bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: REACTIONS WITH AZO COMPOUNDS. 6. (3 + 2)‐CYCLOADDITIONS OF AZOALKENES TO ENAMINES ‐ “CRISS‐CROSS” CYCLOADDITIONS TO AZOALKENES
Authors: SOMMER S. 
Published: April 2016

AbstractDie Azoalkene (I) reagieren mit den Enaminen (II) zu den [3 + 2]‐Cycloaddukten (III), die beim Erhitzen über den Schmelzpunkt in die Aminopyrrolderivate (IV) ((IVa) entsteht sowohl aus (IIIa) als auch aus (IIIb)) übergehen.
ChemInform Abstract: 1,3‐DIPOLAR CYCLOADDITIONS TO STRAINED OLEFINS
Authors: BECKER K. B. , HOHERMUTH M. K. 
Published: April 2016

AbstractDie Bredt‐Olefine (IV), (VII) bzw. (X) reagieren mit den Dipolen (I), (II) bzw. (III) unter Bildung von Isomerengemischen (V) + (VI) bzw. (VIII)+(IX) bzw. (XI) + (XII); die Cycloaddition an das monocyclische E‐Cycloolefin (XIII) ist dagegen regioselektiv [→ (XVa), (XIVb) bzw. (XIVc)].
ChemInform Abstract: STUDIES ON ORGANIC FLUORINE COMPOUNDS. PART 26. DIELS‐ALDER REACTION OF HEXAKIS(TRIFLUOROMETHYL)BICYCLO(2.2.0)HEXA‐2,5‐DIENE
Authors: KOBAYASHI Y. , NAKANO T. , TAKAHASHI R. , KUMADAKI I. 
Published: April 2016

AbstractDie bisher gegenüber Dienen inert geglaubte Titelverbindung (III) reagiert bei 140°C mit den Dienen (II) oder (IV) unter Bildung der Diels‐Alder‐Addukte (I) bzw. (V).
ChemInform Abstract: REARRANGEMENTS OF HETEROCYCLES. VIII. MESOIONIC SIX‐MEMBERED‐RING HETEROCYCLES. XII. KETENOID REARRANGEMENTS OF MESOIONIC PYRIMIDINES
Authors: KAPPE T. , LUBE W. 
Published: April 2016

AbstractDie Pyridopyrimidin‐Mesoionen (I) lagern sich bei 260‐300°C über die resonanzstabilisierten Ketene (II)/(III) in die Chinolone (IV) um.
ChemInform Abstract: FIRST CONVERSION OF A CIS‐RHEADAN TO A TRANS‐RHEADAN
Authors: HOHLBRUGGER R. , KLOETZER W. 
Published: April 2016

AbstractDie bei der alkalischen Hydrolyse des rac. cis‐Oxyrheagenins (I) entstehende cis‐Säure (II) wird in Gegenwart von Triphenylphosphan/Azodicarbonsäurediethylester unter Invertierung am alkoholischen C‐Atom zu dem trans‐Isomeren (III) und (I) lactonisiert.
ChemInform Abstract: ORGANIC REACTIONS IN A SOLID MATRIX. V. SILICA‐GEL SUPPORTED CHROMIC ACID REAGENTS
Authors: SINGH R. P. , SUBBARAO H. N. , DEV S. 
Published: April 2016

AbstractPyridiniumchromat oder Na2Cr2O7 · 2 H2O/H2SO4 auf Silicagel‐Trägern erweisen sich als "off‐the‐shelf"‐Reagenzien für eine effiziente Oxidation prim. bzw. sek. Alkohole zu Aldehyden bzw. Ketonen.
ChemInform Abstract: ACYLATION OF PRIMARY AMINES BY O‐ACYL OXIMES
Authors: KUMAR P. , MUKERJEE A. K. 
Published: April 2016

