bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rem2 regulates distinct homeostatic mechanisms in visual circuit plasticity
Authors: Moore Anna R. , Richards Sarah E. , Kenny Katelyn , de Oliveira Royer Leandro , Chan Urann , Flavahan Kelly , Van Hooser Stephen D. , Paradis Suzanne 
Published: October 2017

SUMMARYActivity-regulated genes sculpt neural circuits in response to sensory experience. These calcium-sensitive genes generally fall into two categories: transcription factors and proteins that function at synapses. Yet little is known about activity-regulated, cytosolic proteins that transduce signals between the neuronal membrane and the nucleus. Using the visual system as a model, we investigated the role of the activity-regulated, non-canonical Ras-like GTPase Rem2 in vivo. We demonstrate that Rem2-/- mice fail to exhibit normal ocular dominance plasticity during the critical period. At the circuit level, cortical layer 2/3 neurons in Rem2-/- mice show deficits in both postsynaptic scaling up of excitatory synapses and misregulation of intrinsic excitability. Further, we reveal that Rem2 plays a novel, cell-autonomous role in regulating neuronal intrinsic excitability. Thus, Rem2 is a critical regulator of neural circuit function and distinct homeostatic plasticity mechanisms in vivo.HIGHLIGHTSRem2 is required in excitatory cortical neurons for normal ocular dominance plasticityRem2 regulates postsynaptic homoeostatic synaptic scaling upRem2 alters the intrinsic excitability of neurons in a cell-autonomous manner
Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling
Authors: Sugg Kristoffer B , Markworth James F , Disser Nathaniel P , Rizzi Andrew M , Talarek Jeffrey R , Sarver Dylan C , Brooks Susan V , Mendias Christopher L 
Published: October 2017

ABSTRACTPlatelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals. Using the hindlimb synergist ablation model of tendon growth, our objectives were to determine the role of PDGFR signaling in the adaptation of tendons subjected to a mechanical growth stimulus, as well as to investigate the biological mechanisms behind this response. We demonstrate that both PDGFRs, PDGFRα and PDGFRβ, are expressed in tendon fibroblasts, and that the inhibition of PDGFR signaling suppresses the normal growth of tendon tissue in response to mechanical growth cues due to defects in fibroblast proliferation and migration. We also identify that membrane type-1 matrix metalloproteinase (MT1-MMP) as an essential proteinase for the migration of tendon fibroblasts through their extracellular matrix. Furthermore, we report that MT1-MMP translation is regulated by PI3K/Akt signaling, while ERK1/2 controls post-translational trafficking of MT1-MMP to the plasma membrane of tendon fibroblasts. Taken together, these findings demonstrate that PDGFR signaling is necessary for postnatal tendon growth and remodeling, and that MT1-MMP is a critical mediator of tendon fibroblast migration and a potential target for the treatment of tendon injuries and diseases.
The Cultural Brain Hypothesis: How culture drives brain expansion, underlies sociality, and alters life history
Authors: Muthukrishna Michael , Doebeli Michael , Chudek Maciej , Henrich Joseph 
Published: October 2017

AbstractIn the last few million years, the hominin brain more than tripled in size. Comparisons across evolutionary lineages suggest that this expansion may be part of a broader trend toward larger, more complex brains in many taxa. Efforts to understand the evolutionary forces driving brain expansion have focused on climatic, ecological, and social factors. Here, building on existing research on learning, we analytically and computationally model the predictions of two closely related hypotheses: The Cultural Brain Hypothesis and the Cumulative Cultural Brain Hypothesis. The Cultural Brain Hypothesis posits that brains have been selected for their ability to store and manage information, acquired through asocial or social learning. The model of the Cultural Brain Hypothesis reveals relationships between brain size, group size, innovation, social learning, mating structures, and the length of the juvenile period that are supported by the existing empirical literature. From this model, we derive a set of predictions—the Cumulative Cultural Brain Hypothesis—for the conditions that favor an autocatalytic take-off characteristic of human evolution. This narrow evolutionary pathway, created by cumulative cultural evolution, may help explain the rapid expansion of human brains and other aspects of our species’ life history and psychology.
Non-B-form DNA structures mark centromeres
Authors: Kasinathan Sivakanthan , Henikoff Steven 
Published: October 2017

