bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life Outcomes for Cabozantinib Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma: METEOR Phase III Randomized Trial
Authors: Cella David , Escudier Bernard , Tannir Nizar M. , Powles Thomas , Donskov Frede , Peltola Katriina , Schmidinger Manuela , Heng Daniel Y.C. , Mainwaring Paul N. , Hammers Hans J. , Lee Jae Lyun , Roth Bruce J. , Marteau Florence , Williams Paul , Baer John , Mangeshkar Milan , Scheffold Christian , Hutson Thomas E. , Pal Sumanta , Motzer Robert J. , Choueiri Toni K. 
Published: January 2018

Purpose In the phase III METEOR trial ( ClinicalTrials.gov identifier: NCT01865747), 658 previously treated patients with advanced renal cell carcinoma were randomly assigned 1:1 to receive cabozantinib or everolimus. The cabozantinib arm had improved progression-free survival, overall survival, and objective response rate compared with everolimus. Changes in quality of life (QoL), an exploratory end point, are reported here. Patients and Methods Patients completed the 19-item Functional Assessment of Cancer Therapy–Kidney Symptom Index (FKSI-19) and the five-level EuroQol (EQ-5D-5L) questionnaires at baseline and throughout the study. The nine-item FKSI–Disease-Related Symptoms (FKSI-DRS), a subset of FKSI-19, was also investigated. Data were summarized descriptively and by repeated-measures analysis (for which a clinically relevant difference was an effect size ≥ 0.3). Time to deterioration (TTD) was defined as the earlier of date of death, radiographic progressive disease, or ≥ 4-point decrease from baseline in FKSI-DRS. Results The QoL questionnaire completion rates remained ≥ 75% through week 48 in each arm. There was no difference over time for FKSI-19 Total, FKSI-DRS, or EQ-5D data between the cabozantinib and everolimus arms. Among the individual FKSI-19 items, cabozantinib was associated with worse diarrhea and nausea; everolimus was associated with worse shortness of breath. These differences are consistent with the adverse event profile of each drug. Cabozantinib improved TTD overall, with a marked improvement in patients with bone metastases at baseline. Conclusion In patients with advanced renal cell carcinoma, relative to everolimus, cabozantinib generally maintained QoL to a similar extent. Compared with everolimus, cabozantinib extended TTD overall and markedly improved TTD in patients with bone metastases.
Evaluation of spinal involvement in children with mucopolysaccharidosis VI: the role of MRI
Authors: Bulut Elif , Pektas Emine , Sivri Hatice S , Bilginer Burcak , Umaroglu Mumtaz M , Ozgen Burce 
Published: January 2018

Objective:
To evaluate spinal MRI features of mucopolysaccharidosis (MPS) VI and to assess the correlation with clinical findings.

Methods:
We retrospectively evaluated spinal MRI scans and clinical findings at the time of imaging in 14 patients (8 male, 6 female) with MPS VI. Craniometric measurements were performed and the images were assessed for bony anomalies, spinal stenosis and spinal cord compression. The degree of cervical cord compression was scored and correlated with neurological examination findings at the time of imaging. Vertebral alignment, structural changes in spinal ligaments and intervertebral discs were also assessed.

Results:
All patients had cervical stenosis due to bony stenosis and thickened retrodental tissue (median: 6.05 mm, range 3.3–8 mm). Retrodental tissue thickness was found to increase with age (p = 0.042). Compressive myelopathy was detected at upper cervical level in 11 (79%) and lower thoracic level in 2 patients (14%). Significant inverse correlation was found between cervical myelopathy scores and neurological strength scores. The most common bony changes were hypo/dysplastic odontoid; cervical platyspondyly with anterior inferior beaking; thoracic posterior end plate depressions and lumbar posterior scalloping. Kyphosis due to retrolisthesis of the beaked lumbar vertebrae and acute sacrococcygeal angulations were other remarkable findings.