AbstractN‐Benzoylaminosäuren (I) werdcn mit Chlorameisensäureester in Oxazolin‐Derivate (II) übergeführt, die mit Cyclo‐ hexanonoxim (III) unter Ringöffnung aktivierte Oximester (IV) bilden.
ChemInform Abstract: CATALYTIC ASYMMETRIC HYDROFORMYLATION BY THE USE OF RHODIUM COMPLEXES OF CHIRAL BIDENTATE PHOSPHORUS LIGANDS BEARING SATURATED RING SKELETONS
Authors: HAYASHI T. , TANAKA M. , IKEDA Y. , OGATA I. 
Published: April 2016

AbstractDie Verbindungen (I)‐(IV) werden als chirale zweizähnige Liganden bei Rh‐katalysierten asymm. Hydroformylierungen der Olefine (V) eingesetzt.
ChemInform Abstract: SYNTHESIS OF α‐AMINO ACIDS BY ALKYLATION OF DIETHYL ACETAMIDOMALONATE IN THE PRESENCE OF PALLADIUM COMPLEXES
Authors: HAUDEGOND J. P. , CHAUVIN Y. , COMMEREUC D. 
Published: April 2016

AbstractAus Acetamidomalonsäurediethylester (Ia) bzw. seinem Na‐Salz (Ib) erhält man in Gegenwart von Pd‐Katalysatoren mit Butadien und Isopren (IIa) und (IIb) die Kondensationsprodukte (III), die zu (IV) hydriert und zu Aminosäuren wie (Va) verseift werden.
ChemInform Abstract: SYNTHESIS OF SEVERAL BENZYLOXYPHENYL DERIVATIVES WITH LOCAL ANESTHETIC ACTIVITY
Authors: VON RUDIGER‐ADLER E. , BUECHI J. 
Published: April 2016

AbstractDie aus p‐Hydroxyacetophenon (I) und den Benzylchloriden (II) erhaltenen p‐Benzyloxyacetophenone (III) lassen sich nach Mannich mit Paraformaldehyd (IV) und den sekundären Aminen (V) zu den p‐Benzyloxy‐β‐aminopropiophenonen (VI) umsetzen.
ChemInform Abstract: THE CARBANIONS OF S‐ALKANOATE‐O,O‐DIALKYL PHOSPHATES: NEW SYNTHONS FOR REACHING α,β‐ETHYLENIC ESTERS
Authors: BABOULENE M. , STURTZ G. 
Published: April 2016

AbstractDie Thiolphosphate (I) bilden mit Lithium‐diisopropylamid (LDA) Carbanionen (II), die mit den Ketonen (III) zu ungesättigten Estern (IV) umgesetzt werden.
ChemInform Abstract: SYNTHESIS, ANTIBACTERIAL AND ANALGESIC ACTIVITIES OF BENZHYDRYL DERIVATIVES OF HYDROXY‐ AND AMINO‐BENZOIC ACIDS
Authors: TAKEMURA S. , TERAUCHI H. , MIKI Y. , NAKANO L. , INAMORI Y. , MIYAZEKI K. , NISHIMURA H. 
Published: April 2016

AbstractDie antibakterielle Wirkung einer Reihe von Benzhydrylderivatcn der p‐ und m‐Hydroxy‐ sowie der p‐ und m‐Aminobenzoesäure wird untersucht.
ChemInform Abstract: SYNTHESIS OF O‐(ARYLVINYL)‐ AND O‐(HETEROARYLVINYL)PHENOLS
Authors: FRANKE A. , FRICKEL F.‐F. , SCHLECKER R. , THIEME P. C. 
Published: April 2016

AbstractSalicylaldehyd (I) wird durch Addition an Methyl‐vinylether (II) als Acetal (III) geschützt und ergibt nach nach Olefinierung Stilben‐Derivate (V), die sauer zu Phenolen (VI) verseift werden.
ChemInform Abstract: STEREOSELECTIVE NUCLEOPHILIC ATTACKS ON CARBENIUM IONS GENERATED FROM (1‐INDANOL)‐ AND (1‐TETRALOL)CHROMIUM TRICARBONYL AS SYNTHETIC INTERMEDIATES
Authors: TOP S. , MEYER A. , JAOUEN G. 
Published: April 2016

