bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and regime shifts in climatic conditions and river runoff in Estonia during 1951–2015
Authors: Jaagus Jaak , Sepp Mait , Tamm Toomas , Järvet Arvo , Mõisja Kiira 
Published: November 2017

Abstract. Time series of monthly, seasonal and annual mean air temperature, precipitation, snow cover duration and specific runoff of rivers in Estonia are analysed for detecting of trends and regime shifts during 1951–2015. Trend analysis is realised using the Mann–Kendall test and regime shifts are detected with the Rodionov test (sequential t-test analysis of regime shifts). The results from Estonia are related to trends and regime shifts in time series of indices of large-scale atmospheric circulation. Annual mean air temperature has significantly increased at all 12 stations by 0.3–0.4 K decade−1. The warming trend was detected in all seasons but with the higher magnitude in spring and winter. Snow cover duration has decreased in Estonia by 3–4 days decade−1. Changes in precipitation are not clear and uniform due to their very high spatial and temporal variability. The most significant increase in precipitation was observed during the cold half-year, from November to March and also in June. A time series of specific runoff measured at 21 stations had significant seasonal changes during the study period. Winter values have increased by 0.4–0.9 L s−1 km−2 decade−1, while stronger changes are typical for western Estonia and weaker changes for eastern Estonia. At the same time, specific runoff in April and May have notably decreased indicating the shift of the runoff maximum to the earlier time, i.e. from April to March. Air temperature, precipitation, snow cover duration and specific runoff of rivers are highly correlated in winter determined by the large-scale atmospheric circulation. Correlation coefficients between the Arctic Oscillation (AO) and North Atlantic Oscillation (NAO) indices reflecting the intensity of westerlies, and the studied variables were 0.5–0.8. The main result of the analysis of regime shifts was the detection of coherent shifts for air temperature, snow cover duration and specific runoff in the late 1980s, mostly since the winter of 1988/1989, which are, in turn, synchronous with the shifts in winter circulation. For example, runoff abruptly increased in January, February and March but decreased in April. Regime shifts in annual specific runoff correspond to the alternation of wet and dry periods. A dry period started in 1964 or 1963, a wet period in 1978 and the next dry period at the beginning of the 21st century.
DebrisInterMixing-2.3: a finite volume solver for three-dimensional debris-flow simulations with two calibration parameters – Part 2: Model validation with experiments
Authors: von Boetticher Albrecht , Turowski Jens M. , McArdell Brian W. , Rickenmann Dieter , Hürlimann Marcel , Scheidl Christian , Kirchner James W. 
Published: November 2017

Abstract. Here, we present validation tests of the fluid dynamic solver presented in von Boetticher et al. (2016), simulating both laboratory-scale and large-scale debris-flow experiments. The new solver combines a Coulomb viscoplastic rheological model with a Herschel–Bulkley model based on material properties and rheological characteristics of the analyzed debris flow. For the selected experiments in this study, all necessary material properties were known – the content of sand, clay (including its mineral composition) and gravel as well as the water content and the angle of repose of the gravel. Given these properties, two model parameters are sufficient for calibration, and a range of experiments with different material compositions can be reproduced by the model without recalibration. One calibration parameter, the Herschel–Bulkley exponent, was kept constant for all simulations. The model validation focuses on different case studies illustrating the sensitivity of debris flows to water and clay content, channel curvature, channel roughness and the angle of repose. We characterize the accuracy of the model using experimental observations of flow head positions, front velocities, run-out patterns and basal pressures.
Cauterization of Ozurdex wound for the prevention of scleral leakage in vitrectomized eyes
Authors: Furino Claudio , Recchimurzo Nicola , Boscia Francesco , Alessio Giovanni 
Published: November 2017

