bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of cholesteatoma among patients with allergic rhinitis: A nationwide investigation
Authors: Kuo Chin‐Lung , Shiao An‐Suey , Wen Hsyien‐Chia , Chang Wei‐Pin 
Published: August 2017

ObjectivesNo large population‐based studies have reported on the risk of cholesteatoma developing after allergic rhinitis (AR). This study used a nationwide population‐based claims database to investigate the hypothesis that AR may increase the risk of cholesteatoma.Study DesignRetrospective cohort study.MethodsData from Taiwan's Longitudinal Health Insurance Database were analyzed to compile the following: 1) 15,953 patients newly diagnosed with AR between 1997 and 2000, and 2) a comparison cohort of 63,812 matched non‐AR enrollees (with a ratio of 1 to 4). Each patient was followed for 10 years to identify cases in which cholesteatoma subsequently developed. The Kaplan‐Meier method was used to determine the cholesteatoma‐free survival rate, and the log‐rank test was used to compare survival curves. Cox proportional hazard regressions were performed to compute adjusted hazard ratios (HRs).ResultsAmong the 79,765 patients enrolled in this study, 45 (159,364 person‐years) from the AR cohort and 88 (638,130 person‐years) from the comparison cohort were diagnosed with cholesteatoma during the follow‐up period (incidence rates 0.28 and 0.14 of 1,000 person‐years, respectively). Patients with AR were more likely to develop cholesteatoma compared to those without AR (adjusted HR 1.57, 95% confidence interval = 1.05–2.34, P < 0.05). Patients with AR presented a significantly lower 10‐year cholesteatoma‐free survival rate than did those in the comparison group (log‐rank, P < 0.001).ConclusionThis is the first study to demonstrate a link between AR and the development of cholesteatoma. We suggest that clinicians keep this association in mind and carefully investigate the possibility of development of cholesteatoma among patients with AR.Level of Evidence3b. Laryngoscope, 128:547–553, 2018
Sleep apnea and risk of vertigo: A nationwide population‐based cohort study
Authors: Tsai Ming‐Shao , Lee Li‐Ang , Tsai Yao‐Te , Yang Yao‐Hsu , Liu Chia‐Yen , Lin Meng‐Hung , Hsu Cheng‐Ming , Chen Chin‐Kuo , Li Hsueh‐Yu 
Published: August 2017

ObjectiveTo investigate the risk of vertigo in patients with sleep apnea.Study DesignRetrospective cohort study.MethodsThis study used data from the National Health Insurance Research Database of Taiwan, a population‐based database. A total of 5,025 patients who were newly diagnosed with sleep apnea between January 1, 1997, and December 31, 2012, were identified from the Longitudinal Health Insurance Database 2000, a nationally representative database of 1 million randomly selected patients. Moreover, 20,100 patients without sleep apnea were matched at a 1:4 ratio by age, sex, socioeconomic status, and urbanization level. Patients were followed up until death or the end of the study period (December 31, 2013). The primary outcome was the occurrence of vertigo.ResultsPatients with sleep apnea had a significantly higher cumulative incidence of vertigo than those without sleep apnea (P < 0.001). The adjusted Cox proportional hazard model showed that sleep apnea was significantly associated with a higher incidence of vertigo (hazard ratio, 1.71; 95% confidence interval [CI], 1.48–1.97; P < 0.001). Sensitivity and subgroup analyses were performed to adjust for confounders, including head trauma, diabetes mellitus, hypertension, stroke, and obesity. Sleep apnea was demonstrated to be an independent risk factor for vertigo.ConclusionThis is the first nationwide population‐based cohort study to investigate the association between sleep apnea and vertigo. The findings strongly support that sleep apnea is an independent risk factor for vertigo. Based on the study results, physicians should be aware of potential vertigo occurrence following sleep apnea.Level of Evidence4. Laryngoscope, 128:763–768, 2017
Quality of life outcomes of transoral robotic surgery with or without adjuvant therapy for oropharyngeal cancer
Authors: Sethia Rishabh , Yumusakhuylu Ali C. , Ozbay Isa , Diavolitsis Virginia , Brown Nicole V. , Zhao Songzhu , Wei Lai , Old Matthew , Agrawal Amit , Teknos Theodoros N. , Ozer Enver 
Published: August 2017

