bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of EGFR, KRAS and BRAF mutations in metastatic cells from cerebrospinal fluid
Authors: Frankel Diane , Nanni-Metellus Isabelle , Robaglia-Schlupp Andrée , Tomasini Pascale , Guinde Julien , Barlesi Fabrice , Astoul Philippe , Ouafik L’Houcine , Amatore Florent , Secq Véronique , Kaspi Elise , Roll Patrice 
Published: January 2018

AbstractBackground:In lung adenocarcinoma, molecular profiling of actionable genes has become essential to set up targeted therapies. However, the feasibility and the relevance of molecular profiling from the cerebrospinal fluid (CSF) in the context of meningeal metastasis have been poorly assessed.Methods:We selected patients with stage IV lung adenocarcinoma harbouring metastatic cells in the CSF after cytological analysis. Seven samples from six patients were eligible for molecular testing of epidermal growth factor receptor (EGFR), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue (KRAS), v-Raf murine sarcoma viral oncogene homologue B1 (BRAF) and human epidermal growth factor receptor 2 (HER2) mutations using quantitative polymerase chain reaction (PCR) high-resolution melting curve analysis and Sanger sequencing after DNA extraction from the cell pellets of the CSF.Results:Five patients showed mutations in one or two actionable genes, two harboured anEGFRmutation (exons 19 and 21), one only aKRASmutation, one bothEGFRandKRASmutations and one aBRAFmutation. In all cases, the results of mutation testing provided new major information for patient management, leading to therapeutic adaptation. CSF molecular analysis identified mutations not detected in other neoplastic sites for two patients. In one case, the EGFR p.Thr790Met was identified. CSF was also the only sample available for genetic testing for almost all patients at the time of disease progression.Conclusions:When cancer cells are present in the CSF, the molecular profiling from the cell pellets is relevant, as it can detect supplemental or different mutations compared to a previous analysis of the primitive tumour or plasma cell-free DNA and allows the adaptation of the treatment strategy.
LC-MSMS assays of urinary cortisol, a comparison between four in-house assays
Authors: Brossaud Julie , Leban Monique , Corcuff Jean-Benoit , Boux de Casson Florence , Leloupp Anne-Gaëlle , Masson Damien , Moal Valérie , Bach-Ngohou Kalyane 
Published: January 2018

Abstract

Background:
Twenty-four hour urinary free cortisol (UFC) determination can be used for screening and follow-up of Cushing syndrome (CS). As immunoassay methods lack specificity for UFC measurement, the use of high-performance liquid chromatography coupled to mass spectrometer (LC-MSMS) is recommended. The aim of our study was to compare UFC results using four LC-MSMS methods performed in four independent laboratories in order to evaluate interlaboratory agreement.

Methods:
Frozen aliquots of 24-h urine samples (78 healthy volunteers and 20 patients with CS) were sent to four different laboratories for analysis. Following liquid-liquid or solid-liquid extraction, UFC were determined using four different LC-MSMS assay.

Results:
UFC intra- and interassays variation coefficients were lower than 10% for each centre. External quality control results were not significantly different. UFC normal ranges (established from healthy volunteers) were 17–126, 15–134, 12–118 and 27–157 nmol/day, respectively. Classification of UFC from healthy volunteers and patients with CS using a 95th percentile threshold was similar. However, for extreme UFC values (<50 or >270 nmol/day), negative or positive bias was noted.

Conclusions:
Even for highly specific methods such as LC-MSMS, variations of results can be found depending on analytical process. Validation of LC-MSMS methods including determination of the reference range is essential.
Verb-argument constructions in advanced L2 English learner production: Insights from corpora and verbal fluency tasks
Authors: Römer Ute , Skalicky Stephen C. , Ellis Nick C. 
Published: January 2018

AbstractThis paper draws on data from learner and native-speaker corpora as well as psycholinguistic data to gain insights into second language speaker knowledge of English verb-argument constructions (VACs). For each of 34 VACs, L1 German and L1 Spanish advanced English learners’ and English native speakers’ dominant verb–VAC associations are examined based on data retrieved from the International Corpus of Learner English (ICLE), the Louvain International Database of Spoken English Interlanguage (LINDSEI), their respective Native Speaker (NS) reference corpora, and data collected in verbal fluency tasks in which participants complete VAC frames, such as, ‘she _______ with the…’ with verbs that come to mind. We compare findings from the different data sets and consider the strengths and limitations of each in relation to questions in usage-based second language acquisition and Construction Grammar.
Corporate environmental information system data storage development and management (Environmental Information System)
Authors: Lyazat Naizabayeva , Chingiz Nurzhanov , Zhassulan Orazbekov , Gulnara Tleuberdiyeva 
Published: January 2018

