bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequestered lumbar disc herniation mimicking spinal tumor
Authors: Biasi Pedro Radalle , Mallmann Adroaldo Baseggio , Crusius Paulo Sérgio , Seibert Cláudio Albano , Crusius Marcelo Ughini , Crusius Cassiano Ughini , Espanhol Rafael Augusto , Brunet Matheus Pintos , Carazzo Charles André 
Published: January 2018

AbstractThe occurrence of herniated disc simulating diseases in neuroimaging it's an uncommon situation. However, due to changes that occur in sequestered disc fragment, some cases can mimic spinal neoplasms. Thus, we present the case of a female patient, 60 year-old, with left back pain and left leg weakness. Left lower limb presented with strength grade IV, positive 45 degress Lasègue's signal and patellar areflexia. Lumbar spine magnetic resonance imaging (MRI) showed an expansive left centro-lateral lesion at L4-L5 level, hypointense on T1W, hyperintense on T2W, with peripheral contrast uptake, causing compression of the dural sac and L5 nerve root. A hemilaminectomy was performed, with complete excision of the lesion. Histological analisys confirmed discal hernia. Disc herniation is a condition characterized by the displacement of the disc content to the spinal canal, predominantly in the lumbar region, and manifesting as radiculopathy. The fragment sequestration occurs in 30% of the cases and is characterized by loss of continuity with remaining disc. MRI exams generally allow diagnostic confirmation; however, there may be diagnostic confusion with tumors, arachnoid cysts and abscesses. The inflammatory reaction occurred in the disc fragment produces the differences in MRI signal. The fragment is hypointense on T1W, hyperintense on T2W, with peripheral enhancement after contrast. Malignancies and Schwannomas have homogeneous or heterogeneous uptake. The epidural abscess is isointense on T1W and hyperintense on T2W, with homogeneous or peripheral enhancement, similar to discal herniation. Thus, sequestered disc herniation can mimic other space-occupying lesions, being necessary a surgical approach to obtain material for histopathological analysis and diagnostic confirmation.
Tophaceous gout of the spine: a neurosurgical standpoint
Authors: Ferreira Lobão Carlos Augusto , Bastos Albedy Moreira , Santos Rafael Brito , Duarte Cavalcante Eduardo Anderson 
Published: January 2018

Abstract
Objective: The study aim is to present the clinical, radiological aspects and treatment of this disease from the neurosurgical standpoint using a literature review and an illustrative case. Methods: A PubMed research was done with the terms “tophaceous gout”, “spine”, and “diagnosis”. We reviewed these articles and compared it with an illustrative case here presented. Results: According to a research done, this is the fifty-second case of tophaceous gout of the spine described in the English literature. The case and literature review presented demonstrate the difficulty in diagnosis, especially when the patient has no previous history of gout. Conclusion: It is important to consider tophaceous gout of the spine among the differential diagnoses that occur in the spine. Clinical and neurosurgical treatment may be required considering each case.
Lesões traumáticas do nervo óptico
Authors: Cannoni Luiz Fernando , Haddad Luciano , Esteves Veiga José Carlos 
Published: January 2018

Resumo
Objetivo: Documentar a incidência de lesões traumáticas da via óptica, assim como a etiologia traumática; correlacionar as lesões do nervo óptico com achados radiológicos (lesões cranianas e intracranianas); e estudar lesões múltiplas de nervos cranianos. Métodos: Dezoito pacientes admitidos no Serviço de Emergência da Santa Casa de Misericórdia de São Paulo com lesão traumática da via óptica foram incluídos. Os pacientes foram divididos em três grupos de acordo com o escore da Escala de Coma de Glasgow (ECG) em: trauma leve (ECG de 13 a 15), moderado (ECG de 9 a 12) e grave (ECG de 3 a 8), distribuição quanto a gênero, presença de fraturas, lesões intracranianas, fístulas liquóricas e mecanismo de trauma. Resultados: Dos 18 casos, 17 lesões ocorreram em conjunto com outros nervos cranianos e em 1 caso houve lesão exclusiva do nervo óptico. Atropelamentos, acidentes automobilísticos, motociclísticos e ferimento por projétil de arma de fogo constituíram as causas mais frequentes de lesão do nervo óptico, de forma isolada, assim como nas lesões de múltiplos nervos. Hematomas extradurais e contusões cerebrais foram as lesões intracranianas mais frequentes e, quando presentes, as fraturas cranianas localizavam-se no teto orbitário ou na região frontal. Conclusão: Neuropatia traumática do óptico deve ser pesquisada à admissão do paciente (quando possível), pois é passível de tratamento clínico (corticoides) ou cirúrgico. Achados sugestivos de neuropatia óptica traumática incluem fraturas do assoalho ou teto orbitário e traumas de alta energia cinética.
Devemos monitorar a pressão intracraniana de pacientes com TCE grave Marshall II?
Authors: Braga Bernardo Drummond , Rezende-Neto João Batista , Oliveira Marcelo Magaldi , Cardoso Bicalho Geraldo Vitor , Santiago Gustavo Zola , Cadurin Ariana Costa , Fernandes Diego José , Gomes Oliver Vilela , Faleiro Rodrigo Moreira 
Published: January 2018

