bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis, Crystal Structure, and Physical Properties of the Gd3BiO3 and Gd8Bi3O8 Phases.
Authors: Forbes Scott , Yuan Fang , Kosuda Kosuke , Kolodiazhnyi Taras , Mozharivskyj Yurij 
Published: March 2016

AbstractSince Gd3BiO3 (I) is only observed as a minor impurity, Gd8Bi3O8 (II) is prepared by solid state reaction of a 1:1 molar mixture of GdBi and Gd2O3 (Ta ampoules in Mo susceptor under vacuum, 1300 °C, 24 h).
ChemInform Abstract: Structures and Magnetic Properties of New Fluorite‐Related Quaternary Rare Earth Oxides LnY2TaO7 and LaLn2RuO7 (Ln: Rare Earths).
Authors: Hinatsu Yukio , Doi Yoshihiro 
Published: March 2016

AbstractPolycrystalline samples of LnY2TaO7 (Ln: La—Dy) are prepared by repeated firing of stoichiometric amounts of Ln2O3 (Pr6O11 and Tb4O7), Y2O3, and Ta2O5 in air (1400—1600 °C, 12 h).
ChemInform Abstract: RNi8Si3 (R: Gd, Tb): Novel Ternary Ordered Derivatives of the BaCd11 Type.
Authors: Pani M. , Morozkin A. V. , Yapaskurt V. O. , Provino A. , Manfrinetti P. , Nirmala R. , Malik S. K. 
Published: March 2016

AbstractThe title compounds are prepared by arc melting of stoichiometric amounts of the elements under Ar followed by annealing (Ta foil in evacuated silica tubes, 1273 K, 5—7 d).
ChemInform Abstract: Li2C2, a High‐Capacity Cathode Material for Lithium Ion Batteries.
Authors: Tian Na , Gao Yurui , Li Yurong , Wang Zhaoxiang , Song Xiaoyan , Chen Liquan 
Published: March 2016

AbstractOrthorhombic Li2C2 as a potential cathode material for Li batteries is prepared by spark plasma sintering (SPS) of a 1.07:1 mixture of Li and C powder under vacuum (1.6 x 10‐2 Pa, 600 °C, 1 h) followed by a second SPS consolidation step at 300 MPa (350 °C, 2 min).
ChemInform Abstract: In Search of the Elusive IrB2: Can Mechanochemistry Help?
Authors: Xie Zhilin , Blair Richard G. , Orlovskaya Nina , Cullen David A. , Lapidus Saul H. , Kata Dariusz , Rutkowski Pawel , Lis Jerzy 
Published: March 2016

AbstractPreviously unknown hexagonal ReB2‐type IrB2 is mechanochemically produced along with new orthorhombic IrB and IrB1.35 (weight fraction of 9.2:5.2:85.6%) by high energy ball milling of the elements in the molar ratio Ir:B = 1:3 (30 h) followed by annealing (1050 °C, 48 h) for the removal of strain induced during ball milling.
ChemInform Abstract: Copper‐Promoted Cycloaddition of α‐Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzo[d]imidazothiazoles.
Authors: Wang Jian , Li Jing , Zhu Qiang 
Published: March 2016

AbstractDepending on the substituent at C‐2 either benzo[d]imidazo[2,1‐b]thiazol or benzo[d]imidazo[5,1‐b]thiazol derivatives are accessible.
ChemInform Abstract: Rice Husk Derived Nanosilica Supported Cu(II) Complex: An Efficient Heterogeneous Catalyst for Oxidation of Alcohols Using TBHP.
Authors: Gogoi Nibedita , Begum Tahshina , Dutta Smarika , Bora Utpal , Gogoi Pradip K. 
Published: March 2016

AbstractVarious primary and secondary alcohols are oxidized using a novel heterogenized catalyst of Cu(II) complex immobilized onto nanosilica obtained from rice husk.
ChemInform Abstract: Transition‐Metal‐Mediated Synthesis of Trifluoroethyl Aryl Ethers.
Authors: Huang Yangjie , Huang Ronglu , Weng Zhiqiang 
Published: March 2016

