bluuebunny/crossref_metadata_2025_split huggingface dataset:
Care Pathways in Persistent Orofacial Pain
Authors: Breckons M. , Bissett S.M. , Exley C. , Araujo-Soares V. , Durham J. 
Published: November 2016

Persistent orofacial pain is relatively common and known to have an adverse effect on quality of life. Previous studies suggest that the current care pathway may be problematic, but it is not well understood which health services patients access and what their experience is. The aim of this study was to explore care pathways and their impact from the perspective of patients. Qualitative interviews were conducted with a maximum variation sample of patients recruited from primary (community based) and secondary (specialist hospital based) care in the United Kingdom. Questions focused on the stages in their pathway and the impact of the care that they had received. Interviews were digitally recorded and transcribed verbatim, and analysis followed principles of the constant comparative method. NVivo 10 was used to help organize and analyze data. Twenty-two patients were interviewed at baseline, and 18 took part in a second interview at 12 mo. Three main themes emerged from the data: the “fluidity of the care pathway,” in which patients described moving among health care providers in attempts to have their pain diagnosed and managed, occurring alongside a “failure to progress,” where despite multiple appointments, patients described frustration at delays in obtaining a diagnosis and effective treatment for their pain. Throughout their care pathways, patients described the “effects of unmanaged pain,” where the longer the pain went unmanaged, the greater its potential to negatively affect their lives. Findings of this study suggest that the current care pathway is inefficient and fails to meet patient needs. Future work needs to focus on working with stakeholder groups to redesign patient-centered care pathways. Knowledge Transfer Statement: Data from qualitative interviews conducted with patients with persistent orofacial pain suggest significant problems with the existing care pathway, consisting of delays to diagnosis, treatment, and referral. Patients describing their struggle to progress through the current care pathway highlighted the difficulties occurring while living with orofacial pain. This study suggests a need for a revised care pathway, which better meets the needs of people with persistent orofacial pain.
Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice
Authors: Canali Susanna , Zumbrennen-Bullough Kimberly B. , Core Amanda B. , Wang Chia-Yu , Nairz Manfred , Bouley Richard , Swirski Filip K. , Babitt Jodie L. 
Published: November 2016

Key Points
Endothelial Bmp6 conditional knockout mice exhibit hemochromatosis, whereas hepatocyte and macrophage Bmp6 conditional knockout mice do not. Our data support a model in which EC Bmp6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin production.
Impact of long-term medical conditions on the outcomes of psychological therapy for depression and anxiety
Authors: Delgadillo Jaime , Dawson Alexander , Gilbody Simon , Böhnke Jan R. 
Published: November 2016

BackgroundLong-term conditions often coexist with depression and anxiety.AimsTo assess the effectiveness of stepped-care psychological therapies for patients with long-term conditions.MethodData from 28 498 patients were analysed using regression to model depression (Patient Health Questionnaire (PHQ-9)) and anxiety (Generalised Anxiety Disorder scale (GAD-7)) outcomes. Post-treatment symptoms and effect sizes (d) were estimated for individuals with and without long-term conditions, controlling for covariates. The likelihood of access and response to intensive psychological interventions was also examined.ResultsHigher post-treatment symptoms were predicted for patients with musculoskeletal problems (d = 0.22–0.27), chronic obstructive pulmonary disease (d = 0.26–0.33), diabetes (d = 0.05–0.13) and psychotic disorders (d = 0.50–0.58). Most long-term conditions were associated with greater odds of accessing high-intensity therapies, yet individuals who accessed these continued to have higher average post-treatment symptoms.ConclusionsSome long-term conditions are associated with greater intensity of care and poorer outcomes after therapy.
Epitope-Specific Antitumor Immunity Suppresses Tumor Spread in Papillary Thyroid Cancer
Authors: Ehlers Margret , Kuebart Anne , Hautzel Hubertus , Enczmann Juergen , Reis Anna-Carinna , Haase Matthias , Allelein Stephanie , Dringenberg Till , Schmid Christine , Schott Matthias 
Published: November 2016

