bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding Stakeholder Knowledge of the Home and Community Based Services (HCBS) Settings Rule
Authors: Friedman Carli 
Published: September 2017

Abstract
The Home and Community Based Services (HCBS) settings rule (CMS 2249-F/2296-F) strictly enforces meaningful community-based settings for those receiving Medicaid HCBS funding. Stakeholders have the opportunity to impact states' setting rule plans and hold states accountable to ensure rules are truly community based. Yet, the complex rule can be inaccessible for the very people it will impact most. This exploratory study evaluates the HCBS Advocates Creating Transformation (ACT) program's ability to educate 86 stakeholders about the rule. Our findings suggest that the HCBS ACT program pilot was a useful intervention that can be replicated for education and outreach programs. Doing so can actively engage people with disabilities, their families, and their support staff in the policy process.
Vertical Contract and Competition Intensity in Hotelling’s Model
Authors: Wang Xingtang , Li Jie , Wang Leonard F.S. 
Published: September 2017

AbstractThis paper explores the impact of intensity of rivalry in downstream market on the equilibrium locations of the downstream firms under a vertical market structure á la Hotelling. We find that: (i) the presence of upstream firms softens the spatial competition in downstream market; (ii) minimum differentiation cannot be achieved as the equilibrium outcome and the equilibrium product differentiation is insufficient relative to socially optimum; (iii) social welfare is higher with a higher weight attached to intensity of rivalry, which is different from the non-monotonic relationship under the horizontal market case; (iv) the equilibrium product differentiation is independent of bargaining power under the two-part tariff contracts, which is different from Brekke and Straume (2004) under linear pricing.
Effects of the genetic variants of organic cation transporters 1 and 3 on the pharmacokinetics of metformin in Jordanians
Authors: Hakooz Nancy , Jarrar Yazun Bashir , Zihlif Malik , Imraish Amer , Hamed Saja , Arafat Tawfiq 
Published: September 2017

AbstractBackground:Human response to the antidiabetic metformin is influenced by some factors, such as genetic variants in thePatients and methods:TheResults:Results showed that volunteers withConclusions:The
The association of NOV/CCN3 with obstructive sleep apnea (OSA): preliminary evidence of a novel biomarker in OSA
Authors: Weingarten Jeremy A. , Bellner Lars , Peterson Stephen J. , Zaw Moe , Chadha Puja , Singh Shailendra P. , Abraham Nader G. 
Published: September 2017

AbstractObstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk. Ten morbidly obese and 10 healthy lean subjects underwent overnight polysomnography (PSG) and clinical evaluation. Blood samples were analyzed for NOV levels, adiponectin and IL-6. OSA was found in nine obese subjects and three lean subjects. NOV levels were significantly higher in the OSA vs. no OSA group (2.1 ± 0.9 vs. 1.3 ± 0.8, p < 0.03). NOV levels were significantly higher in the obese vs. lean group (2.2 ± 0.3 vs. 1.4 ± 0.2-fold change, p < 0.03). Among lean subjects, NOV levels were significantly higher in the OSA vs. no OSA group (2.1 ± 0.9 vs. 1.0 ± 0.4, p < 0.05). NOV and AHI were positively correlated (ρ = 0.49, p = 0.033). IL-6 and adiponectin differences in obese vs. lean and OSA vs. no OSA were consistent with an inflammatory phenotype in obese subjects and OSA subjects. NOV is a novel biomarker of the presence and severity of OSA and a potential marker of future cardiovascular and metabolic disease in OSA patients.
Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure
Authors: Castro Érique , Silva Tiago E. Oliveira , Festuccia William T. 
Published: September 2017

