bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer-related cognitive impairment in older adults
Authors: Edelstein Andrew , Pergolizzi Denise , Alici Yesne 
Published: January 2017

Purpose of review
Cancer, aging, and cognition form a complicated interface that can challenge patients, caretakers, and healthcare professionals. Although the typical aging process allows for compensatory mechanisms to help maintain daily functioning, cancer and cancer treatments can remove the fail-safes and exacerbate cognitive decline. As a result, older cancer patients can experience increased morbidity and mortality. The goal of this article is to provide additional assessment strategies, diagnostic considerations, and treatment options for providers taking care of this growing population.

Recent findings
In this review, we will discuss current areas of research with regard to epidemiology and our current understanding of cancer-related cognitive impairment in the older patient, while reinforcing the importance of the Comprehensive Geriatric Assessment in assessment, prognosis, and treatment guidance.

Summary
Although cognitive impairment in the older cancer patient may be an increasing cause of concern with several gaps in research, there are opportunities to take a methodical treatment approach.
A combined meta-barcoding and shotgun metagenomic analysis of spontaneous wine fermentation
Authors: Sternes Peter R. , Lee Danna , Kutyna Dariusz R. , Borneman Anthony R. 
Published: January 2017

ABSTRACTWine is a complex beverage, comprising hundreds of metabolites produced through the action of yeasts and bacteria in fermenting grape must. To ensure a robust and reliable fermentation, most commercial wines are produced via inoculation with commercial strains of the major wine yeast,Saccharomyces cerevisiae. However, there is a growing trend towards the use of uninoculated or “wild” fermentations, in which the yeasts and bacteria that are naturally associated with the vineyard and winery, perform the fermentation. In doing so, the varied metabolic contributions of the numerous non-Saccharomycesspecies in this microbial community are thought to impart complexity and desirable taste and aroma attributes to wild ferments in comparison to their inoculated counterparts.In order the map the microflora of spontaneous fermentation, metagenomic techniques were used to characterize and monitor the progression of fungal species in several wild fermentations. Both amplicon-based ITS phylotyping (meta-barcoding) and shotgun metagenomics were used to assess community structure. While providing a sensitive and highly accurate means of characterizing the wine microbiome, the shotgun metagenomic data also uncovered a significant over-abundance bias in the ITS phylotyping abundance estimations for the common non-Saccharomyceswine yeast genusMetschnikowia.
BGDMdocker: a Docker workflow for analysis and visualization pan-genome and biosynthetic gene clusters of bacterial
Authors: Cheng Gong , Lu Quan , Zhou Zongshan , Ma Ling , Zhang Guocai , Yilei WU , Chen Chao 
Published: January 2017

ABSTRACTMotivationAt present Docker technology has received increasing level of attention throughout the bioinformatics community. However, its implementation details have not yet been mastered by most biologists and applied widely in biological researches. In order to popularizing this technology in the bioinformatics and sufficiently use plenty of public resources of bioinformatics tools (Dockerfile and image of scommunity, officially and privately) in Docker Hub Registry and other Docker sources based on Docker, we introduced full and accurate instance of a bioinformatics workflow based on Docker to analyse and visualize pan-genome and biosynthetic gene clusters of a bacteria in this article, provided the solutions for mining bioinformatics big data from various public biology databases. You could be guided step-by-step through the workflow process from docker file to build up your own images and run an container fast creating an workflow.ResultsWe presented a BGDMdocker (bacterial genome data mining docker-based) workflow based on docker. The workflow consists of three integrated toolkits, Prokka v1.11, panX, and antiSMASH3.0. The dependencies were all written in Dockerfile, to build docker image and run container for analysing pan-genome of total 44Bacillus amyloliquefaciensstrains, which were retrieved from public? database. The pan-genome totally includes 172,432 gene, 2,306 Core gene cluster. The visualized pan-genomic data such as alignment, phylogenetic trees, maps mutations within that cluster to the branches of the tree, infers loss and gain of genes on the core-genome phylogeny for each gene cluster were presented. Besides, 997 known (MIBiG database) and 553 unknown (antiSMASH-predicted clusters and Pfam database) genes of biosynthesis gene clusters types and orthologous groups were mined in all strains. This workflow could also be used for other species pan-genome analysis and visualization. The display of visual data can completely duplicated as well as done in this paper. All result data and relevant tools and files can be downloaded from our website with no need to register. The pan-genome and biosynthetic gene clusters analysis and visualization can be fully reusable immediately in different computing platforms (Linux, Windows, Mac and deployed in the cloud), achieved cross platform deployment flexibility, rapid development integrated software package.Availability and implementationBGDMdocker is available athttp://42.96.173.25/bapgd/and the source code under GPL license is available athttps://github.com/cgwyx/debian_prokka_panx_antismash_biodocker.Contactchenggongwyx@foxmail.comSupplementary informationSupplementary data are available at biorxiv online.
Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans
Authors: Kleckner Ian R. , Zhang Jiahe , Touroutoglou Alexandra , Chanes Lorena , Xia Chenjie , Simmons W. Kyle , Quigley Karen S. , Dickerson Bradford C. , Barrett Lisa Feldman 
Published: January 2017

