bluuebunny/crossref_metadata_2025_split huggingface dataset:
Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010
Authors: Yang Wei , Carmichael Suzan L. , Shaw Gary M. 
Published: May 2016

BackgroundWe examined whether prevalences of neural tube defects (NTDs), orofacial clefts, and gastroschisis changed more rapidly after than before folic acid fortification in California.MethodsThis population‐based study used vital statistics and birth defects registry data. The study population included all live births and stillbirths delivered in central California counties from 1989 to 2010. Cases included deliveries with NTDs, orofacial clefts, and gastroschisis. Weighted least squares regression was used to estimate slopes during prefortification (before 1997) and postfortification (after 1998), respectively. The difference of the two slopes with the 95% confidence interval (CI) was calculated.ResultsFor all NTDs combined, slopes indicated that NTD prevalence was decreasing by 8.7 (slope: ‐8.7; 95% CI, ‐13.5–−3.9) cases per 100,000 deliveries per year before fortification and by 1.7 (slope: ‐1.7; 95% CI, ‐3.7–0.3) after fortification; thus the decline had slowed by 7.0 (95% CI, 2.7–11.3) cases per 100,000 deliveries per year. For orofacial clefts, slopes for cleft lip with/without palate as well as for cleft palate alone indicated that the postfortification slope was lower than the prefortification slope suggesting a more accelerated decrease in the postfortification time period. For gastroschisis, the slope after fortification was lower compared with prefortification, indicating a less accelerated prevalence increase in the postfortification time period. Stratification by race/ethnicity did not substantially alter results.ConclusionWe observed a slower decline in prevalence of NTDs, an emergence of a decline in orofacial clefts, and a slower increase in gastroschisis, during the postfortification period in central California, relative to the prefortification period. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. Birth Defects Research (Part A) 106:1032–1041, 2016. © 2016 Wiley Periodicals, Inc.
Laboratory course on Streptomyces genetics and secondary metabolism
Authors: Siitonen Vilja , Räty Kaj , Metsä‐Ketelä Mikko 
Published: May 2016

AbstractThe “Streptomyces genetics and secondary metabolism” laboratory course gives an introduction to the versatile soil dwelling Gram‐positive bacteria Streptomyces and their secondary metabolism. The course combines genetic modification of Streptomyces; growing of the strain and protoplast preparation, plasmid isolation by alkaline lysis and phenol precipitation, digestions, and ligations prior to protoplast transformation, as well as investigating the secondary metabolites produced by the strains. Thus, the course is a combination of microbiology, molecular biology, and chemistry. After the course the students should understand the relationship between genes, proteins, and the produced metabolites. © 2016 by The International Union of Biochemistry and Molecular Biology, 44(5):492–499, 2016.
Bone density and depressive disorder: a meta‐analysis
Authors: Schweiger Julietta Ursula , Schweiger Ulrich , Hüppe Michael , Kahl Kai G. , Greggersen Wiebke , Fassbinder Eva 
Published: May 2016

AbstractBackgroundThe aim of this study was to evaluate the evidence of low bone mineral density (BMD) in depression. Low BMD is a major risk factor for osteoporotic fractures and frailty.MethodsThe searched database was Pubmed, Meta‐analysis included human studies in men and women fulfilling the following criteria: (1) assessment of BMD in the lumbar spine, the femur or the total hip; (2) comparison of BMD between depressed individuals and the healthy control group; (3) measurement of BMD using dual‐energy X‐ray absorptiometry (DEXA); and (4) data on the mean, standard deviation, or standard error of BMD.ResultsTwenty‐one studies were identified, encompassing 1842 depressed and 17,401 nondepressed individuals. Significant negative composite weighted mean effect sizes were identified for the lumbar spine (d = −0.15, 95%CL −0.22 to −0.08), femur (d = −0.34, 95%CL −0.64 to −0.05), and total hip (d = −0.14, 95%CL −0.23 to −0.05) indicating low BMD in depression. Examining men and women shows low bone density in the lumbar spine and femur in women and low bone density in the hip in men. The differences between men and women with MDD and the comparison group tended to be higher when examined by expert interviewers. Low bone density was found in all age groups.ConclusionsBone mineral density is reduced in patients with depressive disorders. The studies provide little evidence for potential relevant mediating factors.
A Single Gene Cluster for Chalcomycins and Aldgamycins: Genetic Basis for Bifurcation of Their Biosynthesis
Authors: Tang Xiao‐Long , Dai Ping , Gao Hao , Wang Chuan‐Xi , Chen Guo‐Dong , Hong Kui , Hu Dan , Yao Xin‐Sheng 
Published: May 2016

