bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing Patent Terms and Citations to Determine the Value of Gene Therapies
Authors: Van Dongen Peter , El Hejazi Zainab Noor , Claassen Eric 
Published: August 2017

Gene therapies hold great promise for treatment of diseases but so far their market authorisation has been limited. This paper describes the development of patented gene therapies in the sector of life sciences and health. It was found that the annual number of patented gene therapies increased significantly till the year 2005. A cluster analysis of gene therapies patented in 1995 shows that: a) more than eighty percent has been renewed for more than fifteen years (fifty three per cent till the maximum patent term) and b) fifty per cent of the patents have been licensed. There is a statistically significant correlation between the numbers of citations in future patent applications by third parties and the number of years of patent renewals. A case study of the patent EP 0833934 of biotechnology start- up Crucell demonstrates that the number of citations by third companies to this patent even predicts the companies’ market capitalization. This research yielded evidence that the number of patent citations can be used as indicator to determine the value of gene therapies. Such information is of relevance for both the patentee and investors.
Genetic Diversity Assessment and its Importance on Crop improvement in Ethiopia: Potentials and challenges
Authors: Hora Obssi Dessalegn , Amebaw Abebaw Misganaw 
Published: August 2017

Genetic diversity assessments of plant play a great role in a predictable area to improve agricultural production and productivity, to solve food uncertainty in developing world. Many breeders has tried to realized that crop with diverge genetic diversity can be assessed , evaluated ,captured and stored in the form of superior plant genetic resources such as gene bank, DNA library to preserve genetic material for long period. However, the conserved genetically diversified plant must be utilized to improve crop production in order to solve future food and nutritional challenges. This paper reviews eight important areas; (i) Gaps in Developing Taxonomy of Ethiopian crops (ii) Monitoring diversity for crop improvement, (iii) Alterations in landscape features, (iv) Significance of Germplasm Conservation of crops, (v) Gap in morphological characterization, (vi) Global perspective of agro biodiversity and molecular evolution, (vii) Emergence of tissue culture technology in Ethiopia (viii) Germplasm improvement. It provides basic enlightenment for plant breeders for better understanding and rapid diversity assessment of crop, for better understanding and utilization of germplasm from gene banks to their applied breeding programs. With the advent of new biotechnological techniques, this process of conventional breeding is now being accelerated and carried out with more precision and speedy manner than the classical breeding techniques by using molecular markers to avoid taxonomic confusion. For sustainable food production, conventional plant breeding research should have integration with molecular marker assisted evaluation of crops genetic diversity and/or cultivar improvement will be achieved. As a result, availability and access to diverse genetic sources will ensure that the global food production network becomes more sustainable. The merit and demerit of the basic morphological characterizations are briefly discussed and their source links were provided to get easy access; thus, it improves the understanding of modern molecular tools and its practical applicability to the breeders.
Accueillir les élèves migrants : dispositifs et interactions à l’école publique en France
Authors: Rigoni Isabelle 
Published: August 2017

La France est un vieux pays d'immigration accueillant des familles depuis la fin du 19e siècle. Depuis, les flux migratoires n’ont cessé de se diversifier et de se complexifier. Le défi est de taille pour les travailleurs sociaux, mais également pour l’institution scolaire, qui doit intégrer chaque année plusieurs dizaines de milliers d’élèves migrants. Si l’école française est obligatoire pour tous les enfants depuis 1882, les aménagements pour les élèves allophones arrivants sont une disposition relativement récente. Comment penser l’accueil scolaire de ces enfants et de ces jeunes, inscrits parfois dans des contextes paupérisés et stigmatisés et dans lesquels les enjeux sociaux, politiques et politiques sont déjà nombreux? Comment également penser les tensions politiques qui entourent les questions migratoires, et quelles en sont les conséquences pour les élèves et les personnes qui les accompagnent? Cet article propose une analyse des rapports qui se nouent entre différents acteurs de l’éducation en interaction (enseignants, intervenants sociaux et éducatifs) et la structuration des expériences éducatives d’enfants et jeunes migrants. Il s’agit d’analyser la capacité des acteurs professionnels à apporter un appui ajusté et pertinent aux difficultés et aux exigences auxquelles les enfants et jeunes sont soumis dans des cadres éducatifs normatifs et contraignants. Nous nous appuyons sur les résultats de plusieurs programmes de recherche visant, au moyen d’entretiens semi-directifs mais aussi d’observations et de méthodes collaboratives et participatives, à mieux connaître les conditions effectives d’accueil et de scolarisation offertes par les institutions scolaire et d’intervention sociale, afin d’appréhender les fonctionnements institutionnels au regard des attentes des familles et de leurs enfants, d’analyser les expériences migratoire et scolaire des enfants et jeunes et enfin de saisir les dimensions pluri-professionnelles de l’accompagnement éducatif pour ces populations.
Tracing hepatitis B virus (HBV) genotype B5 (formerly B6) evolutionary history in the circumpolar Arctic through phylogeographic modelling
Authors: Bouckaert Remco , Simons Brenna C. , Krarup Henrik , Friesen T. Max , Osiowy Carla 
Published: August 2017

