bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Often are Pediatric Patients with Clinically Amyopathic Dermatomyositis Truly Amyopathic?
Authors: Oberle Edward J. , Bayer Michelle L. , Chiu Yvonne E. , Co Dominic O. 
Published: November 2016

AbstractBackgroundPediatric patients can present with skin manifestations of dermatomyositis without overt weakness (clinically amyopathic juvenile dermatomyositis [JDM]), but it is unclear how often this happens and how often they have subclinical muscle inflammation.ObjectiveOur goal was to determine the frequency of clinically amyopathic JDM and the frequency with which a thorough evaluation uncovers subclinical myositis at a single institution.MethodsA retrospective review was performed of 46 patients diagnosed with JDM at Children's Hospital of Wisconsin.ResultsOf 46 patients presenting with skin findings consistent with dermatomyositis, 10 patients (21.7%) did not have evidence of muscle involvement on history or exam, and these tended to be the younger patients. Of these 10, only 2 (4% of all the JDM patients) were truly amyopathic upon further evaluation (all five muscle enzymes [aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, creatine kinase and aldolase], magnetic resonance imaging [MRI], muscle biopsy). In our series, muscle biopsy was not helpful in identifying subclinical myositis. In contrast, MRI did uncover subclinical muscle disease.ConclusionThese data suggest that truly amyopathic JDM is rare and that a thorough workup that includes all five muscle enzymes and MRI may uncover occult myositis.
Help yourself by helping others: The joint impact of group member organizational citizenship behaviors and group cohesiveness on group member objective task performance change
Authors: Liu Dong , Chen Xiao‐Ping , Holley Erica 
Published: November 2016

AbstractThis paper examines how a group member's individual‐targeted citizenship behavior (OCBI) and organization‐targeted citizenship behavior (OCBO) interact with a salient group‐level contextual variable, group cohesiveness, to foster positive change for that group member, starting with job self‐efficacy change, and followed by objective task performance change. Over a span of 6 months, we engaged in multilevel, multisource, multistage data collection and surveyed 587 members in 83 work groups. Our results indicate that a group member's OCBI, in comparison with OCBO, is more positively related to his or her job self‐efficacy change. Group cohesiveness was found to attenuate the relationship between a group member's OCBI and job self‐efficacy change, and conversely, to accentuate the relationship between a group member's OCBO and job self‐efficacy change. Furthermore, a group member's job self‐efficacy change mediated the interactive effects of the group member's OCBI and group cohesiveness (as well as the group member's OCBO and group cohesiveness) on his or her objective task performance change.
Trace Class Markov Chains for Bayesian Inference with Generalized Double Pareto Shrinkage Priors
Authors: Pal Subahdip , Khare Kshitij , Hobert James P. 
Published: November 2016

AbstractBayesian shrinkage methods have generated a lot of interest in recent years, especially in the context of high‐dimensional linear regression. In recent work, a Bayesian shrinkage approach using generalized double Pareto priors has been proposed. Several useful properties of this approach, including the derivation of a tractable three‐block Gibbs sampler to sample from the resulting posterior density, have been established. We show that the Markov operator corresponding to this three‐block Gibbs sampler is not Hilbert–Schmidt. We propose a simpler two‐block Gibbs sampler and show that the corresponding Markov operator is trace class (and hence Hilbert–Schmidt). Establishing the trace class property for the proposed two‐block Gibbs sampler has several useful consequences. Firstly, it implies that the corresponding Markov chain is geometrically ergodic, thereby implying the existence of a Markov chain central limit theorem, which in turn enables computation of asymptotic standard errors for Markov chain‐based estimates of posterior quantities. Secondly, because the proposed Gibbs sampler uses two blocks, standard recipes in the literature can be used to construct a sandwich Markov chain (by inserting an appropriate extra step) to gain further efficiency and to achieve faster convergence. The trace class property for the two‐block sampler implies that the corresponding sandwich Markov chain is also trace class and thereby geometrically ergodic. Finally, it also guarantees that all eigenvalues of the sandwich chain are dominated by the corresponding eigenvalues of the Gibbs sampling chain (with at least one strict domination). Our results demonstrate that a minor change in the structure of a Markov chain can lead to fundamental changes in its theoretical properties. We illustrate the improvement in efficiency resulting from our proposed Markov chains using simulated and real examples.
Characterization of a PCR‐based lymphocyte clonality assay as a complementary tool for the diagnosis of feline lymphoma
Authors: Hammer S. E. , Groiss S. , Fuchs‐Baumgartinger A. , Nedorost N. , Gress V. , Luckschander‐Zeller N. , Saalmüller A. , Schwendenwein I. , Rütgen B. C. 
Published: November 2016

