bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective validation of an automated chemiluminescence-based assay of renin and aldosterone for the work-up of arterial hypertension
Authors: Rossi Gian Paolo , Ceolotto Giulio , Rossitto Giacomo , Seccia Teresa Maria , Maiolino Giuseppe , Berton Chiara , Basso Daniela , Plebani Mario 
Published: January 2016

AbstractBackground:The availability of simple and accurate assays of plasma active renin (DRC) and aldosterone concentration (PAC) can improve the detection of secondary forms of arterial hypertension. Thus, we investigated the performance of an automated chemiluminescent assay for DRC and PAC in referred hypertensive patients.Methods:We prospectively recruited 260 consecutive hypertensive patients referred to an ESH Center for Hypertension. After exclusion of six protocol violations, 254 patients were analyzed: 67.3% had primary hypertension, 17.3% an aldosterone producing adenoma (APA), 11.4% idiopathic hyperaldosteronism (IHA), 2.4% renovascular hypertension (RVH), 0.8% familial hyperaldosteronism type 1 (FH-1), 0.4% apparent mineralocorticoid excess (AME), 0.4% a renin-producing tumor, and 3.9% were adrenalectomized APA patients. Bland-Altman plots and Deming regression were used to analyze results. The diagnostic accuracy (area under the curve, AUC of the ROC) of the DRC-based aldosterone-renin ratio (ARRCL) was compared with that of the PRA-based ARR (ARRRIA) using as reference the conclusive diagnosis of APA.Results:At Bland-Altman plot, the DRC and PAC assay showed no bias as compared to the PRA and PAC assay. A tight relation was found between the DRC and the PRA values (concordance correlation coefficient=0.92, p<0.0001) and the PAC values measured with radioimmunoassay and chemiluminescence (concordance correlation coefficient=0.93, p<0.001). For APA identification the AUC of the ARRCLwas higher than that of the ARRRIA[0.974 (95% CI 0.940–0.991) vs. 0.894 (95% CI 0.841–0.933), p=0.02].Conclusions:This rapid automated chemiluminescent DRC/PAC assay performed better than validated PRA/PAC radioimmunoassays for the identification of APA in referred hypertensive patients.
The Asaeda–Haagerup fusion categories
Authors: Grossman Pinhas , Izumi Masaki , Snyder Noah 
Published: January 2016

Abstract
The classification of subfactors of small index revealed several new subfactors. The first subfactor above index 4, the Haagerup subfactor, is increasingly well understood and appears to lie in a (discrete) infinite family of subfactors where the

ℤ

\mathbb{Z}

/3

ℤ

\mathbb{Z}

symmetry is replaced by other finite abelian groups. The goal of this paper is to give a similarly good description of the Asaeda–Haagerup subfactor which emerged from our study of its Brauer–Picard groupoid. More specifically, we construct a new subfactor

𝒮

{\mathcal{S}}

which is a

ℤ

\mathbb{Z}

/4

ℤ

\mathbb{Z}

×

\times

ℤ

\mathbb{Z}

/2

ℤ

\mathbb{Z}

analogue of the Haagerup subfactor and we show that the even parts of the Asaeda–Haagerup subfactor are higher Morita equivalent to an orbifold quotient of

𝒮

{\mathcal{S}}

. This gives a new construction of the Asaeda–Haagerup subfactor which is much more symmetric and easier to work with than the original construction. As a consequence, we can settle many open questions about the Asaeda–Haagerup subfactor: calculating its Drinfeld center, classifying all extensions of the Asaeda–Haagerup fusion categories, finding the full higher Morita equivalence class of the Asaeda–Haagerup fusion categories, and finding intermediate subfactor lattices for subfactors coming from the Asaeda–Haagerup categories. The details of the applications will be given in subsequent papers.
Synthesis and Characterization of Cadmium Sulfide Nanoparticles via a Simple Thermal Decompose Method
Authors: Seyghalkar Hamideh , Sabet Mohammad , Salavati-Niasari Masoud 
Published: January 2016

