bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teatro e romance em José de Alencar: As asas de um anjo e Lucíola
Authors: Caixeta Nascentes Zama 
Published: December 2015

<p>Defenderemos a hipótese de que no romance <em>Lucíola</em> Alencar acatou os motivos alegados, em 1858, para a proibição de <em>As Asas de um Anjo</em>. O interdito ancorava-se no argumento de ser imoral a comédia, em especial as cenas do rapto de Carolina por Ribeiro e do encontro quase incestuoso dela com o pai. A atitude de Alencar foi de defender a obra e publicá-la no ano seguinte, sem nenhum corte. Em 1862, lançou <em>Lucíola</em>, retomando o mesmo assunto da peça. No romance, não há rapto de Lúcia e nem aproximação licenciosa entre pai e filha cortesã; com freqüência, o que lemos são justificativas da moralidade da narrativa. Tudo isso sugere a incorporação, ainda que tardiamente, das críticas outrora endereçadas a <em>As Asas de um Anjo</em>.</p>
Ecologia, educação e utopia: Wilson Rocha e a literatura infanto-juvenil na década de 80
Authors: Rosevics Larissa 
Published: December 2015

<p>O presente artigo procura analisar as dimensões utópicas existentes nos livros <em>O Filho das Estrelas (1989) </em>e <em>Os passageiros do futuro (1987)</em> de Wilson Rocha e suas relações com a discussão global sobre ecologia na década de 1980. Entendendo ser a educação o melhor meio para desenvolver nas crianças e jovens a consciência ecológica, procurou-se demonstrar como, através da literatura infanto-juvenil, o autor transmite uma preocupação ambiental local e global. Apesar dos livros de Wilson Rocha não serem utopias nem distopías, ele utiliza elementos de ambas para desenvolver suas narrativas e construir uma conscientização ambiental.</p>
Dois mineiros no meio de campo carioca: reflexões acerca da dialogia entre crônicas de Drummond e Campos
Authors: Ferreira Eliane Aparecida Galvão Ribeiro , Bulhões Ricardo Magalhães 
Published: December 2015

<p>Este texto tem por objetivo analisar duas crônicas: “Pelé, o Mágico”, de Drummond, e “Mané Garrincha”, de Mendes Campos. Esses textos, embora tenham sido retirados de <br />obras diversas, respectivamente, Quando é dia de futebol (2006); e O Gol é necessário: crônicas esportivas (2008), ambos tratam de um mesmo tema: futebol. Para tanto, buscamos levantar relações de reciprocidade entre essas duas obras, sempre na procura das possíveis afinidades temático-estilísticas presentes na ficção dos dois autores. Mais especificamente, pretendemos apresentar os dois livros para, em seguida, analisar as duas crônicas, tendo em vista que se aproximam, também, pelo “alumbramento” que manifestam em relação ao futebol e pela abordagem metalinguística que conferem ao tema. Para a consecução do objetivo, adotamos uma perspectiva comparativa.</p>
ELES NÃO USAM BLACK-TIE E RASGA CORAÇÃO: UMA LEITURA A PARTIR DA ÉTICA
Authors: Lima Marcelo Fernando de 
Published: December 2015

O objetivo deste trabalho é a análise das peças teatrais <em>Eles não usam black-tie</em>, de Gianfrancesco Guarnieri, e Rasga Coração, de <em>Oduvaldo Vianna Filho</em>, a partir de uma abordagem temática que privilegia a discussão ética. O artigo busca mostrar o contexto social em que as peças foram escritas e encenadas e procura resgatar seus possíveis significados políticos.
Summary Findings of a Systematic Literature Review of the Ultrasound Assessment of Bone Erosions in Rheumatoid Arthritis
Authors: Szkudlarek Marcin , Terslev Lene , Wakefield Richard J. , Backhaus Marina , Balint Peter V. , Bruyn George A.W. , Filippucci Emilio , Gandjbakhch Frederique , Iagnocco Annamaria , Mandl Peter , Möller Ingrid , Naredo Esperanza , Schmidt Wolfgang A. , d’Agostino Maria Antonietta 
Published: December 2015

