bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line–Specific Effects from P-Glycoprotein–Induced Toxicity
Authors: Füredi András , Tóth Szilárd , Szebényi Kornélia , Pape Veronika F.S. , Türk Dóra , Kucsma Nóra , Cervenak László , Tóvári József , Szakács Gergely 
Published: October 2016

Abstract
Despite significant progress, resistance to chemotherapy is still the main reason why cancer remains a deadly disease. An attractive strategy is to target the collateral sensitivity of otherwise multidrug resistant (MDR) cancer. In this study, our aim was to catalog various compounds that were reported to elicit increased toxicity in P-glycoprotein (Pgp)–overexpressing MDR cells. We show that the activity of most of the serendipitously identified compounds reported to target MDR cells is in fact cell-line specific, and is not influenced significantly by the function of Pgp. In contrast, novel 8-hydroxyquinoline derivatives that we identify in the National Cancer Institute (NCI) drug repository possess a robust Pgp-dependent toxic activity across diverse cell lines. Pgp expression associated with the resistance of the doxorubicin-resistant Brca1−/−;p53−/− spontaneous mouse mammary carcinoma cells could be eliminated by a single treatment with NSC57969, suggesting that MDR-selective compounds can effectively revert the MDR phenotype of cells expressing Pgp at clinically relevant levels. The discovery of new MDR-selective compounds shows the potential of this emerging technology and highlights the 8-hydroxyquinoline scaffold as a promising starting point for the development of compounds targeting the Achilles heel of drug-resistant cancer. Mol Cancer Ther; 16(1); 45–56. ©2016 AACR.
Selective Interareal Synchronization through Gamma Frequency Differences and Slower-Rhythm Gamma Phase Reset
Authors: Burwick Thomas , Bouras Alexandros 
Published: October 2016

The communication-through-coherence (CTC) hypothesis states that a sending group of neurons will have a particularly strong effect on a receiving group if both groups oscillate in a phase-locked (“coherent”) manner (Fries, 2005 , 2015 ). Here, we consider a situation with two visual stimuli, one in the focus of attention and the other distracting, resulting in two sites of excitation at an early cortical area that project to a common site in a next area. Taking a modeler’s perspective, we confirm the workings of a mechanism that was proposed by Bosman et al. ( 2012 ) in the context of providing experimental evidence for the CTC hypothesis: a slightly higher gamma frequency of the attended sending site compared to the distracting site may cause selective interareal synchronization with the receiving site if combined with a slow-rhythm gamma phase reset. We also demonstrate the relevance of a slightly lower intrinsic frequency of the receiving site for this scenario. Moreover, we discuss conditions for a transition from bottom-up to top-down driven phase locking.
Diurnal Variations of Presummer Rainfall over Southern China
Authors: Jiang Zhina , Zhang Da-Lin , Xia Rudi , Qian Tingting 
Published: October 2016

AbstractIn this study, the presummer diurnal cycle of rainfall (DCR) over southern China is examined using the merged 0.1°-resolution gridded hourly rain gauge and satellite rainfall dataset and the National Centers for Environmental Prediction Final Global Analysis during April to June of 2008–2015. Results show pronounced diurnal variations in rainfall amount, frequency, and intensity over southern China, with substantially different amplitudes from southwestern to southeastern China, and from the pre- to postmonsoon-onset period. Southwestern China often encounters significant nocturnal-to-morning rainfall under the influence of enhanced nocturnal low-level southwesterly winds. Southeastern China is dominated by afternoon rainfall, as a result of surface heating, likely aided by local topographical lifting. Both the pre- and postmonsoon-onset periods exhibit two diurnal rainfall peaks: one in the early morning and the other in the late afternoon. But the latter shows the two peaks with nearly equal amplitude whereas the former displays a much larger early morning peak than that in the late afternoon. Three propagating modes accounting for the presummer DCR are found: (i) an eastward- or southeastward-propagating mode occurs mostly over southwestern China that is associated with enhanced transport of warm and moist air from tropical origin and the induced low-level convergence, (ii) a quasi-stationary mode over southeastern China appears locally in the warm sector with weak-gradient flows, and (iii) an inland-propagating mode occurs during the daytime in association with sea breezes along the southern coastal regions, especially evident throughout the postmonsoon-onset period.
Structural and Environmental Characteristics of Extratropical Cyclones Associated with Tornado Outbreaks in the Warm Sector: An Idealized Numerical Study
Authors: Tochimoto Eigo , Niino Hiroshi 
Published: October 2016

