bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Patient- and Parent-Reported Outcomes for Children with Congenital Hand Differences: A Systematic Review
Authors: Bickham Rebecca S. , Waljee Jennifer F. , Chung Kevin C. , Adkinson Joshua M. 
Published: May 2017

Background:
Patient- and parent-reported outcomes are increasingly considered as measures of treatment effectiveness for congenital conditions. The authors’ specific aim was to review the use of patient- and parent-reported outcomes of quality of life, activities of daily living, perception of hand appearance, and satisfaction after reconstruction for congenital hand differences.

Methods:
The authors reviewed articles addressing congenital hand differences from PubMed, MEDLINE, and EMBASE published between January of 1966 and October of 2016. The authors excluded studies that did not include reconstruction or lacked patient- or parent-reported outcomes. Investigators reviewed 48 studies and extracted the following: study type, level of evidence, type of congenital hand differences, sample size, procedure performed, length of follow-up, and domains and results of patient-satisfaction questionnaires.

Results:
Multiple studies across several types of congenital hand differences showed that a majority of patients and parents report improvements and are satisfied with postoperative outcomes. However, there were several patient cohorts (e.g., thumb duplication, thumb hypoplasia, radial longitudinal deficiency) who expressed dissatisfaction with outcomes and continue to experience decreased health-related quality of life.

Conclusions:
Overall, patient satisfaction and reports of health-related quality of life among children with congenital hand differences are favorable. Patients seem to cope and adapt well, but teasing and social relationships remain problematic, particularly as children enter school. This article highlights addressing these concerns before embarking on reconstruction.
Is Rotation a Concern with Anatomical Breast Implants? A Statistical Analysis of Factors Predisposing to Rotation
Authors: Montemurro Paolo , Papas Athanasios , Hedén Per 
Published: May 2017

Background:
Since their introduction in 1993, anatomical implants have provided a more natural appearance in breast augmentation, and many surgeons advocate their use and promote the good aesthetic results. However, the risk of implant rotation makes some of them reluctant to use these devices. The rotation rate varies among authors.

Methods:
The authors present a 6.5-year series of 531 patients who underwent primary breast augmentation with macrotextured anatomical implants in a Swedish facility performed by one consultant surgeon (P.M.). The authors examined the rotation rate and the correlation with possible predisposing factors such as preoperative breast cup size, childbirth, and body mass index.

Results:
A total of 20 implants (1.88 percent; 95 percent CI, 1.15 to 2.89 percent) in 19 patients (3.58 percent; 95 percent CI, 2.17 to 5.53 percent) were rotated. In one patient (0.22 percent), both implants rotated, whereas in the remaining patients, the rotation was unilateral. The authors were unable to establish a statistically significant correlation between implant rotation and previous childbirth or increased body mass index. However, there was a relation between rotation rate and preoperative breast cup size that showed an upward trend as the cup size increased from A to C.

Conclusion:
The authors believe that if the implant is correctly selected and the operation is performed meticulously with proper pocket dissection, the rotation rate is minimal and it should not be considered a disadvantage for the use of anatomical implants.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Risk, III.
A Review of 101 Consecutive Subcutaneous Mastectomies and Male Chest Contouring Using the Concentric Circular and Free Nipple Graft Techniques in Female-to-Male Transgender Patients
Authors: Knox Aaron D. C. , Ho Adelyn L. , Leung Leslie , Hynes Sally , Tashakkor A. Yashar , Park Yoon Soo , Macadam Sheina A. , Bowman Cameron C. 
Published: May 2017

Background:
Many techniques exist for subcutaneous mastectomy in female-to-male transgender patients. The authors review outcomes for two techniques and present an algorithm to aid surgeons in technique selection.

Methods:
One hundred one consecutive female-to-male transgender patients undergoing subcutaneous mastectomy using the concentric circular or free nipple graft technique were retrospectively reviewed. An algorithm for procedure selection was created using classification and regression tree analysis. Aesthetic results (nipple-areola complex, scar, and chest contour) were also independently reviewed.

