bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additional Value of Different Radiographic Views on the Identification of Early Radiographic Hip and Knee Osteoarthritis and Its Progression: A Cohort Study
Authors: Damen Jurgen , Runhaar Jos , Kloppenburg Margreet , Meijer Rik , Bierma‐Zeinstra Sita M. A. , Oei Edwin H. G. 
Published: January 2017

ObjectiveTo investigate the prevalence and progression of early radiographic osteoarthritis (OA) of the hip and knee on different radiographic views, to determine whether different radiographic views have additional value in detecting early hip and knee radiographic OA cases or progression.MethodsIn the Cohort Hip and Cohort Knee (CHECK) study (n = 1,002), 5 different radiographs were obtained: an anteroposterior and faux profile view of the hips, and posteroanterior, mediolateral, and skyline views of the knees. The prevalence of radiographic OA was estimated based on each view separately and in combinations. We determined whether different radiographic views have additional value in detecting and determining the progression of radiographic OA cases, compared to standard projections.ResultsIn the hip, we found 22.9% more cases when we combined both views. In the knee, we detected 79.7% more radiographic OA cases when we combined information from all 3 different radiographic views than when using only the posteroanterior view. Progression was seen in 33.1% more cases when using 2 hip radiographs, and in 65.1% more cases when using 3 knee radiographs.ConclusionThe use of different radiographic views increased the number of participants classified as having radiographic OA in an early OA cohort, both at baseline and at followup. The progression of early radiographic OA is demonstrated more frequently when multiple different radiographic views are used.
Shuttle Catalysis—New Strategies in Organic Synthesis
Authors: Bhawal Benjamin N. , Morandi Bill 
Published: January 2017

AbstractShuttle catalysis has recently emerged as a powerful new concept that provides a platform for performing both functionalization and defunctionalization reactions. In this concept article, applications of shuttle catalysis as a novel strategy in organic synthesis are discussed. This includes using forward shuttle catalysis reactions for challenging bond‐forming processes that avoid the use of hazardous chemicals. Shuttle catalysis also facilitates the transfer of reactive functionality as a route to procure a broad range of compounds using one simple procedure. Reverse shuttle catalysis reactions are also discussed as a method for the valorization of biomass and waste materials. Another area of interest, shuttle‐catalysis‐assisted reactions, wherein the transfer of a small molecule is utilized in a catalytic cycle, is also described. Possible future directions in this exciting new field are also suggested.
Highly Flexible Multifunctional Biopaper Comprising Chitosan Reinforced by Ultralong Hydroxyapatite Nanowires
Authors: Sun Tuan‐Wei , Zhu Ying‐Jie , Chen Feng 
Published: January 2017

AbstractInvited for the cover of this issue are Ying‐Jie Zhu, Feng Chen et al. at the Chinese Academy of Sciences. The image depicts the highly flexible multifunctional biopaper comprising ultralong hydroxyapatite nanowires and chitosan for biomedical applications such as wound dressing, bone‐fracture fixation and bone‐defect repair. Read the full text of the article at 10.1002/chem.201605165.
Biodiversity in agricultural landscapes: The effect of apple cultivar on epiphyte diversity
Authors: Stevenson C. Robin , Davies Chantel , Rowntree Jennifer K. 
Published: January 2017

AbstractIn natural systems, extended phenotypes of trees can be important in determining the species composition and diversity of associated communities. Orchards are productive systems where trees dominate, and can be highly biodiverse, but few studies have considered the importance of tree genetic background in promoting associated biodiversity. We tested the effect of apple cultivar (plant genetic background) on the diversity and composition of the associated epiphytic bryophyte community across a total of seven cultivars in five productive East Anglian orchards where each orchard contained two cultivars. Data were collected from 617 individual trees, over 5 years. Species richness and community composition were significantly influenced by both orchard and cultivar. Differences among orchards explained 16% of the variation in bryophyte community data, while cultivar explained 4%. For 13 of the 41 bryophyte species recorded, apple cultivar was an important factor in explaining their distribution. While the effects of cultivar were small, we were able to detect them at multiple levels of analysis. We provide evidence that extended phenotypes act in productive as well as natural systems. With issues of food security ranking high on the international agenda, it is important to understand the impact of production regimes on associated biodiversity. Our results can inform mitigation of this potential conflict.
Highly Sensitive Amperometric Sensor for Eugenol Quantification Based on CeO2 Nanoparticles and Surfactants
Authors: Ziyatdinova Guzel , Ziganshina Endzhe , Romashkina Svetlana , Budnikov Herman 
Published: January 2017

