bluuebunny/crossref_metadata_2025_split huggingface dataset:
Through the eyes of the parents: a transdiagnostic psychiatric perspective for children with differences of sexual development
Authors: Ozbaran Burcu , Senturk-Pilan Birsen , Yavuz-Kan Oyku , Yulug-Tas Begum , Inal-Kaleli Ipek , Er Eren , Ozen Samim , Goksen Damla , Darcan Sukran 
Published: October 2024

Abstract

Objectives
Existing literature lacks data on a subgroup exhibiting psychiatric symptoms below the DSM-5 diagnostic threshold within differences of sexual development (DSD) cases. Our study aims to assess parental knowledge, attitudes toward DSD, and parental perceptions of emotional and behavioral states through a transdiagnostic perspective.

Methods
The study was conducted with a total of 35 parents of children with DSD. Two groups were established via k-means clustering, based on psychiatric symptomatology levels, derived from The Strength and Difficulties Questionnaire – Parent Form and The Revised Children’s Anxiety and Depression Scale – Parent Form: with one group exhibiting lower reported psychiatric symptoms (LPS=27) and the other demonstrating higher psychiatric symptoms (HPS=8) by parents.

Results
Our study found that many parents were hesitant to disclose DSD diagnoses to their children, believing them to be too young to comprehend the information (42.9 %) and that they were unaware of the available support that could be provided by the medical team in disclosing the diagnosis (25.7 %). Our study found no differences in DSM-5 diagnoses between HPS and LPS groups (p>0.05), with ADHD being the most prevalent diagnosis (21.7 %) and a significant overrepresentation of children with a discrepancy between assigned gender at birth and gender upbringing in the HPS group compared to the LPS group (p<0.001).

Conclusions
Our study emphasizes the necessity of a transdiagnostic approach in psychiatry to move beyond binary conceptualizations and better understand the complexities of individuals with DSD.
The utilization of artificial intelligence in enhancing 3D/4D ultrasound analysis of fetal facial profiles
Authors: Bachnas Muhammad Adrianes , Andonotopo Wiku , Dewantiningrum Julian , Adi Pramono Mochammad Besari , Stanojevic Milan , Kurjak Asim 
Published: October 2024

Abstract
Artificial intelligence (AI) has emerged as a transformative technology in the field of healthcare, offering significant advancements in various medical disciplines, including obstetrics. The integration of artificial intelligence into 3D/4D ultrasound analysis of fetal facial profiles presents numerous benefits. By leveraging machine learning and deep learning algorithms, AI can assist in the accurate and efficient interpretation of complex 3D/4D ultrasound data, enabling healthcare providers to make more informed decisions and deliver better prenatal care. One such innovation that has significantly improved the analysis of fetal facial profiles is the integration of AI in 3D/4D ultrasound imaging. In conclusion, the integration of artificial intelligence in the analysis of 3D/4D ultrasound data for fetal facial profiles offers numerous benefits, including improved accuracy, consistency, and efficiency in prenatal diagnosis and care.
Dynamic nonlocal metasurface for multifunctional integration via phase-change materials
Authors: Yu Shilin , Xu Mingfeng , Pu Mingbo , Tang Xi , Zheng Yuhan , Guo Yinghui , Zhang Fei , Li Xiong , Ma Xiaoliang , Luo Xiangang 
Published: October 2024

Abstract
Non-local metasurface supporting geometric phases at bound states in the continuum (BIC) simultaneously enables sharp spectral resonances and spatial wavefront shaping, thus providing a diversified optical platform for multifunctional devices. However, a static nonlocal metasurface cannot manipulate multiple degrees of freedom (DOFs), making it difficult to achieve multifunctional integration and be applied in different scenarios. Here, we presented and demonstrated phase-change non-local metasurfaces that can realize dynamic manipulation of multiple DOFs including resonant frequency, Q values, band, and spatial wavefront. Accordingly, a metasurface integrating multiple distinct functions is designed, as a proof-of-concept demonstration. Utilizing the geometry phase of quasi-BIC and the tunability of vanadium dioxide (VO2), a dynamic meta-lens is achieved by tailoring spatial light response at quasi-BIC in the temperature range from room temperature to 53 °C. Simultaneously, the sharp Fano resonance of quasi-BIC enables the metasurface to serve as an optical sensor in the mid-infrared band, yielding a sensitivity of 7.96 THz/RIU at room temperature. Furthermore, at the metallic state of VO2 (80 °C), the designed metasurface converts into a mid-infrared broadband absorber, achieving higher than 80 % absorptivity and an average absorption of 90 % from 28.62 THz to 37.56 THz. The proposed metasurface enabling multifunctional performances in different temperatures can effectively improve the availability of devices and find more new and complex scenarios in sensing, imaging, and communications.
Crystal structure of 5,7-dihydroxy-2-phenyl-4H-chromen-4-one–N,N-dimethylformamide(1/1), C18H17NO5
Authors: Jacobs Ayesha , Tangouna Liambo Bissa Marie-Louise 
Published: October 2024

