bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the V‐RESOLVE (Visual Estimation for Risk prEdiction of Side Branch OccLusion in Coronary Bifurcation interVEntion) score system
Authors: He Yuan , Zhang Dong , Yin Dong , Zhu Chen'gang , Feng Lei , Song Chenxi , Chen Changzhe , Xu Bo , Dou Kefei 
Published: January 2018

AbstractObjectivesThis study sought to validate the V‐RESOLVE score system.BackgroundThe V‐RESOLVE score was developed to predict the risk of side branch (SB) occlusion after stenting in the main vessel (MV) of coronary bifurcation lesions based on visual estimation of the angiographic data, but it needed to be validated.MethodsFrom January to June 2013, 1,286 patients with 1,820 bifurcation lesions undergoing elective intervention with provisional strategy were included. Angiographic data before MV stenting were reviewed, and the V‐RESOLVE score was calculated. SB occlusion was defined as any decrease in thrombolysis in myocardial infarction (TIMI) flow grade or the absence of flow in the SB after MV stenting. The statistical performance of the prediction model was assessed by its discrimination, calibration, and clinical usefulness.ResultsSB occlusion occurred in 222 (12.20%) of 1,820 bifurcation lesions. The discrimination of the V‐RESOLVE score for the validation cohort was good [C‐statistic: 0.80, 95% confidence interval (CI) 0.77–0.84]. Regarding calibration performance, the calibration‐in‐the‐large was −0.03 (95% CI: −0.181 to 0.12), while the combined predictive effect was slightly enlarged (calibration slope: 1.25, 95% CI: 1.081–1.41) and, mainly attributed to the stronger predictive effect of the diameter stenosis of the SB before MV stenting. Stratified by the V‐RESOLVE score, the SB occlusion rate was significantly higher in the high‐risk group (26.18%) than in the non‐high‐risk group (3.48%).ConclusionsThe V‐RESOLVE score system is a useful tool to help risk prediction for SB occlusion and decision‐making in bifurcation intervention.
The “double stingray technique” for recanalizing chronic total occlusions with bifurcation at the distal cap
Authors: Tajti Peter , Doshi Darshan , Karmpaliotis Dimitri , Brilakis Emmanouil S. 
Published: January 2018

AbstractAntegrade dissection re‐entry is often discouraged for chronic total occlusions (CTOs) with a bifurcation at the distal cap due to risk of side branch occlusion that can lead to periprocedural myocardial infarction and incomplete revascularization. Antegrade dissection re‐entry, however, is often needed, especially in complex cases. We present the novel “double Stingray technique” for CTOs involving bifurcations, in which the Stingray system is used twice for re‐entry into both vessel branches, followed by two‐stent bifurcation stenting to maintain the patency of both branches.
Incidence, predictors, and midterm clinical outcomes of left ventricular obstruction after transcatheter aortic valve implantation
Authors: Tsuruta Hikaru , Hayashida Kentaro , Yashima Fumiaki , Yanagisawa Ryo , Tanaka Makoto , Arai Takahide , Minakata Yugo , Itabashi Yuji , Murata Mitsushige , Kohsaka Shun , Maekawa Yuichiro , Takahashi Tatsuo , Yoshitake Akihiro , Shimizu Hideyuki , Fukuda Keiichi 
Published: January 2018

AbstractObjectivesWe aimed to evaluate the incidence and midterm clinical outcomes of left ventricular obstruction (LVO) after transcatheter aortic valve implantation (TAVI).BackgroundsLVO is occasionally unmasked following valve replacement for severe aortic stenosis. However, little is known about the prevalence and effects of LVO after TAVI.MethodsA total of 158 patients who underwent TAVI in our center between October 2013 and November 2015 received echocardiographic evaluations at baseline; before hospital discharge; and at 3, 6, and 12 months after TAVI. LVO was defined as a peak pressure gradient >30 mm Hg.ResultsOver 1 year of follow‐up after TAVI, 21 patients (13.3%) demonstrated postprocedural LVO. The incidence was highest at 3‐months follow‐up and decreased at 6 months or later. Of the 21 patients with LVO, 20 (95.2%) demonstrated midventricular obstruction (MVO), whereas only 1 (4.8%) showed obstruction of the outflow tract (LVOT) with systolic anterior motion (SAM) of the mitral leaflet. In a multivariate analysis, the LVOT diameter (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.30–0.67; P < 0.001), transvalvular velocity (OR, 2.44; 95% CI, 1.13–5.26; P = 0.023), and the presence of accelerated intraventricular flow at baseline (OR, 6.13; 95% CI, 1.49–25.2; P = 0.012) were associated with the occurrence of LVO. Postprocedural LVO was not associated with midterm all‐cause death or heart failure events.ConclusionIn patients who underwent TAVI, MVO occurred more often than LVOT obstruction. However, the occurrence of postprocedural LVO was not associated with worsened clinical outcomes in these patients.
High‐Voltage Li2SiO3−LiNi0.5Mn1.5O4 Hollow Spheres Prepared through In Situ Aerosol Spray Pyrolysis towards High‐Energy Li‐Ion Batteries
Authors: Wang Jiang , Nie Ping , Jiang Jiangmin , Wu Yuting , Fu Ruirui , Xu Guiyin , Zhang Yadi , Dou Hui , Zhang Xiaogang 
Published: January 2018

