bluuebunny/crossref_metadata_2025_split huggingface dataset:
A técnica de clip-wrap: uma revisão de literatura
Authors: Rodrigues Daniella Brito , Figueiredo Eberval Gadelha , Carvalho Viegas Maria Luana , Teixeira Saulo Araújo , Teixeira Manoel Jacobsen 
Published: January 2018

ResumoA técnica de clip-wrap é utilizada quando o neurocirurgião é confrontado com aneurismas que não podem ser clipados pelas técnicas tradicionais, por causa de colo largo, calcificação, placas ateroscleróticas, aneurismas fusiformes ou quando há vasos oriundos do corpo do aneurisma. Diversos tipos de materiais podem ser utilizados, incluindo algodão, gaze de musselina, músculo, cola de fibrina e cianoacrilato. Nesta revisão de literatura, os autores destacam os resultados obtidos por esses diferentes materiais, assim como as complicações e a eficácia em relação às taxas de ressangramento e ruptura no pós-operatório. Conclui-se, portanto, que a técnica de clip-wrap é segura e eficaz, associada com uma baixa taxa de complicações pós-operatórias. O método pode impedir ressangramento e representa melhoria quando comparado com a história natural da doença.
Acessos endoscópicos para lesões hipofisárias
Authors: Lizarazu Oroz Edson Flavio , Figueiredo Eberval Gadelha , Pinna Fabio de Rezende , Souza Anderson Rodrigo , Carvalho Viegas Maria Luana , Rodrigues Daniella Brito , Teixeira Manoel Jacobsen 
Published: January 2018

ResumoAo longo dos anos, a cirurgia minimamente invasiva avançou com a contribuição importante dos neurocirurgiões sobre a melhor opção para a abordagem terapêutica de tumores da região selar, partindo-se de uma cirurgia extremamente prejudicial, com alta morbidade e mortalidade, até a evolução de técnicas mais modernas, as quais dispõem de materiais mais adequados, que permitem ressecções completas com menor agressão às estruturas neurovasculares. Para praticá-las, é necessário um grupo de trabalho que envolva diferentes especialidades, como endocrinologia, oftalmologia, otorrinolaringologia, neurocirurgia e radioterapia, a fim de oferecer aos pacientes as melhores opções, garantindo atendimento individualizado, resolutivo e pouco agressivo. Há necessidade de um planejamento pré-operatório cuidadoso, com o uso de exames complementares avançados como ressonância magnética, tomografia computadorizada dos seios da face, dosagem sérica dos hormônios hipofisários e campimetria visual. Ainda, durante o procedimento cirúrgico, pode-se dispor de neuronavegação, tornando a cirurgia mais segura, especialmente nas reoperações. Por essas vantagens, a cirurgia transesfenoidal por microscopia convencional e por endoscopia é o procedimento atual de escolha para tratar tumores selares e fornecer adequada descompressão de estruturas neurais, com recuperação favorável mais rápida no pós-operatório em comparação com a abordagem transcraniana convencional.
Facial reanimation by hypoglossal-facial neurorrhaphy
Authors: Fernandes Yvens Barbosa , Ramina Ricardo , Fernandes Cyrino Hélio Sérgio , Prôa Júnior Marcílio Silva 
Published: January 2018

Abstract
Objective: Facial palsy may still occur after removal of large vestibular schwannomas. The aim of this paper is to describe the outcome of patients submitted to facial reanimation and make a concise revision about modern techniques available to reanimate a paralyzed face. Methods: A retrospective study of was performed about the surgical results of 12 patients submitted to hypoglossal-facial neurorrhaphy. These patients were submitted to radical removal of large vestibular schwannomas (> 3 cm) before and anatomic preservation of the facial nerve was not possible. Results: In 10 cases (83%) patients had a good outcome with House-Brackmann facial grading III. In two other cases the facial grading was IV and VI. All patients were follow-up for at least one year after the reanimation procedure. Conclusion: Hypoglossal-facial neurorrhaphy is a very useful technique to restore facial symmetry and minimize the sequela of a paralyzed face. Long last palsy seemed to be the main reason of poor outcome in two cases.
Parkinsonism-hyperpyrexia syndrome after bilateral deep brain stimulation surgery: case report in a Brazilian man
Authors: Dall’aglio Rocha Carlos Eduardo , Oliveira Fábio de Nazaré , Carlos da Silva Junior Sebastião , Meguins Lucas Crociati 
Published: January 2018

