bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managerial ability and firm growth: intellectual capital components
Authors: Kweh Qian Long , Ting Irene Wei Kiong , Asif Jawad , Lu Wen-Min 
Published: October 2024

PurposeThis study analyses the way various components of intellectual capital (IC), namely, human capital (HC), structural capital (SC), relational capital (RC) and innovation capital (INNC), act as mediators in the relationship between managerial ability (MA) and a firm’s ability to achieve growth.Design/methodology/approachThis study employs data envelopment analysis to quantify the MA of 825 Taiwanese listed electronics companies from 2017 to 2022. The proxies of firm growth are return on asset growth, operating income growth and total asset growth. This study then utilises a three-step mediation analysis methodology to examine the relationships between MA, IC and firm growth.FindingsFindings indicate that HC, SC, RC and INNC mediate the link between MA and firm growth. This suggests that competent managers can capitalise on the potential benefits of these investments to achieve firm growth.Practical implicationsCompetent managers can utilise different IC investments to grow the financial performance and strength of their businesses. Managers should continually scan, secure opportunities and adjust their investments in knowledge assets in accordance with the dynamic capabilities view. That is, managers, in general, and operations managers, in particular, can implement guidelines that prioritise IC investments in the future to expedite firms’ development.Originality/valueThis study extends the existing frameworks that study investment variables as mediators between MA and firm outcomes. Most particularly, this study adopts four components of IC for measurement. Moreover, firm performance is measured using dynamic growth indicators rather than static measures.
Social entrepreneurship and value creation in the cultural sector. An empirical analysis using the multidimensional controlling model
Authors: Iodice Gesualda , Bifulco Francesco 
Published: October 2024

Purpose
Social entrepreneurship plays a crucial role in the contemporary economic and social ecosystem, defining a value proposition that incorporates a plurality of dimensions to be considered. This research work analyzes the externalities of social enterprises driven by arts and culture for the territories they operate in.

Design/methodology/approach
A mixed-method approach of a single case study is performed to consider multiple dimensions in the development of controlling models in the managerial field. The framework adopted is then implemented through a longitudinal analysis over the last three years.

Findings
The empirical evidence shows the evolution of the economic and financial performance, the social effectiveness and the institutional legitimacy of the case, explaining the role played in the reference community, even during crisis time. The predictive power of performance changes emerges as a direct link to socially responsible indexes that amplify the attractiveness of value proposition processes.

Research limitations/implications
The results obtained are aligned with Betzlet et al. (2021) key predictor of the success of social entrepreneurship. A wide sample with multiple social enterprises operating in the cultural and creative field needs to be considered in the future, to further advance the literature through a comparative analysis.

Originality/value
This paper reveals that, in the cultural and creative sector, social entrepreneurship value creation is intrinsically linked to the individual and collective identity dimension able to promote cohesion and community well-being.
The potential of virtual reality meetings in international research projects for greenhouse gas emission mitigation
Authors: van Thienen Peter , Tsiami Lydia , Torello Mollie , Savić Dragan 
Published: October 2024

PurposeEuropean Union (EU) research projects generally involve international teams based in different countries. This means that researchers need to travel internationally to participate for in-person meetings, which are crucial for facilitating collaboration among research teams and provide a platform for teams to share their progress. Unfortunately, much of the international traveling in EU projects is done by air and therefore it has a significant carbon footprint. One potential solution that has gained attention in recent years is virtual reality (VR) and the metaverse. The aim of this work is to investigate to what degree VR meetings provide a viable alternative to physical meetings in the context of EU research projects and can thus contribute to climate change mitigation.Design/methodology/approachA three-stepped approach was chosen. First, the requirements for VR meetings were determined by collecting all relevant aspects of physical meetings through a questionnaire. Second, a set of VR meeting experiments were designed and executed. Third, carbon footprints for both physical traveling and VR meetings (lifecycle) were calculated.FindingsWe conclude that VR can be a powerful tool which can supplement international projects and mitigate carbon emissions associated with traveling for in-person meetings by an estimated 7–19 times.Originality/valueThis paper explores the suitability of the current generation of VR technology and quantitatively evaluates its effectiveness for greenhouse gas emissions mitigation in the context of a European research project.
State‐level trends in access to Medicaid family planning services, 2008–2023
Authors: Williams Austin M. , Saldarriaga Enrique M. , Cramer Ryan 
Published: October 2024

