bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination
Authors: Chen Bo-Ruei , Pham Thu , Reynolds Lance D. , Dang Nghi , Zhang Yanfeng , Manalang Kimberly , Matos-Rodrigues Gabriel , Neidigk Jason Romero , Nussenzweig Andre , Tyler Jessica K. , Sleckman Barry P. 
Published: September 2024

AbstractNon-homologous end joining (NHEJ) is required for repairing DNA double strand breaks (DSBs) generated by the RAG endonuclease during lymphocyte antigen receptor gene assembly by V(D)J recombination. The Ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) kinases regulate functionally redundant pathways required for NHEJ. Here we report that loss of the senataxin helicase leads to a significant defect in RAG DSB repair upon inactivation of DNA-PKcs. The NHEJ function of senataxin is redundant with the RECQL5 helicase and the HLTF translocase and is epistatic with ATM. Co-inactivation of ATM, RECQL5 and HLTF results in an NHEJ defect similar to that from the combined deficiency of DNA-PKcs and senataxin or losing senataxin, RECQL5 and HLTF. These data suggest that ATM and DNA-PKcs regulate the functions of senataxin and RECQL5/HLTF, respectively to provide redundant support for NHEJ.
FerroEnrich: An Interactive web tool for computing Ferroptosis index and gene enrichment
Authors: Tirumalasetty Munichandra Babu , Choubey Mayank , Wahiduzzaman Md , Barua Rashu , Mohiuddin Mohammad Sarif , Miao Qing Robert 
Published: September 2024

AbstractFerroptosis is an iron-dependent form of controlled cell death and is characterized by the formation of lipid peroxides. Understanding gene expressions associated with ferroptosis is critical for determining its function in illnesses and potential therapeutic approaches. Despite its significance, no computational model is currently available to accurately quantify the ferroptosis incident. FerroEnrich is a sophisticated web-based tool built using R Shiny application to enumerate the occurrence of ferroptosis based on the relevant gene expressions. This tool available athttps://ferroenrich.shinyapps.io/ferroenrich/processes the input gene expression file to identify genes that are resistant or prone to ferroptosis, calculates ferroptosis index value with dynamic colored heatmap and gene network plot. This manuscript describes the design, operation and usability of FerroEnrich, including examples and a discussion of its potential impact on ferroptosis research. FerroEnrich is a vital tool for researchers, allowing them to explore and analyze complicated gene expression data related to ferroptosis.
Societal bonds in virtual spaces: exploring the sense of community in online student communities at Anadolu University’s Open Education System
Authors: Uçar Merve , Güler Emel , Koçdar Serpil 
Published: September 2024

PurposeThis study aims to investigate the levels of the sense of community among students enrolled in online student communities at Anadolu University Open Education System (OES), as well as their motivations for joining these communities and their expectations.Design/methodology/approachAn explanatory sequential design incorporating mixed research methods was employed as the research framework for this study. Quantitative data were collected from 1,065 students enrolled in online student communities during the 2021–2022 academic year, while qualitative data were obtained from 14 students after the survey using an extreme case sampling method. The quantitative data were analyzed using descriptive statistics, independent samples t-tests, one-way analysis of variance tests, correlation analysis and regression analysis. The qualitative data were analyzed using content analysis.FindingsThe study results indicate that students enrolled in online student communities generally have higher levels of a sense of community. These levels did not significantly differ based on gender, employment status, entry type to the university, program studied or membership status in more than one community. However, significant differences were observed in terms of age, time spent in communities and meeting attendance. Additionally, students' perceptions of social presence had a significant effect on their sense of community.Originality/valueThis study is the first to investigate the sense of community in online student communities at Anadolu University's OES.
From physical degradation condition ratings of building elements to lost value ratio bands
Authors: Wickramasinghe Vajira , Dias Priyan , Robert Dilan , Setunge Sujeeva 
Published: September 2024

PurposeDefining degradation in terms of physical deficiency-based condition descriptors, combined with Markov chain modelling, has been shown to provide improved predictions of degradation. However, unless these physical conditions are converted to lost value ratios (LVRs), maintenance managers would not be able to grasp the cost implications of degradation. Hence the purpose of this research is to convert the predicted deficiency-based condition ratings to lost value ratio bands.Design/methodology/approachRectification costs were found using a Building Schedule of Rates to arrive at LVRs for each of the physical degradation conditions for the 12 building elements studied (ranging from concrete elements through finishes and ceilings to doors and windows). These LVRs were allocated into five bands with LVR interval limits of 0.00, 0.10, 0.25, 0.50, 0.75 and 1.00, with the five intervening ranges corresponding to LVR Bands A to E. These computations were compared with those arrived at independently by industry professionals.FindingsElements such as doors, widows and ceilings reached the maximum LVR Band E at the worst physical Condition 5 defined. However, Condition 5 for other elements only corresponded to LVR Bands A to D. Some 83% of the LVR bands assigned to the physical conditions were in agreement with those arrived at by the professionals, or differed by only one band.Originality/valueThe conversion of deficiency-based conditions to LVR bands yielded a completely new maintenance-oriented perspective on degradation. The banding was done using a novel ranking and clustering process that identified regions of high variation in LVRs as thresholds of the bands.
Leveraging technological readiness and knowledge sources for green innovation: a resource orchestration perspective
Authors: Khayyam Muhammad , Yushi Jiang , Liu Qiqi , Idrees Hisham , Qin Shengze , Nurlegul Alinur 
Published: September 2024

