bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reading words hurts: the impact of pain sensitivity on people’s ratings of pain-related words
Authors: REUTER KEVIN , WERNING MARKUS , KUCHINKE LARS , COSENTINO ERICA 
Published: November 2016

abstractThis study explores the relation between pain sensitivity and the cognitive processing of words. 130 participants evaluated the pain-relatedness of a total of 600 two-syllabic nouns, and subsequently reported on their own pain sensitivity. The results demonstrate that pain-sensitive people associate words more strongly with pain than less sensitive people. In particular, concrete nouns like ‘syringe’, ‘wound’, ‘knife’, and ‘cactus’ are considered to be more pain-related for those who are more pain-sensitive. These findings dovetail with recent studies suggesting that certain bodily characteristics influence the way people form mental representations (Casasanto, 2009). We discuss three mechanisms which could potentially account for our findings: attention and memory bias, prototype analysis, and embodied cognition. We argue that, whereas none of these three accounts can be ruled out, the embodied cognition hypothesis provides a particularly promising view to accommodate our data.
The kyanite quartzite of Bosland (Suriname): evidence for a Precambrian metamorphosed alteration system
Authors: Bijnaar Ginny , van Bergen Manfred J. , Wong Theo E. 
Published: November 2016

AbstractThis article investigates the origin of a rare occurrence of kyanite quartzites in the Palaeoproterozoic greenstone belt of Suriname. The rocks form elongated hills in the Bosland area, Brokopondo district, where they are associated with meta-sedimentary, meta-volcanic and granitic lithologies. Their mineral content and unusual Si- and Al-rich chemical composition are inferred to be the result of advanced argillic alteration of felsic volcanic tuffs and a later overprint by regional metamorphism up to lower amphibolite facies during the Trans-Amazonian orogeny. Structurally, the Bosland area seems centred within a contractional strike-slip duplex of a major dextral fault system. The alteration was probably associated with a high-sulphidation environment and involved significant to almost complete removal of alkali and alkaline earth elements. Pseudosection modelling and textures suggest that the precipitation–temperature (P–T) history of the kyanite quartzites started with shallow (<2kbar) hydrothermal alteration of the acidic tuffaceous volcanics, possibly in the andalusite stability field (T>350°C), and ended in peak metamorphic conditions in the kyanite–staurolite stability field (P>4kbar andT=500–650°C). Alteration events that preceded the peak of Trans-Amazonian metamorphism may be more common in the rock record of Suriname's greenstone belt, which lends support to the hypothesis that gold mineralisations in the region can be pre-orogenic.
Validation of the Puumala virus rapid field test for bank voles in Germany
Authors: REIL D. , IMHOLT C. , ROSENFELD U. M. , DREWES S. , FISCHER S. , HEUSER E. , PETRAITYTE-BURNEIKIENE R. , ULRICH R. G. , JACOB J. 
Published: November 2016

SUMMARYPuumala virus (PUUV) causes many human infections in large parts of Europe and can lead to mild to moderate disease. The bank vole (Myodes glareolus) is the only reservoir of PUUV in Central Europe. A commercial PUUV rapid field test for rodents was validated for bank-vole blood samples collected in two PUUV-endemic regions in Germany (North Rhine-Westphalia and Baden-Württemberg). A comparison of the results of the rapid field test and standard ELISAs indicated a test efficacy of 93–95%, largely independent of the origin of the antigens used in the ELISA. In ELISAs, reactivity for the German PUUV strain was higher compared to the Swedish strain but not compared to the Finnish strain, which was used for the rapid field test. In conclusion, the use of the rapid field test can facilitate short-term estimation of PUUV seroprevalence in bank-vole populations in Germany and can aid in assessing human PUUV infection risk.
Markets and institutional swamps: tensions confronting entrepreneurs in developing countries
Authors: OLTHAAR MATTHIAS , DOLFSMA WILFRED , LUTZ CLEMENS , NOSELEIT FLORIAN 
Published: November 2016

