bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamics of Asymmetrically Stenotic Vertebral Arteries Based on Fluid-solid Coupling
Authors: zheng yilin , feng Haiquan , He Chen , Su Juan 
Published: October 2024

Abstract

Stenosis in the vertebral artery, often associated with atherosclerosis, presents complexities regarding the relationship between internal resistance, shear stress and the geometric characteristics of stenosis lesions. This study aims to elucidate these relationships through computational simulations utilizing medical imaging data of human vertebral arteries. Various models representing different stenotic configurations were constructed, allowing for comprehensive analysis via Computational Fluid Dynamics (CFD) and Fluid-Structure Interaction (FSI) methods. Hemodynamic parameters such as blood flow velocity, time-averaged wall shear stress (TWASS), oscillation shear index (OSI), relative retention time (RRT), and solid mechanics indicators including total deformation and vascular Von-Mises stress were evaluated. Our findings revealed that different lesion modes had different impacts on the blood flow field in the vertebral artery. Upon comparing the mathematical model with CFD and FSI results, it was found that an augmented stenosis rate led to the creation of a watershed environment within the blood vessel, thereby expediting the onset of atherosclerosis. In cases where the vertebral artery experienced complete narrowing due to a consistent stenosis rate, there was a substantial rise in blood flow velocity. Neglecting timely intervention to alter the blood flow environment heightened the peril of triggering vascular dissection or even puncturing the blood vessel wall directly.
A Hybrid Prediction Model for International Crude Oil Price Based on Variational Mode Decomposition with BiTCN-BiGRU-Attention Deep Learning Techniques
Authors: Bi Mengyu , Liu Ziyun , Yang Xiaozhong 
Published: October 2024

Abstract

Predicting the price and volatility of international crude oil futures is a complex task. This paper presents a novel hybrid prediction model, the VMD-BiTCN-BiGRU-Attention, which integrates variational mode decomposition (VMD) and advanced deep learning techniques to forecast the nonlinear, non-stationary, and time-varying characteristics of crude oil price sequences. Initially, the price sequence is decomposed into multiple modes using VMD, enabling the capture of different frequency components. Each mode is independently predicted using a bidirectional time convolutional network (BiTCN), which captures temporal sequence information and enhances long-term dependencies through dilated convolution. Subsequently, a bidirectional gated recurrent unit (BiGRU) models the temporal dependencies more effectively, while an attention mechanism adjusts the weights of the BiGRU outputs to emphasize critical information. The model’s predictions are optimized with the Adam algorithm. Empirical results demonstrate that the model is adept at forecasting non-stationary and nonlinear international crude oil prices. Furthermore, the Diebold-Mariano (DM) test confirms that this model surpasses 15 other models regarding accuracy and performance, achieving optimal results with key metrics: R² = 0.9953, RMSE = 1.4417, MAE = 0.7973, and MAPE = 1.5213%. These findings underscore its potential for enhancing crude oil price prediction.
Spatial Analysis of Fire Incidents and Urban Vulnerabilities in the Accra Metropolis of Ghana
Authors: Amoako Richard Dickson 
Published: October 2024

Abstract

Fire incidents in the Accra Metropolis have caused significant damage to property and human lives over the years. However, spatial data on the distribution and causes of these incidents are inadequate in Ghana. This study analyzes the spatial distribution of fire occurrences in the Accra Metropolitan Assembly (AMA) from 2010 to 2022, classifying land uses into commercial, industrial, residential, and institutional categories. Data from the Ghana National Fire Service were analyzed using Geographic Information System (GIS) tools, including ArcMap, Getis-Ord hotspot analysis, and Moran's I autocorrelation. The study found that the Central Business District (CBD), primarily serving commercial functions, was the hotspot zone for fire incidents. Poorly planned residential areas also suffered from frequent fire outbreaks. The study attributes fire incidents in the CBD to inadequate urban planning, characterized by unapproved structures serving as squatter settlements. Illegal electricity connections associated with these unregulated buildings were identified as a proximate cause of fires in and around the CBD. The spatial analysis revealed changing patterns of fire incidents over time, with some well-planned areas experiencing unexpected increases in fire cases in recent years. This research highlights the critical relationship between urban planning and fire risk management in the Accra Metropolis. It emphasizes the need for targeted interventions in high-risk areas and comprehensive urban renewal projects to minimize fire hazards. The findings provide valuable insights for urban planners, policymakers, and fire management authorities to develop more effective strategies for fire prevention and response in rapidly growing African cities.
Changes in Micropolar Thermoelastic Behavior in the 3PHL Framework due to Rotation and Nonlocality
Authors: Fathy Rania A. , Eraki Ebtesam E. M. , Othman Mohamed I. A. 
Published: October 2024

