bluuebunny/crossref_metadata_2025_split huggingface dataset:
High adherence to the ‘Wise List’ treatment recommendations in Stockholm: a 15-year retrospective review of a multifaceted approach promoting rational use of medicines
Authors: Eriksen Jaran , Gustafsson Lars L , Ateva Kristina , Bastholm-Rahmner Pia , Ovesjö Marie-Louise , Jirlow Malena , Juhasz-Haverinen Maria , Lärfars Gerd , Malmström Rickard E , Wettermark Björn , Andersén-Karlsson Eva 
Published: May 2017

ObjectivesTo present the ‘Wise List’ (a formulary of essential medicines for primary and specialised care in Stockholm Healthcare Region) and assess adherence to the recommendations over a 15-year period.DesignRetrospective analysis of all prescription data in the Stockholm Healthcare Region between 2000 and 2015 in relation to the Wise List recommendations during the same time period.SettingAll outpatient care in the Stockholm Healthcare Region.ParticipantsAll prescribers in the Stockholm Healthcare Region.Main outcome measuresThe number of core and complementary substances included in the Wise List, the adherence to recommendations by Anatomic Therapeutic Chemical (ATC) 1st level using defined daily doses (DDDs) adjusted to the DDD for 2015, adherence to recommendations over time measured by dispensed prescriptions yearly between 2002 and 2015.ResultsThe number of recommended core substances was stable (175–212). Overall adherence to the recommendations for core medicines for all prescribers increased from 75% to 84% (2000 to 2015). The adherence to recommendations in primary care for core medicines increased from 80% to 90% (2005 to 2015) with decreasing range in practice variation (32% to 13%). Hospital prescriber adherence to core medicine recommendations was stable but increased for the combination core and complementary medicines from 77% to 88% (2007 to 2015). Adherence varied between the 4 therapeutic areas studied.ConclusionsHigh and increasing adherence to the Wise List recommendations was seen for all prescriber categories. The transparent process for developing recommendations involving respected experts and clinicians using strict criteria for handling potential conflicts of interests, feedback to prescribers, continuous medical education and financial incentives are possible contributing factors. High-quality evidence-based recommendations to prescribers, such as the Wise List, disseminated through a multifaceted approach, will become increasingly important and should be developed further to include recommendations and introduction protocols for new expensive medicines.
Frequency dependence of dielectric characteristics of seawater ionic solution under static magnetic field
Authors: Guo Shaoshuai , Peng Yufeng , Han Xueyun , Li Jiangting 
Published: May 2017

In order to study the electromagnetic wave transmission characteristics in seawater under external physical effects, we present a study of seawater ionic solution and perform a theoretical basis of magnetic field on water molecules and ionic motion to investigate the variation of dielectric properties with frequency under static magnetic field (0.38 T). Seawater is a naturally multi-component electrolyte solution, the main ingredients in seawater are inorganic salts, such as NaCl, MgSO4, MgCl2, CaCl2, KCl, NaHCO3, etc. The dielectric properties of these electrolyte solutions with different salinity values (0.01–5%) were measured in frequencies ranging from 40 to 5 MHz at 12[Formula: see text]C. The results show that the dielectric constant decreases with increasing frequencies no matter with magnetic field or without it. Frequency dependence of the dielectric constant of NaCl solution increases under magnetic field at measure concentrations. In a solution of MgCl2 ⋅ 6H2O, KCl and NaHCO3 are consistent with NaCl solution, while CaCl2 ⋅ 2H2O solution is in contrast with it. We also find that dielectric loss plays a major role in complex permittivity. With the effect of magnetic field, the proportion of dielectric loss is reducing in complex permittivity. On this basis it was concluded that the magnetic field influences the orientation of dipoles and the variation is different in salt aqueous solution.
Investigating the dielectric properties and low-frequency relaxation process of TlGaSe2 crystals
Authors: Samadov Oktay , Alakbarov Oktay , Najafov Arzu , Samadov Samir , Mehdiyev Nizami , Huseynov Elchin 
Published: May 2017

