bluuebunny/crossref_metadata_2025_split huggingface dataset:
SPLF – les liens entre fragilité et pathologies mentales chez la personne âgée
Authors: Arbus C. 
Published: November 2015

La fragilité, aujourd’hui définie selon les critères de Fried et al. [1], est souvent associée à une souffrance psychique et notamment aux symptômes dépressifs ou même à la dépression. S’agit-il d’une co-occurrence ou bien existe-t-il des liens physiopathologiques plus ténus ? De nombreuses études ont rapporté une association positive entre dépression et risque de morbidité et de mortalité [2]. La présence de symptômes dépressifs chez les fragiles aggrave-t-elle le risque de morbidité et de mortalité de ces patients ? Les maladies mentales sont des facteurs de handicap et de vulnérabilité. Il n’existe, à ce jour, aucune étude s’étant intéressée aux populations psychiatriques vieillies au regard du concept de fragilité utilisé en gériatrie. Il existe dans ce domaine un vaste champ de recherche encore inexploré. Il est des situations au cours desquelles apparaissent des syndromes démentiels et la question de la co-occurrence d’une maladie neurodégénérative ou celle d’une évolution vésanique de la maladie psychiatrique se pose [3]. Il n’existe que peu, voire pas, d’études prospectives au long cours permettant de répondre à cette question. Les personnes âgées sont surexposées aux traitements psychotropes. Il s’agit de molécules qui auront de façon quasi-obligatoire des effets délétères, les personnes âgées étant beaucoup plus vulnérables aux effets secondaires de ces traitements alors que leur efficacité dans cette population est souvent difficile à démontrer. Une personne sur deux de plus de 70 ans fait usage de psychotropes en France. La iatrogénie est bien sûr importante avec des risques de chutes et de confusion ou de sédation excessive [4]. Il s’agit de molécules à fort potentiel cognitif. Dans une situation de fragilité gériatrique et lorsque coexiste une symptomatologie psychiatrique, la prescription des psychotropes viendra nécessairement aggraver le pronostic fonctionnel des patients notamment lorsque cette prescription n’est pas maîtrisée et répond à des critères de mésusage.
La matrice ACT et son intérêt thérapeutique immédiat dans la relation thérapeutique
Authors: Vincent J.-M. 
Published: November 2015

Je suis psychiatre libéral à Besançon, je me forme aux TCC depuis 2003, j’ai rencontré en chemin en 2008 la 3e vague des TCC (thérapies cognitives et comportementales) et l’ACT (Acceptance and Commitment Therapy) qui fait partie du courant des psychothérapies contextuelles au sein de cette 3e vague des TCC. J’introduis le modèle de l’ACT depuis dans ma pratique avec tous mes patients. La perspective de la matrice ACT permet d’instaurer un échange thérapeutique fonctionnel avec le patient dès la première séance de thérapie. Ce qui peut nous empêcher d’avancer dans notre vie, ce sont des aspects douloureux de notre expérience intérieure avec lesquels nous allons beaucoup batailler. Cette lutte peut impacter des secteurs importants de notre vie, entraînant une détresse qui se rajoutant à la souffrance va rendre plus forte encore notre douleur intérieure et renforcer encore cette lutte, c’est le piège de l’évitement expérientiel qui se referme alors. Moins éviter a été le pari et la réussite des TCC 1re et 2e vague. Avancer plus et du coup moins éviter est le pari des thérapies de la 3e vague dont la thérapie ACT fait partie. L’ACT propose d’entraîner des habiletés complémentaires qui sont la pleine conscience et la reprise de contact avec les valeurs de vie. Cette reprise de contact avec les valeurs de vie, la thérapie ACT en fait une habileté fonctionnelle décisive. Avec le cas clinique de Sylvie, qui est une belle histoire thérapeutique qui se poursuit bien, j’ai voulu témoigner comment cette reprise de contact avec ses valeurs de vie a été un tournant dans sa thérapie. Le modèle fonctionnel intuitif de la matrice ACT que le thérapeute partage avec son patient est une nouvelle façon de faire de l’ACT qui a aidé et aide encore beaucoup Sylvie à avancer dans sa vie.
Experiencing haptic roughness promotes empathy
Authors: Wang Chen , Zhu Rui (Juliet) , Handy Todd C. 
Published: November 2015

