bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photodynamic inactivation of edible photosensitizers for fresh food preservation: Comprehensive mechanism of action and enhancement strategies
Authors: Li Haoran , Ni Yongsheng , Zhao Jinsong , Li Yumeng , Xu Baocai 
Published: September 2024

AbstractFoodborne harmful bacteria not only cause waste of fresh food, but also pose a major threat to human health. Among many new sterilization and preservation technologies, photodynamic inactivation (PDI) has the advantages of low‐cost, broad‐spectrum, energy‐saving, nontoxic, and high efficiency. In particular, PDI based on edible photosensitizers (PSs) has a broader application prospect due to edible, accessible, and renewable features, it also can maximize the retention of the nutritional characteristics and sensory quality of the food. Therefore, it is meaningful and necessary to review edible PSs and edible PSs‐mediated PDI, which can help to arouse interest and concern and promote the further development of edible PSs‐mediated PDI in the future field of nonthermally sterilized food preservation. Herein, the classification and modification of edible PSs, PS‐mediated in vivo and PS‐mediated in vitro mechanism of PDI, strengthening strategy to improve PDI efficiency by the structure change synergistic and multitechnical means, as well as the application in fresh food preservation were reviewed systematically. Finally, the deficiency and possible future perspectives of edible PSs‐mediated PDI were articulated. This review aimed to provide new perspective for the future food preservation and microbial control.
A phase II study of weekly carboplatin and concurrent radiotherapy in older adults with locally advanced non‐small cell lung cancer (LOGIK1902)
Authors: Harada Taishi , Sasaki Tomonari , Ishii Hidenobu , Takemoto Shinnosuke , Hisamatsu Yasushi , Saito Haruhiro , Yoneshima Yasuto , Komiya Kazutoshi , Kashiwabara Kosuke , Naoki Katsuhiko , Ogawa Tomohiro , Takeoka Hiroaki , Saruwatari Koichi , Ito Kensaku , Tsuchiya‐Kawano Yuko , Mizuno Keiko , Shimose Takayuki , Shioyama Yoshiyuki , Okamoto Isamu 
Published: September 2024

AbstractBackgroundConcurrent chemoradiotherapy is the standard therapy for locally advanced non‐small cell lung cancer (NSCLC). However, there is little evidence supporting its use in older adults. Low‐dose daily carboplatin combined with thoracic radiotherapy is considered a standard regimen for this population. To establish a simple and feasible carboplatin administration method, we conducted a study of weekly carboplatin and concurrent radiotherapy for older adults with locally advanced NSCLC.MethodsThis prospective, single‐arm, multicenter, phase II clinical trial included patients aged ≥75 years with unresectable stage III NSCLC and Eastern Cooperative Oncology Group performance status 0–1. Patients received chemoradiotherapy (60 Gy/30 fractions plus concurrent weekly carboplatin at an area under curve of 2 mg mL−1 min−1). The primary endpoint was the overall response rate (ORR). Key secondary endpoints included progression‐free survival (PFS), overall survival (OS), and safety.ResultsFrom July 2020 to June 2022, 37 patients were enrolled from 15 institutions, and 36 patients were evaluable for efficacy and safety. The ORR was 63.9% (95% confidence interval [CI] = 47.6–77.5). Median PFS was 14.6 months (95% CI = 9.1–18.1). Median OS was 25.5 months (95% CI = 17.4–not reached). Grade 4 leucopenia, neutropenia, and thrombocytopenia were observed in one patient (2.8%) each.ConclusionWeekly carboplatin and concurrent radiation therapy was safe in older adults with locally advanced NSCLC, and promising activity was observed.
Impaired or not impaired: The accuracy of the Montreal Cognitive Assessment in detecting cognitive impairment among patients with alcohol use disorder
Authors: Høiland Kristoffer , Arnevik Espen Kristian Ajo , Diep Lien My , Mathisen Tove , Witkiewitz Katie , Egeland Jens 
Published: September 2024

