bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intercambios transamericanos y transcontinentales. La recepción en internet del relato de Luis Britto García «Guaicaipuro Cuautémoc cobra la deuda a Europa»
Authors: Prieto Yurinis 
Published: January 2016

« transaméricains : la réception sur Internet de "Guaicaipuro Cuautémoc cobra la deuda a Europa" de Luis Britto Garcia, 2002-2008 »
Un texte de Luis Britto Garcia - imaginant un « Exposé du Cacique Guaicaipuro Cuautémoc devant la réunion des chefs d'États de la Communauté européenne, le 8 février 2002 » - a été diffusé sur Internet et a donné lieu à une grande diversité de forum comportant des opinions, des commentaires et des analyses. Ce corpus très riche révèle un véritable échange culturel transnational et transcontinental entre « lecteurs internautes», et fait ressortir aussi une problématique et une histoire commune : la dette externe des pays de l'Amérique latine est mise en balance avec la dette historique de l'Europe à l'égard de notre Amérique. Ces documents montrent le degré d'identification et l'adhésion des lecteurs à l'affirmation de souveraineté latino-américaine politique, économique et culturelle soutenues par le texte. Par ailleurs, la transfiguration de ce texte de fiction et sa réception confirment les potentialités de l'internet comme espace d'échanges, de diffusion, aussi bien que de création.
La política cultural de la Argentina en el Paraguay en los años previos a la Guerra del Chaco
Authors: Oliveira-Cézar María 
Published: January 2016

« La politique culturelle de l'Argentine au Paraguay dans les années qui ont précédé la guerre du Chaco»
Entre 1925 et 1931 l'action culturelle argentine au Paraguay a eu des changements substantiels liés aux divers intérêts qui l'animent. Jusqu'à fin 1927 la plupart des activités, assez modestes, sont conçues et mises en œuvre par une collectivité active de résidents argentins d'Asunciôn, parmi lesquels se détachait la personnalité de José Rodriguez Alcalé. Ces résidents y avaient créé l'Association Argentine, qui comptait sur l'appui résolu de la Légation de leur pays, dirigée alors par le ministre Leopoldo Diaz. À partir de ce moment ce sont les diplomates eux-mêmes, conduits par le nouveau ministre Ricardo Olivera, qui allaient se charger de créer et contrôler des institutions bien plus importantes, dont les conseils d'administration réunissaient des Argentins propriétaires des grandes entreprises rurales établies au long du fleuve Paraguay et la fine fleur des hommes politiques paraguayens. Deux facteurs allaient accentuer cette évolution après septembre 1930 et provoquer la militarisation des échanges « culturels » : le coup d'État du général J. F. Uriburu en Argentine et la certitude du prompt déclenchement de la guerre du Chaco.
Encuentros y desencuentros culturales en el «estrecho dudoso». La constitución del espacio rio San Juan por viajeros y escritore/as de las Américas (Ephraim G. Squier, José Coronel Urtecho, Gioconda Belli)
Authors: Esch Sophie 
Published: January 2016

« Rencontre et non-rencontre culturelles sur l'isthme "estrecho dudoso".
La constitution de l'espace du Rio San Juan par des voyageurs et écrivains et écrivaines des Amériques» La communication analyse les dynamiques culturelles autour du Rio San Juan. Ce fleuve qui fait la frontière entre le Nicaragua et le Costa Rica a été longtemps prédestiné à la construction d'un canal transocéanique à travers l'isthme centre-américain. Important axe de transit, il est aussi un espace tentant pour l'imaginaire des voyageurs et des écrivains. Dans ce cadre, les rencontres ou les non-rencontres entre écrivains des États-Unis et du Nicaragua ont constitué au fil du temps cette real-and-imagined place (Soja, 1 996). On ne peut jamais parler du rio San Juan seulement comme territoire, car il est chargé en littérature de traits imaginaires tels que utopie, paradis, etc. L'étude est menée sur des textes de Ephrain G. Squier, Mark Twain, José Coronel Urtecho et Gioconda Belli ; certains de leurs textes dialoguent l'un avec l'autre.
La melancolía como mal de la frontera y estereotipo nacional en La frontera de cristal de Carlos Fuentes
Authors: Dhondt Reindert 
Published: January 2016

