bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relativistic SZ temperatures and hydrostatic mass bias for massive clusters in the FLAMINGO simulations
Authors: Kay Scott T , Braspenning Joey , Chluba Jens , Helly John C , Kugel Roi , Schaller Matthieu , Schaye Joop 
Published: September 2024

ABSTRACT
The relativistic Sunyaev-Zel’dovich (SZ) effect can be used to measure intracluster gas temperatures independently of X-ray spectroscopy. Here, we use the large-volume FLAMINGO simulation suite to determine whether SZ y-weighted temperatures lead to more accurate hydrostatic mass estimates in massive ($M_{\rm 500c} \gt 7.5\times 10^{14}\, {\rm M}_{\odot }$) clusters than when using X-ray spectroscopic-like temperatures. We find this to be the case, on average. The median bias in the SZ mass at redshift zero is $\left\langle b \right\rangle \equiv 1-\left\langle M_{\rm 500c,hse}/M_{\rm 500c,true} \right\rangle = -0.05 \pm 0.01$, over 4 times smaller in magnitude than the X-ray spectroscopic-like case, $\left\langle b \right\rangle = 0.22 \pm 0.01$. However, the scatter in the SZ bias, $\sigma _{b} \approx 0.2$, is around 40 per cent larger than for the X-ray case. We show that this difference is strongly affected by clusters with large pressure fluctuations, as expected from shocks in ongoing mergers. Selecting the clusters with the best-fitting generalized NFW pressure profiles, the median SZ bias almost vanishes, $\left\langle b \right\rangle = -0.009 \pm 0.005$, and the scatter is halved to $\sigma _{b} \approx 0.1$. We study the origin of the SZ/X-ray difference and find that, at $R_{\rm 500c}$ and in the outskirts, SZ weighted gas better reflects the hot, hydrostatic atmosphere than the X-ray weighted gas. The SZ/X-ray temperature ratio increases with radius, a result we find to be insensitive to variations in baryonic physics, cosmology, and numerical resolution.
HaploSweep: Detecting and Distinguishing Recent Soft and Hard Selective Sweeps through Haplotype Structure
Authors: Zhao Shilei , Chi Lianjiang , Fu Mincong , Chen Hua 
Published: September 2024

Abstract
Identifying soft selective sweeps using genomic data is a challenging yet crucial task in population genetics. In this study, we present HaploSweep, a novel method for detecting and categorizing soft and hard selective sweeps based on haplotype structure. Through simulations spanning a broad range of selection intensities, softness levels, and demographic histories, we demonstrate that HaploSweep outperforms iHS, nSL, and H12 in detecting soft sweeps. HaploSweep achieves high classification accuracy—0.9247 for CHB, 0.9484 for CEU, and 0.9829 YRI—when applied to simulations in line with the human Out-of-Africa demographic model. We also observe that the classification accuracy remains consistently robust across different demographic models. Additionally, we introduce a refined method to accurately distinguish soft shoulders adjacent to hard sweeps from soft sweeps. Application of HaploSweep to genomic data of CHB, CEU, and YRI populations from the 1000 genomes project has led to the discovery of several new genes that bear strong evidence of population-specific soft sweeps (HRNR, AMBRA1, CBFA2T2, DYNC2H1, and RANBP2 etc.), with prevalent associations to immune functions and metabolic processes. The validated performance of HaploSweep, demonstrated through both simulated and real data, underscores its potential as a valuable tool for detecting and comprehending the role of soft sweeps in adaptive evolution.
Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3
Authors: Yang Chun , Basnet Pratik , Sharmin Samah , Shen Hui , Kaplan Craig D , Murakami Kenji 
Published: September 2024