AbstractAus dem Chromcarbonylkomplex (III) erhält man mit Schwefelsäure und Wasser bzw. Methanol die Umlagerungsprodukte (II) bzw. (IV), die in Gegenwart von Sauerstoff photolytisch zu den Chromfreien Verbindungen (I) bzw. (V) gespalten werden.
ChemInform Abstract: DIBENZOTETRACYCLIC DERIVATIVES. II. SYNTHESIS OF 9‐AMINOALKYL‐9,10‐DIHYDRO‐9,10‐METHANOANTHRACENES
Authors: SUNAGAWA M. , SATO H. , KATSUBE J. , YAMAMOTO H. 
Published: April 2016

AbstractDer Anthracenaldehyd (I) wird über die Verbindungen (III) bis (VI) in die Schlüsselverbindung (VII) umgewandelt, die in die Carbonsäuren (VIII), (IX), (XII) sowie in die Amine (XIV) übergeführt wird.
ChemInform Abstract: NEW SYNTHESIS OF β‐LACTAMS
Authors: MORI M. , CHIBA K. , OKITA M. , BAN Y. 
Published: April 2016

AbstractDas Dibromid (I) liefert das Bromamin (II), das mit Kohlenmonoxid in Gegenwart von Triphenylphosphin und Palladiumacetat zum β‐Lactam (III) reagiert.
ChemInform Abstract: SYNTHESIS OF PYRAZOLONE DERIVATIVES. XXXVIII. (1,5)SIGMATROPIC REARRANGEMENT DURING THE CYCLOADDITION OF (1R,4S)‐3‐DIAZOBORNAN‐2‐ONE TO ACTIVATED ACETYLENES
Authors: NAGAI S. , ODA N. , ITO I. 
Published: April 2016

AbstractDas Diazobornanon (I) reagiert mit den Acetylencarbonsäureestern (II) über eine Spiropyrazol‐Zwischenstufe (III) im Wege einer [1,5]‐sigmatropen Acylumlagerung zu den Verbindungen (IV) und (V).
ChemInform Abstract: THE SYNTHESIS OF α‐TOCOPHEROL VIA 2‐(SULFINYLMETHYL)CHROMANS
Authors: AKKERMAN J. M. , DE KONING H. , HUISMAN H. O. 
Published: April 2016

AbstractDas Phenylmercaptomethyl‐chromanol (IIIa) wird durch Kondensation des Hydrochinons (I) mit dem Hydroxysulfid (II) in Gegenwart von B‐trifluoridetherat synthetisiert.
ChemInform Abstract: A FACILE PROTECTING GROUP FOR THE SYNTHESIS OF 2‐OXO‐2H,8H‐BENZO(1,2‐B:5,4‐B′)DIPYRANS
Authors: AHLUWALIA V. K. , PRAKASH C. , SINGH R. P. 
Published: April 2016

Abstract7‐Hydroxy‐benzopyranon (I) wird mit 3‐Chlor‐3‐methylbutin (II) zu (III) verethert und beim Erhitzen in siedendem N,N‐Dimethylanilin unter Abspaltung von Iodiod zum Benzo‐dipyran (IV) cyclisiert.
ChemInform Abstract: 1‐PHENYLPYRIDAZINO(4,5‐D)PYRIDAZINE
Authors: CHIMICHI S. , NESI R. 
Published: April 2016

AbstractDie Behandlung des Pyridazindicarbonsäureanhydrids (I) mit Benzol und AlCl3 führte zu der Säure (IIa), die durch Methylierung mit Diazomethan in ihren Ester (IIb) umgewandelt wurde.
ChemInform Abstract: STUDIES ON PSYCHOTROPIC AGENTS. IV. ALKYLATION OF 2‐SUBSTITUTED 2,3,4,5‐TETRAHYDRO‐1H‐PYRIDO(4,3‐B)INDOLE DERIVATIVES
Authors: NAGAI Y. , IRIE A. , UNO H. , MINAMI S. 
Published: April 2016

