bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosing laser-induced damage to optical thin films using peak sound pressure of shock waves
Authors: Jinman G. , Junhong S. , Shenjiang W. , Junqi X. , Lei C. , Ning L. 
Published: March 2017

AbstractLaser-induced damage threshold (LIDT) is an important parameter used to describe the resistance of optical thin films to laser damage. The service life and cost of optical systems depend on the LIDT of the film. Thus, the precision with which the film's LIDT can be measured impacts how well the service life and cost of the system can be predicted. Therefore, it is important to find a precise approach to diagnose a film's laser-induced damage. In this paper, characteristics of the peak sound pressure of laser-induced plasma shock waves from thin films have been systematically investigated experimentally. We found that the peak sound pressure decays rapidly with propagation distance during air transmission. Based on a theoretical analysis of the relationship between the peak sound pressure and the laser damage to a film, we propose a method for diagnosing laser damage using the peak sound pressure of a thin film's shock wave. Our results show that this method can simplify implementation, which will provide a new method with which to diagnose laser damage to thin films.
Development of compact nanosecond pulsed X-ray source
Authors: Li M.J. , Chen D.Y. , Zhou L. , Liang C. , Zhou L. , You H.B. 
Published: March 2017

AbstractA compact nanosecond pulsed X-ray source is described. The X-ray source consists of two important subassemblies: a high-voltage pulse generator and an X-ray diode. The high-voltage pulse generator is designed based on the principle of triple resonance circuit producing a high-voltage pulse across the X-ray diode with amplitude of up to 500 kV. The X-ray diode is a sealed transmission target X-ray tube. Its cathode is comb structure formed from thin tungsten sheets with thickness 50 µm, while its target is made of 100 µm titanium film. The X-ray dose at a distance of 20 cm from the diode is 20 mR per pulse, while the diode voltage is 512 kV. In the case, the full-width at half-maximum of the X-ray pulse is ~5 ns.
Continuous population declines for specialist farmland birds 1987-2014 in Denmark indicates no halt in biodiversity loss in agricultural habitats
Authors: HELDBJERG HENNING , SUNDE PETER , FOX ANTHONY DAVID 
Published: March 2017

SummaryThe 2020 EU biodiversity strategy aims to halt the loss of biodiversity and ecosystem services, but this requires effective monitoring to determine whether these aims are achieved. Common bird monitoring continuously assesses changes in the avian community, providing a powerful tool for monitoring temporal changes in the abundance and distribution of these upper trophic level consumers. Two-thirds of Denmark’s land area is intensively farmed, so agricultural habitats make a major contribution to Danish biodiversity. We looked for changes in abundance amongst farmland birds in Denmark during 1987–2014 to test for reductions in declines and to predict whether the 2020-target can be expected to be achieved. Sixteen specialist farmland species were those showing the most rapid declines amongst 102 common breeding species in Denmark. Of these, those species nesting on the ground showed significant long-term declines, which was not the case for those that nest elsewhere, i.e. in hedgerows, trees and buildings. There was no evidence to suggest that these trends were attributable to widespread declines in long-distance migrant species (as reported elsewhere), which may be affected by conditions at other times in the annual cycle. We therefore conclude that continued declines in specialist farmland breeding bird species are due to contemporary agricultural changes within Denmark and urge habitat- and species-specific analysis to identify the core causes of these changes and halt the declines.
Extracorporeal membrane oxygenation support for hypertrophic cardiomyopathy in an infant of a diabetic mother
Authors: Udine Michelle L. , Romp Robb L. , Jackson Kimberly W. 
Published: March 2017

AbstractInfants of diabetic mothers are at risk for transient hypertrophic cardiomyopathy. These infants are typically asymptomatic, but may develop signs of poor cardiac output from left ventricular outflow tract obstruction. This case illustrates the successful use of extracorporeal membrane oxygenation to support cardiac output in an infant of a diabetic mother with outflow tract obstruction until hypertrophy improved.
Interconnection: A qualitative analysis of adjusting to living with renal cell carcinoma
Authors: Leal Isabel , Milbury Kathrin , Engebretson Joan , Matin Surena , Jonasch Eric , Tannir Nizar , Wood Christopher G. , Cohen Lorenzo 
Published: March 2017

