bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ortholog Receptor Or67d in Drosophila Bipectinata is able to Detect Two Different Pheromones
Authors: Díaz-Morales Melissa , Khallaf Mohammed A. , Stieber Regina , Alali Ibrahim , Hansson Bill S. , Knaden Markus 
Published: September 2024

AbstractSex pheromones play a crucial role in species recognition and reproductive isolation. Despite being largely species-specific in drosophilids, the mechanisms underlying pheromone detection, production, and their influence on mating behavior remain poorly understood. Here, we compare the chemical profiles of Drosophila bipectinata and D. melanogaster, the mating behaviors in both species, as well as the tuning properties of Or67d receptors, which are expressed by neurons in antennal trichoid sensilla at1. Through single sensillum recordings, we demonstrate that the D. bipectinata Or67d-ortholog exhibits similar sensitivity to cis-vaccenyl acetate (cVA) as compared to D. melanogaster but in addition also responds uniquely to (Z)-11-eicosen-1-yl-acetate (Z11-20:Ac), a compound exclusively produced by D. bipectinata males. Through courtship behavior assays we found that, surprisingly, perfuming the flies with Z11-20:Ac did not reveal any aphrodisiacal or anti-aphrodisiacal effects in mating assays. The behavioral relevance of at1 neuron channels in D. bipectinata compared to D. melanogaster seems to be restricted to its formerly shown function as an aggregation pheromone. Moreover, the non-specific compound cVA affected copulation negatively in D. bipectinata and could potentially act as a premating isolation barrier. As both ligands of Or67d seem to govern different behaviors in D. bipectinata, additional neurons detecting at least one of those compounds might be involved. These results underscore the complexity of chemical signaling in species recognition and raise intriguing questions about the evolutionary implications of pheromone detection pathways in Drosophila species.
The status of History in the subject-selection ‘marketplace’: Insights from Australian students
Authors: Cairns Rebecca , Garrard Kerri Anne 
Published: September 2024

Abstract
Concern about declining enrollments in senior school History subjects has been a regular feature of history education discourse in Australia for at least 30 years. This concern is also evident in international discourse about History being a subject “in crisis”. In Australia and elsewhere, there has been increased speculation about the reasons History enrollments are contracting. However, students are not often included in these discussions, and the external conditions affecting their subject choices tend to be overlooked. Our mixed methods research draws on descriptive statistics and thematic analysis of data from an online survey of 293 students in years 10, 11, and 12 from across Australia. This article examines influences on History’s status in the subject ‘marketplace’ from the perspective of students and conceptualizes three sets of influences: instrumental, subject status, and local context. We position this work in the context of history education, subject selection, careers education research literature, and policy. The dominance of instrumental influences on the decisions of participants to choose or reject History as a senior secondary subject also leads us to examine how, in uncertain times, the forces of neoliberalism are shaping young people’s perceptions of the alignment of school and future work.
Automatic gender detection: a methodological procedure and recommendations to computationally infer the gender from names with ChatGPT and gender APIs
Authors: Goyanes Manuel , de-Marcos Luis , Domínguez-Díaz Adrián 
Published: September 2024

AbstractBoth computational social scientists and scientometric scholars alike, interested in gender-related research questions, need to classify the gender of observations. However, in most public and private databases, this information is typically unavailable, making it difficult to design studies aimed at understanding the role of gender in influencing citizens’ perceptions, attitudes, and behaviors. Against this backdrop, it is essential to design methodological procedures to infer the gender automatically and computationally from data already provided, thus facilitating the exploration and examination of gender-related research questions or hypotheses. Researchers can use automatic gender detection tools like Namsor or Gender-API, which are already on the market. However, recent developments in conversational bots offer a new, still relatively underexplored, alternative. This study offers a step-by-step research guide, with relevant examples and detailed clarifications, to automatically classify the gender from names through ChatGPT and two partially free gender detection tool (Namsor and Gender-API). In addition, the study provides methodological suggestions and recommendations on how to gather, interpret, and report results coming from both platforms. The study methodologically contributes to the scientometric literature by describing an easy-to-execute methodological procedure that enables the computational codification of gender from names. This procedure could be implemented by scholars without advanced computing skills.
Building capacity in institutional research: collaboration and complementarity?
Authors: Botha Jan , Webber Karen , Williams James , Woodfield Steve 
Published: September 2024

