bluuebunny/crossref_metadata_2025_split huggingface dataset:
VISUALIZATION OF MACULAR PUCKER BY MULTICOLOR SCANNING LASER IMAGING
Authors: Kilic Muftuoglu Ilkay , Bartsch Dirk-Uwe , Barteselli Giulio , Gaber Raouf , Nezgoda Joseph , Freeman William R. 
Published: February 2017

Purpose:
To compare the visualization of the epiretinal membrane (ERM) using multicolor imaging (MCI) (Heidelberg Engineering, Carlsbad, CA) and conventional white light flood color fundus photography (FP) (Topcon).

Methods:
The paired images of patients with ERM who underwent same-day MCI and FP examinations were reviewed. Visibility of the ERM was graded using a scale (0: not visible, 1: barely visible, and 2: clearly visible) by masked readers, and surface folds were counted to quantify the membrane visibility for each method. Images from individual color channels in MCI (green, blue, and infrared) were also graded using the same method to further investigate MCI images.

Results:
Forty-eight eyes of 42 patients were included. The average ERM visibility score was 1.8 ± 0.37 for MCI and 1.01 ± 0.63 for FP (P < 0.001). The number of the surface folds detected per quadrant was signifi8cantly higher in MCI than that in FP (6.79 ± 3.32 vs. 2.85 ± 2.81, P < 0.001). The ERM was graded with similar scores on the two modalities in 43.8% of the eyes; in 56.2%, the ERM was better visualized on MCI than that on FP. Conventional FP failed to detect ERM in 11.4% of eyes when the mean central retinal thickness was <413 microns. Analysis of laser color reflectance revealed that green reflectance provided better detection of surface folds (5.54 ± 2.12) compared to blue reflectance (4.2 ± 2.34) and infrared reflectance (1.2 ± 0.9).

Conclusion:
Multicolor scanning laser imaging provides superior ERM detection and delineation of surface folds than conventional FP, primarily due to the green channel present in the combination-pseudocolor image in MCI.
RETINAL BLOOD FLOW AFTER INTRAVITREAL BEVACIZUMAB IS A PREDICTIVE FACTOR FOR OUTCOMES OF MACULAR EDEMA ASSOCIATED WITH CENTRAL RETINAL VEIN OCCLUSION
Authors: Matsumoto Makiko , Suzuma Kiyoshi , Yamada Yoshihisa , Tsuiki Eiko , Fujikawa Azusa , Kitaoka Takashi 
Published: February 2017

Purpose:
To investigate whether retinal blood flow levels after intravitreal bevacizumab (IVB) treatment are correlated with the outcomes of patients with macular edema secondary to central retinal vein occlusion.

Methods:
This retrospective observational case study enrolled 44 cases nonischemic central retinal vein occlusion. In each patient, visual acuity, central retinal thickness, and mean blur rate, which was measured by laser speckle flowgraphy and represents retinal blood flow velocity, were examined.

Results:
At the end of the follow-up period (19.8 ± 8.8 months), 4 of 44 eyes (9.1%) converted to the ischemic type (converted group), whereas 40 (90.9%) remained unchanged (nonischemic group). Mean central retinal thickness significantly decreased and mean visual acuity significantly improved at 1 month after the first IVB injection in each group. Mean mean blur rate in the nonischemic group significantly increased, whereas it was unchanged in the converted group. The difference between the two groups was already significant after the first IVB injection. Subsequently, visual acuity worsened in the converted group. Multiple linear regression analysis indicated that the strongest correlation was between the last visual acuity and the last mean blur rate.

Conclusion:
Blood flow measurements are useful for evaluating IVB treatments. Blood flow after IVB can predict outcomes in patients with central retinal vein occlusion.
QUANTITATIVE ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN ADULT-ONSET FOVEOMACULAR VITELLIFORM DYSTROPHY
Authors: Battaglia Parodi Maurizio , Rabiolo Alessandro , Cicinelli Maria Vittoria , Iacono Pierluigi , Romano Francesco , Bandello Francesco 
Published: February 2017

Purpose:
To quantify the foveal avascular zone area at superficial capillary plexus (SCP) and deep capillary plexus (DCP) and the global, parafoveal, and perifoveal vessel densities at SCP, DCP, and choriocapillaris using optical coherence tomography angiography in patients affected by adult-onset foveomacular vitelliform dystrophy (AOFVD).

