bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Analysis of Grain Yield Stability and Environmental Interactions in a Multiparental Soybean Population
Authors: Xavier Alencar , Jarquin Diego , Howard Reka , Ramasubramanian Vishnu , Specht James E , Graef George L , Beavis William D , Diers Brian W , Song Qijian , Cregan Perry B , Nelson Randall , Mian Rouf , Shannon J Grover , McHale Leah , Wang Dechun , Schapaugh William , Lorenz Aaron J , Xu Shizhong , Muir William M , Rainey Katy M 
Published: December 2017

AbstractGenetic improvement toward optimized and stable agronomic performance of soybean genotypes is desirable for food security. Understanding how genotypes perform in different environmental conditions helps breeders develop sustainable cultivars adapted to target regions. Complex traits of importance are known to be controlled by a large number of genomic regions with small effects whose magnitude and direction are modulated by environmental factors. Knowledge of the constraints and undesirable effects resulting from genotype by environmental interactions is a key objective in improving selection procedures in soybean breeding programs. In this study, the genetic basis of soybean grain yield responsiveness to environmental factors was examined in a large soybean nested association population. For this, a genome-wide association to performance stability estimates generated from a Finlay-Wilkinson analysis and the inclusion of the interaction between marker genotypes and environmental factors was implemented. Genomic footprints were investigated by analysis and meta-analysis using a recently published multiparent model. Results indicated that specific soybean genomic regions were associated with stability, and that multiplicative interactions were present between environments and genetic background. Seven genomic regions in six chromosomes were identified as being associated with genotype-by-environment interactions. This study provides insight into genomic assisted breeding aimed at achieving a more stable agronomic performance of soybean, and documented opportunities to exploit genomic regions that were specifically associated with interactions involving environments and subpopulations.
Streitverkündung und sekundäre Darlegungslast seit der 9. GWB-Novelle – was bleibt vom ORWI-Urteil des BGH?
Authors: Thole Christoph 
Published: December 2017

Zusammenfassung
Im ORWI-Urteil von 2011 hatte der BGH die Streitverkündung als taugliches Instrument zur Prozesskoordination bei Kartellschadensersatzklagen hervorgehoben. Die Streitverkündung ermögliche es dem Kartellanten, eine Mehrfachhaftung auf verschiedenen Vertriebsstufen zu vermeiden. Daher bedürfe es weiterreichender Darlegungslasten des unmittelbaren Abnehmers zum passing on des Preisaufschlags nicht. Mit der 9. GWB-Novelle hat der Gesetzgeber das Kartellschadensersatzrecht auf eine neue Grundlage gestellt. Der Beitrag geht der Frage nach, ob und inwieweit die Ansätze des BGH seit der Novelle noch Bestand haben können.
Big Data and Competition Law
Authors: Tamke Maren 
Published: December 2017

Abstract
The emergence of Big Data in the digital economy and its corresponding impact on competition law has led to considerable debate in Europe over the last few years. A key concern for competition agencies is the potential harm that might be caused by a company’s ability to acquire datasets that other industry players cannot replicate. It is feared that the control of data may enable these firms to strengthen their market positions and to engage in anticompetitive behaviour, which could deprive consumers of the potential benefits that Big Data offers. Specifically, dominant companies might use Big Data to limit competition or to exploit consumers. In addition, tacit or explicit collusion amongst competitors could be facilitated by greater market transparency and the increasing application of algorithms. In future data-related transactions the potential aggregation of large datasets might also lead to greater scrutiny on the impacts of Big Data and the potential it might have to erect barriers to entry in the specific market and prevent viable competition. As such, regulators and policy makers are contemplating new approaches to ensure that data-related transactions that could significantly impede effective competition do not escape merger control scrutiny. This article considers these potential impacts of Big Data in competition law and outlines the key issues that might need to be addressed.
Cerebral Palsy in Extremely Preterm Infants
Authors: Hafström Maria , Källén Karin , Serenius Fredrik , Maršál Karel , Rehn Eva , Drake Helen , Ådén Ulrika , Farooqi Aijaz , Thorngren-Jerneck Kristina , Strömberg Bo 
Published: December 2017

