bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the Tendoscopic Modified Das De Procedure for Recurrent Peroneal Tendon Dislocation
Authors: Nishimura Akinobu , Nakazora Shigeto , Ito Naoya , Sudo Akihiro , Kato Ko 
Published: October 2016

Category: Sports Introduction/Purpose: Traumatic peroneal tendon dislocation is an uncommon lesion that mainly affects young adults. It occurs most frequently during sports activities and generally during an ankle sprain. Unfortunately, most cases lead to recurrent peroneal tendon dislocation (RPTD). Therefore, most cases need operative treatments. Many surgical techniques for the treatment of RPTD have been described. One of the most popular operative procedures is the modified Das De procedure, which is the superior peroneal retinaculum (SPR) repair. Since 2014, we have performed the procedure along with tendoscopy. The purpose of this study is a preliminary report on the tendoscopic modified Das De procedure. Methods: We performed surgery for RPTD in 5 consecutive patients (4 men and 1 woman, mean age 21.4 years). All the patients were injured during sports activities. This procedure was performed with the patient in the lateral decubitus position. Two portals were made. Three anchors were inserted in the fibula. An 18-gauge needle, into which a shuttle relay had been looped (2-0 Prolene), was used to thread through the SPR. Six passes were made (Image), and the sutures were tightened in order to reattach the SPR to the fibula. A knotless anchor was screwed into the lateral aspect of the fibula to allow for suturing by using the bridge technique. For postoperative care, a short-leg cast was applied for 3 weeks. The patients were allowed partial and full weight bearing at 2 and 3 weeks, respectively. Evaluation parameters included the operation time, complications, return to regular sports activities, and recurrence. Results: The mean operation time was 88.8 minutes (range: 69–125 minutes), which was relatively longer than that of our previous open modified Das de procedure (mean: 40.0 minutes). However, compared with the initial cases, recent cases tended to have shorter surgical times. No complications occurred. All the patients could return to regular sports activities within 4 months after surgery. No recurrence was observed during the follow-up period (mean: 11.4 months; range: 9–14 months). Conclusion: The tendoscopic modified Das De procedure for RPTD required a longer operation time compared to open surgeries. However, the operation time is expected to be shortened as the surgeon gains experience. In addition, this procedure was not associated with any early severe complications and allowed patients to return to sports activities within a short period. Long-term studies involving a large number of cases are needed. However, this procedure is an attractive option because it is less invasive and has achieved similar results as those in open procedures.
Neuroinflammatory and morphological changes in late-life
depression: the NIMROD study
Authors: Su Li , Faluyi Yetunde O. , Hong Young T. , Fryer Tim D. , Mak Elijah , Gabel Silvy , Hayes Lawrence , Soteriades Soteris , Williams Guy B. , Arnold Robert , Passamonti Luca , Rodríguez Patricia Vázquez , Surendranathan Ajenthan , Bevan-Jones Richard W. , Coles Jonathan , Aigbirhio Franklin , Rowe James B. , O'Brien John T. 
Published: October 2016

SummaryWe studied neuroinflammation in individuals with late-life, depression, as a
risk factor for dementia, using [11C]PK11195 positron emission
tomography (PET). Five older participants with major depression and 13
controls underwent PET and multimodal 3T magnetic resonance imaging (MRI),
with blood taken to measure C-reactive protein (CRP). We found significantly
higher CRP levels in those with late-life depression and raised
[11C]PK11195 binding compared with controls in brain regions
associated with depression, including subgenual anterior cingulate cortex,
and significant hippocampal subfield atrophy in cornu ammonis 1 and
subiculum. Our findings suggest neuroinflammation requires further
investigation in late-life depression, both as a possible aetiological
factor and a potential therapeutic target.
HEAT repeats – versatile arrays of amphiphilic helices working in crowded environments?
Authors: Yoshimura Shige H. , Hirano Tatsuya 
Published: October 2016

