bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the effects of HIV self‐testing compared to standard HIV testing services: a systematic review and meta‐analysis
Authors: Johnson Cheryl C , Kennedy Caitlin , Fonner Virginia , Siegfried Nandi , Figueroa Carmen , Dalal Shona , Sands Anita , Baggaley Rachel 
Published: May 2017

AbstractIntroduction: HIV self‐testing (HIVST) is a discreet and convenient way to reach people with HIV who do not know their status, including many who may not otherwise test. To inform World Health Organization (WHO) guidance, we assessed the effect of HIVST on uptake and frequency of testing, as well as identification of HIV‐positive persons, linkage to care, social harm, and risk behaviour.Methods: We systematically searched for studies comparing HIVST to standard HIV testing until 1 June 2016. Meta‐analyses of studies reporting comparable outcomes were conducted using a random‐effects model for relative risks (RR) and 95% confidence intervals. The quality of evidence was evaluated using GRADE.Results: After screening 638 citations, we identified five randomized controlled trials (RCTs) comparing HIVST to standard HIV testing services among 4,145 total participants from four countries. All offered free oral‐fluid rapid tests for HIVST and were among men. Meta‐analysis of three RCTs showed HIVST doubled uptake of testing among men (RR = 2.12; 95% CI: 1.51, 2.98). Meta‐analysis of two RCTs among men who have sex with men showed frequency of testing nearly doubled (Rate ratio = 1.88; 95% CI: 1.17; 3.01), resulting in two more tests in a 12–15‐month period (Mean difference = 2.13; 95% CI: 1.59, 2.66). Meta‐analysis of two RCTs showed HIVST also doubled the likelihood of an HIV‐positive diagnosis (RR = 2.02; 95% CI: 0.37, 10.76, 5.32). Across all RCTs, there was no indication of harm attributable to HIVST and potential increases in risk‐taking behaviour appeared to be minimal.Conclusions: HIVST is associated with increased uptake and frequency of testing in RCTs. Such increases, particularly among those at risk who may not otherwise test, will likely identify more HIV‐positive individuals as compared to standard testing services alone. However, further research on how to support linkage to confirmatory testing, prevention, treatment and care services is needed. WHO now recommends HIVST as an additional HIV testing approach.
HIV healthcare transition outcomes among youth in North America and Europe: a review
Authors: Tepper Vicki , Zaner Stefanie , Ryscavage Patrick 
Published: May 2017

AbstractIntroduction: The transition from paediatric to adult care poses risks to the health of young adults living with HIV if unsuccessful, including interruptions in care and poor health outcomes. Evolving best practices in HIV healthcare transition should ideally be informed by real‐world qualitative and quantitative clinical healthcare transition outcomes. There has been a recent proliferation of HIV healthcare transition outcome research, largely from Europe and North America.Methods: A literature search was undertaken using the online databases PubMed, Web of Science, and Google Scholar. Medical subject and text word searches were combined for terms relating to HIV, paediatric transition outcomes, and internal and external factors were used to identify peer‐reviewed articles.Results: In this paper, we review data on HIV healthcare transition outcomes in North America and Europe. Internal and external factors which may impact the success of HIV healthcare transition are examined. We describe ongoing research efforts to capture transition outcomes in the North America and Europe. Clinical, operational, and implementation science research gaps that exist to date are highlighted. Efforts to improve HIV healthcare transition research through country‐level surveillance networks and large multicentre cohorts, including data integration and linkage between paediatric and adult cohorts are discussed.Conclusions: We identified the need for a comprehensive approach to implementing empirically supported protocols to support healthcare transition for ALHIV. While there is limited prospective longitudinal cohort data available at this time, cohorts linking the paediatric and adolescent with ongoing surveillance into adulthood are being developed. Through a review of existing qualitative and quantitative healthcare transition outcomes studies, we identify emerging areas of consensus surrounding healthcare transition research implementation. Successful healthcare transition programmes in Europe and North America often share several characteristics, including implementation of a youth friendly multidisciplinary approach, consistent communication and integration between paediatric and adult care teams, and an individualized approach which is attuned the adolescent's transition readiness. Moving forward, the voices of youth and young adults living with HIV should be included in the development and evaluation of healthcare transition protocols to ensure that the definition of successful transition reflects all of the stakeholders in the transition process.
Living and dying to be counted: What we know about the epidemiology of the global adolescent HIV epidemic
Authors: Slogrove Amy L. , Mahy Mary , Armstrong Alice , Davies Mary‐Ann 
Published: May 2017

