bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH TRANSFORMATIONAL LEADERSHIP, WORK ENVIRONMENT, ORGANIZATIONAL CULTURE TERHADAP EMPLOYEE PERFORMANCE DENGAN JOB SATISFACTION SEBAGAI VARIABEL MEDIASI
Authors: Asri Dhita Hafizha Asri , Nova Nova Elisa 
Published: September 2024

Rendahnya kinerja karyawan di 5 perusahaan terpilih dengan jumlah KBLI terbanyak di Kota Batam diindikasikan dengan rendahnya pertumbuhan industri pengolahan manufaktur. Penurunan pertumbuhan industri manufaktur disebabkan oleh kinerja karyawan yang semakin menurun. Fenomena tersebut mendorong penelusuran lebih lanjut untuk mengungkap mengapa kinerja karyawan tergolong rendah. Data penelitian dikumpulkan melalui metode kuantitatif, dengan menggunakan teknik purposive sampling untuk menentukan sampel penelitian. Teknik pengambilan sampel menggunakan Hair et al. (2016) dengan total responden yang mengisi adalah sebanyak 301 dengan jumlah pernyataan kuesioner sebanyak 26. Data penelitian ini dikumpulkan secara primer melalui penyebaran kuesioner online menggunakan Google Form. Data yang terkumpul kemudian diolah menggunakan program SPSS dan SPLS. Hasil yang didapat adalah Transformational Leadership, Organizational Culture, dan Work Environment mempengaruhi Employee Performance, dan Job Satisfaction berpengaruh sebagai variabel mediasi. Implikasinya adalah perusahaan dapat meningkatkan gaya kepemimpinan transformasional, mengembangkan budaya baik dalam perusahaan, dan menciptakan lingkungan kerja yang baik yang dapat mempengaruhi kinerja karyawan dalam perusahaan.
Effect of the Linker and Substituents on the Ionic Conductivity of Borate Single-Ion Polymers for Lithium Batteries
Authors: Vauthier Soline , Cotte Stéphane , Castro Laurent , Guéguen Aurélie , Casado Nerea , Mecerreyes David , Guzmán-Gonzalez Gregorio 
Published: September 2024

Polymer electrolytes with high ionic conductivity are actively searched for their application as solid electrolytes in lithium batteries. Here, we show new borate single lithium-ion conducting polymers with high ionic conductivity and lithium transference number values. For this purpose, eight new methacrylic lithium borate polymers were synthesized and characterized with varying chemical compositions focusing on the linker between the polymer chain and the pendant borate ionic group and its substituents. The polymers with the optimum ethoxy linker and fluorinated pendant groups show a low Tg value and the highest ionic conductivity value of 1.29×10-4 S.cm-1 at 60 °C. This value is among the highest ionic conductivity reported for a single lithium-ion conducting homopolymer. These polymers show a high lithium transference number (between 0.88 and 0.96) and electrochemical stability close to 4.2 V vs Li+/Li, making them promising candidates for application as solid electrolytes in lithium batteries.

Resumen. Se buscan activamente electrolitos poliméricos con alta conductividad iónica para su aplicación como electrolitos sólidos en baterías de litio. Aquí, mostramos nuevos polímeros conductores de iones de litio de borato simples con valores muy altos de conductividad iónica y número de transferencia de litio. Para ello, se sintetizaron y caracterizaron ocho nuevos polímeros metacrílicos de borato de litio con composiciones químicas variables centradas en el enlazador entre la cadena polimérica y el grupo iónico borato colgante y sus sustituyentes. Los polímeros con el enlazador etoxi óptimo y los grupos colgantes fluorados muestran un valor Tg bajo y un valor superior de conductividad iónica 1,29×10-4 Scm-1 a 60 °C. Este valor es uno de los más altos de conductividad iónica a 60 °C. Este valor es uno de los valores más altos de conductividad iónica a 60 °C. Este valor es uno de los más altos valores de conductividad iónica registrados para un solo homopolímero conductor de iones de litio. Estos polímeros muestran un elevado número de transferencia de litio (entre 0.88 y 0.96), y una estabilidad electroquímica cercana a 4.2 V vs Li+/Li que los convierten en candidatos prometedores para su aplicación como electrolitos sólidos en baterías de litio.
Design and Synthesis of Barbiturates and Hydantoins with Multitarget Antidiabetic Effect☆
Authors: Juárez-Cruz Samantha , Estrada-Soto Samuel , Colin-Lozano Blanca , Marquina-Rodriguez Hugo , Delgado-Aguilar Thalía , Martínez-Conde Carlos , Gutiérrez-Hernández Abraham , Hernández-Núñez Emanuel , Giacoman-Martínez Abraham , Almanza-Pérez Julio Cesar , Navarrete-Vazquez Gabriel 
Published: September 2024

