bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation study of risk-reduction activities after personalized breast cancer education tool in the WISDOM study
Authors: Wang Tianyi , Che Mandy , Huilgol Yash S. , Keane Holly , Goodman Deborah , Soonavala Rashna , Ozanne Elissa , Shieh Yiwey , Belkora Jeffrey K. , Fiscalini Allison Stover ,   Athena Breast Health Network Investigators and Advocate Partners, Esserman Laura , van ‘t Veer Laura , Hiatt Robert , Tice Jeff , Ziv Elad , Blanco Amie , Tong Barry , Ross Katherine , Fiscalini Allison , Scheuner-Purcell Maren , Badal Kimberly , Rhoads Kim , Kaplan Celia , Yau Christina , Soonavala Rashna , Leggat-Barr Katherine , Lewis Tomiyuri , Choy Patricia , Goodman Steffanie , Sabacan Leah , Wimmer Kenneth , Adduci Kelly , Flores Stephanie , Firouzian Roxanna , Acerbi Irene , Naeim Arash , Wenger Neil , Thompson Carlie , Petruse Antonia , Stanton Annette , Borowsky Alexander , Stewart Skye , Howell Lydia , Anton-Culver Hoda , Park Hannah Lui , Goodman Deborah , Madlensky Lisa , LaCroix Andrea , Parker Barbara , Layton Tracy , Hogarth Michael , Hartman Sheri , DeRosa Diana , Pierce John , Kaster Andrea , Wernisch Jan , Olopade Olufunmilayo , Lancaster Rachael , Esserman James , Eklund Martin , Shieh Yiwey , Sepucha Karen , Lee Vivian , Heditsian Diane , Brain Susie , Morehead Dolores , Esserman Laura J. 
Published: October 2024

AbstractBreast cancer risk reduction strategies have been well-validated, but barriers remain for high-risk individuals to adopt them. We performed a study among participants with high risk of breast cancer to validate whether a virtual breast health decision tool impacted a participant’s willingness to start risk-reducing activities, identify barriers to adopting these strategies, and understand if it affects breast cancer anxiety. The study sample was 318 participants in the personalized (investigational) arm of the Women Informed to Screen Depending on Measures of risk (WISDOM) clinical trial. After reviewing the tool, these participants completed a feedback survey. We demonstrated that 15 (4.7%) women were taking endocrine risk reduction, 123 (38.7%) were reducing alcohol intake, and 199 (62.6%) were exercising. In the three-month follow-up survey of 109 respondents, only 8 of 61 (13.1%) women who considered endocrine risk reduction pursued it. In contrast, 11 of 16 (68%) participants who considered alcohol reduction pursued the activity, and 14 of 24 (58%) women who considered exercise followed through. Participants listed fear of side effects as the most common barrier to endocrine risk reduction. We also present further steps to be taken to improve the effectiveness of the Breast Health Decisions tool.
Extending the computational reach of a superconducting qutrit processor
Authors: Goss Noah , Ferracin Samuele , Hashim Akel , Carignan-Dugas Arnaud , Kreikebaum John Mark , Naik Ravi K. , Santiago David I. , Siddiqi Irfan 
Published: October 2024

AbstractQuantum computing with qudits is an emerging approach that exploits a larger, more connected computational space, providing advantages for many applications, including quantum simulation and quantum error correction. Nonetheless, qudits are typically afflicted by more complex errors and suffer greater noise sensitivity which renders their scaling difficult. In this work, we introduce techniques to tailor arbitrary qudit Markovian noise to stochastic Weyl–Heisenberg channels and mitigate noise that commutes with our Clifford and universal two-qudit gate in generic qudit circuits. We experimentally demonstrate these methods on a superconducting transmon qutrit processor, and benchmark their effectiveness for multipartite qutrit entanglement and random circuit sampling, obtaining up to 3× improvement in our results. To the best of our knowledge, this constitutes the first-ever error mitigation experiment performed on qutrits. Our work shows that despite the intrinsic complexity of manipulating higher-dimensional quantum systems, noise tailoring and error mitigation can significantly extend the computational reach of today’s qudit processors.
A soccer-based intervention improves incarcerated individuals’ behaviour and public acceptance through group bonding
Authors: Newson Martha , Peitz Linus , Cunliffe Jack , Whitehouse Harvey 
Published: October 2024