AbstractDeep brain stimulation is a surgical treatment that has provided remarkable therapeutic benefits for otherwise treatment-resistant movement and affective disorders, including advanced Parkinson disease. Levodopa medications are usually discontinued the night before surgery to localize the optimal response site to intraoperative macrostimulation. However, abrupt withdrawal of medication may result in severe side effects. On the present report, we describe the case of a 65 years-old man that evolved parkinsonism-hyperpyrexia syndrome following deep brain stimulation procedure for bilateral subthalamic nucleus after discontinuation of antiparkinsonian medications. Physicians should be aware of this life-threatening clinical conditions, once early diagnosis and reintroduction of medication improve patient's clinical condition significantly.
Hérnia discal cervical não traumática e Síndrome de Brown-Séquard. Relato de caso e revisão da literatura
Authors: Tavares Cléciton Braga , Sousa Emerson Brandão , Campbell Borges Igor Brenno , Soares Baldomero Pinto , Freire Neto Nelson Geraldo 
Published: January 2018

ResumoA Síndrome de Brown-Séquard (SBS) é caracterizada pela perda da função motora, propriocepção e sensibilidade vibratória ipsilateral e perda da sensibilidade tátil e dolorosa contralateral à hemissecção medular. É principalmente causada por fraturas da coluna vertebral ou tumores extramedulares. Hérnia discal cervical não traumática é uma etiologia rara, havendo 31 relatos em literatura indexada até o momento. Paciente do sexo masculino, 23 anos, admitido com parestesia em dimídio esquerdo e fraqueza no hemicorpo direito há cerca de 35 dias da internação. Sem relatos de trauma. Ao exame: consciente e orientado, hemiparesia à direita e hemi-hipoestesia tátil dolorosa à esquerda com nível motor e sensitivo em C7. Os exames de imagem evidenciaram um canal estreito cervical de C4-T1, presença de hérnia discal extrusa C5-C6 e hipersinal medular a esse nível. Foi submetido à discectomia e artrodese cervical anterior de C5-C6. No pós-operatório, evoluiu com tetraplegia flácida (nível motor/sensitivo em C8). Os exames de controle mostraram correto posicionamento do instrumental cirúrgico, ausência de hérnias discais e manutenção do hipersinal medular. Após oito meses de reabilitação e seguimento ambulatorial, permanece tetraparético. Descrevemos o primeiro caso brasileiro, em literatura indexada, de SBS causada por hérnia discal cervical não traumática. Há um predomínio pelo sexo masculino, a média de idade é de 45 anos e o disco intervertebral C5-C6 é o mais acometido. Microdiscectomia e fusão intersomática são as formas mais comuns de tratamento. Após a descompressão precoce, há um bom prognóstico, com recuperação da motricidade na maioria dos casos.
Importância da neuroestimulação medular no tratamento da síndrome do insucesso da cirurgia espinal
Authors: Gomes Isabela Palmeira , Ottoni da Silva Netto Otaviano , Matos Rodrigo Almeida , José da Silva Ledismar 
Published: January 2018

ResumoEletrodos vêm sendo utilizados desde 1967 para estimulação da coluna espinal (em inglês, spinal cord stimulation – SCS) no tratamento de dor crônica refratária em uma série de distúrbios dolorosos, entre eles a síndrome do insucesso da cirurgia espinal (em inglês, failed-back surgery syndrome – FBSS), caracterizada por dor persistente após cirurgias de coluna, principalmente laminectomia. Neste artigo, apresenta-se uma revisão sistemática da literatura sobre o estudo da neuromodulação no tratamento da FBSS, utilizando-se as plataformas dos portais virtuais PubMed e MedLine, com o objetivo de levantar evidências que corroborem a eficácia e a segurança desse procedimento para dor crônica lombar decorrente de FBSS. A seleção dos estudos, publicados no período entre janeiro de 2003 e janeiro de 2013, envolveu critérios de análise de eficácia (melhora da dor, com redução de 50% ou mais, utilizando a Escala Visual Analógica – VAS – ou outras similares) e de segurança (quando complicações foram citadas). Foram inicialmente identificados 186 artigos, entre os quais nove foram selecionados por preencherem os critérios de inclusão/exclusão, totalizando 313 pacientes. Em todos os trabalhos selecionados, observou-se melhora considerável da dor após os procedimentos neuromodulatórios. Conclui-se que, quando bem indicada, a SCS é mais eficaz do que a reoperação ou qualquer outro tipo de terapia conservadora no tratamento de dor crônica lombossacral.
Hygienische Abnahmeprüfungen raumlufttechnischer Anlagen unter Ruhebedingungen nach DIN 1946-4:1999-03 – eine retrospektive Auswertung
Authors: Friedrich Lena , Boeckelmann Irina 
Published: January 2018

