bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Electronic Health Record Data to Measure Care Quality for Individuals with Multiple Chronic Medical Conditions
Authors: Bayliss Elizabeth A. , McQuillan Deanna B. , Ellis Jennifer L. , Maciejewski Matthew L. , Zeng Chan , Barton Mary B. , Boyd Cynthia M. , Fortin Martin , Ling Shari M. , Tai‐Seale Ming , Ralston James D. , Ritchie Christine S. , Zulman Donna M. 
Published: July 2016

ObjectivesTo inform the development of a data‐driven measure of quality care for individuals with multiple chronic conditions (MCCs) derived from an electronic health record (EHR).DesignQualitative study using focus groups, interactive webinars, and a modified Delphi process.SettingResearch department within an integrated delivery system.ParticipantsThe webinars and Delphi process included 17 experts in clinical geriatrics and primary care, health policy, quality assessment, health technology, and health system operations. The focus group included 10 individuals aged 70–87 with three to six chronic conditions selected from a random sample of individuals aged 65 and older with three or more chronic medical conditions.MeasurementsThrough webinars and the focus group, input was solicited on constructs representing high‐quality care for individuals with MCCs. A working list was created of potential measures representing these constructs. Using a modified Delphi process, experts rated the importance of each possible measure and the feasibility of implementing each measure using EHR data.ResultsHigh‐priority constructs reflected processes rather than outcomes of care. High‐priority constructs that were potentially feasible to measure included assessing physical function, depression screening, medication reconciliation, annual influenza vaccination, outreach after hospital admission, and documented advance directives. High‐priority constructs that were less feasible to measure included goal setting and shared decision‐making, identifying drug–drug interactions, assessing social support, timely communication with patients, and other aspects of good customer service. Lower‐priority domains included pain assessment, continuity of care, and overuse of screening or laboratory testing.ConclusionHigh‐quality MCC care should be measured using meaningful process measures rather than outcomes. Although some care processes are currently extractable from electronic data, capturing others will require adapting and applying technology to encourage holistic, person‐centered care.
Impact of bleaching agents on water sorption and solubility of resin luting cements
Authors: Torabi Ardakani Mahshid , Atashkar Berivan , Bagheri Rafat , Burrow Michael F. 
Published: July 2016

AbstractAimThe aim of the present study was to evaluate the effect of distilled water and home and office bleaching agents on the sorption and solubility of resin luting cements.MethodsA total of 18 disc‐shaped specimens were prepared from each of four resin cements: G‐CEM LinkAce, Panavia F, Rely X Unicem, and seT. Specimens were cured according to the manufacturers’ instructions and randomly divided into three groups of six, where they were treated with either an office or home bleaching agent or immersed in distilled water (control). Water sorption and solubility were measured by weighing the specimens before and after immersion and desiccation. Data were analyzed using Pearson correlation coefficient, two‐way analysis of variance (ANOVA) and Tukey's test.ResultsThere was a significant, positive correlation between sorption and solubility. Two‐way anova showed significant differences among all resin cements tested for either sorption or solubility. Water sorption and solubility of all cements were affected significantly by office bleaching, and even more by home bleaching agents.ConclusionsSorption and solubility behavior of the studied cements were highly correlated and significantly affected by applying either office or home bleaching agents; seT showed the highest sorption and solubility, whereas Rely X Unicem revealed the lowest.
Expression of podoplanin and TGF‐beta in glandular odontogenic cyst and its comparison with developmental and inflammatory odontogenic cystic lesions
Authors: Alaeddini Mojgan , Eshghyar Nosratollah , Etemad‐Moghadam Shahroo 
Published: July 2016

