bluuebunny/crossref_metadata_2025_split huggingface dataset:
In VivoDelivery of Nanoparticles into Plant Leaves
Authors: Wu Honghong , Santana Israel , Dansie Joshua , Giraldo Juan P. 
Published: December 2017

AbstractPlant nanobiotechnology is an interdisciplinary field at the interface of nanotechnology and plant biology that aims to utilize nanomaterials as tools to study, augment or impart novel plant functions. The delivery of nanoparticles to plantsin vivois a key initial step to investigate plant nanoparticle interactions and the impact of nanoparticles on plant function. Quantum dots are smaller than plant cell wall pores, have versatile surface chemistry, bright fluorescence and do not photobleach, making them ideal for the study of nanoparticle uptake, transport, and distribution in plants by widely available confocal microscopy tools. Herein, we describe three different methods for quantum dot delivery into leaves of living plants: leaf lamina infiltration, whole shoot vacuum infiltration, and root to leaf translocation. These methods can be potentially extended to other nanoparticles, including nanosensors and drug delivery nanoparticles. © 2017 by John Wiley & Sons, Inc.
(Re-) Meshing using interpolative mapping and control point optimization
Authors: Voutchkov Ivan , Keane Andy , Shahpar Shahrokh , Bates Ron 
Published: December 2017

Abstract
This work proposes a simple and fast approach for re-meshing the surfaces of smooth-featured geometries prior to CFD analysis. The aim is to improve mesh quality and thus the convergence and accuracy of the CFD analysis. The method is based on constructing an interpolant based on the geometry shape and then mapping a regular rectangular grid to the shape of the original geometry using that interpolant. Depending on the selected interpolation algorithm the process takes from less than a second to several minutes. The main interpolant discussed in this article is a Radial Basis Function with cubic spline basis, however other algorithms are also compared. The mesh can be optimized further using active (flexible) control points and optimization algorithms. A range of objective functions are discussed and demonstrated. The difference between re-interpolated and original meshes produces a metric function which is indicative of the mesh quality. It is shown that the method works for flat 2D surfaces, 3D surfaces and volumes.
Highlights RBF Map is created between key points on an arbitrary shape and an ideal equivalent. The rest of the points are recreated using reverse transformation to the original. Control points are automatically selected based on k-mean clustering. Optimization of the control points position based on desired mesh quality metrics. The method is shown to work both on 2D and 3D shapes as well as 3D surfaces.
S&P 500 Index revisions and credit spreads
Authors: Baran Lindsay , Li Ying , Liu Chang , Liu Zilong , Pu Xiaoling 
Published: December 2017

AbstractWe investigate the impact of S&P 500 Index revisions on credit spreads from 2001 to 2014. Additions have a significant negative impact on credit default swap (CDS) spreads both during the financial crisis period and for speculative grade firms, but deletions show no significant CDS spread changes. After excluding the effect of market integration between the stock and CDS markets, we find that S&P 500 Index inclusion conveys no unique information beyond that due to market integration except during the financial crisis. Furthermore, CDS trading liquidity does not improve after S&P 500 Index inclusion.
Nocturnal bird diversity in forest fragments in north-west Ecuador
Authors: Walter Scott T. , Browne Luke , Freile Juan , González Nelson , Loor Julio , Darkes Michael , Gillespie Thomas W. , Karubian Jordan 
Published: December 2017

Abstract:Habitat preferences and response to habitat conversion remain under-studied for many groups in the tropics, limiting our understanding of how environmental and anthropogenic factors may interact to shape patterns of diversity. To help fill this knowledge gap, we surveyed nocturnal birds such as owls, nightjars and potoos through auditory transect surveys in 22 forest fragments (2.7 to 33.6 ha) in north-west Ecuador. We assessed the relative effect of habitat characteristics (e.g. canopy height and openness, and density of large trees) and fragment attributes (e.g. area, altitude and proportion of surrounding forest cover) on species richness and community composition. Based on our previous work, we predicted that nocturnal bird richness would be highest in relatively larger fragments with more surrounding forest cover. We recorded 11 total species with an average ± SD of 3.4 ± 1.4 (range = 2–7) species per fragment, with higher richness in fragments that were larger, at lower altitudes, and characterized by more open canopies. Nocturnal bird community similarity was not significantly correlated with any measured environmental variable. These results indicate that both landscape (e.g. altitude) and fragment-specific (e.g. size, forest structure) attributes are likely to interact to shape patterns of diversity among this poorly known but ecologically important guild in fragmented tropical landscapes.
Oleic acid in the modulation of oocyte and preimplantation embryo development
Authors: Fayezi Shabnam , Leroy Jo L.M.R. , Ghaffari Novin Marefat , Darabi Masoud 
Published: December 2017

