bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium Nanoparticle‐Immobilized Porous Polyurethane Material for Quick and Efficient Heterogeneous Catalysis of Suzuki‐Miyaura Cross‐Coupling Reaction at Room Temperature
Authors: Dey Sandeep Kumar , Dietrich Dennis , Wegner Susann , Gil‐Hernández Beatriz , Harmalkar Sarvesh Shyam , de Sousa Amadeu Nader , Janiak Christoph 
Published: February 2018

AbstractHere we report, room temperature heterogeneous catalysis of the Suzuki‐Miyaura cross‐coupling reaction by a Pd0 nanoparticle‐immobilized porous organic polymer (TPU‐Pd), providing excellent yields (up to 99%) using low catalyst loading. High nitrogen‐ and oxygen‐donor content of triazine‐based porous polyurethane (TPU) makes it an efficient porous polymer for Pd‐immobilization and subsequent heterogeneous catalysis of C–C cross‐coupling reactions. X‐ray photoelectron spectroscopy of TPU‐Pd showed characteristic binding energy peaks of Pd0. Atomic absorption spectroscopy revealed 10.4 wt% of Pd0 in TPU‐Pd, and transmission electron microscopy images showed well‐dispersed and facetted Pd0 nanoparticles of size 5–20 nm. Catalysis of Suzuki‐Miyaura reaction was observed to be completed in 3 h at 25 °C for a wide range of aryl halide substrates with phenylboronic acid, whereas increasing the reaction temperature to 80 °C largely allows decreasing the reaction time to 0.5‐1 h. The porosity and surface area of the catalyst was not affected after catalysis, and the catalyst has been reused for five consecutive runs.
Glutathione Mediated Size‐Tunable UCNPs‐Pt(IV)‐ZnFe2O4 Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy
Authors: Bi Huiting , Dai Yunlu , Yang Piaoping , Xu Jiating , Yang Dan , Gai Shili , He Fei , Liu Bin , Zhong Chongna , An Guanghui , Lin Jun 
Published: February 2018

AbstractHere a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)‐platinum(IV) (Pt(IV))‒ZnFe2O4, denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near‐infrared light can convert low energy photons to high energy ones, which act as the UV–vis source to simultaneously mediate the PDT effect and Fenton's reaction of ZnFe2O4 nanoparticles. Meanwhile, the Pt(IV) prodrugs can be reduced to high virulent Pt(II) by glutathione in the cancer cells, which can bond to DNA and inhibit the copy of DNA. The synergistic therapeutic effect is verified in vitro and in vivo results. The cleavage of Pt(IV) from UCNPs during the reduction process can shift the larger UCPZ nanoparticles (NPs) to the smaller ones, which promotes the enhanced permeability and retention (EPR) and deep tumor penetration. In addition, due to the inherent upconversion luminescence (UCL) and the doped Yb3+ and Fe3+ in UCPZ, this system can serve as a multimodality bioimaging contrast agent, covering UCL, X‐ray computed tomography, magnetic resonance imaging, and photoacoustic. A smart all‐in‐one imaging‐guided diagnosis and treatment system is realized, which should have a potential value in the treatment of tumor.
Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234
Authors: Liu Ling , Pan Jian , Wang Zilong , Yan Xiaohui , Yang Dong , Zhu Xiangcheng , Shen Ben , Duan Yanwen , Huang Yong 
Published: February 2018

