bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Technique for Sampling of Breast Implant–associated Seroma in Anaplastic Large Cell Lymphoma
Authors: van Dorp Martijn , T’Kindt Johan , Mertens Marianne , Colpaert Steven D. M. 
Published: April 2016

Summary:
We describe a novel technique for the sampling of breast implant–associated seroma. Using a blunt-tip lipofilling cannula, we have the freedom of movement to sample all fluid collections and prevent the misfortunes of damaging the implant. Also, we have demonstrated the inability of the Coleman style I lipofilling cannula to perforate a silicone breast implant. This practical and reliable technique will prove to be useful in managing the breast implant–associated seroma, especially with the rising incidence of the anaplastic large cell lymphoma, where the sampling of seroma is mandatory.
Use of Short Messaging Service for Hypertension Management
Authors: Vargas Grecia , Cajita Maan Isabella , Whitehouse Erin , Han Hae-Ra 
Published: April 2016

Background:
Mobile phone Short Message Service (SMS) is a tool now used by the health research community, providing the capability for instant communication between patients and health professionals. Greater understanding of how to best use SMS as a means to improve healthcare delivery and outcomes will foster innovation in research and provide an opportunity to progress as a public health community.

Purpose:
The purposes of this systematic review are 2-fold: (1) to provide insight on the most used mobile phone SMS practices and characteristics in hypertension (HTN) outcome-focused publications and (2) to critically evaluate empirical evidence associated with SMS utilization and BP outcomes.

Methods:
Two independent systematic literature searches were completed. The final selected studies each then underwent data extraction and quality-rating assessment, followed by an evaluation for a meta-analysis to measure mean difference of the change in BP.

Results:
A total of 6 studies meeting the inclusion criteria were included in the review. Feasibility assessment for a meta-analysis was found unfavorable because of the variation among studies. Short Message Service interventions focused on BP management were most effective in studies featuring 2-way communication and individual patient-tailored content, and guided by evidence-based HTN management practices.

Implications:
Short Message Service interventions for HTN management were supported through evidence provided by the studies reviewed. Short Message Service holds strong potential to bring greater innovation to HTN management and care, especially in racial/ethnic minority populations that face psychosocial and structural barriers in healthcare access and utilization.
Knowledge of Implantable Cardioverter Defibrillator Purpose and Function Among Nurses in the United States
Authors: Steffes Susanne S. , Thompson Elaine A. , Bridges Elizabeth M. , Dougherty Cynthia M. 
Published: April 2016

Background:Nurses play a crucial role in patient education and adaptation to having an implantable cardioverter defibrillator (ICD).Objective:The aim of this study was to assess cardiology nurses’ knowledge and confidence in providing education and support to ICD recipients.Methods:A cross-sectional descriptive survey was used to assess nurses’ knowledge and experience caring for ICD recipients in 2 academic medical centers in the Pacific Northwest, using an instrument developed in 2004 in the United Kingdom.Results:Nurses (N = 74) worked on cardiology units or clinics, primarily held a baccalaureate degree or higher (85%), and had 16 years or more of nursing experience and 6 to 10 years of cardiology experience. The overall average knowledge score was 77%, with knowledge about modern ICD technology averaging 55%. Nurses’ confidence, using 10-point scale, in preparing patients to receive an ICD implant was 6.32 ± 2.56, for preparing patients for discharge was 6.14 ± 2.43, and for providing education about ICD shocks was 6.63 ± 2.50. Nurses were most knowledgeable about factors that affect patient retention of knowledge and ICD-related environmental hazards. Nurses lacked knowledge about the basic ICD components, purpose of cardiac resynchronization, and dual-chamber ICDs. Factors associated with higher knowledge scores included past experience caring for a patient with an ICD and working in an electrophysiology outpatient clinic.Conclusions:The ICD knowledge of US nurses in 2015 was similar to that reported in the United Kingdom in 2004, with limited knowledge about the complexities of modern ICD devices. Such deficits in knowledge may affect the quality of education provided to ICD recipients in preparing them to live safely with an ICD.
Understanding Self-regulation Behaviors in South Asians With Coronary Artery Disease
Authors: Jiwani Rozmin B. , Cleveland Lisa M. , Patel Darpan I. , Virani Salim S. , Gill Sara L. 
Published: April 2016

Background:
South Asians (SAs) have a well-documented risk for mortality related to coronary artery disease (CAD). However, there is a lack of evidence to guide the implementation and dissemination of primary and secondary interventions to control and deter progression of CAD in SAs.

