bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Template Synthesis of Hybrid Porous Co3O4–CeO2 Hollow Polyhedrons for High‐Performance Supercapacitors
Authors: Wei Chengzhen , Liu Kangfei , Tao Jing , Kang Xiaoting , Hou Haiyan , Cheng Cheng , Zhang Daojun 
Published: December 2017

AbstractIn this work, hybrid porous Co3O4–CeO2 hollow polyhedrons have been successfully obtained via a simple cation‐exchange route followed by heat treatment. In the synthesis process, ZIF‐67 polyhedron frameworks are firstly prepared, which not only serve as a host for the exchanged Ce3+ ions but also act as the template for the synthesis of hybrid porous Co3O4–CeO2 hollow polyhedrons. When utilized as electrode materials for supercapacitors, the hybrid porous Co3O4–CeO2 hollow polyhedrons delivered a large specific capacitance of 1288.3 F g−1 at 2.5 A g−1 and a remarkable long lifespan cycling stability (<3.3 % loss after 6000 cycles). Furthermore, an asymmetric supercapacitor (ASC) device based on hybrid porous Co3O4–CeO2 hollow polyhedrons was assembled. The ASC device possesses an energy density of 54.9 W h kg−1, which can be retained to 44.2 W h kg−1 even at a power density of 5100 W kg−1, indicating its promising application in electrochemical energy storage. More importantly, we believe that the present route is a simple and versatile strategy for the preparation of other hybrid metal oxides with desired structures, chemical compositions and applications.
A Novel Application of Minimax LQG Control Technique for High‐speed Spiral Imaging
Authors: Habibullah H. , Pota H. R. , Petersen I. R. 
Published: December 2017

AbstractOver the last two decades, increasing the scanning speed of an atomic force microscopy (AFM) has been attempted either by applying novel controllers, using alternative scanning methods, or by modifying the hardware setup. This paper demonstrates, the first two approaches to achieve high‐speed AFM image scanning. A robust minimax linear quadratic Gaussian (LQG) controller is designed and spiral scanning is considered as an alternative scanning method rather than conventional raster scanning. The minimax LQG controller is designed based on an uncertain system model which is constructed by measuring the plant variations due to variations in sample mass and also modeling error between the measured and model frequency responses. This controller is also robust against uncertainties introduced as a result of variations of sample mass, spillover dynamics of the scanner at frequencies higher than the first resonance frequency of the scanner, and variation in plant transfer functions due to temperature and humidity. The designed controller is experimentally implemented on an AFM using a dSPACE ds‐1103 real‐time prototyping system and open‐loop and closed‐loop spiral imaging performances are evaluated. The proposed controller provides sufficient damping at the resonant modes to accurately track the sinusoidal reference signal and generate vibration free images. Also, creep, hysteresis, and cross‐coupling effects are significantly reduced. The experimental results show that the proposed scheme outperforms the open‐loop case and some other existing approaches.
Implementing and evaluating early intervention for children with autism: Where are the gaps and what should we do?
Authors: Vivanti Giacomo , Kasari Connie , Green Jonathan , Mandell David , Maye Melissa , Hudry Kristelle 
Published: December 2017

Despite recent advances, the evidence base supporting early intervention for young children with autism spectrum disorder (ASD) remains relatively sparse. The International Society for Autism Research (INSAR) recently sponsored a Special Interest Group (SIG) on Implementing and Evaluating Community‐Based Early Intervention. Across three meetings, in 2015, 2016, and 2017, conveners of this SIG engaged >200 members to identify knowledge gaps and research priorities for moving the field forward. Here, we summarize the perspectives that emerged from group discussion at the SIG meetings as represented by scholars working actively in the field. Despite encouraging progress, critical gaps and research priorities were identified across all the stages of intervention development and testing from conceptualization to community implementation. Key issues include the need for (a) formal theories to guide early intervention development, evaluation, and implementation; and alignment of intervention goals with scientific knowledge and societal changes that have occurred in the decades since interventions were originally developed; (b) increased focus on feasibility of treatment procedures and alignment with stakeholder values during pilot evaluations; (c) use of research designs that allow for comparisons of different interventions and formats, analyses of active ingredients of treatment, and identification of moderators and mediators of outcome; (d) use of community‐partnered participatory research to guide adaptation of intervention models to community settings; (e) inclusion of constructs related to implementation processes and outcomes in treatment trials and; (f) an iterative approach to the progression of knowledge from intervention development to implementation. Autism Res 2018, 11: 16–23. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryIn this article, we summarize the themes discussed at the INSAR Special Interest Group (SIG) on Implementing and Evaluating Community‐Based Early Intervention. Priorities for moving the field forward identified in the SIG included the need for (a) formal theories to guide the development and evaluation of interventions, (b) pilot evaluations that investigate feasibility and acceptability of interventions, (c) methodologies that allow us to determine for whom different interventions bring most benefit and why this is so, (d) strategies to include community members and other stakeholders in the process of developing and evaluating interventions, and (e) understanding of factors that make interventions more likely to be adopted and successfully implemented in the real world.
Global biomass trade for energy – Part 1: Statistical and methodological considerations
Authors: Proskurina Svetlana , Junginger Martin , Heinimö Jussi , Vakkilainen Esa 
Published: December 2017

