bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development and impact of heterotopic ossification in burns: a review of four decades of research
Authors: Kornhaber Rachel , Foster Nichola , Edgar Dale , Visentin Denis , Ofir Elad , Haik Josef , Harats Moti 
Published: March 2017

[Formula: see text] Introduction: Heterotopic ossification (HO) is the formation of lamellar bone within connective and other tissue where bone should not form and is a rare complication after burn injury. However, it leads to severe pain and distress, marked reduction in joint range of motion (ROM), impaired function and increased hospital length of stay. The pathophysiology, incidence and risk factors of HO remain poorly understood in burns and other traumas and the management, controversial. The aim of this comprehensive review, therefore, was to synthesise the available evidence on the development and treatment of HO after acute burn injury. Methods: The review was based on a systematic search of five electronic databases PubMed, EMBASE, CINAHL, LILACS and Scopus. Results: Synthesis and analysis of the data highlighted that, despite the passage of time, little translatable evidence is available to guide any prevention, screening, diagnostic or pharmacological or physical management protocols. Discussion: Causes of HO remain confounded, therefore prevention is difficult. Although spontaneous resolution is possible, surgical resection remains the recommended treatment when ROM and activities of daily living are severely affected. Conclusion: The findings from this review indicate that multicentre data pooling is needed to understand the optimum pathway to prevention, identification and treatment of HO in acute burn patients.
Recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 13–15 November 2016
Authors: Ahmed Niaz , Steiner Thorsten , Caso Valeria , Wahlgren Nils ,   for the ESO-KSU session participants
Published: March 2017

About the meeting: The purpose of the European Stroke Organisation (ESO)-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. Several scientific sessions discussed in the meeting and each session produced consensus statements. The meeting started 20 years ago as Karolinska Stroke Update, but since 2014, it is a joint conference with ESO. Importantly, it provides a platform for discussion on the ESO guidelines process and on recommendations to the ESO guidelines committee on specific topics. By this, it adds a direct influence from stroke professionals otherwise not involved in committees and work groups on the guidelines procedure. The discussions at the conference may also inspire new guidelines when motivated. The topics raised at the meeting are selected by the scientific programme committee mainly based on recent important scientific publications. The ESO-Karolinska Stroke Update consensus statement and recommendations will be published every 2 years and it will work as implementation of ESO-guidelines Background This year’s ESO-Karolinska Stroke Update Meeting was held in Stockholm on 13–15 November 2016. There were 10 scientific sessions discussed in the meeting and each session produced a consensus statement ( Full version with background, issues, conclusions and references are published as web-material and at http://www.eso-karolinska.org/2016 and http://eso-stroke.org ) and recommendations which were prepared by a writing committee consisting of session chair(s), secretary and speakers and presented to the 312 participants of the meeting. In the open meeting, general participants commented on the consensus statement and recommendations and the final document were adjusted based on the discussion from the general participants. Recommendations (grade of evidence) were graded according to the 1998 Karolinska Stroke Update meeting with regard to the strength of evidence. Grade A Evidence: Strong support from randomised controlled trials and statistical reviews (at least one randomised controlled trial plus one statistical review). Grade B Evidence: Support from randomised controlled trials and statistical reviews (one randomised controlled trial or one statistical review). Grade C Evidence: No reasonable support from randomised controlled trials, recommendations based on small randomised and/or non-randomised controlled trials evidence.
Anand Patwardhan’s Chronicles of Socio-political Realities
Authors: Patwardhan Anand 
Published: March 2017

