bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postmarketing Safety Events Relating to New Drugs Approved in Brazil Between 2003 and 2013: A Retrospective Cohort Study
Authors: Botelho Stephanie Ferreira , Martins Maria Auxiliadora Parreiras , Vieira Liliana Batista , Reis Adriano Max Moreira 
Published: August 2016

AbstractThis study investigated postmarketing safety events (PMSEs) for new drugs approved in Brazil and evaluated whether a range of drug characteristics influenced the time between approval and the first PMSE. This retrospective study included new drugs registered between 2003 and 2013 by the National Health Surveillance Agency (ANVISA), which is responsible for medicines approval in Brazil. PMSEs were defined as any drug safety alert or drug withdrawal from the market. The existence of risk evaluation and mitigation strategies (REMS) by the US Food and Drug Administration (FDA) and Brazil were recorded. A Kaplan‐Meier survival curve of the period between the date of ANVISA registration and the PMSE was calculated. We found a statistically significant difference between the time to PMSE for drugs with an FDA REMS compared with those without a REMS, with a log rank value (Mantel Cox) of 0.002. There was no association between the time to PMSE and the other drug characteristics investigated. This study demonstrated that the frequency of PMSEs for new drugs approved by ANVISA was statistically associated with the existence of an FDA REMS. The time between approval and first PMSE was shorter for drugs with an FDA REMS, and this finding may contribute to improved awareness of the risk/benefit balance required to ensure continued safe and effective use of new drugs.
Reference values of cardiac volumes, dimensions, and new functional parameters by MR: A multicenter, multivendor study
Authors: Aquaro Giovanni Donato , Camastra Giovanni , Monti Lorenzo , Lombardi Massimo , Pepe Alessia , Castelletti Silvia , Maestrini Viviana , Todiere Giancarlo , Masci Piergiorgio , di Giovine Gabriella , Barison Andrea , Dellegrottaglie Santo , Perazzolo Marra Martina , Pontone Gianluca , Di Bella Gianluca ,   On behalf of the working group “Applicazioni della Risonanza Magnetica” of the Italian Society of Cardiology
Published: August 2016

PurposeTo define reference values of cardiac volumes, dimensions, and new morpho‐functional parameters normalized for age, gender, and body surface area by cine‐bSSFP (balanced steady‐state free‐precession) magnetic resonance (MR).Materials and MethodsWe enrolled 308 healthy subjects subdivided by gender and by six age classes: class I, >15–20 years; class II, >20–30 years; class III, >30–40 years; class IV, >40–50 years; class V, >50–60 years; and class VI >60 years. Dimensional, volumetric and morpho‐functional parameters of the left (LV) and right (RV) ventricles were measured using cine‐bSSFP MRI at 1.5T.ResultsThe LV and RV end‐diastolic volume indexes (EDVi) were inversely related to age (P < 0.0001 r = –0.34 and P < 0.0001 r = –0.37, respectively). In addition, the LV mass index decreased with age (P = 0.0004, r = –0.21). The LV longitudinal shortening was not significantly different among groups: ≥15% in all populations (95% confidence interval [CI]: 16–31). The sphericity index measured in end‐diastole was higher in females than in males (P < 0.03): the upper limit was 40% for males and 42% for females. The normality cutoff of LV global function index was ≥33% in males and ≥35% in females. The end‐diastolic volume (EDV) of RV and LV was balanced (RV/LV ratio 0.85–1.15) without differences in the population. The LV EDV/mass was 1.0–1.8 in males and 1.0–2.1 in females.ConclusionThis study provides potential age‐ and gender‐specific reference.Level of Evidence: 2J. Magn. Reson. Imaging 2017;45:1055–1067
Palmyra palm (Borassus aethiopum Mart.) fruits: novel raw materials for the pectin industry
Authors: Assoi Sylvie , Konan Koffi , Agbo Georges N , Dodo Hortense , Holser Ron , Wicker Louise 
Published: August 2016

