bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between superconductivity and bond angle of CrAs chain in non-centrosymmetric compounds A2Cr3As3 (A = K, Rb)
Authors: Wang Zhe , Yi Wei , Wu Qi , Sidorov Vladimir A. , Bao Jinke , Tang Zhangtu , Guo Jing , Zhou Yazhou , Zhang Shan , Li Hang , Shi Youguo , Wu Xianxin , Zhang Ling , Yang Ke , Li Aiguo , Cao Guanghan , Hu Jiangping , Sun Liling , Zhao Zhongxian 
Published: November 2016

AbstractNon-centrosymmetric superconductors, whose crystal structure is absent of inversion symmetry, have recently received special attentions due to the expectation of unconventional pairings and exotic physics associated with such pairings. The newly discovered superconductors A2Cr3As3 (A = K, Rb), featured by the quasi-one dimensional structure with conducting CrAs chains, belongs to such kind of superconductor. In this study, we are the first to report the finding that superconductivity of A2Cr3As3 (A = K, Rb) has a positive correlation with the extent of non-centrosymmetry. Our in-situ high pressure ac susceptibility and synchrotron x-ray diffraction measurements reveal that the larger bond angle of As-Cr-As (defined as α) in the CrAs chains can be taken as a key factor controlling superconductivity. While the smaller bond angle (defined as β) and the distance between the CrAs chains also affect the superconductivity due to their structural connections with the α angle. We find that the larger value of α-β, which is associated with the extent of the non-centrosymmetry of the lattice structure, is in favor of superconductivity. These results are expected to shed a new light on the underlying mechanism of the superconductivity in these Q1D superconductors and also to provide new perspective in understanding other non-centrosymmetric superconductors.
Multicolor Colormetric Biosensor for the Determination of Glucose based on the Etching of Gold Nanorods
Authors: Lin Yue , Zhao Mengmeng , Guo Yajuan , Ma Xiaoming , Luo Fang , Guo Longhua , Qiu Bin , Chen Guonan , Lin Zhenyu 
Published: November 2016

AbstractIn this work, 3,3′,5,5′-tetramethylbenzidine(II) (TMB2+), derived from H2O2-horseradish peroxidase (HRP)-3,3′,5,5′-tetramethylbenzidine (H2O2-HRP-TMB) reaction system, was used to etch AuNRs to generate different colors of solution. Many enzyme reactions are involved in the production of H2O2 (e.g., glucose can react with the dissolved oxygen in the presence of glucose oxidase (GOx) to produce H2O2). Given this information, a simple visual biosensor was developed in this study, with glucose as the example target. The detection range of the proposed system varied with the experimental conditions, such as the concentration of GOx and HRP, and enzymatic reaction time. Under the optimized conditions, the longitudinal shift of localized surface plasmon resonances (LSPR) had a linear correlation with the glucose concentration in the range of 0.1~1.0 mM. Meanwhile, the solution displayed a specific color in response to the glucose concentration, thus enabling the visual quantitative detection of glucose at a glance. Compared with the traditional monochromic colorimetry, this multicolor glucose sensor generates various vivid colors, which can be easily distinguished by naked eyes without any sophisticated instrument. Notably, the proposed method has been successfully applied to detect glucose in serum samples with satisfied results.
Curvature-driven bubbles or droplets on the spiral surface
Authors: Li Shanpeng , Liu Jianlin , Hou Jian 
Published: November 2016

AbstractDirectional motion of droplets or bubbles can often be observed in nature and our daily life, and this phenomenon holds great potential in many engineering areas. The study shows that droplets or bubbles can be driven to migrate perpetually on some special substrates, such as the Archimedean spiral, the logarithmic spiral and a cantilever sheet in large deflection. It is found that a bubble approaches or deviates from the position with highest curvature of the substrate, when it is on the concave or convex side. This fact is helpful to explain the repelling water capability of Nepenthes alata. Based on the force and energy analysis, the mechanism of the bubble migration is well addressed. These findings pave a new way to accurately manipulate droplet or bubble movement, which bring inspirations to the design of microfluidic and water harvesting devices, as well as oil displacement and ore filtration.
Comparison of the effect on bone healing process of different implants used in minimally invasive plate osteosynthesis: limited contact dynamic compression plate versus locking compression plate
Authors: Xue Zichao , Xu Haitao , Ding Haoliang , Qin Hui , An Zhiquan 
Published: November 2016

