bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Technologies of Potash Fertiliser Production from Promising Raw Materials
Authors: Assylkhankyzy Aigerim , Seitmagzimova Galina 
Published: September 2024

Aims
To propose a new method for producing ballast-free potash fertilisers from promising raw materials.

Background
Potash ores from Chelkar and Zhilyan deposits with huge reserves were not previously explored. In this study, promising previously unexplored potash ore deposits with huge reserves were examined. Chemical and mineralogical compositions of potassium rock from Chelkar and Zhilyan deposits were determined based on which carnallite nature of both salts was found. However, Chelkar salt also contains a large amount of impurities of sodium chloride and calcium sulphate, and Zhilyan salt is more concentrated in potassium, contains less halite and does not contain insoluble gypsum. For these salts, a method of incomplete dissolution for raw material enrichment in potassium was selected and validated. The process of subsequent processing of the enriched salt was investigated by means of nitric acid decomposition of this salt and two-stage crystallisation of target salts from the extract. Thermodynamic probability of the reactions’ occurrence confirms the formation of an equilibrium solution. We calculated the activation energy for the main reaction,which proves the inside-kinetic region of behavior.

Objective
To study kinetics and chemical equilibrium of nitric acid decomposition of potassium raw materials.

Methods
Processing of previously unexplored potash ores, IR, XRD, SEM, and spectrometric methods of analysis.

Results
Chemical and mineralogical compositions of potash rock from Chelkar and Zhilyan deposits were determined, and the main stages of their processing have been studied.

Conclusion
New effective methods for producing chlorine-free potassium and potassium-nitrogen fertilisers have been proposed, which are characterized by minimal water input and the absence of production waste. As a result, a method for producing ballast-free potash fertilizer was proposed, which was not previously used for other kinds of raw materials. This method allows us to not only enrich raw materials with the potash component, but also to separate an insoluble gypsum intergrown with other potash minerals in the ore composition. The use of traditional processing methods does not allow for obtaining a completely water-soluble fertiliser.
Effect of Fluorine Addition on the Topographical Changes of the Dentine Tubular Walls and the Percentage of Fluorapatite in the PILP System
Authors: Napitupulu Elizhabet , Meidyawati Ratna , Putranto Aditya Wisnu 
Published: September 2024

Aims
This study aimed to determine the effect of fluorine in dentin remineralization. Guided tissue remineralization has been shown to remineralize affected dentin by forming intrafibrillar and extrafibrillar minerals. Through polymer-induced liquid precursor system, crystals are formed with small sizes and occur intrafibrillarly. The addition of fluorine can form larger fluoroapatite crystals and complete the remineralization to the extrafibrillar. Existing research only focuses on the dentine surface, while there has been no research to prove remineralization in the dentine tubular walls.

Objectives
The objective of this study was to determine the effect of adding 5ppm and 25ppm fluorine in the polymer-induced liquid precursor system on topographical changes and the percentage of fluoroapatite of the dentinal tubule walls.

Methods
Demineralized dentin blocks were immersed in 5ppm and 25ppm fluorine remineralization solution. Dentine blocks were cross-sectioned using fracture method and analyzed using field emission – scanning electron microscope, and x-ray diffraction.

Results
Topographical changes occurred on the dentinal tubule walls after remineralization with the addition of 5ppm and 25ppm fluorine through field emission– scanning electron microscope test. Statistical tests were performed using SPSS 25 (SPSS inc) software to analyze the X-ray diffraction data. X-ray diffraction analysis showed that there was no statistically significant difference between the addition of fluorine to the percentage of fluoroapatite mineral phase, but substantially there was an increase in the percentage of fluorapatite.

