bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hausärztliche Versorgung in Deutschland – Gleicher Zugang für alle?
Authors: Bauer Jan , Maier Werner , Müller Ruth , Groneberg David 
Published: September 2017

Zusammenfassung
Hintergrund Ein gleichmäßiger Zugang zu hausärztlicher Versorgung spielt eine wesentliche Rolle bei der medizinischen Versorgung in Deutschland und ist daher Ziel der ambulanten Bedarfsplanung.
Ziel der Arbeit Mit der vorliegenden Arbeit sollen räumliche Aspekte des Zugangs zur hausärztlichen Versorgung untersucht und mit den Zielen der aktuellen Bedarfsplanung verglichen werden.
Material und Methoden Der räumliche Zugang zur hausärztlichen Versorgung wurde auf Basis der „integrated Floating Catchment Area“-Methodik unter Einsatz eines geografischen Informationssystems auf Ebene von Quadratkilometer-Zellen (Hektarzellen für Großstädte) gemessen („Zugangsindex“).
Ergebnisse Die Analyse von 649 Millionen generierten Datensätzen zeigte erhebliche geografische Variationen des Zugangs: 4,7 % der Gesamtbevölkerung leben in Gebieten mit signifikant niedrigerem hausärztlichen Zugang (z-Wert = –3,4) während 48,0 % in einem Gebiet mit signifikant höherem hausärztlichen Zugang leben (z-Wert = 9,7). Der durchschnittliche Zugangsindex lag bei 0,14 (SD = 0,15) und war umso höher, je urbaner das Gebiet (r = 0,64; p < 0,001) und je geringer der Grad der regionalen Deprivation war (r = –0,37; p < 0,001). Innerhalb der Bedarfsplanungsregionen variierte der Zugangsindex um durchschnittlich Δ = 0,23 (SD = 0,19) und korrelierte nicht mit dem hausärztlichen Versorgungsgrad (r = –0,04; p = 0,28).
Diskussion Bezüglich des Zugangs zu hausärztlicher Versorgung bestehen in Deutschland Stadt-Land-Disparitäten sowie soziale Ungleichheit im Sinne regionaler Deprivation. Aus diesem Grund sollte die Bedarfsplanung zukünftig räumliche Aspekte des Zugangs wie Erreichbarkeit und Verfügbarkeit stärker berücksichtigen.
Does Intensive Soccer Playing During the Growth Period Lead to Leg Length Discrepancies?
Authors: Guer Jean-Luc , Blanchard Sylvain , Harnagea Marta , Lopez Eric , Behr Michel 
Published: September 2017

AbstractLeg length discrepancies (LLD) are a common reason for podiatry consultations and can affect up to 90% of the overall population. Furthermore, it is widely recognized that intensive participation in certain sports can alter bone development. The aim of this study is to explore any possible relation between playing soccer and the appearance or evolution of LLD, by means of a retrospective study based on the analysis of case reports of patients followed for foot or plantar troubles. Case reports were selected in the archives of a podiatric clinic for the period between 2002 and 2016 among patients who declared regular to intensive soccer playing, aged 13 years or more. LLD was detected in the vast majority of cases (95 cases out of 104). Pearson correlation coefficients were computed and revealed a strong correlation between the laterality of the kicking limb and that of the shorter leg. The shorter limb was on the side of the kicking leg in 96% of the cases when considering the players who began practice before the age of 13, and only 53% of the cases for others. Intensive soccer playing at a young age may encourage the appearance and evolution of a real LLD.
Effects of pharmacological inhibition of plasminogen binding on liver regeneration in rats
Authors: Miura Atsushi , Ishiguro Kyoko , Koizumi Kouta , Yaita Yuki , Ozaki-Masuzawa Yori , Hosono Takashi , Seki Taiichiro 
Published: September 2017

Abstract
The fibrinolysis system is thought to play an important role in liver regeneration. We previously found that plasminogen (Plg) is localized to the cell surface of regenerating liver tissue as well as proliferating hepatocytes in vitro. Here, we investigated the significance of Plg binding to the cell surface during liver regeneration. Pre-administration of tranexamic acid (TXA), which is a competitive inhibitor of Plg binding, to hepatectomized rats mildly delayed restoration of liver weight in vivo. Although binding of Plg to the cell membrane decreased following TXA administration, TXA showed little effect on hepatocyte proliferation in rats. We also discovered that Plg treatment did not stimulate proliferation of primary rat hepatocytes in vitro. These results suggest that Plg/plasmin potentiates liver regeneration via a pathway distinct from those through which hepatocyte proliferation is stimulated.
GradDock: rapid simulation and tailored ranking functions for peptide-MHC Class I docking
Authors: Kyeong Hyun-Ho , Choi Yoonjoo , Kim Hak-Sung 
Published: September 2017

