bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive Ion‐Confined Ultracapacitive Memristors with Neuromorphic Functions
Authors: Li Panlong , Feder‐Kubis Joanna , Kunigkeit Jonas , Zielińska‐Błajet Mariola , Brunner Eike , Grothe Julia , Kaskel Stefan 
Published: September 2024

AbstractThe field of bioinspired iontronics, bridging electronic devices and ionic systems, has multiple biological applications. Carbon‐based ultracapacitive devices hold promise for controlling bioactive ions via electric double layers due to their high‐surface‐area and biocompatible porous carbon electrodes. However, the interplay between complex bioactive ions and porous carbons remains unclear due to the variety of structures of bioactive ions present in biological systems. Herein, we investigate the adsorption behavior of a series of bioactive ammonium‐based cations with varying alkyl chain lengths in nanoporous carbons. We find that strong physisorption results from the synergistic hydrophobic interaction and electrostatic attraction between porous carbons (with a negative zeta potential) and bioactive cations. Bioactive cations with varying alkyl chain lengths can be irreversibly physically adsorbed and confined within nanoporous carbons resulting in anion enrichment and depletion during electric polarization. This situation, in turn, results in a characteristic memristive behavior in all‐carbon capacitive ionic memristor devices. Our findings highlight the relationship between the resistance state of the memristor and ion adsorption mechanisms in all‐carbon capacitive devices, which hold potential for future transmitter delivery, biointerfacing, and neuromorphic devices.
Atom‐Efficient Synthesis of Trimethine Cyanines Using Formaldehyde as a Single‐Carbon Source
Authors: Lee Sun Hyeok , Lee Taek‐Jun , Sarkar Sourav , Cho Heewon , Nhu Quynh Pham Nguyen , Chang Young‐Tae 
Published: September 2024

AbstractHerein, we present an innovative and atom‐efficient synthesis of trimethine cyanines (Cy3) using formaldehyde (FA) as a single‐carbon reagent. The widespread application of Cy3 dyes in bioimaging and genomics/proteomics is often limited by synthetic routes plagued by low atom economy and substantial side‐product formation. Through systematic investigation, we have developed a practical and efficient synthetic pathway for both symmetrical and unsymmetrical Cy3 derivatives, significantly minimizing resource utilization. Notably, this approach yields water as the by‐product, in alignment with sustainable chemistry principles. Moreover, the efficient one‐pot synthesis facilitates the detection of intracellular FA levels, utilizing the fluorescence signal of Cy3 in live cells. It is also possible to detect endogenous FA in the intestinal tissues. We observed a significant decrease in FA in the small intestine of inflammatory bowel disease (IBD) mice as compared to healthy mice. This methodological advancement not only enhances the scope of fluorescent dye synthesis but also contributes to sustainable practices within chemical manufacturing, offering a significant leap forward in the development of environmentally friendly synthetic strategies.
Full‐Color Emissive Zirconium‐Organic Frameworks Constructed via in Situ “One‐Pot” Single‐Site Modification for Tryptophan Detection and Energy Transfer
Authors: Fang Pu‐Hao , Qu Lu‐Lu , Ma Zhen‐Sha , Han Chao‐Qin , Li Zhendong , Wang Lei , Zhou Kang , Li Jingbai , Liu Xiao‐Yuan 
Published: September 2024

AbstractOrganic linker‐based luminescent metal–organic frameworks (LMOFs) have received extensive studies due to the unlimited species of emissive organic linkers and tunable structure of MOFs. However, the multiple‐step organic synthesis is always a great challenge for the development of LMOFs. As an alternative strategy, in situ “one‐pot” strategy, in which the generation of emissive organic linkers and sequential construction of LMOFs happen in one reaction condition, can avoid time‐consuming pre‐synthesis of organic linkers. In the present work, we demonstrate the successful utilization of in situ “one‐pot” strategy to construct a series of LMOFs via the single‐site modification between the reaction of aldehydes and o‐phenylenediamine‐based tetratopic carboxylic acid. The resultant MOFs possess csq topology with emission covering blue to near‐infrared. The nanosized LMOFs exhibit excellent sensitivity and selectivity for tryptophan detection. In addition, two component‐based LMOFs can also be prepared via the in situ “one‐pot” strategy and used to study energy transfer. This work not only reports the construction of LMOFs with full‐color emissions, which can be utilized for various applications, but also indicates that in situ “one‐pot” strategy indeed is a useful and powerful method to complement the traditional MOFs construction method for preparing porous materials with tunable functionalities and properties.
Interfacially Fabricated Covalent Organic Framework Membranes for Film‐Based Fluorescence Humidity Sensors and Moisture Driven Actuators
Authors: Liu Xiangquan , Huang Rongrong , Peng Lingya , Yang Jinglun , Yan Junbao , Zhai Binbin , Luo Yan , Zhang Chi , Tan Shuwen , Liu Xiaoyan , Ding Liping , Fang Yu 
Published: September 2024

