bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benchmark the best factory data collection system (FDC) using AHP-GRA method
Authors: Gangurde Sanjaykumar R 
Published: February 2016

Purpose
– The purpose of this paper is to propose a multi-criteria decision making method to evaluate factory data collection (FDC) system alternatives.

Design/methodology/approach
– “Information” in is fundamental resource to the success of any business which is as valuable as capital or people. The factory data (information) collection system (FDC system) consists of the various paper documents, terminals, and automated devices located throughout the plant for collecting data on shop floor operations for compiling and processing the data. In this paper, nine alternatives of FDC methods are evaluated on the basis of eight criteria. The weight of each criterion is determined using Analytic Hierarchy Process, and the same weights are used to evaluate alternatives of FDC system using Grey Relational Analysis – A multi-criterion decision making method.

Findings
– The methodology facilitates the selection of the best FDC system that will minimize the data entry time and chances of errors. The methodology suggests Radio-Frequency Identification (RFID) system is the most preferred choice (ideal) among the nine alternatives whereas Operation tear strips is the worst solution.

Originality/value
– The proposed methodology will provide a useful tool to the decision maker, which may help to eliminate the associated risks during data entry. The selected best FDC system, i.e. RFID is most suitable tool for ERP system to integrate internal (manufacturing) and external (sales and service) management information system.
Role of green policy on sustainable supply chain management
Authors: Bhardwaj Broto Rauth 
Published: February 2016

Purpose– Green supply chain management (GSCM) has become the driver of sustainable strategy. This topic has been gaining increasing attention within both academia and industry for making the industry competitive. With the ever increasing demand for reducing carbon foot prints and greenhouse gas emission, there is a need to study the various parameters and drivers of sustainable development, especially in supply chain management. The need for developing the sustainable model including the drivers of sustainability needs to be designed. The paper aims to discuss these issues.Design/methodology/approach– Using resource-based theory and value chain analysis; the authors have developed a model for sustainable strategy. The data were collected and analyzed to find the key drivers of sustainability. The data were analyzed with the help of regression and correlation analysis.Findings– After providing a background discussion on GSCM, the authors categorize and review recent GSCM literature under three broad categories, with a special emphasis on investigation of adoption, diffusion, and outcomes of GSCM practices. Within this review framework, the authors also identified GSCM research questions that are worthy of investigation. The study suggests that the main drivers of GSCM include the environmental policy and the green human resource management by providing them training for adopting sustainability practices. Besides this, another key driver is the sustainability criteria in supplier selection which was found to be enhancing the outcomes of sustainability.Research limitations/implications– The model suggests that we need to have management support for implementing the sustainability strategy in the organization.Practical implications– The study guides the managers for implementing sustainable supply chain management practices in the organization.Social implications– The model including the environment policy (adoption), green human resource management (diffusion), green technology (diffusion), and GSCM.Originality/value– Additional organizational theories which are considered valuable for future GSCM research are also identified with a conclusion for this review.
Meta modelling of job satisfaction effective factors for improvement policy making in organizations
Authors: Fazlollahtabar Hamed , Mahdavi Iraj , Mahdavi-Amiri Nezam 
Published: February 2016

Purpose
– The purpose of this paper is to propose a Meta modeling based on regression, neural network, and clustering to analyze the job satisfaction factors and improvement policy making.

Design/methodology/approach
– Since any job satisfaction evaluation supposes to improve the status by prescribing specific strategies to be performed in the organization, proposing applicable strategies is decisively important. Task demand, social structure and leader-member exchange (LMX) are general applications easily conceptualized while proposing job satisfaction improvement strategies.

Findings
– On the basis of these empirical findings, the authors first aim to identify relationships between LMX, task demand, social structure and individual factors, organizational factors, job properties, which are easier to be employed in strategy formulation for job satisfaction, and then determine the sub-factors and subsequently cluster them. The effectiveness of the proposed model is verified by a case study.

