bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insurance Status Among Adults With Hypertension—The Impact of Underinsurance
Authors: Fang Jing , Zhao Guixiang , Wang Guijing , Ayala Carma , Loustalot Fleetwood 
Published: December 2016

Background

Hypertension is a major risk factor for heart disease and stroke. Health insurance coverage affects hypertension treatment and control, but limited information is available for
US
adults with hypertension who are classified as underinsured.

Methods and Results
Using Behavioral Risk Factor Surveillance System 2013 data, we identified adults with self‐reported hypertension. On the basis of self‐reported health insurance status and health care–related financial burdens, participants were categorized as uninsured, underinsured, or adequately insured. Proxies for health care received included whether they reported taking antihypertensive medications and whether they visited a doctor for a routine checkup in the past year. We assessed the association between health insurance status and health care received, adjusting for selected sociodemographic characteristics. Among 123 257 participants from 38 states and District of Columbia with self‐reported hypertension, 12% were uninsured, 26% were underinsured, and 62% were adequately insured. In adjusted models using adequately insured participants as referent, both uninsured (adjusted odds ratio, 0.39; 95% CI, 0.35–0.43) and underinsured (0.83, 0.76–0.89) participants were less likely to report using antihypertensive medication than those of adequately insured participants. Similarly, adjusted odds ratio of visiting a doctor for routine checkup in the past year were 0.25 (0.23–0.28) for those who were uninsured and 0.78 (0.72–0.84) for those who were underinsured compared to those with adequate insurance.

Conclusions
Uninsured and underinsured participants with hypertension were less likely to report receiving care compared to those with adequate insurance coverage. Disparities in health care coverage may necessitate targeted interventions, even among people with health insurance.
Development of a Smartphone‐Enabled Hypertension and Diabetes Mellitus Management Package to Facilitate Evidence‐Based Care Delivery in Primary Healthcare Facilities in India: The mPower Heart Project
Authors: Ajay Vamadevan S. , Jindal Devraj , Roy Ambuj , Venugopal Vidya , Sharma Rakshit , Pawar Abha , Kinra Sanjay , Tandon Nikhil , Prabhakaran Dorairaj 
Published: December 2016

Background

The high burden of undetected and undertreated hypertension and diabetes mellitus is a major health challenge worldwide. The
mP
ower Heart Project aimed to develop and test a feasible and scalable intervention for hypertension and diabetes mellitus by task‐sharing with the use of a mobile phone–based clinical decision support system at Community Health Centers in Himachal Pradesh, India.

Methods and Results

The development of the intervention and mobile phone–based clinical decision support system was carried out using mixed methods in five Community Health Centers. The intervention was subsequently evaluated using pre–post evaluation design. During intervention, a nurse care coordinator screened, examined, and entered patient parameters into mobile phone–based clinical decision support system to generate a prescription, which was vetted by a physician. The change in systolic blood pressure, diastolic blood pressure, and fasting plasma glucose (
FPG
) over 18 months of intervention was quantified using generalized estimating equations models. During intervention, 6797 participants were enrolled. Six thousand sixteen participants had hypertension (mean systolic blood pressure: 146.1 mm Hg, 95%
CI
: 145.7, 146.5; diastolic blood pressure: 89.52 mm Hg, 95%
CI
: 89.33, 89.72), of which 3152 (52%) subjects were newly detected. Similarly, 1516 participants had diabetes mellitus (mean
FPG
: 177.9 mg/dL, 95%
CI
: 175.8, 180.0), of which 450 (30%) subjects were newly detected. The changes in systolic blood pressure, diastolic blood pressure, and
FPG
observed at 18 months of follow‐up were −14.6 mm Hg (95%
CI
: −15.3, −13.8), −7.6 mm Hg (
CI
: −8.0, −7.2), and −50.0 mg/dL (95%
CI
: −54.6, −45.5), respectively, and were statistically significant even after adjusting for age, sex, and Community Health Center.

Conclusions
A nurse‐facilitated, mobile phone–based clinical decision support system‐enabled intervention in primary care was associated with improvements in blood pressure and blood glucose control and has the potential to scale‐up in resource poor settings.

