bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Human Advantage
Authors: Herculano-Houzel Suzana 
Published: September 2016

Why our human brains are awesome, and how we left our cousins, the great apes, behind: a tale of neurons and calories, and cooking.
Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25% of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals, but not because we are evolutionary outliers. The human brain was not singled out to become amazing in its own exclusive way, and it never stopped being a primate brain. If we are not an exception to the rules of evolution, then what is the source of the human advantage?
Herculano-Houzel shows that it is not the size of our brain that matters but the fact that we have more neurons in the cerebral cortex than any other animal, thanks to our ancestors' invention, some 1.5 million years ago, of a more efficient way to obtain calories: cooking. Because we are primates, ingesting more calories in less time made possible the rapid acquisition of a huge number of neurons in the still fairly small cerebral cortex—the part of the brain responsible for finding patterns, reasoning, developing technology, and passing it on through culture.
Herculano-Houzel shows us how she came to these conclusions—making “brain soup” to determine the number of neurons in the brain, for example, and bringing animal brains in a suitcase through customs. The Human Advantage is an engaging and original look at how we became remarkable without ever being special.
Social Multimedia Networks Behaviour Model & Architecture
Authors: Gunawardhana L. K. Pulasthi Dhananjaya , Palaniappan Sellappan 
Published: September 2016

AbstractPeople constantly use social multimedia networks to communicate with one another, with users mostly sharing data, such as photos and videos. We examine the motivations that drive colluders to form alliances over social networking platforms and determine how these groups create coalitions to advance their interests. We also investigate the network architectures that underlie social multimedia networks and how these platforms circulate. Such architectures are connected to different protocols, including WebID, Semantic Pingback and PubSubHubbub, to form a logical semantic circulating social multimedia network that delivers a centralised social network structure.
Interphase Optimum via Synergistic Effect of Poly(1,3‐dioxolane) Electrolytes and Lithium Difluorophosphate for Stable Lithium Metal Batteries
Authors: Hu Anyi , Liao Zhu , Yang Qirui , Huang Jun , Wei Zhuangzhuang , Sun Yukun , Zhao Enyou , Zhang Zhengxi , Yang Li , Saito Nagahiro , Orita Akihiro 
Published: September 2024

AbstractSolid polymer electrolytes (SPEs) hold great promise for future applications of high‐energy lithium metal batteries (LMBs). Unfortunately, inadequate room‐temperature ionic conductivity, sluggish interfacial charge transport, and uncontrolled electrode/electrolyte interface reactions severely limit their widespread applications. Herein, poly(1,3‐dioxolane) electrolytes (PDEs) are prepared in situ by introducing lithium difluorophosphate (LiDFP, LiPO2F2) as a multifunctional additive, which not only achieves excellent ionic conductivity but facilitates interfacial charge transport. Meanwhile, a high‐mechanical‐stability organic–inorganic hybrid solid electrolyte interphase (SEI) is formed by the synergistic effect of PDEs and LiDFP. The enrichment of LiF and LixPOyFz species in SEI formed by the preferential reduction of LiDFP ensures outstanding mechanical stability, and the ring‐opening polymerization of 1,3‐dioxolane provides the SEI excellent adaptability to the repetitive volume changes of lithium metal anode, which mitigates crack and regeneration of SEI and reduces side reactions between active Li and electrolytes. Therefore, based on PDEs, the symmetric Li cell enables steady cycling for 2000 h. The Li‐LiFePO4 cell achieves superior long‐term cycling stability (over 1200 cycles) and wide operating temperature (−20 ∼ 60 °C). Also, the Li‐LiNi0.6Mn0.2Co0.2O2 exhibits favorable cycling stability. This study provides solutions to ongoing pain point issues of SPEs and facilitates practical applications of SPEs in high‐energy LMBs.
Viscoelasticity of Hyaluronic Acid Hydrogels Regulates Human Pluripotent Stem Cell‐derived Spinal Cord Organoid Patterning and Vascularization
Authors: Chen Xingchi , Liu Chang , McDaniel Garrett , Zeng Olivia , Ali Jamel , Zhou Yi , Wang Xueju , Driscoll Tristan , Zeng Changchun , Li Yan 
Published: September 2024

