bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Cruciate Ligament Injury at the Time of Anterior Tibial Spine Fracture in Young Patients: An Observational Cohort Study
Authors: Mayo Meredith H. , Mitchell Justin J. , Axibal Derek P. , Chahla Jorge , Palmer Claire , Vidal Armando F. , Rhodes Jason T. 
Published: May 2017

Background:
Anterior tibial spine fractures (ATSF) in the skeletally immature parallel anterior cruciate ligament (ACL) tears in adult patients, yet these injuries are generally regarded as mutually exclusive. Biomechanical analysis suggests that intrinsic ACL damage occurs during ATSF, and long-term clinical studies demonstrate residual anteroposterior knee laxity following ATSF. We aim to describe prevalence, demographics, and characteristics of pediatric patients who sustained ATSF with concomitant ACL injury.

Methods:
We included 129 patients with ATSF over a 16-year period. Age, sex, injury mechanism, ATSF type, magnetic resonance imaging (MRI) evaluation, treatment modality, ACL injury, and concomitant meniscal/chondral injuries were analyzed. Concurrent ACL injury was confirmed either from MRI or intraoperatively.

Results:
Nineteen percent (n=25) of ATSF patients had concomitant ACL injury, with ACL injury significantly more likely in type II or type III ATSF compared with type I ATSF (P=0.03). Patients with combined ATSF/ACL injury were significantly older (P=0.02) and more likely to be male (P=0.01). Mechanism of ATSF injury was not associated with ACL injury (P=0.83). Preoperative MRI had low sensitivity (0.09) for recognizing ACL injury at the time of ATSF relative to intraoperative assessment. Half of ATSF/ACL-injured patients had additional meniscal or chondral injury, with meniscal repair or debridement required in 37.5% of the type II ATSF/ACL injury.

Conclusions:
There are demographic characteristics, such as age (older) and sex (male), associated with a higher risk of concomitant ACL injury at the time of ATSF. Type II and type III ATSF patterns had a higher prevalence of ACL injury. MRI failed to correctly identify ACL injury at the time of ATSF. Concomitant ACL injury at the time of ATSF is highly prevalent in the skeletally immature, occurring in 19.4% of patients with ATSF.

Level of Evidence:
Level IV—case series.
Ankle Syndesmotic Injuries: A Systematic Review
Authors: Levy David M. , Reid Kristoff , Gross Christopher E. 
Published: May 2017

Background:
The syndesmosis is critical in maintaining the structural integrity of the distal tibiofibular joint, and perhaps as much as 10% of all ankle fractures are accompanied by a syndesmotic injury. The purpose of this study is to review all relevant literatures on the treatment of syndesmotic ankle fractures.

Materials and Methods:
A systematic review was conducted using PubMed, Medline, EMBASE, and the Cochrane Central Register of Controlled Trials. The keyword selection was designed to capture all levels I to IV evidence English-language studies that reported clinical and/or radiographic outcomes. All case reports and studies with a minimum follow-up of <1 year were excluded. In total, 18 studies with 951 patients and ankles were selected for inclusion. P-value of 0.05 was set as statistically significant.

Results:
The studies ranged from January 1974 through August 2014, and the average age was 43.7±5.6 years with 57.4% of patients being male. All studies evaluated the efficacy of open reduction internal fixation. Metallic screws were the primary mode of fixation in 16 studies, whereas none of the studies evaluated the efficacy of nonoperative or endoscopic treatment. Totally, 148 screws were reported broken at the time of final follow-up, and syndesmotic screws were removed 8.5±3.7 weeks after surgery. The average time to clinical follow-up was 43.0±56.7 months. Postoperative visual analog scale pain scores (maximum 10) were 2.3±1.3, American Orthopaedic Foot and Ankle Society scores were 88.7±4.1, and Olerud-Molander scores were 80.1±5.3. Only 4 studies reported 14 complications (2.8±3.1), whereas 5 studies reported 8 revision operations (1.0±1.3).