« La mélancolie comme mal de la frontière : allégorie baroque et espaces d'altérité dans La frontera de cristal, de Carlos Fuentes»
Dans cet article nous nous proposons d'étudier comment la mélancolie, en tant que maladie du déplacement, produit des espaces hétérotopiques dans un certain nombre de contes de La frontière de verre (1 995) de Carlos Fuentes. Déployant une écriture dans le droit fil de la mélancolie baroque, Fuentes crée des identités nomades qui renforcent le mythe de l'état d'esprit mélancolique comme ingrédient de la culture nationale mexicaine, d'où la nécessité d'analyser le traitement de ce stéréotype national dans une oeuvre qui célèbre le nouveau contexte transnational d'après l'ALÉNA. En même temps, le concept d'« archéotopie » nous permettra d'expliquer pourquoi l'insistance sur l'espace et la frontière implique nécessairement une dimension temporelle dans ce roman.
Échanges biaisés en territoire privé. La représentation de l'espace intime dans la littérature frontalière mexicaine contemporaine
Authors: Fabriol Anaïs 
Published: January 2016

«Intercambios alterados en territorio privado. La representación del espacio intimo en la literatura fronteriza mexicana contemporanea »
Si la literatura fronteriza contemporénea se focaliza en representaciones de grandes espacios o en cuadros urbanos precisos, ambos vistos como lugares de desculturación, de metamorfosis o de intercambios enganosos, también propone unas perspectivas originales, o al menos particulares, del espacio intimo y de los intercambios que en este ambito se desarrollan. De hecho, lo que ahi sucede saca a la luz algunos elementos fundadores de lo que podria ser definido como la identidad fronteriza, asi como las aproximaciones que le pertenecen. Más que un simple detalle, el espacio privado parece ser un elemento constitutivo de la psique de algunos personajes, y por lo tanto, sirve de base a los intercambios humanos y sociales. Por lo tanto, las relaciones, los intercambios fronterizos han de ser definidos a través de este prisma, pero ino sera déformante ? ¿No habrá alguna ambigùedad en los intercambios entre huésped e invitado ? ¿Quién ganaré en estas relaciones, quién sera la victima ?
A.B.U.R.T.O. de Heriberto Yépez : Tijuanalandia ou le show de la précarité
Authors: Fourez Cathy 
Published: January 2016

«A.B.U.R.T.O.de Heriberto Yépez : Tijuanalandia o el show de los marginados»
En el contexto de una frontera que solo vive por el desplazamiento de sus limites, la ponencia estudia varios aspectos de la eonstrucciôn literaria de una ciudad : Tijuana, en la linea separatoria con los Estados Unidos. Sita en un espacio caracterizado hasta el exceso por su limite reforzado, tanto como por la porosidad de la frontera, asi como por su humanismo tanto como por su barbarie, la ciudad se estudia a través de la representaciôn de las trabajadoras de la maquiladoras. Las «Tijuanas» de Heriberto Yépez (A.B.U.R.T.O., 2005) se destacan, especialmente en la ôptica del trabajo transfronterizo y transnacional ; como unos lugares magné- ticos que desencadenan attracciôn y desconexiôn ; oscilan entre la ilusiôn de un «Las Vegas del Tercer Mundo»
y el desengano en una «maquilandia» de la mano de obra barata y desechable.
Utopía y derrota. Política y ética en la narrativa latinoamericana del fin del milenio
Authors: Amar Sánchez Ana María 
Published: January 2016

« Utopie et déroute. Politique et éthique dans la prose narrative latino-américaine
à la fin du deuxième millénaire»
Les changements politiques et économiques des dernières décennies ont donné lieu à différents discours visant à rendre compte des processus culturels complexes où le besoin de préserver la mémoire d'un passé traumatisant converge avec le besoin de rendre compte des nouvelles conditions politiques et économiques et des nouvelles productions culturelles. La communication analyse un corpus de récits latino-américains - mexicains, argentins, cubains - qui ont de nombreux points communs. Écrits dans les années quatre-vingt-dix et au commencement du nouveau millénaire, ils partagent des stratégies et des modes de représentation. Ces récits offrent diverses options - très éloignées dans la plupart des cas des solutions simplificatrices des discours politiques et médiatiques - par rapport au dilemme engendré par les déroutes politiques : la littérature latino- américaine propose des réponses allant de la résistance ou du repli au désenchantement et au fait de s'aligner ou de transiger avec ces nouvelles conditions historiques.
A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets
Authors: Tian Yuan , Cox Maureen A. , Kahan Shannon M. , Ingram Jennifer T. , Bakshi Rakesh K. , Zajac Allan J. 
Published: January 2016

