bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periprosthetic Infection following Primary Hip and Knee Arthroplasty: The Impact of Limiting the Postoperative Surveillance Period
Authors: Roth Virginia R. , Mitchell Robyn , Vachon Julie , Alexandre Stéphanie , Amaratunga Kanchana , Smith Stephanie , Vearncombe Mary , Davis Ian , Mertz Dominik , Henderson Elizabeth , John Michael , Johnston Lynn , Lemieux Camille , Pelude Linda , Gravel Denise ,   the Canadian Nosocomial Infection Surveillance Program
Published: November 2016

BACKGROUNDHip and knee arthroplasty infections are associated with considerable healthcare costs. The merits of reducing the postoperative surveillance period from 1 year to 90 days have been debated.OBJECTIVESTo report the first pan-Canadian hip and knee periprosthetic joint infection (PJI) rates and to describe the implications of a shorter (90-day) postoperative surveillance period.METHODSProspective surveillance for infection following hip and knee arthroplasty was conducted by hospitals participating in the Canadian Nosocomial Infection Surveillance Program (CNISP) using standard surveillance definitions.RESULTSOverall hip and knee PJI rates were 1.64 and 1.52 per 100 procedures, respectively. Deep incisional and organ-space hip and knee PJI rates were 0.96 and 0.71, respectively. In total, 93% of hip PJIs and 92% of knee PJIs were identified within 90 days, with a median time to detection of 21 days. However, 11%–16% of deep incisional and organ-space infections were not detected within 90 days. This rate was reduced to 3%–4% at 180 days post procedure. Anaerobic and polymicrobial infections had the shortest median time from procedure to detection (17 and 18 days, respectively) compared with infections due to other microorganisms, including Staphylococcus aureus.CONCLUSIONSPJI rates were similar to those reported elsewhere, although differences in national surveillance systems limit direct comparisons. Our results suggest that a postoperative surveillance period of 90 days will detect the majority of PJIs; however, up to 16% of deep incisional and organ-space infections may be missed. Extending the surveillance period to 180 days could allow for a better estimate of disease burden.Infect Control Hosp Epidemiol 2017;38:147–153
Maternal depressive symptoms and early childhood cognitive development: a meta-analysis
Authors: Liu Y. , Kaaya S. , Chai J. , McCoy D. C. , Surkan P. J. , Black M. M. , Sutter-Dallay A.-L. , Verdoux H. , Smith-Fawzi M. C. 
Published: November 2016

BackgroundPrevious findings have been mixed regarding the relationship between maternal depressive symptoms and child cognitive development. The objective of this study was to systematically review relevant literature and to perform a meta-analysis.MethodThree electronic databases (PubMed, EMBASE, PsycINFO) were searched. Initial screening was conducted independently by two reviewers. Studies selected for detailed review were read in full and included based on a set of criteria. Data from selected studies were abstracted onto a standardized form. Meta-analysis using the inverse variance approach and random-effects models was conducted.ResultsThe univariate analysis of 14 studies revealed that maternal depressive symptoms are related to lower cognitive scores among children aged ⩽56 months (Cohen's d = −0.25, 95% CI −0.39 to −0.12). The synthesis of studies controlling for confounding variables showed that the mean cognitive score for children 6–8 weeks post-partum whose mothers had high depressive symptoms during the first few weeks postpartum was approximately 4.2 units lower on the Mental Developmental Index (MDI) of the Bayley Scales of Infant and Toddler Development (BSID) compared with children with non-symptomatic mothers (B̂ = −4.17, 95% CI −8.01 to −0.32).ConclusionsThe results indicated that maternal depressive symptoms are related to lower cognitive scores in early infancy, after adjusting for confounding factors. An integrated approach for supporting child cognitive development may include program efforts that promote maternal mental health in addition to family economic wellbeing, responsive caregiving, and child nutrition.
George Orwell on politics and war
Authors: Stone John 
Published: November 2016

