bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carrier‐Free Biomimetic Organic Nanoparticles with Super‐High Drug Loading for Targeted NIR‐II Excitable Triple‐Modal Bioimaging and Phototheranostics
Authors: Liu Ying , Luo Yu , Gao Yijian , Ma Yujie , Huang Zhongming , Yang Yuliang , Li Xiliang , Li Shengliang 
Published: October 2024

AbstractMultimodal near‐infrared II (NIR‐II) theranostics combined with nanotechnology have emerged as promising treatments for cancer due to their noninvasive and high spatiotemporal nature. Traditional NIR‐II theranostics typically comprise useless and massive inert carriers, resulting in low drug loading capacity, reduced therapeutic effects, and potential biotoxicity. To overcome these limitations, this work reports carrier‐free NIR‐II theranostics simultaneously with high drug loading capacity and multimodal NIR‐II imaging capabilities for cancer phototheranostics in the NIR‐II window. Carrier‐free BTA nanoparticles (NPs) are prepared by self‐assembling the NIR‐II responsive conjugated oligomer BTA without adding coating agents; these NPs exhibited 100% drug loading and high‐performance NIR‐II theranostic capabilities. Cancer cell membranes are camouflaged on carrier‐free BTA NPs to provide homologous targeting ability, enhanced stability, and 77.8% drug loading. Both in vitro and in vivo studies have indicated that biomimetic NPs provide efficient triple‐modal guidance for NIR‐II fluorescence, photoacoustic, and photothermal imaging and complete tumor elimination via photothermal therapy (PTT). Additionally, theranostics‐based treatments with good biosecurity are demonstrated. This study contributes a new strategy for the design of high‐drug‐loading NIR‐II theranostics and further promotes the clinical translation of theranostic agents.
Tailoring Li+ Local Coordination Environment of Solid Polymer Electrolytes to Boom Ionic Conductivity
Authors: Zhao Haitao , Zhang Huandi , Zhao Zehua , Shi Xiaowei , Liu Junpeng , Liu Jiamei , Li Lei 
Published: October 2024

AbstractThe low ionic conductivity is the key issue of solid polymer electrolytes (SPEs), hampering their practical application. Great efforts have been devoted to reducing their crystallinity to increase ionic conductivity but ignored their Li+ local coordination environment influence. Here, Li+ local coordination environment tunable poly(vinylidene fluoride‐co‐hexafluoropropylene)‐based solid‐state electrolytes are experimentally realized via d‐cellobiose octaacetate. d‐cellobiose octaacetate competes with anions and polymer chains for coordination of Li+ thorough C═O groups to weaken their coordination of Li+, increase the number of carriers, and strengthen the transport kinetics of Li+, booming the ionic conductivity of SPEs at room temperature. When used in lithium metal symmetric batteries and full batteries, SPEs greatly improve their electrochemical performance at 25 °C. This work clarifies the important influence of Li+ local coordination environment on Li+ transport and provides a promising strategy to improve the ionic conductivity of SPEs.
Engineered Core–Shell SiC@SiO2 Nanofibers for Enhanced Electromagnetic Wave Absorption Performance
Authors: Song Limeng , Wang Linan , Chen Yongqiang , Wu Hongjing , Song Bozhen , Wang Nannan , Guan Li , Wang Hailong , Zhang Rui , Zhu Yanqiu , Xia Yongde , Fan Bingbing 
Published: October 2024

AbstractTo enable SiC material to achieve high electromagnetic wave (EMW) absorption performance, solving its impedance mismatch with EMW is necessary. Therefore, a novel approach is proposed for the precise control of impedance matching by adjusting the shell thickness of SiO2 nanolayers on the surface of SiC nanofibers (NFs). High‐angle annular dark field‐scanning transmission electron microscopy (HAADF‐STEM) reveals the atomic scale oxidation process of SiC, providing fresh insights into the oxidation mechanism. By oxidizing to construct a heterogeneous core–shell structure nanofiber (NF) can effectively lock the incident EMW inside the NF through the generated charges gathered at the interface, forming an electronic barrier that prevents the outward propagation of EMWs. The produced SiC@SiO2 NFs‐3 exhibits exceptional EMW absorption properties, including an impressive minimum reflection loss (RLmin) of −53.09 dB and a broad maximum effective absorption bandwidth (EABmax) of 8.85 GHz. These findings not only deepen understanding of the oxidation mechanism of SiC but also offer valuable insights for further enhancing the EMW absorption capabilities of SiC materials, paving the way for their application in advanced EMW technologies.
Electrolyte‐Salts Regulated Hydrogen‐Bonding Configuration and Interphase Formation Achieving Highly Stable Anode for Rechargeable Aqueous Sodium‐Ion Batteries
Authors: Wang Meijing , Zhao Jiaojiao , Zhang Yangyang , Liu Yunyun , Ji Wei , Xiang Xingde 
Published: October 2024