AbstractIn this work, cadmium sulfide (CdS) nanoparticles were synthesized from a new Cd-octanoate complex via a simple thermal decompose method. The crystallinity of the product was obtained from X-ray diffraction (XRD) pattern. The morphology and product size were analyzed via scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Also Fourier transform infrared (FT-IR) spectroscopy was used to investigate the CdS surface purity. Finally, the optical properties of the product were obtained from photoluminescence (PL) spectroscopy.
Thermoeconomic Optimization of a Combined Heating and Humidification Coil for HVAC Systems
Authors: Teodoros Liliana , Andresen Bjarne 
Published: January 2016

AbstractThe total cost of ownership is calculated for a combined heating and humidification coil of an air-handling unit taking into account investment and operation costs simultaneously. This total cost represents the optimization function for which the minimum is sought. The parameters for the cost dependencies are the physical dimensions of the coil: length, width and height. The term “coil” is used generically since in this setup it generates heating as well as humidification in a single unit. The first part of the paper deals with the constructive optimization and finds the relationship between the dimensions for a minimum cost. The second part of the paper takes the results of the constructive optimization further and, based on the data derived in our previous papers, analyzes the minimum total cost for the humidification coil while balancing the amount of water used to humidify the air and modify its temperature.
Performance Evaluation of Passive Optical Network Using Different Modulation Formats
Authors: Kaur Ravneet , Dewra Sanjeev 
Published: January 2016

AbstractIn this paper, the performance of passive optical network is analyzed and compared for different modulation formats such as non-return to zero (NRZ), return to zero (RZ) at 2.5 Gb/s bit rate with 16 optical network units. This system is investigated in terms of quality (Q)-factor, optical received power and eye height at different transmission distances. NRZ achieves maximum transmission distance up to 48 km having Q-factor of 6.18 and RZ achieves the maximum transmission distance up to 41 km having Q-factor of 6.21. Furthermore, it is found that NRZ modulation format is more superior and covers more distance as compared to RZ modulation format.
„Io sono Colui che ti guarisce“. Sanare e salvare nelle più antiche fasi della storia di Israele
Authors: Camassa Giorgio 
Published: January 2016

Riassunto
Se si raffronta l’antico Israele con le culture circonvicine, colpisce senza ombra di dubbio la costante affermazione per cui salute e salvezza possono venire esclusivamente da Yahweh, mentre altrove si fa affidamento su qualche divinità del pantheon. In proposito, non disponiamo soltanto dei materiali rifluiti nei libri di quello che è per noi l’„Antico Testamento“. Un corpus, con ogni probabilità destinato ad accrescersi, di iscrizioni risalenti ai secoli iniziali del I millennio a. C. conferma quanto emerge dalle testimonianze bibliche, di per sé altamente problematiche, ma non perciò riconducibili sempre a un orizzonte relativamente tardo. Un ulteriore elemento a disposizione è l’onomastica personale teoforica: l’esame di questi nomi si rivela altamente remunerativo e fornisce indicazioni più di una volta preziose.
Ios. bell. Iud. 2, 366–387 e CIL XIV, 3608: note esegetiche e cronologiche
Authors: Colombo Maurizio 
Published: January 2016

Riassunto
Flavio Giuseppe mette in bocca ad Agrippa II un lungo discorso, con cui il re tenta di dissuadere i suoi connazionali dalla rivolta contro l’impero romano; un argomento cruciale consiste nella forza militare dei Romani, alla quale lo storiografo dedica un catalogo concentrato sulla dislocazione delle legioni. La data dichiarata del discorso è il 66 d. C. Emil Ritterling contestò tale ambientazione e datò le informazioni militari del fittizio discorso sotto il regno di Vespasiano; alcuni studiosi hanno pienamente accettato questa ricostruzione, ma altri danno ancora credito alla data narrativa. Qui si dimostra che Flavio Giuseppe, componendo il catalogo delle legioni, riportò diligentemente la genuina dislocazione delle truppe romane poco prima dello scoppio della ribellione giudaica; i pochi anacronismi non vanno oltre il 69 d. C. Questa conclusione permette di gettare nuova luce sulla cronologia e sulla portata delle imprese di Tiberius Plautius Siluanus Aelianus.
Kaiser Julian, An den Senat und das Volk der Athener. Einleitung, Übersetzung und Kommentar
Authors: Stöcklin-Kaldewey Sara 
Published: January 2016