AbstractThe copper(I)‐mediated reaction delivers trifluoroethyl, pentafluoropropyl‐, and tetrafluoropropylaryl‐, and a broad range of hetarylethers in generally high yields.
ChemInform Abstract: Catalyst‐Free Regioselective C‐3 Thiocyanation of Imidazopyridines.
Authors: Yang Daoshan , Yan Kelu , Wei Wei , Li Guoqing , Lu Shenglei , Zhao Caixia , Tian Laijin , Wang Hua 
Published: March 2016

AbstractA direct approach for the highly regioselective thiocyanation of imidazoheterocycles through C—H functionalization is realized.
ChemInform Abstract: Photocatalytic C—F Alkylation; Facile Access to Multifluorinated Arenes.
Authors: Singh A. , Kubik J. J. , Weaver J. D. 
Published: March 2016

AbstractThe photocatalytic reductive alkylation of pentafluorides such as (I) and (IV) with alkenes in the presence of 1.2 equiv.
ChemInform Abstract: Dimethylzinc‐Initiated Radical Coupling of β‐Bromostyrenes with Ethers and Amines.
Authors: Soelvhoej Amanda , Ahlburg Andreas , Madsen Robert 
Published: March 2016

AbstractThe MnCl2‐catalyzed reaction of β‐bromostyrene with ethers (II) and (VII) as a reactant and solvent affords pure (E)‐adducts (III) and (VIII), resp., in moderate to good yields.
ChemInform Abstract: Palladium‐Catalyzed Carbonylation of Aryl Iodides with Sulfinamides.
Authors: Belfrage Anna Karin , Wakchaure Prasad , Larhed Mats , Sandstroem Anja 
Published: March 2016

AbstractA procedure for the Pd‐catalyzed coupling of sufinamides with aryl iodides and carbon monoxide is presented to give acyl‐sulfinamides.
ChemInform Abstract: B(OCH2CF3)3‐Mediated Direct Amidation of Pharmaceutically Relevant Building Blocks in Cyclopentyl Methyl Ether.
Authors: Karaluka Valerija , Lanigan Rachel M. , Murray Paul M. , Badland Matthew , Sheppard Tom D. 
Published: March 2016

AbstractAn improved procedure is developed for the direct amidation with B(OCH2CF3)3 using cyclopentyl methyl ether as the solvent.
ChemInform Abstract: A Rapid and Selective Synthesis of α,α‐Fluorohalo Esters via Fluorohalogenative or Difluorinative Hydration of Ynol Ethers.
Authors: Hu Liang , Che Chao , Tan Ze , Zhu Gangguo 
Published: March 2016

AbstractThe selective trifunctionalization of CC triple bonds of ynol ethers (I) via Selectfluor‐mediated fluorohalogenative or difluorinative hydration is described.
ChemInform Abstract: Radical Solution to the Alkylation of the Highly Base‐Sensitive 1,1‐Dichloroacetone. Application to the Synthesis of Z‐Alkenoates and E,E‐Dienoates.
Authors: Anthore Lucile , Li Shiguang , White Lorenzo V. , Zard Samir Z. 
Published: March 2016

AbstractThe reaction of xanthate (I) and various alkenes can provide the access to functionalized gem‐α‐dichloroketones [e.g. (III)], which can be further derived to alkenoates [e.g. (VI) and (VIII)] and dienoates [e.g. (IX)].
ChemInform Abstract: Iron(III)‐Catalyzed Cycloisomerizations of Acetal—Vinylidenecyclopropanes: An Efficient Synthetic Route to 1,2‐Disubstituted Cyclobutenes.
Authors: Yang Song , Yuan Wei , Xu Qin , Shi Min 
Published: March 2016

