bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with performing urgent coronary angiography in out‐of‐hospital cardiac arrest patients
Authors: Lam David H. , Glassmoyer Lauren M. , Strom Jordan B. , Davis Roger B. , McCabe James M. , Cutlip Donald E. , Donnino Michael W. , Cocchi Michael N. , Pinto Duane S. 
Published: August 2017

AbstractObjectivesFactors associated with performing urgent coronary angiography (UCA) in patients with out‐of‐hospital cardiac arrest (OHCA) were identified.BackgroundCurrent guidelines for resuscitated OHCA patients recommend UCA if there is ST‐elevation on post‐arrest electrocardiogram or high suspicion of acute myocardial infarction. Some have advocated for UCA in all OHCA regardless of suspected etiology. The reasons for variations in performing UCA are not well understood.MethodsA retrospective analysis of subjects presenting with resuscitated OHCA to a single academic medical center from 12/15/2007 to 8/31/2014 was conducted. Demographic and clinical characteristics of patients undergoing UCA, defined as angiography within 6 hr of presentation, were compared with those not undergoing UCA. Logistic regression was used to determine predictors of UCA.ResultsA total of 323 resuscitated OHCA patients (mean age, 64 years; women, 35%) were included in the analysis; 107 (33.1%) underwent coronary angiography during their hospitalization and 66 (20.4%) underwent UCA. Multivariable adjusted factors associated with UCA were ST‐elevation [odds ratio (OR) 14.66, 95% confidence interval (CI) 6.28–34.24, P < 0.001], initial shockable rhythm (OR 3.69, 95% CI 1.52–8.97, P = 0.004), and history of coronary artery disease (CAD) (OR 3.37, 95% CI 1.43–7.95, P = 0.005). Higher age (OR 0.71 per decade, 95% CI 0.55–0.92, P = 0.01) and obvious non‐cardiac cause of arrest (OR 0.08, 95% CI 0.02–0.38, P = 0.001) were negatively associated with UCA.ConclusionsIn resuscitated out‐of‐hospital cardiac arrest patients, ST‐elevation, shockable rhythm, and history of CAD were associated with performing urgent coronary angiography; older patients and those with obvious non‐cardiac causes of arrest were negatively associated.
Transseptal puncture using surgical electrocautery in children and adults with and without complex congenital heart disease
Authors: Gowda Srinath T. , Qureshi Athar M. , Turner Daniel , Madan Nitin , Weigand Justin , Lorber Richard , Singh Harinder R. 
Published: August 2017

AbstractBackgroundAtrial transseptal puncture (TSP) for cardiac catheterization procedures remain challenging in children and adults with complex congenital heart disease (CHD).ObjectivesWe sought to evaluate our experience using radiofrequency (RF) current via surgical electrocautery needle for TSP to facilitate diagnostic and interventional procedures.MethodsRetrospective chart review of all patients (pts) who underwent TSP using RF energy (10–25 W) via surgical electrocautery from three centers from January 2011 to January 2017 were evaluated. Echocardiograms were reviewed to define the atrial septum as normal and complex (thin aneurysmal, thick/fibrotic, synthetic patch material, and extra cardiac conduit).ResultsA total of 54 pts underwent 55 successful TSP. Median age was 12.5 years (1 day–54 years) and weight was 52.7 kg (2–162). Indications for TSP included; EP study and ablation procedures in structurally normal hearts (n = 24) and in complex atrial septum/CHD and structural heart disease pts (n = 30): Electrophysiology study and ablation in 4, diagnostic catheterization in 9, and interventional procedures in 17 pts were performed. Atrial TSP was successful in 54/55 (98%). Atrial perforation with tiny‐small pericardial effusion not requiring intervention was noted in 2 pts. TSP was unsuccessful in one critically ill neonate with unobstructed TAPVR and restricted atrial septum who experienced cardiac arrest requiring CPR, ECMO, and emergent surgery.ConclusionsRF current delivery using surgical electrocautery for TSP is a feasible and an effective option in patients with complex CHD for diagnostic, interventional, and electrophysiology procedures.
Simulation‐based education leads to decreased use of fluoroscopy in diagnostic coronary angiography
Authors: Prenner Stuart B. , Wayne Diane B. , Sweis Ranya N. , Cohen Elaine R. , Feinglass Joe M. , Schimmel Daniel R. 
Published: August 2017

