bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double surrogate modeling usage in PSO
Authors: Pehlivanoglu Volkan Yasin 
Published: September 2017

Purpose
The purpose of this paper is to improve the efficiency of particle optimization method by using direct and indirect surrogate modeling in inverse design problems.

Design/methodology/approach
The new algorithm emphasizes the use of a direct and an indirect design prediction based on local surrogate models in particle swarm optimization (PSO) algorithm. Local response surface approximations are constructed by using radial basis neural networks. The principal role of surrogate models is to answer the question of which individuals should be placed into the next swarm. Therefore, the main purpose of surrogate models is to predict new design points instead of estimating the objective function values. To demonstrate its merits, the new approach and six comparative algorithms were applied to two different test cases including surface fitting of a geographical terrain and an inverse design of a wing, the averaged best-individual fitness values of the algorithms were recorded for a fair comparison.

Findings
The new algorithm provides more than 60 per cent reduction in the required generations as compared with comparative algorithms.

Research limitations/implications
The comparative study was carried out only for two different test cases. It is possible to extend test cases for different problems.

Practical implications
The proposed algorithm can be applied to different inverse design problems.

Originality/value
The study presents extra ordinary application of double surrogate modeling usage in PSO for inverse design problems.
How family firms execute open innovation strategies: the Loccioni case
Authors: Casprini Elena , De Massis Alfredo , Di Minin Alberto , Frattini Federico , Piccaluga Andrea 
Published: September 2017

PurposeThis paper aims to shed light on how family firms execute open innovation strategies by managing internal and external knowledge flows.Design/methodology/approachFirst, through a comprehensive literature review, the paper identifies the barriers to the acquisition and transfer of knowledge in open innovation processes. Second, it presents and discusses the results of an exploratory case study on Loccioni, an Italian family firm providing high-tech measurement solutions, highlighting how this family firm managed to overcome the barriers in executing an open innovation strategy.FindingsThe case study shows that Loccioni faced specific challenges in acquiring and transferring knowledge in its open innovation processes and developed two idiosyncratic capabilities – labelled imprinting and fraternization – that helped the firm overcome the barriers to knowledge acquisition and transfer. The analysis shows that these two capabilities are enabled by the distinctive goals and social capital characterizing family firms.Originality/valueThe paper creates a link between open innovation and family business research with an empirically grounded model illustrating how the idiosyncratic capabilities of a family firm help overcome the critical barriers to the acquisition and transfer of knowledge in executing an open innovation strategy.
Reputational leadership and preference similarity: Explaining organisational collaboration in bank policy networks
Authors: JAMES SCOTT , CHRISTOPOULOS DIMITRIS 
Published: September 2017

AbstractThis article contributes to our understanding of the formation of policy networks. Research suggests that organisations collaborate with those that are perceived to be influential in order to access scarce political resources. Other studies show that organisations prefer to interact with those that share core policy beliefs on the basis of trust. This article seeks to develop new analytical tools for testing these alternative hypotheses. First, it measures whether perceptions of reputational leadership affect the likelihood of an organisation being the target or instigator of collaboration with others. Second, it tests whether the degree of preference similarity between two organisations makes them more or less likely to collaborate. The article adopts a mixed‐methods approach, combining exponential random graph models (ERGM) with qualitative interviews, to analyse and explain organisational collaboration around United Kingdom banking reform. It is found that reputational leadership and preference similarity exert a strong, positive and complementary effect on network formation. In particular, leadership is significant whether this is measured as an organisational attribute or as an individually held perception. Evidence is also found of closed or clique‐like network structures, and heterophily effects based on organisational type. These results offer significant new insights into the formation of policy networks in the banking sector and the drivers of collaboration between financial organisations.
Identification of 1‐(2,3‐dihydro‐1H‐inden‐5‐yl)‐2‐(ethylamino)pentan‐1‐one (bk‐IVP) in a Seized Drug Exhibit
Authors: Yovanovich Audra Curry , Goodpaster John V. , Minto Robert E. 
Published: September 2017

