bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIMULACRA ASAS PRADUGA TIDAK BERSALAH DALAM INGSUTAN KEWENANGAN PRAPERADILAN
Authors: , Muhammad Rustamaji 
Published: March 2017

Abstract
died. ‘New World’ which Baudrillard calls the ‘Galactic Simulacra’, was struck all life aspects, including law. Dialectics about the pretrial judge over status of a suspect several times ago which is better known as Sarpin’s Effect, and has been abolished with the appearance of The Constitutional Court Decision Number 21 / PUU-XII / 2014, shows how the reality of the presumption of innocence (APTB) often turns
into hyperreality in the application of national law APTB at the pretrial stage, which applies only in textual various issues surrounding the complexity of the legal reality. The competition between the presumption of guilt and innocence, the legal and factual concept in the minds of law enforcement, as well as human values that precede the legality brooded in the Pancasila revolution ala Indonesia human rights, failed to
be described due to the simplifying of Presumption of Innocence in monofacet. Therefore, Presumption of Innocence as one of the principles at the core of the formal criminal law, according to Satjipto Rahardjo, it is proper to be conceived as a law manner that does not just stop at reading the text, but continues with the action or human effort. An effort that certainly draining the mind, empathy and courage, which
is not purely alles binnen de cadre van de wet.

Key Words : Presumption of Innocence, normativity, contextuality, the Indonesian way, pretrial

Abstrak
Jean Baudrillard melalui Simulacra and Simulation (1981) membuat rancangan pikir yang memprediksi bahwa realitas pada akhirnya telah mati. ‘Dunia baru’ yang Baudrillard sebut sebagai ‘Galaksi Simulacra ternyata melanda seluruh aspek kehidupan tidak terkecuali hukum. Dialektika tentang praperadilan yang mengadili status tersangka beberapa waktu lalu yang lebih dikenal sebagai Sarpin’s Effect, dan dipungkasi dengan munculnya Putusan MK Nomor 21/PUU-XII/2014, menunjukkan betapa realitas asas praduga tidak bersalah (APTB) acapkali berubah menjadi hiperealitas dalam penerapan hukum nasional. APTB pada tahap praperadilan yang hanya diterapkan secara tekstual dan dipisahlepaskan dari konteksnya, hukumnya. Persaingan antara praduga bersalah dan tidak bersalah, maupun kesenjangan legal concept dan factual concept dalam benak penegak hukum, serta nilai kemanusiaan yang mendahului legalitas yang diperam dalam revolusi Pancasila ala HAM Indonesia, gagal tergambar akibat penyedehanaan APTB yang monofaset. Oleh karenanya, APTB sebagai salah satu asas yang menjadi inti dalam hukum pidana formil, menurut Satjipto Rahardjo, sudah selayaknya dikonsepsikan sebagai cara berhukum
yang tidak hanya berhenti pada membaca teks, tetapi melanjutkannya dengan aksi atau usaha (effort) manusia. Suatu usaha yang tentu saja menguras energi, baik pikiran maupun empati dan keberanian yang tidak semata-mata bersifat alles binnen de kader van de wet.

Kata kunci: asas praduga tidak bersalah, normativitas, kontekstualitas, keindonesiaan, praperadilan.
Occipitocervical Fusion for Severe Atlantoaxial Dislocation in an Underdeveloped Child with Chondrodysplasia Punctata
Authors: Tanaka Yuki , Watanabe Kei , Katsumi Keiichi , Ohashi Masayuki , Nagasaki Keisuke , Hirano Toru 
Published: February 2017

Case:
We present a case of brachytelephalangic chondrodysplasia punctata with a severe atlantoaxial dislocation in an underdeveloped child. The patient underwent halo jacket application using 10 halo pins with <1 lb/in2 of torque, followed by posterior occipitocervical fusion with onlay rib and iliac autografts. After bone grafts and replacement of the halo ring multiple times, successful osseous fusion had been achieved by the 2-year follow-up.

