bluuebunny/crossref_metadata_2025_split huggingface dataset:
New records of Sylvicola (Diptera: Anisopodidae) from Romania
Authors: Kolcsár Levente-Péter , Dvořák Libor , Beuk Paul 
Published: February 2016

Anisopodidae (window gnats or wood gnats) is a small family of nematocerous Diptera. Until now only Sylvicola (Anisopus) punctatus (Fabricius, 1787) and Sylvicola (Sylvicola) fenestralis (Scopoli, 1763)​ were reported from Romania.
New faunistic records of Sylvicola (Diptera: Anisopodidae) are presented. Sylvicola (Sylvicola) cinctus (Fabricius, 1787) and S. (Anisopus) fuscatus (Fabricius, 1775) are recorded from Romania for the first time. An identification key and illustrations of Romanian Sylvicola species are presented.
Le caring, une voie pour reconfigurer l’École française au moment de sa refondation ?
Authors: Réto Gwénola 
Published: February 2016

À l’heure de la refondation de l’École française, cet article propose de confronter deux projets : celui porté par l’éthique du care et celui porté par l’Éducation Nationale afin d’envisager la possibilité de les faire entrer en dialogue. S’appuyant sur des textes du projet national, il interroge les liens entre le care et une notion en vogue dans le système éducatif français, celle de « bienveillance ». Puis, partant de l’hypothèse que cette bienveillance attendue a à voir avec le caring, il propose de prendre appui sur les travaux menés par la philosophe de l’éducation Nel Noddings afin de voir comment ces derniers peuvent contribuer à la configuration de la bienveillance tel qu’attendu pour le système français. Le fondement relationnel du caring et les quatre phases de son développement définies par Noddings permettent alors à la bienveillance de gagner en précision et en opérationnalisation et d’étayer le projet de refondation de l’école.
Pratiques de l’écrit et temporalités dans le travail domestique de jeunes mères
Authors: Mercier Jean-Pierre 
Published: February 2016

Le travail domestique peut être vu comme occupant une partie du care. Il est tramé par de nombreuses pratiques sociales de l’écrit. Une étude de cas ethnographique a permis de documenter un ensemble de pratiques de l’écrit orientées vers la réalisation de ce travail par des jeunes mères (n =31). Ces femmes articulent ces pratiques à des temporalités différentes : la temporalité du moment présent et celle du moment futur, soit au registre des évènements planifiés ou à celui de l’avenir anticipé. Le but de cet article est de présenter ces pratiques de l’écrit et ces temporalités. Les résultats aident à comprendre les réalités que vivent ces femmes de retour en formation dans Ma place au soleil, une mesure québécoise de soutien à la formation et à l’intégration sociale et professionnelle des jeunes parents non diplômés du secondaire. Les résultats aident aussi à comprendre comment ces femmes concilient le travail domestique et le travail scolaire.
Exercice et apprentissage du métier d’infirmier : à la recherche du Care
Authors: Eyland Isabelle , Jean Alain 
Published: February 2016

La notion du prendre soin a toujours été attachée à la fonction de l’infirmière mais le terme de care est devenu de plus en plus populaire dans divers domaines comme l’éducation, la sociologie ou la politique. Les premières mentions au concept datent des années 1970 aux USA et ont donné suite à de nombreux travaux, écrits et définitions… Dans le domaine des soins infirmiers, toute situation est l’occasion d’une rencontre sociale qui permet aux soignants échanges, engagement émotionnel et mise en pratique des activités liées au care. Pourtant, le concept est mis à mal… Et quelle place lui est-il donné en formation des étudiants en soins infirmiers ?
Devenir professeur des écoles aujourd’hui : motivations, représentations, perspectives
Authors: Pachod André 
Published: February 2016

