bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mode jumping of split-ring resonator metamaterials controlled by high-permittivity BST and incident electric fields
Authors: Fu Xiaojian , Zeng Xinxi , Cui Tie Jun , Lan Chuwen , Guo Yunsheng , Zhang Hao Chi , Zhang Qian 
Published: August 2016

AbstractWe investigate the resonant modes of split-ring resonator (SRR) metamaterials that contain high-permittivity BST block numerically and experimentally. We observe interesting mode-jumping phenomena from the BST-included SRR absorber structure as the excitation wave is incident perpendicularly to the SRR plane. Specifically, when the electric field is parallel to the SRR gap, the BST block in the gap will induce a mode jumping from the LC resonance to plasmonic resonance (horizontal electric-dipole mode), because the displacement current excited by the Mie resonance in the dielectric block acts as a current channel in the gap. When the electric field is perpendicular to the gap side, the plasmonic resonance mode (vertical electric-dipole mode) in SRR changes to two joint modes contributed simultaneously by the back layer, SRR and BST block, as a result of connected back layer and SRR layer by the displacement current in the BST dielectric block. Based on the mode jumping effect as well as temperature and electric-field dependent dielectric constant, the BST-included SRR metamaterials may have great potentials for the applications in electromagnetic switches and widely tunable metamaterial devices.
MATSAP: An automated analysis of stretch-attend posture in rodent behavioral experiments
Authors: Holly Kevin S. , Orndorff Casey O. , Murray Teresa A. 
Published: August 2016

AbstractStretch-attend posture (SAP) occurs during risk assessment and is prevalent in common rodent behavioral tests. Measuring this behavior can enhance behavioral tests. For example, stretch-attend posture is a more sensitive measure of the effects of anxiolytics than traditional spatiotemporal indices. However, quantifying stretch-attend posture using human observers is time consuming, somewhat subjective, and prone to errors. We have developed MATLAB-based software, MATSAP, which is a quick, consistent, and open source program that provides objective automated analysis of stretch-attend posture in rodent behavioral experiments. Unlike human observers, MATSAP is not susceptible to fatigue or subjectivity. We assessed MATSAP performance with videos of male Swiss mice moving in an open field box and in an elevated plus maze. MATSAP reliably detected stretch-attend posture on par with human observers. This freely-available program can be broadly used by biologists and psychologists to accelerate neurological, pharmacological, and behavioral studies.
Ballistocardiogram: Mechanism and Potential for Unobtrusive Cardiovascular Health Monitoring
Authors: Kim Chang-Sei , Ober Stephanie L. , McMurtry M. Sean , Finegan Barry A. , Inan Omer T. , Mukkamala Ramakrishna , Hahn Jin-Oh 
Published: August 2016

AbstractFor more than a century, it has been known that the body recoils each time the heart ejects blood into the arteries. These subtle cardiogenic body movements have been measured with increasingly convenient ballistocardiography (BCG) instruments over the years. A typical BCG measurement shows several waves, most notably the “I”, “J” and “K” waves. However, the mechanism for the genesis of these waves has remained elusive. We formulated a simple mathematical model of the BCG waveform. We showed that the model could predict the BCG waves as well as physiologic timings and amplitudes of the major waves. The validated model reveals that the principal mechanism for the genesis of the BCG waves is blood pressure gradients in the ascending and descending aorta. This new mechanistic insight may be exploited to allow BCG to realize its potential for unobtrusive monitoring and diagnosis of cardiovascular health and disease.
Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation
Authors: Qin Shenlu , Wang Xumeng , Wu Huanwen , Xiao Peng , Cheng Hongqiang , Zhang Xue , Ke Yuehai 
Published: August 2016

AbstractMast cells play an essential role in initiating allergic diseases. The activation of mast cells are controlled by a complicated signal network of reversible phosphorylation and finding the key regulators involved in this network has been the focus of the pharmaceutical industry. In this work, we used a method named Time-dependent cell responding profile (TCRP) to track the process of mast cell degranulation under various perturbations caused by agents targeting phosphorylation. To test the feasibility of this high-throughput cell-based phenotypic screening method, a variety of biological techniques were used. We further screened 145 inhibitors and clustered them based on the similarities of their TCRPs. Stat3 phosphorylation has been widely reported as a key step in mast cell degranulation. Interestingly, our TCRP results showed that a Stat3 inhibitor JSI124 did not inhibit degranulation like other Stat3 inhibitors, such as Stattic, clearly inhibited degranulation. Regular endpoint assays demonstrated that the distinctive TCRP of JSI124 potentially correlated with the ability to induce apoptosis. Consequently, different agents possibly have disparate functions, which can be conveniently detected by TCRP. From this perspective, our TCRP screening method is reliable and sensitive when it comes to discovering and selecting novel compounds for new drug developments.
Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis
Authors: Harrisberger F , Smieskova R , Vogler C , Egli T , Schmidt A , Lenz C , Simon A E , Riecher-Rössler A , Papassotiropoulos A , Borgwardt S 
Published: August 2016