AbstractTo circumvent the law by evading regulation and obscuring their identities in routine analyses, numerous substituted cathinones have entered the illicit drug market. These compounds have been coined “bath salts” by users. In the described case, the laboratory received an unknown white powder for controlled substances identification. The sample could not be immediately identified using standard methods and procedures. Ultimately, the structure was elucidated using GC‐MS, NMR, FTIR, GC‐SPIR, UV, and color tests to be 1‐(2,3‐dihydro‐1H‐inden‐5‐yl)‐2‐(ethylamino)pentan‐1‐one (bk‐IVP), a cathinone analog with a rarely observed nonoxygenated bicyclic ring system. Features of spectra and chemical tests are reported that distinguish this class of cathinones from heterocyclic analogs.
The Nursing Diagnosis Disturbed Thought Processes: An Integrative Review
Authors: Escalada‐Hermández Paula , Marín‐Fernández Blanca 
Published: September 2017

PURPOSETo analyze and synthetize the existing scientific literature in relation to the nursing diagnosis disturbed thought processes (DTPs) (00130).METHODSAn integrative review was developed, identifying relevant papers through a search of international and Spanish databases and the examination of key manuals.FINDINGSTheoretical papers propose modifications for the nursing diagnosis DTPs. Most of the research papers offer data about its frequency in different clinical settings.CONCLUSIONSThere exists an interest in the nursing diagnosis DTPs. However, the available evidence is not very extensive and further work is necessary in order to refine this nursing diagnosis.IMPLICATIONS FOR NURSING PRACTICEThe re‐inclusion of DTPs in the NANDA‐I classification will specially contribute to increment its utility in mental healthcare.
Description of three new species ofPhyllocnistisZeller, 1848 (Lepidoptera: Gracillariidae), from theAtlantic Forest, southBrazil, with notes on natural history and phylogeny
Authors: Brito Rosângela , Mielke Olaf H H , Gonçalves Gislene L , Moreira Gilson R P 
Published: September 2017

AbstractThree new species ofPhyllocnistisZeller (Phyllocnistinae) from the Atlantic Forest, Rio Grande do Sul (RS) state of Brazil, are described.Phyllocnistis oureasp. nov. is a leaf miner ofBaccharis anomalaDC. (Asteraceae) in the municipality of Montenegro. The other two species,P. phoebussp. nov. andP. selenesp. nov. were found miningBegonia fruticosa(Klotzsch) A.DC. (Begoniaceae) andDrimys angustifoliaMiers (Winteraceae) leaves, respectively, in the municipality of São Francisco de Paula. Information regarding the natural history of each species is provided. The specific status and phylogenetic relationships, including other members ofPhyllocnistis, are inferred from DNA barcode (COI) sequences. Immature stages of the three species are typical sap‐feeding instars, followed by a final spinning instar. Differences found in pupal characters and the colour pattern of the fasciae of adult fore wings were stable and thus used to delimit these new species. Thus, five species ofPhyllocnistisare now known from Brazil, four of them from the Atlantic Forest. For the first time, we recorded Begoniaceae as a host plant family for Gracillariidae.
Histological characterization of umbilical cord in alpaca (Vicugna pacos)
Authors: Barrios‐Arpi L. M. , Rodríguez Gutiérrez J.‐L. , Lopez‐Torres B. 
Published: September 2017

