bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life in Pediatric Patients with Allergic Rhinitis treated at the Medical Clinic of Integrated Education – Unisul
Authors: Dziekanski Mariana , Marcelino Taíse 
Published: March 2017

Introduction Allergic rhinitis is a common disease among children and adolescents, reaching up to 40% of the population. During childhood, it is usually underdiagnosed because it has nonspecific symptoms. It has a negative impact on quality of life and may predispose to comorbidities. The diagnosis is clinical and treatment aims prevention.
Objective The objective of this study is to evaluate the quality of life in pediatric patients with allergic rhinitis.
Methods This is an observational study with cross-sectional design. The population consisted of pediatric patients with allergic rhinitis treated at the Medical Clinic of Integrated Education (MCIE) – Universidade do Sul de Santa Catarina - Unisul, Tubarão, SC, Brazil. We collected data from March to June 2016 through the application of the Sociodemographic and Health Questionnaire, rhinitis module of the International Study of Asthma and Allergies in Childhood Questionnaire and the Rhinoconjunctivitis Quality of Life Questionnaire Modified.
Results Out of the 69 respondents, 52.2% were boys with a mean age of 10.13 years old. The predominant education level of parents/guardians was incomplete second grade and average income level was two minimum wages. 81.2% said they had previous treatment for AR, 30.4% had asthma and 7.2% eczema. Incidence of patients smoking was absent and family (parents/guardians) smoking was 17.4%. March to July were the months of highest symptom occurrence, slightly disturbing daily activities. The mean value of severity was 51.9, nasal symptoms were the most uncomfortable, and nasal itchiness was the most cited.
Conclusion Our results highlight that allergic symptoms negatively impact the life of people with allergic rhinitis, with a predominance of nasal symptoms, especially nasal itchy, representing a poor quality of life of the interviewed.
Salivary Iron (Fe) Ion Levels, Serum Markers of Anemia and Caries Activity in Pregnant Women
Authors: Azevedo Juliana Aires Paiva de , Martins Rafiza Félix Marão , Rodrigues Vandilson Pereira , Alves Cláudia Maria Coêlho , Ribeiro Cecília Cláudia Costa , Thomaz Erika Bárbara Abreu Fonseca , Costa Elisa Miranda 
Published: March 2017

Introduction Anemia is a very frequent event among pregnant women. There are evidences of differences in the incidence of dental caries between pregnant and non-pregnant women, but the relationship between salivary iron (Fe) and serum markers of anemia and caries development has not been investigated.
Objective To evaluate the correlation between salivary (Fe) and serum iron (Fe, ferritin and hemoglobin) parameters in pregnant women with the development of dental caries.
Methods A prospective cohort was conducted with 59 women. The outcome of interest was represented by new dental caries lesions during pregnancy, using the Nyvad criteria. Pregnant women were evaluated at three clinical times: up to the 16th week of gestational age (GA) (T1), in the last trimester of pregnancy (T2), and postpartum (T3), at the Mother and Child Unit of University Hospital of the Universidade Federal do Maranhão. A stimulated saliva sample was collected for biochemical analysis of salivary Fe, and a blood sample was collected early in the morning. The correlation between salivary and serum Fe was evaluated through the Pearson correlation test. Analysis of variance (ANOVA) and Kruskal-Wallis were used to compare the means of anemia parameters at different times. The Student's t and Mann-Whitney tests were used to compare the anemia parameters between the groups of pregnant women (with and without new caries lesions).
Results Serum Fe concentrations were higher in the first trimester of pregnancy and lower after delivery (p = 0.036). It was also observed that the ferritin concentrations were higher in the first trimester and lower at the end of gestation (p = 0.011). There was no association between the expositions of salivary iron and anemia, and the development of dental caries. There was a positive correlation between serum Fe in T1 and salivary Fe in T2 (p < 0.05).
Conclusion The serum markers of anemia were more prevalent in the last trimester of pregnancy.
Andermann Syndrome in a Pakistani Family Caused by a Novel Mutation in SLC12A6
Authors: Muñoz Tatiana , Krishnan Pradeep , Vajsar Jiri , Laughlin Suzanne , Yoon Grace 
Published: March 2017

