bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer‐provided problem management plus (PM+) and case management for Arabic‐speaking and Farsi‐speaking refugees and asylum seekers in Greece
Authors: Papathanasiou Chrysovalantis , Kougioumtzi Aikaterini 
Published: September 2024

AbstractAn increasingly common response to the lack of specialist mental health services for refugees and asylum seekers in European host countries is peer‐supported services. This study examined the association between a peer‐provided psychosocial intervention and psychological symptom reduction among refugees and asylum seekers in Greece. The intervention consisted of Problem Management Plus (PM+) and peer case management sessions delivered by a team of Community Psychosocial Workers (trained refugees). The sample consisted of 173 participants, comprising Arabic and Farsi speakers, male and female participants, recognized refugees and asylum seekers. Anxiety, depression, and psychological distress were measured before and after the intervention using the Patient Health Questionnaire‐9, Generalized Anxiety Disorder‐7, and Psychological Outcome Profiles scales, respectively. Repeated measures analysis of variance was adopted to evaluate the difference in the degree of change across patient characteristics over the follow‐up period. The level of statistical significance was set at p < .05, and analyses were conducted using SPSS statistical software (version 26.0). Significant decreases were found in all postintervention scores, indicating significant decreases in anxiety and depression symptoms as well as in psychological distress following the peer‐provided psychosocial intervention, which included emotional support and social care. Large effect sizes were found at all scales. The findings support the notion that there is an association between the implemented intervention and symptom reduction in refugees. For future research, a randomized controlled trial is proposed as a study protocol.
Association between Higher Intake of Flavonols and Lignans and Better Mood: Evidence from Dietary and Biomarker Evaluation in Healthy Individuals
Authors: Ma Xuemei , Xu Yifan , Li Yong , Gibson Rachel , Williams Claire , Lawrence Andrew J. , Nosarti Chiara , Dazzan Paola , Rodriguez‐Mateos Ana 
Published: September 2024

ScopeThe aim of this study is to investigate associations between (poly)phenol consumption, circulating (poly)phenol metabolites, and mood states in healthy individuals.Methods and resultsThe study included 333 healthy individuals. Mood state was assessed with the Positive and Negative Affect Schedule questionnaire. Dietary (poly)phenol intake was estimated matching food consumption data collected using a Food Frequency Questionnaire(FFQ) with a comprehensive in‐house (poly)phenol database. A total of 102 (poly)phenol metabolites were quantified in fasting plasma and 24 h urine samples by Liquid Chromatography‐Mass Spectrometry using a validated method. A higher intake of lignans, flavanones, and flavonols estimated from FFQs was associated with positive mood after adjusting for age and sex (β: 0.118 to 0.134). A total of 11 urinary (poly)phenol metabolites, including lignan and flavonol metabolites were associated with less negative mood (β: −0.387 to −0.205). No association was found between mood and plasma (poly)phenols.Conclusion A higher consumption of lignans flavanones and flavonols is associated with a better mood, while certain urinary metabolites are associated with less negative mood. The lack of associations between fasting plasma (poly)phenols and mood may be due to their transient nature incirculation compared with 24 h urinary metabolites, which reflect longer‐term exposure.
The use of electrical stimulation to enhance recovery following peripheral nerve injury
Authors: Hardy Paige B. , Wang Bonnie Y. , Chan K. Ming , Webber Christine A. , Senger Jenna‐Lynn B. 
Published: September 2024

AbstractPeripheral nerve injury is common and can have devastating consequences. In severe cases, functional recovery is often poor despite surgery. This is primarily due to the exceedingly slow rate of nerve regeneration at only 1–3 mm/day. The local environment in the distal nerve stump supportive of nerve regrowth deteriorates over time and the target end organs become atrophic. To overcome these challenges, investigations into treatments capable of accelerating nerve regrowth are of great clinical relevance and are an active area of research. One intervention that has shown great promise is perioperative electrical stimulation. Postoperative stimulation helps to expedite the Wallerian degeneration process and reduces delays caused by staggered regeneration at the site of nerve injury. By contrast, preoperative “conditioning” stimulation increases the rate of nerve regrowth along the nerve trunk. Over the past two decades, a rich body of literature has emerged that provides molecular insights into the mechanism by which electrical stimulation impacts nerve regeneration. The end result is upregulation of regeneration‐associated genes in the neuronal body and accelerated transport to the axon front for regrowth. The efficacy of brief electrical stimulation on patients with peripheral nerve injuries was demonstrated in a number of randomized controlled trials on compressive, transection and traction injuries. As approved equipment to deliver this treatment is becoming available, it may be feasible to deploy this novel treatment in a wide range of clinical settings.
A comparison of micromorphic gradient‐extensions for anisotropic damage
Authors: van der Velden Tim , Brepols Tim , Reese Stefanie , Holthusen Hagen 
Published: September 2024

