bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focusing on Enzyme Suppression in Neurodegenerative Disorders: Promising Approaches for Therapeutic Measures
Authors: Kumar Shivendra , Saha Sunam , Singh Talever , Tripathi Ram Babu , Singh Kuldeep , Dwivedi Vivek , Singh Shubham , Chandra Deep 
Published: September 2024

:
Neurodegenerative diseases, characterized by the progressive degeneration of neurons, represent a significant and growing global health concern.
Despite extensive research, the underlying molecular mechanisms driving these conditions remain elusive. Enzyme dysregulation has emerged as a
pivotal player in the pathogenesis of various neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases.
Understanding and targeting these enzymes hold immense therapeutic potential for mitigating disease progression. This abstract summarizes the
current state of knowledge regarding the involvement of enzymes in neurodegenerative diseases and explores the potential therapeutic
interventions aimed at enzyme inhibition. First, we provide an overview of the key enzymes implicated in each disorder and highlight their specific
roles in neurodegenerative processes. Next, we delve into the intricate interplay between enzyme dysregulation and disease progression,
elucidating the cascade of events leading to neuronal death and cognitive decline. Additionally, we explore promising preclinical and clinical
studies that have shown encouraging results in inhibiting specific enzymes, validating the therapeutic potential of targeting these pathways. In
conclusion, targeting enzyme inhibition in neurodegenerative diseases holds immense promise as a therapeutic avenue to slow disease progression
and improve patients' quality of life. Nevertheless, considerable challenges lie ahead, necessitating collaborative efforts among researchers,
clinicians, and pharmaceutical companies to develop safe, effective, and precise interventions for combating these devastating disorders. With
continued advancements in molecular biology and drug discovery, we remain optimistic that the targeted modulation of enzymes will pave the way
for innovative and transformative treatments in the realm of neurodegenerative diseases.
Identification of Peptidoglycan Glycosyltransferase FtsI as a Potential Drug Target against Salmonella Enteritidis and Salmonella Typhimurium Serovars Through Subtractive Genomics, Molecular Docking and Molecular Dynamics Simulation Approaches
Authors: Gulzar Imran , Khalil Asma , Ashfaq Usman Ali , Liaquat Sadia , Haque Asma 
Published: September 2024

Introduction:
Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium
are among the main causative agents of nontyphoidal Salmonella infections, imposing a significant global
health burden. The emergence of antibiotic resistance in these pathogens underscores the need for innovative
therapeutic strategies.

Objective:
To identify proteins as potential drug targets against Salmonella enteritidis and Salmonella typhimurium
serovars using in silico approaches.

Methods:
In this study, a subtractive genomics approach was employed to identify potential drug targets. The
whole proteome of Salmonella enteritidis PT4 and Salmonella typhimurium (D23580), containing 393 and 478
proteins, respectively, was analyzed through subtractive genomics to identify human homologous proteins of
the pathogen and also the proteins linked to shared metabolic pathways of pathogen and its host.

Results:
Subsequent analysis revealed 19 common essential proteins shared by both strains. To ensure hostspecificity,
we identified 10 non-homologous proteins absent in humans. Among these proteins, peptidoglycan
glycosyltransferase FtsI was pivotal, participating in pathogen-specific pathways and making it a promising
drug target. Molecular docking highlighted two potential compounds, Balsamenonon A and 3,3',4',7-Tetrahydroxyflavylium,
with strong binding affinities with FtsI. A 100 ns molecular dynamics simulation having
10,000 frames substantiated the strong binding affinity and demonstrated the enduring stability of the predicted
compounds at the docked site.