Abstract

Motivation
The identification of T-cell epitopes has many profound translational applications in the areas of transplantation, disease diagnosis, vaccine/therapeutic protein development and personalized immunotherapy. While data-driven methods have been widely used for the prediction of peptide binders with notable successes, the structural modeling of peptide binding to MHC molecules is crucial for understanding the underlying molecular mechanism of the immunological processes.

Results
We developed GradDock, a structure-based method for the rapid and accurate modeling of peptide binding to MHC Class I (pMHC-I). GradDock explicitly models diverse unbound peptides in vacuo and inserts them into the MHC-I groove through a steered gradient descent with a topological correction process. The simulation process yields diverse structural conformations including native-like peptides. We completely revised the Rosetta score terms and developed a new ranking function specifically for pMHC-I. Using the diverse peptides, a linear programming approach is applied to find the optimal weights for the individual Rosetta score terms. Our examination revealed that a refinement of the dihedral angles and a modification of the repulsion can dramatically improve the modeling quality. GradDock is five-times faster than a Rosetta-based docking approach for pMHC-I. We also demonstrate that the predictive capability of GradDock with the re-weighted Rosetta ranking function is consistently more accurate than the Rosetta-based method with the standard Rosetta score (approximately three-times better for a cross-docking set).

Availability and implementation
GradDock is freely available for academic purposes. The program and the ranking score weights for Rosetta are available at http://bel.kaist.ac.kr/research/GradDock.

Supplementary information
Supplementary data are available at Bioinformatics online.
A comprehensive assessment of long intrinsic protein disorder from the DisProt database
Authors: Necci Marco , Piovesan Damiano , Dosztányi Zsuzsanna , Tompa Peter , Tosatto Silvio C E 
Published: September 2017

AbstractMotivationIntrinsic disorder (ID), i.e. the lack of a unique folded conformation at physiological conditions, is a common feature for many proteins, which requires specialized biochemical experiments that are not high-throughput. Missing X-ray residues from the PDB have been widely used as a proxy for ID when developing computational methods. This may lead to a systematic bias, where predictors deviate from biologically relevant ID. Large benchmarking sets on experimentally validated ID are scarce. Recently, the DisProt database has been renewed and expanded to include manually curated ID annotations for several hundred new proteins. This provides a large benchmark set which has not yet been used for training ID predictors.ResultsHere, we describe the first systematic benchmarking of ID predictors on the new DisProt dataset. In contrast to previous assessments based on missing X-ray data, this dataset contains mostly long ID regions and a significant amount of fully ID proteins. The benchmarking shows that ID predictors work quite well on the new dataset, especially for long ID segments. However, a large fraction of ID still goes virtually undetected and the ranking of methods is different than for PDB data. In particular, many predictors appear to confound ID and regions outside X-ray structures. This suggests that the ID prediction methods capture different flavors of disorder and can benefit from highly accurate curated examples.Availability and implementationThe raw data used for the evaluation are available from URL: http://www.disprot.org/assessment/.Supplementary informationSupplementary data are available at Bioinformatics online.
Meta-server for automatic analysis, scoring and ranking of docking models
Authors: Anashkina Anastasia A , Kravatsky Yuri , Kuznetsov Eugene , Makarov Alexander A , Adzhubei Alexei A 
Published: September 2017

Abstract

Motivation
Modelling with multiple servers that use different algorithms for docking results in more reliable predictions of interaction sites. However, the scoring and comparison of all models by an expert is time-consuming and is not feasible for large volumes of data generated by such modelling.

Results
Quality ASsessment of DOcking Models (QASDOM) Server is a simple and efficient tool for real-time simultaneous analysis, scoring and ranking of data sets of receptor–ligand complexes built by a range of docking techniques. This meta-server is designed to analyse large data sets of docking models and rank them by scoring criteria developed in this study. It produces two types of output showing the likelihood of specific residues and clusters of residues to be involved in receptor–ligand interactions and the ranking of models. The server also allows visualizing residues that form interaction sites in the receptor and ligand sequence and displays 3D model structures of the receptor–ligand complexes.

