bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: All Inorganic Colloidal Perovskite Quantum Dots: A New Class of Lasing Materials with Favorable Characteristics.
Authors: Wang Yue , Li Xiaoming , Song Jizhong , Xiao Lian , Zeng Haibo , Sun Handong 
Published: January 2016

AbstractCsPbX3 (X: Cl, Br, I) quantum dots are prepared by injecting small amounts of a precursor solution consisting of Cs2CO3, oleic acid (OA), and octadecene (ODE) (150 °C, 1.5 h) to a solution comprising ODE, OA, oleylamine, and PbX2 at 160 °C.
ChemInform Abstract: Color Manipulation of Intense Multiluminescence from CaZnOS:Mn2+ by Mn2+ Concentration Effect.
Authors: Zhang Jun‐Cheng , Zhao Li‐Zhen , Long Yun‐Ze , Zhang Hong‐Di , Sun Bin , Han Wen‐Peng , Yan Xu , Wang Xusheng 
Published: January 2016

AbstractSingle‐phase polycrystalline CaZn1‐xMnxOS (x = 0—0.1) is prepared by solid state reaction of stoichiometric mixtures of CaO, ZnS, and MnCO3 (alumina crucible, 1100 °C, 3 h).
ChemInform Abstract: Switchable Photovoltaic Effects in Hexagonal Manganite Thin Films Having Narrow Band Gaps.
Authors: Han Hyeon , Song Seungwoo , Lee June Ho , Kim Kun Joong , Kim Guan‐Woo , Park Taiho , Jang Hyun Myung 
Published: January 2016

AbstractEpitaxial hexagonal manganite thin films h‐LnMnO3 (Ln: Lu, Y) are grown on a Pt (111) film on Al2O3 (0001) substrate by pulsed laser deposition (850 °C substrate temperature, 1.5 J/cm2, 3 Hz).
ChemInform Abstract: [XeOXeOXe]2+, the Missing Oxide of Xenon(II); Synthesis, Raman Spectrum, and X‐Ray Crystal Structure of [XeOXeOXe][μ‐F(ReO2F3)2]2.
Authors: Ivanova Maria V. , Mercier Helene P. A. , Schrobilgen Gary J. 
Published: January 2016

AbstractThe first xenon(II) oxide, [XeOXeOXe]2+ is synthesized as [F(ReO2F3)2]‐ salt by reaction of ReO3F with XeF2 (molar ratios from ≈1:2 to ≈1:1) in anhydrous HF (FEP reactor, ‐30 °C, 2‐4 h).
ChemInform Abstract: Cu3(SeO4)2(SeO3OH)2 (H2O)16 — The First Example of a Linear Octahedral—Tetrahedral Heptamer in Inorganic Compounds.
Authors: Gurzhiy Vladislav V. , Al‐Shuray Alexander , Britvin Sergey N. , Krivovichev Sergey V. 
Published: January 2016

AbstractSingle crystals of the new copper selenate Cu3(SeO4)2(SeO3OH)2 (H2O)16 are obtained by hydrothermal reaction of an aqueous solution of (UO2)NO3, Cu(NO3)2, and H2SeO4 (autoclave, 180 °C, 72 h) followed by slow solvent evaporation.
ChemInform Abstract: Enantioselective Nickel‐Catalyzed Alkylative Alkyne—Aldehyde Cross‐Couplings.
Authors: Nie Ming , Fu Wenzhen , Cao Ziping , Tang Wenjun 
Published: January 2016

AbstractChiral tetrasubstituted allylic alcohols are prepared in high yields and good to excellent enantioselectivities.
ChemInform Abstract: Disulfonimide‐Catalyzed Asymmetric Reduction of N‐Alkyl Imines.
Authors: Wakchaure Vijay N. , Kaib Philip S. J. , Leutzsch Markus , List Benjamin 
Published: January 2016