PurposeThis study delves into the intricate dynamics between technological readiness, knowledge sources and their collective impact on firms' ability to achieve ambidextrous green innovation (GI). It specifically aims to dissect the moderating influence of resource orchestration capability (ROC) in this nexus, proposing a nuanced exploration into how technological preparedness and the strategic utilisation of both internal and external knowledge sources can significantly steer firms towards successful exploitative and exploratory GI endeavours.Design/methodology/approachThe study draws upon resource orchestration theory, integrating a cross-sectional approach that incorporates primary data from Pakistani manufacturing firms. The data consisting of 452 responses was analysed employing Partial Least Squares Structural Equation Modelling (PLS-SEM).FindingsThe research verifies that technological readiness has a substantial influence on exploitative and exploratory GI. Moreover, it reveals that both internal and external knowledge resources mediate the link between technological readiness and ambidextrous GI. Notably, while ROC enhances the favourable impact of external knowledge resources on both types of GI, it does not significantly moderate the effect of internal knowledge sources.Practical implicationsManagers must prioritize enhancing technological preparedness and strategically coordinating knowledge resources to drive both exploitative and exploratory environmentally friendly innovation. Investments in technology and collaborations with external partners, guided by strong resource management capabilities, are crucial for achieving sustainable innovation.Originality/valueThis research contributes to ambidextrous GI literature by examining the roles of technological readiness, mediated by internal and external knowledge sources and moderated by ROC. It offers detailed insights into the mechanisms that promote sustainable innovation, enriching the current understanding of the subject.
Internet of things platforms adoption in agriculture: comparative theoretical models
Authors: Zamil Ahmad M.A. , Javed Hafiz Muhammad Usama , Ali Saqib 
Published: September 2024

PurposeThe purpose of this study is to determine the farmers’ behavioural intention (BI) to adopt Internet of things platforms (IoT-P) in the agriculture context by comparing two well-known theories: the united theory of acceptance and use of technology (UTAUT), and the decomposed theory of planned behaviour (DTPB) with the integration of innovation resistance theory (IRT).Design/methodology/approachPurposive sampling was used to get responses from 267 potential farmers to examine their IoT-P adoption intention in Pakistan. The PLS-SEM, PLS model evaluation criterion and PLS model selection criterion were considered to determine the significance of path co-efficient, explanatory power, predictive power and more parsimonious model.FindingsThe findings demonstrate that DTPB is the best model with the extension of functional barriers (FBs) and psychological barriers (PBs). It has more predictive relevance and explanatory power. The results show that farmers’ attitude (ATT), based on the evaluation of three attributes (i.e. perceived usefulness (PU), perceived ease of use (PEOU) and compatibility (COMP)), is the strong predictor of farmers’ BI to adopt IoT-P. In addition, self-efficacy (SEF) and facilitating conditions (FC) peer influence (PI) and superiors’ influence (SPI) are required for adoption of IoT-P devices. Finally, FB and PB significantly and negatively influence the farmers’ BI to adopt IoT-P.Originality/valueThis research is the first to consider the two technology adoption models with the integration of IRT for explaining farmers’ BI in the context of agriculture.
The impact of Sharia compliance on attracting investments: empirical evidence from GCC
Authors: Tawfik Omar Ikbal , Elmaasrawy Hamada Elsaid , Hussainey Khaled 
Published: September 2024

Purpose
This study aims to demonstrate the impact of Sharia-compliance (SC) on attracting various types of investment, including foreign, family, institutional, royal, government and large individual investments.

Design/methodology/approach
The sample comprises 168 nonfinancial companies listed in the financial markets of the Gulf Cooperation Council (GCC) countries from 2009 to 2019, totaling 1,848 observations. The researchers used the ordinary least squares panel data method, with additional tests conducted using the two-stage least squares method.

Findings
The results indicate a negative relationship between SC and both foreign and institutional investments. Conversely, there is a positive relationship between SC and both family investment and large individual investor investment. Furthermore, the study found no significant relationship between SC and both government and royal investments (RIs).

