bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective observational study of maternal oxygenation during remifentanil patient‐controlled analgesia use in labour
Authors: Messmer A. A. , Potts J. M. , Orlikowski C. E. 
Published: November 2015

SummaryNumerous studies of remifentanil patient‐controlled analgesia during labour have shown high levels of maternal satisfaction, but concerns remain, especially over the side‐effects of sedation and respiratory depression. We conducted a prospective observational study of maternal oxygen desaturation during remifentanil patient‐controlled analgesia. Pulse oximetry values were recorded every eight s and later downloaded for analysis. A desaturation episode was defined as oxygen saturation < 90%. We collected 148 h of data in 61 women, during which we observed 176 desaturation episodes. These episodes occurred in 43 (70%) women. The median (IQR [range]) of the lowest saturation during each episode was 87 (85–89 [68–89])% with duration 16 (8–24 [8–104]) s. Supplementary oxygen reduced the time per hour spent with saturation < 90%, but not the depth or duration of individual episodes. Desaturation episodes were twice as common during the second stage of labour as compared with the first stage. Prior opioid administration, bolus size and use of nitrous oxide during patient‐controlled analgesia use were not found to influence frequency, depth or duration of desaturation episodes. Although these findings suggest desaturation occurs more frequently during remifentanil patient‐controlled analgesia than previously reported, the results are comparable with earlier oximetry studies of women who received nitrous oxide and pethidine during labour.
Refusing to be Toured: Work, Tourism, and the Productivity of “Life” in the Colombian Amazon
Authors: Craven Caitlin E. 
Published: November 2015

AbstractStarting from the contention that exercising a “right to tour” is predicated on the work of producing tourability, I examine how tourability itself is a contested process involving relations of land and labour. Examining the current “resource boom” of ecotourism in the Colombian Amazon, I use an analysis of work and capital accumulation to unravel a seemingly small act of refusal by the community of Nazaret that has barred tourists’ entry to their land. I argue that this act of refusal opens up space for critically examining the relationships of land and labour, especially through the production of “life”, in the accumulation of tourable places in contemporary global capitalism. Engaging literature on both tourism studies and land politics in the Amazon region, I contribute to the scholarship on tourism and work while examining how Indigenous landscapes are being made productive towards the ends of capitalism.
A record of the Messinian salinity crisis in the eastern Ionian tectonically active domain (Greece, eastern Mediterranean)
Authors: Karakitsios Vasileios , Roveri Marco , Lugli Stefano , Manzi Vinicio , Gennari Rocco , Antonarakou Assimina , Triantaphyllou Maria , Agiadi Konstantina , Kontakiotis George , Kafousia Nefeli , de Rafelis Marc 
Published: November 2015

AbstractThis integrated study (field observations, micropalaeontology, magnetostratigraphy, geochemistry, borehole data and seismic profiles) of the Messinian–Zanclean deposits on Zakynthos Island (Ionian Sea) focuses on the sedimentary succession recording the pre‐evaporitic phase of the Messinian salinity crisis (MSC) through the re‐establishment of the marine conditions in a transitional area between the eastern and the western Mediterranean. Two intervals are distinguished through the palaeoenvironmental reconstruction of the pre‐evaporitic Messinian in Kalamaki: (a) 6.45–6.122 Ma and (b) 6.122–5.97 Ma. Both the planktonic foraminifer and the fish assemblages indicate a cooling phase punctuated by hypersalinity episodes at around 6.05 Ma. Two evaporite units are recognized and associated with the tectonic evolution of the Kalamaki–Argassi area. The Primary Lower Gypsum (PLG) unit was deposited during the firstMSCstage (5.971–5.60 Ma) in late‐Messinian marginal basins within the pre‐Apulian foreland basin and in the wedge‐top (<300 m) developed over the Ionian zone. During the secondMSCstage (5.60–5.55 Ma), thePLGevaporites were deeply eroded in the forebulge–backbulge and the wedge‐top areas, and supplied the foreland basin's depocentre with gypsum turbidites assigned to the Resedimented Lower Gypsum (RLG) unit. In this study, we propose a simple model for the Neogene–Pliocene continental foreland‐directed migration of the Hellenide thrusting, which explains the palaeogeography of the Zakynthos basin. The diapiric movements of the Ionian Triassic evaporites regulated the configuration and the overall subsidence of the foreland basin and, therefore, theMSCexpression in this area.
Novel therapeutic compound tuftsin–phosphorylcholine attenuates collagen-induced arthritis
Authors: Bashi T , Shovman O , Fridkin M , Volkov A , Barshack I , Blank M , Shoenfeld Y 
Published: November 2015

