bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurological conditions and community-based physical activity: physical therapists’ belief and actions
Authors: Declerck Louise , Gillot Mathilde , Goffaux Charlotte , Kaux Jean-François , Stoquart Gaetan 
Published: September 2024

Introduction: Physical therapists (PTs) are key actors in physical activity (PA) promotion. However, it remains unclear whether PTs in community settings promote community-based PA such as adapted physical activity (APA) and adaptive sports (AS) to their patients with neurological conditions (NCs). The main purposes were to evaluate the beliefs PTs have of APA and AS, and to explore actions they undertake to promote it to their patients with NCs.
Methods: An online survey was created specifically for the study. PT associations and institutions were contacted and licensed PTs working in community-based settings, treating at least one patient with a NC, were invited to participate. Questionnaires were analyzed only if all mandatory questions had been answered.
Results: A total of 165 questionnaires were analyzed. PTs reported prioritizing active treatment. They viewed APA and AS as beneficial for their patients with NCs; however, its promotion remained largely infrequent due to a number of barriers. The PTs’ own level of PA seemed to significantly influence their beliefs of the benefits of APA and AS (p = 0.001), while being specialized in neurologic physical therapy enabled the PTs to increase frequency of promotion (p = 0.003).
Conclusion: Though community-based PTs are aware of the importance of PA for individuals with NCs, they face difficulties in promoting it to their patients. However, these difficulties are reduced among PTs who are specialized in neurologic physical therapy. Efforts should be made toward educating PTs to neurological pathologies and their specificities when it comes to PA.
Enhancement of apoptosis in Caco-2, Hep-G2, and HT29 cancer cell lines following exposure to Toxoplasma gondii peptides
Authors: Shahrivar Firooz , Sadraei Javid , Pirestani Majid , Ahmadpour Ehsan 
Published: September 2024

Objective: Cancer or neoplasm is a cosmopolitan catastrophe that results in more than 20 million new cases and 10 million deaths every year. Some factors lead to carcinogenesis like infectious diseases. Parasites like Toxoplasma gondii, by its components, could modulate the cancer system by inducing apoptosis. The objective of this investigation is to assess the potential of peptides derived from T. gondii in combating cancer by examining their effects on Caco-2, Hep-G2, and HT29 cell lines.
Materials and methods: Candidate peptide by its similarity to anticancer compounds was predicted through the computer-based analysis/platform. The impact of the peptide on cell viability, cell proliferation, and gene expression was evaluated through the utilization of MTT assay, flow cytometry, and real-time polymerase chain reaction (PCR) methodologies.
Results: The cell viability rate exhibited a significant decrease (p < 0.001) across all cell lines when exposed to a concentration of ≤160 μg. Within the 48-hour timeframe, the half maximal inhibitory concentration (IC50) for HT29 and Hep-G2 cell lines was determined to be 107.2 and 140.6 μg/mL, respectively. Notably, a marked decrease in the expression levels of Bcl2 and APAF1 genes was observed in both the Hep-G2 and HT29 cell lines.
Conclusion: These findings indicate that the T. gondii peptide affected cancer cell mortality and led to changes in the expression of genes associated with apoptosis.
Aplicabilidade da fitoterapia em pacientes em cuidados paliativos: Uma revisão integrativa da literatura
Authors: Oliveira Milena da Silva , Santos Kyvia Naysis de Araujo , Cunha Kayron Rodrigo Ferreira , Paula Apolinário da Silva Ana , Moura Luiz Francisco Wemmenson Gonçalves , Nascimento José Eranildo Teles do 
Published: September 2024