AbstractContext:Papillary thyroid cancer (PTC) is characterized by a lymphocytic infiltration. PTC patients with lymphocytic infiltration may have a better clinical outcome.Objective:Characterization of tumor epitope-specific immunity and correlation analyses with the clinical outcome.Patients:150 PTC patients; 40 Hashimoto thyroiditis (HT) patients; 21 healthy controls; 27,239 healthy whites (for HLA typing).Main Outcome Measures:HLA class I restricted thyroperoxidase (TPO) and thyroglobulin (Tg) epitope-specific T cells (tetramer analyses), correlation analyses between HLA class II phenotypes, T cell immunity, and the clinical course.Results:The frequency of TPO- and Tg-specific CD8+ T cells in PTC patients was largely increased compared with healthy controls (TPO and Tg, P &lt; 0.005 and P &lt; 0.005) and was similar to those in HT patients. HLA-DQB1*03–positive PTC patients had a significantly lower risk [risk ratio (RR), 0.170; 95% confidence interval (CI), 0.037 to 0.755; P &lt; 0.05] and HLA-DRB1*03–positive and HLA-DQB1*02–positive PTC patients a significantly higher risk (HLA-DRB1*03: RR, 4.400; 95% CI, 1.378 to 14.05; P &lt; 0.05; HLA-DQB1*02: RR, 3.692; 95% CI, 1.102 to 12.38; P &lt; 0.05) for distant metastases, compared with patients with other haplotypes. HLA-DQB1*03–positive PTC patients revealed an increased responsiveness of tumor epitopes in vitro. These tumor epitope-specific CD8+ T cells were also found in lymph node metastases of HLA-DQB1*03–positive PTC patients.Conclusion:We demonstrate a tumor epitope-specific immunity in PTC patients and the protective role of HLA-DQB1*03 against metastatic spread. These results have direct implications for new treatment options with immune checkpoint inhibitors.
Analysis of Physiological Respiratory Variable Alarm Alerts Among Laboring Women Receiving Remifentanil
Authors: Weiniger Carolyn F. , Carvalho Brendan , Stocki Daniel , Einav Sharon 
Published: November 2016

BACKGROUND:
Remifentanil may be used by laboring women for analgesia, despite controversy because of potential apneas. We evaluated candidate variables as early warning alerts for apnea, based on prevalence, positive predictive rate, sensitivity for apnea event detection, and early warning alert time intervals (lead time) for apnea.

METHODS:
We performed a secondary analysis of respiratory physiological data that had been collected during a prospective IRB-approved study of laboring women receiving IV patient-controlled boluses of remifentanil 20 to 60 μg every 1 to 2 minutes. Analyzed data included the respiratory rate (RR), end-tidal CO2 (Etco
2), pulse oximetry (Spo
2), heart rate (HR), and the Integrated Pulmonary Index (IPI; Capnostream 20; Medtronic, Boulder, CO) that had been recorded continuously throughout labor. We defined immediate early warning alerts as any drop in a variable value below a prespecified threshold for 15 seconds: RR < 8 breaths per minute (bpm), Etco
2 < 15 mm Hg, and Spo
2 < 92%. We defined alerts as “sustained” when the value remained below the threshold for ≥ 10 further seconds. The IPI value (1 to 10; 10 = healthy patient, ≤4 = immediate attention required, 1 = dire condition) was generated from a proprietary algorithm using RR, Etco
2, Spo
2, and HR parameters. Apnea was defined as maximal CO2 < 5 mm Hg for at least 30 consecutive seconds.

RESULTS:
We counted 62 apneas, among 10 of 19 (52.6%) women who received remifentanil (total dose 1725 ± 1392 μg, administered over 160 ± 132 minutes). We counted 331 immediate early warning alerts for the variables; 271 (82%) alerts were sustained for ≥10 seconds. The positive predictive value of alerts for apnea was 35.8% (99% confidence interval [CI]: 27.1–45.6), 28.9% (99% CI: 20.8–38.7), 4.3% (99% CI: 1.9–9.6), and 24.6% (99% CI: 18.3–32.2) for RR, Etco
2, Spo
2, and IPI, respectively. The sensitivity for apnea event detection was 100% (99% CI: 90.3–100) for RR (<8 bpm) and IPI (≤4); 75.8% (99% CI: 59.8–86.9) for Etco
2 <15 mm Hg; and 14.5% (99% CI: 6.5–29.4) for Spo
2 <92%. We found a statistically significant difference in the timing of RR, Etco
2, Spo
2, and IPI alerts for apnea; Friedman’s Q = 33.53; P < .0001. The Etco
2 had a median (interquartile range) lead time of −0.2 (−12.2 to 0.7) seconds, and Spo
2 had a median (interquartile range) lead time of 40.0 (40.0 to 40.0) seconds.

