bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ageing, Chronic Disease and Injury: A Study in Western Victoria (Australia)
Authors: Sajjad M. Amber , Holloway Kara L. , Kotowicz Mark A. , Livingston Patricia M. , Khasraw Mustafa , Hakkennes Sharon , Dunning Trisha L. , Brumby Susan , Page Richard S. , Pedler Daryl , Sutherland Alasdair , Venkatesh Svetha , Brennan-Olsen Sharon L. , Williams Lana J. , Pasco Julie A. 
Published: August 2016

Background An increasing burden of chronic disease and associated health service delivery is expected due to the ageing Australian population. Injuries also affect health and wellbeing and have a long-term impact on health service utilisation. There is a lack of comprehensive data on disease and injury in rural and regional areas of Australia. The aim of the Ageing, Chronic Disease and Injury study is to compile data from various sources to better describe the patterns of chronic disease and injury across western Victoria. Design: Ecological study. Methods: Information on demographics, socioeconomic indicators and lifestyle factors are obtained from health surveys and government departments. Data concerning chronic diseases and injuries will be sourced from various registers, health and emergency services, local community health centres and administrative databases and compiled to generate profiles for the study region and for sub-populations within the region. Expected impact for public health: This information is vital to establish current and projected population needs to inform policy and improve targeted health services delivery, care transition needs and infrastructure development. This study provides a model that can be replicated in other geographical settings.
Maternal Deaths Databases Analysis: Ecuador 2003-2013
Authors: Pino Antonio , Albán María , Rivas Alejandra , Rodríguez Erika 
Published: August 2016

Background Maternal mortality ratio in Ecuador is the only millennium goal on which national agencies are still making strong efforts to reach 2015 target. The purpose of the study was to process national maternal death databases to identify a specific association pattern of variable included in the death certificate. Design and methods The study processed mortality databases published yearly by the National Census and Statistics Institute (INEC). Data analysed were exclusively maternal deaths. Data corresponds to the 2003-2013 period, accessible through INEC's website. Comparisons are based on number of deaths and use an ecological approach for geographical coincidences. Results The study identified variable association into the maternal mortality national databases showing that to die at home or in a different place than a hospital is closely related to women's socioeconomic characteristics; there was an association with the absence of a public health facility. Also, to die in a different place than the usual residence could mean that women and families are searching for or were referred to a higher level of attention when they face complications. Conclusions Ecuadorian maternal deaths showed Patterns of inequity in health status, health care provision and health risks. A predominant factor seems unclear to explain the variable association found processing national databases; perhaps every pattern of health systems development played a role in maternal mortality or factors different from those registered by the statistics system may remain hidden. Some random influences might not be even considered in an explanatory model yet.
Study of NWP parameterizations on extreme precipitation events over Basque Country
Authors: Gelpi Iván R. , Gaztelumendi Santiago , Carreño Sheila , Hernández Roberto , Egaña Joseba 
Published: August 2016

Abstract. The Weather Research and Forecasting model (WRF), like other numerical models, can make use of several parameterization schemes. The purpose of this study is to determine how available cumulus parameterization (CP) and microphysics (MP) schemes in the WRF model simulate extreme precipitation events in the Basque Country. Possible combinations among two CP schemes (Kain–Fritsch and Betts–Miller–Janjic) and five MP (WSM3, Lin, WSM6, new Thompson and WDM6) schemes were tested. A set of simulations, corresponding to 21st century extreme precipitation events that have caused significant flood episodes have been compared with point observational data coming from the Basque Country Automatic Weather Station Mesonetwork. Configurations with Kain–Fritsch CP scheme produce better quantity of precipitation forecast (QPF) than BMJ scheme configurations. Depending on the severity level and the river basin analysed different MP schemes show the best behaviours, demonstrating that there is not a unique configuration that solve exactly all the studied events.
Organization Citizenship and Employee Withdrawal Behavior in the Workplace
Authors: Smith J. R. , Micich Lisa A. , McWilliams Douglas L. 
Published: August 2016