Methods:
Twenty eyes of 20 consecutive patients (10 females, 50%) with AOFVD and 20 eyes of 20 healthy controls presenting at the Department of Ophthalmology of San Raffaele Hospital, Milan, Italy were enrolled. All patients underwent a complete ophthalmic examination, including 3-mm × 3-mm optical coherence tomography angiography centered on the macula. The vessel density was calculated in the three plexuses (i.e., SCP, DCP, and choriocapillaris) by mean of image binarization, and foveal avascular zone area was manually outlined at SCP and DCP with ImageJ software.

Results:
In the SCP, patients with AOFVD disclosed a significant reduction of global (P < 0.001), parafoveal (P = 0.0017), and perifoveal (P = 0.0019) vessel density. In the DCP, parafoveal vessel density was higher in patients with AOFVD (P = 0.0026), whereas no significant difference was appreciated for both the global image (P = 0.5) and the perifoveal area (P = 0.5). Patients with AOFVD showed less dense choriocapillaris (P = 0.012) and perifoveal circle (P = 0.0152), whereas no difference was observed in the perifoveal zone (P = 0.07). Foveal avascular zone area was significantly enlarged at the DCP (P = 0.0184), but not at the SCP.

Conclusion:
Patients with AOFVD have quantitative vascular alterations in all vascular layers.
PREDICTIVE FACTORS FOR DEVELOPMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Authors: Fragiotta Serena , Rossi Tommaso , Cutini Alessandro , Grenga Pier L. , Vingolo Enzo M. 
Published: February 2017

Purpose:
To investigate the risk factors predictive for the development of neovascular age-related macular degeneration (NVAMD) by means of spectral-domain optical coherence tomography.

Methods:
Retrospective study of 73 eyes graded Stage 2 and Stage 3 according to the AMD International Grading System with minimum follow-up of 24 months. Drusenoid pigment epithelial detachment, hyperreflective foci, external limiting membrane, inner ellipsoid band, and retinal pigment epithelium integrity were analyzed at baseline and last follow-up. Binary logistic regression model analyzed significant predictors of neovascular conversion.

Results:
The discontinuity of external limiting membrane, inner ellipsoid band, and retinal pigment epithelium bands were significantly more prevalent in the NVAMD group at baseline and last follow-up (P < 0.001). Hyperreflective foci represented the single most important predictor of neovascular conversion (Exp [B], 15.15; P = 0.005) as confirmed by Kaplan–Meier curve (P = 0.002). Drusenoid pigment epithelial detachment width was significantly greater in NVAMD group than control subjects at baseline and last follow-up (P < 0.001), and its delta value also resulted a significant neovascular predictor (Exp [B], 0.99; P = 0.04).

Conclusion:
Hyperreflective foci significantly increase the risk of NVAMD progression. The delta width of drusenoid pigment epithelial detachment also predicts disease progression, integrating the stratification of NVAMD progression risk.
RETINAL CAPILLARY DENSITY IN PATIENTS WITH BIRDSHOT CHORIORETINOPATHY
Authors: Roberts Philipp K. , Nesper Peter L. , Goldstein Debra A. , Fawzi Amani A. 
Published: February 2017

Purpose:
To quantify retinal capillary density and determine its correlation with visual acuity in patients with birdshot chorioretinopathy (BCR).

Methods:
Patients with BCR and age-matched controls were imaged using a commercially available spectral domain optical coherence tomography angiography system (RTVue- XR Avanti; Optovue, Inc). We used the integrated software of the optical coherence tomography angiography device to analyze the foveal avascular zone area and the capillary density in the full retina as well as in the superficial capillary plexus and deep capillary plexus. We assessed the correlation between these parameters and visual acuity.

Results:
Seventy-four eyes of 42 study participants (37 eyes of 21 BCR and 37 eyes of 21 healthy subjects) were included in this observational cross-sectional study. Capillary density of the full retina, superficial capillary plexus, and deep capillary plexus were significantly decreased in BCR compared with the healthy control group (P < 0.01). Visual acuity in patients with BCR was significantly associated with the capillary density of the superficial capillary plexus, deep capillary plexus, and full retina (P < 0.01) but not with the area of the foveal avascular zone.

Conclusion:
The decrease in visual acuity in patients with BCR is associated with retinal vascular impairment. Vessel density of the retinal capillary plexuses may be a promising imaging biomarker for BCR disease severity.
IS A POSTOPERATIVE DAY ONE EXAMINATION NEEDED AFTER UNCOMPLICATED VITREORETINAL SURGERY?
Authors: Zick Jon , Joondeph Brian C. 
Published: February 2017

Purpose:
To determine whether there were any adverse consequences from seeing vitreoretinal surgery patients on the second rather than the first postoperative day.

