bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparison of efficacy of Escitalopram and Bupropion in treatment of depression symptoms in patients with heart failure: randomized clinical trial
Authors: Hamzehpour Romina , Hamidia Angela , Ramezani Azadeh , Abrootan Saeed , Shirafkan Hoda , Moallem Hirbod Hadizadeh , Tavakoli Negin , Ziaie Naghmeh 
Published: September 2024

Objective:
This study aims to compare the effects of two medicines, Escitalopram and Bupropion, on HF patients who have depression symptoms.

Methods:
This double-blind randomized clinical trial study was conducted on HF patients with depression symptoms at the Heart Failure Clinics affiliated with Babol University of Medical Sciences. In this study, 80 participants were examined for depression based on the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS). They were randomly allocated into two groups of 40 participants treated with Bupropion 75 mg and Escitalopram 5 mg. Following the intervention, the individuals were assessed in terms of their depression score at 4, 8, and 12-week intervals. Finally, the data were analyzed using SPSS version 22.0.

Results:
In the examination of Beck and Hamilton scores in the two research groups during different follow-ups, a significant decrease was found over time (P<0.001 for both medicines). While the effectiveness of the two medicines was the same at different times (P>0.05 in all cases). Comparing the side effects between the two intervention groups, the orgasm disorder (P=0.018) and sexual dysfunction (P<0.001) were reported significantly more in the Escitalopram group than in the Bupropion group.

Conclusions:
The findings of this study showed that Escitalopram has the same efficacy as Bupropion in the treatment of depression symptoms in HF patients.
Advances in Reconstructive Robotic Microsurgery in the Extremity
Authors: Könneker Sören , Watson Jennifer Ashley , Weinzierl Andrea , von Reibnitz Donata , Besmens Inga , Kim Bong-Sung , Giovanoli Pietro , Lindenblatt Nicole 
Published: September 2024

Robotic surgery has emerged as a promising technique for reconstructive procedures, offering potential advantages across various surgical fields. Following initial case reports on the use of the Symani Surgical System (Medical Microinstruments, S.p.A) for microsurgical anastomosis, the authors evaluated its full potential in extremity reconstruction. They conducted a retrospective analysis of patients with soft tissue defects of the upper and lower extremities treated between February 2022 and May 2024. Each patient underwent soft tissue reconstruction with free tissue transfer with microsurgical anastomosis performed using the Symani Surgical System. The study included 7 male patients and 1 female patient, aged between 19 and 71 years (mean age: 50.6 y). The most used recipient vessels were the anterior tibial artery and vein (37.5%). The preferred anastomotic technique was end-to-side in arterial anastomoses (6/8). All arterial anastomoses were performed using the Symani Surgical System. The mean anastomosis time was 33.2±5.8 minutes. One out of 8 patients required surgical revision outside of the anastomosis. The authors’ findings suggest that using the Symani Surgical System for microanastomosis in extremity reconstruction is a safe and effective approach, leading to satisfactory outcomes in different anatomic regions. The system allows for the successful execution of various anastomosis techniques, including end-to-end and end-to-side connections, using single interrupted or running sutures, which enhances its versatility in complex reconstructive procedures. The benefits of robotic assistance in terms of precision and ergonomics are promising for the future of reconstructive microsurgery.
Genome assembly ofFirmina major, an endangered savanna tree species endemic to China
Authors: Yang Jing , Zhang Rengang , Ma Yongpeng , Ma Yuqian , Sun Weibang 
Published: September 2024

AbstractThe tree speciesFirmiana majorwas once dominant in the savanna vegetation of the arid hot valleys of southwest China, but was considered extinct in the wild in 1998. After eight small populations were relocated by thorough investigations between 2018 and 2020, the species was subsequently recognized as a Plant Species of Extremely Small Populations (PSESP) in China in need of urgent rescue. Moreover, due to severe human disturbance, other species in the tropical woody genusFirmianaare also endangered, and the species in this genus have almost all been listed as second-class National Protected Wild Plants in China. In order to guide future research into the conservation of this group, we present here the high-quality genome assembly ofF. major. This is the first genome assembly in the genusFirmiana, and is 1.4 Gb in size. The assembly consists of 1.18 Gb repetitive sequences, 37,673 annotated genes and 31,965 coding genes.
Boosting forward connectivity between primary visual and body selective cortex reduces interference between sex and emotion judgements of bodies
Authors: Gandolfo Marco , D’Argenio Giulia , Downing Paul E. , Urgesi Cosimo 
Published: September 2024

