bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rigid‐body motion correction of the liver in image reconstruction for golden‐angle stack‐of‐stars DCE MRI
Authors: Johansson Adam , Balter James , Cao Yue 
Published: June 2017

PurposeRespiratory motion can affect pharmacokinetic perfusion parameters quantified from liver dynamic contrast‐enhanced MRI. Image registration can be used to align dynamic images after reconstruction. However, intra‐image motion blur remains after alignment and can alter the shape of contrast‐agent uptake curves. We introduce a method to correct for inter‐ and intra‐image motion during image reconstruction.MethodsSixteen liver dynamic contrast‐enhanced MRI examinations of nine subjects were performed using a golden‐angle stack‐of‐stars sequence. For each examination, an image time series with high temporal resolution but severe streak artifacts was reconstructed. Images were aligned using region‐limited rigid image registration within a region of interest covering the liver. The transformations resulting from alignment were used to correct raw data for motion by modulating and rotating acquired lines in k‐space. The corrected data were then reconstructed using view sharing.ResultsPortal‐venous input functions extracted from motion‐corrected images had significantly greater peak signal enhancements (mean increase: 16%, t‐test,P <  0.001) than those from images aligned using image registration after reconstruction. In addition, portal‐venous perfusion maps estimated from motion‐corrected images showed fewer artifacts close to the edge of the liver.ConclusionsMotion‐corrected image reconstruction restores uptake curves distorted by motion. Motion correction also reduces motion artifacts in estimated perfusion parameter maps. Magn Reson Med 79:1345–1353, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Intravesical vanilloids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: A systematic review and meta‐analysis. A report from the Neuro‐Urology Promotion Committee of the International Continence Society (ICS)
Authors: Phé Véronique , Schneider Marc P. , Peyronnet Benoit , Abo Youssef Nadim , Mordasini Livio , Chartier‐Kastler Emmanuel , Bachmann Lucas M. , Kessler Thomas M. 
Published: June 2017

AimsTo systematically assess all available evidence on efficacy and safety of vanilloids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS).MethodsThis systematic review and meta‐analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane register, Embase, Medline, Scopus, (last search January 8, 2016).ResultsAfter screening of 7848 abstracts, 4 randomized controlled trials (RCTs) and 3 prospective cohort studies were included. Pooled data from three RCTs evaluating intravesical capsaicin showed the standardized mean difference to be −2.16 (95% confidence interval [CI] −2.87 to −1.45) in incontinence episodes per 24 h and −0.54 (95%CI −1.03 to −0.05) in voids per 24 h. There was no statistically significant effect on maximum cystometric capacity and maximum storage detrusor pressure. Overall, adverse events were reported by >50% of the patients, most commonly were pelvic pain, facial flush, worsening of incontinence, autonomic dysreflexia, urinary tract infection and haematuria. Risk of bias and confounding was relevant in both RCTs and non‐RCTs.ConclusionsPreliminary data suggest that intravesical vanilloids might be effective for treating NLUTD in patients with MS. However, the safety profile seems unfavorable, the overall quality of evidence is low and no licensed substance is currently available warranting well‐designed, adequately sampled and properly powered RCTs.
Microporous carbon aerogel prepared through ambient pressure drying route as anode material for lithium ion cells
Authors: Alex Ancy Smitha , M.S. Ananda Lekshmi , V. Sekkar , John Bibin , C. Gouri , S.A. Ilangovan 
Published: June 2017

Carbon aerogel synthesized through a cost‐effective and easy method was evaluated and found to be a promising anode material for lithium ion cells. Carbon aerogel was prepared by carbonizing resorcinol–formaldehyde (RF) aerogel under inert atmosphere. Resorcinol–formaldehyde aerogel in turn was prepared through sol gel polymerization of resorcinol with formaldehyde using sodium carbonate as catalyst adopting ambient pressure drying route. The structure and the morphology of the prepared carbon aerogel are investigated using X‐ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and surface area determined using N2–Brunauer–Emmett–Teller (BET) method. The TEM images reveal microporous morphology of the carbon aerogel particles. The evaluation of carbon aerogel as an anode material revealed promising specific capacity synergized with outstanding cyclability. The first cycle specific capacity was 288 mAh/g with an efficiency of 63% at C/10 rate. The material retained a capacity of 96.9% of the initial capacity with about 100% efficiency after 100 cycles, showing the excellent cyclability of the material. Copyright © 2017 John Wiley & Sons, Ltd.
Carbon–sulfur chains: A high‐resolution infrared and quantum‐chemical study of C3S and SC7S
Authors: Dudek John B. , Salomon Thomas , Fanghänel Sven , Thorwirth Sven 
Published: June 2017

