bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXTRACT’S PRELIMINARY PHYTOCHEMICAL SCREENING, SOLID CONTENT AND YIELD AND LEAVES’ AND BARK’S PHYSICAL-CHEMICAL PARAMETERS (HUMIDITY AND ASH CONTENT AND BULK DENSITY) OF Cestrum intermedium Sendtn. (Solanaceae)
Authors: SANTOS Rosemar Hoffmann dos , JÚNIOR Edson Hipólito , CORRER Cassyano Januário 
Published: July 2016

A Dexmedetomidina é agonista dos receptores adrenérgicos α2. Apresenta propriedades sedativas e analgésicas. O estudo MENDS (PANDHARIPANDE PP et al; 2007) evidencia seu uso favorável em reduzir “Delirium”. O objetivo desta revisão sistemática foi determinar qual é o papel da Dexmedetomidina no tratamento de “Delirium”. A busca foi realizada no PubMed e Scopus. As pesquisas ocorreram entre o mês de Outubro de 2013 a Maio de 2014, com os descritores: “Dexmedetomidina” e “Delirium”. Todos os estudos primários relacionando Dexmedetomidina e “Delirium” foram selecionados, analisados e incluídos para extração de dados. Foram selecionados artigos em inglês, português e espanhol. A busca eletrônica resultou em 250 citações sendo 26 artigos incluídos. Destes, 25 relatam uso favorável da Dexmedetomidina. As unidades que utilizam esse medicamento são as UTI(s), geral ou cardiológica. O método CAM-ICU continua sendo usado para avaliação de “Delirium”. Os principais efeitos colaterais são: hipotensão e bradicardia. A faixa etária apresentou variação entre os estudos, entre 18 meses até pacientes com mais de 60 anos. A via de administração desse medicamento, no geral, é endovenosa. A Dexmedetomidina foi comparada com Midazolam, Propofol e Lorazepam. Seu uso reduz tempo de ventilação mecânica, tempo de internamento e consequentemente custo para o hospital. Apesar de um número pequeno de estudos com pequenas amostras os estudos mostram que a Dexmedetomidina apresenta melhores resultados em reduzir “Delirium”, seja na presença, incidência e/ou duração, em diversas situações clínicas, nas diversas faixas etárias e em qualquer unidade de terapia intensiva, seja ela UTI geral ou UTI cardiológica.
THE METHOD APPLIED WAS THE QUALITATIVE EVALUATION OF PREPARATIONS OF MENU (AQPC) IN A FOOD AND NUTRITION UNIT (UAN)
Authors: ORTOLAN Amanda Volz , SCHWARZ Kélin 
Published: July 2016

O objetivo deste trabalho foi avaliar qualitativamente o cardápio de uma Unidade de Alimentação e Nutrição (UAN). Para tanto, foi aplicado o método Avaliação Qualitativa das Preparações do Cardápio (AQPC). Como resultados, foi observado que a unidade oferece diariamente vegetais folhosos, porém, também oferece em todos os dias frituras e doces combinados. A unidade também oferece em 93,3% dos dias alimentos ricos em enxofre e baixa oferta de frutas. Concluiu-se que o cardápio da unidade possui falhas no planejamento pela avaliação negativa dos parâmetros citados.
COMPOSIÇÃO E DISTRIBUIÇÃO DO FITOPLÂNCTON EM ÁREAS COSTEIRAS E OCEÂNICAS DA REOIAO SUESTE DO BRASIL
Authors: Brandini Frederico Pereira , Moraes Cristine Louise Braum 
Published: July 2016