Methods:
A retrospective review of vitreoretinal surgical patients from a single surgeon seen on the second, but not the first day after surgery. Preoperative, intraoperative, and postoperative findings were recorded with attention to adverse or safety events.

Results:
One hundred thirty-four patients were identified, representing a variety of vitreoretinal pathology and surgical procedures. All patients received a technician phone call on the first postoperative day inquiring about pain and vision. Six patients had an intraocular pressure over 30 on the second postoperative day, all managed medically. Only one patient was seen on the first postoperative day because of pain and elevated pressure. There were no cases of endophthalmitis.

Conclusion:
Postoperative vitreoretinal surgical patients can reasonably be seen on the second postoperative day, when logistics dictate, allowing them to be seen by their operative surgeon in a more convenient location.
ASSOCIATION BETWEEN TANGENTIAL CONTRACTION AND EARLY VISION LOSS IN IDIOPATHIC EPIRETINAL MEMBRANE
Authors: Lee Seung Min , Pak Kang Yeun , Kwon Han Jo , Park Sung Who , Lee Ji Eun , Byon Ik Soo 
Published: February 2017

Purpose:
To investigate the clinical features associated with early visual loss in patients with idiopathic epiretinal membrane.

Methods:
Patients with idiopathic epiretinal membrane with visual acuity of ≥20/40, intact ellipsoid zone, and follow-up duration of at least 24 months were included in this retrospective age-matched control study. The disk–fovea–vascular (DFV) distance, central macular thickness, membrane configuration, and ellipsoid zone were assessed using fundus photography and spectral domain optical coherence tomography.

Results:
We analyzed the progression group (n = 15; vision loss ≥2 lines because of membrane progression) and the control group (n = 30; age matched). Compared with the controls, the mean DFV distance decreased (P < 0.001), central macular thickness increased (P = 0.017), and the ratio of the follow-up and baseline DFV distances (traction index of membrane) was significantly lower (P = 0.001) in the progression group. No differences were observed in the follow-up membrane configuration and ellipsoid zone. Factors associated with early vision loss were the DFV distance change (ρ = 0.657; P = 0.008) and traction index of membrane (ρ = −0.636; P = 0.011). Their area under receiver-operating characteristic curves were significant (DFV distant change: 0.915, traction index of membrane: 0.910, respectively; P < 0.001, both).

Conclusion:
Assessing the DFV distance is useful in quantifying the tangential contraction of macula and the prediction of vision loss in idiopathic epiretinal membrane.
THERAPEUTIC OUTCOMES AFTER ENDORESECTION OF COMPLEX RETINAL CAPILLARY HEMANGIOBLASTOMA
Authors: Karacorlu Murat , Hocaoglu Mumin , Sayman Muslubas Isil , Ersoz Mehmet Giray , Arf Serra 
Published: February 2017

Purpose:
To evaluate the anatomical and functional outcomes after endoresection of complex retinal capillary hemangioblastoma (RCH).

Methods:
Retrospective case series of 12 patients (13 eyes), all treated with pars plana vitrectomy, endodiathermy of feeding and draining vessels, endoresection of RCH and silicone oil injection.

Results:
The mean age at the time of surgery was 32.5 ± 15.9 years. The mean follow-up duration after initial surgery was 50.5 ± 49.4 months. Indications for surgery included RCH with associated complications such as tractional retinal detachment in five eyes (38%), exudative retinal detachment in four eyes (31%), and combination of tractional retinal detachment and exudative retinal detachment in four eyes (31%). The dimensions of the resected RCHs were as follows: >3.0 mm in seven eyes (54%), >3.5 mm in three eyes (23%), and >4.0 mm in three eyes (23%). No tumor was located closer than 10 mm to the optic nerve or fovea. Anatomical success after initial surgery was 92%. One eye had a second vitreoretinal procedure owing to recurrent RD. The mean preoperative Snellen visual acuity was 20/303. The mean Snellen visual acuity at the final visit was 20/73. At the final visit, visual acuity had improved in seven eyes (54%), and six eyes (46%) were stable. Short-term complications included recurrent proliferative vitreoretinopathy in one eye (8%), transient ocular hypertension requiring topical antiglaucoma treatment in four eyes (31%), and long-term complications included progression of cataract in seven eyes (54%).