Zusammenfassung
Der erstmals in deutscher Übersetzung vorliegende Brief an den Senat und das Volk der Athener, in dem der spätere Kaiser Julian dem Vorwurf der Usurpation entgegentritt, zeichnet sich durch irritierende Offenheit aus. Kein anderes Werk des letzten Vertreters der konstantinischen Dynastie kennt einen vergleichbaren Tonfall. In drastischen Ausdrücken schildert Julian, wie er von Constantius II. und dessen Hofstaat trotz seiner militärischen Erfolge verachtet und hintergangen wurde. Es resultiert ein in vielerlei Hinsicht interessanter Bericht, dessen Potential als historische Quelle bei weitem noch nicht ausgeschöpft wurde.
Urethral stone of unexpected size: case report and short literature review
Authors: Kaczmarek Krystian , Gołąb Adam , Soczawa Michał , Słojewski Marcin 
Published: January 2016

Abstract
Urolithiasis is a well-known disease. Stones can form in all parts of the urinary tract. Diagnosis and treatment usually do not create clinical problems. However from time to time in daily practice doctors are confronted with casuistic cases. Here, we report a 54-year-old man with a large stone localized to the urethra. Because of the size of the stone, confirmed on radiography, and the presence of a cutaneous fistula, open surgery was performed. Due to urethral stricture, the patient required a second stage of reconstructive surgery. This case emphasizes that unusual presentation of urolithiasis may occur, and different surgical approaches as well as other surgical manipulations in such cases must be considered.
Crystal structure of the catena-poly[bis(1H-imidazole-κN)-(μ2-furan-2,5-dicarboxylato-κ2
O
1:O
4)manganese(II)]monohydrate, C12H12MnN4O6
Authors: Wang Yuan-Rui , Gao Wen-Yuan , Li Ya-Feng 
Published: January 2016

Abstract
C12H12MnN4O6, monoclinic, P21/c (no. 14), a = 8.1583(16) Å, b = 16.525(3) Å, c = 13.134(3) Å, β = 117.96(3)°, V = 1564.0(7) Å3, 4 = 2, R
gt
(F) = 0.0503, wR
ref
(F
2
) = 0.1579, T = 293 K.
ST2 Deficiency Ameliorates High Fat Diet-Induced Liver Steatosis In BALB/c Mice
Authors: Jovicic Nemanja , Jeftic Ilija , Kovacevic Marina Miletic , Tanaskovic Irena , Arsenijevic Nebojsa , Lukic Miodrag L. , Pejnovic Nada 
Published: January 2016

ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity, but the molecular mechanisms of liver steatosis and its progression to non-alcoholic steatohepatitis and fibrosis are incompletely understood. Immune reactivity plays an important role in the pathogenesis of NAFLD. The IL-33/ST2 axis has a protective role in adiposity and atherosclerosis, but its role in obesity-associated metabolic disorders requires further clarification. To investigate the unresolved role of IL-33/ST2 signalling in NAFLD, we used ST2-deficient (ST2-/-) and wild type (WT) BALB/c mice maintained on a high-fat diet (HFD) for 24 weeks. HFD-fed ST2-/- mice exhibited increased weight gain, visceral adipose tissue weight and triglyceridaemia and decreased liver weight compared with diet-matched WT mice. Compared with WT mice on an HFD, ST2 deletion significantly reduced hepatic steatosis, liver inflammation and fibrosis and downregulated the expression of genes related to lipid metabolism in the liver. The frequency of innate immune cells in the liver, including CD68+ macrophages and CD11c+ dendritic cells, was lower in HFD-fed ST2-/- mice, accompanied by lower TNFα serum levels compared with diet-matched WT mice. Less collagen deposition in the livers of ST2-/- mice on an HFD was associated with lower numbers of profibrotic CD11b+Ly6clow monocytes and CD4+IL-17+ T cells in the liver, lower hepatic gene expression of procollagen, IL-33 and IL-13, and lower serum levels of IL-33 and IL-13 compared with diet-matched WT mice.
Our findings suggest that the IL-33/ST2 axis may have a complex role in obesity-associated metabolic disorders. Although it is protective in HFD-induced adiposity, the IL-33/ST2 pathway promotes hepatic steatosis, inflammation and fibrosis.
Enhancement Of Dermal Fibroblast Isolation Method
Authors: Zaric Milan , Nikolic Ivana , Zelen Ivanka , Mitrovic Marina , Milosavljevic Zoran 
Published: January 2016

ABSTRACT
Cultivated fibroblasts have been widely used in a large number of in vitro studies. Although they readily proliferate under cell culture conditions, improvements in methods for their isolation are necessary. Here, we present our modified enzyme digestion method and compare its efficiency with commonly used techniques.
Three foreskin samples from young, middle-aged and old donors were used. The classical explant, standard enzyme digestion method with collagenase and our improved enzyme digestion method were compared for efficiency of fibroblast isolation and the time needed to achieve 95% confluence in a 30-mm Petri dish.
The explant method was the slowest to achieve fibroblast confluence, especially with the tissues from the older donors (up to 23 days). With the standard enzyme digestion method, the skin tissue was partially digested, but the fibroblasts reached confluence much faster (the younger donor cells needed approximately 7 days to reach confluence). Our modified “mixed” enzyme digestion method was the fastest (the fibroblasts from the younger donors needed up to 5 days to reach confluence).
For studies requiring the primary isolation and cultivation of dermal fibroblasts, the best method to achieve this goal is the tissue digestion method with the multiple enzyme solution.
CYP3A5 Polymorphism In Serbian Paediatric Epileptic Patients On Carbamazepine Treatment
Authors: Milovanovic Dragana Dragas , Radosavljevic Ivan , Radovanovic Marija , Milovanovic Jasmina R. , Obradovic Slobodan , Jankovic Slobodan , Milovanovic Dragan , Djordjevic Natasa 
Published: January 2016

Abstract
Carbamazepine exhibits significant inter-individual variability in its efficacy and safety, which leads to unpredictable therapy outcomes for the majority of patients. Although its complex biotransformation depends on CYP3A5 activity, evidence of association between carbamazepine treatment outcomes and CYP3A5 functional variations remains inconclusive. The aim of the present study was to investigate the distribution of two of the functionally important CYP3A5 variants *2 and *3 as well as their effects on carbamazepine dose requirements, plasma concentrations and clearance in a Serbian population. The study involved 40 paediatric epileptic patients on steady-state carbamazepine treatment. Genotyping was conducted using the PCR-RFLP method, and carbamazepine plasma concentrations were determined using the HPLC method. CYP3A5*2 and *3 polymorphisms were found at frequencies of 0.0% and 97.5%, respectively, which corresponds well to previously published data for Caucasians. No differences in CYP3A5*3 allele frequencies were detected among epileptic patients in comparison to healthy volunteers within similar ethnic populations (p>0.08), indicating that CYP3A5 polymorphism does not represent a risk factor for epilepsy development. There was an observed tendency towards lower dosage requirements (mean±SD: 15.06±4.45 mg/kg vs. 18.74±5.55 mg/kg; p=0.26), higher plasma concentrations (mean±SD: 0.45±0.13 mg/kg vs. 0.38±0.03 mg/kg; p=0.47) and lower clearance (mean±SD: 0.14±0.05 mg/kg vs. 0.15±0.01 mg/kg; p=0.79) of carbamazepine in homozygous carriers of CYP3A5*3/*3 compared to heterozygous CYP3A5*1A/*3 Serbians. Because these genotype groups did not differ significantly in terms of their carbamazepine pharmacokinetics parameters, the proposed effects of CYP3A5*3 on carbamazepine metabolism could not be confirmed.
Risk Factors For Development Of Acute Necrotizing Pancreatitis
Authors: Stojanovic Bojan , Spasic Marko , Radosavljevic Ivan , Canovic Dragan , Radovanovic Dragce , Praznik Ivan , Prodanovic Nikola , Milojevic Andjela , Jelic Ivana , Babic Zivan , Artinovic Viktorija , Grubor Iva , Nikolic Ljiljana , Vucicevic Ksenija , Miljkovic Jelena , Divjak Ana , Stefanovic Srdjan , Jankovic Slobodan 
Published: January 2016

