bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADHD-pain: Characteristics of chronic pain and association with muscular dysregulation in adults with ADHD
Authors: Udal Anne Beate Helseth , Stray Liv Larsen , Stray Torstein , Bertelsen Thomas Bjerregaard , Pripp Are Hugo , Egeland Jens 
Published: September 2024

Abstract

Objectives
A high incidence of attention-deficit hyperactivity disorder (ADHD) has been reported in chronic pain (ChP) patients. Furthermore, an association between ChP and muscular dysregulation has been reported in adults with ADHD. The present study investigated whether ADHD was more prevalent among psychiatric outpatients with ChP than those without ChP, and if there was an association between ChP, muscular dysregulation and characteristics of pain in patients with ADHD.

Methods
One-hundred and twenty-one individuals remitted to an outpatient psychiatry unit took part in this naturalistic epidemiological cross-sectional study. They were assessed with a pain self-report form (localization, intensity, and onset) and a test of muscle dysregulation (the Motor Function Neurological Assessment). Prevalence of ADHD among patients with ChP, as well as the qualitative characteristics of ChP within the ADHDgroup are reported. Both ChP and pain intensity correlated with muscular dysregulation through Spearman’s rho analysis. Additionally, the relationship between various diagnostic categories (ADHD, affective disorders, anxiety, or personality disorders) and incidence of axial pain was evaluated in logistic regression.

Results
ADHD was significantly more prevalent in patients with ChP, than in patients without ChP. In the ADHD group, ChP and pain intensity was associated with muscular dysregulation, particularly with high muscle tone. ChP was more axial and widespread, than for the patients without ADHD, and started at an early age. ADHD diagnosis predicted axial pain, whereas affective-, anxiety-, or personality disorders did not.

Conclusions
The study suggests that ChP in ADHD is associated with muscular dysregulation and is qualitatively different from ChP in psychiatric patients without ADHD. These findings may lead to further understanding of potential mechanisms involved in ADHD and ChP, and in turn to new treatment strategies for both disorders.
Sevoﬂurane in the Acute Phase of Severe Traumatic Brain Injury
Authors: Safiullin D. R. , Cherpakov R. A. , Shabanov A. K. , Polyakov P. A. , Grebenchikov O. A. 
Published: September 2024

The aim of the study was to evaluate the usefulness and safety of sevoﬂurane in patients in the acute phase of severe traumatic brain injury (TBI).Materials and methods. A prospective, randomized, pilot clinical trial was conducted at the Sklifosovsky Research Institute for Emergency Medicine (Moscow) in adults with acute severe TBI, aged 18 years and older, undergoing intensive intracranial pressure (ICP)-guided therapy. To achieve the desired sedative eﬀect, the inhaled anesthetic sevoﬂurane was administered in the main group, and standard doses of intravenous propofol were administered in the control group. ICP and cerebral oxygen extraction fraction (OEF) were monitored in all patients. Hemodynamic and respiratory support parameters, transcranial Doppler ultrasound scan, brain bioelectrical activity, brain CT scan, laboratory parameters, markers of inﬂammation, patients' need for sedation and mechanical ventilation, and length of ICU stay were also evaluated.Results. The use of inhalation sedation contributed to the reduction of ICP on day 2 (9.5 mmHg in the sevoﬂurane group and 17.3 mmHg in the propofol group, P=0.003) and day 3 (10 mmHg and 14.2 mmHg, respectively, P=0.005). BIS monitoring showed no signiﬁcant diﬀerence in depth of sedation between groups on day 2 (60 vs. 48.5, P=0.070) and day 3 (61 vs. 46, P=0.095). Inhalation sedation reduced cerebral OEF on the injury side compared to propofol on day 2 (23.3 vs. 30.2%, P=0.006) and day 3 (22.7 vs. 31.2%, P<0.001). After 24 hours of sedation therapy, there was a signiﬁcant diﬀerence in P/F (PaO₂/FiO₂) ratios between the groups. On days 1, 3, and 7, the sevoﬂurane group had P/F ratios of 340, 324, and 323 mmHg, while the propofol group had signiﬁcantly lower ratios of 271, 278, and 275 mmHg (P<0.001). Pneumonia was documented in 9 cases in the sevoﬂurane group vs. 18 cases in the propofol group (P=0.028), and a similar trend was observed in the total number of infectious complications: 13 vs. 21 cases, respectively (P=0.046).Conclusion. Sevoﬂurane in the acute phase of severe TBI was not only safe, but also improved several vital functions, including ICP, blood pressure, P/F ratio, and also slowed brain metabolism via reduced oxygen consumption without aﬀecting the depth of sedation according to BIS monitoring data. All of the above suggests that inhalation sedation may improve the prognosis for patient recovery. However, multicenter randomized clinical trials are needed to identify and verify all positive and negative eﬀects of inhalation sedation in this patient population.
Integrating adaptive learning with post hoc model explanation and symbolic regression to build interpretable surrogate models
Authors: Biswas Ankita , Liu Shunshun , Garg Sunidhi , Morshed Md Golam , Vakili Hamed , Ghosh Avik W. , Balachandran Prasanna V. 
Published: September 2024

