bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bricolage and Identity Work
Authors: Visscher Klaasjan , Heusinkveld Stefan , O'Mahoney Joe 
Published: March 2017

AbstractLévi‐Strauss’ concept of bricolage has been used widely in a variety of management and organizational studies to highlight creative ‘situational tinkering’. Yet, we know little about ‘the bricoleur’ beyond the assumption of a functional agent responding to conditions of resource scarcity or environmental complexity. As such, studies offer limited possibilities in explaining the occurrence of bricolage in the absence of external demands, or much about who the bricoleur is. Drawing on 136 in‐depth interviews with management consultants, this study argues for a richer understanding of bricolage by exploring the identity of the bricoleur. In doing so, the paper achieves three outcomes. First, it uses the original symbolic and cultural insights of bricolage made by Lévi‐Strauss to detail how bricoleur identities are constructed; Second, it highlights how different organizational strategies enable and constrain the pursuit of bricoleur identities; Finally, it emphasizes the bricoleur's status as primarily an aspirational elite identity in the context of consultancy work, in contrast to its usual treatment as a ‘low status’ activity.
Popularizing a Management Accounting Idea: The Case of the Balanced Scorecard
Authors: Cooper David J. , Ezzamel Mahmoud , Qu Sandy Q. 
Published: March 2017

AbstractWe explore how the Balanced Scorecard (BSC), as a management accounting technique, was developed and marketed as a general management practice. Drawing on actor network theory (ANT), we analyze interviews with key actors associated with theBSC, insights gained from attendingBSCtraining workshops, and other documentary evidence to construct a history of theBSC. Our historical analysis offers theoretical tools to understand how the various features of the accounting technique were translated and transformed, that is, shaped and solidified. This translation entailed processes of modification, labelling, framing, and specification of abstract categories and cause‐effect relations. We also examine the networks and associations that both shape the form of theBSCand mobilize the interests of various constituencies around it to produce what can be regarded as a global management technology. Finally, we highlight the strategies and actions used to maintain control of this technique through its continuous reinvention, and, by doing so, we emphasize the idea of strategic agency.
An update on the diagnosis and treatment of dens invaginatus
Authors: Zhu J , Wang X , Fang Y , Von den Hoff JW , Meng L 
Published: March 2017

AbstractDens invaginatus is a malformation with varying anatomical features, posing challenges to treatment. Early and accurate diagnosis plays a significant role in selecting the appropriate treatment. The diagnosis of teeth with a complex root canal system including dens invaginatus has made progress with the application of three‐dimensional imaging techniques in endodontics. Advanced treatment options provide hope for teeth that could not be saved before. This review discusses diagnostic methods and treatment options for teeth with dens invaginatus, and provides guidelines for the management of dens invaginatus cases in clinic. Current as well as traditional diagnostic techniques are summarized. Treatment options including state‐of‐the‐art alternatives are presented for coronal dens invaginatus and radicular dens invaginatus.
The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis
Authors: Hasegawa K. , Mansbach J. M. , Ajami N. J. , Petrosino J. F , Freishtat R. J. , Teach S. J. , Piedra P. A. , Camargo  C. A. 
Published: March 2017

AbstractEmerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1005 infants (age <1 year) hospitalized for bronchiolitis during 2011‐2014, we observed statistically significant interactions between nasopharyngeal airway CCL5 levels and microbiota profiles with regard to the risk of both intensive care use (Pinteraction=.02) and hospital length‐of‐stay ≥3 days (Pinteraction=.03). Among infants with lower CCL5 levels, the Haemophilus‐dominant microbiota profile was associated with a higher risk of intensive care use (OR, 3.20; 95%CI, 1.18‐8.68; P=.02) and hospital length‐of‐stay ≥3 days (OR, 4.14; 95%CI, 2.08‐8.24; P<.001) compared to the Moraxella‐dominant profile. Conversely, among those with higher CCL5 levels, there were no significant associations between the microbiota profiles and these severity outcomes (all P≥.10).
Causes of pain and loss of function in rotator cuff disease: analysis of 1383 cases
Authors: Maher Anthony , Leigh Warren , Brick Matt , Young Simon , Caughey Michael 
Published: March 2017

