bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Status of the Second Victims of Error and Related Factors in Nurses: A Description Study
Authors: Shahbazzadeh Fardin , Habibi Aghil , Narimani Sajjad , Ajri-Khameslou Mehdi 
Published: October 2024

Abstract

Background
Errors not only affect patients as the primary victim but also have a negative impact on nurses as the secondary victim; therefore, understanding the reasons for the second victim's error, as well as the elements that contribute to this phenomenon, is critical for managing the mistake. The main purpose of this research was to determine the status of second victims of error and related factors in nurses.
Methods
This is an analytical-descriptive study conducted in Iran. five teaching hospitals affiliated with Ardabil University of Medical Sciences. The study's statistical population comprised all nurses working in the teaching hospitals of Ardabil city. A random sampling method was used. The data collection tool included a demographic characteristics questionnaire, a questionnaire on previous nursing error experience characteristics, and the Second Victim Experience and Support Tool. The collected data was analyzed in SPSS-16 software.
Results
The results obtained from this research showed that the average score of second victims of error among nurses participating in the study was 85.89 (10/17). Based on the results obtained, there was a significant relationship between the number of second victims of error phenomena with age (p < 0.01 and r = -0.179) and work experience (p < 0.01 and r = -0.156), the number of cases of errors in 12 previous months, having an error that resulted in injury in the last 12 months, the history of going to court, the way nursing errors were reported, and the way managers dealt with nurses' errors (p < 0.05).
Conclusions
The nurses under study had an average level of the phenomenon of second victims of error, and a set of individual and organizational factors were influential in the development of this phenomenon. Based on this, it was evident that there is a need to utilize the findings of this study to decrease the occurrence of second victims of errors.
Effects of hyper-awareness meditation training on psychological symptom clusters of stroke patients
Authors: Han Lingyu , An Zhaoquan , Shi Hongmei , He Yanling , Li Ruiling 
Published: October 2024

Abstract

This study investigated the effects of hyper-awareness meditation training on psychological symptom clusters in stroke patients. A controlled clinical trial was conducted in which stroke patients were recruited and randomly assigned to a hyper-awareness meditation group and a control group. The psychological symptoms assessed included anxiety, depression, cognition and quality of life levels. Patients in the hyper-awareness meditation group received training sessions focused on this meditation technique, while the control group received standard care with no additional meditation training. A total of 200 patients participated in the study, 100 in each group. Psychological assessments were conducted at baseline, immediately after the end of the intervention, and after 10 days. The results showed that patients in the transcendental awareness meditation group showed significant improvements in psychological symptoms compared to the control group. Anxiety and depression scores decreased significantly and overall psychological well-being improved significantly; thus, hyper-awareness meditation training was found to significantly improve psychological symptoms and reduce stress responses in stroke patients. These findings suggest that incorporating hyper-awareness meditation into a rehabilitation programs for stroke patients may provide significant benefits for mental health and stress management. Further research is recommended to explore the long-term effects of these benefits and their underlying mechanisms.
Coffee consumption and skeletal muscle mass: A Cross-Sectional Study in NHANES 2011-2018
Authors: Zhang Li , Cao Dongdong , Mao Xuemei , Su Jinhong , Lang Huan , Xiao Zifan , Liao Xiaolin , Wang Shuying , Deng Aiqiong 
Published: October 2024

