bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrer par le logement pour étudier des pratiques de migrants circulaires
Authors: Chapon Julie , Le Roux Guillaume 
Published: November 2017

<p class="resume">Notre envie de collaborer, à l’occasion de ce séminaire, s’est d’abord appuyée sur la connaissance d’un espace commun, Ouagadougou, à travers des travaux de recherche doctorale (Julie Chapon) et la participation à la mise en place et aux traitements des enquêtes « Mobilités spatiales en Afrique de l’Ouest » réalisées par l’Institut de Recherche pour le Développement (Guillaume Le Roux). Malgré nos thématiques de recherche et nos approches différentes, la mutualisation de nos expériences nous a permis de prendre conscience de ce que nos travaux partagent : la position scientifique dans la manière d’aborder de façon globale les mobilités et la mobilisation de certains concepts et outils, notamment pour envisager les mobilités les plus labiles. </p>
Identification of IFN-γ and IL-27 as Critical Regulators of Respiratory Syncytial Virus–Induced Exacerbation of Allergic Airways Disease in a Mouse Model
Authors: Nguyen Thi Hiep , Maltby Steven , Tay Hock L. , Eyers Fiona , Foster Paul S. , Yang Ming 
Published: November 2017

Abstract
Respiratory syncytial virus (RSV) infection induces asthma exacerbations, which leads to worsening of clinical symptoms and may result in a sustained decline in lung function. Exacerbations are the main cause of morbidity and mortality associated with asthma, and significantly contribute to asthma-associated healthcare costs. Although glucocorticoids are used to manage exacerbations, some patients respond to them poorly. The underlying mechanisms associated with steroid-resistant exacerbations remain largely unknown. We have previously established a mouse model of RSV-induced exacerbation of allergic airways disease, which mimics hallmark clinical features of asthma. In this study, we have identified key roles for macrophage IFN-γ and IL-27 in the regulation of RSV-induced exacerbation of allergic airways disease. Production of IFN-γ and IL-27 was steroid-resistant, and neutralization of IFN-γ or IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflammation. We have previously implicated activation of pulmonary macrophage by TNF-α and/or MCP-1 in the mechanisms of RSV-induced exacerbation. Stimulation of pulmonary macrophages with TNF-α and/or MCP-1 induced expression of both IFN-γ and IL-27. Our findings highlight critical roles for IFN-γ and IL-27, downstream of TNF-α and MCP-1, in the mechanism of RSV-induced exacerbation. Thus, targeting the pathways that these factors activate may be a potential therapeutic approach for virus-induced asthma exacerbations.
Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice
Authors: McGonigle Terence A. , Dwyer Amy R. , Greenland Eloise L. , Scott Naomi M. , Carter Kim W. , Keane Kevin N. , Newsholme Philip , Goodridge Helen S. , Pixley Fiona J. , Hart Prue H. 
Published: November 2017

Abstract
The ability of macrophages to respond to chemoattractants and inflammatory signals is important for their migration to sites of inflammation and immune activity and for host responses to infection. Macrophages differentiated from the bone marrow (BM) of UV-irradiated mice, even after activation with LPS, migrated inefficiently toward CSF-1 and CCL2. When BM cells were harvested from UV-irradiated mice and transplanted into naive mice, the recipient mice (UV-chimeric) had reduced accumulation of elicited monocytes/macrophages in the peritoneal cavity in response to inflammatory thioglycollate or alum. Macrophages differentiating from the BM of UV-chimeric mice also had an inherent reduced ability to migrate toward chemoattractants in vitro, even after LPS activation. Microarray analysis identified reduced reticulon-1 mRNA expressed in macrophages differentiated from the BM of UV-chimeric mice. By using an anti-reticulon-1 Ab, a role for reticulon-1 in macrophage migration toward both CSF-1 and CCL2 was confirmed. Reticulon-1 subcellular localization to the periphery after exposure to CSF-1 for 2.5 min was shown by immunofluorescence microscopy. The proposal that reduced reticulon-1 is responsible for the poor inherent ability of macrophages to respond to chemokine gradients was supported by Western blotting. In summary, skin exposure to erythemal UV radiation can modulate macrophage progenitors in the BM such that their differentiated progeny respond inefficiently to signals to accumulate at sites of inflammation and immunity.
p40 & thyroid transcription factor-1 immunohistochemistry
Authors: Walia Ritika , Jain Deepali , Madan Karan , Sharma Mehar C. , Mathur Sandeep R. , Mohan Anant , Iyer Venkateswaran K. , Kumar Lalit 
Published: November 2017