Discussion:
This systematic review primarily confirms that syndesmotic injuries are successfully treated with open reduction internal fixation. Syndesmotic screws are commonly removed within first 3 months after surgery.

Level of Evidence:
Level IV—systematic review of levels I to IV studies.
Family History of Migraine Associated With Posttraumatic Migraine Symptoms Following Sport-Related Concussion
Authors: Sufrinko Alicia , McAllister-Deitrick Jamie , Elbin RJ , Collins Michael W. , Kontos Anthony P. 
Published: May 2017

Objective:
To determine whether family history of migraine increased the likelihood of posttraumatic migraine (PTM) symptom presentation in adolescents following concussion, and examine the influence of family history of migraine and PTM on postinjury outcomes.

Setting:
Outpatient concussion clinic.

Participants:
A total of 153 patients with concussion (103 males and 50 females) aged 15.72 ± 1.48 years (range 12–18 years).

Design:
Cross-sectional, observational study of patients presenting for initial evaluation 4.72 ± 3.05 days (range 1–14) postinjury.

Main Measures:
Computerized neurocognitive testing, symptom report, and vestibular/oculomotor screening.

Results:
Patients with a family history of migraine were 2.6 times (odds ratio = 2.60, confidence interval = 1.35–5.02, P = .003) more likely to present with PTM compared with patients without a family history. Results of multivariate analyses of covariance, controlling for concussion history, revealed significant main effects for PTM on (1) Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT)/Post-Concussion Symptom Scale (PCSS) (F = 15.43, P <.001) and (2) Vestibular/Ocular Motor Screening (VOMS) (F = 8.52, P < .001). There was no main effect for family history of migraine on ImPACT/PCSS (P = .22) and VOMS (P = .83) or interaction between family history of migraine and PTM on ImPACT/PCSS (P = .84) and VOMS (P = .52).

Conclusion:
Family history of migraine is associated with PTM symptoms following sport-related concussion, suggesting a genetic predisposition for migraine may serve as a catalyst or trigger for onset of PTM. However, only presence of PTM, rather than family history of migraine, was related to worse neurocognitive and vestibular/oculomotor outcomes.
Investigating the Connection Between Traumatic Brain Injury and Posttraumatic Stress Symptoms in Adolescents
Authors: Rhine Tara , Cassedy Amy , Yeates Keith Owen , Taylor Hudson Gerry , Kirkwood Michael W. , Wade Shari L. 
Published: May 2017

Objective:
To identify potentially modifiable individual and social-environmental correlates of posttraumatic stress symptoms (PTSS) among adolescents hospitalized for traumatic brain injury (TBI).

Setting:
Four pediatric hospitals and 1 general hospital in the United States.

Participants:
Children ages 11 to 18 years, hospitalized for moderate-severe TBI within the past 18 months.

Design:
Retrospective cross-sectional analysis.

Main Measures:
The University of California at Los Angeles (UCLA) Post-traumatic Stress Disorder (PTSD) Reaction Index and the Youth Self-Report (YSR) PTSD subscale.

Results:
Of 147 adolescents enrolled, 65 (44%) had severe TBI, with an average time since injury of 5.8 ± 4 months. Of the 104 who completed the UCLA-PTSD Reaction Index, 22 (21%) reported PTSS and 9 (8%) met clinical criteria for PTSD. Of the 143 who completed the YSR-PTSD subscale, 23 (16%) reported PTSS and 6 (4%) met clinical criteria for PTSD. In multivariable analyses, having a negative approach to problem solving and depressive symptoms were both associated (P < .001) with higher levels of PTSS based on the UCLA-PTSD Reaction Index (β = 0.41 and β = 0.33, respectively) and the YSR-PTSD subscale (β = 0.33 and β = 0.40, respectively).

