bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a predictive model for assessing the risk of follicular carcinoma in thyroid nodules identified as suspicious by intraoperative frozen section
Authors: Li Cheng , Luo Yong , Gan Yongli , Jiang Yan , Li Qi , Huang Jin 
Published: September 2024

IntroductionFollicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and is characterized by a higher risk of distant metastasis compared to papillary thyroid cancer. Intraoperative frozen section (IOFS) diagnosis of FTC is challenging due to its limited sensitivity and accuracy, leading to uncertainty in intraoperative surgical decision-making. In response, we developed a predictive model to assess the risk of follicular carcinoma in thyroid nodules identified as suspicious for follicular neoplasm by IOFS.MethodsThis model was derived from preoperative clinical and ultrasound data of 493 patients who underwent thyroid surgery at Ningbo Medical Center Lihuili Hospital. It identified five significant predictors of follicular carcinoma: nodule size, thyroglobulin (Tg) level, hypoechogenicity, lobulated or irregular margins, and thick halo.ResultsThe model demonstrated robust discrimination and calibration, with an area under the curve (AUC) of 0.83 (95% CI: 0.77-0.90) in the training set and 0.78 (95% CI: 0.68-0.88) in the validation set. In addition, it achieved a sensitivity of 81.63% (95% CI: 69.39-91.84) and 68.00% (95% CI: 48.00--4.00), a specificity of 77.42% (95% CI: 72.18-82.66) and 72.51% (95% CI: 65.50-78.96), an accuracy of 78.1% (95% CI: 73.4-82.4) and 71.9% (95% CI: 65.3-78.6), a positive predictive value (PPV) of 41. 67% (95% CI: 35.65-48.84) and 26.79% (95% CI: 19.40-34.33), respectively, and a negative predictive value (NPV) of 95.61% (95% CI: 92.86-97.99) and 94.07% (95% CI: 90.44-97.08) in the training and validation sets, respectively.ConclusionThe model can accurately rule out FTC in low-risk nodules, thereby providing surgeons with a practical tool to determine the necessary extent of surgical intervention for nodules flagged as suspicious by IOFS.
Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota
Authors: Su Shan , Liu Ting , Zheng Jia-Yi , Wu Hai-Cui , Keng Vincent W. , Zhang Shi-Jie , Li Xiao-Xiao 
Published: September 2024

IntroductionUlcerative colitis, a subtype of chronic inflammatory bowel disease (IBD), is characterized by relapsing colonic inflammation and ulcers. The traditional Chinese herbal formulation Huang Lian Jie Du (HLJD) decoction is used clinically to treat diarrhea and colitis. However, the mechanisms associated with the effects of treatment remain unclear. This study aims to elucidate the molecular mechanistic effects of HLJD formulation on colitis.MethodsChronic colitis in mice was induced by adding 1% dextran sulfate sodium (DSS) to their drinking water continuously for 8 weeks, and HLJD decoction at the doses of 2 and 4 g/kg was administered orally to mice daily from the second week until experimental endpoint. Stool consistency scores, blood stool scores, and body weights were recorded weekly. Disease activity index (DAI) was determined before necropsy, where colon tissues were collected for biochemical analyses. In addition, the fecal microbiome of treated mice was characterized using 16S rRNA amplicon sequencing.ResultsHLJD decoction at doses of 2 and 4 g/kg relieved DSS-induced chronic colitis in mice by suppressing inflammation through compromised macrophage activity in colonic tissues associated with the colony-stimulating factor 1 receptor (Csf1r)/Src pathway. Furthermore, the HLJD formula could modify the gut microbiota profile by decreasing the abundance of Bacteroides, Odoribacter, Clostridium_sensu_stricto_1, and Parasutterella. In addition, close correlations between DAI, colon length, spleen weight, and gut microbiota were identified.DiscussionOur findings revealed that the HLJD formula attenuated DSS-induced chronic colitis by reducing inflammation via Csf1r/Src-mediated macrophage infiltration, as well as modulating the gut microbiota profile.
Causal effect of thyroid cancer on secondary primary malignancies: findings from the UK Biobank and FinnGen cohorts
Authors: Wang Zhengshi , Rixiati Youlutuziayi , Jia Chengyou , Xu Yong , Yin Zhiqiang , Huang Junwen , Dai Jiaqi , Zhang Yun 
Published: September 2024

