bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quadruple helix model of entrepreneurship, innovation and stages of economic development
Authors: Galvão Anderson , Mascarenhas Carla , Gouveia Rodrigues Ricardo , Marques Carla Susana , Leal Carmem Teresa 
Published: May 2017

Purpose
The purpose of this paper is to study the role of entrepreneurship in economic development based on the four dimensions of the quadruple helix model (Government, University, Enterprise and Society) in relation to the three stages of economy defined by the GEM (innovation-, efficiency- and factor-driven economies). In this context, the authors considered a set of variables that allowed them to measure and verify the stimulus that the four helixes represent in economic development.

Design/methodology/approach
This study was supported on secondary data from the GEM platform for 58 countries, for 2015. SPSS software was used to analyze data, which allowed the use of the ANOVA and Kruskall-Wallis tests, as well as the generalized linear regression.

Findings
The results show that in the factor-driven economies, there is a greater influence by the industry, while in the efficiency-driven economies, there is homogeneity among the four dimensions, highlighting only the variables “R&D transfer” and “Entrepreneurial Intention”. Because of the constant need for innovation to become more competitive, in the innovation-driven economies, business and government are the most important dimensions.

Research limitations/implications
Both in the scientific community with future empirical studies that can confirm the relevance of this model to better understanding which dimensions of quadruple helix improve economic development, and in the governmental community, to serve for policies and strategies that stimulate entrepreneurship to foster the transition from one stage of economic development to another.

Originality/value
Proposal and test of a quadruple helix model, using the variables available in the GEM database, to the three stages of economic development of the economies that were involved in the GEM.
Models and strategies of family businesses internationalization
Authors: Rexhepi Gadaf , Ramadani Veland , Rahdari Amir , Anggadwita Grisna 
Published: May 2017

PurposeThis paper aims to emphasize the importance of crafting and selecting business models and strategies of family business in the process of internationalization.Design/methodology/approachBased on literature review about international entrepreneurship, strategic management, models and strategies of internationalization, a new conceptual framework on family businesses internationalization is provided.FindingsFamily businesses, depending on their size, use different models and strategies to internationalize their activities.Originality/valueThis paper provides a new conceptual framework about internationalization of family businesses, which is based in three main phases: operating in a domestic market and get prepared for a foreign market, selecting the right model of internationalization and selecting the right strategy of internationalization. Beside the new conceptual model, the authors provide the implications of this model toward internationalization of family businesses, and the authors propose some useful recommendation for further research in this field.
Innovativeness in family firms: an internationalization approach
Authors: Ratten Vanessa , Tajeddini Kayhan 
Published: May 2017

PurposeThis paper aims to build on opportunity identification and resource-based view theory, this paper examines the internationalization process of family firms. The role of innovativeness in influencing the internationalization rate of family firms is explored in terms of customer responsiveness, proactiveness and risk-taking.Design/methodology/approachMultiple case studies were carried out with several family businesses in the information technology industry in Australia.FindingsThe findings of this research suggest that innovativeness of family firms depends on responsiveness to customer needs in the international market while involving a degree of risk-taking. In addition, the results suggest family firms are not proactive in their pursuit of international market opportunities.Research limitations/implicationsIf family firms focus more on becoming more innovative, then they will stand a better chance to successfully enter more international markets.Originality/valueThe paper highlights the need for family firms to embrace their innovativeness as a distinctive capability for their internationalization efforts. Several new research directions that may enhance the understanding of family firm innovation and internationalization are suggested.
Customer relationship management research in tourism and hospitality: a state-of-the-art
Authors: Rahimi Roya , Köseoglu Mehmet Ali , Ersoy Ayse Begum , Okumus Fevzi 
Published: May 2017

