bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Effects of Ammonia Inhalants on Strength and Power Performance in Trained Men
Authors: Bartolomei Sandro , Nigro Federico , Gubellini Luca , Semprini Gabriele , Ciacci Simone , Hoffman Jay R. , Merni Franco 
Published: September 2017

Abstract
Bartolomei, S, Nigro, F, Luca, G, Gabriele, S, Ciacci, S, Hoffman, JR, and Merni, F. Acute effects of ammonia inhalants on strength and power performance in trained men. J Strength Cond Res 32(1): 244–247, 2018—The aim of the present study was to investigate the influence of ammonia inhalants on lower body power and maximal isometric strength in trained men. Twenty experienced resistance trained men (age = 26.7 ± 3.7 years; body weight = 80.59 ± 9.0 kg; body height = 179.5 ± 5.7 cm) were tested for counter movement jump power (CMJP), maximal force, and peak rate of force development (pRFD20) expressed during an isometric midthigh pull (IMTP). Assessments were performed using either an ammonia inhalant (AI), a placebo (PL), or no inhalants (N). One-way analysis of variance (ANOVA) with repeated measures was used to compare strength and power performance between the different trials. A significant (p < 0.01) increase in pRFD20 was detected following the use of AI. No significant effects of trial were noted for CMJP and IMTP maximal force (p = 0.251 and p = 0.075, respectively). Results of the present study showed a potential ergogenic effect of AI on rate of force development (i.e., explosive force output), with a trend toward an improvement in maximal force production. The mechanism of action may be related to the stimulatory action of AI often reported by athletes as a “psyching-up” effect. The positive effect of AI on the rate of force development may represent an advantage in sports requiring high rates of force production.
Influence of the Heat Treatment Processes on the Properties of High Entropy Alloys Based on Al-Cr-Fe-Mn-Ni System
Authors: Mitrica Dumitru , Soare Vasile , Constantin Ionut , Burada Marian , Olaru Mihai T. , Badilita Viorel , Soare Victoria , Stoiciu Florentin , Popescu Gabriela , Carcea Ioan 
Published: September 2017

Abstract
In the present paper, high entropy alloys based on an aluminum-chromium-iron-manganese-nickel (Al-Cr-Fe-Mn-Ni) system were prepared by induction melting and annealed in an inert atmosphere. The resulting samples were analyzed by optical microscopy, scanning electron microscopy, and X-ray diffraction to determine the structural characteristics before and after the heat treatment process. Significant phase transformations and changes in the phase distribution were noticed after the heat treatment process. The results were discussed against the thermodynamic criteria calculations for most promising compositions. Hardness tests were provided for the selected samples to indicate the changes in the mechanical properties between various compositions and between as-cast and annealed samples. Results indicated that the heat treatment process determined a significant hardness increase in one of the studied high entropy alloys.
Oscillatory Reinstatement Enhances Declarative Memory
Authors: Javadi Amir-Homayoun , Glen James C. , Halkiopoulos Sara , Schulz Mei , Spiers Hugo J. 
Published: September 2017

Declarative memory recall is thought to involve the reinstatement of neural activity patterns that occurred previously during encoding. Consistent with this view, greater similarity between patterns of activity recorded during encoding and retrieval has been found to predict better memory performance in a number of studies. Recent models have argued that neural oscillations may be crucial to reinstatement for successful memory retrieval. However, to date, no causal evidence has been provided to support this theory, nor has the impact of oscillatory electrical brain stimulation during encoding and retrieval been assessed. To explore this we used transcranial alternating current stimulation over the left dorsolateral prefrontal cortex of human participants [n= 70, 45 females; age mean (SD) = 22.12 (2.16)] during a declarative memory task. Participants received either the same frequency during encoding and retrieval (60–60 or 90–90 Hz) or different frequencies (60–90 or 90–60 Hz). When frequencies matched there was a significant memory improvement (at both 60 and 90 Hz) relative to sham stimulation. No improvement occurred when frequencies mismatched. Our results provide support for the role of oscillatory reinstatement in memory retrieval.SIGNIFICANCE STATEMENTRecent neurobiological models of memory have argued that large-scale neural oscillations are reinstated to support successful memory retrieval. Here we used transcranial alternating current stimulation (tACS) to test these models. tACS has recently been shown to induce neural oscillations at the frequency stimulated. We stimulated over the left dorsolateral prefrontal cortex during a declarative memory task involving learning a set of words. We found that tACS applied at the same frequency during encoding and retrieval enhances memory. We also find no difference between the two applied frequencies. Thus our results are consistent with the proposal that reinstatement of neural oscillations during retrieval supports successful memory retrieval.
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia
Authors: Seo Jinsoo , Kritskiy Oleg , Watson L. Ashley , Barker Scarlett J. , Dey Dilip , Raja Waseem K. , Lin Yuan-Ta , Ko Tak , Cho Sukhee , Penney Jay , Silva M. Catarina , Sheridan Steven D. , Lucente Diane , Gusella James F. , Dickerson Bradford C. , Haggarty Stephen J. , Tsai Li-Huei 
Published: September 2017

Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated with neurodegenerative disorders, including Alzheimer's disease. Previously, we showed that replacing endogenous p35 with the noncleavable mutant p35 (Δp35) attenuated amyloidosis and improved cognitive function in a familial Alzheimer's disease mouse model. Here, to address the role of p25/Cdk5 in tauopathy, we generated double-transgenic mice by crossing mice overexpressing mutant human tau (P301S) with Δp35KImice. We observed significant reduction of phosphorylated tau and its seeding activity in the brain of double transgenic mice compared with the P301S mice. Furthermore, synaptic loss and impaired LTP at hippocampal CA3 region ofP301Smice were attenuated by blocking p25 generation. To further validate the role of p25/Cdk5 in tauopathy, we used frontotemporal dementia patient-derived induced pluripotent stem cells (iPSCs) carrying the Tau P301L mutation and generated P301L:Δp35KI isogenic iPSC lines using CRISPR/Cas9 genome editing. We created cerebral organoids from the isogenic iPSCs and found that blockade of p25 generation reduced levels of phosphorylated tau and increased expression of synaptophysin. Together, these data demonstrate a crucial role for p25/Cdk5 in mediating tau-associated pathology and suggest that inhibition of this kinase can remedy neurodegenerative processes in the presence of pathogenic tau mutation.SIGNIFICANCE STATEMENTAccumulation of p25 results in aberrant Cdk5 activation and induction of numerous pathological phenotypes, such as neuroinflammation, synaptic loss, Aβ accumulation, and tau hyperphosphorylation. However, it was not clear whether p25/Cdk5 activity is necessary for the progression of these pathological changes. We recently developed the Δp35KItransgenic mouse that is deficient in p25 generation and Cdk5 hyperactivation. In this study, we used this mouse model to elucidate the role of p25/Cdk5 in FTD mutant tau-mediated pathology. We also used a frontotemporal dementia patient-derived induced pluripotent stem cell carrying the Tau P301L mutation and generated isogenic lines in which p35 is replaced with noncleavable mutant Δp35. Our data suggest that p25/Cdk5 plays an important role in tauopathy in both mouse and human model systems.
Visual Motion Discrimination by Propagating Patterns in Primate Cerebral Cortex
Authors: Townsend Rory G. , Solomon Selina S. , Martin Paul R. , Solomon Samuel G. , Gong Pulin 
Published: September 2017

Visual stimuli can evoke waves of neural activity that propagate across the surface of visual cortical areas. The relevance of these waves for visual processing is unknown. Here, we measured the phase and amplitude of local field potentials (LFPs) in electrode array recordings from the motion-processing medial temporal (MT) area of anesthetized male marmosets. Animals viewed grating or dot-field stimuli drifting in different directions. We found that, on individual trials, the direction of LFP wave propagation is sensitive to the direction of stimulus motion. Propagating LFP patterns are also detectable in trial-averaged activity, but the trial-averaged patterns exhibit different dynamics and behaviors from those in single trials and are similar across motion directions. We show that this difference arises because stimulus-sensitive propagating patterns are present in the phase of single-trial oscillations, whereas the trial-averaged signal is dominated by additive amplitude effects. Our results demonstrate that propagating LFP patterns can represent sensory inputs at timescales relevant to visually guided behaviors and raise the possibility that propagating activity patterns serve neural information processing in area MT and other cortical areas.SIGNIFICANCE STATEMENTPropagating wave patterns are widely observed in the cortex, but their functional relevance remains unknown. We show here that visual stimuli generate propagating wave patterns in local field potentials (LFPs) in a movement-sensitive area of the primate cortex and that the propagation direction of these patterns is sensitive to stimulus motion direction. We also show that averaging LFP signals across multiple stimulus presentations (trial averaging) yields propagating patterns that capture different dynamic properties of the LFP response and show negligible direction sensitivity. Our results demonstrate that sensory stimuli can modulate propagating wave patterns reliably in the cortex. The relevant dynamics are normally masked by trial averaging, which is a conventional step in LFP signal processing.
Duration of post-operative hypocortisolism predicts sustained remission after pituitary surgery for Cushing’s disease
Authors: Bansal Prachi , Lila Anurag , Goroshi Manjunath , Jadhav Swati , Lomte Nilesh , Thakkar Kunal , Goel Atul , Shah Abhidha , Sankhe Shilpa , Goel Naina , Jaguste Neelam , Bandgar Tushar , Shah Nalini 
Published: September 2017

