bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous Stem Cell Transplantation in Elderly Lymphoma Patients in Their 70s: Outcomes and Analysis
Authors: Sun Lova , Li Shuli , El-Jawahri Areej , Armand Philippe , Dey Bimalangshu R. , Fisher David C. , Jacobsen Eric D. , Jacobson Caron A. , LaCasce Ann S. , McAfee Steven L. , Spitzer Thomas R. , Chen Yi-Bin , DeFilipp Zachariah 
Published: December 2017

Abstract

Background
High-dose chemotherapy and autologous stem cell transplantation (ASCT) can offer durable remission in many patients with relapsed or high-risk lymphoma. However, elderly patients are often not considered ASCT candidates based on age alone.

Subjects, Materials, and Methods
A retrospective analysis of patients ≥70 years of age with a diagnosis of Hodgkin or non-Hodgkin lymphoma receiving ASCT between 2000 and 2016 at two partner institutions was performed. Clinical data were extracted from institutional databases and individual medical records. Multivariate analysis was performed to examine the association of clinical variables with transplant outcomes.

Results
One hundred seven patients were identified. Median age at transplant was 72 years (range, 70–79). The most common lymphoma subtype was diffuse large B-cell (n = 63, 59%). Median time to neutrophil and platelet engraftment were 10 and 12 days, respectively. With a median follow-up for survivors of 20 months following ASCT (range, 6 months to 13.1 years), estimates for 2-year progression-free survival and overall survival were 58% (95% confidence interval [CI], 48%–67%) and 65% (95% CI, 55%–74%), respectively. Two-year estimate for relapse was 34% (95% CI, 25%–44%) and nonrelapse mortality (NRM) was 7% (95% CI, 3%–14%). Multivariate analysis showed that more recent date of transplant was associated with lower NRM. The Hematopoietic Cell Transplantation-Comorbidity Index score was not predictive of NRM in this data set (high-risk vs. low-risk, hazard ratio 3.45, p = .065).

Conclusion
Eligibility for ASCT should be an individualized decision, and age should not be an absolute contraindication to ASCT in healthy elderly patients with lymphoma.

Implications for Practice
Although high-dose chemotherapy and autologous stem cell transplantation (ASCT) can offer durable remission in many patients with relapsed or high-risk lymphoma, elderly patients are often not considered candidates due to concern for excess toxicity and mortality. This retrospective study showed favorable transplant outcomes, including survival and toxicity, in a large cohort of lymphoma patients over 70 years of age who underwent ASCT. Eligibility for ASCT should be an individualized decision, and age should not be an absolute contraindication to ASCT in healthy elderly patients with lymphoma.
A biografia em sua dimensão argumentativa: o fazer-fazer
Authors: Abreu-Aoki Raquel Lima de 
Published: December 2017

<p><span>O Estado Novo foi fértil na reprodução de textos contendo apologias ao regime e ao estadista Getúlio Vargas. Tal estratégia visava a difusão dos valores e ideais estadonovistas. Dentre esses materiais, selecionamos a biografia <em>Getúlio Vargas para crianças</em>, de autoria de Alfredo Barroso, com o objetivo de analisarmos a construção das imagens de Vargas e compreendermos o ideário daquela conjuntura<em>.</em> Ancoramo-nos na teoria Semiolinguística de Patrick Charaudeau, que nos ajudou a compreender: as instâncias de produção do discurso; os parceiros da troca linguageira e seus estatutos; a finalidade do ato comunicativo e as circunstâncias materiais nas quais se realiza o ato linguageiro.</span> </p>
Resenha de Renaissances de la Rhétorique. Perelman aujourd’hui, de Angenot, Bernier & Côté
Authors: Lima Helcira Maria Rodrigues de 
Published: December 2017

<p class="EIDA-caputresumo">Trata-se da resenha da obra <em><span lang="ES-TRAD">Renaissances de la rhétorique. Perelman aujourd’hui, </span></em>organizada por Marc Angenot, Marc André Bernier e Marcel Côté. Tal publicação é fruto de reflexões empreendidas por pesquisadores de diferentes universidades acerca da obra de Perelman, no Colóquio realizado na Universidade de Quebec em Trois-Rivières, em 2012. O livro é constituído de cinco capítulos, sendo quatro destes compostos de dois textos e um deles de três, além de um prefácio e um posfácio, em um total de 13 textos. A partir de diferentes lugares de enunciação, os autores atestam a importância da herança perelmaniana dando ênfase a noções-chave que perpassaram as reflexões do filósofo e se assentaram, em especial, no <em>Tratado da Argumentação: a Nova retórica</em>, livro que constitui o ponto de partida para os debates.</p>
Managing bile duct injuries sustained during cholecystectomies
Authors: Srivastava Vijay Prakash , Agarwal Shwetank , Agarwal Ajai , Sharan Jagadamba 
Published: December 2017