AbstractWe effortlessly categorise other people along socially relevant categories such as sex, age, and emotion. A core question in social vision relates to whether we perceive these categories independently or in relation to each other. Here, we investigated categorisation of sex and emotion from the body, finding that participants generally fail to fully ignore task-irrelevant variations of sex while judging body emotional expressions. In contrast, sex categorisation was unaffected by variations in emotional expression. This asymmetric interaction between sex and emotion may arise because of bottom-up visual processing, due to partially shared visual features used for both judgments, or because of top-down, categorical associations between sex and emotion categories. To disentangle these possibilities, we used cortico-cortical paired associative stimulation (ccPAS) to modulate the connectivity between primary visual cortex and the extrastriate body area. We posited that boosting forward connectivity between these regions would increase efficiency of feature-based processing, while boosting feedback connectivity would enhance the separability of semantic categories related to sex and emotion. We found that boosting forward connectivity eliminated the interference of sex on emotion judgments, while that interference remained unaffected with modulation of feedback connectivity. These findings suggest that interactions between sex and emotion in body perception emerge during the perceptual analysis of the stimuli, and add to our understanding of person perception and social categorization.
Partial repair causes permanent defects in papillary structure and function after reversal of urinary obstruction
Authors: Vanichapol Thitinee , Gonzalez Alex , Delgado Rachel , Brewer Maya , Clouthier Kelly A. , Menshikh Anna , Snyder William E. , Rahman Teebro , Sander Veronika , Yang Haichun , Davidson Alan , de Caestecker Mark 
Published: September 2024

AbstractUrinary obstruction causes injury to the renal papilla and leads to defects in the ability to concentrate urine which predisposes to progressive kidney injury. However, the regenerative capacity of the papilla after reversal of obstruction is poorly understood. To address this, we developed a mouse model of reversible urinary obstruction which is characterized by extensive papillary injury, followed by a robust regeneration response and complete histological recovery over a 3- month period. However, these mice have a pronounced defect in urinary concentrating capacity. We now show that this is due to permanent changes in the composition, organization, and transcriptional signatures of epithelial, endothelial, and interstitial cell lineages in the papilla. There are persistent inflammatory responses that are also seen in patients with renal stone disease but are associated with cell-specific adaptive responses to the increasingly hypoxic environment of the papilla after reversal of obstruction. Taken together, our analysis of a new model of reversible urinary obstruction reveals that partial repair leads to permanent changes in the structure and function of all of the major cellular compartments in the papilla that include both shared and distinct responses to different types of renal papillary injury in humans and mice.SummaryPartial repair after reversal of urinary obstruction leads to permanent changes in structure and function of all major cellular compartments in the renal papilla
Structure of small HBV surface antigen reveals mechanism of dimer formation
Authors: He Xiao , Kang Yunlu , Tao Weiyu , Xu Jiaxuan , Liu Xiaoyu , Chen Lei 
Published: September 2024

AbstractHepatitis B surface antigen (HBsAg), the only membrane protein on the HBV viral envelope, plays essential roles in HBV assembly, viral release, host cell attachment, and entry. Despite its functional and therapeutic importance, the detailed structure of HBsAg has remained enigmatic. Here, we present the core structure of HBsAg at 3.6 Å resolution, determined using recombinant small spherical subviral particles (SVPs). The structure reveals how two HBsAg monomers interact to form a dimer, which is the basic building block of SVPs.
Role of local structure in the optical and electronic properties of oxygen vacancies in different crystal phases of
Ga2O3
Authors: Kaewmeechai Chaiyawat , Strand Jack , Shluger Alexander 
Published: September 2024

We investigate the structural, electronic, and optical properties of oxygen vacancies (VO) in crystalline α, β, and ε−Ga2O3 using density functional theory (DFT) calculations with the PBE0-TC-LRC functional. Our results reveal that the charge transition levels (CTLs) associated with VO exhibit significant variations depending on the crystal phase and the coordination environment of surrounding atoms. In particular, VOs surrounded by tetrahedral Ga atoms (T-Ga) exhibit deeper CTLs compared to those surrounded by octahedral Ga atoms (O-Ga). We also observe distinct atomic relaxations, with larger displacements of T-Ga atoms compared to O-Ga atoms in the vicinity of VOs. Using linear-response time-dependent DFT, we investigate the optical transitions of VO and identify two distinct types of transitions: defect state to conduction band state and valence band to defect state. These results can be used to better understand the optical properties of VO defects in Ga2O3 films.

