bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling
Authors: Mamand Sami , Liu Heather , Kashem Mohammad , Martin Alberto 
Published: October 2024

Abstract
Abs play a pivotal role in adaptive immunity by binding to pathogens and initiating immune responses against infections. Processes such as somatic hypermutation and class switch recombination (CSR) enhance Ab affinity and effector functions. We previously carried out a CRISPR/Cas9 screen in the CH12F3-2 (CH12) lymphoma B cell line to identify novel factors involved in CSR. The screen showed that guide RNAs targeting both Rasa2 and Rasa3 genes were decreased in IgA-negative CH12 B cells, implying that these genes might suppress CSR. Indeed, CSR was increased when either Rasa2 or Rasa3 were knocked out in CH12 cells. Compared to controls, Rasa2−/− and Rasa3−/− CH12 cells had increased expression of activation-induced cytidine deaminase (AID) and Iα transcripts, providing an explanation for the increased CSR. The increased CSR, AID, and Iα expression in Rasa2−/− or Rasa3−/− CH12F3-2 is mediated through TGF-β stimulation. Indeed, we found that deletion of RASA2 or RASA3 promotes a shift from noncanonical to canonical TGF-β signaling through SMAD3. These results show that RASA2 and RASA3 are both novel regulators of TGF-β signaling in B cells, a pathway known to be essential for CSR to IgA.
Exploring work engagement of public sector employees during the COVID-19 pandemic, Namibia
Authors: Ingo Selma N. , Pieters Wesley R. 
Published: October 2024

Orientation: In Namibia, the public sector employs a majority of employees which contributes to significant economic growth and development of the country.Research purpose: This study investigated the association among job satisfaction, burnout and work engagement. This study explored if work engagement is experienced differently based on the biographical variables.Motivation for the study: Namibia aims to achieve the sustainable development goals (SDGs), Harambee Prosperity Plan (HPP) and National Development Goals. The state-owned enterprises are required to provide quality services to the nation through their employees. The health and well-being of these employees facilitate the productivity of these state-owned enterprises (SDGs 1, 2, 3, 8, 11 and 16).Research approach/design and method: A total of n = 130 public sector employees were randomly selected and responded to a questionnaire. The questionnaire included demographic questions, the Job Satisfaction Survey, the Maslach Burnout Inventory and the Utrecht Work Engagement Scale. Data analysis was performed through the Statistical Package for Social Sciences software to test the hypotheses of the study.Main findings: Positive relationships were found between job satisfaction, burnout and work engagement. Work engagement reported a positive relationship with burnout. Work engagement is experienced the same in relation to the biographical variables.Practical/managerial implications: The study suggests a constant evaluation of job attitudes, implementation of effective performance management systems, team building activities and implementation of workplace wellness programmes.Contribution/value-add: This study adds to the understanding of job satisfaction, burnout and work engagement within state-owned enterprises in Namibia.
Die Funktion des מַלְאָךְ in Hiob 33,23–24
Authors: Erhardt Timon , Wünch Hans-Georg 
Published: October 2024

The function of מַלְאָךְ in Job 33:23–24. In his first speech in the Book of Job (Job 32:6b–33:33), Elihu addresses, among other things, the God-ordained upbringing of human beings (33:14–30). In addition to dreams and visions (33:15–18), persistent pain can also educate people (33:19–22). In describing this education, Elihu surprisingly mentions a מַלְאָךְ [messenger, angel] who appears and mediates between God and the person who is suffering (33:23–24). As this passage presents some difficulties on text-critical, grammatical, and semantic levels, the role of the מַלְאָךְ has been interpreted differently by commentators to date. This article deals with the question of what function the מַלְאָךְ takes on in Job 33:23–24. The aim is to offer a coherent solution to the textual difficulties and to define the role of the מַלְאָךְ in the educational process. Acknowledging that various possibilities can lead to different interpretations, the article presented here is that in this passage, an angel mediates between God and humans by instructing them about a godly way of life and interceding for them before God, so that they can be saved from imminent death.Intradisciplinary and/or interdisciplinary implications: This article examines an aspect of the Book of Job that has received relatively little attention in Old Testament research. It thus contributes to the discussion about the significance of Elihu’s speeches in the book.
Endoscopic and pathological features of neoplastic transformation of gastric hyperplastic polyps: Retrospective study of 4010 cases
Authors: Zhang Dong-Xue , Niu Zhan-Yue , Wang Ye , Zu Ming , Wu Ya-Han , Shi Yan-Yan , Zhang He-Jun , Zhang Jing , Ding Shi-Gang 
Published: October 2024

