bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostaglandin E2 inhibits matrix mineralization by human bone marrow stromal cell-derived osteoblasts via Epac-dependent cAMP signaling
Authors: Mirsaidi Ali , Tiaden André N. , Richards Peter J. 
Published: May 2017

AbstractThe osteoinductive properties of prostaglandin E2 (PGE2) and its signaling pathways have led to suggestions that it may serve as a potential therapeutic strategy for bone loss. However, the prominence of PGE2 as an inducer of bone formation is attributed primarily to findings from studies using rodent models. In the current study, we investigated the effects of PGE2 on human bone marrow stromal cell (hBMSC) lineage commitment and determined its mode of action. We demonstrated that PGE2 treatment of hBMSCs significantly altered the expression profile of several genes associated with osteoblast differentiation (RUNX2 and ALP) and maturation (BGLAP and MGP). This was attributed to the activation of specific PGE2 receptors, and was associated with increases in cAMP production and sustained AKT phosphorylation. Pharmacological inhibition of exchange protein directly activated by cAMP (Epac), but not protein kinase A (PKA), recovered the mineralization functions of hBMSC-derived osteoblasts treated with PGE2 and restored AKT phosphorylation, along with the expression levels of RUNX2, ALP, BGLAP and MGP. Our findings therefore provide insights into how PGE2 influences hBMSC-mediated matrix mineralization, and should be taken into account when evaluating the role of PGE2 in human bone metabolism.
Modern pollen data from the Canadian Arctic, 1972–1973
Authors: Nichols Harvey , Stolze Susann 
Published: May 2017

AbstractThis data descriptor reports results of a 1972–73 baseline study of modern pollen deposition in the Canadian Arctic to originally aid interpretation of Holocene pollen diagrams from that region, especially focussed on the arctic tree-line. The data set is geographically unique due to its extent, and allows the assessment of the effects of modern climate change on northern ecosystems, including fluctuations of the a arctic tree-line. Repeated sampling was conducted along an interior transect at 29 sites from the Boreal Forest to the High Arctic, with five additional coastal sites covering a total distance of 3,200 km. Static pollen samplers captured both local pollen and long-distance pollen wind-blown from the Boreal Forest. Moss and lichen polsters provided multi-year pollen fallout to assess the effectiveness of the static pollen samplers. The local vegetation was recorded at each site. This descriptor provides information on data archived at the World Data Center PANGAEA, which includes spreadsheets detailing site and sample information as well as raw and processed pollen data obtained on over 500 samples.
A resource on latitudinal and altitudinal clines of ecologically relevant phenotypes of the Indian Drosophila
Authors: Rajpurohit Subhash , Zhao Xiaqing , Schmidt Paul S. 
Published: May 2017

AbstractThe unique geography of the Indian subcontinent has provided diverse natural environments for a variety of organisms. In this region, many ecological indices such as temperature and humidity vary predictably as a function of both latitude and altitude; these environmental parameters significantly affect fundamental dynamics of natural populations. Indian drosophilids are diverse in their geographic distribution and climate tolerance, possibly as a result of climatic adaptation. These associations with environmental parameters are further reflected in a large number of clines that have been reported for various fitness traits along these geographical ranges. This unique amalgamation of environmental variability and genetic diversity make the subcontinent an ecological laboratory for studying evolution in action. We assembled data collected over the last 20 years on the geographical clines for various phenotypic traits in several species of drosophilids and present a web-resource on Indian-Drosophila(http://www.indian-drosophila.org/). The clinal data on ecologically relevant phenotypes of Indian drosophilids will be useful in addressing questions related to future challenges in biodiversity and ecosystems in this region.
First Characterisation of Volatile Organic Compounds Emitted by Banana Plants
Authors: Berhal Chadi , De Clerck Caroline , Fauconnier Marie-Laure , Levicek Carolina , Boullis Antoine , Kaddes Amine , Jijakli Haïssam M. , Verheggen François , Massart Sébastien 
Published: May 2017

