bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silver(I) Complexes of Diphenylpyridines: Crystal Structures, Luminescence Studies, Theoretical Insights, and Biological Activities
Authors: Wang De‐Hui , Zhang Yuan , Wang Yu‐Tong , Feng Hui‐Yan , Chen Yong , Zhao De‐Zhi 
Published: March 2017

AbstractA series of simple two‐coordinated cationic silver(I) complexes, namely, [Ag{4‐(4‐R1‐phenyl)‐2,6‐diphenylpyridine}2]X (X=ClO4−, BF4−, or SO3CF3−), with different electron‐donating or ‐withdrawing groups (e.g., R1=N(Me)2, Me, H, Cl, and Br) on the phenyl ring, were successfully prepared. Extensive characterization of these complexes by various NMR spectroscopy techniques and mass spectrometry was further corroborated by single‐crystal XRD analyses. Detailed photophysical investigations of [Ag{4‐(4‐N,N‐dimethylaminophenyl)‐2,6‐diphenylpyridine}2]ClO4 (C1) displayed a strong room‐temperature fluorescence in solution with an anomalously high luminescence quantum yield of 0.83. The effects of distinct substituent groups (C2–C5), π‐conjugated aromatic rings (C6 and C7), and anions (C8 and C9) on the photoluminescence properties were evaluated. Furthermore, DFT and time‐dependent DFT calculations were performed to discern the composition of the excited state, as well as to confirm the obtained relative emission energies upon substitution with electronically different ligands. These results indicated that the strong electron‐donating substituent of N,N‐dimethylamine played an important role in the unprecedented high luminescence quantum yield of C1. In addition, preliminary antimicrobial studies and confocal microscopy fluorescent imaging of HeLa cells labeled with these complexes reveal their potential applications in biological activities.
Characterization of Plant Small RNAs by Next Generation Sequencing
Authors: Mathioni Sandra M. , Kakrana Atul , Meyers Blake C. 
Published: March 2017

AbstractPlant small RNAs are ∼20 to 24 nucleotide noncoding RNAs that typically have repressive regulatory roles in gene expression, functioning at the transcriptional or post‐transcriptional level. This influence on regulation of developmental and physiological processes has direct effects on phenotype. High‐throughput sequencing technologies have enabled the sequencing of millions of small RNAs. Along with decreased sequencing costs, recent improvements in small RNA library construction have facilitated the ability to use minimal amounts of input RNA for analysis. This unit describes steps to isolate total RNA from limited amounts of plant tissue to construct small RNA libraries and perform small RNA data processing. © 2017 by John Wiley & Sons, Inc.
Lethal and behavioral impacts of diesel and fuel oil on the Antarctic amphipod Paramoera walkeri
Authors: Brown Kathryn E. , King Catherine K. , Harrison Peter L. 
Published: March 2017

Abstract

Toxicity testing with Antarctic species is required for risk assessment of fuel spills in Antarctic coastal waters. The lethal and sublethal (movement behavior) sensitivities of adults and juveniles of the Antarctic amphipod Paramoera walkeri to the water accommodated fractions (WAFs) of 3 fuels were estimated in extended-duration tests at –1 °C to 21 d. Response of P. walkeri for lethal hydrocarbon concentrations was slow, with 50% lethal concentrations (LC50s) first able to be estimated at 7 d for adults exposed to Special Antarctic Blend diesel (SAB), which had the highest hydrocarbon concentrations of the 3 fuel WAFs. Juveniles showed greater response to marine gas oil (MGO) and intermediate residual fuel oil (IFO 180) at longer exposure durations and were most sensitive at 21 d to IFO 180 (LC50 = 12 μg/L). Adults were initially more sensitive than juveniles; at 21 d, however, juveniles were more than twice as sensitive as adults to SAB (LC50 = 153 μg/L and 377 μg/L, respectively). Significant effects on movement behavior were evident at earlier time points and lower concentrations than was mortality in all 3 fuel WAFs, and juveniles were highly sensitive to sublethal effects of MGO. These first estimates of Antarctic amphipod sensitivity to diesel and fuel oils in seawater contribute to the development of ecologically relevant risk assessments for management of hydrocarbon contamination in the region. Environ Toxicol Chem 2017;36:2444–2455. © 2017 SETAC
Halogenated phenolic compounds in wild fish from Canadian Areas of Concern
Authors: Gilroy Ève A.M. , Muir Derek C.G. , McMaster Mark E. , Darling Colin , Campbell Linda M. , Alaee Mehran , Brown Scott B. , Sherry James P. 
Published: March 2017

