bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel high-z submm galaxy efficient line survey in ALMA Bands 3 through 8 – an ANGELS pilot
Authors: Bakx T J L C , Amvrosiadis A , Bendo G J , Algera H S B , Serjeant S , Bonavera L , Borsato E , Chen X , Cox P , González-Nuevo J , Hagimoto M , Harrington K C , Ivison R J , Kamieneski P , Marchetti L , Riechers D A , Tsukui T , van der Werf P P , Yang C , Zavala J A , Andreani P , Berta S , Cooray A R , De Zotti G , Eales S , Ikeda R , Knudsen K K , Mitsuhashi I , Negrello M , Neri R , Omont A , Scott D , Tamura Y , Temi P , Urquhart S A 
Published: October 2024

ABSTRACT
We use the Atacama Large sub/Millimetre Array (ALMA) to efficiently observe spectral lines across Bands 3, 4, 5, 6, 7, and 8 at high-resolution (0.5–0.1 arcsec) for 16 bright southern Herschel sources at $1.5 \lt z \lt 4.2$. With only six and a half hours of observations, we reveal 66 spectral lines in 17 galaxies. These observations detect emission from CO (3−2) to CO(18−17), as well as atomic ([C i](1−0), (2−1), [O i] 145 $\mu$m and [N ii] 205 $\mu$m) lines. Additional molecular lines are seen in emission (${\rm H_2O}$ and ${\rm H_2O^+}$) and absorption (OH$^+$ and CH$^+$). The morphologies based on dust continuum ranges from extended sources to strong lensed galaxies with magnifications between 2 and 30. CO line transitions indicate a diverse set of excitation conditions with a fraction of the sources ($\sim 35$ per cent) showcasing dense, warm gas. The resolved gas to star formation surface densities vary strongly per source, and suggest that the observed diversity of dusty star-forming galaxies could be a combination of lensed, compact dusty starbursts and extended, potentially merging galaxies. The predicted gas depletion time-scales are consistent with 100 Myr to 1 Gyr, but require efficient fuelling from the extended gas reservoirs onto the more central starbursts, in line with the Doppler-shifted absorption lines that indicate inflowing gas for two out of six sources. This pilot paper explores a successful new method of observing spectral lines in large samples of galaxies, supports future studies of larger samples, and finds that the efficiency of this new observational method will be further improved with the planned ALMA Wideband Sensitivity Upgrade.
ExoMol line lists – LXII. Ro-vibrational energy levels and line strengths for the propadienediylidene (C3) in its ground electronic state
Authors: Lynas-Gray A E , Polyansky O L , Tennyson J , Yurchenko S N , Zobov N F 
Published: October 2024

ABSTRACT
Improved opacities are needed for modelling the atmospheres and evolution of cool carbon-rich stars and extra-solar planets; in particular, contributions made by the astrophysically important propadienediylidene (${\mathrm{C}}_{3}$) molecule need, at a minimum, to be determined using a line list which includes all significant transitions in the energy range of interest. We report variational calculations giving ro-vibrational energy levels and corresponding line strengths for $^{12}{\mathrm{C}}_3$, $^{12}{\mathrm{C}}^{13}{\mathrm{C}}^{12}{\mathrm{C}}$, and $^{12}{\mathrm{C}}^{12}{\mathrm{C}}^{13}{\mathrm{C}}$. In the $^{12}{\mathrm{C}}_3$ case, we obtain 2166 503 ro-vibrational state energies $\leqslant$2000 cm−1 for the electronic $\tilde{X}{\, }^{1}{\Sigma _{\rm g}}^{+}$ ground state. Comparison with experiment indicates a maximum error of $\pm 0.03$ ${\rm cm}^{-1}$ in calculated positions of lines involving an upper state energy $\lessapprox$4000 cm−1. For lines with upper state energies $\gtrapprox$4000 cm−1 to have comparable line-position accuracies, conical intersections would need to be accounted for in an adopted potential energy surface. Line lists and associated opacities are provided in the ExoMol data base (http://www.exomol.com).
Aptamer-based assay for high-throughput substrate profiling of RNA decapping enzymes
Authors: Grab Katarzyna , Fido Mateusz , Spiewla Tomasz , Warminski Marcin , Jemielity Jacek , Kowalska Joanna 
Published: October 2024