AbstractBACKGROUNDPreventing post‐harvest waste of Palmyra palm (Borassus aethiopum Mart.) fruits is possible by recovery of pectin as a value‐added ingredient. Extraction conditions on yield and functionality of Palmyra palm pectin was determined at different temperatures and pH values with 30 min extraction time.RESULTSPalmyra palm fruits contain more than 650 g kg−1 galacturonic acid and produce soft gels with sucrose in acidic media despite a high degree of acetylation (∼5%). Mechanical deformation of pectin gel was similar when extracted at pH 2.5 and 70 °C or under natural pH at room temperature or 70 °C. Pectins isolated at pH 7 exhibited comparable gel softness (G′/G″) with commercial pectin. Palm pectins also showed emulsifying activity greater than 50%, attributed to high protein content of 8 g 100 g−1. For pectins extracted at pH near 5.2–5.5, molar mass ranged from 3.00 to 3.38 × 105 g mol−1; intrinsic viscosity ranged from 218 to 297 mL g−1; arabinose was the main neutral sugar; ζ‐potential ranged from −23 to −25 mV.CONCLUSIONPalm fruit offers an inexpensive raw material to extract pectin in environmentally friendly and economical way and yield a pectin with unique gelling, viscosifying and emulsifying properties. © 2016 Society of Chemical Industry
Egg white powder‐stabilised multiple (water‐in‐olive oil‐in‐water) emulsions as beef fat replacers in model system meat emulsions
Authors: Öztürk Burcu , Urgu Müge , Serdaroğlu Meltem 
Published: August 2016

AbstractBACKGROUNDToday, multiple emulsions are believed to have a considerable application potential in food industry. We aimed to investigate physical, chemical and textural quality characteristics of model system meat emulsions (MSME) in which beef fat (C) was totally replaced by 10% (E‐10), 20% (E‐20) or 30% (E‐30) multiple emulsions (W1/O/W2) prepared with olive oil and egg white powder (EWP).RESULTSIncorporation of W1/O/W2 emulsion resulted in reduced fat (from 11.54% to 4.01%), increased protein content (from 13.66% to 14.74%), and modified fatty acid composition, significantly increasing mono‐ and polyunsaturated fatty acid content and decreasing saturated fatty acid content. E‐20 and E‐30 samples had lower jelly and fat separation (5.77% and 5.25%) compared to C and E‐10 (9.67% and 8.55%). W1/O/W2 emulsion treatments had higher water‐holding capacity (93.96–94.35%) than C samples (91.84%), and also showed the desired storage stability over time. Emulsion stability results showed that E‐20 and E‐30 samples had lower total expressible fluid (14.05% and 14.53%) and lower total expressible fat (5.06% and 5.33%) compared to C samples (19.13% and 6.09%). Increased concentrations of W1/O/W2 emulsions led to alterations in colour and texture parameters. TBA values of samples were lower in W1/O/W2 emulsion treatments than control treatment during 60 days of storage.CONCLUSIONSOur results indicated that multiple emulsions prepared with olive oil and EWP had promising impacts on reducing fat, modifying the lipid composition and developing both technologically and oxidatively stable meat systems. These are the first findings concerning beef matrix fat replacement with multiple emulsions stabilised by EWP. © 2016 Society of Chemical Industry
Molecular DNA‐based detection of ionising radiation in meat
Authors: Şakalar Ergün 
Published: August 2016

AbstractBACKGROUNDIonising radiation induces molecular alterations, such as formation of ions, free radicals, and new stable molecules, and cleavage of the chemical bonds of the molecules present in food. Irradiation‐treated meat should be labelled to control the process and to ensure free consumer choice. Therefore, sensitive analytical methods are required to detect the irradiation dose.RESULTSMeat samples were exposed to radiation doses of 0, 0.272, 0.497, 1.063, 3.64, 8.82 and 17.42 kGy in an industrial 60Co gamma cell. Primers were designed to amplify 998, 498 and 250‐base pair (bp) regions of the 18S rRNA gene of nuclear DNA from the irradiated samples. A new DNA‐based method was developed to quantify the radiation exposed to the unstored meat and the meat stored at −20 °C for 3 and 6 months. The method was able to detect meat samples stored and unstored with dose limits of 1.063 and 3.64 kGy, respectively.CONCLUSIONThe level of irradiation can be detected using primer pairs that target particularly different‐sized sequences for DNA amplification by PCR. This method can be widely used for the analysis of not only meat samples, but also all biological materials containing DNA. © 2016 Society of Chemical Industry
Thermally Stable Dibenzo[def,mno]chrysene‐Based Polymer Solar Cells: Effect of Thermal Annealing on the Morphology and Photovoltaic Performances
Authors: Hong Jisu , Kim Yu Jin , Kim Yun‐Hi , Park Chan Eon 
Published: August 2016

