bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRANDING KOPI TULI DALAM MEMBANGUN BRAND IDENTITY
Authors: Sungkono Nono , Hamzah Radja Erland , Toruan Rialdo Rezeky Manogari Lumban , Tryarno Adi Nur Achmad 
Published: September 2024

Branding strategy is a step to achieve goals that function in regulating all brand elements related to consumer attitudes and behavior. As in Kopi Tuli, carrying out a branding strategy with its limitations, namely the deaf disability, with the limitations that Kopi Tuli has as a deaf disability, it is possible that Kopi Tuli can carry out a branding strategy aimed at managing all brand elements, and building brand identity. This study aims to determine the branding Kopi Tuli, to determine brand identity Kopi Tuli, and to determine the branding Kopi Tuli in building a brand identity. Using the concept of branding put forward by experts, namely Brand identity, Brand positioning, Brand communication, Brand personality, and Brand equity. And to find out the identity of Kopi Tuli, Aaker's brand identity model divides brand identity into twelve dimensions into four perspectives. Besides that, to find out the branding Kopi Tuli brand identity using the research results that have been described. This study uses a qualitative descriptive method by conducting direct observations and interviews with the founders of Kopi Tuli, consumers of Kopi Tuli and advertising experts. The results showed that the branding through social media Instagram was by promoting products and learning sign language. brand identity Tuli shows that Kopi Tuli builds brand and quality products that have their own distinctive taste.strategy branding in building brand identity has communication barriers, to overcome this, the deaf coffee uses sign language through social media Instagram and events, aiming to build a deaf coffee brand identity and products.
Evaluation of prognostic risk factors of triple-negative breast cancer with 18F-FDG PET/CT parameters, clinical pathological features and biochemical indicators
Authors: Zhu Lei , Yang Xin , Zhang Jiying , Wang Shuling , Wang Yulong , Wan Xing , Zhu Xiang , Song Xiuyu , Tong Zhongsheng , Yang Meng , Zhao Weipeng 
Published: September 2024

IntroductionBreast cancer is a heterogeneous disease comprising various molecular subtypes, including Luminal A, Luminal B, human epidermal growth factor receptor-2 (HER2) positive, and triple negative types, each with distinct biological characteristics and behaviors. Triple negative breast cancer (TNBC) remains a particularly challenging subtype worldwide. Our study aims to evaluate whether Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) parameters, clinical pathological features, and biochemical indicators serve as prognostic risk factors for TNBC. Additionally, we explore correlations between biochemical indicators and 18F-FDG PET/CT parameters.MethodsWe conducted a retrospective analysis of 95 TNBC patients who underwent preoperative 18F-FDG PET/CT examinations at Tianjin Medical University Cancer Institute and Hospital from 2013 to 2018. Collected data included 18F-FDG PET/CT parameters, clinical and pathological features, and biochemical indicators. We used Kaplan-Meier survival analysis and multivariate Cox regression analysis to evaluate associations between 18F-FDG PET/CT parameters/biochemical indicators and disease free survival (DFS)/overall survival (OS). The log-rank test determined significant differences in survival curves, and the Spearman correlation coefficient analyzed correlations between quantitative variables. Visualization and analysis were performed using R packages.ResultsAmong 95 TNBC patients, mean standardized uptake value (SUVmean) was significantly correlated with DFS. Fasting blood glucose (FBG), α- L-fucosylase (AFU) and Creatine kinase (CK) were independent predictors of DFS, while Precursor albumin (PALB) and CK were independent predictors of OS. FBG showed correlations with SUVpeak and SUVmean, and CK was correlated with peak standardized uptake value (SUVpeak). Our results indicated that 18F-FDG PET/CT parameters and biochemical indicators may constitute a new prognostic model for TNBC patients post-surgery.DiscussionWe found that SUVmean, FBG, AFU and CK are predictive factors for DFS in TNBC patients post-surgery, while PALB and CK are predictive factors for OS, which prompts us to pay more attention to these indicators in clinical practice. Also 18F-FDG PET/CT parameters and biochemical indicators have potential utility in constituting a new prognostic model for TNBC patients post-surgery.
Clinical characteristics and management of functional neurological disorders (FND) mimicking stroke in emergency settings: a functional stroke mimic cases
Authors: Caruso Paola , Radin Yvonne , Mancinelli Laura , Quagliotto Magda , Lombardo Tiziana , Pavan Stefania , Catalan Mauro , Clarici Andrea , Bulfon Matteo , Benussi Alberto , Manganotti Paolo 
Published: September 2024

