bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in the understanding of trauma-induced coagulopathy
Authors: Chang Ronald , Cardenas Jessica C. , Wade Charles E. , Holcomb John B. 
Published: July 2016

AbstractTen percent of deaths worldwide are due to trauma, and it is the third most common cause of death in the United States. Despite a profound upregulation in procoagulant mechanisms, one-quarter of trauma patients present with laboratory-based evidence of trauma-induced coagulopathy (TIC), which is associated with poorer outcomes including increased mortality. The most common causes of death after trauma are hemorrhage and traumatic brain injury (TBI). The management of TIC has significant implications in both because many hemorrhagic deaths could be preventable, and TIC is associated with progression of intracranial injury after TBI. This review covers the most recent evidence and advances in our understanding of TIC, including the role of platelet dysfunction, endothelial activation, and fibrinolysis. Trauma induces a plethora of biochemical and physiologic changes, and despite numerous studies reporting differences in coagulation parameters between trauma patients and uninjured controls, it is unclear whether some of these differences may be “normal” after trauma. Comparisons between trauma patients with differing outcomes and use of animal studies have shed some light on this issue, but much of the data continue to be correlative with causative links lacking. In particular, there are little data linking the laboratory-based abnormalities with true clinically evident coagulopathic bleeding. For these reasons, TIC continues to be a significant diagnostic and therapeutic challenge.
Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner
Authors: McDonald-Hyman Cameron , Flynn Ryan , Panoskaltsis-Mortari Angela , Peterson Nicholas , MacDonald Kelli P. A. , Hill Geoffrey R. , Luznik Leo , Serody Jonathan S. , Murphy William J. , Maillard Ivan , Munn David H. , Turka Laurence A. , Koreth John , Cutler Corey S. , Soiffer Robert J. , Antin Joseph H. , Ritz Jerome , Blazar Bruce R. 
Published: July 2016

Key Points
IL-2/mAb complexes expand Tregs and treat established murine cGVHD, but concurrent T-effector cell expansion can reduce their therapeutic index. Prophylactic Treg infusions can prevent cGVHD, whereas therapeutic efficacy requires homing to and inhibition of the GC reaction.
Spillover from past recycling to green apparel shopping behavior: the role of environmental concern and anticipated guilt
Authors: Ha Sejin , Kwon SoYeon 
Published: July 2016

AbstractThis study explores catalytic behavior in the context of pro-environmental behaviors by examining the occurrence of spillover that performing recycling behavior promotes the likelihood to engage in green apparel purchases. Additionally, this study incorporates a potential mediator and a moderator, environmental concern and anticipated guilt, respectively, in order to explain the nature of the spillover process. The results of online survey data confirm the development of spillover in consumer behavior that past recycling behavior does spill over into green apparel/fashion product purchase behaviors through one’s motivational belief toward the environment, environmental concern. However, anticipated guilt, a motivation factor, does not moderate spillover among pro-environmental behaviors, at least between past recycling behavior and green apparel shopping behaviors. Theoretically, this study contributes to and extends the literature on spillover in pro-environmental behaviors by testing spillover across distinctive pro-environmental behaviors. This study also provides lessons for fashion retail marketers and government agencies in learning the importance of the social and ethical aspects of consumers’ green practices, beyond price/quality-based choices. Limitations and future research directions are discussed.
Altitude matters: differences in cardiovascular and respiratory responses to hypoxia in bar-headed geese reared at high and low altitudes
Authors: Lague Sabine L. , Chua Beverly , Farrell Anthony P. , Wang Yuxiang , Milsom William K. 
Published: July 2016

