bluuebunny/crossref_metadata_2025_split huggingface dataset:
HD 222237 b: a long-period super-Jupiter around a nearby star revealed by radial-velocity and Hipparcos–Gaia astrometry
Authors: Xiao Guang-Yao , Feng Fabo , Shectman Stephen A , Tinney C G , Teske Johanna K , Carter B D , Jones H R A , Wittenmyer Robert A , Díaz Matías R , Crane Jeffrey D , Wang Sharon X , Bailey J , O’Toole S J , Feinstein Adina D , Rice Malena , Essack Zahra , Montet Benjamin T , Shporer Avi , Butler R Paul 
Published: September 2024

ABSTRACT
Giant planets on long-period orbits around the nearest stars are among the easiest to directly image. Unfortunately these planets are difficult to fully constrain by indirect methods, e.g. transit and radial velocity (RV). In this study, we present the discovery of a super-Jupiter, HD 222237 b, orbiting a star located $11.445\pm 0.002$ pc away. By combining RV data, Hipparcos, and multi-epoch Gaia astrometry, we estimate the planetary mass to be ${5.19}_{-0.58}^{+0.58}\, M_{\rm Jup}$, with an eccentricity of ${0.56}_{-0.03}^{+0.03}$ and a period of ${40.8}_{-4.5}^{+5.8}$ yr, making HD 222237 b a promising target for imaging using the Mid-Infrared Instrument (MIRI) of JWST. A comparative analysis suggests that our method can break the inclination degeneracy and thus differentiate between prograde and retrograde orbits of a companion. We further find that the inferred contrast ratio between the planet and the host star in the F1550C filter ($15.50\, \mu \rm m$) is approximately $1.9\times 10^{-4}$, which is comparable with the measured limit of the MIRI coronagraphs. The relatively low metallicity of the host star ($\rm -0.32\, dex$) combined with the unique orbital architecture of this system presents an excellent opportunity to probe the planet–metallicity correlation and the formation scenarios of giant planets.
‘The Course Least Likely to Attract Sceptical Officialdom’: Archiving The Battle of Maldon and the Poetry and Boats of Bill Griffiths
Authors: Kears Carl 
Published: September 2024

Abstract
Bill Griffiths (1948–2007) was a poet, publisher, activist and researcher of languages and local history whose creative and scholarly practices frequently drew on the early medieval past. As an early ‘creative critic’, Griffiths is an important case study for an examination of how Old English studies has developed in its attitudes towards research that takes place without, but encounters, the academy. This article focuses on Griffiths’ edition and translation of The Battle of Maldon (1991). Griffiths published many translations of Old English prose and poetry, but his Maldon is a key text because it was one of only a few works by Griffiths to be reviewed in an academic journal. That review, by Donald Scragg, was not favourable, but it did inspire Griffiths to enter a new period of creative medieval work. By examining Griffiths’ medievalist writings from the time of his Maldon, this article reveals that Griffiths’ relationship with that Old English poem was motivated by his investment in Essex and the North Sea coast as a poet and bookmaker. At the time he was working on his Maldon, Griffiths not only ‘sailed’ a boat from London to the Thames estuary but lost another houseboat in an accidental fire that destroyed many of his papers. These events would also shape his edition and translation of the Old English poem. A reappraisal of Griffiths’ works now can mark a turn towards reassessing the place of contemporary poetry and non-institutional research in the histories of Old English poems and their editions.
Sleep induced by mechanosensory stimulation provides cognitive and health benefits in Drosophila
Authors: Inami Sho , Koh Kyunghee 
Published: September 2024

Abstract

Study Objectives
Sleep is a complex phenomenon regulated by various factors, including sensory input. Anecdotal observations have suggested that gentle rocking helps babies fall asleep, and experimental studies have verified that rocking promotes sleep in both humans and mice. Recent studies have expanded this understanding, demonstrating that gentle vibration also induces sleep in Drosophila. Natural sleep serves multiple functions, including learning and memory, synaptic downscaling, and reduction of harmful substances associated with neurodegenerative diseases. Here, we investigated whether vibration-induced sleep (VIS) provides similar cognitive and health benefits in Drosophila.

