bluuebunny/crossref_metadata_2025_split huggingface dataset:
BMI was found to be a consistent determinant related to misreporting of energy, protein and potassium intake using self-report and duplicate portion methods
Authors: Trijsburg Laura , Geelen Anouk , Hollman Peter CH , Hulshof Paul JM , Feskens Edith JM , van’t Veer Pieter , Boshuizen Hendriek C , de Vries Jeanne HM 
Published: October 2016

AbstractObjectiveAs misreporting, mostly under-reporting, of dietary intake is a generally known problem in nutritional research, we aimed to analyse the association between selected determinants and the extent of misreporting by the duplicate portion method (DP), 24 h recall (24hR) and FFQ by linear regression analysis using the biomarker values as unbiased estimates.DesignFor each individual, two DP, two 24hR, two FFQ and two 24 h urinary biomarkers were collected within 1·5 years. Also, for sixty-nine individuals one or two doubly labelled water measurements were obtained. The associations of basic determinants (BMI, gender, age and level of education) with misreporting of energy, protein and K intake of the DP, 24hR and FFQ were evaluated using linear regression analysis. Additionally, associations between other determinants, such as physical activity and smoking habits, and misreporting were investigated.SettingThe Netherlands.SubjectsOne hundred and ninety-seven individuals aged 20–70 years.ResultsHigher BMI was associated with under-reporting of dietary intake assessed by the different dietary assessment methods for energy, protein and K, except for K by DP. Men tended to under-report protein by the DP, FFQ and 24hR, and persons of older age under-reported K but only by the 24hR and FFQ. When adjusted for the basic determinants, the other determinants did not show a consistent association with misreporting of energy or nutrients and by the different dietary assessment methods.ConclusionsAs BMI was the only consistent determinant of misreporting, we conclude that BMI should always be taken into account when assessing and correcting dietary intake.
Chinese abolitionism: the Chinese Educational Mission in Connecticut, Cuba, and Peru
Authors: Rimner Steffen 
Published: October 2016

AbstractThis article explores a little known facet of transnational opposition to forced labour through the earliest case of ‘Chinese abolitionism’. It analyses the transnational formation of the first Sino-American actor network in the United States and its deployment in the 1874 investigations of coolie conditions in the forced labour regimes of Cuba and Peru. At the core of this actor network was the Chinese Educational Mission and its milieu of sociability, which served as a crucible of transnational cooperation between the first Chinese America experts and their US supporters. The flows of information, cosmopolitan ideas, and personnel across this network led to an unprecedented reinterpretation of the global coolie trade as a key concern in Qing foreign relations and a serious international problem that paralleled the problem of slavery. Two Qing interventions harnessed the actor network’s social capital, framing coolie abuse as an international atrocity, accelerating the abolition of the coolie trade, and signalling the need for a Chinese Foreign Service in Western countries for the protection of Chinese overseas.
Catholic nuns in transnational mission, 1528–2015
Authors: O’Brien Anne 
Published: October 2016

AbstractFrom the Counter-Reformation to the present, women in a variety of contexts of colonization, decolonization, and slavery crossed the threshold from missionary congregation to missionary workforce to live in Catholic religious community. Comparative, transnational analysis provides insights from a variety of angles into the myriad local factors that fashioned their understandings of the relationship between the spiritual and material benefits so gained. Their experiences were uneven, shaped by the race, gender, and status politics of each ecclesiastical and secular context, by their usefulness to the wider missionary project and the state, and by shifts in ecclesiastical rulings that were prompted by changes in the Vatican’s temporal status. In the later twentieth century, some became activists and advocates, using their symbolic power to work in the interests of women and poor people, and to reform the patriarchy at the core of the church.
Circuits of wealth, circuits of sorrow: financing the illegal transatlantic slave trade in the age of suppression, 1850–66
Authors: Harris John A. E. 
Published: October 2016

AbstractSlave traders forced more than 1.65 million captive Africans aboard illegal transatlantic slave ships during the nineteenth century. This article focuses on the final phase of this brutal traffic, between 1850 and 1866. It argues that slave traders sustained their illicit industry, in large part, by strategically coordinating their financial arrangements against a rising tide of international suppression. One key tactic was for slave trade investors in the United States, Cuba, Africa, and Iberia to lower the risks of interdiction by joining forces and co-financing voyages. Another was to combine with an international cast of merchants and bankers, who helped them launder slave trade capital and transmit it to their distant allies. This capital was concealed within broader currents of global commerce, which was, in turn, spurred by the growth of free trade in the nineteenth century. These myriad alliances and capital flows undergirded the trade until its final extinction in the 1860s.
Mortality forecasting using a modified CMI Mortality Projections Model for China II: cities, towns and counties
Authors: Huang Fei 
Published: October 2016