Purpose: To study if cauterization of the scleroconjuctival wound secondary to intravitreal dexamethasone implant in vitrectomized eyes is effective to avoid scleral leakage and hypotony. Methods: A total of 35 vitrectomized eyes of 35 consecutive patients with macular edema who underwent a single intravitreal dexamethasone implant injection in the operating room at the Eye Clinic of the University of Bari, Italy, from 2013 to 2017 were retrospectively reviewed. At the end of the injection, transconjuctival/scleral bipolar cauterization was applied at the injection site and the presence or absence of leakage or hypotony was studied. Results: At the end of the procedure, no patient showed fluid leakage from the cauterized scleroconjuctival wound. No ocular hypotony of other ophthalmic complications were observed at 1 hour and 1 day from injection and intraocular pressure did not change significantly from baseline at 1 hour and 1 day after injection. Conclusions: Cauterization of the scleral wound after intravitreal dexamethasone implant injection in vitrectomized eyes is safe and effective to avoid scleral leakage with secondary hypotony, obtaining a watertight wound closure.
Anti-vascular endothelial growth factor for unilateral acute idiopathic maculopathy
Authors: Mylonas Georgios , Prager Franz , Wetzel Barbara , Malamos Panagiotis , Deak Gabor , Amon Michael 
Published: November 2017

Purpose: To describe a case of unilateral acute idiopathic maculopathy (UAIM) response to intravitreal therapy with aflibercept (Eylea). Methods: Retrospective case report. Results: A 36-year-old woman with sudden visual impairment and central scotoma was found to have a UAIM in her left eye. Three weeks after continuous worsening of her visual acuity and central scotoma, the patient was treated with intravitreal injections of aflibercept. The visual acuity increased and the macula lesion regressed, causing macula scarring after 2 injections. Conclusions: Intravitreal injections of aflibercept could be a therapy option in patients with UAIM without signs of spontaneous resolution of the clinical manifestations and visual improvement.
Adult Stem Cells in the Pathogenesis and Treatment of Endometriosis
Authors: Cousins Fiona L. , Xiao Li , Gargett Caroline E. 
Published: November 2017

The human endometrium is a dynamic tissue that undergoes approximately 400 cyclical episodes of proliferation, differentiation, shedding, and regeneration in a woman's reproductive lifespan. The regenerative capacity of human endometrium is likely mediated by adult stem cells. At the cellular level, endometrial mesenchymal stem/stromal cells, located in both the functionalis and basalis layers, support regeneration of the stromal vascular compartment and epithelial progenitor cells, postulated to reside in the basalis epithelium, likely regenerate the glands. Bone marrow adult stem cells, including endothelial progenitor cells, may also participate. Endometriosis can be considered an endometrial proliferative disorder due to dysregulation of the cellular and molecular regenerative processes. Endometriosis is primarily thought to occur via retrograde menstruation of endometrial debris. It is postulated that endometrial stem/progenitor cells, which have been identified in menstrual blood, are shed into the peritoneal cavity where they adhere to pelvic organs and initiate endometriotic lesions. The homing of bone-marrow-derived adult stem cells to endometriotic lesions is thought to drive progression of the disease. New drug therapies are urgently required for the treatment of endometriosis due to frequent disease recurrence with current surgical or medical treatments. Medications directly targeting endometrial stem/progenitor cells during menstruation, or following surgery, or targeting bone marrow cell trafficking, are potential targets for future therapies to manage disease initiation and progression. In this review, we will summarize the current literature on adult stem cell contributions to the development of endometriosis and will then examine the current potential therapies that may target endometrial stem/progenitor cells.
Daniels v. Canada: Origins, Intentions, Futures
Authors: Magnet Joseph 
Published: November 2017

On August 14, 2016, the Supreme Court of Canada decided Daniels v. Canada,[1] one of (if not) the most transformative indigenous constitutional cases of this generation. The Daniels decision is the culmination of a 17-year legal odyssey that began in 1999. I’m going to discuss the origins of the Daniels case, the hopes that motivated the plaintiffs’ team I led as we soldiered on, and invite you to peer into some possible futures in the aftermath of our victory.[1] Daniels v. Canada, 2016 SCC 12
Assessment of fine-scale resource selection and spatially explicit habitat suitability modelling for a re-introduced tiger (Panthera tigris) population in central India
Authors: Sarkar Mriganka Shekhar , Krishnamurthy Ramesh , Johnson Jeyaraj A. , Sen Subharanjan , Saha Goutam Kumar 
Published: November 2017

