bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desktop‐based virtual reality social platforms versus video conferencing platforms for online synchronous learning in higher education: An experimental study to evaluate students' learning gains and user experience
Authors: Di Natale Anna Flavia , Repetto Claudia , Villani Daniela 
Published: October 2024

AbstractBackgroundOnline synchronous learning in higher education frequently struggles to overcome the social presence gap, resulting in dissatisfaction and poor learning outcomes.ObjectivesThis study examined the effectiveness of desktop‐based virtual reality (VR) social platforms compared to video conferencing (VC) platforms in enhancing students' learning gains and experiences in online synchronous learning.MethodsThe study used a within‐subject design, involving 34 college students in two online lecture modules, one via a VR social platform and another through a VC platform. Knowledge assessments occurred pre‐ and post‐modules and after 1 week. Students also completed post‐module questionnaires to evaluate their learning experience, in terms of social presence, easiness of use and perceived emotions. In‐depth interviews provided further insights into their experiences with both platforms.ResultsThe study showed that using VR social platforms for online synchronous learning enhanced immediate knowledge, especially in students less interested in the content, yet it did not notably impact long‐term knowledge retention. Despite no significant findings in social presence from questionnaires, interviews indicated that the VR's heightened interactivity might be offset by the effect of not seeing others' real appearances in promoting social presence. Furthermore, the VC platform was found to be easier to use, attributed to its familiarity and user‐friendliness. Finally, students experienced increased fun, awe and interest, along with reduced boredom, when using the VR social platform.ConclusionThe findings highlight the potential of VR to enrich online learning while underscoring the need for effective strategies facilitating a smooth integration into educational settings.
Community‐Acquired Pressure Injuries: Prevalence, Risk Factors and Effect of Care Bundles—An Integrative Review
Authors: Aloweni Fazila , Lim Siew Hoon , Gunasegaran Nanthakumahrie , Ostbye Truls , Ang Shin Yuh , Siow Kee Chen Elaine 
Published: October 2024

ABSTRACTAim and ObjectivesTo summarise the evidence and present the state of the science on pressure injury care bundles in the community. Specifically, this review examined (i) the extent of pressure injury by studying its prevalence and incidence in the last 10 years, (ii) the risk factors associated with community‐acquired pressure injury and (iii) the components and outcomes associated with effective pressure injury care bundles in the community.BackgroundPI care bundles have effectively reduced PI rates; however, there is limited evidence of care bundles used in community settings.DesignIntegrative review.MethodsThis integrative review is guided by the Whittemore and Knafl framework and follows the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) reporting guidelines. Quality appraisal was applied to assess the quality of selected articles. Data relevant to the review aims were extracted, and findings were synthesised and presented. PubMed, Medline, CINAHL and Web of Science were searched. Studies published in the English language between 2012 and 2022 were retrieved.ResultsA total of 89 articles were retrieved; 25 met the inclusion criteria. Most studies reported the point prevalence and period prevalence of community‐acquired pressure injuries, and only one study reported the incidence of community‐acquired pressure injuries. The point prevalence and period prevalence of community‐acquired pressure injury were 0.02% to 10.8% and 2.7% to 86.4%, respectively, and the cumulative incidence was 1.3%. The risk factors for community‐acquired pressure injury assessed vary between studies; older age, poor nutrition, immobility and multiple comorbidities are commonly reported. Socioeconomic and caregiving factors were not studied. Very few studies evaluated pressure injury care bundles in the community. Even so, the components of the pressure injury care bundle vary between studies.ConclusionsPressure injury development is associated with a complex interplay of factors. Socioeconomic and caregiving factors were not examined in any of the papers. There is a lack of understanding of the components and outcomes associated with effective pressure injury care bundles in the community.Relevance to Clinical Practice

Despite their prevalence, community‐acquired pressure injuries (CAPIs) are often underreported due to inadequate follow‐up and reporting mechanisms.

Although the risk factors for CAPIs vary across studies, older age, impaired mobility, multiple comorbidities and malnutrition consistently emerge as key contributors.

Pressure injury preventive care bundles are more commonly used in the acute care setting rather than the community setting.

