bluuebunny/crossref_metadata_2025_split huggingface dataset:
Siblings of Children with Autism: the Siblings Embedded Systems Framework
Authors: Kovshoff Hanna , Cebula Katie , Tsai Hsiao-Wei Joy , Hastings Richard P. 
Published: May 2017

AbstractPurpose of ReviewA range of interacting factors/mechanisms at the individual, family, and wider systems levels influences siblings living in families where one sibling has autism. We introduce the Sibling Embedded Systems Framework which aims to contextualise siblings’ experience and characterise the multiple and interacting factors influencing family and, in particular, sibling outcomes.Recent FindingsFindings from studies that have reported outcomes for siblings of children with autism are equivocal, ranging from negative impact, no difference, to positive experience. This is likely due to the complex nature of understanding the sibling experience. We focus on particular elements of the framework and review recent novel literature to help guide future directions for research and practice including the influence of culture, methodological considerations, and wider participatory methods.SummaryThe Siblings Embedded System Framework can be used to understand interactive factors that affect sibling adjustment and to develop clinically, educationally and empirically based work that aims to enhance and support sibling adjustment, relationships, and well-being in families of children with autism.
Consensus guidelines for lumbar puncture in patients with neurological diseases
Authors: Engelborghs Sebastiaan , Niemantsverdriet Ellis , Struyfs Hanne , Blennow Kaj , Brouns Raf , Comabella Manuel , Dujmovic Irena , van der Flier Wiesje , Frölich Lutz , Galimberti Daniela , Gnanapavan Sharmilee , Hemmer Bernhard , Hoff Erik , Hort Jakub , Iacobaeus Ellen , Ingelsson Martin , Jan de Jong Frank , Jonsson Michael , Khalil Michael , Kuhle Jens , Lleó Alberto , de Mendonça Alexandre , Molinuevo José Luis , Nagels Guy , Paquet Claire , Parnetti Lucilla , Roks Gerwin , Rosa‐Neto Pedro , Scheltens Philip , Skårsgard Constance , Stomrud Erik , Tumani Hayrettin , Visser Pieter Jelle , Wallin Anders , Winblad Bengt , Zetterberg Henrik , Duits Flora , Teunissen Charlotte E. 
Published: May 2017

AbstractIntroductionCerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post‐LP headache or back pain.MethodsWe provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II‐2), (2) systematic literature review on LP needle characteristics and post‐LP complications (evidence level II‐2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III).ResultsOur consensus guidelines address contraindications, as well as patient‐related and procedure‐related risk factors that can influence the development of post‐LP complications.DiscussionWhen an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.
Use of endoanal ultrasound as complimentary evaluation for detection of anal sphincter injury after vaginal birth
Authors: Izadpanah Ahmad , Izadpanah Ensieh , Lotfi Mehrzad , Samsami Alamtaj , Safarpour Alireza , Rezazadehkermani Mohammad 
Published: May 2017

Abstract
Purpose Anal sphincter injury after delivery is the main factor in the pathogenesis of fecal incontinence. Clinical obvious and specific injury to anal canal sphincter is seen in 3% of vaginal deliveries. There are many women who do not have a clear and specific laceration but they are damaged by sphincter muscles of anal canal. The purpose of the present study is to investigate the frequency of occult anal sphincter injury after vaginal delivery by Endo-anal sonography.
Methods Fifty women with first pregnancy were assessed at 27–33 weeks of pregnancy, and at 6 weeks and 6 months after vaginal delivery by questionnaire, examination and Endo-anal sonography. Women age, duration of delivery, the effect of epidural anesthesia, episiotomy and birth weight were studied and Endo-anal sonography results were recorded. Anal manometry was performed for all mothers before delivery and 5 ones with sphincter injury at 6 months and 3 years after delivery.
Results Five (10%) patients, with mean age 29.4 ± 6.5 years, mean neonatal weight of 3874 ± 287, and mean duration of delivery 11.6 ± 1.51 h, had signs of sphincter injury in Endo-anal sonography. The injury was persisted at six months after delivery. Also, significant differences were seen between anal manometry before delivery and 6 months and 3 years after delivery (p = 0.006 for mean squeezing pressure) in the five mothers.
Conclusion Endo-anal sonography might be a good screening tool for early detection of postpartum anal sphincter damages. However, further prospective cost benefit studies should be performed to propose it as a standard of care.
It Takes Two to Tango: Engaging Patients and Providers With Portals
Authors: Shah Sachin D. , Liebovitz David 
Published: May 2017

