bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Selected Ethnic Affiliations in the Development of Post-traumatic Stress Disorder and Other Psychopathology After a Terrorist Bombing in Nairobi, Kenya
Authors: North Carol S. , Dvorkina Tatiana , Thielman Samuel , Pfefferbaum Betty , Narayanan Pushpa , Pollio David E. 
Published: September 2017

AbstractObjectivesDespite the frequency of disasters in Africa, almost nothing is known about ethnic affiliations in relation to psychopathology after such incidents. This study examined the mental health outcomes of members of 7 major ethnic groups exposed to the 1998 terrorist bombing of the US Embassy in Nairobi, Kenya.MethodsApproximately 8 to 10 months after the disaster, 229 civilian employees, 99 locally engaged staff workers of the US State Department and the US Agency for International Development, and 64 workers of the Kenyan Red Cross Society (total N=392) were assessed with the Diagnostic Interview Schedule for the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). Additional data were gathered on demographic characteristics, disaster exposures and injuries, and ethnic affiliations.ResultsDisaster-related post-traumatic stress disorder (PTSD) was significantly less prevalent among members of the Kikuyu group (28%) and post-disaster major depression was significantly more prevalent among members of the Meru group (64%), compared with all others in the sample. Preexisting psychopathology and disaster injury were independently associated with bombing-related psychopathology.ConclusionsFurther study of disaster-related psychopathology in relation to African ethnic affiliations is needed to better understand these associations and to assist in planning resources and interventions for African disaster survivors. (Disaster Med Public Health Preparedness. 2018; 12: 360–365)
UNEXPLORED CONSEQUENCES OF VIOLENCE AGAINST CIVILIANS DURING THE KOREAN WAR
Authors: Kang Woo Chang , Hong Ji Yeon 
Published: September 2017

AbstractIn this paper, we examine the extent to which wartime violence against civilians during the Korean War affects people's current attitudes toward South Korea and other involved countries. Using a difference-in-differences (DID) approach that compares the cohorts born before and after the war, we find that direct exposure to wartime violence induces negative perceptions regarding perpetrator countries. As many of the civilian massacres were committed by the South Korean armed forces, prewar cohorts living in violence-ridden areas during the war demonstrate significantly less pride in South Korea today. In contrast, postwar cohorts from those violent areas, who were exposed to intensive anti-communist campaigns and were incentivized to differentiate themselves from the victims, show significantly greater pride in South Korea, and greater hospitality toward the United States than toward North Korea, compared to prewar cohorts in the same areas and to the same cohorts born in non-violent areas.
Wood14C Dating with AixMICADAS: Methods and Application to Tree-Ring Sequences from the Younger Dryas Event in the Southern French Alps
Authors: Capano Manuela , Miramont Cécile , Guibal Frédéric , Kromer Bernd , Tuna Thibaut , Fagault Yoann , Bard Edouard 
Published: September 2017

AbstractThe AixMICADAS facility is in part dedicated to research on radiocarbon (14C) calibration by means of various archives. For this purpose, we are improving upon the capacity to accurately date subfossil wood. In the current study, nine chemical pretreatment protocols are tested on six wood samples of known ages. The optimization based on14C ages,13C/12C ratios, carbon % and overall mass yield % leads us to favor the acid-base-acid-bleaching pretreatment (ABA-B). This efficient method is shown to provide a residue of holocellulose with optimal blanks equivalent to an age of 51,30014C BP with a standard deviation of 1500 yr based on 25 analyses. The seven wood samples from the Sixth International Radiocarbon Intercomparison (SIRI) are then analyzed as a further verification of the accuracy of our method. As a first scientific contribution, we studied two tree-ring sequences from subfossil pines (Barb12 and Barb17) collected in the southern French Alps. New14C analyses were performed at high resolution (every third year) and are shown to agree well with results obtained previously by high precision β-counting on CO2from large samples at lower resolution for Barb17 and accelerator mass spectrometry (AMS) data for Barb12. The new14C series are then matched to the Kauri and YDB chronologies: the new sequence of Barb12-17 tentatively corresponds to the interval between 12,836 and 12,594 cal BP within the Younger Dryas cold period. The14C comparison between the Barb12-17 sequence from France and the Kauri sequence from New Zealand allows calculating the14C Inter-Hemispheric Gradient (IHG), with an average value of ca. 57 yr. The IHG stayed relatively high throughout the studied period. Interestingly, the IHG exhibits a transient maximum value (ca. 100 yr) during the period of rapid Δ14C rise (12,750–12,720 cal BP), a behavior that could be due to a delayed response of the Southern Hemisphere.
A hidden basidiolichen rediscovered: Omphalina oreades is a separate species in the genus Lichenomphalia (Basidiomycota: Agaricales: Hygrophoraceae)
Authors: LÜCKING Robert , THORN R. Greg , SAAR Irja , PIERCEY-NORMORE Michele D. , MONCADA Bibiana , DOERING Jennifer , MANN Henry , LEBEUF Renée , VOITK Maria , VOITK Andrus 
Published: September 2017

