bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory Bowel Disease and Risk of Ischemic Heart Disease: An Updated Meta‐Analysis of Cohort Studies
Authors: Feng Wan , Chen Guangxia , Cai Dawei , Zhao Song , Cheng Jiafei , Shen Hong 
Published: August 2017

Background
Several immune‐mediated diseases have been shown to be associated with an increased risk of cardiovascular disease. However, studies evaluating the association between inflammatory bowel disease and risk of cardiovascular disease reported inconsistent results. We assessed the association between inflammatory bowel disease and risk of ischemic heart disease in a meta‐analysis of cohort studies.

Methods and Results

We conducted a literature search of PubMed and Embase up to October 2016 to identify relevant studies. The summary relative risks were calculated using the random‐effects models. To explore the source of heterogeneity, we performed subgroup and sensitivity analysis. We included 10 cohort studies that satisfied our inclusion criteria
.
Patients with inflammatory bowel disease were associated with an increased risk of ischemic heart disease (relative risk: 1.244; 95%
CI
, 1.142–1.355). Considerable heterogeneity was observed. Crohn's disease showed a significantly increased risk of ischemic heart disease (relative risk=1.243; 95%
CI
, 1.042–1.482) and a positive association was also observed in ulcerative colitis (relative risk=1.206; 95%
CI
, 1.170–1.242).

Conclusions
Based on meta‐analysis of cohort studies, we found an increased risk of ischemic heart disease in patients with inflammatory bowel disease. Large long‐term prospective studies are warranted to confirm our results.
An integrative description of Ramazzottius subanomalus (Biserov, 1985 (Tardigrada) from Poland
Authors: STEC DANIEL , ZAWIERUCHA KRZYSZTOF , MICHALCZYK ŁUKASZ 
Published: August 2017

A population of Ramazzottius subanomalus (Biserov, 1985) was found in a moss sample collected from concrete wall in Poznań, western Poland. Animals were prepared for light and scanning electron microscopy and for DNA sequencing to provide an integrative description of the species that was originally described only by means of classical alpha taxonomy. As a result of our studies, we provide the first ever SEM photomicrographs of Ramazzottius subanomalus individuals and their buccal apparatuses. Additionally, we present new DNA sequences as well as new morphometric data for R. subanomalus. The molecular data comprise sequences for three DNA fragments, one mitochondrial (COI) and two nuclear (18S rRNA and 28S rRNA). As a result of being able to analyse a considerable number of animals and eggs, our study has expanded some of R. subanomalus morphometric traits ranges; compared with those provided in the original description. The spine-shaped egg processes as well as qualitative and quantitative characters of adults show R. subanomalus is most similar to Ramazzottius anomalus (Ramazzotti, 1962). However, our study has shown that R. subanomalus differs from R. anomalus by the lack of fine granulation on eggshell surface as well as by three other morphometric characters: longer buccal tube and two aspects of the placoids. We also discuss the validity of the R. anomalus record in Poland in the light of our findings. Finally, we show that the extreme eggshell variability in this species is observed both in natural and laboratory environments.
Temperature and Precipitation Variance in CMIP5 Simulations and Paleoclimate Records of the Last Millennium
Authors: Parsons Luke A. , Loope Garrison R. , Overpeck Jonathan T. , Ault Toby R. , Stouffer Ronald , Cole Julia E. 
Published: August 2017

Abstract
Accurate assessments of future climate impacts require realistic simulation of interannual–century-scale temperature and precipitation variability. Here, well-constrained paleoclimate data and the latest generation of Earth system model data are used to evaluate the magnitude and spatial consistency of climate variance distributions across interannual to centennial frequencies. It is found that temperature variance generally increases with time scale in patterns that are spatially consistent among models, especially over the mid- and high-latitude oceans. However, precipitation is similar to white noise across much of the globe. When Earth system model variance is compared to variance generated by simple autocorrelation, it is found that tropical temperature variability in Earth system models is difficult to distinguish from variability generated by simple autocorrelation. By contrast, both forced and unforced Earth system models produce variability distinct from a simple autoregressive process over most high-latitude oceans. This new analysis of tropical paleoclimate records suggests that low-frequency variance dominates the temperature spectrum across the tropical Pacific and Indian Oceans, but in many Earth system models, interannual variance dominates the simulated central and eastern tropical Pacific temperature spectrum, regardless of forcing. Tropical Pacific model spectra are compared to spectra from the instrumental record, but the short instrumental record likely cannot provide accurate multidecadal–centennial-scale variance estimates. In the coming decades, both forced and natural patterns of decade–century-scale variability will determine climate-related risks. Underestimating low-frequency temperature and precipitation variability may significantly alter our understanding of the projections of these climate impacts.
Optimization of Sea Surface Current Retrieval Using a Maximum Cross-Correlation Technique on Modeled Sea Surface Temperature
Authors: Heuzé Céline , Carvajal Gisela K. , Eriksson Leif E. B. 
Published: August 2017