AbstractIn the course of a 5 μm high‐resolution infrared study of laser ablation products from carbon–sulfur targets, the ν1 vibrational mode region of linear C3S has been studied continuously from 2046 to 2065 cm−1. Besides the prominent vibrational fundamental, the region was found to feature the
, and even
hot bands, the latter two of which were observed for the first time. Owing to the high signal‐to‐noise ratio obtained, the ν1 mode of
S could also be observed in natural abundance for the first time at high spectral resolution in the infrared. At 2061 cm−1, hidden inside the
branch of the C3S ν1 fundamental mode, a weak new band is observed which exhibits very tight line spacing and stems from a heavy both carbon and sulfur containing carrier. On the basis of high‐level quantum‐chemical calculations of selected carbon–sulfur chains and other carbon‐rich cumulenes, this feature is attributed to the ν5 vibrational fundamental of linear SC7S, which stands for the first gas‐phase spectroscopic detection of this long cumulenic chain.
Accuracy of navigated cam resection in femoroacetabular impingement: A randomised controlled trial
Authors: Van Houcke Jan , Khanduja Vikas , Nakano Naoki , Krekel Peter , Pattyn Christophe , Audenaert Emmanuel 
Published: June 2017

AbstractBackgroundThe main cause for revision hip arthroscopy surgery is incomplete bony resection of femoroacetabular impingement (FAI). This study aimed to compare the cam resection accuracy via the conventional hip arthroscopy technique with the navigation technique.MethodsTwo prospectively randomized groups were recruited: navigated (n = 15) and conventional (n = 14). A pre‐operative CT and post‐operative MRI scan were obtained in all cases to compare alpha angle, range of motion simulation and determine a pre‐operative 3D surgical resection plan.ResultsPost‐operatively, the mean maximal alpha angle improved significantly in the navigated group compared with the conventional group (55°vs.66°; P = 0.023), especially in the 12 o’ clock position (45°vs.60°; P = 0.041). However, positioning time and radiation exposure were significantly longer in the navigated group.ConclusionNavigated surgery is effective for patients with cam type FAI in helping restore normal anatomy, however, not without drawbacks. Larger studies will be required to validate our results.
SISO model‐based control of separated flows: Sliding mode and optimal control approaches
Authors: Feingesicht Maxime , Polyakov Andrey , Kerhervé Franck , Richard Jean‐Pierre 
Published: June 2017

SummaryThe challenging problem of active control of separated flows is tackled in the present paper using model‐based design principles and applied to data issued from a two‐dimensional separated flow experiment. First, a bilinear state and input delay model of the system has been obtained from experimental data by means of a modified identification procedure. Adequacy and precision of the obtained model are demonstrated and compared with existing results. Next, two control problems (setpoint tracking and optimal control) have been formulated and studied using sliding mode control methodology and averaging analysis. The theoretical control results are supported with numerical simulations. Copyright © 2017 John Wiley & Sons, Ltd.
Relationship of prelabor fetal cardiac function with intrapartum fetal compromise and neonatal status at term
Authors: Alsolai A. A. , Bligh L. N. , Greer R. M. , Kumar S. 
Published: June 2017

