bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics analysis of baseline computed tomography to predict oncological outcomes in patients treated for resectable colorectal cancer liver metastasis
Authors: Montagnon Emmanuel , Cerny Milena , Hamilton Vincent , Derennes Thomas , Ilinca André , Elforaici Mohamed El Amine , Jabbour Gilbert , Rafie Edmond , Wu Anni , Perdigon Romero Francisco , Cadrin-Chênevert Alexandre , Kadoury Samuel , Turcotte Simon , Tang An 
Published: September 2024

Objective
The purpose of this study was to determine and compare the performance of pre-treatment clinical risk score (CRS), radiomics models based on computed (CT), and their combination for predicting time to recurrence (TTR) and disease-specific survival (DSS) in patients with colorectal cancer liver metastases.

Methods
We retrospectively analyzed a prospectively maintained registry of 241 patients treated with systemic chemotherapy and surgery for colorectal cancer liver metastases. Radiomics features were extracted from baseline, pre-treatment, contrast-enhanced CT images. Multiple aggregation strategies were investigated for cases with multiple metastases. Radiomics signatures were derived using feature selection methods. Random survival forests (RSF) and neural network survival models (DeepSurv) based on radiomics features, alone or combined with CRS, were developed to predict TTR and DSS. Leveraging survival models predictions, classification models were trained to predict TTR within 18 months and DSS within 3 years. Classification performance was assessed with area under the receiver operating characteristic curve (AUC) on the test set.

Results
For TTR prediction, the concordance index (95% confidence interval) was 0.57 (0.57–0.57) for CRS, 0.61 (0.60–0.61) for RSF in combination with CRS, and 0.70 (0.68–0.73) for DeepSurv in combination with CRS. For DSS prediction, the concordance index was 0.59 (0.59–0.59) for CRS, 0.57 (0.56–0.57) for RSF in combination with CRS, and 0.60 (0.58–0.61) for DeepSurv in combination with CRS. For TTR classification, the AUC was 0.33 (0.33–0.33) for CRS, 0.77 (0.75–0.78) for radiomics signature alone, and 0.58 (0.57–0.59) for DeepSurv score alone. For DSS classification, the AUC was 0.61 (0.61–0.61) for CRS, 0.57 (0.56–0.57) for radiomics signature, and 0.75 (0.74–0.76) for DeepSurv score alone.

Conclusion
Radiomics-based survival models outperformed CRS for TTR prediction. More accurate, noninvasive, and early prediction of patient outcome may help reduce exposure to ineffective yet toxic chemotherapy or high-risk major hepatectomies.
Internet use and adolescent development in rural China: A scoping review protocol of research landscape and gaps
Authors: Zhang Linxiao 
Published: September 2024

Introduction
In the digital era, the Internet has become a necessity in adolescents’ daily lives. Many studies globally are exploring the influences of Internet use on adolescent development, but they focus on the negative impacts of simplistic “screen time” on adolescents’ physical and mental health, rather than both positive and negative influences of multifaceted Internet use on multidimensional adolescent development. Specifically in rural China, adolescents live in disadvantageous and marginalizing contexts, and Internet use is widespread among this population. However, knowledge on Internet use and adolescent development in rural China is fragmented. It is still unclear in what ways Internet use would bring benefits or risks for Chinese rural adolescents’ healthy growth. Therefore, the objective of this scoping review is to identify the current research landscape, gaps, and future directions in rural China contexts. It aims to provide a comprehensive overview of elements, findings, and limitations in existing empirical studies on the influences of Internet use on adolescent development in rural China.

Materials and methods
The standard for conducting this scoping review is the five-stage model proposed by Arksey and O’Malley, and the reporting standard is the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: Extension for Scoping Reviews (PRISMA-ScR). The overall research question is: What are the influences of Internet use on adolescent development in rural China? In consultation with librarians, to locate articles, subject headings (controlled vocabularies) and textwords (keywords) in article titles, abstracts, and author-assigned keywords will be searched in APA PsycInfo (psychology), China National Knowledge Infrastructure (interdisciplinary), Communication Abstracts (media and communication), Education Source (education), MEDLINE (public health), Social Services Abstracts (social work), Social Work Abstracts (social work), and Sociological Abstracts (sociology). The review process via Covidence will consist of two sequential steps based on inclusion/exclusion criteria: the title and abstract review and the full-text review. Then study characteristics and research findings will be charted, and the results will be analyzed and synthesized quantitatively and qualitatively via visualizations and narratives, guided by the typological frameworks of Internet use and adolescent development.