Objective:
The aim of this study is to explore and describe self-regulation behaviors in SAs with CAD using Leventhal’s Common Sense Model.

Methods:
In this mixed-methods study, quantitative data were collected using 3 survey questionnaires (demographics, Illness Perception Questionnaire–Revised, and Coping/Self-Regulation Behaviors). Before completing the surveys, a subset of the sample (n = 20) participated in individual face-to-face or telephone interviews.

Results:
A total of 102 SAs were enrolled (age, 53.5 ± 9.98 years). On average, participants rated themselves high (63 ± 3.06) on negative perceptions. In addition, they discussed desi diet, stress, a lack of physical activity, ignoring symptoms, and kismet (fate) as the most important perceived causes of their CAD. Most of the participants modified their lifestyle after their CAD event. Participants expressed regret for not having changed their lifestyle earlier when they were experiencing early symptoms of their CAD.

Conclusion:
Findings from this study enhance the understanding of self-regulation behaviors of SAs with CAD. Ultimately, these findings will inform the development and implementation of targeted interventions that address culture-specific lifestyle modification for SAs with CAD.
Long-term Physical Activity Behavior After Completion of Traditional Versus Fast-track Cardiac Rehabilitation
Authors: Ramadi Ailar , Buijs David M. , Threlfall Tyler G. , Aggarwal Sandeep G. , Arena Ross , Rodgers Wendy M. , Haennel Robert G. 
Published: April 2016

Background:Despite the health benefits associated with regular physical activity (PA), many cardiac patients fail to maintain optimal levels of PA after completing cardiac rehabilitation (CR). The long-term impact of different CR delivery models on the PA habits of cardiac patients is not completely understood.Objective:The purpose of this study is to use a multisensor accelerometer to compare the long-term impact of a traditional versus fast-track CR on the PA of patients with coronary artery disease 6 months after CR entry.Methods:Forty-four participants attended either traditional (twice a week, 12 weeks; n = 24) or fast-track (once a week, 8 weeks; n = 20) CR. Exercise capacity (ie, 6-minute walk test distance) and PA were assessed at baseline and at 12 weeks and 6 months after CR entry.Results:At 12 weeks, exercise capacity increased significantly in both groups and remained elevated by the 6-month follow-up. Sedentary time decreased from baseline to 12 weeks. However, at 6 months, it was comparable with the baseline level. There was no significant change in any other PA marker (ie, steps/day, time in light and moderate-vigorous PA) over the course of the study.Conclusions:Findings support the long-term effectiveness of CR on exercise capacity irrespective of the delivery model. However, participation in CR program, whether it be a traditional or fast-track CR exercise program, may not lead to long-term PA behavior change. Thus, CR participants may benefit from structured strategies that promote long-term PA adherence in addition to facilitating exercise capacity improvement.
The Growing Integration of Physician Practices
Authors: Richards Michael R. , Nikpay Sayeh S. , Graves John A. 
Published: April 2016

Background:
Strategic alignment and integration is currently in vogue throughout the health care industry, but its diffusion and pace have not been documented in recent years. The full range of downstream implications from greater alignment between hospitals and physicians has also not been completely explored.

Objectives:
We track the organizational landscape among all office-based US physician practices from 2009 to 2015 and document the degree of vertical integration over time. Then, we examine the implications of vertical integration on practices’ acceptance of publicly insured patients.

Research Design:
We use descriptive trends and linear regression models with practice level fixed effects to capture the relationships between within-office changes in integration behavior and changes in public payer acceptance.

Results:
Independent (nonintegrated) physician practices are still the most common organizational type, but their share is declining as the share of practices integrated with a health system increases 3-fold between 2009 and 2015. Although >80% of practices that are part of a health system accept Medicaid, <60% of independent practices will see these patients. Vertically integrating with a health system makes it more likely a practice will start seeing Medicaid patients.

