bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Three‐Dimensional Copper(II) 1,2‐Ethylenediphosphonate Framework with Channel‐like Voids
Authors: Köferstein Roberto , Arnold Michael , Robl Christian 
Published: September 2016

AbstractTurquoise monoclinic single crystals of the novel three‐dimensional Cu2[μ8‐O3P(CH2)2PO3]·3.2H2O coordination polymer were prepared using the silica gel method. Space group C2/m (no. 12) with a = 1483.6(2), b = 668.44(8), c = 436.30(6) pm, β = 93.28(2)°. The Cu2+ cation is coordinated by four oxygen atoms stemming from the 1,2‐ethylenediphosphonate dianions in a square planar manner and two water molecules in the axial positions. The connection between the Cu2+ cations and the [CPO3] units from the 1,2‐ethylenediphosphonate dianions leads to layers parallel to (100), which are linked by the ethylene groups to a three‐dimensional framework with channel‐like voids. The channel‐like voids accommodate water molecules not bound to Cu2+ and extend parallel to [001] with an opening of about 550 pm × 260 pm. Magnetic measurements reveal an antiferromagnetic behavior due to a superexchange coupling between Cu2+ ions through an oxygen bridge. The UV/Vis spectrum reveals three d–d transition bands at 694, 774, and 918 nm. The compound can be fully dehydrated by thermal treatment and rehydrated by storage in ambient air.
Numerical determination of the mechanical stiffness of a force measurement device based on capacitive probes: Application to roller bearings
Authors: Bogard Fabien , Murer Sébastien , Rasolofondraibe Lanto , Pottier Bernard 
Published: September 2016

Abstract
Bearings allow external loadings to be transferred from one raceway to the other through rolling elements, which induces strains in the bearing constituents. In order to measure the radial component of these forces, the fixed ring is inserted within a housing equipped with capacitive probes able to measure displacements with very high sensitivity. This work mainly focuses on determining the optimal housing shape using FE simulations and their influence on the global stress state undergone by the structure. Finally, an averaged global stiffness is computed, allowing proper calculation of the contact forces involved in the bearing.
Highlights The principle of capacitive measurement is explained. We model the upper half of the bearing placed in a housing in which grooves for the capacitive probes have been machined. Numerical results in terms of stress field due to probe housings presence and fillets on this housing are explained. FE simulations allow computation of local mechanical stiffness and transmitted radial forces. Very good agreement is obtained between recomputed roller-wise radial force and that directly extracted from the FE results.
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
Authors: Thomas Margaret Lois , de Antueno Roberto , Coyle Krysta Mila , Sultan Mohammad , Cruickshank Brianne Marie , Giacomantonio Michael Anthony , Giacomantonio Carman Anthony , Duncan Roy , Marcato Paola 
Published: September 2016

Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker, ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a key role in the progression and chemotherapy resistance of cancer. Therefore, ALDH1A3 represents a druggable anti‐cancer target of interest. Since to date, there are no characterized ALDH1A3 isoform inhibitors, drugs that were previously described as inhibiting the activity of other ALDH isoforms were tested for anti‐ALDH1A3 activity. Twelve drugs (3‐hydroxy‐dl‐kynurenine, benomyl, citral, chloral hydrate, cyanamide, daidzin, DEAB, disulfiram, gossypol, kynurenic acid, molinate, and pargyline) were compared for their efficacy in inducing apoptosis and reducing ALDH1A3, ALDH1A1 and ALDH2‐associated Aldefluor fluorescence in breast cancer cells. Citral was identified as the best inhibitor of ALDH1A3, reducing the Aldefluor fluorescence in breast cancer cell lines and in a patient‐derived tumor xenograft. Nanoparticle encapsulated citral specifically reduced the enhanced tumor growth of MDA‐MB‐231 cells overexpressing ALDH1A3. To determine the potential mechanisms of citral‐mediated tumor growth inhibition, we performed cell proliferation, clonogenic, and gene expression assays. Citral reduced ALDH1A3‐mediated colony formation and expression of ALDH1A3‐inducible genes. In conclusion, citral is an effective ALDH1A3 inhibitor and is able to block ALDH1A3‐mediated breast tumor growth, potentially via blocking its colony forming and gene expression regulation activity. The promise of ALDH1A3 inhibitors as adjuvant therapies for patients with tumors that have a large population of high‐ALDH1A3 CSCs is discussed.
Is it costly to be both shariah compliant and socially responsible?
Authors: Erragragui Elias , Revelli Christophe 
Published: September 2016

