bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Rapid Access to 3‐Aminoindazoles from Tertiary Amides.
Authors: Cyr Patrick , Regnier Sophie , Bechara William S. , Charette Andre B. 
Published: December 2015

AbstractBenzamides [e.g. (I)] react with nucleophilic hydrazides (e.g. [II]) to give aminohydrazones [e.g. (III)], which undergo Pd‐catalyzed C—H amination to afford aminoindazoles [e.g. (IV)].
ChemInform Abstract: A Convenient Approach to CF3‐Containing N‐Heterocycles Based on 2‐Methoxy‐2‐methyl‐5‐(trifluoromethyl)furan‐3(2H)‐one.
Authors: Bazhin Denis N. , Kudyakova Yulia S. , Roeschenthaler Gerd‐Volker , Burgart Yanina V. , Slepukhin Pavel A. , Isenov Maksim L. , Saloutin Victor I. , Charushin Valery N. 
Published: December 2015

AbstractNew synthetic routes to trifluoromethylated N‐heterocycles based on condensations of the title furanone with bifunctional N‐nucleophiles are presented.
ChemInform Abstract: Iodine Catalyzed Intramolecular C(sp3)—H Functionalization: Synthesis of 2,5‐Disubstituted Oxazoles from N‐Arylethylamides.
Authors: Samanta Supravat , Donthiri Ramachandra Reddy , Dinda Milan , Adimurthy Subbarayappa 
Published: December 2015

AbstractA wide range of the title oxazoles are obtained with good functional group tolerance using tBuOOH as oxidant under metal‐free conditions.
ChemInform Abstract: Synthesis of 2‐(Benzylthio)‐4‐(trifluoromethyl)thiazole‐5‐carboxylates Using S‐Benzylisothiouronium Halides as Thiol Equivalents.
Authors: Hickey Shane M. , White Jonathan M. , Pfeffer Frederick M. , Ashton Trent D. 
Published: December 2015

AbstractS‐Benzylisothiouronium halides (II) obtained by reaction of thiourea and benzyl halides are used as odorless, stable thiol equivalents in the synthesis of 2‐benzylthio‐derivatives of type (III).
ChemInform Abstract: Synthesis of Trifluoromethylated Tetrahydrochromeno[2,3‐c]pyrazol‐5(1H)‐ones via a One‐Pot Multicomponent Reaction in the Presence of 4‐Toluenesulfonic Acid.
Authors: Wang Xu , Kang Zhangping , Yang Xuyang , Yang Yang , Zhang Min , Song Liping , Deng Hongmei 
Published: December 2015

AbstractThe one‐pot three component reaction starts from dimedone or cyclohexane‐1,3‐dione, 2‐aryl‐5‐(trifluoromethyl)‐2,4‐dihydro‐3H‐pyrazol‐3‐ones and aromatic aldehydes, and tolerates neither aromatic aldehydes with strongly electron‐withdrawing groups nor aliphatic aldehydes.
ChemInform Abstract: Domino Prins Cyclization of Enynols: Stereoselective Synthesis of Bicyclic Vinyl Fluorides.
Authors: Venkateswarlu Anipireddy , Kanakaraju Marumudi. , Kunwar Ajit C. , Rami Reddy Yellala V. , Reddy Basi V. S. 
Published: December 2015

AbstractIsochromene derivatives are obtained from enynols and various aldehydes by a sequential Prins/alkynylation/fluorination domino process using stoichiometric amounts of AgSbF6.
ChemInform Abstract: Regioselective Synthesis of 6‐Vinyl‐3,6‐dihydropyridine‐2(1H)‐ones Through Simple Addition of a Vinylmagnesium “Ate” Complex to 2‐Pyridones.
Authors: Sosnicki Jacek G. , Dzitkowski Przemyslaw , Struk Lukasz 
Published: December 2015