Abstract
We develop a materials informatics workflow to build an interpretable surrogate model for micromagnetic simulations. Our goal is to predict the energy barrier of a moving isolated skyrmion in rare-earth-free $$\hbox {Mn}_4$$

Mn
4

N. Our approach integrates adaptive learning with post hoc model explanation and symbolic regression methods. We discuss an unexplored acquisition function (information condensing active learning) within the adaptive learning loop and compare it with the known standard deviation function for efficient navigation of the search space. Model-agnostic post hoc explanation techniques then uncover trends learned by the trained model, which we then leverage to constrain the expressions used for symbolic regression.

Graphical abstract
Patrones de género y territoriales en la distribución del prestigio académico. El caso de los Premios Nacionales de la Academia de Ciencias de Cuba (2014-2023)
Authors: Fowler Berenguer Kenneth , Sánchez Rivero Rubén 
Published: September 2024

Objetivo: Analizar, a partir de una metodología cuantitativa, los patrones de género y territoriales en el conjunto de los trabajos reconocidos con los Premios Nacionales de la Academia de Ciencias de Cuba durante el periodo de 2014 a 2023.
Métodos: El conjunto de autores, y sus relaciones dentro de los grupos de firmantes de cada trabajo, se modelaron con una red de coautoría. Los autores se agruparon de acuerdo al sexo y la provincia de su filiación institucional, y se comparó el efecto de estas agrupaciones en la distribución de un indicador de centralidad, que fue empleado como estimador del prestigio autoral. Se comparó además el porcentaje de participación femenina por premio en cada una de las ramas de la ciencia.
Resultados: El análisis de la distribución del indicador de centralidad, reveló que, independientemente de la agrupación por sexos, los autores de la capital tienen un puntaje estadísticamente superior a sus contrapartes del resto del país. Se observó además que los patrones de participación femenina en cada rama de la ciencia son consistentes con las dinámicas de feminización y masculinización de las distintas disciplinas académicas en el país, que han sido evidenciadas por las estadísticas oficiales y por los resultados de otras investigaciones científicas.
Conclusiones: Los resultados obtenidos contribuyen a señalar las desigualdades en las dinámicas de participación en la ciencia, la tecnología y la innovación que persisten en el país; y como estas se reproducen a su vez en los espacios de mayor legitimación social de la actividad.
Significance of correcting magnesium deficiency in different groups of women in surgical menopause
Authors: Blinov D. V. , Gromova О. A. , Solopova A. G. , Ezhova A. A. , Kuznetsova A. S. , Kalashnikova I. S. , Bitsadze V. О. , Makatsariya A. D. 
Published: September 2024

Background. In the 21st century, there is a clear trend towards an increase in the proportion of women with climacteric syndrome (CS) and surgical menopause. Medical care for such patients usually includes menopausal hormone therapy (MHT), which often causes changes in magnesium and pyridoxine metabolism and their deficiency, leading to the development of adverse reactions. Therefore, it is necessary to improve rehabilitation programs designed to increаse the quality of life (QoL) for this category of gynecological patients.Objective: to assess the profile of women with CS and surgical menopause receiving and not receiving MHT and to identify the significance of magnesium deficiency (MD) effect on the recovery process.Material and methods. The observational non-interventional study included a total of 9168 women, of which 1528 patiеnts with CS and surgical menopause were taking MHT (Group 1), and 1528 patients with CS and surgical menopause were not taking MHT (Group 2). The Magnesium Deficiency Questionnaire (MDQ) was used to determine the number of participants with MD. A biochemical blood test was also performed, including determination of plasma magnesium concentration. The patients’ profile was analyzed for general somatic pathologies, obstetric and gynecological history, complaints, and MD symptoms using visual analogue scale. To assess QoL before the start of 4-week MD replenishing course and at the end of therapy, the World Health Organization Quality of Life Questionnaire (WHOQL-26) was applied.Results. The MDQ data showed that the prevalence of DM in Group 1 was higher compared to Group 2. In both groups, women with hypomagnesemia had a higher incidence of viral infections, vegetative-vascular dystonia, osteochondrosis and arterial hypertension, more pronounced sleep disorders, irritability, back pain, rapid fatigue, and higher MDQ scores. After completion of the course of therapy with magnesium citrate and pyridoxine combination, the MDQ scores in patients with DM decreased along with an increase in plasma magnesium concentration. Besides, women's satisfaction with their physical, psychological, social wellbeing and microsocial support increased, and self-perception improved. A decrease in the severity of DM and a significant improvement in QoL according to WHOQOL-26 were demonstrated in patients with CS and surgical menopause after therapy.Conclusion. The profile of patients with CS and surgical menopause, regardless of MHT, is often characterized by DM and decreased QoL. It seems reasonable to include blood magnesium level monitoring and DM correction in the comprehensive rehabilitation program for such patients.
Blood-brain barrier breach after acute cerebral hypoxia in infants
Authors: Aleksandrov A. G. , Blinov D. V. 
Published: September 2024

