bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation
Authors: Hong Zhiwei , Feng Yuming , Ding Hualong , Hu Xuechun , Lu Jin-Chun , Ge Xie , Ge Yifeng , Yao Bing 
Published: January 2017

Abstract

Introduction
Hyperactivity of the sympathetic nervous system can play an important role in lifelong premature ejaculation (PE). Our previous study found that amyloid precursor protein (APP) levels in seminal plasma of patients with PE were clearly increased. Amyloid-β (Aβ) is derived from APP. Excessive Aβ, especially Aβ42, can cause neuronal dysfunction.

Aim
To determine whether APP and Aβ42 are associated with an abnormal penile sympathetic skin response (PSSR).

Methods
From November 2015 to April 2016, 24 patients with lifelong PE (mean age = 29.2 ± 5.3) with self-estimated intravaginal ejaculatory latency time no longer than 2 minutes and 10 control subjects (mean age = 28.0 ± 5.5) were enrolled consecutively from andrology clinics. PSSR was measured in patients with lifelong PE. APP and Aβ42 levels in seminal plasma were determined.

Main Outcome Measures
PSSR in patients with lifelong PE and APP and Aβ42 levels in all subjects.

Results
Patients with PE presented 1.5-fold higher levels of APP (P = .004) than control subjects. Seminal plasma protein concentration (C) in the PE group was lower than that in the control group (P = .007). APP divided by C (APP/C) was 2.0-fold higher (P &lt; .001) in the PE group. Aβ42 level was not different between the PE and control groups, but Aβ42 divided by C (Aβ42/C) was significantly higher in the PE group (P &lt; .001). No differences in APP and APP/C were found between patients with PE in the abnormal and normal PSSR groups. The abnormal PSSR group presented significantly higher Aβ42 (P = .007) and Aβ42/C (P &lt; .001) levels. The latency of PSSR was negatively correlated with Aβ42/C (r = −0.436; P = .033).

Conclusion
These results showed that patients with lifelong PE had higher APP and Aβ42 levels in seminal plasma. Abnormal PSSR was related to a higher Aβ42 level. Drugs that decrease Aβ could be treatment of PE.
From Marx to Market: The Debates on the Economic System in Vietnam’s Revised Constitution
Authors: PHAM Duy Nghia 
Published: January 2017

AbstractThis article analyzes the socio-economic and political contexts behind the2013 Constitution of the Socialist Republic of Vietnam(2013 Constitution), in which demands for deeper institutional reform emerged in Vietnam, and explains the constitutional discourse within Vietnam as to its economic order. Diverse forces and platforms within Vietnam’s party-state and beyond have contributed to the exchange of ideas and values on the economic order. As a result of this public discourse, the provisions on the economic order of the 2013 Constitution are ideological compromises, reflecting the contradicting views within the party-state and society in Vietnam on the role of the market, private property, and the freedom to conduct business. The 2013 Constitution has taken a step towards a free market economy by recognizing the decisive role of the market in the national economy. It emphasizes the importance of the private sector and promises that it will be treated fairly among all other economic sectors. From this perspective, the 2013 Constitution contains the seeds of future political and legal guarantees which could protect individual liberties. However, in line with the socialist ideology adopted by its predecessors, the 2013 Constitution reaffirms the dominance of the public sector and the leading role of state-owned enterprises, and preserves the ambiguous “ownership of the entire Vietnamese people of land and natural resources”. Due to this ambiguity, the 2013 Constitution fails to lay down the foundations for far-reaching comprehensive institutional reforms that Vietnam urgently requires.
Constitutional Debate and Development on Human Rights in Vietnam
Authors: VU Giao Cong , TRAN Kien 
Published: January 2017

