bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue in Patients with Autoimmune Thyroid Diseases
Authors: Jovanovic Zorica , Miletic-Drakulic Svetlana , Toncev Gordana , Mihaljevic Olgica , Djukic Svetlana , Jevdjic Jasna , Zivancevic-Simonovic Snezana 
Published: June 2016

Abstract
Fatigue is a common feature in a wide variety of chronic inflammatory and autoimmune diseases, but fatigue in autoimmune thyroid disease (AITD) has not been investigated so far. The aim of this study was to examine fatigue in patients with AITD and to analyse the correlation between fatigue and the serum concentrations of thyroid antibodies, thyroid function and depression. This cross-sectional clinical study included 62 patients with increased concentrations of thyroperoxidase antibodies (TPOAbs) as confirmation of AITD and 52 healthy individuals who were negative for thyroid antibodies; all controls were euthyroid. Thyroid antibodies, free thyroxine and thyroid-stimulating hormone were measured in the sera of all subjects. The Fatigue Severity Scale was used to measure the severity of fatigue; the level of depression was measured by the Beck Depression Inventory. Eight (12.9%) patients had evident fatigue, 7 (11.3%) patients had fatigue limit values, and 47 (75.8%) patients had no fatigue. The frequency of fatigue was highly significant and almost three times higher in the AITD patients compared to the control group, in which only 2 (3.8%) patients had evident fatigue. The majority of patients with fatigue had normal thyroid function, and only one (1.6%) patient had overt hypothyroidism. Seven (11.3%) patients had both fatigue and depression, whereas one (1.6%) patient had fatigue without depression. We did not find significant correlations between fatigue and the concentrations of thyroid antibodies, but we found statistically significant correlations between fatigue and depression in AITD patients.
Galectin-3 Deletion Enhances Visceral Adipose Tissue Inflammation and Dysregulates Glucose Metabolism in Mice on a High-Fat Diet
Authors: Jeftic Ilija , Miletic-Kovacevic Marina , Jovicic Nemanja , Pantic Jelena , Arsenijevic Nebojsa , Lukic Miodrag L. , Pejnovic Nada 
Published: June 2016

Abstract
Obesity and type 2 diabetes mellitus (T2DM) constitute major health problems worldwide. Increased visceral adiposity enhances the risk of insulin resistance and type 2 diabetes. The mechanisms involved in obesity-associated chronic inflammation in metabolic tissues (metaflammation) that lead to insulin resistance and dysregulated glucose metabolism are incompletely defined. Galectin-3 (Gal-3), a β-galactoside-binding lectin, modulates immune/inflammatory responses and specifically binds to metabolic danger molecules. To dissect the role of Gal-3 in obesity and diabetes, Gal-3-deficient (LGALS3-/-) and wild-type (WT) C57Bl/6 male mice were placed on a high-fat diet (HFD, 60% kcal fat) or a standard chow diet (10% kcal fat) for 6 months and metabolic, histological and immunophenotypical analyses of the visceral adipose tissue were performed. HFD-fed LGALS3-/- mice had higher body weights and more body weight gain, visceral adipose tissue (VAT), hyperglycaemia, hyperinsulinemia, insulin resistance and hyperlipidemia than diet-matched WT mice. Compared to WT mice, the enlarged VAT in obese LGALS3-/- mice contained larger adipocytes. Additionally, we demonstrate enhanced inflammation in the VAT of LGALS3-/- mice compared with diet-matched WT mice. The VAT of LGALS3-/- mice fed a HFD contained more numerous dendritic cells and proinflammatory F4/80+CD11c+CD11b+ and F4/80high macrophages. In contrast to WT mice, the numbers of CXCR3+ and CD8+ T cells were increased in the VAT of Gal-3-deficient mice after 6 months of high-fat feeding. We provide evidence that Gal-3 ablation results in enhanced HFD-induced adiposity, inflammation in the adipose tissue, insulin resistance and hyperglycaemia. Thus, Gal-3 represents an important regulator of obesity-associated immunometabolic alterations.
Unusual Respiratory Manifestations of Ankylosing Spondylitis – A Case Report
Authors: Cekerevac Ivan , Cupurdija Vojislav , Novkovic Ljiljana , Lazic Zorica , Petrovic Marina , Gajovic Olgica , Susa Romana 
Published: June 2016

