bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigations On Water Circulation in Animal Sea-Water Basins – On the Example of Seals′ Breeding Pools
Authors: Zima Piotr 
Published: June 2017

Abstract
This paper presents general comments concerning investigations on water circulation in animal breeding pools containing sea water. As an example are given results of computer simulation of water circulation in seals′ breeding pools situated in Marine Station at Hel, belonging to Oceanographic Institute , Gdansk University. A mathematical model of three main pools was prepared with taking into account their inflow and outflow water supply points. Next, the object indication ( tracer) tests were done with the use of mathematical modelling as well as in-situ measurements. For description of flow field in steady conditions a simplified model of 2D flow in the form of Helmholtz biharmonic equation of stream function , recalculated then into velocity vector components, was used. The equation , supplemented with appropriate boundary conditions , was solved numerically by using the finite differences method. The spreading of a substance dissolved in water (tracer) was analyzed by solving 2D equation of transient advecting - dispersing transport. To solve it the finite volumes method was applied. The applied model was verified by conducting the indication tests with the use of the rhodamine WT as a tracer. The obtained results made it possible to reconstruct water circulation within the seals′ pools and identify stagnation zones in which water circulation may be made difficult.
Design of Structure of Tension Leg Platform for 6 MW Offshore Wind Turbine Based On Fem Analysis
Authors: Żywicki Jędrzej , Dymarski Paweł , Ciba Ewelina , Dymarski Czesław 
Published: June 2017

Abstract
The article presents the calculation and design stages of the TLP platform serving as a supporting construction of a 6 MW offshore wind turbine. This platform is designed to anchor at sea at a depth of 60 m. The authors presented the method of parameterization and optimization of the hull geometry. For the two selected geometry variants, the load and motion calculations of the platform subjected to wind, wave and current under 50-year storm conditions were performed. The maximum load on the structure was determined in these extreme storm conditions. For these loads, the MES calculation of the designed platform was performed for the selected variant. Authors have presented a method for calculating maximum wind, wave and current stresses on the structure during the worst storm in the past 50 years. For these loads the MES endurance calculations of the designed platform were made. Based on the results of these calculations, the required structural changes and recalculations have been made in succession to the structural design of the platform, which meets the design requirements and has the required ad hoc strength. The article contains stress analysis in „difficult“ nodes of constructions and discusses ways of solving their problems. The work is part of the WIND-TU-PLA project from the NCBR Research Agreement (Agreement No. MARTECII / 1/2014).
Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy
Authors: Eveno Clarisse , Haidara Aminata , Ali Ibrahim , Pimpie Cynthia , Mirshahi Massoud , Pocard Marc 
Published: June 2017

AbstractBackgroundPressurised intraperitoneal aerosol chemotherapy (PIPAC) is a novel technique of intraperitoneal chemotherapy devoted to unresectable peritoneal metastasis (PM). The first results obtained with PIPAC in preclinical models of colon cancer are presented here.MethodsIn vitro, PIPAC (normotherm oxaliplatin at 0.028 mg/mL for 10 min at 1.6 bars) and HIPEC (hyperthermic oxaliplatin at 0.14 mg/mL for 30 min) were compared using the apoptosis and proliferation assay on two colon cancer cell lines (LS 174 and CT 26); ex vivo tumours from an orthotopic mouse model of PM and non-tumour peritoneum from a patient treated according to the two modalities were assessed, investigating the percentage of penetration of oxaliplatin in the tumour and oxaliplatin concentration below the peritoneum. In vivo, a mouse model of colon (CT 26) PM was used to create a PIPAC model (same modalities) for the comparison of IV oxaliplatin (at 5 mg/mL).ResultsIn vitro, the rate of apoptotic and proliferative cells as well as the level of oxaliplatin penetration in tumour nodes was higher in PIPAC groups with less systemic passage through the peritoneum. In vivo, in the colon PM mouse model, the peritoneal cancer index (PCI) was decreased to the same level using PIPAC or IV oxaliplatin. Systemic passage was lower in the PIPAC group.ConclusionsPIPAC with low-dose oxaliplatin is efficient in both in vitro and in vivo models of colon PM. Lower concentrations of chemotherapy are needed in PIPAC to achieve the same effect as IV chemotherapy on PCI. With a very low systemic oxaliplatin passage, this technique of drug delivery seems to be as effective as IV delivery for PM control.
Cultural differences and their impact on the ecumenical issue in today’s Judaism
Authors: Pătru Alina 
Published: June 2017

