bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the enablers of green supply chain management
Authors: Malviya Rakesh Kumar , Kant Ravi 
Published: February 2017

PurposeThe purpose of this paper is to identify and develop the relationships among the green supply chain management enablers (GSCMEs), to understand mutual influences of these GSCMEs on green supply chain management (GSCM) implementation, and to find out the driving and the dependence power of GSCMEs.Design/methodology/approachThis paper has identified 35 GSCMEs on the basis of literature review and the opinions of experts from academia and industry. A nationwide questionnaire-based survey has been conducted to rank these identified GSCMEs. The outcomes of the survey and interpretive structural modeling (ISM) methodology have been applied to evolve mutual relationships among GSCMEs, which helps to reveal the direct and indirect effects of each GSCMEs. The results of the ISM are used as an input to the fuzzy Matriced’ Impacts Croisés Multiplication Appliquéeá un Classement (MICMAC) analysis, to identify the driving and the dependence power of GSCMEs.FindingsOut of 35 GSCMEs 29 GSCMEs (mean⩾3.00) have been considered for analysis through a nationwide questionnaire-based survey on Indian automobile organizations. The integrated approach is developed, since the ISM model provides only binary relationship among GSCMEs, while fuzzy MICMAC analysis provides precise analysis related to driving and the dependence power of GSCMEs.Research limitations/implicationsThe weightage for ISM model development and fuzzy MICMAC are obtained through the judgment of few industry experts. It is the only subjective judgment and any biasing by the person who is judging might influence the final result.Practical implicationsThe study provides important guidelines for both practitioners, as well as the academicians. The practitioners need to focus on these GSCMEs more carefully during GSCM implementation. GSCM managers may strategically plan its long-term growth to meet GSCM action plan. While the academicians may be encouraged to categorize different issues, which are significant in addressing these GSCMEs.Originality/valueArrangement of GSCMEs in a hierarchy, the categorization into the driver and dependent categories, and fuzzy MICMAC are an exclusive effort in the area of GSCM implementation.
Artful interventions for workplace bullying: exploring forum theatre
Authors: Edwards Margot , Blackwood Kate Marie 
Published: February 2017

Purpose
This paper aims to explore the phenomenon of workplace bullying in response to recent calls for the development of different approaches and provide an exploration of artful approaches to intervention.

Design/methodology/approach
The paper offers a unique conceptualisation of workplace bullying and applies a phenomenological lens to the issue. A review of literature explores the potential value of artful interventions, and drawing on authors’ knowledge and experience with the targets of bullying, they design a forum theatre intervention for use in practice.

Findings
This paper argues that phenomenology offers a unique and valuable approach to understanding workplace bullying and its management. In turn, the authors propose that artful ways of engaging with workplace bullying could be an effective way of empowering workers in a “moment” of workplace bullying, and present a forum theatre workshop specifically designed for application in workplace contexts where bullying is prevalent. The three-phase workshop aims to help employees critically reflect on their current work practices and is intended for use in small group teaching.

Research limitations/implications
The long-term impact of this intervention has not been evaluated against more traditional methods of addressing this problem. Future research should evaluate the efficacy of this, and other art-based interventions, in workplace settings.

Originality/value
Workplace bullying research is predominantly conducted from a functionalist perspective, and other methods of inquiry, such as phenomenology, are rarely considered. This paper argues for artful interventions and provides an original, tailored workshop designed to empower employees to recognise and respond to bullying in the workplace.
Predictors of social entrepreneurial intention: an empirical study
Authors: Tiwari Preeti , Bhat Anil K. , Tikoria Jyoti 
Published: February 2017

PurposeThe purpose of this paper is to identify the role of cognitive styles (CgStys) and self-efficacy (SEff) in the formation of social entrepreneurial intentions (SEIs) among the students of a premier multi-campus technical university in India using the theory of planned behaviour as the research framework.Design/methodology/approachA 54-item questionnaire was responded by 550 students. The data were collected by employing a systematic random sampling method. In the total sample of the respondents, 67 per cent (n=368) were male and 33 per cent (n=182) were female and the average age of the respondents was 20 years. Structural equation modelling has been used for data analysis.FindingsThe results of the study support that the relationship between antecedents (CgStys and SEff) and SEIs was mediated by the attitude towards becoming a social entrepreneur, subjective norms and perceived behavioural control. Findings of this research study also suggest that students with high level of SEff are more inclined towards social entrepreneurial activities.Research limitations/implicationsThe study was confined to the students from a technical university, and it may not give the generalized findings for students from the non-technical stream.Practical implicationsThe finding of this research study will facilitate policy makers and educators for promoting social entrepreneurial activities at the university level. Based on the results and findings of the study, the educators may improve upon the support system to help and motivate students to opt social entrepreneurship as their career choice.Originality/valueThis is one of its kinds of research conducted in the Indian context. Findings of this research will be helpful in predicting how the intention process of Indian students is affected by their CgStys and SEff.
Measuring the people fleet: general analysis, interventions and needs
Authors: Hesketh Ian , Cooper Cary 
Published: February 2017