BackgroundIndigenous populations of the circumpolar Arctic are considered to be endemically infected (>2% prevalence) with hepatitis B virus (HBV), with subgenotype B5 (formerly B6) unique to these populations. The distinctive properties of HBV/B5, including high nucleotide diversity yet no significant liver disease, suggest virus adaptation through long-term host-pathogen association.MethodsTo investigate the origin and evolutionary spread of HBV/B5 into the circumpolar Arctic, fifty-seven partial and full genome sequences from Alaska, Canada and Greenland, having known location and sampling dates spanning 40 years, were phylogeographically investigated by Bayesian analysis (BEAST 2) using a reversible-jump-based substitution model and a clock rate estimated at 4.1 × 10−5substitutions/site/year.ResultsFollowing an initial divergence from an Asian viral ancestor approximately 1954 years before present (YBP; 95% highest probability density interval [1188, 2901]), HBV/B5 coalescence occurred almost 1000 years later. Surprisingly, the HBV/B5 ancestor appears to locate first to Greenland in a rapid coastal route progression based on the landscape aware geographic model, with subsequent B5 evolution and spread westward. Bayesian skyline plot analysis demonstrated an HBV/B5 population expansion occurring approximately 400 YBP, coinciding with the disruption of the Neo-Eskimo Thule culture into more heterogeneous and regionally distinct Inuit populations throughout the North American Arctic.DiscussionHBV/B5 origin and spread appears to occur coincident with the movement of Neo-Eskimo (Inuit) populations within the past 1000 years, further supporting the hypothesis of HBV/host co-expansion, and illustrating the concept of host-pathogen adaptation and balance.
DEPRECIAÇÃO NO SETOR PÚBLICO: UMA ANÁLISE DA EVOLUÇÃO DA EVIDENCIAÇÃO CONTÁBIL NOS ÓRGÃOS DA ADMINISTRAÇÃO PÚBLICA DO ESTADO DO AMAZONAS
Authors: Da Silva Luciene Lima , Eleuterio Raul Agusto Da Silva , Viana Clilson Castro , Lima Mariomar De Sales 
Published: August 2017

