bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEITO DE 6-BENZILAMINOPURINA E ÁCIDO NAFTALENOACÉTICO SOBRE A PROPAGAÇÃO in vitro DE Hancornia speciosa
Authors: Oliveira Kívia Soares de , Freire Fúlvio Aurélio de Morais , Aloufa Magdi Ahmed Ibrahim 
Published: October 2016

A mangabeira (Hancornia speciosa Gomes) é uma espécie arbórea nativa do Nordeste, de grande importância socioeconômica, ambiental e medicinal. Na última década, a intensificação da ação antrópica vem contribuindo para a redução significativa de suas áreas remanescentes, e, consequentemente, de sua diversidade genética, o que justifica a realização de estudos relacionados à propagação da espécie. O objetivo deste trabalho foi testar o efeito de diferentes concentrações de 6-benzilaminopurina (BAP) e ácido naftalenoacético (ANA) sobre a indução de brotações em explantes nodais de mangabeira. Estes foram obtidos de plântulas germinadas in vitro e inoculados em meio MS básico e MS suplementado com: 1,5; 2,5 e 3,5 mg.L-1 de BAP e 0,1 e 0,5 mg.L-1 de ANA e mantidos em sala de crescimento, durante 30 dias sob condições controladas de temperatura, fotoperíodo e luminosidade. O delineamento experimental utilizado foi o inteiramente casualizado com doze tratamentos, e três repetições, sendo cada repetição composta por 10 unidades experimentais. As variáveis observadas foram: formação de brotos, número de brotos por explante, presença de calos, contaminação e sobrevivência. Os dados foram avaliados estatisticamente através da análise de modelo linear generalizado. Os resultados indicaram diferença significativa entre os tratamentos com os reguladores de crescimento vegetal, para todas as variáveis. Dessa forma, na ausência de BAP e ANA os explantes apresentam-se mais responsivos em relação à taxa de multiplicação e ao número de brotações, sendo, portanto, desnecessário o uso desses reguladores de crescimento para a propagação in vitro de mangabeira.
Memoria de la prisión de mujeres de les Corts. Un balance (2006-2014)
Authors: Hernández Holgado Fernando 
Published: October 2016

Este artículo pretende hacer un balance de la labor desarrollada por el portal web Memòria de la presó de dones de Les Corts –wwwpresodelescorts.org- presentado en 2006 en Barcelona por la Associació per la Cultura i la Memòria de Catalunya (ACMe) y todavía en activo. El texto consta de dos partes. En la primera, se describe el proyecto situándolo en el campo de la historia pública, la historia digital y la historial oral. La segunda se refiere más concretamente a las actividades realizadas durante todos estos años: desde las de difusión pedagógica –su presentación en escuelas e institutos- hasta las de participación ciudadana, con la dinamización de un proceso participativo de señalización, actualmente en marcha, que se materializaría en un futuro monumento en el antiguo solar de la cárcel, en el barrio barcelonés de Les Corts.
La perspective d’indépendance judiciaire à travers la poursuite privée dans le contexte de lutte contre la corruption
Authors: Hemle Djob Sotong Simon Pierre 
Published: October 2016

Une lecture des conventions internationales de lutte contre la corruption, sous le prisme de l’indépendance judiciaire, subordonne la validité de ce principe à deux conditions : il faut, dans un premier temps, que le statut du ministère public soit identique au statut du juge ; il faut, dans un second temps, faciliter les conditions d’accès du poursuivant privé à la justice. Telle est, entre autres, la substance des articles 11 (2) et 13 de la Convention des Nations Unies contre la corruption, et de l’article 5 de la Convention sur la lutte contre la corruption dans les transactions commerciales internationales de l’Organisation de coopération et de développement économiques (OCDE). Il suit de ce qui précède qu’une réception littérale des instruments internationaux de lutte contre la corruption peut nécessiter de lourdes réformes institutionnelles, voire des modifications constitutionnelles. Toutefois, l’article qui suit montre que tout État partie aux conventions sus évoquées peut faire l’économie desdites réformes en substituant l’analyse positiviste des fonctions judiciaires à une réception pragmatique de l’activité judiciaire. Une telle solution exige que les fonctions judiciaires soient clairement différenciées des autres fonctions de l’État contemporain (postmoderne).
Design of reconfigurable on-chip mode filters based on phase transition in vanadium dioxide
Authors: Huang Tianye , Pan Zepeng , Zhang Minming , Fu Songnian 
Published: October 2016