AbstractAgenesis of the corpus callosum with peripheral neuropathy (ACCPN) or Andermann syndrome is an autosomal recessive condition caused by mutations in SLC12A6. The neurodegenerative features are characterized primarily by severe and progressive polyneuropathy, with eventual loss of ambulation and limited lifespan. We report two siblings with Andermann syndrome from a consanguineous Pakistani family with severe global developmental delays, sensory-motor polyneuropathy, and complete agenesis of the corpus callosum, associated with a homozygous c.745+2T>A mutation in SLC12A6. This sequence change is predicted to inactivate the donor splice site and abolish correct splicing of intron 6, yielding an abnormally truncated protein. This is the first report of Andermann syndrome in patients of Pakistani origin, which supports the pan-ethnic incidence of this condition.
A Previously Unreported Arterial Variant of the Suboccipital Region Based on Cadaveric Dissection
Authors: Fisahn Christian , Burgess Brittni , Iwanaga Joe , Alonso Fernando , Chapman Jens , Oskouian Rod , Tubbs R. 
Published: March 2017

Introduction Several arterial variants have been reported to occur around the posterior arch of the atlas. Understanding the various anomalies and diagnosing them preoperatively can dramatically reduce the risk of surgical insult during neurosurgical procedures. Herein we report a case of an arterial variant found just below the posterior arch of C1.
Case Report During the routine dissection of the suboccipital region via a posterior approach, an unusual bulge was identified just inferior to the inferior capitis oblique muscle. With further dissection, the structure was identified as a tortuous internal carotid artery.
Conclusion Arterial variants around the posterior arch of C1 are surgically significant and can result in catastrophic injuries if unappreciated. Most of these variants will be related to the vertebral artery. To our knowledge, an arterial variant of the internal carotid artery in this location, as reported herein, has not been previously reported.
Modified Lung Ultrasound Score for Assessing and Monitoring Pulmonary Aeration
Authors: Mongodi Silvia , Bouhemad Bélaïd , Orlando Anita , Stella Andrea , Tavazzi Guido , Via Gabriele , Iotti Giorgio , Braschi Antonio , Mojoli Francesco 
Published: March 2017

Abstract
Purpose Lung Ultrasound Score (LUSS) is a useful tool for lung aeration assessment but presents two theoretical limitations. First, standard LUSS is based on longitudinal scan and detection of number/coalescence of B lines. In the longitudinal scan pleura visualization is limited by intercostal space width. Moreover, coalescence of B lines to define severe loss of aeration is not suitable for non-homogeneous lung pathologies where focal coalescence is possible. We therefore compared longitudinal vs. transversal scan and also cLUSS (standard coalescence-based LUSS) vs. qLUSS (quantitative LUSS based on % of involved pleura).
Materials and methods 38 ICU patients were examined in 12 thoracic areas in longitudinal and transversal scan. B lines (number, coalescence), subpleural consolidations (SP), pleural length and pleural involvement (> or ≤ 50 %) were assessed. cLUSS and qLUSS were computed in longitudinal and transversal scan.
Results Transversal scan visualized wider (3.9 [IQR 3.8 – 3.9] vs 2.0 [1.6 – 2.5] cm, p < 0.0001) and more constant (variance 0.02 vs 0.34 cm, p < 0.0001) pleural length, more B lines (70 vs 59 % of scans, p < 0.0001), coalescence (39 vs 28 %, p < 0.0001) and SP (22 vs 14 %, p < 0.0001) compared to longitudinal scan. Pleural involvement > 50 % was observed in 17 % and coalescence in 33 % of cases. Focal coalescence accounted for 52 % of cases of coalescence. qLUSS-transv generated a different distribution of aeration scores compared to cLUSS-long (p < 0.0001).
Conclusion In unselected ICU patients, variability of pleural length in longitudinal scans is high and focal coalescence is frequent. Transversal scan and quantification of pleural involvement are simple measures to overcome these limitations of LUSS.
The Validation of a Paddle Power Meter for Slalom Kayaking
Authors: Macdermid Paul , Fink Philip 
Published: March 2017

