bluuebunny/crossref_metadata_2025_split huggingface dataset:
Race, Stress, and Breast Cancer: A Scoping Review
Authors: Eltoum Noon , Alamin Faris , Hildreth Keyonsis , Abdelrahim Sara , Aneja Ritu , reeder-hayes katherine , Rosenberg Abby , Kaiser Kathryn , Rocque Gabrielle 
Published: October 2024

Abstract

Objective Toxic stress may influence breast cancer (BC) risk and progression through various physiological and biological pathways, potentially differing based on racial categories. We systematically reviewed the literature on the relationship between race, stress, and BC.Methods We searched PubMed (prior to August 2023), Embase, Web of Science, PsycINFO, and Scopus (prior November 2023) to identify relevant peer-reviewed studies. Two independent reviewers screened titles, abstracts, and full text, with disagreements resolved by discussion or a third reviewer. Data extraction and thematic synthesis were conducted independently.Results We identified 30 articles, including 21 original observational studies and 9 reviews. Primary studies explored biological markers including measures of allostatic load (AL), epigenetic changes, and social determinants of health. Studies explored biological marker, AL, epigenetic changes, and social determinants of health. Black women with BC exhibited higher AL and shorter telomeres compared to White women. Epigenetic modifications were associated with social determinants, potentially influencing BC risk and aggressiveness. Significant associations were found between neighborhood disadvantage, social support, and psychosocial stress among women of color with BC.Conclusion This review provides a landscape view of the current evidence on the complex interplay between social stressors, biological responses, and racial and ethnic disparities in BC outcomes. Findings highlight the significant role of chronic psychosocial stress in the disproportionate burden of breast cancer faced by marginalized groups. Further research is needed to explore mechanisms and evaluate multilevel interventions addressing individual stress management, neighborhood resources, and societal-level policies to improve breast cancer prevention, detection, and management.
Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden
Authors: Camacho Emma , Dong Yuemei , Chrissian Christine , Cordero Radamés , Saraiva Raúl , Anglero-Rodriguez Yessenia , Smith Daniel , Jacobs Ella , Hartshorn Isabelle , Patiño-Medina Jose , DePasquale Michael , Dziedzic Amanda , Jedlicka Anne , Smith Barbara , Mlambo Godfree , Tripathi Abhai , Broderick Nichole , Stark Ruth , Dimopoulos George , Casadevall Arturo 
Published: October 2024

Abstract

L-3,4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is prevalent in environments that include mosquito habitats, potentially serving as part of their diet. Given its role as a precursor for melanin synthesis we investigated the effect of dietary L-DOPA on mosquito physiology and immunity to Plasmodium falciparum and Cryptococcus neoformans infection. Dietary L-DOPA was incorporated into mosquito melanin via a non-canonical pathway and had profound transcriptional effects that were associated with enhanced immunity, increased pigmentation, and reduced lifespan. Increased melanization resulted in an enhanced capacity to absorb electromagnetic radiation that affected mosquito temperatures. Bacteria in the mosquito microbiome were sources of dopamine, which is a substrate for melanization. Our results illustrate how an environmentally abundant amino acid analogue can affect mosquito physiology and suggest its potential usefulness as an environmentally friendly vector control agent to reduce malaria transmission, warranting further research and field studies.
Prevalence of Disorder of Villous Maturation and the Pattern of CD15 Immunohistochemical Expression in Placentas with Late Intrauterine Fetal Death
Authors: saba Sayedatus , Begum Shahnaj , Ferdous Jesmin Naz , Billah Md. Mustain 
Published: October 2024

