bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energetic assessment of CO2 sequestration through slurry carbonation of steel slag: a factorial study
Authors: Costa Giulia , Polettini Alessandra , Pomi Raffaella , Stramazzo Alessio , Zingaretti Daniela 
Published: December 2016

AbstractAn assessment of the energetic requirements of slurry‐phase accelerated carbonation for CO2 sequestration using steelmaking slag was conducted. The results of dedicated lab‐scale carbonation experiments in which the CO2 sequestration yield of basic oxygen furnace slag was investigated at different operating conditions were used for the energy requirement calculations. The operating variables of the process and the associated values adopted were total gas pressure, temperature, and CO2 concentration in the gas phase. The energy duties of the slurry‐phase carbonation layout were calculated for the different unit operations, which included slag milling, mixing, slurry pumping, heating, CO2 compression, solid/liquid separation, and CO2 capture (when required). The estimated energy requirements were found to lie in the range 980−6300 MJ t−1 CO2 sequestered, where the lower end of the range was associated with the use of diluted CO2. In all cases, the use of a concentrated CO2 flow proved largely energetically unfavorable over the use of diluted gas streams, since the energy duty of the required CO2 capture stage by far overcame the benefits associated with improved sequestration yields at increased CO2 concentrations in the gas phase. The calculated energy requirements were also processed to derive a second‐order model accounting for the main effects and interactions between the operating variables of the carbonation process. The model developed is meant to predict the expected energy demand of the carbonation process under different operating conditions and to define the optimal combination of these in terms of the energetic profile of the process itself. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd.
The Mental Health of Children Providing Care to their Elderly Parent
Authors: Heger Dörte 
Published: December 2016

AbstractProviding care to a disabled parent can be a psychologically strenuous activity with potential negative consequences for the caregiver's mental health. At the same time, experiencing the declining health of a parent – often the very reason for the parent's care needs – can impact the adult child's mental health negatively. Because both events are usually observed simultaneously, disentangling the “caregiver effect” and the “family effect” remains a challenge. Using longitudinal data of the elderly population in Europe and an instrumental variable approach to address possible endogeneity concerns, this paper separately estimates the effect of caregiving and the decline of a parent's health on adult children's mental health. While I find negative but small caregiver and family effects for the “average” caregiver, the caregiver effect is multiplied for daughters if care provision is triggered by higher parental care needs. Copyright © 2016 John Wiley & Sons, Ltd.
Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells
Authors: Soundara Rajan Thangavelu , Giacoppo Sabrina , Scionti Domenico , Diomede Francesca , Grassi Gianpaolo , Pollastro Federica , Piattelli Adriano , Bramanti Placido , Mazzon Emanuela , Trubiani Oriana 
Published: December 2016

ABSTRACTIn the last years, mesenchymal stromal cells (MSCs) from oral tissues have received considerable interest in regenerative medicine since they can be obtained with minimal invasive procedure and exhibit immunomodulatory properties. This study was aimed to investigate whether in vitro pre‐treatment of MSCs obtained from human gingiva (hGMSCs) with Cannabidiol (CBD), a cannabinoid component produced by the plant Cannabis sativa, may promote human gingiva derived MSCs to differentiate toward neuronal precursor cells. Specifically, we have treated the hGMSCs with CBD (5 µM) for 24 h in order to evaluate the expression of genes involved in cannabidiol signaling, cell proliferation, self‐renewal and multipotency, and neural progenitor cells differentiation. Next generation sequencing (NGS) demonstrated that CBD activates genes associated with G protein coupled receptor signaling in hGMSCs. Genes involved in DNA replication, cell cycle, proliferation, and apoptosis were regulated. Moreover, genes associated with the biological process of neuronal progenitor cells (NCPs) proliferation, neuron differentiation, neurogenesis, and nervous system development were significantly modulated. From our results, we hypothesize that human gingiva‐derived MSCs conditioned with CBD could represent a valid method for improving the hGMSCs phenotype and thus might be a potential therapeutic tool in the treatment of neurodegenerative diseases. J. Cell. Biochem. 118: 1531–1546, 2017. © 2016 Wiley Periodicals, Inc.
MiR‐193b Mediates CEBPD‐Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells
Authors: Lin Siao‐Ren , Yeh Hsin‐Chih , Wang Wei‐Jan , Ke Hung‐Lung , Lin Hui‐Hui , Hsu Wei‐Chi , Chao Shih‐Yi , Hour Tzyh‐Chyuan , Wu Wen‐Jeng , Pu Yeong‐Shiau , Huang A‐Mei 
Published: December 2016

