bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Application of Traditional Chinese Medicine in Pneumonia Complicated with Heart Failure Based on Data Mining Algorithms
Authors: Yang Rongyuan , Deng Qingping , Zeng Xing , Cai Huayang , Liu Qing 
Published: September 2024

Objective:
This study aimed to investigate and analyze the existing literature regarding
the clinical utilization of Traditional Chinese Medicine (TCM) in cases of pneumonia complicated
by heart failure by employing data mining algorithms.

Methods:
The study gathered medical cases of treating pneumonia complicated with heart failure
from CNKI, Wanfang, VIP, and PubMed databases without imposing any temporal restrictions.
We extracted medication details and built a comprehensive database in Microsoft Excel 2019.
The analysis included frequency, cluster, and complex network analyses, along with association
rule visualization. These analytical procedures were executed using specialized software, such as
SPSS Statistics 26.0, SPSS Modeler 18.0, and Gephi.

Result:
This study included 47 articles meeting specific criteria, with 53 prescriptions and 110
different drugs. Pathological patterns observed included heart-yang deficiency, lung obstruction
by phlegm-heat, qi-yin deficiency, and internal closure with external prolapse. Medications fell
into categories like tonics, antitussives, heat-clearing, and wind-dispersing drugs, with cold,
warm, and neutral properties most common. Bitter, sweet, and pungent tastes were predominant.
Many drugs were found to target specific meridians like the lung, stomach, spleen, and heart.
Cluster analysis grouped 40 frequently used drugs into 6 categories, revealing complex relationships.
Network analysis identified core drugs for treating pneumonia complicated with heart
failure, emphasizing their importance in managing this complex medical condition.

Conclusion:
Key Chinese herbal medicines for pneumonia complicated with heart failure include
Ophiopogon japonicus, liquorice root, red ginseng, Ansu apricot seed, ginseng root, pepperweed
seed, and Chinese ephedra herb. They focus on promoting lung Qi, strengthening Qi
and blood, and improving blood circulation to address stasis. This data supports future clinical
research in managing pneumonia and heart failure.
Utilization of Plant based Nanoparticles Emerging in Nano-biomedical Science to Target Drug Deliveries for Breast Cancer Treatment: Existing
Work and Future Need
Authors: Munir Saba , Nawaz Yasir , Parveen Sara , Sadiqa Ayesha , Rehman Samiya , Riaz Hafiza Fizzah , Tanvir Fouzia , Saira  , Nawaz Aqeela , Naz Misbah , Nawaz Basit 
Published: September 2024

Abstract:
Cancer is a major global health concern and a hereditary disease brought on by alterations
in the genetic code that controls how cells behave. In the United States and other countries,
breast cancer is very common among females. Through the development of innovative biocompatible
Nanocomposites for therapy, which demonstrate a highly appropriate manner of nanoparticles,
Nanomedicine offers incredible potential to develop cancer treatment and diagnosis. More than
60% of anticancer medications on the market today are derived from natural sources. Historically,
plants have been used to treat a wide range of illnesses, including cancer. This work aimed to treat
breast cancer with plant-based nanoparticles. The information was gathered from research that has
already been published on Google Scholar, PubMed, and Web of Science. Different nanoparticles
have been shown to be effective drug delivery agents to treat breast cancer. These include gold, silver,
platinum, iron, zinc oxide, copper nanoparticles, and other metals, such as nickel, manganese,
silica, titanium, palladium, cerium, and platinum. It was discovered that all metal preparation nanoparticles
have an effective function in the treatment of infectious diseases and cancer. In conclusion,
the characteristics of biomolecules included in plant extracts may be connected to the greenproduced
NPs. Because of their high effectiveness, plant based NPs synthesis will be necessary in
the future to treat breast cancer.
Risk Factors of Age VS Other Comorbidities in Severe COVID-19: An Umbrella Review
Authors: SeyedAlinaghi SeyedAhmad , Mirzapour Pegah , Yarmohammadi Soudabeh , Afsahi Amir Masoud , Ahmadi Sepide , Roozbahani Mohammad Mahdi , Haghi Parnian , Karimi Elaheh , Mohammadi Sina , Tabari Amir , Molla Ayoob , Mehraeen Esmaeil 
Published: September 2024

Introduction:
This umbrella review offers a comprehensive analysis of the association
between age and other risk factors in the incidence and severity of COVID-19.

