bluuebunny/crossref_metadata_2025_split huggingface dataset:
White matter variations in congenital adrenal hyperplasia: possible implications for glucocorticoid treatment
Authors: Luders Eileen , Spencer Debra , Gaser Christian , Thankamony Ajay , Hughes Ieuan A , Srirangalingam Umasuthan , Gleeson Helena , Kung Karson T F , Cabeen Ryan P , Hines Melissa , Kurth Florian 
Published: September 2024

Abstract
Congenital adrenal hyperplasia has been reported to manifest with white matter aberrations. However, many previous studies included only small samples, restricted their analyses to females, lacked a control group and/or did not correct for brain size. Here, we examined the largest sample to date, comprising 53 male and female participants with congenital adrenal hyperplasia, who were matched with 53 male and female controls in terms of sex, age, education, and verbal intelligence. The four groups were compared with respect to their total white matter as well as white matter hyperintensities while applying brain size corrections. For both measures, total white matter and white matter hyperintensities, there were no significant sex differences or group-by-sex interactions. However, individuals with congenital adrenal hyperplasia had significantly smaller total white matter volumes compared to controls. Our findings align with previous reports of white matter variations in congenital adrenal hyperplasia. The absence of a group-by-sex interaction suggests that white matter variations in congenital adrenal hyperplasia may not be attributable to prenatal androgens. Instead, they may be a result of the condition itself and/or its treatment with glucocorticoids. The latter aspect warrants follow-up, particularly given that glucocorticoids are employed not only in congenital adrenal hyperplasia but also in other medical conditions.
Short and Long-term Body Weight Change Following the Switch to or the Addition of Integrase Inhibitors in Persons With Human Immunodeficiency Virus Differs by Sex
Authors: Lahiri Cecile D , Mehta C Christina , Yang Qian , Maramba Tsungirirai , Musonge-Effoe Joffi , Yang Chin-An , Dumond Julie B , Alcaide Maria L , Lake Jordan E , Rubin Leah H , French Audrey L , Cocohoba Jennifer , Kassaye Seble G , Sharma Anjali , Palella Frank J , Mellors John , Konkle-Parker Deborah , Topper Elizabeth , Augenbraun Michael , Ali Mohammed K , Sheth Anandi N , Ziegler Thomas R , Ofotokun Igho , Alvarez Jessica A 
Published: September 2024

Abstract

Background
Sex-specific, long-term, body weight change in persons with human immunodeficiency virus (PWH) following switch to regimens containing integrase strand transfer inhibitors (INSTIs) is unknown.

Methods
We compared PWH enrolled in the MACS/WIHS Combined Cohort Study (2007–2020) who switched/added an INSTI to their antiretroviral therapy (ART) regimen to those remaining on non-INSTI ART and to people without human immunodeficiency virus (PWOH), by sex. Follow-up time was time since switch visit (or comparable visit in controls). Linear regression mixed-effects models assessed the effects of sex, group, and time upon weight and anthropometric measurements.

Results
Of 3464 participants included, women (411 INSTI, 709 non-INSTI, 818 PWOH) compared to men (223 INSTI, 412 non-INSTI, 891 PWOH) were younger (47.2 vs 54.5 years), were majority non-Hispanic Black (65% vs 23%), and had higher mean body mass index (31.5 vs 26.9 kg/m2), respectively. Women switching to INSTIs experienced greater absolute and percentage weight gain compared to men at 5 years: +3.0 kg (95% confidence interval [CI], 2.1–3.9) versus +1.8 kg (95% CI, .7–2.9) and +4.6% (95% CI, 3.5%–5.7%) versus +2.3% (95% CI, 1.0%–3.6%), respectively ([sex × time × group interaction, P &lt; .01). Compared to men, women switching to INSTIs experienced greater hip and thigh circumference gain at 5 years: +2.6 cm (95% CI, 1.6–3.6) versus +1.2 cm (95% CI, .3–2.1) and +1.5 cm (95% CI, .7–2.2) versus −0.2 cm (95% CI, −.9 to .5), respectively.