AbstractAmperometric sensor for eugenol based on glassy carbon electrode (GCE) modified with CeO2 nanoparticles dispersed in surfactant was fabricated. The effect of surfactant nature (sodium dodecylsulfate, cetylpyridinium bromide (CPB) and Brij® 35) on eugenol voltammetric behaviour was tested. In comparison to CeO2‐H2O/GCE, CeO2‐CPB/GCE showed 2.8‐fold increased current and 70 mV cathodic shift of potential in the diffusion‐controlled irreversible electrooxidation. The electrodes were characterized with SEM and EIS. CeO2‐CPB/GCE showed significantly lower charge transfer resistance (2.6±0.3 kΩ vs. 20±1 kΩ for CeO2‐H2O/GCE and 173±9 kΩ for GCE). Under conditions of DPV, the sensor linear dynamic range is 0.075‐75.0 μM of eugenol with the limits of detection (LOD) and quantification (LOQ) of 19.1 and 63.8 nM, respectively. The sensor exhibited high sensitivity, selectivity, good reproducibility and fast response and was applied for the real samples analysis (essential oils and clove spices). The results obtained correspond well to the data of spectrophotometric method.
Serpentinite Carbonation Process Routes using Ammonium Sulfate and Integration in Industry
Authors: Zevenhoven Ron , Slotte Martin , Koivisto Evelina , Erlund Rickard 
Published: January 2017

AbstractVast resources of serpenitinite rock available worldwide are capable of binding CO2 amounts that diminish the capacity of methods based on geological storage of CO2. R&D has been ongoing in Finland for many years on developing large‐scale application of process routes for serpentinite carbonation. Several routes have been assessed in the laboratory, in all cases using ammonium salts to extract magnesium from rock followed by carbonation either in a gas/solid reactor at elevated temperatures and pressures or in an aqueous solution at ambient conditions. The choice for either route is motivated by the CO2‐producing source, (waste) heat availability, the magnesium (hydro‐)carbonate product aimed at, and a preference for energy efficiency or simplicity. Rocks from several locations have been analysed. A special issue is the recovery of the ammonium flux salt, typically from an aqueous solution. As for application, several industry sectors are considered, such as a (natural gas fired) power plant, a lime kiln, or iron‐ and steelmaking, applying mineral carbonation (MC) to blast furnace top gas. The analysis includes life cycle assessment (LCA). Finally, the use of magnesium (hydro‐)carbonates for heat storage is addressed.
BRCA1 alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA‐like breast cancers treated with neoadjuvant chemotherapy
Authors: Takada Mamoru , Nagai Shigenori , Haruta Masayuki , Sugino Ryuichi P. , Tozuka Katsunori , Takei Hiroyuki , Ohkubo Fumie , Inoue Kenichi , Kurosumi Masafumi , Miyazaki Masaru , Sato‐Otsubo Aiko , Sato Yusuke , Ogawa Seishi , Kaneko Yasuhiko 
Published: January 2017

