bluuebunny/crossref_metadata_2025_split huggingface dataset:
RUSSIAN FIRST WAVE SCIENTIFIC EMIGRATION IN THE UNITED STATES OF AMERICA
Authors: Фандо Р.А. 
Published: September 2024

В статье рассмотрена история эмиграции русских ученых в США в 1918 1940 гг. Динамика миграционных процессов в США в первой половине ХХ в. была неоднородной: массовый поток беженцев из России наблюдался в первые годы после Октябрьского переворота, в 1920е гг. изза введения ограничительных квот число переселенцев стало уменьшаться, к концу 1920х гг. переезд людей из СССР практически был прекращен, в связи с запретом большевиков на свободный выезд советских граждан, исключение составляли те, кто был невозвращенцем из своих зарубежных командировок, а в 1930е гг. наблюдался новый эмиграционный всплеск, так как в Америку стали выезжать русские беженцы из стран Европы и Дальнего Востока. Российская научная эмиграция послереволюционного периода была достаточно распространенным явлением в Соединенных Штатах Америки и оказала огромное влияние на развитие различных отраслей мировой науки и техники. В статье показаны примеры успешного продолжения профессиональной карьеры известными деятелями науки и техники в американских научных учреждениях и инженерноконструкторских центрах.
The article discusses the history of emigration of Russian scientists in the United States in 1918 1940ss. Dynamics of migration processes in the United States in the first half of the twentieth century was heterogeneous: massive fl ow of refugees from Russia was observed in the first years after the October revolution in the 1920s due to the introduction of restrictive quotas, the number of immigrants began to decrease by the end of the 1920s, moving people from the USSR was practically stopped in connection with the Bolshevik prohibition in the free exit of Soviet citizens, the exception was those who was a defector from his foreign trips, and in the 1930s. there was a new emigration surge, as Russian refugees from Europe and the Far East began to travel to America. Russian scientific emigration of the postrevolutionary period was quite common in the United States of America and had a huge impact on the development of various branches of world science and technology. The article shows examples of successful continuation of professional career by wellknown scientists and technicians in American scientific institutions and engineering design centers.
NEW RECORDS OF CULICOIDES (HAEMATOMYIDIUM) PARAENSIS AND A KEY TO ADULT CULICOIDES FROM YUCATAN PENINSULA, MEXICO
Authors: HUERTA HERÓN , NAVARRETE-CARBALLO JUAN , RODRÍGUEZ-ROJAS JORGE , CORREA-MORALES FABIÁN , MANRIQUE-SAIDE PABLO 
Published: September 2024

ABSTRACT
We provide new records of Culicoides paraensis from the Yucatan Peninsula. The anthropophilic biting midge C. paraensis is the main vector of Oropouche fever virus in South and Central America. We also report Culicoides poikilonotus for the 1st time in the Yucatan Peninsula and a key to identify the species in this region of Mexico.
Covered stent deployment for a recurrent cervical internal carotid artery aneurysm referencing angioscopy: illustrative case
Authors: Hayami Hiromichi , Fukutome Kenji , Aketa Shuta , Fukumori Junji , Mitsui Takaaki , Shiraishi Yuki , Matsuoka Ryuta , Mori Naoki , Tei Rinsei , Shin Yasushi , Motoyama Yasushi 
Published: September 2024

BACKGROUND
Extracranial carotid artery aneurysms (ECAAs) are rare, and treatment guidelines are lacking. Few reports on endovascular treatments performed for ECAAs exist.

OBSERVATIONS
A 73-year-old woman with a left giant cervical internal carotid artery aneurysm was treated with overlapping closed-cell stents. The aneurysm regrew 1 year after the treatment, and then a covered stent was deployed. Angioscopy was performed to confirm neointimal development to determine the appropriate stent position before the retreatment, and it revealed that the stent struts were embedded in thick neointima for the most part but that the neointima was thin around the aneurysm neck. Multiple holes connecting to the aneurysm were observed between the stent struts. A covered stent overlapped inside the closed-cell stents, and blood flow into the aneurysm completely disappeared.