Clinical Trial Registration

URL
:
https://www.clinicaltrials.gov
. Unique identifiers:
NCT
01794052. Clinical Trial Registry—India:
CTRI
/2013/02/003412.
Atmospheric Global Circuit Variations from Vostok and Concordia Electric Field Measurements
Authors: Burns G. B. , Frank-Kamenetsky A. V. , Tinsley B. A. , French W. J. R. , Grigioni P. , Camporeale G. , Bering E. A. 
Published: December 2016

Abstract
Atmospheric electric field measurements from the Concordia station on the Antarctic Plateau are compared with those from Vostok (560 km away) for the period of overlap (2009–11) and to Carnegie (1915–29) and extended Vostok (2006–11) measurements. The Antarctic data are sorted according to several sets of criteria for rejecting local variability to examine a local summer-noon influence on the measurements and to improve estimates of the global signal. The contribution of the solar wind influence is evaluated and removed from the Vostok and Concordia measurements. Simultaneous measurements yield days when the covariability of the electric field measurements at Concordia and Vostok exceeds 90%, as well as intervals when significant local variability is apparent. Days of simultaneous changes in shape and mean level of the diurnal variation, as illustrated in a 5-day sequence, can be interpreted as due to changes in the relative upward current output of the electrified cloud generators predominating at low latitudes. Smaller average local meteorological influences are removed from the larger Vostok dataset, revealing changes in the shape of monthly average diurnal variations, which are similarly attributed to changes in predominantly low-latitude convection from month to month.
Tornado Warning Response and Perceptions among Undergraduates in Nebraska
Authors: Jauernic Sabrina T. , Van Den Broeke Matthew S. 
Published: December 2016

AbstractFew studies show how university students perceive and respond to tornado warnings. Lacking in the literature are investigations of what influences perceptions of tornado risk among this population and how these perceptions may influence actions. Through an online survey of 640 undergraduates enrolled at a large university in Nebraska, significant relationships were found between student demographics, perceptions, and response actions. Tornado mythology relevant to the local city influenced perceptions so that students felt the city was less at risk than surrounding rural land. Confirming risk before sheltering remained popular, with some students choosing to never seek shelter during a warning. International students were more likely to initially seek shelter during a warning but had difficulty interpreting warning polygons or accurately choosing the best safety actions. Tornado-related education resulted in international students being more likely to have safety plans and shelter in more appropriate locations. Most domestic students correctly identified safe areas in which to shelter, but fewer knew the precise meaning of a tornado warning polygon. Parents/guardians and the school were the most popular tornado knowledge sources for domestic students, while friends and self-education were popular with international students. Respondents seemed willing to learn more about tornadoes and perceived a lack of tornado-related resources available on campus. This implies that more thorough tornado education and information dissemination on university campuses is warranted. Faster personalization of risk, dispelling local myths, and educating those new to tornado-prone locations should be emphasized.
Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia
Authors: Qu Ying , Siggens Lee , Cordeddu Lina , Gaidzik Verena I. , Karlsson Kasper , Bullinger Lars , Döhner Konstanze , Ekwall Karl , Lehmann Sören , Lennartsson Andreas 
Published: December 2016

Key Points
DNA demethylation activates new and poised enhancers in AML that cause a leukemic transcriptome. Only a subset of DNA demethylated enhancers becomes activated. A specific additional activation step is required for enhancer activation.
Study protocol of the Asian XELIRI ProjecT (AXEPT): a multinational, randomized, non-inferiority, phase III trial of second-line chemotherapy for metastatic colorectal cancer, comparing the efficacy and safety of XELIRI with or without bevacizumab versus FOLFIRI with or without bevacizumab
Authors: Kotaka Masahito , Xu Ruihua , Muro Kei , Park Young Suk , Morita Satoshi , Iwasa Satoru , Uetake Hiroyuki , Nishina Tomohiro , Nozawa Hiroaki , Matsumoto Hiroshi , Yamazaki Kentaro , Han Sae-Won , Wang Wei , Ahn Joong Bae , Deng Yanhong , Cho Sang-Hee , Ba Yi , Lee Keun-Wook , Zhang Tao , Satoh Taroh , Buyse Marc E. , Ryoo Baek-Yeol , Shen Lin , Sakamoto Junichi , Kim Tae Won 
Published: December 2016

Abstract
Background
Capecitabine and irinotecan combination therapy (XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer (mCRC). Recently, in the Association of Medical Oncology of the German Cancer Society (AIO) 0604 trial, tri-weekly XELIRI plus bevacizumab, with reduced doses of irinotecan (200 mg/m2 on day 1) and capecitabine (1600 mg/m2 on days 1–14), repeated every 3 weeks, has shown favorable tolerability and efficacy which were comparable to those of capecitabine and oxaliplatin (XELOX) plus bevacizumab. The doses of capecitabine and irinotecan in the AIO trial are considered optimal. In a phase I/II study, XELIRI plus bevacizumab (BIX) as second-line chemotherapy was well tolerated and had promising efficacy in Japanese patients.