AbstractMany countries have limited, low‐cost biomass resources to satisfy their own demand for bioenergy. International trade of biomass in various solid and liquid forms is consequently increasing. The aim of this study is to present a quantitative overview of the development of international biomass trade for energy purposes, including a discussion of methodological issues. The paper focuses on the production, export, and import of solid and liquid biofuels, including industrial roundwood, wood chips, fuel wood, wood pellets, biodiesel, and bioethanol. The study highlights changes in trends that have occurred over the past decade. Trade on global bioenergy markets is increasing: total trade of biomass for energy purposes is estimated as having increased twofold from around 780 PJ in 2004 to 1250 PJ in 2015. Despite the importance of the bioenergy market and the growth of biomass trade for energy, accurate evaluation of energy‐related biomass trade faces several methodological challenges, such as uncertainties in international statistics, inconsistent data regarding export and import volumes, as well as limited information about the final use of traded products. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd
A Systematic Scoping Review of the Choice Architecture Movement: Toward Understanding When and Why Nudges Work
Authors: Szaszi Barnabas , Palinkas Anna , Palfi Bence , Szollosi Aba , Aczel Balazs 
Published: December 2017

AbstractIn this paper, we provide a domain‐general scoping review of the nudge movement by reviewing 422 choice architecture interventions in 156 empirical studies. We report the distribution of the studies across countries, years, domains, subdomains of applicability, intervention types, and the moderators associated with each intervention category to review the current state of the nudge movement. Furthermore, we highlight certain characteristics of the studies and experimental and reporting practices that can hinder the accumulation of evidence in the field. Specifically, we found that 74% of the studies were mainly motivated to assess the effectiveness of the interventions in one specific setting, while only 24% of the studies focused on the exploration of moderators or underlying processes. We also observed that only 7% of the studies applied power analysis, 2% used guidelines aiming to improve the quality of reporting, no study in our database was preregistered, and the used intervention nomenclatures were non‐exhaustive and often have overlapping categories. Building on our current observations and proposed solutions from other fields, we provide directly applicable recommendations for future research to support the evidence accumulation on why and when nudges work. Copyright © 2017 John Wiley & Sons, Ltd.
Learning to Decide with and without Reasoning: How Task Experience Affects Attribute Weighting and Preference Stability
Authors: Leisti Tuomas , Häkkinen Jukka 
Published: December 2017

AbstractCertain experiments have shown that reasoning may weaken the stability of people's preferences, especially with regard to well‐learned perceptual judgment and decision‐making tasks, while learning has an opposite, consistency‐enhancing effect on preferences. We examined the effects of these factors in a visual multi‐attribute decision‐making task where reasoning, in contrast, has been found to benefit judgments by making them more stable. The initial assumption in this study was that this benefit would be typical for novel tasks, like the one employed here, and that it would decrease when the task is thoroughly learned. This assumption was examined in three experiments by contrasting it with an alternative assumption that this previously obtained beneficial effect is caused solely by learning, not by reasoning. It was found that learning indeed makes preferences more stable by consolidating the weights of the attributes. Reasoning, however, does not benefit this task when it is completely novel but facilitates learning and stability of the preferences long run, therefore increasing the consistency of the participants in the macrolevel. Copyright © 2017 John Wiley & Sons, Ltd.
Effects of computer‐aided instruction on the implementation of the MSWO stimulus preference assessment
Authors: Arnal Wishnowski Lindsay , Yu C.T. , Pear Joseph , Chand Carly , Saltel Lilian 
Published: December 2017