AbstractBanana (Musa sp.) ranks fourth in term of worldwide fruit production, and has economical and nutritional key values. The Cavendish cultivars correspond to more than 90% of the production of dessert banana while cooking cultivars are widely consumed locally around the banana belt production area. Many plants, if not all, produce Volatile Organic Compounds (VOCs) as a means of communication with their environment. Although flower and fruit VOCs have been studied for banana, the VOCs produced by the plant have never been identified despite their importance in plant health and development. A volatile collection methodology was optimized to improve the sensitivity and reproducibility of VOCs analysis from banana plants. We have identified 11 VOCs for the Cavendish, mainly (E,E)-α-farnesene (87.90 ± 11.28 ng/μl), methyl salicylate (33.82 ± 14.29) and 6-methyl-5-hepten-2-one (29.60 ± 11.66), and 14 VOCs for the Pacific Plantain cultivar, mainly (Z,E)-α-farnesene (799.64 ± 503.15), (E,E)-α-farnesene (571.24 ± 381.70) and (E) β ocimene (241.76 ± 158.49). This exploratory study paves the way for an in-depth characterisation of VOCs emitted by Musa plants.
Auditory Processing of Older Adults With Probable Mild Cognitive Impairment
Authors: Edwards Jerri D. , Lister Jennifer J. , Elias Maya N. , Tetlow Amber M. , Sardina Angela L. , Sadeq Nasreen A. , Brandino Amanda D. , Harrison Bush Aryn L. 
Published: May 2017

PurposeStudies suggest that deficits in auditory processing predict cognitive decline and dementia, but those studies included limited measures of auditory processing. The purpose of this study was to compare older adults with and without probable mild cognitive impairment (MCI) across two domains of auditory processing (auditory performance in competing acoustic signals and temporal aspects of audition).MethodThe Montreal Cognitive Assessment (Nasreddine et al., 2005) was used to classify participants as with or without probable MCI. In this cross-sectional study, participants (n= 79) completed 4 measures of auditory processing: Synthetic Sentence Identification with Ipsilateral Competing Message (Gates, Beiser, Rees, D'Agostino, & Wolf, 2002), Dichotic Sentence Identification (Fifer, Jerger, Berlin, Tobey, & Campbell, 1983), Adaptive Tests of Temporal Resolution (ATTR; Lister & Roberts, 2006; across-channel and within-channel subtests), and time-compressed speech (Wilson, 1993; Wilson, Preece, Salamon, Sperry, & Bornstein, 1994). Audiometry was also conducted.ResultsThose with probable MCI had significantly poorer performance than those without MCI on Synthetic Sentence Identification with Ipsilateral Competing Message, Dichotic Sentence Identification, and the ATTR within-channel subtest. No group differences were found for time-compressed speech, ATTR across-channel, or audiometric measures.ConclusionsOlder adults with cognitive impairment not only have difficulty with competing acoustic signals but may also show poor temporal processing. The profile of auditory processing deficits among older adults with cognitive impairment may include multiple domains.
Tunable linearity enhancement for 180 nm complementary metal–oxide–semiconductor LNA with active feedback
Authors: Khaleel Farooq Abdulghafoor , Abbas Mohammed Nadhim 
Published: May 2017

The authors present a tunable linearity improvement of complementary metal–oxide–semiconductor low‐noise amplifier (LNA) using derivative superposition method and an active MOS field‐effect transistor feedback transistor. The proposed LNA achieves a third‐order input intercept point (IIP3) of 21 dBm, 9.43 dB gain, and 2.4 dB minimum noise figure. In addition, the proposed LNA method dissipates 28.4 mW supplied from 1.8 V voltage source. The proposed LNA provides flexibility to tune the power dissipation and linearity according to the work environment. They perform the simulation with keysight ADS2016.01 software utilising 180 nm TSMC model files.
Distribution of long-period comets: comparison between simulations and observations
Authors: Fouchard M. , Rickman H. , Froeschlé Ch. , Valsecchi G. B. 
Published: May 2017

