bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Store Layout, Kualitas Pelayanan Dan Motivasi Rasional Terhadap Keputusan Pembelian Pada Toko Zam Zam Kota Bima
Authors: Gafiqi Abdul , Ismunandar Ismunandar , Mulyadin Mulyadin 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh store layout, kualitas pelayanan dan motivasi rasional terhadap keputusan pembelian pada toko Zam-Zam Kota Bima. Penelitian ini dilakukan di toko Zam-Zam Jl. Sultan Muhamad Salahuddin, Dara, Kec. Rasanae Barat Kota Bima. Dalam penelitian ini digunakan jenis penelitian asosiatif dengan menggunakan instrument penelitian kuesioner skala likert. Populasi dalam penelitian adalah semua masyarakat yang pernah membeli pada toko Zam-Zam kota Bima yang jumlahnya tidak diketahui pasti jumlahnya. Dikarenakan populasinya tidak diketahui secara pasti maka sampel penelitian sebanyak 96 orang dengan teknik penentuan sampel yaitu purposive sampling. Teknik pengumpulan data menggunakan observasi, kuesioner dan studi pustaka. Data yang telah dikumpulkan kemudian dianalisis dengan teknik uji validitas, uji reliabilitas, uji asumsi klasik, regresi linear berganda, koefisien korelasi berganda, uji determinasi, uji t dan uji f. Hasil penelitian menunjukan bahwa store layout berpengaruh terhadap keputusan pembelian pada toko Zam-Zam Kota Bima, sedangkan kualitas pelayanan dan motivasi rasional tidak berpengaruh terhadap keputusan pembelian pada toko Zam-Zam Kota Bima
Kajian Harmonisasi dan Inovasi Kerja Dosen: Studi Kasus di Perguruan Tinggi Swasta di Kota Medan
Authors: Simamora Rusdiana Br , Irwadi Irwadi , Leonid Michelyn 
Published: September 2024

Penelitian ini bertujuan untuk menganalisis peran harmonisasi dedikasi dalam memediasi pengaruh servant leadership, lack of management support, dan work overload terhadap inovasi kerja dosen di perguruan tinggi swasta di Kota Medan. Metode penelitian yang digunakan adalah pendekatan kuantitatif dengan model Structural Equation Model (SEM). Adapun target populasi dan sampel dalam penelitian ini yaitu 103 dosen di Sekolah Tinggi Ilmu Ekonomi (STIE) di Kota Medan, yang mencakup STIE IBMI, STIE Eka Prasetya, STIE Profesional Indonesia, STIE Pangeran Antasari, STMB Multi Smart, dan STIE Graha Kirana. Selanjutnya data dikumpulkan melalui kuesioner yang dirancang berdasarkan dimensi atau indikator dari setiap variabel penelitian. Hasil penelitian menunjukkan bahwa servant leadership secara langsung berpengaruh positif dan signifikan terhadap harmonisasi dedikasi. Lack of management support juga menunjukkan pengaruh positif dan signifikan terhadap harmonisasi dedikasi. Sebaliknya, work overload tidak berpengaruh signifikan terhadap harmonisasi dedikasi. Harmonisasi dedikasi terbukti berpengaruh positif dan signifikan terhadap inovasi kerja dosen. Selain itu, harmonisasi dedikasi memediasi pengaruh servant leadership dan lack of management support terhadap inovasi kerja dosen. Namun, harmonisasi dedikasi tidak memediasi pengaruh work overload terhadap inovasi kerja dosen. Temuan ini mengindikasikan bahwa peningkatan servant leadership dan dukungan manajemen yang memadai berpotensi memperbaiki inovasi kerja dosen melalui harmonisasi dedikasi, sementara beban kerja yang berlebihan tidak berpengaruh signifikan pada inovasi kerja, dan harmonisasi dedikasi tidak berfungsi sebagai mediator dalam konteks ini. Penelitian ini memberikan wawasan penting bagi pengelola perguruan tinggi swasta dalam merancang strategi untuk meningkatkan inovasi kerja dosen melalui pengembangan kepemimpinan dan dukungan manajerial yang efektif
Sosialisasi Pemahaman Tentang Sengketa Hak Milik Atas Tanah Kepada Masyarakat Di Kelurahan Sukamakmur Pematangsiantar
Authors: Christian Daniel Hermes  , Nainggolan Rosita , Sitinjak Humala , Sitinjak Imman Yusuf 
Published: September 2024