Abstract:Large-scale intrinsic brain systems have been identified for exteroceptive senses (e.g., sight, hearing, touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (N= 280 andN= 270) to evaluate the existence of an intrinsic allostatic/interoceptive system in the human brain. Another sample (N= 41) allowed us to evaluate the convergent validity of the hypothesized allostatic/interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include novel insights for the brain’s functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
Glutamate release is inhibitory and unnecessary for the long-term potentiation of presynaptic function
Authors: Padamsey Zahid , Tong Rudi , Emptage Nigel 
Published: January 2017

AbstractLong-term potentiation (LTP) and long-term depression (LTD) of transmitter release probability (Pr) are thought to be triggered by the activation of glutamate receptors. Here, we demonstrate that glutamate release at CA3-CA1 synapses is in fact inhibitory and unnecessary for increases in Pr. Instead, at active presynaptic terminals, postsynaptic depolarization alone can increase Prby promoting the release of nitric oxide from neuronal dendrites in a manner dependent on L-type voltage-gated Ca2+channels. The release of glutamate, in contrast, decreases Prby activating presynaptic NMDA receptors (NMDAR). Thus, net changes in Prare determined by the combined effect of both LTP-promoting and LTD-promoting processes, that is, by the amount of glutamate release and postsynaptic depolarization that accompany presynaptic activity, respectively. Neither of these processes directly depends on the activation of postsynaptic NMDARs. We further show that presynaptic changes can be captured by a simple learning rule, in which the role of presynaptic plasticity is to ensure that the ability for a presynaptic terminal to release glutamate is matched with its ability to predict postsynaptic spiking.
Action learning approach to teaching business engineering methodology
Authors: Leyer Michael , Moormann Jürgen 
Published: January 2017

Purpose
The business engineering (BE) methodology is used to design process-oriented and customer-centred companies in a systematic and holistic way. However, BE demands a high learning effort with regard to the logical flow, instruments and supporting software. The purpose of this paper is to explore which elements of action learning are most useful regarding BE.

Design/methodology/approach
To enable students to learn BE, a graduate-level course based on action learning is designed. Within a one-week schedule, participants are guided through the three phases of BE covering 31 learning elements. A post-test measures the learning experience. Regression analysis identifies elements that lead to high learning performance.

Findings
Results from five courses with 79 students reveal that action learning is useful to obtain declarative and procedural knowledge of BE. Learning elements delivering theoretical input and the use of an exemplary case could be reduced, while more time should be devoted to group work on a self-developed case study.

Research limitations/implications
The paper is based on a specific course design for the topic of BE, which might limit the results’ transferability to other business process management (BPM) teaching areas. However, it provides implications about the decisive elements for learning how to design process-oriented companies.

Practical implications
The results can be used by instructors to design more meaningful courses on BE.

Originality/value
The paper delivers new insights into how issues of BPM should be taught. This area, particularly regarding BE, has received little research attention.
Modelling information flow and sharing matrix for fresh food supply chains
Authors: Nakandala Dilupa , Samaranayake Premaratne , Lau Henry , Ramanathan Krishnamurthy 
Published: January 2017

