bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and modeling of the potential effects of a module manufacturing anomaly
Authors: Kempe Michael D. , Jordan Dirk C. 
Published: July 2017

AbstractPhotovoltaic lifetime predictions are in great demand, but are exceedingly difficult to achieve with uncertainties small enough to be useful. During the construction of photovoltaic modules, small unplanned variability in materials or processes can have profound effects on module durability. Thus, continual monitoring of production quality is needed. In the subject production run, module quality, as monitored by damp heat testing, revealed a subset of modules that were prone to higher degradation rates.An assessment of the potential long‐term power loss and mitigation strategies was needed. To do this, modules were exposed to variable levels of humidity and temperature with periodic monitoring. The analysis takes into account the kinetics of the degradation and the spatially and temporally varying humidity content within the module during accelerated stress testing. This is an important aspect for extrapolating laboratory results to field exposure because moisture ingress is diffusion limited in most laboratory module tests but not limited in these fielded modules. This analysis predicted that although a solder flux induce degradation mechanism is significant in accelerated stress test, this is probably an artifact of a process with a very large acceleration factor that is not likely to be significant for deployed modules. The degradation mechanism affected a limited area around the tabbing helping to minimize the effect. Three years after the system was commissioned, the fielded modules indeed show no significant power loss.
Evaluating brominated thioxanthones as organo‐photocatalysts
Authors: Iyer Akila , Clay Anthony , Jockusch Steffen , Sivaguru J. 
Published: July 2017

AbstractBromination of the widely used triplet sensitizer thioxanthone extends the absorption spectrum into the visible range with only minor loss of lowest triplet state energy (3 kcal/mol for di‐bromination). Because of bromine substitution, a slight increase in triplet quantum yield was observed. The di‐brominated derivative was effective as organo‐photocatalyst in performing [2 + 2] cross‐photocycloaddition of acrylimide‐based compounds under visible light irradiation.
Development of an electrochromic device triggered by the macrocell current in chloride‐induced corrosion of steel‐reinforced concrete
Authors: Juraschek Thomas , Weichold Oliver 
Published: July 2017

AbstractThis article presents the development and characterisation of an electrochromic device and its application to detect steel corrosion in reinforced concrete. Steel corrosion inflicts an enormous annual economic damage, which could be reduced by the installation of appropriate monitoring devices. These should be simple, reliable, long lasting, and should not require service or maintenance. The present electrochromic device is constructed in such a way that it uses the macrocell current in an active, chloride‐induced corrosion element as power supply to trigger the colour change. This way, the system stays inactive until corrosion occurs. The device consists of diheptyl viologen in a liquid polymer electrolyte made from LiClO4 and poly(ethylene glycol) with
= 400 g mol−1. The addition of viologen lowers the resistance but causes no further changes in the electrochemical properties of the polymer electrolyte. Impedance spectra indicate ion transport rather than capacitance effects to dominate the electrochemical properties. Experiments using direct current in the microampere range show electrochromic switching times of several minutes, which is sufficient for the intended monitoring application.
Target‐site resistance to acetolactate synthase (ALS)‐inhibiting herbicides in Amaranthus palmeri from Argentina
Authors: Larran Alvaro S , Palmieri Valeria E , Perotti Valeria E , Lieber Lucas , Tuesca Daniel , Permingeat Hugo R 
Published: July 2017

AbstractBACKGROUNDHerbicide‐resistant weeds are a serious problem worldwide. Recently, two populations of Amaranthus palmeri with suspected cross‐resistance to acetolactate synthase (ALS)‐inhibiting herbicides (R1 and R2) were found by farmers in two locations in Argentina (Vicuña Mackenna and Totoras, respectively). We conducted studies to confirm and elucidate the mechanism of resistance.RESULTSWe performed in vivo dose–response assays, and confirmed that both populations had strong resistance to chlorimuron‐ethyl, diclosulam and imazethapyr when compared with a susceptible population (S). In vitro ALS activity inhibition tests only indicated considerable resistance to imazethapyr and chlorimuron‐ethyl, indicating that other non‐target mechanisms could be involved in diclosulam resistance. Subsequently, molecular analysis of als nucleotide sequences revealed three single base‐pair mutations producing substitutions in amino acids previously associated with resistance to ALS inhibitors, A122, W574, and S653.CONCLUSIONThis is the first report of als resistance alleles in A. palmeri in Argentina. The data support the involvement of a target‐site mechanism of resistance to ALS‐inhibiting herbicides. © 2017 Society of Chemical Industry
Chemical Characterization, Antileishmanial Activity, and Cytotoxicity Effects of the Essential Oil from Leaves of Pluchea carolinensis (Jacq.) G. Don. (Asteraceae)
Authors: García Marley , Scull Ramón , Satyal Prabodh , Setzer William N. , Monzote Lianet 
Published: July 2017