Objectives/HypothesisTo compare quality of life (QOL) of patients who underwent transoral robotic surgery (TORS) alone, with adjuvant radiation therapy (RT), or adjuvant chemoradiation therapy (CRT) in the treatment of oropharyngeal squamous cell cancer (OPSCCA).Study DesignProspective cohort study.MethodsMedical records were reviewed for 111 patients treated for OPSCCA from 2008 to 2015. Patients were administered the Head and Neck Cancer Inventory (HNCI) to evaluate QOL preoperatively, and at 3 weeks, 3 months, 6 months, and 1 year postsurgery. QOL data were compared between 13 patients treated with TORS alone, 31 with adjuvant RT, and 67 with adjuvant CRT by a linear mixed effects model.ResultsMean follow‐up was 35 months. The HNCI response rates at 3 weeks and 3, 6, and 12 months were 80%, 60%, 55%, and 46%, respectively. TORS alone reported significantly higher eating scores than adjuvant RT or CRT at 3 and 6 months, and higher speech scores compared to adjuvant CRT at 3 months and adjuvant RT at 6 months. TORS alone and adjuvant RT reported less social disruption compared to adjuvant CRT at 3 months. Adjuvant CRT had consistently lower overall QOL scores until 6 months. No TORS‐alone patient required percutaneous endoscopic gastrostomy, and no study patient required tracheostomy during treatment.ConclusionsTORS alone maintained higher QOL than adjuvant RT or CRT in eating, social function, speech, and overall QOL postsurgery. QOL and functional metrics were better for 6 months in TORS‐alone patients, and at 12 months, the differences were not significant.Level of Evidence4. Laryngoscope, 128:403–411, 2018
Repairing the vibratory vocal fold
Authors: Long Jennifer L. 
Published: August 2017

ObjectiveA vibratory vocal fold replacement would introduce a new treatment paradigm for structural vocal fold diseases such as scarring and lamina propria loss. This work implants a tissue‐engineered replacement for vocal fold lamina propria and epithelium in rabbits and compares histology and function to injured controls and orthotopic transplants. Hypotheses were that the cell‐based implant would engraft and control the wound response, reducing fibrosis and restoring vibration.Study DesignTranslational research.MethodsRabbit adipose‐derived mesenchymal stem cells (ASC) were embedded within a three‐dimensional fibrin gel, forming the cell‐based outer vocal fold replacement (COVR). Sixteen rabbits underwent unilateral resection of vocal fold epithelium and lamina propria, as well as reconstruction with one of three treatments: fibrin glue alone with healing by secondary intention, replantation of autologous resected vocal fold cover, or COVR implantation. After 4 weeks, larynges were examined histologically and with phonation.ResultsFifteen rabbits survived. All tissues incorporated well after implantation. After 1 month, both graft types improved histology and vibration relative to injured controls. Extracellular matrix (ECM) of the replanted mucosa was disrupted, and ECM of the COVR implants remained immature. Immune reaction was evident when male cells were implanted into female rabbits. Best histologic and short‐term vibratory outcomes were achieved with COVR implants containing male cells implanted into male rabbits.ConclusionVocal fold cover replacement with a stem cell‐based tissue‐engineered construct is feasible and beneficial in acute rabbit implantation. Wound‐modifying behavior of the COVR implant is judged to be an important factor in preventing fibrosis.Level of EvidenceNA. Laryngoscope, 128:153–159, 2018
Grazing Intensity Affects Communities of Culturable Root‐Associated Fungi in a Semiarid Grassland of Northwest China
Authors: Chen Tao , Zhang Yawen , Christensen Michael , Li Chenhui , Hou Fujiang , Nan Zhibiao 
Published: August 2017

