bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving speech intelligibility in noise and spatial perception: the critical role of hearing aid microphone position
Authors: Kara Eyyup , Özal Nurşah , Deniz Burcu , Çögen Talha , Deniz Rışvan , Aydın Kübra , Caba Cenk , Yılmaz Begüm Bahar 
Published: October 2024

IntroductionHearing aid (HA) manufacturers have introduced behind-the-ear (BTE) models where the microphone is positioned in the ear canal, which could impact auditory performance by distorting the pinna’s acoustic cues. This study aimed to compare two different BTE HAs with varying microphone positions: the receiver in the ear (RITE) and the transducer in the ear (TIE).MethodsThe study involved 10 participants who had never used HAs before. They used both RITE and TIE HAs bilaterally for 3 weeks. Auditory performance was assessed through free field hearing assessments (hearing thresholds, speech recognition threshold, and speech discrimination score), the Turkish Matrix Sentence Test (TURMatrix), a sound localization test, and the Satisfaction with Amplification in Daily Living (SADL) questionnaire.ResultsThere was no significant difference between TIE and RITE in the free field hearing assessments. However, TIE outperformed RITE in non-adaptive TURMatrix scores in quiet, adaptive TURMatrix scores in noise, and sound localization accuracy at various angles. SADL sub-scores (Positive Effect, Service and Cost, and Personal Image) and overall satisfaction scores were significantly better for TIE.DiscussionThe microphone position in HAs can influence auditory performance. This study demonstrated that TIE provided better speech intelligibility, localization accuracy, and user satisfaction compared to RITE.
Comprehensive liquid biopsy analysis for monitoring NSCLC patients under second-line osimertinib treatment
Authors: Ntzifa Aliki , Marras Theodoros , Kallergi Galatea , Kotsakis Athanasios , Georgoulias Vasilis , Lianidou Evi 
Published: October 2024

BackgroundThe heterogeneous and complex genetic landscape of NSCLC impacts the clinical outcomes of patients who will eventually develop resistance to osimertinib. Liquid biopsy (LB) analysis as a minimally invasive approach is a key step to efficiently identify resistance mechanisms and adjust to proper subsequent treatments. Materials and methodsIn the present study, we combined plasma-cfDNA and CTC analysis from 30 NSCLC patients in samples collected before treatment and at the progression of disease (PD). We detected molecular alterations at the DNA mutation (EGFR, PIK3CA, KRAS G12C, BRAF V600E), DNA methylation (RASSF1A, BRMS1, FOXA1, SLFN1, SHISA3, RARβ,, WIF-1, RASSF10 and APC), gene expression (CK-19, CK-18, CK-8, AXL, TWIST-1, PD-L1, PIM-1, Vimentin, ALDH-1, and B2M) and chromosomal level (HER2 and MET amplification) as possible resistance mechanisms and druggable targets. We also studied the expression of PD-L1 in single CTCs using immunofluorescence.ResultsIn some cases, T790M resistance EGFR mutation was detected at baseline in CTCs but not in the corresponding plasma cfDNA. PIK3CA mutations were detected only in plasma-cfDNA but not in corresponding CTCs. KRAS G12C and BRAF V600E mutations were not detected in the samples analyzed. MET amplification was detected in the CTCs of two patients before treatment whereas HER2 amplification was detected in the CTCs of three patients at baseline and in one patient at PD. DNA methylation analysis revealed low concordance between CTCs and cfDNA, indicating the complementary information obtained through parallel LB analysis. Results from gene expression analysis indicated high rates of vimentin-positive CTCs detected at all time points during osimertinib. Moreover, there was an increased number of NSCLC patients at PD harboring CTCs positive in PD-L1. AXL and PIM-1 expression detected in CTCs during treatment suggesting new possible therapeutic strategies. DiscussionOur results reveal that comprehensive liquid biopsy analysis can efficiently represent the heterogeneous molecular landscape and provide prominent information on subsequent treatments for NSCLC patients at PD since druggable molecular alterations were detected in CTCs.
Serum extracellular vesicles 3’tRF-ThrCGTand 3’tRF-mtlleGAT combined with tumor markers can serve as minimally invasive diagnostic predictors for colorectal cancer
Authors: Peng Jiefei , Bu Fan , Duan Lei , Song Anna , Wang Guojun , Zhang Zhijun 
Published: October 2024

