bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 16-Year Journey in the Study of Rheumatoid Hand Disease
Authors: Chung Kevin C. , Kotsis Sandra V. 
Published: March 2017

Summary:
Evidence-based medicine is a relatively new concept in hand surgery. A lack of high-level evidence often leads to uncertainty in the effectiveness of various procedures and regional variation in their use. Rheumatoid hand surgery has been plagued by a lack of quality data that has caused controversy between rheumatologists and hand surgeons. Research over the past 16 years has strived to provide data that can be used to provide evidence-based care for rheumatoid arthritis patients. The Silicone Arthroplasty in Rheumatoid Arthritis study is a prospective, long-term cohort study of rheumatoid arthritis patients with severe metacarpophalangeal joint deformity who have elected to undergo or not to undergo metacarpophalangeal joint arthroplasty; the study was funded for 10 years by the National Institutes of Health and has provided invaluable results on the effectiveness of this procedure in terms of outcomes and cost, improving knowledge for both physicians and patients.
The Impact of Laparoscopic-assisted Colorectal Surgery Using 3-dimensional Reconstruction for Highly Obese Patients With Colorectal Cancer
Authors: Miyamoto Ryoichi , Tadano Sosuke , Sano Naoki , Inagawa Satoshi , Yamamoto Masayoshi 
Published: March 2017

Objectives:
During laparoscopic-assisted colorectal surgery (LACS), precise recognition of the anatomic variations and relationships among tumor and vessels is required. However, in highly obese patients, it is more difficult to grasp the surgical anatomy due to the presence of dense mesenteric fat tissue. We utilized a 3-dimensional (3D) reconstructed image for preoperative simulation and intraoperative navigation for LACS. In this study, we examined the correlation between patient obesity and 3D-simulated perioperative outcomes.

Materials and Methods:
We retrospectively analyzed 124 patients who underwent LACS using 3D surgical simulation at Tsukuba Medical Center Hospital. We sequentially divided our cohort into 2 groups: patients with a low body mass index (BMI<25 kg/m2, n=60) and patients with a high BMI (BMI ≥25 kg/m2, n=64). Patient characteristics and perioperative outcomes, including conversion rate, postoperative complications, operating time, intraoperative blood loss, and length of postoperative hospital stay, were compared for these 2 groups.

Results:
There were no significant differences in patient background between the 2 groups.
We found it more difficult to grasp the surgical anatomy, including vessel arrangement, for high-BMI patients than for low-BMI patients because of the dense mesenteric fat tissue in high-BMI patients. There were no significant differences between the 2 groups with respect to perioperative outcomes.

Conclusions:
The utilized reconstructed 3D images were useful for understanding anatomic relationships, including vessel arrangement, during LACS, particularly in highly obese patients.
Can human embryonic stem cell-derived stromal cells serve a starting material for myoblasts?
Authors: Ando Yu , Saito Marie , Machida Masakazu , Noro Chikako , Takahashi Masataka , Toyoda Masashi , Umezawa Akihiro 
Published: March 2017

ABSTRACTA large number of myocytes is necessary to treat intractable muscular disorders such as Duchenne muscular dystrophy with cell-based therapies. However, starting materials for cellular therapy products such as myoblasts, marrow stromal cells, menstrual blood-derived cells and placenta-derived cells have a limited lifespan and cease to proliferatein vitro. From the viewpoints of manufacturing and quality control, cells with a long lifespan are more suitable as a starting material. In this study, we generated stromal cells for future myoblast therapy from a working cell bank of human embryonic stem cells (ESCs). The ESC-derived CD105+cells with extensivein vitroproliferation capability exhibited myogenesis and genetic stabilityin vitro. These results imply that ESC-derived CD105+cells are another cell source for myoblasts in cell-based therapy for patients with genetic muscular disorders. Since ESCs are immortal, mesenchymal stromal cells generated from ESCs can be manufactured at a large scale in one lot for pharmaceutical purposes.
On the relationship between epistasis and genetic variance-heterogeneity
Authors: Forsberg Simon , Carlborg Örjan 
Published: March 2017

AbstractEpistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two. This includes an introduction to the relationship between epistatic gene-action, statistical epistasis and genetic variance heterogeneity and a brief discussion about how other genetic processes than epistasis can also give rise to genetic variance heterogeneity.HighlightGenetic effects on the trait variance, rather than the mean, have been found in several studies. Here we discuss how this sometimes, but not always, can be caused by epistasis.
Discovering complete quasispecies in bacterial genomes
Authors: Bertels Frederic , Gokhale Chaitanya S. , Traulsen Arne 
Published: March 2017

