bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-CD20 Antibody Prevents Red Blood Cell Alloimmunization in a Mouse Model
Authors: Elayeb Rahma , Tamagne Marie , Pinheiro Marion , Ripa Julie , Djoudi Rachid , Bierling Philippe , Pirenne France , Vingert Benoît 
Published: October 2017

AbstractAlloimmunization against RBCs can cause life-threatening delayed hemolytic transfusion reactions. Anti-CD20 Ab has recently been used to prevent alloimmunization. However, its effects remain unclear, particularly in lymphoid organs. We investigated the impact of murine anti-CD20 Ab in the blood and spleen. We assessed protocols for preventing primary alloimmunization and for abolishing established alloimmunization. Prophylactic protocols prevented alloimmunization. However, anti-CD20 treatment could only limit the further amplification of established alloimmunization. Residual B cell subtype distribution was disrupted in the spleen, but adoptive transfer studies indicated that these cells were neither plasma nor memory cells. Anti-CD20 Ab had a major effect on alloreactive CD4+ T cells, increasing the expansion of this population and its CD40 expression, while lowering its CD134 expression, thereby confirming its role in alloimmunization. In conclusion, this study shows that anti-CD20 immunotherapy can prevent RBC Ab development. However, this immunotherapy is limited by the increase in alloreactive CD4+ T lymphocytes. Nevertheless, treatment with anti-CD20 Abs should be considered for patients requiring transfusion with a very high risk of alloimmunization and life-threatening complications.
An Explicit Manin-Dem’janenko Theorem in Elliptic Curves
Authors: Viada Evelina 
Published: October 2017

AbstractLet be a curve of genus at least 2 embedded in E1 × … × EN, where the Ei are elliptic curves for i = 1, . . . , N. In this article we give an explicit sharp bound for the Néron–Tate height of the points of contained in the union of all algebraic subgroups of dimension < max(), where is the minimal dimension of a translate (resp. of a torsion variety) containing .As a corollary, we give an explicit bound for the height of the rational points of special curves, proving new cases of the explicit Mordell Conjecture and in particular making explicit (and slightly more general in the CM case) the Manin–Dem’janenko method for curves in products of elliptic curves.
Uniform Convergence of Trigonometric Series with General Monotone Coefficients
Authors: Dyachenko Mikhail , Mukanov Askhat , Tikhonov Sergey 
Published: October 2017

AbstractWe study criteria for the uniform convergence of trigonometric series with general monotone coefficients. We also obtain necessary and sufficient conditions for a given rate of convergence of partial Fourier sums of such series.
Intervention to Improve Medication Management: Qualitative Outcomes From a Phase I Randomized Controlled Trial
Authors: Schwartz Jaclyn K. , Grogan Kimberly A. , Mutch Melissa J. , Nowicki Emily B. , Seidel Elizabeth A. , Woelfel Stefanie A. , Smith Roger O. 
Published: October 2017

AbstractOBJECTIVES. We sought to define an occupational therapy intervention to promote medication management and to evaluate the acceptability and effectiveness of the intervention.METHOD. Nineteen adults with chronic health conditions and poor medication adherence participated in a two-group, blinded, randomized study. They received either an occupational therapy or a standard care intervention. We used a qualitative method to measure participants’ changes in medication management through an interview regarding participants’ perceptions and behaviors.RESULTS. The occupational therapy intervention group reported greater improvements in medication management and implemented twice as many new adaptive strategies as the standard care group. Participants indicated that interventions related to advocacy, education, assistive technology, environmental modifications, self-monitoring, and good rapport were the active ingredients of the intervention.CONCLUSIONS. Occupational therapy is an acceptable intervention for medication management, and it can lead to self-perceived improvements and the adoption of new medication management behaviors. Further research is warranted.
A Study in the Humor of the Old Northeast: Joseph C. Neal's Charcoal Sketches and the Comic Urban Frontier
Authors: Sloane David E. E. 
Published: October 2017