AbstractObjectivesThe aim of this study is to determine whether simulation‐based education (SBE) translates into reduced procedure time, radiation, and contrast use in actual clinical care.BackgroundAs a high volume procedure often performed by novice cardiology fellows, diagnostic coronary angiography represents an excellent target for SBE. Reports of SBE in interventional cardiology are limited and there is little understanding of the potential downstream clinical impact of these interventions.MethodsAll diagnostic coronary angiograms performed at a single center between January 1, 2011 and June 30, 2015 were analyzed. Random effects linear regression models were used to compare outcomes between procedures performed by 12 cardiology fellows who underwent simulation‐based training and those performed by 20 traditionally trained fellows.ResultsThirty‐two cardiology fellows performed 2,783 diagnostic coronary angiograms. Procedures performed by fellows trained with SBE were shorter (mean of 23.98 min vs. 24.94 min, P = 0.034) and were performed with decreased radiation (mean of 56,348 mGycm2 vs. 66,120 mGycm2, P < 0.001). After controlling for year in training, procedure year, access site, and supervising attending physician, training on the simulator was independently associated with 117 fewer seconds of fluoroscopy time per procedure (P = 0.04).ConclusionsDiagnostic coronary angiography SBE is associated with decreased use of fluoroscopy in downstream clinical care. SBE may be a useful tool to reduce radiation exposure in the cardiac catheterization laboratory
First reported case of magnesium‐made bioresorbable scaffold to treat spontaneous left anterior descending coronary artery dissection
Authors: Quadri Giorgio , Tomassini Francesco , Cerrato Enrico , Varbella Ferdinando 
Published: August 2017

AbstractSpontaneous coronary artery dissection (SCAD) is a rare cause of Acute Coronary Syndrome. Although its treatment is still debated, use of Bioreasorbable Scaffold was recently advocated as an attractive option in this setting. We report the first case, to our knowledge, of a new magnesium‐made Bioresorbable Scaffold implantation in a young woman presenting with Non‐ST‐ Elevation Myocardial Infarction and a rapid worsening SCAD.
Design and Synthesis of Chiral Diene Ligands for RhI‐Catalyzed Enantioselective Arylation of N‐DPP‐protected Aldimines: Synthesis of the Antifungal Agent Bifonazole
Authors: Syu Jin‐Fong , Lin Huang‐Ying , Cheng Yu‐Yi , Tsai Yao‐Chu , Ting Yi‐Ching , Kuo Ting‐Shen , Janmanchi Damodar , Wu Ping‐Yu , Henschke Julian P. , Wu Hsyueh‐Liang 
Published: August 2017

AbstractHerein we describe the design and synthesis of a novel family of bifunctional, chiral bicyclo[2.2.1]heptadiene ligands bearing aryl and secondary amido groups, and demonstrate their usefulness in the RhI‐catalyzed enantioselective addition reaction of arylboronic acids to N‐diphenylphosphinyl (N‐DPP)‐protected aldimines. Unlike the analogous RhI‐catalysts comprising diene ligands substituted with aryl and carboxylic ester groups, or only with aryl groups, the addition reaction proceeded with high stereoselectivity. The protocol tolerated a range of N‐DPP‐aldimines and arylboronic acids, producing the desired optically active N‐DPP‐protected amines with yields between 31–99 % and with ee values up to 91–99 %. The synthetic utility of the method was demonstrated by the conversion of N‐DPP‐protected amine 3 ae into the antifungal agent, bifonazole (13).
Efficient and Selective N‐Methylation of Nitroarenes under Mild Reaction Conditions
Authors: Pedrajas Elena , Sorribes Iván , Guillamón Eva , Junge Kathrin , Beller Matthias , Llusar Rosa 
Published: August 2017