Results:
Two hundred two subcutaneous mastectomies were performed (concentric circular, 92 breasts; free nipple graft, 110 breasts). The overall complication rate was 21.3 percent, with 6.4 percent requiring operative intervention (free nipple graft, 1 percent; concentric circular, 13 percent; p < 0.001). The overall revision rate was 23.8 percent (free nipple graft, 12.7 percent; concentric circular, 37.0 percent; p < 0.001). In the concentric circular group, there were 3.3 times the odds of total complications (p = 0.03) and 4.0 times the odds of revision surgery (p < 0.001). Mean aesthetic scores for the concentric circular technique were superior to free nipple graft for scar (3.39 versus 2.62; p < 0.001) and contour (3.82 versus 3.34; p < 0.001).

Conclusions:
In patients who meet selection criteria, the concentric circular technique is preferred because of fewer scars, improved aesthetic contour, and potential for retained nipple sensation. These patients must be counseled regarding the higher rate of complications and revisions. It was determined that smokers and those with a nipple-to–inframammary fold distance greater than 7 cm or nipple-to–inframammary fold distance less than 7 cm and a body mass index greater than 27 kg/m2 should undergo the free nipple graft technique because of the increased risk of complications with the concentric circular technique.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Learning fast and slow: deviations from the matching law can reflect an optimal strategy under uncertainty
Authors: Iigaya Kiyohito , Ahmadian Yashar , Sugrue Leo P. , Corrado Greg S. , Loewenstein Yonatan , Newsome William T. , Fusi Stefano 
Published: May 2017

AbstractBehavior which deviates from our normative expectations often appears irrational. A classic example concerns the question of how choice should be distributed among multiple alternatives. The so-called matching law predicts that the fraction of choices made to any option should match the fraction of total rewards earned from the option. This choice strategy can maximize reward in a stationary reward schedule. Empirically, however, behavior often deviates from this ideal. While such deviations have often been interpreted as reflecting ‘noisy’, suboptimal, decision-making, here we instead suggest that they reflect a strategy which is adaptive in nonstationary and uncertain environments. We analyze the results of a dynamic foraging task. Animals exhibited significant deviations from matching, and animals turned out to be able to collect more rewards when deviation was larger. We show that this behavior can be understood if one considers that animals had incomplete information about the environments dynamics. In particular, using computational models, we show that in such nonstationary environments, learning on both fast and slow timescales is beneficial. Learning on fast timescales means that an animal can react to sudden changes in the environment, though this inevitably introduces large fluctuations (variance) in value estimates. Concurrently, learning on slow timescales reduces the amplitude of these fluctuations at the price of introducing abiasthat causes systematic deviations. We confirm this prediction in data – monkeys indeed solved the bias-variance tradeoff by combining learning on both fast and slow timescales. Our work suggests that multi-timescale learning could be a biologically plausible mechanism for optimizing decisions under uncertainty.
High lumenal chloride in the lysosome is critical for lysosome function
Authors: Chakraborty Kasturi , Leung KaHo , Krishnan Yamuna 
Published: May 2017

AbstractLysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride reporter to measure lysosomal chloride inCaenorhabditis elegansas well as murine and human cell culture models of lysosomal diseases. We find that the lysosome is highly enriched in chloride, and that chloride reduction correlates directly with a loss in the degradative function of the lysosome. In nematodes and mammalian cell culture models of diverse lysosomal disorders, where previously only lysosomal pH dysregulation has been described, massive reduction of lumenal chloride is observed that is ~104-fold greater than the accompanying pH change. Reducing chloride within the lysosome impacts Ca2+release from the lysosome and impedes the activity of specific lysosomal enzymes indicating a broader role for chloride in lysosomal function. −149 words.
Anxiety modulates perception of facial fear in a pathway-specific, lateralized, manner
Authors: Im Hee Yeon , Adams Reginald B. , Boshyan Jasmine , Ward Noreen , Cushing Cody A. , Kveraga Kestutis 
Published: May 2017