ABSTRACTObjective:Adjusting to cancer is an ongoing process, yet few studies explore this adjustment from a qualitative perspective. The aim of our qualitative study was to understand how patients construct their experience of adjusting to living with cancer.Method:Qualitative analysis was conducted of written narratives collected from four separate writing sessions as part of a larger expressive writing clinical trial with renal cell carcinoma patients. Thematic analysis and constant comparison were employed to code the primary patterns in the data into themes until thematic saturation was reached at 37 participants. A social constructivist perspective informed data interpretation.Results:Interconnection described the overarching theme underlying the process of adjusting to cancer and involved four interrelated themes: (1) discontinuity—feelings of disconnection and loss following diagnosis; (2) reorientation—to the reality of cancer psychologically and physically; (3) rebuilding—struggling through existential distress to reconnect; and (4) expansion—finding meaning in interconnections with others. Participants related a dialectical movement in which disruption and loss catalyzed an ongoing process of finding meaning.Significance of results:Our findings suggest that adjusting to living with cancer is an ongoing, iterative, nonlinear process. The dynamic interactions between the different themes in this process describe the transformation of meaning as participants move through and revisit prior themes in response to fluctuating symptoms and medical news. It is important that clinicians recognize the dynamic and ongoing process of adjusting to cancer to support patients in addressing their unmet psychosocial needs throughout the changing illness trajectory.
Minimal residual disease in melanoma: circulating melanoma cells and predictive role of MCAM/MUC18/MelCAM/CD146
Authors: Rapanotti Maria Cristina , Campione Elena , Spallone Giulia , Orlandi Augusto , Bernardini Sergio , Bianchi Luca 
Published: March 2017

AbstractCirculating tumour cells (CTCs), identified in numerous cancers including melanoma, are unquestionably considered valuable and useful as diagnostic and prognostic markers. They can be detected at all melanoma stages and may persist long after treatment. A crucial step in metastatic processes is the intravascular invasion of neoplastic cells as circulating melanoma cells (CMCs). Only a small percentage of these released cells are efficient and capable of colonizing with a strong metastatic potential. CMCs' ability to survive in circulation express a variety of genes with continuous changes of signal pathways and proteins to escape immune surveillance. This makes it difficult to detect them; therefore, specific isolation, enrichment and characterization of CMC population could be useful to monitor disease status and patient clinical outcome. Overall and disease-free survival have been correlated with the presence of CMCs. Specific melanoma antigens, in particular MCAM (MUC18/MelCAM/CD146), could be a potentially useful tool to isolate CMCs as well as be a prognostic, predictive biomarker. These are the areas reviewed in the article.
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Authors: Sonoiki Ebere , Ng Caroline L. , Lee Marcus C. S. , Guo Denghui , Zhang Yong-Kang , Zhou Yasheen , Alley M. R. K. , Ahyong Vida , Sanz Laura M. , Lafuente-Monasterio Maria Jose , Dong Chen , Schupp Patrick G. , Gut Jiri , Legac Jenny , Cooper Roland A. , Gamo Francisco-Javier , DeRisi Joseph , Freund Yvonne R. , Fidock David A. , Rosenthal Philip J. 
Published: March 2017

AbstractBenzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolates (mean ex vivo IC50 64 nM), and murine P. berghei and P. falciparum infections (day 4 ED90 0.34 and 0.57 mg kg−1, respectively). Multiple P. falciparum lines selected in vitro for resistance to AN3661 harboured point mutations in pfcpsf3, which encodes a homologue of mammalian cleavage and polyadenylation specificity factor subunit 3 (CPSF-73 or CPSF3). CRISPR-Cas9-mediated introduction of pfcpsf3 mutations into parental lines recapitulated AN3661 resistance. PfCPSF3 homology models placed these mutations in the active site, where AN3661 is predicted to bind. Transcripts for three trophozoite-expressed genes were lost in AN3661-treated trophozoites, which was not observed in parasites selected or engineered for AN3661 resistance. Our results identify the pre-mRNA processing factor PfCPSF3 as a promising antimalarial drug target.
The missing Northern European winter cooling response to Arctic sea ice loss
Authors: Screen James A. 
Published: March 2017

