bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clustering-aided prediction of outcomes in patients with idiopathic pulmonary fibrosis
Authors: Wang Lijun , Wu Peitao , Liu Yi , Patel Divya C , Leonard Thomas B , Zhao Hongyu 
Published: October 2024

Abstract
Background
Blood biomarkers predictive of the progression of idiopathic pulmonary fibrosis (IPF) would be of value for research and clinical practice. We used data from the IPF-PRO Registry to investigate whether the addition of “omics” data to risk prediction models based on demographic and clinical characteristics improved prediction of the progression of IPF.

Methods
The IPF-PRO Registry enrolled patients with IPF at 46 sites across the US. Patients were followed prospectively. Median follow-up was 27.2 months. Prediction models for disease progression included omics data (proteins and microRNAs [miRNAs]), demographic factors and clinical factors, all assessed at enrollment. Data on proteins and miRNAs were included in the models either as raw values or based on clusters in various combinations. Least absolute shrinkage and selection operator (Lasso) Cox regression was applied for time-to-event composite outcomes and logistic regression with L1 penalty was applied for binary outcomes assessed at 1 year. Model performance was assessed using Harrell’s C-index (for time-to-event outcomes) or area under the curve (for binary outcomes).

Results
Data were analyzed from 231 patients. The models based on demographic and clinical factors, with or without omics data, were the top-performing models for prediction of all the time-to-event outcomes. Relative changes in average C-index after incorporating omics data into models based on demographic and clinical factors ranged from 1.7 to 3.2%. Of the blood biomarkers, surfactant protein-D, serine protease inhibitor A7 and matrix metalloproteinase-9 (MMP-9) were among the top predictors of the outcomes. For the binary outcomes, models based on demographics alone and models based on demographics plus omics data had similar performances. Of the blood biomarkers, CC motif chemokine 11, vascular cell adhesion protein-1, adiponectin, carcinoembryonic antigen and MMP-9 were the most important predictors of the binary outcomes.

Conclusions
We identified circulating protein and miRNA biomarkers associated with the progression of IPF. However, the integration of omics data into prediction models that included demographic and clinical factors did not materially improve the performance of the models.

Trial registration
ClinicalTrials.gov; No: NCT01915511; registered August 5, 2013; URL: www.clinicaltrials.gov.
MEF-AlloSite: an accurate and robust Multimodel Ensemble Feature selection for the Allosteric Site identification model
Authors: Ugurlu Sadettin Y. , McDonald David , He Shan 
Published: October 2024

AbstractA crucial mechanism for controlling the actions of proteins is allostery. Allosteric modulators have the potential to provide many benefits compared to orthosteric ligands, such as increased selectivity and saturability of their effect. The identification of new allosteric sites presents prospects for the creation of innovative medications and enhances our comprehension of fundamental biological mechanisms. Allosteric sites are increasingly found in different protein families through various techniques, such as machine learning applications, which opens up possibilities for creating completely novel medications with a diverse variety of chemical structures. Machine learning methods, such as PASSer, exhibit limited efficacy in accurately finding allosteric binding sites when relying solely on 3D structural information.Scientific ContributionPrior to conducting feature selection for allosteric binding site identification, integration of supporting amino-acid–based information to 3D structural knowledge is advantageous. This approach can enhance performance by ensuring accuracy and robustness. Therefore, we have developed an accurate and robust model called Multimodel Ensemble Feature Selection for Allosteric Site Identification (MEF-AlloSite) after collecting 9460 relevant and diverse features from the literature to characterise pockets. The model employs an accurate and robust multimodal feature selection technique for the small training set size of only 90 proteins to improve predictive performance. This state-of-the-art technique increased the performance in allosteric binding site identification by selecting promising features from 9460 features. Also, the relationship between selected features and allosteric binding sites enlightened the understanding of complex allostery for proteins by analysing selected features. MEF-AlloSite and state-of-the-art allosteric site identification methods such as PASSer2.0 and PASSerRank have been tested on three test cases 51 times with a different split of the training set. The Student’s t test and Cohen’s D value have been used to evaluate the average precision and ROC AUC score distribution. On three test cases, most of the p-values ($$< 0.05$$

