bluuebunny/crossref_metadata_2025_split huggingface dataset:
Campus management process dynamics – Finnish and Australian practices
Authors: Rytkönen Eelis , Heywood Christopher , Nenonen Suvi 
Published: March 2017

PurposeThis paper aims to outline campus management process dynamics that are affected by glocalization, changing funding structures and digitalization, and answer: How do glocalization, changing funding structures and digitalization challenge university campus management? and What implications do the challenges have on campus management processes?Design/methodology/approachLiterature overview discusses how glocalization, changing funding structures and digitalization affect campus management. Empirical part explores how these forces affect management processes through 36 interviews on multiple embedded cases in the main campuses of Aalto University in Finland and the University of Melbourne in Australia.FindingsMajor challenges include future foresight, institutional sharing, economical paucity and functional flexibility. Heterogeneous user behaviors challenge absolute spatial measures as bases for designing learning and working environments. Finding a balance between long-haul portfolio maintenance for the university and future users and short-haul flexible pilots for the current user communities is crucial.Research limitations/implicationsThe results derive from interviews of 36 campus management professionals from two campus management organizations limiting the validity and the reliability of the study. Further studies should be conducted by replicating the study in another context, by interviewing end users and clients and by investigating case investments and impacts over time.Practical implicationsCampus managers can answer the challenges through practical applications such as big data collection and sharing in physical environments, integrated service provision to thematic communities, cross-pollination of user communities and open access to information and infrastructure services.Originality/valueThis paper provides insights and tools to strategic alignment by comparing campus management of two fundamentally different systems in the context of higher education and on-going digitalization.
From strategic orientation to social media orientation
Authors: Dutot Vincent , Bergeron François 
Published: March 2017

PurposeThe purpose of this paper is to develop and test a framework of small and medium enterprises’ (SMEs) strategic orientation (SO) and its impact on social media performance. Moreover, it introduces a new concept, social media orientation (SMO) (composed of sales and business development (SBD) and visibility) to add in the model.Design/methodology/approachA quantitative approach was used and, based on a study of 257 SMEs, analyses were performed. A smartPLS analysis was judged appropriate regarding the sample size.FindingsResults show that entrepreneurial orientation (EO) and customer orientation have a positive influence on SBD which in turn has a positive influence on social media performance. Visibility is positively influenced by EO and has an indirect effect on social media performance. Social media performance is therefore directly influenced by SBD and indirectly by visibility.Research limitations/implicationsThe authors complete previous research that called for the introduction of different SO on a same study and go further as the author highlight the role of EO on visibility (and not only on business or performance). A second contribution lies in the conceptualization of SMO (defined here with SBD and visibility) and third in the measurement of social media performance through growth and attention.Practical implicationsSMEs first need to develop their visibility, and then link it to SBD.Originality/valueThis research is one of the first to explore SMEs’ SO on social media and proposes a new concept defined as SMO. It gives SMEs future direction on how to perform on these platforms.
Business innovation in Indian software industries
Authors: Baragde Dileep , Baporikar Neeta 
Published: March 2017

PurposeBusiness innovation should enable the achievement of goals across the entire organization. To compete well, business innovations become important and crucial and more so for software industries. With prevalent trends of big data, cloud and cyber security, there are exciting days ahead. Opportunities and innovations are being predicted and by iterations, they can be projected.Design/methodology/approachThe ways in which businesses innovate and implement new ideas are changing. Historically, innovation has commonly been practiced using a “closed innovation” model, particularly with regard to new technology and research and development. It adopts disruptive technologies like big data, cloud computing, cyber securities, etc., and new models of engagements. It sectors business turnaround in sentiment and upbeat mood.FindingsThis paper has looked at the business innovation in Indian software industries’ success in the global information technology industry from a new perspective. India’s software services industry has helped develop a huge talent pool that can write the most complex software. Sales and distribution is no longer a problem because the internet allows you to serve a global market.Originality/valueThis paper, by adopting an analytical and descriptive research method, aims to explore and understand business innovation in software industries. The two studied cases reflect and help to discern how the firms are developing capabilities and reflect how they have evolved over a period, primarily through business and incremental innovations. The advantage of focusing on software products first is that unlike many other product categories, the upfront investments are much more manageable, and we already have the talent base and skills to get going.
A critique of normative commitment in management research
Authors: Jaros Stephen 
Published: March 2017