BackgroundExisting epidemiological data indicated a correlation between thyroid cancer (THCA) and the risk of secondary primary malignancies (SPMs). However, the correlation does not always imply causality.MethodsThe Mendelian randomization (MR) analyses were performed to investigate the causal relationships between THCA and SPMs based on international multicenter data. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. The Cancer Genome Atlas (TCGA) was used to explore potential mechanisms shared by THCA and bladder cancer (BLCA).ResultsSummary datasets of genome-wide association studies (GWAS) on 30 types of cancers were obtained from the United Kingdom Biobank (UKB) and FinnGen database. Meta-analysis of the UKB and FinnGen results revealed that THCA was significantly positively correlated with BLCA (OR = 1.140; 95% CI, 1.072-1.212; P &lt; 0.001). Four genes, including WNT3, FAM171A2, MLLT11, and ULBP1, were identified as key genes shared by both TCHA and BLCA. Correlation analysis indicated that THCA may increase the risk of secondary BLCA through augmentation of N2 neutrophil infiltration.ConclusionsThis study showed that THCA was causally related to BLCA. It is recommended to conduct more rigorous screenings for BLCA during the follow-up of THCA patients.
CT-guided joint cavity release for postpartum sacroiliac joint pain management: an evaluation of its efficacy, safety, and clinical outcomes
Authors: Mao-jiang Yang , Xian Qiong , Bhetuwal Anup , Bing Li , Xiao-xue Xu 
Published: September 2024

ObjectiveThe central aim of this study was to evaluate the safety and effectiveness of Computed Tomography (CT)-guided joint cavity release in treating patients suffering from postpartum sacroiliac joint pain.MethodsA retrospective analysis was conducted on a sample of 37 patients who presented with postpartum sacroiliac joint pain and underwent CT-guided sacroiliac joint release treatment at The Affiliated Hospital of North Sichuan Medical College. General clinical attributes of the patients were recorded, and the intensity of their pain before and after the operation was compared using the Numeric Pain Rating Scale (NRS). The effectiveness of the surgical treatment was assessed using the Modified MacNab criteria. The functional status of the sacroiliac joint at 3-and 6-month intervals post-operation was examined, and any complications related to surgery were documented.ResultsThe follow-up period was completed by all patients, with the successful implementation of CT-guided unilateral/bilateral sacroiliac joint release undertaken in 37 patients. Patient reported pain, as measured by the Numeric Pain Rating Scale (NRS), was considerably reduced postoperatively with scores showing significant decrement from 7.14 ± 1.23 preoperatively to 1.26 ± 0.53 at 1 week, 1.86 ± 0.62 at 1 month, 1.92 ± 0.48 at 3 months, and 1.97 ± 0.61 at 6 months postoperatively, respectively (p &lt; 0.05). The comprehensive record of treatment response rates, interpreted as excellent and good, were consistent, standing at 100% (37/37), followed by 97.30% (35/37) and concluding with 91.89% (33/37). The Oswestry Disability Index (ODI) scores reflecting the patient’s perceived level of disability prior to the surgery, and at 3 and 6 month intervals post-surgery were 45.12 ± 6.01, 18.14 ± 2.23, and 14.25 ± 2.15, respectively, demonstrating a significant improvement in postoperative scores when compared with preoperative scores (p &lt; 0.05). The surgeries conducted were devoid of any complications such as bleeding, infection, cardiovascular or cerebrovascular incidents, or decline in joint functionality in any of the patients.ConclusionEvidently, CT-guided joint cavity release presents as an effective therapeutic approach for the management of postpartum sacroiliac joint pain, enhancing quality of life and preserving patient safety.
Case Report: The first case of successful pregnancy and live birth following laparoscopic resection of adenomyosis under real-time intraoperative ultrasound elastography guidance
Authors: Ota Yoshiaki , Ota Kuniaki , Takahashi Toshifumi , Horikawa Naoki , Kuroda Ryosuke , Okamoto Hana , Tanaka Yu , Kusumoto Tomoyuki , Oda Takashi , Matsuyama Takehiko , Miyake Takahito , Honda Tetsuro , Shimoya Koichiro 
Published: September 2024

