bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Analysis of Centrifugal Pumps Running in Turbine Mode Under Dynamic Operating Conditions
Authors: De Rose Vincenzo , Martelli Francesca , Milani Massimo , Montorsi Luca 
Published: August 2017

The use of pumps as turbines (PAT) has gained importance in the recent years as a possible alternative to specifically developed turbine for mini/micro hydropower plants. The use of production pump for hydropower generation reduces the capital cost of the plant but the energy conversion efficiency can be remarkably lower.
The paper analyses the performance of a production centrifugal pump running both in direct and reverse mode. The analysis calculates theoretically the behavior of the PAT under the best efficiency point and extends the investigation to other operating points using both a combined theoretical approach and CFD simulation under dynamic conditions.
The effects of possible modifications to the initial design of the pump are investigated when running in turbine mode and their influence on the standard pump operation is also determined.
Numerical simulation demonstrates that the impeller trimming leads to improvement in the PAT efficiency in some operating conditions. Conversely, the rotational speeds close to the values typical for the electric generator reduce the PAT performance. Finally, the modification of the impeller geometry at the turbine inlet increases the PAT efficiency but lowers the performance of the machine when running in pump mode.
Development of a Fiber-Optic Hybrid Day-Lighting System for Mobile Shelter Applications
Authors: Lawless Sean , Gorthala Ravi 
Published: August 2017

This paper discusses a Fiber-Optic Hybrid Day-Lighting system that can cut energy consumed by buildings for lighting significantly. This system is designed for mobile applications such as military shelters. The system is comprised of two primary components: the solar collector and the Solar Hybrid Lighting Fixture. The first component, the solar collector, consists of a housing, structural stand, a dual axis tracking system, Fresnel Lenses, secondary optics, and fiber-optic cables. The collector is integrated into a dual-axis tracker, which is then mounted on a tripod. The tripod can be staked into the ground and weighed down to protect the system from any wind loading and the collector height can be adjusted so that there is no shading of the collector by nearby structures. The collector with an aluminum housing holds eight 10-inch diameter Fresnel Lenses that focus sunlight onto eight secondary optics based on TIR (total internal reflection) which filter UV/IR and deliver uniform light to the fiber-optic cables. The secondary optic is coupled to the fiber-optic cable with index matching gel so that Fresnel reflection losses are minimized. The solar collector tracks the sun’s movement through the day with a dual-axis tracker (azimuth/tilt), ensuring the light is concentrated into the fiber-optic cables. The optics has been designed to have a high half-acceptance of 1.75° and can accommodate a tracking accuracy of 1.50° or better.
The opposite end of the fiber-optic cable attaches to the second part of the Day-Lighting system, the Solar Hybrid Light Fixture (SHLF). The SHLF comprises of two lighting systems: 1) a solar fiber-optic system and 2) an LED system. The fiber-optic cable is coupled to an acrylic light diffusing rod that evenly delivers the light into the room. During sunny periods, depending on the length of the cable, solar fiber-optic lighting could provide full illumination of the space. In order to keep lighting uniform even during fluctuations of the light output from the sun during cloudy periods, the LED portion of the light will allow for constant lighting at a lower power consumption. The LED lighting has dimming capabilities due to a photosensor that regulates the light output of the LEDs based on how much solar light is delivered by the fiber-optic cables. On a typical sunny day with an overall concentration factor of ∼400 from the Fresnel Lens system to the optical fiber, it is possible to generate an output of 2,000 lumens with a 20-foot cable, with each fiber-optic cable experiencing a 1% loss of light per foot of cable. The LED portion of the hybrid light fixture produces about 1,800 lumens as well.
Evaluation of a Prototype Integrated Solar Combined-Cycle Power Plant Using a Linear Fresnel Reflector
Authors: Altmann Fernando , Cheng A. S. (Ed) 
Published: August 2017

A computational heat-transfer and thermodynamic-cycle model was developed to evaluate the performance of an integrated solar and combined-cycle power plant using a prototype linear Fresnel reflector. The solar receiver consists of a secondary reflector and single-tube absorber, with a selective surface and glass cover to optimize collector efficiency. The solar integration occurs in the high-pressure steam drum of the heat recovery steam generator, to boost power output when solar energy is available without the need for an auxiliary fossil-fueled boiler or thermal storage. The solar resource and weather data used in the model were for the municipality of Bom Jesus da Lapa, Brazil.
Results indicated that, over a year, 8.25 GWh of solar thermal energy was provided to the plant, with an incremental power plant output of 2.76 GWh. While these numbers were small relative to baseline power plant operation using only fossil-fuel sources, the utilization of additional solar thermal modules would produce a more significant impact.
Complete Genome Sequence of
Magnetospirillum
sp. ME-1, a Novel Magnetotactic Bacterium Isolated from East Lake, Wuhan, China
Authors: Ke Linfeng , Liu Pengming , Liu Shan , Gao Meiying 
Published: August 2017