Purpose
The purpose of this paper is to deepen conceptual understanding of how employee wellbeing is identified and categorised in the workplace, and how management information is used to target workplace interventions.

Design/methodology/approach
This is a conceptual paper reviewing and discussing contemporary literature and practice, with a focus on themes congruent with employee needs and organisational intervention options in relation to wellbeing. This paper considers wellbeing in the context of police work in the UK, and how a framework can help those charged with leading to understand and act in the interest of both the employee and the organisation.

Findings
This paper suggests that the use of an appropriate strategic HR model, such as the General Analysis, Interventions and Needs (GAIN) pyramid (Hesketh and Rhodes, 2015), can assist organisations to develop practical categories and metrics to illustrate employee status in relation to wellbeing.

Practical implications
The arguments posed provide opportunities for practitioners to use workforce-modelling tools that assist in identifying, categorising and targeting wellbeing interventions in the workplace.

Originality/value
This paper highlights that identifying, categorising and prioritising wellbeing interventions in the workplace has hitherto received little academic attention. This paper contributes by providing a greater practical insight into what may work, which is important for leaders in all organisations, particularly those trying to maintain operational performance whilst undergoing programmes of change.
Sex difference and Allee effects shape the dynamics of sex‐structured invasions
Authors: Shaw Allison K. , Kokko Hanna , Neubert Michael G. 
Published: February 2017

Summary

The rate at which a population grows and spreads can depend on individual behaviour and interactions with others. In many species with two sexes, males and females differ in key life‐history traits (e.g. growth, survival and dispersal), which can scale up to affect population rates of growth and spread. In sexually reproducing species, the mechanics of locating mates and reproducing successfully introduce further complications for predicting the invasion speed (spread rate), as both can change nonlinearly with density.

Most models of population spread are based on one sex, or include limited aspects of sex differences. Here we ask whether and how the dynamics of finding mates interact with sex‐specific life‐history traits to influence the rate of population spread.

We present a hybrid approach for modelling invasions of populations with two sexes that links individual‐level mating behaviour (in an individual‐based model) to population‐level dynamics (in an integrodifference equation model).

We find that limiting the amount of time during which individuals can search for mates causes a demographic Allee effect which can slow, delay, or even prevent an invasion. Furthermore, any sex‐based asymmetries in life history or behaviour (skewed sex ratio, sex‐biased dispersal, and sex‐specific mating behaviours) amplify these effects. In contrast, allowing individuals to mate more than once ameliorates these effects, enabling polygynandrous populations to invade under conditions where monogamously mating populations would fail to establish.

We show that details of individuals’ mating behaviour can impact the rate of population spread. Based on our results, we propose a stricter definition of a mate‐finding Allee effect, which is not met by the commonly used minimum mating function. Our modelling approach, which links individual‐ and population‐level dynamics in a single model, may be useful for exploring other aspects of individual behaviour that are thought to impact the rate of population spread.
Molecular characterization of a new gene cluster for steroid degradation in Mycobacterium smegmatis
Authors: Fernández‐Cabezón Lorena , García‐Fernández Esther , Galán Beatriz , García José L. 
Published: February 2017

