bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a virtual reality serious game for experiencing the colors of Dunhuang frescoes
Authors: Liu Zhizheng , Chen Ding , Zhang Chi , Yao Jian 
Published: October 2024

Abstract
With the rapid advancement of digital games, serious games have emerged as a significant medium for engaging with cultural heritage. As a primary visual element in cultural heritage, color plays a crucial role in users’ digital learning. However, there is currently a scarcity of serious game designs that specifically focus on cultural heritage colors, indicating potential for improvement in the user experience. To further enhance users’ perception of color and create a more engaging and enriching digital cultural heritage experience, this study proposes a virtual reality serious game (VR SG) design method specifically tailored to cultural heritage colors. Additionally, it explores the potential of VR SG in enhancing the education, entertainment, and dissemination aspects of these colors within cultural heritage. Specifically, we explore how to integrate relevant knowledge of cultural heritage colors into the application process of VR SG and assess users’ learning performance, engagement, and interactive willingness within these VR SG. The study employs the colors of the Dunhuang cave frescoes as a case study for design practice. A total of 30 participants took part in a between-group comparison experiment, utilizing a mixed-methods approach that combined quantitative and qualitative assessments to compare the performance of a VR SG with a VR exhibition game. The results indicate that both the VR SG and the VR exhibition game effectively enhance users’ understanding and retention of knowledge, with VR SG users demonstrating higher levels of task engagement, emotional engagement, willingness to explore, and willingness to share. This study confirms the potential of VR SG to enhance the education, entertainment, and dissemination aspects of cultural heritage colors and discusses the implications of VR SG in supporting digital cultural heritage experiences.
Gastrointestinal stromal tumor in Carney’s triad with laparoscopic total gastrectomy: a case report
Authors: Midoritani Hajime , Kawada Hironori , Kaneda Kosuke , Toda Shuichiro , Awane Kento , Tanino Keisuke , Harada Kaichiro , Tachibana Keigo , Honjo Masahiko , Kitamura Koji , Yoshitomi Mami , Shirakata Yoshiharu , Nishitai Ryuta 
Published: October 2024

Abstract
Introduction
Carney's triad is a rare syndrome characterized by the co-occurrence of gastric gastrointestinal stromal tumor (GIST), pulmonary chondroma, and extra-adrenal paraganglioma. We present a case of a young woman with GISTs associated with this triad.

Case presentation
A 28-year-old woman was identified with multiple gastric tumors and a right lung nodule during a routine health check-up. CT scans and upper gastrointestinal endoscopy revealed a 50 mm mass on the lesser curvature of the stomach, along with two additional gastric lesions and a 20 mm nodule in the right lung. The patient had a history of right middle lobectomy at the age of 19 for pulmonary chondroma. During surgery, enlarged lymph nodes were observed, indicating metastasis, which necessitated a total gastrectomy with radical (D2) lymph node dissection. Pathological examination confirmed seven GISTs, with immunohistochemical staining positive for KIT (+), DOG1 (+), and negative for SDHB (−). The postoperative course was uneventful, and the patient was discharged on the seventh postoperative day. Despite opting out of adjuvant imatinib therapy, she remains disease-free 2 years postoperatively.

Conclusions
This case underscores the necessity of total gastrectomy with lymph node dissection due to the high incidence of metastasis in GISTs associated with Carney's triad. Further research is required to determine the optimal extent of lymph node dissection in such cases.
Comparative study on predicting turbulent kinetic energy budget using high-order upwind scheme and non-dissipative central scheme
Authors: Wang Dandi , Du Yiming , Jin Yao , Cai Jinsheng , Liao Fei 
Published: October 2024

AbstractThe accurate computation of different turbulent statistics poses different requirements on numerical methods. In this paper, we investigate the capabilities of two representative numerical schemes in predicting mean velocities, Reynolds stress and budget of turbulent kinetic energy (TKE) in low Mach number flows. With concerns on numerical order of accuracy, dissipation and dispersion properties, a high-order upwind scheme with relatively good dispersion and dissipation and a second-order non-dissipative central scheme with perfect dissipation but poor dispersion are adopted for this comparative study. By carrying out a series of numerical simulations including Taylor-Green vortex, turbulent channel flow at $$Re_{\tau }=180$$

