bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrastriatal Transplantation of Human Neural Stem Cells Restores the Impaired Subventricular Zone in Parkinsonian Mice
Authors: Zuo Fuxing , Xiong Feng , Wang Xia , Li Xueyuan , Wang Renzhi , Ge Wei , Bao Xinjie 
Published: March 2017

Abstract
Cell replacement therapy using neural stem cells (NSCs) transplantation has recently emerged as a promising method of Parkinson's disease (PD) treatment; however, the underlying mechanisms are not fully understood. To gain new insights into the mechanisms of 6-hydroxydopamine (6-OHDA)-induced lesioning and therapeutic efficacy of human NSCs (hNSCs) transplantation, the striatum (ST) of intrastriatal 6-OHDA-injected parkinsonian mice were unilaterally engrafted with undifferentiated hNSCs. A high-throughput quantitative proteomic approach was used to characterize the proteome profiles of PD-related brain regions such as the SN, ST, olfactory bulb, and subventricular zone (SVZ) in these mice. The abundance of more than 5,000 proteins in each region was determined with high confidence in this study, which is the most extensive proteomic study of PD mouse models to date. In addition to disruption of the DA system, the quantitative analysis demonstrated profound disturbance of the SVZ proteome after 6-OHDA insult. After hNSC engraftment, the SVZ proteome was restored and the astrocytes in the ST were greatly activated, accompanied by an increase in neurotrophic factors. Furthermore, bioinformatics analysis demonstrated that the changes in the proteome were not caused by the proliferation of hNSCs or their progeny, but rather by the reaction of endogenous stem cells. Overall, this study elucidates the unexpected role of SVZ cells in PD progress and treatment, thereby providing new therapeutic targets for PD.
Risk Factors for Postoperative Ascites in Patients Undergoing Liver Resection for Hepatocellular Carcinoma
Authors: Yoshikawa Takahiro , Nomi Takeo , Hokuto Daisuke , Yasuda Satoshi , Kawaguchi Chihiro , Yamada Takatsugu , Kanehiro Hiromichi , Nakajima Yoshiyuki 
Published: March 2017

AbstractBackgroundPostoperative ascites is a common complication after liver resection. This study aimed to identify the risk factors for ascites in patients after liver resection and the relationship between postoperative ascites and other complications.MethodsWe retrospectively analyzed data that were obtained from 266 patients who underwent liver resection for treating hepatocellular carcinoma between 2008 and 2015. Postoperative ascites was defined as a daily ascitic fluid drainage exceeding 500 mL on postoperative day 3 or later. The participants were categorized and analyzed with respect to the presence or absence of postoperative ascites.ResultsOverall, 17 (6.4%) patients developed postoperative ascites. A multivariate analysis identified that three significant factors—serum albumin, platelet count, and operation duration—were associated with the development of postoperative ascites. Sixteen (94.1%) of the 17 patients with postoperative ascites experienced other associated complications. The patients with ascites had more pleural effusion (70.6 vs. 17.7%, P < 0.001) than the patients without ascites. Postoperative morbidity, except for pleural effusion, was similar between the groups. The postoperative hospital stay duration was significantly longer in patients with ascites than in those without ascites.ConclusionsPostoperative ascites frequently occurred in patients with decreased liver functional reserve. Moreover, the presence of ascites was associated with significantly increased pleural effusion rates, and postoperative hospital stay duration was significantly prolonged.
A Psychological Perspective on Factors Predicting Prophylactic Salpingo‐Oophorectomy in a Sample of Italian Women from the General Population. Results from a Hypothetical Study in the Context of BRCA Mutations
Authors: Gavaruzzi Teresa , Tasso Alessandra , Franiuk Marzena , Varesco Liliana , Lotto Lorella 
Published: March 2017