AbstractAn axially chiral binaphthyl‐based disulfonimide is synthesized and successfully applied as organo‐catalyst for the enantioselective reduction of N‐alkyl imines with Hantzsch ester.
ChemInform Abstract: Potassium Phosphate—Ionic Liquid Mediated Selective Mono‐Michael Addition.
Authors: Sawant Anand D. , Jagadale Suryabala D. , Desai Uday V. , Salunkhe Manikrao M. 
Published: January 2016

AbstractMono‐Michael addition is observed when active methylene compounds react with compounds with active C—C double bounds in [bmim]Cl/K3PO4 at room temperature.
ChemInform Abstract: An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short‐Lived Intermediates with Planar Chirality.
Authors: Arichi Norihito , Yamada Ken‐ichi , Yamaoka Yousuke , Takasu Kiyosei 
Published: January 2016

Abstract4π‐Electrocyclic ring opening of fused cyclobutanes gives cyclic cis‐trans diene intermediates.
ChemInform Abstract: Three‐Component Azidation of Styrene‐Type Double Bonds: Light‐Switchable Behavior of a Copper Photoredox Catalyst.
Authors: Fumagalli Gabriele , Rabet Pauline T. G. , Boyd Scott , Greaney Michael F. 
Published: January 2016

AbstractThe copper‐catalyzed reaction of indene and styrene with Zhdankin reagent in MeOH in the presence of light gives rise to methoxy azides (III) and (VII), whilst the reaction in the dark leads to diazides (IV)/(V) and (VIII).
ChemInform Abstract: Amino Azaxylylenes Photogenerated from o‐Amido Imines: Photoassisted Access to Complex Spiro‐Poly‐Heterocycles.
Authors: Mukhina Olga A. , Kuznetsov Dmitry M. , Cowger Teresa M. , Kutateladze Andrei G. 
Published: January 2016

AbstractThe intramolecular photocyclization of amino azaxylylenes derived from o‐amido imines, e.g. compounds (I), (IV), and (VII), leads to mixtures of [4 + 4] and [4 + 2] adducts.
ChemInform Abstract: Synthesis, Structural Characterization, and Oxidation Catalysis of a Diniobium‐Substituted Silicodecatungstate.
Authors: Satake Naoto , Hirano Tomohisa , Kamata Keigo , Suzuki Kosuke , Yamaguchi Kazuya , Mizuno Noritaka 
Published: January 2016

AbstractA novel diniobium‐substituted silicodecatungstate is prepared.
ChemInform Abstract: N,N,N′,N′‐Tetramethylenediamine Dioxide (TMEDAO2) Facilitates Atom Economical/Open Atmosphere Ley—Griffith (TPAP) Tandem Oxidation‐Wittig Reactions.
Authors: Read Christopher D. G. , Moore Peter W. , Williams Craig M. 
Published: January 2016

AbstractActivated alcohols are efficiently oxidized under standard Ley—Griffith conditions to aldehydes or ketones, resp., using the title dioxide (TMDD) as the oxidizing agent.
ChemInform Abstract: Cu(II)‐Mediated C(sp2)—H Hydroxylation.
Authors: Sun Shang‐Zheng , Shang Ming , Wang Hong‐Li , Lin Hai‐Xia , Dai Hui‐Xiong , Yu Jin‐Quan 
Published: January 2016

AbstractThe 2‐(oxazolin‐2‐yl)aniline moiety as directing group affords aerial ortho‐hydroxylation of thus derived benzamides.
ChemInform Abstract: Synthesis of α‐Functionalized Trichloromethylcarbinols.
Authors: Ram Ram N. , Soni Vineet Kumar 
Published: January 2016

AbstractSodium trichloroacetate is used in the α‐trichloromethylation of α‐haloalkyl‐ketones, ‐esters, and ‐amides.
ChemInform Abstract: One‐Pot Synthesis of β,β‐Disubstituted α,β‐Unsaturated Carbonyl Compounds.
Authors: Sugiura Masaharu , Ashikari Yasuhiko , Nakajima Makoto 
Published: January 2016