AbstractAnimal and plant centromeres are embedded in repetitive “satellite” DNA, but are thought to be epigenetically specified. To define genetic characteristics of centromeres, we surveyed satellite DNA from diverse eukaryotes and identified variation in <10-bp dyad symmetries predicted to adopt non-B-form conformations. Organisms lacking centromeric dyad symmetries had binding sites for sequence-specific DNA binding proteins with DNA bending activity. For example, human and mouse centromeres are depleted for dyad symmetries, but are enriched for non-B DNA and are associated with binding sites for the conserved DNA-binding protein CENP-B, which is required for artificial centromere function but is paradoxically non-essential. We also detected dyad symmetries and predicted non-B-form DNA structures at neocentromeres, which form at ectopic loci. We propose that centromeres form at non-B-form DNA because of dyad symmetries or are strengthened by sequence-specific DNA binding proteins. Our findings resolve the CENP-B paradox and provide a general basis for centromere specification.
The presence of academic journals on Twitter and its relationship with dissemination (tweets) and research impact (citations)
Authors: Ortega Jose Luis 
Published: October 2017

PurposeThe purpose of this paper is to analyze the relationship between dissemination of research papers on Twitter and its influence on research impact.Design/methodology/approachFour types of journal Twitter accounts (journal, owner, publisher and no Twitter account) were defined to observe differences in the number of tweets and citations. In total, 4,176 articles from 350 journals were extracted from Plum Analytics. This altmetric provider tracks the number of tweets and citations for each paper. Student’st-test for two-paired samples was used to detect significant differences between each group of journals. Regression analysis was performed to detect which variables may influence the getting of tweets and citations.FindingsThe results show that journals with their own Twitter account obtain more tweets (46 percent) and citations (34 percent) than journals without a Twitter account. Followers is the variable that attracts more tweets (ß=0.47) and citations (ß=0.28) but the effect is small and the fit is not good for tweets (R2=0.46) and insignificant for citations (R2=0.18).Originality/valueThis is the first study that tests the performance of research journals on Twitter according to their handles, observing how the dissemination of content in this microblogging network influences the citation of their papers.
Innovation capabilities in services: a multi-cases approach
Authors: Daniel Vanessa Marques , de Lima Mauricio Pozzebon , Ferrari Dambros Ângela Maria 
Published: October 2017

Purpose
Considering the importance of services and innovation for the modern economy and the peculiarities that differentiate services from tangible goods, the purpose of this paper is to better understand how, based on the capabilities approach, innovation takes place in services.

Design/methodology/approach
A qualitative multi-case study was conducted in five instances of innovation in the fitness market, using a semi-structured questionnaire as devised in Zawislak et al. (2014).

Findings
The results show that the traditional capabilities framework is limited in explaining service innovation, as there are many levels of intangibility and non-linearity in service provision. Cases show that it is not possible to think of capabilities linearly in the service context. The authors propose that capabilities overlap, and the results show that this is a more accurate way of describing service dynamics. An alternative framework is suggested based on field findings, and a set of propositions are made for future research.

Originality/value
For many years, services were perceived as non-innovative, complementary activities, geared mainly towards the production of goods. The value of this study is to investigate a topic (innovation) that is widely studied in the industrial sector in a service context, contributing to a largely unexplored field.
Academic patenting in Brazil: the role of academic inventors in PCT patent applications – 2002-2012
Authors: Silva Kelyane , Vasconcellos Alexandre Guimarães , Tonholo Josealdo , Godinho Manuel Mira 
Published: October 2017

Purpose
The purpose of this paper is to analyse the patenting activity of the Brazilian academic sector vis-à-vis the domestic business sector, taking into account the recent evolution of Brazil’s industrial policies. The paper differentiates between “university academic patents”, which are owned by the universities, and “non-university academic patents”, which despite being invented by academic staff are not owned by the universities.

Design/methodology/approach
The authors’ cross-checked information regarding the names of all inventors with Brazilian addresses in PCT patent applications in the Espacenet database with the names of researchers in the CVs available on the Lattes Platform of CNPq. The analysis specifically focussed on patent applications published in the PCT with Brazilian priority for the 2002-2012 period.

Findings
It was found that the Brazilian academic patents concentrate on science-based technology areas, especially in the Pharma Biotechnology domain. For a total of 466 patent applications with Brazilian priority in this field, 233 have academic inventors. Of those 233 academic applications, 66.1 per cent have universities as their owners, while the remaining 33.9 per cent are not owned by universities. Further, it was found that there are more Brazilian academic patents in the biotechnology sub-domain than those filed by the business sector.

Research limitations/implications
This research was based on the intersection of patent databases and the content available on the official curriculum base of Brazil (Lattes Platform, CNPq). Once the curricula information are voluntary, there are risks inherent reliability of this information.

