bluuebunny/crossref_metadata_2025_split huggingface dataset:
Summer Peaks in Uptake of Human Papillomavirus and Other Adolescent Vaccines in the United States
Authors: Moss Jennifer L. , Reiter Paul L. , Rimer Barbara K. , Ribisl Kurt M. , Brewer Noel T. 
Published: December 2015

Abstract
Background: Seasonality in human papillomavirus (HPV) vaccination could have a large impact on national cancer prevention efforts. We hypothesized that uptake of HPV vaccine and other adolescent vaccines in the United States would be highest in the summer.
Methods: Data came from health care provider–verified vaccination records for 70,144 adolescents (ages 13–17 years) from the 2008 to 2012 versions of the National Immunization Survey-Teen. Using the Edwards method for testing annual trends, we examined seasonal patterns in the uptake of HPV and other recommended adolescent vaccines [tetanus, diphtheria, and pertussis (Tdap) booster and meningococcal vaccine]. HPV vaccine initiation (receipt of the first of the three-dose series) data were for female adolescents.
Results: Uptake for HPV and other adolescent vaccines peaked in the summer across years and states (all P &lt; 0.001). Uptake was five times as frequent at the peak as at the trough for HPV vaccine, and HPV vaccine initiation was highest in June, July, and August (percent of doses delivered in these months: 38.7%). The same pattern existed for Tdap booster and meningococcal vaccine. Concomitant (same-day) vaccination of HPV vaccine with other adolescent vaccines also demonstrated summer peaks each year nationally (all P &lt; 0.001).
Conclusion: Uptake of adolescent vaccines increased dramatically in summer months. These summer peaks are an important opportunity for interventions focused on concomitant vaccination.
Impact: The potential cancer prevention impact of HPV vaccination programs could be increased, for example, by delivering messages about concomitant vaccination during the summer, when adolescents and their parents might be most open to them. Cancer Epidemiol Biomarkers Prev; 25(2); 274–81. ©2015 AACR.
The Prognostic and Predictive Value of Soluble Type IV Collagen in Colorectal Cancer: A Retrospective Multicenter Study
Authors: Rolff Hans Christian , Christensen Ib Jarle , Vainer Ben , Svendsen Lars Bo , Eefsen Rikke Løvendahl , Wilhelmsen Michael , Lund Ida Katrine , Høyer-Hansen Gunilla , Nielsen Hans Jørgen , Illemann Martin 
Published: December 2015

Abstract
Purpose: To investigate the prognostic and predictive biomarker value of type IV collagen in colorectal cancer.
Experimental Design: Retrospective evaluation of two independent cohorts of patients with colorectal cancer included prospectively in 2004–2005 (training set) and 2006–2008 (validation set). Plasma samples were available from 297 (training set) and 482 (validation set) patients. Type IV collagen determinations were performed using an ELISA. From the training set, 222 tumors were available for IHC. Clinical and follow-up data were retrieved from patient files and national registries.
Results: High levels of type IV collagen showed independent prognostic significance in both cohorts with hazard ratios (HRs; for a one-unit change on the log base 2 scale) of 2.25 [95% confidence intervals (CIs), 1.78–2.84; P &lt; 0.0001] and 2.24 (95% CI, 1.75–2.86; P &lt; 0.0001) for the training and validation set, respectively. The prognostic impact was present both in patients with metastatic and nonmetastatic disease. The predictive value of the marker was investigated in stage II and III patients. In the training set, type IV collagen was prognostic both in the subsets of patients receiving and not receiving adjuvant antineoplastic therapy. However, in the validation set, the prognostic effect of the marker vanished when looking at patients who received adjuvant antineoplatic therapy (HR 0.90; 95% CI, 0.42–1.93) but was still present in the group not receiving adjuvant chemotherapy (HR 2.88; 95% CI, 1.98–4.21).
Conclusions: The results indicate clinical validity of type IV collagen as a prognostic biomarker in colorectal cancer, although the suggested predictive role of the marker should be validated. Clin Cancer Res; 22(10); 2427–34. ©2015 AACR.
Native LDL promotes differentiation of human monocytes to macrophages with an inflammatory phenotype
Authors: Moore Xiao-Lei , Fang Lu , Sviridov Dmitri , Chin-Dusting Jaye , Andrews Karen L. , Al-Sharea Annas , Lee Man Kit Sam , Murphy Andrew J. 
Published: December 2015