AbstractReductions in Arctic sea ice may promote the negative phase of the North Atlantic Oscillation (NAO−). It has been argued that NAO-related variability can be used an as analogue to predict the effects of Arctic sea ice loss on mid-latitude weather. As NAO− events are associated with colder winters over Northern Europe, a negatively shifted NAO has been proposed as a dynamical pathway for Arctic sea ice loss to cause Northern European cooling. This study uses large-ensemble atmospheric simulations with prescribed ocean surface conditions to examine how seasonal-scale NAO− events are affected by Arctic sea ice loss. Despite an intensification of NAO− events, reflected by more prevalent easterly flow, sea ice loss does not lead to Northern European winter cooling and daily cold extremes actually decrease. The dynamical cooling from the changed NAO is ‘missing’, because it is offset (or exceeded) by a thermodynamical effect owing to advection of warmer air masses.
Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
Authors: Tang Patrick Ming-Kuen , Zhou Shuang , Meng Xiao-Ming , Wang Qing-Ming , Li Chun-Jie , Lian Guang-Yu , Huang Xiao-Ru , Tang Yong-Jiang , Guan Xin-Yuan , Yan Bryan Ping-Yen , To Ka-Fai , Lan Hui-Yao 
Published: March 2017

AbstractTGF-β is known to influence tumour progression. Here we report an additional role of Smad3 in the tumour microenvironment regulating cancer progression. Deletion or inhibition of Smad3 in the tumour microenvironment suppresses tumour growth, invasion and metastasis in two syngeneic mouse tumour models. Smad3−/−bone marrow gives rise to an expanded NK cell population with enhanced tumour-suppressive activitiesin vivo, and promotes differentiation of NK cellsex vivo. We identify E4BP4/NFIL3 as a direct Smad3 target gene critical for NK cell differentiation. Smad3 suppresses transcription of IFN-γ via E4BP4 in a T-bet independent manner. Therefore disruption of Smad3 enhances both the E4BP4-mediated NK cell differentiation and anti-cancer effector functionsin vivoandin vitro. Furthermore, systemic treatment with a Smad3 inhibitor SIS3 effectively suppresses cancer progression. In summary, suppression of NK cell-mediated immunosurveillance via the Smad3-E4BP4 axis contributes to cancer progression. We propose targeting Smad3-dependent tumour microenvironment may represent an effective anti-cancer strategy.
T cell costimulation blockade blunts pressure overload-induced heart failure
Authors: Kallikourdis Marinos , Martini Elisa , Carullo Pierluigi , Sardi Claudia , Roselli Giuliana , Greco Carolina M. , Vignali Debora , Riva Federica , Ormbostad Berre Anne Marie , Stølen Tomas O. , Fumero Andrea , Faggian Giuseppe , Di Pasquale Elisa , Elia Leonardo , Rumio Cristiano , Catalucci Daniele , Papait Roberto , Condorelli Gianluigi 
Published: March 2017

AbstractHeart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. Searching for better cardiac inflammation targets, here we link T cells with HF development in a mouse model of pathological cardiac hypertrophy and in human HF patients. T cell costimulation blockade, through FDA-approved rheumatoid arthritis drug abatacept, leads to highly significant delay in progression and decreased severity of cardiac dysfunction in the mouse HF model. The therapeutic effect occurs via inhibition of activation and cardiac infiltration of T cells and macrophages, leading to reduced cardiomyocyte death. Abatacept treatment also induces production of anti-inflammatory cytokine interleukin-10 (IL-10). IL-10-deficient mice are refractive to treatment, while protection could be rescued by transfer of IL-10-sufficient B cells. These results suggest that T cell costimulation blockade might be therapeutically exploited to treat HF.
The role of quantum measurement in stochastic thermodynamics
Authors: Elouard Cyril , Herrera-Martí David A. , Clusel Maxime , Auffèves Alexia 
Published: March 2017

