bluuebunny/crossref_metadata_2025_split huggingface dataset:
КЛІНІЧНА ЕФЕКТИВНІСТЬ ПРЕПАРАТУ, ЩО МІСТИТЬ ГЛЮКОЗАМІНУ ГІДРОХЛОРИД, У ЛІКУВАННІ СЕЧОКАМ’ЯНОЇ ХВОРОБИ ДОМАШНІХ КОТІВ
Authors: Morozenko D.V. , Glebova E.V. 
Published: October 2016

In the article the question of the effectiveness of treatment of domestic cats with urolithiasis which a preparation containing glucosamine hydrochloride was used in the scheme of therapeutic interventions (Uri–Easy). According to the research, it was found that the treatment regimen with the use of drug Uri–Easy containing glucosamine hydrochloride, promotes more rapid clinical recovery of the animals, as well as the dissolution of crystals of calcium tripelfosfat glycosaminoglycans and increasing concentration in urine. This is confirmed by the fact that the 14 day treatment the animals in the second group with glucosamine hydrochloride concentration glycosaminoglycan in urine was lower by 12.3% than that in healthy cats with only single crystals of calcium tripelfosfat encountered in urine sediment. In the first group of glycosaminoglycans content in urine on day 14 were 62.6% lower than the clinically healthy cats, the precipitate thus maintained a moderate amount of calcium tripelfosfat crystals. In this second group of glycosaminoglycan concentration on the 14th day it was closer to normal, and only a few crystals were observed in urine. Thus, we can say that the introduction to the treatment regimen of the drug containing glucosamine hydrochloride, to accelerate healing cats with urolithiasis, which is confirmed by laboratory tests. This allows us to recommend the drug Uri–Easy for the comprehensive treatment of domestic cats suffering from struvite urolithiasis.
НЕСПЕЦІФІЧНА РЕЗИСТЕНТНІСТЬ КОЗЕНЯТ ЗА ДІЇ ПРОБІОТИКА «ЕВІТАЛІЯ» В УМОВАХ НЕ РЕГУЛЬОВАНОГО МІКРОКЛІМАТУ
Authors: Petrenko A.N. , Kushch L.L. 
Published: October 2016

Probiotic «Evitaliya» is freeze–dried, specific strains of lactic acid microorganisms (Lactococcus lactis, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus helveticus, Propionibacterium fredenreichii ssp shernanii), they contain vitamins B1, B2, B6, B12, A, E, C iron minerals, calcium, magnesium.The purpose of the study was to clarify the effect of the probiotic ferment «Evitaliya» on nonspecific resistance of kids zaanovskoy breed microclimate conditions according VNTP (for sheep and goat breeding enterprises): the room temperature 12–14 °C, relative humidity of 55 – 70%, the carbon dioxide content – 1.5 – 1.8 l/m3 and ammonia – 10 – 15mg/m3 air bacterial contamination 15 – 20 tys. KOE/m3. Implementation of this goal was decided to use hygienic (temperature, relative humidity, air velocity); hematological (red blood cells, white blood cells, hemoglobin), biochemical (total protein, albumin, globulin); immune (humoral factors – lysozyme and bactericidal activity of blood serum, cell – the neutrophil phagocytic activity), statisticsGetting results and their novelty: for the first time tested the new probiotic yeast «Evitaliya», with its goats orally at a dose of – 200 ml/head in the morning and evening, 100 ml.It was found that the use of «Evitaliya» promotes activation of redox processes in the body kids, stimulation of erythropoiesis: increase in hemoglobin concentration of 0.56% (P ≤ 0.05), the number of red blood cells to – 10.2% (P ≤ 0.05).Use of the drug is moderately activates metabolic processes in the body of kids: increases total protein content by 7.14% (P ≤ 0.05), globulin – by 1.76% (P ≤ 0.05). Use of the drug «Evitaliya» at the indicated doses helps stimulate natural resistance olrganіzmu kids: humoral protection indicators (BASK) rose by 1.52% (LASK) by 1.81%, the cell indices (FA) compared to the control were higher – 4.97%.
Phase II Trial of Abiraterone Acetate Plus Prednisone in Black Men With Metastatic Prostate Cancer
Authors: Tsao Che-Kai , Sfakianos John , Liaw Bobby , Gimpel-Tetra Kiev , Kemeny Margaret , Bulone Linda , Shahin Mohammad , Oh William Kyu , Galsky Matthew David 
Published: October 2016

Abstract

Lessons Learned
The safety and activity findings of abiraterone acetate plus prednisone treatment in black men with mCRPC were similar to results from previously conducted studies with largely white populations. Poor trial accrual continues to be a challenge in black men with mCRPC and further efforts are needed to address such underrepresentation.

