bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital curation in museums
Authors: Ray Joyce 
Published: March 2017

Purpose
The purpose of this paper is to present a perspective on the development of digital curation education and practice in museums in the USA.

Design/methodology/approach
Methods used include: a historical overview of the development of digital curation, originally as a field of practice – primarily in the sciences – and then as a field of study; a case study of the adaptation of a digital curation curriculum (DigCCurr) framework developed in schools of library and information science (LIS) to a museum studies program; and a discussion of trends in digital curation practices in museums.

Findings
The case study (the digital curation certificate program of Johns Hopkins University’s museum studies program) describes a successful adaptation of the LIS DigCCurr framework in a museum studies program.

Practical implications
Findings could help to advance the museum field through the integration of digital curation education, practice and research.

Social implications
By adopting and supporting digital curation practices, education and research, museums can reach and engage more online users seeking information about museum collections. More online users may also become onsite visitors.

Originality/value
There is little existing literature on digital curation education in museum studies programs.
Structural, mechanical and elastic properties of Ni0.7−xCoxZn0.3Fe2O4 nano-ferrite thick films
Authors: Rendale Maruti K. , Mathad S.N. , Puri Vijaya 
Published: March 2017

Purpose
The present communication aims to investigate the influence of cobalt substitution on the structural, mechanical and elastic properties of nickel–zinc ferrite thick films. The changes observed in the crystallite size (D), lattice constant (a), texture coefficient [TC(hkl)] and mechanical and elastic properties of the thick films due to cobalt substitution have been reported systematically.

Design/methodology/approach
Ni–Zn ferrites with the stoichiometric formula Ni0.7−xCoxZn0.3Fe2O4 (where, x = 0, 0.04, 0.08, 0.12, 0.16 and 0.20) were synthesized via solution combustion technique using sucrose as the fuel and poly-vinyl-alcohol as the matrix material. The thick films of the ferrites were fabricated on alumina substrates by the screen printing method. The thickness of the films was 25 μm, as measured by the gravimetric method. The thick films were subjected to X-ray diffraction and Fourier transform infrared spectroscopy.

Findings
The detailed study of variation of lattice parameter (a), sintering density, micro-strain and elastic properties with cobalt (Co+2) substituted was carried out. The remarkable increase in lattice parameter (from 8.369 A° to 8.3825 A°), bulk density and average grain size (69-119 nm) with the cobalt content was due to larger ionic radius of Co2+ compared to Ni2+. Texture analysis [TC(hkl)] reveals all thick films have adequate grain growth in the (311) plane direction. The main absorption bands of spinel ferrite have appeared through infrared absorption spectra recorded in the range of 300-700 cm−1.

Originality/value
The variation in stiffness constants (for isotropic material, C11 = C12), longitudinal elastic wave (Vl), transverse elastic wave (Vt), mean elastic velocity (VMean), rigidity modulus (G), Poisson’s ratio(s) and Young’s modulus (E) with cobalt (Co+2) composition has been interpreted in terms of binding forces found.
Growth kinetic and composition of the interfacial layer for RF sputtering Al2O3layer on germanium
Authors: Sahari Siti Kudnie , Kashif Muhammad , Mohamed Sutan Norsuzailina , Embong Zaidi , Nik Zaini Fathi Nik Amni Fathi , Hamzah Azrul Azlan , Sapawi Rohana , Yeop Majlis Burhanuddin , Ahmad Ibrahim 
Published: March 2017

PurposeThe quality of GeOx–Ge interface and the equivalent oxide thickness (EOT) are the main issues in fabricating high-k/Ge gate stack due to the low-k of GeOx interfacial layer (IL). Therefore, a precise study of the formation of GeOx IL and its contribution to EOT is of utmost importance. In this study, the GeOx ILs were formed through post-oxidation annealing of sputtered Al2O3on the Ge substrate. The purpose of this paper is to report on growth kinetics and composition of IL between Al2O3and Ge for HCl- and HF-last Ge surface.Design/methodology/approachAfter wet chemical cleaning with HCl or HF, Al2O3was grown onto the Ge surface by RF sputtering. Thickness and composition of IL formed after post-anneal deposition at 400°C in dry oxygen ambience were evaluated as a function of deposition time by FESEM and characterized by X-ray photoelectron spectroscopy, respectively.FindingsIt was observed that the composition and thickness of IL were dependent on the starting surface and an aluminum germinate-like composition was formed during RF sputtering for both HF- and HCl-last starting surface.Originality/valueThe novelty of this work is to investigate the starting surface of Ge to IL growth between Al2O3/Ge that will lead to the improvement in Ge metal insulator field effect transistors (MISFETs) application.
Programmatic generation of computationally efficient lattice structures for additive manufacture
Authors: McMillan Matthew Leslie , Jurg Marten , Leary Martin , Brandt Milan 
Published: March 2017