AbstractBeige (or brite, “brown in white”) adipocytes are uncoupling protein 1 (UCP1)-positive cells residing in white adipose depots that, depending on the conditions, behave either as classic white adipocytes, storing energy as lipids, or as brown adipocytes, dissipating energy from oxidative metabolism as heat through non-shivering thermogenesis. Because of their thermogenic potential and, therefore, possible usage to treat metabolic diseases such as obesity and type 2 diabetes, beige cells have attracted the attention of many scientists worldwide aiming to develop strategies to safely recruit and activate their thermogenic activity. Indeed, in recent years, a large variety of conditions, molecules (including nutrients) and signaling pathways were reported to promote the recruitment of beige adipocytes. Despite of those advances, the true contribution of beige adipocyte thermogenesis to whole-body energy expenditure is still not completely defined. Herein, we discuss some important aspects that should be considered when studying beige adipocyte biology and the contribution to energy balance and whole-body metabolism.
Iron Supported on Ion Exchange Resin as Source of Iron for Fenton Reagent: A Heterogeneous or a Homogeneous Fenton Reagent Generation?
Authors: García-Rodríguez Orlando , Bañuelos Jennifer A. , Godínez Luis A. , Arredondo Valdez Hortencia C. , Zamudio Evelyn , Ramírez Victor , Rodríguez-Valadez Francisco J. 
Published: September 2017

Abstract
The aim of this work is to discuss the relative contribution of homogeneous and heterogeneous Fenton processes in the treatment of Orange II dye solutions at pH 3 and 7 using an ion exchange resin as iron support. While at pH 3, 99% of the colour was removed, under neutral conditions a decoloration of 56% was observed. Studying the release of iron from the resin, we found a concentration of 1.49 mg/L of ferric ion and 0.31 mg/L of ferrous ion at pH 3 and 1.08 mg/L and 0.11 mg/L at pH 7, revealing that as expected, dissolution of iron ions at pH 3 is larger. Using these concentrations in a homogeneous process, 45% of the colour can be removed at pH 3 and 10% at pH 7, so it was infered that there is an effect of the iron that is still supported on the resin. In this way, a mixed homogeneous/heterogeneous mechanism could be proposed. While the experimental data for the desorption of iron at pH 3 was well suited to a pseudo second order kinetic model, the desorption of iron at pH 7 was fit to pseudo-first order kinetics. Experimental results of dye decolorization were on the other hand, fitted to a pseudo first order kinetics.
Weak Bus-Oriented Installation of Phasor Measurement Unit for Power Network Observability
Authors: Babu Rohit , Bhattacharyya Biplab 
Published: September 2017

AbstractPhasor measurement unit (PMU) is a GPS-based monitoring equipment employed for the improvement of the stability and reliability of the electrical grid. In this work, an optimal PMU placement has been considered to utilize the least number of units in order to make the power network fully observable. Further, this article also suggests to not only determine the minimal number and optimal locations of PMUs but also installation of the maximum number of PMUs on the weakest bus in an electrical network. Thus, the weak bus based on line stability index utilizing load flow measurement is determined. Then a novel numerical methodology which depends upon binary integer linear programming, constrained by weak bus measurement is proposed in this paper. Also, the effect of a single PMU loss considering weak buses is shown. The developed approach has been conducted on standard IEEE -14, -118, -300 and New England 39- bus test systems. Finally, obtained results and comparison with different weak bus methodologies are shown and examined.
Patented Innovation and Firm Value in the U.S. Food and Drink Industry: The Economic Importance of High-Quality Product Innovation
Authors: Grashuis Jasper , Dary Stanley 
Published: September 2017

Abstract
We use patent data to study product, process, and marketing innovation in the food and drink industry. From 1994 to 2005, only 61 of 194 U.S. public food and drink manufacturers patented some type of innovation. Furthermore, we find patent ownership is most common to large corporations, and most patented innovations relate to new designs and processes as opposed to new products. According to our empirical panel analysis, however, stock market investors find patent ownership of new product innovations the most valuable, although the intensity of patent ownership is not of utmost importance. Instead, we conclude patent quality is better able to explain variability in the stock market valuation of U.S. food and drink manufacturers. Specifically, a one-percent increase in the quality of patented innovations in food and drink products facilitates a 0.07 % increase in firm value, corresponding to almost $6 million for the mean innovating firm in the U.S. public food and drink industry.
Reading Experience: William James and Robert Browning
Authors: Erchinger Philipp 
Published: September 2017