Abstract

Background
Disorder of villous maturation is one of the main reasons for antenatal hypoxia and fetal deaths. Meticulous microscopic and CD15 immunohistochemical studies of such cases may provide valuable information regarding the cause of intrauterine fetal deaths (IUFDs), can help to avoid diagnostic dilemmas and can offer potential treatment options for its prevention in future pregnancies.
Objective
To determine the types of disorders associated with villous maturation in the placenta in late intrauterine fetal death patients, identify delayed villous maturation via histopathological and CD15 immunohistochemical studies and determine its association with recurrent pregnancy loss.
Method
A cross-sectional study was carried out in the Department of Pathology, Sir Salimullah Medical College Mitford Hospital, Dhaka, from March 2021 to January 2023. A total of 80 patients with late IUFDs were included in this study. The placentas of the dead newborns were histopathologically analyzed, and CD15 immunohistochemistry was performed.
Result
Among the 80 patients, 40 (50.0%) were multiparas, 36 (45.0%) were primis, and only 4 (5.0%) were grand multipara patients. Twenty (25.0%) patients had a history of one IUFD, and 4 (5.0%) patients had a history of multiple IUFDs. Twenty-eight (35%) patients had disorders of villous maturation, among whom 19 (23.8%) had delayed villous maturation (DVM), 4 (5.0%) had malformed villi, 3 (3.8%) had distal villous hypoplasia, 1 (1.3%) had deficiency of intermediate villi and 1 (1.3%) had accelerated villous maturation. CD15 immunostaining was performed in 53 patients, including villitis of unknown origin, disorders of villous maturation and villous edema. Among them, 34 (64.15%) had negative CD15 expression, whereas 19 (35.8%) had positive CD15 expression. All 19 patients with delayed villous maturation had positive CD15 expression (100%), which confirmed their histological diagnosis and ensured the complete exclusion of other false positive cases. Among them, 8 (42.1%) had moderate CD15 expression, and 11 (57.89%) had severe CD15 expression. Among the 13 multipara patients with DVM, 12 (92.3%) had a history of previous IUFD. Among the remaining 31 multipara patients with no DVM, 11 (35.5%) had a previous history of IUFD. A significant difference in history of previous intrauterine fetal death was observed between the DVM present and absent groups (p = 0.001).
Conclusion
This study revealed that disorders of villous maturation are among the main causes of late IUFD and that DVM shows a distinctive pattern of CD15 immunohistochemical expression. Moreover, this study shed light on the association between DVM and recurrent pregnancy loss. The identification of DVM can guide physicians in decision making regarding the management of the patients and prevention of further pregnancy losses.
Particle Design via Powder Synthesis: Production and Characterization of a Mixed Oxide Catalyst for Alkaline Water Electrolysis
Authors: Buchheim Johannes Rolf , Drescher Viktor , Vockenberg Thorben 
Published: October 2024

Abstract

The Glatt Powder Synthesis offers a versatile tool for the development and industrial manufacturing of innovative materials for catalyst production. This technology is exemplified by the material Ba0.5Sr0.5Co0.8Fe0.2O3−δ (BSCF), showcasing its application as a catalyst for the Hydrogen Evolution Reaction (HER). The effectiveness of this method is attributed to the specific conditions present in the pulsating hot gas flow.
Our Approach to Reduce the Risk in Cesarean Section Patients with High Infection Risk
Authors: Kurkut Bülent , Yıldırım Mem Arjen , Doğan Zeki , Akbaş Hümeyra , Kavak Salih Burçin 
Published: October 2024

Abstract

OBJECTIVE
Cesarean section operations are seen as the most intensively performed surgical procedure worldwide. Although there are many approaches to reduce surgical complications, there are no methods that prevent complications 100%. Surgical site infection (SSI) is also not a preventable complication. Therefore, studies are ongoing to reduce the morbidity and mortality risks arising from SSI. We aimed to report our approach to prevent or reduce SSI in patients undergoing cesarean section with high infection risk and present the results.
MATERIALS METHOD
This retrospective cohort study was conducted between May 2017 and June 2024. A total of 200 patients with high risk of surgical site infection after cesarean section in a secondary care hospital were included in the study. The patients were divided into 4 groups according to their risks. These four patient groups were subjected to certain steps.
RESULTS
Among 200 high-risk patients who underwent cesarean section during the study period, SSI developed in a total of 6 (3%) patients, including 2 deep and 4 superficial infections. Of the 2 patients with deep infection, 1 was morbidly obese and the other was in the group of 30 patients with pregestational DM and premature rupture of membranes (PROM) occurring between gestational weeks 34-37, who
underwent cesarean section due to non-initiation of labor or unsuccessful induction. PRM is considered the highest risk factor for deep SSI (6.6%). SSI did not develop in any chorioamnionitis case. Six patients who developed SSI received medical treatment. No secondary operation or secondary suture was needed.
CONCLUSION
We found that our approach was effective in preventing or reducing the infection risk in cases with a high infection risk (PROM, cervical patency, frequent vaginal examination during labor, chorioamnionitis) in which the vagina-cervix barrier was eliminated when an indication for cesarean section occurred.
However, further studies with larger samples are needed.
A goal programming approach based on score function of the pythagorean fuzzy sets
Authors: Seal Somen , Ray Partha , Deb Sayan Chandra , Dey Agniva 
Published: October 2024

