bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Evaluation of 0.2% Chlorhexidine Mouth Rinse with and without an Antidiscoloration System: A Clinical Study
Authors: Phad Sidheshwar G 
Published: May 2017

ABSTRACTIntroductionChlorhexidine (CHX) is considered the gold standard agent for its clinical efficacy in chemical plaque control. The addition of other active ingredients may even reduce the antiplaque effectiveness. New mouthwash containing CHX with addition of an antidiscoloration system (ADS), i.e., Plasdone K-29/32, that claims to bind to stains, increases their solubility in water and effects their removal; thus the mouthwash promises not only to prevent plaque formation but also to avoid staining.AimTo clinically evaluate the efficacy of a 0.2% CHX mouth rinse with and without an ADS.Materials and methodsThe present study was a tripleblinded, prospective, cohort, and crossover study. This study consisted of 15 subjects. Supragingival scaling and polishing were done and then subjects were asked to rinse with a randomly allocated mouthwash for 15 days. Subjects used either mouthwash A (0.2% CHX with ADS) or mouthwash B (0.2% CHX). After 15 days, the discoloration index and plaque index (PI) were recorded. After 15 days washout period, on the 30th day from baseline, supragingival scaling and polishing were carried out, and each subject used the subsequent mouthwash. On 45th day from baseline, the discoloration and PIs were recorded and comparisons were made.ResultsNo significant difference in the PI between groups I and II mouthwash was seen (p≥0.05), whereas significant difference was found in the discoloration index between groups I and II mouthwash (p≤0.05).ConclusionThe addition of Plasdone does not reduce the efficacy of CHX mouthwash. The current study also proved that CHX with ADS caused less staining than CHX alone.How to cite this articlePereira R, Phad SG. Comparative Evaluation of 0.2% Chlorhexidine Mouth Rinse with and without an Antidiscoloration System: A Clinical Study. J Contemp Dent 2017;7(1):53-56.
Comparative Evaluation of the Plaque Inhibitory Effect of a Herbal Extract containing Fluoridated Dentifrice to a Fluoridated Dentifrice: A Clinical and Microbiological Study
Authors: Kini Vineet , Thakur Mansee , Sharma Revati , Farooqui Arjumand 
Published: May 2017

ABSTRACTAimTo clinically and microbiologically evaluate and compare the plaque inhibitory effect of commercially available herbal extract containing fluoridated dentifrice to that of commercially available fluoridated dentifrice in a healthy dental cohort.Materials and methodsA single-center, double-blinded, prospective, cohort, crossover study was conducted involving 25 healthy dental student volunteers meeting inclusion criteria. Two commercially available dentifrices: (Dentifrice A: Commercially available fluoridated dentifrice; and Dentifrice B: Commercially available fluoridated dentifrice containing Bromelain, Papain, Neem, and Meswak were selected as the test products. The study was conducted in two phases of 3 weeks duration each and a washout period of 1 week. Participants were assessed at baseline and 3 weeks using Plaque index (PI) and Gingival index (GI). At 3 weeks, a supragingival plaque was collected from the lingual surface of right mandibular first molar and microbial analysis was done. Microbiological counts were expressed as colony-forming units (CFU) per sample.ResultsOn intergroup comparison, it was observed that mean reduction in PI for Dentifrice B is significantly more than that of Dentifrice A (p-value: 0.000021). There was no significant difference between the mean reduction in the GI of both Dentifrice A and Dentifrice B (p-value: 0.3040). On intergroup comparison of CFUs obtained after 3 weeks, Dentifrice B showed significantly less viable CFUs than that of Dentifrice A (p-value: 9.42E-08).ConclusionIn the current study settings, it was observed that herbal extracts in dentifrices have an additive effect with fluoride in plaque inhibition.How to cite this articleKini V, Farooqui A, Pereira R, Sharma R, Thakur M. Comparative Evaluation of the Plaque Inhibitory Effect of a Herbal Extract containing Fluoridated Dentifrice to a Fluoridated Dentifrice: A Clinical and Microbiological Study. J Contemp Dent 2017;7(1):57-61.
Primary Non-Hodgkin's Lymphoma involving Parotid Gland: A Rare Entity
Authors: Vaidya Sushrut , Natrajan Srivalli , Kadam Sneha 
Published: May 2017