AbstractAlterations in hippocampal volume are a known marker for first-episode psychosis (FEP) as well as for the clinical high-risk state. The Polygenic Schizophrenia-related Risk Score (PSRS), derived from a large case–control study, indicates the polygenic predisposition for schizophrenia in our clinical sample. A total of 65 at-risk mental state (ARMS) and FEP patients underwent structural magnetic resonance imaging. We used automatic segmentation of hippocampal volumes using the FSL-FIRST software and an odds-ratio-weighted PSRS based on the publicly available top single-nucleotide polymorphisms from the Psychiatric Genomics Consortium genome-wide association study (GWAS). We observed a negative association between the PSRS and hippocampal volumes (β=−0.42, P=0.01, 95% confidence interval (CI)=(−0.72 to −0.12)) across FEP and ARMS patients. Moreover, a higher PSRS was significantly associated with a higher probability of an individual being assigned to the FEP group relative to the ARMS group (β=0.64, P=0.03, 95% CI=(0.08–1.29)). These findings provide evidence that a subset of schizophrenia risk variants is negatively associated with hippocampal volumes, and higher values of this PSRS are significantly associated with FEP compared with the ARMS. This implies that FEP patients have a higher genetic risk for schizophrenia than the total cohort of ARMS patients. The identification of associations between genetic risk variants and structural brain alterations will increase our understanding of the neurobiology underlying the transition to psychosis.
The Extended Pterional Approach and Microsurgery Resection for Craniopharyngiomas, Operative Nuances and Results: A Series of 29 Patients
Authors: Lynch Jose Carlos , Pereira Celestino , Manicacci Valérie , Gonçalves Mariangela , Welling Leonardo , Lenk Rudy 
Published: August 2016

Objective The aim of this paper is to observe if the extended pterional approach for the removal of craniopharyngiomas is safe and effective. The mortality, morbidity, and recurrence rates are presented and discussed.
Method This is a retrospective analysis of 29 craniopharyngioma patients who underwent surgery between January 1988 and December 2014 at the Department of Neurosurgery of the Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil. The charts, operative reports and imaging studies were reviewed.
Results We identified 17 males (58.6%) and 12 females (41.3%) ranging in age from 0.6 to 84 years (mean 57.4 years). Thirteen (44.8%) patients were infants or adolescents. Surgical mortality occurred in one patient (3.4%). Gross total tumor removal was achieved in 15 (51.7%) patients. The median follow-up time was 7.1 years.
Conclusion The extended pterional approach provides adequate access to craniopharyngiomas, and the majority of lesions could be totally removed, with a low mortality rate, but the best treatment for craniopharyngiomas remains controversial.
Early emerging system for reasoning about the social nature of food
Authors: Liberman Zoe , Woodward Amanda L. , Sullivan Kathleen R. , Kinzler Katherine D. 
Published: August 2016

SignificanceFood choice can serve as a social shibboleth, whereby information about what an individual eats affords insight into her cultural background and social relationships. We provide evidence for an early-emerging system linking food preferences to social identity. Infants expect people to share food preferences, unless those people belong to different groups, suggesting human reasoning about food preferences is fundamentally social. However, infants generalize disgust toward a food even across people who belong to different groups, suggesting that infants are particularly vigilant to social information that might signal danger. This research opens new lines of investigation regarding infant social cognition and food selection across the lifespan, and has implications for social policy surrounding nutrition, heath, and obesity.
Climate influence on
Vibrio
and associated human diseases during the past half-century in the coastal North Atlantic
Authors: Vezzulli Luigi , Grande Chiara , Reid Philip C. , Hélaouët Pierre , Edwards Martin , Höfle Manfred G. , Brettar Ingrid , Colwell Rita R. , Pruzzo Carla 
Published: August 2016

Significance
Long-term ecological and paleontological data analyses indicate climate change is having an impact on marine eukaryotic communities. However, little is known about effects of global warming on marine prokaryotes, which are, by far, the largest living biomass in world oceans. Here, we report, for the first time to our knowledge, that a warming trend in sea surface temperature is strongly associated with spread of vibrios, an important group of marine prokaryotes, and emergence of human diseases caused by these pathogens. Our results are based on formalin-preserved plankton samples collected in the past half-century from the temperate North Atlantic.
Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates
Authors: Duque Alvaro , Krsnik Zeljka , Kostović Ivica , Rakic Pasko 
Published: August 2016

