bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative Comparative Analysis of exercise interventions for fall prevention in residential aged care facilities
Authors: Suen Jenni , Dawson Rik , Kneale Dylan , Kwok Wing , Sherrington Catherine , Sutcliffe Katy , Cameron Ian D. , Dyer Suzanne M. 
Published: September 2024

Abstract
Background
Exercise interventions are highly effective at preventing falls in older people living in the community. In residential aged care facilities (RACFs), however, the evidence for effectiveness is highly variable, warranting exploration of drivers of successful trials. This study aims to identify the conditions of randomised controlled trials (RCTs) that are associated with reducing falls in RACFs and test whether it can explain the variability.

Methods
RCTs testing exercise interventions in RACFs compared to usual care, reporting rate or risk of falls from the 2018 Cochrane Collaboration review and a search update to December 2022 were included. Two authors independently extracted and coded trial conditions and outcomes according to a theory developed from prior Intervention Component Analysis. Trial outcomes were coded as successful or unsuccessful based on point estimates for the rate or risk ratio for falls, or p value. Qualitative Comparative Analysis (QCA), utilising Boolean minimisation theory, was conducted to determine the key conditions driving trial success. A subgroup meta-analysis and the GRADE approach was applied to the final theory.

Results
Eighteen trials undertaken in 11 countries with 2,287 residents were included. Participants were predominately ambulant females aged 70 to 80 with cognitive impairment. Most interventions were fully supervised or supervised at the start of the intervention. QCA identified two configurations as drivers of successful exercise falls prevention programs: (i) group exercise that is moderate or low intensity, or (ii) for independent ambulatory residents, exercise for more than 1 h per week. The combination of configuration (i) and (ii) had consistency and total coverage scores of 1, indicating all trials were explained. This combination was associated with a reduction in falls (rate ratio 0.45, 95%CI 0.34 to 0.59; risk ratio 0.66, 95%CI 0.53 to 0.82; low certainty evidence).

Conclusion
To successfully reduce falls in RACFs, exercise programs should provide continuous supervised moderate-intensity group exercise. For programs that mostly include independent ambulatory residents, exercise for at least 80 min per week should be provided. As many current residents are frail, tailored exercise is likely necessary and an individualised dose may be required. Future trials should test exercise interventions for less mobile residents.
Trial of labour after two caesarean sections (TOLA2C) and risk of uterine rupture, a retrospective single centre study
Authors: Denjean Sonja , Reis Daniela , Bräuer Miriam , Längler Alfred 
Published: September 2024

Abstract
Background
Most German hospitals do not offer a trial of labour after two caesarean sections (TOLA2C). TOLA2C is claimed to be associated with too many complications, above all the high risk of uterine rupture. The objective of this study is to review our experience with TOLA2C, with special attention paid to the risk and probability of uterine ruptures. Secondary outcomes include comparing neonatal and maternal outcomes in the group of TOLA2C with the group of elective repeat caesarean section (ERCS) and to assess the success rate for vaginal birth after two caesarean sections (VBAC-2).

Methods
The retrospective cohort study was conducted in a community hospital in North Rhine-Westphalia. Inclusion criteria were all pregnant women with two caesarean sections in their medical history, with a current vertex singleton pregnancy and the absence of morphological abnormalities of the foetus, who gave birth in our facility between January 2015 and June 2021. Descriptive statistics were calculated and Kolmogorov-Smirnov tests, Mann-Whitney U tests, Fishers exact tests, Chi2 –tests and t-tests for independent samples were performed.

Results
A total of 91 cases were included in the TOLA2C-group. These were compared to 99 cases that, within the same time frame, had an elective repeat caesarean section (ERCS-group). There was no statistically significant difference found in the neonatal outcome between the two groups (except for the neonatal pH-value: p 0.024). The hospital stay was significantly shorter in the TOLA2C-group, while maternal complication rates were almost similar (13.2% in the TOLA2C-Group, vs. 16.2% in the ERCS-Group). The success rate for TOLA2C was 55%. No complete uterine rupture was found, but in three cases an incomplete rupture (3.3% rate for incomplete uterine ruptures) occurred, but had no influence on the neonatal outcome.