Abstract
A male patient, 54 years old, was initially admitted to the hospital because of fatigue he felt during the last month and swelling of the lower legs. Upon hospital admittance, gas exchange analysis showed global respiratory failure: pO2=6.1 kPa, pCO2=10.9 kPa, pH=7.35, A-a gradient = 1.0. Due to the existence of hypercapnia and decompensated respiratory acidosis, the patient was connected to a device for non-invasive mechanical ventilation. Reduced chest mobility was noticed, and the respiratory index value was decreased. Radiographs of the chest and thoracic and lumbo-sacral spine showed marked changes on the spine attributable to ankylosing spondylitis (AS). Radiographs of the sacroiliac joints showed reduced sacroiliac joint intraarticular space with signs of subchondral sclerosis. The diagnosis of AS was set on the basis of New York Criteria (bilateral sacroiliitis, grade 3) and clinical criteria (back pain, lumbar spine limitation and chest expansion limitation). HLA typing (HLA B27 +) confirmed the diagnosis of AS. Pulmonary function test proved severe restrictive syndrome. Polysomnography verified the existence of severe obstructive sleep apnoea (AHI =73). This was a patient with newly diagnosed AS, with consequent severe restrictive syndrome and global respiratory failure with severe obstructive sleep apnoea. Thee patient was discharged from the hospital with a NIV (global respiratory failure) device for home use during the night.
A semiparametric nonlinear quantile regression model for financial returns
Authors: Avdulaj Krenar , Barunik Jozef 
Published: June 2016

AbstractAccurately measuring and forecasting value-at-risk (VaR) remains a challenging task at the heart of financial economic theory. Recently, quantile regression models have been used successfully to capture the conditional quantiles of returns and to forecast VaR accurately. In this paper, we further explore nonlinearities in data and propose to couple realized measures with the nonlinear quantile regression framework to explain and forecast the conditional quantiles of financial returns. The nonlinear quantile regression models are implied by the copula specifications and allow us to capture possible nonlinearities, tail dependence, and asymmetries in the conditional quantiles of financial returns. Using high frequency data that covers most liquid US stocks in seven sectors, we provide ample evidence of asymmetric conditional dependence with different levels of dependence, which are characteristic for each industry. The backtesting results of estimated VaR favour our approach.
Unravelling the diffraction pattern of a twin. I. Fundamentals
Authors: Nespolo Massimo 
Published: June 2016

Abstract
Unravelling the diffraction pattern of a twin consists in assigning each observed intensity to the individuals they come from. The unravel process consists in (1) recognizing the presence of twinning; (2) identifying the twin operations; (3) re-indexing the diffraction pattern of the twin. In case of twin lattice quasi symmetry (TLQS) twinning, the presence of twinning appears in the splitting of the diffractions. For twin lattice symmetry (TLS) twinning, instead, the presence of twinning can be overlooked, but the large fraction of unobserved diffractions and the unusual and complex non-space group absences should draw the investigator’s attention to the possible presence of twinning. Some general criteria to identify the presence of twinning are presented and discussed with examples taken from the literature.
Adducts of urea with pyrazines
Authors: Döring Cindy , Taouss Christina , Strey Mark , Pinkert Lukas , Jones Peter G. 
Published: June 2016

Abstract
The adducts urea:2,3-dimethylpyrazine (1:1) (1), urea:2-methylpyrazine (2:1) (2), urea:2,6-dimethylpyrazine (2:1) (3), urea:2,5-dimethylpyrazine (2:3) (4) and urea:2,5-dimethylpyrazine (2:1) (5), together with the related adduct methylthiourea:2-methylpyrazine (1:1) (6), were prepared and their structures determined. In all cases, the basic motif of the packing is a urea (or thiourea for 6) ribbon consisting of linked

R
2
2

${\rm{R}}_2^2$

(8) rings, to which the pyrazines are often attached by bifurcated hydrogen bond systems. Adducts 1–3 present standard packing patterns of 1:1 or 2:1 urea solvates. Adduct 4 consists of layers of standard 1:1 ribbons, between which are regions of interspersed pyrazines, connected to the main layers by C–H⋯N interactions. Adduct 5 contains the standard ribbons linked by pyrazines in one direction and (urea⋯pyrazine⋯urea) spacers in the other direction. The methylthiourea adduct 6 consists of the usual ribbons with pyrazines attached by two-centre hydrogen bonds (the methyl substituent blocks the formation of bifurcated systems).
MANAGEMENT OF ENDOCRINE DISEASE: Imaging for the diagnosis of malignancy in incidentally discovered adrenal masses: a systematic review and meta-analysis
Authors: Dinnes Jacqueline , Bancos Irina , Ferrante di Ruffano Lavinia , Chortis Vasileios , Davenport Clare , Bayliss Susan , Sahdev Anju , Guest Peter , Fassnacht Martin , Deeks Jonathan J , Arlt Wiebke 
Published: June 2016