<p>Sob a ótica das mudanças trazidas pela convergência às normas internacionais de contabilidade, em especial, no tocante a implementação dos procedimentos relacionados à depreciação no setor público, a presente pesquisa objetivou examinar a evolução na evidenciação da contabilização da depreciação dos bens móveis e imóveis pertencentes aos órgãos que compõem a Administração Pública do Estado do Amazonas, nos exercícios de 2012 a 2014. Salienta-se que, apesar da previsão contida nas Leis n° 4.320 de 1964 e Lei n° 101 de 2000 (Lei de Responsabilidade Fiscal - LRF), a normatização de tais procedimentos só ocorreu com a divulgação da Resolução CFC nº 1.136/2008 (NBC T SP 16.9). Para o alcance do objetivo citado o presente estudo se deu através de levantamento, organização e análise de dados relativos aos valores da depreciação e patrimônio total evidenciados nos exercícios mencionados, sendo estes extraídos de Portais de Transparência e/ou obtidos através de consultas realizadas junto ao Departamento de Contabilidade da Secretaria de Estado da Fazenda do Estado do Amazonas – SEFAZ/AM. Ademais, justifica-se relevância da pesquisa por se tratarem de procedimentos recentemente implementados, fazendo, consequentemente o tema ser pouco explorado no Estado, e ainda, originar a discussão quanto ao nível de atendimento ao disposto nas Normas Brasileiras de Contabilidade Aplicadas ao Setor Público, bem como, visa promover uma contribuição à sociedade para gerar uma maior observância no tocante à clareza das informações públicas sobre o valor de bens móveis e imóveis e sua desvalorização reconhecida pela contabilidade na forma de depreciação. Como resultado, constatou-se que nos três exercícios analisados o número de unidades gestoras ativas foi de, em média 138 órgãos, sendo que a evidenciação da depreciação foi realizada por aproximadamente 18,39% destas unidades. Em relação ao valor do ativo imobilizado demonstrado, observou-se que os bens incorporados durante os três exercícios representaram um acréscimo de R$ 2.769.389.456,60 ao patrimônio do Estado. Em contrapartida, a depreciação contabilizada nos mesmos exercícios foi de R$ 10.308.622,98, o equivale a menos de 1% do total de bens incorporados, ainda nesta seara, pode-se observar que a quantidade de entidades que evidenciaram valores relacionados a depreciação representa menos de 50% do número de unidades ativas nos três exercícios. Neste contexto, as conclusões rementem a um nível insatisfatório de atendimento ao disposto na NBC T SP 16.9, bem como a Lei nº 4.320/64 e LRF e demonstrando a afetação ocorrida na transparência do correto uso dos bens públicos, bem como as informações geradas pela contabilidade e que são necessárias para a correta tomada de decisão.</p><p> </p>
Orogenic arc-related Ni-Cu-(PGE) mineralization of the Ransko massif, Czech Republic, and implications for the metallogeny of the European Variscan belt
Authors: Ackerman Lukáš , Wertich Vojtěch , Pašava Jan , Kubeš Martin , Rambousek Petr , Míková Jitka , Sláma Jiří , Santolík Václav , Pack Andreas , Creaser Robert A. , Malý Karel , Magna Tomáš 
Published: February 2025

Abstract
The Ransko (ultra)mafic massif, Bohemian Massif, Czech Republic, hosts several Ni–Cu–(PGE) deposits and peculiar Zn–Cu–Ba ores. Geochronology integrated with petrography, bulk-rock, and mineral compositions together with Sr–Nd–Pb–Hf–Os–O isotopic systematics of barren and variably mineralized (ultra)mafic lithologies as well as massive ores reveal a complex evolution of the Ransko massif and its mineralizations. The Sm–Nd and U–Pb ages obtained for gabbros and cross-cutting granite porphyry, respectively, overlap with Re–Os ages of Ni–Cu–(PGE) and Zn–Cu ores and limit the formation age of (ultra)mafic rocks and metal accumulations to ~ 370–345 Ma. Compositional variations indicate derivation of parental melts of the Ransko massif from metasomatized, Variscan sub-arc mantle and underscore the importance of assimilation–fractional crystallization and crystal accumulation processes. The Ni–Cu ores were emplaced through the gravity-driven percolation of dense sulfide liquids along previously weakened structures associated with the downward crystal fractionation. The orogenic and arc-related nature of the Ransko Ni–Cu–(PGE) mineralization shares some remarkable similarities with some other Ni–Cu deposits in the European Variscan Belt highlighting the significance of these deposits emplaced in arc-related crustal domains. Yet, the variable nature of these mineralizations indicates complex processes that happen during the emplacement and evolution of the parental magmas driving their favourable metal contents.
Barriers and facilitators to accessing sexual and reproductive health services for people with severe mental illness: a systematic review
Authors: Brown Matilda , Tassie Emma , Carlisle Sophie , Covshoff Elana , Ronaldson Amy , Williams Julie , Smith Shubulade , Trevillion Kylee , Hughes Elizabeth , Heslin Margaret 
Published: February 2025

Abstract

Purpose
Despite increased prevalence of sexual and reproductive health problems among people with severe mental illness (SMI), uptake of sexual and reproductive healthcare in this group is poor. The reasons for this are unclear. Therefore, this review aimed to identify the barriers and facilitators to accessing sexual and reproductive health services from a service user perspective.

Methods
Three electronic databases were searched using key words for “sexual health” and “SMI”. Data were screened and extracted by two independent reviewers. The Joanna Briggs Institute Critical Appraisal Tools were used to assess quality of included studies.

Results
Five studies were included and underwent a narrative synthesis. They were on access to HIV care (n2), access to family planning methods (n2) and access to general sexual healthcare (n1). Barriers relating to HIV care included cost; barriers relating to family planning included lack of awareness and not considering the issue; barriers to general sexual healthcare included psychotic symptoms, mental health prioritisation, stigma, lack of sexual health focus in mental health programs, difficulty initiating conversations, knowledge, culture/religion/ethnicity, and finances.