AbstractThe Fe‐catalyzed cycloisomerization of vinylidenecyclopropanes in the presence of acetyl halide leads to 1,2‐disubstituted cyclobutenes such as (II)/(III), (V)/(VI), and (IX)/(X).
ChemInform Abstract: Ruthenium(II)‐Catalyzed C—H Functionalizations with Allenes: Versatile Allenylations and Allylations.
Authors: Nakanowatari Sachiyo , Ackermann Lutz 
Published: March 2016

AbstractThe allenylation of N‐methoxybenzamides (I), (IV), and (VI) is accompanied by cleavage of the directing group to afford 2‐allenyl benzamides.
ChemInform Abstract: A Strained Disilane‐Promoted Carboxylation of Organic Halides with CO2 under Transition‐Metal‐Free Conditions.
Authors: Mita Tsuyoshi , Suga Kenta , Sato Kaori , Sato Yoshihiro 
Published: March 2016

AbstractThe carboxylation of a wide range of organic iodides (40 examples) proceeds at an ambient CO2 atmosphere at room temperature within 2 hours.
ChemInform Abstract: Silica Supported Palladium‐Phosphine as a Reusable Catalyst for Alkoxycarbonylation and Aminocarbonylation of Aryl and Heteroaryl Iodides.
Authors: Mane Rajendra Shivaji , Sasaki Takehiko , Bhanage Bhalchandra Mahadeo 
Published: March 2016

AbstractThe catalyst can be reused up to five cycles without loss of catalytic activity and selectivity.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling Reaction of Azides with Isocyanides.
Authors: Zhang Zhen , Li Zongyang , Fu Bin , Zhang Zhenhua 
Published: March 2016

AbstractThe cross‐coupling reaction of isocyanides (II) with aryl, heteroaryl, benzyl, and alkyl azides leads to a variety of unsymmetrical carbodiimides in moderate to high yields.
ChemInform Abstract: One‐Pot Catalysis Using a Chiral Iridium Complex/Broensted Base: Catalytic Asymmetric Synthesis of Catalponol.
Authors: Suzuki Takeyuki , Ismiyarto Takeyuki , Ishizaka Yuka , Zhou Da‐Yang , Asano Kaori , Sasai Hiroaki 
Published: March 2016

AbstractBased on a tandem oxidation/aldol condensation reaction meso‐1,4‐tetralinediol is efficiently converted according to the title reaction.
ChemInform Abstract: Visible‐Light‐Promoted Photoredox Syntheses of α,β‐Epoxy Ketones from Styrenes and Benzaldehydes under Alkaline Conditions.
Authors: Li Jing , Wang David Zhigang 
Published: March 2016

AbstractThe title synthesis proceeds under synergistic actions of photocatalyst RuCl2(bipy)3.
ChemInform Abstract: Quaternary Stereogenic Centers Through Enantioselective Heck Arylation of Acyclic Olefins with Aryldiazonium Salts: Application in a Concise Synthesis of (R)‐Verapamil.
Authors: Oliveira Caio C. , Pfaltz Andreas , Correia Carlos Roque Duarte 
Published: March 2016

AbstractNovel chiral N,N ligands of the pyrimidine‐ and pyrazino‐oxazoline class are developed providing good to high enantioselectivities of the Heck reaction products.
ChemInform Abstract: The Iodine‐Mediated Highly Regioselective Synthesis of Angular and Linear Naphthofuroquinones.
Authors: Liu Suyou , Long Lijun , Xie Duoduo , Liu Lijun , Ma Dayou 
Published: March 2016

AbstractA simple protocol for the iodine‐mediated cyclization of naphthoquinones (I) to afford angularly fused naphthofuroquinones (II) is developed.
ChemInform Abstract: Zn(OTf)2 Promoted Rearrangement of 1,2‐Cyclopropanated Sugars with Amines: A Convenient Method for the Synthesis of 3‐Polyhydroxyalkyl‐Substituted Pyrrole Derivatives.
Authors: Shen Xudong , Xia Jianhui , Liang Peng , Ma Xiaofeng , Jiao Wei , Shao Huawu 
Published: March 2016