Objective.Bone erosions in rheumatoid arthritis (RA) have been studied in an increasing amount of research. Both earlier and present classification criteria of RA contain erosions as a significant classification component. Ultrasound (US) can detect bone changes in accessible surfaces. Therefore, the study group performed a systematic literature review of assessment of RA bone erosions with US.Methods.A systematic search of PubMed and Embase was performed. Data on the definitions of RA bone erosions, their size, scoring, relation to synovitis, comparators, and elements of the OMERACT (Outcome Measures in Rheumatology Clinical Trials) filter were collected and analyzed.Results.The selection process identified 58 original research papers. The assessed joints were most frequently metacarpophalangeal (MCP; 41 papers), proximal interphalangeal (19 papers), and metatarsophalangeal joints (MTP; 18 papers). The OMERACT definition of RA bone erosion on US was used most often (17 papers). Second and fifth MCP and fifth MTP were recommended as target joints. Conventional radiography was the most frequently used comparator (27 papers), then magnetic resonance imaging (17 papers) and computed tomography (5 papers). Reliability of assessment was presented in 20 papers and sensitivity to change in 11 papers.Conclusion.This paper presents results of a systematic literature review of bone erosion assessment in RA with US. The survey suggests that US can be a helpful adjunct to the existing methods of imaging bone erosions in RA. It analyzes definitions, scoring systems, used comparators, and elements of the OMERACT filter. It also presents recommendations for a future research agenda based on the results of the review.
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis
Authors: Xu Dong , Huang Chiang-Ching , Kachaochana Akadia , Morgan Gabrielle A. , Bonaldo Maria F. , Soares Marcelo B. , Costa Fabricio , Sarwark John , Sredni Simone T. , Pachman Lauren M. 
Published: December 2015

Objective.To identify differentially expressed microRNA (miRNA) in muscle biopsies (MBx) from 15 untreated children with juvenile dermatomyositis (JDM) compared with 5 controls.Methods.Following MBx miRNA profiling, differentially expressed miRNA and their protein targets were validated by quantitative real-time PCR (qRT-PCR) and immunological assay. The association of miRNA-10a and miRNA-10b with clinical data was evaluated, including Disease Activity Score (DAS), von Willebrand factor antigen (vWF:Ag), nailfold capillary end row loops, duration of untreated disease, and tumor necrosis factor (TNF)-α-308A allele.Results.In JDM, 16/362 miRNA were significantly differentially expressed [false discovery rate (FDR) < 0.05]. Among these, miRNA-10a was the most downregulated miRNA in both FDR and ranking of fold change: miRNA-10a = −2.27-fold, miRNA-10b = −1.80-fold. Decreased miRNA-10a and miRNA-10b expressions were confirmed using qRT-PCR: −4.16 and −2.59 fold, respectively. The qRT-PCR documented that decreased miRNA-10a expression was related to increased vascular cell adhesion molecule 1 in 13 of these JDM cases (correlation −0.67, p = 0.012), unlike miRNA-10b data (not significant). Concurrent JDM plasma contained increased levels of interleukin (IL) 6 (p = 0.0363), IL-8 (p = 0.0005), TNF-α (p = 0.0011), and monocyte chemoattractant proteins 1 (p = 0.0139). Decreased miRNA-10a, but not miRNA-10b, was associated with the TNF-α-308A allele (p = 0.015). In the 15 JDM, a trend of association of miRNA-10a (but not miRNA-10b) with vWF:Ag and DAS was observed.Conclusion.MiRNA-10a downregulation is an important element in untreated JDM muscle pathophysiology. We speculate that muscle miRNA expression in adult dermatomyositis differs from muscle miRNA expression in untreated childhood JDM.
A Population-based Study of Intensive Care Unit Admissions in Rheumatoid Arthritis
Authors: Peschken Christine A. , Hitchon Carol A. , Garland Allan , Bernstein Charles N. , Chen Hui , Fransoo Randy , Marrie Ruth Ann 
Published: December 2015

Objective.We aimed to determine the incidence of and mortality after critical illness in rheumatoid arthritis (RA) compared with the general population, and to describe the risks for and characteristics of critical illness in patients with RA.Methods.We used population-based administrative data from the Data Repository at the Manitoba Centre for Health Policy from 1984 to 2010, and linked clinical data from an intensive care unit (ICU) database to identify all persons with RA in the province requiring ICU admission. We identified a population-based control group, matched by age, sex, socioeconomic status, and region of residence. The incidence of ICU admission, reasons for, and mortality after ICU admission were compared between populations using age- and sex-standardized rates, rate ratios, Cox proportional hazards models, and logistic regression models.Results.We identified 10,078 prevalent and 5560 incident cases of RA. After adjustment, the risk for ICU admission was higher for RA (HR 1.65, 95% CI 1.50–1.83) versus the matched general population. From 2000–2010, the annual incidence of ICU admission among prevalent patients was about 1% in RA, with a crude 10-year incidence of 8%. Compared with the general population admitted to ICU, 1 year after ICU admission, mortality was increased by 40% in RA. Cardiovascular disorders were the most common reason for ICU admission in RA.Conclusion.Patients with RA have a higher risk for admission to the ICU than the general population and increased mortality 1 year after admission. Even with advances in management, RA remains a serious disease with significant morbidity.
Patients with Rheumatoid Arthritis have Similar Excellent Outcomes after Total Knee Replacement Compared with Patients with Osteoarthritis
Authors: Goodman Susan M. , Johnson Beverly , Zhang Meng , Huang Wei-Ti , Zhu Rebecca , Figgie Mark , Alexiades Michael , Mandl Lisa A. 
Published: December 2015

