bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimisation of Catalytic Oxidation Conditions for the 2‐Keto‐L‐Gulonic Acid Production Using Response Surface Methodology
Authors: Mutlu Ceren , Candal‐Uslu Cihadiye , Erbaş Mustafa 
Published: September 2024

AbstractL‐Ascorbic acid, also known as vitamin C, is a very important antioxidant ingredient situated many usage areas in different industries. 2‐keto‐L‐gulonic acid (2‐KLG) is the main precursor component of L‐ascorbic acid production and it can be produced from L‐sorbose via microbial fermentation or chemical (catalytic) oxidation. While some special strains are used in microbial fermentation, it is benefitted from some catalysts in chemical oxidation. Herein, it was aimed to determine the optimum reaction temperature, pH, and time conditions to produce maximum 2‐KLG compound with the catalytic oxidation of L‐sorbose in the presence of Pt/Al2O3 catalyst with response surface methodology approach. For this aim, the reaction temperature, pH, and time used as variable factors. The limit values of variable factors were applied as 40–60 °C for the temperature, 7.00–9.00 for the pH value, and 3–9 h for the time. The analyses results demonstrated that the increasing temperature and time negatively effected the conversion of L‐sorbose into the 2‐KLG. The optimum conditions of variable factors were determined as 41.30 °C for the temperature, 8.23 for the pH, and 3.25 h for the reaction time by the central composite design. Under these optimum conditions, L‐sorbose was converted into 2‐KLG with an average yield of 43.70 %.
New Quinoline Derivatives and their Antimicrobial Potential Against Candida Albicans and Staphylococcus Aureus
Authors: Glanzmann Nícolas , de Oliveira Lemos Ari Sérgio , Meinel Raíssa Soares , Torres Branca Matheus , Mayrink Natasha Silva , Da Costa Nunes Isabelle K. , Pereira Henrique Marcelo Gualberto , Coimbra Elaine Soares , Fabri Rodrigo Luiz , da Silva Adilson David 
Published: September 2024

AbstractAntimicrobial resistance is a pressing global health concern, demanding the development of novel antimicrobial agents. Quinoline derivatives emerge as promising candidates with their diverse chemical structures and recognized bioactive properties. This study aimed to investigate the antimicrobial potency of newly synthesized quinoline derivatives against Candida albicans and five bacterial strains, which are responsible for various infections and have exhibited varying degrees of antibiotic resistance. A series of quinoline derivatives were synthesized through simple structural modifications, such as the inclusion of nitro, amino, and hydrazino groups, or using the molecular hybridization strategy, involving the combination of quinoline and 1,2,3‐triazoles. None of the compounds showed promising activity against the bacterial strains. However, a promising fungistatic effect was observed against C. albicans. In this test, two of the compounds showed lower MIC values than fluconazole (25 μg/mL). In addition, the most promising compounds showed high affinity for the enzyme lanosterol 14 alpha demethylase, due to the low energy values found (−7.6 and −8.2 kcal/mol). Our study offers new avenues for future drug development in the fight against antimicrobial resistance.
Exploring Nano‐Protein Corona Dynamics: Tracing the Hard‐to‐Soft Corona Transition with Trypsin and Graphene Oxide in a Silver Nanocomposite Model
Authors: Sharma Navita , Yadav Deepika , Kumari Sujata , Ghosh Debasree , Shandilya Manish , Hassan Md. Imtaiyaz , Srivastava Chandra Mohan , Majumder Sudip 
Published: September 2024