BackgroundColorectal cancer (CRC) is a leading cause of morbidity and mortality, and timely diagnosis and intervention are crucial for cancer patients. Transfer RNA-derived fragments (tRFs) play a noncoding regulatory role in organisms. Serum EV(extracellular vesicles), as an integral mediator of intercellular transmission of genetic information vesicles in Transfer RNA-derived fragment (tRF RNA), are expected to be minimally invasive diagnostic and predictive biologic factors of CRC.MethodsCollect serum samples from 205 CRC patients, and then isolate extracellular vesicles from the serum. Captured the physical morphology of EV through transmission electron microscopy. The particle size was detected by particle size assay, and protein expression on the surface of EV was verified by Western blot. Gene microarrays were screened for differentially expressed tRF-RNA. TRF RNAs were verified by qPCR for differential expression in 205 CRC patients and 201 healthy donors, assessing the CRC diagnostic efficiency by area under the curve (AUC).ResultsCompared with 201 healthy donors, CRC patients experienced significantly down-regulated serum EV 3’tRF-ThrCGT while significantly up-regulated 3’tRF-mtlleGAT. Serum EV 3’tRF-ThrCGT and 3’tRF-mtlleGAT predictive diagnostic efficiency: 0.669 and 0.656, and the combination of CEA and CA724 predictive diagnostic efficiency was 0.938.ConclusionThe study data showed that 3’tRF-ThrCGT and 3’tRF-mtlelGAT can be minimally invasive diagnostic CRC indicators. The combination of tumor markers CEA and CA724 has important diagnostic significance.
The impact of the herd health interventions in small ruminants in low input production systems in Ethiopia
Authors: Moliso Mesfin Mekonnen , Molla Wassie , Arke Asrat , Nana Tesfalem , Ayele Zewudie Firdawok , Tibebu Abebe , Haile Aynalem , Rekik Mourad , Magnusson Ulf , Wieland Barbara , Knight-Jones Theodore 
Published: October 2024

IntroductionDiseases have a negative impact on production and profitability of small ruminants. A good herd health program can decrease the number of sick animals and improve herd performance.MethodsIn a longitudinal study, small ruminant herd health interventions such as community-based strategic gastrointestinal (GI) parasite control, prevention and control of major respiratory diseases and capacity development activities were implemented. In four districts of Ethiopia, where the Community Based Breeding Program (CBBP) is implemented, morbidity and mortality data were collected from January 2018 to July 2021 in 1047 smallholder farms with the objective of evaluating the impact of herd health interventions. A total of 2,643 sick animals and 516 deaths of small ruminants were recorded during the study period. The disease cases were categorized into eight groups: gastrointestinal, neurological, reproductive, respiratory, skin, systemic, other diseases (eye disease, foot disease etc) and unknown diseases. Chi-square and proportions were used to analyze morbidity and mortality by district, agro-ecological zone and age of the animal.ResultsThe data showed that the general trend in the occurrence of cases and morbidity rate were decreasing from 2018 to 2021 in intervention villages. Overall, the morbidity rate in young animals (7.36%) was highier than in adults (3.49%) and the mortality rate difference between young and adult animals was also statistically significant (p &lt; 0.001). The morbidity and mortality rates varied significantly (p &lt; 0.001) among districts and among agro-ecologies. According to the data, treating and following up of infected animals reduced the mortality rate significantly. The relative risk of death in treated animals after the case reported was 0.135. Generally, the intervention impact analysis revealed that morbidity rate was decreased in intervention years (6.31% in 2018 to 3.02% in 2021) and that herd health interventions provide an added value.ConclusionGenerally, herd health intervention had significant impact in reducing the morbidity rates in years and treatment and follow up of sick animals due to early reporting reduced mortality rate significantly. It is recommended that the herd health management should be the core activity under small ruminant production programs.
The Crystal Chemistry of Boussingaultite, (NH4)2Mg(SO4)2·6H2O, and Its Derivatives in a Wide Temperature Range
Authors: Zhitova Elena S. , Sheveleva Rezeda M. , Zolotarev Andrey A. , Shendrik Roman Yu. , Pankrushina Elizaveta A. , Turovsky Konstantin A. , Avdontceva Margarita S. , Krzhizhanovskaya Maria G. , Vlasenko Natalia S. , Zolotarev Anatoly A. , Rassomakhin Mikhail A. , Krivovichev Sergey V. 
Published: October 2024