Patient or Public ContributionNo Patient or Public Contribution.
Nursing‐Based Sleep Promotion Intervention Effectiveness for Post Cardiac Surgery Patients: Systematic Review
Authors: Hweidi Issa M. , Jebreel Omar H. , Alhawatmeh Hossam N. , Jarrah Mohamad I. , Abu‐Awwad Awwad A. , Hweidi Mohammed I. 
Published: October 2024

ABSTRACTBackgroundSleep is a fundamental prerequisite for physical and mental health. Poor quality of sleep is common among post‐cardiac surgery patients and leads to serious health conditions.ObjectiveTo conduct a systematic review that investigates the effectiveness of eye masks, earplugs and deep‐breathing exercise on sleep quality among post‐cardiac surgery patients.DesignA systematic review of interventional studies was established to meet the PRISMA guidelines.MethodsPRISMA guidelines were used to assess the findings of 11 selected studies that met the inclusion criteria, published between 2007 and 2023 across four databases: CINAHL, JDNR, MEDLINE and PubMed. The search was conducted on 23 November 2023.ResultsThe 11 most eligible studies were analysed. All of them were interventional, encompassing a total of 787 participants. Randomised controlled trials were the most common design. Interventions included eye masks, earplugs and deep‐breathing exercises. The Richards‐Campbell Sleep Questionnaire was the most used assessment scale. Most of the reviewed studies found that the use of non‐pharmacological interventions (eye masks, earplugs and deep‐breathing exercise) significantly improves the quality of sleep. These interventions were also found to have potentially positive effects on reducing pain and delirium experienced by patients after undergoing cardiac surgery.ConclusionsNon‐pharmacological interventions (eye masks, earplugs and deep‐breathing exercise) were found to be cost‐effective interventions that could be easily applied in the clinical setting and are effective in improving the quality of sleep among patients after cardiac surgery.
Boundary Conditions for Organizations in the Anthropocene: A Review of the Planetary Boundaries Framework 10 Years On
Authors: Williams Amanda , Perego Paolo , Whiteman Gail 
Published: October 2024

AbstractWe systematically review business research concerning the planetary boundaries framework: A natural science framework that identifies nine Earth system boundaries that govern the safe operating space for humanity. Ten years after the introduction of the planetary boundaries in business studies, we pose two critical questions: How has the planetary boundaries concept been integrated into business studies and how has research on each of the nine boundaries advanced? Our review demonstrates growing scholarly interest in both questions. However, the topic remains niche with critical gaps, with most studies published in sustainability‐focused journals and only occasionally in mainstream journals. Theoretical development remains fragmented and of greater concern, a systems perspective is lacking in empirical studies: Most articles focus solely on one issue – climate change – and there is almost no cross‐analysis between boundaries. We contrast this with evidence that the planetary pressures of the Anthropocene are approaching dangerous thresholds and make the provocative assertion that planetary boundaries are not simply the foundation for specialized research on corporate sustainability but rather are the necessary boundary conditions for all business studies in the Anthropocene. We call for a transformation in how business scholars theorize, measure and engage.
Salivary Antimicrobial Peptide in Patients With Dementia Before and After Clinical Oral Rehabilitation Programme: A Randomised Controlled Trial
Authors: Chen Ming‐An , Yang Yuan‐Han , Liu Ching‐Kuan , Matsuo Koichiro , Hsu Chih‐Cheng , Lin Ying‐Chu , Huang Hsiao‐Ling 
Published: October 2024

ABSTRACTBackgroundEmerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis.ObjectiveWe investigated the effects of a clinical oral rehabilitation programme tailored for dementia patients on salivary flow rate, AMP levels and oral health‐related quality of life (OHRQoL).MethodsEligible patients were randomly assigned to either the experimental group (EG; n = 28) or the control group (CG; n = 27). Both groups received a leaflet on oral health. In addition, the EG received an oral care intervention that included individual lessons on oral muscle exercises and oral self‐care practices. Saliva samples and OHRQoL data were collected at baseline and follow‐up visits. Generalised estimating equation models were used to analyse the changes over time.ResultsAt the 3‐month follow‐up, EG showed significantly lower histatin 5 (HTN‐5) levels (β = −0.08; effect size [ES] = 0.72) than CG. At 6 months, EG exhibited improved salivary flow rate (β = 0.89; ES = 0.89) and OHRQoL (β = 6.99; ES = 1.31) compared to CG. Changes in salivary flow rate (β = 4.03), HTN‐5 level (β = −0.78) and beta‐defensin 2 level (BD‐2) (β = −0.91) at 3 months predicted improved OHRQoL at 6 months (all p < 0.05).ConclusionsOur clinical oral rehabilitation programme reduced the level of salivary HTN‐5, increased salivary flow rate and enhanced OHRQoL in dementia patients. Furthermore, changes in salivary flow rate, HTN‐5 level and BD‐2 level were associated with improvements in patients' OHRQoL.
Effects of Playing an Interactive Educational App on Children's Learning and Executive Function
Authors: Gao Chunying , Wang Fuxing , Chen Jiaxue , Tong Yu , Chen Yinghe 
Published: October 2024

AbstractChildren are increasingly using educational apps, but little research has been conducted to determine their effectiveness. The current study compared the effect of an interactive touchscreen app to the effect of a noninteractive video about the app on young children's Chinese characters learning and executive functions (EFs). In a mixed between‐within design, 50 children aged 5 to 6 years old were randomly assigned to play the app on touchscreen or to watch a noninteractive video about the app. Results showed that children in the app condition made more progress from the pretest to the posttest in Chinese characters learning, and more improvement in working memory scores and inhibitory capacity scores compared to the video condition. Results suggest that interactive literacy apps on touchscreens benefit children's learning and EFs. Future research should continue to focus on the impact of different forms of touchscreen use on children's executive functioning.
Weak association between total alpha‐synuclein reflex tear levels and non‐motor symptoms burden in Parkinson's disease
Authors: Camacho‐Ordonez Azyadeh , Hernández‐Medrano Ana Jimena , Cervantes‐Arriaga Amin , Rodríguez‐Violante Mayela 
Published: October 2024

AbstractBackgroundAlpha‐synuclein (αSyn) is critical to the pathogenesis of Parkinson's disease (PD). Recognition of non‐motor symptoms as clinical manifestations of PD suggests aggregation of αSyn in extranigral areas.AimThis study aimed to evaluate the association between total αSyn levels in reflex tears with non‐motor symptoms.MethodsThis cross‐sectional study included 25 people living with PD (PwP) and 38 age‐matched healthy controls (HC). Total αSyn reflex tear levels were measured using an enzyme‐linked immunosorbent assay. PwP were evaluated using the Non‐Motor Symptoms Scale (NMSS), the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS), Hoehn and Yahr Stage (HY), and Montreal Cognitive Assessment (MoCA).ResultsTotal αSyn reflex tear levels were significantly higher in PwP when compared with HC (1.77 pg/mL [IQR 1.75–1.79] vs. 1.73 pg/mL [IQR 1.70–1.75], p < 0.001). The urinary domain was negatively correlated with total αSyn levels in tears (r = −0.416, p = 0.048). No correlation was observed between total αSyn levels in reflex tears with MDS‐UPDRS, HY, or MoCA.ConclusionsTotal αSyn levels in reflex tears can differentiate PD from HC. In addition, total αSyn reflex tear levels were associated with the urinary domain of NMSS but are not associated with motor and cognitive symptoms, nor HY. Therefore, our findings suggest that it does not reflect ongoing dopaminergic neurodegeneration.
Structures for quality assurance and measurements for kidney replacement therapies: A multinational study from the ISN‐GKHA
Authors: Ekrikpo Udeme E. , Davidson Bianca , Calice‐Silva Viviane , Karam Sabine , Osman Mohamed A. , Arruebo Silvia , Caskey Fergus J. , Damster Sandrine , Donner Jo‐Ann , Jha Vivekanand , Levin Adeera , Nangaku Masaomi , Saad Syed , Tonelli Marcello , Ye Feng , Okpechi Ikechi G. , Bello Aminu K. , Johnson David W. 
Published: October 2024

