bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer
Authors: Gautam Jaya , Ku Jin-Mo , Regmi Sushil Chandra , Jeong Hyunyoung , Wang Ying , Banskota Suhrid , Park Myo-Hyeon , Nam Tae-gyu , Jeong Byeong-Seon , Kim Jung-Ae 
Published: May 2017

Abstract
NADPH oxidase–derived reactive oxygen species (ROS) potentiate receptor tyrosine kinase (RTK) signaling, resulting in enhanced angiogenesis and tumor growth. In this study, we report that BJ-1301, a hybrid of pyridinol and alpha-tocopherol, exerts anticancer effects by dual inhibition of NADPH oxidase and RTK activities in endothelial and lung cancer cells. BJ-1301 suppresses ROS production by blocking translocation of NADPH oxidase cytosolic subunits to the cell membrane, thereby inhibiting activation. The potency of RTK inhibition by BJ-1301 was lower than that of sunitinib (a multi-RTK inhibitor), but the inhibition of downstream signaling pathways (e.g., ROS generation) and subsequent biological changes (e.g., NOX2 induction) by BJ-1301 was superior. Consistently, BJ-1301 inhibited cisplatin-resistant lung cancer cell proliferation more than sunitinib did. In xenograft chick or mouse tumor models, BJ-1301 inhibited lung tumor growth, to an extent greater than that of sunitinib or cisplatin. Treatments with BJ-1301 induced regression of tumor growth, potentially due to downregulation of autocrine-stimulatory ligands for RTKs, such as TGFα and stem cell factor, in tumor tissues. Taken together, the current study demonstrates that BJ-1301 is a promising anticancer drug for the treatment of lung cancer. Mol Cancer Ther; 16(10); 2144–56. ©2017 AACR.
Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP
Authors: Sarkar Sukumar , Brautigan David L. , Larner James M. 
Published: May 2017

Abstract
Reducing the levels of the androgen receptor (AR) is one of the most viable approaches to combat castration-resistant prostate cancer. Previously, we observed that proteasomal-dependent degradation of AR in response to 2-methoxyestradiol (2-ME) depends primarily on the E3 ligase C-terminus of HSP70-interacting protein (STUB1/CHIP). Here, 2-ME stimulation activates CHIP by phosphorylation via Aurora kinase A (AURKA). Aurora A kinase inhibitors and RNAi knockdown of Aurora A transcript selectively blocked CHIP phosphorylation and AR degradation. Aurora A kinase is activated by 2-ME in the S-phase as well as during mitosis, and phosphorylates CHIP at S273. Prostate cancer cells expressing an S273A mutant of CHIP have attenuated AR degradation upon 2-ME treatment compared with cells expressing wild-type CHIP, supporting the idea that CHIP phosphorylation by Aurora A activates its E3 ligase activity for the AR. These results reveal a novel 2-ME→Aurora A→CHIP→AR pathway that promotes AR degradation via the proteasome that may offer novel therapeutic opportunities for prostate cancer. Mol Cancer Res; 15(8); 1063–72. ©2017 AACR.
Artificial Neural Network for Non-Intrusive Electrical Energy Monitoring System
Authors: Khazin Kaman Khairell , Faramarzi Mahdi , Ibrahim Sallehuddin , Amri Md Yunus Mohd 
Published: May 2017

<p> This paper discusses non-intrusive electrical energy monitoring (NIEM) system in an effort to minimize electrical energy wastages. To realize the system, an energy meter is used to measure the electrical consumption by electrical appliances. The obtained data were analyzed using a method called multilayer perceptron (MLP) technique of artificial neural network (ANN). The event detection was implemented to identify the type of loads and the power consumption of the load which were identified as fan and lamp. The switching ON and OFF output events of the loads were inputted to MLP in order to test the capability of MLP in classifying the type of loads. The data were divided to 70% for training, 15% for testing, and 15% for validation. The output of the MLP is either ‘1’ for fan or ‘0’ for lamp. In conclusion, MLP with five hidden neurons results obtained the lowest average training time with 2.699 seconds, a small number of epochs with 62 iterations, a min square error of 7.3872×10-5, and a high regression coefficient of 0.99050.</p>
A New Methodology of Hierarchical Image Fusion in Framework for Hyperspectral Image Segmentation
Authors: Raviteja B. , Surendra Prasad Babu M. , Venkata Rao K. , Harikiran Jonnadula 
Published: May 2017