PurposeThe purpose of this paper was to critically evaluate the existing conception of normative commitment (NC; Meyer and Parfyonova, 2010) as having “two faces”, indebted obligation and moral duty. This paper proposes that NC should be unidimensional, and based on moral content.Design/methodology/approachReview and reevaluation of empirical research into NC and its fit with Meyer and Parfyonova's theory were conducted.FindingsFirst, existing empirical research is inconsistent with Meyer/Parfyonova's theory of NC, as is their proposed motivational bases for NC having two dimensions.Research limitations/implicationsAn important limitation is that NC is likely a culture-specific concept, so cross-cultural research will be essential to fully develop a universally valid concept of morals-based work commitment. A key implication is that despite the lack of construct validity of the currently used NC construct, morals-based commitment is surely a workplace phenomenon; meaning that steps should be taken to rehabilitate the construct, so it can be investigated in substantive research. Therefore, proposals for developing a unidimensional concept of NC that comports with morals-based forms of organizational attachment are developed.Practical implicationsBecause of the lack of validity of the currently used NC concept, managers are advised to not rely on research using this concept to manage their employee's commitment, organizational citizenship behavior (OCB) or withdrawal behavior.Practical implicationsOrganizational members often invest their actions at work with moral meaning. Explicating that meaning via a valid concept of NC could help management researchers understand employee support or lack of support for social responsibility initiatives.Originality/valueNC is a key construct in the work commitment literature. This paper shows that the currently utilized construct is largely invalid, and develops steps to be taken to develop a valid concept of morals-based work commitment.
Why is organizing human resource development so problematic?
Authors: Poell Rob F. , Van Der Krogt Ferd 
Published: March 2017

PurposeHuman resource development (HRD) is an important field within management. Developing employees is often regarded as an instrument to improve the internal labor market and support organizational change. Organizing HRD to these ends, however, is frequently a problematic affair, in terms of training effectiveness, participant motivation and added value. This study, which consists of two parts, aims to investigate the question of why this is the case. In this second part, two specific aspects of the learning-network theory are elaborated: multiple experiences in organizations forming the basis of employee learning and development, and different actor strategies for organizing HRD.Design/methodology/approachThe paper presents a conceptual framework to argue that one of the main reasons why organizing HRD is problematic lies in the limited and one-sided conceptualization of organizing HRD that is often used.FindingsOrganizing HRD is mostly viewed as designing training courses and instruction sessions for employees; it is also predominantly understood as a tool of management. The paper proposes a network perspective on organizing HRD, which is better able to guide organizational actors than other approaches can, by taking into account a broader set of HRD practices and viewing employees (besides managers) as key stakeholders.Originality/valueThe study argues that organizing HRD needs to take into account learning experiences that employees can gain from participating in work and career development as well (besides formal training); moreover, that employees’ HRD strategies are at least as important as those used by line managers and HR practitioners.
Plasma exchange successfully treated macrophage activation syndrome in rheumatoid factor‐positive polyarticular juvenile idiopathic arthritis with co‐existing pneumonia
Authors: Shi Lianjie , Hu Fanlei , Xu Chuanhui , Zhu Huaqun , Qie Di , Yuan Chuanjie , Tao Yuhong , Liu Hanmin 
Published: March 2017