AbstractHigh‐voltage Li2SiO3‐composited LiNi0.5Mn1.5O4 hollow spheres synthesized through a scalable in situ aerosol spray pyrolysis process combined with short‐term high‐temperature calcination are investigated as an ultralong‐life cathode for high‐energy Li‐ion batteries. The phase structure, morphology, and valence state of the LiNi0.5Mn1.5O4/Li2SiO3 composites are investigated by using X‐ray diffraction, electron microscopy, and X‐ray photoelectron spectroscopy. The three‐dimensional Li‐ion conductor Li2SiO3 can effectively enhance the Li+ diffusion rate, alleviate the side reactions, and reduce the formation of a solid electrolyte interphase (SEI) as a protective layer between the LiNi0.5Mn1.5O4 electrode and electrolyte interfaces. Li2SiO3‐composited LiNi0.5Mn1.5O4 has a better rate and cycling performance, especially long cycling performance. After 500 cycles at 25 °C at 1 C, the capacity retention of the composite is 93.28 %, and the capacity retention is 81.23 % after 400 cycles at 50 °C at 1 C rate. The excellent long cycling and capacity retention indicate that the three‐dimensional Li‐ion conductor Li2SiO3 composite with LiNi0.5Mn1.5O4 is a promising material for high‐energy Li‐ion batteries.
Axially chiral Ni(II) complexes of α‐amino acids: Separation of enantiomers and kinetics of racemization
Authors: Zhang Wenzhong , Ekomo Romuald Eto , Roussel Christian , Moriwaki Hiroki , Abe Hidenori , Han Jianlin , Soloshonok Vadim A. 
Published: January 2018

AbstractHerein we present design, synthesis, chiral HPLC resolution, and kinetics of racemization of axially chiral Ni(II) complexes of glycine and di‐(benzyl)glycine Schiff bases. We found that while the ortho‐fluoro derivatives are configurationally unstable, the pure enantiomers of corresponding axially chiral ortho‐chloro‐containing complexes can be isolated by preparative HPLC and show exceptional configurational stability (t1/2 from 4 to 216 centuries) at ambient conditions. Synthetic implications of this discovery for the development of new generation of axially chiral auxiliaries, useful for general asymmetric synthesis of α‐amino acids, are discussed.
Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1
Authors: Mahtal Nassim , Brewee Clémence , Pichard Sylvain , Visvikis Orane , Cintrat Jean‐Christophe , Barbier Julien , Lemichez Emmanuel , Gillet Daniel 
Published: January 2018

AbstractCytotoxic necrotizing factor 1 (CNF1) is a toxin produced by pathogenic strains of Escherichia coli responsible for extra‐intestinal infections. CNF1 deamidates Rac1, thereby triggering its permanent activation and worsening inflammatory reactions. Activated Rac1 is prone to proteasomal degradation. There is no targeted therapy against CNF1, despite its clinical relevance. In this work we developed a fluorescent cell‐based immunoassay to screen for inhibitors of CNF1‐induced Rac1 degradation among 1120 mostly approved drugs. Eleven compounds were found to prevent CNF1‐induced Rac1 degradation, and five also showed a protective effect against CNF1‐induced multinucleation. Finally, lasalocid, monensin, bepridil, and amodiaquine protected cells from both diphtheria toxin and CNF1 challenges. These data highlight the potential for drug repurposing to fight several bacterial infections and Rac1‐based diseases.
Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis
Authors: Schindler Philipp , Kupcinskas Juozas , Juzenas Simonas , Skieceviciene Jurgita , Salteniene Violeta , Schulz Christian , Weigt Jochen , Malfertheiner Peter , Link Alexander 
Published: January 2018

