mimetics to make a greater number of noncovalent interactions than CCP with surface‐exposed basic residues on cyt c. High‐field natural abundance 1H,15N HSQC NMR experiments are consistent with surface mimetics binding to cyt c in similar manner to CCP. This provides a framework for understanding recognition of proteins by supramolecular receptors and informing the design of ligands superior to the protein partners upon which they are inspired.
ChemInform Abstract: Crystal Structure and Physical Properties of New Ca2TGe3 (T: Pd and Pt) Germanides.
Authors: Klimczuk T. , Xie Weiwei , Winiarski M.j. , Koziol R. , Litzbarski L.s. , Luo Huixia , Cava R.j. 
Published: November 2016

AbstractCa2PdGe3 and Ca2PtGe3 are prepared by arc melting of stoichiometric amounts of Pd or Pt with Ge and subsequent addition of excess Ca (Al2O3 crucible in quartz ampoule, 880 °C, 12 h, ≈50 kPa Ar).
ChemInform Abstract: The Role of Nonmagnetic d0 vs. d10 B‐Type Cations on the Magnetic Exchange Interactions in Osmium Double Perovskites.
Authors: Feng Hai L. , Yamaura Kazunari , Tjeng Liu Hao , Jansen Martin 
Published: November 2016

AbstractPolycrystalline samples of Ba2MOsO6 (M: Sc (I), In (II)) are prepared by solid state reactions of 4:1:2 molar mixtures of BaO2M2O3, and OsO2 (Al2O3 crucibles in quartz ampoules, 950—1025 °C, 96 h).
ChemInform Abstract: Copper‐Catalyzed Perfluoroalkylthiolation of Alkynes with Perfluoroalkanesulfenamides.
Authors: Tlili Anis , Alazet Sebastien , Glenadel Quentin , Billard Thierry 
Published: November 2016

AbstractThe direct perfluoroalkylthiolation of terminal alkynes is readily achieved with sulfenamide reagents of type (II) and (IV) in the presence of Cu(I)‐catalyst.
ChemInform Abstract: Iridium(III)‐Catalyzed Regioselective Direct Arylation of sp2 C—H Bonds with Diaryliodonium Salts.
Authors: Gao Pan , Liu Li , Shi Zhuangzhi , Yuan Yu 
Published: November 2016

AbstractA direct ortho‐arylation of arenes and olefins by diaryliodonium salts yields biaryls and aryl alkenes, resp., under mild reaction conditions and with a high tolerance of functional groups including halides.
ChemInform Abstract: Catalytic Access to Alkyl Bromides, Chlorides and Iodides via Visible Light‐Promoted Decarboxylative Halogenation.
Authors: Candish Lisa , Standley Eric A. , Gomez‐Suarez Adrian , Mukherjee Satobhisha , Glorius Frank 
Published: November 2016

AbstractThe title reaction is achieved in the presence of a typical iridium photocatalyst and various substrates are tolerable.
ChemInform Abstract: Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol.
Authors: Hayashi Yujiro , Nakamura Daichi , Yasui Yusuke , Iwasaki Kotaro , Chiba Hiroaki 
Published: November 2016

Abstractγ,γ‐Dichloro‐β‐hydroxy aldehydes are generated in the first step.
ChemInform Abstract: Chiral Allenes via Alkynylogous Mukaiyama Aldol Reaction.
Authors: Tap Aurelien , Blond Aurelie , Wakchaure Vijay N. , List Benjamin 
Published: November 2016

AbstractThe reaction between aryl aldehydes and diverse alkynyl‐substituted ketene acetals in the presence of a newly designed chiral disulfonimide is examined which provides tetrasubstituted allenes in high yields and with excellent regio‐, diastereo‐, and enantioselectivities.
ChemInform Abstract: Rhodium‐Catalyzed ortho‐Amidations in the Preparation of Thiadiazine 1‐Oxides.
Authors: Cheng Ying , Dong Wanrong , Wang Han , Bolm Carsten 
Published: November 2016