☆ Taking in part of the Master in Pharmacy thesis of S. Juárez-Cruz
In current work, we prepared a series of ten 4-aryloxy-5-benzylidenebarbiturates and hydantoins as 1,3-thiazolidine-2,4-dione bioisosteres. An in silico pharmacological consensus analysis (PHACA) was conducted to assess the pharmacokinetic, pharmacodynamics, biopharmaceutical, and toxicological properties of compounds 1-10. The goal was to identify computationally safe hits using a color-coded system resembling a traffic light. The compounds identified as safe computational hits through PHACA were 1, 2, and 4 from the barbiturate series, which were then selected by in vitro assays targeting PPAR-γ, GPR40, and GLUT-4 gene expression. Additionally, these three compounds underwent in vivo evaluation through a glucose tolerance curve assay conducted on normoglycemic mice. Compounds 1 and 4 exhibited antihyperglycemic effects within the first thirty minutes post-administration. Molecular docking studies were conducted to clarify the dual effect and binding mode of compounds 1, 2 and 4 on PPAR-γ and GPR40. Compounds 1 and 4 exhibited robust in vitro and in vivo efficacy and could be considered as multitarget modulators with antidiabetic effect.

Resumen. En este trabajo se preparó una serie de diez 4-ariloxi-5-bencilidenobarbituratos e hidantoínas como bioisósteros de la 1,3-tiazolidina-2,4-diona. Se realizó un análisis de consenso farmacológico in silico (PHACA) para evaluar las propiedades farmacocinéticas, farmacodinámicas, biofarmacéuticas y toxicológicas de los compuestos 1-10. El objetivo era identificar hits computacionales seguros utilizando un sistema codificado por colores que se asemeja a un semáforo. Los compuestos identificados como hits computacionales seguros fueron 1, 2 y 4 de la serie de barbituratos, que se eligieron para ensayos in vitro dirigidos a la expresión génica de PPAR-γ, GPR40 y GLUT-4. Además, estos tres compuestos se sometieron a una evaluación in vivo mediante un ensayo de curva de tolerancia a la glucosa realizado en ratones normoglucémicos. Los compuestos 1 y 4 exhibieron efectos antihiperglucémicos dentro de los primeros treinta minutos posteriores a la administración. Se realizaron estudios de acoplamiento molecular para clarificar el efecto dual y el modo de unión de los compuestos 1, 2 y 4 en PPAR-γ y GPR40. Los compuestos 1 y 4 exhibieron una sólida eficacia in vitro e in vivo, por lo que pueden considerarse moduladores polifarmacológicos con efecto antidiabético.
Solar Thermochemistry Overview: An Approach to Solar Thermal Energy Storage and Hydrogen Production
Authors: Santamaria Padilla Adriana , Romero Paredes Rubio Hernando , Macías Juan Daniel , Berrío Sánchez José Miguel , Elizalde Galicia Ana Karina 
Published: September 2024

The solar thermochemistry laboratory of the Metropolitan Autonomous University was created in early 1982 to promote the development of solar technology in our country. A decade ago, the priority objective of designing thermal energy storage systems that allow moderating the effects of intermittent solar radiation was proposed. This not only allows us to reduce the consumption of fossil fuels but also contributes to the mitigation of global warming by reducing carbon dioxide emissions. This paper highlights the benefits of research as a driver for advancing solar thermal technology and research efforts to develop heat storage systems. The work includes an overview of current thermal energy storage methods and their future projection. This work reports research developed with mixtures based on strontium carbonate doped with five compounds. The objective was to reduce agglomeration and sintering problems while significantly increasing the effective conversion and energy storage density. The experimental results demonstrate that the SrCO3+CaCO3 and SrCO3+SnO2 mixtures present better performance and stability than others. Finally, this article emphasizes the potential benefits of research, such as advancing solar technology, reducing carbon emissions, providing cleaner energy, and collaborating to address energy poverty.