Total phytoplankton samples and hydrographical parameters were collected from the surface of 16 stations located in the southeastern sector of the brazilian coast during the autumn cruise of the R/V “ Almirante Saldanha” . The limits of temperature (22 — 25°C) and salinity (35,0 — 37,1 x 10‘s) observed indicated the great influence of the Tropical Water over the sampling area where the oligotrophic condition is certainly due to the low nutrient concentrations of this watermass. Phosphate, nitrate and silicate ranged from 0.0 to 0.63, 1.41 to 5.69 and from 4.10 to 25,25 ftg-at.r1, respectively.The most frequent diatoms were Coscinodiscus spp, Coscinosira sp, Pleurosigma sp, Pseudoeunotia doliolus, Thalassionema nitzschioides, Thalassiothrix frauenfeldii and T. mediterrânea, among 49 species observed. Prorocentrum and Protoperidinium spp dominated the dinoflagellate population although the genus Ceratium was represented by a greater number of species. Cyanophycean cells were abundant in coastal (Anabaena sp) and oceanic (Trichodesmium erythraeum) samples.The phytoplankton community was numerically dominated by nanoplanktonic organisms like phytoflagellates (including monads) and the coccolithophorid Coccolithus huxleyi. The phytoplankton association observed in the present study is typical of oligotrophic warm waters of the Brazil Current. Amostras de fitoplâncton total e parâmetros hidrográficos foram obtidos na superfície de 16 estações localizadas no setor sudeste da costa brasileira durante o outono de 1983. Os limites de temperatura (22 — 25°C) e salinidade (35,0 — 37,1 x10 “) observados indicaram a influência da Água Tropical na área estudada onde as condições oligotróficas são devidas à baixa concentração de nutrientes nessa massa d’água. Fosfato, nitrato e silicato variaram entre 0,0 e 0,63, 1,41 e 5,69, e 4,10 e 25,25 /ig-at.r1, respectivamente.As diatomáceas mais freqüentes foram Coscinodiscus spp, Coscinosira sp, Fleurosigma sp, Pseudoeunotia doliolus, Thalassionema nitszchioides, Thalassiothrix frauenfeldii e T. mediterrânea, dentre as 49 espécies observadas. Prorocentrum e Protoperidinrum spp dominaram a população de dinoflagelados apesar do gênero Ceratium ter apresentado o maior número deespécies. As cianofíceas Anabaena sp e Oscillatoria (=Trichodesmium) erythraeum foram abundantes nas amostras costeiras e oceânicas.A comuindade fitoplanctônica foi numericamente dominada por organismos do nanoplâncton, tais como fitoflagelados (incluindo-se mônadas) e o cocolitoforídeo Coccolithus huxleyi. A associação fitoplanctônica observada no presente trabalho é típica das águas quentes e oligotróficas da Corrente do Brasil.
AMBIENTE DIGITAL DE APRENDIZAGEM: DO DESIGN ÀS PRÁTICAS
Authors: Costa Eglantine Guély 
Published: July 2016

O CRAPEL (Centro de Pesquisas e Práticas Pedagógicas em Línguas) desenvolveu um ambiente digital de aprendizagem com o intuito de reunir elementos característicos dos centros de recursos de línguas para construir um dispositivo autodirigido de inglês. Apresentaremos este ambiente onde comparamos os dados relacionados ao uso do ambiente digital de seis alunos aprendizes no ambiente projetado com trechos de entrevista de aconselhamento pedagógico realizadas com eles. Mostraremos como este ambiente evidencia uma pedagogia da autonomia e procuraremos determinar as alavancas e freios ligados à sua utilização.Traduzido por: Ayumi Nakaba Shibayama e Andrea Sousa dos Santos
Assessment of a Regression Method to Reclassify Deaths Attributable to Heart Failure
Authors: Metcalf Patricia A. , Meyer Michelle L. , Suchindran Chirayath M. , Heiss Gerardo 
Published: July 2016

<p><strong>BACKGROUND: </strong>Evaluation of cause-specific mortality for public health research depends on accurate death certificates and vital records. However, ill-defined causes of death (termed garbage codes), such as heart failure, are often listed as the underlying cause of death. We examined a regression method proposed by Ahern and colleagues for redistributing deaths attributed to heart failure and compared it to a simulation of the regression method by bootstrapping. </p><p><strong>METHODS: </strong>Deaths attributed to heart failure in four U.S. states (Maryland, Minnesota, Mississippi and North Carolina) were redistributed to a set of underlying causes of death using regression models that identified the proportion of deaths for each target code within a given state-age-sex-education group using ICD-10 mortality data. The results were compared with 3,000 bootstrapped samples with replacement regression.</p><p><strong>RESULTS: </strong>The odds of death from heart failure in the population studied increased with age, was higher in whites and lower in decedents with greater than a high school education compared to those with less than high school education. There were 18 (29.0%) subgroups that showed no significant redistribution targets for the Ahern regression method and 28 (45.2%) for the bootstrapped regression method. Ischemic heart disease was a distribution target for 28 (45.2%) of the Ahern regression subgroups and 22 (35.5%) of the bootstrapped regression subgroups. The Ahern regression method and bootstrapped regression methods were discordant in 19 (30.6%) out of the 62 subgroups examined.</p><p><strong>CONCLUSION: </strong>The Ahern regression method tended to redistribute deaths attributed to heart failure to more target groups compared with the bootstrapped regression method. Both the Ahern regression and the bootstrap regression methods were computationally intensive and inefficient, and results appeared to be influenced by the choices of sex-age-education group strata. Other methods such as coarsened exact matching and improvements to the Ahern approach are desirable additions to the tools available to mitigate the impact of garbage codes on the accuracy of death certification.</p>
Treatment of Crohn's-Related Rectovaginal Fistula With Allogeneic Expanded-Adipose Derived Stem Cells: A Phase I–IIa Clinical Trial
Authors: García-Arranz Mariano , Herreros Maria Dolores , González-Gómez Carolina , de la Quintana Paloma , Guadalajara Héctor , Georgiev-Hristov Tihomir , Trébol Jacobo , Garcia-Olmo Damián 
Published: July 2016