Abstract
RNA polymerase II (pol II) initiates transcription from transcription start sites (TSSs) located ∼30–35 bp downstream of the TATA box in metazoans, whereas in the yeast Saccharomyces cerevisiae, pol II scans further downstream TSSs located ∼40–120 bp downstream of the TATA box. Previously, we found that removal of the kinase module TFIIK (Kin28–Ccl1–Tfb3) from TFIIH shifts the TSS in a yeast in vitro system upstream to the location observed in metazoans and that addition of recombinant Tfb3 back to TFIIH-ΔTFIIK restores the downstream TSS usage. Here, we report that this biochemical activity of yeast TFIIK in TSS scanning is attributable to the Tfb3 RING domain at the interface with pol II in the pre-initiation complex (PIC): especially, swapping Tfb3 Pro51—a residue conserved among all fungi—with Ala or Ser as in MAT1, the metazoan homolog of Tfb3, confers an upstream TSS shift in vitro in a similar manner to the removal of TFIIK. Yeast genetic analysis suggests that both Pro51 and Arg64 of Tfb3 are required to maintain the stability of the Tfb3–pol II interface in the PIC. Cryo-electron microscopy analysis of a yeast PIC lacking TFIIK reveals considerable variability in the orientation of TFIIH, which impairs TSS scanning after promoter opening.
Comparative effectiveness of netupitant-palonosetron plus dexamethasone versus aprepitant-based regimens in mitigating chemotherapy-induced nausea and vomiting: a meta-analysis of randomized controlled trials
Authors: Luo Wun-Ting , Chang Chia-Lun , Huang Tsai-Wei , Gautama Made Satya Nugraha 
Published: September 2024

Abstract

Background
Despite guidelines for managing chemotherapy-induced nausea and vomiting (CINV), there remains a need to clarify the optimal use of neurokinin-1 (NK1) receptor antagonists. Comparing the effectiveness of NEPA (netupitant-palonosetron) plus dexamethasone with other NK1 antagonist-based regimens combined with a 5HT3 receptor antagonist and dexamethasone is crucial for informed decision-making and improving patient outcomes.

Methods
We conducted a systematic review of the literature to assess randomized controlled trials (RCTs) comparing the efficacy, safety, and cost-effectiveness of NEPA plus dexamethasone and other NK1 antagonist-based regimens combined with a 5HT3 receptor antagonist and dexamethasone. PubMed, Embase, and the Cochrane Library databases were systematically searched, with the latest update performed in December 2023. Data on patient demographics, chemotherapy regimen characteristics, and outcomes were extracted for meta-analysis using a random-effects model.

Results
Seven RCTs were analyzed. NEPA plus dexamethasone showed superior efficacy in achieving complete response in the overall (risk ratio [RR], 1.15; 95% CI, 1.02--1.30) and delayed phases (RR, 1.20; 95% CI, 1.03-1.41) of chemotherapy. It was more effective in controlling nausea (overall phase RR, 1.20; 95% CI, 1.05-1.36; delayed phase RR, 1.21; 95% CI, 1.05-1.40) and reducing rescue therapy use (overall phase RR, 1.45; 95% CI, 1.07-1.95; delayed phase RR, 1.75; 95% CI, 1.10-2.78). Adverse event rates were comparable (RR, 1.03; 95% CI, 0.96-1.10). Subgroup analysis indicated NEPA’s particular efficacy in patients receiving moderately emetogenic chemotherapy (RR, 1.31; 95% CI, 1.07-1.60).

Conclusion
NEPA plus dexamethasone regimens exhibit superior efficacy in preventing CINV, supporting their preferential inclusion in prophylactic treatment protocols. Its effective symptom control, safety profile, and cost-effectiveness endorse NEPA-based regimens as a beneficial option in CINV management.
Feasibility and tolerability of anlotinib plus PD-1 blockades as rechallenge immunotherapy in previously treated advanced ESCC: a retrospective study
Authors: Hong Yonggui , Liu Jun , Lu Ping , Chang Zhiwei , Zhang Guifang , Ma Xiumei , Liang Wei , Tian Yongjing , Xia Jin , Cao Heng , Huang Jing 
Published: September 2024

Abstract

Background
Rechallenge with immune checkpoint inhibitor (ICI) seemed favorable in several tumors, but clinical experience on esophageal squamous cell carcinoma (ESCC) was scanty. This real-world study aimed to assess the feasibility and safety of anlotinib plus ICI for patients with previously ICI-treated advanced ESCC.

Materials and Methods
We retrospectively identified advanced ESCC patients who received anlotinib plus ICI in the rechallenge setting for evaluation of clinical outcomes and safety. Totally 110 ICI-pretreated patients, of which 89 (80.9%) received prior first- or second-line treatment, were included from September 9, 2019, to November 30, 2022. Most patients (63.6%) discontinued initial ICI due to disease progression.

