bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed and incomplete treatment may result in dural fistula development in children with Vein of Galen malformation
Authors: Meila Dan , Schmidt Cynthia , Melber Katharina , Grieb Dominik , Jacobs Cornelius , Jacobs Collin , Lanfermann Heinrich , Brassel Friedhelm 
Published: November 2017

The association of dural arteriovenous fistulas (DAVF) in children with Vein of Galen malformation (VGM) has recently been reported for the first time. In a larger series of cases treated with transarterial NBCA embolization, 30% had DAVF. We wanted to analyze the development of DAVF in our cohort of children with VGM and to evaluate whether their occurrence depends on different treatment timing and embolic materials. We analyzed 43 VGM cases treated with a combined transarterial and transvenous approach between 2003 and 2016. In our early series until 2011, we used coils solely in 21 children. Since 2012, 22 children were treated with the combination of coils and Onyx. In the early series treated with coils solely, no case presented initially with or developed DAVF over time on follow-up angiograms. In our recent series we found four cases (9%) with DAVF. In two patients (5%), DAVF were found on the initial angiogram. Both patients presented at our department at age >2 years and were not treated elsewhere before. One patient (2%) presented at our department with too proximal occlusion of arterial feeders performed at another institution before. Only one patient (2%) developed DAVF in our department after the transarterial use of Onyx. Interestingly, this child did not develop DAVF as long as we used coils solely and his DAVF was localized exactly where an Onyx cast was identified. In conclusion, delayed and incomplete treatment may have a considerable impact on the occurrence of DAVF in VGM.
Structural integrity of rotator cuff at 16 years following repair: good long-term outcomes despite recurrent tears
Authors: Elliott Robert S. J. , Lim Yi-Jia , Coghlan Jennifer , Troupis John , Bell Simon 
Published: November 2017

Background There are few studies reporting long-term rotator cuff integrity following repair. The present study reports a case series of surgically repaired supraspinatus tendons followed up with clinical outcomes and ultrasound imaging after an average of 16 years. Methods The prospectively studied clinical outcomes at short-, medium- and long-term follow-up in 27 shoulders in 25 patients treated with arthroscopic subacromial decompression and mini-open rotator cuff repair have been reported previously. The functional outcomes scores recorded were the University of California Los Angeles (UCLA), American Shoulder and Elbow Surgeons (ASES) and Simple Shoulder Test (SST) measures. These patients then underwent an ultrasound scan with respect to the long-term assessment of the shoulder and the integrity of the repair. Results A recurrent tear was noted in 37% of patients at 16.25 years after surgery, of which 50% were small. Two patients required repeat surgery. Patients had a mean UCLA score of 30, an ASES score of 91.3 and a SST score of 9.5 with a 85% level of satisfaction with surgery. Patients with a recurrent tear had outcome scores equivalent to those with an intact cuff with no significant pain. No independent risk factors were identified as predictors for recurrent tear. Conclusions Patients showed sustained benefit and satisfaction at long-term follow-up despite a 37% recurrence of full-thickness supraspinatus tear.
Frontotemporal dementia: latest evidence and clinical implications
Authors: Young Juan Joseph , Lavakumar Mallika , Tampi Deena , Balachandran Silpa , Tampi Rajesh R. 
Published: November 2017

Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive syndromes that present with impairment of executive functioning, changes in behavior, and a decrease in language proficiency. FTD is the second most common form of dementia in those younger than 65 years and is expected to increase in prevalence as the population ages. This goal in our review is to describe advances in the understanding of neurobiological pathology, classification, assessment, and treatment of FTD syndromes. Methods: PubMed was searched to obtain reviews and studies that pertain to advancements in genetics, neurobiology, neuroimaging, classification, and treatment of FTD syndromes. Articles were chosen with a predilection to more recent preclinical/clinical trials and systematic reviews. Results: Recent reviews and trials indicate a significant advancement in the understanding of molecular and neurobiological clinical correlates to variants of FTD. Genetic and histopathologic markers have only recently been discovered in the past decade. Current therapeutic modalities are limited, with most studies reporting improvement in symptoms with nonpharmacological interventions. However, a small number of studies have reported improvement of behavioral symptoms with selective serotonin reuptake inhibitor (SSRI) treatment. Stimulants may help with disinhibition, apathy, and risk-taking behavior. Memantine and cholinesterase inhibitors have not demonstrated efficacy in ameliorating FTD symptoms. Antipsychotics have been used to treat agitation and psychosis, but safety concerns and side effect profiles limit utilization in the general FTD population. Nevertheless, recent breakthroughs in the understanding of FTD pathology have led to developments in pharmacological interventions that focus on producing treatments with autoimmune, genetic, and molecular targets. Conclusion: FTD is an underdiagnosed group of neurological syndromes comprising multiple variants with distinct neurobiological profiles and presentations. Recent advances suggest there is an array of potential novel therapeutic targets, although data concerning their effectiveness are still preliminary or preclinical. Further studies are required to develop pharmacological interventions, as there are currently no US Food and Drug administration approved treatments to manage FTD syndromes.
Rehabilitation for patients with rheumatic diseases: Patient experiences of a structured goal planning and tailored follow-up programme
Authors: Dager Turid Nygaard , Kjeken Ingvild , Berdal Gunnhild , Sand-Svartrud Anne-Lene , Bø Ingvild , Dingsør Anne , Eppeland Siv Grødal , Hagfors Jon , Hamnes Bente , Nielsen Merete , Slungaard Bente , Wigers Sigrid Hørven , Hauge Mona-Iren 
Published: November 2017

Objective: To explore the significance of the content of rehabilitation in terms of achieving a personal outcome, and to understand the significance of tailored follow-up interventions for individual efforts to prolong health behaviour change after rehabilitation. Design: Semi-structured interviews with patients who had received an extended rehabilitation programme. All interviews were transcribed verbatim. A thematic analysis was applied. Subjects: A purposeful sample of 18 patients with rheumatic diseases who had attended specialized multidisciplinary rehabilitation with an extended programme consisting of a self-help booklet, structured goal-setting talks and tailored follow-up calls based on motivational interviewing. Results: Four overarching and interrelated themes were identified. Experienced Person-centred interventions represented a basis for the patients’ motivation and personal outcomes. Confident self-management describes a new confident approach to exercise and illness management after rehabilitation with person-centred interventions. For many, this included reaching a different mindset, a change of illness perception. Continuity of the personal outcomes describes the importance of follow-up telephone calls to maintain the focus on goals and continued efforts. Building on established relationships and practising person-centred communication were essential. Conclusion: Tailoring of communication and rehabilitation interventions may be a premise for enhancing health behaviour, including a beneficial illness perception. Structured goal setting and follow-up telephone calls using motivational interviewing enhance motivation and may contribute to prolonged goal attainment.
Pancreatic function following post‐endoscopic retrograde cholangiopancreatography pancreatitis: A controlled cohort study with long‐term follow‐up
Authors: Leerhøy Bonna , Shabanzadeh Daniel M , Nordholm-Carstensen Andreas , Novovic Srdan , Hansen Mark B , Jørgensen Lars N 
Published: November 2017

BackgroundAcute pancreatitis is one of the most common causes of gastrointestinal‐related hospitalization and the incidence is increasing. Endo‐ and exocrine pancreatic function can be compromised after acute pancreatitis.ObjectiveThe purpose of this study was to explore the long‐term consequences of post‐endoscopic retrograde cholangiopancreatography pancreatitis (PEP) on pancreatic function.MethodsA follow‐up study was carried out with prospective assessment of endo‐ and exocrine pancreatic function among cases with previous PEP and matched controls from a Danish cohort consisting of 772 patients undergoing first‐time ERCP. Pancreatic function was evaluated by faecal‐elastase‐1 test, blood levels of haemoglobin A1c, C‐peptide, vitamin B12, vitamin D and indirectly by changes in body weight.ResultsTwenty‐nine cases and 49 controls participated in the study. Mean follow‐up time (standard deviation) was 58 (21) months. Twelve (41%), eight (28%) and nine (31%) patients had mild, moderate and severe PEP, respectively. There was no difference between cases and controls with regard to pancreatic function parameters and PEP severity was not associated with pancreatic function. Factors associated with pancreatic function impairment included body mass index, alcohol consumption, age and smoking.ConclusionThis study suggests that long‐term pancreatic function following PEP is similar to the pancreatic function of other patients with comparable gallstone‐related morbidity.
Brachytherapy in the adjuvant management of keloid scars: literature review
Authors: Goutos Ioannis , Ogawa Rei 
Published: November 2017