BACKGROUND AND OBJECTIVES:The risk of cerebral palsy (CP) is high in preterm infants and is often accompanied by additional neurodevelopmental comorbidities. The present study describes lifetime prevalence of CP in a population-based prospective cohort of children born extremely preterm, including the type and severity of CP and other comorbidities (ie, developmental delay and/or cognitive impairment, neurobehavioral morbidity, epilepsy, vision and hearing impairments), and overall severity of disability. In this study, we also evaluate whether age at assessment, overall severity of disability, and available sources of information influence outcome results.METHODS:All Swedish children born before 27 weeks’ gestation from 2004 to 2007 were included (the Extremely Preterm Infants in Sweden Study). The combination of neonatal information, information from clinical examinations and neuropsychological assessments at 2.5 and 6.5 years of age, original medical chart reviews, and extended chart reviews was used.RESULTS:The outcome was identified in 467 (94.5%) of eligible children alive at 1 year of age. Forty-nine (10.5%) children had a lifetime diagnosis of CP, and 37 (76%) were ambulatory. Fourteen (29%) had CP diagnosed after 2.5 years of age, 37 (76%) had at least 1 additional comorbidity, and 27 (55%) had severe disability. The probability for an incomplete evaluation was higher in children with CP compared with children without CP.CONCLUSIONS:Children born extremely preterm with CP have various comorbidities and often overall severe disability. The importance of long-term follow-up and of obtaining comprehensive outcome information from several sources in children with disabilities is shown.
Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases
Authors: Albany Costantine , Einhorn Lawrence , Garbo Lawrence , Boyd Thomas , Josephson Neil , Feldman Darren R. 
Published: December 2017

AbstractBackgroundCytotoxic therapy for relapsed and refractory germ cell tumors or metastatic sex cord stromal tumors is rarely effective and is often accompanied by high adverse event rates. Expression of CD30 has been observed in testicular cancers, and patients with CD30-expressing embryonal carcinomas have worse progression-free survival and overall survival than those with CD30-negative tumors. The objective of this study (NCT01461538) was to characterize the antitumor activity of brentuximab vedotin in patients with CD30-expressing nonlymphomatous malignancies. Enrolled patients included seven patients with relapsed or refractory germ cell tumors or metastatic sex cord stromal tumors described in this case series.Materials and MethodsForty patients with relapsed or refractory germ cell tumors, metastatic sex cord stromal tumors, or testicular tumors were screened for CD30 expression; 14 patients had tumors that expressed CD30. Seven patients with CD30-expressing testicular cancer were enrolled in the treatment study: five patients with germ cell tumors, one patient with a Leydig cell tumor, and one patient with a Sertoli cell tumor. Patients were treated with brentuximab vedotin at initial doses of 1.8 or 2.4 mg/kg every 3 weeks. Response assessments were performed at cycles 2 and 4 and every 4 cycles thereafter while the patient was receiving treatment.ResultsTwo of seven patients achieved an objective response, including one durable complete response and one partial response at a single time point. Both responding patients had germ cell tumors. Treatment with brentuximab vedotin was generally well tolerated.ConclusionTreatment of relapsed or refractory germ cell tumors with brentuximab vedotin can induce durable responses with a manageable toxicity profile.Implications for PracticeThis case series of seven patients with relapsed or refractory CD30-expressing germ cell tumors (GCTs) or sex cord stromal tumors demonstrates that brentuximab vedotin has activity against GCTs and is well tolerated in heavily pretreated patients with these aggressive tumor types. One patient achieved a complete response that has been durable for almost 4 years since the discontinuation of treatment with brentuximab vedotin. Therefore, brentuximab vedotin may be a valuable option for physicians who care for this difficult-to-treat patient population.
CLARICE LISPECTOR TRADUZIDA E TRADUTORA: ESTADO DA ARTE
Authors: Hanes Vanessa Lopes Lourenço , Guerini Andréia 
Published: December 2017