Abstract
Tiancimycin (TNM) A, a recently discovered enediyne natural product from Streptomyces sp. CB03234, showed rapid and complete killing of cancer cells and could be used as a payload in antibody drug conjugates. The low yield of TNM A in the wild-type strain promoted us to use ribosome engineering and fermentation optimization for its yield improvement. The Streptomyces sp. CB03234-R-16 mutant strain with a L422P mutation in RpoB, the RNA polymerase β-subunit, was obtained from the rifamycin-resistant screening. After fermentation optimization, the titers of TNM A in Streptomyces sp. CB03234-R-16 reached to 22.5 ± 3.1 mg L−1 in shaking flasks, and 13 ± 1 mg L−1 in 15 L fermentors, which were at least 40-fold higher than that in the wild-type strain (~ 0.3 mg L−1). Quantitative real-time RT-PCR revealed markedly enhanced expression of key genes encoding TNM A biosynthetic enzymes and regulators in Streptomyces sp. CB03234-R-16. Our study should greatly facilitate the future efforts to develop TNM A into a clinical anticancer drug.
TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia
Authors: Del Guerra Alberto , Ahmad Salleh , Avram Mihai , Belcari Nicola , Berneking Arne , Biagi Laura , Bisogni Maria Giuseppina , Brandl Felix , Cabello Jorge , Camarlinghi Niccolò , Cerello Piergiorgio , Choi Chang-Hoon , Coli Silvia , Colpo Sabrina , Fleury Julien , Gagliardi Vito , Giraudo Giuseppe , Heekeren Karsten , Kawohl Wolfram , Kostou Theodora , Lefaucheur Jean-Luc , Lerche Christoph , Loudos George , Morrocchi Matteo , Muller Julien , Mustafa Mona , Neuner Irene , Papadimitroulas Panagiotis , Pennazio Francesco , Rajkumar Ravichandran , Brambilla Cláudia Régio , Rivoire Julien , Kops Elena Rota , Scheins Jürgen , Schimpf Rémy , Shah N. Jon , Sorg Christian , Sportelli Giancarlo , Tosetti Michela , Trinchero Riccardo , Wyss Christine , Ziegler Sibylle ,   TRIMAGE Consortium
Published: February 2018

AbstractSimultaneous PET/MR/EEG (Positron Emission Tomography – Magnetic Resonance – Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i.e., SiPM matrices), scintillators matrices (LYSO) and digital electronics. The combined PET/MR/EEG system is dedicated to brain imaging and has an inner diameter of 260 mm and an axial Field-of-View of 160 mm.It enables the acquisition and assessment of molecular metabolic information with high spatial and temporal resolution in a given brain simultaneously. The dopaminergic system and the glutamatergic system in schizophrenic patients are investigated via PET, the same physiological/pathophysiological conditions with regard to functional connectivity, via fMRI, and its electrophysiological signature via EEG. In addition to basic neuroscience questions addressing neurovascular-metabolic coupling, this new methodology lays the foundation for individual physiological and pathological fingerprints for a wide research field addressing healthy aging, gender effects, plasticity and different psychiatric and neurological diseases.The preliminary performances of two components of the imaging tool (PET and MR) are discussed. Initial results of the search of possible candidates for suitable schizophrenia biomarkers are also presented as obtained with PET/MR systems available to the collaboration.
A Culture of Neglect: A Study in Indonesian Court Judgements Regarding Victims of Domestic Violence
Authors: Abdurrachman Hamidah 
Published: February 2018

AbstractThe United Nations Commission on Crime Prevention and Treatment of Offenders treats domestic violence as a serious offence that affects groups of vulnerable populations, such as children, women and ethnic minorities. In Indonesia, the National Commission on Violence Against Women notes that in 2015 alone, there are recorded reports of 11,207 cases of domestic violence and 60% of those cases are violence against spouses, especially wives. However, many studies that have been done on domestic violence tend to take an indirect route towards reformation in the criminal justice system. This study tries to address some major obstacles to establish a more responsive criminal justice system in handling domestic violence cases. Through a qualitative analysis with statute and case approaches of Indonesian court judgements, this study analyses the system’s way of protecting/neglecting victims’ rights. There are four main obstacles to be discussed. First, many judges still regard domestic violence as a less serious offence, especially in regard to psychological intimidation. Second, punishment for the perpretators is quite moderate compared with the sufferings of the victims. Third, victims are only regarded in court as witnesses and denied their rights as victims. Fourth, there is a kind of social resistance from the community to report domestic violence as a crime. In sum, these obstacles illustrate a culture of neglect that is continuously reinforced by the community and the criminal justice system towards the victims’ physical and mental sufferings in the case of domestic violence.
Elder Abuse and Elder Victimization: A Sociological Analysis
Authors: Vardhan Ranjay 
Published: February 2018