AbstractPositive ethics associated with socially responsible investments (SRI) is challenging the limits of Islamic investments' conservative approach to promote corporate social responsibility. In this study, we test the integration of social performance measures (companies the most virtuous or high‐rated in terms of environmental, social, and governance (ESG) issues) in Islamic portfolios using KLD social ratings. We seek to determine the financial price of complying both to Islamic investment and SRI principles. To do so, we measure the financial performance of self‐composed Islamic portfolios with varying ESG scores. The results indicate no adverse effects on returns due to the application of ESG screens on shariah‐compliant stocks during the 2007–2011 periods while reporting substantially higher performance for the portfolios with good records in governance, products, diversity, and environment issues. On the opposite, a negative performance is associated with an SRI strategy of disengagement from shariah‐compliant stocks with community and human rights controversies. Our performance measures are controlled for market sensitivity, investment style, momentum factor, and sector exposure.
Thermoregulation During Extended Exercise in the Heat: Comparisons of Fluid Volume and Temperature
Authors: Hailes Walter S. , Cuddy John S. , Cochrane Kyle , Ruby Brent C. 
Published: September 2016

Objective This study aimed to determine the physiological and thermoregulatory responses of individuals exercising in the heat (US military red flag conditions, wet-bulb globe temperature 31.5–32.2°C) while consuming varied volumes of ambient temperature water and ice slurry. Methods Participants (N = 12) walked on a treadmill for 3 hours at approximately 40% peak aerobic capacity in a hot environment while consuming ambient temperature (35.5°C) water (W), ice slurry (0°C, two-thirds shaved ice and one-third water) at a ratio of 2 g·kg-1 body mass every 10 minutes (FS), and reduced volume ice slurry as described at a rate of 1 g·kg-1 body mass every 10 minutes (HS). Trials were completed at least 14 days apart, in a randomized, repeated measures design. Results Percent body weight loss was higher during the HS trial (1.8 ± 0.01%) compared with FS (0.5 ± 0.01%; P < .001) and W (0.6 ± 0.01%; P < .001). Mean rectal temperature at 3 hours was lower during FS (37.8 ± 0.7°C) compared with HS (38.1 ± 0.8°C) and W (38.2 ± 0.8°C) ( P = .04 vs HS, and P = .005 vs W, main effect for trial). No differences were found in rectal temperature between HS and W. Heart rate was lower at the end of the third hour during FS (141 ± 10 beats/min) compared with HS (157 ± 19 beats/min) and W (154 ± 18 beats/min) ( P = .001 and P = .007, respectively, time × trial interaction). There were no differences in heart rate between HS and W. Conclusions The temperature of consumed fluids may be as important as the volume for the management of thermoregulation and other physiological responses for extended work in hot environments.
Quantum entanglement: facts and fiction – how wrong was Einstein after all?
Authors: Nordén Bengt 
Published: September 2016

