bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Hands‐Free Remote Operation System for a Mobile Robot Using EOG and EMG
Authors: GOTO SATORU , YANO OSAMU , MATSUDA YOSHITAKA , SUGI TAKENAO , EGASHIRA NARUTO 
Published: September 2017

SUMMARYIn this research, a hands‐free remote operation system for a mobile robot using electrooculogram (EOG) and electromyogram (EMG) is developed. The EOG and EMG signals are acquired from one set of electrodes on temples and these are separated by bandpass filter. Four control commands of mobile robot motion generated by processed EOG and EMG signals are transmitted to the mobile robot via wireless communication. Experimental results show the effectiveness of the proposed remote operation system.
A Cooperative Control Algorithm for Multiple SVRs Using Correlation of Measurement Data of Distribution Line
Authors: WATANABE MASAHIRO , TAKAHASHI REIJI , MATSUDA KATSUHIRO , SETO TOSHIYUKI 
Published: September 2017

SUMMARYIn this paper, a cooperative control algorithm for multiple step voltage regulator (SVR) using correlation of measurement data of distribution line is proposed. Conventionally, the control time constant of a SVR placed on the feeder end side was set slower than a SVR placed on the substation side. The unnecessary tap movement of SVR was reduced by this setting. In this case, on the condition that “the photovoltaic power generation output of the feeder end fluctuates” and “only SVR of the end side works”, it is a problem that control of SVR becomes slow. By the proposed method, the SVR settled in end side of a feeder can change its tap rapidly only if the SVR settled in sending side of a feeder will not change its tap by using proposed method. The features of the method are followings: (1) to estimate tap change possibility of the sending side SVR using correlation model of both of the SVR, (2) only use local measurement data of the SVRs for tap change control. By the proposed method, unnecessary tap change operation and lag of tap control are reduced without communication networks.
Deadbeat Control with Disturbance Compensation Method and 1 MHz‐PLL for Single Phase Utility Interactive Inverter
Authors: HANASHIMA YUICHI , YOKOYAMA TOMOKI 
Published: September 2017

SUMMARYIn the near future, many distributed power systems will be connected to utility lines in the local area. The demand for control accuracy of utility interactive inverters will likely increase beyond present capabilities. The utility interactive inverter requires FRT capability to compensate for utility voltage fluctuations. A deadbeat control with disturbance compensation and 1 MHz‐PLL control with quasi‐dq transformation were applied to a utility interactive inverter using an FPGA based hardware controller. The FRT characteristics were verified through simulations and experiments, and the superior characteristics of the proposed method were verified.
New Hybrid‐Excited Motor Using Armature Windings as Field Flux Source
Authors: KUSASE SHIN , KURIHARA KAZUMI 
Published: September 2017

SUMMARYIn this paper, a new hybrid‐excited motor is proposed. Its unique feature is that it has no field exciting coil, despite being a type of bypass yoke core (BYC) hybrid‐excited synchronous motor. Based on finite element analysis (FEA), the following facts are clarified. Since the stator coil magnetomotive force (MMF) and claw poles rotate at the same speed and in the same direction, they are motionless relative to each other. Since the claw poles are located at one of its ends near the BYC surface with a gap, it receives immovable magnetization by the stator coil MMF through the BYC; then the claw poles can supply a magnetic field flux via the BYC. This flux via the BYC increases the total torque, because its torque is added the two other torque components: the permanent magnet torque and claw poles reluctance torque. In addition, the magnetic polarity and the amount of the flux of the claw poles can be varied by controlling the armature current phase angle.
Physical pain increases interpersonal trust in females
Authors: Wang C. , Gao J. , Ma Y. , Zhu C. , Dong X‐W. 
Published: September 2017

