bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einfluss der Fettleber auf den Glukosestoffwechsel nicht unterschätzen
Authors: Stefan Norbert , Pfeiffer Andreas F , Birkenfeld Andreas , Herzig Stephan , Schürmann Annette , Tschöp Matthias , Häring Hans-Ulrich , Roden Michael 
Published: July 2017

ZUSAMMENFASSUNGDie nicht alkoholische Fettleber gilt in Europa und den USA als die häufigste Ursache für chronische Lebererkrankungen. Experten gehen davon aus, dass in Europa bis zu 30 % der Bevölkerung davon betroffen sind. Zu viel Fett in der Leber führt dabei nicht nur zu einer chronischen Erkankung der Leber, es hat auch einen negativen Einfluss auf den Zuckerstoffwechsel und führt beispielsweise zur Entwicklung eines Typ-2-Diabetes. Aus diesem Grund rücken neue Möglichkeiten zur Therapie der Fettleber immer mehr in den Fokus. Dabei werden sowohl Ernährungsumstellungen als auch medikamentöse Ansätze berücksichtigt. Um den Zusammenhang zwischen Leber und Typ-2-Diabetes noch zielgerichteter zu untersuchen, baut das Deutsche Zentrum für Diabetesforschung einen Forschungsschwerpunkt zum Thema Fettleber auf.
Genetic Alterations in Pendrin (SLC26A4) Gene in Adult Hypothyroid Patients
Authors: Mukherjee Sourav , Guha Manalee , Adhikary Bidisha , Bankura Biswabandhu , Mitra Pubali , Chowdhury Subhankar , Das Madhusudan 
Published: July 2017

AbstractCurrent study was aimed to screen the SLC26A4 gene in 127 nonautoimmune and noncongenital hypothyroid patients, who were under optimal iodine nutrition and devoid of any characteristics of Pendred syndrome from eastern part of Indian population. 8 single nucleotide variants/mutations were identified in heterozygous state in 20% patient population, which include 1 novel nonsynonymous (p.C18S), 1 novel intronic (g.942C>A), 3 known nonsynonymous (p.S23X, p.V239D, and p.I455F), and 3 known intronic (g.23034G>T, g.29641C>G, and g.33893T>C) variants. Only g.23034G>T was noted also in homozygous state in 2% patient population. However, Controls exhibited only the variations g.23034G>T and p.I455F. Therefore, present study reports for the first time that the observed novel variants in pendrin gene might be linked with autoimmune negative hypothyroidism, without any characteristics of Pendred syndrome and/or congenital hypothyroidism. While, all observed known variants/mutations were reported with either Pendred syndrome and/or congenital hypothyroidism earlier, but never with nonautoimmune adult hypothyroidism solely. Thereby, the absence of any features of Pendred syndrome and/or congenital hypothyroidism in patients with observed known nonsynonymous variants/mutations may be due to either heterozygous state of each variant or differential domain specific activity of ions trafficking in the respective organ. The analysis of amino acid change at least for p.C18S, p.S23X, and p.V239D in correlation with phenotypic characteristics of respective patients might assume a possible effect on protein structure and function. Altogether, we report for the first time that genetical variations in SLC26A4 gene could play an important role in development of nonautoimmune adult hypothyroidism.
19. Weltkongress für Psychoonkologie vom 14.-18. August 2017 in Berlin
Authors: Mehnert Anja , Lordick Florian 
Published: July 2017

Liebe Kolleginnen und Kollegen,wir freuen uns sehr, Sie im Namen der International Psycho-Oncology Society (IPOS) und dem Leipziger Kongressteam zum 19. Weltkongress für Psychoonkologie einzuladen, der vom 14.–18. August 2017 in Berlin stattfindet (www.ipos2017.com).
Niemand ist nur krank
Authors: Sonnenschmidt Rosina 
Published: July 2017

SummarySeit vielen Jahren begleitet Rosina Sonnenschmidt Patienten mit Krebs. Aus all den Erfahrungen, die sie dabei gewonnen hat, hat sie ein Behandlungskonzept abgeleitet. Neben der Miasmatik stellt sie dabei den Patienten mit seiner Individualität in den Mittelpunkt und aktiviert seine Potenziale. Sie fordert zudem Eigeninitiative von ihm, denn das eigene Tun und die Eigenverantwortung braucht es, um in den Heilungsprozess zu gelangen.
Erythropoietin for Cognitive Deficits Associated with Schizophrenia, Bipolar Disorder, and Major Depression: A Systematic Review
Authors: Li Xian-Bin , Zheng Wei , Ning Yu-Ping , Cai Dong-Bin , Yang Xin-Hu , Ungvari Gabor , Ng Chee , Wang Chuan-Yue , Xiang Yu-Tao 
Published: July 2017