AbstractLithium vinyldimethylmagnesate can be formed directly by mixing of vinylMgCl and MeLi.
ChemInform Abstract: Synthesis of Enantiopure 3‐Hydroxypiperidines from Sulfinyl Dienyl Amines by Diastereoselective Intramolecular Cyclization and [2,3]‐Sigmatropic Rearrangement.
Authors: Simal Carmen , Bates Robert H. , Urena Mercedes , Gimenez Irene , Koutsou Christina , Infantes Lourdes , Fernandez de la Pradilla Roberto , Viso Alma 
Published: December 2015

AbstractA wide range of tetrahydropyridin‐3‐ols is prepared by a general protocol starting from stereodefined 4‐sulfinyl dienyl amine derivatives.
ChemInform Abstract: Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel‐Catalyzed Denitrogenative Transannulation.
Authors: Fang Zhi‐Jia , Zheng Sheng‐Cai , Guo Zhen , Guo Jing‐Yao , Tan Bin , Liu Xin‐Yuan 
Published: December 2015

AbstractTreatment of various benzotriazines with internal alkynes under conditions A) provides isoquinolines with an (R)‐axial chirality.
ChemInform Abstract: DBU‐Promoted Cyclization of Vinyl Isocyanides with Ethers via the Functionalization of a C(sp3)—H Bond for the Synthesis of Isoquinolines.
Authors: Qian Ping , Du Bingnan , Zhou Jie , Mei Haibo , Han Jianlin , Pan Yi 
Published: December 2015

AbstractMultifunctionalized isoquinolines are obtained from readily available starting materials by a cascade base‐promoted radical cyclization and functionalization of aromatic vinyl isocyanates with cyclic ethers or thioether under simple conditions without use of any metal or photoredox catalyst.
ChemInform Abstract: Catalyst Controlled Divergent C4/C8 Site‐Selective C—H Arylation of Isoquinolones.
Authors: Lee Soyoung , Mah Shinmee , Hong Sungwoo 
Published: December 2015

AbstractThe Pd‐catalyzed arylation of isoquinolones (I) with aryliodonium salts leads to 4‐arylisoquinolones (III), whilst an Ir‐catalyzed reaction affords 8‐arylisoquinolones (V).
ChemInform Abstract: Copper‐Catalyzed Oxidative C‐H Amination: Synthesis of Imidazo[1,2‐a]‐N‐Heterocycles from N‐Heteroaryl Enaminones.
Authors: Reddy K. Ranjith , Reddy A. Siva , Shankar Ravi , Kant Rajni , Das Parthasarathi 
Published: December 2015

AbstractUnder ligand‐ and base‐free conditions imidazole‐containing heterocycles are formed in the presence of copper(I) salts.
ChemInform Abstract: Iron‐Catalyzed Kumada Cross‐Coupling Reactions of Pyrimidin‐2‐yl Phosphates: An Efficient Approach to C2‐Functionalized Pyrimidines.
Authors: Xing Ting , Zhang Zhang , Da Yu‐Xia , Quan Zheng‐Jun , Wang Xi‐Cun 
Published: December 2015

AbstractPyrimidine‐ and pyridine phosphates react with alkyl and aryl Grignard reagents in the presence of Fe(acac)3 under mild conditions to give the title compounds at room temperature within 15 minutes.
ChemInform Abstract: Highly Chemo‐ and Regioselective Allylic Substitution with Tautomerizable Heteroarenes.
Authors: Kumar Dinesh , Vemula Sandeep R. , Cook Gregory R. 
Published: December 2015

AbstractA wide range of allylating reagents, solvents, metal catalysts and ligands are tested for an optimized chemo‐ and regioselective allylation of N‐heterocycles.
ChemInform Abstract: A Rapid One‐Pot Ugi Reaction Based Route to Novel Imidazole‐Fused Benzodiazepinones.
Authors: Bhattacharya Debleena , Mitra Sudipta , Chattopadhyay Partha 
Published: December 2015

