bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on the effects of 532 nm continuous laser combined with photodynamic therapy versus 595 nm pulsed dye laser on a chicken comb model of vascular malformation
Authors: Wei Ming-Lei , Zhang Hai-Yan , Wang Pei-Ru , Wang Bo , Shi Lei , Zhang Guo-Long , Wang Xiu-Li 
Published: July 2016

Abstract

Objective:
To explore the effects of 532 nm continuous laser combined with photodynamic therapy (PDT) versus 595 nm pulsed dye laser (PDL) on a chicken comb model of vascular malformation.

Study design:
Ninety adult male chickens were divided into three groups (A, B and C). One comb side of the chickens was taken randomly as the treatment side, and the other side as the self-control side. Group A was irradiated once with a 532 nm continuous laser after a single intravenous injection of hematoporphyrin monomethyl ether (HMME). In group B treatment side of combs was irradiated once with a 595 nm pulsed dye laser (PDL). In the control group C, the combs were treated neither with photosensitizer nor with irradiation.

Results:
Compared with the self-control sides, part of the treated combs were blanched after HMME-PDT while the histopathology showed an absence of erythrocytes and the vessel lumina were obliterated, leaving the normal overlying epidermis completely intact. At the same time selective destruction of the capillaries in the target area and obvious reduction of vascular vessel number were seen (p<0.01). In nine cases (30%) treatment was completely ineffective resulting in a total effective rate of 70% (21 cases). No scar formation was observed at all. After PDL treatment most of the treated combs were blanched while histopathology showed an absence of erythrocytes and the vessel lumina were obliterated, leaving the overlying epidermis with slight injuries and scabs. Here again, destruction of the capillaries in the target area and obvious reduction of vascular vessel number (p<0.01) were obtained. The total effective rate was 93% (28 cases); in two cases scars occurred. The combs of the control group showed no change compared with self-control sides (p>0.05).

Conclusion:
In the chicken comb model it was shown that both 532 nm HMME-PDT and 595 nm PDL treatment could damage capillaries in the superficial dermis of combs. The 532 nm HMME-PDT had fewer side effects compared with 595 nm PDL, but the inefficiency rate of 532 nm HMME-PDT group was higher than the 595 nm PDL group. No significant difference was observed in the macroscopic and histopathological results of both groups (p>0.05).
25 The Ethics of Whistleblowing
Authors: Hahn Henning 
Published: July 2016

Abstract
In this paper I outline a critical justification of the practice of political whistleblowing as exemplified by the case of Edward Snowden. At first, I argue that the question of justifiability cannot be settled with regard to absolutely binding principles such as special loyalties or the categorical duty to inform fellow citizens. What is required instead is the careful weighing of all relevant consequential and deontic reasons. However, this weighing process has to be publically justified. I will therefore turn to the theory of civil disobedience which provides us with two roots of public justification: widely accepted constitutional values and the primacy of public deliberation. In this view, political whistleblowing is to be seen as a special case of civil disobedience and can be justified along the lines of both liberal and republican approaches. However, in the end of the paper I will indicate that we have to transcend the state-based model of civil disobedience. Snowden’s acts of whistleblowing have a further cosmopolitan intention and need to be justified in terms of avant-garde principles of global justice.
Deep vein thrombosis, an unreported first manifestation of polyglandular autoimmune syndrome type III
Authors: Horsey M , Hogan P , Oliver T 
Published: July 2016

Summary
A 71-year-old woman with severe right lower leg pain, edema and erythema was presented to the Emergency Department and was found to have an extensive deep vein thrombosis (DVT) confirmed by ultrasound. She underwent an extensive evaluation due to her prior history of malignancy and new hypercoagulable state, but no evidence of recurrent disease was detected. Further investigation revealed pernicious anemia (PA), confirmed by the presence of a macrocytic anemia (MCV=115.8fL/red cell, Hgb=9.0g/dL), decreased serum B12 levels (56pg/mL), with resultant increased methylmalonic acid (5303nmol/L) and hyperhomocysteinemia (131μmol/L), the presumed etiology of the DVT. The patient also suffered from autoimmune thyroid disease (AITD), and both antithyroglobulin and anti-intrinsic factor antibodies were detected. She responded briskly to anticoagulation with heparin and coumadin and treatment of PA with intramuscular vitamin B12 injections. Our case suggests that a DVT secondary to hyperhomocystenemia may represent the first sign of polyglandular autoimmune syndrome III-B (PAS III-B), defined as the coexistent autoimmune conditions AITD and PA. It is important to recognize this clinical entity, as patients may not only require acute treatment with vitamin B12 supplementation and prolonged anticoagulation, as in this patient, but may also harbor other autoimmune diseases.