AbstractBackgroundCognitive impairments are common in alcohol use disorder (AUD), but only a few studies have investigated the accuracy of the Montreal Cognitive Assessment (MoCA) in this population. We examined the accuracy and precision of the MoCA in detecting cognitive impairment in a sample of patients with AUD. In addition, we investigated whether the MoCA predicts premature discontinuation from treatment.MethodA sample of 126 persons with AUD undergoing treatment in specialist health services were administered the MoCA and a battery of 12 neuropsychological tests. Five cognitive domains were derived from the reference tests. A composite total score from these tests was used as a reference criterion for determining correct and incorrect classifications for the MoCA. We analyzed the optimal cut‐off score for the MoCA and the accuracy and agreement of classification between the MoCA and the reference tests.ResultsReceiver operating characteristic (ROC) curve analyzes yielded an area under the curve (AUC) of 0.77 (95% CI [0.67, 0.87]). Applying 25 as the cut‐off, MoCA sensitivity was 0.77 and specificity 0.62. The PPV was 0.53. The NPV was 0.84. Using a cut‐off score of 24 yielded a lower sensitivity 0.60, but specificity was significantly better i.e., 0.79. PPV was 0.68. The NPV was 0.82. Kappa agreement between MoCA and the reference tests was fair to moderate, 0.38 for the cut‐off of 25, and 0.44 for the cut‐off of 24. MoCA did not predict discontinuation from treatment.ConclusionsOur findings indicate limitations in the classification accuracy of the MoCA in predicting cognitive impairment in AUD. Achieving the right balance between accurately identifying impaired cases without including too many false positives can be challenging. Further, MoCA does not predict discontinuation from treatment. Overall, the results do not support MoCA as a time‐efficient screening instrument.
Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE‐mediated food allergies
Authors: Lai C. L. , Santner‐Nanan B. , Maltese P. J. , Ong C. K. S. , Palmer D. J. , Campbell D. E. , Makrides M. , Gold M. , Nanan R. , Prescott S. L. , Hsu P. S. 
Published: September 2024

AbstractBackgroundReasons for Th2 skewing in IgE‐mediated food allergies remains unclear. Clinical observations suggest impaired T cell activation may drive Th2 responses evidenced by increased atopic manifestations in liver transplant patients on tacrolimus (a calcineurin inhibitor). We aimed to assess differentiation potential, T cell activation and calcium influx of naïve CD4+ T cells in children with IgE‐mediated food allergies.MethodsPeripheral blood mononuclear cells from infants in the Starting Time for Egg Protein (STEP) Trial were analyzed by flow cytometry to assess Th1/Th2/Treg development. Naïve CD4+ T cells from children with and without food allergies were stimulated for 7 days to assess Th1/Th2/Treg transcriptional factors and cytokines. Store operated calcium entry (SOCE) was measured in children with and without food allergies. The effect of tacrolimus on CD4+ T cell differentiation was assessed by treating stimulated naïve CD4+ T cells from healthy volunteers with tacrolimus for 7 days.ResultsEgg allergic infants had impaired development of IFNγ+ Th1 cells and FoxP3+ transitional CD4+ T cells compared with non‐allergic infants. This parallels reduced T‐bet, IFNγ and FoxP3 expression in naïve CD4+ T cells from food allergic children after in vitro culture. SOCE of naïve CD4+ T cells was impaired in food allergic children. Naïve CD4+ T cells treated with tacrolimus had reduced IFNγ, T‐bet, and FoxP3, but preserved IL‐4 expression.ConclusionsIn children with IgE‐mediated food allergies, dysregulation of T helper cell development is associated with impaired SOCE, which underlies an intrinsic impairment in Th1 and Treg differentiation. Along with tacrolimus‐induced Th2 skewing, this highlights an important role of SOCE/calcineurin pathway in T helper cell differentiation.
Can Chinese‐style trade unions promote corporate philanthropy? A stakeholder theory perspective
Authors: Cui Yadong , Xu Su , Jiang Yaohui , Zhang Zhaowen , Hu Haoyu 
Published: September 2024

