bluuebunny/crossref_metadata_2025_split huggingface dataset:
TESMIN is a Prognostic Biomarker Associated with Immunosuppression and Activated Cell Cycle in Lung Adenocarcinoma
Authors: Yao Zhiyuan , Song Peng , Dong Yanting , Wu Zhe , Kong Weimao , Jiao Wenjie 
Published: September 2024

Background:
The Testis Expressed Metallothionein Like Protein (TESMIN)
gene encodes highly conserved, cysteine-rich, low-molecular proteins that are activated
by and have an affinity for heavy metal ions. Previous literature has shown its association
with cancer. Nevertheless, no thorough bioinformatics analysis of TESMIN has
been done yet in lung adenocarcinoma (LUAD).

Methods:
Differential expression of TESMIN between cancer and normal tissues was
confirmed by analyzing databases and immunohistochemistry staining. Enrichment analysis
was adopted to explore biological functions. The relationship of TESMIN with immune
infiltration was evaluated by ssGSVA, with immunotherapy response predicted by
TCIA and TIDE tools, with mutational traits analyzed by R software. Drug sensitivity
analysis was implemented via GSCA tool, pRRophetic algorithms, and CellMiner
database.

Results:
The results demonstrated that TESMIN expression was upregulated in tumor tissue
and related to Ki67. TESMIN was associated with poor survival and significantly related
to age, gender, N stage, M stage, pathological stage, and survival status. TESMIN-
related genes (TRGs) were primarily involved in cell division and cancer-related
enrichment pathways. TESMIN was associated with high frequencies of somatic mutations
and an immunosuppressive tumor microenvironment. Interestingly, patients with elevated
levels of TESMIN expression benefited more from commonly used chemotherapy
drugs such as cisplatin, paclitaxel, vinorelbine, and docetaxel, whereas those with
low levels of TESMIN expression showed favorable clinical responses to immunotherapy.

Conclusion:
As a prognostic biomarker associated with the cell cycle and immune infiltration,
TESMIN may serve as an effective target for predicting the sensitivity to immunotherapy
and chemotherapy.
Zuogui Pills Improve the Learning and Memory Ability of Brain-Aging Mice through the Estrogen Receptor ERα Methylation Pathway
Authors: Huang Yang , Zhong Lili , Yang Jing , Dai Qiaomei , Zhao Li , Zhang Mengdi , Liu Hong 
Published: September 2024

Introduction:
Sex hormones are important factors in maintaining brain function and
acting as brain protectors. Recent research suggests that neuronal damage in brain aging may be
linked to the methylation of the estrogen receptor α (ERα). However, the mechanism of Zuogui
Pills (ZGW) in brain-aging ERα DNA methylation and neuronal repair remains unknown.

Materials and Methods:
D-galactose-induced ovary removal mice were used as a model of aging.
Changes in estrous cycle were detected in mice by vaginal cell smear. Animal behavior
tests, including the Morris water maze (MWM) and new object recognition (NOR) test, were
conducted. Hematoxylin-eosin (HE) and Nissl-staining were carried out to assess hippocampal
neurogenesis. Enzyme-linked immunosorbent assay (ELISA) was performed for 5-
methylcytosine methylation levels, and immunohistochemistry (IHC) and western blotting (WB)
experiments were performed to assess ERα/DNA methyltransferase 1 (DNMT1) expression after
ZGW treatment. Finally, bisulfite sequencing PCR (BSP) analysis was performed to identify
methylated differentially expressed estrogen receptor 1 (ESR1) gene in D-gal-induced senescent
neurons before and after ZGW treatment.

Results:
We found that ERα methylation was involved in the delayed brain ageing process of
ZGW. Mechanistically, ZGW can improve the learning and memory ability of brain-aging mice,
reduce the expression of 5-methylcytosine (5-mc) in serum, increase the amount of ERα, inhibit
the expression of DNMT1, and significantly reduce methylated expression of the ESRI gene.