Abstract

Background
The impact of diet on people's health is indisputable. While animal and cell experiments may suggest a link between coffee intake and increased skeletal muscle mass, translating these findings to humans requires careful investigation. The aim of this research is to evaluate the correlation between adult American skeletal muscle mass and caffeine consumption.
Methods
This study was conducted among persons 20 years of age and above between 2011 and 2018, using information from the National Health and Nutrition Examination Survey (NHANES). We investigated the connection between skeletal muscle mass and caffeine intake using three multiple linear regression models. Afterwards, To look into variations in the correlation between caffeine consumption and skeletal muscle mass across several demographic attributes, such as gender, age, race, and body mass index (BMI) categories, subgroup analyses were conducted.
Result
A total of 8,125 participants met the inclusion criteria. All three multiple linear regression models indicated a positive correlation between caffeine intake and skeletal muscle mass. Age-stratified analysis showed significant positive correlations for participants aged 30 to 39 and 40 to 49 years old. BMI-stratified analysis revealed a significant positive correlation between caffeine intake and muscle mass among normal and overweight individuals
Conclusions
Our study results indicate a positive correlation between caffeine intake and muscle mass. Individuals aged 30–49 years and those with a normal or overweight BMI may potentially benefit more. Future cohort studies are necessary to confirm these conclusions and to explore the underlying mechanisms.
Competitive Endogenous RNA Network Associated with Pyroptosis in the Acute Phase of Post Traumatic Brain Injury
Authors: Yulian Zhang , Hanhan Dang , Chuanpeng Zhang , Kun He , Pengyu Chen , Yunsheng Zhang , Zai Wang , Shuangzao Tang , Li Zhang , Yanbing Yu 
Published: October 2024

Abstract

Traumatic brain injury (TBI) is a prevalent neurosurgical condition that can lead to significant disability and mortality. This study investigates the role of long non-coding RNAs (lncRNAs) and pyroptosis in neuroinflammation during the acute phase post-TBI. We analyzed 58 pyroptosis-related genes through mRNA-seq in the injured brain of 33 mice subjected to controlled cortical impact (CCI), organized into 11 groups with different time points (0, 1, 2, 3, 4, 6, 12, 24, 72, 148 hours), including a sham control. Notably, due to the significance of 12-hour time point in the acute inflammatory response, it was selected for whole RNA-seq to profile lncRNA expression, which revealed 540 differentially expressed mRNAs (419 upregulated, 121 downregulated) and 95 lncRNAs (42 upregulated, 53 downregulated). Four key pyroptosis genes (Casp4, Il1a, Il1b, and Il6) were significantly overexpressed. Utilizing the R package “multiMiR” and various databases (“miRDB”, “Starbase” and “LncBase v3.0”), we identified miRNA-mRNA and lncRNA-miRNA interactions, culminating in a pyroptosis-associated competitive endogenous RNA (ceRNA) network comprising 4 lncRNAs, 16 miRNAs, and 4 mRNAs. The 4 lncRNAs and 4 mRNAs showed concordance between the targeted gene expression verified by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and the whole RNA-seq results. Our findings indicate that Casp4-mediated non-canonical pyroptosis may play a critical role during the acute phase following TBI, offering insights into potential therapeutic targets and mechanisms for TBI management.
The association between serum alpha klotho and circadian syndrome: data from NHANES 2007–2016
Authors: Fan Cheng , Huang Shiyuan , Xiang Chunhua , Song Yi 
Published: October 2024

Abstract

Background Circadian syndrome (CircS) is characterized by disrupted circadian rhythm. α-klotho, an anti-aging protein, has garnered particular attention recently. The study aimed to assess the associations of serum alpha klotho and CircS.
Methods Data from National Health and Nutrition Examination Survey (NHANES) 2005-2016 were analyzed. CircS further encompasses sleep disorders and depression, in addition to the components of the metabolic syndrome (MetS). Multivariate logistic regression, subgroup analysis and restricted cubic spline plot were used to analyze the associations.
Results We found a negative relationship between circulating α-klotho and the risk of CircS. Using multivariate logistic regression models, we assessed the association between α-klotho and CircS while adjusting for potential confounders. Compared to the first quartile of klotho, the second quartile group showed 16% decrease in CirS risk (OR=0.84, 95%CI = 0.74-0.96, P = 0.012), and the third quartile group exhibited 21% decrease in CirS risk (OR=0.79, 95%CI = 0.69-0.91, p<0.001) after adjusting all demographic and lifestyle variables. Subgroup analyses revealed significant interactions between α-klotho and alcohol consumption (p=0.008). Additionally, we observed inverse association between α-klotho and odds ratio of CirS in a restricted cubic spline plot.
Conclusion In this large cross-sectional study, our results suggest that higher serum α-klotho levels are significantly associated with a reduced likelihood of circadian syndrome in U.S. adults. Further studies are needed to confirm these findings and elucidate the underlying mechanisms..
Assessing the Rapid Urbanization in Tertiary City of Bangladesh by Land Use and Land Cover Change Detection from 2000 to 2024 through NDVI Based Classification and future forecasting for 2032 by Cellular Automata (CA) model in Meherpur District
Authors: Hossain Md. Ibrahim , Rahman Md. Mostafizur 
Published: October 2024