Practical implications
This study allows us to identify more accurately which is the effective role of the Brazilian Academy in patents generation, revealing that a significant unaccounted deposits with personal inventors or companies’ ownership really have a academic contribution.

Originality/value
This paper shows that the academic sector plays a key role in Brazil’s international patenting activity, particularly in science-intensive technology domains, and it highlights the specific contribution of academic patents not owned by universities.
Innovation and development: a revision of the Latin American thought
Authors: Jasso Javier , Del Valle Maria del Carmen , Núñez Ismael 
Published: October 2017

Purpose
The purpose of this paper is to review the contributions of what has been established as Latin American thought, as science, technology, and innovation (STI) in Latin America have been strongly related to development.

Design/methodology/approach
The analysis method is based on the review of a group of Latin American and Latinoamericanista (Latin Americanist) authors who were selected on the basis of their contributions to the explanation and proposals of public policy related to STI. The following are some of the questions that guide the analysis. How much has STI in Latin American thought contributed to the development theory? Given the fact that there are other dominant mainstreams, can we say that Latin American thought is still relevant?

Findings
The main conclusion of this work is that Latin American thought is still applied to current Latin American development discussions. This can be proven by the creation of particular concepts and analytical frameworks such as structural heterogeneity, development styles, authentic and spurious competitiveness, Sabato’s Triangle, the centre-periphery model, and STI policy practices.

Originality/value
This paper gathered contributions and categorised them into three dimensions: state participation (intensity, composition), industrialisation as the impulse for development, and instruments and public policy actions that can be implemented or have already been implemented.
From Big Data to Big Impact: analytics for teaching and learning in higher education
Authors: Chaurasia Sushil S. , Frieda Rosin Anna 
Published: October 2017

Purpose
The purpose of this paper is to examine the applicability of Big Data in higher education institutions.

Design/methodology/approach
A qualitative research approach using semi-structured interviews was employed to get insights from 23 experts from the Indian higher education sector. Respondents included higher education specialists from information technology, administration and academicians from public and private funded institutions.

Findings
Based on competitive advantage and data complexity, four major application areas were identified for the use of Big Data in higher education. These application areas are reporting and compliance; analysis and visualization; security and risk mitigation; and predictive analytics.

Research limitations/implications
Qualitative methodology is suitable to explain constructs and relationships between constructs, but it does not explain the magnitude of the relationships. The lack of Big Data experts in higher education constrained the ability of this research by leading to repeated themes. Finally, including participants from other countries would have assisted further in generalizing the findings.

Originality/value
As both interest and reluctance persists about Big Data, it calls for the application across industries and cost-benefit analyses. A number of researchers have studied the use of Big Data in various fields associated with the applicability, the data availability, the cost, the competence, the privacy, the relevance and the ownership. Very few publications explicitly address the integrative use of Big Data in higher education. So the current study examines the applicability of Big Data analytics in higher education institutions.
Adoption of sustainable retrofit in UK social housing 2010-2015
Authors: Swan William , Fitton Richard , Smith Luke , Abbott Carl , Smith Liz 
Published: October 2017

Purpose
The Retrofit State of the Nation Survey has tracked the perceptions of social housing sector professionals’ views of retrofit since 2010. It has taken the form of three surveys conducted in 2010, 2013 and 2015. Here, the authors bring together the three surveys to specifically address the adoption and perceived effectiveness of retrofit technology in social housing projects. The purpose of this paper is to identify the changing perceptions of social housing professionals over a period of significant policy change within in the sector.

Design/methodology/approach
The research takes the form of a cross-sectional attitudinal, self-completion survey, covering sections considering the adoption levels and perceived effectiveness of different retrofit technologies. The target sample was medium to larger scale registered social housing providers. The surveys were conducted in 2010, 2013 and 2015.

Findings
In terms of effectiveness, the reliance on tried and tested technologies is apparent. Emerging or more complex technologies have declined in perceived effectiveness over the period. It is clear that social housing has adopted a wide range of technologies, and the larger providers, with whom this survey is undertaken, potentially represent a significant pool of UK retrofit experience.

