bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying differentially coexpressed module during HIV disease progression: A multiobjective approach
Authors: Ray Sumanta , Maulik Ujjwal 
Published: March 2017

AbstractMicroarray analysis based on gene coexpression is widely used to investigate the coregulation pattern of a group (or cluster) of genes in a specific phenotype condition. Recent approaches go one step beyond and look for differential coexpression pattern, wherein there exists a significant difference in coexpression pattern between two phenotype conditions. These changes of coexpression patterns generally arise due to significant change in regulatory mechanism across different conditions governed by natural progression of diseases. Here we develop a novel multiobjective framework DiffCoMO, to identify differentially coexpressed modules that capture altered coexpression in gene modules across different stages of HIV-1 progression. The objectives are built to emphasize the distance between coexpression pattern of two phenotype stages. The proposed method is assessed by comparing with some state-of-the-art techniques. We show that DiffCoMO outperforms the state-of-the-art for detecting differential coexpressed modules. Moreover, we have compared the performance of all the methods using simulated data. The biological significance of the discovered modules is also investigated using GO and pathway enrichment analysis. Additionally, miRNA enrichment analysis is carried out to identify TF to miRNA and miRNA to TF connections. The gene modules discovered by DiffCoMO manifest regulation by miRNA-28, miRNA-29 and miRNA-125 families.
Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
Authors: Pascart Tristan , Falgayrac Guillaume , Migaud Henri , Quinchon Jean-François , Norberciak Laurène , Budzik Jean-François , Paccou Julien , Cotten Anne , Penel Guillaume , Cortet Bernard 
Published: March 2017

AbstractNon-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in the collapse is suspected, the underlying modifications induced at a molecular level have not been explored in humans. Here, we examine changes in the molecular composition and structure of bone as evaluated by Raman spectroscopy in human end-stage ON. Comparing samples from femoral heads harvested from 11 patients and 11 cadaveric controls, we show that the mineral and organic chemical composition of trabecular bone in ON is not modified apart from age-related differences. We also show that the molecular composition in the necrotic part of the femoral head is not different from the composition of the remaining ‘healthy’ trabecular bone of the femoral head. These findings support that quality of trabecular bone is not modified during ON despite extensive bone marrow necrosis and osteocyte death observed even in the ‘healthy’ zones on histological examination.
High quality transparent conductive Ag-based barium stannate multilayer flexible thin films
Authors: Wu Muying , Yu Shihui , He Lin , Yang Lei , Zhang Weifeng 
Published: March 2017

AbstractTransparent conductive multilayer thin films of silver (Ag)-embedded barium stannate (BaSnO3) structures have been deposited onto flexible polycarbonate substrates by magnetron sputtering at room temperature to develop an indium free transparent flexible electrode. The effect of thicknesses of Ag mid-layer and barium stannate layers on optical and electrical properties were investigated, and the mechanisms of conduction and transmittance were discussed. The highest value of figure of merit is 25.5 × 10−3 Ω−1 for the BaSnO3/Ag/BaSnO3 multilayer flexible thin films with 9 nm thick silver mid-layer and 50 nm thick barium stannate layers, while the average optical transmittance in the visible range from 380 to 780 nm is above 87%, the resistivity is 9.66 × 10−5 Ω · cm, and the sheet resistance is 9.89 Ω/sq. The change rate of resistivity is under 10% after repeated bending of the multilayer flexible thin films. These results indicate that Ag-based barium stannate multilayer flexible thin films can be used as transparent flexible electrodes in various flexible optoelectronic devices.
Structural Phase Transition of ThC Under High Pressure
Authors: Yu Cun , Lin Jun , Huai Ping , Guo Yongliang , Ke Xuezhi , Yu Xiaohe , Yang Ke , Li Nana , Yang Wenge , Sun Baoxing , Xie Ruobing , Xu Hongjie 
Published: March 2017