AbstractBei der Alkylierung der Tetrahydropyrido‐indole (I) in unpolaren Lösungsmitteln und in Gegenwart von Natriumamid erhält man die Verbindungen (III) und unter gleichzeitiger Umlagerung die Verbindungen (II).
ChemInform Abstract: REACTIONS OF THIOBIS(FORMAMIDINE). PART 5. SYNTHESIS OF (METHYLMERCAPTO)(ISOTHIOUREIDO)‐1,3,5‐TRIAZINES
Authors: EVERS R. , FISCHER E. 
Published: April 2016

AbstractDie Thiobioformamidine (I) cyclisieren mit dem Dithiokohlensäurediester (II) zu den Triazinen (III).
ChemInform Abstract: MECHANISM AND STEREOCHEMISTRY OF ADDITION REACTIONS OF SILYL‐ AND GERMYLPHOSPHINES TO UNSATURATED REAGENTS
Authors: ESCUDIE J. , COURET C. , DUBAC J. , CAVEZZAN J. , SATGE J. , MAZEROLLES P. 
Published: April 2016

AbstractStereoisomere der Art (I) reagieren mit Oxo‐Verbindungen (II), Ketenen (IV), Schwefelkohlenstoff, Phenylsenföl oder Acrylsäurederivaten (VIII) zu den Einschiebungsprodukten (III), (V)‐(VII) bzw. (IX) in guten Ausbeuten.
ChemInform Abstract: SYNTHESIS OF NEW GEM‐DIALKYLTETRACHLOROCYCLOPHOSPHAZENES VIA ′METALLOPHOSPHAZANE′ INTERMEDIATES
Authors: HARRIS P. J. , ALLCOCK H. R. 
Published: April 2016

AbstractHexachlorcyclotriphosphazen (II) wird über die Zwischenstufen (III) in die Derivate (IV) umgewandelt.
ChemInform Abstract: 1,1‐BIS(PHENYLSELENO)‐ AND 1,1‐BIS(METHYLSELENO)ALKYLLITHIUMS AS BUILDING BLOCKS IN ORGANIC SYNTHESIS
Authors: VAN ENDE D. , CRAVADOR A. , KRIEF A. 
Published: April 2016

AbstractDie Bis‐(phenylseleno)‐alkane (I) lassen sich durch Behandlung mit Lithium‐tetramethylpiperidid oder Lithium‐diisobutylamid in guten Ausbeuten metallieren.
ChemInform Abstract: THE PREPARATION OF SUBSTITUTED ALLYLLITHIUM REAGENTS FROM ALLYLTIN COMPOUNDS BY TRANSMETALATION
Authors: SEYFERTH D. , MAMMARELLA R. E. 
Published: April 2016

AbstractDie Allylzinnverbindungen (I)‐(IV) reagieren mit Methyllithium in Tetrahydrofuran zu substituierten Allyllithium‐Verbindungen.
ChemInform Abstract: TRANSITION METAL KETENE COMPOUNDS. VI. TRANSITION METAL‐SUBSTITUTED KETENES OF MOLYBDENUM AND TUNGSTEN ‐ PREPARATION, REACTIVITY, AND SPECTROSCOPIC STUDIES
Authors: UEDELHOVEN W. , EBERL K. , KREISSL F. R. 
Published: April 2016

AbstractDarstellung, Reaktivität und spektroskopische Untersuchung.
ChemInform Abstract: AMINO ACID COMPLEXES OF COBALT(III). PREPARATION AND HYDROLYSIS OF REACTIONS OF TRANS‐BIS(1,2‐DIAMINOETHANE)(AMINOCARBOXYLATO)HALOGENOCOBALT(III) COMPLEXES CONTAINING THE CARBOXYLATO‐BONDED AMINO ACIDS GLYCINE, DL‐ALANINE, AND DL‐AMINOBUTYRIC ACID
Authors: NOLAN K. B. , SOUDI A. A. 
Published: April 2016

AbstractDie trans‐Komplexe (I) wurden als Perchlorate durch Reaktion von Dihalogeno‐bis‐[ethylendiamin]‐cobalt(III)‐halogenid mit den Aminosäuren dargestellt und durch IR‐ und Elektronenspektren charakterisiert.
ChemInform Abstract: MONOMERIC BIS(DIALKYLPHOSPHONIUM BIS(METHYLIDE)) COMPLEXES OF NICKEL, PALLADIUM, AND PLATINUM
Authors: SCHMIDBAUR H. , BLASCHKE G. , SCHERM H. P. 
Published: April 2016

