bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genetic background of inflammatory bowel disease: from correlation to causality
Authors: Uniken Venema Werna TC , Voskuil Michiel D , Dijkstra Gerard , Weersma Rinse K , Festen Eleonora AM 
Published: October 2016

AbstractRecent studies have greatly improved our insight into the genetic background of inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale international collaborations have contributed to the identification of 200 independent genetic risk loci for IBD. However, in most of these loci, it is unclear which gene conveys the risk for IBD. More importantly, it is unclear which variant within or near the gene is causal to the disease. Using targeted GWAS, imputation, resequencing of risk loci, and in silico fine‐mapping of densely typed loci, several causal variants have been identified in IBD risk genes, and various pathological pathways have been uncovered. Current research in the field of IBD focuses on the effect of these causal variants on gene expression and protein function. However, more elements than only the genome must be taken into account to disentangle the multifactorial pathology of IBD. The genetic risk loci identified to date only explain a small part of genetic variance in disease risk. Currently, large multi‐omics studies are incorporating factors ranging from the gut microbiome to the environment. In this review, we present the progress that has been made in IBD genetic research and stress the importance of studying causality to increase our understanding of the pathogenesis of IBD. We highlight important causal genetic variants in the candidate genes NOD2, ATG16L1, IRGM, IL23R, CARD9, RNF186, and PRDM1. We describe their downstream effects on protein function and their direct effects on the gut immune system. Furthermore, we discuss the future role of genetics in unravelling disease mechanisms in IBD. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Synthesis of amphiphilic block copolymer consisting of glycopolymer and poly(l‐lactide) and preparation of sugar‐coated polymer aggregates
Authors: Obata Makoto , Otobuchi Ryota , Kuroyanagi Tadao , Takahashi Masaki , Hirohara Shiho 
Published: October 2016

ABSTRACTThe block glycopolymer, poly(2‐(α‐d‐mannopyranosyloxy)ethyl methacrylate)‐b‐poly(l‐lactide) (PManEMA‐b‐PLLA), was synthesized via a coupling approach. PLLA having an ethynyl group was successfully synthesized via ring‐opening polymerization using 2‐propyn‐1‐ol as an initiator. The ethynyl functionality of the resulting polymer was confirmed by MALDI‐TOF mass spectroscopy. In contrast, PManEMA having an azide group was prepared via AGET ATRP using 2‐azidopropyl 2‐bromo‐2‐methylpropanoate as an initiator. The azide functionality of the resulting polymer was confirmed by IR spectroscopy. The Cu(I)‐catalyzed 1,3‐dipolar cycloaddition between PLLA and PManEMA was performed to afford PManEMA‐b‐PLLA. The block structure was confirmed by 1H NMR spectroscopy and size exclusion chromatography. The aggregating properties of the block glycopolymer, PManEMA16k‐b‐PLLA6.4k (Mn,PManEMA = 16,000, Mn,PLLA = 6400) was examined by 1H NMR spectroscopy, fluorometry using pyrene, and dynamic light scattering. The block glycopolymer formed complicated aggregates at concentrations above 21 mg·L−1 in water. The d‐mannose presenting property of the aggregates was also characterized by turbidimetric assay using concanavalin A. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 395–403
Privacy‐preserving multi‐receiver signcryption scheme for heterogeneous systems
Authors: Li Yahong , Wang Caifen , Zhang Yulei , Niu Shufen 
Published: October 2016

AbstractIn recent years, secure communication and privacy‐preserving are gaining popularity because of the advent of wireless network. Certificateless cryptography (CLC) and identity‐based cryptography (IBC) have already been widely applied in the area of wireless network. Hence, to achieve secure communication from CLC to IBC, we present a heterogeneous signcryption scheme that enables a sender in the CLC to transmit a message to multi‐receiver in the IBC. Our scheme has no restrictions on the system parameters and master keys; private key generator and key generating center generate their own system parameters and master key for the IBC users and the CLC user, separately. Considering privacy‐preserving in heterogeneous communication, we show that our scheme can realize the anonymity of all receivers. Compared with other schemes, our scheme has more advantages, such as public verification and decryption fairness, which are attractive for wireless network applications. Moreover, our scheme has the indistinguishability against adaptive chosen ciphertext attacks, the existential unforgeability against adaptive chosen messages attacks, and anonymous indistinguishability of encryptions under selective‐ID, chosen ciphertext attack in the random oracle model. Copyright © 2016 John Wiley & Sons, Ltd.
Ideal social secret sharing using Birkhoff interpolation method
Authors: Eslami Ziba , Pakniat Nasrollah , Nojoumian Mehrdad 
Published: October 2016