AbstractHydrogen evolution reactions that cause the alkalization of aqueous electrolytes generally frustrate the structural stability and cycling performance of NaTi2(PO4)3/C anode material for rechargeable aqueous sodium‐ion batteries (ASIBs). Herein, a novel highly concentrated electrolyte with a large hydrogen‐evolution overpotential and hydroxide‐capture ability is rationally established by incorporating a bifunctional Mg(Ac)2 additive into a concentrated NaAc aqueous solution. The highly concentrated electrolyte salts (4m NaAc+3m Mg(Ac)2) favor regulation on hydrogen‐bonding configurations and kinetically shift the hydrogen evolution potential to a lower value of −1.37 V (vs Ag/AgCl). The Mg(Ac)2 additive plays particular roles in spontaneously capturing hydroxide ions generated during hydrogen evolution reactions on anode surfaces and simultaneously forming a protective Mg(OH)2‐like interphase. As a result, the unique electrolyte significantly improves the structural stability and cycling performance of NaTi2(PO4)3/C anode (94.8% capacity retention after 100 cycles at 100 mA·g−1). The effect of salt concentration on hydrogen bonding configurations of aqueous electrolytes is investigated with Raman spectroscopy and FTIR spectroscopy. The interphase is identified by coupling EDS mapping, X‐ray photoelectron spectroscopy, and X‐ray diffraction. This work provides a new strategy for improving the cycling stability of aqueous sodium‐ion batteries.
Polyurethane Vitrimers Engineered with Nitrogen‐Coordinating Cyclic Boronic Diester Bonds for Sustainable Bioelectronics
Authors: Tao Yue , Xue Yu , Wang Fucheng , Shan Liangjie , Ni Zhipeng , Lan Yunting , Zhang Pei , Wang Yafei , Liu Ji 
Published: October 2024

AbstractFlexible bioelectronic devices seamlessly interface with organs and tissues, offering unprecedented opportunity for timely prevention, early diagnosis, and medical therapies. However, the majority of flexible substrates utilized in bioelectronics still encounter significant challenges in terms of recyclability and reprocessing, leading to the accumulation of environmentally and biologically hazardous toxic waste. Here, the study reports the design of recyclable polyurethane (PU) vitrimers engineered with internal boron‐nitrogen coordination bonds that can reversibly dissociate to boronic acids and hydroxyl, or undergo metathesis reaction following an associative pathway. The study demonstrates the capacity of these recyclable PU vitrimers as flexible substrates in various wearable and implantable bioelectronic applications, achieving high‐quality electrophysiological recordings and stimulation. Furthermore, the study establishes a sustainable recycling process by reconstructing a range of bioelectronic devices from the recycled PU vitrimers without compromising the mechanical performance. This closed‐loop approach not only addresses the critical challenge of the reclaiming medical electronic waste but also paves the way for the development of sustainable flexible bioelectronics for healthcare applications.
An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect
Authors: Mo Xiaoyi , Meng Keyu , Li Zehui , Lan Shanwei , Ren Zhengda , Fu Xihong , Li Chenglin , Sun Tiancheng , Xie Denghui , Zhang Zhongmin , Chen Hui‐Jiuan 
Published: October 2024

AbstractHuman parathyroid hormone (1–34) (PTH) exhibits osteoanabolic and osteocatabolic effects, with shorter plasma exposure times favoring bone formation. Subcutaneous injection (SCI) is the conventional delivery route for PTH but faces low delivery efficiency due to limited passive diffusion and the obstruction of the vascular endothelial barrier, leading to prolonged drug exposure times and reduced osteoanabolic effects. In this work, a microcurrent delivery system (MDS) based on multimicrochannel microneedle arrays (MMAs) is proposed, achieving high efficiency and safety for PTH transdermal delivery. The internal microchannels of the MMAs are fabricated using high‐precision 3D printing technology, providing a concentrated and safe electric field that not only accelerates the movement of PTH but also reversibly increases vascular endothelial permeability by regulating the actin cytoskeleton and interendothelial junctions through Ca2+‐dependent cAMP signaling, ultimately promoting PTH absorption and shortening exposure times. The MDS enhances the osteoanabolic effect of PTH in an osteoporosis model by inhibiting osteoclast differentiation on the bone surface compared to SCI. Moreover, histopathological analysis of the skin and organs demonstrated the good safety of PTH delivered by MDS in vivo. In addition to PTH, the MDS shows broad prospects for the high‐efficiency transdermal delivery of macromolecular drugs.
Platinum Nanozyme‐Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment
Authors: Hu Weitong , Shi Shuhan , Xu Yihua , Zhang Yunting , Hu Jingyi , Bian Qiong , Ma Xiaolu , Ye Yuxian , Yang Shengfei , Sheng Xiaoxia , Liang Guang , Zhang Tianyuan , Wu Haibin , Gao Jianqing 
Published: October 2024

