bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lab-on-chip technology for chronic disease diagnosis
Authors: Wu Jiandong , Dong Meili , Rigatto Claudio , Liu Yong , Lin Francis 
Published: January 2018

AbstractVarious types of chronic diseases (CD) are the leading causes of disability and death worldwide. While those diseases are chronic in nature, accurate and timely clinical decision making is critically required. Current diagnosis procedures are often lengthy and costly, which present a major bottleneck for effective CD healthcare. Rapid, reliable and low-cost diagnostic tools at point-of-care (PoC) are therefore on high demand. Owing to miniaturization, lab-on-chip (LoC) technology has high potential to enable improved biomedical applications in terms of low-cost, high-throughput, ease-of-operation and analysis. In this direction, research toward developing new LoC-based PoC systems for CD diagnosis is fast growing into an emerging area. Some studies in this area began to incorporate digital and mobile technologies. Here we review the recent developments of this area with the focus on chronic respiratory diseases (CRD), diabetes, and chronic kidney diseases (CKD). We conclude by discussing the challenges, opportunities and future perspectives of this field.
A dataset of 200 structured product labels annotated for adverse drug reactions
Authors: Demner-Fushman Dina , Shooshan Sonya E. , Rodriguez Laritza , Aronson Alan R. , Lang Francois , Rogers Willie , Roberts Kirk , Tonning Joseph 
Published: January 2018

AbstractAdverse drug reactions (ADRs), unintended and sometimes dangerous effects that a drug may have, are one of the leading causes of morbidity and mortality during medical care. To date, there is no structured machine-readable authoritative source of known ADRs. The United States Food and Drug Administration (FDA) partnered with the National Library of Medicine to create a pilot dataset containing standardised information about known adverse reactions for 200 FDA-approved drugs. The Structured Product Labels (SPLs), the documents FDA uses to exchange information about drugs and other products, were manually annotated for adverse reactions at the mention level to facilitate development and evaluation of text mining tools for extraction of ADRs from all SPLs. The ADRs were then normalised to the Unified Medical Language System (UMLS) and to the Medical Dictionary for Regulatory Activities (MedDRA). We present the curation process and the structure of the publicly available database SPL-ADR-200db containing 5,098 distinct ADRs. The database is available at https://bionlp.nlm.nih.gov/tac2017adversereactions/; the code for preparing and validating the data is available at https://github.com/lhncbc/fda-ars.
All Biomass and UV Protective Composite Composed of Compatibilized Lignin and Poly (Lactic-acid)
Authors: Kim Youngjun , Suhr Jonghwan , Seo Hee-Won , Sun Hanna , Kim Sanghoon , Park In-Kyung , Kim Soo-Hyun , Lee Youngkwan , Kim Kwang-Jin , Nam Jae-Do 
Published: January 2018

AbstractUtilization of carbon-neutral biomass became increasingly important due to a desperate need for carbon reduction in the issue of global warming in light of replacing petroleum-based materials. We used lignin, which was an abundant, low cost, and non-food based biomass, for the development of all biomass-based films and composites through reactive compatibilization with poly (lactic-acid) (PLA). Using a facile and practical route, the hydrophilic hydroxyl groups of lignin were acetylated to impose the compatibility with PLA. The solubility parameter of the pristine lignin at 26.3 (J/cm3)0.5 was altered to 20.9 (J/cm3)0.5 by acetylation allowing the good compatibility with PLA at 20.2 (J/cm3)0.5. The improved compatibility of lignin and PLA provided substantially decreased lignin domain size in composites (12.7 μm), which subsequently gave transparent and UV-protection films (visual transmittance at 76% and UV protection factor over 40). The tensile strength and elongation of the developed composite films were increased by 22% and 76%, respectively, and the biobased carbon content was confirmed as 96 ± 3%. The developed PLA/lignin composites provided 100% all-biomass contents and balanced optical and mechanical properties that could broaden its eco-friendly applications in various industries.
Effectiveness of a Method for Teaching Self-Compassion to Communication Sciences and Disorders Graduate Students
Authors: Beck Ann R. , Verticchio Heidi 
Published: January 2018

Purpose
The purpose of this study is to explore the effects of a daily mindfulness practice and 2 types of journaling on participants' development of self-compassion.