Originality/value
– Here, a Meta modeling based on regression, neural network, and clustering is proposed to analyze the job satisfaction factors and improvement policy making.
Distinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant Tissue
Authors: Dezzutti Charlene S. , Else Laura J. , Yandura Sarah E. , Shetler Cory , Russo Julie , Back David J. , McGowan Ian 
Published: February 2016

ABSTRACT

A long-acting injectable form of rilpivirine (RPV) is being evaluated in clinical trials for the prevention of HIV infection. Preclinical testing was undertaken to define RPV pharmacokinetic (PK) and pharmacodynamic (PD) activities in ectocervical and colonic tissue treated
in vitro
. Tenfold dilutions of RPV were added to the basolateral medium of polarized ectocervical and colonic explant tissues. To half the explants, HIV-1
BaL
was applied to the apical tissue surface. After culture overnight, all the explants were washed and the RPV in the explants not exposed to HIV was quantified using a validated liquid chromatography-mass spectrometry assay. For efficacy, explants exposed to HIV remained in culture, and supernatants were collected to assess viral replication using a p24 enzyme-linked immunosorbent assay. The data were log
10
transformed, and PK/PD correlations were determined using GraphPad Prism and SigmaPlot software. The application of RPV to the basolateral medium at 10 μM and 1 μM was effective in protecting ectocervical and colonic tissues, respectively, from HIV infection. When the RPV in paired ectocervical and colonic explant tissues was quantified, significant inverse linear correlations (
P
< 0.001) between p24 and RPV concentrations were obtained; more viral replication was noted at lower drug levels. Using a maximum effect model, RPV concentrations of 271 nM in ectocervical tissue and 45 nM in colonic tissue were needed to achieve a 90% effective concentration (EC
90
). These data demonstrate that RPV can suppress HIV infection in mucosal tissue but that higher levels of RPV are needed in female genital tract tissue than in gastrointestinal tract tissue for protection.
Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections
Authors: Goutelle Sylvain , Roux Sandrine , Gagnieu Marie-Claude , Valour Florent , Lustig Sébastien , Ader Florence , Laurent Frédéric , Chidiac Christian , Ferry Tristan 
Published: February 2016

ABSTRACT
The interindividual and intraindividual variabilities in daptomycin pharmacokinetics were investigated in 23 patients (69 pharmacokinetic profiles) who were treated for several months for bone and joint infections. Population daptomycin clearance was significantly influenced by renal function and was significantly higher in male than in female patients. We observed significant intraindividual changes in daptomycin clearance, which were uncorrelated with changes in renal function, suggesting that therapeutic drug monitoring is important in patients receiving prolonged daptomycin therapy.
A Flow Cytometry Method for Rapidly Assessing Mycobacterium tuberculosis Responses to Antibiotics with Different Modes of Action
Authors: Hendon-Dunn Charlotte Louise , Doris Kathryn Sarah , Thomas Stephen Richard , Allnutt Jonathan Charles , Marriott Alice Ann Neville , Hatch Kim Alexandra , Watson Robert James , Bottley Graham , Marsh Philip David , Taylor Stephen Charles , Bacon Joanna 
Published: February 2016

ABSTRACT

Current methods for assessing the drug susceptibility of
Mycobacterium tuberculosis
are lengthy and do not capture information about viable organisms that are not immediately culturable under standard laboratory conditions as a result of antibiotic exposure. We have developed a rapid dual-fluorescence flow cytometry method using markers for cell viability and death. We show that the fluorescent marker calcein violet with an acetoxy-methyl ester group (CV-AM) can differentiate between populations of
M. tuberculosis
growing at different rates, while Sytox green (SG) can differentiate between live and dead mycobacteria.
M. tuberculosis
was exposed to isoniazid or rifampin at different concentrations over time and either dual stained with CV-AM and SG and analyzed by flow cytometry or plated to determine the viability of the cells. Although similar trends in the loss of viability were observed when the results of flow cytometry and the plate counting methods were compared, there was a lack of correlation between these two approaches, as the flow cytometry analysis potentially captured information about cell populations that were unable to grow under standard conditions. The flow cytometry approach had an additional advantage in that it could provide insights into the mode of action of the drug: antibiotics targeting the cell wall gave a flow cytometry profile distinct from those inhibiting intracellular processes. This rapid drug susceptibility testing method could identify more effective antimycobacterials, provide information about their potential mode of action, and accelerate their progress to the clinic.
Two Unrelated 8-Vinyl Reductases Ensure Production of Mature Chlorophylls in Acaryochloris marina
Authors: Chen Guangyu E. , Hitchcock Andrew , Jackson Philip J. , Chaudhuri Roy R. , Dickman Mark J. , Hunter C. Neil , Canniffe Daniel P. 
Published: February 2016

