bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПОШИРЕНIСТЬ БЕССИМПТОМНО ГIПЕРУРИКЕМII СЕРЕД ХВОРИХ З IШЕМIЧНОЮ ХВОРОБОЮ
Authors: Kadyrova F. , Nasyrova Z. , Tashkenbaeva E. , Togaev D. 
Published: July 2017

Резюме Нами обстежено 206 хворих зi стабiльною стенокардiєю напруги, зних жiнок 90(43,7%) чоловiкiв 116(56,3%) середнiй вiк становив 59,5±11,1 року. За результатами дослiдження у 44% хворих на ІХС виявлена позитивна кореляцiйний зв̉ язок з основними компонентами метаболiчного синдрому (МС), що подтверждает про роль БГУ в розвиток кардiоваскулярного i вимагає превентивноi корекцii урикозуричними препаратами.
Оцінка якості життя у прооперованих хворих з приводу колоректального раку, ускладненого обтураційною кишковою непрохідністю з різними типами завершення оперативного втручання
Authors: Grytsenko S. Y. 
Published: July 2017

Мета дослідження – Провести оцінку та порівняння якості життя хворих на коло ректальний рак, ускладнений обтураційною кишковою непрохідністю з різними типами завершення оперативного втручання.Матеріали і методи. Проаналізовано безпосередні результати якості життя 55 хворих на колоректальний рак, ускладнений обтураційною кишковою непрохідністю з різними типами завершення оперативного втручання.Результати досліджень та їх обговорення. Практично всі пацієнти, охоплені нашим дослідженням, у перші 2 місяці після операції відчували погіршення фізичного та психоемоційного стану у зв’язку з пристосуванням до користування стомою, однак у терміни 6 місяців та 1 рік пацієнти першої групи відмітили покращення свого стану.
Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease–Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo
Authors: Hara Tetsuya , Monguchi Tomoko , Iwamoto Noriko , Akashi Masaya , Mori Kenta , Oshita Toshihiko , Okano Mitsumasa , Toh Ryuji , Irino Yasuhiro , Shinohara Masakazu , Yamashita Yui , Shioi Go , Furuse Mikio , Ishida Tatsuro , Hirata Ken-ichi 
Published: July 2017

Objective—
Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell–cell junctions in endothelial cells, we hypothesized and tested whether JCAD regulates angiogenic processes in vitro and in vivo.

Approach and Results—

Cell culture experiments revealed impaired angiogenic ability (proliferation, migration, and cord formation) by the knockdown of JCAD with siRNA (
P
<0.05 versus control siRNA). We have generated mice lacking JCAD (mKIAA1462
−/−
) by gene-targeted deletion of JCAD to address in vivo angiogenic function. mKIAA1462
−/−
mice did not show morphological differences in development of retinal vasculature. Ex vivo aortic ring model demonstrated impaired neovascularization in aorta from mKIAA1462
−/−
mice than control wild-type mice (
P
<0.05). Tumor growth was assessed by monitoring tumor volume after the subcutaneous injection of melanoma, LLC (Lewis lung carcinoma), and E0771 cells into the mice. mKIAA1462
−/−
mice exhibited significantly smaller tumor volume compared with wild-type mice (
P
<0.001). Histological assessment of the tumor exhibited less smooth muscle actin–positive neovascularization determined by CD31-positive vascular structure in tumor of mKIAA1462
−/−
mice than wild-type mice, indicating that knockdown of JCAD inhibited the vascular maturation in pathological angiogenic process.

Conclusions—
These in vitro and in vivo studies suggest that JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth.
Automated Quantification of Low-Amplitude Abnormal QRS Peaks From High-Resolution ECG Recordings Predicts Arrhythmic Events in Patients With Cardiomyopathy
Authors: Das Moloy , Suszko Adrian M. , Nayyar Sachin , Viswanathan Karthik , Spears Danna A. , Tomlinson George , Pinter Arnold , Crystal Eugene , Dalvi Rupin , Krishnan Sridhar , Chauhan Vijay S. 
Published: July 2017

Background—
Cardiomyopathy patients are at risk of sudden death, typically from scar-related abnormalities of electrical activation that promote ventricular tachyarrhythmias. Abnormal intra-QRS peaks may provide a measure of altered activation. We hypothesized that quantification of such QRS peaks (QRSp) in high-resolution ECGs would predict arrhythmic events in implantable cardioverter–defibrillator (ICD)–eligible cardiomyopathy patients.