[Formula: see text] Introduction: Radiation therapy is a well-recognised modality for the adjuvant treatment of keloid scars. It can be conventionally delivered as external beam using a large apparatus at a distance from the lesion or as brachytherapy with specialised equipment to enable the delivery of treatment in the immediate vicinity of the keloidal tissue. Methods: An English literature review was performed with keywords ‘brachytherapy’ and ‘keloid’ using the databases PubMed, Embase and Web of Science from their individual dates of inception until June 2017. Studies pertinent to the field are presented in a chronological manner to depict the evolution of different brachytherapy strategies over the last decades. We also discuss considerations relating to the risk of secondary carcinogenesis, which are relevant to shared decision-making in the clinical setting. Discussion: Low dose rate interstitial brachytherapy was first introduced in the English literature in 1976 and currently appears to have been superseded by more modern approaches, including high dose rate interstitial brachytherapy. This modality compares favourably to more traditional modes of radiotherapy in terms of recurrence as well as rates of symptomatic relief from keloidal symptoms. Superficial brachytherapy was introduced more recently in the relevant literature and appears to be associated with favourable therapeutic outcomes compared to external beam radiation therapy. Conclusion: Brachytherapy is a valid modality of radiotherapy for the adjuvant treatment of keloid scars, with high dose rate interstitial and surface regimens gaining in popularity over recent years. Further research needs to focus on randomised controlled trials to further establish the role of different radiotherapy modalities in keloid scar management.
Investigation of efficacy of treatment in spinal cord injury: Erythropoietin versus methylprednisolone
Authors: Ozkunt Okan , Sariyilmaz Kerim , Gemalmaz Halil Can , Gürgen Seren Gülsen , Yener Ulaş , Dikici Fatih 
Published: November 2017

Background: Investigation of the expression of platelet-derived growth factor (PDGF)-β and glial fibrillary acidic protein (GFAP) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (EPO) and methylprednisolone (MP). Methods: Thirty adult female rats were randomly divided into three even groups. A laminectomy was applied to thoracic ninth vertebra and contusion injury was induced by extradural application of an aneurysm clip. Group 1 rats received one-time intrathecal administration of normal saline, group 2 rats received MP, and group 3 rats received EPO. Motor neurological function was evaluated by the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale. Thirty days after the surgery, T8–10 segments of the spinal cords were extracted and the immunohistochemical assay revealed the number of PDGF-β- and GFAP-positive cells. Results: Evaluation of the last control animal showed that BBB score in the EPO group showed an increase from 1 to 12 ( p < 0.05). The immunohistochemical assay revealed that the number of PDGF-β- and GFAP-positive cells was significantly higher in EPO group ( p = 0.000) when compared to MP and control groups. After studying the effect of PDGF-β expression on the locomotor function, we determined that PDGF-β expression and locomotor function after a spinal injury has a strong relationship ( p < 0.05). Conclusion: EPO seems to better increase the expression of PDGF-β, thus produce better results in locomotor functions when compared to MP.
Functional Outcomes After the Surgical Management of Isolated Anterolateral Leg Chronic Exertional Compartment Syndrome
Authors: Gatenby Grace , Haysom Samuel , Twaddle Bruce , Walsh Stewart 
Published: November 2017