Current strategies to control leishmaniasis are mainly based on chemotherapy. However, none of the available drugs can be considered to be ideal to treat this disease. Because of the hydrophobic nature and bioactivities of their components, essential oils (EOs) can be considered as important sources for developing agents against intracellular pathogens, such as Leishmania parasites. In this study, we report the chemical characterization, antileishmanial activities, and cytotoxicity effect of the EO from Pluchea carolinensis (Jacq.) G. Don. (Asteraceae). Chemical analysis revealed that EO from aerial part from P. carolinensis is composed of 44 compounds. The main component was selin‐11‐en‐4α‐ol, which made up 51.0%. In vitro antileishmanial studies showed that P. carolinensis EO inhibited the growth of promastigotes (IC50 = 24.7 ± 7.1 μg/mL) and amastigotes (IC50 = 6.2 ± 0.1 μg/mL) of Leishmania amazonensis, while cytotoxicity evaluation revealed fivefold higher values than those for the parasites. In a model of experimental cutaneous leishmaniasis in BALB/c mice, five doses of EO at 30 mg/kg by intralesional route demonstrated smaller lesion size and parasite burden (p < 0.05) compared with animals treated with Glucantime® and untreated mice. In conclusion, in vitro and in vivo results showed the potentialities of EO from P. carolinensis with the future possibility of a new alternative in the treatment for leishmaniasis. Copyright © 2017 John Wiley & Sons, Ltd.
Lipid profiling of complex biological mixtures by liquid chromatography/mass spectrometry using a novel scanning quadrupole data‐independent acquisition strategy
Authors: Gethings Lee A. , Richardson Keith , Wildgoose Jason , Lennon Sarah , Jarvis Sheba , Bevan Charlotte L. , Vissers Johannes P.C. , Langridge James I. 
Published: July 2017

RationaleA novel data‐independent acquisition method is detailed that incorporates a scanning quadrupole in front of an orthogonal acceleration time‐of‐flight (TOF) mass analyser. This approach is described and the attributes are compared and contrasted to other DIA approaches.MethodsSpecific application of the method to both targeted and untargeted lipidomic identification strategies is discussed, with data from both shotgun and LC separated lipidomics experiments presented.ResultsThe benefits of the fast quadrupole scanning technique are highlighted, and include improvements in speed and specificity for complex mixtures providing high quality qualitative and quantitative data.ConclusionsIn particular the high specificity afforded by the scanning quadrupole improves qualitative information for lipid identification.
Stressful life events and posttraumatic growth among police officers: A cross‐sectional study
Authors: Leppma Monica , Mnatsakanova Anna , Sarkisian Khachatur , Scott Olivia , Adjeroh Leonie , Andrew Michael E. , Violanti John M. , McCanlies Erin C. 
Published: July 2017

AbstractPolice officers often continue to face numerous threats and stressors in the aftermath of a disaster. To date, posttraumatic growth (PTG) has been studied primarily in the context of significant trauma; thus, it is not known whether stressful life events are associated with PTG. This study investigated the development of PTG among 113 police officers working in the New Orleans area following Hurricane Katrina. Hierarchical regression was used to evaluate if gratitude, social support, and satisfaction with life moderated the relationship between stressful life events (as measured by the total life stress score) and PTG, after adjustment for age, sex, race, level of involvement in Hurricane Katrina, and alcohol intake. Results indicate that stressful life events are independently associated with PTG. Gratitude, satisfaction with life, and social support were seen to moderate this relationship; as stressful life events increased so too did PTG—particularly among officers with higher levels of gratitude (B = 0.002, p ≤ .05), satisfaction with life (B = 0.002, p ≤ .05), and social support (B = 0.001, p ≤ .05). These findings suggest that promoting satisfaction with life, interpersonal support, and gratitude may be beneficial to those who are regularly at risk of trauma exposure.
STOCHASTIC CLAIMS RESERVING VIA A BAYESIAN SPLINE MODEL WITH RANDOM LOSS RATIO EFFECTS
Authors: Gao Guangyuan , Meng Shengwang 
Published: July 2017