AbstractA rearrangement reaction of cyclopropanated sugars with alkylamines and arylamines promoted by 20 mol% of Zn(OTf)2 is reported.
ChemInform Abstract: An Exclusively trans‐Selective Chlorocarbamoylation of Alkynes Enabled by a Palladium/Phosphaadamantane Catalyst.
Authors: Le Christine M. , Hou Xiao , Sperger Theresa , Schoenebeck Franziska , Lautens Mark 
Published: March 2016

AbstractFor the first time, a highly efficient transition‐metal‐catalyzed atom‐economic chlorocarbamoylation reaction is reported to give access to pharmaceutically relevant methylene oxindoles, which are all obtained with E:Z selectivities <99:1.
ChemInform Abstract: Catalytic Asymmetric Nazarov Cyclization of Heteroaryl Vinyl Ketones Through a Crystallographically Defined Chiral Dinuclear Nickel Complex.
Authors: Takeda Takuya , Harada Shinji , Nishida Atsushi 
Published: March 2016

AbstractVarious pyrrole vinyl ketone derivatives are cyclized in generally very high yields and with very diastereomeric and high enantiomeric excesses.
ChemInform Abstract: N‐Imidazolylation of Sulfoximines from N‐Cyano Sulfoximines, 1‐Alkynes, and N‐Sulfonyl Azides.
Authors: Kim Sanghyuck , Kim Ji Eun , Lee Jinsub , Lee Phil Ho 
Published: March 2016

AbstractThe Rh‐catalyzed N‐imidazolylation of N‐sulfonyl‐1,2,3‐triazoles with several N‐cyano sulfoximines is studied.
ChemInform Abstract: Palladium‐Catalyzed ortho‐Nitration of 2‐Arylbenzoxazoles.
Authors: Qiao Hui‐Jie , Yang Fan , Wang Shi‐Wei , Leng Yu‐Ting , Wu Yang‐Jie 
Published: March 2016

AbstractThis method tolerates a variety of electron‐donating and electron‐withdrawing substituents in the 2‐aryl substituent.
ChemInform Abstract: Organocatalyzed Multicomponent Synthesis of Isoxazolidin‐5‐ones.
Authors: Berini Christophe , Sebban Muriel , Oulyadi Hassan , Sanselme Morgane , Levacher Vincent , Briere Jean‐Francois 
Published: March 2016

AbstractDABCO‐catalyzed three‐component reaction of Meldrum′s acid, N‐protected hydroxylamines and alkyl or aryl aldehydes gives the title compounds in good to high yields.
ChemInform Abstract: Acid‐Mediated [3 + 3] Cycloaddition of α‐EWG‐α‐Formyl Ketene‐S,S‐acetals and α‐Carbamoyl Ketene‐S,S‐acetals: A New Approach to 2‐Pyridone Derivatives.
Authors: Han Xiao‐Dan , Wang Hui‐Bin , Hu Ju‐Wu , Xiong Wei , Fu Jian‐Ping , Zhu Ren‐Guo , Deng Zhao‐Yang , Xu Guo‐Liang , Li Xiong‐Hui 
Published: March 2016

AbstractThis novel 2‐pyridone synthesis involves sequential Baylis—Hillman reaction, intramolecular cycloaddition, Michael addition, followed by an alkylthiol elimination process.
ChemInform Abstract: A One‐Pot Construction of Acridones by Rhodium Catalyzed Reaction of N‐Phenyl‐2‐(1‐sulfonyl‐1H‐1,2,3‐triazol‐4‐yl)aniline.
Authors: Xu Hua‐Dong , Pan Ying‐Peng , Ren Xin‐Tao , Zhang Ping , Shen Mei‐Hua 
Published: March 2016