ABSTRACT

A novel spiral magnetotactic bacterium,
Magnetospirillum
sp. ME-1, was isolated from East Lake in China. Here we report the complete genome of ME-1, which contains a 4,551,873-bp circular chromosome and a 5,222-bp circular plasmid. The magnetosome biogenesis-specific genes are located in a 97,664-bp magnetosome genomic island.
Draft Genome Sequence of a Methicillin-Resistant Staphylococcus aureus Isolate (Sequence Type 1) from Seafood
Authors: Sivaraman G. K. , Vanik Deesha , Visnuvinayagam S. , Prasad M. M. , Ravishankar C. N. 
Published: August 2017

ABSTRACT

The draft genome sequence of a methicillin-resistant
Staphylococcus aureus
(MRSA) isolate (sequence type 1 [ST 1]) from the salted dried ribbonfish from Gujarat, India, is reported here.
Staphylococcus
genus-specific genes were present in this MRSA isolate. The whole-genome sequence of this strain contains 2,797 protein-coding genes and 80 RNAs within the 2.85-Mb genome.
Complete Genome Characterization of the Porcine Deltacoronavirus HKD/JPN/2016, Isolated in Japan, 2016
Authors: Suzuki Tohru , Hayakawa Jun , Ohashi Seiichi 
Published: August 2017

ABSTRACT
In 2016, an outbreak of diarrhea with high mortality in piglets occurred on a swine farm in Hokkaido prefecture, Japan. The causative porcine deltacoronavirus HDK/JPN/2016 was isolated from intestinal samples of the dead piglets on LLC-PK1 cells. The complete genome of HKD/JPN/2016 was sequenced and analyzed by next-generation sequencing technology.
Draft Genome Sequence of the Fungus Associated with Oak Wilt Mortality in South Korea,
Raffaelea quercus-mongolicae
KACC44405
Authors: Jeon Jongbum , Kim Ki-Tae , Song Hyeunjeong , Lee Gir-Won , Cheong Kyeongchae , Kim Hyunbin , Choi Gobong , Lee Yong-Hwan , Stewart Jane E. , Klopfenstein Ned B. , Kim Mee-Sook 
Published: August 2017

ABSTRACT

The fungus
Raffaelea quercus-mongolicae
is the causal agent of Korean oak wilt, a disease associated with mass mortality of oak trees (e.g.,
Quercus
spp.). The fungus is vectored and dispersed by the ambrosia beetle,
Platypus koryoensis
. Here, we present the 27.0-Mb draft genome sequence of
R. quercus-mongolicae
strain KACC44405.
Complete Genome Sequence of
Streptomyces
sp. TN58, a Producer of Acyl Alpha-
l
-Rhamnopyranosides
Authors: Najah Soumaya , Chong Teik Min , Gerbaud Claude , Chan Kok-Gan , Mellouli Lotfi , Pernodet Jean-Luc 
Published: August 2017

ABSTRACT

Streptomyces
sp. TN58, isolated from a Tunisian soil sample, produces several natural products, including acyl alpha-
l
-rhamnopyranosides. It possesses a 7.6-Mb linear chromosome. This is, to our knowledge, the first genome sequence of a microorganism known to produce acyl alpha-
l
-rhamnopyranosides, and it will be helpful to study the biosynthesis of these specialized metabolites.
Complete Genome Sequence of a Novel Human Gammapapillomavirus Isolated from Skin
Authors: Brancaccio Rosario N. , Robitaille Alexis , Dutta Sankhadeep , Rollison Dana E. , Fischer Nicole , Grundhoff Adam , Tommasino Massimo , Gheit Tarik 
Published: August 2017

ABSTRACT
A novel human papillomavirus (HPV ICB1) was fully characterized from a skin swab by using a sensitive degenerate PCR protocol combined with next-generation sequencing. The L1 open reading frame of HPV ICB1 shares 70.54% nucleotide homology with its closest relative, HPV164, and thus constitutes a novel human gammapapillomavirus.
Bacteriophage Clinical Use as Antibacterial “Drugs”: Utility and Precedent
Authors: Abedon Stephen T. 
Published: August 2017

