bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relapsed mantle cell lymphoma manifesting with soft tissue tumors of the extremities: University of Miami experience and review of the literature
Authors: Trutzer Iris Margalit , Lossos Izidore S. 
Published: September 2024

AbstractMantle cell lymphoma (MCL) is frequently diagnosed at advanced stages and is characterized by multiple extranodal sites of disease, most notably the bone marrow, peripheral blood, and gastrointestinal tract. Historically the prognosis of mantle cell lymphoma has been poor with median survival of four to five years. With new treatment regimens, however, patients have been able to achieve prolonged remissions and require special attention while being evaluated for relapse. This report describes four patients treated for stage IV mantle cell lymphoma at the University of Miami who developed soft tissue relapse presenting as non-tender large masses of the extremities, including one patient who presented without associated nodal involvement. Average time to soft tissue relapse was 99 months (range: 28–240) following initial diagnosis. Providers who care for patients with mantle cell lymphoma should be aware of soft tissue lesions as a presentation of mantle cell lymphoma that merits evaluation for disease relapse.
Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice
Authors: Stone Thomas J. , Merve Ashirwad , Valerio Fernanda , Yasin Shireena A. , Jacques Thomas S. 
Published: September 2024

AbstractLow-grade gliomas are a cause of severe and often life-long disability in children. Pathology plays a key role in their management by establishing the diagnosis, excluding malignant alternatives, predicting outcomes and identifying targetable genetic alterations. Molecular diagnosis has reshaped the terrain of pathology, raising the question of what part traditional histology plays. In this review, we consider the classification and pathological diagnosis of low-grade gliomas and glioneuronal tumours in children by traditional histopathology enhanced by the opportunities afforded by access to comprehensive genetic and epigenetic characterisation.
State of the art medical devices for fluorescence-guided surgery (FGS): technical review and future developments
Authors: Preziosi Alessandra , Cirelli Cecilia , Waterhouse Dale , Privitera Laura , De Coppi Paolo , Giuliani Stefano 
Published: September 2024

Abstract
Background
Medical devices for fluorescence-guided surgery (FGS) are becoming available at a fast pace. The main challenge for surgeons lies in the lack of in-depth knowledge of optical imaging, different technical specifications and poor standardisation, and the selection of the best device based on clinical application.

Methods
This manuscript aims to provide an up-to-date description of the commercially available fluorescence imaging platforms by comparing their mode of use, required settings, image types, compatible fluorophores, regulatory approval, and cost. We obtained this information by performing a broad literature search on PubMed and by contacting medical companies directly. The data for this review were collected up to November 2023.

Results
Thirty-two devices made by 19 medical companies were identified. Ten systems are surgical microscopes, 5 can be used for both open and minimally invasive surgery (MIS), 6 can only be used for open surgery, and 10 only for MIS. One is a fluorescence system available for the Da Vinci robot. Nineteen devices can provide an overlay between fluorescence and white light image. All devices are compatible with Indocyanine Green, the most common fluorescence dye used intraoperatively. There is significant variability in the hardware and software of each device, which resulted in different sensitivity, fluorescence intensity, and image quality. All devices are CE-mark regulated, and 30 were FDA-approved.

Conclusion
There is a prolific market of devices for FGS and healthcare professionals should have basic knowledge of their technical specifications to use it at best for each clinical indication. Standardisation across devices must be a priority in the field of FGS, and it will enhance external validity for future clinical trials in the field.