The crystal structure, thermal behavior, and vibrational spectra of the anthropogenic analogue of boussingaultite, (NH4)2Mg(SO4)2·6H2O, and its dehydrated counterpart efremovite, (NH4)2Mg2(SO4)3, were studied in detail. The sample from the Chelyabinsk burning coal dumps has the composition of (NH4)1.92(Mg1.02Mn0.01Fe0.01)∑1.04(SO4)2·6H2O and crystallizes in the space group P21/a, with a = 9.3183(4), b = 12.6070(4), c = 6.2054(3) Å, β = 107.115(5)°, V = 696.70(5) Å3 (at 20 °C), Z = 2. The thermal evolution steps are as follows: boussingaultite (NH4)2Mg(SO4)2·6H2O (25–90 °C) → X-ray amorphous phase (100–150 °C) → efremovite (NH4)2Mg2(SO4)3 (160–340 °C) → MgSO4 Cmcm + Pbnm (340–580 °C) → MgSO4 Pbnm (580–700 °C). Thermal expansion is anisotropic, with the coefficients (×106 °C−1) α11 = 52(2), α22 = 68(2), α33 = –89(3), and αv = 31(3) at T = –123 °C; and α11 = 53(2), α22 = 67(2), α33 = 15(1), and αv = 136(3) at T = 60 °C. The maximal thermal expansion is along the b-axis and is due to straightening of corrugated pseudolayers (within the ab plane) of Mg(H2O)6 octahedra and SO4 tetrahedra with NH4 groups in the interlayer space. Vibrational spectroscopy outlines the general trend of dehydration and deammonization as the difference in the temperature intervals of these transformation steps allows separation of O–H and N–H vibrations in the process of dehydration by infrared and Raman spectroscopy. The intermediate partially dehydrated modification of boussingaultite was detected by in situ Raman spectroscopy at 110 °C that may correspond to ammonium leonite.
Characteristics of inflammatory disease structure in the maxillofacial region among children of different age groups in Krasnodar Krai
Authors: Ponomarenko T. A. , Mitropanova M. N. , Antoniadis S. S. , Lyubomirskaya E. O. , Olenskaya A. V. , Frolkina E. N. 
Published: October 2024