AbstractThorium monocarbide (ThC) as a potential fuel for next generation nuclear reactor has been subjected to its structural stability investigation under high pressure, and so far no one reported the observation of structure phase transition induced by pressure. Here, utilizing the synchrotron X-ray diffraction technique, we for the first time, experimentally revealed the phase transition of ThC from B1 to P4/nmm at pressure of ~58 GPa at ambient temperature. A volume collapse of 10.2% was estimated during the phase transition. A modulus of 147 GPa for ThC at ambient pressure was obtained and the stoichiometry was attributed to the discrepancy of this value to the previous reports.
Patient Self-Assessed Passive Range of Motion of the Knee Cannot Replace Health Professional Measurements
Authors: Madsen Frank , Odgaard Anders , Borgbjerg Jens 
Published: March 2017

AbstractThe purpose of this study was to investigate whether patients can accurately self-assess their knee passive range of motion (PROM). A picture-based questionnaire for patient self-assessment of knee PROM was developed and posted to patients. The self-assessed PROM from 58 patients was compared with surgeon-assessed PROM using a short-arm goniometer. Agreement between the measurement methods was calculated with the Bland-Altman method. We calculated the sensitivity and specificity of patient-assessed PROM in dichotomously detecting knee motion impairment in both flexion (≤ 100 degrees) and extension (≥ 10-degree flexion contracture). Surgeon- and patient-assessed knee PROM showed a mean difference (95% limits of agreement) of −2.1 degrees (−42.5 to 38.3 degrees) for flexion and −8.1 degrees (−28.8 to 12.7 degrees) for extension. The sensitivity of patient self-assessed PROM in identifying knee flexion and extension impairments was 86 and 100%, respectively, whereas its specificity was 84 and 43%, respectively. Although wide limits of agreement were observed between surgeon- and patient-assessed knee PROM, the picture-based questionnaire for patient assessment of knee ROM was found to be a valid tool for dichotomously detecting knee motion impairment in flexion (≤ 100 degrees). However, the specificity of the questionnaire for detection of knee extension impairments (≥ 10-degree flexion contracture) was low, which limits is practical utility for this purpose.
Comparison of coronary artery calcification, carotid intima-media thickness and ankle-brachial index for predicting 10-year incident cardiovascular events in the general population
Authors: Geisel Marie Henrike , Bauer Marcus , Hennig Frauke , Hoffmann Barbara , Lehmann Nils , Möhlenkamp Stefan , Kröger Knut , Kara Kaffer , Müller Tobias , Moebus Susanne , Erbel Raimund , Scherag André , Jöckel Karl-Heinz , Mahabadi Amir A. ,   on behalf of the investigative group of the Heinz Nixdorf Recall study
Published: March 2017

Aims
To compare the predictive value of coronary artery calcification (CAC), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) in a primary prevention cohort depending on risk factor profile to determine which of the three markers improves cardiovascular (CV) risk discrimination best in which risk group.

Methods and Results
We quantified CAC, CIMT, and ABI in 3108 subjects (mean age 59.2 ± 7.7, 47.1% male) without prevalent CV diseases from the population-based Heinz Nixdorf Recall study. Associations with incident major CV events (coronary event, stroke, CV death; n = 223) were assessed during a follow-up period of 10.3 ± 2.8 years with Cox proportional regressions in the total cohort and stratified by Framingham risk score (FRS) groups. Discrimination ability was evaluated with Harrell’s C. All three markers were associated with CV events (hazard ratio [95% confidence interval (CI)]: CAC: 1.31 (1.23–1.39) per 1-unit increase in log(CAC + 1) vs. CIMT: 1.27 (1.13–1.43) per 1 SD vs. ABI: 1.30 (1.14–1.49) per 1 SD, in FRS adjusted models). Considering reclassification, CAC lead to highest reclassification in the total cohort, while also for CIMT and ABI significant improvement in net-reclassification was observed [NRI (95% CI): CAC: 0.55 (0.42–0.69); CIMT: 0.32 (0.19–0.45); ABI: 0.19 (0.10–0.28)].