Originality/value
The survey provides a record of the changing attitudes of social housing providers to specific technologies over the period of 2010-2015, which has seen significant changes in the energy and social housing policy. The findings show the link between policy instruments and adoption, with policy instruments mapping to adoption in the sector. Perceived effectiveness reflects a preference for more established technologies, an issue that is highlighted in the recent Bonfield Review.
“Another nice mess you’ve gotten me into” employers’ liability for workplace banter
Authors: Middlemiss Sam 
Published: October 2017

PurposeBanter has been defined in the Oxford Dictionary as “the playful and friendly exchange of playful remarks” [www.merriam-webster.com/dictionary/banter]. This suggests that it is a form of dialogue or conversation that is welcome, non-threatening and appreciated by the recipient. However, this is often not the case, and the purpose of this paper is to consider the legal rules dealing with banter where it is threatening, unwanted or oppressive to the recipient. Where there is a discriminatory aspect to the banter, the protection provided under equality law will be considered. Banter can be directed at workers with different characteristics (e.g. disability, age, religion, sex, race or sexual orientation), and this paper will consider discriminatory banter whatever the basis. The different types of dialogues falling under the term banter will be analysed and the extent to which legal protection is in place to deal with it will be considered. The statutory legal rules dealing with harassment and bullying in the UK are the most relevant to controlling workplace banter and accordingly will be given primary consideration. Finally, recommendations will be made for improving both management practice and the law in this area.Design/methodology/approachThe methodology used is a thorough review of secondary sources in the UK including relevant statutes and legal cases and research undertaken in this area.FindingsThere is a need for legislative change to protect victims of unwanted workplace banter.Research limitations/implicationsLegal and managerial solutions to a complex problem.Practical implicationsVery few sources of primary research.Originality/valueHighly original.
Registration of business and tax payment in Nkoranza North and South districts in Brong Ahafo region of Ghana
Authors: Adu Kofi Osei , Amponsah Stephen 
Published: October 2017

Purpose
This paper aims to examine the relationship between registration of business and tax payment among micro-business owners in Nkoranza South Municipal and Nkoranza North District in Ghana.

Design/methodology/approach
Interview schedule was used to collect information from 720 micro business owners who qualify for tax stamps. The study used correspondence analysis as the analytical tool.

Findings
The study found a significant association between registration of business and tax payment. The biplot also indicated that unregistered businesses and businesses registered with District Assembly only are more likely to evade tax than those registered with Ghana Revenue Authority.

Originality/value
In Ghana, for instance, owner of business is required by law to provide information on his/her business, himself/herself and partners (as the case may be) to the Registrar-General Department, and thereafter, the business should also be registered at the nearest Ghana Revenue Authority District Office. This regulation was enacted in 2005, and it is expected that this registration will help tax authority in tax collection, as they will have adequate knowledge about businesses in the area including the location of the businesses. However, after 10 years in existence of this regulation, the effect of this registration requirement on tax payment in Ghana is not known. It is this gap that the present study seeks to fill by looking at the relationship between registration of business and tax evasion in the Ghanaian informal sector.
Shari’ah and economics: a generalized system approach
Authors: Choudhury Masudul Alam , Hoque Muhammad Nazmul 
Published: October 2017

Purpose
This paper aims to open the gateway of methodological abstraction and its application in an Islamic perspective in a way that has not been carried out before in Islamic literature. That is because of the absence of ontological and epistemological inquiry in Islamic erudition for a long time now. In the case of the Shari’ah and its induction of socioeconomic studies, the span of intellection and application ought to be premised on the ontological, epistemological, phenomenological and continuity attributes derived from the monotheistic law. This takes the formalism of organic inter-causal unity of being and becoming between the complementary good choices of life. The ontological monotheistic law of unity of knowledge is referred to as Tawhid in the Qur’an. Empirical work is done in support of the argument presented in this paper.

Design/methodology/approach
This paper is a formal contribution in the direction of developing a model of well-being based on the methodology of unity of knowledge arising from the Tawhidi epistemic foundation. In this regard, a methodologically interrelated theoretical and empirically applied study is accomplished to test the argumentation and hypothesis of endogenous systemic embedding of inter-variable causality between Shari’ah and economic and financial issues.

Findings
In spite of the epistemic approach to explain the embedding model of interrelationship between Islamic law and details of the socioeconomic field, Islamic scholarship and practice in all fields have remained oblivious to its epistemic roots. Consequently, as presently understood, Shari’ah and economics and the various socio-scientific specifics, as of Islamic finance and financial and religious institutions in these areas, could not make a generalized model of social well-being, one that can be simulated by inter-variable causal relations.

Originality/value
The paper conveys a critical conceptual idea to debate the scope and approach of Islamic Law, Shari’ah, on economic matters. The system-oriented approach is used to formulate a systems theory of integration between Shari’ah and economics. The results of the approach implemented in this study constitute a major contribution of this paper to scholarship in general and acts as a critique of traditional Islamic thought with respect to Shari’ah and economics.