bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYC Overexpression at the Protein and mRNA Level and Cancer Outcomes among Men Treated with Radical Prostatectomy for Prostate Cancer
Authors: Pettersson Andreas , Gerke Travis , Penney Kathryn L. , Lis Rosina T. , Stack Edward C. , Pértega-Gomes Nelma , Zadra Giorgia , Tyekucheva Svitlana , Giovannucci Edward L. , Mucci Lorelei A. , Loda Massimo 
Published: November 2017

Abstract
Background: The proto-oncogene MYC is implicated in prostate cancer progression. Whether MYC tumor expression at the protein or mRNA level is associated with poorer prognosis has not been well studied.
Methods: We conducted a cohort study including 634 men from the Physicians' Health Study and Health Professionals Follow-up Study treated with radical prostatectomy for prostate cancer in 1983–2004 and followed up for a median of 13.7 years. MYC protein expression was evaluated using IHC, and we used Cox regression to calculate HRs and 95% confidence intervals (CIs) of its association with lethal prostate cancer (distant metastases/prostate cancer–related death). We assessed the association between MYC mRNA expression and lethal prostate cancer in a case–control study, including 113 lethal cases and 291 indolent controls.
Results: MYC nuclear protein expression was present in 97% of tumors. MYC protein expression was positively correlated with tumor proliferation rate (r = 0.37; P &lt; 0.001) and negatively correlated with apoptotic count (r = −0.17; P &lt; 0.001). There were no significant associations between MYC protein expression and stage, grade, or PSA level at diagnosis. The multivariable HR for lethal prostate cancer among men in the top versus bottom quartile of MYC protein expression was 1.09 (95% CI, 0.50–2.35). There was no significant association between MYC mRNA expression and lethal prostate cancer.
Conclusions: Neither MYC protein overexpression nor MYC mRNA overexpression are strong prognostic markers in men treated with radical prostatectomy for prostate cancer.
Impact: This is the largest study to examine the prognostic role of MYC protein and mRNA expression in prostate cancer. Cancer Epidemiol Biomarkers Prev; 27(2); 201–7. ©2017 AACR.
Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium
Authors: Harris Holly R. , Babic Ana , Webb Penelope M. , Nagle Christina M. , Jordan Susan J. , Risch Harvey A. , Rossing Mary Anne , Doherty Jennifer A. , Goodman Marc T. , Modugno Francesmary , Ness Roberta B. , Moysich Kirsten B. , Kjær Susanne K. , Høgdall Estrid , Jensen Allan , Schildkraut Joellen M. , Berchuck Andrew , Cramer Daniel W. , Bandera Elisa V. , Wentzensen Nicolas , Kotsopoulos Joanne , Narod Steven A. , Phelan Catherine M. , McLaughlin John R. , Anton-Culver Hoda , Ziogas Argyrios , Pearce Celeste L. , Wu Anna H. , Terry Kathryn L. 
Published: November 2017

Abstract
Background: Polycystic ovary syndrome (PCOS), and one of its distinguishing characteristics, oligomenorrhea, have both been associated with ovarian cancer risk in some but not all studies. However, these associations have been rarely examined by ovarian cancer histotypes, which may explain the lack of clear associations reported in previous studies.
Methods: We analyzed data from 14 case–control studies including 16,594 women with invasive ovarian cancer (n = 13,719) or borderline ovarian disease (n = 2,875) and 17,718 controls. Adjusted study-specific ORs were calculated using logistic regression and combined using random-effects meta-analysis. Pooled histotype-specific ORs were calculated using polytomous logistic regression.
Results: Women reporting menstrual cycle length &gt;35 days had decreased risk of invasive ovarian cancer compared with women reporting cycle length ≤35 days [OR = 0.70; 95% confidence interval (CI) = 0.58–0.84]. Decreased risk of invasive ovarian cancer was also observed among women who reported irregular menstrual cycles compared with women with regular cycles (OR = 0.83; 95% CI = 0.76–0.89). No significant association was observed between self-reported PCOS and invasive ovarian cancer risk (OR = 0.87; 95% CI = 0.65–1.15). There was a decreased risk of all individual invasive histotypes for women with menstrual cycle length &gt;35 days, but no association with serous borderline tumors (Pheterogeneity = 0.006). Similarly, we observed decreased risks of most invasive histotypes among women with irregular cycles, but an increased risk of borderline serous and mucinous tumors (Pheterogeneity &lt; 0.0001).
Conclusions: Our results suggest that menstrual cycle characteristics influence ovarian cancer risk differentially based on histotype.
Impact: These results highlight the importance of examining ovarian cancer risk factors associations by histologic subtype. Cancer Epidemiol Biomarkers Prev; 27(2); 174–82. ©2017 AACR.
The Effects of Resistance Exercise on Biomarkers of Breast Cancer Prognosis: A Pooled Analysis of Three Randomized Trials
Authors: Winters-Stone Kerri M. , Wood Lisa J. , Stoyles Sydnee , Dieckmann Nathan F. 
Published: November 2017