AbstractGeorge Orwell is not generally remembered for his views on strategy. Nevertheless a careful reading of his written work reveals a coherent appreciation of war’s strategic dimension. For Orwell, war is a necessary adjunct to politics, and the utility of strategic action should be based on rational considerations of cost and benefit. He rejected pacifism and self-imposed restraints on warfare on the basis that such positions proceeded from unexamined emotional commitments, and were neither instrumentally nor morally sound. He also maintained that the enemy’s political values are an essential input into effective strategic calculations. On this latter basis he criticised the strategic prescriptions of H. G. Wells and B. H. Liddell Hart for limited war with Nazi Germany.
Persistent fever with chills and an endocardial mass in a child: an unusual presentation of Hughes–Stovin syndrome
Authors: Fabi Marianna , Lami Francesca , Zompatori Maurizio 
Published: November 2016

AbstractA 12-year-old boy with a right atrium endocardial mass was initially diagnosed as having Lemierre’s syndrome on the basis of previous mastoiditis and jugular vein and cerebral venous thrombosis. Lack of response to antibiotics, persistent high fever with chills, acute-phase reactants, and peripheral arterial pseudoaneurysms made us reconsider the diagnosis. Only after the late appearance of radiological pulmonary lesions and recognition of pulmonary artery aneurysms, Hughes–Stovin syndrome was diagnosed. Hughes–Stovin syndrome is an exceedingly rare vasculitis, especially in childhood, consisting of multiple pulmonary artery aneurysms and deep venous thromboses. The lack of formal diagnostic criteria and the rarity of the disease make the diagnosis very challenging, especially when respiratory complaints are not present at onset, as in the presented case. The treatment aims to reduce inflammation, although there is debate about anticoagulation therapy because of the risk of pulmonary haemorrhage.
Does Top-Down Feedback Modulate the Encoding of Orthographic	Representations During Visual-Word Recognition?
Authors: Perea Manuel , Marcet Ana , Vergara-Martínez Marta 
Published: November 2016

Abstract. In masked priming lexical decision experiments, there is a matched-case identity advantage for nonwords, but not for words (e.g., ERTAR-ERTAR < ertar-ERTAR; ALTAR-ALTAR = altar-ALTAR). This dissociation has been interpreted in terms of feedback from higher levels of processing during orthographic encoding. Here, we examined whether a matched-case identity advantage also occurs for words when top-down feedback is minimized. We employed a task that taps prelexical orthographic processes: the masked prime same-different task. For “same” trials, results showed faster response times for targets when preceded by a briefly presented matched-case identity prime than when preceded by a mismatched-case identity prime. Importantly, this advantage was similar in magnitude for nonwords and words. This finding constrains the interplay of bottom-up versus top-down mechanisms in models of visual-word identification.
Improved survival for patients diagnosed with chronic lymphocytic leukemia in the era of chemo-immunotherapy: a Danish population-based study of 10455 patients
Authors: da Cunha-Bang C , Simonsen J , Rostgaard K , Geisler C , Hjalgrim H , Niemann C U 
Published: November 2016

AbstractThe treatment of chronic lymphocytic leukemia (CLL) is in rapid transition, and during recent decades both combination chemotherapy and immunotherapy have been introduced. To evaluate the effects of this development, we identified all CLL patients registered in the nation-wide Danish Cancer Register between 1978 and 2013. We identified 10 455 CLL patients and 508 995 CLL-free control persons from the general population. Compared with the latter, the relative mortality rate between CLL patients and their controls decreased from 3.4 (95% CI 3.2–3.6) to 1.9 (95% CI 1.7–2.1) for patients diagnosed in 1978–1984 and 2006–2013, respectively. The improved survival corresponded to a decreasing risk of death from malignant hematological diseases, whereas the risk of death from infections was stable during the study period. These population-based data substantiate the improved survival for patients treated with chemo-immunotherapy demonstrated in clinical studies.
More frequent intense and long-lived storms dominate the springtime trend in central US rainfall
Authors: Feng Zhe , Leung L. Ruby , Hagos Samson , Houze Robert A. , Burleyson Casey D. , Balaguru Karthik 
Published: November 2016