AbstractAndrogenetic alopecia (AGA) is a prevalent issue affecting the physical and mental health of individuals but with fewer current treatments. Platinum nanozymes (PtNZs) are known for their excellent ability to reduce and modulate the high oxidative stress environment in AGA pathology. And microneedles are used to overcome the skin barrier due to the poor permeability of PtNZs. Herein, dissolving microneedles loaded with PtNZs (Pt‐MNs) are designed and successfully induced hair regeneration in the AGA model. Pt‐MNs possessed adequate mechanical strength to breach the skin barrier for effective PtNZs delivery. In vivo, PtNZs first reduced reactive oxygen species (ROS) to oxygen, which recovered the AGA pathological environment. And the oxygen then increased oxidative phosphorylation, promoting the differentiation of hair follicle stem cells to achieve hair regeneration. The group treated with Pt‐MNs with a dosing frequency of once every three days achieved faster hair growth than the daily application of the positive drug minoxidil. Further safety experiments showed that the application of Pt‐MNs locally opened temporary and recoverable skin channels, with no retention of Pt in major organs, indicating high safety. In conclusion, this study indicated the potential of Pt‐MNs as an effective method for treating AGA.
Experimental and analytical investigations on bond–slip behavior of steel reinforcement inUHPFRCconsidering yielding
Authors: Wang Dan‐Dan , Li Ying‐Min , Chen Yi , Long Bin , Kang Shao‐Bo , Zhou Shu‐Rong , Preinstorfer Philipp 
Published: October 2024

AbstractThe bond behavior between ultra‐high‐performance fibre‐reinforced concrete (UHPFRC) and steel rebars plays an important role in the load‐bearing capacity and serviceability of structural members. A suitable bond–slip model is essential for predicting the load resistance and deformation capacity of members, after cracking of the UHPFRC. This paper studies the bond strength between ribbed steel bars and the surrounding UHPFRC before and after yielding of the steel reinforcement. To determine the corresponding bond–slip relationship, pull‐out tests, with varying embedment lengths of the reinforcement, namely 2 times and 10 times the rebar diameter, and diameter of reinforcing bars ranging from 10 mm to 16 mm were conducted. The bond stress, strain and slip along the embedment length of the steel rebars were measured by strain gauges and displacement transducers. Based on the test data, a bond stress–slip model was derived before (elastic stage) and after (inelastic stage) yielding of the reinforcement. The slip at the yield point is suggested through theoretical equations. The post‐yield bond–slip model is based on yield bond stress and frictional bond stress. The two‐part model was validated through iterative procedures and is able to predict the applied force, bond stress and strain distribution along the reinforcing bar. A comparison between the test data and analytical results demonstrates a good predictive capacity on the bond behavior of reinforcement in UHPFRC both before and after yielding of the reinforcement.
Out-of-time-ordered-correlators for the pure inverted quartic oscillator: classical chaos meets quantum stability
Authors: Romatschke Paul 
Published: October 2024

Abstract
Out-of-time-ordered-correlators (OTOCs) have been suggested as a means to diagnose chaotic behavior in quantum mechanical systems. Recently, it was found that OTOCs display exponential growth for the inverted quantum harmonic oscillator, mirroring the fact that this system is classically and quantum mechanically unstable. In this work, I study OTOCs for the inverted anharmonic (pure quartic) oscillator in quantum mechanics, finding only oscillatory behavior despite the classically unstable nature of the system. For higher temperature, OTOCs seem to exhibit saturation consistent with a value of –2⟨x2⟩T ⟨p2⟩T at late times. I provide analytic evidence from the spectral zeta-function and the WKB method as well as direct numerical solutions of the Schrödinger equation that the inverted quartic oscillator possesses a real and positive energy eigenspectrum, and normalizable wave-functions.
High energy scattering in the Unitary Toy Model
Authors: Kovner Alex , Levin Eugene , Lublinsky Michael 
Published: October 2024