AbstractDifferentiation between resident mature lymphocyte populations and small cell lymphoma cannot be made by cytological review alone and remains challenging in histopathological review. These cases warrant application of complementary tools like PCR‐based immunoglobulin (IG) and T‐cell receptor (TCR) clonality testing for confirmation. In this prospective study, diagnostic sensitivity and specificity of different primer sets for routine diagnosis of feline TCR gamma (TCRG) and complete IG heavy chain (IGH) gene rearrangements were assessed. Fine needle aspirates from 20 feline lymphoma cases and lymph node material from 10 cats without hematopoietic neoplasia were subjected to clonality testing. Feline lymphoma cell lines and previously confirmed patient material served as positive control. Detection limits for clonal populations within a polyclonal background was 90% for B‐cells and 50% for T‐cells. Diagnostic sensitivity and specificity of the clonality assay were 70% and 90%. Overall diagnostic accuracy was 77%, positive predictive value 93% and negative predictive value 60%.
From weed biology to successful control: an example of successful management of Ludwigia grandiflora in Germany
Authors: Hussner A , Windhaus M , Starfinger U 
Published: November 2016

SummaryLudwigia grandiflora (water primrose), a native to the Americas, is one of the most important invasive alien aquatic plants in Europe. In Germany, a first population was found in an oxbow lake of the River Leda in Lower Saxony, north‐western Germany, in 2004. Ludwigia grandiflora formed both dense monospecific patches and mixed stands with native plants. A study on the biology of L. grandiflora documented that the plants regrow in spring from vegetative means only, even though viable seed production occurred. Hand weeding was successfully tested in different sampling sites as a sustainable management tool and subsequently used for the management of this species. Within 3 days, more than 99% of the biomass (25 tonnes of fresh mass) was harvested in 2013. Afterwards, a one‐day post‐treatment in the same year, two‐one‐day treatments in 2014 and one‐one‐day treatment in 2015 were made to harvest the regrown plants. After the first year, plant regrowth occurred only in one extremely muddy site, while in more than 99% of the water body, L. grandiflora was eradicated. Even though L. grandiflora was not completely eradicated from the water, a total eradication seems achievable within the next few years. The study documented the difficulties in the management of aquatic weeds, particularly in heterogeneous habitats with varying sediment structure. Management measures must be adapted to the infested habitat and species biology, which is mandatory for successful management of all aquatic weeds.
Genome Sequences of Eight Bacterial Species Found in Coculture with the HaptophyteChrysochromulina tobin
Authors: Fixen Kathryn R. , Starkenburg Shawn R. , Hovde Blake T. , Johnson Shannon L. , Deodato Chloe R. , Daligault Hajnalka E. , Davenport Karen W. , Harwood Caroline S. , Cattolico Rose Ann 
Published: November 2016

ABSTRACTThe microalgal division Haptophyta uses a range of nutritional sourcing, including mixotrophy. The genome of a member of this taxon,Chrysochromulina tobin, suggests that interactions with its bacterial cohort are critical forC. tobinphysiology. Here, we report the genomes of eight bacterial species in coculture withC. tobin.
Genome Sequence of Clostridium paraputrificum 373-A1 Isolated in Chile from a Patient Infected with Clostridium difficile
Authors: Guerrero-Araya Enzo , Plaza-Garrido Angela , Díaz-Yañez Fernando , Pizaro-Guajardo Marjorie , Valenzuela Sandro L. , Meneses Claudio , Gil Fernando , Castro-Nallar Eduardo , Paredes-Sabja Daniel 
Published: November 2016

ABSTRACT

Clostridium paraputrificum
is a gut microbiota member reported in several cases of bacteremia and coinfections. So far, only one genome sequence of a
C. paraputrificum
(AGR2156) isolate is available. Here, we present the draft genome of
C. paraputrificum
strain 373-A1, isolated from stools from a patient with
C. difficile
infection.
Complete, Closed Genome Sequences of 10 Salmonella enterica subsp.
enterica
Serovar Typhimurium Strains Isolated from Human and Bovine Sources
Authors: Nguyen Scott V. , Harhay Dayna M. , Bono James L. , Smith Timothy P. L. , Fields Patricia I. , Dinsmore Blake A. , Santovenia Monica , Kelley Christy M. , Wang Rong , Bosilevac Joseph M. , Harhay Gregory P. 
Published: November 2016

