bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of Z chromosome divergence amongHeliconiusspecies highlight the importance of historical demography
Authors: Van Belleghem Steven M. , Baquero Margarita , Papa Riccardo , Salazar Camilo , McMillan W. Owen , Counterman Brian A. , Jiggins Chris D. , Martin Simon H. 
Published: November 2017

AbstractSex chromosomes are disproportionately involved in reproductive isolation and adaptation. In support of such a ‘large-X’ effect, genome scans between recently diverged populations or species pairs often identify distinct patterns of divergence on the sex chromosome compared to autosomes. When measures of divergence between populations are higher on the sex chromosome compared to autosomes, such patterns could be interpreted as evidence for faster divergence on the sex chromosome, i.e. ‘faster-X’, or barriers to gene flow on the sex chromosome. However, demographic changes can strongly skew divergence estimates and are not always taken into consideration. We used 224 whole genome sequences representing 36 populations from twoHeliconiusbutterfly clades (H. eratoandH. melpomene) to explore patterns of Z chromosome divergence. We show that increased divergence compared to equilibrium expectations can in many cases be explained by demographic change. AmongHeliconius eratopopulations, for instance, population size increase in the ancestral population can explain increased absolute divergence measures on the Z chromosome compared to the autosomes, as a result of increased ancestral Z chromosome genetic diversity. Nonetheless, we do identify increased divergence on the Z chromosome relative to the autosomes in parapatric or sympatric species comparisons that imply post-zygotic reproductive barriers. Using simulations, we show that this is consistent with reduced gene flow on the Z chromosome, perhaps due to greater accumulation of species incompatibilities. Our work demonstrates the importance of constructing an appropriate demographic null model in order to interpret patterns of divergence on the Z chromosome, but nonetheless provides evidence to support the Z chromosome as a strong barrier to gene flow in incipientHeliconiusbutterfly species.
Peptidomimetic blockade of MYB in acute myeloid leukemia
Authors: Ramaswamy Kavitha , Forbes Lauren , Minuesa Gerard , Gindin Tatyana , Brown Fiona , Kharas Michael , Krivtsov Andrei , Armstrong Scott , Still Eric , de Stanchina Elisa , Knoechel Birgit , Koche Richard , Kentsis Alex 
Published: November 2017

ABSTRACTAberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, largely due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activation with CREB-binding protein (CBP)/P300 is required for the initiation and maintenance of a variety of acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. Using structure-guided molecular design, we developed a prototypical peptidomimetic inhibitor MYBMIM that interferes with the assembly of the molecular MYB:CBP/P300 complex at micromolar concentrations and rapidly accumulates in the nuclei of AML cells. We found that treatment of AML cells with MYBMIM, led to the displacement of the MYB:CBP/P300 complex in cells, displacement of MYB from oncogenic enhancers and promoters enriched for MYB binding sites, and downregulation of MYB-dependent gene expression, including of MYC and BCL2 oncogenes. Both human MLL-rearranged and non-rearranged AML cells, underwent mitochondrial apoptosis in response to MYBMIM treatment, which could be partially rescued by ectopic expression of BCL2. We observed that MYBMIM treatment impeded leukemia growth and extended survival of immunodeficient mice engrafted with primary patient-derived MLL-rearranged leukemia cells. These findings emphasize the exquisite dependence of human AML on MYB:CBP/P300 transcriptional dysregulation, and establish a pharmacologic approach for its therapeutic blockade.
Effect of substituted methyl group by phenyl group in pyridazine ring on the corrosion inhibition of mild steel in 1.0 M HCl
Authors: Nahle Ayssar , El-Hajjaji Fadoua , Ghazoui Abdeslam , Benchat Nour-Eddine , Taleb Mustapha , Saddik Rafik , Elaatiaoui Abdelmalik , Koudad Mohammed , Hammouti Belkheir 
Published: November 2017