AbstractAldgamycins are 16‐membered macrolide antibiotics with a rare branched‐chain sugar d‐aldgarose or decarboxylated d‐aldgarose at C‐5. In our efforts to clone the gene cluster for aldgamycins from a marine‐derived Streptomyces sp. HK‐2006‐1 capable of producing both aldgamycins and chalcomycins, we found that both are biosynthesized from a single gene cluster. Whole‐genome sequencing combined with gene disruption established the entire gene cluster of aldgamycins: nine new genes are incorporated with the previously identified chalcomycin gene cluster. Functional analysis of these genes revealed that almDI/almDII, (encoding α/β subunits of pyruvate dehydrogenase) triggers the biosynthesis of aldgamycins, whereas almCI (encoding an oxidoreductase) initiates chalcomycins biosynthesis. This is the first report that aldgamycins and chalcomycins are derived from a single gene cluster and of the genetic basis for bifurcation in their biosynthesis.
Induction of epithelial to mesenchymal transition (EMT) and inhibition on adipogenesis: Two different sides of the same coin? Feasible roles and mechanisms of transforming growth factor β1 (TGF‐β1) in age‐related thymic involution
Authors: Tan Jianxin , Wang Yajun , Zhang Nannan , Zhu Xike 
Published: May 2016

AbstractAge‐related thymic involution is characterized by a loss of thymic epithelial cells (TECs) and a concomitant increase in adipocytes, but the mechanisms involved in thymic adipogenesis are still not clear. Transforming growth factor β1 (TGF‐β1) is a pleiotropic cytokine that has been reported to be up‐regulated with age in thymic stromal cells in both human and mouse. However, the exact role of TGF‐β1 in age‐related thymic involution remains to be further elucidated. On the basis of previous findings, we propose a novel hypothesis that TGF‐β1 functions a dual role in age‐related thymic involution. On one hand, up‐regulation of TGF‐β1 promotes epithelial to mesenchymal transition (EMT) process in TECs via activating forkhead box protein C2 (FoxC2). On the other hand, TGF‐β1 inhibits the transdifferentiation of EMT‐derived mesenchymal cells to adipocytes in the thymus. If confirmed, our hypothesis will not only provide further evidence supporting that the transdifferentiation of TECs into pre‐adipocytes represents a source of thymic adiposity during age‐related thymic involution, but also uncover a unique role of TGF‐β1 in the transdifferentiation of TECs into pre‐adipocytes. Collectively, the inhibition of TGF‐β1 may serve as a strategy to hinder age‐related thymic involution or even to restore thymic function in the elderly.
Autophagy in cardiac metabolic control: Novel mechanisms for cardiovascular disorders
Authors: Yang Yufei , Zhao Cong , Yang Pingzhen , Wang Xianbao , Wang Lizi , Chen Aihua 
Published: May 2016