LESSONS
When deploying the covered stent for recurrent aneurysms, angioscopy is useful for confirming neointimal development and determining the appropriate stent length and position. Angioscopic observations suggest that using stents with a higher mesh density and smaller pore size can reduce the neck hole size of the aneurysm and may achieve complete occlusion of the aneurysm.
https://thejns.org/doi/10.3171/CASE24383
Acute peritumoral brainstem hemorrhage of a clival chondrosarcoma successfully treated via endoscopic endonasal surgery: illustrative case
Authors: Mitani Koki , Tanji Masahiro , Kitada Yuji , Kikuchi Masahiro , Sugimoto Akihiko , Fujimoto Masakazu , Arakawa Yoshiki 
Published: September 2024

BACKGROUND
Chondrosarcoma is typically a slow-growing tumor, and intratumoral hemorrhage is rare. Acute brainstem hemorrhage due to chondrosarcoma has rarely been reported.

OBSERVATIONS
A 77-year-old man presented with the sudden onset of headache and vomiting followed by a declining level of consciousness, progressive right hemiparesis, and left ophthalmoplegia. Magnetic resonance imaging showed pontine hemorrhage and a mass in the retroclival space compressing the brainstem. Emergency endoscopic endonasal surgery was performed. Intraoperative observation revealed that a hematoma was located in the pons and subdural space around the tumor mass, suggesting that the hematoma had likely been caused by the rupture of small vessels around the pons, not by intratumoral hemorrhage. The pathological diagnosis was chondrosarcoma. The patient recovered well and underwent radiotherapy.

LESSONS
This report describes a case of sudden neurological deterioration due to hemorrhage in a patient with chondrosarcoma of the skull base. An emergency endoscopic endonasal approach for mass reduction and hematoma removal was effective in the acute setting. This approach revealed the suspected etiology of peritumoral hemorrhage, not intratumoral hemorrhage.
https://thejns.org/doi/10.3171/CASE2460
The method of the etiological factor′s evaluation of the gingival recession, with count of their′s separately and common complicity in the pathogenesis
Authors: Nosova M. A. , Sharov A. N. , Trunin D. A. , Posnikov M. A. , Aptekar I. A. , Privalova K. A. 
Published: September 2024

Introduction. Gingival recession is a highly relevant and common dental pathology. The prevalence of recession ranges from 45,5 to 99,3 % in people of different ages, with the risk of gingival recession increasing with age. The true etiology of gingival recession, its components and the degree of their influence, jointly or separately; the influence of the environment and lifestyle on the development of pathology are poorly understood. In the literature, for example, there is no classification of etiological factors according to the degree of their influence as triggers of gingival recession. It is of scientific interest to study the causes of gingival recession, their systematisation and assessment of the degree of influence of each factor separately and together.The aim of the study is to develop a classification system of etiological factors taking into account their significance and degree of influence on the formation of gingival recessions.Materials and methods. Analysis of scientific literature, methods of classification and structuring; methods of decomposition, integration and determination of cause-and-effect relationships.Results. A model of classification of factors of the etiology of gingival recessions was proposed, elements of the structure of etiological factors of gingival recessions were determined by the degree of their influence on pathogenesis.Conclusion. Conclusions. The study and understanding of the etiology of gingival recessions allows the clinician to select a personalised treatment taking into account individual characteristics that influence the recession occurrence and its condition: congenital and acquired factors; living conditions, habits, level of hygiene, as well as other components that aggravate or compensate for the degree and level of complexity of any recession - single, multiple or generalised. It is advisable to continue the study of literature data to expand the classification and detail the structure of etiological factors.
Дослідження та аналіз мікротвердості обробленої поверхні прокатних валів
Authors: Мелконов Г.Л. 
Published: September 2024