Purpose
Transsphenoidal surgery (TSS) is the primary treatment modality for Cushing’s disease (CD). However, the predictors of post-operative remission and recurrence remain debatable. Thus, we studied the post-operative remission and long-term recurrence rates, as well as their respective predictive factors.

Methods
A retrospective analysis of case records of 230 CD patients who underwent primary microscopic TSS at our tertiary care referral centre between 1987 and 2015 was undertaken. Demographic features, pre- and post-operative hormonal values, MRI findings, histopathological features and follow-up data were recorded. Remission and recurrence rates as well as their respective predictive factors were studied.

Results
Overall, the post-operative remission rate was 65.6% (early remission 46%; delayed remission 19.6%), while the recurrence rate was 41% at mean follow-up of 74 ± 61.1 months (12–270 months). Significantly higher early remission rates were observed in patients with microadenoma vs macroadenoma (51.7% vs 30.6%, P = 0.005) and those with unequivocal vs equivocal MRI for microadenoma (55.8% vs 38.5%, P = 0.007). Patients with invasive macroadenoma had poorer (4.5% vs 45%, P = 0.001) remission rates. Recurrence rates were higher in patients with delayed remission than those with early remission (61.5% vs 30.8%, P = 0.001). Duration of post-operative hypocortisolemia ≥13 months predicted sustained remission with 100% specificity and 46.4% sensitivity. Recurrence could be detected significantly earlier (27.7 vs 69.2 months, P < 0.001) in patients with available serial follow-up biochemistry as compared to those with infrequent follow-up after remission.

Conclusion
In our study, remission and recurrence rates were similar to that of reported literature, but proportion of delayed remission was relatively higher. Negative/equivocal MRI findings and presence of macroadenoma, especially those with cavernous sinus invasion were predictors of poor remission rates. In addition to early remission, longer duration of post-operative hypocortisolism is an important predictor of sustained remission. Regular biochemical surveillance may help in identifying recurrence early.
Antioxidative potential of two chemically characterized Ocimum (Tulsi) species extracts
Authors: Agarwal Karishma , Singh Dhananjay Kumar , Jyotshna Jyotshna , Ahmad Ateeque , Shanker Karuna , Tandon Sudeep , Luqman Suaib 
Published: September 2017

Background: Ocimum sanctum and Ocimum kilimandscharicum are cultivated in Indian subcontinent both for the religious and medicinal properties. Traditionally, the leaves have been reported for their enormous therapeutic potentials but the roots which are otherwise considered as a waste part have not been explored for their pharmacological activity.
Methods: Total phenolic content, free radical scavenging and ferric reducing antioxidant potential of various extracts from Ocimum sanctum and Ocimum kilimandscharicum were assessed and compared. In vitro antioxidant activity was estimated spectrophotometrically and the most potent ethyl acetate extract was chemically characterized by developing the chemical fingerprint and quantifying the probable constituents with the help of HPLC/LC-MS techniques.
Results: The ethyl acetate extract of both the species exhibited significant free radical scavenging potential and also reduced the ferric ions. It was observed that ethyl acetate extract have superior ferric reducing potential than other tested extracts, which were evidenced by high ferrous sulphate equivalent value of 77.05 ± 1.54 and 80.98 ± 0.80 at 100 µg/ml for O. sanctum and O. kilimandscharium respectively. The ferric reducing capacity of ethyl acetate extract for both the species was also evidenced by an elevated optical density of 1.64 ± 0.12 and 2.14 ± 0.08. Ocimum sanctum exhibited better antioxidant capacity (11.31 ± 0.20 AScE) as compared to Ocimum kilimandscharium (9.08 ± 0.27 AScE). The total phenolic and flavonoid content were estimated by spectrophotometric method and tentatively characterized by HPLC/LC-MS profiling which revealed the presence of rosmarinic acid, caffeic acid along with its derivatives such as caffeoyl-dihydroxyphenyllactoyl-tartaric acid.
Conclusion: The ethyl acetate extract of both the species being rich in phenolic and flavonoid contents exhibited potent antioxidant activity. The presence of flavonoid in ethyl acetate extracts further co-relates the antioxidative properties of roots extracts. To the best of our knowledge and understanding this is the first report of comparative chemical profiling by RP-HPLC/LC-MS and antioxidant potential of roots of two Ocimum species.
Peer Review Details

