bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing Loss in Diabetes Mellitus – Correlation with Otoacoustic Emissions
Authors: Munjal Manish , Kaur Hardeep , Puri Sanjeev , Mittal Naveen , Munjal Shubham 
Published: September 2024

Abstract

Background:
Patients with diabetes mellitus with hearing loss were analyzed for the effect of diabetes mellitus on the outer hair cells.

Materials and Methods:
Thirty patients with diabetes mellitus who visited to ENT and endocrinology outpatient clinics were analyzed for the effect of diabetes mellitus on hearing, between March 1st, 2021, and August 31st, 2022, in this prospective study.

Statistical Analysis:
On measurement of Mean and Standard Deviation- Pure tone average shows high hearing threshold in higher frequencies with increase in HbA1c levels (P = 0.001). With increase in HbA1C amplitude of recorded waves for OAE in 29 diabetics were significantly lower (P = 0.001) which attributed to disorder in the hair cells of the cochlea Categorical data were presented as percentages and Chi-square test was used to derive comparisons. For all statistical testing, P = 0.05 was considered significant. The incidence of hearing loss was analyzed from the data of otoacoustic emissions (OAE). All the clinic demographic factors were studied and correlations of hearing loss in diabetics were made to various positive risk factors.

Results:
In the present study, only 3.3% of subjects exhibited OAE. With an increase in glycosylated hemoglobin (P = 0.001), the distortion product OAE (DPOAE) amplitude decreased. Majority, i.e., 12 (41.3%) had reduced amplitude of DPOAE at 6 kHz, followed by 9 (31.2%) at 4 kHz, 5 (17.2%) at 2 kHz, and 3 (10.3%) at 8 kHz. Males predominated, i.e., 21 (72.4%) in comparison to the females 9 (27.5%).

Conclusions:
Diabetes has been associated with hearing impairment secondary to alterations in the organ of Corti and the stria vascularis. Hearing deficit is also attributed to the combined effect of hyperglycemia and oxidative stress leading to cochlear microangiopathy and auditory neuropathy. The quality of life improves in diabetics with control of the glycemic index.
Dilated cardiomyopathy subsequent to anabolic-androgenic steroid abuse
Authors: Natarajan Deepak 
Published: September 2024

Abstract
Elite athletes and males frequently use anabolic-androgenic steroids (AAS) to enhance performance and enhance physique. There have been reports of severe cardiovascular adverse effects in AAS users. This report describes the uncommon instance of a 40-year-old male without any other risk factors developing dilated cardiomyopathy, subsequent to AAS abuse for the previous 8 years. The precise mechanism by which AAS causes cardiomyopathy remains unclear. There are as yet no guidelines formulated for the treatment of AAS-induced cardiomyopathy. Anabolic androgenic-induced cardiomyopathy must be familiarized by physicians when confronted with a case of dilated cardiomyopathy.
Does Physiological Intracytoplasmic Sperm Injection Improve Outcome in Men with Abnormal Semen Parameters: A Retrospective Cohort Study
Authors: Shivhare Swati , Karunakaran Sandeep , Bose Ananda Swarup , Goel Rishu , Ananthakrishnan R. 
Published: September 2024

Background:
As the male factor in infertility is on rising trend, we need a promising tool for sperm selection to improve the embryo development.

Aim:
The present study compares the embryological and clinical parameters between physiological intracytoplasmic sperm injection (PICSI) and conventional intracytoplasmic sperm injection (ICSI) in abnormal semen parameters.

Settings and Design:
This was a retrospective cohort study.

Materials and Methods:
This study was conducted over the duration of 9 months from April to December 2023. One hundred and four patients, who matched the inclusion and exclusion criteria, were enrolled in the study. The adjusted blastulation rate was evaluated as the primary outcome, and the secondary outcomes studied were fertilisation rate, good-quality cleavage stage embryo rate, clinical pregnancy and miscarriage rate.

Statistical Analysis Used:
The outcome measures were calculated using independent Student’s t-test, and P < 0.5 was considered statistically significant.