<
0.05

) and the majority of Cohen’s D values ($$> 0.5$$

>
0.5

) showed that MEF-AlloSite’s 1–6% higher mean of average precision and ROC AUC than state-of-the-art allosteric site identification methods are statistically significant.
Inter-lung asymmetrical airway closure cause insufflation delay between lungs in acute hypoxemic respiratory failure
Authors: Rozé Hadrien , Bonnardel Eline , Gallo Eloise , Boisselier Clément , Khan Pierre , Perrier Virginie , Repusseau Benjamin , Brochard Laurent 
Published: October 2024

Abstract
Background
Electrical Impedance Tomography (EIT) can quantify ventilation in the two lungs and be used to measure the airway opening pressure (AOP) of each lung. Asymmetrical AOPs can cause inter-lung insufflation delay.

Objectives
To assess the relation between AOP asymmetry and inter-lung insufflation delay at different PEEP levels.

Methods
Patients with acute hypoxemic respiratory failure and airway closure were included. Low-flow pressure-volume curves and EIT signal were recorded during controlled ventilation and for some patients in pressure support ventilation.

Results
23 patients were studied, 22 patients had ARDS, 9 patients had asymmetrical airway closure with an AOP of 10 [6–13] cmH20 in the sicker lung (AOPsicker) vs. 5 [3–9, ] cmH20 in the healthier lung. During a low flow inflation, the inter-lung inflation delay was 0 [0-112]ms vs. 1450 [375–2400]ms in patients without or with asymmetrical AOPs, p < 0.0001. This delay was correlated to the difference of AOP between the 2 lungs, Spearman R2 = 0.800, p < 0.0001. During tidal ventilation, median delay was 0 [0–62] ms vs. 150 [50–355] ms in patients without vs. with asymmetry, p = 0.019. Setting PEEP at the crossing point of a decremental EIT-based PEEP trial decreased the inter-lung insufflation delay. During pressure support insufflation delay could still be measured and was reduced by increasing PEEP from 5 to 10 cmH2O in patient with asymmetrical lung injury.

Conclusion
In asymmetrical airway closure, titrating PEEP can minimize inter-lung insufflation delay and can be monitored by EIT. Reducing the delay and reducing ventilation asymmetry is also feasible during pressure support ventilation when low flow inflation curves cannot be performed.
Factors influencing sport persistence still represent a knowledge gap – the experience of a systematic review
Authors: Kovács Karolina Eszter , Szakál Zsolt 
Published: October 2024

AbstractInvestigating sport persistence can make a significant contribution to a thorough examination and understanding of the factors underlying an athlete’s activity, integrating physical activity, sports motivation and commitment. This systematic review aimed to detect the papers focusing on the factors influencing sport persistence following the levels of Bronfenbrenner’s and Bauman’s ecological models. Following the PRISMA guidelines, by the EBSCO Discovery Service Search Engine, 512 records were detected, of which 21 met the criteria. Factors influencing sport persistence show a huge variety. Individual factors and micro-system level were overrepresented. Meso- and macro-level factors are underrepresented and measured only with other (individual or micro-system level) factors. Most factors detected at the individual (e.g. gender, age, career-related variables and positive psychological factors), micro- (e.g. family, peers and coaches), meso- (e.g. climate), and macro-level (cultural, societal, and institutional influences) were positively correlated with sport persistence, i.e. supporting the persistent behaviour of the athletes regarding participating in one’s sporting activity. In conclusion, there is still room for further research concerning sport persistence. Including variables belonging to the meso- and macro-system and conducting longitudinal research should be considered which would allow us to better understand the nature of sport persistence.
Two unequal shots in the same hole: Statistical versus deterministic deconvolution
Authors: Ziolkowski Anton , Baeten Guido 
Published: October 2024