AbstractInstitutional Research associations across the world are re-imagining and redesigning their professional development and capacity building activities. This paper outlines the professional development activities of the Association for Institutional Research (AIR) in the United States (est. 1966), the European Association for Institutional Research (EAIR) (est. 1978), the Southern African Association for Institutional Research (SAAIR) (est. 1994) and the United Kingdom and Ireland Higher Education Institutional Research Network (HEIR) (est. 2008) and argues that a more sophisticated approach to IR is needed, informed by systems thinking, aimed at proactive engagement with policy-makers and managers, organisational learning, direct links to institutional strategy (‘a seat at the table’), and the analysis and use of larger volumes of data.
Evaluation of ballistics euthanasia applied to stranded cetaceans using ethological and post-mortem computed tomography assessment
Authors: Boys Rebecca M. , Kot Brian C. W. , Lye Gordon , Beausoleil Ngaio J. , Hunter Stuart , Stockin Karen A. 
Published: September 2024

AbstractDebilitated stranded cetaceans with low survival likelihood, may require euthanasia to avoid further suffering. Euthanasia can involve chemical or physical methods, including ballistics. Ballistics should cause instantaneous, permanent insensibility through brainstem disruption. Despite wide application, there is limited understanding of ballistics-related welfare outcomes. We opportunistically examined behaviour of three maternally-dependent cetaceans following shooting and the related cranial disruption post-mortem using computed tomography (PMCT). Our aim was to understand whether a ‘humane death’, i.e., euthanasia, was achieved. Each animal was shot using different projectile types: soft non-bonded, solid, and soft bonded. In two animals, insensibility was not immediately assessed following shooting, although both were reported as ‘instantaneously insensible’. From our analysis, all animals displayed musculoskeletal responses to shooting, including peduncle stiffening and slack lower jaw, followed by musculature relaxation 24-, 10.3- and 20.8-seconds post-ballistics, respectively. The animal shot with a soft non-bonded projectile also displayed agonal convulsions and tail-lifting for 16-seconds post-shot; these were not observed for solid or soft bonded projectiles. PMCT findings indicated projectile disruption to the brainstem and/or spinal cord likely to cause near-instantaneous insensibility. However, extra-cranial wounding was also evident for the soft non-bonded projectile, highlighting potential for additional welfare compromise. Our results demonstrate that ballistics can achieve a relatively rapid death in young, stranded cetaceans, but careful equipment selection is required. To ensure a humane death, verification of insensibility must be undertaken immediately following shooting. Further studies should be undertaken to improve knowledge of appropriate procedures and equipment for euthanasia, ensuring humane deaths for compromised cetaceans.
In Search of Lost Online Test-Time Adaptation: A Survey
Authors: Wang Zixin , Luo Yadan , Zheng Liang , Chen Zhuoxiao , Wang Sen , Huang Zi 
Published: September 2024

Abstract
This article presents a comprehensive survey of online test-time adaptation (OTTA), focusing on effectively adapting machine learning models to distributionally different target data upon batch arrival. Despite the recent proliferation of OTTA methods, conclusions from previous studies are inconsistent due to ambiguous settings, outdated backbones, and inconsistent hyperparameter tuning, which obscure core challenges and hinder reproducibility. To enhance clarity and enable rigorous comparison, we classify OTTA techniques into three primary categories and benchmark them using a modern backbone, the Vision Transformer. Our benchmarks cover conventional corrupted datasets such as CIFAR-10/100-C and ImageNet-C, as well as real-world shifts represented by CIFAR-10.1, OfficeHome, and CIFAR-10-Warehouse. The CIFAR-10-Warehouse dataset includes a variety of variations from different search engines and synthesized data generated through diffusion models. To measure efficiency in online scenarios, we introduce novel evaluation metrics, including GFLOPs, wall clock time, and GPU memory usage, providing a clearer picture of the trade-offs between adaptation accuracy and computational overhead. Our findings diverge from existing literature, revealing that (1) transformers demonstrate heightened resilience to diverse domain shifts, (2) the efficacy of many OTTA methods relies on large batch sizes, and (3) stability in optimization and resistance to perturbations are crucial during adaptation, particularly when the batch size is 1. Based on these insights, we highlight promising directions for future research. Our benchmarking toolkit and source code are available at https://github.com/Jo-wang/OTTA_ViT_survey.
Suspended Load Estimation in Data Scarce Rivers
Authors: Efthimiou Nikolaos 
Published: September 2024