Methods
We administered gentle vibration to flies that slept very little due to a forced activation of wake-promoting neurons and investigated how the vibration influenced learning and memory in the courtship conditioning paradigm. Additionally, we examined the effects of VIS on synaptic downscaling by counting synaptic varicosities of select neurons. Finally, we determined whether vibration could induce sleep in Drosophila models of Alzheimer’s disease (AD) and suppress the accumulation of Amyloid β (Aβ) and Tubulin Associated Unit (TAU).

Results
VIS enhanced performance in a courtship conditioning paradigm and reduced the number of synaptic varicosities in select neurons. Moreover, vibration improved sleep in Drosophila models of AD, reducing Aβ and TAU levels.

Conclusions
Mechanosensory stimulation offers a promising noninvasive avenue for enhancing sleep, potentially providing associated cognitive and health benefits.
Diospyros kaki fruit aqueous extract individual/combined with famotidine mitigates peptic ulcer induced by alcohol in rats
Authors: Dhawefi Nourhène , Jedidi Saber , Sammari Houcem , Ayari Ala , Jridi Mourad , Sebai Hichem 
Published: September 2024

Abstract
The present study was performed to evaluate the therapeutic impact of Diospyros kaki fruit aqueous extract (DKFAE) on ethanol induced peptic ulcer. The phytochemical studies of DKFAE were investigated using colorometric analysis. Gastric ulcer was induced by one dose of ethanol (5 ml/Kg, b.w) on 24 h empty stomach. Then, the plant extract (200, 400 mg/kg) was orally administrated for 2 weeks. Famotidine (FAM: 40 mg/kg, b.w.): a reference drug was also tested. The effect of mixture dose between the fruit extract and FAM (DKFAE, 50 mg/kg PC, p.o. + FAM, 50 mg/kg PC, p.o.) was also evaluated. One hour after induction of ulcer blood samples were collected, stomach acidity and volume, as well as lesion counts were measured, then stomach and intestine of scarified rats were subjected to biochemical, macroscopic and microscopic studies. Results showed that DKFAE exhibited an important antioxidant potential. In vivo, the results showed that alcohol induced gastric damage, improving oxidative stress markers level such as MDA and H2O2, gastric and intestinal calcium and free iron. The intoxication by ethanol also produce an inflammation occurred by high level of the C-reactive protein (CRP) and alkaline phosphatase (ALP) activity in plasma. In contrast, DKFAE and the mixture dose significantly protect against macroscopic and histological injuries, the secretory profile disturbances, lipid peroxidation, antioxidant enzymes activities and non enzymatic antioxidant level decrease induced by ethanol administration. More impressively, the mixture dose exerted the more excellent effect than DKFAE and famotidine each alone showing is possible synergism.
Improving Benefit and Reducing Burden of Informal Caregiving for Patients With Heart Failure
Authors: Doyon Katherine , Flint Kelsey , Albright Karen , Bekelman David 
Published: September 2024

Background
Few randomized clinical trials test the effect of interventions on heart failure caregiver well-being.

Objective
The aim of this study was to determine the effect of a patient-focused symptom and psychosocial collaborative care intervention (Collaborative Care to Alleviate Symptoms and Adjust to Illness) on heart failure caregiver depression, burden, and benefit-finding.

Methods
A sequential explanatory mixed-method design was used in the context of a multisite, randomized clinical trial. Self-reported caregiver depression, burden, and benefit-finding were assessed at baseline and 12 months. Thematic analysis was conducted on social worker documentation of a psychosocial intervention with caregivers.

Results
One hundred one caregivers were randomized to usual care or Collaborative Care to Alleviate Symptoms and Adjust to Illness. There were no significant differences in caregiver depression, burden, or benefit-finding between usual care and Collaborative Care to Alleviate Symptoms and Adjust to Illness. Caregiver outcomes were discussed in 42% of intervention notes, highlighting varied and complex caregiver experiences. Inductive analysis reaffirmed the complexity and range of caregiver needs and experiences.