Abstract
To clarify the effects of the horizontal shear of the jet stream on the structure and environment of extratropical cyclones that are accompanied by tornado outbreaks (OCs) and those that are not (NOCs), two idealized numerical experiments are performed. The experiments (OC-CTL and NOC-CTL) adopt the basic states taken from the corresponding composites of reanalysis data (JRA-55), except that the humidity field in both cases is taken from the OC composite.
The simulated cyclone in OC-CTL exhibits a more meridionally elongated structure and stronger low-level wind in the southeast quadrant of the cyclone center, resulting in larger values of storm relative environmental helicity (SREH) than those in NOC-CTL. These results are consistent with the characteristics of the cyclones found for OCs and NOCs in the authors’ composite study. The distributions of surface-based convective available potential energy (SBCAPE) show no notable differences between OC-CTL and NOC-CTL, while those of CAPE based on the most unstable air parcel (MUCAPE) show some differences.
A sensitivity experiment without moist processes such as condensation heating and evaporative cooling shows that the differences in the cyclone structure and environmental parameters between OCs and NOCs can be qualitatively explained by the dry dynamics. However, inclusion of moist processes results in notably larger differences.
High Risk Behaviors but Low Injury-Related Mortality Among Hispanic Teens in Missouri
Authors: Yun Shumei , Kayani Noaman , Geiger Sarah , Homan Sherri , Wilson Janet 
Published: October 2016

Objective: Our objective was to examine racial/ethnic disparities in injury-related risk behaviors and deaths among teens in Missouri, with a focus on Hispanic people—the fastest-growing racial/ethnic group in the state. Methods: We used data from the 2013 Missouri Youth Risk Behavior Survey, which included 1616 students in grades 9 through 12 from 32 public and charter high schools. The overall response rate was 69%. We compared the prevalence of 10 injury-related risk behaviors among racial/ethnic groups and used multivariate logistic regression models to control for respondent age and sex. Using data from the 2000-2014 Missouri death records, we also compared injury-related death rates among racial/ethnic groups of teens aged 15 to 19 years. Results: Hispanic students had a significantly higher prevalence than non-Hispanic white students for 9 of 10 risk behaviors and a significantly higher prevalence than non-Hispanic black students for 6 of the 10 risk behaviors included in the study. However, Hispanic teens aged 15 to 19 years had a significantly lower death rate from suicide, homicide, and unintentional injury combined (39.8 per 100000 population, 95% confidence interval [CI], 32.2-48.5) when compared with their non-Hispanic white (54.3 per 100000 population, 95% CI, 52.3-54.6) or non-Hispanic black (94.1 per 100000 population, 95% CI, 87.9-100.3) counterparts. Conclusion: Injury-related risk behaviors were more prevalent among Hispanic students than non-Hispanic white or non-Hispanic black students. Further efforts are needed to understand risk behaviors among Hispanic teens to guide intervention efforts.
VA Suicide Prevention Applications Network
Authors: Hoffmire Claire , Stephens Brady , Morley Sybil , Thompson Caitlin , Kemp Janet , Bossarte Robert M. 
Published: October 2016

Objectives: The US Department of Veterans Affairs’ Suicide Prevention Applications Network (SPAN) is a national system for suicide event tracking and case management. The objective of this study was to assess data on suicide attempts among people using Veterans Health Administration (VHA) services. Methods: We assessed the degree of data overlap on suicide attempters reported in SPAN and the VHA’s medical records from October 1, 2010, to September 30, 2014—overall, by year, and by region. Data on suicide attempters in the VHA’s medical records consisted of diagnoses documented with E95 codes from the International Classification of Diseases, Ninth Revision. Results: Of 50 518 VHA patients who attempted suicide during the 4-year study period, data on fewer than half (41%) were reported in both SPAN and the medical records; nearly 65% of patients whose suicide attempt was recorded in SPAN had no data on attempted suicide in the VHA’s medical records. Conclusion: Evaluation of administrative data suggests that use of SPAN substantially increases the collection of data on suicide attempters as compared with the use of medical records alone, but neither SPAN nor the VHA’s medical records identify all suicide attempters. Further research is needed to better understand the strengths and limitations of both systems and how to best combine information across systems.
An Empirical Study of Design Parameters for Assessing Differential Impacts for Students in Group Randomized Trials
Authors: Jaciw Andrew P. , Lin Li , Ma Boya 
Published: October 2016