ABSTRACT

The major photopigment of the cyanobacterium
Acaryochloris marina
is chlorophyll
d
, while its direct biosynthetic precursor, chlorophyll
a
, is also present in the cell. These pigments, along with the majority of chlorophylls utilized by oxygenic phototrophs, carry an ethyl group at the C-8 position of the molecule, having undergone reduction of a vinyl group during biosynthesis. Two unrelated classes of 8-vinyl reductase involved in the biosynthesis of chlorophylls are known to exist, BciA and BciB. The genome of
Acaryochloris marina
contains open reading frames (ORFs) encoding proteins displaying high sequence similarity to BciA or BciB, although they are annotated as genes involved in transcriptional control (
nmrA
) and methanogenesis (
frhB
), respectively. These genes were introduced into an 8-vinyl chlorophyll
a
-producing Δ
bciB
strain of
Synechocystis
sp. strain PCC 6803, and both were shown to restore synthesis of the pigment with an ethyl group at C-8, demonstrating their activities as 8-vinyl reductases. We propose that
nmrA
and
frhB
be reassigned as
bciA
and
bciB
, respectively; transcript and proteomic analysis of
Acaryochloris marina
reveal that both
bciA
and
bciB
are expressed and their encoded proteins are present in the cell, possibly in order to ensure that all synthesized chlorophyll pigment carries an ethyl group at C-8. Potential reasons for the presence of two 8-vinyl reductases in this strain, which is unique for cyanobacteria, are discussed.

IMPORTANCE
The cyanobacterium
Acaryochloris marina
is the best-studied phototrophic organism that uses chlorophyll
d
for photosynthesis. Unique among cyanobacteria sequenced to date, its genome contains ORFs encoding two unrelated enzymes that catalyze the reduction of the C-8 vinyl group of a precursor molecule to an ethyl group. Carrying a reduced C-8 group may be of particular importance to organisms containing chlorophyll
d
. Plant genomes also contain orthologs of both of these genes; thus, the bacterial progenitor of the chloroplast may also have contained both
bciA
and
bciB
.
Comparison of outcome and interventional complication rate in patients with acute stroke treated with mechanical thrombectomy with and without bridging thrombolysis
Authors: Weber Ralph , Nordmeyer Hannes , Hadisurya Jeffrie , Heddier Markus , Stauder Michael , Stracke Paul , Berger Klaus , Chapot Rene 
Published: February 2016

BackgroundNo randomized trial has investigated the effect of mechanical thrombectomy (MT) alone in patients with acute stroke. There are conflicting results as to whether prior intravenous thrombolysis (IVT) facilitates subsequent MT, and data in patients treated with MT alone owing to contraindications to IVT are limited.ObjectiveTo compare consecutive patients treated with MT alone or with preceding IVT in a large tertiary neurointerventional center, with special emphasis on contraindications to IVT.MethodsRetrospective analysis of 283 consecutive patients with acute ischemic stroke treated with MT in a tertiary neurovascular center over 14 months. Data on characteristics of periprocedural times, recanalization rate, complications, and long-term functional outcome were collected prospectively.ResultsInformation on prior IVT and functional outcome was available in 250 patients. Mean (SD) follow-up period was 5.7 (5.1) months and 105 (42%) patients received both IVT and MT. No significant differences were found in successful recanalization rates (Thrombolysis in Cerebral Infarction (TICI) 2b/3, 73.8% vs 73.1, p=0.952), complication rates, and long-term favorable outcome (modified Rankin Scale 0–2, 35.2% vs 40%, p=0.444) between patients receiving MT plus IVT and those receiving MT alone. A favorable outcome in patients directly treated with MT alone who were eligible for IVT was achieved in 48.2%. Thrombectomy was safe and resulted in a favorable outcome in 32% of patients with absolute contraindications to IVT.ConclusionsPreceding use of IVT was not an independent predictor of favorable outcome in patients with acute stroke treated with MT and complication rates did not differ whether or not IVT was used. MT is safe and achieved a favorable outcome in one-third of patients with stroke ineligible for IVT.
Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders
Authors: Mielke Michelle M. , Milic Natasa M. , Weissgerber Tracey L. , White Wendy M. , Kantarci Kejal , Mosley Thomas H. , Windham B. Gwen , Simpson Brittany N. , Turner Stephen T. , Garovic Vesna D. 
Published: February 2016

