bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Perhatian Orang Tua dengan Kedisiplinan Belajar Peserta Didik di TPA Mushalla Al-Hikmah Padusunan Kota Pariaman
Authors: Diana Novia , Solfema Solfema 
Published: September 2024

Penelitian ini dilatarbelakangi oleh: kurangnya kedisiplinan belajar peserta didik dalam proses pembelajaran di TPA Mushalla Al-Hikmah Padusunan Kota Pariaman. Penelitian ini bertujuan untuk mengetahui: (1) Gambaran perhatian orang tua pada peserta didik; (2) Gambaran kedisiplinan belajar dari peserta didik. (3) Hubungan perhatian orang tua dengan kedisiplinan belajar Peserta didik di TPA Mushalla Al-Hikmah Padusunan Kota Pariaman. Pendekatan penelitian ini yaitu: kuantitatif dengan jenis penelitian korelasional. Populasi penelitian yaitu peserta didik Kelompok Al-Quran di TPA Mushalla Al-Hikmah Kampung Baru Padusunan Kota Pariaman. Sampel diambil dengan teknik simple random sampling. Instrumen yang dipakai dalam pengumpulan data yaitu angket. Tekik analisis data berupa rumus persentase dan rumus pearson product moment correlation. Hasil penelitian menujukan bahwa: (1) Perhatian orang tua pada peserta didik dikategorikan rendah; (2) Kedisiplinan belajar peserta didik pada peserta didik dikategorikan rendah; (3) Terdapat Hubungan yang sangat Signifikan antara Perhatian Orang Tua dengan Kedisiplinan Belajar Peserta Didik di TPA Mushalla Al-Hikmah Padusunan Kota Pariaman. Hal ini bisa dilihat dari hasil analisis menggunakan rumus product moment bahwa nilai yaitu: rxy: 0,977 > 0,361, yang artinya terdapat hubungan.
Insomnia Sebagai Ide Dalam Karya Lukis Abstrak Figuratif
Authors: Taupik Aulia Zikra , Sami Yasrul 
Published: September 2024

Artikel ini membahas tentang insomnia yang menjadi rancangan ide dalam sebuah karya lukis. Dalam mewujudkan karya seni lukis ini, penulis menganggap fenomena ini sebagai suatu yang menarik karena insomnia bisa digunakan sebagai objek inspirasi dalam berkarya. Pengggarapan ide-ide dalam proses pencipaan memerlukan berbagai tahapan, demi terlaksanakannya kegiatan penciptaan sesuai konsep. Berikut adalah berbagai tahapan yang dilakukan penulis untuk mewujudkan karya berdasarkan konsep. Tahap tersebut diantaranya tahap persiapan, elaborasi, sintesis, realisasi konsep dan penyelesaian. Tujuan dari karya tentang Insomnia ini yaitu untuk memvisualisasikan sebuah bentuk ekspresi ke dalam seni lukis yang menjadikan diri sendiri sebagai contoh pembelajaran. memberitahu apa itu Insomnia dan diharapkan dari karya ini timbul rasa ingin tahu dari siapa saja yang melihat karya ini tentang apa itu Insomnia, setelah mengetahui apa itu Insomnia kita akan lebih bisa memahami dan menerima bahwa setiap orang memiliki gangguan tidur dengan penyebab kesehatan yang berbeda pada manusia. Dalam pembuatan karya ini sendiri pasti ada banyak kendala dalam mencari informasi tentang judul, pengetikan proposal dan memvisualisasikan dalam bentuk karya Lukisan. Setelah melalui proses yang Panjang dan beberapa hal yang sempat membuat terlambatnya proses karya akhir ini, akhirnya terciptalah sepuluh karya tentang Gangguan Tidur dalam karya Lukis dengan judul sebagai berikut: Pengen Tidur, Overthinking, Three Levels, Beda Server, Abnormal, Labirin, Terbalik, Solusi Stress, Sama Rasa.
Evaluation of the relationship between ACE2 G8790A and AT2R A1675G gene polymorphisms in COVID-19 patients with and without lung involvement
Authors: Akcilar Raziye , Kocak Fatma Emel , Kar Fatih , Isiklar Ozben Ozden , Atlanoglu Sahinde , Genc Ozlem , Yaman Fatima 
Published: September 2024

Abstract

Background
The SARS-CoV-2 virus produces severe acute respiratory syndrome. The severity of coronavirus disease 2019 (COVID-19) infection is determined by a number of factors, including inherited ones.