Background
Large carnivores influence ecosystem functions at various scales. Thus, their local extinction is not only a species-specific conservation concern, but also reflects on the overall habitat quality and ecosystem value. Species-habitat relationships at fine scale reflect the individuals’ ability to procure resources and negotiate intraspecific competition. Such fine scale habitat choices are more pronounced in large carnivores such as tiger (Panthera tigris), which exhibits competitive exclusion in habitat and mate selection strategies. Although landscape level policies and conservation strategies are increasingly promoted for tiger conservation, specific management interventions require knowledge of the habitat correlates at fine scale.

Methods
We studied nine radio-collared individuals of a successfully reintroduced tiger population in Panna Tiger Reserve, central India, focussing on the species-habitat relationship at fine scales. With 16 eco-geographical variables, we performed Manly’s selection ratio and K-select analyses to define population-level and individual-level variation in resource selection, respectively. We analysed the data obtained during the exploratory period of six tigers and during the settled period of eight tigers separately, and compared the consequent results. We further used the settled period characteristics to model and map habitat suitability based on the Mahalanobis D2 method and the Boyce index.

Results
There was a clear difference in habitat selection by tigers between the exploratory and the settled period. During the exploratory period, tigers selected dense canopy and bamboo forests, but also spent time near villages and relocated village sites. However, settled tigers predominantly selected bamboo forests in complex terrain, riverine forests and teak-mixed forest, and totally avoided human settlements and agriculture areas. There were individual variations in habitat selection between exploratory and settled periods. Based on threshold limits of habitat selection by the Boyce Index, we established that 83% of core and 47% of buffer areas are now suitable habitats for tiger in this reserve.

Discussion
Tiger management often focuses on large-scale measures, but this study for the first time highlights the behaviour and fine-scale individual-specific habitat selection strategies. Such knowledge is vital for management of critical tiger habitats and specifically for the success of reintroduction programs. Our spatially explicit habitat suitability map provides a baseline for conservation planning and optimizing carrying capacity of the tiger population in this reserve.
Critical Nucleation Length for Accelerating Frictional Slip
Authors: Aldam Michael , Weikamp Marc , Spatschek Robert , Brener Efim A. , Bouchbinder Eran 
Published: November 2017

AbstractThe spontaneous nucleation of accelerating slip along slowly driven frictional interfaces is central to a broad range of geophysical, physical, and engineering systems, with particularly far‐reaching implications for earthquake physics. A common approach to this problem associates nucleation with an instability of an expanding creep patch upon surpassing a critical length Lc. The critical nucleation length Lc is conventionally obtained from a spring‐block linear stability analysis extended to interfaces separating elastically deformable bodies using model‐dependent fracture mechanics estimates. We propose an alternative approach in which the critical nucleation length is obtained from a related linear stability analysis of homogeneous sliding along interfaces separating elastically deformable bodies. For elastically identical half‐spaces and rate‐and‐state friction, the two approaches are shown to yield Lc that features the same scaling structure, but with substantially different numerical prefactors, resulting in a significantly larger Lc in our approach. The proposed approach is also shown to be naturally applicable to finite‐size systems and bimaterial interfaces, for which various analytic results are derived. To quantitatively test the proposed approach, we performed inertial Finite‐Element‐Method calculations for a finite‐size two‐dimensional elastically deformable body in rate‐and‐state frictional contact with a rigid body under sideway loading. We show that the theoretically predicted Lc and its finite‐size dependence are in reasonably good quantitative agreement with the full numerical solutions, lending support to the proposed approach. These results offer a theoretical framework for predicting rapid slip nucleation along frictional interfaces.
Asymmetric Space Weathering on Lunar Crater Walls
Authors: Sim Chae Kyung , Kim Sungsoo S. , Lucey Paul G. , Garrick‐Bethell Ian , Choi Young‐Jun 
Published: November 2017