Abstract
On the basis of the phase transition between an insulator and a metal in vanadium dioxide (VO2), we propose ultracompact and broadband lower- and higher-order mode pass filters (LOMPF and HOMPF, respectively) for a multimode silicon waveguide supporting two transverse electric (TE) modes. Good performance of mode filtering can be maintained over a wavelength range of 100 nm. In addition, the two filters can be cascaded to achieve reconfigurable operation for both TE00 and TE01 modes, including TE00-pass, TE01-pass, all-pass, and all-block. The reconfigurable response of the proposed on-chip mode filter is helpful for flexible mode-division multiplexing applications.
Measuring stiffness and residual stress of thin films by contact resonance atomic force microscopy
Authors: Ma Chengfu , Chen Yuhang , Chen Jianfeng , Chu Jiaru 
Published: October 2016

Abstract
A method based on contact resonance atomic force microscopy (AFM) was proposed to determine the mechanical properties of thin films. By analyzing the contact resonance frequencies of an AFM probe while the tip was in contact with the sample, the stiffness and residual stress of a freestanding circular SiN
x
membrane were evaluated quantitatively. The obtained magnitude of residual stress was in reasonable agreement with that determined by wafer curvature measurement. The method was verified to have much better mechanical sensitivity than the popular AFM bending test method. Its promising application to fast, nondestructive mechanical mapping of thin-film-type structures at the nanoscale was also demonstrated.
Population structure and association analysis of yield and grain quality traits in hybrid rice primal parental lines
Authors: Wang Yingheng , Zheng Yanmei , Cai Qiuhua , Liao Changjian , Mao Xiaohui , Xie Hongguang , Zhu Yongsheng , Lian Lin , Luo Xi , Xie Huaan , Zhang Jianfu 
Published: October 2016

AbstractTo make advances in rice molecular design breeding, it is important to understand the genetic background and phenotypes of the parental lines, to known superior allele of the breeding material. In this study, 34 pairs of insertion-deletion (InDel) markers were used to analyze the differentiation of indica–japonica properties in 277 primal parental lines of hybrid rice that are used in China and abroad. The genetic diversity and population structure were assessed with simple sequence repeat (SSR) markers. We also evaluated the association between SSR markers and seven yield traits and four grain-quality traits of 256 indica rice lines. The main results are as follows. (1) Within the 277 lines there were two subgroups: indica and japonica. The 256 lines of the indica-subgroup were further divided into four sub–sub-groups: landrace, maintainer, restorer, and rice lines from the International Rice Research Institute. (2) We identified 29 loci associated with 11 agronomic traits, including one for plant height, two for tiller number, one for panicle length, three for grain length, eight for grain width, eight for grain length/width ratio, one for thousand grain weight, one for amylose content, two for gel consistency, one for gelatinization temperature and one for total protein content. (3) Among those loci, 16 markers were closely linked to previously identified genes. Superior allele carrier lines and allele effects were also analyzed. Our results provided the population structure and indica–japonica properties for parent matching, and the marker–trait association will also be useful for molecular design breeding.
Diversity‐productivity dependent resistance of an alpine plant community to different climate change scenarios
Authors: Ali Arshad , Molau Ulf , Bai Yang , Jägerbrand Annika K. , Alatalo Juha M. 
Published: October 2016