ABSTRACT
Joseph C. Neal pioneered the urban frontier of the Old Northeast in depicting what he called “hard cases” from the Philadelphia slums in his long-overlooked Charcoal Sketches, first published in book form in 1838. His characters' inability to change with the times, their false and vulnerable toughness, and their urban vernacular language look forward to the humor of Mark Twain, political commentators, and radio and TV sitcoms. In Neal's work, the cash economy, the lightly ironic euphuistic character study, and metaphors of the city are used to describe the new social and ethical paradoxes of the urban-industrial world already emerging in the urban Northeast in his time.
Range of Motion of the First Metatarsophalangeal Joint After Different Capsulorrhaphies: A Comparative Cadaver Study
Authors: Xu Can , Li Mingqing , Wang Chenggong , Liu Hua 
Published: October 2017

Background:
Capsulorrhaphy restricts the motion of the first metatarsophalangeal joint (MTPJ) in hallux valgus surgery. However, changes in motion of the first MTPJ immediately after surgery that resulted from different capsulorrhaphy methods have not been compared. The primary aim of this study was to compare the immediate effect of Y-shaped and inverted L capsulorrhaphy methods on the range of motion (ROM) of the first MTPJ.

Methods:
Y-shaped and inverted L capsulorrhaphies were performed on 16 human cadaveric feet. Passive dorsiflexion and plantarflexion of the first MTPJ were then compared preoperatively and postoperatively.

Results:
In this cadaveric study, the inverted L capsulorrhaphy method led to a ROM loss in the first MTPJ; the joint stiffness from the Y-shaped capsulorrhaphy is significantly less than that from the inverted L capsulorrhaphy.

Conclusions:
The inverted L capsulorrhaphy may lead to a ROM loss in the first MTPJ immediately after surgery. We recommend that surgeons close the capsule of the first MTPJ with a Y-shaped capsulorrhaphy, which is less likely to result in a ROM loss in the first MTPJ in the early postoperative period.
Coculture of Spheroids/2D Cell Layers Using a Miniaturized Patterned Platform as a Versatile Method to Produce Scaffold‐Free Tissue Engineering Building Blocks
Authors: Oliveira Nuno M. , Martins‐Cruz Cláudia , Oliveira Mariana B. , Reis Rui L. , Mano João F. 
Published: October 2017

AbstractA hanging drop system that allows the multiconfigurational coculture of 3D microtissues is suggested as a versatile platform to promote the formation of functional preconditioned spheroids/microtissues, namely stem‐cell‐derived tissue engineering microtissues, with potential to be applied as scaffold‐free building blocks. Here, superhydrophobic (SH) platforms patterned with wettable regions are adapted for the production and culture of human adipose‐derived stem‐cell spheroids under indirect coculture with 2D layers of different cell types and direct coculture setups. The versatile indirect and direct coculture setups allow the use of cell lines as soluble biomolecules “factories” to continuously modulate microtissues response aspects, including their viability, cell number, and protein expression. This novel application of patterned SH platforms may find application in the massive production of modulated spheroids for the biomedical and pharmaceutical fields, with specific added value in the biofabrication of 3D constructs for tissue regeneration, as disease models, or even for organoids preparation.
Exposing Metal Oxide with Intrinsic Catalytic Activity by Near‐Infrared Pulsed Laser: Laser‐Induced Selective Metallization on Polymer Materials
Authors: Zhang Jihai , Zhou Tao , Xie Yi , Wen Liang 
Published: October 2017

AbstractIn this work, a facile strategy is presented for the fabrication of precisely metallized patterns on polymer substrate based on the copper‐free laser sensitizer through laser direct structuring (LDS) technology. A series of characterization methods are carried out to investigate the surface chemistry and morphology of polymer/antimony‐doped tin oxide (ATO) composites after laser activation and selective metallization. X‐ray photoelectron spectroscopy results show that a small part of Sn4+ and Sb5+ in ATO is reduced to Sn2+ and Sb3+, and it does not detect any Sn0 (elemental tin) after laser activation. This study confirms that ATO is a good copper‐free laser sensitizer and an efficient catalyst for selective metallization. Furthermore, the obtained copper layer is anchoring into the substrate leading to a superior adhesion property (highest 5 B level after Scotch tape test) between the copper layer and polymer substrate. Meanwhile, the obtained copper circuit line exhibits high conductivity (1.26 × 107 Ω−1 m−1) and excellent stability over time. This study also provides a guideline to develop copper‐free laser sensitizer for LDS technology.
Plasmonic Polarization‐Rotating Emitters with Metallic Nanogroove Antennas
Authors: Sun Chengwei , Li Hongyun , Gong Qihuang , Chen Jianjun 
Published: October 2017