AbstractUsing sea surface temperature from satellite images to retrieve sea surface currents is not a new idea, but so far its operational near-real-time implementation has not been possible. Validation studies are too region specific or uncertain, sometimes because of the satellite images themselves. Moreover, the sensitivity of the most common retrieval method, the maximum cross correlation, to the parameters that have to be set is unknown. Using model outputs instead of satellite images, biases induced by this method are assessed here, for four different seas of western Europe, and the best of nine settings and eight temporal resolutions are determined. The regions with strong currents return the most accurate results when tracking a 20-km pattern between two images separated by 6–9 h. The regions with weak currents favor a smaller pattern and a shorter time interval, although their main problem is not inaccurate results but missing results: where the velocity is too low to be picked by the retrieval. The results are not impaired by the restrictions imposed by ocean surface current dynamics and available satellite technology, indicating that automated sea surface current retrieval from sea surface temperature images is feasible, for pollution confinement, search and rescue, and even for more energy-efficient and comfortable ship navigation.
Conjunctival Flora of Human Immunodeficiency Virus Patients on Antiretroviral Treatment
Authors: Giles Kagmeni , Bilong Yannick , Dohvoma Andin Viola , Ebana Steve Robert , Gonsu Hortance 
Published: August 2017

Objectives: To determine the conjunctival flora of human immunodeficiency virus (HIV) patients on antiretroviral treatment (ART). Methodology: A total of 104 conjunctival swabs from 104 HIV patients on ART underwent microbiological evaluation to describe the flora. Result: There were 71 (68.26%) women and 33 (31.74%) men. The mean age was 42.9 ± 9.77 (range: 22-70) years. Negative cultures were found in 39 (37.50%) cases. Bacterial growth occurred in 65 (62.50%) cases. Coagulase-negative Staphylococcus was found in 59 eyes (90.76%), and coagulase-positive in 3 eyes (4.61%). There was a significant correlation between the duration of ART, the degrees of immunosuppression, and bacterial growth. Conclusions: Knowledge of the conjunctival flora in HIV patients may provide a better guideline in the choice of antibiotic for the management of ocular surface infections.
A Systematic Literature Review and Research Agenda for Organ Donation Decision Communication
Authors: Knox Kathy , Parkinson Joy , Pang Bo , Fujihira Haruka , David Patricia , Rundle-Thiele Sharyn 
Published: August 2017

Background: This study systematically located and appraised peer-reviewed evidence for the efficacy of strategies to increase organ donation decision communication among adults including an assessment of study quality to guide future research in this field. There is little room to move in strengthening unanimously positive public attitudes toward organ donation. Consequently, researchers have called for a focus on organ donation decision communication to understand modifiable factors to increase organ donation rates. Methods: Multiple databases were searched during September 2015, and 44 studies were selected for inclusion. Data concerning participants, design, and outcomes were extracted. Studies were rated for quality and levels of evidence. Findings: Although not amenable to meta-analysis, the literature indicates that approximately 50% of adults who are willing to become an organ donor have discussed this decision with family. The majority of research was conducted in a Western context with an overrepresentation of students. Strategies to increase communication include education, motivation, input from lived experience, efforts to address salient audience beliefs, and scheduled reminders or prompts. Intentions and willingness to discuss organ donation were consistently positively related to discussion behavior; however, formative research and experimental studies testing theoretically driven interventions were scarce. Conclusions: There is mixed evidence for the role of demographic and attitudinal characteristics in the success of organ donation communication interventions. Additional theoretically based research is recommended to establish boundary conditions and validate strategies to increase organ donation decision communication among adults.
Patient-reported outcomes of carpal tunnel release surgery in patients with bilateral severe carpal tunnel syndrome
Authors: Tang C. Q. Y. , Lai S. W. H. , Tay S. C. 
Published: August 2017

