bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperthermic intracavitary nanoaerosol therapy (HINAT) as an improved approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC): Technical description, experimental validation and first proof of concept
Authors: Göhler Daniel , Große Stephan , Bellendorf Alexander , Falkenstein Thomas Albert , Ouaissi Mehdi , Zieren Jürgen , Stintz Michael , Giger-Pabst Urs 
Published: December 2017

Background: The delivery of aerosolised chemotherapeutic substances into pressurised capnoperitonea has been reported to be more effective than conventional liquid chemotherapy for the treatment of peritoneal carcinomatosis. However, recent reports reveal limitations of the currently available technology.Material and Methods: A novel approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC), called hyperthermic intracavitary nanoaerosol therapy (HINAT), based on extracavitary generation of hyperthermic and unipolar charged aerosols, was developed. The aerosol size distribution, the spatial drug distribution and in-tissue depth penetration of HINAT were studied by laser diffraction spectrometry, differential electrical mobility analysis, time of flight spectrometry, scintigraphic peritoneography and fluorescence microscopy. All experiments were performed contemporaneous with conventional PIPAC for the purpose of comparison. Furthermore, a first proof of concept was simulated in anesthetised German Landrace pigs.Results: HINAT provides a nanometre-sized (63 nm) unipolar-charged hyperthermic (41 °C) drug aerosol for quasi uniform drug deposition over the whole peritoneum with significantly deeper drug penetration than that offered by conventional PIPAC.
The Parametric Instability of Alfvén Waves: Effects of Temperature Anisotropy
Authors: Tenerani Anna , Velli Marco , Hellinger Petr 
Published: December 2017

Abstract
We study the stability of large-amplitude, circularly polarized Alfvén waves in an anisotropic plasma described by the double-adiabatic/CGL closure, and in particular the effect of a background thermal pressure anisotropy on the well-known properties of Alfvén wave parametric decay in magnetohydrodynamics (MHD). Anisotropy allows instability over a much wider range of values of parallel plasma beta (β
∥) when ξ = p
0⊥/p
0∥ > 1. When the pressure anisotropy exceeds a critical value, ξ ≥ ξ* with ξ* ≃ 2.7, there is a new regime in which the parametric instability is no longer quenched at high β
∥, and in the limit β
∥ ≫ 1, the growth rate becomes independent of β
∥. In the opposite case of ξ < ξ*, the instability is strongly suppressed with increasing parallel plasma beta, similarly to the MHD case. We analyze marginal stability conditions for parametric decay in the (ξ, β
∥) parameter space and discuss possible implications for Alfvénic turbulence in the solar wind.
Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS
Authors: Kuehlewein Laura , Kitiratschky Veronique , Gosheva Mariya , Edwards Thomas L. , MacLaren Robert E. , Groppe Markus , Kusnyerik Akos , Soare Cristina , Jackson Timothy L. , Sun Chen-Hsin , Chee Caroline , Sachs Helmut , Stingl Krunoslav , Wilhelm Barbara , Gekeler Florian , Bartz-Schmidt Karl Ulrich , Zrenner Eberhart , Stingl Katarina 
Published: December 2017

BACKGROUND AND OBJECTIVE:
The aim of this study was to assess changes in retinal structure and thickness after subretinal implantation of the Retina Implant Alpha IMS (Retina Implant AG, Reutlingen, Germany).

PATIENTS AND METHODS:
Spectral-domain optical coherence tomography (SD-OCT) imaging was performed to assess the structure and thickness of the retina anterior to the microphotodiode array preoperatively, within 6 weeks and 6 months ± 1 month after implantation. Thickness measurements were performed using the distance tool of the built-in software. Three thickness measurements were performed in each of the four quadrants of the retina on the microchip within 6 weeks and 6 months ± 1 month after implantation.

RESULTS:

The mean ± standard deviation change in retinal thickness from within 6 weeks to 6 months ± 1 month after implantation in all four quadrants combined was 24 μm ± 68 μm. None of the tested variables (location, time, or their interaction) had a statistically significant effect on the mean retinal thickness (
P
= .961,
P
= .131, and
P
= .182, respectively; n = 19).