Abstract
Introduction The purpose of this study is to systematically review the efficacy and safety of adjunctive erythropoietin (EPO) in treating cognitive deficits associated with schizophrenia, bipolar disorder, and major depression based on randomized controlled trials (RCTs).
Methods Two evaluators independently and systematically searched and selected studies, extracted data, and conducted quality assessment.
Results Four RCTs with 144 patients (71 in the EPO group and 73 in the placebo group) met the study entry criteria. Adjunctive EPO could improve schizophrenia-related cognitive performance. In patients with bipolar disorder, EPO could also enhance sustained attention, recognition of happy faces, and speed of complex information processing across learning, attention, and executive function when compared with placebo. In addition, EPO could enhance verbal recall, recognition, and memory in patients with major depression.
Discussion This preliminary study found that adjunctive EPO appears to be effective in treating cognitive deficits associated with schizophrenia, bipolar disorder, and major depression without major adverse effects observed. Further higher quality RCTs with larger samples are needed to confirm the findings.
Review registration: CRD42017058094
Body Composition is Different After Surgical or Pharmacological Remission of Cushing’s Syndrome: A Prospective DXA Study
Authors: Ceccato Filippo , Boccato Michela , Zilio Marialuisa , Barbot Mattia , Frigo Anna , Luisetto Giovanni , Boscaro Marco , Scaroni Carla , Camozzi Valentina 
Published: July 2017

AbstractPatients with active Cushing’s syndrome (CS) exhibit an increase of the visceral adipose tissue, increasing the risk of cardiovascular events. Until now, it is not yet clear whether remission of CS leads to a normalization of body composition, or if different strategies to control hypercortisolism could result in a different clinical outcome concerning adipose tissue distribution. Therefore, we analyzed body composition changes using dual-energy X-ray absorptiometry (DXA) in patients with CS in a prospective and controlled study. We considered 23 patients with CS, whose remission was achieved after surgery in 14 or gained with pharmacological treatment in 9 subjects. Clinical and DXA data (lean and fat mass in total body, trunk, and R1 box) were collected during active hypercortisolism and after sustained remission, defined as the normalization of both late night salivary and 24-h urinary cortisol levels, at least for 6 consecutive months. Healthy subjects, matched with CS for gender, age, and BMI, were considered as controls (n=25). After remission of hypercortisolism, body compositions of patients were similar to matched controls; fat mass in total body (−7.53%), trunk (−3.24%), and R1- box (−12.82%, all p<0.01) were decreased from baseline levels. Dividing patients by type of treatment, fat mass reduction was higher in those that achieved surgical remission of CS (total body −17.26%, trunk −22.73%, and R1 box −21.21%, all p<0.05). Surgical remission of hypercortisolism is characterized by improvement of body composition, particularly fat reduction, easily detectable with DXA during routine clinical practice.
Specific emotional schema of death-related images vs unpleasant images / Esquema emocional específico de imágenes relacionadas con la muerte frente a imágenes desagradables
Authors: Martí-García Celia , Fernández-Alcántara Manuel , Schmidt-Riovalle Jacqueline , Cruz-Quintana Francisco , García-Caro M. Paz , Pérez-García Miguel 
Published: July 2017

Understanding the specific emotional responses elicited by death and how it differs from other unpleasant stimuli is essential for understanding people’s behaviour. In study I, 113 students viewed a set of unpleasant images or images of death. Death images rated lower arousal ( p = .020, d = 0.31, CI [−.06 to .80]) and lower control ( p = .015, d = 0.68, 95% CI [.23 to .93]) than unpleasant pictures. The results also indicated that viewing death-related images did not induce a state of anxiety; in study II, 84 students (42 participants with prior experience related to death) viewed pleasant, neutral, unpleasant and death images. The participants with prior experience reported lower arousal for death-related images ( p = .004, d = 0.87, 95% CI [.45 to 1.36]). In both studies, images of death induced a specific emotional schema according to Izard’s theory that can be modulated by having previous experience.
Childlessness and vulnerability of older people in China
Authors: Feng Zhixin 
Published: July 2017