Objective.Although new treatments for rheumatoid arthritis (RA) are extremely effective in preventing disease progression, rates of total knee replacement (TKR) continue to rise. The ongoing need for TKR is problematic, especially as functional outcomes in patients with RA have been reported to be worse than in patients with osteoarthritis (OA). The purpose of this study is to assess pain, function, and quality of life 2 years after TKR in contemporary patients with RA compared with patients with OA.Methods.Primary TKR cases enrolled between May 1, 2007 and July 1, 2010 in a single institution TKR registry were eligible for this study. Validated RA cases were compared with OA at baseline and at 2 years.Results.We identified 4456 eligible TKR, including 136 RA. Compared with OA, RA TKR had significantly worse preoperative Western Ontario and McMaster Universities Osteoarthritis Index pain (55.9 vs 46.6, p < 0.0001) and function (58.7 vs 47.3, p < 0.0001); however, there were no differences at 2 years. Within RA, there was no difference for patients who were treated with biologic disease-modifying antirheumatic drugs versus those who did not in pain (p = 0.41) or function (p = 0.39) at 2 years. In a multivariate regression, controlling for multiple potential confounders, there was no independent association of RA with 2-year pain (p = 0.18) or function (p = 0.71). Satisfaction was high for both RA and OA.Conclusion.Patients with RA undergoing primary TKR have excellent 2-year outcomes, comparable with OA, in spite of worse preoperative pain and function. In this contemporary cohort, RA is not an independent risk factor for poor outcomes.
Effect of Milnacipran on Pain in Patients with Rheumatoid Arthritis with Widespread Pain: A Randomized Blinded Crossover Trial
Authors: Lee Yvonne C. , Massarotti Elena , Edwards Robert R. , Lu Bing , Liu ChihChin , Lo Yuanyu , Wohlfahrt Alyssa , Kim Nancy D. , Clauw Daniel J. , Solomon Daniel H. 
Published: December 2015

Objective.Clinical trials have shown that serotonin norepinephrine reuptake inhibitors, such as milnacipran, decrease pain in noninflammatory pain conditions such as fibromyalgia and osteoarthritis. We examined the effect of milnacipran on self-reported pain intensity and experimental pain sensitivity among patients with rheumatoid arthritis (RA) with widespread pain and stable RA disease activity.Methods.In this double-blind, crossover study, patients with RA with widespread pain, receiving a stable treatment regimen, were randomized (by a random number generator) to receive milnacipran 50 mg twice daily or placebo for 6 weeks, followed by a 3-week washout and crossed over to the other arm for the remaining 6 weeks. The primary outcome was change in average pain intensity, assessed by the Brief Pain Inventory short form. The sample size was calculated to detect a 30% improvement in pain with power = 0.80 and α = 0.05.Results.Of the 43 randomized subjects, 41 received the study drug, and 32 completed the 15-week study per protocol. On a 0–10 scale, average pain intensity decreased by 0.39 (95% CI −1.27 to 0.49, p = 0.37) more points during 6 weeks of milnacipran treatment compared with placebo. In the subgroup of subjects with swollen joint count ≤ 1, average pain intensity decreased by 1.14 more points during 6 weeks of milnacipran compared with placebo (95% CI −2.26 to −0.01, p = 0.04). Common adverse events included nausea (26.8%) and loss of appetite (9.7%).Conclusion.Compared with placebo, milnacipran did not improve overall, self-reported pain intensity among subjects with widespread pain receiving stable RA medications. Trial registration:ClinicalTrials.govNCT01207453.
T2A et réification du social dans le soin : la résilience organisationnelle comme piste de solution ?
Authors: Angelé-Halgand Nathalie 
Published: December 2015