BACKGROUND
Hyperplastic polyps, which represent 30%-93% of all gastric epithelial polyps, are the second most common type of gastric polyps after fundic gland polyps. They were previously considered to have no risk of neoplastic transformation. Recently, an increasing number of cases of gastric hyperplastic polyps (GHPs) combined with neoplastic changes have been reported; however, the specific mechanism underlying their transformation has not been thoroughly explored.
AIM
To investigate the clinical, endoscopic, and pathological characteristics of the neoplastic transformation of GHPs and explore the risk factors.
METHODS
A retrospective analysis was performed on 4010 cases of GHPs diagnosed by gastroscopy and pathological examination at the hospital from 2005 to 2021. In total, 3874, 119, and 17 cases were in the group without intraepithelial neoplasia (IN), with low-grade IN, and with high-grade IN, respectively. The data analysis examined the association of endoscopic and pathological features with risk factors for neoplastic transformation. Factors with significant differences were entered into univariate logistic regression, followed by multivariate logistic regression analysis.
RESULTS
Univariate analysis revealed diameter, multiple polyp presence, redness, rough surface, lobulation, erosion, Yamada classification, location, and gastric mucosa were risk factors for neoplastic transformation. Multivariate analysis showed that age > 65 years [odds ratio (OR) = 1.789; 95% confidence interval (CI): 1.227-2.609; P = 0.003], male sex (OR = 1.680; 95%CI: 1.158-2.438; P = 0.006), multiple polyps (OR = 1.851; 95%CI: 1.230-2.784; P = 0.003), pedunculated or semi-pedunculated shape (OR = 2.722; 95%CI: 1.689-4.388; P < 0.001), and polyp diameter were significantly associated with GHPs that demonstrated neoplastic transformation. Compared with chronic superficial gastritis, autoimmune gastritis, atrophic gastritis, and gastritis with IN were independent risk factors for neoplastic transformation [(OR = 2.672; 95%CI: 1.559-4.579; P < 0.001), (OR = 1.876; 95%CI: 1.134-3.103; P = 0.014), and (OR = 5.299; 95%CI: 3.173–8.849; P < 0.001), respectively].
CONCLUSION
Male sex, age > 65 years, multiple polyps, pedunculated or semi-pedunculated shape, polyp size > 1 cm, and specific background gastric mucosa are key indicators for predicting neoplastic transformation of GHPs.
Exploring the interplay between emotional intelligence and academic performance of undergraduate university students
Authors: Tafa Dagne , Tefera Belay 
Published: October 2024

This study aimed to investigate the relationship between perceived emotional intelligence and students' academic achievement. To this end, a quantitative research approach with a correlational design was employed. Participants were randomly selected using a stratified sampling technique, resulting in a sample of 135 second- and third-year undergraduate psychology students. An emotional intelligence scale was administered to these participants, and the collected data were subsequently analyzed using both descriptive statistics (including mean, frequency, and percentage) and inferential statistics (including independent sample t-tests, one-way ANOVA, Pearson product-moment correlation, multiple regression analysis, and mediation analysis). The findings indicated that students' perceived emotional intelligence levels were above average. Group comparison analyses revealed that, among various socio-demographic variables, only sex showed a significant difference in emotional intelligence. Similarly, the analysis showed that only the parents’ level of education significantly impacted students’ academic performance. Furthermore, a statistically significant positive relationship was found between emotional intelligence and academic achievement. Additionally, linear multiple regression analysis revealed that emotional intelligence significantly contributed to academic performance. Mediation analysis further revealed that the relationship between emotional intelligence and academic achievement is partially mediated by sex. Finally, the study concludes with recommendations aimed at enhancing the academic achievement of students.
Mesenteric venous thrombosis in a young adult: A case report and review of the literature
Authors: Yuan Jiao-Jiao , Zhang Hai-Fu , Zhang Jian , Li Jun-Zhi 
Published: October 2024

