bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF TREE-TO-TREE YIELD VARIABILITY AMONG SEEDLING-BASED CACAO POPULATIONS IN AN INDUSTRIAL PLANTATION IN CÔTE D'IVOIRE
Authors: WIBAUX THOMAS , KONAN DANY-CLAUDE , SNOECK DIDIER , JAGORET PATRICK , BASTIDE PHILIPPE 
Published: July 2017

SUMMARYIn Côte d'Ivoire, the world's largest cocoa producer, cacao (Theobroma cacaoL.) is usually grown from seed. The genetics consist of a mix of amelonado, trinitario and selected hybrids. This mix of varieties generates high phenotypic variabilities, including variability in tree productivity, within cacao populations in both smallholder and industrial plantations. Tree-to-tree variability in yield has been reported in cacao breeding trials under different environmental conditions. However, it has never been considered a limiting factor for agronomical performance of seedling-based cacao plantations. Around 10 000 cacao trees from seven plots under different environmental conditions in a cacao plantation in Côte d'Ivoire were monitored for 2 years. Pod production of individual trees was recorded and annual average tree pod yields were assessed. High heterogeneity in cacao-tree yields was observed in all plots, with coefficients of variation ranging from 56 to 102%. The distribution of cacao-tree yields in each plot was positively skewed. Analysis of these distributions showed that unproductive trees represented a significant proportion of cacao tree populations (7%), and the 20% least productive trees accounted for 3% of production. The 20% most productive trees were responsible for 46% of the total pod production of a plot. This heterogeneity reflects a major imbalance in the agronomical performances of low- and high-yielding trees and also represents possible efficiency gaps in seedling-based cacao plantations, which could be overcome through innovative corrective strategies, opening new pathways for improvement of cacao-based cropping systems.
Cumulative exposure to childhood adversity, and treated attention deficit/hyperactivity disorder: a cohort study of 543 650 adolescents and young adults in Sweden
Authors: Björkenstam E. , Björkenstam C. , Jablonska B. , Kosidou K. 
Published: July 2017

BackgroundThough childhood adversity (CA) has been associated with the risk of attention deficit/hyperactivity disorder (ADHD), little is known about the effect of cumulative CAs and whether there are clusters of CAs that are more closely related with ADHD.MethodsWe used a Swedish cohort of 543 650 individuals born 1987–1991. Register-based CAs included familial death, substantial parental substance abuse and psychiatric disorder, substantial parental criminality, parental separation, household public assistance recipiency, and residential instability. Individuals were followed from year 2006 when they were 15–19 years of age, for treated ADHD, defined as a registered ICD diagnosis and/or prescription of medications to treat ADHD. Logistic regression analysis was used to calculate odds ratios (OR) with 95% confidence intervals (CI). Latent Class Analyses (LCA) were used to identify clusters based on the different CAs.ResultsAll CAs increased the odds of ADHD in late adolescence and early adulthood; ORs ranged from 1.6 (95% CI 1.5–1.8) for familial death to 2.7 (95% CI 2.6–2.9) for household public assistance. We found a dose-response relationship between cumulative CA and ADHD; individuals with 4+ CAs had a markedly increased risk for ADHD (OR 5.5, 95% CI 5.0–6.0). LCA analyses revealed six distinct classes of CA associated with ADHD, of which ‘exposure to most adversities’ entailed highest risk.ConclusionCA is a strong risk factor for ADHD, particularly when accumulated. Early and efficient detection of CA is of importance for interventions targeted to improve long-term mental health outcomes among disadvantaged children.
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
Authors:   Eating Disorder Working Group of the Psychiatric Genomics Consortium, Huckins L M , Hatzikotoulas K , Southam L , Thornton L M , Steinberg J , Aguilera-McKay F , Treasure J , Schmidt U , Gunasinghe C , Romero A , Curtis C , Rhodes D , Moens J , Kalsi G , Dempster D , Leung R , Keohane A , Burghardt R , Ehrlich S , Hebebrand J , Hinney A , Ludolph A , Walton E , Deloukas P , Hofman A , Palotie A , Palta P , van Rooij F J A , Stirrups K , Adan R , Boni C , Cone R , Dedoussis G , van Furth E , Gonidakis F , Gorwood P , Hudson J , Kaprio J , Kas M , Keski-Rahonen A , Kiezebrink K , Knudsen G-P , Slof-Op 't Landt M C T , Maj M , Monteleone A M , Monteleone P , Raevuori A H , Reichborn-Kjennerud T , Tozzi F , Tsitsika A , van Elburg A , Collier D A , Sullivan P F , Breen G , Bulik C M , Zeggini E 
Published: July 2017

AbstractAnorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward forin silicoandde novoreplication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant inOPCML(P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
Comparative conventional and phenomics approaches to assess symbiotic effectiveness of Bradyrhizobia strains in soybean (Glycine max L. Merrill) to drought
Authors: Govindasamy Venkadasamy , George Priya , Aher Lalitkumar , Ramesh Shunmugiah V. , Thangasamy Arunachalam , Anandan Sivalingam , Raina Susheel Kumar , Kumar Mahesh , Rane Jagadish , Annapurna Kannepalli , Minhas Paramjit Singh 
Published: July 2017

AbstractSymbiotic effectiveness of rhizobitoxine (Rtx)-producing strains of Bradyrhizobium spp. in soybean (cultivar NRC-37/Ahilya-4) under limited soil moisture conditions was evaluated using phenomics tools such as infrared(IR) thermal and visible imaging. Red, green and blue (RGB) colour pixels were standardized to analyse a total of 1017 IR thermal and 692 visible images. Plants inoculated with the Rtx-producing strains B. elkanii USDA-61 and USDA-94 and successive inoculation by B. diazoefficiens USDA-110 resulted in cooler canopy temperatures and increased canopy greenness. The results of the image analysis of plants inoculated with Rtx-producing strains were correlated with effective nodulation, improved photosynthesis, plant nitrogen status and yield parameters. Principal component analysis (PCA) revealed the reliability of the phenomics approach over conventional destructive approaches in assessing the symbiotic effectiveness of Bradyrhizobium strains in soybean plants under watered (87.41–89.96%) and water-stressed (90.54–94.21%) conditions. Multivariate cluster analysis (MCA) revealed two distinct clusters denoting effective (Rtx) and ineffective (non-Rtx) Bradyrhizobium inoculation treatments in soybean. Furthermore, correlation analysis showed that this phenotyping approach is a dependable alternative for screening drought tolerant genotypes or drought resilience symbiosis. This is the first report on the application of non-invasive phenomics techniques, particularly RGB-based image analysis, in assessing plant-microbe symbiotic interactions to impart abiotic stress tolerance.
Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
Authors: Saunier Elise , Antonio Samantha , Regazzetti Anne , Auzeil Nicolas , Laprévote Olivier , Shay Jerry W. , Coumoul Xavier , Barouki Robert , Benelli Chantal , Huc Laurence , Bortoli Sylvie 
Published: July 2017

AbstractResveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in the prevention of tumor growth. However, the rapid metabolism of resveratrol strongly limits its bioavailability. The molecular mechanisms sustaining the potential biological activity of low doses of resveratrol has not been extensively studied and, thus, needs better characterization. Here, we show that resveratrol (10 µM, 48 hr) induces both a cell growth arrest and a metabolic reprogramming in colon cancer cells. Resveratrol modifies the lipidomic profile, increases oxidative capacities and decreases glycolysis, in association with a decreased pentose phosphate activity and an increased ATP production. Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced PDH activity. Calcium chelation, as well as the blockade of the mitochondrial calcium uniport, prevents the resveratrol-induced augmentation in oxidative capacities and the increased PDH activity suggesting that calcium might play a role in the metabolic shift. We further demonstrate that the inhibition of the CamKKB or the downstream AMPK pathway partly abolished the resveratrol-induced increase of glucose oxidation. This suggests that resveratrol might improve the oxidative capacities of cancer cells through the CamKKB/AMPK pathway.
Genomewide Analysis of Clp1 Function in Transcription in Budding Yeast
Authors: Al-Husini Nadra , Sharifi Ali , Mousavi Seyed Ahmad , Chitsaz Hamidreza , Ansari Athar 
Published: July 2017

