bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of a biotechnological multiproduct batch plant design for the manufacture of four different products: A real case scenario
Authors: Sandoval Gabriela , Espinoza Daniel , Figueroa Nicolas , Asenjo Juan A. 
Published: February 2017

ABSTRACTIn this work a biotechnological multiproduct batch plant that manufactures four different recombinant proteins for human application is described in some detail. This batch plant design is then optimized with regards to the size of equipment using a mixed‐integer linear programming (MILP) formulation recently developed by us in order to find a hypothetical new biotechnological batch plant based on the information of real known processes for the production of the four recombinant protein products. The real plant was divided for practical purposes into two sub‐processes or facilities: a fermentation facility and a purification facility. Knowing the specific steps conforming the downstream processing of each product, size, and time factors were computed and used as parameters to solve the aforementioned MILP reformulation. New constraints were included to permit the selection of some equipment—such as centrifuges and membrane filters—in a discrete set of sizes. For equipment that can be built according to customer needs—such as reactors—the original formulation was retained. Computational results show the ability of this optimization methodology to deal with real data giving reliable solutions for a multi‐product batch plant composed of 44 unit operations in a relatively small amount of time showing that in the case studied it is possible to save up to a 66% of the capital investment in equipment given the cost data used. Biotechnol. Bioeng. 2017;114: 1252–1263. © 2017 Wiley Periodicals, Inc.
Procedural and 30‐day clinical outcomes following transcatheter aortic valve replacement with lotus valve: Results of the RELEVANT study
Authors: Montone Rocco A. , Testa Luca , Fraccaro Chiara , Montorfano Matteo , Castriota Fausto , Nerla Roberto , Angelillis Marco , Tusa Maurizio , Giannini Francesco , Garatti Andrea , Tarantini Giuseppe , Petronio Anna Sonia , Brambilla Nedy , Bedogni Francesco 
Published: February 2017

ObjectivesWe report procedural and 30‐day clinical outcomes following transcatheter aortic valve replacement (TAVR) with Lotus Valve system in a high‐risk population.BackgroundLotus valve is a second‐generation TAVR fully repositionable and retrievable device. RELEVANT (REgistry of Lotus valvE for treatment of aortic VAlve steNosis with Tavr) study is an Italian prospective multicentre registry.MethodsFive major centers performing TAVR using Lotus participated. All high‐risk symptomatic patients with severe aortic stenosis were evaluated by a heart team and screened for eligibility for TAVR. Primary end‐points were procedural and 30‐day mortality. Secondary endpoints included procedural and 30‐day safety/effectiveness metrics according to Valve Academic Research Consortium (VARC)−2 criteria.ResultsTwo hundred and twenty‐five patients undergoing TAVR with Lotus were enrolled. Mean age was 82.6 ± 6.3 years, 51.6% females. Mean STS score for mortality was 8.3 ± 5.6. Procedural success was achieved in 98.7% of patients. All‐cause mortality was 2.2% at discharge and 2.7% at 30‐day. Stroke rate was 2.2% at discharge and 3.1% at 30‐day. Patients requiring a new permanent pacemaker implantation were 30.7% at discharge and 31.8% at 30‐day. Paravalvular regurgitation (PVR) was trace/mild in 99.1% of patients at discharge. Only two patients (0.9%) had moderate PVR at discharge and at 30‐day, whereas none had severe PVR.ConclusionsRELEVANT study showed that TAVR using Lotus, in a real‐world population of patients with severe aortic stenosis at high surgical risk, was associated with excellent device success implantation and early safety according to VARC‐2 definition. The pacemaker implantation rate was about a third of patients. © 2017 Wiley Periodicals, Inc.
Zinc phosphide poisoning with unusual radiologic findings
Authors: Nekooghadam Sayyedmojtaba , Haghighatkhah Hamidreza , Vaezi Fateme , Sanei Taheri Morteza , Moharamzad Yashar 
Published: February 2017

Key Clinical MessageAccidental/suicidal ingestion of metal phosphides (e.g., zinc phosphide found in rodenticides) should be suspected in patients with sudden‐onset abdominal pain, refractory hypotension, and metabolic acidosis. CT angiography may show radiopaque substance in the stomach and early enhancement of the inferior vena cava and contrast in right side of the heart.
Doing Good and Different! The Mediation Effect of Innovation and Investment on the Influence of CSR on Competitiveness
Authors: Marin Longinos , Martín Pedro J. , Rubio Alicia 
Published: February 2017