BackgroundThe New Zealand Rotator Cuff Registry is a multicentre, nationwide prospective study of rotator cuff repairs established in March 2009.MethodsA total of 1383 rotator cuff repairs were included in this study, all with completed baseline Flex‐SF scores, pain scores and standardized operative forms.ResultsIncreasing tear size and tear retraction, over 4 cm, were associated with decreasing Flex‐SF scores but not pain. Tear area (a composite of tear size and retraction) is increased with advancing age, male gender and a traumatic history but not with smoking. Increased pain scores were associated with supraspinatus (SS) single tears, compared to subscapularis tears, and with labral tears. SS/infraspinatus tears had lower Flex‐SF scores compared to subscapularis/SS.ConclusionThis study presents the relationship between baseline function, pain and tear characteristics in symptomatic rotator cuff tears. Increasing tear size and retraction are related to a loss of function but have minimal effect upon pain. Pain generators included labral pathology, and the involvement of SS. The intraoperative appearance of the long head of biceps pathology did not predict baseline pain and function.
Diagnostic accuracy of computed tomography‐guided biopsy in pathological fractures
Authors: Stokes Christopher M. , Elsewaisy Osama , Pang Grant , Slavin John L. , Schlicht Stephen M. , Choong Peter F. M. 
Published: March 2017

BackgroundObtaining a histological diagnosis is essential for appropriate management of pathological fractures. Computed tomography (CT) is an accurate method of obtaining diagnosis for musculoskeletal tumours. We analysed whether diagnostic accuracy was maintained in the evaluation of pathological fractures.MethodsA retrospective review of 101 consecutive patients presenting to our tertiary musculoskeletal tumour centre with pathological fracture was performed. Patients underwent core needle biopsy under CT guidance of pathological fractures diagnosed by plain radiography and either CT or magnetic resonance imaging. The histopathology of the CT‐guided biopsy was compared with the sample obtained from open biopsy or definitive surgery to determine diagnostic accuracy.ResultsThe mean age at diagnosis was 52 ± 20 years (range: 18–85) in a cohort of 46 men and 55 women. Diagnostic accuracy of CT‐guided biopsy was 82.18%. There were 65 malignant and 36 benign tumours with diagnostic accuracy of 86.15% and 80.56%, respectively. The positive predictive value for a malignant tumour was 98.21% whilst it was 93.1% for benign tumours. The femur (53 cases) and humerus (25 cases) were the commonest bones fractured. The most frequent diagnoses were metastasis (20.79%), giant cell tumour (17.82%), osteosarcoma (9.90%) and myeloma (9.90%). There were no complications of CT‐guided biopsy.ConclusionPathological fracture does not confound the diagnosis of musculoskeletal tumours. CT‐guided biopsy is an accurate diagnostic tool in the evaluation of pathological fractures. Final diagnosis and management should be made in the context of appropriate anatomical and functional imaging using a multidisciplinary approach.
Joint Modeling of Zero-Inflated Panel Count and Severity Outcomes
Authors: Juarez-Colunga E. , Silva G. L. , Dean C. B. 
Published: March 2017

Summary
Panel counts are often encountered in longitudinal, such as diary, studies where individuals are followed over time and the number of events occurring in time intervals, or panels, is recorded. This article develops methods for situations where, in addition to the counts of events, a mark, denoting a measure of severity of the events, is recorded. In many situations there is an association between the panel counts and their marks. This is the case for our motivating application that studies the effect of two hormone therapy treatments in reducing counts and severities of vasomotor symptoms in women after hysterectomy/ovariectomy. We model the event counts and their severities jointly through the use of shared random effects. We also compare, through simulation, the power of testing for the treatment effect based on such joint modeling and an alternative scoring approach, which is commonly employed. The scoring approach analyzes the compound outcome of counts times weighted severity. We discuss this approach and quantify challenges which may arise in isolating the treatment effect when such a scoring approach is used. We also show that the power of detecting a treatment effect is higher when using the joint model than analysis using the scoring approach. Inference is performed via Markov chain Monte Carlo methods.
The contribution of parent–child numeracy activities to young Chinese children's mathematical ability
Authors: Huang Qi , Zhang Xiao , Liu Yingyi , Yang Wen , Song Zhanmei 
Published: March 2017