<p>Hyperspectral imaging system contains stack of images collected from the sensor with different wavelengths representing the same scene on the earth. This paper presents a framework for hyperspectral image segmentation using a clustering algorithm. The framework consists of four stages in segmenting a hyperspectral data set. In the first stage, filtering is done to remove noise in image bands. Second stage consists of dimensionality reduction algorithms, in which the bands that convey less information or redundant data will be removed. In the third stage, the informative bands which are selected in the second stage are merged into a single image using hierarchical fusion technique. In the hierarchical image fusion, the images are grouped such that each group has equal number of images. This methodology leads to group of images having much varied information, thus decreasing the quality of fused image. This paper presents a new methodology of hierarchical image fusion in which similarity metrics are used to create image groups for merging the selected image bands. This single image is segmented using Fuzzy c-means clustering algorithm. The experimental results show that this framework will segment the data set more accurately by combining all the features in the image bands. </p>
Molecular and clinical profile of VWD in a large cohort of Chinese population: application of next generation sequencing and CNVplex® technique
Authors: Liang Qian , Qin Huanhuan , Ding Qiulan , Xie Xiaoling , Wu Runhui , Wang Hongli , Hu Yiqun , Wang Xuefeng 
Published: May 2017

SummaryVon Willebrand disease (VWD), the most common inherited bleeding disorder, is characterised by a variable bleeding tendency, heterogeneous laboratory phenotype and race specific distribution of mutations. The present study aimed to determine the correlation of genotype and phenotype in 200 Chinese individuals from 90 unrelated families with VWD. Next generation sequencing (NGS) of the whole coding VWF, copy number analysis of VWF by CNVplex® technique as well as a comprehensive phenotypic assessment were carried out in all index patients (IPs). We identified putative mutations in all IPs except five mild type 1 (85/90, 94.4%). In total, 98 different mutations were detected, 62 (63.3% of which were reported for the first time (23 missense mutations, 1 regulatory mutation, 12 splice site mutations and 26 null mutations). Mutations p.Ser1506Leu and p.Arg1374His/Cys/ Ser were the most frequent mutations in 2A (33% of cases) and 2M VWD (67% of cases), respectively. In addition, mutation p.Arg816Trp was detected repeatedly in type 2N patients, while mutation p.Arg854Gln, extremely common in Caucasians, was not found in our cohort. Thirty-three patients had two or more putative mutations. Unlike most cases of type 1 and type 2 VWD, which were transmitted dominantly, we presented seven severe type 1, two type 2A and one type 2M with autosomal recessive inheritance. Here the phenotypic data of patients with novel mutations will certainly contribute to the better understanding of the molecular genetics of VWF-related phenotypes.Supplementary Material to this article is available online at www.thrombosis-online.com.
Predicting Domain-Specific Health-Related Quality of Life Using Acute Infarct Volume
Authors: Lin Chen , Lee Jungwha , Chatterjee Neil , Corado Carlos , Carroll Timothy , Naidech Andrew , Prabhakaran Shyam 
Published: May 2017

Background and Purpose—
Limited data exist on the relationship between acute infarct volume and health-related quality of life (HRQOL) measures after ischemic stroke. We evaluated whether acute infarct volume predicts domain-specific Neuro-Quality of Life scores at 3 months after stroke.

Methods—

Between 2012 and 2014, we prospectively enrolled consecutive patients with ischemic stroke and calculated infarct volume. Outcome scores at 3 months included modified Rankin Scale and Neuro-Quality of Life
T
scores. We evaluated whether volume organized by quartiles predicted modified Rankin Scale and HRQOL scores at 3 months using logistic and linear regression as appropriate, adjusting for relevant covariates. We calculated variance accounted for (
R
2
) overall and by volume for each domain of HRQOL.