Fenomena sengketa hak milik sangat besar di masyarakat khususnya di Kelurahan Sukamakmur Kecamatan Siantar Marihat Kota Pematangsiantar. Peran Dosen Fakultas Hukum sangat di perlukan untuk memberikan pengetahuan hukum terkait dengan sengketa hak milik atas tanah. Metode yang dilakukan dalam pengabdian ini adalah metode diskusi serta pendampingan hukum bagian keperdataan dengan masyarakat langsung. Hasil yang dicapai dalam program PKM ini adalah peningkatan kesadaran masyarakat Kelurahan Sukamakmur dalam memahami sengketa hak milik atas tanah melalui peran Lembaga Bantuan Hukum Universitas Simalungun dengan cara penyuluhan hukum dengan mekanisme ceramah, diskusi. Meteri ceramah dan diskusi. Disamping itu kegiatan ini dilakukan agar masyarakat memahami dan mengetahui pentingnya kesadaran hukum. Metode yang digunakan dalam pencapaian tujuan tersebut adalah pemberdayaan masyarakat melalui sosialisasi. Metode ini digunakan dalam melakukan pemberdayaan kelompok sasaran seperti kelompok masyarakat, pemuda, dan pemerintah Kelurahan
Pendampingan Pengelolaan Desa Wisata Nagori Tigaras
Authors: Munthe Risma N , Napitu Resna , Purba Desmi , Simbolon Pirma , Simatupang Pandapotan , Sinaga Mahaitin H 
Published: September 2024

Kegiatan pengabdian pada masyarakat ini adalah Pendampingan Pengelolaan Desa Wisata Nagori Tigaras. Pengabdian ini bertujuan untuk mendampingi masyarakat Nagori Tigaras dalam menjalankan bisnis Desa Wisata. Khalayak sasaran dalam kegiatan ini adalah masyarakat Nagori Tigaras berjumlah 15 orang. Pendampingan kegiatan ini dilakukan dengan cara ceramah bervariasi dan evaluasi. Metode ceramah digunakan untuk menjelaskan konsep bisnis, macam media, kelebihan dan kekurangan penggunaan media dalam bisnis wisata, keramahtamahan 3S (Senyum, Salam, Sapa), pemberdayaan masyarakat setempat untuk bisnis Homestay dan langkah-langkah pengelolaan bisnis usaha Desa Wisata. Pelaksanaan kegiatan ini didukung oleh antusias peserta, pangulu dan dana kegiatan. Adapun kendala yang dihadapi adalah para peserta adalah berfikir bahwa bisnis yang sedang dijalankan sudah baik/ berda pada zona nyaman; Tidak mau pusing; Bingung cara memulai mengembangkan usahanya; Tidak melihat adanya potensi lain yang dapat dikelola dan dikembangkan; Tidak memiliki dukungan; Tidak ada mentor dalam bisnis. Manfaat yang dapat diperoleh peserta dari kegiatan pengabdian ini antara lain dapat meningkatkan jumlah pengunjung wisatawan
Stability-Indicating HPLC Method for Quantifying Process-Related Impurities in Fedratinib and Identification of Its Forced Degradation Products Using LC-MS/MS
Authors: Panchadi Gowtham , Uppu Naga Babu , Tatavarti Bhagya Kumar , V.B.V.N. Prasad , Anna Venkateswara Rao 
Published: September 2024