AbstractThis article sets up a new formalism to investigate stochastic thermodynamics in the quantum regime, where stochasticity and irreversibility primarily come from quantum measurement. In the absence of any bath, we define a purely quantum component to heat exchange, that corresponds to energy fluctuations caused by quantum measurement. Energetic and entropic signatures of measurement-induced irreversibility are then explored for canonical experiments of quantum optics, and the energetic cost of counter-acting decoherence is studied on a simple state-stabilizing protocol. By placing quantum measurement in a central position, our formalism contributes to bridge a gap between experimental quantum optics and quantum thermodynamics, and opens new paths to characterize the energetic features of quantum processing.
Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
Authors: Ross Robert J. H. , Baker R. E. , Parker Andrew , Ford M. J. , Mort R. L. , Yates C. A. 
Published: March 2017

AbstractIn this work, we implement approximate Bayesian computational methods to improve the design of a wound-healing assay used to quantify cell–cell interactions. This is important as cell–cell interactions, such as adhesion and repulsion, have been shown to play a role in cell migration. Initially, we demonstrate with a model of an unrealistic experiment that we are able to identify model parameters that describe agent motility and adhesion, given we choose appropriate summary statistics for our model data. Following this, we replace our model of an unrealistic experiment with a model representative of a practically realisable experiment. We demonstrate that, given the current (and commonly used) experimental set-up, our model parameters cannot be accurately identified using approximate Bayesian computation methods. We compare new experimental designs through simulation, and show more accurate identification of model parameters is possible by expanding the size of the domain upon which the experiment is performed, as opposed to increasing the number of experimental replicates. The results presented in this work, therefore, describe time and cost-saving alterations for a commonly performed experiment for identifying cell motility parameters. Moreover, this work will be of interest to those concerned with performing experiments that allow for the accurate identification of parameters governing cell migratory processes, especially cell migratory processes in which cell–cell adhesion or repulsion are known to play a significant role.
Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1
Authors: Subramanian Madhan , MohanKumar Sheba M. J. , Balasubramanian Priya , Northcott Carrie A. , Garver Hannah , Fink Gregory D. , MohanKumar P. S. 
Published: March 2017

AbstractPreviously, we demonstrated that chronic exposure to low levels of estradiol-17β (E2) increases mean arterial pressure (MAP) in young female Sprague-Dawley (SD) rats, however, the underlying mechanisms are unclear. Since endothelin-1 (ET-1) is implicated in blood pressure (BP) regulation, we hypothesized that E2’s effects on MAP are mediated through central ET-1. To test this, young female SD rats were either sham implanted or implanted s.c. with slow-release E2 pellets (20 ng/day for 90 days). BP was monitored by telemetry. After 75 days of E2 exposure, ETA antagonist or vehicle was administered i.c.v. After 90 days of E2 exposure, rats were sacrificed, and the paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM) were microdissected for gene expression and protein analysis of ET-1 and its receptors. E2 exposure increased MAP after pellet implantation. Gene expression of ET-1 and ETA but not ETB receptors were upregulated in the PVN and RVLM of E2 treated animals. Further, the protein levels of ETA receptor were also increased in the PVN of E2 treated animals. However, i.c.v. infusion of the ETA antagonist did not completely block the increase in blood pressure. Our results suggest that increases in central ET-1 activity could possibly play a role in chronic E2-induced increase in BP but further studies are needed to completely understand the contribution of ET-1 in this phenomenon.
Vein networks in hydrothermal systems provide constraints for the monitoring of active volcanoes
Authors: Cucci Luigi , Di Luccio Francesca , Esposito Alessandra , Ventura Guido 
Published: March 2017