Published by the American Physical Society
2024
A decision-support system for choosing between traditional and alternative project delivery methods for bundled projects
Authors: Assaf Ghiwa , Assaad Rayan H. 
Published: September 2024

PurposeProject bundling is an innovative practice that groups or bundles several infrastructure projects into a single contract. While project bundling has various benefits, agencies are facing some challenges when bundling their projects, including properly assessing the feasibility (or infeasibility) of project delivery methods (PDMs) of interest. More specifically, project owners face the challenge of properly selecting between traditional and alternative PDMs for their bundled projects. Although some research efforts were devoted to providing guidelines in relation to different aspects related to project bundling, no previous study was conducted to help project owners performing PDMs-related feasibility analysis for bundled projects, which differ from normal, singly delivered projects. To fill this knowledge gap, this paper develops a decision-support tool that assists agencies in deciding whether they should select a traditional or alternative PDM (i.e. whether to go with the Design-Bid-Build (DBB) PDM or not) for their bundled projects.Design/methodology/approachAn analytical methodology comprised of four main steps was followed in this paper. First, an expert survey was developed and distributed to industry experts to quantify the importance of 25 project bundling objectives. Second, principal component analysis was used to determine the weights for the different project bundling objectives. Third, a series of statistical tests was implemented to identify different feasibility tiers. Fourth, a user-friendly decision-support tool was developed, and its capabilities were demonstrated.FindingsThe results showed that six tiers exist to classify the feasibility (or infeasibility) of traditional PDMs (i.e. the DBB method) for bundled projects. The research outcomes have also reflected that the following five project bundling objectives contribute the most to making traditional PDMs (i.e. the DBB method) more feasible for bundled projects: (1) Having well-defined design features; (2) Requiring prior knowledge or experience with similar project size and scope; (3) Completing the overall project on schedule; (4) Keeping rate of expenditures within cash flow plan; and (5) Acquiring specific legislative, regulatory and jurisdictional requirements early on.Originality/valueThis research adds to the body of knowledge by equipping agencies and project owners with a decision-support system that helps them identify whether traditional or alternative PDMs are more appropriate for the specific objectives of their bundling program(s). By making the right PDM decision, project owners can enhance their bundling practices (especially in relation to the PDM proper selection) and ultimately the performance of their bundled projects.
Monotonic unbounded schemes transformer (MUST): an approach to remove undershoots and overshoots in family of unbounded schemes using finite-volume method
Authors: Yap Y.F. , Chai J.C. 
Published: September 2024

Purpose
This paper presents a Monotonic Unbounded Schemes Transformer (MUST) approach to bound/monotonize (remove undershoots and overshoots) unbounded spatial differencing schemes automatically, and naturally. Automatically means the approach (1) captures the critical cell Peclet number when an unbounded scheme starts to produce physically unrealistic solution automatically, and (2) removes the undershoots and overshoots as part of the formulation without requiring human interventions. Naturally implies, all the terms in the discretization equation of the unbounded spatial differencing scheme are retained.

Design/methodology/approach
The authors do not formulate new higher-order scheme. MUST transforms an unbounded higher-order scheme into a bounded higher-order scheme.

Findings
The solutions obtained with MUST are identical to those without MUST when the cell Peclet number is smaller than the critical cell Peclet number. For cell Peclet numbers larger than the critical cell Peclet numbers, MUST sets the nodal values to the limiter value which can be derived for the problem at-hand. The authors propose a way to derive the limiter value. The authors tested MUST on the central differencing scheme, the second-order upwind differencing scheme and the QUICK differencing scheme. In all cases tested, MUST is able to (1) capture the critical cell Peclet numbers; the exact locations when overshoots and undershoots occur, and (2) limit the nodal value to the value of the limiter values. These are achieved by retaining all the discretization terms of the respective differencing schemes naturally and accomplished automatically as part of the discretization process. The authors demonstrated MUST using one-dimensional problems. Results for a two-dimensional convection–diffusion problem are shown in Appendix to show generality of MUST.

