bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of electro-acupuncture on postpartum urinary retention —— A protocol for multicenter, randomized and placebo-controlled trial
Authors: Dou Zhen , Zhang Yunzhi , Cui Hongyan , Zhao Xiaoli , Dai Lijing , wang Baojuan , Fu Yu , Xia Tian , Chang Ying 
Published: October 2024

Abstract

Background
Postpartum urinary retention (PUR) is one of the serious and common clinical complications after delivery. Although urinary catheterization can provide temporary relief from voiding disorders, it may cause discomfort, pain, and even urethral injury to the mother, thereby increasing the risk of urinary system infection. Acupuncture was shown it has unique advantages in relieving the clinical symptoms of PUR, promoting bladder recovery. However, there is not sufficient high-quality evidence to strongly support the effectiveness of electroacupuncture in the prevention and treatment of PUR. Therefore, we have designed a multi-center, large-sample, randomized controlled clinical trial to assess the impact of electroacupuncture intervention on the incidence of PUR and the recovery of bladder function.
Methods
This is a multicenter, randomized, parallel-group clinical trial conducted in China to investigate the impact of electroacupuncture intervention on the incidence of PUR. Patient screening and enrollment will take place at four hospitals in China: the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Shuige Hospital and Second People's Hospital of Fengrun District, Tangshan City. Patients will be randomly assigned to either the electroacupuncture group or the sham acupuncture group, with 330 patients in each group. Each acupuncture treatment will comprise three 30-minute sessions over 2 days (the first hour, the first day, and the second day after delivery). The primary outcome measure is the incidence of PUR. Adverse events will be recorded, and their impact will be analyzed at the end of the trial.
Discussion
This study will provide high-quality evidence support for the effectiveness of electroacupuncture in preventing and treating PUR, and provide scientific basis for the application of non-drug therapy in postpartum rehabilitation.
Trial registration
ClinicalTrials.gov: ChiCTR2300078039.Registered on 27 November 2023.
Comparing the effects of treadmill training versus Baduanjin on prefrontal cortical activity during dual-task walking in Parkinson’s disease: Study protocol using a fNIRS device
Authors: Hui Juan , Li Zhenlan , Xu Shanshan , Yu Junwu , Tang Min , Zhou Lifeng 
Published: October 2024

Abstract

Background:
Patients with Parkinson’s disease (PD) have shown impaired gait rhythmicity and increased prefrontal activation during complex tasks, presumably to compensate for decreased automaticity. Exercise can reduce cortical excitability and enhance automaticity, thereby improving walking function. However, the effectiveness of treadmill training and Baduanjin on prefrontal activity has received little attention when patients with PD walk under different dual-task conditions. This randomized control trial (RCT) will investigate the comparative effects of treadmill training and Baduanjin on prefrontal activation and gait function during both single and dual tasks in PD.
Methods:
This RCT will be designed as a single-center, three-arm, single-blind study. One hundred and forty-four participants will be allocated into treadmill training, Baduanjin, or waitlist control groups. Participants in both the treadmill training and Baduanjin groups will receive 45 min of specific exercise three times weekly for 12 weeks. Participants in the control groups will maintain routine care and lifestyle. The primary and secondary outcomes will be assessed at baseline, after a 12-week intervention, and at the end of a12-week follow-up. The primary outcomes will be prefrontal activation (oxygenated hemoglobin concentration, HbO2) measured by functional near-infrared spectroscopy (fNIRS), and gait parameters (gait speed, stride length, double-phase time, stride variability, and step width) assessed by an electronic walkway with pressure sensors. The secondary outcomes will be motor function, balance, mobility, and quality of life.
Discussion:
This study will determine whether treadmill training or Baduanjin is more effective in reducing prefrontal activation and improving gait function. If the findings are consistent with our expectations, they may help clinicians and physical therapists to manage gait impairments in patients with PD and to select targeted interventions for them.
Trial registration
http//www.chictr.org.cn. Trial number ChiCTR2300075048. Registered on 23 Aug 2023.
Critical sustainability events and perceived roles of academic leaders at a leading university in sustainability: CIT case study
Authors: Veidemane Anete , Crăciun Daniela , Meulen Barend van der 
Published: October 2024