ABSTRACTNon-Hodgkin's lymphomas constitute 25 to 40% of all lymphomas. The gastrointestinal tract is the most common site followed by the head and neck area. Salivary gland involvement is a very rare entity and is involved in 0.5 to 5% of all cases. Among all the major salivary glands, the parotid gland is commonly involved followed by the submandibular glands. Misdiagnosis often leads to unnecessary diagnostic procedures, which leads to delay in initiation of appropriate treatment. It is often difficult to diagnose the distinction between lymphoma developing primarily in the parotid gland tissue and in the intraparotid lymph nodes. As per the reports, primary tumors of the parotid gland show no characteristic features on diagnostic imaging, reflecting none of their histological findings. We represent a case of a 61-year-old female who presented with painless, gradually increasing mass in the right parotid region. Imaging studies were suggestive of an infiltrative mass lesion involving right the parotid gland. The patient underwent superficial parotidectomy along with the excision of the part of the deep lobe posterior to submandibular gland with facial nerve preservation. Histopathology of the resected specimen shows infiltrates of lymphocytes into the glandular parenchyma destroying its normal lobular organization and disrupting the normal glandular architecture.How to cite this articleVaidya S, Natrajan S, Kadam S. Primary Non-Hodgkin's Lymphoma involving Parotid Gland: A Rare Entity. J Contemp Dent 2017;7(1):71-75.
Hyporheic zone influences on concentration‐discharge relationships in a headwater sandstone stream
Authors: Hoagland Beth , Russo Tess A. , Gu Xin , Hill Lillian , Kaye Jason , Forsythe Brandon , Brantley Susan L. 
Published: May 2017

AbstractComplex subsurface flow dynamics impact the storage, routing, and transport of water and solutes to streams in headwater catchments. Many of these hydrogeologic processes are indirectly reflected in observations of stream chemistry responses to rain events, also known as concentration‐discharge (CQ) relations. Identifying the relative importance of subsurface flows to stream CQ relationships is often challenging in headwater environments due to spatial and temporal variability. Therefore, this study combines a diverse set of methods, including tracer injection tests, cation exchange experiments, geochemical analyses, and numerical modeling, to map groundwater‐surface water interactions along a first‐order, sandstone stream (Garner Run) in the Appalachian Mountains of central Pennsylvania. The primary flow paths to the stream include preferential flow through the unsaturated zone (“interflow”), flow discharging from a spring, and groundwater discharge. Garner Run stream inherits geochemical signatures from geochemical reactions occurring along each of these flow paths. In addition to end‐member mixing effects on CQ, we find that the exchange of solutes, nutrients, and water between the hyporheic zone and the main stream channel is a relevant control on the chemistry of Garner Run. CQ relationships for Garner Run were compared to prior results from a nearby headwater catchment overlying shale bedrock (Shale Hills). At the sandstone site, solutes associated with organo‐mineral associations in the hyporheic zone influence CQ, while CQ trends in the shale catchment are affected by preferential flow through hillslope swales. The difference in CQ trends document how the lithology and catchment hydrology control CQ relationships.
Distinct mechanisms of Korean surface temperature variability during early and late summer
Authors: Yeo Sae‐Rim , Yeh Sang‐Wook , Won Youjin , Jo Hyunsu , Kim WonMoo 
Published: May 2017

AbstractSeveral climate factors were identified that affect the surface air temperature (SAT) variations in Korea during summer (June‐July‐August). Korean summer SAT variation exhibits remarkable differences between early summer (June) and late summer (July and August). On one hand, the significant warming trend during early summer is primarily influenced by the global‐scale trend that is manifested in East Asia. The residual variability, obtained by removing warming trend from total SAT, represents Korean SAT variability independent of the global‐scale trend. This residual variability is closely related to the meridional dipole‐like air temperature structure between Korea and northeastern China, which is largely controlled by the atmospheric circulations over East Asia. However, this atmospheric structure does not originate from the remote oceanic forcing such as sea surface temperature (SST) variability over Pacific. During late summer, on the other hand, the Korean SAT is dominantly regulated by the atmospheric variability, which is closely related to the Pacific SST variability, while the contribution of global warming signal is insignificant. The SST anomalies in the central to eastern tropical Pacific lead to a dipole‐like atmospheric circulation from the tropics to East Asia, which modulates SAT in Korea. These results imply that the Korean SAT variability during early and late summer has different sources. That is, both the global‐scale trend and atmospheric variability over the East Asia should be considered in monitoring Korean SAT during early summer, whereas the SST variability in the central to eastern tropical Pacific needs more attention during late summer.
Investigating biogeographic boundaries of the Sunda shelf: A phylogenetic analysis of two island populations of Macaca fascicularis
Authors: Klegarth A.R. , Sanders S.A. , Gloss A.D. , Lane‐deGraaf K.E. , Jones‐Engel L. , Fuentes A. , Hollocher H. 
Published: May 2017