SummaryThe histomorphometric features of umbilical cord constituents in seven foetuses of alpaca (Vicugna pacos) from Cerro de Pasco, Department, Peru, were determined. Sections of 2–5 cm of umbilical cord were fixed in 10% neutral buffered formalin and processed for light microscopy. Standard histological slides stained with haematoxylin and eosin, Masson's trichrome and Van Gieson's trichrome were obtained. Histologically, common features of umbilical artery and vein were observed as well as mucous connective tissue, some cell features that compound this tissue constituted by cells presented features of myofibroblasts. Among most important findings that were observed, the lumen of umbilical vein was obliterated into star‐shaped form with the thinner umbilical artery wall; the smooth muscles and fibroblast were comparatively more in number in umbilical artery than that of umbilical vein, and the tunica media was larger in dimension than the tunica adventitia in umbilical vein. Conclusively, this histological study features an observation of the umbilical cord of alpaca foetuses and shows the similarity between them and those of other mammal species, including dromedaries and South American camelids.
Comparable Outcome of Out‐of‐Hospital Cardiac Arrest and In‐Hospital Cardiac Arrest Treated With Extracorporeal Life Support
Authors: Ellouze Omar , Vuillet Melitine , Perrot Justine , Grosjean Sandrine , Missaoui Anis , Aho Serge , Malapert Ghislain , Bouhemad Belaid , Bouchot Oliver , Girard Claude 
Published: September 2017

AbstractExtracorporeal life support (ECLS) has shown benefits in the management of refractory in‐hospital cardiac arrest (IHCA) by improving survival. Nonetheless, the results concerning out‐of‐hospital refractory cardiac arrests (OHCA) remain uncertain. The aim of our investigation was to compare survival between the two groups. We realized a single‐center retrospective, observational study of all patients who presented IHCA or OHCA treated with ECLS between 2011 and 2015. Multivariate analysis was realized to determine independent factors associated with mortality. Over the 4‐year period, 65 patients were included, 43 in the IHCA group (66.2%), and 22 (33.8%) in the OHCA group. The duration of low flow was significantly longer in the OHCA group (60 vs. 90 min, P = 0.004). Survival to discharge from the hospital was identical in the two groups (27% in the OHCA group vs. 23% in the IHCA group, P = 0.77). All surviving patients in the OHCA group had a cerebral performance categories score of 1–2. In multivariate analysis, we found that the initial lactate level and baseline blood creatinine were independently associated with mortality. We found comparable survival and neurological score in patients who presented IHCA and OHCA treated with ECLS. We believe that appropriate selection of patients and optimization of organ perfusion during resuscitation can lead to good results in patients with OHCA treated with ECLS.
Inverse Probability Weighted Cox Regression for Doubly Truncated Data
Authors: Mandel Micha , de Uña-Álvarez Jacobo , Simon David K. , Betensky Rebecca A. 
Published: September 2017

SummaryDoubly truncated data arise when event times are observed only if they fall within subject-specific, possibly random, intervals. While non-parametric methods for survivor function estimation using doubly truncated data have been intensively studied, only a few methods for fitting regression models have been suggested, and only for a limited number of covariates. In this article, we present a method to fit the Cox regression model to doubly truncated data with multiple discrete and continuous covariates, and describe how to implement it using existing software. The approach is used to study the association between candidate single nucleotide polymorphisms and age of onset of Parkinson's disease.
Synthesis, quality control, and bio‐evaluation of 99mTc‐cyclophosphamide
Authors: Bokhari Tanveer Hussain , Roohi Samina , Hina Saira , Akbar Muhammad Usman , Sohaib Muhammad , Iqbal Munawar 
Published: September 2017

Cancer is found to be the leading cause of death worldwide characterized by uncontrolled cell division. Nuclear medicines imaging using radiopharmaceuticals have pronounced potential for the diagnosis and treatment of cancers. Cyclophosphamide (CPH) is an antineoplastic drug which targets selectively cancer cells. In the present work, labeling of CPH with Tc‐99m is performed for diagnostic purpose, which gave labeling yield as high as 99% using 20 μg SnCl2·2H2O, 200 μg of ligand at pH 7 for 10 min reaction time at room temperature. The characterization of the prepared complex was performed using ITLC, electrophoresis, and HPLC. In vitro stability was analyzed in the presence of human serum at 37°C which has maximum value of 94 ± 0.5. The biodistribution studies of 99mTc‐CPH were performed in normal and tumor bearing Swiss Webster mice. The high accumulation of 99mTc‐CPH was observed in liver and tumours respectively at 4 hr after injection. Biodistribution results revealed that 99mTc‐CPH may be a potential tumour diagnostic agent simultaneously with chemotherapy.
Validation of the MASK‐rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control
Authors: Caimmi D. , Baiz N. , Tanno L. K. , Demoly P. , Arnavielhe S. , Murray R. , Bedbrook A. , Bergmann K. C. , De Vries G. , Fokkens W. J. , Fonseca J. , Haahtela T. , Keil T. , Kuna P. , Mullol J. , Papadopoulos N. , Passalacqua G. , Samolinski B. , Tomazic P. V. , Valiulis A. , van Eerd M. , Wickman M. , Annesi‐Maesano I. , Bousquet J. ,   the MASK Study Group
Published: September 2017

