bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of severity of retinal vascular changes and cardiac remodelling in systemic hypertension
Authors: Varghese Mary , Adhyapak Srilakshmi M. , Thomas Tinku , Sunder Meera , Varghese Kiron 
Published: February 2016

Objectives: The aim of the study was to explore the association between hypertensive retinopathy, grades of retinopathy and cardiac remodelling. Methods: This was a cross-sectional observational study. A total of 500 consecutive hypertensive adults from the in-patient population were studied for the presence of hypertensive retinopathy by dilated fundoscopy. The presence of cardiac remodelling due to hypertension was studied both by electrocardiography (ECG) and echocardiography. Hypertensive target organ damage in other organs was also screened. In addition, the association of grades of hypertensive retinopathy with target organ damage was also analyzed. Results: Systolic blood pressure (BP) at presentation and duration of hypertension showed no relationship with markers of hypertensive heart disease. However, diastolic BP was significantly higher in patients with retinopathy. Hypertensive retinopathy was diagnosed in 324 subjects of whom 90 had grades 3 and 4 retinopathy. Patients with grades 3 and 4 retinopathy had significant associations with ECG evidence of left ventricular (LV) strain pattern and left atrial enlargement, and a weaker association with left ventricular hypertrophy (LVH) using QRS voltage criteria (Sokolov–Lyon). On echocardiography, grades 3 and 4 retinopathy were significantly associated with LVH, left atrial enlargement and reduced left ventricular ejection fraction (LVEF), as well as with higher creatinine values. A large number of these patients presented with heart failure. Cardiac remodelling was not seen in patients without retinopathy and was uncommon in patients with grades 1 and 2 retinopathy. Conclusion: Grades 3 and 4 retinopathy demonstrated a significant association with LV strain pattern and left atrial enlargement on ECG, LVH and reduced LVEF on echocardiography as well as with heart failure. There was no relationship with systolic BP and duration of hypertension, while diastolic BP showed a significant positive correlation. Signs of hypertensive heart disease were practically absent in patients without hypertensive retinopathy and uncommon in those with grade 1–2 alterations.
Hybrid Closed-Loop Insulin Delivery in Type 1 Diabetes During Supervised Outpatient Conditions
Authors: Grosman Benyamin , Ilany Jacob , Roy Anirban , Kurtz Natalie , Wu Di , Parikh Neha , Voskanyan Gayane , Konvalina Noa , Mylonas Chrystaleni , Gottlieb Rebecca , Kaufman Francine , Cohen Ohad 
Published: February 2016

Background: Efficacy and safety of the Medtronic Hybrid Closed-Loop (HCL) system were tested in subjects with type 1 diabetes in a supervised outpatient setting. Methods: The HCL system is a prototype research platform that includes a sensor-augmented insulin pump in communication with a control algorithm housed on an Android-based cellular device. Nine subjects with type 1 diabetes (5 female, mean age 53.3 years, mean A1C 7.2%) underwent 9 studies totaling 571 hours of closed-loop control using either default or personalized parameters. The system required meal announcements with estimates of carbohydrate (CHO) intake that were based on metabolic kitchen quantification (MK), dietician estimates (D), or subject estimates (Control). Postprandial glycemia was compared for MK, D, and Control meals. Results: The overall sensor glucose mean was 145 ± 43, the overall percentage time in the range 70-180 mg/dL was 80%, the overall percentage time <70 mg/dL was 0.79%. Compared to intervals of default parameter use (225 hours), intervals of personalized parameter use (346 hours), sensor glucose mean was 158 ± 49 and 137 ± 37 mg/dL ( P < .001), respectively, and included more time in range (87% vs 68%) and less time below range (0.54% vs 1.18%). Most subjects underestimated the CHO content of meals, but postprandial glycemia was not significantly different between MK and matched Control meals ( P = .16) or between D and matched Control meals ( P = .76). There were no episodes of severe hypoglycemia. Conclusions: The HCL system was efficacious and safe during this study. Personally adapted HCL parameters were associated with more time in range and less time below range than default parameters. Accurate estimates of meal CHO did not contribute to improved postprandial glycemia.
The Potential Cost Implications of Averting Severe Hypoglycemic Events Requiring Hospitalization in High-Risk Adults With Type 1 Diabetes Using Real-Time Continuous Glucose Monitoring
Authors: Bronstone Amy , Graham Claudia 
Published: February 2016