BackgroundThe number of studies investigating the immunohistochemical characteristics of glandular odontogenic cysts (GOCs) is limited, due to its rarity. TGF‐beta has been suggested to induce podoplanin expression in some lesions. We aimed to evaluate and compare podoplanin and TGF‐beta expression in GOC and other odontogenic cystic lesions.MethodsA total of 43 samples including five GOCs, 10 dentigerous cysts (DCs), eight unicystic ameloblastoma (UAs), and 20 radicular cysts (RCs) were selected and subjected to immunohistochemical staining using monoclonal antibodies against podoplanin and TGF‐beta. Kruskal–Wallis test and Mann–Whitney U‐test were used for statistical analysis along with Bonferroni for adjusting P‐values (P < 0.05).ResultsPodoplanin immunoreactivity was observed in 80%, 70%, and 100% of DCs, RCs, and UAs, respectively, while none of the GOCs were positive for this marker (P = 0.004). Significant differences were only found in the GOC specimens. TGF‐beta positivity occurred in the capsule and epithelium of all GOCs and DCs, while RCs and UAs demonstrated different expression percentages in the capsular and epithelial tissues. Epithelial TGF‐beta showed significant differences among the studied lesions (P = 0.007) with the main difference found between DCs with RCs and DCs with UAs.ConclusionsLack of podoplanin expression might be involved in the characteristic histologic and behavioral features of GOC, which seems to be unrelated to TGF‐beta expression.
Crime, Search, and Ex‐offenders’ Accessibility to Labor Markets
Authors: Otsu Yuki 
Published: July 2016

AbstractRehabilitation for ex‐offenders has positive (e.g. more production) and negative (e.g. more crime) effects on society. We investigate the effect of rehabilitation on criminal behavior and the labor market using a search model. In the case where ex‐offenders cannot join the labor market, promoting rehabilitation for them may reduce crime. In such a case, the equilibrium allocation may be inefficient. Moreover, under the Hosios condition, equilibrium labor market tightness is lower than the efficient outcome because of crime, as the crime option raises the value of unemployed workers. Because this option works as a negative externality on matched firms, equilibrium tightness is lower than the optimal level.
A spontaneous mutation in MutL‐Homolog 3 (HvMLH3) affects synapsis and crossover resolution in the barley desynaptic mutant des10
Authors: Colas Isabelle , Macaulay Malcolm , Higgins James D. , Phillips Dylan , Barakate Abdellah , Posch Markus , Armstrong Susan J. , Franklin F. Chris H. , Halpin Claire , Waugh Robbie , Ramsay Luke 
Published: July 2016

Summary

Although meiosis is evolutionarily conserved, many of the underlying mechanisms show species‐specific differences. These are poorly understood in large genome plant species such as barley (Hordeum vulgare) where meiotic recombination is very heavily skewed to the ends of chromosomes.

The characterization of mutant lines can help elucidate how recombination is controlled. We used a combination of genetic segregation analysis, cytogenetics, immunocytology and 3D imaging to genetically map and characterize the barley meiotic mutant DESYNAPTIC 10 (des10).

We identified a spontaneous exonic deletion in the orthologue of MutL‐Homolog 3 (HvMlh3) as the causal lesion. Compared with wild‐type, des10 mutants exhibit reduced recombination and fewer chiasmata, resulting in the loss of obligate crossovers and leading to chromosome mis‐segregation. Using 3D structured illumination microscopy (3D‐SIM), we observed that normal synapsis progression was also disrupted in des10, a phenotype that was not evident with standard confocal microscopy and that has not been reported with Mlh3 knockout mutants in Arabidopsis.

Our data provide new insights on the interplay between synapsis and recombination in barley and highlight the need for detailed studies of meiosis in nonmodel species. This study also confirms the importance of early stages of prophase I for the control of recombination in large genome cereals.
Application of extended H plate to open reduction internal fixation of the mandibular condyle
Authors: Aaronson N.L. , Sasaki C.T. , Lowlicht R.A. 
Published: July 2016

AbstractFractures of the condyle are among the most common of mandibular fractures. They have traditionally been managed by closed reduction except in cases of severe displacement. Recent data suggest that a broader class of patients with condyle fractures may benefit from open reduction internal fixation (ORIF). We present a case of a condylar neck fracture managed by ORIF via the retromandibular approach using the extended H plate from the Synthes LCP handset. This patient subsequently had restoration of his pre‐operative occlusion with return to normal masticatory function. Use of the extended H plate when performing ORIF provides three‐dimensional stabilisation of the fracture segments avoiding the need for post‐operative fixation and allowing more rapid return to function.
Vitamin D insufficiency in a boy with obsessive–compulsive disorder
Authors: Celik Gonca , Tas Didem Arslan , Varmıs Dilek Altun , Tahiroglu Aysegul , Avci Ayse 
Published: July 2016

