bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mn─O Covalency as a Lever for Na⁺ Intercalation Kinetics: The Role of Oxygen Edge‐Sharing Co Octahedral Sites in MnO₂
Authors: Liu Yuanming , Fu Weijie , Yao Shuyun , Wang Shiyu , Ji Yingjie , Li Jingxian , Shi Lanlan , Wang Xiaojun , Zhang Feike , Yang Jinghua , Liu Ruilong , Xie Jiangzhou , Yang Zhiyu , Yan Yi‐Ming 
Published: September 2024

AbstractThe strategic enhancement of manganese–oxygen (Mn─O) covalency is a promising approach to improve the intercalation kinetics of sodium ions (Na⁺) in manganese dioxide (MnO2). In this study, an augmenting Mn─O covalency in MnO2 by strategically incorporating cobalt at oxygen edge‐sharing Co octahedral sites is focused on. Both experimental results and density functional theory (DFT) calculations reveal an increased electron polarization from oxygen to manganese, surpassing that directed toward cobalt, thereby facilitating enhanced electron transfer and strengthening covalency. The synthesized Co–MnO2 material exhibits outstanding electrochemical performance, demonstrating a superior specific capacitance of 388 F g−1 at 1 A g−1 and maintaining 97.21% capacity retention after 12000 cycles. Additionally, an asymmetric supercapacitor constructed using Co–MnO2 achieved a high energy density of 35 Wh kg−1 at a power density of 1000 W kg−1, underscoring the efficacy of this material in practical applications. This work highlights the critical role of transition metal–oxygen interactions in optimizing electrode materials and introduces a robust approach to enhance the functional properties of manganese oxides, thereby advancing high‐performance energy storage technologies.
Functionalized sp2 Carbon‐Conjugated Covalent Organic Frameworks for Interfacial Modulation of Inverted Perovskite Solar Cells
Authors: Abuzeid Hesham R. , Tay Darrell Jun Jie , Febriansyah Benny , Kanwat Anil , Salim Teddy , Zhumekenov Ayan A. , Pullarkat Sumod A. , Mathews Nripan 
Published: September 2024

AbstractInterfacial modulation utilizing functional materials is proven to be crucial for obtaining high photovoltaic performance in lead halide perovskite solar cells (PSCs). This study investigates, for the first time, the utilization of a pyrene‐based sp2 carbon‐conjugated covalent organic framework (sp2c‐COF) as an interfacial layer in inverted PSCs. Functionalized with cyano (–CN) Lewis base groups, the sp2c‐COF exhibits a dual effect, simultaneously passivating both the NiOx and the perovskite layers. Detailed characterization results highlight the role of sp2c‐COF in reducing the Ni3+ defect density in NiOx films and forming Lewis acid‐base adducts with undercoordinated Pb2+ on the perovskite surfaces, thereby inhibiting interfacial redox reactions and suppressing non‐radiative recombination. Moreover, sp2c‐COF leads to improved crystallinity of perovskite films. Benefiting from the synergistic effects, sp2c‐COF‐modified devices delivered a champion efficiency of 17.64%. These findings underscore the potential of sp2c‐COF as a functional interface material for PSCs, offering enhanced efficiency and stability. The study contributes to advancing the understanding and application of covalent organic frameworks in photovoltaic technologies.
Recommendation of consensus definition of sea turtle fibropapillomatosis
Authors: Saladin Claire , Freggi Daniela 
Published: September 2024

AbstractSea turtle fibropapillomatosis (FP) is an emerging transboundary contagious disease that affected concomitantly two different marine hot spots in the Northern Atlantic Ocean and in the South China Sea at the beginning of the twentieth century. FP reached a panzootic status in the 1990s in green turtle (Chelonia mydas) populations, with increased risks of emergence and spread of the disease which have been correlated with climate induced terrestrial and oceanic physical and chemical changes. During 2023–2024, scientific experts performed a bibliographic review and recommend the consensus definition of sea turtle fibropapillomatosis. FP is an emerging transboundary viral terrestrial and aquatic contagious neoplastic syndrome involving cancerous molecular transmission pathways, which may affect all species of sea turtles at all life stages. The diagnosis of the most common verrucous form of FP is pathognomonic by visual examination of a sea turtle. We summarize the main clinical characteristics of FP, moderated by a degree of confidence of research findings adapted from the Intergovernmental Panel on Climate Change (IPCC) assessment reports. We recommend the implementation of a universal and transparent monitoring strategy of sea turtle fibropapillomatosis in sentinel bays, under the governance of the World Organisation for Animal Health.
Effects of Random Feeding Schedule on Pacing in Asiatic Lions (Panthera leo persicus)
Authors: Fitskie Leonie , Kappelhof Jeroen , Cunha Filipe 
Published: September 2024