Background & objectives:
Accurate histopathological subtyping of non-small cell lung carcinoma (NSCLC) is essential for targeted therapeutic agents. Immunohistochemistry (IHC) is helpful in identification of different tumour subtypes. In this study two marker approaches, one each for glandular and squamous cell differentiation was applied to maximize the proportion of accurately subtyped NSCLC not otherwise specified (NOS) tumours on small biopsy samples.

Methods:
Two hundred and sixty three consecutive lung biopsies of primary lung carcinoma were prospectively studied. These were subtyped first morphologically and then by IHC for p40 and thyroid transcription factor-1 (TTF-1). The diagnosis of NSCLC-NOS before and after addition of IHC was evaluated. Results were correlated and validated with morphologically proven cases and matched surgical specimens.

Results:
Based on morphology, only 140 of the 263 (53.2%) cases of NSCLC were characterized, whereas 123 (46.7%) were classified as NSCLC-NOS type. With addition of IHC (p40 and TTF-1), the latter category reduced to 14.4 per cent and a sum of 225 (85.5%) cases were accurately subtyped into squamous cell carcinoma, adenocarcinoma and adenosquamous carcinoma. p40 showed 100 per cent sensitivity and specificity for squamous differentiation whereas TTF-1 showed sensitivity of 85.3 per cent and specificity of 98.1 per cent. Ninety per cent correlation of morphologic subtypes was achieved with matched resected specimens.

Interpretation & conclusions:
Our results showed that an approach of using only a two-antibody panel (p40 and TTF-1) might help in reduction of diagnostic category of NSCLC-NOS significantly and contribute in saving tissue for future molecular testing.
Potential benefit of optimizing atrioventricular & interventricular delays in patients with cardiac resynchronization therapy
Authors: Urbanek Bozena , Kaczmarek Krzysztof , Klimczak Artur , Ruta Jan , Chudzik Michal , Piestrzeniewicz Katarzyna , Ptaszynski Pawel , Wranicz Jerzy Krzysztof 
Published: November 2017

Background & objectives:
The clinical benefit of optimization (OPT) of atrioventricular delay (AVD) and interventricular delay (VVD) in cardiac resynchronization therapy (CRT) remains debatable. This study was aimed to determine the influence of AVD and VVD OPT on selected parameters in patients early after CRT implantation and at mid-term follow up (FU).

Methods:
Fifty two patients (61±10 yr, 23 males) with left bundle branch block, left ventricular ejection fraction (LVEF) ≤35 per cent and heart failure were selected for CRT implantation. Early on the second day (2DFU) after CRT implantation, the patients were assigned to the OPT or the factory setting (FS) group. Haemodynamic and electrical parameters were evaluated at baseline, on 2DFU after CRT and mid-term FU [three-month FU (3MFU)]. Echocardiographic measures were assessed before implantation and at 3MFU. The AVD/VVD was deemed optimal for the highest cardiac output (CO) with impedance cardiography (ICG) monitoring.

Results:
On 2DFU, the AVD was shorter in the OPT group, LV was paced earlier than in FS group and CO was insignificantly higher in OPT group. At 3MFU, improvement of CO was observed only in OPT patients, but the intergroup difference was not significant. At 3MFU in OPT group, reduction of LV in terms of LV end-diastolic diameter (LVeDD), LV end-systolic diameter, LV end-diastolic and systolic volume with the improvement in LVEF was observed. In FS group, only a reduction in LVeDD was present. In OPT group, the paced QRS duration was shorter than in FS group patients.

