bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Significance of Markers of Endothelial Dysfunction in Case of Severe Combined Blunt Abdominal Trauma
Authors: Aleksandrov V. V. , Maskin S. S. , Ermolayeva N. K. , Perfilova V. N. , Matyukhin V. V. , Alimov M. N. , Biriulev D. S. , Rachid A. , Sigaev S. M. 
Published: October 2024

INTRODUCTION. In case of polytrauma, an imbalance occurs between substances produced by the endothelium, the rheological properties of the blood are disrupted, the content of procoagulants increases, the permeability of the vascular wall increases, which contributes to thrombus formation and increased tissue hypoxia, and subsequently to the development of multiple organ failure, and, of course, affects the course of traumatic disease, the development of complications and mortality. However, specific markers of endothelial dysfunction and their levels, by which it is possible to reliably predict the course of traumatic disease in severe combined closed abdominal trauma for the appropriate pathogenetic treatment have not yet been determined.AIM OF THE STUDY. To determine the significance of some markers of endothelial dysfunction (C-reactive protein, von Willebrand factor, the number of desquamated endothelial cells in the blood) in combined blunt abdominal trauma to predict the likelihood of complications and adverse outcomes.MATERIAL AND METHODS. The main group consisted of 31 patients with severe combined blunt abdominal trauma, the comparison group consisted of 5 patients operated on for large ventral hernias. All patients underwent blood tests for C-reactive protein, von Willebrand factor, the number of desquamated endothelial cells.RESULTS. The level of all three considered markers of endothelial dysfunction in severe abdominal trauma significantly differs from that in operated non-traumatized patients, which allows differential diagnostics to be made between abdominal wall contusion and damage to internal organs; extremely high values suggest an unfavorable course of traumatic disease and a high probability of a fatal outcome.CONCLUSION. Taking into account that the development of traumatic disease is based on damage to the vascular endothelium, it is necessary to consider as prognostic indicators changes in the level of activity of C-reactive protein, von Willebrand factor, desquamated endothelial cells in patients with severe combined blunt abdominal trauma.
Effectiveness of Adjunctive Drug Therapy to Endoscopic Stenting in Liver Cirrhosis Complicated by Refractory Variceal Bleeding
Authors: Anisimov A. Yu. , Anisimov Yu. A. 
Published: October 2024

AIM OF THE STUDY. Comparative clinical analysis of the efficacy of terlipressin and octreotide as additional drug therapy to mechanical hemostasis with nitinol stent in patients with liver cirrhosis complicated by bleeding from esophageal varices refractory to endoscopic treatment.MATERIAL AND METHODS. Thirty-one patients with liver cirrhosis complicated by esophageal variceal bleeding refractory to endoscopic treatment , in whose complex treatment program, as a first-line life­saving measure, hemostasis with a self-expanding hemostasis was performed nitinol stent were randomly assigned to two groups. In group A, 20 patients were treated with terlipressin as an adjuvant to mechanical hemostasis, and in group B, 11 patients were treated with octreotide. Unpaired Student’s t-test was used for statistical analysis of the results. Graphs for assessing the survival function of patients for 8 weeks after the end of treatment were constructed using the Kaplan-Meier method.RESULTS. In the acute observation period terlipressin and octreotide were equally effective in treating refractory variceal bleeding. In the subacute observation period, the administration of octreotide was generally accompanied by a greater number of side effects (54.5%) than terlipressin (30.0%) (p=0.453). In the remote observation period, 8-week survival in the group of patients receiving terlipressin was higher than in the group of patients receiving octreotide.CONCLUSION. Terlipressin is as effective as octreotide as an adjunct to endoscopic stenting in drug therapy for liver cirrhosis complicated by esophageal variceal bleeding refractory to endoscopic treatment. At the same time, terlipressin has a greater effect than octreotide on reducing 8-week mortality, which approaches statistical significance. In this regard, terlipressin may be the vasoactive drug of choice in acute refractory variceal bleeding.
Results of Carotid Endarterectomy Performed at Different Times During the Acute Period of Ischemic Stroke
Authors: Pryamikov A. D. , Loluev R. Yu. , Asratyan S. A. , Mironkov A. B. , Khripun A. I. 
Published: October 2024