AbstractIndia is home to one out of every 10 senior citizens of the world. According to the 2011 Census, 8.6% of people are aged above 60 years. A number of cases of elder abuse have been reported in the mass media as these people are easy victims of violence and criminal activities. Society comes to know about only those problems which are reported. Innumerable cases of disrespect and neglect are not given any consideration. The situation becomes even worse when perpetrators are very near relatives and in some cases blood relatives also. To overcome the problem a law, the “Maintenance and Welfare of Parents and Senior Citizens Act”, was passed in 2007. Based on primary data, the present paper will attempt to study the problems of the elderly with focus on gender, their abuse and victimization. The paper concludes that the majority of elders, especially those with little or no source of income, reside with their families and face abuse and victimization. Those who have a regular source of income face less abuse. To maintain confidentiality of family matters, elderly persons often do not report such crimes and undergo trauma.
The Infectious Disease Network (IDN): Development and Use for Evaluation of Potential Ebola Cases in Georgia
Authors: Turner Alezandria K. , Wages Robert K. , Nadeau Kelly , Edison Laura , Prince Peki F. , Doss Earnest R. , Drenzek Cherie , O’Neal Patrick 
Published: February 2018

AbstractIn response to the 2014 Ebola virus disease (EVD) outbreak in West Africa, the Georgia Department of Public Health developed the Infectious Disease Network (IDN) based on an EVD preparedness needs assessment of hospitals and Emergency Medical Services (EMS) providers. The network consists of 12 hospitals and 16 EMS providers with staff specially trained to provide a coordinated response and utilize appropriate personal protective equipment (PPE) for the transport or treatment of a suspected or confirmed serious communicable disease patient. To become a part of the network, each hospital and EMS provider had to demonstrate EVD capabilities in areas such as infection control, PPE, waste management, staffing and ongoing training, and patient transport and placement. To establish the network, the Georgia Department of Public Health provided training and equipment for EMS personnel, evaluated hospitals for EVD capabilities, structured communication flow, and defined responsibilities among partners. Since March 2015, the IDN has been used to transport, treat, and/or evaluate suspected or confirmed serious communicable disease cases while ensuring health care worker safety. Integrated infectious disease response systems among hospitals and EMS providers are critical to ensuring health care worker safety, and preventing or mitigating a serious communicable disease outbreak. (Disaster Med Public Health Preparedness. 2018;12:765-771)
Indigenous entrepreneurship on customary land in the Pacific: Measuring sustainability
Authors: Scheyvens Regina , Banks Glenn , Meo-Sewabu Litea , Decena Tracy 
Published: February 2018

AbstractCustomary land is commonly perceived as a barrier to economic development and indigenous entrepreneurship in Pacific Island countries. We turn this proposition on its head, arguing that customary land provides a solid foundation for indigenous entrepreneurs who wish to achieve social, cultural and environmental, as well as economic, goals for their businesses. Furthermore, we assert that appropriate tools are needed to measure the success of indigenous businesses on customary land, as conventional tools have a narrow focus on economics that fails to capture the more holistic, sustainable development goals that indigenous people hope to achieve through their businesses. The indicators we utilise relate to socio-cultural, economic and environmental sustainability. The tool’s usefulness was scrutinized through pre-testing on two indigenous businesses in Fiji; this revealed that culturally oriented tools are essential if the sustainability of indigenous business is to be measured in terms that are meaningful to Pacific communities.
A brief history of antidepressant drug development: from tricyclics to beyond ketamine
Authors: Pereira Vitor Silva , Hiroaki-Sato Vinícius Antonio 
Published: February 2018

ObjectiveAlthough monoaminergic-targeted drugs have prompted great advances in the development of treatments for depression, the need for new options persists, since these drugs still have a delayed clinical effect and most patients do not respond properly to them. Recently, the observation of the antidepressant effects of ketamine brought on a new wave of studies regarding the comprehension of the neurobiology of depression and the development of new and more effective antidepressant drugs.MethodsThus, in this paper, we present a historical review of the development of monoaminergic antidepressant drugs and the role of ketamine as the introductory agent of a new era in the research of the neurobiology of depression.ResultsFirstly, we review how the pharmacological treatment for major depression started, and we point out the main drugs discovered, the researchers involved, and how the studies developed have contributed to the understanding of the neurobiology of depression. Secondly, the major problems regarding the clinical efficacy and acceptance of these drugs are discussed, and the introduction of the glutamatergic system as a target for antidepressant drugs is presented. Finally, we review how ketamine revealed itself as an exciting option towards obtaining pharmacological agents to treat depression, through the understanding of biological markers.DiscussionKetamine contributed to confirm that different targets of the glutamatergic system and neurotrophic pathways are strictly related to the neurobiology of depression. There are several antidepressant drugs based on ketamine’s mechanism of action already in the pipeline, and glutamatergic-targeted antidepressants may be on the market in the near future.
Disparities in plain, tap and bottled water consumption among US adults: National Health and Nutrition Examination Survey (NHANES) 2007–2014
Authors: Rosinger Asher Y , Herrick Kirsten A , Wutich Amber Y , Yoder Jonathan S , Ogden Cynthia L 
Published: February 2018

