bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer‐reviewed articles on inclusive research: Do co‐researchers with intellectual disabilities have a voice?
Authors: Strnadová Iva , Walmsley Jan 
Published: June 2017

BackgroundInclusive research is increasingly common in intellectual disabilities research, but ways in which voice of co‐researchers with intellectual disabilities is presented remain underexplored in the literature.Materials and MethodThe authors conducted a literature review and analysis of peer‐reviewed journal articles reporting on inclusive research. The aim was to explore the ways the voices of co‐researchers with intellectual disabilities are represented in published peer‐reviewed journal articles.ResultsThe findings indicate that there are a wide range of ways in which inclusive research projects are reported in peer‐reviewed journals. However, the experiences, views and opinions of co‐researchers are often either absent or very selectively reported.ConclusionsThe article concludes that although inclusive research has proliferated in the 21st century, more attention needs to be paid to the ways in which the voices of co‐researchers with intellectual disabilities are heard in formal academic contexts. Guidelines for future practice are offered.
Need for closure and reactions to innovation
Authors: Chernikova Marina , Kruglanski Arie , Giovannini Dino , Vezzali Loris , Su Junjie 
Published: June 2017

AbstractIn two studies using Italian (N = 852) and American (N = 94) samples, we hypothesized that high NFC individuals would have lower intentions to use new technological developments, and that this relationship would be mediated by anxiety about the new technology. We found support for this hypothesis in Study 1, but not Study 2. In the second study, we found that the closed‐mindedness subscale of the full NFC scale was related to greater anxiety about new technology, which in turn led to lower intentions to use the new technology. This suggests that the closed‐mindedness facet of NFC may have been responsible for our results. A meta‐analytic synthesis of both studies provided some support for our original mediation hypothesis.
The impact of an automated learning component against a traditional lecturing environment
Authors: Maycock K.W. , Keating J.G. 
Published: June 2017

AbstractThis experimental study investigates the effect on the examination performance of a cohort of first‐year undergraduate learners undertaking a Unified Modelling Language (UML) course using an adaptive learning system against a control group of learners undertaking the same UML course through a traditional lecturing environment. The adaptive learning system uses two components for the creation of suitable content for individual learners: a content analyser that automatically generates metadata describing cognitive resources within instructional content and a selection model that utilizes a genetic algorithm to select and construct a course suited to the cognitive ability and pedagogic preference of an individual learner, defined by a digital profile. Using the Kruskal–Wallis H test, it was determined that there was a statistically significant difference between the control group of learners and the learners that participated in the UML course using the adaptive learning system following an examination once the UML course concluded, with p = 0.005, scoring on average 15.71% higher using the adaptive system. However, this observed statistically significant difference observed a small effect size of 20%.
MDM2 is implicated in high‐glucose‐induced podocyte mitotic catastrophe via Notch1 signalling
Authors: Tang Hui , Lei Chun‐Tao , Ye Chen , Gao Pan , Wan Cheng , Chen Shan , He Fang‐Fang , Wang Yu‐Mei , Su Hua , Zhang Chun 
Published: June 2017

AbstractPodocyte injury and depletion are essential events involved in the pathogenesis of diabetic nephropathy (DN). As a terminally differentiated cell, podocyte is restricted in ‘post‐mitosis’ state and unable to regenerate. Re‐entering mitotic phase will cause podocyte disastrous death which is defined as mitotic catastrophe (MC). Murine double minute 2 (MDM2), a cell cycle regulator, is widely expressed in renal resident cells including podocytes. Here, we explore whether MDM2 is involved in podocyte MC during hyperglycaemia. We found aberrant mitotic podocytes with multi‐nucleation in DN patients. In vitro, cultured podocytes treated by high glucose (HG) also showed an up‐regulation of mitotic markers and abnormal mitotic status, accompanied by elevated expression of MDM2. HG exposure forced podocytes to enter into S phase and bypass G2/M checkpoint with enhanced expression of Ki67, cyclin B1, Aurora B and p‐H3. Genetic deletion of MDM2 partly reversed HG‐induced mitotic phase re‐entering of podocytes. Moreover, HG‐induced podocyte injury was alleviated by MDM2 knocking down but not by nutlin‐3a, an inhibitor of MDM2‐p53 interaction. Interestingly, knocking down MDM2 or MDM2 overexpression showed inhibition or activation of Notch1 signalling, respectively. In addition, genetic silencing of Notch1 prevented HG‐mediated podocyte MC. In conclusion, high glucose up‐regulates MDM2 expression and leads to podocyte MC. Notch1 signalling is an essential downstream pathway of MDM2 in mediating HG‐induced MC in podocytes.
Predictive ANN models for the optimization of extra virgin olive oil clarification by means of vertical centrifugation
Authors: Funes Estrella , Allouche Yosra , Beltrán Gabriel , Aguliera M. Paz , Jiménez Antonio 
Published: June 2017