AbstractBackgroundthe number of childless older people is increasing in China, but relatively little is known about the role of childlessness in health outcomes. This study investigates the relationship between childlessness and three health outcomes: difficulty with Instrumental Activities of Daily Living (IADLs), self-rated health and depression.Methodsthis study includes 13,171 individuals aged 50 and above from national survey data of the second wave of the China Family Panel Study (2012). Binary/multinomial logistic and ordinary least squares regression models are presented.Resultschildless individuals whose children have all died exhibit worse health outcomes than individuals with children, but this effect is influenced by demographic characteristics, socio-economic status and social security. On the other hand, individuals who are childless due to other reasons (involuntary or voluntary) are less likely to report difficulty with IADLs and to report depression than older people with all children alive after controlling for demographic and socio-economic and social security factors.Conclusionsthe death of a child has an adverse effect on people’s health for both childless people whose children have all died and those who have lost a child but have other children alive. These two groups are in the most vulnerable position, which could also suggest that their children have died because they grew up in a vulnerable family. The government needs to improve the social security for these two groups and provide social services (particularly mental health services) to older people who have lost a child; these could contribute to alleviating some of the adverse effects of the death of a child.
ggseqlogo: a versatile R package for drawing sequence logos
Authors: Wagih Omar 
Published: July 2017

Abstract

Summary
Sequence logos have become a crucial visualization method for studying underlying sequence patterns in the genome. Despite this, there remains a scarcity of software packages that provide the versatility often required for such visualizations. ggseqlogo is an R package built on the ggplot2 package that aims to address this issue. ggseqlogo offers native illustration of publication-ready DNA, RNA and protein sequence logos in a highly customizable fashion with features including multi-logo plots, qualitative and quantitative colour schemes, annotation of logos and integration with other plots. The package is intuitive to use and seamlessly integrates into R analysis pipelines.

Availability and implementation
ggseqlogo is released under the GNU licence and is freely available via CRAN-The Comprehensive R Archive Network https://cran.r-project.org/web/packages/ggseqlogo. A detailed tutorial can be found at https://omarwagih.github.io/ggseqlogo.
Effect of Intrathecal Bupivacaine Dose on the Success of External Cephalic Version for Breech Presentation
Authors: Chalifoux Laurie A. , Bauchat Jeanette R. , Higgins Nicole , Toledo Paloma , Peralta Feyce M. , Farrer Jason , Gerber Susan E. , McCarthy Robert J. , Sullivan John T. 
Published: July 2017

Abstract

Background
Breech presentation is a leading cause of cesarean delivery. The use of neuraxial anesthesia increases the success rate of external cephalic version procedures for breech presentation and reduces cesarean delivery rates for fetal malpresentation. Meta-analysis suggests that higher-dose neuraxial techniques increase external cephalic version success to a greater extent than lower-dose techniques, but no randomized study has evaluated the dose–response effect. We hypothesized that increasing the intrathecal bupivacaine dose would be associated with increased external cephalic version success.

Methods
We conducted a randomized, double-blind trial to assess the effect of four intrathecal bupivacaine doses (2.5, 5.0, 7.5, 10.0 mg) combined with fentanyl 15 μg on the success rate of external cephalic version for breech presentation. Secondary outcomes included mode of delivery, indication for cesarean delivery, and length of stay.

Results
A total of 240 subjects were enrolled, and 239 received the intervention. External cephalic version was successful in 123 (51.5%) of 239 patients. Compared with bupivacaine 2.5 mg, the odds (99% CI) for a successful version were 1.0 (0.4 to 2.6), 1.0 (0.4 to 2.7), and 0.9 (0.4 to 2.4) for bupivacaine 5.0, 7.5, and 10.0 mg, respectively (P = 0.99). There were no differences in the cesarean delivery rate (P = 0.76) or indication for cesarean delivery (P = 0.82). Time to discharge was increased 60 min (16 to 116 min) with bupivacaine 7.5 mg or higher as compared with 2.5 mg (P = 0.004).

Conclusions
A dose of intrathecal bupivacaine greater than 2.5 mg does not lead to an additional increase in external cephalic procedural success or a reduction in cesarean delivery.
The bidirectional relationship between vasomotor symptoms and depression across the menopausal transition: a systematic review of longitudinal studies
Authors: Natari Rifani B. , Clavarino Alexandra M. , McGuire Treasure M. , Dingle Kaeleen D. , Hollingworth Samantha A. 
Published: July 2017

Abstract

Objective:
To explore the nature of the bidirectional relationship between vasomotor symptoms (VMS) and depression, and to determine whether hot flashes and night sweats differentially affect the association between VMS and depression through their effect on sleep disruption.

Methods:
Multiple databases were searched from 1961 until July 31, 2016, and a manual search of reference lists of identified articles was conducted. Sixteen articles that involved 10,008 participants were identified and analyzed.