Background: Pharmaceutical industry is characterized by rigorous quality standards to ensure the safety and efficacy of drugs. Despite stringent manufacturing processes, the presence of impurities or generation of degradation products (DPs) in pharmaceutical products remains a concern. This necessitates a comprehensive and systematic approach to analysis impurities and DPs.
Objectives: This study deals with the optimization of the stable HPLC method for quantification of fedratinib impurities and its DPs characterization through LC-MS/MS.
Method: Method optimization studies were conducted by analyzing standard solutions in various method parameters. The results noticed in every varied method condition were tabulated for finalizing the appropriate conditions for analyzing fedratinib. The mass spectral response of DPs was interpreted carefully for structural conformation of DPs.
Results: The method is optimized as HIQSIL C18 (250mm×4.6mm;5µ) column employing 1.0 mL/min flow of phosphate buffer (pH 5.2) and acetonitrile in 45:65 (v/v) and 257 nm. This method elutes 5.4, 2.6, 9.2 and 3.5 min for fedratinib, impurity 1, 2 and 3 respectively. Method sensitivity was verified to be very sensitive that can evaluate up to 0.003, 0.015 and 0.004 µg/mL for impurity 1, 2 and 3 respectively. Well correlated calibration curve achieved in 50-200 µg/mL for fedratinib and 0.05-0.20 µg/mL for impurities. Various stress studies produce four stress DPs and were identified using LC-MS/MS. The molecular mass (g/mol) and formula of DPs were identified as 426 and C21H25N5O3S, 312 and C17H22N5O, 354 and C17H14N4O3S, 215 and C11H11N4O respectively for DP 1 to 4.
Conclusion: The method proposed can successfully be helpful for quantifying the pharmaceutical impurities and DPs of fedratinib in bulk batch samples and formulations.
Evaluation of Beta-cell Regeneration Property of Methanolic Extract of Momordica Dioica in Wistar Rat Model
Authors: Neve Vrushali Neve , Tonape Ashwini , Bhalchim Vrushali , Karwa Pawan , Panbhare Kartik 
Published: September 2024

Background: Despite the existence of various medications for diabetes, many individuals still struggle with the condition due to the potential side effects associated with current treatments. Traditional healers have long relied on medicinal plants with potential antidiabetic properties. One such plant is Momordica dioica, although its traditional use lacks experimental studies to support its efficacy in managing diabetes. Among them, Momordica dioica is one however there are no experimental studies on beta-cell regeneration that support the current traditional uses.
Objective: The main aim of the current research is to identify Momordica dioica's methanolic extract's capacity for beta cell regeneration.
Methods: Air-dried Fruit of Momordica Dioica was extracted using methanol, and acute oral toxicity studies were performed on methanolic extract in accordance with OECD guideline version 18. By using the HPTLC method, the Active Constituent in charge of the activity was verified. The HPTLC method was used to confirm active constituents that were responsible for the activity. The pancreatic beta cell regeneration as well as Fasting blood glucose level was used to evaluate the anti-diabetic effect. Single-dose STZ-induced type 2 diabetes mellitus was used to evaluate anti-antidiabetic activity.
Results: Momordica dioica’s methanolic extract with doses of 100mg/kg and rest combination with standard showed a significant (p < 0.0001) anti-diabetic effect. Maximum anti-diabetic effects at doses as HE100mg/kg and all combinations were compared to standard and observed from Day 21 induction of diabetes by Streptozotocin; total tested doses of the extract inhibited the destruction of beta-cell significantly (p < 0.0001, p < 0.001).
Conclusion: The existence of berberine, a quaternary ammonium salt of the alkaloid benzyl-iso-quinoline present in the extract, had a potential anti-diabetic effect and beta-cell regeneration property which supports the ancient beliefs.
Pengembangan dan Penyuluhan Sistem Pemantau Kelembaban dan pH Tanah Tanaman Padi untuk Petani Desa Sambit
Authors: Nailul Muna  , Darwito Haryadi Amran , Dutono Titon , Arifin Arifin , Syahroni Nanang , Moegiharto Yoedy , Suparno Hari Wahjuningrat , Lestari Paramita Eka Wahyu 
Published: September 2024