Results—

Among 490 patients (mean age 64.2±15.86 years; 51.2% male; 63.3% White) included for analysis, 58 (11.8%) were disabled (modified Rankin Scale score of >2) at 3 months. In unadjusted analysis, the highest volume quartile remained a significant predictor of 1 HRQOL domain, applied cognition–general concerns (
R
2
=0.06;
P
<0.001). Our fully adjusted prediction model explained 32% to 51% of the variance in HRQOL: upper extremity (
R
2
=0.32), lower extremity (
R
2
=0.51), executive function (
R
2
=0.45), and general concerns (
R
2
=0.34).

Conclusions—
Acute infarct volume is a poor predictor of HRQOL domains after ischemic stroke, with the exception of the cognitive domain. Overall, clinical and imaging variables explained <50% of the variance in HRQOL outcomes at 3 months. Our data imply that a broad range of factors, some known and others undiscovered, may better predict poststroke HRQOL than what is currently available.
Door-to-Needle Delays in Minor Stroke
Authors: Rostanski Sara K. , Shahn Zachary , Elkind Mitchell S.V. , Liberman Ava L. , Marshall Randolph S. , Stillman Joshua I. , Williams Olajide , Willey Joshua Z. 
Published: May 2017

Background and Purpose—
Thrombolysis rates among minor stroke (MS) patients are increasing because of increased recognition of disability in this group and guideline changes regarding treatment indications. We examined the association of delays in door-to-needle (DTN) time with stroke severity.

Methods—
We performed a retrospective analysis of all stroke patients who received intravenous tissue-type plasminogen activator in our emergency department between July 1, 2011, and February 29, 2016. Baseline characteristics and DTN were compared between MS (National Institutes of Health Stroke Scale score ≤5) and nonminor strokes (National Institutes of Health Stroke Scale score >5). We applied causal inference methodology to estimate the magnitude and mechanisms of the causal effect of stroke severity on DTN.

Results—

Of 315 patients, 133 patients (42.2%) had National Institutes of Health Stroke Scale score ≤5. Median DTN was longer in MS than nonminor strokes (58 versus 53 minutes;
P
=0.01); fewer MS patients had DTN ≤45 minutes (19.5% versus 32.4%;
P
=0.01). MS patients were less likely to use emergency medical services (EMS; 62.6% versus 89.6%,
P
<0.01) and to receive EMS prenotification (43.9% versus 72.4%;
P
<0.01). Causal analyses estimated MS increased average DTN by 6 minutes, partly through mode of arrival. EMS prenotification decreased average DTN by 10 minutes in MS patients.

Conclusions—
MS had longer DTN times, an effect partly explained by patterns of EMS prenotification. Interventions to improve EMS recognition of MS may accelerate care.
“In My Modest Cell I am Not a Rebel”
Authors: Berlis Angela 
Published: May 2017

The contribution explores the question of how people react to situations and experiences of transition and radical change which have a major impact on their own lives. What kind of mindset do they develop in the process, who are their role models and how do they overcome spiritual hardship and marginalisation? The life and work of Charlotte Lady Blennerhassett, née Countess Leyden (1843–1917), serves as a case-study showing how learned liberal Catholics – in this case a lay noblewoman – dealt with their spiritual homelessness in the post-1870 ultramontanised Roman Catholic Church. Blennerhassett’s historical biographies reveal an interest in people in situations of threshold and transition. Through her writings on historical and cultural issues, Blennerhassett addressed topics as freedom, reconciliation of peoples and nations and ethical action. For her, the role of religion in this context was evident. The writings of Charlotte Blennerhassett, “the last European” (as she was described in obituaries), contributed to saving the non-ultramontane heritage from oblivion.
Comparison of Raindrop Size Distributions in a Midlatitude Continental Squall Line during Different Stages as Measured by Parsivel over East China
Authors: Zhang Hongsheng , Zhang Yun , He Hongrang , Xie Yanqiong , Zeng Qingwei 
Published: May 2017