Abstract
We continue exploring the Unitary Toy Model (UTM) as a playground for high energy collisions in QCD. Our new approach is based on the diagonalization of the evolution Hamiltonian. Part of the spectrum can be identified with intercepts of dressed Pomerons. Analogously to QCD, a multi-Pomeron expansion of the S-matrix is badly divergent asymptotic series. Yet we succeeded to establish resummation procedures resulting in a well behaved S-matrix. In addition the Hamiltonian possesses negative eigenvalues, which dominate the approach of the S-matrix to saturation. We are hopeful that important lessons about BFKL-based Pomeron calculus could be taken from the toy world to real QCD.
Revisiting for maximal flavor violating $$ {Z}_{e\mu}^{\prime } $$ and its phenomenology constraints
Authors: Liu Jia , Song Muyuan , Zhang Haohao 
Published: October 2024

Abstract
Lepton flavor violation (LFV), observed conclusively in neutrino oscillations, remains a pivotal area of investigation due to its absence in the Standard Model (SM). Beyond the Standard Model (BSM) physics explores charged lepton flavor violation (CLFV), particularly through new particle candidates such as the Z′. This article focuses on maximal LFV interactions facilitated by the Z′ boson, specifically targeting its off-diagonal interactions with the first and second generations of charged and neutral leptons. In our ultraviolet (UV) model for the origin of the Z′, inspired by the work of [R.Foot et al., Phys.Rev. D50 (1994) 4571-4580], we utilize the discrete Z2 symmetry to investigate the maximal LFV mediated by the Z′ between the muon (μ) and electron (e) arising from the additional scalars. This symmetry prohibits flavor-conserving interactions between Z′ and μ+μ−, e+e−. In conjunction with collider, (g – 2)μ, (g – 2)e, inverse μ decay, Muonium-to-Antimuonium conversion and LFV decay constraints, we provide forecasts for anticipated limits derived from processes such as νμN → νeμ+e−N in neutrino trident experiments like the DUNE search at the first time. These limits highlight the prospective scope and significance of LFV investigations within these experimental frameworks. Within the mass range of 0.01 GeV to 10 GeV, the most stringent limit arises from $$ \mathcal{B}\left(\mu \to e+X+\gamma \right) $$
B

μ
→
e
+
X
+
γ

when $$ {M}_{Z^{\prime }}<{m}_{\mu } $$

M

Z
′

<

m
μ

, while ∆ae provides effective constraints as $$ {M}_{Z^{\prime }} $$

M

Z
′

approaches 10 GeV. Looking ahead, the proposed Muonium-to-Antimuonium Conversion Experiment (MACE) is expected to impose the most stringent constraints on Muonium-to-Antimuonium oscillation, improving sensitivity by about one order of magnitude against ∆ae.
An intracerebral microdialysis study to determine the neuropharmacokinetics of eribulin in patients with metastatic or primary brain tumors
Authors: Eroglu Zeynep , Synold Timothy , Badie Behnam , Liu An , Chowdhury Arnab , Kilpatrick Julie , Blanchard Suzette , Portnow Jana 
Published: October 2024

Abstract
Purpose
Eribulin is an inhibitor of microtubule dynamics. It is not as highly protein bound as the taxanes and is less vulnerable to extrusion by P-glycoprotein in the blood–brain barrier (BBB). These features predict that eribulin could play an active role in managing brain tumors. Indeed, the small amount of published clinical data indicates eribulin may have some efficacy against breast cancer brain metastases. To better understand the potential of eribulin for treating brain tumors, we performed an intracerebral microdialysis study to determine the neuropharmacokinetics of eribulin in cancer patients undergoing tumor resection.

Methods
After tumor removal, two microdialysis catheters were inserted into peritumoral brain tissue. Approximately 24 h after surgery, a single dose of eribulin 1.4 mg/m2 was administered intravenously. Dialysate samples were collected continuously for 72 h, with plasma samples collected in parallel. Eribulin concentrations were analyzed by tandem mass spectrometry.

Results
Dialysate samples from 12 intracerebral microdialysis catheters placed in 7 study participants were included in the analysis. A statistically significant difference was observed between eribulin concentrations in brain tissue where BBB was disrupted versus intact, with a difference in mean maximum concentrations on log2 scale of 3.37 (std err = 0.59, p-value = 0.005). Nonetheless, overall brain to plasma ratios of eribulin only ranged from 0.13 to 1.99%.

Conclusion
Although we could detect higher concentrations of eribulin in brain tissue where BBB was disrupted, intracerebral eribulin levels were not sufficient to predict eribulin would have consistent clinically meaningful activity against tumors in the brain.

