bluuebunny/crossref_metadata_2025_split huggingface dataset:
Keratokonusprogression im Seitenvergleich
Authors: Goebels Susanne , Eppig Timo , Seitz Berthold , Langenbucher Achim 
Published: May 2017

Zusammenfassung
Einleitung Keratokonus ist eine meist beidseitig, progredient verlaufende Hornhauterkrankung. Ziel dieser Arbeit ist es, die Progression des Keratokonus im intraindividuellen Seitenvergleich zu beurteilen.
Patienten und Methoden In dieser monozentrischen retrospektiven Studie wurde der Krankheitsverlauf anhand topografischer Daten von nicht operierten Keratokonuspatienten (n = 48) über einen Zeitraum von mindestens 2 Jahren untersucht. Sieben topografische Keratokonusindizes aus der Scheimpflug-Tomografie wurden herangezogen, um sowohl die Ausgangsbefunde als auch die Progression der Partneraugen miteinander zu vergleichen.
Ergebnisse Die mittlere Beobachtungszeit betrug 3,3 ± 0,9 Jahre. Die Ausgangsbefunde eines Augenpaars korrelierten nicht miteinander (p > 0,05). Zwischen Ausgangsbefund und Progression der einzelnen Indizes zeigte sich für alle Indizes eine negative Korrelation (p < 0,05). Progression und Alter korrelierten nur für den kleinsten Krümmungsradius der Hornhaut (Rmin, R = 0,376, p = 0,008) und den Index of Height Decentration (IHD, R = 0,291, p = 0,045) miteinander. Hinsichtlich der intraindividuellen Progression zeigte sich eine schwache Korrelation für den Index of Surface Variance (ISV, R = − 0,399, p = 0,005), Index of Vertical Asymmetry (IVA, R = − 0,291, p = 0,045) und Keratokonusindex (KI, R = 0,307, p = 0,038).
Schlussfolgerungen Die bekannte Asymmetrie der Augenpaare bei Keratokonus, die typisch für das Krankheitsbild ist, wurde bestätigt. Diese Studie legt nahe, dass die Progression des Keratokonus eines Auges unabhängig von der Progression des Partnerauges ist. In dieser kleinen Patientengruppe konnte eine Altersabhängigkeit der Progression nicht für alle Keratokonusindizes nachgewiesen werden.
Visceral Artery Aneurysms and Pseudoaneurysms: Retrospective Analysis of Interventional Endovascular Therapy of 43 Aneurysms
Authors: Ruhnke Hannes , Kröncke Thomas 
Published: May 2017

Purpose To evaluate the results of interventional endovascular therapy of incidental and symptomatic visceral artery aneurysms in the elective and emergency situation.
Materials and Methods 43 aneurysms in 38 patients (19 female, 19 male, mean age: 57 ± 16 years [18 – 82]) were treated between 2011 and 2015. The characteristics of the aneurysms (true vs. false aneurysm, size, etiology, location, symptoms) were considered. Furthermore, we evaluated the intervention with respect to technical success, embolic/occlusive agents used, therapy-associated complications and post-interventional follow-up.
Results 23 true aneurysms (maximum diameter: 22 ± 18 mm [11 – 67 mm]) and 20 false aneurysms (maximum diameter: 9 ± 33 mm [3 – 150 mm]) were evaluated. The splenic (n = 14) and renal arteries (n = 18) were most frequently affected. The etiology was most commonly degenerative-atherosclerotic (47 %) or iatrogenic post-operative (19 %). 18/48 interventions were performed due to active bleeding. False aneurysms were associated significantly more often with active bleeding (63 vs. 25 %, p = 0.012). 41/48 treatments were technically successful. Re-intervention was necessary 6 times. In 2 cases the endovascular approach did not succeed. There was a complication rate of 10 %, whereby only 4 minor and 1 major complications occurred. No patient suffered from permanent sequelae. Aneurysms were primarily treated by using coils and if necessary additional embolic agents (liquid embolic agent or vascular plugs) (75 %). In the follow-up period, reperfusion of treated aneurysms occurred at a rate of 7 % (n = 3).
Conclusion Interventional endovascular therapy of visceral artery aneurysms is safe and effective in the elective treatment of incidental aneurysms as well as in significantly more frequent hemorrhaging false aneurysms in the emergency situation.
Key points
Citation Format
Long-term outcomes after endoscopic ultrasound-guided ablation of pancreatic cysts
Authors: Choi Jun-Ho , Seo Dong , Song Tae , Park Do , Lee Sang , Lee Sung , Kim Myung-Hwan 
Published: May 2017