AbstractHerein, we report a straightforward protocol for the preparation of N,N‐dimethylated amines from readily available nitro starting materials using formic acid as a renewable C1 source and silanes as reducing agents. This tandem process is efficiently accomplished in the presence of a cubane‐type Mo3PtS4 catalyst. For the preparation of the novel [Mo3Pt(PPh3)S4Cl3(dmen)3]+ (3+) (dmen: N,N′‐dimethylethylenediamine) compound we have followed a [3+1] building block strategy starting from the trinuclear [Mo3S4Cl3(dmen)3]+ (1+) and Pt(PPh3)4 (2) complexes. The heterobimetallic 3+ cation preserves the main structural features of its 1+ cluster precursor. Interestingly, this catalytic protocol operates at room temperature with high chemoselectivity when the 3+ catalyst co‐exists with its trinuclear 1+ precursor. N‐heterocyclic arenes, double bonds, ketones, cyanides and ester functional groups are well retained after N‐methylation of the corresponding functionalized nitroarenes. In addition, benzylic‐type as well as aliphatic nitro compounds can also be methylated following this protocol.
Redox Active Metal– and Covalent Organic Frameworks for Energy Storage: Balancing Porosity and Electrical Conductivity
Authors: Zhang Yugen , Riduan Siti Nurhanna , Wang Jinquan 
Published: August 2017

AbstractPorous redox‐active metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) have emerged as electrode materials for energy storage devices. These porous frameworks have different levels of intrinsic properties such as low solubility, high ionic conductivity (porosity) and low electrical conductivity, all of which are critical parameters when utilised as electrode materials. This Minireview focuses on recent developments of using porous MOFs/COFs as redox active electrode materials for energy storage and strategies to improve their electrochemical performance.
Spatial and Lateral Control of Functionality by Rigid Molecular Platforms
Authors: Valášek Michal , Mayor Marcel 
Published: August 2017

AbstractSurface mounted molecular devices have received significant attention in the scientific community because of their unique ability to construct functional materials. The key involves the platform on which the molecular device works on solid substrates, such as in solid–liquid or solid–vacuum interfaces. Here, we outline the concept of rigid molecular platforms to immobilize active functionality atop flat surfaces in a controllable manner. Most of these (multipodal) platforms have at least three anchoring groups to control the spatial arrangement of the protruding functional moieties and form mechanically stable and electronically tuned contacts to the underlying substrate. Another approach is based on employing of flat aromatic scaffolds bearing perpendicular functionalities that form stable lateral assemblies on various surfaces. Emphasis is placed on the need for controllable assembly and separation of these tailor‐made molecules that expose functionalities at the molecular scale. The discussions are focused on the different molecular designs realizing functional 3D architectures on surfaces, the role of various anchoring strategies to control the spatial arrangement, and structural considerations controlling physical features like the coupling to the surface or the available space for sterically demanding molecular operations.
Quantum Chemical Analyses of BH4− and BH3OH− Hydride Transfers to CO2 in Aqueous Solution with Potentials of Mean Force
Authors: Groenenboom Mitchell C. , Keith John A. 
Published: August 2017

AbstractBiomimetic hydride transfer catalysts are a promising route to efficiently convert CO2 into more useful products, but a lack of understanding about their atomic‐scale reaction mechanisms slows their development. To this end, we report a computational quantum chemistry study of how aqueous solvation influences CO2 reduction reactions facilitated by sodium borohydride (NaBH4) and a partially oxidized derivative (NaBH3OH). This work compares 0 K reaction barriers from nudged elastic band calculations to free‐energy barriers obtained at 300 K using potentials of mean force from umbrella sampling simulations. We show that explicitly treating free energies from reaction pathway sampling has anywhere from a small to a large effect on the reaction‐energy profiles for aqueous‐phase hydride transfers to CO2. Sampling along predefined reaction coordinates is thus recommended when it is computationally feasible.
Intermediate‐Valence Intermetallic Phase YbIn1–xAu1+x (x = 0‐0.3)†
Authors: Grin Yuri , Pöttgen Rainer , Ormeci Alim , Kremer Reinhard K. , Wagner Friedrich E. 
Published: August 2017