BACKGROUND
Acute mesenteric vein thrombosis (MVT) accounts for only 2%–10% of all cases of acute mesenteric ischaemia, with an incidence rate of ~0.1% in Europe and the United States. It represents < 10% of mesenteric infarction cases and is seen predominantly in older adults. In younger individuals, MVT is uncommon, with 36% of cases having unidentified mechanisms and causes.
CASE SUMMARY
A 27-year-old man presented to the emergency department on February 29, 2024, with a chief complaint of intermittent abdominal pain for 3 day. He was previously in good health. As the abdominal pain was not alleviated by conventional treatment, an abdominal computed tomography (CT) scan was performed, which showed increased density in the portal and mesenteric veins. Further imaging, including portal vein ultrasound, mesenteric CT angiography, and enhanced abdominal CT, revealed widespread thrombosis of the portal vein system (including the main portal vein, left and right branches, proximal mesenteric vein, and splenic vein). After 10 day of thrombectomy and anticoagulation therapy, the patient’s abdominal pain had improved significantly. Follow-up assessments indicated that portal venous blood flow had largely returned to normal. He was discharged on March 9, 2024. During a follow-up exam 2 months later, repeat abdominal enhanced CT showed that the previously detected thrombi were no longer visible.
CONCLUSION
Clinicians should remain vigilant for acute MVT in young patients presenting with abdominal pain, to prevent misdiagnosis of this fatal condition.
Portal venous gas complication following coronary angiography: A case report
Authors: Yu Zhang-Xiang , Bin Zhang , Lun Zhu-Kai , Jiang Xu-Jian 
Published: October 2024

BACKGROUND
Portal vein gas (PVG) is an abnormal accumulation of gas within the portal and intrahepatic portal veins. It is associated with various abdominal diseases, ranging from benign conditions to life-threatening ones that require immediate surgical intervention. Coronary angiography is the standard diagnostic procedure for coronary artery disease. There were no prior reports are available of PVG as a complication of coronary angiography.
CASE SUMMARY
In the specific case described here, the patient did not show signs of peritoneal irritation; however, computed tomography scans findings revealed pneumatosis in the wall of the small intestine, hepatic portal vein, and mesenteric vein, along with acute enteritis (etiology pending classification). A cesarean section was not performed, and the patient received treatment with fasting, rehydration, and anti-infection therapy. Subsequently, the patient's symptoms of abdominal distension and pain improved, and follow-up computed tomography scans indicated resolution of the portal system pneumatosis and intestinal wall edema, resulting in a favorable clinical outcome.
CONCLUSION
Portal venous gas complication following coronary angiography was a complication of coronary angiography.
Chẩn đoán di truyền ở thai có dị tật tim bẩm sinh kèm theo chậm phát triển trong tử cung bằng kỹ thuật SNP Array
Authors: Nguyễn Phương Tú , Hoàng Thị Ngọc Lan , Trần Danh Cường , Nguyễn Quốc Tuấn 
Published: October 2024

Mục tiêu nghiên cứu: Chẩn đoán các bất thường di truyền ở thai có di tật tim trên siêu âm kèm theo chậm phát triển trong tử cung.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang được tiến hành trên hồ sơ bệnh án từ 08/2022 đến 09/2023 thu được 73 trường hợp thai có dị tật tim được chọc hút dịch ối để chẩn đoán trước sinh tại bệnh viện Phụ sản Trung ương phù hợp với các tiêu chuẩn lựa chọn.
Kết quả: 9 trường hợp thai chậm phát triển trong tử cung kèm dị tật tim trên siêu âm, tìm thấy có bất thường về di truyền, gồm 8 CNV (copy number variation - biến thể có bản sao) được phân loại gây bệnh, 1 CNV chưa rõ ý nghĩa lâm sàng. Các CNV bất thường tập trung chủ yếu ở hai hình thái dị tật tim là thông liên thất và tứ chứng Fallot. Trong 9 trường hợp này, SNP Array phát hiện thêm được 4 trường hợp bất thường gen, cao gấp đôi số ca có kết quả nhiễm sắc thể (NST) đồ bất thường.
Kết luận: Các thai dị tật tim bẩm sinh có chậm phát triển trong tử cung đều tìm ra có các bất thường di truyền và SNP Array có tính ưu việt cao trong chẩn đoán trước sinh ở các trường hợp này.
Một số yếu tố nguy cơ xuất huyết trong não thất ở trẻ đẻ non tại Bệnh viện Phụ sản Trung ương
Authors: Hà Thị Lương , Lê Minh Trác , Hoàng Thị Vân 
Published: October 2024