Methods
The Asian XELIRI ProjecT (AXEPT) is an East Asian collaborative, open-labelled, randomized, phase III clinical trial which was designed to demonstrate the non-inferiority of XELIRI with or without bevacizumab versus standard FOLFIRI (5-fluorouracil, leucovorin, and irinotecan combination) with or without bevacizumab as second-line chemotherapy for patients with mCRC. Patients with 20 years of age or older, histologically confirmed mCRC, Eastern Cooperative Oncology Group performance status 0–2, adequate organ function, and disease progression or intolerance of the first-line regimen will be eligible. Patients will be randomized (1:1) to receive standard FOLFIRI with or without bevacizumab (5 mg/kg on day 1), repeated every 2 weeks (FOLIRI arm) or XELIRI with or without bevacizumab (7.5 mg/kg on day 1), repeated every 3 weeks (XELIRI arm). A total of 464 events were estimated as necessary to show non-inferiority with a power of 80% at a one-sided α of 0.025, requiring a target sample size of 600 patients. The 95% confidence interval (CI) upper limit of the hazard ratio was pre-specified as less than 1.3.

Conclusion
The Asian XELIRI ProjecT is a multinational phase III trial being conducted to provide evidence for XELIRI with or without bevacizumab as a second-line treatment option of mCRC.
Trial registration ClinicalTrials.gov NCT01996306. UMIN000012263
NEW ADVANCES OF THE COMPATIBILITY INDEX “G” IN WEIGHTED ENVIRONMENTS
Authors: Garuti Claudio E. 
Published: December 2016

This article addresses the problem of measuring closeness in weighted environments (decision-making environments). This article is relevant because of the importance of having a dependable cardinal measure of distance in weighted environments. A weighted environment is a non-isotropic structure where the different directions (axes) may have different importance (weight) hence, privileged directions exist. In this kind of a structure, it would be very important to have a cardinal reliable index that is able to show how close or compatible the set of measures of one individual is with respect to the group or to any other, or how close one pattern of behavior is to another. A few common examples of the application of this are the interaction between actors in a decision making process (system values interaction), matching profiles, pattern recognition, and any situation where a process of measurement with qualitative variables is involved.
PRIORITIZATION OF PERFORMANCE MEASURES USING ANALYTIC HIERARCHY PROCESS
Authors: Vachnadze Revaz 
Published: December 2016

The purpose of this paper is to provide an integrated approach that prioritizes organizational performance measures and critical success factors towards the strategic objectives and initiatives of a firm. The Analytic Hierarchy Process (AHP) pair-wise comparisons and hierarchic composition technique is used to prioritize the key performance indicators (KPIs) and the key result indicators (KRIs) as well as the critical success factors (CSFs) of the organization within the frame of a single hierarchy. The new model presented in the paper will be more suitable for dealing with the problem than the others which are available. The application of the suggested model will enable staff to more closely align their daily activities to the strategic objectives of the firm. The suggested approach allows for a wide applicability to different types of organizations (business, nonprofit, public) and its use could significantly improve resource allocation and the overall performance in organizations.
Five Papers Presented at ISAHP 2014 are published in the International Journal of Production Economics
Authors: Karpak Birsen 
Published: December 2016

Eleven papers, out of 91 submitted, presented at the 13th International Symposium on the Analytic Hierarchy Process (ISAHP), held in Washington DC, USA, from June 29-July 2, 2014 were selected as candidate papers for the International Journal of Production Economics (IJPE) by the guest editors Drs. Birsen Karpak and Jennifer Shang. The following 5 out of 11 were able to go through the double blind review process handled by Dr. Peter Kelle, North-American Editor of IJPE, and are published.
Pogostost in značilnosti nasilja nad zdravstvenimi delavci na področju nujne medicinske pomoči in psihiatrije
Authors: Bojić Matej , Bole Urban , Bregar Branko 
Published: December 2016