Method:
This umbrella review aims to compare age with other risk factors of COVID-19 infection.
Literature featuring systematic reviews and the English language in electronic databases of PubMed,
Embase, Scopus, and Web of Science was considered for this purpose. Appropriate articles were
selected following two separate steps, and after meeting the inclusion/exclusion criteria, they went
through data extraction. This umbrella review coheres with the PRISMA checklist and the
AMSTAR-2 tool specified for quality assessment.

Result:
A total of 55 articles met the inclusion criteria. For risk factors associated with COVID-19
severity, the most relevant were age and underlying comorbidities, each identified in 45 cases. Obesity
was noted in 12 cases, making it the least prevalent risk factor in the studies. Other factors included
sex, smoking, and conditions during hospitalization.For clinical outcomes, in addition to issues
such as discharge, ICU, death, etc., other issues such as renal and cardiovascular disorders were
observed.

Conclusion:
The collective evidence presented in this review underscores various risk factors associated
with severe COVID-19 outcomes, which can be used to update clinical management guidelines
and assist in determining patients’ prognoses.
Clinical and Laboratory Factors Associated with Mortality in ICU-Hospitalized COVID-19 Patients in a Western Center of Iran
Authors: Borzouei Shiva , Khazaei Salman , Nouri Reza , Tahmasebi Reza , Talebi-Ghane Elaheh 
Published: September 2024

Introduction:
The purpose of this study was to investigate the demographic, clinical, and
laboratory risk factors associated with mortality in Coronavirus disease 2019 (COVID-19) patients
who were admitted to the intensive care unit (ICU) in Iran.

Material & Methods:
This retrospective study analyzed data from 867 COVID-19 patients admitted
to the ICU of Shahid Beheshti Hospital in Hamadan (west of Iran) from September 2020 to March
2022. The association between demographic, clinical, and laboratory factors and mortality rates was
assessed using univariable and multiple logistic regression analysis.

Results:
During the study period, 512 (59.1%) patients were deceased from Covid-19. According to
the adjusted logistic regression, the odds of death in patients with an age higher than 60 years were
1.12 (95% CI: 1.01- 1.24; p=0.026). The OR estimate of death in patients with bradycardia and tachycardia
was 2.32 (95% CI: 1.72- 3.12; p < 0.001) and 2.40 (95% CI: 1.67- 3.42; p < 0.001), respectively.
Moreover, SPO2 lower than 88%, WBC over 11 ×1000μL, K over 5.2 mEq/L, and LDH
above 942 U/L were significantly associated with increased odds of death (p < 0.05).

Conclusion:
The study identified several demographic, clinical, and laboratory risk factors associated
with mortality in COVID-19 patients admitted to the ICU in Iran. These findings can help
healthcare providers identify patients at higher risk of poor outcomes and tailor interventions accordingly.
Management of Pneumomediastinum Patients in COVID-19: Rare Cases
Authors: Santosa Andrew , Djajalaksana Susanthy , Listyoko Aditya , Erawati Dini 
Published: September 2024

Background: Spontaneous pneumomediastinum in patients with confirmed cases of Covid-19 is a very rare clinical finding in the world, especially in Indonesia. This is considered an indication of concern for a more serious medical problem.
Aim: This case report discusses the management of COVID-19 patients with pneumomediastinum.
Case: A 30 year old man came to the hospital with the main complaint of shortness of breath and cough. The patient was diagnosed with a confirmed case of Covid-19 and received therapy using High Flow Nasal Cannula (HFNC) as a therapeutic modality. After 5 days in the hospital, the patient's shortness of breath felt increasingly severe, and he began to feel chest pain and swelling around the chest area which spread to both sides of his neck. A thorax x-ray examination showed pneumomediastinum and subcutaneous emphysema, then a chest CT scan was performed and the results showed pneumomediastinum which was thought to be caused by esophageal rupture. After we communicated with the Thoracic Surgery Department, conservative therapy was recommended.
Conclusion: Covid-19 infection can cause hypoxaemic respiratory failure and acute respiratory distress syndrome, both of which can be deadly. Supplementation of high-flow nasal cannula (HFNC) oxygen therapy can be very beneficial for patients, but can cause dangerous side effects such as pneumomediastinum. Pneumomediastinum (PM) is the presence of open air in the mediastinal cavity. In this case, we suspect that the pneumomediastinum was the result of Covid-19-related alveolar damage and esophageal rupture, and not due to the use of HFNC. Pneumomediastinum complications need to be detected early, so that management can reduce associated morbidity and mortality.