Conclusion
TOLA2C is not associated with a worse maternal or neonatal outcome compared to ERCS, and especially the risk of complete uterine ruptures seems to be low. TOLA2C should be more widely offered to suitable patients who are motivated for it.
CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer
Authors: Guan Yibing , Liu Xueyi , Tian Juanhua , Yang Guang , Xu Fangshi , Guo Ni , Guo Lingyu , Wan Ziyan , Huang Zhixin , Gao Mei , Chong Tie 
Published: September 2024

Abstract
Background
Circulating tumor cells (CTCs) are pivotal in tumor metastasis across cancers, yet their specific role in renal cancer remains unclear.

Methods
This study investigated C–C motif chemokine ligand 5 (CCL5)'s tumorigenic impact on renal cancer cells and CTCs using bioinformatics, in vivo, and in vitro experiments. It also assessed renal cancer patients' CTCs prognostic value through Lasso regression and Kaplan–Meier survival curves.

Results
Bioinformatics analysis revealed differential genes focusing on cellular adhesion and migration between CTCs and tumor cells. CCL5 exhibited high expression in various CTCs, correlating with poor prognosis in renal cancer. In 786-O-CTCs, CCL5 enhanced malignancy, while in renal cell carcinoma cell line CAKI-2 and 786-O, it promoted epithelial-mesenchymal transition (EMT) via smad2/3, influencing cellular characteristics. The nude mouse model suggested CCL5 increased CTCs and intensified EMT, enhancing lung metastasis. Clinical results shown varying prognostic values for different EMT-typed CTCs, with mesenchymal CTCs having the highest value.

Conclusions
In summary, CCL5 promoted EMT in renal cancer cells and CTCs through smad2/3, enhancing the malignant phenotype and facilitating lung metastasis. Mesenchymal-type CTC-related factors can construct a risk model for renal cancer patients, allowing personalized treatment based on metastatic risk prediction.
Comprehensive analysis of an mRNA co-expression network and a ceRNA network reveals potential prognostic biomarkers in oral squamous cell carcinoma
Authors: He Liming , Jiang Zhisheng , Gao Yijun , Zeng Yiyu , Ge Wenhui , Yu Yi , Xie Xiaoyan 
Published: September 2024

Abstract
Background
Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive oral cancer with a poor prognosis. Its polygenic risk is likely influenced by complex transcriptional disorders involving networks of co-expressed and functionally related genes, though such investigations are limited in OSCC.

Methods
We analyzed the GSE37991 dataset, comprising 40 OSCC and 40 normal oral tissue samples from the Gene Expression Omnibus. Tumor-specific modules were identified using weighted correlation network analysis (WGCNA), leading to the selection of hub mRNAs and lncRNAs. These lncRNAs were used to construct lncRNA–mRNA and competing endogenous RNA networks. We further examined the expression profiles and survival data of these genes from the Cancer Genome Atlas. Prognostic markers were identified and validated through 5-year survival analysis and Cox proportional hazards modeling. RT-qPCR was used to validate the expression levels in clinical OSCC tissues.

Results
We identified 1847 differentially expressed genes in OSCC tissues. WGCNA revealed four OSCC-specific modules, screening 120 hub mRNAs and five hub lncRNAs. Two prognostic markers (AQP5, IL-26) from hub mRNAs and three (FRMD5, INHBB, GUCY1A3) from the lncRNA–mRNA network were associated with survival. Validation showed lower expression of AQP5 and GUCY1A3, and higher expression of FRMD5 and INHBB in OSCC compared to normal tissues.

Conclusion
This study enhances our understanding of transcriptional dysregulation in OSCC and may highlights AQP5, IL-26, FRMD5, INHBB, and GUCY1A3 as promising prognostic biomarkers.
Inter-observer reliability and predictive values of triphasic computed tomography for microvascular invasion in hepatocellular carcinoma
Authors: Saleh Gehad A. , Denewar Fatmaelzahraa Abdelfattah , Ali Khadiga M. , Saleh Marwa , Ali Mahmoud Abdelwahab , Shehta Ahmed , Mansour Manar 
Published: September 2024

Abstract
Background
Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor globally and a leading cause of mortality in cirrhotic patients. Our study aimed to estimate the diagnostic performance of triphasic CT and inter-observer reliability in the preoperative detection of microvascular invasion (MVI) in HCC. Two independent radiologists accomplished a retrospective analysis for 99 patients with HCC to assess the CT features for MVI in each lesion. Postoperative histopathology was considered the gold standard.