A fitoterapia é uma terapia complementar que faz uso de plantas medicinais para prevenção e reabilitação de agravos à saúde, sendo uma modalidade milenar e bastante difundida ao longo das gerações. Com isso, pode ser aplicada em cuidados mais simples ou complexos, incluindo os cuidados paliativos com ação voltada ao alívio dos seus sintomas e na promoção de qualidade de vida dos pacientes. O objetivo do estudo foi buscar na literatura a aplicação da fitoterapia em pacientes em cuidados paliativos. Trata-se de uma revisão integrativa da literatura de caráter exploratório com abordagem qualitativa com dados coletados das bases eletrônicas SciELO (Scientific Electronic Library Online), BVS (Biblioteca Virtual em Saúde) e PubMed (U.S. National Library of Medicine), durante o período de 2019 a 2024, obtidos entre maio e junho de 2024. Os resultados encontraram 73 artigos que após revisão criteriosa foram excluídos 63, selecionando ao final 10 artigos que demonstram a utilização da fitoterapia em cuidados paliativos, fornecendo benéficos com ação analgésica, antitumoral, anti-inflamatória, antioxidante e na caquexia, além dos seus principais sintomas (dor, fadiga, ansiedade, depressão, entre outros) que podem ser tratados com fitoterápicos e aponta os desafios para o uso e prescrição adequada, conhecimento científico insuficiente dos profissionais de saúde sobre essa terapia e a necessidade de desenvolvimento de novos estudos nesse campo de pesquisa. Conclui-se que a aplicação da fitoterapia em cuidados paliativos demonstra-se significativa e viável para o alívio e para o aumento da sobrevida, de forma que melhore sua qualidade de vida e mantenha a autonomia desses pacientes. Ainda assim, existem barreiras que tanto os profissionais quanto os usuários de saúde precisam superar, com a atuação do enfermeiro na criação de vínculo entre as duas partes e com a educação permanente em saúde e com o incentivo para o desenvolvimento de novas pesquisas nessa área.
PENINGKATAN EFISIENSI INHIBISI EKSTRAK KULIT BUAH PISANG KEPOK (MUSA PARADISIACA F) SEBAGAI GREEN CORROSION INHIBITOR MENGGUNAKAN PELARUT POLAR
Authors: Simamora Lorenz Octavia , Suharti Profiyanti Hermien 
Published: September 2024

Salah satu jenis tumbuhan yang dapat dikembangkan pemanfaatannya sebagai Green Corrosion Inhibitor adalah kulit buah pisang kepok (Musa paradisiaca F). Kulit buah pisang kepok dapat dijadikan sebagai Green Corrosion Inhibitor (GCI) karena mengandung antioksidan tanin yang dapat menghambat laju korosi. Pengolahan kulit buah pisang kepok menjadi GCI dapat dilakukan dengan beberapa metode ekstraksi, yaitu ekstraksi maserasi, ekstraksi soxhlet, dan UAE (Ultrasonic Assisted Extraction) dengan menggunakan pelarut polar yaitu aseton. Penelitian ini bertujuan untuk mengetahui pengaruh metode ekstraksi dan pengaruh massa kulit buah pisang kepok (Musa paradisiaca F) yang menghasilkan kadar tanin terbaik untuk digunakan sebagai GCI. Uji kuantitatif kadar tanin hasil ekstrak dilakukan menggunakan Spektrofotometer UV-Vis pada masing-masing sampel yang telah diekstraksi. Setelah itu, semua sampel akan melalui proses distilasi untuk menghilangkan kandungan pelarut polar yang sebelumnya didapatkan dari beberapa proses metode ekstraksi. Tahap berikutnya adalah uji korosi larutan hasil ekstraksi pada lempengan baja karbon berukuran 2 x 3 x 1 cm menggunakan larutan NaCl selama 24 jam dalam waktu 14 hari. Kehilangan berat (weight loss) pada masing-masing lempengan baja karbon digunakan untuk menentukan efisiensi inhibisi pada masing-masing sampel. Hasil penelitian terbaik diperoleh dari metode ekstraksi soxhlet dengan variabel massa 20 gram yang menghasilkan kadar tanin sebesar 181,70 ppm dan menghasilkan efisiensi inhibisi tertinggi sebesar 30,68%.
Kata kunci: aseton, tanin, ekstraksi maserasi, ekstraksi soxhlet, ultrasonic assisted extraction (UAE)
ANALISIS EKONOMI PRA RANCANGAN PABRIK KIMIA PEMBUATAN MINYAK ESTER DARI MINYAK KELAPA SAWIT BERKAPASITAS 4000 TON/TAHUN
Authors: Attaliya Yusica Radya , Sa'diyah Khalimatus 
Published: September 2024