BackgroundFNDs mimicking a stroke represent a growing challenge in the emergency department (ED). A comprehensive diagnostic approach involving clinical evaluation and neuroimaging is essential to differentiate stroke from mimics. The safety profile of thrombolysis justifies its use where FNDs cannot be ruled out. This approach highlights the need for more precise diagnostic tools and protocols to improve patient care and reduce unnecessary treatments. Distinguishing FNDs from actual cerebrovascular events is critical yet difficult, particularly under time constraints. Given the urgency and potential severity of strokes, intravenous thrombolysis is frequently administered even when FNDs cannot be definitively excluded.MethodsThis retrospective study analyzed data of participants admitted to the Trieste University Hospital Stroke Unit between January 2018 and December 2022, focusing on those presenting with sudden-onset focal neurological deficits mimicking a stroke, with some presenting within the reperfusion treatment window (&lt;4.5 h from symptoms onset). We obtained detailed clinical evaluations and neuroimaging, and administered thrombolytic therapy in selected cases.Results and discussionWe included 84 participants presenting with stroke mimics (average age of 45 yo) predominantly female (65.5%). Most common presentations: hemiparesis or hemisensory loss (75%), speech disorder (10.7%), vertigo/gait disorders (4.8%). History of psychiatric disorders was found in 32.1% of cases, and 48.8% had prior neurological disease or stroke risk factors. Advanced neuroimaging was performed in 43 cases yielding normal or non-specific results. Thrombolysis was safely administered in 31%. Patients mostly recovered within the first 24 h from admission (44.7%). We compared this FND’s sample with 291 patients with mild ischemic stroke (NIHSS ≤7).
A review of the sources and pharmacological research of morroniside
Authors: Shi Pengliang , Zheng Bingqing , Zhang Shiyao , Guo Qingmei 
Published: September 2024

IntroductionMorroniside (Mor) is a bioactive compound found in Corni Fructus (CF) [Cornaceae; Cornus officinalis Siebold &amp; Zucc.], which has been used as medicine and food in China, Korea, and Japan for over 2,000 years. This review summarizes recent progress on Mor, specifically focusing on its distribution, isolation, detection, and various pharmacological effects.MethodsA literature survey on Mor was conducted using electronic databases such as PubMed, ScienceDirect, CNKI, and Google Scholar. After removing TCM prescription-related standards, medicinal herb processing-related research, and other irrelevant works of literature, we obtained relevant information on Mor’s biological and pharmacological properties.ResultsThe main conclusions are as follows: Mor is widely distributed in the plant kingdom; the methods for extracting and isolating Mor are well established; and the technology for detecting it is accurate. Mor exhibits numerous pharmacological effects. Along with CF, Mor has shown renoprotective effects against diabetes, hepatoprotective effects against diabetes, triptolide, and nonalcoholic steatohepatitis, and boneprotective effects against osteoporosis and osteoarthritis. In addition, researchers have also explored other pharmacological effects of Mor, including neuroprotective effects against focal cerebral ischemia, spinal cord injury, and Alzheimer’s disease; cardioprotective effects against acute myocardial infarction; protection of the digestive system from gastritis, inflammatory bowel disease, and colitis; protection of the skin by promoting hair growth, wound healing, and flap survival; and protection of the lungs from acute lung injury and pulmonary fibrosis. Moreover, Mor has anti-obesity effects, anti-inflammatory effects in the eye, and improves follicular development.DiscussionOverall, this review provides a comprehensive understanding of the pharmacological effects of Mor, from which the limitations of the current research can be understood, which will help facilitate future research.
A discovery and verification approach to pharmacovigilance using electronic healthcare data
Authors: Dijkstra Louis , Schink Tania , Linder Roland , Schwaninger Markus , Pigeot Iris , Wright Marvin N. , Foraita Ronja 
Published: September 2024

