bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive impairment, self‐perceived health and quality of life of older prisoners
Authors: Combalbert Nicolas , Pennequin Valérie , Ferrand Claude , Armand Marine , Anselme Morgane , Geffray Brigitte 
Published: March 2017

AbstractBackgroundThere is a wealth of studies of somatic and mental illness among prisoners, but little on older prisoners and their cognitive aging.AimsOur study examines the cognitive performance of older male prisoners and its effect on their perceived health and quality of life.MethodsA total of 138 men aged 50 or over were recruited in seven French prisons and 138 men of similar ages from the general population. Two assessments of executive cognitive functions – the mini‐mental state examination and the frontal assessment battery – were administered to each participant, together with self rating schedules of health (Nottingham Health Profile), subjective state of mental health and quality of life (the brief World Health Organisation Quality of Life Questionnaire).ResultsThere were very significant differences between the two groups in terms of cognitive performance, perceived health and quality of life. There was, however, no significant association between cognitive impairment and perceived health or quality of life.ConclusionsWe found evidence that about a fifth of male prisoners in France had executive function test scores suggestive of at least moderately severe dementia and many others some evidence of cognitive impairments. Prisoners suffering from cognitive impairment do not necessarily seek help, perhaps not even considering that their health or quality of life to be affected. Communication deficits may also prevent their participation in prison activities which could prevent, slow or halt cognitive decline. Consequently, it is important that systematic screening for cognitive disorders is offered to men over 50 in prison. Copyright © 2017 John Wiley & Sons, Ltd.
Design, Synthesis, and in vitro and in vivo Evaluations of (Z)‐3,4,5‐Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors
Authors: Mahesh Rasala , Nayak Vadithe Lakshma , Babu Korrapati Suresh , Riyaz Syed , Shaik Thokhir Basha , Kumar Gajjela Bharth , Mallipeddi Prema Latha , Reddy Challa Ratna , Shekar Kunta Chandra , Jose Jedy , Nagesh Narayana , Kamal Ahmed 
Published: March 2017

AbstractNewer therapeutics can be developed in drug discovery by adopting the strategy of scaffold hopping of the privileged scaffolds from known bioactive compounds. This strategy has been widely employed in drug‐discovery processes. Structure‐based docking studies illustrate the basic underlying concepts and reveal that interactions of the sulfonamide group and hydrophobic interactions are crucial. On the basis of this strategy, over 60 synthetic analogues were synthesized and evaluated for their cytotoxicity against the NCI panel of 60 human cancer cell lines; the majority of these compounds exhibited promising cytotoxicity with GI50 values ranging between 18 and 50 nm. Among these compounds, (Z)‐N‐[2,3‐dimethoxy‐5‐(3,4,5‐trimethoxystyryl)phenyl]‐4‐methoxybenzenesulfonamide (7 a) and (Z)‐N‐[2‐hydroxy‐3‐methoxy‐6‐(3,4,5‐trimethoxystyryl)phenyl]‐4‐methoxybenzenesulfonamide (9 a) were found to be potent. Similar results were obtained against three human cancer cell lines with IC50 values ranging between 0.04 and 3.0 μm. Studies aimed at elucidating the mechanism of action of these new analogues revealed that they inhibited the in vitro polymerization of tubulin and disorganized the assembly of microtubules in HeLa and MCF‐7cancer cells. Lead compounds 7 a and 9 a displayed notable in vivo antitumor activity in a HeLa tumor xenograft model. Our studies have resulted in the identification of a scaffold that can target tubulin polymerization, which should have significant potential toward the development of new antitumor drugs.
Dissecting Solidago canadensis–soil feedback in its real invasion
Authors: Dong Li‐Jia , Yang Jian‐Xia , Yu Hong‐Wei , He Wei‐Ming 
Published: March 2017