Abstract
C18H17NO5, orthorhombic, P212121 (no. 19), a = 4.6793(9) Å, b = 18.118(4) Å, c = 18.380(4) Å, V = 1,558.2(5) Å3, Z = 4, R

gt
(F) = 0.0448, wR

ref
(F
2) = 0.1246, T = 173(2) K.
Impactos da Leitura Compartilhada no Desenvolvimento Linguístico na Educação Infantil - Revisão Sistemática
Authors: Da Silva Carmen Lucia , Peruzzi Elia da Mota Márcia Maria , Nórte Carlos Eduardo 
Published: October 2024

A leitura compartilhada de livros na primeira infância é importante para o desenvolvimento linguístico das crianças. Entretanto, intervenções que usam a leitura compartilhada para desenvolver a linguagem oral e escrita das crianças têm demonstrado resultados conflitantes. Isso pode ocorrer devido aos diferentes delineamentos das intervenções. O objetivo desta pesquisa foi mapear estudos de intervenção sobre os efeitos da leitura compartilhada de livros de histórias no desenvolvimento linguístico de crianças na Educação Infantil. Para tanto, adotamos as estratégias de Revisão Sistemática da Literatura e seguimos o protocolo Preffered Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Foram realizadas buscas nas bases de dados Eric, Medline, Scielo, Pepsic, Psyc Info e Jstor Journals. Os grupos de palavras-chave que constaram em nossas pesquisas são: (“shared book reading” OR “dialogic reading” OR “Interactive reading” OR “emergent literacy” OR “early literacy”) AND (preschool OR “child education”) AND (reading OR literacy). As etapas de seleção dos estudos foram realizadas por dois revisores independentes. Foram incluídos estudos de intervenção que se concentravam em histórias compartilhadas e desenvolvimento linguístico de crianças de três a seis anos de idade, publicados entre os anos de 2017 e 2022. Foram excluídos estudos que não atendiam aos critérios pré-determinados. A seleção final resultou em 16 artigos que foram analisados para identificar os efeitos da leitura compartilhada no desenvolvimento linguístico das crianças. Os resultados da análise dos estudos selecionados corroboram pesquisas anteriores que oferecem evidências de que a leitura compartilhada de livros contribui positivamente para o desenvolvimento linguístico das crianças.
Serum proteins as predictors of the development of chemotherapy-induced peripheral neuropathy
Authors: Tikhonova O. A. , Druzhininа E. S. , Tuchina O. P. , Druzhinin D. S. , Doktorova S. A. 
Published: October 2024

Background. The development of polyneuropathy in the context of cytotoxic drug administration is a common neurological complication that can significantly impair patients’ quality of life and limit the use of chemotherapy. The difficulties in predicting the manifestations and severity of neurological complications are due to multiple factors, including individual patient characteristics, the type and dosage of the drug used, as well as the presence of comorbid conditions. In recent years, researchers have focused on identifying serum biomarkers that may aid in the early diagnosis and monitoring of Сhemotherapy-induced Peripheral Neuropathy. Understanding their role in the development of polyneuropathy may open new avenues for developing strategies for the prevention and treatment of this complication, which, in turn, could enhance treatment efficacy and improve patients’ quality of life. This review is dedicated to biomarkers and their clinical significance in the development of Сhemotherapy induced Peripheral Neuropathy.Aim. To analyze and summarize the current understanding of serum biological markers of Chemotherapy-induced Peripheral Neuropathy based on literature data.Materials and methods. The literature search was performed using the following databases: PubMed, Medline. Systematic reviews, publications of original studies and meta-analyses between 2000 and 2023 were included in the analysis.Results. Over the past decades, new insights in to the role of biomarkers in the development of Chemotherapy-induced Peripheral Neuropathy have emerged, among which neurofilaments are more specific. The use of readily available and ultra-sensitive techniques for measuring biomarker concentrations will allow early prediction and prevention of this complication.Conclusion. The analysis of literature data has shown the high relevance of the role of biomarkers in the damage of peripheral nervous system structures, which may in the near future affect the management tactics and in turn improve the quality of life of cancer patients.
Analysis of changes in the levels of soluble molecules CD50, CD54 and CD95 in the blood serum of patients with uterine fibroids depending on the characteristics of the disease (pilot study)
Authors: Alyasova A. V. , Mamaeva M. E. , Kubysheva N. I. , Novikov V. V. 
Published: October 2024