The purpose of this research was to investigate the effect of organizational citizenship behaviors (altruism, courtesy, sportsmanship, generalized compliance and civic virtue) on employee withdrawal behaviors (turnover, absenteeism and tardiness). Most research in the OCB literature focused on the impact of organizational citizenship behaviors on turnover, with minimal attention directed toward absenteeism and tardiness, as negative employee performance behaviors. Data were obtained from employees (N = 334) at a municipal law enforcement agency with (N = 624) employees resulting in a 53.53% usable response rate. Data analysis indicated that job satisfaction was directly related to organizational citizenship behavior; and organizational citizenship behavior was inversely related to overall employee withdrawal behavior. Study findings did not lend support for organizational commitment being directly related to organizational citizenship behavior. The authors specified study limitations and future research opportunities.
Primary Salivary Human Stem/Progenitor Cells Undergo Microenvironment-Driven Acinar-Like Differentiation in Hyaluronate Hydrogel Culture
Authors: Srinivasan Padma Pradeepa , Patel Vaishali N. , Liu Shuang , Harrington Daniel A. , Hoffman Matthew P. , Jia Xinqiao , Witt Robert L. , Farach-Carson Mary C. , Pradhan-Bhatt Swati 
Published: August 2016

Abstract
Radiotherapy for head and neck cancer often has undesirable effects on salivary glands that lead to xerostomia or severe dry mouth, which can increase oral infections. Our goal is to engineer functional, three-dimensional (3D) salivary gland neotissue for autologous implantation to provide permanent relief. An immediate need exists to obtain autologous adult progenitor cells as the use of embryonic and induced pluripotent stem cells potentially pose serious risks such as teratogenicity and immunogenic rejection. Here, we report an expandable population of primary salivary human stem/progenitor cells (hS/PCs) that can be reproducibly and scalably isolated and propagated from tissue biopsies. These cells have increased expression of progenitor markers (K5, K14, MYC, ETV4, ETV5) compared with differentiation markers of the parotid gland (acinar: MIST1/BHLHA15 and AMY1A; ductal: K19 and TFCP2L1). Isolated hS/PCs grown in suspension formed primary and secondary spheres and could be maintained in long-term 3D hydrogel culture. When grown in a customized 3D modular hyaluronate-based hydrogel system modified with bioactive basement membrane-derived peptides, levels of progenitor markers, indices of proliferation, and viability of hS/PCs were enhanced. When appropriate microenvironmental cues were provided in a controlled manner in 3D, such as stimulation with β-adrenergic and cholinergic agonists, hS/PCs differentiated into an acinar-like lineage, needed for saliva production. We conclude that the stem/progenitor potential of adult hS/PCs isolated without antigenic sorting or clonal expansion in suspension, combined with their ability to differentiate into specialized salivary cell lineages in a human-compatible culture system, makes them ideal for use in 3D bioengineered salivary gland applications.
Documenter l’activité tutorale en situation de travail : pour une approche du « travail en actes »
Authors: Markaki Vassiliki , Rémery Vanessa 
Published: August 2016

Cette contribution vise à documenter l’activité tutorale en situation de travail à partir d’une analyse du « travail en actes » d’éducatrices de la petite enfance chargées d’accompagner des stagiaires au sein de structures d’accueil collectif. La manière dont s’opérationnalise la médiation du tuteur dans ces situations structurées par un travail interactionnel permanent se déploie selon des modalités particulières, éminemment indexées aux événements qui émergent, démultipliant par exemple les formats d’échanges entre les participants de la situation et reconfigurant en permanence l’organisation de l’activité en cours. Sur la base d’une série d’enregistrements audiovisuels, nous avons adopté une approche en analyse du travail centrée sur l’activité et l’interaction qui s’appuie sur les principes de l’analyse conversationnelle d’orientation ethnométhodologique. Une description fine des pratiques tutorales permet ainsi d’accéder aux manières dont les éducatrices, endossant un rôle de tutrice, transmettent des savoirs et des compétences professionnelles dans le cours même du travail.
L’activité des salariés d’agences de travail temporaire
Authors: Vultur Mircea 
Published: August 2016

