bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination and correlation of solubility and dissolution thermodynamics of m‐toluic acid and isophthalic acid in binary (water plus ethanoic acid) solvent mixtures
Authors: Lyu Quanming , Zhang Wenbo , Sun Weizhen , Xu Zhimei , Zhao Ling 
Published: December 2017

AbstractThe solubilities of m‐toluic acid (m‐TA) from 313.2 to 383.2 K, as well as those of isophthalic acid (IPA) from 373.2 to 463.2 K in water, ethanoic acid, and their mixtures were measured by the steady‐state method. The modified Apelblat equation was used to correlate the experimental solubilities of m‐TA, as well as those of IPA. The F‐test shows that the modified Apelblat equation is suitable to model the solubilities of m‐TA and IPA, respectively. Based on the determined solubility data, the thermodynamic parameters including the apparent molar enthalpy and entropy concerning solute dissolution were further calculated. We hope that the solubility data and related thermodynamic parameters can provide valuable insights into the design and optimization of the industrial manufacture of IPA.
B cell‐specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans
Authors: Reshetnikova Evdokiya , Guselnikov Sergey , Volkova Olga , Baranov Konstantin , Taranin Alexander , Mechetina Ludmila 
Published: December 2017

BackgroundFc receptor‐like A (FCRLA) is a unique member of a family of Fc receptor like‐molecules that lacks a transmembrane region and is an ER‐resident protein. In mice and humans, FCRLA has been known as a B cell specific protein. We report here that, in humans, FCRLA is also expressed in a subpopulation of plasmacytoid dendritic cells (pDCs).MethodsHuman peripheral blood mononuclear cells (PBMC), splenocytes, and tonsillar cells were stained for lineage markers followed by fixation/saponin permeabilization and intracellular staining for FCRLA, and then analyzed by flow cytometry with CD123 and CD303 used as pDC markers.ResultsWe conducted an extensive flow cytometric analysis of a rare population of CD19‐FCRLA+ cells found for the first time in human lymphoid tissues that we assigned to pDCs as they were lin‐/CD123+/CD303+. FCRLA expression in human pDCs was further confirmed by the RT‐PCR analysis of cDNA of pDCs isolated from the peripheral blood of a healthy donor. FCRLA‐positive pDCs expressed a lower level of HLA‐DR than their FCRLA‐negative counterparts.ConclusionsFCRLA has long been viewed as a B cell specific protein, and this is the first time its expression has also been shown in human pDCs. © 2017 International Clinical Cytometry Society
Headband‐Type Near‐Infrared Spectroscopy Device for Measuring Oxyhemoglobin in Frontal Cortex
Authors: MIYAKE YASUHIRO , HISAKA MASAKI , KITA MITSUHIRO , MATSUMURA MASAFUMI 
Published: December 2017

SUMMARYNear‐infrared spectroscopy (NIRS) is an important technique that percutaneously and noninvasively monitors the changes in hemoglobin concentration of cerebral blood flow. We have developed headband‐type NIRS devices using a light‐emitting diode (LED) power source and a photodiode detector (PD) to reduce the burden in diagnosis preparation and the price of the NIRS module. The 10‐channel non‐real‐time headband‐type NIRS device with PD and one‐package three‐wavelength LED as well as the two‐channel real‐time wireless NIRS headband that is controlled using a tablet PC were manufactured in‐house. The two developed headband NIRS devices were evaluated using an existing LABNIRS system using a verbal fluency task, and they exhibited the same tendency with NIRS signals of the different levels at the rest and task stages. The measurement of the real‐time NIRS signals revealed that the voice and breath caused the source of low‐frequency fluctuations superimposed on the NIRS signals.
Hazard assessment of the pesticides KRAFT 36 EC and SCORE in a tropical natural soil using an ecotoxicological test battery
Authors: de Menezes Oliveira Vanessa Bezerra , de Oliveira Bianchi Miriam , Espíndola Evaldo Luiz Gaeta 
Published: December 2017