Practical implications
The study enhances understanding of the role of Sharia-compliant companies in attracting investment. For managers of such companies, there is a need to make their firms more appealing to diverse investor types. Current and potential investors in Sharia-compliant companies should be aware of the investor nature controlling these companies. This study is beneficial for policymakers and regulators to assess the impact of Islamic Sharia-imposed restrictions on financial decision-making in companies. Policymakers should develop and monitor indicators of companies’ adherence to SC law in the six GCC countries and should also issue rules to enhance Sharia-compliant companies’ commitment to governance and transparency.

Originality/value
To the best of the authors’ knowledge, this study is the first of its kind to address the impact of SC on attracting different investment types. It includes six distinct investment types, notably RI, a significant variable in GCC countries’ business environment due to the considerable wealth and influence of royal family members.
Sustainability reporting in public–private hybrid organisations: a structured literature review
Authors: Ligorio Lorenzo , Caputo Fabio , Venturelli Andrea 
Published: September 2024

PurposeThe growing interest in sustainability reporting by management scholars is leading to new research fields. Among the different actors involved in non-financial disclosures, recent research is paying attention to public–private hybrid organisations. This study explores the main focus and critique of current and past literature on public–private hybrids and sustainability reporting.Design/methodology/approachTo explore the recent field of sustainability reporting in public–private hybrids, this study adopts a structured literature review on studies collected from the scientific platforms Scopus and Web of Science.FindingsFindings revealed a young and growing field of research. Also, it emerged how more profound attention is being paid to the features and drivers of sustainability reporting in the public–private sector, along with a stimulus for further research on new reporting frameworks.Research limitations/implicationsConsidering the novelty of the research field, the collection of analysed studies was very limited. Moreover, grey literature was not incorporated into the research. In addition, only two sources of data were considered.Practical implicationsThis study includes different implications regarding sustainability reporting in public–private hybrids, emphasizing transparency, accountability and the need for further research and adoption of external assurance.Originality/valueBecause of the novelty of the research field, this is the first study to focus on literature that addresses the relationship between sustainability reporting and public–private entities. Furthermore, using a structured literature review has provided a profound view of the published literature.
Term structure of interest rate and macro economy: an empirical study on selected emerging countries sovereign bond
Authors: Ariefianto Doddy , Amanda Citra , Ananto Husodo Zaafri 
Published: September 2024

PurposeTo examine the relationship between the term structure of interest rates of sovereign bonds in emerging nations and their macroeconomic indicators, specifically emphasizing its persistence and interaction with inflation, foreign exchange and fiscal conditions.Design/methodology/approachAdopting the Mean Group Instrumental Variables (MGIV) technique, as proposed by Cui et al. (2020) and Norkute et al. (2021), this study analyzes a monthly panel dataset from nine emerging economies spanning January 2010 to October 2021, totaling 1,278 observations.FindingsThe findings reveal significant persistence in both slope and curvature, with a rising yield level linked to the term structure's flattening, while shifts in inflation and exchange rates correlate with its steepening.Originality/valueOur study is among the few which used an empirically constructed measure of the term structure of interest instead of a theoretical construct. To best our knowledge, we are the first to employ MGIV.
The use of critical reflection in one-to-one supervision in children and families social work in England: an evidence review
Authors: Leonard Kate 
Published: September 2024

Purpose
English social work policies and regulatory bodies propel critical reflection as a professional requirement and a worthwhile activity. The purpose of this paper is to report on the current international and UK evidence that informs the understanding and use of critical reflection and associated terms – reflection, reflective practice and reflective supervision – in one-to-one practitioner supervision in local authority children and families social work in England.

Design/methodology/approach
A review of the evidence was undertaken using documentary policy analysis and a scholastic literature review to examine the history and current knowledge available as of December 2022.

Findings
The historical policy and professional context of critical reflection in one-to-one supervision in England is discussed. The current evidence review identified three themes – the role of critical reflection in models of supervision, the influences of national, organisational and professional cultures and the supervisor practitioner relationship. The nuanced nature of the presence of critical reflection in supervision and a lack of clarity when theorising and describing critical reflection has implications for policy, supervisory practice and research design.