AbstractThis article analyzes the constitutional debate on and development of human rights in Vietnam throughout five constitutions from 1946 to 2013, as well as the prospects and challenges in promoting human rights in Vietnam during and after the development of its 2013 Constitution. It begins with an investigation and discussion of the human rights provisions from the 1946 Constitution to the 1992 Constitution – a period where the socialist human rights tradition was established in Vietnam. It follows with an analysis of the debates on the new human rights and citizens’ rights provisions in the 1992 Constitution, where a new concept of natural human rights emerged. The article continues to explore how the struggle and debates surrounding the competing conception of rights – socialist and positivist on one hand and natural law-based on the other – come into play in shaping the 2013 Constitution. It then proceeds to evaluate the potential challenges involved in the implementation of these rights in the coming years. The authors argue that the development of constitutional human rights in Vietnam is still limited by ideological barriers. It also faces substantial practical challenges owing to, inter alia, the absence of provisions for the immediate implementation of such rights as well as legal mechanisms for the protection of constitutional rights, such as a constitutional review system.
Vision in fossilised eyes
Authors: Schoenemann Brigitte , Clarkson Euan N. K. 
Published: January 2017

ABSTRACTThis paper presents a review of recent developments in the study of vision in fossil arthropods, beginning with a discussion of the origin of visual systems. A report of the eyes of Cambrian arthropods from different Lagerstätten, especially the compound and median arthropod eyes from the Chengjiang fauna of China, is given. Reference is made also to compound eyes from the lower Cambrian Emu Bay Shale fauna of Australia and the Sirius Passet fauna of Greenland; also to the three-dimensionally preserved ‘Orsten’ fauna of Sweden. An understanding of how these eyes functioned is possible by reference to living arthropods and by using physical tools developed by physiologists. The eyes of trilobites (lower Cambrian to Upper Permian) are often very well preserved, and the structure and physiology of their calcite lenses, and the eye as a whole, are summarised here, based upon recent literature. Two main kinds of trilobite eyes have been long known. Firstly, there is the holochroal type, in which the lenses are usually numerous, small and closely packed together; this represents the ancestral kind, first found in lowermost Cambrian trilobites. The second type is the schizochroal eye, in which the lenses are relatively much larger and each is separated from its neighbours. Such eyes are confined to the single suborder Phacopina (Lower Ordovician to Upper Devonian). This visual system has no real equivalents in the animal kingdom. In this present paper, the origin of schizochroal eyes, by paedomorphosis from holochroal precursors, is reviewed, together with subsequent evolutionary transitions in the Early Ordovician. A summary of new work on the structure and mineralogy of phacopid lenses is presented, as is a discussion of the recent discovery of sublensar sensory structures in Devonian phacopids, which has opened up new dimensions in the study of trilobite vision.
BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
Authors: Qi Zhen , Li Yehua , Zhao Bing , Xu Chi , Liu Yuan , Li Haonan , Zhang Bingjie , Wang Xinquan , Yang Xiao , Xie Wei , Li Baojie , Han Jing-Dong Jackie , Chen Ye-Guang 
Published: January 2017

AbstractThe intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5+ stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of intestinal epithelium, but the exact mechanism remains elusive. Here we demonstrate that epithelial BMP signalling plays an indispensable role in restricting Lgr5+ stem cell expansion to maintain intestinal homeostasis and prevent premalignant hyperproliferation on damage. Mechanistically, BMP inhibits stemness of Lgr5+ stem cells through Smad-mediated transcriptional repression of a large number of stem cell signature genes, including Lgr5, and this effect is independent of Wnt/β-catenin signalling. Smad1/Smad4 recruits histone deacetylase HDAC1 to the promoters to repress transcription, and knockout of Smad4 abolishes the negative effects of BMP on stem cells. Our findings therefore demonstrate that epithelial BMP constrains the Lgr5+ stem cell self-renewal via Smad-mediated repression of stem cell signature genes to ensure proper homeostatic renewal of intestinal epithelium.
CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
Authors: Zhou Jin , Wu Zhong , Wong Gabrielle , Pectasides Eirini , Nagaraja Ankur , Stachler Matthew , Zhang Haikuo , Chen Ting , Zhang Haisheng , Liu Jie Bin , Xu Xinsen , Sicinska Ewa , Sanchez-Vega Francisco , Rustgi Anil K. , Diehl J. Alan , Wong Kwok-Kin , Bass Adam J. 
Published: January 2017

AbstractOesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations pointing to candidate therapeutic targets, including recurrent amplification of the gene encoding receptor tyrosine kinase epidermal growth factor receptor (EGFR). Here, we demonstrate that EGFR-targeting small-molecule inhibitors have efficacy in EGFR-amplified oesophageal squamous cell carcinoma (ESCC), but may become quickly ineffective. Resistance can occur following the emergence of epithelial–mesenchymal transition and by reactivation of the mitogen-activated protein kinase (MAPK) pathway following EGFR blockade. We demonstrate that blockade of this rebound activation with MEK (mitogen-activated protein kinase kinase) inhibition enhances EGFR inhibitor-induced apoptosis and cell cycle arrest, and delays resistance to EGFR monotherapy. Furthermore, genomic profiling shows that cell cycle regulators are altered in the majority of EGFR-amplified tumours and a combination of cyclin-dependent kinase 4/6 (CDK4/6) and EGFR inhibitors prevents the emergence of resistance in vitro and in vivo. These data suggest that upfront combination strategies targeting EGFR amplification, guided by adaptive pathway reactivation or by co-occurring genomic alterations, should be tested clinically.
Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
Authors: Li Xia , Wang Xiupeng , Zhang Jun , Hanagata Nobutaka , Wang Xuebin , Weng Qunhong , Ito Atsuo , Bando Yoshio , Golberg Dmitri 
Published: January 2017

AbstractHigh global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compounds is hampered by their short half-life and low effectiveness. Here we report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumour mouse models treated with BN spheres demonstrated significant suppression of tumour growth. An orthotopic tumour growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. Moreover, the administration of hollow BN spheres with paclitaxel leads to synergetic effects in the suppression of tumour growth. The work demonstrates that hollow BN spheres may function as a new agent for prostate cancer treatment.
Reorientation of the diagonal double-stripe spin structure at Fe1+yTe bulk and thin-film surfaces
Authors: Hänke Torben , Singh Udai Raj , Cornils Lasse , Manna Sujit , Kamlapure Anand , Bremholm Martin , Hedegaard Ellen Marie Jensen , Iversen Bo Brummerstedt , Hofmann Philip , Hu Jin , Mao Zhiqiang , Wiebe Jens , Wiesendanger Roland 
Published: January 2017

AbstractEstablishing the relation between ubiquitous antiferromagnetism in the parent compounds of unconventional superconductors and their superconducting phase is important for understanding the complex physics in these materials. Going from bulk systems to thin films additionally affects their phase diagram. For Fe1+yTe, the parent compound of Fe1+ySe1−xTex superconductors, bulk-sensitive neutron diffraction revealed an in-plane oriented diagonal double-stripe antiferromagnetic spin structure. Here we show by spin-resolved scanning tunnelling microscopy that the spin direction at the surfaces of bulk Fe1+yTe and thin films grown on the topological insulator Bi2Te3 is canted out of the high-symmetry directions of the surface unit cell resulting in a perpendicular spin component, keeping the diagonal double-stripe order. As the magnetism of the Fe d-orbitals is intertwined with the superconducting pairing in Fe-based materials, our results imply that the superconducting properties at the surface of the related superconducting compounds might be different from the bulk.
TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer
Authors: Hai Josephine , Zhu Chang-Qi , Wang Tao , Organ Shawna L. , Shepherd Frances A. , Tsao Ming-Sound 
Published: January 2017