Graphical abstract
Impact of COVID-19 in the web accessibility of higher education institutions: a pending challenge
Authors: Nso-Mangue P. , Cachero-Castro C. , Meliá S. , Luján-Mora S. 
Published: September 2024

AbstractThe COVID-19 pandemic forced educational institutions to close and led to a radical transformation of the global education system. This process of change had to take place in a short period of time and, as a result, methodologies and learning tools were adapted. The closure of educational institutions and the disruption to learning impacted all students. However, vulnerable students, including those with disabilities, were particularly affected due to the lack of preparedness for inclusive learning during the rapid transition to emergency online learning. One of the many challenges faced by educational institutions during this transition was ensuring web accessibility for students with disabilities. However, it appears that some of the positive changes that took place in the education system during the pandemic, such as the enhancement of web accessibility, have been declining recently. The aim of this article is to review how a group of universities responded to the closure caused by the pandemic from the point of view of web accessibility, whether they improved the accessibility of their websites and whether this improvement has been maintained over time. To achieve this, the web accessibility of the home pages of selected universities around the world was evaluated against Web Content Accessibility Guidelines 2.1, for the period from 2018 to 2024. The results show that there was an improvement in web accessibility immediately after the COVID-19 outbreak, but this trend has not been maintained.
Levees for a hundred-year flood: impact of a syndrome-based antimicrobial stewardship intervention for coronavirus disease 2019 on antimicrobial use and resistance
Authors: Mena Lora Alfredo J. , Burgos Rodrigo , Huber Dylan , Sanchez Lawrence , Ali Mirza , Krill Candice , Takhsh Eden , Bleasdale Susan C. 
Published: September 2024

Abstract
Coronavirus disease 2019 can be indistinguishable from lower respiratory tract infections (LRTIs) caused by other viral and bacterial agents. This likely contributed to antimicrobial use (AU) and antimicrobial resistance (AMR) during the pandemic. Our antimicrobial stewardship program targeted the selection and duration of therapy for LRTIs and led to a reduction in AU and AMR.
Staphylococcus aureus infection disparities among Hispanics and non-Hispanics in Yuma, Arizona
Authors: Pearson Talima , Kramer Sarah , Panisello Yagüe David , Nangkuu Emmanuel , Medina-Rodriguez Sarah , Wood Colin , Hepp Crystal , Camplain Ricky , Mihaljevic Joseph , Milner Trudie 
Published: September 2024

Abstract
Staphylococcus aureus infection patterns in Yuma, Arizona show a 2.25x higher infection rate in non-Hispanics. Males had higher infection rates in most age classes. These disparities in infection are mostly consistent with previously observed patterns in colonization, suggesting that sex and ethnicity do not differentially impact colonization and infection.
High catalytic performance of thermally treated Mn-rich limonite for catalytic oxidation of toluene
Authors: Dong Shiwei , Chen Tianhu , Zhang Yinsheng , Liu Haibo , Ji Minghao , Zhu Chengzhu , Zou Xuehua 
Published: September 2024

Abstract
The development of active and low-cost transition metal oxide-based catalysts was vital for the catalytic oxidation of toluene. This study aimed to prepare Fe-Mn oxide catalysts by Mn-rich limonite, and investigate the catalytic activity and mechanism for toluene oxidation. The natural Mn-rich limonite was thermally activated at different temperatures and these thermally activated samples exhibited different oxidation activities. YL-300, obtained through thermal treatment at 300°C, exhibited excellent catalytic activity, showing 90% toluene conversion at 239°C (1000 ppm toluene) and remarkable catalytic stability even in the presence of water vapor (5 vol.%). The amount of oxygen vacancies in the catalyst was regulated by tuning the thermal treatment temperatures. Optimal thermal treatment facilitated the increase of oxygen vacancies and enhanced the oxygen mobility and redox capacity of YL-300, contributing to the complete oxidation of toluene to H2O and CO2. The oxidation of toluene was greatly influenced by the adsorbed oxygen species. This study demonstrates the potential of Mn-rich limonite as a promising catalyst for toluene oxidation, thereby promoting the utilization of natural mineral materials in the field of environmental pollution control.
Psychological Impact of Disaster Relief Operations: A Study Following Consecutive Earthquakes in Turkey
Authors: Iseri Ali , Baltaci Recep 
Published: September 2024

Abstract

Objective
This cross-sectional study investigates the immediate psychological effects of disaster relief operations on team members following 2 consecutive major earthquakes in Turkey.

