bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Oxypalladation Initiating the Oxidative Heck Reaction with Alkenyl Alcohols: Synthesis of Isocoumarin—Alkanones.
Authors: Zheng Meifang , Huang Liangbin , Tong Qizhen , Wu Wanqing , Jiang Huanfeng 
Published: June 2016

AbstractThis one‐pot Pd‐catalyzed cascade cyclization of internal alkynes with alkenyl alcohols is advantageous with regards to mild conditions, good functional group tolerance and can be performed with unactivated alkenes.
ChemInform Abstract: Towards Isocoumarin‐Fused Enediyne Systems Through the Electrophilic Cyclization of Methyl o‐(Buta‐1,3‐diynyl)benzoates.
Authors: Danilkina Natalia A. , Gurskaya Larisa Y. , Vasilyev Aleksander V. , Balova Irina A. 
Published: June 2016

AbstractElectrophilic cyclization of diynylbenzoates (I) followed by Sonogashira coupling of the resulting 4‐iodoisocoumarins with acetylenes affords the title products (IV).
ChemInform Abstract: Rhodium‐Catalyzed Selective C—H Functionalization of NNN Tridentate Chelating Compounds via a Rollover Pathway.
Authors: Hong Seung Youn , Kwak Jaesung , Chang Sukbok 
Published: June 2016

AbstractAn unprecedented NHC‐catalyzed bis‐alkylation of N,N,N‐tridentate chelating molecules is developed.
ChemInform Abstract: Synthesis of 8‐Heteroaryl Nitroxoline Analogues via One‐Pot Sequential Pd‐Catalyzed Coupling Reactions.
Authors: Brodnik Helena , Pozgan Franc , Stefane Bogdan 
Published: June 2016

AbstractA series of title compounds (III) are prepared by Suzuki—Miyaura‐coupling of organoboron reagents (II) with bromoquinolines (I).
ChemInform Abstract: An Efficient Synthesis of Sulfonated Quinoline Diones by Copper Catalyzed Sulfonylation of Activated Alkenes with Sulfonylhydrazides.
Authors: Wang Shucheng , Huang Xuhu , Wang Qi , Ge Zemei , Wang Xin , Li Runtao 
Published: June 2016

AbstractA synthesis of sulfonated quinoline diones (III) by copper‐catalyzed sulfonylation of activated alkenes with sulfonylhydrazides (II) is described.
ChemInform Abstract: Organocatalytic Fluoromalonate Addition to Tetrahydroisoquinolines Through a CDC Process.
Authors: Shirley Luke D. , Ceban Victor , Meazza Marta , Rios Ramon 
Published: June 2016

AbstractA new methodology for the synthesis of fluorinated compounds based on the organo catalytic cross dehydrogenative coupling of tetrahydroisoquinolines with fluoromalonates is developed.
ChemInform Abstract: Substituted Quinolinones. Part 27. Regioselective Synthesis of Pyrazolo‐, Oxazolo‐, and Triazepinoquinoline Derivatives.
Authors: Abass Mohamed , Hassanin Hany M. , Allimony Hassan A. , Hassan Heba 
Published: June 2016

AbstractThe structure of the reaction product depends not only on the utilized reagent, but also on the solvent and reaction temperature.
ChemInform Abstract: 2‐Aminopyridines as an α‐Bromination Shuttle in a Transition Metal‐Free One‐Pot Synthesis of Imidazo[1,2‐a]pyridines.
Authors: Roslan Irwan Iskandar , Ng Kian‐Hong , Chuah Gaik‐Khuan , Jaenicke Stephan 
Published: June 2016

AbstractA wide range of imidazo[1,2‐a]pyridines are accessible from cheap and readily available 2‐aminopyridines and 1,3‐dicarbonyl compounds.
ChemInform Abstract: Synthesis of Novel Fluorescent 12a‐Aryl Substituted Indoxylisoquinolines via Aryne‐Induced Domino Process.
Authors: Varlamov A. V. , Guranova N. I. , Novikov R. A. , Ilyushenkova V. V. , Khrustalev V. N. , Baleeva N. S. , Borisova T. N. , Voskressensky L. G. 
Published: June 2016