AbstractMinimally invasive plate osteosynthesis (MIPO) has been widely accepted because of its satisfactory clinical outcomes. However, the implant construct that works best for MIPO remains controversial. Different plate designs result in different influence mechanisms to blood flow. In this study, we created ulnar fractures in 42 beagle dogs and fixed the fractures using MIPO. The dogs were randomly divided into two groups and were fixed with a limited contact dynamic compression plate (LC-DCP) or a locking compression plate (LCP). Our study showed that with MIPO, there was no significant difference between the LCP and the LC-DCP in terms of fracture fixation, bone formation, or mineralization. Combined with the previous literature, we inferred that the healing process is affected by the quality of fracture reduction more than plate selection.
Electrospray deposition device used to precisely control the matrix crystal to improve the performance of MALDI MSI
Authors: Li Shilei , Zhang Yangyang , Liu Jian’an , Han Juanjuan , Guan Ming , Yang Hui , Lin Yu , Xiong Shaoxiang , Zhao Zhenwen 
Published: November 2016

AbstractMALDI MSI has been recently applied as an innovative tool for detection of molecular distribution within a specific tissue. MALDI MSI requires deposition of an organic compound, known as matrix, on the tissue of interest to assist analyte desorption and ionization, in which the matrix crystal homogeneity and size greatly influence the imaging reproducibility and spatial resolution in MALDI MSI. In this work, a homemade electrospray deposition device was developed for deposition of matrix in MALDI MSI. The device could be used to achieve 1 μm homogeneous matrix crystals in MALDI MSI analysis. Moreover, it was found, for the first time, that the electrospray deposition device could be used to precisely control the matrix crystal size, and the imaging spatial resolution was increased greatly as the matrix crystals size becoming smaller. In addition, the easily-built electrospray deposition device was durable for acid, base or organic solvent, and even could be used for deposition of nanoparticles matrix, which made it unparalleled for MALDI MSI analysis. The feasibility of the electrospray deposition device was investigated by combination with MALDI FTICR MSI to analyze the distributions of lipids in mouse brain and liver cancer tissue section.
Contributory roles of two l-lactate dehydrogenases for l-lactic acid production in thermotolerant Bacillus coagulans
Authors: Sun Lifan , Zhang Caili , Lyu Pengcheng , Wang Yanping , Wang Limin , Yu Bo 
Published: November 2016

AbstractThermotolerant Bacillus coagulans is considered to be a more promising producer for bio-chemicals, due to its capacity to withstand harsh conditions. Two L-lactate dehydrogenase (LDH) encoding genes (ldhL1 and ldhL2) and one D-LDH encoding gene (ldhD) were annotated from the B. coagulans DSM1 genome. Transcriptional analysis revealed that the expression of ldhL2 was undetectable while the ldhL1 transcription level was much higher than that of ldhD at all growth phases. Deletion of the ldhL2 gene revealed no difference in fermentation profile compared to the wild-type strain, while ldhL1 single deletion or ldhL1ldhL2 double deletion completely blocked L-lactic acid production. Complementation of ldhL1 in the above knockout strains restored fermentation profiles to those observed in the wild-type strain. This study demonstrates ldhL1 is crucial for L-lactic acid production and NADH balance in B. coagulans DSM1 and lays the fundamental for engineering the thermotolerant B. coagulans strain as a platform chemicals producer.
Evolution of gossip-based indirect reciprocity on a bipartite network
Authors: Giardini Francesca , Vilone Daniele 
Published: November 2016

AbstractCooperation can be supported by indirect reciprocity via reputation. Thanks to gossip, reputations are built and circulated and humans can identify defectors and ostracise them. However, the evolutionary stability of gossip is allegedly undermined by the fact that it is more error-prone that direct observation, whereas ostracism could be ineffective if the partner selection mechanism is not robust. The aim of this work is to investigate the conditions under which the combination of gossip and ostracism might support cooperation in groups of different sizes. We are also interested in exploring the extent to which errors in transmission might undermine the reliability of gossip as a mechanism for identifying defectors. Our results show that a large quantity of gossip is necessary to support cooperation, and that group structure can mitigate the effects of errors in transmission.
Nitric oxide triggers a transient metabolic reprogramming in Arabidopsis
Authors: León José , Costa Álvaro , Castillo Mari-Cruz 
Published: November 2016