AbstractThe changes in extreme rainfall associated with a warming climate have drawn significant attention in recent years. Mounting evidence shows that sub-daily convective rainfall extremes are increasing faster than the rate of change in the atmospheric precipitable water capacity with a warming climate. However, the response of extreme precipitation depends on the type of storm supported by the meteorological environment. Here using long-term satellite, surface radar and rain-gauge network data and atmospheric reanalyses, we show that the observed increases in springtime total and extreme rainfall in the central United States are dominated by mesoscale convective systems (MCSs), the largest type of convective storm, with increased frequency and intensity of long-lasting MCSs. A strengthening of the southerly low-level jet and its associated moisture transport in the Central/Northern Great Plains, in the overall climatology and particularly on days with long-lasting MCSs, accounts for the changes in the precipitation produced by these storms.
Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators
Authors: Malvar O. , Ruz J. J. , Kosaka P. M. , Domínguez C. M. , Gil-Santos E. , Calleja M. , Tamayo J. 
Published: November 2016

AbstractThe identification of species is a fundamental problem in analytical chemistry and biology. Mass spectrometers identify species by their molecular mass with extremely high sensitivity (<10−24 g). However, its application is usually limited to light analytes (<10−19 g). Here we demonstrate that by using nanomechanical resonators, heavier analytes can be identified by their mass and stiffness. The method is demonstrated with spherical gold nanoparticles and whole intact E. coli bacteria delivered by electrospray ionization to microcantilever resonators placed in low vacuum at 0.1 torr. We develop a theoretical procedure for obtaining the mass, position and stiffness of the analytes arriving the resonator from the adsorption-induced eigenfrequency jumps. These results demonstrate the enormous potential of this technology for identification of large biological complexes near their native conformation, a goal that is beyond the capabilities of conventional mass spectrometers.
Mitigating Herding in Hierarchical Crowdsourcing Networks
Authors: Yu Han , Miao Chunyan , Leung Cyril , Chen Yiqiang , Fauvel Simon , Lesser Victor R. , Yang Qiang 
Published: November 2016

AbstractHierarchical crowdsourcing networks (HCNs) provide a useful mechanism for social mobilization. However, spontaneous evolution of the complex resource allocation dynamics can lead to undesirable herding behaviours in which a small group of reputable workers are overloaded while leaving other workers idle. Existing herding control mechanisms designed for typical crowdsourcing systems are not effective in HCNs. In order to bridge this gap, we investigate the herding dynamics in HCNs and propose a Lyapunov optimization based decision support approach - the Reputation-aware Task Sub-delegation approach with dynamic worker effort Pricing (RTS-P) - with objective functions aiming to achieve superlinear time-averaged collective productivity in an HCN. By considering the workers’ current reputation, workload, eagerness to work, and trust relationships, RTS-P provides a systematic approach to mitigate herding by helping workers make joint decisions on task sub-delegation, task acceptance, and effort pricing in a distributed manner. It is an individual-level decision support approach which results in the emergence of productive and robust collective patterns in HCNs. High resolution simulations demonstrate that RTS-P mitigates herding more effectively than state-of-the-art approaches.
Mixing of quantum states: A new route to creating optical activity
Authors: Baimuratov Anvar S. , Tepliakov Nikita V. , Gun’ko Yurii K. , Baranov Alexander V. , Fedorov Anatoly V. , Rukhlenko Ivan D. 
Published: November 2016

AbstractThe ability to induce optical activity in nanoparticles and dynamically control its strength is of great practical importance due to potential applications in various areas, including biochemistry, toxicology, and pharmaceutical science. Here we propose a new method of creating optical activity in originally achiral quantum nanostructures based on the mixing of their energy states of different parities. The mixing can be achieved by selective excitation of specific states or via perturbing all the states in a controllable fashion. We analyze the general features of the so produced optical activity and elucidate the conditions required to realize the total dissymmetry of optical response. The proposed approach is applicable to a broad variety of real systems that can be used to advance chiroptical devices and methods.
Tracking modern human population history from linguistic and cranial phenotype
Authors: Reyes-Centeno Hugo , Harvati Katerina , Jäger Gerhard 
Published: November 2016