AbstractThe modeling of inelastic phenomena with tensor‐valued internal variables requires a regularization to counteract mesh dependence. Here, we consider the regularization of anisotropic damage at finite strains and seek for an efficient formulation based on a reduced number of nonlocal degrees of freedom. We, thus, equip the brittle version of an anisotropic model with different gradient‐extensions in the micromorphic framework using a full and a reduced regularization of the damage tensor. The models are compared in the structural simulation of an asymmetrically notched specimen with a perforated shear band section. High agreement is observed between the full and the reduced regularization with two nonlocal degrees of freedom. Furthermore, we present a novel study of the evolution of the reduced micromorphic field variables.
A microstructural thermo‐elastoplastic analysis of the mushy zone during laser beam welding
Authors: Hartwig Philipp , Scheunemann Lisa , Schröder Jörg 
Published: September 2024

AbstractAs a modern method of contact free fusion, laser beam welding has gained importance in recent years. This is due to both the possibiliy of a high advance speed of the laser and low thermal distortion of the components compared to other welding processes, see Dal and Fabbro. These beneficial process properties follow from a focused laser, which thus results in a precise energy input. In addition, laser beam welding processes can be automated which makes the process attractive for a wide range of applications, cf. Dilthey. Nevertheless, various influences, like the temperature gradient, the chemical composition or process parameters, may have an effect on the occurrence of so‐called solidification cracks. Solidification cracks arise during solidification and occur in the area of the mushy zone, which is located behind the melt pool. The material behavior in the mushy zone is governed by a dendritic morphology. Due to this, liquid phase inclusions may occur in some parts of the mushy zone, see Hills et al. When these trapped areas solidify, no further liquid phase can follow and a negative pressure is created. The resulting stresses can then lead to solidification cracks. In further studies, the geometry of the dendritic morphology will be generated on the basis of previous phase field simulations. These describe the dendrite growth controlled by the chemical concentration. The resulting geometry will then be simulated using the possibilities of a thermo‐elastoplastic material model, which will enable temperature‐driven imitation of growth. This contribution addresses the evolving state of the dendritic microstructure in a simplified manner. Therefore, for the first study, a simplified morphology is used, that is, no secondary arms and an elliptical geometry of the dendrites is assumed. Thermal as well as elastoplastic effects are already taken into account, in order to represent the inherent stress and strain states in the microstructure. These may be related to critical states leading to failure in the future.
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions
Authors: Cyrta Joanna , Dermawan Josephine K , Tauziède‐Espariat Arnault , Liu Ting , Rosenblum Marc , Shroff Seema , Katabi Nora , Cardoen Liesbeth , Guillemot Delphine , Masliah‐Planchon Julien , Hoare Owen , Delattre Olivier , Bale Tejus , Bourdeaut Franck , Antonescu Cristina R 
Published: September 2024

AbstractCREB gene family (ATF1, CREB1, CREM) fusions with either EWSR1 or FUS gene partners drive the pathogenesis of a wide range of neoplasms, including various soft tissue tumors, intracranial myxoid mesenchymal tumors (IMMTs), hyalinizing clear cell carcinoma (HCCC), and rare mesotheliomas. Recently, a SMARCA2::CREM fusion was reported in one case each of IMMT and HCCC. In this study, we expand the clinicopathologic and molecular spectrum of these neoplasms by describing three additional cases with SMARCA2::CREM and one with a novel SMARCA4::CREM fusion, highlighting the recurrent potential of additional CREB gene fusion partners beyond FET family members. To evaluate if these fusions define a new pathologic entity, we performed a comprehensive genomic and methylation analysis and compared the results to other related tumors. Tumors occurred in children and young adults (median age 20 years) and spanned a broad anatomic distribution, including soft tissue, intracranial, head and neck, and prostatic urethra. Microscopically, the tumors shared an undifferentiated round to epithelioid cell phenotype and a hyalinized fibrous stroma. Immunohistochemically, a polyphenotypic profile was observed, with variable expression of SOX10, desmin, and/or epithelial markers. No targetable genomic alterations were found using panel‐based DNA sequencing. By DNA methylation and transcriptomic analyses, tumors grouped closely to FET::CREB entities, but not with SMARCA4/SMARCB1‐deficient tumors. High expression of CREM by immunohistochemistry was also documented in these tumors. Patients experienced local recurrence (n = 2), locoregional lymph node metastases (n = 2), and an isolated visceral metastasis (n = 1). Overall, our study suggests that SMARCA2/4::CREM fusions define a distinct group of neoplasms with round cell to epithelioid histology, a variable immunoprofile, and a definite risk of malignancy. Larger studies are needed to further explore the pathogenetic relationship with the FET::CREB family of tumors. © 2024 The Pathological Society of Great Britain and Ireland.
Complications and long‐term impact of early life pneumonia
Authors: Ayuk Adaeze C. 
Published: September 2024