ABSTRACTObjectivesTo investigate prospectively the relationship of fetal cardiac function and Doppler ultrasound parameters with intrapartum fetal compromise (IFC) in appropriately grown term fetuses. Secondary aims were to correlate prenatal cardiac function with neonatal acid–base status, intrapartum fetal heart rate (FHR) abnormalities and adverse neonatal outcomes.MethodsThis was a blinded, prospective, observational, cohort study of 270 women with an uncomplicated singleton pregnancy who underwent fortnightly ultrasound assessment from 36 weeks' gestation until delivery at the Mater Mother's Hospital, Brisbane, Australia. Fetal cardiac output and blood flow parameters were assessed and correlated with intrapartum and neonatal outcomes. The primary outcome was need for operative (either Cesarean or instrumental vaginal) delivery for IFC. Secondary outcome measures were acidosis at birth, 5‐min Apgar score ≤ 7, suspicious or pathological FHR abnormalities and admission to the neonatal intensive care unit.ResultsTwo hundred and seventy women were included in the analysis, of whom 51 (18.9%) had an emergency operative delivery for IFC. Fetuses that had emergency delivery for IFC showed lower mean left ventricular cardiac output (LVCO) (560 ± 44 mL/min vs 617 ± 73 mL/min; P < 0.001), lower mean LVCO/right ventricular cardiac output (RVCO) ratio (0.55 ± 0.07 vs 0.64 ± 0.11; P < 0.001), lower mean cerebroplacental ratio (CPR) (1.62 ± 0.3 vs 1.90 ± 0.5; P < 0.001) and higher mean RVCO (1026 ± 105 mL/min vs 978 ± 110 mL/min; P = 0.003) compared with those that did not develop IFC. Additionally, LVCO and CPR were lower in fetuses with adverse neonatal outcome.ConclusionTerm fetuses with estimated fetal weight > 10th centile that develop IFC have evidence of lower LVCO and higher RVCO, which are in turn associated with poorer condition of the newborn. Fetal CPR is positively correlated with LVCO. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
A phase Ib study of everolimus combined with metformin for patients with advanced cancer
Authors: Molenaar Remco J. , van de Venne Tim , Weterman Mariëtte J. , Mathot Ron A. , Klümpen Heinz-Josef , Richel Dick J. , Wilmink Johanna W. 
Published: June 2017

SummaryBackground The efficacy to monotherapy with the mTOR inhibitor everolimus in advanced cancer is often limited due to therapy resistance. Combining everolimus with metformin may decrease the chance of therapy resistance. Methods Patients received everolimus and metformin in a 3 + 3 dose-escalation scheme. Objectives were to determine the dose-limiting toxicities (DLTs), maximum tolerated dose, toxic effects, pharmacokinetics and anti-tumour efficacy. Results 9 patients received study treatment for a median duration of 48 days (range: 4–78). 6 patients discontinued due to toxicity and 3 patients because of progressive disease. At the starting dose level of 10 mg everolimus qd and 500 mg metformin bid, 3 out of 5 patients experienced a DLT. After de-escalation to 5 mg everolimus qd and 500 mg metformin bid, considerable toxicity was still observed and patient enrollment was terminated. In pharmacokinetic analyses, metformin was eliminated slower when co-administered with everolimus than as single-agent. After 9 weeks of treatment, 3 patients were still on study and all had stable disease. Conclusion The combination of everolimus and metformin is poorly tolerated in patients with advanced cancer. The pharmacokinetic interaction between everolimus and metformin may have implications for diabetic cancer patients that are treated with these drugs. Our results advocate for future clinical trials with combinations of other mTOR inhibitors and biguanides.
Lipids of the Tail Gland, Body and Muzzle Fur of the Red Fox, Vulpes vulpes
Authors: McLean Stuart , Davies Noel W. , Nichols David S. 
Published: June 2017

AbstractThe tail gland of the red fox (Vulpes vulpes) secretes lipids containing volatile terpenes used in social communication. We have analysed lipids extracted from fur of the tail gland, body (flanks) and muzzle of foxes. GC–MS showed a novel group of iso‐valerate and tiglate monoesters of alkane‐1,2‐diols (C18:0–22:0). There was also a larger group of Type II diesters in which a second, longer chain, fatty acid (FA) was attached to the free alcohol group. LC–MS showed the full range of diol diesters, mostly C36:0–50:0, with smaller amounts of the corresponding mono‐unsaturated tiglate esters. An additional group of diesters with higher MW (C49:0–62:0) containing two long‐chain FA was present in the lipids of body and muzzle fur. After saponification and GC–MS, 98 fatty acids were characterized as their methyl esters. Apart from the C5 FA, most were saturated n‐, iso‐, anteiso‐ or other methyl‐branched FA (C12:0–28:0) whose structures were determined by a combination of their mass spectra and Kovats retention indices. Several FA have not previously been found in nature or in vertebrates. Thirty‐four alkane‐1,2‐diols were found as their TMS derivatives, mostly n‐, iso‐ or anteiso‐isomers of C16:0–25:0. The tail gland had the greatest amount of wax esters, from a greater variety of FA and diols, but lacked the esters with two long‐chain FA. These findings show that fox skin lipids comprise mono‐ and di‐esters of alkane‐1,2‐diols, and exhibit enormous complexity due to the diversity of their constituent FA, diols and the many possible isomers of their esters.
Multivariable adaptive distributed leader-follower flight control for multiple UAVs formation
Authors: Xu Y. , Zhen Z. 
Published: June 2017

