bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Postimplant Speech Perception and Language Skills Predict Long-Term Language and Neurocognitive Outcomes Following Pediatric Cochlear Implantation
Authors: Hunter Cynthia R. , Kronenberger William G. , Castellanos Irina , Pisoni David B. 
Published: July 2017

PurposeWe sought to determine whether speech perception and language skills measured early after cochlear implantation in children who are deaf, and early postimplant growth in speech perception and language skills, predict long-term speech perception, language, and neurocognitive outcomes.MethodThirty-six long-term users of cochlear implants, implanted at an average age of 3.4 years, completed measures of speech perception, language, and executive functioning an average of 14.4 years postimplantation. Speech perception and language skills measured in the 1st and 2nd years postimplantation and open-set word recognition measured in the 3rd and 4th years postimplantation were obtained from a research database in order to assess predictive relations with long-term outcomes.ResultsSpeech perception and language skills at 6 and 18 months postimplantation were correlated with long-term outcomes for language, verbal working memory, and parent-reported executive functioning. Open-set word recognition was correlated with early speech perception and language skills and long-term speech perception and language outcomes. Hierarchical regressions showed that early speech perception and language skills at 6 months postimplantation and growth in these skills from 6 to 18 months both accounted for substantial variance in long-term outcomes for language and verbal working memory that was not explained by conventional demographic and hearing factors.ConclusionSpeech perception and language skills measured very early postimplantation, and early postimplant growth in speech perception and language, may be clinically relevant markers of long-term language and neurocognitive outcomes in users of cochlear implants.Supplemental materialshttps://doi.org/10.23641/asha.5216200
Isotope exchange reactions involving HCO+ with CO: A theoretical approach
Authors: Mladenović M. , Roueff E. 
Published: July 2017

Aims. We aim to investigate fractionation reactions involved in the 12C/13C, 16O/18O, and 17O balance.
Methods. Full-dimensional rovibrational calculations were used to compute numerically exact rovibrational energies and thermal equilibrium conditions to derive the reaction rate coefficients. A nonlinear least-squares method was employed to represent the rate coefficients by analytic functions.
Results. New exothermicities are derived for 30 isotopic exchange reactions of HCO+ with CO. For each of the reactions, we provide the analytic three-parameter Arrhenius-Kooij formula for both the forward reaction and backward reaction rate coefficients, that can further be used in astrochemical kinetic models. Rotational constants derived here for the 17O containing forms of HCO+ may assist detection of these cations in outer space.
Base-Mediated Ring Opening of meso-Epoxides with 4-Aryl-NH-1,2,3-triazoles: Synthesis of trans-2-(Aryltriazolyl)cycloalkanols
Authors: Bhagat Ujjawal , Peddinti Rama ,   Kamaluddin
Published: July 2017

A novel method of nucleophilic ring-opening of meso-epoxides with 4-aryl-NH-1,2,3-triazoles has been developed under metal-free conditions. The epoxide-ring opening process were carried out in the presence of organic bases (DABCO/Et3N) in acetonitrile at 85 °C to afford a regioisomeric mixture of trans-2-(4-aryl-2H-1,2,3-triazol-2-yl)cycloalkanols (2,4-disubstituted triazoles) as major adducts and trans-2-(4-aryl-1H-1,2,3-triazol-1-yl)cycloalkanols (1,4-disubstituted triazoles) as minor adducts in excellent combined chemical yields (isolated yield up to 99%).
A Novel Mutation in the CLDN16 Gene in a Palestinian Family with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis
Authors: Abu-Libdeh Abdulsalam , Abu-Libdeh Bassam , Abdulhag Ulla 
Published: July 2017