Results:
The 104 enrolled patients were divided into two groups. In the study population (n = 51), PICSI was used for sperm selection and the controls (n = 53) used conventional ICSI. The adjusted blastulation rate was statistically significant higher in the PICSI group (43.7%) as compared to the controls (34.2%) (P = 0.022). The fertilisation and cleavage rates were not statistically different amongst the groups. The pregnancy rate (37.2% vs. 32%, P = 0.027) and miscarriage rate (5.3% vs. 11.7%, P = 0.005) were statistically better in the PICSI group.

Conclusion:
PICSI may improve treatment outcomes in couples undergoing assisted reproduction for male factor infertility. However, larger randomised controlled trials are needed for validating the current study findings.
Pharmacists’ Counseling and Benzodiazepines Dispensing for Sleep Disorders: A Simulated Patient Study in Iran
Authors: Banitaba Joshaghani Fatemeh , Sarahroodi Shadi 
Published: September 2024

ABSTRACT

Objective:
Sleep is critical for good health and quality of life, but many people struggle with sleep disorders. Pharmacists are on the front lines, helping patients manage these problems. However, there is growing concern that some pharmacists are dispensing benzodiazepines over-the-counter and failing to provide proper counseling. This study examined how pharmacists in Iran performed in these areas.

Methods:
Between January and April 2022, we conducted a cross-sectional study in three major Iranian cities, using a “simulated patient” to observe how pharmacists interacted with them. In total, 431 pharmacies participated, and we used detailed forms to record the pharmacists’ behavior. We then analyzed the data using descriptive statistics and the Chi-square tests.

Findings:
Of 549 visits, 78.5% were managed by pharmacists, whereas the remainder were managed by other pharmacy staff. 79.7% of pharmacists evaluated the patient before deciding whether or not to prescribe the medication and 58.9% provided a kind of counseling for their offered medication, but just 10.6% of pharmacies had a private counseling area. Despite regulations that require a valid prescription for benzodiazepines, 9.2% of pharmacies dispensed diazepam, and 13.2% dispensed alprazolam without requesting one, and when counseling was offered, it often lacked critical details.

Conclusion:
These findings raise serious concerns. There are deficiencies in how pharmacists and patients interact, with many pharmacists spending minimal time assessing patient needs. The high rates of benzodiazepine dispensing without valid prescriptions and inadequate counseling point to a need for stricter protocols and more training. To address these issues, health-care professionals and policymakers must collaborate to improve the quality and safety of sleep disorder treatment in community pharmacies.
Local excision of early rectal cancer: A multi-centre experience of transanal endoscopic microsurgery from the United Kingdom
Authors: Farid Ahmed , Tutton Matthew , Thambi Prem , Gill TS , Khan Jim 
Published: September 2024

BACKGROUND
Total mesorectal excision remains the gold standard for the management of rectal cancer however local excision of early rectal cancer is gaining popularity due to lower morbidity and higher acceptance by the elderly and frail patients.
AIM
To investigate the results of local excision of rectal cancer by transanal endoscopic microsurgery (TEMS) approach carried out at three large cancer centers in the United Kingdom.
METHODS
TEMS database was retrospectively reviewed to assess demographics, operative findings and post operative clinical and oncological outcomes. This is a retrospective review of the prospective databases, which included all patients operated with TEMS approach, for early rectal cancer (Node-negative T1-T2), selected T3 in unfit/frail patients.
RESULTS
Two hundred and twenty-two patients underwent TEMS surgery. This included 144 males (64.9%) and 78 females (35.1%), Median age was 71 years. The median distance of the tumours from the anal verge 4.5 cm. Median tumour size was 2.6 cm. The most frequent operative position of the patient was lithotomy (32.3%), Full-thickness rectal wall excision was done in 204 patients. Median operating time was 90 minutes. Average blood loss was minimal. There were two 90-day mortalities. Complete excision of the tumour with free microscopic margins by > 1mm were accomplished in 171 patients (76.7%). Salvage total mesorectal excision was performed in 42 patients (19.8%). Median disease-free survival was 65 months (range: 3-146 months) (82.8%), and median overall survival was 59 months (0-146 months).
CONCLUSION
TEMS provides a promising option for early rectal cancers (Large adenomas-cT1/cT2N0), and selected therapy-responding cancers. Full-thickness complete excision of the tumour is mandatory to avoid jeopardising the oncological outcomes.
Recurrence scoring system predicting early recurrence for patients with pancreatic ductal adenocarcinoma undergoing pancreatectomy and portomesenteric vein resection
Authors: He Hang , Zou Cai-Feng , Jiang Yong-Jian , Yang Feng , Di Yang , Li Ji , Jin Chen , Fu De-Liang 
Published: September 2024