Les Écoles supérieures du professorat et de l’éducation (Espe) organisent depuis 2013 des masters métiers de l’enseignement, de l’éducation et de la formation. L’étude de 289 dossiers de candidatures et de lettres de motivation d’entrée en Master 1 du 1er degré fournit diverses caractéristiques d’une population d’étudiants. Elle renseigne également une recherche sur les modes et les dispositions d’accès au métier : devenir professeur des écoles, oui, mais pourquoi ? Ce choix se situe dans un processus décisionnel inscrit dans des événements biographiques, en réponse à des représentations sur les missions de l’enseignant, son identité professionnelle, son statut social, ses compétences professionnelles, sa formation. Enfin, cette étude situe l’intervenant en formation de master dans une triple préoccupation éthique : reconnaître le candidat dans une identité sociale déjà construite, faire entrer le futur enseignant dans le métier réel, préparer au concours de recrutement.
Molecular classification and prognostication of 300 node-negative breast cancer cases: A tertiary care experience
Authors: Shemin K. M. Zuhara , Smitha N. V. , Jojo Annie , Vijaykumar D. K. 
Published: February 2016

Abstract
Background: The proportion of node-negative breast cancer patients has been increasing with improvement of diagnostic modalities and early detection. However, there is a 20-30% recurrence in node-negative breast cancers. Determining who should receive adjuvant therapy is challenging, as the majority are cured by surgery alone. Hence, it requires further stratification using additional prognostic and predictive factors. Subjects and Methods: Ours is a single institution retrospective study, on 300 node-negative breast cancer cases, who underwent primary surgery over a period of 7 years (2005-2011). We excluded all cases who took NACT. Prognostic factors of age, size, lymphovascular emboli, estrogen receptor (ER), progesterone receptor (PR), HER2neu Ki-67, grade and molecular classification were analyzed with respect to those with and without early events (recurrence, metastases or second malignancy, death) using-Pearson Chi-square method and logistic regression method for statistical analysis. Results: Majority belonged to the age group of 50-70 years. On univariate analysis, size >5 cm (P = 0.03) and ER negativity had significant association (P = 0.05) for early failures; PR negativity and lymphovascular emboli (LVE) had borderline significance (P = 0.07). Multivariate analysis showed size >5 cm to be significant (P = 0.04) and LVE positivity showed borderline significant association (P = 0.07) with early failures. About 62% belonged to luminal category followed by basal-like (25%) in molecular classification. Conclusions: ER negativity, PR negativity, LVE/lymphovascular invasion positivity and size >5 cm (T3 and T4) are associated with poor prognosis in node-negative breast cancers.
Recurrent Glioblastoma: Where we stand
Authors: Roy Sanjoy , Lahiri Debarshi , Maji Tapas , Biswas Jaydip 
Published: February 2016

AbstractCurrent first-line treatment regimens combine surgical resection and chemoradiation for Glioblastoma that provides a slight increase in overall survival. Age on its own should not be used as an exclusion criterion of glioblastoma multiforme (GBM) treatment, but performance should be factored heavily into the decision-making process for treatment planning. Despite aggressive initial treatment, most patients develop recurrent diseases which can be treated with re-resection, systemic treatment with targeted agents or cytotoxic chemotherapy, reirradiation, or radiosurgery. Research into novel therapies is investigating alternative temozolomide regimens, convection-enhanced delivery, immunotherapy, gene therapy, antiangiogenic agents, poly ADP ribose polymerase inhibitors, or cancer stem cell signaling pathways. Given the aggressive and resilient nature of GBM, continued efforts to better understand GBM pathophysiology are required to discover novel targets for future therapy.
A relationship between quality-of-life and head and neck cancer: A systemic review
Authors: Parkar Sujal Mitul , Shah Mihir N. 
Published: February 2016

Abstract
Aim: The aim was to identify the literature and to assess the association between quality-of-life (QoL) and head and neck cancer (HNC) related outcomes systemically. Materials and Methods: The full articles published in English language bio-medical journals between 1992 and December 2014 were searched using Medline database. The keywords used for searching the articles include the combination of "health-related of QoL," "QoL," "HNC." The search limited only to the observational studies using questionnaires European Organization for Research and Treatment of Cancer (EORTC) QLQ C 30 and EORTC QLQ H and N 35. Purely psychological studies were excluded. Results: A total of 5055 articles were retrieved, and 16 articles were selected for this review. Of 16 observational studies, 13 (81.25%) were prospective cohort studies while remaining 3 (18.75%) were cross-sectional studies. The main findings of the studies revealed that the treatment of HNC had a statistically significant influence on QoL. Others associated factors like age, female sex, duration of treatment, advance tumor, and site of the tumor has also the impact on QoL on patients suffering from HNC. Conclusion: This review provides evidence for a positive relationship between cancer-related outcomes and QoL. Assessment of QoL in relation to HNC with proper methodology and validated instruments is lacking hence there is a need for further evidence to support the relation between cancer and QoL.
On the long-term impact of emissions from central European cities on regional air quality
Authors: Huszar P. , Belda M. , Halenka T. 
Published: February 2016