O objetivo deste artigo é apresentar um panorama de estudos sobre a obra de Clarice Lispector traduzida no exterior, bem como sobre sua atuação como tradutora literária no contexto nacional, destacando as mais representativas abordagens em âmbito acadêmico nacional até o momento. Os resultados encontrados apontam para tendências associando Clarice Lispector e os Estudos da Tradução e indicam lacunas a serem supridas por possíveis pesquisas futuras. This work is licensed under a Creative Commons Attribution 3.0 License.
AS DIMENSÕES DO AGIR DOCENTE NO TRABALHO COM A LEITURA
Authors: Souza Stephanie Andrade 
Published: December 2017

O objetivo deste trabalho é refletir sobre as dimensões do agir docente que orientam o trabalho do professor para o ensino de leitura. Inserido no âmbito da Linguística Aplicada (LA), utilizaremos como suporte teórico os estudos advindos do Interacionismo Sociodiscursivo (ISD), representado por Bronckart (1999, 2006, 2008), Machado (2004, 2007, 2009), Cristovão (2008), entre outros, e dos estudos provenientes da Clínica da Atividade, cujos representantes são Clot (1999) e Faïta (2002). Em relação aos fundamentos metodológicos, esta pesquisa se caracteriza como qualitativa interpretativista de cunho etnográfico. Para a concretização do objetivo proposto, realizamos entrevistas semi-estruturadas e filmagem de aulas para as sessões de autoconfrontação. Os sujeitos envolvidos na pesquisa são três professores de língua materna do ensino médio da cidade de Campina Grande. Os resultados da análise revelaram que o agir que orienta o trabalho do professor para o ensino de leitura é o agir motivacional da ordem da internalização, revelando assim que os colaboradores da pesquisa trabalham a leitura a partir de motivos mentais particulares. This work is licensed under a Creative Commons Attribution 3.0 License.
Evaluation of a novel anti-biofouling microorganism (Bacillus sp. T5) for control of membrane biofouling and its effect on bacterial community structure in membrane bioreactors
Authors: Yavuztürk Gül Bahar , Imer Derya Yüksel , Park Pyung-Kyu , Koyuncu Ismail 
Published: December 2017

Abstract
The effects of a newly isolated quorum quenching (QQ) bacteria (Bacillus sp. T5) on the microbial community has been evaluated via the Illumina sequencing method. Membrane bioreactors (MBRs) operated with this novel QQ bacterium to evaluate the improvement in the performance of MBR. Anti-biofouling effect of T5 was enhanced as 71% compared to the control reactor. Also, QQ bacteria did not have any negative effect on the removal of organics during the process. Gram-negative bacteria were found to be dominant over Gram-positive bacteria. Proteobacteria, Actinobacteria, Bacteroidetes, Acidobacteria, Firmicutes, and Chloroflexi were dominant phyla in the control and QQ reactors. The proportion of Alphaproteobacteria was most significant among Proteobacteria. The relative abundances of Actinobacteria, Acidobacteria, and Firmicutes were significantly affected by Quorum quenching mechanism. On the other hand, QQ activity of Bacillus sp. T5 significantly influenced the relative abundance of Proteobacteria, Bacteroidetes, and Chloroflexi. The QQ process appeared to generate variations in the structure of the microbial community. According to the results of the molecular analyses, the syntrophic interaction of Bacillus sp. T5 and indigenous Gram-negative and Gram-positive bacterial community is critical to the performance of MBRs.
Adsorption and catalytic oxidation of organic pollutants using Fe-zeolite
Authors: Russo Analia V. , Andrade Cesar Velasco , De Angelis Laura E. , Jacobo Silvia E. 
Published: December 2017