Resumo
Objetivos: Avaliar a relação da PIC com o crescimento de lesões e morbimortalidade em pacientes Marshall II e determinar a necessidade de sua monitorização. Método: Estudo de coorte observacional prospectivo em pacientes com TCE grave classificados como Marshall II. Resultados: Setenta pacientes foram divididos em dois grupos baseados na PIC; G1: PIC ≤ 20 mmHg (49 pacientes) e G2 PIC > 20 mmHg (21 pacientes). Os achados mais comuns foram hemorragias subaracnóideas e contusões. A mortalidade foi maior em G2 que em G1 (OR: 11,7) (IC 95%: 2,2 a 63,1). A mediana da Escala de Desfecho de Glasgow após 90 dias foi de 2 para o G2 e de 5 para o G1. O surgimento ou progressões de lesões ocorreram em 71% dos pacientes no G2 contra 10% no G1 (p < 0,05). Em comparação ao G1, o OR de um novo achado na TC foi 22 vezes maior no G2 (IC 95%: 5,02 a 106,9). Dois pacientes do G2 precisaram de cirurgia e nenhum do G1. Conclusões: Pacientes Marshall II, com hipertensão intracraniana, apresentam maior risco para crescimento de lesões na TC de controle, pior prognóstico e maior mortalidade que aqueles sem hipertensão. A monitorização desses pacientes foi definitiva para determinar o prognóstico. Pacientes Marshall II devem ser monitorados.
Perfil epidemiológico de malformações arteriovenosas encefálicas em uma série monocêntrica
Authors: Nogueira Danilo Marques , Diniz Aron Athaide , Motta Deusdará Renato de Amorin , Kessler Iruena Moraes , Freire Neto Nelson Geraldo 
Published: January 2018

Resumo
Objetivo: Avaliar o perfil epidemiológico dos pacientes atendidos na Unidade de Neurocirurgia do Hospital de Base do Distrito Federal (HBDF), unidade de referência de doenças cerebrovasculares no Distrito Federal, bem como os métodos multidisciplinares de tratamento utilizados e a evolução clínica. Métodos: Realizou-se a análise retrospectiva de 42 pacientes portadores de malformações arteriovenosas (MAV) encefálicas admitidos no Serviço de Neurocirurgia do HBDF entre agosto de 2007 e janeiro de 2012, tratados conservadoramente ou submetidos a algum tipo de intervenção: microcirurgia intracraniana, embolização, técnica combinada ou radiocirurgia. Resultados: A distribuição por gênero perfez uma relação de 1,1:1,0 (masculino:feminino). Houve predomínio da localização supratentorial (85%, 36/42). Conforme a Escala de Spetzler-Martin (ESM), evidenciou-se predomínio de graus intermediários (graus II, III e IV), totalizando 96% (40/42). Dez pacientes (24%, 10/42) foram submetidos a tratamento cirúrgico convencional, 22 pacientes (52%, 22/42) à embolização (tratamento endovascular), 1 paciente (2,38%, 1/42) a tratamento combinado (endovascular e cirurgia), 1 (2,38%, 1/42) à radiocirurgia e 8 pacientes (19,05%, 8/42) foram tratados conservadoramente. A evolução clínica caracterizada pela Escala Modificada de Rankin (EMR) mostrou semelhança estatística em relação aos diversos tratamentos estabelecidos. Conclusão: As MAVs são lesões congênitas que, apesar de baixa prevalência, são alvo importante de estudo, por acometer principalmente adultos jovens e em idade produtiva. Este estudo, realizado em um centro de referência do Distrito Federal, evidencia características demográficas peculiares dessas lesões, que são compatíveis com dados prévios da literatura e mostra que a abordagem terapêutica multidisciplinar é essencial para seu correto tratamento.
Potencial evocado somatossensitivo transoperatório na malformação de Chiari. Relato de caso e argumentação
Authors: Junior Jefferson Rosi , Teixeira Manoel Jacobsen , Yeng Lin Tchia , Sékula Juliana Gozzo , Christ Carlos Daniel , de Andrade Daniel Ciampi , Montanaro Antônio Carlos , Dorsa de Oliveira Paulo Geraldo , Figueiredo Eberval Gadelha 
Published: January 2018