AbstractUgi three‐component reaction generates key intermediates for a Mumm rearrangement to form the title compounds (IV).
ChemInform Abstract: π‐Conjugated Bis(terpyridine)metal Complex Molecular Wires
Authors: Sakamoto Ryota , Wu Kuo‐Hui , Matsuoka Ryota , Maeda Hiroaki , Nishihara Hiroshi 
Published: December 2015

AbstractReview: [bottom‐up fabrication of linear and branched bis(terpyridine)metal complex wires on electrode surfaces, which feature distinct and characteristic electronic functionalities such as intra‐wire redox conduction and excellent long‐range electron transport ability; 84 refs.
Reinforced bending load‐stressed masonry – Suggestions for future designs / Bewehrtes biegedruckbeanspruchtes Mauerwerk – Vorschläge für zukünftige Bemessungen
Authors: Gunkler Erhard 
Published: December 2015

AbstractEuropean standardization bodies are currently working on the amendment to EN 1996‐1‐1, which will also affect the evaluation of reinforced masonry in Germany. For that reason, discussion suggestions are being made here for revisions to lay the groundwork for building materials evaluations and especially, evaluations of bending load‐stressed masonry walls or beams at their serviceability limit state (SLS) for load‐bearing capacities. Information already presented in E DIN 1053‐3:2008‐03 [N3] is being incorporated as well.Characteristic values for the compressive strength of the masonry parallel to the bed joints fk,∥ are essential for the design of reinforced masonry, although they are currently not included in national application documents for Germany. For the time being, they can be mathematically calculated using conversion factors for the characteristic compressive strength values vertical to the bed joints fk or by using the declared axial compressive strengths of the masonry units.The ultimate strains for masonry in general should be set consistently at ϵmu = ∣–0.002∣ as several masonry types do not exhibit higher compressive strain values. The use of steel strains higher than ϵsu = 0.005 does not change any measurement results. Varying stress‐strain curves of the constitutive equations on masonry under compressive strain (parabolic, parabolic‐rectangular, tension block) lead to differing values of recordable bending moments despite having the same mechanical reinforcement percentage at higher normal forces. Therefore, clear guidelines should be made for the type of applicable constitutive equation for masonry walls under compressive strain. With the introduction of a tension block, the number values of the reduction factors λ for the compression zone height x, which is dependent on limit strains, and where applicable, reduced compressive strength, need to be determined, as with reinforced concrete construction.A modification of the bending moment based on the second order theory according to [N4] is presented for the calculation of reinforced masonry walls in danger of buckling. The use of reduction factors for the load capacity of the masonry cross section, such as for unreinforced masonry, does not appear to be appropriate as buckling safety evidence because here, the design task is the determination of a required reinforcement cross section.
Redistribution of internal forces in the lateral bracing system / Schnittgrößenumlagerungen bei der Gebäudeaussteifung
Authors: Michel Kenan , Jäger Wolfram , Steinigen Frank 
Published: December 2015

AbstractThe lateral bracing system of a building should ensure the stability of the building, in terms of the usability and the total load capacity. The governing loads for the lateral bracing system are horizontal loads due to wind and earthquake. The horizontal loads are traditionally distributed to the bracing elements according to the uncracked elastic state dependent on the bending stiffness in the elastic (uncracked) state. This method does not allow consideration of non‐linear effects and load redistribution. Within the framework of the PRB Research Cooperation – Improving the Practical Use of Structural Design Standards through pre‐normative work – Subcontract 5: Masonry Construction, Subproject 3: “Large Shear Walls” [7], the cracked or plastic state can be taken into account through a displacement based approach. A matrix formulation for both the linear and cracked states has been derived and implemented.
The simplified calculation method of DIN EN 1996‐3 in practice / Das vereinfachte Bemessungsverfahren von DIN EN 1996‐3 in der Praxis
Authors: Schermer Detleff 
Published: December 2015