ABSTRACTBar-headed geese (Anser indicus) fly at high altitudes during their migration across the Himalayas and Tibetan plateau. However, we know relatively little about whether rearing at high altitude (i.e. phenotypic plasticity) facilitates this impressive feat because most of what is known about their physiology comes from studies performed at sea level. To provide this information, a comprehensive analysis of metabolic, cardiovascular and ventilatory responses to progressive decreases in the equivalent fractional composition of inspired oxygen (FiO2: 0.21, 0.12, 0.09, 0.07 and 0.05) was made on bar-headed geese reared at either high altitude (3200 m) or low altitude (0 m) and on barnacle geese (Branta leucopsis), a low-altitude migrating species, reared at low altitude (0 m). Bar-headed geese reared at high altitude exhibited lower metabolic rates and a modestly increased hypoxic ventilatory response compared with low-altitude-reared bar-headed geese. Although the in vivo oxygen equilibrium curves and blood-oxygen carrying capacity did not differ between the two bar-headed goose study groups, the blood-oxygen carrying capacity was higher than that of barnacle geese. Resting cardiac output also did not differ between groups and increased at least twofold during progressive hypoxia, initially as a result of increases in stroke volume. However, cardiac output increased at a higher FiO2 threshold in bar-headed geese raised at high altitude. Thus, bar-headed geese reared at high altitude exhibited a reduced oxygen demand at rest and a modest but significant increase in oxygen uptake and delivery during progressive hypoxia compared with bar-headed geese reared at low altitude.
The significance of respiration timing in the energetics estimates of free-ranging killer whales (Orcinus orca)
Authors: Roos Marjoleine M. H. , Wu Gi-Mick , Miller Patrick J. O. 
Published: July 2016

ABSTRACTRespiration rate has been used as an indicator of metabolic rate and associated cost of transport (COT) of free-ranging cetaceans, discounting potential respiration-by-respiration variation in O2 uptake. To investigate the influence of respiration timing on O2 uptake, we developed a dynamic model of O2 exchange and storage. Individual respiration events were revealed from kinematic data from 10 adult Norwegian herring-feeding killer whales (Orcinus orca) recorded with high-resolution tags (DTAGs). We compared fixed O2 uptake per respiration models with O2 uptake per respiration estimated through a simple ‘broken-stick’ O2-uptake function, in which O2 uptake was assumed to be the maximum possible O2 uptake when stores are depleted or maximum total body O2 store minus existing O2 store when stores are close to saturated. In contrast to findings assuming fixed O2 uptake per respiration, uptake from the broken-stick model yielded a high correlation (r2&gt;0.9) between O2 uptake and activity level. Moreover, we found that respiration intervals increased and became less variable at higher swimming speeds, possibly to increase O2 uptake efficiency per respiration. As found in previous studies, COT decreased monotonically versus speed using the fixed O2 uptake per respiration models. However, the broken-stick uptake model yielded a curvilinear COT curve with a clear minimum at typical swimming speeds of 1.7–2.4 m s−1. Our results showed that respiration-by-respiration variation in O2 uptake is expected to be significant. And though O2 consumption measurements of COT for free-ranging cetaceans remain impractical, accounting for the influence of respiration timing on O2 uptake will lead to more consistent predictions of field metabolic rates than using respiration rate alone.
Use of Mesoporous Silica Modified with Titanium Oxide as a Template for Preparation of Mesoporous Carbon Incorporating TiO2 Nanocrystals
Authors: Kitahara Masaki , Suzuki Kohei , Kubara Saori , Shimasaki Yuta , Shimojima Atsushi , Wada Hiroaki , Kuroda Kazuyuki 
Published: July 2016

Abstract
Mesoporous silica modified with titanium oxide is shown to be useful as a template for the preparation of mesoporous carbon incorporating TiO2 nanocrystals. The nanocomposite was prepared by deposition of carbon within the mesoporous silica template modified with titanium oxide, and subsequent template removal with NaOH (aq). The high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM) image of the prepared nanocomposite clearly showed that small TiO2 nanocrystals embedded on mesoporous carbon were formed. The Si–O–Ti bonds between mesoporous silica and titanium oxide layers are effective to suppress the migration of the Ti species, resulting in the formation of the TiO2 nanocrystals.
Providing Disciplines of Mathematical Cycle for Economics and Management with a Foreign Language Support
Authors: ��������  , Dubinina Galina 
Published: July 2016

The article presents arguments in favour of an interdisciplinary approach to training at a non-linguistic university, namely, the importance of English
language support for teaching mathematical disciplines. The authors consider the interaction between �Foreign languages� and �Mathematics� departments
in case analysis and preparing students for Case-Championships. The authors describe techniques of implementing a foreign language professionalization
through quasi-professional activity.
Technical Translation for Postgraduate Engineering Students As Foreign Language Course Component
Authors: ���������  , Sidorenko T. , ���������  , Gorbatova T. 
Published: July 2016