Conclusions
Weight change among PWH over 5 years after switch to INSTI was 2-fold higher in women than men. The cardiometabolic implications of this difference in weight gain remain unknown.
Circadian heart rate fluctuations predict cardiovascular and all-cause mortality in type 2 and type 1 diabetes: a 21-year retrospective longitudinal study
Authors: Nesti Lorenzo , Chiriacò Martina , Sacchetta Luca , Moriconi Diego , Santoni Lorenza , Pugliese Nicola Riccardo , Gallo Simone , Cimbalo Noemi , Forotti Giovanna , Chiriacò Giuliano , Leonetti Simone , Natali Andrea , Solini Anna , Tricò Domenico 
Published: September 2024

Abstract

Aims
Circadian heart rate (HR) fluctuations are associated with cardiovascular health. We examined their relationship with microvascular disease and long-term survival in patients with diabetes.

Methods and results
In this secondary analysis from the CHAMP1ON cohort of 497 adults with metabolic disease, 349 participants who had type 1 or type 2 diabetes, baseline 24-h ambulatory blood pressure and HR monitoring (ABPM), and survival data over a 21-year observational follow-up were included. Clinical features, microvascular complications, and mortality rates were examined in participants with low circadian HR fluctuations [24-h HR standard deviation (SD) below the median of 30.4] and blunted nocturnal HR dip (&lt;10%). Low 24-h HR SD and blunted nocturnal HR dip were associated with an adverse cardiometabolic risk profile and 12–23% higher prevalence of cardiac autonomic neuropathy and nephropathy. After 6251 person-year follow-up [21.0 (14.0–21.0) years], a total of 136 (39%) deaths occurred, of which 100 (68%) of cardiovascular cause. The low 24-h HR SD group had a higher risk for both cardiovascular [adjusted hazard ratio (aHR) 2.00, 95% confidence interval (CI) 1.30–3.08, P = 0.002] and all-cause mortality (aHR 1.61, 95% CI 1.13–2.29, P = 0.009), compared with high 24-h HR SD. Similarly, patients with blunted nocturnal HR dip had a higher risk for cardiovascular (aHR 1.63, 95% CI 1.08–2.46, P = 0.019) and all-cause mortality (aHR 1.69, 95% CI 1.20–2.38, P = 0.003), compared with those with preserved nocturnal HR dip.

Conclusion
Impaired circadian HR fluctuations are associated with microvascular disease and long-term cardiovascular and all-cause mortality in diabetes. The ABPM-derived HR measures may provide a widely available and inexpensive risk stratification tool in this high-risk population.
222 Creating a healthy culture through the promotion of physical activity in the university environment
Authors: Pardo-Fernández Alba , Castells Anna , Oliva Irati 
Published: September 2024

Abstract

Purpose
Healthy Campus is a 7-year project to enhance health and lifestyle behaviours of the Tecnocampus community (Pompeu Fabra University). Healthy Campus includes a students’ commission and staff Health Ambassadors. Using the peer methodology in University community improves the level of Physical Activity (PA) habit acquisition and health.

Methods
The strategic plan is evaluated annually using indicators such as activities’ participation and satisfaction. We implement a survey to assess health and lifestyles of the university community.
PA has been promoted mainly through the celebration of World PA Day (DMAF), being the first Catalan university certified in the promotion of bicycles, healthy messages in the building, creation of outdoor Urban health park and sports events. Volunteers students were trained as Health-Agents to co-design and promote different PA actions. PA promotion also has been included in academic curriculum.
In staff, activities of different exercise intensities have been promoted to satisfy different needs and preferences. Workers attend focus groups to detect needs and thus improve interventions in their colleagues.

Results
In the 7 years of the project, 260 actions based on PA promotion has been developed. 165 volunteer students participated in the project and 25 staff health ambassadors participated in Focus-group. A total of 7,373 attended at conferences, courses or workshops. 2200 students participated in World PA Day. 700 staff participate in PA workshops, coursed and activities. 21 academic curricula subjects include PA promotion. This project work together with external entities such as City Council, sports clubs, senior residences, schools, hospitals.

