bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blending design of composite laminated structure with panel permutation sequence
Authors: Jin P. , Wang Y. , Zhong X. , Yang J. , Sun Z. 
Published: January 2018

ABSTRACTPreviously, the concept of Ply Drop Sequence (PDS) is introduced by the authors for the designing of composite laminated structures with multiple regions. Compared to deleting a contiguous innermost/outermost plies in the classical guide-based blending, using PDS is more flexible than dropping plies between adjacent regions. In this article, a new blending model called the Permutation for Panel Sequence (PPS) blending model is proposed to correct the problem of repeated searching of discrete points in the design space for the previous PDS blending model. The proposed method is also applied to an 18-panel horseshoe benchmark problem. The results demonstrate that the useful searching points in the PPS method are less than those in the PDS method when the number of the panels is less than the number of plies in the guide laminate, and the PPS method obtains a faster convergence speed compared with the PDS method.
Bronislaw Malinowski, “Indirect Rule,” and the Colonial Politics of Functionalist Anthropology, ca. 1925–1940
Authors: Foks Freddy 
Published: January 2018

AbstractFunctionalist anthropology has a contested legacy. Some scholars have praised functionalism as a contributor to the relativizing of civilizations and cultures while others have criticized it as a colonial science smoothing the interwar workings of indirect rule. This article argues that the colonial politics of functionalist anthropology can only be understood against the background of resurgent settler colonialism in British East Africa. Supporters of indirect rule increasingly relied on a language of scientific administration and welfarist policies associated with the League of Nations to bolster their position against the settlers in the 1920s and 1930s. Functionalism offered them some means of support on this count. The functionalists, meanwhile, co-opted the language of indirect rule to pursue their own intra-disciplinary ends. This combination of interests was pragmatic and flexible rather than ossified and ideological, marked more by what both opposed (settler colonialism) than a shared ideal towards which they aspired (indirect rule). Anthropologists and colonial administrators possessed very different ideas of indirect rule, with strikingly different implications for the future of Britain's African Empire.
A Sea of Difference, a History of Gaps: Migrations between Italy and Albania, 1939–1992
Authors: Ballinger Pamela 
Published: January 2018

AbstractThis article examines extended debates after World War II over the repatriation of Italian civilians from Albania, part of the Italian fascist empire from 1939 until 1943. Italy's decolonization, when it is studied at all, usually figures as rapid and non-traumatic, and an inevitable byproduct of Italy's defeat in the war. The tendency to gloss over the complexities of decolonization proves particularly marked in the Albanian case, given the brevity of Italy's formal rule over that country and the overwhelming historiographical focus on the Italian military experience there. In recovering the complex history of Italian and Albanian relations within which negotiations over repatriation occurred, this article demonstrates the prolonged process of imperial repatriation and its consequences for the individuals involved. In some cases, Italian citizens, and their families, only “returned” home to Italy in the 1990s. The repatriation of these “remainders” of empire concerned not only the Italian and Albanian states but also local committees (notably the Circolo Garibaldi) and international organizations, including the United Nations Relief and Rehabilitation Administration and the International Committee of the Red Cross. In recuperating this history, the analysis rejects seeming truisms about the forgotten or repressed memory of Italian colonialism. Drawing upon critical theories of “gaps,” the article addresses the methodological challenges in writing such a history.
Erythromelalgia
Authors: Klein-Weigel Peter Franz , Volz Theresa Sophie , Richter Jutta Gisela 
Published: January 2018