AbstractEinstein was wrong with his 1927 Solvay Conference claim that quantum mechanics is incomplete and incapable of describing diffraction of single particles. However, the Einstein-Podolsky-Rosen paradox of entangled pairs of particles remains lurking with its ‘spooky action at a distance’. In molecules quantum entanglement can be viewed as basis of both chemical bonding and excitonic states. The latter are important in many biophysical contexts and involve coupling between subsystems in which virtual excitations lead to eigenstates of the total Hamiltonian, but not for the separate subsystems. The author questions whether atomic or photonic systems may be probed to prove that particles or photons may stay entangled over large distances and display the immediate communication with each other that so concerned Einstein. A dissociating hydrogen molecule is taken as a model of a zero-spin entangled system whose angular momenta are in principle possible to probe for this purpose. In practice, however, spins randomize as a result of interactions with surrounding fields and matter. Similarly, no experiment seems yet to provide unambiguous evidence of remaining entanglement between single photons at large separations in absence of mutual interaction, or about immediate (superluminal) communication. This forces us to reflect again on what Einstein really had in mind with the paradox, viz. a probabilistic interpretation of a wave function for anensembleof identically prepared states, rather than as a statement about single particles. Such a prepared state of many particles would lack properties of quantum entanglement that make it so special, including the uncertainty upon which safe quantum communication is assumed to rest. An example is Zewail's experiment showing visible resonance in the dissociation of a coherently vibrating ensemble of NaI molecules apparently violating the uncertainty principle. Einstein was wrong about diffracting single photons where space-like anti-bunching observations have proven recently their non-local character and how observation in one point can remotely affect the outcome in other points. By contrast, long range photon entanglement with immediate, superluminal response is still an elusive, possibly partly misunderstood issue. The author proposes that photons may entangle over large distances only if some interaction exists via fields that cannot propagate faster than the speed of light. An experiment to settle this ‘interaction hypothesis’is suggested.
Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction
Authors: Wasilewski Melissa A. , Grisanti Laurel A. , Song Jianliang , Carter Rhonda L. , Repas Ashley A. , Myers Valerie D. , Gao Erhe , Koch Walter J. , Cheung Joseph Y. , Feldman Arthur M. , Tilley Douglas G. 
Published: September 2016

Vasopressin type 1A receptor (V1AR) expression is elevated in chronic human heart failure (HF) and contributes to cardiac dysfunction in animal models, in part via reduced β-adrenergic receptor (βAR) responsiveness. Although cardiac V1AR overexpression and V1AR stimulation are each sufficient to decrease βAR activity, it is unknown whether V1AR inhibition conversely augments βAR responsiveness. Further, although V1AR has been shown to contribute to chronic progression of HF, its impact on cardiac function following acute ischaemic injury has not been reported. Using V1AR knockout (V1AR KO) mice we assessed the impact of V1AR deletion on cardiac contractility at baseline and following ischaemic injury, βAR sensitivity and cardiomyocyte responsiveness to βAR stimulation. Strikingly, baseline cardiac contractility was enhanced in V1AR KO mice and they experienced a greater loss in contractile function than control mice following acute ischaemic injury, although the absolute levels of cardiac dysfunction and survival rates did not differ. Enhanced cardiac contractility in V1AR KO mice was associated with augmented β-blocker sensitivity, suggesting increased basal βAR activity, and indeed levels of left ventricular cAMP, as well as phospholamban (PLB) and cardiac troponin I (cTnI) phosphorylation were elevated compared with control mice. At the cellular level, myocytes isolated from V1AR KO mice demonstrated increased responsiveness to βAR stimulation consistent with the finding that acute pharmacological V1AR inhibition enhanced βAR-mediated contractility in control myocytes. Therefore, although V1AR deletion does not protect the heart from the rapid development of cardiac dysfunction following acute ischaemic injury, its effects on βAR activity suggest that acute V1AR inhibition could be utilized to promote myocyte contractile performance.
Metamizole for Postoperative Pain Therapy in Infants Younger than 1 Year
Authors: Fieler Melanie , Eich Christoph , Becke Karin , Badelt Gregor , Leimkühler Klaus , Dennhardt Nils , Sümpelmann Robert 
Published: September 2016

