bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life Expectancy Exploration of Heart Failure Patients Presenting with Diabetes
Authors: Narh Prosper , Ofosu Michael Asante , Addo Elliot Owusu , Preko Daniel Wiafe , Bart-Plange Grace Aba , Acquah Roselyn Oforiwaa 
Published: September 2024

ABSTRACTBackgroundDiabetes is a serious medical condition marked by high blood sugar levels, leading to complications in organs like the kidney, liver, and heart. Previous research has identified diabetes as a primary risk factor for congestive heart failure (CHF), a condition where stiffened heart muscles hinder oxygenated blood circulation. Despite its severity, few studies have examined CHF prognosis in diabetic patients. This study aims to provide survival estimates and provide their comparisons among predictors, assess mortality risks based on specific variables, and reveal patient outcome patterns.MethodsWe analyzed data from a 2015 study at Faisalabad Institute of Cardiology and Allied Hospital (FICAH), Pakistan, focusing on 125 diabetic patients with Class III or IV heart failure and left ventricular systolic dysfunction. Kaplan-Meier estimates provided survival rates, log-rank tests compared survival across variables, Cox regression models estimated hazard ratios, and cluster analysis grouped patients by characteristics and survival rates.ResultsThe study examined 125 diabetic heart failure patients. Of these, 40(32%) were censored and the remaining 85(68%) died. The total follow-up period was 278 days, on the 120thday, 0.752[95% CI = 0.678,0,883] of the patients survived after initial diagnosis. Log-rank tests showed survival differences linked to high blood pressure, anemia and smoking. Cox regression identified age, smoking and hypertension as major mortality risk factors. Cluster analysis revealed the risk factors associated with middle aged and the older patients.ConclusionThe overall prognosis of heart failure patients with diabetes was poor with high mortality rates, implying effective treatment and management.
Branched Oncolytic Peptides Target HSPGs, Inhibit Metastasis, and Trigger the Release of Molecular Determinants of Immunogenic Cell Death in Pancreatic Cancer
Authors: Rencinai Alessandro , Tollapi Eva , Marianantoni Giulia , Brunetti Jlenia , Henriquez Tania , Pini Alessandro , Bracci Luisa , Falciani Chiara 
Published: September 2024

ABSTRACTImmunogenic cell death (ICD) can be exploited to treat non-immunoreactive tumors that do not respond to current standard and innovative therapies. Not all chemotherapeutics trigger ICD, among those that do exert this effect, there are anthracyclines, irinotecan, some platinum derivatives and oncolytic peptides. We studied two new branched oncolytic peptides, BOP7 and BOP9 that proved to elicit the release of damage-associated molecular patterns DAMPS, mediators of ICD, in pancreatic cancer cells. The two BOPs selectively bound and killed tumor cells, particularly PANC-1 and Mia PaCa-2, but not cells of non-tumor origin such as RAW 264.7, CHO-K1 and pgsA-745. The cancer selectivity of the two BOPs may be attributed to their repeated cationic sequences, which enable multivalent binding to heparan sulfate glycosaminoglycans (HSPGs), bearing multiple anionic sulfation patterns on cancer cells. This interaction of BOPs with HSPGs not only fosters an anti-metastatic effectin vitro, as demonstrated by reduced adhesion and migration of PANC-1 cancer cells, but also shows promising tumor-specific cytotoxicity and low hemolytic activity. Remarkably, the cytotoxicity induced by BOPs triggers the release of DAMPs, particularly HMGB1, IFN-β and ATP, by dying cells, persisting longer than the cytotoxicity of conventional chemotherapeutic agents such as irinotecan and daunorubicin. Anin vivoassay in nude mice showed an encouraging 20% inhibition of tumor grafting and growth in a pancreatic cancer model by BOP9.
A multidimensional Pan-cancer analysis of CDKN1A identifies CDKN1A as an Immunological and Prognostic Biomarker
Authors: Zhang Wenyang , Ma Qinglong , Li Wenrun , Zhao Honghui , Zhong Linghui , Xiao Yinan , Ren Yaru , Yang Kaixin , Li Yonghong , Shi Lei 
Published: September 2024