AbstractRhodium‐catalyzed ortho‐amidations of sulfoximines lead to key intermediates for the preparation of thiadiazine 1‐oxides.
ChemInform Abstract: Cationic Palladium(II)‐Catalyzed Dehydrative Nucleophilic Substitutions of Benzhydryl Alcohols with Electron‐Deficient Benzenethiols in Water.
Authors: Hikawa Hidemasa , Machino Yumo , Toyomoto Mariko , Kikkawa Shoko , Azumaya Isao 
Published: November 2016

AbstractA nucleophilic substitution reaction of benzhydryl alcohols with electron‐deficient benzenethiols in water yields the corresponding benzylic thioethers in moderate to excellent yields via an atom economical and environmentally benign protocol.
ChemInform Abstract: The Reactivity of Difluorocarbene with Hydroxylamines: Synthesis of Carbamoyl Fluorides.
Authors: Baars Hannah , Engel Julien , Mertens Lucas , Meister Daniela , Bolm Carsten 
Published: November 2016

AbstractThe conditions for the preparation of title compounds, formed as by‐products during synthetic studies, are optimized.
ChemInform Abstract: Gold‐Catalyzed Facile Access to Indene Scaffolds via Sequential C—H Functionalization and 5‐endo‐dig Carbocyclization.
Authors: Ma Ben , Wu Ziang , Huang Ben , Liu Lu , Zhang Junliang 
Published: November 2016

AbstractA novel and efficient gold‐catalyzed cascade C—H functionalization/5‐endo‐dig cyclization of o‐alkynylaryl α‐diazoesters with electron‐rich aromatic compounds is established.
ChemInform Abstract: Unexpected Formation of π‐Expanded Isoquinoline from Anthracene Possessing Four Electron‐Donating Groups via the Duff Reaction.
Authors: Weclawski Marek K. , Deperasinska Irena , Leniak Arkadiusz , Banasiewicz Marzena , Kozankiewicz Boleslaw , Gryko Daniel T. 
Published: November 2016

AbstractUnder Duff conditions, the reaction of 1,5,9,10‐tetramethoxyanthracene with hexamethylenetetramine yields a 2‐azabenzoanthrone by double electrophilic aromatic substitution, followed by oxidation of the resulting intermediate to form a pyridine ring.
ChemInform Abstract: Multicomponent Strategy for the Preparation of Pyrrolo[1,2‐a]pyrimidine Derivatives under Catalyst‐Free and Microwave Irradiation Conditions.
Authors: Xun Zhan , Feng Xian , Wang Jianjun , Shi Daqing , Huang Zhibin 
Published: November 2016

AbstractThe introduced protocol has the advantages of readily available starting materials, short reaction times, and good regioselectivity.
ChemInform Abstract: The Pauson—Khand Reaction Using Alkynylboronic Esters: Solving a Long‐Standing Regioselectivity Issue.
Authors: Leon Thierry , Fernandez Elena 
Published: November 2016

AbstractFor the first time, an intermolecular Pauson—Khand reaction between norbornadiene and internal alkynylboronic esters allows the installation of the boronic ester moiety at the β‐position of the resulting cyclopentenone with total regio‐ and stereoselectivity.
ChemInform Abstract: Two New Diterpene Alkaloids from the South China Sea Sponge Agelas aff. nemoechinata.
Authors: Li Tao , Wang Bin , de Voogd Nicole J. , Tang Xu‐Li , Wang Qi , Chu Mei‐Jun , Li Ping‐Lin , Li Guo‐Qiang 
Published: November 2016

AbstractNemoechines F (I) and G (II) do not exhibit antimicrobial activities against S.
ChemInform Abstract: A Novel Anticancer Theranostic Pro‐Prodrug Based on Hypoxia and Photo Sequential Control.
Authors: Wang Shuxiang , et al.  
Published: November 2016

AbstractBy modifying the active chemotherapeutic gemcitabine with an o‐hydroxy cinnamic ester derivative locked by a hypoxic trigger p‐nitrobenzyl group, an effective anticancer prodrug (I) with both functions for diagnosis and therapy is successfully developed.
Practical method for correcting heterochromatic stray light in dual‐channel spectrographs for colorimetry
Authors: Imura Kenji , Yamamoto Yuzuru , Takebe Yohsuke , Nagai Yoshiroh 
Published: November 2016

