bluuebunny/crossref_metadata_2025_split huggingface dataset:
The safety of Pipeline flow diversion in fusiform vertebrobasilar aneurysms: a consecutive case series with longer-term follow-up from a single US center
Authors: Natarajan Sabareesh K. , Lin Ning , Sonig Ashish , Rai Ansaar T. , Carpenter Jeffrey S. , Levy Elad I. , Siddiqui Adnan H. 
Published: December 2015

OBJECT
Pessimism exists regarding flow diversion for posterior circulation aneurysms because of reports of perforator territory infarcts and delayed ruptures. The authors report the results of patients who underwent Pipeline Embolization Device (PED) flow diversion using novel strategies for treatment of fusiform posterior circulation aneurysms, and compare these results with those from previously reported series.

METHODS
The authors conducted a retrospective review of data from consecutive patients with fusiform vertebrobasilar artery aneurysms treated with the PED.

RESULTS
This review resulted in the identification of 12 such patients (mean [± SD] age 55.1 ± 14.1 years). Eleven patients had symptoms; 1 had a dissecting aneurysm identified on imaging for neck pain. The average aneurysm size was 13.25 ± 4.5 mm. None of the aneurysms were ruptured or previously treated. The average clinical follow-up duration was 22.1 ± 10.7 months and radiological follow-up was 14.5 ± 11.1 months from the index PED treatment. One patient suffered a perforator stroke and had a modified Rankin Scale (mRS) score of 4 at last follow-up. Another patient had a retained stent pusher requiring retrieval via surgical cut-down but recovered to an mRS score of 0 at last follow-up. Eleven (91.7%) of 12 patients recovered to an mRS score of 0 or 1. Two patients had aneurysmal remnants at 7 and 10 months, respectively, after the index PED, which were retreated with PEDs. At last follow-up, all 12 aneurysms were occluded and PEDs were patent. The minimum follow-up duration was 12 months from the index PED treatment; no patient experienced delayed hemorrhage, stroke, or in-stent stenosis.

CONCLUSIONS
Flow diversion with selective adjunctive techniques is evolving to become a safer treatment option for posterior circulation aneurysms. This is the longest clinical follow-up duration reported for a single-center experience of flow-diversion treatment of these aneurysms.
Sonographic findings associated with stenosis progression and vascular complications in moyamoya disease
Authors: Lee Woo-Jin , Jung Keun-Hwa , Lee Keon-Joo , Kim Jeong-Min , Lee Soon-Tae , Chu Kon , Lee Sang Kun , Roh Jae-Kyu 
Published: December 2015

OBJECT
The progression of arterial stenosis in patients with moyamoya disease (MMD) has variable courses and an unclear mechanism. The authors hypothesized that elevated wall shear stress (WSS) at the terminal internal carotid artery (ICA) and proximal middle cerebral artery (MCA) may facilitate MMD progression. They indirectly evaluated the relative magnitude of WSS (WSS value [WSSV]) with MR angiography (MRA) and transcranial Doppler to determine its predictive value for stenosis progression (SP) and the development of vascular complications.

METHODS
Thirty-one medically treated patients (58 hemispheres and 95 nonoccluded vessels) were analyzed with serial MRA (median follow-up 23 months). The parameters studied were SP, SP rates (SPRs) for individual ICAs/MCAs, and their mean values from the ipsilateral hemispheres as mean SP (MSP) and MSP rates (MSPRs). Significant progression was defined as decrements of ≥ 20% for SP and MSP and ≥ 10%/year for SPR and MSPR. The development of vascular complications in relevant hemispheres was also recorded. The WSSV (dyne/cm2) was defined as the shear rate multiplied by blood viscosity.

RESULTS
After adjusting the initial stenosis degree and MRA stage of MMD, an SP of ≥ 20% and an SPR of ≥ 10%/year were associated with the highest-quartile WSSVs for all individual vessels and for MCAs and ICAs separately. For each hemisphere, an MSP of ≥ 20% and an MSPR of ≥ 10%/year were associated with the highest-quartile mean WSSVs. Furthermore, significant SP was highly correlated with vascular complications, and the highest-quartile mean WSSV was independently associated with vascular complications in relevant hemispheres.