Abstract
Acute necrotizing pancreatitis (ANP) is a severe form of acute pancreatitis that is associated with high morbidity and mortality. Thus, an adequate initial treatment of patients who present with acute pancreatitis (AP) based on correct interpretation of early detected laboratory and clinical abnormalities may have a significant positive impact on the disease course.
The aim of the study was to determine patient- and initial treatment-related risk factors for the development of acute necrotizing pancreatitis.
For the purpose of this study a case-control design was chosen, including adult patients treated for AP in the surgical Intensive Care Unit (sICU) of Clinical Center of Kragujevac, from January 2006 to January 2011. The cases (n=63) were patients who developed ANP, while the controls (n=63) were patients with AP without the presence of pancreatic necrosis. The controls were randomly selected from a study sample after matching with the cases by age and sex.
Significant association with the development of ANP was found for the presence of comorbidity (adjusted OR 6.614 95%CI 1.185-36.963), and the use of somatostatin (adjusted OR 7.460, 95%CI 1.162-47.833) and furosemide (adjusted OR 2710.57, 95%CI 1.996-56.035) started immediately upon admission to the sICU.
This study suggests that comorbidities, particularly the presence of serious cardio-vascular disease, can increase the risk for development of acute necrotizing pancreatitis. The probability for the development of ANP could be reduced by the avoidance of the initial use of loop diuretics and somatostatin.
Discoid Lateral Meniscus Incidence During Knee Arthroscopy
Authors: Glisic Miodrag , Blagojevic Zoran , Ristic Branko , Stevanovic Vladan , Matic Aleksandar , Jovanovic Zelimir 
Published: January 2016

Abstract
Discoid meniscus is a morphological anomaly of the lateral meniscus that appears in 1–5% of meniscectomies. A precise diagnosis remains difficult to make, and many dilemmas hinder effective treatment.
To evaluate the incidence of discoid meniscus in patients who underwent knee arthroscopy, as well as the discoid meniscus type, follow-up problems, combined knee lesions, and postoperative results.
This retrospective study included 1357 patients who received knee arthroscopy during the period between January 2007 and December 2013. We analysed the discoid meniscus incidence, sex distribution, type distribution (Monllau classification), noted preoperative symptomatology, rupture incidence and type (O’Connor classification), anomaly presence and other intra-articular lesion correlations. The IKDC score was used to evaluate the operative treatment results.
The DLM incidence was 1.03%. The most common type of discoid meniscus was complete 5 (35.71 %). The dominant symptom was pain, which was reported by 12 (85.71%) patients. Eleven (78.57 %) patients exhibited ruptures, and the most common type was horizontal, which was reported in 4 (36.36%) cases. The number of ruptures was significantly higher in patients older than 18 (9 patients; 90%), compared to those younger than 18 (2 patients; 40%). Operative treatment resulted in an improvement for all patients in terms of subjective symptom reduction.
The incidence of DLM in our study was 1.03%, and the dominant symptom was pain in the knee (85.71%). The most common lesion of the meniscus was a horizontal split, primarily in patients older than 18 years. Patients also presented with joint intra-articular lesions; the most common type was ACL rupture. In all patients, an improved postoperative IKDC score was reported.
The Analysis Of Antibiotic Consumption And Bacterial Resistance As An Indicator Of Their Proper Use At The Urology Department In The Health Centre “Studenica” Kraljevo
Authors: Bukonjić Andriana , Stefanović Srđan 
Published: January 2016