AbstractThe title compounds are prepared involving an aryne‐induced migration of the aryl‐anion in aryloxy substituted dihydroisoquinolines.The compounds show fluorescence properties and are characterized by green‐shifted spectra and moderate quantum yield.
ChemInform Abstract: Facile Synthesis of Multifunctional Pyrrole[2,1‐a]isoquinolin‐3(2H)‐ones via Sulfa‐Michael‐Triggered One‐Pot Reactions.
Authors: Qin Tian‐You , Cheng Lu , Jang Ho‐Chol , Zhang Sean Xiao‐An , Liao Wei‐Wei 
Published: June 2016

AbstractSulfur‐containing pyrroloisoquinolinones are rapidly synthesized by a general method involving a sulfa‐Michael‐triggered tandem reaction and subsequent lactamization reaction.
ChemInform Abstract: Transition‐Metal‐Free Synthesis of Indolizines from Electron‐Deficient Alkenes via One‐Pot Reaction Using TEMPO as an Oxidant
Authors: Shi Fei , Zhang Yu , Lu Zhaole , Zhu Xiaolei , Kan Weiqiu , Wang Xiang , Hu Huayou 
Published: June 2016

Abstractand various pyridines and α‐halo carbonyl compounds as further substrates
ChemInform Abstract: Efficient Synthetic Route Toward Biologically Active γ‐Carboline Derivatives.
Authors: Hingane Dattatray G. , Parekh Nikita P. , Khan Ayesha , Kusurkar Radhika S. 
Published: June 2016

AbstractAn efficient and short methodology is established to form the biologically active γ‐carboline derivatives (II) using a thermal electrocyclization strategy.
ChemInform Abstract: A New Synthesis of 4‐ or/and 6‐CF3‐Containing Hexahydro‐ and 1,2,3,4‐Tetrahydropyrimidin‐2‐ones.
Authors: Solovyev Pavel A. , Fesenko Anastasia A. , Shutalev Anatoly D. 
Published: June 2016

AbstractThe amidoalkylation of Na‐enolates of 1,3‐dicarbonyl compounds with N‐(tosylalkyl)‐ or N‐(acetoxyalkyl)ureas affords hexahydropyrimidinones or their acyclic isomers, which are dehydrated with TosOH to give corresponding tetrahydropyrimidinones.
ChemInform Abstract: Synthesis of Several New 1‐Arylpyrazolo[3,4‐d]pyrimidines Containing an Amide Moiety.
Authors: Liu Ju , Zhang Xin‐Wei , Song Duan‐Zheng , Cai Zhi‐qiang , Zhou Yun‐peng 
Published: June 2016

Abstract9 Title compounds of type (VI) are prepared by condensation of (IV) with various acids (V).
ChemInform Abstract: Rhodium‐Catalyzed Tandem C—H Activation and Aza‐Michael Addition of 2‐Arylquinazolin‐4‐ones with Acrylates for the Synthesis of Pyrrolo[2,1‐b]quinazolin‐9(1H)‐one Derivatives.
Authors: Jiang Xin , Yang Qin , Yuan Jianjun , Deng Zhihong , Mao Xuechun , Peng Yiyuan , Yu Chuyi 
Published: June 2016

AbstractA tandem C—H activation/aza‐Michael reaction of quinazolinones (I) with acrylic esters is achieved in the presence of a dual Rh/Ag‐catalyst to provide pyrrolo[2.1‐b]quinazolin‐9(1H)‐ones in good to excellent yields.
ChemInform Abstract: Synthesis of the Symmetrical 3,5‐Bis(difluoromethyl)‐1,4‐thiazine 1,1‐Dioxides.
Authors: Ogurok Volodymyr M. , Siry Sergiy A. , Rusanov Eduard B. , Vlasenko Yuriy G. , Shermolovich Yuriy G. 
Published: June 2016

