bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital kiosks and inclusivity: a novel perspective on mobility hubs
Authors: Martinez Lluis , Garritsen Kelt , Baguet Jelten , Grigolon Anna , Münzel Karla , Keserü Imre , Geurs Karst 
Published: September 2024

AbstractMobility hubs facilitate multimodal transport and have the potential to improve the accessibility and usability of new mobility services. However, in the context of increasing digitalisation, using mobility hubs requires digital literacy or even owning a smartphone. This constraint may result in the exclusion of current and potential users. Digital kiosks might prove to be a solution, as they can facilitate the use of the services found at mobility hubs. Nevertheless, knowledge of how digital kiosks may improve the experience of disadvantaged groups remains limited in the literature. As part of the SmartHubs project, a field test with a digital kiosk was conducted with 105 participants in Brussels (Belgium) and Rotterdam (The Netherlands) to investigate the intention to use it and its usability in the context of mobility hubs. This study adopted a mixed methods approach, combining participant observation and questionnaire surveys. Firstly, participants were asked to accomplish seven tasks with the digital kiosk while being observed by the researchers. Finally, assisted questionnaire surveys were conducted with the same participants, including close-ended, open-ended and socio-demographic questions. The results offer insights into the experience of the users of a digital kiosk in a mobility hub and the differences across specific social groups. These findings may be relevant for decision-makers and practitioners working in urban mobility on subjects such as mobility hubs and shared mobility, and for user interface developers concerned with the inclusivity of digital kiosks.
Comparative immunohistochemical expression of Beta catenin and CD163 between dysplastic / non-dysplastic oral lichen planus and lichenoid lesions (EX-VIVO STUDY)
Authors: Saleh Heba Ahmed , Nabil Ghada , Badawy Sarah Ahmed Mohammed Mahmoud 
Published: September 2024

Abstract
Background
Oral lichen planus is a well-known chronic inflammatory mucocutaneous disorder, which has clinical and histological presentation that mimics oral lichenoid reaction. According to the fifth edition of WHO, both conditions are considered as oral potentially malignant disorders. Recent studies on oral potential disorders documented deregulation of some signaling molecules related to the Wnt/β-catenin pathway. Therefore this study aimed to compare the immune expression of β-catenin & CD163 in dysplastic /non-dysplastic cases of Oral lichen planus & oral lichenoid lesion. In addition, a statistical correlation between both immune markers was done regardless of the type of the study group.

Methods
Four study groups were designated as 2 groups of Oral lichen planus (one dysplastic & one non –dysplastic) and the other 2 groups were oral lichenoid lesions (one dysplastic & one non –dysplastic). Ten cases in each group were collected and investigated by immunohistochemistry. The area percent of beta catenin and also counting of m2 macrophages expressing + CD163 marker was calculated in the study groups.

Results
The Statistical analysis highlighted a statistically significant difference between the studied groups. Moreover, Pearson correlation test reported a significant moderate positive correlation between beta catenin & CD163 expression in the studied cases.

Conclusion
Our findings supported new perceptions of the mechanism by which tumor associated macrophage specific β-catenin signaling promotes the aggressive behavior of oral potential malignant disorders.

Clinical relevance
Evidence of the relationship between beta catenin and M2 macrophages (+ CD163) may enhance the development of macrophage-based strategies for treatment and improve the prognosis of such cases.
A SRC-slug-TGFβ2 signaling axis drives poor outcomes in triple-negative breast cancers
Authors: Angel Charlotte Zoe , Beattie Shannon , Hanif Ezanee Azlina Mohamad , Ryan Micheal P. , Guerra Liberal Francisco D. C. , Zhang Shu-Dong , Monteith Scott , Buckley Niamh E. , Parker Emma , Haynes Shannon , McIntyre Alexander J. , Haddock Paula , Sharifova Madina , Branco Cristina M. , Mullan Paul B. 
Published: September 2024

Abstract
Background
Treatment options for the Triple-Negative Breast Cancer (TNBC) subtype remain limited and the outcome for patients with advanced TNBC is very poor. The standard of care is chemotherapy, but approximately 50% of tumors develop resistance.

