bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high step‐up single switch DC‐DC quadratic boost converter based on coupled inductor with reduced voltage stress of power components
Authors: Modaberi Seyyed Alireza , Bolandi Tohid Ghanizadeh , Hassanifar Mahyar , Neyshabouri Yousef 
Published: September 2024

AbstractThis paper introduces a coupled inductor (CI)‐based high step‐up DC‐DC converter. Cascaded or quadratic DC–DC converters are the most practical solution to achieve a wide conversion ratio and reduced current ripple. The proposed structure (P1) is achieved by a combination of a base structure of two‐stage boost converter with one active switch, a CI, and a voltage multiplier cell (VMC). The secondary side of the CI is placed at the output side, where it is combined with a VMC. In the proposed topology, a passive clamp consisting of a diode and a capacitor is added to minimize the voltage stress on the active switch. In addition, the passive clamp recycles the leakage energy of the CI and causes to increase the efficiency. The input source current ripple is low, and the input current is continuous, which are very suitable for renewable energy applications. Additionally, the voltage stresses on switches are less than some quadratic DC‐DC boost converters that have been presented. Also, an extended topology of P1 is proposed as the second proposed converter (P2), to enhance the operation of P1. Moreover, to show the feasibility and performance of the presented converter, a laboratory prototype circuit is examined. The results accredit the theoretical analysis and experimental outcomes of the presented converter.
Halogenated Adenine and Adenosine Natural Products in Streptomyces sp. JCM9888
Authors: Chen Yawen , Lowe Phillip T. , Deng Hai , O'Hagan David 
Published: September 2024

AbstractAscamycin 1 and dealanylascamycin 2 are adenosine containing nucleoside antibiotics carrying the rare 5’‐O‐sulfamoyl ribose motif and a chlorine atom attached to C2 of the adenine ring. Gene knockouts (ΔacmK and ΔacmJ) in the producing strain, Streptomyces sp. JCM9888, generated mutants that were disabled in the assembly of the sulfamoyl moiety. This resulted in the production of 2‐chloroadenosine 3 and 2‐chloroadenine 4, indicating that purine halogenation can occur independently of sulfamoylation. Incubations in media enriched in bromide content resulted also in the identification of 2‐bromoadenine 5, 2‐bromoadenosine 6 and 5′‐O‐sulfamoyl‐2‐bromoadenosine 7.
Optimizing the performance of solar evacuated tube collector systems for seawater desalination
Authors: Patel Nitesh , Joshi Unnati , Patel Vijay , Joshi Anand , Oza Ankit D. , Kumar Abhinav , Velkin Vladimir Ivanovich 
Published: September 2024

AbstractSolar thermal collectors, such as evacuated tube collectors (ETCs), are essential for harnessing renewable energy, yet their efficiency is often hindered by thermal losses and limited heat transfer. This study focuses on enhancing ETC performance for seawater desalination by using nanofluids as heat transfer fluids. These modifications aim to improve heat transfer rates, reduce thermal losses, increase the maximum temperature attainable, and minimize the collector area required. An experimental setup has been developed at Parul University in Vadodara, Gujarat, India. Key parameters such as air mass flow rate, inclination angle, water mass flow rate, nanofluid volume percentage, and screw conveyor speed were optimized to achieve ideal temperature levels. Results indicate that the optimal configuration for steam generation includes a high air mass flow rate and a 40° inclination angle for the ETC. Additionally, a water mass flow rate of 10 LPH and a screw conveyor speed of 30 rpm are crucial for optimal performance. Data collected showed the highest solar energy levels between 12 PM and 1 PM, which significant decreases post this peak period. These findings highlight the potential of nanomaterial‐based enhancements in improving the efficiency and cost‐effectiveness of solar thermal systems for renewable energy applications.
Quality of life and cannabis use among patients with drug‐resistant epilepsy—An observational study from a Canadian tertiary care referral center
Authors: Jhanji Kanika , Shivji Zaitoon , Lazaj Marion , Lomax Lysa Boisse , Winston Gavin P. , Shukla Garima 
Published: September 2024

