bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiferromagnetic structure in tetragonal CuMnAs thin films
Authors: Wadley P. , Hills V. , Shahedkhah M. R. , Edmonds K. W. , Campion R. P. , Novák V. , Ouladdiaf B. , Khalyavin D. , Langridge S. , Saidl V. , Nemec P. , Rushforth A. W. , Gallagher B. L. , Dhesi S. S. , Maccherozzi F. , Železný J. , Jungwirth T. 
Published: November 2015

AbstractTetragonal CuMnAs is an antiferromagnetic material with favourable properties for applications in spintronics. Using a combination of neutron diffraction and x-ray magnetic linear dichroism, we determine the spin axis and magnetic structure in tetragonal CuMnAs and reveal the presence of an interfacial uniaxial magnetic anisotropy. From the temperature-dependence of the neutron diffraction intensities, the Néel temperature is shown to be (480 ± 5) K. Ab initio calculations indicate a weak anisotropy in the (ab) plane for bulk crystals, with a large anisotropy energy barrier between in-plane and perpendicular-to-plane directions.
Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup
Authors: Beck Emily A. , Llopart Ana 
Published: November 2015

AbstractRapid evolution of centromeric satellite repeats is thought to cause compensatory amino acid evolution in interacting centromere-associated kinetochore proteins. Cid, a protein that mediates kinetochore/centromere interactions, displays particularly high amino acid turnover. Rapid evolution of both Cid and centromeric satellite repeats led us to hypothesize that the apparent compensatory evolution may extend to interacting partners in the Condensin I complex (i.e., SMC2, SMC4, Cap-H, Cap-D2 and Cap-G) and HP1s. Missense mutations in these proteins often result in improper centromere formation and aberrant chromosome segregation, thus selection for maintained function and coevolution among proteins of the complex is likely strong. Here, we report evidence of rapid evolution and recurrent positive selection in seven centromere-associated proteins in species of the Drosophila melanogaster subgroup and further postulate that positive selection on these proteins could be a result of centromere drive and compensatory changes, with kinetochore proteins competing for optimal spindle attachment.
Bottom pressure scaling of vibro-fluidized granular matter
Authors: Katsuragi Hiroaki 
Published: November 2015

AbstractVibrated granular beds show various interesting phenomena such as convection, segregation and so on. However, its fundamental physical properties (e.g., internal pressure structure) have not yet been understood well. Thus, in this study, the bottom wall pressure in a vertically vibrated granular column is experimentally measured and used to reveal the nature of granular fluidization. The scaling method allows us to elucidate the fluidization (softening) degree of a vibrated granular column. The peak value of the bottom pressure pm is scaled as "Equation missing"Γ, where pJ, d, g, ω, H and Γ are the Janssen pressure, grain diameter, gravitational acceleration, angular frequency, height of the column and dimensionless vibrational acceleration, respectively. This scaling implies that the pressure of vibrated granular matter is quite different from the classical pressure forms: static and dynamic pressures. This scaling represents the importance of geometric factors for discussing the behavior of vibro-fluidized granular matter. The scaling is also useful to evaluate the dissipation degree in vibro-fluidized granular matter.
Integrated network model provides new insights into castration-resistant prostate cancer
Authors: Hu Yanling , Gu Yinmin , Wang Huimin , Huang Yuanjie , Zou Yi Ming 
Published: November 2015