AbstractThe title compounds are prepared by heterocyclization of bis(tetrafluoropropyl)sulfone with ammonia or primary amines.
ChemInform Abstract: A Practical Approach for the Synthesis of Novel Triazolo‐Fused Benzazepine Derivatives Using a Multi‐Component Reaction and an Intramolecular C—H Arylation.
Authors: Homami Seyed Saied , Rezaei Zahra 
Published: June 2016

Abstract8 Title compounds of type (VI) are prepared by a four‐component Ugi reaction followed by formation of the triazole ring by click reaction with NaN3.
ChemInform Abstract: Synthesis of Quinoline‐Fused 1‐Benzazepines Through a Mannich‐Type Reaction of a C,N‐Bisnucleophile Generated from 2‐Aminobenzaldehyde and 2‐Methylindole.
Authors: Min Lijun , Pan Bin , Gu Yanlong 
Published: June 2016

AbstractA variety of quinoline‐fused benzazepines are synthesized via Mannich‐type reactions of a C,N‐bisnucleophile such as (VII).
ChemInform Abstract: Phosphinic Amide as Directing Group Enabling Palladium(II)‐Catalyzed ortho C—H Alkenylation of Anilines Without and with Alkylation at the Nitrogen Atom.
Authors: Jiao Lin‐Yu , Ferreira Andre V. , Oestreich Martin 
Published: June 2016

AbstractThe new directing group of aniline derived phosphinic amides allows couplings of both secondary (with NH group) and tertiary (with NMe group).
ChemInform Abstract: Syntheses of Bimetallic Rare‐Earth Bis(cyclopentadienyl) Derivatives Supported by Bridged Bis(guanidinate) Ligands and Their Catalytic Property for the Hydrophosphonylation of Aldehydes.
Authors: Nie Kun , Liu Chengwei , Zhang Yong , Yao Yingming 
Published: June 2016

AbstractThe novel organo‐rare‐earth metal complexes are efficient catalysts for the hydrophosphonylation of various aldehydes affording α‐hydroxyphosphonates in high yields under mild reaction conditions.
ChemInform Abstract: Analgesic Corynanthe‐Type Alkaloids from Strychnos angustiflora.
Authors: Jiang Hua , Liu Yun‐Bao , Li Yong , Li Li , Ma Shuang‐Gang , Qu Jing , Yu Shi‐Shan 
Published: June 2016

AbstractNine new and five known corynanthe alkaloids are isolated as exemplified by the structures shown in the scheme.
ChemInform Abstract: Supramolecular Transformations within Discrete Coordination‐Driven Supramolecular Architectures
Authors: Wang Wei , Wang Yu‐Xuan , Yang Hai‐Bo 
Published: June 2016

AbstractReview: [summary of supramolecular transformations within discrete coordination‐driven supramolecular architectures, including helices, metallacycles, metallacages, etc.; 146 refs.
ChemInform Abstract: Anion Sensors as Logic Gates: A Close Encounter
Authors: Madhuprasad Madhuprasad , Bhat Mahesh P. , Jung Ho‐Young , Losic Dusan , Kurkuri Mahaveer D. 
Published: June 2016

AbstractReview: recent advances and progress on development of ion receptors for molecular logic gates, and a brief idea about the application of molecular logic gates; 127 refs.
Mass Spectrometric Observation of Doubly Charged Alkaline‐Earth Argon Ions
Authors: Hattendorf Bodo , Gusmini Bianca , Dorta Ladina , Houk Robert S. , Günther Detlef 
Published: June 2016