Conclusion:
Although simple bone-grafting with a halo jacket is useful in underdeveloped patients with skeletal dysplasia, the complications related to halo fixation, including cranial bone perforation, and the patient’s neurological status must be carefully monitored.
Selective Spinal Fusion for Neuromuscular Scoliosis in a Patient with Pompe Disease
Authors: Tanida Atsushi , Tanishima Shinji , Mihara Tokumitsu , Narita Aya , Maegaki Yoshihiro , Nagashima Hideki 
Published: February 2017

Case:
A 16-year-old girl with Pompe disease underwent surgery for scoliosis. She had been able to walk without any assistance, and kept her balance by swinging her waist. Therefore, we performed posterior selective spinal correction and fusion to avoid any adverse effects on walking ability that could occur with immobilization of the lumbosacral spine. After surgery, she was highly satisfied with her ability to perform the activities of daily living.

Conclusion:
For nonambulatory patients with scoliosis and Pompe disease, long fusion from the upper thoracic spine to the pelvis is generally required. However, in ambulatory patients, in order to maintain the ability to walk, selective spinal fusion is an alternative.
Restoration of Humeral Bone Stock Two Years After Internal Fixation of a Periprosthetic Fracture with a Loose Stem
Authors: Fang Christian , Yan Chun-Hoi , Yee Dennis , Lau Tak-Wing , Wong Tak-Man , Leung Frankie 
Published: February 2017

Case:
We describe 2 patients who sustained a periprosthetic humeral fracture with a loosened long-stemmed Coonrad-Morrey total elbow prosthesis. As noted in the literature, the success rate for a major revision with use of strut grafts is around 70%; therefore, both cases were managed without revision of the prosthesis. A submuscular locking plate was placed following typical fracture fixation principles. Screws that interfered with the humeral stem and the distal flange stabilized both the distal fragment and the humeral stem.

Conclusion:
At 2 years postoperatively, both fractures had healed, with increased endosteal bone stock. In each case, the prosthesis was successfully salvaged, and radiographic reconstitution of the implant-bone interface was noted after 2 years.
Arthroscopic Reconstruction After Acute Acromioclavicular Separation Injuries
Authors: Minkus Marvin , Kraus Natascha , Hann Carmen , Scheibel Markus 
Published: February 2017

Acute acromioclavicular (AC)-joint dislocations are common injuries of the shoulder girdle. Surgical repair is indicated for acute high-grade (Rockwood types IV, V, and VI) AC-joint injuries. The best treatment for type III is still controversial, but young and active patients with this type of injury might benefit from a surgical AC-joint stabilization. Surgery should be performed within the first 3 weeks after the injury since the biological healing potential decreases with time. Acute AC-joint separation is diagnosed by clinical examination and radiography. Vertical translation anteroposterior stress views with a 10-kg load are used to grade the injuries. Bilateral lateral stress (Alexander) views are used to evaluate dynamic horizontal translation qualitatively.
Arthroscopic techniques for AC reconstruction have become more popular in recent years because they are minimally invasive; they allow treatment of concomitant glenohumeral lesions; and they can be performed in one step, with insertion of implants that do not have to be removed later. The arthroscopically assisted double-button technique with an additional AC cerclage was developed to stabilize the AC joint by internal bracing of the torn ligaments.
The procedure consists of the following steps. Step 1: With the patient in the beach-chair position, a 2-cm incision is made on top of the clavicle and posterior and lateral viewing portals as well as an anteroinferior working portal are created. Step 2: With the arthroscope in the lateral portal, the subcoracoid bursa and the base of the coracoid are dissected with a radiofrequency ablation device through the anteroinferior portal. Step 3: Coracoclavicular drilling is done with use of a drill guide and under arthroscopic and image-intensifier control. After overdrilling of the Kirschner wires, Nitinol suture passers are introduced and retrieved via the anteroinferior portal. Step 4: Transclavicular and transacromial drill-holes are established for the AC cerclage. Step 5: The 2 double-button devices are attached to the Nitinol suture passers, and the inferior buttons are shuttled through the clavicle and coracoid and then placed parallel to the coracoid base. Step 6: The sutures are tightened, and an anatomical vertical reduction of the AC joint is achieved. Step 7: A triangular acromioclavicular nonabsorbable cerclage tape is used for horizontal stabilization. Step 8: The clavicular incision is closed in 2 layers, including the repair of the deltotrapezoidal fascia and the arthroscopic portals, in a standard fashion.
The combined arthroscopically-assisted and image-intensifier-controlled double-button technique with an additional AC cerclage is a safe procedure that enables an anatomical reduction of the AC joint and yields good to excellent clinical results.
The Aesthetics of a Three-Way Pattern: The Musical Concept of Talempong Renjeang and The Social System of The People of Luhak Nan Tigo Minangkabau
Authors: Sastra Andar Indra 
Published: March 2017