Abstract

Concentrations of halogenated phenolic compounds were measured in the plasma of brown bullhead (Ameiurus nebulosus) from 4 Canadian Areas of Concern (AOCs), to assess exposure to suspected thyroid-disrupting chemicals. Hydroxylated polychlorinated biphenyls (OH-PCBs) were detected in every sample collected in 3 of the AOCs; the detection frequency was lower in samples from the Detroit River AOC. The OH-PCBs most frequently detected were pentachloro, hexachloro, and heptachloro congeners, which are structurally similar to thyroid hormones. Pentachlorophenol (PCP) was detected at highest concentrations (1.8 ng/g) in fish from Prince Edward Bay, the Bay of Quinte Lake reference site, and Hillman Marsh (the Wheatley Harbour reference site), suggesting local sources of contamination. Elevated PCP concentrations were also detected in the plasma of brown bullhead from exposed sites in the Toronto and Region AOC (0.4–0.6 ng/g). Triclosan was consistently detected in the Toronto and Region AOC (0.05–0.9 ng/g), consistent with wastewater emission. Greater concentrations were occasionally detected in the plasma of brown bullhead from the Bay of Quinte AOC. Concentrations of polybrominated diphenyl ethers were highest in the Toronto and Region AOC, and at 2 of the Bay of Quinte AOC exposed sites near Trenton and Belleville. Distribution patterns reflected the properties and usage of the compounds under investigation and the characteristics of each AOC. Environ Toxicol Chem 2017;36:2266–2273. © 2017 SETAC
Utility of the cumulative stress and mismatch hypotheses in understanding the neurobiological impacts of childhood abuse and recent stress in youth with emerging mental disorder
Authors: Paquola Casey , Bennett Maxwell R , Hatton Sean N , Hermens Daniel F. , Lagopoulos Jim 
Published: March 2017

AbstractChildhood abuse has an enduring impact on the brain's stress system. Whether the effects of childhood abuse and adulthood stress are additive (cumulative stress hypothesis) or interactive (mismatch hypothesis) is widely disputed, however. The primary aim of this study was to test the utility of the cumulative stress and mismatch hypotheses in understanding brain and behaviour. We recruited 64 individuals (aged 14–26) from a specialised clinic for assessment and early intervention of mental health problems in young people. A T1‐weighted MRI, a resting state fMRI and clinical assessment were acquired from each participant. Grey matter estimates and resting state functional connectivity (rsFC) of the hippocampus, amygdala and anterior cingulate cortex (ACC) were determined using segmentation and seed‐to‐voxel rsFC analyses. We explored the effects of childhood abuse and recent stress on the structure and function of the regions of interest within general linear models. Worse psychiatric symptoms were significantly related to higher levels of life time stress. Individuals with mismatched childhood and recent stress levels had reduced left hippocampal volume, reduced ACC‐ventrolateral prefrontal cortex rsFC and greater ACC‐hippocampus rsFC, compared to individuals with matched childhood and recent stress levels. These results show specific utility of the cumulative stress hypothesis in understanding psychiatric symptomatology and of the mismatch hypothesis in modelling hippocampal grey matter, prefrontal rsFC, and prefrontal‐hippocampal rsFC. We provide novel evidence for the enduring impact of childhood abuse on stress reactivity in a clinical population, and demonstrate the distinct effects of stress in different systems. Hum Brain Mapp 38:2709–2721, 2017. © 2017 Wiley Periodicals, Inc.
Using Reclaimed Water for Agricultural and Landscape Irrigation in China: a Review
Authors: Wang Zhen , Li Jiusheng , Li Yanfeng 
Published: March 2017

