bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dry Eye Syndrome-Related Quality of Life in Glaucoma Patients
Authors: Rossi Gemma Caterina Maria , Tinelli Carmine , Pasinetti Gian Maria , Milano Giovanni , Bianchi Paolo Emilio 
Published: January 2018

Purpose To verify the presence of dry eye syndrome (DES) in treated patients with glaucoma and to analyze DES's impact on the patients' quality of life (QOL) versus the control group. Methods In this observational cross-sectional study, 61 patients were enrolled at a clinical practice. Patients were divided into three groups by number of glaucoma drops instilled per day (G1=1 drop/day, G2=2 drops/day, G3=3 drops/day). A control group of 20 subjects was also selected (G0). All subjects were submitted to a complete ocular examination (including tear function and ocular surface status) and completed the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), Glaucoma Symptom Scale (GSS) questionnaire, and Ocular Surface Disease Index (OSDI). DES was defined as presence of punctate keratitis and decreased break-up time. Statistical analysis was performed applying the Kruskal-Wallis analysis of variance and Mann-Whitney U tests (to compare median values between groups) as well as the χ2 and Fisher test (to verify significant differences). Results A total of 40% of G3 and 39% of G2 patients presented DES versus 11% of G1 and 5% of G0 (p=0.01). QOL was significantly influenced and altered (NEI-VFQ 25 total mean and GSS total mean and symptoms average: p=0.0085, p=0.006, and p=0.03, respectively). OSDI pointed out differences by group: 26% of G2 and 15% of G3 presented moderate OSDI and 15% of G3 and 8.7% of G2 severe OSDI (p>0.05). Conclusions Patients with topically treated glaucoma present DES more often than a similar control group (p=0.01). The presence of DES negatively influences the patient's QOL. The patients with glaucoma's ocular surface status should be evaluated regularly to ensure the timely detection and treatment of pathologic signs on the ocular surface.
Color Doppler Imaging and Ocular Pulse Amplitude in Glaucomatous and Healthy Eyes
Authors: Stalmans Ingeborg , Harris Alon , Fieuws Steffen , Zeyen Thierry , Vanbellinghen Veerle , McCranor Lynne , Siesky Brent 
Published: January 2018

Purpose To determine factors influencing color Doppler imaging (CDI) measurements, to compare retrobulbar flow velocities between patients with glaucoma and healthy controls, and to describe the correlation between CDI and ocular pulse amplitude (OPA). Methods Patients with normal tension (n=28) or primary open angle glaucoma (n=19) and healthy controls (n=22) underwent CDI and OPA measurements. Intraocular pressure, corneal thickness, blood pressure, and heart rate were also measured. Spearman correlations were used to explore relations among these variables. A regression model for repeated measures was applied to compare between diagnostic groups the flow velocity indices in the retrobulbar vessels. Results Retrobulbar diastolic blood flow velocities correlated with diastolic blood pressure and perfusion pressure (range of Spearman rho [ρ] coefficients=0.25–0.28; P=0.044–0.013 for the different vessels). Corneal thickness showed a positive correlation with systolic and diastolic flow velocities in the central retinal artery (ρ=0.29 and 0.31; P=0.017 and 0.011 for peak systolic and end diastolic velocity, respectively). Systolic and diastolic blood flow velocities were reduced in the retrobulbar vessels of patients with normal tension glaucoma (P=0.0004) as well as primary open angle glaucoma (P=0.003) compared to healthy controls. A correlation was found between OPA and the resistive index in the retrobulbar vessels of the healthy controls (range ρ=0.42–0.53; P=0.059–0.014). Conclusions Retrobulbar blood flow velocities are reduced in patients with primary open angle glaucoma and normal tension glaucoma. Blood pressure and corneal thickness may influence CDI measurements. OPA correlates with the resistive index in CDI.
Ophthalmologist Attitudes regarding Fixed Combination Treatment for Glaucoma in the European Union
Authors: Stewart William C. , Kruft Bonnie , Nelson Lindsay A. , Stewart Jeanette A. 
Published: January 2018