Abstract. Erythromelalgia is a rare syndrome characterized by the intermittent or, less commonly, by the permanent occurrence of extremely painful hyperperfused skin areas mainly located in the distal extremities. Primary erythromelalgia is nowadays considered to be a genetically determined neuropathic disorder affecting SCN9A, SCN10A, and SCN11A coding for NaV1.7, NaV1.8, and NaV1.9 neuronal sodium channels. Secondary forms might be associated with myeloproliferative disorders, connective tissue disease, cancer, infections, and poisoning. Between the pain episodes, the affected skin areas are usually asymptomatic, but there are patients with typical features of acrocyanosis and/or Raynaud’s phenomenon preceding or occurring in between the episodes of erythromelalgia. Diagnosis is made by ascertaining the typical clinical features. Thereafter, the differentiation between primary and secondary forms should be made. Genetic testing is recommended, especially in premature cases and in cases of family clustering in specialized genetic institutions after genetic counselling. Multimodal therapeutic intervention aims toward attenuation of pain and improvement of the patient’s quality of life. For this purpose, a wide variety of nonpharmacological approaches and pharmacological substances for topical and systemic use have been proposed, which are usually applied individually in a step-by-step approach. Prognosis mainly depends on the underlying condition and the ability of the patients and their relatives to cope with the disease. Keywords: Erythromelalgia, erythermalgia, genetic pain syndrome, vascular acrosyndrome, chronic pain syndrome, small fibre polyneuropathy
The fungus that came in from the cold: dry rot’s pre-adapted ability to invade buildings
Authors: Balasundaram S V , Hess J , Durling M B , Moody S C , Thorbek L , Progida C , LaButti K , Aerts A , Barry K , Grigoriev I V , Boddy L , Högberg N , Kauserud H , Eastwood D C , Skrede I 
Published: January 2018

Abstract
Many organisms benefit from being pre-adapted to niches shaped by human activity, and have successfully invaded man-made habitats. One such species is the dry rot fungus Serpula lacrymans, which has a wide distribution in buildings in temperate and boreal regions, where it decomposes coniferous construction wood. Comparative genomic analyses and growth experiments using this species and its wild relatives revealed that S. lacrymans evolved a very effective brown rot decay compared to its wild relatives, enabling an extremely rapid decay in buildings under suitable conditions. Adaptations in intracellular transport machineries promoting hyphal growth, and nutrient and water transport may explain why it is has become a successful invader of timber in houses. Further, we demonstrate that S. lacrymans has poor combative ability in our experimental setup, compared to other brown rot fungi. In sheltered indoor conditions, the dry rot fungus may have limited encounters with other wood decay fungi compared to its wild relatives. Overall, our analyses indicate that the dry rot fungus is an ecological specialist with poor combative ability against other fungi.
Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
Authors: Li Jianshuang , Lu Di , Dou Hong , Liu Huadie , Weaver Kevin , Wang Wenjun , Li Jiada , Yeh Edward T.H. , Williams Bart O. , Zheng Ling , Yang Tao 
Published: January 2018

AbstractThe development, growth, and renewal of skeletal tissues rely on the function of osteochondroprogenitors (OCPs). Protein sumoylation/desumoylation has emerged as a pivotal mechanism for stem cell/progenitor homeostasis, and excessive sumoylation has been associated with cell senescence and tissue aging, but its role in regulating OCP function is unclear. Here we show that postnatal loss of the desumoylase SUMO1/sentrin-specific peptidase 6 (SENP6) causes premature aging. OCP-specific SENP6 knockout mice exhibit smaller skeletons, with elevated apoptosis and cell senescence in OCPs and chondrocytes. In Senp6
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cells, the two most significantly elevated pathways are p53 signaling and senescence-associated secreted phenotypes (SASP), and Trp53 loss partially rescues the skeletal and cellular phenotypes caused by Senp6 loss. Furthermore, SENP6 interacts with, desumoylates, and stabilizes TRIM28, suppressing p53 activity. Our data reveals a crucial role of the SENP6–p53 axis in maintaining OCP homeostasis during skeletal development.
Ancient environmental DNA reveals shifts in dominant mutualisms during the late Quaternary
Authors: Zobel Martin , Davison John , Edwards Mary E. , Brochmann Christian , Coissac Eric , Taberlet Pierre , Willerslev Eske , Moora Mari 
Published: January 2018