Conclusions
What greatly differentiates this project is the transversality, the peer methodology, the inclusion of PA promotion in academic curriculum and the PA promotion at multiple levels and environments: education, workplace and community level.
The creation of health ambassadors among equals empowers in a very relevant way the objectives of health promotion and PA. In conclusion, it is crucial to train students to be health-conscious citizens who in the future will have the opportunity to promote health in the general population and will influence their lifestyles. And also to create staff ambassadors who spread healthy PA habits.

Support/Funding Source
Without financing
144 Generations Uniting through Movement - Good practices on intergenerational physical activity programs
Authors: Van Holland Berry , Erkoca Hilal , Mombarg Remo 
Published: September 2024

Abstract

The GUM project aimed to use traditional games, movement and sports as one way of promoting intergenerational relations and increased HEPA by setting up an innovative and sustainable GUM program including the creation of a European platform and network on EU Generations Uniting through Movement, a training tool for practitioners and trainers and a GUM app for both youth and elderly.
The concept for the GUM program was to identify, recruit, train and support a cohort of experienced practitioners who will facilitate local-scale collaboration projects between youth and elderly to increase their participation in health-enhancing physical activity and sport. For this purpose the project partners identifyied working principles for those activities (report, factsheet).
These principles served as basis for the development of an online training tool allowing practitioners all over Europe to follow the 7 modules in their own time. The training tool works on multiple aspects: 1) illustrate goals, principles and components of an intergenerational movement and physical activity program, 2) design and deliver a successful GUM program, 3) apply and develop digital literacy as support to GUM offer (using GUM app).
The miMove GUM app allows users to keep track of their activities and communicate with other users and GUM program facilitators. The GUM app has been designed to be used by both elderly and youth allowing them to engage through fun activities. It was also designed to co-create activities by facilitation of GUM program practitioners/trainers. It consists of step-by-step intergenerational movement activity examples selected by the GUM project partners.
GUM project partners have already established a European GUM network, but are also reaching out to partners across Europe and the rest of the world to join the network and exchange knowledge and experience regarding intergenerational HEPA programs.
Several products have been finalized and implemented in practice. Among them are a research report on guiding principles for intergenerational programs, a factsheet for practitioners, a training tool for practitioners and an app for practitioners and end-users. Furthermore, an online platform for the European GUM network has been realized. All these products will help to organize intergenerational HEPA programs.
113 Physical Activity for Health Pilot: Making Physical Activity inclusive for people living with chronic conditions
Authors: Burke Louise 
Published: September 2024

Abstract

Physical Activity for Health (PAFH) is a pilot initiative funded by Sláintecare in collaboration with Sport Ireland where 6 Local Sports Partnerships (LSPs) across the country house a PAFH Officer. Limerick, Longford, Wexford, Wicklow, Waterford and Mayo LSPs were selected for the PAFH pilot and have PAFH officers in post since July 2023.
The LSPs were established in 2001 to help people get active and remove barriers to participation in sport and physical activity. The LSPs aim to create opportunities for all members in the community to be more active with a focus on moving people from inactivity to activity and traditionally focused on people in target groups like women and girls, and people with disabilities. It is now recognised that people living with a chronic condition is a target group that can be reached through the PAFH officer.
The aim of the pilot is to improve pathways for those living with chronic conditions to engage in community based physical activity. The PAFH Officer will bridge the gap that exists for those with a chronic condition who have left the healthcare system and are unable to participate in current LSP programmes. The aim is to ensure that those who need more attention and care will be looked after within these physical activity programmes until they are ready to engage in community based physical activity.
The PAFHOs have engaged with many key stakeholders across the health service, voluntary sector and third level institutions to date and will continue to further expand on this work going forward. The 6 PAFH Officers are in post as of July 2023 and have engaged directly with the public with delivery of programmes by exercise professionals trained to work in this space.
Example of the programmes being delivered include MoveWell: Breathe Well | Limerick Sports Partnership and Walking for Chronic Conditions/Longford Sports Partnership. MoveWell: Activator Walking for Neuro Conditions | Limerick Sports Partnership
The presentation at HEPA will outline the journey to date, lessons learned and the impact of the PAFH pilot on its participants.
217 The Irish Sports Monitor 2011-2023: Data Driven Insights - The Story So Far
Authors: Lacey Eric , Cullen Benny 
Published: September 2024