SummaryPotential reproductive effects are considered as the major aspect of biomolecules functionality in an organism. The recent identification of differential patterns of fatty acids across ovarian follicles and their association with levels of sexual maturity highlights the importance of these biomolecules. It is well known that fatty acids are highly diverse in terms of their functional properties. Oleic acid is chemically classified as an unsaturated omega-9 fatty acid. Besides serving as an important energy source, oleic acid is involved in metabolic and structural roles. Free and esterified oleic acids are compartmentalized into discrete extracellular fluids, cell organelles and found within the cytosol. This review summarizes the current knowledge on the contribution of oleic acid in regulating female fertility, particularly its involvement in female germ cell growth and development. Oleic acid has been identified as a blastomeric and post-cryopreservation survival biomarker in bovine. Several related studies have shown the critical role of oleic acid in counteracting the detrimental effects of saturated fatty acids and in paracrine support of oocyte development. Although available data are not ideally detailed, most data suggest that oleic acid can contribute to normal oocyte and preimplantation embryo development via mechanisms involving metabolic partitioning of fatty acids, change in the membrane structural organization, attenuation of oxidative stress and regulation of intracellular signalling. Thus, oleic acid may play a significant role in oocyte and early embryo development, suggesting that future studies should explore in more detail its potential effects on the physiopathology of female reproduction.
Assessing Procrastination
Authors: Klein Eva M. , Beutel Manfred E. , Müller Kai W. , Wölfling Klaus , Brähler Elmar , Zenger Markus 
Published: December 2017

Abstract. The short form of the General Procrastination Scale (GPS-K; Klingsieck & Fries, 2012 ; Lay, 1986 ) is a reliable self-report scale measuring general procrastination. The presumed one-dimensional factor structure of the scale, however, has never been examined. Thus, the purposes of this representative study were to examine its dimensionality and factorial invariance across age and sex, and to provide norm values of the German general population. The GPS-K was administered to a representative community sample ( N = 2,527; age range 14–95 years). A confirmatory factor analysis (CFA) was conducted. To explore convergent validity, standardized scales of distress and life satisfaction were used. Measurement invariance across sex and age was tested. The CFA revealed an unsatisfactory model fit of the presumed unidimensional factor structure of the GPS-K. Therefore, a 5-item one-dimensional version of the scale was suggested (General Procrastination Scale – Screening; GPS-S). Correlations between GPS-S, distress and reduced life satisfaction provide evidence on its convergent validity. The one-dimensional GPS-S can be assumed to be scalar invariant across sex and for participants older than 29 years. The scale can be administered in only a few minutes providing an economic screening for research and practice.
Clustered repetitive transcranial magnetic stimulation for the prevention of depressive relapse/recurrence: a randomized controlled trial
Authors: Wang Hua-Ning , Wang Xiao-Xia , Zhang Rui-Guo , Wang Ying , Cai Min , Zhang Ya-Hong , Sun Run-Zhu , Guo Li , Qiao Yu-Ting , Liu Jun-Chang , He Hong , Wang Zhong-Heng , Wan Yu-Chen , Tan Qing-Rong , Zhang Zhang-Jin 
Published: December 2017