Nous montrons dans ce travail comment les différents dispositifs de pilotage de la performance hospitalière induits par la T2A et la Nouvelle Gouvernance contribuent à la marchandisation du soin, qui pousse les établissements à développer l’activité à moyens constants, et nous analysons les risques qu’une telle situation fait encourir au service public, en lien notamment avec le déni de la dimension humaine. Nous apportons des éléments nourrissant la réflexion sur les pistes de solution possibles : d’abord en nous penchant sur l’exemple des organisations de haute fiabilité, qui accordent une priorité à la sécurité, et ont développé une expertise dont nous pouvons apprendre ; puis en apportant des éléments plus théoriques ouvrant la voie à un renversement paradigmatique pour considérer le service public de santé comme un bien commun, tel que défini et étudié par Elinor Ostrom.
De la « Semaine révolutionnaire » à la « Révolution » de 1964 : itinéraires, réseaux et lieux de sociabilité de la « génération de 1922 »
Authors: Cunha Diogo Arruda Carneiro da 
Published: December 2015

Étudier les droites au Brésil – ou, dans un sens plus large, le conservatisme – n’est pas chose aisée. Cela est d’autant plus vrai quand il s’agit du domaine de la culture, en particulier dans les années 1960 et 1970. L’indéniable essor de la gauche dans la création artistique laissa dans l’ombre une élite culturelle conservatrice qui fut pourtant très active depuis la dictature de Vargas jusqu’au régime militaire. Identifier les intellectuels de cette élite à partir des itinéraires de ses membres, de ses réseaux et de ses lieux de sociabilité est le premier objectif de cet article. Le second est d’ébaucher un profil de cet acteur méconnu – ou oublié – de la vie politique brésilienne des années 1960 et 1970. Pour ce faire, nous avons mené une étude de cas : nous avons fait une prosopographie des membres de l’Académie brésilienne des Lettres entre 1961 et 1979 en repérant leur lieu de naissance et leur origine sociale, les études qu’ils ont suivies, les activités exercées, les lieux de sociabilité fréquentés et les postes politiques et administratifs qu’ils ont occupés. En plus de révéler un secteur important du champ intellectuel brésilien des années 1960 et 1970 – issu en grande partie d’une même génération, que nous appelons ici « génération de 1922 », connue particulièrement pour son rôle dans le renouveau culturel des années 1920 et pour sa participation à la dictature de Getúlio Vargas –, l’emprunt de la voie prosopographique nous a permis de saisir la formation de ce réseau et de donner une perception plus fine des rapports que ses membres entretenaient entre eux, d’une part, et avec le pouvoir politique, d’autre part.
Blunt Hepatic Trauma: Suggested Algorithm for Surgical and Nonoperative Management
Authors: Azevedo Camila Issa , Franciscani Aparecida Andrade Ribeiro , Souza Amanda Baraldi , Filho Fabio Mendes Botelho , Starling Sizenando Vieira 
Published: December 2015

ABSTRACT

Objective
This study aims to analyze the outcomes of blunt hepatic trauma, and compare operative treatment (OT) and nonoperative management (NOM) emphasizing the stratified results by grade of injury and failure rate.

Materials and methods
This is a prospective study of cases admitted to João XXIII Hospital, located in Belo Horizonte, Brazil, from January 2013 to December 2013. Patients were admitted with blunt hepatic trauma on emergency room (ER) and were divided into two groups. One group contained patients who met the criteria for NOM, and the other group was formed by patients with surgical indication.

Results
During the study period, 47 patients were admitted with blunt liver injury and 43 (91.4%) met the inclusion criteria for NOM. The rate of NOM failure was 9.3%: 50% of them had grade II injury and 50% had grade V. The patients with grade II injury had also extrahepatic lesions and, in those with grade V, the failure was due to bleeding.

Conclusion
Nonoperative management has become the standard of care for patients with blunt liver injuries in trauma centers. However, as grade V injuries have a higher failure rate, they might receive special attention from the surgical team.

How to cite this article
Azevedo CI, Franciscani AAR, Souza AB, Filho FMB, Starling SV, Drumond DAF. Blunt Hepatic Trauma: Suggested Algorithm for Surgical and Nonoperative Management. Panam J Trauma Crit Care Emerg Surg 2015;4(1):1-5.
Pediatric and Adult Blunt Traumatic Bladder Rupture: A Comparative Review
Authors: Tyroch Alan Henry , Matlock Kinzie 
Published: December 2015

ABSTRACT

Background
To determine the incidence, features and associated injuries of pediatric bladder rupture (BR) vs adult BR due to blunt trauma.

