bluuebunny/crossref_metadata_2025_split huggingface dataset:
A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor
Authors: Abaffy Tatjana , Bain James R. , Muehlbauer Michael J. , Spasojevic Ivan , Lodha Shweta , Bruguera Elisa , O’Neal Sara K. , Kim So Young , Matsunami Hiroaki 
Published: January 2018

AbstractOlfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer but its function is not well understood. Throughin silicoandin vitroanalyses, we identified 24 agonists and 1 antagonist for this receptor. We detected that agonist 19-hydroxyandrostenedione, a product of the aromatase reaction, is endogenously produced upon receptor activation. We characterized the effects of receptor activation on metabolism using a prostate cancer cell line and demonstrated decreased intracellular anabolic signals and cell viability, induction of cell cycle arrest, and increased expression of neuronal markers. Furthermore, upregulation of neuron-specific enolase by agonist treatment was abolished in OR51E2-KO cells. The results of our study suggest that OR51E2 activation results in neuroendocrine trans-differentiation. These findings reveal a new role for OR51E2 and establish this G-protein coupled receptor as a novel therapeutic target in the treatment of prostate cancer.SignificanceProstate cancer is the second most common cancer in men. Most deaths from prostate cancer are due to the progression of localized disease into metastatic, castration-resistant prostate cancer characterized by increased number of neuroendocrine-like cells. These neuroendocrine-like cells are non-proliferating, terminally differentiated cells. Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer, and its expression correlates with disease progression. Here, we identify and validate novel endogenous ligands for this receptor. We show that activation of OR51E2 by newly-discovered prostate cancer-relevant agonists facilitates cellular transformation, resulting in neuroendocrine trans-differentiation, a characteristic phenotype of castrate resistant prostate cancer. Our results establish this G-protein coupled receptor as a novel and therapeutic target for castration-resistant prostate cancer.HighlightsDiscovery of novel agonists for olfactory receptor OR51E2/PSGR highly relevant to prostate cancer pathologyActivation of OR51E2 receptor by agonistN-acetyl-N-formyl-5-methoxykynurenamine (AFMK) results in release of 19-hydroxyandrostenedione (19-OH AD) from the prostate cancer cells indicating its endogenous productionActivation of OR51E2 receptor by 19-OH AD, AFMK, and propionic acid decreases anabolic and proliferative signalsActivation of OR51E2 receptor by 19-OH AD and AFMK increases markers specific for neuroendocrine trans-differentiation (NEtD)Ablation of the OR51E2 gene in prostate cancer cells treated with agonist 19-OH AD significantly reduces neuron-specific enolase
Exploratory study of personal health information management using health literacy model
Authors: Kim Sujin , Syn Sue Yeon , Sinn Donghee 
Published: January 2018

PurposeThe purpose of this paper is to empirically test whether individuals’ internal factors (prior knowledge, resources, and capability) and environmental factors (stimuli, limitation) have any influence on the development of personal health information management (PHIM) literacy skills and which constructs are statistically associated with general health-related outcomes.Design/methodology/approachSurvey responses were collected from Amazon’s Mechanical Turk (mTurk), a crowdsourcing internet service, in December 2013. A total of 578 responses were analyzed using partial-least squares structural equation modeling technique.FindingsThe model as a whole exhibited 62.8 percent of variance in health-related outcomes. The findings suggest that prior knowledge has a direct effect on health literacy (HL) skills (H3:β=0.212,p<0.001). The PHIM stimuli (H4:β=0.475,p<0.001) have a direct impact on HL skills, and they have an indirect effect on the comprehension of stimuli (H6:β=0.526,p<0.001) through the mediator of stimuli and the knowledge variable.Research limitations/implicationsOne possible limitation of this study is that the study may include a highly technology literate group, as survey respondents were recruited from the online service mTurk.Practical implicationsThe study poses implications for further research and practice. This research was an exploratory work for further model development so future studies should investigate deeper into real personal health record (PHR) user groups (e.g. patients and caregivers). For example, studies by White and Horvitz (2009a, b) conducted real-time user studies that the authors could apply to the authors’ future PHR studies. Since the findings cannot be generalizable to these specific groups, similar research may be conducted. Using caregiver groups of PHR users in comparison to patient groups could determine the similarities and differences of their PHIM activities and related outcomes for optimal design of self-care management.Social implicationsFurther, it is suggested to conduct large scale, real-time-based studies using a PHR transaction log analysis to achieve conclusiveness and generalizability. Additionally, future studies should address not only diverse real-time user groups, but also various PHR data sources and their presentation issues.Originality/valueThis study model offers an important perspective on PHIM and its causal pathway for use not only by patient educators and healthcare providers but also information providers, personal health record (PHR) system developers, and PHR users.
Collaborative information searching as learning in academic group work
Authors: Wu Dan , Liang Shaobo , Yu Wenting 
Published: January 2018