Background: Severe hypoglycemia remains a major barrier to optimal diabetes management and places a high burden on the US health care system due to the high costs of hypoglycemia-related emergency visits and hospitalizations. Patients with type 1 diabetes (T1DM) who have hypoglycemia unawareness are at a particularly high risk for severe hypoglycemia, the incidence of which may be reduced by the use of real-time continuous glucose monitoring (RT-CGM). Methods: We performed a cost calculation using values of key parameters derived from various published sources to examine the potential cost implications of standalone RT-CGM as a tool for reducing rates of severe hypoglycemia requiring hospitalization in adult patients with T1DM who have hypoglycemia unawareness. Results: In a hypothetical commercial health plan with 10 million members aged 18-64 years, 9.3% (930 000) are expected to have diagnosed diabetes, with approximately 5% (46 500) having T1DM, of whom approximately 20% (9300) have hypoglycemia unawareness. RT-CGM was estimated to reduce the cost of annual hypoglycemia-related hospitalizations in this select population by $54 369 000, yielding an estimated net cost savings of $8 799 000 to $12 519 000 and a savings of $946 to $1346 per patient. Conclusion: This article presents a cost calculation based on available data from multiple sources showing that RT-CGM has the potential to reduce short-term health care costs by averting severe hypoglycemic events requiring hospitalization in a select high-risk population. Prospective, randomized studies that are adequately powered and specifically enroll patients at high risk for severe hypoglycemia are needed to confirm that RT-CGM significantly reduces the incidence of these costly events.
MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells
Authors: Lima Cilene Rebouças , Geraldo Murilo Vieira , Fuziwara Cesar Seigi , Kimura Edna Teruko , Santos Marinilce Fagundes 
Published: February 2016

Abstract

Background
Tumor invasiveness is directly related to the ability of tumor cells to migrate and invade surrounding tissues, usually degrading extracellular matrix. Despite significant progress in the knowledge about migration and invasion, there is much more to elucidate about their regulatory mechanisms, especially in cancer cells. MicroRNAs (miRs) were recently described as important regulators of migration. Differential expression of miRs in cancer is frequently associated with progression, invasion and metastasis. In papillary thyroid carcinoma (PTC), miR-146b-5p is highly expressed and positively correlated to the degree of malignancy.

Methods
This study aimed to investigate the role of miR-146b-5p on the migratory and invasive behaviors of thyroid cells, using a non tumor rat thyroid follicular cell line (PCCl3) transfected with the miR-146b-5p genomic region, and two PTC cell lines (TPC-1 and BCPAP, bearing distinct oncogenic backgrounds), which express high levels of miR-146b-5p, after miR-146b inhibition by antagomiR and miR-146b overexpression by mimics-miR. Migration and invasion were studied by time-lapse and transwell assays (with and without Matrigel®). Gelatin degradation assays were also employed, as well as F-actin staining.

Results
Migration and invasion of PCCl3 were increased 2-3x after miR-146b-5p overexpression (10X) and large lamellipodia were evident in those cells. After miR-146b-5p inhibition, TPC-1 and BCPAP migration and invasion were significantly reduced, with cells showing several simultaneous processes and low polarity. Gelatin degradation was inhibited in TPC-1 cells after inhibition of miR-146b-5p, but was unaffected in BCPAP cells, which did not degrade gelatin. The inhibition of miR-146b-5p in PCCl3 also inhibited migration and invasion, and additional (exogenous) overexpression of this miR in TPC-1 and BCPAP cells increased migration and invasion, without effects on cell morphology or gelatin degradation. The overexpression of SMAD4 in BCPAP cells, a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway, inhibited migration similarly to the effects observed with the antagomiR 146b-5p.

