bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dictionary form in decoding, encoding and retention: Further insights
Authors: Dziemianko Anna 
Published: June 2017

AbstractThe aim of the paper is to investigate the role of dictionary form (paper versus electronic) in language reception, production and retention. The body of existing research does not give a clear answer as to which dictionary medium benefits users more. Divergent findings from many studies into the topic might stem from differences in research methodology (including the various tasks, participants and dictionaries used by different authors). Even a series of studies conducted by one researcher (Dziemianko, 2010, 2011, 2012b) leads to contradictory conclusions, possibly because of the use of paper and electronic versions of existing dictionaries, and the resulting problem with isolating dictionary form as a factor. To be able to argue with confidence that the results obtained follow from different dictionary formats, rather than presentation issues, research methodology should be improved. To successfully generalize about the significance of the medium for decoding, encoding and learning, the current study replicates previous research, but the presentation of lexicographic data on paper and on screen is now balanced, and the paper/electronic opposition is operationalized more appropriately. A real online dictionary and its paper-based counterpart composed of printouts of screen displays were used in the experiment in which the meaning of English nouns and phrases was explained, and collocations were completed with missing prepositions. A delayed post-test checked the retention of the meanings and collocations. The results indicate that dictionary medium does not play a statistically significant role in reception and production, but it considerably affects retention.
Theology and Politics in Laudato Si’
Authors: Jamieson Dale 
Published: June 2017

Pope Francis has more epistemological and moral authority than any scientist, philosopher, lawyer, or politician. He has the second most popular twitter feed, and his messages are more likely to be retweeted than anyone else’s. The Pope has the power to order some and to persuade others. Most of all he has the power to affect the global agenda. When the Pope speaks, people listen.Pope Francis commands respect for many reasons. He sits atop a hierarchy with which 1.2 billion people are affiliated. Organized more like a multinational corporation than a nation-state, the Catholic Church and its members are spread across all the countries of the world. But it is not just Catholics who take his pronouncements seriously. As a man of the South, occupying an office in the North, with no national allegiance except to a country of 110 acres with a population of 842, he is uniquely situated to speak out on global issues. Laudato Si’ also commands respect because it is an astonishingly well-written argument for a powerful point of view, one that in various bits and pieces can be found in the small journals and ignored books of environmental philosophy and theology.
Politics, the Rule of Law, and the Role of the Crime of Aggression: A Response to Koh and Buchwald
Authors: Dannenbaum Tom 
Published: June 2017

In this essay, I take up two concerns raised by Harold Koh and Todd Buchwald in their critique of the Kampala amendments on aggression: what they term “proxy prosecution” and the notion of aggression as a uniquely political question. I also take issue with the argument in Alain Pellet’s response on attacks by nonstate actors.These areas of contention notwithstanding, there are important issues on which I think that Koh and Buchwald get it right. In forthcoming work, I argue that the object and purpose of the criminalization of aggression precludes an interpretation of Article 8bisof the Rome Statute that would include humanitarian interventions not authorized by the Security Council. Nonetheless, the failure to make this textually explicit at Kampala was a mistake that the authors are correct to lament. Similarly, they accurately identify the ambiguities in the provisions on the amendments’ entry into force as an entirely avoidable defect that creates unnecessary confusion. These important points notwithstanding, the article takes some misleading positions on the politics of the crime.
Does International Law Really Require the Criminalization of Marital Rape?
Authors: Stark Barbara 
Published: June 2017

Nothing can be said in favor of intimate sexual violence, including marital rape, as Randall and Venkatesh, the authors of Intimate Sexual Violence, Human Rights Obligations and the State, make plain. As the New York Court of Appeals held in 1984:
Rape is not simply a sexual act to which one party does not consent. Rather, it is a degrading, violent act which violates the bodily integrity of the victim and frequently causes severe, long-lasting physical and psychic harm. To ever imply consent to such an act is irrational and absurd. . . . A married woman has the same right to control her body as does an unmarried woman.There is something to be said, however, in favor of clearly setting out a legal position before condemning it, in favor of a conservative approach to the wholesale expansion of human rights, and in favor of enabling women, even women in states that do not criminalize marital rape, to set their own priorities. The authors draw on international law to make a passionate case against marital rape, and against domestic laws that fail to recognize it as a crime. Their argument would be more persuasive if their demand for what domestic law must criminalize were clearer, if their international legal analysis were more rigorous and more focused, and if they justified the top-down approach they recommend here, which seems particularly problematic in this context.
Ubiquity and quantitative significance of bacterioplankton lineages inhabiting the oxygenated hypolimnion of deep freshwater lakes
Authors: Okazaki Yusuke , Fujinaga Shohei , Tanaka Atsushi , Kohzu Ayato , Oyagi Hideo , Nakano Shin-ichi 
Published: June 2017