SummaryRecruitment of monocytes in atherosclerosis is dependent upon increased levels of plasma lipoproteins which accumulate in the blood vessel wall. The extracellular milieu can influence the phenotype of monocyte subsets (classical: CD14++CD16-, intermediate: CD14+CD16+ and non-classical: CD14dimCD16++) and macrophages (M1 or M2) and consequently the initiation, progression and/or regression of atherosclerosis. However, it is not known what effect lipoproteins, in particular native low-density lipoproteins (nLDL), have on the polarisation of monocyte-derived macrophages. Monocytes were differentiated into macrophages in the presence of nLDL. nLDL increased gene expression of the inflammatory cytokines TNFα and IL-6 in macrophages polarised towards the M1 phenotype while decreasing the M2 surface markers, CD206 and CD200R and the anti-inflammatory cytokines TGFβ and IL-10. Compared to the classical and intermediate subsets, the non-classical subset-derived macrophages had a reduced ability to respond to M1 stimuli (LPS and IFNγ). nLDL enhanced the TNFα and IL-6 gene expression in macrophages from all monocyte subsets, indicating an inflammatory effect of nLDL. Further, the classical and intermediate subsets both responded to M2 stimuli (IL-4) with upregulation of TGFβ and SR-B1 mRNA; an effect, which was reduced by nLDL. In contrast, the non-classical subset failed to respond to IL-4 or nLDL, suggesting it may be unable to polarise into M2 macrophages. Our data suggests that monocyte interaction with nLDL significantly affects macrophage polarisation and that this interaction appears to be subset dependent.Supplementary Material to this article is available online at www.thrombosis-online.com.
Impacts of ENSO on Philippine Tropical Cyclone Activity
Authors: Corporal-Lodangco Irenea L. , Leslie Lance M. , Lamb Peter J. 
Published: December 2015

Abstract
This study investigates the El Niño–Southern Oscillation (ENSO) contribution to Philippine tropical cyclone (TC) variability, for a range of quarterly TC metrics. Philippine TC activity is found to depend on both ENSO quarter and phase. TC counts during El Niño phases differ significantly from neutral phases in all quarters, whereas neutral and La Niña phases differ only in January–March and July–September. Differences in landfalls between neutral and El Niño phases are significant in January–March and October–December and in January–March for neutral and La Niña phases. El Niño and La Niña landfalls are significantly different in April–June and October–December. Philippine neutral and El Niño TC genesis cover broader longitude–latitude ranges with similar long tracks, originating farther east in the western North Pacific. In El Niño phases, the mean eastward displacement of genesis locations and more recurving TCs reduce Philippine TC frequencies. Proximity of La Niña TC genesis to the Philippines and straight-moving tracks in April–June and October–December increase TC frequencies and landfalls. Neutral and El Niño accumulated cyclone energy (ACE) values are above average, except in April–June of El Niño phases. Above-average quarterly ACE in neutral years is due to increased TC frequencies, days, and intensities, whereas above-average El Niño ACE in July–September is due to increased TC days and intensities. Below-average La Niña ACE results from fewer TCs and shorter life cycles. Longer TC durations produce slightly above-average TC days in July–September El Niño phases. Fewer TCs than neutral years, as well as shorter TC durations, imply less TC days in La Niña phases. However, above-average TC days occur in October–December as a result of higher TC frequencies.
Relationship between the Self-Rating Anxiety Scale score and the success rate of 64-slice computed tomography coronary angiography
Authors: Li Hui , Jin Dan , Qiao Fang , Chen Jianchang , Gong Jianping 
Published: December 2015

