bluuebunny/crossref_metadata_2025_split huggingface dataset:
La deshumanización médica y social ante la pérdida embriofetal en madres gestantes
Authors: García Sánchez Emilio , Vila Caballer Marian 
Published: October 2024

Propósito/Contexto. En este artículo queremos evidenciar la existencia de la invisibilización médica y social producida en torno a las pérdidas embriofetales en madres gestantes.
Metodología/Enfoque. Se hace una revisión bibliográfica de carácter narrativo y bioético de publicaciones que analizan específicamente cómo afecta a las madres gestantes el modo de comunicar del personal de salud cuando han de notificar la pérdida de su hijo por complicaciones en el desarrollo embriofetal. Revisamos si en esa comunicación se aplican los principios de la Bioética.
Resultados/Hallazgos. Tras el análisis realizado encontramos que, con frecuencia, las madres gestantes que sufren esos abortos naturales, a menudo, experimentan una ausencia de empatía y humanidad en los profesionales de la salud que no cubren adecuadamente –éticamente– la magnitud que supone esa pérdida del hijo en desarrollo. Añadimos que esta situación se agrava por el sentimiento de fracaso y soledad, unido a la tristeza y el duelo por el que transitan.
Discusión/Conclusiones/Contribuciones. Realzamos el valor ontológico y humano que le otorgan las madres a la muerte del que consideran su hijo, independientemente del momento del desarrollo en el que se encuentre. La muerte imprevista en las primeras semanas del embarazo no debería quedar reducida a un accidente meramente fisiológico y sin importancia a nivel comunicativo. Concluimos que es necesario asesorar a los profesionales de salud a través de protocolos médicos y éticos que les permitan abordar el cuidado de aquellos pacientes que atraviesan esta situación de perdida embriofetal. Consideramos desde la bioética que, ante estas críticas circunstancias, debería priorizarse el principio de beneficencia, habida cuenta de que una mala comunicación afecta negativamente al bienestar físico y psíquico de estas pacientes.
The association among cancer-antigen-125 and pre-eclampsia and estimated fetal weight: A case-control study
Authors: Gholami Hamideh , Garrosi Lida , Tofighi Shabnam , Ghadimi Zahra 
Published: October 2024

Background: Although an optimal screening model is still under investigation, pre-eclampsia is a leading cause of perinatal morbidity. The association between cancer-antigen-125 (CA-125) and pre-eclampsia has been discussed in several studies recently.
Objective: We aimed to determine the association between CA-125 and preeclampsia and estimated fetal weight.
Materials and Methods: This case-control study was performed on 30 pregnant women with pre-eclampsia who were homogenized in terms of age, body mass index, and gestational age with 30 normal pregnant women. Participants were recruited via convenience sampling. The level of CA-125 in blood at the time of termination of pregnancy was measured by Enzyme Linked Immunosorbent Assay. The urine sample was used to check proteinuria. Blood pressure and pregnancy outcomes were assessed and recorded.
Results: The mean serum CA-125 level in study group was considerably higher than control group (p < 0.001). Elevating the level of CA-125 has increased the likelihood of pre-eclampsia by 1.5 times. A significant direct correlation was obtained between CA-125 level and the amount of urinary protein (r = 0.605, p < 0.001). Also, a significant but negative correlation was obtained between the CA-125 level and the estimated weight of the fetus (r = -0.593, p < 0.001).
Conclusion: Increasing the serum level of CA-125 with high sensitivity and specificity is significantly associated with the occurrence of pre-eclampsia and estimated fetal weight.
Key words: CA-125, Pre-eclampsia, Birth weight.
Evaluación De Protocolos IATF Con Semen Congelado Vs Refrigerado En Bovinos Brahman
Authors: Porras Vargas Jose Luis , Maldonado Castro Gerardo Antonio , RODRIGUEZ MOLANO CARLOS EDUARDO 
Published: October 2024