ObjectiveAdrenal masses are incidentally discovered in 5% of CT scans. In 2013/2014, 81 million CT examinations were undertaken in the USA and 5 million in the UK. However, uncertainty remains around the optimal imaging approach for diagnosing malignancy. We aimed to review the evidence on the accuracy of imaging tests for differentiating malignant from benign adrenal masses.DesignA systematic review and meta-analysis was conducted.MethodsWe searched MEDLINE, EMBASE, Cochrane CENTRAL Register of Controlled Trials, Science Citation Index, Conference Proceedings Citation Index, and ZETOC (January 1990 to August 2015). We included studies evaluating the accuracy of CT, MRI, or18F-fluoro-deoxyglucose (FDG)-PET compared with an adequate histological or imaging-based follow-up reference standard.ResultsWe identified 37 studies suitable for inclusion, after screening 5469 references and 525 full-text articles. Studies evaluated the accuracy of CT (n=16), MRI (n=15), and FDG-PET (n=9) and were generally small and at high or unclear risk of bias. Only 19 studies were eligible for meta-analysis. Limited data suggest that CT density >10HU has high sensitivity for detection of adrenal malignancy in participants with no prior indication for adrenal imaging, that is, masses with ≤10HU are unlikely to be malignant. All other estimates of test performance are based on too small numbers.ConclusionsDespite their widespread use in routine assessment, there is insufficient evidence for the diagnostic value of individual imaging tests in distinguishing benign from malignant adrenal masses. Future research is urgently needed and should include prospective test validation studies for imaging and novel diagnostic approaches alongside detailed health economics analysis.
El concepto de sobredeterminación en Althusser
Authors: Ambriz Arévalo Gerardo 
Published: June 2016

Debates en torno al marxismo se han dado muchos, pero no todos han generado tanta discordia como el que se dio respecto a las obras tempranas de Althusser, en las cuales se asegura que el pensamiento de Marx se divide tajantemente en una etapa de juventud que está fuertemente influida por Hegel y Feuerbach, y en otra de madurez que implica tanto una ruptura con dichas influencias, como una forma científica de entender y explicar los problemas político-sociales. En este trabajo se analizarán algunos de los argumentos que presentó Althusser, pero poniendo énfasis en el concepto de sobredeterminación, por ser el concepto que mejor refleja el corte epistemológico que postuló sobre Marx.http://dx.doi.org/10.15304/ag.35.2.2847
Itinerários na correspondência entre Oliveira Lima e Fidelino de Figueiredo (1912-1928)
Authors: Malatian Teresa 
Published: June 2016

Este artigo pretende analisar a correspondência trocada por M. de Oliveira Lima e Fidelino de Figueiredo, como parte de sociabilidades intelectuais construídas por meio da Sociedade Portuguesa de Estudos Históricos, entre 1912 e 1928. Os conceitos de geração, itinerário e projeto foram aqui utilizados com base nos aportes de P. Bourdieu e J.F.Sirinelli na análise do campo intelectual em que se inseriram esses autores. Trata-se de um sistema regido por relações específicas, com instâncias particulares de seleção e consagração intelectual. Nesse sentido, considera-se que a autonomia do campo intelectual é relativa, por ser afetado não apenas por relações específicas, mas também pelas pressões políticas, econômicas e sociais que interferem no projeto criador, desde sua proposição até as instâncias de consagração de seu autor. O principal projeto historiográfico analisado foi o das obras D. Pedro e D. Miguel e D. Miguel no trono, escritas por M. de Oliveira Lima.
La economía de León en Europa (1986-2011): sector de tecnología de la información y la comunicación en León
Authors: Abril David 
Published: June 2016

La evolución de las TIC (Tecnologías de la Información y Comunicación) en todo el mundo ha sido vital y exponencial durante las últimas décadas. En la provincia de León el sector nació en 1986 y ha tenido una gran evolución hasta nuestros días. Actualmente es uno de los sectores principales y más importantes por su carácter transversal. El objetivo de este artículo es delimitar el sector y describir su evolución con el fin de entender el desarrollo que ha tenido hasta nuestros días y su importante situación actual. Además de señalar aquellas organizaciones que ayudan a su promoción y una exposición de sus fortalezas y debilidades.The IT evolution in the world has been essential and exponential during the last decades. In the province of León the IT sector was born in 1986 and it has been a great evolution to nowadays. Now IT is one of the main sectors because its cross-sector nature. The main goal of this paper is to delimite the sector in the province of León and the evolution of the sector in order to understand the development and the importance of the IT sector to our days. Besides to point out the supporting organizations of the sector and explain the strengths and weaknesses of it.
El sector del transporte en León. Infraestructuras y servicios
Authors: Alvarez Folgueras Cristina 
Published: June 2016