Abstract
It is not only the case of Christianity that different religious options spring from cultural differences, but it goes the same for other religions too, even for ethnic religions. Using the example of today Judaism, this study seeks to show how different cultural backgrounds lead to different religious forms, and how they may bring about tensions between members of the same religion. I shall bring up to discussion situations where the cultural differences are finally bridged, as well as others where they persist, feeding the strained relationship. Via the example of Judaism, I shall elaborate on the importance of non-religious factors in the appearance of confessional differences and the attitude towards other practitioners. The material allows theologians to draw a comparison with the situation within Christianity and to reach to useful conclusions for Christian ecumenism.
Rapid liquid chromatography tandem mass spectrometry determination of rivaroxaban levels in human plasma for therapeutic drug monitoring
Authors: Varga Andreea , Șerban Răzvan Constantin , Muntean Daniela Lucia , Tătar Cristina Maria , Farczadi Lenard , Tilea Ioan 
Published: June 2017

Abstract
A rapid, sensitive, high-throughput liquid chromatography coupled with tandem mass spectrometry method for the quantification of rivaroxaban from human plasma has been developed and validated. For the analytical separation a Zorbax SB-C18 column with isocratic flow of mobile phase composed of 0.2% formic acid in water and acetonitril (65:35, V/V) with a flow rate of 1 mL/min at a temperature of 45ºC was used. Detection of rivaroxaban was performed using positive electrospray ionization and MS/MS mode (sum of m/z 231.1; 289.2 and 318.2 from m/z 436.3). Plasma samples were prepared using single-step protein precipitation with methanol. Method validation was performed with regards to selectivity, linearity (r >0.9927), within-run and between-run precision (CV< 13.1 %) and accuracy (bias< 9.4 %) over a concentration range of 24.00 - 960.00 ng/mL plasma. Recovery was between 96.5 - 108.5% and the lower limit of quantification of rivaroxaban was 24.00 ng/mL. The developed method is simple, rapid, and selective, requires small plasma sample volumes, and was successfully applied for therapeutic drug monitoring of rivaroxaban in treated patients.
Robin Hood: A cost-efficient two-stage approach to large-scale simultaneous inference with non-homogeneous sparse effects
Authors: Pecanka Jakub , Goeman Jelle 
Published: June 2017

AbstractA classical approach to experimental design in many scientific fields is to first gather all of the data and then analyze it in a single analysis. It has been recognized that in many areas such practice leaves substantial room for improvement in terms of the researcher’s ability to identify relevant effects, in terms of cost efficiency, or both. Considerable attention has been paid in recent years to multi-stage designs, in which the user alternates between data collection and analysis and thereby sequentially reduces the size of the problem. However, the focus has generally been towards designs that require a hypothesis be tested in every single stage before it can be declared as rejected by the procedure. Such procedures are well-suited for homogeneous effects, i.e. effects of (almost) equal sizes, however, with effects of varying size a procedure that permits rejection at interim stages is much more suitable. Here we present precisely such multi-stage testing procedure called Robin Hood. We show that with heterogeneous effects our method substantially improves on the existing multi-stage procedures with an essentially zero efficiency trade-off in the homogeneous effect realm, which makes it especially useful in areas such as genetics, where heterogeneous effects are common. Our method improves on existing approaches in a number of ways including a novel way of performing two-sided testing in a multi-stage procedure with increased power for detecting small effects.
Stress-Dilatancy for Soils. Part III: Experimental Validation for the Biaxial Condition
Authors: Szypcio Zenon 
Published: June 2017

Abstract
The validation of the general stress-dilatancy relationship is shown based on biaxial compression test data presented in the literature under drained and undrained conditions. Rowe’s and Bolton’s relationships can be treated as simplified forms of the general stress-dilatancy relationship. The stress ratio values are a function of not only the dilatancy but also the intermediate principal stress, the non-coaxiality angle defined by Gutierrez and Ishihara and the stress-strain path. For many granular soils, the critical frictional state angle of the shearing resistance Φo = Φ′cv and parameters α and β are functions of the drainage condition, the stress level and the stress and strain paths.
Survival of node-negative breast cancer patients treated at the university medical centre Maribor in the period 2000–2009
Authors: Fokter Dovnik Nina , Arko Darja , Čas Sikošek Nina , Takač Iztok 
Published: June 2017