AbstractMeasurements by spectrophotometers more or less suffer from heterochromatic stray light generated in their spectrometers. It is divided into near‐band and off‐band stray lights. While the former appears near the spectral band of the incident flux, the latter distributes broadly across the whole range and is far more problematic from colorimetric point of view. This article presents a practical method for correcting off‐band stray light in dual‐channel array spectrographs often built in modern spectrophotometers. Unlike most correction methods using a line spread function, the presented method estimates the distribution of off‐band stray light across the array as the product of a device‐specific stray light distribution and a total stray light intensity. The latter depends on both the spectral power distribution of an incident flux and a device‐specific rate of change from the incident flux to the off‐band stray light. For further simplification, the method replaces wavelengths by several bands dividing the visible range owing to the moderate spectral dependence of the above rate of change. With those simplifications, the method is practical, effective, and robust enough to work in an inexpensive hand‐held spectrophotometer with the compact spectrograph which often suffers from off‐band stray light. The performance of the method was evaluated with two dual‐channel array spectrographs with and without 2nd‐order‐rejection filter. Specimen lights incident through ten different glass filters were measured and the errors caused by off‐band stray light in the pixel outputs from the array were successfully corrected by the method. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 431–439, 2017
High‐Temperature Hydrogen Storage of Multiple Molecules: Theoretical Insights from Metalated Catechols
Authors: Tsivion Ehud , Veccham Srimukh Prasad , Head‐Gordon Martin 
Published: November 2016

AbstractInsertion of open metal sites (OMS) into metal–organic frameworks (MOFs) is a promising strategy for preparation of physical adsorbents that enable H2 storage at room temperature. Density functional theory (DFT) calculations are reported on a promising paradigm for adsorption of multiple hydrogen molecules to a single OMS attached to an MOF linker via a catechol or thiocatechol. The interactions between adsorbed H2 and the OMS are characterized with special attention to their degrees of freedom and thermal properties. By combining the present calculations with experimental data, some of these materials are predicted to have usable capacities close to the Department of Energy (DOE) 2020 target of 40 gr L−1 marking them as important synthetic targets. Surprisingly, calculations suggest that a Ca–catechol OMS retains the ability to bind up to two hydrogens even in the presence of residual solvent.
High Yield Production of Natural Phenolic Alcohols from Woody Biomass Using a Nickel‐Based Catalyst
Authors: Chen Jiazhi , Lu Fang , Si Xiaoqin , Nie Xin , Chen Junsheng , Lu Rui , Xu Jie 
Published: November 2016

AbstractEfficient depolymerization of woody biomass to produce natural phenolic alcohols not only preserves the original structure of lignin, but also makes the depolymerization process atom‐efficient. Here, high yield production of natural phenolic alcohols (38.7 wt %) from woody biomass has been achieved using a Ni/C catalyst in a methanol–water co‐solvent. The Ni‐based catalyst can efficiently etherify the Cα−OH group in lignin β‐O‐4 motifs under hydrogen atmosphere, which can break the hydrogen bond between the Cβ−O oxygen and the Cα−OH proton to facilitate the Cβ−O cleavage. It was reported that water can also accelerate the etherification of raw lignin with methanol through in situ formation of acid. Our results suggest that breaking the intramolecular hydrogen bonds can accelerate the Cβ−O cleavage, keeping the original structure of lignin unchanged. This work highlights the significance of structure modification in lignin depolymerization and displays a clear potential for the valorization of whole biomass.
Impaired Immunosuppressive Effect of Bronchoalveolar Mesenchymal Stem Cells in Hypersensitivity Pneumonitis: Preliminary Findings
Authors: Balogh Enikő , Nagy Béla , Gyetvai Ágnes , Bene Zsolt , Hendrik Zoltán , Jeney Viktória , Nagy Péter , Papp Ágnes , Balla József , Balla György , Kappelmayer János , Nagy Béla 
Published: November 2016