AbstractLanguages and genes arguably follow parallel evolutionary trajectories, descending from a common source and subsequently differentiating. However, although common ancestry is established within language families, it remains controversial whether language preserves a deep historical signal. To address this question, we evaluate the association between linguistic and geographic distances across 265 language families, as well as between linguistic, geographic, and cranial distances among eleven populations from Africa, Asia, and Australia. We take advantage of differential population history signals reflected by human cranial anatomy, where temporal bone shape reliably tracks deep population history and neutral genetic changes, while facial shape is more strongly associated with recent environmental effects. We show that linguistic distances are strongly geographically patterned, even within widely dispersed groups. However, they are correlated predominantly with facial, rather than temporal bone, morphology, suggesting that variation in vocabulary likely tracks relatively recent events and possibly population contact.
Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling
Authors: Bedada Fikru B. , Martindale Joshua J. , Arden Erik , Metzger Joseph M. 
Published: November 2016

AbstractMolecular inotropy refers to cardiac contractility that can be modified to affect overall heart pump performance. Here we show evidence of a new molecular pathway for positive inotropy by a cardiac-restricted microRNA (miR). We report enhanced cardiac myocyte performance by acute titration of cardiac myosin-embedded miR-208a. The observed positive effect was independent of host gene myosin effects with evidence of negative regulation of cAMP-specific 3′,5′-cyclic phosphodiesterase 4D (PDE4D) and the regulatory subunit of PKA (PRKAR1α) content culminating in PKA-site dependent phosphorylation of cardiac troponin I (cTnI) and phospholamban (PLN). Further, acute inhibition of miR-208a in adult myocytes in vitro increased PDE4D expression causing reduced isoproterenol-mediated phosphorylation of cTnI and PLN. Next, rAAV-mediated miR-208a gene delivery enhanced heart contractility and relaxation parameters in vivo. Finally, acute inducible increases in cardiac miR-208a in vivo reduced PDE4D and PRKAR1α, with evidence of increased content of several complementary miRs harboring the PDE4D recognition sequence. Physiologically, this resulted in significant cardiac cTnI and PLN phosphorylation and improved heart performance in vivo. As phosphorylation of cTnI and PLN is critical to myocyte function, titration of miR-208a represents a potential new mechanism to enhance myocardial performance via the PDE4D/PRKAR1α/PKA phosphoprotein signaling pathway.
The cytotoxic synergy of nanosecond electric pulses and low temperature leads to apoptosis
Authors: Muratori Claudia , Pakhomov Andrei G. , Gianulis Elena C. , Jensen Sarah Damsbo , Pakhomova Olga N. 
Published: November 2016

AbstractElectroporation by nanosecond electric pulses (nsEP) is an emerging modality for tumor ablation. Here we show the efficient induction of apoptosis even by a non-toxic nsEP exposure when it is followed by a 30-min chilling on ice. This chilling itself had no impact on the survival of U-937 or HPAF-II cells, but caused more than 75% lethality in nsEP-treated cells (300 ns, 1.8-7 kV/cm, 50-700 pulses). The cell death was largely delayed by 5-23 hr and was accompanied by a 5-fold activation of caspase 3/7 (compared to nsEP without chilling) and more than 60% cleavage of poly-ADP ribose polymerase (compared to less than 5% in controls or after nsEP or chilling applied separately). When nsEP caused a transient permeabilization of 83% of cells to propidium iodide, cells placed at 37 °C resealed in 10 min, whereas 60% of cells placed on ice remained propidium-permeable even in 30 min. The delayed membrane resealing caused cell swelling, which could be blocked by an isosmotic addition of a pore-impermeable solute (sucrose). However, the block of swelling did not prevent the delayed cell death by apoptosis. The potent enhancement of nsEP cytotoxicity by subsequent non-damaging chilling may find applications in tumor ablation therapies.
A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group
Authors: Shen Chunmei , Zhu Bofeng , Yao Tianhua , Li Zhidan , Zhang Yudang , Yan Jiangwei , Wang Bo , Bie Xiaohua , Tai Fadao 
Published: November 2016