Conclusion:
Targeting negative aspects of problem solving in youths after brain injury may mitigate PTSS.
A longitudinal study of the influence of comorbidities and lifestyle factors on low back pain in older men
Authors: Parreira Patricia C.S. , Maher Chris G. , Ferreira Manuela L. , Machado Gustavo C. , Blyth Fiona M. , Naganathan Vasi , Waite Louise M. , Seibel Markus J. , Handelsman David , Cumming Robert G. 
Published: May 2017

Abstract
Older adults are largely under-represented in low back pain (LBP) research. In light of the ageing population, it is crucial to understand the influence of comorbidities and lifestyle factors on the risk and prognosis of LBP in older adults. The aims of this study were to describe the course of LBP in older men; to investigate whether comorbidities/lifestyle factors can predict the course of LBP in older men; to assess if comorbidities/lifestyle factors increase the risk of developing LBP in older men. The study sample comprised 1685 older men living in suburban Sydney, Australia. Low back pain, sociodemographic measures, lifestyle factors, and comorbidities were assessed. Of the 1012 men with LBP at baseline, 58% still reported having pain at the 24-month follow-up. Of those without pain at baseline (n = 673), 28% reported pain at follow-up. The odds of persistent pain at 24 months increased with each additional alcoholic drink/wk (odds ratio [OR] = 1.10, 95% confidence interval [CI]: 1.01-1.22; P = 0.03) and each additional unit of body mass index (OR = 1.28, 95% CI: 1.04-1.60; P = 0.02), but reduced for men who speak English at home (OR = 0.58, 95% CI: 0.35-0.96; P = 0.03). In older men, free of LBP at baseline (n = 673), for every additional comorbidity there was an increased risk of developing LBP (OR = 1.17, 95% CI: 1.00-1.37; P = 0.05). These results demonstrate the influence of lifestyle factors and comorbidities on LBP in older men and suggest that the consideration of these issues in management may improve outcomes.
“Modulation of apoptosis controls inhibitory interneuron number in the cortex”
Authors: Denaxa Myrto , Neves Guilherme , Rabinowitz Adam , Kemlo Sarah , Liodis Petros , Burrone Juan , Pachnis Vassilis 
Published: May 2017

AbstractCortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how the correct number of cortical interneurons (CIs) is established in the mammalian forebrain. CIs are generated in excess from basal forebrain progenitors and their final numbers are adjusted via an intrinsically determined program of apoptosis that takes place during an early postnatal window. Here, we provide evidence that the extent of CI apoptosis during this critical period is plastic, cell type specific and can be reduced in a cell autonomous manner by acute increases in neuronal activity. We propose that the physiological state of the emerging neural network controls the activity levels of local CIs to modulate their numbers in a homeostatic manner.
The human visual cortex response to melanopsin-directed stimulation is accompanied by a distinct perceptual experience
Authors: Spitschan Manuel , Bock Andrew S. , Ryan Jack , Frazzetta Giulia , Brainard David H. , Aguirre Geoffrey K. 
Published: May 2017

AbstractThe photopigment melanopsin supports reflexive visual functions in people, such as pupil constriction and circadian photoentrainment. What contribution melanopsin makes to conscious visual perception is less studied. We devised a stimulus that targeted melanopsin separately from the cones using pulsed (3 s) spectral modulations around a photopic background. Pupil-lometry confirmed that the melanopsin stimulus drives a retinal mechanism distinct from luminance. In each of four subjects, a functional MRI response in area V1 was found. This response scaled with melanopic contrast and was not easily explained by imprecision in the silencing of the cones. Twenty additional subjects then observed melanopsin pulses and provided a structured rating of the perceptual experience. Melanopsin stimulation was described as an unpleasant, blurry, minimal brightening that quickly faded. We conclude that isolated stimulation of melanopsin is likely associated with a response within the cortical visual pathway and with an evoked conscious percept.
Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C
Authors: Chinthalapudi Krishna , Heissler Sarah M. , Preller Matthias , Sellers James R. , Manstein Dietmar J. 
Published: May 2017