Abstract. For the purpose of qualifying and quantifying the impact of urban emission from Central European cities on the present-day regional air quality, the regional climate model RegCM4.2 was coupled with the chemistry transport model CAMx, including two-way interactions. A series of simulations was carried out for the 2001–2010 period either with all urban emissions included (base case) or without considering urban emissions. Further, the sensitivity of ozone production to urban emissions was examined by performing reduction experiments with −20 % emission perturbation of NOx and/or non-methane volatile organic compounds (NMVOC). The modeling system's air quality related outputs were evaluated using AirBase, and EMEP surface measurements showed reasonable reproduction of the monthly variation for ozone (O3), but the annual cycle of nitrogen dioxide (NO2) and sulfur dioxide (SO2) is more biased. In terms of hourly correlations, values achieved for ozone and NO2 are 0.5–0.8 and 0.4–0.6, but SO2 is poorly or not correlated at all with measurements (r around 0.2–0.5). The modeled fine particulates (PM2.5) are usually underestimated, especially in winter, mainly due to underestimation of nitrates and carbonaceous aerosols. European air quality measures were chosen as metrics describing the cities emission impact on regional air pollution. Due to urban emissions, significant ozone titration occurs over cities while over rural areas remote from cities, ozone production is modeled, mainly in terms of number of exceedances and accumulated exceedances over the threshold of 40 ppbv. Urban NOx, SO2 and PM2.5 emissions also significantly contribute to concentrations in the cities themselves (up to 50–70 % for NOx and SO2, and up to 60 % for PM2.5), but the contribution is large over rural areas as well (10–20 %). Although air pollution over cities is largely determined by the local urban emissions, considerable (often a few tens of %) fraction of the concentration is attributable to other sources from rural areas and minor cities. For the case of Prague (Czech Republic capital), it is further shown that the inter-urban interference between large cities does not play an important role which means that the impact on a chosen city of emissions from all other large cities is very small. At last, it is shown that to achieve significant ozone reduction over cities in central Europe, the emission control strategies have to focus on the reduction of NMVOC, as reducing NOx (due to suppressed titration) often leads to increased O3. The influence over rural areas is however always in favor of improved air quality, i.e. both NOx and/or NMVOC reduction ends up in decreased ozone pollution, mainly in terms of exceedances.
Perspectives on contextual vulnerability in discourses of climate conflict
Authors: Okpara U. T. , Stringer L. C. , Dougill A. J. 
Published: February 2016

Abstract. The science of climate security and conflict is replete with controversies. Yet the increasing vulnerability of politically fragile countries to the security consequences of climate change is widely acknowledged. Although climate conflict reflects a continuum of conditional forces that coalesce around the notion of vulnerability, how different portrayals of vulnerability influence the discursive formation of climate conflict relations remains an exceptional but under-researched issue. This paper combines a systematic discourse analysis with a vulnerability interpretation diagnostic tool to explore (i) how discourses of climate conflict are constructed and represented, (ii) how vulnerability is communicated across discourse lines, and (iii) the strength of contextual vulnerability against a deterministic narrative of scarcity-induced conflict, such as that pertaining to land. Systematically characterising climate conflict discourses based on the central issues constructed, assumptions about mechanistic relationships, implicit normative judgements and vulnerability portrayals, provides a useful way of understanding where discourses differ. While discourses show a wide range of opinions "for" and "against" climate conflict relations, engagement with vulnerability has been less pronounced – except for the dominant context centrism discourse concerned about human security (particularly in Africa). In exploring this discourse, we observe an increasing sense of contextual vulnerability that is oriented towards a concern for complexity rather than predictability. The article concludes by illustrating that a turn towards contextual vulnerability thinking will help advance a constructivist theory-informed climate conflict scholarship that recognises historicity, specificity, and variability as crucial elements of contextual totalities of any area affected by climate conflict.
Intravitreal Aflibercept for Choroidal Neovascularization in Ocular Sarcoidosis
Authors: Querques Lea , Querques Giuseppe , Miserocchi Elisabetta , Modorati Giulio , Bandello Francesco 
Published: February 2016

