bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive power of remote sensing versus temperature‐derived variables in modelling phenology of herbivorous insects
Authors: Pöyry Juha , Böttcher Kristin , Fronzek Stefan , Gobron Nadine , Leinonen Reima , Metsämäki Sari , Virkkala Raimo 
Published: August 2017

AbstractApplication of remote sensing datasets in modelling phenology of heterotrophic animals has received little attention. In this work, we compare the predictive power of remote sensing versus temperature‐derived variables in modelling peak flight periods of herbivorous insects, as exemplified by nocturnal moths. Moth phenology observations consisted of weekly observations of five focal moth species (Orthosia gothica,Ectropis crepuscularia,Cabera exanthemata,Dysstroma citrataandOperophtera brumata) gathered in a national moth monitoring scheme in Finland. These species were common and widespread and had peak flight periods in different seasons. Temperature‐derived data were represented by weekly accumulating growing degree days (GDD) calculated from gridded temperature observations. Remote sensing data were obtained from three sources: (1) snow melt‐off date from theMODISdaily snow maps, (2) greening date using theNDWIfromMODISdata and (3) dates of start, maximum and end of growing season based on theJRC FAPARproducts. Peak phenology observations of moths were related to different explanatory variables by using linear mixed effect models (LMM), with 70% of the data randomly selected for model calibration. Predictive power of models was tested using the remaining 30% of the data. Remote sensing data (snow melt‐off and vegetation greening date) showed the highest predictive power in two moth species flying in the early and late spring, whereas in the three other species none of the variables showed reasonable predictive power. Flight period of the spring species coincides with natural events such as snow melt or vegetation greening that can easily be observed using remote sensing techniques. We demonstrate the applicability of our methodology by predictive spatial maps of peak flight phenology covering the entire Finland for two of the focal species. The methods are applicable in situations that require spatial predictions of animal activity, such as the management of populations of insect pest species.
Developing IntegrityCatalog, a software system for managing integrity‐related metadata in digital repositories
Authors: Chondros Nikos , Roussopoulos Mema 
Published: August 2017

SummaryDigital repositories must periodically check the integrity of stored objects to assure users of their correctness. Prior solutions calculate integrity metadata and require the repository to store it alongside the actual data objects. To safeguard and detect damage to this metadata, prior solutions rely on widely visible media (unaffiliated third parties) to store and provide back digests of the metadata to verify it is intact. However, they do not address recovery of the integrity metadata in case of damage or adversarial attack. We introduce IntegrityCatalog, a novel software system that can be integrated into any digital repository. It collects all integrity‐related metadata in a single component and treats them as first class objects, managing both their integrity and their preservation. We introduce a treap‐based persistent authenticated dictionary managing arbitrary length key/value pairs, which we use to store all integrity metadata, accessible simply by object name. Additionally, IntegrityCatalog is a distributed system that includes a network protocol that manages both corruption detection and preservation of this metadata, using administrator‐selected network peers with 2 possible roles. Verifiers store and offer attestations on digests and have minimal storage requirements, while preservers efficiently synchronize a complete copy of the catalog to assist in recovery in case of a detected catalog compromise on the local system. We present our approach in developing the prototype implementation, measure its performance experimentally, and demonstrate its effectiveness in real‐world situations. We believe the implementation techniques of our open‐source IntegrityCatalog will be useful in the construction of next‐generation digital repositories.
The Transcription Factor 7-Like 2–Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation
Authors: Wanet Anaïs , Caruso Marino , Domelevo Entfellner Jean-Baka , Najar Mehdi , Fattaccioli Antoine , Demazy Catherine , Evraerts Jonathan , El-Kehdy Hoda , Pourcher Guillaume , Sokal Etienne , Arnould Thierry , Tiffin Nicki , Najimi Mustapha , Renard Patricia 
Published: August 2017

Abstract
Increasing evidence supports that modifications in the mitochondrial content, oxidative phosphorylation (OXPHOS) activity, and cell metabolism influence the fate of stem cells. However, the regulators involved in the crosstalk between mitochondria and stem cell fate remains poorly characterized. Here, we identified a transcriptional regulatory axis, composed of transcription factor 7-like 2 (TCF7L2) (a downstream effector of the Wnt/β-catenin pathway, repressed during differentiation) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) (the master regulator of mitochondrial biogenesis, induced during differentiation), coupling the loss of pluripotency and early commitment to differentiation, to the initiation of mitochondrial biogenesis and metabolic shift toward OXPHOS. PGC-1α induction during differentiation is required for both mitochondrial biogenesis and commitment to the hepatocytic lineage, and TCF7L2 repression is sufficient to increase PGC-1α expression, mitochondrial biogenesis and OXPHOS activity. We further demonstrate that OXPHOS activity is required for the differentiation toward the hepatocytic lineage, thus providing evidence that bi-directional interactions control stem cell differentiation and mitochondrial abundance and activity.
Maternal hemodynamics in normal pregnancy and in pregnancy affected by pre‐eclampsia
Authors: Stott D. , Nzelu O. , Nicolaides K. H. , Kametas N. A. 
Published: August 2017