Abstract

Understanding Land Use and Land Cover (LULC) changes is vital for environmental sustainability, particularly in areas undergoing rapid urban and agricultural transformations. In Meherpur District, Bangladesh, limited research has integrated LULC mapping with predictive models, resulting in a gap in knowledge regarding future land use patterns in this fast-changing region. This study addresses that gap by analyzing LULC changes from 2000 to 2024 using the Normalized Difference Vegetation Index (NDVI), Geographic Information Systems (GIS), and the Cellular Automata (CA) model for predictive analysis. The study reveals significant LULC changes over the 24-year period, including an 18% decrease in vegetation cover, a 6% reduction in agricultural land, and a 4% increase in built-up areas. These trends align with global patterns of urban expansion, often at the expense of agricultural and natural land. Additionally, increases in fallow land (7%) and water bodies (8%) indicate changing land use driven by population growth and infrastructure development. The loss of vegetation, in particular, poses risks to biodiversity, climate regulation, and food security. An innovative aspect of this research is the use of the CA model with the MOLUSCE plugin in QGIS, enabling simulations of future LULC changes up to 2032. This predictive approach offers insights into the impacts of ongoing urbanization, unlike previous studies in Bangladesh that mainly focused on historical LULC changes. The study suggests several future research directions, including investigating the socio-economic drivers of LULC changes, expanding the geographic scope to neighboring regions, and incorporating advanced remote sensing and machine learning techniques to enhance the accuracy of predictions. In conclusion, this research fills a critical gap in LULC studies in Meherpur by combining historical analysis with predictive modeling, offering valuable insights for policymakers to guide sustainable land use planning amidst ongoing urbanization and agricultural development.
Determining Factors of Echocardiographic Changes in Patients With Systemic Lupus Erythematosus: a Cross-sectional Analysis
Authors: Costa Elton Arruda , Silva Gabriel Nunes da , Junior Miguel Luciano Rodrigues da Silva , Lima Matheus Oliveira Assuncao , Silva Lyncoln Eduardo Alves , de Souza Odylon Kleber Pereira , Tozetto David José Oliveira 
Published: October 2024

Abstract

Introduction:
Systemic Lupus Erythematosus is a chronic autoimmune disease that affects multiple organs. Its pathogenesis involves a dysregulated immune response, but the complete mechanisms are not yet fully understood. Chronic inflammation associated with Lupus increases the risk of premature atherosclerosis, leading to cardiovascular events such as myocardial infarction and stroke, which reinforces the importance of preventive strategies to mitigate these risks.
Objectives
This study aimed to identify echocardiographic changes in patients with Systemic Lupus Erythematosus, considering the duration of the disease, the use of medications and comorbidities .
Method
The cross-sectional study was conducted from September 2023 to June 2024, with 22 volunteer patients from the Pará Rheumatic Patients Group (GARPA). Participants completed questionnaires on socioeconomic data and disease history, including time since diagnosis, comorbidities, and medication use. Subsequently, they underwent echocardiographic examinations performed by a single examiner. Statistical analysis was conducted using Fisher's exact test to associate clinical and socioeconomic variables with the observed cardiac changes, with significance set at p ≤ 0.05.
Result
Of the 22 patients studied, 90.9% were women, with a mean age of 40.82 ± 10.79 years. The majority (63.6%) were married, and 54.5% had completed high school. Regarding access to health care, 63.6% used the SUS. The most frequent comorbidities included systemic arterial hypertension (10.7%) and type 2 diabetes mellitus (7.1%), while 35.7% had no comorbidities. The mean time since diagnosis of the disease was 7.0 ± 4.34 years. In terms of medications, the most commonly used were hydroxychloroquine (25%) and prednisone (16.6%). Echocardiograms revealed pulmonary hypertension, mild mitral and aortic insufficiency, in addition to structural alterations such as left ventricular hypertrophy and interatrial septal aneurysm.
Conclusion
The duration of the disease and autoimmune, cardiovascular, musculoskeletal and neurological comorbidities are the main determinants of echocardiographic changes in patients with SLE. On the other hand, the main lines of treatment (antimalarials, corticosteroids and immunosuppressants) were not related to the outcomes.
Knowledge, Attitude and Perception of Sickle Cell Disease, on Premarital Genotype Screening, Among Undergraduate of Al-Hikmah University Ilorin. Nigeria.
Authors: Imam-Fulani Abdulmumeen 
Published: October 2024