AbstractRecently, it has been recognized that natural extracellular matrix (ECM) and tissues are viscoelastic, while only elastic properties have been investigated in the past. How the viscoelastic matrix regulates stem cell patterning is critical for cell‐ECM mechano‐transduction. Here, this study fabricated different methacrylated hyaluronic acid (HA) hydrogels using covalent cross–linking, consisting of two gels with similar elasticity (stiffness) but different viscoelasticity, and two gels with similar viscoelasticity but different elasticity (stiffness). Meanwhile, a second set of dual network hydrogels are fabricated containing both covalent and coordinated cross–links. Human spinal cord organoid (hSCO) patterning in HA hydrogels and co‐culture with isogenic human blood vessel organoids (hBVOs) are investigated. The viscoelastic hydrogels promote regional hSCO patterning compared to the elastic hydrogels. More viscoelastic hydrogels can promote dorsal marker expression, while softer hydrogels result in higher interneuron marker expression. The effects of viscoelastic properties of the hydrogels become more dominant than the stiffness effects in the co‐culture of hSCOs and hBVOs. In addition, more viscoelastic hydrogels can lead to more Yes‐associated protein nuclear translocation, revealing the mechanism of cell‐ECM mechano‐transduction. This research provides insights into viscoelastic behaviors of the hydrogels during human organoid patterning with ECM‐mimicking in vitro microenvironments for applications in regenerative medicine.
Optimizing Adoptive Cell Therapy for Solid Tumors via Epigenetic Regulation of T‐cell Destiny
Authors: Guo Xuemeng , Li Xiang , Wang Sijie , Shi Yingying , Huang Jiaxin , Liu Xu , Lu Yichao , Zhang Junlei , Luo Lihua , You Jian 
Published: September 2024

AbstractAdoptive cell therapy (ACT) emerged as a promising approach for cancer treatment, yet its application in solid tumors faced challenges such as inadequate tumor infiltration and cellular dysfunction. Histone acetylation is reported to play a crucial role in restoring T‐cell function within tumor tissues. Building upon previous research, a novel strategy involving the co‐loading of two drugs, G3C12 and vorinostat (SAHA), into PLGA microspheres to form G3C12+SAHA@PLGA is developed for intratumoral injection. The G3C12 peptide enhances adoptive T‐cell recruitment to the tumor site by modulating the binding state of IFN‐γ. While SAHA, a histone deacetylase inhibitor, promotes memory phenotypes of infiltrating T‐cells and prevents their transition to an exhausted state. This synergistic approach effectively augmentes the efficacy of ACT in the “cold” tumor model (4T1) or the “hot” tumor model (CT26). These findings highlight the potential of combining epigenetic regulation with recruitment signaling as a means to enhance the therapeutic impact of ACT in treating solid tumors.
Atomic‐Level Regulation of SiC4 Units Enable High Li+ Dynamics and Long‐Life Micro‐Size SiCx Anodes
Authors: Yan Zhilin , Yi Si , Wang Zhen , Ning Pengpeng , Zhang Jingwen , Huang Jinlan , Xiao Yiming , Yang Deren , Zhang Yaguang , Du Ning 
Published: September 2024

AbstractLarge‐scale applications of high‐capacity silicon‐based anodes remain a challenge for high‐energy lithium‐ion batteries (LIBs) owing to huge volume variation. Although designing nano‐sized Silicon (Si) anodes plays a milestone advance in the commercial development, it's still hindered by issues related to cost and side reactions. A simple co‐pyrolysis of SiH4 and C2H4 is introduced via chemical‐vapor‐deposition (CVD) method to prepare SiCx micro‐sized particles with atomic‐level homogeneous distributions of silicon and carbon. One basic unit of SiC4 tetrahedra in SiCx plays a key role in particles’ microstructure optimization and electrochemical performance improvement: 1) The SiC4‐enriched surface layer is found to hinder Li+ insertion. 2) Proper heat‐treatment temperature is adopted to eliminate the layer and control the transition from SiC4 to SiC nanocrystalline, which is significant for decreasing polarization, enhancing Li+ diffusion kinetics, and cycling stability. Consequently, the optimized architecture exhibits a high capacity of 1455 mA h g−1 with an outstanding capacity retention of 95.8% after 100 cycles. Pouch‐type full‐cell demonstrates that the composite possesses excellent cycling stability with capacity retentions of 82.5% after 500 cycles at 25 °C and 84.0% after 400 cycles at 45 °C. This work provides a scalable yet practical solution to micro‐sized Si‐based anodes.
Sonochemically Prepared Nanodot Magnesium Fluoride‐Based Anodeless Carbon Substrate for Simultaneously Reinforcing Interphasial and Reaction Kinetics for Sulfide‐Based All‐Solid‐State Batteries
Authors: Jeon Sang‐Jin , Hwang Chihyun , Kim Hyun‐Seung , Park Jonghyun , Hwang Jang‐Yeon , Jung Yijin , Choi Ran , Song Min‐Sang , Lee Yun Jung , Yu Ji‐Sang , Jung Yun‐Chae 
Published: September 2024

