bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal
Authors: Zhao Liang , Quinn Alexander , Ng Ee Ting , Veyrunes Frederic , Koopman Peter 
Published: February 2017

AbstractIn most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome (X*), yielding X*Y females. We hypothesized that X*Y sex reversal may be underpinned not only by neomorphic X chromosome functionality, but also by a compromised Sry pathway. Here, we show that neither M. minutoides SRY nor its target, the Sox9-TESCO enhancer, had appreciable transcriptional activity in in vitro assays, correlating with sequence degradation compared to Mus musculus counterparts. However, M. minutoides SRY activated its cognate TESCO to a moderate degree, and can clearly engage the male pathway in M. minutoides in the wild, indicating that SRY and TESCO may have co-evolved in M. minutoides to retain function above a threshold level. We suggest that weakening of the SRY/TESCO nexus may have facilitated the rise and spread of a variant X* chromosome carrying female-inducing modifier gene(s).
Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine
Authors: Hu Zhidong , Zhu Lingyan , Wang Jing , Wan Yanmin , Yuan Songhua , Chen Jian , Ding Xiangqing , Qiu Chenli , Zhang Xiaoyan , Qiu Chao , Xu Jianqing 
Published: February 2017

AbstractFunctional avidity of T cells is a critical determinant for clearing viral infection and eliminating tumor. Understanding how functional avidity is maintained in T cells is imperative for immunotherapy. However, studies systematically characterize T cell with high functional avidity induced in vivo are still lacking. Previously, we and others found vaccinia vectored vaccine (VACV) induced antigen-specific CD8+ T cells with relatively high functional avidity to those from DNA vaccine. Herein, we used functional, immune phenotyping and transcriptomic studies to define the immune signature of these CD8+ T cells with high functional avidity. Antigen-specific CD8+ T cells induced by VACV executed superior in vivo killing activity and displayed a distinct transcriptional profile, whereas no significantly differences were found in composition of memory sub-populations and cytokine poly-functionality. Transcriptional analyses revealed unique features of VACV induced CD8+ T cells in several biological processes, including transport, cell cycle, cell communication and metabolic processes. In summary, we characterize CD8+ T cells of high functional avidity induced in vivo by VACV, which not only improves our understanding of adaptive T cell immunity in VACV vaccination, but also provides clues to modulate functional avidity of CD8+ T cells for T cell based immunotherapy.
Controlling thermal emission of phonon by magnetic metasurfaces
Authors: Zhang X. , Liu H. , Zhang Z. G. , Wang Q. , Zhu S. N. 
Published: February 2017

AbstractOur experiment shows that the thermal emission of phonon can be controlled by magnetic resonance (MR) mode in a metasurface (MTS). Through changing the structural parameter of metasurface, the MR wavelength can be tuned to the phonon resonance wavelength. This introduces a strong coupling between phonon and MR, which results in an anticrossing phonon-plasmons mode. In the process, we can manipulate the polarization and angular radiation of thermal emission of phonon. Such metasurface provides a new kind of thermal emission structures for various thermal management applications.
Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction
Authors: Liu Huihui , Li Wan , He Qing , Xue Jinjuan , Wang Jiyun , Xiong Caiqiao , Pu Xiaoping , Nie Zongxiu 
Published: February 2017

AbstractChronic kidney disease (CKD) poses a serious threat to the quality of human life and health with an increasing incidence worldwide. Renal fibrosis is closely related to CKD and regarded as the final common pathophysiological pathway in most cases of end-stage renal diseases. Elucidating the mechanisms underlying renal fibrosis and developing novel therapeutic strategies are of great importance. Herein, matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) based on 1, 5-diaminonaphthalene hydrochloride was applied to the rat model of unilateral ureteral obstruction (UUO) to investigate metabolic changes during renal fibrosis. Among identified endogenous compounds, twenty-one metabolites involved in metabolic networks such as glycolysis, tricarboxylic acid (TCA) cycle, ATP metabolism, fatty acids metabolism, antioxidants, and metal ions underwent relatively obvious changes after 1 and 3 weeks of UUO. Unique distribution of the metabolites was obtained, and metabolic changes of kidneys during renal fibrosis were investigated simultaneously for the first time. These findings once again highlighted the promising potential of the organic salt matrix for application in small molecule in situ MSI and in the field of biomedical research.
Effects of fish density distribution and effort distribution on catchability
Authors: Ellis Nick , Wang You-Gan 
Published: February 2017