AbstractMacrophage activation syndrome (MAS) is one of the serious complications associated with rheumatic diseases, especially systemic juvenile idiopathic arthritis (sJIA). Here we describe a 9‐year‐old girl with rheumatoid factor (RF)‐positive polyarticular JIA, not sJIA, combined with pneumonia who was successfully treated by plasma exchange. She was diagnosed with RF‐positive polyarticular JIA based on positive RF and multiple joint swelling and tenderness 3 years ago. She was admitted in our hospital with myalgia for 2 days and a high fever for half a day. Physical examination revealed relapsing joints symptoms and rough breathing sounds of lungs. The laboratory examination showed increased liver enzymes, elevated serum ferritin and procalcitonin (PCT), decreased percentage of nature killer (NK) cells and fibrinogen, and activated macrophage phagocytosing hematopoietic elements in bone marrow. The elevated PCT and chest computed tomography scan confirmed she also had pneumonia. Intravenous methylprednisolone and oral cyclosporine A followed by intravenous immunoglobulin were added on the basis of antibiotics therapy, but clinical symptoms and laboratory findings did not improve. Finally, we changed to plasma exchange once every other day for a total of three times. Within 1 week, the girl recovered from the MAS completely.
Changes in expression of theCD200 tolerance‐signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis
Authors: Clark David A. , Dmetrichuk Jennifer M. , McCready Elizabeth , Dhesy‐Thind Sukhbinder , Arredondo Jorge L. 
Published: March 2017

ProblemExpression ofCD200 at the feto‐maternal interface is associated with successful murine and human pregnancy.CD200 binding toCD200 receptors on lymphomyeloid cells suppresses inflammation and induces Tregs.CD200 receptors are also expressed on mouse and human placental trophoblast cells. What is the expression ofCD200 andCD200R in human missed abortions which have preserved Treg levels and in chronic histiocytic intervillositis (CHI) where maternal inflammatory cells causeIUGR?MethodsImmunohistiochemistry forCD200,CD200R, and Ki67 using human placental sections from missed abortions, term placenta, andCHI.PCRtesting was done for trisomy in missed abortion.ResultsCD200 andCD200R were expressed by human villus trophoblasts from 2 weeks post‐implantation to term. Cytotrophoblast proliferation (Ki‐67+count) decreased at term. In first trimester missed abortion cases,CD200>CD200R villus trophoblasts accompanied missed abortion of non‐trisomic male fetuses.CD200 and Ki67+trophoblast proliferation was preserved inCHIwith maternal inflammatory cell infiltration butCD200R was greatly decreased.ConclusionResidualCD200 activity may prevent completion of abortions via induction of Treg cells. InCHI, infiltrating maternal effector T cells may block Treg induction. An autocrine role forCD200‐CD200R interaction versus inhibition of solubleCD200 by solubleCD200R is discussed.
Reviewer Acknowledgements
Authors: Smith Robert 
Published: March 2017

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 5, Number 4Anne M. Hornak, Central Michigan University, USACarmen Pérez-Sabater, Universitat Poltècnica de València, SpainChosang Tendhar, Baylor College of Medicine, USACynthia M. Compton, Wingate University, USADamodar Khanal, The University of Manchester, UKErica D. Shifflet-Chila, Michigan State University, USAErkal Arslanoğlu, Sinop University, TurkeyFethi Arslan, Mersin University, TurkeyGobinder Gill, Birmingham Metropolitan College, UKHalis Sakiz, Mardin Artuklu University, TurkeyHyesoo Yoo, Virginia Tech., USAIbrahim Can, Gumushane University, TurkeyIntakhab Khan, King Abdulaziz University, Saudi ArabiaJosé D Badia, University of Valencia, SpainLeila Youssef, Arab Open University, LebanonLisa Marie Portugal, Grand Canyon University, USALorna T. Enerva, Polytechnic University of the Philippines, PhilippinesMahmoud Radwan, Tanta University, EgyptMarcie Zaharee, The MITRE Corporation, USAMarieke van der Schaaf, Utrecht University, The NetherlandsMehmet Inan, Marmara University, TurkeyMin Gui, Wuhan University, ChinaMukadder Baran, Hakkari University, TurkeyMürşet Çakmak, Mardin Artuklu University, TurkeyMustafa Çakır, Marmara Üniversity, TurkeyNele Kampa, Leibniz-Institute for Science and Mathematics Education (IPN), GermanyNiveen M. Zayed, MENA College of Management, JordanOnder Daglioglu, Gaziantep University, TurkeyÖzgür Bostanci, Ondokuz Mayis University, TurkeyRecep Aslaner, Inonu University, TurkeyRichard Penny, University of Washington Bothell, USASandra Kaplan, Rutgers, The State University of New Jersey, USAŞenay Koparan, Uludağ University, TurkeyShengnan Liu, Ocean University of China, ChinaSimona Savelli, Università degli Studi Guglielmo Marconi, ItalyThomas K. F. Chiu, The University of Hong Kong, Hong KongTurhan Toros, Mersin Üniversitesi, TurkeyYalçın Dilekli, Aksaray University, TurkeyYerlan Seisenbekov, Kazakh National Pedagogical University, KazakhstanZachary Wahl-Alexander, Northern Illinois University, USAZeki Coşkuner, Fırat University, Turkey Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://jets.redfame.com
Phase I Dose-Escalation Study of Taselisib, an Oral PI3K Inhibitor, in Patients with Advanced Solid Tumors
Authors: Juric Dejan , Krop Ian , Ramanathan Ramesh K. , Wilson Timothy R. , Ware Joseph A. , Sanabria Bohorquez Sandra M. , Savage Heidi M. , Sampath Deepak , Salphati Laurent , Lin Ray S. , Jin Huan , Parmar Hema , Hsu Jerry Y. , Von Hoff Daniel D. , Baselga José 
Published: March 2017

