bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ensemble model for engineered systems prognostics combining health index synthesis approach and particle filtering
Authors: Yongxiang Li , Jianming Shi , Gong Wang , Mengying Zhang 
Published: October 2017

AbstractPrognostics, in other words, remaining useful life (RUL) estimation is a core task of prognostics and health management (PHM). Reliable RUL predictions can reduce maintenance costs, improve production efficiency, and avoid unexpected downtime. Lots of models for RUL predictions have been proposed; however, noise and the nonlinear nature of degradation phenomena often leads to poor prognostics results, and the acquired engineered system data are usually subject to a high level of uncertainty. This makes the RUL estimation models less than satisfactory. Accurate RUL estimation and prediction not only rely on an accurate model but also depend on the adjustments of model parameters to track the variation. In this paper, an ensemble model combining the health index synthesis (HIS) approach and improved particle filtering (PF) is introduced. HIS approach was used to obtain the synthesized health index (SHI) for an engineered system with multiple sensors, which indicated the system's degradation model, while the improved PF approach was used to adjust the parameters of the degradation model obtained from the HIS approach and optimized the RUL estimation results. The performance of the prognostics approach introduced in this paper was demonstrated by using turbofan engine degradation data sets, which was supplied by NASA Ames, and results were compared with several usually used methods.
Epidemiology, diagnosis, and treatment of cerebrotendinous xanthomatosis (CTX)
Authors: Salen Gerald , Steiner Robert D. 
Published: October 2017

AbstractCerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of bile acid synthesis caused by mutations in the cytochrome P450 CYP27A1 gene that result in production of a defective sterol 27‐hydroxylase enzyme. CTX is associated with abnormally high levels of cholestanol in the blood and accumulation of cholestanol and cholesterol in the brain, tendon xanthomas, and bile. Hallmark clinical manifestations of CTX include chronic diarrhea, bilateral cataracts, tendon xanthomas, and neurologic dysfunction. Although CTX is a rare disorder, it is thought to be underdiagnosed, as presenting signs and symptoms may be nonspecific with significant overlap with other more common conditions. There is marked variability in signs and symptoms, severity, and age of onset between patients. The disease course is progressive and potentially debilitating or fatal, particularly with respect to neurologic presentations that can include intellectual disability, autism, behavioral and psychiatric problems, and dementia, among others. Treatment with chenodeoxycholic acid (CDCA; chenodiol) is the current standard of care. CDCA can help restore normal sterol, bile acid, bile alcohol, and cholestanol levels. CDCA also appears to be generally effective in preventing adverse clinical manifestations of the disease from occurring or progressing if administered early enough. Improved screening and awareness of the condition may help facilitate early diagnosis and treatment.
Entrepreneurial orientation and international performance: The moderating role of cultural intelligence
Authors: Şahin Faruk , Gürbüz Sai̇t 
Published: October 2017

AbstractAlthough the characteristics of top managers is an important factor associated with competitive advantage, and managerial resources are recognized as a firm’s major resource, there is limited research concerning the role of top manager’s capabilities in the relationship between entrepreneurial orientation and international performance. Based on the upper echelons perspective and resource-based view, the present study aimed to analyze top manager’s cultural intelligence as an internal contingency of the relationship between entrepreneurial orientation and international performance. The study’s theoretically derived research model was tested using survey data obtained from 206 small- and medium-sized enterprises. The findings suggested that the extent to entrepreneurial orientation was related to a firm’s international performance was contingent on the level of three dimensions of cultural intelligence (metacognitive, cognitive, and motivational). Furthermore, as the level of all four cultural intelligence dimensions of top managers increased, the relationship between entrepreneurial orientation and international performance increased in strength. The implications of the present findings for future research and practice were discussed.
Assessment of glacial-earthquake source parameters
Authors: VEITCH STEPHEN A. , NETTLES MEREDITH 
Published: October 2017