AbstractThe importance of plant–soil feedback (PSF) has long been recognized, but the current knowledge on PSF patterns and the related mechanisms mainly stems from laboratory experiments. We aimed at addressing PSF effects on community performance and their determinants using an invasive forb Solidago canadensis. To do so, we surveyed 81 pairs of invaded versus uninvaded plots, collected soil samples from these pairwise plots, and performed an experiment with microcosm plant communities. The magnitudes of conditioning soil abiotic properties and soil biotic properties by S. canadensis were similar, but the direction was opposite; altered abiotic and biotic properties influenced the production of subsequent S. canadensis communities and its abundance similarly. These processes shaped neutral S. canadensis–soil feedback effects at the community level. Additionally, the relative dominance of S. canadensis increased with its ability of competitive suppression in the absence and presence of S. canadensis–soil feedbacks, and S. canadensis‐induced decreases in native plant species did not alter soil properties directly. These findings provide a basis for understanding PSF effects and the related mechanisms in the field conditions and also highlight the importance of considering PSFs holistically.
Effects of genetically modified maize events expressing Cry34Ab1, Cry35Ab1, Cry1F, and CP4 EPSPS proteins on arthropod complex food webs
Authors: Pálinkás Zoltán , Kiss József , Zalai Mihály , Szénási Ágnes , Dorner Zita , North Samuel , Woodward Guy , Balog Adalbert 
Published: March 2017

AbstractFour genetically modified (GM) maize (Zea mays L.) hybrids (coleopteran resistant, coleopteran and lepidopteran resistant, lepidopteran resistant and herbicide tolerant, coleopteran and herbicide tolerant) and its non‐GM control maize stands were tested to compare the functional diversity of arthropods and to determine whether genetic modifications alter the structure of arthropods food webs. A total number of 399,239 arthropod individuals were used for analyses. The trophic groups’ number and the links between them indicated that neither the higher magnitude of Bt toxins (included resistance against insect, and against both insects and glyphosate) nor the extra glyphosate treatment changed the structure of food webs. However, differences in the average trophic links/trophic groups were detected between GM and non‐GM food webs for herbivore groups and plants. Also, differences in characteristic path lengths between GM and non‐GM food webs for herbivores were observed. Food webs parameterized based on 2‐year in‐field assessments, and their properties can be considered a useful and simple tool to evaluate the effects of Bt toxins on non‐target organisms.
Community assembly inNothobranchiusannual fishes: Nested patterns, environmental niche and biogeographic history
Authors: Reichard Martin , Janáč Michal , Polačik Matej , Blažek Radim , Vrtílek Milan 
Published: March 2017

AbstractThe assembly of local communities from regional species pools is shaped by historical aspects of distribution, environmental conditions, and biotic interactions. We studied local community assembly patterns in African annual killifishes of the genusNothobranchius(Cyprinodontiformes), investigating data from 168 communities across the entire range of regionally co‐existing species.Nothobranchiusare small fishes associated with annually desiccating pools. We detected a nested pattern of local communities in one region (Southern Mozambique, withNothobranchius furzerias the core and dominant species), but no nestedness was found in the second region (Central Mozambique, withNothobranchius orthonotusbeing the dominant species). A checkerboard pattern of localNothobranchiuscommunity assembly was demonstrated in both regions. Multivariate environmental niche modeling revealed moderate differences in environmental niche occupancy between three monophyletic clades that largely co‐occurred geographically and greater differences between strictly allopatric species within the clades. Most variation among species was observed along an altitudinal gradient;N. furzeriandNothobranchius kadleciwere absent from coastal plains,Nothobranchius pienaari,Nothobranchius rachovii, andNothobranchius krysanoviwere associated with lower altitude andN. orthonotuswas intermediate and geographically most widespread species. We discuss implications for ecological and evolutionary research in this taxon.
Evaluating models of population process in a threatened population of Steller's eiders: a retrospective approach
Authors: Dunham Kylee , Grand James B. 
Published: March 2017