The dielectric and impedance spectra of TlGaSe2 crystals have been studied at temperatures in the 100–500 K range in the alternating current (AC [Formula: see text]1 V). It has been shown that the conductivity of TlGaSe2 crystals is mainly an ionic characteristic at temperatures above 400 K. The well-defined peak at the frequency dependence of the imaginary part of impedance [Formula: see text] is observed in the 215–500 K temperature range. In a constant field, there occurs a significant decrease in electrical conductivity [Formula: see text] in due course. The ionic contribution to conductivity (76% at [Formula: see text]) has been estimated from a kinetic change in electrical conductivity [Formula: see text] under the influence of a constant electric field. The diagram analysis in a complex plane [Formula: see text] has been conducted by applying the method of an equivalent circuit of the substation. It has been determined that the average relaxation time of the electric module of the sample is [Formula: see text].
Multisensory components of rapid motor responses to fingertip loading
Authors: Crevecoeur F. , Barrea A. , Libouton X. , Thonnard J.-L. , Lefèvre P. 
Published: May 2017

Tactile and muscle afferents provide critical sensory information for grasp control, yet the contribution of each sensory system during online control has not been clearly identified. More precisely, it is unknown how these two sensory systems participate in online control of digit forces following perturbations to held objects. To address this issue, we investigated motor responses in the context of fingertip loading, which parallels the impact of perturbations to held objects on finger motion and fingerpad deformation, and characterized surface recordings of intrinsic (first dorsal interosseous, FDI) and extrinsic (flexor digitorum superficialis, FDS) hand muscles based on statistical modeling. We designed a series of experiments probing the effects of peripheral stimulation with or without anesthesia of the finger, and of task instructions. Loading of the fingertip generated a motor response in FDI at ~60 ms following the perturbation onset, which was only driven by muscle stretch, as the ring-block anesthesia reduced the gain of the response occurring later than 90 ms, leaving responses occurring before this time unaffected. In contrast, the motor response in FDS was independent of the lateral motion of the finger. This response started at ~90 ms on average and was immediately adjusted to task demands. Altogether these results highlight how a rapid integration of partially distinct sensorimotor circuits supports rapid motor responses to fingertip loading. NEW & NOTEWORTHY To grasp and manipulate objects, the brain uses touch signals related to skin deformation as well as sensory information about motion of the fingers encoded in muscle spindles. Here we investigated how these two sensory systems contribute to feedback responses to perturbation applied to the fingertip. We found distinct response components, suggesting that each sensory system engages separate sensorimotor circuits with distinct functions and latencies.
Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer
Authors: Torres-Adorno Angie M. , Lee Jangsoon , Kogawa Takahiro , Ordentlich Peter , Tripathy Debu , Lim Bora , Ueno Naoto T. 
Published: May 2017

Abstract
Purpose: Inflammatory breast cancer (IBC), diagnosed clinically, and triple-negative breast cancer (TNBC), diagnosed by molecular receptor status, are the two most aggressive forms of breast cancer, and both lack effective targeted therapies. We previously demonstrated involvement of histone deacetylase (HDAC) inhibitor entinostat in regulating apoptosis in IBC and TNBC cells; here, we aimed to identify novel combination therapy candidates.
Experimental Design: Potential therapeutic targets were identified by mRNA expression profiling of TNBC and IBC cells treated with entinostat. Drug action and synergism were assessed by in vitro proliferation assays, tumor growth in vivo, and proteomic analyses. Gain/loss-of-expression studies were utilized to functionally validate the role of identified targets in sensitivity of TNBC and IBC cells to combination therapy.
Results: Entinostat induced activity of the oncogenic ERK pathway and expression of proapoptotic NOXA. These are known to stabilize and degrade, respectively, MCL1, an antiapoptotic Bcl-2 protein. In breast cancer patients, high-MCL1/low-NOXA tumor expression correlated significantly with poor survival outcomes. Combination treatment of entinostat with MEK inhibitor pimasertib reduced the growth of TNBC and IBC cells in vitro and inhibited tumor growth in vivo. The synergistic action of combination therapy was observed in TNBC and IBC cell lines in which NOXA expression was induced following entinostat treatment. The therapeutic activity depended on induction of mitochondrial cell death pathways initiated by NOXA-mediated MCL1 degradation.
Conclusions: Our preclinical findings provide a rationale for the clinical testing of combination HDAC and MEK pathway inhibition for TNBC and IBC that exhibit elevated baseline tumor MCL1 expression. Clin Cancer Res; 23(16); 4780–92. ©2017 AACR.
Electrical Conductivity of Polyaniline Fiber Synthesized by Interfacial Polymerization and Electrospinning
Authors: Ketut Umiati Ngurah Ayu , Abraha Kamsul , Triyana Kuwat 
Published: May 2017