AbstractAimOptimal care for patients with kidney failure reduces the risks of adverse health outcomes, including cardiovascular events and death. We evaluated data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN‐GKHA) to assess the capacity for quality service delivery for kidney failure care across countries and regions.MethodWe explored the quality of kidney failure care delivery and the monitoring of quality indicators from data provided by an international survey of stakeholders from countries affiliated with the ISN from July to September 2022.ResultsOne hundred and sixty seven countries participated in the survey, representing about 97.4% of the world's population. In countries where haemodialysis (HD) was available, 81% (n = 134) provided standard HD sessions (three times weekly for 3–4 h per session) to patients. Among countries with peritoneal dialysis (PD) services, 61% (n = 101) were able to provide standard PD care (3–4 exchanges per day). In high‐income countries, 98% (n = 62) reported that >75% of centers regularly monitored dialysis water quality for bacteria compared to 28% (n = 5) of low‐income countries (LICs). Capacity to monitor the administration of immunosuppression drugs was generally available in 21% (n = 4) of LICs, compared to 90% (n = 57) of high‐income countries. There was significant variability between and within regions and country income groups in reporting the quality of services utilized for kidney replacement therapies.ConclusionQuality assurance standards on diagnostic and treatment tools were variable and particularly infrequent in LICs. Standardization of delivered care is essential for improving outcomes for people with kidney failure.image
Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification
Authors: Rees Victoria , Klare Matías , Samaniego Valentina , Leiva Felipe , Jara René , Martínez Rondanelli Benjamín , González Providell Sergio 
Published: October 2024

ABSTRACTObjectiveThe epidemiology of cysts and odontogenic tumors is important for differential diagnosis and treatment strategies. We aimed to describe the epidemiological features of cysts and odontogenic tumors in the Chilean population using the current WHO classification.Materials and MethodsWe reviewed 22,914 biopsy requests received between January 1984 and September 2023 at the oral pathology department, School of Dentistry, Universidad Mayor, Santiago, Chile. Patients diagnosed with cysts of the jaws and odontogenic tumors were selected and information regarding age, sex, and location was recorded.Results4226 (18.4%) were cysts, and 551 (2.4%) were odontogenic tumors, ranging from 2 to 97 years old. Males represented 54.4% and females 45.7% of the total sample. The most prevalent cysts were radicular cysts (58.6%), dentigerous cysts (17.9%), and odontogenic keratocysts (13.3%). The most prevalent odontogenic tumors were odontomas (40.1%) and conventional ameloblastoma (17.6%).ConclusionsOur study was the first retrospective analysis to determine the epidemiological features of both cysts and odontogenic tumors together, based on the 2022 WHO classification. This is relevant as it offers a potential basis for comprehensive comparisons of the epidemiological features of these entities, which could contribute to an accurate differential diagnosis, therefore, leading to more effective therapeutic interventions.
AP1c and SOC1 Form a Regulatory Feedback Loop to Regulate Flowering Time in Soybean
Authors: Li Haiyang , Liao Chunmei , Yang Hui , Kong Lingping , Liu Shuangrong , Wei Jin , Chen Haili , Zhao Xiaohui , Liu Baohui , Kong Fanjiang , Chen Liyu 
Published: October 2024

ABSTRACTFlowering time is a key agronomic trait that directly affects soybean yield. Both APETALA1 (AP1) and SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) regulate flowering time in soybean, but their genetic and regulatory relationships have not been clarified. Here, we report that AP1c physically interacted with two SOC1 proteins, SOC1a and SOC1b, and that these SOC1s upregulated the expression of AP1c, promoting flowering. Moreover, AP1c repressed the expression of the SOC1s by directly binding to their promoters, thus preventing plants from flowering too early. These findings indicate that AP1c and SOC1s form a regulatory feedback loop that regulates flowering time. Importantly, we identified an exceptional allele, AP1cG, that was selected for during soybean domestication and promotes the early‐flowering phenotype in cultivated soybean. Collectively, our work identifies a previously unknown allelic combination potentially useful for both classical and molecular soybean breeding.
Deductive Inference and Mental Agency
Authors: Peacocke Christopher 
Published: October 2024