Method
This was a between-groups design. All participants in a graduate counseling course engaged in a short daily mindfulness practice at the beginning of every class. Participants were randomly assigned to a counseling journal or a gratitude journal group. Participants were to write in their journals 2 to 5 times a week for the duration of the class. Participants completed the Self-Compassion Scale (Neff, 2003) and a questionnaire created by the 1st author before any mindfulness sessions were held and again at the completion of the course.

Results
Participants' level of self-compassion increased from pretest to posttest. The self-compassion scores of participants who kept counseling journals increased more than did those of participants who kept gratitude journals. Qualitative data indicated that participants believed that mindfulness was an important quality for clinicians to possess and that they were accepting of the daily mindfulness practice.

Conclusions
Engaging in a 12-min daily mindfulness practice utilizing simple yoga postures, breath work, reflective writing, and journaling done at a separate time appears to be an effective technique for increasing students' levels of self-compassion. Maintaining a counseling journal as opposed to a gratitude journal appears to enhance the effect of the daily mindfulness practice on self-compassion.
Concurrent Validity and Reliability for the Communication Complexity Scale
Authors: Brady Nancy C. , Fleming Kandace , Romine Rebecca Swinburne , Holbrook Alison , Muller Kristen , Kasari Connie 
Published: January 2018

Purpose
The Communication Complexity Scale (CCS; Brady et al., 2012) was created to fill a void in measures of expressive communication skills in individuals who communicate primarily with presymbolic or early symbolic means. CCS scores reflect expressive communication observed during interactive communication contexts.

Method
Two studies were completed to examine the reliability and validity of the revised CCS scores. Participants in both studies had minimal verbal skills (i.e., produced less than 20 functional words). Study 1 examined interobserver agreement, test–retest reliability, and concurrent validity for 239 participants with intellectual disabilities between the ages of 3–66 years, assessed with the protocol developed at the University of Kansas (KU CCS). CCS scores were compared with scores from the Vineland Adaptive Behavior Scales–Second Edition (Sparrow, Cicchetti, & Balla, 2005) and the Communication Matrix (Rowland & Fried-Oken, 2010). Study 2 examined the reliability and concurrent validity for CCS scores derived from 110 children (chronological age = 3–9) with autism from diverse backgrounds. These children were assessed with the Early Social Communication Scale (Mundy et al., 2003). CCS scores were compared with rates of communication derived from the Early Social Communication Scale.

Results
CCS scores were moderately correlated with scores from existing measures of early communication. In addition, CCS scores from different raters were reliable, and test–retest scores were highly similar.

Conclusions
These findings support the validity and reliability of the CCS when used with individuals across a wide range of ages and with various types of disabilities. The CCS can be used in research and clinical practice to describe extant communication levels in individuals with minimal verbal skills.
Observations of white-light flares in NOAA active region 11515: high occurrence rate and relationship with magnetic transients
Authors: Song Y. L. , Tian H. , Zhang M. , Ding M. D. 
Published: January 2018