R

e
τ

=
180

and turbulent flow over periodic hill at $$Re_{b}=10595$$

R

e
b

=
10595

, it can be obtained that although the high-order upwind scheme lacks perfection of dissipation in high wave number range, it still demonstrates superior predictive capability compared with the second-order non-dissipative central scheme, especially with relatively coarse grids. Finally, by taking the high-order upwind scheme as a suitable selection for turbulence simulation, the turbulent flow over a 30P30N multi-element airfoil is investigated as an application study. After briefly comparing the simulated profiles and spectrum with reference experimental results as validation, the budget of TKE is analyzed to locate the dominant flow structures and regions. It is found that the production and dissipation terms behave in a “monopole” pattern in the locations with strong shears and wakes. Whereas the advection and diffusion terms show an “inward” pattern and an “outward” pattern, which indicate the spatial transport of TKE between the center of the shear layer and nearby locations.
Hepatic toxicity assessment in HIV’s interaction with reverse transcriptase and integrase strand transfer inhibitors at a military hospital, southsouth Nigeria
Authors: Odegbemi Odekunle Bola , Olaniyan Mathew Folaranmi , Muhibi Musa Abidemi 
Published: October 2024

Abstract
Introduction
The use of anti-retroviral therapy (ART) has made HIV a manageable condition, but there are risks associated with medications like reverse transcriptase inhibitors (RTIs) and integrase strand transfer inhibitors (INSTIs), such as liver and renal toxicity. It is essential to understand these risks for effective treatment and case management. Investigating liver toxicity related to RTIs and INSTIs in Nigeria is crucial for optimizing HIV treatment. This study aimed to assess the impact of tenofovir lamivudine dolutegravir (TLD) on the liver function of HIV patients at Nigerian Navy Hospital (NNH)-Warri.

Methods
The liver function of 170 participants was assessed, with 120 on ART and the remainder being HIV-negative attendees at NNH-Warri. The study used a cross-sectional design and selected participants through random sampling. We collected data using a semi-structured questionnaire. Blood samples were taken through venipuncture and stored at – 20 °C before analysis. Ethical approval was obtained, and data analysis was conducted using SPSS Statistical Software Version 23, with significance set at p < 0.05.

Results
The study found significant differences in AST, TP, Alb, and GST levels between HIV-positive subjects receiving TLD and HIV-negative individuals. HIV-positive subjects had lower AST and Alb levels but higher TP and GST levels. Further analysis revealed correlations between age, gender, and liver enzymes, highlighting the complex relationship between HIV, liver function, and treatment outcomes.

Conclusion
The study suggests that decreased AST levels may have a protective effect, while ALT activity had minimal impact. Changes in TP, Alb, and GSTs emphasize the importance of monitoring hepatic synthetic function and detoxification pathways in HIV patients taking TLD.
Efficient equivalent-layer technique for processing irregularly spaced magnetic data on uneven surfaces
Authors: Piauilino Larissa S. , Oliveira Vanderlei C. , Barbosa Valéria C. F. 
Published: October 2024

We develop a new rapid and robust equivalent-layer method for processing large magnetic data sets that can deal with irregularly spaced data points on undulating surfaces. Our method estimates an equivalent layer by numerically solving the upward continuation integral for a given set of magnetic data. Although this estimated layer allows performing specific spatial transformations, such as interpolation and continuations of any potential-field data, it cannot be used to perform conventional phase transformations on magnetic data, such as the reduction to the pole, because this layer requires a magnetic moment distribution over the equivalent layer of dipoles. To overcome this drawback, we transform the estimated equivalent layer into a planar equivalent layer of dipoles that equally reproduces the observed magnetic data. To carry out this transformation, we first use the fact that the estimated layer obtained by solving the upward continuation integral is a scaled version of the magnetic data on the layer plane, i.e., it can be considered a harmonic function. Then, we use the upward continuation integral to continue the estimated layer into a planar and regular grid, which results in a second equivalent layer. Finally, we apply a fast 2D discrete convolution to transform this second layer into a planar equivalent layer of dipoles that also fits the observed magnetic data. Applications to synthetic and real data show that our methodology is able to efficiently process magnetic data, combining the robustness of accommodating irregularly spaced data with the ability to perform phase transformations.
Population-Based Study of Rare Coding Variants in NR5A1/SF-1
Authors: Kouri Chrysanthi , Jia Raina Y , Kentistou Katherine A , Gardner Eugene J , Perry John R B , Flück Christa E , Ong Ken K 
Published: October 2024