Abstract

The main objective of this paper is to explore the effect of the nonlocal parameter on a two-dimensional micropolar thermoelastic isotropic rotating medium using the three-phase-lag (3PHL) framework. Through application of normal mode method, exact expressions for the temperature, microrotation, displacement, stress components have been obtained. Numerical solutions for these physical quantities were calculated and visually represented with MATLAB 2013, taking into account the material characteristics of magnesium crystal. The study's findings shed important light on how nonlocal thermoelastic media behave with the combined influence of micro-polarity and rotation, which could lead to improvements in material design and performance for various applications. The findings reveal significant differences between three theories, particularly with or without of the nonlocal parameter and different angular velocity values. Additionally, under rotational influence, the predictions made by the 3PHL model tend to fall between the results from the theories of L-S and G-N III.
Overexpression of miR-192 in Fibroblasts accelerates wound healing in diabetic rats
Authors: Karam Forouzan , Sayadi Mahtab , Dadi Saeedeh , Sarab Gholamreza Anani 
Published: October 2024

Abstract

Background: Diabetic Foot Ulcer (DFU) is a severe diabetic complication.Transplantation of skin substitutes, stem cells, and Platelet-Rich Plasma (PRP) treatments are promising tools to promote ulcer healing in diabetes. An important aspect of the remodelling phase of wound healing is collagen deposition. miR-192 increases the expression of COL1A2 by specifically targeting Smad-interacting protein 1 (SIP1). This study was designed to investigate the impact of combined treatment with platelet-rich plasma and fibroblast cells expressing miR-192 on the healing process of wounds using an experimental diabetic animal model.
Methods: After transfection of HDF cells and induction of increased miR-192 expression, relative changes in COL1A2gene expression were determined by the RT-PCR method. Rats were randomly divided into 6 groups: non-diabetic control group, diabetic control, backbone, PRP, miR-192, and PRP+miR-192 groups. Diabetes was induced in male Wistar rats of all treated groups except non-diabetic control through a 21-day high-fat diet and an intraperitoneal injection of 40 mg/kg streptozotocin. A 10mm skin biopsy punch was used to create two full-thickness wounds on the dorsal part of the upper body in all six groups of animals. Hematoxylin-Eosin and Mason's trichrome staining were used to evaluate the wounds and analyze histological changes.
Results: The overexpression of miR-192 in HDF cells resulted in a significant increase in COL1A2 gene expression, which was 15.77-fold higher than the control group. PRP and pLenti-III-miR-192-GFP-expressing cells significantly increased wound closure rates, granulation tissue area, and collagen fiber density in rats, according to a histological examination.
Conclusion: The combined use of PRP and HDFs expressing pLenti-III-miR-192-GFP speeds up the healing of wounds by increasing collagen expression, demonstrating the efficacy of this approach in improving wound healing results.
Characterization of the overexpressed recombinant human α11 integrin I domain in Escherichia coli for functional analysis
Authors: Tavili Elaheh , Dabirmanesh Bahareh , Amanlou Massoud , Khajeh Khosro 
Published: October 2024

Abstract

Integrins are crucial adhesion receptors involved in cell-matrix and cell-cell interactions. Integrin α11β1 has been linked to tumor progression, metastasis, angiogenesis, fibrotic diseases, and wound healing. The I domain of integrin α11 plays a vital role in ligand binding, integrin activation, and cell signaling. In this study, we focused on expressing the I domain of integrin α11 in E. coli C41 (DE3) using lysis buffers like Triton X-100, sarkosyl, and urea. We also examined the effect of osmolytes on protein stability. A solid-phase assay assessed the binding of the recombinant I domain to type I collagen. Our findings showed that expression condition changes did not affect the I domain's solubility. We successfully obtained a soluble I domain using sarkosyl lysis buffer and purified it via nickel affinity chromatography, optimizing its stability with 40 mM mannitol. The binding of the I domain to type I collagen is concentration-dependent. This study outlines a method for expressing, purifying, and stabilizing the recombinant I domain of integrin α11, which may facilitate further investigations into this protein.
Experimental study on the treatment of high COD metal degreasing cleaning wastewater by coagulation and two-stage Fenton oxidation
Authors: Ai Shengshu , Yang Siwen , Sun Xuejian , Wang Fan , Zhang Ying , Zhang Haigang , Bian Dejun 
Published: October 2024