Purpose To report a case of choroidal neovascularization (CNV) in a patient with ocular sarcoidosis treated by intravitreal aflibercept. Methods A 27-year old man was referred to our department because of sudden visual acuity decrease (best-corrected visual acuity (BCVA) was 20/80 LE). Fundus examination showed bilateral optic disk swelling, retinal pigment epithelium changes at the posterior pole, yellowish chorioretinal lesions in the periphery, and the presence of a prominent peripapillary neovascular complex. Results The clinical diagnosis was most compatible with ocular sarcoidosis, later confirmed by mediastinal lymph node biopsy. Fluorescein and indocyanine green angiography confirmed the presence of active peripapillary type 2 (classic) CNV in both eyes. Given that the exudation of the peripapillary CNV harmed the fovea, the patient underwent a single intravitreal aflibercept injection LE. One month after the treatment, LE BCVA decreased to 20/125. Spectral-domain optical coherence tomography (SD-OCT) showed complete resolution of subretinal fluid but revealed outer retinal atrophy with complete loss of the ellipsoid zone (EZ) in the macula (possibly responsible for visual acuity worsening). Six months later, LE BCVA slightly increased to 20/100, and SD-OCT showed partial recovery of the EZ in the macula. No adverse events related to the treatment were recorded during follow-up. Conclusions We report a case of CNV in a patient with ocular sarcoidosis treated with intravitreal aflibercept. In our experience, intravitreal aflibercept injection achieved morphologic resolution for sarcoid-related peripapillary CNV.
Cementless Total HIP Arthroplasty Using Biolox®Delta Ceramic-on-Ceramic Bearing in Patients with Osteonecrosis of the Femoral Head
Authors: Lim Seung-Jae , Kim Sang-Min , Kim Dong-Wook , Moon Young-Wan , Park Youn-Soo 
Published: February 2016

Purpose The purpose of this study was to evaluate the results of cementless total hip arthroplasty (THA) using a 32 mm or larger Biolox®delta ceramic-on-ceramic (CoC) bearing in patients with osteonecrosis of the femoral head after a minimum of 5 years of follow-up. Materials and methods We retrospectively analysed 44 patients (53 hips) who underwent cementless THA using Biolox®delta CoC bearing. There were 33 men (40 hips) and 11 women (13 hips) with the mean age of 49 years. A 36 mm head was used in 42 (79%) of 53 hips and a 32 mm head was used in 11 hips with smaller acetabular shells. The mean duration of follow-up was 5.3 years (range 5-6 years). Results The mean Harris Hip Score improved from 50 points preoperatively to 97 points at final follow-up (p<0.001). All acetabular and femoral components showed radiographic evidence of osseointegration. No osteolysis was observed. No patients sustained ceramic fracture. An audible hip noise was identified in 2 (4%) of the 53 hips (1 squeaking and 1 clicking). Survivorship with revision for any reason at a minimum of 5 years was 100% in the best-case scenario and 95 % in the worst-case scenario. Conclusions The minimum 5-year results of cementless THA using a 32 mm or larger Biolox®delta CoC bearing in patients with osteonecrosis of the femoral head were encouraging with excellent survivorship. However, it was also found that the risk of noise development remains even for the new alumina matrix composite ceramic.
Systemic Inflammatory Cytokine Analysis to Monitor Biomaterial Augmented Tissue Healing
Authors: Bryan Nicholas , Ashwin Helen , Smart Neil , Weyhe Dirk , Wohlert Stephen , Bayon Yves , Hunt John A. 
Published: February 2016

