bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniform hazard floor acceleration spectra for linear structures
Authors: Lucchini Andrea , Franchin Paolo , Mollaioli Fabrizio 
Published: December 2016

SummaryThis paper presents a practical method to compute uniform hazard floor acceleration spectra for linear oscillators attached to a linear structure. The method builds on a probabilistic seismic demand model that relates the acceleration response of the oscillator with that of the generic mode of vibration of the supporting structure. Interaction between oscillator and structure is ignored. Independency of the model on the specific characteristics of seismic hazard at the site is shown. By using the method floor spectra are determined through a closed‐form expression, given the mean annual frequency of interest, the damping ratio of the oscillators, the modal properties of the structure, and three uniform hazard spectra representing seismic hazard at the site. Copyright © 2016 John Wiley & Sons, Ltd.
Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats
Authors: Li Yaru , Yu Peng , Chang Shi‐Yang , Wu Qiong , Yu Panpan , Xie Congcong , Wu Wenyue , Zhao Baolu , Gao Guofen , Chang Yan‐Zhong 
Published: December 2016

ABSTRACTDisruption of iron homeostasis in brain has been found to be closely involved in several neurodegenerative diseases. Recent studies have reported that appropriate intermittent hypobaric hypoxia played a protective role in brain injury caused by acute hypoxia. However, the mechanisms of this protective effect have not been fully understood. In this study, Sprague‐Dawley (SD) rat models were developed by hypobaric hypoxia treatment in an altitude chamber, and the iron level and iron related protein levels were determined in rat brain after 4 weeks of treatment. We found that the iron levels significantly decreased in the cortex and hippocampus of rat brain as compared to that of the control rats without hypobaric hypoxia treatment. The expression levels of iron storage protein L‐ferritin and iron transport proteins, including transferrin receptor‐1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin1 (FPN1), were also altered. Further studies found that the iron regulatory protein 2 (IRP2) played a dominant regulatory role in the changes of iron hemostasis, whereas iron regulatory protein 1 (IRP1) mainly acted as cis‐aconitase. These results, for the first time, showed the alteration of iron metabolism during hypobaric hypoxia in rat models, which link the potential neuroprotective role of hypobaric hypoxia treatment to the decreased iron level in brain. This may provide insight into the treatment of iron‐overloaded neurodegenerative diseases. J. Cell. Biochem. 118: 1596–1605, 2017. © 2016 Wiley Periodicals, Inc.
Population Pharmacokinetics of Ceritinib in Adult Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase
Authors: Hong Ying , Passos Vanessa Q. , Huang Pai‐Hsi , Lau Yvonne Y. 
Published: December 2016

AbstractCeritinib is a second‐generation selective and potent oral anaplastic lymphoma kinase (ALK) inhibitor approved for ALK‐positive advanced non–small cell lung cancer previously treated with crizotinib. Population pharmacokinetic (PK) analysis was performed to describe the PK of ceritinib and was used to evaluate the covariate effects on systemic exposure at its label dose (750 mg orally once daily). Ceritinib concentration–time data from 4 clinical studies were described by a 1‐compartment model with delayed first‐order absorption and time‐dependent elimination. The apparent clearance at steady state (CL/Fss) was determined to increase with body weight and albumin but decrease with an increase in alanine aminotransferase. Japanese ethnicity appeared to significantly influence the apparent fractional turnover rate of the inhibited metabolic enzyme (kout). No dose adjustment was necessary in patients with lower body weight or with preexisting mild hepatic impairment. The ceritinib steady‐state exposure (AUCss) at 750 mg increased by 8% (90% prediction interval [PI], 2–16) in non‐Japanese Asians and 31% (90%PI, 17–44) in Japanese patients compared with that in white patients. Other covariates including sex, age, baseline Eastern Cooperative Oncology Group performance status, baseline total bilirubin, baseline estimated glomerular filtration rate, prior crizotinib treatment, and concomitant use of proton pump inhibitors had no statistically significant effect on ceritinib PK parameters. In conclusion, the nonlinear PK of ceritinib was described using a population‐based approach in patients with ALK‐positive tumors. None of the covariates assessed in this study were considered clinically relevant and therefore do not warrant dose adjustment.
Unexpected effect of the vehicle (grain ethanol) of homeopathic FSH on the in vitro survival and development of isolated ovine preantral follicles
Authors: Lima Lartiza F. , Rocha Rebeca M. P. , Duarte Ana Beatriz G. , Brito Ivina R. , Silva Gerlane M. , Rodrigues Giovanna Q. , Nunes‐Pinheiro Diana C. S. , Sales Antônia D. , Moura Arlindo A. , Wheeler Matthew B. , Rodrigues Ana Paula R. , Campello Cláudio C. , Figueiredo José Ricardo 
Published: December 2016