AbstractRapid, on‐site measurement of ppm‐level humidity in real time remains a challenge. In this work, we fabricated a few micrometer thick, β‐ketoenamine‐linked covalent organic framework (COF) membrane via interfacially confined condensation of 1,3,5‐tris‐(4‐aminophenyl)triazine (TTA) with 1,3,5‐tri‐formylphloroglucinol (TP). Based on the super‐sensitive and reversible response of the COF membrane to water vapor, we developed a high‐performance film‐based fluorescence humidity sensor, depicting unprecedented detection limit of 0.005 ppm, fast response/recovery (2.2 s/2.0 s), and a detection range from 0.005 to 100 ppm. Remarkably, more than 7,000‐time continuous tests showed no observable change in the performance of the sensor. The applicability of the sensor was verified by on‐site and real‐time monitoring of humidity in a glovebox. The superior performance of the sensor was ascribed to the highly porous structure and unique affinity of the COF membrane to water molecules as they enable fast mass transfer and efficient utilization of the water binding sites. Moreover, based on the remarkable moisture driven deformation of the COF membrane and its composition with the known polyimide films, some conceptual actuators were created. This study brings new ideas to the design of ultra‐sensitive film‐based fluorescent sensors (FFSs) and high‐performance actuators.
High Performance Organic Mixed Ionic‐Electronic Polymeric Conductor with Stability to Autoclave Sterilization
Authors: Liao Hailiang , Savva Achilleas , Marsh Adam V. , Yang Yu‐Ying , Faber Hendrik , Rimmele Martina , Sanviti Matteo , Zhou Renqian , Emwas Abdul‐Hamid , Martín Jaime , Anthopoulos Thomas D. , Heeney Martin 
Published: September 2024

AbstractWe present a series of newly developed donor‐acceptor (D‐A) polymers designed specifically for organic electrochemical transistors (OECTs) synthesized by a straightforward route. All polymers exhibited accumulation mode behavior in OECT devices, and tuning of the donor comonomer resulted in a three‐order‐of‐magnitude increase in transconductance. The best polymer gFBT‐g2T, exhibited normalized peak transconductance (gm,norm) of 298±10.4 S cm−1 with a corresponding product of charge‐carrier mobility and volumetric capacitance, μC*, of 847 F V−1 cm−1 s−1 and a μ of 5.76 cm2 V−1 s−1, amongst the highest reported to date. Furthermore, gFBT‐g2T exhibited exceptional temperature stability, maintaining the outstanding electrochemical performance even after undergoing a standard (autoclave) high pressure steam sterilization procedure. Steam treatment was also found to promote film porosity, with the formation of circular 200–400 nm voids. These results demonstrate the potential of gFBT‐g2T in p‐type accumulation mode OECTs, and pave the way for the use in implantable bioelectronics for medical applications.
Epitaxial crystallization of polylactic acid on layered zinc phenylphosphonate: Mutual perpendicular rodlike crystals under two lattice matchings
Authors: Ding Shi‐Juan , Cui Ling‐Na , Liu Yue‐Jun 
Published: September 2024