AbstractIn recent decades, the debate about the strategic potential of corporate social responsibility (CSR) and the existence of a possible relationship between CSR and competitiveness has become increasingly relevant. However, the literature has not analysed in detail why this influence occurs and what the key elements that determine increasing competitiveness are. This study analyses the roles of innovation and investment in the ways in which CSR influences competitiveness. The results from an empirical study of 236 companies show no direct influence of CSR on competitiveness, but innovation and investment are shown to affect CSR's influence on competitiveness indirectly and significantly. These results demonstrate a total mediation effect of innovation and investment on CSR's influence on competitiveness. The theoretical and practical implications of this study are discussed together with its limitations and potential for future research. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Dual Heteroatom‐Doped Carbon Nanofoam‐Wrapped Iron Monosulfide Nanoparticles: An Efficient Cathode Catalyst for Li–O2 Batteries
Authors: Ramakrishnan Prakash , Shanmugam Sangaraju , Kim Jae Hyun 
Published: February 2017

AbstractCost‐effective dual heteroatom‐doped 3D carbon nanofoam‐wrapped FeS nanoparticles (NPs), FeS‐C, act as efficient bifunctional catalysts for Li–O2 batteries. This cathode exhibits a maximum deep discharge capacity of 14 777.5 mA h g−1 with a 98.1 % columbic efficiency at 0.1 mA cm−2. The controlled capacity (500 mA h g−1) test of this cathode delivers a minimum polarization gap of 0.73 V at 0.1 mA cm−2 and is sustained for 100 cycles with an energy efficiency of approximately 64 % (1st cycle) and 52 % (100th cycle) at 0.3 mA cm−2, under the potential window of 2.0–4.5 V. X‐ray photoelectron spectroscopy reveals the substantial reversible formation and complete decomposition of Li2O2. The excellent recharging ability, high rate performance, and cycle stability of this catalyst is attributed to the synergistic effect of FeS catalytic behavior and textural properties of heteroatom‐doped carbon nanostructures.
Resource optimization for emulation of behavioral models of mixed signal circuits on FPGA: a case study of DC–DC buck converter
Authors: Bhattacharya Rahul , Kumar Subindu , Biswas Santosh 
Published: February 2017

SummaryThis paper presents a semi‐automated word‐length optimization framework to reduce field‐programmable gate array (FPGA) resource utilization for FPGA‐based pre‐silicon test emulation of analog and mixed signal circuits while achieving the desired accuracy and overcoming long optimization time. Although high‐level behavioral models exist for modeling analog and mixed signal circuits, these comprise many complex differential equations which cannot be realized implicitly using Boolean logic (which is the basic functional block of an FPGA) on an FPGA. So, a more convenient way is explored to map analog circuits into digital domain by converting them into fixed‐point architectures because of its advantage of manipulating data with lower word‐length. To address the loss of accuracy due to finite word‐length effects and limited reconfigurable resources, word‐lengths are optimized under the constraint of given performance metrics. The proposed technique built in MATLAB/Simulink environment with Xilinx System Generator support is illustrated with the help of a case study of a peak‐current‐mode‐controlled buck‐type switching converter implemented on Xilinx Virtex™‐5 FPGA. To illustrate the applicability of this environment for pre‐silicon test development, well‐accepted fault models are emulated with the help of non‐ideal model of a buck converter. The emulation results are seen to be close to that of a post‐fabricated power converter in the presence of faults. Experimental results show that FPGA resource utilization can be reduced significantly while achieving the desired performance accuracy under the constraint of multiple error metrics. Copyright © 2017 John Wiley & Sons, Ltd.
Blown by the wind: the ecology of male courtship display behavior in orchid bees
Authors: Pokorny Tamara , Vogler Ira , Losch René , Schlütting Patrick , Juarez Pedro , Bissantz Nicolai , Ramírez Santiago R. , Eltz Thomas 
Published: February 2017