AbstractBackgroundPeople behave and interact with others differently when experiencing physical pain. Pain has dramatic effects on one's emotional responses, cognitive functions and social interaction. However, little has been known about whether and how physical pain influences interpersonal trust in social interaction. In the present study, we examined the influence of physical pain on trusting behaviour.MethodsA total of 112 healthy participants were recruited and assigned to physical pain condition (induced by Capsaicin) and control condition (with hand cream), respectively. Thirty minutes after pain induction, three decision‐making tasks were conducted to measure behaviours in social interaction, including trust and trustworthiness (trust game), non‐social risk‐taking (risk game) and altruism (dictator game).ResultsResults showed that physical pain increased interpersonal trust among females, but not among males. Pain did not influence non‐social risk‐taking, altruism or trustworthiness, as evaluated by monetary transfers in those tasks. Moreover, the effect of physical pain on interpersonal trust was fully mediated by expectation of monetary profit.ConclusionsThese findings demonstrate an effect of pain on interpersonal trust and suggest a reciprocity mechanism that the effect may be driven by self‐interest rather than altruistic motivation. The pain effect on trust was evident only in females, implying distinct pain coping strategies used by both genders.SignificanceThe present work highlights the social component of pain and extends our understanding of mutual interactions between pain and social cognition.
Preparation of aroma microcapsules with sodium alginate and tetradecylallyldimethylammonium bromide (TADAB) and its potential applications in cosmetics
Authors: Song Jia , Chen Hongling 
Published: September 2017

AbstractThe formation of apple aroma microcapsules was achieved by sodium alginate (SA) and tetradecylallydimethylammonium bromide (TADAB) as shells based on complex coacervation‐emulsion polymerization. Alkyl alcohol polyoxyethylene ether was employed as emulsifier. Pentaerythritol tetraacrylate (PETRA) was used as a crosslinking agent and methyl methacrylate (MMA) was applied as comonomer to copolymerize with TADAB. The aroma microcapsules were characterized by scanning electron microscopy (SEM). Results showed that the aroma microcapsules prepared under optimal conditions were core‐shell structure. The aroma microcapsules were sphere‐like shape with particle size between 20 to 50 μm. FT‐IR analysis results showed that the electrostatic interactions and polymerization occurred assuredly. TG‐DTA study indicated that the thermal stability of the aroma microcapsules crosslinked with MMA shell was improved, and the thermal resistant temperature was up to 110°C. Moreover, the encapsulation efficiency of aroma microcapsules was measured by ultraviolet–visible near‐infrared spectrophotometer. In the surfactant solution, the release of aroma was quick during the first 8 hours, losing ca. 10.8% aroma encapsulated, however, there was no more else aroma dissolving out from the 9th hour. In open conditions, the encapsulation efficiency of the aroma microcapsules kept 66.57% after 48 hours, compared with the encapsulation efficiency going down alone if the microcapsules were milled.
Volatile components as chemical markers of the botanical origin of Corsican honeys
Authors: Yang Yin , Battesti Marie‐José , Costa Jean , Dupuy Nathalie , Paolini Julien 
Published: September 2017

AbstractIn accordance with the national Appellation d'Origine Contrôlée and the European Protected Designation of Origin labels, Corsican honeys can be classified into six ranges (spring, spring maquis, honeydew maquis, chestnut grove, summer maquis and autumn maquis). Toward proposing a new and faster method for performing honey quality assessments, an headspace‐solid phase microextraction (HS‐SPME)/Gas Chromatography (GC)/GC‐Mass Spectrometry (MS) method with multivariate data analysis – principal component analysis (PCA), cluster analysis (CA), partial lest square (PLS) – was developed using 269 Corsican samples, for which the volatile compositions were established a priori. Corsican honeydew and blossom honey could be differentiated by the richness of 3‐furaldehyde in the category of “honeydew maquis”. This approach also allowed identification of chemical markers of the botanical origins of blossom honeys, including 2‐aminoacetophenone, p‐anisaldehyde, 4‐n‐propylanisole, isophorone, and isomers of lilac aldehyde. Therefore, characterization of the volatile fraction of Corsican honeys combined with chemometric analysis may be useful for detecting the nectar contribution of plant species in honeys with complex nectariferous origins.
The more you test, the more you find: The smallest P‐values become increasingly enriched with real findings as more tests are conducted
Authors: Vsevolozhskaya Olga A. , Kuo Chia‐Ling , Ruiz Gabriel , Diatchenko Luda , Zaykin Dmitri V. 
Published: September 2017

