bluuebunny/crossref_metadata_2025_split huggingface dataset:
Half-dosage of gonadotropin-releasing hormone agonist is effective for pituitary desensitization during short IVF protocol
Authors: Hsieh Jen-Hsiang , Chang Chi-Chen , Hsieh Yao-Yuan , Li Chang-Wei 
Published: September 2024

Abstract

Objectives
Gonadotropin-releasing hormone agonist (GnRHa) has been used for pituitary desensitization during controlled ovarian hyperstimulation (COH)-IVF for decades. We aimed to determine the clinical differences of half-dosage leuplin accete (LA) with the full-dosage in pituitary desensitization during short protocol COH.
Methods
All COH-IVF individuals who accepted LA for pituitary down-regulatioin were recruited. Women were divided: (1) LA 0.5 mg/day (age < 38, n = 32); (2) LA 0.25 mg/day (age < 38, n = 38); (3) LA 0.5 mg/day (age ≥38, n = 30); (4) LA 0.25 mg/day (age ≥38, n = 33). The gonadropin dosage, LH surge, OHSS risk, oocyte and embryo No., clinal pregnancy rate (CPR), and live birth rate (LBR) between each group were compared. The trial registration number and date of registration trial were retrospectively collected.
Results
The non-significantly trends of lower gonadotropin dosages and higher LH surges in the half-dosage GnRHa groups compared to full-dosage GnRHa groups were observed. Gonadotropin dosages (IU)/ E2 (pg/mL) on hCG day/LH surges in each group were: (1) 1454.4/1653.6/0%; (2) 1419.6/1683.5/3%, (3) 1954.5/910.8%/0%; and (4) 1893.5/953.6/3.7%; respectively. The oocyte No., day3 embryo No., ovarian hyperstimulation syndrome (OHSS), and CPR, LBR between half and full dosage were not statistically different between full & half LA groups. The oocyte No./day3 grade I, II embryo No/CPR/LBR in each group were: (1) 11.3 /5.6/37.5%/31.3%; (2) 11.8/5.1/39.4%/33.3%, (3) 6.5/2.6/19.2%/11.5%; and (4) 6.8/2.7/22.2%/14.8%; respectively.
Conclusions
Half-dosage GnRHa application results in comparable pituitary suppression and clinical outcomes compared to full-dosage GnRHa during short IVF protocol. The real roles of lower-dosage GnRHa upon pituitary desensitization during IVF warrant further investigation.
Research on Spatial Differentiation of Chinese High-level Athletes and Its Influence Mechanisms - Analysis Based on GIS and QCA
Authors: Chengwei Xu , Shi Bing 
Published: September 2024

Abstract

The spatial distribution of high-level athletes is one of the important indicators for judging the development of regional competitive sports. In this study, the regional distribution characteristics of high-level athletes and their influencing mechanisms in 31 provinces in mainland China were analyzed using GIS and QCA methods. The results show that: (1) there is a significant imbalance in the distribution of high-level athletes in different regions, showing a distribution pattern of more in the east and less in the west, dense along the coast and sparse in the inland; (2) there is a positive spatial correlation in the distribution, which shows the complexity of imbalance and dynamic adjustment, and maintains the overall pattern of low-level imbalance; (3) there are four types of paths contributing to the phenomenon of regional agglomeration, which belong to the categories of "technology-environment type" and "technology-environment type", which include core conditions such as investment in science and technology innovation, coaching resources, regional economic strength, and social sports organizations, and specific combinations of auxiliary conditions such as sports events, sports reserve talents, and professional sports development. The study shows that coaching resources are the core factor in all groupings.
Causal mapping of a midbrain circuit supporting 3-D vision in humans and monkeys
Authors: Friedrich Maximilian , Horn Anja , Das Vallabh , Rucker Janet , Hiew Shawn , Mayadali Ümit , Peach Robert , Butenko Konstantin , Eldebakey Hazem , Hartig Johannes , Friedrich Helen , Ip Chi Wang , Volkmann Jens , Zeller Daniel , Changizi Barbara , Dieterich Marianne , Zee David , Zwergal Andreas , Reich Martin , Fox Michael 
Published: September 2024