The article investigates the issues of the content of the foreign language training at technical universities. The authors analyze the goals and objectives as
well as the requirements and the content of the postgraduate language training to identify some discrepancy, which prevents the university community
from achieving the most effi cient outcomes in the training future researchers and engineers in terms of foreign language profi ciency. Based on the examples
provided, the authors highlight the necessity to revise the curriculum in order to change its focus and the major components as well as to review the
requirements for students at every stage of language learning. The authors do not propose the ready scenario and structure of the course, considering
it as the exceptional privilege of each university. However, the model that they propose in the paper and the conclusions they make, might be taken by
others as the ground for the course content design.
Lean Service Implementation Success Factors
Authors: Lisiecka Krystyna , Burka Iwona 
Published: July 2016

<p><strong>Purpose:</strong> The aim of this study was to assess the validity of the factors which have influence on the Lean Service (LS) principles implementation process that serves to improve the organization and economics of district heating companies operating on the Polish market. <br />Methodology: Diagnostic survey carried out in the selected trade industries.<br /><strong>Findings</strong>: Assessing the significance of the effective LS principles implementation factors, which serves to improve the functioning of district heating companies, has revealed the most important factor, which is – according to the respondents – a focus on minimizing waste in processes. Several waste groups were identified and distinguished. They are for example: waste resulting from the employees passive behaviors, unused creativity of employees, unnecessary motion. Answering the question asked in the title of the paper – according to the research - you can ascertain that the effective LS conception principles implementation success factors are, in particular: the involvement of management in process improvement, staff attitude to minimize waste in processes. The research resulted in the formulation of conclusions, one of which says that an effective remedy for the organization members passive behaviors can be Lean Behaviours. <br /><strong>Originality:</strong> This is a first unique study on the topic of the Lean Service implementation success factors in the heat engineering. The achieved results can be useful for district heating companies as a guidance to improve management systems in those organizations.</p><p> </p>
Sexualización en la publicidad digital de marcas de moda infantil: iniciativas ciudadanas y mecanismos de denuncia
Authors: Diaz-Bustamante Ventisca Mónica , Llovet Rodríguez Carmen , Patiño Alves Beatriz 
Published: July 2016

Los niños son presentados como objetos sexuales en gran parte, según el debate social, debido a la actividad de las marcas y medios vinculados a la moda. La metodología llevada a cabo combina un análisis de contenido de los catálogos de publicidad de moda infantil en Internet en el contexto español, con el objetivo de ver si las marcas de moda infantil sexualizan a los niños; una revisión de las iniciativas de denuncia en Internet para conocer si la sociedad civil está concienciada; y una revisión de la normativa jurídica y ética en la publicidad digital para verificar si hay una especial protección a los niños. Los hallazgos apuntan que casi la mitad de los niños de los catálogos (el 45.8%) muestran atributos que los sexualizan, que las niñas son las más perjudicadas -un 48.9% frente al 38.2% de los niños- y las marcas de moda infantil que sexualizan más son las de alta gama originalmente de adultos. Entre las conclusiones sobre la presencia de esta sexualización en los niños destaca la libertad creativa y el beneficio económico de las marcas. Respecto a las iniciativas, se concentran en este orden entre padres, Gobierno y asociaciones de consumidores. Se recomienda información a los ciudadanos para transformar sus quejas en procesos que inicien los mecanismos de protección legal y ética previstos para proteger a los niños.
A Ludicidade como Importante Estratégia de Ensino no PNAIC – Pacto Nacional pela Alfabetização na Idade Certa, em Juazeiro-BA.
Authors: Santos Geisa Gabrielle , Caffé Lívia Suilan Rosa , Caffé Filho Hesler Piedade 
Published: July 2016