AbstractThe BRCA‐like phenotype is a feature that some sporadic breast cancers share with those occurring in BRCA1 or BRCA2 mutation carriers. As tumors with the phenotype have defects in the DNA damage response pathway, which may increase sensitivity to drugs such as DNA cross‐linking agents and PARP inhibitors, a method to identify this phenotype is important. The prediction of chemoresistance, which frequently develops in these tumors, is also crucial for improving therapy. We examined genomic aberrations and BRCA1 promoter methylation in tumors of 73 breast cancer (20 HR−/HER2− and 53 HR+/HER2−) patients, who received neoadjuvant chemotherapy with anthracycline, cyclophosphamide, and taxane, using SNP array CGH and quantitative PCR. The methylation and/or loss or uniparental disomy (UPD) of BRCA1 (BRCA1 alterations) and the loss or UPD of BRCA2 (BRCA2 alterations) were detected in 27 (37%) and 21 (29%), respectively, of the 73 tumors. Tumors with BRCA1 or BRCA2 alterations were associated with a higher number of genomic aberrations (P < 0.001 and P < 0.001) and higher percentage of TP53 alterations (P < 0.001 and P < 0.001) than those without. Overall survival (OS) rates were similar between patients with or without BRCA1 or BRCA2 alterations. However, when 27 patients with BRCA1‐altered tumors were classified into those with or without the loss or UPD of PALB2, PAGR1, RAD51B, FANCM, MLL4, or ERCC1/2 in tumors, patients with additional defects in DNA damage response genes had worse OS (P = 0.037, 0.045, 0.038, 0.044, 0.041, or 0.019) than those without. These defects may confer chemoresistance and predict poor outcomes in patients with BRCA1‐altered breast cancer.
Bedrock geology controls on catchment storage, mixing, and release: A comparative analysis of 16 nested catchments
Authors: Pfister Laurent , Martínez‐Carreras Núria , Hissler Christophe , Klaus Julian , Carrer Gwenael E. , Stewart Mike K. , McDonnell Jeffrey J. 
Published: January 2017

AbstractThe bedrock controls on catchment mixing, storage, and release have been actively studied in recent years. However, it has been difficult to find neighbouring catchments with sufficiently different and clean expressions of geology to do comparative analysis. Here, we present new data for 16 nested catchments (0.45 to 410 km2) in the Alzette River basin (Luxembourg) that span a range of clean and mixed expressions of schists, phyllites, sandstones, and quartzites to quantify the relationships between bedrock permeability and metrics of water storage and release. We examined 9 years' worth of precipitation and discharge data, and 6 years of fortnightly stable isotope data in streamflow, to explore how bedrock permeability controls (a) streamflow regime metrics, (b) catchment storage, and (c) isotope response and catchment mean transit time (MTT). We used annual and winter precipitation–run‐off ratios, as well as average summer and winter precipitation–run‐off ratios to characterise the streamflow regime in our 16 study catchments. Catchment storage was then used as a metric for catchment comparison. Water mixing potential of 11 catchments was quantified via the standard deviation in streamflow δD (σδD) and the amplitude ratio (AS/AP) of annual cycles of δ18O in streamflow and precipitation. Catchment MTT values were estimated via both stable isotope signature damping and hydraulic turnover calculations. In our 16 nested catchments, the variance in ratios of summer versus winter average run‐off was best explained by bedrock permeability. Whereas active storage (defined here as a measure of the observed maximum interannual variability in catchment storage) ranged from 107 to 373 mm, total catchment storage (defined as the maximum catchment storage connected to the stream network) extended up to ~1700 mm (±200 mm). Catchment bedrock permeability was strongly correlated with mixing proxies of σδD in streamflow and δ18O AS/AP ratios. Catchment MTT values ranged from 0.5 to 2 years, based on stable isotope signature damping, and from 0.5 to 10 years, based on hydraulic turnover.
Current applications and limitations of surgical treatments for movement disorders
Authors: Krack Paul , Martinez‐Fernandez Raul , del Alamo Marta , Obeso Jose A. 
Published: January 2017

ABSTRACTFunctional neurosurgery for the treatment of both psychiatric and neurological disorders has been performed regularly since the 1940s. However, misuse in the early days and the appearance of effective medical treatments, such as levodopa and neuroleptic drugs, greatly reduced surgical approaches over several decades. The development of a comprehensive model of basal ganglia pathophysiology in the 1990s facilitated the resurgence of functional neurosurgery, mainly for the treatment of levodopa‐related motor complications in Parkinson's disease. This led first to the re‐emergence of posteroventral pallidotomy and subsequently to deep brain stimulation. Thirty years on from this turning point, we find ourselves looking at a new scenario. Although deep brain stimulation is accepted worldwide and technical advances continue to improve this therapy, new questions and challenges such as long‐term benefits and optimal targeting have emerged. In addition, new nonincisional tools used to perform ablative treatments, such as high‐intensity focused ultrasound and gamma‐knife, are challenging classical reluctance to therapeutic lesioning, and it remains to be determined how these approaches will fit into the array of movement disorder treatments. This review discusses the current clinical state of the art of functional neurosurgery in the treatment of Parkinson's disease, tremor, and dystonia. © 2017 International Parkinson and Movement Disorder Society
A novel double balanced image‐rejected mixer for ultra‐wide band communication systems
Authors: Cao Xin , Tang Zongxi , Wang Fei 
Published: January 2017

