bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ganzheitliche Regelung der Energieeffizienz
Authors: Heimann Oliver , Thiele Gregor 
Published: May 2017

Kurzfassung
Im Rahmen des in diesem Beitrag beschriebenen Projekts werden neue Ansätze zur mitlaufenden Energieeffizienzoptimierung industrieller Anlagen erforscht. Hierzu entsteht ein flexibles Modell zur Anlagenbeschreibung. Modellbildung und Adaption sind hierbei für einfache Übertragbarkeit möglichst unabhängig vom A-Priori-Wissen zu gestalten. Verschiedene Modellvarianten und Optimierungsverfahren werden im eigens entwickelten Framework evaluiert und vor dem Hintergrund der Energieeffizienz-Kennzahlen diskutiert.
Vision wird Wirklichkeit
Authors: Zeeb Hartmut 
Published: May 2017

Kurzfassung
Die 16. Ulmer Gespräche bescherten der Ingenics AG einen neuen Besucherrekord. Hochkarätige Expertenvorträge und Diskussionen trugen zum besseren Verständnis von Digitalisierung und Industrie 4.0 bei, da am Beispiel von erfolgreichen Projekten der Nutzen deutlich gemacht wurde. Ingenics konnte sich einmal mehr als Partner für innovative Unternehmungen im Zusammenhang mit der digitalen Transformation von Montage, Produktion, Logistik und Services empfehlen.
Die Lean Factory
Authors: Quasdorff Olaf , Bracht Uwe 
Published: May 2017

Kurzfassung
Die Lean Production gilt als „State of the Art“ für effiziente Fabriken. Zusätzlich hat die beispiellose Entwicklung der Informationstechnologie im Allgemeinen und die der Digitalen Fabrik im Besonderen wesentlichen Einfluss auf die Produkt- und Produktionsgestaltung. Lean Production und Digitale Fabrik können durch den konsequenten Einsatz von systemevidenten Elementen die notwendigen Voraussetzungen für eine Symbiose und damit für umfassende Effizienzsteigerungen schaffen.
Quantitative Erfassung externer Unsicherheiten bei der Gestaltung von Produktionsnetzwerken
Authors: Schuh Günther , Prote Jan-Philipp , Schmitz Torben , Nett Sebastian 
Published: May 2017

Kurzfassung
Entscheidungen über die Gestaltung von Produktionsnetzwerken stellen eine besondere Herausforderung dar. Mögliche Netzwerkalternativen müssen dabei für zukünftige Zeitpunkte bewertet werden, wobei Unsicherheiten hinsichtlich externer Faktoren wie Preis- oder Lohnentwicklungen zu berücksichtigen sind. Dieser Beitrag stellt daher einen quantitativen Ansatz zur Unsicherheitsbewertung vor. Mögliche Entwicklungen externer Faktoren werden durch die Bewertung konsistenter Szenarien in ein Unsicherheitsmaß überführt.
Lean Product Development und radikale Innovationen
Authors: Trapp Stefan , Warschat Joachim 
Published: May 2017

Kurzfassung
Lean Product Development ist ein in der Unternehmenspraxis derzeit sehr populärer Ansatz, um Entwicklungsprozesse effektiver und effizienter zu gestalten. In diesem Beitrag wird gezeigt, dass Lean Product Development seine Berechtigung vorwiegend in der Entwicklungsphase des Innovationsprozesses hat. Die vorausgehenden frühen Innovationsphasen, die entscheidend für die Hervorbringung hochgradiger Innovationen sind, erfordern andere Methoden, um eine potenziell gefährliche Überbetonung exploitativer Innovationen zu vermeiden.
Lean Service Assessment
Authors: Dombrowski Uwe , Adams Tim , Thiel Frederic 
Published: May 2017

Kurzfassung
Ganzheitliche Produktionssysteme (GPS) haben das Potenzial, die Gewinnmargen und die Kundenzufriedenheit im After Sales Service zu erhöhen. Dies gilt insbesondere für hochwertige Investitionsgüter aufgrund ihrer langen Produktlebenszyklen und eines hohen manuellen Serviceaufwands bei überwiegend planbaren Instandhaltungszyklen. Prägnante Beispiele sind Flugzeug- oder Schienenfahrzeugsysteme. Um eine kontinuierliche Effizienzsteigerung in der Serviceerbringung sicherzustellen, ist es entscheidend, das bestehende Produktionssystem nachhaltig und zielgerichtet weiter zu verbessern. Bei der Identifikation von Verbesserungspotenzialen hilft eine Bewertungssystematik, die den Ist-Zustand des GPS zeigt und Verbesserungsmaßnahmen für bestehende Defizite ableitet. Im Produktionsumfeld wird hierfür das GPS-Assessment eingesetzt. Anhand eines Praxisbeispiels aus der Instandhaltung von Straßenbahnen wird untersucht, ob das GPS-Assessment auch im Serviceumfeld die Möglichkeit bietet, kurzfristig den Umsetzungsstand eines unternehmensspezifischen GPS zu bewerten und Verbesserungspotenziale abzuleiten.
Nachhaltiges Gebäude mit LED-Beleuchtung
Authors: Weidenfeld Silke 
Published: May 2017