Background Due to possible serious adverse drug reactions (ADRs), the use of metamizole for postoperative pain therapy in infants is a subject of debate. Safety studies with large sample sizes are missing.
Aim This prospective multicenter observational study was conducted to evaluate the use of metamizole in infants younger than 1 year undergoing surgery with a particular focus on possible serious ADRs (e.g., hemodynamic, anaphylactic or respiratory reactions, and agranulocytosis).
Methods Infants aged up to 1 year (American Society of Anesthesiologists [ASA] I–III) receiving a single dose of metamizole for postoperative pain therapy were enrolled. Patient demographics, main and secondary diagnosis, surgical procedures performed, metamizole dose, hemodynamic data, use of other analgesics and regional blocks, results of pain measurement, and incidence of ADRs were documented using a standardized case report form.
Results A total of 316 infants observed at five pediatric centers were included for analysis (age 4.4 ± 3.7 [0.06–12] months). Mean metamizole dose was 17.8 ± 3.1 (9.2–29.8) mg·kg−1. Mean arterial pressure (MAP) remained stable during metamizole infusion (MAP before infusion 45 ± 9.5 [25–95] and after infusion 45 ± 9.2 [25–99] mm Hg). Erythema was observed in one patient (ADRs total: 0.3%, 95% confidence interval: 0.27–0.32). No respiratory adverse events directly related to the metamizole administration and no clinical signs of agranulocytosis were reported.
Conclusion Single intravenous doses of metamizole used for prevention or treatment of postoperative pain were safe in more than 300 infants younger than 1 year. The statistical probability of serious ADRs (e.g., hemodynamic, anaphylactic or respiratory reactions) was lower than 1%. The sample size and follow-up were not sufficient to detect agranulocytosis.
A Physician's Reflection on the Moral Use of Human Papilloma virus Vaccine
Authors: Burke Greg F. 
Published: September 2016

Controversies often surround the use of vaccines, particularly among the pediatric population. Often, the possible temporal relationship between vaccination and subsequent disease is at the center of the controversy. However, others have questioned the moral status of the human papilloma virus (HPV) vaccine because of some instances of state coercion and also the possibility that the vaccine may promote promiscuity. This article addresses the moral status of the HPV vaccine from the perspective of a primary care physician and father of four daughters. Lay Summary: Parents are often asked by pediatricians for permission to vaccinate their children under the age of consent against the sexually transmitted virus HPV. This article addresses the medical and moral concerns about vaccination with some guiding principles to assist in a final decision.
Influence of Sex Steroid Hormones on the Adolescent Brain and Behavior: An Update
Authors: Vigil Pilar , del Río Juan Pablo , Carrera Bárbara , Aránguiz Florencia C. , Rioseco Hernán , Cortés Manuel E. 
Published: September 2016

This review explains the main effects exerted by sex steroids and other hormones on the adolescent brain. During the transition from puberty to adolescence, these hormones participate in the organizational phenomena that structurally shape some brain circuits. In adulthood, this will propitiate some specific behavior as responses to the hormones now activating those neural circuits. Adolescence is, then, a critical “organizational window” for the brain to develop adequately, since steroid hormones perform important functions at this stage. For this reason, the adolescent years are very important for future behaviors in human beings. Changes that occur or fail to occur during adolescence will determine behaviors for the rest of one's lifetime. Consequently, understanding the link between adolescent behavior and brain development as influenced by sex steroids and other hormones and compounds is very important in order to interpret various psycho-affective pathologies. Lay Summary: The effect of steroid hormones on the development of the adolescent brain, and therefore, on adolescent behavior, is noticeable. This review presents their main activational and organizational effects. During the transition from puberty to adolescence, organizational phenomena triggered by steroids structurally affect the remodeling of brain circuits. Later in adulthood, these changes will be reflected in behavioral responses to such hormones. Adolescence can then be seen as a fundamental “organizational window” during which sex steroids and other hormones and compounds play relevant roles. The understanding of the relationship between adolescent behavior and the way hormones influence brain development help understand some psychological disorders.
Precrec: fast and accurate precision–recall and ROC curve calculations in R
Authors: Saito Takaya , Rehmsmeier Marc 
Published: September 2016

Abstract

Summary
The precision–recall plot is more informative than the ROC plot when evaluating classifiers on imbalanced datasets, but fast and accurate curve calculation tools for precision–recall plots are currently not available. We have developed Precrec, an R library that aims to overcome this limitation of the plot. Our tool provides fast and accurate precision–recall calculations together with multiple functionalities that work efficiently under different conditions.