Summary
Treatment with helminthes and helminthes ova improved the clinical symptoms of several autoimmune diseases in patients and in animal models. Phosphorylcholine (PC) proved to be the immunomodulatory molecule. We aimed to decipher the tolerogenic potential of tuftsin–PC (TPC), a novel helminth-based compound in collagen-induced arthritis (CIA) a mouse model of rheumatoid arthritis (RA). CIA DBA/1 mice were treated with TPC subcutaneously (5 µg/0.1 ml) or orally (250 µg/0.1 ml), starting prior to disease induction. The control groups were treated with PBS. Collagen antibodies were tested by enzyme-linked immunosorbent assay (ELISA), cytokine protein levels by ELISA kits and regulatory T (Treg) and regulatory B (Breg) cell phenotypes by fluorescence-activated cell sorter (FACS). TPC-treated mice had a significantly lower arthritis score of 1.5 in comparison with control mice 11.8 (P &lt; 0.0001) in both subcutaneous and orally treated groups at day 31. Moreover, histology analysis demonstrated highly inflamed joints in control mice, whereas TPC-treated mice maintained normal joint structure. Furthermore, TPC decreased the titres of circulating collagen II antibodies in mice sera (P &lt; 0.0001), enhanced expression of IL-10 (P &lt; 0.0001) and inhibited production of tumour necrosis factor (TNF)-α, interleukin (IL)−17 and IL-1β (P &lt; 0.0001). TPC significantly expanded the CD4+CD25+ forkhead box protein 3 (FoxP3+) Treg cells and CD19+IL-10+CD5highCD1dhighT cell immunoglobulin mucin-1 (TIM-1+) Breg cell phenotypes (P &lt; 0.0001) in treated mice. Our data indicate that treatment with TPC attenuates CIA in mice demonstrated by low arthritic score and normal joints histology. TPC treatment reduced proinflammatory cytokines and increased anti-inflammatory cytokine expression, as well as expansion of Treg and Breg cells. Our results may lead to a new approach for a natural therapy for early rheumatoid arthritis onset.
Role of the Lakes in Groundwater Recharge and Discharge in the Young Glacial Area, Northern Poland
Authors: Jaworska‐Szulc Beata 
Published: November 2015

AbstractThe aim of this research was to delineate characteristic hydrogeological lake types in the Young Glacial Area (YGA). The YGA is in the central and east part of the Kashubian Lake District (KLD) in Northern Poland, an area covered by deposits of Quaternary glaciation. All the bigger lakes were investigated in the area of about 1500 km2 (39 lakes). The role of lakes in groundwater recharge and discharge was determined from total dissolved solids (TDS) in lake waters and also from groundwater flow simulation. The general trend was that gaining lakes, as determined by flow modeling, had higher values of TDS than losing lakes. In addition to typical gaining lakes (with TDS > 250 mg/l), there were losing lakes perched on glacial till deposits with very low TDS (<100 mg/l). Two groups of losing lakes were delineated: ones with very low TDS and another group with slightly higher TDS (due to local contact with groundwater). Flow‐through lakes with TDS of 170–200 mg/l were also delineated.
A Review of Cardiovascular Autonomic Control in Cluster Headache
Authors: Barloese Mads C.J. 
Published: November 2015