AbstractPatient portals are designed to be tools to more fully engage patients in their health care and help enable them to better manage their own health information. As the U.S. health care system rapidly adopted electronic health records (EHRs) over the past decade, many with linked patient portals, enthusiasm and expectations for this new technology as a means to engage and empower patients grew. Most patient portals have a set of core features designed to facilitate health care transactions, information tracking, and communication with care team members. The evidence supporting the anticipated benefits of patient portals on patient outcomes, however, remains mixed and incomplete. Moreover, a paradox exists in that, despite a high consumer interest in patient portals, widespread adoption remains relatively low. Potential reasons include the need for greater provider endorsement, examination and adaptation of clinical workflows, and the recognition of patient engagement as a reciprocal process.
Technology‐Enabled Population Health Management: Two Communities' Use of an Electronic Care Alert System
Authors: Rowland Todd , Nielsen‐Farrell Jill , Church Kathy , Riddell Barbara 
Published: May 2017

AbstractPopulation health management is an approach to improve the health outcomes of a specific group of people, such as frequent users of the emergency department or those at high‐risk for hospital admissions. When combined with quality improvement strategies, the targeted application of health information exchange and health information technology (health IT) can swiftly move health care systems and providers from basic to advanced population health management. One such tool is an electronic alert system (alert system), which informs a provider or site about a patient's visit to the emergency department or hospital admission on a daily basis. This article highlights the use of such an alert system in 2 communities to help address gaps in population health management.
Pseudomonas aeruginosa Outbreak in a Neonatal Intensive Care Unit Attributed to Hospital Tap Water
Authors: Bicking Kinsey Cara , Koirala Samir , Solomon Benjamin , Rosenberg Jon , Robinson Byron F. , Neri Antonio , Laufer Halpin Alison , Arduino Matthew J. , Moulton-Meissner Heather , Noble-Wang Judith , Chea Nora , Gould Carolyn V. 
Published: May 2017

OBJECTIVETo investigate an outbreak of Pseudomonas aeruginosa infections and colonization in a neonatal intensive care unit.DESIGNInfection control assessment, environmental evaluation, and case-control study.SETTINGNewly built community-based hospital, 28-bed neonatal intensive care unit.PATIENTSNeonatal intensive care unit patients receiving care between June 1, 2013, and September 30, 2014.METHODSCase finding was performed through microbiology record review. Infection control observations, interviews, and environmental assessment were performed. A matched case-control study was conducted to identify risk factors for P. aeruginosa infection. Patient and environmental isolates were collected for pulsed-field gel electrophoresis to determine strain relatedness.RESULTSIn total, 31 cases were identified. Case clusters were temporally associated with absence of point-of-use filters on faucets in patient rooms. After adjusting for gestational age, case patients were more likely to have been in a room without a point-of-use filter (odds ratio [OR], 37.55; 95% confidence interval [CI], 7.16–∞). Case patients had higher odds of exposure to peripherally inserted central catheters (OR, 7.20; 95% CI, 1.75–37.30) and invasive ventilation (OR, 5.79; 95% CI, 1.39–30.62). Of 42 environmental samples, 28 (67%) grew P. aeruginosa. Isolates from the 2 most recent case patients were indistinguishable by pulsed-field gel electrophoresis from water-related samples obtained from these case-patient rooms.CONCLUSIONSThis outbreak was attributed to contaminated water. Interruption of the outbreak with point-of-use filters provided a short-term solution; however, eradication of P. aeruginosa in water and fixtures was necessary to protect patients. This outbreak highlights the importance of understanding the risks of stagnant water in healthcare facilities.Infect Control Hosp Epidemiol 2017;38:801–808
Working Despite Having Influenza-Like Illness: Results of An Anonymous Survey of Healthcare Providers Who Care for Transplant Recipients
Authors: Mossad Sherif B. , Deshpande Abhishek , Schramm Sarah , Liu Xiaobo , Rothberg Michael B. 
Published: May 2017

