bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructing the confluence zone between Laurentide and Cordilleran ice sheets along the Rocky Mountain Foothills, south‐west Alberta
Authors: Utting Daniel J. , Atkinson Nigel , Pawley Steven , Livingstone Stephen J. 
Published: October 2016

ABSTRACTLandform mapping near the Athabasca valley was fundamental to determining whether the Late Wisconsinan Laurentide and Cordilleran Ice Sheets (LIS, CIS) coalesced. In this paper we examine the detailed landform record using new LiDAR digital elevation and hillshade models of the area of confluence and eventual desuturing of these ice sheets. This work reveals an earlier more extensive Cordilleran advance before coalescence with the LIS. When the ice sheets coalesced, the flow pattern was dominated by ice flow along the mountain front, with Cordilleran ice flowing out of major trunk valleys but Laurentide ice flowing into the Foothills up smaller valleys. This flow pattern implies that when the ice sheets coalesced the CIS was already waning, or at least was not at its maximum. Deglaciation was interrupted by several re‐advances, probably related to the destabilizing effect of proglacial lakes along the ice margin.
Indirect Solid Freeform Fabrication of an Initiator‐Free Photocrosslinkable Hydrogel Precursor for the Creation of Porous Scaffolds
Authors: Houben Annemie , Pien Nele , Lu Xi , Bisi Francesca , Van Hoorick Jasper , Boone Matthieu N. , Roose Patrice , Van den Bergen Hugues , Bontinck Dirk , Bowden Tim , Dubruel Peter , Van Vlierberghe Sandra 
Published: October 2016

In the present work, a photopolymerized urethane‐based poly(ethylene glycol) hydrogel is applied as a porous scaffold material using indirect solid freeform fabrication (SFF). This approach combines the benefits of SFF with a large freedom in material selection and applicable concentration ranges. A sacrificial 3D poly(ε‐caprolactone) structure is generated using fused deposition modeling and used as template to produce hydrogel scaffolds. By changing the template plotting parameters, the scaffold channel sizes vary from 280 to 360 μm, and the strut diameters from 340 to 400 μm. This enables the production of scaffolds with tunable mechanical properties, characterized by an average hardness ranging from 9 to 43 N and from 1 to 6 N for dry and hydrated scaffolds, respectively. Experiments using mouse calvaria preosteoblasts indicate that a gelatin methacrylamide coating of the scaffolds results in an increased cell adhesion and proliferation with improved cell morphology.
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Hepatic function imaging using dynamic Gd‐EOB‐DTPA enhanced MRI and pharmacokinetic modeling
Authors: Ning Jia , Yang Zhiying , Xie Sheng , Sun Yongliang , Yuan Chun , Chen Huijun 
Published: October 2016

PurposeTo determine whether pharmacokinetic modeling parameters with different output assumptions of dynamic contrast–enhanced MRI (DCE‐MRI) using Gd‐EOB‐DTPA correlate with serum‐based liver function tests, and compare the goodness of fit of the different output assumptions.MethodsA 6‐min DCE‐MRI protocol was performed in 38 patients. Four dual‐input two‐compartment models with different output assumptions and a published one‐compartment model were used to calculate hepatic function parameters. The Akaike information criterion fitting error was used to evaluate the goodness of fit. Imaging‐based hepatic function parameters were compared with blood chemistry using correlation with multiple comparison correction.ResultsThe dual‐input two‐compartment model assuming venous flow equals arterial flow plus portal venous flow and no bile duct output better described the liver tissue enhancement with low fitting error and high correlation with blood chemistry. The relative uptake rate
derived from this model was found to be significantly correlated with direct bilirubin (r = −0.52, P = 0.015), prealbumin concentration (r = 0.58, P = 0.015), and prothrombin time (r = −0.51, P = 0.026).ConclusionIt is feasible to evaluate hepatic function by proper output assumptions. The relative uptake rate has the potential to serve as a biomarker of function. Magn Reson Med 78:1488–1495, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Methotrexate hypersensitivity reactions in pediatrics: Evaluation and management
Authors: Dilley Meredith A. , Lee Joyce P. , Broyles Ana Dioun 
Published: October 2016