AbstractCDKN1A/p21 is well recognized for its role in cell cycle regulation and genomic stability. However, its functions in the Tumor microenvironment (TME) and tumor immunity are not yet fully understood. Hereby, we explored CDKN1A expression and immunological/prognostic values via various databases and analytical methods including cBioPortal, Kaplan-Meier, UCSCXenaShiny, TIMER, Single-cell RNA sequencing (scRNA-seq) analysis, etc. In addition, we explored different approaches including CCK8, EdU, Colony formation, Drug sensitivity and Annixin-V assay to explore the influence of p21 in proliferative capacity in cancer cells. We found that CDKN1A is lowly expressed in BLCA, BRCA, COAD, KICH, LUAD, LUSC, PRAD, READ and STAD compared to normal samples, whereas it is highly expressed in CHOL, HNSC, KIRC, KIRP and THCA compared to normal cohorts. CDKN1A expression is significantly correlated with overall survival, disease-specific survival, disease-free survival and progression-free interval different cancer types. Additionally, CDKN1A is associated with CD4+ T cell, CD8+ T cell, Neutrophil, Macrophage and Myeloid dendritic cell infiltration in diverse cancer types. Functional experiments reveal that p21 overexpression leads to a significant reduction in proliferative capacity, facilitates cell apoptosis and senescence in multiple cancer cell lines. In contrast, silenced p21 facilitates cell growth and wound closure, prevent cell senescence in different cancer cell lines. In conclusion, our findings suggest that CDKN1A may serve as a valuable prognostic and immunotherapeutic marker in diverse cancer.
Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations
Authors: Singh Harinder , Wiscovitch-Russo Rosana , Kuelbs Claire , Espinoza Josh , Appel Amanda E. , Lyons Ruth J. , Vashee Sanjay , Förtsch Hagen E.A. , Foster Jerome E. , Ramdath Dan , Hayes Vanessa M. , Nelson Karen E. , Gonzalez-Juarbe Norberto 
Published: September 2024

AbstractSocieties with exposure to preindustrial diets exhibit improved markers of health. Our study used a comprehensive multi-omic approach to reveal that the gut microbiome of the Ju/’hoansi hunter-gatherers, one of the most remote KhoeSan groups, exhibit a higher diversity and richness, with an abundance of microbial species lost in the western population. The Ju/’hoansi microbiome showed enhanced global transcription and enrichment of complex carbohydrate metabolic and energy generation pathways. The Ju/’hoansi also show high abundance of short-chain fatty acids that are associated with health and optimal immune function. In contrast, these pathways and their respective species were found in low abundance or completely absent in Western populations. Amino acid and fatty acid metabolism pathways were observed prevalent in the Western population, associated with biomarkers of chronic inflammation. Our study provides the first in-depth multi-omic characterization of the Ju/’hoansi microbiome, revealing uncharacterized species and functional pathways that are associated with health.
General hydrodynamic approach for a cold Bose gas
Authors: Pergamenshchik V. M. 
Published: September 2024

The aim of this paper is to derive the hydrodynamics for a cold Bose gas from the microscopic platform based on the many-body Schrödinger equation and general assumptions of the hydrodynamic approach (HA) applicable to any dimension. We develop a general HA for a cold spatially inhomogeneous Bose gas assuming two different temporal and spatial scales and obtain the energy as a functional of both fast inner quantum mode and slow macroscopic mode. The equations governing the fast and slow modes are obtained from this functional by their independent variations. The fast mode is the wave function in the stationary state at local density which can be ground, excited with a nonzero atom momenta, or a superposition of more than one state. The energy eigenvalue (or expectation value) of this local wave function universally enters the hydrodynamic equation for the slow mode in the form of the local chemical potential which incorporates the inner local momentum. For zero inner momenta and particular choices of this eigenvalue as a function of gas density, this equation reduces to the known equations based on the local density approximation. If, however, the inner momenta are nonzero, the equation includes the interaction between these momenta and the slow mode velocity. Relation between this general HA and the standard local density approximation is elaborated. Two effects of the local momenta and their density dependence on the soliton solutions are demonstrated.