OBJECTIVETo compare the rates of and reasons for presenteeism associated with influenza-like illness (ILI) among healthcare professionals (HCPs) caring for hospitalized inpatient transplant recipients and internal medicine patients.DESIGNWe designed a 10-question anonymous survey in which ILI was defined as fever (>37.8°C) and cough and/or sore throat and ILI B was defined as fever (>37.8°C) or cough or sore throat; both definitions were considered in the absence of another known cause.SETTINGTertiary-care center.PARTICIPANTSPhysicians, advanced practice providers (APPs) and nurses.INTERVENTIONSurvey deployed at peak of influenza activity in 2016.MEASUREMENTSRates of ILI, presenteeism, wearing masks, and time away due to ILI.RESULTSOf 707 HCPs surveyed, 286 (40%) responded; 15 (5.2%) reported having ILI, and 73 (25.5%) reported having ILI B in the preceding 2 weeks. Presenteeism rates were 92% in both groups of HCPs and were higher among women (adjusted odds ratio [AOR], 2.64; 95% CI, 1.23–5.71;P=.01) and those ≤40 years old (AOR, 1.92; 95% CI, 1.03–3.68;P=.04). Healthcare professionals who cared for transplant recipients and female HCPs were more likely to wear masks (AOR, 2.13; 95% CI, 1.05–3.40;P=.04 for transplant recipients and AOR, 3.96; 95% CI, 1.35–11.63;P=.01 for female HCPs). Nurses were more likely than physicians and APPs to take time off (AOR, 3.33; 95% CI, 1.10–10.09;P=.03.)CONCLUSIONSPresenteeism among HCPs with ILI is common, including among those caring for transplant recipients. Nonpunitive systems should encourage HCPs not to work with ILI and to wear masks to prevent spread of infections.Infect Control Hosp Epidemiol2017;38:966–969
Steps Toward Measurement of 135Cs with AMS at CIAE
Authors: Yin Xinyi , He Ming , Dong Kejun , Pang Yijun , Wu Shaoyong , Jiang Shan 
Published: May 2017

Abstract135Cs with a half-life of T1/2=2.3×106 yr is an important nuclide in studies of the dispersal of nuclear material in the environment. Preliminary measurements using 133Cs as a proxy for the long-lived 135Cs, with accelerator mass spectrometry (AMS) have been developed at the China Institute of Atomic Energy (CIAE). In order to improve the sensitivity of 135Cs AMS measurement, a new conducting material, Fe powder, was used in the experiment. According to the present results, the background level that can be obtained with blanks was 135Ba/Cs~1.83×10–10 with the CIAE-AMS system. These measurements showed that the Fe was an inferior conducting medium because the interference of 135Ba in Fe powder is 10 times higher than that in Ag powder.
The effect ofTetraneura ulmiL. galling process on the activity of amino acid decarboxylases and the content of biogenic amines in Siberian elm tissues
Authors: Kmieć K. , Sempruch C. , Chrzanowski G. , Czerniewicz P. 
Published: May 2017

AbstractTetraneura ulmi(L.), a member of Eriosomatinae subfamily, is one of the gall-forming aphids occurring on elms. Sap-sucking behaviour of founding mothers results in the formation of new plant organs. This study documents the changes in the content of plant biogenic amines (putrescine, cadaverine, spermidine, tryptamine, spermine and histamine) and key enzymes of their biosynthesis: lysine decarboxylase (LDC), tyrosine decarboxylase and ornithine decarboxylase (ODC) in galls and other parts of Siberian elm (Ulmus pumilaL.) leaves during the galling process. The direction and intensity of these changes for particular amines and enzymes were dependent on the stage of gall development and part of the galling leaf. Generally, the amine content tended to increase in gall tissues during the 1st and 2nd period of the galling process and decreased in later phases. LDC and ODC activities were markedly enhanced, especially in gall tissues at the initial stage of the galling process.
Evaluation of benzimidazole resistance status in Ascaridia galli
Authors: TARBIAT B. , JANSSON D. S. , TYDÉN E. , HÖGLUND J. 
Published: May 2017