Conclusion
Coronary artery calcification provides the best discrimination of risk compared with CIMT and ABI, particularly in the intermediate risk group, whereas CIMT may be an alternative measure for reassurance in the low risk group.
Do health information technology self-management interventions improve glycemic control in medically underserved adults with diabetes? A systematic review and meta-analysis
Authors: Heitkemper Elizabeth M , Mamykina Lena , Travers Jasmine , Smaldone Arlene 
Published: March 2017

AbstractObjective: The purpose of this systematic review and meta-analysis was to examine the effect of health information technology (HIT) diabetes self-management education (DSME) interventions on glycemic control in medically underserved patients.Materials and Methods: Following an a priori protocol, 5 databases were searched. Studies were appraised for quality using the Cochrane Risk of Bias assessment. Studies reporting either hemoglobin A1c pre- and post-intervention or its change at 6 or 12 months were eligible for inclusion in the meta-analysis using random effects models.Results: Thirteen studies met the criteria for the systematic review and 10 for the meta-analysis and represent data from 3257 adults with diabetes (mean age 55 years; 66% female; 74% racial/ethnic minorities). Most studies (n = 10) reflected an unclear risk of bias. Interventions varied by HIT type: computer software without Internet (n = 2), cellular/automated telephone (n = 4), Internet-based (n = 4), and telemedicine/telehealth (n = 3). Pooled A1c decreases were found at 6 months (−0.36 (95% CI, −0.53 and −0.19]; I2 = 35.1%, Q = 5.0), with diminishing effect at 12 months (−0.27 [95% CI, −0.49 and −0.04]; I2 = 42.4%, Q = 10.4).Discussion: Findings suggest that medically underserved patients with diabetes achieve glycemic benefit following HIT DSME interventions, with dissipating but significant effects at 12 months. Telemedicine/telehealth interventions were the most successful HIT type because they incorporated interaction with educators similar to in-person DSME.Conclusion: These results are similar to in-person DSME in medically underserved patients, showing that well-designed HIT DSME has the potential to increase access and improve outcomes for this vulnerable group.
The Infrazygomatic Segment of the Superficial Temporal Artery: Anatomy and Technique for Harvesting a Better Interposition Graft
Authors: Meybodi Ali Tayebi , Lawton Michael T. , El-Sayed Ivan , Davies Jason , Tabani Halima , Feng Xuequan , Benet Arnau 
Published: March 2017

Abstract

BACKGROUND: The superficial temporal artery (STA) is underutilized as an interposition graft because current techniques expose and harvest STA above the level of the zygoma. This technique yields a diminutive arterial segment in both length and diameter, which limits its use for extracranial−intracranial bypass.

OBJECTIVE: To introduce a safe and efficient technique for harvesting of the infrazygomatic segment of the STA.

METHODS: Scalp layers, STA, and the facial nerve were studied in 18 specimens. The length of the STA segment harvested below the superior border of the zygomatic arch was measured. Safety of this technique was assessed by measuring the distance between the facial nerve and the STA.

RESULTS: The galea and subgaleal fat pad were the only anatomical planes found between the facial nerve and the STA below the zygomatic arch. A dense subcutaneous band of galea contained the STA and allowed proximal dissection of the artery without exposing the facial nerve. The average length of the artery harvested between the zygomatic arch and the parotid gland was 20 mm.

CONCLUSION: Subcutaneous dissection within the galea below the level of the zygomatic arch and preservation of the dense subcutaneous band surrounding the STA avoids transecting the facial nerve branches while providing increased STA exposure. This anatomical knowledge may increase the use of STA as an interposition graft in cerebrovascular bypass procedures and reduce the need to harvest grafts through additional incisions at remote sites.
Performance of the Patient-Reported Outcomes Measurement Information System-29 in scleroderma: a Scleroderma Patient-centered Intervention Network Cohort Study
Authors: Kwakkenbos Linda , Thombs Brett D. , Khanna Dinesh , Carrier Marie-Eve , Baron Murray , Furst Daniel E. , Gottesman Karen , van den Hoogen Frank , Malcarne Vanessa L. , Mayes Maureen D. , Mouthon Luc , Nielson Warren R. , Poiraudeau Serge , Riggs Robert , Sauvé Maureen , Wigley Fredrick , Hudson Marie , Bartlett Susan J. ,   on behalf of the SPIN Investigators
Published: March 2017