Abstract
Recent years have led to the identification of a number of enzymes responsible for RNA decapping. This has provided a basis for further research to identify their role, dependency and substrate specificity. However, the multiplicity of these enzymes and the complexity of their functions require advanced tools to study them. Here, we report a high-throughput fluorescence intensity assay based on RNA aptamers designed as substrates for decapping enzymes. Using a library of differently capped RNA probes we generated a decapping susceptibility heat map, which confirms previously reported substrate specificities of seven tested hydrolases and uncovers novel. We have also demonstrated the utility of our assay for evaluating inhibitors of viral decapping enzymes and performed kinetic studies of the decapping process. The assay may accelerate the characterization of new decapping enzymes, enable high-throughput screening of inhibitors and facilitate the development of molecular tools for a better understanding of RNA degradation pathways.
Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks
Authors: Long Qilin , Ajit Kamal , Sedova Katerina , Haluza Vojtech , Stefl Richard , Dokaneheifard Sadat , Beckedorff Felipe , Valencia Monica G , Sebesta Marek , Shiekhattar Ramin , Gullerova Monika 
Published: October 2024

Abstract
DNA double-strand breaks (DSBs) represent a lethal form of DNA damage that can trigger cell death or initiate oncogenesis. The activity of RNA polymerase II (RNAPII) at the break site is required for efficient DSB repair. However, the regulatory mechanisms governing the transcription cycle at DSBs are not well understood. Here, we show that Integrator complex subunit 6 (INTS6) associates with the heterotrimeric sensor of ssDNA (SOSS1) complex (comprising INTS3, INIP and hSSB1) to form the tetrameric SOSS1 complex. INTS6 binds to DNA:RNA hybrids and promotes Protein Phosphatase 2A (PP2A) recruitment to DSBs, facilitating the dephosphorylation of RNAPII. Furthermore, INTS6 prevents the accumulation of damage-associated RNA transcripts (DARTs) and the stabilization of DNA:RNA hybrids at DSB sites. INTS6 interacts with and promotes the recruitment of senataxin (SETX) to DSBs, facilitating the resolution of DNA:RNA hybrids/R-loops. Our results underscore the significance of the tetrameric SOSS1 complex in the autoregulation of DNA:RNA hybrids and efficient DNA repair.
ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells
Authors: Zhu Hongtao , Cheng Lidong , Liu Dan , Ma Xiaoyu , Chen Zhiye , Fan Heng , Li Ran , Zhang Yang , Mi Hailong , Li Jun , Zhang Suojun , Yu Xingjiang , Shu Kai 
Published: October 2024

Abstract

Background
Glioma stem cells (GSCs) are the root cause of tumorigenesis, recurrence, and therapeutic resistance in glioblastoma (GBM), the most prevalent and lethal type of primary adult brain malignancy. The exploitation of novel methods targeting GSCs is crucial for the treatment of GBM. In this study, we investigate the function of the novel ROR1-GRB2-c-Fos axis in GSCs maintenance and GBM progression.

Methods
The expression characteristics of ROR1 in GBM and GSCs were assessed by bioinformatic analysis, patient specimens, and patient-derived GSCs. Lentivirus-mediated gene knockdown and overexpression were conducted to evaluate the effect of ROR1 on GSCs proliferation and self-renewal both in vitro and in vivo. The downstream signaling of ROR1 in GSCs maintenance was unbiasedly determined by RNA-seq and validated both in vitro and in vivo. Finally, rescue assays were performed to further validate the function of the ROR1-GRB2-c-Fos axis in GSCs maintenance and GBM progression.

Results
ROR1 is upregulated in GBM and preferentially expressed in GSCs. Disruption of ROR1 markedly impairs GSC proliferation and self-renewal, and inhibits GBM growth in vivo. Moreover, ROR1 stabilizes GRB2 by directly binding and reducing its lysosomal degradation, and ROR1 knockdown significantly inhibits GRB2/ERK/c-Fos signaling in GSCs. Importantly, ectopic expression of c-Fos counteracts the effects caused by ROR1 silencing both in vitro and in vivo.