Probably India’s best-known documentary film-maker Anand Patwardhan, for close to four decades now, has been raking the country’s political consciousness through his films, which delve into the crux of India’s social and political lives. In this piece, the editors have put together, with Patwardhan’s permission, his writings from his blog ( http://patwardhan.com/wp/ ) on the state atrocities upon Dalits in Maharashtra, the protests through poems and songs by a young group of Dalit activists from Pune—the Kabir Kala Manch (KKM)—and the satyagraha for the freedom of expression by its leaders like Sheetal Sathe; on the Supreme Court judgment that failed the Narmada Bachao Andolan as well as the belief in the justice system, making irrelevant a whole body of evidence built by the Andolan over the years that underlined the huge financial and human costs of the Sardar Sarovar dam project; and on the whole climate of intolerance that was behind the attack on M. F. Husain for his depiction of Hindu goddess Saraswati. This piece also includes a commentary by Alex Napier on Patwardhan’s documentary of the Narmada Bachao Andolan, drawn from Patwardhan’s blog.  These are important social commentaries of our times.
Index case of acute myeloid leukemia in a family harboring a novel CEBPA germ line mutation
Authors: Ram Jodi , Flamm Gabrielle , Balys Marlene , Sivagnanalingam Umayal , Rothberg Paul G. , Iqbal Anwar , Myers Jason R. , Corbett Anthony , Ashton John M. , Mendler Jason H. 
Published: March 2017

Key PointsThe persistence of a CEBPA mutation at the time of complete remission warrants germ line analysis. Not all patients harboring germ line CEBPA mutations have a family history of AML.
Incremental structural modeling on sparse visual SLAM
Authors: Roberto Rafael A. , Uchiyama Hideaki , Lima João Paulo S. M. , Nagahara Hajime , Taniguchi Rin-ichiro , Teichrieb Veronica 
Published: March 2017

Abstract
This paper presents an incremental structural modeling approach that improves the precision and the stability of existing batch-based ones for sparse and noisy point clouds from visual simultaneous localization and mapping (SLAM). The main idea is to use the generating process of point clouds on SLAM effectively. First, a batch-based method is applied to point clouds that are incrementally generated from SLAM. Then, the temporal history of reconstructed geometric primitives is statistically analyzed to suppress incorrect reconstruction. The evaluation shows that both precision and stability are improved compared to an existing batch-based method, and the proposed method is suitable for real-time structural modeling.
From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins
Authors: Kourtzelis Ioannis , Mitroulis Ioannis , von Renesse Janusz , Hajishengallis George , Chavakis Triantafyllos 
Published: March 2017

Abstract
Integrins constitute a large group of adhesion receptors that are formed as heterodimers of α and β subunits. Their presence and activation status on the surface of leukocytes modulate a broad spectrum of processes in inflammation and immunity. This mini review critically outlines research advances with regard to the function of leukocyte integrins in regulating and integrating the onset and resolution of acute inflammation. Specifically, we summarize and discuss relevant, current literature that supports the multifunctional role of integrins and their partners. The latter include molecules that physically associate with integrins or regulate their activity in the context of the following: 1) leukocyte recruitment to an inflamed tissue, 2) recognition and phagocytosis of apoptotic neutrophils (efferocytosis), and 3) egress of efferocytic macrophages from the inflamed site to lymphoid tissues. The understanding of the fine-tuning mechanisms of the aforementioned processes by integrins and their functional partners may enable the design of therapeutic tools to counteract destructive inflammation and promote more efficient resolution of inflammation.
Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation
Authors: Peled Jonathan U. , Devlin Sean M. , Staffas Anna , Lumish Melissa , Khanin Raya , Littmann Eric R. , Ling Lilan , Kosuri Satyajit , Maloy Molly , Slingerland John B. , Ahr Katya F. , Porosnicu Rodriguez Kori A. , Shono Yusuke , Slingerland Ann E. , Docampo Melissa D. , Sung Anthony D. , Weber Daniela , Alousi Amin M. , Gyurkocza Boglarka , Ponce Doris M. , Barker Juliet N. , Perales Miguel-Angel , Giralt Sergio A. , Taur Ying , Pamer Eric G. , Jenq Robert R. , van den Brink Marcel R.M. 
Published: March 2017