AbstractPolycrystalline samples YbIn1–xAu1+x were prepared by reaction of the elements in sealed tantalum tubes at 1170 K with a subsequent annealing at 770 K. The crystal structures of YbInAu (space group P6;−2m, a = 7.6992(8), c = 4.0333(5) Å, wR2 = 0.035, 282 reflections and 14 variables) and YbIn0.73Au1.27 (P6;−2m, a = 7.706(3), c = 4.011(1) pm, wR2 = 0.035, 275 reflections, 14 parameters) were refined from single crystal X‐ray diffraction data. The phase YbIn1–xAu1+x has a homogeneity range for 0.0≤x≤0.3 (770 K). The crystal structure of YbInAu contains two gold atoms located in tricapped trigonal prisms [Au1Yb6In3] and [Au2In6Yb3]. The indium position shows mixed occupancy by indium and gold. The main atomic interaction is the ionic one between the ytterbium (charge +1.1 is obtained from the analysis of the electron density within the quantum theory of atoms in molecules) and gold (−1.2 and −1.3) supported by the dative bonding Au→Yb. The effective charge of indium is +0.2. Magnetic susceptibility data indicate intermediate valence for Yb increasing with increasing x. The 197Au Mössbauer spectra show a superposition of the signals for Au1 (δ = 3.31 mm s–1), Au2 (δ = 5.37 mm s–1), and Au(In) indicating auridic character of gold.
Synergistic effects of the combined use of human‐cultured periosteal sheets and platelet‐rich fibrin on bone regeneration: An animal study
Authors: Horimizu Makoto , Kubota Takehiko , Kawase Tomoyuki , Nagata Masaki , Kobayashi Mito , Okuda Kazuhiro , Nakata Koh , Yoshie Hiromasa 
Published: August 2017

AbstractA human‐cultured alveolar bone‐derived periosteal (hCP) sheet is an osteogenic grafting material used clinically in periodontal regenerative therapy, while platelet‐rich fibrin (PRF), a platelet concentrate with fibrin clot, is considered to augment the wound healing process. Therefore, whether the combined use of hCP‐PRF complex could facilitate bone regeneration synergistically was evaluated in animal models. Human periosteal segments (1 × 1 mm) were cultured initially on plastic dishes and formed an hCP sheet. The hCP sheet was implanted with freshly prepared human PRF into subcutaneous tissue (hCP: n = 4, hCP + PRF: n = 4) and 4 mm diameter calvarial bone defect models (hCP: n = 4, hCP + PRF: n = 4, control [defect‐only]: n = 4) that prepared in nude mice. At 4 weeks postimplantation, new bone formation was evaluated by using μCT. Cell growth and neovascularization were evaluated by histochemical and immunohistological methods. In the subcutaneous tissue, mineral deposit formation, collagen deposition, and number of vessels were higher in the hCP + PRF group than in the hCP alone group. In the calvarial defect models, new bone formation was significantly higher in the hCP + PRF group than in the hCP alone group and defect‐only control group. The numbers of vessels and PCNA‐positive cells in calvarial defects were also increased in the hCP + PRF group more than in the hCP alone group. Platelet‐rich fibrin preparations support the proliferation and the growth of periosteal cells to form well‐combined active biological materials. Platelet‐rich fibrin also stimulates the local angiogenesis in the implantation site. Therefore, the combined use of hCP and PRF could be clinically applicable in bone regeneration therapy.
Energy‐efficient routing protocol to improve energy consumption in wireless sensors networks
Authors: ELkamel Rabiaa , Cherif Adnane 
Published: August 2017

SummaryThe energy consumption is considered to be the major challenge in wireless sensor networks. In this paper, we shed light on a new approach to overcome the energy consumption problems. The objective of this work is to integrate an improved algorithm which is the K‐means to create a balanced energy on clusters and to use the Gaussian elimination algorithm during the election of cluster head that will guarantee the distribution of energy consumption. To address the problem of the optimal number of groups, we use Davies Bouldin index to increase the network lifetime. The simulation result shows that the proposed protocol extends the network lifetime compared to Leach, iMod‐Leach, leach‐C, and CELRP.
Phenotypic outcomes in adolescence and adulthood in the scarcity‐adversity model of low nesting resources outside the home cage
Authors: Doherty Tiffany S. , Blaze Jennifer , Keller Samantha M. , Roth Tania L. 
Published: August 2017