Published by the American Physical Society
2024
Phenomenological model for
γγ*→KK¯*(892)
constraining the
f1(1420)
transition form factor
Authors: Ren Xiu-Lei , Danilkin Igor , Vanderhaeghen Marc 
Published: September 2024

We present a phenomenological study of the γγ*→KK¯*(892) process by including the s-channel production of the η(1475) and f1(1420) resonances. The nonresonant channel via K- and K*-exchanges is investigated carefully by performing the Lorentz tensor decomposition and is constructed to yield a correct high-energy Regge behavior. The transition form factor of f1(1420) is adjusted to achieve a reasonable description of the existing L3 data in the f1(1420) resonance region. This model is intended to serve as a Monte Carlo generator for the analysis currently being performed by the BESIII Collaboration. We also estimate the polarized γγ*→KK¯*(892) cross sections and demonstrate how to extract the transition form factors of f1(1420) from the polarized cross sections.

Published by the American Physical Society
2024
Searching for Scalar Field Dark Matter with LIGO
Authors: Göttel Alexandre S. , Ejlli Aldo , Karan Kanioar , Vermeulen Sander M. , Aiello Lorenzo , Raymond Vivien , Grote Hartmut 
Published: September 2024

We report on a direct search for scalar field dark matter using data from LIGO’s third observing run. We analyze the coupling of size oscillations of the interferometer’s beam splitter and arm test masses that may be caused by scalar field dark matter. Using new efficient search methods to maximize sensitivity for signatures of such oscillations, we set new upper limits for the coupling constants of scalar field dark matter as a function of its mass, which improve upon bounds from previous direct searches by up to four orders of magnitude in a frequency band from 10 to 180 Hz.

Published by the American Physical Society
2024
Synthesis, crystal structure, magnetic behaviour and thermal stability of a paddle-wheel copper(II) complex bearing equatorial 3,4-diethoxybenzoate ligands
Authors: Bermúdez Mariano Marziali , Muller Federico G. , Baggio Ricardo , Cukiernik Fabio D. 
Published: September 2024

The binuclear paddle-wheel copper(II) complex tetrakis(μ-3,4-diethoxybenzoato-κ2
O:O′)bis[(ethanol-κO)copper(II)], [Cu2(C11H13O4)4(C2H6O)2], has been synthesized and characterized. In each molecule, two CuII centres are bridged in a syn–syn fashion by four equatorial 3,4-diethoxybenzoate ligands, the two axial positions being occupied by ethanol molecules. The thermal stability has been studied by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) techniques. The magnetic behaviour, studied by SQUID magnetometry, shows a CuII–CuII antiferromagnetic exchange interaction with 2J = −288 cm−1, a value that fits with a magnetic structure correlation established for compounds of this kind.
Authentic and laissez-faire leadership as drivers of employees well-being: the moderating role of resilience and self-efficacy
Authors: López-Cabarcos M. Ángeles , López-Carballeira Analía , Ferro-Soto Carlos 
Published: September 2024

PurposePublic police professionals must deal with complex and disruptive social, political and organizational environments. This fact highlights the key role that leadership can play in effectively managing their work, while also ensuring their well-being. The aim of this research is to analyze the influence of laissez-faire versus authentic leadership on the work engagement of police professionals, considering the mediating role of emotional exhaustion and the moderating role of resilience and self-efficacy.Design/methodology/approachStructural equation modeling and hierarchical multiple regression analysis were used in a sample of 184 public police professionals.FindingsThe results show that emotional exhaustion partially mediates the relationship between authentic leadership and work engagement, and fully mediates the relationship between laissez-faire leadership and work engagement. Moreover, resilience moderates the relationships between authentic leadership, emotional exhaustion and work engagement; and self-efficacy moderates the relationships between laissez-faire leadership and emotional exhaustion and between laissez-faire leadership and work engagement.Originality/valueThis study highlights that constructive leadership is an important driver of positive experiences at work; it is necessary to change from passive to constructive leadership; and it is important for the combination of psychological resources and positive leadership to improve police professionals’ well-being.
What makes the reconstruction of old residential buildings complex? A study in Vietnamese urban areas
Authors: Nguyen Minh Van , Ha Khanh Duy , Phan Chien Thanh 
Published: September 2024