AbstractNitric oxide (NO) regulates plant growth and development as well as responses to stress that enhanced its endogenous production. Arabidopsis plants exposed to a pulse of exogenous NO gas were used for untargeted global metabolomic analyses thus allowing the identification of metabolic processes affected by NO. At early time points after treatment, NO scavenged superoxide anion and induced the nitration and the S-nitrosylation of proteins. These events preceded an extensive though transient metabolic reprogramming at 6 h after NO treatment, which included enhanced levels of polyamines, lipid catabolism and accumulation of phospholipids, chlorophyll breakdown, protein and nucleic acid turnover and increased content of sugars. Accordingly, lipid-related structures such as root cell membranes and leaf cuticle altered their permeability upon NO treatment. Besides, NO-treated plants displayed degradation of starch granules, which is consistent with the increased sugar content observed in the metabolomic survey. The metabolic profile was restored to baseline levels at 24 h post-treatment, thus pointing up the plasticity of plant metabolism in response to nitroxidative stress conditions.
TrackNTrace: A simple and extendable open-source framework for developing single-molecule localization and tracking algorithms
Authors: Stein Simon Christoph , Thiart Jan 
Published: November 2016

AbstractSuper-resolution localization microscopy and single particle tracking are important tools for fluorescence microscopy. Both rely on detecting, and tracking, a large number of fluorescent markers using increasingly sophisticated computer algorithms. However, this rise in complexity makes it difficult to fine-tune parameters and detect inconsistencies, improve existing routines, or develop new approaches founded on established principles. We present an open-source MATLAB framework for single molecule localization, tracking and super-resolution applications. The purpose of this software is to facilitate the development, distribution, and comparison of methods in the community by providing a unique, easily extendable plugin-based system and combining it with a novel visualization system. This graphical interface incorporates possibilities for quick inspection of localization and tracking results, giving direct feedback of the quality achieved with the chosen algorithms and parameter values, as well as possible sources for errors. This is of great importance in practical applications and even more so when developing new techniques. The plugin system greatly simplifies the development of new methods as well as adapting and tailoring routines towards any research problem’s individual requirements. We demonstrate its high speed and accuracy with plugins implementing state-of-the-art algorithms and show two biological applications.
TDB protects vascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced injury by targeting miR-34a to increase Bcl-2 expression
Authors: Liao Li-Xi , Zhao Ming-Bo , Dong Xin , Jiang Yong , Zeng Ke-Wu , Tu Peng-Fei 
Published: November 2016

AbstractProlonged ischemia can result in apoptotic death of vascular endothelial cells and lead to ischemic vascular diseases including vascular dementia, arteriosclerosis and brain oedema. Finding protective strategies to prevent this is therefore an urgent mission. Recent studies have shown that dysregulation of microRNAs (miRNAs) can lead to imbalance of Bcl-2 family proteins and mitochondrial dysfunction, leading to further damage of vascular cells under ischemic conditions. However, whether miRNAs can be used as a drug target for treating vascular diseases is not fully understood. In this study, we observed that the natural product 2,4,5-trihydroxybenzaldehyde (TDB) could effectively inhibit vascular cell apoptosis following oxygen-glucose deprivation/reperfusion (OGD/R) by maintaining mitochondrial membrane potential (MMP) and suppressing activation of the mitochondria-dependent caspase-9/3 apoptosis pathway. Furthermore, we identified miR-34a, a crucial negative regulator of Bcl-2, as a target for the protective effect of TDB on vascular cells. TDB-induced suppression of miR-34a resulted in a significant upregulation of Bcl-2 protein, MMP maintenance, and the survival of vascular cells following OGD/R. Our findings suggest that targeting miR-34a with the natural product TDB may provide a novel strategy for the treatment of ischemic vascular injuries, and demonstrate the therapeutic potential in targeting miRNAs using appropriate small molecules.
Anomalous Light Scattering by Topological PT-symmetric Particle Arrays
Authors: Ling C. W. , Choi Ka Hei , Mok T. C. , Zhang Zhao-Qing , Fung Kin Hung 
Published: December 2016