The photovoltaic performances of dibenzo[def,mno]chrysene‐based polymer (poly(2,2′‐thiophenevinylenthiophene‐4,10‐[6,12‐bis(2‐decyltetradecyloxy)‐dibenzo[def,mno]chrysene]) (PTVTC) or poly(4,10‐bithiophene‐6,12‐bis(2‐decyltetradecyloxy)‐dibenzo[def,mno]chrysene) (PTTC)) solar cells as a function of thermal annealing temperatures from 100 to 180 °C are reported. Interestingly, the solar cells with PTTC containing two thiophene units, have superior thermal stability compared to the PTVTC:[6,6]‐phenyl‐C71‐butyric acid methyl ester (PC71BM) solar cells, in which the PTVTC has two thiophene and vinyl groups. Atomic force microscopy, transmission electron microscopy, and X‐ray diffraction demonstrate that morphological stability of PTTC:PC71BM blend films conduces thermally stable photovoltaic performances of PTTC solar cells. Therefore, the PTTC:PC71BM bulk heterojunction solar cells have highly stable efficiency, retaining 97% of its original power conversion efficiency value without PCBM clusters in the blend films even at elevated temperatures. There have been no previous reports on the thermal stability aspect of dibenzo[def,mno]chrysene‐based polymer solar cells so far.
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Cold Plasma Reticulation of Shape Memory Embolic Tissue Scaffolds
Authors: Nash Landon D. , Docherty Nicole C. , Monroe Mary Beth B. , Ezell Kendal P. , Carrow James K. , Hasan Sayyeda M. , Gaharwar Akhilesh K. , Maitland Duncan J. 
Published: August 2016

Polyurethane shape memory polymer (SMP) foams are proposed for use as thrombogenic scaffolds to improve the treatment of vascular defects, such as cerebral aneurysms. However, gas blown SMP foams inherently have membranes between pores, which can limit their performance as embolic tissue scaffolds. Reticulation, or the removal of membranes between adjacent foam pores, is advantageous for improving device performance by increasing blood permeability and cellular infiltration. This work characterizes the effects of cold gas plasma reticulation processes on bulk polyurethane SMP films and foams. Plasma‐induced changes on material properties are characterized using scanning electron microscopy, uniaxial tensile testing, goniometry, and free strain recovery experiments. Device specific performance is characterized in terms of permeability, platelet attachment, and cell–material interactions. Overall, plasma reticulated SMP scaffolds show promise as embolic tissue scaffolds due to increased bulk permeability, retained thrombogenicity, and favorable cell–material interactions.
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The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
Authors: Stevaert Annelies , Naesens Lieve 
Published: August 2016

AbstractInfluenza viruses cause seasonal epidemics and pandemic outbreaks associated with significant morbidity and mortality, and a huge cost. Since resistance to the existing anti‐influenza drugs is rising, innovative inhibitors with a different mode of action are urgently needed. The influenza polymerase complex is widely recognized as a key drug target, given its critical role in virus replication and high degree of conservation among influenza A (of human or zoonotic origin) and B viruses. We here review the major progress that has been made in recent years in unravelling the structure and functions of this protein complex, enabling structure‐aided drug design toward the core regions of the PA endonuclease, PB1 polymerase, or cap‐binding PB2 subunit. Alternatively, inhibitors may target a protein–protein interaction site, a cellular factor involved in viral RNA synthesis, the viral RNA itself, or the nucleoprotein component of the viral ribonucleoprotein. The latest advances made for these diverse pharmacological targets have yielded agents in advanced (i.e., favipiravir and VX‐787) or early clinical testing, besides several experimental inhibitors in various stages of development, which are all covered here.
Plasma trimethylamine‐N‐oxide following supplementation with vitamin D or D plus B vitamins
Authors: Obeid Rima , Awwad Hussain M. , Kirsch Susanne H. , Waldura Christiane , Herrmann Wolfgang , Graeber Stefan , Geisel Juergen 
Published: August 2016

ScopeWe compared the effect of supplementation with vitamin D + B or vitamin D on plasma trimethylamine N‐oxide (TMAO) and choline metabolites.Methods and resultsThis is a randomized single‐blinded nonplacebo‐controlled study. Twenty‐seven participants received 1200 IU vitamin D3 and 800 mg calcium, and 25 participants received additionally 0.5 mg folic acid, 50 mg B6, and 0.5 mg B12 for 1 year. Plasma homocysteine (Hcy), TMAO, and choline metabolites were measured at baseline and 12 months later. TMAO declined in the vitamin D arm by 0.5 versus 2.8 μmol/L in the D + B arm (p = 0.005). Hcy decreased and betaine increased in the D + B compared to the D arm. Within‐subject levels of plasma choline and dimethylglycine and urine betaine increased in both arms and changes did not differ between the arms. TMAO reduction was predicted by higher baseline TMAO and lowering Hcy in stepwise regression analysis. The test–retest variations of TMAO were greater in the D + B arm compared to vitamin D arm.ConclusionB vitamins plus vitamin D lowered plasma fasting TMAO compared to vitamin D. Vitamin D caused alterations in choline metabolism, which may reflect the metabolic flexibility of C1‐metabolism. The molecular mechanisms and health implications of these changes are currently unknown.
Frequency tracking optical beamforming system using uncooled Fabry‐Perot lasers
Authors: Ren Jianqiao , Pulikkaseril Cibby , Yi Xiaoke 
Published: August 2016