Purpose
Additive manufacturing (AM) enables the fabrication of complex geometries beyond the capability of traditional manufacturing methods. Complex lattice structures have enabled engineering innovation; however, the use of traditional computer-aided design (CAD) methods for the generation of lattice structures is inefficient, time-consuming and can present challenges to process integration. In an effort to improve the implementation of lattice structures into engineering applications, this paper aims to develop a programmatic lattice generator (PLG).

Design/methodology/approach
The PLG method is computationally efficient; has direct control over the quality of the stereolithographic (STL) file produced; enables the generation of more complex lattice than traditional methods; is fully programmatic, allowing batch generation and interfacing with process integration and design optimization tools; capable of generating a lattice STL file from a generic input file of node and connectivity data; and can export a beam model for numerical analysis.

Findings
This method has been successfully implemented in the generation of uniform, radial and space filling lattices. Case studies were developed which showed a reduction in processing time greater than 60 per cent for a 3,375 cell lattice over traditional CAD software.

Originality/value
The PLG method is a novel design for additive manufacture (DFAM) tool with unique advantages, including full control over the number of facets that represent a lattice strut, allowing optimization of STL data to minimize file size, while maintaining suitable resolution for the implemented AM process; programmatic DFAM capability that overcomes the learning curve of traditional CAD when producing complex lattice structures, therefore is independent of designer proficiency and compatible with process integration; and the capability to output both STL files and associated data for numerical analysis, a unique DFAM capability not previously reported.
Direct 3D printing of low melting point alloy via adhesion mechanism
Authors: Yu Yongze , Liu Fujun , Liu Jing 
Published: March 2017

PurposeThis paper aims to propose a method that can directly print low-melting-point alloy In61Bi26Sn9Ga4 into a variety of macroscopic 3D structures at room temperature via adhesion mechanism.Design/methodology/approachIn the first section, the principle of the direct printing system is described. As process parameters and material properties have both geometric and physical significance to printing, the approach the authors take is to study the relationships between key parameters and ultimate printed dimension. The surface tension of the fusible alloy is measured under different temperature ranges.FindingsThe interaction between the initial standoff distance and the geometry of the first layer is critically important for the adhesion of the liquid metal to the substrate and metal deposition. The characterization of the layer stacking in the direct printing process, stability ranges of the layer thickness and printing speed are also demonstrated. The direct printing system is suitable for making 3D structures with low-melting-point alloy under the summarized range of printing conditions.Social implicationsThis study may arouse big public attention among society.Originality/valueThis study shows possibilities of manufacturing macroscopic 3D metal objects by continuously depositing molten alloy with low viscosity and high surface tension around room temperature. This study provides a supplement to realize compound printing with metal and nonmetal materials together for building terminal functional devices in a low cost and efficient way.
The cardiac L‐type calcium channel alpha subunit is a target for direct redox modification during oxidative stress—the role of cysteine residues in the alpha interacting domain
Authors: Muralidharan Padmapriya , Cserne Szappanos Henrietta , Ingley Evan , Hool Livia C 
Published: March 2017