AbstractAs incarceration rates rise globally, the need to reduce re-offending grows increasingly urgent. We investigate whether positive group bonds can improve behaviours among incarcerated people via a unique soccer-based prison intervention, the Twinning Project. We analyse effects of participation compared to a control group (study 1, n = 676, n = 1,874 control cases) and longitudinal patterns of social cohesion underlying these effects (study 2, n = 388) in the United Kingdom. We also explore desistance from crime after release (study 3, n = 249) in the United Kingdom and the United States. As law-abiding behaviour also requires a supportive receiving community, we assessed factors influencing willingness to employ formerly incarcerated people in online samples in the United Kingdom and the United States (studies 4–9, n = 1,797). Results indicate that social bonding relates to both improved behaviour within prison and increased willingness of receiving communities to support re-integration efforts. Harnessing the power of group identities both within prison and receiving communities can help to address the global incarceration crisis.
Strain regulation retards natural operation decay of perovskite solar cells
Authors: Shen Yunxiu , Zhang Tiankai , Xu Guiying , Steele Julian A. , Chen Xiankai , Chen Weijie , Zheng Guanhaojie , Li Jiajia , Guo Boyu , Yang Heyi , Wu Yeyong , Lin Xia , Alshahrani Thamraa , Yin Wanjian , Zhu Jian , Wang Feng , Amassian Aram , Gao Xingyu , Zhang Xiaohong , Gao Feng , Li Yaowen , Li Yongfang 
Published: October 2024

AbstractPerovskite solar cells (pero-SCs) have undergone rapid development in the past decade. However, there is still a lack of systematic studies investigating whether the empirical rules of working lifetime assessment used for silicon solar cells can be applied to pero-SCs. It is believed that pero-SCs show enhanced stability under day/night cycling owing to the reported self-healing effect in the dark1,2. Here we find that the degradation of highly efficient FAPbI3 pero-SCs is much faster under a natural day/night cycling mode, bringing into question the widely accepted approach to estimate the operational lifetime of pero-SCs based on continuous-mode testing. We reveal the key factor to be the lattice strain caused by thermal expansion and shrinking of the perovskite during operation, an effect that gradually relaxes under the continuous-illumination mode but cycles synchronously under the cycling mode3,4. The periodic lattice strain under the cycling mode results in deep trap accumulation and chemical degradation during operation, decreasing the ion-migration potential and hence the device lifetime5. We introduce phenylselenenyl chloride to regulate the perovskite lattice strain during day/night cycling, achieving a certified efficiency of 26.3 per cent and a 10-fold improvement in the time required to reach 80% of peak efficiency (T80) under the cycling mode after the modification.
Forecasting urban water demand using different hybrid-based metaheuristic algorithms’ inspire for extracting artificial neural network hyperparameters
Authors: Zubaidi Salah L. , Al-Bugharbee Hussein , Alattabi Ali W. , Ridha Hussein Mohammed , Hashim Khalid , Al-Ansari Nadhir , Yaseen Zaher Mundher 
Published: October 2024

AbstractThis research offers a novel methodology for quantifying water needs by assessing weather variables, applying a combination of data preprocessing approaches, and an artificial neural network (ANN) that integrates using a genetic algorithm enabled particle swarm optimisation (PSOGA) algorithm. The PSOGA performance was compared with different hybrid-based metaheuristic algorithms’ behaviour, modified PSO, and PSO as benchmarking techniques. Based on the findings, it is possible to enhance the standard of initial data and select optimal predictions that drive urban water demand through effective data processing. Each model performed adequately in simulating the fundamental dynamics of monthly urban water demand as it relates to meteorological variables, proving that they were all successful. Statistical fitness measures showed that PSOGA-ANN outperformed competing algorithms.
Time series analysis of comprehensive maternal deaths in Brazil during the COVID-19 pandemic
Authors: Cambou Mary Catherine , David Hollie , Moucheraud Corrina , Nielsen-Saines Karin , Comulada Warren Scott , Macinko James 
Published: October 2024

