bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early taxane exposure and neurotoxicity in breast cancer patients
Authors: Cimbro Erika , Dessì Mariele , Ziranu Pina , Madeddu Clelia , Atzori Francesco , Lai Eleonora , Pretta Andrea , Mariani Stefano , Donisi Clelia , Spanu Dario , Pozzari Marta , Murgia Sara , Saba Giorgio , Codipietro Claudia , Palmas Enrico , Sanna Giorgia , Semonella Francesca , Sardo Salvatore , Finco Gabriele , Scartozzi Mario 
Published: October 2024

Abstract
Introduction
Breast cancer is the most diagnosed tumor and a leading cause of cancer death in women worldwide. Taxanes are the most used chemotherapeutic agents and are strictly connected to neurotoxicity. Taxane-induced neuropathy (TIN) significantly impacts patients’ quality of life (QOL). Early identification and management of TIN could improve preventive strategies to preserve patients’ QOL during and after breast cancer treatment.

Objective
This prospective, observational study aimed to evaluate the taxane-induced neuropathy (TIN) in early breast cancer patients treated with weekly paclitaxel at an earlier stage and identify any correlation between TIN and QOL.

Methods
Data from stage I-III breast cancer patients treated with taxane-based therapy between 2018 and 2022 were collected at the Medical Oncology Unit of the University Hospital of Cagliari. Peripheral neuropathy was evaluated using the NCI-CTCAE scale (National Cancer Institute, Common Terminology Criteria for Adverse Events) at every drug administration. In contrast, QOL was assessed using EORTC QLC-CIPN20 and FACT-Taxane questionnaire at baseline (T0), after 4 weeks (T1) and 12 (T2) weeks of treatment. Statistical analysis was performed to evaluate the correlation between neurotoxicity and QOL.

Results
Neurotoxicity incidence peaked at the third, fourth, and sixth week of treatment, with patients reporting grade 1 and 2 neurotoxicity. Simultaneously with increasing doses of paclitaxel, significant differences in QOL were observed in early treatment cycles relating to TIN presentation. Patients with higher neurotoxicity grades reported lower QOL scores.

Conclusions
Despite the absence of effective treatments to prevent paclitaxel-induced neurotoxicity, symptoms are managed through dosage reduction, delay, or treatment interruption. Future research should focus on identifying neuroprotective measures to avoid an irreversible decline in the quality of life for breast cancer survivors.
Preservation of emotional context in tweet embeddings on social networking sites
Authors: Maruyama Osamu , Yoshinaga Asato , Sawai Ken-ichi 
Published: October 2024

AbstractIn communication, emotional information is crucial, yet its preservation in tweet embeddings remains a challenge. This study aims to address this gap by exploring three distinct methods for generating embedding vectors of tweets: word2vec models, pre-trained BERT models, and fine-tuned BERT models. We conducted an analysis to assess the degree to which emotional information is conserved in the resulting embedding vectors. Our findings indicate that the fine-tuned BERT model exhibits a higher level of preservation of emotional information compared to other methods. These results underscore the importance of utilizing advanced natural language processing techniques for preserving emotional context in text data, with potential implications for enhancing sentiment analysis and understanding human communication in social media contexts.
A Reformulation of the Laminar Kinetic Energy Model to Enable Multi-mode Transition Predictions
Authors: Pacciani Roberto , Fang Yuan , Metti Leonardo , Marconcini Michele , Sandberg Richard 
Published: October 2024

Abstract
The paper describes the development of a novel transition/turbulence model based on the laminar kinetic energy concept. The model is intended as a base framework for data-driven improvements. Starting from a previously developed framework, mainly aimed at separated-flow transition predictions, suitable terms for model generalization are identified and reformulated for handling different transition modes, namely bypass and separated-flow modes. The ideology for the definition of new terms has its roots in mixing phenomenological and correlation-based arguments, ensuring generality and flexibility and allowing a variety of lines of action for improving model components via machine-learning approaches. The model calibration, carried out with reference to flat plate test cases subjected to different pressure gradients and freestream turbulence levels, is discussed in detail. Although the constructed model is calibrated on a group of classic flat plat cases, the validation campaign, mostly carried out on gas turbine cascades, demonstrates its ability to predict transitional flows with engineering accuracy. Finally, while the model is not specifically developed for natural transition predictions, satisfactory predictions are obtained in scenarios with low freestream turbulence for flat plate and airfoil flows.
Capture, commodify, kill: Legitimized harms and industrial meatpacking in the united states
Authors: León Kenneth Sebastian , Ken Ivy , Martin Theo 
Published: October 2024