Abstract
Background and study aims The aim of this study was to investigate the long-term outcomes after endoscopic ultrasound (EUS)-guided pancreatic cyst ablation.
Patients and methods In a single-center, prospective study, 164 patients with pancreatic cysts underwent EUS-guided cyst ablation using ethanol with paclitaxel. The inclusion criteria were as follows: unilocular or oligolocular cysts; clinically indeterminate cysts that required EUS fine-needle aspiration; and/or cysts that grew during the observation period. Treatment response was classified as complete resolution, partial resolution, or persistent cyst, with < 5 %, 5 % – 25 %, and 25 % of the original cyst volume, respectively.
Results The median largest diameter of the cyst was 32 mm and the median volume was 17.1 mL. Based on cyst fluid analysis there were 71 mucinous cystic neoplasms, 16 serous cystic neoplasms, 11 intraductal papillary mucinous neoplasms, 3 pseudocysts, and 63 indeterminate cysts. Sixteen treated patients (9.8 %) had adverse events (1 severe, 4 moderate, and 11 mild). Treatment response was as follows: complete resolution in 114 (72.2 %), partial resolution in 31 (19.6 %), and persistent cysts in 13 (8.2 %). Twelve of the 13 patients with persistent cysts underwent surgery. During clinical and imaging follow-up (median 72 months, interquartile range 50 – 85 months) of the 114 patients with complete resolution, only two patients (1.7 %) showed cyst recurrence. Based on multivariate analysis, the absence of septa (odds ratio [OR] 7.12, 95 % confidence interval [CI] 2.72 – 18.67) and cyst size less than 35 mm (OR 2.39, 95 %CI 1.11 – 5.16) predicted complete resolution.
Conclusion Among patients with pancreatic cysts in whom complete resolution was achieved after EUS-guided cyst ablation, 98.3 % remained in remission at 6-year follow-up. Unilocular form and small cyst size were predictive of complete resolution. This treatment approach may be an effective and durable alternative to surgery.Trial registered at ClinicalTrials.gov (NCT 00689715).
HPLC-Based Activity Profiling for GABAA Receptor Modulators in Searsia pyroides Using a Larval Zebrafish Locomotor Assay
Authors: Moradi-Afrapoli Fahimeh , van der Merwe Hannes , De Mieri Maria , Wilhelm Anke , Stadler Marco , Zietsman Pieter , Hering Steffen , Swart Kenneth , Hamburger Matthias 
Published: May 2017

AbstractA dichloromethane extract from leaves of Searsia pyroides potentiated gamma aminobutyric acid-induced chloride currents by 171.8 ± 54% when tested at 100 µg/mL in Xenopus oocytes transiently expressing gamma aminobutyric acid type A receptors composed of α
1
β
2
γ
2s subunits. In zebrafish larvae, the extract significantly lowered pentylenetetrazol-provoked locomotion when tested at 4 µg/mL. Active compounds of the extract were tracked with the aid of HPLC-based activity profiling utilizing a previously validated zebrafish larval locomotor activity assay. From two active HPLC fractions, compounds 1 – 3 were isolated. Structurally related compounds 4 – 6 were purified from a later eluting inactive HPLC fraction. With the aid of 1H and 13C NMR and high-resolution mass spectrometry, compounds 1 – 6 were identified as analogues of anacardic acid. Compounds 1 – 3 led to a concentration-dependent decrease of pentylenetetrazol-provoked locomotion in the zebrafish larvae model, while 4 – 6 were inactive. Compounds 1 – 3 enhanced gamma aminobutyric acid-induced chloride currents in Xenopus oocytes in a concentration-dependent manner, while 4 – 6 only showed marginal enhancements of gamma aminobutyric acid-induced chloride currents. Compounds 2, 3, and 5 have not been reported previously.
Misty, Spellbound and the lost Gothic of British girls’ comics
Authors: Round Julia 
Published: May 2017