Abstract

Frontal-eyed species use a combination of conjugate and vergence eye movements, termed 3-D gaze, to scan their environment1–3. The neural circuits mediating conjugate gaze have been extensively characterized, but those governing vergence remain disproportionately obscure4. Here, we combine lesion and deep brain stimulation data from 67 humans and 19 monkeys to causally link vergence function to a midbrain region rostral to the superior colliculus, encompassing the nucleus of the posterior commissure (NPC), and aligning with the location of neurons whose activity correlates with vergence in monkeys5,6. Cross-species eye movement analysis suggests the NPC region houses a vergence integrator maintaining stable eye alignment in depth5,7,8. Multimodal connectivity revealed NPC connections to the pretectum and the supraoculomotor area, brain regions previously linked to visual maps of 3-D space and premotor control of the near response, enabling focus across varying viewing distances9. Collectively, these results suggest the NPC region is a key node for 3-D visuomotor transformations. These findings bridge a translational gap between physiological observations in monkeys and clinical disorders in humans, revealing a subcortical circuit for 3-D vision.
Physical Activity Level Effect on Cognitive Level And Quality Of Life in Patients with Breast Cancer: A Case Control Study Investigation Of The Relationship Between Physical Activity Level And Quality Of Life In Patients With Breast Cancer
Authors: KAHRAMAN Ayşegül , ÖZTÜRK Nazan , KARABIÇAK Gül Öznur , OKTAY Esin 
Published: September 2024

Abstract

Purpose
To determine the level of physical activity, quality of life and cognitive level in patients undergoing breast cancer treatment and to compare the results with a healthy population of similar age group.
Methods
Our case-control study was conducted with chemotherapy patients (CG) diagnosed with breast cancer (breast Ca) treated in the Department of Oncology and healthy control group (HCG) with similar demographic characteristics. he participants' physical activity level was assessed using the International Physical Activity Questionnaire (IPAQ), their quality of life using the EORTC-QLQC30 Quality of Life Scale, and their cognitive level using the Montreal Cognitive Assessment Scale. The Mann-Whitney U test was used to determine differences between groups. A level of p < 0.05 was considered statistically significant.
Results
In our study in which breast Ca (n = 38, age = 52.96 ± 11.37 years, height = 162.22 ± 6.28cm, weight = 71.07 ± 12.91kg, chemotherapy cycle = 4.33 ± 6.86 cycles) and healthy control group (n = 30, age = 51. 1 ± 12.39 years, height = 161.63 ± 6.33cm, weight = 70.23 ± 12.761kg), the physical activity level was significantly lower in the breast cancer group than in the control group (p < 0.0001, z=-4.101). Similarly, the cognitive level (p < 0.0001, z=-3.258) subscores were significantly lower in the breast ca group compared to the control group. While the overall quality of life score did not differ from healthy controls (p < 0.0001, z=-4.101), the physical, social, emotional, fatigue and vomiting subscores were significantly lower than healthy controls.
Conclusion
The level of physical activity was found to be lower in patients after breast cancer compared to their healthy counterparts. In addition, levels of social support and role functioning, which indicate quality of life, and disease-specific symptoms such as pain, nausea, vomiting, and constipation were different from those in the healthy control group. Therefore, these variables should be taken into account in the exercise programme given to breast cancer patients.
Clinical Trial Registration number: NCT05275517 Submission Date: 05/09/2023
A Novel Hybrid Ant Colony Ant lion optimization for allocation and sizing of DFACTS in Real-time reconfigured distribution system for security enhancement
Authors: Sri K , P. Mangaiyarkaras S. , Balakumar S , Jebaraj L 
Published: September 2024

Abstract

Power generation and distribution are vital processes as all loads in today's utilities are energized by the power they provide. So, delivering it efficiently is a challenging and unfulfilled task. Achieving a fully efficient distribution is still an ongoing research process. Various factors are studied and improved with the obtained results. In this paper, the optimal radial distribution network is examined, and according to our results, reconfiguration is done using a hybrid Ant Colony – Ant Lion Optimization Algorithm (HACALOA). Single incoming substation is utilized through a series of step downs and splits to achieve a balanced load. To investigate the competence of the planned method, the IEEE 33-bus system and 35-bus Indian utility system are implemented in real time using MATLAB. An analogy is made to prove the effectiveness of the planned method from the outcomes obtained using various techniques.
Stronger, Straightforward Service and Support Provision: A New Methodological Approach to Infant and Early Mental Health Care Pathway Creation Through Multisectoral Collaboration
Authors: Peterson-Katz Karys , Davis Amanda , Summers Nicole , Kulkarni Chaya , Sundar Purnima , Reynolds James N. 
Published: September 2024