AbstractSuffering from severe water scarcity, China has been using wastewater for irrigating cereal, fiber, and vegetable crops as well as landscapes, for decades. During this time, both quantities and qualities have been enhanced from raw wastewater to secondary and even tertiary treated wastewater. Currently, approximately one‐third of the reclaimed water is used for agricultural irrigation. Moreover, 34, 12, 23 and 2% of the reclaimed water is used in the sector of recreation/environment, miscellaneous urban use, industry, and groundwater recharge, respectively. Extensive research has been conducted concerning irrigation with reclaimed water, including the responses of crops and risk assessments of the environment, soils, groundwater, and human exposure. A positive response to reclaimed water irrigation on crop growth and yield with acceptable product qualities was found as a resulted of exposure of the additional nutrient constituents of reclaimed water. These findings were generally supported, although reductions in crop yield and quality and the ornamental performance of landscapes and soil deterioration were occasionally reported in the literature. More reclaimed water is expected to be used for agricultural and landscape irrigation as the conventional water supply is becoming increasingly limited. The increasing concern of environmental risk caused by irrigation with reclaimed water and its complexity requires continuous monitoring and more research on the negative influences resulting from reclaimed water irrigation. Copyright © 2017 John Wiley & Sons, Ltd.
Insulin‐like growth factor‐1 (IGF‐1) enhances the osteogenic activity of bone morphogenetic protein‐6 (BMP‐6) in vitro and in vivo, and together have a stronger osteogenic effect than when IGF‐1 is combined with BMP‐2
Authors: Rico‐Llanos Gustavo A. , Becerra Jose , Visser Rick 
Published: March 2017

AbstractBone morphogenetic protein‐2 (BMP‐2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP‐2 treatments have several drawbacks and many groups are actively exploring alternatives. Since BMP‐6 has been demonstrated to be more osteoinductive, its use, either alone or together with other growth factors, might be an interesting option. In this work, we have compared the effect of BMP‐2, BMP‐6, or insulin‐like growth factor‐1 (IGF‐1), either alone or in combination. Murine preosteoblasts were treated with 15 nM IGF‐1 and/or 6 nM BMP‐2 or −6 and the expression of osteogenic marker genes, proliferation, and alkaline phosphatase (ALP) activity in vitro were analyzed. The results showed that IGF‐1 greatly enhanced the BMP‐induced osteogenic differentiation of these cells in general and that the ALP activity in the cultures was higher when the combination was made with BMP‐6 than with BMP‐2. Furthermore, we tested the osteogenic potential of these treatments in vivo by loading 25 pmoles of IGF‐1 and/or 10 pmoles of BMP‐2 or −6 onto absorbable collagen sponges and implanting them into an ectopic bone formation model in rats. This study revealed that only BMP‐6 was able to induce bone formation at the used dose and that the addition of IGF‐1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP‐6 with IGF‐1 might be a better alternative than BMP‐2 for orthopedic surgery or bone tissue engineering approaches. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1867–1875, 2017.
Impact of victimization, community climate, and community size on the mental health of sexual and gender minority youth
Authors: Paceley Megan S. , Goffnett Jacob , Gandy‐Guedes Megan 
Published: March 2017

AbstractSexual and gender minority (SGM) youth are at risk of stigma and victimization, which may lead to increased mental health symptoms, including depression, anxiety, and stress. The role of the community in exacerbating or mitigating the frequency of victimization and mental health symptoms among SGM youth has been understudied. Using a minority stress framework, this study examined the association between physical and nonphysical anti‐SGM victimization, perceived community climate, and community size and their effects on depression, anxiety, and stress among SGM youth. An online survey was completed by 296 SGM‐identified youth (aged 14–18 years). Results revealed that nonphysical forms of victimization were associated with depression, anxiety, and stress above and beyond physical victimization and community variables. Both types of victimization were more common in communities that participants perceived to be hostile and small towns. Practice implications include ways to reduce victimization and improve mental health via community climate and community interventions.
Late Holocene glacier reconstruction reveals retreat behind present limits and two‐stage Little Ice Age on subantarctic South Georgia
Authors: van der Bilt Willem G. M. , Bakke Jostein , Werner Johannes P. , Paasche Øyvind , Rosqvist Gunhild , Vatle Sunniva Solheim 
Published: March 2017