AbstractObjectivesCyclical submergence and re‐emergence of the Sunda Shelf throughout the Pleistocene served as a dynamic biogeographic landscape, across which long‐tailed macaques (Macaca fascicularis) have migrated and evolved. Here, we tested the integrity of the previously reported continental‐insular haplotype divide reported among Y and mitochondrial DNA lineages across multiple studies.Materials and MethodsThe continental‐insular haplotype divide was tested by heavily sampling wild macaques from two important biogeographic regions within Sundaland: (1) Singapore, the southernmost tip of continental Asia and (2) Bali, Indonesia, the southeastern edge of the Indonesian archipelago, immediately west of Wallace's line. Y DNA was haplotyped for samples from Bali, deep within the Indonesian archipelago. Mitochondrial D‐loop from both islands was analyzed against existing data using Maximum Likelihood and Bayesian approaches.ResultsWe uncovered both “continental” and “insular” Y DNA haplotypes in Bali. Between Singapore and Bali we found 52 unique mitochondrial haplotypes, none of which had been previously described. Phylogenetic analyses confirmed a major haplogroup division within Singapore and identified five new Singapore subclades and two primary subclades in Bali.DiscussionWhile we confirmed the continental‐insular divide among mtDNA haplotypes, maintenance of both Y DNA haplotypes on Bali, deep within the Indonesian archipelago calls into question the mechanism by which Y DNA diversity has been maintained. It also suggests the continental‐insular designation is less appropriate for Y DNA, leading us to propose geographically neutral Y haplotype designations.
Electrophilic Activation of Iodonium Ylides by Halogen‐Bond‐Donor Catalysis for Cross‐Enolate Coupling
Authors: Saito Masato , Kobayashi Yusuke , Tsuzuki Seiji , Takemoto Yoshiji 
Published: May 2017

AbstractThe umpolung alkylation of silyl enol ethers with an iodonium(III) ylide proceeds under mild conditions to afford various 1,4‐dicarbonyl compounds in high yields in the presence of a halogen‐bonding catalyst. Unlike typical transition‐metal activation processes of such ylide precursors, which tend to proceed via carbenoid intermediates, experimental and computational studies indicate that halogen bonding (XB) between the XB donor catalyst and the iodonium ylide plays a crucial role in promoting the reaction. The identification of a compatible Bronsted base catalyst enabled the extension of this method to enols generated in situ to give the corresponding adducts in good yields.
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
Authors: Goldrick Stephen , Holmes William , Bond Nicholas J. , Lewis Gareth , Kuiper Marcel , Turner Richard , Farid Suzanne S. 
Published: May 2017

ABSTRACTProduct quality heterogeneities, such as a trisulfide bond (TSB) formation, can be influenced by multiple interacting process parameters. Identifying their root cause is a major challenge in biopharmaceutical production. To address this issue, this paper describes the novel application of advanced multivariate data analysis (MVDA) techniques to identify the process parameters influencing TSB formation in a novel recombinant antibody–peptide fusion expressed in mammalian cell culture. The screening dataset was generated with a high‐throughput (HT) micro‐bioreactor system (AmbrTM 15) using a design of experiments (DoE) approach. The complex dataset was firstly analyzed through the development of a multiple linear regression model focusing solely on the DoE inputs and identified the temperature, pH and initial nutrient feed day as important process parameters influencing this quality attribute. To further scrutinize the dataset, a partial least squares model was subsequently built incorporating both on‐line and off‐line process parameters and enabled accurate predictions of the TSB concentration at harvest. Process parameters identified by the models to promote and suppress TSB formation were implemented on five 7 L bioreactors and the resultant TSB concentrations were comparable to the model predictions. This study demonstrates the ability of MVDA to enable predictions of the key performance drivers influencing TSB formation that are valid also upon scale‐up. Biotechnol. Bioeng. 2017;114: 2222–2234. © 2017 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.
Clinical outcomes of overlapping versus non‐overlapping everolimus‐eluting absorb bioresorbable vascular scaffolds: An analysis from the multicentre prospective RAI registry (ClinicalTrials.gov identifier: NCT02298413)
Authors: Tarantini Giuseppe , Mojoli Marco , Masiero Giulia , Cortese Bernardo , Loi Bruno , Varricchio Attilio , Gabrielli Gabriele , Durante Alessandro , Pasquetto Giampaolo , Calabrò Paolo , Gistri Roberto , Tumminello Gabriele , Misuraca Leonardo , Pisano Francesco , Ielasi Alfonso , Mazzarotto Pietro , Coscarelli Sebastian , Lucci Valerio , Moretti Luciano , Nicolino Annamaria , Colombo Alessandro , Olivari Zoran , Fineschi Massimo , Piraino Davide , Piatti Luigi , Canosi Umberto , Tellaroli Paola , Corrado Donatella , Rovera Chiara , Steffenino Giuseppe ,   on behalf of all RAI investigators
Published: May 2017

