bluuebunny/crossref_metadata_2025_split huggingface dataset:
No effect of HLA‐C mismatch after allogeneic hematopoietic stem cell transplantation with unrelated donors and T‐cell depletion in patients with hematological malignancies
Authors: Magalhaes Isabelle , Uhlin Michael , Schaffer Marie , Sundin Mikael , Hauzenberger Dan , Remberger Mats , Mattsson Jonas 
Published: May 2017

AbstractHLA‐C mismatch in unrelated donor's hematopoietic stem cell transplantation (HSCT) has been associated with poor patient outcome. However, the impact of HLA‐C mismatch in the context of HSCT combined with in vivo T‐cell depletion remains unclear. We therefore performed a single‐center, retrospective analysis of the clinical outcome on patients with hematological malignancies treated with allo‐HSCT, who underwent T‐cell depletion. The majority of the patients (n=276) received a HLA‐A, HLA‐B, HLA‐DRB1‐matched graft that were either also HLA‐C matched (n=260), or patients with the permissive HLA‐C*03:03/03:04 mismatch (n=16), while the remaining patients (n=95) received a HLA‐C‐mismatched graft (excluding HLA‐C*03:03/03:04 mismatches). We did not observe any significant differences between the HLA‐C‐matched patients (including the permissive HLA‐C*03:03/03:04 mismatch) and the HLA‐C‐mismatched patients regarding cumulative proportion surviving, graft failure, relapse‐free survival, relapse, or acute graft‐versus‐host disease. Our data suggest that in the context of high dose T lymphocyte‐depleting agents, HLA‐C matching is not essential for patients with hematological malignancies.
Post‐genocide justice: The Gacaca courts
Authors: O’Reilly Colin , Zhang Yi 
Published: May 2017

AbstractIn the aftermath of the Rwandan genocide, the crippled formal judicial system failed to administer justice in a timely manner. A modified version of the traditional Gacaca courts was introduced to hear cases from the backlog of over 100,000 genocide suspects. We find that the Gacaca courts performed well relative to the formal justice system, given the constraints faced. The Gacaca courts generated valuable information about the genocide suspects and increased access to the justice system. The introduction of the Gacaca courts improved the performance of the formal justice system and facilitated post‐conflict recovery.
Optimising taxonomic effort to overcome the Linnean shortfall: the case of European leaf beetles
Authors: Freijeiro Andrea , Gómez‐Rodríguez Carola , Castro‐Insua Adrián , Baselga Andrés 
Published: May 2017

Abstract

Assessing the factors that govern the probability of a species (i) being discovered and (ii) being described under different names can help to improve the efficiency of future taxonomic efforts.

Here, we assess whether species body size, extent of distribution and geographical position affect the probabilities of discovery and redundant description of European Chrysomelidae (Coleoptera).

The probability of description of European Chrysomelidae is determined mostly by the characteristics of the species distribution but not by body size; species with broad and northern distributions have been described before.

The probability of redundant description is mainly related to the year of description; species with a higher number of synonyms were described earlier and have broader distributions.

The extrapolation of the observed trends suggests that undescribed species of Chrysomelidae have narrow distributions and live in southern Europe and that recently described species have a low number of synonyms because the efficiency of leaf beetle taxonomy has increased over time.
Spray drying conditions for orange juice incorporated with lactic acid bacteria
Authors: Barbosa Joana , Brandão Teresa R. S. , Teixeira Paula 
Published: May 2017