PurposeThe major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora are associated with GVHD, bacteremia, and reduced overall survival after allo-HCT. Because intestinal bacteria are potent modulators of systemic immune responses, including antitumor effects, we hypothesized that components of the intestinal flora could be associated with relapse after allo-HCT.MethodsThe intestinal microbiota of 541 patients admitted for allo-HCT was profiled by means of 16S ribosomal sequencing of prospectively collected stool samples. We examined the relationship between abundance of microbiota species or groups of related species and relapse/progression of disease during 2 years of follow-up time after allo-HCT by using cause-specific proportional hazards in a retrospective discovery-validation cohort study.ResultsHigher abundance of a bacterial group composed mostly of Eubacterium limosum in the validation set was associated with a decreased risk of relapse/progression of disease (hazard ratio [HR], 0.82 per 10-fold increase in abundance; 95% CI, 0.71 to 0.95; P = .009). When the patients were categorized according to presence or absence of this bacterial group, presence also was associated with less relapse/progression of disease (HR, 0.52; 95% CI, 0.31 to 0.87; P = .01). The 2-year cumulative incidences of relapse/progression among patients with and without this group of bacteria were 19.8% and 33.8%, respectively. These associations remained significant in multivariable models and were strongest among recipients of T-cell–replete allografts.ConclusionWe found associations between the abundance of a group of bacteria in the intestinal flora and relapse/progression of disease after allo-HCT. These might serve as potential biomarkers or therapeutic targets to prevent relapse and improve survival after allo-HCT.
Cancer Trends in Mexico: Essential Data for the Creation and Follow-Up of Public Policies
Authors: Mohar-Betancourt Alejandro , Reynoso-Noverón Nancy , Armas-Texta Daniel , Gutiérrez-Delgado Cristina , Torres-Domínguez Juan A. 
Published: March 2017

Purpose Cancer in a country like Mexico is a challenge for the current health system and for public health. However, the statistics about cancer in Mexico are scarce, so epidemiologic surveillance needs to be improved. The objectives of this article were to describe the extent of cancer and to estimate the national burden of cancer through 2020. Materials and Methods To meet this objective, an analysis of secondary official sources was performed. The cancer cases through 2020 were estimated on the basis of trends in mortality and the projection of incident cases reported by GLOBOCAN. Results In 2013, cancer was the cause of 12.84% of all deaths in Mexico. It is projected that the prevalence of cancer will be 904,581 by 2017 and will reach 1,262,861 by early in the next decade (ie, 2020). Conclusion Available data for cancer are incomplete. The development and implementation of population-based cancer registries in Mexico are essential. Assessment of the future outlook of cancer in Mexico will provide awareness of future challenges and can help health systems prepare to face them.
‘Refusing to Be a Man’: Gender, feminism and queer identity in the punk culture
Authors: Ambrosch Gerfried 
Published: March 2017

Abstract
Since its inception, transgressing heteronormative preconceptions of gender and sexuality a reaction to the prevalent ‘rock machismo’ of the 1970s, has been an important part of punk’s subversive repertoire. A number of first-wave punk artists deliberately blurred gender boundaries and toyed with signifiers pertaining to nonmainstream gender identities and sexual ‘perversion’ (consider, in this context, the common use of BDSM paraphernalia in early punk’s iconography). These transgressions had profound implications. As music journalist Lucy O’Brien puts it, ‘To find fresh meanings as a woman it was necessary to overturn the pastel shades of post-60s femininity and make an overt statement on a newly emerging, more aggressive understanding of female sexuality. Punk provided the perfect opportunity’. In the early 1990s, the feminist US punk rock group Bikini Kill, who spearheaded the riot grrrl movement, presented an assertive, unapologetic view of femininity, feminism and female sexuality, aggressively challenging male dominance in the punk milieu, where they were met sometimes with acceptance, sometimes with suspicion, and sometimes with open hostility. These developments notwithstanding, the anarchist periodical Rolling Thunder observes that ‘The average punk show is more dominated by patriarchy than a college class room’, and the transgender punk activist Alyssa Kai states, ‘[…] in reality, men run the scene, men are the scene, and men always have been and probably always will be at the center of the scene’. In other words, there is a gaping discrepancy within punk culture between egalitarian expectations, some of which verge on utopianism, and reality. ‘I think to anyone who is already slightly involved in punk and hardcore, it goes without saying that there is sexism in it’, says punk fan Lucy Hodges. Quite the same is true for homophobia.
Distributed join algorithms on thousands of cores
Authors: Barthels Claude , Müller Ingo , Schneider Timo , Alonso Gustavo , Hoefler Torsten 
Published: March 2017

