bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case–control study
Authors: Takeshita Yoshihide , Shibata Nobuto , Kasanuki Koji , Nagata Tomoyuki , Shinagawa Shunichiro , Kobayashi Nobuyuki , Ohnuma Tohru , Suzuki Ayako , Kawai Eri , Takayama Toshiki , Nishioka Kenya , Motoi Yumiko , Hattori Nobutaka , Nakayama Kazuhiko , Yamada Hisashi , Arai Heii 
Published: October 2016

Background/AimsInteraction of receptor for advanced glycation end products (RAGE) with amyloid‐β increases amplification of oxidative stress and plays pathological roles in Alzheimer's disease (AD). Oxidative stress leads to α‐synuclein aggregation and is also a major contributing factor in the pathogenesis of Lewy body dementias (LBDs). Therefore, we aimed to investigate whether RAGE gene polymorphisms were associated with AD and LBDs.MethodsFour single nucleotide polymorphisms (SNPs)—rs1800624, rs1800625, rs184003, and rs2070600—of the gene were analyzed using a case–control study design comprising 288 AD patients, 76 LBDs patients, and 105 age‐matched controls.ResultsLinkage disequilibrium (LD) examination showed strong LD from rs1800624 to rs2070600 on the gene (1.1 kb) in our cases in Japan. Rs184003 was associated with an increased risk of AD. Although there were no statistical associations for the other three SNPs, haplotypic analyses detected genetic associations between AD and the RAGE gene. Although relatively few cases were studied, results from the SNPs showed that they did not modify the risk of developing LBDs in the Japanese population.ConclusionOur findings suggested that polymorphisms in the RAGE gene are involved in genetic susceptibility to AD. Copyright © 2016 John Wiley & Sons, Ltd.
Supratracheal partial laryngectomy with tracheohyoidoepiglottopexy (open partial horizontal laryngectomy type IIIa + cricoarytenoid unit): Surgical technique illustrated in the anatomy laboratory
Authors: Succo Giovanni , Crosetti Erika , Bertolin Andy , Lucioni Marco , Rizzotto Giuseppe 
Published: October 2016

ABSTRACTThe first supratracheal partial laryngectomy (STPL) with tracheohyoidoepiglottopexy was performed in 1972. This procedure entailed preservation of the suprahyoid epiglottis as well as a pexy of the hyoid bone and residual epiglottis to the first tracheal ring; however, this technique was abandoned by the same author in the early 1980s because of poor functional outcomes. © 2016 Wiley Periodicals, Inc. Head Neck 39: 392–398, 2017
Extracapsular dissection versus superficial parotidectomy in benign parotid gland tumors: The Vienna Medical School experience
Authors: Kadletz Lorenz , Grasl Stefan , Grasl Matthäus C. , Perisanidis Christos , Erovic Boban M. 
Published: October 2016

AbstractBackgroundThe purpose of this study was to evaluate the clinical outcome in patients with benign parotid gland tumors after extracapsular dissection or superficial parotidectomy (SP).MethodsEight hundred ninety‐four patients with primary pleomorphic adenoma or Warthin's tumor were included from this study. Type and length of surgery, tumor size, resection margins, and complication rates were assessed.ResultsThree hundred ninety‐five (44.2%) extracapsular dissections and 499 SPs (55.8%) were performed. The rate of positive margins was significantly higher in the extracapsular dissection compared to the SP group (29.4% vs 10.2%; p < .0001). Recurrent disease (extracapsular dissection = 7.2% vs SP = 2.2%; p = .0003) and permanent facial palsy were significantly more frequent after extracapsular dissection than SP (2.2% vs 0.6%; p = .0396). Significant prolonged surgery time was observed after SP (146 vs 94 minutes; p < .0001).ConclusionBecause extracapsular dissection led to a significantly higher percentage of permanent facial palsy, recurrent disease, and positive resection margins compared to SP, we recommend SP for treating benign parotid gland tumors. © 2016 Wiley Periodicals, Inc. Head Neck 39: 356–360, 2017
Circulating Epstein‐Barr virus–encoded micro‐RNAs as potential biomarkers for nasal natural killer/T‐cell lymphoma
Authors: Komabayashi Yuki , Kishibe Kan , Nagato Toshihiro , Ueda Seigo , Takahara Miki , Harabuchi Yasuaki 
Published: October 2016