AbstractUsing new topography‐corrected spectral data from the SELENE spacecraft, here we report a new lunar crater property produced by space weathering. We find that the optical properties of north, south, east, and west walls vary systematically across the Moon; pole‐facing walls are brighter and less red (i.e., less mature) than their equator‐facing counterparts as latitude increases, which we explain by reduced solar wind flux in pole‐facing slopes. On the nearside, we find that east‐west differences in crater wall brightness and redness vary with longitude, which we explain by solar wind shielding as the Moon passes through the Earth's magnetosphere. Because micrometeoroids are largely unaffected by magnetosphere passage, the longitudinal effect is used to discriminate between micrometeoroid and solar wind effects. Thus, for the first time we quantify how surface optical properties vary with solar wind flux.
High‐Altitude Closed Magnetic Loops at Mars Observed by MAVEN
Authors: Xu Shaosui , Mitchell David , Luhmann Janet , Ma Yingjuan , Fang Xiaohua , Harada Yuki , Hara Takuya , Brain David , Weber Tristan , Mazelle Christian , DiBraccio Gina A. 
Published: November 2017

AbstractWith electron and magnetic field data obtained by the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, we have identified closed magnetic field lines, with both foot points embedded in the dayside ionosphere, extending up to 6,200 km altitude into the Martian tail. This topology is deduced from photoelectrons produced in the dayside ionosphere being observed traveling both parallel and antiparallel to the magnetic field. At trapped‐zone pitch angles (within a range centered on 90° where electrons magnetically reflect before interacting with the atmosphere), cases with either solar wind electrons or photoelectrons have been found, indicating different formation mechanisms for these closed loops. These large closed loops are present in MHD simulations. The case with field‐aligned photoelectrons mixed with solar wind electrons having trapped‐zone pitch angles is likely to be associated with reconnection, while the case with photoelectrons at all pitch angles is probably due to closed field lines being pulled tailward by the surrounding plasma flow. By utilizing an algorithm for distinguishing photoelectrons from solar wind electrons in pitch angle‐resolved energy spectra, we systematically map the spatial distribution and occurrence rate of these closed magnetic loops over the region sampled by the MAVEN orbit. We find that the occurrence rate ranges from a few percent to a few tens of percent outside of the optical shadow and less than one percent within the shadow. These observations can be used to investigate the general magnetic topology in the tail, which is relevant to cold ion escape, reconnection, and flux ropes.
Earthquakes in the Mantle? Insights From Rock Magnetism of Pseudotachylytes
Authors: Ferré Eric C. , Meado Andrea L. , Geissman John W. , Di Toro Giulio , Spagnuolo Elena , Ueda Tadamasa , Ashwal Lewis D. , Deseta Natalie , Andersen Torgeir B. , Filiberto Justin , Conder James A. 
Published: November 2017

AbstractUltramafic pseudotachylytes have been regarded as earthquake fossils formed at mantle depths (i.e., >30 km). Here we show that pseudotachylytes hosted by ultramafic rocks from three localities have distinct magnetic properties. Fresh host peridotites contain only small amounts of coarse‐grained magnetite. In contrast, the ultramafic pseudotachylytes contain variable amounts of significantly finer magnetite that formed coseismically through melting. Among each locality, magnetite abundance in the pseudotachylytes ranges over several orders of magnitude (4–2,000 ppm), and magnetic grain size varies considerably (from single domain to multidomain). Because the host peridotites are compositionally similar, the pseudotachylyte magnetic properties are interpreted to primarily reflect the physical and cooling conditions prevailing during seismic slip. Further, the examination of laboratory‐produced ultramafic pseudotachylytes shows that quenching does not produce superfine magnetite. We hypothesize that the magnetic properties of ultramafic pseudotachylytes are controlled by fO2 and in consequence vary systematically with depth of formation. Therefore, these properties can be used to assess if the ruptures producing the earthquakes that these pseudotachylytes represent nucleated at actual mantle depths or at shallow depths during exhumation of mantle rocks.
Quantification and comparison the dosimetric impact of two treatment couch model in VMAT
Authors: Zhang Ruohui , Gao Yulan , Bai Wenwen 
Published: November 2017

