bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Autonomy on Health-seeking Behaviour
Authors: S. Nayak , Varambally K.V.M. 
Published: February 2017

Background: A strong body of evidence suggests the presence of positive association between autonomy and health-seeking behaviour among women. It has been examined that women’s autonomy is a significant influencer refining the dismal state of maternal health. The paper also tries to probe the influence of dimensions of women’s autonomy and the other associated factors on health-seeking behaviour among women, in the rural contour of India. Method: A multistage sampling technique is employed to select 600 women from the rural households in Karnataka state of India. A structured questionnaire was employed to collect the data and SPSS 16 version employed to analyze the data collected. Descriptive statistics, bivariate analysis and logistics regression were carried out to identify the influence of dimensions of women’s autonomy on healthcare service utilization. Results: Women’s autonomy significantly influences health-seeking behaviour. Woman’s control over economic resources at the household level did not influence woman’s decision to seek healthcare, whereas woman’s freedom of movement had a significant influence on their health-seeking behaviour.
Trait neuroticism, extraversion, and conscientiousness in multiple sclerosis: Link to cognitive impairment?
Authors: Roy Shumita , Drake Allison S , Eizaguirre María Bárbara , Zivadinov Robert , Weinstock-Guttman Bianca , Chapman Benjamin P , Benedict Ralph HB 
Published: February 2017

Background: Previous research suggests that patients with multiple sclerosis (MS) have higher neuroticism, lower extraversion, and lower conscientiousness relative to healthy controls (HCs). However, the prevalence of this maladaptive profile in MS and its relation to cognition is unknown. Objective: Determine prevalence of maladaptive personality among MS patients, compared to HCs, and examine how it relates to cognitive dysfunction. Methods: A sample of 275 MS patients and 55 HCs completed neuroperformance measures of information processing speed and memory. Self and informant ratings were obtained on the NEO Five-Factor Inventory. Results: MS patients had higher neuroticism and lower extraversion than HCs. Cognitively impaired patients were also lower in conscientiousness. Cluster analysis revealed a configuration of these same three traits, representing a maladaptive profile. This profile was found in 50% of the overall MS sample, compared to 24% of HCs. However, only cognitively impaired MS patients had a higher prevalence of maladaptive personality compared to HCs. Among cognitively impaired patients, those with maladaptive traits were impaired in more cognitive domains than those with more adaptive traits. Conclusion: Cognitively impaired MS patients have a higher prevalence of seemingly maladaptive traits compared to HCs, demonstrating an association between cognition and personality in MS.
Multiple sclerosis: Serum-derived exosomes express myelin proteins
Authors: Galazka Grazyna , Mycko Marcin P , Selmaj Igor , Raine Cedric S , Selmaj Krzysztof W 
Published: February 2017

Background: Exosomes are small extracellular vesicles that provide cell-to-cell communication and are involved in immunoregulation. Objective: To investigate serum exosomes for the presence of myelin proteins outside the central nervous system (CNS) and their role in multiple sclerosis (MS). Methods: Serum, cerebrospinal fluid (CSF), and peripheral blood mononuclear cell (PBMC) samples were collected from 45 patients with relapsing–remitting MS (RRMS), 30 patients with secondary progressive MS (SPMS), and 45 healthy controls. Exosomes were isolated using a polymer formulation method, and their size, concentration, and CNS myelin protein contents were measured by a nanoparticle tracking analysis, enzyme-linked immunosorbent assays, and Western blot. Results: We found that exosomes expressed three major myelin proteins, myelin basic protein, proteolipid protein, and myelin oligodendrocyte glycoprotein (MOG). Exosomal content of MOG strongly correlated with disease activity and was highest in RRMS patients in relapse and in SPMS patients. Serum-derived exosomes induced proliferation of MOG-T cell receptor transgenic T cells confirming that serum exosomes maintained MOG immunogenicity. Conclusion: Exosomes isolated outside CNS tissue expressed myelin proteins, and the presence of MOG correlated strongly with disease activity. We conclude that exosomes might enhance and/or perpetuate anti-myelin immune reactions in MS and may provide novel markers of disease activity.
Tranexamic acid for acute intracerebral hemorrhage growth predicted by spot sign trial: Rationale and design
Authors: Liu Liping , Wang Yilong , Meng Xia , Li Na , Tan Ying , Nie Ximing , Liu Dacheng , Zhao Xingquan 
Published: February 2017