SummaryBackgroundVisual Analogue Scale (VAS) is a validated tool to assess control in allergic rhinitis patients.ObjectiveThe aim of this study was to validate the use of VAS in the MASK‐rhinitis (MACVIA‐ARIA Sentinel NetworK for allergic rhinitis) app (Allergy Diary) on smartphones screens to evaluate allergic rhinitis symptoms and disease control.MethodsEach user filled 4 different VAS measuring overall, nasal, ocular, and asthma symptoms at least once. Following COSMIN guidelines, we evaluated internal consistency, (Cronbach's alpha coefficient and test‐retest), reliability (intraclass correlation coefficients), sensitivity, and acceptability of the MASK‐Rhinitis VAS.ResultsBetween 1 August 2015 and 31 July 2016, the app was used 14 612 times in 15 countries. A total of 1225 users used it more than once, during the evaluated period. The tool resulted to be statistically satisfactory, showing excellent internal consistency (Cronbach's test > 0.84, test‐retest > 0.7), reliability (>0.9), and acceptability. In addition, the tool had a good sensitivity when users (n = 521) answered the VAS twice in less than 3 hours.Conclusions and Clinical RelevanceThe MASK‐rhinitis VAS is a reliable and valid tool to assess allergic control on smartphone screens, at the population level.
Organoid technology for brain and therapeutics research
Authors: Wang Zhi , Wang Shu‐Na , Xu Tian‐Ying , Miao Zhu‐Wei , Su Ding‐Feng , Miao Chao‐Yu 
Published: September 2017

SummaryBrain is one of the most complex organs in human. The current brain research is mainly based on the animal models and traditional cell culture. However, the inherent species differences between humans and animals as well as the gap between organ level and cell level make it difficult to study human brain development and associated disorders through traditional technologies. Recently, the brain organoids derived from pluripotent stem cells have been reported to recapitulate many key features of human brain in vivo, for example recapitulating the zone of putative outer radial glia cells. Brain organoids offer a new platform for scientists to study brain development, neurological diseases, drug discovery and personalized medicine, regenerative medicine, and so on. Here, we discuss the progress, applications, advantages, limitations, and prospects of brain organoid technology in neurosciences and related therapeutics.
LncRNA‐ATB: An indispensable cancer‐related long noncoding RNA
Authors: Li Jinglin , Li Zhenglong , Zheng Wangyang , Li Xinheng , Wang Zhidong , Cui Yunfu , Jiang Xingming 
Published: September 2017