Background: Prior research has investigated design parameters for assessing average program impacts on achievement outcomes with cluster randomized trials (CRTs). Less is known about parameters important for assessing differential impacts. Objectives: This article develops a statistical framework for designing CRTs to assess differences in impact among student subgroups and presents initial estimates of critical parameters. Research design: Effect sizes and minimum detectable effect sizes for average and differential impacts are calculated before and after conditioning on effects of covariates using results from several CRTs. Relative sensitivities to detect average and differential impacts are also examined. Subjects: Student outcomes from six CRTs are analyzed. Measures: Achievement in math, science, reading, and writing. Results: The ratio of between-cluster variation in the slope of the moderator divided by total variance—the “moderator gap variance ratio”—is important for designing studies to detect differences in impact between student subgroups. This quantity is the analogue of the intraclass correlation coefficient. Typical values were .02 for gender and .04 for socioeconomic status. For studies considered, in many cases estimates of differential impact were larger than of average impact, and after conditioning on effects of covariates, similar power was achieved for detecting average and differential impacts of the same size. Conclusions: Measuring differential impacts is important for addressing questions of equity, generalizability, and guiding interpretation of subgroup impact findings. Adequate power for doing this is in some cases reachable with CRTs designed to measure average impacts. Continuing collection of parameters for assessing differential impacts is the next step.
The diagnostic value of multimodality MRI in endometrial carcinoma staging
Authors: Du Lixin , Yu Yongqiang , Wang Yuli , Xia Jun , Qiu Xixiong , Lei Yi 
Published: October 2016

Background Multimodality magnetic resonance imaging (MRI) is an imaging technology that is used to integrate the structural and functional information of lesions. MRI can determine the staging of endometrial carcinoma, provide guidance for selection of surgical treatment and postoperative prognostic assessment, and has an important role in improving the survival of patients with endometrial carcinoma. Purpose To evaluate multimodality MRI staging accuracy for endometrial carcinoma based on the International Federation of Gynecology and Obstetrics (FIGO 2009) staging system. Material and Methods This is a retrospective study of the complete clinical and surgical pathology data from 83 patients with endometrial carcinoma treated between June 2011 and August 2015. Using a blind design, the preoperative clinical staging according to the current FIGO2009 MRI-based staging for each endometrial carcinoma was analyzed and corrected by postoperative histopathological results, which served as the staging standard. The role of multimodality MRI on clinical staging accuracy for endometrial carcinoma was studied. Results Based on the pathological evaluation after surgery, the 83 endometrial carcinoma patients were staged according to the current FIGO2009 staging criteria as: stage I, n = 56; stage II, n = 17; stage III, n = 7; and stage IV, n = 3. The multimodality MRI staging accuracy for endometrial carcinoma stages I–IV by FIGO2009 were 91.6% (76/83), 91.6% (76/83), 92.8% (77/83), and 97.6% (81/83), respectively. Conclusion Multimodality MRI is an important imaging tool in the pre-operative clinical staging of endometrial carcinoma. The current FIGO staging system appears to be a concise, reasonable, and practical set of criteria for the clinical management of endometrial carcinoma.
Prasugrel versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms
Authors: Sedat Jacques , Chau Yves , Gaudart Jean , Sachet Marina , Beuil Stephanie , Lonjon Michel 
Published: October 2016

Background Thromboembolic complications are the main problem in stent-assisted coil embolization of unruptured intracranial aneurysms. The combination of aspirin and clopidogrel is generally used to decrease these complications, but some patients do not respond to clopidogrel and have a higher risk of stent thrombosis. In cardiology, clinical trials have shown that prasugrel reduced the incidence of ischaemic events in patients with acute coronary syndrome compared with clopidogrel but, according to several authors, prasugrel would produce an increased risk of cerebral haemorrhagic complications. Objective The purpose of this study was to determine whether prasugrel would be more effective than clopidogrel in reducing procedural events in patients with an unruptured aneurysm treated endovascularly with coils and stent. Materials and methods Two hundred consecutive patients with intracranial aneurysms were treated using coiling and stenting procedures. The first 100 patients were administered a dual antiplatelet of aspirin and clopidogrel, while the remaining 100 patients were administered a dual antiplatelet of aspirin and prasugrel. In each group data were collected on procedural and periprocedural haemorrhagic and ischaemic complications. Results Aneurysmal occlusion and haemorrhagic complications rates were identical in both groups. The number of thromboembolic events observed in the two groups of our study did not differ significantly, but the prasugrel group included more wide-neck aneurysms and more flow-diverted stents. Moreover, complications in the prasugrel group were more benign, explaining the significant difference in clinical outcomes between the two groups on Day 30. Conclusions Prasugrel reduces the clinical consequences of thromboembolic complications of endovascular treatment with stenting and coiling of unruptured intracranial aneurysms.
Optimal biliary access point and learning curve for endoscopic ultrasound-guided hepaticogastrostomy with transmural stenting
Authors: Oh Dongwook , Park Do Hyun , Song Tae Jun , Lee Sang Soo , Seo Dong-Wan , Lee Sung Koo , Kim Myung-Hwan 
Published: October 2016