Cet article se propose d’analyser l’activité des salariés d’agences de travail temporaire qui est la figure emblématique des nouvelles relations triangulaires, fort illustrative du contexte « connexionnel » où le travailleur est pris, de manière simultanée, entre plusieurs logiques d’action, sollicité de manière multiple par son environnement et interpellé par des cadres relationnels différenciés. Nous analysons le vécu de ces situations, en mettant l’accent sur le travail comme activité et non pas comme rapport social. Nous rendons compte de pratiques de travail perçues, de l’expérience vécue par les travailleurs d’agence à partir de la perception qu’ils ont de leur statut et de leurs conditions de travail. Les deux dimensions de l’analyse seront : a) la relation que les travailleurs d’agence entretiennent avec leur environnement spécifique de travail et b) les logiques de recours aux agences qui se situent en dissonance avec les conditions concrètes de l’activité de travail. Nous montrerons que l’activité est précaire et peu investie de sens et que le recours aux agences, stratégique ou hasardeux, tient peu compte des caractéristiques de l’activité, les travailleurs se trouvant dans un rapport « opportuniste » avec leur environnement de travail. Pour eux, le « vrai travail » se situe en dehors de l’« activité ». Nos analyses ont comme base un matériau empirique formé de quarante-deux entrevues avec des salariés d’agence réalisées en 2012-2013 dans les régions de Québec et de Montréal.
Interactions des personnes sans abri avec les services de police : profilage social et droits
Authors: Kauppi Carol , Pallard Henri , Ellery Vivan 
Published: August 2016

Dans le présent article, nous examinons les récits de 29 personnes sans abri afin de comprendre comment leurs interactions avec les policiers présentent des traits de profilage social et racial. Ces personnes sont des femmes et des hommes de 18 à 54 ans provenant du nord-est de l’Ontario. Les personnes autochtones forment la majeure partie de l’échantillonnage (66 %), tandis que les personnes anglophones, francophones ou membres de groupes racialisés en constituent des parts moins importantes. Les transcriptions des entrevues ont fait l’objet d’une analyse thématique qualitative afin d’identifier des thèmes d’interaction et de les coder. Nous examinons les cinq types d’interaction avec la police les plus communs selon deux aspects : premièrement, comment les personnes sans abri décrivent leurs mauvaises expériences d’interaction du point de vue du profilage social, y compris le profilage racial, et, deuxièmement, comment certaines actions de la police peuvent porter atteinte aux droits des personnes sans abri garantis par les articles 7 à 10 de la Charte canadienne des droits et libertés. Les résultats indiquent que le profilage social est un concept plus pertinent que le profilage racial lorsqu’on considère les expériences vécues par les personnes sans abri, étant donné que la police tend apparemment à cibler l’ensemble des personnes sans abri en leur infligeant un traitement éprouvant, voire violent, qui porte atteinte à leurs droits, notamment ceux garantis par la Charte.
Coordination ou coopération ? Deux approches paradigmatiques à la gestion d’un système de dualité
Authors: Bank Volker 
Published: August 2016

Chaque système éducatif requiert de la gestion et du pilotage, y compris le secteur vocationnel ou professionnel. Pourtant, les effets sur la logique didactique des telles organisations peuvent être très différents d’un secteur à un autre. Un dispositif d’éducation ou de formation par alternance requiert de la coordination ou de la coopération. En Allemagne, bien qu’on parle surtout de l’importance de la « coopération » depuis plus d’une décennie, le système dual s’est développé au sein de l’éducation vocationnelle ou professionnelle selon le principe d’une gestion par coordination. Le pilotage « par plans » a semblé l’approche la plus adéquate pour organiser ce système dual. À partir de l’idée d’une dualité didactique, nous pouvons démontrer les qualités nécessaires du pilotage « par plans » à des fins de coordination de logiques didactiques différentes.
High export via small particles before the onset of the North Atlantic spring bloom
Authors: Giering S. L. C. , Sanders R. , Martin A. P. , Lindemann C. , Möller K. O. , Daniels C. J. , Mayor D. J. , St. John M. A. 
Published: August 2016

