bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amaurosis fugax due to internal carotid artery dissection during carotid chemodectoma resection
Authors: Akhmedov A.D. , Lukshin V.A. , Shmigelsky A.V. , Kurbasov A.A. , Usachev D.Yu. 
Published: October 2024

The article presents a clinical observation of carotid chemodectoma resection, which was complicated by amaurosis fugax and left-sided hemianopia due to dissection of internal carotid artery during surgery. The clinical symptoms manifested on 3rd day after surgery and totally resolved after internal carotid artery reconstruction also on the 3rd day. Treatment of carotid chemodectoma requires a multidisciplinary approach involving a neurosurgeon who has the skills of reconstructive operations on brachiocephalic arteries, a radiologist, and an endovascular surgeon. Determining the tactics and stages of treatment requires an individual approach, depending on the size of the tumor, the degree of invasion into the carotid arteries and cranial nerves.
В данной статье приводится описание клинического наблюдения удаления каротидной хемодектомы, ослож- нившейся развитием преходящего амавроза со стороны операции и левосторонней гемианопсии. Данное осложнение стало следствием диссекции внутренней сонной артерии (ВСА) после удаления опухоли с мани- фестацией клинических симптомов на 3-и сутки после операции. У пациента острота зрения восстановилась на 1-е сутки после операции до 1,0, гемианопсия регрессировала на 3-и сутки после реконструкции ВСА. Лечение каротидных хемодектом требует полидисциплинарного подхода с участием нейрохирурга, владею- щего навыками реконструктивных операций на брахиоцефальных артериях, радиолога, эндоваскулярного хирурга. Определение тактики и этапности лечения требует индивидуального подхода в зависимости от размеров опухоли, степени инвазии в сонные артерии и черепные нервы.
hanges in the structure of the sodium-potassium pumpin different parts of the rat brain after administration of the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxin
Authors: Korolev A.G. , Kiseleva N.M. , Inozemtsev A.N. 
Published: October 2024

The variety of non-motor symptoms at the preclinical stage of Parkinson's disease makes it relevant to search for adequate and simple methods for their modeling in rodents. Subcutaneous or intraperitoneal administration of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to mice is one of the most common models of experimental parkinsonism in rodents. Intranasal administration of this neurotoxin to rats remains a less studied but promising way to induce moderate damage to brain dopaminergic neurons without causing motor symptoms in animals. Material and methods. MPTP was administered intranasally to 28 Wistar rats. After 16 days, 9 brain structures were extracted and the content of three α-subunits of Na/K-ATPase was evaluated by Western Blotting.Results. We found that a single intranasal administration of neurotoxin to rats led to a decrease in the content of α1- and α2-subunits and an increase in the content of α3-subunits of Na/K-ATPase in various parts of the rat cerebral cortex, including the olfactory bulbs. In subcortical structures, changes were found only in the striatum and hippocampus. Conclusions. The obtained data suggest a change in the functional activity of brain neurons in the structures associated with the acquisition and execution of instrumental reflexes in rats
Многообразие немоторных нарушений болезни Паркинсона на доклинической стадии развития заболевания делает актуальным поиск адекватных и простых способов их моделирования на грызунах. Подкожное или внутрибрюшинное введение нейротоксина 1-метил-4- фенил-1,2,3,6-тетрагидропиридина (МФТП) мышам является одной из наиболее распространенных моделей экспериментального паркинсо- низма на грызунах. Интраназальное введение данного нейротксина крысам остается менее изученным, но перспективным способом вызвать у животных умеренное повреждение дофаминергических нейронов головного мозга без моторной симптоматики. Материал и методы. МФТП вводили интраназально 28 крысам Wistar. Через 16 дней извлекали 9 структур головного мозга и методом Вестерн–Блоттинга оценивали содержание трех α-субъединиц Na/K-АТФазы. Результаты. Установлено, что однократное интраназальное введение нейротоксина крысам привело к снижению содержания α1- и α2- субъедениц и росту числа α3-субъедениц Na/K-ATФазы в различных отделах коры головного мозга крыс, в т.ч. в обонятельных луковицах. В подкорковых структурах изменения были выявлены только в стриатуме и гиппокампе. Выводы. Полученные данные позволяют предположить изменение функциональной активности нейронов го- ловного мозга в структурах, связанных с выработкой и воспроизведением инструментальных рефлексов у крыс.
Pengembangan Ensiklopedia Digital pada Pelajaran Ekosistem Berbasis Kurikulum Merdeka
Authors: Tristiyono Dicky , Carolina Hifni Septina 
Published: October 2024