AbstractIn this work, the adsorption of Trypsin on synthesized Silver (Ag), Graphene Oxide: Silver (GO: Ag) nanocomposite (2:1), and Graphene Oxide (GO) nanoparticles (NPs) and, their effect on the conformation of Trypsin was studied by various spectroscopic and microscopic techniques to understand the transition of nano Protein Corona (PC) from “hard” to “soft.” The results showed that the adsorption of Trypsin on synthesized NPs followed the Freundlich adsorption isotherm and pseudo‐second‐order kinetics. The conformational changes that occurred in Trypsin upon interaction with synthesized NPs were investigated by using Circular Dichroism (CD), Fluorescence, and Fourier Transform Infrared (FTIR) spectroscopy. The morphological investigation of nano PC using High‐Resolution Transmission Electron Microscopy (HR‐TEM) and Atomic Force Microscopy (AFM) indicated the formation of hard, semi‐soft, and soft nano PC in the presence of Ag, GO: Ag, and GO NPs, respectively. The negative value of the thermodynamic parameters ΔG, ΔH, and ΔS in all three cases suggests the reaction to be exothermic and spontaneous. The van der Waals interaction and hydrogen bonding are the major forces responsible for binding Trypsin on the surface of Ag, GO: Ag, and GO. The catalytic efficiency of trypsin in the absence and presence of NPs was examined by performing the protein assay showing the highest catalytic activity of pure Trypsin compared with trypsin‐NPs constructs. Our findings provide useful information for the applications of GO‐based nanocomposites for various biological applications.
How to Experimentally Determine the Influence of the Weak Nuclear Force in Promoting Molecular Chirality via Heavy–Metal Promoted Autocatalytic Synthesis of Amino Acids
Authors: Cowan J. A. 
Published: September 2024

AbstractThe potential impact of the parity non‐conserving (PNC) weak nuclear interaction on the chirality of a nascent chiral carbon center has previously been examined in the context of evolutionary models for enantiomeric selectivity in the formation of natural amino acids and nucleic acids. Since the PNC effect is the only inherently handed property in nature, it is an obvious candidate to consider in those cases where there is a natural selectivity for a specific enantiomer, including the molecular building blocks of the molecules of life. Over geological timeframes, the potential impact of the PNC weak nuclear force on chiral preference appears feasible. Key requirements included an autocatalytic reaction cycle and involvement of metal‐ion catalysts. While prior studies offer no feasible path to experimentally test the hypothesis; the Z5‐dependence of the PNC interaction does suggest that catalysis by heavy elements could yield observable chiral preferences within an experimentally accessible timeframe. Calculations of the magnitude of the effect are presented for select heavy‐elements and it is shown that chiral preference could be observed within a time span of weeks to months when such metals are used to promote amino acid synthesis via an autocatalytic Strecker reaction.
Strategies Employing Transition‐Metal Free Conditions for C−C Bond Formation in Indoles
Authors: Ghodake Balaji M. , Paul Sayantan , Bhattacharya Asish K. 
Published: September 2024

AbstractIndole motifs are omnipresent in nature and can be found in many natural products as well as pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic of interest for the organic and medicinal chemist community for decades. In this review, we have emphasized the functionalization of indoles via transition‐metal‐free approaches. This review touches on many aspects in different sub‐sections, which gives a proposition of the tactics employed for the functionalization of indoles and an overview of the road ahead.
Metal Complexes of Cobalt Chloride with Vinyl‐, Allyl‐ and Styrylbenzimidazole Ligands: Synthesis, Structure, and Properties
Authors: Sterkhova Irina V. , Parshina Lidiya N. , Grishchenko Lyudmila A. , Borodina Tat'yana N. , Belovezhets Lyudmila A. , Semenov Valentin A. 
Published: September 2024

AbstractThree N‐substituted benzimidazole cobalt(II) complexes have been synthesized and fully characterized by elemental analysis, FT‐IR spectroscopy, and X‐ray crystallography. The crystal packing formation features were studied by AIM analysis, and the energy and nature of both weak noncovalent interactions in the crystal and metal–ligand coordination bonds were assessed. These N‐coordinated cobalt(II) complexes were screened for antimicrobial activities against Gram‐negative (Escherichia coli, Bacillus subtilis) and Gram‐positive (Enterococcus durans) bacteria. Minimal inhibitory concentrations (MIC = 6.2 mg/mL) were found for complex cobalt chloride with allylbenzimidazole ligands against E. durans and E. coli. Its antimicrobial activity is several times higher compared to the reference gentamicin. Molecular docking made it possible to consider the nature of binding of cobalt metal complexes with vinyl‐, allyl‐ and styrylbenzimidazole ligands to biological targets and estimate their energy. The binding energy meanings depend on protein and ligand type, and reaches 8 kcal/mol.
Access to Seleno‐Functionalized Thiazolo[3,2‐a]Pyrimidinones and Pyrimido[2,1‐b][1,3]Thiazinones via Selenocyclization of 2‐Alkenylthiopyrimidinones and Their Fused Analogs
Authors: Vaskevych Alla , Shishkina Svitlana , Dekhtyar Maryna , Smolii Oleg , Vovk Mykhailo 
Published: September 2024