Interpretation & conclusions:
CRT OPT of AVD and VVD with ICG was associated with a higher CO and better reverse LV remodelling. CO monitoring with ICG is a simple, non-invasive tool to optimize CRT devices.
Molecular & genetic characteristics of Mycobacterium tuberculosis strains circulating in the southern part of West Siberia
Authors: Pasechnik Oksana , Dymova Maya Alexandrovna , Stasenko Vladimir Leonidovich , Blokh Aleksey Igorevich , Tatarintseva Marina Petrovna , Kolesnikova Lyubov Pavlovna , Filipenko Maksim Leonidovich 
Published: November 2017

Background & objectives:
A complicated epidemiological situation characterized by significantly high tuberculosis (TB) morbidity is observed in West Siberia. This study was aimed to investigate the genetic characteristics of Mycobacterium tuberculosis circulating in the southern part of West Siberia (in the Omsk region).

Methods:
From March 2013 to January 2015, 100 isolates of M. tuberculosis were obtained from patients with pulmonary TB living in the Omsk region. Drug susceptibility testing was performed on Lowenstein-Jensen medium (absolute concentration method). Genetic typing of isolates was carried out by variable number tandem repeats of mycobacterial interspersed repetitive units (MIRU-VNTR) typing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The genetic types and characteristics of cluster strains were determined using 15 MIRU-VNTR loci.

Results:
Thirty six VNTR types were found. Twenty six (26.0%) isolates had a unique profile, and the remaining 74 were grouped in 10 clusters containing from 2 to 23 isolates. The Beijing genotype was found in 72 isolates, 61 (85.0%) of which were part of five clusters that included two large clusters containing 23 isolates. Other genetic families, such as Latin-American Mediterranean (LAM, 11.0%), S family (2.0%) and Haarlem (4.0%), were also detected. The genetic family of 11 isolates could not be determined. Six different VNTR profiles were found in these non-classified isolates. Only 16 per cent of isolates were sensitive to anti-TB drugs. The katG315 (94.8%) and rpoB531 (92.2%) mutations were identified in 77 multidrug-resistant M. tuberculosis isolates.

Interpretation & conclusions:
This study showed that the M. tuberculosis population in the Omsk region was heterogeneous. The Beijing genotype predominated and was actively spreading. The findings obtained point to the need for the implementation of more effective preventive measures to stop the spread of drug-resistant M. tuberculosis strains.
Bisphenol A-induced ultrastructural changes in the testes of common marmoset
Authors: Vijaykumar Tushara , Singh Dipty , Vanage Geeta R. , Dhumal Rohit V. , Dighe Vikas D. 
Published: November 2017

Background & objectives:
Bisphenol A (BPA) is an endocrine disruptor that is widely used in the manufacture of polycarbonate plastics, epoxy resins and dental sealants. It is known to have adverse effects on spermatogenesis in rodents. This study was aimed to evaluate the effects of BPA in adult common marmoset owing to its similarities with human spermatogenesis.

Methods:
Sixteen marmosets were divided into four groups (n=4 per group) and given oral doses of BPA (2.5, 12.5 and 25 μg/kg BW/day) for 70 days to cover two spermatogenic cycles, and the control group received only vehicle (honey). Testes were processed for histological and transmission electron microscopy studies.

Results:
Histology of the testis showed sloughing of germ cells into the lumen, increase in interstitial space and vacuolation of Sertoli cell cytoplasm. Ultrastructural analysis of the testis revealed several degenerative effects on the basement membrane, Sertoli cells, Leydig cells and other developing germ cells in the 12.5 and 25 μg/kg BW/day groups as compared to control.