SummaryThis work aimed to develop an orange juice powder by spray drying with lactic acid bacteria (Lactobacillus plantarum 299v and Pediococcus acidilactici HA‐6111‐2), testing their survival both during drying and storage (room temperature and 4 °C). Initially, the best conditions for spray drying were chosen to allow the best survival of each LAB: (i) inlet air temperature of 120 °C and (ii) 0.5:2 ratio of the orange juice soluble solids and drying agent added (prebiotics: 10 DE maltodextrin or gum Arabic). Survival of LAB was not affected by drying process, and it was higher when cultures were stored at 4 °C. A slightly higher protection was conferred by 10 DE maltodextrin, in the case of L. plantarum and at 4 °C. Pediococcus acidilactici was more resistant during storage at 4 °C, with logarithmic reductions lower than 1 log‐unit. It was demonstrated that it is possible to produce a functional nondairy product, orange juice powder supplemented with prebiotic compounds, containing viable LAB for at least 7 months, when stored at 4 °C.
Exploring Cryptic Diversity and Distribution Patterns in the Mallomonas kalinae/rasilis Species Complex with a Description of a New Taxon—Mallomonas furtiva sp. nov.
Authors: Gusev Evgeniy S. , Čertnerová Dora , Škaloudová Magda , Škaloud Pavel 
Published: May 2017

AbstractA complex of closely related Mallomonas taxa belonging to the section Papillosae, M. kalinae Řezáčová and M. rasilis Dürrschmidt, has been studied in detail by molecular and morphometric methods. Our investigations uncovered the existence of a new species found in water bodies in Vietnam, which we describe here as Mallomonas furtiva sp. nov. This taxon is morphologically very similar to M. kalinae, from which it differs by minute, but statistically significant morphological differences on the structure of silica scales. Indeed, the principal component analysis of morphological traits measured on silica scales significantly separates all three species in the complex. Mallomonas kalinae and M. furtiva differ by number of papillae on the shield and the dome, as well as by the scale sizes. Likewise, Mallomonas rasilis and M. furtiva are primarily differentiated by the absence of submarginal anterior ribs on silica scales of the former species. Phylogenetic analyses showed that Mallomonas furtiva is closely related to M. kalinae, with which it formed a highly supported lineage. Distribution patterns of all three studied taxa are further discussed.
Ayni Unbounded: Cooperation, Inequality, and Migration in the Peruvian Andes
Authors: Paerregaard Karsten 
Published: May 2017

ResumenConvencionalmente, los antropólogos han estudiado ayni como una práctica de igualdad. Este artículo examina la cooperación andina como una gramática de reciprocidad que encubre tanto una ideología de igualdad como una práctica de diferencia. Analizando datos de trabajo de campo en una comunidad andina y su colonia de migrantes en los EE.UU. el artículo investiga las relaciones de ayni que los migrantes transnacionales utilizan para patrocinar las fiestas de su comunidad de origen y la estructura de poder en las cuales estas relaciones son incrustadas. Sostiene que cuando los migrantes demuestran su riqueza y competen para ganar prestigio en la fiesta revelan la desigualdad de ayni. Sugiere que a diferencia de la reciprocidad presentada en las etnografías andinas la cooperación entre migrantes es exclusiva y refuerza las relaciones de dominancia. Concluye que futuros estudios tienen que examinar el contexto económico y político en la cual ayni se envuelve.
Usefulness of techniques based on real time PCR for the identification of onychomycosis‐causing species
Authors: Hafirassou Anissa Z. , Valero Clara , Gassem Nadia , Mihoubi Ilhem , Buitrago Maria J. 
Published: May 2017

SummaryOnychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT‐PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Conventional methods and four different RT‐PCR assays were used: a panfungal, a pandermatophyte and two specific assays for detecting Candida spp. and Aspergillus spp. Fungal elements were visualised in 58% of the samples, and 54% of cultures were positive. Panfungal and pandermatophyte RT‐PCR were positive in 28% and 60%, respectively, and the sensitivity relative to positive cultures was 47% and 90%. Candida spp. were detected in 76% of samples analysed and Aspergillus spp. in 60%. These species were also present in 80% of control cases. In conclusion, molecular techniques were useful but showed limitations. The panfungal assay showed a low sensitivity, the pandermatophyte assay was sensitive and specific but did not allow for differentiation among species of dermatophytes. Finally, the role of non‐dermatophyte species detected by using specific RT‐PCR techniques should be carefully analysed as these species were also present in healthy nails.
A re‐audit to assess the incidence of alveolar osteitis within the Oral Surgery Department of a teaching hospital
Authors: Qalandari Mohamed Afzal , Dargue Anna 
Published: May 2017