ResumoOs autores relatam o caso uma mulher de 23 anos, sintomática pela malformação de Chiari, submetida à descompressão cirúrgica da fossa posterior do crânio, com o transoperatório monitorizado por meio de potencial evocado somatossensitivo que auxiliou no resultado satisfatório obtido. É sugerido que as cirurgias para tratamento da malformação de Chiari sejam sempre monitorizadas por esse método.
Soziodemografisch stratifizierte Analyse der Nutzung sozialer Netzwerke und des Bewegungsverhaltens von juvenilen Adipositastherapieteilnehmern
Authors: Wulff Hagen , Wagner Petra 
Published: January 2018

ZusammenfassungDie Verbesserung bestehender Rehabilitationsansätze der juvenilen Adipositas setzt Kenntnisse über soziale und personale Voraussetzungen, Bedürfnisse und den Lebensstil, insbesondere über Aktivität und Mediennutzung voraus, um Inhalte und Methoden darauf auszurichten. Zu diesen Faktoren wurden 2013 mittels standardisierter Instrumente 510 11–17-jährige Patienten befragt. Körperliche Aktivitäten wurden von 64% mit Freunden und 43% im Verein ausgeführt. Mädchen (OR 0,55) und Kinder von Arbeitslosen (OR 0,28) hatten reduzierte Chancen auf Vereinssport. Insgesamt zeigten sich reduzierte Aktivitätsumfänge. Über digitale Medien wurden soziale Netzwerke, vorrangig Facebook, umfangreich genutzt. Die Nutzung der Netzwerkfunktionen unterschied sich in den soziodemografischen Gruppen. Die Patienten wünschten sich nach der Rehabilitation den Austausch untereinander (79%) und mit dem Therapeutenteam (37%). Die Ergebnisse weisen darauf hin, dass individualisierte Behandlungsansätze notwendig erscheinen.
Cannabis bei Parkinson – Hype oder
Heilmittel?
Authors: Mainka Tina , Stork Jan , Hidding Ute , Buhmann Carsten 
Published: January 2018

ZusammenfassungIn Deutschland können seit März 2017 Patienten mit einer schwerwiegenden
Erkrankung Cannabisblüten und -extrakte sowie synthetische Cannabinoide zu
Lasten der Krankenkassen verordnet werden. Die Zulassung von medizinischem
Cannabis beinhaltet keine Festlegung auf eine Indikation und ist somit auch für
Parkinson-Patienten relevant. Laut Gesetz haben schwerbetroffene Patienten sogar
einen Anspruch auf Versorgung mit medizinischem Cannabis, wenn übliche Maßnahmen
nicht erfolgreich waren oder nicht vertragen wurden oder „eine nicht ganz
entfernte Aussicht auf eine spürbare positive Einwirkung auf schwerwiegenden
Symptome besteht“.Vor diesem Hintergrund und verstärkt durch Medienberichte fragen zunehmend
Parkinson Patienten nach Verordnung von Cannabis. Dies stellt die behandelnden
Neurologen vor eine neue Herausforderung.Dieser Artikel gibt einen Überblick über die verschreibungsfähigen
Cannabisprodukte und Applikationsformen sowie die Datenlage für Cannabis bei
motorischen- und nicht-motorischen Parkinson Symptomen. Ferner werden aus Sicht
der Autoren Indikationen definiert, für welche im Einzelfall Cannabis bei
Parkinson-Patienten hilfreich sein könnte und ggf. dem Wunsch des Patienten nach
Verordnung stattgegeben werden sollte. Es werden praxisrelevante Empfehlungen
für die Verordnung von Cannabinoiden sowie die Beratung des Patienten,
einschließlich hinsichtlich der Fahrfähigkeit ausgesprochen.
Discourse management gestures
Authors: Wehling Elisabeth 
Published: January 2018