Discussion
The scoping review will be a pioneering review to inform the current research landscape and gaps in the Internet use influences on adolescent development in rural China. It will advance the research agenda on this issue conceptually, theoretically, and empirically. In addition, it can provide contextual implications for designing prevention and intervention programs.
Quality of life of elementary school students with sleep-disordered breathing and allergic rhinitis: A population-based study in Thailand
Authors: Sritipsukho Paskorn , Chaiyakulsil Chanapai , Junsawat Pimchanok 
Published: September 2024

Background
Sleep-disordered breathing (SDB) and allergic rhinitis (AR) are common problems that can lead to worsening quality of life (QOL) in children with these conditions. There is scarce evidence on the QOL of children with SDB outside of the hospital setting with inconsistent evidence on the association of AR and QOL concerning the SDB in children. Thus, the primary objective of this study is to determine the QOL concerning the SDB of elementary school students by using OSA-18. We also aim to provide the relationship of allergic rhinitis to the QOL.

Methods
A cross-sectional study was conducted on all elementary school students, aged 6–12 years, from 10 elementary schools. The QOL of all participants was evaluated by the Thai version of the caregiver-administered OSA-18 questionnaire. The simple and multiple linear regression models were used to determine the effect of allergic rhinitis on the OSA-18 total scores.

Results
A total of 3,053 children were included in the final analysis, 50.1% male. At least a moderate impact on QOL from SDB was observed in 9.4% of the population. Children with AR had significantly higher mean total OSA– 18 scores than the children without AR (47.5 ± 15.0 VS 38.5 ± 13.1, p < 0.001). After the adjustment for age, gender, body mass index, household income, and history of asthma, the point estimate of the adjusted beta regression coefficient on the OSA-18 total score in children with AR was 7.82 (95% CI: 6.00–9.65, p < 0.001). Significant associations were observed between AR and all domains except for emotional distress.

Conclusions
A substantial number of elementary school children had at least a moderate impact on the QOL from SDB, especially those with AR. Thus, effective screening of SDB in children with AR should be done to improve the QOL of these children.
Fashion-ology: Fashion Studies in the Postmodern Digital Era, Yuniya Kawamura (2023)
Authors: Weiss Catharine 
Published: September 2024

Review of: Fashion-ology: Fashion Studies in the Postmodern Digital Era, Yuniya Kawamura (2023)
London: Bloomsbury Publishing, 182 pp.,
ISBN 978-1-35033-186-0, p/bk, $29.95
Ducks: Two Years in the Oil Sands, Kate Beaton (2022)
Authors: Unrau Melanie Dennis 
Published: September 2024

Review of: Ducks: Two Years in the Oil Sands, Kate Beaton (2022)
Montreal: Drawn & Quarterly, 436 pp.,
ISBN 978-1-77046-289-2, h/bk, $39.95

Crude: A Memoir, Pablo Fajardo, Sophie Tardy-Joubert and Damien Roudeau (2021)
University Park, PA: Graphic Mundi, 127 pp.,
ISBN 978-0-27108-806-8, h/bk, USD 19.95
Manual therapy plus sexual advice compared with manual therapy or exercise therapy alone for lumbar radiculopathy: a randomized controlled trial
Authors: Danazumi Musa Sani , Adamu Isa Abubakar , Usman Musbahu Hamisu , Yakasai Abdulsalam Mohammed 
Published: September 2024

Abstract

Context
The biopsychosocial approach to managing low back pain (LBP) has the potential to improve the quality of care for patients. However, LBP trials that have utilized the biopsychosocial approach to treatment have largely neglected sexual activity, which is an important social component of individuals with LBP.

Objectives
The objectives of the study are to determine the effects of manual therapy plus sexual advice (MT+SA) compared with manual therapy (MT) or exercise therapy (ET) alone in the management of individuals with lumbar disc herniation with radiculopathy (DHR) and to determine the best sexual positions for these individuals.

