bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survey Defining Lip Health—Dermatology and Health Care Providers' Perspectives
Authors: Dulai Ajay S. , Ahmad Nabeel , Afzal Nasima , Sivamani Venita A. , Gunt Hemali B. , Egli Caitlin , Sivamani Raja K. 
Published: October 2024

ABSTRACTBackgroundThere currently exists no consensus on objective features which are relevant in the assessment of overall lip health.AimsThis study seeks to identify features and factors that are associated with healthy lips. This survey will ultimately enable clinicians to objectively track lip health for clinical evaluations and clinical research.MethodsAn anonymous survey was conducted among allied healthcare professionals in‐person and through email. The survey contained questions designed to assess the importance of features of lip health using a 5‐point Likert scale. Features included lack of lip dryness; even tone or lack of hyperpigmentation; lip smoothness; lip color; lip shine, radiance, or luster; definition of the vermillion border/defined lip contour; lip fullness or plumpness; lack of lip lines; and lip firmness. The final questions prompted respondents to select the top three most important features when assessing lip health and to provide any additional pertinent factors.ResultsA total of 334 responses were received, including board‐certified dermatologists (35.9%), dermatology residents (14.7%), and other healthcare specialties (49.4%). The features most cited were lack of lip dryness (65.8%), lip smoothness (38.4%), even tone or lack of hyperpigmentation (38.1%), definition of the vermillion border/defined lip contour (28.0%). Survey results reveal that lip dryness, lip smoothness, lack of hyperpigmentation, and definition of the vermillion border/defined lip contour were the features most associated with lip health.ConclusionThe results from this survey will provide a basis for future research in the field of lip health, research, and clinical treatment.
Hospitalisation cost for paediatric osteomyelitis and septic arthritis in New Zealand
Authors: Hunter Sarah , Alexander Zanazir , Crawford Haemish , Te Ao Braden , Selak Vanessa , Mutu‐Grigg John , Lorgelly Paula , Grant Cameron 
Published: October 2024

AimHospitalisation rates for paediatric bone and joint infection (BJI) in New Zealand (NZ) are among the highest globally. This study aims to quantify hospitalisation costs of BJI in 2018–2019.MethodsNational hospitalisation data from the NZ Ministry of Health was used to describe costs associated with all paediatric hospitalisations coded for osteomyelitis or septic arthritis in those aged <16 years. Data included age, ethnic group, area level deprivation, diagnosis‐related‐group coding, admission length and cost‐weight. Readmissions up to 24 months following the initial encounter were analysed for associated costs.ResultsMore than ten million dollars was spent on hospitalisation for paediatric BJI over the study period (NZ$10 819 474). There were 869 primary hospitalisations and 229 related readmissions. Median length of stay was 7.4 days (95% confidence interval 6.8–7.9). Re‐admission costs were NZ$1 196 640 within 24 months following diagnosis.Higher median hospitalisation costs occurred for children residing in the most deprived versus least deprived neighbourhoods (NZ$12 126 vs. NZ$9010, P < 0.01). NZ Māori compared with non‐Māori children had longer length of stay (8.4 vs. 6.3 days, P = 0.04), more complex and severe illnesses (53% vs. 17%, P < 0.01), and higher median hospitalisation costs (NZ$11 796 vs. NZ$9581, P = 0.03).ConclusionsDirect BJI hospitalisation costs in 2018–2019 were NZ$10 819 474 with 11% of costs due to re‐admission. Direct hospitalisation costs for paediatric BJI in NZ vary by deprivation and ethnic group. Illness complexity of paediatric BJI varies by ethnic group. Interventions are needed to reduce incidence and severity of these debilitating infections.
Antioxidant Capacity of Thyme (Thymus vulgaris) Essential Oil and Its Effect on In Vivo Fertility of Rams Subjected to Testicle Heat Stress
Authors: Khnissi Samia , Ben Salem Imène , Bejaoui Bochra , Fattouch Sami , Mustapha Souha ben , Haj‐Kacem Rami , M'Hamdi Naceur , Martin Patrick , Dattena Maria , Lassoued Narjess 
Published: October 2024