Aims. This paper is devoted to a comparison between observations and simulations of the so-called Oort spike formed by the “new” observable long-period comets.
Methods. The synthetic distributions of observable comets come from the propagation of a huge sample of objects during the age of the solar system that were initially in a proto-Oort cloud, which was flattened around the ecliptic and had perihelia in the region of Uranus and Neptune. For the known new long-period comets, two samples were used, one that is assumed to be complete, and the comets of the other exclusively come from the Warsaw catalog of comets. The original orbital energy of the comets in this catalog is more reliable.
Results. Considering comets with a perihelion distance smaller than 4 AU, for which one of our samples of known comets can be assumed to be complete, the comparison shows small but significant differences in the orbital energy distribution and in the proportion of retrograde comets. When we extend the limiting perihelion distance to 10 AU, the observed samples are obviously strongly incomplete. The synthetic distribution showsthat the number of observable comets per year and per perihelion distance unit is ∝q1.09 for q< 4 AU and ∝q2.13 for 6 <q< 10 AU. The increase for q> 6 AU comes from comets that were already within the Jupiter-Saturn barrier (q< 15 AU) at their previous perihelion passage (which we call creepers and Kaib and Quinn creepers), with original semi-major axes generally smaller than 20 000 AU.
Conclusions. To explain the small but significant differences between our synthetic sample and the known comets for a perihelion distance smaller than 4 AU, different hypotheses are proposed: a still erroneous value of the original orbital energy in the observed sample, a higher density of low-mass stars in the actual solar neighborhood, a ninth planet, and obviously the initial population of objects from which the synthetic distributions are derived.
Early Postoperative Endoscopy for Evaluation of the Anastomosis after Esophageal Reconstruction
Authors: Lin Tzu-Hsin , Huang Pei-Ming 
Published: May 2017

Background Anastomotic leaks significantly affect hospital stay after esophageal surgery. Here, we investigated the efficacy of early endoscopy for predicting anastomotic healing and leaks after esophageal reconstruction.
Methods A total of 65 consecutive esophageal cancer patients treated by cervical esophagogastrostomy underwent routine endoscopy between postoperative days 5 and 7. The anastomosis was scored for the degree of ischemia, stenosis, and torsion of the anastomotic axis. Independent associations between ischemia, stenosis, and torsion of the proximal esophagus and the risk of the anastomotic leak were examined using Spearman's rank correlation method.
Results Assessment of the degree of mucosal ischemia in 65 patients shows well healing in 35, patch ischemia in 20, diffuse ischemia in 10, no necrosis in any patient. Stenosis was classified as 0 to 10% in 40 patients, 11 to 20% in 12, 21 to 80% in 11, and 81 to 100% in 2. The degree of torsion of the anastomotic axis was classified as 0 to 10 degrees in 52 patients, 11 to 90 degrees in 8, and 91 to 180 degrees in 5. With rising endoscopy scores, there was an increase in risk for leaks (score > 4.5, sensitivity 100%, and specificity 83.8%).
Conclusions Early postoperative endoscopy facilitates the management of esophagogastrostomy anastomosis to predict leaks.
Significance of Scapholunate Gap Width as Measured by Probe from Midcarpal
Authors: Erne Holger , Strobl Ute , Unglaub Frank , Spies Christian , Löw Steffen 
Published: May 2017

Background Geissler's classification is widely accepted in arthroscopic diagnostics of scapholunate (SL) ligament injury. Thereby, probe insertion into the SL gap from the midcarpal would indicate treatment necessity in patients with SL tear as seen from radiocarpal view.
Purpose In this review, the SL gap width, examined by the probe from midcarpal, was arthroscopically assessed in patients with intact SL ligaments, who were treated for ulnar impaction syndrome. The review examined how often lax SL joints can be found in patients with no complaints with respect to the SL ligaments and in which the SL ligaments were proven to be intact from radiocarpal view. We suspected that probe insertion, as an indicator for a lax joint, does not affect the outcome in ulnar impaction treatment.
Patients and Methods A total of 32 patients with clinically diagnosed ulnar impaction syndrome were arthroscopically treated by central resection and debridement of the triangular fibrocartilage; 8 patients underwent concurrent ulnar shortening, and 4 of them finally hardware removal. All patients were examined preoperatively as well as after 3, 6, and 12 months following arthroscopy, respectively, after ulnar shortening or hardware removal.
Results In 14 patients, the probe could not, in 18 patients, the probe could be inserted into the SL gap. There was neither any significant difference in the improvement of pain, grip strength, Krimmer, or DASH score, nor for any of the radiographic angles between the two groups.
Conclusion Laxity of the SL ligament allows the probe to be inserted into the SL gap from midcarpal in some patients. This finding, therefore, does not necessarily imply the necessity of treatment when there is partial rupture seen from radiocarpal view.
Level of Evidence Level III, case–control study.
Low Fibrinogen Is Associated with Increased Bleeding-Related Re-exploration after Cardiac Surgery
Authors: Essa Yasin , Zeynalov Natig , Sandhaus Tim , Hofmann Michael , Lehmann Thomas , Doenst Torsten 
Published: May 2017

