bluuebunny/crossref_metadata_2025_split huggingface dataset:
Writing a linguistic symphony: Analyzing variation while doing language documentation
Authors: Meyerhoff Miriam 
Published: June 2017

AbstractTypically, a study of variation starts from the known and works its way into the unknown. But what happens when you are analyzing variation at the same time as you are grappling with the fundamental structure of the language? Whereas variationist methods often involve doing strategic violence to the data, isolating single variables, documentation tends to encourage a broader perspective. This article shows how documentation of Nkep (Central Eastern Oceanic, Vanuatu) has progressed when guided by a focus on internal and social variation. Three variables are discussed (the near merger of two front vowels, lexical borrowing, and the expression of subject agreement) to highlight the rewards and challenges associated with drawing together two subdisciplines (variation and documentation) that have not traditionally had much to say to each other. Analyzing variation alongside documentation encourages us to write ‘symphonies of variation’, as opposed to ‘sonatas’ of individual variables.
Dynamical Monte Carlo Simulations of 3-D Galactic Systems in Axisymmetric and Triaxial Potentials
Authors: Taani Ali , Vallejo Juan C. 
Published: June 2017

AbstractWe describe the dynamical behavior of isolated old ( ⩾ 1Gyr) objects-like Neutron Stars (NSs). These objects are evolved under smooth, time-independent, gravitational potentials, axisymmetric and with a triaxial dark halo. We analysed the geometry of the dynamics and applied the Poincaré section for comparing the influence of different birth velocities. The inspection of the maximal asymptotic Lyapunov (λ) exponent shows that dynamical behaviors of the selected orbits are nearly the same as the regular orbits with 2-DOF, both in axisymmetric and triaxial when (ϕ, qz)= (0,0). Conversely, a few chaotic trajectories are found with a rotated triaxial halo when (ϕ, qz)= (90, 1.5). The tube orbits preserve direction of their circulation around either the long or short axis as appeared in the triaxial potential, even when every initial condition leads to different orientations. The Poincaré section shows that there are 2-D invariant tori and invariant curves (islands) around stable periodic orbits that bound to the surface of 3-D tori. The regularity of several prototypical orbits offer the means to identify the phase-space regions with localized motions and to determine their environment in different models, because they can occupy significant parts of phase-space depending on the potential. This is of particular importance in Galactic Dynamics.
Current and future strategies for the nutritional management of cardiometabolic complications of androgen deprivation therapy for prostate cancer
Authors: Turner Lauren , Poole Karen , Faithfull Sara , Griffin Bruce A. 
Published: June 2017

AbstractAndrogen deprivation therapy (ADT) is used widely as part of a combined modality for the treatment of prostate cancer. However, ADT has also been associated with the development of cardiometabolic complications that can increase mortality from cardiovascular events. There is emerging evidence to suggest that ADT-related cardiometabolic risk can be mitigated by diet and lifestyle modification. While the clinical focus for a nutritional approach for achieving this effect is unclear, it may depend upon the timely assessment and targeting of dietary changes to the specific risk phenotype of the patient. The present review aims to address the metabolic origins of ADT-related cardiometabolic risk, existing evidence for the effects of dietary intervention in modifying this risk, and the priorities for future dietary strategies.
An Assessment of Climate Change Impacts on Los Angeles (California USA) Hospitals, Wildfires Highest Priority
Authors: Adelaine Sabrina A. , Sato Mizuki , Jin Yufang , Godwin Hilary 
Published: June 2017