AbstractNon-small-cell lung carcinoma (NSCLC) accounts for 85% of malignant lung tumors and is the leading cause of cancer deaths. Our group previously identified Tripartite Motif 14 (TRIM14) as a component of a prognostic multigene expression signature for NSCLC. Little is known about the function of TRIM14 protein in normal or disease states. We investigated the functional and prognostic role of TRIM14 in NSCLC using in vitro and in vivo perturbation model systems. Firstly, a pooled RNAi screen identified TRIM14 to effect cell proliferation/survival in NSCLC cells. Secondly, silencing of TRIM14 expression significantly enhanced tumor growth in NSCLC xenograft mouse models, while exogenous TRIM14 expression attenuated tumorigenesis. In addition, differences in apoptotic activity between TRIM14-deficient and control tumors suggests that TRIM14 tumor suppressor activity may depend on cell death signaling pathways. TRIM14-deficient cell lines showed both resistance to hypoxia-induced cell death and attenuation of interferon response via STAT1 signaling. Consistent with these phenotypes, multivariate analyses on published mRNA expression datasets of over 600 primary NSCLCs demonstrated that low TRIM14 mRNA levels are significantly associated with poorer prognosis in early stage NSCLC patients. Our functional data therefore establish a novel tumor suppressive role for TRIM14 in NSCLC progression.
A Pilot-scale Benthic Microbial Electrochemical System (BMES) for Enhanced Organic Removal in Sediment Restoration
Authors: Li Henan , Tian Yan , Qu Youpeng , Qiu Ye , Liu Jia , Feng Yujie 
Published: January 2017

AbstractA benthic microbial electrochemical systems (BMES) of 195 L (120 cm long, 25 cm wide and 65 cm height) was constructed for sediment organic removal. Sediment from a natural river (Ashi River) was used as test sediments in the present research. Three-dimensional anode (Tri-DSA) with honeycomb structure composed of carbon cloth and supporting skeleton was employed in this research for the first time. The results demonstrated that BMES performed good in organic-matter degradation and energy generation from sediment and could be considered for river sediments in situ restoration as novel method. Community analysis from the soil and anode using 16S rDNA gene sequencing showed that more electrogenic functional bacteria was accumulated in anode area when circuit connected than control system.
The Effect of Electronic Structure on the Phases Present in High Entropy Alloys
Authors: Leong Zhaoyuan , Wróbel Jan S. , Dudarev Sergei L. , Goodall Russell , Todd Iain , Nguyen-Manh Duc 
Published: January 2017

AbstractMulticomponent systems, termed High Entropy Alloys (HEAs), with predominantly single solid solution phases are a current area of focus in alloy development. Although different empirical rules have been introduced to understand phase formation and determine what the dominant phases may be in these systems, experimental investigation has revealed that in many cases their structure is not a single solid solution phase, and that the rules may not accurately distinguish the stability of the phase boundaries. Here, a combined modelling and experimental approach that looks into the electronic structure is proposed to improve accuracy of the predictions of the majority phase. To do this, the Rigid Band model is generalised for magnetic systems in prediction of the majority phase most likely to be found. Good agreement is found when the predictions are confronted with data from experiments, including a new magnetic HEA system (CoFeNiV). This also includes predicting the structural transition with varying levels of constituent elements, as a function of the valence electron concentration, n, obtained from the integrated spin-polarised density of states. This method is suitable as a new predictive technique to identify compositions for further screening, in particular for magnetic HEAs.
A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis
Authors: Kim Min-Hyeok , Yang Dongchan , Kim Mirang , Kim Seon-Young , Kim Dongsup , Kang Suk-Jo 
Published: January 2017