AbstractThe Alaskan breeding population of Steller's eiders (Polysticta stelleri) was listed as threatened under the Endangered Species Act in 1997 in response to declines in abundance and a contraction in their breeding and nesting range. Aerial surveys suggest the breeding population is small and breeds in highly variable numbers, with zero birds counted in five of the last 25 years. The primary objective of this research was to evaluate competing population process models of Alaskan breeding Steller's eiders through comparison of model projections to aerial survey data. To evaluate model efficacy and estimate demographic parameters, we used a Bayesian state‐space modeling framework and fit each model to counts from the annual aerial surveys using sequential importance sampling/resampling. The results strongly support that the Alaskan breeding population experiences population‐level non‐breeding events, and is open to exchange with the larger Russian‐Pacific breeding population. Current recovery criteria for the Alaskan breeding population rely heavily on the ability to estimate population viability. Our results provide an informative model of population process that can be used to examine future population states and assess the population in terms of the current recovery and reclassification criteria.
Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma
Authors: Lin Chin Shien , de Oliveira Santos André Bandiera , Silva Evandro Lima e , de Matos Leandro Luongo , Moyses Raquel Ajub , Kulcsar Marco Aurélio Vamondes , Pinto Fábio Roberto , Brandão Lenine Garcia , Cernea Claudio Roberto 
Published: March 2017

ABSTRACTBackgroundThe purpose of the present study was to investigate the role of tumor volume in the prognosis of patients with oral cavity squamous cell carcinoma (SCC).MethodsOne hundred twenty‐three patients with T4a oral cavity SCCs underwent surgical treatment. The volumes of the primary cancer were calculated by the multiplication of 3 macroscopic dimensions of the surgical specimen and related to recurrence and death.ResultsThere were 54 recurrences (43.9%) and 75 deaths (60.9%). The mean tumor volume among the patients living without disease during the follow‐up period was 28.2 cc, compared to 88.2 cc for patients living with disease, and to 78.9 cc for patients who died of the disease (p < .001). Multivariate analyses showed that volume and perineural invasion were independent factors for recurrence, whereas volume and lymph node metastasis were independent factors for death.ConclusionAmong patients who already have advanced cancers, tumor volume can significantly impact their prognoses. © 2017 Wiley Periodicals, Inc. Head Neck 39: 960–964, 2017
Remixing My Life: The Multimodal Literacy Memoir Assignment andSTEM
Authors: Pytash Kristine E. , Kist William , Testa Elizabeth 
Published: March 2017

AbstractThe authors explore the experiences and multimodal compositions of a student at aSTEM(science, technology, engineering, and mathematics) high school who opted to take an elective course on multimodal autobiography. They document how her meaning making included her beliefs and perspectives about the world, as well as a finely developed aesthetic sense.
ADCtotal ratio and D ratio derived from intravoxel incoherent motion early after TACE are independent predictors for survival in hepatocellular carcinoma
Authors: Wu Lifang , Xu Pengju , Rao Shengxiang , Yang Li , Chen Caizhong , Liu Hao , Fu Caixia , Zeng Mengsu 
Published: March 2017

PurposeTo explore the threshold of intravoxel incoherent motion (IVIM) parameters, apparent diffusion coefficient [ADCtotal and ADC(0,500)] ratios 24–48 hours after transarterial chemoembolization (TACE) to assess early response in patients with unresectable hepatocellular carcinoma (HCC) and to compare the association between diffusion‐weighted imaging with the intravoxel incoherent motion (IVIM‐DWI) and mRECIST with survival.Materials and MethodsInstitutional Review Board approval and informed consent were obtained for this prospective study. There were 30 patients undergoing 1.5T magnetic resonance imaging (MRI) with IVIM‐DWI of 12 b values (0, 10, 20, 30, 40, 50, 70, 100, 200, 300, 500, 800 s/mm2) 1 week before and 24–48 hours after TACE. Response was assessed with the change of true diffusion coefficient (D), pseudo‐diffusion coefficient (D*), perfusion fraction (PF), ADCtotal, and ADC(0,500) values relative to baseline and with mRECIST. Receiver operating characteristic (ROC) curve analysis was used to explore the threshold of these parameters ratios. Kaplan–Meier, log‐rank tests, and the Cox hazard model were used to correlate the response variables with progression‐free survival (PFS) and to assess the incidence and potential clinical risk factors for PFS. Mann–Whitney U‐test was used to compare the difference in parameters between different groups with progression within and beyond median PFS prior to TACE.ResultsMedian PFS was 99 days, within which 16 patients progressed. The threshold of ADCtotal ratio, D ratio, and ADC(0,500) ratio were 13.1% (P = 0.001), 7.0% (P = 0.011), and 3.6% (P = 0.018) with sensitivity and specificity of 78.6% and 87.5%, 85.7% and 62.5%, 78.6% and 75%, respectively. The predictive utility of ADCtotal ratio, D ratio, and ADC(0,500) ratio for PFS were 0.848, 0.772, and 0.754, respectively. Survival analyses showed ADCtotal ratio, D ratio, ADC(0,500) ratio, liver cirrhosis, and mRECIST had a significant effect on PFS (P < 0.05). ADCtotal ratio and D ratio were independent predictors for 99‐day PFS (P = 0.025, P = 0.036). There were no significant differences in pretreatment IVIM‐DWI parameters between PFS > 99‐day group and PFS ≤ 99‐day group with P values of 0.547 for D, 0.394 for D*, 0.575 for PF, 0.901 for ADC(0,500), and 0.506 for ADCtotal, respectively.ConclusionThe ADCtotal ratio and D ratio 24–48 hours after TACE were independent predictors for response to TACE for HCC, and showed stronger association with PFS than mRECIST.Level of Evidence: 1Technical Efficacy: Stage 2J. MAGN. RESON. IMAGING 2017;46:820–830
Evaluating the freezing impact on the proximate composition of immature cowpea (Vigna unguiculata L.) pods: classical versus spectroscopic approaches
Authors: Machado Nelson , Oppolzer David , Ramos Ana , Ferreira Luis , Rosa Eduardo AS , Rodrigues Miguel , Domínguez‐Perles Raúl , Barros Ana IRNA 
Published: March 2017