AbstractThe methodology of electrophilic selenylation/cyclization of 2‐alkenylthiopyrimidinones and their fused analogs underlies most of the reported synthetic approaches to seleno‐functionalized thiazolo[3,2‐a]pyrimidinones and pyrimido[2,1‐b][1,3]thiazinones. We have developed a novel implementation of this strategy using as reagent phenylselenyl chloride or the visible‐light‐induced radical‐generating (PhSe)2/CBr4 system. The effect of the unsaturated substrate structure and reaction conditions on the selenocyclization regioselectivity has been revealed and analyzed in detail. It has been established that regardless of the conditions used, 2‐allylthiopyrimidinones react with selenylating agents via electrophilic 5‐exo‐trig cyclization mainly involving the N1 nitrogen atom to give selenium‐containing thiazolo[3,2‐a]pyrimidinones as major products. On the contrary, the selenocyclization with 2‐cinnamylthiopyrimidinones is dominated by the 6‐endo‐trig mode: it mostly involves six‐membered ring closure at the N1 or N3 atom thus leading to selenylated pyrimido[2,1‐b][1,3]thiazinones, with the regiochemistry governed by the position and nature of the substituents on the substrate pyrimidine ring. However, some of the fused cinnamylthio‐substituted substrates yield 5‐exo‐trig cyclized products in the LiClO4/МеNO2 system (a sufficiently polar solvent with a strong electrolyte added).
Posttraumatic growth among Israeli female combat veterans: The mediating roles of posttraumatic stress symptoms and self‐efficacy
Authors: Zerach Gadi 
Published: September 2024

AbstractPosttraumatic growth (PTG) is a possible common reaction to exposure to potentially traumatic events (PTEs) during military service. However, knowledge about correlates of PTG among female combat veterans is sparse. This study examines associations between combat exposure, posttraumatic stress symptoms (PTSS), general self‐efficacy (GSE), and PTG among Israeli female veterans. This is a cross‐sectional studyA volunteer sample of female Israeli combat veterans (n = 616) and non‐combat veterans (n = 484) responded to self‐report questionnaires. Combat veterans reported higher levels of combat exposure, PTSS, GSE, and PTG, as compared to non‐combat veterans. Among combat veterans, combat exposure and GSE were associated with greater PTG. Importantly, PTSS and GSE mediated the link between combat exposure and PTG. The study's findings are among the first to report about possible psychological growth outcomes among Israeli combat veterans. Clinicians treating female veterans coping with combat trauma should be aware of the heterogeneity of reactions to military service challenges and the importance of enhancing veterans' GSE to facilitate PTG.
Complex system management: Intuition and/or analysis with artificial intelligence involvement
Authors: Hallo Leonie , Nguyen Tiep , Chileshe Nicholas , Nguyen Ba Quang Vinh 
Published: September 2024

AbstractThis paper tackles the largely untouched issue of optimal management of complex systems, now rendered much more challenging by current conditions of instability and turbulence. Managers need capabilities of foresight and holism in capturing the essence of wicked problems and the best way forward. Interviews were conducted with complex systems managers regarding their perceptions of the value of analysis and intuition in these circumstances and the potential of artificial intelligence (AI) to bring extra value to both modes, analysis, and intuition. Findings indicate that both styles were employed, and descriptions of intuition covered both experience‐based intuition and creative intuition. Regarding the encroachment of AI, the advantages of speed and reduced costs seemed to these respondents to make its adoption mandatory. However, the oversight role of people was considered critical by most respondents. The paper presents a framework to assist managers in understanding the relative roles of AI, analysis, and intuition as these relate to the complexity level of the system being managed.
Mathematical modeling of convective heat transfer enhancement using circular cylinders in an inverted T‐shaped porous enclosure
Authors: Kumar Sumant , Krishna Murthy S. V. S. S. N. V. G. , Kumar B. V. Rathish , Parmar Deepika 
Published: September 2024