AbstractReports of hypersensitivity reactions (HSRs) to MTX are limited to single case studies. We retrospectively reviewed HSRs to MTX during a 12‐year period in our tertiary care pediatric center. Seven patients were evaluated for HSRs to MTX. Skin testing was positive in one of the four patients tested. One patient underwent successful graded challenge to MTX. Seventeen desensitizations to MTX were successfully performed in the other six patients. Skin testing, graded challenge, and desensitization were safe and effective procedures in the evaluation and management of patients with HSRs to MTX in our pediatric population.
If we can't have it, then no one should: Shutting Down Versus Selling in Family Business Portfolios
Authors: Akhter Naveed , Sieger Philipp , Chirico Francesco 
Published: October 2016

Research summaryHow does a business family manage its business portfolio in times of declining performance to sustain the portfolio's long‐term endurance? Drawing on social identity theory and six family business portfolios from Pakistan, we find that business families may prefer to shut down a satellite business rather than sell it, which is primarily driven by identity considerations. In addition, the family's goal to recycle the assets, the aim to restart the business later, and the increasing decline in performance are important contingency factors. This study contributes to the literature on portfolio entrepreneurship, business exit, and the enduring entrepreneurship of family firms.Managerial summaryFamily business managers and practitioners can benefit from our work, which provides evidence of how family firm portfolios can respond to business decline and ensure enduring entrepreneurship. Shutting down a satellite firm instead of selling it is a promising turnaround strategy that can prevent a family's identity loss while supporting the family business portfolio's continuity. Copyright © 2016 Strategic Management Society.
It isn't all just fun and games: Collegiate participation in extracurricular activities and risk for generalized and sexual harassment, psychological distress, and alcohol use
Authors: McGinley Meredith , Rospenda Kathleen M. , Liu Li , Richman Judith A. 
Published: October 2016

ABSTRACTCollegiate extracurricular activities, despite their benefits, may place students at an increased risk for experiencing harassment. This study utilizes multiple waves of data from an online longitudinal survey to examine how participation in college activities (intramural sports, fraternities/sororities, school clubs) relates to experiences of sexual and generalized harassment and outcomes (psychological distress, heavy alcohol use) among undergraduates (N = 1852, 58.6% female, 57.4% White) in the Midwestern United States. Activity participation was related to harassment, but the pattern depended on the activity, harassment type, and sex. Fraternity/sorority involvement was associated with generalized harassment, whereas school club involvement was linked to both generalized and sexual harassment. Female intramural athletes were at an increased risk to experience both harassment types. In addition to direct relations, activity participation was indirectly linked to future psychological distress (depression, anxiety) and heavy alcohol use via harassment. Implications for intervention with this college student population are discussed.
Anatomical dilatation of the superior vena cava associated with an arrhythmogenic response induced by SVC scan pacing after atrial fibrillation ablation
Authors: Imada Hiroshi , Fukuzawa Koji , Kiuchi Kunihiko , Matsumoto Akinori , Konishi Hiroki , Ichibori Hirotoshi , Hyogo Kiyohiro , Kurose Jun , Mori Shumpei , Takaya Tomofumi , Nishii Tatsuya , Kagawa Kiyosumi , Yoshida Akihiro , Ken‐ichi Hirata 
Published: October 2016