Abstract

This case study explores the perceived roles of academic leaders in critical sustainability events at a leading university in sustainability - the University of Auckland (UoA). UoA was selected due to its high position in the Times Higher Education (THE) Impact Ranking (1st in 2019 and 2020) based on its contribution to Sustainable Development Goals (SDGs). Employing the critical incident technique (CIT) through semi-structured interviews, university staff were asked to reflect on the meaning of a sustainable university, critical sustainability events, and the roles of academic leaders in these events. Both central-level and faculty-level leadership were considered. The interviews revealed that while a multi-dimensional and holistic vision of a sustainable university is beneficial for engaging diverse stakeholders, three transformation tensions emerge as the discussion moves from a vision to implementation: priorities (competing sustainability dimensions), pace (desired speed of transformation), and process (desired consultation for transformation). These tensions are displayed in the Triangle of Transformation Tensions. In total, 16 critical events (CEs) were identified by staff predominantly (81%) occurring within the last five years (2019–2023). The majority were internal CEs, initiated by the university (75%) while the two most frequent CEs were external– COVID-19 and THE Impact Ranking. Central-level strategies and policies (e.g., sustainability strategy, flight policy) represented the most common type of CE (25%). Yet these CEs should not be viewed in isolation. Often most recalled CEs, highly visible and centralised, were underpinned by less prominent CEs (e.g., data monitoring). Moreover, the recent change in the central-level leadership, though less frequently recalled as a CE (10%), was mentioned by the majority of interviewees (> 60%). The perceived roles of academic leaders were conceptualised into five categories: no role, support, drive, divert and block, ranging from passive to active leadership roles. The study hypothesizes that staff associate visible leadership roles with invisible leadership stances, which depend on competing priorities, including intrinsic values, external opportunities & pressures, and resource & authority constraints. No single role is optimal in every situation. Rather each role can be utilised to address the transformation tensions (priorities, pace, process) in various ways.
Modified anterior rectopexy – clinical and radiological outcomes in patients with combined defects in the posterior pelvic compartment
Authors: Melvas Bjarne , Kurlberg Goran , Borjesson Lars 
Published: October 2024

Abstract

Background
Different types of posterior pelvic organ prolapse (PPOP; rectal prolapse, rectocele or enterocele) often coexist and can be associated with overlapping symptoms. This study introduces a modified laparoscopic anterior rectopexy, laparoscopic vaginorectopexy (LVRP), for the correction of multiple PPOP in a single procedure. The focus is on bowel function, recurrence rates and complications.
Methods
Twenty-five women with symptoms of obstructed defecation (OD) and more than one PPOP were prospectively included and assessed with clinical examination, defecography and a questionnaire for bowel function and quality of life (QoL). During LVRP, a t-shaped mesh was sutured to the pelvic muscles, vagina and sacrouterine ligaments and then stapled to the promontory; the mesorectum was stapled to the mesh. Follow up was scheduled twelve months after the procedure and long term (minimum ten years).
Results
One patient suffered from mesh erosion and another from postoperative bleeding. Outcomes after twelve months were: no recurrence of internal or external rectal prolapse; three rectoceles and one enterocele recurred; bowel function and QoL improved for around half of patients; few patients deteriorated. At long term follow up, the effects on OD and QoL were unchanged, but an increase in incontinence was recorded.
Conclusions
LVRP is a technique for the correction of multiple PPOP in a single procedure. The procedure is safe with low recurrence and complication rates. Bowel function and QoL improve over the short term, while the effect on faecal incontinence deteriorates over the long term.
Trial registration no.:
NCT06330857
The expression of TRPM4 protein is increased in the hippocampus of aged PND rats, and ulinastatin affects TRPM4 and apoptosis to enhance cognition dysfunction
Authors: Xia Xiaohui , li Jiayi , Zhang Mengmeng , Zhang Chunyan , Lu Keliang , Han Huirong 
Published: October 2024