Abstract

First published in 2007 the Irish Sports Monitor (ISM) is a long-established survey providing an ongoing measurement of sports participation in Ireland. Led by Benny Cullen, director of Research and Innovation at Sport Ireland (SI), the ISM examines both recreational and competitive sport, as defined in the National Sports Policy (2018-2027). The ISM survey’s over 8,000 respondents annually, providing an important monitoring instrument for governmental policy makers while also acting as a critical reference point for many within the academic field of sports and social science in Ireland.
While the study focuses primarily on active sports participation it also provides important insights on club membership, volunteering, event attendance as well as broader physical activity including recreational walking, walking for transport and cycling for transport. More recently Sport Ireland researchers have embarked upon an ambitious data harmonisation journey using input from the ISM and other SI publications, combining over a decade of research datasets into one large ‘data lake’. This new development has enhanced the analytical capability of the organisation allowing for improved cross sectional time series analysis of the datasets. This new approach has helped uncover new insights into how sport and physical activity behaviours change and evolve in a population over time. Sport Ireland have also integrated census data and population projections from Ireland’s central statistics office to the ‘data lake’, which is being used to develop models of the future sport and physical activity behaviours and participation rates in Ireland, out to 2050. The insights from Sport Ireland’s research and the recently developed data lake are being used to assist in the design and development of innovative sport and physical activity programmes, identify and target marginalised communities and inform local and national policy makers on the emergent trends in the Irish sporting landscape. This presentation will demonstrate how a data guided tracking of changes in population dynamics and demographics can help us project and model future levels of sport and physical activity related behaviours. The potential for the development of an integrated multi-national database, built on a harmonised approach to data collection, will also be discussed.
156 ’Cycle-IN’ Student facilitated cycle skills training for children with intellectual and developmental disabilities: An applied case study
Authors: Byrd Erin , McDermott Gary , Taggart Laurence , McMonagle Clare 
Published: September 2024

Abstract

Purpose
In an effort to address the discrepancies in opportunities for children and young people with intellectual and developmental disabilities (IDD) to develop fundamental skills and confidence riding a bicycle, a 12-week collaborative interdisciplinary student-led cycling programme ‘Cycle-IN’ was developed by Ulster University Faculty of Life and Health Sciences and Foyle Down Syndrome Trust.

Methods
Framed within interpretive phenomenology, and drawing upon interviews conducted with the young cyclists, student facilitators, organisation staff and parents, this case study explores the lived experiences of the Cycle-IN programme and evaluates whether the programme is in fact assisting children with IDD (n = 10) to become more confident cyclists, and supporting the professional development of sport and health science student’s (n = 11) competence and confidence to work with children with additional challenges.

Results
Results of this programme demonstrate an overall acceptability of the programme from multiple perspectives. Attendance at sessions was high for both children (M = 83.3% ± 19.7) and student volunteers (84.2% ± 10.0). Mean percentage improvement in cycle skills was 42.6% (±29.4) with mean percentage of basic cycle skills attained 61.6% (±34.3). Qualitative evaluation of the programme identified 1) the challenges and opportunities of the programme, 2) inputs and outputs necessary for sustainable implementation of the programme, and 3) overall recommendations for programme development and scalability into additional contexts, from the perspective of the children, students, organisation staff and parents or caregivers.

Conclusion
This case study presents a novel approach to supporting physical activity and fundamental motor skill development in children with IDD, as well as providing undergraduate students with the opportunity to engage with populations who face additional challenges and barriers to movement. Practice implications are presented in relation to the fidelity of the programme, as well as the sustainability and scalability of such interventions across contexts.