AbstractThe concept of social secret sharing was introduced in 2010 by Nojoumian et al. In the scheme of Nojoumian et al. (called SSS), the number of shares allocated to each party depends on the player's reputation and the way he interacts with other parties. In other words, weights of the players are periodically adjusted such that cooperative participants receive more shares compared with non‐cooperative parties. As our contribution, we propose an ideal social secret sharing in which the size of each player's share is equal to the size of the secret. This property will be achieved using hierarchical threshold secret sharing. We show that the proposed scheme is secure in a passive adversary model. Compared with SSS, our proposed scheme is more efficient in terms of the share size, communication complexity, and computational complexity of the “sharing” protocol. However, the “social tuning” and “reconstruction” protocols of SSS are computationally more efficient than those of the proposed scheme. Depending on the number of execution of social tuning protocol, this might be a reasonable compromise because the reconstruction protocol is executed only once throughout the secret's lifetime. Copyright © 2016 John Wiley & Sons, Ltd.
Detecting duplicate bug reports with software engineering domain knowledge
Authors: Aggarwal Karan , Timbers Finbarr , Rutgers Tanner , Hindle Abram , Stroulia Eleni , Greiner Russell 
Published: October 2016

Bug deduplication, ie, recognizing bug reports that refer to the same problem, is a challenging task in the software‐engineering life cycle. Researchers have proposed several methods primarily relying on information‐retrieval techniques. Our work motivated by the intuition that domain knowledge can provide the relevant context to enhance effectiveness, attempts to improve the use of information retrieval by augmenting with software‐engineering knowledge. In our previous work, we proposed the software‐literature‐context method for using software‐engineering literature as a source of contextual information to detect duplicates. If bug reports relate to similar subjects, they have a better chance of being duplicates. Our method, being largely automated, has a potential to substantially decrease the level of manual effort involved in conventional techniques with a minor trade‐off in accuracy.In this study, we extend our work by demonstrating that domain‐specific features can be applied across projects than project‐specific features demonstrated previously while still maintaining performance. We also introduce a hierarchy‐of‐context to capture the software‐engineering knowledge in the realms of contextual space to produce performance gains. We also highlight the importance of domain‐specific contextual features through cross‐domain contexts: adding context improved accuracy; Kappa scores improved by at least 3.8% to 10.8% per project.
The Subjective Experience of Patients Diagnosed with Hereditary Hemorrhagic Telangiectasia: a Qualitative Study
Authors: Geerts Laura , Fantini‐Hauwel Carole , Brugallé Elodie , Boute Odile , Frénois Frédéric , Defrance Lydie , Manouvrier‐Hanu Sylvie , Petit Florence , Antoine Pascal 
Published: October 2016

AbstractThe aim of the present study was to understand the context and psychological impact for patients diagnosed with hereditary hemorrhagic telangiectasia (HHT). Semi‐structured interviews were conducted with 9 patients affected by HHT, and the transcripts were analyzed using interpretative phenomenological analysis. The results of this study allowed us to propose a new hypothesis to explain the delay in diagnosis: the trivialization of symptoms associated with HHT. Moreover, the results showed that a genetic diagnosis of HHT results in emotional shock, uncertainty about the future, and worry about one's children in parents who are confronted with the dilemma of facing the reality of the diagnosis or delaying dealing with the diagnosis until disease onset. Family and personal perceptions of the disease influenced not only the delay in diagnosis but also the emotional and behavioral reactions of patients following a genetic diagnosis.
Evaluation of non-response in quality control of nasal septal surgery
Authors: Egeland M T , Tarangen M , Gay C , Døsen L K , Haye R 
Published: October 2016

AbstractObjective:Questionnaires are often used to assess the results of nasal septoplasty, but response rates vary widely. The possible bias caused by non-responders was evaluated to determine the validity of questionnaire results.Methods:Post-operative questionnaires employing visual analogue scales for nasal obstruction were mailed to 182 patients. The 62 non-responders (34.1 per cent) were contacted by telephone, 58 (93.5 per cent) of whom were contactable and responded orally to the questionnaire.Results:Non-responders were younger, but no different from responders with regard to gender, smoking habits or allergies. Post-operative visual analogue scale obstruction scores were slightly, but not statistically, higher in non-responders. However, because non-responders’ pre-operative scores were lower, obstruction scores improved less than in responders. The main reason for not responding was forgetfulness. Some would have preferred an electronic version of the questionnaire.Conclusion:Although post-operative obstruction scores did not differ between the groups, nasal obstruction scores improved more among responders than non-responders. Thus, low response rates may cause bias.
Foreign language anxiety levels in Second Life oral interaction
Authors: Melchor-Couto Sabela 
Published: October 2016