AbstractThis article is a case study of the 1970s British girls’ comicsSpellbound(DC Thomson, 1976–1977) andMisty(IPC, 1978–1980). These mystery anthology comics followed the more famous American horror comics from publishers like EC Comics - but were aimed at pre-teen girls. The article situates these comics with respect to Gothic critical theory and within the wider landscape of British girls’ comics. Firstly, it closely considers and compares the structure and content of their stories with respect to theories of the terror and horror Gothic. It discovers that both comics offer similar fare, with a subversive streak that undercuts established horror archetypes. The article then looks closely at both titles’ aesthetics and their use of the page to draw comparisons. It uses comics theory and Gothic cinematic theory to demonstrate that the appearance ofMistyis more strongly Gothic than the aesthetic ofSpellbound. Finally, it considers a selection of stories from both comics and analyses their common themes using Gothic critical theory. It argues that both comics rework Gothic themes into new forms that are relevant to their pre-teen and teenage readers. It concludes by summarising the study’s findings and suggesting that these comics offer a “Gothic for Girls” that is part cautionary tale and part bildungsroman. This article is published as part of a collection on Gothic and horror.
Arabidopsis
glycosylphosphatidylinositol-anchored protein LLG1 associates with and modulates FLS2 to regulate innate immunity
Authors: Shen Qiujing , Bourdais Gildas , Pan Huairong , Robatzek Silke , Tang Dingzhong 
Published: May 2017

Significance
Recognition of pathogen-associated molecular patterns (PAMPs) by the host immune system is essential for activation of innate immunity in plants and animals. In plants, the receptor kinase FLAGELLIN SENSING 2 (FLS2) recognizes flagellin, a PAMP from bacteria. Here, we found that the glycosylphosphatidylinositol (GPI)-anchored protein LORELEI-LIKE GPI-ANCHORED PROTEIN 1 (LLG1) associates with FLS2 and regulates plant immunity by modulating FLS2 accumulation and signaling. LLG1 functions as a chaperone and coreceptor of FERONIA, a key component in pollen reception and development. This work identifies a shared component for immunity and development, and indicates that modulation of receptor kinases by membrane-localized GPI proteins could be a general mechanism for plants to respond to environmental and developmental cues.
Information socialtaxis and efficient collective behavior emerging in groups of information-seeking agents
Authors: Karpas Ehud D. , Shklarsh Adi , Schneidman Elad 
Published: May 2017

Significance
From bacteria to humans, individual foraging has been a key example of complex behavior, often analyzed experimentally and theoretically, in terms of a trade-off between exploration and exploitation. Finding a source in a nonturbulent environment can be done by following the gradient of a signal, but in noisy environments, moving to maximize information about the source results in efficient searches. We present a model for group foraging, in which each agent aims to maximize its own information and minimize its informational overlap with others. The result is a highly efficient, robust, biologically plausible, and nearly optimal collective group behavior. This suggests information maximization from sensory and social sources as an optimization principle that can direct individual and group behavior.
Exceptional and rapid accumulation of anthropogenic debris on one of the world’s most remote and pristine islands
Authors: Lavers Jennifer L. , Bond Alexander L. 
Published: May 2017

Significance
The isolation of remote islands has, until recently, afforded protection from most human activities. However, society’s increasing desire for plastic products has resulted in plastic becoming ubiquitous in the marine environment, where it persists for decades. We provide a comprehensive analysis of the quantity and source of beach-washed plastic debris on one of the world’s remotest islands. The density of debris was the highest recorded anywhere in the world, suggesting that remote islands close to oceanic plastic accumulation zones act as important sinks for some of the waste accumulated in these areas. As global plastic production continues to increase exponentially, it will further impact the exceptional natural beauty and biodiversity for which remote islands have been recognized.
Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces
Authors: Song Sukho , Drotlef Dirk-Michael , Majidi Carmel , Sitti Metin 
Published: May 2017

Significance
In transfer printing, robotics, and precision manufacturing, adhesion-controlled grasping of complex 3D surfaces is very challenging because the adhesive must be soft enough to enable intimate contact under light pressure but stiff enough to support high load and fracture strength. We address this dilemma by replacing the adhesive with a pressurized microfiber array that enables independent control of 3D conformability and bond strength. This architecture exhibits enhanced and robust adhesion on various sizes of 3D and deformable surfaces. In contrast to other microfiber adhesives, it has the area scalability of the natural gecko footpad. These features suggest that the proposed soft-gripping system can outperform conventional adhesive systems for a broad range of surface shapes and length scales.
RNA primer–primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication
Authors: Spiering Michelle M. , Hanoian Philip , Gannavaram Swathi , Benkovic Stephen J. 
Published: May 2017