Rationale Acute intracerebral hemorrhage inflicts a high-economic and -health burden. Computed tomography angiography spot sign is a predictor of hematoma expansion, is associated with poor clinical outcome and is an important stratifying variable for patients treated with haemostatic therapy. Aims We aim to compare the effect of treatment with tranexamic acid to placebo for the prevention of hemorrhage growth in patients with high-risk acute intracerebral hemorrhage with a positive spot sign. Design The tranexamic acid for acute intracerebral hemorrhage growth predicted by spot sign (TRAIGE) is a prospective, multicenter, placebo-controlled, double-blind, investigator-led, randomized clinical trial that will include an estimated 240 participants. Patients with intracerebral hemorrhage demonstrating symptom onset within 8 h and with the spot sign as a biomarker for ongoing hemorrhage, and no contraindications for antifibrinolytic therapy, will be enrolled to receive either tranexamic acid or placebo. The primary outcome measure is the presence of hemorrhage growth defined as an increase in intracerebral hemorrhage volume >33% or >6 ml from baseline to 24 ± 2 h. The secondary outcomes include safety and clinical outcomes. Conclusion The TRAIGE trial evaluates the efficacy of haemostatic therapy with tranexamic acid in the prevention of hemorrhage growth among high-risk patients with acute intracerebral hemorrhage.
Bovine serum albumin–glutaraldehyde (BioGlue®) tissue adhesive versus standard renorrhaphy following renal mass enucleation: a retrospective comparison
Authors: Bahouth Zaher , Moskovitz Boaz , Halachmi Sarel , Nativ Ofer 
Published: February 2017

Background: To present the operative and post-operative comparison between patients who underwent tumor-bed closure with sutures compared with bovine serum albumin–glutaraldehyde (BioGlue®) tissue sealant only. Methods: We retrospectively analyzed data from our ongoing database of 507 eligible patients who underwent open NSS nephron-sparing surgery in our department between January 1995 and May 2014. Patients had tumor-bed closure with sealant adhesive (255 patients) or standard suture technique (252 patients). Demographic, clinical and perioperative data were compared between the two groups, by Chi-square test or by Fisher–Irwin exact test for categorical variables, and by t test for differences in means or by Wilcoxon rank sum test for continuous variables. A multivariate analysis was also done. Results: Patients’ baseline characteristics showed similar distribution of the analyzed parameters among both groups, with few differences: younger age in the sealant group (65.4 versus 68.4 years, p = 0.01) and slightly larger mass size in the suture group (4.0 versus 3.9 cm, p = 0.03). Ischemia time was significantly shorter in the sealant group (21.8 versus 27.0 minutes, p = 0001). Blood loss and transfusion rate (0.8% versus 11.9%, p = 0.0001) were significantly less in the sealant group. A multivariate analysis showed date of surgery and blood loss as the major parameters affecting transfusion rate. Conclusions: Closing the tumor bed with BioGlue® tissue adhesive is feasible, safe, can shorten ischemia time and potentially reduce transfusion rate.
Computed tomography perfusion-based selection of endovascularly treated acute ischaemic stroke patients – Are there lessons to be learned from the pre-evidence era?
Authors: Psychogios Marios-Nikos , Knauth Michael , Bshara Raya , Schregel Katharina , Tsogkas Ioannis , Papageorgiou Ismini , Maier Ilko , Liman Jan , Behme Daniel 
Published: February 2017