CONCLUSION:
The authors report on qualitative and quantitative findings in retinal structure in 27 patients after subretinal implantation of the Retina Implant Alpha IMS using OCT technology. No significant changes of retinal thickness could be observed in a period of 6 months after surgery. With more patients receiving subretinal implants and with advanced OCT technology, the data set will be extended to study possible changes in retinal structure in finer detail.

[
Ophthalmic Surg Lasers Imaging Retina
. 2017;48:993–999.]
Physical activity, BMI and metabolic risk in Portuguese adolescents
Authors: Santos Fernanda Karina dos , Gomes Thayse Natacha Queiroz Ferreira , Souza Michele Caroline de , Chaves Raquel Nichele , Santos Daniel Monteiro de Vilhena , Pereira Sara Isabel Sampaio , Borges Alessandra Da Silva , Maia José António Ribeiro 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n1p103 It has been reported, in the last decades, a significant decrease in physical activity (PA) levels, with a consequent increase in obesity and metabolic risk factors among youth. The aims of this study were to describe PA levels, the prevalence of overweight/obesity and metabolic risk factors, and to examine the association between PA and body mass index (BMI) with metabolic risk among Portuguese youth. The sample comprises 212 Portuguese adolescents (12-16 years old). Height and weight were measured. PA was estimated with the Bouchard questionnaire (3 days recall), as well as with the use of a pedometer (used for 5 consecutive days). Metabolic risk factors comprised fasting glucose, triglycerides, HDL-cholesterol, systolic blood pressure and waist circumference. Subjects were classified as normal weight, overweight or obese according to BMI; the maturational status was indirectly estimated with the maturity offset procedure. A continuous metabolic risk score was computed (zMR) and PA values were divided into tertiles. Qui-square test, t-test and ANOVA were used in statistical analyses. SPSS 18.0 and WinPepi softwares were used and p<0.05. A moderate to high prevalence of overweight/obesity and HDL-cholesterol was found, as well as a high prevalence of high blood pressure and low to moderate PA levels among Portuguese youth. The relationship between BMI and zMR showed that obese adolescents have higher zMR when compared to normal weight or overweight adolescents. This finding suggests that increased levels of PA and reduction in the prevalence of overweight/obesity may have a positive role against the development of metabolic risk factors.
Thermoregulation of competitive artistic gymnastic athletes and non-athlete girls exercising in the heat
Authors: Leites Gabriela Tomedi , Sehl Paulo Lague , Cunha Giovani Dos Santos , Detoni Filho Adriano , Meyer Flavia 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n2p143 It’s unclear whether the combination of intense, chronic training and heat exposure during prepubescence improves thermoregulatory responses to exercise in artistic gymnastics athletes. The objective of this study was to compare thermoregulatory and perceptual responses between artistic gymnastics athletes and non-athlete girls while exercising both in heat and thermoneutral conditions. Seven athletes (8.7 ± 1.3 yrs) and 7 nonathletes (9.4 ± 1.5 yrs) cycled for 30 min at load (W) of ~55% VO2peak, on two separate occasions in a randomized order: heat (35˚C, 40% relative humidity) and thermoneutral conditions (24˚C, 50% relative humidity). Rectal temperature, heart rate, rate of perceived exertion, thermal sensation, thermal comfort and irritability were measured throughout the exercise. Initial rectal temperature was similar between athletes and non-athletes in both heat (37.2 ± 0.4 vs. 37.4 ± 0.2˚C, respectively) and thermoneutral conditions (37.3 ± 0.2 vs. 37.3 ± 0.3˚C). Final rectal temperature was similar between groups (38.0 ± 0.2 vs. 38.2 ± 0.2˚C in heat and 37.8 ± 0.2 vs. 37.9 ± 0.2˚C in thermoneutral conditions). Initial heart rate was lower in athletes in the heat (76 ± 7 vs. 91 ± 11 bpm, P = 0.01); however, throughout cycling, it became similar between groups. Athletes reported similar perceptual responses compared to non-athletes, with the exception of higher thermal comfort in the 10th minute of exercise in thermoneutral conditions (P = 0.003). It was concluded that athletes were similar to non-athletes with respect to thermoregulatory and perceptual responses during 30 min of cycling at similar relative intensities.
Association between private and public places and practice of physical activity in adults
Authors: Nakamura Priscila Missaki , Teixeira Inaian Pignatti , Hino Adriano Akira F , Kerr Jacqueline , Kokubun Eduardo 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n3p297 There are some studies that showed the relationship between built environment with practice of physical activity during leisure-time and active transportation in the adult population. However, this relationship may be influence by type and intensity of physical activity. The aim of this study was to verify association between public and private places for engaging in different types of physical activity in adults of Rio Claro City, Brazil. Cross sectional study with representative sample of 1588 adults with a mean age of 45.7±17.0 years completed the IPAQ-long form. Geographic Information System data were employed to assess the built environment. The time to different physical activity types were divided in actives (≥10 min/week) and inactive (<10 min/week). Poisson Multilevel Regression Analysis was performed in the Stata version 12.0. After adjusting for confounders, walking during leisure-time was positively associated with São Paulo’s Social Vulnerability Index (SSVI) categories of 1 (PR=2.77) through 5 (PR=1.94) and negatively associated with population density higher than 68 km/m2 (PR=0.70). Vigorous intensity physical activity was negatively associated with distance greater than 596 metes of private places to practice physical activity (PR=0.50). Total leisure time physical activity was positively associated with SSVI 1 (PR=2.48) and 5 (RP=1.89). Moderate intensity physical activity was not associated with built environment factors. There were differents associations between the built environment factors with leisure time PA except to moderate intensity physical activity.