ObjectiveThis review aims to evaluate existing literature concerning cardiovascular autonomic function and CH. Suggestions about future research are offered and known difficulties in investigating the autonomic nervous system in cluster headache are discussed.BackgroundLittle is known of the pathophysiological mechanisms behind cluster headache. Cranial autonomic features are an inherent and diagnostic feature; however, a number of studies and clinical observations support the involvement of systemic autonomic control in its pathophysiology. Further, cluster headache attacks are apparently more easily triggered during periods of parasympathetic dominance. A better understanding of this interaction may provide insight into central autonomic regulation and its role in cluster headache.MethodsA PubMed search was performed in April 2015 using the search terms “cluster headache,” “cardiovascular,” “autonomic nervous system,” and “cardiac.” References of identified articles were also searched for relevant articles. Studies were included if they contained data on cardiovascular or autonomic responses to autonomic tests, induced or spontaneous attacks.ResultsIn total, 22 studies investigating cardiac autonomic control in cluster headache were identified. Three overall categories of investigations exist: (1) Those studying changes in heart rate, blood pressure, and electrocardiographic changes; (2) those employing various clinical autonomic tests; and finally (3) those using spectral and nonlinear analysis of heart rate variability. Although not completely congruent, overall, results suggest ictal hyperactivation of the parasympathetic branch and a sympathetic deficit. Subclinical autonomic dysregulation is also present in the pain‐free state.ConclusionCardiac autonomic control is subclinically affected in cluster headache. The changes could be attributed to the suggested central dysregulation present in this disorder.
Rapid societal change as a proxy for regional environmental forcing: Evidence and explanations for Pacific island societies in the 14–15th centuries
Authors: Goff James , Nunn Patrick D. 
Published: November 2015

AbstractGiven the unquestioned impacts of recent/future environmental changes on human societies, it is reasonable to posit that past societal responses could be used as proxies of contemporaneous environmental forcing and might help identify the drivers of these, particularly where independent evidence of the effects of these events is inadequate. Such areas include Pacific oceanic islands for most of which there is evidence of a societal perturbation in the 14th and 15th centuries that saw the outbreak of region‐wide conflict, abandonment of coastal settlements and the abrupt end of long‐distance cross‐ocean voyaging networks. The contemporaneity of these effects across a vast region requires a driver that is external to particular island groups with the only possibility that of oceanic origin, most likely large waves (tsunamis or storm surges) or rapid sea‐level change. The explanation is less important than the principle that societal changes can be used as proxies for environmental activity.
Multicriteria decision‐making approach based on gray linguistic weighted Bonferroni mean operator
Authors: Tian Zhang‐Peng , Wang Jing , Wang Jian‐Qiang , Chen Xiao‐Hong 
Published: November 2015

AbstractThe main purpose of this paper is to provide a multicriteria decision‐making (MCDM) approach that applies the gray linguistic Bonferroni mean (BM) operator to address the situations where the criterion values take the form of gray linguistic numbers (GLNs) and the criterion weights are known. First, the related operations and comparison method for GLNs are provided. Subsequently, a BM operator and weighted BM operator of GLNs are developed. Then, based on the gray linguistic weighted BM operator, an MCDM approach is proposed. Finally, an illustrative example is given and a comparison analysis is conducted between the proposed approach and other existing methods to demonstrate the effectiveness and feasibility of the developed approach.
Pricing and advertising the relief goods under various information sharing scenarios
Authors: Zhang Ting , Zhu Xiaowei , Zhou Chuiri , Liu Mengqi 
Published: November 2015

AbstractWe study the strategic implications of the advertising and pricing problem with market disruptions where a manufacturer sells relief goods to the end customers through a retailer in a natural disaster. We focus on the impact of forecast and value of keeping information private on advertising and pricing decisions. Three information cases, including noninformation sharing (N), information sharing (I), and retailer forecasting (R), are studied. For each case, we derive the optimal national advertising effort and wholesale price for the manufacturer, and the optimal local advertising effort and retail price for the retailer. We then compare the three cases and derive conditions under which the two parties should share information with each other. Results of extensive numerical experimentation are also presented.
An approach to multiplicative linguistic group decision making based on possibility degrees
Authors: Xia Meimei , Xu Zeshui 
Published: November 2015

AbstractIn order to compare two uncertain multiplicative linguistic variables, a possibility degree formula has been developed and its properties are also studied. Then a possibility degree matrix (also considered as a reciprocal preference relation) is constructed to compare a collection of uncertain multiplicative linguistic variables. Two models are further provided to derive the priority vector from the possibility degree matrix based on the additive consistency and multiplicative consistency. Especially, if the parameters are assigned specific values, then the models reduce to the existing ones. A group decision making method has been developed to deal with the situations where the preferences on alternatives are expressed by uncertain multiplicative linguistic variables. In this method, the possibility degree matrix is first constructed, from which the priority of alternatives is obtained using the developed models. At the end, an example is given to illustrate the proposed method.
The inventory routing problem: the value of integration
Authors: Archetti Claudia , Speranza M. Grazia 
Published: November 2015