Background: Although endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) with transmural stenting has increased for biliary decompression in patients with an inaccessible papilla, the optimal biliary access point and the learning curve of EUS-HGS have not been studied. We evaluated the optimal biliary access point and learning curve for technically successful EUS-HGS. Methods: 129 consecutive patients (male n = 81, 62.3%; malignant n = 113, 87.6%) who underwent EUS-HGS due to an inaccessible papilla were enrolled. EUS finding and procedure times according to each needle puncture attempt in EUS-HGS were prospectively measured. Learning curves of EUS-HGS were calculated for two main outcome measurements (procedure time and adverse events) by using the moving average method and cumulative sum (CUSUM) analysis, respectively. Results: A total of 174 EUS-HGS attempts were performed in 129 patients. The mean number of needle punctures was 1.35 ± 0.57. Using the logistic regression model, bile duct diameter of the puncture site ⩽ 5 mm [odds ratio (OR) 3.7, 95% confidence interval (CI): 1.71–8.1, p < 0.01] and hepatic portion length [linear distance from the mural wall to the punctured bile duct wall on EUS; mean hepatic portion length was 27 mm (range 10–47 mm)] > 3 cm (OR 5.7, 95% CI: 2.7–12, p < 0.01) were associated with low technical success. Procedure time and adverse events were shorter after 24 cases, and stabilized at 33 cases of EUS-HGS, respectively. Conclusions: Our data suggest that a bile duct diameter > 5 mm and hepatic portion length 1 cm to ⩽ 3 cm on EUS may be suitable for successful EUS-HGS. In our learning curve analysis, over 33 cases might be required to achieve the plateau phase for successful EUS-HGS.
Adrenocorticotropic hormone versus methylprednisolone added to interferon β in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial
Authors: Berkovich Regina , Bakshi Rohit , Amezcua Lilyana , Axtell Robert C. , Cen Steven Y. , Tauhid Shahamat , Neema Mohit , Steinman Lawrence 
Published: October 2016

Background: The objective of this study was to evaluate monthly intramuscular adrenocorticotropic hormone (ACTH) gel versus intravenous methylprednisolone (IVMP) add-on therapy to interferon β for breakthrough disease in patients with relapsing forms of multiple sclerosis. Methods: This was a prospective, open-label, examiner-blinded, 15-month pilot study evaluating patients with Expanded Disability Status Scale (EDSS) score 3.0–6.5 and at least one clinical relapse or new T2 or gadolinium-enhanced lesion in the previous year. Twenty-three patients were randomized to ACTH ( n = 12) or IVMP ( n = 11) and completed the study. The primary outcome measure was the cumulative number of relapses. Secondary outcomes included EDSS, Mental Health Inventory (MHI), plasma cytokines, MS Functional Composite (MSFC), Quality-of-Life (MS-QOL) score, bone mineral density (BMD), and new or worsened psychiatric symptoms per month. Brain magnetic resonance imaging was analyzed post hoc. This was a preliminary and small-scale study. Results: Relapse rates differed significantly [ACTH 0.08, 95% confidence interval (CI) 0.01–0.54 versus IVMP 0.80, 95% CI 0.36–1.75; rate ratio, IVMP versus ACTH: 9.56, 95% CI 1.23–74.6; p = 0.03]. ACTH improved ( p = 0.03) MHI (slope 0.95 ± 0.38 points/month; p = 0.02 versus slope −0.38 ± 0.43 points/month; p = 0.39). On-study decreases (all p < 0.05) in eight cytokine levels occurred only in the ACTH group. However, on-study EDSS, MSFC, MS-QOL, BMD, and MRI lesion changes were not significant between groups. Psychiatric symptoms per patient were greater with IVMP than ACTH (0.55, 95% CI 0.12–2.6 versus 0; p < 0.0001). Other common adverse events were insomnia and urinary tract infections (IVMP, seven events each) and fatigue or flu symptoms (ACTH, five events each). Conclusions: This study provided class II evidence that ACTH produced better examiner-assessed cumulative rates of relapses per patient than IVMP in the adjunctive treatment of breakthrough disease in multiple sclerosis.
Many Neurology Readmissions Are Nonpreventable
Authors: Le Sidney T. , Josephson S. Andrew , Puttgen Hans A. , Gibson Lorrie , Guterman Elan L. , Leicester Heather M. , Graf Carla L. , Probasco John C. 
Published: October 2016