Abstract
Ellis, N., and Wang, Y-G. 2007. Effects of fish density distribution and effort distribution on catchability – ICES Journal of Marine Science, 64, 178–191. The effects of fish density distribution and effort distribution on the overall catchability coefficient are examined. Emphasis is also on how aggregation and effort distribution interact to affect overall catch rate [catch per unit effort (cpue)]. In particular, it is proposed to evaluate three indices, the catchability index, the knowledge parameter, and the aggregation index, to describe the effectiveness of targeting and the effects on overall catchability in the stock area. Analytical expressions are provided so that these indices can easily be calculated. The average of the cpue calculated from small units where fishing is random is a better index for measuring the stock abundance. The overall cpue, the ratio of lumped catch and effort, together with the average cpue, can be used to assess the effectiveness of targeting. The proposed methods are applied to the commercial catch and effort data from the Australian northern prawn fishery. The indices are obtained assuming a power law for the effort distribution as an approximation of targeting during the fishing operation. Targeting increased catchability in some areas by 10%, which may have important implications on management advice.
Gas-phase formation of the prebiotic molecule formamide: insights from new quantum computations
Authors: Barone V. , Latouche C. , Skouteris D. , Vazart F. , Balucani N. , Ceccarelli C. , Lefloch B. 
Published: February 2017

Abstract
New insights into the formation of interstellar formamide, a species of great relevance in prebiotic chemistry, are provided by electronic structure and kinetic calculations for the reaction NH2 + H2CO → NH2CHO + H. Contrarily to what previously suggested, this reaction is essentially barrierless and can, therefore, occur under the low temperature conditions of intestellar objects thus providing a facile formation route of formamide. The rate coefficient parameters for the reaction channel leading to NH2CHO + H have been calculated to be A = 2.6 × 10−12 cm3 s−1, β = −2.1 and γ = 26.9 K in the range of temperatures 10–300 K. Including these new kinetic data in a refined astrochemical model, we show that the proposed mechanism can well reproduce the abundances of formamide observed in two very different interstellar objects: the cold envelope of the Sun-like protostar IRAS16293−2422 and the molecular shock L1157-B2. Therefore, the major conclusion of this Letter is that there is no need to invoke grain-surface chemistry to explain the presence of formamide provided that its precursors, NH2 and H2CO, are available in the gas phase.
Clinical Outcomes Following Surgical Management of Coexisting Parkinson Disease and Cervical Spondylotic Myelopathy
Authors: Xiao Roy , Miller Jacob A. , Lubelski Daniel , Mroz Thomas E. , Benzel Edward C. , Krishnaney Ajit A. , Machado Andre 
Published: February 2017

Abstract

BACKGROUND: Distinguishing the causes of weakness and gait instability in patients with Parkinson disease (PD) and cervical spondylotic myelopathy (CSM) is a diagnostic and therapeutic challenge due to symptomatic similarities. No study has reported outcomes following decompression in patients with PD and CSM.

OBJECTIVE: To report outcomes following cervical decompression for patients with coexisting PD and CSM.

METHODS: A retrospective matched cohort study of all patients with PD and CSM undergoing cervical decompression at a tertiary-care center between January 1996 and December 2014 was conducted. PD patients were matched to patients with CSM alone by age, gender, American Society of Anesthesiologists classification, and operative parameters. Myelopathy was assessed by Nurick and modified Japanese Orthopaedic Association (mJOA) scales. The effect of PD on mJOA was modeled using multivariable regression.

RESULTS: Twenty-one matched pairs were included. PD patients experienced poorer improvement in Nurick (0.0 vs –1.0, P < .01) and mJOA (0.9 vs 2.5, P < .01) composite scores. However, no significant changes in absolute improvement in the upper extremity motor, upper extremity sensory, or sphincter mJOA components were observed. Multivariable regression identified PD as a significant predictor of decreased improvement in mJOA (β = –0.89, P < .01) and failure to achieve a minimal clinically important difference in change in mJOA (OR 0.18, P = .03).

CONCLUSION: This study is the first to characterize outcomes following cervical decompression in patients with PD and CSM. PD patients experienced symptomatic improvement but less overall improvement in myelopathy compared to controls. However, PD patients demonstrated improvement in upper extremity motor, upper extremity sensory, and sphincter symptoms no worse than control patients.
ACCULTURATION AND CORONARY HEART DISEASE IN JAPANESE-AMERICANS
Authors: MARMOT MICHAEL G. , SYME S. LEONARD 
Published: February 2017

Abstract
Among men of Japanese ancestry, there is a gradient in the occurrence of coronary heart disease (CHD). It is lowest in Japan, intermediate in Hawaii, and highest in California. This gradient appears not to be completely explained by differences in dietary intake, serum cholesterol, blood pressure or smoking. To test the hypothesis that social and cultural differences may account for the CHD differences between Japan and the United States, 3809 Japanese-Americans in California were classified according to the degree to which they retained a traditional Japanese culture. The most traditional group of Japanese-Americans had a CHD prevalence as low as that observed in Japan. The group that was most acculturated to Western culture had a three- to five-fold excess in CHD prevalence. This difference in CHD rate between most and least acculturated groups could not be accounted for by differences in the major coronary risk factors.
A STUDY OF HEPATITIS B ANTIGEN CARRIERS AMONG SCHOOL CHILDREN IN NETANYA, ISRAEL
Authors: NAGGAN L. , MORAG B. , BAR-SHANY S. , BRACHOTT D. 
Published: February 2017