AbstractThe aims of this study were to investigate the effects of medium replacement system (experiment I) and of FSH presentations (homeopathic – FSH 6cH and allopathic FSH – rFSH; experiment II) on the in vitro development, hormone production and gene expression of isolated ovine preantral follicles cultured for 6 days. In experiment I, secondary follicles were cultured in the α‐MEM+ supplemented with FSH 6cH (0.05 fg/ml) or recombinant bovine FSH (100 ng/ml) without/with daily medium addition. The homeopathic FSH treatments with/without medium addition improved (p < .05) follicular development compared to rFSH100 treatment without addition. FSH 6cH with addition showed the highest (p < .05) estradiol production. To verify whether the effects of homeopathic FSH were not due to its vehicle, experiment II was performed. The α‐MEM+ was supplemented or not with alcohol (0.2% grain ethanol, v/v), FSH 6cH or rFSH100 with daily medium addition. Surprisingly, we found that all treatments improved follicular development compared to the α‐MEM+ (p < .05). Moreover, homeopathic FSH was similar to the other treatments including its vehicle. In conclusion, its vehicle (ethanol) causes the effect of homeopathic FSH on in vitro development of isolated ovine preantral follicles.
Fabrication and Physical Properties of Poly(ε‐Caprolactone)/Modified Graphene Nanocomposite
Authors: Hua Lei , Chen Qixian , Yin Jing , Zhang Chunqiu , Wang Xiaoli , Yin Jiandao , Feng Xin , Yang Jinjun 
Published: December 2016

A chemical strategy is attempted to modify graphene for its facilitated dispersion in poly(ε‐caprolactone) (PCL) matrix. Herein, graphite oxide is subjected to sequential treatment with phenyl isocyanate and vitamin C (VC) to yield graphene nanosheets (iG‐VC). It is noteworthy that following the reduction treatment, iG‐VC graphene sheets exfoliate within the PCL matrix and show appreciable interfacial compatibility with PCL matrix in organic solvent by virtue of improved polarity from isocyanate treatment. The tensile yield strength and Young's modulus of the PCL/iG‐VC composite exhibit pronounced enhancement as compared to neat PCL, despite of mere composition of graphene sheets. The tensile yield stress of composite is increased notably to reach 18.6 MPa at 3 wt% graphene sheets as compared to neat PCL. Likewise, Young's modulus of composite is observed to increase from 370 to 470 MPa at 5 wt% graphene sheets. Moreover, the crystallization temperature (Tc) and crystallinity of PCL increase significantly upon incorporation of small amount of iG‐VC. Ultimately, functional role of iG‐VC graphene sheets is demonstrated in enhancing electrical conductivity of PCL‐based nanocomposites. The plausible mechanisms are also proposed to explain the increasedTc, improved mechanical property, and improved electrical conductivity of PCL/iG‐VC composite.image
UV‐Patterning of Anti‐Biofouling Zwitterionic Copolymer Layer with an Aromatic Anchor Group
Authors: Li Lifu , Nakaji‐Hirabayashi Tadashi , Tokuwa Ken‐ichi , Kitano Hiromi , Ohno Kohji , Usui Yuki , Kishioka Takahiro 
Published: December 2016