Significance
The subplate zone, a transient cellular compartment of the embryonic cerebrum, has expanded in size and complexity during primate evolution, culminating in humans. Here, the application of multiple methods, including labeling time and place of neuronal origin and subsequent changes in their positions in macaque monkey embryos, and the use of histo- and immunochemistry in human fetal cerebral tissue of comparable prenatal ages reveals extraordinary cellular dynamics and unexpected secondary displacement of neurons. These findings may have significance for understanding cortical development and evolution and may provide insight into the pathogenesis of cortical disorders, as well as hypoxic-ischemic lesions in preterm infants.
A critical approach proposal for training translation memory systems in translator education programs
Authors: de Andrade Stupiello Erika Nogueira , Esqueda Marileide Dias 
Published: August 2016

Abstract
The fast pace of todays translation market and the definite integration of translation memory systems TMS in the translators workstation have created new demands in terms of technological skills expected from novice translators. Aiming to prepare future translators to meet market demands, many translation undergraduate programs in Brazil have included the training on translation memory systems in their curricula. Applying the action-research methodology, this paper reports on the training methodology used for TMS in translation classrooms at two Brazilian public universities. The collected data in both contexts suggest that TMS may affect both the composing of the final translation and the decision-making of trainee translators and the quality of their production if they do not reflectively challenge their choices and the suggested output.
PRODIGY: a web server for predicting the binding affinity of protein–protein complexes
Authors: Xue Li C. , Rodrigues João Pglm , Kastritis Panagiotis L. , Bonvin Alexandre Mjj , Vangone Anna 
Published: August 2016

Summary: Gaining insights into the structural determinants of protein–protein interactions holds the key for a deeper understanding of biological functions, diseases and development of therapeutics. An important aspect of this is the ability to accurately predict the binding strength for a given protein–protein complex. Here we present PROtein binDIng enerGY prediction (PRODIGY), a web server to predict the binding affinity of protein–protein complexes from their 3D structure. The PRODIGY server implements our simple but highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface.
Availability and Implementation: PRODIGY is freely available at: http://milou.science.uu.nl/services/PRODIGY.
Contact: a.m.j.j.bonvin@uu.nl, a.vangone@uu.nl
Bayesian network feature finder (BANFF): an R package for gene network feature selection
Authors: Lan Zhou , Zhao Yize , Kang Jian , Yu Tianwei 
Published: August 2016

Motivation: Network marker selection on genome-scale networks plays an important role in the understanding of biological mechanisms and disease pathologies. Recently, a Bayesian nonparametric mixture model has been developed and successfully applied for selecting genes and gene sub-networks. Hence, extending this method to a unified approach for network-based feature selection on general large-scale networks and creating an easy-to-use software package is on demand.Results: We extended the method and developed an R package, the Bayesian network feature finder (BANFF), providing a package of posterior inference, model comparison and graphical illustration of model fitting. The model was extended to a more general form, and a parallel computing algorithm for the Markov chain Monte Carlo -based posterior inference and an expectation maximization-based algorithm for posterior approximation were added. Based on simulation studies, we demonstrate the use of BANFF on analyzing gene expression on a protein–protein interaction network.Availability: https://cran.r-project.org/web/packages/BANFF/index.htmlContact: jiankang@umich.edu, tianwei.yu@emory.eduSupplementary information: Supplementary data are available at Bioinformatics online.
Fecal incontinence
Authors: Fejka Michael David 
Published: August 2016

ABSTRACT
Fecal incontinence affects patients of all sexes, races, and ethnicities; however, those affected often are afraid or too embarrassed to ask for help. Attention to risk factors and directed physical examinations can help healthcare providers diagnose and formulate treatment plans. Numerous diagnostic tests are available. Diligent follow-up is needed to direct patients to second-line therapies such as sacral nerve stimulation or surgical procedures.
Epidemiology of severe anaphylaxis: can we use population-based data to understand anaphylaxis?
Authors: Turner Paul J. , Campbell Dianne E. 
Published: August 2016

Purpose of review
The observed increase in incidence of allergic disease in many regions over the past 3 decades has intensified interest in understanding the epidemiology of severe allergic reactions. We discuss the issues in collecting and interpreting these data and highlight current deficiencies in the current methods of data gathering.

Recent findings
Anaphylaxis, as measured by hospital admission rates, is not uncommon and has increased in the United Kingdom, the United States, Canada, and Australia over the last 10–20 years. All large datasets are hampered by a large proportion of uncoded, ‘unspecified’ causes of anaphylaxis. Fatal anaphylaxis remains a rare event, but appears to be increasing for medication in Australia, Canada, and the United States. The rate of fatal food anaphylaxis is stable in the United Kingdom and the United States, but has increased in Australia. The age distribution for fatal food anaphylaxis is different to other causes, with data suggesting an age-related predisposition to fatal outcomes in teenagers and adults to the fourth decade of life.