AbstractAs an extensively studied quality control system, autophagy is responsible for clearance of dysfunctional organelles and damaged marcomolecules in cells. In addition to its biological recycling function, autophagy plays a significant role in the pathogenesis of metabolic syndromes such as obesity and diabetes. In particular, metabolic disorders contribute to cardiovascular disease development. As energy required to maintain cardiac cells functional is immense, disturbances in the balance between anabolic and catabolic metabolism possibly contribute to cardiovascular disorders. Therefore, an urgent need to expand our knowledge on the role of autophagy on the metabolic regulation of hearts emerges. In this review, the potential relationship between autophagic activity and cardiac metabolism is explored and we also discuss how dysregulated autophagy leads to severe cardiac disorders from the perspective of metabolic control.
Facile P−C/C−H Bond‐Cleavage Reactivity of Nickel Bis(diphosphine) Complexes
Authors: Zhang Shaoguang , Li Haixia , Appel Aaron M. , Hall Michael B. , Bullock R. Morris 
Published: May 2016

AbstractUnusual cleavage of P−C and C−H bonds of the P2N2 ligand, in heteroleptic [Ni(P2N2)(diphosphine)]2+ complexes under mild conditions, results in the formation of an iminium formyl nickelate featuring a C,P,P‐tridentate coordination mode. The structures of both the heteroleptic [Ni(P2N2)(diphosphine)]2+ complexes and the resulting iminium formyl nickelate have been characterized by NMR spectroscopy and single‐crystal X‐ray diffraction analysis. Density functional theory (DFT) calculations were employed to investigate the mechanism of the P−C/C−H bond cleavage, which involves C−H bond cleavage, hydride rotation, Ni−C/P−H bond formation, and P−C bond cleavage.
Rhodium(I)‐Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles
Authors: Li Xiaoxun , Xie Haibo , Fu Xiaoning , Liu Ji‐tian , Wang Hao‐yuan , Xi Bao‐min , Liu Peng , Xu Xiufang , Tang Weiping 
Published: May 2016

AbstractA de novo synthesis of a benzene ring allows for the preparation of a diverse range of heterocycles including indoles, benzofurans, benzothiophenes, carbazoles, and dibenzofurans from simple heteroaryl propargylic esters using a unified carbonylative benzannulation strategy. Multiple substituents can be easily introduced to the C4–C7 positions of indoles and related heterocycles.
Highly Enantioselective Formation of α‐Allyl‐α‐Arylcyclopentanones via Pd‐Catalysed Decarboxylative Asymmetric Allylic Alkylation
Authors: Akula Ramulu , Doran Robert , Guiry Patrick J. 
Published: May 2016

AbstractA highly enantioselective Pd‐catalysed decarboxylative asymmetric allylic alkylation of cyclopentanone derived α‐aryl‐β‐keto esters employing the (R,R)‐ANDEN‐phenyl Trost ligand has been developed. The product (S)‐α‐allyl‐α‐arylcyclopentanones were obtained in excellent yields and enantioselectivities (up to >99.9 % ee). This represents one of the most highly enantioselective formations of an all‐carbon quaternary stereogenic center reported to date. This reaction was demonstrated on a 4.0 mmol scale without any deterioration of enantioselectivity and was exploited as the key enantioselective transformation in an asymmetric formal synthesis of the natural product (+)‐tanikolide.
[Ag20{S2P(OR)2}12]: A Superatom Complex with a Chiral Metallic Core and High Potential for Isomerism
Authors: Dhayal Rajendra S. , Lin Yan‐Ru , Liao Jian‐Hong , Chen Yuan‐Jang , Liu Yu‐Chiao , Chiang Ming‐Hsi , Kahlal Samia , Saillard Jean‐Yves , Liu C. W. 
Published: May 2016