CONCLUSIONS:
The majority of women receiving IV remifentanil for labor analgesia experienced apneas. Alerts for Etco
2 (<15 mm Hg), RR (<8 bpm), and IPI (≤4) detected most apneas, whereas Spo
2 alerts missed the majority of apneas. All variables had a low positive predictive rate, demonstrating the limitations of the respiratory monitors utilized as early warning surveillance for apneas in this setting.
Whole genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic trait mapping
Authors: Dreger Dayna L. , Rimbault Maud , Davis Brian W. , Bhatnagar Adrienne , Parker Heidi G. , Ostrander Elaine A. 
Published: November 2016

In the decade following publication of the draft genome sequence of the domestic dog, extraordinary advances with application to several fields have been credited to the canine genetic system. Taking advantage of closed breeding populations and the subsequent selection for aesthetic and behavioral characteristics, researchers have leveraged the dog as an effective natural model for the study of complex traits, such as disease susceptibility, behavior, and morphology, generating unique contributions to human health and biology. When designing genetic studies using purebred dogs, it is essential to consider the unique demography of each population, including estimation of effective population size and timing of population bottlenecks. The analytical design approach for genome-wide association studies (GWAS) and analysis of whole genome sequence (WGS) experiments are inextricable from demographic data.We have performed a comprehensive study of genomic homozygosity, using high-depth WGS data for 90 individuals, and Illumina HD SNP data from 800 individuals representing 80 breeds. These data were coupled with extensive pedigree data analyses for 11 breeds that, together, allowed us to compute breed structure, demography, and molecular measures of genome diversity. Our comparative analyses characterize the extent, formation, and implication of breed-specific diversity as it relates to population structure. These data demonstrate the relationship between breed-specific genome dynamics and population architecture, and provide essential important considerations influencing the technological and sampling cohort design of association and other genomic studies.
Care Certificate Standards 5 and 6: working in a person-centred way; and communication
Authors: Peate Ian 
Published: November 2016

These two standards of the Care Certificate are central to the provision of high-quality, safe and effective care. This article discusses the role of the healthcare assistant and assistant practitioner (HCA and AP) when working in a person-centred way. Putting people at the centre of all that is done can demonstrate that the HCA and AP are working in a person-centred way where the person being cared for is being provided with support. Communicating effectively allows care and support to be person-centred. Communication is a crucial aspect of a caring relationship and helps to promote trust in relationships with other workers and families as well as those people being cared for. Failing to communicate effectively can jeopardise the care and support the HCA and AP provide. Person-centred care and effective communication are the hallmarks of high-quality, safe and effective care. This article discusses the importance of communicating effectively in order to provide person-centred care.
Evaluation of the leadership characteristics of secondary school principals from the teachers’ perspective<p> Ortaöğretim okullarında görev yapan müdürlerin liderlik davranış özelliklernin öğretmen algılarına göre değerlendirilmesi
Authors: Öksüzoğlu Meryem 
Published: November 2016

Leadership is one of the most extensively discussed topics. Wherever there is management, the manager’s leadership characteristics and behavior related with these have great importance. At schools, it is more crucial to be able to effective than to be able to use authority. In these sense, a principal needs to unite teachers towards a goal and in order to achieve that, should have the necessary leadership characteristics. This article, aims to investigate teachers’ perspective of principals’ leadership characteristics and behavior. The samle derived from the capital city, Nicosia of North Cyprus. In order to determine the principals’ leadership characteristics and behavior both survey and interview methods were applied. Through data, the particular leadership characteristics and behavior have been examined. Findings suggest that, school principals’ leadership characteristics and behavior varies. The most common leadership characteristics and behaviors were coming up with new projects, openly stating requests, and giving importance to following procedurs. The behavior and leadership characteristics that came out the least common were risk taking, being able to positively handle criticism, and being flexible and openness to change. ÖzetLiderlik günümüzde en çok tartışılan konuların başında gelmektdedir. Yönetimin olduğu yerde yöneticinin sahip olduğu ve ortaya koyacağı liderlik davranış özellikleri büyük önem taşımaktadır. Okulda yönetim, yetki kullanmaktan çok, etkili olmayı gerektirmektedir. Liderlikte ise etkileme vardır. Bu bakımdan okul yöneticilerinin, okulu amaçlanan noktaya götürebilmeleri için öğretmenlerde amaç birlikteliği oluşturabilmek için liderlik özellikleri taşıması gerekmektedir. Bu araştırma, Kuzey Kıbrıs’ta Lefkoşa merkezde bulunan ortaöğretim okullarında görev yapan müdürlerin, liderlik davranış özelliklerinin, öğretmen algılarına göre belirlemeyi amaçlamaktadır. Okul müdürlerinin liderlik davranış özelliklerini belirleyebilmek amacıyla ölçme aracı olarak anket ve mülakat yöntemi kullanılmıştır. Elde edilen veriler ışığında hangi liderlik davranışlarını gösterdiklerini belirlemek hedeflenmiştir. Bulgular okul müdürlerinin liderlik davranış özelliklerinin farklılık gösterdiğini ortaya koymuştur. Müdürlerin en fazla ortaya koyduğu davranışlar arasında yeni proje üretme, açık şekilde talimat verme, kural ve prensiplere uymayı önemseme yer almaktadır. En düşük olarak öne çıkan liderlik davranışları ise risk alma, eleştirilere açık olma, esnek ve değişime açıklık özellikleridir.
The stability of laughter
Authors: Nikopoulos James 
Published: November 2016