AbstractSlaughtering and processing animals on an industrial scale are complicated activities that are both highly prominent in the food system and intentionally concealed from the public. The structural violence enacted within this industry deserves attention as a direct form of state-corporate harm. To this end, this paper invokes Tombs and Whyte’s imaginaries of corporate crime to understand what they might call the “ceaseless repetition” through which harms against workers, animals, and the environment in the meatpacking industry are enacted. From this application in the context of a Marxian analysis of primitive accumulation, we have determined the importance of capital’s ability to capture, commodify, and kill (CCK) – concepts we offer together as a heuristic device to highlight the types of harm done to labor, animals, and land, and to explain how these harms are accomplished. Drawing on the copious literature on meatpacking, as well as our own direct observations of the industry, this paper emphasizes the role of food systems for white-collar and corporate crime specialists interested in policy and social change.
Multilateral environmental agreements as information media: their functions and a theoretical framework
Authors: Ohtani Shimon 
Published: October 2024

AbstractMultilateral Environmental Agreements (MEAs), which have increased since the 1970s to address global environmental issues, have persistently tended to be analyzed and evaluated in terms of their aspects as international law in global environmental governance studies. However, research to improve the quality of communication by identifying information that influences the inner lives of non-state actors, especially their normative attitudes and behavioral intentions that directly affect their behavioral change, still needs to be established. We focus on another aspect, MEAs as information media. In the process of gradual development from their entry into force, MEAs continuously absorb all kinds of information and release new information. We named such an information refinement process “The Metabolism of Information.” Emphasizing the function of MEAs as information media promotes a shift to emerging research approaches emphasizing the information transfer process. Among these, we propose one theoretical framework, focusing on the utility of Sentiment Analysis using Natural Language Processing (NLP) and the need to combine it with Environmental Psychological theories to apply the results. This integrated framework has modeled a series of processes that make the most of the immediacy of information technology and enable policy reflection with immediate effect and is expected to be discussed as bridging the gap between Sentiment Analysis and practical policy building. In the future, investing in human resources and technical equipment and interdisciplinary collaboration would be crucial to address ethical issues in anticipation of an accelerated shift to data-driven research approaches to promote MEAs as information media.
Automatic Enrollment in Patient Portal Systems Mitigates the Digital Divide in Healthcare: An Interrupted Time Series Analysis of an Autoenrollment Workflow Intervention
Authors: Milanfar Leila , Soulsby William Daniel , Ling Nicole , O’Brien Julie S. , Oates Aris , McCulloch Charles E. 
Published: October 2024

Abstract

Purpose
Racial and ethnic healthcare disparities require innovative solutions. Patient portals enable online access to health records and clinician communication and are associated with improved health outcomes. Nevertheless, a digital divide in access to such portals persist, especially among people of minoritized race and non-English-speakers. This study assesses the impact of automatic enrollment (autoenrollment) on patient portal activation rates among adult patients at the University of California, San Francisco (UCSF), with a focus on disparities by race, ethnicity, and primary language.

Materials and methods
Starting March 2020, autoenrollment offers for patient portals were sent to UCSF adult patients aged 18 or older via text message. Analysis considered patient portal activation before and after the intervention, examining variations by race, ethnicity, and primary language. Descriptive statistics and an interrupted time series analysis were used to assess the intervention’s impact.

Results
Autoenrollment increased patient portal activation rates among all adult patients and patients of minoritized races saw greater increases in activation rates than White patients. While initially not statistically significant, by the end of the surveillance period, we observed statistically significant increases in activation rates in Latinx (3.5-fold, p = < 0.001), Black (3.2-fold, p = 0.003), and Asian (3.1-fold, p = 0.002) patient populations when compared with White patients. Increased activation rates over time in patients with a preferred language other than English (13-fold) were also statistically significant (p = < 0.001) when compared with the increase in English preferred language patients.

Conclusion
An organization-based workflow intervention that provided autoenrollment in patient portals via text message was associated with statistically significant mitigation of racial, ethnic, and language-based disparities in patient portal activation rates. Although promising, the autoenrollment intervention did not eliminate disparities in portal enrollment. More work must be done to close the digital divide in access to healthcare technology.
Varieties of Consequentialism and Deontology in Theories of Tort Law
Authors: Slavny Adam 
Published: October 2024