AbstractIntroduction: With increasing survival of vertically HIV‐infected children and ongoing new horizontal HIV infections, the population of adolescents (age 10–19 years) living with HIV is increasing. This review aims to describe the epidemiology of the adolescent HIV epidemic and the ability of national monitoring systems to measure outcomes in HIV‐infected adolescents through the adolescent transition to adulthood.Methods: Differences in global trends between younger (age 10–14 years) and older (age 15–19 years) adolescents in key epidemic indicators are interrogated using 2016 UNAIDS estimates. National population‐based survey data in the 15 highest adolescent HIV burden countries are evaluated and examples of national case‐based surveillance systems described. Finally, we consider the potential impact of adolescent‐specific recommendations in the 2016 WHO Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection.Discussion: UNAIDS estimates indicate the population of adolescents living with HIV is increasing, new HIV infections in older adolescents are declining, and while AIDS‐related deaths are beginning to decline in younger adolescents, they are still increasing in older adolescents. National population‐based surveys provide valuable estimates of HIV prevalence in older adolescents and recent surveys include data on younger adolescents. Only a few countries have nationwide electronic case‐based HIV surveillance, with the ability to provide population‐level data on key HIV outcomes in the diagnosed population living with HIV. However, in the 15 highest adolescent HIV burden countries, there are no systems tracking adolescent transition to adulthood or healthcare transition. The strength of the 2016 WHO adolescent‐specific recommendations on antiretroviral therapy and provision of HIV services to adolescents was hampered by the lack of evidence specific to this age group.Conclusions: Progress is being made in national surveillance and global monitoring systems to specifically identify trends in adolescents living with HIV. However, HIV programmes responsive to the evolving HIV prevention and treatment needs of adolescents can be facilitated further by: data disaggregation to younger and older adolescents and mode of HIV infection where feasible; implementation of tools to achieve expanded national case‐based surveillance; streamlining consent/assent procedures in younger adolescents and consensus on indicators of adolescent healthcare transition and transition to adulthood.
In-Shoe Plantar Pressure Profiles in Amateur Basketball Players
Authors: Kong Pui W. , Lam Wing K. , Ng Wei X. , Aziz Luqman , Leong Hin F. 
Published: May 2017

Background:
Biomechanical analysis of foot loading characteristics may provide insights into the injury mechanisms and guide orthotic prescription for basketball players. This study aimed to quantify in-shoe plantar pressure profiles in amateur players when executing typical basketball movements.

Methods:
Twenty male university basketball players performed four basketball-specific movement tasks—running, maximal forward sprinting, maximal 45° cutting, and layup—in a pair of standardized basketball shoes fitted with an in-shoe plantar pressure measurement system. Peak pressure (PP) and pressure-time integral (PTI) data were extracted from ten plantar regions. One-way repeated-measures analysis of variance was performed across the tasks, with significance set at P &lt; .05.

Results:
Distinct plantar pressure distribution patterns were observed among the four movements. Compared with running, significantly higher (P &lt; .05) PP and PTI of up to approximately 55% were found in sprinting and layup, particularly at the forefoot region. Similarly, significantly higher (P &lt; .05) PPs and PTIs, ranging from approximately 23% to 90%, were observed in 45° cutting compared with running at most foot regions.