Results
Multivariate regression analysis revealed that incomplete or absent tumor capsules, presence of TTPV, and absence of hypodense halo were statistically significant independent predictors of MVI. There was excellent agreement among observers in evaluating peritumoral enhancement, identifying intratumoral arteries, hypodense halo, TTPV, and macrovascular invasion. Also, our results revealed moderate agreement in assessing the tumor margin and tumor capsule.

Conclusion
Triphasic CT features of MVI are reliable imaging predictors that may be helpful for standard preoperative interpretation of HCC.
BORBULHANDO ARTEFATOS CULTURAIS EM PROCESSOS EDUCATIVOS NUMA PESQUISA NA EDUCAÇAO INFANTIL:
Authors: Ribeiro Cláudia Maria Ribeiro , Freitas Ila Maria Silva de Souza Mendes de Freitas 
Published: September 2024

Os artefatos culturais, por serem criações humanas, são indiscutivelmente amplos, complexos, diversificados e por isso mesmo valorosos suportes para e nos processos educativos institucionais e não institucionais. Este artigo se propõe a apresentar e discutir três artefatos culturais que borbulharam em três instituições de Educação Infantil com a mediação de educadoras atuantes nessas instituições. O contexto dessa ebulição foi na pesquisa aprovada pela Fapemig intitulada: Políticas Públicas para a Educação Infantil e os processos educativos nos municípios que integram o Fórum Sul Mineiro de Educação Infantil. O material empírico que será problematizado contemplará as experiências das educadoras e crianças: 1. com o filme Divertida Mente, dirigido por Keslsey Mann (2024); 2. um casulo encontrado pelas crianças na área externa de um Centro de Educação Infantil e 3. uma brincadeira com o parto de uma boneca no espaço de uma brinquedoteca. Os referenciais teóricos que subsidiaram essas discussões se inscrevem no âmbito da Sociologia das Infâncias, dos Estudos Culturais e da Filosofia de Gaston Bachelard em relação às questões do Imaginário, da Razão e do Conhecimento, bem como dos Estudos Culturais com ênfase nos artefatos culturais. A criança como sujeito de direitos é um ser em constituição de sua subjetividade e consiste centralidade em nossas reflexões. Também consideramos que a razão e a imaginação, no sentido bachelardiano, são potentes elementos estruturantes e estruturadores da própria condição humana e serão problematizados a partir das experiências advindas da pesquisa em tela.
The SAInT study: a protocol for a randomized controlled trial of steroid injection for subacromial pain syndrome using the anterolateral versus posterior approach
Authors: Charalambous Charalambos P. , Hirst John T. , Kwaees Tariq , Lane Suzanne , Taylor Clare , Solanki Nilesh , Maley Alex , Taylor Rebecca , Howell Laura , Nyangoma Stephen , Martin Francis L. , Khan Maqsood , Choudhry Muhammad N. , Shetty Vishwanath , Malik Rayaz A. 
Published: September 2024

AimsSteroid injections are used for subacromial pain syndrome and can be administered via the anterolateral or posterior approach to the subacromial space. It is not currently known which approach is superior in terms of improving clinical symptoms and function. This is the protocol for a randomized controlled trial (RCT) to compare the clinical effectiveness of a steroid injection given via the anterolateral or the posterior approach to the subacromial space.MethodsThe Subacromial Approach Injection Trial (SAInT) study is a single-centre, parallel, two-arm RCT. Participants will be allocated on a 1:1 basis to a subacromial steroid injection via either the anterolateral or the posterior approach to the subacromial space. Participants in both trial arms will then receive physiotherapy as standard of care for subacromial pain syndrome. The primary analysis will compare the change in Oxford Shoulder Score (OSS) at three months after injection. Secondary outcomes include the change in OSS at six and 12 months, as well as the Pain Numeric Rating Scale (0 = no pain, 10 = worst pain), Disabilities of Arm, Shoulder and Hand questionnaire (DASH), and 36-Item Short-Form Health Survey (SF-36) (RAND) at three months, six months, and one year after injection. Assessment of pain experienced during the injection will also be determined. A minimum of 86 patients will be recruited to obtain an 80% power to detect a minimally important difference of six points on the OSS change between the groups at three months after injection.ConclusionThe results of this trial will demonstrate if there is a difference in shoulder pain and function after a subacromial space steroid injection between the anterolateral versus posterior approach in patients with subacromial pain syndrome. This will help to guide treatment for patients with subacromial pain syndrome.Cite this article: Bone Jt Open 2024;5(9):729–735.
Immobilisation in a collar and cuff with high elbow flexion is a safe and effective treatment option to reduce and immobilise Gartland type II supracondylar fractures
Authors: Yap RY , Bommireddy L , Firth A , Marson BA , Price K , Lawniczak D 
Published: September 2024