AbstractThe construction of acridones involves a rhodium catalyzed decomposition of triazoles (I) and (III) to the corresponding rhodium carbenes followed by cyclization and oxidation.
ChemInform Abstract: A Sustainable Multicomponent Pyrimidine Synthesis.
Authors: Deibl Nicklas , Ament Kevin , Kempe Rhett 
Published: March 2016

AbstractAn Ir‐catalyzed three‐component coupling of a secondary alcohol, a primary alcohol, and an amidine is established to give a variety of tri‐ and tetrasubstituted pyrimidines.
ChemInform Abstract: Pd/C‐Catalyzed Carbonylative C—H Activation with DMF as the CO Source.
Authors: Chen Jianbin , Natte Kishore , Wu Xiao‐Feng 
Published: March 2016

AbstractN‐Arylpyridin‐2‐amines are converted into quinazolinone derivatives in moderate to good yields via carbonylative cyclization.
ChemInform Abstract: Electrophile‐Mediated Reactions of Functionalized Propargylic Substrates.
Authors: Urbanaite Aurelija , Jonusis Mantas , Buksnaitiene Rita , Balkaitis Simonas , Cikotiene Inga 
Published: March 2016

AbstractSubstrates of type (I) having propargyl moieties are found to undergo electrophile‐initiated ring‐closing reactions without the need for any transition‐metal catalyst.
ChemInform Abstract: Multicomponent Cascade Reactions of Unprotected Ketoses and Amino Acids — Access to a Defined Configured Quaternary Stereogenic Center.
Authors: Richter Celin , Nguyen Trung Minh , Mahrwald Rainer 
Published: March 2016

AbstractIn this stereoselective multicomponent cascade reaction of ketoses with amino acids matched/mismatched situations occur.
ChemInform Abstract: Synthesis of Triborylalkenes from Terminal Alkynes by Iridium‐Catalyzed Tandem C—H Borylation and Diboration.
Authors: Lee Chun‐I , Shih Wei‐Chun , Zhou Jia , Reibenspies Joseph H. , Ozerov Oleg V. 
Published: March 2016

AbstractThe two‐step approach for the synthesis of triborylalkenes starts with the conversion of terminal alkynes and pinacolborane (HBpin) into alkynylboronate catalyzed by a SiNN pincer ligand supported iridium complex, followed by treatment of the reaction mixture with CO for the generation of a new catalyst.
ChemInform Abstract: Facile, Catalytic Dehydrocoupling of Phosphines Using β‐Diketiminate Iron(II) Complexes.
Authors: King Andrew K. , Buchard Antoine , Mahon Mary F. , Webster Ruth L. 
Published: March 2016

AbstractThe iron complex DKIF is prepared and successfully applied as catalyst for the dimerization of primary phosphine (I) and secondary phosphines (III) as well as for the hydrophosphination of alkenes (V).
ChemInform Abstract: Structurally Novel C17‐Sesquiterpene Lactones from Ainsliaea pertyoides.
Authors: Shi Zhi‐Ran , Shen Yun‐Heng , Zhang Xian‐Yuan , Fang Xin , Zeng Ren‐Tao , Liu Qing‐Xin , Zhuo Zhi‐Guo , Feng Feng , Zhang Wei‐Dong 
Published: March 2016

AbstractPertyolides A (I) and B (II) are isolated together with fifteen known sesquiterpene lactones.
ChemInform Abstract: Luakuliides A—C, Cytotoxic Labdane Diterpenes from a Tongan Dictyoceratid Sponge.
Authors: Barber Jacqueline M. , Leahy Dora C. , Miller John H. , Northcote Peter T. 
Published: March 2016

Abstractisolation and structure elucidation of luakuliide A (Ia) and its methyl acetal (Ib), luakuliides B (II), and C (III)
ChemInform Abstract: One‐Pot Synthesis of Hydrophobically Modified Iminosugar C‐Alkynylglycosides: Facile Synthesis of Polyhydroxy Tetrahydroindolizines.
Authors: Senthilkumar Soundararasu , Prasad Sure Siva , Das Amrita , Baskaran Sundarababu 
Published: March 2016

