bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protección del empleo temporal y crecimiento de la productividad en economías de la UE
Authors: DAMIANI Mirella , POMPEI Fabrizio , RICCI Andrea 
Published: April 2017

ResumenEl objetivo principal de este artículo es determinar en qué medida la legislación de protección del empleo temporal afectó a la productividad total de los factores (TFP) en 14 países europeos y diez sectores de 1995 a 2007, mediante estimaciones de diferencias en diferencias. Según los resultados, la desreglamentación del empleo temporal afectó negativamente al crecimiento de la TFP en estas economías, así como en los sectores con mayor propensión al empleo temporal. Además, se observa que la desreglamentación del empleo temporal desalienta la formación y la adquisición de competencias específicas de la empresa, lo cual afecta a su vez a la productividad.
Developing a guideline for structured content and process in mental health nursing handover
Authors: Cowan Darrin , Brunero Scott , Luo Xiaoou , Bilton Dean , Lamont Scott 
Published: April 2017

AbstractThe process of handover has received recent attention within Australian health care, as evidence linking patient safety with the quality of handover emerges. Such links between clinical handover and patient safety have been reported elsewhere in the literature, where it is posited that the safe care of patients relies not only on the expertise and judgment of individual clinicians, teamwork, and effective management, but hinges to a large extent on the quality of information transferred from team to team. The present qualitative, descriptive study used participant observations, focus groups, and interviews to investigate the nursing handover in two acute mental health inpatient units in New South Wales, Australia. Data collected as part of that investigation contributed to the development of a handover guideline that incorporates the key components of structure, content, and leadership. The research indicated a link between these components, and further revealed the necessity to have other forums, such as supervision and clinical review, to ensure that handover serves its intended purpose in an efficient manner.
A theory‐informed qualitative exploration of social and environmental determinants of physical activity and dietary choices in adolescents with intellectual disabilities in their final year of school
Authors: Stevens Gemma , Jahoda Andrew , Matthews Lynsay , Hankey Catherine , Melville Craig , Murray Heather , Mitchell Fiona 
Published: April 2017

BackgroundThe prevalence of obesity is higher in those with intellectual disabilities than the general population. The aim of the study was to understand the determinants of physical activity and dietary patterns in this population during their final year of school.MethodQualitative data were generated from 10 interviews with adolescents with mild–moderate intellectual disabilities. Data were analysed using deductive thematic analysis, employing Self‐Determination Theory as a theoretical framework.ResultsAdolescents’ environment and social interactions play a pivotal role in influencing physical activity and dietary patterns. Three themes emerged from the analysis: situatedness, motivation and wider environmental influences.ConclusionsSchool structure, high self‐efficacy and social connectedness facilitate increased physical activity and healthier diet in adolescents with intellectual disabilities. Home life, low self‐efficacy and a lack of social connectedness can serve as a barrier to PA and a healthy diet.
Whoever shouts the loudest: Listening to parents of children with disabilities
Authors: Ryan Christian , Quinlan Elizabeth 
Published: April 2017

BackgroundElevated stress is common among parents of children with disabilities. The parents’ perspective and evaluation of services have a significant impact on their well‐being and adaptation to their child's disability and is a source of information for service improvements. This study explores parental perceptions of communication and collaboration between parents and health and education staff in the context of an imminent reconfiguration of disability services.MethodsA qualitative study was conducted using four focus groups with parents (n = 24) of children with disabilities who attend various educational and health services.ResultsThematic analysis revealed five key themes: Us versus them, lack of child/family centeredness, resources, keyworker and uncertain access to a complex system.ConclusionsParents want greater collaboration between parents and professionals. They identified a keyworker as a potential solution to the current system that is not child‐centred. This would also lessen the burden associated with high levels of advocacy.
Stock‐bond return co‐movement and accounting information
Authors: Cascino Stefano 
Published: April 2017