Methods and Results—

Ninety-nine patients with ischemic or non-ischemic dilated cardiomyopathy undergoing prophylactic ICD implantation were prospectively enrolled (age 62±11 years, left ventricular ejection fraction 27±7%). High-resolution (1024 Hz) digital 12-lead ECGs were recorded during intrinsic rhythm. QRSp was quantified for each precordial lead as the total number of low-amplitude deflections that deviated from their respective naive QRS template. The primary end point of arrhythmic events was defined as appropriate ICD therapy or sustained ventricular tachyarrhythmias. After a median follow-up of 24 (15–43) months, 20 (20%) patients had arrhythmic events. Both QRSp and QRS duration were greater in those with arrhythmic events (both
P
<0.001) and this was consistent for QRSp for both cardiomyopathy types. In a multivariable Cox regression model that included age, left ventricular ejection fraction, QRS duration, and QRSp, only QRSp was an independent predictor of arrhythmic events (hazard ratio, 2.1;
P
<0.001). Receiver operating characteristic analysis revealed that a QRSp ≥2.25 identified arrhythmic events with greater sensitivity (100% versus 70%,
P
<0.05) and negative predictive value (100% versus 89%,
P
<0.05) than QRS duration ≥120 ms.

Conclusions—
QRSp measured from high-resolution digital 12-lead ECGs independently predicts ventricular tachyarrhythmias in ICD-eligible cardiomyopathy patients. This novel QRS morphology index has the potential to improve sudden death risk stratification and patient selection for prophylactic ICD therapy.
Cerebral Microbleeds in Murine Amyloid Angiopathy
Authors: Marinescu Marilena , Sun Li , Fatar Marc , Neubauer Andreas , Schad Lothar , van Ryn Joanne , Lehmann Lorenz , Veltkamp Roland 
Published: July 2017

Background and Purpose—
Cerebral microbleeds (CMBs) predispose patients to intracerebral hemorrhage. Preclinical models to examine the effects of antithrombotic treatments on the development of clinically overt intracerebral hemorrhage are needed. We examined the natural course of CMB development and the effects of long-term anticoagulation with warfarin or dabigatran on cerebral micro- and macrohemorrhage in mice overexpressing the APP23 (amyloid precursor protein).

Methods—
Repeated susceptibility-weighted magnetic resonance imaging was performed in APP23 mice at the age of 18 and 21 months, respectively. After establishing stable long-term anticoagulation effects of warfarin and dabigatran on number and total volume of CMBs, the outcome parameters were compared with nonanticoagulated control.

Results—

CMBs were equally located in lobar and deep brain regions, and number and total volume of CMBs increased over time. Anticoagulation with either warfarin or dabigatran did not increase CMBs in APP23 significantly. Mice treated with warfarin numerically had a higher mortality (nonanticoagulated: 31%; dabigatran: 35% versus warfarin: 55%;
P
=0.21). In postmortem brains of prematurely dying animals warfarin caused significantly more frequently large intracerebral hemorrhage than control and dabigatran.