Conclusion
The addition of fluorine in the polymer-induced liquid precursor system does not influence changes in the topography of the dentinal tubule walls and the percentage of fluoroapatite.
Evaluation of Compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines for Conducting and Reporting Systematic Reviews in Three Major Periodontology Journals
Authors: Alharbi Fahad , Gufran Khalid , Alqerban Ali , Alqahtani Abdullah Saad , Asiri Saeed N , Almutairi Abdullah 
Published: September 2024

BackgroundData from the systematic review, with or without meta-analysis, form the basis of evidence-based medicine. Therefore, these studies should be conducted and reported according to the mandatory Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This study evaluated compliance with the PRISMA guidelines for conducting and reporting systematic reviews in three major periodontology journals.Material and MethodsA hand search was conducted in three major periodontal journals to identify Systematic Reviews (SRs) published between January 2018 and July 2022 using the words “Systematic Review” or “meta-analysis” in the title, abstract, or methodology of an article. The PRISMA statement checklist was used to evaluate eligible SRs, covering various sections of the review process. Descriptive statistics, univariate and multivariate analyses, and inter-examiner and intra-examiner reliability assessments were conducted for data analysis.ResultsA total of 87 SRs with meta-analyses were included in the current study. The proportion of published systematic reviews during the investigation period was 5.7% of the total published articles. 16 items were reported adequately in less than 75% of the included papers. Notably, items such as abstracts, data items, sensitivity analysis methods, synthesis results, reporting biases, evidence certainty, registration and protocol, data, code, and other materials availability were reported inadequately in some reviews.ConclusionThe findings from this study support previous research demonstrating that compliance with the PRISMA guidelines for the conduct and reporting of systematic reviews can vary, potentially attributing to a lack of understanding regarding these guidelines and their clinical significance.
Impact of a Neonatal Early-onset Sepsis Risk Calculator on Antibiotic Use in a Regional Australian Hospital
Authors: Zibell Kat , Du Plessis Louise , Peck Blake , Terry Daniel , Tickell David 
Published: September 2024

Aims
The aim of this study is to evaluate the safety and efficacy of the online neonatal EOS Calculator at an Australian regional hospital. In addition, the utility of commonly used biomarkers as screening tools for suspected Early Onset Sepsis (EOS) was also assessed.

Background
Early onset sepsis is a potentially fatal condition; however, it is also rare, and remains a diagnostic challenge. Despite evidence against the use of non-specific infection biomarkers in neonates, many neonatal facilities worldwide continue to use these to investigate and guide management of neonatal EOS. Nevertheless, there is little research regarding use of the neonatal EOS Calculator in Australian and non-tertiary facilities.

Objective
This study sought to evaluate the safety and efficacy of the online neonatal EOS Calculator at an Australian regional hospital.

Methods
Retrospective review of neonates born at ≥34+0 weeks gestation investigated and/or treated for presumed early onset sepsis across a two-year period within a 224-bed regional acute hospital in Victoria, Australia. Actual management was compared to neonatal EOS Calculator recommendations to determine the potential reduction in investigations and empiric intravenous antibiotic use. Outcome data and blood culture results were used to assess safety. Levels of commonly used biomarkers were compared to EOS calculation and clinical examination findings.

Results
Retrospective application of the EOS Calculator among 296 subjects with presumed EOS was shown to reduce investigation by 44.3% and empirical antibiotic use by 48.9%. No true cases of culture-positive sepsis were identified. Elevated initial C-reactive protein (CRP) correlated positively with high EOS Calculation results and clinical illness on examination; however, there was absent or negative correlation of EOS risk with other biomarkers.

Conclusion
Use of the neonatal EOS Calculator may substantially reduce rates of investigation and empirical antibiotic use at regional facilities. However, more data is needed to establish the safety of the calculator. Biomarkers are of low value in clinical decision making with well infants and may hinder decision making when compared to the EOS Calculator and clinical examination.
Controlling Obesity and Hypertension: Policies Oriented towards Behavior Change
Authors: Agustina Dewi , Wasiyem   , Bestari Eliza , Safari Fifi Ria Ningsih , Utami Tri Niswati , Aidha Zuhrina , Eliska   , Astuty Delfriana Ayu 
Published: September 2024

Background
Hypertension and obesity are emerging as significant non-communicable disease threats that can be addressed through behavioral changes.

Objective
This research aimed to develop policies to control hypertension and obesity among secondary school teachers.