Availability
http://qasdom.eimb.ru.

Supplementary information
Supplementary data are available at Bioinformatics online.
A novel SCCA approach via truncated
ℓ
1-norm and truncated group lasso for brain imaging genetics
Authors: Du Lei , Liu Kefei , Zhang Tuo , Yao Xiaohui , Yan Jingwen , Risacher Shannon L , Han Junwei , Guo Lei , Saykin Andrew J , Shen Li ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: September 2017

Abstract

Motivation
Brain imaging genetics, which studies the linkage between genetic variations and structural or functional measures of the human brain, has become increasingly important in recent years. Discovering the bi-multivariate relationship between genetic markers such as single-nucleotide polymorphisms (SNPs) and neuroimaging quantitative traits (QTs) is one major task in imaging genetics. Sparse Canonical Correlation Analysis (SCCA) has been a popular technique in this area for its powerful capability in identifying bi-multivariate relationships coupled with feature selection. The existing SCCA methods impose either the ℓ1-norm or its variants to induce sparsity. The ℓ0-norm penalty is a perfect sparsity-inducing tool which, however, is an NP-hard problem.

Results
In this paper, we propose the truncated ℓ1-norm penalized SCCA to improve the performance and effectiveness of the ℓ1-norm based SCCA methods. Besides, we propose an efficient optimization algorithms to solve this novel SCCA problem. The proposed method is an adaptive shrinkage method via tuning τ. It can avoid the time intensive parameter tuning if given a reasonable small τ. Furthermore, we extend it to the truncated group-lasso (TGL), and propose TGL-SCCA model to improve the group-lasso-based SCCA methods. The experimental results, compared with four benchmark methods, show that our SCCA methods identify better or similar correlation coefficients, and better canonical loading profiles than the competing methods. This demonstrates the effectiveness and efficiency of our methods in discovering interesting imaging genetic associations.

Availability and implementation
The Matlab code and sample data are freely available at http://www.iu.edu/∼shenlab/tools/tlpscca/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Intradermal Scalp Closure Using Barbed Suture in Cranial Tumor Surgeries: A Technical Note
Authors: Buttrick Simon S , Eichberg Daniel , Ali Sheikh C , Komotar Ricardo J 
Published: September 2017

Abstract

BACKGROUND AND IMPORTANCE
Traditional scalp closure technique following elective craniotomy involves placement of staples or a continuous running suture. Despite low complication rates, these techniques are often considered to be disfiguring by patients, contribute to the psychosocial trauma of brain surgery, and are associated with discomfort during postoperative staple or suture removal. Some authors have described scalp closure using intradermal absorbable suture, but this technique likely does not reach the tensile strength of closure using traditional methods, and requires knots at the apices of the incision, which can act as a nidus for infection.

CLINICAL PRESENTATION
We employed a barbed intradermal closure method in supratentorial elective craniotomies for tumor resection. Complication rates were recorded, and cosmetic outcomes were informally assessed. Intradermal closure with barbed sutures was utilized in 76 patients. At the 2-wk postoperative clinic visit, cosmetic outcomes were excellent in all cases. There was 1 superficial wound infection that presented 6 wk after a pterional craniotomy for low-grade glioma. This resolved with superficial wound revision and oral antibiotic therapy.

CONCLUSION
We present a novel scalp closure technique for craniotomies using intradermal barbed Monocryl suture. We have had excellent cosmetic outcomes, and the infection rate of 1.3% compares favorably to published rates. Further studies are required to quantify the improvement in patient satisfaction compared to conventional closure methods.
Optical polarization variations in the blazar PKS 1749+096
Authors: Uemura Makoto , Itoh Ryosuke , Liodakis Ioannis , Blinov Dmitry , Nakayama Masanori , Xu Longyin , Sawada Naoko , Wu Hsiang-Yun , Fujishiro Issei 
Published: September 2017