SummaryCardiovascular disease is the leading cause of death in the Western world. The incidence of cardiovascular disease is predicted to further rise with the increase in obesity and diabetes and with the aging population. Even though the survival rate from ischaemic heart disease has improved over the past 30 years, many patients progress to a chronic pathological condition, known as cardiac hypertrophy that is associated with an increase in morbidity and mortality. Reactive oxygen species (ROS) and calcium play an essential role in mediating cardiac hypertrophy. The L‐type calcium channel is the main route for calcium influx into cardiac myocytes. There is now good evidence for a direct role for the L‐type calcium channel in the development of cardiac hypertrophy. Cysteines on the channel are targets for redox modification and glutathionylation of the channel can modulate the function of the channel protein leading to the onset of pathology. The cysteine responsible for modification of L‐type calcium channel function has now been identified. Detailed understanding of the role of cysteines as possible targets during oxidative stress may assist in designing therapy to prevent the development of hypertrophy and heart failure.
The ‘fiver’: Germanic ‘finger’, Balto‐Slavic de‐numeral adjectives in *‐ero‐ and their Indo‐European background
Authors: Majer Marek 
Published: March 2017

AbstractProto‐Germanic *fingraz ‘finger’ – long connected to PIE *penkʷe ‘5’, but without a convincing derivational scenario – can be interpreted as *pēnkʷ‐ró‐, a genitival R(V̄)‐ó‐ vr̥ddhi derivative to *penkʷerom ‘set of 5’. This latter form is the substantivization of *penkʷero‐ ‘5‐fold, counting 5’ – a form belonging to a series of de‐numeral adjectives which, it is argued, is the single type underlying the Baltic pluralia tantum numerals (Lith. penkerì ‘5.pl.tant’) and the Slavic collectives and distributives (PSl. *pętero ‘group of 5’, *pęterъ ‘5‐fold’). It is further hypothesized that (Post‐)PIE forms like *penkwero‐, *sweḱsero‐, *septm̥mero‐ need not rest upon false segmentation of a thematic derivative of ‘4’ (*kwetwer‐o‐), as is most commonly assumed; rather, they can be explained as simple thematic derivatives of an *‐er locative of the type *penkʷer ‘in/on/at 5’ = ‘in a group of 5’ (a close parallel of this semantic relationship is provided by Lith. arch. trisù ‘3.loc’ = ‘in a group of 3’, or even by French à trois). The posited type *penkʷer also yields a back‐formed substantive *penkʷōr ‘set of 5‐s’, a possible source of the Tocharian B distributive numerals in ‐ār (piśār ‘by 5‐s’ << *penkʷōr‐en, *penkʷōr‐i or similar), which – being athematic – cannot be explained via the standard theory starting from *kʷetwer‐o‐.
Energy Drink Induced Lipid Peroxidation and Oxidative Damage in Rat Liver and Brain When Used Alone or Combined with Alcohol
Authors: Reis Rengin , Charehsaz Mohammad , Sipahi Hande , Ekici Asiye Işın Doğan , Macit Çağlar , Akkaya Hatice , Aydın Ahmet 
Published: March 2017

AbstractEnergy drinks (ED) are containing large doses of metabolic stimulants and its use with ethanol has increased dramatically among young adults. In this study, we examined the effects of ED exposure either alone or in combination with ethanol on oxidative stress parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH‐Px), and lipid peroxidation parameter malondialdehyde (MDA) in rat. Some histopathological findings were also evaluated. ED exposure led to a dose‐dependent increase in liver MDA compared to the control indicating oxidative damage. Histopathological findings also revealed that ED alone may generate liver damage. Ethanol exposure increased MDA level and SOD, CAT, and GSH‐Px activity in both the brain and the liver. The combination of ethanol and ED produced greater damage which is considered by further increases in SOD and GSH‐Px activity in the brain. Similar results for MDA were observed in both the liver and brain as well. Our findings suggest that ED consumption alone or combination with ethanol may represent a significant public health concern.
Serum adipocyte fatty acid‐binding protein levels are associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus
Authors: Ding Min , Shi Jian‐Ying , XING Yun‐Zhi , Sun Bei , Fang Qian‐Hua , Zhang Jing‐Yun , Zhang Qiu‐Mei , Chen Li‐Ming , Yu De‐min , Li Chun‐Jun 
Published: March 2017