Conclusions
miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells (independently from their original mutation, either BRAF or RET/PTC), through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation.
High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs
Authors: Lieblich Samuel M. , Castle David J. , Pantelis Christos , Hopwood Malcolm , Young Allan Hunter , Everall Ian P. 
Published: February 2016

SummaryMajor depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations.
Online screening and feedback to increase help-seeking for
mental health problems: population-based randomised controlled
trial
Authors: Batterham Philip J. , Calear Alison L. , Sunderland Matthew , Carragher Natacha , Brewer Jacqueline L. 
Published: February 2016

BackgroundCommunity-based screening for mental health problems may increase service
use through feedback to individuals about their severity of symptoms and
provision of contacts for appropriate services.AimsThe effect of symptom feedback on service use was assessed. Secondary
outcomes included symptom change and study attrition.MethodUsing online recruitment, 2773 participants completed a comprehensive
survey including screening for depression (n=1366) or
social anxiety (n=1407). Across these two versions,
approximately half (n=1342) of the participants were
then randomly allocated to receive tailored feedback. Participants were
reassessed after 3 months (Australian New Zealand Clinical Trials
Registry ANZCTR12614000324617).ResultsA negative effect of providing social anxiety feedback to individuals was
observed, with significant reductions in professional service use.
Greater attrition and lower intentions to seek help were also observed
after feedback.ConclusionsOnline mental health screening with feedback is not effective for
promoting professional service use. Alternative models of online
screening require further investigation.
Auditory verbal hallucinations in first-episode psychosis: a phenomenological investigation
Authors: Upthegrove Rachel , Ives Jonathan , Broome Matthew R. , Caldwell Kimberly , Wood Stephen J. , Oyebode Femi 
Published: February 2016

BackgroundIn dimensional understanding of psychosis, auditory verbal hallucinations (AVH) are unitary phenomena present on a continuum from non-clinical voice hearing to severe mental illness. There is mixed evidence for this approach and a relative absence of research into subjective experience of AVH in early psychosis.AimsTo conduct primary research into the nature of subjective experience of AVH in first-episode psychosis.MethodA phenomenological study using diary and photo-elicitation qualitative techniques investigating the subjective experience of AVH in 25 young people with first-episode psychosis.ResultsAVH are characterised by: (a) entity, as though from a living being with complex social interchange; and (b) control, exerting authority with ability to influence. AVH are also received with passivity, often accompanied by sensation in other modalities.ConclusionsA modern detailed phenomenological investigation, without presupposition, gives results that echo known descriptive psychopathology. However, novel findings also emerge that may be features of AVH in psychosis not currently captured with standardised measures.
Long-term antipsychotic treatment in schizophrenia: systematic review and network meta-analysis of randomised controlled trials
Authors: Zhao Ying Jiao , Lin Liang , Teng Monica , Khoo Ai Leng , Soh Lay Beng , Furukawa Toshiaki A. , Baldessarini Ross J. , Lim Boon Peng , Sim Kang 
Published: February 2016

BackgroundFor treatment of patients diagnosed with schizophrenia, comparative long-term effectiveness of antipsychotic drugs to reduce relapses when minimising adverse effects is of clinical interest, hence prompting this review.AimsTo evaluate the comparative long-term effectiveness of antipsychotic drugs.MethodWe systematically searched electronic databases for reports of randomised controlled trials (RCTs) of antipsychotic monotherapy aimed at reducing relapse risks in schizophrenia. We conducted network meta-analysis of 18 antipsychotics and placebo.ResultsStudies of 10 177 patients in 56 reports were included; treatment duration averaged 48 weeks (range 4–156). Olanzapine was significantly more effective than chlorpromazine (odds ratio (OR) 0.35, 95% CI 0.14–0.88) or haloperidol (OR=0.50, 95% CI 0.30–0.82); and fluphenazine decanoate was more effective than chlorpromazine (OR=0.31, 95% CI 0.11–0.88) in relapse reduction. Fluphenazine decanoate, haloperidol, haloperidol decanoate and trifluoperazine produced more extrapyramidal adverse effects than olanzapine or quetiapine; and olanzapine was associated with more weight gain than other agents.ConclusionsExcept for apparent superiority of olanzapine and fluphenazine decanoate over chlorpromazine, most agents showed intermediate efficacy for relapse prevention and differences among them were minor. Typical antipsychotics yielded adverse neurological effects, and olanzapine was associated with weight gain. The findings may contribute to evidence-based treatment selection for patients with chronic psychotic disorders.
A’Lelia Walker: The Joy Goddess of Harlem
Authors: Bundles A’Lelia 
Published: February 2016