PurposeDespite much research on supply chain (SC) integration and the growing emphasis on recent information technology advancements as an enabler of improved performance, there has been limited research focussed specifically on information integration in supply chains (SCs). The purpose of this paper is to systematically review the literature on information integration in the fresh food supply chain (FFSC) from a holistic perspective.Design/methodology/approachLiterature review is done by systematically collecting and analysing the recent literature to identify various participant entities of the FFSC information network and their specific information needs.FindingsThe information needs of FFSC entities are diverse but the needs are common across multiple entities.Research limitations/implicationsThis study only reviewed the FFSC-related literature; an extended study of the food industry may reveal a more comprehensive view.Practical implicationsThese findings are useful for practitioners in understanding the participant entities in the information network and their information needs and for policymakers in formulating FFSC development initiatives.Originality/valueThe authors are not aware of another study that investigates the FFSC in a holistic approach, one that identifies the actors, their interactions and information needs.
The BPM lifecycle
Authors: Bernardo Ronaldo , Galina Simone Vasconcelos Ribeiro , Pádua Silvia Inês Dallavalle de 
Published: January 2017

Purpose
The purpose of this paper is to develop a conceptual framework that incorporates factors external to the organization into the business process management (BPM) lifecycle through dynamic capabilities (DCs), beginning with strategy and persisting through the business process transformation.

Design/methodology/approach
The study comprised four distinct phases. First, a literature review was conducted to identify validated theoretical models related to the topic. Then, a systematic review of the literature was conducted by accessing the EBSCOhost, ISI/Web of Science and Scopus databases, for the purpose of understanding how the relationship between BPM and DCs has been addressed. The third step was the identification of the meta-capabilities involved in the relationship between DC and BPM, the fourth step was the construction of a framework that integrated an external view into BPM through DC, and the final step evaluated these framework through a case study.

Findings
Ten texts were selected after a systematic literature review. The following main points of convergence were identified: DC contributes to the conceptualization and understanding of BPM, DC assists in the process of organizational change by promoting the adaptation of the company to the environment, and DC enhances BPM performance. A framework was developed and presented.

Practical implications
The proposed framework, which incorporates an external perspective into the BPM lifecycle through DCs, can be used by managers and researchers interested in the promotion of BPM.

Originality/value
The study shows how the sensing, seizing and transforming meta-capabilities can act to evaluate the outside-in perspective, serve as a benchmark for the alignment of business processes and enable the operationalization of emerging demands through the dynamic adaptation of processes.
Post-disaster resettlement and livelihood vulnerability in rural China
Authors: Chen Yong , Tan Yan , Luo Yong 
Published: January 2017

Purpose
Livelihood recovery is a top priority to sustain resettled communities. The purpose of this paper is to assess livelihood vulnerability of those displaced and resettled in the aftermath of the 2008 Wenchuan earthquake, China, based on a newly constructed locational adjustable framework.

Design/methodology/approach
The study takes two resettlement villages in Sichuan Province as case study areas. Face-to-face surveys using a structured questionnaire and semi-structured in-depth interviews were conducted to collect primary data in 2012-2013.

Findings
The findings show that distant resettlement of people post the Wenchuan earthquake has resulted in an increased livelihood vulnerability within resettlers and that they face more hazards post-resettlement when compared to host residents in the resettlement areas.

Research limitations/implications
The indicators considered for the livelihood vulnerability index (LVI) are only a subset that represents typical factors applicable in the context of rural settings of China. The LVI may vary if more indicators are incorporated or coefficients obtained using different methods.

Social implications
Highlights should be placed on livelihood assets and hazards to livelihood of the displaced people. During the transition period there is a pressing need for greater efforts to enhance migrants’ employment skills and assist them to restore viable livelihood activities.

Originality/value
This paper constructs a locational adjustable framework for analyzing and assessing livelihood vulnerability of disaster-induced resettlers from three aspects: livelihood hazards, livelihood assets and coping strategies.
Media attention and corporate disaster relief: evidence from China
Authors: Ouyang Zhe , Wei Jiuchang , Xiao Yu , Wang Fei 
Published: January 2017

PurposeThe purpose of this paper is to examine the impact of media attention on corporate disaster relief.Design/methodology/approachThe authors used a matched sample research design, which is considered more appropriate than a random sample design for studying events that have low-occurrence rates in general. For each donor firm in the Yushu earthquake, the authors matched the firm with a non-donor firm in the same industry and with a firm size of within ±30 percent of the total assets in the year prior to the year of the occurrence of the Yushu earthquake. Then, using the Baidu engine, which is the most popular Chinese search engine, the authors captured the online media attention to the donor firms and their disaster relief.FindingsThe authors found that media attention drove corporate disaster relief.Research limitations/implicationsAlthough the authors highlighted the role of the media as an important stakeholder in influencing corporate disaster relief, the authors did not fully explore the media’s influence. Future research should delve more deeply into the impact of the tenor of media coverage on corporate disaster relief.Originality/valueThis study reveals that the media, a particularly powerful stakeholder, can be a corporate disaster relief driver in China.
The role of justice for cooperation and contract’s moderating effect in construction dispute negotiation
Authors: Lu Wenxue , Li Zhi , Wang Siqi 
Published: January 2017