AbstractFacial expression and eye gaze provide a shared signal about threats. While averted-gaze fear clearly points to the source of threat, direct-gaze fear renders the source of threat ambiguous. Dual processing routes have been proposed to mediate these processes: reflexive processing via magnocellular (M-) pathway and reflective processing via parvocellular (P-) pathway. We investigated how observers’ trait anxiety modulates Mand P-pathway processing of clear and ambiguous threat cues. We performed fMRI on a large cohort (N=108) widely ranging in trait anxiety while they viewed fearful or neutral faces with averted or directed gaze. We adjusted luminance and color of the stimuli to selectively engage M- or P-pathway processing. We found that higher anxietyfacilitatedprocessing of averted-gaze fear projected to M-pathway, butimpairedperception of direct-gaze fear projected to P-pathway. Increased right amygdala reactivity was associated with higher anxiety, only for averted-gaze fear presented to M-pathway. Conversely, increased left amygdala reactivity was associated with higher anxiety for P-biased, direct-gaze fear. This lateralization was more pronounced with higher anxiety. Our findings suggest that trait anxiety has differential effects on perception of clear and ambiguous facial threat cues via selective engagement of M and P pathways and lateralization of amygdala reactivity.
Phenotype prediction in anEscherichia colistrain panel
Authors: Galardin Marco , Koumoutsi Alexandra , Herrera-Dominguez Lucia , Varela Juan Antonio Cordero , Telzerow Anja , Wagih Omar , Wartel Morgane , Clermont Olivier , Denamur Erick , Typas Athanasios , Beltrao Pedro 
Published: May 2017

SummaryUnderstanding how genetic variation contributes to phenotypic differences is a fundamental question in biology. Here, we set to predict fitness defects of an individual using mechanistic models of the impact of genetic variants combined with prior knowledge of gene function. We assembled a diverse panel of 696Escherichia colistrains for which we obtained genomes and measured growth phenotypes in 214 conditions. We integrated variant effect predictors to derive gene-level probabilities of loss of function for every gene across strains. We combined these probabilities with information on conditional gene essentiality in the reference K-12 strain to predict the strains’ growth defects, providing significant predictions for up to 38% of tested conditions. The putative causal variants were validated in complementation assays highlighting commonly perturbed pathways in evolution for the emergence of growth phenotypes. Altogether, our work illustrates the power of integrating high-throughput gene function assays to predict the phenotypes of individuals.HighlightsAssembled a reference panel ofE. colistrainsGenotyped and high-throughput phenotyped theE. colireference strain panelReliably predicted the impact of genetic variants in up to 38% of tested conditionsHighlighted common genetic pathways for the emergence of deleterious phenotypes
Rare non-coding variants are associated with plasma lipid traits in a founder population
Authors: Igartua Catherine , Mozaffari Sahar V , Nicolae Dan L , Ober Carole 
Published: May 2017

AbstractFounder populations are ideally suited for studies on the clinical effects of alleles that are rare in general populations but occur at higher frequencies in these isolated populations. Whole genome sequencing in 98 South Dakota Hutterites, a founder population of European descent, and subsequent imputation to the Hutterite pedigree revealed 660,238 single nucleotide polymorphisms (SNPs; 98.9% non-coding) that are rare (<1%) or absent in European populations, but occur at frequencies greater than 1% in the Hutterites. We examined the effects of these rare in European variants on plasma levels of LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), total cholesterol and triglycerides (TG) in 828 Hutterites and applied a Bayesian hierarchical framework to prioritize potentially causal variants based on functional annotations. We identified two novel non-coding rare variants associated with LDL-C (rs17242388 inLDLR) and HDL-C (rs189679427 betweenGOT2andAPOOP5), and replicated previous associations of a splice variant inAPOC3(rs138326449) with TG and HDL-C. All three variants are at well-replicated loci in genome wide association study (GWAS) but are independent from and have larger effect sizes than the known common variation in these regions. We also identified variants at two novel loci (rs191020975 inEPHA6and chr1:224811120 inCNIH3) at suggestive levels of significance with LDL-C. Candidate expression quantitative loci (eQTL) analyses in lymphoblastoid cell lines (LCLs) in the Hutterites suggest that these rare non-coding variants are likely to mediate their effects on lipid traits by regulating gene expression. Overall, we provide insights into the mechanisms regulating lipid traits and potentially new therapeutic targets.
Relationships between golf range users’ participation motivation, satisfaction, and exercise adherence intention
Authors: Shim Kyoung-Ran , Paek Byung-Joo , Yi Ho-Taek , Huh Jong-Ho 
Published: May 2017