BackgroundBronchoalveolar mesenchymal stem cells (MSCs) play an important role in the maintenance of lung integrity. Therapeutic application of bone marrow‐derived MSCs reduced chronic bronchial inflammation in idiopathic pulmonary fibrosis, and improved the ratio of survivors in sepsis with pneumonia. This study investigated the effect of MSCs from bronchoalveolar lavage fluid (BALF) of hypersensitivity pneumonitis (HP) on T‐cell function under in vitro conditions.MethodsBronchoalveolar MSCs were obtained via bronchoscopy with BAL from children with severe subacute HP. As control, BALF MSCs were assessed from children without any inflammatory lung disease. Isolated MSCs were characterized via immunophenotyping by flow cytometry and confocal laser scanning microscopy. HP‐derived and healthy separated peripheral blood mononuclear cells (PBMCs) were stimulated by 5 µg/mL phytohemagglutinin in the presence of HP‐derived or control MSCs in 5‐day cultures. Proliferation and activation of T‐cells were characterized by the mean fluorescence intensity (MFI) of 5,6‐carboxyfluorescein‐diacetat succinimidyl ester (CFSE) and CD25, CD69 as well as HLA‐DR surface positivities, respectively.ResultsHP‐derived MSCs showed significantly lower level of CD73, CD90, and CD105 expression compared to control MSCs in both flow cytometric and confocal microscopic experiments. MSCs from HP did not reduce T‐cell proliferation based on CFSE MFI values, while the level of CD25 expression on both control and HP‐derived CD4+ and CD8+ T‐cells was significantly reduced by normal MSCs, while HP‐derived MSCs did not have any significant effect. The level of other activation markers was not markedly modulated by MSCs.ConclusionsBALF MSCs from HP are unable to downregulate the proliferation and activation of T‐cells that may support the development of recurrent intrapulmonary inflammation in HP. © 2016 International Clinical Cytometry Society
A Method for High‐Throughput Deduplication for Primary File Server by Using Prefetch Cache
Authors: KAMEI HITOSHI , NAKAMURA TAKAKI 
Published: November 2016

SUMMARYWe propose a method of high‐throughput file‐level deduplication for primary file servers, called partial data background prefetch (PDBP). To achieve high throughput of deduplication, the method reduces the number of disk I/Os issued during deduplication process. Before running deduplication process, the proposed method prefetches a part of data of shred files referred by deduplicated files. After that, the method processes the files that are larger than a file‐size threshold defined by administrators.In this paper, we evaluate a deduplication processing time by using a simulation model of PDBP. Consequently, we confirm that the processing time of PDBP is reduced by about 50% compared to a conventional file deduplication method when the threshold is set to 4 KB.
Proposal of Chance Index in Co‐occurrence Network
Authors: TAKAYAMA YUKIHIRO , SAGA RYOSUKE 
Published: November 2016

SUMMARYThis paper proposes chance index that estimates whether a node is chance in a co‐occurrence network. Recently, chance discovery researches are attractive for several domains. By using chance discovery, we can develop new business or predict earthquake. However, there is a problem that chance discovery requires analysts’ inference from visualized network so that success and failure of chance discovery depend on analysists. In order to solve this problem, we analyzed the features from previous chance discovery researches and build the two hypotheses: (1) chance nodes have high betweenness centrality and (2) chance nodes connect to others with weak links. Based on the hypotheses, chance index is formulated by two terms about betweenness centrality and the strength of links. We confirm the usability of chance index from verification experiments, using Bush network, questionnaire network, interview network, and editorial network.
Chemical activity–based environmental risk analysis of the plasticizer di-ethylhexyl phthalate and its main metabolite mono-ethylhexyl phthalate
Authors: Gobas Frank A.P.C. , Otton S.Victoria , Tupper-Ring Laura F. , Crawford Meara A. , Clark Kathryn E. , Ikonomou Michael G. 
Published: November 2016