AbstractUnrealized potential of entrepreneurial activities in developing countries has often been attributed to missing formal market-based institutions. In new institutional economics, the concept of ‘voids’ is suggested to describe the absence of market-based institutions. In reality, however, ‘institutional fabrics’ are always and necessarily complex and rich in institutions. No societal sphere is institutionally void. In this article, we contribute to existing literature on entrepreneurship and institutional economics by presenting a framework for studying the richness and complexities of institutional fabrics, as well as ways in which entrepreneurs respond to institutions. Distinguishing four types of institutions relevant for entrepreneurs, we analyze case study data from Ethiopia, and discuss how ‘tensions’ between potentially incompatible institutions result in behavioral frictions. Some entrepreneurs play the complex institutional environment and benefit from the tensions in it, whereas others may drown into the institutional ‘swamp’ they face. Policy makers should acknowledge that institutions not only result from formal policy making and that in many cases a diverse set of institutions is needed to facilitate market exchange and solve constraining tensions. The diversity that results from initiatives of institutional entrepreneurs may create a more effective institutional environment for development.
Informal norms trump formal constraints: the evolution of fiscal policy institutions in the United States
Authors: CALCAGNO PETER T. , LÓPEZ EDWARD J. 
Published: November 2016

AbstractTwo shifts of informal rules occurred in the decades around the turn of the 20th century that continue to shape U.S. fiscal policy outcomes. Spending norms in the electorate shifted to expand the scope of the government budget to promote economic security and macroeconomic stability. Simultaneously, norms for elected office shifted to careerism. Both norms were later codified into formal rules as legislation creating entitlement programs, macroeconomic responsibility, and organizational changes to the fiscal policy process. This institutional evolution increased demand for federal expenditures while creating budgetary commons, thus imparting strong motivations to spend through deficit finance in normal times. Despite the last four decades of legislative attempts to constrain spending relative to taxes, the informal norms have trumped the formal constraints. While the empirical literature on deficits has examined the constraining effects of informal rules, this paper offers a novel treatment of shifting norms as having expansionary effects on deficits.
The global legal system and the procedural construction of constituent power
Authors: THORNHILL CHRIS 
Published: November 2016

Abstract:This article proposes an alternative to more standard, neoclassical theories concerned with the proceduralisation of constituent power. It argues that more established theories of proceduralisation are insufficiently aligned to the sociological realities in which constituent power is located and expressed, and their residual fixation on the premises of classical constitutionalism impedes adequate understanding of constituent power in the global constitutional order of contemporary society. On this basis, the article offers a sociological examination of constituent power, which attempts to grasp constituent power in its objectively existing procedural form. In particular, it claims that constituent power now exists as an inner-legal function, activated through procedures within an increasingly differentiated legal system: whereas in classical theory constituent power was a primary political source of constitutional norms, it now appears only as a secondary expression of norms already contained within the global legal system. Rather than renouncing the idea of constituent power, however, the article uses its sociological focus to observe new procedural openings for the activation of constituent agency, adapted to the material/sociological fabric of contemporary society.
Implications of contested multilateralism for global constitutionalism
Authors: FOLLESDAL ANDREAS 
Published: November 2016

Abstract:The article considers implications of contested multilateralism for the processes and normative standards of global constitutionalism. The focus is primarily on aspects of CM regarded as a mode of constitutional change, considering what to make of such a form of ‘extra-constitutional’ procedure. Research challenges for political science, law and normative political theory are identified. Challenges by CM to the stability of international law are argued to be overdrawn. Of greater concern is that CM lends itself to piecemeal adjustments rather than reforms with an eye to the systemic effects. However, these worries must be tempered by the non-ideal nature of the present legal structure which should make us wary of imposing normative standards drawn from settings where institutions are fully just and generally complied with.
The Automaticity of Affordance of Dangerous Object
Authors: Zhao Liang 
Published: November 2016

