bluuebunny/crossref_metadata_2025_split huggingface dataset:
GAMBARAN KLINIS DAN LABORATORIUM SINDROM SYOK DENGUE RAWAT PICU RSU DR. SAIFUL ANWAR MALANG
Authors: Budhy Setya , YS Mardhani , Muid Masdar 
Published: January 2017

ABSTRACTÂ Dengue shock syndrome (DSS) is a clinical emergency case with still high mortality rate. During five years period (1January 1997â€“31Â December 2001) total case of SSD triaded in PICU room Medical Faculty Brawijaya University/ Saiful Anwar Hospital Malang wereÂ thirty two patients. They were referred from Malang regency 9 patients (28%), Malang city 23 patients (72%). The most group age 6 â€“Â 10 years 14 patients (44%), < 5 years 13 patients (41%), 11 â€“ 14 years 5 patients (15%). SSD is devided in DBD grade III 14 patientsÂ (44%), DBD grade IV 18 patients (56%). Laboratory finding total leucocyt count < 4000/mm3Â 8 patients (25%), Â 4000 â€“ 10000/mm3Â 24Â patients (75%). Total thrombocyt < 50000 / mm3Â 22 patients (69%), 50000 â€“ 100000/ mm3Â 10 patients (31%). Hematocrit > 42% allÂ patients (100%). Clinical sign found in SSD patients quickly and fine pulse 14 patients (44%), cold extremities 32 patients (100%),Â pulse not palpable 18 patients (56%). Blood tension : unmeasured 18 patients (56%), hypotension 18 patients (56%). Death patientsÂ 13 (41%) recovery patients 19 (59%). All SSD patients Â (100%) Â were death by complication of occult bleeding, pulmonary edema,Â respiratory failure.
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SERANGAN AKUT ASMA DENGAN KADAR IgE, IFN- DAN IL-4 TOTAL SERUM
Authors: Kusuma HMS. Chandra , Kalim Kusworini Handono , Riawan Wibi , Muid Masdar 
Published: January 2017

ABSTRACTÂ Acute bronchial asthma is a common medical emergency the world over. There now exists compelling evidence of a role for Th2-Th1Â paradigm in the pathogenesis of asthma in children. We hypothesized that childhood asthma is associated with the activation of Â Th2-Th1 lymphocytes whose products regulate at least in part, the expression of IgE, IFN-Î³ and IL-4 and thereby disease severity. OurÂ aims, therefore were to compare the level of total IgE, total IL-4 and total IFN-Î³ in serum from asthmatic and non asthmatic controlÂ children matched for age and sex, and to attempt to correlate the IgE, IL-4, and IFN-Î³ total level of serum in the asthmatics childrenÂ with disease severity. Fifty one children with acute asthma exacerbation were compare with thirty one no asthmatics normal childrenÂ matched for age and sex. The level of IgE, IL-4, and IFN-Î³ were measured using Elisa. Asthma severity was assessed by a symptomÂ score and spirometri. The level of IgE and Il-4 in the serum of the asthma were elevated as compared to the non asthmatic normalÂ controls, whereas the IFN-Î³ was decreased. There was a significant correlation between elevated levels of IgE and IL-4 with the acuteÂ asthma exacerbation severity, whereas the decreased level of IFN-Î³ was not. Conclusions. The increased levels of IgE , IL-4 and theÂ ratio of Â IL-4/IFN-Î³ play a crucial role in the acute asthma exacerbation severity.
DIARE ROTAVIRUS PADA ANAK DIBAWAH USIA 3 TAHUN YANG DIRAWAT DI RSU DR. SAIFUL ANWAR MALANG TAHUN 2005 (PRELIMINARY STUDY)
Authors: Santoso Nurtjahjo Budi , Hamid Aulia Abdul , Santoso Sanarto 
Published: January 2017

