bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Observational Study of Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer and Colorectal Cancer From a Single Center in the Recent 5 years
Authors: He Miao , Li Xiao-dong , Wang Zi-wei , Sun Hao , Fan Jing 
Published: September 2024

Objective To retrospectively analyze the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) on the progression free survival (PFS) of advanced gastric cancer (GC) and colorectal cancer (CRC). Method We retrospectively collected all the HIPEC data of GC and CRC in the Chongqing University Cancer Hospital from August 2018 to April 2023. Data were extracted from inpatient records and outpatient examination records. The IBM SPSS statistics 23.0 software was used to analyze the data. We mainly compared the PFS of HIPEC cases with that of non-HIPEC cases (both from our center and from the literature). PFS was analyzed with the Kaplan-Meier method. Log Rank (Mantel Cox), Breslow (Generalized Wilcoxon), and Tarone-Ware were used for univariate analyses. Result A total of 342 HIPEC cases were analyzed in this study. Stage IV GC and CRC accounted for 48.5% of the total number of cases. Abdominal pain and distension (47.4%) were the most common side effects from HIPEC. Serious complications were rare (1.8%, including bleeding, perforation, obstruction, and death). The PFS and disease-free survival (DFS) of abdominal malignancy treated with HIPEC were significantly associated with the TNM stage, but not HIPEC numbers nor HIPEC drugs. In stage IV HIPEC cases, adding adjuvant chemotherapy after HIPEC resulted in better PFS. In addition, the association between peritoneal carcinomatosis index (PCI) and PFS of stage IV HIPEC cases was close to significant. Compared with the 33 stage IV (with peritoneal metastases) GC cases without HIPEC in our center from the last 15 years, the PFS of the 56 stage Ⅳ GC cases with HIPEC was not improved significantly (median PFS: 6 ± 2.92 months vs 7 ± 1.63 months for with vs without HIPEC in stage IV GC, respectively; P ≥ 0.05). Compared with the 58 stage IV (with peritoneal metastases) CRC cases without HIPEC in our center from the last 15 years, the PFS of the 86 stage IV CRC cases with HIPEC was not improved significantly either (median PFS: 7 ± 1.68 months vs 7 ± 0.62 months for with vs without HIPEC in stage IV CRC, respectively; P ≥ 0.05). When comparing our HIPEC data with the non-HIPEC data reported by other scholars for the PFS of advanced GC and CRC, the negative results were similar. Conclusion The PFS/DFS of HIPEC cases was associated with the TNM stage, but not with the HIPEC numbers or HIPEC drugs. PCI may be related to the PFS of stage IV HIPEC cases. Adding chemotherapy or targeted therapy after HIPEC may improve the PFS of stage IV cases. HIPEC did not significantly improve the PFS of stage IV GC or CRC cases in our center.
Benign Lobular Inner Nuclear Layer Proliferations of the retina
Authors: Córdoba-Ortega Carlos M , Arias Aristizabal Juan D , Gómez Velasco Maira Alexandra , Martinez Pulgarín Dayron F 
Published: September 2024

Purpose Report the clinical and imaging findings of a patient with an intraretinal benign tumor that was documented as an unexpected clinical finding after an ischemic stroke in the context of mitral valve disease. This tumor must be distinguished from retinoblastoma and other malignant neoplasms. Methods A patient with intraretinal tumor of the inner nuclear layer (INL) underwent a combination of ophthalmic examination, fundus photography, fluorescein angiography, optical coherence tomography (OCT), and optical coherence tomography angiography (OCT-A) Results A 64-year-old male patient with unilateral benign tumor lesions dependent on the internal retina, centered in the posterior pole, and multifocal. OCT showed that these lesions were centered within the INL at the edge of the inner plexiform layer and were not associated with other findings in the posterior pole. Conclusions Benign Lobular Inner Nuclear Layer Proliferations (BLIP) of the Retina are recently described lesions that should be considered, given their distinctive characteristics that set them apart from other benign and malignant retinal lesions.
Short report: Prison-reported rates of autism in female prisons in England
Authors: Payne Katy-Louise , Gooding Emma 
Published: September 2024