Background. Neuronal lesion, including hypoxic-ischemic damage to the central nervous system (CNS) in perinatal period, leads to the release of neuron-specific enolase (NSE) into peripheral bloodstream. Consequently, NSE can be considered as a biological marker of nervous system injury. Based on NSE level analysis, timely rehabilitation for newborns can be provided, thereby reducing the likelihood of complications associated with CNS injury.Objective: retrospective assessment of NSE level in peripheral blood over a 24-week period in infants of different gestational age with perinatal hypoxic-ischemic CNS damage.Material and methods. The study included 49 newborns who had suffered perinatal hypoxic-ischemic CNS lesion. Gestation period differed from 32 to 41 weeks. The control group consisted of 28 healthy full-term infants. NSE levels were measured using enzyme immunoassay. Patients of the main group were additionally divided into subgroups depending on Apgar scores at the 1st minute after birth, gestational age, as well as predominant CNS lesion – hemorrhagic with intraventricular hemorrhages or ischemic with periventricular leukomalacia.Results. Throughout the observation period, NSE concentrations were inversely correlated with Apgar scores: lower Apgar indicators were associated with higher NSE levels. In addition, the subgroup of 32–33-week gestational age had significantly higher NSE concentrations compared with 34–36-week, 37–41-week subgroups, and control group. NSE levels in infants with periventricular leukomalacia were consistently lower than those in newbornes with intraventricular hemorrhage starting from the 1st week. Notably, a delayed increase in serum NSE concentrations was observed at the 4th week.Conclusion. The obtained data indicate that blood-brain barrier permeability for NSE is preserved during perinatal hypoxicischemic CNS injury. Serum NSE concentration measurement can serve as a valuable tool in clinical practice for assessing the effectiveness of therapy at the stages of treatment and rehabilitation.
Формирование новой японской скульптуры
Authors: Кужель Юрий Леонидович 
Published: September 2024

<p>Предметом статьи является становление новой японской скульптуры конца XIX — первой трети XX в., а также переход мастерами ваяния от монументальности и пафоса конных статуй, скульптурных портретов героизированных исторических лиц к изображению реальной красоты тела человека, выразительности его позы. Подарив фигурам движение, скульпторы оживили их и внесли в свои работы богатую палитру живых эмоций и переживаний. Искусство японских скульпторов западного направления отразило эпоху с ее тенденцией к реалистическому обобщению. Автор стремится выявить, описать и понять, какими средствами достигается художественная выразительность скульптуры периода модернизации страны и формирования современного искусства, которому западная пластика придала свежий импульс. Методологически статья базируется на принципах комплексного подхода, использовании эмпирического материала, с помощью которого анализируются конкретные произведения. В процессе исследования применялись исторический, типологически-системный, аналитический методы.</p><p>Основным результатом данного исследования является возможность раскрытия специфических черт японской светской скульптуры. В качестве резюме в статье отмечается, что новое поколение мастеров объектами изображения выбрало не канонические персонажи из буддийского пантеона божеств — будд, бодхисаттв, светлых царей, небесных государей и др., а общественно значимые, знаковые фигуры из реальной японской истории и обычных людей из числа ученых, актеров и, что особенно ценно, женщин. В поле интересов скульпторов попали и представители животного мира. Кроме того, прослеживаются черты трансформации изображений героев в системе культурологических вызовов того времени, исторических фактов и эстетических законов, что вместе с расширением знаний о новой скульптуре Японии и через осознание ее роли и смыслов в контексте времени определяет новизну исследования.</p>
Que Comecem os Jogos: um Estudo sobre a Aprendizagem Baseada em Jogos na Educação Profissional e Tecnológica
Authors: Sylvestre Daniela Rebello Pereira , Silva Gleice Neves da , Carvalho Priscila Pereira de Jesus , Sondermann Danielli Veiga Carneiro 
Published: September 2024

