bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection
Authors: Lyden Patrick , Weymer Sara , Coffey Chris , Cudkowicz Merit , Berg Samantha , O’Brien Sarah , Fisher Marc , Haley E. Clarke , Khatri Pooja , Saver Jeff , Levine Steven , Levy Howard , Rymer Marilyn , Wechsler Lawrence , Jadhav Ashutosh , McNeil Elizabeth , Waddy Salina , Pryor Kent 
Published: November 2016

Background and Purpose—
The advent of intra-arterial neurothrombectomy (IAT) for acute ischemic stroke opens a potentially transformative opportunity to improve neuroprotection studies. Combining a putative neuroprotectant with recanalization could produce more powerful trials but could introduce heterogeneity and adverse event possibilities. We sought to demonstrate feasibility of IAT in neuroprotectant trials by defining IAT selection criteria for an ongoing neuroprotectant clinical trial.

Methods—
The study drug, 3K3A-APC, is a pleiotropic cytoprotectant and may reduce thrombolysis-associated hemorrhage. The NeuroNEXT trial NN104 (RHAPSODY) is designed to establish a maximally tolerated dose of 3K3A-APC. Each trial site provided their IAT selection criteria. An expert panel reviewed site criteria and published evidence. Finally, the trial leadership designed IAT selection criteria.

Results—

Derived selection criteria reflected consistency among the sites and comparability to published IAT trials. A protocol amendment allowing IAT (and relaxed age, National Institutes of Health Stroke Scale, and time limits) in the RHAPSODY trial was implemented on June 15, 2015. Recruitment before and after the amendment improved from 8 enrolled patients (601 screened, 1.3%) to 51 patients (821 screened, 6.2%; odds ratio [95% confidence limit] of 4.9 [2.3–10.4];
P
<0.001). Gross recruitment was 0.11 patients per site month versus 0.43 patients per site per month, respectively, before and after the amendment.

Conclusions—
It is feasible to include IAT in a neuroprotectant trial for acute ischemic stroke. Criteria are presented for including such patients in a manner that is consistent with published evidence for IAT while still preserving the ability to test the role of the putative neuroprotectant.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02222714.
On the Dynamics of the Southern Senegal Upwelling Center: Observed Variability from Synoptic to Superinertial Scales
Authors: Capet Xavier , Estrade Philippe , Machu Eric , Ndoye Siny , Grelet Jacques , Lazar Alban , Marié Louis , Dausse Denis , Brehmer Patrice 
Published: November 2016

AbstractUpwelling off southern Senegal and Gambia takes place over a wide shelf with a large area where depths are shallower than 20 m. This results in typical upwelling patterns that are distinct (e.g., more persistent in time and aligned alongshore) from those of other better known systems, including Oregon and Peru where inner shelves are comparatively narrow. Synoptic to superinertial variability of this upwelling center is captured through a 4-week intensive field campaign, representing the most comprehensive measurements of this region to date. The influence of mesoscale activity extends across the shelf break and far over the shelf where it impacts the midshelf upwelling (e.g., strength of the upwelling front and circulation), possibly in concert with wind fluctuations. Internal tides and solitary waves of large amplitude are ubiquitous over the shelf. The observations suggest that these and possibly other sources of mixing play a major role in the overall system dynamics through their impact upon the general shelf thermohaline structure, in particular in the vicinity of the upwelling zone. Systematic alongshore variability in thermohaline properties highlights important limitations of the 2D idealization framework that is frequently used in coastal upwelling studies.
Effect of Botulinum Toxin and Surgery among Spasmodic Dysphonia Patients: A Systematic Review
Authors: van Esch Babette F. , Wegner Inge , Stegeman Inge , Grolman Wilko 
Published: November 2016