This retrospective study examined whether the presenting complaint of numbness is relieved post-operatively in severe carpal tunnel syndrome and also assessed any correlation between outcomes of the first and second procedures in staged bilateral carpal tunnel releases. Carpal tunnel release (60 open and 38 endoscopic) was done in 49 patients with bilateral severe carpal tunnel syndrome. There was complete resolution of numbness post-operatively in 77% ( n = 75) of hands. The median post-operative time before complete resolution of numbness was 21 days (IQR 8 to 21; range 3 to 482). The likelihood of complete resolution of symptoms after the second carpal tunnel release in patients with complete resolution of symptoms after the first carpal tunnel release was 22 (95% CI: 4 to 131) times that of the likelihood of improvement in patients with incomplete resolution of symptoms after the first carpal tunnel release. Level of evidence: IV
Complementary and alternative treatment in functional dyspepsia
Authors: Chiarioni Giuseppe , Pesce Marcella , Fantin Alberto , Sarnelli Giovanni 
Published: August 2017

Introduction and aim The popularity of complementary and alternative medicine (CAM) in treating functional gastrointestinal disorders (FGIDs) has steadily increased in Western countries. We aimed at analyzing available data on CAM effectiveness in functional dyspepsia (FD) patients. Methods A bibliographical search was performed in PubMed using the following keywords: “complementary/alternative medicine,” “hypnosis,” “acupuncture” and/or “functional dyspepsia.” Results In community settings, almost 50% of patients with FGIDs used CAM therapies. Herbal remedies consist of multi-component preparations, whose mechanisms of action have not been systematically clarified. Few studies analyzed the effectiveness of acupuncture in Western countries, yielding conflicting results and possibly reflecting a population bias of this treatment. Hypnosis has been extensively used in irritable bowel syndrome, but few data support its role in treating FD. Conclusions Although some supporting well-designed studies have been recently performed, additional randomized, controlled trials are needed before stating any recommendation on CAM effectiveness in treating FD.
A national opinion study supports tobacco cessation by oral health professionals in Japan
Authors: Nagao Toru , Fukuta Jinichi , Seto Kanichi , Saigo Keietsu , Hanioka Takashi , Kurita Kenichi , Tonai Iwai , Yamashiro Masashi , Kusama Mikio , Satomura Kazuto , Izumi Yuichi , Mizutani Koji , Aoyama Norio , Tsumanuma Yuka , Imai Yutaka , Ishigaki Yoshiki , Nikaido Masahiko , Yoshino Hiroyuki , Sugai Toshiro , Kawana Hiromasa , Hamada Suguru , Matsuo Akira , Miura Kazue 
Published: August 2017

Background: Oral health professionals (OHPs) could have an important role in contributing to tobacco-dependence treatment of patients who visit dental clinics. How the public may perceive the role of OHPs in this capacity, however, has not been formally evaluated. The objective of this study was to assess national awareness and receptivity among Japanese in terms of the implementation of tobacco cessation counseling and treatment (TCCT) by OHPs in dental settings covered by National Health Insurance (NHI). The study participants’ awareness and knowledge on tobacco-related health disparities were also examined. Method: A questionnaire survey was used to assess the opinions among patients who visited hospital dental and oral and maxillofacial departments and private dental clinics ( n = 27) spread across several prefectures in Japan on their acceptance if tobacco cessation services were given by dentists and dental hygienists. Result: Overall, 963 survey sheets were eligible for the analysis. To the inquiry on tobacco-related oral diseases (TRODs), majority were aware of tooth staining (85%) and bad breathe (80%). However, less than half of respondents were aware of oral cancer (47%) and only 32% of oral precancer. OHPs were acceptable to the majority of respondents for TCCT: ≥70 age-group (84%), ex-smokers (84%) or never smokers (81%), never drinkers (83%), and students (86%). Paradoxically, current smokers (60%) were less likely to accept OHP for TCCT. However, those willing to quit within a month (89%) were willing to accept any help from OHP than those with no decision to quit (58%) ( p = 0.029). Conclusion: The result of this nationwide survey in Japan supported an expansion of duties of OHPs to provide TCCT to dental patients covered by NHI. Japanese patients who were willing to quit smoking were likely to accept TCCT in a dental setting, supporting the scheme for the introduction of tobacco control in dentistry.
Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response
Authors: Thumbigere Math V. , Rebouças P. , Giovani P.A. , Puppin-Rontani R.M. , Casarin R. , Martins L. , Wang L. , Krzewski K. , Introne W.J. , Somerman M.J. , Nociti F.H. , Kantovitz K.R. 
Published: August 2017