Conclusions:
Integration—and possibly consolidation—appears to be occurring and may be increasing over time in the United States. However, it also seems to increase the number of physician practices participating in the Medicaid program. This beneficial side effect has not been previously documented and should be kept in mind as policymakers weigh the pros and cons of a more integrated health care system.
A Narrative Review of Patient and Family Engagement
Authors: Cené Crystal W. , Johnson Beverley H. , Wells Nora , Baker Beverly , Davis Renee , Turchi Renee 
Published: April 2016

Background:
Patient and family engagement (PFE) is vital to the spirit of the medical home. This article reflects the efforts of an expert consensus panel, the Patient and Family Engagement Workgroup, as part of the Society of General Internal Medicine’s 2013 Research Conference.

Objective:
To review extant literature on PFE in pediatric and adult medicine and quality improvement, highlight emerging best practices and models, suggest questions for future research, and provide references to tools and resources to facilitate implementation of PFE strategies.

Methods:
We conducted a narrative review of relevant articles published from 2000 to 2015. Additional information was retrieved from personal contact with experts and recommended sources from workgroup members.

Results:
Despite the theoretical importance of PFE and policy recommendations that PFE occurs at all levels across the health care system, evidence of effectiveness is limited, particularly for quality improvement. There is some evidence that PFE is effective, mostly related to engagement in the care of individual patients, but the evidence is mixed and few studies have assessed the effect of PFE on health outcomes. Measurement issues and the lack of a single comprehensive conceptual model pose challenges to progress in this field. Recommendations for future research and a list of practical tools and resources to facilitate PFE are provided.

Conclusions:
Although PFE appeals to patients, families, providers, and policy-makers, research is needed to assess outcomes beyond satisfaction, address implementation barriers, and support engagement in practice redesign and quality improvement. Partnering with patients and families has great potential to support high-quality health care and optimize outcomes.
Delays in Seeking Health Care: Comparison of Veterans and the General Population
Authors: Lee Doohee , Begley Charles E. 
Published: April 2016

Objectives:Recent reports of delays in receiving care among U.S. Veterans have received national attention. Such delays may have an effect on veterans' propensity to seek healthcare as well, which could be detrimental to their health. There exists no evidence at the national level of the magnitude of perceived care delay in the Veterans Affairs (VA) system and how it compares to populations with other types of insurance coverage in the U.S.Study Design and Methods:This cross-sectional study analyzed a recent nationally representative survey database (n = 10,907). Descriptive and multivariate regression analyses were performed to determine how care delay for veterans compares with the general population.Results:We found that 17.2% of Americans delayed seeking needed healthcare in 2010-2011, but the figure was 29% for veterans. Also, there was a significant association of care delay with VA health care coverage after adjusting for other personal factors and region of the country.Conclusions:Study results suggest a possible link between VA access problems and veterans' behavior in seeking needed healthcare, which may be creating disparities in the effectiveness of care for this vulnerable and deserving population. Our study provides evidence of self-reported care delay among veterans. More studies are necessary to further understand factors in relation to delaying seeking care among veterans.
Sonoelastography in the Evaluation of Plantar Fasciitis Treatment
Authors: Kim Minchul , Choi Yun Sun , You Myung-Won , Kim Jin Su , Young Ki Won 
Published: April 2016

Objective
The aim of this study was to investigate whether ultrasound elastography can demonstrate the outcome of the treatment in comparison with gray-scale imaging.

Methods
Sixteen patients (mean age, 46.9 years) with plantar fasciitis were prospectively enrolled after unsuccessful conservative treatment. Individuals graded their heel pain on a 100-mm visual analogue scale (VAS) and underwent gray-scale ultrasonography and sonoelastography. Collagen was injected in the heels. Fascial thickness and hypoechogenicity, perifascial edema, and plantar fascial elasticity were evaluated. Follow-up sonoelastography and VAS grading were done 3 months after the injection. Statistical analyses were performed by the paired t test and the Fisher exact test. A P < 0.05 was considered statistically significant.