BACKGROUNDPeritoneal carcinomatosis (PCA) has a prognostic role in patients with gastrointestinal cancers. The differential diagnosis may be challenging due to the low sensitivity of cytology. Although microRNAs (miRNAs) have been a focus of various specimens and diseases, to the best of the authors' knowledge only limited knowledge exists regarding ascites. Herein, the authors systematically evaluated preanalytical factors and the potential of miRNAs as biomarkers of ascites.METHODSThe authors prospectively analyzed samples from patients with PCA, spontaneous bacterial peritonitis (SBP), and portal hypertension (no SBP/PCA). Various preanalytical factors such as extraction kits, sample storage, stability, and processing were systematically evaluated. MiRNA expression profiling using TaqMan Low Density Array and quantitative reverse transcriptase‐polymerase chain reaction were used to evaluate miRNA expression.RESULTSAll selected miRNAs were found to be reliably detectable in ascites samples. Ascites miRNAs were well preserved from degradation with required short‐term and long‐term stability. MiRNA expression profiling in patients with PCA compared with those with no SBP/PCA revealed miR‐21, miR‐186, miR‐222, and miR‐483‐5p to be upregulated and miR‐26b to be downregulated. MiRNA expression validation analysis confirmed higher expression levels of miR‐21 and miR‐186 in patients with PCA compared with those with no SBP/PCA, whereas miR‐223 was significantly upregulated in patients with SBP. A simple proportion score between miR‐21 and miR‐223 allowed the authors to discriminate between the patients with PCA and those with SBP with an area under the curve of 0.982 (95% confidence interval, 0.943‐1.022).CONCLUSIONSThe data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA‐based molecular approach for the differential diagnosis of PCA. Cancer Cytopathol 2018;126:353‐63. © 2018 American Cancer Society.
When words matter: A “suspicious” urinary tract cytology diagnosis improves patient follow‐up among nonurologists
Authors: Fite J. Judd , Rosenthal Dorothy L. , VandenBussche Christopher J. 
Published: January 2018

BACKGROUNDUrinary tract cytology (UTC) specimens diagnosed using high‐risk indeterminate categories such as “atypical urothelial cells, cannot exclude high‐grade urothelial carcinoma” (AUC‐H) or “suspicious for high‐grade urothelial carcinoma” (SHGUC) have a high rate of detection of high‐grade urothelial carcinoma on subsequent biopsy. Although urologists are familiar with such terminology, it is unclear whether patients receive appropriate follow‐up when UTC is ordered by nonurologists. In the current study, the authors investigated whether the use of AUC‐H versus SHGUC altered patient management among nonurologists.METHODSSpecimens signed out as AUC‐H or SHGUC were identified from the archives of the study institution, which included periods of time before the use of the standardized Johns Hopkins Hospital template, during use of the Johns Hopkins Hospital template, and after institution of The Paris System for Reporting Urinary Cytology.RESULTSApproximately one‐half of the specimens diagnosed as AUC‐H were not investigated further when ordered by nonurologists. Patients with specimens diagnosed as AUC‐H received fewer subsequent biopsies (14% vs 53%; P < .001) when the specimens were ordered by nonurologists versus urologists, despite having similar rates of high‐grade urothelial carcinoma on follow‐up biopsy (67% vs 66%). When specimens ordered by nonurologists were diagnosed as SHGUC, these patients received more follow‐up (100%) compared with those whose specimens were diagnosed as AUC‐H (44%; P < .001). Patients with specimens ordered by nonurologists also received more follow‐up biopsies when these were diagnosed as suspicious (60%) compared with patients whose specimens were diagnosed as AUC‐H (14%; P < .001).CONCLUSIONSUse of the word “suspicious” for the high‐risk indeterminate category results in greater follow‐up among nonurologists ordering UTC specimens. Cancer Cytopathol 2018;126:282‐8. © 2018 American Cancer Society.
Assessment of mechanical properties of human head tissues for trauma modelling
Authors: Lozano‐Mínguez Estívaliz , Palomar Marta , Infante‐García Diego , Rupérez María José , Giner Eugenio 
Published: January 2018