Results:
The methods of analyses and measurement of VMS and depression varied across the studies. Two studies explored the bidirectional association, but only one was significant in both directions (odds ratio [OR] depression to VMS 3.06, 95% confidence interval [CI] 1.43-6.58; OR VMS to depression 8.88, 95% CI 2.57-30.68). In both cases, the association between VMS leading to depressive symptoms was stronger than the opposite. Eleven studies examined VMS leading to depression, but only five showed a significant effect (OR 1.57-1.81, P ≤ 0.02). Treating VMS and depressive symptoms as continuous variables (n = 3) diminished the relationship. Three studies showed a significant association of depression leading to VMS (OR 1.62-1.94, P ≤ 0.01). We found little evidence for a specific effect of night sweats on the association between VMS and depressive symptoms. The effect might not be related to sleep disruption.

Conclusions:
There is a bidirectional association between VMS and depressive symptoms. The menopausal transition appears to increase the risk of recurrent episodes of depression that might not be explained only by VMS. Further investigation is needed to explain the differential effect of night sweats and hot flashes on depression.
COMPARATIVE ANALYSIS OF RETINAL REATTACHMENT SURGERY WITH OR WITHOUT INTERNAL LIMITING MEMBRANE PEELING TO PREVENT POSTOPERATIVE MACULAR PUCKER
Authors: Forlini Matteo , Date Purva , Ferrari Luisa Micelli , Lorusso Massimo , Lecce Gabriella , Verdina Tommaso , Neri Giovanni , Benatti Caterina , Rossini Paolo , Bratu Adriana , D'Eliseo Domenico , Ferrari Tommaso Micelli , Cavallini Gian Maria 
Published: July 2017

Purpose:
To determine whether internal limiting membrane (ILM) peeling during pars plana vitrectomy for rhegmatogenous retinal detachment reduces the incidence of epiretinal membrane (ERM) formation.

Methods:
In this retrospective study, preoperative, intraoperative, and postoperative data from all eyes undergoing pars plana vitrectomy for rhegmatogenous retinal detachment between January 2007 and December 2013 was analyzed. All cases with at least 1-year of follow-up were included. Data collection included vision, intraoperative complications, occurrence of ERM, and spectral domain optical coherence tomography characteristics. The OCTs were retrieved for all eyes and were graded by a single masked grader.

Results:
Out of 159 eyes recruited, ILM peeling was done in 78 eyes (49%). Overall occurrence of ERM was 20%. Seven eyes (9%) in ILM peeling group and 25 eyes in the non-ILM peeling group (31%) showed ERM (P = 0.001). Postoperative vision was significantly better in eyes that had ILM peeling (0.48 ± 0.4 logarithm of the minimum angle of resolution [20/63] vs. 0.77 ± 0.6 logarithm of the minimum angle of resolution [20/125], P = 0.003). In multivariable models adjusting for type of tamponade, ILM peeling reduced the likelihood of ERM formation by 75% (P = 0.01).

Conclusion:
Internal limiting membrane peeling during pars plana vitrectomy for rhegmatogenous retinal detachment significantly reduces ERM formation in the postoperative period and is associated with better visual and anatomical outcomes.
Incidence of Active Tuberculosis and Cohort Retention Among Adolescents in Western Kenya
Authors: Nduba Videlis , van’t Hoog Anna H. , Mitchell Ellen M. H. , Borgdorff Martien , Laserson Kayla F. 
Published: July 2017

Setting:
Siaya County, with the highest tuberculosis notification rates in Kenya.

Objectives:
To determine the incidence of active tuberculosis and 1-year cohort retention in 12–18-year-old adolescents, in preparation for phase III tuberculosis vaccine trials.

Methods:
Adolescents were enrolled and followed up for 1–2 years to determine tuberculosis incidence. Adolescents with a positive tuberculin skin test, history of cohabitation with a tuberculosis case or at least 1 tuberculosis symptom received clinical and sputum examination and a chest radiograph. Definite tuberculosis cases were bacteriologically confirmed and clinical cases diagnosed by a clinician based on a suggestive chest radiograph and having clinical symptoms. Risk factors were explored using Poisson regression.

Results:
Among 4934 adolescents without tuberculosis at baseline, 26 tuberculosis cases were identified during follow-up with a corresponding incidence density of 4.4 [95% confidence interval (CI): 3.0–6.4] events per 1000 person-years of observation, 12 definite tuberculosis cases; incidence density of 2.0 (95% CI: 0.9–3.1). Having previous tuberculosis (rate ratio: 12.5; CI: 1.8–100) and presence of tuberculin skin test conversion (rate ratio: 3.4; CI: 1.5–7.7) were significantly associated with higher risk of tuberculosis. Overall (4086/4925), 83.0% of adolescents were retained in the study after 1 year of follow-up. Being female, older, out of school and being orphaned were significant risk factors for loss to follow-up.