AbstractCorporate philanthropy is an important form of fulfilling social responsibility and improving social income distribution systems. Unlike Western trade unions, Chinese trade unions have government‐like functions. This study discusses whether Chinese‐style trade unions help promote corporate philanthropy. Based on stakeholder theory, this study examines the philanthropic effects of Chinese‐style trade unions using data from the Chinese Private Enterprises Survey and employs methods such as the Treatment Effect Model, Instrumental Variables Method, and Propensity Score Matching. The results show that unions with government‐like functions can significantly incentivize firms to engage in philanthropic activities and that this effect encourages start‐ups and well‐funded firms, which enriches and expands the research on the functions of unions. Trade unions can help enterprises gain political connections and promote a sense of corporate social responsibility, thus enhance corporate philanthropy. In addition, female leaders are more likely than male leaders to promote the positive impact of unions on corporate philanthropy. This study not only expands the literature on union functions and the antecedents of corporate philanthropy, but also enriches the discussion on the synergies among multiple stakeholders in stakeholder theory and the role of gender in the field of management.
Cost of debt financing, stock returns, and corporate strategic ESG disclosure: Evidence from China
Authors: Wang Wenjiao , Sun Ziyuan , Dong Yuting , Zhang Longyu 
Published: September 2024

AbstractWhether corporate strategic Environmental, Social, and Governance (ESG) disclosure can be effectively screened by external markets still needs more empirical support. Despite numerous studies confirming the positive impact of ESG, the issue of strategic ESG disclosure has yet to receive sufficient attention. This study examines the impact of ESG greenwashing on the cost of debt financing and stock returns using panel data of Chinese A‐share listed corporates from 2012 to 2021. The study finds that external markets fail to recognize ESG greenwashing in the short term, leading to a temporary reduction in the cost of debt financing and an increase in stock returns, but these effects are not lasting. Mechanism analysis shows that ESG greenwashing enhances corporate reputation and reduces the cost of debt financing through the reputation effect, stimulates investor sentiment, and improves stock returns through the sentiment effect. The study identifies management myopia, excessive power, financial distress, and information asymmetry as the main drivers. However, strong oversight by independent directors, involvement of Big Four audit firms, investor site visits, and high industry competition can mitigate these misleading effects. This research expands the understanding of the causes and economic consequences of corporate ESG greenwashing and provides empirical evidence for managing this phenomenon.
Validation of the Parent Version of the Nighttime Fears Scale (NFS‐P) for Children Aged 3–8 Years
Authors: Orgilés Mireia , Galán‐Luque Teresa , Espada José Pedro , Morales Alexandra 
Published: September 2024

ABSTRACTBackgroundNighttime fears are highly prevalent in children, ranging from normative fears to triggering fear‐related anxiety disorders. The lack of available assessment instruments recently prompted the development of the Nighttime Fears Scale (NFS) for children aged 8–12 years. The present study aimed to adapt and psychometrically evaluate the parent‐reported version for children aged 3–8 years (NFS‐P) as a complement for younger children.MethodsTwo hundred eighty‐four Spanish‐speaking parents (47% girls) completed the NFS‐P and anxiety measures.ResultsConfirmatory factor analyses supported a four‐factor structure of the NFS‐P. Strong internal consistency and validity evidence were obtained. No significant differences were found in NFS‐P scores between sexes and age groups.ConclusionsThe findings offer support for the use of the NFS‐P as a valuable instrument in clinical and research settings, supplementing the NFS for older children. Both scales provide an efficient means to comprehensively assess the presence and intensity of typical nighttime fears across preschool and school years.
Immunocellular microenvironment of the vascular wall of cerebral aneurysms: What is the role of inflammatory cells in aneurysmal remodeling?
Authors: Kumar Vivig Shantha , Resheek Nerella , Kumar Vignarth Shantha , Kumar Ruthvik Thaghalli Sunil 
Published: September 2024