Efeitos do polimento na potência aeróbia máxima em atletas de indoor soccer
Authors: Fortes Leonardo De Sousa , Vianna Jeferson Macedo , Silva Delton Manoel dos Santos , Gouvea Marcio André , Cyrino Edilson Serpeloni 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n3p341 The aim of this study was to analyze the effect of tapering on maximum aerobic power (VO2max) in young male indoor soccer athletes. Participants were 78 athletes aged 12-17 years randomly divided into experimental (EG) and control group (CG). Both groups did the same training planning until the last three weeks (tapering phase). Only EG performed tapering. Tapering lasted three weeks adopting the linear tapering method. VO2max was estimated by Yo-Yo intermittent Recovery Level 1 early in the season and in the last week of each. Univariate analysis of covariance (ANCOVA) was conducted for repeated measures to compare VO2max among groups according to mesocycle. The results presented effect of time (F (4.74)= 42.02, p = 0.01) and group (F (2.76) = 35.87, p = 0.01). Overall, the findings of this study suggest that the implementation of the tapering strategy in the last weeks of training is more efficient to improve VO2max than the constant maintenance of loads.
The Influence of Different Performance Level of Fencers on Simple and Choice Reaction Time
Authors: Balkó Štefan , Borysiuk Zbigniev , Šimonek Jaromír 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n4p391 In many sport disciplines reaction time plays a key role in the sport performance. It is good to point out for example ball games or fighting sports (fencing, karate etc.). The research is focused on detection of the differences in the simple and choice reaction time during visual stimulation among elite, sub-elite fencers and beginners. For the measurement a Fitrosword device and the SWORD software were used. An additional stimulus was added during measuring which should increase the overall number of stimuli, but shouldn’t force fencer to any reaction whatsoever. The results from presented study can be compared with Hicks law. The next focus of the study was to identify the difference in reaction time during two different movement tasks with different complexity movement requirements. The research was built up on a hypothesis that the results will differ among different performance groups of fencers. The difference however was overt among beginners and elite fencers (p = 0.0088, d = 0.5) in reaction time during different movement tasks (direct hit vs. lunge). The results of this research could be useful to trainers for training process organisation and increase the effectivity of muscle coordination during several movements in fencing.
Stability of behaviour patterns in the 200m breaststroke
Authors: Louro Hugo , Silva António J , Campaniço Jorge , Matos Telmo , Conceição Ana 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n4p401 The aim of this study was to analyse the stability of the breaststroke technique in five elite swimmers in a 200m event using a qualitative analysis. The codification of the behaviour of each swimmer during the execution of 20 cycles was achieved using an ad hoc observational instrument comprised of a system of categories and field formats to detect the behavioural patterns (T-patterns); software was used for identifying the technical behaviour of stable structures. The results showed that the stability behaviour varied depending on the swimmer, as the variations of codes in each round produced distinct configurations to determine the differences between cycles for the same swimmer. It was concluded that the instrument used in this study plays an important role through the existence of stable behaviour in the breaststroke technique. It was also concluded that there are distinct patterns and behaviours between swimmers during each lap of the race.
Stages of Behavior Change for physical activity and associated factors among technicaladministrative servers of a federal university
Authors: Berria Juliane , Teixeira Davi Monteiro , Minatto Giseli , Petroski Edio Luiz 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n4p471 The benefits that the regular practice of physical activity (PA) provides to health and its importance in preventing and fighting chronic diseases. The aim of this study was to identify the Stages of Behavior Change (SBC) for PA among technicaladministrative servers and its association with sociodemographic and health risk factors. This cross-sectional study investigated 622 technical-administrative servers (337 women) from a Brazilian federal university. SBC for PA, sociodemographic information (gender, age, marital status and educational level) and health risk factors (inadequate eating habits, excessive alcohol consumption, smoking, commuting and PA at work) were collected through questionnaires. Multinomial regression with adjustment for the hierarchical level was applied and significance level of 5% was adopted. The distribution of technical-administrative servers in SBC for PA identified prevalence of 9.1% and 6.5% in the pre-contemplation stage, 24.6% and 33.5% in contemplation, 33.3% and 22 6% in preparation, 5.6% and 12.2% in action and 27.4% and 25.2% in maintenance stages between men and women, respectively. Lower odds ratio of being in the preparation stage was identified among women (OR=0.62; CI95%=0.41; 0.93) while those with inadequate eating habits were more odds to be in the “pre-contemplation + contemplation” (OR=2.77; CI95%=1.85; 4.15) and preparation stages (OR=1.75; CI95%=1.12; 2.70). Over 60% of technical-administrative servers are insufficiently active (pre-contemplation, contemplation and preparation stages) and factors associated with SBC were female sex and inadequate eating habits.