AbstractThe characteristics of raindrop size distributions (DSDs) during a midlatitude continental squall line on 30 July 2014 in east China are studied, and the different life stages are observed by OTT second-generation Particle Size Velocity (Parsivel2) disdrometers at Chuzhou during the mature stage and Nanjing during the declining stage. The observed rainfall is classified into convective line, transition, and stratiform regions based on the structure of the radar reflectivity Z and rainfall intensity R. The results show that the DSD characteristics of the different precipitation types and different squall-line stages are very different. The convective center has the largest number concentration and quantity of large drops corresponding to the highest rain rate; the rain rates in the trailing edge and stratiform regions are similar, although a lower concentration of small drops is present in the latter. Between the two stages, the drop size and number concentration for the convective center decrease, although the leading edge during the declining stage has more numerous larger drops; the number concentration is similar in the stratiform rainfall, but the drops become much smaller. For the normalized distribution, the scaled spectra for the convective center are closer to an exponential distribution, and the μ value during the declining stage is larger than that during the mature stage for the stratiform region and similar during both stages for the convective center. The declining stage has a larger exponent b and smaller coefficient A in the Z–R relationship based on fits for the entire dataset. Moreover, the R(ZH, ZDR) estimator is more accurate than that when using the Z–R relation algorithm.
Benchmarking of a Physically Based Hydrologic Model
Authors: Newman Andrew J. , Mizukami Naoki , Clark Martyn P. , Wood Andrew W. , Nijssen Bart , Nearing Grey 
Published: May 2017

Abstract
The concepts of model benchmarking, model agility, and large-sample hydrology are becoming more prevalent in hydrologic and land surface modeling. As modeling systems become more sophisticated, these concepts have the ability to help improve modeling capabilities and understanding. In this paper, their utility is demonstrated with an application of the physically based Variable Infiltration Capacity model (VIC). The authors implement VIC for a sample of 531 basins across the contiguous United States, incrementally increase model agility, and perform comparisons to a benchmark. The use of a large-sample set allows for statistically robust comparisons and subcategorization across hydroclimate conditions. Our benchmark is a calibrated, time-stepping, conceptual hydrologic model. This model is constrained by physical relationships such as the water balance, and it complements purely statistical benchmarks due to the increased physical realism and permits physically motivated benchmarking using metrics that relate one variable to another (e.g., runoff ratio). The authors find that increasing model agility along the parameter dimension, as measured by the number of model parameters available for calibration, does increase model performance for calibration and validation periods relative to less agile implementations. However, as agility increases, transferability decreases, even for a complex model such as VIC. The benchmark outperforms VIC in even the most agile case when evaluated across the entire basin set. However, VIC meets or exceeds benchmark performance in basins with high runoff ratios (greater than ~0.8), highlighting the ability of large-sample comparative hydrology to identify hydroclimatic performance variations.
Urban Area Response to Flash Flood–Triggering Rainfall, Featuring Human Behavioral Factors: The Case of 22 October 2015 in Attica, Greece
Authors: Papagiannaki Katerina , Kotroni Vassiliki , Lagouvardos Kostas , Ruin Isabelle , Bezes Antonis 
Published: May 2017

Abstract
Over the past several decades, flash floods that occurred in Attica, Greece, caused serious property and infrastructure damages, disruptions in economic and social activities, and human fatalities. This paper investigated the link between rainfall and flash flood impact during the catastrophic event that affected Attica on 22 October 2015, while also addressing human risk perception and behavior as a response to flash floods. The methodology included the analysis of the space–time correlation of rainfall with the citizens’ calls to the emergency fire services for help, and the statistical analysis of people’s responses to an online behavioral survey. The results designated critical rainfall thresholds associated with flash flood impact in the four most affected subareas of the Attica region. The impact magnitude was found to be associated with the localized accumulated rainfall. Vulnerability factors, namely, population density, geographical, and environmental features, may have contributed to the differences in the impact magnitudes between the examined subareas. The analysis of the survey’s behavioral responses provided insights into peoples’ risk perception and coping responses relative to the space–time distribution of rainfall. The findings of this study were in agreement with the hypothesis that the more severe the rainfall, the higher peoples’ severity assessment and the intensity of emotional response. Deeper feelings of fear and worry were found to be related to more adjustments to the scheduled activities and travels. Additionally, being alert to the upcoming rainfall risk was found to be related to decreased worry and fear and to fewer changes in scheduled activities.
Development and evaluation of a leaflet for concerned family members and friends: ‘It’s safe to talk about suicide’
Authors: Owens Christabel , Charles Nigel 
Published: May 2017