Abstract
Objective. The Patient-Reported Outcomes Measurement Information System (PROMIS)-29 assesses seven health-related quality of life domains plus pain intensity. The objective was to examine PROMIS-29v2 validity and explore clinical associations in patients with SSc.
Methods. English-speaking SSc patients in the Scleroderma Patient-centered Intervention Network Cohort from 26 sites in Canada, the USA and the UK completed the PROMIS-29v2 between July 2014 and November 2015. Enrolling physicians provided medical data. To examine convergent validity, hypotheses on the direction and magnitude of correlations with legacy measures were tested. For clinical associations, t-tests were conducted for dichotomous variables and PROMIS-29v2 domain scores. Effect sizes (ESs) were labelled as small (&lt;0.25), small to moderate (0.25–0.45), moderate (0.46–0.55), moderate to large (0.56–0.75) and large (&gt;0.75).
Results. There were 696 patients (87% female), mean (s.d.) disease duration 11.6 (8.7) years, 57% with limited cutaneous subtype. Validity indices were consistent with seven of nine hypotheses (|r| =0.51–0.87, P &lt; 0.001), with minor divergence for two hypotheses. Gastrointestinal involvement was associated with significantly worse outcomes for all eight PROMIS-29v2 domains (moderate or moderate to large ES in six of eight). Presence of joint contractures was associated with significant decrements in seven domains (small or small to moderate ESs). Skin thickening, diffuse cutaneous subtype and presence of overlap syndromes were significantly associated (small or small to moderate ESs) with five or six domains.
Conclusion. This study further establishes the validity of the PROMIS-29v2 in SSc and underlines the importance of gastrointestinal symptoms and joint contractures in reduced health-related quality of life.
Renal cell carcinoma: molecular characterization and evolving treatment paradigms
Authors: Ball Mark W. , Singer Eric A. , Srinivasan Ramaprasad 
Published: March 2017

Purpose of review
The treatment landscape of advanced renal cell carcinoma (RCC) continues to shift as both new targeted therapies and immunotherapies show efficacy in treating the disease. Contemporary insights into the molecular characterization of RCC are likely to fuel the development of additional therapies. This review summarizes recent advancements in the biologic characterization of RCC and discusses newly approved therapies and ongoing studies in the treatment of advanced RCC.

Recent findings
The Cancer Genome Atlas has now completed comprehensive molecular characterization of clear cell, papillary, and chromophobe RCC, providing insights into the biology of these entities. Two new ‘targeted’ therapies, cabozantinib and lenvatinib, as well as a novel immune checkpoint inhibitor, the programed death 1 inhibitor nivolumab, have recently been approved for the treatment of metastatic RCC. Although some of these newer therapies are associated with prolongation of survival, there are few long-term responders and the quest for more durable treatment strategies continues.

Summary
The addition of several new agents effective in metastatic RCC has resulted in improvements in overall survival; however, there are few avenues to durable responses or cure. Ongoing studies as well advances in our understanding of the molecular alterations underlying distinct forms of RCC promise further therapeutic advances and have the potential to alter the current treatment paradigm.
New Classification System for Tear Trough Deformity
Authors: Turkmani Mohammed G. 
Published: March 2017

BACKGROUND
Tear trough deformities (TTD) refer to a set of conditions leading to different shapes in the junction between the lower eyelid and the cheek. Tear trough deformity is a major aesthetic concern for a lot of individuals seeking periorbital rejuvenation and is one of the most discussed landmarks in facial aesthetic surgery.

OBJECTIVE
To describe a new morphologically related classification system, providing an objective means to evaluating the deformity.

METHODS
The article proposes a new classification system exhibiting 5 different forms of a TTD based on the author's clinical experience and review of medical literature.