AbstractIn this work, a natural zeolite, modified and loaded with iron (NZ-A-Fe) as a heterogeneous catalyst, was characterized for its suitability as a permeable reactive barrier (PRB) material for treatment of aromatic hydrocarbons in groundwater. Adsorption and oxidation processes were analyzed. Batch adsorption tests for benzene, toluene and xylene (BTX) aqueous concentrated solutions were performed at neutral pH. Kinetic adsorption was described with the pseudo-second-order model. Experiments were performed using a stirred batch reactor with near 11 mM initial BTX concentration applying NZ-A-Fe as solid catalyst and H2O2 as an oxidant. BTX removal reached 80% in 600 min in these experimental conditions. Catalytic oxidation was described with a pseudo-first-order kinetic model. No significant iron leaching was detected during all the experiences. These investigations show that coupling adsorption with catalytic oxidation with this novel system is a promising procedure to simultaneously remove BTX from moderately concentrated aqueous solution at neutral pH in groundwater.
The 12-item Self-Report World Health Organization Disability Assessment Schedule (WHODAS) 2.0 Administered Via the Internet to Individuals With Anxiety and Stress Disorders: A Psychometric Investigation Based on Data From Two Clinical Trials
Authors: Axelsson Erland , Lindsäter Elin , Ljótsson Brjánn , Andersson Erik , Hedman-Lagerlöf Erik 
Published: December 2017

Background
The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a widespread measure of disability and functional impairment, which is bundled with the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) for use in psychiatry. Administering psychometric scales via the Internet is an effective way to reach respondents and allow for convenient handling of data.

Objective
The aim was to study the psychometric properties of the 12-item self-report WHODAS 2.0 when administered online to individuals with anxiety and stress disorders. The WHODAS 2.0 was hypothesized to exhibit high internal consistency and be unidimensional. We also expected the WHODAS 2.0 to show high 2-week test-retest reliability, convergent validity (correlations approximately .50 to .90 with other self-report measures of functional impairment), that it would differentiate between patients with and without exhaustion disorder, and that it would respond to change in primary symptom domain.

Methods
We administered the 12-item self-report WHODAS 2.0 online to patients with anxiety and stress disorders (N=160) enrolled in clinical trials of cognitive behavior therapy, and analyzed psychometric properties within a classical test theory framework. Scores were compared with well-established symptom and disability measures, and sensitivity to change was studied from pretreatment to posttreatment assessment.

Results
The 12-item self-report WHODAS 2.0 showed high internal consistency (Cronbach alpha=.83-.92), high 2-week test-retest reliability (intraclass correlation coefficient=.83), adequate construct validity, and was sensitive to change. We found preliminary evidence for a three-factorial structure, but one strong factor accounted for a clear majority of the variance.

Conclusions
We conclude that the 12-item self-report WHODAS 2.0 is a psychometrically sound instrument when administered online to individuals with anxiety and stress disorders, but that it is probably fruitful to also report the three subfactors to facilitate comparisons between studies.

Trial Registration
Clinicaltrials.gov NCT02540317; https://clinicaltrials.gov/ct2/show/NCT02540317 (Archived by WebCite at http://www.webcitation.org/6vQEdYAem); Clinicaltrials.gov NCT02314065; https://clinicaltrials.gov/ct2/show/NCT02314065 (Archived by WebCite at http://www.webcitation.org/6vQEjlUU8)
PENINGKATAN KEAKTIFAN DAN PRESTASI BELAJAR IPS SISWA SEKOLAH DASAR DENGAN MENGGUNAKAN MODEL PEMBELAJARAN KOOPERATIF TEKNIK JIGSAW
Authors: Purnomo Rusmawan Puji 
Published: December 2017