AbstractWe consider an inventory routing problem in which a supplier delivers goods to customers over a given planning period. Before the advent of the supply chain management concept, customers usually applied a policy for the inventory management. The supplier then, on the basis of the distribution schedule determined by the customers, organized the distribution routes. In an integrated approach, the supplier has access to the inventory levels at the customers and knowledge of their demand process. On the basis of this information the supplier organizes a complete distribution plan, determining the days of visit, quantities to deliver, and distribution routes. This integrated policy is called vendor‐managed inventory policy. We solve the optimization problems arising in the traditional and integrated management, and analyze the two approaches, comparing the costs and characteristics of the different solutions.
Sociological Approaches to the European Union in Times of Turmoil
Authors: Saurugger Sabine 
Published: November 2015

AbstractThis contribution aims at questioning the explanatory capacity of sociological approaches to European integration in times of crisis. Its main argument is that in times of turmoil – perceived or real – analysis of actors’ strategies and cognitive frames is crucial for understanding the emergence of solutions proposed to remedy the problem. Starting from a sociological definition of crisis, the article illustrates through empirical examples how the cognitive frames in which actors evolve determine their analysis of problems as well as solutions. Sociological approaches to public policy, which reject the basic assumption of actors behaving solely according to a presumed material cost–benefit analysis, help us to better grasp the complexity of decision‐making. The main reason for this is that they allow for linking the domestic and European levels when analysing cognitive and decision‐making processes, instead of concentrating on either European citizens or European elites separately.
Regulation Theory and the Political Economy of the European Union
Authors: Bieling Hans‐Jürgen , Jäger Johannes , Ryner Magnus 
Published: November 2015

AbstractEuropean integration theory considers to what extent the EU can realize a telos where American pluralism is the template. Not without merits, but considering the financial and eurozone crises fatally, such perspectives elide power relations and attendant contradictions and irrationalities that are constitutive of transatlantic integration itself. Regulation theory, which synthesizes the reformist ethos of Europe's postwar statist tradition and Marxism, and which has produced a considerable body of analysis of the EU published at the margins of EU scholarship, offers a compelling alternative that potentially overcomes these shortcomings. This article critically assesses how regulation theory has interpreted the single market, financial liberalization and EMU as a suppression of alternatives to neoliberal post‐Fordism, or finance‐led accumulation, in Europe. It argues that understanding the EU's current conjuncture of eurozone crisis management requires a neo‐Gramscian extension of regulation theory, stressing transnational patterns of capitalist accumulation and power relations.
Parenting behavior at 2 years predicts school‐age performance at 7 years in very preterm children
Authors: Treyvaud Karli , Doyle Lex W. , Lee Katherine J. , Ure Alexandra , Inder Terrie E. , Hunt Rod W. , Anderson Peter J. 
Published: November 2015

BackgroundParenting influences child development, but it is unclear whether early parenting behavior can influence school‐age outcomes in very preterm (VPT) children, and/or if certain groups of VPT children may be more affected by early parenting behavior. These research questions were examined.MethodsParticipants were 147 children born <30 weeks’ gestation or birth weight <1250 g and their primary caregiver. At term corrected age (CA), magnetic resonance imaging (MRI) was used to determine presence and severity of brain abnormality and medical data collected. High medical risk was defined as the presence of at least one of sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, moderate to severe white matter abnormality on MRI, or postnatal corticosteroids. At 2 years CA, parent–child interaction was assessed, and at 7 years CA, general intelligence (IQ), language, executive function, academic skills, and social‐emotional functioning were assessed.ResultsHigher levels of parent–child synchrony, and parent facilitation, sensitivity and positive affect at 2 years were associated with better child outcomes at 7 years, while higher levels of intrusiveness and negative affect were associated with poorer outcomes. Many of these relationships remained after controlling for early child cognitive development. Interactions between child medical risk (higher/lower) and parenting were limited to child reading, math, and executive functioning outcomes, with stronger relationships for lower medical risk children.ConclusionsThe contribution of early parenting to VPT children's school‐age performance is significant, with stronger effects for lower medical risk children in some outcomes. These findings support the premise that parenting strategies should be included in the NICU and early interventions programs for VPT infants.
Attenuation of cerebral ischemic injury in interferon regulatory factor 3‐deficient rat
Authors: Li Lei , Qin Juan‐Juan , Guo Sen , Zhang Peng , Gong Jun , Zhang Xiao‐Jing , Zheng Ankang , Xia Hao , Li Hongliang 
Published: November 2015