Abstract
The activation of naive CD8 T cells typically results in the formation of effector cells (TE) as well as phenotypically distinct memory cells that are retained over time. Memory CD8 T cells can be further subdivided into central memory, effector memory (TEM), and tissue-resident memory (TRM) subsets, which cooperate to confer immunological protection. Using mixed bone marrow chimeras and adoptive transfer studies in which CD8 T cells either do or do not express IL-21R, we discovered that under homeostatic or lymphopenic conditions IL-21 acts directly on CD8 T cells to favor the accumulation of TE/TEM populations. The inability to perceive IL-21 signals under competitive conditions also resulted in lower levels of TRM phenotype cells and reduced expression of granzyme B in the small intestine. IL-21 differentially promoted the expression of the chemokine receptor CX3CR1 and the integrin α4β7 on CD8 T cells primed in vitro and on circulating CD8 T cells in the mixed bone marrow chimeras. The requirement for IL-21 to establish CD8 TE/TEM and TRM subsets was overcome by acute lymphocytic choriomeningitis virus infection; nevertheless, memory virus-specific CD8 T cells remained dependent on IL-21 for optimal accumulation in lymphopenic environments. Overall, this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 T cells and influencing their migratory properties, accumulation, and functions.
HB-EGF–Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse
Authors: Wang Qing , Li Hequan , Yao Yinan , Lu Guohua , Wang Yuehong , Xia Dajing , Zhou Jianying 
Published: January 2016

AbstractThe airway smooth muscle (ASM) cells’ proliferation, migration, and their progenitor’s migration are currently regarded as causative factors for ASM remodeling in asthma. Heparin-binding epidermal growth factor (HB-EGF), a potent mitogen and chemotactic factor, could promote ASM cell proliferation through MAPK pathways. In this study, we obtained primary ASM cells and their progenitors from C57BL/6 mice and went on to explore the role of HB-EGF in these cells migration and the underlying mechanisms. We found that recombinant HB-EGF (rHB-EGF) intratracheal instillation accelerated ASM layer thickening in an OVA-induced asthmatic mouse. Modified Boyden chamber assay revealed that rHB-EGF facilitate ASM cell migration in a dose-dependent manner and ASM cells from asthmatic mice had a greater migration ability than that from normal counterparts. rHB-EGF could stimulate the phosphorylation of ERK1/2 and p38 in ASM cells but further migration assay showed that only epidermal growth factor receptor inhibitor (AG1478) or p38 inhibitor (SB203580), but not ERK1/2 inhibitor (PD98059), could inhibit rHB-EGF–mediated ASM cells migration. Actin cytoskeleton experiments exhibited that rHB-EGF could cause actin stress fibers disassembly and focal adhesions formation of ASM cells through the activation of p38. Finally, airway instillation of rHB-EGF promoted the recruitment of bone marrow–derived smooth muscle progenitor cells, which were transferred via caudal vein, migrating into the airway from the circulation. These observations demonstrated that ASM remodeling in asthma might have resulted from HB-EGF–mediated ASM cells and their progenitor cells migration, via p38 MAPK-dependent actin cytoskeleton remodeling.
Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1
Authors: Rahman M. Jubayer , Rahir Gwendoline , Dong Matthew B. , Zhao Yongge , Rodrigues Kameron B. , Hotta-Iwamura Chie , Chen Ye , Guerrero Alan , Tarbell Kristin V. 
Published: January 2016

Abstract
Innate immune signals help break self-tolerance to initiate autoimmune diseases such as type 1 diabetes, but innate contributions to subsequent regulation of disease progression are less clear. Most studies have measured in vitro innate responses of GM-CSF dendritic cells (DCs) that are functionally distinct from conventional DCs (cDCs) and do not reflect in vivo DC subsets. To determine whether autoimmune NOD mice have alterations in type 1 IFN innate responsiveness, we compared cDCs from prediabetic NOD and control C57BL/6 (B6) mice stimulated in vivo with the TLR9 ligand CpG, a strong type 1 IFN inducer. In response to CpG, NOD mice produce more type 1 IFN and express higher levels of CD40, and NOD monocyte DCs make more TNF. However, the overall CpG-induced transcriptional response is muted in NOD cDCs. Of relevance the costimulatory proteins CD80/CD86, signals needed for regulatory T cell homeostasis, are upregulated less on NOD cDCs. Interestingly, NOD Rag1−/− mice also display a defect in CpG-induced CD86 upregulation compared with B6 Rag1−/−, indicating this particular innate alteration precedes adaptive autoimmunity. The impaired response in NOD DCs is likely downstream of the IFN-α/β receptor because DCs from NOD and B6 mice show similar CpG-induced CD86 levels when anti–IFN-α/β receptor Ab is added. IFN-α–induced nuclear localization of activated STAT1 is markedly reduced in NOD CD11c+ cells, consistent with lower type 1 IFN responsiveness. In conclusion, NOD DCs display altered innate responses characterized by enhanced type 1 IFN and activation of monocyte-derived DCs but diminished cDC type 1 IFN response.
Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production
Authors: Cao Yonghao , Amezquita Robert A. , Kleinstein Steven H. , Stathopoulos Panos , Nowak Richard J. , O’Connor Kevin C. 
Published: January 2016