AbstractIntensive grazing by large herbivores is known to result in the degeneration of grassland worldwide. However, little is known about how grazing affects the fungi living in roots, especially those with septate hyphae. We investigated grazing intensity effects on culturable root‐associated fungi (c‐RAF) of three dominant plant species; Artemisia capillaris, Lespedeza davurica, and Stipa bungeana, in a semiarid grassland of northwest China. Plant roots were sampled from four grazing intensities at four sampling dates. The total colonization rate of c‐RAF was not affected by grazing intensity, but the diversity of c‐RAF displayed a hump‐shaped trend with grazing intensities. Few c‐RAF were present in all plant species, with most of them being confined to only one or two plant species. The 16 most commonly isolated species were selected to investigate their effects on plant growth and health. Three Fusarium species were most pathogenic c‐RAF. Three dark‐sterile species did not affect growth parameters, regardless of host plants. With A. capillaris, the occurrence of Fusarium spp. was highest in the control plots, while with S. bungeana, the occurrence tended to increase as the grazing intensity increased. Two dark‐sterile species, including Darksidea alpha, in L. davurica roots increased with grazing intensities; in contrast, D. alpha decreased for S. bungeana with grazing intensities. Our results strongly suggest that in grasslands, grazing intensity can lead to changes in the colonization of specific root fungal taxa, and these fungal changes would potentially feed back to plant performance depending on the abundance of host plants. Copyright © 2017 John Wiley & Sons, Ltd.
Scraping by: Income and Program Participation After the Loss of Extended Unemployment Benefits
Authors: Rothstein Jesse , Valletta Robert G. 
Published: August 2017

AbstractMany Unemployment Insurance (UI) recipients do not find new jobs before exhausting their benefits, even when benefits are extended during recessions. Using Survey of Income and Program Participation (SIPP) panel data covering the 2001 and 2007 to 2009 recessions and their aftermaths, we identify individuals whose jobless spells outlasted their UI benefits (exhaustees) and examine household income, program participation, and health‐related outcomes during the six months following UI exhaustion. For the average exhaustee, the loss of UI benefits is only slightly offset by increased participation in other safety net programs (e.g., food stamps), and family poverty rates rise substantially. Self‐reported disability also rises following UI exhaustion. These patterns do not vary dramatically across household demographic groups, broad income level prior to job loss, or the two business cycles. The results highlight the unique, important role of UI in the U.S. social safety net.
National trends in use and costs of oral anticancer drugs in France: An 8‐year population‐based study
Authors: Bosco‐Lévy Pauline , de Boissieu Paul , Gouverneur Amandine , Noize Pernelle , Molimard Mathieu , Fourrier‐Réglat Annie , Bezin Julien 
Published: August 2017

AbstractPurposeDuring the last decade, many oral anticancer drugs (OAcDs) have been marketed, providing interesting but potentially costly pharmaceutical alternatives to intravenous treatments. This study aims to provide updated information on their use and costs.MethodsA cross‐sectional yearly repeated study was conducted from 2006 to 2014 using the representative sample of the French national health care insurance system claims database (EGB). OAcD use was described for each year, among prevalent (ie, patients with at least 1 OAcD reimbursement) and incident users (ie, patients with no OAcD reimbursement within the prior year) and according to their pharmacological classes (Hormone Therapy [HT], Cytotoxic Therapy [CT], Targeted Therapy [TT], and others). Demographic characteristics were described for both users; comorbidities and direct medical costs were described for incident users only.ResultsThe yearly prevalence and incidence of OAcD use, mainly represented by HT, remained stable from 2006 to 2014 (1.2%; 0.4%). Compared with users of other OAcD classes, the proportion of TT users substantially increased over the 8‐year study period (+9.3%), and TT incident users had more severe comorbidities at treatment initiation. The health expenditures were the most important in TT users with median monthly medical direct costs varying from 2995€ to 4968€ per patient between 2006 and 2014.ConclusionWith the development of new OAcDs, the TTs use reaches a wider population of patients but is responsible for increasing health expenditures.
Robust stability and stabilization for descriptor systems with uncertainties in all matrices
Authors: Cheng Shengnan , Zhang Qingling 
Published: August 2017

SummaryThis paper is concerned with the robust stability and stabilization via state feedback for a class of continuous linear time‐invariant descriptor systems with norm‐bounded perturbations in derivative matrix E and other systems matrices A and B. Due to the fact that matrix E being rank invariant is an efficient necessary condition to the solvability of stabilization via state feedback, perturbations in matrix E can be described in a new form that is different from the general form studied in previous works. Problems under consideration fall into 2 cases, ie, one is expressed by a constant matrix left multiplying an invertible uncertain matrix, and the other is produced by a dual form of the first case. Then, we transfer the problem of robust stability into the question of a feasible solution for linear matrix inequality and necessary and sufficient conditions for stability are derived for the 2 cases. In terms of the stabilization problem, by using a new state augmentation technique, we transfer the descriptor system with uncertainties in the derivative matrix into an augmented descriptor system that the derivative matrix has no uncertainties, and we find that there are no properties changed during this augmentation process. Next, basing on the theory of stability, we receive sufficient conditions to the original stabilization problem for the 2 cases. Finally, 2 numerical examples are given to illustrate the effectiveness and merits of the main results.
Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings
Authors: Wang Cheng , Liu Jiao , Liu Huanhuan , Liang Shaoxiong , Wen Jianping 
Published: August 2017

