bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do institutional gender regimes affect formal reporting processes for sexual harassment? A qualitative study of UK higher education
Authors: Bull Anna , Shannon Erin 
Published: October 2024

AbstractFormal complaints and disciplinary processes constitute a mandatory aspect of organizational responses for addressing sexual harassment in many jurisdictions. However, previous research has found that reporting parties are not well served by such processes. In particular, Ahmed (Complaint!; 2021) argues that the institutional climate that enables harassment or discrimination to occur—including its gendered dynamics—also shapes how complaints about harassment are handled. Building on Ahmed's work, this article analyses how gender “gets into” formal reporting processes for sexual harassment within organizations. It draws on interviews with 18 students and staff who went through a formal institutional reporting process for gender‐based violence or harassment in UK higher education between 2016 and 2021. Using Connell's theorization of “gender regimes,” we outline how “dimensions of gender” within organizations affected different stages of formal reporting processes, including how evidence was gathered during reporting processes, as well as how it was assessed. These findings demonstrate that gender regimes—via gender relations of power, gendered “attachments and investments,” and “gender‐neutral” processes—can override formal processes and affect outcomes of sexual harassment reporting. These findings explain how gender regimes contribute to the failure of sexual harassment complaints to be upheld within organizations.
Rural development as the propagation of regional ‘communities of values’: A case study of local discourses promoting social innovation and social sustainability
Authors: Stoustrup Sune Wiingaard 
Published: October 2024

AbstractDiscourses on rural areas and their development concurrently encompass both negative narratives of them dying out and discussions on how to constitute future visions for a ‘living’, ‘good’ and ‘sustainable’ countryside to work towards. As a solution, ‘social innovation’ has been proposed to counter the economic, demographic and sociocultural challenges disadvantaged rural regions are facing. Accordingly, this article contributes to the growing literature on the dynamics of social innovation initiatives by investigating how rural areas and their communities are communicatively re‐constructed, as part of socio‐spatial processes emerging from the work of rural development initiatives, fostering potential social change towards more sustainable societies. Building on fieldwork from the rural Austrian region of Mühlviertel, it is shown how social innovation aiming at instigating positive territorial developments is linked to intertwined processes of the re‐figuration of social bonds and re‐figuration of space, which is centred around the propagation of regional ‘community of values’ founded on ideas about changing values and social sustainability.
Replication kinetics and cytopathic effect of feline calicivirus in feline corneal epithelial cells
Authors: Saade Daniela I. , Liu Chin‐Chi , Mills Erinn P. , Stanfield Brent , Thieulent Côme J. , Chouljenko Vladimir N. , Emelogu Ugochi , Carter Renee T. , Camacho‐Luna Pilar , Lewin Andrew C. 
Published: October 2024

AbstractObjectiveTo determine the replication kinetics and cytopathic effect (CPE) of feline calicivirus (FCV) in feline corneal epithelial cells (FCEC).Animals StudiedSeven archived FCV isolates and one archived feline herpesvirus type 1 (FHV‐1) isolate, previously obtained from eight domestic short hair cats.ProceduresFCV RNA was extracted for sequencing using Illumina MiSeq, to identify three genomically diverse isolates for further testing. Following reference‐based assembly, viral genomes were annotated and assessed. Superficial keratectomies were performed to isolate the corneal epithelium of cats and the cells were cultured in vitro. FCEC were infected with the three chosen FCV isolates and one FHV‐1 isolate at two different multiplicity of infection ratios (MOIs, 0.1 and 0.01 PFU/cell) and virus titration was assessed at 0, 2, 6, 12, 24, and 48 h post‐infection (hpi). Viral identity was confirmed by RT‐qPCR.ResultsThree genomically diverse FCV isolates were chosen for further assessment in the FCEC model. All infections of FCEC with FCV led to visible CPE, characterized by epithelial cell rounding and detachment from the plate by 24 hpi, while FHV‐1 led to visible CPE within 48 hpi. All three of the FCV isolates replicated effectively in FCEC at both 0.1 and 0.01 MOI, with a peak increase in titer approximately 12–24 hpi.ConclusionsThe results support the possible role of FCV as a primary pathogen of the feline ocular surface. FCV replicates in FCEC in vitro, leading to profound CPE.
Rational noncrossing Coxeter–Catalan combinatorics
Authors: Galashin Pavel , Lam Thomas , Trinh Minh‐Tâm , Williams Nathan 
Published: October 2024

