bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Cyanoacetic Acid as a Masked Electrophile: Transition‐Metal‐Free Cyanomethylation of Amines and Carboxylic Acids.
Authors: Wang Hongxiang , Shao Ying , Zheng Hao , Wang Hanghang , Cheng Jiang , Wan Xiaobing 
Published: April 2016

AbstractA novel cyanomethylation reaction of primary aromatic amines, secondary, and even tertiary amines as well as of carboxylic acids is described.
ChemInform Abstract: Iodine‐Mediated Copper‐Catalyzed Efficient α‐C(sp2)‐Thiomethylation of α‐Oxoketene Dithioacetals with Dimethyl Sulfoxide in One Pot.
Authors: Shukla Gaurav , Srivastava Abhijeet , Nagaraju Anugula , Raghuvanshi Keshav , Singh Maya Shankar 
Published: April 2016

AbstractThis operationally simple one‐pot protocol includes region‐defined consecutive iodination and sulfenylation of the challenging α‐C(sp2)—H bond of dithioacetals employing cheap and readily available reagents.
ChemInform Abstract: Nickel(0)/N‐Heterocyclic Carbene‐Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Two Enones and an Alkyne: Access to Cyclohexenes with Four Contiguous Stereogenic Centers.
Authors: Kumar Ravindra , Tokura Hiromu , Nishimura Akira , Mori Tadashi , Hoshimoto Yoichi , Ohashi Masato , Ogoshi Sensuke 
Published: April 2016

AbstractA diastereoselective access to cyclohexenes bearing four contiguous stereogenic centers through enantioselective [2 + 2 + 2] cycloaddition of two enones and one alkyne is developed.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Tropone and Its Analogues via Oxidative Ring Expansion of Alkynyl Quinols.
Authors: Zhao Jidong , Liu Jun , Xie Xin , Li Shi , Liu Yuanhong 
Published: April 2016

AbstractThe new and convenient regioselective strategy allows access to seven and six‐membered ring systems including tropones, benzotropones, benzoxepines, phenanthrenes and quinolin‐2(1H)ones.
ChemInform Abstract: Highly Enantioselective Aza‐Michael Reaction Between Alkyl Amines and β‐Trifluoromethyl β‐Aryl Nitroolefins.
Authors: Wang Leming , Chen Jiean , Huang Yong 
Published: April 2016

AbstractChiral N‐heterocyclic carbenes are used as noncovalent organocatalysts for the highly selective aza‐Michael addition between primary alkyl amines and various nitroolefins affording chiral trifluoromethylated amines.
ChemInform Abstract: Catalytic Conjunctive Cross‐Coupling Enabled by Metal‐Induced Metallate Rearrangement.
Authors: Zhang Liang , Lovinger Gabriel J. , Edelstein Emma K. , Szymaniak Adam A. , Chierchia Matteo P. , Morken James P. 
Published: April 2016

AbstractVinyl boronic ester ate complexes, synthesized from organoboronates and organolithium reagents, are involved in palladium‐induced metallate rearrangements wherein an 1,2‐migration of an alkyl/aryl group from boron to the vinyl α‐carbon takes place simultaneously with a C—Pd σ‐bond formation.
ChemInform Abstract: Ring‐Opening of Pyridines with Acylacetylenes and Water: Straightforward Access to 5‐[(Z)‐Acylethenyl]amino‐2,4‐pentadienals.
Authors: Trofimov Boris A. , Andriyankova Ludmila V. , Belyaeva Kseniya V. , Nikitina Lina P. , Afonin Andrei V. , Mal'kina Anastasiya G. 
Published: April 2016

AbstractA hitherto unknown family of Zincke aldehydes is obtained.
ChemInform Abstract: Iridium‐Catalyzed Enantioselective Allylic Substitution of Enol Silanes from Vinylogous Esters and Amides.
Authors: Chen Ming , Hartwig John F. 
Published: April 2016

AbstractEnol silanes of vinylogous esters and amides react as nucleophiles with a wide range of allylic carbonates affording the allylated products with high enantioselectivities and excellent branched‐to‐linear ratios.
ChemInform Abstract: Design of Supported Organocatalysts from Carboxylic Acids for the Mannich‐Type Synthesis of β‐amino Carbonyl Compounds.
Authors: Sarma Parishmita , Saikia Susmita , Borah Ruli 
Published: April 2016