AbstractEight artificial neural networks were developed as predictive models for regulated and nutritional parameters of oils obtained from vertical centrifugation. The networks were designed considering the NIR spectra of oily must at its exit from the horizontal decanter centrifuge, and the flows and temperatures of the oil and of the addition water. The results obtained in all the networks designed indicated the good creative capacity of the neural models through their quality indicators (RER and RPD). The correlations between the real data and those predicted by the networks were within the range of 0.76–0.99, the UV absorption networks (K232 and K270) being those which gave lower correlations. For polyphenols, tocopherols and carotene and chlorophyll pigments, the te‐Student external validation test makes a reliable prediction of these parameters. With predictive models, the vertical centrifuge can be modeled and regulated as well as monitored on‐line to control and optimize the clarification phase within the extraction process of extra virgin olive oil (EVOO).Practical applicationsThe predictive ANN can use to regulate and model the vertical centrifuge to obtain an EVOO of a maximum regulated and nutritional quality possible, reducing water and energy consumption. Besides, with on‐line prediction of oil characterization, it will be possible to perform a correct classification prior to its storage in the cellar.
Life Cycle Assessment of 3D Printed Products in a Distributed Manufacturing System
Authors: Cerdas Felipe , Juraschek Max , Thiede Sebastian , Herrmann Christoph 
Published: June 2017

SummaryMotivated by the rising costs of doing business overseas and the rise and implementation of digital technologies in production, new strategies are being explored to bring production and demand closer. While concepts like cloud computing, internet of things, and digital manufacturing increasingly gain relevance within the production activities of manufacturing companies, significant advances in three‐dimensional (3D) printing technologies offer the possibility for companies to accelerate product development and to consider new supply chain models. Under this production scheme, material supply chains are redefined and energy consumption hotspots are relocated throughout the life cycle of a product. This implies a diversification of energy mixes and raw material sources that poses a risk of shifting problems between life cycle phases and areas of protection. This study compares a conventional mass scale centralized manufacturing system against a 3D printing‐supported distributed manufacturing system on the basis of the production of one frame for eyeglasses using the life cycle assessment methodology. The study indicates clearly that the optimization potential is concentrated mainly in the energy consumption at the unit process level and exposes a close link to the printing material employed.
(Re)constructing Family Images: Stepmotherhood Before Biological Motherhood
Authors: Sanner Caroline , Coleman Marilyn 
Published: June 2017

AbstractStrong cultural values and ideals attached to women in families deem the role of stepmother as inferior to that of biological mother. Although biological motherhood is celebrated, stepmotherhood is stigmatized, and women who wish to become mothers but become stepmothers prior to having biological children may grieve the loss of images surrounding normative ideals of creating a family. Using a feminist family science approach, the purpose of this grounded theory study was to explore the experiences of women without children in their transition to stepmotherhood. Interviews with 23 stepmothers (aged 26–47) revealed that women engaged in an internal process of creating and then adjusting personal images of family life to accommodate their new family circumstances. The process of (re)constructing family images had implications for later adjustment to stepmotherhood. Notions of the motherhood hierarchy emerged to depict the unique experiences of women who became stepmothers prior to having biological children.
ORGANIC GEOCHEMISTRY OF THE LOWER SILURIAN TANEZZUFT FORMATION AND BIOMARKER CHARACTERISTICS OF CRUDE OILS FROM THE GHADAMES BASIN, LIBYA
Authors: El Diasty W. Sh. , El Beialy S. Y. , Fadeel F. I. , Peters K. E. , Batten D. J. 
Published: June 2017