Conclusions—
Anticoagulation with warfarin or dabigatran for 3 to 4 months does not promote the formation of CMBs in aged APP23 mice. Nevertheless, warfarin but not dabigatran is associated with a higher risk of extensive intracerebral hemorrhage, suggesting that this model may allow preclinical safety evaluation of antithrombotic therapies.
How Do You See Me? The Neural Basis of Motivated Meta-perception
Authors: Flagan Taru , Mumford Jeanette A. , Beer Jennifer S. 
Published: July 2017

AbstractWe cannot see the minds of others, yet people often spontaneously interpret how they are viewed by other people (i.e., meta-perceptions) and often in a self-flattering manner. Very little is known about the neural associations of meta-perceptions, but a likely candidate is the ventromedial pFC (VMPFC). VMPFC has been associated with both self- and other-perception as well as motivated self-perception. Does this function extend to meta-perceptions? The current study examined neural activity while participants made meta-perceptive interpretations in various social scenarios. A drift-diffusion model was used to test whether the VMPFC is associated with two processes involved in interpreting meta-perceptions in a self-flattering manner: the extent to which the interpretation process involves the preferential accumulation of evidence in favor of a self-flattering interpretation versus the extent to which the interpretation process begins with an expectation that favors a self-flattering outcome. Increased VMPFC activity was associated with the extent to which people preferentially accumulate information when interpreting meta-perceptions under ambiguous conditions and marginally associated with self-flattering meta-perceptions. Together, the present findings illuminate the neural underpinnings of a social cognitive process that has received little attention to date: how we make meaning of others' minds when we think those minds are pointed at us.
Imaginative Reinforcement Learning: Computational Principles and Neural Mechanisms
Authors: Gershman Samuel J. , Zhou Jimmy , Kommers Cody 
Published: July 2017

Abstract
Imagination enables us not only to transcend reality but also to learn about it. In the context of reinforcement learning, an agent can rationally update its value estimates by simulating an internal model of the environment, provided that the model is accurate. In a series of sequential decision-making experiments, we investigated the impact of imaginative simulation on subsequent decisions. We found that imagination can cause people to pursue imagined paths, even when these paths are suboptimal. This bias is systematically related to participants' optimism about how much reward they expect to receive along imagined paths; providing feedback strongly attenuates the effect. The imagination effect can be captured by a reinforcement learning model that includes a bonus added onto imagined rewards. Using fMRI, we show that a network of regions associated with valuation is predictive of the imagination effect. These results suggest that imagination, although a powerful tool for learning, is also susceptible to motivational biases.
Computation of Density for A Linear Combination of –Generalized Normal Random Variables
Authors: Lee Ru-Ying , Goodman I. R. 
Published: July 2017

A computational procedure is presented for the approximation of the density of a linear combination of univariate -generalized normal random variables. (The -generalized normal random variable generalizes the ordinary normal one by replacing the power two in the exponent of the density by an arbitrary positive number.) The procedure applies a truncated form of the Fourier Inversion Theorem to the power series expansion of the characteristic function of a -generalized normal random variable. Because of the unimodal nature of -generalized normal characteristic functions for ⩽ 2 and the oscillatory nature for > 2, much of the computational procedure divides into two corresponding parts. Complete error analysis and accuracy control in all computations are also presented.
Multivariate Rank Analysis of Covariance Under Exchangeability of the Primary Variates
Authors: Mukherjee Indranil 
Published: July 2017

The paper considers the usual Rank Analysis of Convariance (RANOCOVA) problem, but under the known permutation symmetry of the primary response variates. The setup crops up in many biometric (e.g. ophthalmological studies) as well as engineering applications where the units on which the responses are measured cannot be taken as independent, but may well be assumed to have exchangeable multivariate distributions for proper natural groupings of the responses. In such cases the conventional nonparametric RANOCOVA methods are eminently applicable, but, the present paper proposes a method by which the efficiency of the inferential processes can be increased substantially. The paper also reports the results of a limited simulation experiment performed to compare the proposed method to the conventional RANOCOVA procedure (cf. Sen, 1984). AMS 1991 Subject classification : 62G 10.
Estimation of the Parameters of the Uniform Distribution Over [kθ, (k+ 1)θ]
Authors: Thomas P. Yageen 
Published: July 2017