Methods
We performed gene expression profiling of 58 TNBC tumor samples by microarray, comparing chemosensitive with chemoresistant tumors, which revealed that one of the top upregulated genes was TGFβ2. A connectivity mapping bioinformatics analysis predicted that the SRC inhibitor Dasatinib was a potential pharmacological inhibitor of chemoresistant TNBCs. Claudin-low TNBC cell lines were selected to represent poor-outcome, chemoresistant TNBC, for in vitro experiments and in vivo models.

Results
In vitro, we identified a signaling axis linking SRC, AKT and ERK2, which in turn upregulated the stability of the transcription factors, Slug and Snail. Slug was shown to repress TGFβ2-antisense 1 to promote TGFβ2 signaling, upregulating cell survival via apoptosis and DNA-damage responses. Additionally, an orthotopic allograft in vivo model demonstrated that the SRC inhibitor Dasatinib reduced tumor growth as a single agent, and enhanced responses to the TNBC mainstay drug, Epirubicin.

Conclusion
Targeting the SRC-Slug-TGFβ2 axis may therefore lead to better treatment options and improve patient outcomes in this highly aggressive subpopulation of TNBCs.
Factors affecting the accuracy of prehospital triage application and prehospital scene time in simulated mass casualty incidents
Authors: Carenzo Luca , Gamberini Lorenzo , Crimaldi Federico , Colombo Davide , Ingrassia Pier Luigi , Ragazzoni Luca , Della Corte Francesco , Caviglia Marta 
Published: September 2024

Abstract
Background
The contemporary management of mass casualty incidents (MCIs) relies on the effective application of predetermined, dedicated response plans based on current best evidence. Currently, there is limited evidence regarding the factors influencing the accuracy of first responders (FRs) in applying the START protocol and the associated prehospital times during the response to MCIs. The objective of this study was to investigate factors affecting FRs’ accuracy in performing prehospital triage in a series of simulated mass casualty exercises. Secondly, we assessed factors affecting triage-to-scene exit time in the same series of exercises.

Methods
This retrospective study focused on simulated casualties in a series of simulated MCIs Full Scale Exercises. START triage was the triage method of choice. For each Full-Scale Exercise (FSEx), collected data included exercise and casualty-related information, simulated casualty vital parameters, simulated casualty anatomic lesions, scenario management times, and responder experience.

Results
Among the 1090 casualties included in the primary analysis, 912 (83.6%) were correctly triaged, 137 (12.6%) were overtriaged, and 41 (3.7%) were undertriaged. The multinomial regression model indicated that increasing heart rate (RRR = 1.012, p = 0.008), H-AIS (RRR = 1.532, p < 0.001), and thorax AIS (T-AIS) (RRR = 1.344, p = 0.007), and lower ISS (RRR = 0.957, p = 0.042) were independently associated with overtriage. Undertriage was significantly associated with increasing systolic blood pressure (RRR = 1.013, p = 0.005), AVPU class (RRR = 3.104 per class increase), and A-AIS (RRR = 1.290, p = 0.035). The model investigating the factors associated with triage-to-scene departure time showed that the assigned prehospital triage code red (TR = 0.841, p = 0.002), expert providers (TR = 0.909, p = 0.015), and higher peripheral oxygen saturation (TR = 0.998, p < 0.001) were associated with a reduction in triage-to-scene departure time. Conversely, increasing ISS was associated with a longer triage-to-scene departure time (TR = 1.004, 0.017).