AbstractCastration-resistant prostate cancer (CRPC) is the main challenge for prostate cancer treatment. Recent studies have indicated that extending the treatments to simultaneously targeting different pathways could provide better approaches. To better understand the regulatory functions of different pathways, a system-wide study of CRPC regulation is necessary. For this purpose, we constructed a comprehensive CRPC regulatory network by integrating multiple pathways such as the MEK/ERK and the PI3K/AKT pathways. We studied the feedback loops of this network and found that AKT was involved in all detected negative feedback loops. We translated the network into a predictive Boolean model and analyzed the stable states and the control effects of genes using novel methods. We found that the stable states naturally divide into two obvious groups characterizing PC3 and DU145 cells respectively. Stable state analysis further revealed that several critical genes, such as PTEN, AKT, RAF and CDKN2A, had distinct expression behaviors in different clusters. Our model predicted the control effects of many genes. We used several public datasets as well as FHL2 overexpression to verify our finding. The results of this study can help in identifying potential therapeutic targets, especially simultaneous targets of multiple pathways, for CRPC.
Best‐practice pain management in the emergency department: A cluster‐randomised, controlled, intervention trial
Authors: Taylor David McD , Fatovich Daniel M , Finucci Daniel P , Furyk Jeremy , Jin Sang‐won , Keijzers Gerben , Macdonald Stephen PJ , Mitenko Hugh MA , Richardson Joanna R , Ting Joseph YS , Thom Ogilvie N , Ugoni Antony M , Hughes James A , Bost Nerolie , Ward Meagan L , Gibbs Clinton R , Macdonald Ellen , Chalkley Dane R 
Published: November 2015

AbstractObjectivesWe aimed to provide ‘adequate analgesia’ (which decreases the pain score by ≥2 and to <4 [0–10 scale]) and determine the effect on patient satisfaction.MethodsWe undertook a multicentre, cluster‐randomised, controlled, intervention trial in nine EDs. Patients with moderate pain (pain score of ≥4) were eligible for inclusion. The intervention was a range of educational activities to encourage staff to provide ‘adequate analgesia’. It was introduced into five early intervention EDs between the 0 and 6 months time points and at four late intervention EDs between 3 and 6 months. At 0, 3 and 6 months, data were collected on demographics, pain scores, analgesia provided and pain management satisfaction 48 h post‐discharge (6 point scale).ResultsOverall, 1317 patients were enrolled. Logistic regression (controlling for site and other confounders) indicated that, between 0 and 3 months, satisfaction increased significantly at the early intervention EDs (OR 2.2, 95% CI 1.5 to 3.4 [P < 0.01]) but was stable at the control EDs (OR 0.8, 95% CI 0.5 to 1.3 [P = 0.35]). Pooling of data from all sites indicated that the proportion of patients very satisfied with their pain management increased from 42.9% immediately pre‐intervention to 53.9% after 3 months of intervention (difference in proportions 11.0%, 95% CI 4.2 to 17.8 [P = 0.001]). Logistic regression of all data indicated that ‘adequate analgesia’ was significantly associated with patient satisfaction (OR 1.4, 95% CI 1.1 to 1.8 [P < 0.01]).ConclusionsThe ‘adequate analgesia’ intervention significantly improved patient satisfaction. It provides a simple and efficient target in the pursuit of best‐practice ED pain management.
Does income inequality increase charitable giving?
Authors: Payne A. Abigail , Smith Justin 
Published: November 2015

AbstractDo households react to changes in the distribution of income in their localities by changing their charitable giving? The theoretical prediction of the effects of income inequality on giving is unclear. We study how changes in income inequality measured at the neighbourhood and municipality levels affect charitable giving by households in Canada between 1991 and 2006. We find that increases in inequality increase giving. Results are sensitive to the geographic dispersion of low‐ and high‐income households in neighbourhoods within a municipality. The effect on donations is smaller in areas with high levels of inequality at both neighbourhood and municipality levels.
Long‐term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt?
Authors: Selvey L. A. , Speers D. J. , Smith D. W. 
Published: November 2015