AbstractBackgroundThe relationship between pulmonary vein (PV) arrhythmogenicity and its anatomy has been reported. However, that of the superior vena cava (SVC) has not been well discussed. Arrhythmogenic response induced by pacing stimulation at SVC might help with identifying SVC arrhythmogenicity. The purpose of this study was to investigate the relationship between the anatomical dilatation of SVC and the arrhythmogenic response induced by pacing at SVC.MethodsForty‐three patients who underwent atrial fibrillation (AF) ablation were enrolled in this study. After PV isolation, scan pacing (up to triple extra stimulation following intrinsic sinus beats) was performed at SVC. The arrhythmogenic response was defined as following: (1) repetitive atrial responses, (2) non‐sustained, and (3) sustained AF/ atrial tachycardia. To assess the dilatation of SVC, we measured the cross‐sectional area of the SVC (SVC‐area) using multi‐planar reconstruction CT imaging.ResultsArrhythmogenic responses were documented in 24 patients (Group 1). No arrhythmogenic responses were documented in the remaining 19 patients (Group 2). The SVC‐area was significantly larger in Group 1 than Group 2 (3.1±0.9 vs. 2.2±0.8 cm2, P=0.004). A multivariate analysis revealed only SVC‐area was associated with arrhythmogenic responses (odds ratio=2.87, CI 1.05–7.82, P=0.04). Furthermore, AF recurrence rate was significantly higher in patients with SVC‐area>2.56 cm2 than those with SVC‐area <2.56 cm2 (9 [42.9%] of 21 vs. 3 [13.6%] of 22, P=0.026).ConclusionDilatation of SVC was associated with an arrhythmogenic response, and the AF recurrence rate was significantly higher in patients with large SVC‐area. Adjunctive catheter intervention for the SVC might be indicated in patients with a dilated SVC and an arrhythmogenic response.
Effect of expectation on pain assessment of lower- and higher-intensity stimuli
Authors: Ružić Valentina , Ivanec Dragutin , Stanke Koraljka Modić 
Published: October 2016

Abstract

Background and aims
Pain modulation via expectation is a well-documented phenomenon. So far it has been shown that expectations about effectiveness of a certain treatment enhance the effectiveness of different analgesics and of drug-free pain treatments. Also, studies demonstrate that people assess same-intensity stimuli differently, depending on the experimentally induced expectations regarding the characteristics of the stimuli. Prolonged effect of expectation on pain perception and possible symmetry in conditions of lower- and higher-intensity stimuli is yet to be studied. Aim of this study is to determine the effect of expectation on the perception of pain experimentally induced by the series of higher- and lower-intensity stimuli.

Methods
192 healthy participants were assigned to four experimental groups differing by expectations regarding the intensity of painful stimuli series. Expectations of two groups were congruent with actual stimuli; one group expected and received lower-intensity stimuli and the other expected and received higher-intensity stimuli. Expectations of the remaining two groups were not congruent with actual stimuli; one group expected higher-intensity stimuli, but actually received lower-intensity stimuli while the other group expected lower-intensity stimuli, but in fact received higher-intensity ones. Each group received a series of 24 varied-intensity electrical stimuli rated by the participants on a 30° intensity scale.

Results
Expectation manipulation had statistically significant effect on pain intensity assessment. When expecting lower-intensity stimuli, the participants underestimated pain intensity and when expecting higher-intensity stimuli, they overestimated pain intensity. The effect size of expectations upon pain intensity assessment was equal for both lower- and higher-intensity stimuli.

Conclusion
The obtained results imply that expectation manipulation can achieve the desired effect of decreasing or increasing both slight and more severe pain for a longer period of time. Manipulation via expectation before the stimuli series was proven to be effective for pain modulation in the entire series of stimuli which lasted around 10 min. The results suggest a potential benefit of manipulating expectations to alleviate emerging pain, since the obtained effects are moderate to large.

Implications
It seems that expectation effect is strong enough to “overcome” even the direct effect of stimulus intensity (at least in the low to moderate intensity range), which suggests potential benefits of verbal instructions even in rather painful stimuli.
Age-related variability in the presentation of symptoms of major depressive disorder
Authors: Schaakxs R. , Comijs H. C. , Lamers F. , Beekman A. T. F. , Penninx B. W. J. H. 
Published: October 2016