AbstractThe topic of this essay is the concept of experience which, in the field of literary studies, is often used as if it were divided into an objective and a subjective aspect. Advocates of so-called ›empirical‹ approaches to the study of texts and minds tend to proceed from experience only to abstract impersonal (or objective) ›data‹ from it. By contrast, phenomenological and hermeneutic methods are frequently said to work through more immediately personal (or subjective) responses to, and engagements with, literary works. Thus experience, it seems, must either be read in terms of statistical diagrams and brain images, or else remain caught up in an activityDrawing on the radical empiricism of William James, this essay seeks to reintegrate the experience of reading and the reading of experience, both of which are ambiguously condensed in my title. The main argument of the piece therefore hinges on James’s and John Dewey’s claim that experience is »double-barrelled« (James 1977, 172), which is to say that it refers to »the entire process of phenomena«, to quote James’s own definition, »before reflective thought has analysed them into subjective and objective aspects or ingredients« (James 1978, 95). Made up of both perceptions and conceptions, experience, as James views it, is the medium through which everything must have passed before it can be named, and without (or outside of) which nothing, therefore, can be said to exist. With this radical account of empiricism in mind, I revisit some of the assumptions underpinning cognitive literary criticism, before turning to an interpretation of the dramatic poetry of Robert Browning, which has been described as a version of »empiricism in literature« because it is concerned with »the pursuit of experience in all its remotest extensions« (Langbaum 1963, 96).More specifically, my article engages with »Fra Lippo Lippi« and »An Epistle Containing the Strange Medical Experience of Karshish, the Arab Physician« in order to show that Browning’s dramatic monologues make experience legible as an activity by means of which perceptions come to be turned into conceptions while conceptions, conversely, are continuously reaffirmed, altered, or enriched by whatever perceptions are added to them as life goes on. As I argue, Browning’s
MODY in Ukraine: genes, clinical phenotypes and treatment
Authors: Globa Evgenia , Zelinska Nataliya , Elblova Lenka , Dusatkova Petra , Cinek Ondrej , Lebl Jan , Colclough Kevin , Ellard Sian , Pruhova Stepanka 
Published: September 2017

AbstractBackground:Maturity-onset diabetes of the young (MODY) has not been previously studied in Ukraine. We investigated the genetic etiology in a selected cohort of patients with diabetes diagnosed before 18 years of age, and in their family members.Methods:Genetic testing of the most prevalent MODY genes (Results:A genetic diagnosis of MODY was made in 15/39 affected individuals from 12/36 families (33%).Conclusions:Genetic testing identified pathogenic
Bayesian comparison of protein structures using partial Procrustes distance
Authors: Ejlali Nasim , Faghihi Mohammad Reza , Sadeghi Mehdi 
Published: September 2017

AbstractAn important topic in bioinformatics is the protein structure alignment. Some statistical methods have been proposed for this problem, but most of them align two protein structures based on the global geometric information without considering the effect of neighbourhood in the structures. In this paper, we provide a Bayesian model to align protein structures, by considering the effect of both local and global geometric information of protein structures. Local geometric information is incorporated to the model through the partial Procrustes distance of small substructures. These substructures are composed of
Temperature-controlled formation of Anderson-type compounds and their conversion to [γ-Mo8O26]4−-based variants using pendent ligands
Authors: Tian Ai-xiang , Li Ting-ting , Tian Yan , Ni Huai-ping , Ji Xue-bin , Liu Jia-ni , Liu Guo-cheng , Ying Jun 
Published: September 2017