ABSTRACTÂ Rotavirus is the most common cause of acute diarrhea among children worldwide. The majority of the cases required hospitalization.Â Epidemiologic pattern and clinical manifestation could be helpful in establishing the proper diagnosis and management. To find outÂ prevalence and the clinical pictures of rotavirus diarrhea among children under three years of ages with acute diarrhea admitted in theÂ Department of Child Health Dr. Saiful Anwar General Hospital. The stools of children under three years of age with acute diarrheaÂ between March 1stÂ and May 1st, 2005 were assessed for rotavirus using Latex agglutination test (Slidex, Rota K2, bio Merieux). Age,Â sex, clinical sign and symptoms and breast-fed were recorded. The severity of acute diarrhea was estimated using WHO criteria.Â Statistical analysis were performed using EpiInfo 2000 program with x2Â or x2Â for trend. From the 40 patients with acute diarrhea wereÂ found 16 patients (40%) with rotavirus positive, both male and female were 8 patients (50%). Distribution of rotavirus positive patientsÂ in age group were 0-5 months 3/16 (18,7%), 6-11 months 6/16 (37,5%), 12-23 months 6/16 (37,5%) and 24-36 months 1/16 (6,3%).Â Clinical manifestations showed that most children had fever (75%), vomiting (87.5%) and dehydration (87.5%). Rotavirus infectionÂ among breast-fed patients were found less than bottle-fed patients.
PENGARUH KADAR TROMBOSIT, HEMATOKRIT, HEMOGLOBIN DARAH DAN PROTEIN URIN PADA IBU PREEKLAMSI /EKLAMSI TERHADAP NILAI APGAR BAYI YANG DILAHIRKAN
Authors: Kawuryan Siti Lintang 
Published: January 2017

ABSTRACTÂ Preclapmsi or eclampsia is one of the risk factor for asfiksia on newborn that can predicted by lower Apgar score. The aim of thisÂ research Â is Â to Â know Â the Â influence Â of Â the Â trombocyte, Â hematokrit, Â hemoglobin, Â and Â urinary Â protein Â examination Â of Â preclampsi Â orÂ eclampsi mother to babyâ€™s Apgar score. This research was a diskriptive-cross sectional retrospective study with Chi- square test,Â Fisher test x2 for trend statistic analysis. Total sample was 100 which choosen by simple random sampling. The parameter of thisÂ study was trombocyte, hematokrit, hemoglobin, and urinary protein examination of preclampsi or eclampsi mother and babyâ€™s ApgarÂ score. There was a significant influence relationship between the raise of blood hematocrit (p=0,0243), the decrease of the bloodÂ trombocyte (p= 0,0175) and the high level of proteinuria (p=0,0154) of preclampsi or eclampsi mother Â to babyâ€™s Apgar score. In theÂ other hand, hemoglobin (p =0,3589), SGOT (p=0,5447),SGPT (p= 0,4850), Ureum (p = 0,1964), kreatinin (p= 0,3415) level was notÂ significantly influence. The conclusion of this reseach is hematokrit â‰¥ 38 % and urinary protein â‰¥ 4+ on preclampsi or eclampsi motherÂ are usefull for predicting lower Apgar score of the neonate with relative risk 7,609.Â Keyword: preclampsi or eclampsi, trombocyte, hematokrit, hemoglobin, and urinary protein examination, Agar score
PENATALAKSANAAN SINDROMA MAYER ROKITANSKY KUSTER HAUSER (SINDROMA MRKH) DENGAN SINDROMA KLIPPEL FEIL
Authors: Wiyasa IW Arsana , Mukminah Aisyatul 
Published: January 2017

ABSTRACTÂ It was reported that a 19 year old woman, suffered from Muller duct agenesis. The patient came to RSSA, complained about primaryÂ amenorrhea and assimetrical of head position. Tuba, uterus and 2/3 proximal vagina were not formed. Both of ovaries seemedÂ normal. Based on vaginal sondage, the vagina canal is only 1.5 cm. Secondary sexual characteristics developed normally. By skullÂ and cervical X â€“ ray, it was found fusion of vertebrae cervical 3, 4. The vagina and the uterus are not present, but the tuba and theÂ ovarium are normal; this case is known as Mayer Rokitansky Kuster Hauser Syndrome. Moreover, it is accompanied by anotherÂ congenital defect, i.e. fusion of vertebrae cervical 3 and 4, which is called Klippel Feil Syndrome. In the exploration, it was found thatÂ there was a constitution of cromosom 46,XX. It has been done hormonal examination: FSH, LH, estrogen, prolactin and was obtainedÂ testosteron < 127.8 ng/dl. The patient was grews up as a woman. Her behavior, attitude, emotion and sexual behavior are likely aÂ woman. Â We plan to perform and suggest her to adopts a child. To treat the Klippel Feil, it is important prevention of the neck traumaÂ and complication of neurology and arthritis.Â Key word : Mayer Rokitansky Kuster Hauster Syndrome, Klippel Feil Syndrome, vaginoplasty
PENGARUH PEMBERIAN TEMULAWAK PADA LAMBUNG TIKUS YANG MENGALAMI ULKUS PEPTIKUM AKIBAT INDUKSI INDOMETASIN
Authors: Indraswari Cokorde Istri , Kalsum Umi , Sudjari Sudjari 
Published: January 2017