ObjectiveThe effect of botulinum toxin among patients with adductor spasmodic dysphonia (AdSD) is temporary. To optimize long‐term treatment outcome, other therapy options should be evaluated. Alternative treatment options for AdSD comprise several surgical treatments, such as thyroarytenoid myotomy, thyroplasty, selective laryngeal adductor denervation‐reinnervation, laryngeal nerve crush, and recurrent laryngeal nerve resection. Here, we present the first systematic review comparing the effect of botulinum toxin with surgical treatment among patients diagnosed with AdSD.Data SourcesMEDLINE (PubMed), EMBASE, and the Cochrane Library.MethodsArticles were reviewed by 2 independent authors, and data were compiled in tables for analysis of the objective outcome (voice expert evaluation after voice recording), the subjective outcome (patient self‐assessment scores), and voice‐related quality of life (Voice Health Index scores).ResultsNo clinical trials comparing both treatment modalities were identified. Single‐armed studies evaluated either the effect of botulinum toxin or surgical treatment. Thirteen studies reported outcomes after botulinum toxin treatment (n = 419), and 9 studies reported outcomes after surgical treatment (n = 585 patients). A positive effect of bilateral botulinum toxin injections was found for the objective voice outcome, subjective voice outcome, and quality of life. The duration of the beneficial effect ranged from 15 to 18 weeks. Surgical treatment had an overall positive effect on objective voice improvement, subjective voice improvement, and quality of live.ConclusionNo preference for one treatment could be demonstrated. Prospective clinical trials comparing treatment modalities are recommended to delineate the optimal outcomes by direct comparison.
The Role of Helicobacter pylori in Laryngopharyngeal Reflux: A Systematic Review and Meta‐analysis
Authors: Campbell Ross , Kilty Shaun J. , Hutton Brian , Bonaparte James P. 
Published: November 2016

ObjectiveThe primary objective was to determine the prevalence of Helicobacter pylori among patients with laryngopharyngeal reflux. The secondary objective was determining if H pylori eradication leads to greater symptom improvement in patients with laryngopharyngeal reflux as compared with standard proton pump inhibitor therapy alone.Data SourcesEMBASE, Cumulative Index to Nursing and Allied Health Literature, MEDLINE, World Health Organization International Clinical Trials Registry Platform, European Union Clinical Trials Register, Cochrane Library databases of clinical trials, and ClinicalTrials.gov.Review MethodsA systematic review was performed of studies assessing the diagnosis or treatment of H pylori among patients with laryngopharyngeal reflux. Randomized controlled trials, cohort studies, case‐control studies, and case series were included. A meta‐analysis of prevalence data and assessment of heterogeneity was performed on relevant studies.ResultsFourteen studies were analyzed in the review, with 13 eligible for the meta‐analysis. We determined that the prevalence of H pylori among patients with laryngopharyngeal reflux was 43.9% (95% confidence interval, 32.1‐56.5). The heterogeneity of studies was high, with an overall I
2 value of 92.3%. We were unable to quantitatively assess findings for our secondary outcome, since H pylori identification and treatment were not the primary focus of the majority of studies.ConclusionThere is a high rate of H pylori infection among patients with laryngopharyngeal reflux. The infection rate in North America and Western Europe has not been adequately studied. There is insufficient evidence to make a recommendation regarding the testing and treatment of H pylori infection among patients with laryngopharyngeal reflux.
Cross-Sectional Assessment of Orthopedic Foot and Ankle Patient Knowledge
Authors: Rosenbaum Andrew J. , Marinescu Anca Gabriela , Levine David , Ellis Scott J. 
Published: November 2016

Background: Individuals with limited health literacy often struggle in effectively communicating with their physicians and may lack the skills needed to make informed health decisions. It is therefore important that providers have insight into patients’ baseline medical knowledge, as this can help physicians customize their approach to, and conversations with, each patient. As such, this study evaluated the foot and ankle–specific knowledge of patients seeking care for various foot and ankle ailments. Methods: An unvalidated survey developed by our study group was distributed to 206 patients, assessing their knowledge of foot and ankle anatomy, terminology, conditions, treatment, and perioperative issues. Performance was evaluated as a function of participants’ demographic factors. Results: Participants performed significantly worse on the conditions and treatment questions as compared to the anatomy, terminology, and perioperative considerations subsections. Significantly better performance correlated with education (≥college), visit type (preoperative evaluation), a current or previous health care occupation, and prior orthopedic surgeon evaluation. Conclusions: Patients’ knowledge of foot and ankle anatomy, terminology, conditions, treatment, and perioperative issues correlates with certain patient characteristics and demographics. With enhanced insight into the risk factors for limited knowledge, education campaigns can be designed to target those most in need.
Collective strategy for obstacle navigation during cooperative transport by ants
Authors: McCreery Helen F. , Dix Zachary A. , Breed Michael D. , Nagpal Radhika 
Published: November 2016