AbstractAimAlveolar osteitis (AO) is one of the most common post‐operative complications following tooth removal. It is associated with significant patient morbidity and an increase in post‐operative visits. Thus, establishing the incidence of AO within the Oral Surgery Department of Bristol Dental Hospital and reviewing this in the light of the Cochrane systematic review, which suggests an incidence of 5% for routine extractions, is important.Material and MethodsThis article shares the results of three audit cycles assessing the incidence of AO, comparing the findings and discussing them in terms of the relevant literature. Data were collected for a period of 1 month for all patients undergoing routine extractions under local anaesthetic performed by both staff and students.ResultsOne hundred and forty‐four routine extractions were carried out on 89 patients during the audit period, with 55% of the extractions being performed by students and 45% by members of staff with varying levels of experience from DCT1 up to Associate Specialist. 4.8% (7/144) of patients returned with post‐operative complications resulting in a diagnosis of AO. 71% of extractions resulting in AO were performed by students and this was identical to the incidence noted in a 2003 audit. 64% of AO occurred in mandibular teeth.ConclusionRecent audits of AO incidence in the Oral Surgery Department of Bristol Dental Hospital indicate an acceptable level of occurrence, under the 5% target. The audits highlight operator experience and the location of the extraction site as contributing factors for the development of AO. This has implications for the clinical governance of the service, and students must be appropriately supervised to ensure high‐quality patient care.
Pollinators shift to nectar robbers when florivory occurs, with effects on reproductive success in Iris bulleyana (Iridaceae)
Authors: Ye Z.‐M. , Jin X.‐F. , Wang Q.‐F. , Yang C.‐F. , Inouye D. W. 
Published: May 2017

Abstract

Studies have indicated that florivory and nectar robbing may reduce reproductive success of host plants. However, whether and how these effects might interact when plants are simultaneously attacked by both florivores and nectar robbers still needs further investigation.

We used Iris bulleyana to detect the interactions among florivory, nectar robbing and pollination, and moreover, their effects on plant reproductive success. Field investigations and hand‐pollination treatments were conducted on two experimental plots from a natural population, in which Experimental plot was protected from florivores and Control plot was not manipulated.

The flower calyx was bitten by sawflies to consume the nectary, and three bumblebee species were pollinators. In addition, the short‐tongued pollinator, Bombus friseanus, was the only robber when there was a hole made by a sawfly. The bumblebee had significantly shortened flower handling time when robbing, as compared to legitimate visits. Pollinator visitation and seed production decreased significantly in damaged flowers. However, seed production per flower after supplementary hand‐pollination did not differ significantly between damaged and undamaged flowers. Compared to the Experimental plot, bumblebees visited fewer flowers per plant in a foraging bout in the Control plot.

The flowers damaged by florivory allowed B. friseanus to shift to a nectar robber. Florivory and nectar robbing collectively decreased plant reproductive success by consuming nectar resources, which may reduce attractiveness to pollinators of the damaged flowers. However, the changes in pollinator behaviour might be beneficial to the plant by reducing the risk of geitonogamous mating.
Temporary legislation, better regulation, and experimentalist governance: An empirical study
Authors: Bar‐Siman‐Tov Ittai 
Published: May 2017

AbstractThis article presents the findings of an extensive multi‐method empirical study that explored the relationship between temporary legislation, better regulation, and experimentalist governance. Temporary (or “sunset”) legislation – statutory provisions enacted for a limited time and set to expire unless their validity is extended – is often hailed as a key tool for promoting experimental and better regulation. Despite the importance of temporary legislation and the burgeoning theoretical scholarship on the subject, there is still a dearth of empirical studies about how temporary legislation is used in practice. The lack of empirical evidence creates a lacuna in at least three areas of theoretical scholarship, concerning temporary legislation, better regulation, and experimentalist governance. This paper is a first step to fill this gap.
Dignity‐conserving care actions in palliative care: an integrative review of Swedish research
Authors: Harstäde Carina Werkander , Blomberg Karin , Benzein Eva , Östlund Ulrika 
Published: May 2017