A thin layer (around 2 nm in thickness) composed of a random copolymer of zwitterionic carboxymethyl betaine (CMB) and p‐trimethoxysilylstyrene (STMS) (9:1) is constructed on a glass substrate or a silicon wafer. The copolymer layer is highly resistant against nonspecific adsorption of bovine serum albumin (BSA). However, on UV irradiation at 193 nm, the layer becomes hydrophobic and BSA is significantly adsorbed on the substrate. Upon UV irradiation through a photomask, a patterning of the fluorophore‐labeled protein with a resolution of about 1 µm can be clearly observed. On the other hand, the copolymer layer of CMB and 3‐methacryloxypropyltrimethoxysilane (MPTMS) (9:1) without an aromatic group exhibit less distinct pattern. Further, the poly(CMB‐r‐STMS) layer decomposes more quickly compared with the poly(CMB‐r‐MPTMS) layer at low irradiation dose. The zwitterionic polymer layer with an aromatic anchor group will be used at the modification of substrates applicable to sensing devices.
image
Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8‐prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay
Authors: Costa Raquel , Rodrigues Ilda , Guardão Luísa , Lima Joana Quelhas , Sousa Emília , Soares Raquel , Negrão Rita 
Published: December 2016

ScopeImbalance in kidney and heart neovascularization is common in type2 diabetes (T2DM) patients. Nevertheless, the mechanisms governing this angiogenic paradox have not been elucidated. Xanthohumol (XN) and 8‐prenylnaringenin (8PN) beer polyphenols modulate angiogenesis, being thus targets for T2DM‐related complications. Our work examined whether polyphenols consumption affects angiogenic paradox and metabolism in a T2DM mouse model.Methods and resultsAn increase in kidney and a reduction in left ventricle (LV) microvessels of diabetic C57Bl/6 mice were observed. XN consumption reduced angiogenesis, VEGFR‐2 expression/activity, VEGF‐A and phosphofructokinase‐2/fructose‐2,6‐bisphosphatase‐3 enzyme expression, a metabolic marker present in endothelial tip cells in T2DM mice kidney. 8PN had opposite effects in T2DM mice LV. These XN and 8PN effects were dependent on VEGF levels as revealed by in vitro assays. These findings were accompanied by tissue and plasma reduced expression levels of VEGF‐B and its receptors, VEGFR1 and neuropilin‐1, by both polyphenols.ConclusionBeer polyphenols modulate T2DM angiogenic paradox in a tissue‐dependent manner. We also show for the first time that both polyphenols decreased VEGF‐B pathway, which is implicated in endothelial‐to‐tissue lipid metabolism. Altogether, the effects of these polyphenols in the crosstalk between angiogenesis and metabolism render them potent agents for novel diabetic therapeutic interventions.
Consumption of the total Western diet differentially affects the response to green tea in rodent models of chronic disease compared to the AIN93G diet
Authors: Ward Robert E. , Benninghoff Abby D. , Healy Brett J. , Li Minghao , Vagu Bharath , Hintze Korry J. 
Published: December 2016

ScopeIn pre‐clinical studies investigating bioactive components, the efficacy of the bioactive is likely influenced by the basal diet provided to rodents. In this study, we hypothesized that a model bioactive, green tea extract (GTE), would have different effects on colon carcinogenesis, body composition, and lipid metabolism in mice fed a basal diet formulated to promote animal health and growth (AIN93G) as compared to a Western diet that emulates typical American intakes of micro‐ and macronutrients, the total Western diet (TWD).Methods and resultsMice were fed either AIN93G or TWD, with or without GTE added to drinking water for 18 weeks. Aberrant crypt foci (ACF) in azoxymethane‐initiated mice was nearly three times greater in mice fed TWD compared to AIN93G. Consumption of GTE suppressed ACF development only in mice fed the TWD. Similarly, supplementation with GTE suppressed weight gain and fasted glucose only in mice fed TWD, while GTE suppressed fat mass in mice fed either diet. Irrespective of diet, GTE supplementation increased cecum weight and decreased cecal SCFA concentration.ConclusionCollectively, these observations indicate that the TWD influences the bioactivity of GTE in rodent models of obesity, metabolism, and carcinogenesis.
A woven fabric for interconnecting back‐contact solar cells
Authors: Borgers Tom , Govaerts Jonathan , Voroshazi Eszter , Jambaldinni Shruti , O'Sullivan Barry , Singh Sukhvinder , Debucquoy Maarten , Szlufcik Jozef , Poortmans Jef 
Published: December 2016