Results
After rechallenge, median overall survival (OS) and progression-free survival (PFS) were 11.1 (95% CI, 8.6-13.7) and 5.6 (95% CI, 4.4-6.8) months, respectively; estimated OS and PFS rates at 12 months were 47.6% (95% CI, 36.8%-57.7%) and 21.4% (95% CI, 10.9%-34.2%), respectively. No complete response was reported and 21 (19.1%) patients attained partial response; the objective response rate was 19.1%. Fifty-five (50.0%) had stable disease for a disease control rate of 69.1%. Of the 21 responders, median duration of response was 6.4 months. Tendencies for longer OS were observed in patients with Eastern Cooperative Oncology Group Performance of 0 (P = .056). The incidence of grade 3 or higher treatment-related adverse events was 10.0%.

Conclusion
Anlotinib plus ICI in the rechallenge setting was promising and resulted in encouraging benefits for patients with previously ICI-treated advanced ESCC. Our findings provided preliminary but unique evidence to help select ESCC patients benefiting from this strategy.

Trial registration
chictr.org.cn; number ChiCTR2300070777
Selective insensitivity to income held by the richest
Authors: Szaszi Barnabas , Habibnia Hooman , Tan Josephine , Hauser Oliver P , Jachimowicz Jon M 
Published: September 2024

Abstract
The misperception of income inequality is often touted as a critical barrier to more widespread support of redistributive policies. Here, we examine to what extent and why (mis)perceptions vary systematically across the income distribution. Drawing on data from four studies (N = 2,744)—including a representative sample and preregistered incentive-compatible experiments—we offer converging evidence that people specifically underestimate the amount of income held by the top of the income distribution. While this selective underestimation is likely driven by multiple mechanisms, including systemic factors, we find that cognitive biases contribute to the observed pattern of results. The rise of inequality in many developed countries has been documented before, and the fact that this growing inequality is largely driven by the outsized gains of the richest individuals may pose new challenges previously underappreciated: our theory and findings highlight that cognitive biases pose a key obstacle to people's recognition of the concentration of income among the richest individuals, and may potentially distort their preferences for redistribution. We conclude by discussing future directions for research and the importance of incorporating behavioral and cognitive limitations into the design of redistributive public policy.
Leveraging body-worn camera footage to assess the effects of training on officer communication during traffic stops
Authors: Camp Nicholas P , Voigt Rob , Hamedani MarYam G , Jurafsky Dan , Eberhardt Jennifer L 
Published: September 2024

Abstract
Can training police officers on how to best interact with the public actually improve their interactions with community members? This has been a challenging question to answer. Interpersonal aspects of policing are consequential but largely invisible in administrative records commonly used for evaluation. In this study, we offer a solution: body-worn camera footage captures police–community interactions and how they might change as a function of training. Using this footage-as-data approach, we consider changes in officers’ communication following procedural justice training in Oakland, CA, USA, one module of which sought to increase officer-communicated respect during traffic stops. We applied natural language processing tools and expert annotations of traffic stop recordings to detect whether officers enacted the five behaviors recommended in this module. Compared with recordings of stops that occurred prior to the training, we find that officers employed more of these techniques in posttraining stops; officers were more likely to express concern for drivers’ safety, offer reassurance, and provide explicit reasons for the stop. These methods demonstrate the promise of a footage-as-data approach to capture and affect change in police–community interactions.
The labor of assetization: producing ‘hypergrowth’ inside a tech startup
Authors: Shestakofsky Benjamin 
Published: September 2024

Abstract
Venture capitalists maximize profits not by ‘squeezing’ efficiencies out of established companies, but instead by promoting ceaseless experimentation aimed at helping startups achieve ‘hypergrowth’. To date, there is limited empirical evidence of both how startups achieve hypergrowth, and the impact of these practices on organizations and workers. This article draws on 19 months of participant-observation research inside a venture-backed startup I call AllDone to trace the links between the institution of venture capital and the organization of work. Although AllDone executives engaged in cost-cutting strategies common to other financialized firms, they also developed distinctive corporate strategies and organizational structures. Each of the company’s three work teams was organized to perform interdependent functions in support of venture capital’s imperative for rapid and exponential asset value inflation. I conclude with a discussion of the article’s implications for research on venture capital, startup work, and the relationship between financialization and work more broadly.
Revisiting Criminal Law Bills: An In-Depth Critical Analysis of Bharatiya Nyaya Sanhita Bill and Bharatiya Nagarik Suraksha Bill
Authors: Bajpai Arushi , Gupta Akash , Indusekhar Akshath 
Published: September 2024