BackgroundPrevious research has proposed that persons in need of palliative care often have a loss of functions and roles that affects social and existential self‐image. Moreover, these individuals also commonly suffer from complex multisymptoms. This, together with the situation of facing an impending death, can lead to a loss of dignity. Therefore, supporting these persons’ dignity is a crucial challenge for professional nurses. The ‘Dignity Care Intervention’ addresses the multidimensionality of dignity by identifying patients’ dignity‐related concerns and suggests care actions to address them. At the present, the Dignity Care Intervention is adapted for implementation in Swedish care settings. Because expressions of dignity are influenced by culture, and an overview of care actions in a Swedish context is lacking, this integrative review aimed to find suggestions from Swedish research literature on what kind of care actions can preserve dignity.MethodsAn integrative literature review was conducted using the databases SwePub and SweMed+. Articles published from 2006 to 2015 and theses published from 2000 to 2015 were searched for using the terms ‘dignity’ and ‘palliative care’. Result sections of articles and theses were reviewed for dignity‐conserving care actions synthesised by thematic analysis and categorised under themes and subthemes in Chochinov's model of dignity.ResultsFifteen articles and 18 theses were included together providing suggestions of care actions in all themes and subthemes in the dignity model. Suggested care actions included listening, communication, information, symptom control, facilitating daily living and including patients in decision‐making. Additionally, nurses’ perceptiveness towards the patients was a core approach.ConclusionThe review offers culturally relevant suggestions on how to address specific dignity‐related concerns. The adapted Dignity Care Intervention will be a way for Swedish nurses to provide person‐centred palliative care that will conserve patients’ dignity.
Mobilities, Fixities and Stabilities in Rural Pennsylvania's Natural Gas Boomtowns: Re‐Conceptualising Boomtown Development Through a Mobilities Lens
Authors: Burfoot‐Rochford Ian , Schafft Kai A. 
Published: May 2017

AbstractThe mobilities ‘turn’ within human geography and the social sciences has drawn attention to the ways in which social connections and interactions variously transcend, undo and reconfigure spatial boundaries and identities. In this study we utilise mobilities theory to analyse Marcellus Shale gas boomtown growth in Pennsylvania and the experiences of local residents living in these boomtown areas. We use data from interviews conducted in two rural counties of Pennsylvania to examine the intersection and interaction between diverse boomtown mobilities and local places. We use mobilities theory to illustrate the extent to which local experience of boomtown development is a product of the interaction between the particularities of material and ideological rural community characteristics perceived as more or less ‘fixed’, and the various externally‐originating mobilities associated with local industrial buildout.
Barriers to obstetric fistula treatment in low‐income countries: a systematic review
Authors: Baker Zoë , Bellows Ben , Bach Rachel , Warren Charlotte 
Published: May 2017

AbstractObjectiveTo identify the barriers faced by women living with obstetric fistula in low‐income countries that prevent them from seeking care, reaching medical centres and receiving appropriate care.MethodsBibliographic databases, grey literature, journals, and network and organisation websites were searched in English and French from June to July 2014 and again from August to November 2016 using key search terms and specific inclusion and exclusion criteria for discussion of barriers to fistula treatment. Experts provided recommendations for additional sources.ResultsOf 5829 articles screened, 139 were included in the review. Nine groups of barriers to treatment were identified: psychosocial, cultural, awareness, social, financial, transportation, facility shortages, quality of care and political leadership. Interventions to address barriers primarily focused on awareness, facility shortages, transportation, financial and social barriers. At present, outcome data, though promising, are sparse and the success of interventions in providing long‐term alleviation of barriers is unclear.ConclusionResults from the review indicate that there are many barriers to fistula treatment, which operate at the individual, community and national levels. The successful treatment of obstetric fistula may thus require targeting several barriers, including depression, stigma and shame, lack of community‐based referral mechanisms, financial cost of the procedure, transportation difficulties, gender power imbalances, the availability of facilities that offer fistula repair, community reintegration and the competing priorities of political leadership.
The DNA translocase RAD5A acts independently of the other main DNA repair pathways, and requires both its ATPase and RING domain for activity in Arabidopsis thaliana
Authors: Klemm Tobias , Mannuß Anja , Kobbe Daniela , Knoll Alexander , Trapp Oliver , Dorn Annika , Puchta Holger 
Published: May 2017

