bluuebunny/crossref_metadata_2025_split huggingface dataset:
What impact does written information about fatigue have on patients with autoimmune rheumatic diseases? Findings from a qualitative study
Authors: Hart Ruth I. , Ng Wan‐Fai , Newton Julia L. , Hackett Katie L. , Lee Richard P. , Thompson Ben 
Published: November 2016

AbstractObjectivesAlthough fatigue is a common symptom for people with rheumatic diseases, limited support is available. This study explored the impact of written information about fatigue, focusing on a booklet, Fatigue and arthritis.MethodsThirteen patients with rheumatic disease and fatigue were recruited purposively from a rheumatology outpatient service. They were interviewed before and after receiving the fatigue booklet. Two patients, plus six professionals with relevant interests, participated in a focus group. Transcripts were analysed thematically and a descriptive summary was produced.ResultsInterviewees consistently reported that fatigue made life more challenging, and none had previously received any support to manage it. Reflecting on the booklet, most said that it had made a difference to how they thought about fatigue, and that this had been valuable. Around half also said that it had affected, or would affect, how they managed fatigue. No one reported any impact on fatigue itself. Comments from interviewees and focus group members alike suggested that the research process may have contributed to the changes in thought and behaviour reported. Its key contributions appear to have been: clarifying the booklet's relevance; prompting reflection on current management; and introducing accountability.ConclusionsThis study indicated that written information can make a difference to how people think about fatigue and may also prompt behaviour change. However, context appeared to be important: it seems likely that the research process played a part and that the impact of the booklet may have been less if read in isolation. Aspects of the research appearing to facilitate impact could be integrated into routine care, providing a pragmatic (relatively low‐cost) response to an unmet need.
A matrix rational Lanczos method for model reduction in large‐scale first‐ and second‐order dynamical systems
Authors: Barkouki H. , Bentbib A.H. , Jbilou K. 
Published: November 2016

SummaryIn the present paper, we describe an adaptive modified rational global Lanczos algorithm for model‐order reduction problems using multipoint moment matching‐based methods. The major problem of these methods is the selection of some interpolation points. We first propose a modified rational global Lanczos process and then we derive Lanczos‐like equations for the global case. Next, we propose adaptive techniques for choosing the interpolation points. Second‐order dynamical systems are also considered in this paper, and the adaptive modified rational global Lanczos algorithm is applied to an equivalent state space model. Finally, some numerical examples will be given.
Mixed Arlequin method for multiscale poromechanics problems
Authors: Sun WaiChing , Cai Zhijun , Choo Jinhyun 
Published: November 2016

SummaryAn Arlequin poromechanics model is introduced to simulate the hydro‐mechanical coupling effects of fluid‐infiltrated porous media across different spatial scales within a concurrent computational framework. A two‐field poromechanics problem is first recast as the twofold saddle point of an incremental energy functional. We then introduce Lagrange multipliers and compatibility energy functionals to enforce the weak compatibility of hydro‐mechanical responses in the overlapped domain. To examine the numerical stability of this hydro‐mechanical Arlequin model, we derive a necessary condition for stability, the twofold inf–sup condition for multi‐field problems, and establish a modified inf–sup test formulated in the product space of the solution field. We verify the implementation of the Arlequin poromechanics model through benchmark problems covering the entire range of drainage conditions. Through these numerical examples, we demonstrate the performance, robustness, and numerical stability of the Arlequin poromechanics model. Copyright © 2016 John Wiley & Sons, Ltd.
Current controversies in prenatal diagnosis 3: industry drives innovation in research and clinical application of genetic prenatal diagnosis and screening
Authors: Evans Mark I. , Vermeesch Joris Robert 
Published: November 2016

What's already known about this topic?

Innovation and technological development have commonalities across all disciplines in terms of process, evaluation, and incorporation into use.
Many technologies have evolved through traditional methods such as research grant funding, individual, and multicenter trials, followed by eventual introduction into common practice. Others have been significantly sped up by industrial resources and drive.
What does this study adds?