Esse trabalho visa estabelecer um diálogo acadêmico entre a gestão estratégica, gestão de políticas públicas e elementos do PNAIC – Pacto Nacional pela Alfabetização na Idade Certa. O objetivo dessa produção é verificar a possibilidade da utilização da ludicidade na alfabetização em uma escola pública municipal, realizando uma revisão bibliográfica sobre estratégias contidas no Plano Nacional da Educação, entendendo como esses elementos se interagem sob a luz das políticas públicas e realizando uma experiência em uma escola da Rede municipal de ensino, na cidade de Juazeiro-BA. Para isso, buscou-se um referencial teórico que versasse nas linhas da gestão estratégica, gestão de políticas públicas, alfabetização e ludicidade. O método da pesquisa foi bibliográfico e estudo de caso. Verificou-se, no campo da pesquisa, que a ludicidade é fundamental para a condição de motivação na aprendizagem, que os jogos tem um grande papel no processo da alfabetização sem esquecer da importância de planejar atividades que atendam a todos os alunos, cada um dentro da sua necessidade pessoal e específica. Os autores sugerem ao final do estudo, que além de outros anos e modalidades de ensino da mesma instituição educacional, outras escolas e ambientes educacionais possam fazer uso e/ou potencializar essa importante estratégia de ensino. Palavras chaves: PNAIC, Ludicidade, Gestão Estratégica.
Gestão de Reclamações: Um Estudo de Caso no Instituto Nacional de Seguro Social
Authors: Siqueira Mary Roseane Bezerra , Santos Joelma Martins dos , Souza Neto Arcanjo Ferreira de 
Published: July 2016

O objetivo deste artigo é verificar como o Instituto Nacional do Seguro Social - INSS gerencia as informações da Gestão de reclamações, no município de Petrolina-PE.Foram feitas buscas com o objetivo de investigar se o órgão (nesse caso o INSS) possui técnicas específicas na sua gestão de reclamações, pois quando se trata de um ente púbico, em especial INSS, esse processo é reconhecido pela necessidade de uma relação coerente e eficiente com a sociedade, com a finalidade de proporcionar o compromisso do serviço prestado ao usuário. Para esse fim foi realizada a pesquisa bibliográfica juntamente com a pesquisa de campo, utilizando a ferramenta “entrevista”, com os gestores do INSS. E o resultado comprovado foi de que não havia uma habilitada gestão de reclamações inerente ao estudo do caso. Gestão de Reclamações, clientes administração pública.
Motivação no Serviço Público Resulta em Eficiência
Authors: Alves Ednayara Souza , Freire Géssica De Barros , Quevedo Andressa Pacífico Franco 
Published: July 2016

A motivação dos funcionários é imprescindível para o bom desempenho dos profissionais e o alcance dos objetivos organizacionais. Então, busca-se conhecer os fatores determinantes para motivá-los. Para isso, as teorias motivacionais elencam as necessidades dos indivíduos, bem como as suas peculiaridades que direcionam os seus comportamentos. Assim, o objetivo deste estudo é entender os fatores que motivam os servidores e sua relevância para a eficiência da Administração Pública. Este estudo utilizou-se da pesquisa bibliográfica e apresentou, também, como finalidade propiciar a abertura para novas pesquisas sobre fatores motivacionais no serviço público em busca da eficiência, além disso, por meio da aplicação das teorias motivacionais adequadas à realidade organizacional possibilitará uma implementação de melhorias. 1. Administração Pública. 2. Motivação. 3. Eficiência.
AVALIAÇÃO DA QUALIDADE DE FORMULAÇÕES FARMACÊUTICAS CONTENDO SULFATO FERROSO, DISPENSADAS NA REDE PÚBLICA DE SAÚDE
Authors: Yano Helena Miyoco , Pedron Cibele Nicolaski , Martins Valéria Adriana Pereira , Farias Fernanda Fernandes , Trujillo Luz Marina , Dias Nelson Aranha 
Published: July 2016