ABSTRACTIn this article, a novel double balanced image‐rejected mixer is proposed. To increase image‐rejection, a novel power divider based on quarter‐wavelength resonators, a pair of radial‐stub‐loaded coupled line filters, and a 3 dB RF quadrature microstrip/slot line coupler are employed in our design. The measurement is implemented using the Rohde & Schwarz four‐port vector analyzer. The measured results show that, the conversion loss is less than 17 dB with the image rejection over 14 dB within the operating band from 3.1 GHz to 10.6 GHz. Good performances have been achieved. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:578–584, 2017
Optical‐wireless integration of W‐band wireless and free‐space optical links
Authors: Han Xifeng , Chen Long , Li Xinying , Xiao Jiangnan , Yu Jianjun 
Published: January 2017

ABSTRACTWe propose and experimentally demonstrate a novel optical‐wireless architecture for the integration of W‐band wireless and free‐space optical (FSO) links with intensity modulation and direct detection (IM/DD). This architecture can be used to increase the data rate, capacity, and flexibility. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:561–563, 2017
A novel power efficient asynchronous time difference of arrival indoor localization system using CC1101 radio transceivers
Authors: Nawaz Haq , Bozkurt Ayhan , Tekin Ibrahim 
Published: January 2017

ABSTRACTThis paper presents a novel 434MHz asynchronous time difference of arrival (A‐TDOA) Indoor Localization System (ILS) using three CC1101 ultra low power radio transceivers from Texas Instruments as asynchronous measuring receivers for time difference of arrival estimation. The three deployed TDOA measuring units are not required to be precisely synchronized in contrast to conventional TDOA localization systems where stringent time synchronization is required between measuring units. Time synchronization is achieved by using a reference transmitter to record the time offset in two TDOA measurements. Actual TDOA measurements are obtained by compensating the time difference measurements for real transmitter using time offsets caused by asynchronous receivers. The implemented system demodulates the obtained time difference pulses to mitigate the clock jitter effect and provides voltage levels corresponding to time differences which are mapped to distance differences. The performance of implemented ILS is evaluated using two sets of real time indoor measurements to estimate the position of mobile transmit node in two dimensional space. The positioning accuracy of implemented system is better than 1.8m along with telemetry data reception capability and low DC power consumption. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:550–555, 2017
Quad‐band planar monopole antenna with bent ground plane for WLAN and WiMAX applications
Authors: Ahmad Muhammad Sajjad , Kim Che Young 
Published: January 2017

ABSTRACTA quad‐band planar monopole antenna that consists of a bent ground plane, pair of parasitic patches, and a radiating patch excited by a coaxial feeding is proposed. The proposed antenna design has ability to maintain its resonant frequencies in standalone mode, extended planar ground plane mode, and even when attached to a metal case. This antenna can be used for multiple applications that operate at WLAN 2.4/5.2/5.8 GHz, WiMAX 3.5/5.5 GHz and 4.5 GHz, which is used for point‐to‐point microwave and telemetry applications. The simulated and measured results of the antenna are in agreement with industry standards. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:588–593, 2017
Real‐time 2.5 Gbit/s ultra‐wideband transmission using a Schottky diode‐based envelope detector
Authors: Rommel Simon , Cimoli Bruno , Silva Valdecasa Guillermo , Jensen Jesper B. , Johansen Tom Keinicke , Vegas Olmos Juan J. , Tafur Monroy Idelfonso 
Published: January 2017

ABSTRACTAn experimental demonstration of 2.5 Gbit/s real‐time ultra‐wideband transmission is presented, using a Schottky diode‐based envelope detector fabricated ad‐hoc using microstrip technology on a Rogers6002 substrate and surface‐mount components. Real‐time transmission with a BER below FEC threshold is achieved for 20 cm of wireless transmission at 2.5 Gbit/s and 50 cm at 1.25 Gbit/s. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:606–609, 2017
Wideband antenna for 4G MIMO applications
Authors: Kenny Caitlin , Odendaal Johann W. , Joubert Johan 
Published: January 2017