En este trabajo se concretan, para la provincia de León, las principales características del transporte, tanto en cuanto a las infraestructuras de las que dispone como a los servicios que ofrece. Revisamos la evolución de las inversiones realizadas en el sector ferroviario, de transporte por carretera y por avión, con especial atención a las responsabilidades de cada Administración y a las previsiones futuras basadas en distintos Planes de Infraestructuras e Informes. En la última parte del trabajo abordamos el impacto de los servicios de transporte en la provincia, tanto en términos de Valor Añadido como en términos de Empleo y repasamos diversos indicadores que, indirectamente, informan de la evolución del sector. Finalmente, se aborda la estructura geográfica de las principales relaciones del transporte leonés con otras provincias.In this work we specified, for the province of Leon, the main features of transport, both in terms of infrastructure as in terms of services offered. We review the evolution of investments in the railway sector, the road transport and the transport by air, with special attention to the responsibilities of each Administration and to the future projections based on different Infrastructure Plans and Reports. In the last part of the paper we address the impact of transport services in the province, both in terms of value added and in terms of employment and review several indicators that indirectly informed of the sector’s performance. Finally, the geographical structure of the main transport relations of Leon with other provinces are also addressed.
Evolución del perfil sectorial del comercio exterior en la provincia de León, 1995-2014 = Foreign trade sector evolution in the province of León 1995-2014
Authors: Placer Galán José Luis 
Published: June 2016

El notable crecimiento del comercio exterior de España en las últimas décadas también se ha producido en una economía tan orientada al mercado interior como la de la provincia de León. El objetivo de este trabajo es doble: averiguar la evolución del peso del comercio exterior en el conjunto de la actividad productiva leonesa, y el perfil sectorial de sus flujos comerciales durante el período 1995-2014.El análisis realizado permite señalar que en los últimos veinte años la actividad productiva orientada a los mercados internacionales se ha duplicado, especialmente en los últimos cinco años. Por otra parte, el perfil sectorial exportador ha variado notablemente pasando de ser mayoritariamente de productos químico-farmacéuticos y extractivos a serlo actualmente de bienes de equipo eléctricos y de manufacturas metálicas. Sin embargo, las importaciones, que tienen un mayor grado de diversificación que las exportaciones, han mantenido un perfil sectorial similar en todo el período, concentrado en legumbres y, en menor medida, en bienes de equipo eléctricos y de manufacturas metálicas.In the last decades foreign trade has experienced a significant growth both in Spain and Leon economies, whereas the latter has always been characterized by a strong focus on domestic trade. The goal of this paper is dual: find out the evolution of foreign trade importance within the whole productive activity in Leon and sector profile of its trade flows during the period from 1995 to 2014.On the one hand, the analysis carried out highlights that productive activities focused on foreign trade have doubled in the last twenty years, especially in the recent five. On the other hand, export sectors have changed mainly, from exporting pharmaceutical chemistry products and extractors to currently exporting electrical equipment and metal assembly. However, import sectors that are more diversified than export, have maintained a similar sector profile during the full period analysed. Import sectors in Leon are mainly focused on legumes and in a smaller proportion on electrical appliance equipment and metal assembly.
A Dual Model to Predict the Peronospora sparsa Sporulation in Rose Based on the Plant Microclimate
Authors: Filgueira Juan José , Velasquez Katherin 
Published: June 2016

<p class="Default"> Las rosas son el producto más importante de exportación de la industria de flores en Colombia, y el mildeo producido por <em>Peronospora sparsa </em>Berkeley es la enfermedad más limitante. La predicción de ataque es una herramienta importante para prevenir y combatir la enfermedad, disminuyendo el costo de producción de la flor. <em>P. sparsa </em>depende de las condiciones microclimáticas para su desarrollo biológico. En este trabajo, se presenta un modelo dual para predecir la esporulación, basado en el conocimiento de la temperatura y la hu­medad relativa cerca de la planta (microclima) durante la noche anterior a la predicción, y permitiendo un nivel de fiabilidad por encima del 95% en la determinación de la esporulación del parásito y con esa información tomar una decisión sobre la aplicación de los fungicidas en el cultivo.</p>
Caracterización Morfo Agronómica de Híbridos Provenientes del Cruzamiento entre Especies Diploides de Papa
Authors: Rodríguez Rodríguez Oscar Jair , Rodríguez Molano Luis Ernesto , Cotes Torres José Miguel 
Published: June 2016