Introduction: Reducing unplanned hospital readmissions has become a national focus due to the Centers for Medicare and Medicaid Services’ (CMS) penalties for hospitals with high rates. A first step in reducing unplanned readmission is to understand which patients are at high risk for readmission, which readmissions are planned, and how well planned readmissions are currently captured in comparison to patient-level chart review. Methods: We examined all 5455 inpatient neurology admissions over a 2-year period to University of California San Francisco Medical Center and Johns Hopkins Hospital via chart review. We collected information such as patient age, procedure codes, diagnosis codes, all-payer diagnosis-related group, observed length of stay (oLOS), and expected length of stay. We performed multivariate logistic modeling to determine predictors of readmission. Discharge summaries were reviewed for evidence that a subsequent readmission was planned. Results: A total of 353 (6.5%) discharges were readmitted within 30 days. Fifty-five (15.6%) of the 353 readmissions were planned, most often for a neurosurgical procedure (41.8%) or immunotherapy (23.6%). Only 8 of these readmissions would have been classified as planned using current CMS methodology. Patient age (odds ratio [OR] = 1.01 for each 10-year increase, P < .001) and estimated length of stay (OR = 1.04, P = .002) were associated with a greater likelihood of readmission, whereas index admission oLOS was not. Conclusions: Many neurologic readmissions are planned; however, these are often classified by current CMS methodology as unplanned and penalized accordingly. Modifications of the CMS lists for potentially planned neurological and neurosurgical procedures and for acute discharge neurologic diagnoses should be considered.
Early histological findings may predict the clinical phenotype in Crohn’s colitis
Authors: Klein Amir , Mazor Yoav , Karban Amir , Ben‐Itzhak Ofer , Chowers Yehuda , Sabo Edmond 
Published: October 2016

Background and aimsPredicting the clinical course of Crohn’s disease (CD) is relevant for treatment selection. Currently, such diagnostic tools are lacking. In a previous pilot study, morphometric tissue image analysis showed promise in predicting the clinical phenotype and need for surgery. In this study, we aimed to validate our previous results on a larger cohort.MethodsColonic biopsies from CD patients with colonic or ileocolonic disease and at least five years of post‐biopsy clinical follow‐up were analyzed. The results were used to predict post‐biopsy clinical phenotypes and outcomes. Data analysis was performed using multivariate regression models, discriminant score (DS) computations and Neural Network (NNET).ResultsMultivariate analysis of morphometric variables differentiated between B1 and B2 phenotypes (sensitivity 81%, specificity 74%, accuracy on cross‐validation 75%; area under the curve (AUC) of 0.74 (CI 0.6–0.84; NNET model sensitivity 87%, specificity 67% on the testing population)). Differentiation between B1 and B3 phenotypes was also possible (sensitivity 69%, specificity 76%, accuracy 70.5% on cross‐validation; AUC 0.78 (CI 0.68–0.89); NNET model sensitivity 78%, specificity 77% on the testing population)). Differentiating between B2 and B3 phenotypes was not possible using morphometric variables. Multivariate analysis predicted surgery (sensitivity 67%, specificity 72.5%, accuracy 69%; AUC 0.72 (CI 0.61–0.82); NNET model sensitivity 80%, specificity 91% on the testing population)).ConclusionsThis study validates previous results and suggests that morphometric image analysis of early biopsies from Crohn’s colitis patients may contribute to the prediction of future outcomes such as clinical phenotype and surgery. Prospective validation on larger cohorts is still needed.