AbstractWe solve two open problems in Coxeter–Catalan combinatorics. First, we introduce a family of rational noncrossing objects for any finite Coxeter group, using the combinatorics of distinguished subwords. Second, we give a type‐uniform proof that these noncrossing Catalan objects are counted by the rational Coxeter–Catalan number, using the character theory of the associated Hecke algebra and the properties of Lusztig's exotic Fourier transform. We solve the same problems for rational noncrossing parking objects.
Material Removal Rate of Face-Milled Bevel Gears Based on a Ring-Dexel Cutting Simulation
Authors: Shih Yi-Pei , Wang Yu-Chieh , Wei Bo-Lin , Chen Kuan-Hung 
Published: October 2024

Abstract
Face milling is not only a primary machining technique for the mass production of bevel gears, but it has also become a standardized process integrated into computer numerical control (CNC) bevel gear-cutting machines in the last two decades. Controlling suitable feed rates for face milling is one of the most direct and pivotal factors influencing processing efficiency for CNC machines. Despite being programmed through numerical codes, the feed rates provided by the gear machines most rely on experiential insights rather than optimization. Therefore, leveraging material removal rate (MRR) directly correlates with machining power and will hold immense potential for optimizing feed rates and enhancing efficiency. Because commercial software solutions cannot accurately predict the MRR for face milling operations, this paper uses a novel ring-dexel-based model for cutting simulation to address this issue. The main aim of this model is to provide a more precise prediction of the MRR across all face milling cuttings. By controlling the cutting depth and generating angle, the ring gear's plunging process and the pinion's single-roll generating process were successfully simulated. Thus, the MRRs through all cutting processes were calculated. Experimental results showed that tool torques are positively correlated with the MRRs. Finally, by appropriately increasing the cutting feed rate based on the MRR, the pinion and ring gear machining times were reduced by 44% and 18%, respectively.
Modeling Stochastical Particle Rebound Based on High-Velocity Experiments
Authors: Hartmann Jan , Koch Christian , Staudacher Stephan 
Published: October 2024

Abstract
Solid particle erosion is a major deterioration process which contributes to performance deterioration of modern axial compressors. The prediction of this deterioration process requires the correct computation of particle movement through the machine and their resulting impacts on the effected components. Especially for particles with high Stokes numbers, the movement is determined mainly by the particle-wall interaction, which is described by coefficients of restitution. Today, they are derived from experiments featuring high particle velocities and target materials, which are representative for turbomachinery applications. In this study, an already published rebound model is optimized for particle materials and velocities within high-pressure compressors. The statistical spread of the rebound experiment is evaluated and the implementation into the rebound model is shown, which improves the prediction capability of the model. The model is implemented into a computational fluid dynamics (CFD) software and numerical simulations are performed. The model is applied to a cylinder test specimen within a sand blast facility. The simulation shows the importance of the stochastics of the rebound, which is often neglected in particle-wall models. Moreover, the numerical study shows requirements for the test specimen and its positioning in the experimental setup, which are prerequisites for the derivation of the coefficients of restitution using two-dimensional particle evaluation equipment.
The Effect of Thermal Cycling on Deposition in an Impingement/Effusion Cooling Geometry
Authors: Gogidze George J. , Bons Jeffrey P. , Lundgreen Ryan 
Published: October 2024