AbstractPneumonia is an infection affecting the lower airway, where the air sacs are filled with mucus and pus; and typically presents with cough, fever, and fast breathing. Pneumonia is estimated to be the leading cause of mortality in children under five worldwide with 120 million episodes result in 1 million deaths globally. The Low‐Income and Middle‐Income Countries (LMICs) are more affected. In a study in southeast Nigeria, bronchopneumonia accounted for 41.9%, of the cases admitted in the tertiary hospitals and in another hospital based study among children, pneumonia had the highest respiratory admission rates at 34.0%. Pneumonia can be caused by various organisms: Bacterial (Streptococcus, staphylococcus etc), Viral (RSV) and recently COVID 19 pneumonia. RSV has been noted globally to be a major cause of childhood lower respiratory tract infection, with morbidity/mortality occurring in 99% of (LMICs). Some of the long term sequalae are discussed.
Inhaled corticosteroid delivery is markedly affected by breathing pattern and valved holding chamber model
Authors: Ojanperä Laura , Lehtimäki Lauri , Huhtala Heini , Csonka Péter 
Published: September 2024

AbstractBackgroundThere is a scarcity of high‐quality research on the efficient delivery of inhaled corticosteroids using valved holding chambers (VHCs) in children.MethodsThe delivered dose (DD) of fluticasone from a metered dose inhaler (pMDI) was tested using four VHCs: AeroChamber plus Flow‐Vu (AC), Babyhaler (BH), EasyChamber (EC), and Optichamber Diamond (OD). The in vitro setup included an anatomical child throat model, Next Generation Impactor, and a breathing simulator to generate tidal breathing of a four and a 6‐year‐old child, and adult type single inhalation.ResultsOD showed the lowest proportion of fluticasone trapped in the throat with all breathing patterns. AC showed similar fine particle dose (FPD) in the respirable range (1–5 µm) irrespective of the breathing pattern. For BH, the median FPD 1–5 µm was highest during adult breathing. OD and EC showed higher overall DD and higher doses in the 1–5 µm range with paediatric breathing profiles compared to adult inhalation. The median DD and FPD 1–5 µm were significantly lower with BH compared to any other VHCs during tidal breathing. Compared to EC, the FPD of the other VHCs were skewed towards <2 µm particles.ConclusionFluticasone delivery is markedly affected by breathing pattern and VHC model. The observed differences in throat deposition and FPD delivered may have significant clinical implications for side effects and controlling airway inflammation. All VHCs intended for paediatric use should undergo testing using internationally recognised standardised methods incorporating clinically relevant paediatric breathing patterns.
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion‐transporting polypeptides (OATP1B1 and OATP2B1)
Authors: Dombi Ágnes , Kaci Hana , Valentová Kateřina , Bakos Éva , Özvegy‐Laczka Csilla , Poór Miklós 
Published: September 2024