AbstractThe design and detailing of masonry buildings was usually undertaken in the past using the simplified procedure in Section 6 of DIN 1053‐1 (1996‐11). With the changeover to the new European code, a new procedure has been made available with the simplified calculation method of DIN EN 1996‐3, which promises similarly simple and safe handling for the user. The practical implementation of this new code has been underway for some time. The article investigates the standard design cases and explains the innovations and alterations compared to DIN 1053‐1.
Understanding controls on flow permanence in intermittent rivers to aid ecological research: integrating meteorology, geology and land cover
Authors: Costigan Katie H. , Jaeger Kristin L. , Goss Charles W. , Fritz Ken M. , Goebel P. Charles 
Published: December 2015

AbstractIntermittent rivers, those channels that periodically cease to flow, constitute over half of the total discharge of the global river network and will likely increase in their extent owing to climatic shifts and/or water resources development. Burgeoning research on intermittent river ecology has documented the importance of the meteorologic, geologic and land‐cover components of these ecosystems on structuring ecological communities, but mechanisms controlling flow permanence remain poorly understood. Here, we provide a framework of the meteorologic, geologic and land‐cover controls on intermittent streamflow across different spatio‐temporal scales and identify key research priorities to improve our understanding of intermittent systems so that we are better able to conserve, manage and protect them. Copyright © 2015 John Wiley & Sons, Ltd.
1H NMR spectroscopy and multivariate analysis as possible tool to assess cultivars, from specific geographical areas, in EVOOs
Authors: Girelli Chiara Roberta , Del Coco Laura , Fanizzi Francesco Paolo 
Published: December 2015

In this work, we tested a NMR‐based MVA method to assess the authenticity of EVOOs cultivar (from specific origin) declaration by using a total of over a 100 samples coming from different selected areas of Southern Italian Regions (Apulia and Calabria). We built a reference model, by performing unsupervised PCA and supervised PLS‐DA, OPLS‐DA analyses on the 1HNMR spectra of a 40 monovarietal EVOOs training set. These included 10 Coratina (the most popular Apulian cultivar) together with 10 Picholine, 10 Ogliarola Barese, and 10 Carolea samples (the most common Coratina bitterness smoothers cultivars used in Coratina‐based blends). The training set originated PLS‐DA reference model was profitably used to assess the class membership for a series of declared monocultivar EVOO samples and to obtain a clear indication for the composition of Coratina‐based blends. By using the same reference model we analyzed in blind a test set formed by 40 unknown samples coming from the same areas and we predicted their class or blend composition affinity (later confirmed by suppliers as Coratina‐ or Coratina‐based blends). This proposed method could be a simple and quick tool to assess, also for trading purpose, the cultivar (from given geographical areas) declaration of labeled EVOOs.Practical applications: EVOO is one of the most important element of the Mediterranean diet with its numerous health benefits due to the chemical composition (unsaturated fatty acids and minor components). For this high commercial value in the recent years, EVOO has been processed to adulteration process with seeds oils, refined pomace, and esterified oils with serious damage to its quality. In order to guarantee the quality of this important product, EU Regulation 182 of March 6, 2009, stated the obligatory labeling of EVOO samples with the geographical production area for all European countries. Surprisingly, this regulation lacks of an official methodology to assess the origin and the cultivar of EVOOs. A quick and reproducible method to check the label declaration of commercial EVOOs could be attractive for industry and ensure transparency for consumer choices.Work flow chart illustrating the procedures sequence to assess cultivars, from specific geographical areas, in EVOOs. A reference model is built and its prediction capability is tested with monovarietal and blend commercial extra virgin olive oil samples.
Impact of Ionomer Content on Proton Exchange Membrane Fuel Cell Performance
Authors: Afsahi F. , Mathieu‐Potvin F. , Kaliaguine S. 
Published: December 2015