PurposeJustice, although well developed in the organisational field, has not been given adequate attention in the area of construction project dispute negotiations. Based on previous studies, the purpose of this paper is to more elaborately discuss whether each dimension of justice (distributive, procedural and interactional) is important for negotiators to cooperate in construction project dispute negotiation and whether their impact was moderated by the completeness of construction contract.Design/methodology/approachA survey of 164 prime negotiators from different construction projects was conducted. A stepwise multiple regression was employed to test the impact of each dimension of justice, and then a moderated multiple regression model was used to test the moderating effect of contract completeness.FindingsThe results indicated that, while distributive justice is related to cooperative behaviours, the impact of procedural justice and interactional justice also have great impact, and even more significantly related to cooperative behaviours. Moreover, while contractual obligatoriness positively moderates the relationship between procedural justice and cooperative behaviours, the term specificity negatively moderates the relationship between procedural and interactional justice and cooperative behaviours.Research limitations/implicationsFirst, the authors aimed to test the effect of justice on cooperative behaviours in construction dispute negotiations originally, but did not determine whether their relationship is mediated by any other factors. Second, contractual governance was chosen as the moderator; other factors may also influence behaviours in project dispute negotiations.Practical implicationsFirst, project dispute negotiators should not focus their attention solely on the distribution of the negotiation issues. For a cooperative approach, negotiators should also give strong consideration to whether their offers reflect procedural justice and whether their opponents are being treated fairly. Second, while contractual design may affect the frame surrounding the negotiations to help negotiators achieve an integrated outcome, they should give more attention to certain forms of justice.Originality/valueIn contrast to previous studies, the authors defined all three forms of justice in project dispute negotiations, and by adding all three forms of justice into the model, the authors attempted to investigate whether distributive, procedural and interactional justice were all related to cooperative behaviours in project dispute negotiations and to ascertain the extent to which each form of justice is important. Furthermore, the authors explored variations in the importance of each form of justice in negotiations under different contractual conditions.
Effects of a major disaster on skills shortages in the construction industry
Authors: Chang-Richards Yan , Wilkinson Suzanne , Seville Erica , Brunsdon David 
Published: January 2017

Purpose
The purpose of this paper is to empirically investigate the effects of a major disaster on the management of human resources in the construction sector. It sets out to identify the construction skills challenges and the factors that affected skills availability following the 2010/2011 earthquakes in Christchurch. It is hoped that this study will provide insights for on-going reconstruction and future disaster response with respect to the problem of skills shortages.

Design/methodology/approach
A triangulation method was adopted. The quantitative method, namely, a questionnaire survey, was employed to provide a baseline description. Field observations and interviews were used as a follow-up to ascertain issues and potential shortages over time. Three focus groups in the form of research workshops were convened to gain further insight into the feedback and to investigate the validity and applicability of the research findings.

Findings
The earthquakes in Christchurch had compounded the pre-existing skills shortages in the country due to heightened demand from reconstruction. Skills shortages primarily existed in seismic assessment and design for land and structures, certain trades, project management and site supervision. The limited technical capability available nationally, shortage of temporary accommodation to house additional workers, time needed for trainees to become skilled workers, lack of information about reconstruction workloads and lack of operational capacity within construction organisations, were critical constraints to the resourcing of disaster recovery projects.

Research limitations/implications
The research findings contribute to the debate on skills issues in construction. The study provides evidence that contributes to an improved understanding of the industry’s skills vulnerability and emerging issues that would likely exist after a major disaster in a resource-limited country such as New Zealand.

Practical implications
From this research, decision makers and construction organisations can gain a clear direction for improving the construction capacity and capability for on-going reconstruction. Factors that affected the post-earthquake skills availability can be considered by decision makers and construction organisations in their workforce planning for future disaster events. The recommendations will assist them in addressing skills shortages for on-going reconstruction.

Originality/value
Although the study is country-specific, the findings show the nature and scale of skills challenges the construction industry is likely to face following a major disaster, and the potential issues that may compound skills shortages. It provides lessons for other disaster-prone countries where the resource pool is small and a large number of additional workers are needed to undertake reconstruction.