bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Museum of Everyday Life: Objects and Affects of Glorious Obscurity
Authors: Levine Gabriel 
Published: December 2015

Abstract
Since 2011, the Museum of Everyday Life in Glover, Vermont, has existed as a ‘utopian homemade museum’ housed in a century-old barn. Guided by its curator, the museum draws from collectors, artists and friends to present exhibitions dedicated to ordinary mass-produced objects, often transformed in vernacular fashion. This article contextualizes and analyses the museum’s affective staging of everyday materiality. Drawing on affect theory and object-oriented thought, it examines three aspects of the museum’s practice: the everyday objects it presents and transforms, its playful strategies of display, and the wider networks that link it to pressing political and aesthetic concerns.
Book Reviews
Authors: Cooley Alison , Aggarwal-Schifellite Manisha 
Published: December 2015

Abstract
RADICAL MUSEOLOGY: OR, WHAT’S ‘CONTEMPORARY’ IN MUSEUMS OF CONTEMPORARY ART?, CLAIRE BISHOP AND DAN PERJOVSCHI Köln: Walther König (2014), 80 pp., Paperback, ISBN: 978-3-86335-364-3, US $19.95
MUSEUMS AND MIGRATION: HISTORY, MEMORY AND POLITICS, LAURENCE GOURIÉVIDIS (ED.) New York: Routledge (2014), 278 pp., Paperback, ISBN: 978-0-415-83876-4, $51.95
Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides
Authors: Challis Benjamin G , Albrechtsen Nicolai J Wewer , Bansiya Vishakha , Burling Keith , Barker Peter , Hartmann Bolette , Gribble Fiona , O'Rahilly Stephen , Holst Jens J , Simpson Helen L 
Published: December 2015

Summary
Pancreatic neuroendocrine tumours (pNETs) secreting proglucagon are associated with phenotypic heterogeneity. Here, we describe two patients with pNETs and varied clinical phenotypes due to differential processing and secretion of proglucagon-derived peptides (PGDPs). Case 1, a 57-year-old woman presented with necrolytic migratory erythema, anorexia, constipation and hyperinsulinaemic hypoglycaemia. She was found to have a grade 1 pNET, small bowel mucosal thickening and hyperglucagonaemia. Somatostatin analogue (SSA) therapy improved appetite, abolished hypoglycaemia and improved the rash. Case 2, a 48-year-old male presented with diabetes mellitus, diarrhoea, weight loss, nausea, vomiting and perineal rash due to a grade 1 metastatic pNET and hyperglucagonaemia. In both cases, plasma levels of all measured PGDPs were elevated and attenuated following SSA therapy. In case 1, there was increased production of intact glucagon-like peptide 1 (GLP-1) and GLP-2, similar to that of the enteroendocrine L cell. In case 2, pancreatic glucagon was elevated due to a pancreatic α-cell-like proglucagon processing profile. In summary, we describe two patients with pNETs and heterogeneous clinical phenotypes due to differential processing and secretion of PGDPs. This is the first description of a patient with symptomatic hyperinsulinaemic hypoglycaemia and marked gastrointestinal dysfunction due to, in part, a proglucagon-expressing pNET.

Learning points

PGDPs exhibit a diverse range of biological activities including critical roles in glucose and amino acid metabolism, energy homeostasis and gastrointestinal physiology.

The clinical manifestations of proglucagon-expressing tumours may exhibit marked phenotypic variation due to the biochemical heterogeneity of their secreted peptide repertoire.

Specific and precise biochemical assessment of individuals with proglucagon-expressing tumours may provide opportunities for improved diagnosis and clinical management.
Effects of DNA Methylation and Chromatin State on Rates of Molecular Evolution in Insects
Authors: Glastad Karl M , Goodisman Michael A D , Yi Soojin V , Hunt Brendan G 
Published: December 2015

