bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics of Ulceroglandular Tularemia in Two Bulgarian Regions, 2014-2015: a Report of Five Cases
Authors: Pekova Liliya M. , Baymakova Magdalena P. , Parousheva Pavlina O. , Fartunova Mariya D. , Dimitrov Nikolay E. , Tomova Iskra A. 
Published: January 2018

AbstractWe present here the first five human cases with tularemia from two regions in South Bulgaria in which there had been no previous report of the infection. The cases occurred over a period of 8 months (December 2014 - August 2015). They were treated at the Department of Infectious Diseases in Stara Zagora University Hospital, Bulgaria. We present the clinical, epidemiological and laboratory data for four men and one woman (age range 52 to 73 years). Three men were hunters, four patients took part in handling, preparing/skinning and cooking the game animals. One man marked agricultural work and contact with straw stems. After a mean incubation period of 4.8±1.4 days ulcers appeared, followed by local painful lymphadenitis. All patients presented with liver enlargement and elevation in acute phase reactants. The etiological diagnosis was made by tube agglutination test in all cases, PCR positive result was found in one. The administered antibacterial treatment was a combination of aminoglycosides and 4-quinolones with the outcome being favorable for all patients. The current report suggests presence of Francisella tularensis in South Bulgaria.
A Look at Global Climate Change Through Papal Encyclicals
Authors: Gutry-Korycka Małgorzata 
Published: January 2018

Abstract
The aim of this article is a comprehensive review of Papal Encyclicals in the context of global environmental and climatic change, against the backdrop of the activity of multinational institutions. The Encyclicals look to the future in teaching the faithful, in a manner which indicates that they are part of a goal-oriented policy, both in terms of scientific research, and concrete economic, social, and geopolitical activity. Attention has also been paid to the relationship between the activity of humankind, and global environmental change, particularly of the biotic and climatic variety. If this aggressive anthropogenic activity cannot be deemed responsible for initiating global warming, it may certainly be seen to have “encouraged” it. The impulses behind sustainable development, as well as the instruments of its implementation, and the inspiration behind the idea, have also been discussed. The achievement of this goal, necessitating the balancing of anthropological aspirations and the long-term security of the environment are also referenced in the Encyclicals.
A Postulate for Accelerated Implementation of Sustainable Development Goals and Principles
Authors: Kassenberg Andrzej 
Published: January 2018

Abstract
The last 30-year period has been increasingly important for sustainable development, as is evidenced by the UN’s announcement of 17 Sustainable Development Goals to be achieved by 2030. However, many megatrends continue to progress in the direction opposite to that meeting the needs of sustainable development. For the Earth and human civilisation to be protected, it is necessary for a new approach to be developed - a new order that might be termed the civilization/economics of enough, or of moderation. However, convincing societies, including that of Poland, in regard to the benefits of addressing the challenges sustainable development poses is not an easy task; even though a redirecting of the economy and of society along new paths will bring measurable benefits capable of compensating for the costs of transformation.
Effect of geometrical parameters on the effective elastic modulus for an X-type lattice truss panel structure
Authors: Zhang Qian , Jiang Wenchun , Zhang Yanting 
Published: January 2018

Abstract
The lattice truss panel structure (LTPS), which is a high strength material with high efficiency of heat transfer, has a good potential to be used as compact heat exchanger. The core of LTPS is a periodic porous structure, and the effective elastic modulus (EEM) will be different from the base material. It is essential to calculate the EEM for the design of this type of heat exchanger. This paper presents a study on the EEM of X-type LTPS by homogenization method, which has been verified by finite element method (FEM). It reveals that the effects of seven geometrical parameters of the X-type LTPS on EEM are not identical, and the relationship between the seven parameters and EEM has been established. Results calculated by homogenization method and FEM show a good agreement. The EEM decreases with the increase of truss length, stamping angle, shearing angle and node length, while it increases with the increase of truss width, truss thickness and face sheet thickness. Unlike the conventional foam material, there is no clear correlation between the EEM and the relative density, and a formula has been fitted to calculate the EEM of LTPS.
Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans
Authors: Qin Zhaozhao , Johnsen Robert , Yu Shicheng , Chu Jeffrey Shih-Chieh , Baillie David L , Chen Nansheng 
Published: January 2018

