bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioimpedimetric analysis in conjunction with growth dynamics to differentiate aggressiveness of cancer cells
Authors: Parekh Aditya , Das Debanjan , Das Subhayan , Dhara Santanu , Biswas Karabi , Mandal Mahitosh , Das Soumen 
Published: January 2018

AbstractDetermination of cancer aggressiveness is mainly assessed in tissues by looking at the grade of cancer. There is a lack of specific method to determine aggressiveness of cancer cells in vitro. In our present work, we have proposed a bio-impedance based non-invasive method to differentiate aggressive property of two breast cancer cell lines. Real-time impedance analysis of MCF-7 (less aggressive) and MDA-MB-231 cells (more aggressive) demonstrated unique growth pattern. Detailed slope-analysis of impedance curves at different growth phases showed that MDA-MB-231 had higher proliferation rate and intrinsic resistance to cell death, when allowed to grow in nutrient and space limiting conditions. This intrinsic nature of death resistance of MDA-MB-231 was due to modulation and elongation of filopodia, which was also observed during scanning electron microscopy. Results were also similar when validated by cell cycle analysis. Additionally, wavelet based analysis was used to demonstrate that MCF-7 had lesser micromotion based cellular activity, when compared with MDA-MB-231. Combined together, we hypothesize that analysis of growth rate, death resistance and cellular energy, through bioimpedance based analysis can be used to determine and compare aggressiveness of multiple cancer cell lines. This further opens avenues for extrapolation of present work to human tumor tissue samples.
Interfacial Coupling Effect on Electron Transport in MoS2/SrTiO3 Heterostructure: An Ab-initio Study
Authors: Bano Amreen , Gaur N. K. 
Published: January 2018

AbstractA variety of theoretical and experimental works have reported several potential applications of MoS2 monolayer based heterostructures (HSs) such as light emitting diodes, photodetectors and field effect transistors etc. In the present work, we have theoretically performed as a model case study, MoS2 monolayer deposited over insulating SrTiO3 (001) to study the band alignment at TiO2 termination. The interfacial characteristics are found to be highly dependent on the interface termination. With an insulating oxide material, a significant band gap (0.85eV) is found in MoS2/TiO2 interface heterostructure (HS). A unique electronic band profile with an indirect band gap (0.67eV) is observed in MoS2 monolayer when confined in a cubic environment of SrTiO3 (STO). Adsorption analysis showed the chemisorption of MoS2 on the surface of STO substrate with TiO2 termination which is justified by the charge density calculations that shows the existence of covalent bonding at the interface. The fabrication of HS of such materials paves the path for developing the unprecedented 2D materials with exciting properties such as semiconducting devices, thermoelectric and optoelectronic applications.
Recurrence patterns after maximal surgical resection and postoperative radiotherapy in anaplastic gliomas according to the new 2016 WHO classification
Authors: Im Jung Ho , Hong Je Beom , Kim Se Hoon , Choi Junjeong , Chang Jong Hee , Cho Jaeho , Suh Chang-Ok 
Published: January 2018

AbstractWe assessed the appropriateness of current radiotherapy volume for WHO grade III gliomas. The records of 73 patients with WHO grade III gliomas who received postoperative radiotherapy between 2001 and 2013 were retrospectively reviewed. Based on the 2016 WHO classification, 25/73 (34.2%) patients had anaplastic oligodendroglioma (AO), IDH-mutant and 1p/19q-codeleted; 11/73 (15.1%) patients had anaplastic astrocytoma, IDH-mutant; and 37/73 (50.7%) patients had anaplastic astrocytoma, IDH-wildtype. The extent of resection (EOR) was total in 43 patients (58.9%). The median follow-up time was 84 months. The 5-year overall survival was 65.4%. Of 31 patients with documented recurrences, 20 (64.5%) had infield gross tumor volume (GTV) failure, six (19.4%) had clinical target volume (CTV)/marginal failure, and five (16.1%) had outfield failure/seeding. In 13 recurrences among 43 patients who underwent gross total resection (GTR), six (46.2%) had infield CTV/marginal failure. However, among 30 patients for whom GTR was not conducted, infield GTV failure was dominant (77.8%). Seventeen patients with AO, IDH-mutant and 1p/19q-codeleted who underwent GTR experienced no recurrence. In conclusion, maximal surgical resection and postoperative radiotherapy resulted in a favorable prognosis, especially in patients with GTR, IDH mutation, and 1p/19q codeletion. Patterns of failure differed by EOR.
The space charge limited current and huge linear magnetoresistance in silicon
Authors: Liu Y. , Wang H. , Jin X. , Zhang M. 
Published: January 2018