Zusammenfassung
Hintergrund Die Erhaltung einer arbeitshygienisch und mikrobiologisch einwandfreien Raumluft, insbesondere in Operationssälen, soll durch die Verwendung von raumlufttechnischen Anlagen (RLTA) gewährleistet werden. Diese sollen u. a. die Zahl an Partikeln und Keimen in der Luft unter empfohlenen Grenzwerten halten. Um die regelrechte Funktion sicherzustellen, werden in festgelegten Abständen Kontrolluntersuchungen unter Ruhebedingungen, frühmorgens vor offiziellem OP-Beginn durchgeführt. Ziel dieser Studie ist es, den Effekt von verschiedenen Belüftungsarten auf die Raumluftqualität in einer medizinischen Einrichtung anhand der Untersuchungsergebnisse aufzuzeigen.
Methodik In der Studie wurden Messprotokolle von 34 Operationssälen aus einem Zeitraum von 10 Jahren ausgewertet. 29 Operationssäle wurden mittels turbulenzarmer Verdrängungsströmung belüftet, 5 mittels turbulenter Mischströmung. In allen 34 Operationssälen wurde die Luftreinheit bez. der Höhe an Luftpartikelzahlen und Luftkeimzahlen untersucht. Gemessen wurde an Messpunkten 10 mm unterhalb der Zuluftdecke, im Bereich des OP-Tisches und außerhalb der Zuluftdecke.
Ergebnisse Luftpartikelzahlen an der Zuluftdecke lagen zwischen 0/m³ Luft und 4441/m³ und überschritten den empfohlenen Grenzwert nie. Luftkeimzahlen hingegen lagen bei 0 KBE/m³ bis 200 KBE/m³. In 10,9% der Messungen wurde hier der Grenzwert überschritten. Die Werte in Raummitte waren generell höher als an der Zuluftdecke. Es lagen signifikante Unterschiede (p < 0,001) zwischen den Werten an der Zuluftdecke oder am Bereich des OP-Tisches und Werten außerhalb der Zuluftdecke vor. Der Kontaminationsgrad im Bereich des OP-Tisches war je nach Belüftungsartsystem unterschiedlich (p < 0,001).
Schlussfolgerungen Die Auswertungen verdeutlichen, dass durch die Verwendung von RLT-Anlagen i. d. R. eine partikel- und keimarme Raumluft gewährleistet werden kann. Die Verwendung turbulenzarmer Verdrängungsströmung scheint dabei bessere Ergebnisse zu liefern als die turbulente Mischströmung. Eine ausreichend große Zuluftdecke kann das OP-Gebiet, den Instrumententisch, das operierende Personal und den Patienten vor Kontamination schützen. Von einer Auswirkung der Luftkontamination auf postoperative Wundinfektionen ist jedoch laut aktuellem Kenntnisstand nicht auszugehen. Die Messmethodik sollte hinsichtlich Optimierungsmöglichkeiten überdacht werden.
Das Mikrobiom des Darms: Dysbiose
Authors: van der Giet Markus 
Published: January 2018

ZusammenfassungDas Mikrobiom des Darms wird gelegentlich auch als das „zweite menschliche Genom“ bezeichnet, da es eine hoch relevante Bedeutung in
Gesundheit, aber auch Krankheit hat. Im Darm gibt es eine beeindruckend große Anzahl von Bakterien, die eine enge Beziehung zum Wirt
pflegen. In bestimmten Situationen kann es zu einer Dysbiose kommen, was in der Konsequenz eine Schädigung des Wirtes nach sich ziehen kann.
In den Bakterien werden zahlreiche Substanzen gebildet, die vom gesunden Körper nach der Aufnahme unkompliziert verstoffwechselt bzw.
ausgeschieden werden können. Bei Patienten mit terminaler Nierenfunktionsstörung hingegen kommt es zum einen zu einer Veränderung des
Darmmikrobioms und gleichzeitig zu einer Akkumulation von aus dem Darm aufgenommenen Substanzen, die durch das veränderte Mikrobiom
produziert und nicht mehr eliminiert werden können. Dies führt zu einer Akkumulation von Urämietoxinen, die auch wesentlich zu dem
exzessiven, v. a. kardiovaskulären Mortalitätsrisiko der Patienten beitragen. Eine Strategie zur Hilfe für den betroffenen Patienten mag die
Wiederherstellung des Mikrobioms sein. In der vorliegenden Übersicht werden die Veränderungen des Mikrobioms und deren Auswirkungen
vorgestellt. Auch Ideen für eine Beeinflussung des Mikrobioms werden diskutiert.
A benchmark study of scoring methods for non-coding mutations
Authors: Drubay Damien , Gautheret Daniel , Michiels Stefan 
Published: January 2018

Abstract

Motivation
Detailed knowledge of coding sequences has led to different candidate models for pathogenic variant prioritization. Several deleteriousness scores have been proposed for the non-coding part of the genome, but no large-scale comparison has been realized to date to assess their performance.