AbstractThe effects of the COVID-19 pandemic on comprehensive maternal deaths in Brazil have not been fully explored. Using publicly available data from the Brazilian Mortality Information (SIM) and Information System on Live Births (SINASC) databases, we used two complementary forecasting models to predict estimates of maternal mortality ratios using maternal deaths (MMR) and comprehensive maternal deaths (MMRc) in the years 2020 and 2021 based on data from 2008 to 2019. We calculated national and regional standardized mortality ratio estimates for maternal deaths (SMR) and comprehensive maternal deaths (SMRc) for 2020 and 2021. The observed MMRc in 2021 was more than double the predicted MMRc based on the Holt-Winters and autoregressive integrated moving average models (127.12 versus 60.89 and 59.12 per 100,000 live births, respectively). We found persisting sub-national variation in comprehensive maternal mortality: SMRc ranged from 1.74 (95% confidence interval [CI] 1.64, 1.86) in the Northeast to 2.70 (95% CI 2.45, 2.96) in the South in 2021. The observed national estimates for comprehensive maternal deaths in 2021 were the highest in Brazil in the past three decades. Increased resources for prenatal care, maternal health, and postpartum care may be needed to reverse the national trend in comprehensive maternal deaths.
Improving treatment of people with gastro-esophageal reflux disease refractory to proton pump inhibitors
Authors: Labenz Joachim , Schoppmann Sebastian F. 
Published: October 2024

AbstractProton pump inhibitors (PPIs) are the main treatment recommended and used for gastro-esophageal reflux disease (GERD). However, they fail to control symptoms in a substantial proportion of patients who have PPI-refractory GERD, which is defined as persistent symptoms attributable to objective findings of gastro-esophageal reflux. There remains a lack of dedicated guidelines to direct the management of these patients, some of whom could benefit greatly from surgical treatment. Too often patients remain long-term on ineffective treatment or stop treatment with lack of active review often resulting in their dissatisfaction going unnoticed. Also, concerns over efficacy and side effects of surgical procedures can be off-putting for both patients and physicians. It has been suggested that response to PPIs is predictive of surgical outcome. In this Perspective article we instead recommend that the key determinant should be whether symptoms are caused by GERD. We also discuss the traditional and newer surgical treatment options for people with PPI-refractory GERD.
Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations
Authors: Pham Van-Cuong , Rödel Claudia Jasmin , Valentino Mariaelena , Malinverno Matteo , Paolini Alessio , Münch Juliane , Pasquier Candice , Onyeogaziri Favour C , Lazovic Bojana , Girard Romuald , Koskimäki Janne , Hußmann Melina , Keith Benjamin , Jachimowicz Daniel , Kohl Franziska , Hagelkruys Astrid , Penninger Josef M , Schulte-Merker Stefan , Awad Issam A , Hicks Ryan , Magnusson Peetra U , Faurobert Eva , Pagani Massimiliano , Abdelilah-Seyfried Salim 
Published: October 2024

AbstractCerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological pattern of gene expression. The downstream target genes that are activated by KLF2 are mostly unknown. Here we show that Chromobox Protein Homolog 7 (CBX7), component of the Polycomb Repressive Complex 1, contributes to pathophysiological KLF2 signaling during zebrafish cardiovascular development. CBX7/cbx7a mRNA is strongly upregulated in lesions of CCM patients, and in human, mouse, and zebrafish CCM-deficient endothelial cells. The silencing or pharmacological inhibition of CBX7/Cbx7a suppresses pathological CCM phenotypes in ccm2 zebrafish, CCM2-deficient HUVECs, and in a pre-clinical murine CCM3 disease model. Whole-transcriptome datasets from zebrafish cardiovascular tissues and human endothelial cells reveal a role of CBX7/Cbx7a in the activation of KLF2 target genes including TEK, ANGPT1, WNT9, and endoMT-associated genes. Our findings uncover an intricate interplay in the regulation of Klf2-dependent biomechanical signaling by CBX7 in CCM. This work also provides insights for therapeutic strategies in the pathogenesis of CCM.
The eROSITA Final Equatorial Depth Survey (eFEDS)
Authors: Nandra K. , Waddell S. G. H. , Liu T. , Buchner J. , Dwelly T. , Salvato M. , Shen Y. , Wu Q. , Arcodia R. , Boller Th. , Brunner H. , Brusa M. , Collmar W. , Comparat J. , Georgakakis A. , Grau M. , Hämmerich S. , Ibarra-Medel H. , Igo Z. , Krumpe M. , Lamer G. , Merloni A. , Musiimenta B. , Wolf J. , Assef R. J. , Bauer F. E. , Brandt W. N. , Rix H.-W. 
Published: October 2024

