bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survey of guidelines and current practices for safe handling of antineoplastic and other hazardous drugs used in 24 countries
Authors: Mathias Patricia I , MacKenzie Barbara A , Toennis Christine A , Connor Thomas H 
Published: August 2017

Purpose A survey of guidelines and current practices was conducted to examine the safe handling procedures for antineoplastic and other hazardous drugs that are used in 24 countries including the Americas, Europe, the Mideast, Far East, and Australia. Methods Subject experts were asked to complete a brief survey regarding safe handling guidelines and practices for hazardous drugs in their countries. Questions addressed practices for handling monoclonal antibodies, the use of closed-system transfer devices, medical surveillance practices, and measurements of compliance with existing guidelines. Results Responses from 37 subject experts representing 24 countries revealed considerable variation in the content and scope of safe handling guidelines and pharmacy practices among the participating countries. Guidelines in the majority of countries used the term “cytotoxics,” while others referred to “hazardous” or “antineoplastic” drugs. The International Society of Oncology Pharmacy Practice standard was cited by six countries, and five cited the National Institute for Occupational Safety and Health Alert. Others cited international guidelines other than International Society of Oncology Pharmacy Practice, or they have created their own guidelines. Approximately half reported that their guidelines were mandatory under federal, state, or provincial legislation. Only 11 countries reported that monoclonal antibodies were covered in their guidelines. Closed-system drug-transfer devices are widely used, but were not specifically recommended in four countries, while one country required their use. Medical surveillance programs are in place in 20 countries, but only in The Netherlands is surveillance mandatory. Nine countries reported that they have completed recent updates or revisions of guidelines, and the measures for their adoption have been initiated. Conclusions Although the overall goals in the participating countries were similar, the approaches taken to assure safe handling of hazardous drugs varied considerably in some cases.
Association between physical activity and risk of nonalcoholic fatty liver disease: a meta-analysis
Authors: Qiu Shanhu , Cai Xue , Sun Zilin , Li Ling , Zügel Martina , Steinacker Jürgen Michael , Schumann Uwe 
Published: August 2017

Background: Increased physical activity (PA) is a key element in the management of patients with nonalcoholic fatty liver disease (NAFLD); however, its association with NAFLD risk has not been systematically assessed. This meta-analysis of observational studies was to quantify this association with dose–response analysis. Methods: Electronic databases were searched to January 2017 for studies of adults reporting the risk of NAFLD in relation to PA with cohort or case-control designs. Studies that reported sex-specific data were included as separate studies. The overall risk estimates were pooled using a random-effects model, and the dose–response analysis was conducted to shape the quantitative relationship. Results: A total of 6 cohort studies from 5 articles with 32,657 incident NAFLD cases from 142,781 participants, and 4 case-control studies from 3 articles with 382 NAFLD cases and 302 controls were included. Compared with the lowest PA level, the highest PA level was associated with a risk reduction of NAFLD in cohort [RR (risk ratio) 0.79, 95% CI (confidence interval) 0.71–0.89] and case-control studies [OR (odds ratio) 0.43, 95% CI 0.27–0.68]. For cohort studies, both highest and moderate PA levels were superior to the light one in lowering NAFLD risk ( pfor interaction = 0.006 and 0.02, respectively), and there was a log-linear dose–response association ( pfor nonlinearity = 0.10) between PA and NAFLD risk [RR 0.82 (95% CI 0.73–0.91) for every 500 metabolic equivalent (MET)-minutes/week increment in PA]. Conclusions: Increased PA may lead to a reduced risk of NAFLD in a dose-dependent manner, and the current guideline-recommended minimum PA level that approximates to 500 MET-minutes/week is able to moderately reduce the NAFLD risk.
Baseline serum bicarbonate levels independently predict short-term mortality in critically ill patients with ischaemic cardiogenic shock
Authors: Wigger Olivier , Bloechlinger Stefan , Berger David , Häner Jonas , Zanchin Thomas , Windecker Stephan , Räber Lorenz , Schefold Joerg C 
Published: August 2017

Background:Cardiogenic shock is a feared complication of acute myocardial infarction with high mortality rates. Data on the predictive role of acid base dysregulation in this clinical setting are sparse. We therefore embarked on investigating the predictive role of serum bicarbonate in critically ill intensive care unit (ICU) patients with cardiogenic shock.Methods:A total of 165 ischaemic cardiogenic shock patients (118 men, aged 68.4 years (interquartile range 59.0–77.4), APACHE II score 26.0 (interquartile range 21.0–29.0), after percutaneous coronary intervention were included in a single-centre analysis. Percutaneous coronary intervention-related data such as left ventricular ejection fraction and laboratory indices were recorded and routine clinical follow-up was obtained at hospital discharge and at one year. All-cause mortality was assessed and data were analysed using univariate and multivariate models.Results:All-cause mortality was highest (17%) during the first 48 hours following ICU admission (28-day mortality rate 43%). In a multiple regression model, age (hazard ratio (HR) 1.035, 95% confidence interval (CI) 1.011–1.059, P=0.004), APACHE II score (HR 1.036, 95% CI 1.002–1.072, P=0.037) and baseline serum bicarbonate levels (HR 0.93, 95% CI 0.866–0.998, P=0.046) independently predicted 28-day mortality (overall model fit χ222.9, P<0.0001). The HR for patients in the lowest baseline serum bicarbonate tertile for 365-day mortality was HR 2.06 (95% CI 1.20–3.53).Conclusions:In a large cohort of consecutive cardiogenic shock patients hospitalised in the ICU, low serum bicarbonate levels at admission independently predicted mortality. Given the widespread availability of blood gas analysers in ICUs, we propose baseline serum bicarbonate levels as an additional biomarker for identification and stratification of cardiogenic shock patients at risk.
Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial
Authors: Fabris Enrico , van ’t Hof Arnoud , Hamm Christian W , Lapostolle Frédéric , Lassen Jens F , Goodman Shaun G , ten Berg Jurriën M , Bolognese Leonardo , Cequier Angel , Chettibi Mohamed , Hammett Christopher J , Huber Kurt , Janzon Magnus , Merkely Béla , Storey Robert F , Zeymer Uwe , Cantor Warren J , Tsatsaris Anne , Kerneis Mathieu , Diallo Abdourahmane , Vicaut Eric , Montalescot Gilles 
Published: August 2017

Background: In the ATLANTIC (Administration of Ticagrelor in the catheterization laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery) trial the early use of aspirin, anticoagulation, and ticagrelor coupled with very short medical contact-to-balloon times represent good indicators of optimal treatment of ST-elevation myocardial infarction and an ideal setting to explore which factors may influence coronary reperfusion beyond a well-established pre-hospital system. Methods: This study sought to evaluate predictors of complete ST-segment resolution after percutaneous coronary intervention in ST-elevation myocardial infarction patients enrolled in the ATLANTIC trial. ST-segment analysis was performed on electrocardiograms recorded at the time of inclusion (pre-hospital electrocardiogram), and one hour after percutaneous coronary intervention (post-percutaneous coronary intervention electrocardiogram) by an independent core laboratory. Complete ST-segment resolution was defined as ≥70% ST-segment resolution. Results: Complete ST-segment resolution occurred post-percutaneous coronary intervention in 54.9% ( n=800/1456) of patients and predicted lower 30-day composite major adverse cardiovascular and cerebrovascular events (odds ratio 0.35, 95% confidence interval 0.19–0.65; p<0.01), definite stent thrombosis (odds ratio 0.18, 95% confidence interval 0.02–0.88; p=0.03), and total mortality (odds ratio 0.43, 95% confidence interval 0.19–0.97; p=0.04). In multivariate analysis, independent negative predictors of complete ST-segment resolution were the time from symptoms to pre-hospital electrocardiogram (odds ratio 0.91, 95% confidence interval 0.85–0.98; p<0.01) and diabetes mellitus (odds ratio 0.6, 95% confidence interval 0.44–0.83; p<0.01); pre-hospital ticagrelor treatment showed a favorable trend for complete ST-segment resolution (odds ratio 1.22, 95% confidence interval 0.99–1.51; p=0.06). Conclusions: This study confirmed that post-percutaneous coronary intervention complete ST-segment resolution is a valid surrogate marker for cardiovascular clinical outcomes. In the current era of ST-elevation myocardial infarction reperfusion, patients’ delay and diabetes mellitus are independent predictors of poor reperfusion and need specific attention in the future.
Comparative efficacy and discontinuation of dimethyl fumarate and fingolimod in clinical practice at 24-month follow-up
Authors: Hersh Carrie M , Love Thomas E , Bandyopadhyay Anasua , Cohn Samuel , Hara-Cleaver Claire , Bermel Robert A , Fox Robert J , Cohen Jeffrey A , Ontaneda Daniel 
Published: August 2017

Background Dimethyl fumarate and fingolimod are oral disease-modifying therapies approved to treat relapsing multiple sclerosis. Prior observational studies and our previous 12-month investigation showed comparable clinical efficacy. Objective The purpose of this study was to assess real-world efficacy and discontinuation of dimethyl fumarate and fingolimod over 24 months in patients with multiple sclerosis. Methods Patients treated with dimethyl fumarate ( n = 395) or fingolimod ( n = 264) completed 24-month follow-up in a large academic multiple sclerosis center. Discontinuation rates and measures of disease activity were compared after propensity score weighting. The primary outcome was on-treatment annualized relapse rate ratio. Other measures included rate of drug discontinuation and brain magnetic resonance imaging activity defined as new T2 and/or gadolinium-enhancing lesions. Results Propensity score weighting showed excellent covariate balance. At 24 months, dimethyl fumarate demonstrated comparable annualized relapse rate (rate ratio = 1.45, 95% confidence interval 0.53–3.99) and brain magnetic resonance imaging activity (odds ratio = 1.38, 95% confidence interval 0.83–2.32). Dimethyl fumarate patients discontinued therapy earlier compared to fingolimod (hazard ratio = 1.40, 95% confidence interval 1.11–1.77) and were more likely to discontinue therapy due to intolerability (odds ratio = 1.98, 95% confidence interval 1.18–3.23). Conclusion Dimethyl fumarate and fingolimod had similar reductions in annualized relapse rate in clinical trials, and our real-world experience supports this observation. Dimethyl fumarate-treated patients had higher likelihood of early discontinuation, and this was mostly due to intolerability.
Fevipiprant, an oral prostaglandin DP2receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids
Authors: Bateman Eric D. , Guerreros Alfredo G. , Brockhaus Florian , Holzhauer Björn , Pethe Abhijit , Kay Richard A. , Townley Robert G. 
Published: August 2017

Dose-related efficacy and safety of fevipiprant (QAW039), an oral DP2(CRTh2) receptor antagonist, was assessed in patients with allergic asthma uncontrolled by low-dose inhaled corticosteroids (ICS).Adult patients were randomised to 12 weeks' treatment with once-daily (1, 3, 10, 30, 50, 75, 150, 300 or 450 mgq.d.) or twice-daily (2, 25, 75 or 150 mgb.i.d.) fevipiprant (n=782), montelukast 10 mgq.d. (n=139) or placebo (n=137). All patients received inhaled budesonide 200 μgb.i.d.Fevipiprant produced a statistically significant improvement in the primary end-point of change in pre-dose forced expiratory volume in 1 s at week 12 (p=0.0035) with a maximum model-averaged difference to placebo of 0.112 L. The most favourable pairwise comparisons to placebo were for the fevipiprant 150 mgq.d. and 75 mgb.i.d. groups, with no clinically meaningful differences betweenq.d. andb.i.d. Montelukast also demonstrated a significant improvement in this end-point. No impact on other efficacy end-points was observed. Adverse events were generally mild/moderate in severity, and were evenly distributed across doses and treatments.Fevipiprant appears to be efficacious and well-tolerated in this patient population, with an optimum total daily dose of 150 mg. Further investigations into the clinical role of fevipiprant in suitably designed phase III clinical trials are warranted.
The artists’ materials of P. S. Krøyer: An analytical study of the artist’s paintings and tube colours by Raman, SEM–EDS and HPLC
Authors: Christiansen Marie Bitsch , Baadsgaard Elizabeth , Sanyova Jana , Simonsen Kim Pilkjær 
Published: August 2017

Abstract
An analytical study of two paintings by P. S. Krøyer and the tube colours found in his painting cabinet has been carried out in order to investigate the artists’ materials used by Krøyer in the latter part of his oeuvre. The study has given a valuable knowledge about Krøyer’s choice of materials and their composition that may be helpful in e.g. preservation issues. The pigments and dyes were analysed by micro-Raman spectroscopy (MRS), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM–EDS), and high-performance liquid chromatography with diode-array detection (HPLC–DAD). The technical analyses were supplemented with archival studies of Danish nineteenth century paint shops. The results show that Krøyer used commercially available artists’ materials typical for that period in time. Being a wealthy artist, he seems to have favoured expensive pigments such as cobalt blue, viridian and cadmium yellow. Based on the analyses, the main development in Krøyer’s palette is the substitution of lead white with zinc white that appears to have taken place after 1886. The results also show that the contents of the tube colours in some cases differ from what was expected based on the trade names. This is particularly observed for the tube colours named “Oxide rouge” of which only one contains the expected hematite pigment, while all the remaining contain cadmium sulfide and natural organic red lakes. A rare tube colour named “Laque verte clair” was characterised to be mixture of Prussian blue and synthetic Indian yellow. The study therefore also illustrates that it was not always obvious to the artists what they bought from their colour merchant. It hence relates to existing international studies of nineteen century artists’ materials, which highlight the complexity of tube colours from this particular period in time.
RESUMOS DO VIII EDIÇÃO DO SIMPÓSIO IBEROAMERICANO DE PLANTAS MEDICINAIS E DO III SIMPÓSIO IBEROAMERICANO DE INVESTIGAÇÃO EM CÂNCER
Authors: CECHINEL FILHO Valdir , DE CAMPOS-BUZZID Fátima , A. RODRIGUES Clóvis , SAN FELICIANO Arturo 
Published: August 2017

Os eventos foram sediados pela Universidade do Vale do Itajaí (UNIVALI)e contou com o apoio e patrocínio do Programa CYTED (Programa Ibero-americano de Ciência e Tecnologia para o Desenvolvimento) por meio da Rede Iberoamericana de Estudos e Aproveitamento Sustentável da Biodiversidade Regional de Interesse Farmacêutico (RIBIOFAR/CYTED/CNPq) e da Rede Iberoamericana de Investigação em Câncer (RIBECANCER/CYTED/CNPq).
In vitro evaluation of cytotoxic, anti-proliferative, anti-oxidant, apoptotic, and anti-microbial activities of Cladonia pocillum
Authors: Ersoz M , Coskun Z. M. , Acikgoz B. , Karalti I. , Cobanoglu G. , Cesal C. 
Published: August 2017

The aim of this study was to investigate the anti-proliferative, apoptotic, cytotoxic, and anti-oxidant effects of extracts from the lichen Cladonia pocillumon human breast cancer cells (MCF-7), and to characterize the anti-microbial features. MCF-7 cells were treated with methanolic C. pocillum extract for 24h. The cytotoxicity of the extract was tested with MTT. Moreover, its anti-proliferative effects were examined with immunocytochemical method. Apoptosis and biochemical parameters were detected in MCF-7. The methanol and chloroform extracts of the lichen were tested for anti-microbial activity against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans using the disc diffusion method and calculation of minimal inhibitory concentrations. Although BrdU incorporation was not observed in MCF-7 cells treated with methanol extract at a concentration above 0.2 mg/mL, a significant decrease was observed int he percentage of PCNA immunoreactive cells in groups treated with 0.2, 0.4, 06, and 0.8 mg/mL methanol extracts of C.pocillum (49±6.3, 44±5.2, 23±2.5, 0, respectively) compared to that of control (85±4.5). The percentage of apoptotic cells significantly increased in groups treated with 0.2, 0.4, 0.6, and 0.8 mg/mL extracts of the C.pocillum (54±3.5, 76±2.6, 77±1.8, 82±4.2, respectively) compared with that of control group (3.9±1.5).The half-maximal inhibitory concentration of the methanol extract against MCF-7 cells was 0.802 mg/mL .Although the chloroform extract showed more effective anti-microbial activity overall, the methanol extract showed higher anti-fungal activity. Collectively, the results of our study indicate that C.pocillum extracts have strong anti-microbial and apoptotic effects. This lichen therefore shows potential for development as a natural anti-microbial, anti-oxidant, and apoptotic agent.
Synaptosomal and mitochondrial oxidative damage followed by behavioral impairments in streptozotocin induced diabetes mellitus: restoration by Malvastrum tricuspidatum
Authors: Solanki I. , Parihar P. , Shetty R. , Parihar M. S. 
Published: August 2017

Synaptosomal and mitochondrial impairments in the brain of diabetic individual manifest metabolic risk factors that most likely affect the brain functions. Diabetes is associated with the structural and functional alterations of the brain and neuronal loss leading to cognitive and other behavioral impairments, thus reducing the quality of life. The biochemical mechanisms underlying the diabetes-associated behavioral decline are poorly understood. In the present study, we examined the effects of hyperglycemia on the oxidative stress and behavioral functions in streptozotocin-induced diabetic mice. Our results showed the increase in oxidative stress in synaptosomes and brain mitochondria marked by an increase in lipid peroxidation and protein carbonyl content and decline in reduced glutathione in mice treated with streptozotocin. The oxidative damage in synaptosomes and brain mitochondria further caused impairment in locomotor and memory behavioral functions. Furthermore, we examined the protective effects of plant extract derived from Malvastrum tricuspidatum against STZ induced oxidative stress and behavioural impairments. For the first time we showed that this plant extract attenuate synaptosomal and mitochondrial oxidative stress and behavioral impairments in mice treated with streptozotocin. We suggest that streptozotocin caused impairments in synaptosomes and brain mitochondria and altered behavioral functions via increase in the oxidative stress and decrease in the antioxidant defense system. These impairments in synaptosomes and brain mitochondria and alterations in behavioral functions are significantly prevented by supplementation of Malvastrum tricuspidatum extract.
Effect of salinity on gene expression, morphological and biochemical characteristics of stevia rebaudiana Bertoni under in vitro conditions
Authors: Fallah F. , Nokhasi F. , Ghaheri M. , Kahrizi D. , Beheshti Ale Agha A. , Ghorbani T. , Kazemi E. , Ansarypour Z. 
Published: August 2017

Stevia rebaudiana Bertoni is a famous medicinal plant for its low calorific value compounds which are named steviol glycosides (SGs) and they are 150-300 times sweeter than sugar. Among various SGs, stevioside and rebaudioside A considered to be the main sweetening compounds. Soil salinity is one of the most essential stress in the world. Salinity affects the survival and yield of crops. In current study the effects of salinity and osmotic stress caused by different concentration of NaCl (0, 20, 40, 60 and 80 mM) on morphological traits, genes expressionand amount of both stevioside and rebaudioside Aunder in vitro conditions has been investigated. The morphological traits such as bud numbers, root numbers, shoot length (after 15 and 30 days) were evaluated. With increasing salinity, the values of all studied morphological traits decreased. To investigation of UGT74G1 and UGT76G1 genes expression that are involved in the synthesis of SGs, RT-PCR was done and there were significant differences between all media. The highest expression of both genes was observed in plantlets grown on MS media (with NaCl-free). Also, the lowest amounts of gene expression of the both genes were seen in MS+ 60 mM NaCl. Based on HPLC results, the highest amount of both stevioside and rebaudioside A were observed in plantlets grown in MS media (with NaCl-free). Finally, it can be concluded that stevia can survive under salt stress, but it has the best performance in the lower salinity.
Analysis of critical process parameters of ductile mode grinding of brittle materials
Authors: Faehnle Oliver , Doetz Marius , Dambon Olaf 
Published: August 2017

Abstract
The process of ductile mode grinding has been analyzed experimentally. Besides the traditional approach, controlling the depth of a cut on feed-controlled ultra-precision machines (UPMs), two alternative approaches have been tested. By applying fluid jet polishing (FJP) using a grinding slurry, a stable ductile mode grinding could be set up. Subsequently, loose abrasive grinding processes on load-controlled traditional spindle machines have been tested to be suited for ductile mode grinding identifying the dependence of crack initiation on the type of slurry fluid being applied. In that way, substantially improved levels of surface roughness could be achieved, although local brittle cracking within the generated clear apertures still remained. Furthermore, critical process parameters were identified determining the process window of feed-controlled ductile grinding applied on state-of-the-art UPM machineries. These have been analyzed experimentally, and it was found that the critical depth of a cut significantly depends on the set of critical process parameters being applied. Finally, the critical ductile grinding process parameters could be identified determining the generated level of surface roughness achieving 0.83 nm Ra on tungsten carbide.