AbstractHuge magnetoresistance in space charge regime attracts broad interest on non-equilibrium carrier transport under high electric field. However, the accurate fitting for the current-voltage curves from Ohmic to space charge regime under magnetic fields has not been achieved quantitatively. We conjecture that the localized intensive charge dynamic should be taken into consideration. Here, by introducing a field-dependent dielectric constant, for the first time, we successfully simulate the current-voltage curves of covalent crystal silicon wafers under different magnetic fields (0–1 Tesla). The simulation reveals that the optical phonon, instead of the acoustic phonon, plays a major role for the carriers transport under magnetic fields in space charge regime.
An evaluation of the effect of pulse-shape on grey and white matter stimulation in the rat brain
Authors: Deprez Marjolijn , Luyck Kelly , Luyten Laura , Tambuyzer Tim , Nuttin Bart , Mc Laughlin Myles 
Published: January 2018

AbstractDespite the current success of neuromodulation, standard biphasic, rectangular pulse shapes may not be optimal to achieve symptom alleviation. Here, we compared stimulation efficiency (in terms of charge) between complex and standard pulses in two areas of the rat brain. In motor cortex, Gaussian and interphase gap stimulation (IPG) increased stimulation efficiency in terms of charge per phase compared with a standard pulse. Moreover, IPG stimulation of the deep mesencephalic reticular formation in freely moving rats was more efficient compared to a standard pulse. We therefore conclude that complex pulses are superior to standard stimulation, as less charge is required to achieve the same behavioral effects in a motor paradigm. These results have important implications for the understanding of electrical stimulation of the nervous system and open new perspectives for the design of the next generation of safe and efficient neural implants.
Evidence of a cubic iron sub-lattice in t-CuFe2O4 demonstrated by X-ray Absorption Fine Structure
Authors: Caddeo Francesco , Loche Danilo , Casula Maria F. , Corrias Anna 
Published: January 2018

AbstractCopper ferrite, belonging to the wide and technologically relevant class of spinel ferrites, was grown in the form of t-CuFe2O4 nanocrystals within a porous matrix of silica in the form of either an aerogel or a xerogel, and compared to a bulk sample. Extended X-ray absorption fine structure (EXAFS) spectroscopy revealed the presence of two different sub-lattices within the crystal structure of t-CuFe2O4, one tetragonal and one cubic, defined by the Cu2+ and Fe3+ ions respectively. Our investigation provides evidence that the Jahn-Teller distortion, which occurs on the Cu2+ ions located in octahedral sites, does not affect the coordination geometry of the Fe3+ ions, regardless of their location in octahedral or tetrahedral sites.
Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation
Authors: Basic Marijana , Buettner Manuela , Keubler Lydia M. , Smoczek Anna , Bruesch Inga , Buchheister Stephanie , Bleich André 
Published: January 2018