Keywords: Pneumomediastinum; COVID-19, HFNC
Health Professionals’ Views on the Use of Conversational Agents for Health Care: Qualitative Descriptive Study
Authors: MacNeill A Luke , MacNeill Lillian , Luke Alison , Doucet Shelley 
Published: September 2024

Background
In recent years, there has been an increase in the use of conversational agents for health promotion and service delivery. To date, health professionals’ views on the use of this technology have received limited attention in the literature.

Objective
The purpose of this study was to gain a better understanding of how health professionals view the use of conversational agents for health care.

Methods
Physicians, nurses, and regulated mental health professionals were recruited using various web-based methods. Participants were interviewed individually using the Zoom (Zoom Video Communications, Inc) videoconferencing platform. Interview questions focused on the potential benefits and risks of using conversational agents for health care, as well as the best way to integrate conversational agents into the health care system. Interviews were transcribed verbatim and uploaded to NVivo (version 12; QSR International, Inc) for thematic analysis.

Results
A total of 24 health professionals participated in the study (19 women, 5 men; mean age 42.75, SD 10.71 years). Participants said that the use of conversational agents for health care could have certain benefits, such as greater access to care for patients or clients and workload support for health professionals. They also discussed potential drawbacks, such as an added burden on health professionals (eg, program familiarization) and the limited capabilities of these programs. Participants said that conversational agents could be used for routine or basic tasks, such as screening and assessment, providing information and education, and supporting individuals between appointments. They also said that health professionals should have some oversight in terms of the development and implementation of these programs.

Conclusions
The results of this study provide insight into health professionals’ views on the use of conversational agents for health care, particularly in terms of the benefits and drawbacks of these programs and how they should be integrated into the health care system. These collective findings offer useful information and guidance to stakeholders who have an interest in the development and implementation of this technology.
Ayurveda Management of Allergic Rhinitis: Protocol for a Randomized Controlled Trial
Authors: Mata Shweta , Rajput Shivshankar , Tuli Isha Preet , Mundada Pallavi , Gupta Bharti , Srikanth Narayanam , Acharya Rabinarayanan 
Published: September 2024

Background
Allergic rhinitis (AR) is the inflammation of the membranes lining the nose due to allergen exposure and is characterized by sneezing, nasal congestion, itching of the nose, or postnasal discharge. The prevalence varies worldwide, perhaps due to the geographic and aeroallergen differences, with 10% to 30% of the world’s population experiencing AR. In this study, Anu Taila Nasya, Naradiya Laxmivilas Rasa, and Shirishadi Kwath will be compared to a fluticasone nasal spray.

Objective
The primary aim is to assess the efficacy of Ayurvedic management for AR (or vataja pratishyaya) by comparing it to a conventional control group. The secondary aims are to determine the mean change in the nasal endoscopy index and the mean change in the laboratory tests.

Methods
This ongoing study is an open-label randomized controlled interventional trial, with a sample size of 90 both in the trial and standard control group (including dropouts, 20%), and will be carried out for 24 months. Participants in the trial group will receive Ayurvedic treatment, that is, Anu Taila Nasya (6 drops in each nostril for 7 days for 3 consecutive weeks), Naradiya Laxmivilas Rasa (250 mg twice per day), and Shirishadi Kwath (40 ml twice per day for 45 days). The participants in the control group will receive a fluticasone propionate nasal spray (2 sprays once per day for 45 days). The primary outcome will include the mean change in the Control of Allergic Rhinitis and Asthma Test score, and the secondary outcomes will include the mean change in the nasal endoscopy index (assessment of nasal membrane color, pale or hyperemia; rhinorrhea, watery or yellow; and inferior turbinate swelling, hypertrophy) and the mean change in the laboratory tests.

Results
As of May 2024, 72 patients have been enrolled in both groups. Data analysis should be completed by February 2025. The study will be reported following standard guidelines for reporting randomized controlled trials. Clinical results will be disseminated through conferences and peer-reviewed publication in a relevant journal.

Conclusions
The Ayurvedic approach could be an evidence-based therapeutic tactic for the management of AR.