Significance
The lagging-strand polymerase sometimes begins the synthesis of a new Okazaki fragment prior to finishing the previous fragment, creating a gap between the Okazaki fragments. The mechanism and signal that initiate this behavior have not been definitively identified. We demonstrate that primer–primase complexes left on the lagging ssDNA from primer synthesis have a residence time similar to the timescale of Okazaki fragment synthesis and the ability to block holoenzymes synthesizing DNA and stimulate the dissociation of the holoenzyme, triggering polymerase recycling. The collision with primer–primase complexes triggering early polymerase recycling has distinct advantages over previously proposed “signals.” Modeling of repeated cycles of Okazaki fragment initiation reproduced experimental data, providing insights into Okazaki fragment initiation and overall functioning of DNA replisomes.
Plate tectonic regulation of global marine animal diversity
Authors: Zaffos Andrew , Finnegan Seth , Peters Shanan E. 
Published: May 2017

Significance
Understanding the processes that govern biodiversity is a central goal of biology. It has been hypothesized that global biodiversity is influenced by tectonically driven shifts in the arrangement of continental crust. We use globally distributed fossil data and quantitative analyses of shifting continental configurations in paleogeographic reconstructions to test this hypothesis. A significant component of the trajectory of marine animal diversity over the past 443 million years is attributable to the assembly and disassembly of the supercontinent Pangaea.
Effective control of complex turbulent dynamical systems through statistical functionals
Authors: Majda Andrew J. , Qi Di 
Published: May 2017

Significance
Turbulent dynamical systems characterized by both a high-dimensional phase space and a large number of instabilities are ubiquitous among complex systems in science and engineering, including climate, material, and neural science. Control of these complex systems is a grand challenge, for example, in mitigating the effects of climate change or safe design of technology with fully developed shear turbulence. In complex turbulent dynamical systems, it is impossible to track and control the large dimension of instabilities, which strongly interact and exchange energy, and new control strategies are needed. The goal here is to propose an effective statistical control strategy for complex turbulent dynamical systems based on a recent statistical energy principle and statistical linear response theory.
Macedonia outside “Macedonia”
Authors: Takovski Aleksandar , Markovikj Nenad 
Published: May 2017

Abstract
The name dispute between Republic of Macedonia and Greece manifests itself in Greece’s objections to the use of the noun “Macedonia” or the adjective “Macedonian” to refer to any other ethnicity, culture, tradition and history except Greek. In order to promote itself as a sole claimant to the name, Greece has constructed a discourse which legitimizes its exclusive right to it, while at the same time it delegitimizes such right to Macedonia. However, this discourse does not only deny Macedonia the right to the name but it also denies Macedonia the right to discuss identity issues, while at the same time it obliterates Macedonian presence in the discourse in any relation to the disputed term. In this respect, this study seeks to analyze the specific linguistic strategies underlying these discursive effects.
Recreational Postrelease Mortality of Lake Trout in Lakes Superior and Huron
Authors: Sitar Shawn P. , Brenden Travis O. , He Ji X. , Johnson James E. 
Published: May 2017

Abstract
The effectiveness of fishing regulations that result in the release of some angler-caught fish depends on accurate knowledge of the postrelease mortality of those individuals. In the Laurentian Great Lakes, Lake Trout Salvelinus namaycush are a major component of recreational fisheries; across large regions of the lakes, they are managed with length limit and daily quota regulations assuming a 15% postrelease mortality rate. Due to concerns regarding the accuracy of that rate, we conducted a tagging study to estimate Lake Trout postrelease mortality in Lakes Superior and Huron, and we examined environmental and fishing factors that influenced the return rates of tagged fish. The basic study design was to compare tag return rates between two groups: (1) a treatment group comprising fish that were caught and released by anglers; and (2) a control group comprising fish that were caught via trap net and released. Tag return rates for the angler-caught group were evaluated in relation to depth of capture, surface temperature at release (ST), fishing method, anatomical hook site, play time, handling time, and barotrauma. Tag return rates for angler-caught fish declined significantly with increasing ST; the other factors’ effects on tag return rates were generally small. For Lake Superior, model-averaged (Akaike's information criterion) postrelease mortality estimates incorporating ST were 15.0% (SE = 5.6%) at STs less than 10°C, 42.6% (SE = 3.0%) at STs of 10–16°C, and 43.3% (SE = 3.6%) at STs greater than 16°C. Model-averaged estimates for Lake Huron were 52.5% (SE = 26.8%) at STs less than 10°C, 45.2% (SE = 14.0%) at STs of 10–16°C, and 76.4% (SE = 5.4%) at STs greater than 16°C. Based on these findings, alternative fishery management regulations that limit recreational catch-and-release angling of Lake Trout in the Great Lakes may be prudent. Current management policies based on an assumed 15% postrelease mortality are likely underestimating the total numbers of Lake Trout that are removed by recreational anglers.
Received January 26, 2017; accepted April 29, 2017 Published online June 26, 2017
On groups of Hölder diffeomorphisms and their regularity
Authors: Nenning David , Rainer Armin 
Published: May 2017