Interpretation & conclusions:
The observed ultrastructural changes caused by BPA in testicular morphology might be indicative of a perturbed sperm production. Considering the genetic and spermatogenic similarities of common marmoset (Callithrix jacchus) and humans, the study findings are of significance. Further studies are, however, needed to elucidate the mechanism of action.
Two databases derived from BGC-Argo float measurements for marine biogeochemical and bio-optical applications
Authors: Organelli Emanuele , Barbieux Marie , Claustre Hervé , Schmechtig Catherine , Poteau Antoine , Bricaud Annick , Boss Emmanuel , Briggs Nathan , Dall'Olmo Giorgio , D'Ortenzio Fabrizio , Leymarie Edouard , Mangin Antoine , Obolensky Grigor , Penkerc'h Christophe , Prieur Louis , Roesler Collin , Serra Romain , Uitz Julia , Xing Xiaogang 
Published: November 2017

Abstract. Since 2012, an array of 105 Biogeochemical-Argo (BGC-Argo) floats has been deployed across the world's oceans to assist in filling observational gaps that are required for characterizing open-ocean environments. Profiles of biogeochemical (chlorophyll and dissolved organic matter) and optical (single-wavelength particulate optical backscattering, downward irradiance at three wavelengths, and photosynthetically available radiation) variables are collected in the upper 1000 m every 1 to 10 days. The database of 9837 vertical profiles collected up to January 2016 is presented and its spatial and temporal coverage is discussed. Each variable is quality controlled with specifically developed procedures and its time series is quality-assessed to identify issues related to biofouling and/or instrument drift. A second database of 5748 profile-derived products within the first optical depth (i.e., the layer of interest for satellite remote sensing) is also presented and its spatiotemporal distribution discussed. This database, devoted to field and remote ocean color applications, includes diffuse attenuation coefficients for downward irradiance at three narrow wavebands and one broad waveband (photosynthetically available radiation), calibrated chlorophyll and fluorescent dissolved organic matter concentrations, and single-wavelength particulate optical backscattering. To demonstrate the applicability of these databases, data within the first optical depth are compared with previously established bio-optical models and used to validate remotely derived bio-optical products. The quality-controlled databases are publicly available from the SEANOE (SEA scieNtific Open data Edition) publisher at https://doi.org/10.17882/49388 and https://doi.org/10.17882/47142 for vertical profiles and products within the first optical depth, respectively.
Promoting Outdoor Recreation and Adventure Tourism on the Russell Fork: An Academic-Community Partnership Report
Authors: Scott Shaunna L. , McSpirit Stephanie , Foley Jason 
Published: November 2017

Abstract
This community note describes a five-year academic-community partnership between a community organization and two universities in Kentucky. It also documents the potential of adventure tourism to help diversify the community’s economy and contribute to the quality of life in the region. While recognizing that adventure tourism cannot make up for the loss of the area’s traditional economic base, the data indicate that adventure tourism can make a positive contribution to the quality of life, environmental quality, and sustainability of the town. A major obstacle to achieving the community organization’s goals to develop adventure tourism has been the failure to get buy-in from local government leaders.
The Contingency of Appalachia on Our Mind: An Exploration of the Self-Perception of Bourgeois Mountain Print Culture, 1870–1890
Authors: Moore Elisabeth Avery 
Published: November 2017

Abstract
The existing literature on the history of Appalachia in the nineteenth century seeks to understand either the evolution of the construction of the mountaineer stereotype or the reality of life in Appalachia during the period. It does not seek to understand how mountaineers conceived of themselves. My study helps fill that gap by analyzing the idea of Appalachia in the minds of middle-class mountaineers. The genesis of the Appalachian stereotype occurred through the various writings of journalists and travel writers from the New England area. These sketches emphasized the exotic nature of mountain life and highlighted the inherent deviance of the mountaineer. Aware of how they were portrayed in mass media, middle-class mountaineers in western North Carolina deliberately rejected this portrayal through local newspapers. Through these media outlets, mountaineers fought to establish a counter-narrative that defined Southern Appalachia as an extension of the New South and its inhabitants as progressive. In the process, these residents struggled to ensure that middle-class imagery represented the still contingent idea of Appalachia in the American consciousness. In their minds, an aspirational progressivism most closely described the true community of the southern mountains, and all other visions of mountain culture were obscene and inaccurate media creations.
Assessing the Likelihood of Seeking Health Care in Rural Kentucky: Applying the Barriers to Help Seeking Scale to Appalachian and Non-Appalachian Undergraduates
Authors: Starcher Rachael Whitley , Geurin Lynn , Shannon Lisa , Whitley Angela 
Published: November 2017