ABSTRACTA small, wideband, multiple‐input‐multiple‐output antenna is presented for 4G long term evolution (LTE) applications. The proposed antenna consists of a vertically polarized wideband stepped slot, as well as a horizontally polarized narrowband, uniform slot, integrated on a single substrate and fed by two ports. A prototype of the proposed antenna was designed, fabricated, and measured. The stepped slot antenna achieves an enhanced bandwidth of 122% from 0.77 GHz to 3.12 GHz, covering the 2G, 3G, and 4G bands. The narrowband slot achieves a bandwidth of 35% from 2.11 GHz to 3.01 GHz, covering the 4G band frequencies only. The isolation between the two slots is greater than 21 dB over the entire band of interest. The radiation pattern of the wideband slot in the horizontal plane is omnidirectional in nature while the narrowband slot exhibits a bidirectional radiation pattern in the horizontal plane. The proposed antenna is suitable for indoor, ceiling‐mount, microcell 4G LTE applications. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:601–604, 2017
Miniaturized implantable antenna integrated with split resonate rings for wireless power transfer and data telemetry
Authors: Zhang Huiying , Li Long , Liu Changrong , Guo Yong‐Xin , Wu Sirao 
Published: January 2017

ABSTRACTIn this article, a new miniaturized implantable antenna (MIA) is proposed for biomedical applications. The antenna is composed of a loop integrated with split resonate rings (SRRs), which produces two resonant modes to make the antenna operate at both Medical Implantable Communications Service (MICS) 402–405 MHz and Industrial, Scientific, and Medical (ISM) 2.40–2.48 GHz bands. Compared to the traditional dual‐band implantable antennas, the proposed MIA has a few advantages: it is small, easy to operate, and has a wide bandwidth. Most importantly, −8 dB coupling strength can be obtained when the distance between the proposed antenna and the external antenna is 5 mm. The vitro test in a minced‐pork environment was performed to demonstrate the reliability of the proposed antenna in the real implantation. The size of the proposed antenna is 152.4 mm3 (10 mm × 12 mm × 1.27 mm). The simulated and measured impedance bandwidths are 43.4% and 33.9% at the MICS band, 64.2% and 58.7% at the ISM band, respectively. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:710–714, 2017
The impact of telephonic wellness coaching on weight loss: A “Natural Experiments for Translation in Diabetes (NEXT‐D)” study
Authors: Schmittdiel Julie A. , Adams Sara R. , Goler Nancy , Sanna Rashel S. , Boccio Mindy , Bellamy David J. , Brown Susan D. , Neugebauer Romain S. , Ferrara Assiamira 
Published: January 2017

ObjectiveTo evaluate the impact of a population‐based telephonic wellness coaching program on weight loss.MethodsIndividual‐level segmented regression analysis of interrupted time series data comparing the BMI trajectories in the 12 months before versus the 12 months after initiating coaching among a cohort of Kaiser Permanente Northern California members (n = 954) participating in The Permanente Medical Group Wellness Coaching program in 2011. The control group was a 20:1 propensity‐score matched control group (n = 19,080) matched with coaching participants based on baseline demographic and clinical characteristics.ResultsWellness coaching participants had a significant upward trend in BMI in the 12 months before their first wellness coaching session and a significant downward trend in BMI in the 12 months after their first session equivalent to a clinically significant reduction of greater than one unit of baseline BMI (P < 0.01 for both). The control group did not have statistically significant decreases in BMI during the post‐period.ConclusionsWellness coaching has a positive impact on BMI reduction that is both statistically and clinically significant. Future research and quality improvement efforts should focus on disseminating wellness coaching for weight loss in patients with diabetes and those at risk for developing the disease.
Nuchal translucency measurement in the era of prenatal screening for aneuploidy using cell free (cf)DNA
Authors: O'Brien Barbara M. , Halliday Jacquelyn , Lambert‐Messerlian Geralyn , Eklund Elizabeth E. , Kloza Edward , Palomaki Glenn E. 
Published: January 2017

What's already known about this topic?

Nuchal translucency measurement in the first trimester is a proven marker to assess risk of common aneuploidies.
Prenatal screening using cfDNA performs better than any combined ultrasound and serum marker test.
The value of an NT scan in women having screening by cfDNA is questionable.

What does this study add?

A positive NT ultrasound scan did not add to the cases of aneuploidy that were detected by cfDNA screening.