The development of basic new concepts and procedures will very like continue to reside the academic environment.
As the pace of technological development has rapidly accelerated and academic support for such work has significantly diminished, corporate involvement, sponsorship, and partnering have become much more common and, particularly for laboratory techniques, are necessary to achieve progress at a rapid pace.
There is a balance that needs to be respected between the benefits and constraints of such industrial involvement that will require compromise on both sides to achieve an optimal environment.
Designing for Family Science Explorations Anytime, Anywhere
Authors: LUCE MEGAN R. , GOLDMAN SHELLEY , VEA TANNER 
Published: November 2016

ABSTRACTFamilies play an important role in informal science learning, but they may need supports for engaging in science that is exploratory, inquiry based, and builds on family practices. We designed resources that frame scientific sensemaking as an active and playful process of exploration in which family members are coparticipants. This approach contrasts with more traditional school‐like canonical patterns of engagement in family science conversations where adults state facts and provide explanations to children. TheAnytime, Anywhereresources were designed to locate phenomena of interest in outdoor settings and cue families about how they might engage playfully in exploration by using sensemaking activities and conversation starters. We analyzed families’ video‐recorded activities and interviews as they field‐tested the resources at a coastal beach. The analysis shows families engaged in three features of scientific sensemaking, both in response to our designed activities and spontaneously. They elicited ideas and mechanistic processes, made hypotheses, and experimented to test ideas. We propose emerging design recommendations forAnytime, Anywherefamily scientific sensemaking activities, which can inform learning design in a variety of settings.
Experimental study on seismic performance of steel plate reinforced concrete tubes under cyclic loading
Authors: Wang Bin , Jiang Huanjun 
Published: November 2016

SummaryIn recent years, steel plate reinforced concrete (SPRC) tubes have been applied in super‐tall buildings increasingly in China Mainland. However, there has been very limited information about the damage behavior of such kind of composite tube subjected to the earthquake. This paper presents the quasi‐static tests on three 1/5‐scaled specimens including one steel reinforced concrete tube and two SPRC tubes with different steel plate ratio designed according to the current design codes and engineering practice to evaluate their seismic performance under cyclic lateral loading. The damage modes, hysteretic behavior, strength, deformation capacity, strength and stiffness degradation, shear deformation, and strain distribution of the specimens are discussed. The test results show that compared with the steel reinforced concrete tube, the seismic performance of the SPRC tube is significantly enhanced, and the effect of steel plate ratio on the seismic performance of the SPRC tube is not significant. Because of the lateral restraint effect of the concrete on the steel plate, there is no buckling behavior in the steel plate during the whole loading process.
Accuracy of ultrasound in prediction of rectosigmoid infiltration in epithelial ovarian cancer
Authors: Zikan M. , Fischerova D. , Semeradova I. , Slama J. , Dundr P. , Weinberger V. , Dusek L. , Cibula D. 
Published: November 2016

ABSTRACTObjectiveTo examine prospectively the accuracy of ultrasound in predicting rectosigmoid tumor infiltration in patients with epithelial ovarian cancer.MethodsPatients referred for a suspicious pelvic mass between 2012 and 2014 were examined by ultrasound following the standard protocol for assessment of tumor infiltration. Of the 245 patients examined, 191 had proven ovarian cancer and underwent primary surgery and were included in the analysis. Patients with apparently benign or inoperable disease were excluded. Rectosigmoid infiltration was evaluated by histopathology or according to perioperative findings. Clinical, pathological and laboratory parameters were analyzed as factors potentially affecting the sensitivity and specificity of sonography.ResultsThe sensitivity of ultrasound in detecting rectosigmoid infiltration in patients with ovarian cancer was 86.3%, with specificity of 95.8%, positive predictive value of 92.6%, negative predictive value of 91.9% and overall accuracy of 92.1%.ConclusionUltrasound is a highly accurate method for detecting rectosigmoid tumor infiltration in ovarian cancer patients, and thus, can be used for planning adequate management, including patient consultation, surgical team planning, suitable operating time and postoperative care. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Monitoring the EU protected Geomalacus maculosus (Kerry Slug): what are the factors affecting catch returns in open and forested habitats?
Authors: Johnston Erin , Kindermann Gesche , O'Callaghan Jack , Burke Daniel , McLaughlin Cillian , Horgan Sinéad , Mc Donnell Rory , Williams Christopher , Gormally Michael 
Published: November 2016