Abstract

Pesticides are widely used in agricultural fields to control plant diseases, weeds, and pests; however, the unforeseeable consequences of releasing these compounds into the soil and their effects on terrestrial invertebrates are matters of grave concern. The aim of the present study was to determine the direct impact of 2 pesticides, KRAFT® 36 EC (an insecticide; a.i. abamectin) and SCORE® (a fungicide; a.i. difenoconazole), on nontarget terrestrial invertebrates. Ecotoxicological tests were performed to evaluate the chronic and acute toxicity of these compounds to a potworm (Enchytraeus crypticus), a collembolan (Folsomia candida), and a mite (Hypoaspis aculeifer). The results showed that, for both pesticides, the collembolan F. candida was the most sensitive species, followed by the enchytraeid E. crypticus and the mite H. aculeifer. Effect concentrations at 50% of organisms’ reproduction calculated for F. candida, E. crypticus, and H. aculeifer were 0.06, 2.8, and &gt;32 mg of abamectin/kg dry weight soil and 28.9, 125, and 145.5 mg of difenoconazole/kg dry weight soil, respectively. Environmentally relevant concentrations of both pesticides significantly affected the collembolan species. The existence of a potential risk from abamectin and difenoconazole for soil invertebrates even at recommended doses could be identified. Environ Toxicol Chem 2018;37:2919–2924. © 2017 SETAC
Implementation of repeat HIV testing during pregnancy in southwestern Kenya: progress and missed opportunities
Authors: Rogers Anna J , Akama Eliud , Weke Elly , Blackburn Justin , Owino George , Bukusi Elizabeth A , Oyaro Patrick , Kwena Zachary A , Cohen Craig R , Turan Janet M 
Published: December 2017

AbstractIntroductionRepeat HIV testing during the late antenatal period is crucial to identify and initiate treatment for pregnant women with incident HIV infection to prevent perinatal HIV transmission and keep mothers alive. In 2012, the Kenya Ministry of Health adopted international guidelines suggesting that pregnant women be offered retesting three months after an initial negative HIV test. Our objectives were to determine the current rate of antenatal repeat HIV testing; identify successes, missed opportunities and factors associated with retesting; and estimate the incidence of HIV during pregnancy.MethodsRetrospective analysis of longitudinal data was conducted for a cohort of 2145 women attending antenatal care clinic at a large district hospital in southwestern Kenya. Data were abstracted from registers for all women who attended the clinic from the years 2011 to 2014.ResultsAlthough 90.2% of women first came to clinic prior to their third trimester and 27.5% had at least four clinic visits, 58.0% of all women went to delivery without a retest. Missed opportunities for retesting included not returning to clinic at all, not returning when eligible, or late gestational age (>28 weeks) at first clinic visit making them ineligible for retesting (accounting for 14.2%, 26.8% and 9.6% of all clinic attendees respectively); and failure to be retested even when eligible at one or more visits (accounting for 73.2% of eligible returnees). Being unmarried and aged 20 or younger was associated with an increase in mean gestational age of first visit by 2.52 weeks (95% CI: 1.56, 3.48) and a 2.59 increased odds (95% CI: 1.90, 3.54) of failing to return to clinic, compared to those who were married and over 20 years of age. On retest, two women tested HIV positive, suggesting an incidence rate of 4.4 per 100 person‐years. After adjusting for potential confounders, only later year of last menstrual period (2013 vs. 2012 and 2011) was associated with retesting.ConclusionsAdoption of retesting guidelines in 2012 appears to have successfully increased retesting rates, but missed opportunities to identify incident HIV infection during pregnancy may contribute to continuing high rates of perinatal HIV transmission in southwestern Kenya.
Free‐electron Optical Nonlinearities in Plasmonic Nanostructures: A Review of the Hydrodynamic Description
Authors: Krasavin Alexey V. , Ginzburg Pavel , Zayats Anatoly V. 
Published: December 2017