AbstractThis article synthesizes a broad body of research in order to propose a concise overview of how laughter functions as a heuristic for social situations and cultural artifacts. It argues that all laughter is indelibly associated with positivity. Phenomena traditionally interpreted as contradicting this claim – such as malicious laughter and pathological laughter – only serve to reinforce an understanding we are born with which connects laughter to positivity. I argue that laughter is perceived as positive or otherwise because context either reinforces an innate understanding that links laughter to positivity, or else forces that understanding into some degree of contradiction. Either way, the link is never dissolved. Basing its claims on evolutionary theory and emotion research, and informed by the two-thousand-plus-year history of the philosophy of humor, this study is the first to systematically discuss those aspects of laughter that transcend context and subject.
Query-Specific Distance and Hybrid Tracking Model for Video Object Retrieval
Authors: Ghuge C.A. , Ruikar Sachin D. , Prakash V. Chandra 
Published: November 2016

AbstractIn the area of modern intelligent systems, the retrieval process of video objects is still a challenging task because objects are usually affected by object confusion, similar appearance among objects, different posing, small size of objects, and interactions among multiple objects. In order to overcome these challenges, the video object is retrieved based on the trajectory points of the multiple-motion objects. However, if an object is in an occlusion situation, the calculation of trajectory points from the objects is considerably altered. In order to overcome the above challenges, we have proposed a technique of query-specific distance and hybrid tracking model for video object retrieval. To verify the performance of the proposed method, five videos were collected from the CAVIAR dataset. Then, the proposed tracking process was applied with these five videos and the performance was analysed based on various parameters, such as precision, recall, and f-measure. From the results, we can prove that the proposed hybrid model attained a higher f-measure of 76.7% compared to that of other existing tracking models, such as the nearest neighbourhood algorithmic model and spatial-exponential weighted moving average model.
Application of the order statistics to the fault tolerant systems / Zastosowanie statystyk porządkowych do systemów tolerujących uszkodzenia
Authors: Andrzejczak Karol 
Published: November 2016

Abstract
Various models of ordered random variables having different interpretations have been introduced and studied extensively in the literature. The most popular of these are order statistics obtained by arranging n random variables (rv’s) in non-decreasing order of magnitude. Order statistics appear in many areas of statistical theory and applications including quality control, robustness, outlier detection, and reliability analysis. In this paper we study the construction of the functional and numerical reliability characteristics for the fault tolerant systems with so called “k-out-of-n” threshold reliability structure based on order statistics.
Analysys of reliability and cost of repairs of trucks under long-term lease conditions / Analiza niezawodności i kosztów napraw samochodów ciężarowych w warunkach wynajmu długoterminowego
Authors: Dmowski Artur , Ignaciuk Piotr , Ślęzak Marcin , Niewczas Andrzej 
Published: November 2016

Abstract
The article presents the results of the reliability tests of three makes of trucks. They used samples of 30 vehicles of each make. The vehicles were used by transport companies on a rental basis. The analysis omitted defects of the body-work of the vehicles as the component unrelated to a particular make. The first part of the analysis characterized operating process in respect to mileages and operating time. Then the analysis of the reliability of vehicles and their components was conducted taking into account the mileages till the first recorded defect and separately inter-repair periods’ mileages. The analyses presented are part of a larger work, which aims to develop a method for evaluating the operational quality of trucks from the point of view of the owner of the rental vehicles.
Fuzzy ideals of ordered semigroups with fuzzy orderings
Authors: Huang Xiaokun , Li Qingguo 
Published: November 2016