AbstractThe reaction of D‐ribose tosylate (I) with allyl amine followed by a Cu‐catalyzed reaction with terminal alkynes (III) gives rise to new iminosugar β‐C‐alkynylglycosides (IV), which are readily converted into novel 1‐vinyl‐tetrahydroindolizine DNA‐cross‐linking agents (V).
ChemInform Abstract: Synthetic Studies on Indolocarbazoles: A Facile Synthesis of Staurosporinone Analogues.
Authors: Raju Potharaju , Gobi Rajeshwaran Ganesan , Mohanakrishnan Arasambattu K. 
Published: March 2016

AbstractAn efficient multi‐step route for the synthesis of staurosporin aglycon analogues (I) is developed starting from commercially available 2‐methylindole.
ChemInform Abstract: Novel Cytotoxic Isobenzofuran Derivatives from Streptomyces sp. IFM 11490.
Authors: Yixizhuoma Yixizhuoma , Tsukahara Kentaro , Toume Kazufumi , Ishikawa Naoki , Abdelfattah Mohamed S. , Ishibashi Masami 
Published: March 2016

Abstractisolation and structure elucidation of elmonin (I), elmenol A (II), and B (III)
ChemInform Abstract: Potential and Challenges of Zeolite Chemistry in the Catalytic Conversion of Biomass
Authors: Ennaert Thijs , Van Aelst Joost , Dijkmans Jan , De Clercq Rik , Schutyser Wouter , Dusselier Michiel , Verboekend Danny , Sels Bert F. 
Published: March 2016

AbstractReview: 421 refs.
Development of deformable connection for earthquake‐resistant buildings to reduce floor accelerations and force responses
Authors: Tsampras Georgios , Sause Richard , Zhang Dichuan , Fleischman Robert B. , Restrepo Jose I. , Mar David , Maffei Joseph 
Published: March 2016

SummaryThis paper presents the development of a deformable connection that is used to connect each floor system of the flexible gravity load resisting system (GLRS) with the stiff lateral force resisting system (LFRS) of an earthquake‐resistant building. It is shown that the deformable connection acts as a seismic response modification device, which limits the lateral forces transferred from each floor to the LFRS and allows relative motion between the GLRS and LFRS. In addition, the floor accelerations and the LFRS story shears related to the higher‐mode responses are reduced. The dispersion of peak responses is also significantly reduced. Numerical simulations of the earthquake response of a 12‐story reinforced concrete shear wall example building with deformable connections are used to define an approximate feasible design space for the deformable connection. The responses of the example building model with deformable connections and the example building model with rigid‐elastic connections are compared. Two configurations of the deformable connection are studied. In one configuration, a buckling restrained brace is used as the limited‐strength load‐carrying hysteretic component of the deformable connection, and in the other configuration, a friction device is used. Low damping laminated rubber bearings are used in both configurations to ensure the out‐of‐plane stability of the LFRS and to provide post‐elastic stiffness to the deformable connection. Important experimental results from full‐scale tests of the deformable connections are presented and used to calibrate numerical models of the connections. Copyright © 2016 John Wiley & Sons, Ltd.
A Comparison of the Forecasting Ability of Immediate Price Impact Models
Authors: Pham Manh Cuong , Duong Huu Nhan , Lajbcygier Paul 
Published: March 2016

AbstractAs a consequence of recent technological advances and the proliferation of algorithmic and high‐frequency trading, the cost of trading in financial markets has irrevocably changed. One important change, known as price impact, relates to how trading affects prices. Price impact represents the largest cost associated with trading. Forecasting price impact is very important as it can provide estimates of trading profits after costs and also suggest optimal execution strategies. Although several models have recently been developed which may forecast the immediate price impact of individual trades, limited work has been done to compare their relative performance. We provide a comprehensive performance evaluation of these models and test for statistically significant outperformance amongst candidate models using out‐of‐sample forecasts. We find that normalizing price impact by its average value significantly enhances the performance of traditional non‐normalized models as the normalization factor captures some of the dynamics of price impact. Copyright © 2016 John Wiley & Sons, Ltd.
Estimation of Market Information Shares: A Comparison
Authors: Lien Donald , Wang Zijun 
Published: March 2016