AbstractA subwavelength plasmonic polarization‐rotating emitter is numerically and experimentally demonstrated by designing a metallic nanogroove antenna on the metal surface. The numerical simulation shows that there is a strong resonance in the nanogroove antenna when a surface plasmon polariton mode impinges it, and the polarization of the free‐radiation field emitted by the nanogroove antenna is mainly perpendicular to the long side of the nanogroove antenna. As a result, the polarization of the free‐radiation field can be easily rotated by tilting the nanogroove antenna. Experimentally, the metallic nanogroove antennas are fabricated, and the polarization‐rotating emitters are demonstrated. By tilting the nanogroove antenna with an angle of θ (<60°), the polarization of the free‐radiation field can be rotated by θ, and the linear polarization is nearly preserved in a broad bandwidth of Δλ = 180 nm. Because of the polarization rotation of the plasmonic emitter, it is demonstrated that the signal–noise ratio of the far‐field collection can be greatly improved. This subwavelength (0.07λ2) and broadband (Δλ = 180 nm) plasmonic polarization‐rotating emitter based on the nanogroove antenna provides a new degree of freedom to tailor the light emission from the confined waveguide modes on chips, and it may find important applications in the interchip optical communications.
Microglial dysfunction as a key pathological change in adrenomyeloneuropathy
Authors: Gong Yi , Sasidharan Nikhil , Laheji Fiza , Frosch Matthew , Musolino Patricia , Tanzi Rudy , Kim Doo Yeon , Biffi Alessandra , El Khoury Joseph , Eichler Florian 
Published: October 2017

ObjectiveMutations in ABCD1 cause the neurodegenerative disease, adrenoleukodystrophy, which manifests as the spinal cord axonopathy adrenomyeloneuropathy (AMN) in nearly all males surviving into adulthood. Microglial dysfunction has long been implicated in pathogenesis of brain disease, but its role in the spinal cord is unclear.MethodsWe assessed spinal cord microglia in humans and mice with AMN and investigated the role of ABCD1 in microglial activity toward neuronal phagocytosis in cell culture. Because mutations in ABCD1 lead to incorporation of very‐long‐chain fatty acids into phospholipids, we separately examined the effects of lysophosphatidylcholine (LPC) upon microglia.ResultsWithin the spinal cord of humans and mice with AMN, upregulation of several phagocytosis‐related markers, such as MFGE8 and TREM2, precedes complement activation and synapse loss. Unexpectedly, this occurs in the absence of overt inflammation. LPC C26:0 added to ABCD1‐deficient microglia in culture further enhances MFGE8 expression, aggravates phagocytosis, and leads to neuronal injury. Furthermore, exposure to a MFGE8‐blocking antibody reduces phagocytic activity.InterpretationSpinal cord microglia lacking ABCD1 are primed for phagocytosis, affecting neurons within an altered metabolic milieu. Blocking phagocytosis or specific phagocytic receptors may alleviate synapse loss and axonal degeneration. Ann Neurol 2017;82:813–827
Valence‐Engineering of Quantum Dots Using Programmable DNA Scaffolds
Authors: Shen Jianlei , Tang Qian , Li Li , Li Jiang , Zuo Xiaolei , Qu Xiangmeng , Pei Hao , Wang Lihua , Fan Chunhai 
Published: October 2017

AbstractPrecise control over the valency of quantum dots (QDs) is critical and fundamental for quantitative imaging in living cells. However, prior approaches on valence control of QDs remain restricted to single types of valences. A DNA‐programmed general strategy is presented for valence engineering of QDs with high modularity and high yield. By employing a series of programmable DNA scaffolds, QDs were generated with tunable valences in a single step with near‐quantitative yield (>95 %). The use of these valence‐engineered QDs was further demonstrated to develop 12 types of topologically organized QDs‐QDs and QDs‐AuNPs and 4 types of fluorescent resonance energy transfer (FRET) nanostructures. Quantitative analysis of the FRET nanostructures and live‐cell imaging reveal the high potential of these nanoprobes in bioimaging and nanophotonic applications.
Predictor Feedback Stabilization of Stochastic Linear Delayed Systems with Both Additive and Multiplicative Noises
Authors: Javadi Ali , Jahed‐Motlagh Mohammad Reza , Jalali Ali‐Akbar 
Published: October 2017