PurposeThe purpose of this paper is to study the inhibition effect of (6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) on the corrosion of mild steel in acidic medium by gravimetric measurements, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS).Design/methodology/approachWeight loss measurements, potentiodynamic tests and EIS were performed during this study.Findings(6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) was found to be a very efficient inhibitor for mild steel in 1.0 M HCl solution, reaching about 85 per cent with inhibitor concentration 1.0 × 10-3 M at 303 K.Practical implications(6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) was found to play an important role in the corrosion inhibition of mild steel in acidic solution.Originality/valueThis paper is intended to be added to the family of pyridazine derivatives which are highly efficient inhibitors and can be used in the area of corrosion prevention and control.
Who commits? Who engages?
Authors: Sutherland John 
Published: November 2017

PurposeThe purpose of this paper is to address two questions: who commits? And who engages? For example, does an individual’s likelihood of committing/engaging vary with his/her age; or with the level of his/her qualifications; or with his/her occupation? Of what consequences are the characteristics of the workplace at which the individual is employed?Design/methodology/approachThe investigation uses the Skills and Employment Surveys Series Data set to construct the indicators of commitment and engagement. Using an ordered-logit model and an OLS model, these indicators are analysed to identify their covariates.FindingsWho commits and who engages depends upon the indicator used to measure the attitude/behaviour in question. Changing these indicators sometimes means that an individual no longer commits/engages. Further, even for the same indicator of commitment/engagement, who commits/engages varies across individuals.Research limitations/implicationsThe indicators of commitment and engagement examined are derived from the responses in a pre-existing data set which has its origins in survey instruments which had quite comprehensive terms of reference. Owning to the cross-sectional nature of this data set and the statistical methodology applied, the statistical results are correlations between some possible indicators of commitment and engagement and some variables which denote the personal characteristics of individuals and the characteristics of the organisations with which they are employed. Causation cannot be inferred from these correlations.Originality/valueCommitment and engagement are central to many models of the management of human resources. However, the likelihood that an individual commits and/or engages differs across the workforce has rarely been examined. This paper addresses this research lacuna using a data set which is rich in detail about an individual’s personal characteristics.
A comparative study of covariance and partial least squares based structural equation modelling in hospitality and tourism research
Authors: Ali Faizan , Kim Woo Gon , Li Jun (Justin) , Cobanoglu Cihan 
Published: November 2017

Purpose
Structural equation modelling (SEM) has increasingly been used by hospitality and tourism researchers to examine complex relationships. This paper aims to highlight the benefits and limitations of SEM for hospitality and tourism research and compare its two main approaches, i.e. covariance-based SEM (CB-SEM) and partial least squares-SEM (PLS-SEM).

Design/methodology/approach
By using a comparative approach, this study parallels SEM’s two main approaches, i.e. CB-SEM and PLS-SEM, using three different examples from hospitality and tourism industry. Both the approaches are compared side by side in terms of assumptions, validity and reliability of measurement models, item retention and loadings, strength and significance of path relationships and coefficient of determinations.

Findings
The findings show that even though both methods analyse measurement theory and structural path models, there are relatively higher advantages for hospitality and tourism researchers in applying PLS-SEM.

Research limitations/implications
Because of the limitations of only using three examples, the results and trends generated in this study may not be generalized to all research in hospitality and tourism discipline. Moreover, the Likert scale has been used to measure the constructs in both the studies, which may have biased the results.

Originality value
This study is the first to compare the usage of both the SEM approaches in hospitality and tourism research. The findings of this study provide significant implications and directions for hospitality and tourism researchers to apply PLS-SEM in the future.
Use of dynamic pricing strategies by Airbnb hosts
Authors: Gibbs Chris , Guttentag Daniel , Gretzel Ulrike , Yao Lan , Morton Jym 
Published: November 2017

Purpose
The purpose of this paper is to provide a comprehensive analysis of dynamic pricing by Airbnb hosts.