AbstractIn the present study, thirty autosomal insertion and deletion polymorphic loci were simultaneously amplified and genotyped in a multiplex system, and their allelic frequencies as well as several forensic parameters were obtained in a sample of 236 unrelated healthy Tujia individuals. All the loci were in Hardy-Weinberg equilibrium after applying a Bonferroni correction and all pair-wise loci showed no significant linkage disequilibrium. These loci were observed to be relatively informative and discriminating, quite efficient for forensic applications. Allelic frequencies of 30 loci were compared between the Tujia group and other reference populations, and the results of analysis of molecular variance indicated the Tujia group showed the least significant differences with the Shanghai Han at one locus, and the most with Central Spanish population at 22 loci. We analyzed the population genetic structure by the principal component analysis, the clustering of STRUCTURE program and a Neighbor-Joining tree, and then evaluated the genetic relationships among Tujia and other 15 populations.
Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue
Authors: Hou Yuelan , Sheng Zhen , Mao Xiaobing , Li Chenzheng , Chen Jingying , Zhang Jingjing , Huang Honghui , Ruan Hua , Luo Lingfei , Li Li 
Published: November 2016

AbstractEmergency granulopoiesis occurs in response to severe microbial infection. However, whether and how other blood components, particularly monocytes/macrophages and their progenitors, including hematopoietic stem/progenitor cells (HSPCs), participate in the process and the underlying molecular mechanisms remain unknown. In this study, we challenged zebrafish larvae via direct injection of Escherichia coli into the bloodstream, which resulted in systemic inoculation with this microbe. The reaction of hematopoietic cells, including HSPCs, in the caudal hematopoietic tissue was carefully analysed. Both macrophages and neutrophils clearly expanded following the challenge. Thus, emergency myelopoiesis, including monopoiesis and granulopoiesis, occurred following systemic bacterial infection. The HSPC reaction was dependent on the bacterial burden, manifesting as a slight increase under low burden, but an obvious reduction following the administration of an excessive volume of bacteria. Pu.1 was important for the effective elimination of the microbes to prevent excessive HSPC apoptosis in response to stress. Moreover, Pu.1 played different roles in steady and emergency monopoiesis. Although Pu.1 was essential for normal macrophage development, it played suppressive roles in emergency monopoiesis. Overall, our study established a systemic bacterial infection model that led to emergency myelopoiesis, thereby improving our understanding of the function of Pu.1 in this scenario.
Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer
Authors: Li Shuqin , Cao Jian , Zhang Wei , Zhang Fan , Ni Guantai , Luo Qian , Wang Man , Tao Xiang , Xia Hongping 
Published: November 2016

AbstractThe current standard treatment for ovarian cancer is aggressive surgery followed by platinum-based combination chemotherapy. Recurrence and chemotherapeutic drug resistance are the two main factors that account for the high mortality of most ovarian cancers. Liposomal doxorubicin is primarily used for the treatment of ovarian cancer when the disease has progressed after platinum-based chemotherapy. However, relatively little is known about the genomic changes that contribute to both cisplatin and doxorubicin resistance in high-grade serous ovarian cancer (HGSC) under the selective pressure of chemotherapy. Here, we found that protein tyrosine phosphatase PTPN3 gene expression was substantially increased in both cisplatin and doxorubicin-resistant ovarian cancer cells. Silencing of PTPN3 restored sensitivity to cisplatin and doxorubicin in resistant ovarian cancer cells. Down-regulation of PTPN3 also inhibited cell cycle progression, migration, stemness in vitro and the tumorigenicity of resistant ovarian cancer cells in vivo. Meanwhile, the expression of PTPN3 was found to be regulated by miR-199 in resistant ovarian cancer cells. These findings suggest that PTPN3 promotes tumorigenicity, stemness and drug resistance in ovarian cancer, and thus is a potential therapeutic target for the treatment of ovarian cancer.