AbstractSinking organic matter in the North Atlantic Ocean transfers 1–3 Gt carbon yr−1 from the surface ocean to the interior. The majority of this exported material is thought to be in form of large, rapidly sinking particles that aggregate during or after the spring phytoplankton bloom. However, recent work has suggested that intermittent water column stratification resulting in the termination of deep convection can isolate phytoplankton from the euphotic zone, leading to export of small particles. We present depth profiles of large (>0.1 mm equivalent spherical diameter, ESD) and small (<0.1 mm ESD) sinking particle concentrations and fluxes prior to the spring bloom at two contrasting sites in the North Atlantic (61.30°N, 11.00°W and 62.50°N, 02.30°W) derived from the Marine Snow Catcher and the Video Plankton Recorder. The downward flux of organic carbon via small particles ranged from 23 to 186 mg C m−2 d−1, often constituting the bulk of the total particulate organic carbon flux. We propose that these rates were driven by two different mechanisms. In the Norwegian Basin, small sinking particles likely reached the upper mesopelagic by disaggregation of larger, faster sinking particles. In the Iceland Basin, a storm deepened the mixed layer to >300 m depth, leading to deep mixing of particles as deep as 600 m. Subsequent restratification could trap these particles at depth and lead to high particle fluxes at depth without the need for aggregation (“mixed‐layer pump”). Overall, we suggest that prebloom fluxes to the mesopelagic are significant, and the role of small sinking particles requires careful consideration.
Zielgerichtete kovalente Inhibitoren für das Wirkstoffdesign
Authors: Baillie Thomas A. 
Published: August 2016

AbstractAbweichend vom üblichen Arzneimittelwirkmechanismus einer reversiblen, nichtkovalenten Wechselwirkung eines Liganden mit seinem biologischen Zielmolekül wird ein zielgerichteter kovalenter Inhibitor (TCI) so entwickelt, dass nach einer anfänglichen reversiblen Assoziation eine kovalente Bindung zwischen einem Elektrophil auf dem Liganden und einem nucleophilen Zentrum auf dem Protein geknüpft wird. Obwohl diese Methode einige potenzielle Vorteile bietet (hohe Wirksamkeit, verlängerte Wirkung), haben Bedenken wegen möglicher toxikologischer Folgen durch Proteinhaptenisierung die Entwicklung des TCI‐Konzepts aufgehalten. Neue Ansätze zur Verringerung des Risikos ernster ungünstiger Reaktionen regten das Interesse an diesem Gebiet an und führten zur Vertriebsgenehmigung für eine erste Serie von TCIs. Der Zugang über kovalente Inhibitoren wird daher rasch als nützliches Mittel in der Arzneimittelforschung akzeptiert werden und großen Einfluss auf das Design von Enzyminhibitoren und Rezeptormodulatoren ausüben.
Fullerene‐Based Macro‐Heterocycle Prepared through Selective Incorporation of Three N and Two O Atoms into C60
Authors: Li Yanbang , Zhang Gaihong , Wang Dian , Xu Beidi , Xu Dan , Lou Ning , Gan Liangbing 
Published: August 2016

AbstractA 14‐membered heterocycle is created on the C60 cage skeleton through a multistep procedure. Key steps involve repeated PCl5‐induced hydroxylamino N−O bond cleavage leading to insertion of nitrogen atoms, and also piperidine‐induced peroxo O−O bond cleavage leading to insertion of oxygen atoms. The hetero atoms form one pyrrole, two pyran, and one diazepine rings in conjunction with the C60 skeleton carbon atoms. The fullerene‐based macrocycle showed unique reactivities towards fluoride ion and copper salts.
Helpful Thoughts – Some Reflections on the Psychodynamic Treatment of Traumatized Refugees
Authors: Harnischfeger Jessica 
Published: August 2016

AbstractThis article discusses critically the focus on stress symptoms when treating traumatized refugees. It describes common challenges that practitioners meet, when working with extreme trauma. It suggests three concepts that might help to understand the complicated dynamics of severe traumatization. These concepts deal as well with the nature of post‐traumatic problems as with the way they might be treated. A clinical case is used to exemplify and discuss the concepts. Finally the article offers some thoughts on the special dynamics of the situation of refugees.
Effects of a hook ring on catch and bycatch in a Mediterranean swordfish longline fishery: small addition with potentially large consequences
Authors: Piovano Susanna , Swimmer Yonat 
Published: August 2016