Background.
Self-identified black men have higher incidence and mortality from prostate cancer in the United States compared with white men but are dramatically underrepresented in clinical trials exploring novel therapies for metastatic castration-resistant prostate cancer (mCRPC).

Methods.
Black men with mCRPC were treated with abiraterone acetate (AA), 1,000 mg daily, and prednisone (P), 5 mg twice daily. The primary objective was to determine antitumor activity (defined by a ≥30% decline in prostate-specific antigen [PSA] level) and to correlate germline polymorphisms in androgen metabolism genes with antitumor activity. Secondary objectives included determining safety, post-treatment changes in measurable disease, and time to disease progression.

Results.
From April 2013 to March 2016, a total of 11 black men were enrolled and received AA plus P (AA+P); 7 of 10 evaluable patients were docetaxel naive. Post-treatment declines in PSA level of ≥30% were achieved in 90% of patients. The side effect profile was consistent with prior clinical trials exploring AA+P in mCRPC. Due to poor accrual, the study was closed prematurely with insufficient sample size for the planned pharmacogenetic analyses.

Conclusion.
In this small prospective study terminated for poor accrual, the safety and activity of AA+P in black men with mCRPC was similar to that reported in prior studies exploring AA in largely white populations. Further efforts are needed to address underrepresentation of black men in mCRPC trials.
Survival Outcomes in Asymptomatic Patients With Normal Conventional Imaging but Raised Carcinoembryonic Antigen Levels in Colorectal Cancer Following Positron Emission Tomography-Computed Tomography Imaging
Authors: Khan Khurum , Athauda Avani , Aitken Katharine , Cunningham David , Watkins David , Starling Naureen , Cook Gary J. , Kalaitzaki Eleftheria , Chau Ian , Rao Sheela 
Published: October 2016

Abstract

Background.
This study had two aims: (a) to evaluate the utility of fluorine 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) in detecting occult disease recurrence with raised carcinoembryonic antigen (CEA) and (b) to establish the prognostic effects of early detection of disease recurrence in patients with colorectal cancer (CRC).

Patients and Methods.
Clinico-pathological data were obtained from all consecutive patients undergoing CRC surveillance from 2004 to 2010 who had an elevated CEA level (&gt;3 ng/mL in nonsmokers, &gt;5 ng/mL in smokers) but normal or equivocal conventional investigations. Histopathological confirmation or a minimum of 12 months’ clinical and radiological follow-up were required to ascertain disease relapse.

Results.
A total of 1,200 patients were screened; of those, 88 (59% men; mean age, 66 years [SD, 9.6]) eligible patients (67 with normal and 21 with equivocal results on conventional investigations) were identified. Recurrent disease was detected in 56 of 88 patients (64%). The sensitivity of FDG PET-CT to detect recurrence was 49 of 56 (88%; 95% confidence interval [CI], 76%–95%) and specificity was 28 of 32 (88%; 95% CI, 71%–97%). Twenty-seven of 49 (55%) patients with PET-CT-detected relapsed disease were deemed eligible for further curative therapy; 19 (70%) went on to receive potentially curative therapy. The median time to progression (8.8 months [interquartile range (IQR), 4.5–19.1 months] vs. 2.2 months [IQR, 0.7–5.6]), median overall survival (39.9 months [IQR, 23.6–65.4 months] vs. 15.6 months [IQR, 7.3–25.7 months]), and 5-year survival (36.8% [95% CI, 16.5%–57.5%] vs. 6.1% [95% CI, 1.1%–17.6%]; p ≤ .001) were higher in patients who received potentially curative therapy than in those who received noncurative therapy.