Methods
A total of 170 participants, including professional firefighters, search and rescue (SAR) workers, and volunteers, were surveyed approximately 1 month after the conclusion of active SAR operations. The study utilizes the DSM-V criteria and the Posttraumatic Stress Disorder Checklist (PCL-5) to assess symptoms of post-traumatic stress disorder (PTSD) among participants.

Results
The findings reveal a point prevalence of 35.3% for probable PTSD, highlighting the substantial psychological impact on disaster relief teams. Factors such as age, residency in affected areas, and active SAR involvement significantly influenced probable PTSD rates. Interestingly, actively engaged SAR members had lower probable PTSD rates, possibly due to their training. Those who directly witnessed the earthquakes had higher scores, highlighting the impact of firsthand exposure. Additionally, individuals aged 50 and above displayed a higher mean total severity score compared to younger participants.

Conclusions
This research contributes to understanding the mental well-being of disaster relief professionals. The study’s findings underscore the importance of timely mental health support and training for these responders, emphasizing the need for preparedness in disaster relief teams.
Challenges in applying large language models to requirements engineering tasks
Authors: Norheim Johannes J. , Rebentisch Eric , Xiao Dekai , Draeger Lorenz , Kerbrat Alain , de Weck Olivier L. 
Published: September 2024

Abstract
Growth in the complexity of advanced systems is mirrored by a growth in the number of engineering requirements and related upstream and downstream tasks. These requirements are typically expressed in natural language and require human expertise to manage. Natural language processing (NLP) technology has long been seen as promising to increase requirements engineering (RE) productivity but has yet to demonstrate substantive benefits. The recent addition of large language models (LLMs) to the NLP toolbox is now generating renewed enthusiasm in the hope that it will overcome past shortcomings. This article scrutinizes this claim by reviewing the application of LLMs for engineering requirements tasks. We survey the success of applying LLMs and the scale to which they have been used. We also identify groups of challenges shared across different engineering requirement tasks. These challenges show how this technology has been applied to RE tasks that need reassessment. We finalize by drawing a parallel to other engineering fields with similar challenges and how they have been overcome in the past – and suggest these as future directions to be investigated.
Dangerous Legacy of Food Contact Materials on the EU Market: Recall of Products Containing PFAS
Authors: Ribes Ortega Carme , Molitorisová Alexandra , Purnhagen Kai 
Published: September 2024

Abstract
Toxic substances and endocrine disruptors are present in consumer goods on the European Union (EU) market, such as in food contact materials like cookware. This article investigates whether a legal recall obligation of such products exists in EU law, and in the absence of such an obligation, how the EU legislature has ensured that such products are disposed of in a manner that does not compromise human health and the environment when they become waste. For this purpose, this Article analyses recall obligations for food contact materials containing persistent organic pollutants, as well as their waste regulations. It focuses on a class of substances with non-stick properties, some of them formerly used in cookware, such as pentadecafluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). We show that there is no single legal recall obligation; rather, many legal obligations are scattered among different provisions of EU law. When read together, they form a complex web of obligations, which may lead to recall measures for most of these products. However, doubts over the feasibility and effectiveness of such recalls remain.
The Role of Heuristics and Biases in the Choice of Risk Triggers for Novel Foods and GMOs in the European Union
Authors: Monaco Alessandro 
Published: September 2024

Abstract
In the European Union (EU), novel foods and Genetically Modified Organisms (GMOs) are subject to long and costly authorisation procedures and post-marketing requirements. The regulatory frameworks applicable to novel foods and GMOs come into effect based on perceived factors of risk. These “risk triggers” are characteristics of novel foods and GMOs which differentiate them from traditional foods, creating a presumption of risk. Within the EU, consumer acceptance of genetically modified foods and novel foods like insects or cultivated meat is shaped by heuristics and biases, mainly focusing on the “novelty” and “unnaturalness” of these products, resulting in a predominantly negative perception. This paper investigates the close connection between cognitive biases identified in consumer perception literature and the implementation of specific risk triggers in the regulation of novel foods and GMOs in the EU. It subsequently raises concerns about the appropriateness of these risk triggers in forming a presumption of risk for these innovative products.
Coffee intake leads to preeclampsia-like syndromes in susceptible pregnant rats
Authors: Chen Linyan , Duan Yi , Wang Pan 
Published: September 2024