AbstractRequirements of integrated photonics and miniaturisation of optical devices demand efficient nonlinear components not constrained by conventional macroscopic nonlinear crystals. Intrinsic nonlinear response of free carriers in plasmonic materials provides opportunities to design both second‐ and third‐order nonlinear optical properties of plasmonic nanostructures and control light with light using Kerr‐type nonlinearities as well as achieve harmonic generation. This review summarises principles of free‐carrier nonlinearities in the hydrodynamic description in both perturbative and non‐perturbative regimes, considering also contribution of nonlocal effects. Engineering of harmonic generation, solitons, nonlinear refraction and ultrafast all‐optical switching in plasmonic nanostructures and metamaterials are discussed. The full hydrodynamic consideration of nonlinear dynamics of free carriers reveals key contributions to the nonlinear effects defined by the interplay between a topology of the nanostructure and nonlinear response of the fermionic gas at the nanoscale, allowing design of high effective nonlinearities in a desired spectral range. Flexibility and unique features of free‐electron nonlinearities are important for nonlinear plasmonic applications in free‐space as well as integrated and quantum nanophotonic technologies.
Spatio‐temporal‐dependent errors of radar rainfall estimates in flood forecasting for the Nam River Dam basin
Authors: Ko Dasang , Lee Taesam , Lee Dongryul 
Published: December 2017

ABSTRACTIn flood prediction, radar rainfall estimates have been widely used for calculating approximate rainfall amounts and predicting flood risks. However, radar rainfall estimates have a number of errors, such as beam blockage and ground clutter, that hinder their application in hydrological flood forecasting. Even though previous studies have focused on removing radar data error, it is important to evaluate runoff volume, which is primarily influenced by such radar errors. Furthermore, correlation structures including temporal as well as spatially dependent errors have not been thoroughly studied. Therefore, how those radar rainfall estimate errors influence flood forecasting was tested in this paper by using a spatio‐temporal error model (STEM), which is a cross‐correlation model of radar error. Rainfall‐runoff simulations were conducted with radar rainfall events generated using the STEM to investigate the response in a basin. The Nam River basin, South Korea, was the focus of the study. A distributed rainfall runoff model, Vflo™, was used for runoff simulation. The spatial and temporal resolutions were 0.5 km and 10 min, respectively. The results indicated that a strong correlation caused a higher variation in the peak discharge. It is concluded that the STEM effectively represents the radar rainfall profile. The spatio‐temporal error (STE) of the radar rainfall estimates caused much higher uncertainty in rainfall runoff than only spatial error. To reduce uncertainty in flood prediction using radar rainfall estimates, it is important to eliminate the STE from those estimates.
Application of Generative Autoencoder in De Novo Molecular Design
Authors: Blaschke Thomas , Olivecrona Marcus , Engkvist Ola , Bajorath Jürgen , Chen Hongming 
Published: December 2017

AbstractA major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning methodology, for de novo molecular design. Various generative autoencoders were used to map molecule structures into a continuous latent space and vice versa and their performance as structure generator was assessed. Our results show that the latent space preserves chemical similarity principle and thus can be used for the generation of analogue structures. Furthermore, the latent space created by autoencoders were searched systematically to generate novel compounds with predicted activity against dopamine receptor type 2 and compounds similar to known active compounds not included in the trainings set were identified.
Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy
Authors: Zhu Huang , Lai Yi-Shin , Li Ye , Blum Robert H. , Kaufman Dan S. 
Published: December 2017

AbstractHuman pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers.
MVP and Instructional Systems Design in Online Courses
Authors: Franklin Jennifer L. 
Published: December 2017

AbstractThis chapter is based on three premises. The first premise is that the use of instructional systems design (ISD) methods is important in online as well as traditional classroom settings. A second premise is that improving the motivational design of instruction brings benefits to teachers and learners alike. The third premise, specific to this chapter, is that new technologies and the online environment offer opportunities for enhancing motivation, volition, and performance (MVP) as described by John M. Keller in Chapter 1 of this issue.
Tree-Based Unrooted Phylogenetic Networks
Authors: Francis A. , Huber K. T. , Moulton V. 
Published: December 2017