ABSTRACT
For phage therapy—the treatment of bacterial infections using bacterial viruses—a key issue is the conflict between apparent ease of clinical application, on the one hand, and on the other hand, numerous difficulties that can be associated with undertaking preclinical development. These conflicts between achieving efficacy in the real world versus rigorously understanding that efficacy should not be surprising because equivalent conflicts have been observed in applied biology for millennia: exploiting the inherent, holistic tendencies of useful systems, e.g., of dairy cows, inevitably is easier than modeling those systems or maintaining effectiveness while reducing such systems to isolated parts. Trial and error alone, in other words, can be a powerful means toward technological development. Undertaking trial and error-based programs, especially in the clinic, nonetheless is highly dependent on those technologies possessing both inherent safety and intrinsic tendencies toward effectiveness, but in this modern era we tend to forget that ideally there would exist antibacterials which could be thus developed, that is, with tendencies toward both safety and effectiveness, and which are even relatively inexpensive. Consequently, we tend to demand rigor as well as expense of development even to the point of potentially squandering such utility, were it to exist. In this review I lay out evidence that in phage therapy such potential, in fact, does exist. Advancement of phage therapy unquestionably requires effective regulation as well as rigorous demonstration of efficacy, but after nearly 100 years of clinical practice, perhaps not as much emphasis on strictly laboratory-based proof of principle.
Out-of-hospital sudden cardiac arrest in children with congenital heart defects
Authors: Jortveit Jarle , Klcovansky Jakob , Døhlen Gaute , Eskedal Leif , Birkeland Sigurd , Holmstrøm Henrik 
Published: August 2017

AimsOut-of-hospital sudden cardiac arrest (SCA) is a rare but devastating event in children and adolescents. The risk is assumed to be higher in children with congenital heart defects (CHDs) than in healthy individuals. The aim of the present study was to investigate the rate of and survival after out-of-hospital cardiac arrest in children 2–18 years old with CHDs.Methods and resultsData concerning all live births in Norway between 1994 and 2009 were retrieved from the Medical Birth Registry of Norway, the patient administrative systems at all hospitals in Norway, the Oslo University Hospital’s Clinical Registry for Congenital Heart Defects and the Norwegian Cause of Death Registry. Survivors were followed through 2012, and supplementary information for the deceased children was retrieved from medical records at Norwegian hospitals. Among the 943 871 live births in Norway from 1994 to 2009, 11 272 (1.2%) children had a CHD. We identified 11 (0.1%) children 2–18 years old with CHDs who experienced out-of-hospital SCA. The estimated rate of out-of-hospital SCA in children 2–18 years old with CHD was 10 per 100 000 person-years. Early cardiopulmonary resuscitation was initiated in all patients. Three children survived.ConclusionsThe incidence of and survival after out-of-hospital SCA in children with CHDs were comparable to the reported rates in the general child population.
Concurrent validity, discriminatory power and feasibility of the instrument for Identification of Parents At Risk for child Abuse and Neglect (IPARAN)
Authors: Horrevorts Esther M B , van Grieken Amy , Mieloo Cathelijne L , Hafkamp-de Groen Esther , Bannink Rienke , Bouwmeester-Landweer Merian B R , Broeren Suzanne , Raat Hein 
Published: August 2017

