bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross border semantic interoperability for learning health systems: The EHR4CR semantic resources and services
Authors: Daniel Christel , Ouagne David , Sadou Eric , Paris Nicolas , Hussain Sajjad , Jaulent Marie‐Christine , Kalra Dipak 
Published: October 2016

AbstractWith the development of platforms enabling the integration and use of phenome, genome, and exposome data in the context of international research, data management challenges are increasing, and scalable solutions for cross border and cross domain semantic interoperability need to be developed. Reusing routinely collected clinical data, especially, requires computable portable phenotype algorithms running across different electronic health record (EHR) products and healthcare systems. We propose a framework for describing and comparing mediation platforms enabling cross border phenotype identification within federated EHRs. This framework was used to describe the experience gained during the EHR4CR project and the evaluation of the platform developed for accessing semantically equivalent data elements across 11 European participating EHR systems from 5 countries. Developers of semantic interoperability platforms are beginning to address a core set of requirements in order to reach the goal of developing cross border semantic integration of data.
A Modified Polysaccharide‐Based Hydrogel for Enhanced Osteogenic Maturation and Mineralization Independent of Differentiation Factors
Authors: Sanyasi Sridhar , Kumar Satish , Ghosh Arijit , Majhi Rakesh Kumar , Kaur Navneet , Choudhury Priyanka , Singh Udai P. , Goswami Chandan , Goswami Luna 
Published: October 2016

Bone related problems are increasing as a consequence of increased life expectancy, disorders in life style, and other medical conditions enforcing the need for functional bones prepared in vitro at affordable cost. Lack of suitable surface which promotes growth of both osteogenic and nonosteogenic cells is a major limitation. Here a novel biomaterial is reported that is synthesized from natural polysaccharide, namely, tamarind kernel polysaccharide (TKP), which is grafted with hydrophilic acrylic acid (AA) by radical polymerization. Modification in surface functionality removes unwanted proteins and alters hydrophilic/hydrophobic balance. TKP‐AA is suitable for the growth of different nonosteogenic and osteogenic cells. This material is suitable for osteoblasts and promotes in vitro mineralization and differentiation without the addition of exogenous growth factors. TKP‐AA can be used for the growth of mesenchymal stem cell‐derived osteoblasts. It is suggested that TKP‐AA can potentially be used as a scaffold for diverse cell types and particularly for bone tissue engineering at low cost.
image
Influence of Sonication on Morphological Properties of Poly(Vinyl Acetate) Particles Produced Through Suspension Polymerization
Authors: Azevedo Gustavo D. , Melo Príamo A. , Pinto José Carlos 
Published: October 2016

SummaryThe use of polymers for various medical purposes has increased significantly over the past few years, including vascular embolization procedures. The main challenge in this particular case is the development of embolic agents with suitable properties in order to render the application safer and reproducible. In this context, particle density plays a fundamental role in vascular embolization performance, since off‐spec values can lead to undesired sedimentation of particles during the medical procedure. The influence of sonication power on the morphology of polymer particles produced through suspension polymerizations was investigated in the present work, as well as the effects of adding polymer material into the initial monomer dispersion on the final morphological properties of the product. It is shown in particular that the investigated morphological properties (density, shape, porosity) depend on the operation conditions on manners that have not been discussed in the literature.
Effect of the Chemical Structure of Compatibilizers on the Thermal, Mechanical and Morphological Properties of Immiscible PLA/PCL Blends
Authors: Finotti Pablo F. M. , Costa Lidiane C. , Chinelatto Marcelo A. 
Published: October 2016

SummaryThis manuscript addresses the effect of the chemical structure of two block copolymers of low molecular weight employed as compatibilizers on the immiscible blends of poly(lactic acid) (PLA) and poly(ϵ‐caprolactone) (PCL). Binary and ternary blends were prepared by melt mixing in a twin screw extruder and the effect of the block copolymers on the morphological, mechanical and thermal behavior was investigated by scanning electron microscopy (SEM), tensile testing and differential scanning calorimetry (DSC). The addition of 5 wt% of block copolymers derived from ϵ‐caprolactone and 1,4 butanediol (C1) or ϵ‐caprolactone and an aliphatic polycarbonate (C2) maintained the size of the dispersed PCL domains practically constant, regardless of the PCL concentration. The compatibilized PLA/PCL blends containing 5 wt% of PCL exhibited a significant enhancement in elongation at break, in comparison to those of the neat PLA or uncompatibilized PLA/PCL blends. The DSC results show the melting temperatures of the PLA were not influenced by the chemical structure of the compatibilizers or PCL concentration. However, such variables changed the melting enthalpy of the PLA and PCL and melting temperature of the PCL.
Age‐at‐onset subsets of bipolar I disorders: A critical insight into admixture analyses
Authors: Montlahuc Claire , Curis Emmanuel , Jonas Sarah Flora , Bellivier Frank , Chevret Sylvie 
Published: October 2016