Ensiklopedia adalah media belajar yang memuat informasi, definisi, serta terdapat gambar dan video yang menarik. Hal ini sesuai dengan kurikulum merdeka yang memiliki karakteristik mengikuti gaya belajar siswa. Penelitian ini bertujuan untuk (1) Mengembangkan media pembelajaran ensiklopedia pada pelajaran ekosistem berbasis kurikulum merdeka. (2) Menganalisis kelayakan media pembelajaran ensiklopedia pada pelajaran ekosistem berbasis kurikulum merdeka. (3) Mengetahui respons guru dan siswa terhadap pengembangan ensiklopedia digital pada pelajaran ekosistem berbasis kurikulum merdeka. Penelitian ini menggunakan metode research and development (R&D) dengan menggunakan model pengembangan ADDIE yang terdiri dari lima tahap yaitu Analysis, Design, Development, Implementation, dan Evaluation. Hasil penelitian adalah produk pembelajaran dalam bentuk Ensiklopedia digital yang telah melalui validasi oleh ahli materi dan ahli media serta uji coba dari respons guru dan respons siswa. Evaluasi persentase menunjukan bahwa ensiklopedia ini tergolong “sangat baik”, sehingga dapat digunakan sebagai media pembelajaran.
Histiocitosis de células de Langerhans: una actualización basada en un caso real. Parte 2
Authors: Zavala-Mena Mario , Jimeno-Ortega Isabel , Aedo-Inostroza Gabriel 
Published: October 2024

Las histiocitosis son trastornos raros caracterizados por la acumulación de células dendríticas o macrófagos en diversos órganos, con predilección por piel y hueso (1). Su comportamiento clínico varía desde formas leves hasta potencialmente mortales (2). La primera clasificación de histiocitosis de 1987 (3) constaba de 3 categorías: Células de Langerhans (HCL), no relacionadas con LC (HCNL) e histiocitosis malignas (HM). Estas neoplasias inflamatorias pueden presentarse en formas limitadas, difusas o con compromiso multiorgánico (4), manifestándose de múltiples maneras e imitando a otras enfermedades, por lo que representan un desafío diagnóstico para la clínica.
Effects of Nesting Material and Housing Parameters on Feed Wastage Behavior in Female Swiss Webster Mice
Authors: Zawacki Zosia E , Sharpe James A , Porco Travis C , Lindstrom Krista E 
Published: October 2024

AbstractFeed wastage in laboratory mice, also known as chewing or grinding behavior, is problematic for program management and animal welfare. The destruction of pelleted feed without consumption produces a powder accumulation on the cage floor called orts. Ort accumulation disrupts the cage microenvironment and can clog Lixits resulting in flooding. Moreover, added labor adds cost, and cage disruption increases animal stress. Published studies examining the behavior and ways to mitigate it have had inconsistent results, and the cause or causes have not yet been fully identified. The purpose of this study was to identify methods to reduce the development of chewing behavior in laboratory mice. Female Swiss Webster (Tac:SW) mice (n = 144) were randomly assigned to one of 8 groups (12 cages per group) with 2 housing densities (single and pair) and 4 nesting material paradigms. Mice were housed on clean bedding for 8 wk and then soiled bedding for the next 8 wk. Chewing behavior was evaluated by feed weight, cage weight, and feed scores. The addition of a Diamond Twist significantly increased ort production, while nest transfer decreased it but not significantly. Pair housing increased overall orts but not when adjusted for animal number. These results identified potential contributing factors to chewing behavior. However, further research is needed to elucidate the exact causes and solutions.
Pharmacokinetics of Extended-Release Buprenorphine and Clinical Efficacy for Postoperative Pain Management in the Domestic Ferret (Mustela putorius furo)
Authors: Plunkard Jessica C M , Jimenez Isabel A , Tarwater Patrick M , Craney Morgan C , Villano Jason S 
Published: October 2024