ABSTRACTObservational data show that climate in the Southern Ocean region is rapidly changing. However, past the instrumental period, our understanding of climate variability in the region is limited by a scarcity of high‐resolution palaeoclimate records. Alpine glaciers, present on many Southern Ocean islands, may provide such data because changes in their mass balance, extent and erosion rates often mark a response to climate shifts. Rock flour, the fine‐grained fraction of the glacial erosion process, is suspended in meltwater streams and transferred into the sediments of downstream lakes, continuously recording glacier variations. Here, we utilize this relationship to present a reconstruction of the Late Holocene glacier history of subantarctic South Georgia, using sediments from the glacier‐fed Middle Hamberg Lake. To fingerprint a glacial erosion/size signal, we used titanium counts, validated against changes in sediment density and grain size, allowing a continuous reconstruction of glacier variations over the past ∼1250 years. Together with local moraine evidence and supporting evidence from other Southern Hemisphere glaciers on New Zealand and in Patagonia, our findings reveal a series of consecutively diminishing Late Holocene advances. In addition to a glacier maximum before 1250 cal a BP, these include a two‐stage Litle Ice Age with advances around 300 and 120 cal a BP, in line with evidence from southern Patagonia. In addition, we present evidence for an unreported retreat behind present limits around 500 cal BP. Copyright © 2017 John Wiley & Sons, Ltd.
Cover Image, Volume 97, Issue 5
Authors: Wells Hannah C , Holmes Geoff , Jeng U‐Ser , Wu Wei‐Ru , Kirby Nigel , Hawley Adrian , Mudie Stephen , Haverkamp Richard G 
Published: March 2017

The cover image, by Hannah C Wells et al., is based on the Research Article A small angle X‐ray scattering study of the structure and development of looseness in bovine hides and leather, DOI: 10.1002/jsfa.7899.
image
Trend analysis of precipitation and drought in the Aegean region, Turkey
Authors: Güner Bacanli Ülker 
Published: March 2017

ABSTRACTTrend analysis of precipitation and drought will play a significant role in the future development and sustainable management of water resources. It is the main purpose of this paper to analyse meteorological droughts and trends. The variability of the standardized precipitation index (SPI) was investigated at 1, 3, 6, 9, 12 and 24 monthly intervals. The trends of 1, 3, 6, 9, 12 and 24 monthly SPI results were analysed by applying linear regression and the Mann–Kendall and Spearman's rho tests at the 5% significance level. The linear slopes of the trends were calculated with a technique proposed by Sen. Meteorological data from eight meteorological stations in the Aegean region of Turkey were used for the period 1960–2013.The monthly precipitation trend decreases in December, January, February and March in all regions according to the linear regression analysis results. Annual precipitation decreased at five stations. In drought analysis by the SPI, in a short time period (such as 3 months) drought is more frequent but shorter, and as the period increases the duration of drought also increases but frequency decreases. Winter droughts are beginning to occur in the class of ‘severe’ in recent years. In this study carried out for different time periods according to SPI values in all stations, the highest ranges are in the normal and mild drought degrees. In addition, severe and extreme droughts are also seen intensely frequently. Trend analysis of precipitation and drought is compared. The trend analyses of precipitation are in parallel with the results of drought analyses.
Genetic Characterization of a French Cohort of GNE‐mutation negative inclusion body myopathy patients with exome sequencing
Authors: Cerino Mathieu , Gorokhova Svetlana , Laforet Pascal , Ben Yaou Rabah , Salort‐Campana Emmanuelle , Pouget Jean , Attarian Shahram , Eymard Bruno , Deleuze Jean‐François , Boland Anne , Behin Anthony , Stojkovic Tanya , Bonne Gisele , Levy Nicolas , Bartoli Marc , Krahn Martin 
Published: March 2017