AbstractThe ability to quantify power within the sport of slalom kayaking would provide coaches and athletes objective data to monitor performance. This study determined the validity of a kayak paddle power meter and subsequent relationship between work rate and stroke kinetics. One participant completed multiple trials of a flat-water, straight-line sprint and a sequence of slalom gates at numerous intensities to attain the velocity:power relationship. Laboratory results identified the kayak paddles’ strain gauges were valid and reliable, and field tests presented a cubic relationship for power as a function of velocity in the straight-line sprint (R2=0.982) and the slalom-specific test (R2=0.993). Further analysis of stroke kinetics identified velocity of hand movement at individual peak force capability to be critical in the highest work rates achieved for both slalom and flat-water sprinting. It was concluded that the kayak paddle power meter tested is a valid means of recording work rate and stroke kinetics during kayaking in the field.
The elderly liver transplant recipients: anxiety, depression, fatigue and life satisfaction
Authors: Krenzien Felix , Krezdorn Nicco , Morgül Mehmet , Wiltberger Georg , Atanasov Georgi , Hau Hans-Michael , Hinz Andreas , Schmelzle Moritz , Bartels Michael , Benzing Christian 
Published: March 2017

Abstract
Introduction Older patients are neglected in clinical trials and are likely to be excluded from liver transplantation (LT). The aim of this study was to assess fatigue, anxiety, depression, and health-related quality of life (HRQoL) in elderly LT recipients.
Methods Questionnaires were mailed to patients who underwent LT between 1993 and 2013. Three groups were created: patients ≥ 70, 60 – 69, and < 60 years old. Mental-health status, life satisfaction, and fatigue were assessed using, respectively, the Hospital Anxiety and Depression Scale (HADS), Questions on Life Satisfaction (FLZ-M), and the Multidimensional Fatigue Inventory (MFI-20).
Results In total, 276 eligible questionnaires (40.1 %) were received out of 689 patients with a history of LT. No age-related differences were found with regard to anxiety or depression in the study sample. Patients ≥ 70 years old had significantly better life satisfaction in regards to income (p = 0.003) and work (p = 0.005) compared to patients < 60 years. The overall fatigue scores were the highest in patients < 60 years (52.7, SD = 15.8) and ≥ 70 years (52.7, SD = 17.7) compared to patients 60 – 69 years old (48.2, SD = 17.3, p = 0.037).
Discussion Advanced age alone should not be considered a contraindication for LT due to potentially poor quality of life outcomes.
Femoral Neck Stress Fractures in Sport: A Current Concepts Review
Authors: Robertson Greg , Wood Alexander 
Published: March 2017

AbstractFemoral neck stress fractures (FNSFs) account for 3% of all sport-related stress fractures. The commonest causative sports are marathon and long-distance running.The main types of FNSF are compression-sided, tension-sided and displaced. The most common reported symptom is exercise-related groin pain. Radiographs form the first line of investigation, with MRI the second-line investigation.The management of FNSFs is guided by the location and displacement of the fracture. Delay in diagnosis is common and increases the likelihood of fracture displacement. Sporting outcomes are considerably worse for displaced fractures. Education programmes and treatment protocols can reduce the rates of displaced FNSFs.This article aims to provide a current concepts review on the topic of FNSFs in sport, assess the current evidence on the epidemiology and pathophysiology of these injuries, detail the current recommendations for their imaging and management, and review the recorded sporting outcomes for FNSFs in the existing literature.From this study, we conclude that although FNSFs are a rare injury, they should be considered in all athletes presenting with exercise-related hip pain, because delay in diagnosis and subsequent fracture displacement can significantly impair future return to sport. However, when detected early, FNSFs show promising results in terms of return-to-sport rates and times.
Tagging SNP-set selection with maximum information based on linkage disequilibrium structure in genome-wide association studies
Authors: Wang Shudong , He Sicheng , Yuan Fayou , Zhu Xinjie 
Published: March 2017

Abstract

Motivation
Effective tagging single-nucleotide polymorphism (SNP)-set selection is crucial to SNP-set analysis in genome-wide association studies (GWAS). Most of the existing tagging SNP-set selection methods cannot make full use of the information hidden in common or rare variants associated diseases. It is noticed that some SNPs have overlapping genetic information owing to linkage disequilibrium (LD) structure between SNPs. Therefore, when testing the association between SNPs and disease susceptibility, it is sufficient to elect the representative SNPs (called tag SNP-set or tagSNP-set) with maximum information.

Results
It is proposed a new tagSNP-set selection method based on LD information between SNPs, namely TagSNP-Set with Maximum Information. Compared with classical SNP-set analytical method, our method not only has higher power, but also can minimize the number of selected tagSNPs and maximize the information provided by selected tagSNPs with less genotyping cost and lower time complexity.