Objective Computed tomography coronary angiography, a key method for obtaining coronary artery images, is widely used to screen for coronary artery diseases due to its noninvasive nature. In China, 64-slice computed tomography systems are now the most common models. As factors that directly affect computed tomography performance, heart rate and rhythm control are regulated by the autonomic nervous system and are highly related to the emotional state of the patient. The aim of this prospective study is to use a pre-computed tomography scan Self-Rating Anxiety Scale assessment to analyze the effects of tension and anxiety on computed tomography coronary angiography success. Methods Subjects aged 18–85 years who were planned to undergo computed tomography coronary angiography were enrolled; 1 to 2 h before the computed tomography scan, basic patient data (gender, age, heart rate at rest, and family history) and Self-Rating Anxiety Scale score were obtained. The same group of imaging department doctors, technicians, and nurses performed computed tomography coronary angiography for all the enrolled subjects and observed whether those subjects could finish the computed tomography coronary angiography scan and provide clear, diagnostically valuable images. Participants were divided into successful (obtained diagnostically useful coronary images) and unsuccessful groups. Basic data and Self-Rating Anxiety Scale scores were compared between the groups. Results The Self-Rating Anxiety Scale standard score of the successful group was lower than that of the unsuccessful group ( P = 0.001). As the Self-Rating Anxiety Scale standard score rose, the success rate of computed tomography coronary angiography decreased. Conclusions The Self-Rating Anxiety Scale score has a negative relationship with computed tomography coronary angiography success. Advances in knowledge Anxiety can be a disadvantage in computed tomography coronary angiography examination. The pre-computed tomography coronary angiography scan Self-Rating Anxiety Scale score may be a useful tool for assessing whether a computed tomography coronary angiography scan will be successful or not.
Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia
Authors: Sheikh Virginia , Porter Brian O. , DerSimonian Rebecca , Kovacs Stephen B. , Thompson William L. , Perez-Diez Ainhoa , Freeman Alexandra F. , Roby Gregg , Mican JoAnn , Pau Alice , Rupert Adam , Adelsberger Joseph , Higgins Jeanette , Bourgeois Jeffrey S. , Jensen Stig M. R. , Morcock David R. , Burbelo Peter D. , Osnos Leah , Maric Irina , Natarajan Ven , Croughs Therese , Yao Michael D. , Estes Jacob D. , Sereti Irini 
Published: December 2015

Key PointsrhIL-7 therapy was well tolerated in patients with ICL. rhIL-7 led to increases in CD4 T cells in both peripheral blood and tissues.
Perceptions of Prognostic Risks in Chronic Kidney Disease: A National Survey
Authors: Chiu Helen H. L. , Tangri Navdeep , Djurdjev Ognjenka , Barrett Brendan J. , Hemmelgarn Brenda R. , Madore François , Rigatto Claudio , Muirhead Norman , Sood Manish M. , Clase Catherine M. , Levin Adeera 
Published: December 2015

Background: Predicting the clinical trajectories of chronic kidney disease (CKD) to discern personalized care remains a complex challenge in nephrology. Understanding the appropriate risk thresholds and time frame associated with predicting risks of key outcomes (kidney failure, cardiovascular (CV) events, and death) is critical in facilitating decision-making. As part of an exploratory research and practice support needs assessment, we aimed to determine the importance of the time frames for predicting key outcomes, and to assess the perceived demand for risk prediction tools among Canadian nephrologists. Methods: A web-based survey was developed by a pan-Canadian expert panel of practitioners. Upon pre-test for clarity and ease of completion, the final survey was nationally deployed to Canadian nephrologists. Anonymous responses were gathered over a 4-month period. The results were analyzed using descriptive statistics. Results: One hundred eleven nephrologists responded to our survey. The majority of the respondents described prediction of events over time frames of 1–5 years as being “extremely important” or “very important” to decision-making on a 5-point Likert scale. To plan for arteriovenous fistula referral, the respondents deemed thresholds which would predict probability of kidney failure between >30 and >50 % at 1 year, as useful, while many commented that the rate of progression should be included for decision-making. Over 80 % of the respondents were not satisfied with their current ability to predict the progression to kidney failure, CV events, and death. Most of them indicated that they would value and use validated risk scores for decision-making. Conclusions: Our national survey of nephrologists shows that the risk prediction for major adverse clinical outcomes is valuable in CKD at multiple time frames and risk thresholds. Further research is required in developing relevant and meaningful risk prediction models for clinical decision-making in patient-centered CKD care.
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis
Authors: Zuo Yan , Oh Wonkyung , Ulu Arzu , Frost Jeffrey A. 
Published: December 2015

Abstract
Ras homolog (Rho) family small GTPases are critical regulators of actin cytoskeletal organization, cell motility, proliferation, and survival. Surprisingly, the large majority of the studies underlying our knowledge of Rho protein function have been carried out in cultured cells, and it is only recently that researchers have begun to assess Rho GTPase regulation and function in vivo. The purpose of this review is to evaluate our current knowledge of Rho GTPase function in mouse mammary gland development, tumorigenesis and metastasis. Although our knowledge is still incomplete, these studies are already uncovering important themes as to the physiological roles of Rho GTPase signaling in normal mammary gland development and function. Essential contributions of Rho proteins to breast cancer initiation, tumor progression, and metastatic dissemination have also been identified.
A spatiotemporal observation of EndMT and mesenchymal cell colonization at the onset of human cardiac valve development
Authors: Monaghan Michael G. , Linneweh Miriam , Liebscher Simone , Van Handel Ben , Layland Shannon L. , Schenke-Layland Katja 
Published: December 2015