Abstract“Anodeless” electrodes for all‐solid‐state batteries (ASSBs) have been attracting attention as a solution for achieving high energy density. Recent studies on anodeless electrodes have shown improvements in cycle life and energy density through the stabilization of plated lithium (Li) using Li‐soluble metals (e.g., Ag, Zn, etc.). In this study, magnesium‐based materials (MgF2@C) are introduced for use as an anodeless electrode. Nanodot magnesium fluoride (MgF2) is synthesized onto a carbon black surface via sonochemical synthesis. MgF2 is converted to a Mg‐Li alloy and LiF during lithiation. The Mg‐Li alloy from the MgF2@C anodeless electrode reduces lithiation overpotential and provides a uniform and dense Li layer between the current collector and the anodeless electrode. The ASSB cell assembled with the MgF2@C anodeless electrode exhibits 81.4% capacity retention after 200 cycles at 30 °C.
Why insulin aspart and insulin degludec exhibit distinct release mechanisms
Authors: Li Zhuo Lin , Feng Yun Hao , Jiao Jie , Ju Xin Yu , Yu Lingyun , Zhang Guo Liang , Yu Ruixing , Chen Bo Zhi , Guo Xin Dong 
Published: September 2024

AbstractExploring the molecular mechanisms underlying insulin analogs is important for protein engineering to design innovative drug proteins. Insulin aspart (IAsp) and insulin degludec (IDeg) are representative examples of insulin analogs with distinct release profiles synthesized by targeted mutagenesis in protein engineering. Despite their importance in diabetes treatment, there remains a gap in our understanding of the molecular basis for their differential release mechanisms. In this study, ordinary molecular dynamics simulation and steered molecular dynamics are utilized to investigate the structural stability, solubility analysis, and monomer interactions of these insulins, with the aim to explain the mesoscale differences between the two insulin release mechanisms. Simulation findings have further been validated through experimental verification, shedding light on the intricate mechanisms underlying insulin release and providing valuable insights into pharmaceutical implications and potential advancements in the design of insulin therapy.
Heart Rate and Its Variability Are Associated With Resting Metabolic Rate and Substrate Oxidation in Young Women but Not in Men
Authors: Alcantara Juan M. A. , González‐Acedo Anabel , Amaro‐Gahete Francisco J. , Plaza‐Florido Abel 
Published: September 2024

ABSTRACTBackgroundThis study aims to examine the relationship between resting vagal‐related heart rate variability (HRV) parameters and heart rate (HR) with resting metabolic rate (RMR) and respiratory exchange ratio (RER) in young adults.MethodsA total of 74 young adults (22 ± 2 years old, 51 women) were included in this cross‐sectional study. HRV was assessed using a HR monitor, whereas RMR and RER were determined by indirect calorimetry.ResultsLinear regression analyses showed a positive association between HR and RER in women (standardized β = 0.384, p = 0.008), while negative associations were observed between vagal‐related HRV parameters and RER in women (β ranged from −0.262 to −0.254, all p ≤ 0.042). No significant association was found between the abovementioned physiological parameters in men.ConclusionHere, we show that HR is positively associated with RER in young women but not in men, while vagal‐related HRV parameters are inversely related to RMR, therefore suggesting a potential sexual dimorphism between cardiac rhythm and its relationship with markers of cardiometabolic health status.
Trial Registration: ClinicalTrials.gov identifier: NCT02365129.
Quantitative characterization of eosinophilia in nasal polyps with AI‐based single cell classification
Authors: Stampe Martin , Christiansen Ida Skovgaard , Backer Vibeke , Aanæs Kasper , Homøe Anne‐Sophie , Tidemandsen Jens , Nielsen Emilie Neumann , Rasmussen Sigrid Louise Hjorth , Hartvig Rasmus , Kiss Katalin , Jensen Thomas Hartvig Lindkær 
Published: September 2024