AbstractGaussian mixture analysis is frequently used to model the age‐at‐onset (AAO) in bipolar I disorder and identify homogeneous subsets of patients. This study aimed to examine whether, using admixture analysis of AAO, cross‐sectional designs (which cause right truncation), unreliable diagnosis for individuals younger than 10 years old (which causes left truncation) and the selection criterion used for admixture analysis impact the number of identified subsets. A simulation study was performed. Different criteria – the likelihood ratio test (LRT), the Akaike information criterion (AIC), and the Bayesian information criterion (BIC) – were compared using no, left and/or right truncation simulated data. The error rate of each criterion (percentage of erroneous number of detected subsets) was estimated. An application to two real databases, including 2,876 and 1,393 patients, is provided. Without data truncation and regardless of the distribution of AAO, the LRT and the AIC had much higher error rates (12% and 33%, respectively) than the BIC (1%). For a homogeneous population, the error rate increased with the introduction of left truncation. This study shows that the number of subsets identified using admixture analysis may depend on the sample size, the selection criterion, and the study design.
The obesity associated FTO gene variant and the risk of adverse pregnancy outcomes: Evidence from the SCOPE study
Authors: Andraweera Prabha H. , Dekker Gustaaf A. , Leemaqz Shalem , McCowan Lesley , Roberts Claire T. ,   on behalf of the SCOPE consortium
Published: October 2016

ObjectiveTo investigate whether the FTO rs9939609 single nucleotide polymorphism (SNP), which is a risk factor for obesity and vascular diseases, is also associated with pregnancy complications including pre‐eclampsia, gestational hypertension, small for gestational age pregnancy (SGA), and spontaneous preterm birth (sPTB).MethodsA case‐control study of 1,741 nulliparous Caucasian women, their partners, and infants was conducted. DNA was extracted from peripheral blood or saliva from parents and cord blood from infants and genotyped using the Sequenom MassARRAY system.ResultsThe prevalence of maternal and infant AA genotype of FTO rs9939609 was increased in the SGA group compared with the uncomplicated pregnancy group (19.2% vs. 13.4%, OR = 1.7, 95% CI = 1.1‐2.6, P = 0.02 and 24.6% vs. 12.5%, OR = 2.7, 95% CI = 1.6‐4.6, P = 0.0002). The prevalence of maternal and infant AA genotype of FTO rs9939609 was also increased in the sPTB group compared with the uncomplicated pregnancy group (20.8% vs. 13.4%, OR = 2.1, 95% CI = 1.2‐3.8, P = 0.009 and 20.0% vs. 12.5%, OR = 2.4, 95% CI = 1.0‐5.3, P = 0.03).ConclusionsThe maternal and infant AA genotype of the obesity associated FTO rs9939609 SNP associates with increased risk for SGA and sPTB. This SNP may be important in predicting the risk of these pregnancy complications and subsequent vascular diseases.
Individual differences in positive and negative emotion regulation: Which strategies explain variability in loneliness?
Authors: Kearns Sinead M. , Creaven Ann‐Marie 
Published: October 2016

AbstractLoneliness is the distressing feeling accompanying the perception that one's social needs are not being met by one's social relationships. Conceptual models point to a role for cognitive factors in this experience. Because research on determinants of loneliness is sparse, this study investigates associations between individual differences in emotion regulation (ER) and loneliness. Participants (N = 116) completed measures of loneliness, and a vignette‐based measure of adaptive and maladaptive ER in response to positive and negative scenarios. Regression analyses indicated that the regulation of positive and negative emotions explained comparable variance in loneliness, and associations were only partially reduced by the inclusion of social support. The specific strategies positive reappraisal, being present and negative mental time travel explained the most variance in loneliness. The findings are consistent with both the cognitive and the social needs models of loneliness and suggest that variability in ER strategies should be considered relevant to loneliness. Copyright © 2016 John Wiley & Sons, Ltd.
Perylene and naphthalene diimide copolymers for all‐polymer solar cells: Effect of perylene/naphthalene ratio
Authors: Dai Shuixing , Huang Shuai , Yu Haifeng , Ling Qidan , Zhan Xiaowei 
Published: October 2016