AbstractDie Bis‐[trimethylphosphin]‐Ni‐ und ‐Pd‐Komplexe (IIIa) und (IIIb) reagieren mit dem sterisch anspruchsvollen Ylid (II) im Molverhältnis 1:4 unter Umylidierung zum zugehörigen Phosphoniumsalz und den neuen Ylid‐Chelaten (Ia) und (Ib).
ChemInform Abstract: AMINO‐STEROIDS. PART 6. STEREOSPECIFIC SYNTHESES OF EIGHT, ISOMERIC, STEROIDAL VICINAL 2,3‐AMINO‐ALCOHOLS
Authors: CAMPBELL M. M. , CRAIG R. C. , BOYD A. C. , GILBERT I. M. , LOGAN R. T. , REDPATH J. , ROY R. G. , SAVAGE D. S. , SLEIGH T. 
Published: April 2016

AbstractAusgehend von Δ2‐5α‐Androstenon‐(17) werden 2α,3α‐ und 2β,3β‐Epoxide, Aziridine und Oxazoline dargestellt, die unter unterschiedlichen jeweils untereinander zusammenhängenden Reaktionsfolgen stereospezifisch in die isomeren Aminoalkohole (I) übergeführt werden.
Shannon entropy and Kullback–Leibler divergence in multivariate log fundamental skew‐normal and related distributions
Authors: De Queiroz Marina M. , Silva Roger W. C. , Loschi Rosangela H. 
Published: April 2016

AbstractThis article mainly focuses on studying the Shannon entropy and Kullback–Leibler divergence of the multivariate log‐canonical fundamental skew‐normal (LCFUSN) and canonical fundamental skew‐normal (CFUSN) families of distributions, extending previous works. We relate our results with entropies of other well‐known distributions. As a by‐product we also obtain the mutual information for distributions in these families. Shannon entropy is used to compare models fitted to analyze monthly USA precipitation data. Kullback–Leibler divergence is used to cluster regions in the Atlantic ocean according to their air humidity level.The Canadian Journal of Statistics44: 219–237; 2016 © 2016 Statistical Society of Canada
Long‐term Cost‐Effectiveness of Diagnostic Tests for Assessing Stable Chest Pain: Modeled Analysis of Anatomical and Functional Strategies
Authors: Bertoldi Eduardo G. , Stella Steffan F. , Rohde Luis E. , Polanczyk Carisi A. 
Published: April 2016

ABSTRACTSeveral tests exist for diagnosing coronary artery disease, with varying accuracy and cost. We sought to provide cost‐effectiveness information to aid physicians and decision‐makers in selecting the most appropriate testing strategy. We used the state‐transitions (Markov) model from the Brazilian public health system perspective with a lifetime horizon. Diagnostic strategies were based on exercise electrocardiography (Ex‐ECG), stress echocardiography (ECHO), single‐photon emission computed tomography (SPECT), computed tomography coronary angiography (CTA), or stress cardiac magnetic resonance imaging (C‐MRI) as the initial test. Systematic review provided input data for test accuracy and long‐term prognosis. Cost data were derived from the Brazilian public health system. Diagnostic test strategy had a small but measurable impact in quality‐adjusted life‐years gained. Switching from Ex‐ECGtoCTA‐based strategies improved outcomes at an incremental cost‐effectiveness ratio of 3100 international dollars per quality‐adjusted life‐year.ECHO‐based strategies resulted in cost and effectiveness almost identical toCTA, andSPECT‐based strategies were dominated because of their much higher cost. Strategies based on stress C‐MRIwere most effective, but the incremental cost‐effectiveness ratio vsCTAwas higher than the proposed willingness‐to‐pay threshold. Invasive strategies were dominant in the high pretest probability setting. Sensitivity analysis showed that results were sensitive to costs ofCTA,ECHO, and C‐MRI. CoronaryCTis cost‐effective for the diagnosis of coronary artery disease and should be included in the Brazilian public health system. StressECHOhas a similar performance and is an acceptable alternative for most patients, but invasive strategies should be reserved for patients at high risk.
Bob1 limits cellular frequency of T‐follicular helper cells
Authors: Yamashita Keiji , Kawata Koji , Matsumiya Hiroshi , Kamekura Ryuta , Jitsukawa Sumito , Nagaya Tomonori , Ogasawara Noriko , Takano Ken‐ichi , Kubo Terufumi , Kimura Sachiko , Shigehara Katsunori , Himi Tetsuo , Ichimiya Shingo 
Published: April 2016