IntroductionPharmacovigilance is vital for drug safety. The process typically involves two key steps: initial signal generation from spontaneous reporting systems (SRSs) and subsequent expert review to assess the signals’ (potential) causality and decide on the appropriate action.MethodsWe propose a novel discovery and verification approach to pharmacovigilance based on electronic healthcare data. We enhance the signal detection phase by introducing an ensemble of methods which generated signals are combined using Borda count ranking; a method designed to emphasize consensus. Ensemble methods tend to perform better when data is noisy and leverage the strengths of individual classifiers, while trying to mitigate some of their limitations. Additionally, we offer the committee of medical experts with the option to perform an in-depth investigation of selected signals through tailored pharmacoepidemiological studies to evaluate their plausibility or spuriousness. To illustrate our approach, we utilize data from the German Pharmacoepidemiological Research Database, focusing on drug reactions to the direct oral anticoagulant rivaroxaban.ResultsIn this example, the ensemble method is built upon the Bayesian confidence propagation neural network, longitudinal Gamma Poisson shrinker, penalized regression and random forests. We also conduct a pharmacoepidemiological verification study in the form of a nested active comparator case-control study, involving patients diagnosed with atrial fibrillation who initiated anticoagulant treatment between 2011 and 2017.DiscussionThe case study reveals our ability to detect known adverse drug reactions and discover new signals. Importantly, the ensemble method is computationally efficient. Hasty false conclusions can be avoided by a verification study, which is, however, time-consuming to carry out. We provide an online tool for easy application: https://borda.bips.eu.
STA-9090 in combination with a statin exerts enhanced protective effects in rats fed a high-fat diet and exposed to diethylnitrosamine and thioacetamide
Authors: Abdelhamid Amir Mohamed , Saber Sameh , Hamad Rabab S. , Abdel-Reheim Mustafa Ahmed , Ellethy Abousree T. , Amer Maha M. , Abdel-Hamed Mohamed R. , Mohamed Enas A. , Ahmed Syed Suhail , Elsisi Hossam A. , Khodeir Mostafa M. , Alkhamiss Abdullah S. , A. AlSalloom A. , Abu Elgasim Mawahib Ahmed Elawad , Almansour Zainab H. , Elesawy Basem H. , Elmorsy Elsayed A. 
Published: September 2024

IntroductionLiver fibrosis is a significant global health burden that lacks effective therapies. It can progress to cirrhosis and hepatocellular carcinoma (HCC). Aberrant hedgehog pathway activation is a key driver of fibrogenesis and cancer, making hedgehog inhibitors potential antifibrotic and anticancer agents.MethodsWe evaluated simvastatin and STA-9090, alone and combined, in rats fed a high-fat diet (HFD) and exposed to diethylnitrosamine and thioacetamide (DENA/TAA). Simvastatin inhibits HMG-CoA reductase, depleting cellular cholesterol required for Sonic hedgehog (Shh) modification and signaling. STA-9090 directly inhibits HSP90 chaperone interactions essential for Shh function. We hypothesized combining these drugs may provide liver protective effects through complementary targeting of the hedgehog pathway. Endpoints assessed included liver function tests, oxidative stress markers, histopathology, extracellular matrix proteins, inflammatory cytokines, and hedgehog signaling components.ResultsHFD and DENA/TAA caused aberrant hedgehog activation, contributing to fibrotic alterations with elevated liver enzymes, oxidative stress, dyslipidemia, inflammation, and collagen deposition. Monotherapies with simvastatin or STA-9090 improved these parameters, while the combination treatment provided further enhancements, including improved survival, near-normal liver histology, and compelling hedgehog pathway suppression.DiscussionOur findings demonstrate the enhanced protective potential of combined HMG CoA reductase and HSP90 inhibition in rats fed a HFD and exposed to DENA and TAA. This preclinical study could help translate hedgehog-targeted therapies to clinical evaluation for treating this major unmet need.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may reduce the risk of developing cancer-related lymphedema following axillary lymph node dissection (ALND)
Authors: Brown Stav , Tadros Audree B. , Montagna Giacomo , Bell Tajah , Crowley Fionnuala , Gallagher Emily J. , Dayan Joseph H. 
Published: September 2024