Background Re-exploration after cardiac surgery remains a relatively frequent complication associated with adverse effects on outcome. We aimed to identify risk factors for re-exploration.
Methods We retrospectively reviewed 2,403 patients having undergone cardiac surgical procedure between January 2013 and December 2014. Re-exploration was required in 114 patients (4.7%). Patients with oral anticoagulation, infective endocarditis, or a clearly identified bleeding source were excluded. Therefore, 42 patients remained for analysis. A matched cohort was selected for age, sex, ejection fraction, creatinine, and procedure out of the non–re-explored patients.
Results Demographic data were similar in both groups, except for a higher prevalence of diabetes (45 vs. 21%; p = 0.036) in the non–re-explored patients. Surgery was elective in two-thirds and preoperative plasma fibrinogen concentration was lower in patients requiring re-exploration (2.8 ± 0.9 vs. 3.6 ± 0.9 g/L; p = 0.002). During the initial operation, re-explored patients received more packed red blood cells (1.5 ± 3 vs. 0 ± 1 units; p < 0.001), Postoperatively, re-explored patients had higher lactate levels (1.7 ± 1.4 vs. 1.3 ± 0.6 mmol/L, p = 0.044), more chest tube drainage (1,245 ± 948 vs. 685 ± 413 mL; p < 0.001), higher hospital mortality (19 vs. 7%; p = 0.19), and longer intensive care unit (ICU) stays (8 ± 8 vs. 4 ± 7 days; p = 0.010). In addition, more fibrinogen was administrated during the initial surgery. Plasma fibrinogen concentration upon arrival at the ICU was lower in patients requiring re-exploration (2 ± 0.6 vs. 2.7 ± 0.7 g; p < 0.001). Multivariable linear regression analysis identified fibrinogen upon arrival at the ICU as an independent predictor of postoperative bleeding.
Conclusion Cardiac surgery patients with low perioperative plasma fibrinogen concentration appear to be more susceptible to bleeding and re-exploration. Re-exploration in this group of patients is associated with increased morbidity and mortality.
Stationärer Therapieerfolg bei Patientinnen mit Anorexia Nervosa und komorbiden Persönlichkeitsstörungen
Authors: Link Timo , Beermann Ursula , Mestel Robert , Gander Manuela 
Published: May 2017

Zusammenfassung
Einleitung Persönlichkeitsstörungen (PS) stellen häufige komorbide Erkrankungen bei Patientinnen mit Anorexia Nervosa (AN) dar. Die neusten internationalen Forschungsergebnisse deuten darauf hin, dass diese mit einem schlechteren Genesungs- und Therapieverlauf gerade bei AN in Zusammenhang stehen. Bisherige Studien zu diesem Thema differenzierten bislang jedoch nicht zwischen Personen unterschiedlicher Altersgruppen.
Fragestellungen Aus diesem Grund widmet sich die vorliegende Untersuchung (1) der Prävalenz von komorbiden PS, (2) der Therapieabbruchsrate sowie (3) der Gewichtszunahme während des Therapieverlaufs bei weiblichen stationären Patientinnen mit AN für 3 gesonderte Alterskategorien (17–24; 25–34; 35–65 Jahre).
Material & Methoden Die Stichprobe umfasste 331 stationäre Patientinnen mit AN an der Helios Klinik in Bad Grönenbach in Deutschland. Zu Beginn und am Ende der Therapie wurde das Gewicht gemessen sowie eine Testbatterie bestehend aus der psychotherapeutisch-medizinischen Basisdokumentation und dem Eating Disorders Inventory-2 bearbeitet. Die Diagnosen von Persönlichkeitsstörungen wurden durch geschulte Therapeuten, unter den Richtlinien der kategorisierten Störungsbilder der ICD-10, erhoben.
Ergebnisse Patientinnen mit AN wiesen insgesamt eine Prävalenz von 34% für eine oder mehrere komorbide PS auf. Interessant war, dass Patientinnen zwischen 17 und 24 Jahren mit 22% eine deutlich geringere Rate an PS zeigten als jene zwischen 25–34 Jahren (42%) sowie jene mit 35–65 Jahren (41%). Des Weiteren konnten wir zeigen, dass Patientinnen eher eine Therapie abbrachen, wenn sie jünger waren und eine komorbide PS aufwiesen. Während der Therapie nahmen die jüngsten AN Patientinnen ohne PS am meisten zu und mit zunehmendem Alter sank diese Differenz graduell ab. Dieses Muster konnte bei Patientinnen mit einer komorbiden PS nicht mehr beobachtet werden, da bei diesen die höchste Gewichtszunahme zwischen 25 und 34 Jahren zu verzeichnen war.
Schlussfolgerungen Unsere Ergebnisse unterstützen die Hypothese, dass komorbide PS möglicherweise auch einen schlechten Prognosefaktor darstellen können. Zukünftige Studien, welche sich der dimensionalen Einstufung von Persönlichkeitspathologien bedienen und weitere Faktoren wie bspw. das Ausmaß der sozialen Unterstützung miteinbeziehen, stellen eine wichtige Grundlage für störungsspezifische Interventionen für diese Patientengruppen dar.
Stimmlich enkodierte emotionale Erregung (Voice Stress) und Posttraumatische Reifung sowie Partnerschaftszufriedenheit bei Partnern von Brustkrebspatientinnen im Kontext der sozialen Unterstützung
Authors: Zimmermann Tanja , Krüger Jan , Weusthoff Sarah 
Published: May 2017