Purpose To survey ophthalmologists in the European Union to determine their fixed combination (FC) preferences. Methods A multiple-choice survey was sent to randomly chosen ophthalmologists throughout the European Union and bordering countries by electronic mail delivery. Ophthalmologists were resent the survey on two more occasions if no response was obtained. Results In total, 50 surveys were received from 530 distributed (9.4% response) from 16 countries. More ophthalmologists prescribed an FC as second (80%) or third choice (64%) therapy than first choice (30%, p=0.0036). As first (p<0.0001) and third choice (p=0.011), the dorzolamide/timolol FC was most commonly prescribed, while as second choice the latanoprost/timolol FC (p<0.0001) was most popular. Overall, 98% (49/50) of doctors believed FC therapy improved patient care most often by better compliance (n=49) and quality of life (n=48, p<0.0001). Most ophthalmologists believed that there was a difference in efficacy between the FC products (32/50, 64%) with the most effective being the bimatoprost/timolol FC (n=12, 24%, p=0.029). However, fewer ophthalmologists perceived safety differences between the products (34/50, 68%). For prostaglandins, dosing time was suggested in the morning by 18 (36%) ophthalmologists and in the evening by 24 (48%) (p=0.35). Conclusions FCs in the European Union are a potentially popular method to reduce intraocular pressure, being prescribed most commonly as second or third choice therapy. The perceived advantages to FC therapy are greater compliance to the medicine and improved patient quality of life.
Efficacy of Intravitreal Triamcinolone after or Concomitant with Laser Photocoagulation in Nonproliferative Diabetic Retinopathy with Macular Edema
Authors: Aydin Erdinc , Demir Helin Deniz , Yardim Huseyin , Erkorkmaz Unal 
Published: January 2018

Purpose To investigate the clinical effects and outcomes of intravitreal injection of 4 mg of triamcinolone acetonide (IVTA) after or concomitant with macular laser photocoagulation (MP) for clinically significant macular edema (CSME). Methods Forty-nine eyes of 49 patients with nonproliferative diabetic retinopathy and CSME were randomized into three groups. The eyes in the laser group (n=17), group 1, were subjected to MP 3 weeks after IVTA; the eyes in the IVTA group (n=13), group 2, were subjected to MP, concomitant with IVTA; the eyes in the control group (n=19), group 3, underwent only IVTA application. Visual acuity (VA), fundus fluorescein angiography, and photography were performed in each group. Results In the first group, the mean VA improved from 0.17±0.09 at baseline to 0.28±0.15 (p=0.114) and in the second group, deteriorated from 0.19±0.08 at baseline to 0.14±0.08 at the sixth month (p=0.141), respectively. In Group 3, the mean VA improved from 0.16±0.08 at baseline to 0.28±0.18 (p=0.118) at the end of the follow-up. When VA was compared between the control and study groups, significant difference was detected at the sixth month (p=0.038). Conclusions MP after IVTA improved VA, rather than MP concomitant with IVTA, and only IVTA application for CSME. MP after IVTA may reduce the recurrence of CSME and needs further investigations in a longer period.
Proton Beam Radiotherapy of Uveal Melanoma: Italian Patients Treated in Nice, France
Authors: Mosci Carlo , Mosci Sofia , Barla Annalisa , Squarcia Sandro , Chauvel Pierre , Iborra Nicole 
Published: January 2018

Purpose To evaluate the results of 15 years of experience with proton beam radiotherapy in the treatment of intraocular melanoma, and to determine univariate and multivariate risk factors for local failure, eye retention, and survival. Methods A total of 368 cases of intraocular melanoma were treated with proton beam radiotherapy at Centre Lacassagne Cyclotron Biomedical of Nice, France, between 1991 and 2006. Actuarial methods were used to evaluate rate of local tumor control, eye retention, and survival after proton beam radiotherapy. Cox regression models were extracted to evaluate univariate risk factors, while regularized least squares algorithm was used to have a multivariate classification model to better discriminate risk factors. Results Tumor relapse occurred in 8.4% of the eyes, with a median recurrence time of 46 months. Enucleation was performed on 11.7% of the eyes after a median time of 49 months following proton beam; out of these, 29 eyes were enucleated due to relapse and 16 due to other causes. The univariate regression analysis identified tumor height and diameter as primary risk factors for enucleation. Regularized least squares analysis demonstrated the higher effectiveness of a multivariate model of five risk factors (macula distance, optic disc distance, tumor height, maximum diameter, and age) in discriminating relapsed vs nonrelapsed patients. Conclusions This data set, which is the largest in Italy with relatively long-term follow-up, demonstrates that a high rate of tumor control, survival, and eye retention were achieved after proton beam irradiation, as in other series.
Acute Presentation of Nasal-Type Natural Killer/T-cell Lymphoma of the Orbit
Authors: Qin Wei , Yin Zhengqin , Madge Simon N. 
Published: January 2018