Conclusions:
Compared with running, sprinting and layup demonstrated higher plantar loading in the forefoot region, and 45° cutting yielded increased plantar loading in most regions of the foot. Understanding the plantar pressure characteristics of different movements may be useful in optimizing footwear designs, orthosis use, or training strategies to minimize regional plantar loading during amateur basketball play.
Opening Up Communication: Assessing Open Access Practices in the Communication Studies Discipline
Authors: Schultz Teresa Auch 
Published: May 2017

INTRODUCTION Open access (OA) citation effect studies have looked at a number of disciplines but not yet the field of communication studies. This study researched how communication studies fare with the open access citation effect, as well as whether researchers follow their journal deposit policies. METHOD The study tracked 920 articles published in 2011 and 2012 from 10 journals and then searched for citations and an OA version using the program Publish or Perish. Deposit policies of each of the journals were gathered from SHERPA/RoMEO and used to evaluate OA versions. RESULTS From the sample, 42 percent had OA versions available. Of those OA articles, 363 appeared to violate publisher deposit policies by depositing the version of record, but the study failed to identify post-print versions for 87 percent of the total sample for the journals that allowed it. All articles with an OA version had a median of 17 citations, compared to only nine citations for non-OA articles. DISCUSSION &amp; CONCLUSION The citation averages, which are statistically significant, show a positive correlation between OA and the number of citations. The study also shows communication studies researchers are taking part in open access but perhaps without the full understanding of their publisher’s policies.
Preservation media, durations and cell concentrations of short-term storage affect key features of human adipose-derived mesenchymal stem cells for therapeutic application
Authors: Zhang Fengli , Ren Huaijuan , Shao Xiaohu , Zhuang Chao , Chen Yantian , Qi Nianmin 
Published: May 2017

BackgroundAdipose-derived mesenchymal stem cells (ADSCs) have shown great potential in the treatment of various diseases. However, the optimum short-term storage condition of ADSCs in 2∼8 °C is rarely reported. This study aimed at optimizing a short-term storage condition to ensure the viability and function of ADSCs before transplantation.MethodsPreservation media and durations of storage were evaluated by cell viability, apoptosis, adhesion ability and colony-forming unit (CFU) capacity of ADSCs. The abilities of cell proliferation and differentiation were used to optimize cell concentrations. Optimized preservation condition was evaluated by cell surface markers, cell cycle and immunosuppressive capacity.ResultsA total of 5% human serum albumin in multiple electrolytes (ME + HSA) was the optimized medium with high cell viability, low cluster rate, good adhesion ability and high CFU capacity of ADSCs. Duration of storage should be limited to 24 h to ensure the quality of ADSCs before transplantation. A concentration of 5 × 106cells/ml was the most suitable cell concentration with low late stage apoptosis, rapid proliferation and good osteogenic and adipogenic differentiation ability. This selected condition did not change surface markers, cell cycle, indoleamine 2, 3-dioxygenase 1 (IDO1) gene expression and kynurenine (Kyn) concentration significantly.DiscussionIn this study, ME + HSA was found to be the best medium, most likely due to the supplement of HSA which could protect cells, the physiological pH (7.4) of ME and sodium gluconate ingredient in ME which could provide energy for cells. Duration should be limited to 24 h because of reduced nutrient supply and increased waste and lactic acid accumulation during prolonged storage. To keep cell proliferation and limit lactic acid accumulation, the proper cell concentration is 5× 106cells/ml. Surface markers, cell cycle and immunosuppressive capacity did not change significantly after storage using the optimized condition, which confirmed our results that this optimized short-term storage condition of MSCs has a great potential for the application of cell therapy.
Dietary flavonoids of Spanish youth: intakes, sources, and association with the Mediterranean diet
Authors: Bawaked Rowaedh Ahmed , Schröder Helmut , Barba Lourdes Ribas , Cárdenas Gabriela , Peña-Quintana Luis , Rodrigo Carmen Pérez , Fíto Montserrat , Majem Lluis Serra 
Published: May 2017

BackgroundPlant-based diets have been linked to high diet quality and reduced risk of cardiovascular diseases. The health impact of plant-based diets might be partially explained by the concomitant intake of flavonoids. Estimation of flavonoids intake in adults has been important for the development of dietary recommendations and interventions for the prevention of weight gain and its consequences. However, estimation of flavonoids intake in children and adolescents is limited.MethodsAverage daily intake and sources of flavonoids were estimated for a representative national sample of 3,534 children and young people in Spain, aged 2–24 years. The data was collected between 1998 and 2000 by 24-h recalls. The Phenol-Explorer database and the USDA database on flavonoids content were used. Adherence to the Mediterranean diet was measured by the KIDMED index.ResultsThe mean and median intakes of total flavonoids were 70.7 and 48.1 mg/day, respectively. The most abundant flavonoid class was flavan-3-ols (35.7%), with fruit being the top food source of flavonoids intake (42.8%). Total flavonoids intake was positively associated with the KIDMED index (p < 0.001).ConclusionThe results of this study provide primary information about flavonoids intake and main food sources in Spanish children, adolescents and young adults. Participants with high daily mean intake of flavonoids have higher adherence to the Mediterranean diet.
The limits to global‐warming mitigation by terrestrial carbon removal
Authors: Boysen Lena R. , Lucht Wolfgang , Gerten Dieter , Heck Vera , Lenton Timothy M. , Schellnhuber Hans Joachim 
Published: May 2017