ObjectivesTo determine the feasibility, concurrent validity and discriminatory power of the instrument for Identification of Parents At Risk for child Abuse and Neglect (IPARAN) among Dutch parents with a newborn child.SettingCommunity paediatrics.ParticipantsData from a controlled trial were used. In total, 2659 Dutch parents with a newborn child were invited to participate. Of the 2659 parents, 759 parents filled in the consent form and participated in the study.Primary and secondary outcome measuresConcurrent validity was determined by calculating correlations—using the Pearson’s correlation (r)—between the IPARAN score and related constructs from the following instruments: the Empowerment Questionnaire 2.0, the Family Functioning Questionnaire and the Parenting Stress Questionnaire. Discriminatory power was determined by calculating receiver operating characteristic (ROC) curves between high-risk mothers and low-risk mothers according to their scores on the related constructs. Feasibility was determined by examining the percentage of missing answers.ResultsIn terms of concurrent validity, we found that 3 out of 12 correlations between the IPARAN score and related constructs were strong (ie, r>0.50) and 4 out of 12 were medium (ie, r=0.30–0.49). In terms of discriminatory power, mothers with a score in the borderline/clinical range or lowest 10 percent (P10) range of the related constructs (high-risk mothers) had a higher IPARAN score than mothers with a score in the normal range or highest 90 percent (P90) range of the related constructs (low-risk mothers). Effect sizes varied from d=0.37 to d=1.93, and the area under the ROC curve varied from 0.62 to 0.93. Regarding feasibility, the part of the IPARAN filled in by the mother had on average 0.7% missing answers, whereas the part of the IPARAN filled in by the father had on average 1.7% missing answers.ConclusionThe results of this study support the concurrent validity, discriminatory power and feasibility of the IPARAN among a population of Dutch parents with a newborn child.
Impact of family-friendly prison policies on health, justice and child protection outcomes for incarcerated mothers and their dependent children: a cohort study protocol
Authors: Myers Helen , Segal Leonie , Lopez Derrick , Li Ian W , Preen David B 
Published: August 2017

IntroductionFemale imprisonment has numerous health and social sequelae for both women prisoners and their children. Examples of comprehensive family-friendly prison policies that seek to improve the health and social functioning of women prisoners and their children exist but have not been evaluated. This study will determine the impact of exposure to a family-friendly prison environment on health, child protection and justice outcomes for incarcerated mothers and their dependent children.Methods and analysisA longitudinal retrospective cohort design will be used to compare outcomes for mothers incarcerated at Boronia Pre-release Centre, a women’s prison with a dedicated family-friendly environment, and their dependent children, with outcomes for mothers incarcerated at other prisons in Western Australia (that do not offer this environment) and their dependent children. Routinely collected administrative data from 1985 to 2013 will be used to determine child and mother outcomes such as hospital admissions, emergency department presentations, custodial sentences, community service orders and placement in out-of home care. The sample consists of all children born in Western Australia between 1 January 1985 and 31 December 2011 who had a mother in a West Australian prison between 1990 and 2012 and their mothers. Children are included if they were alive and aged less than 18 years at the time of their mother’s incarceration. The sample comprises an exposed group of 665 women incarcerated at Boronia and their 1714 dependent children and a non-exposed comparison sample of 2976 women incarcerated at other West Australian prisons and their 7186 dependent children, creating a total study sample of 3641 women and 8900 children.Ethics and disseminationThis project received ethics approval from the Western Australian Department of Health Human Research Ethics Committee, the Western Australian Aboriginal Health Ethics Committee and the University of Western Australia Human Research Ethics Committee.
Exploring the enablers and barriers to implementing the Medication Appropriateness Tool for Comorbid Health conditions during Dementia (MATCH-D) criteria in Australia: a qualitative study
Authors: Page Amy Theresa , Clifford Rhonda Marise , Potter Kathleen , Seubert Liza , McLachlan Andrew J , Hill Xaysja , King Stephanie , Clark Vaughan , Ryan Cristin , Parekh Nikesh , Etherton-Beer Christopher D 
Published: August 2017

ObjectivesThe Medication Appropriateness Tool for Comorbid Health conditions in Dementia (MATCH-D) criteria provide expert consensus guidance about medication use for people with dementia. This study aimed to identify enablers and barriers to implementing the criteria in practice.SettingParticipants came from both rural and metropolitan communities in two Australian states.ParticipantsFocus groups were held with consumers, general practitioners, nurses and pharmacists. Outcomes: data were analysed thematically.ResultsNine focus groups were conducted. Fifty-five participants validated the content of MATCH-D, appraising them as providing patient-centred principles of care. Participants identified potential applications (including the use of MATCH-D as a discussion aid or educational tool for consumers about medicines) and suggested supporting resources.ConclusionParticipants provided insights into applying MATCH-D in practice and suggested resources to be included in an accompanying toolkit. These data provide external validation of MATCH-D and an empiric basis for their translation to practice. Following resource development, we plan to evaluate the feasibility and efficacy of implementation in practice.
Alcohol consumption in a general antenatal population and child neurodevelopment at 2 years
Authors: Halliday Jane L , Muggli Evelyne , Lewis Sharon , Elliott Elizabeth J , Amor David J , O’Leary Colleen , Donath Susan , Forster Della , Nagle Cate , Craig Jeffrey M , Anderson Peter J 
Published: August 2017