BackgroundMurray Valley encephalitis virus (MVEV) is a mosquito‐borne flavivirus that causes encephalitis in some cases of infection. It is endemic in Northern Australia and cases occasionally occur in South Eastern Australia. The long‐term sequelae of MVEV infection have not previously been well described.AimTo investigate the long‐term sequelae of MVEV infection.MethodsThis was a descriptive case series of all clinical MVEV infections using data linkage and standard surveys. Hospital admissions, emergency department, psychiatric outpatients and mortality data were obtained. We attempted to follow‐up all 53 cases of MVEV clinical infection that occurred in Western Australia from 1978 to 2011 inclusive. Two cases opted out of the study.ResultsWe followed‐up 39 surviving cases. Seven of the nine with paralysis or paresis were under 5 years and they fared worse than other patients, requiring lengthy hospitalisation (median duration 133 days). Two died due to complications of quadriplegia following a total of 691 days in hospital. Nine surviving patients, including two with non‐encephalitic illness, required care for depression and other psychiatric conditions following MVEV infection. Two patients who were discharged with neurological sequelae had no further documented hospital occasions of service but reported ongoing challenges with cognitive dysfunction and inability to work.ConclusionsThis is the first study of long‐term outcomes of Murray Valley encephalitis that included cases with no obvious sequelae at discharge. In spite of the small numbers involved, the study demonstrated the significant medical and social burden due to MVEV in Australia.
Refining prognosis after trans‐arterial chemo‐embolization for hepatocellular carcinoma
Authors: Cappelli Alberta , Cucchetti Alessandro , Cabibbo Giuseppe , Mosconi Cristina , Maida Marcello , Attardo Simona , Pettinari Irene , Pinna Antonio D. , Golfieri Rita 
Published: November 2015

AbstractBackground & AimsTo develop an individual prognostic calculator for patients with unresectable hepatocellular carcinoma (HCC) undergoing trans‐arterial chemo‐embolization (TACE).MethodsData from two prospective databases, regarding 361 patients who received TACE as first‐line therapy (2000–2012), were reviewed in order to refine available prognostic tools and to develop a continuous individual web‐based prognostic calculator. Patients with neoplastic portal vein invasion were excluded from the analysis. The model was built following a bootstrap resampling procedure aimed at identifying prognostic predictors and by carrying out a 10‐fold cross‐validation for accuracy assessment by means of Harrell's c‐statistic.ResultsNumber of tumours, serum albumin, serum total bilirubin, alpha‐foetoprotein and maximum tumour size were selected as predictors of mortality following TACE with the bootstrap resampling technique. In the 10‐fold cross‐validation cohort, the model showed a Harrell's c‐statistic of 0.649 (95% CI: 0.610–0.688), significantly higher than that of the Hepatoma Arterial‐embolization Prognostic (HAP) score (0.589; 95% CI: 0.552–0.626; P = 0.001) and of the modified HAP‐II score (0.611; 95% CI: 0.572–0.650; P = 0.005). Akaike's information criterion for the model was 2520; for the mHAP‐II it was 2544 and for the HAP score it was 2554. A web‐based calculator was developed for quick consultation at http://www.livercancer.eu/mhap3.html.ConclusionsThe proposed individual prognostic model can provide an accurate prognostic prediction for each patient with unresectable HCC following treatment with TACE without class stratification. The availability of an online calculator can help physicians in daily clinical practice.
Human lactoferrin protects against Streptococcus mutans‐induced caries in mice
Authors: Velusamy SK , Markowitz K , Fine DH , Velliyagounder K 
Published: November 2015

ObjectivesThe objective of this study is to evaluate the importance of human lactoferrin (hLF) in an experimental caries induced by Streptococcus mutans in a lactoferrin‐knockout (LFKO−/−) mouse model compared with C576J/BL wild‐type (WT) mice.Materials and MethodsThe WT and LFKO−/− mice were infected with S. mutans (1 × 108 cells) and/or sham infection. Furthermore, the effect of hLF administration was evaluated in LFKO−/− mice infected with S. mutans. Mice were assessed for colonization, salivary pH, and caries development.ResultsThe results showed that the lactoferrin‐knockout infected (LFKO−/−I) mice had significantly higher colonization with S. mutans (P = 0.02), lower salivary pH (P = 0.01), and more carious lesions (P = 0.01) when compared to wild‐type infected (WTI) mice. In addition, the administration of hLF did not show any evidence of S. mutans colonization as well as carious lesions (P = 0.001) in LFKO−/−I mice when compared to untreated LFKO−/−I mice.ConclusionThese results show that endogenous LF protects against S. mutans‐induced caries and that exogenous hLF can exert a protective effect against caries development.
ACOUSTICAL STANDARDS NEWS
Authors: Blaeser Susan B. , Struck Christopher J. 
Published: November 2015