CONCLUSIONS
An elevated WSSV is an independent predictor for SP and vascular complications in nonoccluded MMD.
Newly onset: sudden & severe headache in a patient who overused analgesic
Authors: Mat Khairi Che , Husain Rohayah , Mohamad Nasir 
Published: December 2015

This case report presented a rare cause of severe headache in a patient who developed episodes of acute severe headache for the first time. The earliest accurate provisional diagnosis is crucial for a new onset severe headache in adult. A good history taking and high index of suspicious are remained the most important clinical component in managing severe first time headache in adult. The differential diagnosis of subarachnoid hemorrhage, space-occupying lesion with increased intracranial pressure, acute intoxication, meningo-encephalitis and others must be ruled out as these conditions are benefited in early management. In this patient, progressive development of headache is masked by severe intense headache, which later will be described as acute headache. The causes of newly onset severe intense headache will be discussed in the discussion.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.399-401
Citizen Science: The First Peninsular Malaysia Butterfly Count
Authors: Wilson John-James , Jisming-See Shi-Wei , Brandon-Mong Guo-Jie , Lim Aik-Hean , Lim Voon-Ching , Lee Ping-Shin , Sing Kong-Wah 
Published: December 2015

Over the past 50 years, Southeast Asia has suffered the greatest losses of biodiversity of any tropical region in the world. Malaysia is a biodiversity hotspot in the heart of Southeast Asia with roughly the same number of mammal species, three times the number of butterfly species, but only 4% of the land area of Australia. Consequently, in Malaysia, there is an urgent need for biodiversity monitoring and also public engagement with wildlife to raise awareness of biodiversity loss. Citizen science is “on the rise” globally and can make valuable contributions to long-term biodiversity monitoring, but perhaps more importantly, involving the general public in science projects can raise public awareness and promote engagement. Butterflies are often the focus of citizen science projects due to their charisma and familiarity and are particularly valuable “ambassadors” of biodiversity conservation for public outreach.
Here we present the data from our citizen science project, the first “Peninsular Malaysia Butterfly Count”. Participants were asked to go outdoors on June 6, 2015, and (non-lethally) sample butterfly legs for species identification through DNA barcoding. Fifty-seven citizens responded to our adverts and registered to take part in the butterfly count with many registering on behalf of groups. Collectively the participants sampled 220 butterfly legs from 26 mostly urban and suburban sampling localities. These included our university campus, a highschool, several public parks and private residences. On the basis of 192 usable DNA barcodes, 43 species were sampled by the participants. The most sampled species was Appias olferna, followed by Junonia orithya and Zizina otis. Twenty-two species were only sampled once, five were only sampled twice, and four were only sampled three times. Three DNA barcodes could not be assigned species names. The sampled butterflies revealed that widely distributed, cosmopolitan species, often those recently arrived to the peninsula or with documented "invasive" potential, dominated the habitat types sampled by the participants. Data from this first Butterfly Count helps establish a baseline from which we can monitor the patterns and changes in butterfly communities in Peninsular Malaysia.
Évaluation projective de la qualité du narcissisme à l’adolescence : comparaison de patientes névrosées et états limites
Authors: Hurvy Caroline , Cohen de Lara Aline 
Published: December 2015

L’étude qualitative des manifestations du narcissisme aux épreuves projectives est apparue pertinente pour rendre compte de certaines particularités du fonctionnement psychique d’un groupe de patientes adolescentes névrotiques comparées à un groupe de patientes états limites. Étant donné les profonds remaniements des investissements objectaux nécessités par l’avènement de la puberté, l’adolescence est une période au cours de laquelle les assises narcissiques du sujet sont fortement mises à l’épreuve. Si dans les deux groupes des fragilités narcissiques sont présentes, celles-ci diffèrent quant à leur place et leur fonction dans l’économie psychique globale. À travers l’étude de certains aspects du narcissisme – le type d’investissement des limites entre dedans et dehors, la qualité de l’introjection objectale sous-jacente – et de ses incidences sur le traitement de la problématique de perte d’objet seront discutées les caractéristiques différentielles de ces deux modes d’organisation, névrotique et limite.
Les enjeux de l’Accueil provisoire jeune majeur pour les jeunes majeurs parisiens
Authors: Garrigues Hélène 
Published: December 2015