AbstractThe purpose of this paper is to introduce the notions of ∈, ∈ ∨qk-fuzzy ideals of a fuzzy ordered semigroup with the ordering being a fuzzy relation. Several characterizations of ∈, ∈ ∨qk-fuzzy left (resp. right) ideals and ∈, ∈ ∨qk-fuzzy interior ideals are derived. The lattice structures of all ∈, ∈ ∨qk-fuzzy (interior) ideals on such fuzzy ordered semigroup are studied and some methods are given to construct an ∈, ∈ ∨qk-fuzzy (interior) ideals from an arbitrary fuzzy subset. Finally, the characterizations of generalized semisimple fuzzy ordered semigroups in terms of ∈, ∈ ∨qk-fuzzy ideals (resp. ∈, ∈ ∨qk-fuzzy interior ideals) are developed.
Fixed point theorems for cyclic contractive mappings via altering distance functions in metric-like spaces
Authors: Chen Jianhua , Huang Xianjiu , Li Shengjun 
Published: November 2016

Abstract
In this paper, we introduce two different contractive conditions and prove some new fixed point theorems for cyclic (ψ,ϕ,φ)
α
-contractive mappings and α-(κ,φ)g
-contractive mappings in complete metric-like spaces via altering distance functions. Our results generalize and extend some existing results. Moreover, some examples are given to support the obtained results.
Sorption properties of Amberlite XAD 7 functionalized with sodium β-glycerophosphate
Authors: Gabor Andreea , Davidescu Corneliu Mircea , Negrea Adina , Ciopec Mihaela , Muntean Cornelia , Duteanu Narcis , Negrea Petru 
Published: November 2016

Abstract
This paper presents the sorption properties of a new adsorbent material prepared by impregnating Amberlite XAD 7 polymer with sodium β-glycerophosphate. For impregnation, the pellicular vacuum solvent vaporization method was employed. The functionalization was evidenced by energy dispersive X-ray analysis. The usefulness of this material and its performances were studied for the adsorption of the rare earth element La(III) in batch experiments. The influence of various parameters affecting the adsorption of lanthanum like contact time, initial concentration, pH value, and temperature was studied. The kinetic of the adsorption process was best described by the pseudo-second-order model. Sips isotherm was found to be the best fit of the equilibrium data. The maximum adsorption capacity of the functionalized material was of 33.8 mg La(III)/g. The values of thermodynamic parameters (ΔG
o, ΔH
o, ΔS
o) showed that the adsorption process was endothermic and spontaneous. The results proved that Amberlite XAD 7 functionalized with sodium β-glycerophosphate is an efficient adsorbent for the removal of La(III) ions from aqueous solutions. Quantum chemistry was performed using Spartan software.
Synthesis, characterization and enzymatic degradation of copolymers of ε-caprolactone and hydroxy-fatty acids
Authors: Aparaschivei Diana , Todea Anamaria , Păuşescu Iulia , Badea Valentin , Medeleanu Mihai , Şişu Eugen , Puiu Maria , Chiriţă-Emandi Adela , Peter Francisc 
Published: November 2016

Abstract
New copolymers of ε-caprolactone with three hydroxy-fatty acids, 12-hydroxy stearic acid, 16-hydroxyhexadecanoic acid and ricinoleic acid, were synthesized by catalytic polyesterification. The reactions were carried out in solvent-free systems and in organic solvents as well, using tin(II) 2-ethylhexanoate as catalyst, at different temperatures and molar ratios of the comonomers. Cyclic and linear polymeric products with medium molar weight of about 2000 Da have been synthesized and their chemical structures were confirmed by FT-IR, NMR and MALDI-TOF MS analysis. The synthesis parameters were optimized and the ε-caprolactone/hydroxy acid molar ratio was set as 5:1, according to mass spectrometry results. The biodegradability of the newly synthesized polymers was studied in the presence of Candida antarctica B lipase in phosphate buffer solutions (pH=7.4), at 37°C. The weight-loss profile emphasized the degradation of the 16-hydroxyhexadecanoic acid based polymer samples at more than 50% of their initial weight in 18 days of incubation in the presence of the lipase. The composition of the degradation products was assessed using the GC-MS technique and displayed residues of the comonomers moieties.