bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explanatory and Confirmatory Factor Structure of Beck Scale for Suicide Ideation in Non-clinical Sample
Authors: Alsalman R. , Alansari B. 
Published: June 2017

IntroductionThe Beck Scale for Suicidal Ideation (BSS) is a self-report 19-item scale preceded by five screening items. The BSS and its screening items are intended to assess a patient's thoughts, plans and intent to commit suicide. All 24 items are rated on a three-point scale (0 to 2). In this study, scores from the five screening items were included in the overall score. Therefore, total scores could range from 0 to 48.There is no study until this date that examines the factor structure of BSS among Kuwaitis.ObjectivesThe current study investigated the original three-factor model of the (BSS) in non-clinical sample.MethodsSample one consisted of 285 males and 300 female students from Kuwait University while sample two consisted of 201 males and 302 females from Kuwait University. The Arabic version of BSS was administered to participants. Explanatory factor based on sample 1 and conformity factor analysis based on sample 2 of BSS were used in this study.ResultsThe explanatory and confirmatory factor analysis of (BSS) extracts three factors and three structures of BSS. Factor I = active suicidal desire; Factor II = preparation; Factor III = passive suicidal desire. In addition, the results revealed no significant gender differences in the factor structure of BSS.ConclusionsThe results of both confirmatory and exploratory factor analysis indicated that the original three-factor model provided the best fit for the two genders.
Mood Disorders in Elderly Patients Hospitalized for Acute Exacerbation of COPD
Authors: Bonfitto I. , Moniello G. , Pascucci M. , Bellomo A. 
Published: June 2017

IntroductionChronic obstructive pulmonary disease (COPD) represents the most common cause of chronic respiratory failure and it's associated with several comorbidities such as depression. Depression is about four times more frequent in elderly patients with COPD compared to peers who are not affected and its prevalence increases with the degree of disease severity.ObjectiveTo assess mood and perception of the quality of life in elderly patients hospitalized for acute exacerbation of COPD.MethodsThirty-five elderly patients hospitalized for reactivation of COPD were examined; they were subjected to spirometry test for the calculation of FEV1 and to COPD Assessment Test (CAT) and Hamilton Rating Scale for Depression (HAM-D) to evaluate impact of COPD on patients’ quality of life and depressive symptomatology, respectively. The number of COPD exacerbations in the last year prior to hospitalization and the number of recovery days required for the stabilization of patients were also recorded.ResultsThere were strongly significative correlations (P < 0.001), positive between HAM-D scores, CAT scores, number of exacerbation in the last year and hospital length of stay and negative between HAM-D scores and FEV1 values. Furthermore, females were more depressed, with lower FEV 1 (P = 0.043) and with a longer length of stay (P = 0.039) as compared to males.ConclusionsA greater severity of depressive symptoms is related to a greater severity of COPD exacerbations, disability associated with it and perceived by the patient, as well as a higher number of recovery days and annual acute exacerbations, particularly in female gender.
A Residential Psychiatric Approach for Forensic Patients: The Experience of “Tiziano” Facility
Authors: Cargioli C. , Polese L. , Macchia G. 
Published: June 2017