AbstractMethyl alkyl and aryl ketones undergo TiCl4‐mediated aldol reaction in good yields and with high E selectivity.
ChemInform Abstract: Chemoselective Cleavage of P‐Methoxybenzyl and 2‐Naphthylmethyl Ethers Using a Catalytic Amount of HCl in Hexafluoro‐2‐propanol.
Authors: Volbeda Anne Geert , Kistemaker Hans A. V. , Overkleeft Herman S. , van der Marel Gijsbert A. , Filippov Dmitri V. , Codee Jeroen D. C. 
Published: January 2016

AbstractUsing the title reagent, fully protected gluco‐ and mannopyranosides can be selectively Pmb‐ and naphthylmethyl‐cleaved leaving arylthio, methyl‐, benzyl‐, and silyl‐ether functions as well as acetate protective groups unaffected.
ChemInform Abstract: General Ambient Temperature Benzylic Metalations Using Mixed‐Metal Li/K‐TMP Amide.
Authors: Manvar Atul , Fleming Patricia , O'Shea Donal F. 
Published: January 2016

AbstractUsing in‐situ prepared LiNK reagent, methylarenes are sequentially converted into mono‐ and bis‐trimethylsilylated derivatives.
ChemInform Abstract: α‐Lithiated Aryl Benzyl Ethers: Inhibition of [1,2]‐Wittig Rearrangement and Application to the Synthesis of Benzo[b]furan Derivatives.
Authors: Velasco Rocio , Feberero Claudia , Sanz Roberto 
Published: January 2016

AbstractLithiation of aryl benzyl ethers with tBuLi at low temperatures generates stable organolithium intermediates at the benzylic CH2‐group to give a variety of substituted ethers after quenching with electrophiles.
ChemInform Abstract: Copper‐Catalyzed Multi‐Component Synthesis of Acrylamidines and Benzoimidazoles.
Authors: Wang Jinjin , Lu Ping , Wang Yanguang 
Published: January 2016

AbstractAcrylamidines are prepared via copper‐catalyzed three‐component reaction of propargyl acetates, sulfonyl azides, and anilines.
ChemInform Abstract: An Inexpensive and Recyclable Silver‐Foil Catalyst for the Cyclopropanation of Alkenes with Diazoacetates under Mechanochemical Conditions.
Authors: Chen Longrui , Bovee Mark O. , Lemma Betsegaw E. , Keithley Kimberlee S. M. , Pilson Sara L. , Coleman Michael G. , Mack James 
Published: January 2016

AbstractCyclopropanes are diastereoselectively prepared from diazoacetates and styrenes under solvent free conditions in a stainless‐steel ball mill.
ChemInform Abstract: Ultrasound‐Assisted, Convenient and Widely Applicable 1,1′‐Carbonyl‐diimidazole‐Mediated “One‐Pot” Synthesis of Acyl/Sulfonyl Hydrazines.
Authors: Khan Khalid Mohammed , Salar Uzma , Fakhri Muhammad Imran , Taha Muhammad , Hameed Abdul , Perveen Shahnaz , Voelter Wolfgang 
Published: January 2016

AbstractA diverse range of benzoic and sulfonic acid derivatives including biologically and pharmaceutically relevant ones are efficiently transformed into acyl and sulfonyl hydrazines.
ChemInform Abstract: Synthesis of BF3 Catalyzed Mannich Derivatives with Excellent ee from Phenylpropanolamine, Study of Their Antimicrobial Activity and Molecular Docking.
Authors: Chennakesava Rao K. , Easwaramoorthi K. , Arun Y. , Balachandran C. , Muralidhara Rao K. S. , Govindhan M. , Emi Nobuhiko , Prakasam T. , Perumal P. T. 
Published: January 2016

AbstractAntimicrobial agents [(IV) and (VI)] are synthesized with 100% e.e.
ChemInform Abstract: Copper/Manganese Cocatalyzed Oxidative Coupling of Vinylarenes with Ketones.
Authors: Lan Xing‐Wang , Wang Nai‐Xing , Zhang Wei , Wen Jia‐Long , Bai Cui‐Bing , Xing Yalan , Li Yi‐He 
Published: January 2016