AbstractGestures that are used by interlocutors to manage the gist of their ‘discourse interactions’, namely content exchange and floor taking, can have one of two very different pragmatic functions: to signal inclusion and cooperation in friendly conversation, or to establish control in more argumentative conversation. While inclusive-cooperative gestures have been extensively studied (e.g.,Bavelas, Chovil, Lavrie, & Wade, 1992;Kendon, 1995;Müller, 2004;Sweetser, 1998), control gestures received little attention (although seeKendon, 1995,2004) until a recent spark of interest in their form and function (e.g.,Calbris, 2011;Müller, 2017;Wehling, 2010,2012,2013). However, even though research has detailed important aspects of such discourse managing gestures, to date no comprehensive account of their conceptual foundations and pragmatic functions exists. The present paper fills this gap in the literature. Building on prior analyses of control gestures in argumentative discourse (e.g.,Wehling, 2010) and inclusive-cooperative gestures in friendly conversation (e.g.,Bavelas et al., 1992;Müller, 2004), it details a typology ofdiscourse management gesturesthat distinguishesinclusive-cooperativeandcontrolgestures as separate pragmatic types and accounts for their forms and functions in terms of their conceptual foundations in primary metaphoric, space-motion schematic, and force dynamic reasoning.
Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010–2015
Authors: Sawadogo Souleymane , Shiningavamwe Andreas , Roscoe Clay , Baughman Andrew L , Negussie Taffa , Mutandi Gram , Yang Chunfu , Hamunime Ndapewa , Agolory Simon 
Published: January 2018

Abstract
Three hundred sixty-six adult patients in Namibia with second-line virologic failures were evaluated for human immunodeficiency virus drug-resistant (HIVDR) mutations. Less than half (41.5%) harbored ≥1 HIVDR mutations to standardized second-line antiretroviral therapy (ART) regimen. Optimizing adherence, viral load monitoring, and genotyping are critical to prevent emergence of resistance, as well as unnecessary switching to costly third-line ART regimens.
A Novel Hinged Scleral Patch Graft for the Repair of Overfiltration and Bleb Leaks
Authors: Mardelli Pierre G. , Mardelli Marc E. , Bakkour Zeina 
Published: January 2018

Introduction:
The repair of the scleral flap is often needed in cases of severe hypotony or bleb leaks with overfiltration. We present a simple novel technique to restore the hinged flap using a scleral patch graft.

Materials and Methods:
We present 4 eyes of 4 patients who presented with hypotony [intraocular pressure(IOP) <6 mm Hg] from overfiltration secondary to loose scleral flap (2 eyes) and bleb leak (2 eyes). A scleral patch from a human donor, preserved in 95% ethanol, was cut in a trapezoidal shape and placed over the area of filtration after a conjunctival peritomy. The scleral graft was secured anteriorly with a single double-armed 9-0 nylon suture in a double-mattress manner so as to create a hinged flap. Permanent or releasable sutures were placed posteriorly to control aqueous outflow.

Results:
All 4 patients had complete resolution of hypotony and bleb leaks with increase in their IOP to early teens. All maintained aqueous flow posteriorly with preservation of bleb function.

Conclusion:
Reestablishing the original anatomy of the hinged scleral flap can maintain bleb function without risk of overfiltration or loss of IOP control. This can be achieved through a simple repair using a scleral patch graft.
Expression of Gastrin Family Peptides in Pancreatic Islets and Their Role in β-Cell Function and Survival
Authors: Khan Dawood , Vasu Srividya , Moffett R. Charlotte , Irwin Nigel , Flatt Peter R. 
Published: January 2018

Objectives
Modulation of cholecystokinin (CCK) receptors has been shown to influence pancreatic endocrine function.

Methods
We assessed the impact of the CCKA and CCKB receptor modulators, (pGlu-Gln)-CCK-8 and gastrin-17, respectively, on β-cell secretory function, proliferation and apoptosis and glucose tolerance, and investigating alterations of CCK and gastrin islet expression in diabetes.

Results
Initially, the presence of CCK and gastrin, and expression of their receptors were evidenced in β-cell lines and mouse islets. (pGlu-Gln)-CCK-8 and gastrin-17 stimulated insulin secretion from BRIN-BD11 and 1.1B4 β-cells, associated with no effect on membrane potential or [Ca2+
]
i
. Only (pGlu-Gln)-CCK-8 possessed insulin secretory actions in isolated islets. In agreement, (pGlu-Gln)-CCK-8 improved glucose disposal and glucose-induced insulin release in mice. In addition, (pGlu-Gln)-CCK-8 evoked clear satiety effects. Interestingly, islet colocalization of CCK with glucagon was elevated in streptozotocin- and hydrocortisone-induced diabetic mice, whereas gastrin coexpression in α cells was reduced. In contrast, gastrin colocalization within β-cells was higher in diabetic mice, while CCK coexpression with insulin was decreased in insulin-deficient mice. (pGlu-Gln)-CCK-8 and gastrin-17 also augmented human and rodent β-cell proliferation and offered protection against streptozotocin-induced β-cell cytotoxicity.