Aims. There are two goals in this study. One is to investigate how frequently white-light flares (WLFs) occur in a flare-productive active region (NOAA active region 11515). The other is to investigate the relationship between WLFs and magnetic transients (MTs).
Methods. We used the high-cadence (45 s) full-disk continuum filtergrams and line-of-sight magnetograms taken by the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory (SDO) to identify WLFs and MTs, respectively. Images taken by the Atmospheric Imaging Assembly (AIA) on board SDO were also used to show the flare morphology in the upper atmosphere.
Results. We found at least 20 WLFs out of a total of 70 flares above C class (28.6%) in NOAA active region 11515 during its passage across the solar disk (E45°–W45°). Each of these WLFs occurred in a small region, with a short duration of about 5 min. The enhancement of the white-light continuum intensity is usually small, with an average enhancement of 8.1%. The 20 WLFs we observed were found along an unusual configuration of the magnetic field that was characterized by a narrow ribbon of negative field. Furthermore, the WLFs were found to be accompanied by MTs, with radical changes in magnetic field strength (or even a sign reversal) observed during the flare. In contrast, there is no obvious signature of MTs in the 50 flares without white-light enhancements.
Conclusions. Our results suggest that WLFs occur much more frequently than previously thought, with most WLFs being fairly weak enhancements. This may explain why WLFs are reported rarely. Our observations also suggest that MTs and WLFs are closely related and appear cospatial and cotemporal, when considering HMI data. A greater enhancement of WL emission is often accompanied by a greater change in the line-of-sight component of the unsigned magnetic field. Considering the close relationship between MTs and WLFs, many previously reported flares with MTs may be WLFs.
The Bronchus First and Vessels Simultaneously Stapled Technique: A Safe and Simple Method for Video-Assisted Right Upper Lobe Lobectomy
Authors: Xu Hao , Zhang Linyou 
Published: January 2018

Objective Video-assisted thoracic surgery lobectomy is a minimally invasive procedure for major pulmonary resection. The purpose of this study was to present a novel approach with a thoracoscope in the right upper lobe and to compare different lobectomy methods at our institution.
Methods We reviewed the medical records of patients who underwent a thoracoscopic right upper lobectomy for lung cancer between September 2015 and September 2016. We performed 128 thoracoscopic right upper lobectomies: group A (n = 50) was treated with the bronchus-first and vessels simultaneously stapled method and group B (n = 78) was treated with the conventional isolation–ligation method. Preoperative mediastinal staging and lymphadenectomy followed the National Comprehensive Cancer Network guidelines. The intra- and postoperative outcomes were recorded and statistically compared.
Results All patients underwent successful thoracoscopic right upper lobectomies. No significant differences in mean intraoperative blood loss, massive hemorrhage (>500 mL), and postoperative complications were observed between the two groups (p < 0.05). The mean operative time of group A was less than that of group B (110.80 ± 34.74 versus 167.01 ± 48.38 minutes, p = 0.000). The mean duration of chest drainage in group A was 4.34 ± 2.06 days, which was shorter than that of group B (5.85 ± 3.13 days, p = 0.017). No significant differences were observed in the local recurrence and distant recurrence between the two groups during the postoperative follow-up.
Conclusions Thoracoscopic right upper lobectomy with the lobectomy bronchus-first and vessels simultaneously stapled method is a safe and efficient procedure that leads to better recovery.
Long-Term Skeletal Outcomes of Primary Hyperparathyroidism Patients After Treatment with Parathyroidectomy: A Systematic Review and Meta-Analysis
Authors: Zhang Lu , Liu Xiaomei , Li Hongwei 
Published: January 2018

AbstractThe aim of the study was to assess and define the association between parathyroidectomy (PTX) and long-term skeletal outcomes in primary hyperparathyroidism (PHPT) patients. PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were systematically searched up to June 31, 2017, without language restriction. Any study comparing skeletal outcomes [fracture risk or bone mineral density (BMD)] of PHPT patients after more than 12 months of PTX treatment versus non-PTX treatment was included. Pooled relative risks or odds ratios with 95% confidence intervals and weighted mean difference were calculated using random-effects models irrespective of statistical heterogeneity assessed by I2 statistic. Finally, 5 randomized controlled trials (RCTs, n=584) and 10 cohort studies (CSs, n=12202) were included. CSs suggest PTX treatment versus non-PTX treatment is significantly associated with 36% reduction in the risk of fracture, with no heterogeneity, and an increase in the lumbar spine change by 0.55 WMD, with no heterogeneity. RCTs indicate PTX treatment versus non-PTX treatment is significantly associated with BMD change of 0.97 WMD at the lumbar spine with substantial heterogeneity, and 1.23 WMD at the femoral neck with no heterogeneity. The existing CSs indicate PTX-treatment versus non-PTX-treatment might reduce the risk of fracture in PHPT patients. The existing RCTs do not provide sufficient or precise evidence that PTX-treatment affects the fracture risk of PHPT patients, but offer data that subsets of patients who could potentially benefit from PTX-treatment can be identified.
Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors
Authors: Filatova Lyubov Yu. , Klyachko Natalia L. , Kudryashova Elena V. 
Published: January 2018