ABSTRACTFor large felids in the wild, intervals between feeding events are irregular since these depend on prey availability and individual hunting success. In contrast, many zoos feed their large felids on fixed schedules. Predictable feeding schedules could induce food anticipatory behavior, like pacing, and randomizing feeding schedules may reduce this anticipatory behavior. Furthermore, random feeding schedules create more variability in the animals environment, which may reduce frustration or boredom. This case study aimed to investigate the effects of a random feeding schedule on pacing behavior of captive Asiatic lions (Panthera leo persica) in the Rotterdam Zoo, The Netherlands. Study animals were observed directly under two treatments: “fixed feeding” (i.e., two fixed feeding days per week) and “random feeding” (i.e., two semi‐randomly picked feeding days per week). Under the random feeding schedule, the mean pacing proportion of lions significantly decreased compared to the fixed feeding schedule. These findings suggest that a random feeding schedule could reduce pacing, either of anticipatory or stereotypic nature, in Asiatic lions. Random feeding schedules do pose a few logistic challenges, such as zookeeper schedules and transport or storage of feed. Nevertheless, random feeding could be a relatively inexpensive strategy to reduce pacing.
Konservative Therapie der Patellaerstluxation
Authors: Valle C. , Balcarek P. 
Published: September 2024

ZusammenfassungEine Patellaerstluxation ist eine häufige Verletzung im Bereich des Kniegelenks, insbesondere bei jungen, sportlich aktiven Personen. Diese Verletzung entsteht typischerweise durch ein plötzliches Verdrehungstrauma oder direkte Krafteinwirkung auf das Kniegelenk und ereignet sich meistens nach lateral. Neben dem Trauma gibt es unterschiedliche Risikofaktoren, wie z. B. eine Patella alta oder Trochleadysplasie, die die Wahrscheinlichkeit einer Reluxation signifikant erhöhen. Diagnostisch ist neben der klinischen Untersuchung daher v. a. eine ausführlich Anamnese entscheidend, um Risikofaktoren abzuschätzen – unterstützt durch bildgebende Verfahren wie Röntgenaufnahmen und MRT, um Begleitverletzungen zu identifizieren und anatomische Risikofaktoren zu bestimmen. Ziel ist nach der Primärversorgung und ggf. der Adressierung von Begleitverletzungen stets das Vermeiden einer Reluxation. Nach Algorithmen-adaptierter Abschätzung des Reluxationsrisikos wird die Entscheidung einer weiteren konservativen oder operativen Therapie getroffen. Eine frühzeitige und angemessene Therapie ist essenziell, um die langfristige Funktion des Kniegelenks zu sichern und das Risiko von erneuten Luxationen und chronischer Instabilität zu minimieren.
Voting equilibria and public funding of political parties
Authors: Correa-Lopera Guadalupe , Moreno Bernardo 
Published: September 2024

AbstractDirect public funding to political parties exists in most OECD countries and its allocation is executed on the basis of two principles: (i) proportional to the votes (or alternatively the number of seats), and (ii) equal distribution. We consider a situation in which there are two scenarios and two policies, where the optimal policy for each scenario is different. We study which policy is implemented when public political funding is introduced and voters are uncertain about the realized scenario. First, when the goal is to implement the optimal policy, we find that direct public funding to political parties is necessary if voters are more likely to be right than wrong about the scenario. Second, we characterize all equilibria based on voters’ beliefs, the amount of money proportionally allocated, and the parties’ preferences over the pairs scenario-policy and being in office.
Unterbringungsgesetz (UbG) Novelle 2023
Authors: Baldinger-Melich Pia , Frey Richard 
Published: September 2024