Abstract

Genetic compatibility needs to be carefully considered in an effort to lessen the frequency of sickle cell disease (SCD), especially in Nigeria and other African where the disease has a high burden with morbidity and mortality. It has been demonstrated that knowledge of premarital genotype screening PMS, educates individuals about SCD. The descriptive study was aimed to assess the knowledge, attitude and perception of SCD on PMS on selected university student participants. The population for the study are undergraduates, the multi-stage sampling technique was used in sample selection of the 341 respondents, and data was collected using a self-administered questionnaire. Findings indicate 88.3% fell within age range of 18–25 years, 70.1% were female and single, representing 93.5% and a significant proportion. 76% have heard understand SCD and are generally familiar with the complications of SCD. Only 56% have good knowledge of PMS as the cheapest prevention, While 63% don’t know about premarital sickle cell counselling. Only 56% knew their Hemoglobin genotype, however 12% knew Hemoglobin genotype of their fiancés and 69% are of the opinion of terminate relationship if the genotype result is incompatible. 68% support mandatory PMS and the establishment of laws prohibiting marriage in cases of PMS incompatibility. The statistical analysis given that P-value is 0.000, which is < alpha level of 0.05, therefore null hypothesis rejected, It was concluded that knowledge of genetic composition and the potential threat of SCD was robust, mandatory PMS with better counselling strategies, laws to regulate genetic diseases and willingness in advocating PMS to intending couples was confirmed. Recommendations, carrier identification and genetic counselling enlightenment on SCD and PMS testing through mass media and screening centers should be made by the government and religious institutions
Effect of Structured Pre-dialysis Education on the Clinical Outcomes of Kidney Patients
Authors: AYDIN Zehra , OZCAN Seyda 
Published: October 2024

Abstract

Background: The aim of this study was to evaluate the effect of pre-dialysis education on clinical, laboratory, quality of life and self-care ability of patient started dialysis treatment.
Methods: In this observational study we recruited 202 patients. 108 of them were patients who received systematic pre-dialysis education-(education group), 94 patients who were started on dialysis without education (non-education group). Quality of life, self-care, ability, psychological/depressive status, biochemical parameters were evaluated and compared between groups.
Results: The education group had a significantly higher selfcare score (98.3 ± 8.5) (82.4 ± 21.5, p<0.001). The depressive symptoms were lower in the education group (2,8%, 0.9%, and 0.9%; respectively) compared with the non-education group (31.9%,20.2%,2.8%; respectively, p<0.001). Quality of life scale results were significantly higher in the education group than those in the non-education group (p<0.001 for each). Phosphate, parathormone, BUN and residual renal function level was significantly lower (p<0.01) and hemoglobin was significantly higher (p<0.01) in the education group compared to those in the non-education group.
Conclusion: Our study shows that systematic education practices in the pre-dialysis period appear to a associated with improved quality of life, increased self-care ability, increased psychosocial well-being and positive effects on clinical outcomes in dialysis patients.
Evaluating the impact of an educational self-care intervention on the empowerment of primigravida pregnant women covered by family medicine program in the Estahban City—an application of the Pender's health promotion model
Authors: Rezaei Zahra , Asadollahi Abdolrahim , Yazdanpanahi Zahra , Ghahramani Leila 
Published: October 2024