Abstract

Background
Transient receptor potential melastatin 4(TRPM4)is a non-selective cation channel that is mainly permeable to Na+, activated by intracellular calcium, and modulated by ATP; Dysregulation of TRPM4 contributes to many pathological processes, including stroke, cerebral edema after traumatic, spinal cord injury and neurodegenerative diseases。TRPM4 plays an important role in neuronal apoptosis and mitochondrial function protection, and we assume that it plays a role in PND. Ulinastatin has been shown to have a protective effect on perioperative neurocognitive function, and we used the group with Ulinastatin as a protective agent for comparison.
Methods
Forty18-month-old male Sprague-Dawley rats were divided into four groups: group C (sham-operated); surgery group (internal fixation of tibial fracture); UTI group (Ulinastatin + surgery), and 9- phenanthrol group (TRPM4 channel inhibitor + surgery). Western blotting, qPC,and IF were used to detect the expression levels of TRPM4 in different groups of rats. The neurocognitive function of rats was detected by the Y-maze and NOR test. The expression of apoptosis-related proteins in rat hippocampal cells was detected, and the apoptosis level of rat hippocampal cells was detected by the TUNEL method. Mitochondrial morphology was observed by transmission electron microscopy.
Results
TRPM4 expression was significantly higher in the hippocampus of rats in the surgery group compared with the sham surgery group. Behavioral assays in the 9-phenanthrol group showed better results than those in the surgery group, with decreased expression of BAX, an apoptosis-related protein, elevated expression of BCL-2, and decreased tunel Apoptosis Index in the hippocampus of rats. The Ulinastatin group and the inhibitor group had similar results.
Conclusion
TRPM4 expression is elevated in the hippocampus of aged PND rats, and inhibition of its expression attenuates hippocampal apoptosis and protects perioperative neurocognitive function in rats, with a similar effect to that of Ulinastatin protection.
Association between microcephaly and hearing disorders in children exposed or suspected of exposure to the Zika virus during the intrauterine period
Authors: Amaral Andrea de Oliveira Campos , de Faria Armanda de Oliveira Pache , Carvalho Fabiana Rabe , Dalcastel Luis Antonio Bataglin , Almeida Simone Saraiva de Abreu , Fernandes Alexandre Ribeiro , Velarde Luis Guillermo Coca , Oliveira Solange Artimos , Cardoso Claudete Aparecida Araújo , Miterhof Maria Elisa Vieira da Cunha Ramos , Vianna Renata Artimos de Oliveira 
Published: October 2024

Abstract

Purpose
This study aimed to evaluate the association between microcephaly and hearing disorders in children with exposed or suspected of exposure to Zika virus (ZIKV) during the intrauterine period.
Methods
This cross-sectional study, we enrolled children exposed or suspected of being exposed to ZIKV and born to mothers with confirmed or suspected ZIKV infection during pregnancy, admitted to the hospital between April 2016 and July 2018, and followed up until September 2021. All children underwent at least one automated auditory brainstem response (AABR) test. For analysis, the patients were divided into four groups: those with microcephaly, without microcephaly, suspected ZIKV infection, and controls. Other causes of microcephaly were excluded. Hearing impairment was assessed using the AABR to determine associations with microcephaly or central nervous system (CNS) abnormalities.
Results
Of the 134 children included, 34 (25.4%) were diagnosed with congenital Zika syndrome (CZS), of whom 28 (82.4%) had microcephaly, and the remaining six (17.6%) without microcephaly. Among the 28 children with microcephaly, 3 (10.7%) had abnormal AABR. Among children without microcephaly (n = 106), 3 (2.8%) had abnormal AABR (p = 0.09).
Conclusion
In our study population, children with and without microcephaly had abnormal AABR.
Infants with bronchiolitis with high-flow nasal cannula in the paediatric ward. Is there a role for the ROXi (Respiratory rate–Oxygenation index) to predict transfer requirement to the PICU?
Authors: Pallec Catline Le , Cerasuolo Damiano , Cauvin Jean Charles , Agossah Cédric , Milesi Christophe , Savy Nadia , Brossier David W. 
Published: October 2024