AbstractNasal natural killer/T‐cell lymphoma (NNKTL) is an Epstein‐Barr virus (EBV)–associated malignancy and is characterized by local invasion and widespread dissemination, with a consequent poor prognosis. Micro‐RNAs (miRNAs) play roles in the pathogenesis of several malignancies by regulating gene expression and have been recently identified as stable entities in serum. Here, we investigated the value of circulating EBV‐miRNAs as biomarkers for NNKTL. Sera of patients with NNKTL were subjected to miRNA polymerase chain reaction (PCR)–array analysis, after which serum EBV‐miRNA levels were verified using quantitative PCR. The latter analysis revealed high miR‐BART2‐5p, miR‐BART7‐3p, miR‐BART13‐3p, and miR‐BART1‐5p expression levels in sera of patients with NNKTL and indicated accurate values for discriminating patients with NNKTL from healthy controls. Levels of these 4 EBV‐miRNAs, which were secreted from NNKTL cells, significantly decreased after treatment compared with those before treatment. Furthermore, a high circulating miR‐BART2‐5p level was associated with disease progression and poor prognosis in patients with NNKTL. Our findings demonstrate that circulating EBV‐miRNAs, particularly miR‐BART2‐5p, may serve as potential diagnostic and prognostic biomarkers in patients with NNKTL.
Bioactive and inert dental glass‐ceramics
Authors: Montazerian Maziar , Zanotto Edgar Dutra 
Published: October 2016

AbstractThe global market for dental materials is predicted to exceed 10 billion dollars by 2020. The main drivers for this growth are easing the workflow of dentists and increasing the comfort of patients. Therefore, remarkable research projects have been conducted and are currently underway to develop improved or new dental materials with enhanced properties or that can be processed using advanced technologies, such as CAD/CAM or 3D printing. Among these materials, zirconia, glass or polymer‐infiltrated ceramics, and glass‐ceramics (GCs) are of great importance. Dental glass‐ceramics are highly attractive because they are easy to process and have outstanding esthetics, translucency, low thermal conductivity, high strength, chemical durability, biocompatibility, wear resistance, and hardness similar to that of natural teeth, and, in certain cases, these materials are bioactive. In this review article, we divide dental GCs into the following two groups: restorative and bioactive. Most restorative dental glass‐ceramics (RDGCs) are inert and biocompatible and are used in the restoration and reconstruction of teeth. Bioactive dental glass‐ceramics (BDGCs) display bone‐bonding ability and stimulate positive biological reactions at the material/tissue interface. BDGCs are suggested for dentin hypersensitivity treatment, implant coating, bone regeneration and periodontal therapy. Throughout this paper, we elaborate on the history, processing, properties and applications of RDGCs and BDGCs. We also report on selected papers that address promising types of dental glass‐ceramics. Finally, we include trends and guidance on relevant open issues and research possibilities. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 619–639, 2017.
Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor
Authors: Delgado-Calle Jesus , Tu Xiaolin , Pacheco-Costa Rafael , McAndrews Kevin , Edwards Rachel , Pellegrini Gretel G , Kuhlenschmidt Kali , Olivos Naomie , Robling Alexander , Peacock Munro , Plotkin Lilian I , Bellido Teresita 
Published: October 2016

ABSTRACT

Osteocytes integrate the responses of bone to mechanical and hormonal stimuli by poorly understood mechanisms. We report here that mice with conditional deletion of the parathyroid hormone (PTH) receptor 1 (Pth1r) in dentin matrix protein 1 (DMP1)-8kb–expressing cells (cKO) exhibit a modest decrease in bone resorption leading to a mild increase in cancellous bone without changes in cortical bone. However, bone resorption in response to endogenous chronic elevation of PTH in growing or adult cKO mice induced by a low calcium diet remained intact, because the increased bone remodeling and bone loss was indistinguishable from that exhibited by control littermates. In contrast, the bone gain and increased bone formation in cancellous and cortical bone induced by daily injections of PTH and the periosteal bone apposition induced by axial ulna loading were markedly reduced in cKO mice compared to controls. Remarkably, however, wild-type (WT) control littermates and transgenic mice overexpressing SOST injected daily with PTH exhibit similar activation of Wnt/β-catenin signaling, increased bone formation, and cancellous and cortical bone gain. Taken together, these findings demonstrate that Pth1r in DMP1-8kb–expressing cells is required to maintain basal levels of bone resorption but is dispensable for the catabolic action of chronic PTH elevation; and it is essential for the anabolic actions of daily PTH injections and mechanical loading. However, downregulation of Sost/sclerostin, previously shown to be required for bone anabolism induced by mechanical loading, is not required for PTH-induced bone gain, showing that other mechanisms downstream of the Pth1r in DMP1-8kb–expressing cells are responsible for the hormonal effect. © 2016 American Society for Bone and Mineral Research.
Association of serum vitamin D with osteosarcopenic obesity: Korea National Health and Nutrition Examination Survey 2008–2010
Authors: Kim Jinhee , Lee Yunhwan , Kye Seunghee , Chung Yoon‐Sok , Lee Okhee 
Published: October 2016

