bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinematics of SNRs CTB 109 and G206.9+2.3
Authors: Rosado Margarita , Sánchez-Cruces Mónica , Ambrocio-Cruz Patricia 
Published: July 2017

AbstractWe present results of optical observations in the lines of Hα and [SII] (λ 6717 and 6731 Å) obtained with the UNAM Scanning Fabry-Perot Interferometer PUMA (Rosado et al. 1995,RMxAASC, 3, 263 ) aimed at obtaining the kinematical distance, shock velocity and other important parameters of two supernova remnants (SNRs) with optical counterparts. We discuss on how kinematical distances thus obtained fit with other distance determinations. The studied SNRs are CTB 109 (SNR G109.1 − 1.0) hosting a magnetar (Sánchez-Cruces et al. 2017, in preparation) and the SNR G206.9 + 2.3 (Ambrocio-Cruz et al. 2014,RMxAA, 50, 323), a typical supernova remnant, to have a comparison. In Fig. 1 is depicted the [SII] line emission of two filaments of the optical counterpart of SNR CTB 109. We find complex radial velocity profiles obtained with the Fabry-Perot interferometer, revealing the presence of different velocity components. From these velocity profiles we obtain the kinematical distance, an expansion velocity of 188 km/s and an initial energy of 8.1 x 1050 ergs. These values are rather typical of other SNRs regardless that SNR CTB 109 hosts a magnetar. Thus, the mechanical energy delivered in the supernova explosion forming the magnetar does not seem to impact more than other SNe explosions the interstellar medium. This work has been funded by grants IN103116 and 253085 from DGAPA-UNAM and CONACYT, respectively.
New Insights into the Puzzling P-Cygni Profiles of Magnetic Massive Stars
Authors: Erba Christiana , David-Uraz Alexandre , Petit Véronique , Owocki Stanley P. 
Published: July 2017

AbstractMagnetic massive stars comprise approximately 10% of the total OB star population. Modern spectropolarimetry shows these stars host strong, stable, large-scale, often nearly dipolar surface magnetic fields of 1 kG or more. These global magnetic fields trap and deflect outflowing stellar wind material, forming an anisotropic magnetosphere that can be probed with wind-sensitive UV resonance lines. Recent HST UV spectra of NGC 1624-2, the most magnetic O star observed to date, show atypically unsaturated P-Cygni profiles in the Civ resonant doublet, as well as a distinct variation with rotational phase. We examine the effect of non-radial, magnetically-channeled wind outflow on P-Cygni line formation, using a Sobolev Exact Integration (SEI) approach for direct comparison with HST UV spectra of NGC 1624-2. We demonstrate that the addition of a magnetic field desaturates the absorption trough of the P-Cygni profiles, but further efforts are needed to fully account for the observed line profile variation. Our study thus provides a first step toward a broader understanding of how strong magnetic fields affect mass loss diagnostics from UV lines.
SN 2015bh: an LBV becomes NGC 2770s fourth SN. . . or not?
Authors: Thöne Christina C. , de Ugarte Postigo Antonio , Leloudas Giorgos 
Published: July 2017

AbstractMassive stars in the final phases of their lives frequently expel large amounts of material. An interesting example is SN 2009ip that varied in brightness years before its possible core-collapse. Here we present SN 2015bh in NGC 2770 that shows striking similarities to SN 2009ip. It experienced frequent variabilities for 21 years before a smaller precursor and the “main event” in May 2015. Its spectra are consistent with an LBV during the outburst phase and show a complex P-Cygni profile during the main event. Both SN 2009ip and 2015bh were always situated red-wards of LBVs in outburst in the HR diagram. Their final fate is currently still uncertain, SN 2009ip, however, is now fainter than in pre-explosion observations. If the star survives this event it is undoubtedly altered, and we suggest that these “zombie stars” could be LBVs evolving into a Wolf-Rayet (WR) star over a very short timescale.
360-degree videos: a new visualization technique for astrophysical simulations
Authors: Russell Christopher M. P. 
Published: July 2017