Chédiak-Higashi syndrome (CHS), a rare autosomal recessive disorder caused by mutations in the lysosomal trafficking regulator gene (LYST), is associated with aggressive periodontitis. It is suggested that LYST mutations affect the toll-like receptor (TLR)–mediated immunoinflammatory response, leading to frequent infections. This study sought to determine the periodontal status of patients with classic (severe) and atypical (milder) forms of CHS and the immunoregulatory functions of gingival fibroblasts in CHS patients. In contrast to aged-matched healthy controls, atypical (n = 4) and classic (n = 3) CHS patients presented with mild chronic periodontitis with no evidence of gingival ulceration, severe tooth mobility, or premature exfoliation of teeth. As a standard of care, all classic CHS patients had undergone bone marrow transplantation (BMT). Primary gingival fibroblasts obtained from atypical and BMT classic CHS patients displayed higher protein expression of TLR-2 (1.81-fold and 1.56-fold, respectively) and decreased expression of TLR-4 (−2.5-fold and −3.85-fold, respectively) at baseline when compared with healthy control gingival fibroblasts. When challenged with whole bacterial extract of Fusobacterium nucleatum, both atypical and classic CHS gingival fibroblasts failed to up-regulate TLR-2 and TLR-4 expression when compared with their respective untreated groups and control cells. Cytokine multiplex analysis following F. nucleatum challenge showed that atypical CHS gingival fibroblasts featured significantly increased cytokine expression (interleukin [IL]–2, IL-4, IL-5, IL-6, IL-10, IL-12, interferon-γ, tumor necrosis factor–α), whereas classic CHS cells featured similar/decreased cytokine expression when compared with treated control cells. Collectively, these results suggest that LYST mutations in CHS patients affect TLR-2 and TLR-4 expression/function, leading to dysregulated immunoinflammatory response, which in turn may influence the periodontal phenotype noted in CHS patients. Furthermore, our results suggest that atypical CHS patients and classic CHS patients who undergo BMT early in life are less susceptible to aggressive periodontitis and that hematopoietic cells play a critical role in mitigating the risk of aggressive periodontitis in CHS. Knowledge Transfer Statement: Results from this study can be used to create awareness among clinicians and researchers that not all CHS patients exhibit historically reported aggressive periodontitis, especially if they have atypical CHS disease or have received bone marrow transplantation. LYST mutations in CHS patients may affect TLR-2 and TLR-4 expression/function leading to dysregulated immunoinflammatory response, which in turn may influence the periodontal phenotype noted in CHS patients.
Pathophysiology of thrombotic thrombocytopenic purpura
Authors: Sadler J. Evan 
Published: August 2017

AbstractThe discovery of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) revolutionized our approach to thrombotic thrombocytopenic purpura (TTP). Inherited or acquired ADAMTS13 deficiency allows the unrestrained growth of microthrombi that are composed of von Willebrand factor and platelets, which account for the thrombocytopenia, hemolytic anemia, schistocytes, and tissue injury that characterize TTP. Most patients with acquired TTP respond to a combination of plasma exchange and rituximab, but some die or acquire irreversible neurological deficits before they can respond, and relapses can occur unpredictably. However, knowledge of the pathophysiology of TTP has inspired new ways to prevent early deaths by targeting autoantibody production, replenishing ADAMTS13, and blocking microvascular thrombosis despite persistent ADAMTS13 deficiency. In addition, monitoring ADAMTS13 has the potential to identify patients who are at risk of relapse in time for preventive therapy.
Clinical profile, biological markers, and comorbidity index as predictors of transplant-related mortality after allo-HSCT
Authors: Xhaard Aliénor , Cunha Renato , Busson Marc , Robin Marie , Dhedin Nathalie , Coman Tereza , Cabannes-Hamy Aurélie , Sicre de Fontbrune Flore , Michonneau David , Socié Gérard , Calado Rodrigo T. , Peffault de Latour Régis 
Published: August 2017