ObjectiveAdenomyosis-related infertility is increasingly being diagnosed, and surgical intervention has been suggested to improve fertility. Elastography, a noninvasive ultrasound technique, is promising for diagnosing and guiding the resection of adenomyosis. This report presents the first case of successful delivery after twin pregnancies achieved with IVF following intraoperative elastography-guided laparoscopic adenomyomectomy.Case reportA 35-year-old Japanese woman with uterine adenomyosis received a gonadotropin analog before surgery. Preoperative MRI revealed a 5.0 × 7.0 cm adenomyoma, leading to scheduled laparoscopic adenomyomectomy with intraoperative elastography. During surgery, elastography ensured the complete resection of the adenomyotic tissue while preserving the endometrium. Postoperative MRI confirmed the absence of residual adenomyosis. The patient underwent in vitro fertilization and embryo transfer, leading to a successful twin pregnancy after double blastocyst transfer. Despite a stable perinatal course, she required hospitalization to prevent preterm labor. At 32 weeks, an elective cesarean section delivered healthy twins. The intra- and post-operation was uncomplicated, and the patient and infants had an optimal health.ConclusionThis is the first reported case of a twin pregnancy resulting from vitrified-warmed embryo transfer after elastography-guided laparoscopic adenomyomectomy, culminating in a successful delivery via cesarean section. This technique allows precise resection and mitigates the risks of uterine rupture and placenta accreta spectrum disorders. Although promising, further studies are required to validate the safety and efficacy of this innovative surgical approach.
The effect of brain-computer interface controlled functional electrical stimulation training on rehabilitation of upper limb after stroke: a systematic review and meta-analysis
Authors: Ren Chunlin , Li Xinmin , Gao Qian , Pan Mengyang , Wang Jing , Yang Fangjie , Duan Zhenfei , Guo Pengxue , Zhang Yasu 
Published: September 2024

IntroductionSeveral clinical studies have demonstrated that brain-computer interfaces (BCIs) controlled functional electrical stimulation (FES) facilitate neurological recovery in patients with stroke. This review aims to evaluate the effectiveness of BCI-FES training on upper limb functional recovery in stroke patients.MethodsPubMed, Embase, Cochrane Library, Science Direct and Web of Science were systematically searched from inception to October 2023. Randomized controlled trials (RCTs) employing BCI-FES training were included. The methodological quality of the RCTs was assessed using the PEDro scale. Meta-analysis was conducted using RevMan 5.4.1 and STATA 18.ResultsThe meta-analysis comprised 290 patients from 10 RCTs. Results showed a moderate effect size in upper limb function recovery through BCI-FES training (SMD = 0.50, 95% CI: 0.26–0.73, I2 = 0%, p &lt; 0.0001). Subgroup analysis revealed that BCI-FES training significantly enhanced upper limb motor function in BCI-FES vs. FES group (SMD = 0.37, 95% CI: 0.00–0.74, I2 = 21%, p = 0.05), and the BCI-FES + CR vs. CR group (SMD = 0.61, 95% CI: 0.28–0.95, I2 = 0%, p = 0.0003). Moreover, BCI-FES training demonstrated effectiveness in both subacute (SMD = 0.56, 95% CI: 0.25–0.87, I2 = 0%, p = 0.0004) and chronic groups (SMD = 0.42, 95% CI: 0.05–0.78, I2 = 45%, p = 0.02). Subgroup analysis showed that both adjusting (SMD = 0.55, 95% CI: 0.24–0.87, I2 = 0%, p = 0.0006) and fixing (SMD = 0.43, 95% CI: 0.07–0.78, I2 = 46%, p = 0.02). BCI thresholds before training significantly improved motor function in stroke patients. Both motor imagery (MI) (SMD = 0.41 95% CI: 0.12–0.71, I2 = 13%, p = 0.006) and action observation (AO) (SMD = 0.73, 95% CI: 0.26–1.20, I2 = 0%, p = 0.002) as mental tasks significantly improved upper limb function in stroke patients.DiscussionBCI-FES has significant immediate effects on upper limb function in subacute and chronic stroke patients, but evidence for its long-term impact remains limited. Using AO as the mental task may be a more effective BCI-FES training strategy.Systematic review registrationIdentifier: CRD42023485744, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023485744.
The impact of statin use on short-term and long-term mortality in patients with heart failure
Authors: Zheng Xiaoxue , Tan Long , Zhang Yu 
Published: September 2024