The development of systems for targeted delivery of anti-tuberculosis drugs is a challenge of modern biotechnology. Currently, these drugs are encapsulated in a variety of carriers such as liposomes, polymers, emulsions and so on. Despite successful in vitro testing of these systems, virtually no success was achieved in vivo, because of low accessibility of the foci of infection located in alveolar macrophage cells. A promising strategy for increasing the efficiency of therapeutic action of anti-tuberculosis drugs is to encapsulate the agents into mannosylated carriers targeting the mannose receptors of alveolar macrophages. The review addresses the methods for modification of drug substance carriers, such as liposomes and biodegradable polymers, with mannose residues. The use of mannosylated carriers to deliver anti-tuberculosis agents increases the drug circulation time in the blood stream and increases the drug concentration in alveolar macrophage cells.
The bibliography includes 113 references.
Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation
Authors: Betts Brian C. , Bastian David , Iamsawat Supinya , Nguyen Hung , Heinrichs Jessica L. , Wu Yongxia , Daenthanasanmak Anusara , Veerapathran Anandharaman , O’Mahony Alison , Walton Kelly , Reff Jordan , Horna Pedro , Sagatys Elizabeth M. , Lee Marie C. , Singer Jack , Chang Ying-Jun , Liu Chen , Pidala Joseph , Anasetti Claudio , Yu Xue-Zhong 
Published: January 2018

Significance
Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality among allogeneic stem-cell transplantation recipients. An effort to identify selective immune suppression whereby GVHD is reduced and the antitumor activity of the graft is preserved is key to improving the success of blood and marrow transplantation. Here we demonstrate that inhibition of Janus kinase 2 (JAK2) significantly decreases GVHD and maintains tumor killing by the donor T cells. Pharmacologic blockade of JAK1 and JAK2 in myelofibrosis patients is known to impair human T cell subsets broadly. Conversely, we show that JAK2 inhibition impairs alloreactive T cells yet promotes beneficial regulatory T cell and Th2 differentiation. This study emphasizes the relevance of JAK2 in GVHD pathogenesis and prevention.
RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism
Authors: Liu Wenjing , Chen Binbin , Wang Yang , Meng Chenling , Huang Huihui , Huang Xiao-Ru , Qin Jinzhong , Mulay Shrikant R. , Anders Hans-Joachim , Qiu Andong , Yang Baoxue , Freeman Gordon J. , Lu Hua Jenny , Lin Herbert Y. , Zheng Zhi-Hua , Lan Hui-Yao , Huang Yu , Xia Yin 
Published: January 2018

Significance
Necroptosis is critically involved in the development of acute kidney injury (AKI), but it has not been well demonstrated that necroptosis occurs in renal tubular epithelial cells in vivo during AKI. Now, we provide evidence that renal proximal tubular cells undergo necroptosis during ischemia/reperfusion injury or oxalate nephropathy. Repulsive guidance molecule-b protects against AKI by inhibiting mixed lineage kinase domain-like membrane association and necroptosis in proximal tubular cells.
Quantitative Research on the Relationship between Yield of Winter Wheat and Agroclimatological Resources—the Case Study from Yanzhou District, Shandong Province, China
Authors: Yan Maoling , Liu Pingzeng , Zhang Chao , Zheng Yong , Wang Xizhi , Zhang Yan , Chen Weijie , Zhao Rui 
Published: January 2018