Conclusion
A patient symptom/psychosocial intervention did not impact caregiver well-being. Interventions should target specific needs of caregivers.
Pain During Incarceration
Authors: MacLennan Duncan Stewart , Lasiuk Gerri , Kunyk Diane , Mayan Maria 
Published: September 2024

ABSTRACTIntroductionHypermasculine prison culture produces hierarchies based on individuals’ ability to assert dominance through strength and violence. Pain can impact physical strength, thereby limiting the ability to elevate or maintain social status within such hierarchies.AimThe aim of the study was to explore the pain experiences of incarcerated men who were embedded into hypermasculine prison culture.MethodsInterpretive description co-positioned with relational ethics informed the study design. Twelve males participated in 1-hour interviews, which were transcribed verbatim and analyzed inductively to identify themes. The data analysis occurred in three phases: sorting and organizing, making sense of patterns, and transforming patterns into findings.ResultsWe found that correctional settings were characterized by a social culture of toxic hypermasculinity that influenced the pain experiences of people who were incarcerated. Individuals who experienced pain were more vulnerable to self-isolation in situations in which pain threatened their ability to defend themselves and their previously established social status within the prison hierarchy. Yet, those who felt secure in subordinate hierarchical positions and had effective peer relationships perceived greater safety in communal settings, which proved to be a distraction from pain.ConclusionIn the context of incarceration, positive peer relationships and perceptions of safety positively influenced individuals’ experience of pain.
The global status of nursing research on hemodialysis: A bibliometric and visualized analysis
Authors: Wang Yufen , Yang Luhuan , Lei Yunhong 
Published: September 2024

Background:
Hemodialysis (HD)-related nursing research has been growing over the past 2 decades, providing critical insights into improving patient care and outcomes. This study aimed to visualize the hotspots and emerging frontiers in HD-related nursing research, offering valuable references for future studies.

Methods:
A bibliometric analysis was conducted on publications related to HD nursing research from the Web of Science Core Collection database, spanning the years 2002 to 2023, and the characteristics of literature such as authors, co-cited authors, countries, research institutions, journal distribution, keywords, and cited literature were visually analyzed using CiteSpace and VOSviewer.

Results:
A total of 1019 publications were included in this study. The major contributors to this field were the United States, China, and Australia. The University of Sao Paulo emerged as the most prolific institution. The principal contributors were the Nephrology Nursing Journal, followed by Journal of Renal Care and Journal of Clinical Nursing. The top 5 co-occurrence keywords included HD, quality of life, dialysis, chronic kidney disease, and end-stage renal disease. The burst detection of keywords showed that current research frontier trends were pain and validation. The top 5 largest clusters of cited references included research on systematic review research, nurse-led disease management program, family caregiver, end-stage renal disease, and self-care intervention.

Conclusion:
This study reveals productive authors, countries and institutions, research hotspots, and trends of HD-related nursing research over the past 2 decades, offering a comprehensive overview of this field worldwide.
The influence of COVID-19 on short-term mortality in acute ischemic stroke: A systematic review and meta-analysis
Authors: Xue Yi-dong , Zheng Ying-ying , Cao Chan , Shi Qiang 
Published: September 2024

Objective:
To evaluate the differences in short-term mortality risk between acute ischemic stroke (AIS) patients with and without SARS-CoV-2 infection.

Methods:
PubMed, EMBASE, Scopus, and Cochrane Databases were systematically searched from December 1, 2019 to May 20, 2022 using the keywords coronavirus disease 2019 (COVID-19), COVID-19, SARS-CoV-2, and ischemic stroke. A random-effects model was estimated, and subgroup analysis and meta-regressions were performed. The quality of eligible studies was assessed using the Newcastle-Ottawa Scale.