Abstract

Background:
Early childhood plays a pivotal role in shaping positive mental health outcomes, yet navigating the path to appropriate services in Ontario is often hindered by fragmented systems, lack of collaboration, and unclear pathways to care.
The Infant and Early Mental Health (IEMH) Care Pathways Initiative addresses the critical need for accessible and comprehensive mental health support for at-risk children under the age of 6 in Ontario.
This paper outlines the IEMH Care Pathways methodology to develop and implement systems of care pathways that lead families with children 0-6 to, through, and out of care.
Methods:
The IEMH Care Pathways Initiative employs a 5-phased approach: 1) Community Engagement, 2) Service Mapping and Inventory Assessment, 3) Aspirational Pathway Building, 4) Ages and Stages Questionnaire and Developmental Support Plan Training and Implementation, and 5) Aspirational Pathway Implementation. Evaluation throughout the process is informed by the Consolidated Framework for Implementation Research.
Conclusions:
The IEMH Care Pathways methodology represents a significant step forward in promoting positive mental health outcomes and overall well-being for children before they reach school age. By prioritizing the science of brain development, early developmental delay identification, and access to timely and appropriate support services, the process presented aims to mitigate the risk of adverse outcomes and increase opportunities for positive developmental trajectories. Continued efforts to refine and expand upon the methodology outlined in this paper are underway. Through collaborative partnerships and equitable access to care, a more cohesive and effective system to ensure healthier communities can be created.
Indication of p + 11 B Reaction in Laser Induced Nanofusion Experiment
Authors: Kroó N. , Csernai L. P. , Papp I. , Kedves M. A. , Aladi M. , Bonyár A. , Szalóki M. , Osvay K. , Varmazyar P. , Biró T. S. 
Published: September 2024

Abstract

The NAPLIFE project proposed fusion by regulating the laser light absorption via resonant nanorod antennas implanted into hydrogen rich urethane acrylate methacrylate (UDMA) and triethylene glycol dimethylacrylate (TEGDMA) copolymer targets. In part of the tests, boron-nitride (BN) was added to the polymer. Our experiments with resonant nanoantennas accelerated protons up to 225 keV energy. Some of these protons then led to p + 11B fusion, indicated by the sharp drop of observed backward proton emission numbers at the 150 keV resonance energy of the reaction. The generation of alpha particles was verified by CR-39 plastic track detectors.
Albumin Nanoparticle enhances Oxaliplatin concentration in the Colorectal region to treat Colon Cancer with increased efficacy
Authors: Wilson Barnabas , KM Geetha , Divekar Kalpana , Jenita Josephine Leno , Premakumari Kudumula B. , Sagar Girisha 
Published: September 2024

Abstract

Site specific delivery of anticancer drugs into tumour cells increase therapeutic efficacy while decreasing unwanted side effects. Oxaliplatin (Oxa) is a third-generation platinum derivative used to treat advanced colorectal cancer (CRC). Oxaliplatin loaded bovine serum albumin nanoparticles (Nps-Bsa-Oxa) were formulated by desolvation method. The Nps-Bsa-Oxa were characterized for their size, zeta potential (ZP), surface morphology and charge, in vitro Oxa release, release kinetics, in vitro cytotoxicity, and in vivo studies. The size and surface charge of the Nps-Bsa-Oxa was found to be 163.2 ± 6.3nm and − 27 mV respectively. The Oxa release was studied by dialysis, revealing a biphasic release pattern. In vitro cytotoxicity study was carried out by MTT assay using HT29 cell lines and the Nps-Bsa-Oxa showed higher cytotoxicity when compared with free drug Oxa. In vivo studies on animals revealed that Nps-Bsa-Oxa delivered more Oxa to the colonic region compared to the free form of the drug Oxa.
Revision and Validation of the “Motivational Climate in Physical Education Scale” (MCPES) in Chinese educational context
Authors: zhang qiang , Sun Yingying , Fan Erzhen , Deng Wenjing 
Published: September 2024