PurposeReconstruction of old buildings is often necessary after prolonged usage, but these projects encounter various complexities, leading to their failure. However, there is a lack of studies that focus on investigating the complexity of old building reconstruction initiatives. Thus, this study aims to examine the complexity of reconstruction projects for old buildings in Vietnamese urban areas.Design/methodology/approachThrough a literature review and discussions with experienced practitioners, 12 significant complexity factors were identified. The study then utilized the fuzzy decision-making trial and evaluation laboratory (DEMATEL) technique to analyze the interrelationships among these complexity factors.FindingsThe findings revealed intricate interdependencies among the complexity factors, visualized in a complexity map. The map highlighted the critical complexities of site compensation, clearance and the long project duration. Furthermore, a causal diagram categorized the complexity factors into net-effect and net-cause groups.Originality/valueBy examining the relationships and interactions among these factors, the study emphasizes the interconnected nature of complex systems and the influence of one factor on others. Therefore, decision-makers and stakeholders involved in reconstructing old buildings are suggested to possess a comprehensive understanding of these interdependencies to ensure effective decision-making.
Analysis of the role players in wildlife trafficking and the measures to combat it in South Africa
Authors: Marais Elisma , McIntyre Jacqui-Lyn , Aslett Duane 
Published: September 2024

Purpose
Corruption is one of the main facilitators of increased wildlife crime in South Africa. It is important to look at the current legislative framework to determine how wildlife crime can be combated effectively. This paper aims to provide an analysis of the process of wildlife crime, focusing on wildlife poaching and trafficking role players and critically analyses the legislation in place to combat the phenomenon.

Design/methodology/approach
A critical analysis of existing literature such as case law, legislation, peer-reviewed publications and electronic articles was used to identify the legislation and processes for the prevention of wildlife crime in South Africa. Common denominators were identified in these sources to provide a baseline for examining wildlife crime.

Findings
Wildlife criminals rely extensively on corruption during all facets of their trafficking schemes. The use of traditional environmental laws is not effective in dismantling wildlife trafficking networks, as prosecuting those in the upper echelons is often challenging. The extensive reliance on corruption during all facets of wildlife trafficking provides an opportunity for law enforcement to use such corruption crimes as predicate offences in racketeering prosecutions, thus ensuring kingpins find it more difficult to escape prosecution, owing to their involvement in criminal enterprises that sustain themselves through patterns of racketeering.

Originality/value
This paper contributes knowledge to narrow the research gap with regard to wildlife criminals and how they function. It also addresses possibilities to improve prosecution and disrupt wildlife trafficking networks.
Impact of e-service innovation on e-service delivery, trust and loyalty: a study of Indian retail banking
Authors: Bhat Ishfaq Hussain , Gupta Shilpi 
Published: September 2024

Purpose
The purpose of this study is to examine the effect of innovation in e-service delivery on trust and loyalty of Indian customers in the banking sector.

Design/methodology/approach
The stated relationships were drawn on the grounded theories by developing a conceptual model. Purposive sampling technique was used to collect the data from 400 bank customers who were availing the e-innovation services.

Findings
The findings of the study reveal that e-service innovation has a direct impact on e-service delivery and trust. The existence of a positive relationship between e-service delivery, trust and loyalty in the banking sector of India has also been found.

Practical implications
The findings of the study would help the practitioners and experts in the related fields to understand and adopt the innovative management practices in financial services in developing country like India.

Originality/value
Continuous e-innovation can create a distinct competitive advantage and avert the risk of vanishing from the market. The study contributes in terms of e-service innovation and e-service delivery in the banking sector in India. The impact of e-service innovation on banking outcomes begins with e-service and trust, these factors positively influences e-service innovation. Furthermore, e-service innovation exerts a positive effect on e-service delivery, trust and loyalty, thereby improving organizational value.
Sovereign Bond Holdings, Bank Risk‐Taking, and Macroeconomic Shocks: Evidence From Vietnam
Authors: Huynh Japan 
Published: September 2024