Abstract
In the town of Netanya 9162 elementary school children (age 6–14 years)were tested for hepatitis B antigen (HBsAg) by the counter-electrophoresis method. The overall prevalence was 1.8% with a higher rate for males (2.2%)than for females (1.4%). Higher rates were observed among children born in the autumn and winter, particularly among the boys. This seasonal trend and male-female difference may partially be explained if infection occurs at circumcision. The ethnic distribution showed highest rates among children of Libyan and Yemenite origin (3.9% and 2.6%. respectively), and lowest rates among children of European and Israeli born parents (0.4% and 0.2%, respectively). Prevalence of HBsAg among children from large families andthose from families living in poor and crowded quarters was very significantly higher than among children from smaller families living in richer areas and inless crowded conditions. These variables, which are closely associated with social class, remain significant after adjustment for ethnic origin and seem toaccount for a large proportion of the variation among the Israeli school children. The variation due to ethnicity is markedly reduced when adjusted for five other pertinent variables: age, sex, season of birth, crowding and family size. Assuming that prevalence of HBsAg in a population reflects the rates of infection (past or present), the results of this study strongly support the hypothesis that type B hepatitis in Israel behaves essentially as a contagious infection manifested primarily as a subclinical disease of early and mid-child-hood.
CONTROLLING FOR TIME-VARYING POPULATION DISTRIBUTIONS IN DISEASE CLUSTERING STUDIES
Authors: ROBERSON PAUL K. 
Published: February 2017

Abstract
Both the Knox test and the Mantel test for the presence of disease clustering have previously been shown to be sensitive to changes that occur in the relative geographic population distribution during the time period of study. Although these procedures do not require knowledge of the underlying population density, they implicitly assume it is constant with time. If this is not the case, one may detect clustering which is completely independent of the disease process and simply reflects time-space clustering of the population. Modified procedures are presented which incorporate information from appropriately selected controls to adjust for the effect of a shifting population. Results of a computer simulation study demonstrating the stability of the modified tests in the face of an expanding population are reported.
APPROPRIATE PUBLIC HEALTH RESPONSES TO CLUSTERS: THE ART OF BEING RESPONSIBLY RESPONSIVE
Authors: BENDER ALAN P. , WILLIAMS ALLAN N. , JOHNSON REBECCA A. , JAGGER HELEN G. 
Published: February 2017

Abstract
Between 1981 and 1988, the Minnesota Department of Health actively responded to over 400 reports from persons concerned about disease occurrence in their community, school, or workplace. Almost all of these reports involved perceived excesses of cases of cancer. Although there is little potential for identifying unsuspected public health problems or developing new etiologic insights, the Minnesota Department of Health has found that responding to reported clusters is a legitimate and necessary public health activity. To be responsibly responsive to these concerns, the Department has developed four steps to prioritize investigation of reported disease clusters, as well as six criteria for determination of the feasibility of environmental epidemiologic investigations. Approximately 95% of all concerns have been handled within the first two steps of this approach, generally requiring only education, or sometimes examination of readily-available data. Less than 5% of the concerns have required additional data collection and evaluation, and only about 1% have resulted in full-scale epidemiologic studies. Successful conclusions at all levels of this process require that public health officials develop effective communication, maintain objectivity, and provide leadership for controversial and difficult issues.
Main causes that lead strategies to decline at execution phase: an analysis of Brazilian companies
Authors: Bernardo Samuel Moretti , Anholon Rosley , Novaski Olivio , Silva Dirceu , Quelhas Osvaldo Luiz Gonçalves 
Published: February 2017

Purpose
The purpose of this paper is to identify what are the main causes that lead strategies to decline at execution phase.

Design/methodology/approach
The paper adopted the strategy of survey with the 69 Brazilian businessmen. The questionnaire was developed from 16 causes pointed out in the literature and the results analyzed using Cronbach’s α coefficient, multidimensional scaling, exploratory factor analysis and Pearson correlation coefficient.

Findings
The results of statistical analysis showed that the main causes are primarily associated to leaders’ defaults during execution strategies, lack of support and feedback of senior management, no involvement of the teams during the strategies formulation, failure of communication on the strategic objectives in all organizational levels, and others.

Research limitations/implications
The 69 businessmen work in different sectors and there may be specific causes for each sector. The research presented by this paper did not have objectives to analyze specific sectors of the economy.