Key Points
Pre–allo-HSCT age-adjusted recipient telomere length and mismatched unrelated donor predict TRM.
The role of heterogeneity in asthma: a structure‐to‐function perspective
Authors: Lui Justin K. , Lutchen Kenneth R. 
Published: August 2017

AbstractA number of methods have evolved through the years in probing the dysfunction that impacts mechanics and ventilation in asthma. What has been consistently found is the notion of heterogeneity that is not only captured in the frequency dependence of lung mechanics measurements but also rendered on imaging as patchy diffuse areas of ventilation defects. The degree of heterogeneity has been linked to airway hyperresponsiveness, a hallmark feature of asthma. How these heterogeneous constriction patterns lead to functional impairment in asthma have only been recently explored using computational airway tree models. By synthesizing measurements of lung mechanics and advances in imaging, computational airway tree models serve as a powerful engine to accelerate our understanding of the physiologic changes that occur in asthma. This review will be focused on the current state of investigational work on the role of heterogeneity in asthma, specifically exploring the structural and functional relationships.
Milton Much Revolving
Authors: Greenberg Marissa 
Published: August 2017

Abstract
Revolution as an act of turning is a crucial yet overlooked feature of Milton’s conception of historical periods. This essay, by examining Milton’s imagery of revolution, seeks to challenge conventional associations of Milton and periodization with teleological culmination and inaugural disruption. In Paradise Lost and Paradise Regained the phrase much revolving becomes iconic of revolution as period-defining movement. Milton’s characters pivot, roll, twist, contort, resist, and return. In doing so, they show, and not simply describe, the lived experience of periodizing change. The poet dismisses understandings of historical periods as closed cycles or linear progressions that are defined by renowned individuals and monumental events. Milton reveals periods to be open-ended and helical and makes immediately sensible the quotidian events, no less apocalyptic for their familiarity, that generate history.
The Age of Shakespeare versus the Age of Milton: Reopening the Noisy Theaters
Authors: Staines John D. 
Published: August 2017

AbstractThis essay explores the political implications of the periodization divides created by the closing of the public theaters in 1642 at the start of the English Civil War and their reopening in 1660 at the restoration of Charles II. The meaning of the theater, and the meanings attributed to the cultural icons of Shakespeare and Milton, played important parts in the cultural battle between royalists and republicans, and those debates continue to shape literary studies in the twenty-first-century university despite recent reevaluations of the literature of the Civil War and the Revolution. Shakespeare is walled off from Milton, drama separated from poetry, prose, and epic. These divides distort the readings of the period’s literature and, at a time of resource scarcity, threaten to limit which writers and texts are researched and taught. The essay concludes with a reading of Paradise Lost that puts drama, dialogue, and conversation at the center. In the dramatic Milton, meaning is found in dialogue and conversation, growing out of the noise of debate and conflict.
Giving eyespots a shiner: Pharmacologic manipulation of the Io moth wing pattern
Authors: Sourakov Andrei 
Published: August 2017

Our knowledge of wing pattern formation in Lepidoptera has advanced significantly in recent years due to the careful examination of several groups of butterflies. The eyespot is a prominent feature of Lepidoptera wing pattern, especially in the family Saturniidae. The present study examined how sulfated polysaccharides, which are known to simulate cold shock effect in nymphalid butterflies, affected the wing pattern formation of the Io moth, Automeris io (Saturniidae). Prepupae and pupae of this species were subjected to injections of heparin and cold shock. While the cold shock had little to no effect on wing pattern, the aberrations resulting from heparin injections consisted of moderate to profound increases in melanism around the eyespots. The resulting aberrations are dubbed ‘Black Eye’ and ‘Comet Eye.’ Most other known aberrations of Automeris io eyespots are summarized, illustrated and named.