Abstract360-degree videos are a new type of movie that renders over all 4π steradian. Video sharing sites such as YouTube now allow this unique content to be shared via virtual reality (VR) goggles, hand-held smartphones/tablets, and computers. Creating 360° videos from astrophysical simulations is not only a new way to view these simulations as you are immersed in them, but is also a way to create engaging content for outreach to the public. We present what we believe is the first 360° video of an astrophysical simulation: a hydrodynamics calculation of the central parsec of the Galactic centre. We also describe how to create such movies, and briefly comment on what new science can be extracted from astrophysical simulations using 360° videos.
Stellar wind measurements for Colliding Wind Binaries using X-ray observations
Authors: Sugawara Yasuharu , Maeda Yoshitomo , Tsuboi Yohko 
Published: July 2017

AbstractWe report the results of the stellar wind measurement for two colliding wind binaries. The X-ray spectrum is the best measurement tool for the hot postshock gas. By monitoring the changing of the the X-ray luminosity and column density along with the orbital phases, we derive the mass-loss rates of these stars.
Exposure to parental psychopathology and offspring's risk of suicide-related thoughts and behaviours: a systematic review
Authors: Goodday S. M. , Shuldiner J. , Bondy S. , Rhodes A. E. 
Published: July 2017

Aims.The primary objective of this systematic review was to identify and synthesise analytic studies examining the association between exposure to parental psychopathology in childhood and the nature of subsequent suicide-related thoughts (SRT) and suicide-related behaviour (SRB) (severity of ideation, planned/unplanned attempts/lethality) and to describe the direction, and magnitude of associations. The secondary objective was to determine if the associations from the primary objective differ by the type(s) and timing of parental psychopathology, sex/gender of the parent and child and is mediated by child psychiatric symptoms and family functioning.Methods.A systematic review was conducted using guidelines from the PRISMA statement. MEDLINE, CINAHL, EMBASE, psycINFO, Web of Science and grey literature sources were searched by two reviewers to March, 2017. Studies were included if they examined any parental psychopathology (Diagnostic and Statistical Manual of Mental Disorders criteria or equivalent) or SRT or SRB and offspring SRT or SRB occurring from birth <25 years of age.Results.Out of 10 231 studies identified, 54 were included for review. Studies were clinically and methodologically heterogeneous with none at low risk of bias (ROB). Nine studies with moderate ROB indicated a significantly increased risk of offspring SRT, suicide attempts (SA) and suicide among those exposed to maternal SA and suicide in childhood or adolescence. In the remaining 45 studies with higher ROB this association persisted. Several studies (67%) did not confirm that the exposure occurred in the offspring's childhood or adolescence. Findings were suggestive of a mediating effect of offspring psychiatric symptoms, however, few studies examined mediation and effect modification of contextual variables.Conclusions.Offspring exposed to maternal SA are at an increased risk of these same behaviours early in life. Prospective attention to the types and timing of maternal and paternal psychopathology and the intermediate pathways to offspring SRT and SRB onset is needed and could have implications for informing modifiable targets for early intervention and prevention.
Emerging paradigm of virtual-microscopy for histopathology diagnosis: survey of US and Canadian oral pathology trainees
Authors: Nwizu Ngozi N , Owosho Adepitan , Ogbureke Kalu U E 
Published: July 2017

Abstract
Objectives/Aims:
The application of virtual microscopy (VM) to research, pre-doctoral medical and dental educational training, and diagnostic surgical and anatomic pathology is well-documented but its application to the field of oral and maxillofacial pathology has not been explored. This is the first study to evaluate the enthusiasm and readiness of US-/Canada-based oral and maxillofacial pathology (OMFP) residents toward employing VM use over conventional microscopy (CM) for diagnostic purposes.

Materials and Methods:
All 46 current US-/Canada-based OMFP residents were invited to participate in an anonymous electronic survey via ‘Survey Monkey’ in 2015. The survey comprised sixteen multiple choice questions and two ‘free text’ questions.

Results:
14% of respondents of the 22 (48%) respondents who completed the survey indicated a willingness to substitute CM with VM in <5 years, and 33% within 10 years. 52% reported they would never substitute CM with VM. Approximately 10 and 57% of respondents thought VM will become an acceptable sole diagnostic tool in most centers within 5 and 10 years, respectively. These findings are irrespective of the fact that overall, 90% of respondents reported being familiar with VM use.