Design/methodology/approach
This study uses attribute and sales information from 39,837 Airbnb listings and hotel data from 1,025 hotels across five markets to test different hypotheses which explore the extent to which Airbnb hosts use dynamic pricing and how their pricing strategies compare to those of hotels.

Findings
Airbnb is a unique and complex platform in terms of dynamic pricing where hosts make limited use of dynamic pricing strategies, especially as compared to hotels. Notwithstanding their limited use, hosts who own listings in high-demand leisure markets, manage entire places, manage more listings and have more experience vary prices the most.

Practical implications
This study identified a great need for Airbnb to encourage dynamic pricing among its hosts, but also warned of the potential perils of dynamic pricing in the sharing economy context. The findings also demonstrated challenges for hotel managers interested in actionable information related to Airbnb as a competitor.

Originality/value
This is the first Airbnb study to use a comprehensive set of data over a continuous period in multiple markets to look at a number of listing and host factors and determine their relation with dynamic pricing strategies.
Ritualisation and money laundering in the Swiss banking sector
Authors: Carlin Aidan , Lokanan Mark Eshwar 
Published: November 2017

Purpose
This paper aims to highlight the relationship between money laundering and the patterns of behaviour evident throughout the larger structural environment of the Swiss banking sector. In particular, the paper used HSBC as a prototype case of structural ritualisation to show that the normalisation of corrupt, unethical behaviour in the banking environment has shaped and influenced the behaviour and actions of the embedded group actors.

Design/methodology/approach
The paper used a content analysis methodological approach of media sources to collect data. The content analysis was categorised into six core ritualised symbolic practices (RSP) categories – corruption, reputation, blame, ignorance, regret and criticism.

Findings
The findings reveal that the highly ranked RSPs involving corruption, reputation, blame, regret, ignorance and criticism influence the embedded group’s patterns of behaviour, and they formed part of the cognitive script that dictated their behaviour and actions in the Swiss banking sector.

Practical implications
The paper added to the calls by Swiss policymakers for amendments to Swiss bank secrecy laws to reflect the changing landscape of international banking and finance.

Originality/value
This is the first paper of its kind to study ritualised illegal practices related to money laundering in the Swiss banking sector.
Money laundering and predicate offenses: models of criminological and legal relationships
Authors: Rusanov Georgy , Pudovochkin Yury 
Published: November 2017

Purpose
Purpose of the study is to show the relationships of money laundering with predicate offenses.

Design/methodology/approach
Each of these groups of crimes was investigated against the following criteria: statistical data on convictions and the proportion of prisoners in the general structure of a criminal record, links to organized crime, methods of money laundering and proportion of laundered money received from a particular predicate offense in the total amount of money laundered.

Findings
Based on the study of Russian legislation and practice peculiarities of this relationship, the features of the following relationships were revealed: relationship between widespread and relatively easy-to-control crimes against the property and drug trafficking and high latent and more difficult-to-control corruption and economic crimes.

Originality/value
As a result, it was concluded that there is a potential connection between the public danger of money laundering, the degree of crime organization and efficiency of the process of money laundering depending on the type of a predicate offense.
A high gain 10 watts wideband distributed power amplifier for two way radio system
Authors: Sangaran Pragash , Kumar Narendra , Rajendran Jagadheswaran , Grebennikov Andrei 
Published: November 2017

Purpose
This paper aims to propose a practical design methodology of high-power wideband power amplifier.

Design/methodology/approach
The distributed power amplification method is used for a Gallium Nitride device to achieve wideband operation. To achieve the high power without trading-off the bandwidth and gain, a methodology to extract the package-loading effect is proposed and verified.

Findings
A maximum output power of 10 W is achieved from 100 MHz to 2 GHz with a wideband power gain of 32 dB in measurement. This performance is achieved through a single section matching network.

Research limitations/implications
Measurement accuracy is dependable to the thermal behaviour of the high-power device.

Practical implications
The proposed technique is an excellent solution to be used in the two way radio power amplifier that minimizes the fundamental trade-off issue between power, gain, bandwidth and efficiency.