Abstract
Epigenetic information is widely appreciated for its role in gene regulation in eukaryotic organisms. However, epigenetic information can also influence genome evolution. Here, we investigate the effects of epigenetic information on gene sequence evolution in two disparate insects: the fly Drosophila melanogaster, which lacks substantial DNA methylation, and the ant Camponotus floridanus, which possesses a functional DNA methylation system. We found that DNA methylation was positively correlated with the synonymous substitution rate in C. floridanus, suggesting a key effect of DNA methylation on patterns of gene evolution. However, our data suggest the link between DNA methylation and elevated rates of synonymous substitution was explained, in large part, by the targeting of DNA methylation to genes with signatures of transcriptionally active chromatin, rather than the mutational effect of DNA methylation itself. This phenomenon may be explained by an elevated mutation rate for genes residing in transcriptionally active chromatin, or by increased structural constraints on genes in inactive chromatin. This result highlights the importance of chromatin structure as the primary epigenetic driver of genome evolution in insects. Overall, our study demonstrates how different epigenetic systems contribute to variation in the rates of coding sequence evolution.
FASTmC: A Suite of Predictive Models for Nonreference-Based Estimations of DNA Methylation
Authors: Bewick Adam J , Hofmeister Brigitte T , Lee Kevin , Zhang Xiaoyu , Hall David W , Schmitz Robert J 
Published: December 2015

Abstract
We describe a suite of predictive models, coined FASTmC, for nonreference, cost-effective exploration and comparative analysis of context-specific DNA methylation levels. Accurate estimations of true DNA methylation levels can be obtained from as few as several thousand short-reads generated from whole-genome bisulfite sequencing. These models make high-resolution time course or developmental and large diversity studies practical regardless of species, genome size, and availability of a reference genome.
Back to Acid Soil Fields: The Citrate Transporter SbMATE Is a Major Asset for Sustainable Grain Yield for Sorghum Cultivated on Acid Soils
Authors: Carvalho Geraldo , Schaffert Robert Eugene , Malosetti Marcos , Viana Joao Herbert Moreira , Menezes Cicero Bezerra , Silva Lidianne Assis , Guimaraes Claudia Teixeira , Coelho Antonio Marcos , Kochian Leon V , van Eeuwijk Fred A , Magalhaes Jurandir Vieira 
Published: December 2015

AbstractAluminum (Al) toxicity damages plant roots and limits crop production on acid soils, which comprise up to 50% of the world’s arable lands. A major Al tolerance locus on chromosome 3, AltSB, controls aluminum tolerance in sorghum [Sorghum bicolor (L.) Moench] via SbMATE, an Al-activated plasma membrane transporter that mediates Al exclusion from sensitive regions in the root apex. As is the case with other known Al tolerance genes, SbMATE was cloned based on studies conducted under controlled environmental conditions, in nutrient solution. Therefore, its impact on grain yield on acid soils remains undetermined. To determine the real world impact of SbMATE, multi-trait quantitative trait loci (QTL) mapping in hydroponics, and, in the field, revealed a large-effect QTL colocalized with the Al tolerance locus AltSB, where SbMATE lies, conferring a 0.6 ton ha–1 grain yield increase on acid soils. A second QTL for Al tolerance in hydroponics, where the positive allele was also donated by the Al tolerant parent, SC283, was found on chromosome 9, indicating the presence of distinct Al tolerance genes in the sorghum genome, or genes acting in the SbMATE pathway leading to Al-activated citrate release. There was no yield penalty for AltSB, consistent with the highly localized Al regulated SbMATE expression in the root tip, and Al-dependent transport activity. A female effect of 0.5 ton ha–1 independently demonstrated the effectiveness of AltSB in hybrids. Al tolerance conferred by AltSB is thus an indispensable asset for sorghum production and food security on acid soils, many of which are located in developing countries.
Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network inSaccharomyces cerevisiae
Authors: Worley Jeremy , Sullivan Arron , Luo Xiangxia , Kaplan Matthew E , Capaldi Andrew P 
Published: December 2015

AbstractThe Target of Rapamycin kinase Complex I (TORC1) is a master regulator of cell growth and metabolism in eukaryotes. Studies in yeast and human cells have shown that nitrogen/amino acid starvation signals act through Npr2/Npr3 and the small GTPases Gtr1/Gtr2 (Rags in humans) to inhibit TORC1. However, it is unclear how other stress and starvation stimuli inhibit TORC1, and/or act in parallel with the TORC1 pathway, to control cell growth. To help answer these questions, we developed a novel automated pipeline and used it to measure the expression of a TORC1-dependent ribosome biogenesis gene (NSR1) during osmotic stress in 4700 Saccharomyces cerevisiae strains from the yeast knock-out collection. This led to the identification of 440 strains with significant and reproducible defects in NSR1 repression. The cell growth control and stress response proteins deleted in these strains form a highly connected network, including 56 proteins involved in vesicle trafficking and vacuolar function; 53 proteins that act downstream of TORC1 according to a rapamycin assay—including components of the HDAC Rpd3L, Elongator, and the INO80, CAF-1 and SWI/SNF chromatin remodeling complexes; over 100 proteins involved in signaling and metabolism; and 17 proteins that directly interact with TORC1. These data provide an important resource for labs studying cell growth control and stress signaling, and demonstrate the utility of our new, and easily adaptable, method for mapping gene regulatory networks.
DSM-5 criteria for gambling disorder: Underlying structure and applicability to specific groups of gamblers
Authors: Sleczka Pawel , Braun Barbara , Piontek Daniela , Bühringer Gerhard , Kraus Ludwig 
Published: December 2015