PurposeThis study aimed to provide a critical review of the evolution of customer relationship management (CRM) research in the hospitality and tourism (H&T) field.Design/methodology/approachThe study conducted a thorough systematical literature review by collecting papers from 14 leading tourism and hospitality journals. The examination of the literature is first based on the evolution of CRM notion and its definitions. Next, CRM studies in the literature that are related to H&T were assessed based on their timelines and themes. Third, the studies were classified based on CRM components and its impacts on firms’ performances.FindingsThe literature review provided an in-depth understanding on the progress of CRM based on the selected topics and suggests a redesigned research agenda for scholars, graduate students and practitioners.ImplicationsThis study provides new and meaningful avenues for further research in CRM in H&T area.Originality valueCRM has a key role in business performance and increased customer satisfaction and retention, specifically in the context of the service industry. To date, scholars have produced an abundant number of CRM-related studies in tourism and hospitality journals. In this study, the progress of CRM research conducted in the tourism and hospitality sector is critically reviewed.
Perceived organizational support, work-family/family-work conflict and presenteeism in hotel industry
Authors: Arslaner Ebru , Boylu Yasin 
Published: May 2017

PurposeThe purpose of this paper is to examine the relationships between perceived organizational support, work-family conflict, family-work conflict and presenteeism in the context of hotel industry.Design/methodology/approachData were collected via survey administered to 402 employees of five-star hotels in Antalya, Turkey. Data were analyzed using SPSS package program.FindingsThe results showed that there was a significant and negative relationship between perceived organizational support and presenteeism and a significant and positive relationship between work-family/family-work conflict and presenteeism. Moreover, perceived organizational support had no significant effect on presenteeism, while work-family/family-work conflict had a significant effect on presenteeism.Practical implicationsHotels need a healthy and productive workforce to ensure customer satisfaction and increase the quality of service. Reducing work-family/family-work conflict and increasing organizations’ support to employees is critical for protecting employee health and eliminating presenteeism behavior.Originality/valueThis study provides organizations with practical and theoretical implications to improve employee health and productivity.
The Rise of Uber and Regulating the Disruptive Innovator
Authors: Dudley Geoffrey , Banister David , Schwanen Tim 
Published: May 2017

AbstractThe ride‐hailing company Uber has achieved extremely rapid global expansion by means of outmanoeuvring governments, regulators and competitors. The rise of the company has been based on a deliberate strategy of acting as a market disruptive innovator through a user friendly technology and making use of the ‘sharing economy’. These attributes are not unique, but are distinctively augmented by a relentless expansionary ambition and an ability to maintain the capacity to innovate. Uber has generated great political controversy, but the challenge for governments and regulators is to embrace the benefits of the disruptive innovator, while adopting an approach that takes into account the full range of impacts. For Uber, the challenge is to maintain its expansionary style as a disruptive innovator, while also redefining on its terms the political and public debate. The case study of London provides important insights into the dynamics of these processes.
Fatal Ingestion of Chlumsky Disinfectant Solution
Authors: Handlos Petr , Uvíra Matěj , Marecová Klára , Staňková Marie , Smatanová Margita , Dvořáček Igor , Joukal Marek 
Published: May 2017

AbstractA 32‐year‐old pregnant woman in the 25th week of pregnancy underwent oral glucose tolerance screening at the diabetologist's. Later that day, she was found dead in her apartment possibly poisoned with Chlumsky disinfectant solution (solutio phenoli camphorata). An autopsy revealed chemical burns in the digestive system. The lungs and the brain showed signs of severe edema. The blood of the woman and fetus was analyzed using gas chromatography with mass spectrometry and revealed phenol, its metabolites (phenyl glucuronide and phenyl sulfate) and camphor. No ethanol was found in the blood samples. Both phenol and camphor are contained in Chlumsky disinfectant solution, which is used for disinfecting surgical equipment in healthcare facilities. Further investigation revealed that the deceased woman had been accidentally administered a disinfectant instead of a glucose solution by the nurse, which resulted in acute intoxication followed by the death of the pregnant woman and the fetus.
At the Cross Section of Thrombotic Microangiopathy and Atypical Hemolytic Uremic Syndrome: A Narrative Review of Differential Diagnostics and a Problematization of Nomenclature
Authors: Åkesson Alexander , Zetterberg Eva , Klintman Jenny 
Published: May 2017