Pertanian telah memberikan kontribusi signifikan dalam pertumbuhan ekonomi dan peningkatan pendapatan masyarakat. Namun, perubahan iklim yang ekstrem berdampak pada tingkat kelembaban dan pH tanah, sehingga mempengaruhi produktivitas tanaman padi. Saat ini, petani di Desa Sambit, Kabupaten Ponorogo, Jawa Timur, menghadapi kendala dalam memantau kelembaban dan pH tanah secara efektif. Hal ini mengakibatkan kesulitan bagi petani dalam menyesuaikan penyiraman dan pemberian pupuk sesuai dengan kebutuhan tanaman padi. Berdasarkan permasalahan tersebut, kami bertujuan untuk meningkatkan keterampilan petani dalam mengelola kondisi tanah dengan lebih efektif melalui pengembangan sistem yang memantau kelembaban dan pH tanah secara real-time. Metode kegiatan ini berupa pengembangan dan penyuluhan yang dilakukan melalui beberapa tahapan yang diawali dengan perencanaan yang meliputi wawancara dan survei. Kedua, pembuatan sistem pemantau kelembaban dan pH yang terintegrasi dengan platform Blynk untuk memantau hasil sensor secara real-time. Ketiga, implementasi sistem di lapangan dan terakhir tahap penyuluhan yang mencakup aspek teoritis dan praktis. Hasil dari kegiatan ini yaitu adanya sistem yang dapat membantu petani dalam memantau kelembaban dan pH secara otomatis dan real-time serta kemauan para petani dalam memodernisasi teknologi pertanian untuk mencapai pertanian yang berkelanjutan. Tindak lanjut dari kegiatan ini adalah memonitor respons petani terhadap sistem yang dikembangkan serta memberikan dukungan teknis yang diperlukan agar penggunaan sistem dapat optimal dan berkelanjutan dalam jangka panjang.
Metilfenidato en adultos con TDAH: ¿Qué dicen las últimas guías?
Authors: Barros Díaz Luis Fernando , Rodríguez Ruiz Lina Marcela , Goiter Cortez Jaime Enrique , Tenganan Ascuntar Ana Katherine , Gabriela Álvarez Adriana 
Published: September 2024

El trastorno por déficit de atención/hiperactividad (TDAH) es una enfermedad neuropsiquiátrica con una prevalencia en adultos estimada entre un 3-5%. Clínicamente , en esta población se observan dificultades atencionales y la disfunción ejecutiva se manifiestan por la dificultad para organizarse, planificar tareas, establecer prioridades, estructurar el tiempo y terminar los proyectos o tareas asignadas, es por ello que el diagnóstico se basa en el análisis de estos comportamientos mediante el DSM IV-V. Dentro de las alternativas terapéuticas, el metilfenidato, es un medicamento psicoestimulante aprobado para el tratamiento del trastorno por déficit de atención, su uso es bastante controvertido, debido a la presencia de efectos adversos a largo plazo que desarrollan algunos pacientes, sin embargo , se ha evidenciado que en algunos otros puede tener un impacto positivo a tal punto que sigue siendo la opción terapéutica de primera línea para el manejo de TDAH en el adulto. Por esta razón, en el presente artículo se reconocerá la importancia del metilfenidato como tratamiento del TDAH según las últimas actualizaciones.
Estimates of Sequences with Ultralong and Short CDR3s in the Bovine IgM B Cell Receptor Repertoire Using the Long-read Oxford Nanopore MinION Platform
Authors: Altvater-Hughes Tess E , Hodgins Harold P , Hodgins Douglas C , Gallo Natasha B , Chalmers Gabhan I , Ricker Nicole D , Mallard Bonnie A 
Published: September 2024