Background: Failure rates of up to 20% have been reported after fasciotomy for chronic exertional compartment syndrome (CECS). There is some evidence that postoperative failure and complication rates are higher in the posterior compartments of the lower leg than the anterolateral compartments. Isolated compartment surgery may put patients at risk of requiring revision surgery because of the risk of developing posterior compartment disease. Hypothesis: Isolated anterolateral fasciotomy for CECS, in the absence of posterior compartment symptoms, produces satisfactory functional outcomes. Study Design: Case series; Level of evidence, 4. Methods: Between 2006 and 2012, patients who had positive intracompartment pressure-testing findings and who underwent isolated anterolateral fasciotomy release for CECS were given a self-administered questionnaire. The minimum follow-up was 3 years. The questionnaire addressed time to return to sport and ongoing symptoms. A visual analog scale was used to assess pain during exercise before and after surgery (score: 0, no pain; 10, worst pain imaginable); overall satisfaction with the procedure was assessed as well. Of 31 eligible patients, 20 patients (36 legs operated on) were assessed. Results: Postoperatively, 90% of participants returned to the same or higher level of sport. The mean pain score during exercise before surgery was 8.17, whereas it was 1.74 after surgery. The overall mean patient satisfaction score was 8.64. Only 1 leg (2.8%) went on to develop posterior compartment syndrome. Conclusion: Isolated anterolateral fasciotomy for CECS produced excellent functional outcomes. Our rate of recurrence was low compared with those found in the literature, and 90% of participants returned to their same or higher level of sport postoperatively.
Excluded from school: Autistic students’ experiences of school exclusion and subsequent re-integration into school
Authors: Brede Janina , Remington Anna , Kenny Lorcan , Warren Katy , Pellicano Elizabeth 
Published: November 2017

Background and aims All children have the right to receive an education and to be included in school. Yet young people on the autism spectrum, who are already vulnerable to poor health and social outcomes, are at increased risk of school exclusion. The current study sought to understand the key factors surrounding the school exclusion experiences of a group of autistic students with particularly complex needs, and their subsequent re-integration into education. Method We interviewed nine intellectually able students (eight male, one female; M age = 13.3 years), all with a diagnosis of autism and the majority with a history of demand avoidant behaviour. We also interviewed their parents and teaching staff about the students’ past and current school experiences. All students were currently being educated within an ‘Inclusive Learning Hub’, specially designed to re-integrate excluded, autistic students back into school, which was situated within a larger autism special school. Results Young people and their parents gave overwhelmingly negative accounts of the students’ previous school experiences. Children’s perceived unmet needs, as well as inappropriate approaches by previous school staff in dealing with children’s difficulties, were felt to cause decline in children’s mental health and behaviour and, ultimately, led to their exclusion from school. Four key factors for successful reintegration into school were identified, including (i) making substantial adjustments to the physical environment, (ii) promoting strong staff–student relationships, (iii) understanding students’ specific needs, and (iv) targeted efforts towards improving students’ wellbeing. Conclusion The culmination – and escalation – of challenges students experienced in the students’ previous placements could suggest that the educational journey to exclusion from school is an inevitable consequence for at least some autistic children, including those with particularly complex behaviour, as sampled here. Yet, our study encouragingly showed that this was not necessarily the case. All the young people we spoke to reported being happy, safe and secure in their current placement, and re-engaged with school life. Outstanding issues remain, however, with regard to children’s reportedly slow academic progress and difficulties generalising the positive behaviour shown in school across home and community contexts. Implications More remains to be done to ensure that autistic children and young people’s progress at school is also mirrored in other settings. Future research also needs to develop more preventative approaches to avoid exclusion from school, including efforts towards improving education professionals’ knowledge and awareness of autism, and effective ways of responding to these students’ needs.
Use of the Avegant Glyph Head-Mounted Virtual Retinal Projection Display to Perform Vitreoretinal Surgery
Authors: Korot Edward , Thanos Aristomenis , Todorich Bozho , Rao Prethy , Stem Maxwell S. , Williams George A. 
Published: November 2017