IntroductionItalian forensic mental hospitals closed on March 31st, 2014 and offenders sentenced to need a psychiatric care are restrained in facilities. Since 2002, the residential psychiatric facility “Tiziano” (Aulla, Massa-Carrara) hosts forensic patients, on appointment with national health system and compulsorily admitted by the justice system.MethodsThis descriptional and prospective study provides a thorough report on the main epidemiological, clinical, and criminological features of 60 mentally ill offenders hosted in the “Tiziano” facility between 2002 and June 2016.ResultsMost forensic patients were male (90%, n = 54; average age: 33 years). Sixty percent of subjects (n = 36) had a clinical diagnosis of psychosis (19.4% affective psychosis, 72.2% non-affective psychosis, 8.4% organic psychosis), and about one third of them (31.6%, n = 19) had a personality disorder (63.1%, n = 12, antisocial personality disorder, 42.1%, n = 8, borderline personality disorder, 21.0%, n = 4 other personality disorders). Mental insufficiency was diagnosed in 11.6% (n = 7) of subjects, while substance use disorder affected 35.0% (n = 21) and alcohol use disorder 26.6% (n = 16). Forty-nine patients (81.7%) had committed serious crimes against people; 15% (n = 9) were murderers or attempted murderers, and 46.7% (n = 28) had committed more crimes. The average length of stay is 22 months.ConclusionsTo date, there are no data about long-term follow-up and clinical outcome of mentally ill offenders restrained in Italian psychiatric facilities. Additional studies are needed to assess psychopathology and differentiate treatment according to diagnosis, and to identify risk factors of relapse for criminal behavior relapse.
Experiences of Young Offenders and Health-care Professionals Involved in Transitions from Forensic Adolescent Mental Health Services: A Qualitative Study
Authors: Livanou M. , Furtado V. , Singh S. 
Published: June 2017

IntroductionTransitions from child and adolescent mental health services to adult mental health services have been quite troublesome for young people in the UK. There is strong evidence throughout the literature that long waiting lists and rigid adult services criteria hamper dramatically transitions across services. Little knowledge exists about transitions from forensic adolescent services to adult services.ObjectivesTo interview health-care professionals and young offenders in transition of care from forensic child and adolescent mental health services in England.AimsThis study aimed to bridge the current literature gap in regards to transitions across forensic services and the complexities resulting from disruptive care.MethodsThis study adopted a prospective design to identify young offenders referred to adult services over a six-month period. We utilized semi-structured interviews. Health-care professionals were interviewed about their transition views and perspectives. Young offenders were followed-up within a month of their transition and were interviewed.ResultsThe numbers of transitions within forensic settings are much lower compared to those of general transitions across mental health services in England. Transition delays were a repetitive theme across interviews due to lack of bed availability, especially in medium secure hospitals, and poor multi-agency communication. Commissioning determines age boundaries along with transfer destination for each service.ConclusionsIneffective liaison among different sectors might impact adversely young people and hallmark their long-stay in the system. Therefore, continuity of care within forensic services should be looked warily along with the role of policy shaped by commissioning. Multiple transitions can repeatedly traumatize young people moving across services.
Antidepressant use During Pregnancy and the Risk of Major Congenital Malformations in a Cohort of Depressed Pregnant Women: A Re-analysis of the Quebec Pregnancy Cohort
Authors: Bérard A. , Zhao J.P. , Sheehy O. 
Published: June 2017

ObjectiveTo quantify the association between first-trimester antidepressant exposure and the risk of major congenital malformations (MCM) in a cohort of depressed women.MethodData were obtained from the Quebec pregnancy cohort. All pregnancies with a diagnosis of depression or anxiety, or exposed to antidepressants in the 12 months before pregnancy, and ending with a live-born singleton were included. Antidepressant classes (selective serotonin reuptake inhibitors (SSRI), serotonin norepinephrine reuptake inhibitors (SNRI), tricyclic antidepressants (TCA), and other antidepressants), and types were individually compared to non-exposure during the first-trimester (depressed untreated). MCM overall and organ-specific malformations in the first year of life were identified.ResultEighteen thousand four hundred and eighty-seven depressed pregnant women were included. Citalopram use during the first-trimester was increasing the risk of MCM (aOR 1.36, 95%CI 1.08, 1.73; 88 exposed cases). Antidepressants with serotonin reuptake inhibition effect (SSRI, SNRI, amitriptyline (the most used TCA)) were increasing the risk of certain organ specific defects: paroxetine was increasing the risk of cardiac defects (aOR 1.45, 95%CI 1.12, 1.88), and ventricular/atrial septal defects (aOR 1.39, 95%CI 1.00. 1.93); citalopram was increasing the risk of musculoskeletal defects (aOR 1.92, 95%CI 1.40. 2.62), and cranyosynostosis (aOR 3.95, 95%CI 2.08, 7.52); TCA was associated with eye, ear, face and neck defects (aOR 2.45, 95%CI 1.05, 5.72), and digestive defects (aOR 2.55, 95%CI 1.40. 4.66); and venlafaxine was associated with respiratory defects (aOR 2.17, 95%CI 1.07, 4.38).ConclusionAntidepressants with effects on serotonin reuptake during embryogenesis are increasing the risk of some organ specific malformations in a cohort of pregnant women with depression.Disclosure of interestCOI: Disclosures and acknowledgments: AB is a consultant for plaintiffs in litigations involving antidepressants and birth defects. All other authors report no financial relationships with commercial interests. All authors have completed the ICMJE uniform disclosure form.
Predictors of the use of Psychosocial Interventions in Portugal: Results from the SMAILE Project
Authors: Cardoso G. , Antunes A. , Loureiro A. , Santana P. , Caldas-de-Almeida J. , Silva M. 
Published: June 2017