Background. Currently, the search for circulating immunological and inflammatory markers that play a significant role in the pathogenesis of uterine fibroids (UF) is relevant.Aim. Changes in the serum levels of soluble molecules CD50 (sCD50), CD54 (sCD54) and CD95 (sCD95) in patients with UF depending on the characteristics of the disease.Materials and methods. The study involved 78 patients with UF aged 31–59 years and 45 clinically healthy women of comparable age. The patients were divided into the following groups depending on the localization of the myomatous node: interstitial-subserous localization (n = 17), subserous localization (n = 16), submucosal localization (n = 15), interstitial-submucosal localization (n = 15), interstitial localization (n = 15). In 34.6 % patients, the number of myoma nodes was 4–6, in 46.2 % women there were 2–3 nodes, in 19.2 % – 1 node.Determination of the serum concentration of sCD50, sCD54 and sCD95 molecules was performed using a two-site enzyme immunoassay and expressed in conventional units (U / ml).Results. The average serum concentration of sCD95, sCD54 and sCD50 in all patients with UF was significantly higher than in the control group (p <0.05). The maximum level of the tested molecules was found in UF patients with submucosal localization and the presence of one myomatous node.Conclusions. The detected increase in sCD50, sCD54 and sCD95 levels in UF patients indicates the participation of these proteins in the immunopathogenesis of this pathology. The imbalance in studied proteins levels is most pronounced in submucosal localization of fibroids, which may indicate an unfavorable course of the disease and serve as an additional criterion for selecting patients in the preoperative period.
Study and selection of optimal rheological characteristics of piracetam gel compositions for intranasal use
Authors: Stepanova E. F. , Kovtun E. V. , Bunyatyan N. D. , Dadou Moneb M. Y. , Privalov I. M. , Pleten A. P. 
Published: October 2024

Background. One of the important areas of pharmaceutical research is the creation of new, as well as improvement of existing, in-demand dosage forms, using already known drugs as active substances. Current issues are the development of drugs that activate the integrative properties and functions of the brain, as well as increase the body’s resistance to aggressive influences. Nootropics, namely piracetam and its analogues, are successfully used in neurological, psychiatric and drug treatment practice. At the same time, the intranasal route of administration is attractive for combined and longterm therapy of these diseases. when developing new intranasal compositions, the issues of choosing the optimal combination of excipients that allow the dosage form to be easily distributed in the nasal cavity must be resolved. The selection of optimal compositions based on consistency properties is possible on the basis of rheological research data, which allows not only to predict the properties of the dosage form being developed, but also to select the required composition and ratio of components. In addition, an important indicator of the quality of soft dosage forms that affects consumer properties is their stability during transportation and storage, as well as such an indicator as spreadability.Aim. Selection of the optimal composition of the gel with piracetam based on rheological characteristics and predicting the thermal and colloidal stability of the gel structure.Materials and methods. Carboxymethyl cellulose, chitosan and carbopol were chosen as the gel base. The rheological characteristics of the samples were studied by rotational viscometry on a Fungilab Premium viscometer (Spain). Data were obtained and collected using Fungilab Data Boss software; additional data processing was carried out using Microsoft Excel.Results. The gelling agent was selected and its rheological characteristics were determined.Conclusion. The optimal composition of excipients piracetam gel was selected taking into account the basic rheological parameters.
The Therapeutic Potential of Agarwood as an Antimicrobial and Anti-inflammatory Agent: A Scoping Review
Authors: Abd Rashed Aswir , Jamilan Mohd Azerulazree , Abdul Rahman Salina , Amin Nordin Fatimah Diana , Mohd Nawi Mohd Naeem 
Published: October 2024