Methods
This was a single-blind randomized controlled trial. Fifty-four participants diagnosed as having chronic DHR (>3 months) were randomly allocated into three groups with 18 participants each in the MT+SA, MT and ET groups. The participants in the MT+SA group received manual therapy (including Dowling’s progressive inhibition of neuromuscular structures and Mulligan’s spinal mobilization with leg movement) plus sexual advice, those in the MT group received manual therapy only and those in the ET group received exercise therapy only. Each group received treatment for 12 weeks and then followed up for additional 40 weeks. The primary outcomes were pain, activity limitation, sexual disability and kinesiophobia at 12 weeks post-randomization.

Results
The MT+SA group improved significantly better than the MT or ET group in all outcomes (except for nerve function), and at all timelines (6, 12, 26, and 52 weeks post-randomization). These improvements were also clinically meaningful for back pain, leg pain, medication intake, and functional mobility at 6 and 12 weeks post-randomization and for sexual disability, activity limitation, pain catastrophizing, and kinesiophobia at 6, 12, 26, and 52 weeks post-randomization (p<0.05). On the other hand, many preferred sexual positions for individuals with DHR emerged, with “side-lying” being the most practiced sexual position and “standing” being the least practiced sexual position by females. While “lying supine” was the most practiced sexual position and “sitting on a chair” was the least practiced sexual position by males.

Conclusions
This study found that individuals with DHR demonstrated better improvements in all outcomes when treated with MT+SA than when treated with MT or ET alone. These improvements were also clinically meaningful for sexual disability, activity limitation, pain catastrophizing, and kinesiophobia at long-term follow-up. There is also no one-size-fits-all to sexual positioning for individuals with DHR.
Differential object marking in Western Malayo-Polynesian symmetrical voice languages
Authors: Bonmann Svenja , Riesberg Sonja , Himmelmann Nikolaus P. 
Published: September 2024

AbstractDifferential object marking (DOM) is known from a great variety of language families. We present data suggesting that, contrary to what is suggested in recent typological surveys, DOM is also a widespread phenomenon in Austronesian symmetrical voice languages. To do this, we show why the identification of DOM constructions in these languages is difficult, propose a definition for DOM that takes note of the peculiarities of symmetrical voice systems, and briefly review three types of DOM systems attested in the area. Our findings have implications for claims regarding the universality of DOM, and quality control in compiling large-scale typological databases.
Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
Authors: Liu Tao , Zheng Fenshuang , Liu Lin , Zhou Hua , Shen Tao , Li Yanping , Zhang Wei 
Published: September 2024

Abstract

Background
Paraquat (PQ) is a frequently used herbicide with neurotoxic effects after acute or chronic exposure. Although in vitro evidence supports the PQ toxicity to dopamine cells, its in vivo effects (especially the chronic exposure) remain ambiguous. In this study, we investigated the effect of chronic PQ exposure on the blood–brain barrier (BBB) damage and the underlying mechanisms.

Methods
Adult male Sprague Dawley rats and primary human brain microvascular endothelial (PHBME) cells were exposed to PQ as the animal and cell models. Evans Blue staining and hematoxylin & eosin staining were conducted to examine the BBB and brain tissue damages. The inflammatory cytokines were quantified via enzyme linked immunosorbent assay. The changes of PI3K/AKT signaling pathway were detected by western blot.

Results
PQ exposure can cause significant pathological lesions in the brain tissues and the BBB. IL-6 and reactive oxygen species levels were found to be significantly upregulated after PQ exposure in both the animal and cell models. PQ treatment could arrest the cell proliferation and migration in PHBME cells. PQ treatment promoted the phosphorylation of PI3K and AKT, and the application of PI3K inhibitor could attenuate PQ-induced IL-6 production, oxidative stress, BBB disruption, and brain tissue damage.

Conclusion
Our study demonstrated that chronic PQ exposure could impair the BBB function and induce brain tissue damage. The overactivation of the PI3K/AKT pathway, consequent upregulation of IL-6 production, and increased oxidative stress appear to mediate the inflammatory damage resulting from PQ exposure.
INDIGENOUS POPULATION IN THE VIEWS OF THE YAKUT REGIONAL HEAD (1820S-1830S)
Authors: ВАСИЛЬЕВ А.Д. 
Published: September 2024