PurposePatients undergoing axillary lymph node dissection (ALND) for breast cancer face a high risk of lymphedema, further increased by high body mass index (BMI) and insulin resistance. GLP-1 receptor agonists (GLP-1RAs) have the potential to reduce these risk factors, but their role in lymphedema has never been investigated. The purpose of this study was to determine if GLP-RAs can reduce the risk of lymphedema in patients undergoing ALND.MethodsAll patients who underwent ALND at a tertiary cancer center between 2010 and 2023 were reviewed. Patients with less than 2 years of follow-up from the time of ALND were excluded. Race, BMI, radiation, chemotherapy history, pre-existing diagnosis of diabetes, lymphedema development after ALND, and the use of GLP-1RAs were analyzed. Multivariate logistic regression analysis was performed to assess if there was a significant reduction in the risk of developing lymphedema after ALND. A sub-group analysis of non-diabetic patients was also performed.Results3,830 patients who underwent ALND were included, 76 of which were treated with. GLP-1 RAs. The incidence of lymphedema in the GLP-1 RA cohort was 6.6% (5 patients). Compared to 28.5% (1,071 patients) in the non-GLP-1 RA cohort. On multivariate regression analysis, patients who were treated with GLP-1 RA were 86% less likely to develop lymphedema compared to the non-GLP-1 RA cohort (OR 0.14, 95% CI 0.04–0.32, p &lt; 0.0001). A BMI of 25 kg/m 2 or greater was a statistically significant risk factor for developing lymphedema with an odds ratio of 1.34 (95% CI 1.16–1.56, p &lt; 0.0001). Diabetes was associated with lymphedema development that closely approached statistical significance (OR 1.32, 95% CI 0.97–1.78, p = 0.06). A subgroup analysis solely on non-diabetic patients showed similar results. The odds of developing lymphedema were 84% lower for patients without diabetes treated with GLP1-RAs compared to those who did not receive GLP-1 RAs (OR 0.16, 95% CI 0.05–0.40, p &lt; 0.0001).ConclusionGLP1-RAs appear to significantly reduce the risk of lymphedema in patientsundergoing ALND. The mechanism of action may be multifactorial and not limited to weight reduction and insulin resistance. Future prospective analysis is warranted to clarify the role of GLP-1RAs in reducing lymphedema risk.
The efficacy of psychodynamic psychotherapy for young adults: a systematic review and meta-analysis
Authors: Trotta Antonella , Gerber Andrew J. , Rost Felicitas , Robertson Sarah , Shmueli Avi , Perelberg Rosine J. 
Published: September 2024

ObjectiveOne in six young adults presents with at least one mental health problem. However, so far, little attention has been directed to the mental health needs and the efficacy of therapeutic interventions for young adults. We conducted a systematic review and meta-analysis of the type, quality and efficacy of psychoanalytic psychotherapy for young people.MethodWe searched the PsycInfo, PubMed, Embase, and Cochrane databases to identify all the published randomized controlled trials (RCT), and naturalistic and observational studies of psychodynamic or psychoanalytic psychotherapies. We calculated the standardized mean difference in scores of psychodynamic interventions versus control conditions, adopting a random effects model (Hedges’ g).ResultsWe identified 22 eligible studies, including 14 RCTs, and 8 naturalistic studies. Statistical analyses showed no significant difference between psychodynamic psychotherapy and other comparison treatments (psychotherapy or pharmacological interventions) for young adults (Hedges’g − 0.34 [95% CI: −0.991;-0.309], p = 0.304). Nevertheless, there was a significant effect of psychodynamic psychotherapy when compared with control conditions (waiting list or treatment as usual) for target symptoms (Hedges’g − 1.24 [95% CI: −1.97;-0.51], p &lt; 0.001).ConclusionOur systematic review highlights important clinical implications in identifying the efficacy of psychoanalytic interventions for specific at-risk groups and suggests developing prevention strategies for mental health problems in young adulthood across cultures and context.
Dual trajectories of social participation and frailty in Chinese older adults: a longitudinal study based on CLHLS from 2008 to 2018
Authors: Bi Yiyun , Hu Jing , Ma Yilei , Yin Ping , Wang Peng 
Published: September 2024

IntroductionThis study aimed to identify the dual trajectories of social participation (SP) and frailty index (FI) among Chinese older adults, and investigate common influential factors of both trajectories.MethodsUtilizing data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2008–2018 surveys, 1,645 individuals were analyzed. A group-based dual trajectory model and logistic regression were used to examine trajectories, their interrelations and shared influencing factors.ResultsThis study identified three SP, two FI trajectories and six distinct sub-groups of individuals. The study confirmed a long-term, interrelated relationship between two outcomes and identified some common factors. Compared to participants in the lower SP trajectory, those who followed the middle SP trajectory and higher SP trajectory had increased probabilities of belonging to the slow-growth FI trajectory (90.28 and 99.71%, respectively). And the participants in the slow-growth FI exhibited higher probabilities of belonging to the middle SP and the higher SP trajectory (37.64 and 25.34% higher, respectively) compared with those in the rapid-growth FI trajectory. Age, marital status, and drinking status were mutual factors associated with the dual trajectories.DiscussionThe results showed significant associations between higher levels of frailty and lower levels of social participation. Related intervention policies should consider the dual trajectories and the common factors that underlie these trajectories of SP and FI.
Effects of website-based risk communication of radio-frequency electromagnetic fields on general public
Authors: Yamaguchi-Sekino Sachiko , Kamegai Kazuhisa , Ikuyo Miwa , Taki Masao , Onishi Teruo , Watanabe Soichi 
Published: September 2024