AbstractRepetitive transcranial magnetic stimulation (rTMS) may have the potential to prevent depressive relapse. This assessor-blinded, randomized controlled study was designed to evaluate the efficacy and safety of rTMS as a mono- and combination therapy in the prevention of depressive relapse/recurrence. A total of 281 depressed patients who had achieved stable full or partial remission on a 6-month antidepressant (ADP) run-in treatment were randomly assigned to an rTMS (n = 91), ADP (n = 108), or combined (rTMS + ADP, n = 82) treatment group for 12 months. Monthly clustered rTMS was conducted in 5–10 sessions over a 3–5-day period. Maintenance outcomes were assessed using time to relapse/recurrence and relapse/recurrence rate. Overall, 71.2% (200/281) of the participants completed the treatment per the protocol. rTMS + ADP and rTMS significantly reduced the risk of relapse/recurrence compared with ADP (P = 0.000), with hazard ratios of 0.297 and 0.466, respectively. Both rTMS-containing regimens produced significantly lower relapse/recurrence rates than ADP (15.9% and 24.2% vs. 44.4%, P < 0.001). In the relapsed/recurrent subgroup, first-episode depressed, rTMS-treated patients had a markedly lower relapse/recurrence rate than ADP-treated patients. Five patients on the ADP-containing regimens, but none on rTMS alone, developed acute mania. The rTMS-containing regimens had considerably more certain side effects than did the ADP group. We concluded that TMS, whether as a mono- or additional therapy, is superior to antidepressants in preventing depressive relapse/recurrence, particularly in first-episode depressed patients. The treatment does not increase the risk of manic switch, but may increase the risk of certain side effects.
Diffusion MRI measurements in challenging head and brain regions via cross-term spatiotemporally encoding
Authors: Solomon Eddy , Liberman Gilad , Zhang Zhiyong , Frydman Lucio 
Published: December 2017

AbstractCross-term spatiotemporal encoding (xSPEN) is a recently introduced imaging approach delivering single-scan 2D NMR images with unprecedented resilience to field inhomogeneities. The method relies on performing a pre-acquisition encoding and a subsequent image read out while using the disturbing frequency inhomogeneities as part of the image formation processes, rather than as artifacts to be overwhelmed by the application of external gradients. This study introduces the use of this new single-shot MRI technique as a diffusion-monitoring tool, for accessing regions that have hitherto been unapproachable by diffusion-weighted imaging (DWI) methods. In order to achieve this, xSPEN MRI’s intrinsic diffusion weighting effects are formulated using a customized, spatially-localized b-matrix analysis; with this, we devise a novel diffusion-weighting scheme that both exploits and overcomes xSPEN’s strong intrinsic weighting effects. The ability to provide reliable and robust diffusion maps in challenging head and brain regions, including the eyes and the optic nerves, is thus demonstrated in humans at 3T. New avenues for imaging other body regions are also briefly discussed.
Prognostic and predictive role of spatially positioned tumour infiltrating lymphocytes in metastatic HER2 positive breast cancer treated with trastuzumab
Authors: Honkanen Tiia J. , Moilanen Tiina , Karihtala Peeter , Tiainen Satu , Auvinen Päivi , Väyrynen Juha P. , Mäkinen Markus , Koivunen Jussi P. 
Published: December 2017

AbstractDisease outcomes of HER2+ breast cancers have dramatically changed after targeted therapies, such as trastuzumab, came to clinical practice but predictive factors for trastuzumab sensitivity and resistance are frequently unknown. Current work included metastatic breast cancer patients (n = 48), who were treated with trastuzumab and had pre-treatment tumour samples available. The tumours were immunostained for T-cell (CD3, CD8), natural killer (NK)-cell (CD56) and macrophage (CD68) markers and quantitative analysis of the immune cells was carried out using a computer-assisted image analysis in different tumour locations. High number of CD3 and CD8 positive T-cells was associated with significant survival benefit in the center of the tumour (CT) (p = 0.007, p = 0.001) but not in the invasive margin. The number of NK-cells and macrophages in the CT showed non-significant tendency towards improved survival. In subgroup analyses, high density of CD8 CT cells was associated with significant survival benefit in non-bone only disease, in TX or T1-3, and in ER+ tumours (p = 0.006, p = 0.003, p = 0.001). Moreover, high CD8 CT cell density associated significantly with long trastuzumab interruption periods in response. The results suggest important prognostic and predictive role of tumour infiltrating lymphocytes in center of the tumours in metastatic HER2+ breast cancer.
Age-Related Eye Disease and Participation in Cognitive Activities
Authors: Varin Melanie , Kergoat Marie-Jeanne , Belleville Sylvie , Li Gisele , Rousseau Jacqueline , Roy-Gagnon Marie-Hélène , Moghadaszadeh Solmaz , Freeman Ellen E. 
Published: December 2017