Background and Aims
DSM-5 provides nine diagnostic criteria for gambling disorder. All criteria have a pre-assumed equal diagnostic impact and are applied to all individuals and groups in an equal manner. The aims of the study are to analyse the structure underlying the diagnosis and to assess whether DSM-5 is equally applicable to different groups of gamblers.

Methods
Data from the 2009 German Epidemiological Survey of Substance Abuse and from a study on slot machine gamblers were used. Item Response Theory analysis was applied to estimate discrimination and severity parameters of the criteria. With the use of Differential Item Functioning analysis, potential criterion biases were analysed. We analysed data from 107 participants from the general population sample and 376 participants from the slot machine gamblers’ sample who answered a 19-item diagnostic questionnaire based on the DSM criteria for gambling disorder.

Results
A single underlying factor, the severity of gambling disorder, was identified in both samples. In the general population sample the criteria of preoccupation and chasing were least severe and showed low discriminatory power. Bailout, withdrawal and jeopardized matters criteria had highest severity and discriminatory power. The comparison of the two samples revealed two criterion biases in the preoccupation and tolerance criteria.

Conclusions
The structure underlying the criteria is unidimensional but the disorder is manifested differently depending on disorder severity. The assumed equal impact of each criterion lacks support in the findings. The DSM-5 criteria measure a partially different construct in slot machine gamblers than in gamblers in the general population.
Self-concept clarity and compulsive Internet use: The role of preference for virtual interactions and employment status in British and North-American samples
Authors: Quinones Cristina , Kakabadse Nada Korak 
Published: December 2015

Background and Aims
Compulsive Internet Use (CIU) describes a maladaptive relationship with the Internet characterised by loss of control and conflict. Although also affecting adults, most studies use teenage samples, and theoretical development on risk factors is scarce. According to Davis (2001), the social connectivity function of the Internet is key in identifying traits associated with CIU. Since Self-Concept Clarity (SCC) is strongly related to social anxiety, and virtual interactions allow “self-edition”, we hypothesized that individuals low in SCC could choose virtual interactions as safer alternative to satisfy their social needs. This could in turn increase the risk of CIU. Building on a previous study, we also expected CIU to be more harmful in the unemployed.

Methods
We collected samples from the UK (N = 532) and US (N = 502) with equal distribution of employed and unemployed individuals. We ran Measurement Invariance tests to confirm that the constructs were equivalent across countries. Subsequently, we conducted mediation and moderation analysis to test our hypothesis with Multigroup Confirmatory Factor Analysis.

Results
Measurement Invariance was confirmed. The relationship between SCC and CIU was partially mediated by preference of virtual interactions in both countries. This preference was significantly related to lower social support. Short term unemployment seemed to accentuate the negative impact of CIU on life satisfaction in both countries, although only marginally significantly in the US. The unemployed reported significantly lower levels of life satisfaction.

Conclusion
We demonstrated that SCC is a key vulnerability factor to CIU in adults, and confirmed the additional risks for the unemployed.
Think twice: Impulsivity and decision making in obsessive–compulsive disorder
Authors: Grassi Giacomo , Pallanti Stefano , Righi Lorenzo , Figee Martijn , Mantione Mariska , Denys Damiaan , Piccagliani Daniele , Rossi Alessandro , Stratta Paolo 
Published: December 2015

Background and Aims
Recent studies have challenged the anxiety-avoidance model of obsessive–compulsive disorder (OCD), linking OCD to impulsivity, risky-decision-making and reward-system dysfunction, which can also be found in addiction and might support the conceptualization of OCD as a behavioral addiction. Here, we conducted an exploratory investigation of the behavioral addiction model of OCD by assessing whether OCD patients are more impulsive, have impaired decision-making, and biased probabilistic reasoning, three core dimensions of addiction, in a sample of OCD patients and healthy controls.

Methods
We assessed these dimensions on 38 OCD patients and 39 healthy controls with the Barratt Impulsiveness Scale (BIS-11), the Iowa Gambling Task (IGT) and the Beads Task.