AbstractDoubly charged diatomic ions MAr2+ where M=Mg, Ca, Sr or Ba have been observed by mass spectrometry with an inductively coupled plasma ion source. Abundance ratios are quite high, 0.1 % for MgAr2+, 0.4 % for CaAr2+, 0.2 % for SrAr2+ and 0.1 % for BaAr2+ relative to the corresponding doubly charged atomic ions M2+. It is assumed that these molecular ions are formed through reactions of the doubly charged metal ions with neutral argon atoms within the ion source. Bond dissociation energies (D0) were calculated and agree well with previously published values. The abundance ratios MAr+/M+ and MAr2+/M2+ generally follow the predicted bond dissociation energies with the exception of MgAr2+. Mg2+ should form the strongest bond with Ar [D0 (MgAr2+)=124 to 130 kJ mol−1] but its relative abundance is similar to that of the weakest bound BaAr2+ (D0=34 to 42 kJ mol−1). The relative abundances of the various MAr2+ ions are higher than those expected from an argon plasma at T=6000 K, indicating that collisions during ion extraction reduce the abundance of the MAr2+ ions relative to the composition in the source. The corresponding singly charged MAr+ ions are also observed but occur at about three orders of magnitude lower intensity than MAr2+.
Differentiating between benign follicular nodules and follicular neoplasms in thyroid liquid‐based cytology preparations
Authors: Suzuki Ayana , Hirokawa Mitsuyoshi , Higuchi Miyoko , Takada Nami , Yamao Naoki , Kuma Seiji , Miyauchi Akira 
Published: June 2016

BackgroundThe cytological morphology observed in liquid‐based cytology (LBC) preparations is dissimilar to that of conventional preparations. The aim of this report is to clarify the cytological differences between benign follicular nodules (BFNs) and follicular neoplasms (FNs) in LBC preparations and identify novel diagnostic criteria for LBC preparations.MethodsA retrospective review of LBC preparations from 38 BFN and 74 FN (57 follicular adenomas and 17 follicular carcinomas) cases confirmed by histological examination was conducted. LBC samples were obtained from the washout fluid in aspiration needles, fixed with CytoRich‐REDTM, and prepared using the SurePathTM method.ResultsFibrin was observed in 43.2% of FNs and in 23.7% of BFNs. The incidences of intercellular spaces, distinct outer margin, and cytoplasmic process were significantly higher in BFNs (P < 0.01, P < 0.01, and P < 0.05, respectively). Elongated microfollicles were seen in 55.4% of FNs and 10.5% of BFNs (P < 0.01). Membranous materials encircling the outer edge of the follicles were observed only in BFN cases (5.8%). There were no significant differences between follicular adenoma and carcinoma.ConclusionIntercellular spaces, distinct outer margins of the follicular clusters, cytoplasmic process, and membranous materials constitute indicators of BFN in LBC preparations. Fibrin and elongated microfollicles point to FN. We believe that these findings will improve the diagnostic accuracy of thyroid LBC preparations. Diagn. Cytopathol. 2016;44:659–664. © 2016 Wiley Periodicals, Inc.
Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status
Authors: Gartstein Maria A. , Hookenson Kaia V. , Brain Ursula , Devlin Angela M. , Grunau Ruth E. , Oberlander Tim F. 
Published: June 2016

AbstractThe role of prenatal Selective Serotonin Reuptake Inhibitor (SSRI) exposure and SLC6A4 promoter methylation status in shaping soothability at 3 and 6 months of age, for infants exposed to antidepressant medication prenatally (n = 46) and those not exposed (n = 69) was investigated. SSRI exposure status and duration of exposure (number of days) were examined along with neonatal methylation status at mean CpG 9,10 and via factor analysis across 10 CpG sites yielding PC1 (CpGs sites: 3,4,5,7) and PC2 (CpG 1,8). Analyses revealed interactions for methylation markers and SSRI exposure variables. A significant interaction between SSRI exposure and mean SLC6A4 methylation at CpG 9,10 and separately for PC1 emerged, controlling for multiple birth/medical and background covariates (e.g., Apgar scores, maternal education). Increased neonatal methylation status was associated with increased soothability changes from 3 to 6 months among infants prenatally exposed to SSRIs.
Children's cortisol responses to a social evaluative laboratory stressor from early to middle childhood
Authors: Leppert Katherine A. , Kushner Marissa , Smith Victoria C. , Lemay Edward P. , Dougherty Lea R. 
Published: June 2016