AbstractMassive near‐term greenhouse gas emissions reduction is a precondition for staying “well below 2°C” global warming as envisaged by the Paris Agreement. Furthermore, extensive terrestrial carbon dioxide removal (tCDR) through managed biomass growth and subsequent carbon capture and storage is required to avoid temperature “overshoot” in most pertinent scenarios. Here, we address two major issues: First, we calculate the extent of tCDR required to “repair” delayed or insufficient emissions reduction policies unable to prevent global mean temperature rise of 2.5°C or even 4.5°C above pre‐industrial level. Our results show that those tCDR measures are unable to counteract “business‐as‐usual” emissions without eliminating virtually all natural ecosystems. Even if considerable (Representative Concentration Pathway 4.5 [RCP4.5]) emissions reductions are assumed, tCDR with 50% storage efficiency requires >1.1 Gha of the most productive agricultural areas or the elimination of >50% of natural forests. In addition, >100 MtN/yr fertilizers would be needed to remove the roughly 320 GtC foreseen in these scenarios. Such interventions would severely compromise food production and/or biosphere functioning. Second, we reanalyze the requirements for achieving the 160–190 GtC tCDR that would complement strong mitigation action (RCP2.6) in order to avoid 2°C overshoot anytime. We find that a combination of high irrigation water input and/or more efficient conversion to stored carbon is necessary. In the face of severe trade‐offs with society and the biosphere, we conclude that large‐scale tCDR is not a viable alternative to aggressive emissions reduction. However, we argue that tCDR might serve as a valuable “supporting actor” for strong mitigation if sustainable schemes are established immediately.
Multi‐model and multi‐scenario assessments of Asian water futures: The Water Futures and Solutions (WFaS) initiative
Authors: Satoh Yusuke , Kahil Taher , Byers Edward , Burek Peter , Fischer Günther , Tramberend Sylvia , Greve Peter , Flörke Martina , Eisner Stephanie , Hanasaki Naota , Magnuszewski Piotr , Nava Luzma Fabiola , Cosgrove William , Langan Simon , Wada Yoshihide 
Published: May 2017

AbstractThis paper presents one of the first quantitative scenario assessments for future water supply and demand in Asia to 2050. The assessment, developed by the Water Futures and Solutions (WFaS) initiative, uses the latest set of global climate change and socioeconomic scenarios and state‐of‐the‐art global hydrological models. In Asia, water demand for irrigation, industry, and households is projected to increase substantially in the coming decades (30–40% by 2050 compared to 2010). These changes are expected to exacerbate water stress, especially in the current hotspots such as north India and Pakistan, and north China. By 2050, 20% of the land area in the Asia‐Pacific region, with a population of 1.6–2 billion, is projected to experience severe water stress. We find that socioeconomic changes are the main drivers of worsening water scarcity in Asia, with climate change impacts further increasing the challenge into the 21st century. Moreover, a detailed basin‐level analysis of the hydro‐economic conditions of 40 Asian basins shows that although the coping capacity of all basins is expected to improve due to gross domestic product (GDP) growth, some basins continuously face severe water challenges. These basins will potentially be home to up to 1.6 billion people by mid‐21st century.
Understanding the weather signal in national crop‐yield variability
Authors: Frieler Katja , Schauberger Bernhard , Arneth Almut , Balkovič Juraj , Chryssanthacopoulos James , Deryng Delphine , Elliott Joshua , Folberth Christian , Khabarov Nikolay , Müller Christoph , Olin Stefan , Pugh Thomas A. M. , Schaphoff Sibyll , Schewe Jacob , Schmid Erwin , Warszawski Lila , Levermann Anders 
Published: May 2017