AbstractThe aim of this study was to assess attitudes toward ovarian cancer risk management options for BRCA mutation carriers in healthy Italian women, and to identify predictors of the preference for risk reducing salpingo‐oophorectomy (RRSO) over surveillance. One hundred eighty‐one women aged 30–45 completed a questionnaire about preferences, knowledge, risk perception, and socio‐demographic information. Participants were randomly presented with a pamphlet about BRCA1 or BRCA2 mutation‐specific testing, consequences of testing and preventive options for carriers, and they were stratified by having children or not and by age group. Surveillance was the preferred option (64.6%), followed by RRSO (24.3%). Although RRSO is the only effective strategy available to BRCA carriers, most healthy women faced for the first time with this option may not consider it as their preferred choice. Predictors associated with a higher likelihood to prefer surgery over surveillance were: knowing that life expectancy is longer with surgery, perceived comprehension of the consequences of testing, previous knowledge about BRCA testing, anticipated worry about developing cancer, and feelings of risk. Childbearing intentions and the effect of childbearing intentions on choice were associated with a lower preference for surgery. Further research is needed to confirm the role of the factors identified in this study in order to promote informed decision‐making about RRSO.
New Evidence Against a Causal Marriage Wage Premium
Authors: Killewald Alexandra , Lundberg Ian 
Published: March 2017

AbstractRecent research has shown that men’s wages rise more rapidly than expected prior to marriage, but interpretations diverge on whether this indicates selection or a causal effect of anticipating marriage. We seek to adjudicate this debate by bringing together literatures on (1) the male marriage wage premium; (2) selection into marriage based on men’s economic circumstances; and (3) the transition to adulthood, during which both union formation and unusually rapid improvements in work outcomes often occur. Using data from the National Longitudinal Survey of Youth 1979, we evaluate these perspectives. We show that wage declines predate rather than follow divorce, indicating no evidence that staying married benefits men’s wages. We find that older grooms experience no unusual wage patterns at marriage, suggesting that the observed marriage premium may simply reflect co-occurrence with the transition to adulthood for younger grooms. We show that men entering shotgun marriages experience similar premarital wage gains as other grooms, casting doubt on the claim that anticipation of marriage drives wage increases. We conclude that the observed wage patterns are most consistent with men marrying when their wages are already rising more rapidly than expected and divorcing when their wages are already falling, with no additional causal effect of marriage on wages.
Taking a break in response to pain. An experimental investigation of the effects of interruptions by pain on subsequent activity resumption
Authors: Gatzounis Rena , Schrooten Martien G.S. , Crombez Geert , Vancleef Linda M.G. , Vlaeyen Johan W.S. 
Published: March 2017

Abstract

Background and aims
Interrupting ongoing activities with the intention to resume them again later is a natural response to pain. However, such interruptions might have negative consequences for the subsequent resumption and performance of the interrupted activity. Activity interruptions by pain may be more impairing than interruptions by non-painful stimuli, and also be subjectively experienced as such. These effects might be more pronounced in people high in pain catastrophizing. These hypotheses were investigated in two experiments.

Methods
In Experiment 1, healthy volunteers (n = 24) performed an ongoing task requiring a sequence of joystick movements. Occasionally, they received either a painful electrocutaneous or a non-painful vibrotactile stimulus, followed by suspension of the ongoing task and temporary engagement in a different task (interruption task). After performing the interruption task for 30 s, participants resumed the ongoing task. As the ongoing task of Experiment 1 was rather simple, Experiment 2 (n = 30) included a modified, somewhat more complex version of the task, in order to examine the effects of activity interruptions by pain.

Results
Participants made more errors and were slower to initiate movements (Experiment 1 & 2) and to complete movements (Experiment 2) when they resumed the ongoing task after an interruption, indicating that interruptions impaired subsequent performance. However, these impairments were not larger when the interruption was prompted by painful than by non-painful stimulation. Pain catastrophizing did not influence the results.

Conclusions
Results indicate that activity interruptions by pain have negative consequences for the performance of an activity upon its resumption, but not more so than interruptions by non-painful stimuli. Potential explanations and avenues for future research are discussed.