Objectives
Our goal is to investigate the link between ACE2 G8790A (rs2285666) and AT2R A1675G (rs14035430) gene polymorphisms in COVID-19 patients with and without lung involvement.

Methods
A total of 160 COVID-19 patients were divided into 2 groups based on their clinical symptoms: those without lung involvement (control group) and those with lung involvement (infected group). The ACE2 G8790A and AT2R A1675G gene polymorphisms were analyzed using the PCR-RFLP methods.

Results
The GG genotype, G allele of ACE2 G8790A, and GG genotype of AT2R A1675G were significantly higher in the control group and had a protective effect against COVID-19 as well as decreased the development of lung involvement (OR = 0.29, 95% CI = 0.10–0.84; OR = 0.40, 95% CI = 0.22–0.72; and OR = 0.33, 95% CI = 0.14–0.78, respectively). Moreover, we found that the AA genotype, A allele of ACE2 G8790A, and AG genotype of AT2R A1675G increased the risk of COVID-19 in the infected group (OR = 3.50, 95% CI = 1.18–10.3; OR = 2.49, 95% CI = 1.39–4.48; and OR = 3.08, 95% CI = 1.28–7.38, respectively).

Conclusions
These results revealed that a greater frequency of COVID-19 lung involvement in the Turkish population was connected with the AA genotype, the A allele of ACE2 G8790A, and the AG genotype of AT2R A1675G.
TPH1 inhibits bladder tumorigenesis by targeting HIF-1α pathway in bladder cancer
Authors: Ren Jianwei , Mo Zhiting , Deng Xia , Ren Minghui , Ren Hailong , Jin Jie , Zhang Huihui 
Published: September 2024

Abstract

Background
BCa is the most common cancer of the urinary system. TPH1 has been reported to be associated with distinct tumorigenesis. However, the role of TPH1 in BCa remains to be clarified.

Objectives
Our aim is to demonstrate the molecular mechanism of TPH1 in BCa carcinogenesis and development.

Methods
In research, we explored the effect of TPH1 on T24 cells. Colony formation, soft agar, and cell proliferation assays were used to determine the survival and proliferative capacity of cells. Moreover, TPH1−/− cell lines were analyzed using CRISP-CAS9, and the recovery experiment was conducted. Realtime fluorescence quantitative PCR (qPCR) and Western blot were used to detect HIF-1α mRNA levels and TPH1 protein.

Results
The TPH1 expression is lower in tumor tissues than in normal tissues. Colony formation, soft agar, and cell proliferation assays revealed that the overexpression of TPH1 declined cells survival. Moreover, the deficiency of TPH1 increased the number of clones. These results suggested that survival rate of TPH1 overexpression was repressed in cells. In addition, we found that HIF-1α activity was significantly downregulated with an increase in TPH1. The transcriptional activity of survivin was increased with TPH1−/− cells. Then, the proliferative ability of TPH1−/− cells was almost similar to the wild type levels with the treatment of LW6, TPH1 might play a major role to repress HIF-1α activity.

Conclusions
Taken together, these results suggested that increasing TPH1 activity could inhibit survival and proliferation of cells via HIF-1α pathway. TPH1 may be a potential target for human BCa therapy.
Predictive model for left main coronary artery or triple vessel disease in patients with chronic coronary syndromes
Authors: Nuchanat Piyanop , Methavigul Komsing 
Published: September 2024

Abstract

Background
Data about prediction of left main coronary artery disease (LMCAD)/three-vessel disease (TVD) in patients with chronic coronary syndromes (CCS) are lacking.

Objectives
This study aimed to develop a model for predicting patients at risk of LMCAD/TVD.

Methods
This study used retrospective data from patients with CCS scheduled for invasive coronary angiography (ICA) and who were retrospectively recruited between January 2018 and December 2020. Predictors were obtained and analyzed by using logistic regression analysis, and generated the prediction score. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. The cut-off value and area under the curve (AUC) were analyzed by using the receiver operating characteristic (ROC) curve.