Abstract
Background: Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise (n = 109) to a placebo control condition (n = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression.
Methods: Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months. Linear mixed effects models were used to examine the association between group, biomarkers, and body composition and whether or not changes in muscle strength or body composition influenced the effect of exercise on biomarkers.
Results: CRP decreased over time among women participating in resistance training compared with increases in controls (P = 0.045). In stratified analyses and compared with increases in controls, women who gained strength reduced CRP (P = 0.003) and maintained levels of IL1β and IL6. Among exercisers who lost weight (≥2 kg), CRP (P = 0.045), leptin (P &lt; 0.01), and SAA (P = 0.029) decreased, whereas IGF-BP1 (P = 0.036) increased compared with controls.
Conclusions: Resistance training may lower inflammation and improve insulin pathway profiles, but the magnitude and degree of benefit from exercise may depend upon whether or not women gained strength, a possible marker of compliance with training, and/or lost weight during exercise.
Impact: Future resistance training trials should consider these potential influencing factors as they may determine how well exercise can slow cancer progression and prevent disease recurrence. Cancer Epidemiol Biomarkers Prev; 27(2); 146–53. ©2017 AACR.
From the Judaean Desert to the Great Sea: Qumran in a Mediterranean Context
Authors: Mizzi Dennis 
Published: November 2017

Abstract
The time when Qumran was studied in splendid isolation is long gone, but much work remains to be done when it comes to situating the site in its wider context. In this paper, Qumran is contextualized, on the one hand, within the larger ecological history of the Mediterranean and, on the other, within the Mediterranean world of classical antiquity. Questions regarding the functions of the Qumran settlement are addressed from the perspective of “marginal zones” in the Mediterranean, which provides an ideal backdrop through which to illumine aspects of daily life at Qumran. Furthermore, it is shown how comparative case studies from the Graeco-Roman Mediterranean help us to nuance the discussion concerning “Hellenization” or “Romanization” with regard to Qumran. Finally, a new understanding of L4, which is here interpreted primarily as a dining room, is proposed on the basis of archaeological parallels from the Graeco-Roman world. A pan-Mediterranean perspective, therefore, allows us to generate new insights on old questions and novel interpretations.
Louis Lamm (1871–1943): A Short Biography of a Dedicated Judaica Publisher and Bookseller
Authors: Freudenthal Gad 
Published: November 2017

Abstract
Louis Lamm was a famed bookseller and publisher of Judaica in Berlin and Amsterdam during the four decades preceding his assassination in 1943. Yet even Internet fails to provide elementary biographical details about his life and work. The aim of this short paper is to partially fill this lacuna and contribute to the perpetuation of the memory of a dedicated lover of Jewish books.
Christopher Okigbo’s Poetics and the Politics of Canonization
Authors: Abba Abba A. 
Published: November 2017

