bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A79: Influence of culture and religion on fatalistic cancer beliefs
Authors: Farr Deeonna E. , Brandt Heather M. , Friedman Daniela B. , Armstead Cheryl A. , Heiney Sue P. , Adams Swann A. , Green Wanda , Hébert James R. 
Published: March 2017

Abstract
Background Cancer-related beliefs, including cancer fatalism, have been shown to influence Blacks' adherence to cancer screening behaviors. Healthcare discrimination, religious beliefs, income, and education are known determinants of cancer fatalism, however, it is unclear whether other cultural and cancer-related beliefs and/or experiences play a role in fatalistic beliefs. Purpose To determine how sociodemographic characteristics, cancer-related and cultural beliefs contribute to cancer fatalism in a sample of Black adults. Methods A statewide survey was completed by 194 Black adults ≥18 years without a history of cancer from November 2014-July 2015. Sociodemographic characteristics, cancer worry, perceived cancer risk, knowing someone with cancer, mistrust in the medical system, present orientation, religious identity, and religious behaviors were assessed through the survey. Cancer fatalism was measured using a revised version of the Powe Fatalism Inventory. Multiple regression was used to analyze survey data. Results Regression analyses on 131 surveys with complete responses showed that age, income, possessing health insurance, having a present orientation, and engaging in prayer were significant predictors of fatalistic cancer beliefs (R2= 0.26, p&lt;0.05). Discussion The results support some previously established influences on cancer fatalism; however, other influences, specifically medical mistrust, religious identification, and church attendance did not predict cancer fatalism. Cancer fatalism is not directly related to religion but may be indirectly associated with religious practices that indicate a high external locus of control. Examining the contributors of cancer-related beliefs may yield valuable information that can enhance culturally appropriate cancer communication and programming.
Citation Format: Deeonna E. Farr, Heather M. Brandt, Daniela B. Friedman, Cheryl A. Armstead, Sue P. Heiney, Swann A. Adams, Wanda Green, James R. Hébert. Influence of culture and religion on fatalistic cancer beliefs. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr A79.
Abstract B09: Multivariable Models for Predicting Likely Metastatic Sites for Triple Negative Breast Cancers
Authors: Klimov Sergey , Green Andrew , Aleskandarany Mohammed , Rakha Emad , Ellis Ian , Reid Michelle , Padmashree Rida C. G. , Aneja Ritu 
Published: March 2017

Abstract
Background: Unique organ microenvironment may preferentially support growth of specific tumor clones because of which different breast cancer subtypes show distinct tropisms for sites of metastasis. While a few gene expressionbased signatures are known to predict sitespecific metastasis of breast cancer, little work has focused on identification of clinically facile immunohistochemical predictors of metastasis to specific sites, especially for triple negative breast cancers (TNBCs).
Methods: Primary tumor samples from 322 TNBC patients were stained for 133 biomarkers and assessed by immunohistochemistry. Differences in average levels of these biomarkers were compared between patients with or without metastasis to specific sites (brain, bone, lungs, liver, lymph nodes). Significantly different biomarkers were then analyzed within a Cox regression model to evaluate their prognostic value when patients with metastasis to the site of interest were compared to patients with no metastasis. Ideal thresholds, based on maximizing model fit, stratified cohorts that show high and low expression of each biomarker. A combination of a biomarker found high for each site, low for each site, and the Nottingham Prognostic Index (NPI) was used to stratify patients.
Results: Our analysis uncovered several biomarkers whose expression levels in primary tumors can predict the site of future metastasis in TNBCs. Our models for brain (PARP1 & BRCA2), bone (MTA1 &Tumor-Adjacent CD8), liver (TFF1 & N-Cadherin), and lung (ROR) were able to identify patients who had at least a 500% risk of site specific distant metastasis.
Conclusion: Relatively simple and inexpensive immunohistochemical analyses of biomarkers, combined with logical model building, in primary tumors of TNBCs may allow prediction of the site of future metastasis. Highrisk patients may benefit from increased surveillance of such sites.
Citation Format: Sergey Klimov, Andrew Green, Mohammed Aleskandarany, Emad Rakha, Ian Ellis, Michelle Reid, Rida C. G. Padmashree, Ritu Aneja. Multivariable Models for Predicting Likely Metastatic Sites for Triple Negative Breast Cancers. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B09.
Abstract B53: BRCA1 and BRCA2 mutations spectrum in Puerto Rican Hispanics
Authors: Pérez-Mayoral Julyann , Cora-Morges Adrian , Gonzalez-Rosa Krystel , Hernandez Jessica , Castillo Danielle , Herzog Josef , Weitzel Jeffrey , Cruz-Correa Marcia 
Published: March 2017