AbstractAn important contribution of Gregory Keating’s Reasonableness and Risk is to mount objections to law and economics whilst articulating an alternative deontological vision of tort law to that offered by corrective justice theorists. In this paper I offer two reservations about Keating’s account. One is that some forms of consequentialism can accommodate at least some aspects of his deontological theory, so we must be careful to distinguish between claims that strike at the heart of consequentialism and those that are only a problem for wealth maximisation. The second is that there are yet other varieties of deontology besides Kantianism and Keating’s alternative to it, and while I accept some of Keating’s claims, I think we should reject others. I will make the case for each of these reservations via discussion of three core features of Keating’s account: the harm/benefit asymmetry, the commitment to objective rather than subjective valuation, and his justification of strict liability.
Implementation of an exact completing method of generation for face-milled spiral bevel gears with uniform depth taper
Authors: Gonzalez-Perez Ignacio , Fuentes-Aznar Alfonso 
Published: October 2024

AbstractThis paper proposes an exact completing method of generation of face-milled spiral bevel gears with uniform depth taper. This method ensures localized bearing contact without kinematic transmission errors in both directions of rotation. Both sides of the tooth are generated simultaneously using the same set of basic machine tool settings. A tip relief on the tooth surfaces is the only required microgeometry modification to achieve a smooth transition of load between consecutive pairs of teeth. An analytical approach to determine the basic machine tool settings and select the grinding cutter parameters has been also developed. The selection of the nominal cutter radius follows the recommendations of Information Sheet AGMA 22849-A12. The basis for alignment error compensation has been also established. Tooth contact and stress analyses demonstrate the advantages and limitations of the proposed method, making it suitable for applications with higher power demands for the drive side than for the coast side.
Reliability of Theory of Mind Tasks in Schizophrenia, ASD, and Nonclinical Populations: A Systematic Review and Reliability Generalization Meta-analysis
Authors: Tsui Harry Kam Hung , Wong Ting Yat , Ma Chak Fai , Wong Ting Eva , Hsiao Janet , Chan Sherry Kit Wa 
Published: October 2024

AbstractThough theory of mind (ToM) is an important area of study for different disciplines, however, the psychometric evaluations of ToM tasks have yielded inconsistent results across studies and populations, raising the concerns about the accuracy, consistency, and generalizability of these tasks. This systematic review and meta-analysis examined the psychometric reliability of 27 distinct ToM tasks across 90 studies involving 2771 schizophrenia (SZ), 690 autism spectrum disorder (ASD), and 15,599 nonclinical populations (NC). Findings revealed that while all ToM tasks exhibited satisfactory internal consistency in ASD and SZ, about half of them were not satisfactory in NC, including the commonly used Reading the Mind in the Eye Test and Hinting Task. Other than that, Reading the Mind in the Eye Test showed acceptable reliability across populations, whereas Hinting Task had poor test–retest reliability. Notably, only Faux Pas Test and Movie for the Assessment of Social Cognition had satisfactory reliability across populations albeit limited numbers of studies. However, only ten studies examined the psychometric properties of ToM tasks in ASD adults, warranting additional evaluations. The study offered practical implications for selecting ToM tasks in research and clinical settings, and underscored the importance of having a robust psychometric reliability in ToM tasks across populations.
Identifying and classifying broader scale of disaster impacts to better inform disaster management policies and practice
Authors: Tennakoon Kishani Priyangi , Serrao-Neumann Silvia , Cretney Raven 
Published: October 2024

Abstract
Disasters are often assessed by factors such as their magnitude, severity and impact on affected communities. Typically, disaster management policies are largely informed by learnings from large-scale disasters. Many studies, however, have shown that cumulative smaller scale disaster impacts have similar outcomes comparable to larger scale disasters. This indirectly contributes to a lack of consistency in and paucity of data related to both smaller-scale disasters and their associated cumulative impacts. This paper argues that greater attention needs to be paid to collecting disaster impact data on a range of disaster-scale events along with their cumulative impacts to better inform disaster management policies and practice. The paper aims to test the hypothesis that a better understanding of a wide range of disaster scale types and their impacts on communities, including small-scale disasters, enables the development of more just, consistent and equitable disaster management policies and practice. Analysing economic costs, evacuation and rainfall data from past flood events that affected Aotearoa-New Zealand over the last three decades, the paper found discrepancies and lack of coherence in disaster data collection and reporting, along with a predominant reliance on rainfall intensity data for disaster risk reduction and planning. The findings also confirmed the importance of identifying economic damages for a range of disaster scales, including those from small-scale disasters. This highlights the need for developing a spectrum to better classify and identify disaster impacts based on various spatial and temporal contexts. The paper concludes by affirming that such database would provide much needed evidence for developing a methodology that enables the identification of the level of disaster impacts; thereby guiding the implementation of more just, consistent and equitable disaster management policies and practice.
In search of lost principles: generic generalism in aesthetics and ethics
Authors: Lord Errol 
Published: October 2024