AbstractI examine how an important attribute of financial reporting quality, i.e., accounting conservatism, affects the sensitivity of corporate bond returns to changes in the value of equity (i.e., the hedge ratio). The correlation between stock and bond returns (co‐movement) is a fundamental input for asset allocation decisions as it determines the diversification benefits of bonds relative to equities within an investment portfolio. According to structural models of credit risk, co‐movement should be generally positive, but lower when the risk of wealth transfers from bondholders to shareholders is severe. I find that firms that report conservative earnings and use covenants in their bond contracts exhibit on average stronger co‐movement. This result is consistent with conservatism providing bondholders with a credible and contractible signal that improves monitoring, thus preventing wealth transfers.
A new metric to assess the predictive accuracy of multinomial land cover models
Authors: Douma Jacob C. , Cornwell William K. , van Bodegom Peter M. 
Published: April 2017

AbstractAimThe earth's land cover is often represented by discrete classes, and predicting shifts between these classes is a major goal in the field. One increasingly common approach is to build models that predict land cover classes with probabilities rather than discrete outcomes. Current assessment approaches have drawbacks when applied to these types of models. In this paper we present a new metric, which assesses agreement between model predictions and observations, while correcting for chance agreement.LocationGlobal.Methods is the product of two metrics: the first component measures the agreement in the ranks of the predicted and observed classes, the other specifies the certainty of the model in the case of discrete observations. We analysed the behaviour of and two alternative metrics: Cohen's Kappa () and an extension of the area under receiver operating characteristic Curve to multiple classes (mAUC) when applied to multinomial predictions and discrete observations.ResultsUsing real and synthetic datasets, we show that – in contrast to – can distinguish between models that are very far off versus slightly off. In addition, κmultinomial ranks models higher that predict observed classes with an onaverage higher probability. In contrast, mAUC gives the same score to models that are perfectly able to discriminate among classes of outcomes regardless of the certainty with which those classes are predicted.Main conclusionsWith we have provided a tool that directly uses the multinomial probabilities for accuracy assessment. may also be applied to cases where model predictions are evaluated against multiple sets of observations, at multiple spatial scales, or compared to reference models. As models develop we assess how well new models perform compared to the real world.
MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro
Authors: Yao Weifeng , Li Haobo , Han Xue , Chen Chaojin , Zhang Yihan , Tai Wai Lydia , Xia Zhengyuan , Hei Ziqing 
Published: April 2017

AbstractHepatic ischaemia/reperfusion (HIR) induces severe damage on hepatocyte cell membrane, which leads to hepatocyte death and the subsequent HIR injury. In this study, we investigated the role and the mechanism of mitsugumin‐53 (MG53), a novel cell membrane repair protein, in protecting the liver against HIR injury. Rats were subjected to sham operation or 70% warm HIR with or without recombined MG53 (rhMG53), caudal vein‐injected 2 hrs before inducing HIR. In vitro, cultured hepatocyte AML12 cells were subjected to hypoxia/reoxygenation (H/R) in the presence of rhMG53 and/or dysferlin gene shRNAs or adenovirus transfection. HIR resulted in severe liver injury manifested as severe liver histological changes and increased AST and ALT release. Post‐ischaemic hepatic oxidative stress was significantly enhanced demonstrated by elevated dihydroethidium level, increased 4‐hydroxynonenal, enhanced 15‐F2t‐isoprostane and decreased SOD activity. rhMG53 administration attenuated post‐HIR liver injury, decreased liver oxidative stress and further enhanced dysferlin protein expression and its colocalization with MG53. Similarly, H/R induced AML12 cell injury and oxidative stress, which were abolished by either rhMG53 or dysferlin overexpression but were exacerbated by dysferlin gene knockdown. Dysferlin overexpression further increased H/R‐induced increased colocalization of MG53 and dysferlin. In conclusion, MG53 was anchored by dysferlin to reduce oxidative stress and cell death and attenuate HIR injury.
Cyclic peptide *CRRETAWAC* attenuates fibronectin‐induced cytokine secretion of human airway smooth muscle cells by inhibiting FAK and p38 MAPK
Authors: Chu Mengdi , Ji Jiani , Cao Wenhao , Zhang Huojun , Meng Dan , Xie Bangruan , Xu Shuyun 
Published: April 2017