Introduction Some of the latest groundbreaking trials suggest that noncontrast cranial computed tomography and computed tomography-angiography are sufficient tools for patient selection within six hours of symptom onset. Before endovascular stroke therapy became the standard of care, patient selection was one of the most useful tools to avoid futile reperfusions. We report the outcomes of endovascularly treated stroke patients selected with a perfusion-based paradigm and discuss the implications in the current era of endovascular treatment. Material and methods After an interdisciplinary meeting in September 2012 we agreed to select thrombectomy candidates primarily based on computed tomography perfusion with a cerebral blood volume Alberta Stroke Program Early Computed Tomography Scale (CBV-ASPECTS) of <7 being a strong indicator of futile reperfusion. In this study, we retrospectively screened all patients with an M1 thrombosis in our neurointerventional database between September 2012 and December 2014. Results In 39 patients with a mean age of 69 years and a median admission National Institute of Health Stroke Scale of 17 the successful reperfusion rate was 74% and the favourable outcome rate at 90 days was 56%. Compared to previously published data from our database 2007–2011, we found that a two-point increase in median CBV-ASPECTS was associated with a significant increase in favourable outcomes. Conclusion Computed tomography perfusion imaging as an additional selection criterion significantly increased the rate of favourable clinical outcome in patients treated with mechanical thrombectomy. Although computed tomography perfusion has lost impact within the six-hour period, we still use it in cases beyond six hours as a means to broaden the therapeutic window.
The impact of database restriction on pharmacovigilance signal detection of selected cancer therapies
Authors: Hauben Manfred , Hung Eric , Wood Jennifer , Soitkar Amit , Reshef Daniel 
Published: February 2017

Background: The aim of this study was to investigate whether database restriction can improve oncology drug pharmacovigilance signal detection performance. Methods: We used spontaneous adverse event (AE) reports in the United States (US) Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. Positive control (PC) drug medical concept (DMC) pairs were selected from safety information not included in the product’s first label but subsequently added as label changes. These medical concepts (MCs) were mapped to the Medical Dictionary for Regulatory Activities (MedDRA) preferred terms (PTs) used in FAERS to code AEs. Negative controls (NC) were MCs with circumscribed PTs not included in the corresponding US package insert (USPI). We calculated shrinkage-adjusted observed-to-expected (O/E) reporting frequencies for the aforementioned drug–PT pairs. We also formulated an adjudication framework to calculate performance at the MC level. Performance metrics [sensitivity, specificity, positive and negative predictive value (PPV, NPV), signal/noise (S/N), F and Matthews correlation coefficient (MCC)] were calculated for each analysis and compared. Results: The PC reference set consisted of 11 drugs, 487 PTs, 27 MCs, 37 drug–MC combinations and 638 drug–event combinations (DECs). The NC reference set consisted of 11 drugs, 9 PTs, 5 MCs, 40 drug–MC combinations and 67 DECs. Most drug–event pairs were not highlighted by either analysis. A small percentage of signals of disproportionate reporting were lost, more noise than signal, with no gains. Specificity and PPV improved whereas sensitivity, NPV, F and MCC decreased, but all changes were small relative to the decrease in sensitivity. The overall S/N improved. Conclusion: This oncology drug restricted analysis improved the S/N ratio, removing proportionately more noise than signal, but with significant credible signal loss. Without broader experience and a calculus of costs and utilities of correct versus incorrect classifications in oncology pharmacovigilance such restricted analyses should be optional rather than a default analysis.
Somatic mutations in children with GATA2-associated myelodysplastic syndrome who lack other features of GATA2 deficiency
Authors: Fisher Kevin E. , Hsu Amy P. , Williams Christopher L. , Sayeed Hadi , Merritt Brian Y. , Elghetany M. Tarek , Holland Steven M. , Bertuch Alison A. , Gramatges Maria Monica 
Published: February 2017

Key Points
Children with primary MDS should be tested for GATA2 mutations, regardless of karyotype, family history, or features of GATA2 deficiency. Screening children with GATA2-MDS for somatic mutations may reveal mutations predictive of clinical outcomes.
Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients
Authors: Botta Cirino , Ciliberto Domenico , Rossi Marco , Staropoli Nicoletta , Cucè Maria , Galeano Teresa , Tagliaferri Pierosandro , Tassone Pierfrancesco 
Published: February 2017