The goal of this article is to discuss the aesthetics of the three-way pattern in the musical concept of talempong renjeang (tenteng) and the social system of the people of Luhak Nan Tigo Minangkabau. The musical concept of talempong renjeang is formed by 3 (three) pairs of talempong: talempong Jantan, talempong Paningkah, and talempong Pangawinan. As the ‘leader’, the talempong Jantan maintains the consistency and integrity of the theme and danyuik (tempo) of the playing, the talempong Paningkah follows the lead of the talempong Jantan using different playing motifs, and the talempong Pangawinan has the role and authority to make the guguah (melody) of the talempong complete – creating a three-way aesthetical pattern. The social system of the people of LuhakNan Tigo was created by three legendary figures, namely Dt. Katumangguangan, Dt. Parpatiah Nan Sabatang, and Dt. Nan Sakelap Dunia (RajoBabandiang). From these three figures, the concept of tali tigo sapilin, tungku nan tigo sajarangan was born (a philosophy of harmony). The method used for the research is based on qualitative data which was collected through observation, interviews, and documentation. The data analysis focuses the talempong renjeang as a musical and the social system of the Minangkabau community which began with two legendary Minangkabau figures. The results of the study show that talempong as a musical system corresponds to, or synchronizes with, the social concept of the people of Luhak Nan Tigo Minangkabau.
Estudos gráficos de artefatos arqueológicos na composição de marcas regionais para projetos de design.
Authors: Luiz de Sousa Richard Perassi 
Published: February 2017

<!--	@page { margin: 2cm }	P { margin-bottom: 0.21cm }	-->	Este artigo interpreta e classifica grafismos contemporâneos desenvolvidos com base em artefatos,	“zoólitos”, encontrados nos sítios arqueológicos (sambaquis) do Estado de Santa Catarina. A Teoria da Forma	e a classificação de grafismos são consideradas na interpretação das representações gráficas. Por suas	características formais e figurativas e por sua relação com a cultura regional, os grafismos são também	apresentados como marcas regionais para serem utilizadas em projetos de Design.
BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis
Authors: Kang SunAh , Fedoriw Yuri , Brenneman Ethan K. , Truong Young K. , Kikly Kristine , Vilen Barbara J. 
Published: February 2017

Abstract
Tissue-specific immune responses play an important role in the pathology of autoimmune diseases. In systemic lupus erythematosus, deposits of IgG-immune complexes and the activation of complement in the kidney have long been thought to promote inflammation and lupus nephritis. However, the events that localize cells in non-lymphoid tertiary organs and sustain tissue-specific immune responses remain undefined. In this manuscript, we show that BAFF promotes events leading to lupus nephritis. Using an inducible model of systemic lupus erythematosus, we found that passive transfer of antinucleosome IgG into AID−/−MRL/lpr mice elevated autoantibody levels and promoted lupus nephritis by inducing BAFF production in the kidneys, and the formation of renal tertiary lymphoid structures (TLSs). Reducing BAFF in vivo prevented the formation of TLSs and lupus nephritis; however, it did not reduce immune cell infiltrates, or the deposits of IgG and complement in the kidney. Mechanistically, lowering BAFF levels also diminished the number of T cells positioned inside the glomeruli and reduced inflammation. Thus, BAFF plays a previously unappreciated role in lupus nephritis by inducing renal TLSs and regulating the position of T cells within the glomeruli.
Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction
Authors: Bouchet Jérôme , del Río-Iñiguez Iratxe , Vázquez-Chávez Elena , Lasserre Rémi , Agüera-González Sonia , Cuche Céline , McCaffrey Mary W. , Di Bartolo Vincenzo , Alcover Andrés 
Published: February 2017