AbstractIn this paper we investigate memory control of stochastic linear delayed systems with both additive and multiplicative noises. A new formula is first presented to obtain the prediction vector from the system dynamics and then it is used for feedback to reduce the input delay in the original delayed system. To ensure the stability of closed‐loop system, some matrix inequality conditions are given that in the case of feasibility provide the stabilizing gain of the predictor controller. The proposed method is applied to stochastic quarter‐car model of an active suspension system to show the effectiveness of the approach.
Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression
Authors: Serra M. Pina , Poddighe Laura , Boi Marianna , Sanna Francesco , Piludu M. Antonietta , Corda M. Giuseppa , Giorgi Osvaldo , Quartu Marina 
Published: October 2017

AbstractIntroductionThe selective breeding of Roman High‐ (RHA) and Low‐Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies to aversive conditions. Thus, RLA rats are considered as a genetic model of vulnerability to stress‐induced depression whereas RHA rats are a model of resilience to that trait. Besides the monoamine hypothesis of depression, there is evidence that alterations in neuronal plasticity in the hippocampus and other brain areas are critically involved in the pathophysiology of mood disorders.Materials and MethodsWestern blot (WB) and immunohistochemistry were used to investigate the basal immunochemical occurrence of brain‐derived neurotrophic factor (BDNF) and its high‐affinity tyrosine‐kinase receptor trkB in the dorsal and ventral hippocampus of adult RHA and RLA rats.ResultsWB analysis indicated that the optical density of BDNF‐ and trkB‐positive bands in the dorsal hippocampus is, respectively, 48% and 25% lower in RLA versus RHA rats. Densitometric analysis of BDNF‐ and trkB‐like immunoreactivity (LI) in brain sections showed that BDNF‐LI is 24% to 34% lower in the different sectors of the Ammon's horn of RLA versus RHA rats, whereas line‐related differences are observed in the dentate gyrus (DG) only in the ventral hippocampus. As for trkB‐LI, significant differences are observed only in the dorsal hippocampus, where density is 23% lower in the DG of RLA versus RHA rats, while no differences across lines occur in the Ammon's horn.ConclusionThese findings support the hypothesis that a reduced BDNF/trkB signaling in the hippocampus of RLA versus RHA rats may contribute to their more pronounced vulnerability to stress‐induced depression.
Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10‐day decitabine regimen
Authors: Ali Alaa M. , Weisel Daniel , Gao Feng , Uy Geoffrey L. , Cashen Amanda F. , Jacoby Meagan A. , Wartman Lukas D. , Ghobadi Armin , Pusic Iskra , Romee Rizwan , Fehniger Todd A. , Stockerl‐Goldstein Keith E. , Vij Ravi , Oh Stephen T. , Abboud Camille N. , Schroeder Mark A. , Westervelt Peter , DiPersio John F. , Welch John S. 
Published: October 2017

AbstractDecitabine has been explored as a reduced‐intensity therapy for older or unfit patients with acute myeloid leukemia (AML). To better understand the risk of infections during decitabine treatment, we retrospectively examined the culture results from each infection‐related serious adverse event that occurred among 85 AML and myelodysplastic syndromes (MDS) patients treated in a prospective clinical study using 10‐day cycles of decitabine at Washington University School of Medicine. Culture results were available for 163 infection‐related complications that occurred in 70 patients: 90 (55.2%) events were culture‐negative, 32 (19.6%) were gram‐positive bacteria, 20 (12.3%) were gram‐negative bacteria, 12 (7.4%) were mixed, 6 (3.7%) were viral, 2 (1.2%) were fungal, and 1 (0.6%) was mycobacterial. Infection‐related mortality occurred in 3/24 (13%) of gram‐negative events, and 0/51 gram‐positive events. On average, nearly one third of patients experienced an infection‐related complication with each cycle, and the incidence did not decrease during later cycles. In summary, in patients receiving 10‐day decitabine, infectious complications are common and may occur during any cycle of therapy. Although febrile events are commonly culture‐negative, gram‐positive infections are the most frequent source of culture‐positive infections, but gram‐negative infections represent a significant risk of mortality in AML and MDS patients treated with decitabine.
Das Kupfer‐Problem 2.0
Authors: Zenner Christian , Scheuermann Hilda , Ropohl Mathias 
Published: October 2017