AbstractVitamin D deficiency not only causes low bone mass but also may lead to neuropsychiatric disorders. In the present case, vitamin D supplementation reduced obsessive–compulsive disorder (OCD) symptoms associated with streptococcal infection in a 7‐year‐old boy. Sudden onset of symptoms, including excessive hand washing and fear of touching anything, had occurred 1 month before presentation. Although there are few studies on a possible causal relationship between vitamin D and neuropsychiatric disorders, the present report; together with previous data, suggest an etiological role of vitamin D‐related immune processes.
Usefulness of CBCL/6‐18 to evaluate emotional and behavioral problems in Indonesian autism spectrum disorder children
Authors: Hartini Sri , Sunartini  , Herini Elisabeth S , Takada Satoshi 
Published: July 2016

AbstractBackgroundThe Child Behavior Checklist (CBCL) has been widely utilized to estimate emotional and behavioral problems in children in the USA and Europe. Although the Indonesian version of the CBCL/6‐18 was proven to have good validity and internal consistency in children with typical development (TD) in Indonesia, it has not been utilized for children with autism spectrum disorder (ASD). The purpose of this study was therefore to investigate the usefulness of CBCL/6‐18 for detecting emotional and behavioral problems in Indonesian ASD children.MethodsOne hundred and eight mothers of children with ASD and with TD were enrolled in this study. The diagnosis of ASD in Indonesia was made by expert child neurologists based on DSM‐IV‐TR. Mothers of children aged 6–18 years completed the Indonesian version of the CBCL.ResultsThe scores of total problems, internalizing, and externalizing were significantly higher in the ASD group than the TD group. Children with ASD scored significantly higher in seven of the eight CBCL subscales (except somatic complaints) compared with TD children.ConclusionsThe CBCL/6‐18 Indonesian version could be considered as a useful tool for detecting emotional and behavioral problems in children with ASD in Indonesia in Muslim populations.
A paediatric case of successful non‐myeloablative bone marrow transplantation after azacitidine therapy for non‐Down syndrome acute megakaryoblastic leukaemia with monosomy 7
Authors: Koga Yuhki , Oba Utako , Kato Wakako , Ono Hiroaki , Nakashima Kentaro , Takada Hidetoshi 
Published: July 2016

AbstractWe report a patient with non‐Down syndrome AML, also known as AMKL, with monosomy 7, who was also obese and had a hearing impairment and mental retardation. Non‐myeloablative bone marrow transplantation was performed successfully after the patient received less aggressive azacitidine treatment, without the usual intensive induction chemotherapy regimen for AML.
Can I trust in what I see? EEG evidence for a cognitive evaluation of perceptual constructs
Authors: Kornmeier Jürgen , Wörner Rike , Bach Michael 
Published: July 2016

AbstractEnvironmental information available to our senses is incomplete and to varying degrees ambiguous. It has to be disambiguated in order to construct stable and reliable percepts. Ambiguous figures are artificial examples where perception is maximally unstable and alternates between possible interpretations. Tiny low‐level changes can disambiguate an ambiguous figure and thus stabilize percepts. The present study compares ERPs evoked by ambiguous stimuli and disambiguated stimulus variants across three visual categories: geometry (Necker cube), motion (stroboscopic alternative motion stimulus, SAM) and semantics (Boring's old/young woman). We found that (a) disambiguated stimulus variants cause stable percepts and evoke two huge positive ERP excursions (Cohen's effect sizes 1–2), (b) the amplitudes of these ERP effects are inversely related to the degree of stimulus ambiguity, and (c) this pattern of results is consistent across all three tested visual categories. This generality across visual categories points to mechanisms at a very abstract (cognitive) level of processing. We discuss our results in the context of a high‐level Bayesian inference unit that evaluates the reliability of perceptual processing results, given a priori incomplete, ambiguous sensory information. The ERP components may reflect the outcome of this reliability estimation.
Network Structure and Perceived Legitimacy in Collaborative Wildlife Management
Authors: Sandström Annica , Lundmark Carina 
Published: July 2016