Abstractα5β1 integrin is highly expressed in airway smooth muscle cells and mediate the adhesion of airway smooth muscle cells to fibronectin to regulate airway remodelling in asthma. This study aimed to investigate the effects of synthetic cyclic peptide *CRRETAWAC* on fibronectin‐induced cytokine secretion of airway smooth muscle cells and the underlying mechanism. Human airway smooth muscle cells were isolated and treated with fibronectin, IL‐13, *CRRETAWAC* peptide, α5β1 integrin‐blocking antibody, FAK inhibitor or p38 MAPK inhibitor. The transcription and secretion of eotaxin‐1 and RANTES were detected by real‐time PCR and ELISA, respectively. The phosphorylation of FAK and MAPKs including p38, ERK1/2 and JNK1/2 was detected by Western blot analysis. The transcription and secretion of eotaxin‐1 and RANTES increased in airway smooth muscle cells cultured in fibronectin‐coated plates. However, α5β1 integrin‐blocking antibody, *CRRETAWAC* peptide, FAK inhibitor or p38 MAPK inhibitor significantly reduced mRNA levels and the secretion of eotaxin‐1 and RANTES in airway smooth muscle cells cultured in fibronectin‐coated plates. In addition, the phosphorylation of FAK and p38 MAPK was significantly increased in airway smooth muscle cells cultured in fibronectin‐coated plates compared to the cells cultured in uncoated plates and was significantly reduced in airway smooth muscle cells treated with *CRRETAWAC* peptide. Fibronectin induces cytokine synthesis and secretion of airway smooth muscle cells. Peptide *CRRETAWAC* antagonizes fibronectin‐induced cytokine synthesis and secretion of airway smooth muscle cells via the inhibition of FAK and p38 MAPK, and is a potential agent for the therapy of asthma.
Successful retreatment with combined BRAF/MEK inhibition in metastatic BRAFV600‐mutated melanoma
Authors: Amann V.C. , Hoffmann D. , Mangana J. , Dummer R. , Goldinger S.M. 
Published: April 2017

AbstractBackgroundThe combination treatment with BRAF and MEK inhibitors is amongst the current standard of care for stage IIIC/IV BRAF‐mutated melanoma. However, therapeutic options are limited once patients have progressed upon both targeted and immunotherapy.ObjectiveTo investigate whether retreatment with BRAF and MEK inhibitor combination is an option for patients with metastatic BRAF‐mutated melanoma upon previous progression on kinase inhibitors.MethodsTwo patients with metastatic BRAF‐mutated melanoma were rechallenged with BRAF and MEK inhibitor combination after progression on targeted therapy and subsequent immunotherapy with anti‐CTLA‐4 and anti‐PD‐1 antibodies.ResultsBoth patients responded to retreatment. Responses were limited to a few months and associated with a considerable increase in quality of life.ConclusionRetreatment with BRAF and MEK inhibitors may present a feasible treatment option upon progression on both kinase inhibitors and immunotherapy, and should be considered when all other treatment options have been exhausted.
Assessment of a short hypnosis in a paediatric operating room in reducing postoperative pain and anxiety: A randomised study
Authors: Duparc‐Alegria Nathalie , Tiberghien Karine , Abdoul Hendy , Dahmani Souhayl , Alberti Corinne , Thiollier Anne‐Francoise 
Published: April 2017