Abstrak: Penelitian ini betujuan untuk (1) mengetahui apakah penggunaan model pembelajaran kooperatif teknik jigsaw dapat meningkatkan aktivitas belajar IPS siswa di lima SD mitra Prodi PGSD Universitas Sanata Dharma (USD), (2) mengetahui apakah penggunaan model pembelajaran kooperatif teknik jigsaw dapat meningkatkan prestasi belajar IPS siswa di lima SD mitra Prodi PGSD USD. Penelitian ini merupakan penelitian deskriptif dengan variabel penelitian yang akan ditingkatkan adalah aktivitas belajar dan prestasi belajar siswa dengan menggunakan model pembelajaran kooperatif teknik jigsaw. Penelitian dilaksanakan di lima SD mitra Prodi PGSD USD yaitu SD Kanisius Gowongan Yogyakarta, SD Kanisius Wirobrajan Yogyakarta, SD Kanisius Kembaran Bantul, SD Negeri Denggung Sleman dan SD Negeri Tidar 7 Magelang. Data penelitian dikumpulkan dengan menggunakan metode observasi dan dokumentasi, kemudian dianalisis menggunakan analisis kuantitatif. Hasil penelitian menunjukkan bahwa: (1) aktivitas belajar IPS siswa di lima SD mitra Prodi PGSD USD mengalami peningkatan. Hal ini terlihat pada persentase: (a) aspek aktivitas bertanya kondisi awal 26% dan pada kondisi akhir 74%; (b) aspek aktivitas menjawab pertanyaan guru, pada kondisi awal 24% kondisi akhir 55%; (c) aspek aktivitas menyampaikan pendapat, pada kondisi awal 14%, kondisi akhir 52%; dan (d) aspek interaksi dalam kelompok, pada kondisi awal 26%, kondisi akhir 56%; (2) Prestasi belajar siswa di lima SD mitra Prodi PGSD USD mengalami peningkatan. Hal ini terlihat dari nilai rata-rata mata pelajaran IPS di lima SD mitra, pada kondisi awal 57,10, dan pada kondisi akhir 73,50. Capaian KKM, pada kondisi awal 29,90 % dan pada kondisi akhir 70.95 %. Dengan demikian dapat disimpulkan bahwa (1) penggunaan model pembelajaran kooperatif teknik jigsaw dapat meningkatkan aktivitas belajar IPS siswa di lima SD mitra prodi PGSD USD; (2) penggunaan model pembelajaran kooperatif teknik jigsaw dapat meningkatkan prestasi belajar IPS siswa di lima SD mitra prodi PGSD USD.Kata Kunci: keaktifan belajar, prestasi belajar, model pembelajaran kooperatif teknik jigsaw
ĐA DẠNG THÀNH PHẦN LOÀI VI KHUẨN LAM TIỀM NĂNG SINH HOẠT CHẤT KHÁNG KHUẨN, KHÁNG NẤM TỪ ĐẤT RUỘNG LÚA HUYỆN PHÚ VANG THỪA THIÊN HUẾ
Authors: Liên Nguyễn Thị Thu , Nhân Lê Thị Tuyết , Sơn Nguyễn Hồng , Huệ Nguyễn Thị , Thi Phạm Thị Diễm 
Published: December 2017

Tóm tắt: Với mục đích tìm kiếm các loài vi khuẩn lam có tiềm năng sản sinh các hợp chất hoạt tính sinh học, chúng tôi trình bày kết quả phân lập, xác định thành phần loài vi khuẩn lam (VKL) từ đất ruộng lúa huyện Phú Vang – Thừa Thiên Huế và thăm dò khả năng kháng khuẩn, kháng nấm của chúng. Đã thu thập được 22 loài vi khuẩn lam thuộc 2 bộ (Nostocales và Oscillatoriales), 3 họ (Nostocaceae, Rivulariaceae và Oscillatoriaceae) và 6 chi (Anabaena, Cylindrospermum, Nostoc, Calothrix, Oscillatoria và Phormidium). 20 chủng VKL được phân lập và duy trì ổn định trong môi trường nhân tạo. 12 chủng được làm sạch khuẩn và xác định hoạt tính kháng vi sinh vật của dịch chiết của chúng đối với Bacillus subtilis, Staphylococcus aureus, Escherichia coli và Candida albicans, trong số đó 9 chủng kháng Bacillus subtilis, 9 chủng kháng Staphylococcus aureus, 5 chủng kháng Escherichia coli, 5 chủng kháng nấm Candida albicans. Chủng có hoạt tính cao nhất và cũng là chủng kháng được cả 3 loại VSV kiểm định là chủng HN42 của loài Nostoc muscorum với đường kính vòng kháng từ 4,5 đến 9,0 mm.Từ khóa: vi khuẩn lam, đa dạng, kháng khuẩn, kháng nấm, dịch chiết
ẢNH HƯỞNG CỦA MÔI TRƯỜNG DINH DƯỠNG, MẬT ĐỘ BAN ĐẦU ĐẾN SINH TRƯỞNG CỦA HAI LOÀI TẢO BIỂN Chaetoceros muelleri, Tetraselmis suecica VÀ THỬ NGHIỆM NUÔI SINH KHỐI TRONG ĐIỀU KIỆN ÁNH SÁNG TỰ NHIÊN Ở THỪA THIÊN HUẾ
Authors: Phương Trần Vinh , Khanh Nguyễn Văn , Nhân Lê Thị Tuyết , Yến Phạn Thị Hải , Huyền Kiều Thị , Nghĩa Võ Đức 
Published: December 2017