AbstractComplement‐mediated atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with high mortality and morbidity. Renal biopsies often indicate thrombotic microangiopathy (TMA). The condition is caused by an excessive activation of the alternative pathway leading to depositions of membrane attack complexes (MAC) on host cells. It may depend on mutations in complement components and regulatory proteins, or the formation of complement‐specific antibodies. Mainly, an environmental trigger (e.g. infection) is needed for the excessive response to develop. The clinical characteristics are more or less shared with a wide range of diseases manifesting with microangiopathic hemolytic anemia. Because of prior deficits in pathogenic understanding, associated nomenclature has been based on clinical symptoms. New knowledge challenges these symptomatic definitions; however, an outdated terminology is still being applied in clinical practice to various extents. With respect to gained insights, it is more advantageous to rebuild the concepts on etiological and pathogenic grounds. The need for more distinct definitions is even more urgent in the light of the effective treatment regimen with eculizumab for complement‐mediated aHUS. This review presents an up‐to‐date summary of the field of investigation, addresses the need for faster differential diagnostics and proposes a revised nomenclature based on the current pathogenic understanding.
Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials
Authors: Witkiewitz Katie , Pearson Matthew R. , Hallgren Kevin A. , Maisto Stephen A. , Roos Corey R. , Kirouac Megan , Wilson Adam D. , Montes Kevin S. , Heather Nick 
Published: May 2017

AbstractBackground and aimsThere is evidence that low‐risk drinking is possible during the course of alcohol treatment and can be maintained following treatment. Our aim was to identify characteristics associated with low‐risk drinking during treatment in a large sample of individuals as they received treatment for alcohol dependence.DesignIntegrated analysis of data from the Combined Pharmacotherapies and Behavioral Intervention (COMBINE) study, Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity) and the United Kingdom Alcohol Treatment Trial (UKATT) using repeated‐measures latent class analysis to identify patterns of drinking and predictors of low‐risk drinking patterns during treatment.SettingUnited States and United Kingdom.ParticipantsPatients (n = 3589) with alcohol dependence receiving treatment in an alcohol clinical trial were primarily male (73.0%), white (82.0%) and non‐married (41.7%), with an average age of 42.0 (standard deviation = 10.7).MeasurementsSelf‐reported weekly alcohol consumption during treatment was assessed using the Form‐90 and validated with biological verification or collateral informants.FindingsSeven patterns of drinking during treatment were identified: persistent heavy drinking (18.7% of the sample), increasing heavy drinking (9.6%), heavy and low‐risk drinking (6.7%), heavy drinking alternating with abstinence (7.9%), low‐risk drinking (6.8%), increasing low‐risk drinking (10.5%) and abstinence (39.8%). Lower alcohol dependence severity and fewer drinks per day at baseline significantly predicted low‐risk drinking patterns [e.g. each additional drink prior to baseline predicted a 27% increase in the odds of expected classification in heavy drinking versus low‐risk drinking patterns; odds ratio = 1.27 (95% confidence interval (CI) = 1.10, 1.47, P = 0.002]. Greater negative mood and more heavy drinkers in the social network were significant predictors of expected membership in heavier drinking patterns.ConclusionsLow‐risk drinking is achievable for some individuals as they undergo treatment for alcohol dependence. Individuals with lower dependence severity, less baseline drinking, fewer negative mood symptoms and fewer heavy drinkers in their social networks have a higher probability of achieving low‐risk drinking during treatment.
The cross talk between cervical carcinoma cells and vascular endothelial cells mediated by IL‐27 restrains angiogenesis
Authors: Zhang Bing , Xie Feng , Dong Chun‐Lin , Gu Chun‐Jie , Cheng Jiao , Wang Yuan , Xu Xi‐Zhong , Pu Hong , Wu Yi‐Bo , Qi Xiao‐Wei , Li Da‐Jin , Yu Jin‐Jin , Li Ming‐Qing 
Published: May 2017