Microorganisms such as bacteria, viruses and fungi are frequently the cause of infections. Antimicrobial agents, such as antibiotics, antivirals, and antifungals, are used to target and eliminate these infectious agents. Treating infections is crucial to prevent them from spreading, causing complications, or becoming chronic. On the other hand, inflammation is a natural response of the immune system to injury, infection, or irritation. While acute inflammation is a natural and protective process, chronic inflammation can contribute to various health issues, including autoimmune diseases, allergies, and chronic conditions like arthritis. Although herbal remedies have been used for centuries and can be effective in certain situations, it is crucial to use them with caution. Not all herbal remedies are supported by scientific evidence, and their safety and efficacy can vary. Thus, we conducted this review to determine the potential health benefits of agarwood as an antimicrobial and anti-inflammatory agent. Original articles were searched in three databases (PubMed, Scopus and Google Scholar) from the year 2013 to 2023 using the Medical subject heading (MeSH) terms “antimicrobial” and/or “anti-inflammatory”, crossed with the term “agarwood”. Synonyms and relevant search terms were also searched. The most studied agarwood for antimicrobial and anti-inflammatory agents is Aquilaria sinensis. Some studies have shown its potential application as a biopesticide for mosquito control and as a potent inhibitor for fungi, including Lasiodiplodia theobromae, Fusarium oxysporum, and Candida albicans. Moreover, it is capable of inhibiting Bacillus subtilis and Staphylococcus aureus activities. In conclusion, agarwood and its isolates are worthy of further biomedical investigation and could be developed as potential candidates for the treatment or prevention of various microbial and inflammatory diseases. This review reveals that despite the absence of clinical trials, agarwood exhibits antimicrobial and anti-inflammatory properties.
WITHDRAWN: A Review Study of the Existential Problems of Substance Addicted Adolescents in Turkey: A Qualitative Study
Authors: Kızılkaya Mehtap , Toker Sema , Uzunoğlu Gülçin 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Multi-omics characterization of chronic social defeat stress recall-activated engram nuclei in Arc-GFP mice
Authors: Chongtham Monika Chanu , Hartwich Dewi , Todorov Hristo , Ruffini Nicolas , Weis Eva , Linke Matthias , Schweiger Susann , Zechner Ulrich , Gräff Johannes , Lutz Beat , Gerber Susanne , Winter Jennifer 
Published: October 2024

Abstract

Susceptibility to chronic social stressors often results in the development of mental health disorders including major depressive and anxiety disorders. In contrast, some individuals remain resilient even after repeated stress exposure. Understanding the molecular drivers behind these divergent phenotypic outcomes is crucial. However, previous studies using the chronic social defeat (CSD) stress model have been limited by the use of bulk tissues investigating single omics domains. To overcome these limitations, here, we applied the CSD mouse model to Arc-GFP mice for investigating the mechanistic divergence between susceptibility and resilience, specifically in stress recall-activated engram nuclei. By conducting an in-depth analysis of the less-known differential methylome landscape in the ventral hippocampal engrams, we noted unique phenotype-specific alterations in multiple biological processes with an overrepresentation of GTPase-related mechanisms. Interestingly, the differentially methylated regions were enriched in ETS transcription factor binding sites (TFBSs), important targets of the Ras-ETS signaling pathway. This differential methylation in the ETS TFBSs could form the basis of persisting stress effects long after stressor exposure. Furthermore, by integrating the methylome modifications with transcriptomic alterations, we resolved the GTPase-related mechanisms differentially activated in the resilient and susceptible phenotypes with alterations in endocytosis overrepresented in the susceptible phenotype. Overall, our findings implicate critical avenues for future therapeutic applications.
Valorization of bioactive metabolites from Trichodesmium erythraeum bloom biomass for vector borne disease control, bactericidal and anticancer therapy
Authors: Surya Parthasarathy , Seema Siddharthan , Salmen Saleh H. , Aljawdah Hossam M. , Sundaramanickam Arumugam 
Published: October 2024