AbstractThe aim of this clinical trial was to determine the safety and feasibility of expanded allogeneic adipose-derived stem cells to treat Crohn’s-related rectovaginal fistula (CRRVF). We designed a phase I–II clinical trial (https://ClinicalTrials.gov, NCT00999115) to treat 10 patients with CRRVF. Patients receiving biological therapy during follow-up were excluded. Curettage was performed, and a vaginal or rectal flap was added if the surgeon considered it necessary. The therapeutic protocol included intralesional injection of 20 million stem cells in the vaginal walls (submucosal area) and fistula tract. Healing was evaluated 12 weeks later. If the fistula had not healed, a second dose of 40 million stem cells was administered. Patient follow-up was 52 weeks from last cell injection. Healing was defined as re-epithelialization of both vaginal and rectal sides and absence of vaginal drainage. Cytokines and immunological blood tests were monitored. Serious adverse events or rejection issues were not observed. Five patients were excluded because biologic drugs were required to treat a Crohn's disease flare-up during follow-up. Cytokine profiles and immunotoxicity assays showed no statistically significant alterations. Sixty percent of the nonexcluded patients achieved a complete healing. Expanded allogeneic adipose-derived stem-cell injection is a safe and feasible therapy for treating CRRVF, and the healing success rate seems promising (60%). The results of this trial encourage further exploration into this therapy.SignificanceThis may be the first publication in which allogeneic stem cells to treat rectovaginal fistula in Crohn’s disease seem to be a feasible and safe treatment. Additional studies are necessary to confirm the efficacy profile of the allogeneic stem cells strategy in a controlled design.
High-peak-power sub-nanosecond intracavity KTiOPO4 optical parametric oscillator pumped by a dual-loss modulated laser with acousto-optic modulator and single-walled carbon nanotube
Authors: Qiao Junpeng , Zhao Shengzhi , Yang Kejian , Zhao Jia , Li Guiqiu , Li Dechun , Li Tao , Qiao Wenchao , Lu Jianren , Wang Yonggang , Chu Hongwei , Luan Chao 
Published: July 2016

Abstract
A high-peak-power low-repetition-rate sub-nanosecond intracavity KTiOPO4 (KTP) optical parametric oscillator (OPO) pumped by a doubly Q-switched and mode-locked (QML) YVO4/Nd:YVO4 laser with an acousto-optic modulator (AOM) and a single-walled carbon nanotube saturable absorber (SWCNT-SA) has been demonstrated. A maximum output power of 373 mW at a signal wavelength of 1570 nm was obtained. The smallest pulse width, highest pulse energy, and greatest peak power of mode-locking pulses were estimated to be 119 ps, 124 µJ, and 1.04 MW, respectively, under a maximum incident pump power of 8.3 W and an AOM repetition rate of 2 kHz. This OPO operation paves a simple way to produce eye-safe laser sources at 1570 nm with low repetition rates, small pulse widths, and high peak powers.
The expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma
Authors: Jimbo Naoe , Ohbayashi Chiho , Fujii Tomomi , Takeda Maiko , Mitsui Suguru , Tanaka Yugo , Itoh Tomoo , Maniwa Yoshimasa 
Published: September 2024