Introduction This study aimed to report the proportion of children requiring subsequent surgical intervention, rate of complications and radiologic outcomes following collar and cuff immobilisation with high elbow flexion (>90°) for Gartland type II supracondylar fractures. Methods A retrospective case series of consecutive patients aged <18 years with Gartland type II fractures treated at a level 1 trauma centre from December 2020 to April 2023 was conducted. The need for surgical intervention and complications were recorded from electronic clinical notes. The initial, post-immobilisation and final Baumann's angle and lateral humeral–capitellar angle (LHCA) were measured and compared. Results In total, 42 patients were included in this study. Thirty-four were treated definitively in a collar and cuff with a mean elbow flexion of 109.4°. Two patients underwent closed reduction and Kirschner wire fixation. No patient required subsequent corrective osteotomy. There were no cases of recorded complications. Immobilisation in a collar and cuff with >90° elbow flexion was associated with a significant improvement in the mean LHCA (initial 80.9° vs final 65.6°, p < 0.001). There was no significant change in the LHCA post immobilisation in a collar and cuff until final radiographic follow-up (post immobilisation 68.3° vs final 65.6°, p=0.274). Conclusions Immobilisation in a collar and cuff with high elbow flexion is a safe and effective nonoperative treatment method to reduce and immobilise Gartland type II supracondylar fractures. Surgical treatment could be reserved for cases with unsatisfactory alignment or early loss of reduction following attempted nonoperative treatment.
Cognitive stimulation in activities of daily living for individuals with mild-to-moderate dementia (CS-ADL): Study protocol for a randomised controlled trial
Authors: Ryan Simone M. , Brady Orla 
Published: September 2024

Background
Multi-component CS programs incorporating practice of activities of daily living (ADL) into intervention have reported benefits for ADL outcomes in individuals living with mild-to-moderate dementia. A randomised controlled trial (RCT) within community occupational therapy services in Ireland, is planned to evaluate the effects of CS-ADL, an ADL-focused, multi-component CS program, on ADL outcomes for individuals living with mild-to-moderate dementia.

Method
A single-blind RCT with a calculated sample size of 34 participants has been planned to compare the effects of CS-ADL versus treatment as usual on the outcomes of basic ADLs and instrumental ADLs. Cognition, mood, communication, and quality of life will also be evaluated as secondary outcomes. CS-ADL sessions will run once weekly for a total of seven weeks, lasting approximately two hours each. Outcome data will be collected at baseline, within sessions and post-intervention at week eight. Descriptive statistics will be used to analyse the data. This study has been registered at clinicaltrials.gov (NCT06147479).

Discussion
CS programs are commonly conducted by occupational therapists working with individuals living with mild-to-moderate dementia. This study aims to demonstrate the effectiveness of a multi-component CS program delivered through an occupational therapy lens, potentially influencing the approach to CS and ADL interventions undertaken by occupational therapists.
Collateral assessment on magnetic resonance imaging/angiography up to 30 hours after stroke onset
Authors: Tomari Shinya , Lillicrap Thomas , Garcia-Esperon Carlos , Tomari Kashida Yumi , Bivard Andrew , Lin Longting , Levi Christopher R. , Spratt Neil J. 
Published: September 2024

Purpose
We aimed to validate hyperintense vessel sign (HVS) on FLAIR imaging or posterior cerebral artery (PCA) laterality on MR angiography beyond 4.5 hours after stroke onset.

Materials and methods
Data from acute ischemic stroke patients with internal carotid or middle cerebral artery occlusion who underwent CT perfusion imaging at baseline, follow-up MR perfusion imaging and angiography within 30 hours after stroke, without effective recanalization on follow-up imaging, were analysed retrospectively. Patients were separately classified as high or low HVS (>5 or ≤5 slices of HVS), and PCA laterality positive or negative group. We compared core and penumbra volumes at follow-up imaging and neurological outcomes between high or low HVS group, and between PCA laterality positive or negative group.