Conclusion.
FDG PET-CT is a highly sensitive and specific tool for the detection of occult CRC recurrence. In &gt;50% of patients, recurrent disease may still be potentially amenable to curative therapy. Long-term survival can be achieved in such patients.
Two Applications of Particle Filter (PF) Method: Optimization and Fault Detection
Authors: Habibi Reza 
Published: October 2016

This paper considers two applications of PF method. The first part extends the work of Zhou et al. (2008) regarding the use of PF in optimization. Indeed, their simple state equation \(x(t)=x(t-1)\) is substituted first with Newton-Raphson (hereafter, NR) and then with Robbins-Monro (hereafter, RM) equations. The second part, the application of PF in Bayesian fault detection is seen. Conclusions are given.
Variability in Optimum Nitrogen Rates for Maize
Authors: Dhital Sulochana , Raun W. R. 
Published: October 2016

Maize (Zea maysL.) grain yield levels and the response to fertilizer nitrogen (N) are expected to change from year to year and from location to location. Because yield level and N response have been documented to be independent and are known to influence N demand, optimum N rates at the same location vary each year due to unpredictable changes in the environment. The objective of this study was to further analyze maize grain yield levels and optimum fertilizer N rates from published data in maize growing regions of the United States. Optimum N rates were determined by calculating the difference in N uptake between the highest‐yielding plot and the check plot (no N applied [0‐N]). The difference in grain N uptake between the fertilized plot and the 0‐N check plot was then divided by 0.33 (the assumed average N use efficiency) to estimate optimum N rate by site and year. For the 213 site‐years of data included in this study, grain yields in both the high N rate and check (0‐N) plots were highly variable. Optimum N rates fluctuated from year to year at all locations. Optimum N rates were not highly correlated with the high–N rate yield (R2= 0.20) or 0‐N check yield (R2= 0.16). The wide range in optimum N rates observed in all maize experiments suggests the need to adjust N rates by year and location. A potential solution is to use midseason sensor‐based technologies that can accurately predict yield potential and simultaneously encumber N responsiveness known to be independent of yield.Core IdeasOptimum fertilizer nitrogen rates for maize are highly variable.Demand for fertilizer nitrogen changes year to year.Yield level and nitrogen responsiveness are independent.Nitrogen use efficiency can improve by changing N rates every year.In‐season sensor based N management can optimize fertilizer nitrogen rates.
Effect of Sitagliptin on Kidney Function and Respective Cardiovascular Outcomes in Type 2 Diabetes: Outcomes From TECOS
Authors: Cornel Jan H. , Bakris George L. , Stevens Susanna R. , Alvarsson Michael , Bax Willem A. , Chuang Lee-Ming , Engel Samuel S. , Lopes Renato D. , McGuire Darren K. , Riefflin Axel , Rodbard Helena Wachslicht , Sinay Isaac , Tankova Tsvetalina , Wainstein Julio , Peterson Eric D. , Holman Rury R. 
Published: October 2016

OBJECTIVE
To evaluate chronic kidney disease (CKD) and cardiovascular outcomes in TECOS (Clinical trial reg. no. NCT00790205, clinicaltrials.gov) participants with type 2 diabetes and cardiovascular disease treated with sitagliptin, a dipeptidyl peptidase 4 inhibitor, according to baseline estimated glomerular filtration rate (eGFR).

RESEARCH DESIGN AND METHODS
We used data from 14,671 TECOS participants assigned in a double-blind design to receive sitagliptin or placebo added to existing therapy, while aiming for glycemic equipoise between groups. Cardiovascular and CKD outcomes were evaluated over a median period of 3 years, with participants categorized at baseline into eGFR stages 1, 2, 3a, and 3b (≥90, 60–89, 45–59, or 30–44 mL/min/1.73 m2, respectively).

RESULTS
Participants with eGFR stage 3b were older, were more often female, and had a longer duration of diabetes. Four-point major adverse cardiovascular event rates increased with lower baseline eGFR (3.52, 3.55, 5.74, and 7.34 events/100 patient-years for stages 1–3b, respectively). Corresponding adjusted hazard ratios for stages 2, 3a, and 3b versus stage 1 were 0.93 (95% CI 0.82–1.06), 1.28 (1.10–1.49), and 1.39 (1.13–1.72), respectively. Sitagliptin therapy was not associated with cardiovascular outcomes for any eGFR stage (interaction P values were all &gt;0.44). Kidney function declined at the same rate in both treatment groups, with a marginally lower but constant eGFR difference (−1.3 mL/min/1.73 m2) in those participants who were assigned to sitagliptin. Treatment differences in these eGFR values remained after adjustment for region, baseline eGFR, baseline HbA1c, time of assessment, and within-study HbA1c levels.