ABSTRACT
Cellular proteins do not work in isolation. Instead, they often function as part of large macromolecular complexes, which are transported and concentrated into specific cellular compartments and function in a highly crowded environment. A central theme of modern cell biology is to understand how such macromolecular complexes are assembled efficiently and find their destinations faithfully. In this Opinion article, we will focus on HEAT repeats, flexible arrays of amphiphilic helices found in many eukaryotic proteins, such as karyopherins and condensins, and discuss how these uniquely designed helical repeats might underlie dynamic protein–protein interactions and support cellular functions in crowded environments. We will make bold speculations on functional similarities between the action of HEAT repeats and intrinsically disordered regions (IDRs) in macromolecular phase separation. Potential contributions of HEAT–HEAT interactions, as well as cooperation between HEATs and IDRs, to mesoscale organelle assembly will be discussed.
ELYS regulates the localization of LBR by modulating its phosphorylation state
Authors: Mimura Yasuhiro , Takagi Masatoshi , Clever Michaela , Imamoto Naoko 
Published: October 2016

ABSTRACT
Lamin B receptor (LBR), an inner nuclear membrane (INM) protein, contributes to the functional integrity of the nucleus by tethering heterochromatin to the nuclear envelope. We have previously reported that the depletion of embryonic large molecule derived from yolk sac (ELYS; also known as AHCTF1), a component of the nuclear pore complex, from cells perturbs the localization of LBR to the INM, but little is known about the underlying molecular mechanism. In this study, we found that the depletion of ELYS promoted LBR phosphorylation at the residues known to be phosphorylated by cyclin-dependent kinase (CDK) and serine/arginine protein kinases 1 and 2 (SRPK1 and SRPK2, respectively). These phosphorylation events were most likely to be counter-balanced by protein phosphatase 1 (PP1), and the depletion of PP1 from cells consistently caused the mislocalization of LBR. These observations point to a new mechanism regulating the localization of LBR, which is governed by an ELYS-mediated phosphorylation network. This phosphorylation-dependent coordination between INM proteins and the nuclear pore complex might be important for the integrity of the nucleus.
Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells
Authors: Zhu Linyu , Xiong Xiahui , Kim Yongsoon , Okada Naomi , Lu Fei , Zhang Hui , Sun Hong 
Published: October 2016

ABSTRACT
Receptor tyrosine kinases (RTKs) are embedded in the lipid bilayer of the plasma membrane, but the specific roles of various lipids in cell signaling remain largely uncharacterized. We have previously found that acid sphingomyelinase (ASM; also known as SMPD1) regulates the conserved DAF-2 (the ortholog IGF-1R in mammals) RTK signaling pathway in Caenorhabditis elegans. How ASM and its catalytic products, ceramides, control RTK signaling pathways remain unclear. Here, we report that ASM regulates the homeostasis of Met, an RTK that is frequently overexpressed in various cancers. Inactivation of ASM led to a rapid loss of Met from the plasma membrane, reduced Met phosphorylation and activation, and induced Met accumulation in the trans-Golgi network (TGN). However, trafficking of integrin β3 and vesicular stomatitis virus glycoprotein (VSVG) was largely unaffected. Knockdown of syntaxin 6 (STX6) also blocked the Golgi exit of Met. Depletion of either ASM or STX6 led to aberrant trafficking of Met to lysosomes, promoting its degradation. Our studies reveal that ASM and ceramides, together with STX6 and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route, which is used to rapidly replenish and regulate the plasma membrane levels of Met in various cancer cells.
Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1
Authors: Espigat-Georger Aude , Dyachuk Vyacheslav , Chemin Cécile , Emorine Laurent , Merdes Andreas 
Published: October 2016

ABSTRACT
Myotubes are syncytial cells generated by fusion of myoblasts. Among the numerous nuclei in myotubes of skeletal muscle fibres, the majority are equidistantly positioned at the periphery, except for clusters of multiple nuclei underneath the motor endplate. The correct positioning of nuclei is thought to be important for muscle function and requires nesprin-1 (also known as SYNE1), a protein of the nuclear envelope. Consistent with this, mice lacking functional nesprin-1 show defective nuclear positioning and present aspects of Emery–Dreifuss muscular dystrophy. In this study, we perform small interfering RNA (siRNA) experiments in C2C12 myoblasts undergoing differentiation, demonstrating that the positioning of nuclei requires PCM-1, a protein of the centrosome that relocalizes to the nuclear envelope at the onset of differentiation in a manner that is dependent on the presence of nesprin-1. PCM-1 itself is required for recruiting proteins of the dynein–dynactin complex and of kinesin motor complexes. This suggests that microtubule motors that are attached to the nuclear envelope support the movement of nuclei along microtubules, to ensure their correct positioning in the myotube.
Non-Hodgkin lymphoma in adults: a guide for practice nurses
Authors: Perry Margaret 
Published: October 2016