ABSTRACT

In this study, based on the water quality characteristics of metal degreasing cleaning wastewater , wastewater treatment by coagulation combined with two-stage Fenton oxidation was proposed. The results showed that when the dosage of PAC was 5 g/L and the dosage of CPAM was 8 mg/L, with an initial pH of 8, rapid stirring at 350 rpm for 3 min followed by slow stirring at 200 rpm for 15 min, the optimal removal rate of chemical oxygen demand (COD) reached 74.08%. Primary Fenton oxidation is mainly aimed at decomposing macromolecular long-chain pollutants and removing some pollutants. The highest COD removal rate was achieved at 95.07% when the dosage of H2O2 was 4 mol/L, the dosage of FeSO4 was 40 g/L, the oxidation lasted for 60 min, the initial pH was 2, the effluent pH was 8, and the settling time was 90 min. The two-stage Fenton oxidation process provided further advanced treatment. With a reagent ratio of 1:0.5, the effluent COD concentration was reduced to 457 mg/L, meeting the third class standard of the `Integrated Wastewater Discharge Standard' (GB 8978 1996).
Impact of Melatonin Supplementation on Glycemic Parameters in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis
Authors: Abadi Reza Nejad Shahrokh , Jazinaki Mostafa Shahraki , Bahari Hossein , Rashidmayvan Mohammad , Amini Mohammad Reza , Aliakbarian Mohsen , Khodashahi Rozita , Malekahmadi Mahsa 
Published: October 2024

Background:
Several previous studies indicated that melatonin supplementation may positively
affect glycemic control in patients with diabetes. However, research on the influence of melatonin supplementation
on glycemic parameters remains inconclusive. Therefore, this study aimed to assess the impacts of melatonin
supplementation on glycemic parameters in type 2 diabetes by conducting a meta-analysis.

Methods:
PubMed/Medline, Scopus, and Web of Science were comprehensively searched until July 2024 to
find eligible randomized clinical trials (RCTs). The overall effect sizes were estimated by using the randomeffect
model and presented as weighted mean differences (WMD) with a 95% confidence interval (CI). Furthermore,
the heterogeneity among the included trials was assessed by performing the Cochran Q test and interpreted
based on the I² statistic.

Results:
Of the 1361 papers, eight eligible RCTs were included in this meta-analysis. Our findings indicated
that melatonin supplementation significantly decreased fasting blood glucose (WMD = -12.65 mg/dl; 95% CI:
-20.38, -4.92; P = 0.001), insulin (WMD = -2.30 μU/ml; 95% CI: -3.20, -1.40; P < 0.001), hemoglobin A1c
(WMD = -0.79 %; 95% CI: -1.28, -0.29; P = 0.002), and HOMA-IR (WMD, -0.83; 95% CI: -1.59 to - 0.07;
P = 0.03).

Conclusion:
According to the results of the current meta-analysis, persons with type 2 diabetes who supplement
with melatonin had improved glycemic control. It looks that supplementing with melatonin at a dose exceeding
6 mg daily for over a period of 12 weeks may be more successful than other forms of intervention.
Nevertheless, further research with larger sample sizes is necessary to draw definitive conclusions.
Comparative Study on Enhanced Skin Permeation Efficiency of Phenylephrine via Novel Lipid Vesicles: A Promising Approach in Preventing Chemotherapy-induced Alopecia Management
Authors: Shankar Ravi , Kumar Manish , Upadhyay Prabhat Kumar 
Published: October 2024

Background:
Chemotherapy-induced alopecia (CIA) significantly impacts patients'
emotional and psychological well-being and treatment regimen. Phenylephrine, a topical vasoconstrictor,
can potentially reduce hair loss by limiting chemotherapy drug delivery to hair follicles.
However, effective delivery of Phenylephrine through the skin remains challenging. This
study investigates lipid vesicles as delivery vehicles to enhance Phenylephrine's skin permeation
and sustained release due to their biocompatibility and encapsulation capabilities.

Objective:
This study aimed to formulate and compare different lipid vesicles of Phenylephrine
HCl for enhanced permeation through the skin for deep dermal delivery with sustained release of
the drug so as to achieve local vasoconstriction.

Methods:
Phenylephrine-loaded ethosomes, invasomes, and transfersomes were prepared and
characterized for particle size (PS), polydispersity index (PDI), and entrapment efficiency
(EE %). These lipid vesicles were incorporated into hydrogels to facilitate sustained drug release
to deep dermal layers where they could target local vasculature and cause vasoconstriction. The
prepared vesicular gels were evaluated for various permeation parameters.