AbstractIntroductionAlthough many studies have delineated the variety and magnitude of impacts that climate change is likely to have on health, very little is known about how well hospitals are poised to respond to these impacts.Hypothesis/ProblemThe hypothesis is that most modern hospitals in urban areas in the United States need to augment their current disaster planning to include climate-related impacts.MethodsUsing Los Angeles County (California USA) as a case study, historical data for emergency department (ED) visits and projections for extreme-heat events were used to determine how much climate change is likely to increase ED visits by mid-century for each hospital. In addition, historical data about the location of wildfires in Los Angeles County and projections for increased frequency of both wildfires and flooding related to sea-level rise were used to identify which area hospitals will have an increased risk of climate-related wildfires or flooding at mid-century.ResultsOnly a small fraction of the total number of predicted ED visits at mid-century would likely to be due to climate change. By contrast, a significant portion of hospitals in Los Angeles County are in close proximity to very high fire hazard severity zones (VHFHSZs) and would be at greater risk to wildfire impacts as a result of climate change by mid-century. One hospital in Los Angeles County was anticipated to be at greater risk due to flooding by mid-century as a result of climate-related sea-level rise.ConclusionThis analysis suggests that several Los Angeles County hospitals should focus their climate-change-related planning on building resiliency to wildfires.AdelaineSA, SatoM, JinY, GodwinH. An assessment of climate change impacts on Los Angeles (California USA) hospitals, wildfires highest priority. Prehosp Disaster Med. 2017;32(5):556–562.
PRIDE OR PREJUDICE?
Authors: Strother Logan , Piston Spencer , Ogorzalek Thomas 
Published: June 2017

AbstractDebates about the meaning of Southern symbols such as the Confederate battle emblem are sweeping the nation. These debates typically revolve around the question of whether such symbols represent “heritage or hatred:” racially innocuous Southern pride or White prejudice against Blacks. In order to assess these competing claims, we first examine the historical reintroduction of the Confederate flag in the Deep South in the 1950s and 1960s; next, we analyze three survey datasets, including one nationally representative dataset and two probability samples of White Georgians and White South Carolinians, in order to build and assess a stronger theoretical account of the racial motivations underlying such symbols than currently exists. While our findings yield strong support for the hypothesis that prejudice against Blacks bolsters White support for Southern symbols, support for the Southern heritage hypothesis is decidedly mixed. Despite widespread denials that Southern symbols reflect racism, racial prejudice is strongly associated with support for such symbols.
Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
Authors: Qi Nan , Shi Yuheng , Zhang Rui , Zhu Wenting , Yuan Bofeng , Li Xiaoyan , Wang Changwan , Zhang Xuewu , Hou Fajian 
Published: June 2017

AbstractIn response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggregation until viral infection. The mechanism preventing cellular MAVS from spontaneous aggregation is unclear. Here we show that multiple N-terminal truncated isoforms of MAVS are essential in preventing full-length MAVS from spontaneous aggregation through transmembrane domain-mediated homotypic interaction. Without these shorter isoforms, full-length MAVS is prone to spontaneous aggregation and Nix-mediated mitophagic degradation. In the absence of N-terminally truncated forms, blocking Nix-mediated mitophagy stabilizes full-length MAVS, which aggregates spontaneously and induces the subsequent expression of type I interferon and other proinflammatory cytokines. Our data thus uncover an important mechanism preventing spontaneous aggregation of endogenous MAVS to avoid accidental activation of antiviral innate immune signalling.
The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding
Authors: Su Chinh Tran-To , Ling Wei-Li , Lua Wai-Heng , Poh Jun-Jie , Gan Samuel Ken-En 
Published: June 2017

AbstractAntibody research has traditionally focused on heavy chains, often neglecting the important complementary role of light chains in antibody formation and secretion. In the light chain, the complementarity-determining region 3 (VL-CDR3) is specifically implicated in disease states. By modulating VL-CDR3 exposure on the scaffold through deletions in the framework region 3 (VL-FWR3), we further investigated the effects on secretion in recombinant production and antigen binding kinetics. Our random deletions of two residues in the VL-FWR3 of a Trastuzumab model showed that the single deletions could impact recombinant production without significant effect on Her2 binding. When both the selected residues were deleted, antibody secretion was additively decreased, and so was Her2 binding kinetics. Interestingly, we also found allosteric effects on the Protein L binding site at VL-FWR1 elicited by these deletions in VL- FWR3. Together, these findings demonstrate the importance of light chain FWR3 in antigen binding, recombinant production, and antibody purification using Protein L.
The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells
Authors: Ge Chun , Cao Bei , Feng Dong , Zhou Fang , Zhang Jingwei , Yang Na , Feng Siqi , Wang Guangji , Aa Jiye 
Published: June 2017

AbstractAdriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, the biochemical process and underlying mechanisms are not clear. Our previous study revealed that ADR increased reactive oxygen species (ROS) generation and decreased glutathione (GSH) biosynthesis, while N-acetylcysteine, the ROS scavenger, reversed the over-expression of P-gp. The present study showed that ADR inhibited the influx of cystine (the source material of GSH) and the activity of the SLC7A11 transporter (in charge of cystine uptake) in MCF-7 cells. For the first time, we showed that the down-regulation/silence of SLC7A11, or cystine deprivation, or enhanced ROS exposure significantly increased P-gp expression in MCF-7 cells. The down-regulation of SLC7A11 markedly enhanced ROS induced P-gp over-expression and drug resistance in MCF-7 cells; a combination of either an inhibited/silenced SLC7A11 or cystine deprivation and increased ROS dramatically promoted P-gp expression, which could be reversed by N-acetylcysteine. In contrast, the over-expression of SLC7A11, or supplementation with sufficiently cystine, or treatment with N-acetylcysteine significantly decreased P-gp expression and activity. It was suggested that ROS and SLC7A11/cystine were the two relevant factors responsible for the expression and function of P-gp, and that SLC7A11 might be a potential target modulating ADR resistance.
Mechanical characterization and cleaning of CVD single-layer h-BN resonators
Authors: Cartamil-Bueno Santiago J. , Cavalieri Matteo , Wang Ruizhi , Houri Samer , Hofmann Stephan , van der Zant Herre S. J. 
Published: June 2017

AbstractHexagonal boron nitride is a 2D material whose single-layer allotrope has not been intensively studied despite being the substrate for graphene electronics. Its transparency and stronger interlayer adhesion with respect to graphene makes it difficult to work with, and few applications have been proposed. We have developed a transfer technique for this extra-adhesive material that does not require its visual localization, and fabricated mechanical resonators made out of chemical vapor-deposited single-layer hexagonal boron nitride. The suspended material was initially contaminated with polymer residues from the transfer, and the devices showed an unexpected tensioning when cooling them to 3 K. After cleaning in harsh environments with air at 450 °C and ozone, the temperature dependence changed with f0Q products reaching 2 × 1010 Hz at room temperature. This work paves the way to the realization of highly sensitive mechanical systems based on hexagonal boron nitride, which could be used as an alternative material to SiN for optomechanics experiments at room temperature.
Single‐layer narrow‐band beam splitter based on a transparent grating with high‐spectral contrast and high‐angle sensitivity
Authors: Zhang Jian , Zhang Xinping 
Published: June 2017

A report on the polarisation beam splitter with high‐angle‐resolved tunability in the visible spectrum, which was achieved in a single layer of transparent thin film of indium‐tin‐oxide (ITO). One‐dimensional grating structures were etched into an ITO layer with a designed depth using inductively coupled plasma, where the remaining ITO acts as a waveguide. Enhanced reflection of light was observed when the retro‐diffraction was overlapped with the waveguide resonance mode. A beam splitting ratio of 1:1 was achieved at 532 nm at a specific incident angle. This is a stable and efficient beam splitter with high contrast and narrow‐band response. It can also be applied as tunable narrow‐band filters, angle sensors or optical switch.
Oxygen Saturation in Pulse Oximetry in Hemoglobin Anomalies
Authors: Zur B. , Bagci S. , Ludwig M. , Stoffel-Wagner B. 
Published: June 2017

AbstractPulse oximetry is an essential diagnostic method in pediatric emergency medicine and pediatric intensive care. However, if undetected hemoglobin anomalies are the underlying cause measurements of low oxygen saturation can be interpreted incorrectly or may lead to unnecessary examinations. In 2 recently discovered hemoglobin anomalies, Hb Bonn and Hb Venusberg, this resulted in extensive and repeat cardiopulmonary examinations. This review aims to provide an overview of hemoglobin anomalies causing low oxygen saturation.We describe the methods required for differential diagnosis of hemoglobin anomalies, such as hemoglobin electrophoresis, High Performance Liquid Chromatography, hemoglobin gene sequencing and spectral photometry, and the difficulties with the interpretation of results. Furthermore, with a review of the literature we provide an extensive overview of hemoglobin anomalies which result in low oxygen saturation measurement in pulse oximetry. With the examples of Hb Bonn, a novel hemoglobin mutation of the proximal α1-globin, which results in false low pulse oximetry measurements of oxygen saturation, and Hb Venusberg, a low oxygen-affine hemoglobin mutation of the β-globin, we highlight the difficulties arising from the respective case histories.In pediatric medicine, hemoglobin anomalies must be included in the diagnosis as a possible underlying cause of low oxygen saturation in case of ambiguous or conflicting pulse oximetry findings.
Preliminary Data from a Field Trial of the PFA-100™ System
Authors: Mammen Eberhard , Alshameeri Rasheed , Comp Philip 
Published: June 2017