Abstract
Myasthenia gravis (MG) is a prototypical autoimmune disease that is among the few for which the target Ag and the pathogenic autoantibodies are clearly defined. The pathology of the disease is affected by autoantibodies directed toward the acetylcholine receptor (AChR). Mature, Ag-experienced B cells rely on the action of Th cells to produce these pathogenic Abs. The phenotype of the MG Ag-reactive T cell compartment is not well defined; thus, we sought to determine whether such cells exhibit both a proinflammatory and a pathogenic phenotype. A novel T cell library assay that affords multiparameter interrogation of rare Ag-reactive CD4+ T cells was applied. Proliferation and cytokine production in response to both AChR and control Ags were measured from 3120 T cell libraries derived from 11 MG patients and paired healthy control subjects. The frequency of CCR6+ memory T cells from MG patients proliferating in response to AChR-derived peptides was significantly higher than that of healthy control subjects. Production of both IFN-γ and IL-17, in response to AChR, was also restricted to the CCR6+ memory T cell compartment in the MG cohort, indicating a proinflammatory phenotype. These T cells also included an elevated expression of GM-CSF and absence of IL-10 expression, indicating a proinflammatory and pathogenic phenotype. This component of the autoimmune response in MG is of particular importance when considering the durability of MG treatment strategies that eliminate B cells, because the autoreactive T cells could renew autoimmunity in the reconstituted B cell compartment with ensuing clinical manifestations.
CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis
Authors: Roan Florence , Stoklasek Thomas A. , Whalen Elizabeth , Molitor Jerry A. , Bluestone Jeffrey A. , Buckner Jane H. , Ziegler Steven F. 
Published: January 2016

Abstract
Innate lymphoid cells (ILC) are a heterogeneous group of cellular subsets that produce large amounts of T cell–associated cytokines in response to innate stimulation in the absence of Ag. In this study, we define distinct patterns of surface marker and cytokine expression among the ILC subsets that may further delineate their migration and function. Most notably, we found that the subset previously defined as group 1 ILC (ILC1) contains CD4+ CD8−, CD4− CD8+, and CD4− CD8− populations. Although all ILC1 subsets shared characteristics with Th1 cells, CD4+ ILC1 also demonstrated significant phenotypic and functional heterogeneity. We also show that the frequencies of CD4+ ILC1 and NKp44+ group 3 ILC, but not CD4− ILC1 or group 2 ILC, are increased in the peripheral blood of individuals with systemic sclerosis (SSc), a disease characterized by fibrotic and vascular pathology, as well as immune dysregulation. Furthermore, we demonstrate that CD4+ and CD4− ILC1 are functionally divergent based on their IL-6Rα expression and that the frequency of IL-6Rα expression on ILC is altered in SSc. The distinct phenotypic and functional features of CD4+ and CD4− ILC1 suggest that they may have differing roles in the pathogenesis of immune-mediated diseases, such as SSc.
Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses
Authors: Bajwa Gagan , DeBerardinis Ralph J. , Shao Baomei , Hall Brian , Farrar J. David , Gill Michelle A. 
Published: January 2016