ABSTRACTMobile genetic elements can be found in almost all genomes. Possibly the most common non-autonomous mobile genetic elements in bacteria are REPINs that can occur hundreds of times within a genome. The sum of all REPINs within a genome are an evolving populations because they replicate and mutate. We know the exact composition of this population and the sequence of each member of a REPIN population, in contrast to most other biological populations. Here, we model the evolution of REPINs as quasispecies. We fit our quasispecies model to ten different REPIN populations from ten different bacterial strains and estimate duplication rates. We find that our estimated duplication rates range from about 5 × 10−9to 37 × 10−9duplications per generation per genome. The small range and the low level of the REPIN duplication rates suggest a universal trade-off between the survival of the REPIN population and the reduction of the mutational load for the host genome. The REPIN populations we investigated also possess features typical of other natural populations. One population shows hallmarks of a population that is going extinct, another population seems to be growing in size and we also see an example of competition between two REPIN populations.
From word models to executable models of signaling networks using automated assembly
Authors: Gyori Benjamin M , Bachman John A , Subramanian Kartik , Muhlich Jeremy L , Galescu Lucian , Sorger Peter K 
Published: March 2017

AbstractWord models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to building computational models directly from natural language using automated assembly. Molecular mechanisms described in simple English are read by natural language processing algorithms, converted into an intermediate representation and assembled into executable or network models. We have implemented this approach in the Integrated Network and Dynamical Reasoning Assembler (INDRA), which draws on existing natural language processing systems as well as pathway information in Pathway Commons and other online resources. We demonstrate the use of INDRA and natural language to model three biological processes of increasing scope: (i) p53 dynamics in response to DNA damage; (ii) adaptive drug resistance in BRAF-V600E mutant melanomas; and (iii) the RAS signaling pathway. The use of natural language for modeling makes routine tasks more efficient for modeling practitioners and increases the accessibility and transparency of models for the broader biology community.Standfirst textINDRA uses natural language processing systems to read descriptions of molecular mechanisms and assembles them into executable models.HighlightsINDRA decouples the curation of knowledge as word models from model implementationINDRA is connected to multiple natural language processing systems and can draw on information from curated databasesINDRA can assemble dynamical models in rule-based and reaction network formalisms, as well as Boolean networks and visualization formatsWe used INDRA to build models of p53 dynamics, resistance to targeted inhibitors of BRAF in melanoma, and the Ras signaling pathway from natural language
Development of a web-based system for managing suppliers’ performance and knowledge sharing in construction project
Authors: Qian Li Zi , Chen Tan Hai , Anumba Chimay , Choy Chia Fah 
Published: March 2017

PurposeThe purpose of this paper is to introduce a web-based system that provides an efficient means for managing suppliers’ performance which also facilitates the leveraging of suppliers’ knowledge for the benefit of the on-going projects.Design/methodology/approachCase study approach is adopted. In total, 12 semi-structured interviews are conducted with Malaysia-based public listed construction companies to study their current practice and the requirements for the development of an information and communication technology (ICT) aided system for the purpose. Subsequently, a web-based system for managing suppliers’ performance is developed using ASP.net and MSSQL database.FindingsMost of the case study companies are found to have low levels of ICT adoption and still resort to handling the majority of the tasks involved in the selection and management of suppliers’ performance manually. An ICT-based system that can improve the recording of important information about the suppliers, provide a function for supplier selection and facilitate the capture of useful reusable knowledge of the suppliers is needed.Originality/valueThe paper has shown empirically that a web-based suppliers’ performance management system eases the supplier selection process and the monitoring of suppliers’ performance. In addition, it demonstrates how such systems can be designed to capture and facilitate the leveraging of suppliers’ knowledge, and how suppliers’ knowledge contribution can be recognised as part of their performance. The system adopts a novel two-way communication model which provides the suppliers the access to their own performance records to identify room for improvements.
Improving the cost estimates of complex projects in the project-based industries
Authors: Sridarran Pournima , Keraminiyage Kaushal , Herszon Leon 
Published: March 2017

Purpose
Project-based industries face major challenges in controlling project cost and completing within the budget. This is a critical issue as it often connects to the main objectives of any project. However, accurate estimation at the beginning of the project is difficult. Scholars argue that project complexity is a major contributor to cost estimation inaccuracies. Therefore, recognising the priorities of acknowledging complexity dimensions in cost estimation across similar industries is beneficial in identifying effective practices to reduce cost implications. Hence, the purpose of this paper is to identify the level of importance given to different complexity dimensions in cost estimation and to recognise best practices to improve cost estimation accuracy.