AbstractThe effect of Nafion ionomer content on performance of a proton exchange membrane (PEM) fuel cell operated with home‐made anodic and cathodic electrodes fabricated from a novel metal organic framework (MOF) derived Pt‐based electrocatalyst was investigated via numerical simulation and experimental measurement. First, the parameter sensitivity analysis was performed to identify the most influential parameters of the model. Then, these parameters were calibrated for different fuel cell designs investigated in the current study by employing the corresponding experimental data. Afterwards, the calibrated model was used to examine the impact of Nafion content in the catalyst layer of home‐made electrodes. Finally, the qualitative trend predicted by this model was experimentally surveyed by varying the Nafion content between 10–50 wt.% in the catalyst layer of home‐made electrodes. At the anode side, the performance of home‐made electrode in a PEM fuel cell demonstrated small dependency on Nafion content. For the cathodic home‐made electrode, Nafion content was found to affect the PEM fuel cell performance more strongly. Although the model could correctly capture the impact of Nafion content on calculated polarization curves, the model predicted optimum values significantly deviate from the experimental results. This was related to the several simplifications made during model development.
Socio‐economic Inequality in the Use of Procedures and Mortality Among AMI Patients: Quantifying the Effects Along Different Paths
Authors: Hagen Terje P. , Häkkinen Unto , Iversen Tor , Klitkou Søren Toksvig , Moger Tron Anders ,   on behalf of the EuroHOPE study group
Published: December 2015

AbstractIt is not known whether inequality in access to cardiac procedures translates into inequality in mortality. In this paper, we use a path analysis model to quantify both the direct effect of socio‐economic status on mortality and the indirect effect of socio‐economic status on mortality as mediated by the provision of cardiac procedures. The study links microdata from the Finnish and Norwegian national patient registers describing treatment episodes with data from prescription registers, causes‐of‐death registers and registers covering education and income. We show that socio‐economic variables affect access to percutaneous coronary intervention in both countries, but that these effects are only moderate and that the indirect effects of the socio‐economic factors on mortality through access to percutaneous coronary intervention are minor. The direct effects of income and education on mortality are significantly larger. We conclude that the socio‐economic gradient in the use of percutaneous coronary intervention adds to socio‐economic differences in mortality to little or no extent. Copyright © 2015 John Wiley & Sons, Ltd.
Link adaptation in mobile satellite links: schemes for different degrees of CSI knowledge
Authors: Rico‐Alvariño Alberto , Arnau Jesus , Mosquera Carlos 
Published: December 2015

SummaryWe consider the problem of modulation and coding scheme selection in the return link of a mobile satellite system. We propose to use an affine combination of both open loop and closed loop signal quality indicators to perform this selection. The combination weights are dynamically adapted according to the acknowledgement/negative acknowledgement (ACK/NAK) exchange between both ends, without making any assumptions on the channel distribution; this adaptation procedure is obtained as a stochastic programming solution to an optimization problem. We further extend our analysis to the particular case of not having information on the channel state, exploiting only ACK/NAK exchange for the rate selection problem. Simulation results will show the good performance of the proposed affine‐combination method compared with previous algorithms, and its robustness to environment changes. Copyright © 2015 John Wiley & Sons, Ltd.
Security approach to controlling access to personal health records in healthcare service
Authors: Chen Tzer‐Long , Liao Yu‐Ting , Chang Yi‐Fan , Hwang Jen‐Hung 
Published: December 2015

AbstractThe changing information technology and the constant progress of medical technologies have gradually changed traditional paper‐based medical records into low‐cost electronic health records. The broad application of electronic health records allows a medical information exchange model being developed, called personal health records (PHR), which are the personal health medical information managed and maintained by the user. In consideration of PHR being a patient's health medical information, the privacy setting and the access authority have to be strictly controlled. In addition to providing users with reasonable access authorities, the PHR system has to avoid the illegal access of unauthorized single users or groups. The idea of public‐key cryptosystems and Lagrange interpolating polynomial is applied to construct a high‐security and efficient encryption scheme so that PHR users could execute the access system in a secure environment. Copyright © 2015 John Wiley & Sons, Ltd.
Neonatal mortality and outcome at the end of the first year of life in early onset urea cycle disorders—review and meta‐analysis of observational studies published over more than 35 years
Authors: Burgard Peter , Kölker Stefan , Haege Gisela , Lindner Martin , Hoffmann Georg F. 
Published: December 2015