BackgroundHeart failure (HF) is a complex disorder that has an association with increased morbidity and mortality rates globally. The association of statin use with mortality rate in individuals with HF remains unclear.ObjectivesTo examine the association of statin use with the short-term and long-term all-cause mortality rate in critically ill individuals with HF.MethodsWe performed a retrospective cohort analysis based on the Medical Information Mart for Intensive Care (MIMIC)-IV database. The critically ill people with HF were assigned to a statin group and a non-statin group according to whether they had been treated with statin or not during hospitalization. The Kaplan−Meier (KM) method and Cox proportional hazard models were adopted to explore the link between statin administration and the 30-day, 90-day, as well as 1-year mortality rates. To ensure the robustness of the findings, a 1:1 nearest propensity-score matching (PSM) was also performed.ResultsThe current research included 11,381 patients for the final analysis, with 7,561 in the statin group and 3,820 in the non-statin group. After multiple confounders were adjusted, we found that the Cox regression models revealed great beneficial effects of statin therapy on the 30-day, 90-day, as well as 1-year mortality rates among critically ill individuals with HF in the fully adjusted model. PSM also achieved consistent results. After PSM, the risk of mortality reduced by 23% for the 30-day mortality (HR = 0.77, 95%CI: 0.68–0.88, p &lt; 0.001), 16% for the 90-day mortality rate (HR = 0.84, 95%CI: 0.75–0.93, p &lt; 0.001), and 12% for the 1-year mortality rate (HR = 0.88, 95%CI: 0.81–0.97, p = 0.007). Patients treated with rosuvastatin had the greatest reduction in mortality rate. The 30-day, 90-day, and 1-year all-cause mortality rates were remarkably lower in patients who were treated with low-dose statins.ConclusionOur study unveiled that statin use was related to decreased short-term and long-term all-cause mortality rates in critically ill individuals with HF. Rosuvastatin was associated with the greatest reduction of all-cause mortality rates. Low-dose statins can significantly reduce short-term and long-term mortality, while high-dose statins are not significantly correlated with mortality. However, the results are not conclusive and should be interpreted with caution.
Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration
Authors: Gooding Sarah Warren , Felth Lindsey , Foxall Randi , Rosa Zachary , Ireton Kyle , Sall Izabella , Gipoor Joshua , Gaur Anirudh , King Madeline , Dirks Noah , Whistler Cheryl Allyne , Whistler Jennifer Lynne 
Published: September 2024

IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor. Opioid use is limited by side effects, including significant risk of opioid use disorder. Improvement of the effect/side effect profile of opioid medications is a key pursuit of opioid research, yet there is no consensus on how to achieve this goal. One hypothesis is that the degree of arrestin-3 recruitment to the µ-opioid receptor impacts therapeutic utility. However, it is not clear whether increased or decreased interaction of the µ-opioid receptor with arrestin-3 would reduce compulsive drug-seeking.MethodsWe utilized three genotypes of mice with varying abilities to recruit arrestin-3 to the µ-opioid receptor in response to morphine in a novel longitudinal operant self-administration model. We also created a quantitative method to define compulsivity in drug-seeking based on a multi-variate analysis of several operant response variables.ResultsWe demonstrate that arrestin-3 knockout and wild type mice have highly variable drug-seeking behavior with few genotype differences. In contrast, in mice where the µ-opioid receptor strongly recruits arrestin-3, drug-seeking behavior is much less varied. We found that mice lacking arrestin-3 were more likely to meet the criteria for compulsivity whereas mice with enhanced arrestin-3 recruitment did not develop a compulsive phenotype.ConclusionThese experiments show that a lack of arrestin-3 is not protective against the abuse liability of morphine in an operant self-administration context. Our data also suggest that opioids that engage both G protein and arrestin-3, recapitulating the endogenous signaling pattern, will reduce abuse liability.
Unveiling the potential applications of buds of Lonicera japonica Thunb. var. chinensis (Wats.) Bak based on in vitro biological activities, bio-active components, and potential applications coupled to targeted metabolomics
Authors: Liu Zhenying , Cheng Yunxia , Xiang Yaoting , Chao Zhimao 
Published: September 2024