AbstractRobust topological edge modes may evolve into complex-frequency modes when a physical system becomes non-Hermitian. We show that, while having negligible forward optical extinction cross section, a conjugate pair of such complex topological edge modes in a non-Hermitian "Equation missing"-symmetric system can give rise to an anomalous sideway scattering when they are simultaneously excited by a plane wave. We propose a realization of such scattering state in a linear array of subwavelength resonators coated with gain media. The prediction is based on an analytical two-band model and verified by rigorous numerical simulation using multiple-multipole scattering theory. The result suggests an extreme situation where leakage of classical information is unnoticeable to the transmitter and the receiver when such a "Equation missing"-symmetric unit is inserted into the communication channel.
Dual-wavelength single-frequency laser emission in asymmetric coupled microdisks
Authors: Wang Haotian , Liu Sheng , Chen Lin , Shen Deyuan , Wu Xiang 
Published: December 2016

AbstractThe gain and loss in a microcavity laser play an important role for the modulation of laser spectrum. We show that dual-wavelength single mode lasing can be achieved in an asymmetric coupled system consisted of two size-mismatched microdisks. The amount of eigenmodes in this coupled-microdisk system is reduced relying on the Vernier effect. Then a single mode is selected to lase by controlling the gain branching in the supermodes. The supermodes are formed by the coupling between different transverse whispering-gallery modes (WGMs). When the gain/loss status between the two mirodisks is changed through selectively pumping process, the modulated gain branching for various supermodes leads to the switchable single-frequency laser emission. The results obtained in this work will provide the further understand for the spectral modulation mechanism in the coupled microcavity laser system.
NANOG regulates epithelial–mesenchymal transition and chemoresistance in ovarian cancer
Authors: Qin Shan , Li Yanfang , Cao Xuexia , Du Jiexian , Huang Xianghua 
Published: November 2016

A key transcription factor associated with poor prognosis and resistance to chemotherapy in ovarian cancer is NANOG. However, the mechanism by which NANOG functions remains undefined. It has been suggested that epithelial-to-mesenchymal transition (EMT) also contributes to development of drug resistance in different cancers. We thus determined whether NANOG expression was associated with EMT and chemoresistance in epithelial ovarian cancer cells. NANOG expression was increased in epithelial ovarian cancer cell lines compared with its expression in normal epithelial ovarian cell lines. NANOG expression in SKOV-3 or OV2008 cells directly correlated with high expression of mesenchymal cell markers and inversely with low expression of epithelial cell marker. RNAi-mediated silencing of NANOG in SKOV-3 reversed the expression of mesenchymal cell markers and restored expression of E-cadherin. Reversibly, stable overexpression of NANOG in Moody cells increased expression of N-cadherin whereas down-regulating expression of E-cadherin, cumulatively indicating that NANOG plays an important role in maintaining the mesenchymal cell markers. Modulating NANOG expression did not have any effect on proliferation or colony formation. Susceptibility to cisplatin increased in SKOV-3 cells on down-regulating NANOG and reversible results were obtained in Moody cells post-overexpression of NANOG. NANOG silencing in SKOV-3 and OV2008 robustly attenuated in vitro migration and invasion. NANOG expression exhibited a biphasic pattern in patients with ovarian cancer and expression was directly correlated to chemoresistance retrospectively. Cumulatively, our data demonstrate that NANOG expression modulates chemosensitivity and EMT resistance in ovarian cancer.
Design of novel multiband folded printed quadrifilar helical antenna for GPS/WLAN applications
Authors: Khajepour Somayeh , Ghaffarian Mohammad Saeid , Moradi Gholamreza 
Published: November 2016

A tunable multiband folded printed quadrifilar helical antenna (FPQHA) is proposed. Creating slot on the arms of FPQHA is a simple approach for designing multiband helical antenna. Also varying width and length of the slot can cause to tune the interested frequency bands. The operating frequency ranges in L/S/C band that covers L1 GPS band and most of the commercial wireless communication systems, such as WLAN [IEEE 802.11 (2.4/3.6/5 GHz)], LTE and WiMAX (2.5/3.5 GHz).
Kant on animal and human pleasure
Authors: Newton Alexandra 
Published: November 2016