AbstractMolecular studies have shown the type collection of Omphalina oreades to be conspecific with a small brown basidiolichen from the Appalachian range in Newfoundland, both with 4-spored basidia. Two sequences deposited in GenBank, originally identified as O. grisella, fell in the same clade. Sequences of the type collection of Omphalia grisella, with 2-spored basidia, formed a sister clade together with two GenBank deposits, one identified as O. grisella and the other as Omphalina velutina. Omphalina oreades is recombined here as Lichenomphalia oreades comb. nov., and the species redescribed and illustrated. Sequences of the internal transcribed spacer regions of nuclear ribosomal DNA (ITS rDNA) from the algae associated with two collections of L. oreades fell within a highly supported clade with members of an undetermined species of Coccomyxa. The most abundant algal ribosomal large subunit sequence from granules at the base of a different collection matched GenBank sequences identified as Chloroidium ellipsoideum, which is probably either a free-living algal species or a partner to a species of Trapeliopsis. The second most abundant sequence matched Coccomyxa subellipsoidea and is the most likely photobiont of L. oreades. Further studies are required to elucidate the relationship of L. velutina to these taxa.
Hydration traits in cephalolichen members of the epiphytic old forest genusLobaria(s. lat.)
Authors: LONGINOTTI Sara , SOLHAUG Knut Asbjørn , GAUSLAA Yngvar 
Published: September 2017

AbstractThis study aims to quantify the size-dependency of important hydration traits inLobaria amplissima, L. pulmonariaandL. virenssampled in sympatric populations on deciduous tree trunks in southern Norway, and to discuss possible implications of species-specific traits for the ecological niches of these old forest cephalolichens. Traits measured were thallus size (area and mass), specific thallus mass (STM), internal (WHCinternal) and external water-holding capacity (WHCexternal), and water content (WC) after shaking and after blotting.Lobaria amplissimahad the highest WHCinternal, 2·6 times higher thanL. pulmonariawith the lowest WHCinternal. WHCinternal, driven by STM, strongly depended on size. WHCexternalwas 28% (L. virens)to 47% (L. pulmonaria) of the WHCinternal. Unlike WHCinternal, WHCexternaldid not depend on thallus area, meaning that WHCexternalis proportionally higher for smaller compared with larger thalli. The most widespread species,L. pulmonaria, benefits from a flexible hydration strategy due to low STM, facilitating the use of more diverse water sources than the other two species that depend more on rain, particularlyL. amplissimawith the highest STM and thus relatively high WHCinternal. ForL. virens, a combination of less specialized hydration traits and a low tolerance to higher light intensity probably jeopardizes its survival outside rainforest habitats.
Enhancing biodiversity conservation in existing land-use plans with widely available datasets and spatial analysis techniques
Authors: MARTINUZZI SEBASTIAN , RIVERA LUIS , POLITI NATALIA , BATEMAN BROOKE L. , RUIZ DE LOS LLANOS ESTEFANIA , LIZARRAGA LEONIDAS , DE BUSTOS M. SOLEDAD , CHALUKIAN SILVIA , PIDGEON ANNA M. , RADELOFF VOLKER C. 
Published: September 2017