Background—
Hypertensive pregnancy disorders have been associated with subjective cognitive complaints or brain white-matter lesions 5 to 10 years after the hypertensive pregnancy. The long-term effects of hypertensive pregnancies on brain structure and cognitive function remain unknown.

Methods and Results—

This study included 1279 women who participated in the Family Blood Pressure Project Genetic Epidemiology Network of Arteriopathy (GENOA) study. As part of the ancillary Genetics of Microangiopathic Brain Injury (GMBI) study, a neurocognitive battery was administered; 1075 also had a brain magnetic resonance imaging. A history of a hypertensive pregnancy disorder was obtained by a self-report using a validated questionnaire. Linear models fit with generalized estimating equations were used to assess the association between hypertensive pregnancy disorders and cognition, adjusting for age, race, education, body mass index, smoking, current hypertension, hypertension duration, and family history of hypertension. Regression models for the brain magnetic resonance imaging outcomes also were adjusted for total intracranial volume. Women with histories of hypertensive pregnancy disorders performed worse on all measures of processing speed (Digital Symbol Substitution Test [mean score, 41.2 versus 43.4;
P
=0.005], Trail Making Test Part A [mean seconds, 45.1 versus 42.2;
P
=0.035], and Stroop [mean score, 173.9 versus 181.0;
P
=0.002]) and had smaller brain volumes compared with women with histories of normotensive pregnancies (286 versus 297;
P
=0.023).

Conclusions—
Hypertensive pregnancy disorders are associated with worse performance on tests of processing speed and smaller brain volumes decades later. Population-based studies are needed to provide critical insight as to the contribution of hypertensive pregnancies to risk of cognitive decline and dementia.
Parity and Components of the Metabolic Syndrome Among US Hispanic/Latina Women
Authors: Vladutiu Catherine J. , Siega-Riz Anna Maria , Sotres-Alvarez Daniela , Stuebe Alison M. , Ni Andy , Tabb Karen M. , Gallo Linda C. , Potter JoNell E. , Heiss Gerardo 
Published: February 2016

Background—
Physiological adaptations occurring across successive pregnancies may increase the risk of adverse cardiovascular health outcomes in later life.

Methods and Results—
The association between parity and metabolic syndrome was examined among 7467 Hispanic/Latina women of diverse backgrounds, aged 18 to 74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) from 2008 to 2011. Metabolic syndrome components were defined according to American Heart Association/National Heart, Lung, and Blood Institute criteria and included abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose. Logistic regression models estimated odds ratios (ORs) adjusting for sociodemographic, behavioral, and reproductive characteristics. At HCHS/SOL baseline, women reported none (21.1%), 1 (19.9%), 2 (25.7%), 3 (18.6%), 4 (8.8%), and ≥5 (5.9%) live births. When compared with women with 1 birth, those with 4 births had the highest odds of abdominal obesity (OR, 2.0; 95% confidence interval, 1.5–2.8) and overall metabolic syndrome (OR, 1.4; 95% confidence interval, 1.0–2.0) and those with ≥5 births had the highest odds of low high-density lipoprotein cholesterol (OR, 1.5; 95% confidence interval, 1.2–2.0) and elevated fasting glucose (OR, 1.6; 95% confidence interval, 1.1–2.4), after adjusting for age, background, education, marital status, income, nativity, smoking, physical activity, menopause, oral contraceptive use, hormone therapy, and field center. Further adjustment for percent body fat attenuated these associations. No associations were observed between parity and elevated triglycerides or high blood pressure.