AbstractObjects observation automatically elicits the activation of a reach-to-grasp response specifically directed to interact with the object, which is termed affordance. Murphy, van Velzen, and de Fockert (2012) found that only when an irrelevant object receives sufficient attention, it can potentiate an action. However, it remains unclear whether the dangerous object would afford an action when it receives insufficient attention. In this study, we manipulated the perceptual load in a letter identification task. Participants were required to identify a target letter with the right or left hand while ignoring a neutral or dangerous graspable object. The target letter was presented either on its own (low perceptual load), alongside five non-target letters (high load), or alongside eight non-target letters (super high load). Under the low perceptual load, for both neutral and dangerous object, responses were faster when the action afforded by the ignored object was congruent (vs. incongruent) with the current target response (t(27) = 4.44, p < .001; t(27) = 7.99, p < .001, respectively). However, during the high perceptual load, for dangerous object, responses were slower when the action afforded by the ignored object was congruent (vs. incongruent) with the current target response (t(27) = 4.97, p < .001). There was not any effect for both neutral object and dangerous object under super high perceptual load. These results suggest the affordance of dangerous object is also sensitive to the perceptual load. An irrelevant dangerous object can’t potentiate an action if it receives insufficient attention.
CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
Authors: Shaabani Namir , Duhan Vikas , Khairnar Vishal , Gassa Asmae , Ferrer-Tur Rita , Häussinger Dieter , Recher Mike , Zelinskyy Gennadiy , Liu Jia , Dittmer Ulf , Trilling Mirko , Scheu Stefanie , Hardt Cornelia , Lang Philipp A , Honke Nadine , Lang Karl S 
Published: November 2016

AbstractUpon infection with persistence-prone virus, type I interferon (IFN-I) mediates antiviral activity and also upregulates the expression of programmed death ligand 1 (PD-L1), and this upregulation can lead to CD8+ T-cell exhaustion. How these very diverse functions are regulated remains unknown. This study, using the lymphocytic choriomeningitis virus, showed that a subset of CD169+ macrophages in murine spleen and lymph nodes produced high amounts of IFN-I upon infection. Absence of CD169+ macrophages led to insufficient production of IFN-I, lower antiviral activity and persistence of virus. Lack of CD169+ macrophages also limited the IFN-I-dependent expression of PD-L1. Enhanced viral replication in the absence of PD-L1 led to persistence of virus and prevented CD8+ T-cell exhaustion. As a consequence, mice exhibited severe immunopathology and died quickly after infection. Therefore, CD169+ macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8+ T-cell exhaustion and immunopathology.
Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells
Authors: Cai Ming , He Jingquan , Xiong Jian , Tay Li Wei Rachel , Wang Ziqing , Rog Colin , Wang Jingshu , Xie Yizhao , Wang Guobin , Banno Yoshiko , Li Feng , Zhu Michael , Du Guangwei 
Published: November 2016

AbstractCancer cells utilize flexible metabolic programs to maintain viability and proliferation under stress conditions including nutrient deprivation. Here we report that phospholipase D1 (PLD1) participates in the regulation of metabolic plasticity in cancer cells. PLD1 activity is required for cancer cell survival during prolonged glucose deprivation. Blocking PLD1 sensitizes cancer cells to glycolysis inhibition by 2-deoxy-D-glucose (2-DG) and results in decreased autophagic flux, enlarged lysosomes, and increased lysosomal pH. Mechanistically, PLD1-regulated autophagy hydrolyzes bulk membrane phospholipids to supply fatty acids (FAs) for oxidation in mitochondria. In low glucose cultures, the blockade of fatty acid oxidation (FAO) by PLD1 inhibition suppresses adenosine triphosphate (ATP) production and increases reactive oxygen species (ROS), leading to cancer cell death. In summary, our findings reveal a novel role of PLD1 in sustaining cancer cell survival during metabolic stress, and suggest PLD1 as a potential target for anticancer metabolism therapy.
PAR2 regulates regeneration, transdifferentiation, and death
Authors: Piran Ron , Lee Seung-Hee , Kuss Pia , Hao Ergeng , Newlin Robbin , Millán José Luis , Levine Fred 
Published: November 2016