Results
We compared the leading scoring tools (CADD, FATHMM-MKL, Funseq2 and GWAVA) and some recent competitors (DANN, SNP and SOM scores) for their ability to discriminate assumed pathogenic variants from assumed benign variants (using the ClinVar, COSMIC and 1000 genomes project databases). Using the ClinVar benchmark, CADD was the best tool for detecting the pathogenic variants that are mainly located in protein coding gene regions. Using the COSMIC benchmark, FATHMM-MKL, GWAVA and SOMliver outperformed the other tools for pathogenic variants that are typically located in lincRNAs, pseudogenes and other parts of the non-coding genome. However, all tools had low precision, which could potentially be improved by future non-coding genome feature discoveries. These results may have been influenced by the presence of potential benign variants in the COSMIC database. The development of a gold standard as consistent as ClinVar for these regions will be necessary to confirm our tool ranking.

Availability and implementation
The Snakemake, C++ and R codes are freely available from https://github.com/Oncostat/BenchmarkNCVTools and supported on Linux.

Supplementary information
Supplementary data are available at Bioinformatics online.
The complex kinematics of rotating star clusters in a tidal field
Authors: Tiongco Maria A , Vesperini Enrico , Varri Anna Lisa 
Published: January 2018

Abstract
We broaden the investigation of the dynamical properties of tidally perturbed, rotating star clusters by relaxing the traditional assumptions of coplanarity, alignment, and synchronicity between the internal and orbital angular velocity vector of their initial conditions. We show that the interplay between the internal evolution of these systems and their interaction with the external tidal field naturally leads to the development of a number of evolutionary features in their three-dimensional velocity space, including a precession and nutation of the global rotation axis and a variation of its orientation with the distance from the cluster centre. In some cases, such a radial variation may manifest itself as a counter-rotation of the outermost regions relative to the inner ones. The projected morphology of these systems is characterized by a non-monotonic ellipticity profile and, depending on the initial inclination of the rotation axis, it may also show a twisting of the projected isodensity contours. These results provide guidance in the identification of non-trivial features which may emerge in upcoming investigations of star cluster kinematics and a dynamical framework to understand some of the complexities already hinted by recent observational studies.
Survivorship care planning in neuro-oncology
Authors: Leeper Heather E , Acquaye Alvina A , Bell Susan , Clarke Jennifer L , Forst Deborah , Laack Nadia N , Link Michael J , Taylor Jennie W , Armstrong Terri S 
Published: January 2018

Abstract
Cancer patient survivorship has become a significant topic within oncology care for both adult and pediatric patients. Starting in 2005, the Institute of Medicine recommended the use of survivorship care plans to assist patients transitioning from active treatment to the posttreatment phase of their cancer care, a critical time for many patients. Since 2014 there has been a mandate within the United States for adult cancer patients treated with curative intent to receive survivorship care plans comprised of a treatment summary and a follow-up plan to facilitate a better understanding among patients of what to expect after treatment. In addition to a general oncology survivorship care plan, specific care plans have been created for breast, lung, prostate, and colon cancers, as well as lymphoma. A survivorship care plan specific to adult neuro-oncology has been developed by a multidisciplinary and interprofessional committee, with approval from the Society for Neuro-Oncology Guidelines Committee. It has been published in compendium with this review of survivorship care planning and available as a fillable PDF on the Society of Neuro-Oncology Guidelines Endorsement web page (https://www.soc-neuro-onc.org/SNO/Resources/Survivorship_Care_Plan.aspx). Implementation of this survivorship care plan provides a unique opportunity to begin addressing the range of survivorship issues our neuro-oncology patients navigate from diagnosis to end of life.
Internal Podalic Version and Breech Extraction
Authors: Cornette Jérôme M. J. , Erkamp Jan S. 
Published: January 2018

BACKGROUND:
Experience with internal podalic version and breech extraction is diminishing, especially in the younger generation of obstetricians. Simulation training is essential to teach and maintain these skills.