Purpose An unusual case of nasal-type natural killer/T-cell lymphoma (NKTL) of the orbit is reported. Methods The clinical history, computed tomography, magnetic resonance imaging, and biopsy specimen of a 29-year-old man with a right orbital lymphoma were evaluated. Results The patient initially presented with conjunctival injection and had flu-like symptoms before developing right proptosis and reduced vision; imaging showed a diffuse infiltrative process throughout the orbit. Orbital biopsy revealed angiodestruction with prominent necrosis, and angiocentric lymphoma growth and lymphoma cells were positively stained for CD3, CD20, CD45RO, CD56, cytotoxic molecules (granzyme B and T-cell intracellular antigen-1), and Epstein-Barr virus. Conclusions NKTL is rare and may present acutely; the imaging findings presented serve to highlight the radiologic features of the disease.
Palpebro-orbital Myiasis in a Patient with Basal Cell Carcinoma
Authors: Abalo-Lojo Jose M. , López-Valladares Maria J. , Llovo J. , Garcia Abel , Gonzalez Francisco 
Published: January 2018

Purpose We report a patient with basal cell carcinoma presenting with severe myiasis in a large ulcer involving the upper and lower eyelid. Methods Myiasis is an infestation of vertebrate animals by larvae of certain fly species. About 70 larvae were removed manually. A biopsy of the tissue underneath demonstrated a basal cell carcinoma. The myiasis was produced by the fly Lucilia sericata, currently used for treating chronic nonhealing ulcers. Because of the stage of the carcinoma, an orbital exenteration was carried out. Results The patient died 2 days later because of cardiopulmonary failure not related to the myiasis. Conclusions We present a case of a severe orbital myiasis focusing on its management and life-threatening nature.
Iris Color: Validation of a new Classification and Distribution in a Spanish Population-Based Sample
Authors: Díaz Yerena Muiños , Saornil Maria A. , Almaraz Ana , Muñoz-Moreno Mari F. , García Ciro , Sanz Ruperto 
Published: January 2018

Purpose To design and validate a standard, simple, and reliable iris color classification and to study its distribution in a Spanish population. Iris color has a geographic distribution and has been correlated with different ocular diseases. However, there is no standard and validated iris color classification allowing comparison among different studies. Methods Classification was made in three grades (blue-gray, hazel-green, brown) and was validated by 3 independent readers. Initially, a preliminary study was made in 50 iris photographs to detect technical hitches. Afterwards, based on this procedure, 221 iris photographs were graded Results Measures of interobserver reliability were 0.786 by kappa index with an agreement of 89.6%. Iris color distribution in the Spanish cohort was blue-grey 16.29%, hazel-green 55.2%, and brown 28.5%. Conclusions This classification is simple, reliable, and easy to use in clinical research and by ophthalmologists or generalists in practice. The Spanish cohort from this study shows a different iris color distribution from those previously published in other countries.
Leber miliary aneurysms and multiple sclerosis
Authors: Querques Giuseppe , Bux Anna V. 
Published: January 2018

Purpose To describe a patient with Leber miliary aneurysms who fulfilled the criteria for clinically definite multiple sclerosis (MS) in remission. Methods Case report. Results We performed a complete ophthalmologic examination in a 45-year-old woman who was referred to our department for retinal vascular abnormalities in her left eye. Twenty-eight years previously, the patient had been diagnosed with MS. Following a complete ophthalmologic examination, the patient was diagnosed with Leber miliary aneurysms and coincident MS in remission. To our knowledge, there are no previous reports describing association between Leber miliary aneurysms and MS. Conclusions Leber miliary aneurysms have been found in association with multiple ocular and systemic syndromes. In this report, we suggest another possible systemic association (MS) with Leber miliary aneurysms
Treatment of Serous Pigment Epithelium Detachment with Subthreshold Micropulse Diode Laser Photocoagulation: A Case Report
Authors: Battaglia-parodi Maurizio , Sheth Saumil , Papayannis Alessandro , Bandello Francesco 
Published: January 2018