Zusammenfassung
Einleitung Eine Brustkrebserkrankung geht mit erheblichen psychosozialen Belastungen für die Patientin und ihren Partner einher. Positive intradyadische Kommunikation und gegenseitige soziale Unterstützung wirken protektiv gegenüber diesen Belastungen. Individuelle emotionale Erregung gemessen über die Sprachgrundfrequenz (f0) gilt während partnerschaftlicher Interaktionen als wichtiger Aspekt des gegenseitigen Unterstützungsverhaltens und kann über die Sprachgrundfrequenz (f0-range) objektiv gemessen werden.
Material & Methoden N=44 Paare führten siebenminütige Gespräche, bei denen der Mann als Sprecher seine Belastungen bezüglich der Krebserkrankung der Frau äußerte, während die Frau in der Zuhörerrolle Unterstützung bieten sollte. Mithilfe eines Akteur-Partner-Interdependenz-Modells (APIM) wurde die f0 beider Partner während der partnerschaftlichen Interaktion und ihr Zusammenhang mit dem Ausmaß an posttraumatischer Reifung (PTR) und Partnerschaftsqualität untersucht.
Ergebnisse Eine größere PTR hing mit einer höheren eigenen f0 im Paargespräch bei den Männern zusammen (Akteur-Effekt) sowie tendenziell mit der f0 der Frau (Partner-Effekt). Es konnten keine Akteur- oder Partnereffekte bei den Frauen gefunden werden. Keine Effekte zeigten sich für Partnerschaftsqualität und f0.
Diskussion Im Rahmen partnerschaftlicher Unterstützung scheint eine erhöhte emotionale Erregung f0 in Verbindung mit positiven psychologischen Faktoren zu stehen. Die f0 im Kontext der sozialen Unterstützung könnte mit einer positiven Selbstwirksamkeitserwartung zusammen hängen, die sich förderlich auf PTR auswirken und dem Sprecher Souveränität im emotionalen Ausdruck verleihen könnte. Diese Souveränität könnte sich wiederum in einer höheren Involviertheit und somit höheren f0 – Werten ausdrücken. Eine weitere Überprüfung dieser Ergebnisse ist erforderlich.
Contrast-Enhanced Ultrasound in the Follow-Up of Endoleaks after Endovascular Aortic Repair (EVAR)
Authors: Rübenthaler Johannes , Zimmermann Hanna , Armbruster Marco , Müller-Peltzer Katharina , Bogner Florian , Reiser Maximilian , Clevert Dirk-André 
Published: May 2017

AbstractEndovascular aortic repair (EVAR) has become established in the treatment of abdominal aortic aneurysms and shows potential benefits such as a low perioperative morbidity and a short hospitalization duration. The follow-up after EVAR primarily consists of lifelong postinterventional imaging of the aneurysm size in order to detect complications such as endoleaks or stent dislocation. Computed tomography angiography, an imaging modality that uses ionizing radiation and that relies on a contrast medium which is dependent on thyroid and renal function, is widely used for follow-up. Meanwhile, contrast-enhanced ultrasound (CEUS) has been established as a viable, fast and cost-effective imaging alternative for the follow-up and the detection of endoleaks after EVAR with the additional benefit of being a real-time non-ionizing radiation examination and having comparable or even superior diagnostic performance. This review describes the use of CEUS for follow-up after EVAR and describes the most common pathologies.