La presente investigación comparo los porcentajes de preñez al usar un semen congelado y semen refrigerado en un programa de monta estacional con inseminación artificial a término fijo (IATF) en ganado Brahman. Se extrajo semen de un toro raza Brahman con fertilidad confirmada, calidad seminal y examen reproductivo completo. Se seleccionaron 140 vacas raza Brahman y se dividieron en dos grupos cada uno de 70 vacas así: el grupo 1 se insemino con semen congelado y en el grupo 2 se insemino con semen refrigerado. El semen congelado se colecto por electroeyaculado, evaluando su calidad y conservándolo en nitrógeno líquido por 3 meses hasta su uso en el programa de IATF. El semen refrigerado, se colectó el día del programa del IATF, evaluando su calidad seminal, diluyéndolo y refrigerándolo hasta su uso en el IATF. El diagnóstico de la preñez se hizo 45 días post servicio por medio de palpación rectal y ultrasonografía, obteniendo un porcentaje de preñez del 41,42% con el semen congelado y del 60% con semen refrigerado. Se concluye que el semen refrigerado presento mejor calidad y logro la mayor tasa de preñez.
Constructing the historical memory of the 1917 revolution in school textbooks of the Republic of Azerbaijan (2018-2023)
Authors: Veremeychik M. 
Published: October 2024

The paper deals with the main conceptual approaches to the presentation of the events of the February and October stages of the 1917 Revolution in the school textbooks of the Republic of Azerbaijan. Considerable attention is paid to the national component of the 1917 Revolution – the formation of the First Republic (Azerbaijan Democratic Republic) and the Second Republic (Azerbaijan SSR). The content of textbooks on academic subjects “History of Azerbaijan” for grades 5, 9, 11 and “General History” for grades 9, 11 published in 2018 - 2023 was analyzed.
Avaliação de inteligibilidade em salas de aula com aurilizações simuladas
Authors: Mahl Ana Luiza , Tenenbaum Roberto Aizik , Melo Viviane Suzey Gomes de 
Published: October 2024

O artigo aborda uma nova técnica para avaliar a inteligibilidade da fala em salas de aula a partir de aurilizações simuladas. O objetivo principal é realizar testes de articulação a partir de sinais simulados e confrontar os resultados com testes de articulação medidos na sala real. Para tal, são escolhidas duas salas de aula em ambiente universitário. Essas salas são acusticamente medidas, de modo a determinar os tempos de reverberação (TRs) para distintas posições de receptor. As salas são, então, simuladas computacionalmente e os TRs calculados nos mesmos pontos. Um procedimento de otimização é aplicado de modo a aproximar os TRs simulados aos medidos, ajustando-se os coeficientes de absorção e espalhamento das superfícies que compõem o ambiente. Simulam-se, em seguida, as respostas impulsivas biauriculares para as mesmas posições de receptores e o resultado é convoluído com sinais anecoicos contendo listas de monossílabos, gerando aurilizações. Finalmente, as aurilizações são aplicadas por meio de fones de ouvido a um grupo de voluntários que também participaram dos testes de articulação reais e os resultados são comparados. Na comparação, verifica-se que os dois testes – reais e virtuais – apresentam diferenças da ordem de 2%, sendo a maior discrepância encontrada de 3%. Resta demonstrado, portanto, que a técnica utilizada se mostra confiável, particularmente após a aplicação do método de otimização. A utilização da técnica de avaliar inteligibilidade da fala por meio de aurilizações simuladas permite, por exemplo, ser aplicada em situações de pandemia ou demais casos em que se mostre inviável reunir um significativo número de pessoas em uma sala de aula.
Exploring grapevine canopy management: effects of removing main leaves or lateral shoots before flowering
Authors: Verdenal Thibaut , Zufferey Vivian , Dienes-Nagy Ágnès , Bieri Stefan , Bourdin Gilles , Reynard Jean-Sébastien , Spring Jean-Laurent 
Published: October 2024