AbstractIntroductionBreast cancer is increasingly diagnosed in the early stages without regional nodal involvement. The aim of the present study was to determine the 5-year overall (OS) and breast cancer specific survival (BCSS) for patients with node-negative breast cancer treated at the University Medical Centre Maribor, and compare it with survival at the national level.MethodsMedical records were searched for information on patients with lymph node-negative invasive breast cancer who received primary treatment at the University Medical Centre Maribor in the period 2000–2009. Information on all Slovenian node-negative breast cancer patients diagnosed in the same period was obtained from the Cancer Registry of Republic of Slovenia. Time trends in survival were assessed by comparing the periods 2000–2004 and 2005–2009.ResultsThe 5-year OS and BCSS of patients treated in Maribor in the period 2000–2009 were 92.3% (95% CI, 90.5%– 94.1%) and 96.4% (95% CI, 95.2%–97.6%), respectively, and did not differ from the corresponding OS and BCSS for Slovenian patients. Although the improvement in OS for patients from Maribor diagnosed in the period 2005–2009 compared to 2000–2004 did not reach statistical significance (HR 0.73; 95% CI, 0.51–1.05; p=0.086), BCSS significantly improved over the same time periods (HR 0.53; 95% CI, 0.30–0.94; p=0.028).ConclusionsSurvival of node-negative breast cancer patients treated at the University Medical Centre Maribor is comparable to survival of corresponding patients at the national level. The rising number of long-term breast cancer survivors places additional importance on survivorship care.
White matter sexual dimorphism of the adult human brain
Authors: Bourisly Ali K. , Gejo Grace , Hayat Abrar A. , Alsarraf Lamya , Dashti Fatima M. , Di Paola Margherita 
Published: June 2017

AbstractSex-biased psychophysiology, behavior, brain function, and conditions are extensive, yet underlying structural brain mechanisms remain unclear. There is contradicting evidence regarding sexual dimorphism when it comes to brain structure, and there is still no consensus on whether or not there exists such a dimorphism for brain white matter. Therefore, we conducted a voxel-based morphometry (VBM) analysis along with global volume analysis for white matter across sex. We analyzed 384 T1-weighted MRI brain images (192 male, 192 female) to investigate any differences in white matter (WM) between males and females. In the VBM analysis, we found males to have larger WM, compared to females, in occipital, temporal, insular, parietal, and frontal brain regions. In contrast, females showed only one WM region to be significantly larger than males: the right postcentral gyrus in the parietal lobe region. Although, on average, males showed larger global WM volume, we did not find any significant difference in global WM volume between males and females.
Building verbs in language mixing varieties
Authors: Alexiadou Artemis 
Published: June 2017

Abstract
This paper discusses two patterns of language mixing involving verbal predicates produced by bilingual speakers,
the so-called light verb construction and the so-called affixal pattern. The empirical focus of the study is on Greek-German
and Cypriot Greek-English varieties, which are contrasted to the Spanish-German variety discussed in González-Vilbazo
and López (2011). An analysis of the constructions is offered using the tools of Distributed Morphology and Minimalist
Syntax. The paper shows that bilingual speakers have very detailed knowledge of fine properties of their two linguistic
systems that become apparent in the context of building verbs.
Supramolecular architectures in N-(4-bromobenzoyl)-arylsulfonamides: crystal structures and Hirshfeld surface analysis
Authors: Naveen Shivalingegowda , Sudha Achar Gurumurthy , Suresha Erachikkaiah , Lokanath Neratur Krishnappagowda , Suchetan Parameshwar Adimule 
Published: June 2017

Abstract
A detailed analysis of the molecular packing of five N-(4-bromobenzoyl)-substituted benzenesulfonamides, i-X~4-Br (1–5) [i-X=H, 2-CH3, 4-CH3, 2-Cl, 4-Cl] is presented. The intermolecular interactions and the packing patterns are evaluated along with an analysis of their Hirshfeld surfaces and fingerprint plots (FP). The crystals feature molecular self-assembly through N–H···O hydrogen-bonds forming three types of supramolecular synthon:

C

1
1

(
4
)

${\rm{C}}_1^1(4)$

chain,

R
4
4

(
16
)

${\rm{R}}_4^4(16)$

tetramer and

R
2
2

(
8
)