PurposeThe purpose of this paper is to explore users’ learning in the collaborative information search process when they conduct an academic task as a group.Design/methodology/approachThis paper presents a longitudinal study for a three-month period on an actual task. The participants, who were undergraduate students, needed to write a research proposal in three months to apply for funding for a research project, including a three-hour experiment.FindingsThe results show that undergraduates’ learning in the collaborative search process for academic group work included knowledge reconstruction, tuning, and assimilation. Their understanding of the topic concepts improved through the process, and their attitudes became more optimistic. Besides, the learning in the collaborative information search process also enhanced participants’ skills in communication, research, information search, and collaboration. To improve learning outcomes, professional and appropriate academic resources are required, as well as effective division of labor, positive sharing behaviors, and use of collaborative systems.Practical implicationsThe future development of collaborative information search systems should focus on the needs of academic research and support for elements such as instant communication and knowledge sharing.Originality/valueThis paper contributes to research into searching as learning by understanding undergraduates’ collaborative search behavior for writing a proposal.
Role of libraries in promoting education: a bibliometric analysis (2012-2016)
Authors: Sahu Archana , Jena Puspanjali 
Published: January 2018

Purpose
The purpose of this paper is to investigate the authorship patterns and the relationship between them based on some statistical indices for the role of libraries in promoting education at the global level.

Design/methodology/approach
The Education Resources Information Center (ERIC) database was searched for the peer-reviewed and full text available journal articles that contained specific words related to either libraries and education or libraries and e-learning in. Data were analysed based on certain statistical calculations to find out the degree of collaboration, collaborative coefficient, Shannon index, Simpson’s indices, Spearman’s coefficient and co-authorship pattern.

Findings
The criteria were met by 262 publications by 517 authors. The highest number of articles related with the role of libraries in education was published in the year 2013, and the highest numbers of articles were authored by a single author rather than multiple authors. The degree of collaboration was found to be highest in the year 2015 and 2016 with a value of 0.66, whereas the collaborative coefficient was highest in the year 2016 with a value 0.42. The Shannon’s diversity index was found to be 2.73705 with an evenness of 1.24568. The Simpson’s index, Simpson’s index of diversity and Simpson’s reciprocal index were found to be 0.299, 0.701 and 3.3444, respectively. The Spearman’s coefficient was found to be highest with a positive correlation of value 0.95 in the year 2013. Furthermore, six co-occurrences by eight authors were found.

Research limitations/implications
Only the ERIC database was chosen for the study and only articles published from the year 2012 to 2016 were included in the analysis.

Originality/value
This study will be useful for researchers to get an insight into the collaborative research patterns demonstrated by the authors in understanding the role of libraries in education using different statistical approaches.
Non-fiction: an unnaturally naturalised concept for collection development
Authors: Kelly Matthew 
Published: January 2018

Purpose
This paper aims to problematise the basis of the use of non-fiction as an explanatory category in libraries that have mandates to deliver information to civil society users to initiate debate on its ongoing value.

Design/methodology/approach
A range of literature from the fields of information science, philosophy, literary studies and the sociology of knowledge was critically surveyed to uncover reasons for the use of the non-fiction concept when librarians are dealing with documentary knowledge. A process of thematisation of relevant material was then conducted using a methodology informed by historicist and hermeneutic-phenomenological approaches to social scientific inquiry.

Findings
The extreme simplicity of the concept of non-fiction masks a complex range of factors associated with common sense understanding of life and our conceptualisation of what constitutes knowledge in civil society information environments. By restricting the nature of questions associated with knowledge and documentary knowledge the non-fiction concept contributes to a far too narrow view of how these concepts interrelate.

Practical implications
Preliminary reasons are offered for why the non-fiction concept is problematic, and an alternative discursive formation is put forward which may enable more fruitful caretaking of documentary collections in school and public libraries.