AbstractBuprenorphine hydrochloride (Bup-HCl) is a common injectable opioid analgesic. In ferrets, Bup-HCl must be administered every 8 to 12 h to maintain clinical efficacy. Extended-release analgesics offer multiple advantages, including reduced handling and injection frequency, improved compliance, and increased protection from end-of-dose failure. Although efficacy of extended-release buprenorphine formulations has been demonstrated in other species, their use in the domestic ferret has not been investigated. In this study, we evaluated the pharmacokinetics of a compounded polymeric formulation of buprenorphine (Bup-ER) and a pharmaceutical-grade, FDA-indexed liposomal suspension (Bup-XR). Two doses each of Bup-ER (0.12 and 0.2 mg/kg) and Bup-XR (0.2 and 0.6 mg/kg SC) were administered to young adult female ferrets and plasma concentrations were measured between 0 and 96 h (n = 4 animals per timepoint). All doses of both drugs achieved therapeutic plasma levels by 30 min. Furthermore, high-dose Bup-XR maintained therapeutic levels for 72 h, followed by high-dose Bup-ER (less than 48 h), low-dose Bup-XR (24 h), and low-dose Bup-ER (less than 24 h). In this study, we also developed a pain scoring system and utilized this to compare analgesic efficacy between single high-dose Bup-XR (0.6 mg/kg SC) and a standard postoperative course of Bup-HCl (0.02 mg/kg SC every 10 to 12 h for 8 doses) after ovariohysterectomy. Ferrets receiving Bup-XR had significantly lower respiratory rate and posture scores in the first 24 h postoperatively than did those that received Bup-HCl and were less likely to react to palpation of the surgical incision. Of note, ferrets that received high-dose Bup-ER had a significantly higher incidence of injection site reactions than ferrets that received Bup-HCl (P = 0.0137). This study demonstrates that a single dose of Bup-XR (0.6 mg/kg SC) is a safe and effective analgesic in female ferrets, with a duration of action up to 72 h and minimal side effects, offering a refinement to analgesia in this species.
How Listening YouTube Song Habit Influences Students’ Vocabulary Mastery: A Correlational Study
Authors: Abudi Oxa Oktaviana , Hasan Jhems Richard , Helingo Adimawati 
Published: October 2024

Vocabulary mastery is essential for students to be able to communicate well in English. However, some students still struggle memorizing new words and identifying vocabulary meanings. This study aims to determine the correlation between students' habits of listening to English YouTube songs and their vocabulary mastery. The research used a quantitative correlational approach involving 24 tenth-grade students at SMA N 1 SUWAWA. The data collection was done using a questionnaire about listening habits to English songs and a vocabulary test. The data analysis was performed using the Pearson Product Moment formula. The result showed that there is a moderate positive correlation between the habit of listening to English YouTube songs and the mastery of vocabulary of SMA N 1 Suwawa tenth-grade students (r = 0.529). This indicates that the more intense the students' habit of listening to English YouTube songs, the better their vocabulary mastery. Listening habit contributes 27.98% to the mastery of vocabulary. Based on these results, it can be concluded that there is a moderate correlation between listening habit to English YouTube songs and vocabulary mastery of tenth grade students at SMA N 1 Suwawa. The more students listen to English songs, the better they master vocabulary.Keywords: listening Habit, YouTube song, vocabulary mastery
Análisis de narrativas periodísticas sobre protestas de personas mayores en Venezuela
Authors: Manjarrés Ramos Elízabeth 
Published: October 2024