Conclusion:
The findings in this study provide the foundation for drug development strategies against Salmonella
infections, which can contribute to the prospective development of natural and cost-effective drugs targeting
Salmonella Enteritidis and Salmonella Typhimurium.
The Effect of Hydroxysafflor Yellow A on Inflammatory Injury in LPS-induced Endothelial Cell Injury Model through TLR4/NF-κB Pathway Based on Network Pharmacology and Experimental Verification
Authors: Guo Qinghua , Zhu Xiaoyan , Zhang Xiaoyang , Wang Xu , Fu Feida , She Wandong 
Published: September 2024

Objective:
The objective of this study is to search for hydroxysafflor yellow A
(HSYA) and Idiopathic sudden sensorineural hearing loss (ISSNHL)-related target genes and to
study the treatment effects of HSYA on lipopolysaccharide (LPS)-induced endothelial cell injury

Methods:
We used network pharmacology to screen molecules related to HSYA and ISSNHL,
then analyzed these molecules and their enriched biological processes and signaling pathways
via Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). We selected
inflammation-related hub genes for molecular docking determination by protein-protein interaction
(PPI) analysis, and further verified them with in vitro experiments.

Results:
Thirty-four HSYA-ISSNHL-related differential genes were obtained using drug-disease
differential gene screening using online tools. Three key proteins, NF-κB, CASP3, and
MAPK1, were selected according to Degree > 20. Among them, NF-κB is closely related to
inflammation and ISSNHL. In in vitro experiments, HSYA reduced inflammatory (IL-6, TNF-
α) and oxidative stress (ROS, SOD and MDA) indicators after LPS intervention, and the expression
of NF-κB-related signaling pathway genes.

Conclusion:
HSYA may reduce inflammation and oxidative stress by inhibiting the expression
of the TLR4 / NF-κB-related signaling pathway, therefore protecting endothelial cells, which
might be a potential mechanism of HSYA in ISSNHL treatment.
Effects of Long-Term Inhaled Corticosteroid Therapy on Metabolic And Anthropometric Parameters in Pediatric Patients with Asthma
Authors: Heidari Solmaz , Fathi Mohammadreza , Aminzadeh Majid , Torabizadeh Mehdi , Nasehi Najimeh , Valavi Ehsan , Mohammadi Shooka 
Published: September 2024

Background:
Long-term impacts of inhaled corticosteroids (ICSs) on metabolic parameters
of asthmatic children are still uncertain.

Objective:
This study aimed to evaluate the effects of long-term use of ICSs on metabolic and anthropometric
measures among children with asthma in Iran.

Methods:
This case-control study was conducted among 200 pediatric asthmatic patients who
were referred to Abuzar Hospital (Ahvaz, Iran) during nine months. Demographic and clinical data
of the patients were recorded. The participants were categorized into two groups: Group 1 (n =
100) comprising children with moderate to severe asthma, and Group 2 (n = 100) consisting of
those with mild asthma.

Results:
The average age of 200 patients was 8.1 ± 2.9 years. The majority of them were male.
The prevalence of wasting, stunting, obesity, and overweight was higher among Group 1 compared
to Group 2 (p < 0.05). Patients in Group 1 had significantly higher levels of calcium, vitamin
D, lipids, and glycemic parameters than those in Group 2 (p < 0.05). In addition, the duration
of ICS use was notably longer in Group 1 (p < 0.05).

Conclusion:
Children with moderate and severe asthma had significantly elevated lipid and
glycemic parameters, as well as a higher prevalence of wasting, stunting, obesity, and overweight
compared to patients with mild asthma. Further studies involving larger sample sizes and longer
durations are necessary to confirm these findings.
Effect of Ginger Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis
Authors: Shoaibinobarian Nargeskhatoon , Riahi Roya , Heidari-Beni Motahar , Kelishadi Roya 
Published: September 2024

Background:
Ginger (Zingiber officinale), as one of the herbal medicines, has high antioxidant
activity. It may have protective effects against hepatotoxicity. This study seeks to perform
a systematic review and meta-analysis on the impact of ginger on liver enzymes.