Originality/value
This paper helps to open discussion among collection management theorists and practitioners regarding how the concept of documentary knowledge can be more usefully theorised so that it is better able to support the epistemic learning and socialisation goals of libraries characterised by their civil society setting.
Funding education: developing a method of allocation for improvement
Authors: BenDavid-Hadar Iris 
Published: January 2018

PurposeResource allocation is a key policy instrument that affects the educational achievement distribution (EAD). The literature on methods of allocation is focused mainly on equity issues. The purpose of this paper is to develop a composite funding formula, which adds to the equity-based element (i.e. a needs-based element compensating for students’ low starting points), an element of rewarding improvement in schools’ educational achievement distribution (IEAD) (i.e. raising the overall level of achievement and narrowing the achievement gap).Design/methodology/approachThis formula is developed using advanced regression models as well as integrating further policy considerations. The data sets are comprised of nation-wide student-level information on longitudinal students’ achievements (8th graders of 2006, and four years later 12th graders 2010), as well as student background characteristics, and teacher profiles and school features. The Israel data serve as an interesting case study for other countries which are similarly characterized by its students’ diversity, and by its aspiration to improve its EAD and to narrow the achievement gap.FindingsResults reveal that the variance among students’ performance is mostly explained by their past performance. In addition, other background characteristics also contribute to the explained variation in students’ performance; however, a lower contribution was found, compared with that of the previous performance. Specifically, schools’ value added contributes 25 percent to the overall 50 percent of explained variance. In other words, allocating resources to schools solely with accordance to equity issues might have an adverse effect on improvement. Yet, designing a composite mechanism that integrates both equity and improvement issues might be more effective.Practical implicationsPolicy makers in other countries that strive to achieve improvement as well as equity in education might consider adjusting the technique developed in this work. The proposed technique might be adjusted based on each country’s nation-wide student-level data. The design of a research-based funding formula aimed at improvement in education as well as considering equity issues might be more effective, equitable, and efficient.Originality/valueThe main contribution of this work is the conceptual development of IEAD, as well as its measured weight in the funding formula. This work suggests an innovative method of allocation that rewards schools by allocating larger resources based on the improvement gained in the process of learning (not just on the inputs or outputs/outcomes). This research value lays in its design of a composite funding formula that takes into account, in addition to the equity component, an innovative improvement-based component. In addition to that, the value of this research lays on its policy implications. This research suggests and develops a technique for developing a research-based funding formula that might be useful for other countries aspire to improve their education.
In vivo effects of prebiotic sugar free Brazilian cerrado fruits jam
Authors: Gonzaga Driene Gomes , Pereira Rafaela Corrêa , Silva Andressa Alvarenga , Borges Soraia Vilela , Carneiro João de Deus Souza , de Sousa Raimundo Vicente , de Angelis-Pereira Michel Cardoso 
Published: January 2018

Purpose
The purpose of this research is to develop and characterize a sugar-free Brazilian mixed fruit jam, containing marolo, sweet passion fruit and soursop, enriched with polydextrose and fructooligosaccharides (FOS), and evaluate in vivo the effect of consumption of this product.

Design/methodology/approach
In total, 48 male rats were divided into six groups and fed a AIN-93M rodent diet supplemented with 10% jam enriched with different proportions of FOS and polydextrose. The effects on glycemic response, mineral utilization and fecal and histological characteristics were evaluated.

Findings
The addition of the jams enriched with the fibers in different levels based on current legislation, in the diet of the rats, for 30 days, did not affect significantly (p = 0.05) parameters such as daily mean consumption (DMC) and daily weight gain (DWG), fecal weight, mineral absorption, glycemic responses and glycemic index of the diets and histological parameters. Moisture and ether extract contents of the stool, however, were positively affect by these ingredients. These parameters were significantly higher (p < 0.05) in groups treated with FOS and polydextrose.

Originality/value
The sugar-free Brazilian mixed fruit jam besides to increase availability and add value to exotic Brazilian fruits could be an alimentary source of interest. However, more specific studies, aimed at questioning and confirming the optimal doses of prebiotics to normal and dysglycemic individuals and with longer duration, are needed.
Hypocalcaemia and its contributing factors among first trimester pregnant women in an urban area in Malaysia
Authors: Yeop Noor Sharifatul Hana , Md Isa Zaleha , Shamsuddin Khadijah , Lin Khor Geok , Abdullah Mahdy Zaleha , Hassan Haslinda , Ghazi Hasanain 
Published: January 2018

Purpose
The aim of this study is to determine the prevalence of hypocalcaemia among first-trimester pregnant women and its contributing factors.

Design/methodology/approach
A cross-sectional study was carried out among first-trimester pregnant women who were recruited during their first antenatal visit. A total of 396 respondents of age 18-40 years completed the self-administered questionnaire (socio-demographic, socio-economic, obstetric information), validated semi-quantitative food frequency questionnaire for calcium (FFQ-calcium), anthropometric measurements (weight and height) and blood test for serum calcium during their first trimester.