Abstract

Goal programming is a particular branch of operation research that is used to solve many problems where multiple goals or objectives are to be taken into account. In order to increase the efficacy of the conventional intuitionistic goal programming method, a new approach is presented in this paper, where a score function of the pythagorean fuzzy sets has been introduced. This paper presents the proof of convergence criterion for this new method, as well as a theorem illustrating the failure of the conventional intuitionistic goal programming method to optimize several problems. Lastly, to demonstrate the proposed method, a case study of a supply chain management problem using the multi-criteria decision-making (MCDM) approach has been taken. The outcomes of the case study show that the proposed technique outperforms the conventional intuitionistic goal programming method in terms of efficacy.
Targeting the Galectin-1/Ras Interaction for Treating Malignant Peripheral Nerve Sheath Tumors
Authors: Wang Hsiao-Chi , Torres Keila , Xia Roger , Malogolowkin Marcio , Hsu Ssu-Wei , Chen Ching-Hsien , Shih Tsung-Chieh 
Published: October 2024

Abstract

Background: Neurofibromatosis type 1 (NF1) is a common inherited neurological disorder that can lead to the development of malignant peripheral nerve sheath tumors (MPNSTs), a highly aggressive form of sarcoma. Current treatment options for MPNSTs are limited, with poor prognosis and high recurrence rates. This study aims to explore the potential of targeting the Galectin-1 (Gal-1) and Ras interaction as a novel therapeutic strategy for MPNSTs.
Methods: Molecular docking simulations were conducted to identify specific residues involved in the Gal-1 and H-Ras(G12V) interaction. LLS30, a compound designed to target the Ras binding pocket on Gal-1, was developed and tested. The efficacy of LLS30 was evaluated through in vitro assays, including cell viability, apoptosis, and co-immunoprecipitation studies, as well as in vivo assays using orthotopic MPNST xenograft and experimental lung metastasis models. Transcriptome sequencing was performed to analyze the impact of LLS30 on gene expression and signaling pathways.
Results: Molecular docking revealed key residues involved in the Gal-1/Ras interaction, and LLS30 was shown to bind to these residues, disrupting the interaction. LLS30 treatment resulted in Ras delocalization from the plasma membrane and suppression of the Ras/Erk signaling pathway. In vitro, LLS30 significantly reduced MPNST cell proliferation and induced apoptosis. In vivo, LLS30 demonstrated potent anti-tumor activity, reducing tumor burden and metastasis while improving survival in animal models. Transcriptome analysis showed that LLS30 downregulates critical pathways, including KRAS signaling and epithelial-mesenchymal transition (EMT).
Conclusions: Interference with the Gal-1/Ras interaction could lead to suppression of the Ras signaling pathway. LLS30 effectively disrupts the Gal-1/Ras interaction, resulting in significant anti-tumor and anti-metastatic effects in MPNST models. These findings indicated that targeting Gal-1 with LLS30 offers a promising therapeutic approach for treating MPNSTs and may also be applicable to other malignancies where Gal-1 and Ras are key oncogenic drivers.
WITHDRAWN: Optimal Distributed Tensor PCA with Statistical Guarantees for Heterogeneous and Decentralized Data
Authors: Li Chris Junchi 
Published: October 2024

