bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’économie égyptienne après la tourmente : les défis sont toujours là…
Authors: Lavergne Marc 
Published: July 2017

La promesse d’un retour à la paix sociale et à la prospérité, qui a fourni le prétexte à l’armée égyptienne pour reprendre le pouvoir en juillet 2013, n’a pas été tenue. Les maux de l’Egypte, qui avaient entraîné la chute de Hosni Moubarak, n’ont pas trouvé de solution : ils tiennent en effet à la nature même du système économique mis en place depuis la libéralisation ouverte par Anouar el Sadate dès les années 70. L’économie égyptienne repose depuis lors sur des rentes extérieures qui ont permis une croissance de la consommation, réservée à une minorité, mais n’ont pas été utilisées pour bâtir une économie durable et équilibrée. Le salut de l’Egypte ne proviendra pas des aides financières extérieures, ni des grands projets mirifiques qui ont la faveur de ses dirigeants, mais d’un retour d’un gouvernement légitime et compétent, dévolu à la fourniture de services publics, à la stimulation d’une économie productive et à un aménagement équilibré du territoire.
Dialogues Est-Ouest : les historiens économistes, la guerre froide et la détente
Authors: Berg Maxine 
Published: July 2017

À la fin des années 1950 apparut une nouvelle association internationale d’histoire, l’Association internationale d’histoire économique. Dès 1960, elle organisa une série de colloques d’importance qui réunirent des historiens issus de toute l’Europe, d’Union soviétique et d’Amérique du Nord, et aussi, en plus petit nombre, d’autres pays. L’association existe toujours ; ses congrès s’appellent aujourd’hui « congrès mondiaux », et ses participants sont très différents, ceux issus de l’ancien bloc de l’Est étant bien moins nombreux. L’association fut créée et maintenue à ses débuts en réponse à la Seconde Guerre mondiale et à la guerre froide. Cet article, qui s’appuie sur une méthodologie historique transnationale, étudie les collaborations européennes des débuts, surtout les contributions françaises et britanniques, le rôle des fondations philanthropiques américaines et des historiens économiques américains, et l’expérience soviétique et est-européenne. Il relate la façon dont l’organisation négocia un certain nombre de crises de la guerre froide, et dont les échanges intellectuels et personnels contribuèrent à éliminer d’anciens obstacles. La détermination d’un groupe d’historiens économiques à s’affranchir des divisions politiques révèle le terrain politique bien réel qu’occupèrent ces universitaires et intellectuels.
L’impossible déchéance de nationalité. L’État français face au volontariat militaire pro-carliste (1872-1876)
Authors: Dupont Alexandre 
Published: July 2017

Les récents débats sur la déchéance de nationalité ont remis au cœur de l’actualité une question qui s’était déjà posée pour les volontaires français partis se battre à l’étranger. L’État s’y était confronté au XIX e siècle et, tout en interdisant en droit, avait laissé faire en fait. Dans un cas cependant, celui des volontaires français pro-carlistes dans les années 1870, les autorités françaises ont semblé bien résolues à user de cette arme judiciaire, avant de devoir renoncer pour de multiples raisons. Le volontariat pro-carliste constitue donc un observatoire privilégié de l’extrême difficulté pour l’État d’appliquer réellement la déchéance de nationalité à des combattants internationaux.
Du contre-transfert traumatique au plaisir partagé
Authors: Pons Nicolas Sylvie 
Published: July 2017

À partir du modèle du jeu comme analogon du travail analytique, l’auteure s’intéresse aux moments de rupture de la transitionnalité dans la cure, lorsqu’un des protagonistes ne peut pas jouer. Cela nous confronte à des situations aux limites de l’analysable. Comment dès lors rétablir de la transitionnalité ? Quels sont les indices de sa présence ?
José Bleger : penser la psychanalyse
Authors: Bleger Leopoldo 
Published: July 2017

L’œuvre de J. Bleger, ainsi que celles d’autres psychanalystes du Río de la Plata (la rivière entre Buenos Aires et Montevideo), semble depuis déjà quelques années susciter un intérêt grandissant dans le monde psychanalytique francophone, ce dont témoigne un colloque récent à Genève (Silvia Amati-Sas, Marie-Claire Caloz-Tschopp et Valeria Wagner, 2016). Ce texte retrace certains aspects du parcours de J. Bleger, une pensée en débat, en le situant dans le contexte de la psychanalyse du Río de la Plata des années 50 aux années 70. Le texte aborde quatre concepts que J. Bleger a particulièrement travaillés : la séance psychanalytique, la symbiose, l’ambiguïté et la question du cadre psychanalytique.
The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages
Authors: Carson William F. , Cavassani Karen A. , Soares Elyara M. , Hirai Soichiro , Kittan Nicolai A. , Schaller Matthew A. , Scola Melissa M. , Joshi Amrita , Matsukawa Akihiro , Aronoff David M. , Johnson Craig N. , Dou Yali , Gallagher Katherine A. , Kunkel Steven L. 
Published: July 2017