Abstractβ‐Amino carbonyl compounds (IV) are selectively synthesized via Mannich‐type reactions using silica‐supported trifluoroacetic acid as highly efficient reusable catalyst.
ChemInform Abstract: Nickel‐Catalyzed Arylation of Heteroaryl‐Containing Diarylmethanes: Exceptional Reactivity of the Ni(NIXANTPHOS)‐Based Catalyst.
Authors: Cao Xinyu , Sha Sheng‐Chun , Li Minyan , Kim Byeong‐Seon , Morgan Catherine , Huang Rudan , Yang Xiaodong , Walsh Patrick J. 
Published: April 2016

AbstractIn most cases, educts bearing one aryl and one pyridyl residue are used for the preparation of the desired triarylmethane products.
ChemInform Abstract: Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols.
Authors: Barbato Keith S. , Luan Yi , Ramella Daniele , Panek James S. , Schaus Scott E. 
Published: April 2016

AbstractConditions for the chemoselective formation of either chiral di‐ and triarylmethane products or chiral 2,4‐diaryl chromans are developed.
ChemInform Abstract: Asymmetric Synthesis of Spiroketals with Aminothiourea Catalysts.
Authors: Yoneda Naoki , Fukata Yukihiro , Asano Keisuke , Matsubara Seijiro 
Published: April 2016

AbstractThe intramolecular bis‐cyclization of α,β‐unsaturated carbonyl compounds (I) tethered with an hydroxy substituted alkylketone side chain is optimized in the presence of bifunctional thiourea catalyst to give spiroketals.
ChemInform Abstract: Synthesis of Difluoroalkyl‐γ‐butyrolactones from Iododifluoromethyl Ketones and 4‐Pentenoic Acids.
Authors: Wang Jie‐Xiong , Wu Jing‐Jing , Chen Heng , Zhang Shao‐Wu , Wu Fan‐Hong 
Published: April 2016

AbstractThe title lactones are efficiently obtained by radical addition reaction of aromatic iododifluoromethyl ketones with pentenoic acids involving a sequential radical difluoroalkylation and nucleophilic cyclization.
ChemInform Abstract: Pyridazine N‐Oxides as Precursors of Metallocarbenes: Rhodium‐Catalyzed Transannulation with Pyrroles.
Authors: Kanchupalli Vinaykumar , Joseph Desna , Katukojvala Sreenivas 
Published: April 2016

AbstractThe synthetic utility of the novel approach is demonstrated by the two‐step transformation of one product into the antiproliferative agent (VI).
ChemInform Abstract: A [4 + 1] Cyclative Capture Approach to 3H‐Indole‐N‐oxides at Room Temperature by Rhodium(III)‐Catalyzed C—H Activation.
Authors: Yang Yaxi , Wang Xuan , Li Yuanchao , Zhou Bing 
Published: April 2016

AbstractVarious indole‐N‐oxides are obtained by [4+1] C—H oxidative cyclization of nitrones with diazo compounds.
ChemInform Abstract: Asymmetric Broensted Acid Catalyzed Synthesis of Triarylmethanes—Construction of Communesin and Spiroindoline Scaffolds.
Authors: Liao Hsuan‐Hung , Chatupheeraphat Adisak , Hsiao Chien‐Chi , Atodiresei Iuliana , Rueping Magnus 
Published: April 2016

AbstractThe functionalization of indoles with alcohols (II) proceeds with high enantioselectivity to give triarylmethanes (III) and (VI).
ChemInform Abstract: Catalytic Enantioselective Arylative Dearomatization of 3‐Methyl‐2‐vinylindoles Enabled by Reactivity Switch.
Authors: Wang Yang , Sun Meng , Yin Lei , Shi Feng 
Published: April 2016

AbstractThe first catalytic asymmetric dearomatization of 3‐methyl‐2‐vinylindoles is established by using quinone monoimides as suitable electrophiles in the presence of a chiral phosphoric acid, which affords chiral indole derivatives bearing a quaternary stereogenic center in a chemospecific and highly enantioselective fashion.
ChemInform Abstract: Synthesis of (E)‐Oxindolylidene Acetate Using Tandem Palladium‐Catalyzed Heck and Alkoxycarbonylation Reactions.
Authors: Lin Wei‐Jen , Shia Kak‐Shan , Song Jen‐Shin , Wu Ming‐Hsien , Li Wen‐Tai 
Published: April 2016