AbstractObjectiveTo characterize the landscape of policies that determine eligibility for family planning services through Medicaid programs and describe trends in eligibility and its determinants over time.Data Sources and Study SettingSecondary data were collected for all states in the United States for the years 2008 through 2023. Data on economic and demographic characteristics came from the American Community Survey (ACS).Study DesignOur descriptive study characterized state adoptions of Medicaid family planning section 1115 waivers and state plan amendments (SPA) and their eligibility criteria. We then estimated the proportion of women aged 19–44 years who were eligible for family planning services through Medicaid and identified the key determinants of changes in eligibility, by state and year.Data Collection/Extraction MethodsInformation on state Medicaid policies was extracted from documentation on the Centers for Medicare & Medicaid Services website. When estimating the eligible population sizes, the denominator was women aged 19–44 years, the group most likely to be eligible for Medicaid family planning programs. Supplemental data on program enrollment or utilization were collected from states' websites and reports.Principal FindingsThough eligibility limits for family planning through Medicaid generally increased over time, the proportion of women aged 19–44 years eligible for at least limited benefits decreased from 45.0% in 2012 to 39.4% in 2022, largely because of increases in household income. Trends varied considerably across states and by eligibility pathway. Among women with incomes below the poverty level, the proportion who were not eligible for Medicaid family planning services decreased from 6.3% in 2013 to 1.5% in 2022.ConclusionsOur data demonstrated substantial geographic and temporal variation in eligibility for family planning services through Medicaid. We identified key drivers of eligibility changes that may have important implications for health services analyses of means‐tested public programs.
Frequency and clinical implications of findings on true whole‐body 18F‐FDG PET in the assessment of breast cancer
Authors: Cheng Chris‐Tin , Lee Shane , Ahmad Kabir , Ma Dickson 
Published: October 2024

AbstractIntroductionIn the assessment of breast cancer using 18‐F FDG PET/CT, the incremental clinical benefit in performing a true whole‐body PET/CT (with a field of view (FOV) from the vertex to the toes) over a limited whole‐body PET/CT (with a FOV from the base of skull to the mid‐thighs) is uncertain.MethodsTwo hundred and one studies of 120 patients who underwent staging or restaging true whole body 18F‐FDG PET/CT for breast cancer were retrospectively identified. Any abnormal hypermetabolic or structural focus outside the limited FOV was recorded and characterised, and referenced with the patient's known disease status and any symptomatology.ResultsA total of 18 (9.0%) studies had FDG avid and/or structural abnormalities detected outside the limited whole‐body FOV which were identified as malignant. Seventeen out of 18 (94.4%) were skeletal and of these, 15/17 (88.2%) were located within the lower limbs. In three cases, there were de novo findings but identified in the presence of interval progression of other metastases within the limited whole‐body FOV. None of these additional findings is known to have resulted in a change to staging or clinical management.ConclusionIn the assessment of breast cancer, a true whole‐body PET/CT can reveal metastases outside the limited whole‐body FOV, but these are unlikely to be encountered in isolation and therefore may have little bearing on clinical stage or management. Ultimately, while the choice of FOV should still be based on the individual patient situation, routine utilisation of the true whole‐body FOV in the asymptomatic patient may not be necessary.
Implementing the optimized hippo‐avoidance prophylactic cranial irradiation for limited‐stage small cell lung cancer by tomotherapy and volumetric modulated arc therapy
Authors: Zhan Tian‐You , Deng Lei , Wang Wen‐Qing , Zhang Tao , Wang Jian‐Yang , Wang Xin , Liu Wen‐Yang , Zhai Yi‐Rui , Xiao Ze‐Fen , Feng Qin‐Fu , Bi Nan , Li Ye‐Xiong , Zhou Zong‐Mei 
Published: October 2024