ABSTRACTThe detrimental effects of hyperthermia on the testes and the protective effect of thyme essential oil against testicular damage induced by this stress in rams were studied. Twenty‐four rams of the Barbarine breed with an average weight of 62.5 ± 0.3 kg and an average age of 24 ± 0.6 months. The experiment consisted of inducing localized heat stress on the first group of rams by applying heat bags to both testicles of six rams (G s). The second group underwent the same heat stress on the testes but received orally 100 µL/day/animal of thyme essential oil (G s‐he). A positive control did not undergo stress but received thyme essential oil (G he) with the same doses as the (G s‐he) group, and the negative control did not undergo either stress or receive the essential oil of thyme (G c). One hundred twenty‐eight adult ewes of the same breed divided into four groups of 32 ewes were used to study the effect of different treatments on the in vivo ram's fertility. Ewes are synchronized and we have applied natural mating with oestrus control, the reproduction balance sheet is calculated after lambing. The results showed that tests of heat stress (HS) negatively affect semen quality but did not cause infertility. However, neither tests for heat stress nor treatment with thyme EO significantly affected the haematological profile. The study of the effect of heat stress on the testes on fertility in vivo showed a drop in the number of females who were fertilized at the first oestrus and consequently a drop in fertility. However, the rams that suffered the same stress but were treated with EO thymus recorded an improvement in these parameters.
The influence of different extraction indications on the morphological changes in the maxillary sinus: A retrospective cohort study
Authors: Wang Meng , Mao Fei‐Fei , Jin Xiao‐Hui , Huang Jia‐Ping , Dai Anna , Ding Pei‐Hui 
Published: October 2024

AbstractAimsThe comprehensive effects of maxillary posterior tooth extraction on the maxillary sinus (MS) morphology remain to be thoroughly elucidated. This retrospective cohort study aimed at evaluating the influence of different extraction indications on the morphological changes in the MS by utilizing cone‐beam computed tomography (CBCT).MethodsOne hundred and seventy‐eight of maxillary posterior tooth extractions underwent CBCT scans before and after extraction using 3D Slicer software. Parameters such as maxillary sinus pneumatization (MSP, the primary outcome measure), buccal bone height (BBH), palatal bone height (PBH), mucosal thickness (MT), and other anatomical structures were measured for patients undergoing extraction due to periodontitis, periapical lesions, or tooth fracture. Multiple linear regression analysis was employed to assess the effect of extraction indications on the MS.ResultsWhile the primary outcome, MSP, did not reveal statistically significant differences across various indications for tooth extraction (p > .05), extraction itself resulted in MSP (p < .05). The rate of this pneumatization was influenced by the position of the extraction site (p < .05). Additionally, baseline values of bone height and mucosal thickness showed an inverse correlation with the rate of change in these parameters following tooth extraction (p < .001).ConclusionsTooth extraction led to increased pneumatization of the maxillary sinus while simultaneously reducing bone height and mucosal thickness. However, these outcomes were not influenced by the reason for tooth extraction.
Metabolomic fingerprinting of milk fever cows: Pre‐ and postpartum metabolite alterations
Authors: Zwierzchowski Grzegorz , Zhang Guanshi , Tobolski Dawid , Wójcik Roman , Wishart David S. , Ametaj Burim N. 
Published: October 2024

AbstractBackgroundMilk fever (MF), a metabolic disorder in dairy cows characterized by low blood calcium concentrations postpartum, is well‐recognized clinically. However, comprehensive data on the alteration of metabolites associated with this condition remains sparse.HypothesisDelineate serum metabolite profiles and metabolic pathways preceding, coinciding with, and after the onset of MF.AnimalsTwenty‐six cows, including 20 healthy cows and 6 cows initially affected by MF. Because of culling, the number of MF‐affected cows decreased to 4 at MF week, +4 weeks, and +8 weeks postpartum.MethodsA nested case‐control longitudinal study was conducted, with blood samples collected at −8 and −4 weeks prepartum, MF week, and +4 and +8 weeks postpartum. Serum analysis utilized direct injection/liquid chromatography/tandem mass spectrometry (DI/LC/MS/MS) techniques.ResultsKey findings included the identification of diverse metabolites such as hexose, amino acids, phosphatidylcholines, lysophosphatidylcholines, and sphingomyelin, which varied between studied groups (P < .05). The most marked metabolic alterations were observed 4 weeks prepartum. In total, 42, 56, 38, 29, and 24 metabolites distinguished the MF group at the respective time points (P < .05). Additionally, 33 metabolic pathways, including amino acid, antioxidant metabolism, fatty acid degradation, and carbohydrate processing, were impacted (P < .05).Conclusions and Clinical ImportanceMetabolic disruptions in dairy cows begin several weeks before the clinical manifestation of MF and persist up to 8 weeks postpartum. These findings emphasize the complexity of MF, extending beyond only hypocalcemia and indicate the necessity for preemptive monitoring in dairy herd management.
Improvement of gastric disease and ridden horse pain ethogram scores with diet adaptation in sport horses
Authors: Pineau Violaine , ter Woort Fe , Julien Félicie , Vernant Margaux , Lambey Sandrine , Hébert Camille , Hanne‐Poujade Sandrine , Westergren Victor , van Erck‐Westergren Emmanuelle 
Published: October 2024