Elucidation of mechanisms in semilunar valve development may enable the development of new therapies. Here, we found differences in proliferation-associated genes and genes repressed by vascular endothelial growth factor between human semilunar valves from first and second trimester valve leaflets. The proliferation of valve interstitial cells and ventricular valve endothelial cells (VECs) and cellular density declined from the first to the second trimester. Cytoplasmic expression of nuclear factor of activated T-cells cytoplasmic 1 (NFATc-1) in VECs (4 weeks), and later cells in the leaflet/annulus junction mesenchyme expressing inactive NFATc-1 (5.5-9 weeks) were detected, indicative of EndMT in valvulogenesis. At this leaflet/annulus junction CD44+ cells clustered during elongation (11 weeks), extending toward the tip along the fibrosal layer in second trimester leaflets. Differing patterns of maturation in the fibrosa and ventricularis were detected via increased fibrosal periostin content, which tracked the presence of the CD44+ cells in the second trimester.
We revealed that spatiotemporal NFATc-1 expression actively regulates EndMT during human valvulogenesis, as early as 4 weeks. Additionally, CD44+ cells play a role in leaflet maturation toward the trilaminar structure, possibly via migration of VECs undergoing EndMT, which subsequently ascend from the leaflet/annulus junction.
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
Authors: Kurtulmus Bahtiyar , Wang Wenbo , Ruppert Thomas , Neuner Annett , Cerikan Berati , Viol Linda , Dueñas-Sánchez Rafael , Gruss Oliver J. , Pereira Gislene 
Published: December 2015

ABSTRACT
Ciliogenesis initiates at the mother centriole through a series of events that include membrane docking, displacement of cilia-inhibitory proteins and axoneme elongation. Centriolar proteins, in particular at distal and subdistal appendages, carry out these functions. Recently, cytoplasmic complexes named centriolar satellites have also been shown to promote ciliogenesis. Little is known about the functional and molecular relationship between appendage proteins, satellites and cilia biogenesis. Here, we identified the WD-repeat protein 8 (WDR8, also known as WRAP73) as a satellite and centriolar component. We show that WDR8 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component Cep135. Cep135 is required for the recruitment of WDR8 to centrioles. Depletion experiments revealed that WDR8 and Cep135 have strongly overlapping functions in ciliogenesis. Both are indispensable for ciliary vesicle docking to the mother centriole and for unlocking the distal end of the mother centriole from the ciliary inhibitory complex CP110–Cep97. Our data thus point to an important function of centriolar proximal end proteins in ciliary membrane biogenesis, and establish WDR8 and Cep135 as two factors that are essential for the initial steps of ciliation.
One-Pot Facile Synthesis of Water-Soluble Cationic Aluminum(III) Porphyrins in a Unique Heterogeneous System at Ambient Temperature
Authors: Mathew Siby , Kuttassery Fazalurahman , Yamamoto Daisuke , Onuki Satomi , Nabetani Yu , Tachibana Hiroshi , Inoue Haruo 
Published: December 2015

Abstract
Water-soluble cationic 5,10,15,20-tetra(N-methyl-4′-pyridiniumyl)porphyrinatoaluminum(III) (AlTMPyP) has been synthesized by novel one-pot reaction between the parent free-base porphyrin and trimethyl aluminum in a heterogeneous system at ambient temperature. Subsequent addition of water results in the formation of hydroxy-coordinated AlTMPyP(OH) in high yield (96%).
The Ways of Bertrand Paradox Overcoming in Light of Tasks of System Modeling
Authors: Высокий  , Vysokiy Victor 
Published: December 2015