AbstractStudies have found a benefit to living a cognitively active life in older age. Our goal was to quantify participation in cognitively stimulating activities in adults with and without age-related eye disease. We conducted a cross-sectional hospital-based study in Montreal, Canada of older adults (n = 303) having either age-related macular degeneration (AMD) (n = 96), glaucoma (n = 93), or normal vision (n = 114). To be eligible, the AMD group had to have bilateral late stage AMD with a better eye visual acuity of 20/30 or worse. The glaucoma group had to have a diagnosis of bilateral primary open-angle glaucoma with visual field mean deviation <  = −4 dB in their better eye. Further inclusion criteria included age ≥ 65 and a Mini-Mental State Exam Blind score ≥ 10. Cognitive activities were measured using the Victoria Longitudinal Study Activity Questionnaire. Linear regression was used. Patients with AMD (β = −4.2, 95% confidence interval (CI) −6.0, −2.4) and glaucoma (β = −1.8, 95% CI −3.3, −0.3) participated in fewer cognitive activities per month compared to those with normal vision after adjusting for age, sex, education, diabetes, number of comorbidities, cognition, and cataract. People with AMD and glaucoma participated in fewer cognitive activities, which could put them at risk for future cognitive impairment.
Analysis on the peak load adjustment adaptability of the existing 300 MW cogeneration unit manufactured by STC
Authors: Yang Haisheng , Lu Shengyang , Wang Wenying 
Published: December 2017

With the increasing pressure of the strengthening the peak load adjustment capability for the cogeneration units, it is absolutely necessary that the adaptability of peak load adjustment for the existing cogeneration units be precisely studied. Model‐based software is utilised for the simulation of the 300 MW subcritical cogeneration unit manufactured by Shanghai Turbine Corporation, and detailed explanation is provided for the specific details during the modelling process. The peak load adjustment capability under various heating loads is calculated and analysed for the given unit. It is shown that with the increasing of the heating load, the span of the peak load adjustment range is gradually contracted, and the minimum power operation load is increased. The peak load adjustment capability of the existing cogeneration unit can meet the minimum load requirement of the state regulation plan for the fossil fired generation unit under 75% or lower heating load conditions. Therefore, the flexibility upgrading of the cogeneration unit should be focused on the peak load adjustment capability under large heating load conditions.
Effect of Blood Group on Ultrahigh Frequency Auditory Sensitivity
Authors: Prabhu Prashanth , Chandrashekhar Akhila , Cariappa Janani , Ghosh Nayanika 
Published: December 2017

Introduction Individuals with blood group O are reported to have reduced otoacoustic emissions (OAEs) compared with individuals with different blood groups.
Objective The present study attempted to determine if the blood group has any effect on high-frequency auditory sensitivity using ultrahigh-frequency audiometry and ultrahigh-frequency distortion product otoacoustic emissions (DPOAEs).
Methods High-frequency thresholds and high-frequency DPOAEs were measured in 60 individuals with normal hearing and different blood groups.
Results The results of the study showed that there was a significant reduction in DPOAE amplitude for individuals with blood group O compared with individuals with other blood groups. However, there was no significant difference in ultrahigh-frequency thresholds across the blood groups.
Conclusion This reduction in OAE amplitude may be attributed to a lower number of healthy outer hair cells in individuals with blood group O. Further studies on larger groups of individuals are essential for a better generalization of the results.
Obscenity and Censorship in the Reign of Henri III
Authors: Patterson Jonathan 
Published: December 2017

AbstractThe Parisian Pierre de L’Estoile was an obsessive compiler of politically motivated, obscene ephemera during the reign of King Henri III (r. 1574–89). This article explores how and why L’Estoile kept on adding to a vast archive of “vilain” (“vile”) materials that he purportedly despised. Examining L’Estoile’s manuscripts at close quarters, the article traces a complex practice of censure and self-censorship alongside similar practices by contemporary writers (Henri Estienne and Pierre de Brantôme). L’Estoile’s contribution to the history of sexuality is that of a self-aware critic, legitimating his compulsion to disavow the obscenities he chose to preserve.
The Patronage Politics of Equestrian Ballet: Allegory, Allusion, and Satire in the Courts of Seventeenth-Century Italy and France
Authors: Goethals Jessica 
Published: December 2017