AbstractFamilial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive renal disorder characterized by excessive renal magnesium and calcium loss, bilateral nephrocalcinosis, and progressive renal failure, due to impaired tubular reabsorption in the thick ascending loop of Henle. FHHNC is caused by loss of function mutations in the claudin-16 gene (CLDN16) and claudin-19 gene (CLDN19). A 2-month-old male infant presented with convulsions during hypomagnesemia, hypocalcemia, and hypophosphatemia, biochemical findings were consistent with FHHNC. There is a positive family history of the death of a 12 years old sibling due to renal failure. Gene sequencing of the CLDN16 revealed a novel missense mutation with the replacement of T by C in codon 120 located in exon 2, predicting cysteine to arginine substitution p.Cys120Arg. This is the first description of this missense mutation and the first confirmation of FHHNC by molecular testing in a Palestinian family which enables genetic counseling and future prenatal diagnosis.
The Natural History of Brain Arteriovenous Malformations
Authors: Peres Carlos , Yamaki Vitor , Figueiredo Eberval 
Published: July 2017

AbstractBrain arteriovenous malformations (AVMs) are relatively rare lesions with irreversible consequences in the context of hemorrhage. They are characterized by direct connections between arteries and veins without an intervening capillary network. The natural history of brain AVMs is controversial in the literature, with low evidence level gathered in the papers published, and with large divergence of results among them. A detailed understanding of the natural history is critical for treatment decision. The risk of development of deleterious outcomes such as hemorrhage or brain infarction should always be considered when submitting a patient to the risks of treatment. Several factors related to the patient and to the AVMs are determinants in the natural history of this disease. The topography, size, morphology and angioarchitecture of AVMs determine the risk of rupture. Large AVMs, those located in the posterior fossa and with deep venous drainage, have higher risk of rupture. Due to divergence in the literature regarding the natural history of AVMs, the choice of treatment should also consider experiences acquired over the years from reference centers with a high number of AVMs treated per year. We determined 7 variables that should be considered during the decision to treat an AVM: 1) previous hemorrhage; 2) aneurysm associated to the AVM; 3) direct arteriovenous fistula; 4) factors related to the nidus; 5) age and habits (smoking, sedentary lifestyle, diet quality); 6) the functional performance of the patient; 7) psychological factors.
Circulating Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 predict Three-months Outcome after Ischemic Stroke
Authors: Armbrust Moritz , Worthmann Hans , Dengler Reinhard , Schumacher Helmut , Lichtinghagen Ralf , Eschenfelder Christoph , Endres Matthias , Ebinger Martin 
Published: July 2017

Abstract
Reports on neuroprotective effects of Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) in ischemic brain tissue are inconsistent. The aim of this study was to determine if plasma levels of IGF-1 and IGFBP-3 in acute stroke patients are indicative of 3 months functional outcome.
Plasma levels were measured via chemiluminescence immunoassay in heparin blood samples of patients included in the EARLY trial (NCT00562588). Plasma samples were drawn on admission and 8 days post-stroke. Neurological deficits were assessed via modified Rankin Scale (mRS) 3 months post-stroke, resulting in favorable (mRS=0–2) or unfavorable (mRS=3–6) outcome. A multiple binary logistic regression including IGF-1 and IGFBP-3 levels and confounders was conducted.
Out of 404 included patients, 89 patients had an unfavorable outcome. Mean mRS on admission as well as 3 months post-stroke was 2 (±1). Low IGF-1 levels (day 8) were independently associated with a decreased risk of an unfavorable outcome (OR 0.61; 95%CI 0.37–0.99; p=0.044). Low IGFBP-3 levels (day 8) were independently associated with an unfavorable outcome (OR 2.75; 95%CI 1.56–4.84; p<0.001).
Low IGFBP-3 levels and high IGF-1 levels in the subacute phase are predictive of unfavorable outcome 3 months after stroke.
Wie aktiv ist die katholische Kirche bei der Prävention des sexuellen Missbrauchs? Erste Ergebnisse der MHG-Studie
Authors: Dreßing Harald , Dölling Dieter , Hermann Dieter , Horten Barbara , Collong Alexandra , Kruse Andreas , Schmitt Eric , Hinner Jörg , Bannenberg Britta , Hoell Andreas , Voss Elke , Salize Hans 
Published: July 2017