Resumen. El laboratorio de termoquímica solar de la Universidad Autónoma Metropolitana fue creado a principios de 1982 para impulsar el desarrollo de la tecnología solar en nuestro país. Hace una década se propuso como objetivo prioritario diseñar sistemas de almacenamiento de energía térmica que permitan moderar los efectos de la radiación solar intermitente. Esto no sólo nos permite reducir el consumo de combustibles fósiles, sino que también contribuye a la mitigación del calentamiento global al reducir las emisiones de dióxido de carbono. Este artículo aborda los beneficios de la investigación como motor para el avance de la tecnología solar térmica y los esfuerzos de investigación para desarrollar sistemas de almacenamiento de calor. El trabajo incluye una revisión general de los métodos actuales de almacenamiento de energía térmica y su proyección futura. Se reportan las investigaciones desarrolladas con mezclas a base de carbonato de estroncio dopado con cinco compuestos. El objetivo es reducir los problemas de aglomeración y sinterización, al mismo tiempo que aumentar significativamente la conversión efectiva y la densidad de almacenamiento de energía. Los resultados experimentales demuestran que las mezclas SrCO3+CaCO3 y SrCO3+SnO2 presentan mejor rendimiento y estabilidad que otras. Finalmente, este trabajo enfatiza los beneficios potenciales de la investigación, como el avance de la tecnología solar, la reducción de las emisiones de carbono, el suministro de energía más limpia y la colaboración para abordar la pobreza energética.
Air-Stable Triazole-Based Ru(II) Complexes Catalyzed Transfer Hydrogenation of Ketones and Aldehydes Using Ethanol as a Solvent and a Hydrogen Donor
Authors: Vega Sánchez Evelyn , Corona Sánchez Ricardo , Gutiérrez-Carrillo Atilano , Rincón-Guevara Mónica A. , González-Sebastián Lucero 
Published: September 2024

The synthesis and characterization of two air-stable ruthenium (II) complexes from readily available triazole-based ligands are described. Both ruthenium complexes, one bearing a bidentate ligand (C-1) and the other a tridentate ligand (C-2), were tested as catalysts in the transfer hydrogenation of ketones and aldehydes using ethanol as a sustainable hydrogen source under aerobic conditions. Notably, the C-2 complex displayed exceptional efficiency under relatively mild conditions, demonstrating a wide substrate tolerance encompassing both alkyl and aryl ketones, as well as aryl aldehydes. Furthermore, our findings highlight the potential of Ru(II) complexes as effective catalysts for the hydrogenation of carbonyl bonds using ethanol, representing a green and sustainable approach without the necessity for an inert gas.

Resumen. En este trabajo se describe la síntesis y caracterización de dos complejos de rutenio(II) estables al aire con ligantes basados en triazoles. En general, los triazoles pueden obtenerse fácilmente a través de reacciones simples utilizando reactivos comercialmente disponibles. Ambos complejos de rutenio, uno con un ligante bidentado (C-1) y el otro con un ligando tridentado (C-2), se probaron como catalizadores en reacciones de hidrogenación por transferencia de cetonas y aldehídos, utilizando etanol como fuente sostenible de hidrógeno en condiciones aeróbicas. En particular, el complejo C-2 mostró una eficiencia excepcional en condiciones relativamente suaves, demostrando una amplia tolerancia tanto con cetonas alquílicas como aromáticas, además de hidrogenar eficientemente aldehídos aromáticos. Estos resultados ponen de manifiesto el potencial de los complejos de Ru(II) como catalizadores eficaces para la hidrogenación de enlaces carbonilo utilizando etanol, lo que representa un enfoque ecológico y sostenible sin necesidad de un gas inerte.
Low-grade systemic inflammation in patients with long COVID: The role of imbalance of endotoxin-releasing systems and vasoconstrictor markers
Authors: Beloglazov V. A. , Dudchenko L. Sh. , Useinova R. Kh. , Yatskov I. A. , Solovyova E. A. , Andreeva G. N. 
Published: September 2024