Results
We recruited 162 patients with CCS. There were 75 patients in the non-LMCAD/TVD and 87 patients in the LMCAD/TVD groups. After the multivariate analysis, new onset of heart failure (HF) or left ventricular systolic dysfunction (LVSD) and suspected CAD, ST elevation (STE) in aVR, STE in V1 and lateral ST depression (STD) were associated with increased risk of LMCAD/TVD. Based on these 4 predictors, the prediction score was created. The cut-off value of the prediction score by using ROC curve analysis was 3.0. The sensitivity, specificity, PPV, and NPV were 71.26%, 86.67%, 86.11%, and 72.22%, respectively, with an AUC of 0.855.

Conclusions
The CCS patients with new onset of HF or LVSD and suspected CAD, STE in aVR, and STE in V1 and lateral STD were associated with increased risk of LMCAD/TVD. The novel prediction score could predict LMCAD/TVD in those patients with acceptable sensitivity, specificity, PPV, and NPV.
The Importance of Green Real Estate Planning and Development
Authors: Assina Ayoob Khan Mohamed Hamid Ali , Srinivasan Nirmalkumar , Lapuke Sanda , Bode Ilmars 
Published: September 2024

Abstract
Green real estate (GRE) planning and development have become critical to achieving environmental sustainability and urban resilience. This paper explores the importance of incorporating eco-friendly techniques into real estate developments, with a focus on lowering carbon footprints, increasing energy efficiency, and encouraging sustainable land use. Regulatory rules, market demand, and technical breakthroughs are all key drivers of green development. The study emphasises the advantages of green buildings (GB), including better health outcomes, lower costs, and higher property values. By evaluating case studies and current research, this study emphasises the importance of stakeholders implementing sustainable practices to reduce environmental consequences and promote long-term economic growth. The findings call for a coordinated approach between governments, developers, and communities to ensure the success of green real estate programs.
Optimal Monetary Policy Framework in an Emerging Market Economy under Sanctions Pressure and Restrictions on Capital Flows
Authors: Kharitonchik Anatoly 
Published: September 2024

Abstract
The study evaluates the effectiveness of monetary policy regimes that can serve as the basis for economic policy strategies in emerging economies. Based on the macroeconomic gap model for Belarus, simulations of the strong shock impact on the economy using different monetary policy regimes have been implemented. The effects of capital flow restrictions on the stabilization capacity of monetary policy regimes have been examined. Given the existing sanctions and internal capital controls, the most preferable regime for Belarus is a flexible inflation targeting. In transforming the economy and political system towards the inclusivity of political and economic institutions, applying a flexible price-level targeting can be considered.
The Contribution of the BSC to Strategic Focus and Organisational Performance – Perception of the Mayor Export Companies in Portugal
Authors: Oliveira Cidália , Martins Nayra , Rodrigues Margarida 
Published: September 2024

Abstract

Objective
Managers recognise the ability of the Balanced Scorecard (BSC) to leverage strategic focus and organisational performance. In addition, the BSC is capable of addressing strategic focuses, aligning and monitoring strategic goals.
Considering the strategic focus and organisational performance, various studies have been carried out related to the BSC; however, few studies have delved into the knowledge and relevance recognised by organisations with and without the BSC. Considering the organisations that have implemented the BSC and those that have not, this research empirically demonstrates the real benefits of this tool.

Methodology
A quantitative approach was adopted, using a questionnaire drawn up on the basis of a literature review. The respondents were managers of companies that have implemented the BSC and managers of companies that have not implemented the BSC.

Results and Conclusions
This research shows that the characteristics and benefits of the BSC are confirmed by the managers of the main exporting organisations in Portugal, regardless of whether they have the BSC implemented or not. In companies that do not have the BSC in place, managers agree that if the BSC were implemented, it would support strategic focus and improve the monitoring of organisational performance.

Added Value
The contribution of this research is useful for both academics and professionals, as it highlights the relevance of the BSC with regard to strategic focus and performance management.