AbstractObjectiveVery few publications have reported the impact of artisanal cannabis use on overall quality of life among people with drug‐resistant epilepsy. This study aimed to evaluate the association of artisanal cannabis use among adults with drug‐resistant epilepsy with quality of life, and to determine if an association exists between Quality‐of‐Life in Epilepsy Inventory‐31 (QOLIE‐31) ‘T scores’ and different clinical variables.MethodsThis study included patients admitted to a Canadian tertiary care epilepsy center as part of a larger study. These patients were confirmed to have drug‐resistant epilepsy by an epileptologist at the Ambulatory Epilepsy Clinic. Patients were categorized into cannabis users (CAN group) (n = 25) and Non‐cannabis users (Non‐CAN group) (n = 21). Data was collected on RedCap® for epilepsy and cannabis use details. These were analyzed for an association using a binary multivariable logistic regression model between QOLIE‐31 ‘T scores’ and age, sex, epilepsy duration, age at initiation of use, duration of cannabis use and psychiatric related comorbidity for all patients. Additionally, different ‘T subscores’ of the questionnaire were compared between the CAN group and Non‐CAN group.ResultsA statistically significant difference between the CAN group and Non‐CAN group for the T subscore ‘energy and fatigue’ (p = .004) was found, with the CAN group scoring higher. However, for the ‘overall T score’ between the two groups there was no statically significant difference (p = .11). Additionally, a significant negative correlation between ‘overall T score’ and cannabis use disorder (p = .032) was found.SignificanceThis study provides new data on association of quality of life in epilepsy with cannabis use and can serve as a foundation for larger future studies to better assess this association.
Development and validation of a metacognitive assessment tool for Turkish preschool children: A test for 48–66 months‐old
Authors: İmir Hatice Merve , Kaynak‐Ekici K. Büşra , Temel Z. Fulya 
Published: September 2024

AbstractThis study examines metacognitive monitoring in Turkish preschoolers aged 48–66 months, crucial for their learning and development. A specialised paired‐association task was designed to assess higher‐order thinking skills in this age group. Data from 160 children (52.5% girls, 47.5% boys; mean age 57.6 months, standard deviation 4.8) were analysed. The Metacognitive Thinking Test includes Recall and Judgement sections, where children rate confidence after recall attempts. Factor analysis of the Judgement Part revealed a two‐factor structure with 14 items demonstrating memory‐confidence alignment. The overall test's Cronbach's alpha value is 0.820. Notably, children tended to overestimate inaccurate recollections, aligning with the Dunning–Kruger effect. Despite limitations, the study sheds light on the complex relationship between confidence and accuracy in young children's metacognitive monitoring development, laying the foundation for further research in this area.
Caregiver executive functions are associated with infant visual working memory
Authors: Amaireh Ghada , Caes Line , Theyer Aimee , Davidson Christina , Wijeakumar Sobanawartiny 
Published: September 2024

AbstractCaregiver executive functions (EFs) play an integral role in shaping cognitive development. Here, we investigated how caregiver EF abilities (86 caregivers; mean age = 33.4 years, SD = 4.5) was associated with visual working memory (VWM) in infants (86 infants females; mean age = 250.6 days, SD = 35.8). The BRIEF‐A was used to assess caregiver EFs, and a preferential looking task along with fNIRS was used to assess VWM function in infants. Our findings revealed that better caregiver behavioral regulation was associated with better VWM performance, greater right‐lateralized parietal activation, and left‐lateralized frontal suppression, while better caregiver metacognition and emotional control was associated with greater right‐lateralized temporal suppression in infants. Taken together, these associations suggest that better caregiver EF abilities might shape visuo‐spatial attention and memory, guide fixation on task‐relevant goals, and suppress distractions in children from as early as the first year of life.Highlights

The study investigated the association between caregiver executive functions (EF) and visual working memory (VWM) function in infants.
Caregiver EFs were assessed using the BRIEF‐A questionnaire, and infant VWM function was assessed using the preferential‐looking task and brain imaging.
Better caregiver EF abilities were associated with better VWM behavior and fronto‐temporo‐parietal engagement in infants.
Study of evapotranspiration and crop coefficients for eggplant in a Venlo‐type greenhouse in South China
Authors: Wang Biyu , Bao Rongxuan , Yan Haofang , Zheng Hexiang , Wu Jiabin , Zhang Chuan , Wang Guoqing 
Published: September 2024

