bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes
Authors: López‐Sainz Ángela , Barge‐Caballero Eduardo , Barge‐Caballero Gonzalo , Couto‐Mallón David , Paniagua‐Martin María J. , Seoane‐Quiroga Leticia , Iglesias‐Gil Carmen , Herrera‐Noreña José M. , Cuenca‐Castillo José J. , Vázquez‐Rodríguez José M. , Crespo‐Leiro María G. 
Published: June 2017

AbstractAimTo analyse the incidence, risk factors and clinical outcomes of late graft failure after heart transplantation.Methods and resultsWe conducted an observational, single‐centre study based on 547 patients who underwent cardiac transplantation from 1991 to 2014 and who survived the in‐hospital postoperative period. Late graft failure was defined as the first hospitalization due to this condition after discharge. Over a mean follow‐up of 8.4 ± 6 years, 178 (32.5%) patients were hospitalized due to late graft failure [incidence rate: 3.6 cases per 100 patient‐years, 95% confidence interval (CI) 3.1–4.2]. Pre‐transplant diabetes, higher pre‐transplant transpulmonary pressure gradient and lower donor–recipient weight ratio were independently associated with higher risk of graft failure. Cardiac allograft vasculopathy, cellular rejection grade ≥1R, and antibody‐mediated rejection grade ≥1 were detected in 50.6%, 44.9% and 19.2% patients, respectively, admitted due to graft failure. Left ventricular ejection fraction was ≥50% in 60.1% of these patients. Re‐transplant free survival 1, 5, 10 and 15 years after the diagnosis of late graft failure was 72.2%, 38.4%, 18.4%, and 7.5%, respectively; the incidence rate of re‐hospitalization due to decompensated heart failure was 40.9 episodes per 100 patient‐years (95% CI 36.6–46.1). The need for inotropes, the presence of cardiac allograft vasculopathy, higher creatinine serum levels, lower ejection fraction and lower sodium serum levels were independent predictors of worse outcomes.ConclusionsLate graft failure is frequent after heart transplantation, as it is associated with poor outcomes. Rejection and cardiac allograft vasculopathy are the most frequent underlying causes.
Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT‐CHF
Authors: Ferreira João Pedro , Rossignol Patrick , Machu Jean‐Loup , Sharma Abhinav , Girerd Nicolas , Anker Stefan D. , Cleland John G. , Dickstein Kenneth , Filippatos Gerasimos , Hillege Hans L. , Lang Chim C. , ter Maaten Jozine M. , Metra Marco , Ng Leong , Ponikowski Piotr , Samani Nilesh J. , van Veldhuisen Dirk J. , Zwinderman Aeilko H. , Voors Adriaan , Zannad Faiez 
Published: June 2017

AbstractAimsMineralocorticoid receptor antagonists (MRAs) are recommended (unless contraindicated) to all patients with heart failure with reduced ejection fraction (HFrEF). However, MRAs are still largely underused in routine clinical practice. This study aims to describe the determinants and pattern of use of MRAs in HFrEF.Methods and resultsBIOSTAT‐CHF is a European multicentre, prospective study which enrolled patients suboptimally treated with angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs) and/or beta‐blockers, with the aim of optimizing guideline‐based use of these agents. From the original 2516 subjects, this retrospective post hoc analysis included the 1325 patients with an indication for MRA therapy (i.e. left ventricular ejection fraction ≤35%, estimated glomerular filtration rate ≥30 mL/min/1.73 m2, K+ ≤5.0 mmol/L). The mean age was 66.1 ± 12.2 years. At baseline an MRA was prescribed to 741 (56%) patients. Patients who were prescribed MRAs at baseline were younger, more often male, had higher body mass index, lower sodium, higher proportion of hypertension history and ACEi/ARB prescription (all P < 0.05). Of the 1049 patients who completed the baseline plus the 9 month visit, 585 (56%) had an MRA prescribed at baseline and 662 (63%) had an MRA prescribed at 9 months. Among the 585 patients with MRA at baseline, 91 (16%) had discontinued therapy and among the 461 (44%) patients without MRA at baseline 168 (36%) had initiated therapy subsequently. MRA discontinuation was more likely in subjects with higher left ventricular ejection fraction and NYHA class III/IV (P < 0.05 for both). MRA prescription both at baseline and 9 months was not associated with the outcome of death or heart failure hospitalization (adjusted hazard ratio 1.02, 95% confidence interval 0.66–1.58; P = 0.93).ConclusionsIn this prospective observational study across Europe, MRAs were largely under‐prescribed and frequently discontinued. Owing to these dynamic changes, outcome inferences are inconclusive.
Monolithic columns: A historical overview
Authors: Svec Frantisek 
Published: June 2017