Aims and objectivesTo assess the impact of a short hypnotic session on postoperative anxiety and pain in major orthopaedic surgery.BackgroundDespite specific information given before a scheduled paediatric surgery, perioperative anxiety can become important.DesignRandomised Clinical Study.MethodsThe study is an open single‐centre randomised clinical study comparing a “control” group versus a “hypnosis” group receiving a short hypnosis pre‐induction session as additional experimental analgesic procedure. The primary endpoint was the postoperative anxiety, blindly assessed using a visual analogue scale.ResultsThe study involved 120 children (age 10–18 years). The results showed no difference between control group versus hypnosis group. Twenty‐four hours after surgery (Day+1), the patient's anxiety score was not different between control and hypnosis groups (median [Q1–Q3]: 1 [0; 3] vs. 0 [0; 3], respectively, p = .17). Each group experienced a significant decrease in anxiety level between the day before surgery (Day−1) and the day after surgery (Day+1) (median ([Q1–Q3]) difference of the anxiety score: 2 [4; 0] and 2 [4; 0], respectively, p < .0001 in each group). The postoperative pain scores were low and not different between groups (median [Q1–Q3]: 2 [0; 3] in control group vs. 3 [1; 3] in hypnosis group, p = .57).ConclusionThis randomised study on a short hypnosis session performed in the operating room prior to a major surgery showed no difference in postoperative anxiety and pain levels. The decrease in anxiety and pain levels may be due to the addition of nurse pre‐operative interviews and optimisation in communication in the operating room.Relevance to clinical practiceAs postoperative anxiety level was low in both control and hypnosis groups, nurse pre‐operative interviews and nurse training in hypnosis may contribute to the optimisation of global management and decrease the postoperative anxiety level.
Putting knowledge to work in clinical practice: Understanding experiences of preceptorship as outcomes of interconnected domains of learning
Authors: Allan Helen Therese , Magnusson Carin , Evans Karen , Horton Khim , Curtis Kathy , Ball Elaine , Johnson Martin 
Published: April 2017

Aims and objectivesTo explore how preceptor support can assist newly qualified nurses to put knowledge to work across interconnected forms of knowledge when delegating to healthcare assistants.BackgroundCurrent literature on preceptorship in nursing has failed to explore how competence is underpinned by knowledge frameworks in clinical practice.DesignAn ethnographic case study in three hospital sites in England (2011–2014).MethodsData collection included participant observation, interviews with 33 newly qualified nurses, 10 healthcare assistants and 12 ward managers. Data were analysed using thematic analysis. A tool to assist newly qualified nurses to delegate and supervise newly qualified nurses during the preceptorship period was developed and piloted with thirteen newly qualified nurses in the same sites. A process evaluation was undertaken.FindingsFocusing on a key task for newly qualified nurses, delegation to healthcare assistants, we argue that preceptorship can support newly qualified nurses as they put knowledge to work in the transition from qualifying student to newly qualified nurses. In supportive ward cultures, limited access to formal preceptorship can be bolstered by team support. newly qualified nurses in less supportive ward cultures may have both a greater need for preceptorship and fewer compensatory mechanisms available to them when formal preceptorship is not available. We argue that organisational learning contexts and individual learning styles (interconnected domains of learning) are key to understanding effective preceptorship.ConclusionsWe suggest that putting knowledge to work early in their careers with preceptorship support may assist newly qualified nurses to develop confidence and competence in delegation and supervision of healthcare assistants.Relevance to clinical practiceOur findings suggest that newly qualified nurses need to be supported by effective preceptorship in their learning as they transition from undergraduate to post graduate. Preceptorship programmes at ward and organisational level need to recognise the intensity of the learning required during this transition phase.
Retail Financial Advice: Does One Size Fit All?
Authors: FOERSTER STEPHEN , LINNAINMAA JUHANI T. , MELZER BRIAN T. , PREVITERO ALESSANDRO 
Published: April 2017

ABSTRACTUsing unique data on Canadian households, we show that financial advisors exert substantial influence over their clients' asset allocation, but provide limited customization. Advisor fixed effects explain considerably more variation in portfolio risk and home bias than a broad set of investor attributes that includes risk tolerance, age, investment horizon, and financial sophistication. Advisor effects remain important even when controlling flexibly for unobserved heterogeneity through investor fixed effects. An advisor's own asset allocation strongly predicts the allocations chosen on clients' behalf. This one‐size‐fits‐all advice does not come cheap: advised portfolios cost 2.5% per year, or 1.5% more than life cycle funds.
Precautionary Investment in Wealth and Health
Authors: Liu Desu , Menegatti Mario 
Published: April 2017

AbstractThis article studies how health and wealth investments react to the presence of random returns, distinguishing the case where only the level of health investment is chosen from the case where both health and wealth investments are chosen. We show that this reaction depends mainly on certain features of preferences: cross‐prudence/imprudence in wealth, cross‐prudence/imprudence in health, and the value of the indexes of relative prudence in wealth and in health being larger or smaller than the threshold of 2. We also show the role of Edgeworth–Pareto substitutability/complementarity between wealth and health investments in determining optimal choices.
Arnica montana L. – a plant of healing: review
Authors: Kriplani Priyanka , Guarve Kumar , Baghael Uttam S 
Published: April 2017

Abstract

Objectives
Arnica montana is a widely used therapeutic plant used traditionally to treat various ailments. The objective of this study was to evaluate the botany, phytochemistry and ethnopharmacology along with special emphasis given on pharmacological activity of plant A. montana.