AbstractAgroclimatological resources provide material and energy for agricultural production. This study is aimed to analyze the impact of selected climate factors change on wheat yield over the different growth period applied quantitatively method, by comparing two different time division modules of wheat growth cycle- monthly empirical-statistical multiple regression models ( From October to June of next year ) and growth stage empirical-statistical multiple regression models (Including sowing stage, seedling stage, tillering stage, overwintering period, regreening period, jointing stage, heading stage, maturity stage) analysis of relationship between agrometeorological data and growth stage records and winter wheat production in Yanzhou, Shandong Province of China. Correlation analysis(CA)was done for 35 years (from 1981 to 2015) between crop yield and corresponding weather parameters including daily mean temperature, sunshine duration, and average daily precipitation selected from 18 different meteorological factors. The results shows that the greatest impact on the winter wheat yield is the precipitation overwintering period in this area, each 1mm increase in daily mean rainfall was associated with 201.64 kg/hm2 lowered output. Moreover, the temperature and sunshine duration in heading period and maturity stage also exert significant influence on the output, every 1°C increase in daily mean temperature was associated with 199.85kg/hm2 adding output, every 1h increase in mean sunshine duration was associated with 130.68kg/hm2 reduced output. Comparing with the results of experiment which using months as step sizes and using farming as step sizes was in better agreement with the fluctuation in meteorological yield, offered a better explanation on the growth mechanism of wheat. Eventually the results indicated that 3 factors affects the yield during different growing periods of wheat in different extent and provided more specific reference to guide the agricultural production management in this area.
A Shortened Version of the Reasons for Living—Older Adults Scale for Clinical and Research Utility
Authors: Lutz Julie , Edelstein Barry , Katz Emma , Gallegos Jarred V 
Published: January 2018

Abstract

Background and Objectives
Older adults have elevated suicide rates, and identification of protective factors, such as reasons for living, is important in preventing suicide. The Reasons for Living—Older Adults scale (RFL-OA) is a 69-item measure of these protective factors in late life, which yields good psychometric properties. However, its length limits its utility in some clinical and research contexts where a shorter measure is ideal. The objective of this study was to create a shortened version of the RFL-OA.

Research Design and Methods
First, data collected previously during validation of the original RFL-OA (n = 199, age 65 and older, 65% female) were used to select 30 items, spanning all content areas, that were highly endorsed. Second, new data were collected (n = 219, age 60 and older, 52% female) with the 30-item RFL-OA and measures of depression, hopelessness, suicidal ideation, religiosity, health, and social desirability to examine the measure’s internal consistency and convergent and discriminant validity.

Results
Scores on the 30-item RFL-OA exhibited strong internal consistency. The short RFL-OA demonstrated good convergent validity via significant, moderate correlations with suicidal ideation, hopelessness, depression, and religiosity. It demonstrated adequate discriminant validity via only small correlations with disability, subjective health, and social desirability.

Discussion and Implications
The shorter RFL-OA has good psychometric properties among community-dwelling older adults. It may have greater utility, compared to the original 69-item measure, for clinicians and researchers with limited time but who want to assess protective factors against suicidal behavior in late life.
Collections of Orbits of Hyperplane Type in Homogeneous Spaces, Homogeneous Dynamics, and Hyperkähler Geometry
Authors: Amerik Ekaterina , Verbitsky Misha 
Published: January 2018

Abstract
Consider the space M = O(p, q)/O(p) × O(q) of positive p-dimensional subspaces in a pseudo-Euclidean space V of signature (p, q), where p &gt; 0, q &gt; 1 and $(p,q)\neq (1,2)$, with integral structure: $V = V_{\mathbb{Z}} \otimes \mathbb{Z}$. Let Γ be an arithmetic subgroup in $G = O(V_{\mathbb{Z}})$, and $R \subset V_{\mathbb{Z}}$ a Γ-invariant set of vectors with negative square. Denote by R⊥ the set of all positive p-planes W ⊂ V such that the orthogonal complement W⊥ contains some r ∈ R. We prove that either R⊥ is dense in M or Γ acts on R with finitely many orbits. This is used to prove that the squares of primitive classes giving the rational boundary of the Kähler cone (i.e., the classes of “negative” minimal rational curves) on a hyperkähler manifold X are bounded by a number which depends only on the deformation class of X. We also state and prove the density of orbits in a more general situation when M is the space of maximal compact subgroups in a simple real Lie group.