The Ghadames Basin of NW Libya contains more than 10 B brls oil‐equivalent in Palaeozoic siliciclastic reservoirs which are charged by organic‐rich “hot shales” in the Lower Silurian (Rhuddanian) Tanezzuft Formation. Geochemical analysis of 85 shale samples and ten oils from three fields (NC2, NC4 and NC7) in the central and northern part of the basin provides a robust description of the Tanezzuft – Mamuniyat/Acacus petroleum system in this region, and of the associated source facies and oil families. The shale samples underwent total organic carbon (TOC) analysis and Rock‐Eval pyrolysis, and the ten crude oil samples were analysed by gas chromatography – flame ionization detection (GC‐FID) and GC‐mass spectrometry (GC‐MS) of the saturated and aromatic hydrocarbon fractions, accompanied by stable carbon isotopic analysis. Organic matter ranges from Type II to mixed Type II/III kerogen with varying oil and gas generation potential in the early to main stages of the oil generation window.The analysed oils are characterised by low sulphur, nickel and vanadium contents, and relatively high API gravity (34.9–46.8oAPI). Biomarkers suggest that they were generated from marine shales containing abundant Type II to mixed Type II/III kerogen deposited in mildly anoxic – suboxic conditions with a dominance of C29 over C27 or C28 steranes, indicative of a source rich in brown algae and cyanobacteria. Their close stratigraphic association and biomarker characteristics support a Tanezzuft “hot shales” source for the Mamuniyat and Acacus oils in the three fields. Maturity‐related parameters based on terpanes, steranes, aromatic hydrocarbons and low molecular‐weight hydrocarbons, suggest generation from marine shales in the early to peak oil‐generation window. The ZE3‐NC7, A19‐NC7 and A20 NC7 oils from the NC7 oil field are significantly more mature than those from the NC2 and NC4 fields. This indicates a difference in expulsion timing and may be related to the presence of two “hot shales” or to fault‐triggered vertical migration preceding and during the Neogene.
Habitual sleep and kidney function in chronic kidney disease: the Chronic Renal Insufficiency Cohort study
Authors: Knutson Kristen L. , Lash James , Ricardo Ana C. , Herdegen James , Thornton J. D. , Rahman Mahboob , Turek Nicolas , Cohan Janet , Appel Lawrence J. , Bazzano Lydia A. , Kurella Tamura Manjula , Steigerwalt Susan P. , Weir Matthew R. , Van Cauter Eve ,   Cric Study Investigators
Published: June 2017

SummaryPhysiological evidence suggests that sleep modulates kidney function. Our objective was to examine the cross‐sectional association between kidney function and objectively‐estimated habitual sleep duration, quality and timing in a cohort of patients with mild to moderate chronic kidney disease. This study involved two US clinical centers of the Chronic Renal Insufficiency Cohort (CRIC) study, including 432 participants in a CRIC ancillary sleep study. Habitual sleep duration, quality and timing were measured using wrist actigraphy for 5–7 days. Validated sleep questionnaires assessed subjective sleep quality, daytime sleepiness and risk of sleep apnea. Kidney function was assessed with the estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration equation, and the urinary protein to creatinine ratio. Lower estimated glomerular filtration rate was associated with shorter sleep duration (−1.1 mL min−1 1.73 m−2 per hour less sleep, P = 0.03), greater sleep fragmentation (−2.6 mL min−1 1.73 m−2 per 10% higher fragmentation, P < 0.001) and later timing of sleep (−0.9 mL min−1 1.73 m−2 per hour later, P = 0.05). Higher protein to creatinine ratio was also associated with greater sleep fragmentation (approximately 28% higher per 10% higher fragmentation, P < 0.001). Subjective sleep quality, sleepiness and persistent snoring were not associated with estimated glomerular filtration rate or protein to creatinine ratio. Thus, worse objective sleep quality was associated with lower estimated glomerular filtration rate and higher protein to creatinine ratio. Shorter sleep duration and later sleep timing were also associated with lower estimated glomerular filtration rate. Physicians treating patients with chronic kidney disease should consider inquiring about sleep and possibly sending for clinical sleep assessment. Longitudinal and interventional trials are needed to understand causal direction.
Eradication of hepatitis C virus profoundly prolongs survival in hepatocellular carcinoma patients receiving transarterial chemoembolization
Authors: Teng W. , Hsieh Y.‐C. , Lui K.‐W. , Chen W.‐T. , Hung C.‐F. , Huang C.‐H. , Chen Y.‐C. , Jeng W.‐J. , Lin C.‐C. , Lin C.‐Y. , Lin S.‐M. , Sheen I.‐S. 
Published: June 2017