AbstractBackgroundHippo‐avoidance prophylactic cranial irradiation (HA‐PCI) requires a hippocampal avoidance zone expanded from hippocampus to ensure dose fall‐off and compensate for setup errors. Most studies recommend a 5‐mm margin, while it could be optimized to a 2‐mm expansion. Here, we showed the details of optimized HA‐PCI for limited‐stage small cell lung cancer (LS‐SCLC).MethodsThis cohort study reviewed patients with LS‐SCLC receiving optimized HA‐PCI from August 2014 to June 2020 in the National Cancer Center of China. The hippo‐related dose parameters were summarized. The comparison of the Hopkins Verbal Learning Test—Revised (HVLT‐R) scores in different time points was conducted. The Kaplan–Meier method was used to calculate the survival rates.ResultsA total of 112 patients were included. The average doses of hippocampus and hippocampal avoidance zone were 6.80 Gy (IQR: 6.40–7.44) and 7.63 Gy (IQR: 7.14–8.39). No differences were observed in the two radiation techniques (tomotherapy [TOMO] vs. volumetric‐modulated arc therapy [VMAT]). The decline of HVLT‐R score remained in a low level and not significant in assessable patients (p = 0.095). With a median follow‐up of 52 months (95% CI: 47.2–56.7), the 2‐year overall survival and progression‐free survival were 74.1% and 50.0%, respectively. Two intracranial recurrence lesions (2.3%) located <2 mm from the hippocampus.ConclusionsOptimized HA‐PCI could achieve similar dose limitation by TOMO and VMAT techniques with favorable efficacy and minor toxicity.
Early Childhood Education and Care Attendance and Its Association With Outdoor Play, Screen Time and Sleep Duration of Young Children: Findings From the CHAT Trial in Australia
Authors: Xu Huilan , Phongsavan Philayrath , Kerr Erin , Simone Lisa , Rissel Chris , Wen Li Ming 
Published: October 2024

ABSTRACTBackgroundEffects of attending early childhood education and care (ECEC) on health behaviours of young children remain unclear. This study aimed to investigate whether ECEC attendance was associated with outdoor play, screen time, sleep duration and family demographics of children aged 2 and 3 years.MethodsSecondary analysis was conducted using data extracted from two linked trials conducted in Australia, 2017–2020. Telephone surveys were conducted with participating mothers for data collection. Multiple logistic and linear regression models were built to investigate the associations of ECEC attendance with outdoor play, screen time, sleep duration and family demographics among young children.ResultsAt ages 2 and 3 years, 797 and 537 mothers completed surveys, respectively. Of respondents, 65% and 72% of children attended ECEC, respectively. Children who attended ECEC had 17 min (95% CI 3.8–30.5) and 28 min (95% CI 14.1–41.9) more daily outdoor playtime and had 13 min (95% CI 4.0–21.5) and 19 min (95% CI 6.4–30.7) less daily screen time at home at 2 and 3 years, respectively. Although ECEC attendance was not associated with sleep duration, children who attended ECEC were more likely to meet all three recommendations (outdoor play, screen time and sleep) with adjusted odds ratio (AOR) 1.84 (95% CI 1.24–2.72) at age 2 and AOR 2.34 (95% CI 1.28–4.28) at age 3. Mothers who were employed, first‐time mothers, spoke English at home or had a high household income were more likely to use ECEC services.ConclusionsECEC services may hold promise to influence outdoor play and screen time among young children. Children from lower socio‐demographic background had a lower rate of ECEC attendance. Future health promotion programmes for young children need to also consider children who do not attend ECEC.
Favorable Prognosis in Patients With Multiple Myeloma and Lenalidomide‐Induced Skin Rash: A Multicenter Retrospective Study
Authors: Nakamura Ayumi , Kimura Yuta , Tanaka Yuka , Tsuchimoto Daisuke , Naruse Atsuhiko , Kanematsu Tetsufumi , Takeuchi Kento , Tomita Nobukazu , Miyazawa Kenji , Fukuoka Tomohiro , Mori Akiya , Tamaki Shinya , Fujioka Aiko , Yokoyama Satoshi , Ikeda Yoshiaki , Nagai Hirokazu 
Published: October 2024