Abstract
Introduction: Hereditary breast cancer accounts for up to 10% of breast cancer cases. These hereditary breast cases have been shown to be associated with mutations in the BRCA1 and BRCA2 genes. The prevalence and types of mutations in these genes varies depending on the population and ethnicity under study. Identification of such specific mutations allows for site specific testing. In the absence of knowledge of specific mutation information, entire gene sequencing is necessary in order to identify the putative mutations involved in the predisposition to increased risk.
Objective: The objective of this project is to identify and annotate the mutations in BRCA1 and BRCA2 genes encountered in the Puerto Rican population which will allow for accessible genetic testing services to be offered.
Methods: From January 2014 to May 2016, we recruited 46 women that met the National Comprehensive Cancer Network guidelines for breast cancer genetic testing. Among recruited participants, 18 were diagnosed with breast cancer, 8 with ovarian cancer, 1 with both breast and ovarian cancer and 19 had family history of breast or ovarian cancer suggestive of hereditary cancer. The recruited individuals were submitted to genetic testing, first by the Hispanel breast cancer mutation panel, developed at City of Hope Division of Clinical Cancer Genetics. If negative on the Hispanel, Sanger sequencing was performed to evaluate the whole genes and confirm results.
Results: Our results showed 38 negative genetic testing for BRCA1/BRCA2, 4 variants of uncertain significance and 4 pathogenic mutations in the population under study. One pathogenic mutation was found in BRCA1 (BRCA1 exon15-16del) and 3 pathogenic mutations were found in BRCA2 (BRCA2 2022del5; BRCA2 4150G&gt;T (E1308X); BRCA2 6027del4).
Conclusion: The prevalence of mutations in this preliminary study is consistent with previous reports of BRCA mutations in Puerto Rico, which describe as BRCA2 as the most commonly mutated gene in the island. Additional studies are needed to fully elucidate the BRCA1/BRCA2 mutation spectrum in Puerto Rico for allowing the implementation of cost-effective and affordable genetic testing strategies for women in need.
Citation Format: Julyann Pérez-Mayoral, Adrian Cora-Morges, Krystel Gonzalez-Rosa, Jessica Hernandez, Danielle Castillo, Josef Herzog, Jeffrey Weitzel, Marcia Cruz-Correa. BRCA1 and BRCA2 mutations spectrum in Puerto Rican Hispanics. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B53.
Abstract B60: Inflammatory-based diagnostic markers of lung cancer in African Americans
Authors: Meaney Claire L. , Mitchell Khadijah A. , Zingone Adriana , Brown Derek , Tang Wei , Yu Yunkai , Cao Liang , Ryan Brid M. 
Published: March 2017