Abstract

In this paper, we propose new methodologies for distributed tensor Principal Component Analysis (PCA) in heterogeneous data environments. These environments often arise when tensor datasets are stored across multiple machines, each with unique statistical properties, presenting significant challenges for aggregation and analysis. We extend classical Tucker decomposition to a distributed setting, providing sharp statistical convergence guarantees. Our approach han- dles both homogeneous and heterogeneous tensor data by developing estimators that account for common and individual components, achieving minimax optimal rates in various data settings. Extensive numerical simulations and real data analysis demonstrate the efficacy of our methods, which outperform traditional single-location PCA and pooled estimators, especially in hetero- geneous environments. Key applications include healthcare data analysis and recommendation systems, where privacy and communication costs are critical factors.
Check My Sample Sheet: a Web Application for Validating Illumina Sample Sheets Before Demultiplexing
Authors: Lemée Laure , Ouazahrou Rania , Kornobis Etienne , Cokelaer Thomas 
Published: October 2024

Abstract

The proper configuration of an Illumina sequencing run is paramount to its success, and the sample sheet, which summarizes sample metadata, is a critical component. To ensure accurate demultiplexing and downstream analysis, validation of this sample sheet is essential. Here, we present a user-friendly web application built with Streamlit, leveraging the IEM Python module from the Sequana Python library, designed for thorough sanity checks of Illumina sample sheets.
Our application offers a streamlined solution for sequencing platforms seeking to validate sample sheets prior to initiating demultiplexing processes. Through an intuitive interface, users can easily upload sample sheet files, triggering a suite of validation checks that include crucial parameters such as sample duplication, consistency, and adherence to Illumina formatting standards.
The Web application Check My Sample Sheet empowers users to identify and rectify potential problems preemptively, mitigate errors, and optimize sequencing outcomes. Furthermore, our application's open-source nature facilitates extensibility, allowing for customization to specific workflow requirements or other types of sample sheet formats.
Pseudogap Characteristics in Bi1.6Pb0.4Sr2Ca2Cu3O10+δ Superconductor added with Al2O3–15wt%ZrO2 Nanocomposite
Authors: Aftabi Ali 
Published: October 2024

Abstract

This study, employing the local pair model, examines how the Al2O3–15wt%ZrO2 nanocomposite affects the pseudogap peculiarities and temperature dependence of fluctuation-induced conductivity in the Bi1.6Pb0.4Sr2Ca2Cu3O10+δ superconductor. The fluctuation-induced conductivity survey reveals that the experimental data for both undoped samples and those doped with low concentrations (0.0–1.0 wt%) of the Al2O3–15wt%ZrO2 nanocomposite are well explained by the 3D Aslamazov-Larkin (AL) and 2D Maki-Thompson (MT) models, with 2D fluctuations being the most significant in all samples. The results indicate that samples with 0.1 and 0.2 wt% additives exhibit a wider region of 2D fluctuations than the undoped sample. This suggests that a minor addition of nanocomposite promotes the formation of phase-coherent fluctuating Cooper pairs. The value and temperature variation of the pseudogap Δ*(T) for different composites were deduced using the local pairs model based on experimental fluctuation-induced conductivity data. It was observed that the transition temperature from the Bose-Einstein condensate (BEC) to Bardeen-Cooper-Schrieffer (BCS) regimes of local pairs, Tpair, rose from 117.5 K at the undoped sample to approximately 133.5 K at the composite containing 0.2 wt% additive. However, with higher additive concentrations, Tpair decreased, reaching 120.5 K at the composite containing 1.0 wt% additive. The estimated superconducting gap value at T = 0, Δ(0), rose from 250 K (21.5 meV) for the undoped sample to 254 K (21.9 meV) at the composite including 0.2 wt% additive, then dropped to 243 K (20.9 meV) at the composite including 1.0 wt% additive.
The Minimum Wage Impact on Poverty in Mexico
Authors: Munguia Luis F , Lovera Marco Antonio Gomez 
Published: October 2024

Abstract

This study contributes to the public debate on the effect of the minimum wage on poverty and provides the first estimate specifically for the impact of the minimum wage on multidimensional poverty in Mexico. We find that the elasticity of poverty to the minimum wage is between − 0.36 and − 0.58. This implies that between 2019 and 2022, the number of people in poverty decreased between 23.7% and 37.6% because of the minimum wage. In other words, of the 5.1 million people who escaped poverty, 4.1 million can be attributed exclusively to the minimum wage increase. Additional results indicate that minimum wage increases did not significantly impact the level of employment but did have an impact on labor income. As for social programs, the universal pension shows that a 10% increase in its funding reduces poverty by 13%; a 10% increase in basic education scholarships income contributes to a 3.5% reduction in income poverty.
A Cognitive -Semantic Study of Love Metaphor in Mawlawi Poems
Authors: Karzan Abdullah Jezhny  
Published: October 2024