ABSTRACTThe increasing accessibility of data to researchers makes it possible to conduct massive amounts of statistical testing. Rather than follow specific scientific hypotheses with statistical analysis, researchers can now test many possible relationships and let statistics generate hypotheses for them. The field of genetic epidemiology is an illustrative case, where testing of candidate genetic variants for association with an outcome has been replaced by agnostic screening of the entire genome. Poor replication rates of candidate gene studies have improved dramatically with the increase in genomic coverage, due to factors such as adoption of better statistical practices and availability of larger sample sizes. Here, we suggest that another important factor behind the improved replicability of genome‐wide scans is an increase in the amount of statistical testing itself. We show that an increase in the number of tested hypotheses increases the proportion of true associations among the variants with the smallest P‐values. We develop statistical theory to quantify how the expected proportion of genuine signals (EPGS) among top hits depends on the number of tests. This enrichment of top hits by real findings holds regardless of whether genome‐wide statistical significance has been reached in a study. Moreover, if we consider only those “failed” studies that produce no statistically significant results, the same enrichment phenomenon takes place: the proportion of true associations among top hits grows with the number of tests. The enrichment occurs even if the true signals are encountered at the logarithmically decreasing rate with the additional testing.
Controlled JAGGED1 delivery induces human embryonic palate mesenchymal cells to form osteoblasts
Authors: Ndong Jean De La Croix , Stephenson Yvonne , Davis Michael E. , García Andrés J. , Goudy Steven 
Published: September 2017

AbstractOsteoblast commitment and differentiation are controlled by multiple growth factors including members of the Notch signaling pathway. JAGGED1 is a cell surface ligand of the Notch pathway that is necessary for murine bone formation. The delivery of JAGGED1 to induce bone formation is complicated by its need to be presented in a bound form to allow for proper Notch receptor signaling. In this study, we investigate whether the sustained release of JAGGED1 stimulates human mesenchymal cells to commit to osteoblast cell fate using polyethylene glycol malemeide (PEG‐MAL) hydrogel delivery system. Our data demonstrated that PEG‐MAL hydrogel constructs are stable in culture for at least three weeks and maintain human mesenchymal cell viability with little cytotoxicity in vitro. JAGGED1 loaded on PEG‐MAL hydrogel (JAGGED1‐PEG‐MAL) showed continuous release from the gel for up to three weeks, with induction of Notch signaling using a CHO cell line with a Notch1 reporter construct, and qPCR gene expression analysis in vitro. Importantly, JAGGED1‐PEG‐MAL hydrogel induced mesenchymal cells towards osteogenic differentiation based on increased Alkaline phosphatase activity and osteoblast genes expression including RUNX2, ALP, COL1, and BSP. These results thus indicated that JAGGED1 delivery in vitro using PEG‐MAL hydrogel induced osteoblast commitment, suggesting that this may be a viable in vivo approach to bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 552–560, 2018.
Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma
Authors: Liu Xiaoping , Ma Weiping , Yan Yanli , Wu Suge 
Published: September 2017

AbstractPrevious study has demonstrated that high mobility group nucleosome‐binding domain 5 (HMGN5) is involved in tumorigenesis and the development of multidrug resistance in several human cancers. However, the role of HMGN5 in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we showed that HMGN5 was significantly upregulated in ESCC cells. Knockdown of HMGN5 significantly inhibited cell growth and induced cell apoptosis of ESCC cells. Moreover, knockdown of HMGN5 increased the sensitivity of ESCC cells towards cisplatin. By contrast, overexpression of HMGN5 showed the opposite effects. Further experiments demonstrated that HMGN5 regulated the expression of multidrug resistance 1, cyclin B1, and Bcl‐2. Overall, our results reveal that HMGN5 promotes tumor progression of ESCC and is also an important regulator of chemoresistance. Our study suggests that inhibition of HMGN5 may be a potential strategy for improving effectiveness of ESCC treatment.
Cloning, expression pattern analysis, and subcellular localization of Capra hircus SCD1 gene with production of transgenic mice
Authors: Zuo Qisheng , Jin Kai , Song Jiuzhou , Zhang Yani , Li Bichun 
Published: September 2017