ABSTRACTGlacial earthquakes are slow earthquakes of magnitude M~5 associated with major calving events at near-grounded marine-terminating glaciers. These globally detectable earthquakes provide information on the grounding state of outlet glaciers and the timing of large calving events. Seismic source modeling of glacial earthquakes provides information on the size and orientation of forces associated with calving events. We compare force orientations estimated using a centroid-single-force technique with the calving-front orientations of the source glaciers at or near the time of earthquake occurrence. We consider earthquakes recorded at four glaciers in Greenland – Kangerdlugssuaq Glacier, Helheim Glacier, Kong Oscar Glacier, and Jakobshavn Isbræ – between 1999 and 2010. We find that the estimated earthquake force orientations accurately represent the orientation of the calving front at the time of the earthquake, and that seismogenic calving events are produced by a preferred section of the calving front, which may change with time. We also find that estimated earthquake locations vary in a manner consistent with changes in calving-front position, though with large scatter. We conclude that changes in glacial-earthquake source parameters reflect true changes in the geometry of the source glaciers, providing a means for identifying changes in glacier geometry and dynamics that complements traditional remote-sensing techniques.
Sea-ice thickness in the coastal northeastern Chukchi Sea from moored ice-profiling sonar
Authors: FUKAMACHI YASUSHI , SIMIZU DAISUKE , OHSHIMA KAY I. , EICKEN HAJO , MAHONEY ANDREW R. , IWAMOTO KATSUSHI , MORIYA ERIKA , NIHASHI SOHEY 
Published: October 2017

ABSTRACTTime series ice-draft data were obtained from moored ice-profiling sonar (IPS), in the coastal northeastern Chukchi Sea during 2009/10. Time series data show seasonal growth of sea-ice draft, occasionally interrupted by coastal polynya. The sea-ice draft distribution indicates a slightly lower abundance of thick, deformed ice compared with the eastern Beaufort Sea. In January, a rapid increase in the abundance of thick ice coincided with a period of minimal drift indicating compaction again the coast and dynamical thickening. The overall mean draft and corresponding derived thickness are 1.27 and 1.38 m, respectively. The evolution of modal ice thickness observed can be explained mostly by thermodynamic growth. The derived ice thicknesses are used to estimate heat losses based on ERA-interim data. Heat losses from the raw, 1 s IPS data are ~50 and 100% greater than those calculated using IPS data averaged over spatial scales of ~20 and 100 km, respectively. This finding demonstrates the importance of subgrid-scale ice-thickness distribution for heat-loss calculation. The heat-loss estimate based on thin ice data derived from AMSR-E data corresponds well with that from the 1 s observed ice-thickness data, validating heat-loss estimates from the AMSR-E thin ice-thickness algorithm.
Spatial and temporal variations of the surface albedo and other factors influencing Urumqi Glacier No. 1 in Tien Shan, China
Authors: YUE XIAOYING , ZHAO JUN , LI ZHONGQIN , ZHANG MINGJUN , FAN JIN , WANG LIN , WANG PUYU 
Published: October 2017

ABSTRACTGlacier albedo controls the surface energy budget, the variability of which affects the glacier surface melt rate and, in turn, impacts the mass balance of the glacier. During 2013 and 2014, spatial and temporal variations of albedo were investigated using 18 Landsat images of Urumqi Glacier No. 1. Factors influencing these spatiotemporal profiles were analyzed. An established retrieval process, including geolocation, radiometric calibration, atmospheric, topographic, and anisotropic correction and narrow- to broadband conversion, was applied for the first time to Landsat-8 images. Differences between Landsat image derived albedo values and albedo values measured using a handheld spectroradiometer ranged from −0.024 to 0.049. Spatial and temporal variations of surface albedo were significant, especially in the ablation area. The variability of the values of ice albedo ranged from 0.06 to 0.44 due to topographic effects and light-absorbing impurities. The results suggest that this retrieval method can be used to investigate the spatial and temporal variability of surface albedo from Landsat-8 images on mountain glaciers. Moreover, as constant albedo values for ice and snow cannot be assumed, the distribution of albedo was not completely dependent on altitude under conditions of more intense ablation, and by reason of light-absorbing impurities during the melt season.
239,240Pu and 236U records of an ice core from the eastern Tien Shan (Central Asia)
Authors: WANG CHAOMIN , HOU SHUGUI , PANG HONGXI , LIU YAPING , GÄGGELER HEINZ WALTER , CHRISTL MARCUS , SYNAL HANS-ARNO 
Published: October 2017