Conclusions
Understanding the predictors influencing triage and scene management decision-making by healthcare professionals responding to a mass casualty may facilitate the development of tailored training pathways regarding mass casualty triage and scene management.
Sex differences in symptoms following the administration of BNT162b2 mRNA COVID-19 vaccine in children below 5 years of age in Germany (CoVacU5): a retrospective cohort study
Authors: Moor Jeanne , Toepfner Nicole , von Meißner Wolfgang C. G. , Berner Reinhard , Moor Matthias B. , Kublickiene Karolina , Strumann Christoph , Chao Cho-Ming 
Published: September 2024

Abstract
Background
Sex differences exist not only in the efficacy but also in adverse event rates of many vaccines. Here we compared the safety of BNT162b2 vaccine administered off-label in female and male children younger than 5 years in Germany.

Methods
This is a retrospective cohort study, in which we performed a post-hoc analysis of a dataset collected through an authentication-based survey of individuals having registered children aged 0-<5 years for vaccination against SARS-CoV-2 in six private practices and/or two lay person-initiated vaccination campaigns. We analyzed the safety profiles of the first 3 doses of 3–10 µg BNT162b2. Primary outcome was comparison in frequencies of 4 common post-vaccination symptom categories such as local, general, musculoskeletal symptoms and fever. Data were analyzed according to sex in bivariate analyses and regression models adjusting for age, weight, and dosage. Interaction between sex and BNT162b2 dosage was assessed. An active-comparator analysis was applied to compare post-vaccination symptoms after BNT162b2 versus non-SARS-CoV-2 vaccines.

Results
The dataset for the present analysis consisted of 7801 participants including 3842 females (49%) and 3977 males (51%) with an age of 3 years (median, interquartile: 2 years). Among individuals receiving 3 µg BNT162b2, no sex differences were noted, but after a first dose of 5–10 µg BNT162b2, local injection-site symptoms were more prevalent in girls compared to boys. In logistic regression, female sex was associated with higher odds of local symptoms, odds ratio (OR) of 1.33 (95% confidence interval [CI]: 1.15–1.55, p < 0.05) and general symptoms with OR 1.21 (95% CI: 1.01–1.44, p < 0.05). Following non-BNT162b2 childhood vaccinations, female sex was associated with a lower odds of post-vaccination musculoskeletal symptoms (OR: 0.29, 95% CI: 0.11–0.82, p < 0.05). An active comparator analysis between BNT162b2 and non-SARS-CoV-2 vaccinations revealed that female sex positively influenced the association between BNT162b2 vaccine type and musculoskeletal symptoms.

Conclusions
Sex differences exist in post-vaccination symptoms after BNT162b2 administration even in young children. These are of importance for the conception of approval studies, for post-vaccination monitoring and for future vaccination strategies (German Clinical Trials Register ID: DRKS00028759).
Effects of different loads of Pinus pinaster Ait. litter and ash on the germination and growth of Cistus ladanifer L
Authors: Piñas-Bonilla Paula , Zavala Gonzalo , Pérez Beatriz , Luna Belén 
Published: September 2024

Abstract
Key message
Cistus ladanifer L. shows an extraordinary plasticity of germination and growth. Fire promotes the regeneration of C. ladanifer by triggering its germination through thermal shock as well as by enhancing its seedling growth through the addition of ashes. On the contrary, stacking of Pinus pinaster Ait. leaf litter may hinder seedling establishment, at least in the first months after germination.

Context
Pinus pinaster Ait. is affected by forest fires in the Mediterranean basin. Its extreme flammability is due to the high spatial continuity together with the massive accumulation of leaf litter. Cistus ladanifer L. is a species which is widely distributed in the west Mediterranean region where it can form vast shrublands and flourish under these pinewoods. Although high temperatures associated with the occurrence of fire trigger germination of C. ladanifer, knowledge on how other factors, such as the presence of litter on the forest floor or the ash left after the fire, influence germination and seedling growth is essential to improve land management plans.

Aims
The main objective of this study was to determine the effects of different loads of litter from P. pinaster and ash from their combustion on the germination and growth of seedlings of C. ladanifer.