Abstract
In this article a software implementation of the environmental monitoring is developed and presented, which is responsible for receive, store, process and analysis of data. For logical database design system Computer- Aided Software Engineering (CASE) technology, the AllFusion ERwin Data Modeler was selected. To develop corporate Oracle database management system used. The database contains a set of objects, which store all the primary and additional service information, as well as a set of software modules of business logic. The developed information system makes it possible to find optimal solutions for clean and disposal of the contaminated areas. There are advantages of created databases on the areas to be remediated, such as the analysis of remediation made by using plants.
Self-Extinguishing and Non-Drip Flame Retardant Polyamide 6 Nanocomposite: Mechanical, Thermal, and Combustion Behavior
Authors: Wu Hao , Ortiz Rogelio , Correa Renan De Azevedo , Krifa Mourad , Koo Joseph H. 
Published: January 2018

AbstractIncorporation of flame-retardant (FR) additives and nanoclay fillers into thermoplastic polymers effectively suppresses materials flammability and melt dripping behavior. However, it largely affects other properties, such as toughness and ductility. In order to recover the lost toughness and ductility of flame retardant polyamide 6, various loadings of maleic anhydride modified SEBS elastomer were added and processed by twin screw extrusion. TEM images showed exfoliated nanoclay platelets and reveals that the clay platelets well dispersed in the polymer matrix. By balancing the ratio of flame retardants, nanoclay and elastomers, formulation with elongation at break as high as 76% was achieved. Combining conventional intumescent FR and nanoclay, UL-94 V-0 rating and the LOI value as high as 32.2 were achieved. In conclusion, effective self-extinguishing and non-drip polyamide 6 nanocomposite formulations with significant improvement in toughness and ductility were achieved.
On the Classification of Networks Self–Similarly Moving by Curvature
Authors: Baldi Pietro , Haus Emanuele , Mantegazza Carlo 
Published: January 2018

AbstractWe give an overview of the classification of networks in the plane with at most two triple junctions with the property that under the motion by curvature they are self-similarly shrinking. After the contributions in [7, 9, 20], such a classification was completed in the recent work in [4] (see also [3]), proving that there are no self-shrinking networks homeomorphic to the Greek “theta” letter (a double cell) embedded in the plane with two triple junctions with angles of 120 degrees. We present the main geometric ideas behind the work [4]. We also briefly introduce our work in progress in the higher-dimensional case of networks of surfaces in R
Status of Violence in a Selected Faculty: The Students’ Experience
Authors: Fathi Mohammad , Fallahi Arezoo , Sharifi Salar , Dehghani Shoaib , Olyaei Nazila , Valiee Sina 
Published: January 2018

AbstractThe present study is aimed at examining the status of violence among the students of nursing, midwifery, and operating room. A self-reporting questionnaire with two sections of demographic characteristics and experience of violence was used. The data obtained were analyzed, using SPSS software. 58.7 percent of the students had a history of violence in the previous year. The maximum percentage of violence exposure belonged to the students of operating room (76.9%). The highest incidence of violence was verbal (76.4%), happened in patients’ rooms (32.9%) and was in the form of insult (75.1%). Accordingly, preventive actions are required to prevent and control violence and support students. Informing students about violence, communicative skills, reaction, and coping with violence during studying is necessary. Therefore, educational authorities and theoretical and clinical instructors should take appropriate measures in order to prevent violence and create supportive mechanisms for the students.
Analytical and numerical approach to defining the stability region of a dynamical system
Authors: Neštický M. , Palumbíny O. , Michalčonok G. 
Published: January 2018

Abstract
The paper presents two different approaches to estimating the region of stability of differential equation. Estimation of the region of stability is an essential practice in relation to control of the dynamical system. In this paper the objects of examination are differential equations with quasi-derivation. The equations have features that do not allow the application of classical methods for establishing stability. The goal is to compare the results of an analytic approach using Lyapunov method and computer simulation using a numerical method. The brief description of both methods are introduced and graphical results are presented and compared
Clinical study of fetal neurobehavior by the KANET test
Authors: Moreira Neto Raul , Porovic Selma 
Published: January 2018