Originality/value
The authors present an original approach to convert any unbounded scheme to bounded scheme while retaining all the terms in the original discretization equation.
Project governance: the impact of environmental changes on governance adaptations in large-scale projects
Authors: Ika Lavagnon , Meredith Jack , Zwikael Ofer 
Published: September 2024

PurposeThe performance of large-scale projects is often challenged due to major environmental changes that occur during their life. However, literature has paid little attention to the governance adaptations required to respond effectively to these changes. This paper aims to study changes in the project environment over time, the corresponding governance adaptations and their impact on project performance.Design/methodology/approachTo ensure triangulation between two sources of evidence, we used both primary and secondary data sources and examined 14 projects through 2 studies, the first focused on seven documented, illustrative case projects and the second on interviews with senior and project managers involved in seven additional projects.FindingsWe found the key environmental changes that should trigger appropriate governance adaptations to be market evolutions, technological advancements and sociopolitical events. However, we also found that these necessary governance adaptations are not commonly implemented timely, sufficiently or effectively.Originality/valueThe paper distills the dynamics of large-scale projects in achieving project effectiveness and raises theoretical propositions on the combination of environmental changes and deficient governance adaptations that, over time, turns efficient projects into ineffective projects and discusses implications for theory and practice.
Relational business model for shared responsibility
Authors: Wieland Josef , Geraldo Schwengber Jessica 
Published: September 2024

Purpose
This paper aims to contribute to the literature on corporate and leadership responsibility by proposing a relational business model for shared responsibility.

Design/methodology/approach
First, a literature review on corporate and leadership responsibility is presented and discussed. This is followed by an overview of existing public and private regulations and future perspectives that enforce and/or foster corporate and leadership responsibility. Based on the concepts of relational economics, relational leadership and proactive regulation, the theoretical foundations of a relational business model are derived. In addition, a decision model for the empirical application of the relational business model in ethical dilemma situations is developed and presented.

Findings
Theoretical elaboration of a relational business model and an associated relational decision-making approach.

Originality/value
This study contributes to a new way of doing business in terms of shared responsibility. Furthermore, corporate responsibility and leadership responsibility are usually researched as two distinct fields, with the former referring to the meso level and the latter to the micro level. A relational approach, which views leadership as a relational phenomenon, contributes to bridging both concepts.
Effects of escape room game‐based civics education on junior high school students' learning motivation, critical thinking and flow experience
Authors: Chen Hsiu‐Ling , Yohannes Abebayehu , Hung Ning‐Li 
Published: September 2024

AbstractThe escape room game is an example of digital game‐based learning that has become a popular learning tool in recent years. However, not enough is known about enthusiasm for and promising reports of the use of escape rooms in education. The purpose of this study was to investigate the effects of escape room game‐based civics education on eighth grade students' learning motivation, critical thinking and flow experience. To explore the effects, a quasi‐experimental pretest–posttest with a control group design method was employed. The participants were 76 eighth grade students. The subjects were divided into two groups: the experimental group, which used an escape room game, and the control group which used the Google classroom digital platform. The results of the study indicated that there was a significant difference between the two groups in favour of the experimental group in terms of learning motivation. There was a significant difference between the two groups' critical thinking in favour of the experimental group for the ‘assumption’ and ‘interpretation’ subscales of the critical thinking test. Regarding flow experience, the experimental group performed significantly better than the control group. Finally, based on the research results, suggestions are made for the future use of escape room games for teaching and for future research.
Practitioner notesWhat is already known about this topic

Escape room games have substantial potential for enhancing learning, motivation and critical thinking.
Studies promoting mental flow, integrating complex skills and using multiple strategies in a game context are limited.
What this paper adds

Students' mind flow experience and critical thinking were enhanced through escape room games.
The escape room game made the learning process more varied, triggered students' interest, and improved their learning motivation.
This study compared the effect of escape room game‐based learning with the Google Classroom platform, not the traditional teaching approach.
Implications for practice and/or policy

Escape room games offer learners innovative opportunities to develop critical thinking skills.
Using an appropriately designed escape room as a game‐based learning environment is an effective and motivating game‐based learning approach.
The realistic and interactive nature of escape room games is an important factor that influences learners' mind‐flow experiences.
Unlocking the multifaceted molecular functions and diverse disease implications of lactylation
Authors: Jing Fengyang , Zhang Jianyun , Zhang Heyu , Li Tiejun 
Published: September 2024

ABSTRACTIn recent years, a significant breakthrough has emerged in biology, the identification of lactylation, a novel post‐translational process. This intriguing modification is not limited to a specific class of proteins but occurs across a diverse range, including histones, signalling molecules, enzymes, and substrates. It can exert a broad regulatory role in various diseases, ranging from developmental anomalies and neurodegenerative disorders to inflammation and cancer. Thus, it presents exciting opportunities for exploring innovative treatment approaches. As a result, there has been a recent surge of research interest, leading to a deeper understanding of the molecular mechanisms and regulatory functions underlying lactylation within physiological and pathological processes. Here, we review the detection and molecular mechanisms of lactylation, from biological functions to disease effects, providing a systematic overview of the mechanisms and functions of this post‐translational modification.