Originality/value
Critical reflection in one-to-one social work supervision is under researched. This review draws on the evidence from international research and local policy to offer an understanding of the complexity of theorising, practicing and researching critical reflection in one-to-one supervision in local authority children and families social work in England.
Impact of nations’ green behavior on green growth by considering the moderating role of environmental policy stringency
Authors: Awan Amara , Hussain Kashif , Zafar Mahwish , Butt Maryam Javed , Yaghmour Samer 
Published: September 2024

PurposeProtecting the planet from unprecedented environmental crises in the presence of economic expansion has become a critical global concern. Hence, the current study aims to analyze the impact of nations’ green behaviors that they adopt to protect the planet while promoting economic expansion. Additionally, the study explores the moderating role of ES in the nexus of GI and green growth.Design/methodology/approachData were collected over a period of 1990–2019. Analysis was conducted by employing panel data analysis techniques and various robustness tests, including multicollinearity, serial correlation and spatial correlation, for a sample of 33 nations by categorizing in Organization for Economic Co-operation and Development (OECD) and Brazil, Russia, India, China, and South Africa (BRICS) economies as well as in the pre- and post-financial crisis period.FindingsAnalysis of the composite sample reveals a significant positive impact of green investments and green innovations on green growth. Further analysis reveals a significant moderating role of environmental policy stringency in OECD economies, especially in the pre-financial crisis period. The interaction slope shows that the contribution of green innovations to green growth is positive at high and medium levels of ES. However, in the case of BRICS economies, this moderating role is insignificant.Practical implicationsStudy findings signify the importance of stakeholder environment and urge governments to prioritize funds for sectors practicing environmentally friendly behaviors to foster green growth and stresses for more effective infrastructure of policy implementation, monitoring and evaluation.Originality/valueThe relationship of green investments, innovations and green growth has been established largely in existing literature; however, there is a dearth of studies to analyze the moderating role of ES. Hence the current study investigates this moderating role in the nexus of nations’ green behavior and green growth in different stakeholder environments and contexts.
Study on axial and bending stiffness characteristics of reinforced S-shaped bellows
Authors: Yuan Zhe , Huo Shihui 
Published: September 2024

PurposeReinforced S-shape bellows are novel metal bellows with high pressure resistance. Displacement compensation ability is a key index in the design of metal bellows. Axial-tension-compression deformation and bending deformation are two typical displacement compensation forms. Thus, analysis of axial and bending stiffness is important in structure design.Design/methodology/approachIn this study, theory analytics of axial tension and compression stiffness of reinforced S-shaped bellows structure is derived, and the load-displacement relationship during axial deformation is obtained by correcting the geometric parameters of waveform during axial tension and compression deformations. On the basis of them, the relationships of bending stiffness with axial tensile and compression stiffness under the action of bending loading are constructed, and thus, the theory analytics of bending stiffness is realized for S-shaped bellows.FindingsThis theory analytics is verified by comparing the results of theory analytics with those of numerical simulation for a few typical examples. An investigation on the axial and bending non-linear mechanical behaviors of multi-layer-reinforced S-shaped bellows was also carried out by numerical simulation and experiment, and the experimental results verified the reliability of the analysis method.Originality/valueIt is found that non-linearity behavior occurs greatly during the first loading course of reinforced S-shaped bellows, and the structure is strain-strengthened due to plastic deformation; however, stable stiffness characteristic is exhibited during the succeeding cyclic-loading course.
The role of chief medical officers in the Italian context: managers or clinicians?
Authors: Pratici Lorenzo , Fanelli Simone , Francesconi Andrea , Zangrandi Antonello 
Published: September 2024

Purpose
Despite the advent of New Public Management theories over three decades ago, doubts persist regarding the practical implementation of these principles in the public health-care context. Challenges arise particularly from the type of system where this phenomenon is analyzed. In the Italian context, for instance, it can be arduous to define universally applicable organizational behaviors, given the interregional disparity that characterizes such a system. Furthermore, the professional identity of clinician-managers influences the perception of what “being a manager” means. This paper, thus, using the Italian context as a reference, aims to delineate what is the perception of Italian public hospitals clinician-middle-managers in terms of their responsibilities and tasks.

Design/methodology/approach
A survey-questionnaire was distributed to 6,011 Chief Medical Officers (CMOs) in Italian public hospitals, representing 100% of such role holders in the country. With a response rate of 16.7%, 1,005 responses were obtained. The questionnaire assessed CMOs' attitudes toward specific activities relevant to clinician-management, ranked from most to least important. Activities were derived from literature and categorized to discern management styles. Subgroups based on geographical location and professional orientation were also identified to isolate regional effects and professional identity influences.

Findings
Results suggested that activities associated with a collaborative approach are perceived as most important. Furthermore, it clearly emerges the difference based on professional orientation of CMOs. However, it could not be appreciated the same level of difference basing the analysis on regional disparities.

Originality/value
The interest in the role of middle management in healthcare organizations has increased over the years. Nevertheless, currently the authors believe that not many studies are focused on defining what “being a manager” means for clinician-managers themselves, rather than explaining what clinician-managers shall do.