ABSTRACTTranscription factor CCAAT/enhancer‐binding protein delta (CEBPD) plays multiple roles in tumor progression. Studies have demonstrated that cisplatin (CDDP) induced CEBPD expression and had led to chemotherapeutic drug resistance. However, the underlying molecular mechanisms of CDDP‐regulated CEBPD expression and its relevant roles in CDDP responses remain elusive. MicroRNAs (miRNAs) are small non‐coding RNAs that negatively regulate gene expression in a sequence‐specific manner. Abnormal miRNAs expression is associated with tumor progression. In current study, a large‐scale PCR‐based miRNA screening was performed to identify CEBPD‐associated miRNAs in urothelial carcinoma cell line NTUB1. Eleven miRNAs were selected with more than twofold changes. MiR‐193b‐3p, a known tumor suppressor, down‐regulated proto‐oncogenes Cyclin D1, and ETS1 expression and led to cell cycle arrest, cell invasion, and migration inhibition. The expression of miR‐193b‐3p was associated with the DNA binding ability of CEBPD in CDDP response. CEBPD knocking‐down approach provided a strong evidence of the positive correlation between CEBPD and miR‐193b‐3p. CDDP‐induced CEBPD trans‐activated miR‐193b‐3p expression and it directly targeted the 3′‐UTR of Cyclin D1 and ETS1 mRNA, and silenced the protein expression. In addition, miR‐193b‐3p also inhibited cell migration activity, arrested cell at G1 phase, and sensitized NTUB1 to CDDP treatment. In conclusion, this study indicates that CEBPD exhibits an anti‐tumorigenic function through transcriptionally activating miR‐193b‐3p expression upon CDDP treatment. This study provides a new direction for managing human urothelial carcinoma. J. Cell. Biochem. 118: 1563–1573, 2017. © 2016 Wiley Periodicals, Inc.
Combined Therapy With Swimming Exercise and a Diet Supplemented With Diphenyl Diselenide Is Effective Against Age‐Related Changes in the Hepatic Metabolism of Rats
Authors: Heck Suélen O. , Fulco Bruna C.W. , Quines Caroline B. , Oliveira Carla E.S. , Leite Marlon R. , Cechella José L. , Nogueira Cristina W. 
Published: December 2016

ABSTRACTAging is characterized by a widespread loss of homeostasis in biological systems and is accompanied by pathophysiological changes including the liver injury. The aim of the present study was to investigate the effects of the combined therapy with swimming exercise (20 min session, 5 days/week during 4 weeks) and a diet supplemented with 1 ppm of (PhSe)2 on the hepatic metabolic alterations caused by aging in rats. In this study, male old Wistar rats had an increase in the epididymal fat relative weight, disturbances in the activities of hepatic enzymes associated to the glucose homeostasis, higher hepatic triglyceride content and higher activity of the plasma alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The combined therapy normalized the activities of glucose‐6‐Pase and tyrosine aminotransferase, gluconeogenic enzymes, increased the hepatic glycogen content and was effective against the increase in the hepatic triglycerides content, without altering the activities of hexoquinase, and citrate synthase. Moreover, the combined therapy normalized the activities of AST and ALT, indicating a hepatoprotective effect. The combined therapy with swimming exercise and a diet supplemented with 1 ppm of (PhSe)2 contributed to the hepatic glucose homeostasis in old rats. Nevertheless, more studies are needed to investigate the possible mechanisms of action behind these effects. J. Cell. Biochem. 118: 1574–1582, 2017. © 2016 Wiley Periodicals, Inc.
A biosynthesis view on nutrient stress in coastal phytoplankton
Authors: Grosse Julia , van Breugel Peter , Brussaard Corina P. D. , Boschker Henricus T. S. 
Published: December 2016

AbstractAnthropogenic activities resulted in major shifts in nutrient inputs to coastal seas, which may have altered the biomolecule composition of phytoplankton because of different C : N : P requirements for biosynthesis. In order to understand the effects of N‐ and P‐limitation on the allocation of photosynthetically fixed C, we directly measured seasonal and spatial dynamics of amino acid, fatty acid and carbohydrate concentrations and biosynthesis rates in the phytoplankton of the North Sea using a novel 13C‐tracer approach. Nutrient limitation and season had large effects on composition and biosynthesis rates of all biochemical classes, for instance the contribution of protein derived amino acids varied up to fourfold in concentration and up to eightfold in biosynthesis rates. Nutrient specific effects and the prevailing nutrient limitations were identified by short‐term (24–72 h) nutrient addition experiments. Addition of the growth‐limiting nutrient increased amino acid synthesis while storage compound synthesis decreased concurrently. The strongest effect was detected in N‐limited flagellates, where amino acid synthesis increased up to fivefold within 24 h upon relief of nutrient limitation. P‐limitation was only detected in diatom‐dominated near‐coast stations, and amino acid synthesis responded much slower, likely because of the necessary preceding synthesis of ribosomes. This metabolic elasticity of phytoplankton in response to nutrient availability will have major consequences for their nutritional value within the food web and subsequently the carrying capacity of coastal ecosystems.
Multi‐Functional Polyurethane Hydrogel Foams with Tunable Mechanical Properties for Wound Dressing Applications
Authors: Lundin Jeffrey G. , Daniels Grant C. , McGann Christopher L. , Stanbro Joshua , Watters Chaselynn , Stockelman Michael , Wynne James H. 
Published: December 2016