AbstractEliciting empathy plays a significant role in encouraging charitable donations. However, we know little about how incidental, contextual cues can facilitate empathy. In a series of behavioral, neuroscience, and field studies, we show that incidental exposure to haptic sensation of roughness (vs. smoothness) increases individuals' attention to the unfortunate others. Such heightened attention subsequently leads to enhanced empathic responses. These findings not only underscore the power of subtle contextual cues on shaping important behaviors but also point to the possibility of developing novel intervention strategies for promoting empathy and prosociality.
L’élément politique des crimes contre l’humanité: État des lieux de la jurisprudence de la Cour pénale internationale
Authors: HAMULI KABUMBA YVES 
Published: November 2015

AbstractTo be characterized as a crime against humanity under Article 7 of the Rome Statute of the International Criminal Court (ICC), the acts listed must have been committed as part of a systematic or widespread attack in furtherance of a State or organizational policy. Both variants of the attack, that is to say its “systematic” or “generalized” nature are alternative requirements. However, some of the legal literature since the preparatory work to draft the Rome Statute of the International Criminal Court in 1998 considers that the requirement of a policy makes both variants cumulative, hence creating a conflict between Article 7(1) and Article 7(2) of the Rome Statute. The controversy over the content and the legal scope of the concept of policy is worsened by the absence of definitions of the notions of policy and systematic attack in the core legal texts of the ICC. What definition have Chambers of the ICC given to the notion of policy? What sources have Chambers relied on? Does ICC case law provide tools to avoid possible conflict between Article 7(1) and Article 7(2) of the Rome Statute? These are the issues this study attempts to examine.
The Right of Overflight above International Straits
Authors: LALONDE SUZANNE 
Published: November 2015

AbstractThe legal status of the Northwest Passage (NWP) has been the subject of much debate in academic, government, and media circles. To date, much of this discussion has centred on the legal regime governing maritime navigation. However, the question of whether the NWP is subject to guaranteed freedoms or Canada’s unqualified sovereign control also involves the right of overflight. This article investigates the circumstances that led to the inclusion of the freedom of overflight in Part III of the United Nations Convention on the Law of the Sea. It then highlights some of the legal standards that would govern air navigation if the NWP were to be considered an international strait.
No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial
Authors: Knorr Ulla , Koefoed Pernille , Soendergaard Mia H. Greisen , Vinberg Maj , Gether Ulrik , Gluud Christian , Wetterslev Jørn , Winkel Per , Kessing Lars V. 
Published: November 2015

ObjectiveBrain-derived neurotrophic factor (BDNF) seems to play an important role in the course of depression including the response to antidepressants in patients with depression. We aimed to study the effect of an antidepressant intervention on peripheral BDNF in healthy individuals with a family history of depression.MethodsWe measured changes in BDNF messenger RNA (mRNA) expression and whole-blood BDNF levels in 80 healthy first-degree relatives of patients with depression randomly allocated to receive daily tablets of escitalopram 10 mg versus placebo for 4 weeks.ResultsWe found no statistically significant difference between the escitalopram and the placebo group in the change in BDNF mRNA expression and whole-blood BDNF levels.Post hocanalyses showed a statistically significant negative correlation between plasma escitalopram concentration and change in whole-blood BDNF levels in the escitalopram-treated group.ConclusionThe results of this randomised trial suggest that escitalopram 10 mg has no effect on peripheral BDNF levels in healthy individuals.
STRONGLY -ADDITIVE FUNCTIONS AND DISTRIBUTIONAL PROPERTIES OF THE LARGEST PRIME FACTOR
Authors: AMRI M. , MKAOUAR M. , WANNES W. 
Published: November 2015