Peer review method: Single-Blind (Peer-reviewers: 02) Peer-review policy
Plagiarism software screening?: Yes
Date of Original Submission: 27 July 2017
Date accepted: 23 August 2017
Peer reviewers approved by: Dr. Lili Hami
Editor who approved publication: Dr. Phuc Van Pham
Dos livros didáticos aos protótipos de ensino: em direção a um web-currículo
Authors: Marsaro-Pavan Fabiana 
Published: September 2017

Embora o desenvolvimento e a popularização das Tecnologias Digitais da Comunicação e da Informação (TIDC) as estejam aproximado cada vez mais da sala de aula, não podemos negar que elas ainda estão longe de integrar efetivamente o cotidiano escolar. Mesmo que nossa realidade seja cada vez mais on-line, digital, multissemiótica e plural, o que tem nos levado a questionar até mesmo o papel (e o futuro) da escola, os materiais mais tradicionais como livros didáticos, apostilados e sequências didática continuam a circular, ainda que por vezes disputem espaço com computadores, tablets, Objetos Digitais de Aprendizagem (ODA) e Objetos Educacionais Digitais (OED), geralmente em iniciativas bastante difusas, irregulares e desencontradas. Levando em conta que, em um contexto de novos multiletramentos (ROJO, no prelo), torna-se cada vez mais necessário estudar dispositivos didáticos que sejam capazes de atender mais satisfatoriamente às demandas atuais, no espaço disponível neste artigo buscaremos estabelecer um breve panorama do status atual dos materiais didáticos que têm circulado na escola brasileira, procurando identificar as características e fragilidades que fazem com que eles nos pareçam cada vez menos adequados para concretizar o que Almeida (2014) convencionou chamar de web-currículos.
Editorial English
Authors: Santos Gildenir Carolino 
Published: September 2017

With great satisfaction, we are opening 2010 year with this special issue, "Psychoanalysis and Philosophy: possible dialog?” with 15 studies: five articles, nine dossier texts and one experience report. Here we are addressing the representativity of two areas of the knowledge field: psychoanalysis and philosophy. In the dialogues outlined in this special issue, several authors have brought their contributions from different places and countries: Uruguay, Brazil and England. With this, we could devise an opening cover for the journal representing psychoanalysts and philosophers of the involved areas, discussed in several papers in this number: Jacques Lacan, Sigmund Freud, Michel Foucault, Gilles Deleuze and Friedrich Niestche, as a link among these authors in this puzzle.
Analisis Pesan Dakwah dalam Novellet â€œKetika Mas Gagah Pergiâ€™ Karya Helvy Tiana Rosa
Authors: Fitriyah Diah Hikmah , Lubis Zulkifli , Mardhiah Izzatul 
Published: September 2017

The development of the present age experiencing such a big challenge that is crisis morality (moral decadence) as well as social damage. Resulting in a shift in values both religious and social values. This is due to the mass media. Therefore, This research was conducted to examine the contents of messages submitted media to the public, so that people are not trapped by the contents of rhetoric contained in the mass media. This research uses discourse analysis of Teun A. Van Dijk type to know the discourse of moral messages contained in the novel "Ketika Mas Gagah Pergi" and want to know the forms of moral messages contained in the novel.
Keywords: Discourse Analysis, Moral Message, Ketika Mas Gagah Pergi
Abstrak
Perkembangan zaman saat ini mengalami tantangan yang begitu besar yakni krisisnya moralitas (dekadensi moral) serta kerusakan sosial. Sehingga terjadinya pergeseran nilai-nilai baik nilai-nilai agama maupun sosial. Hal ini disebabkan merebaknya media massa. Oleh karena itu, Penelitian ini dilakukan untuk mengkaji isi pesan yang disampaikan media kepada masyarakat, agar masyarakat tidak terjebak oleh isi retorika yang terdapat dalam media massa tersebut. Penelitian ini menggunakan analisis wacana model Teun A. Van Dijk untuk mengetahui wacana pesan akhlak yang terdapat dalam novellet â€œKetika Mas Gagah Pergiâ€ serta ingin mengetahui bentuk-bentuk pesan akhlak yang terdapat dalam novellet tersebut.
Kata Kunci: Analisis Wacana, Pesan Akhlak, Ketika Mas Gagah Pergi.
Dakwah Interkultural di Australia
Authors: Narulita Sari 
Published: September 2017

