bluuebunny/crossref_metadata_2025_split huggingface dataset:
A development framework for the consultant radiographer in oncology: the Leeds experience
Authors: Roberts Neill 
Published: March 2016

AbstractThe role of the consultant radiographer in radiotherapy is a relatively new concept and to date the number of post holders in these roles remains low. Despite challenges to role creation for the non-medical consultant, the benefits of role development and skill mix within the national health service are evident. Among these challenges is the need to ensure appropriate and credible training of the consultant radiographer. This case study focusses on the local experience of developing a suitable competency framework for the first Consultant Radiographer at the Leeds Cancer Centre. It highlights elements of the framework that equip the post holder to carry out the role and how the governance underpinning such a framework could be used by other radiotherapy centres across the United Kingdom.
Analysis of genetic diversity and structure in a genebank collection of red clover (Trifolium pratenseL.) using SSR markers
Authors: Gupta Mamta , Sharma Vikas , Singh Sunil K. , Chahota Rakesh K. , Sharma Tilak R. 
Published: March 2016

AbstractGenetic diversity of a red clover global collection was assessed using 36 simple sequence repeat (SSR) primers representing all seven linkage groups (LGs). The number of fragments amplified ranged from 1 to 6 for all the primers. Primer RCS0060 detected highest number of fragments, whereas four SSRs viz., RCS0899, RCS1594, TPSSR40 and RCS6927 amplified single fragment. Size range of amplicons generated by all the primers varied from 100 to 400 bp. Polymorphism information content values ranged from 0.301 to 0.719 with an average value of 0.605. LG wise diversity analysis showed that LG 3 was most diverse (I = 0.65, Ht = 0.44), whereas LG-1 showed minimum diversity (I = 0.48, Ht = 0.26) for the microsatellites used. Bayesian model-based clustering inferred three genetically distinct populations in the red clover germplasm holding and showed considerable admixture in individuals within clusters. Neighbour-joining analysis showed intermixing of accessions within groups. Principal component analysis plot complemented the clustering shown by Structure and distinguished three populations to greater extent. Analysis of molecular variance showed that 91% of the genetic variation was residing within populations, while 9% variation was among populations. Overall, the results showed that a high level of genetic diversity is prevailing in this worldwide collection of red clover, which can be exploited for its genetic improvement through breeding approaches.
Feedback regulation of apical progenitor fate by immature neurons through Wnt7–Celsr3–Fzd3 signalling
Authors: Wang Wei , Jossin Yves , Chai Guoliang , Lien Wen-Hui , Tissir Fadel , Goffinet Andre M. 
Published: March 2016

AbstractSequential generation of neurons and glial cells during development is critical for the wiring and function of the cerebral cortex. This process requires accurate coordination of neural progenitor cell (NPC) fate decisions, by NPC-autonomous mechanisms as well as by negative feedback from neurons. Here, we show that neurogenesis is protracted and gliogenesis decreased in mice with mutations of genes Celsr3 and Fzd3. This phenotype is not due to gene inactivation in progenitors, but rather in immature cortical neurons. Mutant neurons are unable to upregulate expression of Jag1 in response to cortical Wnt7, resulting in blunted activation of Notch signalling in NPC. Thus, Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of NPC fate decisions via Notch activation.
Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix
Authors: Nebuloni Manuela , Albarello Luca , Andolfo Annapaola , Magagnotti Cinzia , Genovese Luca , Locatelli Irene , Tonon Giovanni , Longhi Erika , Zerbi Pietro , Allevi Raffaele , Podestà Alessandro , Puricelli Luca , Milani Paolo , Soldarini Armando , Salonia Andrea , Alfano Massimo 
Published: March 2016