ABSTRACT
Group cohesion and consensus have primarily been studied in the context of discrete decisions, but some group tasks require making serial decisions that build on one another. We examine such collective problem solving by studying obstacle navigation during cooperative transport in ants. In cooperative transport, ants work together to move a large object back to their nest. We blocked cooperative transport groups of Paratrechina longicornis with obstacles of varying complexity, analyzing groups' trajectories to infer what kind of strategy the ants employed. Simple strategies require little information, but more challenging, robust strategies succeed with a wider range of obstacles. We found that transport groups use a stochastic strategy that leads to efficient navigation around simple obstacles, and still succeeds at difficult obstacles. While groups navigating obstacles preferentially move directly toward the nest, they change their behavior over time; the longer the ants are obstructed, the more likely they are to move away from the nest. This increases the chance of finding a path around the obstacle. Groups rapidly changed directions and rarely stalled during navigation, indicating that these ants maintain consensus even when the nest direction is blocked. Although some decisions were aided by the arrival of new ants, at many key points, direction changes were initiated within the group, with no apparent external cause. This ant species is highly effective at navigating complex environments, and implements a flexible strategy that works for both simple and more complex obstacles.
Contexto de Vida de Adolescentes em Período de Reclusão
Authors: Silva Inez Maria De Jesus , Melo Rosana Alves de , Dos Santos Nadja Maria 
Published: November 2016

Objetivo: Analisar o contexto para a ocorrência do ato infracional por parte dos adolescentes internados em uma instituição de Atendimento Socioeducativo no município de Petrolina-PE. Método: Estudo descritivo, de abordagem qualitativa, realizada com quinze adolescentes em período de reclusão na Fundação de Atendimento Socioeducativo, no período de janeiro e fevereiro de 2015, através de entrevista semiestruturada. Os dados foram analisados pelo método de análise de conteúdo temática. Resultados: Diversos fatores como ausência escolar, baixo nível socioeconômico, falta de estrutura familiar e vivência de violência em casa e na rua, foram fatores determinantes para a prática de ato infracional. Conclusão: As medidas socioeducativas, o apoio social e o suporte familiar, mesmo no período de reclusão, são fatores cruciais para a ressocialização dos adolescentes infratores. Assim, as fundações socioeducativas necessitam possuir estrutura adequada e equipe multiprofissional humanizada para favorecer um atendimento integral e re-socializador.
Síndrome Alcoólica Fetal: Uma abordagem reflexiva da Psicopedagogia no contexto da Educação Básica
Authors: Silva Henrique Miguel de Lima , Cabral Symara Abrantes Albuquerque de Oliveira , Alencar Maria Carmem Batista de , Alves Segundo Edgley Gonçalves , Silva Edvânia Maria Leite 
Published: November 2016

O presente trabalho propõe-se a partir da abordagem sociointeracionista de autores como Piaget (1979), Vygotsky (1989), dentre outros, que partilham da análise do indivíduo na perspectiva dialógica, inserir dentro da educação básica a temática da síndrome alcoólica fetal com base em práticas reflexivas, no intuito de promover um desenvolvimento crítico do educandos acerca das relações entre álcool e desenvolvimento cognitivo humano. Trata-se de um relato de experiência de atividade formativa realizada com docentes do ensino fundamental, com abordagem da temática, de modo a provocar a reflexão para prática. Dessa maneira, buscar compreender os modos de interação na sociedade contemporânea propicia a construção de métodos e pesquisas que possam explorar o comportamento humano e, por conseguinte, desenvolver as relações sociais como um todo, tomando por base a observação de ação realizada.
Inhibition of GSK‐3β increases trabecular bone volume but not cortical bone volume in adenine‐induced uremic mice with severe hyperparathyroidism
Authors: Tatsumoto Narihito , Arioka Masaki , Yamada Shunsuke , Takahashi‐Yanaga Fumi , Tokumoto Masanori , Tsuruya Kazuhiko , Kitazono Takanari , Sasaguri Toshiyuki 
Published: November 2016