Implications
Interrupting ongoing activities is a common response to pain. In two experiments using a novel paradigm we showed that activity interruptions by pain impair subsequent activity resumption and performance. However, this effect seems to not be specific to pain.
Social Networks and Networked Scholars
Authors: Pluckhahn Thomas J. , Wallis Neill J. 
Published: March 2017

ABSTRACTWe describe the development of an open-access database for Swift Creek Complicated Stamped ceramics, a type of pottery common to Georgia, eastern Alabama, and northern Florida in the Middle and Late Woodland periods between ca. cal A.D. 100 and 800. The characteristic stamped designs on Swift Creek pottery, created by impressing a carved paddle into a clay vessel before firing, provide unique signatures that enable archaeologists to identify paddle matches—multiple vessels, sometimes hundreds of kilometers apart, stamped with a single paddle. These paddle matches potentially allow archaeologists to trace social interactions across hundreds of kilometers with high spatial and temporal resolution. To date, however, this potential has been hindered by the limited accessibility and fragmented nature of the dataset of reconstructed designs. The database we describe integrates paddle designs with other pertinent data for identifying paddle matches and their context, including the results of sourcing and technofunctional analyses and absolute dating. We view this database not only as a critical component of our own research, but also as a platform for collaboration among researchers that will facilitate broad syntheses of the region.
Changes of glaciers and glacial lakes implying corridor-barrier effects and climate change in the Hengduan Shan, southeastern Tibetan Plateau
Authors: WANG XIN , CHAI KAIGUO , LIU SHIYIN , WEI JUNFENG , JIANG ZONGLI , LIU QIONGHUAN 
Published: March 2017

ABSTRACTChanges of glaciers and glacial lakes and their causes were examined in the Hengduan Shan from 1990 to 2014, based on Landsat TM/ETM+/OLI images. A total glacier area of 1298.8 ± 62.1 km2 and glacial lake area of 255.8 ± 31.6 km were inventoried in 2014. The area of glaciers declined at an average rate of −0.40 ± 0.26% a−1, while glacial lakes expanded at average rate of +0.12 ± 0.03% a−1 over the past 24 years. These changes probably resulted from an observable temperature increase and slight precipitation increase. A ‘corridor-barrier’ effect formed by the longitudinal range–gorge terrain may have had major impacts on the distributions and changes of glaciers and glacial lakes. The Ningjing-Yunling Shan, where glaciers and glacial lakes are sparsely distributed, are an important geographic transition line in the Hengduan Shan because of the barrier effect of the mountain ranges against moisture from the southwest. In contrast, between the south and north, there were small differences with respect to the distributions and changes of glaciers and glacial lakes, owing to a north–south corridor effect for water and heat transport and diffusion through the longitudinal gorges in the Hengduan Shan.
Evolutionary implications of a new transitional blastozoan echinoderm from the middle Cambrian of the Czech Republic
Authors: Nardin Elise , Lefebvre Bertrand , Fatka Oldřich , Nohejlová Martina , Kašička Libor , Šinágl Miroslav , Szabad Michal 
Published: March 2017

AbstractThe primitive blastozoanFelbabkacystis luckaen. gen. n. sp. is described from the Drumian Jince Formation, Barrandian area (Czech Republic) from eleven fairly well-preserved specimens. Its unique body plan organization is composed of a relatively long, stalk-like imbricate structure directly connected to the aboral imbricate cup of the test and of an adoral vaulted tessellate test supporting the ambulacral and brachiolar systems. Its bipartite test, called prototheca, highlights the evolution of the body wall among blastozoans.Felbabkacystisn. gen. shows the combination of plesiomorphic (imbricate stalk-like appendage) and derived features (highly domed peristome, elongate epispires). The new genus is interpreted as a transitional form between calyx-bearing and theca-bearing blastozoans, and is attributed to the new family Felbabkacystidae. The lithology, the associated fauna, and the possession of a long stalk suggest thatFelbabkacystiswas probably a low-level suspension feeder living in relatively deep settings.
Stable Carbon Isotopic Composition in Annual Rings of a Pine Tree (Pinus Densiflora) from Yeongwol, Korea: Possible Application to Climate Study
Authors: Kim Chi-Hwan , Lee Jang Hoon , Kang Jin , Song Sujin , Yun Myung-ho , Kim Jong Chan 
Published: March 2017