Practice nurses have a valuable role to play in instigating earlier diagnosis in patients with possible symptoms of non-Hodgkin lymphoma, and supporting those undergoing treatment, writes Margaret Perry Non-Hodgkin lymphoma is an uncommon cancer that develops in the lymphatic system and accounts for approximately 85% of cancers of this type. This article—part one in a two-part series, the second part of which will consider Hodgkin lymphoma—outlines the causes and possible risk factors for non-Hodgkin lymphoma, diagnosis, treatment and management and prognosis. It aims to provide nurses with insight into the disease, to enhance their knowledge of a complex condition and increase their confidence in treating patients in primary care. Practice nurses can play a vital role in instigating earlier diagnosis and treatment when they encounter patients with suspicious symptoms, and can offer support to those undergoing treatment.
Communicating the importance of pre-exposure rabies vaccination
Authors: Brewer Catherine 
Published: October 2016

Health professionals providing travel advice must understand the purpose and regime of recommendations for pre- and post-rabies exposure and communicate them to travellers, including new guidance from Public Health England, writes Catherine Brewer Rabies is an acute viral encephalomyelitis caused by members of the lyssavirus genus. The rabies virus attacks the central nervous system, resulting in progressive inflammation of the spinal cord and brain ( National Travel Health Network and Centre, 2016 ). Once symptoms develop, rabies is almost always fatal; however, it is vaccine-preventable. Having a full understanding of the gravity of the disease, plus the purpose and regime of the pre- and post-exposure recommendations, and communicating these clearly, will allow travellers to make informed decisions. It is also vital that people know what to do if they have a potential exposure, and receive the correct post-exposure treatment, regardless of their vaccination status.
Diagnosis and management of childhood asthma in primary care
Authors: Lo David , Gaillard Erol , Gaillard Brigitte , Bullous Louise 
Published: October 2016

Diagnosing asthma in children is challenging, but information obtained from clinical history and objective lung function testing should help nurses determine probability and adopt a stepwise approach, write Dr David Lo, Dr Brigitte Gaillard, Louise Bullous and Dr Erol Gaillard Although asthma is the most common non-communicable disease of childhood, there is no standardised definition nor gold-standard test available to diagnose the condition. Asthma is a complex airways disorder where genetic, environmental and host immunity are likely to play a part. Misdiagnosis in children is common, although objective lung function tests aid accuracy, when combined with a clinical history. Adopting a stepwise approach to achieving complete, or good, control of symptoms enhances management and regular treatment reviews should include provision of mutually-agreed, written personalised asthma action plans, which should also be given to children's schools. When control is poor or diagnosis uncertain, patients should be referred to specialist care.
Minería aurífera ilegal en el resguardo indígena alto Andágueda.
Authors: Echeverry Osorio Diana Lorena , Díaz Ricardo Sandra 
Published: October 2016

El resguardo indígena embera katío del río Alto Andágueda está siendo afectado por uno de los problemas nacionales más importantes, denominado minería ilegal, lo cual altera los componentes sociales, culturales, económicos y ambientales de los nativos del lugar y vulnera sus derechos fundamentales. Esto trae como consecuencia la presencia de delitos conexos como extorsión, explotación infantil y violación, entre otros, además de una nefasta destrucción del ambiente, por lo que amerita una revisión de responsabilidades y participación de las entidades comprendidas en las ramas del poder público colombiano para atender la problemática en este resguardo indígena.
A New Hermas Papyrus Fragment in Paris
Authors: Batovici Dan 
Published: October 2016

Abstract
This article offers an edition of P.Weill I 96, containing sections of a 2nd (or late 1st) century AD work, the Shepherd of Hermas. It belongs to the École Pratique des Hautes Études in Paris, but is hosted at the Institut de papyrologie de la Sorbonne. Since it was shown to be part of the same codex leaf as the B fragment of P.Prag. I 1, the Prague fragments are re-edited here as well.
Response to K. Bartol, ‘P.Oxy. LXIV 4410, Fr. 1 and 2.1–5’
Authors: Perale Marco 
Published: October 2016