${\rm{R}}_2^2(8)$

ring. These molecular assemblies extend to form one-dimensional (1D), 2D or 3D supramolecular architectures via diverse intermolecular interactions. A study of 33 i-X~4-Y (Y=H, CH3, OCH3, NO2, F, Cl, Br) structures shows the substituent on the sulfonamide ring modulates the intermolecular interactions and the subsequent supramolecular architectures drastically, with the fluoro- and bromo-substituted analogues providing distinctive self-assemblies. The

R
4
4

(
16
)

${\rm{R}}_4^4(16)$

synthon produced by N–H···O hydrogen-bonds in the 4-CH3~4-Br derivative is a rare phenomenon amongst a set of 74 i-X~j-Y structures.
RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for Caenorhabditis elegans Larval Development
Authors: Zabinsky Rebecca A , Weum Brett M , Cui Mingxue , Han Min 
Published: June 2017

Abstract
Extensive studies have suggested that most miRNA functions are executed through complex miRNA-target interaction networks, and such networks function semiredundantly with other regulatory systems to shape gene expression dynamics for proper physiological functions. We found that knocking down vgln-1, which encodes a conserved RNA-binding protein associated with diverse functions, causes severe larval arrest at the early L1 stage in animals with compromised miRISC functions (an ain-2/GW182 mutant). Through an enhancer screen, we identified five specific miRNAs, and miRNA families, that act semiredundantly with VGLN-1 to regulate larval development. By RIP-Seq analysis, we identified mRNAs that are directly bound by VGLN-1, and highly enriched for miRNA binding sites, leading to a hypothesis that VGLN-1 may share common targets with miRNAs to regulate gene expression dynamics for development.
Heat-Induced Calcium Leakage Causes Mitochondrial Damage in Caenorhabditis elegans Body-Wall Muscles
Authors: Momma Kenta , Homma Takashi , Isaka Ruri , Sudevan Surabhi , Higashitani Atsushi 
Published: June 2017

Abstract
Acute onset of organ failure in heatstroke is triggered by rhabdomyolysis of skeletal muscle. Here, we showed that elevated temperature increases free cytosolic Ca2+ [Ca2+]f from RYR (ryanodine receptor)/UNC-68 in vivo in the muscles of an experimental model animal, the nematode Caenorhabditis elegans. This subsequently leads to mitochondrial fragmentation and dysfunction, and breakdown of myofilaments similar to rhabdomyolysis. In addition, treatment with an inhibitor of RYR (dantrolene) or activation of FoxO (Forkhead box O)/DAF-16 is effective against heat-induced muscle damage. Acute onset of organ failure in heatstroke is triggered by rhabdomyolysis of skeletal muscle. To gain insight into heat-induced muscle breakdown, we investigated alterations of Ca2+ homeostasis and mitochondrial morphology in vivo in body-wall muscles of C. elegans exposed to elevated temperature. Heat stress for 3 hr at 35° increased the concentration of [Ca2+]f, and led to mitochondrial fragmentation and subsequent dysfunction in the muscle cells. A similar mitochondrial fragmentation phenotype is induced in the absence of heat stress by treatment with a calcium ionophore, ionomycin. Mutation of the unc-68 gene, which encodes the ryanodine receptor that is linked to Ca2+ release from the sarcoplasmic reticulum, could suppress the mitochondrial dysfunction, muscle degeneration, and reduced mobility and life span induced by heat stress. In addition, in a daf-2 mutant, in which the DAF-16/FoxO transcription factor is activated, resistance to calcium overload, mitochondrial fragmentation, and dysfunction was observed. These findings reveal that heat-induced Ca2+ accumulation causes mitochondrial damage and consequently induces muscle breakdown.
Artistic foundations of the Carmelite Order in Silesia in early modern times. Selected issues
Authors: Galewski Dariusz 
Published: June 2017