Abstract
Coffee is one of the most popular beverages worldwide, and there is an increasing concern of the health risk of coffee consumption in pregnancy. Preeclampsia (PE) is a serious pregnancy disease that causes elevated blood pressure and proteinuria in pregnant women and growth restriction of fetuses due to poorly developed placental vasculature. The aim of our study is to investigate the possible effect of coffee intake during pregnancy in rats with potential underlying vasculature conditions. The endothelial nitric oxide synthase inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME) at a high dose (125 mg/kg/d) was used to induce PE in pregnant rats, which were used as the positive control group. In addition, low-dose L-NAME (10 mg/kg/d) was used to simulate the compromised placental vasculature function in pregnant rats. Coffee was given together with low-dose L-NAME to the pregnant rats from gestational day 10.5–18.5. Our results show that the pregnant rats treated with low-dose L-NAME + coffee, but not low-dose L-NAME alone, developed PE symptoms such as prominent fetal growth restriction, hypertension, and proteinuria. Therefore, our findings suggest that coffee intake during pregnancy may cause an increased risk of PE in susceptible women.
A systematic review of the implementation of healthy food retail interventions in settings with multiple food retail outlets (complex food retail settings)
Authors: Gupta Adyya , Huggins Catherine E. , Sacks Gary , Gittelsohn Joel , Peeters Anna 
Published: September 2024

Abstract
Complex food retail settings, where multiple food retail outlets operate in close proximity are common. Despite their ubiquity, there remains a significant knowledge gap regarding healthy food retail interventions implemented within these settings. Furthermore, understanding the factors affecting the implementation of interventions in these settings remains limited. This systematic review aimed to (1) identify and describe complex food retail settings where interventions were implemented to promote the healthiness of foods purchased, (2) synthesise the evidence on the effectiveness of the interventions implemented, and (3) identify enablers and barriers to the implementation of the interventions in these settings. Four databases, namely, MEDLINE Complete, Global Health, Embase, and Business Source Complete, were searched until December 2022. The Effective Public Health Practice Project quality assessment tool was used. Six studies reported on the implementation of interventions promoting healthy food purchases across multiple food retail outlets. Three studies each described two complex food retail settings: university and hospital. Interventions including promotion and promotion plus price improved the healthiness of foods purchased. There was limited description of institutional food policies, conceptual frameworks, formative research, or evaluation outcomes to inform the implementation of interventions in these settings. No study analysed enablers and barriers to the implementation of interventions. No study identified their settings as complex food retail settings. There is limited evidence describing complex food retail settings, their impact on intervention effectiveness, and associated enablers or barriers. Investigating factors influencing the effectiveness of interventions implemented within complex food retail settings is critical to support their implementation at scale.
3D relativistic MHD simulations of the gamma-ray binaries
Authors: Barkov Maxim , Kalinin Evgeniy , Lyutikov Maxim 
Published: September 2024

Abstract
In gamma-ray binaries neutron star is orbiting a companion that produces a strong stellar wind. We demonstrate that observed properties of ‘stellar wind’–‘pulsar wind’ interaction depend both on the overall wind thrust ratio, as well as more subtle geometrical factors: the relative direction of the pulsar’s spin, the plane of the orbit, the direction of motion, and the instantaneous line of sight. Using fully 3D relativistic magnetohydrodynamical simulations we find that the resulting intrinsic morphologies can be significantly orbital phase-dependent: a given system may change from tailward-open to tailward-closed shapes. As a result, the region of unshocked pulsar wind can change by an order of magnitude over a quarter of the orbit. We calculate radiation maps and synthetic light curves for synchrotron (X-ray) and inverse-Compton emission (GeV-TeV), taking into account