ABSTRACTAlthough lenalidomide is an essential treatment for multiple myeloma (MM), skin rashes are a common adverse event. This retrospective study aimed to examine the association between skin rash development during lenalidomide treatment and the prognosis of relapsed/refractory MM. All patients who received lenalidomide at 10 hospitals between July 2009 and December 2015 were included in the study. The relationship of skin rash development with disease progression and survival was evaluated. Multivariate analysis was performed to identify factors affecting disease progression or survival, including skin rash. Of the 245 patients analyzed, 70 developed skin rashes. The median progression‐free survival (PFS) of patients with skin rashes was 22.4 months, whereas the median PFS for patients who did not develop skin rashes was 10.5 months (p = 0.003). The median overall survival for patients with and without skin rash was 42.6 and 24.6 months, respectively (p = 0.013). Multivariate regression analysis showed that skin rash was an independent prognostic factor for PFS (p = 0.009). In this study, patients with skin rashes during lenalidomide treatment had significantly better PFS than those without such symptoms, indicating that lenalidomide‐associated skin rashes may be a predictor of clinical outcomes in patients with MM.
Tremor after solid organ transplantation: Results from the TransplantLines Biobank and Cohort Study
Authors: van der Stouwe A. Madelein M. , Riemersma Niels L. , Knobbe Tim J. , Kremer Daan , Nolte Svea , Plasmeijer Danieke B. , Gomes‐Neto Antonio. W. , Bakker Stephan J. L. , Drost Gea , Elting Jan Willem J. 
Published: October 2024

AbstractBackground and purposeTremor is a frequent complaint of solid organ transplant recipients. We report on the largest population investigated with clinical neurophysiological methods. Our aim is to objectively establish the tremor prevalence and syndrome in the largest population of solid organ transplant recipients.MethodsTremor was measured in heart, kidney, liver, and lung recipients, using accelerometers during rest, postural, and weight‐loaded conditions. The 95th percentile of healthy kidney donors' tremor amplitude was used as the cutoff to determine the presence of tremor in transplant recipients. Tremor frequency, frequency variability, and effect of loading were used to investigate enhanced physiological tremor as the likely tremor syndrome. Impact on activities of daily life was assessed, and correlations with tacrolimus blood levels were investigated.ResultsTremor was present in 52% of 246 transplant recipients, typically in postural positions. Mean tremor frequency was 6.1 (±2.0) Hz; mean tremor variability was 2.6 (±1.8) Hz. A frequency decrease upon loading was found in 83% of patients with tremor. Sixty‐five percent of patients met formal clinical neurophysiological criteria for enhanced physiological tremor. Tremor‐related impairment was present in 55% and correlated with tremor amplitude (ρ = 0.23, p ≤ 0.001). In a binominal regression analysis, tacrolimus blood levels were independently associated with tremor prevalence (p = 0.009).ConclusionsMore than half of solid organ transplant recipients experience a tremor that best fits the syndrome of enhanced physiological tremor. This is the first objective study on tremor that has established a better understanding of the neurophysiological mechanisms of tremor in a large population of solid organ transplant recipients.
Evaluating novel in silico tools for accurate pathogenicity classification in epilepsy‐associated genetic missense variants
Authors: Montanucci Ludovica , Brünger Tobias , Boßelmann Christian M. , Ivaniuk Alina , Pérez‐Palma Eduardo , Lhatoo Samden , Leu Costin , Lal Dennis 
Published: October 2024