ABSTRACTWe report the synthesis of a series of copolymers, having 2,2′‐bithiophene as electron‐donating moiety, and perylene diimide (PDI) and/or naphthalene diimide (NDI) as electron‐accepting moiety, and employed as non‐fullerene acceptors in polymer solar cells (PSCs). All the copolymers show wide absorption varying from 300 to 850 nm in the visible and NIR spectrum. When changing the PDI/NDI ratio in the polymer backbone, The LUMO energy levels vary in the range of −3.90 to −3.80 eV and the HOMO energy levels vary in the range of −6.10 to −5.85 eV. Among PSCs based on PTB7‐Th donor and these polymer acceptors, the devices based on PTB7‐Th/NDI100 yield the best power conversion efficiency (PCE) of 4.67%, while the PTB7‐Th/PDI100‐based devices yield a PCE of 1.03%. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 682–689
A simple and reliable anion‐exchange resin method for sulfate extraction and purification suitable for multiple O‐ and S‐isotope measurements
Authors: Le Gendre Erwann , Martin Erwan , Villemant Benoit , Cartigny Pierre , Assayag Nelly 
Published: October 2016

RationaleThe O‐ and S‐isotope compositions of sulfates can be used as key tracers of the fate and sink of sulfate in both terrestrial and extra‐terrestrial environments. However, their application remains limited in those geological systems where sulfate occurs in low concentrations. Here we present a simple and reliable method to extract, purify and concentrate sulfate from natural samples. The method allows us to take into account the separation of nitrate, which is known to be an issue in O‐isotope analysis.MethodsThe separation and concentration of sulfate from other anions in any aqueous solution are performed within a few hours via anion‐exchange resin. The possible O‐ (δ18O and Δ17O) and S‐ (δ34S, Δ33S and Δ36S) isotope exchanges, fractionations and/or contaminations are for the first time monitored during the whole procedure using initial O‐ and S‐mass‐dependent and mass‐independent sulfate solutions.ResultsAfter elution in HCl, pure sulfate is fully retrieved and precipitated into BaSO4, which is suitable for O‐ and S‐isotopic measurements using established techniques. The analysis of retrieved barite presents no variation within 2σ uncertainties: ±0.5‰ and ±0.1‰ in O‐ (δ18O, Δ17O) and ±0.2‰, ±0.02‰ and ±0.09‰ in S‐ (δ34S, Δ33S and Δ36S) isotope ratios, respectively.ConclusionsThis study shows that the resin method for sulfate extraction and purification, in addition to being cheap, simple and quick, is applicable for the measurements of all O‐ and S‐isotopic ratios in sulfates (including the Δ17O, Δ33S and Δ36S values). Therefore, this method can be easily used for a high range of natural samples in which sulfate occurs in low concentration including aerosols, ice cores, sediments, volcanic deposits, (paleo)soils and rainwater, and thus it can be a key to our understanding of the sulfur cycle on Earth. Copyright © 2016 John Wiley & Sons, Ltd.
Robotic, laparoscopic, and open colectomy: a case‐matched comparison from the ACS‐NSQIP
Authors: Benlice Cigdem , Aytac Erman , Costedio Meagan , Kessler Hermann , Abbas Maher A. , Remzi Feza H. , Gorgun Emre 
Published: October 2016