AbstractThe TLR4 co-receptor CD14 was identified as an IBD candidate gene. Here, its influence on the intestinal barrier was addressed utilizingE. coliNissle (EcN), which induces severe inflammation in germfree TLR4−/−mice. After monoassociation, EcN was detected in spleens and livers of TLR4−/−and CD14−/−but not wildtype mice. Barrier impairment was characterized by increased apoptosis and decreased epithelial junction (EJ) expression and was reversed by TLR2 stimulation in CD14−/−mice. Bone marrow (BM) transplantation revealed contribution of hematopoietic and non-hematopoietic cells towards intestinal homeostasis. EcN inoculated WT mice showed B cell activation, CD14−/−and TLR4−/−mice cytotoxic T cell and impaired B cell responses. The latter was characterized by absence of B cells in TLR4−/−mice, decreased levels of EcN induced immunoglobulins and downregulation of their transporter pIgR. EcN colonization of mice with genetically or antibody induced impaired B cell response resulted in dissemination of EcN and downregulation of EJ. BM chimeras indicated that CD14 originating from radiation resistant cells is sufficient to restore EJ-function. Overall, CD14/TLR4 signalling seems to be critical for intestinal barrier function and for the crosstalk between B cells and the epithelium, underlining that CD14 serves as a protective modulator of intestinal homeostasis.
Engineered nonlinear materials using gold nanoantenna array
Authors: Drachev Vladimir P. , Kildishev Alexander V. , Borneman Joshua D. , Chen Kuo-Ping , Shalaev Vladimir M. , Yamnitskiy Konstantin , Norwood Robert A. , Peyghambarian Nasser , Marder Seth R. , Padilha Lazaro A. , Webster Scott , Ensley Trenton R. , Hagan David J. , Van Stryland Eric W. 
Published: January 2018

AbstractGold dipole nanoantennas embedded in an organic molecular film provide strong local electromagnetic fields to enhance both the nonlinear refractive index (n2) and two-photon absorption (2PA) of the molecules. An enhancement of 53× for 2PA and 140× for nonlinear refraction is observed for BDPAS (4,4′-bis(diphenylamino)stilbene) at 600 nm with only 3.7% of gold volume fraction. The complex value of the third-order susceptibility enhancement results in a sign change of n2 for the effective composite material relative to the pure BDPAS film. This complex nature of the enhancement and the tunability of the nanoantenna resonance allow for engineering the effective nonlinear response of the composite film.
Widespread bone-based fluorescence in chameleons
Authors: Prötzel David , Heß Martin , Scherz Mark D. , Schwager Martina , Padje Anouk van’t , Glaw Frank 
Published: January 2018

AbstractFluorescence is widespread in marine organisms but uncommon in terrestrial tetrapods. We here show that many chameleon species have bony tubercles protruding from the skull that are visible through their scales, and fluoresce under UV light. Tubercles arising from bones of the skull displace all dermal layers other than a thin, transparent layer of epidermis, creating a ‘window’ onto the bone. In the genusCalumma, the number of these tubercles is sexually dimorphic in most species, suggesting a signalling role, and also strongly reflects species groups, indicating systematic value of these features. Co-option of the known fluorescent properties of bone has never before been shown, yet it is widespread in the chameleons of Madagascar and some African chameleon genera, particularly in those genera living in forested, humid habitats known to have a higher relative component of ambient UV light. The fluorescence emits with a maximum at around 430 nm in blue colour which contrasts well to the green and brown background reflectance of forest habitats. This discovery opens new avenues in the study of signalling among chameleons and sexual selection factors driving ornamentation.
A multi-omics study of the grapevine-downy mildew (Plasmopara viticola) pathosystem unveils a complex protein coding- and noncoding-based arms race during infection
Authors: Brilli Matteo , Asquini Elisa , Moser Mirko , Bianchedi Pier Luigi , Perazzolli Michele , Si-Ammour Azeddine 
Published: January 2018

AbstractFungicides are applied intensively to prevent downy mildew infections of grapevines (Vitis vinifera) with high impact on the environment. In order to develop alternative strategies we sequenced the genome of the oomycete pathogen Plasmopara viticola causing this disease. We show that it derives from a Phytophthora-like ancestor that switched to obligate biotrophy by losing genes involved in nitrogen metabolism and γ-Aminobutyric acid catabolism. By combining multiple omics approaches we characterized the pathosystem and identified a RxLR effector that trigger an immune response in the wild species V. riparia. This effector is an ideal marker to screen novel grape resistant varieties. Our study reveals an unprecedented bidirectional noncoding RNA-based mechanism that, in one direction might be fundamental for P. viticola to proficiently infect its host, and in the other might reduce the effects of the infection on the plant.
TiO2 Nanoribbons/Carbon Nanotubes Composite with Enhanced Photocatalytic Activity; Fabrication, Characterization, and Application
Authors: Shaban Mohamed , Ashraf Abdallah M. , Abukhadra Mostafa R. 
Published: January 2018