Learning points

A DVT can be the first physical manifestation of a polyglandular autoimmune syndrome.
Hyperhomocysteinemia secondary to pernicious anemia should be considered as an etiology of an unprovoked DVT in a euthyroid patient with autoimmune thyroid disease.
Patients with DVT secondary to hyperhomocysteinemia should undergo screening for the presence of co-existent autoimmune diseases in addition to treatment with B12 supplementation and anticoagulation to prevent recurrent thromboembolism.
Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair
Authors: Romero Noelle-Erin , Matson Steven W , Sekelsky Jeff 
Published: July 2016

Abstract
Repair of DNA damage is essential to the preservation of genomic stability. During repair of double-strand breaks, several helicases function to promote accurate repair and prevent the formation of crossovers through homologous recombination. Among these helicases is the Fanconi anemia group M (FANCM) protein. FANCM is important in the response to various types of DNA damage and has been suggested to prevent mitotic crossovers during double-strand break repair. The helicase activity of FANCM is believed to be important in these functions, but no helicase activity has been detected in vitro. We report here a genetic and biochemical study of Drosophila melanogaster Fancm. We show that purified Fancm is a 3ʹ to 5ʹ ATP-dependent helicase that can disassemble recombination intermediates, but only through limited lengths of duplex DNA. Using transgenic flies expressing full-length or truncated Fancm, each with either a wild-type or mutated helicase domain, we found that there are helicase-independent and C-terminal-independent functions in responding to DNA damage and in preventing mitotic crossovers.
Aspek Hukum Jaminan Fidusia
Authors: Yasir M. 
Published: July 2016

Abstract:Fiduciary guaranty was originally based on jurisprudence, as it became necessary to create legal certainty in secured lending. The object of fiduciary guaranty is immovable property as well as immovable property that can not be burdened with hypotheek. A person may obtain a fiduciary guaranty, must be made a Fiduciary Guaranty Certificate in front of Notary, then registered to the Fiduciary Registration Office. A criminal under fiduciary guaranty may be imposed on a person who intentionally falsifies, alters, omits or in any way misleads, if it is known by one of the parties not to bear fiduciary guaranty.Keywords: Guaranty, Fiduciary, Law. Abstrak: Jaminan fidusia pada awalnya hanya didasarkan pada yurisprudensi, karena menjadi kebutuhan untuk dapat terciptanya kepastian hukum dalam pinjaman dengan jaminan. Obyeknya adalah barang-barang tidak bergerak, disamping barang tidak bergerak yang tidak dapat dibebani hipoteek. Seseorang dapat memperoleh jaminan fidusia, harus dibuatkan Akte Jaminan Fidusia di depan Notaris, selanjutnya didaftarkan ke Kantor Pendaftaran Fidusia. Pidana dalam Jaminan Fidusia dapat dijatuhkan kepada orang yang dengan sengaja memalsukan, mengubah, menghilangkan atau dengan cara apapun memberikan keterangan secara menyesatkan, yang jika hal tersebut diketahui oleh salah satu pihak tidak melahirkan jaminan Fidusia.Kata Kunci: Jaminan, Fidusia, Hukum
Pemakzulan Kepala Daerah Di Era Otonomi Daerah Dalam Perspektif Politik dan Hukum; Analisis Kasus Prosesi Pemakzulan Bupati Garut Aceng Fikri
Authors: Aji Ahmad Mukri 
Published: July 2016