Conclusions
ROR1 plays essential roles in GSCs maintenance through binding to GRB2 and activation of ERK/c-Fos signaling, which highlights the therapeutic potential of targeting the ROR1-GRB2-c-Fos axis.
In situ optical feedback in brain tumor biopsy: A multiparametric analysis
Authors: Klint Elisabeth , Richter Johan , Milos Peter , Hallbeck Martin , Wårdell Karin 
Published: October 2024

Abstract

Background
Brain tumor needle biopsy interventions are inflicted with nondiagnostic or biased sampling in up to 25% and hemorrhage, including asymptomatic cases, in up to 60%. To identify diagnostic tissue and sites with increased microcirculation, intraoperative optical techniques have been suggested. The aim of this study was to investigate the clinical implications of in situ optical guidance in frameless navigated tumor biopsies.

Methods
Real-time feedback on protoporphyrin IX (PpIX) fluorescence, microcirculation, and gray-whiteness was given before tissue sampling (272 positions) in 20 patients along 21 trajectories in total. The primary variables of investigation were fluorescence in relation to neuropathological findings and gadolinium (Gd) enhancement, increased cerebral microcirculation in relation to bleeding incidence, number of trajectories, and impact on operation time.

Results
PpIX fluorescence was detected in Glioblastoma IDH-wildtype CNS WHO grade 4 (n = 12), Primary diffuse large B-cell lymphoma (n = 3), astrocytoma IDH-mutated CNS WHO grade 4 (n = 1) (Ki67 indices ≥ 15%). For 2 patients, no PpIX fluorescence or Gd was found, although samples contained tumorous tissue (Ki67 index 6%). Increased microcirculation was found along 9 trajectories (34 sites), located in cortical, tumorous, or tentorium regions. Postoperative bleedings (n = 10, nine asymptomatic) were related to skull opening or tissue sampling. This study strengthens the proposed independence from intraoperative neuropathology as PpIX fluorescence is detected. Objective real-time feedback resulted in fewer trajectories compared to previous studies indicating reduced operation time.

Conclusions
The integrated optical guidance system provides real-time feedback in situ, increasing certainty and precision of diagnostic tissue before sampling during frameless brain tumor biopsies.
Magnetic resonance imaging and o-(2-[18F]fluoroethyl)-l-tyrosine positron emission tomography for early response assessment of nivolumab and bevacizumab in patients with recurrent high-grade astrocytic glioma
Authors: Henriksen Otto Mølby , Maarup Simone , Hasselbalch Benedikte , Poulsen Hans Skovgaard , Christensen Ib Jarle , Madsen Karine , Larsen Vibeke Andrée , Lassen Ulrik , Law Ian 
Published: October 2024

Abstract

Background
In the present study, early response assessment by o-(2-[18F]fluoroethyl)-l-tyrosine (FET) positron emission tomography (PET) and contrast-enhanced magnetic resonance imaging (MRI) were investigated in a phase II open-label single-center study of nivolumab plus bevacizumab for recurrent high-grade astrocytic glioma.

Methods
Twenty patients with nonresectable first recurrence of high-grade astrocytic glioma after EORTC/NCIC protocol underwent [18F]FET PET/MRI at baseline and after 2 cycles of treatment. Whole brain values of contrast-enhancing volume on MRI (CEV), of the mean (TBRmean) and maximal tumor-to-background ratio (TBRmax), and of metabolically active volume (MTV) on [18F]FET PET were obtained. Regional changes in [18F]FET uptake were assessed by parametric response mapping (PRM). Prediction of overall survival (OS) and response (OS &gt; 11 months) were assessed by Cox and receiver operating characteristic (ROC) analysis, respectively. Also, MRI (response assessment in neuro-oncology [RANO] 2.0) and PET-based (PET RANO 1.0) response assessment criteria were compared.

Results
In ROC analysis responders were separated (P &lt; .05) from nonresponders by lower MTV at follow-up (AUC 0.771, cutoff 18.3 mL), larger decrease in MTV (AUC 0.757, cutoff −5.3 mL), larger decrease in both TBRmax (AUC 0.814, cutoff −0.53) and relative TBRmax (AUC 0.829, cutoff −11%) and smaller PRM progressive volume (AUC 0.843, cutoff 4.0 mL). Change in CEV did not predict response. RANO 2.0 and PET RANO response assessment criteria had similar and only borderline prognostic values.