Methods
Two experiments were carried out to assess the effect of heat shock (100 °C for 10 min) and two loads of litter and ash from P. pinaster (control, high and low loads of litter, high and low loads of ash) on the germination and growth after 2 and 4 months of C. ladanifer.

Results
Heat shock significantly increased the germination of C. ladanifer. In contrast, the addition of litter and ash had no effect on total germination but affected the growth of the seedlings coming from seeds exposed to heat shock. Litter treatments reduced biomass of 2 months seedlings and ash increased biomass of 4 months seedlings.

Conclusion
C. ladanifer is a species favoured by fire in different ways depending on the stage of regeneration. Germination is promoted by heat shock while seedling growth is favoured by ash nutrients. In contrast, pine leaf litter hinders seedling growth, although this effect disappears 4 months after germination. Alternative forest management practices to prescribed fires are recommended if preventing the spread of Cistus is a priority.
Coping with COVID-19: a prospective cohort study on young Australians' anxiety and depression symptoms from 2020–2021
Authors: Orozco Ana , Thomas Alexander , Raggatt Michelle , Scott Nick , Eddy Sarah , Douglass Caitlin , Wright Cassandra J. C. , Spelman Tim , Lim Megan S. C. 
Published: September 2024

Abstract
Background
Studies have shown that the coronavirus (COVID-19) pandemic negatively impacted the mental health of young Australians. However, there is limited longitudinal research exploring how individual factors and COVID-19 related public-health restrictions influenced mental health in young people over the acute phase of the COVID-19 pandemic. This study aimed to identify risk and protective factors associated with changes in individual symptoms of anxiety and depression among young Australians during the COVID-19 pandemic.

Methods
This prospective cohort study collected data on anxiety and depression symptoms of young Australians aged 15–29 years old using the Depression, Anxiety and Stress Scale short form (DASS-21). We delivered four online questionnaires from April 2020 to August 2021 at intervals of 3, 6, and 12 months after the initial survey. We implemented linear mixed-effects regression models to determine the association among demographic, socioeconomic, lifestyle and COVID–19 public health restrictions related factors and the severity of anxiety and depression symptoms over time.

Results
Analyses included 1936 young Australians eligible at baseline. There was a slight increase in DASS-21 anxiety mean scores from timepoint 3 to timepoint 4. DASS-21 depression scores showed slight fluctuations across timepoints with the highest mean score observed in timepoint 2. Factors associated with increases in anxiety and depression severity symptoms included LGBTQIA + identity, financial insecurity both before and during the pandemic, higher levels of loneliness, withdrawal or deferral of studies, spending more time on social media, and difficulties to sleep. Risk factors for only depression symptoms include unemployment during COVID-19 pandemic and being in lockdown. Living with someone was a protective factor for both anxiety and depression symptoms, pre-COVID-19 unemployment for depression symptoms, and older age and unemployment during the pandemic for anxiety symptoms.

Conclusion
These findings indicate that during the first year of the pandemic in Australia, there were significant changes in young people’s mental health which were associated with multiple demographic, socioeconomic, lifestyle, and lockdown factors. Hence, in future public health crises, we suggest more inclusive guidelines that involve young people in their development and implementation ensuring that their unique perspectives and needs are adequately considered.
Gender differentials in primary processing and market participation by mopane worm harvesters in Zimbabwe: insights from the COVID-19 pandemic phase
Authors: Musara Joseph P. , Bahta Yonas T. , Mapuranga Rangarirai , Musiniwa Fredy , Abu Hatab Assem , Owusu-Sekyere Enoch 
Published: September 2024

Abstract
Background
Gender disparities in access to inputs, markets, financial inclusion, and participation in strategic value chains are major developmental challenges in emerging economies. Participation in the edible insect value chain has become an essential source of income, food, and nutrition in some African countries. This paper uses a bivariate probit model to examine the gender differentials for primary mopane worm harvesters’ participation in primary processing and market participation during COVID-19 in Southeastern Zimbabwe. Using a structured questionnaire, the data were gathered from 393 primary harvesters in five purposively selected wards in the Gwanda District of Zimbabwe. This study examines the gender differentials for primary mopane worm harvesters’ participation in primary processing and market participation during COVID-19 in Southeastern Zimbabwe.