AbstractThe synthesis and structural determination of a silver nanocluster [Ag20{S2P(OiPr)2}12] (2), which contains an intrinsic chiral metallic core, is produced by reduction of one silver ion from the eight‐electron superatom complex [Ag21{S2P(OiPr)2}12](PF6) (1) by borohydrides. Single‐crystal X‐ray analysis displays an Ag20 core of pseudo C3 symmetry comprising a silver‐centered Ag13 icosahedron capped by seven silver atoms. Its n‐propyl derivative, [Ag20{S2P(OnPr)2}12] (3), can also be prepared by the treatment of silver(I) salts and dithiophosphates in a stoichiometric ratio in the presence of excess amount of [BH4]−. Crystal structure analyses reveal that the capping silver‐atom positions relative to their icosahedral core are distinctly different in 2 and 3 and generate isomeric, chiral Ag20 cores. Both Ag20 clusters display an emission maximum in the near IR region. DFT calculations are consistent with a description within the superatom model of an 8‐electron [Ag13]5+ core protected by a [Ag7{S2P(OR)2}12]5− external shell. Two additional structural variations are predicted by DFT, showing the potential for isomerism in such [Ag20{S2P(OR)2}12] species.
ChemInform Abstract: Furo(2,3‐d)thiazoles.
Authors: UHER M. , LESKO J. , TOTH I. 
Published: May 2016

AbstractThe acylisothiocyanates (I) add to the 2‐alkoxycarbonyl‐5‐aminofurans(II) to give the N‐furyl‐N'‐acylthioureas (III), which cyclize in the presence of Br2 to yield the furothiazoles (IV), whose formation probably proceeds via the corresponding sulphenyl bromides.
ChemInform Abstract: A Highly Efficient Synthesis of Bicyclo(n.3.1) Ring Systems by AlleneIntramolecular Cycloaddition: Tandem Intramolecular (2 + 2) Cycloaddition ‐ (3.3)‐Sigmatropic Rearrangement.
Authors: HAYAKAWA K. , OHSUKI S. , KANEMATSU K. 
Published: May 2016

AbstractThe propargyl ethers (I) are cyclized in the presence of tert‐butylate producing (II) and (III).
ChemInform Abstract: Synthesis of 4‐Hydroxymethylene‐1,3(2H,4H)‐isoquinolinedione and Related Compounds.
Authors: HIGASHIYAMA K. , TOYAMA M. , OTOMASU H. 
Published: May 2016

AbstractDie Isochinolindione (I) reagieren nach Vilsmeier‐Haack zu den Hydroxymethylenderivaten (II), die über ihre Chloride (III) in die Methoxymethylenisochinolindione (IV) übergeführt werden.
ChemInform Abstract: Transition Metal‐Substituted Diphosphenes. Part 2. Transition Metal‐Induced CO‐Insertion in the P=P Bond of Diphosphenes with Formation of Diphosphinomethanone Derivatives.
Authors: WEBER L. , REIZIG K. , BOESE R. 
Published: May 2016

AbstractThe Fe‐ or Ru‐substituted diphosphenes (I) react with Fe2(CO)9 to give via the intermediary isolable dimetal‐substituted derivatives (II) the P‐metalated diphosphinomethanone compounds (III).
ChemInform Abstract: Synthetic Studies Directed Toward the Naturally Occurring Acyl Tetramic Acids. Part 1. Convergent Total Synthesis of (.+‐.)‐Tirandamycin A
Authors: BOECKMAN R. K. JUN. , STARRETT J. E. JUN. , NICKELL D. G. , SUM P.‐E. 
Published: May 2016

Abstract(XIII).
ChemInform Abstract: Chemistry of Colloidal Manganese Oxides. Part 3. Formation in the Reaction of Hydroxyl Radicals with Mn2+ Ions.
Authors: BARAL S. , LUME‐PEREIRA C. , JANATA E. , HENGLEIN A. 
Published: May 2016

AbstractN2O‐saturated aqueous solutions of Mn(ClO4)2 have been γ‐irradiated and the colloidal manganese oxides formed have been investigated using conductometric and optical techniques.
ChemInform Abstract: Synthesis and Silver Ion Catalyzed Reactions of 3,3′‐Ethylenebicyclopropenyl.
Authors: PEELEN F. C. , LANDHEER I. J. , DE WOLF W. H. , BICKELHAUPT F. 
Published: May 2016