Methods
A qualitative research approach using a descriptive study design was employed involving 21 research participants. Data were collected through interviews and observations, and height and weight measurements were taken to determine the body mass index. Five thematic areas were explored: 1) snack consumption, 2) sleep habits, 3) family health history, 4) exercise habits, and 5) health complaints in the last 6 months. Information obtained from participants was assessed for validity, guided by a logical, participant-centered theoretical framework. Thematic analysis was conducted for data analysis.

Results
This study has revealed a trend among the participants, i.e., 10 study participants were with systolic blood pressure exceeding 139 mmHg and diastolic blood pressure exceeding 90 mmHg. Fifteen participants were classified as obese, while 2 participants were categorized as overweight. Consumption of fried snacks emerged as the most common unhealthy dietary pattern among most of the participants. Unhealthy dietary patterns, such as consumption of fried snacks, and health problems, including hypertension, obesity, and musculoskeletal complaints, contribute to the risk of non-communicable diseases in the school teacher population.

Conclusion
Adopting preventive measures and a healthy lifestyle are essential to reduce health problems.
Experimental Investigation into the Anti-Inflammatory Properties of Curcumin for Orofacial Dental Pain Management
Authors: Tripathi Devika , Akram Ramiza , Kumar Raghvendra , Wal Pranay , Kumar Rai Awani , Rai Vinayak , Gupta Tanya 
Published: September 2024

Background:
The orofacial mucous membrane is an appealing route for drug delivery
to improve both systemic and local treatments. The aim of the present study was to develop
an oral dental film loaded with curcumin hydrotropic solid dispersion for sustained drug delivery
in the orofacial region. Compared to other dosage forms, films are the most elegant, palatable,
and suitable systems for systemic mucosal drug delivery.

Methods:
A hydrotropic solid dispersion technique utilizing 2 M sodium salicylate was developed
to enhance the solubility of curcumin, addressing its poor water solubility. By forming a
solid dispersion with a 1:4 ratio through solvent evaporation, the in-vitro physicochemical properties
of the curcumin-loaded system were evaluated.

Results:
The utilization of sodium salicylate hydrotrope in a molecular dispersion significantly
improved the solubility and bioavailability of curcumin. Subsequently, an oral dental film loaded
with hydrotropic solid dispersion was developed using the solvent casting method with
HPMC and gelatin as mucoadhesive polymers. Six different films were prepared using polymeric
blends with HPMC and gelatin, which showed homogeneity, yellowish colour, and high drug
content uniformity of 98.56 ± 3.24, with thickness ranging from 0.16 mm to 0.24 mm. The films
exhibited excellent folding endurance and tensile strength for improved patient palatability. Invitro
studies demonstrated a significant enhancement in curcumin release, reaching a maximum
of 94.66% over seven days in the presence of sodium salicylate hydrotrope, following firstorder
kinetics. An ex vivo permeation of Cur-F3 film had a significant effect on mucoadhesion.

Conclusion:
Using hydrotropes in oral film formulation is a new and sustainable method for
delivering clinically significant curcumin through the oral mucosa. As a result, it is recommended
for use in the design of treatments for other dental diseases.

conclusion:
The utilization of hydrotropes for oral film formulation presents a robust and sustainable technique for the oral mucosal delivery of curcumin, a compound with significant clinical implications. This could potentially revolutionize the field of dental therapeutics, offering a more efficient and patient-friendly method of drug delivery.
Exploring the Feasibility of Digital Voice Assistants for Delivery of a Home-Based Exercise Intervention in Older Adults With Obesity and Type 2 Diabetes Mellitus: Randomized Controlled Trial
Authors: Glavas Costas , Scott David , Sood Surbhi , George Elena S , Daly Robin M , Gvozdenko Eugene , de Courten Barbora , Jansons Paul 
Published: September 2024

Background
Current clinical guidelines for the management of type 2 diabetes mellitus (T2DM) in older adults recommend the use of antihyperglycemic medications, monitoring of blood glucose levels, regular exercise, and a healthy diet to improve glycemic control and reduce associated comorbidities. However, adherence to traditional exercise programs is poor (<35%). Common barriers to adherence include fear of hypoglycemia and the need for blood glucose level monitoring before exercise. Digital health strategies offer great promise for managing T2DM as they facilitate patient-practitioner communication, support self-management, and improve access to health care services for underserved populations. We have developed a novel web-based software program allowing practitioners to create tailored interventions and deliver them to patients via digital voice assistants (DVAs) in their own homes.