AbstractThis method gives access to 1,4‐dicarbonyl compounds from vinylarenes and ketones.
ChemInform Abstract: Synthesis of Passerini Adducts from Aldehydes and Isocyanides under the Auxiliary of Water.
Authors: Li Ming , Qiu Bin , Kong Xiang‐Jing , Wen Li‐Rong 
Published: January 2016

AbstractThis method offers a straightforward access to α‐acyloxycarboxamides with two identical functional groups in high yields.
ChemInform Abstract: Efficient Protocol for the Synthesis of Novel Spiro[acenaphthylene‐1,2′‐pyrrolidin]‐2‐one Compounds.
Authors: Lin Yan , Fu Zhijie , Shen Tianhua , Che Fengfeng , Song Qingbao 
Published: January 2016

Abstract21 Title compounds are prepared by a catalyst‐free 1,3‐dipolar cycloaddition of azomethine ylides formed in situ from (I) and (III) with chalcones (II).
ChemInform Abstract: Divergent Synthesis of α,γ‐Disubstituted γ‐Butyrolactones Through Diastereoselective Bromolactonization with Alkali Metal Bromide: Asymmetric Total Synthesis of (+)‐Dubiusamine C.
Authors: Moriyama Katsuhiko , Sugiue Toru , Nishinohara Chihiro , Togo Hideo 
Published: January 2016

AbstractThe diastereoselective bromolactonization of α‐substituted 4‐pentenoic acids and 4‐pentenamides by oxidative umpolung of bromide ion using alkali metal bromide with Oxone is investigated.
ChemInform Abstract: Recyclable and Reusable [RuCl2(p‐cymene)] 2/Cu(OAc)2/PEG‐400/H2O System for Oxidative C—H Bond Alkenylations: Green Synthesis of Phthalides.
Authors: Zhao Hong , Zhang Tinli , Yan Tao , Cai Mingzhong 
Published: January 2016

AbstractAlkyl acrylates and acrylonitrile react with benzoic acids to give the title compounds in modest to high yields whereby substituents in ortho‐position of the benzoic acids remarkably improve yields independently from their electronic nature.
ChemInform Abstract: An Efficient Microwave‐Assisted Synthesis of Cotinine and Iso‐Cotinine Analogues from an Ugi‐4CR Approach.
Authors: Polindara‐Garcia Luis A. , Montesinos‐Miguel Dario , Vazquez Alfredo 
Published: January 2016

AbstractThe cotinine analogues [e.g. (VI)] are synthesized from 3‐pyridinylaldehydes [e.g. (I)] in two steps under base‐mediated reaction conditions.
ChemInform Abstract: 3‐Naphthylindole Construction by Rhodium(II)‐Catalyzed Regioselective Direct Arylation of Indoles with 1‐Diazonaphthalen‐2‐(1H)‐ones.
Authors: Baral Ek Raj , Lee Yong Rok , Kim Sung Hong 
Published: January 2016

AbstractThe Rh‐catalyzed arylation of indoles (I) with 1‐diazonaphthalenones (II) affords a series of 3‐naphthylindoles (III) in high yields.
ChemInform Abstract: A Facile and Efficient Synthesis of Polycyclic Spiropyrrolidine Oxindoles Bearing Mesityl Oxide Unit via a Three‐Component 1,3‐Dipolar Cycloaddition Reaction.
Authors: Wang Hui‐Juan , Pan Bo‐Wen , Zhang Wen‐Hui , Yang Chao , Liu Xiong‐Li , Zhao Zhi , Feng Ting‐Ting , Zhou Ying , Yuan Wei‐Cheng 
Published: January 2016