From the available literature on estimation of the parameters of the uniform distribution over [ kθ, kθ + θ], we find the necessity to construct improved estimators of the parameter θ when k is known. In this paper a new estimator of θ is proposed when k is known and its performance is compared with best linear unbiased estimator of θ based on two extreme observations. A MS Subject Classification: Primary: 62H12; Secondary: 62G30, 62B05.
The applicability of organomodified nanoclays as new fillers for mechanical reinforcement of dental composites
Authors: Menezes Lívia Rodrigues , Silva Emerson Oliveira da , Rocha Anne Caroline da Silva , Oliveira Dayane Carvalho Ramos Salles de , Campos Paulo Ricardo de Barros 
Published: July 2017

Objectives This study reports the evaluation of changes in crosslink structure and mechanical properties of dental microhybrid composite reinforced with clays when compared to silica nanofillers, which are already extensively used for this application. Materials and methods A standardized resin matrix with a glycerolate dimethacrylate, triethylene glycol dimethacrylate, and urethane dimethacrylate copolymers associated with a camphorquinone photoinitiator system was blended with 75 wt% filler content. As fillers, two organically modified clays (hydrophilic silica and organomodified silica) and a boron-aluminum-silicate glass with 4 µm were used to obtain nanohybrid nanocomposites. The samples were prepared by light curing and were evaluated by measuring flexural strength, elasticity modulus, hardness, tensile resistance, and crosslinking. Results The mechanical test results indicated that the system with 2.5% clay was better dispersed in the system, while the highest concentrations caused agglomeration of these clays. On the other hand, the silicas showed gradual gain in properties. The increase in concentration of all nanofillers reduced the crosslinking ability of the systems. This behavior can be explained because the clay’s presence makes the reaction medium more viscous or because the fillers act as points of light absorption and scattering.
Pulmonary Vascular Occlusive Disease Presenting as Sudden Death
Authors: Bolster M. A. , Hogan J. , Bredin C.P. 
Published: July 2017

We report a case of pulmonary vascular occlusive disease (also termed pulmonary veno occlusive disease) which caused the sudden death of an eleven-year-old girl. The post-mortem findings are described and the current theories of aetiology and pathogenesis of this unusual condition are reviewed. The clinical picture is characterized by pulmonary hypertension with marked increase of pulmonary arterial pressure but often normal or only slightly elevated wedge pressure. The pulmonary vasculature, especially the veins, show progressive fibrotic occlusion. The aetiology is unknown but an infective cause is considered most likely. Definitive diagnosis usually depends on an open lung biopsy or, more commonly, autopsy examination.
Genetic and Neurodevelopmental Influences in Autistic Disorder
Authors: Nicolson Rob , Szatmari Peter 
Published: July 2017

Objective: In the past, autism was considered to be largely psychogenic. However, research in the last 2 decades indicates that autism is largely caused by genetic factors that lead to abnormal brain development. This article reviews research into the genetic and neurodevelopmental factors underlying autism. Methods: We review the findings from genetic and brain-imaging studies of autism over the past 15 years and synthesize these findings as a guide for future research. Results: Genome scans and association studies have suggested potential genomic regions and genes, respectively, that may be involved in the etiology of autism, and there have been some replications of these results. Similarly, the findings that brain volume is exaggerated in autism and corpus callosum size is reduced have also been independently replicated. Unfortunately, studies of other subcortical structures remain inconclusive or contradictory. Conclusions: Overwhelming evidence now supports a neurobiological basis for autism. However, further refinements will be needed to guide future studies, particularly to identify the most informative phenotypes to investigate. Additionally, studies examining the role of genetic factors in the brain abnormalities underlying autism will likely lead to further findings that will enhance our understanding of autism's causes.
Adult Antisocial Behaviour without Conduct Disorder: Demographic Characteristics and Risk for Cooccurring Psychopathology
Authors: Marmorstein Naomi R 
Published: July 2017