Polyurethane hydrogel foams synthesized through a facile one‐pot, solvent‐free process are described. The roles of polyethylene glycol (PEG) molecular weight, crosslinking density, and foam stabilizer concentration on polymer properties are evaluated for potential applications as wound dressing materials. Material characterization and wound dressing relevant performance evaluations are performed to understand effects of individual components and identify promising formulations. Surprisingly for a solvent‐free reaction, complete polymerization is confirmed by IR and gel fraction analyses. Foam stabilizing agent loading increases mechanical properties including Young's modulus, extensibility, and toughness while decreasing pore size and drug release rate. Mechanical properties are also dependent on the crystalline melting temperature of the PEG diol. Utilizing caffeine as a drug surrogate, high performance liquid chromatography (HPLC) drug‐release analysis identifies that polyurethane hydrogel foams exhibit initial burst release kinetics followed by sustained release over 24 h. Antibiotic compatibility and release is demonstrated for all formulations by zone of inhibition testing against gram‐positive and negative bacteria.
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The ultimate signal‐to‐noise ratio in realistic body models
Authors: Guérin Bastien , Villena Jorge F. , Polimeridis Athanasios G. , Adalsteinsson Elfar , Daniel Luca , White Jacob K. , Wald Lawrence L. 
Published: December 2016

PurposeWe compute the ultimate signal‐to‐noise ratio (uSNR) and G‐factor (uGF) in a realistic head model from 0.5 to 21 Tesla.MethodsWe excite the head model and a uniform sphere with a large number of electric and magnetic dipoles placed at 3 cm from the object. The resulting electromagnetic fields are computed using an ultrafast volume integral solver, which are used as basis functions for the uSNR and uGF computations.ResultsOur generalized uSNR calculation shows good convergence in the sphere and the head and is in close agreement with the dyadic Green's function approach in the uniform sphere. In both models, the uSNR versus B0 trend was linear at shallow depths and supralinear at deeper locations. At equivalent positions, the rate of increase of the uSNR with B0 was greater in the sphere than in the head model. The uGFs were lower in the realistic head than in the sphere for acceleration in the anterior‐posterior direction, but similar for the left‐right direction.ConclusionThe uSNR and uGFs are computable in nonuniform body models and provide fundamental performance limits for human imaging with close‐fitting MRI array coils. Magn Reson Med 78:1969–1980, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Im Glashaus leben, wachsen, sich vermehren
Authors: Pohnert Georg 
Published: December 2016

AbstractKieselalgen haben Zellwände aus biomineralisiertem Silikat. Um diese aufzubauen, nehmen sie gelöste Kieselsäure auf und scheiden diese ab. Die Mikroalgen sind aber nicht nur Baumeister, sie erspüren die Kieselsäure auch und orientieren sich an Gradienten dieser anorganischen Ressource.
International Continence Society Good Urodynamic Practices and Terms 2016: Urodynamics, uroflowmetry, cystometry, and pressure‐flow study
Authors: Rosier Peter F.W.M , Schaefer Werner , Lose Gunnar , Goldman Howard B. , Guralnick Michael , Eustice Sharon , Dickinson Tamara , Hashim Hashim 
Published: December 2016

AimsThe working group initiated by the ICS Standardisation Steering Committee has updated the International Continence Society Standard “Good Urodynamic Practice” published in 2002.MethodsOn the basis of the manuscript: “ICS standard to develop evidence‐based standards,” a new ICS Standard was developed in the period from December 2013 to December 2015. In July, a draft was posted on the ICS website for membership comments and discussed at the ICS 2015 annual meeting. The input of ICS membership was included in the final draft before ICS approval and subsequent peer review (for this journal).ResultsThis evidence‐based ICS‐GUP2016 has newly or more precisely defined more than 30 terms and provides standards for the practice, quality control, interpretation, and reporting of urodynamics; cystometry and pressure‐flow analysis. Furthermore, the working group has included recommendations for pre‐testing information and for patient information and preparation. On the basis of earlier ICS standardisations and updating according to available evidence, the practice of uroflowmetry, cystometry, and pressure‐flow studies are further detailed.ConclusionICS‐GUP2016 updates and adds on to ICS‐GUP2002 to improve urodynamic testing and reporting both for individual care and scientific purposes.
Tuning the Phase and Shape of Copper Sulfide Nanostructures Using Mixed Solvent Systems
Authors: Khan Malik D. , Akhtar Javeed , Malik Mohammad A. , Revaprasadu Neerish 
Published: December 2016