Conclusion:
Our data suggested that ZGW slowed down D-gal-induced brain aging in mice, and
these results showed that ZGW is beneficial for aging. It may be used for neuronal protection in
aging.
Latent Fingermarks Analysis by Imaging Mass Spectrometry
Authors: González Marina , Araujo dos Santos Nayara , Medeiros de Almeida Camila , Ortiz Rafael Scorsatto , Limberger Renata Pereira , Romão Wanderson , de Cássia Mariotti Kristiane , Mendez Andreas Sebastian Loureiro 
Published: September 2024

Background:
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
(MALDI-MSI) technique has been reported in the literature for fingermark analysis and forensic
purposes. One of the greatest challenges in this field involves the aging of fingermarks, which has an
essential role in criminal investigation.

Objective:
This study presents an approach to preservation fingermarks analysis through the MALDI-
Fourier transform ion cyclotron resonance mass spectrometry method, comparing different matrix
samples.

Methods:
For MALDI analysis, the efficiency of three MALDI matrices (α-cyano-4-
hydroxycinnamic acid (CHCA), 2-mercaptobenzothiazole (MBT), and 2,5-dihydroxybenzoic acid
(DHB)) in the ionization process of monitored analytes (m/z 368.4, m/z 522.6 and m/z 550.6) was
initially evaluated, along with the spatial resolution (80 × 80 μm and 100 × 100 μm).

Results:
The CHCA matrix, and the resolution of 100 × 100 μm were chosen for the MALDI MSI
analysis. The fingermark collections were analyzed at eight intervals from zero hours to fifty days.
Additionally, photochemical aging (from zero hours to five days) of fingermarks, performed by applying
constant light for five days to three different samples from the same donor, resulted in loss of
chemical material and deformation of the image obtained by MALDI FT-ICR MSI analysis. On the
other hand, in natural aging, the most expressive result showed that it is possible to visualize fingermark
ridges of up to fifty days elapsed.

Conclusion:
The method proposed showed a potential for fingermark examination and application in
forensic routine. Chemical imaging of fingermarks can be a useful tool in detecting and comparing
evidence, even after a considerable period.
Digital Mental Health Interventions for Adolescents in Low- and Middle-Income Countries: Scoping Review
Authors: Wani Carolina , McCann Lisa , Lennon Marilyn , Radu Caterina 
Published: September 2024

Background
Digital mental health interventions (DMHIs) are increasingly recognized as potential solutions for adolescent mental health, particularly in low- and middle-income countries (LMICs). The United Nations’ Sustainable Development Goals and universal health coverage are instrumental tools for achieving mental health for all. Within this context, understanding the design, evaluation, as well as the barriers and facilitators impacting adolescent engagement with mental health care through DMHIs is essential.

Objective
This scoping review aims to provide insights into the current landscape of DMHIs for adolescents in LMICs.

Methods
The Joanna Briggs Institute scoping review methodology was used, following the recommendations of the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews). Our search strategy incorporated 3 key concepts: population "adolescents," concept "digital mental health interventions," and context "LMICs." We adapted this strategy for various databases, including ACM Digital Library, APA PsycINFO, Cochrane Library, Google Scholar (including gray literature), IEEE Xplore, ProQuest, PubMed (NLM), ScienceDirect, Scopus, and Web of Science. The articles were screened against a specific eligibility criterion from January 2019 to March 2024.

Results
We analyzed 20 papers focusing on DMHIs for various mental health conditions among adolescents, such as depression, well-being, anxiety, stigma, self-harm, and suicide ideation. These interventions were delivered in diverse formats, including group delivery and self-guided interventions, with support from mental health professionals or involving lay professionals. The study designs and evaluation encompassed a range of methodologies, including randomized controlled trials, mixed methods studies, and feasibility studies.

Conclusions
While there have been notable advancements in DMHIs for adolescents in LMICs, the research base remains limited. Significant knowledge gaps persist regarding the long-term clinical benefits, the maturity and readiness of LMIC digital infrastructure, cultural appropriateness, and cost-effectiveness across the heterogeneous LMIC settings. Addressing these gaps necessitates large-scale, co-designed, and culturally sensitive DMHI trials. Future work should address this.
Key Forensic Accounting Takeaways: People Ex Rel. James v. Donald J. Trump et al.
Authors: Tinkelman Daniel 
Published: September 2024