AbstractIn budding yeast, the 3′ end processing of mRNA and the coupled termination of transcription by RNAPII requires the CF IA complex. We have earlier demonstrated a role for the Clp1 subunit of this complex in termination and promoter-associated transcription of CHA1. To assess the generality of the observed function of Clp1 in transcription, we tested the effect of Clp1 on transcription on a genomewide scale using the Global Run-On-Seq (GRO-Seq) approach. GRO-Seq analysis showed the polymerase reading through the termination signal in the downstream region of highly transcribed genes in a temperature-sensitive mutant of Clp1 at elevated temperature. No such terminator readthrough was observed in the mutant at the permissive temperature. The poly(A)-independent termination of transcription of snoRNAs, however, remained unaffected in the absence of Clp1 activity. These results strongly suggest a role for Clp1 in poly(A)-coupled termination of transcription. Furthermore, the density of antisense transcribing polymerase upstream of the promoter region exhibited an increase in the absence of Clp1 activity, thus implicating Clp1 in promoter directionality. The overall conclusion of these results is that Clp1 plays a general role in poly(A)-coupled termination of RNAPII transcription and in enhancing promoter directionality in budding yeast.
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system
Authors: Sato Keisuke , Takahashi Naoki , Kato Tamotsu , Matsuda Yumi , Yokoji Mai , Yamada Miki , Nakajima Takako , Kondo Naoki , Endo Naoto , Yamamoto Reiko , Noiri Yuichiro , Ohno Hiroshi , Yamazaki Kazuhisa 
Published: July 2017

AbstractPorhyromonas gingivalis, a causative bacterium of periodontitis, is implicated in the etiology of rheumatoid arthritis (RA), mainly because of expressing peptidyl arginine deiminase (PAD) that generates RA-related autoantigens. However, compared with other periodontopathic bacteria, the precise role of P. gingivalis in RA is largely unknown. We found that orally administered P. gingivalis changed the gut microbiome with concomitant elevation of serum endotoxin and inflammatory markers, and impairment of the gut barrier function. Based on findings showing a relationship between gut microbiota and RA, we investigated whether the change of gut microbiota induced by P. gingivalis and Prevotella intermedia, another periodontopathic bacterium without PAD, is associated with collagen-induced arthritis (CIA). DBA/1J mice were orally administered with or without bacteria followed by induction of CIA. P. gingivalis, but not P. intermedia, administration significantly aggravated arthritis with increased interleukin-17 levels in sera and culture supernatants, increased Th17 cell proportions among mesenteric lymphocytes, and a significant change in the gut microbiome. However, P. gingivalis administration did not elevate the level of anti-citrullinated protein antibody. These results suggest a unique role of P. gingivalis in the link between periodontitis and RA by affecting the gut immune system and the gut microbiota composition.
IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice
Authors: Shintani Yusuke , Ito Tomoya , Fields Laura , Shiraishi Manabu , Ichihara Yuki , Sato Nobuhiko , Podaru Mihai , Kainuma Satoshi , Tanaka Hiroyuki , Suzuki Ken 
Published: July 2017

AbstractRecent research has shown that reparative (alternatively activated or M2) macrophages play a role in repair of damaged tissues, including the infarcted hearts. Administration of IL-4 is known to augment M2 macrophages. This translational study thus aimed to investigate whether IL-4 administration is useful for the treatment of myocardial infarction. Long-acting IL-4 complex (IL-4c; recombinant IL-4 mixed with anti-IL-4 monoclonal antibody as a stabilizer) was administered after coronary artery ligation in mice. It was observed that IL-4c administration increased accumulation of CD206+F4/80+ M2-like macrophages predominantly in the injured myocardium, compared to the control. Sorted cardiac M2-like macrophages highly expressed wide-ranging tissue repair-related genes. Indeed, IL-4c administration enhanced cardiac function in association with reduced infarct size and enhanced tissue repair (strengthened connective tissue formation, improved microvascular formation and attenuated cardiomyocyte hypertrophy). Experiments using Trib1−/− mice that had a depleted ability to develop M2 macrophages and other in-vitro studies supported that these IL-4-mediated effects were induced via M2-like macrophages. On the other hand, when administered at Day 28 post-MI, the effects of IL-4c were diminished, suggesting a time-frame for IL-4 treatment to be effective. These data represent proof-of-concept of efficacy of IL-4 treatment for acute myocardial infarction, encouraging its further development.
Early life-history predator-prey reversal in two cyprinid fishes
Authors: Šmejkal Marek , Baran Roman , Blabolil Petr , Vejřík Lukáš , Prchalová Marie , Bartoň Daniel , Mrkvička Tomáš , Kubečka Jan 
Published: July 2017