AIM OF STUDY. To compare the results of carotid endarterectomy performed at different times (1st, 2nd and 3rd week) of the acute period of ischemic stroke.MATERIAL AND METHODS. In the acute period of ischemic stroke (1–21 days), 92 patients with symptomatic stenosis of the internal carotid artery of 50% or more were operated on using carotid endarterectomy . There were 66 men and 26 women. The average age was 65.7±8.4 years. All patients were divided into three groups depending on the timing of the operation: Group 1, where the operation was performed on the 1st week of stroke (n=48); Group 2, where the operation was performed on the 2nd week after stroke (n=28); Group 3, where carotid endarterectomy was performed on the 3rd week after stroke (n=16). In-hospital endpoints of the study in each group were ipsilateral ischemic stroke, any other stroke (contralateral ischemic or hemorrhagic), myocardial infarction, wound hemorrhagic complications requiring repeated operation and surgical hemostasis, death, and major adverse cardiovascular events (stroke + myocardial infarction + fatal outcome).RESULTS. There were no postoperative ipsilateral ischemic strokes, myocardial infarctions, or deaths in the study group (92 patients). In the overall group of patients (n = 92), the incidence of any postoperative stroke was 2.2% (2 patients): one hemorrhagic stroke on the side of carotid endarterectomy (group 3) and one contralateral ischemic stroke on the first postoperative day in a patient with bilateral critical stenosis of the internal carotid artery (group 1). Postoperative wound hematoma, which required revision and bleeding arrest in the early postoperative period, developed in one (1.1%) patient in Group 1. The overall incidence of major adverse cardiovascular events was 2.2% or 2 patients. In all three groups, a statistically significant and positive effect in regression of the initial neurological deficit was obtained at discharge. In patients operated in the first week after stroke, the neurological deficit at discharge according to the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin scale was the lowest. In general, 31.3%, 17.9% and 12.5% of patients in groups 1, 2 and 3 were discharged without neurological deficit (0 points according to the NIHSS scale), respectively.CONCLUSIONS. Carotid endarterectomy performed in the acute period of ischemic stroke is a safe surgical intervention in the prevention of recurrent ipsilateral ischemic events. The most positive neurological dynamics and the least neurological deficit at discharge were achieved after operations performed in the first week of ischemic stroke.
Creation and Preclinical Testing of a Spirometer with Extended Functionality
Authors: Shabaev V. S. , Onoshko V. A. , Galushko A. S. , Mazurok V. A. , Orazmagomedova I. V. , Vasilyeva L. G. , Aleksandrova D. A. 
Published: October 2024

RELEVANCE. We present the results of preclinical testing of an upgraded portable AR­1 gas flow analyzer produced by JSC Krasnogvardeets (Saint Petersburg) in order to create import-substituting technologies and develop practical and scientific spheres of healthcare.THE AIM OF THE STUDY. was to substantiate the possibility of clinical use of the upgraded device, originally intended for testing ventilators and inhalation anesthesia devices, as a monitor of the external respiration apparatus function.MATERIAL AND METHODS. The preclinical study of the upgraded gas flow analyzer was conducted at the V.A. Almazov National Medical Research Center in comparison with devices for conventional (Bellavista 950, Berner Ross Medical, Russia) and high-frequency (IPV-2C, Intrapulmonary Percussive Ventilation, Percussionaire Corporation, USA) mechanical ventilation in volume- and pressure-controlled modes using an artificial lung. The following reflected spirometry parameters were compared: tidal and minute volume under inhalation and exhalation, respiratory rate, maximum and minimum flows, peak and positive end expiratory pressure, fraction of inspired oxygen.RESULTS. A high accuracy of parameter matching shown by the gas flow analyzer and ventilators was demonstrated.CONCLUSION. The upgraded model of the gas flow analyzer can be used clinically as a portable spirometer at the prehospital and hospital stages.
EFEKTIVITAS METODE SHOW AND TELL TERHADAP KEMAMPUAN BERBICARA SERTA SOSIAL EMOSIONALSISWA KELAS IV
Authors: Musarofah Isnaeni , Iswara Prana Dwija , Djuanda Dadan 
Published: October 2024