This essay examines the role A’Lelia Walker played as a fashion and social trendsetter in Harlem during the 1920s. The only daughter of early-twentieth-century hair-care-industry pioneer Madam C. J. Walker, she carved her own niche as a patron of the arts and philanthropist.
An heiress with exquisitely decorated homes and chauffeured cars and hostess of music-filled soirees, she personified the spirit and flamboyance of the era. Always stylish, her blend of regal, statuesque African beauty and haute couture served as an inspiration to poets, painters, and novelists. Among those for whom she posed were photographers Berenice Abbott and Addison Scurlock and sculptors Richmond Barthé and Augusta Savage.
Her parties were legendary. Whether at Villa Lewaro (her mother’s Irvington, New York, mansion), at The Dark Tower (a converted floor of her 136th Street townhouse), or at her 80 Edgecombe Avenue pied-a-terre, she welcomed uptown and downtown artists, musicians, actors, writers, political activists, and socialites.
Langston Hughes called her “the joy goddess of Harlem’s 1920s” because her memorable gatherings lent such a glamorous, glitzy aura to the social scene above 110th Street.
Η άλωση της Θεσσαλονίκης στα 1430 και ο Σέρβος δεσπότης Γεώργιος Μπράνκοβιτς (Djuradj Brankovic)
Authors: Παπανδριανός Ιωάννης Α. 
Published: February 2016

<p>No abstract </p>
Ν. Π. Δελιαλή, Συμβολαί εις την Εκκλησιαστικήν Ιστορίαν της Κοζάνης, Ε'- Τα χαλκά αντικείμενα της Εκκλησίας του Αγίου Νικολάου Κοζάνης, ΣΤ' - Τα οικονομικά της Εκκλησίας του Αγίου Νικολάου Κοζάνης των ετών 1782-1802 (ανάτυπον εκ του Γ' - Δ' τόμου της "Οικοδομής", Επετηρίδος της Ιεράς Μητροπόλεως Σερβίων και Κοζάνης)
Authors: Παπουλίδης Κωνσταντίνος Κ. 
Published: February 2016

<p>No abstract </p>
Αθανασίου Γρ. Γερομιχαλού, Η εθνική δράσις του μητροπολίτου Πελαγονίας Ιωακείμ Φοροπούλου και αι εκθέσεις αυτού
Authors: Παπουλίδης Κωνσταντίνος Κ. 
Published: February 2016

<p>No abstract </p>
Ιωάννου Μ. Φουντούλη, Συμεών, Αρχιεπισκόπου Θεσσαλονίκης, τα λειτουργικά συγγράμματα τ. Ι Ευχαί και ύμνοι
Authors: Παπουλίδης Κωνσταντίνος Κ. 
Published: February 2016

<p>No abstract </p>
Analysis of red autofluorescence (650-670nm) in epidermal cell populations and its potential for distinguishing contributors to 'touch' biological samples
Authors: Stanciu Cristina E. , Philpott M. Katherine , Bustamante Eduardo E. , Kwon Ye Jin , Ehrhardt Christopher J. 
Published: February 2016

Interpretation of touch DNA mixtures poses a significant challenge for forensic caseworking laboratories. Front end techniques that facilitate separation of contributor cell populations before DNA extraction are a way to circumvent this problem. The goal of this study was to survey intrinsic fluorescence of epidermal cells collected from touch surfaces and investigate whether this property could potentially be used to discriminate between contributor cell populations in a biological mixture. Analysis of red autofluorescence (650-670nm) showed that some contributors could be distinguished on this basis. Variation was also observed between autofluorescence profiles of epidermal cell populations from a single contributor sampled on different days. This dataset suggests that red autofluorescence may be a useful marker for identifying distinct cell populations in some mixtures. Future efforts should continue to investigate the extrinsic or intrinsic factors contributing to this signature, and to identify additional biomarkers that could complement this system.
Effect of Multimodal Anesthesia on the Hemodynamic Profile and Acid-Base Balance in the Early Post-Operative Period in Patients Operated for Lung Tumors
Authors: Качур  , Kachur S. , Долгих  , Dolgikh V. 
Published: February 2016