Conclusions
The study indicates that [18F]FET PET is superior to contrast-enhanced MRI for early response assessment in patients with recurrent high-grade astrocytic glioma treated with nivolumab and bevacizumab.
Abomination of Desolation
Authors: deSilva David A. 
Published: October 2024

Abstract
This chapter covers the history of Judea between 187 and 141 bce. It discusses the bold experiment, pioneered by Jerusalem’s elite, of refounding Jerusalem as a Greek city with a Greek constitution; the internal splintering and popular resistance that led to the forced adoption of Greek religious practices and abandonment of Torah observance; the traumatic reconsecration of the Jerusalem Temple to non-Jewish deities; the successful popular revolt led by Judas Maccabeus and his family; and the consolidation of political gains made by Jonathan and Simon, Judas’s surviving brothers, largely thanks to the internecine strife that beset the Seleucid empire after the death of Antiochus IV.
Home Court Advantages
Authors: Thompson Gordon Ross 
Published: October 2024

Abstract
In the competitive environment of midsixties pop, the Rolling Stones, the Who, and the Beatles adapted their music as their audiences matured and expanded. Mick Jagger’s and Keith Richards’s songs began to articulate both Western culture’s deep-seated misogyny and the sexual objectification of women and England’s preoccupation with class. Peter Townshend, with encouragement from manager-producer Kit Lambert, turned his attention from Mods to explore an English style of writing. The result was a series of songs and recordings of growing complexity that tell stories about people in extraordinary circumstances. John Lennon’s early 1966 existential crisis and his use of psychoactive drugs shifted his output to describe the psychedelic experience while Paul McCartney embraced the idea of being a professional songwriter. George Harrison, however, was also developing as a songwriter and wrote songs that criticized the British tax system and incorporated elements of Indian music.
Political Persuasion
Authors: Nelson Thomas E. 
Published: October 2024

Abstract
Values are fundamental to political attitudes. Ideals such as freedom, equality, democracy, and fairness provide the standards to judge whether conditions are good or bad and whether policy solutions are preferable or detrimental. This book examines how partisan communicators recruit social and political values to persuade the public to support their positions on controversial issues. For example, someone who favors teaching alternatives to Darwin’s theory of evolution in public school science classes might argue that doing so upholds and promotes the value of freedom. This is sensible political strategy—after all, who is against freedom? The trouble is that opponents do the same thing, often targeting the same values. Value recruitment is thus one weapon in the arsenal that communicators and political entrepreneurs deploy to shape public opinion. This book explores the different strategies and tactics constituting value recruitment. It also examines how communicators respond to the value recruitment efforts of their opponents. Many examples of value recruitment from modern political debate are provided. It also describes in depth two cases in modern American politics that provide vivid examples of value recruitment by the competing sides. The book presents interviews with activists and policymakers in both cases to understand the values at stake and the value recruitment tactics in play. Because value recruitment targets political attitudes, the book also provides evidence from several experiments that examine how value recruitment shapes opinions. Greater recognition and understanding of value recruitment will deepen knowledge about the dynamics of political debate and public attitudes.
World War II and the Holocaust
Authors: Amar Tarik Cyril 
Published: October 2024

Abstract
This chapter discusses the breakthrough success of the television series Stakes Greater than Life in postwar Poland. It details the political and cultural background of 1960s Poland. Stawka’s enormous resonance cannot be understood without considering sensitive issues of national experience and identity. The series emerged in one of the countries most affected by World War II and at an important point in the development of its historical memory, when a young generation without personal memory of the war grew to adulthood, while, at the same time, television was rapidly increasing its hold on popular culture. The chapter explores Stawka’s place in Poland’s culture of memory, in particular with regard to questions of nationalism under Soviet hegemony. The chapter also probes Stawka’s omissions. Its most pronounced silence concerned the Holocaust. The chapter shows that this was a deliberate choice over an existing alternative.
Imagining a Perfect Soviet Russian Hero after Destalinization
Authors: Amar Tarik Cyril 
Published: October 2024

Abstract
Chapter 4 explores key themes in the Soviet television series Seventeen Moments of Spring, which addressed key issues of being Soviet and especially Russian, including the relationship to an outside world that was a defining Other. The series functioned as a parable rife with weighty lessons about truth and heroism, fascism and capitalism, the United States, crucial World War II ally and main Cold War adversary, and Germany, home to Nazism and the existential threat the latter had posed to the Soviet Union. Seventeen Moments also spoke to the traumatic memories of the cataclysmic war against Nazism and of Stalin, after the end of both his rule and the short destalinization of the Thaw period that followed it. The chapter addresses Soviet ideas of heroism, patriotism, bureaucracy and the enemy as a category. It explains how its hero Shtirlits (or Stierlitz) stood for an ideal Soviet citizen who was neither absolutely submissive nor a rebel.
Cold War between the Germanies
Authors: Amar Tarik Cyril 
Published: October 2024