SummaryThe C‐19 steroids 4‐androstene‐3,17‐dione (AD), 1,4‐androstadiene‐3,17‐dione (ADD) or 9α‐hydroxy‐4‐androstene‐3,17‐dione (9OH‐AD), which have been postulated as intermediates of the cholesterol catabolic pathway in Mycobacterium smegmatis, cannot be used as sole carbon and energy sources by this bacterium. Only the ΔkstR mutant which constitutively expresses the genes repressed by the KstR regulator can metabolize AD and ADD with severe difficulties but still cannot metabolize 9OH‐AD, suggesting that these compounds are not true intermediates but side products of the cholesterol pathway. However, we have found that some M. smegmatis spontaneous mutants mapped in the PadR‐like regulator (MSMEG_2868) can efficiently metabolize all C‐19 steroids. We have demonstrated that the PadR mutants allow the expression of a gene cluster named C‐19+ (MSMEG_2851 to MSMEG_2901) encoding steroid degrading enzymes, that are not expressed under standard culture conditions. The C‐19+ cluster has apparently evolved independently from the upper cholesterol kstR‐regulon, but both clusters converge on the lower cholesterol kstR2‐regulon responsible for the metabolism of C and D steroid rings. Homologous C‐19+ clusters have been found only in other actinobacteria that metabolize steroids, but remarkably it is absent in Mycobacterium tuberculosis.
Low prevalence of non‐alcoholic fatty liver disease in patients with type 1 diabetes is associated with decreased subclinical cardiovascular disease
Authors: Serra‐Planas Enric , Aguilera Eva , Castro Laura , Rodríguez Raúl , Salinas Isabel , Lucas Anna , Joaquín Clara , Puig Rocio , Mauricio Dídac , Puig‐Domingo Manel 
Published: February 2017

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. The present study evaluated the prevalence of NAFLD in a cohort of type 1 diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD).MethodsOne hundred T1D patients (mean [±SD] age 39.4 ± 7.8 years, disease duration 21.7 ± 8.6 years) were included in the present cross‐sectional study. All subjects underwent abdominal ultrasonography for detection of NAFLD, carotid ultrasonography to measure the carotid intima–media thickness (CIMT) and atheroma plaques, and cardiac tomography for evaluation of the coronary artery calcium score (CACS).ResultsOf the study cohort, 12% had NAFLD and 23% had a CACS >0. The T1D subjects with NAFLD had a greater CIMT than those without NAFLD (0.65 ± 0.17 vs 0.55 ± 0.14 mm; P = 0.029), but there were no significant differences between the two groups with regard to CACS, glycemic control, or the presence of carotid plaques. Patients with high liver enzyme concentrations (>20 U/L) had a higher CIMT (0.60 ± 0.16 vs 0.54 ± 0.13; P = 0.04) and there was a higher proportion of altered CACS (17 [73.9%] vs 6 [26.1%]; P = 0.001) and detection of carotid plaques (10 [76.9%] vs 3 [23.1%]; P = 0.014) in this group.ConclusionsA low prevalence of NAFLD was found in the T1D cohort that was associated globally with a low proportion of abnormal CVD imaging markers, although these imaging parameters were worse in subjects in whom NAFLD was detected.
Gastric antral vascular ectasia in systemic sclerosis: Where do we stand?
Authors: El‐Gendy Hala , Shohdy Kyrillus S. , Maghraby Gehad G. , Abadeer Kerolos , Mahmoud Moustafa 
Published: February 2017

AbstractGastric antral vascular ectasia (GAVE) continues to be a challenge in both diagnosis and treatment. GAVE has a diverse group of associations and presumed causes, including cirrhosis, chronic renal failure and autoimmune connective tissue diseases. However, in most occasions, the management plan of GAVE itself is the same whatever the underlying disease by using Argon plasma coagulation (APC). Herein, we will discuss three cases of systemic sclerosis‐associated GAVE presenting with either acute or chronic gastrointestinal bleeding showing variable responses to APC. Anemia and telangiectasia may be the first striking presentation of systemic sclerosis (SSc). Renal artery stenosis, aortic stenosis, widespread cutaneous and mucosal telangiectasia and hypertension seem to be associated with poor prognosis and should prompt rapid intervention and careful follow‐up. Moreover, the hunt for molecular underpinnings of the broad array of vascular lesions in SSc has to include von Willebrand factor and endoglin. Eventually, we will review the recent alternatives that can be effective in SSc‐GAVE, such as band ligation, hematopoietic stem cells transplantation and immunotherapy.
Effects of 25‐hydroxyvitamin D and vitamin D‐binding protein on bone mineral density and disease activity in Malaysian patients with rheumatoid arthritis
Authors: Wong Tze Hao , Gupta Esha Das , Radhakrishnan Ammu K. , Gun Suk Chyn , Chembalingam Gandhi , Yeap Swan Sim 
Published: February 2017