Abstract
By tuning the reaction temperature, two Anderson- and two [γ-Mo8O26]4−-based compounds decorated by pendent organic ligands, [CuII
9(bpz)2(pz)2(H2O)24][H2(Cr(OH)5Mo6O19)4]·11H2O (1), [CuII(bpz)2(H2O)2(γ-H4Mo8O26)]·2H2O (2), [CuII
2(tea)2(H2O)6(HCr(OH)6Mo6O18)2]· 6H2O (3) and [AgI(bpz)(H2O)(γ-H4Mo8O26)0.5] (4) (bpz=4-butyl-1H-pyrazole, pz=1H-pyrazole, tea=2-[1,2,4]triazol-4-yl-ethylamine), have been hydrothermally synthesized and characterized by single-crystal X-ray diffraction analysis, IR spectra and elemental analyses. In compound 1, there are two kinds of tri-nuclear CuII clusters induced by bpz and pz ligands, respectively. Four Anderson-type anions are linked by these tri-nuclear clusters to form a “W”-type subunit. In compound 2, the [Cu(bpz)2(H2O)2]2+ subunits connect the γ-Mo8 anions to construct a chain. The remaining two non-coordinated N donors in [Cu(bpz)2(H2O)2]2+ further link two adjacent γ-Mo8 anions through Mo–N bonds. In compound 3, there exists a bi-nuclear CuII cluster [Cu2(tea)2(H2O)6]4+. The discrete bi-nuclear CuII clusters and the CrMo6 anions link each other through abundant hydrogen bonding interactions. In compound 4, the [Ag(bpz)(H2O)]+ subunits connect γ-Mo8 anions to build a zigzag chain. The chains are further fused by other [Ag(bpz)(H2O)]+ cations to form a grid-like layer. There still exist Mo–N bonds in 4. We also have investigated the electrochemical and photocatalytic properties of 1–4.
Influences of NH4F additive and calcination time on the morphological evolution of α-Al2O3 from a milled γ-Al2O3 precursor
Authors: Zhu Lingling , Sun Chunhui , Chen Liugang , Lu Xifeng , Li Sai , Ye Guotian , Liu Luoqiang 
Published: September 2017

Abstract
The influences of an NH4F additive content and calcination time on the morphological evolution of α-Al2O3 were investigated by using commercial γ-Al2O3 precursor as raw material. The results showed that the morphological evolution of α-Al2O3 was highly related to the addition of NH4F, the additive content, and the calcination time. Square-like α-Al2O3 powders with a primary crystal size of ~200 nm were formed from the milled γ-Al2O3 precursor with 1 wt.% NH4F at 1300°C for 2 h, whereas round cake-like, hexagonal platelets, slender-like, and other irregularly shaped α-Al2O3 pieces in the size range of 0.2–2 μm were synthesized from the milled γ-Al2O3 precursor with 20 wt.% NH4F addition under the same calcination. Both morphological regularity and particle size distribution of α-Al2O3 were greatly facilitated by increasing the calcination time from 2 to 5 h. The addition of NH4F may lead to an alteration of the α-Al2O3 growth process by a change in the scale of the developing microstructure.
Design and Evaluation of a Moisture/Suction TDR Probe
Authors: Zhang Nan , Yu Xinbao , Puppala Anand 
Published: September 2017

Abstract
Soil moisture content and suction are two key geotechnical properties that are commonly measured by separate moisture and suction sensors, which require double installation efforts and often result in questionable correlation between the measured moisture content and suction. In this study, attempts were made to combine time domain reflectometry (TDR) technique and porous gypsum block functioning as a tensiometer for simultaneous measurements of soil moisture content and suction. A new moisture/suction TDR probe was designed and evaluated in the laboratory. The TDR probe had two parts with one half portion embedded in a gypsum block whose suction is equilibrated with surrounding soils for soil suction measurement. The other half portion of the TDR probe was also inserted into soils to measure moisture content. The probe was calibrated by the pressure plate and filter paper tests to establish a relationship between suction (ψ) and dielectric constant (Ka) of the gypsum block for suction measurement. Three laboratory tests (i.e., staged-drying tests, absorption tests, and desorption tests) were then performed on a silty sand to evaluate the probe performance. It is demonstrated that the probe can measure the soil moisture content and suction satisfactorily in the range 50 kPa &lt; ψ &lt; 10,000 kPa with a response time less than 5 h. Additionally, the probe is fabricated easily and fast, without any additional maintenance, and has a great potential for field measurements of soil moisture content and suction.
Consolidation and Dynamic Response of a Layered Mine Tailings Deposit in Centrifuge Tests
Authors: Antonaki Nonika , Abdoun Tarek , Sasanakul Inthuorn 
Published: September 2017