AbstractThis study aimed to clone the Stearoyl‐CoA desaturase 1 (SCD1) gene derived from Xuhuai goat (Capra hircus), and analyze the sub‐cellular localization in cells and tissues. The cDNA was cloned by reverse transcription polymerase chain reaction (RT‐PCR). pEGFP‐SCD1 vector was constructed to detect sub‐cellular localization and tissue distribution. pEGFP‐SCD1 was transfected into NIH‐3T3 cells using polyethylene imine (PEI) and observed under fluorescence inversion microscope system 48 h after transfection. The expression level of SCD1 was detected by RT‐PCR. Testicular injection was used to produce transgenic mice with goat SCD1 gene. DNA and protein were extracted from the tail tissue of F1 mice. The expression of exogenous gene in the F1 generation was detected in both DNA and protein. The results showed that the coding sequence (CDS) fragments of C. hircus SCD1 gene was 1074 bp and encodes 360 amino acids. RT‐PCR results showed that SCD1 could be expressed successfully in NIH‐3T3 cells in vitro. Sub‐cellular localization analysis showed that pEGFP‐SCD1 fusion protein located in the cytoplasm. It can be concluded that transgenic mice with goat SCD1 expressed in sperm and tail tissue was successfully produced in the F1 mice generation.
MicroRNA‐410 is involved in mitophagy after cardiac ischemia/reperfusion injury by targeting high‐mobility group box 1 protein
Authors: Yang Fan , Li Tong , Dong Zhihuan , Mi Rui 
Published: September 2017

AbstractMitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR‐410, was previously reported to be dynamically regulated in diverse cardiomyopathies, but its mechanism is unclear. In the present study, in a cardiac I/R injury mice model, the expression of miR‐410 was significantly upregulated, accompanied with decreased mitochondrial function and mitophagy deficit. After an unbiased search for downstream messenger RNA targets of miR‐410, effects of the target gene in mitochondrial dysfunction during I/R injury and the underlying mechanism were further explored in cultured human adult cardiac myocytes (HACMs). The results showed that MitoTracker Red‐labeled HACMs mitochondria overlapped with GFP‐LC3‐labeled autophagosomes, suggesting the presence of mitophagy. MiR‐410 expression was significantly increased in hypoxia/reoxygenation (H/R)‐stimulated HACMs. MiR‐410 overexpression further inhibited cell viability, ATP production, mitochondrial membrane potential and mitophagy level, and increased caspase‐3 activity, Bax expression and cytochrome c release. Conversely, inhibition of miR‐410 attenuated these effects. We found that miR‐410 directly interacted with the 3′‐untranslated region of the suppressor of high‐mobility group box 1 protein (HMGB1) by Dual‐Luciferase assay. Moreover, pcDNA3.1‐HMGB1 pretreatment effectively reduced the inhibition effects of cell viability and mitophagy brought by H/R, while all those effects can be attenuated by pretreatment with HSPB1 siRNA transfection. Taken together, our results suggest that miR‐410 may inhibit mitophagy after cardiac I/R injury by modulating HSPB1 activity via directly targeting HMGB1.
Haloperidol Versus 5‐HT3 Receptor Antagonists for Postoperative Vomiting and QTc Prolongation: A Noninferiority Meta‐Analysis and Trial Sequential Analysis of Randomized Controlled Trials
Authors: Singh Preet Mohinder , Borle Anuradha , Makkar Jeetinder Kaur , Trikha Anjan , Fish David , Sinha Ashish 
Published: September 2017

AbstractHaloperidol is an antipsychotic with well‐known antiemetic potential. It is underutilized for postoperative nausea vomiting due to reported corrected QT interval (QTc) prolongation. This meta‐analysis evaluates its safety and efficacy as an antiemetic in the perioperative period. Trials comparing haloperidol to 5‐HT3‐receptor antagonists (5‐HT3‐RA) for 24 postoperative vomiting incidences published up to May 2017 were searched in the medical database. Comparisons were made for antiemetic efficiency variables (vomiting incidence, rescue antiemetic need, and patients with complete response) during early (until 6 hours) and late postoperative phases. Eight randomized controlled double‐blinded trials were included in the final analysis. Twenty‐four‐hour vomiting incidence was similar in groups (fixed effects, P = 0.52, I2 = 0%). Trial‐sequential analysis confirmed noninferiority of haloperidol over 5‐HT3‐RAs (α = 5%, β = 20%, δ = 10%), with “information size” being 859 (required > 812). Pooled results did not demonstrate superiority/inferiority of 5‐HT3‐RAs over haloperidol in all other antiemetic efficacy variables (early and delayed). Negligible heterogeneity was found in all the comparisons made. Pooled Mantel Haenszel odds ratio for QTc prolongation was equivalent in both groups (fixed effects, P = 0.23, I2 = 0%). The mean dose of haloperidol used was 1.34 mg, and no trial reported extrapyramidal side effects. Trial‐sequential analysis showed statistical equivalence (α = 5%, β = 20%, δ = 10%), with information size being 745 (required > 591). Publication bias was unlikely (Egger test, X‐intercept = 2.07, P = 0.10). We conclude that haloperidol is equivalent to the well‐established 5‐HT3‐RAs in preventing vomiting during the first day after surgery. The incidence of QTc prolongation with haloperidol is statistically equivalent to 5‐HT3‐RAs and thus should not be the factor that discourages its use for treatment/prophylaxis of postoperative nausea vomiting.
Burrowing with a kinetic snout in a snake (Elapidae: Aspidelaps scutatus)
Authors: Deufel Alexandra 
Published: September 2017