Methods:
The present systematic review and meta-analysis study adhered to the guidelines outlined
in the PRISMA 2020 statement. A comprehensive literature search was carried out in the
Medline database (PubMed), Google Scholar, Embase, Scopus, Web of Science, and Cochrane Library
until the conclusion of February 2021. All interventional animal studies were included. The
selected studies were the ones that examined the impact of ginger on serum liver enzymes.

Results:
Out of 741 articles, 39 studies were incorporated into the systematic review and meta-analysis.
The pooled results suggested that ginger significantly reduced alanine aminotransferase
(ALT) (standardized mean difference (SMD): 2.52, 95% confidence interval (CI): 2.12 to 2.93),
aspartate aminotransferase (AST) (SMD: 3.03, 95% CI: 2.48 to 3.58), and alkaline phosphatase
(ALP) (SMD: 2.10, 95% CI: 1.60 to 2.60).

Conclusion:
Ginger has favorable effects on liver enzymes. It shows potential as a beneficial complementary
therapy for higher levels of ALT, AST, and ALP because of its useful effects and negligible
side effects.
Validation of Renal Function using Multiphasic Ratios between Renal Cortex and Medulla in Kidney Recipients
Authors: Wang Chao , Song Yancheng , Pan Zhibin , Li Guoce , Zhang Lei , Bian Hao , Liu Fenghai , Yuan Xiaodong 
Published: September 2024

Objective:
To verify the multiphase ratio of Computer Tomography-value between the renal cortex and renal medulla, which can be used to concisely
evaluate renal function in kidney recipients.

Methods:
Fifty-eight kidney recipients were retrospectively enrolled and divided into the Normal group(eGFR≥90 mL/min/1.73m2) and Abnormal
group(eGFR<90 mL/min/1.73m2) according to Chronicle Kidney Disease Epidemiology Collaboration (eGFR(CKD-EPI)) and the Modular of Diet
in Renal Disease (eGFR(MDRD)) formulas respectively. The multiphasic ratios between the renal cortex and medulla in the arterial phase and
venous phase were noted as A(RatioC/M) and V(RatioC/M), and the difference between those two was recorded as D(RatioC/M). Correlation/regression
analysis, student t-test, and ROC curves analysis were used to test the ability of multiphasic ratios to assess renal function.

Results:
Both A(RatioC/M) and V(RatioC/M) were moderately correlated with eGFR(CKD-EPI) (Y =20.41*X + 28.20, r=0.40 (95%Cl, 0.13-0.58), P<0.01; Y
=-16.57*X + 109.8, r=-0.29 (95%Cl, -0.51--0.04), P=0.03) and eGFR(MDRD) (Y =23.72*X + 23.52, r=0.38 (95%Cl, 0.13-0.58), P<0.01; Y
=-19.88*X + 119.5, r=-0.30 (95%Cl, -0.52--0.05), P=0.02). However, D(RatioC/M) was strongly positive correlated with eGFR(CKD-EPI) (Y =
30.95*X + 60.71, r=0.61 (95%Cl,0.42-0.75), P<0.001) and eGFR(MDRD) (Y = 36.47*X + 61.01, r=0.62 (95%Cl, 0.44-0.76), P<0.001),
respectively, and both regression lines were not significant different (slope: P=0.496, intercept: P=0.378). The differences in D(RatioC/M) between
the two groups were significant (all P<0.05). The ROC curve analysis provided the cutoff values of D(RatioC/M) for assessing eGFR (AUC:0.863
and AUC:0.822, all P<0.001).