Conclusion:
MRI is an essential component in evaluation of spinal involvement in MPS VI, and scanning of the entire spine is recommended to rule out thoracic cord compression.

Advances in knowledge:
This study provides a detailed description of spinal MRI findings in MPS VI and underlines the role of MRI in management of cord compression.
Competitive vs. Complementary Effects in Online Social Networks and News Consumption: A Natural Experiment
Authors: Sismeiro Catarina , Mahmood Ammara 
Published: January 2018

Using hourly traffic and readership data from a major news website, and taking advantage of a global Facebook outage, we study the relationship between social networks and online news consumption. More specifically, we test if online social networks compete with content providers or instead play a complementary role by promoting and attracting traffic to external websites. During the outage, consistent with a promotional effect, we observe a significant decrease in traffic and unique visitors to the news website lasting beyond the outage hours. We further find that direct referrals from Facebook links grossly underestimated the actual impact of Facebook in generating traffic. Instead, during the outage, we observe a more significant reduction in visitors arriving at the news website from search engines or directly typing the website URL or using bookmarks. Additionally, readership of articles and types of pages viewed also changed during the outage. Although we observe a drop in news consumption during the outage hours for all news categories, the subsequent news consumption differs across categories. Time sensitive categories like sports and local news see an increase in consumption, whereas news on women issues or health topics see a decrease. Analysis of individual-level visit and readership behavior during the outage also reveals that Facebook not only introduces selectivity bias by attracting shallower readers but also changes readership patterns (in the absence of Facebook, visitors engage in more in-depth reading). To test the generalizability of our results, we study the impact of the outage on referrals from other social media outlets, on other news sites, and on other content and e-commerce sites. We find similar effects on other news providers, whereas data from nonnews sites, including e-commerce, show no major outage effects. Overall, our results have important managerial implications. We highlight how our results unearth the importance of search engine optimization and of strong branding for news websites, if providers want to harness fully the power of their social media presence.This paper was accepted by Chris Forman, information systems.
Patient safety in dentistry
Authors: Renton Tara , Master Selina , Pemberton Mike 
Published: January 2018

Patient safety is the absence of preventable harm to a patient during the process of healthcare and is critical to the provision of a quality service. Many National Health Service (NHS) improvement initiatives have been developed in relation to patient safety, resulting in changes in culture, reporting and learning. These include the publication by the NHS England Surgical Never Events taskforce of ‘Standardize, educate, harmonize, commissioning the conditions for safer surgery’ in 2014 which was followed in 2015 by ‘National Safety Standards for Invasive Procedures (NatSSIPs)’. The principles identified in NatSSIPs are now being rolled out to local areas for their interpretation (Local Safety Standards for Invasive Procedures [LocSSIPs]). CPD/Clinical Relevance: The aim of this article is to inform and update the reader on recent NHS England patient safety initiatives as applicable to dentistry, specifically the development of an example LocSSIP for wrong site extraction.
Migration of bone graft material into the maxillary sinus: a case report
Authors: Evangelou Christina , Peck Georgina , Somaia Nishma , Halfpenny Wayne 
Published: January 2018

A 48-year-old patient presented at the Oral and Maxillofacial Surgery department complaining of symptoms of chronic sinusitis and gave a history of a recent sinus lift procedure in primary care. The patient was examined and investigated via a CBCT which showed extruded bone graft material in the left maxillary antrum. The patient then had to undergo surgery under general anaesthetic to remove the foreign material from the antrum, which eventually relieved his symptoms. This paper discusses potential complications of sinus lift procedures, including perforation of the Schneiderian membrane, perioperative recognition, potential management and how to avoid this complication.CPD/Clinical Relevance: Membrane perforation is the most common complication of sinus lift procedures. Clinicians need to be aware of the risk, presenting symptoms, investigation and necessary treatment of this complication.
HUBUNGAN TINGKAT PENGETAHUAN IBU NIFAS TENTANG PERAWATAN LUKA PERINEUM DAN STATUS GIZI DENGAN PROSES PENYEMBUHAN LUKA
Authors: Hanum Diyana 
Published: January 2018