Context. During its calibration and performance verification phase, the eROSITA instrument aboard the Spectrum-RG satellite performed a uniform wide-area X-ray survey of approximately 140 deg2, known as the eROSITA Final Equatorial Depth Survey (eFEDS).
Aims. The primary aim of eFEDS is to demonstrate the scientific performance to be expected at the end of the eight–pass eROSITA all-sky survey. This survey will provide the first focussed image of the whole sky in the hard X-ray (>2 keV) bandpass. The expected source population in this energy range is thus of great interest, particularly for AGN studies.
Methods. We used a 2.3–5 keV selection to construct a sample of 246 point-like hard X-ray sources for further study and characterisation. These sources are classified as either extragalactic (∼90%) or Galactic (∼10%), with the former consisting overwhelmingly of AGN and the latter active stars. We concentrated our further analysis on the extragalactic AGN sample, describing their X-ray and multi-wavelength properties and comparing them to the eFEDS main AGN sample selected in the softer 0.2–2.3 keV band.
Results. The eROSITA hard band selects a subsample of sources that is a factor of more than ten brighter than the eFEDS main sample. The AGN within the hard population reach up to z = 3.2 but on the whole, they are relatively nearby, with median z = 0.34 compared to z = 0.94 for the main sample. The hard survey probes typical luminosities in the range log LX = 43–46. The X-ray spectral analysis shows significant intrinsic absorption (with log NH > 21) in ~20% of the sources, with a hard X-ray power law continuum with mean < Γ >= 1.83 ± 0.04, which is typical of AGN, but slightly harder than the soft-selected eROSITA sample. Around 10% of the hard sample show a significant ‘soft excess’ component. The sampled black hole mass distribution in the eFEDS broad-line AGN population is consistent with that of the deeper COSMOS survey that probes a higher redshift population. On the other hand, the Eddington ratios appear systematically lower, which is consistent with the idea that the decline in SMBH activity since z ∼ 1 is due to a reduction in the typical accretion rate, rather than a shift towards activity in lower-mass black holes.
Conclusions. The eFEDS hard sample provides a preview of what can be expected from the eRASS final survey in terms of data quality. This pilot survey indicates the power of eROSITA to shed new light on the demographics and evolution of AGN, and the potential for discovery of new and rare populations.
Spinal anesthesia for endoscopic submucosal dissection of large rectosigmoid lesions: Feasibility study
Authors: Bonura Giuliano Francesco , Biancheri Paolo , Rainer Joachim , Soriani Paola , Rodriguez de Santiago Enrique , Parrella Arianna , Campioli Alice , Guerra Emmanuele , Gualdi Eugenia , Pignatti Alessandro , Manno Mauro 
Published: October 2024

Abstract
Background and study aims Colorectal endoscopic submucosal
dissection (ESD) is often challenging and time-consuming. Prolonged sedation and general
anesthesia are associated with a relevant risk of anesthesia-related adverse events (ARAEs),
especially in elderly and frail patients. Spinal anesthesia (SA), a simple technique providing
analgesia and motor block without systemic drug administration, has never been described in
gastrointestinal endoscopy. We assessed the feasibility of SA in colorectal lesion ESD.
Patients and methods We retrospectively collected data on all consecutive patients who underwent ESD for colorectal laterally spreading tumors (LSTs) under SA in our center during the last 3 years. We evaluated the rates of technical success, i.e. ESD completion under SA without need of conversion to deep sedation or general anesthesia, and ARAEs after SA.
Results ESD under SA was performed on 20 rectosigmoid LSTs ≥ 35 mm. Technical success was achieved in 95.0% of cases (19/20), while one patient (5.0%) required conversion to deep sedation. Two patients (10.0%) experienced acute urinary retention that was successfully treated with temporary catheterization.
Conclusions Our initial experience suggests that SA for ESD of large rectosigmoid LSTs is feasible, and it may prove to be a valuable option, especially for elderly and frail patients.
Neuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium
Authors: Akuamoah-Boateng Gloria , Buttafuoco Kayla A. , Sutton Courtney C. , Hackett Brian P. 
Published: October 2024