AbstractDetermination of greenhouse evapotranspiration (ETc) and the response mechanism of environmental factors are important for accurate irrigation management and greenhouse environmental control. Models for predicting ETc under greenhouse conditions are extremely scarce in comparison to those under open field conditions. Meteorological data inside and outside a Venlo‐type greenhouse were measured from April to July 2015 to estimate the reference evapotranspiration (ET0) based on four approaches (the Penman–Monteith model, a revised Penman–Monteith model, a modified Priestley–Taylor approach and the Irmark–Allen fitting approach). The daily ET0 values inside the greenhouse calculated from these four methods presented similar variation trends but were somewhat different. The ETc for eggplant in the greenhouse was measured by lysimeters to estimate the crop coefficient with the FAO‐56 method (Kc = ETc/ET0), and the response mechanism of environmental factors on the ETc was analysed. The results showed that the crop coefficients of the eggplant were different, with values of 0.94–1.97, 0.83–1.87, 0.64–1.34 and 0.58–1.21 based on the ET0 from the Penman–Monteith model, revised Penman–Monteith model, modified Priestley–Taylor approach and Irmark–Allen fitting approach, respectively; the net radiation showed the highest correlation with the ETc; the secondary parameters were the air temperature and solar radiation, with R2 values equal to 0.77 and 0.75, respectively; and the relative humidity and soil temperature showed different extents of influence on the ETc. The results of this study provide more options for greenhouse cultivars to accurately determine the ETc of eggplants using the FAO‐56 method based on the availability of different meteorological data.
Radiography students' knowledge, attitude and practice relating to infection prevention and control in the use of contrast media injectors in computed tomography
Authors: Abu Awwad Dania , Hill Suzanne , Chau Minh , Lewis Sarah , Jimenez Yobelli Alexandra 
Published: September 2024

AbstractIntroductionRadiography students complete professional placements in various clinical settings and must adhere to distinct infection prevention and control (IPC) protocols. The aim of this study was to explore radiography students' training, knowledge, attitudes, and practice (KAP) relating to IPC in the use of contrast media injectors in computed tomography (CT).MethodsAn online survey study was undertaken with radiography students enrolled at two Australian universities. Survey questions related to contrast media training and KAP regarding IPC in CT. Data was summarised using descriptive statistics, with comparisons between experience in public and private practice. One free‐text response question focused on non‐adherence to IPC best practice, analysed using content analysis.ResultsIn total, 40 students completed the survey (9% response rate). Reports of IPC and contrast media equipment training was high, with disposition for further training. Regarding IPC knowledge, 65% of students responded correctly to all ‘knowledge’ items (individual scores range: 60–100%). Low consensus was observed regarding whether gloves replace the need for hand hygiene and if CT contrast tubing poses risk to healthcare workers (85% each). Mean scores ranged from 41% to 100% regarding identification of sterile syringe and tubing components. Responses to the open‐ended question were categorised into four themes: ‘High non‐adherence risk working conditions’, ‘attitudes and practice’, ‘knowledge’, and ‘prioritise good IPC practice’.ConclusionsRadiography students demonstrate varied comprehension of IPC regarding contrast media equipment, and results suggest need for collaborative efforts between academic institutions and clinical training sites to integrate IPC protocols into curricula and on‐site training.
Methotrexate induced hepatotoxicity in metabolic dysfunction‐associated steatotic liver disease
Authors: Berkemeyer Andrea , Wagner Ellen , Hashmat Shireen , Azzam Ruba K. 
Published: September 2024

