bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of pharmacologic treatment in cluster A personality disorders
Authors: Koch Jessa , Modesitt Taylor , Palmer Melissa , Ward Sarah , Martin Bobbie , Wyatt Robby , Thomas Christopher 
Published: March 2016

Abstract

Introduction: A personality disorder is a pervasive and enduring pattern of behaviors that impacts an individual's social, occupational, and overall functioning. Specifically, the cluster A personality disorders include paranoid personality disorder, schizoid personality disorder, and schizotypal personality disorder. Patients with cluster A personality disorders tend to be isolative and avoid relationships. The quality of life may also be reduced in these individuals, which provokes the question of how to treat patients with these personality disorders. The purpose of this review is to evaluate the current literature for pharmacologic treatments for the cluster A personality disorders.

Methods: A Medline/PubMed and Ovid search was conducted to identify literature on the psychopharmacology of paranoid personality disorder, schizoid personality disorder, and schizotypal personality disorder. There were no exclusions in terms of time frame from article publication or country of publication, in order to provide a comprehensive analysis; however, only articles that contained information on the cluster A disorders were included.

Results: Minimal evidence regarding pharmacotherapy in paranoid and schizoid personality disorders was found. Literature was available for pharmacologic treatment of schizotypal personality disorder. Studies evaluating the use of olanzapine, risperidone, haloperidol, fluoxetine, and thiothixene did yield beneficial results; however, treatment with such agents should be considered on a case-by-case basis.

Discussion: Most of the literature analyzed in this review presented theoretical ideas of what may constitute the neurobiologic factors of personality and what treatments may address these aspects. Further research is needed to evaluate specific pharmacologic treatment in the cluster A personality disorders. At this time, treatment with pharmacologic agents is based on theory rather than evidence.
Circulating Tumor DNA and Survival in Metastatic Breast Cancer
Authors: Dickinson Kyle , Sharma Archi , Agnihotram Ramana-Kumar Venkata , Altuntur Selin , Park Morag , Meterissian Sarkis , Burnier Julia V. 
Published: September 2024

ImportanceMetastatic breast cancer (MBC) poses a substantial clinical challenge despite advancements in diagnosis and treatment. While tissue biopsies offer a static snapshot of disease, liquid biopsy—through detection of circulating tumor DNA (ctDNA)—provides minimally invasive, real-time insight into tumor biology.ObjectiveTo determine the association between ctDNA and survival outcomes in patients with MBC.Data SourcesAn electronic search was performed in 5 databases (CINAHL, Cochrane Library, Embase, Medline, and Web of Science) and included all articles published from inception until October 23, 2023.Study SelectionTo be included in the meta-analysis, studies had to (1) include women diagnosed with MBC; (2) report baseline plasma ctDNA data; and (3) report overall survival, progression-free survival, or disease-free survival with associated hazards ratios.Data Extraction and SynthesisTitles and abstracts were screened independently by 2 authors. Data were pooled using a random-effects model. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline, and quality was assessed using the Newcastle-Ottawa Scale.Main Outcomes and MeasuresThe primary study outcome was the association between detection of specific genomic alterations in ctDNA with survival outcomes. Secondary objectives were associations of study methodology with survival.ResultsOf 3162 articles reviewed, 37 met the inclusion criteria and reported data from 4264 female patients aged 20 to 94 years. Aggregated analysis revealed a significant association between ctDNA detection and worse survival (hazard ratio, 1.40; 95% CI, 1.22-1.58). Subgroup analysis identified significant associations of TP53 and ESR1 alterations with worse survival (hazard ratios, 1.58 [95% CI, 1.34-1.81] and 1.28 [95% CI, 0.96-1.60], respectively), while PIK3CA alterations were not associated with survival outcomes. Stratifying by detection method, ctDNA detection through next-generation sequencing and digital polymerase chain reaction was associated with worse survival (hazard ratios, 1.48 [95% CI, 1.22-1.74] and 1.28 [95% CI, 1.05-1.50], respectively).Conclusions and RelevanceIn this systematic review and meta-analysis, detection of specific genomic alterations in ctDNA was associated with worse overall, progression-free, and disease-free survival, suggesting its potential as a prognostic biomarker in MBC. These results may help guide the design of future studies to determine the actionability of ctDNA findings.
Molecular Design Strategy for Meta‐Substituted Aromatic Organic Halides in Zero‐Lead‐Release Halide Perovskites with Efficient Waterproof Light Emission
Authors: Jan Pei‐En , Liang Hao‐Chi , Cheng Ren‐Wei , Greve Christopher R. , Chuang Yung‐Tang , Chiu Yung‐Ling , Tan Guang‐Hsun , Elsenety Mohamed M. , Chang Chih‐Li , Dorrah Dalia M. , Lai Hoong‐Lien , Chiu Po‐Wei , Sun Sheng‐Yuan , Li Yun‐Li , Herzig Eva M. , Chou Ho‐Hsiu , Lin Hao‐Wu 
Published: September 2024