SummaryAdjuvant pegylated interferon plus ribavirin treatment (PegIFN/RBV) reduces recurrence and prolongs survival in early stage hepatocellular carcinoma (HCC) patients with chronic hepatitis C (CHC) infection receiving resection or ablation. However, the impact of antiviral therapy in intermediate and advanced stage of CHC‐HCC patients is uncertain. This study aimed to investigate the impact PegIFN/RBV treatment on recurrence‐free interval and survival in patients with HCC receiving transarterial chemoembolization (TACE). From 2010 to 2013, 274 CHC patients from a 1073 patient‐based cohort composed of freshly diagnosed HCC and receiving TACE treatment the Chang Gung Memorial Hospital, Linkou Medical Center were recruited. Propensity score matching (PSM) (age, gender, AST to Platelet Ratio Index (APRI), tumour size, tumour number and Child‐Turcotte‐Pugh score) with the ratio 1:2 for patients with and without PegIFN/RBV treatment was performed. Statistics were performed with SPSS V.20 (IBM, USA). After matching, 153 patients were analysed and 27 patients (17.6%) achieved sustained virologic response (SVR). The 2‐year cumulative overall survival rate and recurrence‐free survival rate among patients with SVR, non‐SVR, and untreated were 85.2% vs 58.3% vs 69.6% (P=.001) and 73.3% vs 53.8% vs 58.5% (P=.013). By Cox regression analysis, non‐SVR, untreated, increase CTP score and nonresponder to TACE were independent factors related to mortality. The SVR achieved by PegIFN/RBV treatment markedly improves survival and reduces tumour recurrence in CHC‐HCC patients receiving TACE treatment after complete response.
Living in a harsh habitat: epidemiology of the whale louse, Syncyamus aequus (Cyamidae), infecting striped dolphins in the Western Mediterranean
Authors: Fraija‐Fernández N. , Fernández M. , Gozalbes P. , Revuelta O. , Raga J. A. , Aznar F. J. 
Published: June 2017

AbstractWhale lice (Cyamidae) are ectoparasitic amphipods exclusive to cetaceans. Data on their epidemiology usually come from species infecting baleen whales, which are large, slow‐moving hosts. In this study, we provide data on infection parameters, population structure and microhabitat selection in a whale louse exclusive to delphinids, Syncyamus aequus, with the aim of comparing them with those from cyamid species from large whales. A total of 176 striped dolphins Stenella coeruleoalba stranded along the Mediterranean coast of Spain during 1980–2016 were examined. The prevalence of S. aequus was 27.3% (95% CI: 20.9–34.3), and populations were sparse, with a mean number of whale lice per infected host of just 4.5 (3.4–6.7). The parasites were found on the head, with a clearly nested pattern, with the blowhole being the most frequently occupied site, followed by the mouth corner and eyes. Single‐male or single‐female populations were found on as much as 39.6% of infected dolphins. The sex ratio did not significantly depart from 1:1. Females were significantly larger than males and exhibited low fecundity (<10 eggs). The sex or the age class of the dolphins did not significantly affect the abundance or population structure of S. aequus. The patterns here obtained are in sharp contrast with those reported for whale lice infecting large whales. The small, streamlined body of dolphins creates strong current flows that would restrict the amount of suitable microhabitats and the body size of their associated cyamids. This would limit population growth, which in turn would lower the chances of host‐to‐host transmission upon body contacts, as well as male competition for the access to females.
Lack of population genetic structure in the marine nematodes Ptycholaimellus pandispiculatus and Terschellingia longicaudata in beaches of the Persian Gulf, Iran
Authors: Sahraean Narjes , Van Campenhout Jelle , Rigaux Annelien , Mosallanejad Hadi , Leliaert Frederik , Moens Tom 
Published: June 2017