AbstractFetal neurology is evolving as an area of great interest in prenatal diagnosis and fetal medicine. The identification and diagnosis of brain damage prenatally has been a great challenge in obstetrics for many years. Investigations of fetal behavior in comparison with morphological studies led to the conclusion that fetal behavioral patterns directly reflect developmental and maturational processes of the fetal central nervous system (CNS). Four-dimensional (4D) ultrasound has greatly improved the assessment of the quality of the fetal spontaneous movements, and enabled a better evaluation of fetal behavior. The assessment of normal neurobehavioral development by 4D ultrasound provided the opportunity to investigate functional characteristics of the fetus that could predict neurological developmental dysfunction. Some studies have already been carried out to evaluate this new methodology in the observation of fetal behavior during different stages of gestation, in an attempt to better understand the relationships between the maturation of the CNS of the fetus and its implications on its behavior pattern. We present a review of literature on fetal behavior by 4D ultrasound.
Spatio-Temporal Characteristics of the Bluetongue Epizooty in the Balkan Peninsula from 2014 to February 2015
Authors: Stojmanovski Zharko , Tabakovski Blagojcho 
Published: January 2018

Abstract
Starting in May 2014 an emerging Bluetongue (BT) serotype 4 (BTV-4) epizooty has affected the ruminant population of eleven countries from the Balkan Peninsula. Consequently, the veterinary services implemented various bio-security measures and a considerable discussion has been raised if future BTV surveillance and preventive measures should be taken in risk based zones and periods. Therefore, the objective of this work was to describe the spatial and temporal characteristics of the BTV-4 epizooty in the Balkan Peninsula from May 2014 to February 2015. We used the space-time permutation model of the scan statistic to identify the space-time disease clusters. The scan statistic was parameterized to a maximum temporal length of 150 days (duration of the epizooty in the Balkans in 2014) and a radius of 100 km as a maximum spatial cluster size (protection zone for BT). Results were significant (p < 0.05) to the maximum spatial size defined for the clusters. From the 6295 BT outbreaks the scan statistics identified 33 disease clusters in nine Balkan countries. The highest number of outbreaks occurred from September to November 2014.The earliest cluster was detected in Greece in July 2014 with a radius of 56 km. The latest cluster was detected in Croatia in February 2015 with a radius of 99,8 km. These results are a first description of the spatial and temporal characteristics of the 2014-February 2015 BT epizooty in the Balkans.
Socio-demographic and lifestyle determinants of loyalty program participation in the Czech Republic
Authors: Formánek Tomáš , Tahal Radek 
Published: January 2018

Abstract
Loyalty programs are among the most frequently employed marketing tools used to minimize customer attrition rates. In this article, different aspects of consumer participation in loyalty programs for major product categories are analyzed with focus on generational differences. We use the time-proven segmentation of Baby boomers and generations X, Y and Z. Our analyses and findings are based on primary data (2016): the survey is formed by a representative sample of 585 respondents. A wide portfolio of statistical learning methods and tests is used for data analysis. The first segment of our analysis brings forward groups of product categories where consumers tend to use loyalty programs concurrently. This identifies opportunities and boundaries for establishing and managing co-branded loyalty programs. The second part of our quantitative analysis is based on generational, other socio-demographic and lifestyle factors influencing individual participation in loyalty programs. Here, the main focus is on four product categories where loyalty programs are used most often. Generational differences are well pronounced in fashion-related categories. On the other hand, loyalty program usage rates in product categories related to basic household operations show little generational differences.
Gliotransmitters and cytokines in the control of blood-brain barrier permeability
Authors: Osipova Elena D. , Semyachkina-Glushkovskaya Oxana V. , Morgun Andrey V. , Pisareva Natalia V. , Malinovskaya Natalia A. , Boitsova Elizaveta B. , Pozhilenkova Elena A. , Belova Olga A. , Salmin Vladimir V. , Taranushenko Tatiana E. , Noda Mami , Salmina Alla B. 
Published: January 2018

AbstractThe contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.
Non-linear Dynamics and Exact Solutions for the Variable-Coefficient Modified Korteweg–de Vries Equation
Authors: Liu Jiangen , Zhang Yufeng 
Published: January 2018

Abstract
This paper presents some new exact solutions which contain soliton solutions, breather solutions and two types of rational solutions for the variable-coefficient-modified Korteweg–de Vries equation, with the help of the multivariate transformation technique. Furthermore, based on these new soliton solutions, breather solutions and rational solutions, we discuss their non-linear dynamics properties. We also show the graphic illustrations of these solutions which can help us better understand the evolution of solution waves.
Effects of a 6-Week Bench Press Program Using the Freak Bar in a Sample of Collegiate Club Powerlifters
Authors: Ghigiarelli Jamie J. , Pelton Luke M. , Gonzalez Adam M. , Fulop Andras M. , Gee Joshua Y. , Sell Katie M. 
Published: January 2018