AbstractThis review article is an updated and extended version of the previous review that has been published 14 years ago . Although history does not change, its interpretation may. Therefore, I took the liberty to revisit the original work and added some of my new thoughts that could be interesting for the generation of scientists who are entering the intriguing arena of monoliths and may want to know the roots of the field. The current monolithic columns that are well applicable for efficient separations, were first described less than 30 years ago, and their advent represented the initial step to their present widespread appearance. At the beginning, the monolithic columns dominated the academic studies. However, several monolithic materials have later been materialized in commercial products. In order to stay within a reasonable size of this contribution, its focus is placed on developments achieved in the previous century. The very early reports are described in more detail since it might be difficult to find the original source.
Hollow‐Fiber‐Supported Gold and Zirconium‐Doped Faujasite Catalytic Membranes for Hydrogen Purification
Authors: Zhu Feng , Peng Li , Yao Xun , Zhang Yuting , Zhang Chun , Gu Xuehong 
Published: June 2017

AbstractHollow‐fiber‐supported Au‐Zr/faujasite (FAU, NaY) catalytic membranes were prepared and used as a flow‐through catalytic membrane reactor for CO preferential oxidation (CO‐PROX) in H2‐rich gas. The catalytic membranes were prepared by the modification of FAU zeolite membranes with Zr4+ and Au3+ by ion‐exchange, then activation. The obtained catalytic membranes were characterized by using TEM, X‐ray photoelectron spectroscopy, temperature‐programmed reduction, and temperature‐programmed desorption and their catalytic activity toward CO‐PROX was tested. The results showed that the activation conditions affected the size and oxidation states of the resulting Au nanoparticles strongly, and therefore, affected the catalytic activity strongly. The catalytic activity of the Au nanoparticles can be improved by the doping of Zr to form surface oxygen vacancies and the synergetic effect of Au‐Zr. Meanwhile, the presence of the zeolite framework allows the stabilization of small Au nanoparticles. The Au‐Zr/FAU catalytic membrane prepared under the optimized conditions showed a high catalytic performance (CO conversion above 95 %, turnover frequency>0.4 s−1) and outstanding stability (up to 450 h) below 80 °C, which made it a promising candidate for H2 purification.
Eucalyptus oil inhalation–induced seizure: A novel, underrecognized, preventable cause of acute symptomatic seizure
Authors: Mathew Thomas , Kamath Vikram , Kumar R. Shiva , Srinivas Meghana , Hareesh Prarthana , Jadav Rakesh , Swamy Sreekanta 
Published: June 2017

SummaryEucalyptus oil (EO) is an essential oil that is widely used across the globe as an over‐the‐counter remedy for common ailments. EO‐induced seizure (EOIS) has not been recognized as an entity, and physicians rarely ask the history of exposure to eucalyptus oil when seeing a patient with first episode of seizure. Here we report 10 cases of EO inhalation–induced seizures seen over the past 2 years in three tertiary care hospitals. Eight patients had GTCS and two had CPS. We aim to raise awareness of seizures induced by exposure to eucalyptus oil.
Exploring Methods for Developing Behaviorally Anchored Rating Scales for Evaluating Structured Interview Performance
Authors: Kell Harrison J. , Martin‐Raugh Michelle P. , Carney Lauren M. , Inglese Patricia A. , Chen Lei , Feng Gary 
Published: June 2017