AbstractBackgroundSerum vitamin D levels have been reported to be associated with individual components of body composition. However, the relationship between serum vitamin D and combined indices of adverse body composition is largely unknown. This cross‐sectional study examined the association between serum vitamin D and osteosarcopenic obesity in a nationally representative sample of middle‐aged and older adults.MethodsWe analysed the Korea National Health and Nutrition Examination Surveys (IV and V) conducted in 2008–2010, consisting of 5908 (2485 men, 3423 women) aged ≥ 50 years. Serum vitamin D levels were determined by radioimmunoassay, and body composition was evaluated by dual‐energy x‐ray absorptiometry. The association between serum vitamin D levels and the number of abnormalities in body composition, including osteosarcopenic obesity, a low bone and muscle mass with concurrent high fat mass, was analysed by multinomial logistic regression adjusting for covariates.ResultsIn men, after controlling for covariates, higher vitamin D levels were associated with a significantly reduced likelihood of the number of phenotypes of adverse body composition (P for trend < 0.05). Those in the highest tertile group of serum vitamin D levels, compared with those in the lowest tertile, were less likely to have adverse body composition, numbering one (odds ratio [OR] = 0.67, 95% confidence interval [CI]: 0.49, 0.92), two (OR = 0.49, 95% CI: 0.33, 0.73), and three (osteosarcopenic obesity; OR = 0.42, 95% CI: 0.26, 0.67). In women, those in the highest tertile group of serum vitamin D levels, compared with those in the lowest tertile, were less likely to have osteosarcopenic obesity (OR = 0.55, 95% CI: 0.33, 0.93). Vitamin D deficiency (<20 ng/mL) in men was significantly associated with an increased likelihood of a higher number of adverse body composition, especially for osteosarcopenic obesity (OR = 2.08, 95% CI: 1.42, 3.03). Vitamin D deficient women, compared with those having normal levels of serum vitamin D, were also more likely to demonstrate osteosarcopenic obesity (OR = 1.99, 95% CI: 1.30, 3.05).ConclusionsA high serum vitamin D level in mid‐ and late‐life was associated with reduced odds of multiple adverse body composition, especially osteosarcopenic obesity, suggesting potential health benefits of maintaining adequate levels of vitamin D.
Dendroclimatology and historical climatology of Voronezh region, European Russia, since 1790s
Authors: Matskovsky Vladimir , Dolgova Ekaterina , Lomakin Nikita , Matveev Sergey 
Published: October 2016

ABSTRACTExisting high‐resolution reconstructions of hydroclimate variability in Europe are lacking natural proxy data from European Russia. For this reason, developing new hydroclimate proxies for this vast region is crucial. It is even more important, because drought evidences from the forest‐steppe region of European Russia will elucidate the eastern borders of large‐scale meteorological events that had been covering large parts of Europe in the past. In this study, we provide new tree‐ring chronologies of Pinus sylvestris L. for the site in the southernmost natural pine forest in European Russia. Based on these chronologies, we develop a quantitative drought reconstruction and disclose the driest years in the region since 1790s. The reconstruction of Standardized Precipitation Evapotranspiration Index explains 29–39% of instrumental period variability, it adequately tracks low‐frequency (30–50 years) variations of drought indices as well as extreme events. Collection of historical evidences from periodicals of the 19th century and other historical evidences helped to verify the new reconstruction. Using gridded precipitation reconstruction over Europe, we showed a possible existence of large‐scale hydroclimate events that had occurred in the East European forest‐steppe region in the 19th century. Possible connections of drought events in European Russia with Atlantic Multidecadal Oscillation and Scandinavian teleconnection pattern are discussed. We argue that being a complex natural archive, ring width of pine in Voronezh region can be successfully used as an estimator of prolonged droughts (1–2 years).
The new Israeli feed safety law: challenges in relation to animal and public health
Authors: Barel Shimon , Elad Dani , Cuneah Olga , Shimshoni Jakob A 
Published: October 2016