Purpose To propose a possible treatment for symptomatic serous pigment epithelium detachment (SPED) in the setting of dry age-related macular degeneration. Methods A 60-year-old woman presented with a SPED, subfoveal in location, enlarging in size and with gradually worsening vision over 1 year of follow-up, without any evidence of choroidal neovascular membrane or neurosensory detachment until it was treated with subthreshold micropulse laser. Results The last follow-up showed complete resolution of the SPED with restoration of visual function. Conclusions Subthreshold micropulse laser could serve as a useful therapeutic modality for the treatment of symptomatic SPED. (Eur J Ophthalmol 2009; 19: 887–9)
Surgical Treatment in Patients with Double Elevator Palsy
Authors: Yurdakul Nazife Sefi , Ugurlu Seyda , Maden Ahmet 
Published: January 2018

Purpose To evaluate the effectiveness of surgical treatment performed in patients with double elevator palsy (DEP). Methods Patients diagnosed with congenital DEP between April 2003 and March 2007 were included in the study. The cases with positive traction test had inferior rectus (IR) recession followed by full tendon width muscle transposition Knapp surgery or partial tendon width transposition operation, while those without positive traction test underwent transposition procedure alone. Transposition surgery was combined with recession and resection of horizontal rectus muscles in patients with exotropia according to the amount of horizontal deviation. Eyelid surgery was applied in patients with ptosis following strabismus surgery. Results The average age of 13 patients was 14±32.5 years (range, 3–60 years). Five patients (38%) were female and 8 patients (62%) were male. The mean preoperative hypotropia was decreased from 29.2±3.5 prism diopters (PD) (range, 16–45 PD) to 2.6±2.8 PD (range, 0–6 PD) postoperatively. The median amount of horizontal deviation in patients with exotropia (n=4) was 30 PD (range, 25–45 PD) preoperatively; it was reduced to 2 PD (range, 0–8 PD) postoperatively. Mean follow-up period was 14.1±2.8 months (range, 6–31 months). Five patients (38%) underwent eyelid surgery, and all achieved cosmetically satisfactory results. Conclusions Transposition surgery alone or combined with IR recession is an effective procedure in treatment of double elevator palsy. In patients with moderate horizontal deviations, recession and resection of horizontal rectus muscles combined with transposition provide correction of the horizontal deviation at the same time. (Eur J Ophthalmol 2009; 19: 697–701)
Prospective Study of Risk Factors for Conjunctival Bacterial Contamination in Patients Undergoing Intraocular Surgery
Authors: De Kaspar Herminia Miño , TA Christopher N. , Froehlich Stephan J. , Schaller Ulrich C. , Engelbert Michael , Klauss Volker , Kampik Anselm 
Published: January 2018

Purpose To determine whether a patient's age, gender, local or systemic risk factors affect the rate of preoperative bacterial contamination. Methods Consecutive 1,474 patients undergoing intraocular surgery were enrolled in this prospective masked study. Past medical history was noted and examinations were performed. The patients were divided into four groups: a control group (without local or systemic risk factors), those with local risk factors (chronic use of topical medications, contact lens wear, blepharitis, chronic eyelid or conjunctival inflammation), those with systemic risk factors (immunosuppression, diabetes, autoimmune conditions, and asthma), and those with both. Conjunctival cultures were obtained before surgery. Results Among the 1,474 patients, 914 bacteria were isolated from 214 (14.9%) patients. Advanced age was associated with a higher rate of positive conjunctival cultures (p<0.005). No statistical difference was found with regard to gender (p=0.7173). Among the 282 patients in the control group, 14 (5%) had a positive conjunctival culture. Compared to the control group, positive conjunctival cultures were found in 118 out of 503 patients (23.5%) with local risk factors (p<0.0001), 65 out of 545 patients (11.9%) with systemic risk factors (p=0.0019), and 22 out of 144 (15.3%) with both (p=0.0006). Two patients developed postoperative endophthalmitis (0.14%), one with both local risk and systemic factors and the other with a systemic risk factor. Conclusions Patients with local or systemic risk factors or advanced age were found to have a higher rate of bacterial conjunctival contamination before intraocular surgery. (Eur J Ophthalmol 2009; 19: 717–22)
Usefulness of Anterior Segment Optical Coherence Tomography in Descemet Membrane Detachment
Authors: Wylęgała E. , Nowińska A. 
Published: January 2018