AbstractMany discrepancies are found in the literature regarding the damage and constitutive models for head tissues as well as the values of the constants involved in the constitutive equations. Their proper definition is required for consistent numerical model performance when predicting human head behaviour, and hence skull fracture and brain damage. The objective of this research is to perform a critical review of constitutive models and damage indicators describing human head tissue response under impact loading. A 3D finite element human head model has been generated by using computed tomography images, which has been validated through the comparison to experimental data in the literature. The threshold values of the skull and the scalp that lead to fracture have been analysed. We conclude that (1) compact bone properties are critical in skull fracture, (2) the elastic constants of the cerebrospinal fluid affect the intracranial pressure distribution, and (3) the consideration of brain tissue as a nearly incompressible solid with a high (but not complete) water content offers pressure responses consistent with the experimental data.
Ferrocenyl GNA Nucleosides: A Bridge between Organic and Organometallic Xeno‐nucleic Acids
Authors: Skiba Joanna , Yuan Qing , Hildebrandt Alexander , Lang Heinrich , Trzybiński Damian , Woźniak Krzysztof , Balogh Ria K. , Gyurcsik Béla , Vrček Valerije , Kowalski Konrad 
Published: January 2018

AbstractThe enantioselective synthesis and electrochemistry of the first ferrocenyl GNA nucleosides is reported. These compounds were obtained by a Sharpless asymmetric dihydroxylation reaction of [3‐(N1‐thyminyl)‐1‐(ferrocenyl)]propene as S,R and R,S enantiomers in about 70 % yield with enantiomeric excesses of >99 % and 71 %, respectively. The absolute configurations of the chiral carbon atoms in the nucleosides were assigned by single‐crystal X‐ray diffraction analysis of the methyl derivatives in the solid state. The compounds were also studied with circular dichroism (CD) spectroscopy in solution. The enantiomeric relationship between the S,R and R,S isomers was confirmed by the near‐mirror‐image CD spectra. The redox properties of the nucleosides and their methylated derivatives were investigated using cyclic voltammetry. The cyclic voltammograms revealed reversible redox processes for the entire series of compounds at potentials of −25 mV (for nonmethylated derivatives) and 75 mV (for methylated derivatives) versus the ferrocene/ferrocenium reference redox couple.
Queuing loss models with more alternative heterogeneous groups
Authors: Bakmaz Bojan , Bojkovic Zoran , Bakmaz Miodrag 
Published: January 2018

SummaryThis paper considers queuing model with 2 Poisson traffics offered to the primary group, where the rejected demands of one of them are overflowed to the alternative groups in sequence and leave the system without being served when all channels are busy. Here, serving intensity from primary group is changed and gets various values in alternative groups. Generating function technique is used for the analytical solution of steady‐state equations system. Common solution obtained for the state probabilities permits efficient procedure for model parameters calculation. Next, explicit solutions in the case with secondary and tertiary groups are derived. Moreover, obtained solutions for binomial moments are of significant importance for treating more complex models. Some numerical results are also presented through illustrative examples justifying the need to dedicate special attention to the cases where phenomenon of heterogeneous alternative channels or groups is remarked. In addition, as an example, explicit solution for the model with primary group and 3 heterogeneous alternate channels is obtained. This leads to the comparative support when solving 4 channels system with losses and renewal arrivals. These solutions represent a prospective tool applicable in different serving situations, particularly considering traditional and next generation communications networks.
Reproduction of parasitic mites Varroa destructor in original and new honeybee hosts
Authors: Lin Zheguang , Qin Yao , Page Paul , Wang Shuai , Li Li , Wen Zhengsheng , Hu Fuliang , Neumann Peter , Zheng Huoqing , Dietemann Vincent 
Published: January 2018

AbstractThe ectoparasitic mite, Varroa destructor, shifted host from the eastern honeybee, Apis cerana, to the western honeybee, Apis mellifera. Whereas the original host survives infestations by this parasite, they are lethal to colonies of its new host. Here, we investigated a population of A. cerana naturally infested by the V. destructor Korea haplotype that gave rise to the globally invasive mite lineage. Our aim was to better characterize traits that allow for the survival of the original host to infestations by this particular mite haplotype. A known major trait of resistance is the lack of mite reproduction on worker brood in A. cerana. We show that this trait is neither due to a lack of host attractiveness nor of reproduction initiation by the parasite. However, successful mite reproduction was prevented by abnormal host development. Adult A. cerana workers recognized this state and removed hosts and parasites, which greatly affected the fitness of the parasite. These results confirm and complete previous observations of brood susceptibility to infestation in other honeybee host populations, provide new insights into the coevolution between hosts and parasites in this system, and may contribute to mitigating the large‐scale colony losses of A. mellifera due to V. destructor.
Recolonizing gray wolves increase parasite infection risk in their prey
Authors: Lesniak Ines , Heckmann Ilja , Franz Mathias , Greenwood Alex D. , Heitlinger Emanuel , Hofer Heribert , Krone Oliver 
Published: January 2018