Mục tiêu: Đánh giá tỷ lệ xuất huyết trong não thất (XHTNT) và nhận xét một số yếu tố nguy cơ xuất huyết trong não thất ở trẻ đẻ non.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang 300 bệnh nhân đẻ non tại Bệnh viện Phụ sản Trung ương từ tháng 9/2023 đến tháng 3/2024.
Kết quả: Siêu âm thóp 300 bệnh nhân có 49 bệnh nhân xuất huyết trong não thất chiếm tỷ lệ 16,3%, Mức độ XHTNT độ 1: 59,2%, độ 2: 18,4%, độ 3: 12,2%, độ 4: 10,2%. Trẻ dưới 28 tuần thai (52,6%), trẻ dưới 1000 g (32,8%). Siêu âm thóp phát hiện 89,8% xuất huyết trong 7 ngày đầu. Tiêm steroid trước sinh giảm nguy cơ XHTNT (OR = 0,48, p = 0,043). Một số yếu tố tăng nguy cơ XHTNT: apgar < 7 điểm, tuổi thai < 32 tuần, cân nặng < 1500g, hỗ trợ thở máy, hạ nhiệt độ, pH < 7,2, BE < -10, PaCO2 > 55 mmHg, bệnh màng trong, chảy máu phổi, nhiễm khuẩn sơ sinh, còn ống động mạch, tiêm bicarbonat. Phân tích đa biến: apgar < 7 điểm (OR = 7,5, p = 0,01), tuổi thai < 32 tuần (OR = 5,0; p = 0,02), hỗ trợ thở máy (OR = 8,7; p = 0,03), pH < 7,2 (OR = 13,2; p < 0,001), BE < -10 (OR = 13,1; p < 0,001), PaCO2 > 55 mmHg (OR = 3,2; p = 0,002), còn ống động mạch (OR = 3,2; p = 0,002) làm tăng nguy cơ xuất huyết trong não thất.
Kết luận: Tỷ lệ XHTNT ở trẻ đẻ non khá phổ biến 16,3%, đặc biệt ở trẻ đẻ non dưới 28 tuần và dưới 1000g. Tiêm steroid trước sinh giảm nguy cơ XHTNT. Có nhiều yếu tố nguy cơ làm tăng tỷ lệ XHTNT. Phân tích đa biến: apgar < 7 điểm, tuổi thai < 32 tuần, hỗ trợ thở máy, pH < 7,2, BE < -10, PaCO2 > 55 mmHg, còn ống động mạch làm tăng nguy cơ XHTNT.
YOSHLARNING ONLAYN TA’LIM JARAYONIGA TA’SIR ETUVCHI IJOBIY SALBIY OMILLAR
Authors: Abduxolikova Nasiba 
Published: October 2024

Axborot texnologiyalari rivojlangan davrda yoshlarning masofadan turib ta’lim olishi uchun imkoniyatlar yaratildi. Istalgan vaqtda va jahonning istalgan joyida turib o‘qish imkoniyati onlayn ta’limning eng afzal jihatlaridan biridir. Maqolada onlayn ta’limning afzalliklari bilan bir qatorda kamchiliklari xam yoritilgan.
Green Supply Chain Employee Involvement on Performance of Manufacturing Firms in Nairobi County
Authors: Ngatuny Julius , Karanja Antony , Namusonge Eric , Omwenga Jane 
Published: October 2024

Purpose: The general objective of the study was to determine influence of green supply chain employee involvements on performance of manufacturing firms, in Nairobi County Kenya.
Methodology: The study was informed by Social Exchange Theory, Transaction Cost Theory, Resource-Based view and Resource Dependency Theory. The research design for this study was an explanatory survey research design; this is primarily a positivism approach. The population for the study will constitute manufacturing firms in Kenya. Thus, the unit of observation was 516 procurement managements from 516 manufacturing firms. The research employed stratified and simple random to select a sample of 225. This study used structured questionnaires to collect data relevant to the study. Descriptive analysis such as means, standard deviation and variance.
Findings: Linear regression models showed that green supply chain employee involvements have a positive and statistically significant influence on firm performance, highlighting their essential role in enhancing performance for manufacturing firms. A strong partnership with suppliers and specialized expertise in green supply chain management are crucial for this improvement.
Unique Contribution to Theory, Practice and Policy: The study recommends that organizations commit to ongoing education and engagement of their workforce. This includes regular training programs that inform employees about sustainable practices and their importance to the company's mission. Additionally, implementing recognition and reward systems for employees who innovate in sustainability can enhance engagement. Policymaking should also include mandatory training on environmental responsibility and a structured program for employees to propose green initiatives.
Evaluating the Availability and Accessibility of Agricultural Extension Services Under the Single Spine System in Uganda. A Case of Smallholder Crop Farmers in Buhweju District
Authors: Nimushaba Patience , Waiswa Jeremy 
Published: October 2024