AbstractMany insects rely on chemical signals to transmit precise information on the location, identity, and quality of potential mates. Chemical signals are often broadcasted at sites with physical properties that maximize signal propagation and signal transmission. Male neotropical orchid bees (Euglossini) perch and display on vertical branches and tree trunks in the forest to expose volatile blends (perfumes) that they previously collected from their environment. Previous studies have shown that the chemical composition of perfume blends is highly differentiated even between closely related species. However, variation in behavioral components of perfume exposure and male display remain poorly understood. We conducted a four‐year study on orchid bee display sites (8 species) in pacific Costa Rica, using field observations along with chemical analysis and cage experiments to assess display niche partitioning among sympatric species. We evaluated the influence of physical factors (terrain, wind, light) on the distribution of perch sites and on display behavior, and tested a prediction of the sex pheromone‐analogue hypothesis, i.e., that displaying males have above‐average quantities or qualities of acquired perfumes. Males of different species displayed in the same general area and sometimes in close proximity to each other, but partitioned the display niche by selecting different perch diameters, display heights, and by displaying at different times of the day. Most perch sites were located inside the forest on elevated ground, especially along ridges, where stronger winds may help disperse perfume signals. Furthermore, the angular position of displaying males on perches was narrowly determined by wind direction, with males being positioned on the downwind side of the perch, where they would be most conspicuous to conspecifics approaching on an odor trail. Although our results generally support the hypothesis that perfumes serve as pheromone analogues, we did not find differences in the perfume composition of males caught at display perches and males captured at chemical baits. This suggests that, while chemical communication is an integral part of orchid bee display, male display activity is not determined by the history of, and success in, volatile acquisition.
Seasonality and predictability shape temporal species diversity
Authors: Tonkin Jonathan D. , Bogan Michael T. , Bonada Núria , Rios‐Touma Blanca , Lytle David A. 
Published: February 2017

AbstractTemporal environmental fluctuations, such as seasonality, exert strong controls on biodiversity. While the effects of seasonality are well known, the predictability of fluctuations across years may influence seasonality in ways that are less well understood. The ability of a habitat to support unique, non‐nested assemblages of species at different times of the year should depend on both seasonality (occurrence of events at specific periods of the year) and predictability (the reliability of event recurrence) of characteristic ecological conditions. Drawing on tools from wavelet analysis and information theory, we developed a framework for quantifying both seasonality and predictability of habitats, and applied this using global long‐term rainfall data. Our analysis predicted that temporal beta diversity should be maximized in highly predictable and highly seasonal climates, and that low degrees of seasonality, predictability, or both would lower diversity in characteristic ways. Using stream invertebrate communities as a case study, we demonstrated that temporal species diversity, as exhibited by community turnover, was determined by a balance between temporal environmental variability (seasonality) and the reliability of this variability (predictability). Communities in highly seasonal mediterranean environments exhibited strong oscillations in community structure, with turnover from one unique community type to another across seasons, whereas communities in aseasonal New Zealand environments fluctuated randomly. Understanding the influence of seasonal and other temporal scales of environmental oscillations on diversity is not complete without a clear understanding of their predictability, and our framework provides tools for examining these trends at a variety of temporal scales, seasonal and beyond. Given the uncertainty of future climates, seasonality and predictability are critical considerations for both basic science and management of ecosystems (e.g., dam operations, bioassessment) spanning gradients of climatic variability.
Psychiatric comorbidity in new daily persistent headache: A cross‐sectional study
Authors: Uniyal R. , Paliwal V. K. , Tripathi A. 
Published: February 2017