Abstract
Using combined genetic mapping, Illumina sequencing, bioinformatics analyses, and experimental validation, we identified 60 essential genes from 104 lethal mutations in two genomic regions of Caenorhabditis elegans totaling ∼14 Mb on chromosome III(mid) and chromosome V(left). Five of the 60 genes had not previously been shown to have lethal phenotypes by RNA interference depletion. By analyzing the regions around the lethal missense mutations, we identified four putative new protein functional domains. Furthermore, functional characterization of the identified essential genes shows that most are enzymes, including helicases, tRNA synthetases, and kinases in addition to ribosomal proteins. Gene Ontology analysis indicated that essential genes often encode for enzymes that conduct nucleic acid binding activities during fundamental processes, such as intracellular DNA replication, transcription, and translation. Analysis of essential gene shows that they have fewer paralogs, encode proteins that are in protein interaction hubs, and are highly expressed relative to nonessential genes. All these essential gene traits in C. elegans are consistent with those of human disease genes. Most human orthologs (90%) of the essential genes in this study are related to human diseases. Therefore, functional characterization of essential genes underlines their importance as proxies for understanding the biological functions of human disease genes.
Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish
Authors: Chen Tianbing , Song Guili , Yang Huihui , Mao Lin , Cui Zongbin , Huang Kaiyao 
Published: January 2018

Abstract
Hermansky-Pudlak syndrome (HPS) is a human autosomal recessive disorder that is characterized by oculocutaneous albinism and a deficiency of the platelet storage pool resulting from defective biogenesis of lysosome-related organelles (LROs). To date, 10 HPS genes have been identified, three of which belong to the octamer complex BLOC-1 (biogenesis of lysosome-related organelles complex 1). One subunit of the BLOC-1 complex, BLOS1, also participates in the BLOC-1-related complex (BORC). Due to lethality at the early embryo stage in BLOS1 knockout mice, the function of BLOS1 in the above two complexes and whether it has a novel function are unclear. Here, we generated three zebrafish mutant lines with a BLOC-1 deficiency, in which melanin and silver pigment formation was attenuated as a result of mutation of bloc1s1, bloc1s2, and dtnbp1a, suggesting that they function in the same complex. In addition, mutations of bloc1s1 and bloc1s2 caused an accumulation of clusters of lysosomal vesicles at the posterior part of the tectum, representing a BORC-specific function in zebrafish. Moreover, bloc1s1 is highly expressed in the swimbladder during postembryonic stages and is required for positively regulating the expression of the genes, which is known to govern surfactant production and lung development in mammals. Our study identified BLOS1 as a crucial regulator of the surfactant system. Thus, the zebrafish swimbladder might be an easy system to screen and study genetic modifiers that control surfactant production and homeostasis.
Rhinovirus in Febrile Infants and Risk of Bacterial Infection
Authors: Blaschke Anne J. , Korgenski E. Kent , Wilkes Jacob , Presson Angela P. , Thorell Emily A. , Pavia Andrew T. , Knackstedt Elizabeth D. , Reynolds Carolyn , Schunk Jeff E. , Daly Judy A. , Byington Carrie L. 
Published: January 2018

BACKGROUND:
Febrile infants with viral respiratory infections have a reduced risk of bacterial infection compared with virus-negative infants. The risk of concomitant bacterial infection in febrile infants positive for human rhinovirus (HRV) by polymerase chain reaction (PCR) is unknown.

METHODS:
Infants 1–90 days old managed using the care process model for well-appearing febrile infants and with respiratory viral testing by PCR (RVPCR) in the emergency department or inpatient setting of 22 hospitals in the Intermountain Healthcare system from 2007-2016 were identified. Relative risk (RR) of bacterial infection was calculated for infants with HRV, non-HRV viruses, or no virus detected.

RESULTS:
Of 10 964 febrile infants identified, 4037 (37%) had RVPCR. Of these, 2212 (55%) were positive for a respiratory virus; 1392 (35%) for HRV alone. Bacterial infection was identified in 9.5%. Febrile infants with HRV detected were more likely to have bacterial infection than those with non-HRV viruses (7.8% vs 3.7%; P &lt; .001; RR 2.12 [95% CI 1.43–3.15]). Risk of urinary tract infection was not significantly different for HRV-positive infants at any age, nor was risk of invasive bacterial infection (IBI; bacteremia and/or meningitis) meaningfully different for infants 1–28 day olds. Infants 29–90 days old with HRV had a decreased likelihood of IBI (RR 0.52 [95% CI 0.34–0.80]).