Abstract

The present study applies a chemical activity–based approach to: 1) evaluate environmental concentrations of di-ethylhexyl phthalate (DEHP; n = 23 651) and its metabolite mono-ethylhexyl phthalate (MEHP; n = 1232) in 16 environmental media from 1174 studies in the United States, Canada, Europe, and Asia, and in vivo toxicity data from 934 studies in 20 species, as well as in vitro biological activity data from the US Environmental Protection Agency's Toxicity Forecaster and other sources; and 2) conduct a comprehensive environmental risk analysis. The results show that the mean chemical activities of DEHP and MEHP in abiotic environmental samples from locations around the globe are 0.001 and 10−8, respectively. This indicates that DEHP has reached on average 0.1% of saturation in the abiotic environment. The mean chemical activity of DEHP in biological samples is on average 100-fold lower than that in abiotic samples, likely because of biotransformation of DEHP in biota. Biological responses in both in vivo and in vitro tests occur at chemical activities between 0.01 to 1 for DEHP and between approximately 10−6 and 10−2 for MEHP, suggesting a greater potency of MEHP compared with DEHP. Chemical activities of both DEHP and MEHP in biota samples were less than those causing biological responses in the in vitro bioassays, without exception. A small fraction of chemical activities of DEHP in abiotic environmental samples (i.e., 4–8%) and none (0%) for MEHP were within the range of chemical activities associated with observed toxicological responses in the in vivo tests. The present study illustrates the chemical activity approach for conducting risk analyses. Environ Toxicol Chem 2017;36:1483–1492. © 2016 SETAC
Quantifying the effects of photoreactive dissolved organic matter on methylmercury photodemethylation rates in freshwaters
Authors: Klapstein Sara J. , Ziegler Susan E. , Risk David A. , O'Driscoll Nelson J. 
Published: November 2016

Abstract

The present study examined potential effects of seasonal variations in photoreactive dissolved organic matter (DOM) on methylmercury (MeHg) photodemethylation rates in freshwaters. A series of controlled experiments was carried out using natural and photochemically preconditioned DOM in water collected from 1 lake in June, August, and October. Natural DOM concentrations doubled between June and August (10.2–21.2 mg C L−1) and then remained stable into October (19.4 mg C L−1). Correspondingly, MeHg concentrations peaked in August (0.42 ng L−1), along with absorbances at 350 nm and 254 nm. Up to 70% of MeHg was photodemethylated in the short 48-h irradiation experiments, with June having significantly higher rates than the other sampling months (p &lt; 0.001). Photodemethylation rate constants were not affected by photoreactive DOM, nor were they affected by initial MeHg concentrations (p &gt; 0.10). However, MeHg photodemethylation efficiencies (quantified in moles MeHg lost/moles photon absorbed) were higher in treatments with less photoreactive DOM. Congruently, MeHg photodemethylation efficiencies also decreased over summer by up to 10 times across treatments in association with increased photoreactive DOM, and were negatively correlated with DOM concentration. These results suggest that an important driver of MeHg photodemethylation is the interplay between MeHg and DOM, with greater potential for photodemethylation in freshwaters with more photobleached DOM and lower DOM content. Environ Toxicol Chem 2017;36:1493–1502. © 2016 SETAC
Microstructural changes of brain in patients with aromatic L‐amino acid decarboxylase deficiency
Authors: Lee Wang‐Tso , Lin Jui‐Hsiang , Weng Wen‐Chin , Peng Steven Shinn‐Forng 
Published: November 2016

AbstractAromatic L‐amino acid decarboxylase (AADC) deficiency is an uncommon inherited neurometabolic disease. The clinical presentations and MR findings in children with AADC deficiency were investigated. Total 12 children (6 boys, 6 girls), aged from 9 to 50 months (mean, 23 ±13 months), with AADC deficiency, were enrolled for analysis. Of 12 patients enrolled, clinical presentations included global developmental delay with generalized hypotonia in 12 (100%), dystonia in 12 (100%), oculogyric crisis in 12 (100%), and excessive sweating in 8 (67%). Sleep problem was also found in 4 (33%). Of 15 MR examinations, the major changes included 6 (40%) with diffusely prominent bilateral frontal sulci, 10 (67%) with prominent frontal horns, and 12 (80%) with hypomyelination. In AADC patients, the frontal horn was significantly widened (P < 0.01), and the volume of caudate nucleus was also significantly smaller than that of controls (P = 0.02). The ratios of thickness of the splenium to that of the genu of corpus callosum were also significantly increased (P < 0.01). There was also significant decrease of fiber density indices in major white matter fiber tracts. Using Tract‐Based Spatial Statistics approach, we also revealed significant change in major fiber tracts related to language function and motor function. In conclusion, the present study indicated that AADC deficiency may have significant impact on brain development, especially the frontal lobe and fiber tracts related to language function and motor function. Long‐term follow‐up of brain MRI in patients with AADC deficiency may clarify the possible effect of AADC deficiency on brain development. Hum Brain Mapp 38:1532–1540, 2017. © 2016 Wiley Periodicals, Inc.