Abstract
Cattle produce Abs with an H chain ultralong CDR3 (40–70 aa). These Abs have been shown to have features such as broad neutralization of viruses and are investigated as human therapeutics. A common issue in sequencing the bovine BCR repertoire is the sequence length required to capture variable (V) and isotype gene information. This study aimed to assess the use of Oxford Nanopore Technologies’ MinION platform to perform IgM BCR repertoire sequencing to assess variation in the percentage of ultralong CDR3s among dairy cattle. Blood was collected from nine Holstein heifers. B cells were isolated using magnetic bead–based separation, RNA was extracted, and IgM+ transcripts were amplified using PCR and sequenced using a MinION R10.4 flow cell. The distribution of CDR3 lengths was trimodal, and the percentage of ultralong CDR3s ranged among animals from 2.32 to 20.13% in DNA sequences and 1.56% to 17.02% in productive protein sequences. V segment usage varied significantly among heifers. Segment IGHV1-7, associated with ultralong CDR3s, was used in 5.8–24.2% of sequences; usage was positively correlated with ultralong CDR3 production (r = 0.99, p &lt; 0.01). To our knowledge, this is the first study to sequence the bovine BCR repertoire using Oxford Nanopore Technologies and demonstrates the potential for cost-efficient long-read repertoire sequencing in cattle without assembly. Findings from this study support literature describing the distribution of length and percentage of ultralong CDR3s. Future studies will investigate changes in the bovine BCR repertoire associated with age, antigenic exposure, and genetics.
Sequence Matters: Primary COVID-19 Vaccination after Infection Elicits Similar Anti-spike Antibody Levels, but Stronger Antibody Dependent Cell-mediated Cytotoxicity than Breakthrough Infection
Authors: Holder Kayla A , Ings Danielle P , Fifield Kathleen E , Barnes David A , Barnable Keeley A , Harnum Debbie O A , Russell Rodney S , Grant Michael D 
Published: September 2024

Abstract
Infection before primary vaccination (herein termed “hybrid immunity”) engenders robust humoral immunity and broad Ab-dependent cell-mediated cytotoxicity (ADCC) across SARS-CoV-2 variants. We measured and compared plasma IgG and IgA against Wuhan-Hu-1 and Omicron (B.1.1.529) full-length spike (FLS) and receptor binding domain after three mRNA vaccines encoding Wuhan-Hu-1 spike (S) and after Omicron breakthrough infection. We also measured IgG binding to Wuhan-Hu-1 and Omicron S1, Wuhan-Hu-1 S2 and Wuhan-Hu-1 and Omicron cell-based S. We compared ADCC using human embryonic lung fibroblast (MRC-5) cells expressing Wuhan-Hu-1 or Omicron S. The effect of Omicron breakthrough infection on IgG anti-Wuhan-Hu-1 and Omicron FLS avidity was also considered. Despite Omicron breakthrough infection increasing IgG and IgA against FLS and receptor binding domain to levels similar to those seen with hybrid immunity, there was no boost to ADCC. Preferential recognition of Wuhan-Hu-1 persisted following Omicron breakthrough infection, which increased IgG avidity against Wuhan-Hu-1 FLS. Despite similar total anti-FLS IgG levels following breakthrough infection, 4-fold higher plasma concentrations were required to elicit ADCC comparable to that elicited by hybrid immunity. The greater capacity for hybrid immunity to elicit ADCC was associated with a differential IgG reactivity pattern against S1, S2, and linear determinants throughout FLS. Immunity against SARS-CoV-2 following Omicron breakthrough infection manifests significantly less ADCC capacity than hybrid immunity. Thus, the sequence of antigenic exposure by infection versus vaccination and other factors such as severity of infection affect antiviral functions of humoral immunity in the absence of overt quantitative differences in the humoral response.
Development of food for special dietary uses of diabetes based on oyster mushroom and brown rice
Authors: Kusumastuty Inggita , Sulistyowati Etik , Handayani Dian , Nugroho Fajar Ari , Cempaka Anggun Rindang , Rustiani Agustin , Rakhmadiyah Alfina Putri , Zulkifli Muhamad , Jasmine Hana Raniza , Prakasita Gemma Karnika , Amanda Firza Zahra , Putri Ajeng Rifana 
Published: September 2024