Background: Medical science is a blend of Art and Science. Technology evolved conceived presumably to improve the medical science. Increasing incidence of bile duct injury during laparoscopic cholecystectomies proved otherwise. Multiple factors e.g. cognitive psychology, laparoscopic environment and no proper algorithms to manage, factor may be responsible for these results. To understand properly the mystique, we under took this study.Methods: This study was conducted on 200 cases which underwent laparoscopic cholecystectomies. 12 cases developed bile duct injury during laparoscopic cholecystectomies and 10 cases of bile duct injury sustained through open cholecystectomies were studied in detail results noted and analyzed.Results: All these cases 12/200 laparoscopic cholecystectomy, 10/200 open cholecystectomies were followed up, sign and symptoms noted, USG studies, ERCP stenting, sphincterotomy studies reviewed and sequence of management underlined.Conclusions: Early realisation of bile duct injuries remains the hall mark of she success. Even in cases detected late, conservative procedure and stenting with or without sphincterotomy given relief in number of cases. Finally, if surgery is contemplated Roux-Y-biliary enteric procedure gives much better results.
Role of dilatation of intramural ureter in patients with lower urinary tract symptoms (LUTS) in UVJ and pre UVJ calculus: an observational study
Authors: Krishnappa Narasimhaiah , Khan Asif , Sakranaik Saraswathi 
Published: December 2017

Background: Various literature sources describe three narrowest anatomic spots in the ureter as the most potential points for ureteric calculi to form and these are: the pelvi-ureteric junction (PUJ), the point where the ureters cross over the iliac vessels and the ureterovesical junction (UVJ).Methods: This study included patients who presented with symptomatic obstructing ureteric calculi and who required uretero renoscopic lithotripsy (URSL). The procedure was selected according to stone size, location and degree of impaction.Results: Of the total of 100 patients, 43 were females and 57 were males. 69 patients had Lower Urinary Tract Symptoms and 31 patients had no Lower Urinary Tract Symptoms with the calculi. The age of the patients ranged from 17 years to 65 years and the stone size ranged from 7mm to 15mm. Lower ureteric calculi with LUTS are good indicators.Conclusions: We can approach lower ureteric calculi without use of dilators or 6/7.5ureteroscope in patients with LUTS.
Outcome of laparoscopic total extraperitoneal approach with direct dissection and mesh hernioplasty in the treatment of inguinal hernias
Authors: Hisham Yousef , Ranjith Mannarakkal , Nabeel Thommil Padinjarenalakath , Sidhic Kummankandath Abbas 
Published: December 2017

Background: Laparoscopic inguinal hernia repair has become increasingly popular as an alternative to open surgery. Aim: To evaluate total extraperitoneal repair with direct telescopic dissection and mesh hernioplasty for inguinal hernias.Methods: This study was conducted at General Surgery department the period of 1 year on 30 patients having inguinal hernia.Results: This prospective study included 30 adult patients with primary unilateral inguinal hernia, all of them were males. Age of study patients ranged from 22 to 64 years old. Intraoperatively, 6 patients were presented to have direct inguinal hernia (20%) while 21 patients had indirect inguinal hernia (70%). In 3 patients, combined direct and indirect hernia defects were present (10%). Mean operative time was 99.30±25.13 min. Mean time for analgesia was 3.62±1.57 days. Hospital stay mean was 1.43±0.62 days. The mean time until return to work was 14.1±3.13 days, the mean time of follow up was 7.1±2.2 months. Intra operatively 5 (15%) and post operatively 8 (26.6%)complications were observed.Conclusions: Laparoscopic TEP repair is an excellent alternative to open preperitoneal repair of inguinal hernia. Complication rate was average with other studies while there was no hernia recurrence during the period of follow up.
Role of scoring system in prediction of difficult laparoscopic cholecystectomy
Authors: Rhezhii Delie , Goyal Vikas , Nagpal Nitin , Nemma Shobhit Kumar , Gupta Monica 
Published: December 2017