A utilização de jogos como estratégia de ensino e aprendizagem é uma das possibilidades de ferramentas pedagógicas nos processos formativos. O artigo tem como objetivo conceituar a aprendizagem baseada em jogos e aprendizagem baseada em gamificação, buscando identificar o potencial dessas metodologias no processo de ensino e aprendizagem. Para isso, foi realizada a aplicação dessas metodologias ativas de ensino na turma de Práticas Educativas em Educação Profissional e Tecnológica do Mestrado em Educação Profissional e Tecnológica no segundo semestre do ano de 2023. A apresentação do conteúdo consistiu na aplicação prática das metodologias supracitadas por meio da recriação de um jogo brasileiro, intitulado Passa ou Repassa. A intervenção pedagógica demonstrou que a aprendizagem baseada em jogos ofereceu uma abordagem atrativa, eficiente e dinâmica para a promoção do ensino e aprendizagem, com potencialidade de transformar a experiência de aprendizado em Educação Profissional e Tecnológica mais significativa e eficaz para os educandos.

Palavras-chave: Metodologias ativas. Aprendizagem baseada em jogos. Gamificação. Educação profissional e tecnológica.
Jogo dos Mares: A geopolítica por trás das tensões no Mar do Sul da China
Authors: Kolling Gabriela Menezes , De Paula Maria Luiza Garcia , Feddersen Gustavo Henrique 
Published: September 2024

O Mar do Sul da China é caminho para muitos navios que o circulam levando trilhões de dólares em mercadorias, além de ser uma região rica em recursos como reservas de gás e óleo, o que o torna alvo de grandes reivindicações geopolíticas. Este trabalho visa contribuir para a discussão da importância do Mar do Sul da China no âmbito econômico, social e político, assim como analisar as estratégias das nações circunvizinhas ao MSC e as nações do hemisfério ocidental. China e Estados Unidos tomam o palco desta discussão, visto que ambos buscam hegemonia no continente Asiático e tem se estabelecido como nações líderes na esfera internacional. A presente pesquisa é baseada no uso de capacidades militares e políticas no sistema internacional, assim como conceitos teóricos que auxiliam na compreensão dos mesmos. Com isso, conclui-se que o uso e alcance dessas capacidades encontram-se em construção e tanto a nação norte-americana quanto asiática possuem grande influência e estratégias de poder suficientes para estabelecerem-se como superpotência na região.
From applicator-based (Paris system) implantations to rhinoseptoplasty: the concept of anatomic implantation for interventional radiotherapy in squamous cell carcinoma of the nasal vestibule. Short term results in a monoinstitutional series
Authors: Tropiano Paolo , Tagliaferri Luca , Tondo Andrea , Varrucciu Simona , Gallus Roberto , Mattiucci Gian Carlo , De Ridder Mischa , Rijken Johannes A. , Scheurleer W. F. Julius , D’Aviero Andrea , Fionda Bruno , Riu Francesco Giuseppe , Bussu Francesco 
Published: September 2024

Aim: Interventional radiotherapy (IRT) is being increasingly advocated as the standard treatment for the primary lesion in nasal vestibule squamous cell carcinoma (NV-SCC). The respect of the anatomical planes of the nose tip during implantation has been hypothesized to reduce the classical IRT toxicities on the cartilages, such as septal and even alar perforations. The present work describes a monoinstitutional series of NV-SCC treated with an IRT technique that follows the above principle (anatomical implantation), with a focus on IRT toxicities.
Methods: All consecutive patients with nasal vestibule (NV) carcinoma treated between March 2022 and October 2023 with IRT on the primary lesion at Azienda Ospedaliera Universitaria di Sassari and Mater Olbia Hospital were included.
Results: A total of 15 patients were treated with IRT following the principles of anatomical implantation. The only treatment-related toxicity observed has been the mechanical damage to the skin from the buttons used to stabilize the plastic tubes.
Conclusion: IRT with anatomical implantation allows a high nose preservation rate and very good cosmetic results, which appear to be decisive advantages in comparison with traditional surgery, while confirming comparable effectiveness from an oncological point of view. However, in the present series, we describe typical skin toxicity that may have a negative impact on cosmetic results. We propose a new strategy involving the use of a soft medium such as a sponge to protect the skin from damage.
Rancang Bangun Aplikasi GoHRD Online untuk Start-Up
Authors: Yudhanto Yudho , Sulandari Winita , Hidayat Taufiqurrakhman Nur , Purnomo Fendi Aji 
Published: September 2024