Key Points
Different therapeutic agents are currently available for the treatment of RRMM. By performing an NMA, we identified a lenalidomide-dexamethasone + mAb regimen as the most active therapeutic option in this setting.
Effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure and markers of arterial stiffness in patients with type 2 diabetes mellitus: a post hoc analysis
Authors: Pfeifer Michael , Townsend Raymond R. , Davies Michael J. , Vijapurkar Ujjwala , Ren Jimmy 
Published: February 2017

Abstract
Background
Physiologic determinants, such as pulse pressure [difference between systolic blood pressure (SBP) and diastolic BP (DBP)], mean arterial pressure (2/3 DBP + 1/3 SBP), and double product [beats per minute (bpm) × SBP], are linked to cardiovascular outcomes. The effects of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on pulse pressure, mean arterial pressure, and double product were assessed in patients with type 2 diabetes mellitus (T2DM).

Methods
This post hoc analysis was based on pooled data from four 26-week, randomized, double-blind, placebo-controlled studies evaluating canagliflozin in patients with T2DM (N = 2313) and a 6-week, randomized, double-blind, placebo-controlled, ambulatory BP monitoring (ABPM) study evaluating canagliflozin in patients with T2DM and hypertension (N = 169). Changes from baseline in SBP, DBP, pulse pressure, mean arterial pressure, and double product were assessed using seated BP measurements (pooled studies) or averaged 24-h BP assessments (ABPM study). Safety was assessed based on adverse event reports.

Results
In the pooled studies, canagliflozin 100 and 300 mg reduced SBP (−4.3 and −5.0 vs −0.3 mmHg) and DBP (−2.5 and −2.4 vs −0.6 mmHg) versus placebo at week 26. Reductions in pulse pressure (−1.8 and −2.6 vs 0.2 mmHg), mean arterial pressure (−3.1 and −3.3 vs −0.5 mmHg), and double product (−381 and −416 vs −30 bpm × mmHg) were also seen with canagliflozin 100 and 300 mg versus placebo. In the ABPM study, canagliflozin 100 and 300 mg reduced mean 24-h SBP (−4.5 and −6.2 vs −1.2 mmHg) and DBP (−2.2 and −3.2 vs −0.3 mmHg) versus placebo at week 6. Canagliflozin 300 mg provided reductions in pulse pressure (−3.3 vs −0.8 mmHg) and mean arterial pressure (−4.2 vs −0.6 mmHg) compared with placebo, while canagliflozin 100 mg had more modest effects on these parameters. Canagliflozin was generally well tolerated in both study populations.

Conclusions
Canagliflozin improved all three cardiovascular physiologic markers, consistent with the hypothesis that canagliflozin may have beneficial effects on some cardiovascular outcomes in patients with T2DM.
Trial registration ClinicalTrials.gov Identifier: NCT01081834 (registered March 2010); NCT01106677 (registered April 2010); NCT01106625 (registered April 2010); NCT01106690 (registered April 2010); NCT01939496 (registered September 2013)
Understanding and evaluating the behavior of technical users. A study of developer interaction at StackOverflow
Authors: Ahmed Tanveer , Srivastava Abhishek 
Published: February 2017

AbstractThis paper is focused on analyzing the details of one of the most widely used Q&A technical discussion forums on the Internet: StackOverflow. StackOverflow is a huge source of information for both academics and industry practitioners and its analysis can provide useful insights. This is evident by a growing body of work dedicated to the study of this platform. There are several papers that have taken the ‘platform’ as an analyzing point to gain a few useful insights into the practices adopted by software developers. However, different from current literature, the objective of this paper is to explore the habit of users, more specifically, we want to find out how do technical users behave online? In doing so, we attempt to present a new picture that focuses more on the human aspect of this online community. We neither focus on the technical aspects of the platform nor do we focus on the technical capabilities of developers, rather, the focus of this paper is to explore the humanistic point of view of technical users. To do that, we mine StackOverflow’s repositories to find a few patterns that raise several questions. The observations presented in this paper highlight real world implications of having open call based software engineering platforms. Further, we conduct a survey of StackOverflow users to find an answer to one of the highly talked about topics on Meta (a discussion forum for StackOverflow). The subject of the survey concerns changing participation habit of users. As the paper progresses forward, we discuss factors that raise the issue of professionalism and ethics at this online venue. The findings show several malpractices happening at StackOverflow. We present a detailed analysis and discuss these issues in this paper.
Passive seismic reflection interferometry: A case study from the Aquistore CO2storage site, Saskatchewan, Canada
Authors: Cheraghi Saeid , White Donald J. , Draganov Deyan , Bellefleur Gilles , Craven James A. , Roberts Brian 
Published: February 2017