ABSTRACTThe Unmanned Aerial Vehicles (UAVs) become more and more popular due to various potential application fields. This paper studies the distributed leader-follower formation flight control problem of multiple UAVs with uncertain parameters for both the leader and followers. This problem has not been addressed in the literature. Most of the existing literature considers the leader-follower formation control strategy with parametric uncertainty for the followers. However, they do not take the leader parametric uncertainty into account. Meanwhile, the distributed control strategy depends on less information interactions and is more likely to avoid information conflict. The dynamic model of the UAVs is established based on the aerodynamic parameters. The establishment of the topology structure between a collection of UAVs is based on the algebraic graph theory. To handle the parametric uncertainty of the UAVs dynamics, a multivariable model reference adaptive control (MRAC) method is addressed to design the control law, which enables follower UAVs to track the leader UAV. The stability of the formation flight control system is proved by the Lyapunov theory. Simulation results show that the proposed distributed adaptive leader-following formation flight control system has stronger robustness and adaptivity than the fixed control system, as well as the existing adaptive control system.
Health Care Student Knowledge and Willingness to Work in Infectious Disease Outbreaks
Authors: Patel Rima , Wattamwar Kapil , Kanduri Jaya , Nahass Meghan , Yoon Jennifer , Oh Justin , Shukla Parth , Lacy Clifton R. 
Published: June 2017

AbstractObjectiveHealth care workers are critical first responders. Understanding which factors motivate their willingness to work (WTW) during infectious disease outbreaks may guide improvements in preparedness. The perspective of health care students, the future workforce, remains largely unexplored. This study compared factors influencing WTW among medical, nursing, and pharmacy students.MethodsA printed survey was administered to 631 medical, nursing, and pharmacy students. The questionnaire elicited information regarding prior disaster training, disease-related knowledge, and WTW in the setting of infectious diseases with contact or respiratory transmission.ResultsAnalyses of the 579 respondents (92% response rate) demonstrated that students were less fearful for their health and more willing to work during outbreaks with contact transmission than during those with respiratory transmission. Medical students were the most fearful for their health, but they demonstrated the greatest WTW, followed by nursing students, and then pharmacy students. Medical students were also the most knowledgeable about infectious diseases. Prior disaster training was associated with greater WTW.ConclusionsExtent of disease-related knowledge and prior disaster training appear to influence WTW. Our findings, taken in the context of a remarkable underemphasis on disaster preparedness in health care curricula, call for a broader incorporation of disaster training to improve the WTW of health care students, and, ultimately, health care workers. (Disaster Med Public Health Preparedness. 2017;11:694–700)
Theory and Metrics of Community Resilience: A Systematic Literature Review Based on Public Health Guidelines
Authors: Zamboni Lucila M. 
Published: June 2017

AbstractA systematic literature review on quantitative methods to assess community resilience was conducted following Institute of Medicine and Patient-Centered Outcomes Research Institute standards. Community resilience is the ability of a community to bounce back or return to normal after a disaster strikes, yet there is no agreement on what this actually means. All studies reviewed addressed natural disasters, but the methodological approaches can be applied to technological disasters, epidemics, and terrorist attacks. Theoretical frameworks consider the association between vulnerability, resilience, and preparedness, yet these associations vary across frameworks. Because of this complexity, indexes based on composite indicators are the predominant methodological tool used to assess community resilience. Indexes identify similar dimensions but observe resilience at both the individual and geographical levels, reflecting a lack of agreement on what constitutes a community. A consistent, cross-disciplinary metric for community resilience would allow for identifying areas to apply short-term versus long-term interventions. A comparable metric for assessing geographic units in multiple levels and dimensions is an opportunity to identify regional strengths and weaknesses, develop timely targeted policy interventions, improve policy evaluation instruments, and grant allocation formulas design. (Disaster Med Public Health Preparedness. 2017;11:756–763)
STRONG COMPLETENESS OF PROVABILITY LOGIC FOR ORDINAL SPACES
Authors: AGUILERA JUAN P. , FERNÁNDEZ-DUQUE DAVID 
Published: June 2017