ABSTRACTRadioisotopes (239Pu, 240Pu, 236U) formed during atmospheric nuclear weapons testing (NWT) can be used for dating and therefore be applied as markers of the beginning of the Anthropocene Epoch. Moreover, 240Pu/239Pu ratios enable source identification (general fallout, local emission sources). Ice core segments from a 57.6 m ice core to bedrock from eastern Tien Shan, China were selected for 239,240Pu and 236U analyses by using compact low-energy accelerator mass spectrometry. The observed 240Pu/239Pu atom ratios were 0.18 ± 0.02, with one exception, indicating global fallout. No evidence for emissions from the nearby local sources Lop Nor was observed. The total deposition rates during NWT for 239Pu and 240Pu amount to 1.55 × 109 atoms·cm−2 and 3.1 × 108 atoms·cm−2, respectively. With the higher undisturbed fallout of 239Pu compared with values reported for glaciers from European Alps at Col du Dome and Colle Gnifetti as well as from the polar region, the eastern Tien Shan glacier would be an ideal site for defining the start of the Anthropocene. 236U is a rather new environmental tracer, while little is known about its global fallout from NWT. The observed deposition flux of 236U during NWT amounts to 3.5 × 108 atoms·cm−2 at the drill site. The average 236U/239Pu ratio of 0.27 ± 0.09 is in good agreement with literature values from global fallout.
Nematode assemblages associated with the parthenogenetic lizard Ameivula nativo in six restinga areas along the eastern coast of Brazil
Authors: Menezes V.A. , Mascarenhas J.C. , Vrcibradic D. , Rocha C.F.D. 
Published: October 2017

AbstractWe surveyed the nematode assemblages associated with populations of the parthenogenetic whiptail lizard Ameivula nativo from six coastal restinga areas in eastern Brazil: Setiba, Comboios and Guriri (State of Espirito Santo) and Guaratiba, Prado and Maraú (State of Bahia). A total of five nematode species (Physaloptera retusa, Physalopteroides venancioi, Skrjabinelazia intermedia, Subulura lacertilia and Parapharyngodon sp.) were recorded from the six different populations of A. nativo. There was considerable variation in overall prevalence of infection (1–42%) among study sites, but geographical distance among areas did not influence similarity in the composition of nematode assemblages. Overall intensity of infection was not affected by lizard body size and did not seem to affect host body condition, based on pooled data of all populations. The studied populations of the unisexual A. nativo had relatively low prevalences and intensities of infection compared to some bisexual congeners and to sympatric lizards from other families for which such data are available. We believe that the low richness of the nematode fauna associated with A. nativo, both locally and regionally, may reflect its narrow geographic distribution and the low diversity of habitats it occupies.
Description of a new species Fuhrmannetta jurubatensis n. sp. (Cestoda, Davaineidae) from Cerradomys goytaca Tavares, Pessôa & Gonçalves, 2011 (Rodentia, Cricetidae)
Authors: Oliveira L.C. , Oliveira F.C.R. , Ederli N.B. 
Published: October 2017

AbstractA new species of cestode of the genus Fuhrmannetta found in the small intestine of Cerradomys goytaca is described herein, named Fuhrmannetta jurubatensis n. sp. Rodents were collected from the sand-plains areas of the northern coast of the State of Rio de Janeiro, Brazil. Morphological analyses were conducted by light and scanning electron microscopy. From the morphological analysis and a comparison with the known species of the genus, F. jurubatensis n. sp. can be identified by a combination of morphological and morphometrical characteristics, including strobila length, number and length of rostellar hooks, position of the genital pore and the number of eggs per uterine capsule.
Is mesocardia with left-sided caval vein draining to coronary sinus a contraindication for a percutaneous pulmonary valve implantation? A case description
Authors: Kantzis Marinos , Happel Christoph M. , Haas Nikolaus A. 
Published: October 2017