Determination of the source time function and earth impulse response for explosive source seismic reflection data is traditionally performed using predictive deconvolution, which assumes the reflection seismogram is the convolution of a minimum-phase wavelet with a white, random, stationary sequence of impulses. We compare this statistical method with a new deterministic method that uses two unequal shots close together in the same hole and assumes a seismogram is the convolution of a source time function with a Green’s function, plus noise. The seismograms from the two shots share essentially the same Green’s function to any receiver because the shots are close together. The Green’s function is estimated by deconvolving the two seismograms at a given receiver for the corresponding source time functions, which are modeled independently; source parameters are obtained by trial and error by minimizing the difference between the two estimates of the Green’s function. We test these competing theories using seismic reflection data acquired with two charges fired separately in the same hole into a receiver spread of 1178 bunched geophone groups at 10 m intervals: a 1 kg charge at 42 m depth and a 2 kg charge at 40 m depth. The criterion for a comparison of the theories is the similarity of the recovered impulse responses at any receiver. Each method recovers a wavelet, or source time function, for each shot and two estimates of the impulse response, or Green’s function, at each receiver. Green’s functions recovered from the two shots using the deterministic method are almost identical and are measurably more similar than the impulse responses recovered using predictive deconvolution. That is, the deterministic method is better. The resolution of explosive source seismic reflection data can now be significantly improved with the new method and minimal additional field effort of loading one extra charge per shot hole.
Severe Hypercalcemia in an Infant With Transient Disaccharidase Deficiency
Authors: Barron Carly , Novack Shira , Prendaj Erealda , Regelmann Molly O 
Published: October 2024

Abstract
A previously healthy 11-month-old, full-term female developed growth failure, feeding intolerance, and irritability starting at 10 months of age. She was found to have a serum calcium level of 3.75 mmol/L (15 mg/dL) (reference range, 2.13-2.62 mmol/L; 8.5-10.5 mg/dL), consistent with severe hypercalcemia. She had bilateral nephrocalcinosis. Hypercalcemia improved with intravenous fluid hydration, but calcium rose again once intravenous fluids were discontinued and while consuming a low-calcium diet. Laboratory tests for common causes of hypercalcemia were negative. Stool-reducing substances were positive on 2 occasions. Endoscopic biopsy confirmed low disaccharidase levels. Her diet was changed to disaccharide-free formula, and hypercalcemia resolved. Genetic testing for congenital disaccharidase deficiency was negative. After repeat endoscopy demonstrating improved disaccharidase levels, disaccharides were incrementally reintroduced to the diet and calcium levels remained normal. This case demonstrates that disaccharidase deficiency, a rare inborn error of metabolism associated with hypercalcemia, may be a transient cause of hypercalcemia. The mechanism of hypercalcemia remains unknown.
Natural ways of vitamin D supplementation – detailed evaluation of Cantharellus cibarius
Authors: Naruszewicz Maria , Midro Aleksandra , Cetnarowski Przemysław , Zagórski Karol , Kozik Mateusz , Skalksa-Dziobek Nina , Małagocka Weronika , Chybowska Karolina , Rozpłoch-Sapa Maria , Orłowski Mateusz , Szymański Maciej 
Published: October 2024

Introduction and purpose: In the past, fungi were considered a very low-value meal, however in modern literature, they are increasingly more frequently studied for their nutritional and medical properties. They are being currently reconsidered as an abundant source of nutrients that may be incorporated in diets of individuals of special medical needs, such as obese and diabetic patients. The purpose of this review is to evaluate one of the most common edible mushroom species, Cantharellus cibarius (girolle, golden chanterelle) for its health promoting properties with particular emphasis on its vitamin D content. It was of considerable importance for us to analyse the amount of vitamin D in the mentioned mushroom, as this micronutrient deficiency is fairly common in the human population.
Material and method: The available literature was reviewed as provided by PubMed database and Google Scholar, with the use of keywords.
State of knowledge: Golden chanterelle mushroom is a valuable source of proteins, mineral ingredients like potassium, phosphorus, magnesium, iron and calcium, while containing low amounts of sodium and fat. The mushroom is especially valuable for its rich content of vitamin D, ranging up to 63 μg/100g fresh weight.
Conclusions: This paper may help other scientists expand their research on golden chanterelle properties. Moreover, girolle, as naturally containing many pro-health metabolites, may serve as natural supplementation of microelements.
Relação família-escola de crianças imigrantes na educação infantil: o que as pesquisas (não) têm a dizer?
Authors: Dos Santos Márcia de Souza , Ruela Alves Rosimária Aparecida , Machado Erica Esch 
Published: October 2024