Abstract
Christopher Okigbo conveyed in his poetry the sense of patriotism and personal anguish at the monstrosity of a benighted nation. Some critics have argued that Okigbo was not only obsessive in his depictions of metaphors that incarnated the recurring trope of death, but also embodied a death wish culminating in his death in the Nigeria–Biafra war. They further argue that he embodied a suicidal impulse that motivated his general conduct and death in that battle. Unfortunately, only a handful of scholars have sought to contest this view and to illuminate Okigbo’s self-immolation in the name of a higher duty. To be sure, suicide and martyrdom may go beyond the question of dying to the problem of laying one’s death dramatically at someone else’s door. Following Kant’s theory of the ethical act, this paper undertakes a critical intervention that reappraises some of Okigbo’s poetry as well as documented accounts of his life in order to identify him appropriately: is he a genuine martyr or a mere suicide who presides ritually over his own dismemberment, or both? Examining lines of his poetry that have been misread as embodying his ‘haunting’ death-wish, on the one hand, and evidence of his self-giving impulse, on the other, the paper seeks to articulate how Okigbo as a tragic poet transcends his destiny by submitting to it—victor and victim at once. In its conclusion, the paper reconciles Okigbo’s will to heroic action with the symbolic meaning that is locked in his poetry in order to justify his ascension to the rank of martyr.
The Rhetoric of Return in Kunle Afolayan’s Film October 1
Authors: Sesan Azeez Akinwumi 
Published: November 2017

Abstract
The popularity of Nollywood movies has established their relevance in cultural studies to interrogating afresh the presumed norms among people of ethno-cultural and racial difference. To this end, film critics have focused their attention on the theme and genre studies of Nollywood movies with a view to relating the issues in the film texts to the often heated sociological debates on coloniality in African socio-cultural and political experiences. Kunle Afolayan’s October 1 contributes to these raging debates through the motif of return (return to self, return of nation, and return to nation) that runs through the film text. This motif of return contributes to the overall film gestalt through characterization and plot. Postcolonial theory is adopted to describe the return motif through the investigation of consciousness, nostalgia, and trauma, as experienced individually or collectively. The theory explains the nature, pattern, and dimensions of adjustment and adaptation of individuals, communities, and the nation to complexity and dynamism of change during colonial encounters and the journey towards political independence on October 1. The kernel of the movie’s argument is that the country’s independence was heralded by hypocrisy, dishonesty, and violence. The movie thus questions the misconceived notion of racial purity by the white racists through their ignoble role in the return process of the country at the attainment of political independence on 1 October 1960.
The Combined Effect of Cold and Moisture on Manual Performance
Authors: Ray Matthew , Sanli Elizabeth , Brown Robert , Ennis Kerri Ann , Carnahan Heather 
Published: November 2017

Objective The aim of this study was to investigate the combined effect of cold and moisture on manual performance and tactile sensitivity. Background People working in the ocean environment often perform manual work in cold and wet conditions. Although the independent effects of cold and moisture on hand function are known, their combined effect has not been investigated. Method Participants completed sensory (Touch-Test, two-point discrimination) and motor (Purdue Pegboard, Grooved Pegboard, reef knot untying) tests in the following conditions: dry hand, wet hand, cold hand, and cold and wet hand. Results For the Purdue Pegboard and knot untying tasks, the greatest decrement in performance was observed in the cold-and-wet-hand condition, whereas the decrements seen in the cold-hand and wet-hand conditions were similar. In the Grooved Pegboard task, the performance decrements exhibited in the cold-and-wet-hand condition and the cold-hand condition were similar, whereas no decrement was observed in the wet-hand condition. Tactile sensitivity was reduced in the cold conditions for the Touch-Test but not the two-point discrimination test. Conclusion: The combined effect of cold and moisture led to the largest performance decrements except when intrinsic object properties helped with grasp maintenance. The independent effects of cold and moisture on manual performance were comparable. Application Tools and equipment for use in the cold ocean environment should be designed to minimize the effects of cold and moisture on manual performance by including object properties that enhance grasp maintenance and minimize the fine-dexterity requirements.
Preoperative quantitative dynamic contrast-enhanced MRI and diffusion-weighted imaging predict aggressive disease in endometrial cancer
Authors: Fasmer Kristine E , Bjørnerud Atle , Ytre-Hauge Sigmund , Grüner Renate , Tangen Ingvild L , Werner Henrica MJ , Bjørge Line , Salvesen Øyvind O , Trovik Jone , Krakstad Camilla , Haldorsen Ingfrid S 
Published: November 2017