Nous assistons à un intérêt croissant quant au devenir des enfants, adolescents et jeunes majeurs ayant bénéficié d’une mesure de placement dans le cadre de la protection de l’enfance. Ce qui ressort de l’ensemble de ces recherches, c’est que les principales difficultés d’insertion rencontrées par les jeunes à la sortie des dispositifs de protection de l’enfance se situent autour du passage à l’âge adulte et de son corollaire : l’autonomie. Face à ces difficultés, il paraît alors pertinent d’étudier, en parallèle du devenir de ces jeunes, l’accompagnement vers l’autonomie qui leur est proposé durant leur prise en charge, et notamment dans le cadre du dispositif d’Accueil provisoire jeune majeur ( apjm ), mais également comment ils vivent cet accompagnement. Cet article tente de comprendre quelle est l’expérience vécue par les jeunes de 18 à 21 ans pris en charge dans le cadre d’un apjm , et ce qu’ils font de l’accompagnement vers l’autonomie qui leur est proposé.
Mieux préparer et accompagner les « jeunes sortants » de la protection de l’enfance et de la Protection judiciaire de la jeunesse pour une réelle inclusion sociale
Authors: Sourmais Laure , Pallez Audrey 
Published: December 2015

Si le passage à l’âge adulte constitue un moment décisif pour tous les jeunes, la situation est particulièrement alarmante pour les « jeunes sortants » de la protection de l’enfance et de la Protection judiciaire de la jeunesse. Pour ces derniers, le passage à la majorité signifie, le plus souvent, l’arrêt brutal de l’accueil et de l’accompagnement éducatif. Il est donc essentiel de soutenir leur parcours vers l’âge adulte, non seulement d’un point de vue politique et législatif, mais surtout en repensant les pratiques. L’objectif est que tous les jeunes entre 16 et 18 ans soient préparés progressivement à la sortie du dispositif et qu’il leur soit proposé, à leur majorité, un accompagnement dans l’âge adulte.
Ebola en Guinée : violences historiques et régimes de doute
Authors: Fribault Mathieu 
Published: December 2015

Cet article fait l’hypothèse que les « réticences » et les « rumeurs » qui s’observent en Guinée dans le cadre de la Maladie à Virus Ebola (MVE), et qui ne semblent pas s’affaiblir plus d’une année et demie après la déclaration de l’épidémie, peuvent s’inscrire et être analysées dans le droit fil des violences qui ont caractérisé l’histoire de la sous-région durant plusieurs siècles. Selon cette hypothèse, les Guinéens expérimenteraient l’épidémie ainsi que sa prise en charge, à partir de ces expériences passées, comme de nouvelles violences politiques. La notion de « démystification » liée à un programme étatique post-indépendance des années 60, qui visait la suppression du « fétichisme » et la fabrication d’une citoyenneté nationale, est le fil conducteur permettant de comparer les violences passées et la crise épidémique d’aujourd’hui ainsi que les réponses que les sociétés guinéennes y ont apporté et y apportent toujours.
La Fièvre Hémorragique à Virus Lassa au Bénin en 2014 en contexte d’Ebola : une épidémie révélatrice de la faiblesse du système sanitaire
Authors: N’koué Sambiéni Emmanuel , Danko Nouratou , Ridde Valéry 
Published: December 2015

L’histoire de la gestion de l’épidémie de fièvre hémorragique à virus Lassa (FHVL), survenue au Bénin en 2014, se situe dans un contexte d’épidémie à virus Ebola en Afrique de l’Ouest. La présente recherche vise à comprendre les conditions sociales du déclenchement et de l’évolution de l’épidémie de FHVL, d’une part, et les processus techniques, politiques et institutionnels de sa gestion par l’État et le réseau international d’alerte et de riposte sanitaire, d’autre part. L’enquête de terrain s’est déroulée sur plusieurs sites : au ministère de la santé à Cotonou, dans les services de santé (dont l’hôpital Saint-Jean de Dieu de Tanguiéta au Nord du pays), et dans les familles de l’aire géographique de l’épidémie. L’enquête qualitative a associé des observations directes dans les milieux sociaux et hospitaliers, des entretiens semi-structurés et la recension d’articles scientifiques, de littérature grise et de presse. L’article suggère qu’au plan institutionnel et médical, l’État a fait preuve de faiblesse dans la riposte d’urgence, surtout en matière de communication et de diagnostic. Du côté des populations et des agents de santé, les symptômes vus, entendus ou appris ont été interprétés selon les modèles étiologiques locaux de la maladie, empreints de logiques magico-religieuses. L’offre privée confessionnelle de santé, malgré ses forces et sa réputation, est encore peu outillée pour réagir rapidement à une épidémie d’urgence comme celle-ci. Les structures décentralisées du système de soins ne se sont pas appropriés leurs rôles. L’État manque d’un système de surveillance et de capacités de gestion des épidémies d’urgence.
Qui décide ici ? Le comportementalisme dans le système carcéral américain
Authors: Rhodes Lorna A. 
Published: December 2015