ABSTRACTWe present a novel optical beamforming network that is able to use an uncooled Fabry‐Perot (FP) laser as the optical source. This is achieved by tracking the frequency and power drift of an FP laser and compensating these changes with programmable amplitude and phase in a liquid crystal‐on‐silicon Fourier domain optical processor. The system realizes six microwave phase shifters that operate simultaneously over 12–39.5 GHz with amplitude and phase response variation of 6.1 dB and 14.8°, respectively, under the conditions of changing laser current. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2537–2540, 2016
New compact planar wideband antenna with flat gain and good pattern stability
Authors: Noraei Yeganeh Ali , Hesamoddin Najmolhoda Sayed , Hassan Sedighy Seyed , Mohammad‐Ali‐Nezhad Sajad 
Published: August 2016

ABSTRACTA new planar compact wideband dipole antenna with new feed structure is presented. The wideband operation of the proposed antenna is interpreted and a closed form formula for its design process is extracted. Then, three cases of the proposed antenna is designed and simulated to verify the extracted formula. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2548–2554, 2016
New shield structure for retrodirective and invisible applications
Authors: Caravantes Jorge , Mediavilla Paula , Tazón Antonio , Fernández Tomás , Vassal'lo Juan 
Published: August 2016

ABSTRACTRetrodirectivity and invisibility are two opposite concepts in the radar context. The former looks for an evident identification, while the latter aims to remain unnoticed. Here, we present a new structure based on inverted conical surfaces to provide both effects depending on the conical aperture value: 90° for retrodirective applications and 120° for invisible and Wi‐Fi/Li‐Fi applications.Results of the study carried out to confirm the behavior of the two structures are also presented, including measurements to compare performance with commercial prototypes in the case of retrodirectivity. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2570–2577, 2016
Large‐scale transient electrical‐thermal co‐simulation of interconnects under electromagnetic pulses
Authors: Lu Tianjian , Jin Jian‐Ming 
Published: August 2016

ABSTRACTThe electrical‐thermal co‐simulation is employed to analyze the transient electrical and thermal behaviors of large‐scale on‐chip and 3‐D interconnects. The analyses are performed when the interconnects are exposed to electromagnetic pulses in order to simulate both self‐heating effects under normal working conditions and thermal breakdowns under electrostatic discharge stresses. The impact of power maps on the transient thermal responses under the electrostatic discharge stress is also studied. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2559–2563, 2016
Experimental realization of micromachined terahertz corrugated conical horn antenna
Authors: Zhao Pengfei , Lv Xin , Lu Hongda , Liu Yong 
Published: August 2016

ABSTRACTA terahertz (THz) corrugated conical horn antenna with ring‐loaded slots based on silicon micromachining technology is proposed. The radiation patterns are designed to be asymmetrical in both the E‐ and H‐plane with sidelobe below −30 dB in the E‐plane at 500 GHz. Good agreements between the simulated and measured results are observed. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2563–2566, 2016
A novel compact dual‐band dual‐polarized microstrip patch antenna for GSM/DCS applications
Authors: Vedaee Ali , Hassani Hamid R. 
Published: August 2016

ABSTRACTIn this paper, a novel compact dual‐band dual‐polarized microstrip stacked patch antenna suitable for base stations is presented. The first and second frequency bands cover the GSM and DCS bands respectively. The antenna layout consists of a single circular patch with four symmetrical slots along its periphery mainly responsible for the upper frequency band and one cross‐shaped slot at the center, mainly responsible for the lower one. The stacked configuration is considered for bandwidth enhancement. The antenna utilizes a simple orthogonal feed network for the two polarizations, which feeds the patch through a relatively wide cross‐shaped slot at the antenna's ground plane, placed centrally with respect to the patch. The antenna bandwidth completely covers the two desired bands with relatively good return loss and also exhibits polarization isolation of greater than 33 dB and 40 dB in the lower and upper frequency bands respectively. In addition, the antenna has good radiation characteristics in terms of cross‐polarization in both bands of interest. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2557–2559, 2016
An l‐shaped 4‐element monopole MIMO antenna system with enhanced isolation for mobile applications
Authors: Ikram M. , Hussain R. , Hammi O. , Sharawi M. S. 
Published: August 2016