Conclusion:
The D(RatioC/M) can be used to assess renal function for kidney recipients.
Unveiling the Anti-cancer Potential of Oxadiazole Derivatives: A Comprehensive Exploration of Structure-Activity Relationships and Chemico-Biological Insights
Authors: Mishra Sai Satyaprakash , Samanta Ajeya , Paul Abhik , Maji Avik , Maity Tapan Kumar 
Published: September 2024

Background:
Oxadiazole derivatives have shown significant potential as anti-cancer
agents with low μM potencies. Some examples of drugs in this class include Raltegravir, Zibotentan,
Setileuton (MK-0633), Nesapidil, Furamizole, and Tidazosin. The presence of the oxadiazole
nucleus in Raltegravir exemplifies its importance in drug development, showcasing how specific
structural motifs like oxadiazole can be strategically incorporated into molecules to achieve
desired therapeutic effects. A large number of researchers across the globe have already developed
and reported many oxadiazoles as potential anti-cancer medicines.

Objective:
Therefore, we tried to discuss the anti-cancer potentials of oxadiazole derivatives reported
between 2019 and 2023. The design strategies, structure-activity relationship (SAR), and protein-
inhibitor interactions of potential compounds on different targets have to be identified to help
the medicinal chemists design new drug-likeness oxadiazole molecules for anti-cancer therapy.
Similarly, the ADMET profiles of potential oxadiazoles using the in silico SWISSADME tool have
to be studied.

Results:
We have highlighted the recently reported most potent oxadiazole derivatives as well as
their hybrid compounds. The SAR study revealed that oxadiazole-linked pyridine, indazole, thiadiazine,
quinoxaline, thiazolidine, indeno-pyrazole, thiophene, piperidine, benzimidazole, triazole,
and sulphonamide showcased promising anti-cancer action. The chemico-biological interactions of
potential oxadiazole compounds suggest good interactions with different amino acid residues that
make them possible candidates for developing novel and effective anti-cancer therapies. Similarly,
the in silico ADMET report suggested favourable physicochemical, pharmacokinetic, and druglikeness
properties of potential oxadiazole compounds.

Conclusion:
Overall, these results will prove to be a helpful and vital tool for medicinal chemists
investigating and working with oxadiazoles for anti-cancer action.
Exploring the Bioactive Constituents and Pharmacological Activity of Scutellaria baicalensis Georgi, or Chinese Skullcap
Authors: Singh Sonia , Tiwari Suryansh , Agrawal Ronak 
Published: September 2024

Introduction:
Scutellaria baicalensis Georgi, a plant with therapeutic properties, has
been extensively utilized in China for centuries. The extract derived from its roots is commonly
referred to as Huang-Qin.

Materials and Methods:
The informative data were gathered from many electronic databases,
including Scopus, Science Direct, PubMed, and Web of Science. The study criteria for selection
included analyzing scientific manuscripts that specifically investigated phytoconstituents and
their pharmacological effects. The keywords used were Scutellaria baicalensis, bioactive components,
and pharmacological profile.

Discussion:
The main concern of this study is to enhance the accessibility of extensive research
discoveries about the pharmacological potential of S. baicalensis.

Results:
S. baicalensis root has been utilized to manage dysentery, diarrhea, hypertension, insomnia,
inflammation, respiratory infections, and hemorrhaging. Wogonoside and baicalin are the
primary bioactive constituents obtained from S. baicalensis root. The flavones have been documented
to possess many pharmacological properties, such as hepatoprotective, anti-cancer, antibacterial,
antioxidant, antiviral, neuroprotective, and anticonvulsant activities.

Conclusion:
This manuscript's main concern is to enhance the accessibility of extensive research
discoveries about the pharmacological potential of S. baicalensis.
Fabrication of Ti/Zr-SnO2/PbO2-Nd Electrode for Efficient Electrocatalytic Degradation of Alizarine Yellow R
Authors: Zhang Jing , Yang Bi , Gao Guan-Jin , Miao Qing-Dong , Hu Wei-Guo , Yu Jin-Gang 
Published: September 2024

Introduction:
A novel attempt to degrade alizarine yellow R (AYR) by lead dioxide
(PbO2)/ neodymium (Nd) coated Ti anode was investigated.

