bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison Of Medial Arch-Supporting Insoles And Heel Pads In The Treatment Of Plantar Fasciitis
Authors: Malkoc Melih , Korkmaz Ozgur , Kara Adnan , Oltulu Ismail , Say Ferhat 
Published: January 2016

ABSTRACT
Plantar fasciitis is a disorder caused by inflammation of the insertion point of the plantar fascia over the medial tubercle of the calcaneus. Foot orthotics are used to treat plantar fasciitis. Heel pads medialise the centre of force, whereas medial arch supporting insoles lateralise the force. We assessed the clinical results of the treatment of plantar fasciitis with silicone heel pads and medial arch-supported silicone insoles.
We retrospectively reviewed 75 patients with heel pain. A total of 35 patients in the first group were treated with medial arch supporting insoles, and 40 patients in the second group were treated with heel pads. The patients were evaluated with the Visual Analogue Scale (VAS) and the Foot and Ankle Ability Measure (FAAM) at the first and last examinations.
The mean VAS score in the first group was 8.6±1,2 (6-10); the FAAM daily activity score was 66.2±16 (41.2-95.0), and the sporting activity score was 45.4±24,4 (0.1-81) before treatment. At the last follow-up in this group, the mean VAS score was 5.3±1,5 (0-9); the FAAM daily activity score was 83,0±15,1 (55,9-100), and the sporting activity score was 73,5±26,2 (25-100). The mean VAS score in the second group was 8,6±0,9 (7-10); the FAAM daily activity score was 66.4±17 (41.4-95.2), and the sporting activity score was 45.8±24,2 (0.8-81, 3) before the treatment. At the last follow-up in this group, the mean VAS score was 5.5±1,2 (0-9); the FAAM daily activity score was 83.4±14,9 (60, 2-100), and the sporting activity score was 73.8±26 (28-100).
There was no significant difference in the clinical results of both groups. The force distribution by the use of silicone heel pads and medial arch-supported silicone insoles had no effect on the clinical results of the treatment of plantar fasciitis.
Macroeconomic Policy Impact On Oncology-Related Public Expenditure In An Emerging European Market – Signs Of Early Recovery
Authors: Dagovic Aleksandar , Zugic Ana , Jakovljevic Mihajlo B 
Published: January 2016

ABSTRACT
Healthcare financing in Serbia has faced many challenges over the past few decades. One of the most severe challenges is a global macroeconomic recession whose far-reaching consequences deserve particular attention from policymakers in cases of the most demanding major prosperity diseases, such as cancer. The objective of the study was to assess the precise cost matrix of oncology medical care and its chronological evolution during the key years of the macroeconomic recessionary period during 2010-2013.
A retrospective database of hospital discharge invoices was analysed, encompassing 37, 978 hospital admissions and 12, 505 patients during a four-year period. Insight into microeconomic patterns of consumption across groups of medical services was provided. A payer's perspective and one-year time horizon have been adopted.
Total hospital direct medical costs of cancer diagnostics and treatment in the observed tertiary care facility decreased from €7, 411, 446 in 2010 to €5, 715, 884 in 2012 and then increased to an extraordinary €8, 536, 364 in 2013. The costs of oncology nursing care, imaging diagnostics and radiotherapy have increased considerably while those of pharmaceuticals and surgery have decreased radically - completely transforming the resource allocation landscape of public cancer care.
The financial burden of cancer in Serbia is considerable and, unfortunately, expected to increase further in the coming years. Worldwide economic recession and consecutive domestic policy constraints of reimbursement limitations have heavily affected the affordability of cancer treatment for ordinary citizens. Promising signs of market recovery are clearly visible in 2013, which will likely improve both access and equity of medical care in Serbian oncology clinics.
Isolated Carpal Dislocation Of The Trapezium
Authors: Kilinc Bekir Eray , Kara Adnan , Sonmez Mehmet Mesut , Oc Yunus , Camur Savas 
Published: January 2016

ABSTRACT
Trapezium fractures and dislocations of the trapezium are both extremely rare injuries whether they occured with or without fractures of the surrounding bones. Specific radiological images can be difficult to help for the diagnosis. CT scan may be necessary for the diagnosis and adequate treatment. We are presenting an unusual case of volar and radial isolated trapezium dislocation concomitant second metacarpal basis fracture in which is treated by using open reduction and Kirschner wire fixation. In our case, isolated dislocation of trapezium was a result of violent and direct trauma. Different techniques have been proposed to achieve a stable fixation and the treatment outcomes. In our case, open reduction, Kirschner wire fixation and intercarpal ligament repair through dorsal approach are recommended for satisfactory outcomes in similiar cases.
Secondary Haemophagocytic Lymphohistiocytosis – The Differential Diagnosis Dilemma In Paediatrics
Authors: Medovic Rasa , Vuletic Biljana , Raskovic Zorica , Simovic Aleksandra , Nestorovic–Tanaskovic Jelena , Igrutinovic Zoran 
Published: January 2016