ZusammenfassungSeit dem 1. Juli 2023 ist die Novellierung des Unterbringungsgesetzes in Kraft. Diese hat einige wesentliche Neuerungen mit sich gebracht, wie die Unterscheidung zwischen entscheidungs- und nicht entscheidungsfähigen Patient:innen im Behandlungsrecht und die explizite Erwähnung im Gesetzestext einer Unterstützung der Betroffenen durch eine sogenannte Vertrauensperson. Diese Reform steht im Zeichen einer Förderung der Selbstbestimmung psychisch kranker Personen und verschärft die Aufklärungs‑, Verständigungs- und Dokumentationspflichten des medizinischen Personals, das sich nachweislich um die Einbindung der Patient:innen und ihrer Vertrauenspersonen in Behandlungsentscheidungen bemühen muss. Anhand mehrerer Fallbeispiele sollen die gesetzlichen Neuerungen kritisch diskutiert, die Umsetzbarkeit ebendieser sowie Vor- und Nachteile veranschaulicht werden.
Web-Based DICOM Viewers: A Survey and a Performance Classification
Authors: Pereira Hugo , Romero Luis , Miguel Faria Pedro 
Published: September 2024

AbstractThe standard for managing image data in healthcare is the DICOM (Digital Imaging and Communications in Medicine) protocol. DICOM web-viewers provide flexible and accessible platforms for their users to view and analyze DICOM images remotely. This article presents a comprehensive evaluation of various web-based DICOM viewers, emphasizing their performance in different rendering scenarios, browsers, and operating systems. The study includes a total of 16 web-based viewers, of which 12 were surveyed, and 7 were compared performance-wise based on the availability of an online demo. The criteria for examination include accessibility features, such as available information or requirements for usage, interface features, such as loading capabilities or cloud storage, two-dimensional (2D) viewing features, such as the ability to perform measurements or alter the viewing window, and three-dimensional (3D) viewing features, such as volume rendering or secondary reconstruction. Only 4 of the viewers allow for the viewing of local DICOM files in 3D (other than MPR(Multiplanar reconstruction)). Premium software offers a large amount of features with overall good performance. One of the free alternatives demonstrated the best efficiency in both 2D and 3D rendering but faces challenges with missing 3D rendering features in its interface, which is still in development. Other free options exhibited slower performance, especially in 2D rendering but have more ready-to-use features on their web app. The evaluation also underscores the importance of browser choice, with some browsers performing much better than the competition, and highlights the significance of hardware when dealing with rendering tasks.
Food safety aspects of carbon dots: a review
Authors: Nguyen Duyen H. H. , El-Ramady Hassan , Prokisch József 
Published: September 2024

Abstract
Discovered in 2004, carbon dots have garnered a major attention due to their unique optical properties, nanoscale size, and cost-effectiveness. Their potential uses are applicable for bioimaging, electronics, and the food industry. Carbon dots are promising tools for detecting contaminants, identifying harmful bacteria, and monitoring essential nutrients. Here, we review the safety risks associated with applying carbon dots in the food industry, focusing on their integration into global food safety frameworks. We highlight recent advancements in the detection capabilities of carbon dots, showcasing their sensitivity and specificity in identifying foodborne pathogens and contaminants. We discuss strategies to mitigate potential health risks, such as optimizing carbon dot synthesis to minimize their toxicity and ensuring thorough regulatory assessments. Current research shows that carbon dots improve food safety, but research is needed to address safety concerns and ensure consumer confidence.
Climate change and non-native species in the Spanish Network of National Parks
Authors: Gallardo Belinda , Capdevila-Argüelles Laura 
Published: September 2024

Abstract
The Iberian Peninsula is a primary entry point for non-native species (NNS) into Europe via maritime routes, and is a significant tourist destination. This positions the highly diverse Spanish National Parks at high risk from invasive species, necessitating proactive adaptation and mitigation strategies. We present a comprehensive analysis of the risks posed by NNS to the network of 15 continental and marine National Parks in Spain under climate change, aiming to align management strategies with international Global Biodiversity Framework (GBF) targets. We identified 200 NNS across the network of National Parks, including 78 listed in national NNS regulations. Park managers helped identify 22 priority NNS, including the water hyacinth, American mink, Cape fig and wakame, among others. Over half of the 22 priority NNS (55%) were classified as having a “Major” impact on native biodiversity according to EICAT standards, with another 23% considered “Massive”. Distribution models suggest that rising minimum temperatures could enable NNS to expand in altitude within the parks, particularly in high-mountain parks. Species like the barbary sheep, water hyacinth and largemouth bass may particularly benefit from global warming. Our findings prioritize national parks most vulnerable to the double threat posed by climate change and invasive species, such as Islas Atlánticas, Doñana and Archipelago de Cabrera. We conclude that, in order to progress towards achieving GBF goals, it is essential to: (i) coordinate NNS management efforts across administrations (national and regional), (ii) integrate resources and expertise in a unified strategy against invasion across the network and (iii) enhance public awareness about the risks of introduction and impact of NNS.
70-Gene signature-guided adjuvant systemic treatment adjustments in early-stage ER+ breast cancer patients: 7-year follow-up of a prospective multicenter cohort study
Authors: Verreck Eline E. F. , Kuijer Anne , van Steenhoven Julia E. C. , Volders José H. , van der Velden Annette W. G. , Siesling Sabine , Timmer-Bonte Anja N. H. , Smilde Tineke J. , Imholz Alex L. T. , Blanken-Peeters Charlotte F. J. M. , de Valk Bart , Vrijaldenhoven Suzan , Lastdrager Willem B. , Haringhuizen Annebeth W. , Hunting Jarmo C. B. , Hovenga Sjoerd , Nieboer Peter , Zuetenhorst Hanneke M. , Tetteroo Geert W. M. , Smorenburg Carolien H. , van Maaren Marissa C. , van Dalen Thijs 
Published: September 2024