Discussion:
VM technology is unlikely to substitute CM in diagnostic oral and maxillofacial histopathology practice among future OMFP practitioners in the foreseeable future.
WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
Authors: Janczar Szymon , Nautiyal Jaya , Xiao Yi , Curry Edward , Sun Mingjun , Zanini Elisa , Paige Adam JW , Gabra Hani 
Published: July 2017

AbstractThere are clear gaps in our understanding of genes and pathways through which cancer cells facilitate survival strategies as they become chemoresistant. Paclitaxel is used in the treatment of many cancers, but development of drug resistance is common. Along with being an antimitotic agent paclitaxel also activates endoplasmic reticulum (ER) stress. Here, we examine the role of WWOX (WW domain containing oxidoreductase), a gene frequently lost in several cancers, in mediating paclitaxel response. We examine the ER stress-mediated apoptotic response to paclitaxel in WWOX-transfected epithelial ovarian cancer (EOC) cells and following siRNA knockdown of WWOX. We show that WWOX-induced apoptosis following exposure of EOC cells to paclitaxel is related to ER stress and independent of the antimitotic action of taxanes. The apoptotic response to ER stress induced by WWOX re-expression could be reversed by WWOX siRNA in EOC cells. We report that paclitaxel treatment activates both the IRE-1 and PERK kinases and that the increase in paclitaxel-mediated cell death through WWOX is dependent on active ER stress pathway. Log-rank analysis of overall survival (OS) and progression-free survival (PFS) in two prominent EOC microarray data sets (Tothill and The Cancer Genome Atlas), encompassing ~800 patients in total, confirmed clinical relevance to our findings. High WWOX mRNA expression predicted longer OS and PFS in patients treated with paclitaxel, but not in patients who were treated with only cisplatin. The association of WWOX and survival was dependent on the expression level of glucose-related protein 78 (GRP78), a key ER stress marker in paclitaxel-treated patients. We conclude that WWOX sensitises EOC to paclitaxel via ER stress-induced apoptosis, and predicts clinical outcome in patients. Thus, ER stress response mechanisms could be targeted to overcome chemoresistance in cancer.
Biogeography and organic matter removal shape long-term effects of timber harvesting on forest soil microbial communities
Authors: Wilhelm Roland C , Cardenas Erick , Maas Kendra R , Leung Hilary , McNeil Larisa , Berch Shannon , Chapman William , Hope Graeme , Kranabetter J M , Dubé Stephane , Busse Matt , Fleming Robert , Hazlett Paul , Webster Kara L , Morris David , Scott D Andrew , Mohn William W 
Published: July 2017

AbstractThe growing demand for renewable, carbon-neutral materials and energy is leading to intensified forest land-use. The long-term ecological challenges associated with maintaining soil fertility in managed forests are not yet known, in part due to the complexity of soil microbial communities and the heterogeneity of forest soils. This study determined the long-term effects of timber harvesting, accompanied by varied organic matter (OM) removal, on bacterial and fungal soil populations in 11- to 17-year-old reforested coniferous plantations at 18 sites across North America. Analysis of highly replicated 16 S rRNA gene and ITS region pyrotag libraries and shotgun metagenomes demonstrated consistent changes in microbial communities in harvested plots that included the expansion of desiccation- and heat-tolerant organisms and decline in diversity of ectomycorrhizal fungi. However, the majority of taxa, including the most abundant and cosmopolitan groups, were unaffected by harvesting. Shifts in microbial populations that corresponded to increased temperature and soil dryness were moderated by OM retention, which also selected for sub-populations of fungal decomposers. Biogeographical differences in the distribution of taxa as well as local edaphic and environmental conditions produced substantial variation in the effects of harvesting. This extensive molecular-based investigation of forest soil advances our understanding of forest disturbance and lays the foundation for monitoring long-term impacts of timber harvesting.
Drought and host selection influence bacterial community dynamics in the grass root microbiome
Authors: Naylor Dan , DeGraaf Stephanie , Purdom Elizabeth , Coleman-Derr Devin 
Published: July 2017