ABSTRACTÂ The flavonoid content of Curcuma xanthorriza has an anti inflamatory effect. Inflamation is the basic mechanism in the occurrence ofÂ indomethacine induced peptic ulcer. The purpose of this research was detect the effect of the administration of Curcuma xanthorrizaÂ decoction in reducing the occurrence of indomethacine induced peptic ulcer. The research methodology used post test control groupÂ design. Randomly selected sample of 20 male wistar rat were classified into four groups. Group I (positive control, received 30 mg/kgÂ bodyweight indomethacine), group II (dosage 1, received 30 mg/kg bodyweight indomethacine and 1,3 g/kg bodyweight CurcumaÂ xanthorriza Â decoction), Â group Â III Â (dosage Â 2, Â received Â 30 Â mg/kg Â bodyweight Â indomethacine Â and Â 2,6 Â g/kg Â bodyweight Â CurcumaÂ xanthorriza decoction), and group IV (dosage 3, received 30 mg/kg bodyweight indomethacine and 5,2 g/kg bodyweight CurcumaÂ xanthorriza Â decoction). Â Indomethacine Â and Â Curcuma Â xanthorriza Â was Â given Â by Â intragastric Â administration. Â The Â parameter Â to Â beÂ measured was the number of macroscopic gastric hemorrage lesion, because gastric hemorrage is the early manifestation of pepticÂ ulcer. The result of this research was there is a significant difference in the number of macroscopic gastric hemorrage lesion betweenÂ group I and the other three group (F test, p<0,05), and there is no significant difference for those of group II, III, and IV (F test,Â p>0,05). Conclusion: Curcuma xanthorriza can reduce the occurrence of peptic ulcer.Â Key words: Indomethacine, Curcuma xanthorriza, Peptic ulcer, Gastric hemorrage lesion
EVALUASI HASIL PELATIHAN DAN PENDIDIKAN UNTUK PENANGANAN PRA RUMAH SAKIT TERHADAP PENDERITA CEDERA
Authors: Soemarko M. 
Published: January 2017

ABSTRACTÂ The Â purpose Â of Â organized Â trauma Â system Â management Â of Â pre Â hospital Â care Â of Â seriously Â injured Â patients Â is Â to Â ensure Â the Â earlyÂ intervention and transfer savely the patients to the best equipped facility to care of their injuries. The aims this research is to evaluateÂ the results and the effectiveness of the training and education of pre hospital management in Saiful Anwar Hospital. Â The method thisÂ research are an observational study of injured traffic accident patients preHospital care in Saiful Anwar General Hospital Malang.Â Training and education have been done intensively and continuously after August 1999 until now. The comparation was between 1stÂ April until 31stÂ Juli 1999 and 1stÂ April until 31stÂ Juli 200. The result of this research, a significant progress in pre hospital treatment,Â ambulance transportation and communication between field attendance and the trauma center. But significantless of progression inÂ pre hospital medical records. Only reveral system from health center was significant developed. The intensive training and educationÂ of pre hospital management to the injured patient had a significant good results. The training and education must be continued andÂ developed for a better results in the future. Â Key words : Injured patients, pre hospital care, training and education.
TRANSFEKSI DNA KE DALAM MITOKONDRIA SEL BETA PANKREAS TIKUS DAN SEL PRIMER MYOBLAST MANUSIA: LANGKAH MENUJU REKAYASA DNA MITOKONDRIA DAN TERAPI GEN
Authors: Lyrawati Diana 
Published: January 2017