AbstractIntracranial aneurysms (IAs) may afflict up to 5% of the general population, or up to 15 million individuals in the US. The two forms of IAs that can be recognized by their shape are saccular and nonsaccular IAs, with uncommon aneurysm types, fusiform and dissecting aneurysms, comprising 13% of nonsaccular IAs. Conceivably, among the various risk factors for IA development, vessel wall inflammation represents a major cause. Accordingly, IAs may not necessarily be the result of passive widening of vessel wall structures, but may also be the result of inflammation and tissue degeneration. Thus, flow‐induced vascular remodeling during IA pathogenesis may reflect immune cell infiltration and consequent release of proinflammatory cytokine, chemokine, and matrix metalloproteinase that contribute to vessel wall degeneration and weakening. Thus, infiltrating neutrophils, macrophages, T‐lymphocytes and complement factors, and the resulting immune microenvironment may be pertinent in IA pathogenesis.
Challenges of regulating commercial use of marine elapid snakes in the Indo‐Pacific
Authors: Auliya Mark , Rasmussen Arne Redsted , Sanders Kate L. , Lobo Aaron Savio 
Published: September 2024

AbstractMarine elapid snakes are a diverse, predominantly Indo‐West Pacific species group. The persistent removal of some species has an unquantified but potentially dire impact on populations. We conducted the first comprehensive review of the trade in marine elapid snakes based on published literature (1974–2022) and trade data from the only species (i.e., Hydrophis [Lapemis] curtus) whose trade is monitored internationally. Some species and populations were subjected to targeted harvest for their meat and skins for at least the last century; fisheries are possibly the most significant threat to populations of marine elapids, with the highest numbers being exploited either accidentally, incidentally, or opportunistically in Southeast Asian fisheries targeting other seafood, including demersal trawl and squid fisheries. Southeast Asia is the core region for exploitation of marine elapids. Annual offtake is >225,000 individuals of at least 8 species in the Gulf of Thailand. Of 72 recognized marine elapids (all non‐CITES [Convention on International Trade in Endangered Species of Wild Fauna and Flora] species), Hydrophis curtus and Hydrophis cyanocinctus dominate the skin trade. Skins of H. curtus are traded mainly in East and Southeast Asia and, to some extent, Europe. Despite some baseline information on the trade of these species, the sustainability of their harvests, particularly in the context of the burgeoning and unmanaged nature of fisheries in the region, remains the major challenge. In an era of declining fish stocks, there has been an increasing trend to commercialize the harvest and use marine elapids that were once considered accidental bycatch and discarded. This trend will continue to pose a significant risk to these snakes unless appropriate fisheries and trade regulations are enforced. Applying the precautionary principle to prevent the overexploitation of sea snakes is an indispensable measure in which trade in regional populations should be regulated through CITES. Accordingly, management plans to identify core distribution regions of exploited species would be crucial for assigning national responsibilities to sustain species and populations in the long term.
A practical approach to meeting national obligations for sustainable trade under CITES
Authors: Vaidyanathan Tanvi , Foster Sarah J. , Ramkumar B. , Vincent Amanda C. J. 
Published: September 2024

AbstractReconciling conservation goals with sustainable resource use requires adaptive management strategies. The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) regulates global trade for species listed on Appendix II, partly by requiring member countries (parties) to ensure exports do not damage wild populations (called making positive “nondetriment findings” [NDFs]). Unfortunately, when parties find NDFs difficult, they often suspend legal trade, imposing economic costs and driving trade underground. To make it easier for parties to examine the detrimental nature of exports, we devised a spatial approach and applied it to seahorses (Hippocampus spp.) in Tamil Nadu, India, as an example. Our approach involves mapping answers to 5 key questions on species distribution (QA), pressures (QB), management measures (QC), management implementation (QD), and species’ population status (QE). We gathered data from fisher interviews and published literature. Seahorse abundance was greatest in southern Palk Bay and the northern Gulf of Mannar, primarily in seagrasses and coral reefs (QA). Fishing pressure was highest in Palk Bay, primarily from bottom trawlers and dragnetters operating in shallow seahorse habitats near the coastline (QB). Management measures including a marine protected area (MPA), bottom trawl exclusion zone, and closed season were theoretically in place (QC), but their implementation was poor (QD). Fishers reported seahorse catches in 85% of the area covered by the MPA and the exclusion zone; bottom trawlers were responsible for most violations. Seahorses were also captured in Sri Lankan waters, where bottom trawling is banned. Fisher reports indicated declining seahorse catches and reduced body sizes (QE), highlighting unsustainable exploitation. Our results highlight the need for better implementation of existing management measures before a positive NDF can be made and suggest mitigation beyond bans. Such pragmatic spatial analyses can help regulate exports at sustainable levels, supporting CITES implementation for its vast range of species.
Use of consumer insights to inform behavior change interventions aimed at illegal pet turtle trade in China
Authors: Zheng Wuji , Wan Anita Kar Yan , Chen Zhan , Clark Alexander , Court Caitlin , Gu Yuanlu , Park Toby , Reynolds Jake , Zhang Xiaoxi , Li Lishu , Lee Tien Ming 
Published: September 2024