AbstractThe present research aims to improve the convective thermal transport rate of a hybrid nanofluid within an inverted T‐shaped porous enclosure using strategically placed cold circular cylinders. Different locations of circular cylinders in the physical domain are distinguished with nomenclatures as Cases C0‐C4. The mathematical model, based on the Darcy–Brinkman–Forchheimer equation, is numerically simulated through the penalty finite element method. Fluid flow and heat transfer characteristics are depicted graphically, showcasing streamlines, isotherms, mean Nusselt number (), and heat transfer enhancement percentage (En%) across varied thermo‐physical parameters, including Rayleigh number (), Darcy number (), and porosity values (). Notably, the presence of two circular cylinders at the bottom flow zones (Case C4) demonstrates superior heat transfer compared to other spatial cylinder arrangements with increasing . Furthermore, augmenting flow parameters () in the case C4 model intensifies convective heat and fluid flow phenomena. A comparative analysis of thermal transport activity between Case C4 and the simple physical domain (Case C0) reveals maximum thermal enhancement of 166%, 167%, and 36% across varying , , and values. This comprehensive analysis suggests that two circular cylinders (Case C4) at the bottom flow section of the porous enclosure provide an effective strategy for enhancing convective fluid and thermal transport phenomena in an inverted T‐shaped porous enclosure. Moreover, this research significantly contributes in optimizing the thermal transport engineering of T‐shaped applications like solar collectors, exchangers, and heat storage.
A Humanistic Approach to Recommender Systems: Implications for 5.0 Marketing Management
Authors: Lile Ramona , Cuc Lavinia Denisia , Pantea Mioara Florina , Rad Dana 
Published: September 2024

AbstractIn the producer-customer interaction, humanistic management places a strong emphasis on the end-user interests. This perspective embraces a number of more focused philosophies that highly value human development, potential, and dignity. A reaction to the emerging mega-trend that calls for reevaluating marketing is humanistic marketing. Recently, 5.0 marketing management was created by integrating conventional theories of consumer behavior with fundamental concepts from humanistic psychology, such as the ability for self-actualization, self-direction, and choice. Currently, research on online consumer behavior examines how customers select products from e-commerce platforms, and recommendation engines are crucial to this process. A sort of information filtering system called a recommender system makes suggestions for products or services based on the user’s areas of greatest interest. The present cross-sectional research will further investigate how the main types of recommender systems—social-aware recommender systems, robust recommender systems, and explainable recommender systems—are perceived by individuals depending on three psychological characteristics: trust, suspiciousness, and fast and slow thinking decision-making system. A sequential mediation analysis was employed, and a significant indirect effect was observed, results indicating the impact of anchoring effect. Implications are discussed with regard to an efficient 5.0 marketing management strategy.
The Culture of Quality and the Organizational Behavior of Knowledge Organizations in the COVID Context
Authors: Țîțu Aurel Mihail , Oprean Constantin , Pop Alina Bianca , Țîțu Ștefan , Ceocea Costel , Dragomir Camelia Cristina 
Published: September 2024