Trial Registration
Clinical Trials Registry India CTRI/2023/06/053395; https://tinyurl.com/564d2zz8

International Registered Report Identifier (IRRID)
DERR1-10.2196/56063
PENGARUH SUBSTITUSI TEPUNG JAGUNG KUNING (Zea mays L.) DAN PUREE WORTEL (Daucus carota L.) TERHADAP KARAKTERISTIK FISIKOKIMIA DAN ORGANOLEPTIK MIE BASAH
Authors: Olivia Dita Rizma , Damat Damat , Manshur Hanif Alamudin 
Published: September 2024

Wet noodles are food products made from wheat flour that are not dried. Every year, the production and consumption of noodles in Indonesia is increasing. So, there is a need for food diversification in the raw material by utilizing local food ingredients such as corn flour. The use of carrot puree aims to increase the carotenoid content which acts as a good antioxidant for the body. This research was conducted using a simple Randomized Block Design (RBD) method. There were 6 treatments and 4 replication, P0 (100% wheat flour), P1 (50% wheat flour: 50% corn flour), P2 (50% wheat flour : 45% corn flour: 5% carrot puree), P3 (50% wheat flour: 40% corn flour: 10% carrot puree), P4 (50% wheat flour: 35% corn flour: 15% carrot puree), P5 (50% wheat flour: 30% corn flour: 20% carrot puree). The best wet noodles were obtained from treatment P5 (50% wheat flour: 30% corn flour: 20% carrot puree) with moisture content of 70.05%, ash content of 0.26%, fat content of 6.94%, protein content of 4.65%, carbohydrates content of 18.08% and carotenoids content of 3.02 mg/100g, brightness 63.5, yield 172.44%, organoleptic color 4.13 (attractive), aroma 3.63 (quite like), taste 3.80 (good), and texture 2.65 (not chewy).
IDENTIDAD URBANA Y MEMORIA LA CALLE DEL COLORADO Y PARQUE DE SANTIAGO EN LA CIUDAD DE PASTO COLOMBIA
Authors: Salas Salazar Vicente Fernando , Figueroa Estrella Jorge Adrian 
Published: September 2024

El presente artículo basado en el trabajo de investigación titulado “Procesos Identitarios Urbanos en la Población del Sector del Parque Santiago y la Calle del Colorado de la Ciudad de Pasto Nariño”, tiene como objetivo principal identificar las características históricas y ahistóricas del sector de la calle del Colorado en la ciudad de Pasto, Colombia. Se aborda la pérdida de identidad de los residentes a medida que las costumbres y tradiciones se han adaptado a la dinámica de la ciudad, generando transformaciones en su identidad.
La investigación se enmarca en el paradigma sociocultural con énfasis en el enfoque cualitativo, lo que permite comprender las expresiones de los actores sociales, sus vivencias y experiencias en sus contextos sociales y culturales para la reconstrucción histórica. Se busca identificar los procesos identitarios urbanos del sector del parque Santiago y la calle del Colorado de la ciudad de Pasto, con el fin de corroborar la identidad cultural y los valores de dicho sector. Para ello, se plantea identificar los antecedentes de los hechos sucedidos en los sectores del Colorado y Santiago de la ciudad, determinar el conjunto de prácticas, expresiones culturales, sociales y políticas que han incidido en la construcción identitária de los habitantes de la calle del Colorado, y analizar los resultados obtenidos con relación a sus apreciaciones.
La observación de segundo orden y su relación con la historia cultural: una aproximación metodológica
Authors: Pabón Erazo John Jairo 
Published: September 2024

El presente artículo tiene por objetivo brindar un acercamiento a la observación de segundo orden como una herramienta metodológica dentro de la historia cultural. El texto surge a partir de una revisión bibliográfica y de la reflexión teórica y metodológica entre la historia cultural y la observación del segundo orden. Por consiguiente, se busca abrir perspectivas metodológicas que ayuden a comprender a la historia como un sistema de comunicación en general y a la historia cultural como una observación de la realidad en particular.
Efficacy of a new video observational training method (intensive visual simulation) for motor recovery in the upper limb in subacute stroke: a feasibility and proof-of-concept study
Authors: Ojardias Etienne , Adham Ahmed , Bessaguet Hugo , Phaner Virginie , Rimaud Diana , Giraux Pascal 
Published: September 2024