Conclusion:
Combined pars plana vitrectomy, endodiathermy of feeding and draining vessels, endoresection of RCH, and silicone oil injection may be an effective treatment option for complex RCH, achieving high anatomical success and stable or even improved visual acuity, acceptable rates of disease- and treatment-related complications, and minimal need for retreatment.
GRAM-NEGATIVE BACTERIA FROM PATIENTS WITH ENDOPHTHALMITIS: DISTRIBUTION OF ISOLATES AND ANTIMICROBIAL SUSCEPTIBILITIES
Authors: Wilson Benjamin D. , Relhan Nidhi , Miller Darlene , Flynn Harry W. 
Published: February 2017

Purpose:
To study the distribution of isolates and antimicrobial susceptibility of gram-negative bacteria among culture-positive vitreous samples from patients with endophthalmitis.

Methods:
The records from culture-positive vitreous isolates (endophthalmitis cases) during a 24-year period (December 1990 to December 2014), at the Microbiology Department of Bascom Palmer Eye Institute were reviewed.

Results:
In the current study, gram-negative bacteria were reported in 246 (11.5%) of 2,134 vitreous isolates from endophthalmitis patients during 24-year period (December 1990 to December 2014) from a University Referral Center. The antimicrobial susceptibility to fluoroquinolones, aminoglycosides, carbapenems, and ceftazidime remained stable among gram-negative bacteria during the study period.

Conclusion:
Antibiotic susceptibility pattern of gram-negative bacteria from vitreous isolates did not change significantly during the 24-year study period.
RELATION BETWEEN FLUORESCEIN ANGIOGRAPHIC AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF BLOOD FLOW TURBULENCE AT ARTERIOVENOUS CROSSINGS IN THE RETINA
Authors: Willerslev Anne , Li Xiao Qiang , Munch Inger Christine , Larsen Michael 
Published: February 2017

Purpose:
To examine retinal blood flow at arteriovenous crossings using spectral-domain optical coherence tomography (SD-OCT).

Methods:
Retrospective observational case series of 11 arteriovenous crossings in 10 eyes examined by SD-OCT and fluorescein angiography on suspicion of manifest or imminent branch retinal vein occlusion.

Results:
Fluorescein angiographic evidence of turbulence was seen at 5 of 11 arteriovenous crossings, whereas laminar angiographic flow was intact at the crossing and downstream thereof at the remaining 6 crossings. On SD-OCT, chaotic reflectivity patterns were seen at the point of crossing and downstream thereof in all 5 cases with angiographic turbulence, whereas an intravascular trilayer SD-OCT pattern consistent with laminar flow was seen throughout the examined course of the vein in the eyes with laminar angiographic flow.

Conclusion:
We examined retinal blood flow at and near arteriovenous crossings and found that SD-OCT may rival fluorescein angiography in the ability to demonstrate turbulent venous blood flow.
CLINICAL PATHOLOGIC CORRELATION OF SARCOIDOSIS-ASSOCIATED MULTIFOCAL CHORIORETINITIS IN AN ELDERLY PATIENT
Authors: Saleh Mohamed G. A. , O'Donnell John L. , Davis Ronald P. , Wilson David , Lin Phoebe 
Published: February 2017

Background/Purpose:
To describe a case of histopathologic clinical correlation of sarcoidosis-related multifocal chorioretinitis in an elderly individual.

Methods:
This is a single case report and review of the pertinent literature. A 72-year-old white woman with a history of asthma was referred with bilateral asymmetric low-grade chronic panuveitis with advancing peripheral punched-out chorioretinal lesions despite systemic corticosteroid treatment.

Results:
Coalescent chorioretinal punched-out lesions on fundus examination in the more severely affected right eye did not respond to corticosteroid treatment, and the refractory nature resulted in a suspicion of intraocular lymphoma despite a previous inconclusive diagnostic vitrectomy result. A transvitreal chorioretinal biopsy in the vitrectomized eye demonstrated a chorioretinal noncaseating granuloma centered on the choriocapillaris and invading Bruch membrane and the outer retina. This case illustrates an example of the second peak of incidence in sarcoidosis that can occur in ages >50 in Caucasians and Japanese patients, as well as a tendency to develop chronic disease in Caucasians, and to have extrapulmonary sarcoidosis in the elderly.

Conclusion:
This case emphasizes the differences in presentation of ocular sarcoid in older Caucasian women as well as the histopathologic findings in multifocal peripheral chorioretinitis associated with sarcoidosis.
CLINICAL FEATURES IN A CASE OF OCCULT MACULAR DYSTROPHY WITH RP1L1 MUTATION
Authors: Fu Yun , Chen Kuan-Jen , Lai Chi-Chun , Wu Wei-Chi , Wang Nan-Kai 
Published: February 2017

Purpose:
To investigate appropriate diagnostic testing for occult macular dystrophy (OMD) in a patient with unexplained progressive visual loss.