AbstractHalide perovskites have received an immense attention in the field of optoelectronics due to their outstanding photophysical properties. But so far, lead‐based halide perovskites still account for most of the research, which raises concerns due to lead toxicity. Herein, a new design strategy is proposed utilizing a super large, energetically higher singlet and triplet energy levels aromatic organic cation to incorporate into the perovskite structure, forming ultra‐stable high‐performance 2D/3D (quasi‐2D) perovskite. The judicious molecular design of connecting all the phenyl groups at their meta sites ensures the simultaneous achievement of a large molecular weight and high singlet and triplet energy levels. The resulting quasi‐2D perovskite thin films not only exhibits excellent emission properties but also, surprisingly, show long‐term waterproof‐level stability. The robustness of these perovskites is confirmed by their extraordinary emission stability upon direct water immersion and almost undetectable lead release in water. Proof‐of‐concept of a water‐resistant color conversion‐type perovskite near‐infrared (NIR) light‐emitting diode (LED) is demonstrated, showing high external quantum efficiency (EQE) and power conversion efficiency (PCE) of 20.5% and 13.3%, respectively. It is believed these results and strategy pave a new way for realizing environmentally friendly lead halide materials and devices.
Advanced High Energy Density Secondary Batteries with Multi‐Electron Reaction Materials
Authors: Zhang Botao , Gao Shengyu , Huang Yongxin , Zhang Ning , Wu Feng , Chen Renjie 
Published: September 2024

AbstractNowadays, various types of electrical facilities and the elevated demand for the wider application of electronic devices in future smart cities are calling for next‐generation batteries of higher energy density, superior rate capability, and extended cycling performance. Multi‐electron systems, based on related reactions and materials, have been considered as promising battery systems for future applications, and massive attempts have been made to achieve their practical use. Therefore, a comprehensive realization of multi‐electron reactions is imperative for the exploitation of innovative multi‐electron materials and steps forward to higher battery performances. In this review, the fundamental conception of multi‐electron reactions and their application bottlenecks are given from both theoretical principles and practice. Multi‐electron materials generally face problems from both thermodynamics and kinetics, including material dissolution, low intrinsic conductivity, low ion transport, etcetera, which seriously hinder their future application. Given all this, current prioritization schemes are summarized, thus making a better understanding of the working mechanisms of the modification methods and inspiring prospects of practical multi‐electron materials.
Structural Ordering in Ultrasmall Multicomponent Chalcogenides: The Case of Quaternary Cu‐Zn‐In‐Se Nanocrystals
Authors: Yarema Maksym , Yazdani Nuri , Yarema Olesya , Đorđević Nikola , Lin Weyde M. M. , Bozyigit Deniz , Volk Sebastian , Moser Annina , Turrini Alexandra , Khomyakov Petr A. , Nachtegaal Maarten , Luisier Mathieu , Wood Vanessa 
Published: September 2024