Pendirian pabrik minyak ester berbahan baku minyak kelapa sawit memberikan dampak yang positif bagi pengguna mesin transformator baik di dalam maupun luar negeri. Berdirinya pabrik minyak ester yang direncanakan berlokasi di Kecamatan Jenu, Kabupaten Tuban, Jawa Timur dan memiliki 377 orang pekerja akan membuka peluang kerja baru bagi penduduk sekitar. Dari segi pembuatannya, minyak ester akan dihasilkan melalui proses transesterifikasi yang dinilai menghasilkan dengan konsentrasi lebih tinggi yaitu 97,69% dan waktu reaksi yang cepat yaitu 60 menit. Minyak ester dimanfaatkan oleh industri yang bergerak dibidang kosmetik, makanan, tekstil dan lainya, serta dapat digunakan menjadi bahan bakar pada mesin diesel dan pelumas. Analisis ekonomi pabrik minyak ester dilakukan dengan tujuan untuk mengetahui kelayakan berdirinya pabrik suatu pabrik. Analisis ekonomi dilakukan dengan menghitung analisis kelayakan dengan parameter seperti Total Capital Investment, Fixed Capital Investment, Working Capital Investmet, dan Total Production Cost serta analisis profitabilitas. Analisis kelayakan terdiri dari Total Capital Investment sebesar Rp 168.511.817.192,47; Fixed Capital Investment sebesar Rp 143.235.044.613,60; Working Capital Investmet sebesar Rp 25.276.772.578,87; Total Production Cost sebesar Rp 161.111.907.495,60. Analisis profitabilitas terdiri dari, nilai Return On Investment sebelum pajak sebesar 14% dan sesudah pajak sebesar 12%. Sedangkan nilai Minimum Pay Out Time sebelum pajak sebesar 3,85 tahun dan sesudah pajak sebesar 4,24 tahun. Break Event Point yang didapatkan 23,53% dan nilai Shut Down Point yang didapatkan sebesar 9%, sehingga diperoleh Internal Rate of Return sebesar 17%. Hasil analisis ekonomi menunjukkan kelayakan finansial pembangunan pabrik minyak ester dengan kapasitas 4000 ton/tahun.
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study
Authors: Li Yixuan , Wang Yahao , Xu Lili , Liu Chuanfeng , Cui Jiufa , Huang Yajing , Li Shufa , Wang Yangang , Dong Bingzi 
Published: September 2024

BackgroundGouty arthritis is a common inflammatory arthritis. The recurrent gout attacks severely damage the joint’s function, lead to bone erosion, and affect bone metabolism. The role of magnesium (Mg) ions in bone homeostasis has been recognized, whereas its specific relationship with gouty bone erosion remains unclear. This study examined the association between serum ionized Mg levels and bone erosion in patients with gout arthritis.MethodsA total of 769 patients with gout arthritis were included in the study. Participants were classified into four groups based on the quartiles of the serum ionized Mg level. Logistic regression analysis assessed the association between serum ionized Mg and bone erosion.ResultsCompared to patients without bone erosion, serum ionized Mg levels were lower in gout patients with bone erosion (p&lt;0.001). When dividing serum ionized Mg into quartiles, the prevalence rate of bone erosion in group Q1, representing the patients with the lowest serum ionized Mg levels, was notably higher than in Q2, Q3, and Q4 (60.2% vs. 43.6%, 45.6%, 40.3%, p&lt;0.001). Multiple logistic regression analysis revealed that patients in Q2-Q4 had a lower odds ratio (OR) of bone erosion compared to those in Q1 (ORs were 0.520, 0.533, and 0.411 in Q2-Q4, respectively, p&lt;0.001).ConclusionThe incidence of bone erosion is higher in gout arthritis patients with lower serum ionized Mg levels. High serum ionized Mg levels may be an independent protective factor for bone erosion in gout arthritis. Thus, Mg supplementation may be a promising approach to prevent or slow down the development of bone erosion in gouty arthritis.
Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018
Authors: Liu Weijie , Yang Xiulin , Zhan Ting , Huang Min , Tian Xiaorong , Tian Xia , Huang Xiaodong 
Published: September 2024

BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease. Body mass index (BMI) is the most used obesity index but has important limitations. The weight-adjusted waist index (WWI) is a novel obesity metric and accurately reflects body composition. We explored the association of WWI with all-cause and cardiovascular disease (CVD) mortality in MASLD.MethodsAdult participants with MASLD were included from NHANES 1999-2018. WWI was calculated by dividing the waist circumference (WC) by the square root of body weight. MASLD was diagnosed by the presence of hepatic steatosis and at least one cardiometabolic risk factor in the absence of other causes of steatosis. A fatty liver index ≥60 suggested the presence of hepatic steatosis. Mortality data was obtained by prospectively linking to the National Death Index. Multivariate Cox proportional hazards regression analyses were used to explore these associations and multiple adjustment models were constructed including crude, partial, and fully adjusted models.ResultsAfter adjusting for all covariates including BMI, WWI remained positively and linearly associated with all-cause and CVD mortality in MASLD (hazard ratios [HR] 1.247 and 1.218, respectively). Higher WWI was associated with a significantly increased risk of mortality (both p for trend &lt;0.05). There was an “obesity paradox” between BMI and all-cause mortality in MASLD, with significantly lower all-cause mortality in those with overweight/obesity compared to normal BMI (HR 0.625 and 0.596, respectively, p for trend = 0.024), and no association between BMI and CVD mortality. Interaction analyses indicated that these associations were influenced by several demographic variables and disease status. Time-dependent receiver operating characteristic curves indicated that the predictive value of WWI for mortality in MASLD was higher than that of BMI, WC, and waist-to-height ratio across all follow-up durations.ConclusionsWWI was positively and linearly associated with all-cause and CVD mortality in MASLD, whereas BMI did not accurately reflect mortality risk. WWI provided the optimal predictive value for mortality compared to traditional obesity indicators. These findings emphasize the potential use of WWI as a novel obesity indicator for mortality risk assessment, stratification, and prevention in MASLD.
Potential causal relationships between blood metabolites, inflammatory cytokines, and venous thromboembolism
Authors: Liu Qianying , Yang Fan , Kong Kangli , Lu Fangfang 
Published: September 2024

BackgroundVenous thromboembolism (VTE) is the abnormal coagulation of blood in deep veins, which impairs venous return and includes deep vein thrombosis (DVT) and pulmonary embolism (PE). The incidence of VTE is increasing, leading to severe complications and sequelae. Despite the widespread application of multi-omics analyses in vascular disease research, identifying the specific links between various metabolic products, cytokines, and VTE, as well as their potential mediating roles, requires further validation due to confounding factors.MethodsSummary statistics for 1,091 metabolites, 309 metabolite ratios (8,299 individuals), and 41 inflammatory cytokines (8,293 individuals) were obtained from the largest genome-wide association studies (GWAS). Summary statistics for VTE (21,021 cases, 391,160 controls), DVT (6,501 cases, 357,111 controls), and PE (10,046 cases, 401,128 controls) were derived from the FinnGen R10 dataset. We initially examined causal relationships using two-sample MR analysis, followed by Two-step Mendelian Randomization (TSMR) and Multivariable Mendelian Randomization (MVMR) to identify potential mediating mechanisms.ResultsWe identified causal associations for 78 blood metabolites with VTE, 79 with DVT, and 81 with PE. Among all 41 inflammatory cytokines included, only platelet-derived growth factor BB (PDGF-BB) levels showed a causal relationship with increased risks of VTE, DVT, and PE. MVMR analysis revealed that the associations between glycocholate levels and VTE, DVT, and PE were mediated by PDGF-BB, accounting for 14.54% (p=2.84E-04), 17.10% (p=3.64E-05), and 10.44% (p=1.39E-02), respectively. Furthermore, the associations between dodecanedioate (C12:1-DC) levels and VTE and DVT were also mediated by PDGF-BB, accounting for 12.79% (p=6.10E-04) and 12.17% (p=2.13E-04), respectively.ConclusionThis study reveals significant associations between specific blood metabolites and the risks of VTE, DVT, and PE, with some associations potentially mediated by PDGF-BB.
Clinical characteristics and visual outcomes of animal-induced ocular injuries: a prospective multicenter study in Iran
Authors: Mohammadi Mohammad , Attar Alireza , Mahmoudinezhad Golnoush , Shahesmaeilinejad Armita , Zhu Dagny , Fowler Brian , Farsi Yeganeh , Shirvani Mohammad , Gohari Mohsen 
Published: September 2024