Relevance. Acute purulent-inflammatory diseases of the maxillofacial region (APID-MFR) are the leading cause of pediatric referrals to the maxillofacial surgery department. The prevalence of APID-MFR requiring hospitalization among children in Krasnodar and Krasnodar Krai averaged 42.9% from 2017 to 2021.Objective. To investigate the nature and structure of odontogenic and non-odontogenic inflammatory processes in patients treated at the maxillofacial surgery department of the State Healthcare Institution "Children’s Regional Clinical Hospital" (CRCH), Krasnodar.Materials and methods. Medical records of patients with inflammatory diseases of the maxillofacial region, treated in the maxillofacial surgery department at CRCH, Krasnodar, from 2017 to 2021, were analyzed. The study focused on examining the structure and characteristics of the pathology in patients receiving inpatient care.Results. The most common pathology identified in children was periostitis (30.9%), which significantly differed (p = 0.007) from the second most prevalent condition, exacerbation of chronic periodontitis (26.1%). The third place was shared by lymphadenitis (13.6%) and inflammatory skin and subcutaneous tissue diseases, including boils and carbuncles (13.5%), both of which significantly differed from the top two conditions (p < 0.001) but not from each other (p > 0.05). In fourth, fifth, and sixth places were other inflammatory skin and subcutaneous tissue diseases: abscess (10.1%), phlegmon (4.8%), and adenophlegmon (1.0%), which also significantly differed from one another.Conclusion. The high prevalence of odontogenic APID-MFR in children highlights the insufficient prevention of caries-related complications and emphasizes the need for enhanced pediatric dental care. Early diagnosis and prevention of APID-MFR complications are crucial to improving outcomes in affected children.
Afectación auditiva en personal expuesto a ruido industrial en una empresa manufacturera
Authors: Alcivar Tejena Genesis Monserrate 
Published: October 2024

La exposición diaria a ruido industrial en el lugar de trabajo puede ocasionar como resultado afectaciones auditivas en diversos niveles, el objetivo de esta investigación es identificar la incidencia de la afectación auditiva en el personal expuesto al ruido industrial en una empresa manufacturera, para ello se realizó un estudio de cohorte retrospectivo de carácter observacional en el que se analizaron los resultados de las audiometrías, porcentaje de pérdida auditiva (cd 513) y antigüedad laboral de 138 trabajadores expuesto a ruido industrial en el año 2021, los resultados demuestran predominio en las características demográficas; género masculino con 91.3%, grupo etario de 40 a 50 años y una exposición laboral a ruido industrial del 72.5% con más de 9 años en el puesto, un pequeño porcentaje (2.9%) de los trabajadores presentaron una afectación auditiva leve de ingreso, mientras que en las audiometrías actuales un 11.6% de los trabajadores presentaron una afectación auditiva leve, 1.4% una afectación auditiva moderada y el 0.7% una afectación auditiva avanzada según la clasificación de klockhoff modificado. Se concluye que hay una correlación entre la exposición laboral a ruido industrial y afectación auditiva; a mayor tiempo de exposición mayor afectación siendo esta afectación mínima en la población estudiada.
Uso de plataformas virtuales por profesionales de enfermería para educar al paciente oncológico
Authors: Lermo Sandoval Jenny Ivonne , Calixto Cruz Erika Patricia 
Published: October 2024

La educación es una actividad trascendente para lograr promover el cuidado del paciente oncológico, es así que el uso de las plataformas virtuales se han convertido en herramientas que favorecen la conectividad, mantienen la posibilidad del contacto continuo con el paciente para dar soporte necesario y promover su autocuidado; además de reducir los costos y tiempo. Este estudio tiene como objetivo, analizar el desarrollo de las evidencias científicas sobre educación de enfermería a través de plataformas virtuales a los pacientes oncológicos. La metodología fue una revisión integrativa, utilizando 6 bases de datos: PudMed, Alicia, SciELO, Embase, DOAJ y Google Académico. Se incluyó artículos en inglés y español de los últimos 7 años. Los resultados encontraron 22 artículos sobre recursos digitales, siendo medios que proporcionan información y educación; por lo que la enfermera debe aplicar estrategias pedagógicas para asumir el autocuidado en los pacientes oncológicos. Es importante resaltar que la educación debe estar de acuerdo al tipo de paciente tanto en la virtualidad y en la presencialidad. Se concluye que los enfermeros pueden incluir en las actividades cotidianas las prácticas educativas, utilizando los recursos digitales para sostener el autocuidado del paciente oncológico, favoreciendo su bienestar y calidad de vida.
Fundamental Parameters of a Binary System Consisting of a Red Dwarf and a Compact Star
Authors: Ding Xu , Ji KaiFan , Song ZhiMing , Liu NianPing , Xiong JianPing , Cheng Qiyuan , Wang ChuanJun , Wang JinLiang , Wang DeQing , He ShouSheng 
Published: October 2024