Abstract
In an attempt to revise the criminal laws, India has introduced three new criminal law bills in the Lok Sabha in August 2023, which later received a few recommendations from the parliamentary committee and recently got a nod from the President of India. These bills have been diligently formulated after consultation with the apex court, the high courts, some of the most renowned law universities in the country, and other experts in the field. However, there have been a lot of drafting errors in the new bills. Since the time it has been introduced, it has been highly criticized by all the scholars and lawyers across the nation. The idea of overhauling the criminal law acts was to go away from the colonial law provisions and frame the laws with Indian context. The IPC will be changed after around 163 years. However, the author believes that the colonial laws remain intact in the new bills. This article has seen all the changes that new bills are cringing providing special focus to the Bharatiya Nyaya Sahinta (BNS) and Bharatiya Nagarik Suraksha Sanhita, 2023 (BNSS). The author has mentioned all the changes brought in the BNS and BNSS and the critiques of the new bills.
Nearly instantaneous stem diameter response to fluctuations in the atmospheric water demand
Authors: Salomón Roberto L , Puértolas Jaime , Miranda José Carlos , Pita Pilar 
Published: September 2024

Abstract
Changes in vapour pressure deficit can lead to the depletion and replenishment of stem water pools to buffer water potential variations in the xylem. Yet, the precise velocity at which stem water pools track environmental cues remains poorly explored. Nine eucalyptus seedlings grown in a glasshouse experienced high-frequency environmental oscillations and their stem radial variations (ΔR) were monitored at a 30-s temporal resolution in upper and lower stem locations and on the bark and xylem. The stem ΔR response to vapour pressure deficit changes was nearly instantaneous (&lt;1 min), while temperature lagged behind stem ΔR. No temporal differences in the stem ΔR response were observed between locations. Punctual gravimetric measurements confirmed the synchrony between transpiration and stem ΔR dynamics. These results indicate (i) that stem-stored water can respond to the atmospheric evaporative demand much faster than commonly assumed and (ii) that the origin of the water released to the transpiration stream seems critical in determining time lags in stem water pool dynamics. Near-zero time lags may be explained by the high elasticity of eucalyptus woody tissues and the predominant water use from the xylem, circumventing the hydraulic radial barriers to water flow from/to the outer tissues.
Poverty and Prices: Assessing the Impact of the 2017 PPPs on the International Poverty Line and Global Poverty
Authors: Jolliffe ⓡ Dean , Mahler ⓡ Daniel Gerszon , Lakner ⓡ Christoph , Atamanov ⓡ Aziz , Tetteh-Baah Samuel Kofi 
Published: September 2024

Abstract
Purchasing power parities (PPPs) are used to estimate the international poverty line (IPL) in a common currency and account for relative price differences across countries when measuring global poverty. This paper assesses the impact of the 2017 PPPs on the nominal value of the IPL and global poverty. Updating the $1.90 IPL in 2011 PPP dollars to 2017 PPP dollars results in an IPL of $2.15—a finding that is robust to various methods. Based on an updated IPL of $2.15, the global extreme poverty rate in 2017 falls from the previously estimated 9.3 to 9.1 percent, reducing the count of people who are poor by 15 million. This is a modest change compared with previous updates of PPP data. The paper also assesses the methodological stability between the 2011 and 2017 PPPs, scrutinizes large changes at the country level, and updates alternative, complementary poverty lines with the 2017 PPPs.
Effects of Clinic-based and Telerehabilitation-based Motor Control Exercises in Individuals with Chronic Low-back Pain
Authors: Fanuscu Aybüke , Öz Müzeyyen , Özel Asliyüce Yasemin , Turhan Egemen , Ülger Özlem 
Published: September 2024

Objective:
To evaluate the effectiveness of clinic-based and telerehabilitation-based motor control exercises in individuals with chronic low-back pain 3 months posttreatment.