Uvod: Nasilje pacientov nad zdravstvenimi delavci je ena izmed najbolj perečih težav, s katerimi se soočajo zdravstveni delavci. Namen raziskave je bil proučiti pojavnost ter oblike nasilnih vedenj, ki so jim izpostavljeni zdravstveni delavci na področju psihiatrije in nujne medicinske pomoči.
Metode: Raziskava je temeljila na neeksperimentalni kvantitativni metodi z nenaključnim priročnim vzorcem. Uporabljen je bil strukturirani vprašalnik Perception of Prevalence of Aggression Scale. Sodelovalo je 197 anketirancev. Raziskava je potekala od junija do oktobra 2015. Podatki so bili obdelani z deskriptivno statistiko, s faktorsko analizo – z metodo poševne rotacije OBLIMIN, z Mann-Whitneyevim testom in s Kruskal-Wallisovim testom.
Rezultati: Zaposleni v psihiatriji so pogosteje kot ostali anketiranci soočeni z manj ogrožajočim vedenjem (U = 2092,00, p = 0,008) in ogrožajočim vedenjem (U = 1685,50, p = 0,000). Anketirani z nižjo izobrazbo in zaposleni v izmenah so tisti, ki so nasilju bolj izpostavljeni. Ženske so v primerjavi z moškimi pogosteje soočene s spolnim nasilnim vedenjem (U = 3962,00, p = 0,033). Za obvladovanje nasilnega vedenja so anketirani nezadostno usposobljeni (x = 2,8, s = 1,186).
Diskusija in zaključek: Zaposleni v psihiatričnih bolnišnicah in enotah nujne medicinske pomoči se v raziskavi pogosto srečujejo z nasiljem. Potrebne bi bile raziskave, ki bi proučile povezanost usposabljanja s področja obvladovanja nasilnega vedenja pacientov na pojavnost nasilja nad zdravstvenimi delavci.
Agility, acceleration, speed and maximum speed relationship with age factor in soccer players<p>Futbolcularda yaşa bağlı çeviklik, ivmelenme, sürat ve maksimum sürat ilişkisi
Authors: Sever Ozan , Arslanoğlu Erkal 
Published: December 2016

The aim of study was to investigate age-related agility, acceleration, speed and maximum speed relationships in soccer players. Study consisted of 125 young football players aged between 14 and 18 from Karabükspor youth and reserve team who were measured for 30m speed,10m acceleration, 20m maximum speed, and T-Agility tests. The test values of players decreased with age as expected. All performance tests correlated significantly but coefficients of determination (r2) between agility test and all other tests were low. Acceleration and other tests except 30m speed also were low. There were no differences in age groups in terms of correlation between tests. Because of low coefficients of determination, it could be said that maximal speed, acceleration, agility were correlated by chance and were different components of physical performance so different training sessions should be planned for each physical abilities. ÖzetÇalışmada futbolcuların sürat, çeviklik, ivmelenme ve maksimum sürat becerilerinin yaşa bağlı değişimi ve birbirleri ile ilişkisi araştırılmıştır. Karabükspor altyapısı, A2 takımında 14-18 yaş aralığındaki 125 sporcu katılmıştır. Sporcuların 10m ivmelenme, 30m sürat ve T-Çeviklik ve 20 m maksimum sürat ölçümleri yapılmıştır. İstatistiksel analiz SPSS 19 programında yapılıp, 0,05 anlamlılık değeri olarak kabul edilmiştir. Sporcuların, çeviklik, ivmelenme, sürat ve maksimum sürat ölçüm süreleri yaş ile birlikte düşüş göstermektedir. En belirgin düşüş çeviklik testinde ortaya çıkmıştır. Tüm ölçümler arasında pozitif doğrusal ilişki vardır. Bu ilişki yaş faktörü ile incelendiğinde anlamlılık devam etmiştir. Fakat açıklayıcılık katsayılarına(r2) bakıldığında çeviklik ile diğer tüm ölçümler, ivmelenme ile 30 metre sürat süresi hariç tüm ölçümlerde düşük ilişki söz konusudur. Yaşa bağlı değişimde çevikliğin, doğrusal koşulara göre daha belirgin geliştiği ortaya çıkmıştır. Açıklayıcılık katsayısının düşük bulunması futbolcuların çeviklik, ivmelenme, sürat becerilerinin birbirleri ile güçlü ilişkisinin olmadığını göstermektedir. Bu fiziksel becerilerin birbirlerinden ayrı özellikler olduğu, antrenman planlamalarının bu beceriler ayrı ele alınarak yapılmasının faydalı olacağı düşünülmektedir.
KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABABReceptor-Induced K+Currents
Authors: Fritzius Thorsten , Turecek Rostislav , Seddik Riad , Kobayashi Hiroyuki , Tiao Jim , Rem Pascal D. , Metz Michaela , Kralikova Michaela , Bouvier Michel , Gassmann Martin , Bettler Bernhard 
Published: December 2016