Abstract

Introduction: The respiratory rate–oxygenation index (ROXi) has been shown to be a reliable tool to predict the risk for HFNC failure in adult patients with lower respiratory tract infections. In paediatrics, the reliability of this index to predict HFNC failure appeared mitigated. In specific population, such as infants with moderate to severe bronchiolitis hospitalized in paediatric ward with HFNC, its ability to predict transfer requirement to the PICU needs to be further evaluated. The main objective of this study was to evaluate the ability of the ROXI collected at initiation of HFNC in the paediatric ward to predict the need for PICU transfer and/or HNFC failure in cases of moderate to severe bronchiolitis.
Methods: A retrospective review of patients aged 0 to 6 months with bronchiolitis who received HFNC within seven tertiary paediatric hospital over the last 5 epidemic seasons from 2018 to 2023 was conducted. Demographic, clinical, and biochemical variables were collected at admission and at the beginning of HFNC therapy support. Initial management and its evolution were described. Patients were compared depending on their transfer to the PICU during hospital stay. HFNC failure was defined as the need for Non-Invasive Ventilation. Multivariable regression analysis was used to determine parameters associated with transfer to the PICU and HFNC failure.
Results: We included 383 infants in this multicentric study (median age 63 days [7; 192]). 76 patients (20%) requiring HNFC were finally transferred to the PICU with a median of 2 days after the hospitalization. Only 40 children (10%) benefited from ventilatory escalation and for children transferred to a PICU, only one patient was intubated. In our population, the optimal ROX index for prediction of PICU requirement and HNFC failure of 6.9 (sensibility 53.1% and specificity 79.8%) and 7.6 (sensibility 62.5% and specificity 66.8%), respectively. In the multivariate analysis, explanatory variables for both transfer to the PICU and HFNC failure were preterm birth, younger age (under 3-month-old), and mWCAS ≥ 3. Besides, SpO2 ≤ 92% at admission and hypotonia were considered as risks factor for transfer and HFNC failure, respectively
Conclusion: HFNC appeared to be a safe tool for the management of moderate to severe bronchiolitis in the paediatric ward. However, it is necessary to identify patients for whom management remains safe in the paediatric ward, and in this context ROXi appears to be an interesting marker.
Predictive Analysis and Data-Driven Approaches for Developing Sustainable Municipal Solid Waste Management Strategies in Smart Cities: A Case Study of Madurai
Authors: Ganesh S. Valai , Suresh V. , Barnabas S. Godwin 
Published: October 2024

Abstract

This study predicts the handling of trash in Madurai Smart City and proposes rules to improve the environment and health. A mixed-methods analysis was conducted using qualitative and quantitative data, including interviews with stakeholders, policy reviews, garbage pickup, processing metrics, and population growth estimates. Predictive analytics tools such as time series forecasting and machine learning models have been used to determine the long-term effectiveness of waste management strategies. Key findings include the placement of trash trucks, encouraging recycling through community involvement programs, and the utilization of creative waste-to-energy systems. This study emphasizes the need for government, people, and technology support for effective waste management. Predictive analysis can aid in strategic planning and dynamic policy decisions, enhance living conditions and make Madurai Smart City more environmentally friendly. This study highlights the importance of the government, people, and technology in implementing effective waste management strategies.
Construction of a nomogram model for predicting peritoneal metastasis in gastric cancer based on ferroptosis-relate genes and clinicopathological features
Authors: Sun Xiaotong , Duan Kaipeng , Shen Xiaochun , Dong Chao , Zhou Yajing , Chen Tao , Li Weikang , Li Peiyuan , Wang Pengbo , Li Dongbao , Zhou Jin 
Published: October 2024