This study is entitled "A Cognitive Semantic Study of Love Metaphor in Mawlawi Poems". It is an attempt to construe the semantic aspects of Mawlawi's poetic texts in light of the cognitive semantic approach. The study, through a linguistic and cognitive analysis, clarifies the way meaning is constructed in the selected poems. It adopts the theoretical framework proposed by the cognitive semantic theory of metaphor. That is, according to the cognitive theory of metaphor, it explores the metaphorization of LOVE in the selected poems. In cognitive approach to metaphor, an abstract concept named the target domain is understood in terms of another called the source domain (usually concrete). The source domain is a conceptual domain used metaphorically so as to understand the abstract target concept, i.e., the target domain is a conceptual domain interpreted through the source domain. The current study investigates the ways in which LOVE as an abstract target concept is construed in terms of other source conceptual domains. That is, the primary aim of the study is to scrutinize how LOVE is metaphorized in the poems, what are the source domains the poet relies upon so as to interpret the target domain of LOVE. In other words, what are the more concrete conceptual source domains that are metaphorically used in order to comprehend the abstract target concept of LOVE? Accordingly, the recent study is mainly concerned with conceptualization (the way LOVE is conceptualized) which is the cognitive processes of meaning-making. This means that, it illuminates meaning construction process in Mawlawi literature. The study first provides a brief introduction to Cognitive Linguistics and then the nature of meaning in cognitive semantic approach is highlighted. Following this, the cognitive approach to metaphor is presented. The last section is devoted to elucidating the metaphorical structuring of LOVE in Mawlawi's poems based on the contemporary theory of metaphor.
ناسیۆنالیزمی شێعر
Authors: Sharafi Idrees shekh 
Published: October 2024

پوختە:
ناسیۆنالیزمی شێعر تێزێکە سەبارەت بە دەرکەوتنی خود-ئاگایی سیاسی کورد لە مێژووی هزریدا، لە پێناو مانابەخشین بە بوون و شوناس لە چوارچێوەی دەوڵەت/نەتەوەوە بەرەو نیشتمان یان کیانێکی ویژدانی. شاعیرانی پێشەنگی ئەم رەوتە (خانی، حاجی، ئەحمە موختار جاف، قانع و بێکەس) دامەزرێنەری ئاگایی خودیی و پرۆژەی بەسیاسیکردنی زمانن، هەوڵیانداوە دەستکاری ئەو واقیعە بکەن کە وەک حەقیقەت دەرکەوتووە. لە دیدی ئەوان دۆخی سیاسی کورد بەرهەمی گوتاری سیاسی دەسەڵاتی زاڵی "ئەوانیتر"ی سەر کوردستان بووە. لەم سۆنگەیەوە لە میانی پرۆژەی شێعری سیاسی نەتەوەیی و ئاوێتەیەک لە کۆلاژی مێژوو و ئەفسانە و جوگرافیایەکی خەیاڵکرد، بنەڕەتی ئاگایی کوردیان داڕشتووە. ئەمە ئەگەرچی ئاگایی بووە سەبارەت بە سەردەم و زەمەن و بوونی سیاسییانەی کورد لە مێژوودا، بەڵام هاوکات ئاوێتەی کێشەی فەلسەفەی خودیی subjective philosophy بووە.
واتە ئیشکالیەتی سەرەکی لە رەوتی رۆنانی نەتەوە، گیرخواردنیەتی لە چوارچێوەی فەلسەفەی ئاگایی بەو جۆری لە فەلسەفەی رەخنەیی یورگن هابرماس دا تیۆریزەکراوە، کە تێیدا خود دەکەوێتە رامان و راڤەی خۆی و جیهان و بەرەو مۆنۆلۆگ و داخران دەچێت. لە کۆنتێکستی کوردیدا کاتێ ئەمە لە رێگەی زمانی شێعری و تەکنیک و فۆڕمی ئامادە ئەنجام دەدرێت، کێشەکە ئاستێکی باڵاتری ئاڵۆزی بەخۆیەوە دەگرێت و دەشێت بیر لەقاڵب بدات و حوکمی پێشوەختە ناوەرۆکەکەی بجوڵێنێ. بەم جۆرە پەیوەندی نێوان زمان و ئایدیا و واقیع تووشی شێوان دەکات. بۆ دەرچوون لەم تەنگژەیە، فەلسەفەی نێوانخودێتی دەرچەیەک بۆ پەڕینەوە بەرەو سیاسەتێکی ئەلتەرناتیڤ دەکاتەوە کە ئەرگۆمێنتخوازی و زمانی هاوبەش و دیالۆگ بنەڕەتەکەیەتی بە ئاراستەی کردە و شۆڕش و دەرچوون لە ئەمری واقیع.
پڕۆژەی ناسیۆنالیزم کە هەمان دروستکردنەی نەتەوە و دەوڵەتە، لە کۆنتێکستی کوردیدا بەهۆی داخرانی بیاڤی نێوانی inter و کامڵنەبوونی پرۆسسی بەسیاسیکردنی هاوبەشەکان و ویستی ئازادی خودەکان، لە جیاتی "بەرەی یەکبوونی نەتەوەیی" کە دوائامانجی بونیاتنانی نەتەوە و دەوڵەتە، بە ئاراستەی حزبی دەسەڵاتگەرا چووە کە کوردی لە رووی شوناس و ئینتماوە زیاتر پارچە پارچە کردوە، ئەمەش وەک واقیعگەرایی لێکداروەتەوە، نەک دەرکەوتنی واقیع لە ئاگاییدا.
وشە سەرەکییەکان: ئاگایی خودی، زمانی شێعری، دەوڵەت/نەتەوە، ناسیۆنالیزم، سیاسەتی نێوانخودی.
زمان و پەیوەندیکردن لای منداڵی ئۆتیزم
Authors: Abdulrahman Shelan Othman 
Published: October 2024