AbstractThe widespread supposition that collaborative management designs enhance legitimacy must be examined empirically, and the rich diversity of different collaborative arrangements should be better acknowledged in this endeavor. This study adopts a social network perspective and examines three state‐initiated and interest‐based collaborative management arenas in Swedish wildlife management: wildlife conservation committees (WCCs). Is there a link between social network structures in collaborative management arenas and the perceived legitimacy of output by policy stakeholders? This puzzle is addressed through social network analysis combined with survey data and interviews. The empirical results confirm the notion that collaborative arenas consisting of high network closure with many bridging ties across organizational boundaries enjoy a higher level of support among stakeholders directly involved in management, as members of the committees, than networks with a more sparse structure do. This type of well‐integrated network structure seemingly increases stakeholders’ understanding of other actors’ perspectives through deliberation. Contrary to what was expected, though, the empirical analysis did not verify the effect of linking, or outreaching ties between the committee members and the organizations that they represent, on the organizations’ support of WCC decisions. Given the rapid rise of collaborative designs in public administrations, the topic elaborated in this paper is urgent and further research is encouraged.
Do We Understand What the Public Hears? Stakeholders’ Preferred Communication Choices for Discussing River Issues with the Public
Authors: Lybecker Donna L. , McBeth Mark K. , Stoutenborough James W. 
Published: July 2016

AbstractCommunication between stakeholders and the larger public is an increasingly important issue in today's policy world. This communication often takes the form of policy narratives; however, few studies have empirically examined what type of communication style stakeholders prefer for communication with the public. This study uses a survey of 87 river stakeholders to determine the preferred communication choices of stakeholders. The study finds that 39% of the stakeholders chose a duty‐based narrative, 28% choose a science statement, 23% choose an engaged citizen narrative, and 10% choose a do nothing statement. Some of these preferences were related to issues of trust, other policy preferences, and demographic background. Based on previous research, the findings demonstrate that stakeholders can make decisions about how to communicate with the public that are not necessarily reflective of the own values.
Trade and Industrial Policy as Levers for Sustainable Energy Technology Adoption? Experiences from Urban Latin America
Authors: Mallett Alexandra 
Published: July 2016

AbstractDebates abound regarding the link between trade and industrial policy and the adoption of sustainable energy technologies in developing countries. Some purport that open trade regimes support technology diffusion, while others indicate that more interventionist regimes are more conducive. This paper uses empirical evidence from Mexico City and São Paulo to argue that sustainable energy technology uptake can be more prevalent in settings with partially open trade policy regimes. These regimes have afforded countries more opportunities to develop local capabilities, which, in turn, has had knock‐on effects on sustainable energy technology uptake. Specifically, having more local technology sources (equipment, expertise) brought quicker access to these technologies, created more perceptions of technology “ownership,” fostered more effective mobilization, and helped create well‐established standards, which in turn contributed positively to sustainable energy technology uptake, while taxes and tariffs were less influential.
Lasiodiplodia species fungal osteomyelitis in a multiple myeloma patient
Authors: Mohan M. , Shalin S.C. , Kothari A. , Rico J.C.C. , Caradine K. , Burgess M. 
Published: July 2016

AbstractLasiodiplodia species are environmental fungi that have been reported as a cause of infection in both immunocompetent and immunocompromised patients. We present a case of fungal osteomyelitis caused by Lasiodiplodia species in a patient with multiple myeloma after autologous stem cell transplant. The patient was successfully treated with a combination of surgery and oral voriconzole. To the best of our knowledge, this is the first reported case of fungal osteomyelitis caused by Lasiodiplodia species.
A D+ blood donor with a novel RHD*D‐CE(5‐6)‐D gene variant exhibits the low‐frequency antigen RH23 (DW) characteristic of the partial DVa phenotype
Authors: Lopez Genghis H. , McGowan Eunike C. , McGrath Kelli A. , Abaca‐Cleopas Maria E. , Schoeman Elizna M. , Millard Glenda M. , O'Brien Helen , Liew Yew‐Wah , Flower Robert L. , Hyland Catherine A. 
Published: July 2016