Abstract
The objective of the study was to analyze antibiotic consumption and determine bacterial resistance rates as an indicator of the rational utilization of this drug group at the urology department in the Health Centre “Studenica” Kraljevo.
Over a two-year period, the average antibiotic consumption was 104.55 DDD/100BD. Of the total financial assets used for medical treatment, the antibiotic group JO1 had a share of 49.52% in 2011 and 47.53% in 2012. Antibacterial drugs from a group of β-lactamic antibiotics were consumed most commonly, at 54.02% (2011) and 43.44% (2012). First-generation cephalosporins, quinolones and aminoglycosides were the most frequently used drug groups, while cephalexin was the antibiotic with the highest individual consumption. E. coli was the most frequently isolated bacterium in 2011, while in 2012, Klebsiella pneumoniae was the most frequently isolated bacterium. The total bacterial resistance both in 2011 and 2012 was above 50%. Gram-negative bacteria showed a higher resistance rate (2011, 59.3%; 2012, 58.9%) than Gram-positive bacteria (2011, 44.4%; 2012, 40.6%). Klebsiella pneumoniae was the bacterium with the highest resistance (75.3%) in 2011, while in 2012, there was a resistance increase in Pseudomonas aeruginosa (71.4%), especially to carbapenems. A correlation was determined between the consumption of individual antibiotics and bacterial strain resistance in 2011 (r=0.433, p=0.044) and in 2012 (r=0.478, p=0.024).
The high resistance rate shown in the bacterial strains, which was correlated with antibiotic consumption, as well as the great financial assets used for this group of drugs suggest the necessity for the rationalization of their utilization. Empirical therapy with Gram-negative bacteria should be based on carbapenems utilization, except with Pseudomonas aeruginosa, where piperacillin/tazobactam should be used.
Lack Of PRSS1 And SPINK1 Polymorphisms In Serbian Acute Pancreatitis Patients
Authors: Radosavljevic Ivan , Milojevic Andjela , Miljkovic Jelena , Divjak Ana , Jelic Ivana , Artinovic Viktorija , Spasic Marko , Stojanovic Bojan , Canovic Predrag , Jankovic Slobodan , Djordjevic Natasa 
Published: January 2016

Abstract
Acute pancreatitis represents an acute nonbacterial inflammation of the pancreas caused by a premature and ectopic activation of pancreatic digestive enzymes. Two of the most important genes in pancreatic autodigestion, PRSS1 and SPINK1, were implicated in the earliest discoveries of the genetic background of pancreatitis. However, the distribution of their variations displays interethnic variability, which could significantly affect the magnitude of their proposed effects on this disease worldwide. The aim of the present study was to investigate the distribution of the most important functional variations of PRSS1 (86A>T and 365G>A) and SPINK1 (101A>G), and their influence on the clinical course of acute pancreatitis in Serbian patients. The study enrolled 81 subjects, the severity of disease course was determined using the Atlanta Classification system, and the genotyping was conducted using a PCR-RFLP method. PRSS1 86A>T and 365G>A SNPs were not observed in the study population, while SPINK1 101A>G was present with the frequency of 0.62% (95% CI: 0.00, 3.83%). Due to extremely low frequencies or absences of examined variations, the proposed effect of these SNPs on the severity of acute pancreatitis could not be confirmed. The results do not support routine genotyping of either PRSS1 or SPINK1 in Serbs.