Abstract

Background
Steroidogenic Factor 1/Nuclear Receptor Subfamily 5 Group A Member 1 (SF-1/NR5A1) is critical for the development and function of sex organs, influencing steroidogenesis and reproduction. While rare deleterious NR5A1/SF-1 variants have been identified in individuals with various differences of sex development (DSD), primary ovarian insufficiency, and infertility, their impact on the general population remains unclear.

Methods
We analyzed health records and exome sequencing data from up to 420 162 individuals (227 858 women) from the UK Biobank study to assess the impact of rare (frequency &lt; 0.1%) predicted deleterious NR5A1/SF-1 variants on age at menopause and 26 other traits.

Results
No carriers of rare protein truncating variants in NR5A1/SF-1 were identified. We found that the previously reported association of rare deleterious missense NR5A1/SF-1 variants with earlier age at menopause is driven by variants in the DNA binding domain (DBD) and ligand binding domain (LBD) (combined test: beta = −2.36 years/allele, [95% CI: 3.21, −1.51], N = 107 carriers, P = 4.6 × 10−8). Carriers also had a higher risk of adult obesity (OR = 1.061, [95% CI: 1.003, 1.104], N = 344, P = .015), particularly among women (OR = 1.095 [95% CI: 1.034, 1.163, P = 3.87 × 10−3], N = 176), but not men (OR = 1.019, [95% CI: 0.955, 1.088], P = .57, N = 168).

Conclusion
Deleterious missense variants in the DBD and LBD likely disrupt NR5A1/SF-1 function. This study broadens the relevance of deleterious NR5A1/SF-1 variants beyond rare DSDs, suggesting the need for extended phenotyping and monitoring of affected individuals.
Imaging interorganelle contacts at a glance
Authors: Zanellati Maria Clara , Hsu Chih-Hsuan , Cohen Sarah 
Published: October 2024

ABSTRACT
Eukaryotic cells are compartmentalized into membrane-bound organelles that must coordinate their responses to stimuli. One way that organelles communicate is via membrane contact sites (MCSs), sites of close apposition between organelles used for the exchange of ions, lipids and information. In this Cell Science at a Glance article and the accompanying poster, we describe an explosion of new methods that have led to exciting progress in this area and discuss key examples of how these methods have advanced our understanding of MCSs. We discuss how diffraction-limited and super-resolution fluorescence imaging approaches have provided important insight into the biology of interorganelle communication. We also describe how the development of multiple proximity-based methods has enabled the detection of MCSs with high accuracy and precision. Finally, we assess how recent advances in electron microscopy (EM), considered the gold standard for detecting MCSs, have allowed the visualization of MCSs and associated proteins in 3D at ever greater resolution.
Przemiany w strukturze konsumpcji w państwach europejskich w świetle koncepcji zrównoważonego rozwoju
Authors: Jankiewicz Mateusz 
Published: October 2024

Przemiany w strukturze konsumpcji w państwach europejskich w świetle koncepcji zrównoważonego rozwoju (Changes in the structure of consumption in European countries in light of the concept of sustainable development) is a study of a theoretical and empirical character. The publication concerns important and up-to-date economic problems such as consumption and sustainable development, focusing on the relationship between changes taking place in the structure of household consumption expenditure and changes in the sustainable development of selected countries in Europe. An important element of this book is the indication of the importance of interactions between neighbouring countries (at the geographical and economic level) in the study of the above-mentioned relationship, as well as the need to include spatial connections in the analysis of changes in the consumption structure and their impact on sustainable development, which is possible thanks to the use of tools of modern spatial statistics and econometrics. The publication may be of interest to scientific researchers, analysts who study the relationship between economic processes and their forecasting, as well as students of economics and geography (mainly socio-economic geography).
"Japonesa, abre o olho”: racismo, xenofobia e misoginia contra mulheres amarelas
Authors: Kurihara Julia Tiemi , Baliscei João Paulo 
Published: October 2024