IntroductionThe treatment of psychiatric disorders depends on a combination of different types of care, such as psychiatric treatment and psychosocial interventions. However, there is little research on the factors that determine access to care, particularly to psychosocial interventions.ObjectivesTo characterize the use of psychosocial interventions (psychotherapy, day hospital, and psychosocial rehabilitation) in users of outpatient psychiatric services in Portugal.AimsThis retrospective study analyses all outpatient psychiatric visits in four Portuguese departments of psychiatry in the metropolitan areas of Lisbon and Porto, and aims to evaluate the socio-demographic and clinical determinants of psychosocial interventions.MethodsSocio-demographic and clinical variables were obtained from clinical charts of outpatients’ visits in 2002, 2007 and 2012 (n = 2621). All patients were characterized regarding the use of any psychosocial intervention beyond psychiatric consultations. Logistic regression analysis was performed to evaluate the predictors of psychosocial interventions use.ResultsBeing followed in 2012, being single, having no professional activity, and having a diagnosis of psychosis or common mental disorder were significantly associated (P < 0.05) with higher odds of accessing psychosocial interventions. On the other hand, a lower level of education was associated with less use of this type of care.ConclusionsSocio-demographic and clinical characteristics of psychiatric services, outpatients are determinants of the use of psychosocial interventions. Evidence suggests that social inequalities may influence the access to psychosocial interventions in Portugal.FundingFundação para a Ciência e Tecnologia (FCT), Portugal.
Effectiveness of Antipsychotic Medication in the Treatment of BPD
Authors: Stoffers-Winterling J. , Storebø O.J. , Völlm B. , Mattivi J. , Nielsen S. , Kielsholm M.L. , Simonsen E. , Lieb K. 
Published: June 2017

IntroductionThough prescription is off-lable, “atypical” or “second-generation” antipsychotics (SGAs) are prevalently given to borderline personality disorder (BPD) patients. They have also been the focus of research on pharmacological agents in BPD in recent years, as the previous version of the relating cochrane systematic review shows.ObjectivesWe are currently updating this cochrane systematic review on pharmacological interventions for BPD. First findings on the up-to-date evidence relating to SGAs will be presented.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) according to cochrane collaboration standards. Any randomized comparisons of drug vs. placebo, drug vs. drug, or drug vs. a combination of drugs in adult BPD patients were eligible. Primary outcomes were BPD core pathology as depicted by DSM criteria. Secondary outcomes included associated pathology, i.e., depression and anxiety, general psychopathology severity and functioning as well as tolerability and safety. Two researchers selected trials, assessed quality and extracted data independently.ResultsThe current RCT evidence on SGAs in BPD will be presented, and their use in everyday clinical care settings will critically be discussed.Disclosure of interestThe authors declare that they have no competing interest.
Prevalence of the CYP2D6*10 (C100 T) Polymorphism in psycho-neurological patients in North-Western and Siberian regions of the Russia
Authors: Shnayder N.A. , Nasyrova R.F. , Lipatova L.V. , Teplyashina V.V. , Sosina K.A. , Sivakova N.A. , Bochanova E.N. , Dmitrenko D.V. , Artyuhov I.P. , Neznanov N.G. 
Published: June 2017