AbstractBackgroundGastric disease is highly prevalent in sport horses and may lead to poor performance, cause behavioral changes and impact welfare.HypothesisAssess whether diet affects gastric disease and pain expression during riding, and whether it has an impact on physiological and locomotor variables during an exercise test, including jumps.AnimalsNine healthy show‐jumping Warmbloods trained at the same stable.MethodsProspective observational cohort study. The horses receiving a pelleted diet, high in sugar and starch (>30%), were examined at T0 and after 12 weeks (T12) of changing to a cooked, muesli‐type low‐starch (11%) diet. Each time, the horses underwent a standardized exercise test (SET) and a ridden pain score (Ridden Horse Pain Ethogram [RHpE]) was calculated by 2 blinded observers. The next day, horses underwent gastroscopy and gastric lesions were scored blindly. Results were analyzed using Wilcoxon and Spearman tests.ResultsAfter 12 weeks of a low starch diet, the Equine Gastric Disease (EGD; 4 [3–5] at T0 vs 1 [0‐1] at T12, P < .01) and RHpE scores (6 [3–13] at T0 vs 3 [0‐6] at T12, P < .01) improved significantly. Squamous, glandular, and EGD scores were positively correlated with RHpE scores (respectively, r = .747, P < .01; r = .743, P < .01 and r = .867, P < .01).Conclusion and Clinical ImportanceGastric disease and pain scores correlated positively in ridden horses. A low starch diet significantly decreases the severity of gastric disease and associated pain score during riding in horses. Gastric ulcers may be mitigated and the comfort of equines athletes improved by dietary adjustments.
Prevalence and Risk Factors of Tinea Capitis Among Primary School Children in the Grand Lomé Region (Togo), 2021: A Cross‐Sectional and Case–Control Study Approach
Authors: Dorkenoo Ameyo M. , Adjetey‐Toglozombio Akovi K. , Alidou Smaila , Etassoli Justin Santrao , Sossou Efoe , Lack Fiali , Afankoutché Massan J. , Awaté Emmanuel , Améyapoh Yaovi 
Published: October 2024

ABSTRACTBackgroundTinea capitis is an infectious dermatosis frequent in children, causative fungi variable over time and space. The risk factors associated with this disease are still poorly understood. The objective of this study was to estimate the prevalence of tinea capitis among schoolchildren in Lomé (Togo), identify the fungal species involved and assess the associated risk factors.Patients and MethodsIt was a cross‐sectional and case–control study conducted in primary schools in Lomé from November 2020 to April 2021. All pupils presenting tinea capitis suspected lesions have been sampled, and the scraping and hair were examined by direct microscopy in KOH solution and cultured in Sabouraud dextrose agar with chloramphenicol and cycloheximide. Positive children were matched by age and sex with those without symptoms for case–control study.ResultsOut of the 15,087 pupils enrolled, 465 had positive cultures for dermatophytes, corresponding to the tinea capitis prevalence of 3.08% (95% CI [2.59–3.57]). Trichophyton mentagrophytes (81.86%) and Trichophyton soudanense (13.12%) were the majors isolated dermatophytes. The risk factors were mostly living in households with domestic animals, showering less than twice a day, having a history of ringworm, having similar lesions in the same household and sharing personal hygiene items.ConclusionThis study highlights the low prevalence of tinea capitis in schoolchildren in Lomé (Togo), the causative species dominated by T. mentagrophytes and emphasises the importance of environmental and behavioural factors in the mycosis transmission. Implementing preventive measures addressing the identified factors could help to reduce the prevalence of this disease.
Fungal Intracranial Infections (Central Nervous System‐Invasive Fungal Disease) in Patients With Haematological Disorders—A Single‐Centre Retrospective Study
Authors: Chattopadhyay Sohini , Sumanth Lydia Jennifer , Vanjare Harshad Arvind , Lionel Sharon Anbumalar , Selvarajan Sushil , Kulkarni Uday , Abubacker Fouzia N. , Lakshmi Kavitha M. , Korula Anu , Abraham Aby , Mathews Vikram , Michael Joy Sarojini , George Biju 
Published: October 2024