AbstractThe extracellular matrix (ECM) from perilesional and colorectal carcinoma (CRC), but not healthy colon, sustains proliferation and invasion of tumor cells. We investigated the biochemical and physical diversity of ECM in pair-wised comparisons of healthy, perilesional and CRC specimens. Progressive linearization and degree of organization of fibrils was observed from healthy to perilesional and CRC ECM and was associated with a steady increase of stiffness and collagen crosslinking. In the perilesional ECM these modifications coincided with increased vascularization, whereas in the neoplastic ECM they were associated with altered modulation of matrisome proteins, increased content of hydroxylated lysine and lysyl oxidase. This study identifies the increased stiffness and crosslinking of the perilesional ECM predisposing an environment suitable for CRC invasion as a phenomenon associated with vascularization. The increased stiffness of colon areas may represent a new predictive marker of desmoplastic region predisposing to invasion, thus offering new potential application for monitoring adenoma with invasive potential.
Maternal Cortisol Mediates Hypothalamus-Pituitary-Interrenal Axis Development in Zebrafish
Authors: Nesan Dinushan , Vijayan Mathilakath M. 
Published: March 2016

AbstractIn zebrafish (Danio rerio), de novo synthesis of cortisol in response to stressor exposure commences only after hatch. Maternally deposited cortisol is present during embryogenesis, but a role for this steroid in early development is unclear. We tested the hypothesis that maternal cortisol is essential for the proper development of hypothalamus-pituitary-interrenal (HPI) axis activity and the onset of the stressor-induced cortisol response in larval zebrafish. In this study, zygotic cortisol content was manipulated by microinjecting antibody to sequester this steroid, thereby making it unavailable during embryogenesis. This was compared with embryos containing excess cortisol by microinjection of exogenous steroid. The resulting larval phenotypes revealed distinct treatment effects, including deformed mesoderm structures when maternal cortisol was unavailable and cardiac edema after excess cortisol. Maternal cortisol unavailability heightened the cortisol stress response in post-hatch larvae, whereas excess cortisol abolished the stressor-mediated cortisol elevation. This contrasting hormonal response corresponded with altered expression of key HPI axis genes, including crf, 11B hydroxylase, pomca, and star, which were upregulated in response to reduced cortisol availability and downregulated when embryos had excess cortisol. These findings for the first time underscore a critical role for maternally deposited cortisol in programming HPI axis development and function in zebrafish.
Phylogenic analysis of adhesion related genes Mad1 revealed a positive selection for the evolution of trapping devices of nematode-trapping fungi
Authors: Li Juan , Liu Yue , Zhu Hongyan , Zhang Ke-Qin 
Published: March 2016

AbstractAdhesions, the major components of the extracellular fibrillar polymers which accumulate on the outer surface of adhesive traps of nematode-trapping fungi, are thought to have played important roles during the evolution of trapping devices. Phylogenetic analyses based on the genes related to adhesive materials can be of great importance for understanding the evolution of trapping devices. Recently, AoMad1, one homologous gene of the entomopathogenic fungus Metarhizium anisopliae cell wall protein MAD1, has been functionally characterized as involved in the production of adhesions in the nematode-trapping fungus Arthrobotrys oligospora. In this study, we cloned Mad1 homologous genes from nematode-trapping fungi with various trapping devices. Phylogenetic analyses suggested that species which formed nonadhesive constricting ring (CR) traps more basally placed and species with adhesive traps evolved along two lineages. Likelihood ratio tests (LRT) revealed that significant positive selective pressure likely acted on the ancestral trapping devices including both adhesive and mechanical traps, indicating that the Mad1 genes likely played important roles during the evolution of nematode-trapping fungi. Our study provides new insights into the evolution of trapping devices of nematode-trapping fungi and also contributes to understanding the importance of adhesions during the evolution of nematode-trapping fungi.
Integrated photonics with programmable non-volatile memory
Authors: Song Jun-Feng , Luo Xian-Shu , Lim Andy Eu-Jin , Li Chao , Fang Qing , Liow Tsung-Yang , Jia Lian-Xi , Tu Xiao-Guang , Huang Ying , Zhou Hai-Feng , Lo Guo-Qiang 
Published: March 2016