Zusammenfassung
Anliegen Ein Teilprojekt der von der Deutschen Bischofskonferenz ausgeschriebenen Studie „Sexueller Missbrauch an Minderjährigen durch katholische Priester, Diakone und männliche Ordensangehörige im Bereich der Deutschen Bischofskonferenz“ befasst sich mit Präventionsaspekten.
Methode Mit strukturierten Fragen wurden objektive Gegebenheiten zur Präventionsarbeit erfasst. Der Fragebogen wurde in allen 27 Diözesen Deutschlands bearbeitet.
Ergebnisse Das durchschnittlich für die Arbeit der Präventionsbeauftragten in allen Diözesen Deutschlands zur Verfügung stehende Stundenkontingent liegt bei einer 2/3-Stelle. Ende 2014 waren 59 % der Kleriker in Präventionsschulungen einbezogen. Der zeitliche Umfang der Präventionsschulungen variiert zwischen den einzelnen Diözesen stark.
Diskussion Die katholische Kirche Deutschlands hat umfangreiche Bestrebungen unternommen, eine flächendeckende Präventionsarbeit zur Vermeidung des sexuellen Missbrauchs an Minderjährigen in allen Bereichen zu implementieren. Der Stellenwert der Präventionsarbeit variiert zwischen den einzelnen Diözesen aber offensichtlich erheblich.
Zurück zum Pre Injury Level – der RTA Algorithmus für die
obere Extremität
Authors: Keller Matthias , Kurz Eduard 
Published: July 2017

ZusammenfassungNach Verletzungen oder Operationen der unteren Extremität haben sich
funktionsbasierte Rehabilitationskonzepte inzwischen etabliert. Aber auch
Patienten nach Schulter- oder Armverletzungen benötigen eine zielgerichtete und
objektive Steuerung der Nachbehandlung. Matthias Keller und Eduard Kurz stellen
ein funktionsbasiertes Konzept vor, um diese Patienten therapeutisch zu
begleiten. Level für Level finden sie so den Weg zurück zum Sport oder in die
Arbeitsbelastung – mithilfe des Return to Activity Algorithmus für die obere
Extremität.
Iron Pharmacokinetics in Women with Iron Deficiency Anaemia Following A Single Oral Dose of a Novel Formulation of Tardyferon (Prolonged Release Ferrous Sulphate)
Authors: Leary Andrew , Barthe Laurence , Clavel Thierry , Sanchez Claudie , Issiakhem Zahida , Paillard Bruno , Edmond Jean-Marc 
Published: July 2017

AbstractNumerous iron-containing preparations are available on the market; these vary in dosage, salt, chemical state of iron (ferric or ferrous) and in the iron delivery process (immediate or prolonged-release). Tardyferon® is a prolonged-release tablet containing 80 mg ferrous sulphate. The formulation has recently been modified; changes to the excipients which constitute the inert formulation matrix have allowed a decrease in tablet size for easier swallowing. The aim of this multicenter open-label study was to characterize the serum pharmacokinetics of iron in non-pregnant women aged 23–45 years with iron deficiency anaemia (IDA) following single oral administration of 160 mg Tardyferon® under fasting conditions. Blood samples were collected from the 29 participants before dosing and until 24 h post-dosing. Serum iron concentrations were determined using a routine colorimetric analytical method; pharmacokinetic parameters were derived using a non-compartmental approach. In these patients, median time to maximum serum concentrations (Tmax) was 4 h. Serum profiles were consistent with prolonged release; iron levels were elevated up to 12 h after dosing, with mean C12h still more than 7 times higher than baseline (CT0), and mean C2h and C8h representing 69.7% and 81.9% of the Cmax, respectively. In vitro dissolution testing performed on the clinical batch also demonstrated prolonged release of iron from this formulation. A single oral dose of 160 mg Tardyferon® administered under fasting conditions to this target population resulted in a long-lasting release of iron in the gastrointestinal tract, leading to optimal iron absorption. Moreover, Tardyferon® was well tolerated.
Psychotische Dekompensation, Substanzkonsum oder serotonerges Syndrom?
Authors: Speerforck Sven , Janowitz Deborah , Schomerus Georg , Grabe Hans 
Published: July 2017