AbstractMyricetin (MYR) and ampelopsin (AMP, or dihydromyricetin) are flavonoid aglycones found in certain plants and dietary supplements. During the presystemic biotransformation of flavonoids, mainly sulfate and glucuronide derivatives are produced, which are the dominant metabolites in the circulation. In this study, we tested the interactions of MYR, myricetin‐3′‐O‐sulfate (M3′S), AMP, and ampelopsin‐4′‐O‐sulfate (A4′S) with human serum albumin (HSA), cytochrome P450 enzymes (CYPs), and organic anion‐transporting polypeptides (OATPs) using in vitro models, including the recently developed method for measuring flavonoid levels in living cells. M3′S and MYR bound to albumin with high affinity, and they showed moderate displacing effects versus the Site I marker warfarin. MYR, M3′S, AMP, and A4′S exerted no or only minor inhibitory effects on CYP2C9, CYP2C19, and CYP3A4 enzymes. M3′S and MYR caused considerable inhibitory actions on OATP1B1 at low micromolar concentrations (IC50 = 1.7 and 6.4 μM, respectively), while even their nanomolar levels resulted in strong inhibitory effects on OATP2B1 (IC50 = 0.3 and 0.4 μM, respectively). In addition, M3′S proved to be a substrate of OATP1B1 and OATP2B1. These results suggest that MYR‐containing dietary supplements may affect the OATP‐mediated transport of certain drugs, and OATPs are involved in the tissue uptake of M3′S.
A Concise Review on Microwave Assisted Synthetic Approches of Sulfonamides
Authors: Meena Lakshman R. , Soni Jigar Y. , Battula Satyanarayana 
Published: September 2024

AbstractSulfonamides have been played a critical role in the history of medicinal chemistry development for decades. In particular, sulfonamides display a broad spectrum in pharmaceutical drugs synthesis. This review presents a short discussion of the microwave‐assisted synthetic approaches, enhancement of sulfonamides moieties and their pharmacological applications are being discussed. During the past few decades, microwave‐assisted technology in organic synthesis has been highlighted to introducing ‐SO2NH functional group in the multi synthetic routes for the development of bioactive molecule and also assisted in the estimation of their credible mechanistic routes for the reactions.
Synthesis and Characterization of Air‐Stable Palladium(II) and Copper(I) Ph‐Garphos Complexes and their Applications to Asymmetric Catalysis
Authors: Lorraine Shannen C. , Green Kerry‐Ann , Abdur‐Rashid Kamaluddin , Lough Alan J. , Maragh Paul T. 
Published: September 2024

AbstractAir‐stable palladium(II) and copper(I) complexes containing the 4,4′,6,6′‐tetramethoxybiphenyl‐2,2′‐diyl)bis(diphenylphosphine) ligands, (R)‐Ph‐Garphos ((R)‐L1) and ((S)‐Ph‐Garphos ((S)‐L1), were synthesized and characterized by 1H‐, 13C‐, and 31P{1H} NMR spectroscopy and elemental analyses. The PdCl2((R)‐Ph‐Garphos) ((R)‐1) and PdCl2((S)‐Ph‐Garphos) ((S)‐1) complexes were assessed for the Suzuki‐Miyaura cross‐coupling of aryl halides with phenylboronic acid under ambient conditions, or naphthyl substrates under reflux. X‐ray crystal structures of the copper complexes revealed that [Cu((R)‐Ph‐Garphos)I] ((R)‐2) crystallized as a three‐coordinate monomer in the orthorhombic space group P212121 whereas [Cu((S)‐Ph‐Garphos)I] ((S)‐2) crystallized as a tetrahedral (μ‐I) dimer in the same crystal system. The synthesis of the analogous [Cu((R)‐Ph‐Garphos)OAc] ((R)‐3) is also described. Complexes (R)‐2 and (R)‐3 were evaluated for the asymmetric hydrosilylation of ketones wherein enantioselectivities of up to 83 % ee were achieved.
The Role of Silanization of Barium Strontium Titanate Nanopowders on the Dielectric Constant and Thermal Stability of Epoxy Nanocomposites
Authors: Chu Ngoc Chau , Phan Thi Tuyet Mai , Bui Duc Trung , Xuan Hoan Nguyen , Carriere Pascal 
Published: September 2024

AbstractThis paper reports polymer composites′ microstructure and dielectric properties based on an epoxy resin matrix containing different amounts (from 2–10 wt. %) of barium strontium titanate nanoparticles. (Ba,Sr)TiO3 was prepared using the hydrothermal method, showing an average particle size of 100 nm. The composites′ thermal properties and morphology were characterized using thermogravimetric analysis, differential scanning calorimetry, and scanning electron microscopy. Our studies show that the (Ba,Sr)TiO3 nanoparticles were well dispersed in the epoxy resin matrix thanks to controlled silane functionalization. Accordingly, the glass transition temperature (Tg) value of the nanocomposites was found to be 159.0 °C at 10 wt. % (Ba,Sr)TiO3 loading and is higher than the neat epoxy resin Tg (Tg=154.7 °C). Moreover, the dielectric composite properties were investigated comprehensively via a wide range of frequencies from 10 Hz to 100 kHz. The results indicate that (Ba,Sr)TiO3 nanopowders and the surface modifying filler play a crucial role in the significant increase of the dielectric constants, approximately 1.5 times at the optimum added amount (Ba,Sr)TiO3. The limited functionalization of (Ba,Sr)TiO3 nanoparticles by the silane affords to control the nanocomposite dielectric loss. Furthermore, the nanocomposites also exhibited good thermal stability.
Strong Laser Emission Modulation by Coherent Perfect Absorption Inside Complex‐Coupled Distributed Feedback Laser Diodes
Authors: Liang Yaoyao , Coudevylle Jean‐René , Benisty Henri , Ramdane Abderrahim , Lupu Anatole 
Published: September 2024