Objective: Several studies note people who demonstrate adult antisocial behaviour (AAB) in the absence of conduct disorder (CD) before age 15 years. Perhaps because they do not meet diagnostic criteria for antisocial personality disorder (ASPD), this group of people exhibiting late-onset AAB has been underrecognized and understudied. Thus the goal of this study was to examine the demographic features and patterns of cooccurring psychopathology of people exhibiting late-onset antisocial behaviour (AB; AAB but not CD), compared with people suffering from ASPD (CD and AAB), people suffering from CD but not AAB, and members of a nonantisocial control group. Method: This study used the population-based sample of the National Comorbidity Survey (NCS). The demographic features examined were sex, percentage living in poverty, annual income, and years of formal education. The possibly cooccurring diagnoses examined were alcohol abuse and dependence, drug abuse and dependence, major depressive disorder, dysthymia, generalized anxiety disorder, social phobia, simple phobia, panic disorder, agoraphobia, and posttraumatic stress disorder. Results: About 2.3% of participants exhibited AAB but not CD. These individuals had patterns of demographic characteristics and cooccurring psychiatric disorders quite similar to those of people diagnosed with full ASPD. Conclusion: Individuals who demonstrate this pattern of late-onset AB are at levels of risk comparable to those of individuals suffering from ASPD; therefore, they are equally in need of research and clinical attention.
Sexual Function during Bupropion or Paroxetine Treatment of Major Depressive Disorder
Authors: Kennedy Sidney H , Fulton Kari A , Bagby R Michael , Greene Andrea L , Cohen Nicole L , Rafi-Tari Shahryar 
Published: July 2017

Objective: The primary objective was to evaluate sexual function (SF) separately in men and women with major depressive disorder (MDD) before and during treatment with bupropion sustained release (SR) or paroxetine. The secondary objectives involved a comparative evaluation of the Sex Effects Scale (Sex FX) and the Investigator-Rated Sexual Desire and Functioning Scale (IRSD-F), as well as a comparison of antidepressant outcomes and an examination of the relation between level of depression and SF over time. Method: There were 141 patients (68 women and 73 men) who met DSM-IV criteria for a current major depressive episode. They were randomly assigned to receive bupropion SR (150 to 300 mg daily) or paroxetine (20 to 40 mg daily) under double-blind trial conditions. Patients were assessed at baseline and at 2, 4, 6, and 8 weeks with the 17-item Hamilton Depression Rating Scale (HDRS17), Sex FX, and IRSD-F. Results: Prior to treatment, women reported significantly lower SF on both the Sex FX and IRSD-F scales, compared with men. During treatment, there were no significant drug differences on measures of SF over time for women; however, men who were treated with paroxetine reported a worsening of SF, whereas bupropion SR did not significantly alter SF. Both bupropion SR and paroxetine produced clinically and statistically significant reductions in HDRS17 scores as well as comparable rates of response and remission. There was a statistically significant correlation between the 2 measures of SF at all visits. There was also a significant inverse relation between depression and SF in women, but not in men, irrespective of drug. Conclusion: According to the Sex FX scale, a significant difference in antidepressant-related sexual dysfunction was detected in men, but not women, during treatment with bupropion SR or paroxetine.
Association Study of Astrocyte-Derived Protein S100B Gene Polymorphisms with Major Depressive Disorder in Chinese People
Authors: Yang Kun , Xie Guang-Rong , Hu Yi-Qiu , Mao Fu-Qiang , Su Lin-Yan 
Published: July 2017

Objective: Astroglial-derived protein S100B is known to play important roles in axonal growth, neural plasticity, and energy regulation. Disturbance of these neurodevelopmental processes is proposed as one possible etiology for mood disorder. Therefore, we performed a genetic analysis of S100B in patients with major depressive disorder (MDD). Method: The polymorphisms of S100B were determined by polymerase chain reaction–restriction fragment length polymorphism in patients ( n = 152) with MDD and healthy control subjects ( n = 150). The genotypic and allelic distributions of 2 variants were analyzed in Chinese patients. Results: Two single nucleotide polymorphisms did not display significant associations with MDD. However, there were significant differences in age of onset in 3 genotypes of S100B rs9722. Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects ( P < 0.05). Conclusions: Our findings did not suggest association of S100B gene polymorphisms in patients with MDD in China. We found there were differences in depressive episodes among different genotypes of S100B gene.