Results:
A total of 26 eligible studies with 307,800 patients were included in this meta-analysis. The overall results show that in-hospital and 90-day mortality was 3.31-fold higher in AIS with SARS-CoV-2 patients compared with those without SARS-CoV-2. When matched for age and National Institutes of Health Stroke Scale score at admission, the risk ratio of in-hospital mortality from AIS among patients with SARS-CoV-2 versus without decreased to 2.83. Reperfusion therapy and endovascular thrombectomy may further reduce the risk of death in patients to some extent but do not increase the incidence of symptomatic intracerebral hemorrhage. Meta-regression showed that in-hospital mortality decreased with increasing National Institutes of Health Stroke Scale score in AIS with SARS-CoV-2 compared to those without SARS-CoV-2 and that the difference in mortality risk between the 2 was independent of age and sex.

Conclusions:
The results of this study suggest that AIS patients with SARS-CoV-2 have higher short-term mortality compared to AIS patients without SARS-CoV-2, and reperfusion and endovascular thrombectomy therapy may reduce the risk of short-term mortality to some extent. The differences in in-hospital mortality risk were similar across ages and sexes. Focused attention is therefore needed on AIS patients with SARS-CoV-2 to control mortality.
Non-Descemet stripping endothelial keratoplasty for bullous keratopathy in patients with atopic dermatitis: A long-term case report
Authors: Sakakura Saki , Yamazaki Risa , Uchino Yuichi , Negishi Kazuno , Shimmura Shigeto 
Published: September 2024

Rationale:
Patients with atopic dermatitis undergoing penetrating keratoplasty (PKP) face a high risk of postoperative complications. Endothelial keratoplasty may be a safer alternative for such patients, including those with abnormal anterior chamber anatomy.

Patient concerns:
3 male patients, aged 33 to 44, presented with blurred vision at Keio University Hospital.

Diagnosis:
Bullous keratopathy was diagnosed through slit-lamp examination and specular microscopy. Two patients had well-controlled systemic atopic dermatitis, while 1 had blepharitis associated with atopic dermatitis. Two patients had peripheral anterior synechia, and 2 had undergone glaucoma surgery before keratoplasty.

Interventions:
Non-Descemet stripping endothelial keratoplasty (nDSAEK) was performed by a single surgeon.

Outcomes:
The best-corrected visual acuity ranged from 0.7 to 1.5 logMAR before surgery and from 0.2 to 2.3 logMAR after surgery. One year post-surgery, the graft remained clear in 2 cases; however, in the case of repeated glaucoma surgeries after nDSAEK, the graft became edematous. Corneal endothelial cell density was 1586 and 1988 cells/mm² in 2 cases and undetectable in the failed case. The follow-up period ranged from 2.5 to 9 years.

Lessons:
Despite the presence of peripheral anterior synechia or prior glaucoma surgery, some patients experienced a favorable long-term postoperative course following nDSAEK. This procedure may offer a safer alternative for treating patients with atopic dermatitis who have ocular complications that present a high risk for PKP.
GLP-1 receptor agonist–induced diabetic ketoacidosis: A case report
Authors: Zhang Jiaming , Ma Ying , Zu Qianhe , Wang Xiaohui , Zhang Yao 
Published: September 2024

Rationale:
Glucagon-like peptide-1 is an endogenous incretin that plays an active role in weight loss and hypoglycemia. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA), which has been approved for the treatment of patients with type 2 diabetes (T2D). GLP-1RAs can increase insulin secretion and inhibit glucagon release, thereby leading to a decrease in blood glucose levels within the body. Specifically, GLP-1RAs control postprandial blood glucose levels by inhibiting hepatic glucose production and delaying gastric emptying. However, attention should be given to gastrointestinal adverse reactions. There are currently a few cases of GLP-1RA causing diabetic ketoacidosis (DKA).

Patient concerns:
The following report details the case of a 50-year-old Chinese female who has been living with diabetes for 12 years. Initially diagnosed with T2D, she was subsequently identified as a patient with latent autoimmune diabetes in adults (LADA) following treatment. The patient presented severe nausea, vomiting, and fatigue 1 day after injecting dulaglutide 1 time and discontinuing insulin therapy. She was diagnosed with severe DKA in the emergency department.

Diagnoses:
LADA and DKA.

Interventions:
Changed from dulaglutide to insulin therapy.