AbstractThe cyclical interaction of myosin with F-actin and nucleotides is the basis for contractility of the actin cytoskeleton. Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosins-2 isoforms. Here, we present a 2.25 Å crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins characterized. In combination with integrated mutagenesis, ensemble-solution kinetics, and molecular dynamics simulations approaches, this study reveals an allosteric communication pathway that connects the distal end of the motor domain with the active site. Genetic disruption of this pathways reduces nucleotide binding and release kinetics up to 85-fold and abolishes nonmuscle myosin-2 specific kinetic signatures. These results provide insights into structural changes in the myosin motor domain that are triggered upon F-actin binding and contribute critically to the mechanochemical behavior of stress fibers, actin arcs, and cortical actin-based structures.
Revisiting theAncylostoma caninumsecretome provides new information on hookworm-host interactions
Authors: Morante Taylor , Shepherd Catherine , Constantinoiu Constantin , Loukas Alex , Sotillo Javier 
Published: May 2017

ABSTRACTHookworm infection is a major tropical parasitic disease affecting almost 500 million people worldwide. These soil-transmitted helminths can survive for many years in the intestine of the host, where they feed on blood, causing iron deficiency anaemia and other complications. To avoid the host’s immune response the parasite releases excretory/secretory products (ESPs), a complex mixture of glycans, lipids and proteins that represent the major host-parasite interface. Using a combination of separation techniques such as SDS-PAGE and OFFGEL electrophoresis, in combination with state-of-the-art mass spectrometry we have reanalysed the dog hookworm,Ancylostoma caninum, ESPs (AcES). We identified 315 proteins present in theAcES, compared with just 105 identified in previous studies. The most highly represented family of proteins is the SCP/TAPs (90 of the 315 proteins), and the most abundant constituents ofAcES are homologues of the tissue inhibitors of metalloproteases (TIMP) family. We identified putative vaccine candidates and proteins that could have immunomodulatory effects for treating inflammatory diseases. This study provides novel information about the proteins involved in host-hookworm interactions, and constitutes a comprehensive dataset for the development of vaccines and the discovery of new immunoregulatory biologics.
Modeling science trustworthiness under publish or perish pressure
Authors: Grimes David Robert , Bauch Chris T. , Ioannidis John P.A. 
Published: May 2017

AbstractThe scientific endeavor pivots on the accurate reporting of experimental and theoretical findings, and consequently scientific publication is immensely important. As the number of active scientists continues to increase, there is concern that rewarding scientists chiefly on publication creates a perverse incentive where careless and fraudulent research can thrive. This is compounded by the predisposition of top-tier journals towards novel or positive findings rather than negative results or investigations that merely confirm a null hypothesis, despite their intrinsic value, potentially compounding a reproducibility crisis in several fields. This is a serious problem for both science and public trust in scientific findings. To date, there has been comparatively little mathematical modeling on the factors that influence science trustworthiness, despite the importance of quantifying the problem. In this work, we present a simple phenomenological model with cohorts of diligent, careless and unethical scientists with funding allocated based on published outputs. The results of this analysis suggest that trustworthiness of published science in a given field is strongly influenced by the false positive rate and the pressures from journals for positive results, and that decreasing available funding has negative consequences for the resulting trustworthiness. We also examine strategies to combat propagation of irreproducible science, including increasing fraud detection and awarding diligence, discussing the implications of these findings.
Cryo-EM of aMarseilleviridaevirus particle reveals a large internal microassembly
Authors: Okamoto Kenta , Miyazaki Naoyuki , Reddy Hemanth K.N. , Hantke Max F. , Maia Filipe R.N.C. , Larsson Daniel S. D. , Abergel Chantal , Claverie Jean-Michel , Hajdu Janos , Murata Kazuyoshi , Svenda Martin 
Published: May 2017

AbstractNucleocytoplasmic large DNA viruses (NCLDVs) blur the line between viruses and cells. Melbournevirus (MelV, fam.Marseilleviridae) belongs to a new family of NCLDVs. Here we present an electron cryo-microscopy structure of the MelV particle, with the largest known triangulation number (T=309) for a virus. The 230-nm particle is constructed by 3080 pseudo-hexagonal capsomers and encloses a membrane bilayer. Its most distinct feature is a large dense body (LDB) consistently found in all particles. Electron cryo-tomography of 147 particles showed that the LDB is located preferentially in proximity to the bilayer. The LDB is 30 nm in size and its density matches that of a genome/protein complex. More than 58 proteins are associated with the purified particle, including histone-like proteins, putative membrane proteins and capsid proteins. The observed intricate structural organization reinforces the genetic complexity of MelV, setting it apart from other viruses, and suggests an evolutionary link with cellular organisms.
Globalization and bank efficiency nexus: empirical evidence from the Malaysian banking sector
Authors: Sufian Fadzlan , Kamarudin Fakarudin , Md. Nassir Annuar 
Published: May 2017