Purpose To evaluate the usefulness of anterior segment optical coherence tomography (OCT) in diagnosis, choosing the treatment method, and monitoring the treatment outcomes in Descemet membrane detachment (DMD). Methods We retrospectively reviewed the clinical data for 14 eyes of 13 patients: 8 eyes with DMD after cataract surgery, 2 eyes after deep anterior lamellar keratoplasty (DALK), 2 eyes of 1 patient with Ehlers-Danlos type VI syndrome, 1 eye after contusion, and 1 eye with spontaneous corneal edema of unknown origin. We used OCT to confirm or make the diagnosis, evaluate the configuration of detachment, and monitor treatment results. Results DMD was diagnosed in 12 eyes, based on the slit lamp examination. In 2 eyes, because of a very hazy view due to corneal edema, DMD was diagnosed based on OCT findings. We chose the treatment method based on DMD configuration evaluated by OCT examination. Eight eyes were treated conservatively and 6 eyes underwent intracameral air injection with additional ab externo stab incisions. In 12 eyes, Descemet membrane reattached successfully. In 2 eyes of 1 patient with Ehlers-Danlos syndrome, the detachment remained, but corneal thickness had decreased. After anterior chamber air tamponade, we observed the decrease of corneal thickness within 7 days. Conclusions OCT is useful in precise evaluation of DMD configuration and choosing the treatment method, but has a very limited role in diagnosis and monitoring the treatment results, where the clinical examination is the most important indicating factor. (Eur J Ophthalmol 2009; 19: 723–8)
Treatment of Primary Pterygium: Role of Limbal Stem Cells and Conjunctival Autograft Transplantation
Authors: Soliman Mahdy Mohamed A.E. , Bhatia Jagdish 
Published: January 2018

Purpose The limbus and its stem cells are important in the pathogenesis of pterygium. In this study, the usefulness of limbal stem cells and conjunctival autograft transplantation for the treatment of primary pterygium is assessed. Methods In this prospective noncomparative cohort study, 42 eyes of 42 patients with grade I–III primary pterygium underwent pterygium excision followed by superotemporal limbal stem cells and conjunctival autograft transplantation. Pterygium recurrences and complications within a mean follow-up period of 18.26 months (range, 10–28 months) were assessed. Results There were no recurrences of pterygium growth except in 2 cases (4.75%). In addition, no significant complications were noted. No further surgical interventions were needed in any case except for reoperation in the 2 recurrent cases. Conclusions Although limbal stem cells and conjunctival autograft transplantation is a time-consuming procedure, it is a safe and effective technique for the treatment of different grades of pterygium. It is useful in prevention of pterygium recurrence, which is a major problem in pterygium surgery. (Eur J Ophthalmol 2009; 19: 729–32)
Refractive and Visual Results after Implantation of the AcrySof ReSTOR IOL in High and Low Hyperopic Eyes
Authors: Alfonso José F. , Fernández-Vega Luis , Ortí Susana , Ferrer-Blasco Teresa , Montés-Micó Robert 
Published: January 2018

Purpose To assess the differences in refractive and visual results obtained in eyes with high and low hyperopia after implantation of a multifocal intraocular lens (IOL). Methods A prospective study was performed on 172 hyperopic eyes implanted with the AcrySof ReSTOR Natural (SN60D3) IOL. Two groups were created, high and low hyperopes (86 eyes in both cases). We analyzed monocular visual acuity for distance and near, with and without distance correction. Photopic and mesopic contrast sensitivity (CS) were also assessed. All measurements were performed at 6 months after surgery. Results Monocular best distance-corrected visual acuity was 0.01±0.03 logMAR for low hyperopes and 0.04±0.10 logMAR for high hyperopes. Monocular best distance-corrected near visual acuity was 0.02±0.04 and 0.05±0.06 logMAR for low and high hyperopes, respectively. CS for high hyperopic eyes under photopic conditions was lower, primarily at high spatial frequencies, in relation to low hyperopic eyes. Differences between both groups were statistically significant for all spatial frequencies (p<0.004). At the mesopic level, high hyperopic eyes showed lower values compared to low hyperopic eyes for all spatial frequencies. However, these differences were only statistically significant for 1.5, 12, and 18 cpd (p<0.002). Conclusions The visual acuity and CS for both distance and near, with and without distance correction, were statistically better in eyes with low hyperopia compared to those obtained in eyes with high levels of hyperopia. (Eur J Ophthalmol 2009; 19: 748–53)