SummaryMultiple pathways exist to repair DNA damage induced by methylating and crosslinking agents in Arabidopsis thaliana. The SWI2/SNF2 translocase RAD5A, the functional homolog of budding yeast Rad5 that is required for the error‐free branch of post‐replicative repair, plays a surprisingly prominent role in the repair of both kinds of lesions in Arabidopsis. Here we show that both the ATPase domain and the ubiquitination function of the RING domain of the Arabidopsis protein are essential for the cellular response to different forms of DNA damage. To define the exact role of RAD5A within the complex network of DNA repair pathways, we crossed the rad5a mutant line with mutants of different known repair factors of Arabidopsis. We had previously shown that RAD5A acts independently of two main pathways of replication‐associated DNA repair defined by the helicase RECQ4A and the endonuclease MUS81. The enhanced sensitivity of all double mutants tested in this study indicates that the repair of damaged DNA by RAD5A also occurs independently of nucleotide excision repair (AtRAD1), single‐strand break repair (AtPARP1), as well as microhomology‐mediated double‐strand break repair (AtTEB). Moreover, RAD5A can partially complement for a deficient AtATM‐mediated DNA damage response in plants, as the double mutant shows phenotypic growth defects.
The macroeconomic role of currency reserve accumulation in emerging markets—The Asian experience
Authors: Beckmann Joscha , Berger Theo , Czudaj Robert 
Published: May 2017

AbstractThe impact of currency reserve accumulation is controversially discussed since reserve accumulation potentially destabilises the international financial system and causes crises due to higher systemic risk. The main aim of this paper is to put the macroeconomic role of currency reserve accumulation for four Asian economies under closer scrutiny. The key question is whether accumulating currency reserves is beneficial from a long‐run perspective. Based on a vector error correction approach, we start by analysing long‐run steady‐state relationships between currency reserves, exchange rates against theUSdollar, realGDPand interest rates. Our findings show that cumulated currency reserve shocks significantly affect realGDP. A likely explanation for our finding is that accumulation of reserves has supported growth through providing liquidity and supporting the development of the financial sector for the economies under observation.
Cytologic features of a feline inductive odontogenic tumor
Authors: Leite‐Filho Ronaldo V. , Tagliari Nelson J. , Grandi Fabrizio , Laisse Cláudio J. M. , Gerardi Daniel G. , Pavarini Saulo P. 
Published: May 2017

AbstractThe feline inductive odontogenic tumor (FIOT) is a rare entity among oral tumors in cats, the cytologic features of which are not well characterized but may prove useful. A fine‐needle aspiration biopsy was performed on the right mandible between the permanent canine (404) and permanent fourth premolar (408) of an 8‐month‐old female mongrel cat. Cytologic smears showed epithelial cells and occasional spindle cells with extracellular homogenous acidophilic material in a hematic background. The initial diagnosis of benign tumor was confirmed by histopathologic examination of the biopsy specimen. This report describes the cytologic findings in a case of FIOT.
Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs
Authors: Craik Veronica B. , Johnson Alexander D. , Lohse Matthew B. 
Published: May 2017

ABSTRACT

White and opaque cells of
Candida albicans
have the same genome but differ in gene expression patterns, metabolic profiles, and host niche preferences. We tested whether these differences, which include the differential expression of drug transporters, resulted in different sensitivities to 27 antifungal agents. The analysis was performed in two different strain backgrounds; although there was strain-to-strain variation, only terbinafine hydrochloride and caspofungin showed consistent, 2-fold differences between white and opaque cells across both strains.