AbstractBackgroundAdipocyte fatty acid‐binding protein (A‐FABP) has been recognized as an important player in macrophage cholesterol trafficking and inflammation, and may promote the development of atherosclerosis. To further elucidate the role of A‐FABP in atherosclerosis in diabetes, we investigated the relationship between serum A‐FABP concentrations and peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM).MethodsIn all, 488 inpatients with T2DM were enrolled in the study (254 men, 234 women; mean (±SD) age 57.3 ± 13.0 years). The severity of peripheral arterial stenosis was assessed by ultrasound examination. Serum A‐FABP concentrations were determined by ELISA.ResultsSerum A‐FABP concentrations were significantly higher in patients with than without PAD (8.0 ± 3.3 vs 6.2 ± 1.6 ng/mL, respectively; P < 0.05). Interestingly, there was an obvious gender‐related difference in PAD patients with T2DM, with the stenosis rate being higher for female than male T2DM patients in the third A‐FABP tertile. Logistic regression analysis revealed that serum A‐FABP concentrations were an independent risk factor for PAD in female T2DM patients (odds ratio 1.890, 95% confidence interval 1.041–3.432; P = 0.036), but not in male T2DM patients. Correlation analyses revealed that A‐FABP concentrations were correlated with body mass index (BMI), diastolic blood pressure, urinary microalbumin, and serum creatinine in male patients, and with BMI, duration of T2DM, fasting blood glucose, and serum creatinine in female patients.ConclusionsSerum A‐FABP concentrations are closely associated with PAD in Chinese women with T2DM. The study findings suggest that A‐FABP may be a more specific marker of PAD in diabetic women than men.
Efficacy and safety of weekly intravenous nanoparticle albumin‐bound paclitaxel for non‐small cell lung cancer patients who have failed at least two prior systemic treatments
Authors: Duan Jianchun , Hao Yueqin , Wan Rui , Yu Sifan , Bai Hua , An Tongtong , Zhao Jun , Wang Zhijie , Zhuo Minglei , Wang Jie 
Published: March 2017

BackgroundThe study was conducted to evaluate the efficacy and safety of weekly intravenous nanoparticle albumin‐bound paclitaxel (NAB‐paclitaxel) treatment in patients with advanced non‐small‐cell lung cancer (NSCLC) who have undergone multi‐line therapy, and to investigate the association of secreted protein acidic and rich in cysteine (SPARC) expression status with clinical outcome.MethodsSixty‐four patients who received NAB‐paclitaxel treatment (130 mg/m2 on days 1 and 8 of a 21 day cycle) as third line or further systemic treatment from 1 May 2011 to 30 June 2014 were included in this retrospective analysis. Tumor tissue was available in 28 patients for analysis of SPARC expression by immunohistochemistry.ResultsSixty‐two patients had response evaluation and complete survival follow‐up data; 83.9% received the weekly NAB‐paclitaxel as fourth‐line treatment or beyond. The objective response and disease control rates (n = 62) were 16.1% (10/62) and 64.5% (40/62), respectively. The median progression‐free and overall survival rates were 3.7 (95% confidence interval 2.6–4.8) and 9.8 months (95% confidence interval 6.9–12.8), respectively. Previous treatment with taxane did not affect the response to NAB‐paclitaxel. The main grade 3–4 toxicities experienced were neutropenia (9.4%) and leukopenia (7.8%). Patients with SPARC expression in tumor stroma but not in cancer cells had poorer progression‐free survival compared with those with negative SPARC expression in tumor stroma cells (3.3 vs. 5.0 months, P = 0.036).ConclusionWeekly NAB‐paclitaxel might be effective for heavily pretreated NSCLC patients. SPARC expression in tumor stroma cells might be a potential negative predictor of NAB‐paclitaxel.
Long lasting effects of chronic heavy cannabis abuse
Authors: Nestoros Joannis N. , Vakonaki Elena , Tzatzarakis Manolis N. , Alegakis Athanasios , Skondras Markos D. , Tsatsakis Aristidis M. 
Published: March 2017