Introducción: La crisis económica y política en Venezuela, intensificada desde 2013, ha aumentado significativamente las protestas sociales. Los adultos mayores han sido uno de los grupos más afectados y han organizado manifestaciones en reclamo de una vida digna. Este estudio analizó la cobertura del diario El Universal sobre estas protestas entre marzo de 2018 y mayo de 2024, examinando las representaciones de los adultos mayores en sus publicaciones. Metodología: Tras una búsqueda hemerográfica, se realizó un análisis cualitativo desde los estudios críticos del discurso de las publicaciones sobre protestas de mayores en El Universal, evaluando tanto los discursos escritos como las fotografías. Resultados y discusión: Se identificaron cuarenta y tres (43) titulares y treinta y cinco (35) imágenes al respecto. Las representaciones destacan a los mayores como protagonistas de movimientos sociales y agentes políticos, promoviendo nuevos modelos de vejez. Sin embargo, persisten imágenes edadistas que subrayan la fragilidad de los adultos mayores. La cobertura informativa es limitada, no refleja la diversidad del grupo y las mujeres están subrepresentadas. Conclusión: A la luz de estos resultados, se considera necesario reflejar una mayor diversidad en los medios de comunicación para contrarrestar estereotipos y promover la igualdad y el activismo entre mayores.
Detection of Pb(II) and Cr(III) Using Dy(III) Ion with Pyrazoline Derivatives Ligand
Authors: Syahputri Yulian , Sutanto  , M. Daud Mahmudin  , Mohammad Rommy Izha Ramadhan  
Published: October 2024

Exposure to heavy metal ions Pb2+ and Cr3+ in Indonesia is getting more attention, especially in various industries and transportation. The sensor complex compound Dy3+ with fluorescence-based pyrazoline-derived ligands (fluorosensor) has the potential to detect heavy metal ions Pb2+ and Cr2+. This research was initiated by synthesizing the pyrazoline derivative ligand and then reacting it with Dy3+ metal ion. The formed Dy3+ complex compounds was then characterized using spectroscopic methods. The results of scanning complex compounds using a UV-Vis spectrophotometer obtained two maximum wavelengths namely at 255 and 359 nm are indicating the presence of a transition type n→π* and π→π*. The results of fluorescence spectrophotometer analysis obtained maximum fluorescence intensity of Dy3+ complex compound was in the wavelength at 370 nm with fluorescence intensity of 4273 a.u. Fluorescence based sensor studies of the Dy complex when Pb2+ and Cr3+ metal ions were added showed changes in fluorescence intensity so that the fluorosensor type was obtained for the Dy3+ metal ion complex compound with Pb2+ and Cr3+, namely "turn-on-off" and "turn-off" respectively.
Is It Just Dumb Luck? The Challenge of Getting Access to Public Records Related to Smart City Technology
Authors: Sanders Amy Kristin , Stewart Daxton "Chip" , Molchanov Steven 
Published: October 2024

Many state and local governments have begun to rely heavily on Smart City technologies, including license plate readers, gun-shot detection equipment, wastewater monitoring tools, and more. But the public often has little oversight with regard to their purchase, installation, and use. We analyze public records laws and relevant case law to examine whether the laws provide access to records about, and produced by, Smart City technologies. Even in states that broadly define “public record,” officials regularly rely on exemptions—often citing law enforcement or privacy concerns—to deny access. Further, many Smart City technologies have not been addressed by the legislatures and courts, but legislation and litigation involving two technologies (police body-worn cameras and police dash cameras) have advanced—offering some optimism.
Development and evaluation of a new winter bread wheat variety Rubin Dona according to the main economically valuable traits
Authors: Samofalov A. P. , Podgorny S. V. , Skripka O. V. , Chernova V. L. , Kravchenko N. S. 
Published: October 2024