AbstractA tandem Pd‐catalyzed Heck and alkoxycarbonylation reaction for the stereoselective synthesis of (E)‐oxindolylidene acetates is presented.
ChemInform Abstract: A Highly Enantioselective Thiolation of Sulfonyl Indoles to Access 3‐sec‐Sulfur‐Substituted Indoles in Water.
Authors: Chen Ping , Lu Sheng‐mei , Guo Wengang , Liu Yan , Li Can 
Published: April 2016

AbstractVinylogous imine intermediates generated in situ from sulfonylindoles undergo asymmetric 1,4‐addition with trityl mercaptan (I) to form the title compounds with good to excellent enantioselectivities.
ChemInform Abstract: Synthesis of Isatins by the Palladium‐Catalyzed Intramolecular Acylation of Unactivated Aryl C(sp2)—H Bonds.
Authors: Li Jue , Zheng Yang , Yu Xinling , Lv Songyang , Wang Qiantao , Hai Li , Wu Yong 
Published: April 2016

AbstractUsing air as the oxidant, the PdCl2‐catalyzed intramolecular cyclization of N‐alkylglyoxalanilides gives the corresponding isatins in good to high yields.
ChemInform Abstract: Enantioselective Synthesis of Hemiaminals via Pd‐Catalyzed C—N Coupling with Chiral Bisphosphine Mono‐Oxides.
Authors: Li Hongming , Belyk Kevin M. , Yin Jingjun , Chen Qinghao , Hyde Alan , Ji Yining , Oliver Steven , Tudge Matthew T. , Campeau Louis‐Charles , Campos Kevin R. 
Published: April 2016

AbstractA novel approach to the enantioselective synthesis of hemiaminals via Pd‐catalyzed C—N coupling using commercially available chiral bisphosphine ligands is developed.
ChemInform Abstract: Gold(I)‐Catalyzed Dearomative [2 + 2]‐Cycloaddition of Indoles with Activated Allenes: A Combined Experimental—Computational Study.
Authors: Ocello Riccardo , De Nisi Assunta , Jia Minqiang , Yang Qing‐Qing , Monari Magda , Giacinto Pietro , Bottoni Andrea , Miscione Gian Pietro , Bandini Marco 
Published: April 2016

AbstractThe scope of the reaction encompasses both allenamides and aryloxyallenes as electrophilic partners.
ChemInform Abstract: Diversification of Edaravone via Palladium‐Catalyzed Hydrazine Cross‐Coupling: Applications Against Protein Misfolding and Oligomerization of Beta‐Amyloid.
Authors: MacLean Mark A. , Diez‐Cecilia Elena , Lavery Christopher B. , Reed Mark A. , Wang Yanfei , Weaver Donald F. , Stradiotto Mark 
Published: April 2016

AbstractA library of 21 N‐aryl derivatives of edaravone is obtained by palladium‐catalyzed hydrazine monoarylation.
ChemInform Abstract: The First Example of an Unusual Rearrangement in the van Leusen Imidazole Synthesis.
Authors: Fodili Mokhtar , Nedjar‐Kolli Bellara , Vedrenne Marc , Saffon‐Merceron Nathalie , Lherbet Christian , Hoffmann Pascal 
Published: April 2016

AbstractThe imidazole ring system (V) can be prepared by reaction of TosMIC (IV) with a tautomeric enamine form (III) of a secondary ketimine.
ChemInform Abstract: A Facile Synthesis of 2,5‐Disubstituted Oxazoles via a Copper‐Catalyzed Cascade Reaction of Alkenes with Azides.
Authors: Li Jiu‐ling , Wang Ying‐chun , Li Wei‐ze , Wang Heng‐shan , Mo Dong‐liang , Pan Ying‐ming 
Published: April 2016

AbstractDisubstituted oxazoles are synthesized via a novel and efficient method including 1,3‐dipolar cycloaddition/ring cleavage/1,2‐H migration/denitrogenation/copper‐catalyzed aerobic oxidative dehydrogenative cyclization cascade.
ChemInform Abstract: Silver‐Catalyzed Cyclization of Propargylic Amides to Oxazolines.
Authors: Wong Valerie H. L. , White Andrew J. P. , Hor T. S. Andy , Hii King Kuok Mimi 
Published: April 2016

AbstractA ligand‐accelerated effect is observed in the cyclization of propargylic amides catalyzed by bis(pyridyl)silver(I) complexes, with an unexpected reversal of electronic demand to the analogous N—H addition reaction.
ChemInform Abstract: Metal‐Free Intermolecular Azide‐Alkyne Cycloaddition Promoted by Glycerol.
Authors: Rodriguez‐Rodriguez Marta , Gras Emmanuel , Pericas Miquel A. , Gomez Montserrat 
Published: April 2016