AbstractA facile and efficient methodology is developed for the synthesis of multifunctional polycyclic spiropyrrolidine oxindoles via a three‐component 1,3‐dipolar cycloaddition reaction of dienones (III) with azomethine ylides (thermally generated in situ from isatin derivatives and proline or thioproline).
ChemInform Abstract: Diverse Synthesis of Pyrano[2,3‐b]indol and Dihydropyrano[2,3‐b]indol via Tunable Lewis Bases Catalyzed Domino Reactions.
Authors: Liu Yufen , Du Yanlong , Yu Aimin , Qin Dabin , Meng Xiangtai 
Published: January 2016

AbstractTunable domino reactions between methyleneindolones and allenoates are developed leading to pyrano[2,3‐b]indoles with either an E‐ or a Z‐configured ethylidene substituent, or dihydropyrano[2,3‐b]indol.
ChemInform Abstract: Copper(I)‐Catalyzed Kinetic Resolution of N‐Sulfonylaziridines with Indoles: Efficient Construction of Pyrroloindolines.
Authors: Chai Zhuo , Zhu You‐Min , Yang Pei‐Jun , Wang Shaoyin , Wang Shaowu , Liu Zhen , Yang Gaosheng 
Published: January 2016

AbstractA Lewis acid catalyzed [3+2] cycloaddition of indoles and 2‐aryl‐N‐tosylaziridines by using Cu(I)/chiral diphosphine catalysts gives pyrroloindolines with high enantioselectivity under mild conditions.
ChemInform Abstract: Regioselectively Controlled Synthesis of 3(5)‐(Trifluoromethyl)pyrazolylbenzenesulfonamides and Their Effects on a Pathological Pain Model in Mice.
Authors: Zanatta Nilo , et al.  
Published: January 2016

AbstractDepending on the reaction conditions, the reaction of (I) with (II) gives 3‐trifluoromethyl‐pyrazolylbenzenesulfonamides (V) or 5‐trifluoromethyl‐pyrazolylbenzenesulfonamides (IV).
ChemInform Abstract: Aluminum‐Catalyzed Oxazolidinone Synthesis and Their Conversion into Functional Non‐Symmetrical Ureas.
Authors: Laserna Victor , Guo Wusheng , Kleij Arjan W. 
Published: January 2016

AbstractThe Al‐catalyzed reaction of epoxides with phenyl carbamate affords stereoselectively oxazolidinones, which are readily transformed into non‐symmetrical ureas by reaction with amines.
ChemInform Abstract: A Metal‐ and Azide‐Free Multicomponent Assembly Toward Regioselective Construction of 1,5‐Disubstituted 1,2,3‐Triazoles.
Authors: Wan Jie‐Ping , Cao Shuo , Liu Yunyun 
Published: January 2016

AbstractThe title triazoles are regioselectively obtained by three‐component reaction of various enaminones, primary amines, and tosylhydrazine involving a cascade dual C—N bond formation, N—N bond formation and an acyl migration‐based C—C bond formation.
ChemInform Abstract: Tetramethylguanidium‐Based Ionic Liquids as Efficient and Reusable Catalysts for the Synthesis of Biscoumarin at Room Temperature.
Authors: Zhu Anlian , Wang Mingyue , Li Lingjun , Wang Jianji 
Published: January 2016

AbstractTetramethylguanidium acetate is an efficient catalyst for the one‐pot synthesis of biscoumarins.
ChemInform Abstract: Photocatalytic Dehydrogenative Lactonization of 2‐Arylbenzoic Acids.
Authors: Ramirez Nieves P. , Bosque Irene , Gonzalez‐Gomez Jose C. 
Published: January 2016

AbstractThis method provides a general and convenient access to various substituted benzo‐3,4‐coumarins under mild conditions.
ChemInform Abstract: Eco‐Friendly Synthesis of Diverse and Valuable 2‐Pyridones by Catalyst‐ and Solvent‐Free Thermal Multicomponent Domino Reaction.
Authors: Poudel Tej Narayan , Lee Yong Rok , Kim Sung Hong 
Published: January 2016