AbstractThe use of Monte Carlo treatment planning systems (TPS) in radiation therapy has increased the dosimetric accuracy of VMAT treatment sequences. However, this accuracy is compromised by not including the treatment couch into the treatment planning process. Therefore, the impact of the treatment couch on radiation delivery output was determined, and two different couch models (uniform couch model A vs two components model B) were included and tested in the Monaco TPS to investigate which model can better quantify the couch influence on radiation dose. Relative attenuation measurements were performed following procedures outlined by TG‐176 with three phantom positions for A–B direction: on the left half (L), in the center (C) and on the right half (R) of the couch. As well as absolute dose comparison of static fields of 10 × 10 cm2 that were delivered through the couch tops with that calculated in the TPS with the couch model at 2 mm and 5 mm computing grid size respectively. The most severe percentage deviation was 4.60% for the phantom positioned at the left half of the couch with 5 mm grid size at gantry angle 120°. The couch model was included in the TPS with a uniform ED of 0.26 g/cm3 or a two component model with a fiber 0.52 g/cm3 and foam core 0.1 g/cm3. After including the treatment couch, the maximum mean dose attenuation was reduced from 3.68% without couch included to (0.60, 0.83, 0.72, and 1.02) % for model A and model B at 2 and 5 mm voxel grid size. The results obtained showed that Model A performed better than the model B, demonstrating lower deviations from measurements and better robustness against dose grid resolution changes. Considering the results of this study, we propose the systematic introduction of the couch Model A in clinical routine. All the reported findings are valid for the Elekta iBEAM® evo Extension 415 couch and these methods can also be used for other couch model.
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy
Authors: Chandrasekaran Krish , Muragundla Anjaneyulu , Demarest Tyler G. , Choi Joungil , Sagi Avinash R. , Najimi Neda , Kumar Pranith , Singh Anmol , Ho Cheng‐Ying , Fiskum Gary , Koch Lauren G. , Britton Steven L. , Russell James W. 
Published: November 2017

AbstractObjectivesThere is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist prevented or treated experimental diabetic peripheral neuropathy (DPN) through glutamate recycling and improved mitochondrial function.MethodsAdult male streptozotocin treated Sprague‐Dawley rats with features of type 1 diabetes mellitus (T1DM) or Low Capacity Running (LCR) rats with insulin resistance or glucose intolerance were treated with 3 or 10 mg/kg/day LY379268. Neuropathy end points included mechanical allodynia, nerve conduction velocities (NCV), and intraepidermal nerve fiber density (IENFD). Markers of oxidative stress, antioxidant response, glutamate recycling pathways, and mitochondrial oxidative phosphorylation (OXPHOS) associated proteins were measured in dorsal root ganglia (DRG).ResultsIn diabetic rats, NCV and IENFD were decreased. Diabetic rats treated with an mGluR2/3 agonist did not develop neuropathy despite remaining diabetic. Diabetic DRG showed increased levels of oxidized proteins, decreased levels of glutathione, decreased levels of mitochondrial DNA (mtDNA) and OXPHOS proteins. In addition, there was a 20‐fold increase in levels of glial fibrillary acidic protein (GFAP) and the levels of glutamine synthetase and glutamate transporter proteins were decreased. When treated with a specific mGluR2/3 agonist, levels of glutathione, GFAP and oxidized proteins were normalized and levels of superoxide dismutase 2 (SOD2), SIRT1, PGC‐1α, TFAM, glutamate transporter proteins, and glutamine synthetase were increased in DRG neurons.InterpretationActivation of glutamate recycling pathways protects diabetic DRG and this is associated with activation of the SIRT1‐PGC‐1α–TFAM axis and preservation of mitochondrial OXPHOS function.