Conclusions—
Higher parity is associated with an increased prevalence of selected components of the metabolic syndrome among Hispanic/Latina women in the US. High parity among Hispanics/Latinas with a high prevalence of abdominal obesity suggests high risk for metabolic dysregulation.
Field Synopsis of Sex in Clinical Prediction Models for Cardiovascular Disease
Authors: Paulus Jessica K. , Wessler Benjamin S. , Lundquist Christine , Lai Lana L.Y. , Raman Gowri , Lutz Jennifer S. , Kent David M. 
Published: February 2016

Background—
Several widely used risk scores for cardiovascular disease (CVD) incorporate sex effects, yet there has been no systematic summary of the role of sex in clinical prediction models (CPMs). To better understand the potential of these models to support sex-specific care, we conducted a field synopsis of sex effects in CPMs for CVD.

Methods and Results—
We identified CPMs in the Tufts Predictive Analytics and Comparative Effectiveness CPM Registry, a comprehensive database of CVD CPMs published from January 1990 to May 2012. We report the proportion of models including sex effects on CVD incidence or prognosis, summarize the directionality of the predictive effects of sex, and explore factors influencing the inclusion of sex. Of 592 CVD-related CPMs, 193 (33%) included sex as a predictor or presented sex-stratified models. Sex effects were included in 78% (53/68) of models predicting incidence of CVD in a general population, versus only 35% (59/171), 21% (12/58), and 17% (12/72) of models predicting outcomes in patients with coronary artery disease, stroke, and heart failure, respectively. Among sex-including CPMs, women with heart failure were at lower mortality risk in 8 of 8 models; women undergoing revascularization for coronary artery disease were at higher mortality risk in 10 of 12 models. Factors associated with the inclusion of sex effects included the number of outcome events and using cohorts at-risk for CVD (rather than with established CVD).

Conclusions—
Although CPMs hold promise for supporting sex-specific decision making in CVD clinical care, sex effects are included in only one third of published CPMs.
Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study
Authors: Hoffmann Udo , Massaro Joseph M. , D'Agostino Ralph B. , Kathiresan Sekar , Fox Caroline S. , O'Donnell Christopher J. 
Published: February 2016

Background

We determined whether vascular and valvular calcification predicted incident major coronary heart disease, cardiovascular disease (
CVD
), and all‐cause mortality independent of Framingham risk factors in the community‐based Framingham Heart Study.

Methods and Results

Coronary artery calcium (
CAC
), thoracic and abdominal aortic calcium, and mitral or aortic valve calcium were measured by cardiac computed tomography in participants free of
CVD
. Participants were followed for a median of 8 years. Multivariate Cox proportional hazards models were used to determine association of
CAC
, thoracic and abdominal aortic calcium, and mitral and aortic valve calcium with end points. Improvement in discrimination beyond risk factors was tested via the C‐statistic and net reclassification index. In this cohort of 3486 participants (mean age 50±10 years; 51% female),
CAC
was most strongly associated with major coronary heart disease, followed by major
CVD
, and all‐cause mortality independent of Framingham risk factors. Among noncoronary calcifications, mitral valve calcium was associated with major
CVD
and all‐cause mortality independent of Framingham risk factors and
CAC
.
CAC
significantly improved discriminatory value beyond risk factors for coronary heart disease (area under the curve 0.78–0.82; net reclassification index 32%, 95%
CI
11–53) but not for
CVD
.
CAC
accurately reclassified 85% of the 261 patients who were at intermediate (5–10%) 10‐year risk for coronary heart disease based on Framingham risk factors to either low risk (n=172; no events observed) or high risk (n=53; observed event rate 8%).

Conclusions

CAC
improves discrimination and risk reclassification for major coronary heart disease and
CVD
beyond risk factors in asymptomatic community‐dwelling persons and accurately reclassifies two‐thirds of the intermediate‐risk population.