Abstract
Plasmacytoid dendritic cells (pDCs) are vital to antiviral defense, directing immune responses via secretion of huge concentrations of IFN-α. These cells are critical in protecting the lung against clinically relevant respiratory viruses, particularly influenza (Flu), a virus responsible for substantial worldwide morbidity and mortality. How pDC responses to such viral pathogens are regulated, however, is poorly understood in humans. Using an unbiased approach of gene chip analysis, we discovered that Flu significantly affects metabolism in primary human pDCs. We demonstrate that Flu and RV, another common respiratory virus, induce glycolysis in pDCs and that this metabolic pathway regulates pDC antiviral functions, including IFN-α production and phenotypic maturation. Intranasal vaccination of human volunteers with live influenza virus also increases glycolysis in circulating pDCs, highlighting a previously unrecognized potential role for metabolism in regulating pDC immune responses to viral infections in humans.
Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells
Authors: Grégoire Sylvie , Terrada Céline , Martin Gaelle H. , Fourcade Gwladys , Baeyens Audrey , Marodon Gilles , Fisson Sylvain , Billiard Fabienne , Lucas Bruno , Tadayoni Ramin , Béhar-Cohen Francine , Levacher Béatrice , Galy Anne , LeHoang Phuc , Klatzmann David , Bodaghi Bahram , Salomon Benoît L. 
Published: January 2016

Abstract
CD4+CD25+Foxp3+ regulatory T (Treg) cell therapy is a promising approach for the treatment of autoimmune diseases. To be effective, Treg cells should be in an activated state in the target tissue. This can be achieved by systemic administration of Ag-specific Treg cells, which are difficult to produce in conditions that can be translated to the clinic. In this paper, we propose an alternative approach consisting of in situ injection of preactivated polyclonal Treg cells that would exert bystander suppression in the target tissue. We show that polyclonal Treg cells suppressed uveitis in mice as efficiently as Ag-specific Treg cells but only when preactivated and administered in the vitreous. Uveitis control was correlated with an increase of IL-10 and a decrease of reactive oxygen species produced by immune cell infiltrates in the eye. Thus, our results reveal a new mechanism of Treg cell–mediated suppression and a new Treg cell therapy approach.
MicroRNA-30c Modulates Type I IFN Responses To Facilitate Porcine Reproductive and Respiratory Syndrome Virus Infection by Targeting JAK1
Authors: Zhang Qiong , Huang Chen , Yang Qian , Gao Li , Liu Hsiao-Ching , Tang Jun , Feng Wen-hai 
Published: January 2016

Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen and has evolved several mechanisms to evade IFN-I responses. We report that a host microRNA, miR-30c, was upregulated by PRRSV via activating NF-κB and facilitated its ability to infect subject animals. Subsequently, we demonstrated that miR-30c was a potent negative regulator of IFN-I signaling by targeting JAK1, resulting in the enhancement of PRRSV infection. In addition, we found that JAK1 expression was significantly decreased by PRRSV and recovered when miR-30c inhibitor was overexpressed. Importantly, miR-30c was also upregulated by PRRSV infection in vivo, and miR-30c expression corresponded well with viral loads in lungs and porcine alveolar macrophages of PRRSV-infected pigs. Our findings identify a new strategy taken by PRRSV to escape IFN-I–mediated antiviral immune responses by engaging miR-30c and, thus, improve our understanding of its pathogenesis.
Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2
Authors: Vašl Jožica , Oblak Alja , Peternelj Tina T. , Klett Javier , Martín-Santamaría Sonsoles , Gioannini Theresa L. , Weiss Jerrold P. , Jerala Roman 
Published: January 2016

Abstract
Myeloid differentiation factor 2 (MD-2) is an extracellular protein, associated with the ectodomain of TLR4, that plays a critical role in the recognition of bacterial LPS. Despite high overall structural and functional similarity, human (h) and murine (m) MD-2 exhibit several species-related differences. hMD-2 is capable of binding LPS in the absence of TLR4, whereas mMD-2 supports LPS responsiveness only when mMD-2 and mTLR4 are coexpressed in the same cell. Previously, charged residues at the edge of the LPS binding pocket have been attributed to this difference. In this study, site-directed mutagenesis was used to explore the hydrophobic residues within the MD-2 binding pocket as the source of functional differences between hMD-2 and mMD-2. Whereas decreased hydrophobicity of residues 61 and 63 in the hMD-2 binding pocket retained the characteristics of wild-type hMD-2, a relatively minor change of valine to alanine at position 135 completely abolished the binding of LPS to the hMD-2 mutant. The mutant, however, retained the LPS binding in complex with TLR4 and also cell activation, resulting in a murine-like phenotype. These results were supported by the molecular dynamics simulation. We propose that the residue at position 135 of MD-2 governs the dynamics of the binding pocket and its ability to accommodate lipid A, which is allosterically affected by bound TLR4.