Abstract
We report on the variation in the optical polarization of the blazar PKS 1749+096 observed in 2008–2015. The degree of polarization (PD) tends to increase in short flares, having a time-scale of a few days. The object favors a polarization angle (PA) of 40°–50° at the flare maxima, which is close to the position angle of the jet (20°–40°). Three clear polarization rotations were detected in the negative PA direction associated with flares. In addition, a rapid and large decrease in the PA was observed in the other two flares, while another two flares showed no large PA variation. The light-curve maxima of the flares possibly tended to lag behind the PD maxima and color-index minima. The PA became −50° to −20° in the decay phase of active states, which is almost perpendicular to the jet position angle. We propose a scenario to explain these observational features, where transverse shocks propagate along curved trajectories. The favored PA at the flare maxima suggests that the observed variations were governed by the variations in the Doppler factor, δ. Based on this scenario, the minimum viewing angle of the source, $\theta _\mathrm{min} = {4 {^{\circ}_{.}} 8}$–6${^{\circ}_{.}}$6, and the location of the source, Δr ≳ 0.1 pc, from the central black hole were estimated. In addition, the acceleration of electrons by the shock and synchrotron cooling would have a time-scale similar to that of the change in δ. The combined effect of the variation in δ and acceleration/cooling of electrons is probably responsible for the observed diversity of the polarization variations in the flares.
Income Mobility, Income Risk, and Welfare
Authors: Krebs Tom , Krishna Pravin , Maloney William F 
Published: September 2017

AbstractThis paper presents a framework for the quantitative analysis of individual income dynamics, mobility, and welfare, with ex ante identical individuals facing a stochastic income process and market incompleteness, implying that they are unable to insure against persistent shocks to income. We show how the parameters of the income process can be estimated using repeated cross-sectional data with a short panel dimension and use a simple consumption-saving model for quantitative analysis of mobility and welfare. Our empirical application, using data on individual incomes from Mexico, provides striking results. Most of the measured income mobility is driven by measurement error or transitory income shocks and is therefore (almost) welfare neutral. Only a small part of measured income mobility is due to either welfare-reducing income risk or welfare-enhancing catching-up of low-income individuals with high-income individuals, both of which, nevertheless, have economically significant effects on social welfare. Strikingly, roughly half of the mobility that cannot be attributed to measurement error or transitory income shocks is driven by welfare-reducing persistent income shocks. Decomposing mobility into its fundamental components is thus crucial from the standpoint of welfare evaluation.
Medicate or Meditate? Greater Pain Acceptance is Related to Lower Pain Medication Use in Persons With Chronic Pain and Spinal Cord Injury
Authors: Kratz Anna L. , F. Murphy John , Kalpakjian Claire Z. , Chen Philip 
Published: September 2017

Objectives:
There is little information about whether use of pain self-management skills that are common targets of psychosocial interventions for pain are associated with reduced reliance on pain medications. The aim of this study was to test whether higher chronic pain acceptance, which is a readily modified pain self-management approach, is related to lower use of pain medications (eg, opioid medications, and gabapentinoids) in a sample with chronic pain and spinal cord injury (SCI).

Materials and Methods:
This is a cross-sectional survey study of pain medication use, pain severity and distribution (Brief Pain Inventory [BPI]), depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]), and chronic pain acceptance (Chronic Pain Acceptance Questionnaire [CPAQ]) administered to a sample of 120 adults with chronic pain and SCI.

Results:
Regression results indicated that, above and beyond the effects of pain intensity, pain distribution, and depressive symptoms, higher pain acceptance was related to lower use of all types of pain medications, and lower odds of using opioid medications or gabapentinoids. Pain intensity was not related to pain medication use, but greater pain distribution was related to using more pain medications in general and to greater odds of using gabapentinoids.

Discussion:
Findings from this study indicate that those with chronic pain and SCI who have a more accepting orientation to pain are less reliant on pain medications, and thereby experience lower risks associated with medication consumption. Longitudinal, daily process, and clinical trial studies are needed to better understand the association between pain acceptance and pain medication consumption.
Stigma and Pain in Adolescents Hospitalized for Sickle Cell Vasoocclusive Pain Episodes
Authors: Martin Sarah R. , Cohen Lindsey L. , Mougianis Ifigenia , Griffin Anya , Sil Soumitri , Dampier Carlton 
Published: September 2017

Objectives:
Sickle cell disease (SCD) pain and hospitalizations increase during adolescence and adolescents with SCD may be at-risk for experiencing health-related stigma, which may result in poor health outcomes. This study examined relations among health-related stigma, pain interference, social support, quality of life (QOL), and hospital outcomes (ie, loneliness, pain reduction, and length of stay [LOS]) in adolescents hospitalized with SCD pain.