AbstractBackgroundNew daily persistent headache (NDPH) is a type of chronic daily headache. NDPH can have migrainous (NDPH‐CM) or tension‐type character (NDPH‐CTTH). Recently, NDPH patients have shown to have associated anxiety and depression. We compared anxiety, depressive symptoms, somatization and pain catastrophization among NDPH, healthy controls and patients with chronic low‐back pain and between NDPH‐CM and NDPH‐CTTH.MethodsWe assessed the study population for depressive symptoms by Patient Health Questionnaire‐9, anxiety by Generalized Anxiety Disorder Scale – 7, somatoform disorder using DSM IV (TR) criteria and pain catastrophizing by using Pain Catastrophizing Scale.ResultsFifty‐five patients each with NDPH (mean age 28.24 ± 12.05 years, 45.5% females) and age/sex matched healthy individuals and patients with chronic low‐back pain were enrolled. Among NDPH patients, somatoform disorder was seen in 32.7%, severe anxiety in 65.5%, severe depressive symptoms in 40%, significant pain catastrophization in 85.5%. NDPH patients had significantly higher frequency of all psychiatric co‐morbidities as compared to healthy controls and patients with chronic low‐back pain. NDPH‐CM patients had significantly higher frequency of depression and pain catastrophizing behaviour as compared to NDPH‐CTTH.ConclusionAnxiety, depressive symptoms, somatization and pain catastrophizing were significantly more prevalent in NDPH when compared to healthy individuals and patients with chronic low back pain. Such effects should be sought for, as they might contribute to refractoriness to treatment.SignificanceAnxiety, depressive symptoms, somatization and pain catastrophizing were significantly more prevalent in new daily persistent headache when compared to healthy individuals and patients with chronic low back pain. Such effects should be sought for, as they might contribute to refractoriness to treatment.
Axially equilibrated displacement‐based beam element for simulating the cyclic inelastic behaviour of RC members
Authors: Tarquini Danilo , Almeida João P. , Beyer Katrin 
Published: February 2017

SummaryDistributed plasticity beam elements are commonly used to evaluate limit state demands for performance‐based analysis of reinforced concrete (RC) structures. Strain limits are often preferred to drift limits because they directly relate to damage and are therefore less dependent on member geometry and boundary conditions. However, predicting accurately strain demands still represents a major simulation challenge. Tension shift effects, which induce a linear curvature profile in the plastic hinge region of RC columns and walls, are one of the main causes for the mismatch between experimental and numerical estimates of local level quantities obtained through force‐based formulations. Classical displacement‐based approaches are instead suitable to simulate such linear curvature profile. Unfortunately, they verify equilibrium only on an average sense due to the wrong assumption on the axial displacement field, leading to poor deformation and force predictions. This paper presents a displacement‐based element in which axial equilibrium is strictly verified along the element length. The assumed transversal displacement field ensures a linear curvature profile, connecting accurately global displacement and local strain demands. The proposed finite element is validated against two sets of quasi‐static cyclic tests on RC bridge piers and walls. The results show that curvature and strain profiles for increasing ductility demands are significantly improved when axially equilibrated rather than classical displacement‐based or force‐based elements are used to model the structural members. Copyright © 2017 John Wiley & Sons, Ltd.
Serum Clara cell protein and atopic phenotype in children up to 2 years of age
Authors: Ilic Nevenka , Mihailovic Natasa 
Published: February 2017

BackgroundLow value of serum Clara cell protein (CC16) is associated with bronchial hyperreactivity in children.ObjectiveTo evaluate the serum CC16 in relation to atopy and previously manifested LRTD.MethodsIn the population of 163 healthy 5‐ to 24‐month‐old children, atopy was determined by Phadiatop‐infant (serum‐specific IgE≥0.35 kUA/L), serum CC16 by ELISA, while data on previously manifested low respiratory tract diseases (LRTD) were collected from the Health Care Center database.ResultsIn atopic children, serum CC16 negatively correlated with age (r −.281, P=.041, n=53), while in nonatopic children, this correlation was positive (r .200, P=.036, n=110). Atopic ≥8‐month‐old children with previously manifested LRTD had lower level of CC16 (3.07 ng/mL) in relation to atopic children without LRTD at the same age (6.51 ng/mL), P=.029 (value of serum CC16≥4.8 ng/mL indicates atopic phenotype without LRTD 75% sensitivity, 87.5% specificity). In 8‐ to 24‐month‐old children with previously manifested pneumonia, serum CC16 was lower in atopic (2.9 ng/mL) in relation to nonatopic children (3.7 ng/mL), P=.029 (serum CC16 ≤3.4 ng/mL indicating atopy in the group of children with pneumonia, sensitivity 100%, and specificity 77%). Atopic 8‐ to 24‐month‐old children with previously manifested pneumonia had lower CC16 in relation to other atopic children in this age (P=.021) (for cutoff CC16≤3.4 ng/mL sensitivity 100%, specificity 77%), and also often chronic wheezing (atopic with pneumonia 83.3%, n=5/6 vs atopic without pneumonia 21.4%, n=3/14), P=.018.ConclusionLow serum CC16 is associated with previously expressed pneumonia and chronic wheezing in atopic children.
Good's buffer ionic liquids as relevant phase‐forming components of self‐buffered aqueous biphasic systems
Authors: Taha Mohamed , Quental Maria V , e Silva Francisca A , Capela Emanuel V , Freire Mara G , Ventura Sónia PM , Coutinho João AP 
Published: February 2017