AbstractGiven a scattered space $\mathfrak{X} = \left( {X,\tau } \right)$ and an ordinal λ, we define a topology $\tau _{ + \lambda } $ in such a way that τ+0 = τ and, when $\mathfrak{X}$ is an ordinal with the initial segment topology, the resulting sequence {τ+λ}λ∈Ord coincides with the family of topologies $\left\{ {\mathcal{I}_\lambda } \right\}_{\lambda \in Ord} $ used by Icard, Joosten, and the second author to provide semantics for polymodal provability logics.We prove that given any scattered space $\mathfrak{X}$ of large-enough rank and any ordinal λ > 0, GL is strongly complete for τ+λ. The special case where $\mathfrak{X} = \omega ^\omega + 1$ and λ = 1 yields a strengthening of a theorem of Abashidze and Blass.
Relationship between solar activity and Δ14C peaks in AD 775, AD 994, and 660 BC
Authors: Park Junghun , Southon John , Fahrni Simon , Creasman Pearce Paul , Mewaldt Richard 
Published: June 2017

ABSTRACTSince the AD 775 and AD 994 Δ14C peak (henceforth M12) was first measured by Miyake et al. (2012, 2013), several possible production mechanisms for these spike have been suggested, but the work of Mekhaldi et al. (2015) shows that a very soft energy spectrum was involved, implying that a strong solar energetic particle (SEP) event (or series of events) was responsible. Here we present Δ14C values from AD 721–820 Sequoiadendron giganteum annual tree-ring samples from Sequoia National Park in California, USA, together with Δ14C in German oak from 650–670 BC. The AD 721–820 measurements confirm that a sharp Δ14C peak exists at AD 775, with a peak height of approximately 15‰ and show that this spike was preceded by several decades of rapidly decreasing Δ14C. A sharp peak is also present at 660 BC, with a peak height of about 10‰, and published data (Reimer et al. 2013) indicate that it too was preceded by a multi-decadal Δ14C decrease, suggesting that solar activity was very strong just prior to both Δ14C peaks and may be causally related. During periods of strong solar activity there is increased probability for coronal mass ejection (CME) events that can subject the Earth’s atmosphere to high fluencies of solar energetic particles (SEPs). Periods of high solar activity (such as one in October–November 2003) can also often include many large, fast CMEs increasing the probability of geomagnetic storms. In this paper we suggest that the combination of large SEP events and elevated geomagnetic activity can lead to enhanced production of 14C and other cosmogenic isotopes by increasing the area of the atmosphere that is irradiated by high solar energetic particles.
Linoleic acid, α-linolenic acid and enterolactone affect lipid oxidation and expression of lipid metabolism and antioxidant-related genes in hepatic tissue of dairy cows
Authors: Fortin Émilie , Blouin Richard , Lapointe Jérôme , Petit Hélène V. , Palin Marie-France 
Published: June 2017

AbstractAlthough beneficial effects have been attributed to PUFA supplementation in high-yielding dairy cows, diets rich in PUFA may also increase oxidative stress in tissues such as the liver. To fully exploit the health benefits of PUFA, we believe that the addition of natural antioxidants could help in preventing oxidative damage. Using an in vitro precision-cut liver slices (PCLS) tissue culture system, we investigated the effects of different linoleic acid (LA, n-6):α-linolenic acid (ALA, n-3) ratios (LA:ALA ratio of 4, LA:ALA ratio of 15 and LA:ALA ratio of 25) in the presence or absence of the antioxidant enterolactone (ENL) on (1) the mRNA abundance of genes with key roles in hepatic lipid metabolism, oxidative stress response and inflammatory processes, (2) oxidative damages to lipids and proteins and (3) superoxide dismutase activity in early-lactating dairy cows. The addition of LA and ALA to PCLS culture media increased oxidative damage to lipids as suggested by higher concentrations of thiobarbituric acid reactive substances and increased the expression of nuclear factor erythroid 2-related factor 2 target genes. The addition of ENL was effective in preventing lipid peroxidation caused by LA and ALA. Transcript abundance of sterol regulatory element-binding transcription factor 1 and its lipogenic target genes acetyl-CoA carboxylase α, fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) was decreased with LA and ALA, whereas ENL decreased FASN and SCD gene expression. Our results show that addition of LA and ALA to PCLS culture media lowers hepatic lipogenic gene expression and increases oxidative damages to lipids. On the other hand, addition of ENL prevents oxidative damages provoked by these PUFA.