Abstract
Tacrolimus is widely used as an immunosuppressant in the treatment of various autoimmune diseases. However, the low fermentation yield of tacrolimus has thus far restricted its industrial applications. To solve this problem, the time-series response mechanisms of the intracellular metabolism that were highly correlated with tacrolimus biosynthesis were investigated using different exogenous feeding strategies in S. tsukubaensis. The metabolomic datasets, which contained 93 metabolites, were subjected to weighted correlation network analysis (WGCNA), and eight distinct metabolic modules and seven hub metabolites were identified to be specifically associated with tacrolimus biosynthesis. The analysis of metabolites within each metabolic module suggested that the pentose phosphate pathway (PPP), shikimate and aspartate pathway might be the main limiting factors in the rapid synthesis phase of tacrolimus accumulation. Subsequently, all possible key-limiting steps in the above metabolic pathways were further screened using a genome-scale metabolic network model (GSMM) of S. tsukubaensis. Based on the prediction results, two newly identified targets (aroC and dapA) were overexpressed experimentally, and both of the engineered strains showed higher tacrolimus production. Moreover, the best strain, HT-aroC/dapA, that was engineered to simultaneously enhanced chorismate and lysine biosynthesis was able to produce 128.19 mg/L tacrolimus, 1.64-fold higher than control (78.26 mg/L). These findings represent a valuable addition to our understanding of tacrolimus accumulation in S. tsukubaensis, and pave the way to further production improvements.
A Novel Alkyl Sulphobetaine Gemini Surfactant Based on S‐triazine: Synthesis and Properties
Authors: Niu Ruixia , Wang Chao , Sun Zhigang , Long Biao , Song Hua , Ren Weidong , Wang Daqiang , He Junyao 
Published: August 2017

AbstractA series of alkyl sulphobetaine Gemini surfactants Cn‐GSBS (n = 8, 10, 12, 14, 16) was synthesized, using aliphatic amine, cyanuric chloride, ethylenediamine, N,N′‐dimethyl‐1,3‐propyldiamine and sodium 2‐chloroethane sulfonate as main raw materials. The chemical structures were confirmed by FT‐IR, 1H NMR and elemental analysis. The Krafft points differ markedly with different carbon chain length, for C8‐GSBS, C10‐GSBS and C12‐GSBS are considered to be below 0 °C and C14‐GSBS, C16‐GSBS are higher than 0 °C but lower than room temperature. Surface‐active properties were studied by surface tension and electrical conductivity. Critical micelle concentrations were much lower than dodecyl sulphobetaine (BS‐12) and decreased with increasing length of the carbon chain from 8 to 16, and can reach a minimum as low as 5 × 10−5 mol L−1 for C16‐GSBS. Effects of carbon chain length and concentration of Cn‐GSBS on crude oil emulsion stability were also investigated and discussed.
Naturalistic follow-up of subjects affected with anorexia nervosa 8 years after multimodal treatment: Personality and psychopathology changes and predictors of outcome
Authors: Amianto F. , Spalatro A. , Ottone L. , Abbate Daga G. , Fassino S. 
Published: August 2017