AbstractThis paper reports on a novel and highly innovative technology to interconnect back‐contact cells. First, a background section explains the currently developed interconnection technologies. Then, our novel concept is introduced: interconnection of the cells is achieved with a woven fabric, combining both conductive wires, needed for the interconnection, and insulating wires, crucial to avoid shunting between both polarities at the backside of the cell. Weaving also allows out‐of‐plane stress relief features. In the third section, we explain that our technology combines the advantages of multi‐wire interconnection such as low‐stress and reduced resistive losses with known and low‐cost materials of traditional module assembly. Additional to previous publications, we demonstrate that the technology can be tuned broadly in terms of costs and resistive losses using an optimized interconnection pattern. These resistive loss simulations are also validated with the measured additional resistance in IBC test samples. We also present a preliminary thermal cycling test with promising results. Finally, first functional demonstrators IBC cells are fabricated, disclosing the process flow and initial technology developments. These results clearly demonstrate the proof‐of‐concept of the woven interconnection fabric, and based on electrical characterization we provide suggestions for improvements. Copyright © 2016 John Wiley & Sons, Ltd.
Factors contributing to lifelong science learning: Amateur astronomers and birders
Authors: Jones M. Gail , Corin Elysa Nicole , Andre Thomas , Childers Gina M. , Stevens Vanessa 
Published: December 2016

AbstractThis research examined lifelong science learning reported by amateur astronomers and birders. One hundred seven adults who reported engaging in an informal (out‐of‐school) science interest were interviewed as part of an ongoing series of studies of lifelong science learners. The goal of the study was to gain insight into how and why amateur astronomers and birders pursue their hobby, how their hobby developed, and what influenced that development. Educators may use this information to design programs that support informal science learning over the lifespan. Informed by self‐determination theory, the characteristics, initial experiences, and interests, influences on continued development of science interests, sources of education, and benefits of engaging in a science hobby were explored. Results showed that most of the participants’ lifelong science interests began in childhood and were influenced by events, resources, and family members. Members of both hobby groups reported that, as a result of their informal science interests, they were more knowledgeable about science, more knowledgeable about how science is done, possessed better observation skills, possessed more environmental awareness, and had opportunities to socialize and network with others with similar interests. The intersection of motivation and social capital derived from hobby engagement and lifelong science learning is discussed. © 2016 Wiley Periodicals, Inc. J Res Sci Teach 54: 412–433, 2017
Do teaching assistants matter? Investigating relationships between teaching assistants and student outcomes in undergraduate science laboratory classes
Authors: Wheeler Lindsay B. , Maeng Jennifer L. , Chiu Jennie L. , Bell Randy L. 
Published: December 2016

AbstractThis study explores the relationship between teaching assistants (TAs) and student learning in undergraduate science laboratory classes. TAs typically instruct laboratory courses, yet little, if any, research examines professional development (PD) for TAs or relationships between instructors and students in laboratory settings. The use of undergraduate TAs (UTAs) in the same manner as graduate TAs (GTAs) in inquiry‐based lab settings has yet to be explored. This quantitative study explored how TAs’ content knowledge, beliefs about teaching, and teaching confidence change as a result of PD and how TAs’ prior experience, UTA/GTA status, content knowledge, beliefs, and teaching confidence relates to students’ content knowledge learning in an inquiry‐based general chemistry laboratory. Participants included 14 GTAs, 5 UTAs, and their 529 students at a public university. PD supported TAs to lead inquiry‐based general chemistry laboratory classes, involving a week‐long workshop and 14 weekly follow‐up meetings. Results demonstrate that TAs’ content knowledge improved following PD and teaching, t(18) = −3.62, p = 0.002, and students’ content knowledge significantly improved across the semester, t(528) = −36.27, p = 0.000, dCohen = 1.3. Further, TAs with higher content knowledge post‐PD tended to have students with higher end‐of‐semester content (r = 0.517, p = 0.000). No differences existed between UTAs or GTAs on any TA characteristic or student outcome measure. Using a hierarchical linear regression model, student post‐semester content knowledge was predicted by student demographics; however, no TA characteristics or demographics were significant predictors of student content knowledge. Students who perceived their TA as more supportive also believed they learned more content (r = 0.280, p =0.000). Thus, UTAs can be used in lieu of GTAs in our inquiry‐based general chemistry laboratory context and could be a possible alternative for TA instructors at other universities. Continued work examining TA PD, TA characteristics, TA practice, and student learning in inquiry‐based laboratory contexts is warranted. © 2016 Wiley Periodicals, Inc. J Res Sci Teach 54: 463–492, 2017
Sexual Sensation Seeking, Sexual Compulsivity, and Gender Identity and Its Relationship with Sexual Functioning in a Population Sample of Men and Women
Authors: Burri Andrea 
Published: December 2016