CONCLUSION
Five forms of a TTD include a “hill” due to the superficial infraorbital fat pad herniation; a “valley” caused by fat reduction and skin changes; a “hill-valley” resulting from the weakening of the orbital portion of the orbicularis oculi muscle and its retaining ligaments, followed by fat reduction and skin changes; a “hill-valley-hill-valley” formed by a series of changes in portions of the orbicularis oculi muscle and its retaining ligaments; and a “mixed” form depicting a range of any of the 4 deformities. Classification of TTD is of great value to aid the treating physician in choosing the appropriate treating options.
RISK OF SILICONE OIL AS VITREOUS TAMPONADE IN PARS PLANA VITRECTOMY
Authors: Feng XiaoXiao , Li Cheng , Zheng Qishan , Qian XiaoBin g , Shao WanWen , Li YuJie , Li Wei , Yin Lu , Wang Yang , Gao QianYing 
Published: March 2017

Purpose:
The authors examined the differences between silicone oil and other vitreous tamponades or placebo in performing pars plana vitrectomy.

Methods:
This review and meta-analysis was conducted in accordance with the PRISMA guidelines. Seven databases and the reference lists of the retrieved randomized controlled trial articles were searched to identify eligible studies. The primary outcomes were the rate of redetachment after endotamponade removal, the rate of reoperation, and poor visual acuity. The secondary outcomes were adverse events and quality of life related to postoperative position.

Results:
Ten articles (12 trials) were included. There were no significant differences between silicone oil and other agents in most of the primary and second outcomes. Only the risk of hypotony was found to be significantly lower when filling with silicone oil, compared with other agents. No trial reported the quality of life related to postoperative position.

Conclusion:
Based on the available studies, the authors conclude that there is no significant difference in the risk of poor outcomes between pars plana vitrectomy with silicone oil and that with other vitreous tamponades with different surgical histories.
RESOLUTION OF FOVEAL CYST AFTER THE RELEASE OF VITREOMACULAR ATTACHMENT IN EYE WITH MACULAR TELANGIECTASIA TYPE 2
Authors: Kimura Machiko , Koizumi Hideki , Maruko Ichiro , Iida Tomohiro 
Published: March 2017

Purpose:
To report a case of macular telangiectasia Type 2 that showed a resolution of a foveal cystic change accompanying the release of vitreomacular attachment.

Methods:
Retrospective chart review.

Report of the case:
A 75-year-old man presented with a bilateral decrease in visual acuity and metamorphopsia. At the initial visit, the left eye demonstrated a hyporeflective foveal cyst and a perifoveal vitreous detachment on optical coherence tomography. The characteristic clinical findings were consistent with the diagnosis of macular telangiectasia Type 2. Fifteen months later, the patient returned with a remission of the metamorphopsia in the left eye. The left eye had a vitreous detachment from the macula, and the hyporeflective foveal cyst was completely resolved.

Conclusion:
At least in some cases, vitreous traction or attachment may play a role in the morphologic changes seen in macular telangiectasia Type 2.
Oral Healthcare and Cardiovascular Disease
Authors: Sanchez Paula , Everett Bronwyn , Salamonson Yenna , Ajwani Shilpi , George Ajesh 
Published: March 2017

Background:
There is epidemiological evidence showing an association between periodontal disease and cardiovascular disease (CVD). Despite this evidence* no comprehensive review has been undertaken to identify strategies to improve the oral health of people with CVD.

Objectives:
The aim of this review is to identify current evidence relating to the oral healthcare and management of patients with CVD.

Methods:
A scoping review was undertaken focusing on 4 key areas, namely, the impact of periodontal treatment on CVD, current recommendations regarding oral health and CVD, the role of nurses in promoting oral health, and available resources to support them. Databases were searched using a combination of keywords and search terms and 34 articles were selected.

Results:
Systematic reviews suggest that periodontal treatment may improve CVD outcomes by reducing systemic inflammation and improving endothelial function. However, there is insufficient evidence to confirm or refute these findings. International guidelines recognize the link between periodontal disease and CVD and recommend preventative strategies in this area. Non–oral health professionals, including nurses, can promote oral health and have been undertaking this role in areas like aged care and pregnancy. However, this aspect of nursing care has not been explored in the cardiac setting and no relevant training and assessment tools are available.

Conclusions:
Maintaining oral health among cardiovascular patients is important, yet it appears to be neglected during cardiac care. Cardiac nurses are in an excellent position to promote oral health but further research is required to define their role and develop supporting resources.