Latar Belakang : Tindakan episiotomi seringkali harus dilakukan untuk mencegah terjadinya ruptur perineum. Ibu nifas dengan luka perineum harus mempunyai pengetahuan yang cukup tentang cara merawat luka perineum dan faktor-faktor yang mempengaruhi penyembuhan luka. Selain itu status gizi ibu nifas harus diperhatikan sejak masa kehamilan. Karena zat gizi sangat dibutuhkan untuk memulihkan kesehatan ibu setelah melahirkan, untuk memenuhi produksi air susu dan penyembuhan luka perineum. Bila ibu nifas mampu melakukan perawatan luka perineum dengan benar selama di rumah ditunjang dengan status gizi yang cukup, maka resiko terjadinya infeksi masa nifas bisa dihindari. Tujuan penelitian : Untuk mengetahui hubungan tingkat pengetahuan ibu nifas tentang perawatan luka perineum dan status gizi dengan proses penyembuhan luka di Poli KIA RS. Pantiwilasa Citarum. Metodologi penelitian : Penelitian ini merupakan penelitian kuantitatif korelasi dengan pendekatan cross sectional. Populasi penelitian adalah ibu-ibu nifas dengan luka perineum di poli KIA RS Panti Wilasa Semarang. Pengambilan sampel menggunakan total sampling dengan jumlah sampel sebanyak 40 orang. Hasil penelitian : Uji korelasi menggunakan Chi Square diperoleh hasil sinifikan dengan (P value 0.030) dan (P value 0.008) Kesimpulan : Ada hubungan tingkat pengetahuan ibu nifas tentang perawatan luka perineum dengan proses penyembuhan luka. Juga ada hubungan status gizi dengan proses penyembuhan luka di poli KIA rumah sakit Panti Wilasa Semarang. Kata kunci : Pengetahuan ,status gizi,proses penyembuhan luka
PENGEMBANGAN SITUS E-LEARNING DENGAN MOODLE VERSI 3.1 SEBAGAI MEDIA PEMBELAJARAN PADA PROGRAM STUDI PENDIDIKAN GURU MADRASAH IBTIDAIYAH
Authors: Batubara Hamdan Husein 
Published: January 2018

This study aims to create an e-learning site with Moodle version 3.1. and review the results of its use as learning media in the department of elementary schoolteacher education. This research uses research and development design to produce an e-learning website. The registration method on the e-learning site is email-based self-registration. Users who successfully register on the e-learning site will get the authentical user role. Authentical users can register on a course by using a course password. The administrator assigns the Manager role for the lecturer’s account so that they can create and enroll himself as a teacher on a course page. Every teacher has obligation to present matter with single page, or file, or folder, or URL. Teacher can add learning activities using forums, online assignments, online exams, feedbacks, and online questionnaires. The average score of media experts states that the quality of e-learning is in good category and e-learning users welcome the use of e-learning as a medium of learning and assessment. The products developed have met the advice of media experts and e-learning users.
Gdy królewską godność zachowały tylko kamienne lwy…, czyli o językowej kreacji lwa w piosenkach Jacka Kaczmarskiego
Authors: Kępka Izabela 
Published: January 2018

The main goal of the article is showing the language creation of a lion in songs by Jacek Kaczmarski. The theme of the lion, helps to show the situation of the people enslaved in a communist country. The lion, the symbol of power and bravery, in Kaczmarski’s poetry is mainly shown as an attraction in circus. It is weak, disoriented and frightened. This stereotypical proud animal, became a weak creature, which is laughed at by the spectators.Only fake lions made out of stone along with the Zodiac Leo and people named Lion, didn’t lose their proudness and bravery. Those can remind us about the characteristics of a true lion, but are also guardian of true, wise and honest authority. Kaczmarski’s lions symbolize an enslaved, weak nation that, on the other hand, have the awareness of their power and wait for the fall of the regime.
Lingwistyczna charakterystyka kontraktu jako gatunku na przykładzie mowy propinacyjnej z XIX wieku
Authors: Kuć Joanna 
Published: January 2018