Design/methodology/approach
An online questionnaire survey was conducted among professionals including estimators, project managers, and quantity surveyors to rank the identified complexity dimensions based on their impacts in cost estimation accuracy. Besides, in-depth interviews were conducted among experts and practitioners from different industries, in order to extract effective practices to improve the cost estimation process of complex projects.

Findings
Study results show that risk, project and product size, and time frame are the high-impact complexity dimensions on cost estimation, which need more attention in reducing unforeseen cost implications. Moreover, study suggests that implementing a knowledge sharing system will be beneficial to acquire reliable and adequate information for cost estimation. Further, appropriate staffing, network enhancement, risk management, and circumspect estimation are some of the suggestions to improve cost estimation of complex projects.

Originality/value
The study finally provides suggestions to improve cost estimation in complex projects. Further, the results are expected to be beneficial to learn lessons from different industries and to exchange best practices.
From international travelling consumer to place ambassador
Authors: De Nisco Alessandro , Papadopoulos Nicolas , Elliot Statia 
Published: March 2017

Purpose
The purpose of this paper is to extend international marketing theory by examining country image effects simultaneously from the perspectives of Product-Country Image (PCI), Tourism Destination Image (TDI), and General Country Image (GCI), and by using tourism satisfaction as the central construct in a comprehensive model that investigates post-visit effects in both the product and tourism domains.

Design/methodology/approach
International tourists from multiple countries were intercepted at the end of a tourism trip and interviewed in-person using a structured questionnaire, resulting in 498 usable responses for data analysis. The model comprised seven constructs measured with 28 variables and was tested with structural equation modelling.

Findings
The study uncovers a number of cross-effects between a country as destination and as producer, and establishes tourism satisfaction as a core construct that is relevant to both the tourism and product facets of place image.

Practical implications
Above all, the study’s findings argue strongly in favour of greater coordination between the “product” and “tourism” sides of place marketing.

Originality/value
The study is original in its integrative analysis of GCI, PCI, and TDI constructs as antecedents and consequences of the tourism experience and, among other original contributions, is the first to investigate the direct link between product beliefs, tourism satisfaction, and post-visit product-related intentions.
What everybody knows: embodied information in serious leisure
Authors: Cox Andrew M. , Griffin Brian , Hartel Jenna 
Published: March 2017

PurposeThe purpose of this paper is to reconsider the role of the body in information in serious leisure by reviewing existing work in information behaviour that theorises the role of the body, and by drawing selectively on literature from beyond information studies to extend our understanding.Design/methodology/approachAfter finding a lack of attention to the body in most influential works on information behaviour, the paper identifies a number of important authors who do offer theorisations. It then explores what can be learnt by examining studies of embodied information in the hobbies of running, music and the liberal arts, published outside the discipline.FindingsAuto-ethnographic studies influenced by phenomenology show that embodied information is central to the hobby of running, both through the diverse sensory information the runner uses and through the dissemination of information by the body as a sign. Studies of music drawing on the theory of embodied cognition, similarly suggest that it is a key part of amateur music information behaviour. Even when considering the liberal arts hobby, the core activity, reading, has been shown to be in significant ways embodied. The examples reveal how it is not only in more obviously embodied leisure activities such as sports, in which the body must be considered.Research limitations/implicationsEmbodied information refers to how the authors receive information from the senses and the way the body is a sign that can be read by others. To fully understand this, more empirical and theoretical work is needed to reconcile insights from practice theory, phenomenology, embodied cognition and sensory studies.Originality/valueThe paper demonstrates how and why the body has been neglected in information behaviour research, reviews current work and identifies perspectives from other disciplines that can begin to fill the gap.
Working framework of semantic interoperability for CRIS with heterogeneous data sources
Authors: Leiva-Mederos Amed , Senso Jose A. , Hidalgo-Delgado Yusniel , Hipola Pedro 
Published: March 2017

Purpose
Information from Current Research Information Systems (CRIS) is stored in different formats, in platforms that are not compatible, or even in independent networks. It would be helpful to have a well-defined methodology to allow for management data processing from a single site, so as to take advantage of the capacity to link disperse data found in different systems, platforms, sources and/or formats. Based on functionalities and materials of the VLIR project, the purpose of this paper is to present a model that provides for interoperability by means of semantic alignment techniques and metadata crosswalks, and facilitates the fusion of information stored in diverse sources.