Kurzfassung
Entsprechend der eigenen Unternehmensphilosophie setzte das Medizintechnikunternehmen Medwork aus dem mittelfränkischen Höchstadt bei der Erstellung seines Neubaus auf Nachhaltigkeit und Produkte „Made in Germany”. Sämtliche Beleuchtungslösungen wurden konsequent auf LED umgestellt. Die Wahl fiel sowohl für die Fertigung als auch die Büros auf effiziente Lichtlösungen von Waldmann. Der Leuchtenhersteller überzeugte mit kompetenter Beratung und hochwertiger Beleuchtung Made in Germany.
A Higher Rate of Iron Deficiency in Obese Pregnant Sudanese Women
Authors: Abbas Wisal , Adam Ishag , Rayis Duria A. , Hassan Nada G. , Lutfi Mohamed F. 
Published: May 2017

AIM: To assess the association between obesity and iron deficiency (ID).MATERIAL AND METHODS: Pregnant women were recruited from Saad Abualila Hospital, Khartoum, Sudan, during Januaryâ€“April 2015. Medical history (age, parity, gestational age) was gathered using questionnaire. Â Weight and height were measured, and body mass index (BMI) was calculated. Women were sub-grouped based on BMI into underweight (< 18.5 kg/m^2), normal weight (18.5â€“24.9 kg/m^2), overweight (25â€“29.9 kg/m^2) and obese (â‰¥ 30 kg/m^2). Serum ferritin and red blood indices were measured in all studied women.RESULTS: Two (0.5%), 126 (29.8%), 224 (53.0%) and 71 (16.8%) out of the 423 women were underweight, normal weight, overweight and obese, respectively. Anemia (Hb <11 g/dl), ID (ferritin <15Âµg/l) and iron deficiency anemia (IDA) were prevalent in 57.7%, 21.3% and 12.1%, respectively. Compared with the women with normal BMI, significantly fewer obese women were anemic [25 (35.2%) vs. 108 (85.7%), P < 0.001] and significantly higher number of obese women [25 (35.2) vs. 22 (17.5, P = 0.015] had iron deficiency. Linear regression analysis demonstrated a significant negative association between serum ferritin and BMI (â€“ 0.010 Âµg/, P= 0.006).CONCLUSION: It is evident from the current findings that prevalence of anaemia and ID showed different trends about BMI of pregnant women.
Myialges trinotoni (Acariformes: Epidermoptidae), a hyperparasitic mite infesting Trinoton querquedulae (Phthiraptera: Menoponidae) on waterfowl
Authors: Knee Wayne , Galloway Terry D. 
Published: May 2017

AbstractMites of the family Epidermoptidae (Acariformes) are permanent parasites dwelling on or in the skin of birds. Myialges Trouessart species are epidermoptids that have a hyperparasitic relationship with chewing lice (Phthiraptera) or louse flies (Diptera: Hippoboscidae). During 1993–2016 in Manitoba, Canada, 668 ducks (20 species), geese (five species), and swans (two species) were examined for lice. A total of 157 males, 191 females, and 539 nymphs of the menoponid louse Trinoton querquedulae (Linnaeus) (Phthiraptera: Menoponidae) were collected, of which 25 adult lice from three hosts (Mergus merganser Linnaeus, Lophodytes cucullatus (Linnaeus), Anas platyrhynchos Linnaeus; Aves: Anatidae) were infested with 38 female Myialges trinotoni (Cooreman). Overall prevalence and intensity of M. trinotoni was low, and mites showed no statistically significant preference between male and female lice. Myialges trinotoni is recorded from Canada (Manitoba) and United States of America (Alaska) for the first time, and two novel avian host species records (Lophodytes cucullatus and Anas platyrhynchos) are reported. The male of M. trinotoni (loose in bird washing) is illustrated and described. The barcode region of cytochrome oxidase subunit I (COI) was amplified from M. trinoton and compared with that of Myialges caulotoon Speiser, the only congeneric species for which COI is available, and interspecific divergence was high (25%).
The Effects of Medication Alerts on Prescriber Response in a Pediatric Hospital
Authors: Dexheimer Judith , Kirkendall Eric , Kouril Michal , Hagedorn Philip , Minich Thomas , Duan Leo , Mahdi Monifa , Szczesniak Rhonda , Spooner S. Andrew 
Published: May 2017