Abstract
TIC 157365951 has been classified as a δ Scuti type by the International Variable Star Index. Through the spectra from Large Sky Area Multi-Object Fiber Spectroscopic Telescope and its light curve, we further discovered that it is a binary system. This binary system comprises a red-dwarf star and a compact star. Through the spectral energy distribution fitting, we determined the mass of the red dwarf star as M
1 = 0.31 ± 0.01M
⊙ and its radius as R
1 = 0.414 ± 0.004R
⊙. By fitting the double-peaked Hα emission, we derived the mass ratio of q = 1.76 ± 0.04, indicating a compact star mass of M
2 = 0.54 ± 0.01M
⊙. Using Phoebe to model the light curve and radial velocity curve for the detached binary system, we obtained a red dwarf star mass of M
1 = 0.29 ± 0.02M
⊙, a radius of R
1 = 0.39 ± 0.04R
⊙, and a Roche–lobe filling factor of f = 0.995 ± 0.129, which is close to the f = 1 expected for a semidetached system. The Phoebe model gives a compact star mass M
2 = 0.53 ± 0.05M
⊙. Constraining the system to be semidetached gives M
1 = 0.34 ± 0.02M
⊙, R
1 = 0.41 ± 0.01R
⊙, and M
2 = 0.62 ± 0.03M
⊙. The consistency of the models is encouraging. The value of the Roche–lobe filling factor suggests that there might be ongoing mass transfer. The compact star mass is as massive as a typical white dwarf.
The Peculiar Disk Evolution of 4U 1630-472 Observed by Insight-HXMT During its 2022 and 2023 Outbursts
Authors: Peng Jing-Qiang , Zhang Shu , Shui Qing-Cang , Chen Yu-Peng , Zhang Shuang-Nan , Kong Ling-Da , Santangelo A. , Yu Zhuo-Li , Ji Long , Wang Peng-Ju , Chang Zhi , Li Jian , Li Zhao-sheng 
Published: October 2024

Abstract
We study the spectral properties of the black hole X-ray transient binary 4U 1630–472 during its 2022 and 2023 outbursts with Insight-HXMT observations. We find that the outbursts are in peculiar soft states. The effect of the hardening factor on the disk temperature is taken into account by the kerrbb model, and the flux and temperature of the disk are found to follow

F
∝

T

eff

3.92
±
0.13

and

F
∝

T

eff

4.91
±
1.00

for the two outbursts, respectively. The flux–temperature relation is roughly consistent with a standard disk. By fitting with a p-free model, the p-value, the exponent of the radial dependence of the disk temperature, is found to have an anticorrelation with disk temperature. Combining a joint diagnostic analysis with a diagram of the relation between the nonthermal fraction and luminosity, we find a possible scenario that the disk evolves from 2022 to 2023 toward a slim one with a decreasing radiation efficiency, where such an evolution may depend on the fraction of the nonthermal emission in the high soft state.
Numerical Experiment on the Influence of Granulation-induced Waves on Solar Chromosphere Heating and Plasma Outflows in a Magnetic Arcade
Authors: Kumar M. , Murawski K. , Kuźma B. , Kilpua E. K. J. , Poedts S. , Erdélyi R. 
Published: October 2024