ABSTRACTObjectivesTo determine if, in a high‐risk group of women in the first half of pregnancy, those who develop pre‐eclampsia (PE) with fetal growth restriction (FGR) demonstrate distinct hemodynamics compared with those with PE in the absence of FGR (PE only).MethodsCardiac output (CO), peripheral vascular resistance (PVR) and mean arterial pressure (MAP) were measured at the first hospital visit at 9–24 weeks' gestation in 69 women who had chronic hypertension and 67 who had had a hypertensive disorder in a previous pregnancy. These women were divided into five groups according to pregnancy outcome. In total, 19 subsequently developed PE only, 22 developed PE with FGR, 17 developed pregnancy‐induced hypertension, 39 had chronic hypertension without PE or FGR and 39 had had a hypertensive disorder in a previous pregnancy without PE, pregnancy‐induced hypertension or FGR in the index pregnancy. The hemodynamic values in each of these groups were compared with those in a cohort of 300 low‐risk women with normal pregnancy.ResultsIn all the high‐risk groups, PVR and MAP were higher than in women with a normal pregnancy, but CO was lower in the group of women with PE and FGR, whereas in the other high‐risk groups, it was not significantly different from normal.ConclusionsIn women who develop PE, there is evidence of high PVR and MAP from the first half of pregnancy, whilst PE and FGR are associated with failure in physiological expansion of CO. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Wind turbine performance decline in Sweden
Authors: Olauson Jon , Edström Per , Rydén Jesper 
Published: August 2017

AbstractWe show that Swedish wind turbines constructed before 2007 lose 0.15 capacity factor percentage points per year, corresponding to a lifetime energy loss of 6%. A gradual increase of downtime accounts for around one third of the deterioration and worsened efficiency for the remaining. Although the performance loss in Sweden is considerably smaller than previously reported in the UK, it is statistically significant and calls for a revision of the industry practice for wind energy calculations. The study is based on two partly overlapping datasets, comprising 1,100 monthly and 1,300 hourly time series spanning 5–25 years each.
Appendiceal Duplication: A Comprehensive Review of Published Cases and Clinical Recommendations
Authors: Nageswaran H. , Khan U. , Hill F. , Maw A. 
Published: August 2017

AbstractBackgroundDuplex appendix is very rare (incidence 0.004%) but has clinical relevance given the frequency of appendicectomies performed. Failure to recognise duplication can result in failure of treatment and medico‐legal consequences. A review of published cases was undertaken to identify factors that may help in managing this rare condition.MethodsAll English and non‐English publications were identified in PubMed, Embase and Cochrane databases. Patient demographics, intraoperative findings, anatomical details and histopathology were analysed.ResultsA total of 141 cases were identified [male/female ratio 1.4:1, median age 20 years (range foetus to 69 years)]. Duplication of the appendix ranges from branching of the appendix trunk to a fully matured appendix located elsewhere along the colon. Most can be categorised by the Cave–Wallbridge classification. There were 22 Type A, 8 Type B1, 46 Type B2 and 10 Type C cases (Cave–Wallbridge). There were six cases of horseshoe and two cases of triple appendix. Six reports gave anatomical descriptions that could not be classified by Cave–Wallbridge categories and in 11 cases there were no anatomical descriptions.ConclusionsAn anteriorly placed appendix, away from the convergence of the taenia, or a normal appendix in the presence of convincing clinical or radiological signs of appendicitis should instigate a careful examination of the caecal pole and possible exploration of the retrocaecal space for appendiceal duplication. If the patient had previous surgery for congenital abnormalities, Type B1 or Type C duplication should be considered.
ON THE AGGREGATION OF EXPERTS' INFORMATION IN BONUS–MALUS SYSTEMS
Authors: Blanco Víctor , Pérez-Sánchez José M. 
Published: August 2017

AbstractIn this paper, we propose a new family of premium calculation principles based on the use of prior information from different sources. Under this framework and based on the use of Ordered Weighted Averaging operators, we provide alternative collective and Bayes premiums and describe some approaches to efficiently compute them. Several examples are detailed to illustrate the performance of the new methods.
‘EVERYMAN A CAPITALIST’ OR ‘FREE TO CHOOSE’? EXPLORING THE TENSIONS WITHIN THATCHERITE INDIVIDUALISM
Authors: DAVIES ALED , FREEMAN JAMES , PEMBERTON HUGH 
Published: August 2017