Abstract
Root endophytes have been shown to have important roles in determining host fitness under periods of drought stress, and yet the effect of drought on the broader root endosphere bacterial community remains largely uncharacterized. In this study, we present phylogenetic profiles of bacterial communities associated with drought-treated root and rhizosphere tissues of 18 species of plants with varying degrees of drought tolerance belonging to the Poaceae family, including important crop plants. Through 16S rRNA gene profiling across two distinct watering regimes and two developmental time points, we demonstrate that there is a strong correlation between host phylogenetic distance and the microbiome dissimilarity within root tissues, and that drought weakens this correlation by inducing conserved shifts in bacterial community composition. We identify a significant enrichment in a wide variety of Actinobacteria during drought within the roots of all hosts, and demonstrate that this enrichment is higher within the root than it is in the surrounding environments. Furthermore, we show that this observed enrichment is the result of an absolute increase in Actinobacterial abundance and that previously hypothesized mechanisms for observed enrichments in Actinobacteria in drought-treated soils are unlikely to fully account for the phenomena observed here within the plant root.
Ice nucleation active bacteria in precipitation are genetically diverse and nucleate ice by employing different mechanisms
Authors: Failor K C , Schmale D G , Vinatzer B A , Monteil C L 
Published: July 2017

Abstract
A growing body of circumstantial evidence suggests that ice nucleation active (Ice+) bacteria contribute to the initiation of precipitation by heterologous freezing of super-cooled water in clouds. However, little is known about the concentration of Ice+ bacteria in precipitation, their genetic and phenotypic diversity, and their relationship to air mass trajectories and precipitation chemistry. In this study, 23 precipitation events were collected over 15 months in Virginia, USA. Air mass trajectories and water chemistry were determined and 33 134 isolates were screened for ice nucleation activity (INA) at −8 °C. Of 1144 isolates that tested positive during initial screening, 593 had confirmed INA at −8 °C in repeated tests. Concentrations of Ice+ strains in precipitation were found to range from 0 to 13 219 colony forming units per liter, with a mean of 384±147. Most Ice+ bacteria were identified as members of known and unknown Ice+ species in the Pseudomonadaceae, Enterobacteriaceae and Xanthomonadaceae families, which nucleate ice employing the well-characterized membrane-bound INA protein. Two Ice+ strains, however, were identified as Lysinibacillus, a Gram-positive genus not previously known to include Ice+ bacteria. INA of the Lysinibacillus strains is due to a nanometer-sized molecule that is heat resistant, lysozyme and proteinase resistant, and secreted. Ice+ bacteria and the INA mechanisms they employ are thus more diverse than expected. We discuss to what extent the concentration of culturable Ice+ bacteria in precipitation and the identification of a new heat-resistant biological INA mechanism support a role for Ice+ bacteria in the initiation of precipitation.
Long-range transport of airborne microbes over the global tropical and subtropical ocean
Authors: Mayol Eva , Arrieta Jesús M. , Jiménez Maria A. , Martínez-Asensio Adrián , Garcias-Bonet Neus , Dachs Jordi , González-Gaya Belén , Royer Sarah-J. , Benítez-Barrios Verónica M. , Fraile-Nuez Eugenio , Duarte Carlos M. 
Published: July 2017

AbstractThe atmosphere plays a fundamental role in the transport of microbes across the planet but it is often neglected as a microbial habitat. Although the ocean represents two thirds of the Earth’s surface, there is little information on the atmospheric microbial load over the open ocean. Here we provide a global estimate of microbial loads and air-sea exchanges over the tropical and subtropical oceans based on the data collected along the Malaspina 2010 Circumnavigation Expedition. Total loads of airborne prokaryotes and eukaryotes were estimated at 2.2 × 1021 and 2.1 × 1021 cells, respectively. Overall 33–68% of these microorganisms could be traced to a marine origin, being transported thousands of kilometres before re-entering the ocean. Moreover, our results show a substantial load of terrestrial microbes transported over the oceans, with abundances declining exponentially with distance from land and indicate that islands may act as stepping stones facilitating the transoceanic transport of terrestrial microbes.
Molecular characterization of breast cancer CTCs associated with brain metastasis
Authors: Boral Debasish , Vishnoi Monika , Liu Haowen N. , Yin Wei , Sprouse Marc L. , Scamardo Antonio , Hong David S. , Tan Tuan Z. , Thiery Jean P. , Chang Jenny C. , Marchetti Dario 
Published: July 2017