Abstract
This paper offers a fresh perspective on solar chromosphere heating and plasma outflows, focusing on the contribution of waves generated by solar granulation. Utilizing a 2.5D numerical experiment for the partially ionized lower solar atmosphere, we investigate the dissipation of these waves and their impact on plasma outflows and chromospheric heating via ion-neutral collisions. Employing the JOint ANalytical and Numerical Approach code, we adopt two-fluid model equations, examining partially ionized hydrogen plasma dynamics, including protons+electrons and neutrals, treated as two separate fluids that are coupled through ion-neutral collisions. Our investigation focuses on a quiet solar chromosphere region characterized by gravitational stratification and magnetic confinement by an initially set single magnetic arcade. The primary source of the waves is the solar convection beneath the photosphere. Our results demonstrate that ion-neutral collisions result in the dissipation of such waves, releasing thermal energy that heats the chromosphere plasma. Notably, this is accompanied by upward-directed plasma flows. Finally, we conclude that wave dissipation due to ion-neutral collisions in the two-fluid plasma model induces chromosphere heating and plasma outflows.
Tidal Spin-up of Subdwarf B Stars
Authors: Ma 马 Linhao 林昊 , Fuller Jim 
Published: October 2024

Abstract
Hot subdwarf B (sdB) stars are stripped helium-burning stars that are often found in close binaries, where they experience strong tidal interactions. The dissipation of tidally excited gravity waves alters their rotational evolution throughout the sdB lifetime. While many sdB binaries have well-measured rotational and orbital frequencies, there have been few theoretical efforts to accurately calculate the tidal torque produced by gravity waves. In this work, we directly calculate the tidal excitation of internal gravity waves in realistic sdB stellar models and integrate the coupled spin–orbit evolution of sdB binaries. We find that for canonical sdB (M
sdB = 0.47 M
⊙) binaries, the transitional orbital period below which they could reach tidal synchronization in the sdB lifetime is ∼0.2 day, with weak dependence on the companion masses. For low-mass sdBs (M
sdB = 0.37 M
⊙) formed from more massive progenitor stars, the transitional orbital period becomes ∼0.15 day. These values are very similar to the tidal synchronization boundary (∼0.2 day) evident from observations. We discuss the dependence of tidal torques on stellar radii, and we make predictions for the rapidly rotating white dwarfs formed from synchronized sdB binaries.
Des « atlas » aux « archives » du monde. À propos des Archives de la parole (1911‑1924) et des Archives de la planète (1912‑1931)
Authors: Castro Teresa 
Published: October 2024

Autour de 1900, au moment où plusieurs collections d’images photographiques et cinématographiques commencent à prendre forme, les termes « atlas » et « archives » se croisent sans cesse, attestant une interaction conceptuelle entre deux formes distinctes de mise en ordre des connaissances. En s’appuyant sur deux études de cas – les Archives de la parole (1911-1924) et les Archives de la planète (1912-1931) –, l’auteure défend l’hypothèse que l’imposition progressive du paradigme de l’archive aux collections réunissant images photographiques, images animées et enregistrements sonores est à la fois liée à la consolidation d’un régime d’historicité particulier – appuyé sur un sentiment partagé d’une accélération du présent et sur la croyance typiquement moderne dans le progrès – et au développement de nouvelles techniques d’enregistrement et de reproduction mécanisée – le phonographe, la photographie, le film.
Temporalités cachées dans Campo urbano, Côme, 1969
Authors: Golan Romy 
Published: October 2024

Dans la journée du 21 septembre 1969, quarante artistes investirent la ville de Côme avec une série d’interventions annoncées par une distribution de tracts. Campo urbano. Interventi estetici nella dimensione collettiva urbana fut coordonnée par l’historien Luciano Caramel, le photographe Ugo Mulas et Bruno Munari. Alors que d’autres interventions artistiques des années 1960 utilisèrent l’imprimé comme outil de documentation de la performance, le livre des photographies de Campo urbano est unique. Suivant les indications de Munari, les images furent imprimées à fond perdu, faisant alterner planches contact, vues d’en haut et clichés panoramiques. Un effet dynamique était créé en retournant les images, et Munari, afin de simuler une action d’effacement, avait pris le parti de virer dans un bleu céruléen les négatifs noir et blanc de Mulas. Rien ne pouvait être plus présentiste que ce livre et, pourtant, l’auteure nous montre que Munari a voulu déclencher une série d’associations visuelles avec des périodes plus anciennes de l’art italien et avec des épisodes fugaces d’une histoire encore non écrite de la participation.