Purpose Hernias can be repaired by reinforcement of damaged fascia using biomaterials to provide stabilisation. Repair materials are usually porous, through which cells infiltrate, proliferate and secrete ECM. Their efficacy relies on good tissue integration and resolution of host defence mechanisms. Therefore, understanding the dynamics by which biomaterials interact with tissue will provide knowledge to advance prosthesis design. Furthermore, determining host response in real time would provide significant advantage both clinically and scientifically over the current terminal process of histology. Methods 3 materials comprising synthetic and composite (synthetic materials hybridised with a resorbable biologic component) meshes were implanted into a rat full-thickness abdominal wall excision model. Their efficacy was evaluated using histopathology whilst also monitoring systemic concentrations of cytokines associated with inflammation and wound healing to predict material outcome over 12 weeks. Results The noncomposite material (polyester) and Material B (polypropylene mesh with oligocaprone film and polydioxanone glue) stimulated the largest degree of adhesion from the 3 materials tested, although after 28 days adhesions were stronger to Material B. Histologically, all 3 materials integrated well with abdominal musculature and infiltrated completely with cells. Conclusions Analysis of systemic inflammation biomarkers confirmed inflammation elicited by surgeries and meshes irrespective of their composition. However, at an early postoperative endpoint (i.e., 1 week), some biomarkers, namely, IL-18 and RANTES, appeared to discriminate the noncomposite mesh from the composite materials, although in this study all materials successfully repaired the defects without recurrence or external indicators of postoperative chronic pain.
Predictive Models for Arteriovenous Fistula Maturation
Authors: Al Shakarchi Julien , McGrogan Damian , Van der Veer Sabine , Sperrin Matthew , Inston Nicholas 
Published: February 2016

Purpose Haemodialysis (HD) is a lifeline therapy for patients with end-stage renal disease (ESRD). A critical factor in the survival of renal dialysis patients is the surgical creation of vascular access, and international guidelines recommend arteriovenous fistulas (AVF) as the gold standard of vascular access for haemodialysis. Despite this, AVFs have been associated with high failure rates. Although risk factors for AVF failure have been identified, their utility for predicting AVF failure through predictive models remains unclear. The objectives of this review are to systematically and critically assess the methodology and reporting of studies developing prognostic predictive models for AVF outcomes and assess them for suitability in clinical practice. Methods Electronic databases were searched for studies reporting prognostic predictive models for AVF outcomes. Dual review was conducted to identify studies that reported on the development or validation of a model constructed to predict AVF outcome following creation. Data were extracted on study characteristics, risk predictors, statistical methodology, model type, as well as validation process. Results We included four different studies reporting five different predictive models. Parameters identified that were common to all scoring system were age and cardiovascular disease. Conclusions This review has found a small number of predictive models in vascular access. The disparity between each study limits the development of a unified predictive model.
Comparison of Intensive versus Standard Hemodialysis Central Venous Catheter Dysfunction Protocol Using rt-PA: A Quality Assurance Initiative
Authors: Wilson Jo-Anne S. , Mossop Paula , Soroka Steven D. , Dipchand Christine , Drost Sarah , Sheehy Niall , Tennankore Karthik 
Published: February 2016

Purpose Catheter locking solutions such as recombinant tissue plasminogen activator (rt-PA) are used to treat and prevent clotting of hemodialysis (HD) catheters during HD treatments and the interdialytic period. However, evidence to guide the use of rt-PA for catheter dysfunction is limited. Methods We evaluated outcomes using two catheter dysfunction protocols in a cohort of consecutive prevalent dialysis patients (Jan 2013 to Sep 2014) undergoing HD with a tunneled catheter. In the intensive protocol, rt-PA was administered to all catheters based on blood flow and/or line reversal. In the standard protocol, rt-PA administration was based only on blood flow. The primary outcome was the rate of rt-PA use for catheter malfunction (rt-PA treatment days/1000 total line days; [TLD]). Secondary outcomes included the cost of rt-PA/TLD and the rate of catheter-related bacteremia. Results There were 26 and 35 patients managed by the intensive and standard protocols, respectively. The rate of rt-PA use was 52/1000 TLD (intensive) versus 39/1000 TLD (standard) (rate ratio 1.30, 95% CI 1.12-1.52 CI, p<0.001). The rate of bacteremia was 0.43 and 0.22/1000 TLD for the intensive and standard protocols, respectively (p = 0.491). The cost of rt-PA was CDN $5.58 and CDN $6.15 per TLD for the intensive protocol and standard protocol groups (p<0.001). Conclusions Managing catheter dysfunction based on line reversal and blood flow as opposed to only blood flow was associated with a higher rate of rt-PA use, but at a reduced overall cost.