AbstractIm naturwissenschaftlichen Unterricht sind Schülervorstellungen zu zentralen Konzepten ein wichtiger Ausgangspunkt für die Gestaltung von Lernprozessen. Schülervorstellungen können als Hypothesen formuliert und in Experimenten überprüft werden. Im Rahmen einer Interventionsstudie wurden Hypothesen sowie Experimentplanungen hinsichtlich des von Hadfield [1] beschriebenen Kupfer‐Problems erhoben und analysiert. Im vorliegenden Beitrag wird dargestellt, welche Hypothesen bezüglich des schwarzen Belags auf einem erhitzten Kupferblech von Schülerinnen und Schülern aufgestellt werden, welche dieser Hypothesen in Experimentplanungen von ihnen überprüft werden und von welcher Qualität die Experimentplanungen sind. Die Ergebnisse deuten darauf hin, dass Schülerinnen und Schüler bestimmte Hypothesen bevorzugt überprüfen und dass die Qualität der Experimentplanungen von höherer Qualität ist, wenn Hypothesen auf einem niedrigen Verständnisniveau überprüft werden.
Low synovial double negative T and γδ T cells predict longer free‐disease survival in oligoarticular JIA
Authors: Licciardi Francesco , Ceci Maria , Toppino Claudia , Turco Marco , Martino Silvana , Ricotti Emanuela , Ferro Francesca , Montin Davide 
Published: October 2017

BackgroundOligoarticular juvenile idiopathic arthritis (oJIA) is the most frequent form of chronic arthritis in children; the clinical course is extremely variable. In this study we have characterized by flow cytometry synovial B and T cells subsets in patients with oJIA in order to identify any parameters that could predict a more aggressive course of disease.MethodsB and T cells from synovial fluid (SF) of 39 patients with oJIA were characterized by flow cytometry. In 22 patients SF was analysed at the onset of the disease (GroupA), in 17 SF was analysed at articular relapse (Group B). All patients in Group A were followed up for at least for 2 years after SF analysis: 13 patients relapsed during the follow‐up period.ResultsComparison of SF from Group A and Group B demonstrated an activated phenotype in relapsed patients, with higher Switched Memory B cells (58.53 vs 36.07% of CD19+, P‐value 0.004) and lower Naïve B cells (8.53 vs 25.9 of CD19+, P‐value 0.002) in Group B. Furthermore, patients from Group A who did not relapse showed lower percentages of synovial DNT (2.38 vs 1.50% of CD3 + TCRalpha/beta+, P‐value 0.025) and γδ T cells (19.1 vs 15.0% of CD3+ cells, P‐value 0.004) at the onset, if compared with other Group A patients.ConclusionsIn oJIA relapse SF present an activated B phenotype. Patients at disease onset with DNTs <1.8% and/or γδ T cells <16% of CD3+ in synovial fluid have longer free‐disease survival. © 2017 International Clinical Cytometry Society
α2‐glycine receptors modulate adult hippocampal neurogenesis and spatial memory
Authors: Lin Min‐Shan , Xiong Wen‐Chao , Li Shu‐Ji , Gong Zhi , Cao Xiong , Kuang Xiao‐Jing , Zhang Yuan , Gao Tian‐Ming , Mechawar Naguib , Liu Ce , Zhu Xin‐Hong 
Published: October 2017

ABSTRACTThe α2‐glycine receptors (GlyRs) play important roles during early central nervous system development. However, these receptors’ possible involvement in neurodevelopmental events occurring in the adult brain remains to be explored. Adult hippocampal neurogenesis (AHN) is the process by which new granule cell neurons are added to the dentate gyrus (DG) throughout adulthood. In this study, we observed that hippocampal adult neural stem cells (ANSCs) express α2‐containing GlyRs. Pharmacological inhibition of GlyRs by strychnine or picrotoxin decreased the proliferation of ANSCs, both in vivo and in vitro. Mice knockout for glra2, the gene coding for the GlyR α2 subunit, were determined to display impaired AHN, and this phenomenon was accompanied by deficits in spatial memory. These results, which reveal neurodevelopmental roles for α2‐GlyRs in the adult brain, may be clinically relevant, given that a mutation in GLAR2, as well as AHN impairments, have been reported in autism spectrum disorder. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1430–1441, 2017