Para o controle e prevenção da anemia temporária de ferro na população, é recomendado seguir uma suplementação adequada, sendo o sulfato ferroso o principal fármaco de escolha. Considerando que este medicamento é distribuído pelo governo, principalmente para hospitais públicos e Unidades Básicas de Saúde (UBS), torna-se necessária a análise para verificação da qualidade em suas diversas formas farmacêuticas. Foi estabelecido entre o Instituto Adolfo Lutz e a Vigilância Sanitária de São Paulo, o Programa de Monitoramento de Qualidade de Medicamentos, como meio de garantir a qualidade, segurança e eficácia do medicamento. O objetivo do presente trabalho foi analisar sulfato ferroso em solução oral, xarope e comprimido e avaliar os resultados para detectar o impacto destes na saúde pública. As apresentações foram analisadas de acordo com monografias farmacopeicas quanto aos ensaios de aspecto, determinação de peso/volume/pH, identificação e teor de sulfato ferroso, e quanto à análise de rotulagem foi realizada de acordo com a legislação vigente. Os resultados das análises obtidas do Programa de Controle de Qualidade de Medicamentos e de queixas técnicas, no período de 2008-2014, foram: 57% considerados satisfatórios, e 43% insatisfatórios. Dentre os insatisfatórios, 7% estavam relacionados à análise de rotulagem, 18% ao aspecto e 18% relacionados ao ensaio de teor de sulfato ferroso. É de grande importância para a saúde pública, a continuidade destes programas de controle de qualidade de medicamentos, para que se assegure a manutenção de Boas Práticas de Fabricação (BPF), a fim de proteger e promover a saúde da população.
AVALIAÇÃO DA QUALIDADE DE COMPRIMIDOS DE ALPRAZOLAM 0,5 MG: ESTUDO COMPARATIVO ENTRE MEDICAMENTOS DE REFERÊNCIA, GENÉRICO E SIMILAR
Authors: Do Nascimento Aristides Avilo , Araújo Cardoso Nayara , Azevedo Rodrigues Glenda , Loiola Vasconcelos Thalles Yuri , Bezerra Sampaio Marques Francisca Valéria , E Vasconcelos de Lima Eloi , Mendes Josiane Lima 
Published: July 2016

Cerca de 20 % da população brasileira é afetada por transtornos de ansiedade, sendo mais prevalente entre mulheres, com idade entre 34 e 59 anos e o alprazolam é o segundo ansiolítico mais utilizado para tratar essa patologia. Quanto às características dos comprimidos, estes devem possuir estabilidades física e química, desintegrar-se no tempo esperado, ser pouco friáveis, além de apresentarsuperfície lisa e brilhante. O objetivo deste trabalho foi avaliar a qualidade de comprimidos de alprazolam 0,5 mg, efetuando a comparação entre medicamentos de referência, genérico e similar disponíveis comercialmente, quanto ao aspecto visual e aos ensaios de peso médio, dureza e friabilidade. Foram utilizados 270 comprimidos não revestidos de alprazolam 0,5 mg, provenientes de três laboratórios diferentes, sendo que 90 destes eram comprimidos de referência (grupo A), 90 genéricos (grupo B) e 90 similares (grupo C). Cada grupo era integrado por três subgrupos, de lotes diferentes, e cada subgrupo continha 30 comprimidos do mesmo lote, sendo em triplicata os ensaios. Assim, o grupo A foi constituído pelos lotes A1, A2 e A3; o grupo B foi integrado pelos lotes B1, B2 e B3 e o grupo C foi composto pelos lotes C1, C2 e C3. Todos os lotes foram aprovados nos testes de peso médio e friabilidade. Entretanto, na análise do aspecto visual, os medicamentos do grupo C presentaram lote e data de validade ilegíveis e no teste de dureza, dois comprimidos do lote C1 apresentaram dureza abaixo das especificações descritas pela Farmacopeia Brasileira 5ª edição.
Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid
Authors: Calderón Guzmán David , Brizuela Norma Osnaya , Ortíz Herrera Maribel , Hernández García Ernestina , Barragán Mejía Gerardo , Juárez Olguín Hugo , Valenzuela Peraza Armando , Attilus Jonas , Labra Ruíz Norma 
Published: July 2016

Abstract
The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex. The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.
PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation
Authors: Mabeta Peace 
Published: July 2016

Abstract
PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells.
The treatment of endothelioma cells with PF573,228 reduced their growth with an IC50 of approximately 4.6 μmol L-1 and inhibited cell migration with an IC50 of about 0.01 μmol L-1. Microscopic studies revealed morphological attributes of apoptosis. These observations were confirmed by ELISA, which showed increased caspase-3 activity. PF573,228 also inhibited angiogenesis in a dose-dependent manner, with an IC50 of approximately 3.7 μmol L-1, and abrogated the phosphorylation of cell survival proteins, proline-rich Akt substrate (PRAS40) and S6 ribosomal protein (S6RP). Array data further revealed that PF573,228 induced caspase-3 activation, thus promoting apoptosis. Since all the processes inhibited by PF573,228 provide important support to tumor survival and progression, the drug may have a potential role in the treatment of vascular tumors.