Abstract

Background
Approximately 60% of gastric cancer deaths are caused by gastric cancer peritoneal metastasis (GCPM). GCPM lacks effective early diagnosis methods. We found that ferroptosis-related genes (FRGs) play a vital role in GCPM, but whether FRGs can predict GCPM is still unknown.
Methods
The RNA-Sequencing and clinical data of gastric cancer (GC) patients were downloaded from GSE62254. They were randomly divided into an experimental group and a validation group in a ratio of 3:2. Cox analyses and least absolute shrinkage and selection operator (LASSO) regression were applied in the experimental group to construct a six FRGs-based nomogram model. We evaluate the predictive value of this nomogram for GCPM in both the experimental and validation groups. 115 clinical samples were collected to verify the accuracy of the prediction model using immunohistochemistry (IHC).
Results
LASSO regression calculated six FRGs along with their coefficients, risk score was calculated for each patient. Univariate and multivariate logistic analyses found that the risk score and pathological stage were significantly associated with GCPM. The ROC curve indicated that the risk score had good predictive ability for GCPM (AUC > 0.7). Combining the risk score and TNM stage significantly enhanced the predictive power (AUC > 0.8). We constructed a nomogram with two features: risk score and TNM stage. The Decision Curve Analysis (DCA) curve showed good clinical application. The IHC results from the 115 clinical samples were consistent with the above results.
Conclusion
A ferroptosis-related gene signature was constructed and has impressive predictive values for the peritoneal metastasis of gastric cancer.
Prediction of surface roughness based on the Multi-Input CNN-MHA in milling
Authors: Guo Miaoxian , Wei Shouheng , Han Chentong , Guo Weicheng , Huang Zhiwen 
Published: October 2024

Abstract

In the realm of manufacturing, the prediction of surface roughness during milling processes is of paramount importance as it directly influences product quality, tool life, and manufacturing efficiency. However, current surface roughness prediction methods exhibit limitations, particularly in terms of feature extraction and prediction accuracy. This study introduces a novel surface roughness prediction method based on a hybrid neural network, which uses time-frequency image and feature vector as multiple inputs, and integrates convolution and multi-head self-attention (MHA) mechanism. Initially, the input signals are subjected to noise reduction using Variational Mode Decomposition (VMD), which effectively extracts cleaner signal features. Subsequently, Continuous Wavelet Transform (CWT) is applied to generate time-frequency maps of the signals, providing a rich source of information for the Convolutional Neural Network (CNN). Furthermore, the Multi-Head Attention mechanism is incorporated to enhance the model's comprehension of global signal characteristics. A multi-input hybrid neural network model is constructed, combining CNN with MHA, and utilizing deep learning techniques to decipher complex relationships between features, thereby achieving high-precision prediction of surface roughness. The results show the proposed method significantly outperforms single-input models in predictive accuracy, with a root mean square error (RMSE) of 0.0349 and a maximum absolute error (MaxAE) of 0.0683.
Targeting Phospholipids: Fingolimod's Antibacterial Mechanism Against Staphylococcus aureus
Authors: Shang Yongpeng , Huang Yu , Meng Qingyin , Yu Zhijian , Wen Zewen , Yu Fangyou 
Published: October 2024

Abstract

It’s urgently needed to find new repurposed antibacterial drugs as the desired novel choices to counter biofilms and persister of gram-positive bacteria. Several reports have supported that Fingolimod, which was approved by FDA as a novel drug for the treatment of relapsing multiple sclerosis, can kill the bacteria by selectively disrupting the cell membrane of bacteria. However, the action mode and mechanism of Fingolimod against gram-positive bacteria remains elusive. Our data indicated that Fingolimod exerted the bactericidal activity against a wide spectrum of gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, Streptococcus agalactiae et al. Moreover, Fingolimod could significantly eliminate the persister, inhibit biofilm formation, eradicate mature biofilm in vitro against S. aureus. Fingolimod rapidly eradicated S. aureus by pH-dependent disruption of the bacterial cell membrane's permeability and integrity, with its minimum inhibitory concentration (MIC) increasing up to 16-fold in response to elevated concentrations of phospholipids CL, PG, and PE. After four months of Fingolimod exposure, the MIC values of S. aureus showed a slight increase, and three genetic mutations related to phospholipid metabolism—PhoP, AcpP, and PhoU2—were identified in Fingolimod-induced clones, suggesting that Fingolimod may disrupt the cell membrane by targeting phospholipids. Overall, Fingolimod kills S. aureus by disrupting the bacteria membrane and targeting the phospholipids within the cell membrane. This study first reveals that Fingolimod kills S. aureus by targeting cell membrane phospholipids, a mechanism similar to cationic bactericides.