В даній роботі наукові дослідження спрямовані на вивчення мікротвердості поверхневого шару валка, як однієї з важливих проблем у машинобудуванні. Мікротвердість і глибина наклепу поверхневого шару є одними з основних показників якості поверхні, що грають одну з найважливіших ролей при остаточній обробці готового виробу. Виходячи з цього питання дослідження та вивчення мікротвердості обробленої поверхні токарних валів при чистовому точенні чашковими рецесії, що примусово обертаються, є актуальним і затребуваним в сучасному виробництві, а особливо в машинобудуванні. Проведені в роботі дослідження дали можливість для визначення ступеня та глибини наклепаного шару в залежності від режимів різання та кута схрещування осей інструменту та заготівлі. Так само в роботі зроблено та представлено аналіз отриманих результатів у результаті дослідження. У роботі показано при яких параметрах режимів різання та кута схрещування отримано значення глибини наклепаного шару та ступеня наклепу. Також у роботі виведена емпірична формула залежності ступеня наклепаного шару від режимів різання та кута схрещування, що дає можливість вирішення поставленої мети роботи. Так як при постачанні обладнання сортових станів машинобудівні компанії та підприємства передають клієнту калібрування валків для передбачуваного профільного сортаменту, розроблені власними калібрувальними бюро, вони не займаються питанням даних калібрування та далеко не завжди мають такі властивості, як універсальність, економічність і гнучкість, що є важливим при кінцевому завершенні технологічного процесу. Тому головне завдання інженерів в галузі машинобудування – є забезпечення клієнта обладнанням для стабільного випуску кінцевої продукції, але при цьому максимально скоротивши терміни введення в дію. Тож приділена увага дослідженню та вивченню мікротвердості обробленої поверхні прокатних валів у разі використання для чистової обробки чашечних різців, що примусово обертаються є актуальним питанням. Вивчення мікротвердості проводилося залежно від режимів різання та кута схрещування осей валу та інструменту.
Consentimiento informado en práctica médica y en investigación clínica
Authors: Velastegui Hernández Rita Elizabeth , Tagua Moyolema Ana Elizabeth , Barrionuevo Torres Viviana Estefania , Sogso Chano Christian Vicente , Vargas Ortiz Bryan Nicolás , Velastegui Hernández Rommel Santiago 
Published: September 2024

Introducción. El consentimiento informado es un pilar fundamental en la práctica médica y la investigación clínica, evolucionando de un modelo paternalista a uno que enfatiza la autonomía del paciente y la toma de decisiones compartida. A lo largo del tiempo, la importancia de garantizar que los pacientes y participantes en estudios clínicos comprendan plenamente los procedimientos, riesgos y beneficios ha sido reconocida como esencial para proteger sus derechos y asegurar un trato ético. Objetivo. El objetivo de este artículo es realizar una revisión de la literatura sobre el consentimiento informado en la práctica médica y en la investigación clínica, identificando los avances, desafíos y consideraciones éticas asociadas, con el fin de proporcionar una comprensión integral y actualizada de su estado actual y su aplicación en diferentes contextos. Metodología. La metodología de la revisión se basó en una búsqueda sistemática de estudios en bases de datos académicas como PubMed, Scopus, y Web of Science. Se incluyeron artículos que abordaran el consentimiento informado en contextos médicos y de investigación clínica, publicados en los últimos diez años. Los estudios seleccionados fueron evaluados críticamente para identificar sesgos y extraer temas relevantes, como la comprensión del consentimiento por parte de los pacientes, las barreras culturales y la influencia de las innovaciones tecnológicas. Resultados. Los resultados de la revisión revelaron que, a pesar de los avances en la conceptualización del consentimiento informado, persisten desafíos significativos en su implementación. Estos incluyen la comprensión limitada por parte de los pacientes y participantes, barreras de comunicación, y diferencias culturales que complican el proceso de consentimiento. Se destaca la necesidad de herramientas tecnológicas y formación continua para los profesionales, así como la adaptación cultural del proceso de consentimiento para mejorar su eficacia y respetar los derechos de los individuos. Conclusión. El consentimiento informado en práctica médica y en investigación clínica es una piedra angular, su importancia no puede ser subestimada, porque en la medicina y la investigación continúan evolucionando, también debe hacerlo la práctica del consentimiento informado, adaptándose a nuevas tecnologías, desafíos éticos y las necesidades cambiantes de los pacientes y participantes. Área de estudio general: Medicina. Área de estudio específica: Bioética y ética médica. Tipo de estudio: Artículos originales.
Identification and validation of ferroptosis-related biomarkers in intervertebral disc degeneration
Authors: Li Chenglong , Fei Chengshuo , Le Shiyong , Lai Zhongming , Yan Bo , Wang Liang , Zhang Zhongmin 
Published: September 2024