Conclusions
Studies which examined access to HIV and family planning services did so in a way that limited participant responses. While only one study examined barriers and facilitators to accessing generic sexual health services, it did so robustly, although it focussed solely on young women and provided limited data on facilitators. Future work should focus on examining barriers, and facilitators, to accessing sexual healthcare in all people with SMI to better identify and address these challenges.

PROSPERO ID CRD42023414740.
Fat reduction and lipid profile optimization in Spanish spreadable meat product using an oil-in-water emulsion
Authors: Martínez Elena , Rabadán Adrián , Álvarez-Ortí Manuel , Mitre Jacqueline , Pardo José Emilio 
Published: February 2025

Abstract
The present study investigates the effects of an oil-in-water emulsion formulated with pistachio, almond, and walnut oils as replacements for pork fat in a typical Spanish spreadable product called sobrasada. The study evaluates the physical properties, nutritional composition, fatty acid profile, TBARS (thiobarbituric acid reactive substances), vitamin E content, and sensory characteristics of the product. Seven formulations were studied. On day 0, sensory analysis and physical properties were evaluated. On day 7, analyses included vitamin E content, fat profile, nutritional composition, and TBARS to measure lipid oxidation. The 50% and 100% fat replacement levels showed noticeable differences in color, particularly in lightness. Regarding texture parameters, the reformulated samples were more spreadable compared to the control sample, exhibiting significantly lower firmness, consistency, and cohesiveness, which indicated reduced resistance to spreading. In terms of nutritional composition, the primary achievement was a reduction in total fat content, ranging from 11% in the almond 50% formulation to 25.8% in the walnut 100% formulation, compared to the control. The use of nut oils significantly influenced the fatty acid profile, reducing saturated fatty acids (SFA) by up to 64.16% (in the almond 100% formulation) while increasing monounsaturated fatty acids (MUFA) by up to 51.24% (in the almond 100% formulation) and polyunsaturated fatty acids (PUFA) by up to 225.81% (in the walnut 100% formulation). Additionally, atherogenic and thrombogenic indexes decreased as the nut oil content increased in the formulations, and vitamin E levels were higher in the reformulated products. From a sensory perspective, consumers generally rated the new formulations as superior to the traditional sample in terms of flavor, appearance, and texture. In conclusion, replacing pork fat with nut oils resulted in a product with improved nutritional and sensory qualities compared to the traditional sobrasada.
A collection of cancellative, singly aligned, non-group embeddable monoids
Authors: Edwardes Milo , Heath Daniel 
Published: February 2025

Abstract
By classical results of Malcev, cancellative monoids need not be group-embeddable. We describe, give presentations for and study an infinite family

$${\mathcal {M}}_n$$

M
n

of cancellative monoids which are not group-embeddable, originating from Malcev’s work. We show that

$${\mathcal {M}}_n$$

M
n

is singly aligned for

$$n \ge 2$$

n
≥
2

, owing to applications in the study of

$$\textrm{C}^*$$

C
∗

-algebras by Brix, Bruce and Dor-On. We finish by showing that

$${\mathcal {M}}_1$$

M
1

is not singly aligned, but 2-aligned.
Total psoriasis regression in a patient with chronic myeloid leukemia treated using nilotinib
Authors: Horňák Tomáš , Žáčková Daniela , Mayer Jiří 
Published: February 2025

Abstract
Chronic myeloid leukemia (CML) treatment has been revolutionized over last 20 years because of tyrosine kinase inhibitors (TKIs) and patients with CML now have life expectancy of general population. Chronic TKI treatment may cause adverse effects (AEs) that vary in frequency and severity. Nilotinib shows common AEs with metabolic changes and skin AEs. Here, we present a case report of patient who experienced full psoriasis regression while treated with nilotinib. Dose reductions and an attempt to stop nilotinib treatment resulted in prompt psoriasis reappearance. This is the first documented case of positive effect of nilotinib on psoriasis.
Evaluation of Bruton’s Tyrosine Kinase (BTK) inhibition with alternative doses of ibrutinib in subjects with Chronic Lymphocytic Leukemia (CLL)
Authors: Ouerdani Aziz , Valenzuela Belén , Treijtel Nicoline , Haddish-Berhane Nahor , Desphande Sanjay , Srinivasan Srimathi , Smith Emma , Perez Ruixo Juan José 
Published: February 2025

Abstract

Purpose
To evaluate alternative ibrutinib dosing regimens that maintain Bruton’s tyrosine kinase (BTK) receptor occupancy over the entire dosing interval for CLL patients using a model-based approach.