Recommendations: The BSC should be used to track strategic focus and organ-isational performance on a monthly basis
Multigraphs from crossword puzzle grid designs
Authors: Coté Ben , Merrill Leanne 
Published: September 2024

Abstract
Crossword puzzles lend themselves to mathematical inquiry. Several authors have already described the arrangement of crossword grids and associated combinatorics of answer numbers [Fer14] [Fer20] [McS16]. In this paper, we present a new graph-theoretic representation of crossword puzzle grid designs and describe the mathematical conditions placed on these graphs by well-known crossword construction conventions.
Mathematizing the Toxin Puzzle
Authors: Wapner Leonard M. 
Published: September 2024

Abstract
A mathematical model of Gregory Kavka’s “Toxin Puzzle” is constructed to provide the optimal course of action for this thought experiment. But the action suggested by the model is irrational, rendering the model useless for the rational player. Yet, it is the failure itself which provides a deeper insight into the nature of intention and mathematical modeling in general.
Tratamentos para bruxismo do sono em crianças e adolescentes
Authors: Castro Thais Almeida , Morais Gleison Silva , Bedim Natiele Resende , Paula Cibelle Costa Colares de 
Published: September 2024

Objetivo: Realizar um levantamento das intervenções mais comuns e dos resultados alcançados por cirurgiões-dentistas no tratamento de crianças e adolescentes diagnosticados com bruxismo do sono. Métodos: Trata-se de uma revisão bibliográfica com delineamento metodológico baseado no Método PRISMA, realizada nas bases de dados SciELO, PubMed/MEDLINE, Cochrane, Web of Science e Bibliografia Brasileira de Odontologia, com período de extração estabelecido entre 2012 e 2022. Resultados: Foram estratificados 121 manuscritos que após passarem pelas etapas de identificação, triagem, elegibilidade e inclusão, resultaram em 13 estudos que apresentaram intervenções de cunho farmacológicos, ortodônticos, homeopáticos, psicológicos e fisioterapêuticos. Todas as pesquisas analisadas ressaltaram a importância de estabelecer um diagnóstico específico a partir da análise etiológica para definir uma abordagem adequada para a criança e o adolescente com bruxismo do sono. Conclusão: Considera-se que há diversas abordagens multidisciplinares e individualizas eficazes no tratamento do bruxismo do sono em crianças e adolescentes. Estas intervenções podem serem ministradas pelo cirurgião-dentista através da utilização de fármacos, aparelhos ortodônticos e tratamentos homeopáticos, assim como, podem ser utilizadas terapias psicológicas e fisioterapêuticas.
Were Mammoths Brought by Mudflows?
Authors: Сергин В.Я. 
Published: September 2024

На ряде поселений конца верхнего палеолита Восточной Европы встречено большое количество костей мамонта. В статье рассмотрена гипотеза, согласно которой скопления возникали в результате гибели животных от селей и плывунных потоков, а человек находил и использовал их. В настоящее время в условиях, характерных для этих памятников, такие опасные явления не возникают. Нет оснований предполагать их проявление в прошлом. Стратиграфия памятников и состояние костей мамонта на них (отсутствие частей скелета, состав, сходная сохранность) свидетельствуют о накоплении костей в результате деятельности человека.
Some Upper Palaeolithic sites in Eastern Europe have revealed a large number of mammoth bones. The paper explores the hypothesis which states that accumulations of these animals occurred because of their death caused by mudflows whereas people found and used them. Dangerous mudflows do not occur in the conditions typical for these sites today. Nothing suggests that there were mudflows in the past. Stratigraphy of the sites and conditions of the mammoth bones at the sites (some parts of the skeleton missing, similar state of preservation) demonstrate that the bones were accumulated in the course of human activity.
CULT AND MEMORIAL COMPLEXES OF THE SCYTHIAN TIME ON THE MIDDLE DON
Authors: Володин С.А. 
Published: September 2024