AbstractInterferon regulatory factor 3 (IRF3) is a transcription factor that plays a central role in the innate immune response, apoptosis, and oncogenesis. Previous studies have shown that endogenous IRF3 does not affect stroke in mice; however, paradoxically, elevated IRF3 expression was observed in the rat brains following cerebral ischemia/reperfusion (I/R) injury, indicating that IRF3 may have different functions during stroke in rats than in mice. A clear and comprehensive study of the effect of IRF3 on stroke in rats has been hampered by the lack of an IRF3‐knockout rat strain. In this study, a novel IRF3 knockout rat strain and a transgenic rat strain with neuronal‐specific IRF3 over‐expression (IRF3‐TG) were created. Subsequently, the generated IRF3‐knockout rats, the neuronal‐specific IRF3 over‐expressing rats and their corresponding controls were subjected to transient middle cerebral artery occlusion and followed by reperfusion, to investigate the exact role of IRF3 in cerebral I/R in rats. In contrast to the results in mice, IRF3 deficiency in rats provided significant protection against cerebral I/R injury and inhibited neuronal apoptosis, inflammation, and oxidative stress after cerebral I/R injury; the opposite patterns were observed in neuronal‐specific IRF3 over‐expressing rats. Taken together, these data demonstrate that IRF3 plays a negative regulatory role in cerebral I/R in rats, and IRF3 may be an attractive therapeutic target for preventing stroke.
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In the present study, we discovered that the transcription factor IRF3, which plays a central role in the innate immune response, apoptosis, and oncogenesis, could exacerbate cerebral ischemia/reperfusion (I/R) injury via activating caspase‐dependent neuronal apoptosis, inducing inflammation and oxidative stress. These findings suggest that IRF3 may be an attractive therapeutic target for the prevention of stroke.
Sorting out release, uptake and processing of alpha‐synuclein during prion‐like spread of pathology
Authors: Tyson Trevor , Steiner Jennifer A. , Brundin Patrik 
Published: November 2015

AbstractParkinson's disease is a progressive neurological disorder that is characterized by the formation of intracellular protein inclusion bodies composed primarily of a misfolded and aggregated form of the protein α‐synuclein. There is growing evidence that supports the prion‐like hypothesis of α‐synuclein progression. This hypothesis postulates that α‐synuclein is a prion‐like pathological agent and is responsible for the progression of Parkinson pathology in the brain. Potential misfolding or aggregation of α‐synuclein that might occur in the peripheral nervous system as a result of some insult, environmental or genetic (or more likely a combination of both) that might spread into the midbrain, eventually causing degeneration of the neurons in the substantia nigra. As the disease progresses further, it is likely that α‐synuclein pathology continues to spread throughout the brain, including the cortex, leading to deterioration of cognition and higher brain functions. While it is unknown why α‐synuclein initially misfolds and aggregates, a great deal has been learned about how the cell handles aberrant α‐synuclein assemblies. In this review, we focus on these mechanisms and discuss them in an attempt to define the role that they might play in the propagation of misfolded α‐synuclein from cell‐to‐cell.
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The prion‐like hypothesis of α‐synuclein pathology suggests a method for the transmission of misfolded α‐synuclein from one neuron to another. This hypothesis postulates that misfolded α‐synuclein becomes aggregation prone and when released and taken up by neighboring cells, seeds further misfolding and aggregation. In this review we examine the cellular mechanisms that are involved in the processing of α‐synuclein and how these may contribute to the prion‐like propagation of α‐synuclein pathology.
This article is part of a special issue on Parkinson disease.