bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfataan Limbah sebagai Hidroponik dan Pupuk Organik Cair di Desa Sumber Sari, Kutai Barat
Authors: Kuspradini Harlinda , Putri Agmi Sinta , Lesmana Danang Surya , Mustapa Fredrik Christhio , Zakiah Nurul , Wulandari Rahma 
Published: October 2024

ABSTRACTIncreasing public knowledge regarding waste management is an important value to be able to reduce the impact of environmental pollution, especially in residential areas. For this reason, this service activity aims to (1) analyze the problems that exist in Sumber Sari Village related to community welfare, (2) create new job opportunities through waste management education. Community service activities were carried out by mapping the problems in Sumber Sari Village through online discussions. The expected output from this service activity is the creation of new job opportunities and an increase in the economic level through the education provided. Community empowerment through this activity can increase the community's knowledge of Sumber Sari Village to be able to improve their welfare and have a positive impact both directly and indirectly. Keywords: Waste, Organic fertilizer, Hydroponics, West Kutai ABSTRAKPeningkatan pengetahuan masyarakat terkait pengolahan limbah menjadi nilai penting untuk dapat mengurangi dampak pencemaran lingkungan khususnya di area pemukiman. Untuk itu kegiatan pengabdian ini bertujuan untuk (1) menganalisa permasalahan yang ada di Desa Sumber Sari terkait kesejahteraan masyarakat, (2) menciptakan peluang lapangan pekerjaan baru melalui edukasi pengolahan limbah. Kegiatan pengabdian dilakukan dengan pemetaan masalah yang ada di Desa Sumber Sari melalui diskusi secara online. Luaran yang diharapkan dari kegiatan pengabdian ini yaitu terciptanya peluang kerja baru dan peningkatan taraf ekonomi melalui edukasi-edukasi yang diberikan. Pemberdayaan masyarakat melalui kegiatan ini dapat meningkatkan pengetahuan masyarakat Desa Sumber Sari untuk dapat meningkatkan kesejahteraannya dan memberikan dampak positif baik dalam secara langsung maupun tidak langsung. Kata Kunci: Limbah, Pupuk organik, Hidroponik, Kutai Barat
Pemberdayaan Masyarakat melalui Pelatihan Budidaya Hidroponik Sayuran sebagai Upaya Pembentukan Agropreneur Muda
Authors: Istiqomah Istiqomah , Shoimah Siti , Setiawan Ridho Bagus , Ardiansyah Syaiful Amin , Sholikhatus Nur Vinda Eka 
Published: October 2024

One of the important community empowerment to be developed is the expertise in the field of entrepreneurship, especially in agriculture, which is called agropreneur. Entrepreneurship in agriculture has recently become something that people are aware of along with the increasing demand for food and vegetables. Hydroponics is an alternative to plant cultivation using simple technology that makes it easier for people to grow crop. especially vegetables. Hydroponic cultivation training is aimed to young people in the hope of being able to motivate and initiate the formation of entrepreneurs in agricultural sector (agriprenuership). This program employed several stages; potential observation, socialization, training, program assistance, and final assessment. The results showed that: (1) 100 percent of the hydroponic cultivation training participants understand the theory and practice of hydroponic vegetable cultivation, (2) Lettuce plants from the training program were normal in size and freshness. The level of lettuce leaf damage caused by pests and diseases is low. Lettuce produced from this training program is suitable for consumption and commercial marketing. Salah satu pemberdayaan masyarakat yang penting untuk dikembangkan adalah keahlian bidang wirausaha khususnya di bidang pertanian yang disebut sebagai agropreneur. Kewirausahaan di bidang pertanian belakangan ini menjadi hal yang disadari masyarakat seiring dengan meningkatkan kebutuhan akan pangan dan sayuran. Hidroponik merupakan alternatif budidaya tanaman dengan menggunakan teknologi yang sederhana umtuk memudahkan masyarakat dalam bercocok tanam, terutama jenis sayuran. Pelatihan budidaya hidroponik ditujukan bagi kalangan muda dengan harapan mampu memotivasi dan menginiasi terbentuknya wirausahawan bidang pertanian (agropreneurship). Metode pelaksanaan pengabdian yang digunakan dalam program ini adalah observasi potensi, sosialisasi, pelatihan, pendampingan program, dan asesmen akhir. Hasil pengabdian masyarakat ini adalah: (1) 100 persen peserta pelatihan budidaya hidroponik memahami secara teori dan praktik tentang budidaya tanaman sayuran secara hidroponik, (2) Tanaman selada hasil program pelatihan memiliki ukuran dan kesegaran yang normal. Tingkat kerusakan daun selada akibat setangan hama dan penyakit adalah rendah. Selada yang dihasilkan dari program pelatihan ini layak dikonsumi dan dipasarkan secara komersil.