AbstractThe Israeli feed safety legislation, which came to prominence in the early 1970s, has undergone a major change from simple feed safety and quality regulations to a more holistic concept of control of feed safety and quality throughout the whole feed production chain, from farm to the end user table. In February 2014, a new law was approved by the Israeli parliament, namely the Control of Animal Feed Law, which is expected to enter into effect in 2017. The law is intended to regulate the production and marketing of animal feed, guaranteeing the safety and quality of animal products throughout the production chain. The responsibility on the implementation of the new feed law was moved from the Plant Protection Inspection Service to the Veterinary Services and Animal Health. In preparation for the law's implementation, we have characterized the various sources and production lines of feed for farm and domestic animals in Israel and assessed the current feed safety challenges in terms of potential hazards or undesirable substances. Moreover, the basic requirements for feed safety laboratories, which are mandatory for analyzing and testing for potential contaminants, are summarized for each of the contaminants discussed. © 2016 Society of Chemical Industry
Paper‐based 1‐MCP treatment suppresses cell wall metabolism and delays softening of Huanghua pears during storage
Authors: Chen Yihui , Sun Junzheng , Lin Hetong , Hung Yen‐Con , Zhang Shen , Lin Yifen , Lin Ting 
Published: October 2016

AbstractBACKGROUNDHuanghua pear will lose its firmness quickly during postharvest storage at ambient temperature, and hence has limited storage and marketing potential. In this study, Huanghua pears treated with paper containing 0 (control) or 0.9 μL L−1 1‐methylcyclopropene (1‐MCP) for 12 h, and then stored at (25 ± 1) °C for 30 days, were investigated for the effect on fruit firmness, cell wall composition and activities of cell wall‐degrading enzymes.RESULTSHuanghua pears without 1‐MCP treatment softened rapidly during room‐temperature storage and cell wall composition analyses showed an increase in water‐soluble pectin (WSP) and decreases in cell wall materials (CWM) and cell wall components such as Na2CO3‐soluble pectin (NSP), cellulose and hemicellulose. In contrast, the 1‐MCP‐treated fruits maintained higher firmness than the control; also, the treatment prevented the formation of WSP and reduced the degradation of CWM and cell wall components including NSP, cellulose and hemicellulose. 1‐MCP treatment also significantly lowered the activities of cell wall‐degrading enzymes such as pectinesterase, polygalacturonase, β‐galactosidase and cellulase during storage.CONCLUSION1‐MCP treatment can slow down the softening of Huanghua pears through reducing cell wall‐degrading enzyme activities and hence maintain the integrity of the cell wall structure. © 2016 Society of Chemical Industry
Relationship of the number and size of superficial groin lymph nodes with the stage of secondary lymphatic edema
Authors: Onoda Satoshi , Kimata Yoshihiro , Yamada Kiyoshi , Seki Noriko , Hiramatsu Yuji 
Published: October 2016

PurposeThis study evaluated the relationships of the size and number of superficial groin lymph nodes with the lower limb lymphedema stage and thus examined the role of superficial lymphatic lymph nodes in secondary lymphedema development.MethodsWe determined the number and size of superficial groin lymph nodes using horizontal plane computed tomography (CT) and the lymphedema stage in the lower limbs of 25 patients with gynecologic cancer.ResultsThe patients had an average of 2.92 (range, 1–7) superficial groin lymph nodes; the mean size of the 146 evaluated lymph nodes was 7.55 mm (range, 5–15 mm). In 19 of 25 patients (76%), the side with major edema contained fewer superficial groin lymph nodes. In total, 22 patients (88%) had fewer superficial groin lymph nodes or a smaller total lymph node size on the edematous dominant side.ConclusionsIn this evaluation of the link between superficial groin lymph node laterality and secondary lymphedema staging, we found that patients with large lymph node numbers and sizes tended to present with a relatively earlier stage of lymphedema. Our results therefore suggest that the size and number of superficial groin lymph nodes affect the lymphedema stage. J. Surg. Oncol. 2016;114:940–946. © 2016 Wiley Periodicals, Inc.
Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy‐assisted salivary duct surgery
Authors: Delagnes Elise A. , Aubin‐Pouliot Annick , Zheng Melissa , Chang Jolie L. , Ryan William R. 
Published: October 2016