Abstract
The role of endosomes in receptor signal transduction is a long-standing question, which remains largely unanswered. The T cell Ag receptor and various components of its proximal signaling machinery are associated with distinct endosomal compartments, but how endosomal traffic affects T cell signaling remains ill-defined. In this article, we demonstrate in human T cells that the subcellular localization and function of the protein tyrosine kinase Lck depends on the Rab11 effector FIP3 (Rab11 family interacting protein-3). FIP3 overexpression or silencing and its ability to interact with Rab11 modify Lck subcellular localization and its delivery to the immunological synapse. Importantly, FIP3-dependent Lck localization controls early TCR signaling events, such as tyrosine phosphorylation of TCRζ, ZAP70, and LAT and intracellular calcium concentration, as well as IL-2 gene expression. Interestingly, FIP3 controls both steady-state and poststimulation phosphotyrosine and calcium levels. Finally, our findings indicate that FIP3 modulates TCR-CD3 cell surface expression via the regulation of steady-state Lck-mediated TCRζ phosphorylation, which in turn controls TCRζ protein levels. This may influence long-term T cell activation in response to TCR-CD3 stimulation. Therefore, our data underscore the importance of finely regulated endosomal traffic in TCR signal transduction and T cell activation leading to IL-2 production.
Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses
Authors: Martin Praxedis , Palmer Gaby , Rodriguez Emiliana , Seemayer Christian Alexander , Palomo Jennifer , Talabot-Ayer Dominique , Gabay Cem 
Published: February 2017

Abstract
The biological activity of IL-1 is tightly regulated by the specific receptor antagonist (IL-1Ra) and the decoy receptor IL-1 receptor type 2 (IL-1R2). The role of IL-1Ra has been well demonstrated in IL-1Ra–deficient mice. In contrast, the role of endogenous IL-1R2 remains widely unknown. To define the functional role of endogenous IL-1R2 in the K/BxN serum transfer arthritis model and in IL-1β– or LPS-induced systemic inflammation in vivo, IL-1R2−/− mice were created and compared with wild type mice. IL-1R2−/− mice bred habitually and exhibited a normal phenotype. IL-1R2 deficiency aggravated arthritis severity and increased mRNA levels for key cytokines and chemokines such as IL-6, IL-1β, Cxcl-1, and Cxcl-2 significantly in ankles. There was no effect of IL-1R2 deficiency on the cell-autonomous cytokine response to IL-1β in the tested cell types, i.e., neutrophils, macrophages, and fibroblasts, but IL-1R2 deficiency on neutrophils increased the IL-1–induced response of fibroblasts in trans. Furthermore, IL-1β induced shedding of IL-1R2 in vivo. Inflammatory responses to IL-1β and LPS-induced mortality were not different in IL-1R2−/− compared with wild type mice. Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1– and neutrophil-dependent tissue inflammation as shown in the K/BxN serum transfer arthritis model. In contrast to IL-1Ra, IL-1R2 appears to be less crucial for systemic responses to acute administration of IL-1 or LPS.
Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and Gαi2
Authors: Hwang Il-Young , Park Chung , Harrison Kathleen , Kehrl John H. 
Published: February 2017

Abstract
Adaptive immunity depends on mature thymocytes leaving the thymus to enter the bloodstream and the trafficking of T cells through lymphoid organs. Both of these require heterotrimeric Gαi protein signaling, whose intensity and duration are controlled by the regulator of G protein signaling (RGS) proteins. In this study, we show that RGS protein/Gαi2 interactions are essential for normal thymocyte egress, T cell trafficking, and homeostasis. Mature thymocytes with a Gαi2 mutation that disables RGS protein binding accumulated in the perivascular channels of thymic corticomedullary venules. Severe reductions in peripheral naive CD4+ T cells and regulatory T cells occurred. The mutant CD4+ T cells adhered poorly to high endothelial venules and exhibited defects in lymph node entrance and egress. The kinetics of chemokine receptor signaling were disturbed, including chemokine- induced integrin activation. Despite the thymic and lymph node egress defects, sphingosine-1-phosphate signaling was not obviously perturbed. This study reveals how RGS proteins modulate Gαi2 signaling to facilitate thymocyte egress and T cell trafficking.
Reactive Oxygen Species–Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation–Induced Reactive Granulopoiesis
Authors: Zhu Haiyan , Kwak Hyun-Jeong , Liu Peng , Bajrami Besnik , Xu Yuanfu , Park Shin-Young , Nombela-Arrieta Cesar , Mondal Subhanjan , Kambara Hiroto , Yu Hongbo , Chai Li , Silberstein Leslie E. , Cheng Tao , Luo Hongbo R. 
Published: February 2017