Abstract
The oxygenated hypolimnion accounts for a volumetrically significant part of the global freshwater systems. Previous studies have proposed the presence of hypolimnion-specific bacterioplankton lineages that are distinct from those inhabiting the epilimnion. To date, however, no consensus exists regarding their ubiquity and abundance, which is necessary to evaluate their ecological importance. The present study investigated the bacterioplankton community in the oxygenated hypolimnia of 10 deep freshwater lakes. Despite the broad geochemical characteristics of the lakes, 16S rRNA gene sequencing demonstrated that the communities in the oxygenated hypolimnia were distinct from those in the epilimnia and identified several predominant lineages inhabiting multiple lakes. Catalyzed reporter deposition fluorescence in situ hybridization revealed that abundant hypolimnion-specific lineages, CL500-11 (Chloroflexi), CL500-3, CL500-37, CL500-15 (Planctomycetes) and Marine Group I (Thaumarchaeota), together accounted for 1.5–32.9% of all bacterioplankton in the hypolimnion of the lakes. Furthermore, an analysis of single-nucleotide variation in the partial 16S rRNA gene sequence (oligotyping) suggested the presence of different sub-populations between lakes and water layers among the lineages occurring in the entire water layer (for example, acI-B1 and acI-A7). Collectively, these results provide the first comprehensive overview of the bacterioplankton community in the oxygenated hypolimnion of deep freshwater lakes.
Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment
Authors: Ries Ariane-Saskia , Hermanns Tim , Poeck Burkhard , Strauss Roland 
Published: June 2017

AbstractMajor depressive disorder (MDD) affects millions of patients; however, the pathophysiology is poorly understood. Rodent models have been developed using chronic mild stress or unavoidable punishment (learned helplessness) to induce features of depression, like general inactivity and anhedonia. Here we report a three-day vibration-stress protocol for Drosophila that reduces voluntary behavioural activity. As in many MDD patients, lithium-chloride treatment can suppress this depression-like state in flies. The behavioural changes correlate with reduced serotonin (5-HT) release at the mushroom body (MB) and can be relieved by feeding the antidepressant 5-hydroxy-L-tryptophan or sucrose, which results in elevated 5-HT levels in the brain. This relief is mediated by 5-HT-1A receptors in the α-/β-lobes of the MB, whereas 5-HT-1B receptors in the γ-lobes control behavioural inactivity. The central role of serotonin in modulating stress responses in flies and mammals indicates evolutionary conserved pathways that can provide targets for treatment and strategies to induce resilience.
The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?
Authors: Sattler Susanne , Fairchild Paul , Watt Fiona M. , Rosenthal Nadia , Harding Sian E. 
Published: June 2017

AbstractThe regenerative capacity of adult human tissues and organs is limited, but recent developments have seen the advent of promising new technologies for regenerative therapy. The human heart is of particular interest for regenerative medicine, as cardiac tissue damage is repaired by the formation of rigid scar tissue, which causes inevitable structural changes and progressive functional decline leading to heart failure. Cardiac regenerative medicine aims to prevent scar formation or replace existing scars to halt or reverse adverse remodeling and therapeutic approaches include the use of biomaterials, gene therapies, delivery of growth factors, and (stem) cell therapies. Regenerative therapies, however, face significant obstacles in a hostile microenvironment. While the early immune response to a myocardial infarct is essential to ensure tissue integrity and to avoid fatal cardiac rupture, excessive activation of endogenous repair mechanisms may lead to ongoing inflammation, fibrosis, and sustained autoimmune-mediated tissue damage. Anti-cardiac autoreactivity of the adaptive immune system has been suggested to be involved in structural remodeling, functional decline, and the development of heart failure. It is, therefore, crucial to first understand the endogenous response to cardiac tissue damage and how to restore immune tolerance to cardiac tissue, before additional regenerative therapies can achieve their full potential.
Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
Authors: Wissing Tamar B. , Bonito Valentina , Bouten Carlijn V. C. , Smits Anthal I. P. M. 
Published: June 2017