AbstractObjectiveDifferences in bottled v. tap water intake may provide insights into health disparities, like risk of dental caries and inadequate hydration. We examined differences in plain, tap and bottled water consumption among US adults by sociodemographic characteristics.DesignCross-sectional analysis. We used 24 h dietary recall data to test differences in percentage consuming the water sources and mean intake between groups using Wald tests and multiple logistic and linear regression models.SettingNational Health and Nutrition Examination Survey (NHANES), 2007–2014.SubjectsA nationally representative sample of 20 676 adults aged ≥20 years.ResultsIn 2011–2014, 81·4 (se 0·6) % of adults drank plain water (sum of tap and bottled), 55·2 (se 1·4) % drank tap water and 33·4 (se 1·4) % drank bottled water on a given day. Adjusting for covariates, non-Hispanic (NH) Black and Hispanic adults had 0·44 (95 % CI 0·37, 0·53) and 0·55 (95 % CI 0·45, 0·66) times the odds of consuming tap water, and consumed B=−330 (se 45) ml and B=−180 (se 45) ml less tap water than NH White adults, respectively. NH Black, Hispanic and adults born outside the fifty US states or Washington, DC had 2·20 (95 % CI 1·79, 2·69), 2·37 (95 % CI 1·91, 2·94) and 1·46 (95 % CI 1·19, 1·79) times the odds of consuming bottled water than their NH White and US-born counterparts. In 2007–2010, water filtration was associated with higher odds of drinking plain and tap water.ConclusionsWhile most US adults consumed plain water, the source (i.e. tap or bottled) and amount differed by race/Hispanic origin, nativity status and education. Water filters may increase tap water consumption.
Validation of a picture book to be used in a pan-European dietary survey
Authors: Vilela Sofia , Lopes Carla , Guiomar Sofia , Severo Milton , Rangelova Lalka , Petrova Stefka , Horváth Zuszsanna , Cseh Júlia , Schweter Antje , Lindtner Oliver , Ambrus Árpád , Torres Duarte 
Published: February 2018

AbstractObjectiveTo validate a picture book for estimation of food portion sizes using two approaches: (i) ‘perception’ of food portions by comparison with a series of food photos; and (ii) ‘conceptualization and memory’, using the same photos to estimate the amount of served food one hour after self-served food portions.DesignEach partner developed a country-specific picture book based on the so-called EPIC-Soft picture book. Representative and common photo series were chosen achieving approximately 25 % of the original picture book (n23). Three portions from each photo series were randomly selected.SettingThe study was performed within the Pilot study in the view of a Pan-European dietary survey – Adolescents, adults and elderly (PILOT-PANEU) project.SubjectsA sample of adolescents and adults was recruited in five countries: Bulgaria (n103), Finland (n34), Germany (n69), Hungary (n62) and Portugal (n77).ResultsAmong the portions of the corresponding photo series and depending on the type of food, from 18 % (cheese) to 96 % (ratatouille) of participants chose the correct portions. In the perception study, agreement between the portions shown and reported was substantial (intraclass correlation coefficient (ICC)=0·805) and the mean difference was very low. In the memory study, agreement between the served and reported portions was lower than in the perception study (ICC=0·536). Agreement also seemed to decrease as the appearance of food on the plate differed from food in the picture.ConclusionsOverall, the picture series selected can be applied in future intake surveys to quantify foods similar to those depicted in the pictures.
How cover crop residue management and herbicide rate affect weed management and yield of tomato (Solanum lycopersicon L.) crop
Authors: Langeroodi Alireza Safahani , Radicetti Emanuele , Campiglia Enio 
Published: February 2018