Results
OCD patients had significantly higher BIS-11 scores than controls, in particular on the cognitive subscales. They performed significantly worse than controls on the IGT preferring immediate reward despite negative future consequences, and did not learn from losses. Finally, OCD patients demonstrated biased probabilistic reasoning as reflected by significantly fewer draws to decision than controls on the Beads Task.

Conclusions
OCD patients are more impulsive than controls and demonstrate risky decision-making and biased probabilistic reasoning. These results might suggest that other conceptualizations of OCD, such as the behavioral addiction model, may be more suitable than the anxiety-avoidance one. However, further studies directly comparing OCD and behavioral addiction patients are needed in order to scrutinize this model.
La controverse éthique des bienveillantes : Réflexions sur la rationalité du bourreau
Authors: Jansen Lisanne 
Published: December 2015

À sa publication, les Bienveillantes de Jonathan Littell a suscité une violente controverse que l’on pourrait qualifier non sans raison d’éthique. La raison ? Une question de point de vue, une façon de mettre en scène la Shoah. Nous proposons ici d’interroger les ressorts de cette immoralité manifeste et de montrer comment la controverse attachée au roman de Littell intervient comme un dispositif capable de mettre à nu les conditions de possibilité d’une atrocité historique. Cette réflexion sur la rationalité du bourreau témoigne précisément d’un souci moral.
La ética del cuidado, sustento de la bioética enfermera
Authors: García Moyano Loreto María , Pellicer García Begoña , Arrazola Alberdi Oihana 
Published: December 2015

<p class="Standard">En la actualidad, la enfermería ha sabido reconocer la importancia de las exigencias éticas que vinculan al acto del cuidado, y así ha dado razón a los diferentes conflictos de valores a los que los profesionales hacen frente a diario. No obstante, la profesión, no ha sabido encontrar un modelo bioético único que englobe todos los aspectos que surgen de su quehacer profesional y que ayudaría a aumentar la calidad de los servicios de salud percibida, para humanizar así la acción profesional del cuidado. El presente trabajo pretende, mediante la discusión teórica y el método de comparación constante, demostrar la necesidad de la profesión enfermera de conocer los distintos modelos bioéticos, y en especial la llamada “ética del cuidado”, modelo impulsado en 1982 por la psicóloga y filósofa norteamericana Carol Gilligan, que podría servir como sustento para definir un modelo bioético enfermero concreto. De la misma manera, se pretende explicar la diferencia entre la ética del cuidado y la ética de los cuidados. </p>
Percepción del cuidado de enfermería dado a los pacientes con cáncer hospitalizados
Authors: Santamaría Narda Patricia , García Lilia Esperanza , Sánchez Herrera Beatriz , Carrillo Gloria Mabel 
Published: December 2015

<p>El objetivo principal de este artículo es describir el estado del arte sobre la percepción del cuidado de enfermería a pacientes oncológicos hospitalizados. Para esto, se hizo una revisión integrativa realizada en 16 bases de datos entre 1994 y 2014, teniendo en cuenta los descriptores percepción, relación enfermero-paciente, hospitalización y oncología, con sus respectivas traducciones al inglés y orientada por el descriptor boleano AND. Se encontraron de esta manera 52 publicaciones sobre la relación enfermera-paciente oncológico hospitalizado; asimismo, se evidenció que estas han ido en incremento, particularmente en la última década. La mayor parte de las publicaciones son de tipo cualitativo, revisiones o reflexiones. Al revisar en conjunto la productividad académica, se identificaron múltiples formas de abordar esta relación desde el punto de vista conceptual; sin embargo, parece ser su condición de reciprocidad la que resulta más enriquecedora para las partes, lo que permite que los sujetos que intercambian en medio del cuidado de la vida cuando se tiene un cáncer crezcan como personas y ganen en introspección. Así pues, la relación enfermera-paciente con cáncer hospitalizado es un punto central para poder comprender y cualificar las prácticas de cuidado de esta población. Se hace necesario desarrollar estrategias de medición y cualificación de esta interacción. </p>
Consideraciones bioéticas del tamizaje neonatal: pautas para su regulación integral
Authors: Cifuentes Ricardo 
Published: December 2015