AbstractBehaviorally anchored rating scales (BARS) are an essential component of structured interviews. Use of BARS to evaluate interviewees' performance is associated with greater predictive validity and reliability and less bias. BARS are time‐consuming and expensive to construct, however. This report explores the feasibility of gathering participants' responses to structured interview questions through an online crowdsourcing platform and using those responses to develop BARS. We describe the development of 12 structured interview questions to assess four applied social skills, elicitation of responses to these questions in the form of critical incidents from 68 respondents, and the creation of BARS from these critical incidents. Results indicate online participants are able to produce responses of sufficient quality to generate BARS for evaluating structured interview performance. We conclude by discussing limitations to this approach and future directions for research and practice.
Captisol®: an efficient carrier and solubilizing agent for essential oils and their components
Authors: Kfoury Miriana , Pipkin J.D. , Antle Vince , Fourmentin Sophie 
Published: June 2017

AbstractEssential oils (EOs) and their individual components have several biological properties and are used in cosmetics, food and pharmaceutical industries. However, their application still presents a challenge owing mainly to their volatility and their poor aqueous solubility and stability. The aim of this study was to evaluate, for the first time, the ability of Captisol® (sulfobutylether‐β‐cyclodextrin, SBE‐β‐CD) and Captisol‐G® (sulfobutylether‐γ‐cyclodextrin, SBE‐γ‐CD) to encapsulate the main volatile components of six essential oils (EOs), to enhance the aqueous solubility of these EOs and to generate controlled release systems. The performance of these CDs was compared to hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) and γ‐cyclodextrin (γ‐CD), respectively. Formation constants (Kf) of the 40 inclusion complexes were determined by Static Headspace‐Gas Chromatography (SH‐GC). Then, Total Organic Carbon (TOC) was used to explore and quantify the efficiency of Captisol® and HP‐β‐CD to enhance the solubility of the six EOs. Finally, multiple headspace extraction (MHE) was applied to perform release studies. Kf values underlined the best binding potential of Captisol® towards all guests. Phase solubility diagrams showed that both Captisol® and HP‐β‐CD greatly increased the apparent solubility of EOs. The solubilizing potential was inversely proportionate to the EOs intrinsic solubility (SEO). Results indicated that Captisol® can successfully encapsulate EOs, increase their apparent aqueous solubility and decrease their release kinetics. Thus, Captisol® could be considered as a promising carrier to enlarge the application of EOs and their components.
Region‐based association tests for sequencing data on survival traits
Authors: Chien Li‐Chu , Bowden Donald W. , Chiu Yen‐Feng 
Published: June 2017

ABSTRACTFamily‐based designs enriched with affected subjects and disease associated variants can increase statistical power for identifying functional rare variants. However, few rare variant analysis approaches are available for time‐to‐event traits in family designs and none of them applicable to the X chromosome. We developed novel pedigree‐based burden and kernel association tests for time‐to‐event outcomes with right censoring for pedigree data, referred to FamRATS (family‐based rare variant association tests for survival traits). Cox proportional hazard models were employed to relate a time‐to‐event trait with rare variants with flexibility to encompass all ranges and collapsing of multiple variants. In addition, the robustness of violating proportional hazard assumptions was investigated for the proposed and four current existing tests, including the conventional population‐based Cox proportional model and the burden, kernel, and sum of squares statistic (SSQ) tests for family data. The proposed tests can be applied to large‐scale whole‐genome sequencing data. They are appropriate for the practical use under a wide range of misspecified Cox models, as well as for population‐based, pedigree‐based, or hybrid designs. In our extensive simulation study and data example, we showed that the proposed kernel test is the most powerful and robust choice among the proposed burden test and the existing four rare variant survival association tests. When applied to the Diabetes Heart Study, the proposed tests found exome variants of theJAK1gene on chromosome 1 showed the most significant association with age at onset of type 2 diabetes from the exome‐wide analysis.
Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT‐1 via σ1 receptor‐mediated PKC activation in the hippocampal dentate gyrus of rats
Authors: Chen Tingting , Tanaka Motoki , Wang Ya , Sha Sha , Furuya Kishio , Chen Ling , Sokabe Masahiro 
Published: June 2017