ABSTRACTIntroductionHereditary inclusion body myopathy (hIBM) refers to a group of clinically and genetically heterogeneous diseases. The overlapping histochemical features of hIBM with other genetic disorders lead to low diagnostic rates with targeted single‐gene sequencing. This is true for the most prevalent form of hIBM, GNEpathy. Therefore, we used whole‐exome sequencing (WES) to determine whether a cohort of clinically suspected GNEpathy patients undiagnosed by targeted GNE analysis could be genetically characterized.MethodsTwenty patients with hIBM but undiagnosed by targeted GNE sequencing were analyzed by WES before data filtering on 306 genes associated with neuromuscular disorders.ResultsSeven patients out of 20 were found to have disease‐causing mutations in genes associated with hIBM or genes allowing for hIBM in the differential diagnosis or associated with unexpected diagnosis.DiscussionNext‐generation sequencing is an efficient strategy in the context of hIBM, resulting in a molecular diagnosis for 35% of the patients initially undiagnosed by targeted GNE analysis. Muscle Nerve 56: 993–997, 2017
Event‐triggered UKF for nonlinear dynamic systems with packet dropout
Authors: Li Li , Yu Dongdong , Xia Yuanqing , Yang Hongjiu 
Published: March 2017

SummaryIn this paper, the event‐triggered nonlinear filtering problem is investigated for nonlinear dynamic systems over a wireless sensor network with packet dropout. Measurements are transmitted to a remote estimator only when a specific event happens for a reduction of communication cost. An event‐triggered unscented Kalman filter related to trigger threshold is derived. It is shown that the prediction error covariance of the proposed filter is bounded and converges to a steady value if the threshold and packet dropout rate are small enough. Sufficient conditions are obtained to ensure stochastic stability of the filter, where a critical value of the threshold exists. Two examples are given to illustrate the effectiveness of the proposed filter. Copyright © 2017 John Wiley & Sons, Ltd.
Towards More Efficient, Greener Syntheses through Flow Chemistry
Authors: Lummiss Justin A.M. , Morse Peter D. , Beingessner Rachel L. , Jamison Timothy F. 
Published: March 2017

AbstractTechnological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal, photochemical, catalytic, and biphasic chemical transformations examined by our group. Each of these demonstrate how the merits of a continuous flow synthesis platform can align with some of the goals put forth by the Twelve Principles of Green Chemistry. In particular, we illustrate the potential for improved reaction efficiency in terms of atom economy, product yield and reaction rates, the ability to design synthetic process with chemical and solvent waste reduction in mind as well as highlight the benefits of the real‐time monitoring capabilities in flow for highly controlled synthetic output.
Significance of Simultaneous Splenic Artery Resection in Left‐Sided Portal Hypertension After Pancreaticoduodenectomy with Combined Portal Vein Resection
Authors: Gyoten Kazuyuki , Mizuno Shugo , Nagata Motonori , Ogura Toru , Usui Masanobu , Isaji Shuji 
Published: March 2017

AbstractBackgroundIn pancreaticoduodenectomy (PD) with resection of portal vein (PV)/superior mesenteric vein (SMV) confluence, the splenic vein (SV) division may cause left‐sided portal hypertension (LPH).MethodsThe 88 pancreatic ductal adenocarcinoma patients who underwent PD with PV/SMV resection after chemoradiotherapy were classified into three groups: both SV and splenic artery (SA) were preserved in Group A (n = 16), SV was divided and SA was preserved in Group B (n = 58), and both SV and SA were divided in Group C (n = 14). We evaluated the influence of resection of SV and/or SA on LPH after PD with resection of PV/SMV confluence.ResultsThe incidence of postoperative varices in Groups A, B and C was 6.3, 67.2 and 38.5%, respectively (p < 0.001), and variceal bleeding occurred only in Group B (n = 4: 6.8%). In multivariate analysis, Group B was the only significant risk factor for the development of postoperative varices (Groups B vs. A: odds ratio = 39.6, p = 0.001, Groups C vs. A: odds ratio = 8.75, p = 0.066). The platelet count ratio at 6 months after operation comparing to preoperative value was 0.93, 0.73 and 1.09 in Groups A, B and C, respectively (Groups B vs. C: p < 0.05), and spleen volume ratio at 6 months was 1.00, 1.37 and 0.96 in Groups A, B and C, respectively (Groups B vs. A and C: p < 0.01 and p < 0.05).ConclusionIn PD with resection of PV–SMV confluence, the SV division causes LPH, but the concomitant division of SV and SA may attenuate it.