Relevance. The development of new varieties and their rapid introduction into production remains the most effective resource for improving productivity, energy saving, profitability and competitiveness. The purpose of the current study was to develop the winter bread wheat variety Rubin Dona and evaluate its productivity and basic adaptive, technological, and baking properties.Methods. The current study was carried out in the fields of research crop rotation of the department of winter wheat breeding and seed production in 2018–2023. The variety was developed by the method of intravarietal hybridization using the productive and adaptive variety Nakhodka as a maternal form and the high-quality strong wheat variety Donskaya Yubileynaya as a paternal form and a subsequent individual selection.Results. There has been established that the variety Rubin Dona has a high and stable level of productivity. For 6 years of competitive variety testing the mean productivity of the variety sown in green manure fallow was 9.45 t/ha with the minimum of 6.77 t/ha and the maximum of 11.80 t/ha, compared to the standard variety Ermak with 8.80, 6.06 and 11.21 t/ha, respectively. The variety Rubin Dona sown after various forecrops also demonstrates a reliable and stable productivity increase to the standard, 0.67 t/ha after maize for grain, 0.79 t/ha after peas, 0.62 t/ha after sunflower, 0.77 t/ha after winter wheat. There has been revealed that the advantage of the new variety, which provides high and stable yields, is its high environmental resistance to regional soil and climatic conditions such as drought, low temperatures, spring frosts, diseases, and lodging. The variety has lower indicators of the coefficient of variation, factor of stability (FS), yield range (d) with a high level of realization of productivity potential in comparison with both the standard variety Ermak and the highly productive variety Razdolie, which has a contrasting periods of heading and ripening. The technological and baking properties of the new variety are of high quality and meet the requirements of GOST-9353-2016 referring to the first class. Since 2023, by decision of the State Commission of the Russian Federation for testing and protection of breeding achievements, the variety has been included in the State List of the varieties approved for use in the Central Blackearth (5) and Lower Volga (8) regions.
Síndrome de Ovario Poliquístico y Salud Mental en Adolescentes
Authors: Matte María Rosario , Del Rio Juan Pablo , Fernández Olga , Crisosto King Nicolás 
Published: October 2024

El Síndrome de Ovario Poliquístico (SOP) es el desorden endocrino-metabólico más frecuente en las adolescentes. Se asocia a complicaciones metabólicas, cardiovasculares y reproductivas. Hallazgos recientes sugieren también una asociación con patología psiquiátrica, tanto en las pacientes afectadas como en su descendencia. En la presente actualización, se realizó una síntesis de la literatura reciente relativa a la salud mental en mujeres y adolescentes con SOP. Se realizó una búsqueda sistematizada en PubMed, Epistemonikos y Scielo de los artículos publicados en los últimos 5 años. Se confirmó que existe un aumento significativo del riesgo de presentar trastornos por ansiedad, depresión, trastornos alimenticios, trastorno obsesivo compulsivo, trastorno afectivo bipolar y psicosis en mujeres con SOP. Además, presentan riesgo de trastornos del neurodesarrollo, tales como trastorno del espectro autista y trastorno por déficit atencional e hiperactividad, tanto en ellas como en su descendencia. La hiperinsulinemia y el hiperandrogenismo podrían explicar parte de estas asociaciones, afectando la maduración del sistema nervioso central, especialmente durante la vida intrauterina y la adolescencia. El distrés derivado de las características fenotípicas físicas de la enfermedad también podría impactar la salud mental de las pacientes. Aún no se cuenta con suficientes estudios que expliquen el origen de esta correlación, ni tampoco con ensayos clínicos que aborden la salud mental de forma específica en estas pacientes. La evidencia actual sugiere la necesidad de evaluar activamente la salud mental de estas pacientes y coordinar a los distintos equipos de salud que intervengan en el manejo de la patología.
Faktor-Faktor yang Memengaruhi Keberhasilan Terapi Kompresi Terhadap Perbaikan Ulkus Vena Tungkai Kronik
Authors: Miguna Landry , Jason Daniel , Gunadi Julia Windi , Sanjaya Ardo , Gunawan Decky 
Published: October 2024