AbstractTiO2 nanoribbons (TiO2 NRs) loaded with FeCo-Al2O3 catalyst were synthesized and used as a precursor in the synthesis of TiO2 nanoribbons/carbon nanotubes (TiO2 NRs/CNTs) composite by a chemical vapor deposition (CVD) method. TiO2 NRs and TiO2 NRs/CNTs composite were characterized by XRD, FT-IR, TEM, SEM, EDX and UV-Vis spectrophotometer. The results revealed the formation of TiO2-B and hydrogen titanate nanoribbon like structures by the hydrothermal treatment. After loading TiO2 NRs by FeCo-Al2O3 catalyst and the CVD growth of carbon nanotubes, the synthetic TiO2 nanoribbons converted entirely to TiO2-B nanoribbons with nanopits structure. The composite composed of tube-like nanostructures forming an interlocked network from CNTs and TiO2-B NRs. The composite shows a relatively red-shifted band gap (3.09 eV), broader and stronger UV absorption band relative to TiO2 NRs. The photocatalytic properties of TiO2 NRs and TiO2 NRs/CNTs composite were studied under sunlight irradiation. The photocatalytic degradation of methylene blue (MB) dye was investigated as a function of contact time, dye concentration, and catalyst dose. The kinetics and mechanisms of degradation were discussed. TiO2 NRs/CNTs composite showed higher stability after six runs and 50% shorter irradiation time than TiO2 NRs photocatalyst.
Decoding Musical Training from Dynamic Processing of Musical Features in the Brain
Authors: Saari Pasi , Burunat Iballa , Brattico Elvira , Toiviainen Petri 
Published: January 2018

AbstractPattern recognition on neural activations from naturalistic music listening has been successful at predicting neural responses of listeners from musical features, and vice versa. Inter-subject differences in the decoding accuracies have arisen partly from musical training that has widely recognized structural and functional effects on the brain. We propose and evaluate a decoding approach aimed at predicting the musicianship class of an individual listener from dynamic neural processing of musical features. Whole brain functional magnetic resonance imaging (fMRI) data was acquired from musicians and nonmusicians during listening of three musical pieces from different genres. Six musical features, representing low-level (timbre) and high-level (rhythm and tonality) aspects of music perception, were computed from the acoustic signals, and classification into musicians and nonmusicians was performed on the musical feature and parcellated fMRI time series. Cross-validated classification accuracy reached 77% with nine regions, comprising frontal and temporal cortical regions, caudate nucleus, and cingulate gyrus. The processing of high-level musical features at right superior temporal gyrus was most influenced by listeners’ musical training. The study demonstrates the feasibility to decode musicianship from how individual brains listen to music, attaining accuracy comparable to current results from automated clinical diagnosis of neurological and psychological disorders.
Optimal ranges of variables for an effective adsorption of lead(II) by the agricultural waste pomelo (Citrus grandis) peels using Doehlert designs
Authors: Yu Xiao-Lan , He Yong 
Published: January 2018

AbstractThe capacity of pomelo peels’ adsorption on lead(II) from aqueous solutions without modifications was investigated and confirmed. Four variables in this study, pH, temperature, time and initial concentration of lead(II), significantly affected the adsorption rate of pomelo peels. The prediction model and optimal ranges of optimized variables were given by Doehlert designs, which made the selection of variables rapid, flexible and effortless to obtain an adsorption rate reaching 99.9% and 20 mg/L for initial lead(II) concentration, 3 for pH, 50 °C for temperature and 210 min for time was a choice. The higher correlation coefficient as well as the more consistent value of experimental equilibrium adsorption capacity of the pseudo-first-order model suggested it bore a better prediction of the adsorption kinetics than the pseudo-second-order model. Langmuir model indicated the adsorption mechanism of pomelo peels was monolayer sorption with the help of both physical adsorption and chemical bonding, which were demonstrated by scanning electron microscopy and Fourier transform-infrared, respectively. The ability of pomelo peels to adsorb lead(II) from aqueous solutions was not interfered with the presence of calcium(II), magnesium(II), copper(II) and zinc(II). Pomelo peels had the potential to be utilized in the simultaneous adsorption of toxic heavy metal ions.
Exercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice
Authors: Castellani Laura N. , Peppler Willem T. , Miotto Paula M. , Bush Natasha , Wright David C. 
Published: January 2018

AbstractOlanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6. To determine if IL-6 was involved in the mechanisms through which exhaustive exercise protected against olanzapine-induced hyperglycemia several additional experiments were completed. Treatment with IL-6 (3 ng/g bw, IP) alone did not protect against olanzapine-induced increases in blood glucose. The protective effects of exhaustive exercise against olanzapine-induced increases in blood glucose were intact in whole body IL-6 knockout mice. Similarly, treating mice with an IL-6 neutralizing antibody prior to exhaustive exercise did not negate the protective effect of exercise against olanzapine-induced hyperglycemia. Our findings provide evidence that a single bout of exhaustive exercise protects against acute olanzapine-induced hyperglycemia and that IL-6 is neither sufficient, nor required for exercise to protect against increases in blood glucose with olanzapine treatment.
Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase
Authors: Turegun Bengi , Baker Richard W. , Leschziner Andres E. , Dominguez Roberto 
Published: January 2018

AbstractThe catalytic subunits of SWI/SNF-family and INO80-family chromatin remodelers bind actin and actin-related proteins (Arps) through an N-terminal helicase/SANT-associated (HSA) domain. Between the HSA and ATPase domains lies a conserved post-HSA (pHSA) domain. The HSA domain of Sth1, the catalytic subunit of the yeast SWI/SNF-family remodeler RSC, recruits the Rtt102-Arp7/9 heterotrimer. Rtt102-Arp7/9 regulates RSC function, but the mechanism is unclear. We show that the pHSA domain interacts directly with another conserved region of the catalytic subunit, protrusion-1. Rtt102-Arp7/9 binding to the HSA domain weakens this interaction and promotes the formation of stable, monodisperse complexes with DNA and nucleosomes. A crystal structure of Rtt102-Arp7/9 shows that ATP binds to Arp7 but not Arp9. However, Arp7 does not hydrolyze ATP. Together, the results suggest that Rtt102 and ATP stabilize a conformation of Arp7/9 that potentiates binding to the HSA domain, which releases intramolecular interactions within Sth1 and controls DNA and nucleosome binding.
Propagating wave in active region-loops, located over the solar disk observed by the Interface Region Imaging Spectrograph
Authors: Zhang B. , Hou Y. J. , Zhang J. 
Published: January 2018

Aims. We aim to ascertain the physical parameters of a propagating wave over the solar disk detected by the Interface Region Imaging Spectrograph (IRIS).
Methods. Using imaging data from the IRIS and the Solar Dynamic Observatory (SDO), we tracked bright spots to determine the parameters of a propagating transverse wave in active region (AR) loops triggered by activation of a filament. Deriving the Doppler velocity of Si IV line from spectral observations of IRIS, we have determined the rotating directions of active region loops which are relevant to the wave.
Results. On 2015 December 19, a filament was located on the polarity inversion line of the NOAA AR 12470. The filament was activated and then caused a C1.1 two-ribbon flare. Between the flare ribbons, two rotation motions of a set of bright loops were observed to appear in turn with opposite directions. Following the end of the second rotation, a propagating wave and an associated transverse oscillation were detected in these bright loops. In 1400 Å channel, there was bright material flowing along the loops in a wave-like manner, with a period of ~128 s and a mean amplitude of ~880 km. For the transverse oscillation, we tracked a given loop and determine the transverse positions of the tracking loop in a limited longitudinal range. In both of 1400 Å and 171 Å channels, approximately four periods are distinguished during the transverse oscillation. The mean period of the oscillation is estimated as ~143 s and the displacement amplitude as between ~1370 km and ~690 km. We interpret these oscillations as a propagating kink wave and obtain its speed of ~1400 km s−1.
Conclusions. Our observations reveal that a flare associated with filament activation could trigger a kink propagating wave in active region loops over the solar disk.