SummaryObjective: More than 70% of hospitals in the United States have electronic health records (EHRs). Clinical decision support (CDS) presents clinicians with electronic alerts during the course of patient care; however, alert fatigue can influence a provider’s response to any EHR alert. The primary goal was to evaluate the effects of alert burden on user response to the alerts.Methods: We performed a retrospective study of medication alerts over a 24-month period (1/2013–12/2014) in a large pediatric academic medical center. The institutional review board approved this study. The primary outcome measure was alert salience, a measure of whether or not the prescriber took any corrective action on the order that generated an alert. We estimated the ideal number of alerts to maximize salience. Salience rates were examined for providers at each training level, by day of week, and time of day through logistic regressions.Results: While salience never exceeded 38%, 49 alerts/day were associated with maximal salience in our dataset. The time of day an order was placed was associated with alert salience (maximal salience 2am). The day of the week was also associated with alert salience (maximal salience on Wednesday). Provider role did not have an impact on salience.Conclusion: Alert burden plays a role in influencing provider response to medication alerts. An increased number of alerts a provider saw during a one-day period did not directly lead to decreased response to alerts. Given the multiple factors influencing the response to alerts, efforts focused solely on burden are not likely to be effective.Citation: Dexheimer JW, Kirkendall ES, Kouril M, Hagedorn PA, Minich T, Duan LL, Mahdi M, Szczesniak R, Spooner SA. The effects of medication alerts on prescriber response in a pediatric hospital. Appl Clin Inform 2017; 8: 491–501 https://doi.org/10.4338/ACI-2016-10-RA-0168
Regionalizing nonparametric models of precipitation amounts on different temporal scales
Authors: Mosthaf Tobias , Bárdossy András 
Published: May 2017

Abstract. Parametric distribution functions are commonly used to model precipitation amounts corresponding to different durations. The precipitation amounts themselves are crucial for stochastic rainfall generators and weather generators. Nonparametric kernel density estimates (KDEs) offer a more flexible way to model precipitation amounts. As already stated in their name, these models do not exhibit parameters that can be easily regionalized to run rainfall generators at ungauged locations as well as at gauged locations. To overcome this deficiency, we present a new interpolation scheme for nonparametric models and evaluate it for different temporal resolutions ranging from hourly to monthly. During the evaluation, the nonparametric methods are compared to commonly used parametric models like the two-parameter gamma and the mixed-exponential distribution. As water volume is considered to be an essential parameter for applications like flood modeling, a Lorenz-curve-based criterion is also introduced. To add value to the estimation of data at sub-daily resolutions, we incorporated the plentiful daily measurements in the interpolation scheme, and this idea was evaluated. The study region is the federal state of Baden-Württemberg in the southwest of Germany with more than 500 rain gauges. The validation results show that the newly proposed nonparametric interpolation scheme provides reasonable results and that the incorporation of daily values in the regionalization of sub-daily models is very beneficial.
Visualizing Morphogenesis with the Processing Programming Language
Authors: Patel Avik , Bains Amar , Millet Richard , Elul Tamira 
Published: May 2017

We used Processing, a visual artists’ programming language developed at MIT Media Lab, to simulate cellular mechanisms of morphogenesis – the generation of form and shape in embryonic tissues. Based on observations of in vivo time-lapse image sequences, we created animations of neural cell motility responsible for elongating the spinal cord, and of optic axon branching dynamics that establish primary visual connectivity. These visual models underscore the significance of the computational decomposition of cellular dynamics underlying morphogenesi.
Effects of Fecal Sampling on Preanalytical and Analytical Phases in Quantitative Fecal Immunochemical Tests for Hemoglobin
Authors: Rapi Stefano , Berardi Margherita , Cellai Filippo , Ciattini Samuele , Chelazzi Laura , Ognibene Agostino , Rubeca Tiziana 
Published: May 2017