Abstract

Introduction
Despite awareness of the importance of psycho-affective factors in the development of sexual problems, there is a lack of studies exploring the relation of sexual sensation seeking (SSS) and sexual compulsivity (SC) to sexual functioning. Because sex differences in SSS and SC have been reported, gender identity (GI; an individual’s own experience of his or her gender that is unrelated to the actual biological sex) might act as a moderator in this relation.

Aim
To understand the role of SSS and SC for men and women's sexual functioning and to explore whether these potential associations are moderated by GI.

Methods
A population-based cross-sectional online survey targeted 279 individuals (69.2% women, 30.8% men; mean age = 32 years). Validated questionnaires, including the Sexual Sensation Seeking Scale, the Sexual Compulsivity Scale, the Female Sexual Function Index, the Premature Ejaculation Diagnostic Tool, and the International Index of Erectile Function, were applied.

Main Outcome Measures
Variations in SSS and SC and their association with sexual functioning were investigated using Spearman rank correlation. Moderation analyses were conducted using regression models in which the interaction terms between SSS and GI and between SCS and GI as predictors of sexual functioning were included.

Results
A statistically significant correlation between SSS and SC could be detected in men and women (r = 0.41 and 0.33, respectively; P &lt; .001 for the two comparisons). In women, higher levels of SSS were associated with higher levels of desire, arousal, lubrication, and orgasm and less sexual pain (P &lt; .05 for all comparisons). No moderating effect of GI could be detected. In men, GI was a significant moderator in the relation between SC and erectile function (β = 0.47; P &lt; .001) and between SSS and erectile and ejaculatory function (β = −0.41 and 0.30; P &lt; .001 for the two comparisons).

Conclusion
The present study is the first to show a link between SSS and SC and sexual functioning. The results might have important clinical implications and can provide useful information for programs aimed at sexual health enhancement.
Exercise induced hypoalgesia is elicited by isometric, but not aerobic exercise in individuals with chronic whiplash associated disorders
Authors: Smith Ashley , Ritchie Carrie , Pedler Ashley , McCamley Kaitlin , Roberts Kathryn , Sterling Michele 
Published: December 2016

Abstract

Background and aims
Reduced pain sensitivity following exercise is termed exercise induced hypoalgesia (EIH). Preliminary evidence suggests that impairment of EIH is evident in individuals with whiplash associated disorders (WAD) following submaximal aerobic exercise. This study aimed to compare EIH responses to isometric and aerobic exercise in patients with chronic WAD and healthy controls and investigate relationships between EIH, conditioned pain modulation (CPM) and psychological factors in patients with chronic WAD.

Methods
A cross sectional pre-post study investigated the effect of a single session of submaximal aerobic cycling exercise and a single session of isometric timed wall squat exercise on EIH in a group of participants with chronic WAD (n = 21) and a group of asymptomatic control participants (n = 19). Bivariate analyses between EIH and baseline measures of CPM and psychological features (fear of movement, pain catastrophization and posttraumatic stress symptoms) were also investigated.

Results
The isometric wall squat exercise but not the aerobic cycling exercise resulted in EIH in both groups (P < .023) with no between-group differences (P > .55) demonstrated for either exercise. There were no significant associations measured between EIH (for either exercise performed), and CPM, or any of the psychological variables.

Conclusions
This study showed that individuals with chronic WAD and mild to moderate pain and disability, and no evidence of dysfunctional CPM, demonstrated reduced pain sensitivity, both in the cervical spine and over the tibialis anterior following an isometric, timed wall squat exercise. Cycling exercise did not increase pain sensitivity.

Implications
Individuals with chronic WAD and mild to moderate levels of neck pain and disability may experience less pain sensitivity both locally and remotely following an exercise program directed at nonpainful muscles performing isometric exercises. Individuals cycling for 30 min at 75% of age-predicted heart rate maximum do not experience increased pain sensitivity.