BackgroundAnimal-induced ocular injuries represent an under-documented health problem that may pose significant visual complications. This study aimed to investigate the clinical characteristics and outcomes of ocular injuries caused by animals.MethodsThis multicenter prospective study enrolled patients with a history of animal-induced ocular injuries presenting to the ophthalmology departments of two tertiary hospitals over a one-year period. All participants underwent comprehensive assessments by ophthalmologists, and the following data were collected: demographic information, animal species involved, injury details, pre- and post-treatment visual data, management strategies, and follow-up outcomes.ResultsSeventy-two patients (62.5% male) were included in the study. Insects were the most common species, causing 37.5% of ocular injuries. The type of animal involved was significantly associated with injury patterns (p &lt; 0.0001), visual impairments at presentation (p &lt; 0.05), and need for surgery (p &lt; 0.001). Insects predominantly caused periorbital soft tissue injuries; birds primarily affected the anterior segment; dogs and cats mainly led to adnexal injuries; and equines often involved both anterior and posterior segments. Equine-related injuries resulted in the most severe visual impairments, requiring surgical interventions in all cases. At the same time, the majority of cases involved with other animal species experienced no visual impairment. The number of patients without visual impairment increased from 46 cases (63.9%) at the time of presentation to 58 (80.6%) at discharge after treatment. At follow-up, eight patients (11.1%) experienced complications, including traumatic cataract (n = 6, 8.3%), endophthalmitis (n = 3, 4.2%), corneal scarring (n = 1, 1.4%), and retinal detachment (n = 1, 1.4%). Rooster pecking was the leading cause of complications, including endophthalmitis and traumatic cataract.ConclusionThis study revealed that depending on the type of animal causing the injury, animal-induced ocular injuries present with diverse characteristics, requiring appropriate treatment approaches and potentially resulting in different outcomes. These findings may promote public awareness and improve preventive strategies and clinical guidelines development.
The use of plasma exchange with albumin replacement in the management of Alzheimer’s disease: a scoping review
Authors: Cantero-Fortiz Yahveth , Boada Mercè 
Published: September 2024

IntroductionAD is a progressive neurodegenerative disorder causing significant cognitive decline and impaired daily functioning. Current treatments offer only modest relief, and many amyloid-targeting therapies have failed, prompting exploration of alternative approaches such as PE with albumin replacement.ObjectivesThis scoping review systematically maps the literature on PE with albumin replacement in AD management, focusing on outcomes, methodologies, and reported benefits and risks.MethodsA comprehensive search in PubMed, supplemented by reference scanning and hand-searching, identified studies involving PE with albumin replacement in AD patients. Data charting and critical appraisal were conducted using standardized tools.ResultsSeven primary studies from the AMBAR (Alzheimer Management by Albumin Replacement) trial met the inclusion criteria, consistently reporting improvements in cognitive function, positive neuroimaging results, and favorable neuropsychiatric outcomes. For instance, one study found a significant slowing of cognitive decline (p &lt; 0.05) among patients receiving PE with albumin replacement. Another study showed better preservation of hippocampal volume and improved brain perfusion metrics in the treatment group (p &lt; 0.05). The intervention was generally well-tolerated with manageable side effects.ConclusionPE with albumin replacement is a promising therapeutic approach for AD, warranting further investigation to confirm its efficacy and safety across broader settings.Scoping review registrationhttps://osf.io/v6dez/?view_only=1cd9637e7e0347d39713bf19aac0dfe8.
Predicting the risk of colorectal cancer among diabetes patients using a random survival forest-guided approach
Authors: Yau Sarah Tsz Yui , Hung Chi Tim , Leung Eman Yee Man , Chong Ka Chun , Lee Albert , Yeoh Eng Kiong 
Published: September 2024

BackgroundColorectal cancer (CRC) is the third most frequently diagnosed cancer worldwide. Diabetes and CRC share many overlapping lifestyle risk factors such as obesity, heavy alcohol use, and diet. This study aims to develop a risk scoring system for CRC prediction among diabetes patients using routine medical records.MethodsA retrospective cohort study was conducted using electronic health records of Hong Kong. Patients who received diabetes care in public general outpatient clinics between 2010 and 2019 and had no cancer history were identified, and followed up until December 2019. The outcome was diagnosis of CRC during follow-up. For model building, predictors were first selected using random survival forest, and weights were subsequently assigned to selected predictors using Cox regression.ResultsOf the 386,325 patients identified, 4,199 patients developed CRC during a median follow-up of 6.2 years. The overall incidence rate of CRC was 1.93 per 1000 person-years. In the final scoring system, age, waist-to-hip ratio, and serum creatinine were included as predictors. The C-index on test set was 0.651 (95%CI: 0.631-0.669). Elevated serum creatinine (≥127 µmol/L) could be a potential important predictor of increased CRC risk.ConclusionWhile obesity is a well-known risk factor for CRC, renal dysfunction could be potentially linked to an elevated risk of CRC among diabetes patients. Further studies are warranted to explore whether renal function could be a potential parameter to guide screening recommendation for diabetes patients.