The article is an attempt of a genre analysis of the nineteenth-century sale alcohol agreement as a contract. This is a special document, because this type of act was written only once (L-140) on 412 analyzed contracts. The genre scheme of the old contract is possible to compare it with other nineteenth-century contracts. Although not easy to describe because of the typological confusion and not always the unambiguous genre signals (contract / intermediary declaration / sale alcohol agreement), they are similar to modern notarial contracts of this type. The basic registers of quality features of a nineteenth-century contract are: a clear functional intention, a coherent, formalized structure, a monolithic, specific dialogue between the sender and the receiver, the sender’s autocreation as an expert in legal action serves to build the impression of a contract involving two parties. At the source of the contract lies one of the basic speech acts: a declaration that evokes agreement, used in many social and communication situations.
Piśmiennictwo religijne Tatarów Wielkiego Księstwa Litewskiego jako oryginalne źródło do badań polszczyzny północnokresowej
Authors: Kulwicka-Kamińska Joanna 
Published: January 2018

The religious writings of the Tatars constitute a valuable source for philological research due to the presence of heretofore unexplored grammatical and lexical layers of the north borderland Polish language of the 16th-20th centuries and due to the interference-related and transfer-related processes in the context of Slavic languages and Slavic-Oriental contacts. Therefore the basis for linguistic analyses is constituted by one of the most valuable monuments of this body of writing – the first translation of the Quran into a Slavic language in the world (probably representing the north borderland Polish language), which assumed the form of a tefsir. The source of linguistic analyses is constituted by the Olita tefsir, which dates back to 1723 (supplemented and corrected in the 19th century). On the basis of the material that was excerpted from this work the author presents both borderland features described in the subject literature and tries to point the new or only sparsely confirmed facts in the history of the Polish language, including the formation of the north borderland Polish language on the Belarusian substrate. Research involves all levels of language – the phonetic-phonological, morphological, syntactic and the lexical-semantic levels.
De-Contextualisation or Re-Contextualisation: Tibetan Buddhism in the Náprstek Museum
Authors: Heroldová Helena 
Published: January 2018

AbstractThe study based on the preparation ofPříběh Tibetu[The Story of Tibet] exhibition in the Náprstek Museum focuses on the de-contextualisation of Tibetan Buddhism objects in the museum setting. It deals with the stages of the decontextualisation process from the removing of the original material environment and social context to creation of new meanings in the museum. Namely it discusses aestheticisation and its relation to the art-gallery style exhibition.
Likeℕ’s – a point of view on natural numbers
Authors: Tutaj Edward 
Published: January 2018

Abstract
We define and study some simple structures which we call likens and which are conceptually near to both sets of natural numbers, i.e. ℕ with addition and ℕ* = ℕ \ {0} with multiplication. It appears that there are many different likens, which makes it possible to look on usual natural numbers from a more general point of view. In particular, we show that ℕ and ℕ* are related to some functionals on the space of likens. A similar idea is known for a long time as the Beurling generalized numbers. Our approach may be considered as a little more natural and more general, since it admits the finitely generated likens.
Elementary steps in heterogeneous catalysis: The basis for environmental chemistry
Authors: Ertl Gerhard , Zielińska Maria , Rajfur Małgorzata , Wacławek Maria 
Published: January 2018