Abstract
Macrophages are critical immune cells for the clearance of microbial pathogens and cellular debris from peripheral tissues. Macrophage inflammatory responses are governed by gene expression patterns, and these patterns are often subject to epigenetic control. Chromatin modifications, such as histone methylation, regulate gene accessibility in macrophages, and macrophage polarization is governed in part by the expression and function of chromatin-modifying enzymes. The histone methyltransferase mixed-lineage leukemia 1 (MLL1) preferentially modifies lysine residue 4 on the unstructured protein tail of histone H3. MLL1 expression and function have been shown to be governed by signal transduction pathways that are activated by inflammatory stimuli, such as NF-κB. Therefore, we sought to investigate the role of MLL1 in mediating macrophage inflammatory responses. Bone marrow–derived macrophages from mice with a targeted MLL1 gene knockout (Lys2-Cre+/− MLL1fx/fx) exhibited decreased proinflammatory gene expression with concurrent decreases in activating histone methylation. However, MLL1-deficient macrophages also exhibited increased phagocytic and bacterial killing activity in vitro. RNA profiling of MLL1-knockout macrophages identified numerous genes involved with inflammatory responses whose expression was altered in response to TLR ligands or proinflammatory cytokines, including STAT4. STAT4-dependent cytokines, such as type I IFNs were able to drive MLL1 expression in macrophages, and MLL1-knockout macrophages exhibited decreased activating histone methylation in the STAT4 promoter. These results implicate an important role for MLL1-dependent epigenetic regulation of macrophage antimicrobial functions.
IL-17 Promotes Differentiation of Splenic LSK− Lymphoid Progenitors into B Cells followingPlasmodium yoeliiInfection
Authors: Ghosh Debopam , Brown Susie L. , Stumhofer Jason S. 
Published: July 2017

AbstractLineage−Sca-1+c-Kit− (LSK−) cells are a lymphoid progenitor population that expands in the spleen and preferentially differentiates into mature B cells in response to Plasmodium yoelii infection in mice. Furthermore, LSK− derived B cells can subsequently contribute to the ongoing immune response through the generation of parasite-specific Ab-secreting cells, as well as germinal center and memory B cells. However, the factors that promote their differentiation into B cells in the spleen postinfection are not defined. In this article, we show that LSK− cells produce the cytokine IL-17 in response to Plasmodium infection. Using Il-17ra−/− mice, IL-17R signaling in cells other than LSK− cells was found to support their differentiation into B cells. Moreover, primary splenic stromal cells grown in the presence of IL-17 enhanced the production of CXCL12, a chemokine associated with B cell development in the bone marrow, by a population of IL-17RA–expressing podoplanin+CD31− stromal cells, a profile associated with fibroblastic reticular cells. Subsequent blockade of CXCL12 in vitro reduced differentiation of LSK− cells into B cells, supporting a direct role for this chemokine in this process. Immunofluorescence indicated that podoplanin+ stromal cells in the red pulp were the primary producers of CXCL12 after P. yoelii infection. Furthermore, podoplanin staining on stromal cells was more diffuse, and CXCL12 staining was dramatically reduced in Il-17ra−/− mice postinfection. Together, these results identify a distinct pathway that supports lymphoid development in the spleen during acute Plasmodium infection.
α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus–Infected Wounds
Authors: Falahee Patrick C. , Anderson Leif S. , Reynolds Mack B. , Pirir Mauricio , McLaughlin Bridget E. , Dillen Carly A. , Cheung Ambrose L. , Miller Lloyd S. , Simon Scott I. 
Published: July 2017