American National Standards (ANSI Standards) developed by Accredited Standards Committees S1, S2, S3, S3/SC 1, and S12 in the areas of acoustics, mechanical vibration and shock, bioacoustics, animal bioacoustics, and noise, respectively, are published by the Acoustical Society of America (ASA). In addition to these standards, ASA publishes a catalog of Acoustical American National Standards. To receive a copy of the latest Standards catalog, please contact Susan B. Blaeser.
Comments are welcomed on all material in Acoustical Standards News.
This Acoustical Standards News section in JASA, as well as the National Catalog of Acoustical Standards and other information on the Standards Program of the Acoustical Society of America, are available via the ASA home page: http://acousticalsociety.org.
Student Perceptions of Instructional Choices in Middle School Physical Education
Authors: Agbuga Bulent , Xiang Ping , McBride Ron E. , Su Xiaoxia 
Published: November 2015

Purpose:Framed within self-determination theory, this study examined relationships among perceived instructional choices (cognitive, organizational, and procedural), autonomy need satisfaction, and engagement (behavioral, cognitive, and emotional) among Turkish students in middle school physical education.Methods:Participants consisted of 246 (124 boys, 122 girls) middle school students enrolled in physical education classes at four public schools in the west Turkey. Questionnaires were used to collect the data.Results:Perceived cognitive, organizational and procedural choices were found all important to students’ autonomy need satisfaction and/or engagement. Autonomy need satisfaction fully or partially mediated the relationships between perceived instructional choices and engagement.Discussion/Conclusion:The study provides empirical data that instructional choices supported student autonomy need satisfaction, and were related to student engagement in middle school physical education.
Circulating DNA and Survival in Solid Tumors
Authors: Ocaña Alberto , Díez-González Laura , García-Olmo Dolores C. , Templeton Arnoud J. , Vera-Badillo Francisco , José Escribano María , Serrano-Heras Gemma , Corrales-Sánchez Verónica , Seruga Bostjan , Andrés-Pretel Fernando , Pandiella Atanasio , Amir Eitan 
Published: November 2015

Abstract
Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict clinical outcomes.
Methods: A systematic review of electronic databases identified publications exploring the association between cfDNA or ctDNA and overall survival (OS) in solid tumors. HRs for OS were extracted from multivariable analyses and included in a meta-analysis. Pooled HRs were computed and weighted using generic inverse variance and random-effect modeling. For studies not reporting multivariable analyses, univariable ORs were estimated from Kaplan–Meier curves for OS at 1 and 3 years.
Results: Thirty-nine studies comprising 4,052 patients were included in the analysis. Detection of ctDNA was associated with a significantly worse OS in multivariable analyses [HR, 2.70; 95% confidence interval (CI), 2.02–3.61; P &lt; 0.001). Similar results were observed in the univariable analyses at 3 and 1 year (OR, 4.83; 95% CI, 3.20–7.28; P &lt; 0.001).There was also a statistically significant association between high total cfDNA and worse OS for studies reporting multivariable and univariate data at 3 years (HR, 1.91; 95% CI, 1.59–2.29; P &lt; 0.001 and OR, 2.82; 95% CI, 1.93–4.13; P &lt; 0.001, respectively).
Conclusions: High levels of total cfDNA and presence of ctDNA are associated with worse survival in solid tumors.
Impact: Circulating DNA is associated with worse outcome in solid tumors. Cancer Epidemiol Biomarkers Prev; 25(2); 399–406. ©2015 AACR.
The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma
Authors: Martínez-Vélez Naiara , Xipell Enric , Vera Beatriz , Acanda de la Rocha Arlet , Zalacain Marta , Marrodán Lucía , Gonzalez-Huarriz Marisol , Toledo Gemma , Cascallo Manel , Alemany Ramón , Patiño Ana , Alonso Marta M. 
Published: November 2015