AbstractVein networks affect the hydrothermal systems of many volcanoes, and variations in their arrangement may precede hydrothermal and volcanic eruptions. However, the long-term evolution of vein networks is often unknown because data are lacking. We analyze two gypsum-filled vein networks affecting the hydrothermal field of the active Lipari volcanic Island (Italy) to reconstruct the dynamics of the hydrothermal processes. The older network (E1) consists of sub-vertical, N-S striking veins; the younger network (E2) consists of veins without a preferred strike and dip. E2 veins have larger aperture/length, fracture density, dilatancy, and finite extension than E1. The fluid overpressure of E2 is larger than that of E1 veins, whereas the hydraulic conductance is lower. The larger number of fracture intersections in E2 slows down the fluid movement, and favors fluid interference effects and pressurization. Depths of the E1 and E2 hydrothermal sources are 0.8 km and 4.6 km, respectively. The decrease in the fluid flux, depth of the hydrothermal source, and the pressurization increase in E2 are likely associated to a magma reservoir. The decrease of fluid discharge in hydrothermal fields may reflect pressurization at depth potentially preceding hydrothermal explosions. This has significant implications for the long-term monitoring strategy of volcanoes.
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways
Authors: García Marta , Barrio Raquel , García-Lavandeira Montserrat , Garcia-Rendueles Angela R. , Escudero Adela , Díaz-Rodríguez Esther , Gorbenko Del Blanco Darya , Fernández Ana , de Rijke Yolanda B. , Vallespín Elena , Nevado Julián , Lapunzina Pablo , Matre Vilborg , Hinkle Patricia M. , Hokken-Koelega Anita C. S. , de Miguel María P. , Cameselle-Teijeiro José Manuel , Nistal Manuel , Alvarez Clara V. , Moreno José C. 
Published: March 2017

AbstractIGSF1 (Immunoglobulin Superfamily 1) gene defects cause central hypothyroidism and macroorchidism. However, the pathogenic mechanisms of the disease remain unclear. Based on a patient with a full deletion of IGSF1 clinically followed from neonate to adulthood, we investigated a common pituitary origin for hypothyroidism and macroorchidism, and the role of IGSF1 as regulator of pituitary hormone secretion. The patient showed congenital central hypothyroidism with reduced TSH biopotency, over-secretion of FSH at neonatal minipuberty and macroorchidism from 3 years of age. His markedly elevated inhibin B was unable to inhibit FSH secretion, indicating a status of pituitary inhibin B resistance. We show here that IGSF1 is expressed both in thyrotropes and gonadotropes of the pituitary and in Leydig and germ cells in the testes, but at very low levels in Sertoli cells. Furthermore, IGSF1 stimulates transcription of the thyrotropin-releasing hormone receptor (TRHR) by negative modulation of the TGFβ1-Smad signaling pathway, and enhances the synthesis and biopotency of TSH, the hormone secreted by thyrotropes. By contrast, IGSF1 strongly down-regulates the activin-Smad pathway, leading to reduced expression of FSHB, the hormone secreted by gonadotropes. In conclusion, two relevant molecular mechanisms linked to central hypothyroidism and macroorchidism in IGSF1 deficiency are identified, revealing IGSF1 as an important regulator of TGFβ/Activin pathways in the pituitary.
MiR-139-5p as a novel serum biomarker for recurrence and metastasis in colorectal cancer
Authors: Miyoshi Jinsei , Toden Shusuke , Yoshida Kazuhiro , Toiyama Yuji , Alberts Steven R. , Kusunoki Masato , Sinicrope Frank A. , Goel Ajay 
Published: March 2017

AbstractApproximately 30–50% of colorectal cancer (CRC) patients who undergo curative resection subsequently experience tumor recurrence or metastasis. Although microRNAs (miRNAs) are a class of small noncoding RNAs frequently deregulated in various human malignancies, it remains unknown if these can help predict recurrence and metastasis in CRC patients. MiRNAs were initially screened using miRNA-microarray and miRNA-seq datasets with or without recurrence. Candidate miRNAs were then tested in two independent cohorts of 111 stage II/III and 139 stage I-III CRC patients, as well as serum samples and matched primary and metastatic liver tissues. An animal model of peritoneal dissemination was used to assess the oncogenic role of the target miRNA. Four candidate miRNAs were identified during the initial screening, and we subsequently validated upregulation of miR-139-5p in two independent clinical cohorts, wherein it associated with poor recurrence-free survival. Moreover, miR-139-5p were also upregulated in the serum of recurrence-positive CRC patients and yielded significantly shorter recurrence-free survival. Intriguingly, miR-139-5p was upregulated in metastatic liver tissues and negatively correlated with genes associated with epithelial-mesenchymal transition. Lastly, we showed that miR-139-5p overexpression enhanced peritoneal dissemination in a mouse model. In conclusion, we identified miR-139-5p as a novel biomarker for tumor recurrence and metastasis in CRC.