IntroductionFerroptosis plays a significant role in intervertebral disc degeneration (IDD). Understanding the key genes regulating ferroptosis in IDD could reveal fundamental mechanisms of the disease, potentially leading to new diagnostic and therapeutic targets.MethodsPublic datasets (GSE23130 and GSE70362) and the FerrDb database were analyzed to identify ferroptosis-related genes (DE-FRGs) involved in IDD. Single-cell RNA sequencing data (GSE199866) was used to validate the specific roles and expression patterns of these genes. Immunohistochemistry and Western blot analyses were subsequently conducted in both clinical samples and mouse models to assess protein expression levels across different tissues.ResultsThe analysis identified seven DE-FRGs, including MT1G, CA9, AKR1C1, AKR1C2, DUSP1, CIRBP, and KLHL24, with their expression patterns confirmed by single-cell RNA sequencing. Immunohistochemistry and Western blot analysis further revealed that MT1G, CA9, AKR1C1, AKR1C2, DUSP1, and KLHL24 exhibited differential expression during the progression of IDD. Additionally, the study highlighted the potential immune-modulatory functions of these genes within the IDD microenvironment.DiscussionOur study elucidates the critical role of ferroptosis in IDD and identifies specific genes, such as MT1G and CA9, as potential targets for diagnosis and therapy. These findings offer new insights into the molecular mechanisms underlying IDD and present promising avenues for future research and clinical applications.
Genetic support of causal association between lipid and glucose metabolism and stress urinary incontinence in women: a bidirectional Mendelian randomization and multivariable-adjusted study
Authors: Xiang Nanyan , Su Shiqi , Yang Yong , Luo Yurui , Fu Tingting , Wang Le , Lin Yifei , Huang Jin 
Published: September 2024

BackgroundStress urinary incontinence (SUI) is a common condition characterized by urethral sphincter failure and urine leakage. Its prevalence in women is higher than in men, and estimates of crude prevalence rates vary widely due to factors such as research methodologies, study populations, and underreporting by patients. This variability hinders research and impacts patient diagnosis, treatment, and quality of life. The complex etiology of SUI is not fully understood, and previous studies have primarily focused on non-invasive indicators. While emerging observational research suggests a correlation between SUI in women and abnormalities in lipid and blood metabolism, the underlying biological mechanisms and causal relationships require further investigation. This study aims to explore the causalities between SUI in women and lipid and blood metabolism.MethodsUsing bidirectional univariate Mendelian randomization (MR), we investigated the causal association between SUI liability in women (case/control = 5,924/399,509) from UK Biobank and lipid and glucose metabolism, indicated by total cholesterol (TC, N = 61,166), low-density lipoproteins (LDL, N = 58,381), high-density lipoproteins (HDL, N = 60,812), triglycerides (TG, N = 60,027), fasting glucose (FG, N = 19,745), and fasting insulin (FI, N = 38,238) from ENGAGE consortium. To account for potential confounding effects, multivariable MR (MVMR) analyses were performed, adjusting for body mass index (BMI) and separately among lipid and glucose metabolism.ResultsWe found that increased genetically proxied TC, LDL, and HDL levels were associated with an elevated risk of SUI in women (OR: 1.090–1.117, all P &lt; 0.05), These associations were further supported by MVMR analyses with adjustment for BMI (OR: 1.087–1.114, all P &lt; 0.05). Conversely, increased FG and FI were associated with reduced SUI reliability in women (OR: 0.731–0.815, all P &lt; 0.05). When adjusting among lipid and glucose metabolism, only HDL and FI demonstrated causal effects. Reverse MR analyses provided no genetic evidence supporting the causal effect of SUI in women on lipid and blood metabolism (all P &gt; 0.05).ConclusionsOur results reported that increased TC, LDL, and HDL are linked to higher SUI susceptibility in women, while higher FG and FI levels have a protective effect. In overweight/obese women with metabolic abnormalities, the positive associations between TC, LDL, and HDL levels and SUI indicate a higher risk.
Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis
Authors: Song Jingshuang , Yang Huawei 
Published: September 2024