Abstract:The existence of regional autonomy in addition to provide fresh air to the regions in the area of creativity development, also had a negative impact by generating a small kings in the area plenipotentiary to the territory of the region, both in terms of mastery of their natural wealth and resources local opinion. Political processions that happen to Garut Regent Aceng Fikri least caused by several factors including; not harmonious and the outbreak of the internally between Aceng Fikri as Regent and Dicky Chandra as vice regent, the discovery of cases of marital lightning conducted by Aceng Fikri with Fany Oktora, the serious attention of state officials on the case conducted by Aceng Fikri, the establishment of the Special Committee of Parliament and Garut parliament plenary session, and the breakdown of law and law and moral ethics by Aceng Fikri.Keywords: Impeachment, Regional Head, Political LawAbstrak: Adanya otonomi daerah selain memberikan angin segar bagi daerah dalam kreatifitas pembangunan daerah, juga memberikan dampak negatif dengan memunculkan raja-raja kecil di daerah yang berkuasa penuh terhadap wilayah daerah, baik dari sisi penguasaan kekayaan alam dan sumber pendapat daerah. Prosesi politik yang terjadi pada diri Bupati Garut, Aceng Fikri setidaknya disebabkan oleh beberapa faktor di antaranya; tidak harmonis dan pecahnya secara internal antara Aceng Fikri sebagai Bupati dan Dicky Chandra sebagai wakil bupati, terbongkarnya kasus perkawinan kilat yang dilakukan oleh Aceng Fikri dengan Fany Oktora, adanya perhatian serius dari para pejabat negara terhadap kasus yang dilakukan oleh Aceng Fikri, pembentukan Pansus DPRD dan sidang paripurna DPRD Garut, dan adanya pelanggaran hukum dan perundang-undangan serta etika moral oleh Aceng Fikri. Kata Kunci: Pemakzulan, Kepala Daerah, Politik Hukum
Quality Measures to Assess Care Transitions for Hospitalized Children
Authors: Leyenaar JoAnna K. , Desai Arti D. , Burkhart Q. , Parast Layla , Roth Carol P. , McGalliard Julie , Marmet Jordan , Simon Tamara D. , Allshouse Carolyn , Britto Maria T. , Gidengil Courtney A. , Elliott Marc N. , McGlynn Elizabeth A. , Mangione-Smith Rita 
Published: July 2016

BACKGROUND:
Transitions between sites of care are inherent to all hospitalizations, yet we lack pediatric-specific transitions-of-care quality measures. We describe the development and validation of new transitions-of-care quality measures obtained from medical record data.

METHODS:
After an evidence review, a multistakeholder panel prioritized quality measures by using the RAND/University of California, Los Angeles modified Delphi method. Three measures were endorsed, operationalized, and field-tested at 3 children’s hospitals and 2 community hospitals: quality of hospital-to-home transition record content, timeliness of discharge communication between inpatient and outpatient providers, and ICU-to-floor transition note quality. Summary scores were calculated on a scale from 0 to 100; higher scores indicated better quality. We examined between-hospital variation in scores, associations of hospital-to-home transition quality scores with readmission and emergency department return visit rates, and associations of ICU-to-floor transition quality scores with ICU readmission and length of stay.

RESULTS:
A total of 927 charts from 5 hospitals were reviewed. Mean quality scores were 65.5 (SD 18.1) for the hospital-to-home transition record measure, 33.3 (SD 47.1) for the discharge communication measure, and 64.9 (SD 47.1) for the ICU-to-floor transition measure. The mean adjusted hospital-to-home transition summary score was 61.2 (SD 17.1), with significant variation in scores between hospitals (P &lt; .001). Hospital-to-home transition quality scores were not associated with readmissions or emergency department return visits. ICU-to-floor transition note quality scores were not associated with ICU readmissions or hospital length of stay.