T follicular helper (Tfh) cells are involved in specific humoral immunity at initial and recall phases. The fact that the transcription repressors B‐cell lymphoma‐6 and Blimp‐1 determine lineages of Tfh cells and other types of effector CD4+ T cells, respectively, suggests that there are unique mechanisms to establish Tfh‐cell identity. In this study, we found that Tfh cells preferentially express the transcriptional coactivator Bob1. Bob1 of Tfh cells was dispensable for the expression of B‐cell lymphoma‐6 and the functional property of the cells for B cell help. However, upon initial immunization of foreign antigens, the percentages of Tfh cells in Bob1−/− mice were much higher than those in wild‐type (WT) mice. In addition, expansion of Tfh cells within Bob1−/−CD4+ T cells transferred into WT mice revealed that the high frequency of Tfh cells was caused by a T‐cell‐intrinsic mechanism. These findings were further supported by the results of in vitro studies demonstrating that Bob1−/− Tfh cells had greater proliferative activity in response to stimuli by CD3/CD28 monoclonal antibody and were also refractory to CD3‐induced cell death in comparison to WT Tfh cells. These results suggest that Tfh cells harbor a Bob1‐related mechanism to restrict numerical frequency against stimulation of TCRs.
Synthesis of 4‐Vinyl‐1H‐1,2,3‐triazoles on Solid Supports via Polystyrene‐Bound But‐3‐ynyl Selenide
Authors: Ming Peng , Liu Xiao‐Ling , Wei Mei‐Hong , Sheng Shou‐Ri 
Published: April 2016

ABSTRACTA facile method for solid‐phase organic synthesis of 1‐substituted‐4‐vinyl‐1,2,3‐triazoles from polystyrene‐supported but‐3‐ynyl selenide has been developed. This sequential [3+2] cycloaddition and oxidation–elimination reactions could be carried out under mild reaction conditions with straightforward operation and good yield and purity of the products, and broad scope of substrates, and could be applied in this reaction system in generation of a small library of title compounds.
Decreased mitochondrial copy numbers in oral squamous cell carcinoma
Authors: Takeda Daisuke , Hasegawa Takumi , Ueha Takeshi , Sakakibara Akiko , Kawamoto Teruya , Minamikawa Tsutomu , Sakai Yoshitada , Komori Takahide 
Published: April 2016

AbstractBackgroundMitochondrial dysfunction and altered respiration have long been suspected to affect the development and progression of cancer. Although quantitative changes in mitochondrial DNA (mtDNA) have been reported in head and neck squamous cell carcinoma (SCC), differences in mtDNA copy numbers between normal and cancerous tissues from same patients have not been assessed.MethodsWe compared mtDNA copy numbers and expressions of peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α) and mitochondrial transcription factor A (TFAM) between normal mucous membrane and cancerous tissues resected from 35 patients with oral SCC, using TaqMan quantitative real‐time polymerase chain reaction (PCR) and immunohistochemical staining.ResultsWe found mtDNA copy numbers and expressions of PGC‐1α and TFAM were decreased in cancerous tissues compared with normal tissues from the same patients.ConclusionThe PGC‐1α–TFAM mitochondrial pathway may be associated with malignant potential in human oral SCC, and could be an attractive therapeutic target. © 2016 Wiley Periodicals, Inc. Head Neck 38:1170–1175, 2016
Clinical characteristics and outcomes of oropharyngeal carcinoma related to high‐risk non–human papillomavirus16 viral subtypes
Authors: Varier Indu , Keeley Brieze R. , Krupar Rosemarie , Patsias Alexis , Dong Joanna , Gupta Nikita , Parasher Arjun K. , Genden Eric M. , Miles Brett A. , Teng Marita , Bakst Richard L. , Gupta Vishal , Misiukiewicz Krzysztof J. , Chiao Elizabeth Y. , Scheurer Michael E. , Laban Simon , Zhang David , Ye Fei , Cui Miao , Demicco Elizabeth G. , Posner Marshall R. , Sikora Andrew G. 
Published: April 2016