A era da imigração no mundo, marcadamente acentuada nas últimas décadas do século XX, parece ter se tornado, no início deste novo século, a era de uma crise migratória (GUIZARDI, 2019). Diante desse quadro, por certo, é preciso pensar, entre outras questões, na necessidade de assegurar o direito à educação às crianças de famílias imigrantes. Assim, partindo da perspectiva de reafirmação do direito à educação pública de qualidade socialmente referenciada, o presente texto tem como foco temático a imigração dentro da Educação Infantil, tendo como objetivo mapear a produção sobre as pesquisas desenvolvidas sobre Educação Infantil, família e imigração, a fim de tentar compreender o que os pesquisadores e pesquisadoras têm evidenciado em suas pesquisas. Para tanto, foi realizada uma revisão sistemática de literatura sobre o tema em repositórios de dissertações e teses consultadas no BTDT - Biblioteca Digital brasileira de Dissertações e Teses), na Universidade Federal de Minas Gerais - UFMG, no Repositório Institucional da Universidade Estadual de Minas Gerais - RIUEMG e nas teses e dissertações disponíveis no site do programa de pós-graduação da UEMG, de pesquisas realizadas nos últimos dez anos (2010-2020), mantendo diálogo com as revisões de literatura na mesma temática de Braga (2019) e Silva & Braga (2019). Os resultados revelam a escassez de trabalhos que contextualizam as permanências e rupturas promovidas pela presença de estudantes imigrantes nas escolas, principalmente para a Educação Infantil. Palavras-chave: Educação Infantil; educação para imigrantes; fluxos migratórios contemporâneos.
Security improvement for TWDM-PON utilizing blowfish cryptography
Authors: Abdulla Essam N. , Radhi Safa Salam , Rashid Fareed F. , Hussien Reem A. , Salih Mohammed Mejbel , Abass A. K. , Fadil Elaf A. 
Published: October 2024

Security issues with optical access networks (OANs) are increasing as the number of users has dramatically grown. To address this problem, a full-system division multiplexing in both the time and wavelength domains has been utilized in a passive optical network second-generation (TWDM-NG-PON2) system. A secure approach to transfer data was presented by implementing the blowfish algorithm for image encryption and decryption in the OAN. Simulation results indicate effective realization of a bidirectional fiber link at 40 km with a splitting ratio of 1:256. The minimum accepted receiver sensitivity is −30.9dBm for uplink and −33.9dBm for downlink, and a symmetric high capacity of 160 Gbps rate has been obtained. The proposed algorithm in TWDM-PON offers high security with large bandwidth and an advanced long-haul network that provides effective resource usage and reinforced network authenticity.
Prevalence and associated factors of dyslipidemia in elderly people: Results from the Ardakan Cohort Study on Ageing, Iran
Authors: Delbari Ahmad , Naderyan Feli Shadi , Amirabadizadeh Ali Reza , Niroomand Mahtab , Bidkhori Mohammad 
Published: October 2024

Background and objective
Dyslipidemia is a major modifiable factor in elderly people. The study objective was to assess the prevalence and associated risk factors of dyslipidemia among the Iranian population aged over 50.

Methods
This population-based cross-sectional study is part of the Iranian Longitudinal Study on Ageing conducted in Ardakan, Iran. In total, 5,197 participants aged over 50 years old were included through a stratified random sampling method. Dyslipidemia was defined in compliance with the Adult Treatment Panel III criteria. The Chi-square and independent sample t-test were used to compare categorical and quantitative variables, respectively. A logistic regression analysis was applied to determine associated factors of dyslipidemia.