AbstractIn the conventional cropping systems, increased costs and resource pollution are attributed to the intensive use of chemical inputs. The adoption of cover crops could be a part of a suitable strategy for improving the sustainability of the agro-ecosystems due to their ability to affect nutrient and weed management. A 2-yr field experiments were conducted in Gorgan, North of Iran, with the aim of assessing the effect of cover crop residue management and herbicide rates on weed management and the yield of tomato crop. The treatments consisted in: (a) three winter soil management: two cover crops [annual medic (Medicago scutellata L.) and barley (Hordeum vulgare L.)] and no covered soil; (b) two soil tillage (no-tillage, where cover crop residues were left in strips on the soil surface, and conventional tillage, where cover crop residues were green manured at 30 cm of soil depth); and (c) three pre-emergence herbicide rates (no-herbicide application, half rate recommended or full rate recommended ). Cover crops were sown in early September and mechanically suppressed in March about 2 weeks before tomato transplanting. At cover crop suppression, annual medic showed the highest aboveground biomass [569 g m−2 of dry matter (DM)], while barley showed the lowest weed content (32 g m−2 of DM). At tomato harvesting, weed density and aboveground biomass ranged from 6.9 to 61.5 plants m−2 and from 33.6 and 1157.0 g m−2 of DM, respectively. Cover crop residues placed on soil surface suppressed weeds more effectively than incorporated residues, especially in barley, mainly due to the physical barrier of residues which reduced the stimulation of weed germination and establishment. As expected, herbicide rate decreased both weed density and biomass, even if the adoption of annual medic and barley cover crops before the tomato cultivation could allow a possible reduction of herbicide rate while maintaining similar fruit yield. Tomato yield was higher in annual medic than barley and no cover regardless of tillage management (on average 62.3, 51.8 and 50.1 t ha−1 of fresh matter, respectively) probably due to an abundant availability of soil nitrogen throughout the tomato cultivation. This was confirmed by high and constant values of tomato N status grown in annual medic and evaluated using SPAD chlorophyll meter. Although further research of cover crop residue management is required to obtain a better understanding on herbicide rate reduction, these preliminary results could be extended to other vegetable crops which have similar requirements of tomato.
Maternal verbally aggressive behavior in early infancy is associated with blood pressure at age 5–6
Authors: Smarius L. J. C. A. , Strieder T. G. A. , Doreleijers T. A. H. , Vrijkotte T. G. M. , de Rooij S. R. 
Published: February 2018

AbstractEarly life stress has been shown to contribute to alterations in biobehavioral regulation. Whereas many different forms of childhood adversities have been studied in relation to cardiovascular outcomes, very little is known about potential associations between caregivers’ verbally aggressive behavior and heart rate and blood pressure in the child. This prospective study examined whether maternal verbally aggressive behavior in early infancy is associated with heart rate or blood pressure at age 5–6. In the Amsterdam Born Children and their Development study, a large prospective, population-based birth cohort, maternal verbally aggressive behavior was assessed by questionnaire in the 13th week after birth. The child’s blood pressure and heart rate were measured during rest at age 5–6 (n=2553 included). Maternal verbally aggressive behavior in infancy was associated with a higher systolic blood pressure (SBP) both in supine and sitting position after adjustment for sex, height and age (SBP supine B=1.01 mmHg; 95% CI [0.06; 1.95] and SPB sitting B=1.29 mmHg; 95% CI [0.12; 2.46]). Adjustment for potential confounding variables, such as other mother–infant dyad aspects, family hypertension and child’s BMI, only slightly attenuated the associations (SBP supine B=0.99 mmHg; 95% CI [0.06; 1.93] and SPB sitting B=1.11 mmHg; 95% CI [−0.06; 2.27]). Maternal verbally aggressive behavior was not associated with diastolic blood pressure or heart rate at age 5–6. Maternal verbally aggressive behavior might be an important early life stressor with negative impact on blood pressure later in life, which should be further investigated. Possible underlying mechanisms are discussed.