ABSTRACT
Secondary haemophagocytic lymphohistiocytosis (SHFLH) is a rare, potentially fatal disorder, most commonly caused by the Epstein–Barr virus. It is characterized by neoplastic proliferation of cells that belong to the monocyte–macrophage system and by varied clinical expression.
A girl aged 3 years and 7 months was hospitalized due to continuing high febricity, yellow skin colouring, hepatosplenomegaly and cytopenia in a complete blood count (CBC). Four weeks before hospitalization, she had a lacunar angina and lymphadenopathy.
A low number of erythrocytes, leukocytes and thrombocytes were noted in CBC, with anaemia and the presence of virocytes in a peripheral blood smear. Biochemical blood analyses indicated hyperbilirubinaemia, increased values of transaminases, lactic dehydrogenase, ferritin, triglycerides, D-dimer, acceleration of the activated partial thromboplastin time and decreased values of fibrinogen, with increased values of C-reactive protein and procalcitonin. Using an ultrasound examination of the abdomen, hepatosplenomegaly was perceived; using echocardiographic examination, pericardium layering was noticed; and using a roentgen graphic picture of the lungs, the presence of pleural effusion was detected. In a bone marrow biopsy, the percentage of blasts did not exceed 25%, and rare chemophagocytes were noticed. Using serologic tests, positivity to Epstein-Barr virus in IgM class was demonstrated.
According to the criteria by Histiocyte Society, there were sufficient criteria to establish a diagnosis of SHFLH. With the exception of symptomatic therapies, according to the protocol for SHFLH treatment, a double antibiotic therapy and IV immunoglobulins were given, to which the patient responded with a clinical and laboratory recovery. Therefore, there was no demand for a treatment protocol with cytostatics or bone marrow transplantation.
To resolve a differential diagnosis dilemma in solving cases of uncertain febrile neutropenia.
Influence Of The Number Of Platelets And Hemoglobin Concentrations In Predicting The Development Of Proteinuria Induced By The Administration Of Bevacizumab
Authors: Dabanovic Vera 
Published: January 2016

Abstract
Bevacizumab neutralizes a key stimulation factor in tumour angiogenesis - vascular endothelial growth factor (VEGF). The origin of VEGF is related to platelets, and the basic stimulus for its production is hypoxia. By neutralizing VEGF, changes occur in the blood that are manifested at the platelet and haemoglobin levels. Study results indicate that proteinuria is a side effect of bevacizumab treatment. The aim of the present study was to examine the percentages of proteinuria in patients with metastatic colorectal cancer after the administration of bevacizumab. The correlation between the degree of proteinuria and changes in the number of platelets and concentration of haemoglobin in patients, as well as in relation to the age (< 60 i ≥ 60) and gender of the patients, was examined.
The study group of respondents included 20 patients with metastatic colorectal cancer (9 men and 11 women) ranging in age from 43 to 73 years. Proteinuria was tested using “Laboquick” test strips. The levels of platelets and haemoglobin were measured using an autoanalyser, the type Cell Dyn 3700 – Abbott, according to the protocol prescribed by The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).
Statistically significant differences were recorded for the platelet measurements before and after therapy in the overall group of respondents (p= 0.025). Statistically significant decreases in platelet counts and increases in haemoglobin concentrations were also noted in women (Plt: p=0.0036; Hb: p=0.0286) and in patients < 60 years old (Plt: p=0.0270; Hb: p=0.0553). No significant differences were identified in men or in patients ≥ 60 years of age. Proteinuria was detected in one case in which demonstrating an increase in only the recorded number of platelets and a decrease in the level of haemoglobin.
Platelets and haemoglobin may serve as prognostic biomarkers of the risk of proteinuria. Based on the initial values of these parameters, we can predict the target group, in terms of gender and age, that may obtain the most benefit from bevacizumab therapy.
Vitamin C In Neuropsychiatry
Authors: Pavlović Dragan M. , Markišić Merdin Š. , Pavlović Aleksandra M. 
Published: January 2016

Abstract
Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain.
Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer’s disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C.
Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart
Authors: Plecevic Sasa , Pechanova Olga , Barta Andrej , Vranic Aleksandra , Jeremic Jovana , Arsenijevic Ljiljana , Jeremic Nevena , Jakovljevic Vladimir , Jevdjevic Maja , Stanojevic Dejan 
Published: January 2016