ZusammenfassungEin junger Patient mit paranoider Schizophrenie, Abhängigkeitserkrankung und schwerer depressiver Episode entwickelt ein serotonerges Syndrom während einer Kombinationsbehandlung mit Sertralin und Ziprasidon. Die korrekte diagnostische Einordnung der klinischen Symptome ist, obwohl häufig schwierig, von größter Bedeutung.
Hitchhiking and epistasis give rise to cohort dynamics in adapting populations
Authors: Buskirk Sean W. , Peace Ryan Emily , Lang Gregory I. 
Published: July 2017

Significance
Mutations are the raw material for evolution. However, complex evolutionary dynamics make it challenging to identify which mutations drive adaptation. During adaptation in asexual populations, multiple mutations move synchronously through the population as mutational cohorts. Here we quantify the fitness effect of 116 mutations from 11 laboratory-evolved yeast populations. We show that only a fraction of genome evolution is strongly adaptive. We map driver and hitchhiker mutations to 31 mutational cohorts, and we identify 1 cohort in which mutations combine to provide a fitness benefit greater than the sum of their individual effects. Our analysis uncovers the roles of genetic hitchhiking and epistasis in determining which mutations ultimately succeed or fail in the context of a rapidly evolving microbial population.
Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels
Authors: Liu Jun , Zhao Yong Juan , Li Wan Hua , Hou Yun Nan , Li Ting , Zhao Zhi Ying , Fang Cheng , Li Song Lu , Lee Hon Cheung 
Published: July 2017

SignificanceThis study addresses a topological paradox in Ca2+signaling mediated by cyclic ADP-ribose (cADPR). The messenger is synthesized by CD38, thought to be a type ll ectoenzyme. Instead, we show that it exists naturally in two opposite membrane orientations and that the type III, with its catalytic domain facing the cytosol, is active in producing cellular cADPR. Its topology was resolved by a technique simultaneously targeting dual epitopes for protein identification, which identifies the intracellular type III CD38 unambiguously. It is also shown that its cADPR-synthesizing activity is regulated by cytosolic interactions with Ca2+and integrin-binding protein 1 (CIB1). The results indicate that membrane proteins are not necessarily expressed with only one unique membrane orientation set by sequence motifs as generally believed.
Microstructure and mechanical properties of Mg–Zn–Y alloy under a steady magnetic field
Authors: Zhang L. , Jin F. , Zhan W. , Hu P. H. , Zhou Q. 
Published: July 2017

This study examined the effect of steady magnetic field on the microstructure and mechanical properties of Mg–Zn–Y alloy reinforced by icosahedral quasicrystal phase. Results show that the microstructure of Mg–Zn–Y alloy was further refined as the magnetic field intensity increased. However, the primary α-Mg gradually became coarse over a certain value. No significant effect on the refinement of icosahedral quasicrystal phase was observed. The [Formula: see text] plane of the alloy treated by steady magnetic field was substituted by the (0002) plane as the primary plane. The [Formula: see text] plane was intensified gradually as the intensity of the magnetic field increased. The mechanical properties of Mg–Zn–Y alloy also improved with steady magnetic field treatment. This paper is part of a thematic issue on Light Alloys.
Evidence of Asian Carp Spawning Upstream of a Key Choke Point in the Mississippi River
Authors: Larson James H. , Knights Brent C. , McCalla S. Grace , Monroe Emy , Tuttle-Lau Maren , Chapman Duane C. , George Amy E. , Vallazza Jon M. , Amberg Jon 
Published: July 2017