AbstractUnderstanding the mechanisms by which cells sense and respond to injury is central to developing therapies to enhance tissue regeneration. Previously, we showed that pancreatic injury consisting of acinar cell damage+β-cell ablation led to islet cell transdifferentiation. Here, we report that the molecular mechanism for this requires activating protease-activated receptor-2 (PAR2), a G-protein-coupled receptor. PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence ofβ-cells. Its expression was modulated in an islet cell type-specific manner in murine and human type 1 diabetes (T1D). In addition to transdifferentiation, PAR2 regulatedβ-cell apoptosis in pancreatitis. PAR2’s role in regeneration is broad, as mice lacking PAR2 had marked phenotypes in response to injury in the liver and in digit regeneration following amputation. These studies provide a pharmacologically relevant target to induce tissue regeneration in a number of diseases, including T1D.
The flux qubit revisited to enhance coherence and reproducibility
Authors: Yan Fei , Gustavsson Simon , Kamal Archana , Birenbaum Jeffrey , Sears Adam P , Hover David , Gudmundsen Ted J. , Rosenberg Danna , Samach Gabriel , Weber S , Yoder Jonilyn L. , Orlando Terry P. , Clarke John , Kerman Andrew J. , Oliver William D. 
Published: November 2016

AbstractThe scalable application of quantum information science will stand on reproducible and controllable high-coherence quantum bits (qubits). Here, we revisit the design and fabrication of the superconducting flux qubit, achieving a planar device with broad-frequency tunability, strong anharmonicity, high reproducibility and relaxation times in excess of 40 μs at its flux-insensitive point. Qubit relaxation times T1 across 22 qubits are consistently matched with a single model involving resonator loss, ohmic charge noise and 1/f-flux noise, a noise source previously considered primarily in the context of dephasing. We furthermore demonstrate that qubit dephasing at the flux-insensitive point is dominated by residual thermal-photons in the readout resonator. The resulting photon shot noise is mitigated using a dynamical decoupling protocol, resulting in T2≈85 μs, approximately the 2T1 limit. In addition to realizing an improved flux qubit, our results uniquely identify photon shot noise as limiting T2 in contemporary qubits based on transverse qubit–resonator interaction.
Following lithiation fronts in paramagnetic electrodes with in situ magnetic resonance spectroscopic imaging
Authors: Tang Mingxue , Sarou-Kanian Vincent , Melin Philippe , Leriche Jean-Bernard , Ménétrier Michel , Tarascon Jean-Marie , Deschamps Michaël , Salager Elodie 
Published: November 2016

AbstractLi-ion batteries are invaluable for portable electronics and vehicle electrification. A better knowledge of compositional variations within the electrodes during battery operation is, however, still needed to keep improving their performance. Although essential in the medical field, magnetic resonance imaging of solid paramagnetic battery materials is challenging due to the short lifetime of their signals. Here we develop the scanning image-selected in situ spectroscopy approach, using the strongest commercially available magnetic field gradient. We demonstrate the 7Li magnetic resonance spectroscopic image of a 5 mm-diameter operating battery with a resolution of 100 μm. The time-resolved image-spectra enable the visualization in situ of the displacement of lithiation fronts inside thick paramagnetic electrodes during battery operation. Such observations are critical to identify the key limiting parameters for high-capacity and fast-cycling batteries. This non-invasive technique also offers opportunities to study devices containing paramagnetic materials while operating.
Recent developments in the diagnosis and management of tuberculosis
Authors: Sulis Giorgia , Centis Rosella , Sotgiu Giovanni , D’Ambrosio Lia , Pontali Emanuele , Spanevello Antonio , Matteelli Alberto , Zumla Alimuddin , Migliori Giovanni Battista 
Published: November 2016

AbstractTuberculosis (TB) is a major public health issue worldwide, with ~9.6 million new incident cases and 1.5 million deaths in 2014. The End-TB Strategy launched by the World Health Organization in the context of the post-2015 agenda aims to markedly abate the scourge of TB towards global elimination, by improving current diagnostic and therapeutic practices, promoting preventative interventions, stimulating government commitment and increased financing, and intensifying research and innovation. The emergence and spread of multidrug-resistant strains is currently among the greatest concerns, which may hinder the achievement of future goals. It is crucial that primary healthcare providers are sufficiently familiar with the basic principles of TB diagnosis and care, to ensure early case detection and prompt referral to specialised centres for treatment initiation and follow-up. Given their special relationship with patients, they are in the best position to promote educational interventions and identify at-risk individuals as well as to improve adherence to treatment.
Adaptive capacities from survival to stress responses of two isogenic lines of rainbow trout fed a plant-based diet
Authors: Sadoul B. , Foucard A. , Valotaire C. , Labbé L. , Goardon L. , LeCalvez J. M. , Médale F. , Quillet E. , Dupont-Nivet M. , Geurden I. , Prunet P. , Colson V. 
Published: November 2016