AbstractThe compositional tunability of non‐isovalent multicomponent chalcogenide thin films and the extent of atomic ordering of their crystal structure is key to the performance of many modern technologies. In contrast, the effects of ordering are rarely studied for quantum‐confined materials, such as colloidal nanocrystals. In this paper, the possibilities around composition tunability and atomic ordering are explored in ultrasmall ternary and quaternary quantum dots, taking I‐III‐VI‐group Cu‐Zn‐In‐Se semiconductor as a case study. A quantitative synthesis for 3.3 nm quaternary chalcogenide nanocrystals is developed and shown that cation and cationic vacancy ordering can be achieved in these systems consisting of only 100s of atoms. Combining experiment and theoretical calculations, the relationship between structural ordering and optical properties of the materials are demonstrated. It is found that the arrangement and ordering of cationic sublattice plays an important role in the luminescent efficiency. Specifically, the concentration of Cu‐vacancy couples in the nanocrystal correlates with luminescence quantum yield, while structure ordering increases the occurrence of such optically active Cu‐vacancy units. On the flip side, the detrimental impact of cationic site disorder in I‐III‐VI nanocrystals can be mitigated by introducing a cation of intermediate valence, such as Zn (II).
Coacervation‐Driven Semipermeable Nanoreactors for Enzymatic Cascade‐Mediated Cancer Combination Therapy with Enhanced Efficacy
Authors: Lin Min , Lv Xueli , Wang Hepeng , Shu Lilei , Wang Helin , Zhang Guojing , Sun Jing , Chen Xuesi 
Published: September 2024

AbstractUtilizing enzyme cascades as a promising approach for targeted cancer therapies holds significant potential, yet its clinical effectiveness is substantially hindered by functional losses during delivery. Complex coacervation emerges as an intriguing strategy for designing functional nanoreactors. In this study, a noteworthy achievement is presented in the development of lactobionic acid‐modified tumor microenvironment (TME)‐responsive polyelectrolyte complex vesicles (HGS‐PCVs) based on bioinspired homopolypeptoids, which serve as a facile, intelligent, and highly efficient nanoreactor tunable for glucose oxidase, hemoglobin, and sorafenib (SRF) to hepatic cancer cells. The TME‐responsive permeability of HGS‐PCVs enables the selective entry of glucose into their interior, triggering an enzymatic cascade reaction within the tumor. This intricate process generates toxic hydroxyl radicals while concurrently lowering the pH. Consequently, this pH shift enhances the SRF release, effectively promoting ferroptosis and apoptosis in the target cancer cells. Further, the administration of the HGS‐PCVs not only initiates immunogenic cell death but also plays a crucial role in inducing the maturation of dendritic cells within lymph nodes. It stimulates an adaptive T‐cell response, a crucial mechanism that contributes to impeding the growth of distant tumors in vivo, demonstrating the promising potential of PCVs for cancer immunotherapy.
Activatable Fluorescence and Bio/Chemiluminescence Probes for Aminopeptidases: From Design to Biomedical Applications
Authors: Wu Xiaofeng , Deng Yu , Xu Ying , Kang Heemin , Hu Jing‐Jing , Yoon Juyoung , Liang Gaolin 
Published: September 2024

AbstractAminopeptidases are exopeptidases that catalyze the cleavage of amino acid residues from the N‐terminal fragment of protein or peptide substrates. Owing to their function, they play important roles in protein maturation, signal transduction, cell‐cycle control, and various disease mechanisms, notably in cancer pathology. To gain better insights into their function, molecular imaging assisted by fluorescence and bio/chemiluminescence probes has become an indispensable method to their superiorities, including excellent sensitivity, selectivity, and real‐time and noninvasive imaging. Numerous efforts are made to develop activatable probes that can effectively enhance efficiency and accuracy as well as minimize the side effects. This review is classified according to the type of aminopeptidases, summarizing some recent works on the design, work mechanism, and sensing, imaging, and theranostic performance of their activatable probe. Finally, the current challenges are outlined in developing activatable probes for aminopeptidases and provide possible solutions for future advancements.
Multidentate Fullerenes Enable Tunable and Robust Interfacial Bonding for Efficient Tin‐Based Perovskite Solar Cells
Authors: Sun Chao , Zhang Hui , Cheng Shuo , Chen Jingfu , Xing Yiming , Nan Ziang , Yang Panpan , Wang Ying , Zhao Xinjing , Xie Liqiang , Tian Chengbo , Wei Zhanhua 
Published: September 2024