AbstractThe SARS-CoV-2 pandemic, which is currently present in every country, has had a significant and unique effect on organizations all over the world. The abrupt move to remote work and virtual communication, among other things, has upset the old concepts of organizational behavior, organizational culture, quality culture, and management with all that encompasses it. This study intends to examine how the SARS-CoV-2 pandemic affects several aspects of organizational life and, implicitly, people’s decision-making, with a special emphasis on the meritocracy system in the company. These broad changes, to which the study’s authors refer, also resulted in a shift in organizational culture that put more of an emphasis on adaptability and flexibility. The overall message of the study is that the SARS-CoV-2 pandemic has brought attention to the value of meritocracy in the workplace since it may help identify and advance high-performing workers even in the face of challenges. This study emphasizes the nature and function of universities in contemporary society as knowledge-based institutions, as well as the effects of the SARS-CoV-2 pandemic on universities as a whole and on those who work there as professors and more esteemed mentors. The researchers encourage and make recommendations for specific qualitative indicators that might be used in a setting resembling a university to enhance communication management with all conceivable connections to university administration. The evidence we provide shows that universities play a crucial role in society by facilitating access to knowledge, encouraging critical but also constructive thinking, and aiding in the intellectual growth of individuals. Universities and other organizations are facing tough problems because of the pandemic, including the need to transition to “distance” learning and keep up with emerging digital technology. To ensure the continuation of learning and to support both students and professors, it is stressed the significance of excellent communication management in universities and the need for clear and effective communication techniques. Managing a university-type organization can require effective and efficient communication to be successful. In this well-documented study, several qualitative indicators are put forth that can be used to enhance communication management in a setting resembling a university, to balance the quality culture, and to implement the proper paradigm for meritocracy. These signs include increasing transparency, open and effective employee participation, and the emergence of an open and honest communication culture. In a different vein, the study suggests a new paradigm, namely, the open presentation and operationalization of certain potential benefits that may arise from the successful use of these indicators, as well as the approaches to evaluating their efficacy and efficiency.
Modern Instrument for Nonconformities’ Management Within Quality Management Systems
Authors: Popa Maria , Glevitzky Ioana , Glevitzky Mirel , Popa Dorin Victor , Popa Doriana Maria , Titu Aurel Mihail , Oprean Constantin , Achim Moise Ioan 
Published: September 2024

AbstractNonconformities represent a frequently encountered factor in the operation of a company. It is imperative to constantly investigate the causes and sources of irregularities. For this purpose, for nonsatisfaction of the specified requirements, Kaizen management methods and tools can be used, which offer solutions to improve the nonconformity management process. In industry, regardless of the activity field, software applications that deal with and manage nonconformities can be created, depending on the potential or actual severity of the problem. The paper presents a modern tool, designed to manage nonconformities within a company. Entitled Auto-Quality Matrix, the application was developed and tested in a food industry unit whose field of activity is spring water bottling. The application can be constituted in a standardized process, which can work both on material and information flow, contributing to the visualization of the “quality level” of each individual section and its evolution. On the other hand, it helps to identify nonconformities as close as possible to the area that generates them. The results of the study highlight the advantages of using the new tool, while also exposing the conceptual approach that substantiates its design and validation.
Introduction
Authors: Płotka Witold 
Published: September 2024

AbstractLeopold Blaustein (1905–1942 [or 1944]) was a Polish-Jewish philosopher, aesthetician, psychologist, schoolteacher, and educationalist whose thought was shaped on the border between the main intellectual trends in Poland and Europe in the nineteenth and twentieth centuries. Like a lens, his eclectic but original philosophy focused on new readings in the legacy of descriptive psychology, phenomenology, and Gestalt psychology. Certainly, he was well trained in these divergent yet intertwined traditions. After all, Blaustein was educated in Lvov (Lwów, now Lviv in Ukraine), where his teachers were, among others, Kazimierz Twardowski—a disciple of Franz Brentano in Vienna—who supervised his doctoral dissertation, and Roman Ingarden, who was working at that time on the basics of his phenomenological aesthetics, presented later in 1931 in Das literarische Kunstwerk [The Literary Work of Art]. Importantly, while working on his thesis in 1925, Blaustein studied for a few weeks in Freiburg im Breisgau under Edmund Husserl, who was lecturing then on phenomenological psychology. In addition, in 1927/28, he spent a few months in Berlin, where he had occasion to attend lectures given by Carl Stumpf or Max Wertheimer, not to mention his visits to the Berlin Psychological Institute. After his return to Poland in 1928, Blaustein published his first monograph in Polish, Husserlowska nauka o akcie, treści i przedmiocie przedstawienia [Husserl’s Theory of Act, Content and Object of Presentation], which was devoted solely to Husserl’s philosophy. This book is arguably the very first scholarly work which reads Husserl’s idea of intentionality in the context of Brentano and Bernard Bolzano. Later, Blaustein worked out an original methodological device which allowed him to study phenomena such as experiencing a theater play, a movie, or a radio drama. He also explored new ideas in humanistic psychology and the latest attempts to implement phenomenological tools in psychiatry. With this in mind, it should come as no surprise which scholars often emphasize the novelty of Blaustein’s approach.