ABSTRACT

Salmonella enterica
is a leading cause of enterocolitis for humans and animals.
S. enterica
subsp.
enterica
serovar Typhimurium infects a broad range of hosts. To facilitate genomic comparisons among isolates from different sources, we present the complete genome sequences of 10
S
. Typhimurium strains, 5 each isolated from human and bovine sources.
Complete Whole-Genome Sequence of Salmonella enterica subsp.
enterica
Serovar Java NCTC5706
Authors: Fazal Mohammed-Abbas , Alexander Sarah , Burnett Edward , Deheer-Graham Ana , Oliver Karen , Holroyd Nancy , Parkhill Julian , Russell Julie E. 
Published: November 2016

ABSTRACT

Salmonellae are a significant cause of morbidity and mortality globally. Here, we report the first complete genome sequence for
Salmonella enterica
subsp.
enterica
serovar Java strain NCTC5706. This strain is of historical significance, having been isolated in the pre-antibiotic era and was deposited into the National Collection of Type Cultures in 1939.
Draft Genome Sequence of a Novel
Luteimonas
sp. Strain from Coral Mucus, Hawai‘i
Authors: Wan Xuehua , Miller James M. , Rowley Sonia J. , Hou Shaobin , Donachie Stuart P. 
Published: November 2016

ABSTRACT

Luteimonas
sp. strain JM171 was cultivated from mucus collected around the coral
Porites lobata
. The JM171 draft genome of 2,992,353 bp contains 2,672 protein-coding open reading frames, 45 tRNA coding regions, and encodes a putative globin-coupled diguanylate cyclase,
Jm
GReg.
Draft Genome Sequences of Lactobacillus animalis Strain P38 and Lactobacillus reuteri Strain P43 Isolated from Chicken Cecum
Authors: Rezvani Morvarid , Mendoza Mary , Koci Matthew D. , Daron Caitlyn , Levy Josh , Hassan Hosni M. 
Published: November 2016

ABSTRACT

Here, we present the genome sequence of
Lactobacillus animalis
strain P38 and
Lactobacillus reuteri
strain P43, both isolated from the cecum content of a 4-week old chicken fed a diet supplemented with the prebiotic β(1-4)galacto-oligosaccharide (GOS). These indigenous
Lactobacillus
isolates are potential probiotic organisms for poultry.
Draft Genome Sequence of the Oleaginous Yeast
Cryptococcus curvatus
ATCC 20509
Authors: Close Dan , Ojumu John 
Published: November 2016

ABSTRACT

Cryptococcus curvatus
ATCC 20509 is a commonly used nonmodel oleaginous yeast capable of converting a variety of carbon sources into fatty acids. Here, we present the draft genome sequence of this popular organism to provide a means for more in-depth studies of its fatty acid production potential.
Draft Genome Sequence of
Cryptococcus terricola
JCM 24523, an Oleaginous Yeast Capable of Expressing Exogenous DNA
Authors: Close Dan , Ojumu John , Zhang Gui 
Published: November 2016

ABSTRACT

Cryptococcus terricola
JCM 24523 has recently been identified as an oleaginous yeast capable of converting starch into fatty acids. This draft genome sequence provides a platform for elucidating its fatty acid production potential and supporting comparisons with other oleaginous species.
Complete Genome Sequence of the Neonatal Meningitis-Causing Escherichia coli Strain NMEC O18
Authors: Nicholson Bryon A. , Wannemuehler Yvonne M. , Logue Catherine M. , Li Ganwu , Nolan Lisa K. 
Published: November 2016

ABSTRACT

Neonatal meningitis
Escherichia coli
(NMEC) is a common agent of neonatal bacterial meningitis, causing high neonatal mortality and neurologic sequelae in its victims. Here, we present the complete genome sequence of NMEC O18 (also known as NMEC 58), a highly virulent (O18ac:K1, ST416) strain.
Contrasting geochemical signatures of fluid-absent versus fluid-fluxed melting of muscovite in metasedimentary sources: The Himalayan leucogranites
Authors: Gao Li-E. , Zeng Lingsen , Asimow Paul D. 
Published: November 2016