INSTRUMENT:
We present a mannequin-based simulation method that enhances realistic sensations during training.

EXPERIENCE:
By positioning the fetal mannequin into a thin plastic bag filled with water, the impression of palpating, grabbing, and pulling the fetal feet through the plastic bag is similar to reaching feet through intact membranes. The unique approach of this realistic simulation model makes the experience fun and memorable, which contributes to the didactic value and success of the model.

CONCLUSION:
The simulation model we present mimics the situation and sensation obstetricians experience while performing internal podalic version and breech extraction.
Preterm Birth and Gestational Length in Four Race–Nativity Groups, Including Somali Americans
Authors: Oliver Emily A. , Klebanoff Mark , Yossef-Salameh Lina , Oza-Frank Reena , Moosavinasab Soheil , Reagan Patricia , Muglia Louis , Buhimschi Catalin S. , Buhimschi Irina A. 
Published: January 2018

OBJECTIVE:
To compare preterm birth rates and gestational length in four race–nativity groups including Somali Americans.

METHODS:
Using a retrospective cohort study design of Ohio birth certificates, we analyzed all singleton births between 2000 and 2015 from four groups of women categorized as U.S.-born, non-Hispanic white (USBW), U.S.-born, non-Hispanic black (USBB), African-born black (ABB, primarily of West African birth country), and Somalia-born (SB). An algorithm trained on maternal names was used to confirm Somali ethnicity. Gestational length was analyzed as completed weeks or aggregated by clinically relevant periods. Risk of spontaneous and health care provider–initiated preterm birth was calculated in a competing risk model.

RESULTS:
Births to women in the designated groups accounted for 1,960,693 births (USBW n=1,638,219; USBB n=303,028; ABB n=10,966, and SB n=8,480). Women in the SB group had a lower preterm birth rate (5.9%) compared with women in the USBB (13.0%), ABB (8.4%), and USBW (7.9%) groups (P<.001). Women in the SB group had a higher frequency of postterm pregnancy (5.8% vs less than 1%, P<.001 for all groups). The lower rate of preterm birth in the SB group was unrelated to differences in parity or smoking or whether preterm birth was spontaneous or health care provider–initiated. The lower rate of preterm birth and tendency for prolonged gestation was attenuated in ethnic Somali women born outside Somalia.

CONCLUSION:
We report a positive disparity in preterm birth and a tendency for prolonged gestation for ethnic Somali women in Ohio. Etiologic studies in multiethnic cohorts aimed to uncover the sociobiological determinants of gestational length may lead to practical approaches to reduce prematurity in the general population.
Quality Assurance Practices in Obstetric Care
Authors: Lundsberg Lisbet S. , Lee Henry C. , Dueñas Grace Villarin , Gregory Kimberly D. , Grossetta Nardini Holly K. , Pettker Christian M. , Illuzzi Jessica L. , Xu Xiao 
Published: January 2018

OBJECTIVE:
To assess hospital practices in obstetric quality management activities and identify institutional characteristics associated with utilization of evidence-supported practices.

METHODS:
Data for this study came from a statewide survey of obstetric hospitals in California regarding their organization and delivery of perinatal care. We analyzed responses from 185 hospitals that completed quality assurance sections of the survey to assess their practices in a broad spectrum of quality enhancement activities. The association between institutional characteristics and adoption of evidence-supported practices (ie, those supported by prior literature or recommended by professional organizations as beneficial for improving birth outcome or patient safety) was examined using bivariate analysis and appropriate statistical tests.

RESULTS:
Most hospitals regularly audited adherence to written protocols regarding critical areas of care; however, 77.7% and 16.8% reported not having written guidelines on diagnosis of labor arrest and management of abnormal fetal heart rate, respectively. Private nonprofit hospitals were more likely to have a written protocol for management of abnormal fetal heart rate (P=.002). One in 10 hospitals (9.7%) did not regularly review cases with significant morbidity or mortality, and only 69.0% regularly tracked indications for cesarean delivery. Moreover, 26.3%, 14.3%, and 8.7% of the hospitals reported never performing interprofessional simulations for eclampsia, shoulder dystocia, or postpartum hemorrhage, respectively. Teaching status was associated with more frequent simulations in these three areas (P≤.04 for all), while larger volume was associated with more frequent simulations for eclampsia (P=.04).

CONCLUSION:
Hospitals in California engage in a wide range of practices to assure or improve quality of obstetric care, but substantial variation in practice exists among hospitals. There is opportunity for improvement in adoption of evidence-supported practices.