IntroductionThe gene CYP2D6 is of great interest also due to its highly polymorphic nature, and involvement in a high number of medication metabolisms. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment.Materials and methodsAllele and genotype frequency distributions of CYP2D6*10 variants and predicted phenotypes were analyzed in blood samples of 123 patients (53 patients from north-western region and 69 patients from Siberian region) using polymerase chain reaction (PCR)-restriction fragment length polymorphism, PCR-single-strand conformation polymorphism.ResultsThe T/T, C/T, and C/C genotype frequencies of the CYP2D6*10 allele were significantly different (P < 0.01) in regional groups. The frequency of the wild homozygous variant C/C of the CYP2D6*10 allele (extensive metabolizers) in the Siberian region was the highest, while the north-western region of Russia had the lowest frequency (P < 0.001), which are 82.6% and 64.2%, respectively. The frequency of the heterozygous variant C/T of the CYP2D6*10 allele (intermediate metabolizers) was significantly a bit high in the north-western region, while the Siberian region of Russia had the lowest frequency (P < 0.001), which are 35.8% and 17.4%, respectively. The homozygous variant T/T of theCYP2D6*10 allele (poor metabolizers) was not identified.ConclusionThe C100T polymorphism of the CYP2D6 gene may be associated with several drug-induced reactions in patients with depression, schizophrenia, epilepsy etc. The differences in the prevalence of intermediate metabolizers in north-western and Siberian regions of Russia may be due to genetic drift and accumulation of alleles typical of European and Asian populations.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Symptoms of Anxiety During Pregnancy and Metabolism: A Pilot Metabolomics Study
Authors: Toffol E. , Elomaa A.P. , Glover V. , Kivimäki P. , Pasanen M. , Keski-Nisula L. , Huuskonen P. , Voutilainen S. , Velagapudi V. , Lehto S. 
Published: June 2017

IntroductionAnxiety symptoms are frequent during pregnancy, and they adversely affect pregnancy outcomes and offspring development. The underlying biological mechanisms are not known, but may in part be explained by alterations in certain maternal metabolic pathways. No metabolomic studies have investigated possible metabolic alterations in anxious pregnant women.ObjectiveThis pilot study compared the metabolic profiles of anxious and non-anxious pregnant women using a mass spectrometry-based quantitative metabolomics system.MethodsCases were 20 participants of the Kuopio birth cohort study (www.kubico.fi) with first and third trimester symptoms of anxiety (Edinburgh postnatal depression scale, anxiety subscale – EPDS-3A ≥ 4), but no depression (EPDS ≤ 12). Controls were 20 participants with low anxiety (EPDS–3A ≤ 3) and depression (total EPDS ≤ 9) in both the first and third trimester. Maternal metabolic profiles were analyzed from serum samples drawn when the mothers arrived at the delivery hospital.ResultsMetabolic pathway analyses revealed significant enrichment in the glycine, serine and threonine metabolism (P = 0.046), as well as in the betaine (P = 0.048) metabolism pathways. Homocysteine was the only metabolite to significantly differentiate between cases and controls (VIP score 3.3), with lower concentrations in cases (P = 0.003) even when excluding non-users of folic acid supplementation (n = 5; P = 0.002), C-sections (n = 5; P = 0.013), or samples taken immediately postpartum (n = 2; P = 0.004). No other metabolites significantly differed between the groups.ConclusionsPhysiological adaptation induced by pregnancy, which may have homogenized the study populations, could explain the only minor metabolic differences between the two groups. Further research in larger samples, comparing metabolic alterations in umbilical cord blood and maternal blood is warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The utilization of a creative strategy in the prevention of the use of psychoactive substances with children and adolescents
Authors: Jaber J. , Humel S. , Leite S. , Tomé A. , Hollanda A. , Reys B. 
Published: June 2017