AbstractThe composition of feed for farmed salmonids has strongly evolved during the last decades due to the substitution of fishery-derived fish oil and fishmeal by ingredients of plant origin. Little information is available regarding the effects of this transition on adaptive capacities in fish. Two rainbow trout isogenic lines, known for their divergent ability to grow on a plant-based diet (PBD), were fed for seven months from first feeding either a fully PBD or a control marine-resources diet and were compared for their growing and survival capacities over time and their behavioral and stress responses at similar sizes but different ages. Although fish displayed similar appetitive behaviour, the two lines were highly affected by the PBD translated in decreased growth and apathetic behaviour, but also stronger stress responses displayed by stronger cortisol increases and more stress-related behaviour when isolated. The two lines were found to be similarly sensitive to a PBD for the assessed stress-related parameters, but one line displayed a lower survival during the early rearing period. Overall, these results suggest that a PBD supplied to fish from the alevin stage has strong effects on physiological and behavioural parameters, with possible impairment of fish welfare, but also genome-dependent survival.
HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells
Authors: Jia Rong , Zhang Si , Liu Miaomiao , Zhang Yan , Liu Yu , Fan Mingwen , Guo Jihua 
Published: November 2016

AbstractOral squamous cell carcinoma (OSCC) is the leading cause of death related to oral diseases. The mechanisms of OSCC development remain largely unknown. Heterogeneous nuclear ribonucleoprotein L (HnRNP L) is a multi-functional splicing factor. It has been reported to be an important regulator of apoptosis. However, the functions of hnRNP L in cancer need to be further explored. In the present study, we found that OSCC tissues expressed significantly higher levels of hnRNP L than normal tissues. Depletion of hnRNP L retarded cell growth, cell migration, and tumorigenesis of OSCC cells. HnRNP L regulates both the expression of oncogenic splicing factor SRSF3 and the alternative splicing of SRSF3 exon 4. Expression of hnRNP L is correlated with SRSF3 expression in OSCC tissues. These findings suggest that hnRNP L is important for the pathogenesis of OSCC and may be a novel potential therapeutic target of OSCC.
Bioinspired seeding of biomaterials using three dimensional microtissues induces chondrogenic stem cell differentiation and cartilage formation under growth factor free conditions
Authors: Leijten J. , Teixeira L. S. Moreira , Bolander J. , Ji W. , Vanspauwen B. , Lammertyn J. , Schrooten J. , Luyten F. P. 
Published: November 2016

AbstractCell laden biomaterials are archetypically seeded with individual cells and steered into the desired behavior using exogenous stimuli to control growth and differentiation. In contrast, direct cell-cell contact is instructive and even essential for natural tissue formation. Namely, microaggregation and condensation of mesenchymal progenitor cells triggers chondrogenesis and thereby drives limb formation. Yet a biomimetic strategy translating this approach into a cell laden biomaterial-based therapy has remained largely unexplored. Here, we integrate the microenvironment of cellular condensation into biomaterials by encapsulating microaggregates of a hundred human periosteum-derived stem cells. This resulted in decreased stemness-related markers, up regulation of chondrogenic genes and improved in vivo cartilage tissue formation, as compared to single cell seeded biomaterials. Importantly, even in the absence of exogenous growth factors, the microaggregate laden hydrogels outperformed conventional single cell laden hydrogels containing supraphysiological levels of the chondrogenic growth factor TGFB. Overall, the bioinspired seeding strategy described herein represents an efficient and growth factor-free approach to efficiently steer cell fate and drive tissue formation for biomaterial-based tissue engineering strategies.