Abstract
Sediment rating curves (SRCs) are tools of satisfactory reliability in the attempt to describe the sediment regime in catchments with limited or poor-quality records. The study valorised the most suitable SRC development method for the estimation of the coarse suspended sediment load at the outlet of nine Mediterranean sub-watersheds. Four established grouping techniques were assessed, to minimize the uncertainty of the results, namely simple rating curve, different ratings for the dry and wet season of the year, hydrographic classification, and broken line interpolation, at three major Greek rivers (Aliakmon, Acheloos – upper route, Arachthos). The methods’ performance was benchmarked against sediment discharge field records, utilizing statistical measures and graphical analyses. The necessary observations were conducted by the Greek Public Power Corporation. The results were site/station dependent, and no methodology emerged as universally accepted. The analysis designated that the simple rating curve performs best at the cross-sections Moni Ilarion, Moni Prodromou, and Arta bridge, the different ratings for the dry and wet season of the year at Grevena bridge and Gogo bridge, the hydrographic classification at Velventos and Plaka bridge, and the broken line interpolation at Avlaki dam and Tsimovo bridge. In this regard, the study advocates the use of multiple SRC methods. Despite its limitations, the method merits a rather simple and cost-effective generation of a (continuous, detailed, sufficiently accurate) synthetic suspended sediment discharge timeseries, with high interpolating, extrapolating and reproducibility potential. The success of the application could benefit, among others, water quality restoration and dam management operations.
Usefulness of the Primary Tumor Standardized Uptake Value of Iodine-123 Metaiodobenzylguanidine for Predicting Metastatic Potential in Pheochromocytoma and Paraganglioma
Authors: Hirahara Mitsuho , Nakajo Masatoyo , Kitazano Ikumi , Jinguji Megumi , Tani Atsushi , Takumi Koji , Kamimura Kiyohisa , Tanimoto Akihide , Yoshiura Takashi 
Published: September 2024

Abstract
Purpose
To examine the usefulness of semi-quantitative analysis using the standardized uptake value (SUV) of iodine-123 metaiodobenzylguanidine ([123I]-MIBG) for predicting metastatic potential in patients with pheochromocytoma (PHEO) and paraganglioma (PGL).

Procedures
This study included 18 PHEO and 2 PGL patients. [123I]-MIBG visibility and SUV-related parameters (SUVmax, SUVmean, tumor volume of [123I]-MIBG uptake [TV_MIBG], and total lesion [123I]-MIBG uptake) were compared with the pathological grading obtained using the Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and the Grading System for Adrenal Pheochromocytoma and Paraganglioma (GAPP), which are used to predict metastatic potential. The PASS scores were categorized as < 4 and ≥ 4. Based on the GAPP scores, PHEOs/PGLs were categorized as follows: well, moderately, and poorly differentiated tumors. The Mann–Whitney U test or Spearman’s rank correlation was used to assess differences or associations between two quantitative variables.

Results
All PHEOs/PGLs were visualized on [123I]-MIBG scintigraphy. There were 16 PASS < 4 and 4 PASS ≥ 4 tumors. Moreover, 11 and 9 tumors were well and moderately differentiated, respectively. The uptake scores and SUV-related parameters significantly differed between tumors with a PASS score of < 4 and those with a PASS score of ≥ 4 (each, p > 0.05). Moderately differentiated tumors had significantly higher uptake scores and SUV-related parameters except TV_MIBG than well-differentiated tumors (each, p < 0.05). The GAPP score was positively correlated with the uptake scores and SUV-related parameters (each, p < 0.05) except TV_MIBG.