This work presents the effects of multimodal anesthesia with neuraxial blockade on the basic
parameters of central hemodynamics in patients operated for lung tumors, revealed by method of terapolar
rheovasography by Kubicek (systolic blood pressure, diastolic, average heart rate, ejection fraction, minute
volume of blood circulation, cardiac index, oxygen delivery index, the index of the total peripheral vascular
resistance), as well the effects on acid‐base balance of arterial blood in the immediate post‐operative period.
The level of antinociceptive protection was assessed by visual analogue scale. Comparison of results of patients
operated by means of multimodal anesthesia and the patients, operated in an inhalation intravenous
anesthesia with artificial lung ventilation and peri‐operative analgesia by opioid analgesics has revealed that
the hemodynamic profile of the first group of patients is characterized by stability of the basic parameters
such as blood pressure and heart rate, the lack of a pronounced reduction of the ejection fraction and stroke
volume of the heart, despite vasoplegia caused by epidural blockade. The level of partial oxygen tension of
arterial blood was decreased in the early postoperative period, but it was in the normal limits and he was
statistically significantly higher than in the comparison group that can help reduce the risk of post‐operative
complications. Significantly lower level of pain indicates adequate antinociceptive protection of patients.
Humoral Immune Response to Lipopolysaccharides of Enterobacteria in the Young Men 18-19 Years with Different Levels of Adaptation Reserves of Cardio-Respiratory System
Authors: Минина  , Minina E. , Гордиенко  , Gordienko A. 
Published: February 2016

For the first this article time presents the data about the features of humoral immune response
to lipopolysaccharides of enterobacteria in youths with different levels of adaptation reserves, as well as the
possible pathogenetic and compensatory mechanisms of adaptive response to physical stress of sports orientation.
The analysis of correlations between cardio‐respiratory parameters and levels of serum anti‐LPS antibodies
of different classes of athletes in the competitive period and boys in the control group showed a correlation
of serum anti‐LPS‐IgA with autonomic regulation, largely expressed in students, which was accompanied
by an increase in the degree of centralization of management and regulatory mechanisms influence
the sympathetic component of the autonomic regulation. The authors demonstrate the necessity timely correction
and direction of the protective potential of the organism in relation to transient endotoxemia. After
the correction in the period between competitions increase physical performance in athletes by an average of
10.1% was accompanied by a trend towards lower levels of antibodies to enterobacterial lipopolysaccharide
classes of M and G, leveling differences in these parameters relative to boys in the control group, as well as
the lack of correlation relationships between studied parameters, indicating that the adaptive capacity expansion
with a decrease in the limiting factors.
Transcranial Electro-Psychocorrection in the Complex Treatment of Patients with Chronic Hepatitis C
Authors: Афонина  , Afonina E. , Смекалкина  , Smekalkina L. 
Published: February 2016

The article presents the results of authors’ study of diagnosis and treatment of 90 patients with
chronic hepatitis C. The necessity of an organization of effective care of these patients according to combined
mental disadaptation was determined the relevance this study. Hepatitis C and its consequences are powerful
physical and mental stress on the body, occupying one of the leading causes of disability among the population.
Undetected and uncompensated timely signs of disadaptation may increase and eventually be transformed
into forms difficult to treat.
The purpose of this work was to investigate the efficacy of complex treatment of patients using the new
non‐drug technologies of psychocorrection at the stage of a hospital. For comparative analysis, the psychodiagnostic
and electro‐physiological examinations, the study of the adaptation level of and quality of life of
patients were carried out. The use of a level approach to the diagnosis of mental status of patients allows to
optimize the scheme of conventional treatment by differentiated selection of modern psycho‐methods.
The obtained data prove that the combined use of physio‐ and psychotherapy (transcranial electropsychocorrection)
is the most effective method to correct the health the health of patients with viral hepatitis
C. This method can be recommended for inclusion in the system of medical and psycho‐social support to
this contingent.
A Reconsideration of Gender Differences in Risk Attitudes
Authors: Filippin Antonio , Crosetto Paolo 
Published: February 2016

This paper reconsiders the wide agreement that females are more risk averse than males. We survey the existing experimental literature, finding that significance and magnitude of gender differences are task specific. We gather data from 54 replications of the Holt and Laury risk elicitation method, involving about 7,000 subjects. Gender differences appear in less than 10% of the studies and are significant but negligible in magnitude once all the data are pooled. Results are confirmed by structural estimations, which also support a constant relative risk aversion representation of preferences. Gender differences correlate with the presence of a safe option and fixed probabilities in the elicitation method.This paper was accepted by John List, behavioral economics.