<p align="justify">Polyaniline fiber is a promising biosensor material due to the capability of this material as an effective mediator for electron transfer. The polyaniline in fibre has wider surface to increase the electron transfer. In this work, polyaniline structure synthesized by interfacial polymerization was compared to polyaniline structure obtained from electrospinning to get a better fibre structure. Interfacial polymerization was carried out to form a polymerization between the water phase and the organic phase. The water phase was prepared from dopants, initiator and aquadestilata and the organic phase was was made from toluene as an organic solvent and aniline monomer. Electrospinning was conducted by using a dc high voltage 15 kV and 0.5 mm syringe needle to produce fibers from a melt polymer solution taken from interfacial polymerization. The scanning electro microscope results confimed the formation of polyaniline in structure of fiber. Resistance measurement by using LCR meter showed that polyaniline fiber resulted from electrospinning is more conductive than polyaniline fiber formed by interfacial polymerization method. </p><p align="justify"> </p>
Since the days of Baroness: Funarte SP Cultural Complex as a place of memory
Authors: Moreira Maria Ester Lopes , Melo Sharine Machado Cabral 
Published: May 2017

O artigo trata dos espaços ocupados atualmente pelo Complexo Cultural Funarte SP, pela Representação Regional do Ministério da Cultura e pela Fundação Biblioteca Nacional, localizados no bairro de Campos Elíseos, em São Paulo. As edificações podem ser vistas como um lugar de memória por revelarem uma parte da história da cidade e do país, principalmente no que se refere ao desenvolvimento de políticas públicas para as áreas de educação e cultura
The concept of ruin and the conservation dilemma in contemporary art
Authors: Sousa Júnior Mário Anacleto De 
Published: May 2017

Sabe-­‐se que a arte contemporânea tem se concentrado mais na tríade constituída pela figura do artista, a poética dos materiais e o mercado de arte, tornando a produção artística em produtos culturais únicos, avaliados de acordo com a demanda do novo e da necessidade de um material duradouro e inovador em relação à ideia. É cada vez menos aceitável a possibilidade de envelhecimento da obra, a tal ponto que esta pode aproximar‐se da ruína devido à impossibilidade técnica de restauração, conservação e preservação que temos atualmente à nossa disposição. A partir deste ponto propomos uma discussão sobre o conceito de ruína na arte contemporânea por meio das representações pictóricas de séculos anteriores com um olhar para a história da conservação e restauração de bens culturais até o presente. Com esta contribuição ao conceito de ruína, no que se refere à matéria como valor discursivo e estético, indagamos qual a relação, ou quais, existem entre a arte contemporânea e este conceito ante o envelhecimento, até o ponto mesmo de degradar‐se, levando inexoravelmente a uma perda irreversível com a possibilidade iminente da morte da ideia
Between remains and traces: the open history and its beginnings.	Notes	from Benjamin	and	Didi-­‐Huberman
Authors: Santos Iaci D’Assunção 
Published: May 2017

Na “história aberta”, proposta por Walter Benjamin, o linear e o cronológico seriam uma possibilidade dentre várias. O presente em que se escreve/inscreve a história imobilizaria o passado e, simultaneamente, o impregnaria, a partir do agora, de novos significados. A montagem, ideia central para Benjamin, seria uma operação que poderia ser sempre aperfeiçoada e se ligaria a esta abertura. Georges Didi-­‐Huberman segue os rastros deixados por Benjamin e explora as possibilidades de recomeço da história frente à esta abertura e nos coloca diante da imagem e de seus restos e malícias
The construction of memory as a palimpsest
Authors: Prado Carolina Vigna , Taam Pedro 
Published: May 2017

O presente artigo tem dois autores: Carolina Vigna, que vem das artes visuais e da literatura e Pedro Taam, que vem da música, da física médica e da semiótica. Propomos aqui que a memória se constrói em camadas, à maneira de um palimpsesto, e sustentamos a nossa hipótese com exemplos das artes visuais, da literatura e da música. Concluímos que a construção da memória em camadas pressupõe um conceito de tempo não-­‐linear, em que passado-presente‐futuro se sucedem, mas um modelo imbricado, em que os três são, em todos os pontos, emaranhados e indissociáveis
Who keeps always has something to reveal
Authors: Herbst Helio 
Published: May 2017