ObjectivesTo compare clinical outcomes of patients treated with overlapping versus non‐overlapping Absorb BVS. Background: Limited data are available on the clinical impact of stent overlap with the Absorb BVS bioresorbable stent. Methods: We compared outcomes of patients receiving overlapping or non‐overlapping Absorb BVS in the multicenter prospective RAI Registry. Results: Out of 1,505 consecutive patients treated with Absorb BVS, 1,384 were eligible for this analysis. Of these, 377 (27%) were in the overlap group, and 1,007 (73%) in the non‐overlap group. The most frequent overlap configuration was the marker‐to‐marker type (48%), followed by marker‐over‐marker (46%) and marker‐inside‐marker (6%) types. Patients of the overlap group had higher prevalence of multivessel disease and higher SYNTAX score, and required more frequently the use of intravascular imaging. At a median follow‐up of 368 days, no difference was observed between overlap and non‐overlap groups in terms of a device‐related composite endpoint (cardiac death, TV‐MI, ID‐TLR) (5.8% vs. 4.1%, P = 0.20) or of a patient‐related composite endpoint (any death, any MI, any revascularization) (15.4% vs. 12.5%, P = 0.18). Cardiac death (1.0% vs. 1.3%, P = 0.54), MI (4.5% vs. 3.6%, P = 0.51), TVR (4.5% vs. 3.6%, P = 0.51) and stent thrombosis (1.1 vs. 1.5%, P = 1.00) were also comparable between groups. When assessing outcomes of the overlap population according to overlap configurations used, no difference was observed in terms of the device‐ or patient‐related composite endpoints. Conclusions: Outcomes of patients with or without overlapping BVS were comparable at mid‐term follow‐up despite higher angiographic complexity of the overlap subset. © 2017 Wiley Periodicals, Inc.
Comparative prognostic value of postprocedural creatine kinase myocardial band and high‐sensitivity troponin T in patients with non‐ST‐segment elevation myocardial infarction undergoing percutaneous coronary intervention
Authors: Ndrepepa Gjin , Colleran Roisin , Braun Siegmund , Xhepa Erion , Hieber Julia , Cassese Salvatore , Fusaro Massimiliano , Kufner Sebastian , Laugwitz Karl‐Ludwig , Schunkert Heribert , Kastrati Adnan 
Published: May 2017