AbstractHere we report from a experiment imposing different warming scenarios [control with ambient temperature, constant level of moderate warming for 3 years, stepwise increase in warming for 3 years, and one season of high level warming (pulse) simulating an extreme summer event] on an alpine ecosystem to study the impact on species diversity–biomass relationship, and community resistance in terms of biomass production. Multiple linear mixed models indicate that experimental years had stronger influence on biomass than warming scenarios and species diversity. Species diversity and biomass had almost humpback relationships under different warming scenarios over different experimental years. There was generally a negative diversity–biomass relationship, implying that a positive diversity–biomass relationship was not the case. The application of different warming scenarios did not change this tendency. The change in community resistance to all warming scenarios was generally negatively correlated with increasing species diversity, the strength of the correlation varying both between treatments and between years within treatments. The strong effect of experimental years was consistent with the notion that niche complementarity effects increase over time, and hence, higher biomass productivity over experimental years. The strongest negative relationship was found in the first year of the pulse treatment, indicating that the community had weak resistance to an extreme event of one season of abnormally warm climate. Biomass production started recovering during the two subsequent years. Contrasting biomass‐related resistance emerged in the different treatments, indicating that micro sites within the same plant community may differ in their resistance to different warming scenarios.
Statistical Analysis of Optimal Ultrasound Emulsification Parameters in Thistle‐Oil Nanoemulsions
Authors: Miastkowska Małgorzata A. , Banach Marcin , Pulit‐Prociak Jolanta , Sikora Elżbieta S. , Głogowska Agata , Zielina Michał 
Published: October 2016

AbstractThistle oil (INCI: Silybum marianum seed oil) is known as an anti‐oxidant, moisturizing and skin regenerating cosmetic raw material. Nanoemulsions are a new form of cosmetic product showing very good user properties (ease of spreading over the skin with no greasy feeling). Moreover, due to their structure, they can also transport both hydrophilic and hydrophobic active substances to the skin. The aim of this work was the preparation and characterization of nanoemulsions, based on thistle oil. The non‐ionic surfactants polysorbate 80 (PEG‐20 sorbitan monooleate), decyl glucoside, and a polyglyceryl‐4 ester blend were applied to stabilize the nanosystems. All formulations were obtained by a high energy method, using an ultrasonic device (Labsonic U, an ultrasound homogenizer). Variations in the emulsification parameters were tested, including surfactants concentration, pre‐emulsification time, ultrasound power and sonication time. On the basis of statistical analysis (experimental design, cluster analysis, classification and regression trees) the best emulsification process parameters were determined. In order to verify the results of statistical analysis, once more an experimental study was conducted. The results obtained confirmed that statistical analysis can be a useful method in determining the conditions for obtaining stable nanoemulsions with desired properties. Formulations obtained with the use of Silybum marianum seed oil were characterized by long‐term stability, a low polydispersity index, low viscosity and an average droplet size less than 200 nm.
Negative emotional reactivity moderates the relations between family cohesion and internalizing and externalizing symptoms in adolescence☆
Authors: Rabinowitz Jill A. , Osigwe Ijeoma , Drabick Deborah A.G. , Reynolds Maureen D. 
Published: October 2016

ABSTRACTLower family cohesion is associated with adolescent internalizing and externalizing problems. However, there are likely individual differences in youth's responses to family processes. For example, adolescents higher in negative emotional reactivity, who often exhibit elevated physiological responsivity to context, may be differentially affected by family cohesion. We explored whether youth's negative emotional reactivity moderated the relation between family cohesion and youth's symptoms and tested whether findings were consistent with the diathesis‐stress model or differential susceptibility hypothesis. Participants were 651 adolescents (M = 12.99 ± .95 years old; 72% male) assessed at two time points (Time 1, ages 12–14; Time 2, age 16) in Pittsburgh, PA. At Time 1, mothers reported on family cohesion and youth reported on their negative emotional reactivity. At Time 2, youth reported on their symptoms. Among youth higher in negative emotional reactivity, lower family cohesion predicted higher symptoms than higher family cohesion, consistent with the diathesis‐stress model.
Defining imaging biomarker cut points for brain aging and Alzheimer's disease
Authors: Jack Clifford R. , Wiste Heather J. , Weigand Stephen D. , Therneau Terry M. , Lowe Val J. , Knopman David S. , Gunter Jeffrey L. , Senjem Matthew L. , Jones David T. , Kantarci Kejal , Machulda Mary M. , Mielke Michelle M. , Roberts Rosebud O. , Vemuri Prashanthi , Reyes Denise A. , Petersen Ronald C. 
Published: October 2016