Abstract
Purpose: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Despite aggressive chemotherapy, more than 30% of patients do not respond and develop bone or lung metastasis. Oncolytic adenoviruses engineered to specifically destroy cancer cells are a feasible option for osteosarcoma treatment. VCN-01 is a replication-competent adenovirus specifically engineered to replicate in tumors with a defective RB pathway, presents an enhanced infectivity through a modified fiber and an improved distribution through the expression of a soluble hyaluronidase. The aim of this study is to elucidate whether the use of VCN-01 would be an effective therapeutic strategy for pediatric osteosarcoma.
Experimental Design: We used osteosarcoma cell lines established from patients with metastatic disease (531MII, 678R, 588M, and 595M) and a commercial cell line (143B). MTT assays were carried out to evaluate the cytotoxicity of VCN-01. Hexon assays were used to evaluate the replication of the virus. Western blot analysis was performed to assess the expression levels of viral proteins and autophagic markers. The antitumor effect of VCN-01 was evaluated in orthotopic and metastatic osteosarcoma murine animal models.
Results: This study found that VCN-01, a new generation genetically modified oncolytic adenovirus, administered locally or systemically, had a potent antisarcoma effect in vitro and in vivo in mouse models of intratibial and lung metastatic osteosarcoma. Moreover, VCN-01 administration showed a safe toxicity profile.
Conclusions: These results uncover VCN-01 as a promising strategy for osteosarcoma, setting the bases to propel a phase I/II trial for kids with this disease. Clin Cancer Res; 22(9); 2217–25. ©2015 AACR.
Targeting p300 Addiction inCBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation ofMYCExpression
Authors: Ogiwara Hideaki , Sasaki Mariko , Mitachi Takafumi , Oike Takahiro , Higuchi Saito , Tominaga Yuichi , Kohno Takashi 
Published: November 2015

AbstractLoss-of-function mutations in the CBP/CREBBP gene, which encodes a histone acetyltransferase (HAT), are present in a variety of human tumors, including lung, bladder, gastric, and hematopoietic cancers. Consequently, development of a molecular targeting method capable of specifically killing CBP-deficient cancer cells would greatly improve cancer therapy. Functional screening of synthetic-lethal genes in CBP-deficient cancers identified the CBP paralog p300/EP300. Ablation of p300 in CBP-knockout and CBP-deficient cancer cells induced G1–S cell-cycle arrest, followed by apoptosis. Genome-wide gene expression analysis revealed that MYC is a major factor responsible for the synthetic lethality. Indeed, p300 ablation in CBP-deficient cells caused downregulation of MYC expression via reduction of histone acetylation in its promoter, and this lethality was rescued by exogenous MYC expression. The p300-HAT inhibitor C646 specifically suppressed the growth of CBP-deficient lung and hematopoietic cancer cells in vitro and in vivo; thus p300 is a promising therapeutic target for treatment of CBP-deficient cancers.Significance: Targeting synthetic-lethal partners of genes mutated in cancer holds great promise for treating patients without activating driver gene alterations. Here, we propose a “synthetic lethal–based therapeutic strategy” for CBP-deficient cancers by inhibition of the p300 HAT activity. Patients with CBP-deficient cancers could benefit from therapy using p300-HAT inhibitors. Cancer Discov; 6(4); 430–45. ©2015 AACR.See related commentary by Kadoch, p. 350.This article is highlighted in the In This Issue feature, p. 331
Entre o desejo e a impossibilidade: o sujeito e a(s) língua(s)
Authors: Murakami Mariane Harumi 
Published: November 2015

Resenha de CORACINI, Maria José. A celebração do outro: arquivo, memória e identidade. Línguas (materna e estrangeira), plurilingüismo e tradução. Campinas, SP: Mercado das Letras, 2007.
Quatro ambivalências na Teoria da Comunicação
Authors: Martino Luis Mauro Sa 
Published: November 2015

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