BackgroundA growing body of recent research has shown that parent–child mathematical activities have a strong effect on children's mathematical learning. However, this research was conducted predominantly in Western societies and focused mainly on mothers’ involvement in such activities.AimsThis study aimed to examine both mother–child and father–child numeracy activities in Hong Kong Chinese families and both parents’ unique roles in predicting young Chinese children's mathematics ability.SampleA sample of 104 Hong Kong Chinese children aged approximately 5 years and their mothers and fathers participated in this study.MethodsMothers and fathers independently reported the frequency of their own numeracy activities with their children. Children were assessed individually using two measures of mathematical ability. Hierarchical regression models were used to investigate the contribution of parent–child numeracy activities to children's mathematical ability.ResultsMothers’ participation in number skill activities and fathers’ participation in number game and application activities significantly predicted their children's mathematical performance even after controlling for background variables and children's language ability.ConclusionsThis study extends previous research with a sample of Chinese kindergarten children and shows that parent–child numeracy activities are related to young children's mathematical ability. The findings highlight the important roles that mothers and fathers play in their young children's mathematical learning.
Boundary interaction: Towards developing a mobile technology‐enabled science curriculum to integrate learning in the informal spaces
Authors: Sun Daner , Looi Chee‐Kit 
Published: March 2017

AbstractThis paper explores the crossover between formal learning and learning in informal spaces supported by mobile technology, and proposes design principles for educators to carry out a science curriculum, namely Boundary Activity‐based Science Curriculum (BAbSC). The conceptualization of the boundary object, and the principles of boundary activity as the key elements to fuse the merits of learning in informal spaces with formal learning, are discussed and elaborated. The key elements of BAbSC are further articulated to provide the framework for curriculum design and development from a holistic perspective. The proposed principles and framework will reinforce the theoretical underpinnings of mobile technology‐enabled curriculum design and development, and can be used to guide teachers to implement curriculum in a more principle‐based and structured manner.
Surgical outcomes of percutaneous nephrolithotomy in 3402 patients and results of stone analysis in 1559 patients
Authors: Rizvi Syed Adibul Hasan , Hussain Manzoor , Askari Syed Hassan , Hashmi Altaf , Lal Murli , Zafar Mirza Naqi 
Published: March 2017

ObjectiveTo report our experience of a series of percutaneous nephrolithotomy (PCNL) procedures in a single centre over 18 years in terms of patient and stone characteristics, indications, stone clearance and complications, along with the results of chemical analysis of stones in a subgroup.Patients and MethodsWe retrospectively analysed the outcomes of PCNL in 3402 patients, who underwent the procedure between 1997 and 2014, obtained from a prospectively maintained database. Data analysis included patients’ age and sex, laboratory investigations, imaging, punctured calyx, duration of operation, volume of irrigation fluid, radiation exposure time, blood transfusion, complications and stone‐free status at 1‐month follow‐up. For the present analysis, outcomes in relation to complications and success were divided in two eras, 1997–2005 and 2006–2014, to study the differences.ResultsOf the 3402 patients, 2501 (73.5%) were male and 901 (26.5%) were female, giving a male:female ratio of 2.8:1. Staghorn (partial or complete) calculi were found in 27.5% of patients, while 72.5% had non‐staghorn calculi. Intracorporeal energy sources used for stone fragmentation included ultrasonography in 917 patients (26.9%), pneumatic lithoclast in 1820 (53.5%), holmium laser in 141 (4.1%) and Lithoclast® master in 524 (15.4%). In the majority of patients (97.4%) a 18–22‐F nephrostomy tube was placed after the procedure, while 69 patients (2.03%) underwent tubeless PCNL. The volume of the irrigation fluid used ranged from 7 to 37 L, with a mean of 28.4 L. The stone‐free rate after PCNL in the first era studied was 78%, vs 83.2% in the second era, as assessed by combination of ultrasonography and plain abdominal film of the kidney, ureter and bladder. The complication rate in the first era was 21.3% as compared with 10.3% in the second era, and this difference was statistically significant. Stone analysis showed pure stones in 41% and mixed stones in 58% of patients. The majority of stones consisted of calcium oxalate.ConclusionsThis is the largest series of PCNL reported from any single centre in Pakistan, where there is a high prevalence of stone disease associated with infective and obstructive complications, including renal failure. PCNL as a treatment method offers an economic and effective option in the management of renal stone disease with acceptable stone clearance rates in a resource‐constrained healthcare system.
The TIR/BB‐loop mimetic AS‐1 prevents non‐alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3‐ASC inflammasome activation
Authors: Wang Xiaolu , Gao Yun , Song Juan , Tang Chao , Wang Man , Que Linli , Liu Li , Zhu Guoqing , Chen Qi , Yao Yong , Xu Yong , Li Jiantao , Li Yuehua 
Published: March 2017