AbstractAimVitamin D3 [25(OH)D] has been shown to be important in bone health and can influence rheumatoid arthritis (RA) disease activity. Vitamin D‐binding protein (VDBP) levels vary with race and may modulate ‘bioavailable’ levels of 25(OH)D. The aim of this study was to explore the relationships between 25(OH)D, VDBP and clinical factors on bone mineral density (BMD) in a group of multi‐ethnic Malaysian RA patients and healthy controls.MethodsA cross‐sectional study of 77 female RA patients and 29 controls was performed. Serum 25(OH)D was measured using the Elecsys® Vitamin D total assay. Serum VDBP was measured using a Quantikine® enzyme‐linked immunosorbent assay kit. BMD was assessed using dual‐energy X‐ray absorptiometry (DXA).ResultsOverall, mean 25(OH)D levels were 42.66 ± 21.75 nmol/L with no significant difference between RA patients and controls. 25(OH)D levels were significantly higher in Chinese, compared to Malay/Indian subjects. In RA patients, menopausal status and body mass index (BMI) were significantly associated with BMD but not 25(OH)D or RA Disease Activity Score of 28 joints (DAS28). There was no significant correlation between 25(OH)D and DAS28, even after correction for menopausal status and BMI. VDBP levels were not significantly different between the races and did not significantly correlate with BMD, 25(OH)D overall, or DAS28 in RA patients.ConclusionsIn Malaysian RA patients, menopausal status and BMI were more important influences on BMD than 25(OH)D or RA disease activity. The utility of measuring VDBP levels in this population remains uncertain.
Copy number variations in testicular maturation arrest
Authors: Halder A. , Kumar P. , Jain M. , Iyer V. K. 
Published: February 2017

SummaryTesticular maturation arrest is characterized by interruption of germ cell development and differentiation. Genetic factors play important role in the causation of human disease, including male infertility. The objective was to study copy number variations in testicular maturation arrest using single nucleotide polymorphism (SNP) microarray technique. Conventional cytogenetics, targeted fluorescence in situ hybridization (FISH) and sequence‐tagged site (STS) polymerase chain reaction (PCR) were used to confirm some of the SNP microarray findings. SNP microarray on 68 cases of testicular maturation arrest detected copy number variations (CNVs) mostly on sex chromosomes involving pseudoautosomal regions (PAR) 1, 2 and 3 as well as azoospermic factors (AZFs) besides three cases of chromosomal abnormalities (two Klinefelter syndromes and one case of dicentric Y). The AZF deletion was observed in 14 (20.6%) cases and the AZFc gain was observed in 6 (8.8%) cases. PAR 1 and 2 CNVs was observed in 5 (7.3%) cases. PAR 3 CNVs was detected in 19 cases and 2 controls. The TSPY2 gene gain (within PAR 3 CNVs) was observed in 16 cases and 1 control. CNV containing autosomal genes possibly associated with male infertility in this study was SPATA31A2‐A5 (9p12) in five cases. In this study, SNP microarray identified possible underlying aetiology in 55.9% (38/68) cases besides identifying minimal critical region of AZFc deletion as 0.51 mb (Y:24356128–24873665) involving TTY5, RBMY2FP, RBMY1F, RBMY1J, TTY6 and PRY genes. SNP microarray seems superior, sensitive, specific as well as cost‐effective method and has potential to be the first tier investigations to explore underlying genomic factors of testicular maturation arrest. The present study is an attempt to find out probable genomic factors with idiopathic testicular maturation arrest.
Factors associated with villus atrophy in symptomatic coeliac disease patients on a gluten‐free diet
Authors: Mahadev S. , Murray J. A. , Wu T.‐T. , Chandan V. S. , Torbenson M. S. , Kelly C. P. , Maki M. , Green P. H. R. , Adelman D. , Lebwohl B. 
Published: February 2017