Objective
We aim to evaluate the feasibility of a 12-week, home-based, personalized lifestyle intervention delivered and monitored by DVAs for older adults with obesity and T2DM.

Methods
In total, 50 older adults with obesity aged 50-75 years with oral hypoglycemic agent–treated T2DM were randomized to the intervention (DVA, n=25) or a control group (n=25). Participants allocated to the DVA group were prescribed a home-based muscle strengthening exercise program (~20- to 30-min sessions) and healthy eating intervention, delivered via DVAs (Alexa Echo Show 8; Amazon) using newly developed software (“Buddy Link”; Great Australian Pty Ltd). Control group participants received generalized physical activity information via email. Outcomes were feasibility, DVA usability (System Usability Scale), and objectively assessed physical activity and sedentary time (wrist-worn accelerometers).

Results
In total, 45 (90%) out of 50 participants completed this study. Mean adherence to prescribed exercise was 85% (SD 43%) with no intervention-related adverse events. System usability was rated above average (70.4, SD 16.9 out of 100). Compared with controls, the DVA group significantly decreased sedentary time (mean difference –67, SD 23; 95% CI –113 to –21 min/d), which was represented by a medium to large effect size (d=–0.6).

Conclusions
A home-based lifestyle intervention delivered and monitored by health professionals using DVAs was feasible for reducing sedentary behavior and increasing moderate-intensity activity in older adults with obesity and T2DM.

Trial Registration
Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12621000307808; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381364&isReview=true
Advancing AI Data Ethics in Nursing: Future Directions for Nursing Practice, Research, and Education
Authors: Ball Dunlap Patricia A , Michalowski Martin 
Published: September 2024

Abstract
The ethics of artificial intelligence (AI) are increasingly recognized due to concerns such as algorithmic bias, opacity, trust issues, data security, and fairness. Specifically, machine learning algorithms, central to AI technologies, are essential in striving for ethically sound systems that mimic human intelligence. These technologies rely heavily on data, which often remain obscured within complex systems and must be prioritized for ethical collection, processing, and usage. The significance of data ethics in achieving responsible AI was first highlighted in the broader context of health care and subsequently in nursing. This viewpoint explores the principles of data ethics, drawing on relevant frameworks and strategies identified through a formal literature review. These principles apply to real-world and synthetic data in AI and machine-learning contexts. Additionally, the data-centric AI paradigm is briefly examined, emphasizing its focus on data quality and the ethical development of AI solutions that integrate human-centered domain expertise. The ethical considerations specific to nursing are addressed, including 4 recommendations for future directions in nursing practice, research, and education and 2 hypothetical nurse-focused ethical case studies. The primary objectives are to position nurses to actively participate in AI and data ethics, thereby contributing to creating high-quality and relevant data for machine learning applications.
Transient elastography, ultrasound imaging and liver enzymes in diagnosis of cystic fibrosis-related liver disease in children
Authors: Tsyunchyk Yu.G. , Shevchenko I.M. , Tsyunchyk A.V. , Stepanov G.F. 
Published: September 2024