AbstractGeomalacus maculosus is a slug species protected under EU law with a distribution limited to the west of Ireland and north‐west Iberia. The species, originally thought to be limited within Ireland to deciduous woodland and peatland, has been found in a number of commercial conifer plantations since 2010. While forest managers are now required to incorporate the protection of the species where it is present, no clear species monitoring protocols are currently available. This study examines the efficacy of De Sangosse refuge traps across three habitats frequently associated with commercial forest plantations in Ireland and compares them with hand searching, a commonly used method for slug monitoring. Catch data during different seasons and under different weather conditions are also presented. Results indicate that autumn is the optimal time for sampling G. maculosus but avoiding extremes of hot or cold weather. While refuge traps placed at 1.5 m on trees in mature conifer plantations and directly on exposed rock in blanket peatlands result in significantly greater catches, hand searching is the most successful approach for clear‐fell areas. Hand searches in clear‐fell preceded by rain are likely to result in greater numbers caught. The results of this study form, for the first time, the basis for G. maculosus monitoring guidelines for forestry managers.
Amido‐Amine‐Based Cationic Gemini Surfactants: Thermal and Interfacial Properties and Interactions with Cationic Polyacrylamide
Authors: Shakil Hussain S. M. , Kamal Muhammad Shahzad , Sultan Abdullah S. 
Published: November 2016

AbstractExperimental studies were conducted to investigate thermal and interfacial properties of two in‐house synthesized amido‐amine‐based cationic gemini surfactants namely: dodecanoic acid [3‐({4‐[(3‐dodecanoylamino‐propyl)‐dimethyl‐amino]‐butyl}‐dimethyl‐amino)‐propyl]‐amide dibromide (12‐4‐12) and dodecanoic acid [3‐({6‐[(3‐dodecanoylamino‐propyl)‐dimethyl‐amino]‐hexyl}‐dimethyl‐amino)‐propyl]‐amide dibromide (12‐6‐12). Thermogravimetric analysis showed the excellent thermal stability of surfactants and no structural degradation was observed at temperatures up to 250 °C. The long‐term thermal stability of the surfactants was investigated with the aid of spectroscopic techniques such as nuclear magnetic resonance (NMR (1H and13C) and Fourier transform infrared (FTIR) spectroscopy. Both surfactants were found to be thermally stable, and no changes in structure were observed after aging for 10 days at 90 °C. The interfacial tension of the surfactants was measured at three different temperatures (30, 60, and 80 °C), and the results showed a decrease in interfacial tension with increasing temperature and increasing spacer length of the surfactants. Rheological measurements were used to assess the interactions between the cationic gemini surfactant and cationic polyacrylamide. The addition of cationic surfactant reduced the viscosity and storage modulus of the polymer at low shear rate and frequency due to surfactant–polymer interactions and charge screening. The investigated surfactant–polymer system has great potential in high‐temperature carbonate reservoirs, where conventional anionic surfactants are not recommended due to high adsorption.
Quantification of Antioxidant Ability Against Lipid Peroxidation with an ‘Area Under Curve’ Approach
Authors: Bakır Temelkan , Sönmezoglu İnci , Apak Reşat 
Published: November 2016