Background Information on preanalytical variability is mandatory to bring laboratories up to ISO 15189 requirements. Fecal sampling is greatly affected by lack of harmonization in laboratory medicine. The aims of this study were to obtain information on the devices used for fecal sampling and to explore the effect of different amounts of feces on the results from the fecal immunochemical test for hemoglobin (FIT-Hb). Methods Four commercial sample collection devices for quantitative FIT-Hb measurements were investigated. The volume of interest (VOI) of the probes was measured from diameter and geometry. Quantitative measurements of the mass of feces were carried out by gravimetry. The effects of an increased amount of feces on the analytical environment were investigated measuring the Hb values with a single analytical method. Results VOI was 8.22, 7.1 and 9.44 mm3 for probes that collected a target of 10 mg of feces, and 3.08 mm3 for one probe that targeted 2 mg of feces. The ratio between recovered and target amounts of devices ranged from 56% to 121%. Different changes in the measured Hb values were observed, in adding increasing amounts of feces in commercial buffers. Conclusions The amounts of collected materials are related to the design of probes. Three out 4 manufacturers declare the same target amount using different sampling volumes and obtaining different amounts of collected materials. The introduction of a standard probes to reduce preanalytical variability could be an useful step for fecal test harmonization and to fulfill the ISO 15189 requirements.
Clinical, Biomechanical and Morphological Assessment of Anterior Cruciate Ligament Kevlar®-Based Artificial Prosthesis in Rabbit Model
Authors: de la Garza-Castro Santiago , González-Rivera Carlos E. , Vílchez-Cavazos Félix , Morales-Avalos Rodolfo , Barrera-Flores Francisco J. , Elizondo-Omaña Rodrigo E. , Soto-Dominguez Adolfo , Acosta-Olivo Carlos , Mendoza-Lemus Oscar F. 
Published: May 2017

Background The aim of this study was to evaluate the clinical, biomechanical and morphological characteristics of a Kevlar®-based prosthetic ligament as a synthetic graft of the anterior cruciate ligament (ACL) in an experimental animal model in rabbits. Methods A total of 27 knees of rabbits randomly divided into 3 groups (control, ACL excision and ACL replacement with a Kevlar® prosthesis) were analyzed using clinical, biomechanical and morphological tests at 6, 12 and 18 weeks postprocedure. Results The mean displacement in mechanical testing was 0.73 ± 0.06 mm, 1.58 ± 0.19 mm and 0.94 ± 0.20 mm for the control, ACL excision and ACL replacement with synthetic prosthesis groups, respectively. The results showed an improvement in the stability of the knee with the use of the Kevlar® synthetic prosthesis in the biomechanical testing (p<0.05) compared with rabbits that underwent ACL excision, in addition to displacements that were larger but comparable to that in the control group (p>0.05), between the replacement group and the control group. The histological study revealed a good morphological adaptation of the synthetic material to the knee. Conclusions This study proposes a new animal model for the placement and evaluation of Kevlar®-based synthetic ACL implants. The studied prosthesis showed promising behavior in the clinical and biomechanical tests and in the histological analysis. This study lays the foundation for further basic and clinical studies of artificial ACL prostheses using this material.
Use of a Combination of CEA and Tumor Budding to Identify High-risk Patients with Stage II Colon Cancer
Authors: Du Changzheng , Xue Weicheng , Dou Fangyuan , Peng Yifan , Yao Yunfeng , Zhao Jun , Gu Jin 
Published: May 2017

Background High-risk patients with stage II colon cancer may benefit from adjuvant chemotherapy, but identifying this patient population can be difficult. We assessed the prognosis value for predicting tumor progression in patients with stage II colon cancer, of a panel of 2 biomarkers for colon cancer: tumor budding and preoperative carcinoembryonic antigen (CEA). Methods Consecutive patients (N = 134) with stage II colon cancer who underwent curative surgery from 2000 to 2007 were included. Multivariate analysis was used to evaluate the association of CEA and tumor budding grade with 5-year disease-free survival (DFS). The prognostic accuracy of CEA, tumor budding grade and the combination of both (CEA-budding panel) was determined. Results The study found that both CEA and tumor budding grade were associated with 5-year DFS. The prognostic accuracy for disease progression was higher for the CEA-budding panel (82.1%) than either CEA (70.9%) or tumor budding grade (72.4%) alone. Conclusions The findings indicate that the combination of CEA levels and tumor budding grade has greater prognostic value for identifying patients with stage II colon cancer who are at high-risk for disease progression, than either marker alone.
Trigger Point Injections for Pelvic Floor Myofascial Spasm Refractive to Primary Therapy
Authors: Fouad Lina S. , Pettit Paul D. , Threadcraft Marcus , Wells Ali , Micallef Audrey , Chen Anita H. 
Published: May 2017

