bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short- and long-term metabolic responses to diets with different protein:carbohydrate ratios in Senegalese sole (Solea senegalensis, Kaup 1858)
Authors: Conde-Sieira Marta , Salas-Leiton Emilio , Duarte Marta M. , Pelusio Nicole F. , Soengas José L. , Valente Luísa M. P. 
Published: April 2016

AbstractFour isolipidic and isoenergetic diets with different protein:carbohydrate (CH) contents (48:38, 52:34, 56:30, 60:26) were fed to juvenile Senegalese sole (22·01 (sem0·01) g) during 104 d. Oral glucose tolerance tests were performed at the beginning (4 d) and at the end (104 d) of the experiment to assess the effect of the dietary treatment on glucose tolerance. Samples of blood, liver and muscle of all dietary groups were also obtained at the initial and final phases of the trial at different postprandial times (0, 1, 5 and 10 h after feeding) in order to analyse glucose and NEFA in plasma, and metabolites and enzyme activities involved in glycogen metabolism, glycolysis, gluconeogenesis and lipogenesis pathways in liver and muscle. The results obtained in this study suggest a good glucose tolerance in Senegalese sole. This species tolerated important amounts of CH in the diet without showing any deleterious signs in terms of growth or any metabolic disorders. After 104 d of feeding diets with an important amount of CH (48:38 and 52:34), the control of glycaemia was maintained and even postprandial glucose levels in plasma were (in general) lower than at the beginning of the experiment. This reasonable tolerance to glucose is also reflected by an increased use of glucose through glycolysis in liver (indicated by glucokinase activity), and the absence of changes in lipogenic potential in the same tissue (indicated by ATP citrate lyase activity). No clear changes were induced in the muscle by the dietary treatments.
A Patchwork of Participation: Stewardship, Delegation and the Search for Community Representation in Post-Amalgamation Ontario
Authors: Spicer Zachary 
Published: April 2016

AbstractIn the wake of wide-ranging municipal amalgamations Ontario, the provincial government promoted the use of community councils, citizen-led boards that would have input in local matters. Community councils were touted as a way of preserving local identity and policy control. However, more than a decade removed from Ontario's restructuring process, few municipalities have community councils in place. Those that have implemented community councils established them with purely advisory functions. This paper asks why community councils were so inconsistently implemented and introduced with such limited powers. Overall, it is found that community councils were victims of restructuring politics. Blocked by city councillors fearing decentralization would dilute their authority and foster political rivals, constrained through a restrictive legislative framework and pushed aside by city officials fearing they would effectively recreate a two-tier system, community councils were either abandoned or installed with a limited mandate.
Placing Madagascar's marine turtle populations in a regional context using community-based monitoring
Authors: Humber Frances , Godley Brendan J. , Nicolas Tanguy , Raynaud Olivier , Pichon Florence , Broderick Annette 
Published: April 2016

AbstractMadagascar is an important foraging ground for marine turtles in the Western Indian Ocean, yet the status of the country's nesting aggregations remains poorly documented. We assess the current status and trend in nesting throughout Madagascar, including data recorded by a community-based monitoring project in the Barren Isles (western Madagascar). We contextualize the findings in comparison with data from Madagascar's closest neighbouring states. Reports indicate that nesting levels have declined at many coastal sites, with no known recordings since 2000 at > 40 nesting sites. We estimate there are a minimum of 1,200 nests per year in Madagascar, with the largest recorded nesting aggregation (< 1,000 nests per year) found on islands off the west and northern coasts. The majority of nesting aggregations, including those recorded by the community-based monitoring project in the Barren Isles, are relatively small, in the order of < 50 nests per year, yet they are potentially important sources of regional genetic diversity. Nesting on many of the islands (e.g. Tromelin, Europa) around Madagascar has increased over the last 20 years, despite the fact that thousands of turtles probably originating from these sites are taken by fishers in the waters of Madagascar annually. We discuss the importance of protecting small nesting populations, and how community-based monitoring could be an important tool for conserving remote and vulnerable populations and building capacity for natural resource management.
Negative covariance between parasite load and body condition in a population of feral horses
Authors: DEBEFFE LUCIE , MCLOUGHLIN PHILIP D. , MEDILL SARAH A. , STEWART KATHRINE , ANDRES DANIEL , SHURY TODD , WAGNER BRENT , JENKINS EMILY , GILLEARD JOHN S. , POISSANT JOCELYN 
Published: April 2016