PurposeThis paper aims to identify the relationship between participation motivation, satisfaction and exercise adherence intention of golf range users on the basis of self-determination theory.Design/methodology/approachFor this purpose, the authors proposed research questions and a conceptual research model as well. Then, the authors surveyed users of golf ranges located in Seoul Metropolitan City and Gyeonggi-do province.FindingsBy applying convenience sampling, the authors received a total of 313 questionnaires. Results were as follows. First, among the participation motivation sub-factors, health-oriented motivation, achievement motivation, pleasure-oriented motivation and self-displayed motivation had a significant effect on emotional satisfaction, while achievement motivation and pleasure-orientation motivation had a significant effect on performance satisfaction. Second, the following participation motivation factors had a significant effect on exercise adherence intention: health-orientation motivation, achievement motivation and pleasure-orientation motivation. Third, among the satisfaction factors, emotional satisfaction and performance satisfaction both had a significant effect on exercise adherence intention.Originality/valueThis is one of the first papers to examine the relationships that exist between golf range users’ participation motivation, satisfaction and exercise adherence intention.
Cost-benefit analysis for regenerative energy storage in metro
Authors: Li Xiang , Gao Ziyou 
Published: May 2017

Purpose
Regenerative braking is an efficient energy saving technology in urban rail system, in which the recovery energy from braking trains is collected by some equipments and released to accelerating trains when needed. However, the high cost and low lifetime of storage devices prevent the widespread use of this technology. The purpose of this paper is to conduct thorough cost-benefit analysis to facilitate China’s urban rail companies to make decisions on the use of such technology.

Design/methodology/approach
To evaluate the benefit from regenerative energy storage, the authors formulate an improved integrated scheduling and speed control model to calculate the net energy consumption associated with different energy recovery rates and then define the benefit as the amount of energy saving arising from the usage of storage equipments. With the frequent charge/discharge operations on storage equipments, the energy recovery rate generally decreases which lowers the benefit, but the maintenance cost increases. By trading-off benefit and cost, the authors derive the optimal scrapping time, the maximum profit and the profitability condition for storage devices.

Findings
Simulation studies based on the Beijing Metro Yizhuang Line of China are given. The results show that compared with the current timetable and speed profile, the integrated scheduling and speed control approach with energy recovery rate of 0.5 can reduce the net energy consumption by 12.69 per cent; the net energy consumption can be well approximated as a linear function of energy recovery rate; and the maximum profit and the optimal scrapping time on regenerative energy storage devices are both positively related to the electricity price. The allowance proportion and the number of service trains such that busy lines with higher electricity price or allowance proportion have advantages to use the regenerative energy storage devices.

Research limitations/implications
In this work, a linear energy recovery rate and a linear maintenance cost are used in the cost-benefit analysis process. In future research, the more accurate expressions on energy recovery rate and maintenance cost should be considered if more data on recovery rate and maintenance cost can be gathered.

Originality/value
The main values of this paper are to develop the integrated optimization approaches for train scheduling and speed control and, on this basis, make thorough cost-benefit analysis for regenerative energy storage to improve the operations management of urban rail transit.
Critical management issues in China’s socio-economic transformation
Authors: Tachia Chin , Ren-huai Liu 
Published: May 2017

Purpose
This paper aims to introduce ten studies included in this themed issue that illustrate from multifaceted angles some critical management issues and context-specific challenges on strategy and innovation facing the State and enterprises during China’s socio-economic transition. Instead of focusing on topics from the literature, this special issue (SI) pays more attention to characterising unique Chinese business practices in the transformation period.