Support/Funding Source
This project was delivered through the Cycle-IN programme at Ulster University and supported by Foyle Down Syndrome Trust.
68 6200-6700 steps per day are associated with better health and wellbeing among working-aged adults a
Authors: Husu Pauliina , Vähä-Ypyä Henri , Tokola Kari , Sievänen Harri , Vasankari Tommi 
Published: September 2024

Abstract

Purpose
Physical activity (PA) is important for health and wellbeing, and the number of steps is one indicator of ambulatory PA. Guidelines of PA needed for health and wellbeing exist, but the adequate number of daily steps is equivocal. This study aimed at identifying potential step cut-points for selected indicators of health and wellbeing.

Methods
The study is based on combined data from two cross-sectional population-based FinFit studies that measured physical behavior, including the daily number of steps, by a triaxial hip-worn accelerometer (UKK RM42) among 20-69-year-old adults. Receiver operator characteristics (ROC) curve analysis was used to analyze potential cut-points for steps in relation to measured waist circumference and blood lipids, as well as perceived health status, and physical and mental quality of life. The optimal cut-point was defined as the point closest to (0,1)-corner in the ROC plane.

Results
Participants (n = 4302, mean age 50.4(SD 13.2) years, 62% women) used the accelerometer for at least 4 days, 24h/day, and took on average 7308 steps per day. The mean waist circumference was 97 cm in males and 88 cm in females. Mean values for total, LDL, and HDL cholesterol and triglycerides were 5.1, 3.1, 1.7, and 1.2 mmol/l, respectively. Most (87%) of the participants perceived their health status as at least good, and 51% reported their physical and mental quality of life to be on at least a median level.
Waist circumference, HDL cholesterol, triglycerides, perceived health status, and both physical and mental quality of life showed a statistically significant (p ≤ 0.001) association with the daily step number. The area under the curve values ranged from 0.53 (mental quality of life) to 0.65 (perceived health). The optimal step cut points ranged from 6123 steps for good perceived health status to 6618 steps for recommended HDL cholesterol.

Conclusions
Working-aged adults should take at least 6200-6700 steps per day to have recommended waist circumference, HDL-cholesterol, and triglycerides, to perceive their health as good, and to have at least a medium level of quality of life.

Funding source
the Finnish Ministry of Education and Culture
220 A Comparative Analysis of Academic and Policymaker Priorities in Physical Activity Policy and Its Infrastructure Support
Authors: Volf Kevin , Connaughton Oisin , Woods Catherine 
Published: September 2024

Abstract

Purpose
Physical activity (PA) researchers regularly seek to impact public policy. However, policymakers may perceive the relevance of policy evidence differently to researchers, thus causing a barrier to research utilization. The Physical Activity Environment Policy Index (PA-EPI) is a 45-indicator policy assessment tool, designed to be used in collaboration with policymakers, to assess both PA policies themselves and also the infrastructure that supports their implementation. This study aimed to identify which of the PA-EPI indicators were rated most important for increasing population levels of PA, and if there was consensus or differences in opinion between academics and policymakers.

Methods
This study is a secondary analysis on data collected from academic experts and policymakers as part of the development of the PA-EPI. Policymakers (n = 40) and academics (n = 50) were asked to rate the importance of each of the 45 PA-EPI indicators on a 10-point Likert scale (1= not at all important to 10 = extremely important for increasing population levels of PA). Differences between the mean importance ratings of policymakers and academics were tested using the Mann Whitney U test.

Results
Mean importance ratings of policymakers and academics were strongly correlated (r = 0.82, p &lt; 0.001 for PA policies themselves and r = 0.77, p = &lt; .001 for policy infrastructure support). Academics rated every indicator higher compared to policymakers, except for the two indicators of the Mass Media subdomain. The indicator receiving the highest level of importance for both policymakers and academics was in the transport domain (Indicator T01). Three indicators were rated significantly different in the domains of Urban Design (indicator UD03; p = 0.027), Funding and Resources (FR03; p = 0.014) and Health in all Policies (HIAP02; p = 0.039).

Conclusion
The findings suggest that policymakers and academics have similar perceptions of the importance of a range of different physical activity policy indicators. These findings present a challenge to theories of research utilization which propose that policymakers and academics are separate, isolated groups with differing views of the evidence supporting different policy propositions.