AbstractWe propose a Bayesian spline model which uses a natural cubicB-spline basis with knots placed at every development period to estimate the unpaid claims. Analogous to the smoothing parameter in a smoothing spline, shrinkage priors are assumed for the coefficients of basis functions. The accident period effect is modeled as a random effect, which facilitate the prediction in a new accident period. For model inference, we use Stan to implement the no-U-turn sampler, an automatically tuned Hamiltonian Monte Carlo. The proposed model is applied to the workers' compensation insurance data in the United States. The lower triangle data is used to validate the model.
Guardianship and Health Decisions in China and Australia: A Comparative Analysis
Authors: WILLMOTT Lindy , WHITE Ben , STACKPOOLE Christopher , THEN Shih-Ning , MAN Hongjie , YU Mei , SHEN Weixing 
Published: July 2017

AbstractThis article compares the Australian and Chinese adult guardianship systems, and considers whether there is potential for drawing on some (or many) aspects of the Australian model for the Chinese legal framework. Australia has a well-developed guardianship framework that provides mechanisms for making healthcare decisions when an adult is no longer able to do so. This framework has evolved over many years and, in some cases, individuals can decide about medical treatment in advance of the situation arising, or who should be the decision-maker if he or she later loses capacity. The current Chinese legal framework, on the other hand, is a fragmented one and comprises laws that were not designed to deal with how healthcare decisions can be made for a person without capacity. This article outlines the legal framework in both jurisdictions and considers whether, having regard to the fact that these two countries have different values and cultures, there are features of the Australian guardianship system that could inform the development of Chinese law.
Outbreak characteristics associated with identification of contributing factors to foodborne illness outbreaks
Authors: BROWN L. G. , HOOVER E. R. , SELMAN C. A. , COLEMAN E. W. , SCHURZ ROGERS H. 
Published: July 2017

SUMMARYInformation on the factors that cause or amplify foodborne illness outbreaks (contributing factors), such as ill workers or cross-contamination of food by workers, is critical to outbreak prevention. However, only about half of foodborne illness outbreaks reported to the United States’ Centers for Disease Control and Prevention (CDC) have an identified contributing factor, and data on outbreak characteristics that promote contributing factor identification are limited. To address these gaps, we analyzed data from 297 single-setting outbreaks reported to CDC's new outbreak surveillance system, which collects data from the environmental health component of outbreak investigations (often called environmental assessments), to identify outbreak characteristics associated with contributing factor identification. These analyses showed that outbreak contributing factors were more often identified when an outbreak etiologic agent had been identified, when the outbreak establishment prepared all meals on location and served more than 150 meals a day, when investigators contacted the establishment to schedule the environmental assessment within a day of the establishment being linked with an outbreak, and when multiple establishment visits were made to complete the environmental assessment. These findings suggest that contributing factor identification is influenced by multiple outbreak characteristics, and that timely and comprehensive environmental assessments are important to contributing factor identification. They also highlight the need for strong environmental health and food safety programs that have the capacity to complete such environmental assessments during outbreak investigations.
Quick specifications for the busy programmer
Authors: SMALLBONE NICHOLAS , JOHANSSON MOA , CLAESSEN KOEN , ALGEHED MAXIMILIAN 
Published: July 2017

AbstractQuickSpec is a theory exploration system which tests a Haskell program to find equational properties of it, automatically. The equations can be used to help understand the program, or as lemmas to help prove the program correct. QuickSpec is largely automatic: the user just supplies the functions to be tested and QuickCheck data generators. Previous theory exploration systems, including earlier versions of QuickSpec itself, scaled poorly. This paper describes a new architecture for theory exploration with which we can find vastly more complex laws than before, and much faster. We demonstrate theory exploration in QuickSpec on problems both from functional programming and mathematics.
Bereavement support standards and bereavement care pathway for quality palliative care
Authors: Hudson Peter , Hall Chris , Boughey Alison , Roulston Audrey 
Published: July 2017