Conclusion:
The tuberculosis incidence in adolescents will help inform future tuberculosis vaccine trial sample size calculations for this setting. The predictive factors for tuberculosis and retention can be further explored in future trials.
Central-peripheral Temperature Monitoring as a Marker for Diagnosing Late-onset Neonatal Sepsis
Authors: Leante-Castellanos José Luis , Martínez-Gimeno Antonio , Cidrás-Pidré Manuel , Martínez-Munar Gerardo , García-González Ana , Fuentes-Gutiérrez Carmen 
Published: July 2017

Background:
The prognosis for late-onset sepsis depends largely on a timely diagnosis. We assess central-peripheral temperature difference monitoring as a marker for late-onset neonatal sepsis diagnosis.

Methods:
We performed a prospective, observational study focusing on a cohort of 129 very low–birth-weight infants. Thermal gradient alteration was defined as a difference of > 2°C maintained during 4 hours. We then determined its association with the late-onset sepsis variable through logistic regression.

Results:
We enrolled 129 preterm babies in 52 months. Thermal gradient alterations showed an adjusted odds ratio for late-onset sepsis of 23.60 (95% confidence interval [CI], 6.80–81.88), with a sensitivity of 83% and negative predictive value of 94%. In 71% of cases, thermal gradient alteration was the first clinical sign of sepsis, while C-reactive protein was < 1.5 mg/dL in 64% of cases and procalcitonin < 2 ng/mL in 36%. These figures indicate potential for early diagnosis.

Conclusions:
Sustained increases of central-peripheral temperature differences are an early sign of evolving late-onset sepsis.
Zika Virus-associated Ocular and Neurologic Disorders
Authors: Şahiner Fatih , Siğ Ali Korhan , Savaşçi Ümit , Tekin Kemal , Akay Fahrettin 
Published: July 2017

Background:
It has been approximately 70 years since the discovery of the Zika virus (ZIKV). It had been established that the virus causes mild infections and is confined to Africa and Asia; however, major changes in the clinical and epidemiologic patterns of ZIKV infection have occurred in recent years. The virus has attracted intense interest because of the possible association of several autoimmune and neurodevelopmental disorders.

Methods:
We present a summary of the articles that attempt to explain the ZIKV unknowns and strengthen the association with some disorders that are thought to be related to ZIKV, by describing the discovery milestones from the initial identification of the virus to the present day.

Results:
New evidence strengthens the association between ZIKV infections and Guillain–Barré syndrome (GBS), microcephaly and various neurodevelopmental and ophthalmologic disorders as a result of numerous new clinical and experimental studies.

Conclusions:
The World Health Organization declared the end of the “Public Health Emergency of International Concern” in December 2016, but ZIKV and associated consequences remain a significant enduring public health challenge.
Passive Transcutaneous Bone Conduction Hearing Implants: A Systematic Review
Authors: Cooper Timothy , McDonald Brendan , Ho Allan 
Published: July 2017

Objective:
To systematically review the literature on currently available passive transcutaneous bone conduction hearing implants (pTCBI) with regard to complications, audiological outcomes, and quality-of-life scores.

Data Sources:
MEDLINE, EMBASE, Scopus, and Cochrane Library.

Study Selection:
All identified English-language articles reporting on the implantation of currently available pTCBI's and their complications. Both pediatric and adult patients were included. No limitation was placed on study design or level of evidence.

Data Extraction:
Complications, audiological outcomes including mean pure-tone average gain and mean speech reception threshold gain, and quality-of-life outcomes.

Data Synthesis:
Twenty-six articles were included in the review. Four hundred eighty-two pTCBIs have been reported in the literature. Major complications including skin breakdown, wound dehiscence, hematoma, seroma, and inability to use the device occurred in 5.2% of patients. Minor complications including pain and self-resolving erythema at the implant site occurred in 13.1% of the patients. The weighted mean pure-tone average gain of the two included devices was 28.4 ± 2.1 dB and the mean speech reception threshold gain was 32.9 ± 3.9 dB. Favorable quality-of-life scores have been demonstrated with pTCBIs.

Conclusion:
pTCBIs are a viable alternative to percutaneous devices in a carefully selected group of patients. These devices have demonstrated good audiological outcomes, low morbidity, and high patient satisfaction.