AbstractWhen oxygen is passed through a linoleic acid (LA) emulsion containing copper(II), primary (hydroperoxides) and secondary oxidation products (aldehydes and ketones) are formed, monitored by ferric thiocyanate (Fe(III)‐SCN) and thiobarbituric acid reactive substances (TBARS) colorimetry, respectively. As total antioxidant capacity (TAC) against lipid peroxidation was not quantified before, both methods were adapted to an ‘area under curve (AUC)’ approach. LA peroxidation followed pseudo‐first order kinetics in aerated emulsions. Absorbance changes as a function of incubation time exhibited sigmoidal curves, enabling the calculation of ‘area under curve’ (AUC) and net AUC = AUCblank−AUCsample, standard calibration curve as net AUC versus concentration, and trolox‐equivalent antioxidant capacity of the tested compounds. Garlic extract showed an antioxidative effect on hydroperoxide formation, but a prooxidative effect on TBARS. Although inhibition of lipid peroxidation was described qualitatively before, it was not evaluated quantitatively, e.g., the trolox‐equivalent antioxidant capacities (TEAC values) of antioxidants with respect to their inhibitive effect against lipid peroxidation were not calculated and compared. Additionally, real‐time monitoring of lipid oxidation products requires highly sophisticated but costly instrumental techniques, but no single oxidation product is a direct measure of lipid oxidation or its antioxidative prevention. The AUC approach is the first quantitative method measuring antioxidant protection against lipid oxidation, with a slightly different order of antioxidative effectiveness from reductive assays because of interfacial effects.
Effect of Spray‐Dried Flavonoid Microparticles on Oxidative Stability of Methyl Linoleate as Lipid Model System
Authors: Palma Manuel , Márquez‐Ruiz Gloria , García Paula , Holgado Francisca , Vergara Cristina , Giménez Begoña , Robert Paz 
Published: November 2016

AbstractMicroencapsulated quercetin (Q) and epicatechin (E) were prepared by spray‐drying using inulin (IN) as encapsulating agent (Q–IN and E–IN) as well as with Capsul (C) as channelizing agent (Q–IN–C and E–IN–C). Microparticles were added to methyl linoleate (ML) and results showed that Q microparticles markedly improved its oxidative stability by increasing the induction period values and delaying the formation of oxidation compounds, as determined by high‐performance size‐exclusion chromatography, with respect to E microparticles, thus suggesting the importance of flavonoid C‐ring substitution. Remaining levels of Q in the lipid system throughout oxidation of ML added with Q microparticles seemed to show two releasing zones: the first one corresponds to the equilibrium zone, when Q released from microparticles replaces Q that is being degraded; the second zone corresponds to the degradation of Q, when the release rate of the encapsulated Q is slower than its degradation rate. In contrast, E microparticles showed only one zone corresponding to the release of surface E. The end of the induction period was in line with the exhaustion of Q and E and the initiation of formation of advanced oxidation products (polymers). In conclusion, Q microparticles have a potential application to extend the shelf‐life of lipid matrixes.
Blood‐based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic
Authors: O'Bryant Sid E. , Mielke Michelle M. , Rissman Robert A. , Lista Simone , Vanderstichele Hugo , Zetterberg Henrik , Lewczuk Piotr , Posner Holly , Hall James , Johnson Leigh , Fong Yiu‐Lian , Luthman Johan , Jeromin Andreas , Batrla‐Utermann Richard , Villarreal Alcibiades , Britton Gabrielle , Snyder Peter J. , Henriksen Kim , Grammas Paula , Gupta Veer , Martins Ralph , Hampel Harald ,   Biofluid Based Biomarker Professional Interest Area
Published: November 2016

AbstractThe last decade has seen a substantial increase in research focused on the identification of blood‐based biomarkers that have utility in Alzheimer's disease (AD). Blood‐based biomarkers have significant advantages of being time‐ and cost‐efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood‐based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public‐private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases.
A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics
Authors: Schmitz Natalie S. , Krach Linda E. , Coles Lisa D. , Mishra Usha , Agarwal Suresh K. , Cloyd James C. , Kriel Robert L. 
Published: November 2016