ClinicalTrials.gov Identifier
NCT02338037 (January 9, 2015).
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
Authors: Chung Hye-Jung , Rajan Sharika , Wu Zhichao , Ferrone Christina K. , Raffeld Mark , Lee Ina , Gagan Jeffrey , Dampier Christopher , Abdullaev Zied , Tyagi Manoj , Cimino Patrick. J. , Quezado Martha , Aldape Kenneth 
Published: October 2024

AbstractAstrocytomas that harbor recurrent genomic alterations in MYB or MYBL1 are a group of Pediatric-type diffuse low-grade gliomas that were newly recognized in the 2021 WHO Classification of Tumors of the Central Nervous System. These tumors are described in the WHO classification as harboring fusions in MYB or MYBL1. In this report, we examine 14 consecutive cases in which a MYB or MYBL1 alteration was identified, each with diagnostic confirmation by genome-wide DNA methylation profiling (6 Angiocentric gliomas and 8 Diffuse astrocytomas, MYB- or MYBL1-altered), for their specific genomic alterations in these genes. Using RNA sequencing, we find productive in-frame fusions of the MYB or MYBL1 genes in only 5/14 cases. The remaining 9 cases show genomic alterations that result in truncation of the gene, without evidence of an in-frame fusion partner. Gene expression analysis showed overexpression of the MYB(L1) genes, regardless of the presence of a productive fusion. In addition, QKI, a recognized fusion partner common in angiocentric glioma, was generally up-regulated in these 14 cases, compared to a cohort comprising >1000 CNS tumors of various types, regardless of whether a genomic alteration in QKI was present. Overall, the results show that truncations, in the absence of a productive fusion, of the MYB(L1) genes can likely drive the tumors and have implications for the analysis and diagnosis of Angiocentric glioma and Diffuse astrocytoma, MYB- or MYBL1-altered, especially for cases that are tested on panels designed to focus on fusion detection.
Only incandescent light significantly decreases feeding of Anopheles funestus s.s. (Diptera: Culicidae) mosquitoes under laboratory conditions
Authors: van Zyl Layla , Burke Ashley M. , Koekemoer Lizette L. , Coetzee Bernard W. T. 
Published: October 2024

AbstractRecent work has demonstrated that exposure to artificial light at night (ALAN) may alter mosquito feeding behavior and so must be considered a moderator of vector-borne disease transfer. Anopheles funestus mosquitoes are a primary malaria vector in sub-Saharan Africa, but no study to date has tested the impact of ALAN on their feeding behavior. Here we test if the exposure to commonly used household lights (compact fluorescent lights, light-emitting diodes, and incandescent lights) alters Anopheles funestus feeding. Mated, unfed female mosquitoes were exposed to a light treatment, at the onset of darkness, followed by a blood-feeding assay. The light treatments consisted of a 30-min light pulse of one of the three household lights, each in individual experimental containers, versus controls. All three household lights resulted in a reduction in the percentage of females taking a blood meal, but only mosquitoes exposed to incandescent light showed a statistically significant reduction in feeding of 19.6% relative to controls which showed a 42.8% feeding rate. Our results suggest that exposure to some household lights during the night may have an immediate inhibitory effect on Anopheles funestus feeding. By helping identify which light types lead to a suppression of feeding, the findings of this study could provide insight necessary to design household lights that can help minimize mosquito feeding on humans.
Bone impairment in atypical hemolytic and uremic syndrome treated by long-term eculizumab
Authors: Regnier Maitena , Leclerc Anne-Laure Sellier , Tenenbaum Julie , Desjonqueres Marine , Chavassieux Pascale , Fremeaux-Bacchi Véronique , Farlay Delphine , Bacchetta Justine 
Published: October 2024

AbstractAtypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy, related to complement dysregulation, including Factor H deficiency (FH) treated by lifelong eculizumab therapy. Its long-term tolerance is not yet fully described. We report two patients with genetic FH deficiency receiving long-term eculizumab and displaying a peculiar bone phenotype. First case is a 13-year-old girl, presenting with bone pains, arthritis, and deformities, for which X-rays and MRI described multifocal osteochondritis. Bone biopsy revealed an active remodeling bone (many areas of bone formation and resorption) and C3c accumulation on immunohistochemical staining. The second patient is an 11-year-old girl, displaying mechanical bone pains, for which bone scintigraphy found hypofixation of wrists and ankles. These findings could be consistent with a side effect of eculizumab, as C3c accumulation may result from the downstream C5-blockade. Alternatively, bone alterations could be due to the absence of FH, as described in murine models. Further investigations are required to characterize bone disease in aHUS.