AbstractThe enumeration of EpCAM-positive circulating tumor cells (CTCs) has allowed estimation of overall metastatic burden in breast cancer patients. However, a thorough understanding of CTCs associated with breast cancer brain metastasis (BCBM) is necessary for early identification and evaluation of treatment response to BCBM. Here we report that BCBM CTCs is enriched in a distinct sub-population of cells identifiable by their biomarker expression and mutational content. Deriving from a comprehensive analysis of CTC transcriptomes, we discovered a unique “circulating tumor cell gene signature” that is distinct from primary breast cancer tissues. Further dissection of the circulating tumor cell gene signature identified signaling pathways associated with BCBM CTCs that may have roles in potentiating BCBM. This study proposes CTC biomarkers and signaling pathways implicated in BCBM that may be used either as a screening tool for brain micro-metastasis detection or for making rational treatment decisions and monitoring therapeutic response in patients with BCBM.
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
Authors: Raza Syed Ahsan , Albrecht Anne , Çalışkan Gürsel , Müller Bettina , Demiray Yunus Emre , Ludewig Susann , Meis Susanne , Faber Nicolai , Hartig Roland , Schraven Burkhart , Lessmann Volkmar , Schwegler Herbert , Stork Oliver 
Published: July 2017

AbstractCholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.
Discovering the building blocks of atomic systems using machine learning: application to grain boundaries
Authors: Rosenbrock Conrad W. , Homer Eric R. , Csányi Gábor , Hart Gus L. W. 
Published: July 2017

AbstractMachine learning has proven to be a valuable tool to approximate functions in high-dimensional spaces. Unfortunately, analysis of these models to extract the relevant physics is never as easy as applying machine learning to a large data set in the first place. Here we present a description of atomic systems that generates machine learning representations with a direct path to physical interpretation. As an example, we demonstrate its usefulness as a universal descriptor of grain boundary systems. Grain boundaries in crystalline materials are a quintessential example of a complex, high-dimensional system with broad impact on many physical properties including strength, ductility, corrosion resistance, crack resistance, and conductivity. In addition to modeling such properties, the method also provides insight into the physical “building blocks” that influence them. This opens the way to discover the underlying physics behind behaviors by understanding which building blocks map to particular properties. Once the structures are understood, they can then be optimized for desirable behaviors.
Structural Basis for the Mechanism of ATP-Dependent Acetone Carboxylation
Authors: Mus Florence , Eilers Brian J. , Alleman Alexander B. , Kabasakal Burak V. , Wells Jennifer N. , Murray James W. , Nocek Boguslaw P. , DuBois Jennifer L. , Peters John W. 
Published: July 2017

AbstractMicroorganisms use carboxylase enzymes to form new carbon-carbon bonds by introducing carbon dioxide gas (CO2) or its hydrated form, bicarbonate (HCO3−), into target molecules. Acetone carboxylases (ACs) catalyze the conversion of substrates acetone and HCO3− to form the product acetoacetate. Many bicarbonate-incorporating carboxylases rely on the organic cofactor biotin for the activation of bicarbonate. ACs contain metal ions but not organic cofactors, and use ATP to activate substrates through phosphorylation. How the enzyme coordinates these phosphorylation events and new C-C bond formation in the absence of biotin has remained a mystery since these enzymes were discovered. The first structural rationale for acetone carboxylation is presented here, focusing on the 360 kDa (αβγ)2 heterohexameric AC from Xanthobacter autotrophicus in the ligand-free, AMP-bound, and acetate coordinated states. These structures suggest successive steps in a catalytic cycle revealing that AC undergoes large conformational changes coupled to substrate activation by ATP to perform C-C bond ligation at a distant Mn center. These results illustrate a new chemical strategy for the conversion of CO2 into biomass, a process of great significance to the global carbon cycle.