Design/methodology/approach
The ten manuscripts were selected for this SI so that readers can compare how scholars used different research designs and multiple analytical and statistical approaches to draw conclusions.

Findings
These studies involve a wide range of aspects, as well as diversified perspectives demonstrating some critical management issues and context-specific phenomenon associated with the development of strategy and innovation in contemporary China. The results show that while pollution-related issues have had a damaging effect on China’s business environment, the Chinese government has to enact and enforce stricter environmental laws to promote technology innovation in a healthier manner; moreover, Chinese firms should pay greater attention to the trade-off between the increasing of resource consumption for growth and the reducing of energy use for the sake of the planet. In response to the grand innovation challenges Chinese manufacturing is confronted with, these papers suggest that policy support may not always be beneficial but sometimes detrimental to independent innovation, and that Chinese manufacturers may ultimately get access to the key and core technology of forerunners by forming a R&D strategic alliance in periphery knowledge/technology first. Overall, the outcomes of these studies provide a bigger picture and intriguing implications that may inspire practitioners, policymakers and academics to further ponder relevant issues in a more comprehensive way.

Originality/value
All ten studies based on original data were not reported elsewhere and demonstrated results that have not been addressed in prior research. This paper enriches one’s understanding of how Chinese firms have been deliberately seeking their own distinctive trajectories of developing strategy and innovation dissimilar to those of advanced economy companies, given the peculiar cultural background and institutional systems. Future research trends and opportunities are also outlined.
How China’s manufacturers achieve technological catch-up
Authors: Li Weibao , Wu Weiwei , Liu Yexin , Yu Bo 
Published: May 2017

PurposeThe purpose of this paper is to explore how China’s manufacturers catch up with the forerunners through R&D cooperation by developing a new mode of latecomer–forerunner R&D cooperation, i.e. the periphery–core mode, which provides a viable way for China’s manufacturers to obtain forerunners’ core knowledge from their periphery knowledge via knowledge spillover and knowledge transfer.Design/methodology/approachThe paper first reviews the literature on R&D cooperation process in the catching-up context and knowledge management in R&D cooperation. Then, three cases of R&D cooperation between China’s advanced technology manufacturers and their forerunners are introduced, with emphasis on interactivities in R&D cooperation and knowledge spillover. On the basis of the multi-case study, the periphery–core mode of R&D cooperation between latecomers and forerunners is conducted.FindingsThe paper finds that the latecomers can catch up with their forerunners by acquiring forerunners’ core technology used in periphery R&D activities. Through formal and informal interactions, the forerunners’ core technology can be extracted and transferred to latecomers, which the latecomers can then absorb and further develop. Thus, it can be concluded that the periphery–core mode of R&D cooperation is a viable way for the latecomers to get access to forerunners’ core technology.Originality/valueThe paper contributes to the literature on the catching-up theory by developing the periphery–core mode as a new mode for the latecomers to catch up with the forerunners. It expands the understanding of the latecomer–forerunner R&D cooperation by focusing on the way that China’s manufacturers as latecomers catch up with the forerunners by accessing the forerunners’ core knowledge from their R&D cooperation in periphery knowledge. The paper shows the mechanism of knowledge transfer and spillover in R&D cooperation. The role of communications, especially informal communication between cooperation partners, is emphasized in this process. This study also provides a new perspective for cooperation partner selection by arguing that latecomers can choose their cooperation partners according to the periphery and core knowledge they possess, other than the relationship between them. Besides, this paper emphasizes the mutual support between knowledge transfer, knowledge spillover and knowledge absorption, which is necessary for latecomers to achieve successful catching up in periphery–core R&D cooperation.