Purpose
The purpose of this paper is to provide a new empirical evidence on the impact of economic globalization on the efficiency of the banking sector. The paper also investigates to what extent the internal (i.e. bank specific characteristics) and external (i.e. macroeconomic conditions) factors influence the efficiency of banks while controlling for the impact of the different dimensions of globalization.

Design/methodology/approach
The analysis is confined into two stages. In the first stage, the authors employ the bias-corrected data envelopment analysis method to compute the efficiency of individual banks during the period 1999-2012. The authors then use bootstrap regressions to examine the impact of economic globalization on bank efficiency, while controlling for the potential impacts of contextual variables.

Findings
The empirical findings indicate that the impacts of personal contacts, information flows, and cultural proximity seem to work in favor of Malaysian banks’ efficiency. A plausible reason could be due to the fact that capital account liberalization is usually accompanied by liberalization of the financial services sector, resulting in a greater competition and subsequently eroding monopolistic profits. The empirical findings also bring forth the importance of and political globalization in determining the efficiency of banks operating in the Malaysian banking sector.

Originality/value
The present study aims to provide for the first time empirical evidence on the performance of the banking sector and to establish new empirical evidence on the impact of globalization. The empirical evidence on the impact of globalization on the banking sector is completely missing from the literature.
Capability assessment of Army spare parts replenishment system
Authors: Sharma Pankaj , Kulkarni Makarand S. , Parlikad Ajith 
Published: May 2017

Purpose
The purpose of this paper is to identify the strengths and weaknesses of the current spare parts replenishment system of the Army. This exercise is being done with an aim to assess the capability of the current system to implement a time separated lean-agile system of spare parts replenishment.

Design/methodology/approach
The paper is based on a survey conducted on people in managerial ranks, working in the field of military logistics. The survey is thereafter summarised to ascertain the current status of spare parts replenishment system in the Army. The findings of the survey are elaborated at the end of the paper.

Findings
The strengths of the current spare parts replenishment system are highlighted. This is followed with the weaknesses of the system in implementing a dynamic lean-agile replenishment system.

Originality/value
The paper is aimed at assessing the capability of the current spare parts replenishment system and its ability to adapt to a novel replenishment system that is lean in peacetime to save money and agile during war to increase reliability of equipment achieved by a certainty of supply. The survey conducted on the persons actually involved in this logistics reveals areas that need emphasis in order to achieve such a time separated lean-agile replenishment system.
Relationships among ERP, supply chain orientation and operational performance
Authors: Acar Mehmet Fatih , Zaim Selim , Isik Mine , Calisir Fethi 
Published: May 2017

Purpose
The purpose of this paper is to investigate the interactions among enterprise resource planning (ERP) practices, supply chain orientation (SCO), and operational performance (OPER) by forming a macro perspective based on a scientific foundation powered by a resource-based view.

Design/methodology/approach
Exploratory and confirmatory factor analyses were used to verify the underlying dimensions of SCO and ERP practices. The covariance-based structural equation modeling was employed to test the direct and indirect effects of SCO and ERP practices constructs on OPER.

Findings
Results revealed that SCO has significant and positive effects on OPER, whereas ERP practices do not. Moreover, the indirect effect of ERP practices with the mediating effects of SCO is stronger than their direct effects. In addition, the origin of the ERP practices is found to be an important critical success factor.

Originality/value
Although much research has investigated the direct effect of ERP practices on performance, this study points out the importance of SCO in observing the stronger impacts of ERP practices.