In this article there are offered the ways of Bertrand paradox overcoming
existing in microeconomics. There is employed an inversion approach for
a linear method regarding the market competition models by analogy with
the gravitational traffic models. By the way the analogies with the regularities
in electrical engineering are also revealed. The new ways of modeling of the
territorially dispersed systems are open, for example, settlements systems,
whose elements are economically linked.
In this article there are used the scientific results achieved with the support
of The Russian Foundation for Basic Research for the project No. 13-07-91151,
entitled as «The Academic Exchange on Simulation of Urban Spatial Development
between Russia and China», made under supervision of F.S. Kudryavtsev.
MAGNETIC PROPERTIES OF Cu2+ SUBSTITUTED BaFe12-xCuxO19 (x= 0.1,0.2,0.3,..., 4)
Authors: Humaidi Syahrul , S Ratna A , S Tua Raja , S Seri Dermayu , S Perdamean 
Published: December 2015

<p>Permanent magnet Barium M-Hexaferrite, BaFe<sub>12-x </sub>Cu<sub>x</sub> O<sub>19 </sub> was synthesized with a wide range of x (x = 0.1, 0.2, …, 3 and 4mole% respectively). The precursor was made by mixing BaCO<sub>3</sub> powder and Fe<sub>2</sub>O<sub>3</sub> powder, whereas CuO powder was used as additive. The powders were mixed together by wet milling in distilled water medium for 20 hours. The powders had been dried at a temperature of 100<sup>0</sup>C for 24 h before calcined at a temperature of 1100<sup>0</sup>C for 2 hours. The powders were then grained to prepare 400 mesh (38 µm) in diameter. The samples density was determined by using Archimedes method, magnetic properties by using permagraph, crystal structure by XRD-pattern and microwave absorbing properties using VNA. The hysteresis curve showed that the value of magnetic field ranging from 43.36 G to 100.42 G , remanence magnetic induction (Br) 20G-320G, coercivity (HcJ) 1.07 kOe to 9.22 kOe and energy production (BH) max from 0.05kGOe to 0.92 kGOe with a density from 3.82 g/cm<sup>3</sup> to 5.2 g/cm<sup>3</sup>. The effect of Cu doping tent to increase the value of density with an optimum magnetic properties at x=0.3%mole.</p>
BENITO DEL POZO, P. (Dir.) (2014): Planificación territorial y desarrollo del suelo empresarial en España. Cizur Menor (Navarra): Aranzadi, 242 pp.
Authors: Feo Parrondo Francisco , Moliní Fernando 
Published: December 2015

A lo largo de las últimas décadas ha adquirido en España un notable recimiento la preocupación por la planificación territorial y la regulación de suelos empresariales. En la obra aquí reseñada este tema se desarrolla y actualiza para los casos de Galicia, Asturias, Cantabria, Castilla-León y Navarra. El libro resulta imprescindible para conocer los cambios que sobre el suelo productivo se han producido en dichas Comunidades Autónomas (CC.AA) a lo largo de las últimas décadas. El trabajo aborda un tema de gran interés, proporciona un análisis riguroso, ofrece información valiosa y está muy bien escrito. Cabe destacar el mérito que tiene el que un proyecto de investigación se publique en una obra de tanta calidad y en una editorial de tanto prestigio. Lo que sí habría sido conveniente es que el título se refiriese únicamente al noroeste de España y no a su conjunto.
Students’ Attitude Towards Self-Study: A Case of College Study Programmes in Social Sciences
Authors: Klizaitė Jūratė , Arlauskienė Renata 
Published: December 2015

Abstract
In recent years, the significance of quality in higher education has been emphasised, with special emphasis placed on the opinion of students. The present paper analyses the attitude of college students towards self-study assignments as a factor essential for the development of generic competences, presently related to the widely discussed educational paradigms, such as student-oriented learning, metacognitive study strategies, and holistic personality development. The changes in the educational paradigms and recent fundamental and applied research reveal the importance of student independent work in the study process and the development of abilities necessary for learning, the enhancing of motivation, and the promotion of reflection and critical thinking. A new attitude towards the development of student thinking and the enhancing of their activity has been formed. Students‘ generic abilities necessary for independent work and relevant for the solution of the problems arising in their professional activity in the future (monitoring, organisation, communication, work in a team, etc.), as well as their learning motivation, are different. Student selfstudy activity is a major integral part of college studies, and it has to be appropriately organised, monitored, assessed, and provided with the most important sources of information and technologies. The research aim is to identify the views of college students on self-study assignments in the process of implementation of study programmes in social sciences. The analysis of the outcomes of the student survey and of the research of other authors is expected to lead to the identification of the weaknesses in the organisation of self-study activities and to contribute to the forecasting of the improvement trends and the development of generic competences that integrate individual knowledge, abilities, and attitudes into a whole and and consciously channel them in the chosen direction.