SUMMARYIn wild and domestic animals, gastrointestinal parasites can have significant impacts on host development, condition, health, reproduction and longevity. Improving our understanding of the causes and consequences of individual-level variation in parasite load is therefore of prime interest. Here we investigated the relationship between strongyle fecal egg count (FEC) and body condition in a unique, naturalized population of horses that has never been exposed to anthelmintic drugs (Sable Island, Nova Scotia, Canada). We first quantified variation in FEC and condition for 447 individuals according to intrinsic (sex, age, reproductive status, social status) and extrinsic (group size, location, local density) variables. We then quantified the repeatability of measurements obtained over a field season and tested for covariance between FEC and condition. FECs were high relative to other horse populations (mean eggs per gram ± SD = 1543·28 ± 209·94). FECs generally decreased with age, were higher in lactatingvsnon-lactating females, and unexpectedly lower in males in some part of the island. FECs and condition were both spatially structured, with patterns depending on age, sex and reproductive status. FECs and condition were both repeatable. Most notably, FECs and condition were negatively correlated, especially in adult females.
Dengue and chikungunya: modelling the expansion of mosquito-borne viruses into naïve populations
Authors: WEARING HELEN J. , ROBERT MICHAEL A. , CHRISTOFFERSON REBECCA C. 
Published: April 2016

SUMMARYWith the recent global spread of a number of mosquito-borne viruses, there is an urgent need to understand the factors that contribute to the ability of viruses to expand into naïve populations. Using dengue and chikungunya viruses as case studies, we detail the necessary components of the expansion process: presence of the mosquito vector; introduction of the virus; and suitable conditions for local transmission. For each component we review the existing modelling approaches that have been used to understand recent emergence events or to assess the risk of future expansions. We identify gaps in our knowledge that are related to each of the distinct aspects of the human-mosquito transmission cycle: mosquito ecology; human–mosquito contact; mosquito–virus interactions; and human–virus interactions. Bridging these gaps poses challenges to both modellers and empiricists, but only through further integration of models and data will we improve our ability to better understand, and ultimately control, several infectious diseases that exert a significant burden on human health.
JÖRG WIDMANN'S JAGDQUARTETT
Authors: Armstrong Asher Ian 
Published: April 2016

AbstractJörg Widmann's work embraces everything music history – and beyond – has to offer: Lachenmann, Boulez, the poetry of Baudelaire, Rilke's Late Sonnets and the Screaming Pope paintings of Francis Bacon. His transformative re-imagining of traditional forms is seen nowhere better than in the Jagdquartett, the third in a cycle of five quartets that comprise the core of his œuvre. In the interview around which this article is based he discusses the Jagdquartett and its inspirations in detail, and the possibility of his music representing a kind of meta-modernism.
Forward projection model of non-central catadioptric cameras with spherical mirrors
Authors: Goncalves Nuno , Nogueira Ana Catarina , Miguel Andre Lages 
Published: April 2016

SUMMARYNon-central catadioptric vision is widely used in robotics and vision but suffers from the lack of an explicit closed-form forward projection model (FPM) that relates a 3D point with its 2D image. The search for the reflection point where the scene ray is projected is extremely slow and unpractical for real-time applications. Almost all methods thus rely on the assumption of a central projection model, even at the cost of an exact projection.Two recent methods are able to solve this FPM, presenting a quasi-closed form FPM. However, in the special case of spherical mirrors, further enhancements can be made. We compare these two methods for the computation of the FPM and discuss both approaches in terms of practicality and performance. We also derive new expressions for the FPM on spherical mirrors (extremely useful to robotics and graphics) which speed up its computation.
The role of emotion regulation in childhood obesity: implications for prevention and treatment
Authors: Aparicio E. , Canals J. , Arija V. , De Henauw S. , Michels N. 
Published: April 2016

AbstractStress and negative emotions pose a major threat to public health, by increasing the risk of obesity. Since the management process for emotions (emotion regulation; ER) is developed in childhood, we present a novel conceptual framework model for the role of ER in the prevention and treatment of childhood obesity. A narrative review of the literature by electronic database search (MEDLINE, Web of Knowledge and Scopus) was conducted of observational and interventional/experimental literature on ER and obesity and the underlying concepts. We also present an overview of ER intervention techniques. Our model indicates that childhood ER is a link between stress and obesity. Stress along with ineffective ER leads to abnormal cortisol patterns, emotional eating, sedentary lifestyle, reduction of physical activity, and sleep problems. Simultaneously, a healthy lifestyle could show benefits on ER and in developing adaptive ER strategies. In the development of obesity and ER, parents also play a role. By contrast, effective ER skills decrease obesity-related unhealthy behaviour and enhance protective factors, which boost health. The literature contains some observational studies of children but very few intervention studies, most of which are pilot or on-going studies. In conclusion, encouraging effective ER could be a useful new approach for combating and treating childhood obesity. Future ER intervention studies are needed to confirm the validity of this model in children.
Challenging Parties and Anti-Fascism in the Name of Democracy: The Fronte dell'Uomo Qualunque and its Impact on Italy's Republic
Authors: CORDUWENER PEPIJN 
Published: April 2016