The delivery of an exogenous or modified DNA into the mitochondria of mammalian cells has been proposed as an alternative way toÂ prevent or modify mitochondrial genetic defect. In Â this study, a lipofection method was developed to transfer exogenous DNA intoÂ mitochondria of BRIN BD11 cells, a rat beta pancreas cell line, and human myoblast primary cells. An artificial mini-mitochondrialÂ genome carrying a reporter gene encodes for a mitochondrial green fluorescent protein (mtGFP) was usedto track the fate of theÂ exogenous DNA following its transfection into cellular mitochondria. Epifluorescence microscopic observation was carried out toÂ detect the green fluorescence resulted from the GFPexpression. Immunohistochemical assays were also performed to validate andÂ confirm the GFP expression. Collectively, the results indicate that the exogenous DNA pmtGFP could be Â delivered into theÂ mitochondrial compartment and was functional withinthe mitochondria of BRIN BD11 and human myoblast cells. Such achievementÂ is a significant progress as both the artificial DNA construct and the mitochondrial transfection method could serve as a model toÂ study the dynamic of mutant mtDNA as well as to provide a basis for the development of gene therapy for human mitochondrialÂ diseases.Â Key words: DQAsome, pmtGFP, beta pancreas cell line, human myoblast primary cells
PENGARUH EKSTRAK BIJI NIMBA (Azadirachta indica) TERHADAP PENURUNAN DERAJAT PARASIT DAN JUMLAH HEMOZOINPADA KULTUR Plasmodium falciparum
Authors: Aini Noer , Soebaktiningsih Soebaktiningsih , Fitri Loeki Enggar , Kalsum Umi , Sumarno Sumarno 
Published: January 2017

Malaria infection is still one of world healthâ€™s problems that cause a high death rate (20.9% - 50%). One of the reason is PlasmodiumÂ falciparum resist to conventional anti-malarial drugs. Neem seeds extract had been reported has antimalarial effect by decreasingÂ parasitemia, but there has not been any report on its effect in inhibition hemazoin formation. The aimof this research was to find theÂ effect of Neem seeds extract on parasitemia and hemazoin level in Plasmodium falciparum culture. Laboratory experiment was doneÂ by using Papua isolate of Plasmodium falciparum (2300) from NAMRU 2 Jakarta. After synchronized, malarial culture was divided intoÂ 4 groups namely Control group (culture medium only), Chloroquine group, Artemisinin group, and Neem seeds extracts group. EachÂ treatment group was devided into 5 drug doses of 6.25 Âµ/ml, 12.5 Âµ/ml, 25 Âµ/ml, 50 Âµ/ml and 100 Âµ/ml respectively. Parasitemia wasÂ measured by Pyridine-hemochrome methods using spectrophotometer Â Î»560 nm. Statistical analysis was done involving one-way-ANOVA followed by Tukey HSD and Pearsonâ€™s Correlation. A significant difference was found between control and treatment groupsÂ in parasitemia and hemozoin level. Different dose in treatment groups didnâ€™t show any significant difference in both parasitemiaÂ (p=0.99) and hemozoin level (p=0.985). Tukey test between treatment groups didnâ€™t show a significant difference decrease ofÂ hemazoin level and parasitemia (r=0.970). The conclusion was Neem deeds extract can inhibit P. falciparum growth by decreasingÂ parasitemia and hemazoin level.Â Key words: Neem seeds extract, parasitemia, hemazoin level, P. falciparum
EFEK EKSTRAK BUNGA KENANGA (Canangium odoratum) SEBAGAI AGONIS PADA RESEPTOR ADRENERGIK-Î² Î²Î² Î²DI PARU TERPISAH MARMUT (Cavia porcellus)
Authors: Charisti Pherenice , Loekito Retno M , Karyono Setyawati S 
Published: January 2017