Outcomes:
After discontinuing dulaglutide and switching to insulin for blood glucose reduction, the patient’s DKA was corrected, and blood glucose levels returned to normal.

Lessons:
This case suggests that clinicians should be alert to patients with severe DKA in cases of severe gastrointestinal adverse reactions after the use of GLP-1RAs. In addition, in most countries, GLP-1RAs are administered to patients with T2D, but we should consider the use of GLP-1RAs in patients with type 1 diabetes and LADA.
Acute respiratory distress syndrome as the initial symptom of hepatic angiosarcoma with Kasabach–Merritt syndrome: A case report
Authors: Cui Xiaoqian , Zhang Min , Song Debiao , Tian Jiakun 
Published: September 2024

Rationale:
Hepatic angiosarcoma (HSA) has a poor prognosis. Our understanding of its clinical features, diagnosis, treatment, and prognosis remains limited. In certain cases, vascular tumors such as HSA can induce bleeding complications due to thrombocytopenia, known as Kasabach–Merritt syndrome (KMS). When KMS symptoms occur in the lungs, its clinical manifestations closely resemble those of ARDS, leading to misdiagnosis and poor outcomes. Unfortunately, this condition is extremely rare and there is a lack of relevant case reports, which further adds to the difficulty of its diagnosis and treatment.

Patient concerns:
This case report describes a patient who initially presented with symptoms of ARDS. Due to the unique nature of these symptoms, the patient underwent a complex diagnostic and treatment process before finally being diagnosed with HSA complicated by KMS through pathological examination.

Diagnoses:
The patient was eventually diagnosed with HSA by pathology and KMS with multiorgan hemorrhage.

Interventions:
Highly misleading clinical manifestations were recorded during the diagnosis and treatment, which, to our knowledge, have not been previously reported.

Outcomes:
The patient died from a massive pulmonary hemorrhage.

Lessons:
Dysfunction of a single organ or system may be the external manifestation of a multi-system clinical disease. Therefore, in the clinical diagnosis and treatment process, especially during early diagnosis, while it is important to focus on the primary or typical clinical symptoms, it is equally crucial not to underestimate or ignore accompanying symptoms that lack specificity. When diagnosis and treatment reach an impasse, these “atypical” symptoms often prove to be key in solving the puzzle.
Enhancing early-stage healing responses through the modified “Poncho” technique in customized titanium mesh–mediated bone regeneration: A soft tissue management approach—case series
Authors: Wang Siwei , De Santis Daniele 
Published: September 2024

Rationale:
Soft tissue management is critical in bone augmentation surgery to prevent wound dehiscence. Several strategies for passive tissue primary closure have been explored. This article introduces a flap design known as the modified “Poncho” technique (MPT), integrated with customized titanium mesh–mediated bone regeneration, and investigates the healing quality during the initial stages of an incision.

Patient concerns:
The cohort consisted of 5 patients undergoing customized bone regeneration procedures, concerned primarily with the successful integration and healing of the augmented bone site without complications such as wound dehiscence or infection.

Diagnosis:
All patients were diagnosed with insufficient bone volume requiring augmentation to support future dental implants, necessitating the use of customized titanium mesh for guided bone regeneration.

Interventions:
The MPT was detailed and applied during the customized bone regeneration procedures. Postoperative evaluations included recording complications and using Landry’s healing index at intervals of 3, 7, 14, and 30 days post-surgery to assess the technique’s performance in early wound closure.

Outcomes:
The study found that 95.7% of surgery sites experienced uneventful soft tissue healing within the observation period. Only 1 of 23 sites exhibited partial wound dehiscence at postsurgical days 14 and 30, accompanied by mild inflammation. The Landry’s healing index increased from 3 ± 0.47 to a final value of 4.69 ± 1.06, indicating substantial improvement in healing over time.

Lessons:
The MPT shows promise as an innovative approach for promoting passive and predictable primary wound closure beneath a digitally customized titanium mesh for bone regeneration, demonstrating a high rate of successful healing and minimal complications during the early postoperative phase.