ABSTRACTIn this work, a 4‐element wideband printed modified monopole based multiple‐input multiple‐output (MIMO) antenna system is presented. The proposed design is compact, low profile, and suitable to be used for wireless handheld devices in 3G and 4G LTE bands. The covered measured frequencies lie between 2017 and 2265 MHz. The proposed design is evaluated for MIMO performance metrics. A defected ground structure that is based on a combination of an array of vertical slots and one circular slot is used to enhance the isolation. The envelope correlation coefficient was <0.1889. The MIMO antenna system is built on a double layer FR‐4 substrate with height of 0.8mm and dielectric constant of 4.4. The total size of the design is 100 × 60 × 0.8 mm3. Good agreement between simulated and measured results is obtained. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2587–2591, 2016
A comparative study of different gain cells based microwave CMOS distributed oscillators
Authors: Bhattacharyya Kalyan , Sharma D. K. 
Published: August 2016

ABSTRACTDifferent gain cells used for Distributed oscillators (DOs) have been studied through extensive simulations. Measured results for a cascode DO are also reported, with oscillation frequency of around 10.1 GHz with 4.63 dBm output power at 1.8 V and phase noise of −114 dBc/Hz at 1 MHz offset from the carrier. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2581–2587, 2016
Fiber extended ultra‐wideband radar for breath tracking through 10 cm concrete
Authors: Frejstrup L. , Monroy I. Tafur , Olmos J. J. Vegas 
Published: August 2016

ABSTRACTThis article presents an Ultra‐Wideband (UWB) radar with a 20 km NZ‐DSF extension on the transmitter side. The radar is based on telecom class signal generation, antennas, and a recording module operating at 20 Gsa/s. The radar is transmitting a pulse covering the frequencies from 3.4 to 9.9 GHz. The radar system was able to track the breathing of a human through a 10 cm concrete obstacle. The frequency output was verified through the use of a metal pendulum with a fixed oscillation period. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2612–2614, 2016
Multi‐probe remote differential optical low‐coherence reflectometer
Authors: Ferreira da Silva Thiago 
Published: August 2016

ABSTRACTI propose and evaluate a multi‐probe optical low‐coherence reflectometer that simultaneously measures, with sub‐micron resolution, relative axial distances sampled on a reflexive surface. The technique is assessed as suitable for in‐field high‐resolution remote contactless evaluation of surfaces by simultaneously measuring four points in a target 22‐km apart from the reflectometer. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2606–2609, 2016
Design of a dual‐band patch antenna with circular parasitic elements for adaptive polarization adjustment
Authors: Yoo S. J. , Choo H. , Byun G. 
Published: August 2016

ABSTRACTThis letter proposes the design of microstrip patch antennas for independent polarization adjustments in two frequency bands. The proposed antenna consists of two radiating patches for dual‐band operation, and each patch is composed of a circular resonator and surrounding parasitic elements. The antenna polarization is adaptively adjusted by rotating these parasitic elements for each patch without changing other design parameters. As an evaluation, two sample antennas with linear and circular polarizations are fabricated to measure their radiation characteristics. The results prove that the proposed structure is capable of independent polarization adjustments for dual‐band operations. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2643–2649, 2016
Base‐band training of carrier leakage canceller in 5.8‐GHz full‐duplex transceivers
Authors: Maddio Stefano , Cidronali Alessandro , Collodi Giovanni 
Published: August 2016

ABSTRACTThis article introduces a training technique suitable for an active analog carrier leakage canceller, based on base‐band signal processing. The proposed training approach leads to the optimum canceller parameters by observing at base‐band the magnitude of a pilot signal amplitude‐modulating the carrier, which is generated by the base‐band processor in the transmitter and received due the leakage through the receiver chain.An experimental characterization applied to a road‐side unit operating in full‐duplex mode for an electronic toll collection system, under regulation ETSI ES200674, demonstrates that the leakage mitigation reaches up to 35 dB with the leakage between transmitter and receiver maintained below −60 dB, and resulting in a signal‐noise ratio enhancement of 30 dB © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2649–2653, 2016