Objective: To evaluate the use of a novel retinal projection display in vitreoretinal surgery. Methods: The Avegant Glyph virtual retinal display, which uses a light-emitting diode and micromirror array to project directly onto the retinas of the user, was evaluated. This unit was modified for better operating room characteristics. It was evaluated by 6 surgeons performing mock vitreoretinal surgeries. Results: The majority reported high 3-dimensional (3-D) depth rendition, little hindrance to communication, and high confidence to perform procedures. Due to a small ocular size, surgeons conveyed that the Glyph provides a novel enhanced view for performing procedures benefiting from simultaneous intra- and extraocular visualization such as scleral depression. Safety analysis by performing fundus autofluorescence after 2 hours of Glyph operation did not reveal any gross qualitative change. Conclusion: Use of the Avegant Glyph to perform vitreoretinal surgery may provide ergonomic advantages, while its visualization and high 3-D stereoscopic depth rendition instill high surgeon confidence to safely perform procedures. We are performing further studies with objective data to validate the potential of this technology.
Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient
Authors: Davies Gwyneth , Stocks Janet , Thia Lena P. , Hoo Ah-Fong , Bush Andrew , Aurora Paul , Brennan Lucy , Lee Simon , Lum Sooky , Cottam Philippa , Miles Joanne , Chudleigh Jane , Kirkby Jane , Balfour-Lynn Ian M. , Carr Siobhán B. , Wallis Colin , Wyatt Hilary , Wade Angie 
Published: November 2017

With the advent of novel designer molecules for cystic fibrosis (CF) treatment, there is huge need for early-life clinical trial outcomes, such as infant lung function (ILF). We investigated the degree and tracking of ILF abnormality during the first 2 years of life in CF newborn screened infants.Forced expiratory volume in 0.5 s (FEV0.5), lung clearance index (LCI) and plethysmographic functional residual capacity were measured at ∼3 months, 1 year and 2 years in 62 infants with CF and 34 controls.By 2 years there was no significant difference in FEV0.5z-score between CF and controls, whereas mean LCI z-score was 0.81 (95% CI 0.45–1.17) higher in CF. However, there was no significant association between LCI z-score at 2 years with either 3-month or 1-year results. Despite minimal average group changes in any ILF outcome during the second year of life, marked within-subject changes occurred. No child had abnormal LCI or FEV0.5on all test occasions, precluding the ability to identify “high-risk” infants in early life.In conclusion, changes in lung function are mild and transient during the first 2 years of life in newborn screened infants with CF when managed according to a standardised UK treatment protocol. Their potential role in tracking disease to later childhood will be ascertained by ongoing follow-up.
Accurate laser scanner to camera calibration with application to range sensor evaluation
Authors: Fuersattel Peter , Plank Claus , Maier Andreas , Riess Christian 
Published: November 2017

Abstract
Multi-modal sensory data plays an important role in many computer vision and robotics tasks. One popular multi-modal pair is cameras and laser scanners. To overlay and jointly use the data from both modalities, it is necessary to calibrate the sensors, i.e., to obtain the spatial relation between the sensors.
Computing such a calibration is challenging as both sensors provide quite different data: cameras yield color or brightness information, laser scanners yield 3-D points. However, several laser scanners additionally provide reflectances, which turn out to make calibration to a camera well feasible. To this end, we first estimate a rough alignment of the coordinate systems of both modalities. Then, we use the laser scanner reflectances to compute a virtual image of the scene. Stereo calibration on the virtual image and the camera image are then used to compute a refined, high-accuracy calibration.
It is encouraging that the accuracies in our experiments are comparable to camera-camera stereo setups and outperform another of other target-based calibration approach. This shows that the proposed algorithm reliably integrates the point cloud with the intensity image. As an example application, we use the calibration results to obtain ground-truth distance images for range cameras. Furthermore, we utilize this data to investigate the accuracy of the Microsoft Kinect V2 time-of-flight and the Intel RealSense R200 structured light camera.