This study evaluated a self‐instructional online training package to teach students and staff to conduct a stimulus preference assessment using the multiple‐stimulus without replacement procedure. The training package included a self‐instructional manual and video modeling and was delivered online. Training was evaluated using a multiple‐probe design across a total of six university students and four staff members. Overall, students improved from a mean of 35% correct in baseline to a mean of 94% correct following training, and staff improved from a mean of 23% correct in baseline to a mean of 87% correct following training. During retention and generalization simulated assessments conducted from 7 to 17 days following training, all participants performed considerably above baseline. The online delivery of the self‐instructional manual plus video modeling has tremendous potential for providing an effective method for teaching individuals to conduct stimulus preference assessments without face‐to‐face instruction.
Jack Aviv and brains of children
Authors: Lamola Angelo A. 
Published: December 2017

AbstractBoth lead intoxication in early childhood and deficient bilirubin‐binding capacity (BBC) of blood in jaundiced neonates indicate risk for brain damage. Zinc protoporphyrin (ZPP) is a biomarker for lead intoxication (PbI) as well as well as for iron deficiency. Under the leadership of Jack Aviv, Aviv Biomedical, Inc. developed robust hematofluorometers for point‐of‐care assays of ZPP in blood and for the high‐affinity BBC of blood. These assays use just drops of whole blood and are simple, fast and inexpensive. ZPP by hematofluorometry has been used world‐wide as a primary screen for lead intoxication since 1979. Recent clinical studies enabled by an Aviv Biomedical, Inc. bilirubin hematofluorometer have renewed interest in BBC‐based assessment of neurotoxicity for improved management of neonatal jaundice. This article sketches Jack Aviv's contribution to the development and application of hematofluorometry.
Paramagnetism in Bacillus spores: Opportunities for novel biotechnological applications
Authors: Xu Zhou Ke , Ionescu Adrian , Wan Eamon , Ho Yeuk N. , Barnes Crispin H.W. , Christie Graham , Wilson D. Ian 
Published: December 2017

AbstractSpores of Bacillus megaterium, Bacillus cereus, and Bacillus subtilis were found to exhibit intrinsic paramagnetic properties as a result of the accumulation of manganese ions. All three Bacillus species displayed strong yet distinctive magnetic properties arising from differences in manganese quantity and valency. Manganese ions were found to accumulate both within the spore core as well as being associated with the surface of the spore. Bacillus megaterium spores accumulated up to 1 wt.% manganese (II) within, with a further 0.6 wt.% adsorbed onto the surface. At room temperature, Bacillus spores possess average magnetic susceptibilities in the range of 10−6 to 10−5. Three spore‐related biotechnological applications—magnetic sensing, magnetic separation and metal ion adsorption—were assessed subsequently, with the latter two considered as having the most potential for development.
Vitamin B12 association with mAbs: Mechanism and potential mitigation strategies
Authors: Du Cheng , Martin Robert , Huang Yunping , Borwankar Ameya , Tan Zhijun , West Jay , Singh Nripen , Borys Michael , Ghose Sanchayita , Ludwig Richard , Tao Li , Li Zheng Jian 
Published: December 2017