AbstractThis study examined the stability of children's cortisol responses to a social evaluative laboratory stressor from early to middle childhood. Ninety‐six children (51 males) completed stress‐inducing laboratory tasks and provided five salivary cortisol samples in early (W1) and middle (W2) childhood. Although W1 cortisol responses did not predict W2 cortisol responses, children's cortisol responses demonstrated change: compared to their W1 cortisol responses, children's W2 cortisol responses demonstrated an increased slope and more negative quadratic curvature. Furthermore, child psychiatric symptoms at W1 moderated the stability of children's cortisol responses. Children with fewer preschool psychiatric symptoms demonstrated greater inter‐individual and intra‐individual stability, whereas children with higher preschool psychiatric symptoms and comorbidity demonstrated systematic inter‐individual and intra‐individual instability in cortisol responses over time. Findings suggest a developmental shift toward increasing cortisol stress responses from early to middle childhood and highlight preschool psychopathology as a moderator of stability in children's cortisol responses over time.
Glucose time series complexity as a predictor of type 2 diabetes
Authors: Rodríguez de Castro Carmen , Vigil Luis , Vargas Borja , García Delgado Emilio , García Carretero Rafael , Ruiz‐Galiana Julián , Varela Manuel 
Published: June 2016

AbstractBackgroundComplexity analysis of glucose profile may provide valuable information about the gluco‐regulatory system. We hypothesized that a complexity metric (detrended fluctuation analysis, DFA) may have a prognostic value for the development of type 2 diabetes in patients at risk.MethodsA total of 206 patients with any of the following risk factors (1) essential hypertension, (2) obesity or (3) a first‐degree relative with a diagnosis of diabetes were included in a survival analysis study for a diagnosis of new onset type 2 diabetes. At inclusion, a glucometry by means of a Continuous Glucose Monitoring System was performed, and DFA was calculated for a 24‐h glucose time series. Patients were then followed up every 6 months, controlling for the development of diabetes.ResultsIn a median follow‐up of 18 months, there were 18 new cases of diabetes (58.5 cases/1000 patient‐years). DFA was a significant predictor for the development of diabetes, with ten events in the highest quartile versus one in the lowest (log‐rank test chi2 = 9, df = 1, p = 0.003), even after adjusting for other relevant clinical and biochemical variables. In a Cox model, the risk of diabetes development increased 2.8 times for every 0.1 DFA units. In a multivariate analysis, only fasting glucose, HbA1c and DFA emerged as significant factors.ConclusionsDetrended fluctuation analysis significantly performed as a harbinger of type 2 diabetes development in a high‐risk population. Complexity analysis may help in targeting patients who could be candidates for intensified treatment. Copyright © 2016 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons Ltd.
Merging and comparing three mitochondrial markers for phylogenetic studies of Eurasian reindeer (Rangifer tarandus)
Authors: Kvie Kjersti S. , Heggenes Jan , Røed Knut H. 
Published: June 2016

AbstractPhylogenetic analyses provide information that can be useful in the conservation of genetic variation by identifying intraspecific genetic structure. Reconstruction of phylogenetic relationships requires the use of markers with the appropriate amount of variation relative to the timeframe and purpose of the study. Here, genetic structure and clustering are inferred from comparative analyses of three widely used mitochondrial markers, the CR, cytb and the COI region, merged and separately, using Eurasian reindeer as a model. A Bayesian phylogeny and a MJ network, both based on the merged dataset, indicate several distinct maternal haplotype clusters within Eurasian reindeer. In addition to confirm previously described clusters, two new subclusters were found. When comparing the results from the merged dataset with the results from analyses of the three markers separately, similar clustering was found in the CR and COI phylogenies, whereas the cytb region showed poor resolution. Phylogenetic analyses of the merged dataset and the CR revealed congruent results, implying that single sequencing analysis of the CR is an applicable method for studying the haplotype structure in Eurasian reindeer.
Scaling up functional traits for ecosystem services with remote sensing: concepts and methods
Authors: Abelleira Martínez Oscar J. , Fremier Alexander K. , Günter Sven , Ramos Bendaña Zayra , Vierling Lee , Galbraith Sara M. , Bosque‐Pérez Nilsa A. , Ordoñez Jenny C. 
Published: June 2016