Abstract
Most of the Himalayan Cenozoic leucogranites are products of partial melting of metapelite sources. In the Malashan-Gyirong area (southern Tibet), the geochemical compositions of leucogranites define two groups with distinct whole-rock major elements, large ion lithophile elements, rare earth elements, high field strength elements, and Sr and Hf isotope ratios. Based on published experimental results that define generalized melting reactions of metapelitic sources, we infer that these leucogranites are the products of two different types of crustal anatexis: fluid-fluxed melting and fluid-absent melting of muscovite in metasedimentary sources. As compared to the leucogranites derived from fluid-absent melting, those from fluid-fluxed melting have relatively higher Ca, Sr, Ba, Zr, Hf, Th, and light rare earth element concentrations, and Zr/Hf, Eu/Eu*, and Nd/Nd*, but lower Rb, Nb, Ta, and U concentrations, Rb/Sr and 87Sr/86Sr ratios, and εHf(t). The geochemical differences can be explained by melting behaviors of major (muscovite, feldspar) and accessory minerals (zircon and monazite) during different modes of crustal anatexis. The systematic elemental and isotopic signatures of different types of crustal anatexis and, in particular, the coupling of major and trace elements that results from common influences on rock-forming and accessory mineral behaviors provide tools with which to refine our understanding of the nature of crustal anatexis.
Demise of Ediacaran dolomitic seas marks widespread biomineralization on the Siberian Platform
Authors: Wood R.A. , Zhuravlev A.Yu. , Sukhov S.S. , Zhu M. , Zhao F. 
Published: November 2016

Abstract
The trigger for biomineralization of metazoans in the terminal Ediacaran, ca. 550 Ma, has been suggested to be the rise of oxygenation or an increase in seawater Ca concentration, but geochemical and fossil data have not been fully integrated to demonstrate cause and effect. Here we combine the record of macrofossils with early marine carbonate cement distribution within a relative depth framework for terminal Ediacaran to Cambrian successions on the eastern Siberian Platform, Russia, to interrogate the evolution of seawater chemistry and biotic response. Prior to ca. 545 Ma, the presence of early marine ferroan dolomite cement suggests dominantly ferruginous anoxic “aragonite-dolomite seas”, with a very shallow oxic chemocline that supported mainly soft-bodied macrobiota. After ca. 545 Ma, marine cements changed to aragonite and/or high-Mg calcite, and this coincides with the appearance of widespread aragonite and high-Mg calcite skeletal metazoans, suggesting a profound change in seawater chemistry to “aragonite seas” with a deeper chemocline. By early Cambrian Stage 3, the first marine low-Mg calcite cements appear, coincident with the first low-Mg calcite metazoan skeletons, suggesting a further shift to “calcite seas”. We suggest that this evolution of seawater chemistry was caused by enhanced continental denudation that increased the input of Ca into oceans so progressively lowering Mg/Ca, which, combined with more widespread oxic conditions, facilitated the rise of skeletal animals and in turn influenced the evolution of skeletal mineralogy.
Health-related quality of life after pulmonary embolism: a cross-sectional study
Authors: Tavoly Mazdak , Utne Kristin Kornelia , Jelsness-Jørgensen Lars-Petter , Wik Hilde Skuterud , Klok Frederikus A , Sandset Per Morten , Ghanima Waleed 
Published: November 2016

ObjectivesThe psychological effects of acute pulmonary embolism (PE) have scarcely been studied. The aims of this study were to evaluate health-related quality of life (HRQoL) in patients with a history of PE compared with that of the general population and buddy controls, and to explore factors that may predict impaired HRQoL.DesignCross-sectional.SettingHaematology and thrombosis unit in Fredrikstad, Norway.Participants213 consecutive patients treated for PE were identified from hospital registries. Eligible patients were scheduled for a single study visit, including a functional capacity test (6 min walking test). HRQoL was assessed using the EuroQol 5D dimensions 3-level (EQ-5D-3L) questionnaire, of which the results were compared with Danish population norms and age-matched and sex-matched buddy controls. The buddy controls were recruited by asking every patient to hand over the EQ-5D questionnaire to 2 age-matched and sex-matched friends or relatives. Multivariable regression analyses were used to examine possible determinants of reduced HRQoL.ResultsMean age was 61 years (SD 15), 117 (55%) were males, and median time since diagnosis was 3.8 years (range 0.3–9.5). Mean EuroQol visual analogue scale (EQ VAS) was 67 in PE as compared with 81 in the general population (p<0.005) and corresponding EQ-5D index values were 0.80 and 0.86 (p<0.005). Patients reported more problems in all 5 EQ-5D compared with both the buddy controls and the general population, p<0.05. Shorter 6 min walking distance (β=0.09, p<0.005) and patient-reported dyspnoea (β=11.27, p<0.005) were independent predictors of lower EQ VAS scores.ConclusionsOur findings show that patients with a history of PE have impaired HRQoL when compared with the general population and buddy controls. Reduced functional capacity and persistent dyspnoea were the main predictors of this impairment.
Endoscopic resection of high-risk T1 colorectal carcinoma prior to surgical resection has no adverse effect on long-term outcomes
Authors: Overwater A , Kessels K , Elias S G , Backes Y , Spanier B W M , Seerden T C J , Pullens H J M , de Vos tot Nederveen Cappel W H , van den Blink A , Offerhaus G J A , van Bergeijk J , Kerkhof M , Geesing J M J , Groen J N , van Lelyveld N , ter Borg F , Wolfhagen F , Siersema P D , Lacle M M , Moons L M G 
Published: November 2016