Purpose: This study evaluated the availability and accessibility of agricultural extension services under the Single Spine System, with a specific focus on smallholder crop farmers in Buhweju District.
Methodology: The study adopted a mixed-methods approach, employing both quantitative and qualitative data collection techniques. Structured questionnaires were administered to a sample of 393 smallholder crop farmers and key informant interviews with district agricultural officers and extension workers provided in-depth insights into the delivery of services.
Findings: The results indicate that education was positively and significantly (P<0.01) associated with knowledge about the availability of extension services. Farmers with more years of schooling had a greater likelihood of being aware of extension providers. Similarly, larger households with more labor resources (median size = 4) had better access to extension services. Moreover, household land size (median = 3 acres) and income (median = UGX 250,000) were significantly correlated with both availability and access to extension services, with wealthier farmers seeking more information to improve agricultural productivity. The study also revealed that proximity to extension service centers was a critical factor; households closer to sub-county offices (median distance = 1.5 km) had higher knowledge of available services. Access to credit and group membership were also major determinants of both awareness and access to extension services. Challenges were also identified, including limited outreach by extension officers, inadequate allowances, and insufficient logistical support for field officers.
Unique Contribution to Theory, Policy and Practice: The study recommends increased sensitization efforts using local leaders, social media, and community networks, alongside greater support for sub-county agricultural officers to ensure effective service delivery.
Fine-Root Responses of Two Maple and Two Magnolia Species to Waterlogging
Authors: Patrick Kelsey , Lo Marvin , Rigsby Chad M. , Rosenfeld Carla E. , McCormack M. Luke 
Published: October 2024

AbstractBackgroundUrban trees provide many environmental benefits but often face challenging growing conditions like waterlogged soils. How tree root systems respond to waterlogging impacts tree performance and survival, yet this has received little attention. Our goal was to identify how the roots of temperate urban tree species respond and recover to waterlogging.MethodsWe monitored the responses and recovery of 2 contrasting maple and magnolia species pairs that differ in their reported waterlogging tolerance to a 2-week waterlogging period, measuring belowground stress indicators, fine-root mortality, and aboveground responses including leaf-level photosynthesis, leaf loss, and stem growth.ResultsThough silver maple experienced a temporary reduction in photosynthetic activity during waterlogging, it exhibited no fine-root mortality, and photosynthetic activity recovered after a 10-day recovery period. In contrast, sugar maple showed high fine-root mortality, decreased photosynthetic activity, and significant leaf loss, with no recovery in fine-root growth or photosynthetic activity after the recovery period. Both magnolia species showed high fine-root mortality and reduced photosynthesis during the waterlogging period. However, after the 10-day recovery period, both magnolias also showed new fine-root growth and increased photosynthetic activity.ConclusionThe species studied here showed a wide range of fine-root response and recovery strategies to waterlogging, and this was mirrored in their aboveground performance. Future work clarifying the mechanisms driving these different strategies, such as silver maple’s ability to maintain fine roots and mitigate internal tissue damage, will help us to further understand species differences in waterlogging tolerance and better inform urban tree selection for repeatedly flooded soils.
Application of Artificial Intelligence on Library System, Operations and Services
Authors: Samanta Ranjan , Das Biswajit 
Published: October 2024

This paper is going to aware in the field of Artificial Intelligence focusing on how it’s applied in the Library world. The concept such as machine learning, deep learning and their various applications by Technique is enumerated. In this paper an attempt has been made to identify the different applications of Artificial Intelligence into the libraries. The various concepts such as expert system, natural language processing, pattern recognition and robotics and their application to the library operation and services have been explained thoroughly. The advantages and disadvantages of Artificial Intelligence have also been discussed.
The utility of Blogs as a Tool for Online Services of Small Libraries
Authors: Kumar Ajay , Kishore Amit , Singh Akash Kumar 
Published: October 2024

The way and circumstances have changed in the COVID-19 era. It is why effective and reliable online library services has become essential for every library, but providing online services especially for small libraries is relatively difficult and blogs have emerged as an effective tool for online services by small libraries. The present paper explores the concept, types of blogs, some of the major open source blogging tools and its utility in library services