ABSTRACTBackgroundInvasive fungal disease (IFD) is a sinister complication encountered in patients with haematological disorders. When occurring in the central nervous system (CNS), IFDs can have catastrophic outcomes.ObjectivesTo study the clinical presentation, predisposing etiological factors, and prognosis of a CNS‐IFD in a patient with a haematological disorder.Patients and MethodsThis is a retrospective study focusing on the clinical profile, diagnosis, treatment strategy and outcomes of 43 patients with an underlying haematological disorder, who were diagnosed with CNS‐IFD between 2018 and 2022.ResultsOf the 43 patients, 18 were chemotherapy recipients, while 23 were stem cell transplant (SCT) recipients and 2 presented with CNS‐IFD at diagnosis. AML/MDS (37.2%) and ALL (18.6%) were the predominant underlying diagnoses. A sudden deterioration in sensorium (53.5%) was the earliest clinical sign, while T2 hyperintensities (26.8%), vascular involvement (26.8%) and ring‐enhancing lesions (16.3%) were the commonest radiological findings, with all patients exhibiting diffusion restriction in diffusion‐weighted images. Microbiological evidence of infection was obtained in all patients; however, culture positivity was established in only 25 patients. Rhizopus spp (23.2%) and Aspergillus spp (20.9%) were implicated in most cases. Overall survival of the cohort was 27.9% at a median follow‐up of 6 months. In patients who succumbed, the median time to death was 4 days (0–46).ConclusionCNS‐IFD is associated with very poor survival in patients undergoing chemotherapy or an SCT, urging the need for prompt diagnosis and initiation of suitable antifungal therapy.
“Organizing practice”: The hidden work of homecare nurses in fighting health inequity and advancing social justice
Authors: Tind Anitha M. , Hoeck Bente , Andersen Helle Elisabeth , Delmar Charlotte 
Published: October 2024

AbstractThe nursing profession has a long history of advocating for social justice and health equity, and both values profoundly infuse nursing ethics, theory, and education. Homecare nursing occurs between the patient's daily life at home and the public health care system. Therefore, homecare nurses ideally possess insight into the living conditions and social determinants of health that their patients experience. This interpretive phenomenological study explores the strategies employed by homecare nurses to fight health inequity and advance social justice. Data were collected through participant observations, situational interviews, and small group interviews with 12 homecare nurses from two municipalities. Three analytical approaches were used: paradigm cases, exemplars, and thematic analysis. The data identified two primary strategies homecare nurses use to circumvent, solve, and mitigate the negative consequences of social determinants of health on patients' care and treatment: “Negotiating practice” and “Aligning practice.” “Negotiating practice” ensures that care and treatment are delivered in a way acceptable to all involved. “Aligning practice” ensures cohesion, progression in the treatment and care trajectory, and support for patients and relatives in navigating the system. Both strategies are part of nurses' largely hidden work, reflecting the nursing profession's position as nested between the individual patient and the system.
A systematic review and meta‐ethnography exploring personal perspectives of recovery among those with lived experience of non‐suicidal self‐injury
Authors: Hudson Emily , Hemmings Bali , Hartley Samantha , Taylor Peter 
Published: October 2024