AbstractThere is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
Authors: Lu Shi-Yu , Wang Chang-Yuan , Jin Yue , Meng Qiang , Liu Qi , Liu Zhi-hao , Liu Ke-Xin , Sun Hui-Jun , Liu Mo-Zhen 
Published: June 2017

AbstractRecently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic agent for the treatment of GIOP. In this study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. Here, the results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers, including ALP, COL-I, OCN, BMP-2, RUNX2 and OSX. Further study revealed that the osteogenesis-promoting effects of LA likely occur via the regulation of the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. The present study indicated that LA may prevent GIOP and promote osteogenesis and might be a candidate for the treatment of GIOP.
Modification of Different Pulps by Homologous Overexpression Alkali-Tolerant Endoglucanase in Bacillus subtilis Y106
Authors: Wang Meimei , Du Jian , Zhang Daolei , Li Xuezhi , Zhao Jian 
Published: June 2017

AbstractCellulase (mainly endoglucanase, EG) has been used in pulp modification for improving paper quality through environmentally friendly process. But low activity in alkaline pH and high filter paper activity (FPA) were still obstacles for extending the cellulase application in papermaking industry. In the study, an alkali-tolerant EG gene ofBacillus subtilisY106 was homologous over-expressed for obtaining suitable enzyme used in pulp modification. The engineering strain could produce the crude enzyme with more alkali-tolerant EG and little PFA. Potential of the crude enzyme in modification of different pulps were investigated. It was found that the enzyme could be used for improving drainage and strength properties of pulps from softwood, hardwood and non-wood materials, especially non-wood pulp such as wheat straw pulp. The underlying mechanisms of pulp modification and different effects on various types of pulps by the EG treatment were also discussed by studying the change in fibers characteristics and fiber bonding.
Brain size is reduced by selection for tameness in Red Junglefowl– correlated effects in vital organs
Authors: Agnvall Beatrix , Bélteky Johan , Jensen Per 
Published: June 2017

AbstractDuring domestication animals have undergone changes in size of brain and other vital organs. We hypothesize that this could be a correlated effect to increased tameness. Red Junglefowl (ancestors of domestic chickens) were selected for divergent levels of fear of humans for five generations. The parental (P0) and the fifth selected generation (S5) were culled when 48–54 weeks old and the brains were weighed before being divided into telencephalon, cerebellum, mid brain and optic lobes. Each single brain part as well as the liver, spleen, heart and testicles were also weighed. Brains of S5 birds with high fear scores (S5 high) were heavier both in absolute terms and when corrected for body weight. The relative weight of telencephalon (% of brain weight) was significantly higher in S5 high and relative weight of cerebellum was lower. Heart, liver, testes and spleen were all relatively heavier (% of body weight) in S5 high. Hence, selection for tameness has changed the size of the brain and other vital organs in this population and may have driven the domesticated phenotype as a correlated response.
Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
Authors: Smarr Benjamin L. , Grant Azure D. , Perez Luz , Zucker Irving , Kriegsfeld Lance J. 
Published: June 2017

AbstractModern life involves chronic circadian disruption through artificial light and these disruptions are associated with numerous mental and physical health maladies. Because the developing nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian disruption would negatively impact offspring development and adult function. Pregnant mice were subjected to chronic circadian disruption from the time of uterine implantation through weaning. To dissociate in utero from postnatal effects, a subset of litters was cross-fostered at birth from disrupted dams to control dams and vice versa. Postnatal circadian disruption was associated with reduced adult body mass, social avoidance, and hyperactivity. In utero disruption resulted in more pronounced social avoidance and hyperactivity, phenotypes not abrogated by cross-fostering to control mothers. To examine whether circadian disruption affects development by acting as an early life stressor, we examined birthweight, litter size, maternal cannibalism, and epigenetic modifications. None of these variables differed between control and disrupted dams, or resembled patterns seen following early-life stress. Our findings indicate that developmental chronic circadian disruption permanently affects somatic and behavioral development in a stage-of-life-dependent manner, independent of early life stress mechanisms, underscoring the importance of temporal structure during development, both in utero and early postnatal life.
Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach
Authors: Hsu Kai-Cheng , Liu Chang-Yi , Lin Tony Eight , Hsieh Jui-Hua , Sung Tzu-Ying , Tseng Hui-Ju , Yang Jinn-Moon , Huang Wei-Jan 
Published: June 2017