Abstract
Experiments were conducted in a high-pressure deposition facility to study the effect of engine cycling on the successive buildup of deposits as aircraft shut down and power up. The test facility simulates the pressure and temperature environment of a combustor liner or turbine vane cooling circuit. The coolant flow temperature reaches 894 K (1150 °F) and discharges into a 17-atm (250-psi) cavity pressure at a nominal pressure ratio of 1.027. AFRL05 test dust with a 0- to 10-µm size distribution is added to the coolant gas stream. The cooling circuit consists of a double-walled impingement/effusion cooling plate with nominal hole sizes on the order of 0.5 mm. To simulate cycling, the facility is brought up to the desired operating conditions where the first batch of dust is delivered (2–8 g). The facility is then ramped down to ambient conditions. Following a “dwell” period of approximately 24 h, another batch of dust is delivered once the facility is brought back up to the desired operating condition. Test data were acquired for one, two, and four cycles with different dust masses delivered. Values such as discharge coefficient, pressure ratio, Reynolds number, and temperature are used to evaluate the effects of dust deposition on the impingement/effusion plate setup. Dust capture efficiency is shown to be insensitive to cycling whereas flow blockage is negatively impacted by an increased number of cycles for the same total mass delivered. The sloughing of deposit structures during cooling circuit cool down is postulated to be responsible for the observed behavior.
Assessment of the activity and mechanisms of resistance to cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, taniborbactam, zidebactam, nacubactam, xeruborbactam, and ANT3310 in emerging double-carbapenemase-producing Enterobacterales
Authors: Blanco-Martín Tania , López-Hernández Inmaculada , Aracil Belén , González-Pinto Lucía , Aja-Macaya Pablo , Alonso-García Isaac , Rodríguez-Pallares Salud , Sánchez-Peña Lucía , Outeda-García Michelle , Pérez-Vázquez María , Vázquez-Ucha Juan Carlos , Beceiro Alejandro , Pascual Álvaro , Bou Germán , López-Cerero Lorena , Oteo-Iglesias Jesús , Arca-Suárez Jorge ,   on behalf of the GEMARA-SEIMC/CIBERINFEC Study Group on the activity and resistance mechanisms to new β-lactams and β-lactamase inhibitors (PROTECT)
Published: October 2024

ABSTRACT

We aimed to investigate the activity of and mechanisms of resistance to cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations in a nationwide collection of double-carbapenemase-producing Enterobacterales. In all, 57 clinical isolates co-producing two carbapenemases collected from Spanish hospitals during the period 2017–2022 were analyzed. Minimum inhibitory concentration (MIC) values for ceftazidime, ceftazidime/avibactam, aztreonam, aztreonam/avibactam, aztreonam/nacubactam, cefiderocol, cefepime, cefepime/taniborbactam, cefepime/zidebactam, cefepime/nacubactam, imipenem, imipenem/relebactam, meropenem, meropenem/vaborbactam, meropenem/xeruborbactam, and meropenem/ANT3310 were determined by reference broth microdilution. Genetic drivers of resistance were analyzed by whole-genome sequencing (WGS). The collection covered nine carbapenemase associations: VIM + OXA-48 (21/57), NDM + OXA-48 (11/57), KPC + VIM (10/57), KPC + OXA-48 (6/57), IMP + OXA-48 (3/57), NDM + KPC (2/57), NDM + VIM (2/57), NDM + GES (1/57), and KPC + IMP (1/57). Ceftazidime/avibactam, imipenem/relebactam, and meropenem/vaborbactam were the least active options. Aztreonam/avibactam and aztreonam/nacubactam were active against the whole collection and yielded MIC
50
/MIC
90
values of ≤0.25/0.5 mg/L and 1/2 mg/L, respectively. Cefepime/zidebactam (56/57 susceptible), meropenem/xeruborbactam (56/57 susceptible), cefepime/nacubactam (55/57 susceptible), and cefiderocol (53/57 susceptible) were also highly active, with MIC
50
/MIC
90
values ranging from ≤0.25–2 mg/L to 2–4 mg/L, respectively. Meropenem/ANT3310 (MIC
50
/MIC
90
= 0.5/≥64 mg/L; 47/57 susceptible) and cefepime/taniborbactam (MIC
50
/MIC
90
= 0.5/16 mg/L; 44/57 susceptible) also retained high levels of activity, although they were affected by NDM-type enzymes in combination with porin deficiency. Our findings highlight that cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, nacubactam, taniborbactam, zidebactam, xeruborbactam, and ANT3310 show promising activity against double-carbapenemase-producing Enterobacterales.
AAV2 can replicate its DNA by a rolling hairpin or rolling circle mechanism, depending on the helper virus
Authors: Lkharrazi Anouk , Tobler Kurt , Marti Sara , Bratus-Neuenschwander Anna , Vogt Bernd , Fraefel Cornel 
Published: October 2024