AbstractIntroductionOur goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro‐deoxyglucose (FDG) PET, and MRI cortical thickness.MethodsWe examined five methods for determining cut points.ResultsThe reliable worsening method produced a cut point only for amyloid PET. The specificity, sensitivity, and accuracy of cognitively impaired versus young clinically normal (CN) methods labeled the most people abnormal and all gave similar cut points for tau PET, FDG PET, and cortical thickness. Cut points defined using the accuracy of cognitively impaired versus age‐matched CN method labeled fewer people abnormal.DiscussionIn the future, we will use a single cut point for amyloid PET (standardized uptake value ratio, 1.42; centiloid, 19) based on the reliable worsening cut point method. We will base lenient cut points for tau PET, FDG PET, and cortical thickness on the accuracy of cognitively impaired versus young CN method and base conservative cut points on the accuracy of cognitively impaired versus age‐matched CN method.
Can curcumin modulate allergic rhinitis in rats?
Authors: Acar M , Muluk N Bayar , Yigitaslan S , Cengiz B P , Shojaolsadati P , Karimkhani H , Ada S , Berkoz M , Cingi C 
Published: October 2016

AbstractObjectives:This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats.Methods:Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21–28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21–28. Allergy symptoms and histopathological features of the nasal mucosa were examined.Results:The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria.Conclusion:Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.
The role of chemokines and their receptors during protist parasite infections
Authors: MENZIES FIONA M. , MACPHAIL DAVID , HENRIQUEZ FIONA L. 
Published: October 2016

SUMMARYProtists are a diverse collection of eukaryotic organisms that account for a significant global infection burden. Often, the immune responses mounted against these parasites cause excessive inflammation and therefore pathology in the host. Elucidating the mechanisms of both protective and harmful immune responses is complex, and often relies of the use of animal models. In any immune response, leucocyte trafficking to the site of infection, or inflammation, is paramount, and this involves the production of chemokines, small chemotactic cytokines of approximately 8–10 kDa in size, which bind to specific chemokine receptors to induce leucocyte movement. Herein, the scientific literature investigating the role of chemokines in the propagation of immune responses against key protist infections will be reviewed, focussing onPlasmodiumspecies,Toxoplasma gondii, Leishmaniaspecies andCryptosporidiumspecies. Interestingly, many studies find that chemokines can in fact, promote parasite survival in the host, by drawing in leucocytes for spread and further replication. Recent developments in drug targeting against chemokine receptors highlights the need for further understanding of the role played by these proteins and their receptors in many different diseases.
Contaminations of inner surface of magnesium fluoride windows in the ‘Expose-R’ experiment on the International Space Station
Authors: Skurat V. E. 
Published: October 2016

AbstractA series of experiments was carried out previously on board of the International Space Station in ‘EXPOSE-R’, a multi-user expose facility, provided by European Space Agency attached to the external surface of the Russian Segment. In one experiment, spores of microorganisms and species of higher plant seeds, in heat-sealed polymer bags were irradiated by solar radiation passed through MgF2windows in a high space vacuum. After sample exposure, it was found that in many cases the inner surfaces of windows were contaminated. Analysis of the contamination revealed the presence of chemical groups CH2, CH3, NH, OH, C═O, Si–CH3(Demetset al.in 2015). Their presence in deposits was explained by photofixation of gaseous precursors – some of the vapours of glues and additives in polymeric materials in the core facility of ‘Expose-R’. Carbon-, oxygen- and silicon-containing groups may be deposited from outer intrinsic atmosphere. This atmosphere is connected with sample compartments and core facility. However, the presence of NH groups on inner surfaces of windows was not expected. This paper shows that the process responsible for carbon-, nitrogen- and oxygen-containing group formation can be a photopolymerization of caprolactam, which is released from the outer Nylon 6 layer of polymer bags under Solar vacuum ultraviolet radiation.
P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy
Authors: Jia Yu-Li , Xu Meng , Dou Chang-Wei , Liu Zhi-Kui , Xue Yu-Mo , Yao Bo-Wen , Ding Ling-Long , Tu Kang-Sheng , Zheng Xin , Liu Qing-Guang 
Published: October 2016