Traditional database operators such as joins are relevant not only in the context of database engines but also as a building block in many computational and machine learning algorithms. With the advent of big data, there is an increasing demand for efficient join algorithms that can scale with the input data size and the available hardware resources.
In this paper, we explore the implementation of distributed join algorithms in systems with several thousand cores connected by a low-latency network as used in high performance computing systems or data centers. We compare radix hash join to sort-merge join algorithms and discuss their implementation at this scale. In the paper, we explain how to use MPI to implement joins, show the impact and advantages of RDMA, discuss the importance of network scheduling, and study the relative performance of sorting vs. hashing. The experimental results show that the algorithms we present scale well with the number of cores, reaching a throughput of 48.7 billion input tuples per second on 4,096 cores.
Cthrc1 lowers pulmonary collagen associated with bleomycin‐induced fibrosis and protects lung function
Authors: Binks Andrew P. , Beyer Megyn , Miller Ryan , LeClair Renee J. 
Published: March 2017

AbstractIdiopathic pulmonary fibrosis (IPF) involves collagen deposition that results in a progressive decline in lung function. This process involves activation of Smad2/3 by transforming growth factor (TGF)‐β and Wnt signaling pathways. Collagen Triple Helix Repeat‐Containing‐1 (Cthrc1) protein inhibits Smad2/3 activation. To test the hypothesis that Cthrc1 limits collagen deposition and the decline of lung function, Cthrc1 knockout (Cthrc1−/−) and wild‐type mice (WT) received intratracheal injections of 2.5 U/kg bleomycin or saline. Lungs were harvested after 14 days and Bronchoalveolar lavage (BAL) TGF‐β, IL1‐β, hydroxyproline and lung compliance were assessed. TGF‐β was significantly higher in Cthrc1−/− compared to WT (53.45 ± 6.15 ng/mL vs. 34.48 ± 11.05) after saline injection. Bleomycin injection increased TGF‐β in both Cthrc1−/− (66.37 ± 8.54 ng/mL) and WT (63.64 ± 8.09 ng/mL). Hydroxyproline was significantly higher in Cthrc1−/− compared to WT after bleomycin‐injection (2.676 ± 0.527 μg/mg vs. 1.889 ± 0.520, P = 0.028). Immunohistochemistry of Cthrc1‐/‐ lung sections showed intracellular localization and activation of β‐catenin Y654 in areas of tissue remodeling that was not evident in WT. Lung compliance was significantly reduced by bleomycin in Cthrc1−/− but there was no effect in WT animals. These data suggest Cthrc1 reduces fibrotic tissue formation in bleomycin‐induced lung fibrosis and the effect is potent enough to limit the decline in lung function. We conclude that Cthrc1 plays a protective role, limiting collagen deposition and could form the basis of a novel therapy for pulmonary fibrosis.
Vascular conductance and muscle blood flow during exercise are altered by inspired oxygen fraction and arterial perfusion pressure
Authors: Villar Rodrigo , Hughson Richard L. 
Published: March 2017

AbstractWe tested the hypothesis during the combined challenges of altered inspired O2 fraction (FIO2) and posture changes at lower power output regardless of body position that the vascular conductance (VC) recruitment to the exercising muscle would not limit muscle perfusion and estimated O2 delivery (DO2est). However, in head‐down tilt at the higher power output exercise in hypoxia, the recruitment of VC would have a functional limitation which would restrict muscle blood flow (MBF) leading to a limitation in DO2est with consequent increases in metabolic stress. Ten healthy volunteers repeated plantar flexion contractions at 20% (low power output = LPO) and 30% (higher power output = HPO) of their maximal voluntary contraction in horizontal (HOR), 35° head‐down‐tilt (HDT) and 45° head‐up‐tilt (HUT). Popliteal diameter and muscle blood flow velocity were measured by ultrasound determining MBF. VC was estimated by dividing MBF flow by MPP, and DO2est was estimated by MBF times saturation. LPOHUT in hypoxia was associated with no changes in VC and MBF leading to reduced DO2est. In LPOHDT under hypoxia, despite no apparent functional limitation in the VC recruitment, rise in MBF to maintain DO2est was associated with marked increase in muscle electromyographic activity, indicating greater metabolic stress. In HPOHDT under hypoxia, a functional limitation for the recruitment of VC constrained MBF and DO2est. Elevated muscle electromyographic signal in HPOHDT under hypoxia was consistent with challenged aerobic metabolisms which contributed to a greater increase in the relative stress of the exercise challenge and advance the onset of muscle fatigue.
Antibody‐mediated inhibition of EGFR reduces phosphate excretion and induces hyperphosphatemia and mild hypomagnesemia in mice
Authors: Ortega Bernardo , Dey Jason M. , Gardella Allison R. , Proano Jacob , Vaneerde Deanna 
Published: March 2017