Background and PurposeNon‐alcoholic steatohepatitis (NASH) is characterized by excessive intracellular lipid accumulation, inflammation and hepatic insulin resistance. As the incidence of NASH is increasing worldwide, there is an urgent need to find novel interventional approaches. The pro‐inflammatory cytokine IL‐1β, generated and released from Kupffer cells, is considered to initiate the development of NASH. AS‐1, a synthetic low‐molecule mimetic of myeloid differentiation primary response gene 88 (MyD88), disrupts the interaction between the IL‐1 receptor and MyD88. Here, we investigated whether AS‐1 could attenuate the pathogenesis of NASH with an emphasis on hepatic insulin resistance.Experimental ApproachEight‐week‐old db/db mice were fed a control diet or a methionine‐ and choline‐deficient (MCD) diet. AS‐1 (50 mg·kg−1) or vehicle was administered i.p.Key ResultsAS‐1 administration significantly ameliorated NASH as evidenced by alanine aminotransferase levels and CD68 levels in livers of MCD‐fed mice. AS‐1 inhibited the MCD diet‐induced activation of caspase 1 and the NLRP3‐ASC inflammasome, and also reduced the enhanced levels of ROS, malondialdehyde, 3‐nitrotyrosine, NADPH oxidase complex and CYP reductase‐associated cytochrome p450 2E1 (CYP2E1) expression in the liver. In addition, AS‐1 decreased ROS, inflammasome activation and IL‐1β production in free fatty acid‐LPS‐treated Kupffer cells. Finally, pretreatment with AS‐1 significantly ameliorated gluconeogenesis and insulin desensitization induced by IL‐1β, probably by blocking the interaction between MyD88 and the IL‐1 receptor.Conclusions and ImplicationsOur results indicate that AS‐1 can ameliorate NASH and hepatic insulin resistance and could be considered as a potential strategy for the prevention and treatment of NASH.
Is GH dosing optimal in female patients with adult‐onset GH deficiency? An analysis from the NordiNet® International Outcome Study
Authors: Höybye Charlotte , Weber Matthias M. , Pournara Effie , Tønnes Pedersen Birgitte , Biller Beverly M. K. 
Published: March 2017