Abstract
The immune response to Staphylococcus aureus infection in skin involves the recruitment of polymorphonuclear neutrophils (PMNs) from the bone marrow via the circulation and local granulopoiesis from hematopoietic stem and progenitor cells (HSPCs) that also traffic to infected skin wounds. We focus on regulation of PMN number and function and the role of pore-forming α-toxin (AT), a virulence factor that causes host cell lysis and elicits inflammasome-mediated IL-1β secretion in wounds. Infection with wild-type S. aureus enriched in AT reduced PMN recruitment and resulted in sustained bacterial burden and delayed wound healing. In contrast, PMN recruitment to wounds infected with an isogenic AT-deficient S. aureus strain was unimpeded, exhibiting efficient bacterial clearance and hastened wound resolution. HSPCs recruited to infected wounds were unaffected by AT production and were activated to expand PMN numbers in proportion to S. aureus abundance in a manner regulated by TLR2 and IL-1R signaling. Immunodeficient MyD88-knockout mice infected with S. aureus experienced lethal sepsis that was reversed by PMN expansion mediated by injection of wild-type HSPCs directly into wounds. We conclude that AT-induced IL-1β promotes local granulopoiesis and effective resolution of S. aureus–infected wounds, revealing a potential antibiotic-free strategy for tuning the innate immune response to treat methicillin-resistant S. aureus infection in immunodeficient patients.
Física Moderna e técnicas computacionais: como "ver" o átomo de Hidrogênio
Authors: Da Silva Nelson Canzian 
Published: July 2017

http://dx.doi.org/10.5007/2175-7941.2016v33n2p667 Este artigo busca construir uma ligação entre dois temas que têm recebido cada vez mais atenção nos anos finais da educação básica e nos anos iniciais do ensino superior nas áreas de ciência e tecnologia: a introdução à física moderna e a introdução a técnicas básicas de programação. Como pretexto, o artigo descreve como gerar figuras que representam, através de um pontilhado ou uma escala de cores, as densidades de probabilidade para o elétron em um átomo de hidrogênio. Isso é feito apresentando brevemente a física do problema de base e comentando algoritmos que (a) implementam as equações do problema, (b) permitem gerar valores aleatórios a partir de distribuições de probabilidades arbitrárias e (c) efetivamente produzem as figuras. O objetivo fundamental é mostrar ao leitor como técnicas básicas de modelagem e visualização de dados são efetivamente implementadas utilizando um tema que em princípio é de seu interesse. A implementação é feita em HTML/CSS/JavaScript, uma tecnologia extremamente versátil e acessível que constitui a base de todo o conteúdo na internet hoje, incluindo muitos ambientes educacionais virtuais.
Resenha do livro “Schrödinger” de José Maria Filardo Bassalo e Francisco Caruso
Authors: Moreno Roberto Rivelino De M. 
Published: July 2017

http://dx.doi.org/10.5007/2175-7941.2016v33n2p735Editora Livraria da Física, São Paulo, 2015, 1a edição, 94 pISBN: 9788578613372
Resenha do livro “Aulas de Marie Curie: anotadas por Isabelle Chavannes em 1907”
Authors: Souza Graziela Ferreira de 
Published: July 2017

http://dx.doi.org/10.5007/2175-7941.2016v33n3p1161 Resenha do livro “Aulas de Marie Curie: anotadas por Isabelle Chavannes em 1907”Edusp: Editora da Universidade de São Paulo, São Paulo, 2007, 1. ed. 136p.ISBN: 978-85-314-1003-1
Effectiveness of Environment-Based Interventions That Address Behavior, Perception, and Falls in People With Alzheimer’s Disease and Related Major Neurocognitive Disorders: A Systematic Review
Authors: Jensen Lou , Padilla René 
Published: July 2017

Abstract
OBJECTIVE. This systematic review evaluated the effectiveness of environment-based interventions that address behavior, perception, and falls in the home and other settings for people with Alzheimer’s disease (AD) and related major neurocognitive disorders (NCDs).
METHOD. Database searches were limited to outcomes studies published in English in peer-reviewed journals between January 2006 and April 2014.
RESULTS. A total of 1,854 articles were initially identified, of which 42 met inclusion criteria.
CONCLUSION. Strong evidence indicates that person-centered approaches can improve behavior. Moderate evidence supports noise regulation, environmental design, unobtrusive visual barriers, and environmental relocation strategies to reduce problematic behaviors. Evidence is insufficient for the effectiveness of mealtime ambient music, bright light, proprioceptive input, wander gardens, optical strategies, and sensory devices in improving behavior or reducing wandering and falls. Although evidence supports many environment-based interventions used by occupational therapy practitioners to address behavior, perception, and falls in people with AD and related major NCDs, more studies are needed.
The Influence of Asset Structure, Capital Structure, Risk Management and Good Corporate Governance on Financial Performance and Value of The Firm through Earnings and Free Cash Flow As An Intervening Variable in Banking Companies Listed in Indonesia Stock Exchange
Authors: F. Ukhriyawati Catur , Ratnawati Tri , Riyadi Slamet 
Published: July 2017