AbstractThis note investigates via Monte Carlo simulation the finite‐sample performance of two identification schemes that provide unique measures of Hasbrouck‐type information share in price discovery. The Lien and Shrestha (2009) method is based on factorization of the full correlation matrix and the Grammig and Peter (2013) method is based on different correlations of price innovations in the tails and in the center of the distributions. We find that the GP method performs poorly under the chosen data generation processes. The LS method provides at most marginal improvement over the method based upon the upper/lower bound midpoint of the Hasbrouck measure. The results, therefore, support the common practice of the midpoint approach. © 2016 Wiley Periodicals, Inc. Jrl Fut Mark 36:1108–1124, 2016
Synthesis of Multisubstituted Silyloxy‐based Donor‐Acceptor Cyclobutanes by an Acid‐Catalyzed [2+2] Cycloaddition
Authors: Takasu Kiyosei 
Published: March 2016

AbstractThis account summarizes our recent efforts on the acid‐catalyzed [2+2] cycloaddition of silyl enol ethers with α,β‐unsaturated esters, giving donor‐acceptor (D‐A) cyclobutanes and their related reactions. The cycloaddition generally produces multisubstituted cyclobutanes in good yields with high diastereoselectivity. We found that aluminum Lewis acids and triflic imide (Tf2NH) had good catalytic activity. The retro [2+2] cycloaddition proceeded at higher reaction temperatures, and in some cases, diastereoselectivity switching of cycloadducts was observed. A microflow protocol was established for Tf2NH‐catalyzed [2+2] cycloaddition. Although the cycloaddition usually requires cryogenic conditions in a batch reactor, the microreactor system enabled the production of D‐A cyclobutanes, even at ambient temperature. [2+2] Cycloaddition of allylsilanes and alkyl enol ethers, instead of silyl enol ethers, afforded the corresponding D‐A cyclobutanes.
Defining the possible therapeutic benefit of lymphadenectomy among patients undergoing hepatic resection for intrahepatic cholangiocarcinoma
Authors: Vitale Alessandro , Moustafa Mohamed , Spolverato Gaya , Gani Faiz , Cillo Umberto , Pawlik Timothy M. 
Published: March 2016

BackgroundThe aim of the study was to investigate the therapeutic role of lymphadenectomy (LND) in patients with intrahepatic cholangiocarcinoma.Methods826 patients who underwent liver resection were identified using the SEER database from 1988 to 2011. Two groups of patients were defined: 201 (24%) undergoing potentially therapeutic LND (group A, >3 lymph nodes (LN) removed), and 625 (76%) not receiving therapeutic LND (group B, ≤3 LNs removed). A propensity score analysis was performed to create a matched cohort of 402 patients (201 in either group). The survival benefit of therapeutic LND was also estimated using multivariate parametric analysis comparing two simulated cohorts of 826 patients.Results1‐, 3‐, and 5‐year survival rates were 71%, 37%, and 27% for group A patients, and 73%, 37%, and 27% for matched group B patients (P = 0.656). When simulation analysis was performed, a moderate survival benefit of LND of 5.46 months was calculated (95%CI, 4.64–6.29). Considerable differences in LND survival benefit predictions were found according to patient's sex (males, 9.90 vs. females 1.16 months), age (≤60 years, 15 vs. >60 years, −1.34 months), and tumor size (>50 mm, 9.20 vs. ≤50 mm, −0.28).ConclusionsLND therapeutic benefit among a subset of patients. Future work is required to investigate the role of routine LND among these patients. J. Surg. Oncol. 2016;113:685–691. © 2016 Wiley Periodicals, Inc.