BackgroundThe proteome is a crucial reservoir of targets for cancer treatment. While some targeted therapies have been developed, there are still significant challenges in early diagnosis and treatment, highlighting the need to identify new biomarkers and therapeutic targets for breast cancer. Therefore, we conducted a comprehensive proteome-wide Mendelian randomization (MR) study to identify novel biomarkers and potential therapeutic targets for breast cancer.MethodsProtein quantitative trait locus (pQTL) data were extracted from two published plasma proteome-wide association studies. Genetic variants associated with breast cancer were obtained from the Breast Cancer Association Consortium, which included 133,384 cases and 113,789 controls, and the Finnish cohort study, comprising 18,786 cases and 182,927 controls. We employed summary-based MR and colocalization methods to identify potential drug targets for breast cancer, which were subsequently validated using a two-sample MR approach. Finally, a protein-protein interaction (PPI) network was constructed to detect interactions between the identified proteins and existing cancer drug targets.ResultsGene-predicted levels of ten proteins were associated with breast cancer risk. Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. Among these, CASP8 and DDX58 were supported by tier-one evidence, while CPNE1, ULK3, PARK7, and TNFRSF9 received tier-two evidence support. The remaining proteins, TNXB, BTN2A1, DNPH1, and TLR1, were supported by tier-three evidence. CASP8, DDX58, CPNE1, ULK3, PARK7, and TNFRSF9 have already been identified as targets in drug development and potential therapeutic targets for breast cancer treatment. Additionally, ULK3 showed promise as a prognostic biomarker for breast cancer.ConclusionsThe present study identified several novel potential drug targets and biomarkers for breast cancer, providing new insights into its diagnosis and treatment. The integration of PPI and druggability evaluations enhances the prioritization of these therapeutic targets, paving the way for future drug development efforts.
Strategic management of nano-fertilizers for sustainable rice yield, grain quality, and soil health
Authors: Sahoo Bignyan Ranjan , Dash Ashish Kumar , Mohapatra Kiran Kumar , Mohanty Shraddha , Sahu Suman G. , Sahoo Bidwan Ranjan , Prusty Meenakhi , Priyadarshini Elora 
Published: September 2024

Conventional fertilizers, although widely available, are relatively low in nutrient use efficiency and cause serious environmental concerns like eutrophication, greenhouse gas (GHG) emissions, nitrate poisoning, and soil pollution. With this in mind, a randomized block design (RBD) experiment was conducted in an experimental field taking 10 treatments and 3 replications to investigate the effects of integrated approaches of nano-formulated DAP fertilizer applications on rice growth, yield, and nutrient use efficiency over conventional approaches. The result revealed that plant height, panicle length, number of tillers hill−1, total number of grain panicle−1, and root length were maximum in T10 treatment (50% of the soil test recommended doses (STD) for N and P + seedling root dipping (SRD) with nano DAP at 5 mL L−1 + twice foliar sprays (FS) with nano DAP at 4 mL L−1 at 25 and 45 DAT (date after transplanting). The highest mean grain yields (4.12 and 4.05 Mg ha−1) and nutrient uptake were recorded in the T2 treatment (100% STD), but this was at par with T10 treatment. The highest benefit–cost ratio (2.26) was recorded in T10, which was 3.5% higher than T2. N and P agronomic use efficiency (AUE) ranged from 7.5% to 31.5% and 15% to 63%, and recovery efficiency (RE) ranged from 30% to 94.2% and 11.2% to 90.4%. The highest nutrient use efficiency was recorded with T10, followed by T9, and lowest in T4. Post-harvest soil pH and available N and P were significantly highest in T10. Soil MBC, MBN, MBP, urease, and phosphatase activity were found significantly higher in T2, followed by T10. The integrated application of 50% STD for N and P + SRD with nano DAP at 5 mL L-1 + twice FS with nano DAP at 4 mL L−1 at 25 and 45 DAT application can be a suitable substitute for conventional DAP and urea for rice in climate-smart agriculture as it possibly reduces environmental pollution while undisturbing crop yield over the 100% STD.