ABSTRACT

Adeno-associated virus type 2 (AAV2) is a small, non-pathogenic, helper virus-dependent parvovirus with a single-stranded (ss) DNA genome of approximately 4.7 kb. AAV2 DNA replication requires the presence of a helper virus such as adenovirus type 5 (AdV5) or herpes simplex virus type 1 (HSV-1) and is generally assumed to occur as a strand-displacement rolling hairpin (RHR) mechanism initiated at the AAV2 3′ inverted terminal repeat (ITR). We have recently shown that AAV2 replication supported by HSV-1 leads to the formation of double-stranded head-to-tail concatemers, which provides evidence for a rolling circle replication (RCR) mechanism. We have revisited AAV2 DNA replication and specifically compared the formation of AAV2 replication intermediates in the presence of either HSV-1 or AdV5 as the helper virus. The results confirmed that the AAV2 DNA replication mechanism is helper virus-dependent and follows a strand-displacement RHR mechanism when AdV5 is the helper virus and primarily an RCR mechanism when HSV-1 is the helper virus. We also demonstrate that recombination plays a negligible role in AAV2 genome replication. Interestingly, the formation of high-molecular-weight AAV2 DNA concatemers in the presence of HSV-1 as the helper virus was dependent on an intact HSV-1 DNA polymerase.

IMPORTANCE
AAV is a small helper virus-dependent, non-pathogenic parvovirus. The AAV genome replication mechanism was extensively studied in the presence of AdV as the helper virus and described to proceed using RHR. Surprisingly, HSV-1 co-infection facilitates RCR of the AAV2 DNA. We directly compared AdV5 and HSV-1 supported AAV2 DNA replication and showed that AAV2 can adapt its replication mechanism to the helper virus. A detailed understanding of the AAV replication mechanism expands our knowledge of virus biology and can contribute to increase gene therapy vector production.
Acidocalcisome localization of membrane transporters and enzymes in
Trypanosoma brucei
Authors: Huang Guozhong , Docampo Roberto 
Published: October 2024

ABSTRACT

Acidocalcisomes of
Trypanosoma brucei
are membrane-bounded organelles characterized by their acidity and high content of polyphosphate and cations, like calcium and magnesium. They have important roles in cation and phosphorus storage, osmoregulation, autophagy initiation, calcium signaling, and virulence. Acidocalcisomes of
T. brucei
possess several membrane transporters, pumps, and channels, some of which were identified by proteomic and immunofluorescence analyses and validated as acidocalcisome proteins by their colocalization with the acidocalcisome marker vacuolar proton pyrophosphatase (VP1). Here, we report that a set of membrane transporters and enzymes, which were proposed to be present in acidocalcisomes by the morphological appearance of tagged proteins, colocalize with VP1, validating their character as acidocalcisome proteins.