Speaking skills are an essential component of school learning that needs to be learned. In the same way, to support learning activities, students need to develop their social emotional skills. But in reality, some students still have a tough time in speaking also not able to manage their social emotional skills. This study aims to see the effectiveness of show and tell method in speaking also social emotiona skillsl. The method used was experiments with a pre-experimental research design, also used one-shot case study, one sample t-test to test the achievability of learning with minimum completion criteria and independent sample t-test to evaluate a different in speaking skills of male and female students. Fourth grade students in Bandung Regency were the subjects of this study. Based on the results of the study, the average score of students' practical speaking skills was 84.1 seen from the assessment indicators. Show and tell method was effectively used with variations in students' performance.
Pengaruh Daya dan Kecepatan Mesin Laser Engraving Portable terhadap Hasil Ukir Kayu
Authors: Finali Asmar 
Published: October 2024

Kegiatan industri yang berkembang pesat meningkatkan kebutuhan akan kayu di Indonesia, yang sebelumnya terbatas pada pemanfaatan kayu bulat dari hutan tanaman. Potensi pohon durian dalam hutan rakyat diproyeksikan meningkat seiring dengan tingginya permintaan masyarakat terhadap buah durian. Selain itu, limbah kayu jati belanda dapat dimanfaatkan sebagai bahan kerajinan industri. Teknologi terbarukan seperti laser engraving dapat memaksimalkan potensi ini.Penelitian ini menguji pengukiran kayu durian dan kayu jati Belanda menggunakan mesin laser engraving portable. Setiap spesimen berukuran 70 mm x 70 mm dengan ketebalan 4 mm, dan diukir dengan pola lingkaran berdiameter 20 mm. Tujuan penelitian ini adalah untuk mengoptimalkan penggunaan mesin laser engraving, mencapai hasil ukiran yang efisien, serta memahami pengaruh daya dan kecepatan mesin terhadap material yang berbeda. Hasil pengujian menunjukkan bahwa akurasi tertinggi pada kayu jati Belanda dicapai dengan daya 95%(2,85 watt) dan kecepatan 90%(4,12cm/m), serta daya 100%(3,00 watt) dan kecepatan 95%(4,50cm/m). Untuk kayu durian, akurasi tertinggi dicapai dengan daya 95% (2,85 watt) dan kecepatan 100%(4,71cm/m). Variasi kecepatan 90%(4,12cm/m) hingga 100%(4,71cm/m) dengan daya 95%(2,85 watt) menghasilkan ukiran yang presisi dan akurat pada kedua jenis kayu. Berdasarkan hasil pengujian, kecepatan optimum untuk kayu jati Belanda adalah 90%(4,12cm/m) dengan rata-rata akurasi 99,8%. Sedangkan untuk kayu durian, kecepatan optimum adalah 100%(4,71cm/m) dengan rata-rata akurasi 99,3%. Dari kedua jenis kayu tersebut, kayu jati Belanda menunjukkan akurasi yang lebih tinggi dibandingkan dengan kayu durian. Penelitian ini diharapkan dapat mengoptimalkan penggunaan mesin laser engraving dan mencapai hasil ukiran yang diinginkan dengan efisien pada berbagai jenis kayu.
Medical-grade honey has superior antibacterial properties against common bacterial isolates in wound cultures of dogs and cats in comparison to non–medical-grade honey types
Authors: Neo Roxanna , Gaonkar Pankaj , Huber Laura , Hlusko Katelyn C. 
Published: October 2024

Abstract

OBJECTIVE
To compare the antibacterial activities of different types of honey against common bacterial isolates cultured from wounds of dogs and cats.

METHODS
4 types of honey were used including a medical-grade manuka honey, a non–medical-grade manuka honey, a locally sourced non–medical-grade honey (non-MGH), and a commercially sourced non-MGH. Bacterial isolates were obtained from clinical wound cultures of dogs and cats including Staphylococcus pseudintermedius, Escherichia coli, Enterococcus faecalis, and Pseudomonas aeruginosa. The macro-broth dilution method was used to analyze the MIC and minimum bactericidal concentration. The percentage of growth inhibition was assessed for different types of honey at different concentrations using a generalized linear regression model.

RESULTS
Medical-grade honey exhibited the lowest minimum bactericidal concentration against S pseudintermedius, E faecalis, and P aeruginosa, alongside the lowest MIC at 90% with statistically significant higher bacterial growth inhibition in medium and low concentrations. Non–medical-grade manuka honey had a similar bactericidal activity against S pseudintermedius and P aeruginosa compared to locally and commercially sourced non-MGH.