AbstractHomeostasis of neutrophils—the blood cells that respond first to infection and tissue injury—is critical for the regulation of immune responses and regulated through granulopoiesis, a multi-stage process by which neutrophils differentiate from hematopoietic stem cells. Granulopoiesis is a highly dynamic process and altered in certain clinical conditions, such as pathologic and iatrogenic neutropenia, described as demand-adapted granulopoiesis. The regulation of granulopoiesis under stress is not completely understood because studies of granulopoiesis dynamics have been hampered by technical limitations in defining neutrophil precursors. Here, we define a population of neutrophil precursor cells in the bone marrow with unprecedented purity, characterized by the lineage−CD11b+Ly6GloLy6BintCD115−, which we call NeuPs (Neutrophil Precursors). We demonstrated that NeuPs differentiate into mature and functional neutrophils bothin vitroandin vivo. By analyzing the gene expression profiles of NeuPs, we also identified NeuP stage-specific genes and characterized patterns of gene regulation throughout granulopoiesis. Importantly, we found that NeuPs have the potential to proliferate, but the proliferation decreased in multiple different hematopoietic stress settings, indicating that proliferating NeuPs are poised at a critical step to regulate granulopoiesis. Our findings will facilitate understanding how the hematopoietic system maintains homeostasis and copes with the demands of granulopoiesis.
The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea
Authors: Wei Shyh-Yuh , Chen Li-Fen , Lin Ming-Wei , Li Wei-Chi , Low Intan , Yang Ching-Ju , Chao Hsiang-Tai , Hsieh Jen-Chuen 
Published: January 2017

AbstractThe mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the OPRM1 A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This OPRM1 A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.
Obtaining control of cell surface functionalizations via Pre-targeting and Supramolecular host guest interactions
Authors: Rood Mark T. M. , Spa Silvia J. , Welling Mick M. , ten Hove Jan Bart , van Willigen Danny M. , Buckle Tessa , Velders Aldrik H. , van Leeuwen Fijs W. B. 
Published: January 2017

AbstractThe use of mammalian cells for therapeutic applications is finding its way into modern medicine. However, modification or “training” of cells to make them suitable for a specific application remains complex. By envisioning a chemical toolbox that enables specific, but straight-forward and generic cellular functionalization, we investigated how membrane-receptor (pre)targeting could be combined with supramolecular host-guest interactions based on β-cyclodextrin (CD) and adamantane (Ad). The feasibility of this approach was studied in cells with membranous overexpression of the chemokine receptor 4 (CXCR4). By combining specific targeting of CXCR4, using an adamantane (Ad)-functionalized Ac-TZ14011 peptide (guest; KD = 56 nM), with multivalent host molecules that entailed fluorescent β-CD-Poly(isobutylene-alt-maleic-anhydride)-polymers with different fluorescent colors and number of functionalities, host-guest cell-surface modifications could be studied in detail. A second set of Ad-functionalized entities enabled introduction of additional surface functionalities. In addition, the attraction between CD and Ad could be used to drive cell-cell interactions. Combined we have shown that supramolecular interactions, that are based on specific targeting of an overexpressed membrane-receptor, allow specific and stable, yet reversible, surface functionalization of viable cells and how this approach can be used to influence the interaction between cells and their surroundings.
Incommensurate Graphene Foam as a High Capacity Lithium Intercalation Anode
Authors: Paronyan Tereza M. , Thapa Arjun Kumar , Sherehiy Andriy , Jasinski Jacek B. , Jangam John Samuel Dilip 
Published: January 2017

AbstractGraphite’s capacity of intercalating lithium in rechargeable batteries is limited (theoretically, 372 mAh g−1) due to low diffusion within commensurately-stacked graphene layers. Graphene foam with highly enriched incommensurately-stacked layers was grown and applied as an active electrode in rechargeable batteries. A 93% incommensurate graphene foam demonstrated a reversible specific capacity of 1,540 mAh g−1 with a 75% coulombic efficiency, and an 86% incommensurate sample achieves above 99% coulombic efficiency exhibiting 930 mAh g−1 specific capacity. The structural and binding analysis of graphene show that lithium atoms highly intercalate within weakly interacting incommensurately-stacked graphene network, followed by a further flexible rearrangement of layers for a long-term stable cycling. We consider lithium intercalation model for multilayer graphene where capacity varies with N number of layers resulting LiN+1C2N stoichiometry. The effective capacity of commonly used carbon-based rechargeable batteries can be significantly improved using incommensurate graphene as an anode material.