AbstractBACKGROUNDSelf‐buffered aqueous biphasic systems (ABS) are prepared with ionic liquids (ILs) based on Good's buffers (GB‐ILs) and used to purify proteins.RESULTSA set of new GB‐ILs based on the tetrabutylphosphonium cation ([P4444]+) was here synthesized and characterized. The self‐buffering behaviour of the GB‐ILs was asserted by measuring their protonation constants by potentiometry. These ionic liquids display self‐buffering characteristics as well as a low toxicity towards the luminescent bacteria Vibrio fischeri. The ability of the GB‐ILs to form ABS with the potassium citrate salt was investigated. These systems were then evaluated to extract and purify BSA from bovine serum samples. Extraction efficiencies of 100 ± 5% of BSA to the GB‐IL‐rich phase were obtained in a single step. In addition, good recovery yields (59.4 ± 0.8% to 80.1 ± 0.7%), and purity levels of BSA (75.0 ± 0.3% to 92 ± 1%) were also achieved. The BSA secondary structure in the aqueous IL‐rich solutions was evaluated through infrared spectroscopic studies revealing the protein‐friendly nature of the synthesized GB‐ILs. Dynamic light scattering (DLS), ‘Conductor‐like Screening Model for Real Solvents’ (COSMO‐RS), and molecular docking studies were carried out to better understand the main driving forces of the extraction process.CONCLUSIONThe results obtained show that GB‐IL based ABS can be prepared and used for protein purifications, with the GB‐ILs showing a stabilizing effect on the protein. © 2017 Society of Chemical Industry
Performance analysis of the ultra weak variational formulation to compute electromagnetic fields on nonuniform meshes
Authors: Gimpel Alfred , Silva Elson J. , Afonso Marcio M. 
Published: February 2017

AbstractThe purpose of this work is to apply a previously developed ultra weak variational formulation (UWVF) to the solution of the Helmholtz equation in electromagnetic scattering problems. The variational form is based on discontinuous Galerkin with plane wave basis functions in 2‐dimensional finite element mesh. We present a general strategy, which allows to adjust the number of wave directions based on both the element size and the local conditioning number. This provides a cost‐effective mechanism for application of UWVF using nonuniform meshes. Through simulation of scattering of a dielectric‐coated circular cylinder, it is shown that the process significantly improves the UWVF performance.
Simulation of liquefaction of unsaturated soil using critical state soil model
Authors: Komolvilas Veerayut , Kikumoto Mamoru 
Published: February 2017

SummarySeveral researchers have reported that the mean effective stress of unsaturated soils having a relatively high degree of saturation gradually decreases under fully undrained cyclic loading conditions, and such soils can be finally liquefied like saturated soils. This paper describes a series of simulations of fully undrained cyclic loading on unsaturated soils, conducted using an elastoplastic model for unsaturated soils. This model is a critical state soil model formulated using effective stress tensor for unsaturated soils, which incorporates the following concepts: (a) the volumetric movement of the state boundary surface containing the critical state line owing to the variation in the degree of saturation; (b) the soil water characteristic curve considering the effects of specific volume and hydraulic hysteresis; and (c) the subloading surface concept for considering the effect of density. Void air is assumed to be an ideal gas obeying Boyle's law. The proposed model is validated through comparisons with past results. The simulation results show that the proposed model properly describes the fully undrained cyclic behavior of unsaturated soils, such as liquefaction, compression, and an increase in the degree of saturation. Finally, the effects of the degree of saturation, void ratio, and confining pressure on the cyclic strength of unsaturated soils are described by the simulation results. The liquefaction resistance of unsaturated soils increases as the degree of saturation and the void ratio decrease, and as the confining pressure increases. Furthermore, the degree of saturation has a greater effect on the liquefaction resistance than the confining pressure and void ratio. Copyright © 2017 John Wiley & Sons, Ltd.