Results
Mean plantar fascial thickness showed insignificant decrease on follow-up (from 4.30 [1.37] to 4.23 [1.15] mm, P = 0.662). Fascial hypoechogenicity and perifascial edema did not change significantly after treatment. The mean strain ratio of the plantar fascia was significantly increased (from 0.71 [0.24] to 1.66 [0.72], P = 0.001). Softening of the plantar fascia decreased significantly after injection (from 12 to 3 ft, P = 0.004). Twelve (75%) of 16 patients showed significant VAS improvement at the follow-up.

Conclusions
Sonoelastography revealed a hardening of the plantar fascia after collagen injection treatment and could aid in monitoring the improvement of the symptoms of plantar fasciitis, in cases where gray-scale imaging is inconclusive.
Diagnostic Yield of Fine-Needle Aspiration for Axillary Lymph Nodes During Screening Breast Ultrasound
Authors: Youn Inyoung , Kim Eun-Kyung , Yoon Jung Hyun , Moon Hee Jung , Kim Min Jung 
Published: April 2016

Abstract
The purpose of our study was to assess the positive predictive value (PPV) of ultrasound (US)-guided fine-needle aspiration (FNA) and the cancer detection rate for incidentally detected abnormal axillary lymph node (LN) in patients who underwent screening US. We retrospectively reviewed 72 LNs of 69 patients (mean age, 44.9 years) who underwent US-FNA for incidentally detected abnormal axillary LNs on 50,488 screening US from January 2005 to December 2011. The PPV of US-FNA and the cancer detection rate were calculated. We evaluated US images for lymph node size, abnormal findings (hilum loss, eccentric cortical thickening, round shape, extranodal extension, or marked hypoechoic cortex), and mammography for the identification of abnormal LNs. The PPV of each finding was also calculated. The PPV of US-FNA and the cancer detection rate were 2.8% (2/72) and 0.004% (2/50,488), respectively. The mean (SD) measurements for long-axis, short-axis, and cortical thickening of the LNs were 14.9 (5.9) mm, 8.5 (3.5) mm, and 5.8 (2.8) mm, respectively. Of the positive LNs, US findings of hilum loss, eccentric cortical thickening, and extranodal extension were found, and each corresponding PPV was 6.3% (1/16), 1.8% (1/56), and 14.3% (1/7), respectively. The PPV of mammography was 14.3% (1/7). Our results suggest that the PPVs of US-FNA and the cancer detection rate for incidentally detected abnormal axillary LNs during screening US are too low to recommend axillary US during breast US screening and that follow-up is acceptable for abnormal LNs detected during screening breast US that do not have extranodal extension or are negative on mammography.
Torsed Ovarian Dermoid
Authors: Watson Abby , Winter Thomas 
Published: April 2016

Abstract
Ovarian dermoids constitute the most common ovarian neoplasm and make up approximately 20% of all ovarian neoplasms. Dermoids are most common in the reproductive age group, but unlike other ovarian germ cell tumors, their age distribution is quite broad. Torsion may occur in approximately 15% of cases and is more common during pregnancy and in the 6 weeks immediately after delivery. We present a 17-year-old who came to the emergency department in her puerperium with severe right lower quadrant pain. The diagnosis of a 12-cm dermoid was missed at ultrasound. We discuss the reasons for the mistake on ultrasound and give strategies to prevent this from happening in the future. Three commonly overlooked teaching points regarding dermoids are discussed. Ultrasound and computed tomographic imaging, operative course, and correlative intraoperative and pathological images are presented.
From what we perceive to what we remember: Characterizing representational dynamics of visual memorability
Authors: Khaligh-Razavi Seyed-Mahdi , Bainbridge Wilma A. , Pantazis Dimitrios , Oliva Aude 
Published: April 2016