Background Quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) may yield preoperative tumor biomarkers relevant for prognosis and therapy in cancer. Purpose To explore the value of preoperative DCE-MRI and DWI for the prediction of aggressive disease in endometrial cancer patients. Material and Methods Preoperative MRI (1.5-T) from 177 patients were analyzed and imaging parameters reflecting tumor microvasculature (from DCE-MRI) and tumor microstructure (from DWI) were estimated. The derived imaging parameters were explored in relation to clinico-pathological stage, histological subtype and grade, molecular markers, and patient outcome. Results Low tumor blood flow (Fb) and low rate constant for contrast agent intravasation (kep) were associated with high-risk histological subtype ( P ≤ 0.04 for both) and tended to be associated with poor prognosis ( P ≤ 0.09). Low tumor apparent diffusion coefficient (ADC) value and large tumor volume were both significantly associated with deep myometrial invasion ( P < 0.001 for both) and were also unfavorable prognostic factors ( P = 0.05 and P < 0.001, respectively). Conclusion DCE-MRI and DWI represent valuable supplements to conventional MRI by providing preoperative imaging biomarkers that predict aggressive disease in endometrial cancer patients.
Evaluation of a simulation clinic for improving occupational therapy students’ perceptions of interaction with parents and infants
Authors: Springfield Elizabeth , Honnery Michael , Bennett Sally 
Published: November 2017

Introduction Occupational therapy education programmes need to graduate students who can confidently and safely deliver child and youth services. This study explores whether a simulation clinic could increase student perceived knowledge and confidence and decrease student anxiety to better prepare them for professional child and youth practice. Method This study used a pre–post quasi-experimental design. Second-year undergraduate and first-year graduate entry master's level occupational therapy students participated in the simulation clinic as a component of an occupational therapy child and youth course. Students completed pre- and post-simulation questionnaires to measure perceived knowledge, confidence, and anxiety related to infant and parent interactions. Findings A sample of 100 students reported significant improvements for perceived knowledge (all p < 0.001) and confidence (all p < 0.001) across all four skills targeted for development in this simulation: Communication, Information Gathering, Information Sharing, and Clinical Intervention Skills. Students reported a significant decrease in anxiety for parental ( p < 0.001) and infant ( p < 0.001) interaction, and felt the experience to have been highly valuable and realistic. Conclusion Findings indicate that simulation is a valuable tool for preparing occupational therapy students to work with infant and parent interaction. Further research investigating the effect of simulation on student competence is recommended.
Cancer Pain and its Management: A Survey on Interns’ Knowledge, Attitudes and Barriers
Authors: Nimmaanrat Sasikaan , Prechawai Chatchai , Phungrassami Temsak 
Published: November 2017

Objective We conducted this study to evaluate the knowledge and attitudes of interns regarding cancer pain and its management. Materials and methods This study included 116 interns recently graduated from the Faculty of Medicine, Prince of Songkla University. They provided their demographic characteristics and completed a questionnaire in regards to their knowledge and attitudes about cancer pain and its management. Results Data were obtained from 116 interns. The majority of interns did not hesitate to provide maximal doses of analgesics for patients in severe pain when the prognosis was poor. A significant number favored to prescribe pethidine more than morphine and thought that pethidine caused less harmful effects in long-term use. Most respondents agreed or strongly agreed that they would prescribe opioids carefully to avoid tolerance and addiction. They considered that barriers to effective pain management were inadequate knowledge, inadequate pain assessment and lack of time to attend patients’ requirements. Conclusion The interns demonstrated positive attitudes toward cancer pain and its management, principally on opioid usage. However, a significant number of them had misconceptions in terms of knowledge for prescribing opioids. To provide better cancer pain management, attention must be given to improving the curriculum and integrating it into clinical practice.
Reducing sound and light exposure to improve sleep on the adult intensive care unit: An inclusive narrative review
Authors: Bion Victoria , Lowe Alex SW , Puthucheary Zudin , Montgomery Hugh 
Published: November 2017