IntroductionThe work describes a successful experience in the utilization of art as a tool to work the prevention of the use of drugs. The experience was developed with children and adolescents between the ages of 3 and 17 who reside in a risky area near Latin America's biggest dump, located in the city of Taguatinga, FD, Brazil.ObjectivesCreate a therapeutic space to make possible the dialog with the children and adolescents, promoting the prevention and the consciousness about the harm of the use of psychoactive substances, providing clarification on the theme, through art, being the use of formal language and terms, like “illicit drugs”, unnecessary.MethodsThe children, who participated in the project, used, as expression tool, several painting items. The public was divided by age in two groups: the children received ludic approach, allowing the team nearness and interaction with them, in such a way that the former transmitted information and guidance about the harm on the use of psychoactive substances.ResultsThe results were satisfactory. All the children and adolescents involved in the project demonstrated adhesion to the use of the offered tools and established a communication link, which allowed the receptivity of information about prevention in the use of psychoactive substances.ConclusionsThrough the developed activities, it was observed that the strategy utilization of art as a language had better effiency than a formal approach since the children and adolescents could have a learning space in a spontaneous way, demonstrating interest.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Fatigue and return-to-work in cancer patients: Association with work ability and quality of life
Authors: Monteiro S. , Bártolo A. , Andrea A. , Diana S. , Pereira A. 
Published: June 2017

IntroductionFatigue is a common and debilitating problem in cancer survivors. Research show that this symptom endures even in disease-free patients affecting quality of life. Returning to work is physically and emotionally demanding for this population and fatigue levels seems to predict the time taken to return to work and the ability of the worker.ObjectiveOur main objective was to explore the direct effect of the fatigue on work ability and quality of life of professionally active cancer survivors. Aims Fatigue levels, work ability and overall quality of life of survivors group were compared with a sample of individuals without cancer history. Relationship between fatigue symptoms and work ability and quality of life were examined within of the survivors group.MethodsThis cross-sectional study included 57 cancer survivors and 57 controls (n = 114) and data was collected from two Central Hospitals of Portugal. Participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue, the Work Ability Index and the Functional Assessment of Cancer Therapy-General.ResultsCancer survivors reported higher levels of fatigue than controls and worse work ability and quality of life (P < .001). Controlling the effect of the age and gender, fatigue of the cancer survivors group influenced negatively their overall quality of life (β= –.315, P= .013, R2= .143) but not their work ability.ConclusionsAlthough the fatigue has not affected directly the work ability of the cancer survivors, two years or more after the conclusion of the treatments, this symptom has a significant effect on the quality of life.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Illness representation as a factor of quality of life in youth with mental illnesses
Authors: Rasskazova E. , Spivakovskaya A. , Tkhostov A. 
Published: June 2017

IntroductionCognitive perspective considers beliefs as key factors of compliance and adjustment in mental disorders (Beck, 2011) that are especially important in youth. In psychosis illness, representation is related to CBT efficacy.ObjectivesWe suggest that in different mental disorders different illness-related beliefs are important for quality of life domains.AimTo reveal relationships between illness representation and quality of life in mental disorders controlling for psychopathological symptoms.MethodsOne hundred and eighteen male patients 17 – 27 years old : 33 with mood disorders, 26 with personality disorders, 27 with schizotypal disorder and 32 with schizophrenia recovering after first episode of psychosis filled Illness Perception Questionnaire, Symptom Checklist 90-R, Quality of Life and Enjoyment Questionnaire (version for mental illnesses).ResultsAfter statistical control for psychopathological symptoms, in personality disorders feeling of personal and treatment control (β = .43–.52, P < .01) as well as belief in longer (β = .42, P < .05) but not cyclic (β = –.65, P < .05) illness duration predicted satisfaction with health while belief in longer duration and less consequences correlated with better satisfaction with leisure time (β = .87, P < .01). In mood disorders, feeling of treatment control (β = .32, P < .05) and belief in shorter illness duration (β = –.37, P < .05) were related to better satisfaction in emotional sphere.ConclusionsBeliefs about illness duration, consequences and control could be important in assessment and CBT for youth with personality disorders while treatment control and illness duration are important in work with youth with mood disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.