Materials and Methods:
Twelve- to 18-year-old adolescents (N=92) hospitalized with SCD pain completed measures of stigma, pain interference, social support, QOL, and state loneliness. Reduction of pain intensity during hospitalization and LOS were collected from medical chart review.

Results:
Higher stigma was associated with higher pain interference, lower QOL, more loneliness, and less pain reduction in the hospital. Pain interference was positively associated with LOS.

Discussion:
These preliminary findings highlight the importance of assessing and addressing SCD-related stigma and pain interference in adolescents hospitalized for SCD pain as these factors may influence treatment outcomes.
Randomized Controlled Trial of Telephone-delivered Cognitive Behavioral Therapy Versus Supportive Care for Chronic Back Pain
Authors: Rutledge Thomas , Atkinson J. Hampton , Chircop-Rollick Tatiana , D’Andrea John , Garfin Steven , Patel Shetal , Penzien Donald B. , Wallace Mark , Weickgenant Anne L. , Slater Mark 
Published: September 2017

Objective:
The objective of this study was to evaluate the efficacy of a telephone-delivered, home-based cognitive-behavioral intervention for chronic low back pain in comparison to a matched supportive care (SC) treatment.

Methods:
Participants (N=66) were patients with chronic back pain that were randomized to either an 8-week Cognitive-Behavioral Therapy (CBT) or a SC condition matched for contact frequency, format, and time. Participants completed validated measures of improvement in back pain disability, pain severity, and overall improvement.

Results:
Intent-to-treat analyses at posttreatment showed that the treatment groups not show significantly different improvements in back pain disability (mean changes, −2.4 and −2.6 for CBT and SC, respectively; Cohen d, 0.49 and 0.55, respectively) or reductions in pain severity (mean changes, −0.9 and −1.4 for CBT and SC respectively; Cohen d, 0.50, and 0.90, respectively). Participants rated their overall improvement levels at 31% (CBT) versus 18.5% (SC).

Discussion:
Results from this clinical trial suggest that home-based, telephone-delivered CBT and SC treatments did not significantly differ in their benefits for back pain severity and disability, and may warrant further research for applications to hospital settings. Major limitations included recruitment difficulties that underpowered primary analyses, the lack of objective improvement measures, and the absence of a usual care/untreated control group for comparisons.
Associations of Early Opioid Use With Patient-reported Outcomes and Health Care Utilization Among Older Adults With Low Back Pain
Authors: Gold Laura S. , Hansen Ryan N. , Avins Andrew L. , Bauer Zoya , Comstock Bryan A. , Deyo Richard A. , Heagerty Patrick J. , Rundell Sean D. , Suri Pradeep , Turner Judith A. , Jarvik Jeffrey G. 
Published: September 2017

Objectives:
The objective of this study was to compare outcomes and health care utilization of older patients who did versus did not fill opioid prescriptions within 90 days of initiating care for low back pain.

Materials and Methods:
For patients ≥65 years with new back pain visits, we used propensity scores to match those who filled no opioid prescriptions to those who filled ≥2 opioid prescriptions within 90 days (and the first opioid prescription within 30 d) of the index visit. Over 24 months, we examined patient-reported outcomes, health care utilization, and subsequent opioid prescription fills.

Results:
Among 1954 patients eligible for matching, 238 (12%) filled ≥2 opioid prescriptions within 90 days; 200 of these were matched to controls. Patients with versus without early opioid prescriptions had similar patient-reported outcomes but were more likely to have filled ≥1 opioid prescription 18 to 24 months after the index visit (odds ratio [95% confidence interval]=2.4 [1.5-3.9]) and to have had ≥1 visit to the emergency department in the subsequent 24 months (OR, 1.6; 95% confidence interval, 1.0-2.5).

Discussion:
Among older patients with new back pain visits, filling ≥2 opioid prescriptions within 90 days of the visit was associated with similar back pain-related outcomes but increased likelihood of filling opioid prescriptions 18 to 24 months later compared with matched patients who did not fill early opioid prescriptions.