Abstract
Chapter 5 addresses the context and making of the East German 1970s spy film franchise The Invisible Visor. It explains the East German idea of the noble agent, the Kundschafter, sketches Visor’s defining storyline, reconstructs the lopsided television rivalry between West and East Germany, and discusses Visor’s political significance and how the series was made. It details the close cooperation between its creators and East Germany’s intelligence service and secret police, the Stasi. The chapter discusses Visor’s presentation as fiction with a fundamental claim to political and historical truth that included allegations of contemporary Western subversion and crimes and references to Nazism. The chapter embeds The Invisible Visor in the history of the postwar competition between West and East Germany, in general and in the sphere of television in particular. Furthermore, it shows that, despite some similarities, the Bond movies were not a major influence on The Invisible Visor.
The Bible in the Catholic Life Cycle
Authors: Peppard Michael 
Published: October 2024

Abstract
This chapter and the next (chapter 4) build on the previous two, by extending the analysis of the Bible in Catholic worship into life-cycle events and other popular prayers and devotions. Some of these involve public worship, while others are private. This chapter surveys the biblical quotations, themes, and allusions that a typical Catholic encounters at life-cycle events of baptisms, confirmations, weddings, and funerals. Special attention is given to the role of the bride and groom in choosing biblical readings for their wedding and to the traditional prayers of Catholic funerals. In addition, biblical encounters are prescribed during confessions of sin and bouts with serious illness. Catholics have some of their deepest meditations on the Bible during peaks and valleys of the life cycle.
Origins of Catholic Biblical Art
Authors: Peppard Michael 
Published: October 2024

Abstract
Chapters 5, 6, and 7 show how the Bible is passed on through Catholic visuality, embodiment, storytelling, and poetry—in short, through a Catholic imagination. These chapters look first at the Bible in Catholic visual and dramatic arts (chapters 5 and 6) and then turn to the world of poetry, fiction, song, and screen (chapter 7). Chapter 5 describes the early “canon” of biblical art. It traces the origins of Catholic biblical art from the Roman Empire, where artisans’ choices for sarcophagi, catacombs, and eventually grand mosaics established an artistic biblical canon. That cluster of biblical episodes initially focused on the power of salvation by God and Jesus but, after the pivotal conversion of the emperor Constantine, gradually shifted toward the power of governance under God. Thus new biblical images rose to the fore, as David’s regal dynasty of old legitimated Christian rule.
Introduction to Infectious Diseases in Neurocognitive and Neuropsychiatric Medicine
Authors: Gale Shawn D. , Hedges Dawson W. , Erickson Lance D. 
Published: October 2024

Abstract
Neurocognitive and neuropsychiatric disorders contribute to a substantial amount of global morbidity. Unfortunately, available treatments for these diseases are often less than optimal. As such, identification of the causes of neurocognitive and neuropsychiatric disorders with goals of better understanding underlying pathophysiology and preventive strategies are paramount. The chapters in this book discuss the role of infectious diseases in neurocognitive and neuropsychiatric disorders including possible mechanisms as to how infectious diseases can affect the brain. An additional chapter explores how the microbiome is associated with brain function. As a whole, the chapters in this book provide insight into how infections including some common pathogens contribute to the burden of neurocognitive and neuropsychiatric diseases.
The Association Between Human Cytomegalovirus and Neurocognitive Disorders and Dementia
Authors: Eslick Guy D. 
Published: October 2024

Abstract
A member of the Herpesviridae family of viruses, human cytomegalovirus (HCMV) is a common infection, affecting up to 100 percent of the population in Africa and Asia, approximately 80 percent of people in Europe, and approximately 50 percent of the North American population. Further, it can produce a lifelong infection. Congenital cytomegalovirus is associated with hearing loss in newborns and may be a factor in adolescent cognitive function. In adults, findings from studies investigating associations between HCMV seropositivity and dementia have been inconsistent, with some findings suggesting an association with dementia, whereas other studies have not found an association. The high overall seroprevalence of HCMV infection likely makes it difficult to clearly identify associations between HCMV and neurocognitive disorders. Because of this, additional research with large sample sizes, prospective study designs, and attention to potentially confounding variables is needed to better characterize associations between HCMV and neurocognitive outcomes.