AbstractNot all visual memories are equal—some endure in our minds, while others quickly disappear. Recent behavioral work shows we can reliably predict which images will be remembered. This image property is calledmemorability. Memorability is intrinsic to an image, robust across observers, and unexplainable by low-level visual features. However, its neural bases and relation with perception and memory remain unknown. Here we characterize the representational dynamics of memorability using magnetoencephalography (MEG). We find memorability is indexed by brain responses starting at 218ms for faces and 371ms for scenes—later than classical early face/scene discrimination perceptual signals, yet earlier than the late memory encoding signal observed at ~700ms. The results show memorability is a high-level image property whose spatio-temporal neural dynamics are different from those of memory encoding. Together, this work brings new insights into the underlying neural processes of the transformation from what we perceive to what we remember.
HDAC inhibition protects degenerating cone photoreceptorsin vivo
Authors: Trifunović Dragana , Arango-Gonzalez Blanca , Comitato Antonella , Barth Melanie , Sahaboglu Ayse , del Amo Eva M. , Kulkarni Manoj , Hauck Stefanie M. , Ueffing Marius , Urtti Arto , Arsenijevic Yvan , Marigo Valeria , Paquet-Durand François 
Published: April 2016

AbstractRetinal diseases caused by cone photoreceptor cell death are devastating as the patients are experiencing loss of accurate and color vision. Understanding the mechanisms of cone cell death and the identification of key players therein could provide new treatment options. We studied the neuroprotective effects of a histone deacetylase inhibitor, Trichostatin A (TSA), in a mouse model of inherited, primary cone degeneration (cpfl1). We show that HDAC inhibition protects conesin vitro, in retinal explant cultures. More importantly,in vivoa single TSA injection increased cone survival for up to 10 days post-injection. In addition, the abnormal, incomplete cone migration pattern in thecpfl1retina was significantly improved by HDAC inhibition. These findings suggest a crucial role for HDAC activity in primary cone degeneration and highlight a new avenue for future therapy developments for cone dystrophies and diseases associated with impaired cone migration.
ThePseudomonas aeruginosaPSL polysaccharide is a social but non-cheatable trait in biofilms
Authors: Irie Yasuhiko , Roberts Aled E. L. , Kragh Kasper N. , Gordon Vernita D. , Hutchison Jaime , Allen Rosalind J. , Melaugh Gavin , Bjarnsholt Thomas , West Stuart A. , Diggle Stephen P. 
Published: April 2016

ABSTRACTExtracellular polysaccharides are compounds secreted by microorganisms into the surrounding environment and which are important for surface attachment and maintaining structural integrity within biofilms. The social nature of many extracellular polysaccharides remains unclear, and it has been suggested that they could function as either co-operative public goods, or as traits that provide a competitive advantage. Here we empirically test the co-operative nature of the PSL polysaccharide, which is crucial for the formation of biofilms inPseudomonas aeruginosa. We show that: (1) PSL is not metabolically costly to produce; (2) PSL provides population level benefits in biofilms, for both growth and antibiotic tolerance; (3) the benefits of PSL production are social and are shared with other cells; (4) the benefits of PSL production appear to be preferentially directed towards cells which produce PSL; (5) cells which do not produce PSL are unable to successfully exploit cells which produce PSL. Taken together, this suggests that PSL is a social but relatively non-exploitable trait, and that growth within biofilms selects for PSL-producing strains, even when multiple strains can interact (low relatedness).
Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients
Authors: Jaeger Philipp A. , Stan Trisha M. , Czirr Eva , Britschgi Markus , Berdnik Daniela , Huang Ruo-Pan , Boeve Bradley F. , Boxer Adam L. , Finch NiCole , Fragiadakis Gabriela K. , Graff-Radford Neill R. , Huang Ruochun , Johns Hudson , Karydas Anna , Knopman David S. , Leipold Michael , Maecker Holden , Miller Zachary , Petersen Ronald C. , Rademakers Rosa , Sun Chung-Huan , Younkin Steve , Miller Bruce L. , Wyss-Coray Tony 
Published: April 2016

ABSTRACTThe growing link between systemic environment and brain function opens the possibility that cellular communication and composition in blood are correlated with brain health. We tested this concept in frontotemporal dementia with novel, unbiased tools that measure hundreds of soluble signaling proteins or characterize the vast immune cell repertoire in blood. With these tools we discovered complementary abnormalities indicative of abnormal T cell populations and autoimmunity in frontotemporal dementia.