Summary
The increasing rates of food and medication allergy (the latter exacerbated by an ageing population) has significant implications for future fatality trends. An improved ability to accurately gather and analyse population-level anaphylaxis data in a harmonized fashion is required, so as to ultimately minimize risk and improve management.
Choosing Wisely for Medical Education: Six Things Medical Students and Trainees Should Question
Authors: Lakhani Anand , Lass Elliot , Silverstein William K. , Born Karen B. , Levinson Wendy , Wong Brian M. 
Published: August 2016

Problem
Physician behaviors that promote overuse of health care resources develop early in training, and the medical education environment helps foster such behaviors. The authors describe the development of a Choosing Wisely list for medical students aimed at helping to curb overuse.

Approach
The list was developed in 2015 by Choosing Wisely Canada (CWC) in partnership with the Canadian Federation of Medical Students and the Fédération médicale étudiante du Québec, which together represent all medical students in Canada. CWC convened a student-led taskforce to develop recommendations targeting medical student behaviors with respect to resource stewardship practices. Students at all 17 Canadian medical schools were consulted via an online questionnaire to solicit feedback on a list of 10 candidate recommendations. The taskforce used this student feedback in finalizing the list.

Outcomes
The final list of “Six Things That Medical Students and Trainees Should Question” highlights both behaviors students should avoid (e.g., “Don’t suggest ordering the most invasive test before considering other less invasive options”) and behaviors related to aspects of medical training that may promote overuse, such as the hierarchical nature of clinical supervision (e.g., “Don’t hesitate to ask for clarification on tests, treatments, or procedures that you believe may be ordered inappropriately”). Based on student requests for illustrative examples, clinical vignettes were developed.

Next Steps
This list highlights medical student behaviors and aspects of the academic environment that drive overuse. It is also relevant to faculty, whose behaviors and supervision practices influence trainees.
Optimizing Cognitive Function in Persons With Chronic Pain
Authors: Baker Katharine S. , Georgiou-Karistianis Nellie , Gibson Stephen J. , Giummarra Melita J. 
Published: August 2016

Objectives:
Cognitive functioning is commonly disrupted in people living with chronic pain, yet it is an aspect of pain that is often not routinely assessed in pain management settings, and there is a paucity of research on treatments or strategies to alleviate the problem. The purpose of this review is to outline recent research on cognitive deficits seen in chronic pain, to give an overview of the mechanisms involved, advocate cognitive functioning as an important target for treatment in pain populations, and discuss ways in which it may be assessed and potentially remediated.

Methods:
A narrative review.

Results:
There are several options for remediation, including compensatory, restorative, and neuromodulatory approaches to directly modify cognitive functioning, as well as physical, psychological, and medication optimization methods to target secondary factors (mood, sleep, and medications) that may interfere with cognition.

Discussion:
We highlight the potential to enhance cognitive functions and identify the major gaps in the research literature.
Effects of Different Crystalloid Solutions on Hemodynamics, Peripheral Perfusion, and the Microcirculation in Experimental Abdominal Sepsis
Authors: Orbegozo Diego , Su Fuhong , Santacruz Carlos , He Xinrong , Hosokawa Koji , Creteur Jacques , De Backer Daniel , Vincent Jean-Louis 
Published: August 2016

AbstractBackgroundCrystalloid solutions are used to restore intravascular volume in septic patients, but each solution has limitations. The authors compared the effects of three crystalloid solutions on hemodynamics, organ function, microcirculation, and survival in a sepsis model.MethodsPeritonitis was induced by injection of autologous feces in 21 anesthetized, mechanically ventilated adult sheep. After baseline measurements, animals were randomized to lactated Ringer’s (LR), normal saline (NS), or PlasmaLyte as resuscitation fluid. The sublingual microcirculation was assessed using sidestream dark field videomicroscopy and muscle tissue oxygen saturation with near-infrared spectroscopy.ResultsNS administration was associated with hyperchloremic acidosis. NS-treated animals had lower cardiac index and left ventricular stroke work index than LR-treated animals from 8 h and lower mean arterial pressure than LR-treated animals from 12 h. NS-treated animals had a lower proportion of perfused vessels than LR-treated animals after 12 h (median, 82 [71 to 83] vs. 85 [82 to 89], P = 0.04) and greater heterogeneity of proportion of perfused vessels than PlasmaLyte or LR groups at 18 h. Muscle tissue oxygen saturation was lower at 16 h in the NS group than in the other groups. The survival time of NS-treated animals was shorter than that of the LR group (17 [14 to 20] vs. 26 [23 to 29] h, P &lt; 0.01) but similar to that of the PlasmaLyte group (20 [12 to 28] h, P = 0.74).ConclusionsIn this abdominal sepsis model, resuscitation with NS was associated with hyperchloremic acidosis, greater hemodynamic instability, a more altered microcirculation, and more severe organ dysfunction than with balanced fluids. Survival time was shorter than in the LR group.