Ulkus vena tungkai masih merupakan masalah kesehatan yang serius karena kondisi ini masih sulit disembuhkan, seringkali menjadi kronik, dan menurunkan kualitas hidup penderitanya. Meskipun mekanisme kerja pastinya belum jelas, saat ini terapi kompresi masih menjadi pilihan utama terapi karena terbukti menurunkan angka rekurensi. Terapi kompresi memiliki variasi dalam jenis, durasi, dan tekanan yang dihasilkan. Literature review ini bertujuan untuk mengevaluasi lebih dalam tentang faktor-faktor yang memengaruhi keberhasilan terapi kompresi terhadap perbaikan ulkus vena tungkai kronik. Metode dilakukan dengan pencarian artikel dari search engine Pubmed, Google Scholar dengan kata kunci 'venous ulcer', 'compression therapy', 'chronic leg ulcer', 'pressure of compression', 'stocking compression' dan kombinasinya yang dipublikasikan dalam 20 tahun terakhir. Faktor-faktor kompresi yang diteliti yaitu jenis kompresi, durasi kompresi, dan tekanan kompresi. Indikator perbaikan yang diteliti yaitu gejala dan kondisi klinis, angka rekurensi, dan perbaikan kualitas hidup. Hasil dari 7 artikel yang ditelaah menunjukan bahwa terapi kompresi aman dan efektif di dalam mencegah rekurensi ulkus tungkai, mengurangi keluhan, dan memperbaiki kualitas hidup. Tidak ada pengaruh dari jenis dan durasi terapi kompresi terhadap keberhasilan. Derajat tekanan kompresi memengaruhi angka rekurensi, khususnya pada pengguna stoking kompresi. Sebagai simpulan, keberhasilan terapi kompresi terhadap perbaikan ulkus vena tungkai kronik terutama dipengaruhi oleh tingkat kepatuhan pasien dalam menjalani terapi yang memerlukan waktu jangka panjang.
Hubungan Lama Menderita dan Jenis Bangkitan dengan Memori Jangka Pendek pada Penderita Epilepsi di RS Pertamina Bintang Amin Bandar Lampung
Authors: Agustina Sifa , Sina Muhammad Ibnu , Fitriani Dita , Amroisa RA Neilan 
Published: October 2024

Gangguan kognitif pada epilepsi disebabkan oleh beberapa faktor yaitu usia onset, jenis bangkitan, frekuensi kejang, lamanya menderita epilepsi, etiologi kejang, serta efek samping dari penggunaan Obat Anti Epilepsi (OAE). Salah satu fungsi kognitif adalah fungsi memori atau daya ingat. Memori jangka pendek adalah informasi yang bertahan beberapa menit, umumnya >30 detik. Tujuan penelitian ini adalah untuk mengetahui hubungan antara lama menderita dan jenis bangkitan dengan memori jangka pendek pada penderita epilepsi. Penelitian ini merupakan penelitian analitik observasional dengan desain penelitian cross sectional. Data diambil dengan melihat rekam medik dan melakukan pemeriksaan uji digit span pada pasien. Populasi penelitian ini adalah pasien epilepsi yang berobat di Poliklinik Rawat Jalan Neurologi RS Pertamina Bintang Amin Bandar Lampung. Teknik pengambilan sampel yang digunakan adalah consequtive sampling dengan jumlah sampel sebanyak 73 pasien. Analisis statistik yang digunakan adalah uji chi square. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara lama menderita epilepsi dan jenis bangkitan dengan memori jangka pendek pada penderita epilepsi.