Incapacidade funcional e fatores associados em idosos de área urbana: um estudo de base populacional
Authors: Tavares Darlene Mara dos Santos , Pelizaro Paula Berteli , Pegorari Maycon Sousa , Paiva Mariana Mapelli de , Marchiori Gianna Fiori 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n5p499 Population aging may cause impaired functional abilities in the elderly population, with increased rates of functional disability. Early detection of functional disability makes it possible to postpone possible complications and helps with health action planning. The objective of this study was to investigate the factors associated with functional disability in urban elderly. We conducted an analytical and cross-sectional household survey with 1,691 urban elderly individuals in Uberaba (MG), Brazil, in 2012. The questionnaire included socioeconomic and clinical information. We used the following instruments to assessed the participants: Abbreviated Geriatric Depression Scale, Katz Index, and Lawton and Brody Scale. We performed a descriptive bivariate analysis and used a logistic regression model (p<0.05). The prevalence of functional disability in basic activities of daily living was 21.2%; whereas the prevalence of functional disability in instrumental activities of daily living was 65.9%. The following factors were associated with functional disability in basic and instrumental activities of daily living, respectively: age of 80 years old and older [(OR= 2.18; p<0.001), (OR=3.30, p<0.001)]; larger number of self-reported diseases [(OR=1.24, p<0.001), (OR=1.12; p<0.001)]; and symptoms of depression [(OR=1.49; p<0.003), (OR = 1.75, p<0.001)]; whereas no schooling (OR=1.88; p<0.001) was related to functional disability in instrumental activities of daily living. We found significant impairment of functional status, especially in instrumental activities of daily living and in association with socioeconomic and health variables; those aspects support the implementation of actions aimed at monitoring and controlling the factors that interfere with the functional ability of the elderly.
Barreiras percebidas à prática de atividades físicas em escolares do ensino médio
Authors: Pandolfo Kelly Christine Maccarini , Minuzzi Tatiane , Machado Rafaella Righes , Lopes Luís Felipe Dias , Azambuja Cati Reckelberg , Santos Daniela Lopes dos 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n5p567 In an attempt to understand the problem of declining physical activity (PA) among adolescents, there has been an increasing interest in identifying perceived barriers (PB) that can reduce the involvement of adolescents in PA. The aim of this study was to identify PB to PA practice among public high school students. The samples was composed of 348 students aged 14-19 years, 46.8% females and 53.2% males. To investigate BP, an instrument consisting of 12 statements and validated for the study population was used. The analysis of results was carried out by descriptive statistics, Kruskal Wallis test to check the possible differences in PB throughout high school years and chi-square for the difference in proportions of barriers. Having many tasks to do, lack of time and adverse weather conditions were the most cited PB. There was no difference in the perception of barriers among high school years (males: p = 0.44; females: p = 0.23). PB “not having how to go or return” (p = 0.04), “adverse weather conditions” and “laziness” (p = 0.02), “lack of time” (p = 0.01) and “at home nobody performs PA” (p = 0.04) showed statistically significant differences between sexes. Both sexes reported similar barriers; however, girls reported higher number of PB and with greater frequency. Identifying which PB prevent the adoption of a physically active lifestyle may be the beginning of solutions to minimize the negative effects.
Gordura corporal e perfil lipídico de gêmeos monozigóticos discordantes para resistência à insulina
Authors: Cavazzotto Timothy Gustavo , Queiroga Marcos Roberto , Ferreira Sandra Aires , Kokubun Eduardo , Bueno Maria Raquel De Oliveira , Serassuelo Junior Helio 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n6p690 The study investigated alterations in body fat and metabolic profile of adolescent monozygotic twins, resulting from discordance for insulin resistance, adjusted for physical activity, physical fitness and heredity. Thirty-eight pairs of monozygotic twins were assessed for anthropometric measurements to estimate body fat. Physical fitness was estimated with treadmill test and use of ergospirometer. Daily physical activity was estimated from the daily count of steps measured by a pedometer during 3 days. Fasting blood samples were used to determine blood glucose, insulin, lipid parameters. The Homa-IR and HOMA-β indexes were calculated. Twins with measures higher than 2.5 were considered insulin resistant. When both brothers were below or above cutoffs, the pair was allocated to the concordant group. When one brother was insulin resistant and the other was not, the pair was allocated in the discordant group. Twins were compared using paired test. In the discordant group, it was observed that insulin-resistant twins had higher birth weight values, bodyweight, BMI, waist circumference, body fat percentage, body fat (sum of skinfolds), Homa-β index and lower HDL compared to their corresponding pair. Insulin-resistant twins showed higher values in anthropometry and body composition, as well as in the glycemia and insulin index and lower HDL. These events may have been unchained by metabolic alterations possibly originating from gestational stage, however, modulated by body composition.
Efeito de duas diferentes frequências semanais de treinamento com pesos sobre a força muscular e pressão arterial em mulheres idosas normotensas
Authors: Silva Renato Galindo da , Silva Danilo Rodrigues Pereira da , Pina Fábio Luiz Cheche , Nascimento Matheus Amarante do , Ribeiro Alex Silva , Cyrino Edilson Serpeloni 
Published: December 2017