Background. Currently, the pathophysiological mechanisms of acute damage to organs and systems caused by coronavirus infection have been studied quite fully, but the mechanisms underlying the clinical manifestations of long COVID have not yet been accurately described. The mechanisms of persistence of a number of symptoms in patients who have had COVID-19 and the role of systemic inflammation and endotoxemia markers in it remain a understudied aspect and a promising direction for further studying.The aim of the study. To assess the markers of systemic inflammation, endotoxin-releasing systems, intestinal permeability and endothelial dysfunction in patients with long COVID at the stage of health resort treatment.Methods. The study included 32 patients who had recovered from coronavirus infection and were undergoing health resort treatment in the pulmonology department of the I.M. Sechenov Academic Research Institute for Physical Therapy, Medical Climatology and Rehabilitation. We also selected a control group (n = 20). All patients underwent peripheral blood analysis to detect the levels of markers of systemic inflammation, endotoxin-releasing systems, intestinal permeability, endothelial dysfunction and vasoconstrictor agents: C-reactive protein (CRP), lipopolysaccharide-binding protein (LPB), tissue-type plasminogen activator (tPA), zonulin, bactericidal/ permeability-increasing protein (BPI), vasopressors of angiotensin 2 and endothelin (EDN1).Results. Patients who had recovered from coronavirus infection had a statistically significant increase in the levels of CRP (3.4 [2.56; 4.0] mg/l), LBP (18.46 [14.0; 25.5] ng/ml), tPA (0.07 [0.02; 0.32] ng/ml), angiotensin 2 (133.3 [63.0; 503.7] pg/ml) and a decrease in the level of BPI (1576 [276; 3588] pg/ml) (p < 0.05).Conclusion. A statistically significant increase in markers of systemic inflammation, endotoxinemia, and vasoconstrictor agents in patients with long COVID indicates an imbalance in endotoxin-binding and endotoxin-releasing systems in patients who have had coronavirus infection. Further study of the described markers is necessary to improve approaches to long-term personalized therapy for this category of patients.
Gut microbiota biodiversity indices as markers of hyperandrogenemia in women of reproductive age
Authors: Igumnov I. A. , Belkova N. L. , Atalyan A. V. , Klimenko E. S. , Sholokhov L. F. , Belenkaia L. V. , Samarina Ya. M. , Danusevich I. N. , Lazareva L. M. , Nadeliaeva Ia. G. , Suturina L. V. 
Published: September 2024

Introduction. Previously, it was shown that the “classic” phenotypes of polycystic ovarian syndrome (PCOS) are associated with significant decrease in gut microbiota alpha diversity as compared with healthy women.The aim of the study. To establish cut-off points for alpha diversity indices, significant in polycystic ovarian syndrome with hyperandrogenism.Material and methods. The manuscript presents a sub-study of Eastern Siberia PCOS Epidemiology and Phenotype Study, conducted in Eastern Siberia (Russia) from 2016 to 2019. All participants (175 women of reproductive age: 26 women with PCOS (according to Rotterdam criteria (2003)) and hyperandrogenemia (increased levels of total testosterone (TT) and/or free androgenindex(FAI), and/ordehydroepiandrosterone sulphate (DHEAS)), 149 – without hyperandrogenemia) were recruited during the annual employment medical assessment. Methods included a questionnaire survey, anthropometry and modified Ferriman – Gallwey score, gynecological examination, pelvic ultrasound, and blood serum tests for TT, DHEAS, sex hormone-binding globulin, FAI, prolactin, thyroid-stimulating hormone, and 17-hydroxyprogesterone. Five indices of alpha diversity (amplicon sequencing variant, Shannon index, Simpson index, Chao index, and abundance-based coverage Index) were estimated for the gut microbiota using amplicon metasequencing. Statistical analysis included ROC-analysis for development of cut-off points for the indices, associated with hyperandrogenism in women of reproductive age with PCOS. Results. According to results of ROC-analysis, the greatest sensitivity with moderate specificity, with a high area under the curve was established for the Shannon and Simpson indices with cut-off points classifying women with or without hyperandrogenemia – 5.84 and 0.97, respectively.Conclusions. The developed criteria for assessing alpha diversity using cut-off points for the most significant indices can be useful for monitoring the results of different therapeutic interventions (prebiotics, probiotics, etc.) in hyperandrogenic phenotypes of PCOS.
Immune cells and tryptophan metabolism in the joint capsule tissue in rheumatoid arthritis
Authors: Stepanov E. A. 
Published: September 2024

To the present day, many links in the pathogenesis of rheumatoid arthritis remain unclear, which leads to unsatisfactory results in its therapy.The aim. To study the cells involved in immune reactions and tryptophan metabolites in the joint capsule in rheumatoid arthritis.Materials and methods. The experiments were carried out on 40 Wistar rats. Rheumatoid arthritis was induced by intraperitoneal injection of a solution of type 2 collagen (Chondrex Inc., USA) in incomplete Freund’s adjuvant. On the days 7, 14 and 21, the content of tryptophan, kynurenine, 3-hydrokenurinine, L-5-hydrotryptophan in the joint capsule was determined using high-performance liquid chromatography. Cells with CD3, CD20 and CD68 in joint tissues were studied at the same time using the streptavidin-biotin-peroxidase method. We used enzyme-linked immunosorbent method to determine antibodies to citrulline-containing peptide. Statistical analysis was performed using the Jamovi, version 2.3 software.Results. The content of cells carrying CD3, CD20 and CD68 markers in the joint was high in experimental rheumatoid arthritis. In joint tissues, the content of tryptophan metabolites along the kynurenine pathway also increases and the concentration of metabolites along the serotonin pathway decreases. Direct positive correlations of cells carrying CD3, CD20 and CD68 differential clusters with the content of tryptophan metabolites along the kynurenine pathway and negative correlations with metabolites of the serotonin pathway were established.Conclusions. Cells carrying CD3, CD20 and CD68 markers and tryptophan metabolites – kynurenine and L-5-hydrotryptophan – play an important role in the pathogenesis of rheumatoid arthritis.
Mannans: Obtaining from the cell walls of Saccharomyces cerevisiae yeast and assessing their adjuvant properties in a subunit vaccine model
Authors: Esina T. I. , Volosnikova E. A. , Shcherbakov D. N. , Volkova N. V. , Zaykovskaya A. V. , Shimina G. G. , Danilenko E. D. 
Published: September 2024