Abstract
Bighead Carp Hypophthalmichthys nobilis, Silver Carp H. molitrix, and Grass Carp Ctenopharyngodon idella (collectively termed “Asian carp”) were introduced into North America during the 1960s and 1970s and have become established in the lower Mississippi River basin. Previously published evidence for spawning of these species in the upper Mississippi River has been limited to an area just downstream of Dam 22 (near Saverton, Missouri). In 2013 and 2014, we sampled ichthyoplankton at 18 locations in the upper Mississippi River main stem from Dam 9 through Dam 19 and in four tributaries of the Mississippi River (Des Moines, Skunk, Iowa, and Wisconsin rivers). We identified eggs and larvae by using morphological techniques and then used genetic tools to confirm species identity. The spawning events we observed often included more than one species of Asian carp and in a few cases included eggs that must have been derived from more than one upstream spawning event. The upstream extent of genetically confirmed Grass Carp ichthyoplankton was the Wisconsin River, while Bighead Carp and Silver Carp ichthyoplankton were observed in Pool 16. In all these cases, ichthyoplankton likely drifted downstream for several hours prior to collection. Higher water velocities (and, to a lesser extent, higher temperatures) were associated with an increased likelihood of observing eggs or larvae, although the temperature range we encountered was mostly above 17°C. Several major spawning events were detected in 2013, but no major spawning events were observed in 2014. The area between Dam 15 and Dam 19 appears to be the upstream edge of spawning activity for both Silver Carp and Bighead Carp, suggesting that this area could be a focal point for management efforts designed to limit further upstream movement of these species.
Received July 18, 2016; accepted May 4, 2017Published online July 19, 2017
Addiction Severity Index Profile of Persons who Reenter Treatment for Substance use Disorders
Authors: Simoneau Hélène , Brochu Serge 
Published: July 2017

Background Despite a growing interest in persons with multiple treatment reentries, few studies have defined their clinical profile. The aim of this study was to compare the severity profile of substance use disorder and related problems of persons who reenter treatment with the profile of those who come in for treatment for the first time. Methods A data bank containing 6651 Addiction Severity Index (ASI) interviews from 3 rehabilitation centers was used for the analyses. Results All the ASI composite scores were significantly higher among persons who reentered treatment than among those who came for the first time. Conclusion The results support the hypothesis of a more severe ASI profile and substance use–related problems among persons who reenter treatment compared with those who come for the first time. Consequently, they have greater needs, and the treatment offered should be adjusted accordingly.
CCQM-K108.2014: determination of arsenic species and total arsenic in brown rice flour
Authors: Inagaki K , Narukawa T , Hioki A , Miyashita S , Long S E , Ellisor M B , Peng S L , Dewi F , Shin R , Kapp T , Wai-hong F , Hei-shing C , Chao W , Kaewkhomdee N , Taebunpakul S , Thiengmanee U , Yafa C 
Published: July 2017

The key comparison CCQM-K108.2014 was organised by the Inorganic Analysis Working Group (IAWG) of CCQM to test the abilities of the national metrology institutes (NMIs) or the designated institutes (DIs) to measure the mass fractions of inorganic arsenic (i-As, sum of the amount of arsenite [As(III)] and arsenate [As(V)]), dimethylarsinic acid (DMAA), and total arsenic (total As) in brown rice flour. This was the follow-up comparison for the CCQM-K108 & CCQM-P147 (Cd, As, inorganic arsenic, and DMAA in brown rice flour).
For total As, no strong outliers among the reported values were observed, and the distribution of the results was narrow, within 3% around the median. For i-As and DMAA, the distributions of the results were slightly wider than that for total arsenic, but no strong outliers among the reported values of i-As and DMAA were observed. Two potentially bias sources, an extraction efficiency of As species (the ratio of the sum of i-As and DMAA to total As) and the quality of primary standard of DMAA, were discussed. The extraction efficiency was estimated as the ratio of the sum of i-As and DMAA to total As. In the previous comparison (CCQM-K108 & CCQM-P147), the extraction efficiency was one of the largest bias sources for i-As and DMAA. However, in this study, all the extraction efficiencies estimated from the reported values were close to 100 %. Regarding the quality of the primary standard solutions, no significant difference was observed among the primary standard solution used by the participants. These results suggest the two potential bias sources mentioned above would not have been majors in this study, and then the technical issues in the previous comparison had been overcome.
Accounting for relative expanded uncertainty, a comparability of measurement was successfully demonstrated by the participating NMIs and DIs for the measurement of total As at the level of less than 0.7 mg/kg, i-As at the level of less than 0.6 mg/kg, and DMAA at the level of less than 0.1 mg/kg. These are expected that total arsenic and i-As at mass fractions greater than 0.1 mg/kg and DMAA at mass fractions greater than 0.005 mg/kg in rice flour can be determined by each participant using the same technique(s) employed for this key comparison to achieve similar uncertainties mentioned in the present report. Furthermore, the results of this key comparison can be utilised along with the IAWG core capability approach.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).