Design/methodology/approach
After reviewing the state of the art regarding the diverse mechanisms for achieving semantic interoperability, the paper analyzes the following: the specific coverage of the data sets (type of data, thematic coverage and geographic coverage); the technical specifications needed to retrieve and analyze a distribution of the data set (format, protocol, etc.); the conditions of re-utilization (copyright and licenses); and the “dimensions” included in the data set as well as the semantics of these dimensions (the syntax and the taxonomies of reference). The semantic interoperability framework here presented implements semantic alignment and metadata crosswalk to convert information from three different systems (ABCD, Moodle and DSpace) to integrate all the databases in a single RDF file.

Findings
The paper also includes an evaluation based on the comparison – by means of calculations of recall and precision – of the proposed model and identical consultations made on Open Archives Initiative and SQL, in order to estimate its efficiency. The results have been satisfactory enough, due to the fact that the semantic interoperability facilitates the exact retrieval of information.

Originality/value
The proposed model enhances management of the syntactic and semantic interoperability of the CRIS system designed. In a real setting of use it achieves very positive results.
State of business statistics education in MENA region
Authors: Hijazi Rafiq , Zoubeidi Taoufik 
Published: March 2017

PurposeThe purpose of this study is to investigate the state of undergraduate business statistics education in the Middle East and North Africa (MENA) and assess its alignment with the best practices in equipping business graduates with the knowledge and skills demanded by the labor market.Design/methodology/approachA survey of 108 instructors from 80 business schools in 17 MENA countries was conducted to gauge information on the delivery of business statistics courses. The survey results were benchmarked to a proposed framework for best practices in business statistics education.FindingsThe gap analysis identified deficiencies in the delivery of business statistics education in the region as compared to international best practices. This study revealed a need to revise statistics education as part of a comprehensive reform of business education with the aim to meet international quality standards in business education.Research limitations/implicationsThe study relied on the self-reported responses of business statistics instructors in MENA. One hundred eight questionnaires were completed, corresponding to a response rate of 40 per cent. Moreover, the study did not measure the effectiveness of teaching and learning in business statistics courses.Practical implicationsRecommendations from the study are intended to guide business statistics instructors in improving the quality of business statistics education through adopting more effective ways to enhance student learning experience and graduate employability.Originality/valueThis study is the first of its kind to investigate and assess the business statistics education in the MENA region.
Teaching giants to learn: lessons from army learning in World War II
Authors: Visser Max 
Published: March 2017

Purpose
This paper aims to discuss the “truism” that learning organizations cannot be large organizations and, conversely, that large organizations cannot be learning organizations. This paper analyzes learning in the German and US armies in the Second World War, based on a four-dimensional model of the learning organization.

Design/methodology/approach
The paper entails a secondary analysis of historical and military sources and data.

Findings
It is found that the German and US armies differed in learning capacity, which can be plausibly, but not exclusively, related to differences in the battlefield performance between those armies in the Second World War.

Research limitations/implications
The research scope of the paper is limited to the analysis of two particular armies in the Second World War. Implications of theory reside in the importance of organizational learning capacity and its dimensions for learning in current organizations.

Practical implications
The paper has clear practical implications for large organizations wishing to become effective and responsible learning organizations.

Originality/value
This is among the first organizational papers to analyze army learning in the Second World War and to derive lessons from that analysis for current large organizations.
Why is organizing human resource development so problematic?
Authors: Poell Rob F. , van der Krogt Ferd 
Published: March 2017

PurposeHuman resource development (HRD) is an important field within management. Developing employees is often regarded as an instrument to improve the internal labor market and support organizational change. Organizing HRD to these ends, however, is frequently a problematic affair, in terms of training effectiveness, participant motivation and added value. This study, which consists of two parts, aims to investigate the question of why this is the case. In this first part, the problem is stated and the backgrounds and basic tenets of learning-network theory are addressed.Design/methodology/approachThe paper first describes three approaches to organizing HRD, namely, as a training issue: customization by HRD practitioners; as a learning issue: didactic self-direction by employees; and as a strategic issue for employees and managers: micro-politics. The learning-network theory is then introduced as an integration of these three approaches. It presents a number of key organizational actors that organize four HRD processes, each operating strategically in their own way.FindingsOrganizing HRD is mostly viewed as designing training courses and instruction sessions for employees; it is also predominantly understood as a tool of management. A network perspective on organizing HRD is better able to guide organizational actors than other approaches can.Originality/valueThe study argues that organizing HRD needs to take into account learning experiences that employees can gain from participating in work and career development as well (besides formal training); moreover, that employees’ HRD strategies are at least as important as those used by line managers and HR practitioners.