Over the course of a six-year trial, we investigated the physiological response of the Swiss white cultivar Vitis vinifera Petite Arvine, rich in varietal thiols, to the following canopy removal treatments from the cluster area, i.e. from the shoot base to the sixth leaf of each shoot: A) lateral shoots only, B) lateral shoots + 50 % main leaves, C) lateral shoots + 100 % main leaves or D) main leaves only. All leaf removal (LR) treatments were performed at the pre-flowering stage.Intensive pre-flowering removal of both lateral shoots + 100 % main leaves from the cluster area (C) strongly reduced yield potential (‒47 % on average) and tended to reduce the concentration of 3-mercaptohexanol precursors (Cys-3MH) in the must (‒21 %; p-value < 0.10). The effect of LR on berry set and must composition was modulated by removing fewer main leaves (‒24 % in yield potential and ‒6 % in Cys-3MH concentration). Climate conditions primarily influenced yield and grape composition.Main leaves and lateral shoots played different physiological roles: removal of main leaves only (D) resulted in a larger leaf area (+15 %) due to the development of lateral shoots in the cluster area and a lower yield potential (‒12 %) due to fewer berries per cluster when compared one-to-one with removal of lateral shoots only (A). In the must at harvest, treatment D had higher concentrations of malic acid (+12 %), yeast-assimilable nitrogen (+10 %) and glutathione (+8 %), but there were no significant trends for TSS, pH, Cys-3MH or Folin index. The overall effects of pre-flowering LR on wine composition were negligible in the context of this trial.The study highlighted the different physiological roles of the main leaves and lateral shoots, suggesting that pre-flowering leaf removal should be used cautiously, taking into account the plant’s resilience to environmental conditions. This research is part of a broader project on grapevine canopy management in temperate climates in Switzerland.
Development of a digitalised complex intervention to promote activity of older people in rural areas: study protocol of a feasibility and pilot study
Authors: Beutner Katrin , Lamprecht Juliane , Roggendorf Sigrid , Aßmann Paula , Hübner Gundula , Steckelberg Anke , Schmidt Heike 
Published: October 2024

Abstract

Background
Age-related mobility limitations are associated with reduced activity and loss of participation, which can result in loneliness and depression. Physical activity programmes can help maintain the functional status and quality of life of older individuals, but they are rarely available and often difficult to reach, especially in rural areas. Digital assisted programmes have the potential, independent of place and time, to activate and promote physical function and social participation in older people. Therefore, this study aims (1) to develop a complex intervention comprising digital elements to promote physical activity, quality of life and participation in older people with impending or existing functional limitations and (2) to test the feasibility, acceptability and potential benefits of the developed intervention.
Methods
The development and piloting of the intervention follows the UK Medical Research Council framework for complex interventions. The intervention will be developed through participatory, co-creative processes that integrate the perspectives of all potentially relevant user groups, including older people, physiotherapists, general practitioners, and day care facilities in the participating regions. The developed intervention will be piloted using a consecutive control intervention group design with 60 older people (aged ≥ 65 years) in rural areas of Saxony-Anhalt who have existing or imminent mobility restrictions and have a medical prescription for physiotherapy. The primary feasibility outcomes will be recruitment rate, completion rate, acceptability and compliance with the study procedures and the intervention assessed by protocols, data analysis and interviews at 20-weeks follow-up. This will include evaluating adherence, utilization data, as well as identifying barriers and facilitators, using a mixed-methods design. The secondary patient-related outcomes will be physical function, physical activity, self-care, quality of life and participation measured at baseline and after 12 weeks.
Discussion
The study aims to evaluate the feasibility of a new intervention designed to promote physical activity and participation among older people living in rural areas. The pilot study will serve as a basis for an individual randomized trial to test the intervention's effectiveness. The results will inform the adaptation of the intervention to a prescribable healthcare approach.
Trial registration
DRKS, DRKS00031574. Registered on 5 May 2023, https//drks.de/search/de/trial/DRKS00031574
Selective inguinofemoral node dissection for stage III vulvar squamous cancer: feasibility and safety
Authors: Huang Yan , Wu Yong , Zhang Wei , Wu Xiaohua 
Published: October 2024