BACKGROUNDBlood donors whose red blood cells (RBCs) exhibit a partial RhD phenotype, lacking some D epitopes, present as D+ in routine screening. Such phenotypes can exhibit low‐frequency antigens (LFAs) of clinical significance. The aim of this study was to describe the serologic and genetic profile for a blood donor with an apparent D+ phenotype carrying a variant RHD gene where D Exons 5 and 6 are replaced by RHCE Exon (5‐6).STUDY DESIGN AND METHODSAnti‐D monoclonal antibodies were used to characterize the presentation of RhD epitopes on the RBCs. RHD exon scanning and DNA sequencing of short‐ and long‐range polymerase chain reaction amplicons were used to determine the RHD structure and sequence. Extended phenotyping for LFAs RH23 (DW) and Rh32 was performed.RESULTSThe donor serology profile was consistent with partial RhD epitope presentation. The donor was hemizygous for an RHD variant allele described as RHD*D‐CE(5‐6)‐D hybrid. The RHCE gene insert is at least 3.868 kb with 5′ and 3′ breakpoints between IVS4 + 132–c.667 and IVS6 + 1960–IVS6 + 2099, respectively. The sequence for this hybrid was assigned GenBank Accession Number KT099190.2. The RBCs were RH23 (DW)+ and Rh32–.CONCLUSIONA novel RHD*D‐CE(5‐6)‐D hybrid allele encodes a partial RhD epitope and carries the LFA RH23 (DW). This and the epitope profile resemble the partial DVa phenotype. Given that RBCs from this individual lack some RhD epitopes, there is an alloimmunization risk if the donor is exposed to D+ RBCs. Conversely, transfusions of RH23 (DW)+ cells to RH23 (DW)– recipients also pose an alloimmunization risk.
Antibody complement–mediated hemolytic studies with kodecytes reveal that human complement utilized in the classical pathway is more stable than generally accepted
Authors: Perry Holly , Bovin Nicolai , Henry Stephen 
Published: July 2016

BACKGROUNDComplement has significant status in the field of transfusion medicine. The accepted stability profile of complement is based on historical studies of diluted human serum hemolyzing rabbit heterophile antibody–sensitized sheep red blood cells (RBCs). Contemporary tools are available to reevaluate these historical observations using human heterophile antibodies, undiluted serum, and antigen‐modified human RBCs.STUDY DESIGN AND METHODSHuman RBCs were made into “animal‐like” kodecytes with heterophile Galα3Galβ4GlcNAcβ function‐spacer‐lipid constructs. These α‐Gal‐kodecytes were prepared with an antigen dilution capable of consistently producing 50% antibody‐mediated hemolysis against human α1‐3galactose heterophile antibodies and undiluted standardized serum. Standardized human serum aliquots from a two‐donor pool stored at −85, −20, 4, 22, and 37°C for durations of up to 150 days were evaluated for loss of hemolytic activity. Where practical methodologic procedures were aligned with historical studies.RESULTSComparison of the historical assay with the α‐Gal‐kodecyte assay against complement activity standards showed concordance. However, in most scenarios complement was found to be more than twice as stable as generally accepted. At least 60% of complement hemolytic activity was observed in serum stored at 22°C for 1 week or 2 months at 4°C. No loss of hemolytic activity was observed after 5 months' storage at temperatures below −20°C.CONCLUSIONSAn alternative method using undiluted serum and modified human RBCs observed that classical‐pathway complement hemolytic activity in stored human serum is at least twice as stable as previously accepted.
The Omental Pedicle Flap in Dogs Revised and Refined: A Cadaver Study
Authors: Doom Marjan , Cornillie Pieter , Simoens Paul , Huyghe Stephanie , de Rooster Hilde 
Published: July 2016

ObjectiveTo expand current knowledge on the canine omental vasculature and refine the existing lengthening technique of the canine omentum.Study DesignEx vivo study.AnimalsCanine cadavers (n=20).MethodsIn 10 canine cadavers the omental arteries were mapped using intravascular latex injection and these results were used to create an omental pedicle flap based on the splenic artery in 10 additional cadavers. The operating range of the flap was recorded with particular attention to the main regions of interest for omental transposition in dogs (axillary and inguinal regions).ResultsThe superficial and deep omental leaves were each predominantly supplied by a left and a right marginal omental artery that anastomosed near the caudal omental border into a superficial and a deep omental arch, respectively. Anastomoses between arteries of the superficial and the deep omental leaves were weak and inconsistent, except for 1 anastomosis that was found in 8 of 10 dogs. By transposing the intact omentum, the right axilla could be reached in 3 dogs, both axillae in 1 dog, and both groins in all cadavers. In all cases, the omental pedicle reached to and beyond the axillary and inguinal regions. By unfolding the pedicle leaves, the width of the pedicle tip could be doubled.ConclusionWhen lengthening the omentum is necessary to reach extra‐abdominal structures, the omental pedicle flap based on the splenic artery appears to preserve the omental vascular supply. These observations warrant further clinical trials to evaluate this new omtental flap technique in vivo.