Improvement of Intrapreneurship Behavior in Higher Education
Authors: Yulia Novie Rachma , Iriani Sri Setyo , Witjaksono Andre Dwijanto , Wulandari Siti Sri 
Published: October 2024

Abstract: Educational Development Contribution is no longer the only source of income from universities. Universities are expected to have a Business Center as a solution to overcome financing problems and increase income as well as welfare for organizational members within the university. This Business Center can run if members of the organization have an entrepreneurial spirit and intrapreneurship behavior. This research aims to explore the transformational leadership style and entrepreneurial character as factors that can increase intrapreneurship behavior (Behavioral Intrapreneurship) in organizational members at a private university located in West Surabaya. The research uses a qualitative method with a case research approach and quantitative by the percentage method for descriptive analysis on each variable. In-depth interviews were conducted with key informants and questionnaires for other respondents. This is intended to be able to explore phenomena that exist in the field. The results of this research indicate that the rector at the university has a transformational leadership style while the lecturers and employees at the university have an entrepreneurial character and intrapreneur behavior. This research concludes that the transformational leadership style of the leader contributes to the formation of intrapreneurship behavior in the university environment. Abstrak: Kontribusi Pengembangan Pendidikan bukan lagi satu-satunya sumber pendapatan dari perguruan tinggi. Perguruan tinggi diharapkan memiliki Pusat bisnis sebagai solusi untuk mengatasi masalah pembiayaan dan meningkatkan pendapatan serta kesejahteraan bagi anggota organisasi di lingkungan perguruan tinggi. Pusat Bisnis ini dapat berjalan jika anggota organisasi memiliki jiwa kewirausahaan dan perilaku intrapreneurship. Penelitian ini bertujuan untuk mengeksplorasi gaya kepemimpinan transformasional dan karakter wirausaha sebagai faktor yang dapat meningkatkan perilaku intrapreneurship (Behavioral Intrapreneurship) pada anggota organisasi pada sebuah perguruan tinggi swasta yang berlokasi di Surabaya Barat. Penelitian ini menggunakan metode kualitatif dengan pendekatan penelitian kasus dan kuantitatif dengan metode persentase untuk analisis deskriptif pada masing-masing variabel. Wawancara mendalam dilakukan dengan informan kunci dan kuesioner kepada responden lain. Hal ini dimaksudkan untuk dapat menggali fenomena-fenomena yang ada di lapangan. Hasil penelitian ini menunjukkan bahwa rektor di universitas memiliki gaya kepemimpinan transformasional sedangkan dosen dan karyawan di universitas memiliki karakter kewirausahaan dan perilaku intrapreneur. Penelitian ini menyimpulkan bahwa gaya kepemimpinan transformasional pemimpin berkontribusi terhadap pembentukan perilaku intrapreneurship di lingkungan universitas.