SUMMARYIn many developing countries, high rates of deforestation and biodiversity loss make conservation efforts urgent. Improving existing land-use plans can be an option for enhancing biodiversity conservation. We showcase an approach to enhancing an existing forest land-use plan using widely available data and spatial tools, focusing on Argentina's Southern Yungas ecoregion. We mapped the distribution of wilderness areas and species and habitats of conservation concern, assessed their representation in the land-use plan and quantified potential changes in habitat availability and forest connectivity. Wilderness comprised 48% of the study area, and the highest concentrations of elements of conservation concern were in the north. In the current land-use plan, wilderness areas often occur in regions where logging and grazing are allowed, and a large proportion of the forest with the highest conservation value (43%) is under some level of human influence. Furthermore, we found that deforestation being legally allowed in the land-use plan could reduce forest connectivity and habitat availability substantially. We recommend updating the current land-use plan by considering human influence and elements of conservation concern. More broadly, we demonstrate that widely available spatial datasets and straightforward approaches can improve the usefulness of existing land-use plans so that they more fully incorporate conservation goals.
Physiological attunement in mother–infant dyads at clinical high risk: The influence of maternal depression and positive parenting
Authors: Hendrix Cassandra L. , Stowe Zachary N. , Newport D. Jeffrey , Brennan Patricia A. 
Published: September 2017

AbstractA growing number of research studies have examined the intradyadic coregulation (or attunement) of hypothalamus–pituitary–adrenal axis functioning in mothers and their children. However, it is unclear how early this coregulation may be present in dyads at clinical high risk and whether certain factors, such as maternal depression or positive parenting, are associated with the strength of this coregulation. The present study examined cortisol attunement within mother–infant dyads in a high-risk sample of 233 mothers who received treatment for psychiatric illness during pregnancy and whose infants were 6 months old at the study visit. Results showed that maternal and infant cortisol covaried across four time points that included a stressor paradigm and a mother–infant interaction task. Greater maternal positive affect, but not depression, predicted stronger cortisol attunement. In addition, infants’ cortisol level following separation from the mother predicted mothers’ cortisol level at the next time point. Mothers’ cortisol level following the separation and the laboratory stress paradigm predicted infants’ cortisol levels at each successive time point, over and above infants’ own cortisol at the previous time point. These findings suggest that maternal and infant cortisol levels influence one another in a bidirectional fashion that may be temporally and context dependent.
Beliefs in social inclusion: Invariance in associations among hope, dysfunctional attitudes, and social inclusion across adolescence and young adulthood
Authors: Berry Clio , Greenwood Kathryn 
Published: September 2017

AbstractSocial disability in youth is an important precursor of long-term social and mental health problems. Social inclusion is a key policy driver and fits well within a new paradigm of health and well-being rather than illness-oriented services, yet little is known about social inclusion and its facilitators for “healthy” young people. We present a novel exploratory structural analysis of social inclusion using measures from 387 14- to 36-year-olds. Our model represents social inclusion as comprising social activity and community belonging, with both domains predicted by hopeful and dysfunctional self-beliefs but hopefulness more uniquely predicting social inclusion in adolescence. We conclude that social inclusion can be modeled for meaningful comparison across spectra of development, mental health, and functioning.
Effects of Process and Outcome Accountability on Idea Generation
Authors: Häusser Jan Alexander , Frisch Johanna Ute , Wanzel Stella , Schulz-Hardt Stefan 
Published: September 2017

Abstract. Previous research on the effects of outcome and process accountability on decision making has neglected the preceding phase of idea generation. We conducted a 2 (outcome accountability: yes vs. no) × 2 (process accountability: yes vs. no) experiment (N = 147) to test the effects of accountability on quantity and quality of generated ideas in a product design task. Furthermore, we examined potential negative side effects of accountability (i.e., stress and lengthened decision making). We found that (a) outcome accountability had a negative effect on quantity of ideas and (b) process accountability extended the idea generation process. Furthermore, any type of accountability (c) had a negative effect on uniqueness of ideas, (d) did not affect the quality of the idea that was selected, and (e) increased stress. Moreover, the negative effect of accountability on uniqueness of ideas was mediated by stress.
Towards individualized diagnostics of biofilm-associated infections: a case study
Authors: Müsken Mathias , Klimmek Kathi , Sauer-Heilborn Annette , Donnert Monique , Sedlacek Ludwig , Suerbaum Sebastian , Häussler Susanne 
Published: September 2017