AbstractA series of functionalized 2‐pyridone derivatives are efficiently and eco‐friendly obtained by multicomponent reaction of several chromene derivatives with 1,3‐diketoesters and various aromatic or aliphatic amines.
ChemInform Abstract: Rh‐Catalyzed Reactions of 3‐Diazoindolin‐2‐imines: Synthesis of Pyridoindoles and Tetrahydrofuropyrroloindoles.
Authors: Wang Chen , Zhang Haojie , Lang Bo , Ren Anni , Lu Ping , Wang Yanguang 
Published: January 2016

AbstractThe title substrates are transformed into α‐imino rhodiumcarbene intermediates which react with furans or tetrahydrofurans to give pyridoindoles and tetrahydrofuropyrroloindoles, respectively.
ChemInform Abstract: Iron(III) Chloride‐Catalyzed Decarboxylative—Deaminative Functionalization of Phenylglycine: A Tandem Synthesis of Quinazolinones and Benzimidazoles.
Authors: Kumar Manoranjan , Richa Manoranjan , Sharma Sushila , Bhatt Vinod , Kumar Neeraj 
Published: January 2016

AbstractA novel procedure is elaborated for the synthesis of quinazolinones (III) from 2‐nitrobenzonitriles (I) and phenylglycines (II).
ChemInform Abstract: Direct Construction of the 9H‐Pyrrolo[1,2‐a]azepin‐9‐amine Skeleton via [4 + 3] Annulation of Alkyl 2‐Aroyl‐1‐chlorocyclopropanecarboxylates.
Authors: Hu Junhao , Liu Yang , Gong Yuefa 
Published: January 2016

AbstractA series of pyrrolo[1,2‐a]azepin‐9‐amines (28 examples) is readily prepared by [4 + 3] annulation of pyrrole imines with chlorocyclopropanes (II).
ChemInform Abstract: Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis Through C—H Activation and Orthogonal Reactivity.
Authors: Demory Emilien , Devaraj Karthik , Orthaber Andreas , Gates Paul J. , Pilarski Lukasz T. 
Published: January 2016

AbstractDirect Ir‐catalyzed C—H arylation of o‐silylaryl triflates offers a regioselective entry to a novel class of (pinacolato)boryl building blocks which can be easily transformed into a wide range of derivatives through functionalization of the boryl substituent or via aryne reactions.
ChemInform Abstract: Ligandless Regioselective Hydrosilylation of Allenes Catalyzed by Gold Nanoparticles.
Authors: Kidonakis Marios , Stratakis Manolis 
Published: January 2016

AbstractA facile protocol using recyclable gold nanoparticles as catalyst renders possible the hydrosilane addition on the more substituted double bond of terminal allenes in a highly regioselective manner.
ChemInform Abstract: Silver‐Catalyzed Direct Csp2‐H Radical Phosphorylation of Coumarins with H‐Phosphites.
Authors: Yuan Jin‐Wei , Li Yuan‐Zhe , Yang Liang‐Ru , Mai Wen‐Peng , Mao Pu , Xiao Yong‐Mei , Qu Ling‐Bo 
Published: January 2016

AbstractThe new direct phosphorylation proceeds in the presence of AgNO3 under mild conditions, affording selective 3‐phosphorylated benzopyran derivatives in moderate to good yields.
ChemInform Abstract: Mizoroki—Heck Reaction of Aryl Halides and Dialkyl Allylphosphonates in Water Catalyzed by Reusable Palladium Nanoparticles.
Authors: Liao Wei‐Ting , Yang Xin‐Jing , Tseng Ya‐Yi , Wu Chien‐Chi , Liu Ling‐Jun , Tsai Fu‐Yu 
Published: January 2016

AbstractVarious aryl‐substituted allylphosphonates are synthesized using commercial PdCl2(NH3)2 as catalyst under aerobic conditions.
ChemInform Abstract: A Novel Sesquiterpene and Three New Phenolic Compounds from the Rhizomes of Acorus tatarinowii Schott.
Authors: Liang Shuang , Ying Shu‐Song , Wu Hong‐Hua , Liu Yan‐Ting , Dong Peng‐Zhi , Zhu Yan , Xu Yan‐Tong 
Published: January 2016