Objectives: Significant others can play a key role in suicide prevention, but little attention has been given to the resources they may need in order to do so effectively. Based on previous qualitative research and working in partnership with suicide prevention charities, we developed a simple educational leaflet to help family members and friends recognise and respond to a possible suicidal crisis. We disseminated 15,000 copies through a wide range of community agencies within one English local authority. This paper describes the development, distribution and evaluation of the leaflet. The aim of the evaluation was to assess how the distribution strategy was working, whether the leaflet was regarded as useful and acceptable, how it was being used and whether there were any concerns about its content. Design: Interview study. Methods: We conducted two rounds of semi-structured telephone interviews with every agency on the distribution list and in-depth qualitative interviews with a purposefully selected sub-sample. Results: The leaflet was seen as filling an important gap. It was eagerly embraced by staff in frontline agencies, who passed it on to clients, used it for their own personal/professional development and to support clients or colleagues, or used it as a teaching aid. No concerns were raised about its content. Conclusion: Findings reveal a deep-seated fear of talking about suicide among frontline staff. They were using the leaflet in ways we had not anticipated, demonstrating lateral thinking and a real commitment to suicide prevention in agencies that are not typically associated with it.
Stigma experienced by caregivers of patients with severe mental disorders: A nationwide multicentric study
Authors: Grover Sandeep , Avasthi Ajit , Singh Aakanksha , Dan Amitava , Neogi Rajarishi , Kaur Darpan , Lakdawala Bhavesh , Rozatkar Abhijit R , Nebhinani Naresh , Patra Suravi , Sivashankar Priya , Subramanyam Alka A , Tripathi Adarsh , Gania Ab Majid , Singh Gurvinder Pal , Behere Prakash 
Published: May 2017

Background: Stigma is very common among caregivers of patients with severe mental disorder; however, there is lack of national level data from India. Aim: To assess affiliate stigma and its correlates among caregivers of patients with severe mental disorders. Method: For this, caregivers of patients with schizophrenia ( N = 707), bipolar disorder ( N = 344) and recurrent depressive disorder ( N = 352) were assessed on Stigma scale for Caregivers of People with Mental Illness and General Health Questionnaire. Results: Caregivers of patients with schizophrenia reported significantly higher stigma than patients with bipolar disorder and recurrent depressive disorder. Caregiver of patients with bipolar disorder reported significantly greater stigma than the caregivers of patients with recurrent depressive disorder. Higher caregiver stigma in all the diagnostic groups was associated with higher psychological morbidity in caregivers. Higher stigma in caregivers of schizophrenia was seen when the patient had younger age of onset and longer duration of treatment. In the bipolar disorder group, higher stigma in caregivers was seen when patient had higher residual manic symptoms. Conclusion: This study suggests that caregivers of patients with schizophrenia experience higher stigma than the caregivers of patients with bipolar disorder and recurrent depressive disorder. Higher stigma is associated with higher psychological morbidity in the caregivers. Therefore, the clinicians managing patients with severe mental disorders must focus on stigma and psychological distress among the caregivers and plan intervention strategies to reduce stigma.
Family group interventions in an early psychosis program: A re-evaluation of practice after 10 years of service delivery
Authors: Day Kate , Starbuck Rachael , Petrakis Melissa 
Published: May 2017

Introduction: The role of family in supporting service users in coping with illness and engaging in relapse prevention in early psychosis is important. Taking on this caring though is stressful and challenging, and it has been found that support and information for carers assists in their coping and reduces isolation. Aims: To evaluate the current utility of a psychoeducation group program in a public adult mental health service, for the families of people experiencing early psychosis. Methods: A purpose-designed pre- and post-intervention questionnaire was administered to quantitatively measure group participants’ changes in perceptions of their understanding of mental illness and its treatment through attending the group. Additional qualitative items were used to determine other knowledge, benefits and any critical feedback. Results: The group program continues to result in highly significant improvements in family members’ understanding of psychosis, recovery, medications, relapse prevention and substance co-morbidities. Additional feedback reaffirmed previous findings that family members find group peer support valuable and that this reduces isolation and the experience of stigma. Conclusion: The current evaluation, conducted following 10 years of early psychosis group work, found there to be efficacy in family peer support groups and that it is important to provide family interventions in public early psychosis mental health services.