Method:
Ti/Zr-SnO2/PbO2-Nd electrode showed high oxygen evolution potential, high current
density, and neutral conditions, which favored the degradation of AYR. The PbO2-Nd layer on
Ti/Zr-SnO2 was further characterized by scanning electron microscopy, and X-ray diffraction
analysis, and X-ray photoelectron spectroscopy. The electrochemical properties of Ti/Zr-
SnO2/PbO2-Nd electrode were evaluated by cyclic voltammetry, AC impedance spectroscopy,
and accelerated life test.

Result:
The relatively higher oxygen evolution overpotential (~1.80 V) of the developed electrode
can effectively suppress the occurrence of surface side reactions and oxygen evolution. A
relatively lower charge transfer resistance (Rct, 18.0 Ω) of Ti/Zr-SnO2/PbO2-Nd electrode could
be found. The Ti/Zr-SnO2/PbO2-Nd electrode exhibited an accelerated lifetime of 110 min under
a very high current density of 10,000 A/m2. The doping of Nd could produce loosely-stacked
sheet-like structures, thus, the number of active sites on the electrode surface increases.

Conclusion:
Moreover, an outstanding conductivity of Ti/Zr-SnO2/PbO2-Nd electrode was obtained,
which favored the electron transfer and catalytic activity of the modified electrode. The
Ti/Zr-SnO2/PbO2-Nd electrode exhibited improved electrochemical performances and higher
oxygen evolution potential, and the highest oxygen evolution potential is 1.80 V. Under the current
density of 30 mA/cm2, the electrocatalytic degradation of 92.3% could be achieved in 180
min. The electrochemical oxidation of AYR at the Ti/Zr-SnO2/PbO2-Nd electrode proved to be
feasible and effective, indicating that it might be used for the elimination of AYR from
wastewater.

conclusion:
The electrochemical oxidation of AYR at the Ti/Zr-SnO2/PbO2-Nd electrode proved to be feasible and effective, indicating that it might be used for the elimination of AYR from wastewater.
Empowering Natural Medicine: Nanocarrier-based Oral Delivery of Vigna radiata Extract for Effective Diabetes Management
Authors: Sharma Bhawna , Kumar Gaurav , Chauhan Iti , Tiwari Raj Kumar 
Published: September 2024

Background:
Poor solubility and low oral bioavailability are major challenges associated
with the oral delivery of the antidiabetic drug Vigna radiata (VR). Nanostructured lipid carriers
(NLCs) have emerged as a promising strategy to overcome these limitations and improve the therapeutic
efficacy of VR. This study investigated the potential of NLCs for VR delivery and explored
the influence of formulation parameters on NLC properties and drug release behavior.

Methods:
NLCs loaded with VR were prepared using the melt emulsion ultrafiltration technique. The
effect of two key formulation variables – the ratio of liquid lipid to solid lipid and the concentration
of the surfactant – were investigated in terms of particle size, zeta potential, and drug encapsulation
efficiency. The in vitro release profiles of the VR-NLC formulations were evaluated, and the optimal
formulation was subjected to further analysis to investigate its release kinetics.

Results:
The NLCs exhibited particle sizes ranging from 108.9 to 192.3 nm and all formulations possessed
a negative zeta potential (-3.68 to -10.9 mV), indicating good stability and potential for resisting
aggregation. Interestingly, the lowest solid lipid to liquid lipid ratio and the lowest surfactant
concentration yielded the highest drug encapsulation efficiency, highlighting the complex interplay
between these factors. All VR-NLC formulations exhibited a biphasic, time-dependent in vitro release
pattern, suggesting an initial burst release followed by a sustained release phase. This biphasic
profile is promising for achieving both rapid onset of action and long-lasting glycemic control, which
are crucial aspects of effective diabetes management.
The optimized NLC formulation showed an in vitro release pattern that adhered to the Higuchi diffusion
model, suggesting a controlled release mechanism where the drug diffuses steadily out of the
NLC matrix. This finding indicates potentially predictable and consistent drug delivery in vivo.