ABSTRACTObjective:Provision of bereavement support is an essential component of palliative care service delivery. While bereavement support is integral to palliative care, it is typically insufficiently resourced, under-researched, and not systematically applied. Our aim was to develop bereavement standards to assist palliative care services to provide targeted support to family caregivers.Method:We employed a multiple-methods design for our study, which included: (1) a literature review, (2) a survey of palliative care service providers in Australia, (3) interviews with national (Australian) and international experts, (4) key stakeholder workshops, and (5) a modified Delphi-type survey.Results:A total of 10 standards were developed along with a pragmatic care pathway to assist palliative care services with implementation of the standards.Significance of results:The bereavement standards and care pathway constitute a key initiative in the evolution of bereavement support provided by palliative care services. Future endeavors should refine and examine the impact of these standards. Additional research is required to enhance systematic approaches to quality bereavement care.
Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress
Authors: Di Mingxue , Wang Lin , Li Mengmeng , Zhang Yu , Liu Xinxin , Zeng Renya , Wang Han , Chen Yifei , Chen Weijia , Zhang Yun , Zhang Mei 
Published: July 2017

AbstractSeveral clinical studies reported that Dickkopf1 (DKK1) plasma levels are correlated with atherosclerosis. However, the impact of DKK1 on the formation and vulnerability of atherosclerotic plaques remains elusive. This study investigated DKK1’s effects on enlargement and destabilization of plaques by targeting endothelial cells and assessing the possible cellular mechanisms involved. The effects of DKK1 on atherogenesis and plaque stability were evaluated in ApoE−/− mice using lentivirus injections to knockdown and knock-in the DKK1 gene. The presence of DKK1 resulted in enlarged and destabilized atherosclerotic lesions and increased apoptosis, while silencing of DKK1 alleviated plaque formation and vulnerability in the whole progression of atherosclerosis. DKK1 expression was upregulated in response to ox-LDL treatment in a time- and concentration-dependent manner on human umbilical vein endothelial cell (HUVEC). The interference of DKK1 reversed ox-LDL-induced apoptosis in HUVECs. The mechanism underlying this effect was DKK1’s activation of the JNK signal transduction pathway and inhibition of canonical Wnt signaling, following by activation of the IRE1α and eif2α/CHOP pathways. In conclusion, DKK1 promotes plaque formation and vulnerability partly by inducing apoptosis in endothelial cells, which partly through inducing the JNK-endoplasmic reticulum stress pathway and inhibiting canonical Wnt signaling.
A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients
Authors: Khalaj Kasra , Ahn Soo Hyun , Bidarimath Mallikarjun , Nasirzadeh Yasmin , Singh Sukhbir S. , Fazleabas Asgerally T. , Young Steven L. , Lessey Bruce A. , Koti Madhuri , Tayade Chandrakant 
Published: July 2017

AbstractEndometriosis, a major reproductive pathology affecting 8–10% of women is characterized by chronic inflammation and immune dysfunction. Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines involved in inflammation including: tumor necrosis factor alpha (TNF-α), granulocyte macrophage colony stimulating factor (GM-CSF), interleukin 6 (IL-6) among others, and stabilize and destabilize them, respectively. The aim of this study was to examine RNA binding protein (RNABP) HuR/TTP axis in endometriosis patients compared to menstrual stage matched healthy fertile controls in hopes of better understanding their contribution to the pathogenesis of endometriosis. Additionally, using a targeted in vitro siRNA approach, we examined whether knock-down of TTP can play a functional role on other RNABPs that competitively bind to inflammatory targets of TTP in both endometriotic and endometrial epithelial cell lines. Our results suggest that RNABPs TTP and HuR are dysregulated in endometriotic lesions compared to matched eutopic patient samples as well endometrium from healthy controls. Silencing of TTP in endometriotic and endometrial epithelial cells revealed differential response to inflammatory cytokines and other RNABPs. Our results suggest potential involvement of HuR/TTP RNA binding protein axis in regulation of inflammation in endometriosis.
Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles
Authors: O’Brien Michelle , Baczyk Dora , Kingdom John C. 
Published: July 2017