AbstractBackgroundNon‐suicidal self‐injury (NSSI) is a significant public health concern. Research and treatment interventions largely focus on stopping self‐injury. People who self‐injure do not necessarily equate recovery to cessation. Qualitative accounts allow greater understanding of personal recovery narratives. This study aimed to synthesise personal conceptualisations of NSSI recovery.MethodsParticipants had lived experience of NSSI and discussed their recovery. Papers not written in English or had a quantitative design were excluded. Four databases (PsycInfo, CINAHL, Medline and Web of Science) were systematically searched. The quality of each paper was assessed using the CASP quality assessment tool. Data were synthesised using a meta‐ethnographic approach.ResultsThirteen studies comprising 159 participants were included. Three overarching themes were developed. While ceasing NSSI was an important aspect of recovery for some, recovery was typically viewed more holistically, encompassing developments within the self and relationships. Recovery was regarded an ongoing non‐linear journey. The personal and multifaceted nature of the recovery process emerged through a line of argument synthesis.ConclusionsThis was the first qualitative synthesis of personal conceptualisations of NSSI recovery. The findings highlighted the personal and multifaceted nature of NSSI recovery and supported person‐centred models of self‐injury recovery. Clinical implications include the importance of expanding self‐injury recovery beyond cessation within research and clinical practice, and for collaborative and person‐centred approaches to be embraced when supporting those who self‐injure.
The Arabidopsis PIP1;1 Aquaporin Represses Lateral Root Development and Nitrate Uptake Under Low Nitrate Availability
Authors: Schley Thayssa Rabelo , Zhu Ting , Geist Birgit , Crabos Amandine , Dietrich Daniela , Alandes Regina A. , Bennett Malcolm , Nacry Philippe , Schäffner Anton R. 
Published: October 2024

ABSTRACTNitrate (NO3−) deficiency decreases root water uptake and root hydraulic conductance. This adaptive response is correlated with reduced abundance and activity of plasma membrane intrinsic protein (PIP) aquaporins. We therefore screened changes in the root architecture of a complete set of Arabidopsis pip loss‐of‐function mutants grown under NO3− deficiency to systematically approach the impact of PIPs under these conditions. NO3− deprivation led to attenuated responses of specific pip single mutants compared to the strongly altered LR parameters of wild‐type plants. In particular, pip1;1 exhibited a lower relative reduction in LR length and LR density, revealing that PIP1;1 represses LR development when NO3− is scarce. Indeed, PIP1;1 compromises root and shoot NO3− accumulation during early developmental stages. A fluorescent VENUS‐PIP1;1 fusion revealed that PIP1;1 is specifically repressed in the pericycle, endodermis and at the flanks of emerging LRs upon NO3− deficiency. Thus, LR plasticity and NO3− uptake are affected by an interactive mechanism involving aquaporins (PIP1;1) and nitrate accumulation during seedling development under NO3−‐deficient conditions.
Hyperspectral Imaging Reveals Differential Carotenoid and Chlorophyll Temporal Dynamics and Spatial Patterns in Scots Pine Under Water Stress
Authors: Miettinen Iiro , Zhang Chao , Alonso Luis , Fernández‐Marín Beatriz , García‐Plazaola José I. , Grebe Steffen , Porcar‐Castell Albert , Atherton Jon 
Published: October 2024

ABSTRACTDrought‐related die‐off events have been observed throughout Europe in Scots pine (Pinus sylvestris L.). Such events are exacerbated by carbon starvation that is, an imbalance of photosynthetic productivity and resource usage. Recent evidence suggests that optically measurable photosynthetic pigments such as chlorophylls and carotenoids respond to water stress (WS). However, there is a lack of measurements using imaging spectroscopy, and the mechanisms linking xanthophyll‐related changes in reflectance captured by the photochemical reflectance index (PRI) and chlorophyll changes in red edge position (REP) to WS are not understood. To probe this, we conducted a greenhouse experiment where 3‐year‐old Pinus sylvestris saplings were subjected to water limitation and followed using hyperspectral imaging (HSI) spectroscopy, water status and photosynthetic measurements. Carotenoids (e.g., xanthophyll cycle) and chlorophylls responded to WS, which was observed using the HSI‐derived indices PRI and REP respectively. The spatial‐temporal response in these two pigment‐reflectance groupings differed. The spatial distribution of PRI represented the light intensity around the time of the measurement, whereas REP reflected the daily averaged light intensity over the experimental course. A further difference was noted upon rewatering, where the carotenoid‐related PRI partially recovered but the chlorophyll‐related REP did not.