Abstract
Catalysis is an alternative way for reaching an immediate formation of a product, because of a lower energy barrier (between the molecules and the catalysts). Heterogeneous catalysis comprises the acceleration of a chemical reaction through interaction of the molecules involved with the surface of a solid. It is a discipline, which involves all the different aspects of chemistry: inorganic and analytical chemistry in order to characterize the catalysts and the forms of these catalysts. The industrial chemistry puts all these things together to understand the solid chemical handling, chemical reaction and energy engineering and the heat and mass transfer in these catalytic processes. Very often there are more than one, but several products, then the role of the catalyst is not so much related to activity, but to selectivity. The underlying elementary steps can now be investigated down to the atomic scale as will be illustrated mainly with two examples: the oxidation of carbon monoxide (car exhaust catalyst) and the synthesis of ammonia (the basis for nitrogen fertilizer). There is a huge market for the catalysts themselves despite of their high costs. A large fraction is used for petroleum refineries, automotive and industrial cleaning processes. The catalytic processes is a wide field and there are still many problems concerning energy conservation and energy transformation, so there is much to do in the future.
How can pupils see what is invisible?: Possibilities of inquiry probeware experiment implementation in primary schools
Authors: Gašparík Vladimír , Prokša Miroslav , Drozdíková Anna 
Published: January 2018

Abstract
We investigated the difficulties and challenges for teachers in implementing microcomputer-based laboratory and inquiry-based education in basic schools, where pupils were unused to this type of education. To achieve this, we implemented lesson models with worksheets focused on chemical reactions, chemical decomposition and chemical synthesis; with demonstration experiments and video-recording of each lesson. We then utilized a qualitative research design to analyse the videos, concentrating on circumstances leading to increased and decreased pupil attention to the relevant events, and on subsequent student reflection. Experience gained from implementing our model lessons proved that achieving effective teacher-pupil communication was the greatest difficulty hindering teaching success. This particularly involved the formulation of predictions and conclusions which demands strong commitment, determination and skill from every teacher. A further difficulty was ensuring active pupil engagement in the discussion. We therefore instituted a set of teacher ‘working-rules’ to enhance success in this innovative form of education.
Attitudes among chemistry teachers towards increasing personal competencies in applying ICT
Authors: Karolčík Štefan , Čipková Elena 
Published: January 2018

Abstract
The study analyses opinions and attitudes among Chemistry teachers participating in the national project titled “Modernisation of the Educational Process in Primary and Secondary Schools”. The research part of the study consists of the results of our findings examining the overall satisfaction of course participants with the professional level, difficulty, and contents of the designed TPACK-based (the Technological Pedagogical Content Knowledge) teaching model, as well as their self-assessment of the acquired skills and knowledge regarding the work with particular software and hardware applications. The results indicate that the course based on the TPACK framework and comprising specific examples of teaching activities supported by the use of technology was highly appreciated by teachers. Examples of methodologies for a suitable use of digital technologies in a particular curriculum topic in Chemistry, based on the TPACK model, were evaluated by teachers as the most beneficial ones, in terms of the actual teaching practice. The research confirmed that teachers expect to receive educational technologies together with high-quality methodical guidelines and particular examples of teaching activities involving appropriate and efficient use of the given digital technology in the teaching process.
Diplodiscus mehrai Pande, 1937 and D. japonicus (Yamaguti, 1936): morphology of developmental stages and molecular data
Authors: Besprozvannykh V. V. , Rozhkovan K. V. , Ermolenko A. V. , Izrailskaya A. V. 
Published: January 2018

Summary
Specimens of the snails Anisus centrifugops were infected with two types of cercariae relating to the genus Diplodiscus, differing from each other by body and organ sizes were found in a pond in the territory of Vladivostok (Primorsky region, Russia). Further study of their morphology and life cycles allowed us to establish that these flukes belong to Diplodiscus japonicus (Yamaguti, 1936) and D. mehrai Pande, 1937. Morphological and molecular data confirmed the validity of D. japonicus which had previously been synonymized with D. amphichrus Tubangui, 1933 and D. mehrai Pande, 1937.