AbstractTaselisib is a potent and selective tumor growth inhibitor through PI3K pathway suppression. Thirty-four patients with locally advanced or metastatic solid tumors were treated (phase I study, modified 3+3 dose escalation; 5 cohorts; 3–16 mg taselisib once-daily capsule). Taselisib pharmacokinetics were dose-proportional; mean half-life was 40 hours. Frequent dose-dependent, treatment-related adverse events included diarrhea, hyperglycemia, decreased appetite, nausea, rash, stomatitis, and vomiting. At 12 and 16 mg dose levels, dose-limiting toxicities (DLT) were observed, with an accumulation of higher-grade adverse events after the cycle 1 DLT assessment window. Pharmacodynamic findings showed pathway inhibition at ≥3 mg in patient tumor samples, consistent with preclinical PIK3CA-mutant tumor xenograft models. Confirmed response rate was 36% for PIK3CA-mutant tumor patients with measurable disease [5/14: 4 breast cancer (3 patients at 12 mg); 1 non–small cell lung cancer], where responses started at 3 mg, and 0% in patients with tumors without known PIK3CA hotspot mutations (0/15).Significance: Preliminary data consistent with preclinical data indicate increased antitumor activity of taselisib in patients with PIK3CA-mutant tumors (in comparison with patients with tumors without known activating PIK3CA hotspot mutations) starting at the lowest dose tested of 3 mg, thereby supporting higher potency for taselisib against PIK3CA-mutant tumors. Cancer Discov; 7(7); 704–15. ©2017 AACR.See related commentary by Rodon and Tabernero, p. 666.This article is highlighted in the In This Issue feature, p. 653
Revision of the Ephippiochthonius complex in the Iberian Peninsula, Balearic Islands and Macaronesia, with proposed changes to the status of the Chthonius subgenera (Pseudoscorpiones, Chthoniidae)
Authors: ZARAGOZA JUAN A. 
Published: March 2017