AbstractSilicon photonics integrated circuits (Si-PIC) with well-established active and passive building elements are progressing towards large-scale commercialization in optical communications and high speed optical interconnects applications. However, current Si-PICs do not have memory capabilities, in particular, the non-volatile memory functionality for energy efficient data storage. Here, we propose an electrically programmable, multi-level non-volatile photonics memory cell (PMC) fabricated by standard complementary-metal-oxide-semiconductor (CMOS) compatible processes. A micro-ring resonator (MRR) was built using the PMC to optically read the memory states. Switching energy smaller than 20 pJ was achieved. Additionally, a MRR memory array was employed to demonstrate a four-bit memory read capacity. Theoretically, this can be increased up to ~400 times using a 100 nm free spectral range broadband light source. The fundamental concept of this design provides a route to eliminate the von Neumann bottleneck. The energy-efficient optical storage can complement on-chip optical interconnects for neutral networking, memory input/output interfaces and other computational intensive applications.
CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10
Authors: Hessner F. , Dlugos C. P. , Chehab T. , Schaefer C. , Homey B. , Gerke V. , Weide T. , Pavenstädt H. , Rescher U. 
Published: March 2016

AbstractThe superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca2+ binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.
Dust Rains Deliver Diverse Assemblages of Microorganisms to the Eastern Mediterranean
Authors: Itani Ghida Nouhad , Smith Colin Andrew 
Published: March 2016

AbstractDust rains may be particularly effective at delivering microorganisms, yet their biodiversities have been seldom examined. During 2011 and 2012 in Beirut, Lebanon, 16 of 21 collected rainfalls appeared dusty. Trajectory modelling of air mass origins was consistent with North African sources and at least one Southwest Asian source. As much as ~4 g particulate matter, ~20 μg DNA and 50 million colony forming units were found deposited per square meter during rainfalls each lasting less than one day. Sequencing of 93 bacteria and 25 fungi cultured from rain samples revealed diverse bacterial phyla, both Gram positive and negative and Ascomycota fungi. Denaturing Gradient Gel Electrophoresis of amplified 16S rDNA of 13 rains revealed distinct and diverse assemblages of bacteria. Dust rain 16S libraries yielded 131 sequences matching, in decreasing order of abundance, Betaproteobacteria, Alphaproteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, Cyanobacteria, Epsilonproteobacteria, Gammaproteobacteria and Deltaproteobacteria. Clean rain 16S libraries yielded 33 sequences matching only Betaproteobacteria family Oxalobacteraceae. Microbial composition varied between dust rains and more diverse and different microbes were found in dust rains than clean rains. These results show that dust rains deliver diverse communities of microorganisms that may be complex products of revived desert soil species and fertilized cloud species.
Multisite silicon neural probes with integrated silicon nitride waveguides and gratings for optogenetic applications
Authors: Shim Euijae , Chen Yu , Masmanidis Sotiris , Li Mo 
Published: March 2016

AbstractOptimal optogenetic perturbation of brain circuit activity often requires light delivery in a precise spatial pattern that cannot be achieved with conventional optical fibers. We demonstrate an implantable silicon-based probe with a compact light delivery system, consisting of silicon nitride waveguides and grating couplers for out-of-plane light emission with high spatial resolution. 473 nm light is coupled into and guided in cm-long waveguide and emitted at the output grating coupler. Using the direct cut-back and out-scattering measurement techniques, the propagation optical loss of the waveguide is measured to be below 3 dB/cm. The grating couplers provide collimated light emission with sufficient irradiance for neural stimulation. Finally, a probe with multisite light delivery with three output grating emitters from a single laser input is demonstrated.
The Elliott-Yafet theory of spin relaxation generalized for large spin-orbit coupling
Authors: Kiss Annamária , Szolnoki Lénard , Simon Ferenc 
Published: March 2016