AbstractDNA-based snapshots of ancient vegetation have shown that the composition of high-latitude plant communities changed considerably during the late Quaternary. However, parallel changes in biotic interactions remain largely uninvestigated. Here we show how mutualisms involving plants and heterotrophic organisms varied during the last 50,000 years. During 50–25 ka BP, a cool period featuring stadial-interstadial fluctuations, arbuscular mycorrhizal and non-N-fixing plants predominated. During 25-15 ka BP, a cold, dry interval, the representation of ectomycorrhizal, non-mycorrhizal and facultatively mycorrhizal plants increased, while that of N-fixing plants decreased further. From 15 ka BP, which marks the transition to and establishment of the Holocene interglaciation, representation of arbuscular mycorrhizal plants decreased further, while that of ectomycorrhizal, non-mycorrhizal, N-fixing and wind-pollinated plants increased. These changes in the mutualist trait structure of vegetation may reflect responses to historical environmental conditions that are without current analogue, or biogeographic processes, such as spatial decoupling of mutualist partners.
Maturation of the gut microbiome and risk of asthma in childhood
Authors: Stokholm Jakob , Blaser Martin J. , Thorsen Jonathan , Rasmussen Morten A. , Waage Johannes , Vinding Rebecca K. , Schoos Ann-Marie M. , Kunøe Asja , Fink Nadia R. , Chawes Bo L. , Bønnelykke Klaus , Brejnrod Asker D. , Mortensen Martin S. , Al-Soud Waleed Abu , Sørensen Søren J. , Bisgaard Hans 
Published: January 2018

AbstractThe composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.
Understanding the physical metallurgy of the CoCrFeMnNi high-entropy alloy: an atomistic simulation study
Authors: Choi Won-Mi , Jo Yong Hee , Sohn Seok Su , Lee Sunghak , Lee Byeong-Joo 
Published: January 2018

AbstractAlthough high-entropy alloys (HEAs) are attracting interest, the physical metallurgical mechanisms related to their properties have mostly not been clarified, and this limits wider industrial applications, in addition to the high alloy costs. We clarify the physical metallurgical reasons for the materials phenomena (sluggish diffusion and micro-twining at cryogenic temperatures) and investigate the effect of individual elements on solid solution hardening for the equiatomic CoCrFeMnNi HEA based on atomistic simulations (Monte Carlo, molecular dynamics and molecular statics). A significant number of stable vacant lattice sites with high migration energy barriers exists and is thought to cause the sluggish diffusion. We predict that the hexagonal close-packed (hcp) structure is more stable than the face-centered cubic (fcc) structure at 0 K, which we propose as the fundamental reason for the micro-twinning at cryogenic temperatures. The alloying effect on the critical resolved shear stress (CRSS) is well predicted by the atomistic simulation, used for a design of non-equiatomic fcc HEAs with improved strength, and is experimentally verified. This study demonstrates the applicability of the proposed atomistic approach combined with a thermodynamic calculation technique to a computational design of advanced HEAs.
High resolution NanoSIMS imaging of deuterium distributions in 316 stainless steel specimens after fatigue testing in high pressure deuterium environment
Authors: McMahon Greg , Miller Bryan D. , Burke M. Grace 
Published: January 2018