AbstractPredator-prey relationships are often perceived simply as a situation in which a predator enhances its own fitness while reducing the fitness of its prey. However, this relationship may become reversed when the prey feeds on the juvenile predator stages. We investigated this phenomenon in a model asp (Leuciscus aspius; predator)-bleak (Alburnus alburnus; prey) relationship. The adhesive asp eggs are available for bleak predation after a spawning event for only tens of seconds before they adhere to the stones, where bleak do not forage. Gut content analysis demonstrated that eggs were utilized in high quantities, especially in the spawning peak of the asp reproductive season. Furthermore, using underwater video, we recorded the bleak feeding efficiency on naturally drifting asp eggs as the percentage of eggs eaten. Within the 40 cm egg trajectory captured by our cameras, total egg mortality was 21.2 ± 2.2% on average. The highest survival chances occurred among eggs drifting in aggregations, since the short drifting distance together with their aggregated distribution satiated bleak and part of the egg aggregation could attach to the spawning ground. This study emphasizes the potential efficiency of predator egg utilization by prey, which may have further consequences in predator-prey dynamics.
Corn-like, recoverable γ-Fe2O3@SiO2@TiO2 photocatalyst induced by magnetic dipole interactions
Authors: Wang Fang , Li Manhong , Yu Lifang , Sun Fan , Wang Zhuliang , Zhang Lifang , Zeng Hao , Xu Xiaohong 
Published: July 2017

AbstractCorn-like, γ-Fe2O3@SiO2@TiO2 core/shell heterostructures were synthesized by a modified solvothermal reduction combined with a sol-gel method. SiO2 shells were first deposited on monodisperse Fe3O4 microspheres by a sol-gel method. Fe3O4@SiO2@TiO2 corn-like heterostructures were then obtained by sequential TiO2 coating, during which the magnetic dipolar interactions induced the anisotropic self-assembly process. After annealing at 350 °C, the crystalized TiO2 enhanced photocatalytic activity, while Fe3O4 was converted to γ-Fe2O3. The corn-like γ-Fe2O3@SiO2@TiO2 photocatalyst can be recycled and reused by magnet extraction. Despite the photocatalytic activity decreased with each cycle, it can be completely recovered by moderate heating at 200 °C.
Iterative reconstruction improves detection of in-stent restenosis by high-pitch dual-source coronary CT angiography
Authors: Yang Junjie , Yang Xiaobo , De Cecco Carlo N. , Duguay Taylor M. , Chen Zhiye , Tesche Christian , Schoepf U. Joseph , Chen Yundai 
Published: July 2017