The PFA-100™ system *(Dade International Inc., Miami, FL) is a platelet function anaIyzer, the design of which is based on the technology of the Thrombostat 4000 VDG, Seeon, Germany. † It was developed to measure primary, platelet dependent hemostasis in citrated whole blood in vitro. A first pilot study was conducted with the instrument to assess performance characteristics. Healthy subjects (normals) who had not ingested any medications, and patients (abnormals) with primary, platelet-related hemostasis defects, which included users of aspirin, were studied with two test cartridges; collagen/ADP and collagen/epinephrine. Before the study certain variables were tested that ascertained that blood drawn into either 3.8% or 3.2% sodium citrate containing vacutainers (rather than syringes) could be used for testing. Tests must be performed within a five-hour time span from drawing to testing, and blood must be kept at room temperature. Normal reference values were 77–133 seconds closure times for collagen/ADP and 98-185 seconds for collagen/ epinephrine. Precision testing revealed a CV of >10% for within-day and between-day (five days) analyses on collagen/ADP cartridges and a CV of 5–14% for both runs on the collagen/epinephrine cartridges. No clinically important differences were found between measurements in the two positions of the instrument, although one follows the other. Tests on 99 normals and 70 abnormals were performed and data expressed as receiver/operator characteristics (ROC) curves that assess the combined sensitivity and specificity of a procedure. An area under the curve of 1.0 means that all samples (normals + abnormals) were accurately identified; a value of 0.5 indicates that the test is noninformative. Using collagen/ADP cartridges a value of 0.76 was found when testing 99 normals and 52 abnormals. All aspirin users had been omitted from the abnormals. With the collagen/epinephrine cartridges, evaluating 99 normals and 70 abnormals, a value of 0.89 was obtained. This analysis entailed also aspirin users. Of 24 known aspirin users the collagen/epinephrine cartridges identified 20 that had normal closure times with the collagen/ADP cartridges. Three aspirin users had abnormal values with both cartridges, one subject was normal with both. When the traditional Ivy bleeding times were plotted as an ROC curve, an area under the curve of 0.698 was found. The data suggest that the PFA-100™ system identifies normals and abnormals (subjects with primary, platelet related hemostasis defects) with greater sensitivity and specificity than the present widely used bleeding time. The instrument is easy to use and could be adapted to routine laboratory use. The data presented are preliminary and need to be confirmed by additional testing.†Not commercially available in the U.S.A.
Hamartomatous Polyps and Associated Syndromes
Authors: Cone Molly 
Published: June 2017

AbstractHamartomatous polyps of the gastrointestinal tract can occur sporadically, however, for several hereditary syndromes, their presence is one of the major clinical features. Peutz–Jeghers syndrome, juvenile polyposis syndrome, and the PTEN hamartoma syndromes are autosomal dominant inherited disorders that predispose to formation of such polyps, especially in the colon and rectum. These can lead to increased colorectal cancer risk and should be followed and managed appropriately. In this article, the three major hereditary hamartomatous syndromes are described, including presentation, colorectal surveillance, and management.
Can Mean Platelet Volume Be Used as a Predictor of Vascular Disease? Problems and Pitfalls
Authors: Laffan Mike , Arachchillage Deepa 
Published: June 2017