AbstractThe effect of glycerol in these metal‐free intermolecular Huisgen cycloadditions is rationalized with the help of DFT calculations.
ChemInform Abstract: Aldol Additions of Titanium and Boron Enolates of Achiral and Chiral δ‐Lactones to Achiral Model Aldehydes: Simple and Induced Diastereoselectivities.
Authors: Weber Fabian , Becker Fabian , Keller Manfred , Hillebrecht Harald , Brueckner Reinhard 
Published: April 2016

AbstractIt is found that titanium enolates in most cases syn‐selectively react with achiral aldehydes, whereas boron enolates react anti‐selectively in all cases.
ChemInform Abstract: Asymmetric Synthesis of 3,4‐Dihydrocoumarins Bearing an α,α‐Disubstituted Amino Acid Moiety.
Authors: Hejmanowska Joanna , Albrecht Anna , Pieta Jakub , Albrecht Lukasz 
Published: April 2016

AbstractAn organocatalytic approach for the stereoselective synthesis of 3,4‐dihydrocoumarins with an α,α‐disubstituted amino acid moiety incorporated is presented.
ChemInform Abstract: The Regioselective Iodination of Quinolines, Quinolones, Pyridones, Pyridines and Uracil.
Authors: Dutta Uttam , Deb Arghya , Lupton David W. , Maiti Debabrata 
Published: April 2016

AbstractThe title iodination is a radical based direct C—H iodination, which occurs at C3 or/and C5 position depending on the substrates.
ChemInform Abstract: Regioselective Synthesis of 1,2‐ and 1,4‐Dihydroquinolines by Palladium‐Catalyzed Intramolecular N‐Arylation.
Authors: Park Kyeong‐Yong , Lee Jinyong , Park Seong Jun , Heo Jung‐Nyoung , Lim Hwan Jung 
Published: April 2016

AbstractA series of 1,2‐ and 1,4‐dihydroquinolines is prepared by Pd‐catalyzed intramolecular N‐arylation of Z‐enamines, formally prepared by the Horner—Wadsworth—Emmons olefination.
ChemInform Abstract: One‐Pot Dichotomous Construction of Inside‐Azayohimban and Pro‐Azayohimban Systems via an Enantioselective Organocatalytic Cascade; Their Use as a Model to Probe the (Aza‐)Indole Local Solvent Environment.
Authors: Yang Van‐Wei , Hong Bor‐Cherng , Kao Hsin‐Kai , Tu Ting‐Hsun , Shen Jiun‐Yi , Chen Chi‐Lin , Lee Gene‐Hsiang , Chou Pi‐Tai 
Published: April 2016

AbstractFive contiguous stereocenters containing inside‐azayohimban (X) and pro‐azayohimban (IVa) as well as derivatives thereof are prepared and their photochemical properties are examined.
ChemInform Abstract: Tetraalkylammonium Salts as Hydrogen‐Bonding Catalysts.
Authors: Shirakawa Seiji , Liu Shiyao , Kaneko Shiho , Kumatabara Yusuke , Fukuda Airi , Omagari Yumi , Maruoka Keiji 
Published: April 2016

AbstractNewly designed tetraalkylammonium salts (TAS) are investigated as hydrogen‐bonding catalysts for coupling reactions of chlorodihydroisoquinolines (I) with ketene acetals (II) or silyl enol ethers (IV).
ChemInform Abstract: One‐Pot, Facile, Highly Efficient, and Green Synthesis of Acridinedione Derivatives Using Vitamin B1.
Authors: Isik Ahmet , Aday Burak , Ulus Ramazan , Kaya Muharrem 
Published: April 2016

AbstractTitle compounds (IV) are efficiently synthesized through a one‐pot multicomponent condensation in the presence of the easily available, inexpensive, and nontoxic catalyst vitamin B1.
ChemInform Abstract: Core‐Scaffold‐Inspired Asymmetric Synthesis of Polysubstituted Chiral Hexahydropyridazines that Potently Inhibit Breast Cancer Cell Proliferation by Inducing Apoptosis.
Authors: Leng Hai‐Jun , Peng Fu , Zingales Sarah , Huang Wei , Wang Biao , Zhao Qian , Zhou Rui , He Gu , Peng Cheng , Han Bo 
Published: April 2016