Key points
Eosinophilic granulocytes have characteristic morphological features.
This makes them prime candidates for utilization of a single cell binary classification network.
Single cell binary classification networks can reliably help quantify eosinophils in nasal polyps.
A Customized Strategy Realizes Stable Cycle of Large‐Capacity and High‐Voltage Layered Cathode for Sodium‐Ion Batteries
Authors: Peng Bo , Zhou Zihao , Shi Ji , Xu Sheng , Yang Jie , Xu Chengrong , Zuo Daxian , Xu Jie , Ma Lianbo , Guo Shaohua , Zhou Haoshen 
Published: September 2024

AbstractHigh‐voltage P2‐Na0.67Ni0.33Mn0.67O2 layered oxide cathode exhibits significant potential for sodium‐ion batteries, owing to the elevated operating voltage and theoretical energy density beyond lithium iron phosphate, but the large‐volume phase transition is the devil. Currently, this type cathode still suffers from stability–capacity trade‐off dilemma. Herein, a concept of customized strategy via multiple rock‐forming elements trace doping is presented to address the mentioned issue. The customized Mg‐Al‐Ti trace doped cathode maintains a notable capacity of 140.3 mAh g−1 with an energy density approaching 500 Wh kg−1, and shows good cycle stability, retaining 89.0 % of its capacity after 50 cycles at 0.1 C. Additionally, the full cell, paired with a hard carbon anode, achieves an advanced energy density of 303.3 Wh kg−1. The multiple characterizations reveal the failure mechanism of contrast sample involving severe intragranular cracks coupled with layer to rock salt transformation, which reduces active substance and increases charge transfer resistance. The doped sample with increased sliding energy barrier well suppresses this phenomenon. Impressively, the customized strategy can be extended to Mg‐Fe‐Ti system. This research provides a novel concept for the design of high energy sodium‐ion cathode.
Partitioning / Self‐assembly of Artificial Water Channels – Toward Controlled Permselectivity through Bilayer Membrane
Authors: Su Dan‐Dan , van der Lee Arie , Barboiu Mihail 
Published: September 2024

AbstractArtificial water channels (AWCs) have been extensively explored to mimic natural proteins, which enables to effectively transport water while blocking ions. As one of the first AWCs, self‐assembled I‐quartets (HCx) have showcased high water‐permselectivity that can be enhanced by improving their distribution and stability within membrane. The use of long alkyl chains (n>8) is constrained by their low solubility and aggregation. Herein, we considered cycloalkyl moieties, explored for the increase of the solubility favoring enhanced partition and/ for their self‐assembly behaviors resulting the formation of effective stable water‐channels with increased water permeability in bilayer membranes. This class of cycloalkyl‐ureido‐ethyl‐imidazole amphiphilic (CxUH) channel could serve as a new reference for the effective design of self‐assembled artificial water channels, it may give rise to the applications in desalination or in water treatment.
Molecular Design of Mono‐Fluorinated Ether‐Based Electrolyte for All‐Climate Lithium‐Ion Batteries and Lithium‐Metal Batteries
Authors: Xue Yejuan , Wang Yueda , Zhang Heng , Kong Weilong , Zhou Yuxin , Kang Bo , Huang Zhimei , Xiang Hongfa 
Published: September 2024

AbstractFluorinated‐ethers are promising electrolyte solvents in lithium metal batteries, for their high antioxidant and excellent reductive stability on Li anode. However, fluorinated‐ethers with high fluorination degree suffer from low ionic conductivity and narrow temperature adaptibility. Herein, we synthesize a mono‐fluorinated linear ether of bis(2‐fluoroethoxy) methane (BFME) with enhanced solvated ability. The −OCH2O− structure and fluoride substitution on the β‐C position endows the BFME electrolyte with moderate affinity to Li+, thereby improving the ionic conductivity and decreasing the Li+‐desolvation energy barrier at a wide temperature range of −60–60 °C. Additionally, the electrolyte with anion‐participated solvation structure demonstrates high film‐forming ability by forming LiF‐rich interfacial film on the electrode surfaces, rendering the graphite anode with an initial Coulombic efficiency (CE) of 94.9 % and a Li plating/stripping CE of 99.8 % by Aurbach method. Consequently, the Graphite||LiFePO4 pouch cells delivered 83.2 %, 92.5 % and 81.2 % capacity retention after 1250, 200 and 300 cycles at 25, −20 °C and 60 °C, respectively. Moreover, the Li||LFP pouch cell with 3 Ah capacity can operate for 65 cycles with 99 % capacity retention, verifying the effectiveness of the BFME electrolyte in stabilizing the interfaces and broadening the temperature adaptibility of lithium‐ion and lithium metal batteries.
Constructing Donor‐Acceptor Covalent Organic Frameworks for Highly Efficient H2O2 Photosynthesis Coupled with Oxidative Organic Transformations
Authors: Liu Jianchuan , Tuo Chao , Xiao Wei‐Yun , Qi Ming‐Yu , Yusran Yusran , Wang Zitao , Li Hui , Guo Chunsheng , Song Jialong , Qiu Shilun , Xu Yi‐Jun , Fang Qianrong 
Published: September 2024