Em setembro de 1951, a imprensa brasileira noticiou a inauguração da I Bienal de São Paulo. Diversos periódicos enalteceram a magnitude do evento e sua importância para a difusão de conhecimentos. Outros, em contrapartida, questionaram a validade da iniciativa, a seleção e a premiação dos trabalhos. Algumas publicações, sensíveis aos embates então existentes entre figuração e abstração, veicularam sátiras indicativas da incompreensão dos conteúdos expostos na seção de artes. Certa dificuldade de entendimento também permeou a leitura dos projetos apresentados na Exposição Internacional de Arquitetura, especialmente em jornais e revistas de grande circulação. Levando-­‐se em conta a fortuna crítica sobre as mostras e, mais particularmente, a documentação amealhada no Arquivo Histórico Wanda Svevo da Fundação Bienal de São Paulo, o presente artigo pretende enunciar a recorrente dificuldade de aceitação ante o desconhecido. Para tanto, apresenta uma breve contextualização das Bienais, seus resultados e polêmicas, ressaltando-­‐se, para além da recepção das obras, no sentido proposto por Hans Robert Jauss, os interesses dos agentes responsáveis pela construção de uma representação oficial dos fatos, tal como propõe Roger Chartier
Empanadas with caipirinha, why not
Authors: Valansi Susana 
Published: May 2017

Reflexões sobre o conceito de cultura e seus condicionantes, tais como exílios, territórios e fronteiras. Relato autobiográfico sobre diversas situações vividas decorrentes da migração provocada pela última ditadura militar na Argentina. Indagações sobre os processos de integração regional. Uma olhada para trás, um exercício de memória
Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study
Authors: Long Michelle T. , Yin Xiaoyan , Larson Martin G. , Ellinor Patrick T. , Lubitz Steven A. , McManus David D. , Magnani Jared W. , Staerk Laila , Ko Darae , Helm Robert H. , Hoffmann Udo , Chung Raymond T. , Benjamin Emelia J. 
Published: May 2017

Background

Obesity is an important risk factor for nonalcoholic fatty liver disease and atrial fibrillation (
AF
). Less is known about the relations between nonalcoholic fatty liver disease and
AF
. We sought to evaluate the association between fatty liver and prevalent and incident
AF
in the community.

Methods and Results

We examined Framingham Heart Study participants who underwent a study‐directed computed tomography scan, had hepatic steatosis (HS) evaluated, and did not report heavy alcohol use between 2002 and 2005. We evaluated cross‐sectional associations between liver fat and prevalent
AF
with logistic regression models. We assessed the relations between liver fat and incident
AF
during 12‐year follow‐up with Cox proportional hazards models. Of 2122 participants (53% women; mean age, 59.0±9.6 years), 20% had HS.
AF
prevalence (n=62) among individuals with HS was 4% compared to 3% among those without HS. There was no significant association between HS (measured as continuous or dichotomous variables) and prevalent
AF
in age‐ and sex‐adjusted or multivariable‐adjusted models. Incidence of
AF
(n=153) among participants with and without HS was 8.7 cases and 7.8 cases per 1000 person‐years, respectively. In age‐ and sex‐adjusted and multivariable‐adjusted models, there were no significant associations between continuous or dichotomous measures of HS and incident
AF
.

Conclusions

In our community‐based, longitudinal cohort study, liver fat by computed tomography scan was not significantly associated with increased prevalence or incidence of
AF
over 12 years of follow‐up.
Randomized Trial Comparing the Effects of Ticagrelor Versus Clopidogrel on Myocardial Perfusion in Patients With Coronary Artery Disease
Authors: Pelletier‐Galarneau Matthieu , Hunter Chad R. R. N. , Ascah Kathryn J. , Beanlands Rob S. B. , Dwivedi Girish , deKemp Robert A. , Chow Benjamin J. W. , Ruddy Terrence D. 
Published: May 2017

Background

Ticagrelor is a P2Y
12
receptor inhibitor used in acute coronary syndromes to reduce platelet activity and to decrease thrombus formation. Ticagrelor is associated with a reduction in mortality incremental to that observed with clopidogrel, potentially related to its non–antiplatelet effects. Evidence from animal models indicates that ticagrelor potentiates adenosine‐induced myocardial blood flow (
MBF
) increases. We investigated
MBF
at rest and during adenosine‐induced hyperemia in patients with stable coronary artery disease treated with ticagrelor versus clopidogrel.