AbstractPhase pure copper sulfide nanoparticles with various shapes and superlattices were synthesized using Bis(O‐isobutyldithiocarbonato)copper(II) complex as single source precursor (SSP) by the hot injection method. Optimization of reaction conditions provide mono‐disperse nanospheres, nanorods, hexagonal disks and cubic nanoparticles. Furthermore, self‐assembly of highly monodispersed nanoarrays were also obtained by tuning reaction parameters. The kinetics of decomposition of the SSP under the influence of activating and/or stabilizing agents is discussed.
A new platychelyid turtle (Pan‐Pleurodira) from the Late Jurassic (Kimmeridgian) of Oaxaca, Mexico
Authors: López‐Conde Oliver A. , Sterli Juliana , Alvarado‐Ortega Jesus , Chavarría‐Arellano María L. 
Published: December 2016

AbstractUntil recently, the record of Mesozoic turtles in Mexico has been restricted to the Cretaceous. New discoveries in the Sabinal Formation (Tlaxiaco, Oaxaca) have extended the record into the Kimmeridgian (Late Jurassic). The Sabinal Formation is part of the Tlaxiaco Basin, which was a depocenter of continental and marine sediments dominated by transgressive‐regressive marine conditions during the Jurassic–Cretaceous. The new turtle described here consists of an almost complete carapace associated with a plastron. Based on the unique combination of characters, this turtle is identified as a new species of Platychelyidae here namedNotoemys tlaxiacoensis. Platychelyid characters in this specimen include the presence of the sulcus between vertebral 3 and 4 located on neural 6, the presence of a central plastral fontanelle, and a pair of reduced mesoplastra. The occurrence of Kimmeridgian platychelyids in Mexico confirms that the Hispanic Corridor acted as a connection between Tethyan and Palaeopacific faunas.
Zum Ermüdungsverhalten von Grout‐Verbindungen bei unterschiedlichen Umgebungsbedingungen
Authors: Schaumann Peter , Raba Alexander , Bechtel Anne 
Published: December 2016

AbstractHerrn Univ. Prof. Dr.‐Ing. Gerhard Hanswille zur Vollendung seines 65. Lebensjahres gewidmetGrout‐Verbindungen sind ein häufig eingesetztes Konstruktionsdetail in Offshore‐Windenergieanlagen und ‐Plattformen. Sie stellen eine lastabtragende Verbindung zwischen gerammten Pfählen und Tragstruktur her. Bei aufgelösten Unterstrukturen befindet sich diese Verbindung üblicherweise unter Wasser. Ein möglicher Wassereinfluss auf das Ermüdungsverhalten des Konstruktionsdetails wurde in früheren Versuchen und den daraus abgeleiteten Bemessungsverfahren nicht berücksichtigt. Die in dieser Veröffentlichung beschriebenen versuchsgestützten Untersuchungen zeigen an klein‐ und großskaligen Versuchskörpern eine deutliche Reduktion der Lebensdauer bei Ermüdungsbeanspruchung unter Wasser gegenüber trockenen Umgebungsbedingungen. Neben einer Beeinflussung der Lebensdauer verändert das umgebende Wasser auftretende Schadensmechanismen in der Verbindung.On the fatigue behaviour of grouted connections at varied ambient conditions. Grouted connections are a frequently used structural detail of offshore wind turbines and platforms for the load transferring connection between piles and support structure. At latticed substructures this connection is commonly located at mudline. However, a potential influence of the surrounding water on the connection's fatigue behaviour was neglected in earlier tests and consequential design methods. Herein described experimental investigations at small and large‐scale fatigue tests in submerged conditions, showed a significant reduction of endurable load cycles. In addition, the water impact caused varied damage mechanism in the connection.
Verschlüsse und Antriebe am Sperrwerk Greifswald
Authors: Heyder Frank , Hohberg Andreas , Lettner Christian 
Published: December 2016