AbstractIt is irrefutable that the presence of hydrogen reduces the mechanical performance of many metals and alloys used for structural components. Several mechanisms of hydrogen-assisted cracking (HAC) of steels have been postulated. The direct evidence of the mechanisms by which hydrogen embrittles these materials has remained elusive. This is by virtue of our difficulty to directly observe the hydrogen distribution at spatial resolutions less than 100 nm and analysis volumes greater than 1 × 109atoms at microstructural features such as grain boundaries, dislocations, twins, stacking faults and sub-micron inclusions that are all potential hydrogen trapping sites postulated to be responsible for the degradation of mechanical performance. Here, we report on an experimental methodology combining an elaborate fatigue testing protocol in an enriched gaseous deuterium environment with NanoSIMS (secondary ion mass spectrometry) imaging for detection of deuterium at spatial resolutions as low as 100 nm and accompanying TEM analysis. Type 316 stainless steel compact tension specimens were precharged in deuterium followed by fatigue testing at high stress ratio (0.7), low delta K (~11 MPa √m), and a frequency of 1 cycle per minute using a sawtooth waveform with a rise time of 30 s in high pressure (68.9 MPa) gaseous deuterium (99.999% purity) environment at room temperature. High resolution NanoSIMS imaging was then used to measure the deuterium distribution at the tip of and in the wake of secondary and tertiary fatigue cracks as well as at MnS inclusions. The use of deuterium eliminates the difficulties of interpreting hydrogen measurements by SIMS relating to the ubiquitous presence of hydrogen in all high vacuum systems and guarantees that deuterium measured by the NanoSIMS must be attributed to the fatigue testing protocol. This methodology has allowed us to directly observe the distribution of hydrogen in dislocation tangles ahead and in the wake of fatigue crack tips and at the interface of MnS inclusions. The protocol provides an avenue by which the path and speed with which hydrogen proceeds along its embrittling course of action may be directly followed through modifications of the fatigue testing parameters and/or alloy type and allows a means to validate at least qualitatively recently published models of enhanced hydrogen transport by dislocations.
Mechanisms of interactive specialization and emergence of functional brain circuits supporting cognitive development in children
Authors: Battista Christian , Evans Tanya M. , Ngoon Tricia J. , Chen Tianwen , Chen Lang , Kochalka John , Menon Vinod 
Published: January 2018

AbstractCognitive development is thought to depend on the refinement and specialization of functional circuits over time, yet little is known about how this process unfolds over the course of childhood. Here we investigated growth trajectories of functional brain circuits and tested an interactive specialization model of neurocognitive development which posits that the refinement of task-related functional networks is driven by a shared history of co-activation between cortical regions. We tested this model in a longitudinal cohort of 30 children with behavioral and task-related functional brain imaging data at multiple time points spanning childhood and adolescence, focusing on the maturation of parietal circuits associated with numerical problem solving and learning. Hierarchical linear modeling revealed selective strengthening as well as weakening of functional brain circuits. Connectivity between parietal and prefrontal cortex decreased over time, while connectivity within posterior brain regions, including intra-hemispheric and inter-hemispheric parietal connectivity, as well as parietal connectivity with ventral temporal occipital cortex regions implicated in quantity manipulation and numerical symbol recognition, increased over time. Our study provides insights into the longitudinal maturation of functional circuits in the human brain and the mechanisms by which interactive specialization shapes children’s cognitive development and learning.
The Role Of Parafacial Neurons In The Control Of Breathing During Exercise
Authors: Korsak Alla , Sheikhbahaei Shahriar , Machhada Asif , Gourine Alexander V. , Huckstepp Robert T. R 
Published: January 2018

AbstractNeuronal cell groups residing within the retrotrapezoid nucleus (RTN) and C1 area of the rostral ventrolateral medulla oblongata contribute to the maintenance of resting respiratory activity and arterial blood pressure, and play an important role in the development of cardiorespiratory responses to metabolic challenges (such as hypercapnia and hypoxia). In rats, acute silencing of neurons within the parafacial region which includes the RTN and the rostral aspect of the C1 circuit (pFRTN/C1), transduced to express HM4D (Gi-coupled) receptors, was found to dramatically reduce exercise capacity (by 60%), determined by an intensity controlled treadmill running test. In a model of simulated exercise (electrical stimulation of the sciatic or femoral nerve in urethane anaesthetised spontaneously breathing rats) silencing of the pFRTN/C1 neurons had no effect on cardiovascular changes, but significantly reduced the respiratory response during steady state exercise. These results identify a neuronal cell group in the lower brainstem which is critically important for the development of the respiratory response to exercise and, determines exercise capacity.
Characterization of novel endo-β-N-acetylglucosaminidases from Sphingobacterium species, Beauveria bassiana and Cordyceps militaris that specifically hydrolyze fucose-containing oligosaccharides and human IgG
Authors: Huang Yibo , Higuchi Yujiro , Kinoshita Takashi , Mitani Ai , Eshima Yasunari , Takegawa Kaoru 
Published: January 2018