SUMMARYSusceptability of Ascaridia galli to benzimidazole (BZ) was investigated using faecal egg count reduction test (FECRT), in ovo larval development test (LDT) and genetic markers (mutations at codons 167, 198 and 200 of β-tubulin gene). Six flocks (F1−F6) of a commercial laying hen farm with different number of exposure to BZ were recruited. The FECR was calculated by analyzing individual faeces (F1, F2, F4 and F5) before and 10 days after treatment. The LDT was performed on parasite eggs from pooled samples from F1 to F6 and LC50 and LC99 were calculated. DNA was extracted from 120 worms and sequenced for β-tubulin gene. In all flocks, the FECRs were above 95% (lower CI above 90%). No significant difference was observed (p > 0·05) among obtained LC50 (F1/F4 and F2/F5 vs F3/F6) in the LDT. However, LC50 and LC99 were higher than suggested values for declaration of resistance in other nematode species. No variation was observed in codon positions involved in BZ resistance. Overall, our results indicated lack of evidence of resistance to BZ in A. galli. More research is needed to confirm these results and to further optimize the existing tools for detection and monitoring of anthelmintic resistance in A. galli.
The changing epidemiology of spinal tuberculosis: the influence of international immigration in Catalonia, 1993–2014
Authors: PEGHIN M. , RODRIGUEZ-PARDO D. , SANCHEZ-MONTALVA A. , PELLISÉ F. , RIVAS A. , TORTOLA T. , AGUILAR J. , ALMIRANTE B. , PIGRAU C. 
Published: May 2017

SUMMARYThe overall incidence of spinal tuberculosis (TB) appears to be stable or declining in most European countries, but with an increasing proportion of cases in the foreign-born populations. We performed a retrospective observational study (1993–2014), including all cases of spinal TB diagnosed at a Barcelona hospital to assess the epidemiological changes. Fifty-four episodes (48·1% males, median age 52 years) of spinal TB were diagnosed. The percentage of foreign-born residents with spinal TB increased from 14% to 45·2% in the last 10 years (P = 0·017). Positive Mycobacterium tuberculosis testing in vertebral specimens was 88·2% (15/17) for GeneXpert MTB/RIF. Compared with natives, foreign-born patients were younger (P < 0·01) and required surgery more often (P = 0·003) because of higher percentages of paravertebral abscess (P = 0·038), cord compression (P = 0·05), and persistent neurological sequelae (P = 0·05). In our setting, one-third of spinal TB cases occurred in non-native residents. Compared with natives, foreign-born patients were younger and had greater severity of the disease. The GeneXpert MTB/RIF test may be of value for diagnosing spinal TB.
Migration patterns and seasonal forest use by birds in the Brazilian Pantanal
Authors: DE PINHO JOÃO BATISTA , ARAGONA MÔNICA , HAKAMADA KARLO YOSHIHIRO PIOTO , MARINI MIGUEL ÂNGELO 
Published: May 2017

SummaryThe use of forest habitats and migratory patterns are still unclear for tropical birds. Some are described herein for the Pantanal wetlands of Brazil. Thus, our aim was to describe different patterns of forest habitat use by birds and classify the birds’ migration patterns for the northern Pantanal region, Brazil. From September 1999 to December 2003, we sampled four forest types, during which we collected standardised data with mist-net captures and point counts, with additionalad lib.observations. We recorded 214 bird species: 113 (52.8%) were total habitat generalists; 41 (19.2%) were forest generalists; 19 (8.9%) were flooded habitat specialists; and 28 (13.1%) were not classified due to the low number of records; three other categories of habitat use divide the remaining 6% of records. About half of the species showed some migratory behaviour, these were classified by us according to the season they spent in the area: 121 species (56.5%) asresidents, 28 (13.1%) asrun-off and dry migrants, 11 (5.1%) asrun-off(winter)migrants, eight (3.7%) asdry(breeding)migrants, eight (3.7%) asdry and flooding(summer)migrants, eight (3.7%) asflooding migrants, three (1.4%) asflooding and run-off migrants, and 27 (12.6%) asuncommon. We constructed community occupancy models with six of the eight patterns of migration described; flooding migrants and run-off migrants were not modelled since the few species recorded also had very few detections. As expected, the model confirmed that species from all six tested migration patterns arrive and depart from the Pantanal across the seasons. Contrary to most Neotropical forests, there was a high percentage (43.5%) of non-resident species. The results show the need of investing heavily in preserving different landscape units within the Pantanal, but also in the surrounding Cerrado region, in order to conserve resident and short distance intra-tropical migrants.
How Latina mothers navigate a ‘food swamp’ to feed their children: a photovoice approach
Authors: Colón-Ramos Uriyoán , Monge-Rojas Rafael , Cremm Elena , Rivera Ivonne M , Andrade Elizabeth L , Edberg Mark C 
Published: May 2017