AbstractYear‐to‐year variations in crop yields can have major impacts on the livelihoods of subsistence farmers and may trigger significant global price fluctuations, with severe consequences for people in developing countries. Fluctuations can be induced by weather conditions, management decisions, weeds, diseases, and pests. Although an explicit quantification and deeper understanding of weather‐induced crop‐yield variability is essential for adaptation strategies, so far it has only been addressed by empirical models. Here, we provide conservative estimates of the fraction of reported national yield variabilities that can be attributed to weather by state‐of‐the‐art, process‐based crop model simulations. We find that observed weather variations can explain more than 50% of the variability in wheat yields in Australia, Canada, Spain, Hungary, and Romania. For maize, weather sensitivities exceed 50% in seven countries, including the United States. The explained variance exceeds 50% for rice in Japan and South Korea and for soy in Argentina. Avoiding water stress by simulating yields assuming full irrigation shows that water limitation is a major driver of the observed variations in most of these countries. Identifying the mechanisms leading to crop‐yield fluctuations is not only fundamental for dampening fluctuations, but is also important in the context of the debate on the attribution of loss and damage to climate change. Since process‐based crop models not only account for weather influences on crop yields, but also provide options to represent human‐management measures, they could become essential tools for differentiating these drivers, and for exploring options to reduce future yield fluctuations.
The effects of spacecraft charging and outgassing on the LADEE ion measurements
Authors: Xie Lianghai , Zhang Xiaoping , Zheng Yongchun , Guo Dawei 
Published: May 2017

AbstractAbnormal ion signals can be usually seen in the Lunar Atmosphere and Dust Environment Explorer (LADEE) mission, including a suddenly enhanced current observed by the Lunar Dust Experiment (LDEX) near the sunlight‐shadow boundary and an unexpected water ion measured by the neutral mass spectrometer (NMS), with their magnitudes insensitive to the convection electric field of solar wind but dependent on the SW density and the elapsed time of LADEE mission. By analyzing both the LDEX measurements and the NMS measurements, we find that the current enhancement can be caused by a negatively charged spacecraft in the shadow region while the significant water ions should be some artificial ions from spacecraft outgassing. The artificial water ions show a peak near 8:00 LT that may be related to a sunlight‐controlled surface outgassing. In addition, the H2O flux can be enhanced near the end of the mission when the spacecraft has a lower altitude. It is found that the H2O enhancement is actually caused by an exosphere‐contributed return flux, rather than a real water exosphere.
Auroral precipitating energy during long magnetic storms
Authors: Cardoso F. R. , Alves M. V. , Parks G. K. , Fillingim M. O. , Simões Junior F. J. R. , Costa Junior E. , Koga D. 
Published: May 2017

AbstractThe power energy input carried by precipitating electrons into the auroral zone is an important parameter for understanding the solar wind‐magnetosphere energy transfer processes and magnetic storms triggering. Some magnetic storms present a peculiar long recovery phase, lasting for many days or even weeks, which can be associated with the intense and long‐duration auroral activity named HILDCAA (High Intensity Long Duration Continuous AE Activity). The auroral energy input during HILDCAAs has been pointed out as an essential key issue, although there have been very few quantitative studies on this topic. In the present work, we have estimated the auroral electron precipitating energy during the events of long (LRP) and short (SRP) storm recovery phase. The energy has been calculated from the images produced by the Ultraviolet Imager (UVI) on board the Polar satellite. In order to obtain accurate energy values, we developed a dayglow estimate method to remove solar contamination from the UVI images, before calculating the energy. We compared the UVI estimate to the Hemispheric Power (HP), to the empirical power obtained from the AE index, and to the solar wind input power. Our results showed that the UVI electron precipitating power for the LRP events presented a quasiperiodic fluctuation, which has been confirmed by the other estimates. We found that the LRP events are a consequence of a directly driven system, where there is no long‐term energy storage in the magnetosphere, and the auroral electrojets during these events are directly affected by the electron precipitating power.