Results:
The entrapment efficiencies of the developed vesicles ranged from 49.51 ± 3.25% to
69.09 ± 2.32%, with vesicle sizes ranging from 162.5 ± 5.21 nm to 321.32 ± 3.75 nm. Statistical
analysis revealed significantly higher flux values (Jss, μg/cm2 h) of 0.6251, 0.6314, and 0.4075
for invasomal gel, ethosomal gel, and transfersomal gel, respectively, compared to plain gel
(0.1254) (p < 0.005). The enhancement factors were 4.9848, 5.0350, and 3.2496 for invasomal
gel, ethosomal gel, and transfersomal gel, respectively, indicating superior permeation abilities
of ethosomal and invasomal formulations.

Conclusion:
The results demonstrate that ethosomal and invasomal formulations were efficient
in delivering the drug to deep dermal layers of skin in a sustained manner. These findings suggest
that these Lipidic vesicles would be able to target the local vasoconstrictor to vasculature,
causing reduced hair loss by limiting chemotherapy drug delivery to hair follicles and managing
chemotherapy-induced alopecia.
Comprehensive PRISMA Based Systematic Review: Exploring the Phytochemistry, Pharmacological Profile and Clinical aspects of Panax ginseng
Authors: Singh Sonia , Agrawal Ronak , Sharma Himanshu 
Published: October 2024

Introduction:
Ginseng, a perennial herb belonging to the Araliaceae family, is renowned
for its traditional and folk uses. The Panax ginseng C.A. Meyer species is predominantly
found in Asian countries, including Japan, China, and Korea.

Materials and Methods:
This manuscript offers valuable insights into the cultivation, collection,
morphology, phytochemistry, pharmacological properties, and clinical studies of Ginseng. The
data was meticulously gathered from diverse electronic resources, such as PubMed, Scopus, Science
Direct, and Web of Science, spanning from 1963 to 2023.

Results:
Ginseng contains various bioactive components, including carbohydrates, polyacetylenic
alcohols, polysaccharides, ginsenosides, peptides, vitamins, and fatty acids. The biological attributes
of ginsenosides, which include anti-diabetic, anti-cancer, anti-oxidant, and anti-inflammatory
activities, render them especially remarkable.

Conclusion:
This manuscript comprehensively explores the versatile therapeutic applications of
ginseng in the treatment of various types of cancers.
Association of Angiotensin Converting Enzyme Phenotypes and Polymorphisms with Clinical Outcomes in SARS-CoV2 Patients with Hypertension in an Urban Emergency Department
Authors: Prendergast Heather M. , Kotini-Shah Pavitra , Pobee Ruth , Richardson Maxwell , Ardati Amer , Darbar Dawood , Khosla Shaveta 
Published: October 2024

Introduction:
The role of Angiotensin-converting enzyme (ACE and ACE2) phenotypes
and polymorphisms in modulating severe acute respiratory syndrome coronavirus (SARS--
CoV2) infection in hypertensive patients remains unclear. Our objective was to determine the distribution
of ACE and ACE2 receptor phenotypes by patient demographics and correlate ACE and
ACE2 levels of activity with SARS-CoV-2 outcomes.

Methods:
Hypertensive patients treated for SARS-CoV-2 at an urban emergency department (ED)
were prospectively enrolled in a cohort study between August 2020 and April 2021. Blood samples
were collected during ED visits or hospitalization. Outcome measures including hospitalization,
intensive care unit (ICU) admission, and 30-day mortality were obtained from electronic
health records. Multivariable logistic regression was used.

Results:
Of the 150 patients enrolled, 60% were Black, 32% Hispanic/Latinx, 4% Non-Hispanic
Whites, and 4% others. The mean age was 59 (+/-14) years. The rate of hospitalization was high
(86%) and Hispanic/Latinx had a higher likelihood of ICU admission. Patients harboring the
rs2285666 genotype TT, AA, and GC alleles were more likely to be admitted to ICU, and those
with TT and AA had higher mortality. The ACE level was a significant predictor of hospitalization
with a protective effect in both unadjusted and adjusted results. Hispanics/Latinx had a four
times higher likelihood of ICU admission compared to all others, and age was significantly associated
with 30-day mortality.