Avifauna associated to a home garden in Valladolid, Yucatan, Mexico
Authors: Guzmán Canul Alex Ricardo , Sánchez-Soto Saúl 
Published: October 2024

Objective: To identify the birds associated to a home garden in Valladolid, Yucatan, Mexico, and to understand which ones use cultivated plants as food.Methodology: As part of the project “Fauna associated to cultivated plants in the south-southeast region of Mexico”, 36 field visits were carried out, for six hours per day (6:00-10:00 and 16:00-18:00 hrs.), in the period from March 2022 to April 2023, in a home garden in Valladolid, Yucatan. The birds were watched with binoculars, photographed with digital cameras, and identified with field guides.Results: A total of 67 bird species were observed, which belonged to 14 orders and 28 families. Of the species, 14 are migratory, three endemic, and four subject to special protection in Mexico. In addition, 21 bird species were found feeding off 22 species of cultivated plants. The most frequently used plant resource by the birds were fruits (16), followed by nectar (5) and tender leaves (1). The most consumed plants species by the birds were Manilkara zapota (L.) P. Royen, Carica papaya L. and Spondias purpurea L., which were used by three bird species each. The bird that consumed more cultivated plants was the Golden-fronted Woodpecker (Melanerpesaurifrons Wagler) that fed off five species.Limitations on study: It was not possible to identify two birds at the species level: Contopus sp. and Myiarchus sp.Conclusions: This study contributes to the knowledge of birds associated to home gardens and constitutes the basis for future studies on bird-plant trophic interactions in Mexico.
Beneficios del ejercicio en las enfermedades cardiometabólicas
Authors: Insignares Ivan , Roca Rosa , Garcés Barraza Juan David 
Published: October 2024

Introducción: las enfermedades cardiometabólicas representan una tasa de mortalidad significativa, afectando hasta 41 millones de personas en todo el mundo, con un impacto especialmente notable entre los 30 y 69 años. Recientemente, se ha documentado que la falta de actividad física es un factor de riesgo importante para el desarrollo de estas enfermedades, contribuyendo a 1.6 millones de muertes anuales. Objetivo: analizar el impacto beneficioso del ejercicio en las enfermedades cardiometabólicas, explicando los mecanismos celulares y fisiológicos que contribuyen a la regulación de la homeostasis corporal y su influencia en la longevidad. Metodología: se realizó una revisión narrativa utilizando las bases de datos PUBMED, Science Direct, LILACS y SciELO para identificar artículos relevantes. No se establecieron límites en cuanto a la fecha de publicación. Se incluyeron artículos en inglés y español, estudios observacionales de casos y controles, investigación analítica experimental y no experimental. utilizando las teminos MeSH según el resumen, para un resultado final de 58 artículos que cumplieron la elegibilidad en la revisión al ser artículos que mostraban la relación del ejercicio en las enfermedades cardiometabólicas. Conclusión: las enfermedades cardiometabólicas tienen un gran impacto a nivel mundial y representan un alto costo para los sistemas de salud. El ejercicio físico ha demostrado ser una intervención crucial para prevenir o retrasar el curso de estas enfermedades a través de diversos mecanismos celulares que regulan la homeostasis corporal.
A novel liquid biopsy assay for detection of ERBB2 (HER2) amplification in circulating tumor cells (CTCs)
Authors: Di Caro Giuseppe , Lam Ernest , Bourdon David , Blankfard Martin , Dharajiya Nilesh , Slade Megan , Williams Emily , Zhang Dong , Wenstrup Rick , Schwartzberg Lee 
Published: October 2024

Purpose: Circulating tumor cell (CTC)-based ERBB2 (HER2) assay is a laboratory test developed by Epic Sciences using single-cell genomics to detect ERBB2 (HER2) amplification in CTCs found in the peripheral blood of metastatic breast cancer (MBC) patients.