Key findings
The plant extracts have been reported to possess antibacterial, antitumor, antioxidant, anti-inflammatory, antifungal and immunomodulatory activity. A wide range of chemical compounds including sesquiterpene lactones and their short-chain carbonic acid esters, flavonoids, carotenoids, essential oils, diterpenes, arnidiol, pyrrolizidine alkaloids, coumarins, phenolic acids, lignans and oligosaccharides, etc., are found in different parts of the plant.

Summary
It has been scrutinized that extensive research has been carried out to explore the therapeutic potential of flowers of the plant. Therefore, investigations should be carried out to explore the therapeutic potential of other parts of the plant for better therapeutic utilization.
Cyanomargarita gen. nov. (Nostocales, Cyanobacteria): convergent evolution resulting in a cryptic genus
Authors: Shalygin Sergei , Shalygina Regina , Johansen Jeffrey R. , Pietrasiak Nicole , Berrendero Gómez Esther , Bohunická Markéta , Mareš Jan , Sheil Christopher A. 
Published: April 2017

Two populations of Rivularia‐like cyanobacteria were isolated from ecologically distinct and biogeographically distant sites. One population was from an unpolluted stream in the Kola Peninsula of Russia, whereas the other was from a wet wall in the Grand Staircase‐Escalante National Monument, a desert park‐land in Utah. Though both were virtually indistinguishable from Rivularia in field and cultured material, they were both phylogenetically distant from Rivularia and the Rivulariaceae based on both 16S rRNA and rbcLX phylogenies. We here name the new cryptic genus Cyanomargarita gen. nov., with type species C. melechinii sp. nov., and additional species C. calcarea sp. nov. We also name a new family for these taxa, the Cyanomargaritaceae.
Confirmatory factor analysis of the Sleep Disturbance Scale for Children (SDSC) in a clinical sample of children and adolescents
Authors: Marriner Angela M. , Pestell Carmela , Bayliss Donna M. , McCann Marie , Bucks Romola S. 
Published: April 2017

SummaryThe Sleep Disturbance Scale for Children was developed as a parent‐report measure to screen for sleep disturbances within the preceding 6 months. Notably, the scale was developed using a sample of typically developing children and children with sleep disorders. The aim of this study was to factor analyse the Sleep Disturbance Scale for Children using a clinical sample of children with a range of neuropsychological conditions and co‐morbidities, and determine whether the original six‐factor structure was retained. Four‐hundred and sixteen children aged 5–17 years were assessed at the Neurosciences Unit (Perth, Western Australia) as part of routine, clinical neuropsychological assessment. Parents and guardians also completed the Sleep Disturbance Scale for Children to rate their child's sleep. Confirmatory factor analysis of the original Sleep Disturbance Scale for Children model (Bruni et al. J. Sleep Res., 1996, 5: 251–261) revealed a less than ideal fit. Three adjustments were made to the model based on factor loadings and modification indices. The sleep hyperhidrosis factor (including items 9 and 16) along with item 10 was removed, leaving a five‐factor Sleep Disturbance Scale for Children model. The five‐factor model (Sleep Disturbance Scale for Children‐R) was factor analysed, and examination of model fit statistics indicated that this new model produced good fit. Additional analyses revealed that older children had greater difficulty falling and staying asleep, and with daytime sleepiness. However, no significant differences were observed across gender, diagnosis or socioeconomic status. The results of this study suggest that the Sleep Disturbance Scale for Children‐R may be a more appropriate measure when assessing clinical samples. However, further research is required to validate the Sleep Disturbance Scale for Children‐R against objective measures of sleep and to determine appropriate t‐score cut‐offs.