Abstract

Background
A previous prospective multicenter study revealed the change of the oncologists’ chemotherapy advice due to the 70-Gene signature (GS) test result in half of the estrogen receptor-positive (ER+) invasive early-stage breast cancer patients with disputable chemotherapy indication. This resulted in less patients receiving chemotherapy. This study aims to complement these results by the 7-year oncological outcomes according to the 70-GS test result and the oncologists’ pre-test advice.

Methods
Patients operated for early-stage ER+ breast cancer with disputable chemotherapy indication, had been prospectively included between 2013 and 2015. Oncologists were asked whether they intended to administer adjuvant chemotherapy before deployment of the 70-GS test. Information on adjuvant systemic treatment and oncological outcome was obtained through active follow-up by data managers of the Netherlands Cancer Registry. The primary endpoint of this study was distant metastasis-free survival (DMFS) according to the genomic risk. Exploratory analyses were done to evaluate DMFS in relation to the oncologists’ pre-test advice.

Results
After a median follow-up of 7 years, distant metastases were diagnosed in 23 of the 606 patients (3.8%) and 36 (5.9%) patients had died. The DMFS rate for the 357 70-GS genomic low-risk patients was 94.2% (95% CI 91.2–96.2) and 89.1% for the 249 genomic high-risk patients (95% CI 84.3–92.4). Of the low-risk patients 3% had received chemotherapy compared to 80% of the high-risk patients. For the subgroups based on the pre-test oncologists’ advice (no chemotherapy/chemotherapy/unsure) there were no clinically relevant differences in DMFS (89.8, 93.2 and 92.0%, respectively), while comparable proportions of patients had received chemotherapy.

Conclusions
In patients with early-stage ER+ breast cancer with a disputable chemotherapy indication it is sensible to deploy the 70-GS to better select patients for adjuvant chemotherapy.
Selective mycobacterial capture with ultraviolet-polymerized poly-dimethyldiallyl chloride functionalized surfaces
Authors: Jiang Xuesong , Mathekga Bonolo S. P. , Singh Digvijay , Coon Devin , Sinha Anjana , Armstrong Derek , Acharya Soumyadipta , Mao Hai-Quan , Manabe Yukari C. 
Published: September 2024

AbstractTuberculosis (TB) is the top cause of death from a single infectious pathogen after COVID-19. Despite molecular diagnostic advances, two-thirds of the 10 million annual TB cases are still diagnosed using direct smear microscopy which has ~50% sensitivity. To increase the analytical performance of smear microscopy, we developed and characterized a novel polymer (Polydiallyldimethylammonium chloride [PDADMAC]) engraftment on inexpensive polystyrene (PS) specifically functionalized for mycobacterial capture. Engraftment is achieved via UV photopolymerization of DADMAC monomer on plasma-activated PS. The platform was tested on sputum from presumptive TB cases in Kampala, Uganda (n = 50), with an increased overall sensitivity of 81.8% (27/33) vs. fluorescent smear microscopy 57% (19/33) compared to a molecular (Cepheid GeneXpert MTB/RIF) gold standard. Frugal smear diagnostic innovation that is rapid and does not require dedicated instrumentation may offer an important solution to bridge the TB diagnostic gap.
Graphical Abstract
Bounds for the Gutman–Milovanović index and some applications
Authors: Granados Ana , Portilla Ana , Quintana Yamilet , Tourís Eva 
Published: September 2024