Background: One of the most common reasons for admission to hospital is cholecystectomy and it has a mortality rate of 0.45% to 6%. Many risk factors have been found to be associated laparoscopic cholecystectomy that make it difficult like advance age, male gender, fever, obesity, previous abdominal surgeries, thick gall bladder lining, distention of bladder, presence of gall stones. There have been different scoring systems in literature that determine the risk of conversion to open cholecystectomy. The aim of present study is to determine the role of scoring system in predicting difficult laparoscopic surgery.Methods: The present prospective study was conducted for a period of 1 year in the Department of Surgery at Guru Gobind Singh Medical College, Faridkot, Punjab. The study included all the patients with symptomatic gall stones reporting to the OPD of the hospital. Patients were categorized into two groups after the surgery. Group I included patients who underwent successfully laparoscopic cholecystectomy and group II included those who were converted into an open case. In this study all the entities were provided with a score. Patients with score less than 4 were grouped as difficult. At the end of the study all the data were analyzed to see how scoring system can predict which patients will have easy or difficult laparoscopic cholecystectomy based on postoperative scoring. All the data was recorded in a tabulated form and analyzed using SPSS software.Results: The present prospective analytical study involved 112 subjects; out of these 94 were males and 18 females. The mean age of subjects was 48.2±3.7 years. There were 98 patients in Group I and 8 patients in group II who had didn’t show presence of peri cholecystic fluid. There was 1 patient in Group I and 5 patients in group II who had peri cholecystic fluid on ultrasound. There were 104 subjects with gall was thickness less than 4 mm. There were 95 patients in Group I and 9 patients in group II who had who had who had bladder wall thickness of less than 4 mm.Conclusions: The scoring tool evaluated in our study is useful in evaluating the risk of conversion of laparoscopic cholecystectomy into open cholecystectomy.
A prospective study to determine the role of routine prophylactic oral calcium and vitamin D supplements in prevention of transient hypocalcaemia after total and near total thyroidectomy
Authors: Nair Kiran Sukumaran , Gamalial Jose , P. S. Rajesh 
Published: December 2017

Background: Transient hypocalcaemia is a frequent complication after total thyroidectomy, and the symptoms are very distressing for the patients. This study is a prospective cohort study to assess the effectiveness of routine postoperative oral calcium and vitamin D supplementation in post thyroidectomy hypocalcaemia.Methods: 135 patients undergoing near total or total thyroidectomy were divided into two groups, exposed and unexposed, based on post-operative calcium and Vitamin D administration. Both groups were followed up at day 3, at discharge and 2 weeks post operatively for the development of hypocalcaemia.Results: Common age group was 31-40 years in both groups. The mean corrected pre-operative serum calcium was 9.06±0.43mg/dl for the exposed and 9.2±0.62mg/dl for the unexposed group (p = 0.12). The mean corrected calcium levels, on third post op day was 8.9±0.61mg/dl for exposed and 8.5±0.69mg/dl for unexposed group p = 0.001), on day of discharge was 9.2±0.56mg/dl for exposed and 9.0±0.48mg/dl for unexposed group (p = 0.019), and at 2 weeks follow-up was 9.5±0.51mg/dl for exposed and 9.2±0.63mg/dl for unexposed group (p = 0.002). Incidence of clinical symptoms of hypocalcaemia in the exposed group was 5.1% and in the unexposed group was 25.9%. Majority of these patients had transient hypo-calcaemic symptoms in the 48-72hr time period after surgery in both the groups.Conclusions: Routine prophylactic oral calcium and Vitamin D supplementation is effective in preventing transient hypocalcaemia following total or near total thyroidectomy.
Causative factors of deep vein thrombosis of lower limb in Indian population
Authors: Khadilkar Reina , Bhatnagar Shubhi P. , Dave Preet 
Published: December 2017

Background: Deep vein thrombosis refers to the formation of an abnormal coagulum within the deep venous system. An accurate diagnosis of DVT is extremely important to prevent potentially fatal acute complications of pulmonary embolism (PE) and long-term complications of post phlebitis syndrome and pulmonary hypertension. There are many causative factors for DVT.Methods: This was a prospective study where 50 cases of DVT were admitted in this centre. Patients were evaluated in terms of causative factors of DVT. These were previous history of DVT, immobility, surgery, smoking, obesity and drugs. Age and gender comparisons were also done. The most common causes were recorded.Results: The most common cause was found to be immobility and post-surgery immobilization which constituted 90 % of the patients in the study. Advanced age and male gender showed a higher incidence of DVT.Conclusions: Early identification of the causes and the risk factors in the development of DVT can reduce the burden of the disease and contribute to its prevention and management.
Trends of Breastfeeding in the United Arab Emirates (UAE)
Authors: Taha Zainab 
Published: December 2017