Banking companies that have gone public has the goal of increasing prosperity of the owners or shareholders by increasing the value of the company. The value of the company is very important because of the high value of the company which will be followed by a high prosperity shareholders. This study aimed to analyze the influence of asset structure, capital structure, risk management and good corporate governance on financial performance and value of the firm through earnings and free cash flow as an intervening variable in banking companies listed in Indonesia Stock Exchange. Data analysis techniques use Partial Least Square (PLS) and from data processing and hypothesis testing, produced 13 accepted hypothesis and 8 hypothesis is rejected. The results of this study were (1) asset structure influence positive and significantly to earnings, (2) capital structure influence negative and significantly to earnings, (3) risk management influence positive and no significantly to earnings, (4) Good Corporate Governance influence positive and significantly to earnings, (5) asset structure influence positive and significantly to free cash flow, (6) capital structure influence positive and no significantly to free cash flow, (7) risk management influence negative and no significantly to free cash flow, (8) Good Corporate Governance influence positive and no significantly to free cash flow, (9) asset structure influence negative and no significantly to financial performance, (10) capital structure influence negative and significantly to financial performance, (11) risk management influence positive and no significantly to financial performance, (12) Good Corporate Governance influence positive and significantly to financial performance, (13) asset structure influence positive and significantly to value of the firm, (14) capital structure influence positive and no significantly to value of the firm, (15) risk management influence negative and significantly to value of the firm, (16 ) Good Corporate Governance influence positive and significantly to value of the firm, (17) earnings influence positive and significantly to financial performance, (18) free cash flow influence positive and significantly to financial performance, (19) earnings influence positive and significantly to value of the firm, (20) free cash flow influence positive and no significantly to value of the firm and (21) financial performance influence positive and significantly to value of the firm.
Alignment of adherence and risk for HIV acquisition in a demonstration project of pre‐exposure prophylaxis among HIV serodiscordant couples in Kenya and Uganda: a prospective analysis of prevention‐effective adherence
Authors: Haberer Jessica E. , Kidoguchi Lara , Heffron Renee , Mugo Nelly , Bukusi Elizabeth , Katabira Elly , Asiimwe Stephen , Thomas Katherine K. , Celum Connie , Baeten Jared M. 
Published: July 2017

AbstractIntroduction: Adherence is essential for pre‐exposure prophylaxis (PrEP) to protect against HIV acquisition, but PrEP use need not be life‐long. PrEP is most efficient when its use is aligned with periods of risk – a concept termed prevention‐effective adherence. The objective of this paper is to describe prevention‐effective adherence and predictors of adherence within an open‐label delivery project of integrated PrEP and antiretroviral therapy (ART) among HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project).Methods: We offered PrEP to HIV‐uninfected participants until the partner living with HIV had taken ART for ≥6 months (a strategy known as “PrEP as a bridge to ART”). The level of adherence sufficient to protect against HIV was estimated in two ways: ≥4 and ≥6 doses/week (per electronic monitoring). Risk for HIV acquisition was considered high if the couple reported sex with <100% condom use before six months of ART, low if they reported sex but had 100% condom use and/or six months of ART and very low if no sex was reported. We assessed prevention‐effective adherence by cross‐tabulating PrEP use with HIV risk and used multivariable regression models to assess predictors of ≥4 and ≥6 doses/week.Results: A total of 985 HIV‐uninfected participants initiated PrEP; 67% were male, median age was twenty‐nine years, and 67% reported condomless sex in the month before enrolment. An average of ≥4 doses and ≥6 doses/week were taken in 81% and 67% of participant‐visits, respectively. Adherence sufficient to protect against HIV acquisition was achieved in 75–88% of participant‐visits with high HIV risk. The strongest predictor of achieving sufficient adherence was reporting sex with the study partner who was living with HIV; other statistically significant predictors included no concerns about daily PrEP, pregnancy or pregnancy intention, females aged >25 years, older male partners and desire for relationship success. Predictors of not achieving sufficient adherence were no longer being a couple, delayed PrEP initiation, >6 months of follow‐up, ART use >6 months by the partner living with HIV and problem alcohol use.Conclusions: Over three‐quarters of participant‐visits by HIV‐uninfected partners in serodiscordant couples achieved prevention‐effective adherence with PrEP. Greater adherence was observed during months with HIV risk and the strongest predictor of achieving sufficient adherence was sexual activity.
Willingness to use HIV pre‐exposure prophylaxis among gay men, other men who have sex with men and transgender women in Myanmar
Authors: Draper Bridget L. , Oo Zaw Min , Thein Zaw Win , Aung Poe Poe , Veronese Vanessa , Ryan Claire , Thant Myo , Hughes Chad , Stoové Mark 
Published: July 2017