ABSTRACT
On February 16, 2024, a New York court found former President Trump and others civilly liable, under a specific New York law, for up to $450 million, including interest, for providing misleading financial statements to banks and others. I explain the legal basis of the suit, which is very different from common law fraud suits. It was brought by the New York State Attorney General, not the purported victims. There are sharply divergent views on whether the suit should have been brought. I also discuss five other issues of interest to forensic accountants pertinent to the trial: the use of “estimated current value” in personal financial statements; differing views of materiality; the protective value of disclaimers for financial statement issuers and accountants performing compilations; the impact of deferred tax liabilities to net worth; and whether personal financial statements have value.
Data Availability: Data are available from public sources cited in the text.
JEL Classifications: M41; M42; M49.
National Seismological Bulletin of Ukraine in 2022
Authors: Andrushchenko Yu.A. , Liashchuk O.I. , Farfuliak L.V. , Amashukeli T.A. , Ganiev O.Z. , Osadchyi V.I. , Petrenko K.V. 
Published: September 2024

As of 2022, the National System of Seismic Observations of Ukraine had a network of observation points run by the S.I. Subbotin Institute of Geophysics of the National Academy of Sciences and the Main Center for Special Control of the State Space Agency of Ukraine. These institutions established a unified National Data Center, where the data is collected, processed, and analyzed. Information is provided both in real time and later, after an in-depth analysis, in the form of seismological bulletins and earthquake catalogs.
According to the observations, 160 earthquakes occurred on the territory of Ukraine and neighboring countries in 2022. Most were confined to the deep focus Vrancea zone (Romania). The maximum recorded earthquake magnitude is 5.4. Earthquakes from the territory of other neighboring states had a local character and did not significantly impact the seismicity of Ukraine’s territory. The most powerful earthquakes within the territory of Ukraine were registered in the Poltava region on July 6, 2022, and October 3, 2022. These earthquakes had a magnitude of 3.4 and a hypocenter depth of 10 km and caused shaking in the epicentral region with an intensity of up to 2 points. In addition, on January 21, 2022, there was an earthquake in the Kryvyi Rih region. This earthquake had a magnitude of 3.3, but due to the smaller depth of the hypocenter (h=5 km), it caused perceptible tremors in the area of the epicenter with an intensity of up to 3 points.
On the territory of Ukraine, most of the epicenters of registered earthquakes are located within Volyn-Podillia, the Dnieper-Donets Depression, and the Transcarpathian Depression.
The seismological bulletin of Ukraine includes detailed information on all seismic events that occurred in 2022 in the territories of Ukraine and neighboring countries.
Full information on each earthquake from the Earthquake Catalog for 2022 is provided in full in the pdf file of the article of the same name on the website of the Geophysical Journal.
Nanofibrous membranes loaded with bupivacaine and carica papaya extract for pain management and wound healing in postoperative wounds
Authors: Zhang Aiqin , Hussain Shaik Althaf , Alrubie Turki Mayudh , Jiang Rong 
Published: September 2024

Abstract
The pursuit of effective pain management and wound healing strategies within modern medicine remains a challenge. Postoperative skin injuries arising from surgeries and traumatic incidents often bring substantial discomfort, necessitating interventions that combine optimal pain relief with accelerated wound recovery. In this research, bupivacaine and carica papaya extract were loaded into polycaprolactone/polyvinyl alcohol membranes in order to develop a pain-relieving wound dressing material for pain management and skin wound healing after surgeries. The in vitro experiments were used to characterize the pain-relieving scaffold. An in vivo study of the excisional wound was carried out in a rat model. Histopathological examinations, wound closure studies, and pain-related behavioral factors were utilized to assess the in vivo pain management and wound healing efficacy of the dressings. Results showed that our developed constructs were not toxic and modulated inflammatory responses. In vivo study showed that this system could successfully close wounds and decrease the sensitivity of animals to painful stimuli. These wound dressings may potentially be considered dual function wound dressings to treat skin injuries.
Relationship Between Land Use and Occupation and Water Quality in The Lagoon of Extremoz – RN
Authors: Silva Luana Lee Lima da , Virginia Ceres Dantas , Torres Dayana Melo , Araújo André Luis Calado , Melo Luis Eduardo Lima de 
Published: September 2024

Objective: The objective of this study was to relate the quality of water in the Extremoz/RN lagoon, over the period 2018 to 2021, with the evolution of the use and occupation of the surrounding land.

Theoretical Reference: In this topic, the theoretical input used to discuss the data, such as the availability of water according to the National Agency for Water and Basic Sanitation (ANA), the National Water Resources Policy, the GM/SM Ordinance No. 888 of 2021, and the information on the Trophic State Index (IET) is discussed.