Let $P(n)$ denote the largest prime factor of an integer $n\geq 2$. In this paper, we study the distribution of the sequence $\{f(P(n)):n\geq 1\}$ over the set of congruence classes modulo an integer $b\geq 2$, where $f$ is a strongly $q$-additive integer-valued function (that is, $f(aq^{j}+b)=f(a)+f(b),$ with $(a,b,j)\in \mathbb{N}^{3}$, $0\leq b<q^{j}$). We also show that the sequence $\{{\it\alpha}P(n):n\geq 1,f(P(n))\equiv a\;(\text{mod}~b)\}$ is uniformly distributed modulo 1 if and only if ${\it\alpha}\in \mathbb{R}\!\setminus \!\mathbb{Q}$.
Geomorphic control of rain-forest floristic composition in French Guiana: more than a soil filtering effect?
Authors: Guitet Stéphane , Freycon Vincent , Brunaux Olivier , Pélissier Raphaël , Sabatier Daniel , Couteron Pierre 
Published: November 2015

Abstract:The influence of geomorphological features on rain-forest diversity has been reported in different Amazonian regions. Soil filtering is often assumed to underlie the observed geomorphic control on the floristic composition but other hypotheses related to biogeography or long-term forest dynamics are also possible. We tested relationships between geomorphology, soil properties and forest composition in French Guiana rain forest using a recent geomorphological map and a large dataset comprising 3132 0.2-ha plots and 421 soil cores. Soil properties were characterized by laboratory analyses and by field descriptions indicating drainage capacity and classification according to the World Reference Base (WRB). The influence of soils and geomorphology on beta-diversity was tested using variance partitioning and ANOVA-like tests. Our results confirm the hypothesis of a strong relationship between geomorphological landscapes and soil properties. Soil filtering significantly influenced the abundance of more than 40 species or groups of species. However geomorphic control of forest composition involves much more than the effects of the soil, which only explain a minor part of the broad-scale patterns of forest diversity related to geomorphological landscapes. These results reinforce the alternative hypotheses linking geomorphological landscapes to long-term forest change under the control of historical processes that shaped forest diversity.
Treatment-emergent sexual dysfunction in randomized trials of vortioxetine for major depressive disorder or generalized anxiety disorder: a pooled analysis
Authors: Jacobsen Paula L. , Mahableshwarkar Atul R. , Palo William A. , Chen Yinzhong , Dragheim Marianne , Clayton Anita H. 
Published: November 2015

ObjectiveAntidepressants are frequently associated with treatment-emergent sexual dysfunction (TESD). Vortioxetine, which was approved for patients with major depressive disorder (MDD), has a receptor profile that suggests limited impact on sexual functioning.MethodsArizona Sexual Experiences Scale (ASEX) patient-level data were pooled from 7 short-term vortioxetine trials (6 in MDD, 1 in generalized anxiety disorder) and analyzed for incidence of TESD at any post-baseline visit in patients without sexual dysfunction at baseline (defined as ASEX total score ≥19; individual ASEX item score ≥5; or a score ≥4 on any 3 ASEX items). The primary objective was to confirm the non-inferiority of vortioxetine 5–20 mg/day to placebo on the incidence of TESD. Comparisons were based on the common risk difference (95% confidence interval). Additional analyses compared vortioxetine to duloxetine and duloxetine to placebo. A sensitivity analysis, defined as TESD at 2 consecutive post-baseline visits, was conducted.ResultsTESD incidence, relative to placebo, generally increased with vortioxetine dose with vortioxetine 5 mg non-inferior to placebo. Vortioxetine 10, 15, and 20 mg did not meet the non-inferiority criterion, but no dose had a significantly higher risk of developing TESD versus placebo. Changes in ASEX individual item scores supported the similarity of vortioxetine doses to placebo. Significantly higher TESD risk occurred with duloxetine 60 mg/day versus placebo and versus vortioxetine 5 or 10 mg. The sensitivity analysis was generally consistent with the primary analysis. Rates of spontaneously reported sexual adverse events were low.ConclusionsVortioxetine was associated with rates of TESD that were not significantly different from placebo in short-term clinical trials.
Lockwood Kipling's Role and the Establishment of the Mayo School of Art (1875–1898)
Authors: KAMRAN TAHIR 
Published: November 2015