AbstractThe development of photocatalytic systems that enable the simultaneous production of H2O2 and value‐added organic chemicals presents a dual advantage: generating valuable products while maximizing the utilization of solar energy. Despite the potential, there are relatively few reports on photocatalysts capable of such dual functions. In this study, we synthesized a series of donor‐acceptor covalent organic frameworks (COFs), designated as JUC‐675 to JUC‐677, to explore their photocatalytic efficiency in the co‐production of H2O2 and N‐benzylbenzaldimine (BBAD). Among them, JUC‐675 exhibited exceptional performance, achieving a H2O2 production rate of 22.8 mmol g−1 h−1 with an apparent quantum yield of 15.7 %, and its solar‐to‐chemical conversion efficiency was calculated to be 1.09 %, marking it as the most effective COF‐based photocatalyst reported to date. Additionally, JUC‐675 demonstrated a high selectivity (99.9 %) and yield (96 %) for BBAD in the oxidative coupling of benzylamine. The underlying reaction mechanism was thoroughly investigated through validation experiments and density functional theory (DFT) calculations. This work represents a significant advancement in the design of COF‐based photocatalysts and the development of efficient dual‐function photocatalytic platforms, offering new insights and methodologies for enhanced solar energy utilization and the synthesis of value‐added products.
Switching CO2 Electroreduction Pathways between Ethylene and Ethanol via Tuning Microenvironment of the Coating on Copper Nanofibers
Authors: Tong Xing , Zhang Pei , Chen Peng , He Zhuosen , Kang Xinchen , Yin Yaoyu , Cheng Yingying , Zhou Meng , Jing Lihong , Wang Ce , Xu Baocai , Zheng Lirong , Xing Xueqing , Wu Zhonghua , Han Buxing 
Published: September 2024

AbstractEngineering the microenvironment of electrode surface is one of the effective means to tune the reaction pathways in CO2RR. In this work, we prepared copper nanofibers with conductive polypyrrole coating by polymerization of pyrrole using polyvinyl pyrrolidone (PVP) as template. As a result, the obtained copper nanofibers Cu/Cu2+1O/SHNC, exhibited a superhydrophobic surface, which demonstrated very high selectivity for ethanol with a Faraday efficiency (FE) of 66.5 % at −1.1 V vs reversible hydrogen electrode (RHE) in flow cell. However, the catalyst Cu/Cu2+1O/NC, which was prepared under the same conditions but without PVP, possessed a hydrophobic surface and exhibited high selectivity towards ethylene at the given potentials. The mechanism for switch of reaction pathways from ethylene to ethanol in CO2RR was studied. Incorporating pyrrolidone groups into the polymer coating results in the formation of a superhydrophobic surface. This surface weakens the hydrogen bonding interaction between interfacial water molecules and facilitates the transfer of CO2, thereby enhancing the local CO2/H2O ratio. The high coverage of *CO promotes the coupling of *CO and *CHO to form C2 intermediates, and reduces the reaction energy for the formation of *CHCHOH (ethanol path) at the interface. This ensures that the reaction pathway is directed towards ethanol.
Directional Ring Translocation in a pH‐ and Redox‐Driven Tristable [2]Rotaxane
Authors: Andreoni Leonardo , Groppi Jessica , Seven Özlem , Baroncini Massimo , Credi Alberto , Silvi Serena 
Published: September 2024

AbstractWe describe the synthesis and characterization of a [2]rotaxane comprising a dibenzo‐24‐crown‐8 (DB24C8) macrocyclic component and a thread containing three recognition sites: ammonium (AmH+), bipyridinium (Bpy2+) and triazolium (Trz+). AmH+ and Bpy2+ are responsive to fully orthogonal stimuli, pH and electrochemical, which allows to precisely control the directional translation of the macrocycle along the axle. A better understanding of the processes driving the operation of the system was obtained thanks to an in‐depth thermodynamic characterization. Orthogonal stimuli responsive tristable rotaxanes represent the starting point for the creation of linear motors and the development of molecular logic gates.