We study the set

D

n
,
β

(

R

d

)

\mathcal D^{n,\beta }(\mathbb R^d)

of orientation preserving diffeomorphisms of

R

d

\mathbb R^d

which differ from the identity by a Hölder

C
0

n
,
β

C^{n,\beta }_0

-mapping, where

n
∈

N

≥
1

n \in \mathbb N_{\ge 1}

and

β
∈
(
0
,
1
]

\beta \in (0,1]

. We show that

D

n
,
β

(

R

d

)

\mathcal D^{n,\beta }(\mathbb R^d)

forms a group, but left translations in

D

n
,
β

(

R

d

)

\mathcal D^{n,\beta }(\mathbb R^d)

are in general discontinuous. The groups

D

n
,
β
−

(

R

d

)
:=

⋂

α
>
β

D

n
,
α

(

R

d

)

\mathcal D^{n,\beta -}(\mathbb R^d) := \bigcap _{\alpha > \beta } \mathcal D^{n,\alpha }(\mathbb R^d)

(with its natural Fréchet topology) and

D

n
,
β
+

(

R

d

)
:=

⋃

α
>
β

D

n
,
α

(

R

d

)

\mathcal D^{n,\beta +}(\mathbb R^d) := \bigcup _{\alpha > \beta } \mathcal D^{n,\alpha }(\mathbb R^d)

(with its natural inductive locally convex topology) however are

C

0
,
ω

C^{0,\omega }

Lie groups for any slowly vanishing modulus of continuity

ω
\omega

. In particular,

D

n
,
β
−

(

R

d

)

\mathcal D^{n,\beta -}(\mathbb R^d)

is a topological group and a so-called half-Lie group (with smooth right translations). We prove that the Hölder spaces

C
0

n
,
β

C^{n,\beta }_0

are ODE closed, in the sense that pointwise time-dependent

C
0

n
,
β

C^{n,\beta }_0

-vector fields

u
u

have unique flows

Φ
\Phi

in

D

n
,
β

(

R

d

)

\mathcal D^{n,\beta }(\mathbb R^d)

. This includes, in particular, all Bochner integrable functions

u
∈

L
1

(
[
0
,
1
]
,

C
0

n
,
β

(

R

d

,

R

d

)
)

u \in L^1([0,1],C^{n,\beta }_0(\mathbb R^d,\mathbb R^d))

. For the latter and

n
≥
2

n\ge 2

, we show that the flow map

L
1

(
[
0
,
1
]
,

C
0

n
,
β

(

R

d

,

R

d

)
)
→
C
(
[
0
,
1
]
,

D

n
,
α

(

R

d

)
)

L^1([0,1],C^{n,\beta }_0(\mathbb R^d,\mathbb R^d)) \to C([0,1],\mathcal D^{n,\alpha }(\mathbb R^d))

,

u
↦
Φ

u \mapsto \Phi

, is continuous (even

C

0
,
β
−
α

C^{0,\beta -\alpha }

), for every

α
>
β

\alpha > \beta

. As an application we prove that the corresponding Trouvé group

G

n
,
β

(

R

d

)

\mathcal G_{n,\beta }(\mathbb R^d)

from image analysis coincides with the connected component of the identity of

D

n
,
β

(

R

d

)

\mathcal D^{n,\beta }(\mathbb R^d)

.
Completion of the universal I–Love–Q relations in compact stars including the mass
Authors: Reina Borja , Sanchis-Gual Nicolas , Vera Raül , Font José A. 
Published: May 2017

Abstract
In a recent paper, we applied a rigorous perturbed matching framework to show the amendment of the mass of rotating stars in Hartle's model. Here, we apply this framework to the tidal problem in binary systems. Our approach fully accounts for the correction to the Love numbers needed to obtain the universal I–Love–Q relations. We compute the corrected mass versus radius configurations of rotating quark stars, revisiting a classical paper on the subject. These corrections allow us to find a universal relation involving the second-order contribution to the mass δM. We thus complete the set of universal relations for the tidal problem in binary systems, involving four perturbation parameters, namely I, Love, Q and δM. These relations can be used to obtain the perturbation parameters directly from observational data.