AbstractThis asymmetric cascade approach utilizes an organocatalytic Michael reaction followed by intermolecular α‐amination and intramolecular hemiaminalization to yield chiral pyridazines with four or five contiguous stereogenic centers.
ChemInform Abstract: Green and Catalyst‐Free One‐Pot Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones in Water.
Authors: Olyaei Abolfazl , Rahbarian Fatemeh , Sadeghpour Mahdieh 
Published: April 2016

AbstractA simple, highly efficient and straightforward method for the formation of the title compounds via three‐component coupling reactions of isatoic anhydride with aromatic aldehydes and aniline or NH4OAc is developed.
ChemInform Abstract: Metal‐Free [4 + 2] Annulation of Arylalkynes with tert‐Butyl Nitrite Through C(sp2)—H Oxidation to Assemble Benzo[e][1,2]oxazin‐4‐ones.
Authors: Yang Xu‐Heng , Song Ren‐Jie , Li Jin‐Heng 
Published: April 2016

AbstractA metal‐free radical‐mediated [4+2] annulation of internal arylalkynes with tert‐butyl nitrite is presented for the synthesis of benzoxazinones through the addition of t‐BuONO across the CC triple bond, hydration, isomerization, and aromatic C(sp2)—H oxidation cascades.
ChemInform Abstract: Modular Access to the Stereoisomers of Fused Bicyclic Azepines: Rhodium‐Catalyzed Intramolecular Stereospecific Hetero‐[5 + 2] Cycloaddition of Vinyl Aziridines and Alkenes.
Authors: Feng Jian‐Jun , Lin Tao‐Yan , Wu Hai‐Hong , Zhang Junliang 
Published: April 2016

AbstractThe title method provides fused azepine derivatives having multiple contiguous stereogenic centers.
ChemInform Abstract: Enantioselective Construction of the Biologically Important Cyclopenta[1,4]diazepine Framework Enabled by Asymmetric Catalysis by Chiral Spiro‐Phosphoric Acid.
Authors: Sun Meng , Wang Yang , Yin Lei , Cao Yang‐Yan , Shi Feng 
Published: April 2016

AbstractThe first catalytic asymmetric construction of the chiral title diazepines by three‐component tandem reactions of cyclopentanedione, phenylenediamine, and various isatins under mild reaction conditions using a chiral spiro‐phosphoric acid catalyst is presented.
ChemInform Abstract: The Synthesis of Structurally Diverse Macrocycles by Successive Ring Expansion.
Authors: Kitsiou Christiana , Hindes Jordan J. , I'Anson Phillip , Jackson Paula , Wilson Thomas C. , Daly Eleanor K. , Felstead Hannah R. , Hearnshaw Peter , Unsworth William P. 
Published: April 2016

AbstractMgCl2‐ and pyridine‐promoted α‐acylation of cyclic β‐ketoesters [cf.
ChemInform Abstract: Palladium‐Catalyzed Regio‐ and Chemoselective Reactions of 2‐Bromobenzyl Bromides: Expanding the Scope for the Synthesis of Biaryls Fused to a Seven‐Membered Sultam.
Authors: Laha Joydev K. , Sharma Shubhra , Dayal Neetu 
Published: April 2016

AbstractThe title sultams are rapidly and easily obtained starting from readily accessible N‐alkyl‐benzenesulfonamides and bromobenzylbromides by domino reaction involving an N‐benzylation followed by an intramolecular direct C—H arylation ortho to the sulfonamide group.
ChemInform Abstract: Acylsilanes in Iridium‐Catalyzed Directed Amidation Reactions and Formation of Heterocycles via Siloxycarbenes.
Authors: Becker Peter , Pirwerdjan Ramona , Bolm Carsten 
Published: April 2016

AbstractA highly efficient ortho‐amidation of aroylsilanes with sulfonyl azides is developed.
ChemInform Abstract: Triflimide‐Catalyzed Rearrangement of N‐(1‐Trimethylsilyl)allylhydrazones Results in the Formation of Vinylsilanes and Cyclopropanes.
Authors: Dittrich Sebastian , Bracher Franz 
Published: April 2016

AbstractTerminal vinylsilanes are obtained by triflimide‐catalyzed rearrangement of the title hydrazones.
ChemInform Abstract: Facile Alder‐Ene Reactions of Silylallenes Involving an Allenic C(sp2)—H Bond.
Authors: Sabbasani Venkata R. , Huang Genping , Xia Yuanzhi , Lee Daesung 
Published: April 2016