AbstractBackgroundThis study aimed to compare perioperative outcomes of patients undergoing robotic, laparoscopic, and open colectomy using a procedure‐targeted database.MethodsRetrospective review of patients undergoing elective colectomy in 2013 was conducted using the procedure‐targeted database of the American College of Surgeons National Surgical Quality Improvement Program (ACS‐NSQIP). Robotic, laparoscopic, and open groups were matched (1:1:1) based on age, gender, body mass index, surgical procedure, diagnosis and ASA classification. Demographics, comorbidities, and short‐term (30 day) outcomes were compared.ResultsOut of 12 790 patients, 387 fulfilled criteria per group after matching. Univariate comparison showed operating time was longer (P < 0.001) and hospital stay was shorter (P < 0.001) in the robotic group. Morbidity (P < 0.001), superficial SSI (P < 0.001), bleeding requiring transfusion (P < 0.001), ventilator dependency (P = 0.003), and ileus (P < 0.001) rates were lower in the robotic group. After adjusting for confounders, outcomes were comparable between the groups except hospital stay which was shorter in the robotic group (P < 0.001).ConclusionsACS‐NSQIP data demonstrated several short‐term advantages of robotic surgery compared with laparoscopic and open surgery.
Auditing the Physical Activity and Parkinson Disease Literature Using the Behavioral Epidemiologic Framework
Authors: Swank Chad , Shearin Staci , Cleveland Samantha , Driver Simon 
Published: October 2016

AbstractMotor and nonmotor symptoms associated with Parkinson disease place individuals at greater risk of sedentary behaviors and comorbidities. Physical activity is one modifiable means of improving health and reducing the risk of morbidity. We applied a behavioral framework to classify existing research on physical activity and Parkinson disease to describe the current evolution and inform knowledge gaps in this area. Research placed in phase 1 establishes links between physical activity and health‐related outcomes; phase 2 develops approaches to quantify physical activity behavior; phase 3 identifies factors associated with implementation of physical activity behaviors; phase 4 assesses the effectiveness of interventions to promote activity; and phase 5 disseminates evidence‐based recommendations. Peer‐reviewed literature was identified by searching PubMed, Google Scholar, and EBSCO‐host. We initially identified 287 potential articles. After further review, we excluded 109 articles, leaving 178 included articles. Of these, 75.84% were categorized into phase 1 (n = 135), 10.11% in phase 2 (n = 18), 9.55% into phase 3 (n = 17), 3.37% into phase 4 (n = 6), and 1.12% into phase 5 (n = 2). By applying the behavioral framework to the physical activity literature for people with Parkinson disease, we suggest this area of research is nascent with more than 75% of the literature in phase 1.Level of EvidenceIII
Design rules for more resilient banking systems
Authors: Selmier W Travis 
Published: October 2016

Abstract
Effective financial policy design should incorporate design principles encouraging financial activity and innovation while discouraging excessive risk-taking, into an inclusive, environmental approach to financial system governance. Examining banking systems in Australia, Brazil, Canada and China — whose financial systems proved more resilient than those in the US and much of Europe in the recent global financial crisis — helps us to uncover design rules which strengthen the financial environment and enhance financial resilience. In effect, policy-makers in these four countries struck an oligopolistic bargain with their domestic top banks. This bargain established national banking boundaries behind which indigenous national banks developed, protected banks from foreign competition and threat of acquisition, and enabled banks to pursue lower risk banking business. In return, banks acted as stewards of their financial environments. This bargain recognized the interlinked, network nature of financial risk and integrated governmental regulation with private actor governance structures.
Monitoring and evaluating capacity building activities in low and middle income countries: challenges and opportunities
Authors: Schneider M. , van de Water T. , Araya R. , Bonini B. B. , Pilowsky D. J. , Pratt C. , Price L. , Rojas G. , Seedat S. , Sharma M. , Susser E. 
Published: October 2016