AbstractWe generalize the Elliott-Yafet (EY) theory of spin relaxation in metals with inversion symmetry for the case of large spin-orbit coupling (SOC). The EY theory treats the SOC to the lowest order but this approach breaks down for metals of heavy elements (such as e.g. caesium or gold), where the SOC energy is comparable to the relevant band-band separation energies. The generalized theory is presented for a four-band model system without band dispersion, where analytic formulae are attainable for arbitrary SOC for the relation between the momentum- and spin-relaxation rates. As an extended description, we also consider an empirical pseudopotential approximation where SOC is deduced from the band potential (apart from an empirical scaling constant) and the spin-relaxation rate can be obtained numerically. Both approaches recover the usual EY theory for weak SOC and give that the spin-relaxation rate approaches the momentum-relaxation rate in the limit of strong SOC. We argue that this limit is realized in gold by analyzing spin relaxation data. A calculation of the g-factor shows that the empirical Elliott-relation, which links the g-factor and spin-relaxation rate, is retained even for strong SOC.
60 GHz on‐chip mixed coupled BPF with H‐shaped defected ground structures
Authors: Barakat A. , Pokharel R. , Kaho T. 
Published: March 2016

A 60 GHz miniaturised, low loss on‐chip bandpass filter (BPF) based on open‐loop resonators is presented. Overlapping of the BPF's resonators leads to miniaturisation and introduces a mixed coupling configuration. Moreover, its resonators are folded to minimise the size and the insertion loss (IL). H‐shaped defected ground structures are also used to reduce IL and to improve the out of band rejection. The measured IL, return loss, centre frequency, and bandwidth are 2.85 dB, 18 dB, 59 GHz and 15.5 GHz with a chip size of 368 × 262 µm2 including pads.
AlgoRun: a Docker-based packaging system for platform-agnostic implemented algorithms
Authors: Hosny Abdelrahman , Vera-Licona Paola , Laubenbacher Reinhard , Favre Thibauld 
Published: March 2016

Abstract
Motivation: There is a growing need in bioinformatics for easy-to-use software implementations of algorithms that are usable across platforms. At the same time, reproducibility of computational results is critical and often a challenge due to source code changes over time and dependencies.
Results: The approach introduced in this paper addresses both of these needs with AlgoRun, a dedicated packaging system for implemented algorithms, using Docker technology. Implemented algorithms, packaged with AlgoRun, can be executed through a user-friendly interface directly from a web browser or via a standardized RESTful web API to allow easy integration into more complex workflows. The packaged algorithm includes the entire software execution environment, thereby eliminating the common problem of software dependencies and the irreproducibility of computations over time. AlgoRun-packaged algorithms can be published on http://algorun.org, a centralized searchable directory to find existing AlgoRun-packaged algorithms.
Availability and implementation: AlgoRun is available at http://algorun.org and the source code under GPL license is available at https://github.com/algorun
Contact: laubenbacher@uchc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Effect of metal ions on the anti-corrosion properties of γ-glycidoxypropyltrimethoxysilane coatings on cold-rolled iron
Authors: Ge Shengsong , Li Menglong , Shao Qian , Liu Ke , Wang Junxiang , Yi Fengjiao 
Published: March 2016

Purpose
– This paper aims to clarify the effect of metal ions added in the γ-glycidoxypropyltrimethoxysilane (γ-GPS) solutions on the anti-corrosion properties of the γ-GPS coatings on cold-rolled iron (CRI).

Design/methodology/approach
– The transformations of functional groups involved in reactions during the coating process were characterized by Fourier transformed infrared spectroscopy (FTIR), and the thickness of the γ-GPS coatings on the CRI substrates was measured using high-powered microscopy. The anti-corrosion properties of γ-GPS-treated samples were evaluated by neutral salt spray tests, polarization curves and electrochemical impedance spectroscopy measurements.

Findings
– The results show that Zn2+ and Mg2+ in the γ-GPS solutions promote the formation of Si-O-Si and Si-O-Fe bonds and improve the anti-corrosion properties of the γ-GPS coatings on CRI. However, Al3+ and Na+ in the γ-GPS solutions do not play this role.