Objective: To demonstrate the feasibility and efficacy of a new video-observation training method (intensive visual simulation) to improve upper limb function.
Design: Small sample, randomized, evaluator-blind, monocentric study.
Patients: Seventeen early subacute ischaemic stroke patients with complete hemiplegia were randomly assigned to the therapeutic group (n = 8) or control group (CG, n = 9).
Methods: Thirty sessions of intensive visual simulation combined with corrected visual feedback (therapeutic group) or uncorrected visual feedback (control group) were performed over 6 weeks on top of a standard rehabilitation programme. Main outcome measure: 400-point hand assessment test (400p-HA). Secondary outcome measures: Box and Blocks (B&B), Purdue Pegboard test, Minnesota.
Results: The 400p-HA test improved significantly from T0 to 6 months for both groups, with a significant difference between groups at 3 months (MW-UT p = 0.046) and 4 months (MW-UT p = 0.046) in favour of the therapeutic group. One-phase exponential modelling of 400p-HA showed a greater plateau for the therapeutic group (F test p = 0.0021). There was also faster recovery of the ability to perform the B&B tests for the therapeutic group (log-rank test p = 0.03).
Conclusion: This study demonstrated the feasibility and potential efficacy of an intensive visual simulation training programme to improve upper limb function in subacute stroke patients. A larger study is needed to confirm these results.
Microaggressions in veterinary communication: what are they? How are they harmful? What can veterinary professionals and educators do?
Authors: Nishi Naomi W. , Collier Mary Jane , Morales Gabriela I. , Watley Erin 
Published: September 2024

Abstract
Trusting relationships between veterinary professionals and clients are important for the well-being of people and the ultimate health of their animals. Yet, microaggressions pose a threat to these relationships. Defined as slights or indignities wielded against people with marginalized identities, microaggressions inflict a unique form of harm that reaffirms negative stereotypes enmeshed in systems of racism, sexism, classism, and beyond. In this article, we explore how microaggressions work and how they are applicable in veterinary settings. We also offer initial suggestions for veterinary professionals and educators to better understand and counteract their damage in the profession.
A lex mercatoria e o capitalismo humanista: rumo a uma ordem econômica fraterna
Authors: Campos Tatiana , Benacchio Marcelo 
Published: September 2024

O presente estudo tratará do papel central que as empresas transnacionais desempenham na economia mundial, regulando o comércio internacional por meio da lex mercatoria. Essa atuação traz benefícios aos países em desenvolvimento, gerando emprego, renda e desenvolvimento tecnológico, no entanto, também causa impactos sobre os empregados, meio ambiente e as comunidades nas quais atuam, implicando também violações aos direitos humanos. Nesse contexto, o artigo que ora se apresenta defende a inclusão das dimensões da fraternidade na lex mercatoria, de modo a concretizar e promover os direitos humanos, bem como equilibrar o capitalismo, em busca de uma ordem econômica humana e fraterna. Por fim, menciona-se a Agenda 2030 como uma oportunidade para se consolidar o princípio da fraternidade na sociedade pós-moderna, por meio da materialização dos objetivos de desenvolvimento sustentável. Conclui-se que muito ainda falta para alcançar o desenvolvimento social pleno, de modo que todos os esforços devem ser cunhados, sobretudo pelas empresas transnacionais. Para o incremento do trabalho foi utilizado o método hipotético-dedutivo com análise documental e bibliográfica nacional e internacional.
Data-Driven Approach to the Development of an Aeroelastic Flutter Precursor
Authors: Meivar Boaz , Karpel Moti 
Published: September 2024

This paper presents a novel algorithm for aeroelastic flutter early detection. Two new features for flutter onset detection are presented. Flutter early warning is accomplished using only measured signals, with essentially no prior knowledge needed about the aircraft or the flutter mechanism involved. The algorithm consists of three stages: 1) extraction of regularity features, 2) calibration by addition of white noise to nominal measurements, and 3) thresholding. Four types of datasets were used: a) synthetic data, b) simulated data generated using aeroelastic response simulations to stochastic gusts, c) measured data from a wind tunnel experiment, and d) flight test data including actual flutter onsets. The algorithm was shown to be able to flag an impending flutter event before critical onset occurs. (The Python code for paper is available at https://github.com/bmeivar/flutter .)