Practical implications
The results are extremely important and useful for managers during the implementation phase of the strategies and researchers in the field of business strategies.

Originality/value
There are no research with the same focus and objective presented by this paper about Brazilian companies.
Technical efficiency in dairy farms
Authors: Mareth Taciana , Thomé Antônio Márcio Tavares , Scavarda Luiz Felipe , Cyrino Oliveira Fernando Luiz 
Published: February 2017

PurposeThis systematic literature review integrates the findings of existing studies regarding technical efficiency (TE) in dairy farms. The purpose of this paper is to offer a research framework that assembles TE descriptors, a classification of previous literature that provides the basis for the synthesis and research agenda.Design/methodology/approachThis paper systematically reviews 86 survey research studies using rigorous and reproducible procedures. The review is applied to published survey research.FindingsThe framework relates context, inputs, outputs and metrics of TE. There is no agreement among the authors on the context and determinants of TE. The main determinants of TE are geographical location, farm size, investments in veterinary care, feeding and milking practice, TE model estimation techniques, public policy, and management-related variables. This paper offers ten propositions for future research on the controversial results on the determinants of TE. The authors also explore the reasons for the discrepant results based on the Debreu-Farrell’s definition of TE, the contingency theory and the resource-based view of the firm, elucidating the literature and serving as a basis for future investigation. Implications for dairy farmers and researchers close the review.Originality/valueMeta-analysis and meta-regression studies were long at the forefront of reviews in the TE of dairy farms. This paper offers a novel qualitative research synthesis with frameworks and the classification of previous literature and a research agenda, which provides a new and different perspective for analysis, by innovating over the available quantitative procedures to combine statistical results.
Style and substance: a case study of the expansion of mature business-to-business relationships in the Italian clothing industry
Authors: Colucci Mariachiara , Visentin Marco 
Published: February 2017

Purpose
This paper aims to propose a model of the determinants of the expansion of mature business-to-business relationships in the downstream channel of the Italian clothing industry. The authors investigate the role of both economic and social determinants of retail buyers’ intentions to expand their relationships with a seller.

Design/methodology/approach
The empirical analysis is based on surveys of more than 150 retail buyers in mature relationships with a major clothing company. This context offers a unique opportunity to explore the interplay between the need for stable relationships and the need to continuously innovate to satisfy consumer demand, given rapidly changing tastes and styles, which can inhibit relationship expansion.

Findings
Buyers’ intentions to expand relationships are primarily determined by the absence of a formal agreement with the seller. Perceptions of a seller’s goodwill seem to overshadow the detrimental effects of two likely sources of opportunism in the clothing industry: demand uncertainty and the availability of alternative suppliers. Findings also provide evidence of a substitutive effect of formal control and trust in mature business relationships.

Originality/value
The authors provide insights into the dynamics of mature business relationships with a focus on expansion, rather than just the propensity for relational continuity, and they show how the interplay of transaction costs and social dimensions leads to this expansion. The authors also provide empirical evidence of a context, the clothing industry, where downstream relationships represent an important source of competitive advantage.
Thirty years of the Journal of Business & Industrial Marketing: a bibliometric analysis
Authors: Valenzuela Leslier Maureen , Merigó José M. , Johnston Wesley J. , Nicolas Carolina , Jaramillo Jorge Fernando 
Published: February 2017

Purpose
The aim of this study is to reveal the contribution that Journal of Business & Industrial Marketing has to scientific research and its most influential thematic work in B-to-B since its beginning in 1986 until 2015, in commemoration of the 30th anniversary.

Design/methodology/approach
The paper begins with a qualitative introduction: the emergence of the magazine, its origins, editorial and positioning. Subsequently, it is based on bibliometric methodologies to develop quantitative analysis. The distribution of annual publications is analyzed, the most cited papers, the keywords that are mostly used, the influence on the publishing industry and authors, universities and the countries that have the most publications.

Findings
The predominant role of the USA at all levels is highlighted. It also highlights the presence (given its size and population) of the countries of Northern Europe. There is great interest in appreciating the evolution of the number of publications that are always increasing which demonstrates the growing and sustained interest in these types of articles, with certain times of retreat (often coincide with economic crisis).

Research limitations/implications
The Scopus database gives one unit to each author, university or country involved in the paper, without distinguishing whether it was one or more authors in the study. Therefore, this may bring some deviations in the analysis. However, the study considers some figures with fractional counting to partially solve these limitations.

Practical implications
After observing the different perspectives of the journal’s production, it allows to give an objective view of the evolution that the Journal of Business & Industrial Marketing has had in the past 30 years.

Originality/value
It is part of the trend that several journals (Journal of Marketing, Journal of Public Policy & Marketing, Journal of Marketing Research, Journal of Business Research) made special sections to show progress and contribution of these journals to scientific research.