CONCLUSIONS:
These quality measures were feasible to implement in diverse settings and varied across hospitals. The development of these measures is an important step toward standardized evaluation of the quality of pediatric transitional care.
A Logistic Normal Mixture Model for Compositional Data Allowing Essential Zeros
Authors: Bear John , Billheimer Dean 
Published: July 2016

The usual candidate distributions for modeling compositions, the Dirichlet and the logistic normal distribution, do not include zero components in their support. Methods have been developed and refined for dealing with zeros that are rounded, or due to a value being below a detection level. Methods have also been developed for zeros in compositions arising from count data. However, essential zeros, cases where a component is truly absent, in continuous compositions are still a problem.The most promising approach is based on extending the logistic normal distribution to model essential zeros using a mixture of additive logistic normal distributions of different dimension, related by common parameters. We continue this approach, and by imposing an additional constraint, develop a likelihood, and show ways of estimating parameters for location and dispersion. The proposed likelihood, conditional on parameters for the probability of zeros, is a mixture of additive logistic normal distributions of different dimensions whose location and dispersion parameters are projections of a common location or dispersion parameter. For some simple special cases, we contrast the relative efficiency of different location estimators.
GRAMSCI, ESCOLA UNITÁRIA E A FORMAÇÃO HUMANA
Authors: Zen Eliesér Toretta , Melo Douglas Christian Ferrari de 
Published: July 2016

O artigo tem como escopo refletir, do ponto de vista teórico, sobre a formação humana a partir da vida e obra do pensador italiano, Antonio Gramsci (1891-1937). Nesse sentido, objetiva abordar algumas categorias filosóficas de sua práxis político-pedagógica, entre elas, escola unitária, hegemonia e onilateralidade, como expressões de uma concepção teórica e política de um projeto socialista de sociedade e de ser humano. Nessa perspectiva, a escola unitária, ao integrar de forma dialética trabalho manual e intelectual, a dimensão técnica e política, autonomia intelectual e moral, conforma-se em princípio educativo do processo de formação humana. E, por fim, inaugura um autêntico humanismo em que o ser humano é compreendido como o conjunto das relações sociais, um ser concreto e histórico, um devir humano-social. Palavras-chave: Gramsci. Escola unitária. Formação humana. GRAMSCI, UNITARY SCHOOL AND HUMAN DEVELOPMENT Abstract: The scope of this article is to reflect from the theoretical point of view about the human formation on the basis of Antonio Gramsci's life and work (1891-1937). In this way, this text aims to address some philosophical categories of this Italian thinker's political and pedagogical praxis, such as Unitarian school, hegemony and omnilaterality. These expressions are instruments to build a political and theoretical conception of a socialist project of society and human being. On this perspective, the unitarian school, by integrating in a dialectic way the manual and intelectual job, the technical and political dimensions, the moral and intelectual autonomy, conforms it, in an educational principle of human's formation process. And finally, he inaugurates a authentic humanism in which human being is understood as a group of social relations, a be concrete and historical, a becoming social and human. Keywords: Gramsci. Unitarian school. Human Formation. GRAMSCI, ESCUELA UNITÁRIA Y FORMACIÓN HUMANAResumen: El artículo tiene como alcance reflejar desde el punto de vista teórico de la formación humana de la vida y el trabajo del pensador italiano Antonio Gramsci (1891-1937). En este sentido, tiene como objetivo hacer frente a algunas categorías filosóficas de su praxis político-pedagógica, entre ellos, la escuela unitaria, hegemonía y onilateralidade, como expresión de una concepción teórica y política de un proyecto socialista de la sociedad y del ser humano. Desde esta perspectiva, la escuela unitaria, mediante la integración del trabajo manual e intelectual dialécticamente, la dimensión técnica y política, autonomía intelectual y moral, se ajusta en principio educativo del proceso de desarrollo humano. Por último, inaugura un auténtico humanismo en el que el ser humano se entiende como un conjunto de relaciones sociales, un ser concreto y de la historia, convirtiéndose en un ser humano-social. Palabras clave: Gramsci. Escuela de unidad. Formación humana.
Comparative Study of Growth and Reproduction of Earthworm Eudrilus Eugeniae in Different Organic Substrate
Authors: Sonia V. , Felix S. , Antony Cheryl 
Published: July 2016