Method: This research was characterized as exploratory, descriptive and explanatory, being carried out through bibliographic, documentary, experimental and field research. Based on data provided by CAERN on water quality, and maps drawn up to analyze land use and occupation using Google Earth and Qgis tools, it was possible to relate how the use and occupation of the lagoon's margins had an influence on water quality.
Results and Discussion: It was found that there is a direct correlation between the concentrations of cyanobacteria, determined by CAERN in the water of the Lagoon, and the Trophic State Index, measured by IGARN (Institute of Water Management of the State of Rio Grande do Norte). The Extremoz Water Treatment Plant must pay attention to these results, identifying whether the treatment adopted is managing to eliminate the cyanobacteria to supply for human supply within the required standards of potability, due to the high concentrations of these organisms affecting human health.

Research Implications: This study allowed us to analyze the water quality of a surface water supply, as well as the consequences of the use and occupation of the soil on the banks of the said source. In this way, the work is contributing towards possible analyzes of how to improve the management and monitoring of the surface water sources.

Originality/Value: The study has relevance and importance for the population to know the water quality of the source used for the supply, as well as for the management of the municipality to identify ways to improve ecological-environmental zoning of the locality, and to guarantee the sustainability and quality of the waters of the spring.
The Fragility Index of Risk Factors for Hamstring Injuries
Authors: Anthis Matthew , Gourd Stephanie , Kim Brian , Ruddy Joshua D. , Whiteley Rod , Timmins Ryan , Maniar Nirav , Hickey Jack , Opar David A. 
Published: September 2024

OBJECTIVE: To determine the Fragility Index of hamstring injury risk factors, defined as the minimum number of participants who would need to change classification to make a hamstring injury risk factor statistically nonsignificant. DESIGN: Retrospective secondary data analysis. METHODS: Studies that investigated 1 or more risk factors for hamstring injury, and presented sufficient data to develop a 2 × 2 contingency table were included. A systematic literature search and reference screening of a recent hamstring injury systematic review were conducted to identify 78 articles. Relative risk and 95% confidence intervals were determined and then systematically recalculated by removing 1 observation from the high-risk injury count and adding it to the high-risk noninjury count. The Fragility Index for a risk factor was the number of observations required to be moved between groups until the relative risk was no longer significant. RESULTS: The median Fragility Index of all hamstring injury risk factors was 3 (Q1-Q3 = 2-6). The Fragility Index for nonmodifiable risk factors was 3 (Q1-Q3 = 2-6) and 3 (Q1-Q3 = 2-5) for modifiable risk factors. Over 35% of all included hamstring injury risk factors had a Fragility Index of ≤2. CONCLUSION: Most statistically significant hamstring injury risk factors are fragile associations. The interpretation of significant hamstring injury risk factors should consider a range of statistical metrics, and while the Fragility Index should never be considered in isolation, it is an intuitive measure to help assess the robustness of findings. J Orthop Sports Phys Ther 2024;54(10):672-678. Epub 4 September 2024. doi:10.2519/jospt.2024.12300
STATE-OF-THE-ART AND DEVELOPMENT TRENDS OF GEOGRAPHIC INFORMATION SYSTEMS
Authors: Алчинов А.И. , Гороховский И.Н. , Акифьева Е.В. 
Published: September 2024

Поддержка принятия решений при управлении сложными организационными и техническими системами сохраняет свою актуальность в связи с растущей ролью и возможностями географических информационных систем, которые и являются объектом настоящего исследования. Анализируется уровень их представления в мировой и российской среде, особенности их развития, а также основные научные результаты, полученные в Институте проблем управления им. В. А. Трапезникова РАН. Выделены самые востребованные в сфере хозяйствования технологии и функциональные возможности геоинформационных систем. Геоинформационная система рассмотрена как инструмент обработки и поддержки принятия управленческих решений. Исследованы основные зарубежные и российские геоинформационные системы, основные их характеристики, области применения, тенденции и перспективы развития. Приведены описания геоинформационных технологий и алгоритмов, реализованных в полнофункциональных геоинформационных системах и рассматриваемых как платформы для создания геоинформационных систем различного назначения.
When managing complex organizational and technical systems, decision support remains relevant due to the growing role and capabilities of geographic information systems (GISs). This survey is devoted to GISs. We analyze the level of their representation in the world and Russian environment, the peculiarities of their development, and the main related results obtained at the Trapeznikov Institute of Control Sciences, the Russian Academy of Sciences. We highlight the technologies and functionality of GISs that are of high demand in the field of management. A GIS is interpreted as a mechanism to process and support managerial decisions. The main foreign and Russian GISs are overviewed, including their main characteristics, applications, and development trends. We describe geoinformation technologies and algorithms implemented in full-fledged GISs and also those providing platforms for creating various-purpose GISs.
Introduction study of species of the family Ericaceae Juss. in the collection of the Cheboksary Branch of the Main Botanical Garden RAS
Authors: Балясная Л.И. , Прокопьева Н.Н. , Самохвалов К.В. 
Published: September 2024