Погребальные памятники скифской эпохи (V–IV вв. до н. э.) на территории Среднего Дона представляют собой в большинстве случаев захоронения под курганными насыпями. На данный момент изучено частично и целиком 10 некрополей. В трех из них, а именно в могильниках Терновое – Колбино, Мастюгино и Староживотинное, были зафиксированы «пустые курганы». Исследователи по-разному трактовали эти комплексы: как кенотафы, святилища или остатки кремаций. В данной работе предлагается интерпретация среднедонских курганов без захоронений скифского времени как культово-поминальных комплексов, тесно связанных с огненными ритуалами. Практика сооружения комплексов подобного назначения была широко распространена на территории скифо-сибирского мира, наибольшие же аналогии среднедонским культово-поминальным комплексам обнаруживаются на территории Днепровской лесостепи.
Burial sites of the Scythian time (V–IV centuries BC) in the Middle Don region are mostly represented by burials deposited under kurgan mounds. At the moment, 10 cemeteries have been investigated partially entirely. In three of them, namely, the cemeteries of Ternovoe-Kolbino, Mastyugino and Starozhivotinnoe, so-called “empty kurgans” were recorded. The researchers interpreted the associations in question differently: as cenotaphs, sanctuaries or remains of cremated burials. This paper suggests an interpretation of the Middle Don kurgans of Scythian time without burials as a cult and memorial complexes, closely associated with fire rituals. The practice of constructing complexes of similar purpose was widespread in the Scythian-Siberian world, the closest analogies to the Middle Don cult and memorial complexes are known in the territory of the Dnieper forest-steppe
DISTURBANCES OF SCYTHIAN GRAVES DURING THE ARCHAIC PERIOD (PRELIMINARY OBSERVATIONS)
Authors: Кузнецова Т.М. 
Published: September 2024

Раскопки скифских курганов в Северном Причерноморье показывают, что большинство захоронений в них было нарушено. Это явление не без основания связывается с различными этапами ограбления скифских гробниц. Однако при сопоставлении погребальных комплексов, расположенных на правом берегу р. Днепр, удалось сделать некоторые наблюдения по поводу нарушений «скифских» памятников, возможно связанных не только с ограблениями. Рассматривались четыре близкие по конструкции могилы в курганах: «Репяховатая Могила» (гробницы № 1 и 2), «Червона Могила» (гробница № 2) и № 407 у с. Журовка (Журавка). Эти памятники объединяются сходными по форме железными навершиями и другими категориями сопроводительного инвентаря. Нарушенными в представленных памятниках оказались лишь мужские (скифские) захоронения, тогда как женские и детские останки потревожены не были. Предварительная оценка характера нарушений позволяет предположить возможность негативного отношения местного населения Правобережной лесостепи к пришедшим в этот регион скифам. Разрушение рассмотренных памятников трудно связать с ограблениями ради наживы, так как, судя по сохранившемуся вещевому комплексу, они не были наполнены драгоценными металлами.
The excavations of Scythian kurgans in the North Pontic area demonstrate that most graves were disturbed. Not without good reason, this phenomenon is linked to looting of the Scythian tombs at different stages. However, comparison of funerary assemblages located on the right bank of the Dnieper helped make some observations about disturbances of «Scythian» sites, possibly, related to processes other than lootings. The paper reports on four graves with similar construction in the following kurgans: Repyakhovataya Mogila (graves No. 1 and 2), Chervonaya Mogila (grave No. 2) and No. 407 near the village of Zhurovka (Zhuravka). These sites exhibit similarities such as iron terminals of similar shape and presence of other categories of grave goods. Only male Scythian graves were found looted while female and children graves were not disturbed. Preliminary assessment of the nature of disturbances suggests possible negative attitude of the local population inhabiting the forest-steppe on the right bank of the Dnieper towards the Scythians who arrived in this region. It is difficult to link disturbances of the sites excavated to looting for the sake of profit because, as suggested by preserved funerary offerings, the graves did not contain items made of precious stones.
Excavations on the Southwest Slope of the Markula Hilfort
Authors: Требелева Г.В. , Хондзия З.Г. , Шведчикова Т.Ю. , Юрков Г.Ю. 
Published: September 2024

Важным открытием 2016 г. стало обнаружение in situ стены у подножия склона холма с городищем с юго-западной стороны. В том же году было начато исследование этого склона. В ходе шурфовки было обнаружено женское погребение IV в. н. э., сопровождавшееся инвентарем, в том числе бусинами из пасты, а также слой с чернолаковой керамикой. Раскопки 2017 г. подтвердили наличие эллинистического слоя.
The find of a wall in situ at the foot of the hill slope with a hillfort on the southwestern part was an important discovery made in 2016. Examination of the slope was launched in the same year. The test boring discovered a female grave of the 4th century as well as a layer with black-glazed ceramics. The 2017 excavations confirmed presence of a Hellenistic layer at the site.