Abstract
Background:
African Americans have a higher risk of developing lung cancer compared with all other ethnic groups in the USA. Previous studies based on a small panel of markers suggested that certain circulating cytokines were associated with lung cancer. Given the complexity of the immune response in lung cancer and the multitude of cell types involved, we reasoned that examining a broad panel of inflammatory markers — including cytokines, chemokines, angiogenic and other pro-inflammatory factors — might identify a diagnostic signature of lung cancer for African American patients.
Methods:
Differences in 30 inflammatory marker serum levels, were measured in 308 African-American cases and 501 African American controls from the National Cancer Institute-Maryland (NCI-MD) case-control study using a Mesoscale multiplex platform (MSD). The panel of 30 serum inflammatory markers, included chemokines, cytokines and other inflammatory related proteins (Mesoscale VPLEX assay). Associations of the serum cytokine levels with lung cancer were analyzed using Stata statistical software (StataCorp, TX)
Results:
Fifteen inflammatory markers (CRP, IFN-gamma, IL-10, IL-15, IL-17A, IL-1beta, IL-6, IL-7, IL-8, IP-10, MCP-4, MIP-1alpha, TARC, TNF-alpha and VEGF) were significantly different among African American cases compared with African American controls. In agreement with our previous observations, levels of IL-10, IL-1beta, IL-6, IL-8, and TNF-alpha were associated with lung cancer risk. In addition, we found that CRP, IFN-gamma, IL-15, IL-7, IP-10, MCP-4, MIP-1alpha, TARC, and VEGF were associated with lung cancer in African Americans. The associations between CRP, IFN-gamma, IL-10, IL-15, IL-1beta, IL-6, IL-7, IL-8, IP-10 and MCP-4 levels and lung cancer among African Americans were significant after adjustment for additional potential confounding factors.
Conclusions:
Serum cytokine levels vary by race and might contribute to lung cancer differently between African Americans and European Americans. The findings presented here build upon recent work that identified associations between elevated levels of IL-10, IL-1beta, IL-6, IL-8, TNF-alpha and lung cancer among African Americans. Furthermore, by analyzing a broader spectrum of inflammation, we have identified additional markers of lung cancer for African American patients.
Citation Format: Claire L. Meaney, Khadijah A. Mitchell, Adriana Zingone, Derek Brown, Wei Tang, Yunkai Yu, Liang Cao, Brid M. Ryan. Inflammatory-based diagnostic markers of lung cancer in African Americans. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B60.
Abstract B74: DISPARITIES IN SURVIVAL AMONG HISPANIC CHILDREN WITH CANCER: THE TEXAS EXPERIENCE
Authors: Bertiery Erika Lopez , Xuan Lei , Pruitt Sandi 
Published: March 2017

Abstract
INTRODUCTION
In 2014, 15,780 incident cancers occurred among US children and adolescents, 15% of whom were Hispanic. Hispanic children with cancer have shown an increased mortality compared to Whites, however, existing studies are small and limited to a few cancer types. We evaluated the association of Hispanic ethnicity with mortality among children with all cancer types.
METHODS
Using Texas Cancer Registry data, we examined differences in all-cause mortality between Hispanics and Non-Hispanic Whites 0-19 years old diagnosed with a primary malignancy, 1995-2013. Differences in survival were estimated using unadjusted Kaplan-Meier curves and multivariable Cox proportional hazard models (adjusted for age, sex, year of diagnosis, cancer type, stage). Analyses were conducted for all cancer types and separately by type (leukemia, lymphoma, solid tumors).
RESULTS
Of 18,687 patients (8,659 Hispanic, 10,028 Non-Hispanic White), 27% had leukemia, 59% a solid tumor, and 13% had lymphoma. In unadjusted Kaplan-Meier analyses, Hispanics with leukemia (p&lt;.001) and solid tumors (p&lt;.001), but not lymphoma (p=.245) had higher mortality, compared to Whites. In adjusted Cox proportional hazard models, Hispanics had higher mortality for all cancer types combined (adjusted hazard ratio [aHR]: 1.30; 95% CI: 1.22-1.37), leukemia (aHR: 1.34; 95% CI: 1.19-1.51), and solid tumors (aHR: 1.26; 95% CI: 1.17-1.36), but not lymphoma (aHR: 1.13; 95% CI: 0.93-1.38).
CONCLUSION
Hispanic children with leukemia or solid tumors in Texas have higher risk of death, compared to Whites. Future research should seek to understand reasons underlying this disparity and to develop interventions designed to improve survival among Hispanic children with cancer.
Citation Format: Erika Lopez Bertiery, Lei Xuan, Sandi Pruitt. DISPARITIES IN SURVIVAL AMONG HISPANIC CHILDREN WITH CANCER: THE TEXAS EXPERIENCE. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B74.
Abstract C01: Understanding supportive care factors among African American breast cancer survivors
Authors: Davis Claudia M. 
Published: March 2017