Conclusion:
Our results show that even after adjusting for age, race, and sex, ACE levels remained
a predictor of hospitalization. ACE/ACE2 phenotypes and genotypes potentially play an
important role in disease progression in SARS-CoV-2 patients.
Doramectin Induces Apoptosis in B16 Melanoma Cells
Authors: Crotts Megan S. , Jacobs Jena C. , Baer Robert W. , Cox James L. 
Published: October 2024

Introduction/Objective:
Metastatic melanoma resists current pharmacological regimens that act
through apoptosis. This indicates that therapies acting via non-apoptotic cell-death pathways could be pursued.
Doramectin has shown promising results in another cancer of neural crest origin, neuroblastoma, through the
inhibition of growth via autophagy. Our research hypothesis is that doramectin induces autophagy in B16F10
melanoma cells.

Methods:
Cells were treated with doramectin (15 uM) or a combination of both doramectin and a cell-death inhibitor,
compared to untreated control cells (media), and then analyzed with MTT analysis. Likewise, MDC analysis
was completed to detect autophagy involvement with doramectin treatment. Flow cytometry and TUNEL
Assay were conducted to observe cell death-related effects.

Results:
MTT analysis of doramectin-treated cells displayed a decrease in cell growth compared to control.
Apoptotic morphology was prominent in melanoma cells treated with doramectin. Increased autophagy was not
detected by fluorometric microscopic analysis. Flow cytometry analysis of doramectin-treated cells showed apoptosis
as a major mode of cell death with some necrosis.

Conclusion:
Doramectin induces a novel cell-death mechanism in melanoma compared to other forms of cancer
and should be studied as an effective anti-cancer agent for melanoma treatment.
Inter-atrial Septum Stenting in Congenital Heart Disease Patient: A Case Series in Indonesia
Authors: Prakoso Radityo , Kurniawati Yovi , Siagian Sisca Natalia , Sembiring Aditya Agita , Sakti Damba Dwisepto Aulia , Mendel Brian , Lelya Olfi , Lilyasari Oktavia 
Published: October 2024

Background:
Inter-atrial septum (IAS) stenting in duct-dependent congenital heart
disease patient has shown to be an effective way to maintain inter-atrial blood flow, however it is
still considered a high risk procedure and inter-atrial septum stenting remains a low-frequency
procedure.

Method:
A single-center observational cohort study was carried out at the National Cardiovascular
Center Harapan Kita (NCCHK) between April 2019 and April 2023. This study included
duct-dependent congenital heart disease patients. The extracted data were baseline
characteristics, clinical findings, complications, and outcomes of the patients.

Result:
Eleven patients with duct-dependent physiology were intervened with inter-atrial septum
stenting. The patients were 4 females and 7 males with the median age of implantation being 150
days (range 11-703 days) and the median weight being 3.9 (range 2.8-9) kg, with 2 patients
weighing less than 3 kg. The average stent diameter was 8.50 (2.03) mm with an average length
of 24.45 (7.94) mm. Non-restrictive atrial flow was successfully achieved in 90.90% of the procedures,
corresponding to 10 patients.

Conclusion:
Inter-atrial septum stenting in duct-dependent congenital heart disease patients produces
reliable patency with a very good intra-procedural success rate.
Clove Aqueous Extract Alleviates Acute Kidney Injury Induced by Folic Acid in Rats
Authors: Abd El Aziz Yomna Esam , Soliman Amel Mahmoud , Fahmy Sohair Ramadan , Mohamed Ayman Saber 
Published: October 2024

Background:
Acute Kidney Injury (AKI) is a common clinical disease that has a high
incidence and mortality rate. Clove, a robust natural source of bioactive chemicals and rich in secondary
metabolites, plays a wide range of biological roles.

Aim:
The present study aimed to assess the ameliorative efficacy of clove extract against acute renal
damage induced by folic acid in rats.

Methods:
Gas Chromatography/Mass Spectrometry (GC/MS) was used to investigate the main
components of clove extract. Folic acid, at a dose of 250 mg/kg, was delivered intraperitoneally to
rats to induce AKI. Eighteen rats were divided into three groups: control, AKI, and AKI + clove extract
(500 mg/kg).

Results:
The administration of clove extract significantly restored the levels of creatine, urea, uric
acid, sodium, potassium, chloride, creatinine clearance, and microalbumin to nearly normal levels.
Also, clove water extract inhibited oxidative stress by decreasing concentrations of Malondialdehyde
(MDA) and Nitric Oxide (NO). Furthermore, clove extract elevated the levels of Glutathionereduced
(GSH), Catalase (CAT), and Glutathione S-transferase (GST). Kidney section histology
showed notable improvements after the administration of clove extract.

Conclusion:
The clove water extract has been found to contain many bioactive components possessing
antioxidant and anti-inflammatory properties, effectively protecting against acute renal injury.