AbstractHistone deacetylases (HDAC) contain eighteen isoforms that can be divided into four classes. Of these isoform enzymes, class IIa (containing HDAC4, 5, 7 and 9) target unique substrates, some of which are client proteins associated with epigenetic control. Class IIa HDACs are reportedly associated with some neuronal disorders, making HDACs therapeutic targets for treating neurodegenerative diseases. Additionally, some reported HDAC inhibitors contain hydroxamate moiety that chelates with zinc ion to become the cofactor of HDAC enzymes. However, the hydroxamate functional group is shown to cause undesirable effects and has poor pharmacokinetic profile. This study used in silico virtual screening methodology to identify several nonhydroxamate compounds, obtained from National Cancer Institute database, which potentially inhibited HDAC4. Comparisons of the enzyme inhibitory activity against a panel of HDAC isoforms revealed these compounds had strong inhibitory activity against class IIa HDACs, but weak inhibitory activity against class I HDACs. Further analysis revealed that a single residue affects the cavity size between class I and class IIa HDACs, thus contributing to the selectivity of HDAC inhibitors discovered in this study. The discovery of these inhibitors presents the possibility of developing new therapeutic treatments that can circumvent the problems seen in traditional hydroxamate-based drugs.
QTL mapping reveals genetic determinants of fungal disease resistance in the wild lentil species Lens ervoides
Authors: Bhadauria Vijai , Ramsay Larissa , Bett Kirstin E. , Banniza Sabine 
Published: June 2017

AbstractLens ervoides, a wild relative of lentil is an important source of allelic diversity for enhancing the genetic resistance of the cultivated species against economically important fungal diseases, such as anthracnose and Stemphylium blight caused by Colletotrichum lentis and Stemphylium botryosum, respectively. To unravel the genetic control underlying resistance to these fungal diseases, a recombinant inbred line (RIL) population (n = 94, F9) originating from a cross between two L. ervoides accessions, L01-827A and IG 72815, was genotyped on the Illumina HiSeq 2500 platform. A total of 289.07 million 100 bp paired-end reads were generated, giving an average 7.53-fold genomic coverage to the RILs and identifying 2,180 high-quality SNPs that assembled in 543 unique haplotypes. Seven linkage groups were resolved among haplotypes, equal to the haploid chromosome number in L. ervoides. The genetic map spanned a cumulative distance of 740.94 cM. Composite interval mapping revealed five QTLs with a significant association with resistance to C. lentis race 0, six QTLs for C. lentis race 1 resistance, and three QTLs for S. botryosum resistance. Taken together, the data obtained in the study reveal that the expression of resistance to fungal diseases in L. ervoides is a result of rearrangement of resistant alleles contributed by both parental accessions.
Development of a selective agonist for relaxin family peptide receptor 3
Authors: Wei Dian , Hu Meng-Jun , Shao Xiao-Xia , Wang Jia-Hui , Nie Wei-Han , Liu Ya-Li , Xu Zeng-Guang , Guo Zhan-Yun 
Published: June 2017

AbstractRelaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1–4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present. A previously designed chimeric R3/I5 peptide, consisting of the B-chain of relaxin-3 and the A-chain of INSL5, displays equal activity towards the homologous RXFP3 and RXFP4. To increase its selectivity towards RXFP3, in the present study we conducted extensive mutagenesis around the B-chain C-terminal region of R3/I5. Decreasing or increasing the peptide length around the B23–B25 position dramatically lowered the activation potency of R3/I5 towards both RXFP3 and RXFP4. Substitution of B23Gly with Ala or Ser converted R3/I5 from an efficient agonist to a strong antagonist for RXFP3, but the mutants retained considerable activation potency towards RXFP4. Substitution of B24Gly increased the selectivity of R3/I5 towards RXFP3 over the homologous RXFP4. The best mutant, [G(B24)S]R3/I5, displayed 20-fold higher activation potency towards RXFP3 than towards RXFP4, meanwhile retained full activation potency at RXFP3. Thus, [G(B24)S]R3/I5 is the best RXFP3-selective agonist known to date. It is a valuable tool for investigating the physiological functions of RXFP3, and also a suitable template for developing RXFP3-specific agonists in future.