Research suggests that whilst not more likely to offend, autistic people are overrepresented within the Criminal Justice System. To date, prevalence estimates are available only for male autistic offenders. Thus, this research aimed to provide the prison-reported rate of autistic female prisoners currently residing in the female prison estate in England. All 12 of the female prisons in England were contacted to request the following information: (1) the total number of autistic females; and (2) the total female prison population. Findings show an English female prison-reported rate of autism of 4.78% indicating that autism is approximately 13.7 times higher in female prisons compared to the general population. To the authors’ knowledge, this is the first research article to focus exclusively on female autistic offenders. Further research is needed to understand the risk factors for offending, offender characteristics, offence types/patterns and autistic experience of the Criminal Justice System for female autistic offenders. Lay abstract What is already known about the topic? Autistic people are reported to offend at lower or comparable rates to non-autistic people. However, autism is overrepresented within male prisons due to a number of suggested reasons including an increased chance of being caught and a lack of autistic sensitive interventions which lead to longer stays in prison. To the authors’ knowledge, no papers currently exist focussing on autistic females in prison. What does this paper add? To the authors’ knowledge, this is the first piece of research to solely include autistic females in prison settings. This research provides an estimate of how many autistic people are in female prisons. All 12 female prisons in England were contacted. Data provided indicate a prison-reported female autism rate of 4.78%. This prison-reported female autism rate is 13.7 times higher than the prevalence of autistic females in the general population. Implications for practice research or policy? Autism is overrepresented in female prisons; however, to the authors’ knowledge no current research exists on this group to understand their needs or experience. Autistic females often have differing requirements to males and the lack of research highlights the need for future research to investigate areas such as factors which increase the risk of offending, offences typically committed and the female autistic experience of the Criminal Justice System.
Seen and Heard: Combining In-Depth Interviewing With Social Messaging to Study the Lived Experiences of Gifted Youth in High Power Distance Cultures
Authors: Wan Mohd Nor Sofiya , Krauss Steven , Roslan Samsilah , Syed-Abdullah Sharifah Intan Sharina 
Published: September 2024

Qualitative research with gifted youth presents unique challenges because of their tendency to display qualities such as perfectionism, overexcitability, and asynchronous development. Studying gifted youth in cultural contexts marked by high power distance between young people and adults can further compound these challenges by limiting gifted youths’ feelings of psychological safety during data collection. As a result, gifted youth often withhold information or give perceived culturally appropriate answers to adult researchers’ queries. Drawing on a larger phenomenological study of the formation of self-concept among eight Malaysian gifted youth aged between 18 and 25 years old, this article describes how an innovative application of combining semi-structured interviews with WhatsApp social messaging diaries helped minimize the power imbalance between the researcher and youth participants. The paper describes the unique methodological strategy of combining in-depth phenomenological interviews with WhatsApp diary entries to collect data from a hard-to-reach population. Specific techniques employed included using a conversational interview style, self-disclosing personal information to build trust, and validating participants’ feelings and experiences are discussed. Open-ended WhatsApp diary prompts and an extended time provided a sense of anonymity which allowed participants to recall their past and discuss sensitive experiences. Combining these techniques facilitated in-depth exploration into the lived experiences and challenges of being gifted, and how giftedness shaped participants’ self-concept. This is the first known study to document the use of social messaging applications as an effective journaling method for creating a familiar and safe space for special needs groups in high power distance cultures to share their experiences and feelings.
The enhanced recovery after surgery protocol in paediatric surgery: The analysis of the protocol principles based on a survey among Polish clinical centres
Authors: Pasierbek Michal Jerzy , Modrzyk Anna , Korlacki Wojciech 
Published: September 2024

Introduction: The enhanced recovery after surgery (ERAS) protocol is a complex set of measures that improves patient outcomes in the adult population. The main goal of the protocol is to sustain homeostasis by mitigating the metabolic stress induced by surgical procedures. Hence, the search for similar solutions in paediatric patients since the benefits in the paediatric population are less well known. Material and methods: The principles of the ERAS protocol were presented. A questionnaire survey was prepared to assess the preparation for the implementation of ERAS in paediatric surgery departments. Heads of all 19 clinical centres from Poland providing colorectal surgery in children were invited to participate. Seven centres responded to the survey. The questionnaire included four general questions related to the familiarity with ERAS and specific questions about the implementation of the 23-item protocol. Results: Five centres confirmed familiarity with the principles of the protocol and two of them confirmed the use of ERAS. The lowest number of implemented procedures was six, while the highest number was 18 out of 23. No centre implemented the zero fluid balance strategy. However, as many as five of the seven centres avoided preoperative fasting, three centres avoided mechanical bowel preparation, and three respondents used early oral nutrition in the postoperative period. Conclusions: The ERAS protocol is commonly used and accepted worldwide. Other surgical teams may use the information contained in the manuscript to create or improve their ERAS protocol.
Efficacy of carboplatin–etoposide rechallenge after first-line chemo-immunotherapy in ES-SCLC: an international multicentric analysis
Authors: Gomez-Randulfe Igor , Silva Díaz Sofía , Escriu Carles , Mohammed Saara , Shah Riyaz , Benitez Fuentes Javier David , Cox Samantha , Monaca Federico , Bria Emilio , García-Campelo María Rosario , Crook Benjamin , Talbot Toby , Leporati Rita , Balachandran Kirsty , Newsom-Davis Tom , Hughes Sarah , Cove-Smith Laura , Taylor Paul , Blackhall Fiona , Califano Raffaele 
Published: September 2024