In 1990, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) declared a “global goal” for protection, promotion and support of breastfeeding (Innocenti Declaration) (WHO/UNICEF 1990). In 1991 health care authorities in the UAE started to implement breastfeeding promotion and support programs across the country. To date, there are ongoing national efforts and investments in these programs including development and update of policies and strategies.This mini review evaluates the trends of infant and child feeding practices in the UAE over the last few decades to assess the progress attributed to the rollout and implementation of breastfeeding promotion programs.Keywords: Breastfeeding, United Arab Emirates, Nutrition.
A superação da desigualdade como forma de empoderar indivíduos: o caso dos alunos da escola Leonor Pires de Macedo em Restinga Sêca/RS
Authors: Santos Elaine dos 
Published: December 2017

A atuação de um projeto de produção textual deflagrou a percepção da carência identitária dos alunos envolvidos. Assim sendo, optou-se pela realização de atividades que pudessem fazê-los (re) conhecer-se como membros de uma família, de uma escola, de uma comunidade. Para tal, foram realizadas visitas e entrevistas com autoridades locais para que os alunos pudessem entender, por exemplo, o funcionamento de alguns setores da Prefeitura Municipal. Considera-se que essas atividades, sempre pautadas pelos relatos orais ou escritos dos alunos, tenham servido para que eles alcançassem uma nova percepção do mundo em que se inserem, fazendo-se autônomos e capazes de intervir em demandas sociais.
A aplicação da Pedagogia Ontopsicológica no desenvolvimento profissional dos jovens
Authors: Gehrke Augusto Roberto , Schaefer Ricardo 
Published: December 2017

Diante da crise da juventude evidenciada na sociedade contemporânea, novas alternativas pedagógicas estão sendo criadas e testadas a fim de restituir aos jovens a possibilidade da autoconstrução responsável enquanto pessoas e profissionais. Buscando analisar e descrever iniciativas já existentes nessa direção, este artigo investiga os resultados da aplicação da pedagogia ontopsicológica nos alunos da Faculdade Antonio Meneghetti que moram na Casa do Estudante, a partir de uma pesquisa empírica que teve como enfoque a dimensão do trabalho e o desenvolvimento profissional dos jovens. Para atingir esse objetivo, adotou-se um questionário com dados qualitativos e quantitativos em 40 alunos que moram na Casa do Estudante situada no Centro Internacional de Arte e Cultura Humanista Recanto Maestro. Os resultados evidenciam que, por meio do trabalho, os jovens desenvolvem uma competência competitiva e habilidades relacionadas à liderança, criando hábitos pessoais e profissionais funcionais ao próprio crescimento e desenvolvendo o protagonismo responsável. A aplicação da pedagogia ontopsicológica contribui para a formação integral do ser humano e pode ser uma real alternativa à crise da juventude que evidenciamos na sociedade contemporânea.
Aplicação da Pedagogia Ontopsicológica nos Projetos da Fundação Antonio Meneghetti: uma análise de conteúdo
Authors: Ribeiro Eloisa Vieira 
Published: December 2017

A Fundação Antonio Meneghetti tem mais de 25 Projetos ativos, que envolvem mais de mil crianças, adolescentes e adultos, sendo Projetos educacionais, culturais, de incentivo à pesquisa, e têm como principal objetivo o desenvolvimento do ser humano. Tais projetos têm como base a Pedagogia Ontopsicológica e sua aplicação nas mais diversas áreas. Para que esses projetos continuem crescendo, ajudem no desenvolvimento de crianças e adolescentes, foi desenvolvida essa pesquisa, que verificou os resultados que a Fundação Antonio Meneghetti e os participantes dos Projetos vem tendo.
KEPRIBADIAN TOKOH DALAM NOVEL MENCARI PEREMPUAN YANG HILANG (KAJIAN PSIKOANALISIS CARL GUSTAV JUNG)
Authors: Septiarini Tri , Sembiring Renni Handayani 
Published: December 2017