AbstractOf the few elongate, fossorial vertebrates that have been examined for their burrowing mechanics, all were found to use an akinetic, reinforced skull to push into the soil, powered mostly by trunk muscles. Reinforced skulls were considered essential for head‐first burrowing. In contrast, I found that the skull of the fossorial shield‐nosed cobra (Aspidelaps scutatus) is not reinforced and retains the kinetic potential typical of many non‐fossorial snakes. Aspidelaps scutatus burrows using a greatly enlarged rostral scale that is attached to a kinetic snout that is independently mobile with respect to the rest of the skull. Two mechanisms of burrowing are used: (1) anteriorly directed head thrusts from a loosely bent body that is anchored against the walls of the tunnel by friction, and (2) side‐to‐side shovelling using the head and rostral scale. The premaxilla, to which the rostral scale is attached, lacks any direct muscle attachments. Rostral scale movements are powered by, first, retractions of the palato‐pterygoid bar, mediated by a ligament that connects the anterior end of the palatine to the transverse process of the premaxilla and, second, by contraction of a previously undescribed muscle slip of the m. retractor pterygoidei that inserts on the skin at the edge of the rostral scale. In derived snakes, palatomaxillary movements are highly conserved and power prey capture and transport behaviors. Aspidelaps scutatus has co‐opted those mechanisms for the unrelated function of burrowing without compromising the original feeding functions, showing the potential for evolution of functional innovations in highly conserved systems.
Evaluation of summer precipitation from EURO‐CORDEX fine‐scale RCM simulations over Norway
Authors: Dyrrdal Anita Verpe , Stordal Frode , Lussana Cristian 
Published: September 2017

ABSTRACTRegional climate models represent a valuable tool in climate impact analyses. Their ability to accurately estimate current and future climate conditions is increasingly important. In Norway precipitation is of special interest. Heavy precipitation, particularly over short durations, is responsible for enormous damages to infrastructure such as roads and railways, hence information on a fine spatial and temporal scale is crucial. We evaluate the ability of seven regional climate model simulations of 0.11° resolution from the CORDEX ensemble in reproducing 3‐h and 24‐h accumulated summer precipitation characteristics in Norway. The two‐step evaluation includes comparison of modelled precipitation to gridded observation‐based datasets and to station measurements in terms of the following indices: summer maxima, summer wet event frequency, and total summer precipitation. We find a general overestimation by the models for all indices, with only few exceptions. Country‐wide spatial averages show, however, that simulated summer maxima are mainly within the uncertainty interval of the gridded reference dataset. This might also be true for summer wet event frequency, although the comparison to station measurements indicates that the positive bias is significant. We find the largest deviation between models in the evaluation of summer totals. The spatial distribution of the different precipitation indices is fairly well simulated, although the precipitation gradients evident in observation‐based datasets appear weak in the models. We believe the high spatial resolution improves the simulations of extreme precipitation in Norway, especially in areas of orographic enhancement.
On semi‐isogenous mixed surfaces
Authors: Cancian Nicola , Frapporti Davide 
Published: September 2017

AbstractLet C be a smooth projective curve and G be a finite subgroup of whose action is mixed, i.e. there are elements in G exchanging the two isotrivial fibrations of . Let be the index two subgroup . If G0 acts freely, then is smooth and we call it semi‐isogenous mixed surface. In this paper we give an algorithm to determine semi‐isogenous mixed surfaces with given geometric genus, irregularity and self‐intersection of the canonical class. As an application we classify irregular semi‐isogenous mixed surfaces with and geometric genus equal to the irregularity; the regular case is subjected to some computational restrictions. In this way we construct new examples of surfaces of general type with . We provide an example of a minimal surface of general type with and .