bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping variants in HTLV‐1 genome to analyze their impacts on the HAM/TSP development: A systematic review
Authors: Lima Ana Carolina Marinho Monteiro , Silva Dhara Isabella Barreto de Souza , Campos Raissa Frazão , de Oliveira Andrade Felipe , Nascimento Jéssica Oliveira de Souza , Santana Carolina Souza , Barreto Laura Nascimento , Cucco Marina Silveira , Borba Melina Mosquero Navarro , Costa Davi Tanajura , Khouri Ricardo , Barreto Fernanda Khouri , Santos Luciane Amorim 
Published: September 2024

AbstractThe reasons that lead some individuals living with the Human T Lymphotropic Virus 1 (HTLV‐1) to develop HAM/TSP are still unclear. To better understand the viral genetic factors that may be associated with the development of HAM/TSP, this study aims to evaluate the impact of HTLV‐1 genome mutations on the development of this disease through a systematic review. This review followed the PRISMA guidelines and was registered in the PROSPERO database. The search for articles was performed in PMC, PubMed, Lilacs, SciELO, and Embase databases using the following search descriptors: HTLV‐1, HAM/TSP, mutation, polymorphism, genetic variation, and sequenc*. From the 1,929 articles found in the search, 20 were selected according to the pre‐defined inclusion and exclusion criteria. A total of 619 HAM/TSP cases were compared with 555 AC controls. The mutations possibly related to the disease progression were detected in hbz (R119Q), tax (A7959V), ORF‐I (R88K, P86S, S69G, P45L, L40F, C39R, CR9Y), and gp46 (V247I, N93D, S72G) genetic regions. The data collected and analyzed here indicate that mutations in the HTLV‐1 genome could play an important role in the chronic inflammatory state and may be related to the development of HAM/TSP.
Comparative immune profiling in survivors of the 2023 Nipah outbreak in Kerala state, India
Authors: Sahay Rima R. , Palav Harsha C. , Shete Anita M. , Patil Deepak Y. , Mohandas Sreelekshmy , Radhakrishnan Chandni , Shihabudheen P. , Kumar Anoop , Moorkoth Anitha Puduvail , Mohite Nandan , Gurav Pranay , Pullor Niyas K. , Jain Rajlaxmi , Joshi Yash , Ramakrishnan Lathika Velichapat , Gupta Nivedita , Patel Vainav , Yadav Pragya D. 
Published: September 2024

AbstractImmune profiling of Nipah virus (NiV) infection survivors is essential for advancing our understanding of NiV pathogenesis, improving diagnostic and therapeutic strategies, and guiding public health efforts to prevent future outbreaks. There is currently limited data available on the immune response to NiV infection. We aimed to elucidate the specific immune mechanisms involved in protection against NiV infection by analyzing the immune profiles of survivors of the Nipah outbreak in Kerala, India 2023. Immune cell populations were quantified and compared between survivors (up to 4 months post onset day of illness) and healthy controls. Statistical analysis was performed to explore associations between immune profiles and clinical outcomes. Immune signatures common to all three cases were: a heretofore undescribed persistent lymphopenia including the CD4+ Treg compartment with the relative expansion of memory Tregs; trends indicative of global leukopenic modulation were observed in monocytes and granulocytes including an expansion of putatively immunosuppressive low‐density granulocytes described recently in the context of severe COVID‐19; altered mucosal homing with respect to integrin beta‐7 (ITGB7) expressing subsets; increased mobilization of activated T‐cells (CD4+ and CD8+) and plasmablasts in the early phase of infection. Comparative analysis based on clinical presentation and outcome yielded lower initial viremia, increased activated T‐cell responses, expanded plasmablasts, and restoration of ITGB7 expressing CD8+ T‐cells as possible protective signatures. This longitudinal study delineates putative protective signatures associated with milder NiV disease. It emphasizes the need for the development of immunotherapeutic interventions such as monoclonal antibodies to blunt early viremia and ameliorate pathogenesis.
Glymphatic System Impairment in the Advanced Stage of Moyamoya Disease
Authors: Jin Lingji , Hu Junwen , Han Guangxu , Li Yin , Zhu Jun , Zhu Yuhan , He Xuchao , Xu Duo , Zheng Leilei , Bai Ruiliang , Wang Lin 
Published: September 2024