AbstractNeurosteroid dehydroepiandrosterone (DHEA) has been reported to exert a potent neuroprotective effect against glutamate‐induced excitotoxicity. However, the underlying mechanism remains to be elucidated. One of the possible mechanisms may be an involvement of astrocytic glutamate transporter subtype‐1 (GLT‐1) that can quickly clear spilled glutamate at the synapse to prevent excitotoxicity. To examine the effect of DHEA on GLT‐1 activity, we measured synaptically induced glial depolarization (SIGD) in the dentate gyrus (DG) of adult rats by applying an optical recording technique to the hippocampal slices stained with voltage‐sensitive dye RH155. Bath‐application of DHEA for 10 min dose‐dependently increased SIGD without changing presynaptic glutamate releases, which was sensitive to the GLT‐1 blocker DHK. Patch‐clamp recordings in astrocytes showed that an application of 50 μM DHEA increased glutamate‐evoked inward currents (Iglu) by approximately 1.5‐fold, which was dependent on the GLT‐1 activity. In addition, the level of biotinylated GLT‐1 protein in the surface of astrocytes was significantly elevated by DHEA. The DHEA‐increased SIGD, Iglu, and GLT‐1 translocation to the cell surface were blocked by the σ1R antagonist NE100 and mimicked by the σ1R agonist PRE084. DHEA elevated the phosphorylation level of PKC in a σ1R‐dependent manner. Furthermore, the PKC inhibitor chelerythrine could prevent the DHEA‐increased SIGD, Iglu, and GLT‐1 translocation. Collectively, present results suggest that DHEA enhances the activity and translocation to cell surface of astrocytic GLT‐1 mainly via σ1R‐mediated PKC cascade.
Prognostic value of lymphovascular invasion of the primary tumor in hypopharyngeal carcinoma after total laryngopharyngectomy
Authors: Saito Yuki , Omura Go , Yasuhara Kazuo , Rikitake Ryoko , Akashi Ken , Fukuoka Osamu , Yoshida Masafumi , Ando Mizuo , Asakage Takahiro , Yamasoba Tatsuya 
Published: June 2017

AbstractBackgroundWe aimed to determinate the prognostic value of lymphovascular invasion in the specimens resected during total laryngopharyngectomy for hypopharyngeal carcinoma.MethodsPatients who underwent total laryngopharyngectomy at our institution between 2004 and 2014 were included in this study and retrospectively analyzed. We then discriminated for vascular invasion and lymphatic invasion of the primary tumor in all cases.ResultsWe reviewed 135 records (120 men and 15 women; age range, 36–84 years). Tumors with lymphatic invasion tended to be associated with more metastatic lymph nodes and extracapsular spread (ECS) of metastatic lymph nodes. Tumors with vascular invasion tended to be associated with nonpyriform sinus locations. In a multivariate analysis, nonpyriform sinus locations, >3 metastatic lymph nodes, and vascular invasion remained significant prognostic factors for overall survival (OS); in recursive partitioning analysis, ECS and vascular invasion remained important categorical variables for OS.ConclusionVascular invasion is a strong prognostic biomarker for advanced hypopharyngeal carcinoma. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1535–1543, 2017
Morphologic and topographic radiologic features of human papillomavirus‐related and –unrelated oropharyngeal carcinoma
Authors: Chan Michael W. , Yu Eugene , Bartlett Eric , O'Sullivan Brian , Su Jie , Waldron John , Ringash Jolie , Bratman Scott V. , Chen Yingming Amy , Irish Jonathan , Kim John , Gullane Patrick , Gilbert Ralph , Chepeha Douglas , Perez‐Ordonez Bayardo , Weinreb Ilan , Hansen Aaron , Tong Li , Xu Wei , Huang Shao Hui 
Published: June 2017

AbstractBackgroundThe purpose of this study was to compare the clinicoradiologic characteristics of human papillomavirus (HPV)‐related (HPV‐positive) and HPV‐unrelated (HPV‐negative) oropharyngeal carcinoma (OPC).MethodsPrimary tumor and lymph node features of HPV‐positive and HPV‐negative OPCs from 2008 to 2013 were compared on pretreatment CT/MRI. Intrarater/interrater concordance was assessed. Multivariable analyses identified factors associated with HPV‐positivity to be used in nomogram construction.ResultsCompared to HPV‐negative (n = 194), HPV‐positive (n = 488) tumors were more exophytic (73% vs 63%; p = .02) with well‐defined border (58% vs 47%; p = .033) and smaller axial dimensions; lymph node involvement predominated (89% vs 69%; p < .001) with cystic appearance (45% vs 32%; p = .009) but similar topography. Intrarater/interrater concordance varied (fair to excellent). Nomograms combining clinical (age, sex, smoking pack‐years, subsite, T/N classification) and/or radiologic (nonnecrotic tumor and cystic lymph node) features were used to weigh the likelihood of HPV‐driven tumors (area under the curve [AUC] = 0.84).ConclusionHPV‐positive OPC has different radiologic tumor (exophytic/well‐defined border/smaller axial dimension) and lymph node (cystic) features but similar lymph node topography.
Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients with oral cancer
Authors: D'Souza Wendy , Pradhan Sultan , Saranath Dhananjaya 
Published: June 2017