Abstract
Phylogenetic networks are a generalization of phylogenetic trees that are used to represent non-tree-like evolutionary histories that arise in organisms such as plants and bacteria, or uncertainty in evolutionary histories. An unrooted phylogenetic network on a non-empty, finite set X of taxa, or network, is a connected, simple graph in which every vertex has degree 1 or 3 and whose leaf set is X. It is called a phylogenetic tree if the underlying graph is a tree. In this paper we consider properties of tree-based networks, that is, networks that can be constructed by adding edges into a phylogenetic tree. We show that although they have some properties in common with their rooted analogues which have recently drawn much attention in the literature, they have some striking differences in terms of both their structural and computational properties. We expect that our results could eventually have applications to, for example, detecting horizontal gene transfer or hybridization which are important factors in the evolution of many organisms.
Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
Authors: Zeng Lin‐Shu , Huang Wen‐Ting , Qiu Tian , Shan Ling , Guo Lei , Ying Jian‐Ming , Lyu Ning , Feng Xiao‐Li 
Published: December 2017

AbstractObjectiveTo investigate the correlation between the clinicopathological features and prognosis in patients with extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL).MethodsOne hundred and four patients diagnosed with ENKTCL at the Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China from November 1991 to September 2011 were included in the study. The clinicopathological features and their correlations with disease prognosis were evaluated in these patients.ResultsThe number of effective follow‐up cases was 56 (53.8%) by the end of last follow‐up in October 2015. Univariate survival analysis showed that granzyme B, perforin, and Bcl‐2 expression was significantly associated with a poor prognosis in ENKTCL (P = 0.033, 0.004, and 0.034, respectively), whereas platelet‐derived growth factor receptor‐alpha (PDGFRA) expression was significantly associated with a better prognosis (P = 0.034). Ki‐67 overexpression (≥50%) was significantly associated with a poor prognosis (P = 0.017). Different treatment approaches were also associated with prognosis (P = 0.014); specifically, the efficacies of combination treatments including chemotherapy and radiotherapy, and autologous hematopoietic stem cell transplantation were significantly better than those involving radiotherapy and chemotherapy alone. Patient gender, age, tumor location, staging, the presence of B symptoms, pretreatment lactate dehydrogenase levels, and β2‐microglobulin levels were not associated with the prognosis of ENKTCL (P > 0.05). However, multivariate analyses showed that the treatment approach and all the immune markers were not independent prognostic factors for ENKTCL.ConclusionGranzyme B, perforin, and Bcl‐2 expression and Ki‐67 overexpression (≥50%) might be adverse prognostic factors for ENKTCL, whereas PDGFRA‐positivity suggested a better disease prognosis. In addition, different treatment approaches might be closely related to patient prognosis.
Philosopher's disease and its antidote: Perspectives from prenatal behavior and contagious yawning and laughing
Authors: Provine Robert R. 
Published: December 2017

AbstractAccounts of behavior, including imitation, often suffer from philosopher's disease: the unnecessary, inappropriate, theoretically driven explanation of behavior in terms of cognition, rationality, and consciousness. Embryos are perversely unphilosophical and unpsychological, starting to move before they receive sensory input. Postnatal contagious yawning and laughing indicate that pseudo-imitative behavior can occur without conscious intent or other higher-order cognitive process.
Beyond sensorimotor imitation in the neonate: Mentalization psychotherapy in adulthood
Authors: Desseilles Martin 
Published: December 2017

AbstractDespite the persuasiveness of Keven & Akins' (K&A) review, we argue that mentalization, or the ability to interpret the mental states of oneself and others, is required to construct the neonate mind, going far beyond sensorimotor imitation. This concept, informed by certain psychoanalytic and attachment theories, has produced a form of therapy called mentalization-based psychotherapy, which aims to improve emotional regulation. Our aim here is to shed light on a form of neonatal imitation that goes beyond sensorimotor imitation.
“It takes two to know one” – Tongue protrusion-retraction is only one small facet of early intersubjectivity
Authors: Aitken Kenneth J. 
Published: December 2017