BackgroundPrenatal alcohol exposure (PAE) is a community health problem with up to 50% of pregnant women drinking alcohol. The relationship between low or sporadic binge PAE and adverse child outcomes is not clear. This study examines the association between PAE in the general antenatal population and child neurodevelopment at 2 years, accounting for relevant contributing factors.MethodsThis prospective population-based cohort recruited 1570 pregnant women, providing sociodemographic, psychological and lifestyle information and alcohol use for five time periods. PAE categories were ‘low’, ‘moderate/high’, ‘binge’, in trimester 1 or throughout pregnancy. Measures of cognitive, language and motor development (Bayley Scales of Infant and Toddler Development) were available for 554 children, while measures of sensory processing (Infant/Toddler Sensory Profile) and social–emotional development (Brief Infant Toddler Social Emotional Assessment) were available for 948.ResultsA positive association in univariate analysis with low-level PAE throughout pregnancy and cognition (β=4.1, 95% CI −0.02 to 8.22, p=0.05) was attenuated by adjusting for environmental/social deprivation risk factors (β=3.06 (−1.19 to 7.30), p=0.16). Early binge drinking, plus continued PAE at lower levels, was associated with the child being more likely to score low in sensation avoidance (adjusted OR 1.88 (1.03 to 3.41), p=0.04).ConclusionEarly binge exposure, followed by lower-level PAE, demonstrated an increase in sensation-avoiding behaviour. There were, however, no significant associations between PAE and neurodevelopment following adjustment for important confounders and modifiers. Follow-up is paramount to investigate subtle or later onset problems.
Cancer Self-Defense: An Immune Stealth
Authors: Nakajima Kosei , Nangia-Makker Pratima , Hogan Victor , Raz Avraham 
Published: August 2017

Abstract
The hurdles in realizing successful cancer immunotherapy stem from the fact that cancer patients are either refractory to immune response and/or develop resistance. Here, we propose that these phenomena are due, in part, to the deployment/secretion of a “decoy flare,” for example, anomalous cancer-associated antigens by the tumor cells. The cancer secretome, which resembles the parent cell make-up, is composed of soluble macromolecules (proteins, glycans, lipids, DNAs, RNAs, etc.) and insoluble vesicles (exosomes), thus hindering cancer detection/recognition by immunotherapeutic agents, resulting in a “cancer-stealth” effect. Immunotherapy, or any treatment that relies on antigens' expression/function, could be improved by the understanding of the properties of the cancer secretome, as its clinical evaluation may change the therapeutic landscape. Cancer Res; 77(20); 5441–4. ©2017 AACR.
The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors
Authors: Harney Allison S. , Karagiannis George S. , Pignatelli Jeanine , Smith Bryan D. , Kadioglu Ece , Wise Scott C. , Hood Molly M. , Kaufman Michael D. , Leary Cynthia B. , Lu Wei-Ping , Al-Ani Gada , Chen Xiaoming , Entenberg David , Oktay Maja H. , Wang Yarong , Chun Lawrence , De Palma Michele , Jones Joan G. , Flynn Daniel L. , Condeelis John S. 
Published: August 2017

AbstractTumor-infiltrating myeloid cells promote tumor progression by mediating angiogenesis, tumor cell intravasation, and metastasis, which can offset the effects of chemotherapy, radiation, and antiangiogenic therapy. Here, we show that the kinase switch control inhibitor rebastinib inhibits Tie2, a tyrosine kinase receptor expressed on endothelial cells and protumoral Tie2-expressing macrophages in mouse models of metastatic cancer. Rebastinib reduces tumor growth and metastasis in an orthotopic mouse model of metastatic mammary carcinoma through reduction of Tie2+ myeloid cell infiltration, antiangiogenic effects, and blockade of tumor cell intravasation mediated by perivascular Tie2Hi/Vegf-AHi macrophages in the tumor microenvironment of metastasis (TMEM). The antitumor effects of rebastinib enhance the efficacy of microtubule inhibiting chemotherapeutic agents, either eribulin or paclitaxel, by reducing tumor volume, metastasis, and improving overall survival. Rebastinib inhibition of angiopoietin/Tie2 signaling impairs multiple pathways in tumor progression mediated by protumoral Tie2+ macrophages, including TMEM-dependent dissemination and angiopoietin/Tie2-dependent angiogenesis. Rebastinib is a promising therapy for achieving Tie2 inhibition in cancer patients. Mol Cancer Ther; 16(11); 2486–501. ©2017 AACR.