bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left atrial appendage occlusion: Fighting the “dark side” of atrial fibrillation
Authors: Meucci Francesco , Di Mario Carlo 
Published: February 2017

Key points

In this real world UK retrospective experience LAAO confirms its safety profile with one procedure related death (0.25%), and 3.5% incidence of major adverse events.
There is a significant learning curve effect (acute major events were reduced from 6.5 to 0.5% between first and second half of enrollment)
The two most widely used devices (Watchman and Amplatzer) did not differ in terms of safety and efficacy in immediate success (95%) and late reduction of expected ischemic events, confirming a class effect of LAAO therapy
In a rapidly changing environment, further research is needed to understand whether LAAO should remain confined to a niche group with absolute contraindications to OAT or can be extended to patients at high bleeding risk with both VKA and NOACs.
Synthesis of 1,5‐Pentanediol by Hydrogenolysis of Furfuryl Alcohol over Ni–Y2O3 Composite Catalyst
Authors: Wijaya Husni Wahyu , Kojima Takashi , Hara Takayoshi , Ichikuni Nobuyuki , Shimazu Shogo 
Published: February 2017

AbstractThe addition of Y2O3 into Ni formed a composite catalyst that selectively produced 1,5‐pentanediol rather than 1,2‐pentanediol in the hydrogenolysis of furfuryl alcohol at 2.0 MPa H2 and 423 K. Clearly, 1,5‐pentanediol was produced over the Ni0–Y2O3 boundary. This report highlights the properties of Ni–Y2O3, catalytic performance, and reaction route in the synthesis of 1,5‐pentanediol from furfuryl alcohol.
Rhodium(III) Catalyzed Solvent‐Free Tandem Isomerization–Hydrosilylation From Internal Alkenes to Linear Silanes
Authors: Azpeitia Susan , Garralda María A. , Huertos Miguel A. 
Published: February 2017

AbstractThe selective synthesis of linear silanes from internal alkenes or alkene mixtures is reported. Unsaturated 16 electrons hydrido–silyl–RhIII complexes are efficient catalysts for a tandem catalytic alkene isomerization–hydrosilylation reaction at room temperature under solvent‐free conditions. Such a process would be of value to the chemical industry, as mixtures of internal aliphatic olefins are substantially cheaper and more readily available than the pure terminal isomers.
N‐Heterocyclic Carbene Based Tri‐organyl‐Zn–Alkyl Cations: Synthesis, Structures, and Use in CO2 Functionalization
Authors: Specklin David , Fliedel Christophe , Gourlaouen Christophe , Bruyere Jean‐Charles , Avilés Teresa , Boudon Corinne , Ruhlmann Laurent , Dagorne Samuel 
Published: February 2017

AbstractTri‐organyl and tricoordinate N‐heterocyclic carbene (NHC) Zn–NHC alkyl cations [(nNHC)2Zn‐Me]+ (nNHC=C2‐bonded‐IMes/‐IDipp; 3+ and 4+; IMes=1,3‐bis(2,4,6‐trimethylphenyl)imidazolin‐2‐ylidene, IDipp=1,3‐bis(2,6‐diisopropylphenyl)imidazolin‐2‐ylidene) were first synthesized and structurally characterized by ionization of the corresponding neutral precursors [(nNHC)ZnMe2] with [Ph3C][B(C6F5)4] in the presence of one equivalent of free NHC. Whereas cation [(nIMes)2Zn‐Me]+ (3+) is stable, its sterically congested analogue [(nIDipp)2Zn‐Me]+ (4+) readily undergoes an nNHC‐to‐aNHC isomerization in the presence of THF or IDipp to afford the more thermodynamically stable [(aIDipp)(nIDipp)Zn‐Me]+ (aIDipp=C4‐bonded IDipp, 5+), reflecting the adaptable‐to‐sterics coordination chemistry of these cations for improved stability. Cations 3+–5+ are the first Zn cations of the type Zn(C)(C′)(C′′)+ (C, C′, C′′=σ‐donor carbyl ligand). Kinetic studies combined with DFT calculations agree with an nNHC‐to‐aNHC process proceeding through the initial deprotonation of 4+ (at a Zn‐bonded C4‐IDipp moiety) by IDipp. Unlike 3+ and 4+, the rearranged cation 5+ reacts with CO2 through insertion into the Zn–Me bond yielding the corresponding Zn(κ2‐OAc)+ cation 6+. Both cations 5+ and 6+ were successfully used in CO2 hydrosilylation catalysis for silylformate formation.
Monoprotected l‐Amino Acid (l‐MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp2)−H Bonds by Iridium(III) Catalysis
Authors: Kathiravan Subban , Nicholls Ian A. 
Published: February 2017

AbstractHalogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono‐protected l‐amino acid (l‐MPAA) accelerated iridium(III)‐catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/l‐MPAA‐catalyzed general halogenation of (hetero)arenes through C(sp2)−H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.
Do Perceived Operational Impacts Affect the Portfolio of Carbon‐Abatement Technologies?
Authors: Chen Chien‐Ming , Montes‐Sancho Maria J. 
Published: February 2017

AbstractFirms face a variety of stakeholder pressures to improve their environmental performance. A firm's perceptions of these pressures can radically affect its strategic reactions and subsequent resource allocation decisions. Previous studies do not explain how perceived operational impacts may influence a firm's investment in environmental technologies. This study examines the relationship between perceived impacts on process and product and carbon preventive projects within firms' environmental technology portfolio. Using carbon emissions and carbon disclosure data, we find that higher perceived process‐related impacts are associated with a higher proportion of carbon preventive projects, while perceived product‐related impacts have the opposite effect. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
An energy‐efficient algorithm based on sleep‐scheduling in IP backbone networks
Authors: Dabaghi-Zarandi Fahimeh , Movahedi Zeinab 
Published: February 2017

SummaryThis paper relates to the problem of energy conservation in Internet backbone networks. We propose a new Distributed Green Algorithm based on Sleep‐scheduling (DGAS) to switch off some network links and nodes resulting in less energy consumption. Our solution does not depend on any centralized controller and uses a link‐state protocol like Open Shortest Path First to share required information. In addition, DGAS does not require any knowledge of traffic matrix and switches off network nodes and links in 2 phases. In the first phase, some core nodes are switched off on the basis of their usage in network paths. In the second phase, DGAS starts with a minimal topology on the basis of resulted topology from the first phase and adds some links to it to minimize network paths length. Results, obtained by several real network scenarios, show that DGAS can switch off up to 27% of core nodes and up to 80% of links compared to the maximum number of switchable links.
New national construction product regulations of the German states
Authors: Halstenberg Michael 
Published: February 2017

AbstractThe European Court of Justice ruled in October 2014 that Germany had infringed the EU Construction Products Regulation because additional national requirements for harmonised products had been imposed in three cases. This means that the German practice until now, that additional national technical requirements are also imposed on harmonised construction products, will have to be abandoned. Germany has assured the EU Commission that the building regulation law will be appropriately changed by 16/10/2016. This could however not been implemented on time for various reasons, so the German states have issued enforcement decrees in order to adapt the legal situation to the ECJ judgment.The legal situation at the moment is fairly complex and confusing. This article provides a brief overview.
Is fine needle aspiration really not necessary in patients with thyroid nodules ≤ 1 cm with highly suspicious features on ultrasonography and candidates for active surveillance?
Authors: Rosario Pedro Weslley , Silva Alexandre Lemos , Calsolari Maria Regina 
Published: February 2017

BackgroundThe low rate of progression associated with the potential complications of thyroidectomy makes active surveillance an increasingly recommended management in low‐risk papillary microcarcinomas of the thyroid (PMT). The objective of this study was to report the results of fine needle aspiration (FNA) of nodules ≤ 1 cm with highly suspicious appearance on ultrasonography (US) in patients who are potential candidates for active surveillance.MethodsWe revised thyroid nodules ≤ 1 cm with highly suspicious appearance on US in patients without known distant metastases, suspicion of extrathyroid extension, or suspicious lymph nodes on US. FNA was guided by US. All patients were referred for surgery, except for those with benign cytology (on two occasions).ResultsThere were 181 patients with 198 nodules ≤ 1 cm that were highly suspicious and apparently restricted to the thyroid on US. Initial cytology was benign in 76 nodules (38.4%). Among these 76 nodules, repetition of FNA confirmed the benign nature in 59 (29.8%). Initial cytology was insufficient, indeterminate, suspicious of papillary thyroid cancer (PTC) and malignant (PTC) in 5, 15, 12, 9, and 80 nodules, respectively. FNA revealed medullary carcinoma in one patient. All 90 suspicious or malignant nodules were carcinomas on histology and 22 (81.4%) of the 27 nodules with indeterminate cytology were malignant.ConclusionsFNA changed the “presumptive” diagnosis of PMT in 30% of nodules. Diagn. Cytopathol. 2017;45:294–296. © 2016 Wiley Periodicals, Inc.
The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction
Authors: Nayor Matthew , Larson Martin G. , Wang Na , Santhanakrishnan Rajalakshmi , Lee Douglas S. , Tsao Connie W. , Cheng Susan , Benjamin Emelia J. , Vasan Ramachandran S. , Levy Daniel , Fox Caroline S. , Ho Jennifer E. 
Published: February 2017