In recent times, atypical antipsychotics are increasingly being used in the neonatal intensive care unit (NICU) for the management of neonatal delirium. As the recognition of delirium in NICU infants increases, caution should be exercised with use of antipsychotics for management, given associated adverse effects. Neuroleptic malignant syndrome (NMS) is a rare adverse drug reaction associated with exposure to antipsychotics and other antidopaminergic medications. Most reported cases of NMS in pediatric patients have been in older children on antipsychotic medications. We present a case of a 10-month-old former preterm infant who developed clinical signs suggestive of NMS after exposure to olanzapine for treatment of delirium. Our case report details the clinical course of this infant, delves into the condition, and outlines some useful lessons for the clinician in the identification and management of this rare but life-threatening adverse effect.
Key Points
A Convenient Synthesis of CHF2O-Containing Pyrrolidines and Related Compounds — Prospective Building Blocks for Drug Discovery
Authors: Levchenko Kostiantyn , Virstiuk Ivan , Menshykova Daria , Pokhodylo Nazariy 
Published: October 2024

AbstractFluorine-containing organic molecules, including CHF2O derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O motif incorporated with azetidine, pyrrolidine (proline), piperidine, 2-azabicyclo[2.2.1]heptane, and 8-azabicyclo[3.2.1]octane cores was synthesized. A multigram scale (10–30 g) procedure for synthesizing the title compounds from commercially available amino alcohols was studied.
Plasma discharge experiments of a Faraday shieldless driver for high-power and long-pulse radio frequency ion source for NBI application
Authors: Liu Bo , Peng Xufeng , Gu Yuming , Yang Yuwen , Li Yufan , Jiang Caichao , Liu Zhimin , Xie Yahong , Wei Jianglong 
Published: October 2024

Due to the high stability and less maintenance, the radio frequency (RF) driven ion source is preferred for the neutral beam injection (NBI) system. In a popular design of the RF ion source for NBI application, a Faraday shield (FS) is installed inside the RF plasma driver to protect the discharge tube. However, the FS also brings some drawbacks, such as lowering the RF power transfer and increasing the processing difficulty. A prototype of the RF plasma driver without FS and with mature manufacturing technology has been developed by using a water-cooled discharge tube. After basic testing, this prototype was further tested under the RF plasma discharge experiments in views of high power, long pulse, and long term. The reliability and its plasma characteristics were the focus of these experiments, also for the hidden issues. The results show that the prototype could generate stable and high-density plasma without any damage or sputtering mark. An RF plasma discharge of 50 kW and 20 s has been achieved. The expected frequency tuning was equally effective on the prototype. Moreover, compared to the RF plasma driver with FS, the prototype could produce higher electron density in the extraction region under the same RF power. Of course, some of the shortcomings of the prototype have also been exposed in the experiments and will be improved in subsequent experiments.
Toxicological consequences of polystyrene microplastics on Cirrhinus mrigala: effects on growth, body composition, nutrient digestibility, haematology and histopathology
Authors: Rashid Eram , Hussain Syed Makhdoom , Ali Shafaqat , Al-Ghanim Khalid A. , Sarker Pallab K. 
Published: October 2024

Context Microplastics (MPs), whether originating from primary or secondary means, have emerged as a significant global issue nowadays. Aims The current research was designed to assess the toxicological consequences of polystyrene MPs (PS-MPs) on the growth, digestibility, body composition, haematology and histopathology of Cirrhinus mrigala fingerlings. Methods In this study, six test diets with different MP concentrations were used, including a control group (0% MPs) and groups with 0.5, 1, 1.5, 2 and 2.5% MPs in sunflower meal-based diets. For a 90-day duration, 270 fingerlings (6.54 ± 0.02 g fish−1) were placed in triplicate groups in tanks, with each tank consisting of 15 fingerlings, feeding at a rate equivalent to 5% of their live wet bodyweight. Key results The findings revealed a negative correlation between MP concentration and fingerlings performance, encompassing growth, digestibility, body composition, histopathology and hematology. Conclusions The results indicate that 2.5% MPs inclusion in C. mrigala adversely affects growth, digestibility, body composition, histopathology and hematology. Implications This research highlights the harmful effects of PS-MPs on C. mrigala fingerlings, emphasising urgent global action to address and mitigate aquatic ecosystem threats.