AbstractImproving the efficiency of tin‐based perovskite solar cells (TPSCs) is significantly hindered by energy level mismatch and weak interactions at the interface between the tin‐based perovskite and fullerene‐based electron transport layers (ETLs). In this study, four well‐defined multidentate fullerene molecules with 3, 4, 5, and 6 diethylmalonate groups, labeled as FM3, FM4, FM5, and FM6 are synthesized, and employed as interfacial layers in TPSCs. It is observed that increasing the number of functional groups in these fullerenes leads to shallower lowest unoccupied molecular orbital (LUMO) energy levels and enhance interfacial chemical interactions. Notably, FM5 exhibits a suitable energy level and robust interaction with the perovskite, effectively enhancing electron extraction and defect passivation. Additionally, the unique molecular structure of FM5 allows the exposed carbon cage to be tightly stacked with the upper fullerene cage after interaction with the perovskite, facilitating efficient charge transfer and protecting the perovskite from moisture and oxygen damage. As a result, the FM5‐based device achieves a champion efficiency of 15.05%, significantly surpassing that of the PCBM‐based (11.77%), FM3‐based (13.54%), FM4‐based (14.34%), and FM6‐based (13.75%) devices. Moreover, the FM5‐based unencapsulated device exhibits excellent stability, maintaining over 90% of its initial efficiency even after 300 h of air exposure.
SHP2‐Triggered Endothelial Cell Activation Fuels Estradiol‐Independent Endometrial Sterile Inflammation
Authors: Pan Jie , Qu Jiao , Fang Wen , Zhao Lixin , Zheng Wei , Zhai Linhui , Tan Minjia , Xu Qiang , Du Qianming , Lv Wen , Sun Yang 
Published: September 2024

AbstractSterile inflammation occurs in various chronic diseases due to many nonmicrobe factors. Examples include endometrial hyperplasia (EH), endometriosis, endometrial cancer, and breast cancer, which are all sterile inflammation diseases induced by estrogen imbalances. However, how estrogen‐induced sterile inflammation regulates EH remains unclear. Here, a single‐cell RNA‐Seq is used to show that SHP2 upregulation in endometrial endothelial cells promotes their inflammatory activation and subsequent transendothelial macrophage migration. Independent of the initial estrogen stimulation, IL1β and TNFα from macrophages then create a feedforward loop that enhances endothelial cell activation and IGF1 secretion. This endothelial cell–macrophage interaction sustains sterile endometrial inflammation and facilitates epithelial cell proliferation, even after estradiol withdrawal. The bulk RNA‐Seq results and phosphoproteomic analysis show that endothelial SHP2 mechanistically enhances RIPK1 activity by dephosphorylating RIPK1Tyr380. This event activates downstream activator protein 1 (AP‐1) and instigates the inflammation response. Furthermore, targeting SHP2 using SHP099 (an allosteric inhibitor) or endothelial‐specific SHP2 deletion alleviates endothelial cell activation, macrophage infiltration, and EH progression in mice. Collectively, the findings demonstrate that SHP2 mediates the transition of endothelial activation from estradiol‐driven acute inflammation to macrophage‐amplified chronic inflammation. Targeting sterile inflammation mediated by endothelial cell activation is a promising strategy for nonhormonal intervention in estrogen‐related diseases.
Engineered Cell Elongation Promotes Extracellular Electron Transfer of Shewanella Oneidensis
Authors: Li Feng , Yu Huan , Zhang Baocai , Hu Chaoning , Lan Fei , Wang Yuxuan , You Zixuan , Liu Qijing , Tang Rui , Zhang Junqi , Li Chao , Shi Liang , Li Wen‐Wei , Nealson Kenneth H. , Liu ZhanYing , Song Hao 
Published: September 2024

AbstractTo investigate how cell elongation impacts extracellular electron transfer (EET) of electroactive microorganisms (EAMs), the division of model EAM Shewanella oneidensis (S. oneidensis) MR‐1 is engineered by reducing the formation of cell divisome. Specially, by blocking the translation of division proteins via anti‐sense RNAs or expressing division inhibitors, the cellular length and output power density are all increased. Electrophysiological and transcriptomic results synergistically reveal that the programmed cell elongation reinforces EET by enhancing NADH oxidation, inner‐membrane quinone pool, and abundance of c‐type cytochromes. Moreover, cell elongation enhances hydrophobicity due to decreased cell‐surface polysaccharide, thus facilitates the initial surface adhesion stage during biofilm formation. The output current and power density all increase in positive correction with cellular length. However, inhibition of cell division reduces cell growth, which is then restored by quorum sensing‐based dynamic regulation of cell growth and elongation phases. The QS‐regulated elongated strain thus enables a cell length of 143.6 ± 40.3 µm (72.6‐fold of that of S. oneidensis MR‐1), which results in an output power density of 248.0 ± 10.6 mW m−2 (3.41‐fold of that of S. oneidensis MR‐1) and exhibits superior potential for pollutant treatment. Engineering cellular length paves an innovate avenue for enhancing the EET of EAMs.
Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver
Authors: Wang Shiguan , Xu Bowen , Liang Jinyuan , Feng Yawei , Han Penghu , Shen Jing , Li Xinying , Zheng Mengqi , Zhang Tingguo , Zhang Cuijuan , Mi Ping , Zhang Yi , Liu Zhiping , Li Shiyang , Yuan Detian 
Published: September 2024