Patients and methods: Peripheral blood was collected in Streck tubes and centrifugation was used to remove plasma and red blood cells. The remaining nucleated cells were deposited on glass slides, immunofluorescent-stained with proprietary antibodies, scanned by a high-definition digital scanner, and analyzed by a proprietary algorithm. In addition, single-cell genomics was performed on selected CTC. Analytical validation was performed using white blood cells from healthy donors and breast cancer cell lines with known levels of ERBB2 amplification. Clinical concordance was assessed on MBC patients whose blood was tested by the CTC ERBB2 (HER2) assay and those results are compared to results of matched metastatic tissue biopsy (immunohistochemistry [IHC] 3+ or IHC2+/in situ hybridization [ISH+]).
Results: Epic’s ERBB2 (HER2) assay detected 2-fold ERBB2 amplification with 85% sensitivity and 94% specificity. In the clinical concordance study, among the 50% of the cases that had ERBB2 status results from CTCs found to be chromosomally-unstable, the CTC ERBB2 (HER2) assay showed sensitivity of 69% and specificity of 78% when compared to HER2 status by metastatic tissue biopsy.
Conclusions: The CTC ERBB2 (HER2) assay can consistently detect ERBB2 status in MBC cell lines and in the population of patients with MBC with detectable chromosomally unstable CTCs for whom tissue biopsy is not available or is infeasible.
Genome-wide mapping uncovers significant quantitative trait loci associated with yam mosaic virus infection, yield and dry matter content in White Guinea yam (Dioscorea rotundata Poir.)
Authors: Adjei Emmanuel Amponsah , Odong Thomas Lapaka , Esuma Williams , Bhattacharjee Ranjana , Agre Paterne Angelot , Adebola Patrick Olusanmi , Chamba Emmanuel Boache , Asfaw Asrat , Dramadri Isaac Onziga , Mbabazi Sharon Tusiime , Edema Richard , Ozimati Alfred Adebo , Ochwo-Ssemakula Mildred , Alicai Titus 
Published: October 2024

IntroductionYam is an important crop for food security in East and West Africa due to its high market value and customer demand. High tuber quality with yield and disease resistance are the main traits for acceptability of yam cultivars across the tropical zone. There has been limited progress in enhancing the production and quality traits of yams, despite the significant socio-economic significance of this crop.MethodTo expedite the development of high-quality yam cultivars in Uganda, traits association study was conducted to identify genomic regions associated with key traits such as disease resistance, high yields, and dry matter content. The association mapping was conducted with multi-random mixed linear model (mrMLM) to compute the associations using five genetic models.ResultsA total of 16 significant single nucleotide polymorphisms (SNPs) markers were identified to be associated with the traits studied. Gene identification analysis revealed the presence of key putative genes such as Vicilin-like seed storage protein At2g28490 (ARATH)and Growth-regulating factor 1 involved in a variety of functions ranging from storage and gene regulation for disease resistance.DiscussionThe results obtained from this work have significant implications for the in-depth analysis of the genetic structure underlying key traits in yam. Additionally, this study emphasizes the identification of SNP variants and genes that may be utilized for genomic-informed selection in order to enhance yield and disease resistance in yams.
Clinical phenotype, NOD2 genotypes, and treatment observations in Yao syndrome: a retrospective case series
Authors: Williamson Katrina A. , Samec Matthew J. , Patel Jenny A. , Orandi Amir B. , Wang Benjamin , Crowson Cynthia S. , Loftus Edward V. , Alavi Afsaneh , Moyer Ann M. , Davis John M. 