Lorsque les employés de la prison décrivent un « comportement » ou désignent un prisonnier comme « comportemental (behavioral) », ils font référence à des actes d’agression ou d’auto-agression extrêmes et en apparence irrationnels. Ces « comportements », à la frontière entre l’indiscipline et la folie, ne relèvent ni explicitement de la responsabilité du personnel de surveillance, ni du personnel soignant. Ils constituent un trouble continuel et insoluble au sein du dispositif institutionnel, mobilisant d’importants moyens (en personnels ou en infrastructure spécialisée). Pourtant, le « comportement » constitue aussi une ressource pour la prison qui recourt à une vision simplifiée du comportementalisme afin d’établir le contrôle sur les individus. En s’appuyant sur une enquête ethnographique dans des unités pénitentiaires psychiatriques qui mettent en œuvre des pratiques de gestion comportementale, cet article vise à montrer comment le « comportement » exprime la relation problématique entre le contrôle et l’action individuelle, tension qui imprègne l’ensemble du complexe carcéral.
Emergence of micronuclei as a genomic biomarker
Authors: Sabharwal Robin , Verma Parul , Syed Mohammed Asif , Sharma Tamanna , Subudhi Santosh Kumar , Mohanty Saumyakanta , Gupta Shivangi 
Published: December 2015

AbstractThe presence of micronuclei (MN) in mammalian cells is related to several mutagenetic stresses. MN are formed as a result of chromosome damage and can be readily identified in exfoliated epithelial cells. MN is chromatin particles derived from acentric chromosomal fragments, which are not incorporated into the daughter nucleus after mitosis. It can be visualized by chromatin stains. A variety of factors influences the formation of MN in cells such as age, sex, genetic constitution, physical and chemical agents, adverse habits such as tobacco, areca nut chewing, smoking, and alcohol consumption. Micronucleation has important implications in the genomic plasticity of tumor cells. The present paper reviews the origin, fate and scoring criteria of MN that serves as a biomarker of exposure to genetic toxins, and for the risk of cancer.
Clinical implication of thiopurine methyltransferase polymorphism in children with acute lymphoblastic leukemia: A preliminary Egyptian study
Authors: El-Rashedy Farida H. , Ragab Seham Mohammed , Dawood Ashraf A. , Temraz Shaymaa A. 
Published: December 2015

Abstract
Background: 6-mercaptopurine (6-MP) is an essential component of pediatric acute lymphoblastic leukemia (ALL) maintenance therapy. Individual variability in this drug-related toxicity could be attributed in part to genetic polymorphism thiopurine methyltransferase (TPMT). Aim: To investigate the frequency of common TPMT polymorphisms in a cohort of Egyptian children with ALL and the possible relation between these polymorphisms and 6-MP with short-term complications. Materials and Methods: This study included 25 children. Data related to 6-MP toxicity during the maintenance phase were collected from the patients′ files. DNA was isolated and genotyping for TPMT G460A, and A719G mutations were performed by polymerase chain reaction-restriction fragment length polymorphism. Results: Twenty (80%) of the included 25 patients had a polymorphic TPMT allele. TPMTFNx013A was the most frequent (14/25, 56%), 8 patients were homozygous and 6 were heterozygous. TPMTFNx013C mutant allele was found in 4 patients (16%) in the heterozygous state while 2 patients (8%) were found to be heterozygous for TPMTFNx013B mutant allele. TPMT mutant patients, especially homozygous, were at greater risk of 6-MP hematological toxicity without significant difference regarding hepatic toxicity. Conclusions: TPMT polymorphism was common among the studied group and was associated with increased risk of drug toxicity. A population-based multi-center study is required to confirm our results.
Intérêt et applications du Cross-Linking du colagène cornéen en ophtalmologie vétérinaire
Authors: Famose Frank 
Published: December 2015

Corneal collagen cross-linking : interests and applications in veterinary ophthalmology.
Corneal collagen cross-linking (CXL) is a photochemical process based on the production of free radicals by a chromophore (riboflavin) after activation by a UVA beam. Corneal effects are as follows : improvement of the corneal strength and of its resistance to enzymatic digestion, inactivation of in situ microbial germs and modulation of the corneal inflammatory response. Veterinary applications of this process are adapted from human ophthalmology and consist first in the treatment of confirmed or supposed corneal infections. PACK-CXL (Photo-Activated Chromophore for Keratitis – CXL) is a serious option for the treatment of corneal melts in dogs, cats and horses and can replace tectonic surgery. The second application is the treatment of bullous keratopathy in canine patients for which the CXL provides the symptomatic relief of the chronic corneal ulceration although corneal edema remains unchanged.
Optically isolated current source
Authors: Pettersen F. J. , Høgetveit J. O. 
Published: December 2015