BACKGROUND
Pancreatectomy with concomitant portomesenteric vein resection (PVR) enables patients with portomesenteric vein (PV) involvement to achieve radical resection of pancreatic ductal adenocarcinoma, however, early recurrence (ER) is frequently observed.
AIM
To predict ER and identify patients at high risk of ER for individualized therapy.
METHODS
Totally 238 patients undergoing pancreatectomy and PVR were retrospectively enrolled and were allocated to the training or validating cohort. Univariate Cox and LASSO regression analyses were performed to construct serum recurrence score (SRS) based on 26 serum-derived parameters. Uni- and multivariate Cox regression analyses of SRS and 18 clinicopathological variables were performed to establish a Nomogram. Receiver operating characteristic curve analysis was used to evaluate the predictive accuracy. Survival analysis was performed using Kaplan-Meier method and log-rank test.
RESULTS
Independent serum-derived recurrence-relevant factors of LASSO regression model, including postoperative carbohydrate antigen 19-9, postoperative carcinoembryonic antigen, postoperative carbohydrate antigen 125, preoperative albumin (ALB), preoperative platelet to ALB ratio, and postoperative platelets to lymphocytes ratio, were used to construct SRS [area under the curve (AUC): 0.855, 95%CI: 0.786–0.924]. Independent risk factors of recurrence, including SRS [hazard ratio (HR): 1.688, 95%CI: 1.075-2.652], pain (HR: 1.653, 95%CI: 1.052-2.598), perineural invasion (HR: 2.070, 95%CI: 0.827-5.182), and PV invasion (HR: 1.603, 95%CI: 1.063-2.417), were used to establish the recurrence nomogram (AUC: 0.869, 95%CI: 0.803-0.934). Patients with either SRS > 0.53 or recurrence nomogram score > 4.23 were considered at high risk for ER, and had poor long-term outcomes.
CONCLUSION
The recurrence scoring system unique for pancreatectomy and PVR, will help clinicians in predicting recurrence efficiently and identifying patients at high risk of ER for individualized therapy.
Penerapan Bauran Pemasaran Karkas Ayam Broiler di Masa Pandemi COVID-19 (Studi Kasus PT. Ciomas Adisatwa Maros)
Authors: Fitriani Ika , Mirnawati Mirnawati , Amin Muh , Risal Muhammad , Rahmi Nur 
Published: September 2024