Published: October 2024

ObjectiveThe aim of this study was to characterize the phenotype and genotype of patients with Yao syndrome (YAOS), with focus on comparing to prior cohorts, identifying novel features, and describing treatment observations.MethodsA retrospective medical records review of patients with YAOS seen at Mayo Clinic was conducted to characterize clinical features, NOD2 genotypes, and therapeutic trials and responses.ResultsTwenty-two patients diagnosed with YAOS were included. Eighteen patients (81.8%) were female and twenty (90.9%) were White. Mean age at symptom onset was 24.0 ± 14.8 years. Common clinical manifestations included fever (81.8% of patients), rash (95.5%), chronic gastrointestinal symptoms (100%), arthralgia/arthritis (95.5%), and sicca symptoms (68.2%). NOD2 genotypes as single variants included IVS8 + 158 in 14 patients (63.6%), R702W in 8 patients (36.4%), 1007fs in 4 (18.2%), and one patient had only a previously unreported rare variant. Eight patients (36.4%) had compound (two or more) NOD2 variants. Potential comorbidities of YAOS observed in this cohort included gastrointestinal dysmotility, autonomic dysfunction, and mast cell activation-like symptoms. Glucocorticoid responsiveness was observed in 15 of 20 patients exposed (75%). Eleven patients (50.0%) received IL-1 inhibitor therapy, and one patient (4.5%) received IL-6 inhibitor therapy with adequate disease control.ConclusionOur findings substantiate the occurrence of fevers, arthralgia/arthritis, rash, chronic gastrointestinal symptoms, and sicca-like symptoms described previously in patients with YAOS. Novel clinical features and one NOD2 variant not previously described were identified. Glucocorticoids, biologic IL-1 inhibitors, and IL-6 receptor inhibitors appeared to be effective for treatment of patients with YAOS.
A comparison of haploidentical versus HLA-identical sibling outpatient hematopoietic cell transplantation using reduced intensity conditioning in patients with acute leukemia
Authors: Jaime-Pérez José Carlos , Valdespino-Valdes Jorge , Gómez-De León Andrés , Barragán-Longoria Renata Valeria , Dominguez-Villanueva Adriana , Cantú-Rodríguez Olga Graciela , Gutiérrez-Aguirre César Homero , Gómez-Almaguer David 
Published: October 2024

BackgroundHematopoietic cell transplantation (HCT) increases survival for acute leukemia. Outpatient allogeneic HCT reduces costs and increases transplant rates in developing countries. We report outcomes of outpatient HLA-identical and haploidentical HCT in acute leukemia.MethodsThis single-center retrospective cohort study analyzed 121 adult patients with acute myeloblastic (AML) and acute lymphoblastic leukemia (ALL) receiving an outpatient allogeneic HCT with peripheral blood allografts after reduced-intensity conditioning (RIC) from 2012-2022.ResultsThere were 81 (67%) haploidentical and 40 (33%) HLA-identical transplants. Complete chimerism (CC) at day +100 was not different in HLA-identical compared to haploidentical HCT (32.5% and 38.2%, P=0.054). Post-HCT complications, including neutropenic fever (59.3% vs. 40%), acute graft-versus-host-disease (aGVHD) (46.9% vs. 25%), cytokine release syndrome (CRS) (18.5% vs. 2.5%), and hospitalization (71.6% vs 42.5%) were significantly more frequent in haploidentical HCT. Two-year overall survival (OS) was 60.6% vs. 46.9%, (P=0.464) for HLA-identical and haplo-HCT, respectively. There was no difference in the 2-year disease-free-survival (DFS) (33.3% vs. 35%, P=0.924) between transplant types. In multivariate analysis, positive measurable residual disease (MRD) at 30 days (HR 8.8, P=0.018) and 100 days (HR 28.5, P=0.022) was associated with lower OS, but not with non-relapse mortality (NRM) (P=0.252 and P=0.123, univariate). In univariate analysis, both 30-day and 100-day MRD were associated with lower DFS rates (P=0.026 and P=0.006), but only day 30 MRD was significant in multivariate analysis (P=0.050). In the case of relapse, only MRD at day 100 was associated with increased risk in the univariate and multivariate analyses (HR 4.48, P=0.003 and HR 4.67, P=0.008). Chronic graft-versus-host-disease (cGVHD) was protective for NRM (HR 0.38, P=0.015). There was no difference in cumulative incidence of relapse (CIR) between transplant types (P=0.126). Forty-four (36.4%) patients died, with no difference between HCT type (P=0.307). Septic shock was the most frequent cause of death with 17 cases, with no difference between transplant typesConclusionsOutpatient peripheral blood allogenic HCT after RIC is a valid and effective alternative for adult patients suffering acute myeloblastic or lymphoblastic leukemia in low-income populations.
Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda
Authors: Ssekamatte Phillip , Nabatanzi Rose , Sitenda Diana , Nakibuule Marjorie , Bagaya Bernard Ssentalo , Kibirige Davis , Kyazze Andrew Peter , Kateete David Patrick , Sande Obondo James , Crevel Reinout van , Cose Stephen , Biraro Irene Andia 
Published: October 2024

BackgroundEfforts to eradicate tuberculosis (TB) are threatened by diabetes mellitus (DM), which confers a 3-fold increase in the risk of TB disease. The changes in the memory phenotypes and functional profiles of Mycobacterium tuberculosis (Mtb)-specific T cells in latent TB infection (LTBI)-DM participants remain poorly characterised. We, therefore, assessed the effect of DM on T-cell phenotype and function in LTBI and DM clinical groups.MethodsWe compared the memory phenotypes and function profiles of Mtb-specific CD4+ and CD8+ T cells among participants with LTBI-DM (n=21), LTBI-only (n=17) and DM-only (n=16). Peripheral blood mononuclear cells (PBMCs) were stimulated with early secretory antigenic 6 kDa (ESAT-6) and culture filtrate protein 10 (CFP-10) peptide pools or phytohemagglutinin (PHA). The memory phenotypes (CCR7/CD45RA), and functional profiles (HLA-DR, PD-1, CD107a, IFN-γ, IL-2, TNF, IL-13, IL-17A) of Mtb-specific CD4+ and CD8+ T cells were characterised by flow cytometry.ResultsNaïve CD4+ T cells were significantly decreased in the LTBI-DM compared to the LTBI-only participants [0.47 (0.34-0.69) vs 0.91 (0.59-1.05); (p&lt;0.001)]. Similarly, CD8+ HLA-DR expression was significantly decreased in LTBI-DM compared to LTBI-only participants [0.26 (0.19-0.33) vs 0.52 (0.40-0.64); (p&lt;0.0001)], whereas CD4+ and CD8+ PD-1 expression was significantly upregulated in the LTBI-DM compared to the LTBI-only participants [0.61 (0.53-0.77) vs 0.19 (0.10-0.28); (p&lt;0.0001) and 0.41 (0.37-0.56) vs 0.29 (0.17-0.42); (p=0.007)] respectively. CD4+ and CD8+ IFN-γ production was significantly decreased in the LTBI-DM compared to the LTBI-only participants [0.28 (0.19-0.38) vs 0.39 (0.25-0.53); (p=0.030) and 0.36 (0.27-0.49) vs 0.55 (0.41-0.88); (p=0.016)] respectively. CD4+ TNF and CD8+ IL-17A production were significantly decreased in participants with LTBI-DM compared to those with LTBI-only [0.38 (0.33-0.50) vs 0.62 (0.46-0.87); (p=0.004) and 0.29 (0.16-0.42) vs 0.47 (0.29-0.52); (0.017)] respectively. LTBI-DM participants had significantly lower dual-functional (IFN-γ+IL-2+ and IL-2+TNF+) and mono-functional (IFN-γ+ and TNF+) CD4+ responses than LTBI-only participants. LTBI-DM participants had significantly decreased dual-functional (IFN-γ+IL-2+, IFN-γ+ TNF+ and IL-2+TNF+) and mono-functional (IFN-γ+, IL-2+ and TNF+) central and effector memory CD4+ responses compared to LTBI-only participants.ConclusionType 2 DM impairs the memory phenotypes and functional profiles of Mtb-specific CD4+ and CD8+ T cells, potentially indicating underlying immunopathology towards increased active TB disease risk.