AbstractAs a highly effective nucleating agent, layered zinc phenylphosphonate (PPZn) is incorporated into polylactic acid (PLA) to investigate the epitaxial crystallization of PLA on PPZn in this study. The corresponding lattice spacing change, crystalline morphology, and crystalline structure are emphasized to reveal the epitaxial crystallization mechanism. As a result, with the increase of PPZn content and the annealing time, the increasing lattice spacing of PPZn and the formation of mutually perpendicular rodlike crystals are observed through x‐ray diffraction (XRD) and polarized optical micrograph (POM) measurements, implying that the interlayer spacing of PPZn crystals is expanded as the PLAα‐form crystals epitaxially grow on its surface, that is, epitaxial crystallization. To be specific, “edge on” lamellae epitaxial grow on the PPZn crystals along the [010] and [100] directions under two excellent lattice matchings, which possess acceptable mismatching of 0.347% and 7.5%, respectively. With the support of the epitaxial crystallization mechanism, the occurrence of the filamentous structure observed in the fracture morphology of PLA/PPZn composites suggests strong interfacial adhesion between PLA and PPZn, which makes the impact toughness of the PLA/PPZn composites increase by 53.6% compared with pure PLA.
Mechanistic Insights and Emerging Trends in Photocatalytic Dye Degradation for Wastewater Treatment
Authors: Tak Sahil , Grewal Sanjeet , Shreya  , Phogat Peeyush , Manisha  , Jha Ranjana , Singh Sukhvir 
Published: September 2024

AbstractThis review explores advancements, challenges, and considerations in photocatalytic dye degradation for sustainable wastewater treatment. It highlights smart photocatalyst design, visible‐light‐responsive materials, and co‐catalyst engineering, which enhance system efficacy. Despite environmental concerns, the eco‐friendly aspects of photocatalysis offer a promising alternative to traditional methods. Future perspectives emphasize nanotechnology's role in developing effective photocatalysts and integrating visible‐light and solar‐driven systems to meet sustainability goals. Efforts in co‐catalyst engineering and reactor design aim to optimize processes, addressing kinetic and scalability challenges, while economic research focuses on reducing costs to improve competitiveness.
Solid‐Acid Catalyzed Continuous‐Flow Aminolysis of Epoxides
Authors: Nishizawa Ken , Saito Yuki , Kobayashi Shū 
Published: September 2024

AbstractWe report a solid‐acid catalyzed aminolysis of epoxides under continuous‐flow conditions. A titania‐zirconia supported molybdenum oxide catalyst demonstrated exceptional substrate compatibility, enabling the synthesis of β‐amino alcohols in excellent yields with high catalyst durability. Characterization of the catalyst revealed the crucial role of the titania‐zirconia ratio in optimizing its performance. Furthermore, this method was applied to the efficient, sequential‐flow synthesis of a rivaroxaban intermediate (an oral anticoagulant and the first direct factor Xa inhibitor), combining a hydrogenation step with the aminolysis reaction without the need for intermediate isolation.
Peptide Catalyzed Conjugate Additions to β‐Nitroacrylates – Steric Bulk Increases the Reaction Rate
Authors: Budinská Alena , Schmutz Luca , Schnurr Martin , Aregger Nina , Hilpert Patrick , Wennemers Helma 
Published: September 2024

AbstractThe organocatalytic conjugate addition of aldehydes to β‐nitroacrylates provides direct access to β‐ester‐γ‐nitroaldehydes and, thereby, common structural motifs of many bioactive compounds. However, the deactivation of amine‐based catalysts by alkylation with the highly electrophilic nitroacrylates hampers this reaction. Here, we show that the peptide H‐Mep‐dPro‐dGlu‐NH2, which is reluctant to undergo alkylation, catalyzes this reaction at low catalyst loading (0.5–1 mol %) within short reaction times (15–60 min) to yield a broad range of β‐ester‐γ‐nitroaldehydes with high stereoselectivity. Kinetic studies revealed that increased steric bulk on the β‐nitroacrylate enhances the reaction rate by hindering catalyst alkylation.
Colitis in a patient with familial Mediterranean fever: Is it Crohn's disease or ulcerative colitis?
Authors: Hoshi Ayano , Shimodate Yuichi , Gotoda Tatsuhiro , Takezawa Rio , Nishimura Naoyuki , Mouri Hirokazu , Matsueda Kazuhiro , Mizuno Motowo , Matsumoto Takayuki 
Published: September 2024