Rumah potong ayam (RPA) PT. Ciomas Adisatwa Maros merupakan salah satu perusahaan perunggasan yang bergerak di bidang industry pemotongan unggas yang telah menggunakan teknologi moderen sesuai SNI. Tujuan penelitian ini untuk mengetahui mendeskripsikan strategi pemasaran karkas ayam broiler di masa pandemi covid 19 pada PT. Ciomas Adisatwa Maros. Jenis penelitian yang digunakan adalah penelitian deskriptif. Untuk memperoleh data menggunakan metode wawancara, observasi, dan dokumentasi. Analisis data menggunakan reduksi data, penyajian data, dan penarik kesimpulan. Melalui metode deskriptif analisis peneliti berusaha memaparkan secara jelas berdasarkan hasil penelitian yang telah dilaksanakan.
Berdasarkan hasil penelitian menunjukkan bahwa penerapan bauran pemasaran yang meliputi Produk yang dijual di PT. Ciomas Adisatwa Maros merupakan karkas ayam broiler yang dijual kepada konsumen. Saluran distribusi karkas ayam broiler di PT. Ciomas Adisatwa Maros melalui 3 lembaga yaitu pedagang besar, pedagang kecil, konsumen, harga karkas ayam broiler di PT. Ciomas Adisatwa Maros menetapkan harga sesuai kualitas ayamnya dan promosi karkas ayam broiler di PT. Ciomas Adisatwa Maros dilakukan melalui SMS, telepon, media sosial online atau pedagang yang langsung datang ke perusahaan.
Challenges Facing Juvenile Delinquent Rehabilitation Institutions in Palestine Considering the Sustainable Development Goals
Authors: Al-Rantisi Ahmed Mohammed , Abuiyada Reem Abdulmotaleb , Tabook Ali Suhail , Kandil Mohamed Mohamed 
Published: September 2024

Introduction: A widespread occurrence, juvenile delinquency affects children's development and poses a serious threat to society. Despite being a global problem, its impacts are more noticeable in developing countries like Palestine, since there are not enough resources to help them recover from it.

Objective: therefore, the current study was designed to determine the challenges facing juvenile delinquent rehabilitation institutions in Palestine.

Method: In this study, the quantitative approach to data collection and analyses was used. Questionnaires were used in data collection after testing their validity and reliability. The target population was all juvenile delinquents with a number of 55 and all social workers at Al-Rabie Foundation for juvenile care of Gaza and their number 14, data were collected during August 2023. The data were tabulated, and frequency distribution tables were prepared. descriptive statistics were used to analyse the data by statistical analysis SPSS version 26 statistical analysis programme.

Results and Discussion: The results of the study showed that the Palestinian government in Gaza should renovate the Al-Rabie Foundation to its full potential, this should involve both infrastructure and personnel development, and adequate funds should be made available to meet the basic needs of juvenile delinquents such as food, clothing, and cleanliness.
Analysis of Saudi Arabia's Legislative Reforms to Strengthen Compliance with The Convention on the Rights of the Child and SDGS: Enhancing Online Protection for Future Generations
Authors: Abobaker Mohammed Yahya 
Published: September 2024

Objectives: The goals of this research are to examine and review the recent law changes implemented by Saudi Arabia regarding the safeguarding of children from online dangers and determine their consistency with the International Convention on the Rights of the Child and sustainable development goals (SDGs).

Method: The study utilizes a comparative analytical methodology, examining legal literature and international conventions pertaining to child rights and assessing Saudi law articles and recent revisions.

Results and Discussions: The findings suggest that latest legislative changes in Saudi Arabia have enhanced the safeguarding of children's rights and achieved a higher level of compliance with international agreements and SDGs. Furthermore, it is crucial to promote collaboration between governmental and non-governmental organizations to provide comprehensive support to children in terms of their rights and protection from online risks, considering the rapid advancements in technology.

Research Implications: The investigation emphasizes the significance of regularly updating legislation to keep up with technological progress. It also stresses the necessity of combining legal frameworks with educational programs and media campaigns to safeguard children in the digital era.

Originality or Value: The present study offers a comprehensive examination of the legal changes made in Saudi Arabia to safeguard children from online dangers and assesses how well these changes match with global norms. The statement emphasizes the significance of incorporating legislation, media, and education in order to tackle the digital difficulties that children encounter.
Analysis of Kuttab School Curricula Using the Cipp Framework: A Social and Environmental Management Perspective
Authors: Jiyanto  , Waston  , Hidayat Syamsul , Ariyani Sekar Ayu , Rosyadi Imron , Widiani Desti 
Published: September 2024

Objective: This study aims to analyze the curricula of Kuttâb schools through the CIPP framework, focusing on the social and environmental management aspects of these educational programs. The research investigates how the "Iman Curriculum" and "Qur'an Curriculum" of Kuttâb Ibnu Abbas Surakarta diverge from mainstream Islamic education and evaluates their effectiveness from a social and environmental perspective.