Abstract
Introduction: Comprehensive breast cancer care includes not only diagnosis, staging and treatment for cancer, but also assessment and management of the physical, psychological, social, spiritual, and informational needs-collectively known as supportive care. This time frame, largely acknowledged until recently, is commonly referred to as the supportive phase. Several studies have documented the importance of addressing supportive care factors among breast cancer survivors. However, there appears to be a paucity of research concerning African American breast cancer survivors.
Purpose: The purpose of this study was to investigate and understand the patient-centered supportive care factors among community-dwelling African American breast cancer survivors.
Design/Methods: Via recruitment flyers, supportive groups and word of mouth, 169 women were recruited and screened from breast cancer support groups and community dwellers. One hundred and sixty women were eligible and 155 participated. The inclusion criteria were women who self-identified as African/Black American, age 25 years and older, diagnosed with breast cancer and at least 1 year post-active treatment. As part of a larger study, and using a qualitative descriptive approach, an open-ended questionnaire explored supportive care factors that were utilized by n = 155 African American breast cancer survivors in southern and northern California.
Results: The results revealed that the breast cancer survivors age at diagnosis ranged from 31-77 (M = 51.7), and years of survivorship ranged from 1-27 (M = 9.7). Among these women, the four (4) supportive care factors that were considered to be the most helpful and primary during their survivorship trajectory were their faith, supportive structures, being optimistic and having adequate access to information.
Conclusion: An understanding of these factors as reported by African American breast cancer survivors might facilitate discussion among members of the oncology care team and this shared dialogue could pave the way for a responsive healthcare model (e.g. survivorship care plans) and targeted intervention of psychosocial resources. The resultant effect could also inform and promote the delivery of culturally specific healthcare to address the supportive care needs among African American breast cancer survivors.
Citation Format: Claudia M. Davis. Understanding supportive care factors among African American breast cancer survivors. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr C01.
Abstract C06: Implementation of Universal Colorectal Cancer Screening for Lynch Syndrome: A Population-Based Study
Authors: Sierra Isabel , Diaz-Algorri Yaritza , Maldonado Valerie , Alicea Kimberly , Rosado Kathia , Cruz-Correa Marcia 
Published: March 2017

Abstract
Introduction: Colorectal cancer (CRC) is the leading cause of cancer death in Puerto Rico and the third one among US Hispanics. Up to 2-4% of colorectal cancer cases are caused by germline mutation in at least one of these four DNA mismatch repair (MMR) genes: MLH1, MSH2, MSH6, and PMS2. Mutations in these genes cause Lynch Syndrome (LS), the most common hereditary form of CRC. Immunohistochemistry (IHC) tests for the presence of MMR proteins and microsatellite instability (MSI) analysis is often performed on the tumor of CRC cases to screen for LS and as markers for prognosis. Universal screening of CRC for LS has been recommended by the National Comprehensive Cancer Network (NCCN) since 2014.
Objective: The purpose of this study was to determine the prevalence of positive LS-screening test as determined by absence of MMR proteins in CRC since the implementation of universal tumor screening for LS in the largest private pathology laboratory in Puerto Rico.
Methods: We collected the data from all CRC cases performed at Hato Rey Pathology Laboratories from September 2014 to December 2015. Pathologies performed where collected from 11 hospitals that cover the island of Puerto Rico. The data collected included results of IHC and MSI analysis as well as tumor location, gender, age, date reported and hospital.
Results: A total of 317 CRC tumors were evaluated for LS-screening; with a mean age of 66 years, and 54.3% were males. IHC analysis was performed in 288 cases and of these, 11.1% demonstrated absence of one or more of the MMR proteins, compatible with a positive screening test for LS. There were 21 cases that had only MSI analysis performed and they were all reported as microsatellite stable.
Conclusion: This is the first evaluation of a systematic program for Universal CRC screening for LS in Puerto Rico. Our data is consistent with results from other studies of US-Hispanics where approximately 10% of individuals of Hispanic origin with CRC have MSI. The observed prevalence of absence of MMR-proteins in our study supports universal screening of LS among Hispanics in accordance with NCCN guidelines.
Citation Format: Isabel Sierra, Yaritza Diaz-Algorri, Valerie Maldonado, Kimberly Alicea, Kathia Rosado, Marcia Cruz-Correa. Implementation of Universal Colorectal Cancer Screening for Lynch Syndrome: A Population-Based Study. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr C06.
Abstract C17: Unequal Financial Burdens Highlight Racial Disparities of Colon Cancer Patients in New York
Authors: Oveson Brian C. , Parikh Purvi , Telem Dana , Williams Jennifer , Bergamaschi Roberto , Sasson Aaron , Talamini Mark , Kim Joseph 
Published: March 2017