AbstractIllegal poaching and overexploitation for the international pet trade are among the greatest threats to freshwater turtles in Southeast Asia. Expanding consumer research in China is crucial to filling knowledge gaps about the scale and structure of illegal trade and developing audience‐targeted and relevant interventions that may reduce demand for illegal turtles as pets. We applied mixed methods to provide a detailed understanding of the consumer side of the illegal pet turtle trade in China. We conducted 30 interviews with key stakeholders and online surveys (n = 2456) of turtle keepers via community forums. From these, we identified 3 core consumer groups based on their prior turtle‐keeping experience, species exposure, and potential for future purchases. We conducted a thematic qualitative analysis of concepts related to the capability, opportunity, motivation, and behavior (COM‐B) model to determine the factors influencing the illegal pet turtle trade and to identify barriers to illegal purchases. Specifically, we identified purchasers’ capabilities, opportunities, and motivations in the context of legality, enforcement risk, captive breeding, and impacts on wild population. We developed consumer journey maps (i.e., visual representations of customer's experiences throughout their buying journey) for core consumer groups. These maps illustrate the sequential behaviors and processes that consumers undertake when purchasing turtles, from initial exposure to sourcing, keeping, and providing a new home. Key factors influencing illegal purchases included convenient purchase channels, misguided cognition and motivations for pet keeping, and weak law enforcement. Effective interventions included messages focusing on shifting cognition and beliefs, increasing legal risk perception, and emphasizing stringent law enforcement, primarily delivered through online channels. Our results underscore the necessity for adaptable, audience‐tailored interventions to reduce consumer demand for illegal wildlife products. The mixed‐methods approach, combining quantitative and qualitative data, provided a comprehensive understanding of the target behavior and can inform the development of effective intervention strategies.
Determining the legality of newly described CITES‐listed species in the horticulture trade of tropical pitcher plants (Nepenthes)
Authors: Robinson Janine E. , Roberts David L. 
Published: September 2024

AbstractDue diligence is a fundamental component of ensuring a sustainable and legal wildlife trade that is also supportive of the livelihoods and businesses that depend on the trade. This is particularly true with species listed on the Convention on International Trade in Endangered Species (CITES) that are considered threatened or may become threatened by trade. Undertaking due diligence exercises requires access to information on which to base such decisions; however, the extent to which information is available is unclear. We used the trade in tropical pitcher plants (Nepenthes) for horticultural purposes as a case study to determine the extent to which information is available. A systematic survey of online trade was conducted for species described from 1996 to 2016. For the species found in trade, these were cross‐referenced with the CITES trade database, and inquiries were made to the relevant CITES Management Authorities and National Focal Points Access and Benefit Sharing (ABS). Of 83 newly described species, 61% were offered for sale online in 2018. Despite all Nepenthes species being listed on CITES, only 23% (n = 19) of the species being sold online were reported in trade on the CITES Trade Database, and only 3 were from the countries of origin. Thirty‐two of these species had no international trade recorded according to the database. Management authorities of CITES for the countries of origin confirmed trade had been permitted for 5 of 32 species. Lack of CITES records may be explained by trade under “Nepenthes spp.” or as exempt parts and derivatives. However, permits to collect and commercialize are likely to be required as part of the Nagoya Protocol on ABS from the Convention on Biological Diversity. The ABS National Focal Points were contacted to determine whether collection or commercialization permits had been issued for the remaining species. Only 2 of 7 focal points replied, and both stated no permits had been issued. Lack of traceability information or response related to the issuance of collection and commercialization permits is concerning and hinders the due diligence of businesses and consumers wanting to ensure their trade is legal, sustainable, and ethical.