Abstract

This study evaluated the reliability and validity of the Chinese version of the “Motivational Climate in Physical Education Scale” (MCPES) among middle school students. Data were collected from 1,010 students, with 473 completing the MCPES, the Physical Needs Support in Physical Education Scale (PNS-PE), and the Youth Sports Friendship Scale (YFQS). Additionally, 437 students completed only the MCPES, and 200 valid retest questionnaires were gathered three weeks later. Exploratory factor analysis identified four factors: perceived autonomy support, perceived social relationship support, perceived task involvement support, and perceived self-involvement support, with a total of 16 items. Confirmatory factor analysis supported the four-factor structure (χ2/df = 3.38, GFI = 0.92, NFI = 0.90, RMSEA = 0.07, CFI = 0.93, IFI = 0.93, SRMR = 0.05). The scale exhibited strict measurement invariance across genders and strong invariance across grade levels. It was positively correlated with teacher autonomy support (r = 0.34–0.53) and with each dimension and total score of sports friendship (r = 0.21–0.61). Cronbach’s α coefficients for the MCPES and its dimensions were 0.75, 0.82, 0.79, 0.80, and 0.88, respectively. Intraclass correlation coefficients (ICCs) for the three-week retest were 0.64, 0.63, 0.72, and 0.76. In conclusion, the Chinese version of the MCPES demonstrates robust reliability and validity for use with middle school students.
Global Solar Radiation Estimation from meteorological Temperature data for Samara City, Ethiopia
Authors: Anshebo Getachew Alemu 
Published: September 2024

Abstract

In this study, several regression models were employed to estimate global solar radiation from commonly available meteorological data such as temperature, for meteorological stations of samara city Afar region..A location's solar radiation availability is a crucial consideration when choosing the right solar energy system and accessories for a range of uses. The greatest and lowest temperatures recorded at Samara City (11..81°N, 41.16°E), over a five-year period (2013–2017) were utilized to create Angstrom-type regression equations, or models, for calculating the total solar radiation that Samara City received on a horizontal surface. In order to determine the effectiveness of the models, the correlation results were also checked for errors using statistical test methods such as mean bias error (MBE), root mean square error (RMSE), and mean percentage error (MPE). It was found that temperature data can be applied to calculate the total amount of solar radiation incident on a Samara City, with a very reasonable degree of precision.
Microwave irradiation as a novel strategy for mitigating airborne transmission of highly pathogenic avian influenza A(H5N1) virus: an optimization study
Authors: Bia Pietro , Losardo Margherita , Manna Antonio , Brusaferro Silvio , Privitera Gaetano P. , Vincentelli Alberto Sangiovanni 
Published: September 2024

Abstract

The highly pathogenic avian influenza A(H5N1) virus threatens animal and human health globally. Innovative strategies are needed to reduce airborne transmission and prevent outbreaks. This study investigated the efficacy of microwave inactivation against aerosolized A(H5N1) by (1) identifying the optimal frequency band in 10 min of exposure and (2) evaluating the effect of exposure time.
A(H5N1) was aerosolized and exposed to various microwave frequencies (between 8 and 16 GHz with different ranges) for 10 minutes. Viral titers were quantified using TCID50, and inactivation was assessed by comparing irradiated samples to controls. The 11−13 GHz band resulted in the highest inactivation, with an average of 89% mean reduction in A(H5N1) titer in particular in the range of 11-12 GHZ (pick of efficacy). Considering the overall tests and results, the optimal band (8-12 GHZ) was further tested with 1, 3, and 5-minute exposures. Inactivation was time-dependent, with 5-minute exposure yielding a 94% mean reduction, compared to 58% and 48% for 3 and 1-minute exposures, respectively. Optimized microwave emitters in high-risk environments like poultry farms and veterinary clinics could offer a novel, non-chemical approach to mitigating avian influenza spread and outbreaks.
Characterizing High-risk Population with Metabolic Syndrome based on Extreme Logistic Regression
Authors: Ling Chengxiu , Bai Long , Zhu Xiaojun , Shi Dongping , Wang Hongliang , Wu Han , Wang Kai , Zhou Feng , Wen Zhongmin 
Published: September 2024