Supplementary information
Supplementary data are available at Bioinformatics online.
Spatial and temporal changes in pot-fishing effort and habitat use
Authors: Stephenson Fabrice , Polunin Nicholas V. C. , Mill Aileen C. , Scott Catherine , Lightfoot Paula , Fitzsimmons Clare 
Published: March 2017

AbstractHabitat and fisheries usage data are key components for ecosystem-based approach to fisheries management (EBFM). Significant gaps in knowledge remain for fisheries–habitat interactions, particularly in inshore fisheries where vessels are &lt;12 m in length. Here, we show changes in inshore fishing effort distribution (&lt;12 m) and habitat use over the decade 2004–2013. Sightings data of fishing vessel activity recorded by the Northumberland Inshore Fishery and Conservation Authority (NIFCA) were combined with landings data to estimate and map pot-fishing activity between 2004 and 2013. Spatial temporal changes were investigated using Monte Carlo simulation of randomly sampled fishing effort maps. High resolution (1 m) broadscale (EUNIS level 3) predictive habitat maps of the Coquet to St Marys’ Marine Conservation Zone (CQSM MCZ) were used to investigate spatial temporal changes in fishers’ habitat selection using compositional analysis. Fishing effort in Northumberland increased between 2004 and 2013 (233 642–354 193 pots year−1). Fishing effort distribution differed between individual years, decreasing over large areas between 2004 and 2007, followed by increases, especially inshore, between 2008 and 2013. Fishers in the CQSM MCZ showed a preference for rocky habitats over sediment habitats. Habitat preference did not vary between years although all habitats experienced increasing fishing pressure. Spatial temporal changes in fishing effort and habitat use were discussed in relation to EBFM.
Properties of Local Group galaxies in hydrodynamical simulations of sterile neutrino dark matter cosmologies
Authors: Lovell Mark R. , Bose Sownak , Boyarsky Alexey , Crain Robert A. , Frenk Carlos S. , Hellwing Wojciech A. , Ludlow Aaron D. , Navarro Julio F. , Ruchayskiy Oleg , Sawala Till , Schaller Matthieu , Schaye Joop , Theuns Tom 
Published: March 2017

AbstractWe study galaxy formation in sterile neutrino dark matter models that differ significantly from both cold and from ‘warm thermal relic’ models. We use the eagle code to carry out hydrodynamic simulations of the evolution of pairs of galaxies chosen to resemble the Local Group, as part of the APOSTLE simulations project. We compare cold dark matter (CDM) with two sterile neutrino models with 7 keV mass: one, the warmest among all models of this mass (LA120) and the other, a relatively cold case (LA10). We show that the lower concentration of sterile neutrino subhaloes compared to their CDM counterparts makes the inferred inner dark matter content of galaxies like Fornax (or Magellanic Clouds) less of an outlier in the sterile neutrino cosmologies. In terms of the galaxy number counts, the LA10 simulations are indistinguishable from CDM when one takes into account halo-to-halo (or ‘simulation-to-simulation’) scatter. In order for the LA120 model to match the number of Local Group dwarf galaxies, a higher fraction of low-mass haloes is required to form galaxies than is predicted by the eagle simulations. As the census of the Local Group galaxies nears completion, this population may provide a strong discriminant between cold and warm dark matter models.
Gravitational collapse to a Kerr–Newman black hole
Authors: Nathanail Antonios , Most Elias R. , Rezzolla Luciano 
Published: March 2017

Abstract
We present the first systematic study of the gravitational collapse of rotating and magnetized neutron stars to charged and rotating (Kerr–Newman) black holes. In particular, we consider the collapse of magnetized and rotating neutron stars assuming that no pair-creation takes place and that the charge density in the magnetosphere is so low that the stellar exterior can be described as an electrovacuum. Under these assumptions, which are rather reasonable for a pulsar that has crossed the ‘death line’, we show that when the star is rotating, it acquires a net initial electrical charge, which is then trapped inside the apparent horizon of the newly formed back hole. We analyse a number of different quantities to validate that the black hole produced is indeed a Kerr–Newman one and show that, in the absence of rotation or magnetic field, the end result of the collapse is a Schwarzschild or Kerr black hole, respectively.
Canadian values, social policy and the health of our kids
Authors: Denburg Avram 
Published: March 2017