AbstractBackgroundThe majority of human papillomavirus (HPV)‐related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high‐risk non‐HPV16 genotypes.MethodsThis was a retrospective analysis of patients with high‐risk non‐HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high‐risk non‐HPV16 groups.ResultsHigh‐risk non‐HPV16 genotypes accounted for 9% of HPV‐related OPC. Of the 27 total high‐risk non‐HPV16 OPCs, HPV35 was most prevalent (48%). High‐risk non‐HPV16 OPC presented at a slightly higher age (p = .021) and higher clinical T classification (p = .008) compared to HPV16 OPC, but there was no significant survival difference.ConclusionClinical characteristics of high‐risk non‐HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi‐institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high‐risk HPV types. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1330–1337, 2016
Salivary duct carcinoma of the sinonasal cavity: A case report and review of the literature
Authors: Müller Sarina , Mantsopoulos Konstantinos , Iro Heinrich , Agaimy Abbas 
Published: April 2016

ABSTRACTBackgroundSalivary duct carcinoma is a rare, aggressive tumor entity first described by Kleinsasser et al in 1968, as a group of malignant salivary gland tumors characterized by duct formation and central necrosis. A case with an unusual localization in the nasal cavity and maxillary sinus is being described in our report.MethodsA 60‐year‐old patient presented with difficulty of nasal breathing and recurrent episodes of epistaxis from the left nasal cavity over the previous 3 months. On endoscopy, a vulnerable lesion in the left inferior nasal meatus could be seen. Biopsy showed salivary duct carcinoma. Treatment consisted of tumor resection by means of a combined endoscopic‐osteoplastic surgical approach to the maxillary sinus, bilateral neck dissection, partial parotidectomy, and adjuvant radiochemotherapy.ResultsThe patient is 6 months after completion of treatment and is free of disease.ConclusionAs salivary duct carcinoma of the sinonasal tract is extremely rare, no therapeutic standards have been developed and treatment essentially is based upon experience with ductal adenocarcinoma of the salivary glands. Surgery therapy should be radical, aiming at eradicating locoregional disease with the role of adjuvant radiotherapy lying in the management of cases with negative prognostic factors. © 2016 Wiley Periodicals, Inc. Head Neck 38:E2464–E2466, 2016
Transthyrohyoid access to the larynx for endoscopic resection of early‐stage glottic cancer
Authors: Monnier Yan , Schoettker Patrick , Morisod Benoit , Ikonomidis Christos , Simon Christian 
Published: April 2016

AbstractBackgroundThe effectiveness of transoral microsurgery for early‐stage glottic cancer relies on the possibility to obtain adequate exposure of the lesion. The purpose of this study was to design a new surgical technique allowing efficient endoscopic removal of these tumors in patients with unsatisfactory transoral exposure.MethodsA minimal invasive access to the glottis, made through the thyrohyoid membrane and the preepiglottic space, was used for endoscopic resection of an early‐stage glottic tumor in a patient with a medical history of previous radiotherapy and unsatisfactory endoscopic exposure of the lesion.ResultsThis approach provided excellent exposure of the glottis and allowed endoscopic resection with adequate surgical margins. The surgical procedure and the postoperative period were uneventful. Functional outcomes were back to baseline after 1 month.ConclusionThis technique represents an attractive solution for patients presenting with early‐stage glottic tumors that cannot be exposed transorally and have contraindications to alternative therapeutic procedures. © 2016 Wiley Periodicals, Inc. Head Neck 38:1286–1289, 2016