AbstractLineage plasticity in small cell lung carcinoma (SCLC) causes therapeutic difficulties. This study aimed to investigate the pathological findings of plasticity in SCLC, focusing on combined SCLC, and elucidate the involvement of YAP1 and other transcription factors. We analysed 100 surgically resected SCLCs through detailed morphological observations and immunohistochemistry for YAP1 and other transcription factors. Component‐by‐component next‐generation sequencing (n = 15 pairs) and immunohistochemistry (n = 35 pairs) were performed on the combined SCLCs. Compared with pure SCLCs (n = 65), combined SCLCs (n = 35) showed a significantly larger size, higher expression of NEUROD1, and higher frequency of double‐positive transcription factors (p = 0.0009, 0.04, and 0.019, respectively). Notably, 34% of the combined SCLCs showed morphological mosaic patterns with unclear boundaries between the SCLC and its partner. Combined SCLCs not only had unique histotypes as partners but also represented different lineage plasticity within the partner. NEUROD1‐dominant combined SCLCs had a significantly higher proportion of adenocarcinomas as partners, whereas POU2F3‐dominant combined SCLCs had a significantly higher proportion of squamous cell carcinomas as partners (p = 0.006 and p = 0.0006, respectively). YAP1 expression in SCLC components was found in 80% of combined SCLCs and 62% of pure SCLCs, often showing mosaic‐like expression. Among the combined SCLCs with component‐specific analysis, the identical TP53 mutation was found in 10 pairs, and the identical Rb1 abnormality was found in 2 pairs. On immunohistochemistry, the same abnormal p53 pattern was found in 34 pairs, and Rb1 loss was found in 24 pairs. In conclusion, combined SCLC shows a variety of pathological plasticity. Although combined SCLC is more plastic than pure SCLC, pure SCLC is also a phenotypically plastic tumour. The morphological mosaic pattern and YAP1 mosaic‐like expression may represent ongoing lineage plasticity. This study also identified the relationship between transcription factors and partners in combined SCLC. Transcription factors may be involved in differentiating specific cell lineages beyond just ‘neuroendocrine’.
Enhancing Built‐In Electric Field via Defect‐Mediated Interfacial Chemical Bond Construction in Chalcogenide Heterojunction for Alcohol Photooxidation Coupled with H2 Production
Authors: Han Yi‐Wen , Chu Yu‐Ting , Ye Lei , Gong Tian‐Jun , Lu Xue‐Bin , Fu Yao 
Published: September 2024

AbstractRationally designing nanostructures based on an adequate understanding of structure‐performance relationships is key for directional charge transfer regulation in heterojunction photocatalysts. A general strategy is developed for synthesizing bifunctional Sv‐chalcogenide/Ti3C2 Schottky junctions (Sv = sulfur vacancies, chalcogenides containing CdS, CdIn2S4, ZnIn2S4, ZnS, CuInS2) featuring a giant built‐in electric field (BIEF) via defect‐mediated heterocomponent anchorage, which consists of sulfur vacancy modulation of chalcogenides and Ti3C2 nanoparticle anchoring at defects via interfacial Metal─Oxygen (M─O) bonds. These heterojunctions have the distinctive interface structure of semicoherent phase boundaries and a directionally aligned BIEF pointing from chalcogenides to Ti3C2. The enhanced BIEF creates an asymmetrical charge distribution, which not only governs the charge migration behavior by enabling charge carrier localization and delocalized electron transport continuity but also regulates the molecular catalytic behavior by optimizing pivotal intermediate adsorption/activation (*Ar‐CH(R2)‐OH in dehydrogenation and H* in H2 evolution) in selective alcohol photooxidation coupled with H2 generation. Encouragingly, Sv‐chalcogenide/Ti3C2 exhibits unprecedented performance (up to 13.34‐fold higher efficiency than unmodulated chalcogenides) and good substrate compatibility for various alcohols. This work demonstrates the synergistic effects of surface electron density control and interfacial interaction modulation in regulating BIEFs, elucidating the substantial impact of reinforced BIEF on carrier transport properties and molecular catalytic behavior.
Unique Energy‐Storage Behavior Driven by High Entropy in Metallic Glasses
Authors: Wang Lingling , Shi Feilong , Shen Yuwen , Fei Ting , Chu Wei , Wang Zheng , Hu Lina 
Published: September 2024

AbstractThe rejuvenation or energy‐storage behavior in metallic glasses (MGs) has been extensively explored for its theoretical and practical significance. However, very limited research focuses on the rejuvenation of high entropy metallic glasses (HEMGs), leaving uncertainties about how configurational entropy influences this process. In this study, cryogenic temperature cycling (CTC) is utilized to unlock the rejuvenation potential of a series of La‐based MGs with different entropy values. Comparative analysis of these MGs reveals that increased entropy boosts the maximum rejuvenation degree from 37% to 65% and widens the range of energy states where rejuvenation occurs. The changed rejuvenation behavior induced by entropy increase, which has never been reported other studies, are related to glass's structures, fragility and coupling degree between β and α relaxations. Besides, a new rejuvenation mechanism is revealed in HEMGs, which differs significantly from unrestricted growth and interconnection of flow units observed in most MGs. The atomic motion in HEMGs is confined within the icosahedral backbone network during CTC. Surprisingly, this local motion can propagate through strong interactions between adjacent atoms, facilitating the activation of α relaxation. These discoveries offer novel approaches to tune energy‐storage behavior of MGs by modulating icosahedral network structures through entropy control.
Piezoelectric Ceramic Hardening Through Defect Distribution Optimization in Multicomponent Systems
Authors: Liu Jianning , Zhang Dongyan , Yan Yangxi , Li Zhimin , Li Fei , Yang Sen 
Published: September 2024