AbstractAimsChronic kidney disease (CKD) and microalbuminuria are associated with incident heart failure (HF), but their relative contributions to HF with preserved vs. reduced EF (HFpEF and HFrEF) are unknown. We sought to evaluate the associations of CKD and microalbuminuria with incident HF subtypes in the community‐based Framingham Heart Study (FHS).Methods and resultsWe defined CKD as glomerular filtration rate <60 mL/min/1.73 m2, and microalbuminuria as a urine albumin to creatinine ratio (UACR) ≥17 mg/g in men and ≥25 mg/g in women. We observed 754 HF events (324 HFpEF/326 HFrEF/104 unclassified) among 9889 FHS participants with serum creatinine measured (follow‐up 13 ± 4 years). In Cox models adjusted for clinical risk factors, CKD (prevalence = 9%) was associated with overall HF [hazard ratio (HR) 1.24, 95% confidence interval (CI) 1.01–1.51], but was not significantly associated with individual HF subtypes. Among 2912 individuals with available UACR (follow‐up 15 ± 4 years), 192 HF events (91 HFpEF/93 HFrEF/8 unclassified) occurred. Microalbuminuria (prevalence = 17%) was associated with a higher risk of overall HF (HR 1.71, 95% CI 1.25–2.34) and HFrEF (HR 2.10, 95% CI 1.35–3.26), but not HFpEF (HR 1.26, 95% CI 0.78–2.03). In cross‐sectional analyses, microalbuminuria was associated with LV systolic dysfunction (odds ratio 3.19, 95% CI 1.67–6.09).ConclusionsMicroalbuminuria was associated with incident HFrEF prospectively, and with LV systolic dysfunction cross‐sectionally in a community‐based sample. In contrast, CKD was modestly associated with overall HF but not differentially associated with HFpEF vs. HFrEF. The mechanisms responsible for the relationship of microalbuminuria to future development of HFrEF warrant further investigation.
Electrochemical Selective Determination of Uranyl Ions Using PVC Membrane Sensor
Authors: Akl Zeinab F. 
Published: February 2017

AbstractA UO22+‐PVC membrane electrode was constructed using 2‐thenoyltrifluoroacetone as ionophore and its electrochemical response performance was characterized. The effect of membrane composition on the electrode performance was studied and best results were obtained using dioctylsebacate as a mediator and potassium tetrakis(4‐chlorophenyl)borate as anion excluder. The optimized UO22+‐sensor exhibited a Nernstian response with a slope of 29.5±0.5 mV decade−1 over the concentration range 5.0×10−7−1.0×10−1 mol L−1 at 25 °C with a detection limit of 3.1×10−7 mol L−1. The optimized electrode showed very good selectivity towards UO22+ relative to a wide variety of other cations and fast response time. Surface morphology of the optimized membrane electrode at different stages of its development and use was investigated and discussed. Quantum chemical calculations for geometrical optimization of the ionophore were carried out to investigate the interaction between the ionophore and UO22+ using DFT B3LYP/6‐31++G(d,p) level of theory and the obtained data confirmed the proposed response mechanism. The developed sensor was successfully applied for UO22+ selective determination in real water samples and the obtained results were compared to those obtained by spectrophotometric method indicating no significant difference.
Residual structural capacity evaluation of steel moment‐resisting frames with dynamic‐strain‐based model updating method
Authors: Suzuki Akiko , Kurata Masahiro , Li Xiaohua , Shimmoto Shota 
Published: February 2017