CONCLUSIONS:
HRV is common in febrile infants. Detection did not alter risk of concomitant urinary tract infection at any age or risk of IBI in infants 1–28 days old. HRV detection may be relevant in considering risk of IBI for infants 29–90 days of age.
Pollen viability of Tepary bean (Phaseolus acutifolius A. Gray.) mutant lines under water stress conditions and inoculation with rhizobia
Authors: Crespo-Muñoz Sergio , Rivera-Peña Mariela , Rosero-Alpala Deisy Alexandra , Muñoz-Florez Jaime Eduardo , Rao Idupulapati M. , Muñoz-Florez Ligia Carmenza 
Published: January 2018

El fríjol tépari, Phaseolus acutifolius A. Gray destaca por su tolerancia al estrés por sequía y altas temperaturas, sin embargo, presenta baja diversidad genética en sus formas cultivadas. Por lo que se inició un programa de inducción de mutaciones. El objetivo de este estudio fue establecer el efecto de diferentes parámetros agro-morfofisiológicos asociados sobre la viabilidad y cantidad del polen en 123 líneas mutantes de la quinta generación M5 de P. acutifolius y genotipos parentales, por medio del procesamiento de microfotografías de preparaciones de polen con tinción de acetocarmin. El experimento se realizó en condiciones de invernadero y el diseño experimental fue de subparcelas divididas con 3 repeticiones; adicionalmente, los factores evaluados fueron: condiciones de humedad del suelo, inoculación con cepas de Bradyrhizobium sp. o Rhizobium tropici, y las líneas o accesiones evaluadas (6 mutantes y 2 no mutantes). El experimento fue realizado manteniendo la temperatura nocturna superior a 25°C. No hubo diferencias significativas entre los tratamientos, se encontraron correlaciones positivas de la viabilidad de polen con otras variables.
DISEÑO Y CALIBRACIÓN DE UN MAGNETÓMETRO DE MUESTRA VIBRANTE: CARACTERIZACIÓN DE MATERIALES MAGNÉTICOS
Authors: Guachun Freddy P. , Raposo Víctor J. 
Published: January 2018

En este trabajo se presenta el proceso seguido en la implementación de un magnetómetro de muestra vibrante (MMV), construido con materiales comúnmente encontrados en un laboratorio de electromagnetismo. Se describe el diseño, construcción, calibración y utilización en la caracterización de algunos materiales magnéticos. Un MMV mide el momento magnético de una muestra cuando se la hace vibrar perpendicularmente a un campo magnético uniforme; a partir de estas lecturas se puede determinar la magnetización y la susceptibilidad magnética. Este instrumento sobresale por su simplicidad, versatilidad y bajo costo, pero es muy sensible y capaz de eliminar o minimizar muchas fuentes de error que se encuentran en otros métodos de medición, permitiendo así obtener resultados muy precisos y confiables. Su funcionamiento se basa en la ley de inducción magnética de Lenz-Faraday que consiste en medir el voltaje inducido en unas bobinas de detección producido por la variación del flujo magnético que las atraviesa. La calibración del MMV se realizó mediante una muestra patrón (Magnetita) y se verificó mediante una muestra de comprobación (Níquel).
Programa de prevención de la enfermedad renal crónica basado en redes integradas de servicios en Colombia
Authors: Rico Landazábal Arturo , Perea Delia , Garizabalo Olger , Sanabria Mauricio , Vesga Jasmin , Ronderos Izcay , Muñoz Fabian , Laganis Stefano , López Patricia 
Published: January 2018