AbstractThe title compound (VI) is obtained from the cyclobutane (I) via double bond addition of dibromocarbene to the dimethylenecyclobutane (III).
ChemInform Abstract: Synthesis and Structure‐Activity Relationship Studies of a Series of 5‐Aryl‐4,6‐dithianonanedioic Acids and Related Compounds: A Novel Class of Leukotriene Antagonists.
Authors: PERCHONOCK C. D. , UZINSKAS I. , MCCARTHY M. E. , ERHARD K. F. , GLEASON J. G. , WASSERMAN M. A. , MUCCITELLI R. M. , DEVAN J. F. , TUCKER S. S. , VICKERY L. M. , KIRCHNER T. , WEICHMAN B. M. , MONG S. , SCOTT M. O. , CHI‐ROSSO G. , WU H.‐L. , CROOKE S. T. , NEWTON J. F. 
Published: May 2016

AbstractDithiaalkanedioic acids such as (IV), (V) and (VII) are prepared, starting with the alkynes (I) and the aromatic aldehydes (VI) respectively.
ChemInform Abstract: Thromboxane A2 Synthase Inhibitors. 5‐(3‐Pyridylmethyl)benzofuran‐2‐ carboxylic Acids.
Authors: JOHNSON R. A. , NIDY E. G. , AIKEN J. W. , CRITTENDEN N. J. , GORMAN R. R. 
Published: May 2016

AbstractThe preparation of the pyridyl derivatives (I) ‐ (IV) is described.
ChemInform Abstract: Thiono and Dithio Esters. Part 40. (2 + 4) Cycloadditions of Dimethyl Tetrathiooxalate to Cyclic Conjugated Polyunsaturated Systems.
Authors: GILLMANN T. , HARTKE K. 
Published: May 2016

AbstractDimethyl tetrathiooxalate (I) reacts with cyclooctatetraene (II), cycloheptatriene (IV), the pentafulvenes (VII) and the naphthoquinone (XI) predominantly as a 4π component to form the (2 + 4) cycloadducts (III), (V), (VI), (VIII), (IX) or (XII).
ChemInform Abstract: Synthesis and Characterization of Four Vanadium(II) Compounds, Including Vanadium(II) Sulfate Hexahydrate and Vanadium(II) Saccharinates.
Authors: COTTON F. A. , FALVELLO L. R. , LLUSAR R. , LIBBY E. , MURILLO C. A. , SCHWOTZER W. 
Published: May 2016

AbstractV(II) sulfate hexahydrate, electrochemically prepared from VOSO4·2 H2O (yield 85%), reacts with sodium saccharinate dihydrate in water at 0 °C to yield the bis(saccharinato)‐V(II) complex (I) as a dihydrate.
ChemInform Abstract: Reactions of TaCl5, MoCl5, and WCl6 with Bis(trimethylsilyl)carbodiimide.
Authors: RAJCA G. , WEIDLEIN J. 
Published: May 2016

AbstractTaCl5 reacts with the carbodiimid (I) in a 1:1 molar ratio to give 1 mol Me3SiCl and the dimeric compound (II), whereas in the 1:1 molar interaction of WCl6 and (I) polymeric (III) and 2 mol Me2SiCl are formed.
ChemInform Abstract: Structures of Polynuclear Hydrolysis Complexes of Indium(III) in Aqueous Solution.
Authors: CAMINITI R. , JOHANSSON G. , TOTH I. 
Published: May 2016

AbstractLarge angle X‐ray diffraction results for hydrolyzed In(III) nitrate solutions indicate the presence of polynuclear hydrolysis complexes with single hydroxo bridges between the In atoms.
ChemInform Abstract: Kinetics and Mechanisms of the Reactions of Ketenes with Water and Alcohols in Dioxane Solutions.
Authors: POON N. L. , SATCHELL D. P. N. 
Published: May 2016