AbstractA 24‐year‐old woman was referred to our hospital with joint pain, fever, abdominal pain, and diarrhea. A colonoscopy revealed longitudinal ulcers with a cobblestone appearance throughout the entire colon, suggestive of Crohn's disease. However, treatment with 5‐aminosalicylic acid, azathioprine, and infliximab failed to achieve clinical remission. A colonoscopy 5 months later revealed a diffusely spreading granular mucosa without visible vasculature, compatible with active ulcerative colitis. Based on these serial changes in colonic lesions, we tested the patient for MEFV gene mutations and found variants E148Q and L110P in exon 2. Administration of colchicine resulted in complete clinical remission. Our experience suggests that drastic changes in the features of colonic inflammation may be a clue to the diagnosis of enterocolitis associated with familial Mediterranean fever.
Developmental cochlear defects are involved in early‐onset hearing loss in A/J mice
Authors: Kui Lihong , Ma Peng , Zhao Wenben , Yan Bin , Kuang Xiaojing , Li Bo , Geng Ruishuang , Zheng Tihua , Zheng Qingyin 
Published: September 2024

AbstractBackgroundA/J mice exhibited a severe hearing loss (HL) at juvenile stage. Up‐to‐date, studies on HL in A/J mice have mostly focused on the damage or dysfunction of hair cells (HCs), spiral ganglion neurons (SGNs), and stereocilia. We examined A/J mice at the early postnatal stage and found that the damage and the loss of outer hair cells (OHCs) are not severe enough to explain the profound HL observed at this age, which suggests that other cochlear defects may be responsible for HL. To better understand the mechanisms of early‐onset HLin A/J mice, we characterized the pathology of the cochlea from postnatal day 3 to day 21.ResultsOur results showed defects in cochlear HC stereocilia and MET channel function as early as 3 days old. We also found abnormal localization and a significant reduction in the number of ribbon synapses in 2‐week‐old A/J mice. There are also abnormalities in the cochlear nerve innervation and terminal swellings in 3‐week‐old A/J mice.ConclusionAll of the abnormalities of cochlear existed in the A/J mice were identified in the juvenile stage and occurred before HCs or auditory nerve loss and was the initial pathological change. Our results suggest that developmental defects and subsequent cochlear degeneration are responsible for early‐onset hearing loss in A/J mice.
Effects of different thermal processing methods on amino acid, fatty acid, and volatile flavor substance contents of Aohan millet (Golden seedling millet)
Authors: Cheng Likun , Qu Shuang , Yun Yueying , Ren Yan , Guo Fucheng , Zhang Yakun , Wang Guoze 
Published: September 2024

AbstractAohan millet has been cultivated for 8000 years and has rich nutritional value, such as high‐quality fatty acids and amino acids. Thermal processing is a conventional approach to food preparation. However, the effect of thermal processing on the formation of flavor substances in millet has not been clarified. Therefore, in this study, the effects of three different thermal processing techniques, namely, steaming, stir‐frying, and puffing, on the amino acids, fatty acids, and volatile flavor substances of Aohan millet were investigated using high‐speed automatic amino acid analyzer, headspace solid‐phase microextraction method, combined with gas chromatography–mass spectrometry (HS‐SPME/GC–MS) and gas chromatography (GC) with Aohan millet from Inner Mongolia as the raw material. All three thermal processing methods notably reduced the levels of protein, starch, polyphenols, and flavonoids in Aohan millet when compared to the raw millet (p < .05). Amino acid and fatty acid contents demonstrated an increase in fried and puffed millet relative to steamed millet, with notable distinctions in amino acid and fatty acid contents between these two groups. Following the steaming process, there was a significant increase in the flavor compounds of Aohan millet, rising from 53 to 80, while this increase was not observed in the other two groups. The correlation analysis suggested that the formation of flavor compounds was predominantly influenced by the types and levels of amino acids. The study suggested that different heat treatments affected the amino acid, fatty acid, and more significantly flavor material content and composition of Aohan millet. In conclusion, steaming treatment could retain more nutrients and richer flavor substances; while puffing treatment would enhance amino acid and fatty acid content, which provides a fundamental basis for scientifically guided processing and rational culinary application of Aohan millet.
Improvement proposals and actions in medication error reports: Quality and strength: A cross‐sectional study
Authors: Valkonen Ville , Haatainen Kaisa , Saano Susanna , Tiihonen Miia 
Published: September 2024