Abstract

Purpose
To assess the feasibility and outcomes of selective inguinal lymph node dissection (ILND) in stage III vulvar squamous cancer.
Methods
This study was approved by the Committee of Fudan University Shanghai Cancer Center. Ninety-one patients with stage III vulvar squamous cancer between 3/2018 and 3/2021 were included in this study. Thirty-one patients chose radical excision with selective ILND while 60 patients received radical excision with complete ILND voluntarily. After surgery, all the patients received postoperative external beam radiotherapy (EBRT). All the patients were invited to fill out two questionnaires: the EORTC QLQ-C30 and a vulvar specific questionnaire.
Results
The median follow-up time was 34 (16–50) months. There was no statistical difference in recurrence (p>0.05) or overall survival (p>0.05) in the two groups. Moreover, no difference in overall quality of life was observed between the two groups. The major difference was the increase in complaints of edema and body image after complete ILND.
Conclusions
Patients who underwent selective ILND reported less treatment related morbidity without affecting survival and overall quality of life compared to those who underwent complete ILND. Selective ILND may be a reasonable alternative for stage III vulvar squamous cancer in the future.
Efficient Transmission in Directional Cyber Networks through Vulnerability Evaluation using Deep Learning
Authors: Kumar Parasuraman , Anbarasan Anbarasa Kumar , Chinnappan Chandru Vignesh , J. Alfred Daniel , Shah Mohd Asif , Mallik Saurav 
Published: October 2024

Abstract

With the rise of cyber-physical power systems and the increasing threat of cyber-attacks, traditional power services face higher risks of compromise due to vulnerabilities in cyber communications that can lead to material damage. Therefore, adjustments need to be made to the current control scheme planning methods to mitigate the impact of potential attacks on service quality. This paper focuses on the service of synchronized source-load contribution in primary frequency regulation. A vulnerability study is conducted by modelling the attack intrusion process, and a risk assessment of the service is performed by further modelling the attack impacts on the service's physical components. Based on this, the traditional synchronized reserve allocation optimization model is adapted, and the allocation scheme is adjusted according to the impact of cyber-attacks. The proposed modification methods are validated by demonstrating their effectiveness in defending against cyber-attack impacts.
Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming
Authors: Zhao Wenxue , Yuan Weihong , Dong Tian , Qi Wei , Feng Zhijie , Li Cheng , Sun Yujie 
Published: October 2024

Abstract

Matrix stiffness can have significant effects on cell behavior, regulating processes such as proliferation, differentiation, migration, and extracellular matrix production; however, less is known regarding the epigenomic and transcriptional regulation underling the effect of matrix stiffness on cell phenotypic shifts. In the present study, we utilized an in vitro system to assess the phenotypic shifts of hepatic stellate cells (HSCs) following changes in matrix stiffness, in addition to integrating multi-omics with imaging and biochemical assays to investigate the mechanism underlying the effect of mechanical stimuli on fibrosis. We show that cells cultured on a stiff matrix display more accessible chromatin sites, which consist of primed chromatin regions that become more accessible prior to the upregulation of nearby genes. These regions are enriched in fibrosis-associated genes that function in cytoskeletal organization and response to mechanical stimuli. Mechanistically, we demonstrate that activation of the AP-1 transcription factor family is responsible for chromatin priming, among which activated p-JUN is critical for the promotion of fibrogenic phenotypic shifts. The identified chromatin accessibility-dependent effect of matrix stiffness on cellular phenotypic shifts may be responsible for various fibrotic diseases and provide insight into intervening approaches.
Effects of starvation and subsequent re-feeding on moulting interval, growth increment and mortality in common brown shrimp (Crangon crangon)
Authors: Saathoff Merten , Temming Axel , Perger Robert 
Published: October 2024

Abstract

Specimen of the common brown shrimp, C. crangon, were deprived of food and subsequently re-fed under controlled conditions (17 ± 1.7°C, ad libitum feeding) in two sets of experimental runs (2008 and 2017), to investigate the effects of starvation with subsequent re-feeding on dry mass accumulation during intermoult period, mortality and growth. Mortality was negatively affected by starvation, and re-feeding was identified as particularly critical in animal survival, as over 90% of the observed mortality occurred after the onset of re-feeding. Starvation increased the moulting interval and decreased increments after moult, resulting in a shrinkage of up to 8% within 21 days. A correlation between weight loss during starvation and decrease in length was found. The comparison of dry weight conditions of starving animals and field samples suggested that shrinkage must be a more widespread phenomenon in C. crangon than previously assumed. Based on the observations, shrinkage could be identified as a physiological necessity after starvation. Accordingly, it could also occur in other crustacean species, in the cases where an individual’s dry mass is reduced due to starvation.
Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with first-treated obsessive-compulsive disorder
Authors: Ding Yanru , Lu Shihao , Wang Shaoxia , Wang Yanrong , Wu Chujun , Du Yunyun , Fang Jianqun 
Published: October 2024