AbstractThis article studies the political ideology of the Italian political movement Fronte dell'Uomo Qualunque in the light of the problems of party democracy in Italy. The movement existed only for a few years in the aftermath of the Second World War, but the impact of its ideology on post-war Italy was large. The article argues that the party's ideology should be studied beyond the anti-fascist–fascist divide and that it provides a window onto the contestation of party politics in republican Italy. It contextualises the movement in the political transition from fascism to republic and highlights key elements of the Front's ideology. The article then proceeds to demonstrate how the movement distinguished itself from the parties of the Italian resistance and advocated a radical break with the way in which the relationship between the Italian state and citizens had been practiced through subsequent regimes. The way in which the movement aimed to highlight the alleged similarities between the fascist and republican political order, and its own claim to democratic legitimacy, constitute a distinct political tradition which resurfaced in the political crisis of the 1990s.
AGREEMENT THEOREMS FOR SELF-LOCATING BELIEF
Authors: CAIE MICHAEL 
Published: April 2016

AbstractIn this paper, I first outline Aumann’s famous “no agreeing to disagree” theorem, and a second related theorem. These results show that if two or more agents, who have epistemic and credal states that are defined over algebras that do not include any self-locating propositions, have certain information about one another’s epistemic and credal states, then such agents must assign the same credence to certain propositions. I show, however, that both of these theorems fail when we consider agents who have epistemic and credal states that are defined over algebras that do include self-locating propositions. Importantly, these theorems fail for such agents even when we restrict our attention to the credences that such agents have in non-self-locating propositions. Having established this negative result, I then outline and prove three agreement theorems that hold for such agents.
The biological function of type I receptors of bone morphogenetic protein in bone
Authors: Lin Shuxian , Svoboda Kathy K H , Feng Jian Q , Jiang Xinquan 
Published: April 2016

AbstractBone morphogenetic proteins (BMPs) have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serine/threonine kinase receptors (BMPRI and BMPRII). In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2 (ALK2, also called type IA activin receptor), activin-like kinase 3 (ALK3, also called BMPRIA), and activin-like kinase 6 (ALK6, also called BMPRIB). The research areas covered include the current progress regarding the roles of these receptors during myogenesis, chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future.
Mitochondrial DNA plasticity is an essential inducer of tumorigenesis
Authors: Lee W T Y , Cain J E , Cuddihy A , Johnson J , Dickinson A , Yeung K-Y , Kumar B , Johns T G , Watkins D N , Spencer A , St John J C 
Published: April 2016

AbstractAlthough mitochondrial DNA has been implicated in diseases such as cancer, its role remains to be defined. Using three models of tumorigenesis, namely glioblastoma multiforme, multiple myeloma and osteosarcoma, we show that mitochondrial DNA plays defining roles at early and late tumour progression. Specifically, tumour cells partially or completely depleted of mitochondrial DNA either restored their mitochondrial DNA content or actively recruited mitochondrial DNA, which affected the rate of tumorigenesis. Nevertheless, non-depleted tumour cells modulated mitochondrial DNA copy number at early and late progression in a mitochondrial DNA genotype-specific manner. In glioblastoma multiforme and osteosarcoma, this was coupled with loss and gain of mitochondrial DNA variants. Changes in mitochondrial DNA genotype affected tumour morphology and gene expression patterns at early and late progression. Importantly, this identified a subset of genes that are essential to early progression. Consequently, mitochondrial DNA and commonly expressed early tumour-specific genes provide novel targets against tumorigenesis.
Genetic diversity affects ecological performance and stress response of marine diatom populations
Authors: Sjöqvist Conny O , Kremp Anke 
Published: April 2016

Abstract
Genetic diversity is considered an important factor, stabilizing ecological functions when organisms are faced with changing environmental conditions. Although well known from terrestrial systems, documentations of this relationship from marine organisms, and particularly planktonic microorganisms, are still limited. Here we experimentally tested the effects of genotypic diversity on ecologically relevant cellular parameters (growth, primary production, particulate organic carbon, particulate organic nitrogen, particulate organic phosphorus and biogenic silica) at optimal and suboptimal salinity conditions in a marine phytoplankton species. Multiple clonal genotyped and phenotypically characterized isolates of the diatom Skeletonema marinoi from the Baltic Sea were grown in monocultures and mixes of 5 and 20 clones at native (5 psu) and reduced (3 psu) salinities and respective parameters were compared. Re-genotyping of 30 individuals from each population at five microsatellite loci at the end of the experiment confirmed maintenance of genotypic richness. Although a diversity effect on growth was not detected, primary production and particulate organic nutrients were positively affected by increased diversity independent of salinity condition. Under salinity stress, highest values of primary production and particulate organic nitrogen content were measured at the high diversity level. The observed diversity effects emphasize the importance of genetic diversity of phytoplankton populations for ecological functions.
Disease dynamics and costly punishment can foster socially imposed monogamy
Authors: Bauch Chris T. , McElreath Richard 
Published: April 2016