AbstractThis article sets out to delineate the process that led to the establishment of Mayo School of Arts in Lahore in 1875. It lays down the context within which the plan to set up art institutions in India was conceived. Contrary to Krishnan Kumar's view whereby the coloniser and the colonised constituted an adult-child relationship the coloniser, in that particular relationship took the role of the adult whereas the native became the child which had been a salient feature of the educational and academic landscape of British India. By challenging Krishna Kumar, this article while drawing on the inferences of Partha Mitter and Hussain Ahmad Khan, argues that in the realm of art instruction the analysis of colonial strategies of adjustment and readjustment provide useful insights about the administrative constraints and cognitive failures of the colonial administrators in the nineteenth-Century Punjab. Challenges like space-selection for MSA campus, appropriate Curriculum for the students and their inadequate language skills stared its founder Principal Lockwood Kipling (1837–19011) in the face. This forms the major focus of the article.
Sodium sources in the Japanese diet: difference between generations and sexes
Authors: Asakura Keiko , Uechi Ken , Masayasu Shizuko , Sasaki Satoshi 
Published: November 2015

AbstractObjectiveGlobally, the Na consumption of most people exceeds the WHO recommendation. To be effective, salt reduction programmes require assessment of the dietary sources of Na. Due to methodological difficulties however, comprehensive assessments are rare. Here, we identified Na sources in the Japanese diet using a 4 d diet record that was specifically designed for Na source description.DesignA cross-sectional study.SubjectsApparently healthy men (n 196) and women (n 196) aged 20–69 years.SettingThe subjects were recruited from twenty-three of forty-seven prefectures in Japan.ResultsThe proportion of discretionary Na intake in total Na intake was 52·3 % in men and 57·1 % in women, and was significantly lower in younger subjects. The two major food groups contributing to Na intake were seasonings such as salt or soya sauce (61·7 % of total Na intake in men, 62·9 % in women) and fish and shellfish (6·7 % in men, 6·6 % in women). The third major contributor differed between men and women (noodles in men, 4·9 %; bread in women, 5·0 %). Further, the contribution of each food group to total Na intake differed among age groups.ConclusionsWhile individual efforts to decrease Na intake remain important, population approaches to reducing Na content in processed foods are already equally important and will assume greater importance in the future even in Japan, an Asian country facing a rapid Westernization in dietary habits.
Why do people with chronic disease not contact consumer health organisations? A survey of general practice patients
Authors: Boyle Frances M. , Dean Julie H. , Young Charlotte E. , Mutch Allyson J. 
Published: November 2015

AimConsumer health organisations (CHOs) are non-profit or voluntary sector organisations that promote and represent the interests of patients and carers affected by particular conditions. The purpose of this study was to examine, among patients with chronic disease, what differentiates those who contact CHOs from those who do not and what stops people from making contact.BackgroundCHOs can enhance people’s capacity to manage chronic disease by providing information, education and psychosocial support, but are under-utilised. Little is known about barriers to access.MethodsData were from a baseline telephone survey conducted as part of a randomised trial of an intervention to improve access to CHOs. Participants constituted a consecutive sample of 276 adults with diagnosed chronic disease recruited via 18 general practitioners in Brisbane, Australia. Quantitative survey items examined participants’ use and perceptions of CHOs and a single open-ended question explored barriers to CHO use. Multiple logistic regression and thematic analysis were used.FindingsOverall, 39% of participants had ever contacted a CHO for their health and 28% had contacted a CHO specifically focussed on their diagnosed chronic condition. Diabetes, poorer self-reported physical health and greater health system contact were significantly associated with CHO contact. The view that ‘my doctor does it all’ was prevalent and, together with a belief that their health problems were ‘not serious enough’, was the primary reason patients did not make contact.ConclusionAttitudinal and system-related barriers limit use of CHOs by those for whom they are designed. Developing referral pathways to CHOs and promoting awareness about what they offer is needed to improve access.
Optimal reinsurance under multiple attribute decision making
Authors: Bulut Karageyik Başak , Dickson David C.M. 
Published: November 2015

AbstractWe apply methods from multiple attribute decision making (MADM) to the problem of selecting an optimal reinsurance level. In particular, we apply the Technique for Order of Preference by Similarity to Ideal Solution method with Mahalanobis distance. We consider the classical risk model under a reinsurance arrangement – either excess of loss or proportional – and we consider scenarios that have the same finite time ruin probability. For each of these scenarios we calculate three quantities: released capital, expected profit and expected utility of resulting wealth. Using these inputs, we apply MADM to find optimal retention levels. We compare and contrast our findings with those when decisions are based on a single attribute.
The effect of microbial colonization on the host proteome varies by gastrointestinal location
Authors: Lichtman Joshua S , Alsentzer Emily , Jaffe Mia , Sprockett Daniel , Masutani Evan , Ikwa Elvis , Fragiadakis Gabriela K , Clifford David , Huang Bevan Emma , Sonnenburg Justin L , Huang Kerwyn Casey , Elias Joshua E 
Published: November 2015