AbstractObjectiveDetermining the pathogenicity of missense variants in clinical genetic tests for individuals with epilepsy is crucial for guiding personalized treatment. However, achieving a definitive pathogenic classification remains challenging, with most missense variants still classified as variants of uncertain significance (VUS) and with the availability of many computational tools which may provide conflicting predictions. Here, we aim to evaluate the performance of state‐of‐the‐art computational tools in pathogenicity prediction of missense variants in epilepsy‐associated genes. This will assist in selecting the most appropriate tool and critically assess their use in clinical setting.MethodsWe assessed the performance of nine in silico pathogenicity prediction tools for missense variants in epilepsy‐associated genes on three carefully curated data sets. The first two data sets comprise missense variants in epilepsy associated genes that have been uploaded to ClinVar in the last year and were, therefore, not part of the training set of any of the nine considered tools. These two data sets are based on two different lists of epilepsy‐associated genes and comprise ~700 and ~ 250 missense variants, respectively. The third data set includes ~400 missense variants within epilepsy‐associated genes for which the functional effects have been determined experimentally and are therefore used here to infer pathogenicity. These three data sets represent the best available approximation to blind and independent test sets.ResultsAmong the nine assessed tools, AlphaMissense (area under the curve [AUC]: .93, .88, and .95) and REVEL (AUC: .93, .88, and .93) showed the best classification performance, also outperforming other tools in the number of classified variants.SignificanceWe show which recently developed prediction tools achieve higher performance in epilepsy‐associated genes and should be integrated, therefore, into the American College of Medical Genetics and Genomics/Association of Molecular Pathology (AGMC/AMP) variant classification process. Periodic reevaluation of genetic test results with newly developed or updated tools should be incorporated into standard clinical practice to improve diagnostic yield and better inform precision medicine.
When Do Tumours Develop? Neoplastic Processes Across Different Timescales: Age, Season and Round the Circadian Clock
Authors: Bieuville Margaux , Dujon Antoine M. , Raven Nynke , Ujvari Beata , Pujol Pascal , Eslami‐S Zahra , Alix Panabières Catherine , Capp Jean‐Pascal , Thomas Frédéric 
Published: October 2024

ABSTRACTWhile it is recognised that most, if not all, multicellular organisms harbour neoplastic processes within their bodies, the timing of when these undesirable cell proliferations are most likely to occur and progress throughout the organism's lifetime remains only partially documented. Due to the different mechanisms implicated in tumourigenesis, it is highly unlikely that this probability remains constant at all times and stages of life. In this article, we summarise what is known about this variation, considering the roles of age, season and circadian rhythm. While most studies requiring that level of detail be done on humans, we also review available evidence in other animal species. For each of these timescales, we identify mechanisms or biological functions shaping the variation. When possible, we show that evolutionary processes likely played a role, either directly to regulate the cancer risk or indirectly through trade‐offs. We find that neoplastic risk varies with age in a more complex way than predicted by early epidemiological models: rather than resulting from mutations alone, tumour development is dictated by tissue‐ and age‐specific processes. Similarly, the seasonal cycle can be associated with risk variation in some species with life‐history events such as sexual competition or mating being timed according to the season. Lastly, we show that the circadian cycle influences tumourigenesis in physiological, pathological and therapeutic contexts. We also highlight two biological functions at the core of these variations across our three timescales: immunity and metabolism. Finally, we show that our understanding of the entanglement between tumourigenic processes and biological cycles is constrained by the limited number of species for which we have extensive data. Improving our knowledge of the periods of vulnerability to the onset and/or progression of (malignant) tumours is a key issue that deserves further investigation, as it is key to successful cancer prevention strategies.
The experiences of children with Williams syndrome and their nondisabled siblings of their relationship
Authors: Cebula Katie , Gillooly Amanda , Coulthard Laura K. B. , Riby Deborah M. , Hastings Richard P. 
Published: October 2024

AbstractObjectiveThis study explored sibling relationships from the perspective of children with Williams syndrome (WS) and their nondisabled (ND) siblings.BackgroundWS, a genetic condition with a profile that can include intellectual disabilities, hypersociability and anxiety, might be predicted to impact sibling relationships, but this has not been qualitatively explored from the children's perspective.MethodsThirty‐nine children (6–17 years; 20 male, 19 female) participated: 20 sibling dyads in which one child had WS and the other was ND (one child with WS did not participate). Children were interviewed about experiences of their relationship. Data were analyzed with reflexive thematic analysis.ResultsSiblings described multifaceted relationships, in which love and positivity were overtly evident and embedded in the reciprocity of sibling expertise and support. Children skillfully navigated the spaces and boundaries of their relationship across home, school, and friendship contexts, with parent support. ND siblings' knowledge of WS supported interactions, relationships, and advocacy, but some children with WS felt their sibling lacked knowledge of the challenges of WS.ConclusionsThe WS profile was woven through multidimensional relationships.ImplicationsFindings have implications for how parents are supported to help siblings navigate relationships and learn about WS, and how schools support WS sibling relationships.