BackgroundRadio-frequency electromagnetic fields (RF-EMFs) are utilized in communications and appliances and are indispensable in daily life. However, some people have concerns about the adverse health effects of RF-EMFs; therefore, effective risk communication (RC) is needed in this field.ObjectiveIn this study, we investigate public attitudes towards RF-EMFs and examine the impact of RC via a website on these attitudes and objective knowledge.MethodsThree web surveys were conducted over 10 weeks with the same participants. The questionnaires were conducted at three different time points with 5-week intervals: baseline survey (T1), RC evaluation survey (T2), and follow-up survey (T3). Participants of T2 were randomly recruited from among those of T1, and participants of T3 were randomly selected from among the T2 respondents. Approximately half of the respondents in each of T2 and T3 were assigned to the control group. Twelve items regarding attitudes toward RF-EMFs and objective knowledge were evaluated in all surveys (T1–T3). After removing low-engagement data, the number of valid answers was 782 in T3. Differences between T1 and T2 (Sub T1-T2) and T1 and T3 (Sub T1-T3) were analyzed. Participant selection was randomized and the authors were blind to this selection until analysis.ResultsFour clusters were identified: Cluster 1 (Non-anxious, 25.0%), Cluster 2 (Anxious, 16.0%), Cluster 3 (Low-interest, 40.5%), and Cluster 4 (High-interest, 18.5%). A decrease in subjective RF-EMF exposure levels was noted in Cluster 2 immediately after website viewing. Temporary increases and decreases in health concerns about RF-EMF usage activities were observed in Clusters 1 and 2, respectively, immediately after viewing. Clusters 1 and 3 showed a temporal decrease in needs for RF-EMF usage activities at T2 but it returned to the baseline level 5 weeks later. Cluster 4 was less responsive to the risk communication. Subanalysis stratified by gender and age showed fluctuations in responses, especially in Clusters 1 and 2.ConclusionWe demonstrate the effectiveness of RF-EMF risk communication via websites, particularly for Cluster 2. The results of this study showed that offering objective and comprehensible information through a website can significantly reduce concerns and perceived risks related to RF-EMFs.
Menopausa: impactos na vida feminina e as alterações hormonais
Authors: Ferreira Fernanda Mendes , Rocha Marcela Dias , Estanislau Isadora Caroline Ribeiro , Melo Ana Carolina de Almeida , Silva Marianne Romagnoli 
Published: September 2024

A menopausa, definida como a cessação definitiva da menstruação após 12 meses de amenorreia, é um processo biológico natural que marca o fim do período reprodutivo da mulher. O climatério, fase de transição que antecede a menopausa, é caracterizado por uma série de sintomas devido às flutuações hormonais, como ondas de calor, atrofia vaginal, distúrbios do sono, e mudanças de humor, os quais podem impactar significativamente a qualidade de vida. O estudo tem como objetivo explorar as estratégias para minimizar os impactos das alterações hormonais durante a menopausa, focando na terapia hormonal (TH) e outras intervenções que possam melhorar a saúde e o bem-estar das mulheres nessa f0ase. A pesquisa foi realizada por meio de uma revisão bibliográfica descritiva, abrangendo artigos publicados entre 2020 e 2024 em bases de dados como Google Acadêmico, SciElo e BVS. Foram utilizados descritores como "Menopausa", "Alterações hormonais" e "Saúde da mulher", seguindo critérios de inclusão como o período de publicação e o idioma português. Os resultados destacam a complexidade da menopausa e a necessidade de abordagens personalizadas para o manejo dos sintomas e riscos associados. O estudo conclui que é crucial oferecer cuidados individualizados para mulheres durante a menopausa, utilizando terapia hormonal e outras intervenções terapêuticas para minimizar os sintomas e melhorar a qualidade de vida. A necessidade de um acompanhamento médico contínuo é enfatizada para garantir a segurança e a eficácia dos tratamentos, adaptando-os às necessidades específicas de cada mulher.