Статья посвящена репрезентации коренного населения Якутской области - якутов, тунгусов, ламутов и др. - в ежегодных отчетах якутского областного начальника Н.И. Мягкова. В его отчетах большое внимание уделялось решению земельного вопроса, а также негативному влиянию на жизнь аборигенов ряда земских чиновников, казаков, духовенства и торговцев. Инородческое население в отчетах освещалось с позиций патернализма и позиционировалось как объект заботы и защиты со стороны областной администрации. Сконструирован образ «образованного инородца», способного к организации самоуправления. Прослеживается общеимперская тенденция, характерная для первой половины XIX в., связанная с высокой степенью этнической толерантности в административной политике самодержавия в контексте процесса инкорпорации региона в российское пространство.
The article examines the representation of the indigenous population of the Yakut region in the 1820s-1830s - the Yakuts, Tungus, Lamuts, etc., based on the content of the annual reports of the regional head Nikolai Ivanovich Myagkov, stored in the fonds of the Russian State Historical Archive (St. Petersburg), which the official provided to the Minister of Internal Affairs. The principle of historicism formed the methodological basis of the study. The article deals with the problems of “vagrant” and “nomadic” foreigners, it is noted that particular attention in the reports was given to the latter, the Yakuts, who constituted the main indigenous population in terms of their numbers in the Yakut region. The reports focused on the “land issue” associated with the shortage and non-equal distribution of mowing areas for the Yakuts; the problems of delimiting hunting areas between the Yakuts and Tungus. In addition, the issues of the negative impact of some categories of the population on the life of the aborigines were raised, primarily zemstvo officials, and then the Cossacks, the clergy and merchants; the fight against arbitrariness and the restriction of communications were proposed as a solution to the problem. The reports presented the indigenous population in a spirit of paternalism and positioned it as an object of care and protection by the regional administration. The image of an “educated foreigner” was created, capable of organizing self-government, in particular, the Yakut Steppe Duma, established on the basis of the Statute of Alien Administration of 1822; such qualities as laziness or mental retardation were not characteristic of the aboriginal population of the Yakut region, and among the negative qualities only “snitching” was noted. The content of the annual reports reveals a trend characteristic of the first half of the 19th century, associated with a high degree of ethnic tolerance in the administrative policy of autocracy in the context of the process of incorporation of the region into the all-Russian space, as well as the absence of Russification elements.
Pre- and Post-admission Care for Children Hospitalized With Skin and Soft Tissue Infections
Authors: Rickey Lisa , Hall Matt , Berry Jay G. 
Published: September 2024

BACKGROUND AND OBJECTIVES
Although skin and soft tissue infections (SSTIs) are among the most common indications for pediatric hospitalization, little is known about outpatient care received for SSTI before and after hospitalization. We assessed peri-hospitalization care for SSTI, including antibiotic exposures and their impact on hospital length of stay (LOS).

METHODS
This is a retrospective cohort study of 1229 SSTI hospitalizations in 2019 from children aged 1-to-18 years enrolled in Medicaid from 10 US states included in the Merative Marketscan Medicaid database. We characterized health service utilization (outpatient visits, laboratory and diagnostic tests, antibiotic exposures) 14 days before and 30 days after hospitalization and evaluated the effects of pre-hospitalization care on hospital LOS with linear regression.

RESULTS
Only 43.1% of children hospitalized with SSTI had a preceding outpatient visit with a SSTI diagnosis, 69.8% of which also filled prescription for an antibiotic. Median LOS for SSTI admission was 2 days (interquartile range 1–3). Pre-hospitalization visits with a diagnosis of SSTI were associated with a 0.7 day reduction (95% confidence interval: 0.6–0.81) in LOS (P &lt; .001), but pre-hospital antibiotic exposure alone had no effect on LOS. Most children (81.7%) filled antibiotic prescriptions after hospital discharge and 74.5% had post-discharge ambulatory visits.

CONCLUSIONS
Although most children did not receive pre-admission care for SSTI, those that did had a shorter hospitalization. Further investigation is necessary on how to optimize access and use of outpatient care for SSTI.
Rendimiento diagnóstico de los antígenos de <i>Leishmania braziliensis</i> y <i>Leishmania peruviana</i> en el método de inmunoblot para la detección de la leishmaniasis tegumentaria americana
Authors: Rojas-Palomino Nyshon , Sandoval-Juarez Aidé , Solis-Sánchez Gilmer , Minaya-Gómez Gloria 
Published: September 2024