BackgroundLower and middle income countries (LMICs) are home to >80% of the global population, but mental health researchers and LMIC investigator led publications are concentrated in 10% of LMICs. Increasing research and research outputs, such as in the form of peer reviewed publications, require increased capacity building (CB) opportunities in LMICs. The National Institute of Mental Health (NIMH) initiative, Collaborative Hubs for International Research on Mental Health reaches across five regional ‘hubs’ established in LMICs, to provide training and support for emerging researchers through hub-specific CB activities. This paper describes the range of CB activities, the process of monitoring, and the early outcomes of CB activities conducted by the five research hubs.MethodsThe indicators used to describe the nature, the monitoring, and the early outcomes of CB activities were developed collectively by the members of an inter-hub CB workgroup representing all five hubs. These indicators included but were not limited to courses, publications, and grants.ResultsResults for all indicators demonstrate a wide range of feasible CB activities. The five hubs were successful in providing at least one and the majority several courses; 13 CB recipient-led articles were accepted for publication; and nine grant applications were successful.ConclusionsThe hubs were successful in providing CB recipients with a wide range of CB activities. The challenge remains to ensure ongoing CB of mental health researchers in LMICs, and in particular, to sustain the CB efforts of the five hubs after the termination of NIMH funding.
Grand Challenges in Protoplanetary Disc Modelling
Authors: Haworth Thomas J. , Ilee John D. , Forgan Duncan H. , Facchini Stefano , Price Daniel J. ,   Community authors, Boneberg Dominika M. , Booth Richard A. , Clarke Cathie J. , Gonzalez Jean-François , Hutchison Mark A. , Kamp Inga , Laibe Guillaume , Lyra Wladimir , Meru Farzana , Mohanty Subhanjoy , Panić Olja , Rice Ken , Suzuki Takeru , Teague Richard , Walsh Catherine , Woitke Peter 
Published: October 2016

AbstractThe Protoplanetary Discussions conference—held in Edinburgh, UK, from 2016 March 7th–11th—included several open sessions led by participants. This paper reports on the discussions collectively concerned with the multi-physics modelling of protoplanetary discs, including the self-consistent calculation of gas and dust dynamics, radiative transfer, and chemistry. After a short introduction to each of these disciplines in isolation, we identify a series of burning questions and grand challenges associated with their continuing development and integration. We then discuss potential pathways towards solving these challenges, grouped by strategical, technical, and collaborative developments. This paper is not intended to be a review, but rather to motivate and direct future research and collaboration across typically distinct fields based on community-driven input, to encourage further progress in our understanding of circumstellar and protoplanetary discs.
“Liberal Arts are an Islamic Idea”: Subjectivity Formation at Islamic Universities in The West
Authors: Sinclair Kirstine 
Published: October 2016

AbstractThe aim of this project is to discuss how Islamic universities in the West facilitate and condition the formation of modern Muslim subjectivities. The central question of the study is: How is the formation of modern forms of subjectivities tied together with the reinterpretation of Islamic traditions? The paper provides analysis of the curricula, and institution background, values and aims of two universities—Zaytuna College in Berkeley, California, the first Muslim liberal arts college in the U.S.; and Cambridge Muslim College, the first to offer a Diploma in Muslim community leadership in Britain. Alongside the textually founded analysis, interviews conducted with leadership, faculty and students, and participatory observation inform the discussion. Analysis demonstrates that both institutions see themselves as mediators between Islamic traditions and modern Muslims in the West, and as having a responsibility to engage in the development of both Muslim minorities and the wider societies within which they operate.
The influence of energy standardisation on the alternate Mediterranean diet score and its association with mortality in the Multiethnic Cohort
Authors: Shvetsov Yurii B. , Harmon Brook E. , Ettienne Reynolette , Wilkens Lynne R. , Le Marchand Loic , Kolonel Laurence N. , Boushey Carol J. 
Published: October 2016

AbstractThe alternate Mediterranean diet (aMED) score is an adaptation of the original Mediterranean diet score. Raw (aMED) and energy-standardised (aMED-e) versions have been used. How the diet scores and their association with health outcomes differ between the two versions is unclear. We examined differences in participants’ total and component scores and compared the association of aMED and aMED-e with all-cause, CVD and cancer mortality. As part of the Multiethnic Cohort, 193 527 men and women aged 45–75 years from Hawaii and Los Angeles completed a baseline FFQ and were followed up for 13–18 years. The association of aMED and aMED-e with mortality was examined using Cox’s regression, with adjustment for total energy intake. The correlation between aMED and aMED-e total scores was lower among people with higher BMI. Participants who were older, leaner, more educated and consumed less energy scored higher on aMED-e components compared with aMED, except for the red and processed meat and alcohol components. Men reporting more physical activity scored lower on most aMED-e components compared with aMED, whereas the opposite was observed for the meat component. Higher scores of both aMED and aMED-e were associated with lower risk of all-cause, CVD and cancer mortality. Although individuals may score differently with aMED and aMED-e, both scores show similar reductions in mortality risk for persons scoring high on the index scale. Either version can be used in studies of diet and mortality. Comparisons can be performed across studies using different versions of the score.