Abstract

Metabolic syndrome (MetS), as a potential factor leading to diabetes and cardiovascular diseases, has attracted increasing global attention, especially on its identification and intervention.This study aims to characterize high-risk individuals with MetS based on an extreme logistic regression (ELR) model. Five key factors of waist circumference (WC), fasting plasma glucose (FPG), blood pressure (including systolic blood pressure (SBD) and diastolic blood pressure (DBP), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) are incorporated in an extreme function to predict the severity of MetS. The individuals with high-risk MetS are uniformly identified with the estimated cut-offs of predictors and prediction rules of the MetS population simultaneously. Typically, the identified individuals with higher-risk MetS under extreme diagnostic criteria are more likely to experience a greater burden of relevant diseases. We conclude that the innovative diagnosis criteria for MetS have significant implications for clinical warning, effective intervention strategies, and better resource allocation in clinical settings.
Biotechnological properties of Bacillus amylolyquefaciens B65, strain isolated from an artisanal tannery
Authors: Alemán María Virgili , Petroselli Gabriela , Erra Rosa , Daz Mirta , Audisio Marcela 
Published: September 2024

Abstract

Leather industry is traditionally characterized by the use of large amounts of chemical agents, some of which are toxic for human health and the environment. However, during the last years, many efforts have been made with the aim of successfully implement enzymes as agents for different leather production stages. The lipopeptides produced by the Bacillus spp. genus have excellent surfactants and antibacterial properties and may collaborate in the soaking stage of leather processing as well as in the leather preservation. Moreover, Bacillus sp. proteases and lipopeptides can be co-produced in one culture medium, saving the production costs. In the present work, a screening of enzymatic activities was performed to 11 strains of the Bacillus sp. genus that have been isolated from samples of an artisan tannery from Salta, Argentina. In particular, the ability of B. amyloliquefaciens B65 to degrade α-type (nails, hair, wool) and β-type (feathers) keratin was demonstrated by scanning electron microscopy (SEM). The co-production of proteases, keratinases, glycosidases and lipopeptides of this strain was conducted at 37°C in mineral media supplemented with chicken feathers. In these nutrient-poor media, the strain secreted amylases, pectinases, proteases, keratinases, and collagenases. A MALDI-TOF study also revealed that the strains secreted homologues of kurstakins, iturins, surfactins and fengycines lipopeptides families. Therefore, B. amyloliquefaciens B65 presents great industrial potential applications, not only for tanneries but also for other industries such as pharmaceuticals, food, textiles and detergents, among others.
Racism in Clinical Nursing Practice: A Qualitative Study
Authors: Crenshaw Nichole , Lewis LaToya , Foronda Cynthia 
Published: September 2024

Abstract

Background
Racism in healthcare has led to disparate health outcomes amongst people of color. The construct of racism may be misunderstood, and research is lacking about the actions nurses can in the clinical setting take to reduce racism. The purpose of the study was to determine behaviors demonstrative of racism in nursing care and behaviors that are demonstrative of cultural humble nursing care to develop an awareness of racial bias in nursing to inform future educational practices.
Methods
A qualitative, descriptive design was used with 10 doctoral-prepared nurses of color with expertise in diversity, equity, inclusion, and social determinants of health.
Findings
Three overarching themes emerged: 1) Experience of Racism as a Nurse of Color (with subthemes of False Negative Assumptions/Stereotyping, Discrediting/Unheard, and Rejection), 2) Experience of Racism as a Patient of Color (with subthemes of False Negative Assumptions/Stereotyping, Inequitable Treatment/ Lack of Care, and Dismissing/Ignoring or Not Believing), and 3) Culturally Humble Care (with subthemes of Asking, Active Listening, Caring Body Language, Individualized Care, and Respect).
Conclusions
Study findings may be used to inform and improve nursing practice to reduce racism and decrease health disparities.