AbstractProcess control for manufacturing biologics is critical for ensuring product quality, safety, and lot to lot consistency of therapeutic proteins. In this study, we investigated the root cause of the pink coloration observed for various in‐process pools and drug substances in the antibody manufacturing process. Vitamin B12 is covalently bound to mAbs via a cobalt‐sulfur coordinate bond via the cysteine residues. The vitamin B12 was identified to attach to an IgG4 molecule at cysteine residues on light chain (Cys‐214), and heavy chain (Cys‐134, Cys‐321, Cys‐367, and Cys‐425). Prior to attachment to mAbs, the vitamin B12 needs to be in its active form of hydroxocobalamin. During culture media preparation, storage and cell culture processing, cyanocobalamin, the chemical form of vitamin B12 added to media, is converted to hydroxocobalamin by white fluorescence light (about 50% degradation in 11–14 days at room temperature and with room light intensity about 500–1,000 lux) and by short‐wavelength visible light (400–550 nm). However, cyanocobalamin is stable under red light (wavelength >600 nm) exposure and does not convert to hydroxocobalamin. Our findings suggests that the intensity of pink color depends on concentrations of both free sulfhydryl groups on reduced mAb and hydroxocobalamin, the active form of vitamin B12. Both reactants are necessary and neither one of them is sufficient to generate pink color, therefore process control strategy can consider limiting either one or both factors. A process control strategy to install red light (wavelength >600 nm) in culture media preparation, storage and culture processing areas is proposed to provide safe light for biologics and to prevent light‐induced color variations in final products.
Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
Authors: Ke Rong , Xu Qicao , Li Cong , Luo Lingyu , Huang Deqiang 
Published: December 2017

AbstractAMP‐activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy balance by decreasing the ATP‐consuming processes such as transcription of synthetic fat genes and rRNA, the translation of ribosomal proteins, synthesis of cholesterol and fatty acid, while the metabolic pathways such as glucose and fatty transport, fatty acid oxidation, autophagy, mitochondrial synthesis and oxidative metabolism are increased to preserve ATP during energy deficiency. Recent advance has demonstrated that AMPK activity has a close association with the initiation and progression in various cancers. Here we review the mechanisms that AMPK controls energy metabolism through regulating ATP synthesis and consumption, and further discuss the deregulation of AMPK in cancers.
Modified jailed balloon technique for bifurcation lesions
Authors: Saito Shigeru , Shishido Koki , Moriyama Noriaki , Ochiai Tomoki , Mizuno Shingo , Yamanaka Futoshi , Sugitatsu Kazuya , Tobita Kazuki , Matsumi Junya , Tanaka Yutaka , Murakami Masato 
Published: December 2017

AbstractObjectivesWe propose a new systematic approach in bifurcation lesions, modified jailed balloon technique (M‐JBT), and report the first clinical experience.BackgroundSide branch occlusion brings with a serious complication and occurs in more than 7.0% of cases during bifurcation stenting.MethodsA jailed balloon (JB) is introduced into the side branch (SB), while a stent is placed in the main branch (MB) as crossing SB. The size of the JB is half of the MB stent size. While the proximal end of JB attaching to MB stent, both stent and JB are simultaneously inflated with same pressure. JB is removed and then guidewires are recrossed. Kissing balloon dilatation (KBD) and/or T and protrusion (TAP) stenting are applied as needed.ResultsBetween February 2015 and February 2016, 233 patients (254 bifurcation lesions including 54 left main trunk disease) underwent percutaneous coronary intervention (PCI) using this technique. Procedure success was achieved in all cases. KBD was performed for 183 lesions and TAP stenting was employed for 31 lesions. Occlusion of SV was not observed in any of the patients. Bench test confirmed less deformity of MB stent in M‐JBT compared with conventional‐JBT.ConclusionsThis is the first report for clinical experiences by using modified jailed balloon technique. This novel M‐JBT is safe and effective in the preservation of SB patency during bifurcation stenting.
Ambulatory central VA‐ECMO with biventricular decompression for acute cardiogenic shock
Authors: Rao Prashant , Alouidor Benjamin , Smith Richard , Khalpey Zain 
Published: December 2017

AbstractWe describe the off‐pump insertion of a biventricular assist device with extra‐corporeal membrane oxygenation (ECMO): a novel technique that allows for ambulatory central veno‐arterial (VA) ECMO with direct biventricular decompression.
Septal reduction therapy using nonalcohol agent in hypertrophic obstructive cardiomyopathy: Single center experience
Authors: Asil Serkan , Kaya Barış , Canpolat Uğur , Yorgun Hikmet , Şahiner Levent , Çöteli Cem , Arat Anıl , Aytemir Kudret 
Published: December 2017