IMPORTANCE
Acidocalcisomes are acidic organelles rich in polyphosphate and calcium present in a variety of eukaryotes and important for osmoregulation and calcium signaling. Several proteins were postulated to localize to acidocalcisomes based on their morphological characteristics. We provide validation of the localization of ten10 acidocalcisome proteins by their co-localization with enzymatic markers. These findings reveal the roles of acidocalcisomes in the storage of toxic metals, and the presence of enzymes involved in palmitoylation and polyphosphate metabolism.
Universal Adapter Protein Bag3 and Small Heat Shock Proteins
Authors: Zamotina Maria A. , Muranova Lidia K. , Zabolotskii Artur I. , Tyurin-Kuzmin Pyotr A. , Kulebyakin Konstantin Yu. , Gusev Nikolai B. 
Published: October 2024

Abstract
Bag3 (Bcl-2-associated athanogene 3) protein contains a number of functional domains and interacts with a wide range of different partner proteins, including small heat shock proteins (sHsps) and heat shock protein Hsp70. The ternary Bag3–sHsp–and Hsp70 complex binds denatured proteins and transports them to phagosomes, thus playing a key role in the chaperone-assisted selective autophagy (CASA). This complex also participates in the control of formation and disassembly of stress granules (granulostasis) and cytoskeleton regulation. As Bag3 and sHsps participate in multiple cellular processes, mutations in these proteins are often associated with neurodegenerative diseases and cardiomyopathy. The review discusses the role of sHsps in different processes regulated by Bag3.
Testing General Relativity with Black Hole X-Ray Data
Authors: Bambi C. 
Published: October 2024

Abstract
The theory of General Relativity has successfully passed a large number of observational tests without requiring any adjustment from its original version proposed by Einstein in 1915. The past 8 years have seen significant advancements in the study of the strong-field regime, which can now be tested with gravitational waves, X-ray data, and black hole imaging. This is a compact and pedagogical review on the state-of-the-art of the tests of General Relativity with black hole X-ray data.
On the Principle of Relativity of Inertia in Both General and Entangled Relativities
Authors: Minazzoli O. 
Published: October 2024

Abstract
Entangled Relativity is a novel theory of relativity that offers a more economical approach than General Relativity. It successfully recovers both General Relativity and standard quantum field theory within a specific (yet generic) limit. Furthermore, Entangled Relativity precludes the existence of spacetime devoid of the matter that permeates it. Consequently, I argue that Entangled Relativity is not only preferable from the standpoint of Occam’s razor, due to its economical nature, but it also aligns more closely with Einstein’s original vision for a satisfactory theory of relativity.
Systematic review of interventions for mental health, cognition and psychological well-being in long COVID
Authors: Hawke Lisa D , Nguyen Anh T P , Wang Wei , Brown Eric E , Xu Dandan , Deuville Susan , Goulding Suzie , Ski Chantal F , Rossell Susan L , Thompson David R , Rodak Terri , Strudwick Gillian , Castle David 
Published: October 2024

AimsThis systematic review aims to identify and synthesise the publicly available research testing treatments for mental health, cognition and psychological well-being in long COVID.MethodsThe following databases and repositories were searched in October–November 2023: Medline, Embase, APA PsycINFO, Cumulative Index to Nursing and Allied Health Literature, China National Knowledge Internet, WANFANG Data, Web of Science’s Preprint Citation Index, The Cochrane Central Register of Controlled Trials, Clinicaltrials.gov and the WHO International Clinical Trials Registry Platform. Articles were selected if they described participants with long COVID symptoms at least 4 weeks after SAR-CoV-19 infection, reported primary outcomes on mental health, cognition and/or psychological well-being, and were available with at least an English-language summary. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews were followed.ResultsThirty-three documents representing 31 studies were included. Seven tested psychosocial interventions, five pharmaceutical interventions, three natural supplement interventions, nine neurocognitive interventions, two physical rehabilitation interventions and five integrated interventions. While some promising findings emerged from randomised controlled trials, many studies were uncontrolled; a high risk of bias and insufficient reporting were also frequent.ConclusionsThe published literature on treatments for mental health, cognition and psychological well-being in long COVID show that the interventions are highly heterogeneous and findings are inconclusive to date. Continued scientific effort is required to improve the evidence base. Regular literature syntheses will be required to update and educate clinicians, scientists, interventionists and the long COVID community.