Originality/value
In this work, a practical distributed power amplifier (DPA) design methodology is proposed that reduces the development cycle time for industrial engineers working on high-power circuit design application.
Quality of home life for adults with learning disabilities: the interplay of economic policy and professional practice
Authors: Dalrymple John 
Published: November 2017

Purpose
The purpose of this paper is to provide a commentary on the preceding article describing changing patterns in the provision and take-up of accommodation services for adults with learning disabilities in Ireland, in the context of the types of reductions in funding that have been apparent internationally for some time.

Design/methodology/approach
The commentary examines some of the implications and discusses some of the underlying quality of life issues implicit in the data presented. It also explores the tensions between owning one’s home and receiving specialist support and examines what supported living might enable services to achieve.

Findings
The paper concludes that the nature of economic policy and professional practice, alike, have implications for the quality of home life enjoyed by adults with learning disabilities; and that the interplay between them is more complex than is often allowed.

Originality/value
These issues are not new, but frustratingly enduring. Their fresh consideration might assist the urgent need to achieve a more coherent narrative capable of consistent application for present and future generations.
Speech deterioration in amyotrophic lateral sclerosis (ALS) after manifestation of bulbar symptoms
Authors: Makkonen Tanja , Ruottinen Hanna , Puhto Riitta , Helminen Mika , Palmio Johanna 
Published: November 2017

AbstractBackgroundThe symptoms and their progression in amyotrophic lateral sclerosis (ALS) are typically studied after the diagnosis has been confirmed. However, many people with ALS already have severe dysarthria and loss of adequate speech at the time of diagnosis. Speech‐and‐language therapy interventions should be targeted timely based on communicative need in ALS.AimsTo investigate how long natural speech will remain functional and to identify the changes in the speech of persons with ALS.Methods & ProceduresAltogether 30 consecutive participants were studied and divided into two groups based on the initial type of ALS, bulbar or spinal. Their speech disorder was evaluated on severity, articulation rate and intelligibility during the 2‐year follow‐up.Outcome & ResultsThe ability to speak deteriorated to poor and necessitated augmentative and alternative communication (AAC) methods with 60% of the participants. Their speech remained adequate on average for 18 months from the first bulbar symptom. Severity, articulation rate and intelligibility declined with nearly all participants during the study. To begin with speech deteriorated more in the bulbar group than in the spinal group and the difference remained during the whole follow‐up with some exceptions.Conclusions & ImplicationsThe onset of bulbar symptoms indicated the time to loss of speech better than when assessed from ALS diagnosis or the first speech therapy evaluation. In clinical work, it is important to take the initial type of ALS into consideration when determining the urgency of AAC measures as people with bulbar‐onset ALS are more susceptible to delayed evaluation and AAC intervention.
Nonlinear effect of irradiance on photoheterotrophic activity and growth of the aerobic anoxygenic phototrophic bacterium Dinoroseobacter shibae
Authors: Piwosz Kasia , Kaftan David , Dean Jason , Šetlík Jiří , Koblížek Michal 
Published: November 2017

SummaryAerobic anoxygenic photosynthetic bacteria are an important component of marine microbial communities. They produce energy in light using bacteriochlorophyll a containing photosystems. This extra energy provides an advantage over purely heterotrophic bacteria. One of the most intensively studied AAP bacteria is Dinoroseobacter shibae, a member of the environmentally important Roseobacter clade. Light stimulates its growth and metabolism, but the effect of light intensity remains unclear. Here, we show that an increase in biomass along an irradiance gradient followed the exponential rise to the maximum curve, with saturation at about 300 µmol photons m−2 s−1, without any inhibition at light intensities up to 600 µmol photons m−2 s−1. The cells adapted to higher irradiance by reducing pigmentation and increasing the electron transfer rate. This additional energy allowed D. shibae to redirect the metabolism of organic carbon sources such as glucose, leucine, glutamate, acetate and pyruvate toward anabolism, resulting in a twofold increase of their assimilation rates. We provide equations that can be feasibly incorporated into the existing model of D. shibae metabolism to further advance our understanding of the role of photoheterotrophy in the ocean.
Physician Practice Transitions to System Ownership Do Not Result in Diminished Practice Responsiveness to Patients
Authors: Poon Bing Ying , Shortell Stephen , Rodriguez Hector P. 
Published: November 2017