Abstract
Ghigiarelli, JJ, Pelton, LM, Gonzalez, AM, Fulop, AM, Gee, JY, and Sell, KM. Effects of a 6-week bench press program using the freak bar in a sample of collegiate club powerlifters. J Strength Cond Res 32(4): 938–949, 2018—Powerlifters train using specialty bars for unstable load (UL) training. For the bench press, the acute effects of UL are mixed, with few studies that examine training interventions. The purpose of this study was to examine the effects of a 6-week bench press training program that uses the Freak Bar (FB) as compared to a traditional barbell (TB) on maximum bench press, peak force, and peak impulse. Seven men and 3 women (21 ± 2.0 years, 172.2 ± 2.9 cm, and 95.3 ± 20.3 kg) were required to bench press 2 days per week as part of a structured program. On the second bench press day, the FB and TB groups performed 3-position pause bench presses at 60–70% one repetition maximum (1RM). One repetition maximum, peak force, and peak impulse were measured before test and after test after the 6-week program. Peak force and peak impulse were tested at 3 bench positions, including the presticking, sticking, and poststicking points, defined by the distance of the barbell from the chest. Posttraining 1RM for the FB group and TB group increased 6.7% (6.78 ± 1.6 kg, p = 0.006) and 4.3% (4.5 ± 2.7 kg, p = 0.23), respectively, with no significant differences between the groups (p = 0.589, η

p

2 = 0.044). There were no significant differences between the groups at each bench position for peak force (p = 0.606) or peak impulse (p = 0.542). Freak Bar can be an alternative for improving maximum strength and peak force but is not significantly better than TB training when performing the 3-position pause bench press.
Signal Complexity of Human Intracranial EEG Tracks Successful Associative-Memory Formation across Individuals
Authors: Sheehan Timothy C. , Sreekumar Vishnu , Inati Sara K. , Zaghloul Kareem A. 
Published: January 2018

Memory performance is highly variable among individuals. Most studies examining human memory, however, have largely focused on the neural correlates of successful memory formation within individuals, rather than the differences among them. As such, what gives rise to this variability is poorly understood. Here, we examined intracranial EEG (iEEG) recordings captured from 43 participants (23 male) implanted with subdural electrodes for seizure monitoring as they performed a paired-associates verbal memory task. We identified three separate but related signatures of neural activity that tracked differences in successful memory formation across individuals. High-performing individuals consistently exhibited less broadband power, flatter power spectral density slopes, and greater complexity in their iEEG signals. Furthermore, within individuals across three separate time scales ranging from seconds to days, successful recall was positively associated with these same metrics. Our data therefore suggest that memory ability across individuals can be indexed by increased neural signal complexity.SIGNIFICANCE STATEMENTWe show that participants whose intracranial EEG exhibits less low-frequency power, flatter power spectrums, and greater sample entropy overall are better able to memorize associations, and that the same metrics track fluctuations in memory performance across time within individuals. These metrics together signify greater neural signal complexity, which may index the brain's ability to flexibly engage with information and generate separable memory representations. Critically, the current set of results provides a unique window into the neural markers of individual differences in memory performance, which have hitherto been underexplored.
Composing Authority in Six Forged “Haydn” Sonatas
Authors: Reece Frederick 
Published: January 2018

In December 1993 news broke that six keyboard sonatas whose rediscovery was being hailed as “The Haydn Scoop of the Century” were, in fact, not by Haydn at all. It soon emerged that the compositions—initially believed to be the lost Hob. XVI:2a–e and 2g—were not simple misattributions, but rather something that has rarely been discussed in the music world: modern forgeries deliberately constructed to deceive scholars and listeners.
Adapting philosophical and art-historical writing on forgery to music, this article examines the six “Haydn” sonatas in the context of contemporary debates about expertise, postmodernism, and the author concept. Analyzing the stylistic content of the works in question sheds new light on musical forgeries as artifacts of aesthetic prejudice and anti-academic critique. More broadly, it suggests that the long-overlooked phenomenon of forgery poses questions about authorship, authority, and truth itself that have an important place in our shared history as musicologists.
Should our standards of evidence be rooted in historical sources, musical style, or some combination of the two? What kind of relationship do we believe exists between composers and their works? And is there any inherent reason—cultural, ethical, or otherwise—that we cannot write music like Haydn’s today? In posing such questions, the story of the forged Haydn sonatas provides us with a unique opportunity to reflect on the values and future of the field.