Abstract
Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH2O). Markers of oxidative stress (NO2
−, TBARS, H2O2 and O2
−) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO2
−) and hydrogen peroxide (H2O2) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers.
Plasma Homocysteine Concentrations In Patients With Rheumatoid Arthritis
Authors: Vasiljevic Dragan , Tomic-Lucic Aleksandra , Zivanovic Sandra , Milosavljevic Mirjana , Radovanovic Snezana , Andjelkovic Nebojsa , Djuric Dragan , Veselinovic Mirjana 
Published: January 2016

Abstract
In this study, we investigated the concentration of serum homocysteine (Hcy) in patients with rheumatoid arthritis (RA) compared with the control group and the connection between homocysteine and parameters of inflammation and disease activity. Sixty RA patients and 20 healthy controls were included in the study, and clinical examination and investigation were performed during which disease activity was assessed. Peripheral blood samples were used for all of the assays. Levels of Hcy were 33% higher in the RA patients than in the control subjects (mean +/− SD 11.79±3.72 μmol/L versus 8.90±1.38 μmol/L; p< 0.01). A significant correlation was found between parameters of inflammation (C-reactive protein) and homocysteine in patients (r=0.322, p=0.012). Patients with high disease activity had a significantly greater increase in homocysteine (p<0.05). An increase in plasma homocysteine in RA patients is related to the parameters of inflammation and disease activity. Elevated Hcy levels occur commonly in patients with RA and may explain some of the increased cardiovascular mortality seen in RA patients.
Anthropometric Characteristics, Nutritional Status And Dietary Habits In A College Population
Authors: Miljanovic Gora , Mutavdzic Beba , Marjanovic Milan , Zivaljevic Zvonko , Janosevic Miljojko , Masic Sinisa , Pelva Denis 
Published: January 2016

Abstract
The college student population is prone to irregular food intake and the excessive intake of carbohydrates and snacks. The aim of this study is to investigate the relationships among anthropometric characteristics, dietary habits and nutritional knowledge in female students attending a healthcare college.
Our investigation enrolled 100 college students at the High Health School of Professional Studies in Belgrade, 19-30 years old, who underwent anthropometric measurements and an investigation by questionnaire of their nutritional knowledge as well as recorded a 7-day food diary. The results were interpreted in relation to their location of nutritional intake.
The majority of students showed good nutritional knowledge. Of the total population, 83% were of normal weight, 11% were overweight, and 5% were underweight. The average Body Mass Index values, as well as body fat percentage, were similar regardless of the type of eating location, but all overweight and obese students were recorded in the groups that ate in the student dining facility and that prepared food and ate by themselves. Students who ate with their families ate significantly fewer fats and proteins but significantly more carbohydrates compared to students in the other two groups. Higher fat intake and snack consumption are significantly related to an increased percentage of body fat. Fruit intake is inversely related to body fat percentage.
Despite the relatively low prevalence of overweight, obesity, and underweight in the investigated population, the given results indicate that students may benefit from health promotion activities, increased knowledge and improved eating habits. This is especially important considering that they are future health professionals.
Acute Urinary Tract Obstruction
Authors: Aleksic Djordje 
Published: January 2016

Abstract
The kidneys are paired organs with the primary function of helping to remove toxins from the body and regulate water balance. They are vital to survival. After urine is produced in the kidneys, it must pass into the bladder, where it can be stored before being eliminated from the body through the urethra. Urinary tract obstruction is a common problem encountered by urologists, primary care physicians, and emergency medicine physicians. Urine can become obstructed at any point in this pathway. There are three groups of urinary tract obstructions: 1) obstruction of the urinary tract lumen; 2) obstruction of the urinary tract wall; and 3) extrinsic obstruction, which can press on the urinary tract lumen. An obstruction can be present from birth or develop later in life. The most common causes of obstruction include stones, strictures, tumours, and bladder dysfunction. These obstructions may result in the hydronephrosis of one or both kidneys, which, if left untreated, may lead to the deterioration of renal function. The goal of an initial treatment of urinary tract obstruction is to remove the obstruction. Later, we treat the cause that led to the obstruction. The bottom line is that all efforts should be made to preserve kidney function to avoid the need for dialysis or renal transplantation.
Immunohistomorphometric Characteristics Of Pituitary GH Cells In Infant And Peripubertal Female Rats After Treatment With Estradiol Or Human Chorionic Gonadotropin
Authors: Ristic Natasa , Ajdzanovic Vladimir , Trifunovic Svetlana , Tanic Nasta , Bujisic Nada , Milosevic Verica 
Published: January 2016