AbstractIntroduction: HIV pre‐exposure prophylaxis (PrEP) has emerged as a key component of contemporary HIV combination prevention strategies. To explore the local suitability of PrEP, country‐specific acceptability studies are needed to inform potential PrEP implementation. In the context of Myanmar, in addition to resource constraints, HIV service access by gay men, other men who have sex with men, and transgender women (GMT) continues to be constrained by legislative and community stigma and marginalization. We aimed to determine PrEP acceptability among GMT in Myanmar and explore the factors associated with willingness to use PrEP.Methods: GMT were recruited in Yangon and Mandalay through local HIV prevention outreach programmes in November and December 2014. Quantitative surveys were administered by trained peer educators and collected data on demographics, sexual risk, testing history and PrEP acceptability. A modified six‐item PrEP acceptability scale classified self‐reported HIV undiagnosed GMT as willing to use PrEP. Multivariable logistic regression identified factors associated with willingness to use PrEP.Results: Among 434 HIV undiagnosed GMT, PrEP awareness was low (5%). PrEP acceptability was high, with 270 (62%) GMT classified as willing to use PrEP. GMT recruited in Mandalay (adjusted odds ratio (aOR) = 1.79; 95%CI = 1.05–3.03), who perceived themselves as likely to become HIV positive (aOR = 1.82; 95%CI = 1.10–3.02), who had more than one recent regular partner (aOR = 2.94; 95%CI = 1.41–6.14), no regular partners (aOR = 2.05; 95%CI = 1.10–3.67), more than five casual partners (aOR = 2.05; 95%CI = 1.06–3.99) or no casual partners (aOR = 2.25; 95%CI = 1.23–4.11) were more likely to be willing to use PrEP. The association between never or only occasionally using condoms with casual partners and willingness to use PrEP was marginally significant (aOR = 2.02; 95%CI = 1.00–4.10). GMT who reported concern about side effects and long‐term use of PrEP were less likely (aOR = 0.35; 95%CI = 0.21–0.59) to be willing to use PrEP.Conclusions: This is the first study to assess PrEP acceptability in Myanmar. Findings suggest PrEP is an acceptable prevention option among GMT in Myanmar, providing they are not required to pay for it. Implementation/demonstration projects are needed to explore the feasibility and cost‐effectiveness of PrEP as a prevention option for GMT in Myanmar.
Physically driven patchy O2 changes in the North Atlantic Ocean simulated by the CMIP5 Earth system models
Authors: Tagklis F. , Bracco A. , Ito T. 
Published: July 2017

AbstractThe subpolar North Atlantic is a key region for the oceanic uptake of heat, oxygen, and carbon dioxide. Centennial oxygen (O2) changes are investigated in the upper 700 m of the North Atlantic Ocean using a subset of Earth system models (ESMs) included in the Coupled Model Intercomparison Project phase 5. The climatological distributions of dissolved O2 averaged for the recent past period (1975–2005) are generally well captured, although the convective activity differs among the models in space and strength, and most models show a cold bias south of Greenland. By the end of the twenty‐first century, all models predict an increase in depth‐integrated temperature of 2–3°C, resultant solubility decrease, weakened vertical mass transport, decreased nutrient supply into the euphotic layer, and weakened export production. Despite an overall tendency of the North Atlantic to lose oxygen, patchy regions of O2 increase are observed due to the weakening of the North Atlantic Current (NAC) causing a regional solubility increase (the warming hole effect) and a decrease in the advection of subtropical, low‐O2 waters into the subpolar regions (the nutrient stream effect). Additionally, a shift in the NAC position contributes to localized O2 changes near the boundaries of water masses. The net O2 change reflects the combination of multiple factors leading to highly heterogeneous and model‐dependent patterns. Our results imply that changes in the strength and position of the NAC will likely play crucial roles in setting the pattern of O2 changes in future projections.