AbstractA silyl substituent is critical for the observed reactivity and selectivity in the Alder‐ene reactions of silylallenes with azodicarboxylate, ethyl glyoxylate, or benzyne.
ChemInform Abstract: Selective Alkenylation and Hydroalkenylation of Enol Phosphates Through Direct C—H Functionalization.
Authors: Hu Xu‐Hong , Yang Xiao‐Fei , Loh Teck‐Peng 
Published: April 2016

AbstractThe first Rh‐catalyzed cross‐coupling reactions of enol phosphates with a variety of activated alkenes and propyne derivatives (XIV) are described.
ChemInform Abstract: ent‐Abietane‐Type Diterpenoids from the Roots of Euphorbia ebracteolata with Their Inhibitory Activities on LPS‐Induced NO Production in RAW 264.7 Macrophages.
Authors: Liu Zhi‐guo , Li Zhan‐lin , Li Da‐hong , Li Ning , Bai Jiao , Zhao Feng , Meng Da‐li , Hua Hui‐ming 
Published: April 2016

AbstractFour new ent‐abietane diterpenoids, ebractenoids K—N, are isolated along with six known ones from the roots of Euphorbia ebracteolata.
ChemInform Abstract: Sesquiterpenes and Prenylated C6—C3 Compounds from the Stems of Illicium henryi.
Authors: Zhuang Peng‐Yu , Zhang Gui‐Jie , Wang Xiao‐Jing , Zhang Yan , Yu Shi‐Shan 
Published: April 2016

AbstractOne new sesquiterpene, illihenlactone A (I), and a new prenylated sesquiterpene, illihenryione H (II), are isolated along with three known sesquiterpenes.
ChemInform Abstract: A Novel Selectfluor‐Mediated Regioselective O‐Benzyl Ether Acetolysis of Perbenzylated Monosaccharides.
Authors: Tambie Marlon S. , Jalsa Nigel Kevin 
Published: April 2016

AbstractSelectfluor‐mediated benzyl group acetolysis is proved to be a mild and easy method to obtain partially benzylated and partially acetylated carbohydrates.
ChemInform Abstract: Diffusion‐Assisted Synthesis of Co2FeSn Heusler Nanoparticles and Their Magnetic Properties.
Authors: Li Pengpeng , Kou Xinli 
Published: April 2016

AbstractCo2FeSn Heusler nanoparticles (5—12 nm particle size) are prepared by boiling Co2Fe and Sn nanoparticles in tetraethylene glycol (stirring, 230 °C, 24 h) which results in diffusion of molten Sn into Co2Fe nanoparticles.
ChemInform Abstract: Palladium‐Catalyzed Oxyarylation, Azaarylation and α‐Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues
Authors: Buarque Camilla D. , Domingos Jorge L. O. , Netto Chaquip D. , Costa Paulo R. R. 
Published: April 2016

AbstractReview: 132 refs.
Neighbor palatability generates associational effects by altering herbivore foraging behavior
Authors: Hahn Philip G. , Orrock John L. 
Published: April 2016

AbstractDespite increasing evidence that herbivory on a focal plant may hinge upon the identity of its neighbors, it is not clear whether predictable mechanisms govern the nature and magnitude of such associational effects. Using a factorial field experiment replicated at 14 sites across 80,000 hectares, we evaluated the mechanisms driving associational effects between two plant species mediated by grasshopper herbivores. Our experiment manipulated local neighborhood plant density (two levels) and frequency (three levels), nested within two larger‐scale habitat contexts (habitats that did or did not have past agricultural land use). We found that the more palatable plant species, Solidago nemoralis, experienced reduced herbivory (associational resistance) when rare due mainly to reduced grasshopper foraging activity. Damage to the less palatable plant species, S. odora, was affected by the interaction between plant frequency and the land‐use history of the site: it experienced increased damage (associational susceptibility) in even‐frequency neighborhoods, but only in sites with a history of agricultural use. Behavioral assays generally corroborated the results from the field, further supporting the importance of foraging behavior in generating associational effects. In finding that associational effects are contingent upon relative palatability among plants and events in the distant past that modify contemporary habitat structure (i.e., past agricultural land use), our work suggests that foraging decisions made at the neighborhood level are important for generating associational effects and that in some cases these neighborhood interactions also depend on the larger‐scale environmental context resulting from legacies of past land‐use events.