GABABreceptors are the G-protein coupled receptors for the main inhibitory neurotransmitter in the brain, GABA. GABABreceptors were shown to associate with homo-oligomers of auxiliary KCTD8, KCTD12, KCTD12b, and KCTD16 subunits (named after their T1 K+-channel tetramerization domain) that regulate G-protein signaling of the receptor. Here we provide evidence that GABABreceptors also associate with hetero-oligomers of KCTD subunits. Coimmunoprecipitation experiments indicate that two-thirds of the KCTD16 proteins in the hippocampus of adult mice associate with KCTD12. We show that the KCTD proteins hetero-oligomerize through self-interacting T1 and H1 homology domains. Bioluminescence resonance energy transfer measurements in live cells reveal that KCTD12/KCTD16 hetero-oligomers associate with both the receptor and the G-protein. Electrophysiological experiments demonstrate that KCTD12/KCTD16 hetero-oligomers impart unique kinetic properties on G-protein-activated Kir3 currents. During prolonged receptor activation (one min) KCTD12/KCTD16 hetero-oligomers produce moderately desensitizing fast deactivating K+currents, whereas KCTD12 and KCTD16 homo-oligomers produce strongly desensitizing fast deactivating currents and nondesensitizing slowly deactivating currents, respectively. During short activation (2 s) KCTD12/KCTD16 hetero-oligomers produce nondesensitizing slowly deactivating currents. Electrophysiological recordings from hippocampal neurons of KCTD knock-out mice are consistent with these findings and indicate that KCTD12/KCTD16 hetero-oligomers increase the duration of slow IPSCs. In summary, our data demonstrate that simultaneous assembly of distinct KCTDs at the receptor increases the molecular and functional repertoire of native GABABreceptors and modulates physiologically induced K+current responses in the hippocampus.SIGNIFICANCE STATEMENTThe KCTD proteins 8, 12, and 16 are auxiliary subunits of GABABreceptors that differentially regulate G-protein signaling of the receptor. The KCTD proteins are generally assumed to function as homo-oligomers. Here we show that the KCTD proteins also assemble hetero-oligomers in all possible dual combinations. Experiments in live cells demonstrate that KCTD hetero-oligomers form at least tetramers and that these tetramers directly interact with the receptor and the G-protein. KCTD12/KCTD16 hetero-oligomers impart unique kinetic properties to GABABreceptor-induced Kir3 currents in heterologous cells. KCTD12/KCTD16 hetero-oligomers are abundant in the hippocampus, where they prolong the duration of slow IPSCs in pyramidal cells. Our data therefore support that KCTD hetero-oligomers modulate physiologically induced K+current responses in the brain.
The dilemma of scaling up local food initiatives: Is social infrastructure the essential ingredient?
Authors: Connelly Sean , Beckie Mary 
Published: December 2016

The purpose of this paper is to reflect on and compare two responses to the challenge of scaling up local food initiatives. Comparative case studies of the Good Food Box in the City of Edmonton and the Rimbey farmers’ market are used to examine the different strategies used to scale up their impacts as a means of providing a meaningful alternative to the status quo. Our findings suggest that investments in social infrastructure are crucial for maintaining the values and integrity of local food initiatives and also to highlight the challenges of doing so while in competition with the mainstream food system. Our research identifies how social infrastructure investments for local food initiatives can support radical and strategic incremental changes by managing the risk associated with transformative local food activities and provides opportunities for a reflexive approach to scale by identifying the levers and catalysts for broader change to ensure that investments in food system infrastructure are not made merely for the sake of scaling-up. Social infrastructure is identified as critical for building support for, and attention to, opportunities to scale out and develop connections, networks and partnerships for change beyond food.
Getting to the core of the matter: The rise and fall of the Nova Scotia apple industry, 1862-1980
Authors: Roberts-Stahlbrand Anika 
Published: December 2016

This article will apply food regime theory to an examination of the rise and fall of the apple industry in Nova Scotia between 1862 and 1980. From the 1860s until World War II, apples were a booming cross-Atlantic export business that continued the colonial bonds to Britain. But after the war, Britain developed its own domestic apple industry, and Nova Scotia apples failed to capture a loyal and secure market based on taste or quality. This led to the decline of the industry by the 1980s. Since that time, a new local apple industry based on taste and craft processing has arisen in Nova Scotia. This article affirms the broad historical analysis of food regime theory, while drawing attention to the need for an ecological enhancement of the theory.