AbstractObjectivesLong non‐coding RNAs (lncRNAs) are a group of non‐protein‐coding RNAs that are greater than 200 nucleotides in length. Increasing evidence indicates that lncRNAs, which may serve as either oncogenes or tumour suppressor genes, play a vital role in the pathophysiology of human diseases, especially in tumourigenesis and progression. Deregulation of lncRNAs impacts different cellular processes, such as proliferation, dedifferentiation, migration, invasion and anti‐apoptosis. The aim of this review was to explore the molecular mechanism and clinical significance of long non‐coding RNA‐activated by transforming growth factor β (lncRNA‐ATB) in various types of cancers.Materials and methodsIn this review, we summarize and analyze current studies concerning the biological functions and mechanisms of lncRNA‐ATB in tumour development. The related studies were obtained through a systematic search of Pubmed, Web of Science, Embase and Cochrane Library.ResultsLong non‐coding RNAs‐ATB is a novel cancer‐related lncRNA that was recently found to exhibit aberrant expression in a variety of malignancies, including hepatocellular carcinoma, colorectal cancer, gastric cancer, and lung cancer. Dysregulation of lncRNA‐ATB has been shown to contribute to proliferation, migration and invasion of cancer cells. Long non‐coding RNAs‐ATB promotes tumourigenesis and progression mainly through competitively binding miRNAs to induce epithelial‐mesenchymal transition (EMT).ConclusionsLong non‐coding RNAs‐ATB likely represents a feasible cancer biomarker or therapeutic target.
Procalcitonin, erythrocyte sedimentation rate and C‐reactive protein in acute pulmonary exacerbations of cystic fibrosis
Authors: Loh Geoffrey , Ryaboy Ilya , Skabelund Andrew , French Alicia 
Published: September 2017

AbstractIntroductionAcute pulmonary exacerbations of cystic fibrosis (APECF) are a leading cause of morbidity and mortality among patients with cystic fibrosis (CF). APECF require frequent administration of antibiotics and subsequently lead to development of resistant organisms.ObjectivesThe aim of this study was to identify inflammatory markers that may be help identify need for antibiotics and exacerbation as well as predict risk of exacerbations.MethodsA total of 17 patients were enrolled, and baseline erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP) and procalcitonin levels were obtained in addition to obtaining these levels during admissions for APECF.ResultsA total of 28 APECF were recorded. ESR and CRP significantly increased during exacerbation (P < .01 for both). Procalcitonin did not increase during exacerbations. Baseline elevations in ESR and CRP increased risk of an exacerbation (RR = 2.3 and 4.5, respectively).ConclusionsESR and CRP are useful markers for CF exacerbations, as levels rise with exacerbations. Baseline elevations in ESR and CRP were noted to show an increased risk for CF exacerbations. Procalcitonin, in contrast, is not a useful inflammatory marker.
Regional‐scale environmental drivers of highly endemic temperate fish communities located within a climate change hotspot
Authors: Galaiduk Ronen , Halford Andrew R. , Radford Ben T. , Moore Cordelia H. , Harvey Euan S. 
Published: September 2017

AbstractAimWe used modelled environmental data to identify important drivers of bioregional patterns of demersal fish assemblages characterized by a high proportion of endemic species.LocationOf 1,600 km of coastal marine environment in south‐western Australia.MethodsWe compiled data from 1090 stereo‐BRUVs samples; a total of ~55,000 individuals belonging to 219 demersal fish species. Multivariate Regression Trees and Distance‐based Linear Models distinguished which biological and/or environmental variables, amongst an initial set of 49, were most correlated to observed patterns of demersal fish assemblage structure. Indicator species analysis identified fish species most representative of the assemblage types.ResultsThe most parsimonious model (constrained by five benthic variables and one spatial variable) explained 42% of the variation in spatial patterns of fish community structure. Canopy‐forming seaweeds were the major benthic drivers, and, when found on structurally complex hard habitat, supported the highest diversity of species after sites dominated by hard coral cover. Indicator species analysis revealed that 28 of 35 significant species for this habitat type were endemics with fish assemblages associated with these habitats often spatially restricted to tens of kilometres.Main conclusionsDemersal fish assemblage composition and biogeographical ranges in south‐western Australia are strongly influenced by the presence of canopy‐forming macroalgae. Canopy‐dominated habitats have already been subject to catastrophic temperature‐related die‐offs in the northern part of this study, indicating its vulnerability to temperature‐driven climate change. These results highlight not only the crucial role of this habitat in supporting endemic fish communities in the region, and the tenuous nature of their existence, but also the challenges facing marine managers who, unable to manipulate the influence of climate change variables, can only focus on alleviating stresses operating on local scales.