ObjectiveIt is difficult to predict the presence of histological risk factors for lymph node metastasis (LNM) before endoscopic treatment of T1 colorectal cancer (CRC). Therefore, endoscopic therapy is propagated to obtain adequate histological staging. We examined whether secondary surgery following endoscopic resection of high-risk T1 CRC does not have a negative effect on patients' outcomes compared with primary surgery.DesignPatients with T1 CRC with one or more histological risk factors for LNM (high risk) and treated with primary or secondary surgery between 2000 and 2014 in 13 hospitals were identified in the Netherlands Cancer Registry. Additional data were collected from hospital records, endoscopy, radiology and pathology reports. A propensity score analysis was performed using inverse probability weighting (IPW) to correct for confounding by indication.Results602 patients were eligible for analysis (263 primary; 339 secondary surgery). Overall, 34 recurrences were observed (5.6%). After adjusting with IPW, no differences were observed between primary and secondary surgery for the presence of LNM (OR 0.97; 95% CI 0.49 to 1.93; p=0.940) and recurrence during follow-up (HR 0.97; 95% CI 0.41 to 2.34; p=0.954). Further adjusting for lymphovascular invasion, depth of invasion and number of retrieved lymph nodes did not alter this outcome.ConclusionsOur data do not support an increased risk of LNM or recurrence after secondary surgery compared with primary surgery. Therefore, an attempt for an en-bloc resection of a possible T1 CRC without evident signs of deep invasion seems justified in order to prevent surgery of low-risk T1 CRC in a significant proportion of patients.
Efficacy and tolerability of repository corticotropin injection in patients with persistently active SLE: results of a phase 4, randomised, controlled pilot study
Authors: Furie Richard , Mitrane Margaret , Zhao Enxu , Das Maya , Li Daner , Becker Patrice M 
Published: November 2016

ObjectiveTo evaluate the efficacy of a prolonged-release formulation of a porcine adrenocorticotropic hormone analogue (repository corticotropin injection (RCI)) added to standard of care in patients requiring moderate-dose corticosteroids for symptomatic SLE.MethodsThis prospective, randomised, double-blind, phase 4, pilot study (NCT01753401) enrolled 38 patients with persistently active SLE involving skin and/or joints. Enrolled patients received RCI, 40 U daily or 80 U every other day, or volume-matched placebo gel, for 8 weeks, with dose tapering to twice weekly during weeks 5–8. Efficacy endpoints included proportion of responders at week 4 based on a novel composite measure that included resolution of rash or arthritis measured using the hybrid SLE Disease Activity Index (hSLEDAI) without worsening British Isles Lupus Assessment Group (BILAG) scores in other organ systems at week 4 (primary), as well as improvements in total hSLEDAI and BILAG scores and other measures of skin and joint disease activity over the 8-week treatment period.ResultsResponse, as defined for the primary endpoint, did not differ significantly between the combined placebo and RCI-treated groups at week 4. At week 8, the proportion of responders was higher in RCI-treated patients but did not statistically differ between groups (RCI 40 U (53.8%), RCI 80 U (33.3%), combined placebo (27.3%)). However, RCI treatment was associated with statistically significant improvements in several secondary endpoints, including total hSLEDAI, total BILAG and Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity scores within 8 weeks. Treatment was well tolerated.ConclusionsAlthough the primary endpoint was not met in this pilot study, secondary and post hoc analyses suggested that RCI was associated with improvements in SLE disease activity in a select patient population with steroid-dependent persistent disease.Trial registration numberNCT01753401; results.