AbstractEarly life adversity is known to disrupt behavioral trajectories and many rodent models have been developed to characterize these stress‐induced outcomes. One example is the scarcity‐adversity model of low nesting resources. This model employs resource scarcity (i.e., low nesting materials) to elicit adverse caregiving conditions (including maltreatment) toward rodent neonates. Our lab utilizes a version of this model wherein caregiving exposures occur outside the home cage during the first postnatal week. The aim of this study was to determine adolescent and adult phenotypic outcomes associated with this model, including assessment of depressive‐ and anxiety‐like behaviors and performance in different cognitive domains. Exposure to adverse caregiving had no effect on adolescent behavioral performance whereas exposure significantly impaired adult behavioral performance. Further, adult behavioral assays revealed substantial differences between sexes. Overall, data demonstrate the ability of repeated exposure to brief bouts of maltreatment outside the home cage in infancy to impact the development of several behavioral domains later in life.
Is laxative misuse associated with binge eating? Examination of laxative misuse among individuals seeking treatment for eating disorders
Authors: Elran‐Barak Roni , Goldschmidt Andrea B. , Crow Scott J. , Peterson Carol B. , Hill Laura , Crosby Ross D. , Mitchell James E. , Le Grange Daniel 
Published: August 2017

AbstractObjectiveOur research focuses on laxative misuse, which has been understudied in previous eating disorders (ED) research, to understand its prevalence and correlates among individuals seeking ED treatment. We also test the association between laxative misuse and binge eating to examine the assumption that laxative misuse is intended to compensate for binge eating.MethodParticipants were 2,295 ED treatment‐seeking adults (29.5 ± 10.5) who self‐reported their disordered eating behaviors on the Eating Disorder Questionnaire. Participants met DSM‐5 diagnostic criteria for anorexia nervosa (AN: 11.5%, n = 264), bulimia nervosa (BN: 39.0%, n = 896), binge‐eating disorder (14.9%, n = 343), or other specified feeding or eating disorder (34.5%, n = 792).ResultsNearly 25% of participants (n = 571) reported misusing laxatives during the last month. Laxative misusers with AN reported significantly higher frequency of laxative misuse relative to misusers with BN (F(1,440) = 5.226, p = .023,
= .012). Among laxative misusers, there was no association between frequency of binge eating and frequency of laxative misuse.DiscussionLaxative misusers with AN tend to misuse laxatives more frequently than those with BN. Binge eating was not related to laxative misuse in our sample. Future research may use real‐time data collection to understand the function of laxative misuse and to validate our cross‐sectional findings.
Functional differentiation in pollination processes among floral traits inSerapiasspecies (Orchidaceae)
Authors: Pellegrino Giuseppe , Bellusci Francesca , Palermo Anna Maria 
Published: August 2017

AbstractFloral displays, influencing attractiveness to insects, increase the number of pollinator visits and the efficiency of each visit in terms of pollen exchange and thus affect the plant reproductive success. Here, we conducted an in situ manipulation experiment to investigate whether the floral modifications affect reproductive success in natural orchid populations ofSerapias linguaandSerapias vomeracea. We estimated male and female reproductive success of three treatment groups, disassembly of floral tube, cutting of lip, and painting of the callus surface, in terms of pollinaria removed/deposited and fruit production. Results revealed that phenotypic modification had opposite effects on reproductive success of two examine species. Indeed, reproductive success was significantly increased by the detached of the petals and sepals, and decreased, due to callus painting and lip removal, inS. lingua. On the contrary, unmanipulated plants ofS. vomeraceashowed significantly higher value of pollinaria removed and deposited and fruit set than manipulated ones. The differences betweenS. linguaandS. vomeraceaagree to the different pollination strategy of examined species.S. vomeraceashows shelter imitation strategy, and thus, the disassembly of tunnel‐like corolla does not allow the insects to use the flower as a refuge, whileS. linguais a sexually deceptive orchid and therefore the opening of the flower made more visible callus (visible at a greater distance) increasing the pollinators attraction. This study provides evidence that pollinators were largely sensitive to the experimental modification of the flower phenotype, which is consistent with the presence of significant selection on individual floral characters. Our experimental investigations of the effects of variation in display on pollinator visitation provide insights into the evolution of floral morphology in orchid with shelter imitation strategy.