AbstractSesquiterpene named tatarinolactone (I), amides [(II) and (III)], and biphenylpropanoid (IV) are isolated from the rhizomes of title plant.
ChemInform Abstract: Bioactive Steroid Derivatives and Butyrolactone Derivatives from a Gorgonian‐Derived Aspergillus sp. Fungus.
Authors: Chen Min , Wang Kai‐Ling , Liu Min , She Zhi‐Gang , Wang Chang‐Yun 
Published: January 2016

AbstractSix steroid derivatives including the novel, highly conjugated one (I), and five known butyrolactone derivatives are isolated and their structures are elucidated based on NMR and MS data.
ChemInform Abstract: Diversity‐Oriented Synthesis of Analogues of the Novel Macrocyclic Peptide FR‐225497 Through Late Stage Functionalization.
Authors: Mukherjee Jyotiprasad , Sil Suman , Chattopadhyay Shital Kumar 
Published: January 2016

AbstractA concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late‐stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity.
ChemInform Abstract: Organocatalytic Dynamic Kinetic Resolution of Azlactones to Construct Chiral N‐Acyl Amino Acid Oxime Esters.
Authors: Yu Kunru , Liu Xiaohua , Lin Xiaobin , Lin Lili , Feng Xiaoming 
Published: January 2016

AbstractA chiral bisguanidinium salt is applied as a catalyst for the dynamic kinetic resolution of azlactones (I) and (VI) leading to N‐acyl amino acid oxime esters in high yields and excellent enantiomeric excesses (up to 97%).
Herstellung und Charakterisierung von reaktiven Adsorbentien – Untersuchungen zum Reaktionsablauf
Authors: Goldnik Edith , Turek Thomas 
Published: January 2016

AbstractZur Entfernung von Schadgasen aus Umgebungsluft kann eine trockene Abscheidung mit einem Schüttbett aus partikulären Adsorbentien durchgeführt werden. Durch Extrusion wurden Formkörper hergestellt, die als aktive Komponente Kaliumpermanganat enthalten und zur Abscheidung des Modellschadgases H2S dienen. Die Extrudate wurden hinsichtlich ihrer mechanischen Stabilität und der Abscheideleistung mit Durchbruchskurven charakterisiert. Bei diesen Versuchen zeigte sich, dass die Schüttung durchbricht, bevor die Extrudate komplett abreagiert sind. Offenbar kann das Gas während der Reaktion nur langsam in das Extrudat eindringen, so dass die Reaktion hauptsächlich an der äußeren Oberfläche stattfindet.
Boosting Affinity by Correct Ligand Preorganization for the S2 Pocket of Thrombin: A Study by Isothermal Titration Calorimetry, Molecular Dynamics, and High‐Resolution Crystal Structures
Authors: Rühmann Eggert H. , Rupp Melinda , Betz Michael , Heine Andreas , Klebe Gerhard 
Published: January 2016

AbstractStructural preorganization to fix bioactive conformations at protein binding sites is a popular strategy to enhance binding affinity during late‐stage optimization. The rationale for this enhancement relates to entropic advantages assigned to rigidified versus flexible ligands. We analyzed a narrow series of peptidomimetics binding to thrombin. The individual ligands exhibit at P2 a conformationally flexible glycine, more restricted alanine, N‐methylglycine, N‐methylhomoalanine, and largely rigidified proline moiety. Overall, affinity was found to increase by a factor of 1000, explained partly by an entropic advantage. All ligands adopt the same binding mode with small deviations. The residual mobility of the bound ligands is decreased across the series, and a protein side chain differs in its order/disorder behavior along with changes in the surface‐water network pattern established across the newly generated protein–ligand surfaces. The enthalpy/entropy inventory displays a rather complex picture and emphasizes that thermodynamics can only be compared in terms of relative differences within a structurally similar ligand series.