Methods
Ibrutinib inhibits B-cell proliferation via irreversible binding of BTK. As IC50 is not an appropriate parameter to describe the potency of the inhibition in the presence of a covalent binding inhibitor. A BTK covalent binding model was developed using k

inact

/K

I
as key parameter to account for covalent binding. The ibrutinib-BTK covalent binding model was used to describe the effect of daily doses of 140, 280, 420 and 560 mg on the proportion of subjects with more than 90% BTK inhibition at steady state trough concentrations. Predictive performance of the model was assessed using the available ibrutinib BTK inhibition data following QD dosing. Model-based predictions were used to identify the minimum ibrutinib QD dose that provides more than 90% inhibition in more than 90% of the subjects.

Results
The covalent binding model was able to describe the data and predicted that ibrutinib QD dose reduced from 420 mg to 280 mg or 140 mg may inhibit de novo synthetized BTK efficiently in a CLL population.

Conclusion
Using a model-based approach showed that reducing the ibrutinib dosing regimen to 280 mg QD or even 140 mg in case of adverse events could maintain BTK inhibition over the entire dosing interval.
Impact of follow-up liver biopsy on long-term outcomes post-Kasai procedure in patients with biliary atresia
Authors: Takase Koki , Ueno Takehisa , Matsumoto Sayaka , Uga Naoko , Deguchi Koichi , Nomura Motonari , Watanabe Miho , Kamiyama Masafumi , Tazuke Yuko , Kimura Takeshi , Okuyama Hiroomi 
Published: February 2025

Abstract

Purpose
Patients with biliary atresia (BA) suffer from progressive liver damage, even after successful Kasai portoenterostomy (KPE). The purpose of this study is to analyze the relevance of follow-up percutaneous liver biopsy (LBx) and long-term prognosis of patients with BA.

Methods
This study included patients with BA who were born between 1983 and 2005 and survived with their native liver until 10 years of age. Patient characteristics, laboratory data and Child–Pugh score at the time of LBx, and native-liver survival (NLS) and complication-free survival (CFS) in patients with mild (F0-F2) or severe fibrosis (F3, F4) on follow-up LBx were retrospectively analyzed.

Results
Forty-three patients were gathered in this study and the most recent LBx was performed at age 21.1 ± 2.9 years. Thirty-three patients had mild fibrosis and ten patients had severe fibrosis on follow-up LBx. Long-term NLS and CFS were significantly worse in patients with severe fibrosis. Among those patients, 18 patients had follow-up LBx between the ages of 6 and 12 years, and CFS were significantly worse in patients with severe fibrosis.

Conclusions
We found that patients with BA with severe liver fibrosis on follow-up LBx had worse long-term survival and a higher rate of progression of complications of BA.
The presence of the reverse distance effect depends on the familiarity of the sequences being processed
Authors: Devlin Declan , Moeller Korbinian , Xenidou-Dervou Iro , Reynvoet Bert , Sella Francesco 
Published: February 2025

Abstract
Number order processing is thought to be characterised by a reverse distance effect whereby consecutive sequences (e.g., 1–2–3) are processed faster than non-consecutive sequences (e.g., 1–3–5). However, there is accumulating evidence that the reverse distance effect is not consistently observed. In this context, the present study investigated whether the presence of the reverse distance effect depends on the familiarity of the sequences being processed. Supporting this proposal, Experiment 1 found that the reverse distance effect was only present when the presented consecutive sequences were considerably more familiar than the presented non-consecutive sequences. Additionally, the sequence 1–2–3 has been suggested to play a pivotal role in the presence of the reverse distance effect due to being both the most familiar and fastest processed sequence. However, it is contested whether 1–2–3 is processed fast because it is familiar or simply because it can typically be verified as ordered from only its first two digits. Supporting the familiarity explanation, Experiments 2 and 3 found that 1–2–3 was processed characteristically fast regardless of whether it could be verified from its first two digits. Taken together, these findings suggest that sequence familiarity plays a critical role in the presence or absence of the reverse distance effect.