El presente estudio se planteó determinar el rendimiento de antígenos de Leishmania braziliensis y Leishmania peruviana en la detección de LTA, fue desarrollado a partir de muestras de suero obtenidas entre 2013 - 2016. Los antígenos solubles y de excreción/secreción obtenidos fueron transferidos a membrana de nitrocelulosa mediante un ensayo de inmunotransferencia. Se realizó la evaluación frente a sueros confirmados para LTA, a un nivel de confianza al 95%, logrando determinar que, el antígeno soluble de Leishmania braziliensis presenta una sensibilidad del 87,7%, especificidad del 100% y área bajo la curva de 0,95; mientras que, Leishmania peruviana se encontró valores de 92,3%, 95,7% y 0,94 respectivamente. De acuerdo a los resultados, recomendamos realizar lacaracterización y análisis de las regiones inmunogénicas reportadas a fin de continuar con el desarrollo de proteínas recombinantes y sintéticas, orientadas a mejorar la eficiencia del diagnóstico serológico de la enfermedad.
Mechanical ventilation, hospitalization time, deaths and disability according to the variants of Guillain-Barré syndrome: systematic review and meta-analysis
Authors: Castro Diaz Silvana Ximena , Pereira-Salto Luiza , Araujo Castillo Roger Vladimir 
Published: September 2024

Objectives. To determine the requirement and time to mechanical ventilation and Intensive Care Unit (ICU), hospitalization and hospitalization time, death and disability of the axonal variants of Guillain-Barré Syndrome (GBS) in comparison with the acute demyelinating variant in patients of all the ages. Materials and methods. The systematic review that included patients with GBS. The exposure variable was the axonal variants and the comparator was acute inflammatory demyelinating polyneuropathy (AIDP). The outcomes were the requirement and time on mechanical ventilation (MV), requirement and time in the ICU, hospitalization time, disability and death. The NewCasttle-Ottawa Scale (NOS) was used to assess risk of bias. A meta-analysis was conducted to calculate mean differences and relative risks (RR) with their 95% confidence intervals (CI) using inverse variances and random effects models. Results. Of the 3116 articles found, 46 met the selection criteria. The time on MV was 7.42 days (95% CI: 0.36 to 1.48) and the hospitalization time was 3.11 (95% CI: 0.73 to 5.49) days for the axonal variants. The axonal variants had a RR of 0.47 (95% CI: 0.24 to 0.92) for the requirement of MV in adults, but it was 1.68 (95% CI: 1.25 to 2.25) in children. There was a high statistical heterogeneity. Conclusions. Axonal variants showed, on average, longer MV and hospitalization time, overall and by subgroups. A high MV requirement was found for axonal variants in children; it was lower for adults.
Características del síndrome inflamatorio multisistémico asociado a COVID-19 en niños atendidos en un hospital peruano, 2020-2022
Authors: Atamari-Anahui Noé , Huby-Muñoz Cynthia , Peña-Coello Claudia , Guillen-Buleje Deli , Gomez-Martinez Luis , Nuñez-Paucar Héctor , Zamudio-Aquise Mariela , Bernal-Mancilla Raúl , De Coll-Vela Liz , Orellana-Siuce Carlos , Candela-Herrera Jorge 
Published: September 2024

El propósito del estudio fue describir las características del síndrome inflamatorio multisistémico asociado a COVID-19 (SIM-C) en los primeros tres años de pandemia en niños de un hospital pediátrico del Perú. Se realizó un estudio observacional, descriptivo con datos de 73 pacientes y se describieron las características clínicas, laboratoriales, tratamiento y complicaciones según la ola de la pandemia y si tuvieron shock. La mediana de edad fue 6 años, las manifestaciones gastrointestinales y mucocutáneas fueron frecuentes en las tres olas. El fenotipo similar a enfermedad de Kawasaki se presentó en 34 (46,6%) pacientes y 21 (28,8%) pacientes desarrollaron shock. El tratamiento más usado fue la inmunoglobulina (95,9%), ácido acetil salicílico (94,5%) y corticoide (86,3%). Cinco (7%) pacientes tuvieron aneurisma coronario y 17 (23,3%) ingresaron a la unidad de cuidados intensivos (UCI). Los pacientes con shock tuvieron mayor alteración laboratorial y necesidad de ventilación mecánica. En conclusión, el SIM-C ha disminuido en los primeros tres años de pandemia posiblemente por la vacunación de COVID-19 en niños.