AbstractBACKGROUNDFreezing represents a common conservation practice regarding vegetal foodstuffs. Since compositional features need to be monitored during storage, the development of rapid monitoring tools suitable for assessing nutritional characteristics arises as a pertinent issue. In this study, cowpea (Vigna unguiculata L.) pods, both fresh and after 6 and 9 months of freezing at −18 °C, were evaluated by high‐performance liquid chromatography for their content of protein as well as of essential and nonessential amino acids, while their Fourier transform infrared spectra in the mid infrared (MIR) and near infrared (NIR) ranges were concomitantly registered to assess the feasibility of this approach for the traceability of these frozen matrices.RESULTSFor the NIR interval, the application of the 1st derivative to the spectral data retrieved the best results, while for lower concentrations the application of the Savitzky–Golay algorithm was indispensable to achieve quantification models for the amino acids. MIR is also suitable for this purpose, though being unable to quantify amino acids with concentrations below 0.07 mmol g−1 dry weight, irrespective of the data treatment used.CONCLUSIONSThe spectroscopic approach constitutes a methodology suitable for monitoring the impact of freezing on the nutritional properties of cowpea pods, allowing accurate quantification of the protein and amino acid contents, while NIR displayed better performance. © 2017 Society of Chemical Industry
On‐chip laser processing for the development of multifunctional microfluidic chips
Authors: Wang Huan , Zhang Yong‐Lai , Wang Wei , Ding Hong , Sun Hong‐Bo 
Published: March 2017

AbstractIn the development of microfluidic chips, conventional 2D processing technologies contribute to the manufacturing of basic microchannel networks. Nevertheless, in the pursuit of versatile microfluidic chips, flexible integration of multifunctional components within a tiny chip is still challenging because a chip containing micro‐channels is a non‐flat substrate. Recently, on‐chip laser processing (OCLP) technology has emerged as an appealing alternative to achieve chip functionalization through in situ fabrication of 3D microstructures. Here, the recent development of OCLP‐enabled multifunctional microfluidic chips, including several accessible photochemical/photophysical schemes, and photosensitive materials permiting OCLP, is reviewed. To demonstrate the capability of OCLP technology, a series of typical micro‐components fabricated using OCLP are introduced. The prospects and current challenges of this field are discussed.
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Online Display Advertising: The Influence of Web Site Type on Advertising Effectiveness
Authors: Auschaitrakul Sumitra , Mukherjee Ashesh 
Published: March 2017