Availability and Implementation
Precrec is licensed under GPL-3 and freely available from CRAN (https://cran.r-project.org/package=precrec). It is implemented in R with C ++.

Supplementary information
Supplementary data are available at Bioinformatics online.
Leveraging electronic health record documentation for Failure Mode and Effects Analysis team identification
Authors: Kricke Gayle Shier , Carson Matthew B , Lee Young Ji , Benacka Corrine , Mutharasan R. Kannan , Ahmad Faraz S , Kansal Preeti , Yancy Clyde W , Anderson Allen S , Soulakis Nicholas D 
Published: September 2016

Objective: Using Failure Mode and Effects Analysis (FMEA) as an example quality improvement approach, our objective was to evaluate whether secondary use of orders, forms, and notes recorded by the electronic health record (EHR) during daily practice can enhance the accuracy of process maps used to guide improvement. We examined discrepancies between expected and observed activities and individuals involved in a high-risk process and devised diagnostic measures for understanding discrepancies that may be used to inform quality improvement planning.Methods: Inpatient cardiology unit staff developed a process map of discharge from the unit. We matched activities and providers identified on the process map to EHR data. Using four diagnostic measures, we analyzed discrepancies between expectation and observation.Results: EHR data showed that 35% of activities were completed by unexpected providers, including providers from 12 categories not identified as part of the discharge workflow. The EHR also revealed sub-components of process activities not identified on the process map. Additional information from the EHR was used to revise the process map and show differences between expectation and observation.Conclusion: Findings suggest EHR data may reveal gaps in process maps used for quality improvement and identify characteristics about workflow activities that can identify perspectives for inclusion in an FMEA. Organizations with access to EHR data may be able to leverage clinical documentation to enhance process maps used for quality improvement. While focused on FMEA protocols, findings from this study may be applicable to other quality activities that require process maps.
iCONCUR: informed consent for clinical data and bio-sample use for research
Authors: Kim Hyeoneui , Bell Elizabeth , Kim Jihoon , Sitapati Amy , Ramsdell Joe , Farcas Claudiu , Friedman Dexter , Feupe Stephanie Feudjio , Ohno-Machado Lucila 
Published: September 2016

Background: Implementation of patient preferences for use of electronic health records for research has been traditionally limited to identifiable data. Tiered e-consent for use of de-identified data has traditionally been deemed unnecessary or impractical for implementation in clinical settings.
Methods: We developed a web-based tiered informed consent tool called informed consent for clinical data and bio-sample use for research (iCONCUR) that honors granular patient preferences for use of electronic health record data in research. We piloted this tool in 4 outpatient clinics of an academic medical center.
Results: Of patients offered access to iCONCUR, 394 agreed to participate in this study, among whom 126 patients accessed the website to modify their records according to data category and data recipient. The majority consented to share most of their data and specimens with researchers. Willingness to share was greater among participants from an Human Immunodeficiency Virus (HIV) clinic than those from internal medicine clinics. The number of items declined was higher for for-profit institution recipients. Overall, participants were most willing to share demographics and body measurements and least willing to share family history and financial data. Participants indicated that having granular choices for data sharing was appropriate, and that they liked being informed about who was using their data for what purposes, as well as about outcomes of the research.
Conclusion: This study suggests that a tiered electronic informed consent system is a workable solution that respects patient preferences, increases satisfaction, and does not significantly affect participation in research.
Clofazimine Enteropathy: A Rare and Underrecognized Complication of Mycobacterial Therapy
Authors: Szeto Winnie , Garcia-Buitrago Monica T. , Abbo Lilian , Rosenblatt Joseph D. , Moshiree Baharak , Morris Michele I. 
Published: September 2016

Abstract
Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.