AbstractAcceptor doping is a common method for hardening modified piezoelectric ceramics. The mechanism through which the hardening effect can be improved has been widely studied and verified. However, the effect of defects caused by different valence states of the B‐site ions on the properties of multicomponent piezoelectric ceramics remains to be discussed. Therefore, in this work, a novel Pb(Ni1/3Nb2/3)O3–Pb(In1/2Nb1/2)O3–Pb(Mn1/3Nb1/2)–PbTiO3 quaternary hard ceramic with excellent performance is prepared and studied. The interaction between grain‐boundary defects and defect dipoles is proposed to be the mechanism behind the observed excellent performance. It is found that different types of defects improve the hardening effect in various ways. These results can provide a theoretical basis for the preparation of multicomponent piezoelectric ceramics with better properties.
Novel Type of Non‐Toxic, Degradable, Luminescent Ratiometric Thermometers Based on Dyes Embedded in Disulfide‐Bridged Periodic Mesoporous Organosilica Particles
Authors: Premcheska Simona , Lederer Mirijam , Mohanty Sonali , Alici Ayse , Skirtach Andre G. , Kaczmarek Anna M. 
Published: September 2024

AbstractDespite the excellent thermometric performance of many developed luminescent nanomaterials, their use has not gone beyond proof‐of‐concept in vivo experiments to date. An important issue that needs to be resolved before moving toward true biomedical applications of engineered nanothermometers is their potential toxicity and bioaccumulation in the human body considering the ultimate objective of clinical applications. Since most reported nanothermometers currently are not degradable materials and are mainly based on the incorporation of heavy metal ions, these aspects remain of genuine concern in the fields of nanomedicine, nanobiotechnology, nanotoxicology, and nanopharmacology. This work explores the possibility of designing visible, as well as near‐infrared, emitting luminescent ratiometric nanothermometers based on appropriate organic dye mixtures embedded in hollow disulfide‐bridged periodic mesoporous organosilica (PMO) particles. Such hybrid particles show excellent thermometric performance in the physiological temperature range (20–50 °C), favorable degradability in simulated physiological conditions, as well as no toxicity to healthy normal human dermal fibroblast (NHDF) cells in a wide concentration range. Considering the simplicity of the approach from the synthetic point of view, and the large available library of known fluorescent dyes emitting in various regions of the electromagnetic range, this motif renders a very promising approach to designing novel non‐toxic, decomposable, luminescent ratiometric thermometers.
Effects of Combining Dion‐Jacobson and Ruddlesden‐Popper Spacers on the Photophysics of Quasi‐2D Perovskites
Authors: Einhaus Lisanne M. , Zhang Xiao , Korterik Jeroen P. , Mul Guido , ten Elshof Johan E. , Huijser Annemarie 
Published: September 2024

AbstractQuasi‐2D lead‐halide perovskites consist of conducting inorganic layers with tunable thickness (n) separated by large organic spacer cations. Typically, domains with different n and bandgaps are formed within a single film. Here, the crystallization of the films is tuned by mixing Dion‐Jacobson (DJ) with Ruddlesden‐Popper (RP) spacer cations. Compared to the quasi‐2D perovskite film based on solely the DJ type spacer 1,4‐phenylenedimethylammonium (PDMA), a film with less defects and more vertically aligned crystallization is achieved by addition of the RP type spacer propylammonium (PA). As the film structure plays an important role in the photophysics, time‐resolved photoluminescence (TRPL) and femtosecond transient absorption (TA) are used to investigate the impact of mixing these spacer cations on the dynamics of hot carrier cooling, the occurrence and directionality of energy or electron transfer between the different domains, and the exciton and charge carrier dynamics. Exciton transfer from low‐n to high‐n domains occurs at a favorable faster rate for the PDMA‐based film (0.0640 ps−1) compared to the PA‐based film (0.0365 ps−1), while the mixed spacer film demonstrates intermediate behavior (0.0473 ps−1). This study facilitates the design of advanced materials with optimized photophysical characteristics for a next generation of optoelectronic devices.