AbstractTongue protrusion-retraction is critical to early nutrition but is also a gustatory-olfactory aspect of early infant social behaviour that is, in part, reliant on pre-natal exposure and learning. Most early development is necessarily dyadic and intrinsically associated with other aspects of social functioning.
There is no compelling evidence that human neonates imitate
Authors: Kennedy-Costantini Siobhan , Oostenbroek Janine , Suddendorf Thomas , Nielsen Mark , Redshaw Jonathan , Davis Jacqueline , Clark Sally , Slaughter Virginia 
Published: December 2017

AbstractKeven & Akins (K&A) propose that neonatal “imitation” is a function of newborns' spontaneous oral stereotypies and should be viewed within the context of normal aerodigestive development. Their proposal is in line with the result of our recent large longitudinal study that found no compelling evidence for neonatal imitation. Together, these works prompt reconsideration of the developmental origin of genuine imitation.
“What” matters more than “Why” – Neonatal behaviors initiate social responses
Authors: Libertus Klaus , Libertus Melissa E. , Einspieler Christa , Marschik Peter B. 
Published: December 2017

AbstractNewborns are born into a social environment that dynamically responds to them. Newborn behaviors may not have explicit social intentions but will nonetheless affect the environment. Parents contingently respond to their child, enabling newborns to learn about the consequences of their behaviors and encouraging the behavior itself. Consequently, newborn behaviors may serve both biological and social-cognitive purposes during development.
Do innate stereotypies serve as a basis for swallowing and learned speech movements?
Authors: Mayer Connor , Roewer-Despres Francois , Stavness Ian , Gick Bryan 
Published: December 2017

AbstractKeven & Akins suggest that innate stereotypies like TP/R may participate in the acquisition of tongue control. This commentary examines this claim in the context of speech motor learning and biomechanics, proposing that stereotypies could provide a basis for both swallowing and speech movements, and provides biomechanical simulation results to supplement neurological evidence for similarities between the two behaviors.
Beyond aerodigestion: Exaptation of feeding-related mouth movements for social communication in human and nonhuman primates
Authors: Murray Lynne , Sclafani Valentina , Rayson Holly , De Pascalis Leonardo , Bozicevic Laura , Ferrari Pier Francesco 
Published: December 2017

AbstractThree arguments are advanced from human and nonhuman primate infancy research for the exaptation of ingestive mouth movements (tongue protrusion and lip smacking) for the purposes of social communication: their relation to affiliative behaviours, their sensitivity to social context, and their role in social development. Although these behaviours may have an aerodigestive function, such an account of their occurrence is only partial.
The dynamic pattern ofPLIN3in pig oocytes and cumulus cells duringin vitromaturation
Authors: Xu Mingzhu , Zeng Yaqiong , Chi Daming , Si Linan , Qu Xiao , Li Juan 
Published: December 2017

SummaryLipid droplets (LDs) are the main energy resource for porcine preimplantation embryonic development.PLIN3has been implicated in LD formation and regulation. Therefore, this study aimed to detect the dynamic pattern ofPLIN3in pig oocytes and cumulus cells (CC) duringin vitromaturation (IVM), and to determine the relationship betweenPLIN3and LD content. IVM with cumulus-enclosed oocytes (CEO), cumulus-denuded oocytes (DO) and the CCs denuded from the corresponding oocytes (DCC) was performed in porcine follicular fluid (PFF) or PFF-free optimized medium. DO and the DCC were cultured together under the same conditions as described above, while the DO was named DTO and the DCC was named DTCC in this group. Firstly, our results revealed LDs distributed widely in oocytes and CC, while thePLIN3protein coated these LDs and spread out ubiquitously in the cytoplasm. Secondly, not only the mRNA level but also at protein level ofPLIN3in immature naked oocytes (IO) was higher than that in matured CEO, DO and DTO. AlthoughPLIN3was expressed at lower levels in CC from immature oocytes (ICC), the protein level ofPLIN3was comparably higher in the ECC and DCC groups. The triglyceride (TG) content in CEO and DO was significantly less abundant compared with that in IO. Therefore, our results indicated that co-culturing of oocytes and CC might affectPLIN3expression levels in CC but not in oocytes. Lipid accumulation in pig oocytes during maturation might be affected byPLIN3cross-talk between oocytes and CC.