IntroductionThe buds of Lonicera japonica Thunb. var. chinensis (Wats.) Bak, commonly named red honeysuckle, have attracted attention because of their bright colors. However, owing to the lack of systematic studies, the potential applications of red honeysuckle are not clear, and its development and utilization have not been well known.MethodsIn this study, compared with the buds of L. japonica Thunb. (honeysuckle), the potential applications of red honeysuckle were explored based on biological activities, bio-active components, and sensory flavor combined with widely targeted metabolomics.ResultsAs a result, in vitro tests showed that it had a stronger antioxidant and a stronger inhibitory effect on the growth of Escherichia coli and Staphylococcus aureus. There was no cytotoxicity on LPS-induced RAW264.7 cells in its aqueous extract using the CCK-8 method. Moreover, it also had a stronger effect on inhibiting the expression of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). The content of its bio-active components chlorogenic acid and cynaroside was significantly higher (p ≤ 0.001) than that of green honeysuckle. Widely targeted metabolomics analysis revealed that 4 volatile metabolites, such as (E)-4-hexene-1-ol and pyrazole, and 21 non-volatile metabolites, such as macranthoside B and oleanolic acid-3-O-glc(1-2)-(ara)-28-O-glucoside ester, were specific in red honeysuckle. Interestingly, 14 specific terpenoid metabolites were triterpenoid saponins, indicating a stronger biological activity in red honeysuckle. The sensory flavor analysis showed that the red honeysuckle had a stronger herbal and lighter floral flavor.DiscussionIn conclusion, red honeysuckle had great development value with potential applications in medicines, foods, beverages, pigment additives, and health products.
Psychological resilience and intention to stay among nurses: the mediating role of perceived organizational support
Authors: Pu Jiangfeng , Wang Waner , Li Gege , Xie Zhanghao , Fan Xuanhao , Zhan Ningjing , Xu Yixuan , Huang Huigen 
Published: September 2024

BackgroundThis study aims to analyze the relationship between psychological resilience, perceived organizational support, and intention to stay among nurses. Additionally, it explores the mediating role of perceived organizational support in the relationship between psychological resilience and nurses’ intention to stay.MethodsA cross-sectional survey was conducted between August and September 2023, involving 1,402 nurses from five Grade 3A hospitals in Guangdong. The survey utilized several instruments, including the General Information Questionnaire (GIQ), the Chinese version of the Connor-Davidson Resilience Scale (CD-RISC), the Chinese version of the Perceived Organizational Support Scale (POSS), and the Chinese version of the Intention to Stay Scale (ITSS). The obtained data were analyzed using descriptive statistics and Pearson’s correlation coefficient, while the mediating effect of perceived organizational support was assessed using the PROCESS macro mediation model in SPSS.ResultsThe overall mean score for psychological resilience among nurses in the five Grade 3A hospitals in Guangdong was 60.54 ± 19.17, the overall mean score for perceived organizational support was 45.77 ± 11.49, and the mean score for intention to stay was 20.82 ± 4.65. The results of the statistical analysis revealed positive correlations between psychological resilience and intention to stay (r = 0.388, p &lt; 0.01), between perceived organizational support and psychological resilience (r = 0.570, p &lt; 0.01), and between perceived organizational support and intention to stay (r = 0.550, p &lt; 0.01). Additionally, perceived organizational support was found to mediate the relationship between psychological resilience and intention to stay, with a mediation effect value of 0.067, accounting for 71.28% of the total effect.ConclusionPsychological resilience of nursing staff directly impacts their intention to stay and indirectly influences their caring behaviors, with perceived organizational support serving as a key mediator in both relationships. Therefore, nursing managers should implement targeted interventions to enhance nurses’ psychological resilience and perceived organizational support. Strengthening these factors can significantly increase nurses’ intention to stay in their jobs, improve the quality of care, and contribute to building a strong and stable nursing workforce.
Ketogenic diets in clinical psychology: examining the evidence and implications for practice
Authors: Laurent Nicole , Bellamy Erin L. , Hristova Donika , Houston Ally 
Published: September 2024

IntroductionThe application of ketogenic dietary interventions to mental health treatments is increasingly acknowledged within medical and psychiatric fields, yet its exploration in clinical psychology remains limited. This article discusses the potential implications of ketogenic diets, traditionally utilized for neurological disorders, within broader mental health practices.MethodsThis article presents a perspective based on existing ketogenic diet research on historical use, biological mechanisms, and therapeutic benefits. It examines the potential application of these diets in mental health treatment and their relevance to clinical psychology research and practice.ResultsThe review informs psychologists of the therapeutic benefits of ketogenic diets and introduces to the psychology literature the underlying biological mechanisms involved, such as modulation of neurotransmitters, reduction of inflammation, and stabilization of brain energy metabolism, demonstrating their potential relevance to biopsychosocial practice in clinical psychology.ConclusionBy considering metabolic therapies, clinical psychologists can broaden their scope of biopsychosocial clinical psychology practice. This integration provides a care model that incorporates knowledge of the ketogenic diet as a treatment option in psychiatric care. The article emphasizes the need for further research and training for clinical psychologists to support the effective implementation of this metabolic psychiatry intervention.