Background and ObjectivesThe purpose of this study was to evaluate the extent of short‐term memory impairment and schizophrenia‐like symptoms in heavy and systematic cannabis users and the association between the severity of abuse and the longevity of its persistent symptoms after refraining from such use.MethodsA complete psychiatric examination and a psychometric evaluation were performed in 48 solely cannabis users. Additionally, head hair samples were analyzed and the detected cannabinoids levels were correlated with the psychometric findings.ResultsA total of 33.3% (n = 16) of the total examined cannabis users were currently imprisoned. The years of abuse ranged from 1 to 35 years and the median daily dose was 5.84.4 gr and 4.84.0 gr for prisoners (n = 16) and non prisoners (n = 32), respectively. A total of 39.6% of the users experienced hallucinations (mostly auditory), 54.2% experienced delusions (mostly ideas of reference and persecution), 85.4% had organic brain dysfunction in a test addressing visual‐motor functioning and visual perception skills, and all users (100%) were found to have organic brain dysfunction in a test of visual memory immediate recall. The cannabinoid metabolite levels in the hair samples were consistent with the reported history of substance abuse and total grams of consumption for the participants below 35 years old (p < .001). Statistically elevated cannabinoids levels were observed in users with auditory hallucinations compared to users without any hallucinations (p = .019).ConclusionsThe existence of hallucinations, delusions, and organic brain dysfunction in heavy cannabis users seems to be associated with cannabinoid levels in hair. The continuation of persistent symptoms 3 months after the discontinuation of cannabis abuse, was a remarkable finding.Scientific SignificanceWe provide evidence that chronic and heavy cannabis abuse results in long‐lasting brain dysfunction in all users and in long‐lasting schizophrenia‐like psychotic symptoms in more than half of all users. These findings suggest a reevaluation of the current classification of cannabis as a “soft narcotic” which erroneously, therefore, is typically considered harmless. (Am J Addict 2017;26:335–342)
Quality of life on TSU‐68: Combination of docetaxel and TSU‐68, an oral antiangiogenic agent, in patients with metastatic breast cancer previously treated with anthracycline
Authors: Sohn Byeong Seok , Kim Sung‐Bae , Ahn Jin‐Hee , Jung Kyung Hae , Kim Jeongeun , Lee Keun Seok , Ro Jungsil , Im Seock‐Ah , Im Young‐Hyuck , Song Hong Suk , Park Hee Sook , Chung Hyun‐Cheol 
Published: March 2017

AbstractAimThe aim of this study is to investigate whether the addition of TSU‐68 would affect on the quality of life (QOL) of Korean metastatic breast cancer patients treated with docetaxel.MethodsSixty‐three of 78 patients completed the baseline QOL questionnaires and at least one follow‐up questionnaire comprising questions from the Korean Functional Assessment of Cancer Therapy–Breast (FACT‐B), hospital anxiety and depression scale (HAD), the shortened form of the profile of mood states (BPOMS), and anticipation and anxiety for treatment scale. Changes in QOL scores from baseline were compared by analysis of covariance at each time point (6, 12 weeks, 9, 12 and 18 months) and at the end of treatment (EOT), and the longitudinal changes over time were evaluated by repeated measure analysis.ResultsThe two‐treatment groups (TSU‐68 plus docetaxel [A] vs docetaxel alone [B]) were well balanced regarding sociodemographic characteristics, including age (P = 0.450), religion (P = 1.000), education (P = 0.257), ECOG performance status (P = 0.261), and employment status (P = 0.325). The return rate at EOT was 61.9%. In analyses at each QOL measuring time, A group showed a higher FACT‐B total score and FACT‐G score than B at 12 months (P = 0.031 and P = 0.024, respectively). The anticipation and anxiety for treatment scale of A group was higher than that of B at 12 weeks and EOT (P = 0.046 and P = 0.022, respectively). However, repeated measure analysis for longitudinal changes over time showed no significant group wise differences.ConclusionsThe combination of TSU‐68 with docetaxel showed no additional adverse effects on patient QOL during the study period, as compared with docetaxel monotherapy.
Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA‐ARIA‐EPOS‐AIRWAYS ICP statement
Authors: Hellings P. W. , Fokkens W. J. , Bachert C. , Akdis C. A. , Bieber T. , Agache I. , Bernal‐Sprekelsen M. , Canonica G. W. , Gevaert P. , Joos G. , Lund V. , Muraro A. , Onerci M. , Zuberbier T. , Pugin B. , Seys S. F. , Bousquet J. ,   ARIA and EPOS working groups
Published: March 2017

AbstractPrecision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second‐level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long‐term therapeutic strategy. Endotype‐driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment.