bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the Novel Ventilation Mode FLow-Controlled EXpiration (FLEX): A Crossover Proof-of-Principle Study in Lung-Healthy Patients
Authors: Wirth Steffen , Springer Sebastian , Spaeth Johannes , Borgmann Silke , Goebel Ulrich , Schumann Stefan 
Published: April 2017

BACKGROUND:
Traditionally, mechanical ventilation is achieved via active lung inflation during inspiration and passive lung emptying during expiration. By contrast, the novel FLEX (FLow-controlled EXpiration) ventilator mode actively decreases the rate of lung emptying. We investigated whether FLEX can be used during intraoperative mechanical ventilation of lung-healthy patients.

METHODS:
In 30 adult patients scheduled for neurosurgical procedures, we studied respiratory system mechanics, regional ventilation, oxygenation, and hemodynamics during ventilation with and without FLEX at positive end-expiratory pressure (PEEP) of 5 and 7 cm H2O. The FLEX system was integrated into the expiratory limb and modified the expiratory flow profile by continuously changing expiratory resistance according to a computer-controlled algorithm.

RESULTS:
Mean airway pressure increased with PEEP by 1.9 cm H2O and with FLEX by 1 cm H2O (all P < .001). The expiratory peak flow was 42% lower with FLEX than without FLEX (P < .001). FLEX caused significant shifts in aeration from ventral to the dorsal lung regions. Respiratory mechanics, end-tidal carbon dioxide partial pressure, oxygenation, and hemodynamics were independent from FLEX and PEEP. We observed no critical incidents or FLEX malfunctions in any measurement that would have required an intervention or termination of the FLEX mode.

CONCLUSIONS:
FLEX can be used in lung-healthy patients who are mechanically ventilated during general anesthesia. FLEX improves the homogeneous distribution of ventilation in the lungs.
Determination of Perioperative Blood Loss: Accuracy or Approximation?
Authors: Lopez-Picado A. , Albinarrate A. , Barrachina Borja 
Published: April 2017

BACKGROUND:
Various different interventions can be used to reduce surgical blood loss; however, there is no “gold standard” for accurately measuring the volume of perioperative blood loss, and this makes it difficult to assess the efficacy of these interventions.

METHODS:
We used data from a previous multicenter double-blind randomized clinical trial in patients undergoing total hip arthroplasty in which we compared 2 regimens for administering tranexamic acid versus placebo. We assessed direct measures (external blood loss) and indirect estimates (using the formulas of Bourke, Gross, Mercuriali, and Camarasa and a new formula we have developed) using analysis of variance to compare estimated volumes of blood loss among the study groups. In addition, intraclass correlation coefficients (ICCs) and Bland–Altman diagrams were used to compare the estimated volumes of blood loss obtained with each formula.

RESULTS:
The mean estimated external blood loss was 909 ± 324 mL, and the mean estimates of blood loss calculated using the formulas of Gross, Bourke and Smith, and Camarasa were 1308 ± 555, 1091 ± 454, and 1641 ± 945 mL, respectively, whereas we obtained a value of 1511 ± 919 mL with the new formula at day 2. In all cases, the results favored the use of tranexamic acid (P < .0001). Comparing results of the new and other formulas, we found moderate-to-low agreement (in terms of ICCs) except for that of Camarasa (ICC: 0.992). The limits of agreement with the new formula ranged from −378 to 93 in the case of the comparison with Camarasa’s formula and from −2226 to 959 for external blood loss, the difference depending on the magnitude of the estimate to a large extent.

CONCLUSIONS:
Formulas that take into account both anthropometric and laboratory parameters are useful for evaluating the efficacy of interventions aiming to decrease blood loss but do not ensure that the values obtained are sufficiently accurate for absolute measuring.
Development and dynamics of cell polarity at a glance
Authors: Campanale Joseph P. , Sun Thomas Y. , Montell Denise J. 
Published: April 2017

ABSTRACT
Cells exhibit morphological and molecular asymmetries that are broadly categorized as cell polarity. The cell polarity established in early embryos prefigures the macroscopic anatomical asymmetries characteristic of adult animals. For example, eggs and early embryos have polarized distributions of RNAs and proteins that generate global anterior/posterior and dorsal/ventral axes. The molecular programs that polarize embryos are subsequently reused in multiple contexts. Epithelial cells require apical/basal polarity to establish their barrier function. Migrating cells polarize in the direction of movement, creating distinct leading and trailing structures. Asymmetrically dividing stem cells partition different molecules between themselves and their daughter cells. Cell polarity can develop de novo, be maintained through rounds of cell division and be dynamically remodeled. In this Cell Science at a Glance review and poster, we describe molecular asymmetries that underlie cell polarity in several cellular contexts. We highlight multiple developmental systems that first establish cell/developmental polarity, and then maintain it. Our poster showcases repeated use of the Par, Scribble and Crumbs polarity complexes, which drive the development of cell polarity in many cell types and organisms. We then briefly discuss the diverse and dynamic changes in cell polarity that occur during cell migration, asymmetric cell division and in planar polarized tissues.
Relations between gestational diabetes and
postpartum depressive disorders and symptoms
Authors: Zwolińska- Kloc Magda , Zabel Monika , Czajkowski Krzysztof , Ostasz- Ważny Joanna , Kokoszka Andrzej 
Published: April 2017

Aim of the studyTo examine whether Polish women with type 2 diabetes suffer from sexual dysfunction/dissatisfaction, and if so, to investigate the connection between the severity of sexual problems and well-being, anxiety and depression in this group of women.Subject or material and methodsWe surveyed 60 women aged 42-72 years old, M = 59.25 (SD = 9.14). The study was based on the following questionnaires: the Arizona Sexual Experience Scale (ASEX), Sexological Questionnaire Part B, the WHO-5 Well-Being Index, the Brief Self-Rating Scale of Depression and Anxiety.ResultsA total of 75% (N = 45) of the respondents complained of the absence of orgasm (anorgasmia), 63.3% (N = 38) showed a lack or loss of sexual desire, and 50% (N = 30) had no genital response to sexual stimuli and/or experienced sexual aversion. There was also no significant relationship between wellbeing, the presence of anxiety and depressive symptoms, and the severity of sexual dysfunction.DiscussionThe current study has significant limitations due to the small number of participants and the lack of a pair matched control group. Our findings indicate higher frequency of SD than other studies. The differences should be interpreted with caution and it would be important to confirm these results in future studies, with a larger group of participants.ConclusionsPolish women with type 2 diabetes commonly have symptoms of sexual dysfunction. Well-being, depressive and anxiety symptoms appear to co-occur with symptoms of sexual dysfunctions.
Pathological use of mobile phones by secondary
school students
Authors: Warzecha Katarzyna , Pawlak Adam 
Published: April 2017

Aim of the studyThe dangers resulting from the dysfunctional use of mobile phones by adolescents are presented in the study. The main aim of the conducted study was the exploration of addiction to mobile phones used by secondary students as well as the presentation of differences in addiction to mobile phones in group of women and men.
470 Polish secondary students from Silesia took part in the study.Subject or material and methodsThe author’s distributed questionnaire which contained questions concerning the types of the Internet activity, the aims and intensity of use of modern means of communication (computers with the Internet access and the mobile phones) and the Survey form and the Mobile Phone Addiction Assessment Questionnaire (KBUTK) by Potembska and Pawłowska were used in the study.ResultsThe criteria of being at risk of mobile phone addiction were fulfilled by about 35% of tested students and about 4% of students were addicted to mobile phones. Analyzing the level of addiction to mobile phones by gender, it can be stated that more women than men fulfill the criteria of being addicted and being at risk of addiction to mobile phones.DiscussionThe obtained results proved the hypothesis formulated in the study which assumed that there are statistically significant differences between the students who correctly and pathologically use mobile phones in total and by gender.ConclusionsThe problematic use of mobile phones by the adolescents may be a cause of health problems and social expense.
Child self-esteem and different parenting styles of
mothers: a cross-sectional study
Authors: Firouzkouhi Moghaddam Mahboubeh , Rakhshani Tayebeh , Assareh Marzieh , Validad Atiye 
Published: April 2017

Aim of the studySeveral factors affect the formation of self-esteem in children. Given the importance of parental attitudes and educational practices in development of a sense of self-worth in children, this study aimed to investigate the relationship between parenting styles and self-esteem in primary school children .Subject or material and methodsThis cross-sectional study was conducted on primary school children in Zahedan during 2013-2014. The data were collected using Cooper-Smith Self-Esteem Inventory and Diana Baumrind Parenting Style Inventory. Then, the data were described using mean, standard deviation, and frequency, and were analyzed using multivariate regression analysis and Pearson’s correlation coefficient. All analyses were performed using the SPSS statistical software, version 16.frequency, and multivariate regression test as well as Pearson correlation coefficient was applied for data analysis. The SPSS software version 16 was also used for data analysisResultsThe results showed that the total mean score of self-esteem was 32.5±5.6 and most parenting styles were authoritative (80.6%). In addition, a significant relationship was found between self-esteem and authoritative parenting style (p<0.05).DiscussionAccording to the present study, the data related to predict self-esteem through the use of parenting styles indicated that authoritative parenting style is a significant predictor of self-esteem. Furthermore, authoritative parenting style is a significant predictor of a child's self-esteem and this suggests that self-esteem is significantly higher in those who have parents with authoritative parenting styleConclusionsThe study results indicated that authoritative parenting style was a significant predictor of children’s self-esteem. In other words, children of parents with authoritative parenting style had significantly higher self-esteem.
Using arts psychotherapy in psycho-oncology
as a means of coping with stress and anxiety
Authors: Schiltz Lony , Zimoch Amelia 
Published: April 2017

Aim of the studyAccording to the state- of-the-arts in psycho-oncology, cancer, as well as the accompanying medical treatments, is a source of intense emotional stress.
As arts psychotherapies favour the imaginary and symbolic elaboration of the tensions of daily life, as well as the re-appropriation of one’s body and personal history, it could play an important role in treatment measures for patients suffering from cancer.Subject or material and methodsWe present an exploratory study with patients treated in an acute cancer ward or in outpatient settings (total N= 42). They assisted to 12 sessions of arts psychotherapy adapted to their physical condition. The evaluation study is based on a mixed methods design, combining the qualitative and quantitative exploration of stories written under musical induction with the qualitative analysis of a final semi-structured interview.ResultsThe comparative and multidimensional analysis of the texts documents a significant evolution. Themes of existential importance come out of the phenomenological analysis of the semi-structured interview, and the cross checking of the texts and the interview points to recurrent categories.DiscussionThe findings are discussed at the light of the state-of-the-arts in psycho-oncology and psycho-traumatology. The specific action of arts psychotherapy is analysed.ConclusionsArts psychotherapy could become a valuable treating option within a multidisciplinary biopsychosocial approach in psycho-oncology, provided that certain precautions are taken.
Thirty years’ follow-up of depressive adolescents:
a preliminary report
Authors: Bomba Jacek , Modrzejewska Renata , Pilecki Maciej , Pac Agnieszka 
Published: April 2017

Aim of the studyThe purpose of the study was to describe consequences of depression in adolescence. The history of health problems and the choice of life careers, were selected as indicators of the nature of depressive syndromes appearing through adolescence. Since the ’70s, adolescent depression has been discussed to be related to developmental crisis or a form of affective disorder.Subject or material and methodsThe methods employed for this baseline study was screening youngsters of school age. A sample of youngsters from different schools and different backgrounds were screened through Kraków Depression Inventory (KID) in 1985. There was a second study done 15 years later and a third study 30 years later. The questionnaires written by original authors were sent out. A preliminary analysis of the responses to the third study is presented.ResultsThe results showed that there were no significant differences, between depressive students and the non depressive peer group.DiscussionDiscussion: the correspondence method which was employed was found to be limited, as there was a small number of replies received and therefore, they have limited the significance of our findings. Nevertheless it was found that the differences, between the life health histories of the group studied and that of a non depressive peer group were negligible or not at all.ConclusionsConclusion: results of long term prospective study, support the conception of developmental character of adolescent depression.
Leisure Activity and Caregiver Involvement in Middle-Aged and Older Adults With Down Syndrome
Authors: Mihaila Iulia , Hartley Sigan L. , Handen Benjamin L. , Bulova Peter D. , Tumuluru Rameshwari V. , Devenny Darlynne A. , Johnson Sterling C. , Lao Patrick J. , Christian Bradley T. 
Published: April 2017

Abstract
The present study examined leisure activity and its association with caregiver involvement (i.e., residence and time spent with primary caregiver) in 62 middle-aged and older adults with Down syndrome (aged 30–53 years). Findings indicated that middle-aged and older adults with Down syndrome frequently participated in social and passive leisure activities, with low participation in physical and mentally stimulating leisure activities. Residence and time spent with primary caregiver were associated with participation in physical leisure activity. The findings suggest a need for support services aimed at increasing opportunities for participating in physical and mentally stimulating leisure activity by middle-aged and older adults with Down syndrome. These support services should partner with primary caregivers in order to best foster participation in physical leisure activity.
Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut
Authors: Kuga Daisuke , Ushida Kaori , Mii Shinji , Enomoto Atsushi , Asai Naoya , Nagino Masato , Takahashi Masahide , Asai Masato 
Published: April 2017

Summary Tuft cells (TCs) are minor components of gastrointestinal epithelia, characterized by apical tufts and spool-shaped somas. The lack of reliable TC-markers has hindered the elucidation of its role. We developed site-specific and phosphorylation-status–specific antibodies against Girdin at tyrosine-1798 (pY1798) and found pY1798 immunostaining of mouse jejunum clearly depicted epithelial cells closely resembling TCs. This study aimed to validate pY1798 as a TC-marker. Double-fluorescence staining of intestines was performed with pY1798 and known TC-markers, for example, hematopoietic-prostaglandin-D-synthase (HPGDS), or doublecortin-like kinase 1 (DCLK1). Odds ratios (ORs) were calculated from cell counts to determine whether two markers were attracting (OR<1) or repelling (OR>1). In consequence, pY1798 signals strongly attracted those of known TC-markers. ORs for HPGDS in mouse stomach, small intestine, and colon were 0 for all, and 0.08 for DCLK1 in human small intestine. pY1798-positive cells in jejunum were distinct from other minor epithelial cells, including goblet, Paneth, and neuroendocrine cells. Thus, pY1798 was validated as a TC-marker. Interestingly, apoptosis inducers significantly increased relative TC frequencies despite the absence of proliferation at baseline. In conclusion, pY1798 is a novel TC-marker. Selective tyrosine phosphorylation and possible resistance to apoptosis inducers implied the activation of certain kinase(s) in TCs, which may become a clue to elucidate the enigmatic roles of TCs.
Improving Stability and Convergence for Adaptive Radial Basis Function Neural Networks Algorithm. (On-Line Harmonics Estimation Application)
Authors: Almaita Eyad K , Al shawawreh Jumana 
Published: April 2017

In this paper, an adaptive Radial Basis Function Neural Networks (RBFNN) algorithm is used to estimate the fundamental and harmonic components of nonlinear load current. The performance of the adaptive RBFNN is evaluated based on the difference between the original signal and the constructed signal (the summation between fundamental and harmonic components). Also, an extensive investigation is carried out to propose a systematic and optimal selection of the Adaptive RBFNN parameters. These parameters will ensure fast and stable convergence and minimum estimation error. The results show an improving for fundamental and harmonics estimation comparing to the conventional RBFNN. Also, the results show how to control the computational steps and how they are related to the estimation error. The methodology used in this paper facilitates the development and design of signal processing and control systems.Article History: Received Dec 15, 2016; Received in revised form Feb 2nd 2017; Accepted 13rd 2017; Available onlineHow to Cite This Article: Almaita, E.K and Shawawreh J.Al (2017) Improving Stability and Convergence for Adaptive Radial Basis Function Neural Networks Algorithm (On-Line Harmonics Estimation Application). International Journal of Renewable Energy Develeopment, 6(1), 9-17.http://dx.doi.org/10.14710/ijred.6.1.9-17
OPTIMASI PRODUKSI PULP FORMACELL DARI TANDAN KOSONG KELAPA SAWIT (TKKS) DENGAN METODE PERMUKAAN RESPON
Authors: Hidayati Sri , Zuidar Ahmad Sapta , Fahreza Ahmad 
Published: April 2017

ABSTRACT Empty oil-palm bunches (EOPB) contains more enough cellulose so that it can be made as an alternative pulp production. One of the process of pulp production which friendly environment is by using acetate acid and formic acid called by formacell process. The aims of the research is to got optimation models of formic acid concentration, HCl concentration and cooking duration for the EFB pulp production. The optimum result of the EOPB pulp production were 75% of cellulose, 8% of hemiselulosa, 10% of lignin, and 80% of yield with the optimum concentration 20% of formic acid, 0,5% of HCl, and 2 hour of cooking duration. Keyword : pulp formacell, EFB, RSM. ABSTRAK Tandan kosong kelapa sawit (TKKS) mengandung kadar selulosa yang cukup tinggi sehingga dapat dijadikan sebagai bahan baku alternatif produksi pulp. Salah satu proses produksi pulp ramah lingkungan yaitu dengan menggunakan campuran pelarut asam asetat dan asam formiat sebagai bahan pemasak yang disebut proses formacell. Tujuan dari penelitian ini untuk mendapatkan model optimasi dari konsentrasi asam formiat, konsentrasi HCl dan lama pemasakan untuk produksi pulp TKKS. Konsentrasi pemasakan optimum terjadi pada konsentrasi asam formiat 20%, konsentrasi HCl 0,5%, dan lama pemasakan selama 2 jam dengan hasil optimum untuk produksi pulp TKKS yaitu 75 % selulosa, 8 % hemiselulosa, 10% lignin, dan 80% rendemen. Kata kunci: pulp formacell, TKKS, RSM.
Origins of Adulthood Personality: The Role of Adverse Childhood Experiences
Authors: Fletcher Jason M. , Schurer Stefanie 
Published: April 2017

Abstract
We test whether adverse childhood experiences – exposure to parental maltreatment and its indirect effect on health – are associated with age 30 personality traits. We use rich longitudinal data from a large, representative cohort of young US Americans and exploit the differences across siblings to control for the confounding influences of shared environmental and genetic factors. We find that maltreatment experiences are significantly and robustly associated with neuroticism, conscientiousness, and openness to experience, but not with agreeableness and extraversion. High levels of neuroticism are linked to sexual abuse and neglect; low levels of conscientiousness and openness to experience are linked to parental neglect. The estimated associations are significantly reduced in magnitude when controlling for physical or mental health, suggesting that adolescent health could be one important pathway via which maltreatment affects adulthood personality. Maltreatment experiences, in combination with their health effects, explain a significant fraction of the relationship between adulthood conscientiousness and earnings or human capital. Our findings provide a possible explanation for why personality traits are important predictors of adulthood labor market outcomes.
A Nonspeculation Theorem with an Application to Committee Design
Authors: Chen Jidong , Fey Mark , Kristopher W. Ramsay 
Published: April 2017

AbstractVarious well known agreement theorems show that if players have common knowledge of actions and a “veto" action is available to every player, then they cannot agree to forgo a Pareto optimal outcome simply because of private information in settings with unique equilibrium. We establish a nonspeculation theorem which is more general than previous results and is applicable to political and economic situations that generate multiple equilibria. We demonstrate an application of our result to the problem of designing an independent committee free of private persuasion.
Stability of Equilibrium Outcomes under Deferred Acceptance: Acyclicity and Dropping Strategies
Authors: Tello Benjamín 
Published: April 2017

AbstractWe consider two-sided many-to-one matching markets where hospitals have responsive preferences. In this context, we study the preference revelation game induced by the student-proposing deferred acceptance mechanism. We show that acyclicity of the hospitals’ preference profile (Romero-Medina and Triossi 2013a. “Acyclicity and Singleton Cores in Matching Markets.” Economics Letters 118 (1):237–9) is a necessary and sufficient condition to ensure that the outcome of every Nash equilibrium in which each hospital plays a dropping strategy is stable.