ObjectivesWe aimed to assess the prognostic value of postprocedural creatine kinase myocardial band (CK‐MB) and cardiac troponin (cTn) in patients with non‐ST‐segment elevation myocardial infarction (NSTEMI). Background: Whether postprocedural CK‐MB or cTn is a better biomarker to stratify the risk after percutaneous coronary intervention (PCI) remains unknown. Methods: This study included 2,077 patients with NSTEMI undergoing early PCI. Peak postprocedural values of CK‐MB and high‐sensitivity cTn T (hs‐cTnT) were analyzed. The primary outcome was 3‐year mortality. Results: The median values of peak postprocedural CK‐MB and hs‐cTnT were 18.3 U L−1 and 0.140 µg L−1, respectively. Overall, 211 patients died during follow‐up. There were 129 deaths in patients with CK‐MB >the median value and 82 deaths in those with CK‐MB ≤the median value (Kaplan–Meier estimates of 3‐year mortality, 18.9% and 14.0%, respectively; hazard ratio [HR] = 1.52, 95% confidence interval [CI] 1.16–2.01; P < 0.001). There were 134 deaths in patients with hs‐cTnT >the median value and 77 deaths in patients with hs‐cTnT ≤the median value (Kaplan–Meier estimates of 3‐year mortality, 19.9% and 13.2%, respectively; HR = 1.90 [1.44–2.52]; P < 0.001). After adjustment, peak postprocedural CK‐MB (adjusted HR = 1.05 [1.02–1.07], P < 0.001 for each 24 U L−1 increment) and hs‐cTnT (adjusted HR = 1.12 [1.01–1.25], P = 0.037 for each unit higher log hs‐cTnT) remained independently associated with the risk of 3‐year mortality. The C‐statistic(s) of the model with CK‐MB and hs‐cTnT were 0.789 [0.757–0.817] and 0.793 [0.762–0.821], respectively (P = 0.585). Conclusion: In patients with NSTEMI undergoing early PCI, peak postprocedural CK‐MB and hs‐cTnT are independently associated with the risk of 3‐year mortality. © 2017 Wiley Periodicals, Inc.
Safety and efficacy of clip‐based vs. suture mediated vascular closure for femoral access hemostasis: A prospective randomized single center study comparing the StarClose and the ProGlide device
Authors: Klein‐Wiele Oliver , Baliota Maria , Kara Kaffer , Käunicke Matthias , Schäfer Harald , Garbrecht Marc , Abdulghafor Marwan , Garmer Marietta , Hailer Birgit 
Published: May 2017

ObjectivesThis study is the first head‐to‐head analysis of StarClose vs. ProGlide in patients undergoing 5F or 6F percutaneous coronary catheterization or peripheral artery interventions.BackgroundThe clip based StarClose and the suture mediated ProGlide vascular closure device are well established for femoral hemostasis in endovascular therapy. However, until now no prospective randomized study compared the safety and efficacy of the two devices.MethodsThis prospective, randomized, single‐center study enrolled 505 patients (69.6 ± 11.2 years) resulting in 538 procedures due to more than one intervention in several patients: We analyzed 422 cardiac catheterization and 116 peripheral artery interventions via a common femoral artery access. Patients were randomized to StarClose or ProGlide (1:1). In‐hospital complications (major bleeding, hematoma, pseudoaneurysm, vessel occlusion, and arteriovenous fistula) and device failure were recorded. The puncture site was assessed by ultrasound in all patients prior to discharge.ResultsOverall complication rate was 3.9%. There were more complications after utilization of StarClose compared to ProGlide (5.6 vs. 2.2%, P = 0.064), which was significant in adjusted logistic regression analysis with a 2.9‐fold increased risk of complications for StarClose (P < 0.05). In the subgroup of coronary catheterizations there were significantly more complications for StarClose compared to ProGlide (1.4 vs. 5.2%, P < 0.05) with a 4.7‐fold increased risk. Device failure rate was not significantly different between the two devices.ConclusionIn this first randomized trial comparing the two closure systems complication rate was higher for StarClose with equal efficacy compared to ProGlide. © 2017 Wiley Periodicals, Inc.
A Stable N‐Annulated Perylene‐Bridged Bisphenoxyl Diradicaloid and the Corresponding Boron Trifluoride Complex
Authors: Wei Haipeng , Zhang Liyan , Phan Hoa , Huang Xiaobo , Herng Tun Seng , Zhou Jun , Zeng Wangdong , Ding Jun , Luo Shenglian , Wu Jishan , Zeng Zebing 
Published: May 2017

AbstractOrganic π‐extended radicals display unique electronic structures, and could be used as promising functional materials. However, design and synthesis of stable radicals are challenging for chemists due to their high reactivity. In this work, we synthesized a stable N‐annulated perylene‐bridged bisphenoxyl diradicaloid, and its complex with Lewis acid boron trifluoride. Their ground‐state geometric and electronic structures were systematically studied by various experimental methods, including X‐ray crystallographic analysis, variable‐temperature NMR spectroscopy, electron‐spin resonance spectroscopy (ESR), and superconducting quantum interference device (SQUID) measurements, supported by density functional theory. Both were observed as open‐shell singlet diradicaloids in the ground state. The bisphenoxyl diradicaloid demonstrated string features of strong near‐infrared (NIR) absorption, closely packed π‐dimer structure in crystals, amphoteric redox behavior with a small HOMO–LUMO energy band gap, and a rather small singlet‐triplet gap, whereas the complex showed very different photophysical, electrochemical, and magnetic properties. Our studies provide an efficient method of making stable diradicaloids by Lewis acid/base complexation.