Objetivo Los programas de prevención de la Enfermedad Renal Crónica (ERC) permiten controlar la morbimortalidad y/o retrasar el ingreso a terapia de reemplazo renal. Se documenta el diseño de un programa de prevención de la ERC y se describe cómo se integran los niveles primario y secundario de atención mediante la caracterización de una población admitida para prevención secundaria.Métodos La descripción del programa se realizó con base en una revisión documental. Para la caracterización de los pacientes participantes en el programa se utilizaron herramientas de estadística descriptiva.Resultados El diseño e implementación del programa de prevención se basó en la integración de redes de servicios y niveles de atención. Se detallan las actividades fundamentales del programa según el nivel de atención en el que se realizan. Un total de 3 487 pacientes fueron admitidos para control en el segundo nivel de atención por presentar tasa de filtración glomerular estimada <60 mil/min; 87,81 % de los pacientes ingresó en estadio 3 de la ERC con mediana de Tasa de Filtración Glomerular de 46,21mil/min; las principales causas de ERC fueron la hipertensión arterial y la diabetes. Al ingreso, 2 129 pacientes (61.05 %) tuvieron tensión arterial sistólica <140 mmHg y 3.091(88.64 %) diastólica <90mmHg; de 620 diabéticos con hemoglobina glicosilada, 357 (57.58 %) tuvieron valores <7,5 %.Conclusión Se diseñó e implementó un programa de prevención que permitió la integración de los niveles de atención para una intervención multidisciplinaria que logró la captación oportuna de pacientes y la continuidad en la atención para el mejor control de la ERC.
Priorización para el análisis de información en salud pública, preferencias de la red de conocimiento del Observatorio Nacional de Salud
Authors: Cediel Becerra Natalia Margarita , Alvis Nelson , Moreno Montoya José , Castañeda Carlos , Vargas Sandoval Gina , Agudelo Calderon Carlos 
Published: January 2018

Objetivo Priorizar los grupos de enfermedades, población y métodos de análisis en salud pública según las preferencias de los actores de la red de conocimiento del Observatorio Nacional de Salud.Método Se utilizó el método de Análisis Conjunto (AC), que consiste en la construcción de un modelo factorial completo tomando una muestra aleatoria de sujetos que deben, según un orden de importancia pre-establecido, identificar las preferencias delos atributos de determinado constructo. Los actores de la red de conocimiento que participaron fueron profesionales de universidades públicas, miembros de EPS, IPS, secretarias de salud departamental, organizaciones sin ánimo de lucro enfocadas ensalud, centros de investigación especializados, de alcaldías, y corporaciones.Resultados Los grupos de enfermedades prioritarios fueron: trastornos mentales y del comportamiento (13,8 %), enfermedades cardiovasculares y circulatorias (13 %), neoplasmas (10 %) Diarrea, infecciones respiratorias, meningitis y otras enfermedadesinfecciosas comunes (6,7 %) y deficiencias nutricionales (6,3 %). Los criterios de priorización preferidos fueron la carga de enfermedad derivada y la dinámica epidemiológica del alto impacto. La información prioritaria de análisis fue la de determinantessociales. El grupo poblacional de mayor preferencia fue la población general.Conclusiones Se evidenció que los participantes perciben como prioritarias tanto las enfermedades crónicas como infecciosas concordante con la transición epidemiológica del país. La prioridad más sentida del sistema sanitario colombiano es la construcciónde capacidad del recurso humano y el fortalecimiento del
Modelo para el análisis de la mortalidad en Colombia 2000-2012
Authors: Giraldo Diana , Atehortúa Angélica , García-Arteaga Juan D. , Díaz-Jiménez Diana P. , Romero Eduardo , Rodríguez Jesús 
Published: January 2018

Objetivo Proponer y evaluar un modelo para el ajuste y predicción de la mortalidad en Colombia que permita analizar tendencias por edad, sexo, Departamento y causa.Metodología Los registros de defunciones no fetales fueron utilizados como fuente primaria de análisis. Estos datos se pre-procesaron recodificando las causas y redistribuyendo los códigos basura. El modelo de predicción se formuló como una aproximaciónlineal de un conjunto de variables de interés, en particular la población y el producto interno bruto departamental.Resultados Como caso particular de estudio se tomó la mortalidad de menores de 5 años, se observó una disminución sostenida a partir del año 2000 tanto a nivel nacional como departamental, con excepción de tres departamentos. La evaluación del poderpredictivo de la metodología propuesta se realizó ajustando el modelo con los datos de 2000 a 2011, la predicción para el 2012 fue comparada con la tasa observada, estos resultados muestran que el modelo es suficientemente confiable para la mayor parte de las combinaciones departamento-causa.Conclusiones La metodología y modelo propuesto tienen el potencial de convertirse en un instrumento que permita orientar las prioridades del gasto en salud utilizando algún tipo de evidencia.
Focal therapy of prostate cancer: patient selection, current limitations, and perspective of introduction into clinical practice
Authors: Vasilyev A. V. , Govorov A. V. , Shiryaev A. A. , Sukhikh S. O. , Zherdev A. A. , Shakurov A. V. , Pushkarev А. V. , Tsiganov D. I. , Pushkar D. Yu. 
Published: January 2018