Abstract

The purpose of this study was to investigate the effects of a circle hook ring on catch rates of target fish species and bycatch rates of sea turtles, elasmobranchs, and non‐commercial fish in a shallow‐set Italian swordfish longline fishery.
Results were compared from 65 sets from six commercial fishing vessels totalling 50 800 hooks in which ringed and non‐ringed 16/0 circle hooks with a 10° offset were alternated along the length of the longline. In total, 464 individuals were caught in the 4 years of experiment, with swordfish (Xiphias gladius) comprising 83% of the total number of animals captured. Catch rates of targeted swordfish were significantly higher on ringed hooks (CPUEringed hooks = 8.465, CPUEnon‐ringed hooks = 6.654).
Results indicate that ringed circle hooks captured significantly more small‐sized swordfish than non‐ringed circle hooks (27.7% vs. 19.5%, respectively).
For species with sufficient sample sizes, the odds ratio (OR) of a capture was in favour of ringed hooks; significantly for swordfish (OR = 1.27 95%CI 1.04–1.57), and not significantly for bluefin tuna (Thunnus thynnus) (OR = 1.50, 95%CI 0.68–3.42) nor for pelagic stingray (Pteroplatytrigon violacea) (OR = 1.13, 95%CI 0.54–2.36). All six loggerhead turtles (Caretta caretta) and three of the four blue sharks (Prionace glauca) were captured on ringed hooks, however, the small sample sizes prevented meaningful statistical analysis.
In summary, results from this study suggest that the addition of a ring to 16/0 circle hooks confers higher catchability for small‐sized commercial swordfish, and does not significantly reduce catch rate of bycatch species and protected species in a Mediterranean shallow pelagic longline fishery.
These findings should motivate fisheries managers to consider factors in addition to hook shape when aiming to promote sustainable fishing practices. The presence of a ring has the potential to negate some conservation benefits.
Copyright © 2016 John Wiley & Sons, Ltd.
A Convenient Palladium‐Catalyzed Carbonylative Synthesis of Benzofuran‐2(3 H)‐ones with Formic Acid as the CO Source
Authors: Qi Xinxin , Li Hao‐Peng , Wu Xiao‐Feng 
Published: August 2016

AbstractA general and convenient palladium‐catalyzed carbonylation procedure for the synthesis of benzofuran‐2(3 H)‐ones from phenols and aldehydes has been developed. With formic acid as the CO source, a variety of benzofuran‐2(3 H)‐ones were obtained in moderate to good yields.
The pivotal role of mammalian target of rapamycin inhibition in the treatment of patients with neuroendocrine tumors
Authors: Phan Alexandria T. , Dave Bhuvanesh 
Published: August 2016

AbstractSignificant advances have been made toward understanding the biology of neuroendocrine tumors (NET) in terms of defining prognosis and improving clinical management; however, many unmet needs remain. The treatment landscape for NET has evolved, with the approval of the targeted agents everolimus and sunitinib for the treatment of advanced pancreatic NET in 2011 followed by the approval of everolimus for the treatment of advanced nonfunctional gastrointestinal and lung NET in 2016. Mammalian target of rapamycin (mTOR) and components of the mTOR pathway play pivotal roles in NET pathogenesis. Effects of the mTOR inhibitor everolimus have been well documented in preclinical and clinical studies, both as monotherapy and combination therapy. mTOR inhibition as backbone therapy within the NET treatment landscape is a focus of continuing research, which includes evaluation of the growing armamentarium of approved and investigational agents as potential combination partners. Data evaluating the clinical benefits of agents targeting mTOR and related pathways (alone and in combination) in the treatment of patients with NET continue to increase. Many of the findings to date are encouraging.
The hedgehog pathway in triple‐negative breast cancer
Authors: Habib Joyce G. , O'Shaughnessy Joyce A. 
Published: August 2016

AbstractTreatment of triple‐negative breast cancer (TNBC) remains challenging due to the underlying heterogeneity of this disease coupled with the lack of predictive biomarkers and effective targeted therapies. Intratumoral heterogeneity, particularly enrichment for breast cancer stem cell‐like subpopulations, has emerged as a leading hypothesis for systemic therapy resistance and clinically aggressive course of poor prognosis TNBC. A growing body of literature supports the role of the stem cell renewal Hedgehog (Hh) pathway in breast cancer. Emerging preclinical data also implicate Hh signaling in TNBC pathogenesis. Herein, we review the evidence for a pathophysiologic role of Hh signaling in TNBC and explore mechanisms of crosstalk between the Hh pathway and other key signaling networks as well as their potential implications for Hh‐targeted interventions in TNBC.