Methods:
Observational case report.

Results:
Occult macular dystrophy is an uncommon autosomal dominant macular disease, but sporadic occurrences have been noted. We report a patient with progressive visual decline, but with normal findings in fundus photography, visual field, fluorescein angiography, and full-field standard electroretinography. Direct sequencing of the RP1L1 gene showed a c. 133C>T mutation, which confirmed the diagnosis of OMD genetically. The only two ocular examinations that can show abnormal findings in such cases are spectral domain optical coherence tomography and multifocal electroretinography. Therefore, spectral domain optical coherence tomography and multifocal electroretinography are very important in making a diagnosis of OMD before applying expansive techniques such as brain computed tomography or magnetic resonance imaging.

Conclusion:
Spectral domain optical coherence tomography and multifocal electroretinography can serve as diagnostic testings for patients with OMD.
Clinical Significance of Arterial Stiffness and Metabolic Syndrome Scores in Vestibular Neuritis
Authors: Chung Jae Ho , Lee Seung Hwan , Park Chul Won , Jeong Jin Hyeok , Shin Jeong-Hun 
Published: February 2017

Objective:
To investigate the clinical significance of cardiovascular factors, including arterial stiffness and metabolic syndrome scores, in the development of vestibular neuritis.

Study Design:
A prospective, case-control study.

Setting:
Tertiary referral center.

Patients:
Fifty-eight adult patients with vestibular neuritis (VN) and 58 age- and sex-matched controls were evaluated between January 2015 and January 2016.

Intervention:
Measurement of arterial stiffness.

Main Outcome Measures:
Arterial stiffness was assessed from brachial-ankle pulse wave velocity (baPWV), and cardiovascular markers including blood pressure, body mass index and lipid profiles, and metabolic syndrome scores were determined. The dizziness handicap inventory (DHI) and vestibular function tests, including the caloric test and video head impulse test were evaluated. The correlations between cardiovascular factors and clinical parameters of VN were assessed.

Results:
Blood pressure, baPWV, and metabolic syndrome scores were higher in the VN group than in the control group (p = 0.002, p = 0.001, and p = 0.001, respectively), whereas comorbidity, anthropometric characteristics, and lipid profiles did not differ significantly. baPWV and metabolic syndrome scores were not correlated with the clinical parameters of the DHI scores, canal paresis, and spontaneous nystagmus duration. In addition, cardiovascular factors did not associate with the vestibular compensation.

Conclusions:
Higher baPWV, representative of arterial stiffness, and higher metabolic syndrome scores, are associated with the development of VN. This supports the hypothesis of a vascular etiology of the disease. However, cardiovascular risk factors had limited value in predicting the clinical course of VN.
Efficacy of Bone-Anchored Hearing Aids in Single-Sided Deafness: A Systematic Review
Authors: Kim Gaeun , Ju Hyun Mi , Lee Sun Hee , Kim Hee-Soon , Kwon Jeong A. , Seo Young Joon 
Published: February 2017

Objectives:
Bone-anchored hearing aids (BAHAs) have been known to partially restore some of the functions lost in subjects with single-sided deafness (SSD). Our aims in this systemic review were to analyze the present capabilities of BAHAs in the context of SSD, and to evaluate the efficacy of BAHAs in improving speech recognition in noisy conditions, sound localization, and subjective outcomes.

Design:
A systematic search was undertaken until August 2015 by two independent reviewers, with disagreements resolved by consensus. Among 286 references, we analyzed 14 studies that used both subjective and objective indicators to assess the capabilities of a total of 296 patients in the unaided and aided situations.

Results:
Although there was “no benefit” of BAHA implantation for sound localization, BAHAs certainly improved subjects’ speech discrimination in noisy circumstances. In the six studies that dealt with sound localization, no significant difference was found after the implantation. Twelve studies showed the benefits of BAHAs for speech discrimination in noise. Regarding subjective outcomes of using the prosthesis in patients with SSD (abbreviated profile of hearing aid benefit [APHAB] and the Glasgow hearing aid benefit profile [GHABP], etc.), we noticed an improvement in the quality of life.

Conclusions:
This systematic review has indicated that BAHAs may successfully rehabilitate patients with SSD by alleviating the hearing handicap to a certain degree, which could improve patients’ quality of life. This report has presented additional evidence of effective auditory rehabilitation for SSD and will be helpful to clinicians counseling patients regarding treatment options for SSD.