AbstractIt is widely recognized that ‘the individual’ was prioritized by the Thatcher governments. However, there has been little analysis by historians of exactly how the Thatcher government conceptualized ‘the individual’. In this article, we attempt to remedy this deficiency by undertaking a case-study of a key Thatcherite social policy reform: the introduction of ‘personal pensions’. This approach allows us to understand the position of ‘the individual’ on the functional level of Thatcherite policy-making. In doing so, we argue that there was no coherent or fixed Thatcherite concept of the individual. Instead, we identify three fundamental tensions: (i) should individuals be capitalists or consumers; (ii) were they rational or irrational; and (iii) should they be risk-taking entrepreneurs or prudent savers? This reflected, in part, conflicts within the diverse tapestry of post-war neoliberal thought. We demonstrate in this article that these tensions undermined the Thatcher governments’ original attempt to create a society of entrepreneurial investor-capitalists, which in turn cemented their preference for simply maximizing individual freedom of choice within a competitive – yet tightly regulated – market environment.
CONSANGUINEOUS MARRIAGE IN JORDAN: AN UPDATE
Authors: Islam M. Mazharul , Ababneh Faisal M. , Khan MD Hasinur Rahaman 
Published: August 2017

SummaryThis study examined the recent level, trends and determinants of consanguineous marriage in Jordan using time-series data from the Jordan Population and Family Health Surveys (JPFHSs). According to the 2012 JPFHS, 35% of all marriages were consanguineous in Jordan in 2012. There has been a declining trend in consanguinity in the country, with the rate decreasing from a level of 57% in 1990. Most consanguineous marriage in 2012 were first cousin marriages, constituting 23% of all marriages and 66% of all consanguineous marriages. The data show that women with a lower age at marriage, older marriage cohort, larger family size, less than secondary level of education, rural place of residence, no employment, no exposure to mass media, a monogamous marriage, a husband with less than higher level of education and lower economic status, and those from the Badia region, were more likely to have a consanguineous marriage. Increasing age at marriage, level of education, urbanization and knowledge about the health consequences of consanguinity, and the ongoing socioeconomic and demographic transition in the country, will be the driving forces for further decline in consanguinity in Jordan.
Thawing the ice: a contemporary solution to Antarctic sovereignty
Authors: Chong Wygene 
Published: August 2017

ABSTRACTThe Antarctic Treaty System (ATS) has provided a peaceful framework for governing the continent over many decades, in spite of seven extant territorial claims. However, its method of freezing these claims has been criticised for being short-sighted and ineffective in providing a long-term solution. This paper argues to the contrary. It undertakes a brisk analysis of different categories of alternatives: global commons, absolute sovereignty, restricted sovereignty and shared sovereignty. After dismissing each category for various reasons, it promotes the reform of the existing ATS, in which a long-term vision and modified chairmanship structure provide stronger leadership and more effective implementation. Essentially, it holds that the primary reason there is criticism of the system is because it is not functioning as well as it might be. The paper not only contends that a developed ATS is an achievable aim, but that it could eventually develop into a restricted, shared sovereignty governance framework. That form of governance, which would emerge over time, could be a more durable solution that resolves the competing territorial claims. In this way, the paper charts a potential pathway for the future of Antarctic governance. This path begins, however, with a reformed ATS.
On the goods of the religious life: contextualizing the approach of Richard Swinburne
Authors: WYNN MARK 
Published: August 2017

AbstractIn this article, I seek to extend Richard Swinburne's discussion of the practical reasonableness of the religious way of life, by locating his account of the goods of that life within a larger context. Drawing on Thomas Aquinas's category of infused moral virtue, I sketch an account of the motivational lure of the religious life which supplements Swinburne's emphasis on the fulfilment of moral obligation, by considering the significance of, for example, distinctively theological aesthetic goods.
MicroRNA-34/449 targets IGFBP-3 and attenuates airway remodeling by suppressing Nur77-mediated autophagy
Authors: Yin Huiming , Zhang Shu , Sun Yahong , Li Sha , Ning Yunye , Dong Yuchao , Shang Yan , Bai Chong 
Published: August 2017

AbstractAutophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling and many factors including proinflammatory cytokines and inflammation related pathways are involved in the process. The aim of the present study was to examine the role of epithelial microRNAs (miRNAs) in autophagy-mediated airway remodeling and to identify the factors involved and the underlying mechanisms. Serum miR-34/449, inflammatory factors, and autophagy and fibrosis-related proteins were determined by real-time PCR, enzyme-linked immunosorbent assay and western blotting in 46 subjects with asthma and 10 controls and in the lung epithelial cell line BEAS-2B induced with IL-13 and treated with miRNA mimics. Luciferase assays were used to verify IGFBP-3 as a target of miR-34/449, and immunohistochemistry, immunofluorescence and co-immunoprecipitation were used in vitro and in vivo study. miR-34/449 were downregulated in patients with asthma in parallel with the upregulation of autophagy-related proteins. Proinflammatory factors and fibrosis-related proteins were significantly higher in asthma patients than in healthy controls. IL-13 induction promoted autophagy and upregulated miR-34/449 in BEAS-2B cells, and these effects were restored by IGFBP-3 silencing. miR-34/449 overexpression suppressed autophagy, decreased fibrosis, activated Akt, downregulated fibrosis-related factors, and downregulated proinflammatory cytokines and nuclear factor κB by targeting IGFBP-3. In vivo experiments showed that miR-34/449 overexpression was associated with Nur77 nuclear translocation and IGFBP-3 downregulation in parallel with decreased airway remodeling by decreased autophagy. miR-34/449 are potential biomarkers and therapeutic targets in asthma. miR-34/449 may contribute to airway inflammation and fibrosis by modulating IGFBP-3 mediated autophagy activation.
Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release
Authors: Martín-Sánchez Fátima , Martínez-García Juan José , Muñoz-García María , Martínez-Villanueva Miriam , Noguera-Velasco José A , Andreu David , Rivas Luís , Pelegrín Pablo 
Published: August 2017

AbstractThe nucleotide-binding domain and leucine-rich repeat-containing receptor with a pyrin domain 3 (NLRP3) inflammasome is a sensor for different types of infections and alterations of homeostatic parameters, including abnormally high levels of the extracellular nucleotide ATP or crystallization of different metabolites. All NLRP3 activators trigger a similar intracellular pathway, where a decrease in intracellular K+ concentration and permeabilization of plasma membrane are key steps. Cationic amphipathic antimicrobial peptides and peptide toxins permeabilize the plasma membrane. In fact, some of them have been described to activate the NLRP3 inflammasome. Among them, the bee venom antimicrobial toxin peptide melittin is known to elicit an inflammatory reaction via the NLRP3 inflammasome in response to bee venom. Our study found that melittin induces canonical NLRP3 inflammasome activation by plasma membrane permeabilization and a reduction in the intracellular K+ concentration. Following melittin treatment, the apoptosis-associated speck-like protein, an adaptor protein with a caspase recruitment domain (ASC), was necessary to activate caspase-1 and induce IL-1β release. However, cell death induced by melittin prevented the formation of large ASC aggregates, amplification of caspase-1 activation, IL-18 release and execution of pyroptosis. Therefore, melittin-induced activation of the NLRP3 inflammasome results in an attenuated inflammasome response that does not result in caspase-1 dependent cell death.
RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis
Authors: Geng Rong , Tan Xin , Wu Jiangxue , Pan Zhizhong , Yi Min , Shi Wei , Liu Ranyi , Yao Chen , Wang Gaoyuan , Lin Jiaxin , Qiu Lin , Huang Wenlin , Chen Shuai 
Published: August 2017

AbstractColorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, and so on. Ring finger domain proteins have been reported involved in carcinogenesis, whereas their roles in CRC are rarely studied. Here, we reanalyzed the expression of 202 RNF family members in CRC using published microarray data from GEO database and found that RNF183 is markedly upregulated in tumor tissues. RNF183 high expression is significantly associated with tumor size (P=0.012), tumor invasive depth (P=0.004), TNM stage (P=0.01), and distant metastasis (P=0.009). CRC patients with high expression of RNF183 have poor overall survival (P<0.001) and progression-free survival (P<0.001). Functional studies suggest that RNF183 facilitates growth, migration, and invasion of CRC cells in vitro and promotes tumor proliferation and metastasis in vivo. Mechanistically, RNF183 activates NF-κB signal pathway through P65 and stimulates the transcription of multifunctional chemokine IL-8. Blockage of NF-κB by small molecule inhibitor or depletion of IL-8 by siRNA attenuates the function of RNF183 to promote cell migration. Moreover, the regulation of RNF183 on IL-8 transcription and cell viability/motility is dependent on its E3 ubiquitin ligase activity. Our study provided proof of principle to show that RNF183 promotes proliferation and metastasis of CRC cells via activation of NF-κB-IL-8 axis.
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
Authors: Song Yong-xi , Sun Jing-xu , Zhao Jun-hua , Yang Yu-chong , Shi Jin-xin , Wu Zhong-hua , Chen Xiao-wan , Gao Peng , Miao Zhi-feng , Wang Zhen-ning 
Published: August 2017

AbstractThousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.