ProblemTo explore whether cervical carcinoma cell‐derived interleukin‐27 (IL‐27) modulates the angiogenesis of vascular endothelial cells.Method of studyThe expression of IL‐27 in cervical cancer tissues and cervical cell lines was analyzed by immunohistochemistry, ELISA and flow cytometry. Then, the effects of IL‐27 on the proliferation and apoptosis‐related molecules and angiogenesis in vitro of human umbilical vein endothelial cells (HUVECs) were investigated. Finally, in vivo experiment was performed to further confirm the effects of IL‐27.ResultsCompared with cervicitis, the cervical cancer tissues highly expressed IL‐27. Both HeLa and CaSki cells secreted IL‐27, and HUVECs expressed low levels of IL‐27 receptors (IL‐27R). However, the co‐culture of cervical cell lines and HUVECs led to a significant elevation of IL‐27R on HUVECs. Co‐culturing with IL‐27‐overexpressed HeLa cells downregulated Ki‐67 and Bcl‐2 and upregulated Fas expression in HUVECs. In addition, overexpression of IL‐27 in HeLa cells and CasKi cells secreted less IL‐8 and could further restrict angiogenesis compared with control cells in vitro. In the subcutaneous tumorous model of C57/BL6 mouse, there were decreased vessel density and tumor volume when inoculation with IL‐27‐overexpressed TC‐1 cells.ConclusionThis study indicates that IL‐27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer.
Conventional and right‐sided screening for subcutaneous ICD in a population with congenital heart disease at high risk of sudden cardiac death
Authors: Alonso Pau , Osca Joaquín , Rueda Joaquín , Cano Oscar , Pimenta Pedro , Andres Ana , Sancho María José , Martinez Luis 
Published: May 2017

BackgroundInformation regarding suitability for subcutaneous defibrillator (sICD) implantation in tetralogy of Fallot (ToF) and systemic right ventricle is scarce and needs to be further explored. The main objective of our study was to determine the proportion of patients with ToF and systemic right ventricle eligible for sICD with both, standard and right‐sided screening methods. Secondary objectives were: (i) to study sICD eligibility specifically in patients at high risk of sudden cardiac death, (ii) to identify independent predictors for sICD eligibility, and (iii) to compare the proportion of eligible patients in a nonselected ICD population.MethodsWe recruited 102 patients with ToF, 33 with systemic right ventricle, and 40 consecutive nonselected patients. Conventional electrocardiographic screening was performed as usual. Right‐sided alternative screening was studied by positioning the left‐arm and right‐arm electrodes 1 cm right lateral of the xiphoid midline. The Boston Scientific ECG screening tool was utilized.ResultsIn high‐risk patients with ToF, eligibility was higher with right‐sided screening in comparison with standard screening (61% vs. 44%; p = .018). Eligibility in high‐risk right ventricle population was identical with both screening methods (77%, p = ns). The only independent predictor for sICD eligibility was QRS duration.ConclusionIn high‐risk patients with ToF, right‐sided implantation of the sICD could be an alternative to a conventional ICD. In patients with a systemic right ventricle, implantation of a sICD is an alternative to a conventional sICD.
Categorization and theoretical comparison of quantitative methods for assessing QT/RR hysteresis
Authors: Gravel Hugo , Curnier Daniel , Dahdah Nagib , Jacquemet Vincent 
Published: May 2017

BackgroundIn the human electrocardiogram, there is a lag of adaptation of the QT interval to heart rate changes, usually termed QT/RR hysteresis (QT‐hys). Subject‐specific quantifiers of QT‐hys have been proposed as potential biomarkers, but there is no consensus on the choice of the quantifier.MethodsA comprehensive literature search was conducted to identify original articles reporting quantifiers of repolarization hysteresis from the surface ECG in humans.ResultsSixty articles fulfilled our inclusion criteria. Reported biomarkers were grouped under four categories. A simple mathematical model of QT/RR loop was used to illustrate differences between the methods. Category I quantifiers use direct measurement of QT time course of adaptation. They are limited to conditions where RR intervals are under strict control. Category IIa and IIb quantifiers compare QT responses during consecutive heart rate acceleration and deceleration. They are relevant when a QT/RR loop is observed, typically during exercise and recovery, but are not robust to protocol variations. Category III quantifiers evaluate the optimum RR memory in dynamic QT/RR relationship modeling. They estimate an intrinsic memory parameter independent from the nature of RR changes, but their reliability remains to be confirmed when multiple memory parameters are estimated. Promising approaches include the differentiation of short‐term and long‐term memory and adaptive estimation of memory parameters.ConclusionModel‐based approaches to QT‐hys assessment appear to be the most versatile, as they allow separate quantification of QT/RR dependency and QT‐hys, and can be applied to a wide range of experimental settings.
Case–control study shows that neonatal pneumococcal meningitis cannot be distinguished from group B Streptococcus cases
Authors: Arfi Alexandra , Cohen Robert , Varon Emmanuelle , Béchet Stéphane , Bonacorsi Stéphane , Levy Corinne 
Published: May 2017