Methods:
Forty-two participants were randomized to either clinic-based or telerehabilitation-based groups, performing exercises 3 times weekly for 8 weeks. Assessments were conducted pre-intervention, postintervention and 1 and 3 month follow-ups. The primary outcome was pain intensity (Visual Analog Scale) for low-back pain.

Results:
Both exercise approaches were found to be similarly effective in improving pain disability, quality of life (except for emotional response, energy level, sleep, and social isolation), and pain catastrophizing at both follow-up time points. The Visual Analog Scale showed statistically significant reductions in pain from baseline at all time points in both groups (P<0.001), with effect sizes ranging from moderate to strong. Nottingham Health Profile showed significant improvements in physical activity, pain, and total score, with effect sizes ranging from moderate to strong. No statistically significant changes in spatiotemporal gait parameters were observed in either group. According to the postintervention intention-to-treat analysis, lumbar flexion range of motion showed statistically significant improvements in both groups with small effect sizes (P <0.05).

Discussion:
Telerehabilitation-based motor control exercises proved as effective as clinic-based methods in treating chronic low-back pain, offering a viable alternative tailored to individual needs and circumstances.
The Increase in Early Menarche is Associated With the Increase in Chronic Back Pain in Female Adolescents
Authors: Roman-Juan Josep , Jensen Mark P. , Miró Jordi 
Published: September 2024

Objective:
Research has shown that there has been an increase in the prevalence of chronic back pain (CBP) in adolescents, especially in female adolescents. The purpose of the current study was to test the hypothesis that the observed increase in the prevalence of early menarche in female adolescents is contributing to the increase in the prevalence of CBP over time in this population.

Methods:
Cross-sectional data from 251,390 female adolescents from 27 countries/regions were drawn from the Health Behaviour in School-aged Children questionnaire-based surveys conducted in 2002, 2006, 2010, and 2014. The Karlson-Holm-Breen method was used to examine the explanatory role of the increase in the prevalence of early menarche on the increase in the prevalence of CBP while controlling for socioeconomic status, physical activity, body mass index, and psychological symptoms.

Results:
The increase in the prevalence of early menarche between 2002 and 2014 was associated with the increase in the prevalence of CBP (P < 0.001). The percent of CBP prevalence increase accounted for by the increase in early menarche was 2.2%.

Conclusions:
The increase in the prevalence of CBP in female adolescents observed over the last decade may be explained, in part, by the decrease in the age of menarche. This finding, coupled with research showing a decline in early menarche worldwide, highlights the need to delve deeper into the underlying mechanisms of the association between early menarche and pain—particularly CBP—in female adolescents.
Distal Tibial Dome Osteotomy With Ilizarov Fixation in Correction of Ankle Deformity Resulting From Malunited Ankle Fusion
Authors: Diab Ramy A. , Abdelghaffar Khaled , Rashid Kyrillos , Gemeah Mostafa , El Ghazawy Ahmed K. 
Published: September 2024

Background:
Distal tibial osteotomy is used in the treatment of ankle deformities. Many methods of fixation of this osteotomy were described, including plates, pins, and ilizarov. Dome osteotomy is a cylindrical osteotomy with no bone loss, with the axis of bone is rotated around the center of the circle. We conducted a case series of treatment of ankle deformity due to malunited ankle fusion with distal tibial dome osteotomy.

Methods:
Eight patients with a history of poliomyelitis with ankle deformity due to a malunited ankle fusion underwent distal tibial dome osteotomy with ilizarov fixation for deformity correction. Postoperative follow up was done up to 12 months postoperatively. We intended to follow up the union of the osteotomy, the axis of the limb, the external clinical appearance, and patient satisfaction.

Results:
Deformity correction was achieved in all patients regarding the clinical alignment, with no apparent clinical residual deformity in coronal, sagittal plane, or rotational deformity, the limb was cosmetically straight with a plantigrade foot satisfactory to the patients with improving quality of gait. The osteotomy fully united in all patients in a period of 8 to 11 weeks with an average of 9.3 weeks, after which frame was removed. No patient had nonunion or delayed union of the osteotomy. Three patients had pin tract infection during the period of the fixator which was treated by local dressings and antibiotics.

Conclusion:
Distal tibial focal dome osteotomy fixed by ilizarov is an effective treatment option in malunited ankle fusion deformities.