BackgroundThe heterogeneous aetiology of major depressive disorder (MDD) might affect the presentation of depressive symptoms across the lifespan. We examined to what extent a range of mood, cognitive, and somatic/vegetative depressive symptoms were differentially present depending on patient's age.MethodData came from 1404 participants with current MDD (aged 18–88 years) from two cohort studies: the Netherlands Study of Depression and Anxiety (NESDA) and the Netherlands Study of Depression in Older Persons (NESDO). Associations between age (per 10 years) and 30 depressive symptoms as well as three symptom clusters (mood, cognitive, somatic/vegetative) were assessed using logistic and linear regression analyses.ResultsDepression severity was found to be stable with increasing age. Nevertheless, 20 (67%) out of 30 symptoms were associated with age. Most clearly, with ageing there was more often early morning awakening [odds ratio (OR) 1.47, 95% confidence interval (CI) 1.36–1.60], reduced interest in sex (OR 1.42, 95% CI 1.31–1.53), and problems sleeping during the night (OR 1.33, 95% CI 1.24–1.43), whereas symptoms most strongly associated with younger age were interpersonal sensitivity (OR 0.72, 95% CI 0.66–0.79), feeling irritable (OR 0.73, 95% CI 0.67–0.79), and sleeping too much (OR 0.75, 95% CI 0.68–0.83). The sum score of somatic/vegetative symptoms was associated with older age (B = 0.23, p < 0.001), whereas the mood and cognitive sum scores were associated with younger age (B = −0.20, p < 0.001; B = −0.04, p = 0.004).ConclusionsDepression severity was found to be stable across the lifespan, yet depressive symptoms tend to shift with age from being predominantly mood-related to being more somatic/vegetative. Due to the increasing somatic presentation of depression with age, diagnoses may be missed.
Modeling of Infrared–Visible Sum Frequency Generation Microscopy Images of a Giant Liposome
Authors: Volkov Victor , Perry Carole C. 
Published: October 2016

AbstractThe article explores the theory of infrared–visible sum frequency generation microscopy of phospholipid envelopes with dimensions larger than the wavelength of the nonlinear emission. The main part of the study concerns derivation and accounting for the contributions of effective nonlinear responses specific to sites on the surfaces of a bilayer envelope and their dependence on polarization condition and experimental geometry. The nonlinear responses of sites are mapped onto the image plane according to their emission directions and the numerical aperture of a sampling microscope objective. According to the simulation results, we discuss possible approaches to characterize the shape of the envelope, to extract molecular hyperpolarizabilities, and to anticipate possible heterogeneity in envelope composition and anisotropy of the environment proximal to the envelope. The modeling approach offers a promising analytic facility to assist connecting microscopy observations in engineered liposomes, cellular envelopes, and subcellular organelles of relatively large dimensions to molecular properties, and hence to chemistry and structure down to available spatial resolution.
Why Do We Need to Use Three-Dimensional (3D) Fourier Transform (FT) Analysis to Evaluate a High-Performance Transmission Electron Microscope (TEM)?
Authors: Ishizuka Kazuo , Kimoto Koji 
Published: October 2016

AbstractThe resolution of high-resolution transmission electron microscopes (TEM) has been improved down to subangstrom levels by correcting the spherical aberration (Cs) of the objective lens, and the information limit is thus determined mainly by partial temporal coherence. As a traditional Young’s fringe test does not reveal the true information limit for an ultra-high-resolution electron microscope, new methods to evaluate temporal coherence have been proposed based on a tilted-beam diffractogram. However, the diffractogram analysis cannot be applied when the nonlinear contribution becomes significant. Therefore, we have proposed a method based on the three-dimensional (3D) Fourier transform (FT) of through-focus TEM images, and evaluated the performance of someCs-corrected TEMs at lower voltages. In this report, we generalize the 3D FT analysis and derive the 3D transmission cross-coefficient. The profound difference of the 3D FT analysis from the diffractogram analysis is its capability to extract linear image information from the image intensity, and further to evaluate two linear image contributions separately on the Ewald sphere envelopes. Therefore, contrary to the diffractogram analysis the 3D FT analysis can work with a strong scattering object. This is the necessary condition if we want to directly observe the linear image transfer down to a few tens of picometer.
Search for Close-in Planets around Evolved Stars with Phase-curve variations and Radial Velocity Measurements
Authors: Hirano Teruyuki , Sato Bun'ei , Masuda Kento , Benomar Othman Michel , Takeda Yoichi , Omiya Masashi , Harakawa Hiroki 
Published: October 2016