AbstractThe effects of estradiol-dipropionate (EDP) or human chorionic gonadotropin (hCG) on immunohistomorphometric characteristics of pituitary GH cells in infant and peripubertal female rats were investigated. The first group of females received five injections of EDP (0.25 mg/kg b.w.) during the neonatal period of life, and was further divided into two subgroups which were sacrificed at the infantile period (17th day) or at the peripubertal period (38th day). The second group received two doses of hCG (50 IU/kg b.w.) on the 15th and 16th day of life in the first subgroup, and on the 36th and 37th days of life in the second subgroup, while they were sacrificed 24 h after the last treatment, respectively. The control females were injected with an equivalent volume of the vehicle and sacrificed according to the appropriate schedules as the hormone treated rats. EDP treatment decreased GH cell volume density in infant and peripubertal females, by 38% and 76% (p<0.05) respectively, in comparison with the controls. The number of GH cells per mm2 in infantile and peripubertal period was decreased in EDP treated animals by 26% and 53% (p<0.05) respectively, compared to the controls. Also, upon EDP treatment in both periods, GH cells were diminished in size and less intensely immunolabelled than in the control groups. The morphometric parameters in animals treated with hCG were insignificantly changed in both analyzed periods, in comparison with the controls. Unlike hCG, EDP manifested clear inhibitory effects on the immunohistomorphometric characteristics of GH cells in examined female rats.
Mobilität und Standortwahl höherqualifizierter Existenzgründer in Deutschland und den Niederlanden
Authors: Janssen Manfred 
Published: January 2016

Abstract
The rise of new enterprises is associated with job growth and regional economic change. Due to a lack of adequate theories, however, little is known about the job location of graduate- entrepreneurs. Primary data from surveys in Germany and the Netherlands show a strong correspondence between the brain drain of employees and entrepreneurs. Logit-models are applied to explain the locational distribution of entrepreneurs by using labour market mobility approaches for employees.
Regionale Kompetenzzyklen – Zur Bedeutung von Produktlebenszyklus- und Clusteransätzen im regionalen Kontext
Authors: Tichy Gunther 
Published: January 2016

Abstract
Modelling the path of the regional product cycle and adding dynamic and stochastic aspects suggests the likelihood of multiple equilibria; bunches of divergent paths of the product cycle may result, depending on starting conditions and parameter size. Narrow clusters of traditional products based on localisation economies, for instance, are quite likely to age, following the traditional bell-shaped path: accelerating expansion, congestion and Saturation, sclerosis and decline. Clusters based on urbanisation economies, on the other hand, face a much lower probability of aging, and if they do, they tend to pass the stages more slowly; their greater adaptability results from the higher information density of the region. Regions characterised by coexistence of several clusters are the ones most likely to avoid aging. Neither theoretical arguments nor historical examples, however, can be found in favour of a regional cycle in literal sense: a new product cycle following the declining one necessarily or at least with some likelihood.
Environmental problems and environmental governance in the context of dynamic economic growth – the case of China
Authors: Richerzhagen Carmen , Scholz Imme 
Published: January 2016

Abstract
The fast growing anchor countries have become key players in mitigating global environmental change. China is a very particular anchor country. The size, scope and quality of the environmental degradation associated with its dramatic economic growth is much larger than that of all the other anchor countries. Despite being regarded as an all-embracing emerging superpower, China is a very heterogeneous country regarding its economic, social and environmental structure. Regional differences require an effective response. However, China’s environmental governance system is characterized by a number of weaknesses, which impede the implementation of targets and objectives set by policies and laws. The most significant weakness refers to the insufficient institutional framework for horizontal and vertical policy coordination. Good environmental governance requires measures that address these deficiencies. Furthermore, the diffusion of public information on the costs of environmental degradation and the rule of law have to be promoted as complementary measures.
Strategies of using social proximity and organizational proximity in product innovation
Authors: Fu Wenying , Schiller Daniel , Diez Javier Revilla 
Published: January 2016

Abstract
In this paper we investigate how the innovation behavior of firms to capitalize on social proximity with independent firms and organizational proximity with parent companies and foreign customers contributes to innovation in the Pearl River Delta (PRD), China. While traditional views often hold that Chinese firms rely heavily on organizational proximity with parent companies and foreign customers to gain access to knowledge, we aim for insights into whether localized learning mechanisms based on informal social relations have emerged in the region after more than thirty years of industrialization. Based on a questionnaire survey of 359 innovative electronics firms, this paper demonstrates that firms which use social proximity to foster innovation are emerging in the PRD, and that it is mainly applied by domestic firms as a ‘spying device’ to catch up with the latest technology and market preference in order to trigger new product ideas. Nevertheless, the achievements of product innovation performance made by applying social proximity in interactive learning are fairly small, which underpins the instability of the trust-based interactive learning between firms in the region. The results of the paper provide insight into the development stage of the regional innovation system in the Pearl River Delta, calling upon an effective governance infrastructure to be put in place to stabilize interactive learning on the local scale.