AbstractBackgroundAbrupt discontinuation of baclofen can result in a potentially severe withdrawal syndrome. The current treatment for baclofen withdrawal is inadequate, resulting in a critical need to develop an alternative method to prevent or treat this withdrawal syndrome.ObjectiveTo evaluate the safety profile and pharmacokinetics of oral (PO) and investigational intravenous (IV) baclofen formulations at clinically relevant doses.DesignRandomized, open‐label, dose‐escalation, crossover study.SettingContract Research Organization (CRO).MethodsThree cohorts of 12 healthy adults received single doses of PO baclofen (10 mg, 15 mg or 20 mg) and 10‐minute infusions of IV baclofen (7.5 mg, 11.5 mg, or 15 mg) with a minimum 48‐hour wash‐out period. The third cohort also received a 60‐minute infusion of 15 mg IV baclofen after an additional 48‐hour wash‐out period.Main Outcome MeasuresSubjects were observed in a CRO for 24 hours after each dose of baclofen, and were assessed for nystagmus, ataxia, and sedation. Blood samples were collected from 0 to 24 hours and analyzed for baclofen concentration using high‐performance liquid chromatography−mass spectroscopy. Noncompartmental pharmacokinetic analyses were performed. Dose linearity and proportionality was assessed using 2‐way repeated‐measures analysis of variance and a power model analysis.ResultsNone of the PO or IV doses resulted in significant sedation compared to baseline. All subjects could perform tandem gait after each baclofen dose. The most common side effect, transient mild nystagmus, was noted in 4 of 36 and in 13 of 36 subjects after PO and IV administration, respectively. This was likely related to increased maximum concentrations (Cmax). After the 20 mg PO and 15 mg IV doses, mean Cmax levels were 255 and 722 ng/mL and half‐lives were 5.24 and 5.79 hours for PO and IV baclofen, respectively. The mean oral bioavailability for the 20‐mg PO dose was approximately 80%.ConclusionsAll PO and IV doses of baclofen were well tolerated clinically. The 80% bioavailability suggests that a 20% reduction in IV dose will produce comparable total drug exposures to that of the PO dose. When PO therapy is interrupted, bridging with IV baclofen may be feasible.Level of EvidenceII
Cenozoic history of topography in southeastern Gorny Altai: thermochronology and resistivity and gravity records
Authors: Dobretsov N.L. , Buslov M.M. , Vasilevsky A.N. , Vetrov E.V. , Nevedrova N.N. 
Published: November 2016

Abstract
The Central Asian Orogen was reactivated in the Cenozoic, which gave rise to mountain systems and sedimentary basins, strike-slip and thrust faults, ramps, and rift basins under the far-field effect of the India–Eurasia collision. Pre-Cenozoic structures, as well as the superposed Cenozoic deformation, are traceable in the gravity pattern. Analysis and correlation of stratigraphic, tectonic, geomorphological, and geophysical (resistivity and gravity) data from Gorny Altai and tectonic modeling on the basis of apatite fission-track thermochronology show that vertical motions have been the most active for the past 5 Ma. The uplift and subsidence produced, respectively, the Chulyshman and Ukok Plateaus with high mountains around and the the Kurai–Chuya basin between them. Gravity data suggest the existence of Late Carboniferous, Jurassic, and Cretaceous rocks found in tectonic wedges around the basin at the base of its sedimentary fill.
Geochemical, isotopic, and geochronological evidence for subsynchronous island-arc magmatism and terrigenous sedimentation (Predivinsk terrane of the Yenisei Ridge)
Authors: Nozhkin A.D. , Dmitrieva N.V. , Likhanov I.I. , Serov P.A. , Kozlov P.S. 
Published: November 2016

Abstract
In this study we present data on the geologic setting, geochemical and isotopic compositions, timing and P-T conditions of metamorphism of Neoproterozoic terrigenous metasediments, and associated island-arc metavolcanics of the Predivinsk terrane of the Yenisei Ridge. Relatively immature terrigenous rocks were eroded from a local source which is associated with island-arc magmatic complexes. The geochronological constraints indicate that the terrigenous rocks were eroded from juvenile crustal sources represented primarily by magmatic rocks, which are similar to those of the Predivinsk terrane. This is supported by a similar range of model ages, positive εNd values of terrigenous and magmatic rocks, and correspondence between the concordant ages of detrital zircons from metasedimentary rocks (610–640 Ma) and the U–Pb ages of zircons from rhyolites (ca. 620–640 Ma) from two suites within different sequences. The P-T conditions for volcanosedimentary rocks of the Predivinsk terrane correspond to the epidote-amphibolite facies and the transition from epidote-amphibolite to amphibolite facies. The most likely age of metamorphism due to Vendian accretion/collision events is given by Ar–Ar dates of 600–610 Ma.