The cananga flower (Canangium odoratum) is one of the herbal medicine used for asthma bronchiale. Cananga extract have beenÂ proved to relax the isolated guinea pigâ€™s tracheal Â and bronchus smooth muscle. The relaxation of the tracheal smooth muscle couldÂ be inhibited by propanolol 10-9M, however propanolol 10-9M could not inhibit the relaxation of the bronchialsmooth muscle. ThereforeÂ the objective of this study is to investigate the effect of cananga extract on relaxation of isolated Â guinea pigâ€™s lung strip through Â Î²-adrenergic receptor. Three different dose of propranolol was used as Â Î²-adrenergic receptor antagonist. This study was anÂ experimental research using guinea pigâ€™s isolated lung strip. The control group was given histamine and cananga extract. The firstÂ group of treatment was administrated histamine, propanolol 10-9M and cananga extract. The second group of treatment was givenÂ histamine, propanolol 10-8M and cananga extract. The third group of treatmentwas given histamine, propanolol 10-7M and canangaÂ extract. The results of this study showed that cananga extract caused relaxation of lung strip and there was a reduction in theÂ relaxation of lung strip after administration of propanolol. The reduction in relaxation lung strip caused by propranolol inhibition wasÂ found to be significant using regression testing. In conclusion, cananga extract works as a partial agonist to Î²-adrenergic receptors inÂ bronchial smooth muscle of guinea pigs since the dosage response curve showed shift to the right but it was not paralel.Â Keyword :cananga extract, relaxation of lung strip, Î²-adrenergic receptor.
LUAS DEFEK MENINGOKEL BERHUBUNGAN DENGAN KADAR TRANSFORMING GROWTH FACTOR Î²1 (TGF-Î²1)DAN INSULINE-LIKE GROWTH FACTOR-1 (IGF-1) DALAM TULANG
Authors: E.S. Moch. Istiadjid 
Published: January 2017

Meningocele pathogenesis is based on skull defect that occurs since the first three month of fertilization period. Through that defect,Â mening, cerebrospinal liquid, and cerebral parenchym is protruded. Meningocele can cause by folic aciddeficiency that had provedÂ correlation with TGF-Î²1 and IGF-I level, both in maternal blood or baby ratâ€™s skull. Folic acid deficiency also causes increasing theÂ number of apoptosis and necrosis cells death in babyâ€™s skull. TGF-Î²1 and IGF-I one growth factors thatstimulate bone synthesis. TheÂ purpose of this study is to explore the correlationbetween TGF-Î²1 and IGF-I level in skull on side defect of meningocele patients andÂ the wide of skull defect to obtain the role of the Â two growth factors in meningocele teratogenesis perspectively. Eight meningoceleÂ patients that were performed excision by standard procedure have taken a few of bone speciment on sidedefect to count TGF-Î²1 andÂ IGF-I levels with immunochemistry technic. Wide defect was determined by measuring defectâ€™s diameter, using Martin anthropometer.Â The correlation between TGF-Î²1 and IGF-I skull level and defectâ€™s wide was analyzed by SEM (structuralequation modeling) statistic.Â There was significant negative-correlation between that variable, that mean the lower of the two growth factors level is wider of skullÂ defect. TGF-Î²1: r = -0.648, p =0.009; IGF-I: r = -0.426, p =0.025.Â Key words:Meningoencephalocele, Skull defect, TGF-Î²1, IGF-I.
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SALURAN NAFAS SERANGAN AKUT ASMA DENGAN JUMLAH SEL-SEL INFLAMASI DARAH TEPI
Authors: Kusuma HMS. Chandra , Kalim Kusworini Handono , Muid Masdar 
Published: January 2017