AbstractThe spontaneous addition of water to diphenyl‐ and to dimethyl‐ketene in dioxane‐H2O and dioxane‐D2O mixtures is third order in the stoichiometric water concentration, (H2O)s, when (H2O)s ≤ 1.5 M. At higher water concentrations (up to 19 M) the observed order falls, and the patterns of the results for the two ketenes are similar, but differ in detail.
ChemInform Abstract: The Selective Dealkylation of Mixed Esters of Phosphoric Acid and Phenylphosphonic Acid Using Cation Exchange Resin.
Authors: NITTA Y. , ARAKAWA Y. 
Published: May 2016

AbstractThe mixed phosphoric acid esters (I) are selectively dealkylated with cation exchange resin (II) to yield the monoesters (III).
ChemInform Abstract: Reaction of Trivalent Phosphorus Thioesters with Complex Hydrides of Alkali Metals.
Authors: SINYASHIN O. G. , GORSHUNOV I. YU. , IVASYUK I. V. , BATYEVA E. S. , PUDOVIK A. N. 
Published: May 2016

AbstractThe ethylthio groups of the trivalent P‐esters (I) and (III) are substituted by hydrogen upon reaction with lithium aluminum hydride, thus producing the phosphines (II) and (IV).
ChemInform Abstract: Synthesis of Pyrimidin‐2‐one Nucleosides as Acid‐Stable Inhibitors of Cytidine Deaminase.
Authors: KIM C.‐H. , MARQUEZ V. E. , MAO D. T. , HAINES D. R. , MCCORMACK J. J. 
Published: May 2016

AbstractThe bromo pyrimidine (I) is debrominated and subsequently reduced to give the alcohol (IV), which is converted to the 2‐methoxy pyrimidines (V).
ChemInform Abstract: A New Route to Racemic erythro‐Sphingosine and Ceramides. The 1,2‐ versus 1,4‐Addition Reaction of Hexadec‐2‐enal with 2‐Nitroethanol.
Authors: HINO T. , NAKAKYAMA K. , TANIGUCHI M. , NAKAGAWA M. 
Published: May 2016

AbstractThe reaction of the known aldehyde (I), with the alcohol (II) yields the pyranol (III) and the methanol adduct (IV) or the 1,2‐adducts (V) and (VI), depending on the reaction conditions.
ChemInform Abstract: Synthesis of Tetraisopropylethane and Tetracyclopropylethane and Generation of the Pentacyclopropylethyl Carbocation.
Authors: BRUCH M. , JUN Y. M. , LUEDTKE A. E. , SCHNEIDER M. , TIMBERLAKE J. W. 
Published: May 2016

AbstractDicyclopropyl ketone (I) is coupled with hydrazine to produce the azine (II) which is converted to the isomeric azo derivatives (III).
ChemInform Abstract: Synthesis and Some Reactions of 1‐Oxaspiro(2,11)tetradecane.
Authors: KAC'YAN L. I. , STEPANOVA N. V. , SKIBA G. V. , LEL'GANT O. M. 
Published: May 2016

AbstractThe title compound (IV) is obtained from the olefin (III) with peracetic acid.
ChemInform Abstract: A Synthesis of Substituted Pyrrolidines via a Palladium(2+)‐Catalyzed Cyclization. An Unusual Approach to a Carbapenem.
Authors: TROST B. M. , CHEN S.‐F. 
Published: May 2016

AbstractThe reaction of the alkynes (I) according to A) yields mixtures of the pyrroles (II) and (III) in the ratios shown in the scheme.
ChemInform Abstract: Enantiospecific Synthesis of the C‐9 to C‐18 Fragment of Macbecins I and II.
Authors: BAKER R. , CUMMINGS W. J. , HAYES J. F. , KUMAR A. 
Published: May 2016