Представлены результаты комплексных исследований по интродукции видов семейства Ericaceae Juss. Целью исследований являлось создание, расширение и сохранение коллекции этих видов для поддержания биологического разнообразия, изучение их биоэкологических особенностей и адаптационных возможностей, оценка перспективности интродукции в условиях Чувашии и возможности их применения для целей озеленения. Дан список видов, вариантов и сортов родов Calluna Salisb., Erica L., Enkianthus Lour., Rhododendron L., Vaccinium L., сохраняемых в Чебоксарском ботаническом саду в условиях открытого грунта. Приведены биометрические данные наблюдаемых растений, фенология развития, способы размножения и зимостойкость, особенности агротехники с учетом почвенно-климатических условий региона и эколого-биологических особенностей растений.
The article presents results of complex studies on the introduction of species of the family Ericaceae Juss are presented. The purpose of the research was to create, expand and preserve a collection of these species to maintain biological diversity, study their bioecological features and adaptive capabilities, assess the prospects for introduction in Chuvashia and the possibility of their use for landscaping purposes. The list of species, variants and varieties of the genera Calluna Salisb., Erica L., Enkianthus Lour., Rhododendron L., Vaccinium L. preserved in the Cheboksary Botanical Garden in open ground conditions are given. The year of the introduction to the collection, the feel of original material, the average height and average crown diameter of the plants, the achieved phase of development, methods of propagation and hardiness, agro-technical measures for the conservation of exotic species in the collection with consideration of soil-climatic conditions of the region and ecological-biological features of these plants are stored.
INTELLIGENT CONTROL SYSTEMS FOR UNMANNED AERIAL VEHICLES
Authors: БАБИЧЕНКО А.В. , СЕЛЕЗНЕВА М.С. , ПРОЛЕТАРСКАЯ В.А. , НЕУСЫПИН К.А. , ПРОЛЕТАРСКИЙ А.В. 
Published: September 2024

Рассмотрены современные системы управления беспилотными летательными аппаратами. Представлены система управления с интеллектуальной компонентой и интеллектуальная система управления, которая основана на теории функциональных систем П.К. Анохина. При решении сетецентрических задач интеллектуальные системы беспилотных летательных аппаратов должны обладать богатой базой данных и механизмом быстрой обработки огромного объема данных. Для этого при реализации запросов к базе данных используется платформа параллельной обработки данных Spark 2 на основе каскадного применения фильтра Блума. Выполнено сравнение двух методов доступа к хранилищу данных: разработанного метода с каскадным использованием фильтра Блума и встроенного Hive. Проведены натурные эксперименты в среде кластера из 8 узлов на платформе распределённых параллельных вычислений Apache Spark 2. Результаты экспериментов подтвердили преимущества разработанного метода обработки больших данных.
Modern control systems for unmanned aerial vehicles are considered. A control system with an intellectual component and an intelligent control system are presented, which is based on the theory of functional systems of PK Anokhin. In solving network-centric problems, intelligent systems of unmanned aerial vehicles must possess a rich database and a mechanism for rapidly processing huge amounts of data. Therefore, when implementing queries to the database, the parallel processing platform Spark 2 is used, based on the cascaded application of the Bloom fi lter. Comparison of two methods of access to the data store is made: the developed method with cascading Bloom fi lter and built-in Hive. The experiments were conducted in a cluster environment of 8 nodes on the platform of distributed parallel computations of Apache Spark 2. The results of the experiments confirmed the advantages of the developed method for processing large data.