AbstractWhat explains the widening disparities in child health and social circumstance in Canada? And why do we tolerate such inequality? In the present commentary, the author argues that to understand – and ultimately influence – the trajectory of child health and well-being in our country, we must attend to the impact of social policy on the life chances of Canadian children. This, in turn, demands that we probe the fundamental values that guide social policy in modern welfare states and locate Canada's place in this political spectrum. The author explores the controversial tax policy of income-splitting to contextualize this discussion of values, and argues that our polity increasingly privileges economic liberty above equality or solidarity. Until those best positioned to advocate for children – including paediatricians and child health care providers – begin to engage with social policy, the health and well-being of Canada's children will remain a tale of two increasingly different worlds.
Physical Activity Self-Management and Coaching Compared to Social Interaction in Huntington Disease: Results From the ENGAGE-HD Randomized, Controlled Pilot Feasibility Trial
Authors: Busse Monica , Quinn Lori , Drew Cheney , Kelson Mark , Trubey Rob , McEwan Kirsten , Jones Carys , Townson Julia , Dawes Helen , Tudor-Edwards Rhiannon , Rosser Anne , Hood Kerenza 
Published: March 2017

Abstract
Background. Self-management and self-efficacy for physical activity is not routinely considered in neurologic rehabilitation.
Objective. This study assessed feasibility and outcomes of a 14-week physical activity self-management and coaching intervention compared with social contact in Huntington disease (HD) to inform the design of a future full-scale trial.
Design. Assessor blind, multisite, randomized pilot feasibility trial.
Setting. Participants were recruited and assessed at baseline, 16 weeks following randomization, and then again at 26 weeks in HD specialist clinics with intervention delivery by trained coaches in the participants’ homes.
Patients and Intervention. People with HD were allocated to the ENGAGE-HD physical activity coaching intervention or a social interaction intervention.
Measurements. Eligibility, recruitment, retention, and intervention participation were determined at 16 weeks. Other outcomes of interest included measures of mobility, self-efficacy, physical activity, and disease-specific measures of motor and cognition. Fidelity and costs for both the physical activity and social comparator interventions were established.
Results. Forty percent (n = 46) of eligible patients were enrolled; 22 were randomized to the physical intervention and 24 to social intervention. Retention rates in the physical intervention and social intervention were 77% and 92%, respectively. Minimum participation criteria were achieved by 82% of participants in the physical intervention and 100% in the social intervention. There was no indication of between-group treatment effects on function; however, increases in self-efficacy for exercise and self-reported levels of physical activity in the physical intervention lend support to our predefined intervention logic model.
Limitations. The use of self-report measures may have introduced bias.
Conclusions. An HD physical activity self-management and coaching intervention is feasible and worthy of further investigation.
The Predictive Validity of a Text-Based Situational Judgment Test in Undergraduate Medical and Dental School Admissions
Authors: Patterson Fiona , Cousans Fran , Edwards Helena , Rosselli Anna , Nicholson Sandra , Wright Barry 
Published: March 2017

Problem
Situational judgment tests (SJTs) can be used to assess the nonacademic attributes necessary for medical and dental trainees to become successful practitioners. Evidence for SJTs’ predictive validity, however, relates predominantly to selection in postgraduate settings or using video-based SJTs at the undergraduate level; it may not be directly transferable to text-based SJTs in undergraduate medical and dental school selection. This preliminary study aimed to address these gaps by assessing the validity of the UK Clinical Aptitude Test (UKCAT) text-based SJT.

Approach
Study participants were 218 first-year medical and dental students from four UK undergraduate schools who completed the first UKCAT text-based SJT in 2013. Outcome measures were educational supervisor ratings of in-role performance in problem-based learning tutorial sessions—mean rating across the three domains measured by the SJT (integrity, perspective taking, and team involvement) and an overall judgment of performance—collected in 2015.

Outcomes
There were significant correlations between SJT scores and both mean supervisor ratings (uncorrected r = 0.24, P < .001; corrected r = 0.34) and overall judgments (uncorrected r

s
= 0.16, P < .05; corrected r

s
= 0.20). SJT scores predicted 6% of variance in mean supervisor ratings across the three nonacademic domains.

Next Steps
The results provide evidence that a well-designed text-based SJT can be appropriately integrated, and add value to, the selection process for undergraduate medical and dental school. More evidence is needed regarding the longitudinal predictive validity of SJTs throughout medical and dental training pathways, with appropriate outcome criteria.