SummaryThis paper presents a method for evaluating the residual structural capacity of earthquake‐affected steel structures. The method first quantifies the damage severity of a beam by computing the dynamic‐strain‐based damage index. Next, the model used to analyze the structure is updated based on the damage index, to reflect the observed damage conditions. The residual structural capacity is then estimated in terms of changes in stiffness and strength, which can be applied by structural engineers, via a nonlinear static analysis of the updated model. The main contributions of this paper are in performance evaluation of the dynamic‐strain‐based damage index for seismically induced damage using a newly developed substructure testing environment, consideration of various damage patterns in composite beams, and extension of a local damage evaluation technique to a residual capacity estimation procedure by incorporating the model‐updating technique. In laboratory testing, the specimens were damaged quasi‐statically, and vibration tests were conducted as the damage proceeded. First, a bare steel beam–column connection was tested, and then a similar one with a floor slab was used for a more realistic case. The estimated residual structural capacities for these specimens were compared with the static test results. The results verified that the proposed method can provide fine estimates of the stiffness and strength deteriorations within 10% for the specimen without the floor slab and within 30% for that with the floor slab. Copyright © 2017 John Wiley & Sons, Ltd.
Is overestimation of body size associated with neuropsychological weaknesses in anorexia nervosa?
Authors: Øverås Maria , Kapstad Hilde , Brunborg Cathrine , Landrø Nils Inge , Rø Øyvind 
Published: February 2017

AbstractBackgroundRecent research indicates some evidence of neuropsychological weaknesses in visuospatial memory, central coherence and set‐shifting in adults with anorexia nervosa (AN). The growing interest in neuropsychological functioning of patients with AN is based upon the assumption that neuropsychological weaknesses contribute to the clinical features of the illness. However, due to a paucity of research on the connection between neuropsychological difficulties and the clinical features of AN, this link remains hypothetical. The main objective of this study was to explore the association between specific areas of neuropsychological functioning and body size estimation in patients with AN and healthy controls.MethodsThe sample consisted of 36 women diagnosed with AN and 34 healthy female controls. Participants were administered the continuous visual memory test and the recall trials of Rey Complex Figure Test to assess visual memory. Central coherence was assessed using the copy trial of Rey Complex Figure Test, and the Wisconsin Card Sorting Test was used to assess set‐shifting. Body size estimation was assessed with a computerized morphing programme.ResultsThe analyses showed no significant correlations between any of the neuropsychological measures and body size estimation.ConclusionThe results suggest that there is no association between these areas of neuropsychological difficulties and body size estimation among patients with AN. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Improvement of moving particle semi‐implicit method for simulation of progressive water waves
Authors: Wang Lizhu , Jiang Qin , Zhang Changkuan 
Published: February 2017

SummaryPrecise simulation of the propagation of surface water waves, especially when involving breaking wave, takes a significant place in computational fluid dynamics. Because of the strong nonlinear properties, the treatment of large surface deformation of free surface flow has always been a challenging work in the development of numerical models. In this paper, the moving particle semi‐implicit (MPS) method, an entirely Lagrangian method, is modified to simulate wave motion in a 2‐D numerical wave flume preferably. In terms of consecutive pressure distribution, a new and simple free surface detection criterion is proposed to enhance the free surface recognition in the MPS method. In addition, a revised gradient model is deduced to diminish the effect of nonuniform particle distribution and then to reduce the numerical wave attenuation occurring in the original MPS model. The applicability and stability of the improved MPS method are firstly demonstrated by the calculation of hydrostatic problem. It is revealed that these modifications are effective to suppress the pressure oscillation, weaken the local particle clustering, and boost the stability of numerical algorithm. It is then applied to investigate the propagation of progressive waves on a flat bed and the wave breaking on a mild slope. Comparisons with the analytical solutions and experimental results indicate that the improved MPS model can give better results about the profiles and heights of surface waves in contrast with the previous MPS models. Copyright © 2017 John Wiley & Sons, Ltd.
The association of a heart attack or stroke with depressive symptoms stratified by the presence of a close social contact: findings from the National Health and Aging Trends Study Cohort
Authors: Simning Adam , Seplaki Christopher L. , Conwell Yeates 
Published: February 2017