Background and objectives: Second-line treatment for small-cell lung cancer (SCLC) is primarily guided by the time elapsed since the last platinum dose. Rechallenge with carboplatin and etoposide has demonstrated superior outcomes compared to topotecan if the platinum-free interval (PFI) is longer than 90 days and is considered the standard of care. However, these findings predate the chemo-immunotherapy era. This study investigates the effectiveness of the rechallenge strategy after chemo-immunotherapy in a real-world setting. Design and methods: We retrospectively reviewed patients with the extensive stage (ES)-SCLC who received rechallenge with carboplatin and etoposide after first-line chemoimmunotherapy between September 2020 and August 2023 in nine European centres. Demographic and clinical data were collected and analysed. Results: A total of 93 patients were included. Sixty-six (71%) patients had a PFI between 3 and 6 months. Consolidation thoracic radiotherapy and prophylactic cranial irradiation had been administered in 31 (33.3%) patients and 20 (21.5%) patients, respectively. Overall response rate was 59.1%. Median progression-free survival (PFS) was 5 months (95% confidence interval (CI) 4.3–5.7) and median overall survival (OS) was 7 months (95% CI 5.7–8.3). Notably, PFS and OS were not different according to PFI (3–6 m vs > 6 m). Conclusion: Rechallenge with carboplatin and etoposide is a valid second-line option in patients with ES-SCLC whose disease progresses after first-line chemoimmunotherapy. Our analysis shows similar results to previous studies. Furthermore, outcomes were consistent across patients with different PFIs, confirming its efficacy in patients with a PFI longer than 3 months.
Successful use of a 3D-printed surgical guide to facilitate transiliosacral fixation in a cat with bilateral sacroiliac luxation
Authors: Scortea Radu , Reichardt Fee , Muresan Cosmin , Krauß Maximiljan 
Published: September 2024

Case summary A 7-year-old male castrated domestic shorthair cat was presented for treatment of a bilateral sacroiliac luxation (SIL). CT was performed and the data were extracted in a stereolithography (STL) file, after which a 3D-printed drill guide (3DPDG) was devised, using computer-aided design (CAD) software, and printed. Using an open surgical approach, the guide was used as an aid for drilling the sacrum. The ilial wings were drilled free-hand later and a transiliosacral pin (TP) was inserted to realign and stabilise the SIL. The cat exhibited an early return to normal limb function and a CT scan performed at the postoperative follow-up showed early signs of bone remodelling at the sacroiliac joint. Relevance and novel information To the authors’ knowledge, this is the first report using a 3DPDG for implant placement in the feline sacrum without intraoperative imaging.
ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch
Authors: Jiang Liqing , Lu Linhe , Xue Chao , Sun He , Ren Kai , Zhang Liyun , Zhu Hanzhao , Zhang Bin , Wang Xiaoya , Qiao Xinan , Peng Xiangyan , Liu Jincheng , Duan Weixun 
Published: September 2024

Abstract
Background
Thoracic aortic dissection (TAD) is an irreversible cardiovascular disorder with high mortality and morbidity. However, the molecular mechanisms remain elusive. Thus, identifying an effective therapeutic target to prevent TAD is especially critical. The purpose of this study is to elucidate the potential mechanism of inflammation and vascular smooth muscle cell (VSMCs) phenotypic switch in β-aminopropionitrile fumarate (BAPN)-induced TAD.

Methods
A mouse model of TAD induced by BAPN and IL-1β -stimulated HVSMCs in vivo and in vitro models, respectively. ACE2 Knockdown mice treated with BAPN or without, and the TAD mouse model was treated with or without AAV-ACE2. Transthoracic ultrasound was conducted for assessment the maximum internal diameter of the thoracic aorta arch. RNA sequencing analysis was performed to recapitulate transcriptome profile changes. Western blot were used to detect the expression of MMP2, MMP9, ACE2, SIRT3, OPN, SM22α and other inflammatory markers. The circulating levels of ACE2 was measured by ELISA assay. Histological changes of thoracic aorta tissues were assessed by H&E, EVG and IHC analysis.

Results
We found that circulating levels of and the protein levels of ACE2 were increased in the TAD mouse model and in patients with TAD. For further evidence, ACE2 deficiency decelerated the formation of TAD. However, overexpression of ACE2 aggravated BAPN-induced aortic injury and VSMCs phenotypic switch via lowered SIRT3 expression and elevated inflammatory cytokine expression.

Conclusion
ACE2 deficiency prevented the development of TAD by inhibiting inflammation and VSMCs phenotypic switch in a SIRT3-dependent manner, suggesting that the ACE2/SIRT3 signaling pathway played a pivotal role in the pathological process of TAD and might be a potential therapeutical target.
Vitality at home: a phenomenological study of tele-exercise in women aged 80 and older
Authors: Lee Janet Lok Chun , Chan Karly Oi Wan , Kwan Rick Yiu Cho , Wong Arnold Yu Lok 
Published: September 2024

Abstract
Background
Since the onset of coronavirus 2019, there has been an upsurge of tele-exercise delivery. Previous studies showed old adults find tele-exercise feasible and acceptable. However, there is limited understanding of the oldest-old’s experiences.