ABSTRACTAssessing the glymphatic system activity using diffusion tensor imaging analysis along with the perivascular space (DTI‐ALPS) may be helpful to understand the pathophysiology of moyamoya disease (MMD). 63 adult patients with MMD and 20 healthy controls (HCs) were included for T1‐weighted images, T2‐FLAIR, pseudocontinuous arterial spin labeling, and DTI. 60 patients had digital subtraction angiography more than 6 months after combined revascularization. The Suzuki stage, postoperative Matsushima grade, periventricular anastomoses (PA), enlarged perivascular spaces (EPVS), deep and subcortical white matter hyperintensities (DSWMH), DTI‐ALPS, cerebral blood flow (CBF), and cognitive scales of MMD patients were assessed. MMD patients were divided into early and advanced stage based on the Suzuki stage. We detected lower DTI‐ALPS in patients with advanced stage relative to HCs (p = 0.046) and patients with early stage (p = 0.004), hemorrhagic MMD compared with ischemic MMD (p = 0.048), and PA Grade 2 compared with Grade 0 (p = 0.010). DTI‐ALPS was correlated with the EPVS in basal ganglia (r = −0.686, p < 0.001), Suzuki stage (r = −0.465, p < 0.001), DSWMH (r = −0.423, p = 0.001), and global CBF (r = 0.300, p = 0.017) and cognitive scores (r = 0.343, p = 0.018). The DTI‐ALPS of patients with good postoperative collateral formation was higher compared to those with poor postoperative collateral formation (p = 0.038). In conclusion, the glymphatic system was impaired in advanced MMD patients and may affected cognitive function and postoperative neoangiogenesis.
Transformational Creativity, Care, and the Common Good: Toward a Refined Definition?
Authors: Verger Nicolas B. 
Published: September 2024

ABSTRACTThe concept of transformational creativity has been widely embraced as a desired shift in creativity research. Transformational creativity emphasizes the development of creativity in service to the common good. However, to date, what precisely constitutes this “common good” for researchers of transformational creativity remains unclear. As evidenced by the recent Handbook of Transformational Creativity, the term “common good” has been deployed on numerous occasions without any definition or rationalization of its meaning. The aim of this article was therefore to delineate what may constitute a common good which is worth contributing to. Motivated by transdisciplinary outlooks, it explores the concept of the common good through the lenses of human needs, degrowth, and the ethics of care. This article redefines transformational creativity as the creation of new ideas, artifacts, or practices that promote the common good by fostering caring, needs‐responsive relationships and enabling communities to collectively contribute to their well‐being and support a sustainable, ecologically nurturing, and preserving livelihood.
Sonographic Characteristics of ≥7 mm Gallbladder Polyps
Authors: Chai Jessie L. , Baranov Esther , Licaros Andro Reginald , Frates Mary C. 
Published: September 2024

ObjectivesTo describe the sonographic characteristics of gallbladder polyps measuring ≥7 mm focusing on echogenicity, correlate with surgical pathology when available, and assess stability in size over time.MethodsThis retrospective study used a natural language processing application to screen ultrasound (US) reports between January 1, 2012, and December 31, 2020, that contained the words “gallbladder polyp” or “polyps.” Reports were reviewed to identify polyps ≥7 mm. The most hyperechoic components of the polyps were compared to the adjacent inner wall of the gallbladder and categorized as more echogenic, isoechoic, and less echogenic. Other sonographic characteristics such as heterogeneity, sessile configuration, vascularity, multiplicity, presence of gallstones, and wall thickening were recorded. Surgical pathology reports were reviewed when available. Polyps in nonsurgical patients with ≥48‐month US follow‐up and ≤1 mm/year growth rate were characterized as benign. Clinical outcomes were followed until December 31, 2023.ResultsReview of 4897 reports yielded 550 reports in 450 patients with polyps ≥7 mm. Surgical pathology reports were available in 22.0% (99/450) of patients; 96 (97%) had non‐neoplastic etiologies and 3 (3.0%) neoplastic. There were no malignancies. All of the neoplastic polyps and 56.1% (87/155) of non‐neoplastic polyps had components more echogenic than the adjacent inner wall. There were no deaths related to the polyps.ConclusionsThe vast majority of gallbladder polyps are benign. In our large series of gallbladder polyps, we found that increased echogenicity is a nonspecific feature, found in slightly more than half of benign but also in all neoplastic polyps. Our findings support current Society of Radiologists in Ultrasound consensus guidelines.
Vocal Fold Pseudocysts: Are Unilateral and Bilateral Lesions Distinct Entities?
Authors: Clark Christine M. , Kim Yeo Eun , Sulica Lucian 
Published: September 2024