AbstractPropargyl alcohol (III) is transformed into the volatile and unstable aldehyde (IV) which is converted to the unsaturated lactone (VII) via the erythroisomer (VI).
ChemInform Abstract: Synthesis, Stereochemical Analysis, and Ligand‐Transformation Reactions of New Classes of Bicapped Tricobalt Clusters, (Co3(η5‐C5H5‐xMex)3(μ3‐X)(μ3‐Y))n (x = 0, 1, 5), Containing Mixed π‐Acceptor X and π‐Donor Y Capping Ligands (X: CO, NO; Y: NSiMe3, NC(O)NH2, NH): A Rational Preparative Route to Nitrene (μ3‐NH) Clusters and the Unprecedented Direct Exchange of an Isoelectronic μ3‐NO+ Ligand for a μ3‐CO Ligand.
Authors: BEDARD R. L. , RAE A. D. , DAHL L. F. 
Published: May 2016

AbstractThe reactions of trimethylsilyl azide with the starting compounds (I) lead to different products depending on the degree of methyl substitution at the cyclopentadienyl ring.
ChemInform Abstract: Rearrangement of Spiro(benzocyclobutene‐1,3′‐piperidines).
Authors: VON SPRECHER G. , WINKLER T. 
Published: May 2016

AbstractTreatment of the spirobenzocyclobutene piperidines (Id) ‐ (Ig) with aluminum trichloride produces the rearranged compounds (II) as the main products and (III) and (IV) as by‐products.
ChemInform Abstract: Synthesis of 11H‐Pyridocarbazoles and Derivatives. Comparison of Their DNA Binding and Antitumor Activity with Those of 6H‐ and 7H‐Pyridocarbazoles.
Authors: LESCOT E. , MUZART G. , MARKOVITS J. , BELLENEY J. , ROQUES B. P. , LE PECQ J.‐B. 
Published: May 2016

AbstractCondensation of isoquinolylhydrazines (I) with the cyclohexanone (II) yields the tetrahydrocarbazoles (III) which undergo dehydrogenation to give (IV).
ChemInform Abstract: Transannular Bond Formation Between the Amino and the Sulfonio Groups in 6,7‐Dihydro‐6‐methyl‐5H‐dibenzo(b,g) (1,5)thiazocinium Salts. The First Example of a Sulfurane with an Apical Alkyl Group.
Authors: AKIBA K. , TAKEE K. , SHIMIZU Y. , OHKATA K. 
Published: May 2016

AbstractA series of S‐substituted thiazocinium salts (I) have been prepared (see scheme).
ChemInform Abstract: Synthesis and Characterization of Substitution‐Inert Cobalt(III) Complexes Containing an N‐Glycoside Derived from Ethylenediamine and a Monosaccharide (D‐Mannose, L‐Rhamnose, or D‐Ribose).
Authors: ISHIDA K. , YANO S. , YOSHIKAWA S. 
Published: May 2016

AbstractThe 1:2:2 molar reactions of Co(II) chloride hexahydrate with a corresponding monosaccharide and ethylenediamine in refluxing methanol followed by cation‐exchange column chromatography lead to the isolated complexes (I), (II), and (III).
ChemInform Abstract: Carbon‐Hydrogen Bond Activation Through a Binuclear C‐H Bond Complex.
Authors: PARK J. W. , MACKENZIE P. B. , SCHAEFER W. P. , GRUBBS R. H. 
Published: May 2016

AbstractOn treatment with two equiv. MeLi, the binuclear μ‐chloride complex (II), prepared as shown, affords the methylene‐ and methyl‐bridged product (III) in 90% yield as determined by 1H NMR (only 10% can be isolated).
ChemInform Abstract: Synthesis of Aspartyl‐Containing Peptides without Protection of the β‐Carbonyl Group.
Authors: VASIL'EVA G. A. , BAIRAMOV V. M. , EVSTIGNEEVA R. P. 
Published: May 2016

AbstractStarting with Boc‐L‐aspartic acid (I), the peptide (II) is synthesized using the pivaloyl chloride method.