AbstractBackgroundFor urea cycle disorders (UCD), proportions and mortality of early onset (EO) patients, as well as outcome at one year of life show large variability. We aimed to integrate available evidence to create benchmarks for new diagnostic and therapeutic strategies.MethodsMedline search for reports published between 1978 and Dec 22, 2014 was completed by hand search. Random effects meta‐analysis was done for four UCDs, deficiency of carbamylphosphate synthetase 1 (CPS1D), male/female ornithine transcarbamylase (OTCDm/f), argininosuccinate synthetase (ASSD) and lyase (ASLD). Effects of publication year and geographic area were analysed by meta‐regression.ResultsTwenty‐four publications report onset time (n = 1542 patients), survival of EO (n = 665 patients) and outcome at one year of life (n = 172 patients). Proportions for EO manifestation (95 % confidence interval) were: CPS1D = 0.75 (0.61;0.88); OTCDm = 0.52 (0.39;0.65); OTCDf = 0.07 (0.03;0.11); ASSD = 0.65 (0.57;0.73); ASLD = 0.60 (0.44;0.77); for surviving EO patients: CPS1D = 0.64 (0.50;0.79); OTCDm = 0.40 (0.16;0.64); OTCDf = 0.57 (0.29;0.85); ASSD = 0.67 (0.48;0.86); ASLD = 0.81 (0.68;0.94); and for normal outcome at one year for survivors: CPS1D = 0.20 (0.07;0.38); OTCDm = 0.15 (0.00;0.39); OTCDf no data; ASSD = 0.36 (0.13;0.60); ASLD = 0.36 (0.17;0.58). Between study variation was large. Year of publication had no effect. Studies from Europe showed lower survival rates than those from Japan or USA.ConclusionsUCDs, except for OTCDf, have high risks of EO disease manifestation and, except for ASLD, of neonatal death. No improvement of survival was observed over more than three decades. Geographic variation remains to be explained. This comprehensive description of the natural history of EO UCDs should be considered by scientists, clinicians, health policy makers and guideline developers.
Mikrozephalie bei psychomotorischen Entwicklungsstörungen und geistiger Behinderung
Authors: Zweier Christiane 
Published: December 2015

Zusammenfassung
Eine geistige Behinderung kommt bei ca. 2–3 % der Bevölkerung vor. Sowohl die klinischen Erscheinungsbilder als auch die genetischen Ursachen sind extrem heterogen. Es können sowohl chromosomale als auch monogene Veränderungen ursächlich sein. Eine Mikrozephalie ist ein häufiges Symptom bei psychomotorischen Entwicklungsstörungen und geistiger Behinderung, was auf überlappende Pathomechanismen hindeutet. Etwa 23 % der bekannten, mit geistiger Behinderung assoziierten Gene sind auch mit Mikrozephalie assoziiert. Weitere häufige Komorbiditäten sind Krampfanfälle, Kleinwuchs oder Fehlbildungen. In einer Kohorte von über 700 Patienten mit psychomotorischer Entwicklungsstörung, die in der genetischen Sprechstunde des Humangenetischen Instituts in Erlangen gesehen wurden, waren 22,5 % auch mikrozephal. Dabei korrelierte die Schwere der Mikrozephalie mit der Schwere der kognitiven Einschränkung und dem Auftreten von Krampfanfällen.
In dieser Übersichtsarbeit werden genetische Ursachen für psychomotorische Entwicklungsstörungen mit Mikrozephalie sowie die Häufigkeit einer Mikrozephalie in einer Kohorte von Patienten mit ungeklärter Entwicklungsstörung und ihre Bedeutung bei der Diagnosefindung bei geistiger Behinderung diskutiert.