AbstractOrganized within biofilm communities, bacteria exhibit resistance towards a broad spectrum of antibiotics. Thus, one might argue that bacteria isolated from biofilm-associated chronic infections should be subjected to resistance profiling under biofilm growth conditions. Various test systems have been developed to determine the biofilm-associated resistance; however, it is not clear to what extent the in vitro results reflect the situation in vivo, and whether the biofilm-resistance profile should guide clinicians in their treatment choice. To address this issue, we used confocal microscopy in combination with live/dead staining, and profiled biofilm-associated resistance of a large number (>130) of clinical Pseudomonas aeruginosa isolates from overall 15 cystic fibrosis patients. Our results demonstrate that in addition to a general non-responsiveness of bacteria when grown under biofilm conditions, there is an isolate-specific and antibiotic-specific biofilm-resistance profile. This individual resistance profile is independent on the structural properties of the biofilms. Furthermore, biofilm resistance is not linked to the resistance profile under planktonic growth conditions, or a mucoid, or small colony morphology of the tested isolates. Instead, it seems that individual biofilm structures evolve during biofilm-associated growth and are shaped by environment-specific cues. In conclusion, our results demonstrate that biofilm resistance profiles are isolate specific and cannot be deduced from commonly studied phenotypes. Further clinical studies will have to show the added value of biofilm-resistance profiling. Individualized diagnosis of biofilm resistance might lead to more rational recommendations for antimicrobial therapy and, thus, increased effectiveness of the treatment of chronically infected patients.
OsSIZ2 exerts regulatory influences on the developmental responses and phosphate homeostasis in rice
Authors: Pei Wenxia , Jain Ajay , Sun Yafei , Zhang Zhantian , Ai Hao , Liu Xiuli , Wang Huadun , Feng Bing , Sun Rui , Zhou Hongmin , Xu Guohua , Sun Shubin 
Published: September 2017

AbstractOsSIZ1, a small ubiquitin-related modifier (SUMO) E3 ligase, exerts regulatory influences on the developmental responses and phosphate (Pi) homeostasis in rice (Oryza sativa). Whether paralogs OsSIZ1 and OsSIZ2 are functionally redundant or the latter regulates these traits independent of the former is not known. To determine this, in this study, OsSIZ2 was functionally characterized by employing reverse genetic approaches. Although the relative expression of OsSIZ2 was spatiotemporally regulated, it showed constitutive expression in root and leaf blade irrespective of Pi regime. Analysis of T-DNA insertion knockout (ossiz2) and RNAi-mediated knockdown (Ri1-3) mutants revealed positive influences on growth and developmental responses including yield-related traits. On the contrary, these mutants exhibited negative effects on the concentrations of Pi and total P in different tissues. The relative expression levels of some of the genes that are involved in Pi sensing and signaling cascades were differentially modulated in the mutants. Further, attenuation in the expression levels of OsSIZ2 in the roots of ossiz1 and relatively similar trend of the effects of the mutation in OsSIZ1 and OsSIZ2 on growth and development and total P concentration in different tissues suggested a prevalence of partial functional redundancy between these paralogs.
GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro
Authors: Amano Masayuki , Miguel Salcedo-Gómez Pedro , Yedidi Ravikiran S. , Delino Nicole S. , Nakata Hirotomo , Venkateswara Rao Kalapala , Ghosh Arun K. , Mitsuya Hiroaki 
Published: September 2017

AbstractWe report that GRL-09510, a novel HIV-1 protease inhibitor (PI) containing a newly-generated P2-crown-tetrahydrofuranylurethane (Crwn-THF), a P2′-methoxybenzene, and a sulfonamide isostere, is highly active against laboratory and primary clinical HIV-1 isolates (EC50: 0.0014–0.0028 μM) with minimal cytotoxicity (CC50: 39.0 μM). Similarly, GRL-09510 efficiently blocked the replication of HIV-1NL4-3 variants, which were capable of propagating at high-concentrations of atazanavir, lopinavir, and amprenavir (APV). GRL-09510 was also potent against multi-drug-resistant clinical HIV-1 variants and HIV-2ROD. Under the selection condition, where HIV-1NL4-3 rapidly acquired significant resistance to APV, an integrase inhibitor raltegravir, and a GRL-09510 congener (GRL-09610), no variants highly resistant against GRL-09510 emerged over long-term in vitro passage of the virus. Crystallographic analysis demonstrated that the Crwn-THF moiety of GRL-09510 forms strong hydrogen-bond-interactions with HIV-1 protease (PR) active-site amino acids and is bulkier with a larger contact surface, making greater van der Waals contacts with PR than the bis-THF moiety of darunavir. The present data demonstrate that GRL-09510 has favorable features for treating patients infected with wild-type and/or multi-drug-resistant HIV-1 variants, that the newly generated P2-Crwn-THF moiety confers highly desirable anti-HIV-1 potency. The use of the novel Crwn-THF moiety sheds lights in the design of novel PIs.
ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation
Authors: Bessonnard Sylvain , Coqueran Sabrina , Vandormael-Pournin Sandrine , Dufour Alexandre , Artus Jérôme , Cohen-Tannoudji Michel 
Published: September 2017