AbstractHepatotoxicity is an under‐recognized and potentially fatal side effect of high‐dose methotrexate (HDMTX) chemotherapy, and this risk is compounded in children with metabolic dysfunction‐associated steatotic liver disease and/or metabolic‐associated steatohepatitis. We present the case of a 12‐year‐old obese, Hispanic male with elevated hepatic transaminases of unknown etiology at initiation of high‐risk B‐cell acute lymphoblastic leukemia chemotherapy. He developed acute kidney injury within 24 hours of receiving intravenous HDMTX which progressed to acute hepatic failure. Liver biopsy confirmed methotrexate toxicity aggravated by undiagnosed metabolic dysfunction‐associated steatotic liver disease. Rapid deterioration precluded liver transplantation, and he died 21 days after HDMTX treatment. This case highlights the need for comprehensive hepatic evaluation in patients with known or suspected liver disease when administering HDMTX. Dialysis should be considered if delayed methotrexate clearance occurs due to potential for rapid, irreversible hepatotoxicity.
How Residents' Perceived Justice and Emotional Solidarity Interact With Their Quality of Life and Support for Tourism Development?
Authors: Gautam Vikas , Bhalla Saubhagya 
Published: September 2024

ABSTRACTCurrent study developed and validated an integrated model for examining the relationships among perceived justice, residents' quality of life, emotional solidarity, and support for tourism development. Study's integral model was estimated by using covariance based structural equation modeling with the help of 365 sample data. Procedural justice was discovered as the most reliable indicator of residents' quality of life. Additionally, it was discovered that inhabitants' support for tourism development was most strongly predicted with emotional closeness, followed by welcoming nature, and sympathetic understanding. Results confirmed that locals' support for tourism development is primarily due to procedural justice, which is followed by distributive and interactional justice. Findings also supported the hypothesis that residents' quality of life predicts their support for tourism development. Academic contributions and practical implications of the study are discussed at large.
Exploring Negative Restaurant Experiences Through an Extended Mehrabian‐Russell Model: An Attributional Perspective
Authors: Ülker Pembe , Karamustafa Kurtuluş 
Published: September 2024

ABSTRACTThe study aims to explore the relationships between service failure severity, negative emotions, level of dissatisfaction, switching intention, and the intention to spread negative word‐of‐mouth (nWOM) in the restaurant context. Additionally, it seeks to investigate how customers' perceptions of the controllability and stability of failures moderate these relationships. Employing a quantitative research approach, data collection was conducted through surveys using a convenience sampling method, resulting in 561 valid responses from Turkish customers. The collected data underwent multi‐group structural equation modeling to examine the proposed relationships, revealing that the severity of failure positively impacts negative emotions and dissatisfaction levels, negative emotions influence the intention to spread nWOM, and dissatisfaction levels positively affect switching intention and the intention to spread nWOM. Furthermore, both controllability and stability perceptions play a moderating role between the severity of the failure and negative emotions, thereby confirming the stimulus, organism, and response model to a significant extent.
Robust pricing and inventory decisions in ship‐from‐store omnichannel operations
Authors: Sun Yue , Qiu Ruozhen , Sun Minghe 
Published: September 2024

AbstractThis work studies the deployment of the ship‐from‐store omnichannel strategy and the pricing and inventory decisions for an online retailer. Robust optimization models are constructed for the online‐only and the ship‐from‐store modes under a budgeted uncertainty set. The ARIMA model is used to predict the parameter values of the budgeted uncertainty set using historical demand data. The closed‐form optimal solution for the online‐only mode is obtained. The robust counterpart model for the ship‐from‐store mode is converted to a mixed integer quadratic programming model. Numerical studies are conducted to validate the theoretical results and to verify the effectiveness and practicality of the developed robust optimization solution approach. The results show that adopting a ship‐from‐store strategy may hurt the retailer's profit if a significant proportion of consumers are time‐sensitive with high travel cost. The ship‐from‐store strategy is optimal if it significantly boosts market growth.
Reading between the lines: A study of Harris lines in Middle Holocene foragers of the Cis‐Baikal
Authors: Michelman Lauren M. , Bazaliiskii Vladimir I. , Weber Andrzej W. , Lieverse Angela R. 
Published: September 2024