Abstract
The current note is a response to K. Bartol’s arguments against my readings of P.Oxy. LXIV 4410. It questions her interpretation of fr. 1 and suggests an alternative way of understanding the expression πρόβα κατωτέρω in fr. 1.2.
Catalogue of the Evidence for Presocratics in the Herculaneum Papyri
Authors: Vassallo Christian 
Published: October 2016

Abstract
This article provides the first complete catalogue of the evidence for pre- Socratic philosophers handed down by the Herculaneum papyri. The Index Praesocraticorum Philosophorum Herculanensis (IPPH) aims to lay the foundations for a systematic analysis of the Traditio Praesocratica within Epicureanism. The list of the testimonia is updated to the current state of the research and to the most recent critical reconstructions of each papyrus entailed in such an inquiry.
Automation of the test procedure for accelerated aging of implant packages
Authors: Koker Liane , Nagel Jörg A. , Schulz Bernhard , Ritter Fabian , Vollmannshauser Stefan , Besser Heino , Gengenbach Ulrich 
Published: October 2016

Abstract
An automated accelerated aging test procedure is presented to estimate the lifetime of implant packages regarding
hermeticity. Intruding humidity is captured automatically in packages at two elevated temperatures using a resonant
circuit comprised of capacitive humidity sensor and coil in coupling with an external coil. Described are the test stand
setup including sensor calibration and evaluation, data acquisition and processing. In a first application the safe and
reliable operation of the setup is demonstrated.
Technology Licensing between Rival Firms in Presence of Asymmetric Information
Authors: Sen Neelanjan , Bhattacharya Sukanta 
Published: October 2016

AbstractThis paper investigates the possibility of licensing between rival firms in a Cournot duopoly market. Unlike Heywood, Li, and Ye (2014. “Per Unit vs. Ad Valorem Royalties under Asymmetric Information.” International Journal of Industrial Organization 37:38–46), the cost information of the licensee is private in the pre-licensing stage. If inspection of the licensee’s technology is not possible by the licensor i) technology is never transferred from the low-cost firm (licensor) to the high-cost firm (licensee) via fixed-fee and ii) in the case of royalty licensing technology will be transferred only if the cost difference between the firms is sufficiently high. Moreover, under fixed-fee and royalty licensing, the licensee will always allow the licensor to inspect its technology, if inspection is possible. If inspection is undertaken by the licensor, technology will be transferred i) if the cost difference is low via fixed fee and ii) always via royalty.
Implementing CEFR principles in introductory Norwegian language courses for international students: Opportunities and challenges
Authors: Wapinska Ewa 
Published: October 2016

AbstractThis article describes some of the opportunities and challenges presented by beginners’ courses in Norwegian for international students offered by the Department of Linguistics and Scandinavian Studies at the University of Oslo. Teaching approaches and course content are examined in relation to CEFR levels A1, A2 and B1 and the CEFR’s main objectives. The aim is to invite the reader to share in dynamic and communicative task- and learner-oriented practices, with a particular focus on the benefits of extensive use of the target language – in this case Norwegian. Various target language strategies and activities can be used to adjust and develop concrete context-relevant descriptors in today’s multicultural and multilingual academic environment. Finally, the article shows how to help students and teachers to benefit from good practice and how to apply systematic and sustainable assessment strategies during the initial stages of learning a new language in the host country.
Biografische Methoden der Kompetenzanalyse für die Reflexion von Sprachkompetenz–Portfolioarbeit in der Praxis
Authors: Reil Kirstin 
Published: October 2016