Abstract
There is a need for isolated current sources for use in selected bioimpedance measurement circuits. The requirement for good isolation is particularly important in medical settings because of safety concerns. A new circuit for producing voltage-controlled current is presented. Measurements have been made on a prototype and simulations have been done on a SPICE model. The presented circuit is an H-bridge where the output devices are the output photodiodes of high-linearity optocouplers. Five operational amplifiers, four high linearity optocouplers, and passive components are used. Output current capability is ±35 μA with an output impedance that is more than 1 M Ω. It is possible to achieve bandwidths above 1 MHz for small load impedances. This circuit is well suited for medical applications thanks to the isolation in the optocouplers.
Rapid Enantiomeric Separation and Quantitation of Levetiracetam on α-Acid Glycoprotein (AGP) Chiral Stationary Phase by High-Performance Liquid Chromatography
Authors: Heydari Rouhollah , Shamsipur Mojtaba 
Published: December 2015

Abstract
A new, simple, and rapid chiral HPLC method was developed for enantioselective analysis of levetiracetam and its enantiomer [(R )-α-ethyl-2- oxo-pyrrolidine acetamide] in a pharmaceutical formulation and bulk material. Enantiomeric separation was achieved on a chiral-α1 -acid glycoprotein (AGP) column (150 × 4.0 mm, 5 μm) using an isocratic mobile phase of phosphate buffer (pH = 7) at a flow rate of 0.7 mL/min. The UV detector was set at 210 nm. Calibration curves were linear in the range of 1–100 μg/mL and 0.4–20 μg/mL for levetiracetam and the (R)-enantiomer, respectively. LOD and LOQ for the (R)-enantiomer were 0.1 and 0.4 μg/mL, respectively. The run time of analysis was less than 5.0 min.
An Interlaboratory Comparative Study on the Quantitative Determination of Glyphosate at Low Levels in Wheat Flour
Authors: Simonetti Emanuela , Cartaud Gérald , Quinn Robert M , Marotti Ilaria , Dinelli Giovanni 
Published: December 2015

Abstract
In recent years, the use of glyphosate has dramatically increased worldwide, and there is growing concern about contamination of organic products caused by its heavy use on neighboring fields. Glyphosate is found as a residue not only in soil, plants, and groundwater but also in humans and animals. Considering the controversy on glyphosate maximum residue level in foodstuff and the difficulties in its analytical determination, the main purpose of the present paper was to investigate the competence and accuracy of 13 accredited European laboratories in determining glyphosate in wheat flour at a level close to their reporting limit of 10 μg/kg. According to the results of this performance assessment, the laboratories were not able to quantify glyphosate at trace levels. Therefore, their specified reporting limits of 10 μg/kg were not supported by their results, and a reporting limit of around 50 μg/kg of glyphosate in flour seems to be more appropriate to guarantee reliable and robust results. The widespread use of glyphosate and its harmfulness to humans make its detection at trace levels a primary goal for analytical laboratories. This is achievable through the improvement of QA and/or the optimization of the method of analysis used for glyphosate detection.
Data Quality in Biofilm High-Throughput Routine Analysis: Intralaboratory Protocol Adaptation and Experiment Reproducibility
Authors: Jorge Paula , Lourenço Anália , Pereira Maria Olívia 
Published: December 2015

Abstract
Biofilm research is growing more diverse and dependent on high-throughput technologies, and the large-scale production of results aggravates data substantiation. In particular, experimental protocols are often adapted to meet the needs of a particular laboratory, and no statistical validation of the modified method is provided. This paper discusses the impact of intralaboratory adaptation and non-rigorous documentation of experimental protocols on biofilm data interchange and validation. The case study is a non-standard, but widely used, workflow for Pseudomonas aeruginosa biofilm development considering three analysis assays: the crystal violet (CV) assay for biomass quantification, the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide inner salt (XTT) assay for respiratory activity assessment, and the colony forming units (CFU) assay for determination of cell viability. The ruggedness of the protocol was assessed by introducing small changes in the biofilm growth conditions, which simulate minor protocol adaptations and non- rigorous protocol documentation. Results show that even minor variations in the biofilm growth conditions may affect the results considerably, and that the biofilm analysis assays lack repeatability. Intralaboratory validation of non-standard protocols is found critical to ensure data quality and enable the comparison of results within and among laboratories.