SummaryBackgroundDuodenal injury persists in some coeliac disease patients despite gluten‐free diet, and is associated with adverse outcomes.AimTo determine the prevalence and clinical risk factors for persistent villus atrophy among symptomatic coeliac disease patients.MethodsA nested cross‐sectional analysis was performed on coeliac disease patients with self‐reported moderate or severe symptoms while following a gluten‐free diet, who underwent protocol‐mandated duodenal biopsy upon enrolment in the CeliAction clinical trial. Demographic factors, symptom type, medication use, and serology were examined to determine predictors of persistent villus atrophy.ResultsOf 1345 symptomatic patients, 511 (38%, 95% CI, 35–41%) were found to have active coeliac disease with persistent villus atrophy, defined as average villus height to crypt depth ratio ≤2.0. On multivariable analysis, older age (OR, 5.1 for ≥70 vs. 18–29 years, 95% CI, 2.5–10.4) was a risk factor while longer duration on gluten‐free diet was protective (OR, 0.37, 95% CI, 0.24–0.55 for 4–5.9 vs. 1–1.9 years). Villus atrophy was associated with use of proton‐pump inhibitors (PPIs; OR, 1.6, 95% CI, 1.1–2.3), non‐steroidal anti‐inflammatory drugs (NSAIDs; OR, 1.64, 95% CI, 1.2–2.2), and selective serotonin reuptake inhibitors (SSRIs; OR, 1.74, 95% CI, 1.2–2.5). Symptoms were not associated with villus atrophy after adjusting for covariates.ConclusionsA majority of symptomatic coeliac disease patients did not have active disease on follow‐up histology. Symptoms were poorly predictive of persistent mucosal injury. The impact of NSAIDs, PPIs, and SSRIs on mucosal healing in coeliac disease warrants further study.
A phase 2 study of simtuzumab in patients with primary, post‐polycythaemia vera or post‐essential thrombocythaemia myelofibrosis
Authors: Verstovsek Srdan , Savona Michael R. , Mesa Ruben A. , Dong Hua , Maltzman Julia D. , Sharma Shringi , Silverman Jeffrey , Oh Stephen T. , Gotlib Jason 
Published: February 2017

SummarySimtuzumab, a monoclonal antibody inhibitor of extracellular matrix enzyme lysyl oxidase‐like‐2, showed preclinical promise and was well tolerated in clinical studies. A phase 2, open‐label study of simtuzumab was conducted in patients with primary myelofibrosis (MF), post‐polycythaemia vera MF and post‐essential thrombocythaemia MF. Fifty‐four patients were randomized to receive simtuzumab alone (200 or 700 mg [n = 12 each group]) or simtuzumab (200 or 700 mg) with ruxolitinib (n = 15 each group) for 24 weeks. Simtuzumab alone or in combination with ruxolitinib showed no clinical benefit at 24 weeks. The mean serum simtuzumab trough concentrations appeared to increase dose‐proportionally between the 200‐mg and 700‐mg treatment groups. Therapy‐related serious adverse events were pyrexia, pain in extremity (both in 1 patient) and infusion reaction (in another patient). Bone marrow fibrosis (BMF) score was reduced at 24 weeks in 2 patients (16·7%) in the simtuzumab 700‐mg group, 1 (6·7%) in the simtuzumab 200‐mg + ruxolitinib group, and 2 (13·3%) in the simtuzumab 700‐mg + ruxolitinib group; similar numbers of patients had increased BMF. Simtuzumab alone or with ruxolitinib was well tolerated but did not produce clinical benefit nor consistently reduce BMF in patients with MF by 24 weeks.
Advanced stage nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents: clinical characteristics and treatment outcome – a report from the SFCE & CCLG groups
Authors: Shankar Ananth G. , Roques Gaelle , Kirkwood Amy A. , Lambilliotte Anne , Freund Katja , Leblanc Thierry , Hayward Janis , Abbou Samuel , Ramsay Alan D. , Schmitt Claudine , Gorde‐Grosjean Stephanie , Pacquement Hélène , Haouy Stephanie , Boudjemaa Sabah , Aladjidi Nathalie , Hall Georgina W. , Landman‐Parker Judith 
Published: February 2017

SummaryAdvanced stage nodular lymphocyte predominant Hodgkin lymphoma (nLPHL) is extremely rare in children and as a consequence, optimal treatment for this group of patients has not been established. Here we retrospectively evaluated the treatments and treatment outcomes of 41 of our patients from the UK and France with advanced stage nLPHL. Most patients received chemotherapy, some with the addition of the anti CD20 antibody rituximab or radiotherapy. Chemotherapy regimens were diverse and followed either classical Hodgkin lymphoma or B non‐Hodgkin lymphoma protocols. All 41 patients achieved a complete remission with first line treatment and 40 patients are alive and well in remission. Eight patients subsequently relapsed and 1 patient died of secondary cancer (9 progression‐free survival events). The median time to progression for those who progressed was 21 months (5·9–73·8). The median time since last diagnosis is 87·3 months (8·44–179·20). Thirty‐six (90%), 30 (75%) and 27 (68%) patients have been in remission for more than 12, 24 and 36 months, respectively. Overall, the use of rituximab combined with multi‐agent chemotherapy as first line treatment seems to be a reasonable therapeutic option.