ABSTRACTThis research shows that online display advertising is more effective in terms of attitudes toward the ad and brand when it appears on commercial Web sites such as Walmart or Amazon, compared to social Web sites such as LinkedIn or Facebook. Consistent with a fit‐fluency mechanism, this effect of Web site type on advertising effectiveness was found to be driven by higher feelings of processing fluency on commercial compared to social Web sites. Further consistent with a fit‐fluency framework, online display advertising was found to be more effective on brand compared to personal pages of social Web sites. These results contribute to the literature on Internet advertising by identifying Web site type as a new antecedent and fit‐fluency as a new mechanism underlying the effectiveness of online display advertising.
Sustainability as a Measure of Success: Externally Promoted Participatory Budgeting in El Salvador 10 Years Later
Authors: Bland Gary 
Published: March 2017

SummaryThis article examines the sustainability of externally promoted participatory budgeting (PB) over more than a decade and, given the results, considers the implications for participatory practice in international development. In 2009, I investigated the continued utilization of PB as introduced through a US‐financed local government development project in post‐war El Salvador. I examined all 28 project municipalities 5 years after the project ended and found limited but important PB sustainability. In 2015, I replicated the study, using the same parameters in the same 28 municipalities, more than 10 years after completion of the project. This article presents the findings of the latter study and compares them with 2009 results. PB continues to be utilized in more than half of the 28 municipalities examined—a striking example of long‐term sustainability—although there is also little continuity of use among individual municipal governments. I conclude that PB is becoming institutionalized, in part because of the initial project. This case of sustainability and institutionalization of PB may allow us to be more optimistic about the potential effects of participation in international development. Copyright © 2017 John Wiley & Sons, Ltd.
Mn-rich Ilmenites in Dyke Rocks – Potential Diamondiferous Occurrence in Malanjkhand Porphyry Copper Mine, Madhya Pradesh
Authors: Nehru C. E. , Sikka D. B. 
Published: March 2017

ABSTRACT
Mn-rich ilmenites (up to 7 % MnO) have been identified in dykes cutting the Malanjkhand porphyry copper mining area in Madhya Pradesh. The dykes are hydrothermally altered and are of tholeiitic affinities. Lamprophyres have been reported from nearby areas. The presence of Mn-rich Ilmenites in the Malanjkhand copper mine dykes and the occurrence of lampro-phyres and the pervasive potassium metasomatism in the area strongly suggests a possibility of finding diamondiferous rocks in the area. Such high-Mn bearing ilmenites are associated with diamondiferous deposits in other parts of the world, e.g. Juina kimberlites, Brazil. Mn-bearing ilmenite is considered as an indicator mineral for kimberlite/diamond occurrences. The presence of kimberlite pipes in Raipur district and the association of Mn-rich ilmenite with kimberlites is a fortuitous coincidence for venture-some mining companies. A probable explanation for the origin of manganese layers in the context of ‘rift’ tectonic environment is offered. Also a possible link between the dykes, quartz veins in the Malanjkhand granitic rocks and the copper mineralization is proposed.
Stability Investigation of Hill Cut Soil Slopes along National Highway 222 at Malshej Ghat, Maharashtra
Authors: Sharma L. K. , Umrao Ravi Kumar , Singh Rajesh , Ahmad M. , Singh T. N. 
Published: March 2017

ABSTRACT
The section of about 12 km of National highway 222 passing through the Malshej Ghat experience frequent slope failure due to complex geological condition, heavy rainfall and slope geometry. The area is part of Western Ghat Deccan trap and slope masses are made of basalt and its weathered crust (debris/soil). The soil slope failure problem mainly occur in rainy seasons due to induced pore water pressure and reduced strength of the slope mass. The present study has been carried out to investigate the slope forming material and assess the stability of soil slopes by numerical approach. For the identification of the vulnerable zones, field study has been carried out and five vulnerable soil slopes identified namely MGS1, MGS2, MGS3, MGS4 and MGS5 on the basis of degree of weathering and slope geometry. The laboratory experiments were carried out to determine the strength properties of the geomaterials. All the input variables acquired from the field and laboratory experiments have been used for numerical simulation, which was performed with the help of limit equilibrium method (LEM) and finite element method (FEM). Numerical analysis provides understanding of the slope behaviour and illustrates that MGS1 and MGS3 are stable slopes, MGS2 and MGS4 are critically stable, whereas, slope MGS5 is unstable. This study recommend the protection of soil slopes and suggest that more detailed investigation is required for long term remedial measures to prevent risk of damage in Malshej Ghat.