AbstractInner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated Kinase (ERK) signaling pathway. Here, we have analyzed in details the kinetics of specification and found that ICM cell responsiveness to the up and down regulation of FGF signaling activity are temporally distinct. We also showed that PrE progenitors are generated later than Epi progenitors. We further demonstrated that, during this late phase of specification, a 4 hours period of FGF/ERK inhibition prior E3.75 is sufficient to convert ICM cells into Epi. Finally, we showed that ICM conversion into Epi in response to inhibition during this short time window requires both transcription and proteasome degradation. Collectively, our data give new insights into the timing and mechanisms involved in the process of ICM specification.
Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia
Authors: Carabia Júlia , Carpio Cecilia , Abrisqueta Pau , Jiménez Isabel , Purroy Noelia , Calpe Eva , Palacio Carles , Bosch Francesc , Crespo Marta 
Published: September 2017

AbstractChronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironment, being the BCR pathway one key player in this crosstalk. Among proteins participating, ZAP-70 enhances response to microenvironmental stimuli. MicroRNA-21 (miR-21) is overexpressed in diverse neoplasias including CLL, where it has been associated to refractoriness to fludarabine and to shorter time to progression and survival. To further elucidate the role of ZAP-70 in the biology of CLL, we studied its involvement in miR-21 regulation. MiR-21 expression was higher in CLL cells with high ZAP-70. Ectopic expression of ZAP-70 induced transcription of miR-21 via MAPK and STAT3, which subsequently induced downregulation of tumor suppressors targeted by miR-21. The co-culture of primary CLL cells mimicking the microenvironment induced ZAP-70 and miR-21 expression, as well as downregulation of miR-21 targets. Interestingly, the increase in miR-21 after co-culture was significantly impaired by ibrutinib, indicating that the BCR signaling pathway is involved in its regulation. Finally, survival of CLL cells induced by the co-culture correlated with miR-21 upregulation. In conclusion, stimuli from the microenvironment regulate miR-21 and its targeted tumor suppressor genes via a signaling pathway involving ZAP-70, thus contributing to the cytoprotection offered by the microenvironment particularly observed in CLL cells expressing ZAP-70.
Use of antimicrobial peptides as a feed additive for juvenile goats
Authors: Liu Qi , Yao Shuhua , Chen Yun , Gao Shuang , Yang Yanyi , Deng Junliang , Ren Zhihua , Shen Liuhong , Cui Hengmin , Hu Yanchun , Ma Xiaoping , Yu Shumin 
Published: September 2017

AbstractAlthough antimicrobial peptides (AMPs) have been used as feed additives, only a few studies have examined their use in ruminants. In this study, we evaluated the use of AMPs(recombinant swine defensin and a fly antibacterial peptide were mixed by 1:1) as a medicated feed additive for juvenile goats. Dietary treatments included control groups (group I: 300 g concentrate; group III: 600 g concentrate), and AMP-supplemented groups (group II: 300 g concentrate + 3.0 g AMPs; group IV: 600 g concentrate + 3.0 g AMPs). AMP-treated groups exhibited an increase in bacterial genera, including Fibrobacter, Anaerovibrio, and Succiniclasticum, and the ciliate genus Ophryoscolex; as well a reduction in bacterial genera, such as Selenomonas, Succinivibrio, and Treponema, and the ciliate genera Polyplastron, Entodinium, and Isotricha. The changes in Fibrobacter, Anaerovibrio, Ophryoscolex, Polyplastron, Entodinium, and Isotricha were related to the concentrate. AMP treatment led to increased body weight, average daily weight gain, enzymatic activity (pectinase, xylanase, and lipase), especially in the normal concentrate group, and influence on ruminal fermentation function. In addition, goats treated with AMPs had higher rumen microorganism diversity indices than the control groups. Our results demonstrate that AMPs can be utilized as feed additives for juvenile goats.