Purpose Sleep disturbance is common in intensive care units. It is associated with detrimental psychological impacts and has potential to worsen outcome. Irregular exposure to sound and light may disrupt circadian rhythm and cause frequent arousals from sleep. We sought to review the efficacy of environmental interventions to reduce sound and light exposure with the aim of improving patient sleep on adult intensive care units. Methods We searched both PubMed (1966–30 May 2017) and Embase (1974–30 May 2017) for all relevant human (adult) studies and meta-analyses published in English using search terms ((intensive care OR critical care), AND (sleep OR sleep disorders), AND (light OR noise OR sound)). Bibliographies were explored. Articles were included if reporting change in patient sleep in response to an intervention to reduce disruptive intensive care unit sound /light exposure. Results Fifteen studies were identified. Nine assessed mechanical interventions, four of which used polysomnography to assess sleep. Five studies looked at environmental measures to facilitate sleep and a further two (one already included as assessing a mechanical intervention) studied the use of sound to promote sleep. Most studies found a positive impact of the intervention on sleep. However, few studies used objective sleep assessments, sample sizes were small, methodologies sometimes imperfect and analysis limited. Data are substantially derived from specialist (neurosurgical, post-operative, cardiothoracic and cardiological) centres. Patients were often at the ‘less sick’ end of the spectrum in a variety of settings (open ward beds or side rooms). Conclusions Simple measures to reduce intensive care unit patient sound/light exposure appear effective. However, larger and more inclusive high-quality studies are required in order to identify the measures most effective in different patient groups and any impacts on outcome.
Increasing Medical Trainees’ Empathy Through Volunteerism and Mentorship
Authors: Dussán Kathleen Bronson , Leidal Adam , Corriveau Nicole , Montgomery Daniel , Eagle Kim A , LaHood Barbara J 
Published: November 2017

Background: Within medical education, there have been recent calls for increased understanding and exposure to poverty to increase trainees’ empathy toward the underserved. Students participating in Michigan Cardiovascular Outcomes Research and Reporting Program research program volunteered at World Medical Relief (WMR) in Detroit, Michigan, a nonprofit organization which recycles medical equipment for developing countries and within greater Detroit. Participants’ perceptions of the underserved were measured before and after the experience. Methods: Preliminary questionnaires were given to participants prior to and after exposures at WMR. Questionnaires examined participants’ attitudes toward the underserved, knowledge of medical supply reuse, and their perceived ability to impact change. P values of <.025 were considered significant. Results: A total of 39 participants completed the survey, 77% previously volunteered, 33% had volunteered internationally. Participants were >4× more likely than previously to have knowledge of the variety of recycled medical supplies at WMR. Prior to volunteering, 48.7% of participants gave little thought to how excess medical supplies could be collected versus 0% after exposure. Participants were 1.5× more likely to agree that the experience was enhanced working with their peers and 2.7× more likely to consider starting their own organization/intervention for medical supply donations. Those participants that never previously volunteered were 1.3× more likely to do so with encouragement from a mentor. Conclusions: Encouraging exposure to such service programs resulted in enhanced knowledge of community resources and increased motivation to participate in outreach and belief of individual responsibility to care for the underserved. Incorporating volunteerism into traditional education programs offers the opportunity to build awareness and interest in students reaching out to the underserved.
Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT
Authors: Ho Vincent T. , Kim Haesook T. , Bavli Natalie , Mihm Martin , Pozdnyakova Olga , Piesche Matthias , Daley Heather , Reynolds Carol , Souders Nicholas C. , Cutler Corey , Koreth John , Alyea Edwin P. , Antin Joseph H. , Ritz Jerome , Dranoff Glenn , Soiffer Robert J. 
Published: November 2017

Key PointsGM-K562 admixed leukemia cell vaccination after allogeneic HSCT has biologic activity in MDS/AML. Postvaccination antibody response to angiopoeitin-2 is associated with improved outcomes.