CONCLUSIONS
Impaired kidney function is associated with worse cardiovascular outcomes. Sitagliptin has no clinically significant impact on cardiovascular or CKD outcomes, irrespective of baseline eGFR.
State of the art atmospheric dispersion modelling: should the Gaussian plume model still be used?
Authors: Richter C. 
Published: October 2016

Abstract
For regulatory purposes with respect to licensing and supervision of airborne releases of nuclear installations, the Gaussian plume model is still in use in Germany. However, for complex situations the Gaussian plume model is to be replaced by a Lagrangian particle model. Now the new EU basic safety standards for protection against the dangers arising from exposure to ionising radiation (EU BSS) [1] asks for a realistic assessment of doses to the members of the public from authorised practices. This call for a realistic assessment raises the question whether dispersion modelling with the Gaussian plume model is an adequate approach anymore or whether the use of more complex models is mandatory.
Anti-Nuclear Mobilisation and Environmentalism in Europe: A View from Portugal (1976-1986)
Authors: Barca Stefania , Delicado Ana 
Published: October 2016

Abstract
The article addresses the rise of anti-nuclear mobilisation in Portugal in the 1970s against the backdrop of similar movements across Western Europe. After performing a brief review of the literature on social mobilisation against nuclear energy, an overview is provided of the available sociological literature on environmental mobilisation in Portugal, mostly developed in a comparative southern-European perspective. The second section adds new empirical evidence on Portuguese anti-nuclear mobilisation, and its connection with environmental mobilisation, based on in-depth research conducted through both archival scrutiny and oral history interviews. In the conclusion, a fresh perspective is offered on the contribution of the Portuguese case to the advancement of research on the relationship between anti-nuclear and environmental mobilisation in Western Europe.
Swedish Forestry, Forest Pasture Grazing by Livestock, and Game Browsing Pressure Since 1900
Authors: Kardell Örjan 
Published: October 2016

Abstract

Growing numbers of wild ungulates are increasingly seen by concerned authorities in Europe as posing serious management problems, which include increasing browsing pressure by moose (
Alces alces
) and roe deer (
Capreolus capreolus
) in Swedish forests. Recent investigations by the Swedish Forest Agency identify high browsing pressure as the main reason for a recent decline in regeneration of Scots pine (
Pinus sylvestris
), one of the two main commercial species in Swedish forestry. The high browsing pressure is also having a negative impact on biodiversity. Thus, voices within the forest community claim that browsing pressure has never been so high. This paper examines that claim from a historical perspective by comparing livestock grazing in forest pastures a century ago with contemporary game browsing, and identifying the main factors driving both the livestock exodus from Swedish forests during the first half of the twentieth century and the rapid increase in deer populations during the second half. Finally, testing the claim that browsing impact has never been so high, past grazing and present browsing are theoretically sized up and compared. Estimates of live weights and numbers of large herbivores in 1902 and 2012 are used. The result indicates that the claim might possibly be lacking in historical context.
'Dust Bowls', TVAs and Snowy River Waters: John Heyer,
The Valley is Ours
and an Early Post-War 'Image of Australia'
Authors: Bailey Janette-Susan 
Published: October 2016

Abstract

This paper introduces the story of the 1940s debate between the Australian state of Victoria and the north-bordering state of New South Wales, over Australia's Snowy Mountains Hydro Electric Scheme. It describes the campaign imagery generated by the state of Victoria and the Murray Valley Development League (MVDL) to promote their vision for a Murray Valley TVA. The focus is on Australian documentary film-maker John Heyer and
The Valley is Ours
(1948).
The Valley
was created to support the MVDL's claims that a scheme to benefit their valley would be the best post-war scheme for both New South Wales and Victoria, and for the nation. This paper takes a transnational and cultural approach to investigating this story. This is because Heyer used nationalist US concepts to strengthen Australian national myths - the film's transnational content was set to a nationalist purpose. This paper describes the environmental imagery - not just images, but sound and text, used by Heyer and the MVDL campaign, to convey a transnational set of ideas. It retrieves a material record from the archives, of what these transnational environmental ideas actually looked and sounded like. And it sheds light on the cultural influences and political forces behind the Murray TVA campaign and the film's creation.
Reverdy selon Du Bouchet
Authors: Collot Michel 
Published: October 2016