There now exists compelling evidence of a role for Â cell-mediated immunity in the pathogenesis of asthma, but little information isÂ available as to what extent this process participates in the disease severity. The hypothesized of this reseach that the severity ofÂ acute asthma exacerbation in children is associatedwith the activation of T-lymphocytes whose products regulate, at least in part, theÂ mobilization and recruitment of eosinophyls and thereby disease severity. The aims of this research, therefore, were to compare theÂ peripheral blood T-lymphocytes from acute asthmaticand no asthmatic normal control children matched for age and sex, and toÂ attempt to correlate the percentages of T-lymphocytes in the asthmatic with the numbers of peripheral Â blood eosinophyls and withÂ disease severity. Fifty one children with acute asthma exacerbation were compared with thirty one no asthmatic, normal childrenÂ matched for age and sex. Peripheral blood CD4+ and Â CD8+ T-lymphocytes was measured using immuno histochemical staining.Â Peripheral blood eosinophils were measured using anautomated laser cytometer. Asthma exacerbation severity was assessed by aÂ symptom score and spirometri. The absolute numbers Â of eosinophils and CD4+ T-lymphocytes of the asthmatic were elevated asÂ compared to the non-asthmatic normal control, whereas the numbers of CD8+ T-lymphocyte decreased significantly.
OUTCOME SINDROM NEFROTIK PADA ANAK â€“ PENELITIAN PROSPEKTIF STUDI COHORT
Authors: Subandiyah Krisni 
Published: January 2017

Nephrotic syndrome (NS) in children is a common recurrent disease. Most of the cases are due to minimal change disease with aÂ favorable outcome. The mayority of children have minimal change disease and 90 â€“ 95% will respond to steroid therapy. Response toÂ steroid therapy carries a greater prognostic weightthan the histologic features. The aim of the studywas to describe the outcome ofÂ Nephrotic Syndrome in children and to determine risk factors for these complications. Children with NSwere admitted to PediatricÂ Department Saiful Anwar Hospital Malang, January 2000 - December 2003 evaluated prospectively for one year. Data was sought onÂ steroid responsiveness, remission, relapse rates, infection, and trombosis. Patients were classified into five categories. Including:Â relapse, infrequent relapsing (IFRNS), frequent relapsing (FRNS), steroid dependent (SDNS) and steroidresistant (SRNS). BaselineÂ age, gender, clinical manifestation and laboratory finding were used to predict category of the disease. Definition of NS, remission andÂ relapse were based on the ISKDC guidelines. Of 91 children with NS, 75 (82,4%) children had steroid sensitive nephrotic syndromeÂ (SSNS) while 16 (17,6%) children were classified SRNS. In the SSNS group 42 (56%) of children were over 6 years of age and thereÂ were 51 (68%) males and 24 (32%) females.
KEDOKTERAN EMERGENSI TANTANGAN, HARAPAN, DAN MASA DEPAN
Authors: Dradjat Respati Suryanto 
Published: January 2017

The progress of science and technology in globalization era, forcing us to make-up the quality of education and services in the fild ofÂ Emergency Medicine (EM). As one of the teaching hospital in Indonesia, Saiful Anwar Hospital â€“ Brawijaya University have developedÂ this education programe. Various challenge, and opportunity have and will be faced to reach the futureof Indonesian Medical servicesÂ to be able to compete in the era of global standardKey words:emergency, education, services
PENGARUH PEMBERIAN KAPSUL EKSTRAK GARLIK TERHADAP PERUBAHAN TEKANAN DARAH DAN JUMLAH TROMBOSIT PADA PENDERITA PREEKLAMPSI RINGAN
Authors: Irwanto Yahya , Wahyudi Imam , Soewarto Soetomo 
Published: January 2017

The objectives is to investigate the efectivity of Â extract garlic capsule compared to standart therapytoward the changes of bloodÂ presure and thrombocyt level in the mild-preeclampsy patients. This study was a single-blind randomised clinical trial. The subject ofÂ study were the mild-preeclampsy pregnant women within 20 â€“ 36 weeks of gestational age whose came to the Poli Hamil RSUD dr.Â Saiful Anwar. The subject divided into 2 groups, the treatment group received both of the standart therapy of mild-preeclampsy andÂ extract garlic capsule, while the controlling grouponly received the standart therapy of mild-preeclampsy. After 2 weeks, the bloodÂ pressure and the trombocyt count was evaluated. Thesystolic blood pressure of the treatment group wasdecrease at average ofÂ 10.12 mmHg, from 140.25 Â± 5.57 before treatment to 130.12 Â± 10.84 mmHg after treatment, while in thecontrololling group thereÂ was an increase at average of 5.56 mmHg from 140.44Â± 6.14 mmHg to 146Â±13.81 mmHg. The T Test and ANCOVA analyzingÂ showed a significant result (P value were 0.001 and0.0008).