Abstract
Tailings from a mining project located in a seismically active region were used to construct and test a layered deposit on the geotechnical centrifuge at the Center for Earthquake Engineering Simulation (CEES) at Rensselaer Polytechnic Institute (RPI). A set of six centrifuge tests was conducted to evaluate consolidation rate, settlement accumulation, shear strength evolution, and response to seismic loading. The material was liquid at disposal, so instrumentation of every layer proved to be a challenge. A total height of about 30 m of mine tailings was deposited in prototype scale (80 g). Brief consolidation of each layer took place at a lower centrifugal acceleration, thus enabling the material to gain some strength and facilitating instrumentation, while simultaneously modeling a few days between disposal of subsequent layers. Miniature pore pressure transducers were used to measure water pressure and settlement, bender elements for shear wave velocity, linear variable differential transformers (LVDTs) for displacement, and miniature accelerometers for dynamic loading. The complete deposit consolidated at 80 g for more than two years in prototype scale, but most settlement, excess pore pressure dissipation, and stiffness increase occurred within the first 0.5 years. A mild slope was excavated at the surface after consolidation and the deposit was then subjected to a moderately strong harmonic motion consisting of 50 cycles. Signs of liquefaction were detected in the pore pressure, acceleration and lateral displacement readings up to mid-depth, and the slope was somewhat flattened after dynamic loading.
A Bimolecular Fluorescence Complementation Tool for Identification of Protein-Protein Interactions in Candida albicans
Authors: Subotić Ana , Swinnen Erwin , Demuyser Liesbeth , De Keersmaecker Herlinde , Mizuno Hideaki , Tournu Hélène , Van Dijck Patrick 
Published: September 2017

Abstract
Investigation of protein-protein interactions (PPI) in Candida albicans is essential for understanding the regulation of the signal transduction network that triggers its pathogenic lifestyle. Unique features of C. albicans, such as its alternative codon usage and incomplete meiosis, have enforced the optimization of standard genetic methods as well as development of novel approaches. Since the existing methods for detection of PPI are limited for direct visualization of the interacting complex in vivo, we have established a bimolecular fluorescence complementation (BiFC) assay in C. albicans, a powerful technique for studying PPI. We have developed an optimized set of plasmids that allows for N- and C-terminal tagging of proteins with split yeast-enhanced monomeric Venus fragments, so that all eight combinations of fusion orientations can be analyzed. With the use of our BiFC assay we demonstrate three interaction complexes in vivo, which were also confirmed by two-hybrid analysis. Our Candida-optimized BiFC assay represents a useful molecular tool for PPI studies and shows great promise in expanding our knowledge of molecular mechanisms of protein functions.
Cross-Species Y Chromosome Function Between Malaria Vectors of the Anopheles gambiae Species Complex
Authors: Bernardini Federica , Galizi Roberto , Wunderlich Mariana , Taxiarchi Chrysanthi , Kranjc Nace , Kyrou Kyros , Hammond Andrew , Nolan Tony , Lawniczak Mara N K , Papathanos Philippos Aris , Crisanti Andrea , Windbichler Nikolai 
Published: September 2017

Abstract
Y chromosome function, structure and evolution is poorly understood in many species, including the Anopheles genus of mosquitoes—an emerging model system for studying speciation that also represents the major vectors of malaria. While the Anopheline Y had previously been implicated in male mating behavior, recent data from the Anopheles gambiae complex suggests that, apart from the putative primary sex-determiner, no other genes are conserved on the Y. Studying the functional basis of the evolutionary divergence of the Y chromosome in the gambiae complex is complicated by complete F1 male hybrid sterility. Here, we used an F1 × F0 crossing scheme to overcome a severe bottleneck of male hybrid incompatibilities that enabled us to experimentally purify a genetically labeled A. gambiae Y chromosome in an A. arabiensis background. Whole genome sequencing (WGS) confirmed that the A. gambiae Y retained its original sequence content in the A. arabiensis genomic background. In contrast to comparable experiments in Drosophila, we find that the presence of a heterospecific Y chromosome has no significant effect on the expression of A. arabiensis genes, and transcriptional differences can be explained almost exclusively as a direct consequence of transcripts arising from sequence elements present on the A. gambiae Y chromosome itself. We find that Y hybrids show no obvious fertility defects, and no substantial reduction in male competitiveness. Our results demonstrate that, despite their radically different structure, Y chromosomes of these two species of the gambiae complex that diverged an estimated 1.85 MYA function interchangeably, thus indicating that the Y chromosome does not harbor loci contributing to hybrid incompatibility. Therefore, Y chromosome gene flow between members of the gambiae complex is possible even at their current level of divergence. Importantly, this also suggests that malaria control interventions based on sex-distorting Y drive would be transferable, whether intentionally or contingent, between the major malaria vector species.