A taxonomic revision of the subgenus Chthonius (Ephippiochthonius) in the Iberian Peninsula, Balearic Islands and Macaronesia is presented. New and previously insufficiently studied characteristics are shown to be taxonomically useful, such as the chelal lyrifissures patterns, chaetotaxy and condylar complex. Three taxa previously treated as subgenera of Chthonius are here raised to generic rank: Ephippiochthonius n. stat., Globochthonius n. stat., and Hesperochthonius n. stat. Two new genera are described: Cantabrochthonius n. gen. and Occidenchthonius n. gen. Thirty-five new species are described: Ephippiochthonius aini n. sp., E. andalucia n. sp., E. aurouxi n. sp., E. benimaquia n. sp., E. caceresi n. sp., E. castellonensis n. sp., E. comasi n. sp., E. fadriquei n. sp., E. galcerani n. sp., E. gonzalezi n. sp., E. henderickxi n. sp., E. ibiza n. sp., E. masoae n. sp., E. portugalensis n. sp., E. riberai n. sp., E. serengei n. sp., E. sevai n. sp., E. tarraconensis n. sp., E. vicenae n. sp., E. zaballosi n. sp., Occidenchthonius anae n. sp., O. beieri n. sp., O. ebo n. sp., O. felgueraorum n. sp., O. gardinii n. sp., O. hoerwegi n. sp., O. lencinai n. sp., O. mahnerti n. sp., O. mateui n. sp., O. montagudi n. sp., O. murcia n. sp., O. oromii n. sp., O. ortunoi n. sp., O. riopar n. sp. and O. serranoi n. sp. A neotype is designated for Ephippiochthonius catalonicus (Beier, 1939), n. comb. As result of the changes in generic rank, 45 new combinations for species are proposed.
Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway
Authors: Zhao Zhi-Min , Liu Hong-Liang , Sun Xin , Guo Tao , Shen Li , Tao Yan-Yan , Liu Cheng-Hai 
Published: March 2017

Levistilide A (C24H28O4, molecular weight = 380.48) derived from Angelica sinensis (Danggui) has been reported to inhibit hepatic stellate cell proliferation. This study investigated the effects of levistilide A on liver fibrosis relating to angiogenesis, particularly on the characteristic change in liver sinusoidal endothelial cells. LX-2 cells were activated by TGF-β1, and the human hepatic sinusoidal endothelial cells (HHSECs) were induced by endothelial cell growth supplement. Cell viability was detected using a methylthiazoldiphenyl–tetrazolium bromide assay; F-actin was visualized through the fluorescence probe method; cell proliferation was examined using the EdU kit; antiangiogenesis activity was assessed using the tube formation assay and transgenic zebrafish model. To verify the results in vivo, rats were subcutaneously injected with CCl4 twice a week for six weeks to duplicate the liver fibrosis model and then treated with 10 mL/kg of normal saline, 4 mg/kg of sorafenib, and 3 and 6 mg/kg of levistilide A for three weeks from the fourth week. Collagen deposition was detected through Sirius Red staining; liver microvasculature was examined through vWF labeling and X-ray 2D imaging; sinusoidal fenestrations were observed through scanning electron microscopy; collagen I, α-SMA, CD31, vascular endothelial growth factor (VEGF), and VEGF-R2 were detected through Western blotting. Our results indicated that levistilide A attenuated LX-2 cell activation and HHSEC proliferation. The ability of HHSECs to form tubelike structures in Matrigel was inhibited, and the number of functional vessels in transgenic zebrafish decreased. In in vivo experiments, levistilide A reduced collagen deposition and the number of new microvessels; ameliorated sinusoid capillarization; and downregulated the expression of CD31, VEGF, and VEGF-R2. These findings suggest that levistilide A can inhibit liver fibrosis through antiangiogenesis by alleviating sinusoid capillarization via the VEGF signaling pathway. Impact statement Levistilide A has been reported to inhibit hepatic stellate cell (HSC) proliferation. In this study, we further investigated the mechanisms of levistilide A on liver fibrosis relating to angiogenesis, particularly on the characteristic change in liver sinusoidal endothelial cells. The cell models of HSC and liver sinusoidal endothelial cell and CCl4 induced liver fibrosis model were used. These results suggest that levistilide A can inhibit liver fibrosis through antiangiogenesis by alleviating sinusoid capillarization via the vascular endothelial growth factor signaling pathway. The effect of levistilide A on liver fibrosis was confirmed, and its detailed mechanism was also discussed. These findings suggest that levistilide A may be a great potential drug for treating liver fibrosis through antiangiogenesis, and this effect will be verified in other fibrotic animal model studies or by clinical trials.