Background. Liver disease is responsible for relevant morbidity and mortality in children with cystic fibrosis. We aimed to assess the predictive value of a combination of transient elastography, ultrasound imaging and serum liver enzymes for diagnosis of cystic fibrosis-related liver disease. Materials and methods. A total of 108 children aged 0–17 years with cystic fibrosis were examined. The fibrosis stage was determined using transient elastography. The activity of enzymes (alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase-5), ultrasound parameters of the liver at different stages of liver fibrosis have been investigated. Results. Liver fibrosis of varying severity (F1-F4) was detected in 29.6 % of patients with cystic fibrosis. Liver cirrhosis was observed in 14.8 % of children with cystic fibrosis. The association between an elevated activity of alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase-5, an enlargement of the left lobe of the liver and the degree of fibrosis F1-F4 was found. Moreover, a significant increase in the size of the left lobe corresponded to a higher degree of fibrosis. A reverse correlation was detected between the k coefficient (the ratio of the sizes of the right and left lobes of the liver) and the degree of fibrosis, with a greater degree of fibrosis corresponding to a lower value of this parameter. The maximum enlargement of the left lobe of the liver, the lowest value of the k coefficient, and the dilation of the portal and splenic veins were observed in patients with liver cirrhosis. Conclusions. The transient elastography, changing of ultrasound liver parameters with elevated activity of the alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase-5 could be used for early diagnosis of cystic fibrosis-related liver disease.
Analytical Method Development: A Review
Authors: Bandawane Akash , Saudagar Ravindranath 
Published: September 2024

The oldest form of medicine known to mankind is herbal medicine. Today, it is the most widely practiced form of medicine in the world. Using medicinal plants for treatment is considered very safe as there is no or minimal side effects. Most of the plant materials collected from the rain forests and other places are currently used for conducting extensive research for their potential medicinal value. In Ayush systems of medicine about 8,000 herbal drugs have been codified 2. One of them is Coriandrum sativum Linn. belongs to the family Apiaceae and commonly known as kishneez khushk in Unani medicine.3It possesses multiple pharmacological activities which are revealed previously, such as anxiolytic, antidepressant, sedative-hypnotic, neuroprotective, antibacterial, antifungal, anthelmintic, insecticidal, antioxidant, cardiovascular, analgesic, anticonvulsant, memory enhancing, antidiabetic, anticancer, gastrointestinal, deodorizing, dermatological, hypolipidemic, anti-inflammatory, diuretic, reproductive, hepatoprotective,, antimutagenic, detoxification etc4,14. The current review gives an overview of the pharmacological effects and chemical constituents of Coriandrum sativum.
Keywords: Coraindrum sativum Linn. herbal medicine, pharmacological activities.
Microwave Assisted Technology and its Role in Pharma Industry
Authors: Darekar Avinash , Shahane Akshata , Saudagar Ravindra 
Published: September 2024

Energy is the basic source required for carrying out work. Current paper describes a brief review of microwave technique, its use in pharmaceutical sciences. Microwave technique are being a traditional method for drying, synthesizing, preparing, heating, etc . They are also used during organic synthesis. Microwave can be used as cross heating barriers which arrive due to preliminary, insufficient heating of the product resulting in an inappropriate product. The microwave energy ranges from 300MHz to 300GHz which is sufficient enough for heating and drying of pharmaceuticals. Microwave techniques benefits one with time management, high percentage of yield, faster process, clear chemistry.
Keywords: Microwave, drying, heating, application in pharmaceutical sciences
Coriandrum sativum Linn. Traditional, Biochemical and Biological activities: An Overview
Authors: Fatima Gulnar , Siddiqui Aisha , Jamal Anwar , Chaudhary S. 
Published: September 2024

The oldest form of medicine known to mankind is herbal medicine. Today, it is the most widely practiced form of medicine in the world. Using medicinal plants for treatment is considered very safe as there is no or minimal side effects. Most of the plant materials collected from the rain forests and other places are currently used for conducting extensive research for their potential medicinal value. In Ayush systems of medicine about 8,000 herbal drugs have been codified 2. One of them is Coriandrum sativum Linn. belongs to the family Apiaceae and commonly known as kishneez khushk in Unani medicine.3It possesses multiple pharmacological activities which are revealed previously, such as anxiolytic, antidepressant, sedative-hypnotic, neuroprotective, antibacterial, antifungal, anthelmintic, insecticidal, antioxidant, cardiovascular, analgesic, anticonvulsant, memory enhancing, antidiabetic, anticancer, gastrointestinal, deodorizing, dermatological, hypolipidemic, anti-inflammatory, diuretic, reproductive, hepatoprotective,, antimutagenic, detoxification etc4,14. The current review gives an overview of the pharmacological effects and chemical constituents of Coriandrum sativum.