ABSTRACTThis study examines whether the purchase of sovereign bonds leads to decreased bank risk and how this impact changes in worse macroeconomic conditions. For a broad picture of macroeconomic shocks, we concentrate on the dimensions of uncertainty (the cross‐sectional dispersion of shocks to bank‐level characteristics) and crises (the global financial crisis and the COVID‐19 contagion). An empirical examination of the Vietnamese banking sector between 2007 and 2021 shows that banks purchasing securities issued by the domestic government tend to have lower risk. However, this impact is relatively weak on average, varying with the measures of bank risk. Through subsample tests, we document that the impact of sovereign bond holdings on bank risk is shaped by banks with high‐risk‐weighted assets and low diversification. Further results designate that sovereign bond holdings are necessary for banks as such activities help significantly lower their risk exposure in periods of crisis and uncertainty. This finding remains robust to different measures of bank risk.
Foodservice strategies for reducing athlete illness at the Olympic and Paralympic Games
Authors: Dufour Angela C. , Pelly Fiona E. , Wright Hattie H. , Tweedie Judith 
Published: September 2024

AbstractAimIn 2021, infection control guidelines, including those specific to feeding environments, were introduced by the International Olympic and Paralympic Committees to reduce virus transmission at the Tokyo 2020 Summer and Beijing 2022 Winter games. This observational cross‐sectional study aimed to investigate caterers' compliance to these guidelines which included measures for personal hygiene, sanitisation, and physical distancing at these events.MethodsExpert sport dietitians attending Tokyo (n = 15) and Beijing (n = 7) games were surveyed to rate 11 COVID‐19 countermeasures as fully (100%), partially or non‐compliant at nine dining locations across both events. Descriptive analysis of each countermeasure based on observed compliance and location was conducted and reported as a proportion of the total responses. To better understand participant perspectives of the factors influencing compliance, open responses were systematically coded into themes and sub‐themes by researchers through content analysis. Themes generated from participant comments were categorised based on their relevance to specific countermeasures and locations to identify commonalities and disparities in participant experiences, perceptions, and observations.ResultsAll main dining halls at both events were observed as 100% compliant to countermeasures on more occasions compared with Tokyo's venues and satellite villages. However, Beijing's three main dining halls, showed a greater compliance compared with Tokyo's main dining hall, likely due to overcrowding in Tokyo. Comments suggested that smaller dining spaces, with overcrowding, may have contributed to reduced compliance to physical distancing measures. Food safety concerns were raised about gastrointestinal distress in Beijing due to food cross‐contamination.ConclusionFindings suggest that the food service environment may influence caterers' abilities to comply with foodservice safety and infection control guidelines. In the post‐pandemic era, enhanced quality control and standardised risk mitigation strategies are needed to improve athletes' health at international sporting events.
Systematic review of interventions aimed at improving the quality of referrals to radiology
Authors: Tsang Chi Lap Nicholas , Luong David , Stapleton Troy 
Published: September 2024

SummaryDespite ubiquitous use of medical imaging in daily medical practice, the quality of referrals varies significantly across a variety of practice types and locations. This systematic review summarises studies in the literature that have employed interventions aimed at improving radiology referrals, excluding clinical decision support software. A systematic review of literature was conducted in PubMed, EMBASE, Scopus, and Cochrane. Two reviewers independently identified studies for inclusion. All studies that included interventions with any outcome measure were included. Any irrelevant studies, non‐English studies or not retrievable studies were excluded. Studies were grouped into Education, Feedback, Rationing, Penalties, and Other. The outcomes of the studies were summarised and qualitatively analysed due to anticipated heterogeneity. Four thousand six hundred and forty‐two studies were identified throughout PubMed, EMBASE, Scopus, and Cochrane. One hundred and eighty‐seven duplicates were removed and 4436 abstracts were screened. Two hundred and forty were identified on the first phase of the screening with 167 then excluded for non‐relevancy. Seventy‐five full studies were included in the final analysis following the addition of 2 additional studies. Fifty‐seven studies were grouped into Education, 10 into Feedback, 4 into Rationing, 8 into Penalties, 9 into Other and 11 containing multiple. Eighty‐four percent of the studies reported an improvement in the quality of the referrals. Despite a variable rate of quality referrals, there are many interventions that radiology departments across the world can utilise to improve the referral process.