AbstractAberrant autophagic processes have been found to have fundamental roles in the pathogenesis of different kinds of tumors, including hepatocellular carcinoma (HCC). P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), performs its function by acetylating both histone and non-histone proteins. Our previous studies showed that PCAF was downregulated in HCC tissues and its high expression was significantly associated with patient survival after surgery, serving as a prognostic marker. In this study we found that overexpression of PCAF induced autophagy of HCC cells and its knockdown depressed autophagy. As type II programmed cell death, autophagy induced by PCAF-elicited cell death in HCC cells. In vivo experiments confirmed that PCAF-induced autophagy inhibited tumor growth. Subsequent in vitro experiments showed that PCAF promoted autophagy by inhibiting Akt/mTOR signaling pathway. Our findings show that PCAF is a novel modulator of autophagy in HCC, and can serve as an attractive therapeutic strategy of HCC treatment.
Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB
Authors: Cui Xiaolan , Chen Qian , Dong Zhen , Xu Longmei , Lu Tianfei , Li Dawei , Zhang Jiangjun , Zhang Ming , Xia Qiang 
Published: October 2016

AbstractSirtuin 1 (Sirt1) is a deacetylase that regulates many cellular processes in the liver, and so far its role in endotoxemic liver injury is elusive. So we conditionally inactivate Sirt1 in murine hepatocytes to determine its role in d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver damage, which is a well-established experimental model mimicking septic liver injury and fulminant hepatitis. Ablation of Sirt1 shows remarkable protection against GalN/LPS-induced liver injury, which is a result of enhanced NF-κB response because knockdown of RelA/p65 negates the protective effect of Sirt1 knockout. Mechanistically, NF-κB p65 is maintained in a hyperacetylated, DNA-binding competent state in tumor necrosis factor-α (TNF-α)-challenged albumin-Cre+ (AlbCre+) hepatocytes. Transfection of hepatocytes with a recombinant acetylated p65 expression construct replicates the protection afforded by Sirt1 knockout. Transfection of AlbCre+ hepatocytes with a recombinant wild-type Sirt1 construct, rather than a deacetylase-defective one, compromises NF-κB activation and resensitizes hepatocytes to TNF-α-induced apoptosis. Taken together, our results demonstrate that Sirt1 deacetylates p65 and compromises NF-κB activity in hepatocytes when confronted with LPS/TNF-α stimulation, leading to increased susceptibility to endotoxemic injury. These findings identify a possible protein effector to maneuver the hepatic NF-κB signaling pathway under inflammatory circumstances and a feasible way to increase hepatocellular resistance to endotoxin/TNF-α toxicity.
Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes
Authors: de Peralta Mauro S Porcel , Mouguelar Valeria S , Sdrigotti María Antonella , Ishiy Felipe A A , Fanganiello Roberto D , Passos-Bueno Maria R , Coux Gabriela , Calcaterra Nora B 
Published: October 2016

AbstractTreacher Collins Syndrome (TCS) is a rare congenital disease (1:50 000 live births) characterized by craniofacial defects, including hypoplasia of facial bones, cleft palate and palpebral fissures. Over 90% of the cases are due to mutations in the TCOF1 gene, which codifies the nucleolar protein Treacle. Here we report a novel TCS-like zebrafish model displaying features that fully recapitulate the spectrum of craniofacial abnormalities observed in patients. As it was reported for a Tcof1+/− mouse model, Treacle depletion in zebrafish caused reduced rRNA transcription, stabilization of Tp53 and increased cell death in the cephalic region. An increase of ROS along with the overexpression of redox-responsive genes was detected; furthermore, treatment with antioxidants ameliorated the phenotypic defects of craniofacial anomalies in TCS-like larvae. On the other hand, Treacle depletion led to a lowering in the abundance of Cnbp, a protein required for proper craniofacial development. Tcof1 knockdown in transgenic zebrafish overexpressing cnbp resulted in barely affected craniofacial cartilage development, reinforcing the notion that Cnbp has a role in the pathogenesis of TCS. The cnbp overexpression rescued the TCS phenotype in a dose-dependent manner by a ROS-cytoprotective action that prevented the redox-responsive genes’ upregulation but did not normalize the synthesis of rRNAs. Finally, a positive correlation between the expression of CNBP and TCOF1 in mesenchymal cells from both control and TCS subjects was found. Based on this, we suggest CNBP as an additional target for new alternative therapeutic treatments to reduce craniofacial defects not only in TCS but also in other neurocristopathies.