Method
This study used the interpretative phenomenological approach. Two semi-structured interviews and home visits were conducted with six oldest-old women, aged between 81 and 91 years, who participated in tele-exercise classes.

Results
Four superordinate themes were identified: ambivalent perception of safety, ease in regular participation, reminded and guided to move the aged body, and technological adaptation.

Conclusion
Our findings indicate that tele-exercise has the potential to assist the oldest-old living in the community in maintaining an adequate activity levels at home, which they perceive as the safest place. Emerging themes provide insights into their lived experiences, enabling service providers to enhance tele-exercise services for this group in the tele-health era.
Outcome of perioperative immune enhancing nutrition in patients undergoing radical cystectomy
Authors: Sultan Sultan Mohamed , Salman Baher , Abdelrazek Eman , Alorabi Ammar , Selim Mohamed 
Published: September 2024

Abstract
Background
Since radical cystectomy is associated with relatively high perioperative morbidity and mortality, this study was conducted to evaluate the efficacy of perioperative immune nutrition in radical cystectomy patients on postoperative outcomes including wound healing, postoperative complications, either infectious or non-infectious, and length of hospital stay.

Patients and methods
This prospective, randomized controlled study was conducted between June 2022 and November 2023. Forty-two patients who had undergone radical cystectomy with ileal conduit were randomized into two groups: the immune nutrition group, which received perioperative immune nutrition, and the conventional group, which did not receive immune nutrition. Patients were followed up for 30 days postoperatively to assess wound healing, infectious and non-infectious complications, and the length of hospital stay.

Results
Patients who received immune nutrition had significantly lower postoperative infectious complications (19.0 vs 61.9%; P = 0.004), shorter hospital stay (16.57 ± 3.74 vs 20.38 ± 5.97; P = 0.01) and shorter ICU stay (2.60 ± 1.07 vs 7.09 ± 7.50; P = 0.029). The proper wound healing was significantly higher in the immune nutrition group (90.5 vs 52.4%; P = 0.006). However, there was no significant difference between both groups in the rate of non-infectious complications (28.5% vs. 57.1%, P = 0.061).

Conclusion
Perioperative immune nutrition is associated with improved wound healing, reduced infectious complications, and reduced length of hospital stay.
Trial registration clinicaltrials.gov, NCT05822518. Registered 1 April 2023—Retrospectively registered, https://clinicaltrials.gov/study/NCT05822518.
Dioxin-like and estrogenic activity screening in fractionated sediments from a German catchment after the 2021 extreme flood
Authors: Johann Sarah , Düster Moritz , Bellanova Piero , Schwarzbauer Jan , Weber Alexandra , Wolf Stefanie , Schüttrumpf Holger , Lehmkuhl Frank , Hollert Henner 
Published: September 2024

Abstract
Background
The flood in July 2021 is considered one of the largest flood disasters in Western Europe in decades, with massive socio-economic consequences. The potential emission and remobilization of anthropogenic pollutants can lead to additional environmental consequences, which need to be addressed in long-term mitigation strategies. The Inde River and its tributary, the Vichtbach River, form a catchment located at the transition from the low mountain ranges of the Eifel to the lowlands of the Lower Rhine Embayment in Germany. The area has been an industrial and mining hotspot for centuries, making it a high-risk area for flood sediment pollution. The present study provides an ecotoxicological screening of flood sediments of the Vicht–Inde catchment to gain an impression of the degree of contamination by organic pollutants by means of in vitro effect-based method. Sediment samples were collected within days after the flood and fractionated prior to biotesting, and supportive instrumental geochemical analysis was performed.

Results
Flood sediments did not reveal estrogenic potential, which was included in the testing strategy as a relevant endpoint for industrial chemicals and untreated wastewater. In contrast, moderate-to-high dioxin-like activity was observed in 70% of the sediment samples with a peak dioxin-like potential at the restored section of the Inde. Overall, four hotspot samples were identified as at risk, which aligned mostly with the high concentration of organic pollutants including PAHs and PCBs. The fractionation allowed the identification of PAHs and their derivates as the most likely toxicity drivers for dioxin-like activity in the sediments of the Vicht–Inde catchment.

Conclusion
The results provide first information on the prioritization of hotspot locations at risk for a detailed ecotoxicological profiling and a post-flood monitoring of organic contamination. The identified sinks of contamination in the floodplain areas can be considered a source for remobilization of pollution in future flood events, which is highly relevant for the receiving Rur River.