AbstractIntroductionAlthough the right jugular vein approach for percutaneous pulmonary valve implantation is well described, there are no reports that describe a percutaneous pulmonary valve implantation through a left superior caval vein to coronary sinus pathway.CaseA 14-year-old female with tetralogy of Fallot, mesocardia, left superior caval vein draining into the coronary sinus, and hemiazygos continuation of the inferior caval vein underwent ventricular septal defect closure, with homograft insertion from the right ventricle to the pulmonary artery, patch augmentation of the left pulmonary artery, and creation of an atrial communication. Thereafter followed numerous catheterisations and interventions with stent implantation for stenosis of the left pulmonary artery and the homograft, as did device closure of the atrial communication. When she was a 12-year-old, the indications for a percutaneous pulmonary valve implantation were fulfilled and she underwent implantation of a 22 mm Melody® valve through the left superior caval vein. The extra-stiff exchange wire was pre-formed into a “U-spiral”-type configuration, according to the underlying anatomy, in order to provide a smooth route for the delivery of stents, to create the landing zone, and for the implantation of the Melody “ensemble”. The procedure was performed under deep sedation according to our standard protocol. The duration of the procedure was 172 min and the radiation time was 24.9 min.ConclusionOn the basis of this unique experience, percutaneous pulmonary valve implantation is safe and feasible even in patients with unusual anatomy. Crucial is the “U-spiral” shaped configuration of the guide wire.
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells
Authors: Malik Sakshi , Sadhu Srikanth , Elesela Srikanth , Pandey Ramendra Pati , Chawla Amanpreet Singh , Sharma Deepak , Panda Lipsa , Rathore Deepak , Ghosh Balram , Ahuja Vineet , Awasthi Amit 
Published: October 2017

AbstractInterleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. In addition to Th9, Th2, Th17 and Foxp3+regulatory T (Treg) cells produce IL-9. A transcription factor that is critical for IL-9 induction in Th2, Th9 and Th17 cells has not been identified. Here we show that the forkhead family transcription factor Foxo1 is required for IL-9 induction in Th9 and Th17 cells. We further show that inhibition of AKT enhances IL-9 induction in Th9 cells while it reciprocally regulates IL-9 and IL-17 in Th17 cells via Foxo1. Mechanistically, Foxo1 binds and transactivates IL-9 and IRF4 promoters in Th9, Th17 and iTreg cells. Furthermore, loss of Foxo1 attenuates IL-9 in mouse and human Th9 and Th17 cells, and ameliorates allergic inflammation in asthma. Our findings thus identify that Foxo1 is essential for IL-9 induction in Th9 and Th17 cells.
The chromosomal organization of horizontal gene transfer in bacteria
Authors: Oliveira Pedro H. , Touchon Marie , Cury Jean , Rocha Eduardo P. C. 
Published: October 2017

AbstractBacterial adaptation is accelerated by the acquisition of novel traits through horizontal gene transfer, but the integration of these genes affects genome organization. We found that transferred genes are concentrated in only ~1% of the chromosomal regions (hotspots) in 80 bacterial species. This concentration increases with genome size and with the rate of transfer. Hotspots diversify by rapid gene turnover; their chromosomal distribution depends on local contexts (neighboring core genes), and content in mobile genetic elements. Hotspots concentrate most changes in gene repertoires, reduce the trade-off between genome diversification and organization, and should be treasure troves of strain-specific adaptive genes. Most mobile genetic elements and antibiotic resistance genes are in hotspots, but many hotspots lack recognizable mobile genetic elements and exhibit frequent homologous recombination at flanking core genes. Overrepresentation of hotspots with fewer mobile genetic elements in naturally transformable bacteria suggests that homologous recombination and horizontal gene transfer are tightly linked in genome evolution.
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
Authors: Ren Xiaoming , Gelinas Amy D. , von Carlowitz Ira , Janjic Nebojsa , Pyle Anna Marie 
Published: October 2017