Theoretical Framework: The analysis is grounded in the CIPP (Context, Input, Process, Product) model by Stufflebeam, which provides a structured approach to assess educational programs. This framework is employed to evaluate the curriculum's alignment with community needs, resource utilization, teaching methods, and educational outcomes, incorporating social and environmental management considerations.

Method: A qualitative evaluative design was used, involving interviews, observations, and document analysis. Data collection focused on understanding the development, implementation, and impact of the Kuttâb curricula, with particular attention to their social and environmental dimensions.

Results and Discussion: The study finds that Kuttâb Ibnu Abbas’s curricula are rooted in a grassroots model, distinct from conventional international curricula. The program is effective in addressing community needs but requires better alignment with individual student needs. While teaching methods are well-implemented, there is a need for improved teacher training and assessment practices. The study also discusses how the curricula's social and environmental management aspects could be enhanced to better serve both students and the community.

Research Implications: The findings provide actionable insights for improving the effectiveness of Kuttâb school curricula. Recommendations include better alignment with student needs, enhanced teacher training, and more robust assessment methods, alongside considerations for social and environmental impacts.

Originality/Value: This research is novel in applying the CIPP framework to the evaluation of Kuttâb school curricula from a social and environmental management perspective. It offers valuable insights into how alternative Islamic education models can be assessed and improved, contributing to the broader field of educational management and curriculum development.
Ancient Indian Mathematician - Baudhayana and The Value of √2
Authors: Nayana Joshi  , Samarth Joshi  
Published: September 2024

Baudhayana was an ancient Indian mathematician and the author of Shulba Sutra and Shrauta Sutra. These Sutras were composed in the 8th-7th century BC, Baudhayana's Shulba Sutras contain theorems of early mathematics and geometry, including, the Pi value, the square root of 2, and a statement of the Pythagorean theorem. One of his notable achievements of Baudhayana was the estimation of the square root of 2. According to his method, one can find, approximate value of the square root of 2 with remarkable accuracy. Baudhayana’s approach demonstrates a sophisticated understanding of numerical approximations and shows that ancient Indian mathematicians had advanced techniques for solving complex mathematical problems.
Effect of 4 Weeks Upper Extremity Plyometric Versus Free Weight Exercise On Shoulder Power and Strength in Cricket Players: An Experimental Study
Authors: Dr.RiyaKanubhai Patel (PT)  , Dr.Bhavik Jhaveri  , Riya Kanubhai Patel  
Published: September 2024

Background: Bowling action is explosive in nature; whereby a large amount of force must be generated over a very short period of time. Cricket bowlers are at the greatest risk of shoulder injury. The purpose of plyometric training is to increase the excitability of the neurological receptors for improved reactivity of the neuromuscular system. Overhead activities necessitate elastic loading to produce maximal, explosive, concentric contraction. In addition to the neurophysiological stimulus, the positive results of plyometric exercise can also be attribute to the recoil action of elastic tissues. Aims & Objectives: To compare the effects of 4 weeks’ upper extremity plyometric and free weight exercise on shoulder power and strength in cricket players. Methods: Total 60 subjects were included in this study and were randomly divided in three groups. Group A performed plyometric exercise 2 days/week, Group B performed exercises with dumbbells and Thera Band for 3 days/week for 4 weeks. Result: Analysis of the present study was done using One-way ANOVA for between the group comparison and Repeated Measures ANOVA for within the group comparison. The results of between the group analysis showed statistically significant improvement in shoulder strength as p=0.03 while no significant difference found for power (p=2.517). Conclusion: This study concludes that 4 weeks of upper extremity plyometric exercise group showed significant improvement in upper extremity strength compared to free weight exercise group and control group while no significant improvement is found for upper extremity power between all the three groups.