AbstractStable carbon isotope ratios were measured on the alpha-cellulose in tree rings of a pine tree (Pinus densiflora) from Yeongwol, Korea. We developed an annual-resolution δ13C series (1835–1905) by correcting the measured data for changes in δ13C of air to minimize non-climatic influences. To investigate the climatic signal in the δ13C series, we performed correlation analysis between δ13C and the Cheugugi climate data. The Cheugugi precipitation data were first recorded by King Sejong (1397–1450) of the Joseon Dynasty. However, the longest set of precipitation data available is the one collected in Seoul (1776–1907). Although many studies support the reliability of the Cheugugi data, no previous studies have investigated the potential of the δ13C signal in tree rings as paleoclimate proxy using the Cheugugi data. Recent precipitation trends in Yeongwol are quite similar to that of Seoul, and we found significant correlations between the Cheugugi data and the δ13C series. We suggest further studies to replicate these results and confirm whether comparing δ13C variations in tree rings and Cheugugi data is a useful method of investigating the potential of the δ13C signal as a paleoclimate proxy in or near the Korean peninsula.
Insecticidal effects of extracts of Humulus lupulus (hops) L. cones and its principal component, xanthohumol
Authors: Aydin T. , Bayrak N. , Baran E. , Cakir A. 
Published: March 2017

AbstractInsecticidal effects of the dichloromethane, ethyl acetate, acetone, ethanol and methanol extracts of Humulus lupulus (hops) L. cones and its principal components, xanthohumol was investigated on five stored pests, Sitophilus granarius (L.), Sitophilus oryzae (L.), Acanthoscelides obtectus (Say.), Tribolium castaneum (Herbst) and Lasioderma serricorne (F.). The mortality of adults of the insects treated with 2, 5, 5, 10 and 20 mg ml̠−1 concentrations of the extracts and xanthuhumol was counted after 24, 48, 72, 96 and 120 h. In order to determine the toxic effects of the substances tested against all tested insects, durations for 50% mortality of the adults, and LD50 values were also determined in the first 48 h by probit analysis. Our results also showed that xanthohumol was more toxic against the pests in comparison with the extracts applications. LD50 values for xanthohumol were found to be low dose as compared with the extracts. Xanthohumol was more toxic against S. granarius (L.) with 6.8 µg of LD50 value. Among the extracts, methanol extract was less effective than other extracts against all tested insects. The ethyl acetate extract of H. lupulus cones was the most effective extract against the tested pests. The quantitative amounts of xanthohumol in the extracts were determined using a high-performance liquid chromatography. The quantitative data indicated that amount of xanthohumol in the extracts increased with increase of polarity of the solvents used from methanol to dichloromethane. The methanol extract contained the high amount of xanthohumol with 5.74 g/100 g extract (0.46 g/100 g plant sample).
Dionysos in Jerusalem and the Historicity of 2 Macc 6:7
Authors: Amitay Ory 
Published: March 2017

In his masterful translation and commentary on the Second Book of Maccabees, Daniel Schwartz devotes a short appendix to the historicity of the information provided in chapter 6, verse 7:ἤγοντο δὲ μετὰ πικρᾶς ἀνάγκης εἰς τὴν κατὰ μῆνα τοῦ βασιλέως γενέθλιον ἡμέραν ἐπὶ σπλαγχισμόν, γενομένης δὲ Διονυσίων ἑορτῆς ἠναγκάζοντο κισσοὺς ἔχοντες πομπεύειν τΔιονύσῳ.And with bitter compulsion they were led each month to a banquet for the King's birthday, and as there was a Dionysia festival, they were forced to parade carrying ivy in honor of Dionysos.In the opening paragraph of his discussion of the verse, Schwartz states: “This verse refers to two elements in Antiochus’ persecution in Jerusalem: monthly celebrations of the king's birthday and the cult of Dionysus. Concerning both there is room to suspect that they reflect the Ptolemaic context of our author more than the realities of Seleucid Jerusalem.” In other words, he doubts the historicity of the information provided in the verse, making it an imaginative creation either by Jason of Kyrene or by the anonymous redactor of 2 Macc.
Secondary nucleation of monomers on fibril surface dominatesα-synuclein aggregation and provides autocatalytic amyloid amplification
Authors: Gaspar Ricardo , Meisl Georg , Buell Alexander K. , Young Laurence , Kaminski Clemens F. , Knowles Tuomas P. J. , Sparr Emma , Linse Sara 
Published: March 2017

AbstractParkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containingα-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence of the aggregation rate on monomer concentration. The molecular mechanism underlying this process could be nucleation of monomers on fibril surfaces or fibril fragmentation. Here, we aim to distinguish between these mechanisms. The nature of the secondary processes was investigated using differential sedimentation analysis, trap and seed experiments, quartz crystal microbalance experiments and super-resolution microscopy. The results identify secondary nucleation of monomers on the fibril surface as the dominant secondary process leading to rapid generation of new aggregates, while no significant contribution from fragmentation was found. The newly generated oligomeric species quickly elongate to further serve as templates for secondary nucleation and this may have important implications in the spreading of PD.
Dispersal ofGoeppertia marantifoliaclonal offspring increases with greater canopy openness and larger plant size
Authors: Matlaga David P. , Snyder Rachel K. , Horvitz Carol C. 
Published: March 2017

Abstract:Many plants within the neotropical understorey produce both seeds and clonal offspring. Plant attributes (i.e. size) and variability in light can influence seed dispersal but it is not known if these factors influence the dispersal of clonal offspring. Our goal was to determine if canopy openness and plant size influence clonal-offspring dispersal of the herbGoeppertia marantifolia, which produces clonal bulbils on above-ground shoots. We monitored plants in permanent plots with varying levels of canopy openness in Corcovado National Park, Costa Rica. We recorded canopy openness, leaf area and the distance clonal offspring travelled from their parent plant (N = 283). Our path analysis model demonstrated that canopy openness had a strong positive effect on dispersal distance, while the association between clonal-offspring dispersal distance and parent plant leaf area was only weakly positive. On average, plants experiencing high canopy openness dispersed their clonal offspring further than plants under low canopy openness (124 cm vs. 79 cm, respectively). Contrary to studies on species that utilize rhizomes and stolons for clonal reproduction, we found that in this bulbil-producing species light availability is positively associated with clonal dispersal distance. Therefore, the influence of resource availability on spatial population dynamics of clonal species may be influenced by the species’ growth-form.
First record of flower visitation by a rodent in Neotropical Proteaceae, Oreocallis grandiflora
Authors: Cárdenas Santiago , Nivelo-Villavicencio Carlos , Cárdenas Juan D. , Landázuri P. Omar , Tinoco Boris A. 
Published: March 2017

Abstract:There is still much to learn about pollination ecology in areas of high species diversity, such as the Neotropical region. For example, the role of non-flying mammals in pollination is largely unknown in the Neotropical areas, despite the importance of this group in the pollination of plants in other regions. Here we report evidence for flower visitation by a rodent to Oreocallis grandiflora (Proteaceae) in our study site in the southern Andes of Ecuador. For a period of 241 h, camcorders equipped with infrared lights revealed 22 occurrences of floral visitation by Microryzomys altissimus (Cricetidae) to inflorescences of O. grandiflora. Pollen samples taken from the fur of captured individuals showed that M. altissimus carries pollen of O. grandiflora, indicating a potential pollinator role for the rodent. This is the first record of flower visitation by a rodent in the Neotropical Andes. Pollination interactions between non-flying mammals and Proteaceae have been reported in other southern hemisphere continents. This study underscores the need for more research on pollination interactions in the Neotropics, especially in critical Andean biodiversity hotspots.
Effect of distance from edge on exotic grass abundance in tropical dry forests bordering pastures in Ecuador
Authors: Lyons-Galante Hannah Ruth , Haro-Carrión Xavier 
Published: March 2017

Abstract:We compared exotic pasture grass cover near the edges of 20–25-y-old secondary forests (N = 8) with those of mature forests (N = 8), bordering actively grazed pastures on the Pacific Coast of Ecuador. We estimated grass cover in 224 1 × 3-m plots along transects that ran from the pasture edge into forest interiors (11–44 m). Using a spline regression, we divided the transects into three segments: exterior (in the pasture), edge and interior (in the forest). With a stepwise regression, we tested the effect of transect section, forest type and distance from edge on grass cover. Forest type, distance from edge, interior transect section and the combined effect of distance from edge in both the interior and exterior sections explained variation in grass cover. Grass abundance was higher and penetrated further into secondary than mature forests. Edge proximity and differences in forest canopy openness likely favours recruitment and persistence of pasture grasses.