Conclusions
The primary tumor [123I]-MIBG uptake assessed using SUV-related parameters can be an imaging tool for predicting metastatic potential in patients with PHEO/PGL.
Vertraute Lebenswelten der Wissenschaftsskepsis. Die Kritik an der Corona-Impfpflicht als Präludium für den Widerstand gegen interventionistische Nachhaltigkeitspolitik
Authors: Pfadenhauer Michaela , Miko-Schefzig Katharina , Buckenleib Arthur , Reiter Cornelia 
Published: September 2024

ZusammenfassungDie Ankündigung einer Impfpflicht im November 2021 in Österreich steht in einer langen Reihe politischer Verordnungen zur Eindämmung der COVID-19-Pandemie. Diese als Eingriffe eines interventionistischen Staates in private Belange wahrgenommenen Maßnahmen hatten umfassende Proteste und Kritik zur Folge. Deren Deutung als verschwörungstheoretische Haltung am gesellschaftlichen Rand ist nicht mit der Bandbreite von Institutionen- und Wissenschaftsskepsis kompatibel, die in der Ablehnung der COVID-19-Impfung zum Ausdruck kommt. Der vorliegende Beitrag präsentiert die Befunde ethnographischer Interviews mit maßnahmenkritischen Personen in der Mitte der Gesellschaft. Die Kombination von Lebensweltanalyse und Subjektivierungsanalyse fördert diskursbezogene Selbstpositionierungen und deren Relevanzsetzungen sowie die Verschiebung sozialer Bezugnahmen während der Pandemie zutage. Die empirisch gewonnene Selbstpositionierung als „wissende Minderheit ohne Resonanzraum“ offenbart die Erfahrung eines Wir, das sich als Bezugsgruppe im Sinne von „small lifeworlds“ darstellt. Ihre Rekonstruktion legt ein transformatorisches Potenzial frei, das nicht zuletzt im Hinblick auf die zu gewärtigende Interventionspolitik zur Bewältigung der Klimakrise gesellschaftlich relevant sein dürfte.
Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain
Authors: Li Hao , Li Ying , Wang Ting , Li Shen , Liu Heli , Ning Shuyi , Shen Wei , Zhao Zhe , Wu Haitao 
Published: September 2024

Abstract
The oxytocin receptor (OXTR) has garnered increasing attention for its role in regulating both mature behaviors and brain development. It has been established that OXTR mediates a range of effects that are region-specific or period-specific. However, the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution. Therefore, our objective was to generate a comprehensive, high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain. We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages (P7, P14, P21, P28, P42, P56). We provide detailed descriptions of Oxtr expression patterns in key brain regions, including the cortex, basal forebrain, hippocampus, and amygdaloid complex, with a focus on the precise localization of Oxtr
+ cells and the variance of expression between different neurons. Furthermore, we identified some neuronal populations with high Oxtr expression levels that have been little studied, including glutamatergic neurons in the ventral dentate gyrus, Vgat
+
Oxtr
+ cells in the basal forebrain, and GABAergic neurons in layers 4/5 of the cortex. Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.
Effects of the English language intervention as a foreign language for struggling elementary readers in South Korea: a meta-analysis
Authors: Shin HyeYun Gladys , Kim Dongil 
Published: September 2024