Este artigo tematiza as diversas manifestações de ódio que acometem as mulheres amarelas. Assim, o objetivo desta pesquisa é problematizar as violências xenofóbicas, racistas e misóginas que, na contemporaneidade, atingem as identidades femininas nipônicas. Para isso, recorre-se aos Estudos da Cultura Visual como aporte teórico e metodológico, uma vez que considera que as imagens, em suas diversas manifestações, apresentam formas de se ver e estar no mundo. A partir da pesquisa bibliográfica, foi realizada a contextualização histórica, cultural e social da chegada das/os imigrantes japonesas/es no Brasil. Em seguida, foi feita uma análise de discursos, obras de arte e outras visualidades que permeiam os significados estereotipados construídos acerca das identidades de mulheres amarelas, em especial no contexto da pandemia do COVID-19. Por fim, conclui-se que a educação possui potencial para construir novas narrativas que rompam preconceitos e respeitem as diferenças, uma vez que a sociedade contemporânea é composta por múltiplas identidades que interagem entre si.
Use of spectral transmittance model to improve the detection accuracy of chromium in soil
Authors: Yao Mingyin , Wan Qi , Liu Muhua , Wang Xiao , Xu Jiang 
Published: October 2024

As a new quantitative analysis method for heavy-metal elements in soil, the main function of the polarization resolution model is to filter out the disturbance of other elements on the spectral signal of target plasma. In order to quantify the mechanism of improving detection performance, the spectral transmittance of plasma intensity in the polarization-resolved optical path has been derived, and the relationship between the intensity of polarization-resolved laser-induced breakdown spectroscopy (PRLIBS) and the characteristic peak wavelength has been defined. Using the spectral data in the wavelength range of 424.50–429.24 nm as the characteristic signal, a quantitative analysis method for detection of the Cr element in soil has been developed. The improvement of spectral intensity stability at the characteristic peak of Cr I 425.7 was analyzed, and the mechanism of enhancing the detection accuracy was elucidated. Research has shown that, based on the polarization characteristics of Cr element plasma, PRLIBS is not affected by the matrix effects of soil and characterizes the amplitude conversion from the reference concentration of Cr element to the plasma spectral intensity. The spectral transmittance of plasma spectra depends not only on the characteristic peak wavelength and complex refractive index of heavy-metal elements but also on the measurement conditions such as spatial geometric angles and reflectivity of the transmission medium.
Intraocular lens simulator using computational holographic display for cataract patients
Authors: Akyazi Deniz , Aygun Ugur , Sahin Afsun , Urey Hakan 
Published: October 2024

Purpose
To develop and validate a holography based vision simulator for the demonstration of expected postoperative vision corresponding to monofocal and multifocal intraocular lenses (IOL) to cataract patients before surgery.

Methods
An artificial eye model is used to measure the optical performance of different IOL types. The resultant aberrations and degradations are then modeled using phase holograms and shown to subjects on a holographic display. We measure the contrast and resolution loss, halos around the light sources, and point spread function (PSF) corresponding to three different IOLs. We tested the holography based vision simulator on 13 healthy subjects and 6 cataract patients.

Results
Monofocal, bifocal, and trifocal IOLs exhibited a contrast decrease of 5%, 42%, and 45% and a resolution limit of 4.49, 4.00, and 4.00 lp/mm (using 0.05 MTF criteria), respectively. Monofocal IOLs have the best resolution and contrast at the optimal focus distance, and multifocal lenses offer extended depth-of-field but exhibit prominent halos and reduced contrast/resolution.