<div><p><em>Utilization of Bio-methanated Distillery Effluent (Spent Wash) as a potential substrate in vermiculture of Eudrilus eugeniae was studied at Advanced Research Farm Facility (ARFF) of Tamil Nadu Fisheries University, Madhavaram campus. The biological parameters of earthworm Eudrilus eugeniae were recorded when reared in different vermibeds treated with domestic waste (DW), crude spent wash (CSW) and diluted spent wash (DSW). Cow dung (CD) and leaf litter (LL) were used as base substrate material in all treatments. The experiment was conducted in perforated trays (45 x 30 x 10 cm) for a period of 10 weeks, in duplicates<strong>.</strong> Four number of non-clitellated adults (950-1025mg live weight) were introduced in each experimental unit. The experiment was conducted at an ambient temperature of 28-30°C. Growth parameters such as mean individual live weight, maximum individual growth rate (mg/worm/day), total biomass gain; reproductive performance indicators such as number of cocoons, reproduction rate (cocoon/worm/day) and hatching viability were significantly higher in vermibed treated with diluted spent wash. Mortality and growth retardation was observed in the vermibed treated with crude spent wash. To conclude, appropriately<strong> </strong>diluted spent wash can be used as a potential substrate in the vermiculture operation of Eudrilus eugeniae. </em></p></div>
The Glorious Days of Silk Trade in Malda District and Its Legacy
Authors: Simlandy Sagar 
Published: July 2016

<em>With its glorious traditional identity of Malda as a district is associated with the history of India for ages past. Malda is famous for its silk which claims credit for its familiarity in the whole India. Kautilya stated its glory in his ‘Arthosastha’. This sericulture has got its extreme in the district of Malda in the Ancient and Mediaeval times but it loses the glory due to Industrial Revolution in England. The East India Company has exported the Muslin of Malda in the entire World and made high profit that time. But the employer i.e. East India Company deprived the weavers of Malda in many forms to extract a high profit in silk trade. Eventually the weaver left the profession. As a result the production of Muslin was drastically reduced. Despite this deprivation and oppression, many weavers were engaged in that profession. Muslin weavers tried their best to make their product familiar throughout the country and outside the country. But they failed due to atrocities of the English East India Company. The Muslin was so famous that if it got its due patronage then it could be the forerunner of Industrial Revolution in India. Instead England got the Industrial Revolution in the Textile industry. The Article tries to emphasise the point and tries to explain reason behind it.</em>
Airborne Remote-Sensing Technologies Detect, Quantify Hydrocarbon Releases
Authors: Wilson Adam 
Published: July 2016

This article, written by Special Publications Editor Adam Wilson, contains highlights of paper OTC 25984, “Crosscutting Airborne Remote-Sensing Technologies for Oil and Gas and Earth Science Applications,” by A.D. Aubrey, C. Frankenberg, R.O. Green, M.L. Eastwood, and D.R. Thompson, National Aeronautics and Space Administration Jet Propulsion Laboratory, California Institute of Technology, and A.K. Thorpe, University of California, Santa Barbara, prepared for the 2015 Offshore Technology Conference, Houston, 4–7 May. The paper has not been peer reviewed.
Airborne imaging spectroscopy has evolved dramatically since the 1980s as a robust remote-sensing technique used to generate 2D maps of surface properties over large areas. Two recent applications are particularly relevant to the needs of the oil and gas sector and government: quantification of surficial hydrocarbon thickness in aquatic environments and mapping atmospheric greenhouse-gas components. These techniques provide valuable capabilities for monitoring petroleum seepage and for detection and quantification of fugitive emissions.
Introduction
The Jet Propulsion Laboratory (JPL), a National Aeronautics and Space Administration (NASA) federally funded research-and-development center operated by the California Institute of Technology, has been a pioneer in optical remote sensing since the 1980s. JPL capabilities include expertise across all project phases, including sensor design and construction, airborne experiment execution, and data generation driven by science and customer needs. JPL has particular expertise in imaging spectroscopy, a passive method to interrogate objects or surfaces without physical contact. Such remote sensing has traditionally been applied to investigation of surface composition in terrestrial environments. These surface compositions are characterized by use of a spectral library that includes the surface-reflectance or emissivity fingerprints of constituent materials. Airborne imaging spectrometers provide a powerful method to survey wide spatial extents with high-performance surface characterization because of the wide contiguous spectral range at moderate spectral resolution. Novel quantitative methods have emerged recently for both atmospheric gases and surficial oil on water.