Abstract
Both microbial infection and sterile inflammation augment bone marrow (BM) neutrophil production, but whether the induced accelerated granulopoiesis is mediated by a common pathway and the nature of such a pathway are poorly defined. We recently established that BM myeloid cell–derived reactive oxygen species (ROS) externally regulate myeloid progenitor proliferation and differentiation in bacteria-elicited emergency granulopoiesis. In this article, we show that BM ROS levels are also elevated during sterile inflammation. Similar to in microbial infection, ROS were mainly generated by the phagocytic NADPH oxidase in Gr1+ myeloid cells. The myeloid cells and their ROS were uniformly distributed in the BM when visualized by multiphoton intravital microscopy, and ROS production was both required and sufficient for sterile inflammation–elicited reactive granulopoiesis. Elevated granulopoiesis was mediated by ROS-induced phosphatase and tensin homolog oxidation and deactivation, leading to upregulated PtdIns(3,4,5)P3 signaling and increased progenitor cell proliferation. Collectively, these results demonstrate that, although infection-induced emergency granulopoiesis and sterile inflammation–elicited reactive granulopoiesis are triggered by different stimuli and are mediated by distinct upstream signals, the pathways converge to NADPH oxidase–dependent ROS production by BM myeloid cells. Thus, BM Gr1+ myeloid cells represent a key hematopoietic niche that supports accelerated granulopoiesis in infective and sterile inflammation. This niche may be an excellent target in various immune-mediated pathologies or immune reconstitution after BM transplantation.
WHO HAS THERAPY-RELATED AML?
Authors: Gale Robert , Bennett John M. , Hoffman F. Owen 
Published: February 2017

Therapy-related leukemia or therapy-related myeloid neoplasm are widely-used terms to designate leukemia developing in persons who previously received anti-cancer therapy (for example, see references 1, 2), especially if the prior anti-cancer therapy included drugs such as alkylators, DNA-intercalators, topoisomerase-2-inhibitors, purines and/or ionizing radiations. Sometimes specific genes such as AML1, EVI1, NRAS or MLL are mutated by therapy or gene variants are produced which activate mutagens or interfere with DNA repair, such FANC, NQ01 or AML2. 3-5 But how can we know if AML in someone is a therapy-related?Keywords: Therapy-related leukemia; alkylators; ionizing radiations; Topoisomerase Inhibitors; DNA Repair
Repeatability of ultrasound in assessment of distal biceps brachii tendon
Authors: Smart Rowan R. , Richardson Cydney M. , Jakobi Jennifer M. 
Published: March 2017

Objective: Examine the repeatability of ultrasound imaging for capturing cross sectional area (CSA), tendon length and elongation of the distal biceps brachii (dBB) tendon at rest and during submaximal elbow flexion contractions. The secondary purpose was to assess the influence of these architectural measures on tendon mechanics of stress and strain.Methods: Within a testing session and between two days CSA, tendon length and elongation of the dBB were captured with ultrasound. Measures were compared within a session and between days. Pearson’s correlations were performed to determine the intra-class correlation coefficients. Bland and Altman plots were used to identify the agreement between measures as well as the bias in measurements. Paired T-test were performed to ensure the calculated variables did not differ between days. Results: Resting tendon CSA was repeatable and strongly correlated (r = 0.98) within a session and between days; however, modest differences were observed in resting tendon length between days (1.8 mm) although values were correlated (r = 0.98). During submaximal contractions of 10%-80% maximal tendon elongation (r = 0.83) and CSA (r = 0.98) were also repeatable. From the measures of elongation and CSA, the calculated values of tendon strain (r = 0.97) and stress (r = 0.96) were also repeatable.Conclusions: Elongation and CSA of the dBB tendon captured with ultrasound are repeatable between testing sessions. Fromthese measures tendon mechanics can be calculated to define the tendon’s role in upper limb tasks, long-term adaptation anddiagnostics.
Conceptualization and Measurement of Market Orientation: A Review with a Roadmap for Future Research
Authors: Dursun Turkan , Kilic Ceyhan 
Published: February 2017

The purpose of this study is to review the existing research on the definition, conceptualization and measurement of market orientation and to provide guidance on the direction of future research in this area. Even though the number of research studies on market orientation has increased substantially, there is still no agreement among scholars regarding how to define market orientation, how broad its scope is, and how to measure it. Although the number of market orientation measurement scales has increased over the years, there is still limited research on how to differentiate between the various measures of market orientation. It is hoped that this review will provide researchers a deeper understanding of the scope of market orientation, help them select a suitable market orientation scale for their studies, and guide them in a more productive research path on the definition and measurement of market orientation.