Originality/value
– Although there have been previous research studies on the γ-GPS coatings on CRI, this paper is the first to study the effect of metal ions added in the silane solutions on the anti-corrosion properties of the γ-GPS coatings, and it has been confirmed that the anti-corrosion properties changed when Zn2+ (or Mg2+) is present.
Workplace diversity management in Australia
Authors: Davis Paul J. , Frolova Yuliya , Callahan William 
Published: March 2016

Purpose
– The purpose of this paper is to identify Australian managers’ attitudes and understandings regarding workforce diversity management (WDM) and the practices and incorporation of WDM in organisations.

Design/methodology/approach
– Methodology is quantitative. A questionnaire in the form of a self-administered survey instrument was mailed to 650 managers (325 HR managers and 325 other managers) in Sydney, Melbourne and Brisbane.

Findings
– The research found that workforce diversity is not especially well understood or appreciated; especially by non-HR managers. Organisations appear generally not to prioritise WDM and levels of senior manager engagement with the topic are tentative. Statistical analysis highlighted considerable divergence of opinion across the surveyed group.

Research limitations/implications
– As an exploratory study, further research is encouraged to better understand cause and effect relationships pertaining to the findings.

Practical implications
– There are implications for HR managers or those in related roles who might design, implement and promote WDM initiatives. There are implications for consultants, employees and senior managers regarding education, awareness and support of diversity objectives.

Originality/value
– Addresses a gap in the literature by looking at contemporary attitudes and practices regarding WDM in Australian organisations. Provides the first empirical comparison between HR and other managers on the topic.
Reflexivity in managing diversity: a pracademic perspective
Authors: Bouten-Pinto Carolina 
Published: March 2016

Purpose
– The purpose of this paper is to propose reflexivity as a means to managing diversity practice in organizations. Reflexivity enables taken for granted assumptions about identities, roles, perspectives, language, meanings and understandings between managers and employees to be explored and redefined in ways that matter to the people in the workplace. It provides insights and examples from a practitioner perspective while engaged in designing and implementing a managing diversity initiative. In addition, it positions the development of relationships between managers and employees as a key ingredient in managing diversity.

Design/methodology/approach
– This paper is based on a post hoc qualitative reflexive study of a managing diversity project undertaken by the author as a diversity practitioner.

Findings
– The study suggested that reflexivity can allow both managers and employees to critically examine the conventional ways in which diversity and differences are understood, as this awareness can enable more relational approaches to diversity to be developed.

Research limitations/implications
– Because of the chosen qualitative research approach, the specific findings cannot be generalized; rather, an example of the potential of reflexivity as practice in organizations is proffered and insights are offered to enable further academic enquiry and practical considerations.

Practical implications
– Reflexivity stimulates both independent and shared action-learning sense-making processes which support equal participation. This challenges and expands the diversity agendas prevalent in the applied field of managing diversity. For example, by positioning organizational diversity as an inter-subjective and contextual process, meaningful dialogue between employees and managers becomes possible. Moreover, as reflexivity allows for a range of narrative accounts to emerge from such embedded activities, this approach can serve as a model for similar dialogical processes to occur within the wider organization. In addition, this paper provides insight into how reflexivity as practice for both practitioners and researchers can offer a means for more collaborative relationships to develop at the practitioner/researcher nexus.

Originality/value
– The paper endeavors to make a contribution to both the academic and the practitioner managing diversity fields by demonstrating that reflexive practice can add significant value to managing diversity processes in organizations and research.
The ethics pipeline to academic publishing
Authors: Bertram Gallant Tricia 
Published: March 2016

Purpose
– This paper aims to respond to Curno’s piece on the Challenges to ethical publishing in the digital era.

Design/methodology/approach
– In this response, the author argues that a focus on “publication ethics” may perpetuate the problem of unethical conduct because such a focus ignores the influences of the educational ethics pipeline.

Findings
– As a result, the author issues two calls for action: we must cease operating in our ethical silos and educational leaders must publicly recognize the problem of unethical conduct and fully commit to addressing it.

Originality/value
– This response challenges the notions of ethical silos and the inaction by educational institutions to properly train ethical professionals, authors and researchers.