AbstractThe proof‐of‐concept of the exploitation of Coherent Perfect Absorption (CPA) in electrically‐injected distributed‐feedback laser sources is reported. Capitalizing on the essence of CPA as “light extinction by light”, an integrated laser‐modulator scheme emerges. The key ingredient compared to conventional single‐frequency laser diodes is a careful periodic in‐phase modulation of both real and imaginary parts of the complex grating index profile that enables both single‐frequency operation and 40 dB line purity at the Bragg frequency. It is shown that this combination is most apt for the operation of CPA as a modulation mechanism that respects the laser spectral purity. The specific proof‐of‐concept is based on an ultra‐short external cavity formed by a metallic micro‐mirror, whose role is to generate the second beam of more conventional CPA interferometric approaches. The implemented complex‐coupled grating is compatible with existing industrial technologies and promising for real‐life laser source applications. Furthermore, the concept can be directly transferred to other material platforms and other wavelengths ranging from terahertz to ultraviolet.
1D MXenes: Synthesis, Properties, and Applications
Authors: Kumar Sunil , Mehdi Syed Muhammad Zain , Seo Yongho 
Published: September 2024

AbstractThe fascinating properties and versatile nature of 2D MXenes have generated significant interest in the scientific community. This has led to extensive research on expanding these materials into 1D and 0D forms. This review investigates the synthesis, properties, and applications of 1D MXenes, elucidating their potential across various fields. 1D MXenes, including nanowires, nanoribbons, nanorods, and nanotubes, inherit the remarkable properties of their 2D counterparts while also exhibiting unique anisotropic characteristics that enhance their performance in various applications. The review explores various methods for synthesizing 1D MXenes and examines their structural, electronic, and optical properties. The transition from 2D to 1D results in MXenes that offer superior properties, which are advantageous for various next‐generation systems. The increased aspect ratio and surface area of 1D MXenes broaden their usage in energy storage, photothermal therapy, oxygen evolution reactions (OER), hydrogen evolution reactions (HER), oxygen reduction reactions (ORR), microwave absorption, filtration membranes, gas sensors, metal detection, etc. The review also addresses the challenges associated with 1D MXenes, such as limited synthesis methods, scalable production, size customization, preservation of structural integrity, and stability. Furthermore, potential opportunities and future directions in the field of 1D MXenes have also been proposed.
Multiple Topological Phases with Electronic Correlation in Intrinsic Ferromagnetic Semimetal VI3 Monolayer
Authors: Zhao Xiaosong , An Yukai 
Published: September 2024

Abstract2D topological materials with magnetic ordering have become hot topics due to their nontrivial band topology and quantum states. In this work, the second‐order topological states and evolution of linear band crossing are successfully predicted utilizing the effective k· p and tight binding models in the intrinsic ferromagnetic VI3 monolayer under various effective Hubble interaction Ueff. Upon inclusion of spin orbit coupling, a small bandgap (Eg‐1) of 12.7 meV is opened with a Chern invariant C = −1 at Ueff = 0 eV. The Eg‐1 undergoes a transition from the non‐trivial state to trivial state at Ueff = 0.80 eV, accompanied by the appearance of Dirac cone. Remarkably, the increase of Ueff causes the band inversion and adjustment of crystal symmetry, resulting in two unreported coexisting topological bandgaps (Eg‐2 and Eg‐3). Furthermore, a gapless node‐loop appears at Ueff = 1.06 eV and disappears at Ueff = 1.09 eV around Γ point. Moreover, for the first time, the existence of second‐order topological states with quantized corner fractional charges (e/3) is also observed in the VI3 monolayer at Ueff ≥0.96 eV. These results make the VI3 monolayer a compelling candidate for exploring topological devices.