AbstractIm Rahmen von Fremdsprachenunterricht werden unterschiedliche Instrumente eingesetzt, die der Förderung der Selbstreflexion dienen und damit die Kompetenzorientierung fördern (Checklisten, Lerntagebücher etc.). Sie sind Bestandteil der Arbeit mit dem biografischen Teil des Europäischen Sprachenportfolios. Studierende sollen dazu angeregt werden, ihre Sprachkompetenzen benennen und einschätzen zu können und auf dieser Basis ihre Lernziele zu definieren und weitere Lernschritte zu planen. Dabei steht die Handlungsorientierung im Vordergrund.Sprachkompetenzen werden häufig in formalen Lernarrangements erworben. Hierüber können Studierende leicht Auskunft geben, weil die Dauer, der Inhalt und ein (formales) Ergebnis dokumentierbar sind. Ein Großteil der Kompetenzen wird jedoch informell erworben. Um ein genaueres Bild dieser Kompetenzen zu erhalten, bedarf es Unterstützungsformen und Methoden, um Handlungssituationen zu erinnern und zu beschreiben, in denen diese Kompetenzen erworben bzw. angewendet wurden. Der Einsatz entsprechender Methoden im Sprachunterricht bedeutet, informell erworbene Kompetenzen in einer formalen Lernumgebung zu thematisieren und liefert gleichzeitig Möglichkeiten, verschiedene Sprachkompetenzbereiche weiter zu fördern. In diesem Beitrag werden verschiedene biografische Methoden vorgestellt, die im Rahmen des außercurricularen Sprachenprogramms FremdsprachenPlus an der Hochschule Bremen angewendet werden.
The role of second language in higher education: A case study of German students at a Dutch university
Authors: Zijlmans Lidy , Neijt Anneke , van Hout Roeland 
Published: October 2016

AbstractThis article reports on an investigation of the challenges and benefits of university students taking a degree course in a language other than their mother tongue. Our study was conducted from the point of view of the non-native students themselves, and our primary concern was the role of language. We investigated the academic achievement of German students studying in a Dutch-English academic environment. Dutch is the main language of instruction, and English the main language of the literature used. In search of predictors for successful learning of Dutch (our first research question), LexTALE tests were administered to determine linguistic competence in the students’ first language, German, and their second language, English. In addition, we collected data on their educational background and language learning history. None of the LexTALE scores stood out as ‘the’ predictor for success in learning Dutch; German was a slightly better predictor than English. The best predictor appeared to be the students’ general educational level, expressed in mean grades for final exams in secondary education. We then studied the role of proficiency in the foreign languages needed for academic success. Language data on L3 Dutch were gathered at the start and were compared to study results after the first six months and at the end of the first year. The level of Dutch as a second language correlated with study results, expressed in ECTS; the correlation was even higher with mean grades on exams. This indicates that language proficiency does play a role in study success.
Die Trollfrau als kultureller Katalysator in der Illuga saga Gríðarfóstra
Authors: Schäfke Werner 
Published: October 2016

Abstract
This article introduces the model of the semiosphere developed by Yuri Lotman for cultural studies to the study of Icelandic sagas. The semiosphere helps analyzing value systems in such narrative texts. The semiosphere focuses on dynamic processes and thus better fits to describing narrative texts – that by definition contain a dynamic sequence of events – than static structuralist models do.
The analysis of Illuga saga Gríðarfóstra with help of the semiosphere-model shows that the value system of the saga criticizes rigid aristocratic societal structures in favor for a more liberal system, in which the able individual can rise to higher ranks. Furthermore, the saga addresses female sexual morality: women are supposed to be monogamous, and not enjoy sexual intercourse. Illuga saga thus aligns with most value systems found in the Fornaldarsǫgur. However, in contrary to the female passiveness demanded by most Fornaldarsǫgur, Illuga saga welcomes female agency and even aggressiveness.
Conceptual relations in the semantic domain of Swedish dimensional adjectives
Authors: Shimotori Misuzu 
Published: October 2016

Abstract
In the conventional study of lexical semantics, adjectives are not considered likely to have a hierarchical relation, such as a meronymic (part-whole) relation, to each other. The most possible lexical relations among adjectives are antonymy and synonymy. In this study, however, I assume that meronomic relations between internal members of dimensional adjectives (e. g. big, long, deep) are conceptually possible from an ontological point of view. By using a semantic task, i. e. anaphora resolution, I draw the following conclusion: dimensional adjectives themselves have no meronymic relation to each other. However, restricting our discussion to the usage of Swedish dimensional adjectives in modifying concrete entities, the conceptual relations between the general term, e. g. BIG,1I use capital letters to indicate concepts throughout this essay. Lexical items are written in italics. and specific terms, e. g. LONG, DEEP, are mentally organized in a part-whole relation and thus in a meronomic structure. When applied to the whole expression which is a concept of a big entity, such as BIG CUP, there are meronomic relations between concepts of the big entity and its parts, e. g. BIG CUP – DEEP CUP.