AbstractBackgroundOral cancer has a high incidence primarily because of tobacco chewing habits. However, a small proportion of habitués develop oral cancer, implying a role for genomic variants in its susceptibility.MethodsThirteen single nucleotide polymorphisms (SNPs) in an Indian cohort comprising patients with oral cancer (n = 500) and healthy controls (n = 500) were genotyped using allelic discrimination real‐time polymerase chain reaction (PCR).ResultsPrevalence of SNPs rs11130760, rs1957358, rs2306058, rs4883543, rs12637722, rs1457115, rs2353292, rs709821, rs2194861, rs4789378, rs3827538, rs2667552, and rs2886093 was determined in the Indian cohort. A significant association of rs11130760 GG (odds ratio [OR] 1.41; 95% confidence interval [CI] 1.08‐1.84) and rs1957358 TT (OR 1.44; 95% CI 1.10‐1.90) indicated increased risk; whereas rs1957358 TC (OR 0.67; 95% CI 0.53‐0.87) and rs2306058 CT (OR 0.72; 95% CI 0.56‐0.93) reflected decreased risk. The SNP rs11130760 wild‐type (WT) allele G indicated an increased risk for oral cancer (OR 1.38; 95% CI 1.09‐1.73), whereas SNP allele T indicated a decreased risk (OR 0.73; 95% CI 0.58‐0.92) for oral cancer.ConclusionOur study identified SNPs with susceptibility to oral cancer in high‐risk populations.
Case report of a primary effusion lymphoma successfully treated with oral valganciclovir after failing chemotherapy
Authors: Marquet Juan , Velazquez‐Kennedy Kyra , López Sandra , Benito Amparo , Blanchard María‐Jesús , Garcia‐Vela Jose Antonio 
Published: June 2017

AbstractPrimary effusion lymphoma is a rare non‐Hodgkin lymphoma that presents with pleural effusions and lacking of tumour mass. It is universally associated with human herpesvirus 8 (HHV8) and is more frequent among immunosuppressed patients. There is no standard treatment, chemotherapy and anti‐HIV therapy have been used with poor results, but there is still no strong evidence supporting the use of valganciclovir. We present the case of a HIV positive man that presented with pleural effusion compatible with primary effusion lymphoma and positivity for HHV8 DNA in blood. Bortezomib‐containing treatment protocol was started, but the disease progressed within the chemotherapy. Therefore, treatment with oral valganciclovir was decided and the patient achieved a sustained radiological complete response. HHV8 DNA turned negative 6 months after starting the treatment with valganciclovir.
Three‐dimensional patterning in biomedicine: Importance and applications in neuropharmacology
Authors: Vikram Singh Ajay , Gharat Tanmay , Batuwangala Madu , Park Byung‐Wook , Endlein Thomas , Sitti Metin 
Published: June 2017

AbstractNature manufactures biological systems in three dimensions with precisely controlled spatiotemporal profiles on hierarchical length and time scales. In this article, we review 3D patterning of biological systems on synthetic platforms for neuropharmacological applications. We briefly describe 3D versus 2D chemical and topographical patterning methods and their limitations. Subsequently, an overview of introducing a third dimension in neuropharmacological research with delineation of chemical and topographical roles is presented. Finally, toward the end of this article, an explanation of how 3D patterning has played a pivotal role in relevant fields of neuropharmacology to understand neurophysiology during development, normal health, and disease conditions is described. The future prospects of organs‐on‐a‐‐like devices to mimic patterned blood–brain barrier in the context of neurotherapeutic discovery and development for the prioritization of lead candidates, membrane potential, and toxicity testing are also described. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1369–1382, 2018.