BackgroundUnilateral vocal fold pseudocysts have been hypothesized to result from vocal fold paresis, but no explanation has been proposed for bilateral lesions. This study compares patients with unilateral to those with bilateral pseudocysts for insights into pathogenesis.MethodsAdults with unilateral and bilateral pseudocysts evaluated between 2018 and 2023 were retrospectively studied. Patient demographics, laryngeal stroboscopic findings, management strategies employed, and treatment outcomes were recorded. Fisher's exact and student's t‐tests were performed to assess unilateral and bilateral cohorts for differences.ResultsOne hundred ninety‐six patients (109 with bilateral and 87 with unilateral pseudocysts) were studied. The average age was 29 years (bilateral: 29 years, unilateral: 30 years; p = 0.3846). The groups differed with respect to sex (172 females: 105 bilateral, 67 unilateral; 24 males: 4 bilateral, 20 unilateral; p < 0.0001) and clinical diagnosis of paresis (bilateral: 13.8%, unilateral: 34.5%; p = 0.0010). Treatment was similar between cohorts for rates of voice therapy (bilateral: 67.0%, unilateral 63.2%; p = 0.6511) and surgery (bilateral: 12.8%, unilateral 17.2%; p = 0.4228). There were a total of six recurrences (bilateral: 2, unilateral: 4; p = 0.3898).ConclusionsBilateral pseudocysts occur almost exclusively in women and with a relative absence of paresis. Unilateral pseudocysts are more likely to occur in the presence of paresis and in a significantly higher proportion of men. This suggests that unilateral and bilateral disease evolve in different clinical conditions, although they may share glottic insufficiency as a predisposing factor.Level of EvidenceIII Laryngoscope, 2024
In Vivo Histological Study Evaluating Non‐Ablative Fractional 1940‐nm Laser
Authors: Schallen Konika Patel , Seder Madelyn , Jorgenson Michael , Schomacker Kevin , Bhawan Jag 
Published: September 2024

ABSTRACTObjectivesNon‐ablative fractional lasers (NAFL) have increased in demand compared to ablative laser treatments as they provide lesser down time, fewer side‐effects, and are safer to use. Non‐ablative fractional treatment with lasers ranging from 1320 to 1927‐nm have been shown to be safe and effective for skin resurfacing procedures. The objective of this study is to investigate healing of the 1940‐nm NAFL‐induced microthermal treatment zones (MTZs) in human skin from a histologic perspective.MethodsThree subjects received 1940‐nm NAFL treatment to test areas on the abdomen at various timepoints during the study. The minimum 5 mJ/MTZ and maximum 20 mJ/MTZ energy settings were used at 20% coverage. Biopsies were taken coinciding with immediately posttreatment, 1, 3, 7 days, and 6 weeks posttreatment. Blinded analysis of hematoxylin and eosin stained slides was performed to measure the width and depth of the MTZs and evaluate the inflammatory and healing response of the skin over time (immediately to 6 weeks posttreatment). Safety was evaluated by assessing local skin responses and adverse events immediately after treatment and at all study visits.ResultsHistological analysis of tissue following NAFL 1940‐nm treatments showed mild early inflammatory response (presence of lymphotic infiltrate) in some test areas and zones of necrosis and coagulation having widths and depths (immediately–3 days posttreatment) that scaled with the 1940‐nm pulse energy. Signs of healing such as presence of dermal mucin, evidence of fibrosis, and absence of necrosis were observed long‐term (7 days to 6 weeks posttreatment). Evidence of the MTZ persisted beyond the 6‐week study and was predicted to last for 100 days. All local clinical skin responses healed within 6 weeks and were limited to mild, transient erythema and edema which resolved in less than 12–24 h following treatment. No serious adverse events occurred during the study.ConclusionsNAFL 1940‐nm treatments are safe for inducing small fractional coagulation and necrosis zones in abdominal skin. NAFL 1940‐nm laser creates fractional columns of injury with sufficient depth and coverage that suggest effective skin resurfacing, like other non‐ablative fractional lasers.
Nonconcentration phenomenon for one‐dimensional reaction–diffusion systems with mass dissipation
Authors: Yang Juan , Kostianko Anna , Sun Chunyou , Tang Bao Quoc , Zelik Sergey 
Published: September 2024