Abstract

In the marine environment, algae are regarded as globally distributed entity. The excessive accumulation of nutrients such as nitrogen or phosphorus causes an algal bloom, which is caused by the rapid growth of microscopic algae rather than macroscopic ones. Even though it has negative effects, its significance in terms of biological usage was limited to experimental perspective. In our study, we have utilized algal waste biomass of Trichodesmium erythraeum to valorize its natural metabolites for the vector control, bacterial inhibition and anticancer study. Among the solvents, the methanolic extract produced significant mosquitocidal action against A. stephensi, A. aegypti, and C. quinquefasciatus. The methanolic extract of T. erythraeum were found to inhibit the growth of clinical pathogens including B. subtilis, P. mirabilis, S. aureus, E. coli and K. pneumoniae. Further, the methanol extract mediated anticancer effect was assessed on non-small cell lung cancer cell lines. Moreover, the extract displayed no impact on non-target organism. FT-IR results suggested the incidence of alkanes (–C ≡ C–H: C–H stretch), nitrile (C ≡ N), (primary amines (N–H bend), aliphatic amines (C–N stretch), alkenes (= C–H bend) and nitro compounds (N–O asymmetric stretch). GCMS analysis listed the series of compounds such as Hexadecanoic acid, Bicyclo [10.1.0] tridec-1-ene, Glycidol stearate, Tricyclo [20.8.0.0 (7, 16)] triacontane, 1(22), 7 (16)-diepoxy- and Piperidine played vital role in vector control and bactericidal action. This study specifies on usage of algal metabolites and the obtained results imply that it might be useful for essential medicinal applications.
The Role of Quantum Metastability and the Perspective of Quantum Glassiness in Kitaev’s Fractional Spin Dynamics: An NMR Study
Authors: Papavassiliou Georgios , Papawassiliou Wassilios , Lazaridis Nicolas , Mpanga Eunice Mumba , Koppe Jonas , Panopoulos Nikolaos , Karagianni Marina , Gkoura Lydia , Berthelot Romain , Fardis Michael , Pell Andrew 
Published: October 2024

Abstract

The suppression of magnetic order and the detection of a half-quantized thermal Hall effect in α-RuCl3 under an external magnetic field have sparked significant debate, whether these phenomena point to spin fractionalization, as posited by the Kitaev quantum spin liquid (QSL) model, or if they arise from a more conventional mechanism in an antiferromagnetically ordered spin state. Here, through 23Na NMR relaxation measurements on the layered cobaltate Na2Co2TeO6 at two distinct magnetic fields (4.7 and 9.4 Tesla), we provide compelling evidence supporting a variant interpretation. While upon cooling, the NMR relaxation times align with the temperature dependence predicted by Kitaev’s fractional spin excitations, below 10 K, a dynamically heterogeneous state is detected with Quantum Spin Glass (QSG) characteristics. In this state, the spin fractionalization dynamics unfold over markedly different time scales, and are characterized by quantum metastability, inducing prolonged equilibration as T→0. This observation challenges the prevailing view of a primarily homogeneous QSL state, as the ground state of tangible Kitaev systems.
miRNA-223-5p Inhibits Hypoxia-induced Apoptosis of BMSCs and Promotes Repair in Legg-Calvé-Perthes Disease rabbit model by Targeting CHAC2 and Activating the Wnt/β-catenin Signaling Pathway
Authors: Yang Jiafei , Zhang Tianjiu , Zhu Xingtao , He Zhexi , Jiang Xu , Yu Song 
Published: October 2024

Abstract

Legg-Calvé-Perthes disease (LCPD) involves femoral head osteonecrosis due to disrupted blood supply, leading to joint deformity and early osteoarthritis. This study examines the role of miRNA-223-5p in regulating hypoxia-induced apoptosis and promoting osteogenesis in bone marrow mesenchymal stem cells (BMSCs). Using a juvenile New Zealand white rabbit model of LCPD created through femoral neck ligation, we transfected BMSCs with miR-223-5p mimics, inhibitors, and controls, followed by hypoxic exposure. We assessed the impact of miR-223-5p on BMSC apoptosis using qPCR, Western blotting, and dual-luciferase reporter assays, focusing on the Wnt/β-catenin signaling pathway. In vivo, we evaluated the effects of transplanting miR-223-5p-overexpressing BMSCs into the LCPD model. Our findings indicate that miR-223-5p is downregulated under hypoxic conditions. Overexpression of miR-223-5p in BMSCs inhibited hypoxia-induced apoptosis and activated the Wnt/β-catenin pathway through direct targeting of CHAC2. In vivo, miR-223-5p-overexpressing BMSCs enhanced femoral head osteogenesis and reduced necrosis in the LCPD model. These results suggest that miR-223-5p inhibits hypoxia-induced apoptosis in BMSCs by targeting CHAC2 and activating the Wnt/β-catenin pathway, proposing miR-223-5p as a promising target for improving bone repair in ischemic conditions.