AbstractVirtual worlds have been described as low anxiety environments (Dickey, 2005), where students may feel “shielded” behind their avatars (Rosell-Aguilar, 2005: 432). The aim of this article is to analyse the evolution of the Foreign Language Anxiety (FLA) levels experienced by a group of participants who used the virtual worldSecond Lifefor oral interaction (VW Group). The data gathered was compared to that of a group of students who completed similar oral interaction activities in the traditional classroom (CR Group). The quantitative and qualitative data analysed indicates that the FLA levels of the VW Group decreased as weeks went by and that they were lower than those experienced by the CR Group. The anonymity afforded by the VW had a positive effect on some of the students, who reported increased self-confidence and decreased nervousness. However, the students’ comments suggest that this anonymity may wear off once they feel they know their interlocutor. Anonymity may not be the only reason to explain the decrease in FLA.
In or out? Poverty dynamics among older individuals in the UK
Authors: KANABAR RICKY 
Published: October 2016

AbstractUsing the largest household panel surveyUnderstanding Society, this paper investigates low-income dynamics among pensioner households in the UK controlling for biases due to initial conditions and non-random survey attrition. Estimation results indicate there is a correlation between initial and conditional poverty status, specifically, there is regression towards the mean. The results find no evidence of a correlation between initial poverty status, conditional poverty status and survey attrition. The findings show the importance of benefit income in determining poverty status, suggesting that a dichotomous measure such as poverty status may not suitably reflect actual pensioner living standards. Aside from benefit income, receipt of employer and occupational pension, health, education and subjective financial situation are important in determining initial and conditional poverty status. Stylised examples highlight the significant differences in the ‘poverty experience’ which arise due to differences individual and household characteristics.
Period Ratio Distribution of Near-Resonant Planets Indicates Planetesimal Scattering
Authors: Chatterjee Sourav , Krantzler Seth O. , Ford Eric B. 
Published: October 2016

AbstractAn intriguing trend among itKepler's multi-planet systems is an overabundance of planet pairs with period ratios just wide of mean motion resonances (MMR) and a dearth of systems just narrow of them. In a recently published paper Chatterjee & Ford (2015; henceforth CF15) has proposed that gas-disk migration traps planets in a MMR. After gas dispersal, orbits of these trapped planets are altered through interaction with a residual planetesimal disk. They found that for massive enough disks planet-planetesimal disk interactions can break resonances and naturally create moderate to large positive offsets from the initial period ratio for large ranges of planetesimal disk and planet properties. Divergence from resonance only happens if the mass of planetesimals that interact with the planets is at least a few percent of the total planet mass. This threshold, above which resonances are broken and the offset from resonances can grow, naturally explains why the asymmetric large offsets were not seen in more massive planet pairs found via past radial velocity surveys. In this article we will highlight some of the key findings of CF15. In addition, we report preliminary results from an extension of this study, that investigates the effects of planet-planetesimal disk interactions on initially non-resonant planet pairs. We find that planetesimal scattering typically increases period ratios of non-resonant planets. If the initial period ratios are below and in proximity of a resonance, under certain conditions, this increment in period ratios can create a deficit of systems with period ratios just below the exact integer corresponding to the MMR and an excess just above. From an initially uniform distribution of period ratios just below a 2:1 MMR, planetesimal interactions can create an asymmetric distribution across this MMR similar to what is observed for thekeplerplanet pairs.
Spin-orbit alignment of exoplanet systems: how can Asteroseismology help us?
Authors: Campante Tiago L. 
Published: October 2016

AbstractMeasuring the obliquities of exoplanet-host stars provides invaluable diagnostic information for theories of planetary formation and migration. Most of these results have so far been obtained by measuring the Rossiter--McLaughlin effect, clearly favoring systems that harbor hot Jupiters. While it would be extremely helpful to extend these measurements to long-period and multiple-planet systems, it is also true that the latter systems tend to involve smaller planets, making it ever so difficult to apply such techniques. Asteroseismology provides a powerful method of determining the inclination of the stellar spin axis from an analysis of the rotationally-induced splittings of the oscillation modes. This provides an estimate of the obliquity independently of other methods. The applicability of the asteroseismic method is determined by the stellar properties and not by the signal-to-noise ratio of the transit data. Here we present a recap of the spin-orbit geometry, explain how the asteroseismic method works, and review previous applications of the method to exoplanet-host stars.
The IAU's involvement in the Astronomy and World Heritage Initiative: achievements and challenges
Authors: Ruggles Clive 
Published: October 2016

AbstractSince 2008 the IAU has worked with UNESCO and its advisory bodies to help recognise, promote and protect all types of astronomical heritage and to encourage nominations for World Heritage Sites relating to astronomy. I review the main challenges and achievements so far, and indicate how the Astronomy and World Heritage Initiative is likely to develop in the future.
What makes astronomical heritage valuable? Identifying potential Outstanding Universal Value in cultural properties relating to astronomy
Authors: Cotte Michel 
Published: October 2016