AbstractEquestrian ballet was a spectacular genre of musical theater popular in the Baroque court. A phenomenon with military roots, the ballet communicated both the might and grace of its organizers, who often played starring roles. This essay explores the ballet’s centrality by tracing the itinerant opera singer and writer Margherita Costa’s use of the genre as a means of securing elite patronage: from an elegant manuscript libretto presented to Grand Duke Ferdinando II de’ Medici and later revised in print for Cardinal Jules Mazarin in Paris, to occasional poetry written for the Barberini in Rome, and even burlesque caricatures.
Link synthetic lethality to drug sensitivity of cancer cells
Authors: Wang Ruiping , Han Yue , Zhao Zhangxiang , Yang Fan , Chen Tingting , Zhou Wenbin , Wang Xianlong , Qi Lishuang , Zhao Wenyuan , Guo Zheng , Gu Yunyan 
Published: December 2017

AbstractSynthetic lethal (SL) interactions occur when alterations in two genes lead to cell death but alteration in only one of them is not lethal. SL interactions provide a new strategy for molecular-targeted cancer therapy. Currently, there are few drugs targeting SL interactions that entered into clinical trials. Therefore, it is necessary to investigate the link between SL interactions and drug sensitivity of cancer cells systematically for drug development purpose. We identified SL interactions by integrating the high-throughput data from The Cancer Genome Atlas, small hairpin RNA data and genetic interactions of yeast. By integrating SL interactions from other studies, we tested whether the SL pairs that consist of drug target genes and the genes with genomic alterations are related with drug sensitivity of cancer cells. We found that only 6.26%∼34.61% of SL interactions showed the expected significant drug sensitivity using the pooled cancer cell line data from different tissues, but the proportion increased significantly to approximately 90% using the cancer cell line data for each specific tissue. From an independent pharmacogenomics data of 41 breast cancer cell lines, we found three SL interactions (ABL1–IFI16, ABL1–SLC50A1 and ABL1–SYT11) showed significantly better prognosis for the patients with both genes being altered than the patients with only one gene being altered, which partially supports the SL effect between the gene pairs. Our study not only provides a new way for unraveling the complex mechanisms of drug sensitivity but also suggests numerous potentially important drug targets for cancer therapy.
Endotype Transitions During the Acute Phase of Pediatric Septic Shock Reflect Changing Risk and Treatment Response
Authors: Wong Hector R. , Cvijanovich Natalie Z. , Anas Nick , Allen Geoffrey L. , Thomas Neal J. , Bigham Michael T. , Weiss Scott L. , Fitzgerald Julie C. , Checchia Paul A. , Meyer Keith , Quasney Michael , Hall Mark , Gedeit Rainer , Freishtat Robert J. , Nowak Jeffrey , Lutfi Riad , Gertz Shira , Grunwell Jocelyn R. , Lindsell Christopher J. 
Published: December 2017

Objective:
We previously identified septic shock endotypes A and B based on 100 genes reflecting adaptive immunity and glucocorticoid receptor signaling. The endotypes differ with respect to outcome and corticosteroid responsiveness. We determined whether endotypes change during the initial 3 days of illness, and whether changes are associated with outcomes.

Design:
Observational cohort study including existing and newly enrolled participants.

Setting:
Multiple PICUs.

Patients:
Children with septic shock.

Interventions:
None.

Measurements and Main Results:
We measured the 100 endotyping genes at day 1 and day 3 of illness in 375 patients. We determined if endotype assignment changes over time, and whether changing endotype is associated with corticosteroid response and outcomes. We used multivariable logistic regression to adjust for illness severity, age, and comorbidity burden. Among the 132 subjects assigned to endotype A on day 1, 56 (42%) transitioned to endotype B by day 3. Among 243 subjects assigned to endotype B on day 1, 77 (32%) transitioned to endotype A by day 3. Assignment to endotype A on day 1 was associated with increased odds of mortality. This risk was modified by the subsequent day 3 endotype assignment. Corticosteroids were associated with increased risk of mortality among subjects who persisted as endotype A.

Conclusions:
A substantial proportion of children with septic shock transition endotypes during the acute phase of illness. The risk of poor outcome and the response to corticosteroids change with changes in endotype assignment. Patients persisting as endotype A are at highest risk of poor outcomes.