AbstractI defend a form of generalism in ethics and aesthetics. Generalism about a domain D is the view that there are principles that play an explanatory role in the metaphysics of D and can be used in reasoning when thinking about D. I argue that in both aesthetics and ethics, there are generic generalizations that are principles. I do this by (i) explaining the nature of a particularly important kind of generic, (ii) argue that generics of this kind play a explanatory role, and (iii) argue that we licitly use these truths in reasoning about ethics and aesthetics.
Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25–57% elevation in risk
Authors: Ungvari Zoltan , Fekete Mónika , Varga Peter , Lehoczki Andrea , Fekete János Tibor , Ungvari Anna , Győrffy Balázs 
Published: October 2024

AbstractThe incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk factor. Numerous studies suggest a strong correlation between excess body weight and increased risk of CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review and meta-analyze the existing literature to evaluate the association between obesity and CRC risk, considering variations across sex and study designs. A systematic literature search was conducted in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to identify randomized controlled trials and human clinical trials from 1992 to 2024. Statistical analysis was performed using the https://metaanalysisonline.com web application using a random effects model to estimate the pooled hazard rates (HR). Forest plots, funnel plots, and Z-score plots were utilized to visualize results. We identified 52 clinical trials and 14 case–control studies, encompassing a total of 83,251,050 and 236,877 subjects, respectively. The pooled analysis indicated that obesity significantly increased the prevalence of CRC (HR = 1.36, 95% CI = 1.24–1.48, p < 0.01). This effect was consistent across sexes, with HRs of 1.57 (95% CI = 1.38–1.78, p = 0.01) for males and 1.25 (95% CI = 1.14–1.38, p < 0.01) for females. Case–control studies specifically showed an effect, but with marginal significance only (HR = 1.27, 95% CI = 0.98–1.65, p = 0.07). The Z-score plot indicated the need for additional analysis in the case–control group. A significant heterogeneity was observed across studies in all four settings. This meta-analysis provides robust evidence that obesity is a significant risk factor for colorectal cancer, with an overall hazard rate indicating a 36% increased risk. The effect is pronounced across both sexes, with males showing a slightly higher risk compared to females. Although case–control studies showed a weaker association, the overall trend supports the link between obesity and CRC. These results underscore the importance of public health interventions aimed at reducing obesity to potentially lower the risk of colorectal cancer.
Efficacy and Safety of Andexanet Alfa Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta-Analysis
Authors: Sarhan Khalid , Mohamed Rashad G. , Elmahdi Reem Reda , Mohsen Youstina , Elsayed Asmaa , Zayed Dania Mosaad , Elkholi Menna A. , Gabr Nagat , El-Bialy Enjy M. , Serag Ibrahim 
Published: October 2024

AbstractFactor Xa inhibitors (FXaI) are increasingly used for anticoagulation therapy, yet their association with intracranial hemorrhage poses a significant challenge. Although andexanet alfa (AA) and four-factor prothrombin complex concentrate (4F-PCC) have shown promise in reversing FXaI effects, their comparative efficacy and safety remain uncertain. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until May 16, 2024. Our primary outcomes were successful anticoagulation reversal, overall mortality (including 30-day and in-hospital mortality), and thromboembolic events. Secondary outcomes were length of hospital and intensive care unit stay and hematoma volume expansion. Data were pooled using a random-effects model. We included 16 eligible studies with a total of 2,977 patients. A statistically significant improvement in hemostatic efficacy rates was in favor of the AA group (risk ratio [RR] 1.10, 95% confidence interval [CI] 1.01–1.20, P = 0.02). Lower overall mortality rates were found in the AA group (RR 0.67, 95% CI 0.51–0.88, P = 0.004). However, no difference was found in 30-day mortality rates (RR 0.82, 95% CI 0.58–1.16, P = 0.26). In terms of thromboembolic events, more events were found in the AA group (RR 1.47, 95% CI 1.01–2.15, P = 0.046). AA was associated with a longer duration of hospital stay compared to 4F-PCC (mean difference [MD] 0.64, 95% CI 0.07–1.22, P = 0.03). Neither a significant difference in length of intensive care unit stay (MD 0.25, 95% CI − 0.36 to 0.86, P = 0.41) nor a significant difference in hematoma volume expansion was reported (MD − 0.89, 95% CI − 3.11 to 1.34, P = 0.435). Our results suggest that AA is superior to 4F-PCC in enhancing the hemostatic efficacy and reducing the overall and in-hospital mortality rates. More thromboembolic events are thought to be associated with the use of AA. However, more studies are required to validate whether the better results of AA in improving hemostatic efficacy are enough to make up for their higher cost and their possible risk of thromboembolic events.