<p>El tamizaje neonatal pretende detectar al nacimiento anomalías susceptibles de tratamiento antes de la aparición de enfermedad. Su objetivo es evitar discapacidad e incluso la muerte de algunos recién nacidos. Con los desarrollos tecnológicos los beneficios se han extendido a la familia y a la sociedad. Contrariamente, también se han documentado daños psicológicos, sociales e incluso físicos. La probabilidad de daño está influenciada por consideraciones asociadas con principios bioéticos como la confidencialidad,<em> </em>la cual se relaciona con los principios de dignidad y autonomía. Aparecen entonces controversias como el tiempo de retención de muestras. De forma similar, hay otras controversias asociadas a consideraciones bioéticas como la prioridad de la persona o el consentimiento. A pesar del panorama descrito, la legislación no aborda de forma integral las consideraciones bioéticas. Colombia no es la excepción; la normatividad específica para tamizaje neonatal no considera ni siquiera de forma aislada consideraciones fundamentales en este tópico. En este contexto, el <em>derecho blando</em> da directivas como el deber de garantizar el acceso o las circunstancias en las cuales es posible realizar el tamizaje neonatal sin beneficio directo para el neonato. Sin embargo, no aborda otras consideraciones como el consentimiento y la confidencialidad, lo que amerita un debate bioético integral.</p>
Atención bioética de la vulnerabilidad de los autistas: la odontología en la estrategia de salud de la familia
Authors: Amaral Lais David , Fabiano de Carvalho Talita , Barreto Bezerra Ana Cristina 
Published: December 2015

<p>El objetivo de este artículo es describir y discutir el enfoque y la intervención odontológica en autistas, así como la participación de la familia y de los profesionales de la salud oral en este contexto. Se cree que los principios de atención básica de la salud oral pueden ser aplicados en autistas y se sugiere un protocolo de atención odontológica al autista, dirigido a la práctica en los servicios de salud pública. Por tanto, son necesarios nuevos cuestionamientos enfocados a elevar la calidad de la atención odontológica al paciente autista, sobre todo en el Sistema Único de Salud y particularmente en la Estrategia de Salud de la Familia, en la atención de esta población vulnerable, con un enfoque bioético.</p>
Health Literacy, Pedometer, and Self-Reported Walking Among Older Adults
Authors: Al Sayah Fatima , Johnson Steven T. , Vallance Jeff 
Published: December 2015

Objectives. We examined the association of health literacy with physical activity and physical activity guideline adherence in older adults. Methods. We used cross-sectional data from a 2012 population-based study in Alberta, Canada, assessing health literacy, and deriving moderate-to-vigorous physical activity (MVPA) and metabolic equivalent of task (MET) minutes per week from the Godin Leisure-Time Exercise Questionnaire, and steps per day via a pedometer. Results. Mean age of participants (n = 1296) was 66.4 (SD = 8.2) years, 57% were female, and 94% were White. Nine percent had inadequate health literacy, and 46% met guidelines for self-reported physical activity and 18% for steps per day. Participants with inadequate health literacy had nonsignificant adjusted decrements of 58 MVPA minutes and 218 MET minutes per week and were less likely to meet physical activity guidelines (MVPA: odds ratio = 0.63; 95% confidence interval [CI] = 0.41, 0.97; P = .037; MET: odds ratio = 0.65; 95% CI = 0.42, 1.01; P = .057) compared with their health-literate counterparts. Such differences were nonsignificant for steps per day. Conclusions. Inadequate health literacy was associated with less likelihood of meeting MVPA guidelines based on self-reported physical activity, but not based on an objective measure of steps per day.
Adverse Childhood Experiences Related to Poor Adult Health Among Lesbian, Gay, and Bisexual Individuals
Authors: Austin Anna , Herrick Harry , Proescholdbell Scott 
Published: December 2015

Objectives. We explored the association of sexual orientation with poor adult health outcomes before and after adjustment for exposure to adverse childhood experiences (ACEs). Methods. Data were from the 2012 North Carolina, 2011 Washington, and 2011 and 2012 Wisconsin Behavioral Risk Factor Surveillance System (BRFSS) surveys regarding health risks, perceived poor health, and chronic conditions by sexual orientation and 8 categories of ACEs. There were 711 lesbian, gay, and bisexual (LGB) respondents and 29 690 heterosexual respondents. Results. LGB individuals had a higher prevalence of all ACEs than heterosexuals, with odds ratios ranging from 1.4 to 3.1. After adjustment for cumulative exposure to ACEs, sexual orientation was no longer associated with poor physical health, current smoking, and binge drinking. Associations with poor mental health, activity limitation, HIV risk behaviors, current asthma, depression, and disability remained, but were attenuated. Conclusions. The higher prevalence of ACEs among LGB individuals may account for some of their excess risk for poor adult health outcomes.