AbstractIn severe early-onset preeclampsia (sPE) the placenta releases soluble angiogenesis-regulating proteins, trophoblast-derived fragments, and extracellular vesicles (EVs). Their relative importance in disease pathogenesis is not presently understood. We explanted placental villi from healthy and sPE women then separated the media into: total-conditioned, EV-depleted and EV-enriched media. Three fractions were compared for; angiogenic protein secretion by ELISA, angiogenic and inflammation gene mRNA expression and leukocyte adhesion assay. sPE placental villi secreted significantly less PlGF (70 ± 18 pg/mL) than preterm controls (338 ± 203; p = 0.03). sFlt-1:PlGF ratios in total-conditioned (115 ± 29) and EV-depleted media (136 ± 40) from sPE placental villi were significantly higher than in EV-enriched media (42 ± 12; p < 0.01) or any preterm or term media. Fluorescent-labeled EVs derived across normal gestation, but not from sPE, actively entered HUVECs. From sPE placental villi, the soluble fraction, but not EV-enriched fraction, significantly repressed angiogenesis (0.83 ± 0.05 fold, p = 0.02), induced HO-1 mRNA (15.3 ± 5.1 fold, p < 0.05) and induced leukocyte adhesion (2.2 ± 0.4 fold, p = 0.04). Soluble media (total-conditioned and EV-depleted media) from sPE placental villi induced endothelial dysfunction in HUVEC, while the corresponding EV-enriched fraction showed no such effects. Our data suggest that soluble factors including angiogenesis-regulating proteins, dominate the vascular pathology of this disease.
The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer
Authors: Li Shu-Qin , Su Ning , Gong Ping , Zhang Hai-Bo , Liu Jin , Wang Ding , Sun Yan-Ping , Zhang Yan , Qian Feng , Zhao Bo , Yu Yang , Ye Richard D. 
Published: July 2017

AbstractFormyl peptide receptors (FPRs) are G protein-coupled chemoattractant receptors expressed mainly in phagocytic leukocytes. High expression of FPRs has also been detected in several cancers but the functions of FPR1 in tumor invasion and metastasis is poorly understood. In this study, we investigated the expression of FPRs in primary human colorectal cancer (CRC) and analyzed the association of FPRs expression with clinicopathological parameters. The levels of FPRs mRNA, especially those of FPR1, were significantly higher in colorectal tumors than in distant normal tissues and adjacent non-tumor tissues. FPR1 mRNA expression was also associated with tumor serosal infiltration. FPR1 protein expression was both in the colorectal epitheliums and tumor infiltrating neutrophils/macrophages. Furthermore, the functions of FPR1 in tumor invasion and tissue repair were investigated using the CRC cell lines SW480 and HT29. Higher cell surface expression of FPR1 is associated with significantly increased migration in SW480 cells compared with HT29 cells that have less FPR1 membrane expression. Finally, genetic deletion of fpr1 increased the survival rate of the resulting knockout mice compared with wild type littermates in a mouse model of colitis-associated colorectal cancer. Our data demonstrate that FPR1 may play an important role in tumor cell invasion in CRC patients.
Y croire ou ne pas y croire: ‘L’Ermite’ d’Apollinaire
Authors: Ettlin Annick 
Published: July 2017

Abstract

Souvent ignoré par la critique, le poème d’Apollinaire intitulé ‘L’Ermite’, repris dans
Alcools
, témoigne de son entrée en poésie. Parce qu’il s’inspire d’une manière, de thèmes et de motifs typiques du symbolisme, qu’il arbore une dédicace ‘à Félix Fénéon’ servant à rappeler sa première publication, alors particulièrement significative pour le jeune auteur en quête de reconnaissance, mais aussi parce qu’il met en scène un personnage aux prises avec un dilemme métaphysique, sommé de ‘croire ou ne pas croire’ à l’amour, à la poésie aussi, ces jeux du cœur ou de l’esprit pour lesquels il éprouve un désir violent, le poème permet de réfléchir d’une part aux enjeux sociologiques et d’autre part aux raisons théoriques du geste que commet celui qui opte pour la littérature. Il évoque au moyen d’une allégorie métapoétique, dont il n’est pas évident de déterminer le degré de sérieux, cet ‘investissement’ au sujet duquel Pierre Bourdieu inventera plus tard le concept d’
illusio
, qu’il invite à renégocier. Soumis dans cet article à une lecture rapprochée, le poème d’Apollinaire engage en outre à une réflexion sur la valeur ontologique de la poésie, tiraillée entre un idéal de ‘vérité’ et son accointance pourtant manifeste avec le ‘faux’.