AbstractBackground:Eating disorders (EDs) are serious mental illnesses of growing clinical and social impact. Despite their severity, there is still no satisfactory evidence-based treatment. Follow-up investigations are the most reliable studies to enlighten long-term outcome predictors and modifiers.Methods:In total, 59 subjects affected with anorexia nervosa were assessed 8 years after their admission into an outpatient multimodal treatment program for eating disorders. The follow-up changes in diagnostic criteria were compared with Chi-square test. Improved and not-improved subjects were compared. Clinical, personality and psychopathology features between T0 and T1 were compared witht-test for repeated measures. Correlation between T0 features and changes at T1 in personality and psychopathology features were assessed.Results:The rate of complete remission was 42%, an overall rate of 67.8% improved, a rate of 18.6% worsened. Concerning personality, a significant decrease of harm avoidance and increase in self-directedness were evidenced. Interoceptive awareness, drive for thinness, bulimia were significantly reduced at follow-up. Many T0 personality facets were related to personality and psychopathology improvement at follow-up.Conclusion:Multimodal treatment encompassing psychiatric, nutritional and psychological approaches is at the moment the most reliable approach for the treatment of moderate to severe anorexia nervosa with a discrete rate of improvement. Some personality and psychopathology characteristics may represent specific factors which favor resistance and impair improvement. Future approaches should consider the personalization of therapeutic approach according to these features.
Dynamic and static mechanical pain sensitivity is associated in women with migraine
Authors: Palacios-Ceña M. , Ruíz M. , Barón J. , Guerrero-Peral A.L. , Fernández-de-las-Peñas C. , Arendt-Nielsen L. 
Published: August 2017

Abstract

Aims
To explore the association between static (hyperalgesia) and dynamic (allodynia) pressure algometry for assessing muscle pain hypersensitivity in women with migraine.

Methods
One hundred and twenty women with migraine (42% chronic, 58% episodic) participated. Dynamic muscle allodynia was assessed with a dynamic pressure algometry set (Aalborg University, Denmark©) consisting of 11 rollers with fixed pressure levels from 500 g to 5300 g. Each roller was moved at a speed of 0.5 cm/s over a 60 mm horizontal line covering the temporalis muscle. Dynamic pain threshold (DPT-pressure level of the first painful roller) was calculated on each side of the head. Migraine pain features were collected on a headache-diary. As golden standard, static pressure pain thresholds (PPTs) were assessed over the temporalis muscle, C5/C6 joint, second metacarpal and tibialis anterior to assess widespread pressure hyperalgesia.

Results
Side-to-side consistency between DPT (r = 0.769, P < 0.001) was found. DPT was moderately associated with widespread PPTs (0.364 > r > 0.769, all P < 0.001). No significant association with migraine pain features (frequency, intensity or duration of migraine attack) were observed (all, P > 0.129). Associations were similar in women with episodic or chronic migraine.

Conclusions
Dynamic pressure algometry was valid for assessing dynamic mechanical muscle allodynia in migraine. DPT was associated with widespread static muscle hyperalgesia independently of migraine frequency supporting that dynamic muscle allodynia in the trigeminal area is consistent with generalized pressure pain hyperalgesia. Assessing dynamic deep somatic tissue sensitivity may provide a new tool for assessing treatment effects.
Buprenorphine alleviation of pain does not compromise the rat monoarthritic pain model
Authors: Berke M.S. , Abelson Klas S.P. 
Published: August 2017

Abstract

Aims
This study investigated the effects of buprenorphine treatment on pain and welfare parameters and model specific parameters in a rat model of monoarthritis to eliminate unnecessary pain from this model.

Methods
32 male Sprague Dawley rats were divided into four groups: (1) A negative control without arthritis receiving no analgesia. (2) A positive monoarthritic control group receiving no analgesia, but subcutaneous saline injections twice a day. (3) A positive control with monoarthritis receiving subcutaneous carprofen once a day and saline once a day. (4) A group with monoarthritis receiving subcutaneous buprenorphine twice a day. Monoarthritis was induced with an injection of 0.02 ml Complete Freund’s Adjuvant intra-articularly in the left tibiotarsal joint. Treatment with analgesia was initiated at day 15 and the rats were euthanized at day 23.

Results
The induced monoarthritis elicited a pronounced acute inflammation. Several parameters such as bodyweight, mobility, stance, joint-stiffness and lameness scores were affected. A marked mechanical hyperalgesia in the tarsal area was observed by Electronic Von Frey testing, but no severe compromise of the animal welfare was seen at any time. Signs of chronic development began to appear from day 10 after the monoarthritic induction. No significant change in serum cytokines and faecal corticosterone measurements was found after administration of buprenorphine. A minor decrease in body weight was seen, and a higher pain tolerance to mechanical stimuli was observed, indicating pain alleviation. The histological examination confirmed monoarthritic development in all monoarthritic rats and revealed periarticular lesions suggesting diffusion of adjuvant from intra-articular injection site to the periphery.

Conclusions
The study demonstrated that buprenorphine has an analgesic effect in the adjuvant induced monoarthritic rat model, without obvious interference with the development of arthritis.