ObjectivesTo prospectively assess symptoms before and after sialendoscopy‐assisted salivary duct surgery (SASDS) in patients with symptomatic sialadenitis without sialolithiasis.Study DesignProspective cohort study.MethodsPatients with chronic obstructive sialadenitis without sialolithiasis (COSWS) completed the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire prior to SASDS and 3 months postoperatively.ResultsOf 80 consecutive patients in a 20‐month period, 20 surveyed patients underwent SASDS for COSWS in 37 symptomatic glands. Major symptom improvement (> 10 COSS score reduction) was reported in 24 of 37 (65%) of all glands, including 14 of 21 (67%) of radioactive iodine (RAI)‐induced cases and 10 of 13 (77%) of idiopathic sialadenitis cases. A significant reduction in postoperative mean COSS scores was seen overall (12.6 points, standard deviation [SD] 19.3, P < 0.05 to a post‐SASDS mean score of 26.6). However, 19 of 37 (51%) glands demonstrated postoperative COSS scores above 25, denoting persistent disease. Mean COSS score reductions in RAI‐induced sialadenitis (12.4 points, SD 22.7, P < 0.05) and idiopathic sialadenitis (16.3 points, SD 13.7, P < 0.005) groups were significant, with post‐SASDS COSS mean scores of 30.6 (SD 19.8) and 20.8 (SD 13.8), respectively. Ducts with stenoses treated with dilation or sialodochoplasty showed significant COSS improvements of 21.1 (SD 17.9) and 12.4 points (SD 10.7), respectively (P < 0.05). In a multivariate analysis, both the presence of stenosis and sialodochoplasty were independent predictors of complete or partial resolution (post‐COSS score < 25) and major symptom improvement (P < 0.05).ConclusionSASDS provides short‐term symptom reduction in patients with COSWS; particularly in RAI‐induced and idiopathic sialadenitis, and in duct stenosis amenable to dilation or sialodochoplasty. However, approximately half of the glands did not achieve meaningful symptom resolution.Level of Evidence4 Laryngoscope, 127:1073–1079, 2017
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration
Authors: Sanchez‐Contreras Monica , Heckman Michael G. , Tacik Pawel , Diehl Nancy , Brown Patricia H. , Soto‐Ortolaza Alexandra I. , Christopher Elizabeth A. , Walton Ronald L. , Ross Owen A. , Golbe Lawrence I. , Graff‐Radford Neill , Wszolek Zbigniew K. , Dickson Dennis W. , Rademakers Rosa 
Published: October 2016

ABSTRACTBackgroundMutations in the leucine‐rich repeat kinase 2 gene (LRRK2) are the most common genetic cause of Parkinson's disease (PD). Unexpectedly, tau pathology has been reported in a subset of LRRK2 mutation carriers.MethodsTo estimate the frequency of pathogenic LRRK2 mutations and to evaluate the association of common LRRK2 variants with risk of primary tauopathies, we studied 1039 progressive supranuclear palsy (PSP) and 145 corticobasal degeneration patients from the Mayo Clinic Florida brain bank and 1790 controls ascertained at Mayo Clinic. Sanger sequencing of LRRK2 exons 30, 31, 35, and 41 was performed in all patients, and genotyping of all 17 known exonic variants with minor allele frequency >0.5% was performed in patients and controls.ResultsLRRK2 mutational screening identified 2 known pathogenic mutations (p.G2019S and p.R1441C), each in 1 PSP patient, the novel p.A1413T mutation in a PSP patient and the rare p.R1707K mutation in a corticobasal degeneration patient. Both p.A1413T and p.R1707K mutations were predicted damaging by at least 2 of 3 prediction programs and affect evolutionary conserved sites of LRRK2. Association analysis using common LRRK2 variants only showed nominal association of the p.L153L variant with PSP.ConclusionsOur study confirms the presence of pathogenic and potentially pathogenic LRRK2 mutations in pathologically confirmed primary tauopathies, albeit with low frequency. In contrast to PD, common LRRK2 variants do not appear to play a major role in determining PSP and corticobasal degeneration risk. © 2016 International Parkinson and Movement Disorder Society.