La relation privilégiée unissant Reverdy à Du Bouchet s’affirme à partir d’une reconnaissance mutuelle : le jeune poète prometteur échange, avec ce maître qui lui offre une alternative au surréalisme, des signes d’estime et d’intérêt. Du Bouchet consacre ainsi une étude approfondie à Reverdy en 1951, intitulée « Envergure de Reverdy », dont la réécriture radicale en 1992 dans Matière de l’interlocuteur permet de mesurer le chemin accompli par son auteur dans l’intervalle, d’un hommage initial à un dialogue post-mortem plus équilibré avec l’œuvre du maître ancien, et de l’idéal d’un rapport renoué avec le réel au constat aggravé d’un manque.
Quelques repères historiques pour une analyse de l’énonciation (d’Aristote à Benveniste)
Authors: Coquet Jean-Claude 
Published: October 2016

Le thème de l’énonciation est ancien. Il ne date pas du numéro de Langages de 1970 intitulé : « L’énonciation », mais ce numéro allait à contre-courant de l’analyse structurale qui l’avait exclu de son champ d’étude. Or les bases linguistiques de l’énonciation ont été posées très tôt dans notre univers occidental. Aristote est un témoin privilégié. Sa leçon a été suivie au cours des siècles. Port-Royal l’a énoncée dans sa Grammaire . Benveniste et un phénoménologue comme Merleau-Ponty en sont les continuateurs.
GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism
Authors: Na Yi Rang , Gu Gyo Jung , Jung Daun , Kim Young Won , Na Juri , Woo Jin Sun , Cho Joo Youn , Youn Hyewon , Seok Seung Hyeok 
Published: October 2016

Abstract
GM-CSF induces proinflammatory macrophages, but the underlying mechanisms have not been studied thus far. In this study, we investigated the mechanisms of how GM-CSF induces inflammatory macrophages. First, we observed that GM-CSF increased the extent of LPS-induced acute glycolysis in murine bone marrow–derived macrophages. This directly correlates with an inflammatory phenotype because glycolysis inhibition by 2-deoxyglucose abolished GM-CSF–mediated increase of TNF-α, IL-1β, IL-6, and IL-12p70 synthesis upon LPS stimulation. Increased glycolytic capacity is due to de novo synthesis of glucose transporter (GLUT)-1, -3, and -4, as well as c-myc. Meanwhile, GM-CSF increased 3-hydroxy-3-methyl-glutaryl-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway. Inhibition of acute glycolysis or 3-hydroxy-3-methyl-glutaryl-CoA reductase abrogated the inflammatory effects of GM-CSF priming in macrophages. Finally, mice with inflamed colons exposed to dextran sodium sulfate containing GLUT-1high macrophages led to massive uptake of [18F]-fluorodeoxyglucose, but GM-CSF neutralization reduced the positron-emission tomography signal in the intestine and also decreased GLUT-1 expression in colonic macrophages. Collectively, our results reveal glycolysis and lipid metabolism created by GM-CSF as the underlying metabolic constructs for the function of inflammatory macrophages.
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling
Authors: Pazdrak Konrad , Straub Christof , Maroto Rosario , Stafford Susan , White Wendy I. , Calhoun William J. , Kurosky Alexander 
Published: October 2016

Abstract
The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We examined the effect of cytokines typically overexpressed in the asthmatic airways on glucocorticoid signaling in in vitro activated eosinophils. An annexin V assay used to measure eosinophil apoptosis showed that cytokine combinations of IL-2 plus IL-4 as well as TNF-α plus IFN-γ, or IL-3, GM-CSF, and IL-5 alone significantly diminished the proapoptotic response to dexamethasone. We found that IL-2 plus IL-4 resulted in impaired phosphorylation and function of the nuclear glucocorticoid receptor (GCR). Proteomic analysis of steroid sensitive and resistant eosinophils identified several differentially expressed proteins, namely protein phosphatase 5 (PP5), formyl peptide receptor 2, and annexin 1. Furthermore, increased phosphatase activity of PP5 correlated with impaired phosphorylation of the GCR. Importantly, suppression of PP5 expression with small interfering RNA restored proper phosphorylation and the proapoptotic function of the GCR. We also examined the effect of lipoxin A4 on PP5 activation by IL-2 plus IL-4. Similar to PP5 small interfering RNA inhibition, pretreatment of eosinophils with lipoxin A4 restored GCR phosphorylation and the proaptoptotic function of GCs. Taken together, our results showed 1) a critical role for PP5 in cytokine-induced resistance to GC-mediated eosinophil death, 2) supported the dependence of GCR phosphorylation on PP5 activity, and 3) revealed that PP5 is a target of the lipoxin A4-induced pathway countering cytokine-induced resistance to GCs in eosinophils.