Abstract
Appalachian health is among the worst in the country. Efforts to address the economic and social barriers to medical care have included increasing insurance access, establishment of rural clinics, and recruitment of outside physicians to the region. Rural areas outside Appalachia face similar concrete obstacles; yet, Appalachian health still lags behind its non-Appalachian rural counterparts. This study uses the Barriers to Help Seeking Scale to examine the health behaviors of undergraduates in regional Kentucky universities. Data indicate that students from rural Appalachian backgrounds are less likely to seek health care (P &lt; .05), even with financial and other concrete barriers removed. In fact, cultural emphases on self-reliance (P = .007), resignation (P = .000), concrete barriers and distrust of caregivers (P = .000), and emotional control (P = .018) account for almost half of Appalachian reluctance to seek help (R2 = .477, P = .000). Appalachian health disparities cannot be completely addressed without increased awareness of these utilization concerns.
Intra-Latina Fertility Differentials in the United States
Authors: Ayala María Isabel 
Published: November 2017

AbstractThis study assesses whether Latinas’ ethnic and racial self-identification can predict their number of “children ever born” (CEB) after controlling for cultural, socioeconomic, and demographic factors. Analyzed together, these factors measure the role that existing racial/ethnic structures have on the experiences of Latino subgroups. I pool data from the Fertility Supplement of the Integrated Public Use Microdata Series (IPUMS) Current Population Survey. Following a series of zero-inflated Poisson regressions and controlling for cultural, socioeconomic, and demographic factors, women who ethnically self-identify as Mexican, Puerto Rican, or Central American have more CEB than women who self-identify as Cuban. Simultaneously, Latinas who racially self-identify as white have fewer CEB than nonwhite Latinas. I propose that the different racialized experiences of these groups can help explain these patterns. Moreover, I argue that the results provide empirical evidence of the multicausal explanations for intra-Latina fertility behavior.
Guldi, J. y Armitage, D. (2016). Manifiesto por la Historia (traducción de Galmarini, M. A. The History Manifesto, 2014). Madrid: Editorial Alianza. 292 págs.
Authors: Botí Hernández Juan Jesús , Sáez Giménez David Omar 
Published: November 2017

La edición de Manifiesto por la Historia que aquí reseñamos es una traducción al castellano de Marco Aurelio Galmarini del original publicado en inglés por la Universidad de Cambridge en 2014. Sus autores son Jo Guldi y David Armitage: Jo Guldi es profesora en la Universidad de Brown, en Providence (Estados Unidos), y ha dedicado buena parte de su obra a estudios sobre la historia de Gran Bretaña y, sobre todo, a la política económica. Por su parte, David Armitage es profesor en la Universidad de Harvard, especialista en historia intelectual e historia del mundo.
La edición de Manifiesto por la Historia que aquí reseñamos es una traducción al castellano de Marco Aurelio Galmarini del original publicado en inglés por la Universidad de Cambridge en 2014. Sus autores son Jo Guldi y David Armitage: Jo Guldi es profesora en la Universidad de Brown, en Providence (Estados Unidos), y ha dedicado buena parte de su obra a estudios sobre la historia de Gran Bretaña y, sobre todo, a la política económica. Por su parte, David Armitage es profesor en la Universidad de Harvard, especialista en historia intelectual e historia del mundo.
La subjectivité dans la numérisation : les perspectives des professionnels
Authors: Chalifour Joshua , Park Eun G. , Henry Bruce 
Published: November 2017

L’influence de la subjectivité sur les processus de sélection en matière de numérisation n’a pas encore été étudiée en profondeur. La présente étude traite des facteurs subjectifs qui sous-tendent les choix des professionnels engagés dans des projets de numérisation ; entreprend une réflexion sur la manière dont ils prennent des décisions de sélection et examine dans quelle mesure leurs points de vue influencent les sélections. Des entrevues menées auprès de cinq professionnels des bibliothèques ou centres d’archives révèlent six facteurs subjectifs récurrents. La documentation de l’influence de ces facteurs apporte davantage de clarté, offrant une meilleure compréhension des objets numériques.