AbstractReaction–diffusion systems with mass dissipation are known to possess blow‐up solutions in high dimensions when the nonlinearities have super quadratic growth rates. In dimension 1, it has been shown recently that one can have global existence of bounded solutions if nonlinearities are at most cubic. For the cubic intermediate sum condition, that is, nonlinearities might have arbitrarily high growth rates, an additional entropy inequality had to be imposed. In this paper, we remove this extra entropy assumption completely and obtain global boundedness for reaction–diffusion systems with cubic intermediate sum condition. The novel idea is to show a nonconcentration phenomenon for mass dissipating systems, that is the mass dissipation implies a dissipation in a Morrey space for some . As far as we are concerned, it is the first time such a bound is derived for mass dissipating reaction–diffusion systems. The results are then applied to obtain global existence and boundedness of solutions to an oscillatory Belousov–Zhabotinsky system, which satisfies cubic intermediate sum condition but does not fulfill the entropy assumption. Extensions include global existence mass controlled systems with slightly super cubic intermediate sum condition.
Janus Structure Construction of Polyester‐Cotton Fabrics for Achieving Excellent Moisture, Moisture‐Permeability, and Antibacterial Capability
Authors: Shen Liwen , Wang Pei , Xiang Shuangfei , Zhao Shujun , Fu Feiya , Dong Qingqi , Liu Xiangdong 
Published: September 2024

AbstractIntegration of hydrophobic and antibacterial functionalities into polyester‐cotton blended (PTCO) textiles has attracted more attention but remains a challenge. Here, a Janus fabric with antibacterial effect, hydrophobicity, and enhanced moisture‐permeability is fabricated using a “mist polymerization” approach. The PET fibers in the PTCO fabric are amino‐functionalized through ammonolysis reactions of PET molecules with HDA, and mist treatments of poly lauryl methacrylate (PLMA) and poly(DMC‐co‐MA) (PDM) are applied on the two side surfaces of the PTCO‐HDA fabric, respectively. The resulting Janus fabric exhibits an antibacterial rate of 99.9% against both E. coli and S. aureus, along with a hydrophobic property on its single side (PTCO‐HDA@PLMA). Additionally, the establishment of a surface‐free energy gradient across the fabric confers superior moisture‐permeability to the Janus fabric, offering advantages in preserving textile comfort. Moreover, this approach does not significantly compromise the original fabric properties, such as mechanical strength, moisture permeability, and fabric softness. The proposed method offers a straightforward and scalable strategy for textile finishing, demonstrating great potential in expanding the application scope of PTCO fabrics, and it may hold a pivotal role in diverse applications, notably encompassing home textiles, wound dressings, and high‐performance sportswear.
Iltamiocel Autologous Cell Therapy for the Treatment of Female Stress Urinary Incontinence: A Double‐Blind, Randomized, Stratified, Placebo‐Controlled Trial
Authors: Kaufman Melissa R. , Goldman Howard B. , Chermansky Christopher J. , Dmochowski Roger , Kennelly Michael J. , Peters Kenneth M. , Quiroz Lieschen H. , Bennett Jason B. , Thomas Sherry , Marguet Charles G. , Benson Kevin D. , Lee Una J. , Sokol Eric R. , Wolter Christopher E. , Katz Daniel M. , Tarnay Christopher M. , Antosh Danielle , Heit Michael H. , Rehme Christian , Karram Mickey , Snyder Scott , Canestrari Emanuele , Jankowski Ron J. , Chancellor Michael B. 
Published: September 2024

ABSTRACTAimsThis study aimed to determine the efficacy and safety of iltamiocel investigational autologous muscle cell therapy in females with stress urinary incontinence (SUI).MethodsAdult females were randomized 2:1 to iltamiocel (150 × 106 cells) or placebo and stratified by severity and prior SUI surgery. The primary objective was efficacy based on the frequency of stress incontinence episodes (SIE) recorded in a 3‐day diary at 12 months posttreatment. After 12 months, placebo participants could elect to receive open‐label iltamiocel. Efficacy and safety analyses were performed using all patients as treated populations.ResultsThe study enrolled 311 patients, 297 were randomized to either iltamiocel (n = 199) or placebo (n = 98). Of the 295 participants that completed 12 months blinded follow‐up, the proportion achieving the primary endpoint of ≥ 50% SIE reduction was not statistically different between treatment groups (52% vs. 53.6%; p = 0.798). A significantly greater proportion of iltamiocel participants in the prior SUI surgery stratum group achieved ≥ 75% SIE reduction compared with placebo, (40% vs. 16%; p = 0.037). Treatment response was maintained at 24 months in 78.4% and 64.9% of iltamiocel participants who achieved ≥ 50% and ≥ 75% SIE reduction, respectively, at Month 12. Adverse events related to the treatment were reported in 19 (9.5%) iltamiocel participants and 6 (6.1%) placebo participants.ConclusionThe study did not meet its primary endpoint however, iltamiocel cell therapy is safe and may be ideally suited to female patients who have undergone prior surgery for SUI. Additional study in this group of patients with high unmet medical needs is warranted.Trial RegistrationClinicalTrials.gov identifier: NCT01893138; EudraCT number: 2014‐002919‐41.
Subtypes of Job Satisfaction and Health‐Related Quality of Life in Chinese Male Nurses: A Latent Profile Analysis
Authors: Kong Wenwen , Li Miao , Chen Xinxia , Feng Danjun 
Published: September 2024