Materials and methods
A retrospective study from 1st January 2001 to 31st December 2012 was performed for blunt traumatic BR in pediatric and adult patients. Demographics, mean injury severity score, mean length of stay, incidence, mortality, diagnostic modality, management and associated injuries were evaluated.

Results
Of 4,884 pediatric blunt trauma admissions, eight children had BR. Sixty-six adults sustained BR out of 18,283 blunt trauma admissions. Gross hematuria was present in a majority of both groups. Computed tomography (CT) cystogram was the most frequent diagnostic modality utilized. Pelvic fracture and intra-abdominal injury were the most commonly associated injuries in both groups.

Conclusion
Although blunt traumatic BR is extremely rare, BR is associated with high injury severity score, prolonged length of stay and associated injuries. Diagnosis and treatment are essentially identical for both population. All patients with gross hematuria (with or without pelvic fracture), microscopic hematuria with anterior pelvic fracture and pelvic fracture with pelvic fluid on CT scan warrant evaluation with cystography. Intraperitoneal BR and combined intraperitoneal and extraperitoneal BR should be repaired operatively. Most extraperitoneal BR may be treated nonoperatively with transurethral catheter.

How to cite this article
Tyroch AH, Matlock K. Pediatric and Adult Blunt Traumatic Bladder Rupture: A Comparative Review. Panam J Trauma Crit Care Emerg Surg 2015;4(1):11-15.
Descending Necrotizing Cervicomediastinitis Secondary to Esophageal Perforation: Management in a Hospital with Limited Resources
Authors: Molina Juan Carlos Salamea , Arízaga Sofia , Rodas Edgar Bruck , Pino Raul , Reinoso Jeovanni 
Published: December 2015

ABSTRACT
The esophageal perforation is the result of an iatrogenic cause, spontaneous cause or external trauma. The injury belonging to trauma can have different etiologies, such as the ones that are caused because of strange bodies or caustic substances. Within complications that can appear in esophageal perforation, we have the descending necrotizing mediastinitis, which is a mediastinal infection that starts in the oropharyngeal area. The spread of the infection through the anatomical spaces to the mediastinum can produce a mortality of 67%.

How to cite this article
Arízaga S, Rodas EB, Pino R, Reinoso J, Salamea JC. Descending Necrotizing Cervicomediastinitis Secondary to Esophageal Perforation: Management in a Hospital with Limited Resources. Panam J Trauma Crit Care Emerg Surg 2015;4(1):23-29.
Prospective Evaluation of a Protocol of Whole Body CT based only in Mechanism of Injury in Major Trauma Patients
Authors: Silva Eduardo Rissi , Rossi Felipe , Mori Newton Djin , Garcia Diogo FV , Utiyama Edvaldo 
Published: December 2015

ABSTRACT

Background
There is an important increase in the use of whole body computed tomography (WBCT) around the world although its benefits are still controversial.
We hypothesized that the use of a WBCT protocol in the major trauma patients based on mechanism of injury alone would reduce the number of injuries that would have been missed if CT was only done based on clinical findings.

Study design
A prospective observational study with the inclusion of 144 patients with major blunt trauma during 5 months at our academic center. Data were collected from all patients including: epidemiology, clinical status on scene and at the emergency department, time of the scan (including patient handling), clinical findings during initial assessment and WBCT scan findings, dividing exams in with or without findings (normal). Looking for findings that would go unnoticed if CT was done based on clinical findings. Glasgow coma scale (GCS) 15 and GCS <15 were compared and data are presented as absolute values of mean ± SD. Analysis of data was done with Chi-square test (p < 0.05).

Results
One hundred forty-four patients with major trauma that were included in the protocol. Normal CT scan was found in 44 cases and 100 scans had at least one positive finding associated with the trauma and 35 CTs (25%) had at least one injury that would be missed without the WBCT protocol. Glasgow coma scale of 15 patients and those with 14 or less were compared regarding the number of normal vs positive scan (p = 0.45) and for scans with unnoticed injuries (p = 0.1) and there was no difference between the two groups.

Conclusion
A significant number of injuries would have been missed if a WBCT scan protocol based on mechanism of injury was not used in our center. There was no difference in the number of probably missed injuries in patients with a GCS = 15 or those with GCS ≤14.

How to cite this article
Silva ER, Rossi F, Mori ND, Garcia DFV, Utiyama E. Prospective Evaluation of a Protocol of Whole Body CT based only in Mechanism of Injury in Major Trauma Patients. Panam J Trauma Crit Care Emerg Surg 2015;4(2):66-69.