ObjectiveTo examine the extent to which physician‐to‐system ownership transitions are associated with declines in practice‐reported patient responsiveness (PRPR).Data SourcesA longitudinal cohort of practices (n = 897) from the National Survey of Large Physician Organizations/National Survey of Small‐ and Medium‐Sized Physician Organizations (2006/08) and the National Survey of All‐Size Physician Organizations (2012/13).Study DesignMultivariable regression estimated the effect of ownership on changes in PRPR, controlling for practice size, specialty composition, other practice, and market characteristics.Data Collection/Extraction MethodsData were collected from three nationally representative surveys of physician organizations consisting of 40‐minute interviews with the medical director, president, or chief executive officer.Principal FindingsNine percent of organizations transitioned to system ownership. Compared to practices that were continuously physician‐owned, practices that switched to system ownership did not have significantly lower PRPR at baseline but continuously system‐owned practices did. Transitions to system ownership were associated with increased PRPR compared to continuously physician ownership. Increased practice size and changes in specialty composition, however, were associated with diminished PRPR.ConclusionsPractices can maintain or improve strategies to address patient concerns when transferring ownership to systems with careful attention to the impact of increased size and changes in specialty composition.
Influence of socioeconomic factors and distance to radiotherapy on breast‐conserving surgery rates for early breast cancer in regional Australia; implications of change
Authors: Collins Ian M. , Lum Caroline , Versace Vincent L. 
Published: November 2017

AbstractAimsBreast conserving surgery rates are affected by many factors including distance to radiotherapy and tumor‐related features. Numerous studies have found women who must travel further for radiotherapy are more likely to choose mastectomy and avoid radiotherapy. We examined relationships between socioeconomic group, distance to radiotherapy services and mastectomy rates across a range of rural and metropolitan settings.MethodsWe used a dataset extracted from the Evaluation of Cancer Outcomes Barwon South Western Registry, which captured data on new breast cancer diagnoses in the southwest region of Victoria, Australia. Using logistic regression, we modeled treatment choice of women with early breast cancer (mastectomy vs breast conserving surgery) using explanatory variables that included distance to radiotherapy, and area‐level socioeconomic data from the Australian Bureau of Statistics, while controlling for clinical factors.ResultsMastectomy was associated with tumor size, nodal burden and younger age at surgery. Distance to a radiotherapy center was also strongly associated with increased rates of mastectomy for women who traveled 100–200 km for radiotherapy (odds ratio = 1.663; P = 0.03) compared to the reference group who were within 100 km of radiotherapy. No socioeconomic differences were seen between the two groups.ConclusionA strong association between distance to radiotherapy and the type of surgery for early breast cancer was found. Improving access to radiotherapy therefore has the potential to improve breast cancer outcomes for women in regional Australia.
Space Invaders in Barcelona: Political Society and Institutional Invention Beyond Representation
Authors: Salvini Francesco 
Published: November 2017

AbstractIn the contemporary neoliberal urban dynamics, those agencies that are on the margin of society constantly disrupt the boundaries of civil representation and forge new institutional relations within the dynamics of urban governance. I explore how this process was enacted at the turn of the century in Barcelona, looking at two coeval social mobilisations: the lock‐in of undocumented migrants in the Iglesia del Pi (2001), and the project of las agencias at the Museum of Contemporary Arts (1999–2003), both of which unfolded in the central neighbourhood of Raval. The invasion of the boundaries of civil society emerges here as a double phenomenon—one that develops both within society and in relation to institutions, instituting new modes of urban politics.