پوختە:
ئەم توێژینەوەیە بە ناونیشانی (زمان و پەیوەندیکردن لای منداڵی ئۆتیزم )ـە، ئامانج لەم توێژینەوەیە ئەوەیە، کە وڵامی ئەم پرسیارانە بداتەوە: ئۆتیزم چیە؟ چ پەیوەندییەکی بە زمانەوە هەیە؟ تایبەتمەندییە زمانییەکانی توشبوی ئۆتیزم چین؟ گرفتی زمانی لە ئۆتیزم گرفتی ئاخاوتنە یا زمان؟ ئەمانە و چەندین پرسیاری تر وەڵامەکانیان لەم توێژینەوەیەدا بەرجەستەن. ئەم توێژینەوە لە دو تەوەر پێکدێت، تەوەری یەکەم تایبەتە بە ناساندنی ئۆتیزم لەم لایەنانەوە: چیەتی ئۆتیزم، چەمک و زاراوە، تایبەتمەندییەکانی، هۆکارەکانی توشبون بە ئۆتیزم.
تەوەری دوەم: بریتیە لە تایبەتمەندییە زمانییەکانی منداڵی ئۆتیزم، ئەم تەوەرەش ئەم بابەتانە لەخۆدەگرێت: تایبەتمەندییە گوتەییەکانی منداڵی ئۆتیزم، تایبەتمەندییە ناگوتەییەکانی منداڵی ئۆتیزم، هەروەها بە پێی ئەنجامی ڕاپرسیەکە تایبەتمەندەییەکان شیدەکرێنەوە و دەخرێنەڕو، چونکە ئەم توێژینەوەیە بەشی کارەکی لەخۆدەگرێت، کە فۆڕمی راپرسی دابەشکراوە بەسەر مامۆستایان و ڕاهێنەرانی سەنتەری ئۆتیزم، بڕگەکانی ئەم ڕاپرسیە لە ١٦پرسیار پێکدێت، پرسیارەکان تایبەتن بە لایەنی گوتەیی و ناگوتەیی لە پەیوەندیکردنی منداڵی توشبوی ئۆتیزم. لە کۆتایدا ئەنجام و لیستی سەرچاوەکان و کورتە بەزمانی ئینگلیزی و نمونەیەک لە ڕاپرسییەکە خراوەتەڕو.