AbstractSocially imposed monogamy in humans is an evolutionary puzzle because it requires costly punishment by those who impose the norm. Moreover, most societies were—and are—polygynous; yet many larger human societies transitioned from polygyny to socially imposed monogamy beginning with the advent of agriculture and larger residential groups. We use a simulation model to explore how interactions between group size, sexually transmitted infection (STI) dynamics and social norms can explain the timing and emergence of socially imposed monogamy. Polygyny dominates when groups are too small to sustain STIs. However, in larger groups, STIs become endemic (especially in concurrent polygynist networks) and have an impact on fertility, thereby mediating multilevel selection. Punishment of polygynists improves monogamist fitness within groups by reducing their STI exposure, and between groups by enabling punishing monogamist groups to outcompete polygynists. This suggests pathways for the emergence of socially imposed monogamy, and enriches our understanding of costly punishment evolution.
Diffractive imaging of a rotational wavepacket in nitrogen molecules with femtosecond megaelectronvolt electron pulses
Authors: Yang Jie , Guehr Markus , Vecchione Theodore , Robinson Matthew S. , Li Renkai , Hartmann Nick , Shen Xiaozhe , Coffee Ryan , Corbett Jeff , Fry Alan , Gaffney Kelly , Gorkhover Tais , Hast Carsten , Jobe Keith , Makasyuk Igor , Reid Alexander , Robinson Joseph , Vetter Sharon , Wang Fenglin , Weathersby Stephen , Yoneda Charles , Centurion Martin , Wang Xijie 
Published: April 2016

AbstractImaging changes in molecular geometries on their natural femtosecond timescale with sub-Angström spatial precision is one of the critical challenges in the chemical sciences, as the nuclear geometry changes determine the molecular reactivity. For photoexcited molecules, the nuclear dynamics determine the photoenergy conversion path and efficiency. Here we report a gas-phase electron diffraction experiment using megaelectronvolt (MeV) electrons, where we captured the rotational wavepacket dynamics of nonadiabatically laser-aligned nitrogen molecules. We achieved a combination of 100 fs root-mean-squared temporal resolution and sub-Angstrom (0.76 Å) spatial resolution that makes it possible to resolve the position of the nuclei within the molecule. In addition, the diffraction patterns reveal the angular distribution of the molecules, which changes from prolate (aligned) to oblate (anti-aligned) in 300 fs. Our results demonstrate a significant and promising step towards making atomically resolved movies of molecular reactions.
Parametric excitation and squeezing in a many-body spinor condensate
Authors: Hoang T. M. , Anquez M. , Robbins B. A. , Yang X. Y. , Land B. J. , Hamley C. D. , Chapman M. S. 
Published: April 2016

AbstractAtomic spins are usually manipulated using radio frequency or microwave fields to excite Rabi oscillations between different spin states. These are single-particle quantum control techniques that perform ideally with individual particles or non-interacting ensembles. In many-body systems, inter-particle interactions are unavoidable; however, interactions can be used to realize new control schemes unique to interacting systems. Here we demonstrate a many-body control scheme to coherently excite and control the quantum spin states of an atomic Bose gas that realizes parametric excitation of many-body collective spin states by time varying the relative strength of the Zeeman and spin-dependent collisional interaction energies at multiples of the natural frequency of the system. Although parametric excitation of a classical system is ineffective from the ground state, we show that in our experiment, parametric excitation from the quantum ground state leads to the generation of quantum squeezed states.
A general strategy for expanding polymerase function by droplet microfluidics
Authors: Larsen Andrew C. , Dunn Matthew R. , Hatch Andrew , Sau Sujay P. , Youngbull Cody , Chaput John C. 
Published: April 2016

AbstractPolymerases that synthesize artificial genetic polymers hold great promise for advancing future applications in synthetic biology. However, engineering natural polymerases to replicate unnatural genetic polymers is a challenging problem. Here we present droplet-based optical polymerase sorting (DrOPS) as a general strategy for expanding polymerase function that employs an optical sensor to monitor polymerase activity inside the microenvironment of a uniform synthetic compartment generated by microfluidics. We validated this approach by performing a complete cycle of encapsulation, sorting and recovery on a doped library and observed an enrichment of ∼1,200-fold for a model engineered polymerase. We then applied our method to evolve a manganese-independent α-L-threofuranosyl nucleic acid (TNA) polymerase that functions with >99% template-copying fidelity. Based on our findings, we suggest that DrOPS is a versatile tool that could be used to evolve any polymerase function, where optical detection can be achieved by Watson–Crick base pairing.