Tóm tắt: Nghiên cứu nhằm xác định ảnh hưởng của môi trường dinh dưỡng, mật độ ban đầu đến sinh trưởng của vi tảo Chaetoceros muelleri, Tetraselmis suecica và thử nghiệm nuôi sinh khối trong điều kiện ánh sáng tự nhiên với các điều kiện nuôi cơ bản nhất. Kết quả nghiên cứu cho thấy chủng Chaetoceros muelleri phát triển tốt nhất trong môi trường F/2, chủng Tetraselmis suecica phát triển tốt nhất trong môi trường Walne. Với thể tích tiếp giống ban đầu chiếm 10 % tổng thể tích môi trường nuôi, chủng Chaetoceros muelleri phát triển tốt với mật độ cực đại (5,55 ± 0,05)×105 tế bào/mL sau 11 ngày nuôi cấy, có pha cân bằng ổn định; chủng Tetraselmis suecica phát triển tốt ở thể tích tiếp giống ban đầu 15 % tổng thể tích môi trường nuôi với (13,48 ± 0,09)×104 tế bào/mL ở ngày nuôi thứ 9 và có pha cân bằng ổn định. Sinh khối Chaetoceros muelleri nuôi ngoài tự nhiên sau 8 ngày ở thể tích 50 L đạt mật độ cực đại (4,31 ± 0,08)×105 tế bào/mL và ở thể tích 1000 L đạt mật độ cực đại (3,17 ± 0,10)×105 tế bào/mL. Sau 7 ngày nuôi cấy chủng, Tetraselmis suecica đạt mật độ cực đại (14,44 ± 0,14)×104 tế bào/mL ở thể tích 50 L và đạt mật độ cực đại (9,23 ± 0,32)×104 tế bào/mL khi nuôi sinh khối trong bể composite 1000 L sau 6 ngày nuôi cấy.Từ khóa: Chaetoceros muelleri, Tetraselmis suecica, mật độ ban đầu, môi trường nuôi thử nghiệm, vi tảo, thử nghiệm nuôi sinh khối
Interference in public health policy
Authors: Granheim Ionata Sabrina , Engelhardt Katrin , Rundall Patti , Bialous Stella , Iellamo Alessandro , Margetts Barrie 
Published: December 2017

Despite countries’ commitments to improve nutrition, starting with the protection of breastfeeding, aggressive marketing of breastmilk substitutes continues to promote their indiscriminate use. The baby food industry appears to use similar interference tactics as the tobacco industry to influence public health, promote their products and expand their markets.
Learning from the tobacco experience, this paper assesses whether the baby food industry uses any of the six tobacco industry interference tactics recognized by the World Health Organization (WHO) and summarizes examples of documented evidence.
We conclude that the baby food industry uses all six tactics: (1) manoeuvring to hijack the political and legislative process; (2) exaggerating economic importance of the industry; (3) manipulating public opinion to gain appearance of respectability; (4) fabricating support through front groups; (5) discrediting proven science; and (6) intimidating governments with litigation. There is abundant anecdotal evidence. Published evidence is limited and varies by tactic. Examples of interference are provided for the Philippines, Vietnam, Laos, Turkey, Ecuador, Hong Kong, Mexico and the United Kingdom, and most for Tactic 3.
Interference in public health policies shows commonalities between the two industries. The tobacco control movement offers a useful framework for classifying and addressing interference with public policy by the baby food industry. Revealing the depth and extent of interference used by the baby food industry is critical if countries are to counter interference and implement commitments to improve nutrition.