Findings
The prevalence of hypocalcaemia based on serum calcium level of less than 2.11 mmol/L was 26.0 per cent (n = 103). The median serum calcium level was 2.2 mmol/L (IQR, 25th and 75th percentile – 2.1 and 2.3, respectively). Milk intake of less than two glasses per day during pregnancy showed a twofold increase in developing hypocalcaemia (OR, 2.231; 95 per cent CI, 1.399, 3.588). Other than that, underweight (aOR, 2.038; 95 per cent SK, 1.088, 3.820) and obese before pregnancy (aOR, 1.954; 95 per cent SK, 1.007, 3.790) are also predictors of hypocalcaemia.

Originality/value
The prevalence of hypocalcaemia among first-trimester pregnant women in this study was 26.0 per cent. Intake of two or more glasses of milk per day can help prevent hypocalcaemia at this stage of pregnancy.
Genetic variation in the TAS2R38 bitter taste receptor and overweight among adults in Southwest Finland
Authors: Hoppu Ulla , Lagström Hanna , Sandell Mari 
Published: January 2018

Purpose
Polymorphisms in taste receptor genes may be associated with taste sensitivity and possibly with food consumption and body weight. Previous studies relating bitter taste sensitivity to body mass index (BMI) had inconsistent findings. This paper aims to investigate the weight and body composition indicators among the TAS2R38 bitter taste receptor genotype groups.

Design/methodology/approach
Adults participating in the STEPS study (steps to the healthy development and well-being of children) cohort in Southwest Finland have been investigated. DNA has been extracted from buccal cell samples, and alleles of the gene TAS2R38 have been determined. Measurements at the follow-up visit include weight and height to calculate BMI, waist circumference (WC) and body composition with bioimpedance (women n = 757, men n = 714).

Findings
The mean BMI was 25.3 (SD 5.4) kg/m2 among women and 26.7 (SD 3.9) kg/m2 among men. BMI, WC and body fat percentage did not differ significantly between the TAS2R38 genotype groups in either gender. The proportion of subjects classified as overweight (BMI ≥ 25) did not vary significantly between the genotype groups.

Originality/value
The TAS2R38 genotype is not associated with being overweight in this cohort. Determinants of body weight are complex, and the role of other taste genotypes and phenotypes should be investigated in the future.
Application of DSM in process management of a PE commercial real estate development project
Authors: Ma Guofeng , Zhu Tiancheng 
Published: January 2018

Purpose
After the drawbacks in the process management of China PE commercial real estate development project are analyzed, it is necessary to introduce a more integrated and advanced tool to solve them. The paper aims to discuss this issue.

Design/methodology/approach
A standard process model was proposed first. Based on the model, a coupled activity dependency model was also built by structural tool design structure matrix (DSM), the detailed matrix involving 119 activities and 322 information dependencies. Next, two large processes coupled blocks were generated by the sequencing algorithm and tearing algorithm. Then, the general simulation framework with rework probability and rework effect was introduced to do empirical research for one of the activities blocks due to the merit of solving rework of DSM.

Findings
These results showed that key activities were rearranged, that information interactive scope for them was optimized and that collaborative organization interface was built. And the expected duration after simulation was 131 days at 90 percent percentile, providing the objective basis of process arrangement to some extent and decreasing the risk of prospective yields during fund period.

Originality/value
This paper is a qualitative and quantitative practical research for the process management of PE commercial real estate development projects in China based on a real project which has begun construction in 2014.
Is there such a thing as school quality culture?
Authors: Markowitsch Jörg 
Published: January 2018

PurposeThe purpose of this paper is to clarify the concept of “school quality management culture” in relation to the general notion of “school organizational culture” and to review empirical studies that scrutinised the relation between organisational culture and quality management practices in education and business.Design/methodology/approachThe paper builds on an extensive literature review that was conducted as part of a project, which intends to develop an instrument to diagnose schools’ quality management culture in initial vocational education.FindingsThe paper demonstrates that school quality (management) culture exists and differs from school (organisational) culture. A pluralist view of culture and a differentiation perspective are more appropriate to explain the complex relationship between culture and quality practices than unified or integrated approaches. However, they also pose a challenge to empirical studies because they call for longitudinal and multi-method research designs.Research limitations/implicationsThe reciprocal relation between quality practices and school culture asks for a longitudinal and comparative research design. The findings also suggest using multi-perspective and multi-method approaches, and recommend cooperation between different but comparable fields such as education, health or social work.Practical implicationsThis paper offers a literature base and a theoretical model to improve existing data collection tools to support quality management in vocational and other educational institutions.Originality/valueApart from the ideological question on whether “culture” is something an organisation is or an organisation has, the paper examines the question as to whether more “quality”-conducive cultures can be discerned from less conducive ones in schools. Furthermore, it deliberates on whether an organisation’s quality management culture is part of, or different from, an organisation’s overall culture and presents models to guide empirical analyses.