AbstractTidal interactions are a key process to understand the evolution history of close-in exoplanets. But tidals still have a large uncertainty in their prediction for the damping timescales of stellar obliquity and semi-major axis. We have worked on a search for transiting giant planets around evolved stars, for which few close-in planets were discovered. It has been reported that evolved stars lack close-in planets, which is often attributed to the tidal evolution and/or engulfment of close-in planets by the hosts. Meanwhile, Kepler has detected a certain fraction of transiting planet candidates around evolved stars. Confirming the planetary nature for these candidates is especially important since the comparison between the occurrence rates of close-in planets around main sequence stars and evolved stars provides a unique opportunity to discuss the final stage of close-in planets. With the aim of confirming KOI planet candidates around evolved stars, we measured precision radial velocities (RVs) for evolved stars with transiting planet candidates using Subaru/HDS. We also developed a new code which simultaneously models and fits the observed RVs and phase-curve variations in the Kepler data (e.g., transits, stellar ellipsoidal variations, and planet emission/reflected light). As a result of applying the global fit to KOI giants/subgiants, we confirmed two giant planets around evolved stars (Kepler-91 and KOI-1894), as well as revealed that KOI-977 is more likely a false positive.
Nā Inoa Hōkū: Hawaiian and Polynesian star names
Authors: Ruggles Clive , Johnson Rubellite Kawena , Mahelona John Kaipo 
Published: October 2016

AbstractIn this paper we report on a 15-year project to construct a comprehensive catalogue of Hawaiian starnames documented in historical sources, published during the IAU General Assembly. Hawaiian star knowledge represents incomparable intangible heritage relating to Polynesian navigation in the Pacific. It both informs and motivates living cultural traditions aiming to reconstruct and build upon such knowledge.
Astronomy in the City for Astronomy Education
Authors: Ros Rosa M. , Garc Beatriz 
Published: October 2016

AbstractAstronomy is part of our culture. Astronomy cannot be isolated in a classroom, it has to be integrated in the normal life of teachers and students. “Astronomy in the city” is an important part of NASE (Network for Astronomy School Education) (Ros & Hemenway 2012). In each NASE course we introduce a “working group session” chaired by a local expert in cultural astronomy. The chair introduces several examples of astronomy in their city and after that, the participants have the opportunity to discuss and mention several similar examples. After this session all participants visit one or two sites proposed and introduced by the chair.After more than 5 years using this method we visited and discovered several examples of astronomy in the city:•Astronomy in ancient typical clothes.•Archaeological temples oriented according to the sunrise or set.•Petroglyphs with astronomical meaning.•Astronomy in monuments.•Sundials.•Oriented Colonial churches.•Astronomy in Souvenirs.In any case, teachers and students discover that Astronomy is part of their everyday life. They can take into account the Sun's path when they park their car or when they take a bus “what is the best part in order to be seat in the shadow during the journey?” The result is motivation to go with “open eyes” when they are in the street and they try to get more and more information about their surroundings.In summary, one of the main activities is to introduce local cultural aspects in NASE astronomy courses. The participants can discover a new approach to local culture from an astronomical point of view.
The data sharing advantage in astrophysics
Authors: Dorch Bertil F. , Drachen Thea M. , Ellegaard Ole 
Published: October 2016

AbstractWe present here evidence for the existence of a citation advantage within astrophysics for papers that link to data. Using simple measures based on publication data from NASA Astrophysics Data System we find a citation advantage for papers with links to data receiving on the average significantly more citations per paper than papers without links to data. Furthermore, using INSPEC and Web of Science databases we investigate whether either papers of an experimental or theoretical nature display different citation behavior.
That over-used and much abused 4-letter word: DATA
Authors: Griffin Elizabeth 
Published: October 2016

AbstractIn its prime state, DATA is a Latin word meaning “[things] given”, a plural noun derived from the verb “To Give”. Its singular form is DATUM. Modern conversation equates DATA with “Information”, while modern philosophies on information management are getting entwined with parallel philosophies on knowledge management. In some ways that is a positive development, and is greatly assisted by Open Access and Internet policies, but in others it is more detrimental, by threatening to blur the essential distinction between objectivity and subjectivity in our science. We examine that essential distinction from the view-points of observers, authors (and publishers), and database managers, and suggest where, when and how the distinctiveness of their fundamental contributions to the communication and validation of research results should be respected and upheld.
Validation of transting planet candidates: a Bayesian view
Authors: Díaz Rodrigo F. , Almenara Jose Manuel , Santerne Alexandre 
Published: October 2016

AbstractTransiting candidate validation is essentially a Bayesian model comparison problem: different models, all explaining the observations comparably well, compete for the support of the available data. The basic characteristics of the planet validation problem are discussed and the different approaches taken to tackle its difficulties are reviewed.