Abstract
In this paper, we examine the Gutman–Milovanović index and establish new upper and lower bounds for it. These bounds include terms related to the general sum connectivity index, the general second Zagreb index, and the hyperbolicity constant of the underlying graph. Also, we model physicochemical properties of polyaromatic hydrocarbons using the Gutman–Milovanović index.
Upregulation of Apoptosis Related Genes in Clinically Normal Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Effort to Maintain Tissue Homeostasis
Authors: Attaran Nima , Coates Philip J , Zborayova Katarina , Sgaramella Nicola , Nylander Karin , Gu Xiaolian 
Published: September 2024

Abstract
Purpose
The field cancerization concept indicates the presence of pre-cancerous changes in clinically normal tissue surrounding the tumor. In squamous cell carcinoma of the oral tongue (SCCOT) which is infrequently linked to human papillomavirus infection, we have previously reported that clinically normal tongue contralateral to tumor (NTCT) is molecularly abnormal. Here, combining our transcriptomic and genomic data, we aimed to investigate the contribution of molecular changes in NTCT to cancer development.

Methods
Microarray gene expression data of 14 healthy controls, 23 NTCT and 29 SCCOT samples were investigated to characterize transcriptional profiles in NTCT. Whole exome sequencing and RNA-sequencing data of paired NTCT and tumor samples from 15 SCCOT patients were used to study correlation between copy number variation and differential gene expression.

Results
Using supervised multivariate partial least squares discriminant analysis, a total of 61 mRNAs that distinguish NTCT from healthy tongue were selected. Functional enrichment analysis of the 22 upregulated genes showed increased “positive regulation of nitrogen compound metabolic process” in NTCT. All 12 genes involved in this process have roles in apoptosis (anti- and/or pro-apoptotic). Compared to healthy controls, Zinc Finger Protein 395 (ZNF395), a pro-apoptotic tumor suppressor located on chromosome 8p, was the only gene showing increased mRNA level in NTCT whereas decreased in SCCOT. Given the frequent loss of chromosome 8p in SCCOT, the impact of ZNF395 copy number variation on gene expression was further examined, revealing a positive correlation between copy number and mRNA level (correlation coefficient = 0.572, p < 0.001).

Conclusion
NTCT is susceptible to malignant transformation, where tissue homeostasis is maintained at least partly through regulation of apoptosis. Loss of the pro-apoptotic gene ZNF395 could thus initiate cancer development.
CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?
Authors: Ocariza Moizle Grace Castro , Paton Louise Nancy , Templeton Evelyn Mary , Pemberton Christopher Joseph , Pilbrow Anna Pauline , Appleby Sarah 
Published: September 2024

AbstractThe heart requires a substantial amount of energy to function, utilising various substrates including lipids, glucose and lactate as energy sources. In times of increased stress, lactate becomes the primary energy source of the heart, but persistently elevated lactate levels are linked to poor patient outcomes and increased mortality. Recently, carnosine dipeptidase II (CNDP2) was discovered to catalyse the formation of Lac-Phe, an exercise-induced metabolite derived from lactate, which has been shown to suppress appetite in mice and reduce adipose tissue in humans. This review discusses CNDP2, including its role in lactate clearance, carnosine hydrolysis, oxidative stress regulation, and involvement in metabolite regulation. The association between CNDP2 and cardiometabolic and renal diseases is also explored, and knowledge gaps are highlighted. CNDP2 appears to be a complex participant in human physiological processes and disease, necessitating additional research to unveil its functions and potential therapeutic applications.
Graphical Abstract
The Jerusalem pilgrimage road in the second temple period: an anthropological and archaeological perspective
Authors: Abadi Omri , Szypuła Bartłomiej , Marciak Michał 
Published: September 2024

AbstractThe pilgrimage to the Second Temple included ceremonial elements of strong spiritual significance that elevated the participants to spiritual exaltation. This ceremonial process began with the first steps pilgrims took from their homes towards Jerusalem and concluded when they reached the Temple. This article presents the ceremonial element of the pilgrimage in light of archaeological and anthropological research, integrated with historical sources and with reference to the topography of Jerusalem and its surroundings (including the use of geographic information systems). These tools are used to retrace the path that pilgrims walked and present what the pilgrimage meant for them. The article also investigates whether the physical act of walking can shape the pilgrimage experience and, if so, how this occurs. It is also argued that the main approach to the Temple Mount for Jewish pilgrims led from the south (via the Kidron and Hinnom valleys), and that the construction of this route was designed with geophysical and architectural details meant to enhance the spiritual experience of the pilgrims.