AbstractThis meta-analysis comprehensively examined the effects of English language interventions on struggling elementary school learners in South Korea learning English as a foreign language. A total of 22 studies of experimental and quasi-experimental studies were separately analyzed by the study design using a random-effects model, and the mean effect size was medium (g = 0.68, SE = 0.26, CI95 = 0.18, 1.18, p < 0.01) for the experimental studies while the mean effect size was large (g = 1.39, SE = 0.67, CI95 = 0.08, 2.69, p < 0.05) for the quasi-experimental studies. Due to the large homogeneity statistics, subgroup analyses were additionally conducted for possible moderator effects contributing to the mean. The subgroup analyses indicated large effects in the affective (e.g., student’s motivation) and achievement (e.g., reading comprehension) type of outcome measures and effective intervention components (e.g., shared reading). Other effective contextual characteristics including the total session numbers, intervention frequency, and classroom type are also discussed along with the study limitations and future directions for the struggling readers learning English as a foreign language.
Prognostic determinants in cancer survival: a multidimensional evaluation of clinical and genetic factors across 10 cancer types in the participants of Genomics England’s 100,000 Genomes Project
Authors: Gammall Jurgita , Lai Alvina G. 
Published: September 2024

Abstract
Background
Cancer is a complex disease, caused and impacted by a combination of genetic, demographic, clinical, environmental and lifestyle factors. Analysis of cancer characteristics, risk factors, treatment options and the heterogeneity across cancer types has been the focus of medical research for years. The aim of this study is to describe and summarise genetic, clinicopathological, behavioural and demographic characteristics and their differences across ten common cancer types and evaluate their impact on overall survival outcomes.

Methods
This study included data from 9977 patients with bladder, breast, colorectal, endometrial, glioma, leukaemia, lung, ovarian, prostate, and renal cancers. Genetic data collected through the 100,000 Genomes Project was linked with clinical and demographic data provided by the National Cancer Registration and Analysis Service (NCRAS), Hospital Episode Statistics (HES) and Office for National Statistics (ONS). Descriptive and Kaplan Meier survival analyses were performed to visualise similarities and differences across cancer types. Cox proportional hazards regression models were applied to identify statistically significant prognostic factor associations with overall survival.

Results
161 clinical and 124 genetic factors were evaluated for prognostic association with overall survival. Of these, 116 unique factors were found to have significant prognostic effect for overall survival across ten cancer types when adjusted for age, sex and stage. The findings confirmed prognostic associations with overall survival identified in previous studies in factors such as multimorbidity, tumour mutational burden, and mutations in genes BRAF, CDH1, NF1, NRAS, PIK3CA, PTEN, TP53. The results also identified new prognostic associations with overall survival in factors such as mental health conditions, female health-related conditions, previous hospital encounters and mutations in genes FANCE, FBXW7, GATA3, MSH6, PTPN11, RB1, RNF43.

Conclusion
This study provides a comprehensive view of clinicopathological and genetic prognostic factors across different cancer types and draws attention to less commonly known factors which might help produce more precise prognosis and survival estimates. The results from this study contribute to the understanding of cancer disease and could be used by researchers to develop complex prognostic models, which in turn could help predict cancer prognosis more accurately and improve patient outcomes.
Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE)
Authors: Fortington Lauren V. , Cassidy J. David , Castellani Rudolph J. , Gardner Andrew J. , McIntosh Andrew S. , Austen Michael , Kerr Zachary Yukio , Quarrie Kenneth L. 
Published: September 2024

AbstractDetermining whether repetitive head impacts (RHI) cause the development of chronic traumatic encephalopathy (CTE)-neuropathological change (NC) and whether pathological changes cause clinical syndromes are topics of considerable interest to the global sports medicine community. In 2022, an article was published that used the Bradford Hill criteria to evaluate the claim that RHI cause CTE. The publication garnered international media attention and has since been promoted as definitive proof that causality has been established. Our counterpoint presents an appraisal of the published article in terms of the claims made and the scientific literature used in developing those claims. We conclude that the evidence provided does not justify the causal claims. We discuss how causes are conceptualised in modern epidemiology and highlight shortcomings in the current definitions and measurement of exposures (RHI) and outcomes (CTE). We address the Bradford Hill arguments that are used as evidence in the original review and conclude that assertions of causality having been established are premature. Members of the scientific community must be cautious of making causal claims until the proposed exposures and outcomes are well defined and consistently measured, and findings from appropriately designed studies have been published. Evaluating and reflecting on the quality of research is a crucial step in providing accurate evidence-based information to the public.
Graphical abstract