AbstractMonoclonal antibody therapies targeting the EGF receptor (EGFR) frequently result in hypomagnesemia in human patients. In contrast, EGFR tyrosine kinase inhibitors do not affect Mg2+ balance in patients and only have a mild effect on Mg2+ homeostasis in rodents at elevated doses. EGF has also been shown to affect phosphate (Pi) transport in rat and rabbit proximal convoluted tubules (PCT), but evidence from studies targeting EGFR and looking at Pi excretion in whole animals is still missing. Thus, the role of EGF in regulating reabsorption of Mg2+ and/or Pi in the kidney remains controversial. Here, we inject mice with the anti‐EGFR monoclonal antibody ME‐1 for 2 weeks and observe a significant increase in serum Pi and mild hypomagnesemia, but no changes in Pi or Mg2+ excretion. In contrast, a single injection of ME‐1 resulted in hyperphosphatemia and a significant reduction in Pi excretion 2 days after treatment, while no changes in serum Mg2+ or Mg2+ excretion were observed. Dietary Mg2+ deprivation is known to trigger a rapid Mg2+ conservation response in addition to hyperphosphatemia and hyperphosphaturia. Interestingly, one dose of ME‐1 did not significantly modify the response of mice to 2 days of Mg2+ deprivation. These data show that EGFR plays a significant role in regulating Pi reabsorption in the kidney PCT, but suggest only a minor role in long‐term regulation of Mg2+ transport in the distal convoluted tubule.
The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy
Authors: Ericsson Anette , Tonelius Pernilla , Lal Mark , Sabirsh Alan , Böttcher Gerhard , William‐Olsson Lena , Strömstedt Maria , Johansson Camilla , Hyberg Gina , Tapani Sofia , Jönsson‐Rylander Ann‐Cathrine , Unwin Robert 
Published: March 2017

AbstractThe leptin‐deficient BTBRob/ob mouse develops progressive albuminuria and morphological lesions similar to human diabetic nephropathy (DN), although whether glomerular hyperfiltration, a recognized feature of early DN that may contribute to renal injury, also occurs in this model is not known. Leptin replacement has been shown to reverse the signs of renal injury in this model, but in contrast, the expected renoprotection by angiotensin‐converting enzyme (ACE) inhibition in BTBRob/ob mice seems to be limited. Therefore, to investigate the potential renal benefits of improved metabolic control in this model, we studied the effect of treatment with the dual peroxisome proliferator‐activated receptor (PPAR) α/γ agonist AZD6610 and compared it with the ACE inhibitor enalapril. AZD6610 lowered plasma glucose and triglyceride concentrations and increased liver size, but had no significant effect in reducing albuminuria, whereas enalapril did have an effect. Nephrin and WT1 mRNA expression decreased in the kidneys of BTBRob/ob mice, consistent with podocyte injury and loss, but was unaffected by either drug treatment: at the protein level, both nephrin and WT1‐positive cells per glomerulus were decreased. Mesangial matrix expansion was reduced in AZD6610‐treated mice. GFR, measured by creatinine clearance, was increased in BTBRob/ob mice, but unaffected by either treatment. Unexpectedly, enalapril‐treated mice showed intrarenal arteriolar vascular remodeling with concentric thickening of vessel walls. In summary, we found that the BTBRob/ob mouse model shows some similarities to the early changes seen in human DN, but that ACE inhibition or PPARα/γ agonism afforded limited or no kidney protection.