ObjectiveThe objective of the study is to examine whether the risk of having clinically significant depressive symptoms following a heart attack or stroke varies by the presence of a close social contact.MethodsThe National Health and Aging Trends Study is a nationally representative longitudinal survey of US Medicare beneficiaries aged 65 and older initiated in 2011. A total of 5643 older adults had information on social contacts at baseline and depressive symptoms at the 1‐year follow‐up interview. The two‐item Patient Health Questionnaire identified clinically significant depressive symptoms. Interview questions examined social contacts and the presence of self‐reported heart attack or stroke during the year of follow‐up.ResultsA total of 297 older adults reported experiencing a heart attack and/or stroke between their baseline and follow‐up interviews. In regression analyses accounting for sociodemographics, baseline depressive symptoms, medical comorbidity, and activities of daily living impairment, older adults with no close social contacts had increased odds of depressive symptoms at follow‐up after experiencing a heart attack or stroke, while those with close social contacts had increased odds of depressive symptoms at follow‐up after experiencing a stroke, but not a heart attack.ConclusionsOlder adults have increased odds of having depressive symptoms following a self‐reported stroke, but only those with no close social contacts had increased odds of depressive symptoms following a heart attack. Social networks may play a role in the mechanisms underlying depression among older adults experiencing certain acute health events. Future work exploring the potential causal relationships suggested here, if confirmed, could inform interventions to alleviate or prevent depression among at risk older adults. Copyright © 2017 John Wiley & Sons, Ltd.
An Analysis of Sibling Correlations in Health using Latent Variable Models
Authors: Halliday Timothy J. , Mazumder Bhashkar 
Published: February 2017

AbstractWe investigate sibling correlations in youth health status using the Panel Study of Income Dynamics. We do so by estimating the covariance structure of a system of equations in latent variables using methods that have hitherto not been used in the literature on intergenerational transmissions of health. Across a battery of outcomes, we find that between 50 and 60% of health status can be attributed to shared familial or neighborhood characteristics. Taking the principal component across all outcomes, we obtain a sibling correlation of about 53%. These estimates, which are larger than previous estimates of sibling correlations in health that rely on linear models, are more in‐line with sibling correlations in income and suggest that health status, like other measures of socioeconomic success, is strongly influenced by family background. Copyright © 2017 John Wiley & Sons, Ltd.
N‐glycan in cockroach allergen regulates human basophil function
Authors: Do Danh C. , Yang Shuang , Yao Xu , Hamilton Robert G. , Schroeder John T. , Gao Peisong 
Published: February 2017

AbstractIntroductionCockroach allergen exposure elicits cockroach sensitization and poses an increased risk for asthma. However, the major components in cockroach allergen and the mechanisms underlying the induction of cockroach allergen‐induced allergy and asthma remain largely elusive. We sought to examine the role of cockroach‐associated glycan in regulating human basophil function.MethodsN‐linked glycans from naturally purified cockroach allergen Bla g 2 were characterized by MALDI‐TOF mass spectrometry. Binding of cockroach allergen to serum IgE from cockroach allergic subjects was determined by solid‐phase binding immunoassays. Role of cockroach associated glycan in histamine release and IL‐4 production from human basophils was examined. Expression of C‐type lectin receptors (CLRs) and their role in mediating glycan‐uptake in the basophils was also investigated.ResultsMALDI‐TOF mass spectrometric analysis of N‐glycan from Bla g 2 showed complex hybrid‐types of glycans that terminated with mannose, galactose, and/or N‐acetyl glucosamine (GlcNAc). Deglycosylated Bla g 2 showed reduced binding to IgE and was less capable of inducing histamine release from human basophils. In contrast, N‐glycan derived from Bla g 2 significantly inhibited histamine release and IL‐4 production from basophils passively sensitized with serum from cockroach allergic subjects. An analysis of CLRs revealed the expression of DC‐SIGN and DCIR, but not MRC1 and dectin‐1, in human basophils. Neutralizing antibody to DCIR, but not DC‐SIGN, significantly inhibited Bla g 2 uptake by human basophils. A dose‐dependent bindings of cockroach allergen to DCIR was also observed.ConclusionsThese observations indicate a previously unrecognized role for cockroach allergen‐associated glycans in allergen‐induced immune reactions, and DCIR may play a role in mediating the regulation of glycan on basophil function.