AbstractThe recent recolonization of Central Europe by the European gray wolf (Canis lupus) provides an opportunity to study the dynamics of parasite transmission for cases when a definitive host returns after a phase of local extinction. We investigated whether a newly established wolf population increased the prevalence of those parasites in ungulate intermediate hosts representing wolf prey, whether some parasite species are particularly well adapted to wolves, and the potential basis for such adaptations. We recorded Sarcocystis species richness in wolves and Sarcocystis prevalence in ungulates harvested in study sites with and without permanent wolf presence in Germany using microscopy and DNA metabarcoding. Sarcocystis prevalence in red deer (Cervus elaphus) was significantly higher in wolf areas (79.7%) than in control areas (26.3%) but not in roe deer (Capreolus capreolus) (97.2% vs. 90.4%) or wild boar (Sus scrofa) (82.8% vs. 64.9%). Of 11 Sarcocystis species, Sarcocystis taeniata and Sarcocystis grueneri occurred more often in wolves than expected from the Sarcocystis infection patterns of ungulate prey. Both Sarcocystis species showed a higher increase in prevalence in ungulates in wolf areas than other Sarcocystis species, suggesting that they are particularly well adapted to wolves, and are examples of “wolf specialists”. Sarcocystis species richness in wolves was significantly higher in pups than in adults. “Wolf specialists” persisted during wolf maturation. The results of this study demonstrate that (1) predator–prey interactions influence parasite prevalence, if both predator and prey are part of the parasite life cycle, (2) mesopredators do not necessarily replace the apex predator in parasite transmission dynamics for particular parasites of which the apex predator is the definitive host, even if meso‐ and apex predators were from the same taxonomic family (here: Canidae, e.g., red foxes Vulpes vulpes), and (3) age‐dependent immune maturation contributes to the control of protozoan infection in wolves.
Upscaling biodiversity: estimating the species–area relationship from small samples
Authors: Kunin William E. , Harte John , He Fangliang , Hui Cang , Jobe R. Todd , Ostling Annette , Polce Chiara , Šizling Arnošt , Smith Adam B. , Smith Krister , Smart Simon M. , Storch David , Tjørve Even , Ugland Karl‐Inne , Ulrich Werner , Varma Varun 
Published: January 2018

AbstractThe challenge of biodiversity upscaling, estimating the species richness of a large area from scattered local surveys within it, has attracted increasing interest in recent years, producing a wide range of competing approaches. Such methods, if successful, could have important applications to multi‐scale biodiversity estimation and monitoring. Here we test 19 techniques using a high quality plant data set: the GB Countryside Survey 1999, detailed surveys of a stratified random sample of British landscapes. In addition to the full data set, a set of geographical and statistical subsets was created, allowing each method to be tested on multiple data sets with different characteristics. The predictions of the models were tested against the “true” species–area relationship for British plants, derived from contemporaneously surveyed national atlas data. This represents a far more ambitious test than is usually employed, requiring 5–10 orders of magnitude in upscaling. The methods differed greatly in their performance; while there are 2,326 focal plant taxa recorded in the focal region, up‐scaled species richness estimates ranged from 62 to 11,593. Several models provided reasonably reliable results across the 16 test data sets: the Shen and He and the Ulrich and Ollik models provided the most robust estimates of total species richness, with the former generally providing estimates within 10% of the true value. The methods tested proved less accurate at estimating the shape of the species–area relationship (SAR) as a whole; the best single method was Hui's Occupancy Rank Curve approach, which erred on average by <20%. A hybrid method combining a total species richness estimate (from the Shen and He model) with a downscaling approach (the Šizling model) proved more accurate in predicting the SAR (mean relative error 15.5%) than any of the pure upscaling approaches tested. There remains substantial room for improvement in upscaling methods, but our results suggest that several existing methods have a high potential for practical application to estimating species richness at coarse spatial scales. The methods should greatly facilitate biodiversity estimation in poorly studied taxa and regions, and the monitoring of biodiversity change at multiple spatial scales.