AbstractPatients with chronic kidney disease (CKD) are at increased risk for bone fractures compared with the general population. Repression of the Wnt/β‐catenin signaling pathway is associated with bone abnormalities. Inhibition of glycogen synthase kinase (GSK)‐3β, a critical component of the Wnt/β‐catenin signaling pathway, increases bone volume through accumulation of β‐catenin. It remains unknown whether inhibition of GSK‐3β increases bone volume in CKD. The present in vivo study examined the effects of GSK‐3β inhibition on bone volume in CKD mice. Wild‐type mice were divided into three groups. One group was fed a control diet (CNT) and the other two groups were fed a diet containing 0.2% adenine and given water with or without lithium chloride (LiCl), a GSK‐3 inhibitor (CKD, CKD+LiCl, respectively). GSK‐3β heterozygous knockout mice were fed a diet containing 0.2% adenine (CKD‐GSK‐3β+/−). After 6 weeks, trabecular and cortical bone volumes of the femur were analyzed using microcomputed tomography. CKD mice developed azotemia, hyperphosphatemia, and hyperparathyroidism, followed by a decrease in cortical bone volume without any change in trabecular bone volume. Serum levels of urea nitrogen, phosphate, and parathyroid hormone were comparable among the three groups of CKD mice. Trabecular bone volume increased in CKD‐GSK‐3β+/− and CKD+LiCl mice compared with CNT and CKD mice. However, there were no significant differences in cortical bone volume among the three groups of CKD mice. The results suggest that inhibition of GSK‐3β increases trabecular bone volume but not cortical bone volume in adenine‐induced uremic mice with uncontrolled hyperparathyroidism.
Artificial Insemination of Carpathian Goats with Semen Preserved in Different Forms
Authors: Andreea Anghel , Nadolu Dorina , Claudiu Anghelescu , Cristinel Sonea 
Published: November 2016

Abstract
The artificial insemination (AI) technique is an essential tool in goat breeding programs, since it increases the efficiency of sire genetic evaluation and the extension of genetic improvements; at the same time, it enables control of parturition dates with a view to meeting market demands. The objective of this study was to determine the fecundity rate according to the mode of semen preservation before artificial insemination. The percentage of kidding was influenced by the duration of storage: 3 h = 88%; 14 h =821%.
Bioeconomic Significance to Diversify the Production in Romanian Agriculture District
Authors: Sandu Mariana , Moise Virgil 
Published: November 2016

Abstract
Agricultural diversification is an important mechanism for economic growth. With the globalization of markets, diversification of agriculture has as result the increasing crop productivity in terms of quality, quantity and monetary value.
The purpose of this paper is to give an overview of Romanian agriculture in terms of diversifying production. Based on the National Statistics Institute, it analyzes the dynamics of vegetable and animal sector in terms of cultivated areas, livestock, the total and average production obtained.
Romanian agriculture is at a disadvantage due to excessive fragmentation of ownership, low use of agricultural land through cultivation or weak endowment with agricultural machinery and lack of organization.
We conclude that agriculture as a whole, had not a positive development. Fluctuations in the main indicators of production are the consequences of the long transition period and of the incoherent policies on agriculture in general and to each sector, in particular.
The Use of Breeding Biotechnologies in Romanian Livestock
Authors: Sandu Mariana , Mantea Stefan 
Published: November 2016