Abstract

Introduction: Pregnancy and childbirth are stages in a woman's life that are associated with many different changes. These changes make normal pregnancy stressful and, if not adequately attended to, can have various irreparable effects on the fetus and the mother. Therefore, this study was conducted with the aim of evaluating the effect of an educational self-care intervention on the empowerment of primigravida pregnant women in the GP program in the city of Estahban. Materials and Methods: The present study was a randomized controlled trial. The sample included 80 pregnant primigravida women with a gestational age of 14–28 weeks. The samples were randomly selected and divided into an intervention group (n = 40) and a control group (n = 40). Six sessions were held for the intervention group; however, the control group received no training. A posttest was conducted 1 month after the educational intervention for both the intervention and control groups. The data were analyzed via 3 questionnaires (demographic data, Kameda Empowerment of Pregnant Women and Self-Assessed Self-Care Empowerment in Pregnancy (SSAP)) and SPSS version 27 as well as chi-square tests, independent t-tests and paired t-tests. Results: One month after the intervention, a significant difference was observed in all the constructs of the Pender health promotion model and empowerment subscales compared to with those of the control group (p < 0.001). In the in-group comparison in the intervention group, although no significant differences were observed in the interpersonal influence structure and future image, social support or joy in addition to the family subscales, the mean scores increased. Conclusion: Self-care interventions based on Pender's health promotion model can increase the ability of pregnant primigravida women to address common problems during pregnancy and thus improve pregnancy outcomes. To achieve significant changes in the interpersonal influence structure and future image, social support and the joy of an addition to the family subscales, more educational sessions, together with their trusted supporters, including their husbands, are emphasized. Trial Id: 73547 IRCT Id: IRCT20131014015015N23
HA198 Mutations in H9N2 Avian Influenza: Molecular Dynamics Insights into Receptor Binding
Authors: Zhu Rui , Wu Jie , Chen Ruiying , Zhou Mo , Cao Shinuo , Wu Zhi , Wang Ligang , Zhang Lei , Zhu Shanyuan 
Published: October 2024

Abstract

The H9N2 avian influenza virus is widely disseminated in poultry and poses a zoonotic threat, despite vaccination efforts. Mutations at residue 198 of hemagglutinin (HA) are critical for antigenic variation and receptor-binding specificity, but the underlying molecular mechanisms remain unclear. This study explores the molecular mechanisms by which mutations at the HA 198 site affect the antigenicity, receptor specificity, and binding affinity of the H9N2 virus. Using the sequence of the A/Chicken/Jiangsu/WJ57/2012 strain, we constructed recombinant H9N2 viruses, including rWJ57, rWJ57/HA198A, and rWJ57/HA198T, using reverse genetics. These variants were analyzed through hemagglutination inhibition (HI) assays, solid-phase receptor binding assays, and enzyme-linked immunosorbent assays (ELISA). Additionally, molecular dynamics (MD) simulations were performed to further dissect the atomic-level interactions between HA and sialic acids (SA). The results showed that HA198V and HA198T mutations enhanced viral binding to human α2,6-linked SA, while HA198A exhibited a preference for avian α2,3 SA. These mutations altered interactions with non-neutralizing antibodies but did not affect neutralizing antibodies, potentially contributing to immune evasion. MD simulations revealed that HA198V/T formed stable complexes with the α2,6 SA, mediated by specific residues and water bridges, whereas HA198A formed stable complexes with the α2,3 SA. Interestingly, residue 198 interacted with the α2,6 SA via water bridges but had minimal direct interaction with the α2,3 SA. This study provides new insights into the molecular basis of receptor specificity, binding affinity, and antigenic drift in H9N2 viruses, highlighting the critical role of HA 198 mutations in regulating host adaptation. These findings are of great significance for H9N2 virus surveillance, vaccine development, and zoonotic transmission risk assessment.