<p>Se realizó la caracterización morfoagronómica de 2285 genotipos provenientes de 20 familias obtenidas a partir de cruzamientos entre progenitores diploides, cultivados y silvestres de las especies <em>Solanum tuberosum </em>grupo Phureja, S<em>olanum stenotomun </em>subsp. <em>stenotomun, Solanum stenotomun </em>subsp. <em>goniocalyx y Solanum </em><em>bukasovii. </em>El experimento fue establecido en el municipio de Facatativa (Cundinamarca) y se evaluaron 35 características en cinco etapas del cultivo. Para el registro de los datos se utilizó la guía para las caracterizaciones morfológicas básicas en colecciones de papas nativas del centro internacional de la papa. Al registrarse variables mixtas se utilizó la distancia genética de Gower. Se identificaron cinco grupos principales, en el grupo donde se ubicaron principalmente los cruzamientos entre variedades, se observó un aumento en la cantidad de pares de foliolos laterales, en el grupo donde se ubicó la variedad Guaneña y algunos cruzamientos de <em>S. stenotomun </em>subsp. <em>goniocalix se </em>observaron brotes violeta en forma predominante. Los cruzamientos de <em>S. bukasovii </em>presentaron color de flor lila y/o morado intenso, hábito de crecimiento semiarrosetado y bajos rendimientos. En los cruzamientos de <em>S. stenotomum </em>subsp <em>stenotonum </em>se presentaron tubérculos de piel roja y ojos profundos.</p>
RECUPERAÇÃO DA ÁREA DEGRADADA E PLANEJAMENTO AMBIENTAL DO PARQUE GENTIL DINIZ – CONTAGEM/MG
Authors: Souza Juliana Batista de , Rios Ana Elisa Rocha , Nascimento Eduarda Moreira , Fonseca Gabriela Oliveira , Macedo Jessica Lane Alves de , Vianini Kelvin Nunes , Almeida Thaiane Larissa Nunes de 
Published: June 2016

<p>O planejamento ambiental pode ser considerado um processo sistêmico com objetivos e metas de caráter ambiental, sendo uma ferramenta essencial para o desenvolvimento das cidades e para a expansão urbana. Nesse contexto, a gestão dos recursos hídricos é um dos itens vitais que deve ser considerado no planejamento, assim como áreas de preservação permanente, que segundo o código Florestal, são representadas pelas nascentes, margens de rios, cursos d’água, lagos, lagoas e reservatórios, topos de morros e encostas com declividade elevada, cobertos ou não por vegetação nativa; a vegetação é essencial na conservação desses recursos. Por isso, este estudo teve como objetivo a recuperação da área degradada e cursos d’água dentro do Parque Gentil Diniz, localizado na cidade de Contagem- MG. Para tanto, foi necessário recuperar a mata ciliar do Córrego das Acácias e identificar nascentes presentes no parque. Foram plantadas ao longo das margens do córrego 44 mudas de 12 espécies diferentes utilizando - se o método de Plantio Aleatório, além do cadastro das nascentes identificadas. De acordo com o monitoramento realizado, as mudas apresentaram desenvolvimento satisfatório e se adaptaram bem às condições do local. Duas nascentes foram identificadas, e dentre elas, uma encontrava-se seca. Foi ressaltada ainda a importância de conectar a sociedade com as áreas verdes presentes nas cidades.</p><p><span lang="X-NONE">Abstract</span></p><p><span lang="X-NONE">The </span>environmental planning can be considered a systemic process with goals and objectives of environmental characte<span lang="EN-US">r, being an essential tool for the development of cities and urban sprawl. In this context, the management of water resources is one of the vital items that must be considered in the planning, as well as permanent preservation areas which, according to the forest code, are represented by the headwater, banks of rivers, streams, lakes, ponds and reservoirs, the tops of hills and slopes with high slope, covered by native vegetation; the vegetation is essential to the conservation of these resources. Therefore, this study aimed at recovering of the degraded area and watercourses within the Gentil Diniz Park, located in Contagem- MG. For this purpose, it was necessary to recover the riparian stream of Acacias’s Creek and identify headwater within the park. 44 seedlings of 12 different species were planted along the banks of the stream using the method of Random Planting in addition to the registration of the identified sources. According to monitoring, the seedlings showed satisfactory development and have adapted well to local conditions. Two springs were identified, and one of them had dried. It was also highlighted the importance of connecting society with green areas present in cities.</span></p><pre> </pre>