Results
The mean age of the participants was 62.24±7.52. The prevalence of dyslipidemia was 68.85%. High levels of total cholesterol, triglyceride, low-density lipoprotein, and low level of high-density lipoprotein were seen among 9.74%, 24.66%, 5.54%, 19.20% of the participants, respectively. In addition, 66.05% of the study participants were under the treatment of lipid-lowering medications. Among the possible investigated risk factors of dyslipidemia, male gender (odds ratio (OR) = 0.56, 95% confidence interval (CI): 0.47, 0.68), waist circumference (OR = 1.03, 95%CI: 1.02, 1.04), diabetes mellitus (OR = 2.28, 95%CI: 1.96, 2.66), and hypertension (OR = 1.59, 95%CI: 1.38, 1.83) showed a statistically significant association (p<0.05).

Conclusion
Dyslipidemia is highly prevalent in Ardakanˈs older population. So, lipid management interventions are necessary for this population.
A pedagogical evaluation of an institution's digital assessment platform (DAP): Integrating pedagogical, technical and contextual factors
Authors: Slade Christine , Mahon Kathleen , Lynagh Jacqueline , McGrath Dominic , Sheppard Karen , Ahsan Syed Qasim Muhammad , Benson Karen 
Published: October 2024

An assessment for learning approach is foundational for student learning. The necessity to shift teaching and learning online as a response to COVID-19 has propelled digital assessment into the mainstream within higher education institutions. User experience is a common indicator of effectiveness of technologically enhanced initiatives; however, measuring the pedagogical impact of digital assessment initiatives has not been straightforward. This paper presents a pedagogical evaluation, incorporating staff and student perspectives, of a digital assessment platform (DAP) at a large Australian metropolitan university. Data were collected using surveys, interviews, focus groups and case studies and incorporated findings from student evaluations of courses and a student-staff partnership project. Results highlight strong pedagogical reasons for continuing the digital assessment initiative, while also identifying constraints and opportunities for improvement. The insights generated through this evaluation emphasise the importance of considering technical, pedagogical and contextual factors and the interplay between the factors. In a quality assurance climate, where the demand for this type of institution-wide evaluation is increasing, this study contributes an approach that addresses some of the complexities and challenges of evaluating digital assessment initiatives in higher education. Future research is needed to understand more fully the relationships between pedagogical and contextual factors when undertaking an evaluation.

Implications for practice or policy:

The DAP enabled the (re)design of authentic, inclusive, engaging and secure assessment tasks.
Educator support is critical in learning the system and creating assessment with high pedagogical merit.
Student familiarisation opportunities with using the DAP are beneficial.
The DAP’s longevity within the institution is crucial considering the significant effort required of educators and students.
Contextual influences blur understanding of pedagogical factors.
Betweenness isomorphisms in the plane — the case of a circle and points
Authors: Doležal Martin , Kolář Jan , Morawiec Janusz 
Published: October 2024

Abstract
Two subsets A, B of the plane are betweenness isomorphic if there is a bijection f : A → B such that, for every x, y, z ∈ A, the point f(z) lies on the line segment connecting f(x) and f(y) if and only if z lies on the line segment connecting x and y. In general, it is quite difficult to tell whether two given subsets of the plane are betweenness isomorphic.
We concentrate on the case when each of the sets A, B is of the form C ∪ D where C is a circle and D is a finite set. We fully characterize the betweenness isomorphism classes in the family of all circles with three collinear points inside. In particular, we show that there are only countably many isomorphism classes, for which we provide an algebraic description.
Trust and Safety work: internal governance of technology risks and harms
Authors: Shulruff Toby 
Published: October 2024

Abstract
Trust and Safety work mitigates certain social risks and harms of digital technologies. In a landscape that is only slowly establishing regulatory oversight mechanisms, Trust and Safety work performs a type of internal governance by attempting to mitigate disinformation, online harassment, extremism, and other harms accelerated or amplified by technology products and services. With origins in content moderation, Trust and Safety work now also includes product advice for online services and IRL (in real life) products. Attention to Trust and Safety work can complicate a monolithic view of what tech work is and who does it, as well as point to locations for intervention as we seek to promote Public Interest Technology in globally impactful sociotechnical systems.