Introduction A retrospective chart review was conducted of visual analog scale (VAS) scores completed before and after trigger point injections (TPIs) for pelvic floor myofascial spasm to evaluate response. Methods Sixty-eight female patients who underwent TPIs from October 9, 2007 to March 12, 2015 were included. The primary end point was the difference between scores. Secondary analyses were conducted for patients who needed repeat TPIs. Descriptive and paired t test analyses were used. Results The key result was an improvement in VAS scores for 65% (44/68) of patients (p<0.0001). The median pre-injection VAS score was 7 (1 to 10), (mean 6.3). The median post-injection VAS score was 4 (0 to 9), (mean 4.3). The median difference between scores in patients who improved was 3 (1 to 8), (mean 3.6). Seventeen of 68 (25%) patients needed repeat TPI, and the median time between injections was 1.5 months (1 to 7 months), (mean 2.2 months). When analyzing pre-injection VAS scores in patients who underwent subsequent repeat injection when compared to patients who did not require repeat injection, there was no difference (p = 0.32). In addition, the differences between pre- and post-injection VAS scores in the patients who underwent repeat injection and those who did not was not significant (p = 0.26). Conclusions We report on 68 women who underwent TPIs, with an improvement in VAS pain scores in 65%. It appears that TPIs for pelvic floor myofascial spasm are successful in reducing pain scores for patients who are refractory to primary therapy.
Initiation of antiplatelet medication after surgical thrombectomy jeopardized arteriovenous graft longevity
Authors: Yeh Chi-Hsiao , Huang Ting-Shuo , Wang Yao-Chang , Huang Pin-Fu , Huang Tzu-Yen , Chen Tzu-Ping , Yin Shun-Ying 
Published: May 2017

Introduction The efficacy of antiplatelet agents in preventing thrombosis in newly formed arteriovenous graft (AVG) in hemodialysis (HD) patients has been extensively examined. The aim of this study was to investigate the possible effect of initiation of antiplatelet medications on preventing AVG thrombosis recurrence after surgical thrombectomy for acute occlusion in HD patients. Whether post-operatively antiplatelet medications have protective effects on the patency or longevity of AVG after surgical thrombectomy in HD patients has not been investigated. Methods We conducted a 4-year quasi-randomized study of the unassisted patency and AVG longevity for 213 HD patients with or without initiating antiplatelet drugs after receiving surgical thrombectomy for first episode of acute AVG thrombosis. Results From the propensity-score-matched quasi-randomized study, initiation of antiplatelet drugs after first surgical thrombectomy in HD patients did not prevent the recurrence of surgical thrombectomy (log-rank p = 0.81), but significantly decreased the longevity of the access (log-rank p = 0.034). Multivariate Cox model demonstrated that prescription of antiplatelet drugs significantly increased the risk of graft failure (adjusted hazard ratio 2.13, p = 0.025). Conclusions Adjunctive prescription with antiplatelet medications in HD patients after surgical thrombectomy did not prevent recurrent thrombosis of AV access, but significantly jeopardized the longevity of AVG after surgical thrombectomy.
Primary and secondary patencies of transposed femoral vein fistulas are significantly greater than with the HeRO graft
Authors: Ladenheim Eric D. , Lulic Dzenan , Lum Craig , Agrawal Sid 
Published: May 2017

Introduction For access-challenged patients with bilateral upper extremity central venous stenosis, solutions include the Hemodialysis Reliable Outflow (HeRO) device or an autogenous AV fistula in the lower limb. We evaluated HeRO grafts and transpositions of the femoral vein in maintaining primary and secondary patency. Methods We retrospectively analyzed 40 patients with a HeRO device and 18 patients with superficial femoral artery to transposed femoral vein autogenous arteriovenous fistula (SFA-tFV). All patients had bilateral central venous obstruction. All procedures were outpatient performed by a single surgeon at one center between 2009-2015. Operative details, intraoperative flows, and flows at the first-week postoperative visit were analyzed, as were primary and secondary patency and intervention rates. Complications were compared between groups. Results The one-year cumulative primary patency was 30% for HeRO grafts and 79% for SFA-tFV fistulas (p = 0.0001); secondary patency was 71% for HeRO grafts and 93% for SFA-tFV fistulas (p = 0.03). To maintain patency, HeRO patients required a mean 2.1 interventions per year and thigh fistula patients required a mean 0.4 interventions per year. Thirty-seven percent of thigh fistula patients had a hematoma or seroma versus 5% of HeRO patients and 17% of thigh fistula patients experienced delayed wound healing versus 2.5% of HeRO patients (p<0.05). None of the thigh fistula patients had distal ischemia. Conclusions HeRO patients had lower primary and secondary patency rates versus thigh fistula patients and HeRO grafts required five-fold more interventions to maintain secondary patency. However, patients with thigh fistulas had significantly more wound healing problems. Thus, the SFA-tFV has become our access of choice for patients with bilateral central venous stenosis.