The Order of The Brothers of The Most Blessed Virgin Mary of Mount Carmel arrived in Silesia late in the 14th century, when its first monastery was established in Strzegom. It was however liquidated during the Reformation. Only after the end of the Thirty Years’ War was it successfully regained, and three new locations were opened in Głębowice, Wołów, and Kożuchów. Baron Johann Adam de Garnier, a colonel of the imperial army hailing from Alsace, owner of the estate in Głębowice, played a major role in their design and development. The first two centres are impressive Baroque projects with lavishly furnished churches, while the third is a mediaeval castle entrusted to the monks late in the 17th century and adapted into a monastery, which, besides the Jesuit Otyń, is considered a singularity in Silesia. The essay presents the artistic achievement of Silesian Carmelites based on the state-of-the-art research and emphasises the role of the founder. It is also an attempt at assessing the contribution of the Order to the development of Baroque culture and art in Silesia, which is modest, especially when compared to the neighbouring regions of the Commonwealth of Poland–Lithuania. It also emphasised the absence of the reformed branch of the Order, that is the Discalced Carmelites, in the area. Although the achievements of the Carmelites would be difficult to compare with the impressive heritage of Cistercians and Jesuits who dominated the religious and artistic realm of post-Tridentine Catholic Church in Silesia, it nonetheless merits the interest of researchers in various fields of culture and art.
Związki teologii krzyża św. Bonawentury z mistyką Karmelu. Z kręgu powinowactwa sztuki franciszkańskiej i karmelitańskiej na wybranych przykładach sztuki z XIV i początku XV wieku
Authors: Mazurczak Urszula 
Published: June 2017

Pokaźna spuścizna badawcza ojca karmelity Bienignusa Wanata, profesora historii sztuki, inspiruje do dalszych badań – aby wyjaśnić plastykę powstałą w obrębie karmelu w średniowieczu, która była kontynuowana w czasach nowożytnych. W niniejszej pracy zaprezentowany został motyw krzyża jako Lignum Vitae, znany najwcześniej z drobnej plastyki Palestyny obszaru życia pierwszych karmelitów. Podejmujemy próbę związania tej formy krzyża utrwalonej na dewocyjnych przedmiotach przywożonych do Europy z Ziemi Świętej, z tradycją kultu zarówno Maryi, jak i Krzyża. Wskazuje się na pierwsze eremy w Palestynie, następnie na osiedlenie się karmelitów w Italii w połowie XIII i w XIV wieku. Istnieją związki eremickiego życia karmelitów z pierwotnymi formami życia franciszkanów w Italii, zwłaszcza w Umbrii. Podejmowane były w nauce główne kierunki pobożności, następnie kształcenia uniwersyteckiego karmelitów w Italii w XIII i początku XIV wieku. Wskazano na ich ścisły związek z nauką św. Tomasza z Akwinu i pobożnością dominikańską, którą kontynuowali wielcy mistycy karmelu w XVII wieku.W niniejszej pracy wskazuje się na nurt pobożności franciszkańskiej i związek z kontemplacją Krzyża jako Drzewa Życia, którego forma asymilowana była poprzez import z Palestyny ampułek na świętą oliwę oraz innych przedmiotów wotywnych. Taki motyw krzyża znany w ikonografii franciszkańskiej został zaasymilowany również do pobożności karmelu choć wielość konkretnych dzieł sztuki pochodzi z czasów nowożytnych, co potwierdza np. krucyfiks z kościoła pokarmelickiego w Warszawie. Pisma i traktaty św. Bonawentury czytano i kontemplowano w środowisku karmelickim Teksty te ugruntowały motywy krzyża w sztuce.
The history of the foundation of the Calced Carmelite Church in Wola Gułowska
Authors: Rolska Irena 
Published: June 2017

In 1633, Ludwik Krasiński († after 1644) was given a consent by Bishop Jan Albert Waza to establish a Calced Carmelite monastery on Krasiński’s property in Wola Gułowska. The foundation of the Carmelite congregation, far from much frequented trails, was in line with eremitic ideas and spirituality of the order. The Wola Gułowska monastery became a second largest (after Krakow) Carmelite monastery in terms of the number of monks. The monastery in Wola Gułowska had a formative character, with the novitiate and philosophical studies. In the 17th century the church became an important Marian sanctuary, as it possessed a much venerated painting of the Virgin Mary with the baby Jesus dating back to the early 15th, late 16th century.The construction of the church, commenced in 1659, took considerable funds. Not only was it supported by the Krasiński family, but also by many representatives of aristocratic families, local landlords and priests, such as canons Michał Krassowski and Mikołaj Firlej. The three-nave basilica church was being built for over 100 years and in several stages. It was the funds gathered in the 18th century that allowed the builders to complete the two-tower partitioned facade in the years 1770–1780. In the middle of the 18th century, the altars were made in the church by monastic sculptors Grzegorz Kaczyrek and Izydor Mastalski. The seventeenth-century designers of the church or of its eighteenth century façade still remain unknown.