AbstractAimsPercutaneous septal reduction therapy by either alcohol or nonalcohol agents is an alternative approach to surgery in drug‐refractory symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). Nonalcohol agents have some advantages and disadvantages over alcohol during the procedure. Nowadays, a novel non‐alcohol agent, named as Ethylene‐vinyl alcohol (EVOH) copolymer (Onyx® and Squid®), is used during septal ablation. Thus, in this study, we aimed to evaluate both acute and long‐term efficacy and safety profile of EVOH during septal ablation in HOCM.Methods and resultsA total of 25 patients (52% female; mean age: 55.8 ± 17.1 years) with symptomatic HOCM were enrolled in the study. All subjects underwent clinical and laboratory assessment before and after the procedure. Peak left ventricular outflow tract (LVOT) gradient was significantly reduced just after the procedure (68 vs. 20 mmHg; P < 0.001). Peak serum creatine kinase‐myocardial band and troponin I levels were 112 (35–282) ng/ml and 11 (4–93) ng/ml. EVOH embolization to diagonal artery was observed in 1 patient (4%) and the complete atrioventricular block was noted in 2 (8%) patients. During the 12‐month follow‐up, there was no mortality. There was a significant improvement in New York Heart Association functional class of the subjects P < 0.001). Both interventricular septum thickness and LVOT gradient showed a significant reduction during follow‐up (P < 0.05). However, there was no reduction in the LVOT gradient of 3 patients (12%).ConclusionsIn conclusion, our small‐sized preliminary study results showed that septal reduction therapy using EVOH is an effective alternative option in reducing symptoms and LVOT gradient in HOCM.
Rotational atherectomy and new‐generation drug‐eluting stent implantation
Authors: Hachinohe Daisuke , Kashima Yoshifumi , Kanno Daitaro , Kobayashi Ken , Sugie Takuro , Kaneko Umihiko , Tadano Yutaka , Watanabe Tomohiko , Shitan Hidemasa , Fujita Tsutomu 
Published: December 2017

AbstractObjectivesThe aim of this study was to evaluate the clinical outcomes of rotational atherectomy (RA) followed by new‐generation drug‐eluting stent (DES) implantation in patients with an extensive amount of calcified and fibrotic plaque.BackgroundRA followed by new‐generation DES implantation for complex lesions has not been thoroughly evaluated.MethodsA total of 744 consecutive patients (770 lesions) treated with new‐generation DES implantation following RA for de novo lesions between January 2013 and November 2015 were retrospectively identified using our institutional database. Clinical outcomes at 12 months were evaluated and the independent predictors of all‐cause death and target vessel failure (TVF) were assessed using Cox regression models.ResultsTarget lesion revascularization occurred in 22 lesions (2.9%) and TVF occurred in 51 lesions (6.6%). In a multivariate analysis, hemodialysis, non‐ST‐segment elevation acute coronary syndrome, low ejection fraction, and HbA1c ≧ 7% were associated with 12‐month mortality. Hemodialysis and right coronary artery were identified as independent predictors of TVF (hazard ratio (HR) 4.107, 95% confidence interval (CI) 2.194‐7.685, P < .001; HR 2.491, 95% CI 1.023‐6.062, P = .044, respectively).ConclusionsA good debulking with RA followed by new‐generation DES implantation is recommended for patients with an excessive amount of calcified and fibrotic plaque, as this will likely improve the clinical outcomes.
Liposomal bupivacaine for the management of postsurgical donor site pain in patients with burn injuries: a case series from two institutions
Authors: Dissanaike Sharmila , McCauley Jayne , Alphonso Carlo 
Published: December 2017

Key Clinical MessageDonor site pain associated with skin graft procedures is frequently intense and difficult to treat. Liposomal bupivacaine, a prolonged‐release local anesthetic indicated for single‐dose administration to produce postsurgical analgesia, may be a viable option in managing donor site pain.
Hashimoto's encephalopathy – presenting with epilepsia partialis continua and a frontal lobe lesion
Authors: Rukmangadachar Lokesh A. , Dandapat Sudeepta , Bit‐Ivan Esther N. , Peng Yen‐Yi 
Published: December 2017

Key Clinical MessageWe report a case of Hashimoto's encephalopathy (HE), who presented with epilepsia partialis continua (EPC) and a frontal lobe lesion. The diagnosis of HE remained elusive until the serum thyroid antibodies became positive 7 months after the onset of EPC. The histopathology of this frontal lesion showed nonvasculitic inflammation.