Conclusion
We confirmed that the visual functions of IOLs could be successfully modeled using phase holograms and simulated using a holographic display without using a physical IOL. Patients can experience the effects of different IOL options prior to surgery, which helps with IOL selection, expectation management, and patient satisfaction.
The influence of spider news on online information-seeking
Authors: Drapeau Picard André-Philippe , Scott Catherine , Chuang Angela , Mammola Stefano 
Published: October 2024

Fear of spiders is a widespread condition often disproportionate to the actual danger spiders pose to humans. Likely rooted in evolutionary history, fear of spiders might also have a cultural component. Recent studies have shown that a significant fraction of spider-related media reports are misleading and sensationalistic. Information-seeking behaviours serve as common coping mechanisms for our fears and anxieties, yet the link between spider-related news stories and such behaviors remains unexplored.
We hypothesize that media reports foster concern about spiders, resulting in an increased awareness of spiders and health issues associated with them. We extracted 1486 reports in English from a public database providing a content-analysis of spider-related online traditional media reports published between 2010–2020. We examined whether the volume of spider-related queries in Google Trends, Wikipedia, and iNaturalist increased in the week following the publication of each news story.
Sensationalistic news stories were associated with a small, significant increase in search volumes, compared to non-sensationalistic ones. The search volume for “brown recluse” (Loxosceles reclusa), which are potentially dangerous spiders, was higher after the publication date of news related to human-spider encounters. There was a significant positive relationship between the number of spider-related news stories published in a given month and the traffic on target spider-related Wikipedia pages, especially so for the page on brown recluse spiders.
Our results suggest that traditional media have a detectable impact on the behaviour of the general public towards spiders, supporting the hypothesis that the fear of spiders is perpetuated by culture. Additionally, our findings indicate that information-seeking behaviour is a common response to learn about spiders and potentially fact-check spurious claims found in sensationalised news. By recognizing the role of media in shaping attitudes towards spiders and acknowledging the benefits of accurate representation, we can lay the foundation for a more informed and harmonious relationship between humans and spiders.
Resuming work roles after injury in a low-income context: Multiple factors influencing the return to work outcomes
Authors: Ahmed Ansha Nega , Finlayson Marcia , Addissie Adamu , Zewdie Ayalew , Lysaght Rosemary 
Published: October 2024

Background
Return to work (RTW) is an important outcome indicator for the effectiveness of rehabilitation services, and the functional status and overall recovery among individuals who have experienced injury. Despite the rising incidence of traumatic injury among economically productive citizens in Ethiopia, there is a paucity of evidence about the RTW status of injury survivors. This study examined factors associated with RTW success and determinants of time to RTW after injury in Ethiopia.

Methods
An institution-based cross-sectional study was conducted to collect data retrospectively one year after patients arrived at the study setting due to traumatic injuries. Medical records of all patients who visited the emergency room of a large public hospital in Addis Ababa were reviewed. Data were collected from survivors of traumatic injury, interviewed by telephone one year post-injury. Multivariable logistic regression and survival analysis were carried out to explore factors.

Results
Of the 251 participants, 75% were young adults (age </ = 39 years), 78% were male, 78% were urban residents, 41% were injured by road traffic collisions, and 59% returned to work within one year. The logistic regression model revealed short inpatient admission (AOR = 4.20; 95% CI: 2.10–8.50; p ≤ 0.001), no disability (AOR = 4.44; 95% CI: 2.10–9.60; p ≤ 0.001), motivation to RTW (AOR = 3.50; 95% CI: 1.61–7.50; p = 0.002), no chronic illness (AOR = 2.31; 95% CI: 1.14–4.70; p = 0.020), being in an administrative position (AOR = 5.32; 95% CI: 1.11–25.78; p = 0.038) and receiving injury compensation (AOR = 3.10; 95% CI: 1.22–7.73; p = 0.017) as factors for successful RTW within a year after injury. Further, the Cox regression analysis identified immediate access to healthcare after injury (AHR = 1.54; 95% CI: 1.05–2.25; p ≤ 0.026) and having injury of penetrative to internal organ, strain, sprain, dislocation or soft tissue (AHR = 1.81; 95% CI: 1.20–2.80; p = 0.007) as determinants of early RTW after traumatic injury.

Conclusion
The study uncovers factors crucial to RTW planning and interventions, and provides insights to minimize barriers, foster a smooth transition to employment, and optimize survivors’ lives after injury.