AbstractIL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its signaling pathway. By solving the crystal structure of the IL-1α/aptamer, we provide a high-resolution structure of this critical cytokine and we reveal its functional interaction interface with high-affinity ligands. The non-helical aptamer, which represents a highly compact nucleic acid structure, contains a wealth of new conformational features, including an unknown form of G-quadruplex. The IL-1α/aptamer interface is composed of unusual polar and hydrophobic elements, along with an elaborate hydrogen bonding network that is mediated by sodium ion. IL-1α uses the same interface to interact with both the aptamer and its cognate receptor IL-1RI, thereby suggesting a novel route to immunomodulatory therapeutics.
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice
Authors: He Wenqian , Chen Chi-Jene , Mullarkey Caitlin E. , Hamilton Jennifer R. , Wong Christine K. , Leon Paul E. , Uccellini Melissa B. , Chromikova Veronika , Henry Carole , Hoffman Kevin W. , Lim Jean K. , Wilson Patrick C. , Miller Matthew S. , Krammer Florian , Palese Peter , Tan Gene S. 
Published: October 2017

AbstractThe aim of candidate universal influenza vaccines is to provide broad protection against influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc–Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible for mediating this protection remain largely unknown. Here, we examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated protection. We demonstrate that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice. Our data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo, namely antibody-induced inflammation and antibody-dependent cellular phagocytosis. This study highlights the importance of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a better understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral response following influenza virus infection or immunization.
Mid-infrared dispersive wave generation in gas-filled photonic crystal fibre by transient ionization-driven changes in dispersion
Authors: Köttig F. , Novoa D. , Tani F. , Günendi M. C. , Cassataro M. , Travers J. C. , Russell P. St.J. 
Published: October 2017

AbstractGas-filled hollow-core photonic crystal fibre is being used to generate ever wider supercontinuum spectra, in particular via dispersive wave emission in the deep and vacuum ultraviolet, with a multitude of applications. Dispersive waves are the result of nonlinear transfer of energy from a self-compressed soliton, a process that relies crucially on phase-matching. It was recently predicted that, in the strong-field regime, the additional transient anomalous dispersion introduced by gas ionization would allow phase-matched dispersive wave generation in the mid-infrared—something that is forbidden in the absence of free electrons. Here we report the experimental observation of such mid-infrared dispersive waves, embedded in a 4.7-octave-wide supercontinuum that uniquely reaches simultaneously to the vacuum ultraviolet, with up to 1.7 W of total average power.
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Authors: Beltrán-Castillo S. , Olivares M. J. , Contreras R. A. , Zúñiga G. , Llona I. , von Bernhardi R. , Eugenín J. L. 
Published: October 2017

AbstractCentral chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis in the brain. CO2-induced ATP release from brainstem astrocytes stimulates breathing. NMDA receptor (NMDAR) antagonism reduces the CO2-induced hyperventilation by unknown mechanisms. Here we show that astrocytes in the mouse caudal medullary brainstem can synthesize, store, and release d-serine, an agonist for the glycine-binding site of the NMDAR, in response to elevated CO2 levels. We show that systemic and raphe nucleus d-serine administration to awake, unrestrained mice increases the respiratory frequency. Application of d-serine to brainstem slices also increases respiratory frequency, which was prevented by NMDAR blockade. Inhibition of d-serine synthesis, enzymatic degradation of d-serine, or the sodium fluoroacetate-induced impairment of astrocyte functions decrease the basal respiratory frequency and the CO2-induced respiratory response in vivo and in vitro. Our findings suggest that astrocytic release of d-serine may account for the glutamatergic contribution to central chemoreception.