AbstractHarris lines (HLs) are radiographically visible transverse lines of thickened bone that develop from temporary growth cessation during early life. Often attributed to physiological stress during development, HLs are frequently observed in the long bones of adolescents and become less visible over time due to bone remodeling. In recent years, the validity of HL as a sign of stress has been called into question and the methods used in studying HL through X‐ray analysis scrutinized. In this study, 80 individuals from the Middle Holocene Cis‐Baikal region of Siberia, from the Early Neolithic (EN; 7560–6660 HPD cal. BP) and Late Neolithic (LN; 6060–4970 HPD cal. BP), were studied for the presence and severity of HL. Radiographic analysis employed both the traditional clinical anteroposterior (A–P) orientation and a potentially improved mediolateral (M–L) orientation. EN groups in the Cis‐Baikal are known to have experienced higher levels than their LN counterparts; thus, if HL reflect stress experiences, we expected to see more HL in the EN population compared with the LN population. We also expected more visible HL in the M–L orientation due to the suggested improvement in capturing more lines compared with the A–P orientation. While the results support the use of M–L orientation during X‐ray capture of HL, there was not a higher number of HL in the EN population as expected. Instead, no significant differences were found in HL severity between the EN and LN populations, and age‐at‐death resulted in a greater effect on HL counts regardless of mortuary site. The results from this study align not with known stress data from the Middle Holocene Cis‐Baikal populations but rather with data pertaining to known growth patterns. We therefore advocate against the use of HL as a sign of physiological stress and instead suggest HL as a reflection of bone growth trajectory.
Top‐down mass spectrometry analysis of capsid proteins of recombinant adeno‐associated virus using multiple ion activations and proton transfer charge reduction
Authors: Kline Jake T. , Huang Jingjing , Lieu Linda B. , Srzentić Kristina , Bergen David , Mullen Christopher , McAlister Graeme C. , Durbin Kenneth R. , Melani Rafael D. , Fornelli Luca 
Published: September 2024

AbstractAdeno‐associated viruses (AAVs) are common vectors for emerging gene therapies due to their lack of pathogenicity in humans. Here, we present our investigation of the viral proteins (i.e., VP1, VP2, and VP3) of the capsid of AAVs via top‐down mass spectrometry (MS). These proteins, ranging from 59 to 81 kDa, were chromatographically separated using hydrophilic interaction liquid chromatography and characterized in the gas‐phase by high‐resolution Orbitrap Fourier transform MS. Complementary ion dissociation methods were utilized to improve the overall sequence coverage. By reducing the overlap of product ion signals via proton transfer charge reduction on the Orbitrap Ascend BioPharma Tribrid mass spectrometer, the sequence coverage of each VP was significantly increased, reaching up to ∼40% in the case of VP3. These results showcase the improvements in the sequencing of proteins >30 kDa that can be achieved by manipulating product ions via gas‐phase reactions to obtain easy‐to‐interpret fragmentation mass spectra.
TADF‐Guiding Modification of Endoplasmic Reticulum‐Targeted Photosensitizers for Efficient Photodynamic Immunotherapy
Authors: Song Jiaxuan , Fang Hao , Wang Xudong , Zhong Wenda 
Published: September 2024

AbstractPharmacological activation of the immunogenic cell death (ICD) pathway by endoplasmic reticulum (ER) targeted photosensitizer (PS) has become a promising strategy for tumor immunotherapy. Despite a clear demand for ER‐targeted PS, the sluggish intersystem crossing (ISC) process, unstable excited state, insufficient ROS production, and immunosuppressive tumor microenvironment (ITME) combined to cause the high‐efficiency agents are still limited. Herein, three groups commonly used in thermally activated delayed fluorescence (TADF) molecular design are used to modify the excited state characteristics of xanthene‐based cyanine PS (obtained the XCy‐based PS). The electronic and geometric modulation effectively optimize the excited state characteristics, facilitating the ISC process and prolonging the excited state life for boosting ROS generation. Among them, car‐XCy showed 100 times longer excited state life and 225% higher ROS yield than that of original XCy. The satisfactory ROS production and ER‐targeted ability of car‐XCy arouse intense ER stress to activate the ICD. Adequate antigen presentation promotes the dendritic cell maturation and infiltration of cytotoxic T lymphocytes (CTLs), ultimately reversing the ITME to realize efficient immunotherapy. As a result, significant inhibition is observed in both primary and distant tumors, underscoring the efficacy of this TADF‐guiding excited state characteristics modulation strategy for developing photodynamic immunotherapy drugs.