AbstractRecent studies demonstrated that sinogram affirmed iterative reconstructions (SAFIRE) can produce higher-resolution images with greater robustness for the reduction of various imaging artefacts. Eighty-five patients were prospectively evaluated and underwent a high-pitch spiral acquisition CT scan. In-stent noise, signal-to-noise ratio(SNR), stent-lumen attenuation increase ratio (SAIR), and subjective image quality score were measured and compared between the SAFIRE and Filter back projection (FBP) reconstructions. Conventional coronary angiography served as the standard of reference. In 159 evaluated stents, SAFIRE was superior to FBP with regards to in-stent noise, SNR, SAIR, and image quality score. On per-stent analysis, SAFIRE vs. FBP reconstruction yielded 85% vs. 85%sensitivity, 89% vs. 78%specificity, 73% vs. 57%positive predictive value, 95% vs. 94%negative predictive value, and 0.87 vs. 0.82 area under curve, although these improvements did not reach statistical significance (P > 0.05). However, in the subgroup of small diameter stents (≤3 mm; n = 95), specificity(82% vs. 62%), positive predictive value(66% vs. 50%) and area under curve (0.81 vs. 0.70) improved significantly (P < 0.05) with SAFIRE. SAFIRE image reconstruction can thus improve the evaluation for ISR, especially in smaller stents.
Aneurysms of the Intracranial Segment of the Ophthalmic Artery Trunk: Case Report and Systematic Literature Review
Authors: Biraschi Francesco , Diana Francesco , Colonnese Claudio , Marenco Marco , Delfini Roberto , Peschillo Simone 
Published: July 2017

AbstractAneurysms arising from the ophthalmic artery trunk (OAT) are very rare, particularly in the artery's intracranial course. The onset of a subarachnoid hemorrhage (SAH) from a ruptured OAT aneurysm in this segment is extremely rare. We present a case and discuss the anatomy, clinical significance, and therapeutic options for an aneurysm at this site. We also retrospectively analyzed the record of a patient with a ruptured aneurysm of the intracranial segment of the OAT and conducted a comprehensive and systematic review of the PubMed and Scopus databases for literature on this pathology. Only one case report of SAH from an aneurysm of the intracranial segment of the OAT was published in the literature. Only in our case was the intracranial OAT segment aneurysm discovered in the acute phase of SAH. Conventional angiography with three-dimensional acquisition may help detect aneurysms at this level. Detailed knowledge of the anatomy of the OAT is of paramount importance for both surgical and endovascular approaches. Surgical treatment is complex because of difficulties in accessing the orbital region and the risk of optic nerve and vascular injuries. Endovascular treatment, when feasible, could be a good alternative to reduce the risk of loss of vision related to surgical manipulation.
Giant Epidermoid Cyst: A Rare Cause of Temporal Lobe Epilepsy
Authors: Trindade Vinicius , Gomes Marcos , Santo Marcelo , Teixeira Manoel , Paiva Wellingson 
Published: July 2017

Introduction Epidermoid tumors represent approximately 0.3 to 1.8% of all intracranial brain tumors. Only 1.5% of all intracranial epidermoid cysts (ECs) invade the brain and secondary epilepsy is extremely rare. Since August 2014, a 59-year-old male smoker had been presenting bad smell feelings, totaling four episodes with sudden onset and duration of 2 minutes. On September 2014, after a sense of smell episode, it evolved into loss of contact and automatic movements followed by generalized tonic–clonic movements. The brain magnetic resonance imaging revealed an extensive subtemporal lesion affecting anterior, middle, and posterior fossa with invasion of the choroidal fissure and projection to the temporal horn of the lateral ventricle. Pretemporal craniotomy with combined approaches, transsylvian and subtemporal, allowed for the excision of a white keratinized and softened lesion suggestive of EC.
Discussion The optimal surgical strategy in individuals with ECs and seizures is not established. The evaluation of the cause and risk–benefit must be held to choose the appropriate surgical strategy: lesionectomy, lobectomy, or amygdalohippocampectomy. In this case, a lesionectomy was performed due to an absence of evidence of involvement of hippocampus and amygdala.
Conclusion Epilepsy secondary to ECs is a rare association. Lesionectomy can be an option with good results without increasing the morbidity.
Remifentanil up2date – Teil 1
Authors: Bushuven Stefan , Kreuer Sascha , Kranke Peter 
Published: July 2017

ZusammenfassungRemifentanil ist ein kurzwirksames, potentes Opioid mit guter Steuerbarkeit – und vor allem in der ambulanten Anästhesiologie nahezu unverzichtbar. Umso härter trifft uns die seit 2016 eingeschränkte Verfügbarkeit und Kontingentierung. Dieser Beitrag liefert einen Überblick über die Substanz, ihre Geschichte und pharmakologischen Eigenschaften.