Dewasa ini, psikoanalisis yang lazim digunakan sebagai pendekatan penelitian adalah aspek kaidah-kaidah psikologi yang terdapat dalam karya sastra khususnya karakter tokoh-tokoh utama. Novel Mencari Perempuan yang Hilang karya DR. Imad Zaki, alih bahasa oleh Dr. Zuriyati menceritakan kisah pilu seorang wanita yang menghilang dari peradaban karena berat untuk menanggung beban kejahatan ayahnya yang merugikan orang banyak. Penelitian ini bertujuan untuk: (a) mengetahui bagaimana deskripsi tokoh-tokoh utama dalam novel yaitu Dokter Ahlam, Dokter Sholeh dan Abdul Ghani Zahabi; (b) mengetahui bagaimana tingkat kepribadian pada masing-masing tokoh utama; dan (c) mengetahui tipe kepribadian tokoh-tokoh utama dalam novel. Penelitian ini menerapkan analisis isi dengan pendekatan kualitatif. Dokter Sholeh dan dokter Ahlam mempunyai karakter yang positif. Abdul Ghani Zahabi mempunyai karakter kejam. Dokter Sholeh cenderung memiliki tingkatan kepribadian kesadaran dan ketidaksadaran kolektif (persona). Dokter Ahlam cenderung memiliki tingkatan kepribadian kesadaran dan ketidaksadaran kolektif (animus). Dan Abdul Ghani Zahabi cenderung memiliki tingkatan kepribadian ketidaksadaran personal dan ketidaksadaran kolektif (persona, bayangan, dan anima). Dokter Sholeh cenderung termasuk kedalam tipe kepribadian ekstroversi (pemikir, perasa dan intuitif). Dokter Ahlam cenderung termasuk pada tipe kepribadian introversi (perasa dan intuitif). Dan Abdul Ghani Zahabi cenderung termasuk kedalam tipe kepribadian ekstroversi (pemikir dan perasa) dan introversi (pemikir dan intuitif).
Ankyloglossia (Tongue-Tie)—To Snip or Not to Snip: An Integrative Literature Review
Authors: Levkovich Ryndell , Sidebotham Mary , Vaughan Karolyn , Dietsch Elaine 
Published: December 2017

PURPOSE: Ankyloglossia (commonly referred to as tongue-tie), is increasingly being reported as a significant contributory factor to difficulties experienced in establishing the mother–infant breastfeeding relationship. Frenotomy as a management option is contributing to international interest and interdisciplinary controversy. The aim of this article was to identify and examine the evidence in relation to frenotomy to inform practice for newborns diagnosed with symptomatic ankyloglossia.DESIGN: An integrated literature review, informed by Whittemore and Knafl (2005) was used to identify and evaluate contemporary evidence.MAJOR FINDINGS: There is a marked difference in opinion between health disciplines regarding frenotomy as a treatment option for ankyloglossia. There is agreement that support from a trained professional such as a lactation consultant prior to undergoing any invasive procedures to treat ankyloglossia is essential. Controversy persists however as to whether the condition will resolve spontaneously without treatment.CONCLUSION: Although frenotomy does seem to resolve breastfeeding difficulties, little is known regarding long-term consequences for the baby and optimal timing for the procedure. This review indicates a need for education of professionals and standardization of assessment processes along with ongoing research to identify efficacy and optimal timing of frenotomy when used.
The Effect of Eccentric Activity on Glucose Transporter Type 4 in Gastrocnemius Muscle of Streptozotocin-induced Diabetes Mellitus Mice
Authors: Handoko Adelia , Purwanto Bambang , Mustika Arifa 
Published: December 2017

Diabetes mellitus (DM) is a metabolic disorder with increasing mortality rate. Decrease in GLUT-4 levels was found in diabetics resulting in an increase in postprandial blood glucose levels. Various innovative treatment have been developed, one of them is exercise. Exercise is growing fast today, especially eccentric contraction based exercise that potentially increase GLUT-4 muscle’s level. The aim of the present study was to investigate the effect of eccentric activity on glucose transporter type 4 in gastrocnemius muscle of streptozotocin-induced diabetes mellitus mice. Diabetic mice were grouped randomly into 2 groups. One group was given single bout of eccentric excercise by downhill running on 10o degree decline treadmill and the other group was given eccentric activity by downhill running on 0o degree. The GLUT-4 muscle’s level were measured after treadmill. Data obtained from each group were then analyzed using independent t-test, significant results were found (p<0.05). The conclusion of this study is single bout eccentric downhill running activity with 10o angel increases the levels of GLUT-4 muscles.
Key words: Glucose Transporter Type 4, eccentric, Diabetes Mellitus, Muscle