AbstractBackground and AimsMedication errors (MEs) are a significant source of preventable harm in patient care. Voluntary incident reporting and ME reporting systems are essential for managing medication safety. Analyzing aggregated ME reports instead of individual reports can reveal organizational risks. Organizational culture influences reporting activity and the effectiveness of safety improvements depends on their system‐focus. This study uses aggregated ME reports to investigate the ME management process and reporting culture in medication safety. It aims to create a hierarchy for ME improvement actions and analyze their strength and management flow in aggregated reports.MethodsA retrospective, cross‐sectional study was conducted to review improvement proposals and actions of ME reports in a Finnish tertiary hospital in 2017–2021. The improvement proposals and actions were categorized into strength classes during three stages: reporter proposals, manager proposals, and documented actions. The report management flow was analyzed. Descriptive statistics were used to describe the characteristics and the chi‐squared test for categorical variables in the statistical analysis.ResultsA new strength classification hierarchy was created with three classes and corresponding numerical values: “strong (3),” “medium (2),” and “weak (1)” Additionally, categories for “no action (0)” and “vague (0)” were included. Out of 5463 ME reports analyzed, improvement proposals and actions were predominantly weak, ranging from 23.4% to 54.2% across different stages of the management process. A significant proportion had no action included (20.5−49.1%) or were vague (4.2−20.6%).ConclusionAnalyzing the strength of improvement proposals and actions in aggregated ME reports provides new insights into reporting culture and the ME management. The new combined strength classification hierarchy is a suitable tool for this analysis.
Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study
Authors: Ji Chen , Ge Wenjing , Zhu Chen , Shen Fang , Yu Yuhui , Pang Guanlian , Li Qiao , Zhu Mingxuan , Ma Zhimin , Zhu Xia , Fu Yating , Gong Linnan , Wang Tianpei , Du Lingbin , Jin Guangfu , Zhu Meng 
Published: September 2024

AbstractFamily history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow‐up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data (N = 442,399), we constructed PRS and incidence‐weighted overall cancer PRS (CPRS). FH was assessed through self‐reported standardized questions. Among 202,801 men (34.6% with FH) and 239,598 women (42.0% with FH), Cox regression was used to examine the associations between FH, PRS, and cancer risk. We found a significant dose–response relationship between FH of cancer and corresponding cancer risk (Ptrend < .05), with over 10 significant pairs of cross‐cancer effects of FH. FH and PRS are positively correlated and independent. Joint effects of FH of cancer (multiple cancers) and PRS (CPRS) on corresponding cancer risk were observed: for instance, compared with participants with no FH of cancer and low PRS, men with FH of cancer and high PRS had the highest risk of colorectal cancer (hazard ratio [HR]: 3.69, 95% confidence interval [CI]: 3.01–4.52). Additive interactions were observed in prostate and overall cancer risk for men and breast cancer for women, with the most significant result being a relative excess risk of interaction (RERI) of 2.98, accounting for ~34% of the prostate cancer risk. In conclusion, FH and PRS collectively contribute to cancer risk, supporting their combined application in personalized risk assessment and early intervention strategies.
Metabolic regulation of the tumour and its microenvironment: The role of Epstein–Barr virus
Authors: Lee Shen‐Han , Khoo Alan Soo‐Beng , Griffiths John R. , Mat Lazim Norhafiza 
Published: September 2024

AbstractThe Epstein–Barr virus (EBV), the first identified human tumour virus, infects over 95% of the individuals globally and has the potential to induce different types of cancers. It is increasingly recognised that EBV infection not only alters cellular metabolism, contributing to neoplastic transformation, but also utilises several non‐cell autonomous mechanisms to shape the metabolic milieu in the tumour microenvironment (TME) and its constituent stromal and immune cells. In this review, we explore how EBV modulates metabolism to shape the interactions between cancer cells, stromal cells, and immune cells within a hypoxic and acidic TME. We highlight how metabolites resulting from EBV infection act as paracrine factors to regulate the TME, and how targeting them can disrupt barriers to immunotherapy.