DOI: http://dx.doi.org/10.5007/1980-0037.2017v19n1p118 The aim of this study was to analyze the effect of two different weekly resistance training (RT) frequencies on muscle strength and blood pressure (BP) in normotensive older women. Thirty normotensive and physically independent older women participated in the study, which were divided into two groups: RT performed in two weekly sessions (G2X, n = 17; 67.6 ± 4.6 years; 69.7 ± 13.4 kg; 156.6 ± 5.8 cm) and three weekly sessions (G3X; n = 13; 68.7 ± 5.0 years; 69.8 ± 16.1 kg, 155.2 ± 7.8 cm). The RT program was composed by eight exercises for different muscle groups (upper limbs, trunk and lower limbs), lasting 24 weeks (two phases of 12 weeks each). In the first phase, exercises were performed in one set of 10-15 maximum repetitions per exercise, while in the second phase, two sets were performed. BP and muscle strength (1RM) measures were performed at pre-training and after 12 and 24 weeks of RT. Increases in total muscle strength (P < 0.05) were observed in both groups (G2X = 16.8% and G3X = 18.9%), with no difference between groups. On the other hand, no significant changes (P > 0.05) in systolic BP and diastolic BP were found in both groups. The results suggest that 24 weeks of a supervised RT program improve muscle strength without affecting BP in normotensive older women, regardless of frequency of two or three weekly sessions.