Seismic reflection interferometry has recently been tested in a few resource-exploration applications. We have evaluated passive seismic interferometry results for data from the Aquistore [Formula: see text] storage site, Saskatchewan, Canada, with the objective of testing the method’s ability to image the subsurface geology and its potential for time-lapse imaging. We analyzed passive seismic data recorded along two perpendicular geophone lines for two time periods that include 23 days in June 2014 and 13 days in February 2015. Beam-forming analysis showed that a nearby power plant is the dominant source of ambient noise. We retrieved virtual shot gathers not only by correlating long noise panels (1 h) for both recording periods, but also by correlating shorter noise panels (10 s) from two days of each recording period. We applied illumination diagnosis to the noise panels from the two chosen days for each period to help suppress the surface waves. Comparisons of the common-midpoints stacked sections, resulting from the virtual shot gathers, with colocated active-source images and log-based synthetic seismograms showed that the best ambient-noise images were obtained for the longest recording periods. The application of illumination diagnosis revealed that only a small percentage of the noise panels are dominated by body waves. Thus, images formed using only this subset of noise panels failed to improve the images obtained from the 23 and 13 days of noise recording. To evaluate the passive images, we performed log-based correlations that showed moderate correlation ranging from approximately 0.5–0.65 in the two-way time range of 0.8–1.5 s. For the 13 to 23 days of noise used in our analysis, the resulting images at the reservoir depth of 3200 m or [Formula: see text] are unlikely to be suitable for time-lapse imaging at this site. This is most likely due to the limited directional illumination and dominance of surface-wave noise.
Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group
Authors: Shaikh Furqan , Cullen John W. , Olson Thomas A. , Pashankar Farzana , Malogolowkin Marcio H. , Amatruda James F. , Villaluna Doojduen , Krailo Mark , Billmire Deborah F. , Rescorla Frederick J. , Egler Rachel A. , Dicken Bryan J. , Ross Jonathan H. , Schlatter Marc , Rodriguez-Galindo Carlos , Frazier A. Lindsay 
Published: February 2017

Purpose To investigate whether event-free survival (EFS) can be maintained among children and adolescents with intermediate-risk (IR) malignant germ cell tumors (MGCT) if the administration of cisplatin, etoposide, and bleomycin (PEb) is reduced from four to three cycles and compressed from 5 to 3 days per cycle. Patients and Methods In a phase 3, single-arm trial, patients with IR MGCT (stage II-IV testicular, II-III ovarian, I-II extragonadal, or stage I gonadal tumors with subsequent recurrence) received three cycles of PEb. A parametric comparator model specified that the observed EFS rate should not be significantly < 92%. As recommended for trials that test a reduction of therapy, a one-sided P value ≤ .10 was used to indicate statistical significance. In a post hoc analysis, we also compared results to the EFS rate of comparable patients treated with four cycles of PEb in two prior studies. Results Among 210 eligible patients enrolled from 2003 to 2011, 4-year EFS (EFS4) rate was 89% (95% confidence interval, 83% to 92%), which was significantly lower than the 92% threshold of the comparison model ( P = .08). Among 181 newly diagnosed patients, the EFS4 rate was 87%, compared with 92% for 92 comparable children in the historical cohort ( P = .15). The EFS4 rate was significantly associated with stage (stage I, 100%; stage II, 92%; stage III, 85%; and stage IV, 54%; P < .001). Conclusion The EFS rate for children with IR MGCT observed after three cycles of PEb was less than that of a prespecified parametric model, particularly for patients with higher-stage tumors. These data do not support a reduction in the number of cycles of PEb from four to three. However, further investigation of a reduction in the number of cycles for patients with lower-stage tumors is warranted.