Abstract
Endogenous intestinal microbiota have wide-ranging and largely uncharacterized effects on host physiology. Here, we used reverse-phase liquid chromatography-coupled tandem mass spectrometry to define the mouse intestinal proteome in the stomach, jejunum, ileum, cecum and proximal colon under three colonization states: germ-free (GF), monocolonized with Bacteroides thetaiotaomicron and conventionally raised (CR). Our analysis revealed distinct proteomic abundance profiles along the gastrointestinal (GI) tract. Unsupervised clustering showed that host protein abundance primarily depended on GI location rather than colonization state and specific proteins and functions that defined these locations were identified by random forest classifications. K-means clustering of protein abundance across locations revealed substantial differences in host protein production between CR mice relative to GF and monocolonized mice. Finally, comparison with fecal proteomic data sets suggested that the identities of stool proteins are not biased to any region of the GI tract, but are substantially impacted by the microbiota in the distal colon.
Erratum: Enrichment of DNRA bacteria in a continuous culture
Authors: van den Berg Eveline M , van Dongen Udo , Abbas Ben , van Loosdrecht Mark C M 
Published: November 2015

Abstract
Correction to: The ISME Journal (2015) 9, 2153–2161; doi:10.1038/ismej.2015.26; published online 24 April 2015 Since the publication of this paper, the author has noticed an error in the third paragraph of Materials and Methods (under ‘Chemostat reactor operation’). It should read as follows (changes are underlined):
On the decline of biodiversity due to area loss
Authors: Keil Petr , Storch David , Jetz Walter 
Published: November 2015

AbstractPredictions of how different facets of biodiversity decline with habitat loss are broadly needed, yet challenging. Here we provide theory and a global empirical evaluation to address this challenge. We show that extinction estimates based on endemics–area and backward species–area relationships are complementary, and the crucial difference comprises the geometry of area loss. Across three taxa on four continents, the relative loss of species, and of phylogenetic and functional diversity, is highest when habitable area disappears inward from the edge of a region, lower when it disappears from the centre outwards, and lowest when area is lost at random. In inward destruction, species loss is almost proportional to area loss, although the decline in phylogenetic and functional diversity is less severe. These trends are explained by the geometry of species ranges and the shape of phylogenetic and functional trees, which may allow baseline predictions of biodiversity decline for underexplored taxa.
Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney
Authors: Roy Angshumoy , Kumar Vijetha , Zorman Barry , Fang Erica , Haines Katherine M. , Doddapaneni HarshaVardhan , Hampton Oliver A. , White Simon , Bavle Abhishek A. , Patel Nimesh R. , Eldin Karen W. , John Hicks M. , Rakheja Dinesh , Leavey Patrick J. , Skapek Stephen X. , Amatruda James F. , Nuchtern Jed G. , Chintagumpala Murali M. , Wheeler David A. , Plon Sharon E. , Sumazin Pavel , Parsons D. Williams 
Published: November 2015

AbstractThe X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a variant polycomb repressive complex (PRC) that is mutated or translocated in human cancers. Here we report on the identification of somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR in 23 of 27 (85%) pediatric clear cell sarcomas of the kidney (CCSK) from two independent cohorts. We profile CCSK tumours using a combination of whole-exome, transcriptome and targeted sequencing. Identical ITD mutations are found in primary and relapsed tumour pairs but not in adjacent normal kidney or blood. Mutant BCOR transcripts and proteins are markedly upregulated in ITD-positive tumours. Transcriptome analysis of ITD-positive CCSKs reveals enrichment for PRC2-regulated genes and similarity to undifferentiated sarcomas harbouring BCOR–CCNB3 fusions. The discovery of recurrent BCOR ITDs defines a major oncogenic event in this childhood sarcoma with significant implications for diagnostic and therapeutic approaches to this tumour.