AbstractWe investigated genetic diversity and population genetic structure of two common benthic nematode species, Ptycholaimellus pandispiculatus and Terschellingia longicaudata, from sandy beaches in the area of Bandar Abbas (Iran), Persian Gulf. Based upon partial mitochondrial cytochrome oxidase c subunit 1 (COI) gene data, 17 and two haplotypes were found for P. pandispiculatus and Te. longicaudata, respectively. Analysis of molecular variance did not reveal a significant population genetic structure for either species. The absence of genetic structuring indicates substantial dispersal and gene flow in our study area. To assess the species structure of Te. longicaudata at a larger geographic scale, we compared 18S rDNA and COI sequences from Iran and the Scheldt Estuary in The Netherlands to ascertain whether they truly belong to the same species. Our data confirmed previous studies that Te. longicaudata likely constitutes a complex of multiple cryptic species, with one of these species having a (near) cosmopolitan distribution.
Over 10 years of variation in Mediterranean reef benthic communities
Authors: Betti Federico , Bavestrello Giorgio , Bo Marzia , Asnaghi Valentina , Chiantore Mariachiara , Bava Simone , Cattaneo‐Vietti Riccardo 
Published: June 2017

AbstractDuring the last several decades, the Mediterranean littoral shallow water benthic communities have suffered significant changes in their structure and taxa composition. Despite numerous studies conducted to characterize these changes at various levels, it has always been very difficult to disentangle the effects of natural factors from anthropic ones. The main purpose of this work was to evaluate possible changes, over a 10‐year scale, in diversity and abundance of the most representative species of the benthic communities considered to be primarily and potentially affected by natural stressors in a highly protected area. Sets of macro‐photographs were taken in 2002–2003 of three sites inside a small bay called Ca’ dell'Oro, which is the “no entry—no take” zone of the Marine Protected Area of Portofino, in order to analyse the structure of the benthic communities at different depths over a short time scale. The same sampling was repeated 10 years later in 2013. In the 10‐year span, a significant change in the macroalgal coverage and composition was observed, while the overall richness and coverage of species remained almost unchanged. This process resulted in a significant reduction of the habitat complexity of the three‐dimensional algal components. Likewise, a remarkable change in terms of presence and abundance occurred among all zoobenthic components. The benthic communities seem to have suffered from detrimental effects probably caused by climatic events that have been occurring in recent years in the Ligurian Sea.
A Cell‐Based Distributed‐Coordinated Approach for Network‐Level Signal Timing Optimization
Authors: Mehrabipour Mehrzad , Hajbabaie Ali 
Published: June 2017

AbstractThis article develops an efficient methodology to optimize the timing of signalized intersections in urban street networks. Our approach distributes a network‐level mixed‐integer linear program (MILP) to intersection level. This distribution significantly reduces the complexity of the MILP and makes it real‐time and scalable. We create coordination between MILPs to reduce the probability of finding locally optimal solutions. The formulation accounts for oversaturated conditions by using an appropriate objective function and explicit constraints on queue length. We develop a rolling‐horizon solution algorithm and apply it to several case‐study networks under various demand patterns. The objective function of the optimization program is to maximize intersection throughput. The comparison of the obtained solutions to an optimal solution found by a central optimization approach (whenever possible) shows a maximum of 1% gap on a number of performance measures over different conditions.