AbstractThis communication presents the situation regarding astronomical and archaeoastronomical heritage related to the World Heritage Convention through recent years up until today. Some parallel events and works were promoted strongly within the IAU–UNESCO Initiative during the International Year of Astronomy (2009). This was followed by a joint program by the IAU and ICOMOS—an official advisory body assisting the World Heritage Committee in the evaluation of nomination dossiers. The result of that work is an important publication by around 40 authors from 20 different countries all around the world: Heritage Sites of Astronomy and Archaeoastronomy in the Context of the UNESCO World Heritage Convention (Ruggles & Cotte 2010). A second volume is under preparation (2015). It was also accompanied by some initiatives such as the “Windows to the Universe" organisation and the parallel constitution of local “Starlight Reserves”. Some regional meetings studying specific facets or regional heritage in the field giving significant knowledge progresses also accompanied the global trend for astronomical heritage.WH assessment is defined by a relatively strict format and methodology. A key phrase is “demonstration of Outstanding Universal Value” to justify the WH Listing by the Committee. This communication first examines the requirements and evaluation practices about of demonstrating OUV for a given place in the context of astronomical or archaeoastronomical heritage. That means the examination of the tangible attributes, an inventory of the property in terms of immoveable and moveable components and an inventory of intangible issues related to the history (history of the place in the context of the history of astronomy and cultural history). This is also related to the application to the site of the concept of integrity and authenticity, as regards the place itself and in comparison with other similar places (WH sites already listed, sites on national WH Tentative Lists, or other similar places in the region). The second issue of the communication is to give a glimpse of today's WH List, including some difficulties with listing and occasional failures, and trends and promising approaches.
Twentieth-century astronomical heritage: the case of the Brazilian National Observatory
Authors: Barboza Christina Helena 
Published: October 2016

AbstractThis paper aims at contributing to the UNESCO-IAU Astronomy and World Heritage Initiative's discussions by presenting the case study of a 20th-century observatory located in a South American country. In fact, the National Observatory of Brazil was created in the beginning of the 19th century, but its present facilities were inaugurated in 1921. Through this paper a brief description of the heritage associated with the Brazilian observatory is given, focused on its main historical instruments and the scientific and social roles it performed along its history. By way of conclusion, the paper suggests that the creation of the Museum of Astronomy and Related Sciences with its multidisciplinary team of academic specialists and technicians was decisive for the preservation of that expressive astronomical heritage.
Canada's Dominion Astrophysical Observatory and the rise of 20th Century Astrophysics and Technology
Authors: Hesser James E. , Bohlender David , Crabtree Dennis 
Published: October 2016

AbstractConstruction of Canada's Dominion Astrophysical Observatory (DAO) commenced in 1914 with first light on 6 May 1918. As distinct from the contemporaneous development with private funding of major observatories in the western United States, DAO was (and remains) funded by the federal government. Canada's initial foray into ‘big science’, creation of DAO during the First World War was driven by Canada's desire to contribute significantly to the international rise of observational astrophysics enabled by photographic spectroscopy. In 2009 the Observatory was designated a National Historic Site. DAO's varied, rich contributions to the astronomical heritage of the 20th century continue in the 21st century, with particularly strong ties to Maunakea.
Dealing with activity in RV planet searches
Authors: Boisse Isabelle 
Published: October 2016

AbstractPrecise radial velocity measurements of a star allow to search for planets. But this method has to face with irregularly time series. Stellar variabilities: pulsation, granulation, stellar activity on a short and long timescale, also modify the measure of the radial velocities. There is indeed a growing literature of controversies on how a signal is interpreted as a planet or due to stellar activity. I present how the star variations change the measured RVs, which techniques and indices are used by several teams to disentangle activity and planets, and the future options that are being studied.
Estimations of uncertainties of frequencies
Authors: Eyer Laurent , Nicoletti Jean-Marc , Morgenthaler Stephan 
Published: October 2016

AbstractDiverse variable phenomena in the Universe are periodic. Astonishingly many of the periodic signals present in stars have timescales coinciding with human ones (from minutes to years). The periods of signals often have to be deduced from time series which are irregularly sampled and sparse, furthermore correlations between the brightness measurements and their estimated uncertainties are common. The uncertainty on the frequency estimation is reviewed. We explore the astronomical and statistical literature, in both cases of regular and irregular samplings. The frequency uncertainty is depending on signal to noise ratio, the frequency, the observational timespan. The shape of the light curve should also intervene, since sharp features such as exoplanet transits, stellar eclipses, raising branches of pulsation stars give stringent constraints. We propose several procedures (parametric and nonparametric) to estimate the uncertainty on the frequency which are subsequently tested against simulated data to assess their performances.