ABSTRACTTo give a good account of deductive inference, we need to recognise two new relations, one in the realm of contents, the other in the psychological realm of mental action. When these new relations are properly coordinated, they can supply an account of what it is for a thinker to be making a deductive inference. The account endorses the condition that in deductive reasoning, a thinker must take the premises to support the conclusion. The account is distinguished from the positions of Broome, Ryle, and Wright.
Designing a Nurse‐Led eHealth Cardiac Rehabilitation Program: Insights From Participant Experiences and Qualitative Feedback
Authors: Su Jing Jing , Paguio Jenniffer Torralba , Wang Weidi , Batalik Ladislav 
Published: October 2024

AbstractBackgroundThis study examines the perspectives of individuals with coronary heart disease (CHD) on a nurse‐led eHealth cardiac rehabilitation (NeCR) program, which included a website, tele‐monitoring device, and social media chatroom.MethodsUsing a descriptive qualitative approach, semi‐structured interviews were conducted with 18 participants to capture their feedback and experiences with the NeCR program.ResultsParticipants found the NeCR program valuable in addressing gaps in cardiac rehabilitation services in China, empowering them to make behavioral changes and enhancing their social motivation. However, they also highlighted the need for a more user‐friendly website, better symptom management during exercise, and stronger privacy protections in the peer networking chatroom. The study concludes that the NeCR program is feasible in providing accessible rehabilitative services at home post‐discharge. Recommendations include improving the self‐monitoring platform for ease of use, incorporating immediate symptom management guidance during exercise, and ensuring a secure environment for online peer support.ConclusionsThese findings offer crucial insights for developing patient‐centered eHealth cardiac rehabilitation services, emphasizing the importance of user‐friendly design, effective symptom management features, and privacy protection in promoting participant engagement with e‐platforms.Trial RegistrationChiCTR1800020411 (http://www.chictr.org.cn/showprojen.aspx?proj=33906)
Analysis of bleeding outcomes in patients with hypoproliferative thrombocytopenia in the A‐TREAT clinical trial
Authors: Poston Jacqueline N. , Brown Siobhan P. , Ginsburg Amy Sarah , Ilich Anton , Herren Heather , El Kassar Nahed , Triulzi Darrell J. , Key Nigel S. , May Susanne , Gernsheimer Terry B. 
Published: October 2024

AbstractBackgroundDespite prophylactic platelet transfusions, hypoproliferative thrombocytopenia is associated with bleeding; historical risk factors include hematocrit (HCT) 25%, activated partial thromboplastin time 30 s, international normalized ratio 1.2, and platelets5000/μL.MethodsWe performed a post hoc analysis of bleeding outcomes and risk factors in participants with hematologic malignancy and hypoproliferative thrombocytopenia enrolled in the American Trial to Evaluate Tranexamic Acid Therapy in Thrombocytopenia (A‐TREAT) and randomized to receive either tranexamic acid (TXA) or placebo.ResultsWorld Health Organization (WHO) grade 2+ bleeding occurred in 46% of 330 participants, with no difference between the TXA (44%) and placebo (47%) groups (p = 0.66). Overall, the most common sites of bleeding were oronasal (18%), skin (17%), gastrointestinal (11%), and genitourinary (11%). Among participants of childbearing potential, 28% experienced vaginal bleeding. Platelets ≤5000/μL and HCT < 21% (after adjusting for severe thrombocytopenia) were independently associated with increased bleeding risk (HR 3.78, 95% CI 2.16–6.61; HR 2.67, 95% CI 1.35–5.27, respectively). Allogeneic stem cell transplant was associated with nonsignificant increased risk of bleeding versus chemotherapy alone (HR 1.34, 95% CI 0.94–1.91).DiscussionThe overall rate of WHO grade 2+ bleeding was similar to previous reports, albeit with lower rates of gastrointestinal bleeding. Vaginal bleeding was common in participants of childbearing potential. Platelets ≤5000/μL remained a risk factor for bleeding. Regardless of platelet count, bleeding risk increased with HCT < 21%, suggesting a red blood cell transfusion threshold above 21% should be considered to mitigate bleeding. More investigation is needed on strategies to reduce bleeding in this population.