Diabetes patients often struggle to meet their energy requirements, prompting the suggestion of utilizing Food for Special Dietary Uses (FSDU). Previous research has shown the efficacy of oyster mushrooms’ B-glucan in controlling hyperglycemia and insulin resistance. Brown rice, high in magnesium and fiber with a low glycemic index, is known to lower blood glucose levels. Utilizing both ingredients in FSDU may provide products with recommended energy value, nutrient ingredients, and glycemic index. This study aimed to measure the energy, protein, fat, carbohydrate, fiber, glucose, and glycemic index of four mixed formulations of oyster mushrooms and brown rice, along with a control.The study used a true experimental design with a completely randomized research design. The formulations included: P1=9% mixture of moringa and fish flour, P2=10% mixture of carrot and fish flour, F3=11% mixture of moringa and tempeh flour, and F4=12% tempeh flour. The total energy was measured using various methods: adiabatic oxygen bomb calorimeter for energy, Kjeldahl for protein, Soxhlet for fat, by-difference for carbohydrates, AOAC enzymatic-gravimetric for total dietary fiber, anthrone for total sugar, and blood glucose tests at 0, 15, 30, 45, 60, 90, and 120 minutes post-test-food ingestion for glycemic index measurements. Statistical analysis was performed using the One-Way ANOVA and Kruskal-Wallis tests.The research results indicate significant differences in energy, protein, fat, carbohydrates, total sugar, and fiber values among groups (p<0.01). The lowest glycemic index was found in P4 (44.32, medium category). Further analysis indicated that P4 had higher total energy and fat, but lower carbohydrates, total sugar, and glycemic index. According to the Multiple Attribute Zeleny Method, the P4 formula was the best formula for all parameters.The most effective formula, containing brown rice, oyster mushrooms, and tempeh flour (P4), could be a beneficial option for improving the health of individuals with diabetes in the community.
Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer
Authors: Wu Zhi-Jie , Lan Bing , Luo Jian , Ameti Ayniyazi , Wang Hui , Hu Qiong-Yu 
Published: September 2024

BACKGROUND
Identifying patients with peritoneal metastasis (PMs) of colorectal cancer (CRC) who will benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is crucial before surgery. Inflammatory and nutritional indicators play essential roles in cancer development and metastasis.
AIM
To investigate the association of preoperative inflammatory and nutritional markers with prognosis in patients with CRC-PM.
METHODS
We included 133 patients diagnosed with CRC-PM between July 2012 and July 2018. Patients’ demographics, overall survival (OS), and preoperative inflammatory and nutritional markers were evaluated. The Kaplan-Meier method and log-rank test were used to estimate differences.
RESULTS
Of the 133 patients, 94 (70.6%) had normal hemoglobin (Hb) and 54 (40.6%) had a high neutrophil-to-lymphocyte ratio (NLR). The median OS (mOS) was significantly lower for patients with high NLR (7.9 months) than for those with low NLR (25.4 months; P = 0.002). Similarly, patients with normal Hb had a longer mOS (18.5 months) than those with low Hb (6.3 months; P < 0.001). Multivariate analysis identified age, carbohydrate antigen 199 levels, NLR, Hb, and peritoneal cancer index as independent predictors of OS. Based on these findings, a nomogram was constructed, which demonstrated a good capacity for prediction, with a C-index of 0.715 (95% confidence interval: 0.684-0.740). Furthermore, the 1- and 2-year survival calibration plots showed good agreement between predicted and actual OS rates. The areas under the curve for the 1- and 2-year survival predictions of the nomogram were 0.6238 and 0.6234, respectively.
CONCLUSION
High NLR and low Hb were identified as independent predictive risk factors for poor prognosis in patients with CRC-PM. The established nomogram demonstrated high accuracy in predicting OS for patients with CRC-PM, indicating its potential as a valuable prognostic tool for this patient population.