Abstract
Background: We have previously investigated racial disparities in colorectal cancer outcomes and discovered outcomes differences according to racial group. In our ongoing studies we sought to determine whether these disparities in survival resulted in unequal financial burdens between black and white patients. The purpose of this study was to identify whether financial disparities exist between the black and Caucasian colorectal cancer patients within New York State, with the ultimate goal of eliminating any differences.
Research Design: The Statewide Planning and Research Cooperative System (SPARCS) database of New York State (NYS) was used to compare costs of colon cancer surgery hospitalizations of the black and Caucasian patient populations between 2009-2013. Student t-tests were performed for comparison of inpatient hospital discharge, ambulatory surgery, and emergency department admission within the SPARCS database. Facility costs were calculated using hospital discharge data and Institutional Cost Reports. Logistic regression analysis examined race as the dependent variable to identify the etiology of cost disparity.
Results: Overall, 26,477 patients (white, n= 21,606; and black, n=4,871) underwent colon cancer treatment. Treatment costs in the black population were higher compared to the white population (mean, $64,747 vs $58,127; median, $44,951 vs $41, 285) (p&lt;0.001). Emergent operations were more frequent in the black population (52% vs 37%)(p&lt;0.001), as well as the median length of stay in the hospital (7 days vs 6 days) (p&lt;0.001). After these data were normalized with respect to length of stay and percentage of emergent operations, the costs for blacks were lower than the costs for Caucasians.
Conclusion: This study revealed that the black colon cancer population had higher costs than the Caucasian colon cancer population. We identified emergent operations and longer hospitalization as the primary etiologies for this disparity. Sufficient colon cancer screening for the black population might reduce the number of emergent operations and reduce length of hospitalization if the cancer is detected at an earlier stage.
Note: This abstract was not presented at the conference.
Citation Format: Brian C. Oveson, Purvi Parikh, Dana Telem, Jennifer Williams, Roberto Bergamaschi, Aaron Sasson, Mark Talamini, Joseph Kim. Unequal Financial Burdens Highlight Racial Disparities of Colon Cancer Patients in New York. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr C17.
Abstract C60: [Advocate Abstract:] Cancer Screening Guidelines and the Impact of the Minority Community
Authors: Aldrich Dawn 
Published: March 2017

Abstract
As of today, minority women are still leading the death toll in breast cancer. In addition, the under-served are confused with what we have worked so hard to promote in educating them about cancer screening, Some women were dismissive as they would tell us they don't have to get screened- not because they were not 40 or over but because they saw it on television. Interestingly, they were those who were concerned as they knew of people who were much younger or had no family history that were diagnosed or died of cancer. There is a concern of the minority and under-served community who are on the losing side of mist cancers, the questions are now coming in fast and furious and communication is extremely important. The poster will address the concerns, the statistics on diagnosis, stage and mortality rates.
Citation Format: Dawn Aldrich. [Advocate Abstract:] Cancer Screening Guidelines and the Impact of the Minority Community. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr C60.