Abstract

Background
The study aimed to investigate the correlation between HCY, vitamin B12, and folate levels and cognitive function in patients with obsessive-compulsive disorder (OCD).
Methods
Fifty patients with first-treated OCD and 50 matched healthy controls recruited during the same period were enrolled. Subjects were cognitively assessed using the Wisconsin Card Sorting test (WCST) and The MATRICS Consensus Cognitive Battery (MCCB) scales. Serum homocysteine was also measured by enzyme cycle assay, serum folate and vitamin B12 by ELISA. The Kruskal-Wallis test was then used to compare the differences in hematologic indices and cognitive functioning between the OCD and control groups, and Spearman correlation analyses were used to explore the relationship between hematologic indices and cognitive functioning. Mediating effects modeling was further introduced.
Results
Patients with first-treated OCD had extensive cognitive impairment compared with controls (P <0.05). Serum homocysteine, vitamin B12, and folate levels were significantly different compared to the control group (P < 0.05). Serum homocysteine levels were positively correlated with Yale Brown Obsessive-Compulsive Scale scores and length of time spent on the Trail Making Test, and negatively correlated with verbal learning ability and emotional management ability. Folate levels were negatively correlated with Yale Brown Obsessive-Compulsive Scale scores and length of time spent on the Trail Making Test, and positively correlated with verbal learning ability and emotional management ability. No significant correlation was found with serum vitamin B12 levels. SPSS mediation effect model analysis showed that homocysteine level partially mediated the relationship between the degree of obsessive-compulsive symptoms and verbal learning ability, with a mediation effect value of -0.43, 95% CI [-0.58~-0.28], and serum folate level partially mediated the relationship between the degree of obsessive-compulsive symptoms and the speed of information processing and verbal learning ability, with a mediation effect value of 1.78,95%CI[0.62 ~ 3.47];-0.11,95%CI[-0.21~-0.03].
Conclusions
Serum homocysteine levels are positively correlated with the degree of symptoms and cognitive dysfunction in patients with first-treated obsessive-compulsive disorder, and serum folate levels may be protective against cognitive alterations in patients with first-treated OCD. Symptom severity of OCD and serum homocysteine and folate levels together influence cognitive function.
Evaluating the Diagnostic Performance of GPT-4o in Glaucoma: A Comparative Study with Human Ophthalmologists
Authors: Zhang Junxiu , Ma Yao , Zhang Rong , Chen Yanhua , Rina Su , Ma Ke , Xu Mengyao 
Published: October 2024

Abstract

Background: Artificial intelligence, particularly large language models like GPT-4o, holds promise for enhancing diagnostic accuracy in healthcare. This study evaluates the diagnostic performance of GPT-4o compared to human ophthalmologists in glaucoma cases.
Methods: A prospective, observational study was conducted at a tertiary care ophthalmology center. Twenty-six glaucoma cases, including both primary and secondary types, were selected from publicly available databases and institutional records. The cases were analyzed by GPT-4o and three ophthalmologists with varying levels of experience. The accuracy and completeness of primary and differential diagnoses were assessed using 10-point and 6-point Likert scales, respectively. Statistical analyses were performed using nonparametric methods, including the Kruskal-Wallis and Mann-Whitney U tests.
Results: GPT-4o was significantly less accurate in primary diagnosis compared to all ophthalmologists, particularly Doctor C, who had the highest accuracy. In terms of completeness, GPT-4o also ranked lower than the human experts. However, in differential diagnosis, GPT-4o showed comparable accuracy to Doctors A and C and excelled in completeness, outperforming two of the three ophthalmologists.
Conclusions: While GPT-4o demonstrates potential in generating comprehensive differential diagnoses, it lags behind human specialists in primary diagnosis accuracy and completeness. These findings suggest that GPT-4o could serve as a valuable adjunct in clinical practice, particularly in complex cases, but should not replace human expertise, especially for initial diagnoses. Future improvements in AI models could enhance their utility in ophthalmology and other specialized fields.