<p><strong>Abstrak </strong></p><p>Startup adalah perusahaan rintisan yang belum lama beroperasi. Dengan kata lain, startup artinya perusahaan yang baru masuk atau masih berada pada fase pengembangan atau penelitian untuk terus menemukan pasar meupun mengembangkan produknya. Problem klasik dalam Startup adalah perihal pengelolaan SDM (Sumber Daya Manusia), ini adalah penting sebagai elemen perusahaan dalam mencapai kesuksesan visi misinya. Sering terjadi tumpang tindih tugas dan kewenangan dikarenakan penghematan perusahaan. Selain itu juga proses manajemen SDM dari tugas dan penggajian belum menjadi prioritas karena mengejar pertumbuhan produk yang harus segera diselesaikan. HR (Human Resources) dalam StartUp sangat membutuhkan otomatisasi sehingga bisa berjalan dengan baik tanpa harus memberikan effort yang banyak dikarenakan semua dipusatkan untuk menyelesaikan produk. Aplikasi GoHRD dibuat sebagai solusi mudah dalam mengelola SDM Startup, dibangun dengan menggunakan PHP, MySQL dan Framework PHP. Metode pengembangan yang digunakan adalah Agile Scrum dengan tujuan penyelesaian yang cepat dan singkat. Model pengujian dilakukan dengan teknik Black box, hasilnya adalah dari 30 skenario pengujian mendapatkan 95% berjalan dengan baik sedangkan sisanya memerlukan kustomisasi agar lebih mudah untuk digunakan dan dikenali oleh user dengan baik.</p><p>====================================================</p><p><strong>Abstract</strong></p><p><em>Startup is a start-up company that has not been operating for a long time. In other words, a startup means a company that has just entered or is still in the development or research phase to continue to find markets and develop its products. The classic problem in startups is the management of HR (Human Resources), this is important as an element of the company in achieving the success of its vision and mission. Overlapping duties and authorities often occur due to company savings. Apart from that, the HR management process of assignments and payroll has not been a priority due to the pursuit of product growth which must be completed immediately. HR (Human Resources) in StartUp really needs automation so that it can run well without having to put in a lot of effort because everything is focused on completing the product. The GoHRD application was created as an easy solution for managing Startup HR, built using PHP, MySQL and the PHP Framework. The development method used is Agile Scrum with the goal of fast and short completion. The testing model was carried out using the Black box technique, the result is that 95% of the 30 test scenarios run well while the rest require customization to make it easier to use and well recognized by the user.</em></p>
Opinion-Tree-aware Prompt Tuning for Aspect Sentiment Quadruple Prediction
Authors: Zhang Zhibo , Yang Zhenyu , Li Zhijun 
Published: September 2024

Abstract

In recent years, Aspect Sentiment Quadruple Prediction (ASQP) has emerged as a prominent task in the field of aspect-based sentiment analysis. We observe complex dependencies among aspect sentiment elements, rendering traditional sequence-to-sequence (Seq2Seq) modeling for element extraction insufficiently rigorous. Additionally, despite the widespread application of Pre-trained Language Models (PLMs) in Aspect-Based Sentiment Analysis (ABSA), there is a significant gap when representing dependencies between sentiment elements, which involve complex structure-informed label classification, diverging from PLM's Masked Language Model (MLM) pre-training tasks. This gap limits the full potential of PLMs. To bridge this gap and better adapt to the structural information between sentiment elements, we propose a Opinion-Tree-aware Prompt Tuning (OTPT) method. This approach transforms traditional PLM Seq2Seq tasks into sequence-to-tree tasks, optimizing PLM potential. Specifically, we model sentiment elements as a tree structure, creating a dynamic virtual template and label words, integrating tree structure information as soft prompts, and conducting stepwise sentiment label classification. Extensive experiments show that our method achieves performance superior to baseline on two widely used datasets, demonstrating good robustness in handling cases of missing sentiment elements and complex multi-sentiment quadruples.