AbstractEndo-β-N-acetylglucosaminidase (ENGase) catalyzes hydrolysis of N-linked oligosaccharides. Although many ENGases have been characterized from various organisms, so far no fucose-containing oligosaccharides-specific ENGase has been identified in any organism. Here, we screened soil samples, using dansyl chloride (Dns)-labeled sialylglycan (Dns-SG) as a substrate, and discovered a strain that exhibits ENGase activity in the culture supernatant; this strain, named here as strain HMA12, was identified as a Sphingobacterium species by 16S ribosomal RNA gene analysis. By draft genome sequencing, five candidate ENGase encoding genes were identified in the genome of this strain. Among them, a recombinant protein purified from Escherichia coli expressing the candidate gene ORF1188 exhibited fucose-containing oligosaccharides-specific ENGase activity. The ENGase exhibited optimum activities at very acidic pHs (between pH 2.3–2.5). A BLAST search using the sequence of ORF1188 identified two fungal homologs, one in Beauveria bassiana and the other in Cordyceps militaris. Recombinant ORF1188, Beauveria and Cordyceps ENGases released the fucose-containing oligosaccharides residues from rituximab (immunoglobulin G) but not the high-mannose-containing oligosaccharides residues from RNase B, a result that not only confirmed the substrate specificity of these novel ENGases but also suggested that natural glycoproteins could be their substrates.
Multi-label Deep Learning for Gene Function Annotation in Cancer Pathways
Authors: Guan Renchu , Wang Xu , Yang Mary Qu , Zhang Yu , Zhou Fengfeng , Yang Chen , Liang Yanchun 
Published: January 2018

AbstractThe war on cancer is progressing globally but slowly as researchers around the world continue to seek and discover more innovative and effective ways of curing this catastrophic disease. Organizing biological information, representing it, and making it accessible, or biocuration, is an important aspect of biomedical research and discovery. However, because maintaining sophisticated biocuration is highly resource dependent, it continues to lag behind the continually being generated biomedical data. Another critical aspect of cancer research, pathway analysis, has proven to be an efficient method for gaining insight into the underlying biology associated with cancer. We propose a deep-learning-based model, Stacked Denoising Autoencoder Multi-Label Learning (SdaMLL), for facilitating gene multi-function discovery and pathway completion. SdaMLL can capture intermediate representations robust to partial corruption of the input pattern and generate low-dimensional codes superior to conditional dimension reduction tools. Experimental results indicate that SdaMLL outperforms existing classical multi-label algorithms. Moreover, we found some gene functions, such as Fused in Sarcoma (FUS, which may be part of transcriptional misregulation in cancer) and p27 (which we expect will become a member viral carcinogenesis), that can be used to complete the related pathways. We provide a visual tool (https://www.keaml.cn/gpvisual) to view the new gene functions in cancer pathways.
Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids
Authors: Wammers Marianne , Schupp Anna-Kathrin , Bode Johannes G. , Ehlting Christian , Wolf Stephanie , Deenen René , Köhrer Karl , Häussinger Dieter , Graf Dirk 
Published: January 2018

AbstractCholestasis is caused by autoimmune reactions, drug-induced hepatotoxicity, viral infections of the liver and the obstruction of bile ducts by tumours or gallstones. Cholestatic conditions are associated with impaired innate and adaptive immunity, including alterations of the cellular functions of monocytes, macrophages, NK cells and T-cells. Bile acids act as signalling molecules, affectinglipopolysaccharide(LPS)-induced cytokine expression in primary human macrophages. The present manuscript investigates the impact of bile acids, such astaurolithocholic acid(TLC), on the transcriptome of human macrophages in the presence or absence of LPS. While TLC itself has almost no effect on gene expression under control conditions, this compound modulates the expression of 202 out of 865 transcripts in the presence of LPS. Interestingly, pathway analysis revealed that TLC specifically supressed the expression of genes involved in mediating pro-inflammatory effects, phagocytosis, interactions with pathogens and autophagy as well as the recruitment of immune cells, such as NK cells, neutrophils and T cells. These data indicate a broad influence of bile acids on inflammatory responses and immune functions in macrophages. These findings may contribute to the clinical observation that patients with cholestasis present a lack of response to bacterial or viral infections.