Results
Of 49 patients analyzed, four patients with artifacts were excluded and 45 were classified into high (n = 23) or low (n = 22) HVS group. High group had a smaller core volume (median 32 ml versus 109 ml, p = 0.004), larger penumbra volume at follow-up (68 ml versus 0 ml, p = 0.001), and better outcomes (modified Rankin Scale at three months, 3 versus 5, p = 0.03). For PCA laterality analysis, 1 patient with previously occluded PCA was excluded and 48 patients were classified as positive (n = 22) or negative (n = 26). Positive group had larger core volume (116 ml versus 37 ml), and no significant differences in penumbral volumes or outcomes.

Conclusion
Prominent HVS in later time was associated with small core volume, persistent penumbra volume and favorable outcomes.
El presidente de Colombia y su elusión constitucional en época de crisis
Authors: Mendieta David , Gómez-Gómez Juan Fernando 
Published: September 2024

El uso y abuso del estado de sitio en Colombia fue una constante durante los siglos XIX y XX. Por ello, el Constituyente de 1991 fue tan cuidadoso a la hora de regular los estados de excepción estableciendo un sistema de exigentes límites y controles. El objetivo de este escrito es evidenciar que ahora el Presidente colombiano, en épocas de crisis, preferirá usar competencias de rango legal como lo son la emergencia sanitaria y la asistencia militar para limitar derechos humanos en vez de acudir a competencias constitucionalescomo los estados de excepción. A las diferentes formas de elusión constitucional propuestas por Manuel Quinche Ramírez en su texto “La elusión constitucional: una política de evasión del control constitucional en Colombia” tendríamos que agregar una nueva y es aquella realizada por el Presidente en épocas de crisis, al usar actos administrativos para enfrentar situaciones que requieren normas con fuerza de ley. Lo anterior, pues los controles para los decretos de estados de excepción son más exigentes y eficaces que los existentes para los actos administrativos. Con esto se configura un presidencialismo elusivo del control idóneo de constitucionalidad.
The Hand that Touched Troy: Using Maniculae in Latin and French Manuscripts (Benoît de Sainte-Maure’s Roman de Troie, Guido delle Colonne’s Historia and their Respective Prose Versions)
Authors: Tanniou Florence 
Published: September 2024

Abstract
In Auch, BM, 10, more than 120 maniculae, or manicules, touch the text of the Historia destructionis Troiae by Guido delle Colonne with their short or disproportionately long fingers. These maniculae are accompanied by brackets, notae, various remarks. They testify to an active reading of the work, which brushes against the writing as closely as possible, signalling and selecting passages, sometimes simply pointing out, sometimes recopying, summarizing, or commenting. This practice, which was by no means specific to the Trojan material, is far more apparent in manuscripts of the Latin work compared to those of its French source (Benoît de Sainte-Maure) and in the French prose versions that stem directly from it. By examining manuscripts of both the Latin and French traditions, and while also taking into account the methodological biases that this approach implies, this article interprets the presence of reading marks (maniculae, underlining, notes) in Trojan texts. I retrace various types of reading, which include character-focused, historical, moral or rhetorical modes of reading. I demonstrate that specific readerly profiles emerge, and more specifically, that such marks of reading turn out to be topical teaching tools or otherwise present a more subjective interaction with the textual matter. In short, I examine how these hands touching the words might inform our understanding of the reception of Troy during the Middle Ages and the early modern period.
The Traumas of Troy and the Elizabethan Schoolboy in Marlowe’s Dido, Queene of Carthage
Authors: James Heather 
Published: September 2024

Abstract

Dido, Queene of Carthage is calibrated to disrupt the smooth passage of the translation of empire and studies embraced by humanist pedagogy. Taking full advantage of the theatrical affordances offered by the boy actors of the Children of her Majesty’s Chapel, the play aims to whisk its target audience, the sophisticated wits of the Inns of Court, back to their early encounters with the matter of Troy in their studies of Vergil and Ovid in grammar school. This essay focuses on the play’s first two acts to show how Marlowe deploys the materials of classical letters and rhetoric in ways that test and contest their ideological functions.