CONCLUSIONS
In this in vitro study, MGH exhibited superior antibacterial activity against all bacterial isolates compared to other types of honey.

CLINICAL RELEVANCE
Medical-grade honey displayed the greatest antibacterial activity against common wound pathogens and could be considered over other types of honey for wound management in cats and dogs. Locally and commercially sourced non-MGH appears to have a comparative efficacy against certain bacteria compared to non–medical-grade manuka honey and is more cost effective. Further in vivo studies are needed to confirm these findings.
Innovation as a Foundation of Competitiveness of Smes on the Colombo-Venezuelan Frontier
Authors: Rodríguez-Márquez Ritssy Liney , Bracho-Navarro Isaac Enrrique , Angulo-Rangel Franklin Alejandro 
Published: October 2024

Objective: This article is the result of a research carried out in a group of SMEs with the objective of analyzing innovation in this business commercial segment. Innovation has become a determining factor for the success of modern organizations due to their ability to generate products and services that satisfy customer needs.

Theoretical Framework: Several authors with extensive research experience were consulted in order to add a theoretical construct to the research regarding innovation in organizations.

Method: The methodology adopted for this research was executed under a quantitative, descriptive and analytical approach, with a field, non-experimental and transactional design. The information was obtained directly with the application of a structured instrument to an intentional sample applied to ten managers of SMEs on the Colombian-Venezuelan frontier.

Results and Discussion: It was established that these do not receive adequate attention from management since all the evaluated indicators were located at a medium and low level in an instrument designed with a Likert scale.

Research Implications: It can be inferred that the managers in question do not make significant implementations or changes in the products or services they market, failing to generate economic value due to the non-implementation of strategies that lead to an increase in operational income within the managed organizations.

Originality/Value: The research carried out under the positivist paradigm due to its quantitative approach based on the rigorous application of the scientific method, is characterized by the possibility of generalization, which allows based on particular results to proceed to make generalizations that can be applied in similar circumstances.
Counter Home: Unravelling the Socio-Spatial Dynamics of Hijra Dwellings of Khulna, Bangladesh
Authors: Podder Apurba K. , Shahidullah Fadia Binte 
Published: October 2024

Amidst limited social acceptance and scant governmental and non-governmental support for third gender communities in Bangladesh, this paper explores the intricate relationship between the conception of hijra and its profound impact on redefining the notion of home. In the queer tropics, hijra communities form a unique identity within South Asia’s urban fabric. Employing ethnographic methods and spatial analysis, this multidisciplinary study investigates the hijra home-making process in Khulna, Bangladesh, shedding light on their lived experiences. It unravels the complex interplay of tropical architecture leading to their transformation into, and stigmatisation as, hijras, investigating the spatial implications of their stigma in the organisation of household spaces based on hijra notions of publicness-privateness, spatial sequencing/order, layering, and hierarchy. The formal articulation of homes and their integration into the larger urban scale signifies a distinctive counter-spatial culture within this marginalised community, which acts to counter prevailing ideas of stability, ownership, and family within the concept of home. This counter-culture, as the paper unveils, makes the hijra home dynamics a process of socio-spatial transaction where gender identities manifest and are subverted/shaped by the domestic space. The findings of the paper enrich our understanding of the diverse spatial ways social discriminations are interwoven into the ordinary fabric of contemporary urban living in the tropical city of Khulna.
Association of IL 6 rs1800795 genetic variation with the susceptibility and severity of COVID-19: A meta-analysis
Authors: Ivanova E.S. , Eid M.A. , Shkurat T.P. 
Published: October 2024

Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease, which caused a global pandemic. The differences of symptoms among COVID-19 patients made it important to search for the factors that may play a significant role in its pathogenesis. The aim of the current study was to investigate the association of interleukin 6 (IL-6) genetic variation rs1800795 with both susceptibility and severity of COVID-19, by performing a meta-analysis of the available data in the literature. Several databases were searched using specific keywords, and a total of 12 full-text articles were included in the analysis. No association was found with the COVID-19 susceptibility. However, a significant association was found between the studied polymorphism and the COVID-19 severity in the recessive model of inheritance (OR =2.11, 95% CI [1.12, 3.98], p=0.02). To our knowledge, this meta-analysis is the first to study the association of IL6 rs1800795 with both susceptibility and severity of COVID-19, and its results reflect the current published data, and may serve as a guide for further research.
Коронавирусная инфекция 2019 года (COVID-19) является высококонтагиозным инфекционным заболеванием, вызвавшим глобальную пандемию. Различия в симптомах у пациентов с COVID-19 сделали важным поиск факторов, которые могут играть значительную роль в ее патогенезе. Целью настоящего исследования было изучение связи генетической вариации интерлейкина 6 (IL-6) rs1800795 как с восприимчивостью, так и с тяжестью заболевания COVID-19 путем проведения метаанализа имеющихся в литературе данных. Был проведен поиск по нескольким базам данных с использованием определенных ключевых слов, и в общей сложности в анализ были включены 12 полнотекстовых статей. Не было обнаружено никакой связи rs1800795 в гене IL 6 с восприимчивостью к COVID-19. Однако была обнаружена значимая связь между изучаемым полиморфизмом и тяжестью COVID-19 при рецессивной модели наследования (OR =2,11, 95% CI [1,12; 3,98], р=0,02). Насколько нам известно, этот мета-анализ является первым, в котором изучается связь IL6 rs1800795 как с восприимчивостью, так и с тяжестью заболевания.
Древнеримское гражданство: идеал и реальность
Authors: Львов А.В. 
Published: October 2024

В статье рассматриваются вопросы, связанные с римским гражданством, элементами идеального представления о нем и его ценностях и принципах, проблемами их реализации, эволюции и упадка.
The article deals with issues related to Roman citizenship, elements of an ideal idea about it and its values and principles, problems of their realization, evolution and decline.
Генезис понятия криминалистической характеристики механизма преступления
Authors: Чурилов С.Н. 
Published: October 2024

В статье рассматриваются вопросы зарождения, становления и современного состояния понятия криминалистической характеристики механизма преступления. Излагается авторское видение структуры этого понятия, его соотношения с обстоятельствами, подлежащими доказыванию при расследовании преступлений конкретного вида, а также перспективы развития.
The article deals with the origin, formation and current state of the concept of forensic characterization of the crime mechanism. It considers the author’s vision of the structure of this concept, its correlation with the circumstances to be proved when investigating crimes of a particular type, as well as the development prospects.
Клуб как пространство сопричастного управления горожан своим образованием в контексте социально-экономических и социокультурных преобразований города
Authors: Ле-ван Т Н. , Алексейчева Е.Ю. , Нехорошева Е.В. 
Published: October 2024

В статье ставится проблема возможностей управления граждан непрерывным самообразованием. Одним из решений авторы видят создание в мегаполисе единого клубного пространства, где каждый сможет реализовать в реальном или цифровом режиме витальную потребность в образовании и развивающей коммуникации. В связи с этим обсуждаются организационно-управленческие и технологические решения, в рамках которых горожанин будет учиться управлять своими образовательными потребностями и их реализацией в течение всей жизни.
The article poses the problem of possibilities for citizens’ management of their continuous self-education. One of the solutions is the creation of a united club space in the metropolis, where everyone in real or digital mode can fulfill the vital need for learning and developing communication. In this regard, organizational, managerial and technological solutions are discussed, within which a city dweller will learn to manage his educational needs and their implementation throughout his life.
Культура в системе современной лингводидактической концептологии
Authors: Тарева Е.Г. 
Published: October 2024

В статье рассматривается динамика аксиосферы лингводидактики как науки, методологические основания которой находятся в состоянии кардинального пере- смотра под воздействием объективных факторов и смены научной парадигматики. Делается акцент на последовательном переосмыслении феномена «культура» и смене его статуса в структуре лингводидактической концептологии. Выделяются внешние и внутренние обстоятельства, под влиянием которых происходит изменение научных доминант, связанных со сменой образовательных парадигм.
The article discusses the dynamics of the axiosphere of linguodidactics, methodological foundations of which are cardinally changed under the influence of objective factors and shifts in scientific paradigmatics. The most significant is the consistent rethinking of the phenomenon of «culture» and the change of its status in the structure of linguodidactic conceptology. It is shown under the influence of which external and internal factors there is a change in scientific dominants due to the changes of educational paradigms.