AbstractAimStreptococcus pneumoniae (S. pneumoniae) is sometimes implicated in neonatal bacterial meningitis. This study described the demographic, clinical and biological features of neonatal S. pneumoniae meningitis and compared pneumococcal and group B streptococcal (GBS) neonatal meningitis.MethodsWe conducted a case–control study that compared neonates, aged one to 28 days with S. pneumoniae meningitis or GBS meningitis. Each case with S. pneumoniae was randomly matched to four control patients with GBS by age group and study year.ResultsFrom 2001 to 2013, the national French paediatric network, which comprises 227 paediatric wards, recorded 831 neonatal cases of meningitis. S. pneumoniae (n = 18, 2.2%) was the fifth infection cause after GBS (n = 464, 55.8%), Escherichia coli (n = 232, 27.9%), Neisseria meningitidis (n = 23, 2.8%) and Listeria monocytogenes (n = 20, 2.4%). Neonatal pneumococcal and GBS meningitis did not differ in demographic data or clinical and biological characteristics. All S. pneumoniae strains were fully susceptible to cefotaxime, and we observed a decrease of 13‐valent pneumococcal conjugate vaccine (PCV13) serotypes (88.9%–20.0%) after PCV13 implementation.ConclusionClinically and biologically, neonatal pneumococcal meningitis could not be distinguished from GBS cases. A herd effect of PCV13 implementation was suggested by the decrease in the prevalence of vaccine serotypes.
AN EMPIRICAL NOTE ON COMMUTING DISTANCE AND SLEEP DURING WORKWEEK AND WEEKEND
Authors: Pfeifer Christian 
Published: May 2017

ABSTRACTThe author uses six years of large‐scale panel survey data for Germany to analyse the nexus between commuting distance from the place of residence to the workplace and quantity of sleep. Pooled and individual fixed‐effects regressions indicate that workers with longer commuting distance sleep significantly less per night during the workweek, but not less during the weekend. A one kilometer longer commuting distance is on average correlated with 0.0035 (pooled) and 0.0011 (fixed‐effects) hours less sleep per night during the workweek. As commuting seems to affect sleep quantity, it might negatively affect health and time allocation for other leisure activities.
Clinical characteristics and factors associated with mortality in idiopathic pulmonary fibrosis: An experience from a tertiary care center in Pakistan
Authors: Zubairi Ali Bin Sarwar , Ahmad Huzaifa , Hassan Maryam , Sarwar Sajjad , Abbas Aamir , Shahzad Talha , Irfan Muhammad 
Published: May 2017

AbstractIntroductionIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) that predominantly affects older adults. IPF has the highest mortality burden of all ILDs. Data on mortality in patients with IPF is limited in developing countries.ObjectivesTo identify factors associated with mortality in patients with IPF at a tertiary care center in Pakistan.MethodsA retrospective chart review was conducted at the Aga Khan University Hospital (AKUH) in Karachi, Pakistan from January 2005 to December 2015. Patients were assessed for smoking status, clinical onset of disease, pulmonary hypertension, disease severity based on spirometry and hypoxemia.ResultsA total of 239 cases were reviewed, of which 103 were non‐survivors. A total of 45 (18%) were current smokers and 71 (29.7%) were ex‐smokers. Smoking was more common in non‐survivors (56.3% P ≤ .01). Pulmonary hypertension was present in 18.8% of patients. 95.4% of patients who had received pirfenidone treatment were alive at the time of study. On multivariate analysis, pirfenidone treatment (OR 0.03; 95% CI 0.01‐0.08), current smoking (OR 2.60; 95% CI 1.04‐6.58), age older than 60 years (OR 2.63; 95% CI 1.04‐6.58) and hypoxemia (OR 3.29; 95% CI 1.58‐6.84) were the factors associated with mortality.ConclusionSmoking, age greater than 60 years and hypoxemia were identified as factors that increased the odds of mortality in IPF patients, whereas pirfenidone was found to lower the odds of mortality.