SummaryObjectiveTo evaluate gender differences in GH dosing, IGF‐I and cardiovascular risk markers in adults with GH deficiency (GHD).DesignNordiNet® International Outcome Study (NCT00960128), a noninterventional, multicentre study, evaluates the long‐term effectiveness and safety of Norditropin® (Novo Nordisk A/S) in the real‐life clinical setting.PatientsNondiabetic patients (n = 252; 41·7% female) with adult‐onset GHD (age ≥20 years at GH start), ≥4 years’ GH therapy and glycosylated haemoglobin (HbA1c) data at baseline and 4 years.MeasurementsEffects of gender (adjusted for baseline age and body mass index [BMI], average GH dose, treatment duration and concomitant medication) on change from baseline to 4 years (∆) in HbA1c, fasting plasma glucose (FPG), IGF‐I, lipids and waist circumference were evaluated.ResultsGH dose (mean [SE]; mg/day) was similar between females (0·22 [0·02]) and males (0·21 [0·01]) at baseline, but higher in females from year 1 (year 4, females, 0·45 [0·03]; males, 0·32 [0·02]). Mean IGF‐I standard deviation score [SDS] was lower in females vs males at each treatment year; more than one‐third of females still had an IGF‐I SDS below 0 at year 4, compared with only 21·8% of men. An adverse lipid profile at baseline remained poor in more females than males at 4 years. Improvement in total cholesterol was significantly associated with gender (P < 0·0001), improving less in females than in males.ConclusionsThese data highlight that, even after 4 years, GH dose is suboptimal in many female patients, which may impact clinical outcomes; therefore, GH titration for women requires further improvement.
Comparative study of magnetic resonance defaecography and evacuation proctography in the evaluation of obstructed defaecation
Authors: Zafar A. , Seretis C. , Feretis M. , Karandikar S. , Williams S. C. , Goldstein M. , Chapman M. 
Published: March 2017

AbstractAimObstructed defaecation syndrome is a common condition of multifactorial aetiology and requires specialized evaluation. Accurate and reproducible pelvic floor imaging is imperative for multidisciplinary decision‐making. Evacuation proctography (EP) and magnetic resonance defaecography (MRD) are the main imaging modalities used to assess dynamic pelvic floor function. The aim of this prospective study was to compare the findings and acceptability of MRD and EP in the same cohort of patients.MethodThis was a prospective comparative study of MRD vs EP in 55 patients with obstructed defaecation syndrome in a single National Health Service Foundation Trust.ResultsFifty‐five patients were recruited and underwent both EP and MRD. Detection rates for rectocoele were similar (82% vs 73%, P = 0.227), but EP revealed a significantly higher number of trapping rectocoeles compared to MRD (75% vs 31%, P < 0.001). EP detected more rectal intussusceptions than MRD (56% vs 35%, P = 0.023). MRD appeared to underestimate the size of the identified rectocoele, although it detected a significant number of anatomical abnormalities in the middle and anterior pelvic compartment not seen on EP (1.8% enterocoele, 9% peritoneocoele and 20% cystocoele). Patients achieved higher rates of expulsion of rectal contrast during EP compared to MRD, but this difference was not significant (76% vs 64% in MRD, P = 0.092). Of the two studies, patients preferred MRD.ConclusionsMRD provides a global assessment of pelvic floor function and anatomical abnormality. MRD is better tolerated by patients but it is not as sensitive as EP in detecting trapping rectocoeles and intussusceptions.
Brain natriuretic peptide and right heart dysfunction after heart transplantation
Authors: Talha Samy , Charloux Anne , Piquard François , Geny Bernard 
Published: March 2017

AbstractHeart transplantation (HT) should normalize cardiac endocrine function, but brain natriuretic peptide (BNP) levels remain elevated after HT, even in the absence of left ventricular hemodynamic disturbance or allograft rejection. Right ventricle (RV) abnormalities are common in HT recipients (HTx), as a result of engraftment process, tricuspid insufficiency, and/or repeated inflammation due to iterative endomyocardial biopsies. RV function follow‐up is vital for patient management as RV dysfunction is a recognized cause of in‐hospital death and is responsible for a worse prognosis. Interestingly, few and controversial data are available concerning the relationship between plasma BNP levels and RV functional impairment in HTx. This suggests that infra‐clinical modifications, such as subtle immune system disorders or hypoxic conditions, might influence BNP expression. Nevertheless, due to other altered circulating molecular forms of BNP, a lack of specificity of BNP assays is described in heart failure patients. This phenomenon could exist in HT population and could explain elevated BNP plasmatic levels despite a normal RV function. In clinical practice, intra‐individual change in BNP over time, rather than absolute BNP values, might be more helpful in detecting right cardiac dysfunction in HTx.