Conclusions
We highlight the direct involvement of CCKA and CCKB receptors in pancreatic β-cell function and survival.
Quantitative super-resolution single molecule microscopy dataset of YFP-tagged growth factor receptors
Authors: Lukeš Tomáš , Pospíšil Jakub , Fliegel Karel , Lasser Theo , Hagen Guy M. 
Published: January 2018

BackgroundSuper-resolution single molecule localization microscopy (SMLM) is a method for achieving resolution beyond the classical limit in optical microscopes (approx. 200 nm laterally). Yellow fluorescent protein (YFP) has been used for super-resolution single molecule localization microscopy, but less frequently than other fluorescent probes. Working with YFP in SMLM is a challenge because a lower number of photons are emitted per molecule compared to organic dyes which are more commonly used. Publically available experimental data can facilitate development of new data analysis algorithms.FindingsFour complete, freely available single molecule super-resolution microscopy datasets on YFP-tagged growth factor receptors expressed in a human cell line are presented including both raw and analyzed data. We report methods for sample preparation, for data acquisition, and for data analysis, as well as examples of the acquired images. We also analyzed the SMLM data sets using a different method: super-resolution optical fluctuation imaging (SOFI). The two modes of analysis offer complementary information about the sample. A fifth single molecule super-resolution microscopy dataset acquired with the dye Alexa 532 is included for comparison purposes.ConclusionThis dataset has potential for extensive reuse. Complete raw data from SMLM experiments has typically not been published. The YFP data exhibits low signal to noise ratios, making data analysis a challenge. These data sets will be useful to investigators developing their own algorithms for SMLM, SOFI, and related methods. The data will also be useful for researchers investigating growth factor receptors such as ErbB3.
From Armament to Ornament: Performance Trade-Offs in the Sexual Weaponry of Neotropical Electric Fishes
Authors: Evans Kory M. , Bernt Maxwell J. , Kolmann Matthew A. , Ford Kassandra L. , Albert James S. 
Published: January 2018

AbstractThe evolution of sexual weaponry is thought to have marked effects on the underlying static allometry that builds them. These weapons can negatively affect organismal survivability by creating trade-offs between trait size and performance. Here we use three-dimensional geometric morphometrics to study the static allometry of two species of sexually dimorphic electric fishes (Apteronotus rostratus and Compsaraia samueli) in which mature males grow elongate jaws used in agonistic male-male interactions. We quantify jaw mechanical advantage between the sexes of both species to track changes in velocity and force transmission associated with the development of sexual weaponry. We find evidence for trade-offs between skull shape and mechanical advantage in C. samueli, where males with longer faces exhibit lower mechanical advantages, suggesting weaker bite forces. In contrast, males, and females of A. rostratus exhibit no difference in mechanical advantage associated with facial elongation. We hypothesize that differences in the functionality of the sexual weaponry between the two species may drive divergences in the allometric scaling of mechanical advantage.
Narrativity and its application in business ethics research
Authors: Lämsä Anna-Maija , Auvinen Tommi Pekka , Heikkinen Suvi Susanna , Sintonen Teppo 
Published: January 2018

Purpose
The purpose of this paper is to develop a narrative framework for doing empirical research into business ethics and shows, through two examples, how the framework can be applied in practice in this context. The focus is on interview-based research.

Design/methodology/approach
A theoretical research based on literature review was conducted.

Findings
In the developed narrative framework, two main kinds of analysis are distinguished: an analysis of the narrative and a narrative analysis. An analysis of the narrative is a matter of classifying and producing taxonomies out of the data. The purpose of a narrative analysis is to construct a story or stories based on the data. Narrative analysis differs from the analysis of narratives in that the story does not exist prior to the analysis, but is created during the analysis.

Research limitations/implications
The proposed narrative framework helps those doing empirical research into business ethics avoid simplistic “black and white” interpretations of their material, and helps them to show that ethical realities in the business world are often complex, various and multiple.

Practical implications
The paper offers a methodological framework for those doing qualitative research into business ethics which will increase the quality and rigor of their studies.

Originality/value
A value of the narrative approach is that the stories offer researchers an entry point to understanding the complexity of ethics and how people make sense of this complexity. The paper shows in detail how the methods presented can be used in practice in empirical research.