AbstractObjectiveTo understand how mothers who recently migrated from Central America to the USA feed their children in a neighbourhood saturated with unhealthful food choices (‘food swamp’) and to formulate a mother-driven plan of action to facilitate their acquisition of foods.Design/Setting/SubjectsWe purposively sampled mothers with children (<10 years old) who were recent immigrants/refugees from Central America and lived in a ‘food swamp’ neighbourhood. We used the photovoice approach to elicit textual data from thirty in-depth interviews, a participatory workshop, and visual data from photographs. Analyses were guided by the Social Ecological Framework and Social Cognitive Theory to identify barriers, facilitators and strategies that support parents in feeding their children.ResultsMothers valued foods that they considered to be ‘traditional’ and ‘healthful’. They navigated their food retail environment looking for these foods (of good quality and well-priced). Food values were reinforced by pre-migration food customs and culture, health professionals’ advice and, in some cases, by the desire to avoid conflict with their children. The neighbourhood food environment could directly influence children’s food preferences and often created conflict between what the child wanted to eat and the foods that mothers valued. Mothers in this ‘food swamp’ wanted to be engaged in addressing the selection of foods offered in schools and in neighbourhood food venues to reflect their own food values.ConclusionsThese mothers’ feeding choices were influenced directly by their food values, and indirectly by the neighbourhood and school food environments via their children’s preferences.
‘Oh you're a guy, how could you be raped by a woman, that makes no sense’: towards a case for legally recognising and labelling ‘forced-to-penetrate’ cases as rape
Authors: Weare Siobhan 
Published: May 2017

AbstractThe existing legal definition of rape in England and Wales is gendered, only recognising men as offenders. The law also only recognises as victims of rape those who are penetrated by a penis, either vaginally, anally or orally. This therefore excludes the female perpetrator–male victim paradigm, and more specifically those cases where male victims are ‘forced to penetrate’ female perpetrators. This paper argues that consideration needs to be given to legally recognising and thus labelling forced-to-penetrate cases as rape. Applying a methodology that draws upon the lived experiences of male victims, it is argued that there are significant similarities between compelled-penetration cases and those cases legally recognised as rape, not only because they both involve non-consensual penile penetration, but because there are clear similarities in the aggressive strategies used by perpetrators and the subsequent harms experienced by victims.
Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2
Authors: Xu Bing , Wang Shiyun , Li Rongwei , Chen Kai , He Lingli , Deng Manman , Kannappan Vinodh , Zha Jie , Dong Huijuan , Wang Weiguang 
Published: May 2017

AbstractAcute myeloid leukemia (AML) is a heterogeneous malignancy. Despite the advances in past decades, the clinical outcomes of AML patients remain poor. Leukemia stem cells (LSCs) is the major cause of the recurrence of AML even after aggressive treatment making, promoting development of LSC-targeted agents is an urgent clinical need. Although the antitumor activity of disulfiram (DS), an approved anti-alcoholism drug, has been demonstrated in multiple types of tumors including hematological malignancies such as AML, it remains unknown whether this agent would also be able to target cancer stem cells like LSCs. Here, we report the in vitro and in vivo activity of DS in combination with copper (Cu) against CD34+/CD38+ leukemia stem-like cells sorted from KG1α and Kasumi-1 AML cell lines, as well as primary CD34+ AML samples. DS plus Cu (DS/Cu) displayed marked inhibition of proliferation, induction of apoptosis, and suppression of colony formation in cultured AML cells while sparing the normal counterparts. DS/Cu also significantly inhibited the growth of human CD34+/CD38+ leukemic cell-derived xenografts in NOD/SCID mice. Mechanistically, DS/Cu-induced cytotoxicity was closely associated with activation of the stress-related ROS-JNK pathway as well as simultaneous inactivation of the pro-survival Nrf2 and nuclear factor-κB pathways. In summary, our findings indicate that DS/Cu selectively targets leukemia stem-like cells both in vitro and in vivo, thus suggesting a promising LSC-targeted activity of this repurposed agent for treatment of relapsed and refractory AML.