Results
Results show that women are likelier to participate in primary value addition to preparing for the lean season opportunities. There are gender differentials in the participation in markets during COVID-19. Results show a significant negative relationship between participants' ages and female engagement in mopane processing and a positive correlation with female involvement in lean COVID-19 season marketing. Male harvesters’ participation in the lean market during the COVID-19 pandemic was significantly correlated positively with age and education level, while the choice to participate in the lean market was negatively correlated with the dependency ratio.

Conclusions
Collaborative, community-centric, and gender-accommodative development of the mopane worm value chain is important. Focal issues are on supporting primary value addition for lean season market participation and during market shocks such as COVID-19. This can be a leap towards gender equality and improving livelihoods of women and men in mopane harvesting areas. The study recommends marketing and district-specific policies explicitly addressing mopane worm harvesting and marketing affects market participation and primary value-addition decisions.
Protection and Heat Insulation Performance Comparison using Insulation Formwork in Winter
Authors: Lim Myung-Kwan , Nam Kyung-Yong , Choi Hyeonggil 
Published: September 2024

AbstractConcrete pouring in winter is critical to both concrete manufacturers and end users owing to the possibility of concrete damage due to cold weather. In this context, various methods have been used to prevent frost damage to concrete in winter, including adjusting the concrete mix using a chemical admixture and heat-curing with tents. Of these methods, the insulated-gang-form approach does not require concrete-mix adjustment via a chemical-admixture addition. Furthermore, its positive effect on the initial quality of concrete during concrete construction in winter has previously been confirmed. In this study, the power consumption of the conventional gang form was compared with that of the insulated gang form to evaluate the efficiency of the two protection methods. A thermal vision camera was used to examine the surface heat loss of the gang forms after concrete pouring. The insulated gang form significantly outperformed the conventional one through its significantly reduced power consumption and reduced surface heat loss. These findings can contribute to the standardization of insulated gang form application to concrete protection in cold-weather conditions.
Translation, cultural adaptation and validation of the Tamil version of the Cardiff Acne Disability Index (CADI) in Sri Lanka
Authors: Prathapan Shamini , Liyanage Achala , Logeeswaran Sailakshmi , Ratnayake Wathsala , Devapriya Lilangi , Perera Jennifer 
Published: September 2024

AbstractBackgroundAssessment of QoL has become an essential component in the holistic care of patients with acne. The Cardiff Acne Disability Index (CADI) is used globally to assess quality of life (QoL) in patients with acne. This study was done to validate CADI in Tamil, as 90 million of the global population are native speakers and Tamil is an official language of several countries.MethodsCADI was translated and validated into Tamil according to published guidelines. The Tamil versions of both CADI and Dermatology Life Quality Index (DLQI), was administered to 150 Sri Lankan young adults with acne. The clinical severity was assessed using the Global Acne Grading System (GAGS). Discriminant validity was tested by comparing the results of CADI with those of GAGS and DLQI, using reliability, validity, Cronbach’s alpha, and Spearman’s correlation coefficient measurements. Construct validity was assessed by factor analysis.Results70% were female, and the mean age was 25.1 (SD, 5.2). The majority (91.3%) had acne of mild to moderate severity when measured by GAGS. CADI-Tamil showed high internal consistency and reliability (Cronbach’s alpha coefficient = 0.83). The CADI total score showed a strong correlation (0.86) with that of DLQI. The correlation between CADI and GAGS was low, whereas CADI had a high and significant correlations with the DLQI. The construct validity explained 61% of the variability.ConclusionsThe CADI-Tamil is a reliable and valid tool for assessing the QoL of Tamil speaking patients with acne. This tool will help clinicians understand the patient’s perspective on acne.