Abstract
For livestock holdings, the breeding sector is the most important and the level of breeding technical indicators is the path to profit or loss. It can be said that in animal husbandry, this is the sector with the highest degree of technicality and that is why there were made efforts in research to create modern techniques that allow the man to control all these phenomena and the level of indicators to not depend only on the capabilities of the bull, boar, ram and rooster, etc.
The aim of this paper is to provide a view upon the use of breeding biotechnologies in Romanian livestock. Based on the data of National Agency for Improvement and Reproduction in Animal Husbandry were analyzed the dynamics of artificial insemination, in species of livestock contained in Official Control of Production (COP). The dynamics of embryo transfer in cattle, in Romania, in the period 2000-2012 is based on data reported by the Romanian Association of Embryo Transfer (A.R.E.T.) to the European Association of Embryo Transfer (A.E.T.E.).
Although until 1990 agricultural research and the system of state enterprises favored the application of these biotechnologies, after 1990, the highly divided property in agriculture and the lack of organization of farmers in associative forms resulted in the restricted use of these modern techniques.
Regarding the use A.I., in the analyzed period, the total number of A.I. decreased by 55%, due to the changes that have occurred since 1990, with the restructuring that occurred in livestock (reducing the number of large farms and the continue decline of the number of females) and in the national network of breeding and selection of animals.
In Romania, due to high costs, embryo transfer is not a method currently used and accessible to ordinary farmers, being used mostly to obtain the bulls used in artificial insemination network or the cows as steers mothers.
Analysis of Groundwater Qualitative Parameters in the Hill and Plain Sector of Dambovita County – Romania
Authors: Nitu Iulia , Murarescu Ovidiu , Muratoreanu George , Frinculeasa Madalina , Cosac Aurelia Corina 
Published: November 2016

Abstract
Water intended for human consumption (whether natural or after applying appropriate treatment techniques) must comply with the values of quality parameters according to the laws and regulations in force. The geographical area analysed in this study covers part of Dambovita County and lies at the contact between the Outer Subcarpathian Hills at the Curvature and Candesti Piedmont, the High Plain of Targoviste and Titu Subsidence Plain. Considering that the population in this area is also supplied with water from individual wells, which capture surface aquifers, changes in some potability parameters may appear punctually, inducing a number of health impairments if consumed over a long period of time. 12 sample points have been chosen in localities considered to be vulnerable and a number of parameters (pH, Ca2+, Cl-) have been analysed in the laboratory. Analyses have revealed excessive MAC (Maximum Allowable Concentration) in some locations such as Glodeni and Gheboaia.
The Influence of Some Climatic Conditions for Quality Production of Winter Wheat
Authors: Nitu Iulia 
Published: November 2016

Abstract
The cereales are very important for human consumption and for animal feed too. From this point of view, over the time, it aimed to diversify the assortment varieties, in special for winter wheat. The main objectives for the research project were the analysis of bakery quality potential for winter wheat varieties cultivated in Oltenia Plain according with evolution of climatic conditions.
Die deutschsprachigen Marginaltexte der Grazer Handschrift UB, Ms. 781 als interdisziplinärer Prüfstein explorativer Revisionsforschung und Editionstechnik
Authors: Hofmeister Wernfried , Böhm Astrid , Klug Helmut W. 
Published: November 2016

Abstract
This paper tests a typology for text revisions that has been developed in collaboration with Andrea Hofmeister-Winter (cf. preceding paper) against a practical example: the manuscript Graz, UB, Ms. 781. The implied scenario is a genetic online presentation of the German marginal texts Konrad’s of Heimesfurt hinvart, Seckauer Brautwerbungsspruch, Seckauer Margaretenlegende, and Seckauer Marienleben. The texts, which are heterogeneously edited, have not yet been studied in regard to text revisions. For this project, they were transcribed according to the Graz dynamic editing method and an evaluation of this base text indicates that a digital representation of the texts and revisions would be the best means for answering text-genetic research questions. The basis for this is a TEI-XML model of the source texts that incorporates the typology for text revisions.
Bytes, Books and Readers
Authors: Rasmussen Krista Stinne Greve 
Published: November 2016

Abstract
In diesem Beitrag werden Ergebnisse aus der Dissertation der Autorin Bytes, Books, and Readers. A Historical Analysis of the Transition from Printed to Digital Scholarly Editions Focusing on ‘The Writings of Søren Kierkegaard’ (2015) vorgestellt. Dabei wird dem Wechselverhältnis zwischen der Geschichte von Editionen und der Entwicklung der Digital Humanities besonderes Augenmerk geschenkt, um zu demonstrieren, wie bedeutsam die Analyse der Überlieferung und der Textbegriff für die Geschichte von Editionen sind. Beispiele aus Alastair McKinnons erster digitaler Edition von Soren Kierkegaards Samlede Værker machen anschaulich, wie notwendig es ist, auch die Geschichte digitaler Editionen zu schreiben.