Methods and Results

This randomized double‐blinded crossover study included 22 patients who received therapeutic interventions of ticagrelor 90 mg orally twice a day for 10 days and clopidogrel 75 mg orally once a day for 10 days, with a washout period of at least 10 days between the treatments. Global and regional
MBF
and myocardial flow reserve were measured using rubidium 82 positron emission tomography/computed tomography at baseline and during intermediate‐ and high‐dose adenosine. Global
MBF
was significantly greater with ticagrelor versus clopidogrel (1.28±0.55 versus 1.13±0.47 mL/min per gram,
P
=0.002) at intermediate‐dose adenosine and not different at baseline (0.65±0.19 versus 0.60±0.15 mL/min per gram,
P
=0.084) and at high‐dose adenosine (1.64±0.40 versus 1.61±0.19 mL/min per gram,
P
=0.53). In regions with impaired myocardial flow reserve (<2.5),
MBF
was greater with ticagrelor compared with clopidogrel during intermediate and high doses of adenosine (
P
<0.0001), whereas the differences were not significant at baseline.

Conclusions

Ticagrelor potentiates global and regional adenosine‐induced
MBF
increases in patients with stable coronary artery disease. This effect may contribute to the incremental mortality benefit compared with clopidogrel.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
01894789.
The Role of Precipitation in Controlling the Transition from Stratocumulus to Cumulus Clouds in a Northern Hemisphere Cold-Air Outbreak
Authors: Abel Steven J. , Boutle Ian A. , Waite Kirk , Fox Stuart , Brown Philip R. A. , Cotton Richard , Lloyd Gary , Choularton Tom W. , Bower Keith N. 
Published: May 2017

Abstract
Aircraft observations in a cold-air outbreak to the north of the United Kingdom are used to examine the boundary layer and cloud properties in an overcast mixed-phase stratocumulus cloud layer and across the transition to more broken open-cellular convection. The stratocumulus cloud is primarily composed of liquid drops with small concentrations of ice particles and there is a switch to more glaciated conditions in the shallow cumulus clouds downwind. The rapid change in cloud morphology is accompanied by enhanced precipitation with secondary ice processes becoming active and greater thermodynamic gradients in the subcloud layer. The measurements also show a removal of boundary layer accumulation mode aerosols via precipitation processes across the transition that are similar to those observed in the subtropics in pockets of open cells. Simulations using a convection-permitting (1.5-km grid spacing) regional version of the Met Office Unified Model were able to reproduce many of the salient features of the cloud field although the liquid water path in the stratiform region was too low. Sensitivity studies showed that ice was too active at removing supercooled liquid water from the cloud layer and that improvements could be made by limiting the overlap between the liquid water and ice phases. Precipitation appears to be the key mechanism responsible for initiating the transition from closed- to open-cellular convection by decoupling the boundary layer and depleting liquid water from the stratiform cloud.
Calculating the Meridional Volume, Heat, and Freshwater Transports from an Observing System in the Subpolar North Atlantic: Observing System Simulation Experiment
Authors: Li Feili , Lozier M. Susan , Johns William E. 
Published: May 2017

AbstractA transbasin monitoring array from Labrador to Scotland was deployed in the summer of 2014 as part of the Overturning in the Subpolar North Atlantic Program (OSNAP). The aim of the observing system is to provide a multiyear continuous measure of the Atlantic meridional overturning circulation (AMOC) and the associated meridional heat and freshwater transports in the subpolar North Atlantic. Results from the array are expected to improve the understanding of the variability of the subpolar transports and the nature and degree of the AMOC’s latitudinal dependence. In this present work, the measurements of the OSNAP array are described and a suite of observing system simulation experiments in an eddy-permitting numerical model are used to assess how well these measurements will estimate the fluxes across the OSNAP section. The simulation experiments indicate that the OSNAP array and calculation methods will adequately capture the mean and temporal variability of the overturning circulation and of the heat and freshwater transports across the subpolar North Atlantic.