ABSTRACTIn this cross‐sectional study, we aimed to identify subgroups of job satisfaction and health‐related quality of life (HRQoL) in Chinese male nurses and examine the factors associated with subgroup profiles. A convenience sample of 626 Chinese male nurses were enrolled from January to October 2021. Latent profile analysis was performed to identify profiles based on self‐esteem, psychological resilience, social support, neuroticism, perceived prejudice, occupational stress, job satisfaction, and HRQoL. Chi‐squared tests were used to examine predictors of profiles. Results indicated that a three‐profile model provided the best fit: low job satisfaction and health (9.90%), moderate job satisfaction and health (64.06%), and high job satisfaction and health (26.04%). The average number of monthly night shifts was negatively correlated with the male nurses' subgroups. Psychological resilience, social support, and neuroticism were the key factors associated with the HRQoL of male nurses, while perceived prejudice, occupational stress, and self‐esteem were the key factors associated with job satisfaction. Nurse administrators could improve their job satisfaction and health by reducing perceived prejudice, and job stress, increasing organizational support and resilience.
Medical Malpractice in Otolaryngology within the United States: A LexisNexis‐Based Demographic Analysis
Authors: Sharma Shiven , Edalati Shaun , Chung Tony , Wallace Nathan , Eloy Jean A. , Man Li‐Xing , Genden Eric M , Govindaraj Satish 
Published: September 2024

AbstractObjectiveOtolaryngologists are at a significantly greater risk of being sued than most other physicians. To date, there is a lack of studies characterizing trends in otolaryngology malpractice claims. To assess these trends and risk variables, this study examined malpractice claims against otolaryngologists.Study DesignRetrospective database review.SettingLexisNexis Jury Verdicts and Settlements.MethodsThe LexisNexis legal database was used to locate jury verdicts and settlements related to medical malpractice in otolaryngology, from 2018 to 2024. The study did not include any claims covered by the Social Security Disability Insurance, Workers' Compensation, Healthcare Law, or Criminal Law and Procedure categories. Temporal trends were evaluated, and logistic regression was used to identify independent risk factors.ResultsOut of 903 items, 79 reported malpractice cases were included (mean age 44.5; 60.3% female). The most sued subspecialty was head and neck oncology (32.5%). Negligence (93.7%) was the primary cause of action. Of cases sent to the jury, 87.7% of them resulted in a verdict in favor of the defendant. The mean plaintiff verdict payout was $7,432,508.06 and the mean identified settlement amount was $1,562,500.00. Physical injury (62.0%) was the highest type of harm. Regional analysis indicated a higher percentage of cases from New York favored the defendant (21.1% vs 13.6%; P = .034).ConclusionThis study highlights key trends in otolaryngology malpractice claims, emphasizing the prevalence in cases of head and neck surgery, primarily attributed to negligence. By identifying trends and risk factors, otolaryngologists can get a better understanding of the dynamics surrounding malpractice.
Empowering the digital learner: Exploring the relationship between teacher support, autonomy in technology, and self‐efficacy in Chinese vocational colleges
Authors: Wang Dan , Qiu Qian , Wang Lijuan , Jiang Yu , Ran Aihua 
Published: September 2024

AbstractIn Chinese vocational colleges, students often avoid classroom challenges and lack persistent academic engagement. This was perceived as a deficiency in self‐efficacy and a need for greater teacher–student engagement. The rapid advancement of information technology in educational contexts indicates that the dynamics among teacher support, technological autonomy, and self‐efficacy will become crucial for learning outcomes. Hence, this study explored the relationship between teacher support and student self‐efficacy, focusing on the mediating role of student autonomy in technology. A questionnaire survey administered to 606 first‐year students was analyzed using Pearson's correlation coefficient and Process V3.3. The results showed that teacher support and student self‐efficacy were moderately positively correlated (r = .464, p < .01). However, technological autonomy appeared to be significantly positively correlated with teacher support (r = .368, p < .01) and self‐efficacy (r = .515, p < .01). The results highlight the instrumental role of teacher support in enhancing student self‐efficacy and the important role of technological autonomy as a mediating factor. These findings confirm the need for continuing social support and interactive roles between teachers and students to enhance student self‐efficacy in higher education. Furthermore, technology should be leveraged to foster a conducive learning environment.