AbstractSpatial heterogeneity and plasticity of the mammalian liver are critical for systemic metabolic homeostasis in response to fluctuating nutritional conditions. Here, a spatially resolved transcriptomic landscape of mouse livers across fed, fasted and refed states using spatial transcriptomics is generated. This approach elucidated dynamic temporal‐spatial gene cascades and how liver zonation—both expression levels and patterns—adapts to shifts in nutritional status. Importantly, the pericentral nuclear receptor Nr1i3 (CAR) as a pivotal regulator of triglyceride metabolism is pinpointed. It is showed that the activation of CAR in the pericentral region is transcriptionally governed by Pparα. During fasting, CAR activation enhances lipolysis by upregulating carboxylesterase 2a, playing a crucial role in maintaining triglyceride homeostasis. These findings lay the foundation for future mechanistic studies of liver metabolic heterogeneity and plasticity in response to nutritional status changes, offering insights into the zonated pathology that emerge during liver disease progression linked to nutritional imbalances.
CO‐Free Aminocarbonylation of Terminal Alkynes Catalyzed by Synergistic Effect From Metal–Organic Frameworks
Authors: Zhao Jian , Zhang Tianze , Xu Hang , Hou Sheng‐Li , Ren Fang‐Yu , Han Jie , Zhao Bin 
Published: September 2024

AbstractIncorporation of CO into substrates to construct high‐value carbonyl compounds is an intensive industrial carbonylation procedure, however, high toxicity and wide explosion limits (12.5–74.0 vol% in air) of CO limit its application in industrial production. The development of a CO‐free catalytic system for carbonylation is one of ideal methods, but full of challenge. Herein, this study reports the CO‐free aminocarbonylation conversion of terminal alkynes synergistically catalyzed by a unique Co(ІІ)/Ag(І) metal–organic framework (MOF), in which the combination of isocyanides and O2 is employed as safe and green source of aminocarbonyl. This reaction has broad substrate applicability in terminal alkyne and isocyanides components with 100% atom economy. The bimetal MOF catalyst can be recycled at least five times without substantial loss of catalytic activities. Mechanistic investigations demonstrate that the synergistic effect between Ag(I) and Co(II) sites can efficiently activate terminal alkyne and isocyanides, respectively. Free radical capture experiments, FT‐IR analysis and theoretical explorations further reveal that terminal alkynes and isocyanides can be catalytically transformed into an anionic intermediate through heterolysis pathways. This work provides secure and practical access to carbonylation as well as a new approach to aminocarbonylation of terminal alkynes.
Configurable Synaptic and Stochastic Neuronal Functions in ZnTe‐Based Memristor for an RBM Neural Network
Authors: Heo Jungang , Kim Seongmin , Kim Sungjun , Kim Min‐Hwi 
Published: September 2024

AbstractThis study presents findings that demonstrate the possibility of simplifying neural networks by inducing multifunctionality through separate manipulation within a single material. Herein, two‐terminal memristor W/ZnTe/W devices implemented a multifunctional memristor comprising a selector, synapse, and a neuron using an ovonic threshold switching material. By setting the low‐current level (µA) in the forming process, a stable memory‐switching operation is achieved, and the capacity to implement a synapse is demonstrated based on paired‐pulse facilitation/depression, potentiation/depression, spike‐amplitude‐dependent plasticity, and spike‐number‐dependent plasticity outcomes. Based on synaptic behavior, the Modified National Institute of Standards and Technology database image classification accuracy is up to 90%. Conversely, by setting the high‐current level (mA) in the forming process, the stable bipolar threshold switching operation and good selector characteristics (300 ns switching speed, free‐drift, recovery properties) are demonstrated. In addition, a stochastic neuron is implemented using the stochastic switching response in the positive voltage region. Utilizing stochastic neurons, it is possible to create a generative restricted Boltzmann machine model.