Background. Polysaccharides are known to possess adjuvant properties, they are biodegradable, safe, and are of low-labor production. In this regard, the development of polysaccharide-based adjuvants is an urgent task.The aim. To develop a method for obtaining mannans from the cell walls of Saccharomyces cerevisiae yeast and to study their adjuvant properties using subunit vaccine model.Materials and methods. The preparation of mannans was obtained from the Saccharomyces cerevisiae yeast by enzymatic and alkaline hydrolysis. Its adjuvant properties were assessed in BALB/c mice immunized with the recombinant receptor-binding domain (RBD) of the SARS-CoV-2 (S) protein (Delta (B.1.617.2)). The titers of specific antibodies in the blood sera were determined by ELISA assays using the recombinant RBD (Wuhan-Hu-1 and Delta), and the recombinant (S) protein (Wuhan-Hu-1, Delta and Omicron) as antigens. The titers of virus-neutralizing antibodies were determined using virus-neutralization tests with the SARS-CoV-2 virus strains Wuhan – hCoV19/Australia/VIC01/2020 (Wuhan-Hu-1), Delta – hCoV-19/Russia/PSK-2804/2021 (Delta (B.1.617.2)), and Omicron 1 – hCoV-19/Russia/Moscow171619-031221/2021 (Omicron (B.1.1.529)).Results. The developed scheme allowed for obtaining up to 200 mg of mannans from 10 g of yeast cell debris. Double, with a two-week interval, immunization with RBD (50 μg) in combination with mannans (40 μg and 10 μg) induced the production of specific antibodies in titers from 1:2477330 to 1:188360. The titer of virus-neutralizing antibodies to the Delta – hCoV-19/Russia/PSK-2804/2021 was 1:485 (40 μg of mannans per mouse).Conclusions. We developed a scheme for obtaining a low-toxic preparation of mannans from the Saccharomyces cerevisiae yeast. The highest adjuvant activity was achieved when using mannans at the dose of 40 µg per mouse. Blood sera obtained from the immunized animals neutralized both homologous and heterologous SARS-CoV-2 strains.
Peculiarities of the menstrual cycle in girls living in the Murmansk region
Authors: Grigorieva E. I. , Martynova A. A. 
Published: September 2024

The aim of the study. To assess the characteristics of the menstrual cycle and ovulation disorders in girls aged 15–17 years.Materials and methods. The study was carried out in 2022–2023 in the Murmansk region in Apatity. A total of 225 girls with average age of 16.5 ± 0.03 years took part in the study. The characteristics of the menstrual cycle and ovulation disorders were studied according to the guidelines of the International Federation of Gynecology and Obstetrics.Results of the study. In the study group, the onset of menarche (13.1 years) is observed at a later age compared to the girls living in other regions of Russia and neighboring countries (12.6–12.9 years). Every seventh girl has an irregular menstrual cycle, every fifth girl has a cycle duration of more than 38 days. Heavy menstruation occurs in every third girl, intermenstrual uterine bleeding – in every thirteenth girl. Half of the girls have painful periods (dysmenorrhea). Among ovulation disorders, the most common is abnormal uterine bleeding – 34.7 %. Also, intermenstrual uterine bleeding (8.0 %), primary amenorrhea (2.7 %) and polycystic ovary syndrome (1.3 %) are registered. Among gynecological pathology, in addition to ovulation disorders, we registered vulvovaginal candidiasis and paraurethral cyst.Conclusion. The analysis of the obtained results showed that only 20.4 % of girls do not have gynecological pathology, which to a certain extent indicates a low level of reproductive health of girls. Asaresult, it is necessary to diagnose and treat diseases which can cause the development of ovulation disorders more carefully and at earlier stages of sexual development. The work was carried out as part of the research topic No. FMEZ-2022-0012.