Conclusion:
This study demonstrates the potential of NLCs as a promising platform for the controlled
oral delivery of VR. NLCs can overcome the inherent limitations of VR and provide a convenient
and effective oral antidiabetic option for patients. Further research is needed to confirm the
efficacy and safety of NLC-encapsulated VR in vivo using relevant animal models. This will pave
the way for the development of a novel and potentially transformative treatment option for diabetes.
ANALISIS PENINGKATAN KESEJAHTERAAN MUSTAHIK DARI SEGI SPIRITUAL DAN MATERIAL MENGGUNAKAN METODE CIBEST (STUDI KASUS: PROGRAM KUM DI YDSF MALANG)
Authors: Naufal Mahadika Driantama  , Sri Muljaningsih  
Published: September 2024

Poverty in Indonesia is a complex and structured problem. Therefore, comprehensive policies are needed to address poverty. Empowerment of hive-based, productive-based societies can have a positive and optimal impact on reducing poverty, while also improving the economic well-being. Cibest's methods become one of the alternatives to measure the impossible's spiritual and material well-being. The purpose of this study is to determine poverty conditions before and after receiving help from poor kum DSF program and to see the role of laznas in empowering zakat. The research methods used use a descriptive quantitative analysis approach and use primary data. The source of this research is umkm the beneficiary of the wretched kum YDSF program. In the data collection technique using a likert scale questionnaire. The result of this study was that the first change in living conditions in quadrant ii (poor spiritually) was 7 mustahik, reducing only 2 improbable. It is impossible to move to the prosperous quadrant of spiritual and material prosperity. For the capitals financing financing scheme of empowering the mustahik at the poverty poverty is divided into four elementary, pre intermediate, intermediate, and advanced classes.
Pengaruh Brand Image, Celebrity Endorser Dan Online Customer Review Terhadap Keputusan Pembelian
Authors: Maulida Sesha Rizkina , Yuana Pusvita 
Published: September 2024

The objective of this research is to identify the effects of brand image, celebrity endorser, and online customer review on the purchase decision towards Skintific products through TikTok Shop application. Using purposive sampling technique, 120 users of TikTok Shop who have bought the product of Skintific at least once were selected as the respondents. The data of this quantitative explanatory research was harvested via questionnaires and was analyzed using Structural Equation Modeling (SEM) in PLS 3.0. This study finds that the better the brand image of Skintific, the higher the purchase decision. This research also finds that celebrity endorser significantly and positively affects the purchase decision and that online customer review positively and significantly influences the purchase decision. Consumers can look for information about the products they want and read the reviews made by other consumers in order to make the right decision in their purchase.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh brand image, celebrity endorse dan online customer review terhadap keputusan pembelian produk Skintific pada aplikasi Tiktok Shop. Untuk mencapai tujuan tersebut, peneliti menggunakan penelitian eksplanatori dengan pendekatan kuantitatif. Teknik sampling yang digunakan adalah purposive sampling, peneliti mendapatkan sampel sebanyak 120 responden yang memiliki kriteria minimal membeli produk dari Skintific sebanyak 1 kali serta konsumen yang menggunakan Tiktok Shop. Pengumpulan data dilakukan menggunakan kuesioner. Kemudian data diolah menggunakan teknik statistik analisis Structural Equation Model (SEM) menggunakan aplikasi PLS 3.0. Hasil penelitian menunjukkan bahwa bila brand image Skintific semakin baik maka dapat meningkatkan keputusan pembelian. Celebrity endorse berpengaruh signifikan dan positif terhadap keputusan pembelian serta online customer review yang baik di Tiktok Shop akan mempengaruhi keputusan pembelian secara signifikan dan positif. Konsumen dapat terlebih dahulu mencari informasi kosmetik Skintific yang diinginkan dan melihat ulasan yang diberikan konsumen lain supaya tidak salah dalam memutuskan untuk membeli.