Focal therapy is a promising option for localized prostate cancer treatment in low and intermediate risk patients. The combination of minimal invasiveness, disease control and the possibility of re-treatment in case of recurrence have significantly increased interest in focal therapy. However, before the final introduction of focal therapy into clinical practice, a number of significant limitations have yet to be overcome, such as patient selection, visualization of target, the choice of the treatment modality and the surgery planning, as well as the development of a follow-up protocol. Studies have shown that focal therapy has minimal impact on the quality of life, but its oncological effectiveness has yet to be evaluated in comparison with radical methods of treatment.
METODOLOGÍA BIOÉTICA PARA LA TOMA DE DECISIONES EN FAUNA SILVESTRE SOMETIDA A CAUTIVERIO
Authors: Estrada Cely Gloria Elena , Parra Herrera Juan Pablo , Ganem-Galindo Norma Constanza 
Published: January 2018

<p>El referente legal colombiano relacionado con la regulación del tráfico ilegal de fauna silvestre supone el establecimiento de estrategias de control que necesariamente generan una importante población de especímenes silvestres bajo custodia de las autoridades ambientales, que deben ser tratados de manera particular e individual, y sobre los que la toma de decisiones, desde el referente legal, superan el ámbito de lo clínico y etológico para ubicarse necesariamente en un ámbito bioético.</p><p> </p><p>Para el desarrollo de la investigación fueron empleados métodos analíticos y comparativos, a partir de la revisión del marco legal nacional en materia de uso de animales silvestres y su análisis bioético desde el cual se establecieron los lineamientos para el abordaje de casos, a partir de la construcción de una matriz bioética. Una vez desarrollado el proceso metodológico se establece que el análisis de problemáticas que involucren especímenes de la fauna silvestre requiere de un abordaje que combine efectivamente referentes filosóficos, éticos, bioéticos, científicos y legales, procurando la resolución de cada caso, dentro del marco de calidad de vida del animal y la protección de la vida humana y el ecosistema, para el cual resulta efectiva la Metodología<em> </em>propuesta en la investigación.</p>
Incidence of Thyroid Diseases in Saudi Diabetic Patients by Means of Ultrasonography
Authors: Elsayed Naglaa Mostafa , Hakami Amnah , Al-Sulami Bashayer , Al-Sulami Anwar , Alzhrani Maram 
Published: January 2018

Introduction: Both thyroid diseases and diabetes mellitus (DM) are common in medical practice in Saudi Arabia. This research was done to study the possible relation between these two diseases.
Materials and Methods: A prospective case control study was carried out to assess thyroid abnormalities by Ultrasound (US) in diabetic patients (type 1 and type 2 ).The study population consisted of 69 diabetic patients (20 Type 1DM and 49 Type 2DM) and 111 non diabetic patients. Thyroid US was done for all participants and thyroid function test mainly thyroid stimulating hormone (TSH) was done for all cases that showed positive US changes for thyroid abnormalities.
Results: Abnormal thyroid US was detected in 66.7% of diabetic and 34.2% of non diabetic participants. Multinodular goitre (MNG) was the most common disorder in both types of DM (78.6% in DMT1 and 56.3% in DMT2), while thyroid nodules were the least common disorder. No significant difference between diabetic and non diabetic patients in TSH results.
Conclusion and Recommendations: The present study showed high prevalence of thyroid disorder in diabetic patients. We recommend routine US for all diabetic patients especially those with long term diabetes, uncontrolled diabetes or complaining of symptoms of thyroid dysfunction.
Economic analysis of traditional coconut oil production in Aceh Besar, Indonesia
Authors: * Rahmattullah , . Muhammad , Ismail Muhammad Nasir 
Published: January 2018

The purpose of this study was to analyse the rentability and profit of traditional coconut oil production.Primary data was obtained by using survey method. Data collection techniques are conducted by census.The processing of oil is done by 6 respondents fermentation and 6 respondents cooking coconut milk. Theresults show that coconut oil production cooking coconut milk is more advantageous in terms of rentabilityand profit. The recommendation given is that the rural mothers switch from fermentation to cooking ofcoconut milk