AbstractFeeling, for any animal, is a faculty of comparing objects or representations with regard to whether they promote its vital powers (pleasure) or hinder them (displeasure). But whereas these comparisons presuppose a species-concept in non-rational animals, nature has not equipped the human being with a universal principle or life-form that would determine what agrees or disagrees with it. As humans, we must determine our mode of life for ourselves. Contrary to other interpretations, I argue that this places the human capacity for pleasure and displeasure outside of nature and in a realm of spirit.
Anecdote of the Ōmura laboratory and the discovery of avermectin
Authors: Iwai Yuzuru 
Published: November 2016

Abstract
I first met Professor Ōmura, Distinguished Emeritus Professor, at The Kitasato Institute (Kitaken) when I was 28 years old. Since then, he has been my respectful supervisor as well as mentor. Looking back on those memories, I am deeply honored to write about the discovery and development of avermectin.
Pursuing the unlimited potential of microorganisms—progress and prospect of a fermentation company†
Authors: Arisawa Akira , Watanabe Azuma 
Published: November 2016

Abstract
Production of pharmaceuticals and chemicals using microbial functions has bestowed numerous benefits onto society. The Nobel Prize awarded to Professor Ōmura, Distinguished Emeritus Professor of Kitasato University, showed the world the importance of the discovery and practical application of microorganisms. Now, increasing attention is turned toward the future path of this field. As people involved in the microorganism industry, we will review the industrial activities thus far and consider the possible future developments in this field and its potential contribution to society.
Epoch-making milestones in antibiotic exploratory researches in Japan†
Authors: Hotta Kunimoto 
Published: November 2016

Abstract
Professor Satoshi Ōmura was awarded the 2015 Nobel Prize in Physiology or Medicine. He is the third to win the award for research on antibiotic, following Fleming’ (UK, 1945, discovery of penicillin) and Waksman (USA, 1952, discovery of streptomycin), and the second person after Waksman to receive the award for research on actinomycetes. By focusing his research on macrolides stemming from leucomycin research rather than β-lactams like penicillin or aminoglycosides like streptomycin, Prof. Ōmura realized many scientific achievements. These efforts finally led to the discovery of avermectin and its semi-synthetic derivative, ivermectin, considered a monumental contribution to the human race. In this manuscript, I will outline the chronicles of the epoch-making antibiotic exploratory researches preceding Prof. Ōmura.
Decomposition products of glycidyl esters of fatty acids by heating
Authors: Kimura Wataru , Endo Yasushi 
Published: November 2016

AbstractIn this study, decomposition products of glycidyl palmitate (GP) of fatty acids heated at high temperature such as deep frying were investigated. When GP and tripalmitin (TP) were heated at 180 and 200 °C, they were decreased with heating time. The weight of GP was less than that of TP, although both GP and TP were converted to polar compounds after heating. The decomposition rate of GP was higher than TP. Both GP and TP produced considerable amounts of hydrocarbons and aldehydes during heating. Aldehydes produced from GP and TP included saturated aldehydes with carbon chain length of 3–10, while hydrocarbons consisted of carbon chain length of 8–15. It was observed that major hydrocarbons produced from GP during heating were pentadecane. Moreover, the level of carbon dioxide (CO2) released from GP was higher than that of TP. It was suggested that fatty acids in GE might be susceptible to decarboxylation. From these results, GP might be quickly decomposed to hydrocarbons, aldehydes and CO2 besides polar compounds by heating, in comparison with TP.
Leading terms of anticyclotomic Stickelberger elements and 𝑝-adic periods
Authors: Bergunde Felix , Gehrmann Lennart 
Published: November 2016

Let

E
E

be a quadratic extension of a totally real number field. We construct Stickelberger elements for Hilbert modular forms of parallel weight 2 in anticyclotomic extensions of

E
E

. Extending methods developed by Dasgupta and Spieß from the multiplicative group to an arbitrary one-dimensional torus we bound the order of vanishing of these Stickelberger elements from below and, in the analytic rank zero situation, we give a description of their leading terms via automorphic

L

\mathcal {L}

-invariants. If the field

E
E

is totally imaginary, we use the

p
p

-adic uniformization of Shimura curves to show the equality between automorphic and arithmetic

L

\mathcal {L}

-invariants. This generalizes a result of Bertolini and Darmon from the case that the ground field is the field of rationals to arbitrary totally real number fields.