AbstractDas Sperrwerk Greifswald an der Mündung des Ryck in den Greifswalder Bodden bildet den Kern des Sturmflutschutzes für Greifswald. Durch einen Hauptverschluss als Drehsegment und zwei Nebenverschlüssen als Schiebetore können 60 m Fluss und Uferbereich zwischen den angrenzenden Deichen im Sturmflutfall verschlossen werden. Der Hauptverschluss wurde als Drehsegment konzipiert, um den Schifffahrtsweg so wenig wie möglich einzuschränken. In Ruheposition liegt das Drehsegment in einer Mulde in der Bodenplatte unterhalb des Flussgrundes. Bei Sturmflutwarnung wird das Drehsegment über zwei Hydraulikzylinder um 90° in die Staustellung gedreht. Die Nebenverschlüsse sichern die Promenadenbereiche links und rechts vom Ryck. Sie wurden als Schiebetore ausgebildet, die normalerweise in Kammern im benachbarten Deich stehen und bei Sturmflutwarnung über Elektromotoren ausgefahren werden. Haupt‐ und Nebenverschlüsse wurden als geschweißte räumliche Schalentragwerke ausgebildet und mit FEM‐Software als jeweils ein Bauteil bemessen. Die besondere Herausforderung dieses Bauvorhabens war das Zusammenwirken von Wasser‐ und Spezialtiefbau, Betonbau, Stahlbau, Maschinenbau und Elektrotechnik.Gates and drives of the Greifswald flood barrier – contemporary steel construction for hydraulic gates – Part 1: Design and structural analysis. The Greifswald flood barrier at the river Ryck at Baltic Sea is the essential part of flood barrier activities ensuring the safety of the city of Greifswald in case of wind‐induces flooding. The main gate is a segment gate in the river, spanning 21 m, accompanied by two 19 m spanning secondary gates formed by sliding doors covering the waterfronts. The segment gate in the rivers ensures minimum interruption of the navigation. In normal position, the segment rests in a recess of the foundation slab. In case of a flood warning, huge hydraulic rams turn the segment into the 90° close position. The sliding doors allow its storage in adjacent chambers, fully covered by the embankments, and roll into its close position driven by electric engines. Both main segment gate and secondary sliding gates are spatial welded steel constructions designed as one unit by finite element software. The most challenging part of the project turned out to be the coordination of knowledge and specialists in water construction, special heavy construction, concrete technology, mechanical and electrical engineering.
Die überarbeitete DASt‐Richtlinie 022 zum rissfreien Verzinken
Authors: Feldmann Markus , Schaffrath Simon , Schäfer Dirk 
Published: December 2016

AbstractHerrn Univ.‐Prof. Dr.‐Ing. Gerhard Hanswille zur Vollendung seines 65. Lebensjahres gewidmetUnter ungünstigen Bedingungen kann das Feuerverzinken von großen, tragenden Stahlbauteilen Rissbildung nach sich ziehen, was aufgrund der Standsicherheitsrelevanz zu einer Reihe von Forschungsarbeiten geführt hat. Die Ergebnisse sind in 2009 in die DASt‐Richtlinie 022 zum rissfreien Feuerverzinken eingeflossen. Nach sieben Jahren erfolgreicher Anwendung ist die DASt‐Richtlinie 022 nun überarbeitet worden. Der Beitrag erläutert die Änderungen und Ergänzungen, die sich neben Vereinfachungen im Regeltext und der Handhabung der Norm in erster Linie auf neue Ergebnisse zu Kaltverformungen, des Flussmittelgehalts und der Ausbildung von Fachwerkkonstruktionen auf die Rissanfälligkeit beim Feuerverzinken beziehen. Darüber hinaus sind nunmehr erstmalig Regeln für das Feuerverzinken im Hochtemperaturbereich (530 °C bis 620 °C) aufgenommen worden. Hinweise auf verbesserte Angaben zu Mindestgrößen von Durchlauföffnungen runden den Aufsatz ab.The revised guideline DASt‐Richtlinie 022 on preventing cracks during hot dip galvanizing. Hot dip galvanizing of structural steel elements may lead to cracking if the conditions are not favourable. Due to the safety relevance a series of research work has been carried out the results of which led to the DASt‐Richtlinie 022 on the prevention of cracking during hot dip galvanizing. After seven years of successful use the DASt‐Richtlinie 022 now has been revised. The paper explains the changes and amendments of this German code. Apart from simplification, the alternations refer to new results on the crack‐susceptibility of cold forming, the salt‐content of the flux and the layout of lattice girders. Moreover, for the first time now, rules on hot dip galvanizing in the high temperature range (530 °C to 620 °C) have been developed. Finally recommendations on ventilation hole‐diameters are given.