AbstractPlatelets play a pivotal role in both hemostasis and thrombosis. Increased platelet volume has several etiologies and may be secondary to a genetic variant, platelet activation, increased platelet turnover, or in response to inflammatory stimuli. There are several hereditary syndromes in which an increased mean platelet volume (MPV) occurs in association with a reduction in platelet number and function. An acquired increase in platelet size is often associated with increased platelet reactivity, shortened bleeding time, and increased platelet aggregation. Many studies have shown that high MPV is associated with increased risk of venous and arterial thrombosis, but genome-wide association analyses found a weak inverse association between the risk of coronary heart disease and MPV. The disease associations of MPV suggest that it could provide a useful contribution to risk assessment algorithms for both venous thromboembolism and arterial thrombosis. However, owing to the problems associated with reliably assessing MPV, it does not yet constitute a practically useful biomarker for this purpose. Before MPV can be adopted for wider clinical use, the methodological problems involved in obtaining accurate and interlaboratory comparable results must be resolved. In particular, a major degree of standardization is required, as are local reference ranges calculated with respect to specified time intervals from venipuncture to laboratory analysis. We discuss here the potential role of MPV in predicting the risk of acquired thrombotic disorders in addition to roles in congenital thrombocytopenic disorders, as well as the problems and pitfalls associated with use of MPV in these settings.
Inferior Vena Cava Agenesis and Deep Vein Thrombosis in the Young: A Review of the Literature and Local Experience
Authors: Cannavacciuolo Francesca , Gianno Adriana , Cerbone Anna , Mangiacapra Sara , Coppola Antonio , Amitrano Maria , Tufano Antonella 
Published: June 2017

AbstractCongenital agenesis of the inferior vena cava (AIVC) is a rare vascular abnormality with a prevalence of 0.0005 to 1% in the general population. This condition is found in almost 5% of young patients (younger than 30 years) with proximal, typically bilateral, deep venous thrombosis (DVT) of the lower limbs, often in the absence of apparent risk factors. However, AIVC in young patients with DVT is probably underestimated because AIVC cannot be detected by the standard DVT diagnostic workup. Inherited thrombophilia has been reported in patients with AIVC-associated DVT, as an additional risk factor, but its role is poorly investigated. The best therapeutic strategy and the optimal duration of anticoagulant treatment of DVT in patients with AIVC are still unclear. Here, we describe 14 young patients (2 females and 12 males, mean age at first DVT: 27.8 ± 10.1 years), with color Doppler ultrasound (US) and abdominal computed tomography scan confirmed AIVC-associated DVT and discuss their characteristics in the framework of a literature review on this topic. Our patients were mainly males (10/12) and experienced proximal DVT events, not complicated by pulmonary embolism. DVT-precipitating factors were detected only in five cases, the two female patients (oral contraceptives and puerperium), and three male patients (one after leg fracture and two after abdominal surgery). Thrombophilic abnormalities were found in eight patients (heterozygous factor V Leiden mutation, n = 3; mild/moderate hyperhomocysteinemia, n = 3; reduced protein C activity, n = 1; antiphospholipid syndrome, n = 1). The majority of patients (13/14) were treated with long-term oral anticoagulant therapy and elastic stockings (ES), with a very low rate of DVT recurrence (1/14, mean follow-up 7 years). These clinical characteristics were largely consistent with those of 161 patients identified by review of the literature. On the whole, although many aspects are still poorly known, our case series and literature review suggest that a search should be undertaken for AIVC in young patients with proximal idiopathic, particularly when bilateral, DVT, which should then be treated with prolonged anticoagulation and ES.
Network dynamics of social influence in the wisdom of crowds
Authors: Becker Joshua , Brackbill Devon , Centola Damon 
Published: June 2017

SignificanceSince the discovery of the wisdom of crowds over 100 years ago theories of collective intelligence have held that group accuracy requires either statistical independence or informational diversity among individual beliefs. Empirical evidence suggests that allowing people to observe the beliefs of others leads to increased similarity of individual estimates, reducing independence and diversity without a corresponding increase in group accuracy. As a result, social influence is expected to undermine the wisdom of crowds. We present theoretical predictions and experimental findings demonstrating that, in decentralized networks, social influence generates learning dynamics that reliably improve the wisdom of crowds. We identify general conditions under which influence, not independence, produces the most accurate group judgments.