AbstractEcosystem service‐based management requires an accurate understanding of how human modification influences ecosystem processes and these relationships are most accurate when based on functional traits. Although trait variation is typically sampled at local scales, remote sensing methods can facilitate scaling up trait variation to regional scales needed for ecosystem service management. We review concepts and methods for scaling up plant and animal functional traits from local to regional spatial scales with the goal of assessing impacts of human modification on ecosystem processes and services. We focus our objectives on considerations and approaches for (1) conducting local plot‐level sampling of trait variation and (2) scaling up trait variation to regional spatial scales using remotely sensed data. We show that sampling methods for scaling up traits need to account for the modification of trait variation due to land cover change and species introductions. Sampling intraspecific variation, stratification by land cover type or landscape context, or inference of traits from published sources may be necessary depending on the traits of interest. Passive and active remote sensing are useful for mapping plant phenological, chemical, and structural traits. Combining these methods can significantly improve their capacity for mapping plant trait variation. These methods can also be used to map landscape and vegetation structure in order to infer animal trait variation. Due to high context dependency, relationships between trait variation and remotely sensed data are not directly transferable across regions. We end our review with a brief synthesis of issues to consider and outlook for the development of these approaches. Research that relates typical functional trait metrics, such as the community‐weighted mean, with remote sensing data and that relates variation in traits that cannot be remotely sensed to other proxies is needed. Our review narrows the gap between functional trait and remote sensing methods for ecosystem service management.
The relevance of spatial variation in ecotourism attributes for the economic sustainability of protected areas
Authors: De Vos Alta , Cumming Graeme S. , Moore Christine A. , Maciejewski Kristine , Duckworth Gregory 
Published: June 2016

AbstractIn contemporary society, protected areas are increasingly expected to justify their existence through the services that they provide to society. Protected areas offer many important cultural services, but appraisal of these nonmaterial benefits has generally proven difficult and most studies have focused on single case studies. Data on tourist numbers across multiple camps and protected areas provide a tractable and previously unexploited case study for better understanding the economic sustainability of cultural service provision and the relevance of potentially confounding variables (e.g., location and infrastructure) for park sustainability. We used redundancy analysis and linear models to relate a 5‐yr monthly data set (2007–2012) of tourist numbers and tourism‐derived income in all camps in South African national parks to a set of largelyGIS‐derived, determinant attributes that captured key elements of location, biodiversity, infrastructure, and accommodation cost at a camp level. Our analysis suggests that the degree to which cultural services can be converted into revenue for conservation is strongly contingent on infrastructure, location, and the business model that the park adopts. When considered alone, ecological attributes explained 14.2% and 3% of day and overnight visitation rates, respectively. In contrast, models that considered ecosystems in combination with other elements could explain 53% and 67% of variation. Linear models confirmed the existence of complex interactions between groups of variables and highlighted individual covariates that affected visitation rates. Significant variables included ecological features that provided aesthetic services, number of water bodies, elevation, available units, unit costs, and distance to the coast, airports, and other national parks. Taken in context our results suggest that it may be simpler than expected to make predictions about the potential future economic viability of protected areas under alternative models of management, illustrate how ecological variables may represent the “supply” side in cultural services, and highlight the complex interplay between ecological and built infrastructure. Encouragingly, this in turn suggests that relatively small, targeted investments in infrastructure could lead to disproportionate increases in tourist visitation rates and hence in increased revenue for conservation.