$\gamma $

–

$\gamma $

absorption. Our modelled light curves are in agreement with the phase-dependent observed light curves of LS5039.
Imaging pulsar census of the galactic plane using MWA VCS data
Authors: Sett S. , Sokolowski M. , Lenc E. , Bhat N.D.R. 
Published: September 2024

Abstract
Traditional pulsar surveys have primarily employed time-domain periodicity searches. However, these methods are susceptible to effects like scattering, eclipses, and orbital motion. At lower radio frequencies (

$\lesssim$

300 MHz), factors such as dispersion measure and pulse broadening become more prominent, reducing the detection sensitivity. On the other hand, image domain searches for pulsars are not limited by these effects and can extend the parameter space to regions inaccessible to traditional search techniques. Therefore, we have developed a pipeline to form 1-second full Stokes images from offline correlated high time-resolution data from the Murchison Widefield Array (MWA). This led to the development of image-based methodologies to identify new pulsar candidates. In this paper, we applied these methodologies to perform a low-frequency image-based pulsar census of the galactic plane (12 MWA observations, covering

$\sim$

6 000

$\textrm{deg}^\textrm{2}$

sky). This work focuses on the detection of the known pulsar population which were present in the observed region of the sky using both image-based and beamformed methods. This resulted in the detection of 83 known pulsars, with 16 pulsars found only in Stokes I images but not in periodicity searches applied in beamformed data. Notably, for 14 pulsars these are the first reported low-frequency detections. This underscores the importance of image-based searches for pulsars that may be undetectable in time-series data, due to scattering and/or dispersive smearing at low frequencies. This highlights the importance of low-frequency flux density measurements in refining pulsar spectral models and investigating the spectral turnover of pulsars at low frequencies.
Modelling chronologically ordered radiocarbon dates in R
Authors: Blaauw Maarten , Aquino-López Marco , Christen J. Andrés 
Published: September 2024

Abstract
Studies with multiple radiocarbon dates often contain useful information on the relative locations of the dated levels. Such information can be used to obtain robust, integrated site chronologies, with at times more precise ages than those of the individual dates, where outliers can be identified and downweighted, and where the ages of any undated levels can also be estimated. Examples include trees with radiocarbon dates separated by exactly known amounts of yearly tree-rings, or sedimentary sites where ages further down the stratigraphy can be assumed to be older than ages further up. Here we present coffee, an R package for Bayesian models that apply chronological ordering for fossils and environmental events. Coffee runs natively within the popular and versatile R environment, with no need for importing or exporting data or code from other programs, and works with plain-text input files that are relatively easy to read and write. It thus provides a new, transparent and adaptable educational and research platform designed to make chronology building more accessible.
Radiocarbon dating of illegal ivory confirmed by Milos Forman’s Hair
Authors: Kufnerová Jitka , Heroldová Helena , Kukla Jaroslav , Křivohlavý Filip , Světlík Ivo , Pachnerová Brabcová Kateřina 
Published: September 2024

Abstract
Illegal poaching brought elephant species to the brink of extinction; therefore, international trade in ivory has become regulated by the Convention on International Trade in Endangered Species of Flora and Fauna (CITES). However, the trade is still allowed for antique items, standing for ivory from a period before 1947 within the European Union. This could serve as a loophole for the laundering of modern ivory. In the described case of the Happy Fisherman statuette, the traded item was declared to be antique, but radiocarbon analysis proved a modern provenance, and the statuette was confiscated. The radiocarbon analysis was later confirmed by information from a Chinese newspaper found inside the statuette. Based on the findings, we strongly recommend careful consideration of each individual ivory piece offered for sale, with a thorough inspection of the items and related documentation carried out by a relevant CITES authority. Any exemption of the commercial ban should be granted only to those applicants who meet the criteria of proper evidence in the form of scientific analysis or reliable and trustworthy documentation.