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisa proses dakwah interkultural di Australia. Temuan menunjukkan bahwa proses dakwah interkultural di Australia sudah berjalan cukup optimal karena memenuhi aspek kesadaran heterogenitas, pendekatan persuasif dan juga menafikan kebencian terhadap keyakinan lain. Terlepas dakwah Islam yang ada di Australia lebih cenderung bersifat komunitas, namun hal tersebut tidak menghalangi komunitas lain untuk terlibat di dalamnya.
Kata Kunci: Dakwah Interkultural, Heterogenitas, Australia
Nilai-Nilai Karakter dalam Kitab Al-Akhlaq Lil Banin Karya Syekh Umar Baradja
Authors: Cahya Fajar Septian , Bahri Saiful , Hayaturrohman Hayaturrohman 
Published: September 2017

This study aimed to examine the values of character education in the book al-akhlaq lil banin, Kitab al-akhlaq lil banin gives a moral message in the form of a story or the story of the man to do good, people or readers are invited to watch the character education of young children and help instill character values to become a man of character and self berjati. This study concluded that the Values Character is very important to be imparted to children younger generations are characterized by religious, Pancasila, culture, and national education goals. The author also introduces the book AlAkhlaq Lil Banin is set in Islam, so this thesis with the title of Values Character In the book Al-Akhlaq Lil Banin of Sheikh Umar Baradja.
Keywords: Character Education, Al-Akhlak Lil Banin, Value.
Abstrak
Penelitian ini bertujuan untuk menelaah nilai-nilai pendidikan karakter dalam kitab al-akhlaq lil banin, kitab al-akhlaq lil banin memberikan pesan moral dengan bentuk cerita atau kisah kepada manusia untuk berbuat baik, masyarakat atau pembaca diajak untuk memerhatikan pendidikan karakter anak-anak muda dan membantu menanamkan nilai-nilai karakter agar menjadi manusia berkarakter dan berjati diri. Penelitian ini menyimpulkan bahwa Nilai-Nilai Karakter sangat penting untuk ditanamkan kepada anak-anak generasi muda yang berkarakter berdasarkan agama, pancasila, budaya, serta tujuan pendidikan nasional. Penulis juga mengenalkan kitab Al-Akhlaq Lil Banin yang berlatarkan islam, sehingga menentukan skripsi ini dengan judul Nilai-Nilai Karakter Dalam Kitab AlAkhlaq Lil Banin karya Syekh Umar Baradja.
Kata Kunci : Pendidikan Karakter, Al-Akhlaq Lil Banin, Nilai.
Abrogasi dalam Alquran: Studi Nasikh dan Mansukh
Authors: Malik Abdul Rahman 
Published: September 2017

This article is about a central theme in the study of Ulumul Qur'an, Nasikh and Mansukh. The Urgency of this studies is to know the dynamics of a law in holly Qurâ€™an. This study use literature study Approach. The conculsion of this study is Nasakh only occurs on the command (amr) and the prohibition (nahyi), whether expressly expressed and clearly expressed by the sentence of the message intended to command or prohibition (khabar bi maâ€™na al amr awal nahy), as long as it is not related to aqidah, the substance of God and the attributes of God, in The holly Qurâ€™an, the apostles, the hereaftre, and also not related to ethics or morals or with the subjects of worship and muamalat.
Keywords: Nasikh and Mansukh, Amr and Nahy, Ulumul Qurâ€™an
Abstrak
Artikel ini hendak mengulas sebuah tema pokok dalam kajian Ulumul Qurâ€™an yakni Nasikh dan Mansukh. Urgensi kajian Nasikh dan Mansukh untuk mengetahui dinamika suatu hukum. Pendekatan yang dilakukan adalah denga studi pustaka. Studi terkait Nasikh dan Mansukh memberikan kesimpulan bahwa Nasakh hanya terjadi pada perintah (amr) dan larangan (nahyi), baik yang diungkapkan dengan tegas dan jelas maupun yang diungkapkan dengan kalimat berita yang bermaksud perintah atau larangan (khabar bi maâ€™na al amr awal nahy), selama tidak berhubungan dengan akidah, zat Allah dan sifat-sifat Allah, kitab-kitab Allah, para Rasul, hari kiamat, dan juga tidak terkait dengan etika atau akhlak atau dengan pokok-pokok ibadah dan muamalat.
Kata Kunci: Nasikh dan Mansukh Amr dan Nahyi, Ulumul Qurâ€™an