AbstractIn this paper, we conduct the study of long-term age-sex-specific mortality forecasting for subpopulations in different areas of China: cities, towns and counties. We use a modified CMI (Continuous Mortality Investigation) Mortality Projections Model, which has been discussed in Huang & Browne (Paper I), for modelling purposes. From the historical experience, we find that people in cities have lower mortality rates and higher mortality improvement rates than people in towns and counties for most ages. If this trend continues, the mortality of different areas will diverge further in the future. From the projection results, we find that there will be significant mortality and life expectancy differences between cities, towns and counties for both males and females. Sensitivity analysis for long-term rates of mortality improvement and the speed of convergence from “initial” to “long-term” rates of mortality improvement are conducted. Uncertainties are attached to the central estimates to overcome the limitation of the original CMI approach from which only deterministic results can be obtained.
Psychometric Properties of the Attitudinal Beliefs Questionnaire about Suicidal Behavior (CCCS-18)
Authors: Villacieros Marta , Bermejo José Carlos , Magaña Marisa , Fernández-Quijano Invención 
Published: October 2016

AbstractThe purpose of this study was to analyze psychometric properties of the Spanish version of Attitudinal Beliefs Questionnaire about Suicidal Behavior CCCS-18 (Ruiz, Navarro-Ruiz, Torrente, & Rodríguez, 2005). The participants were 277 subjects, 81.2% (225) women and 18.8% (52) men. The average age was 39.95 years old (SD= 15.9). A confirmatory factor analysis was performed to test the adequacy of the four-factor model proposed by the authors. As a result it was obtained a three-factor model (χ2/df= 1.96;CFI= .98;sRMR= .060;RMSEA= .059), with indices reflecting adequate goodness of fit. The reliability of the test using theomega coefficientshowed satisfactory values (ωh= .95, CI 95% = [.94, .96]). The results indicate a close relation between the CCCS-18 dimensions and the suicidal tendency, showing discriminant validity properties. Predictive validity was also found in the significant correlations between the measures obtained in the questionnaire and a risk index resulting from the suicidal ideation predictor variables that were part of a logistic regression equation; CCCS-18 (r= .26,p< .001), F1,Legimization and terminal disease(r= .163,p< .01), F2,Moral dimension(r= .22,p< .001) and F3,Suicide itself(r= .252,p< .001). Conclusions: The CCCS-18 shows reliability and validity, as well as being a test of easy and brief application.
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
Authors: Kivelä Riikka , Salmela Ida , Nguyen Yen Hoang , Petrova Tatiana V. , Koistinen Heikki A. , Wiener Zoltan , Alitalo Kari 
Published: October 2016

AbstractThe remarkable adaptive and regenerative capacity of skeletal muscle is regulated by several transcription factors and pathways. Here we show that the transcription factor Prox1 is an important regulator of myoblast differentiation and of slow muscle fibre type. In both rodent and human skeletal muscles Prox1 is specifically expressed in slow muscle fibres and in muscle stem cells called satellite cells. Prox1 activates the NFAT signalling pathway and is necessary and sufficient for the maintenance of the gene program of slow muscle fibre type. Using lineage-tracing we show that Prox1-positive satellite cells differentiate into muscle fibres. Furthermore, we provide evidence that Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1. These results identify Prox1 as an essential transcription factor that regulates skeletal muscle phenotype and myoblast differentiation by interacting with the NFAT and Notch pathways.
Role of the pH in state-dependent blockade of hERG currents
Authors: Wang Yibo , Guo Jiqing , Perissinotti Laura L. , Lees-Miller James , Teng Guoqi , Durdagi Serdar , Duff Henry J. , Noskov Sergei Yu. 
Published: October 2016

AbstractMutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. In this study, molecular simulations of dofetilide binding to the previously developed and experimentally validated models of the hERG channel in open and open-inactivated states were combined with voltage-clamp experiments to unravel the mechanism(s) of state-dependent blockade. The computations of the free energy profiles associated with the drug block to its binding pocket in the intra-cavitary site display startling differences in the open and open-inactivated states of the channel. It was also found that drug ionization may play a crucial role in preferential targeting to the open-inactivated state of the pore domain. pH-dependent hERG blockade by dofetilie was studied with patch-clamp recordings. The results show that low pH increases the extent and speed of drug-induced block. Both experimental and computational findings indicate that binding to the open-inactivated state is of key importance to our understanding of the dofetilide’s mode of action.
DNA methyltransferases and stress-related genes expression in zebrafish larvae after exposure to heat and copper during reprogramming of DNA methylation
Authors: Dorts Jennifer , Falisse Elodie , Schoofs Emilie , Flamion Enora , Kestemont Patrick , Silvestre Frédéric 
Published: October 2016

AbstractDNA methylation, a well-studied epigenetic mark, is important for gene regulation in adulthood and for development. Using genetic and epigenetic approaches, the present study aimed at evaluating the effects of heat stress and copper exposure during zebrafish early embryogenesis when patterns of DNA methylation are being established, a process called reprogramming. Embryos were exposed to 325 μg Cu/L from fertilization (<1 h post fertilization - hpf) to 4 hpf at either 26.5 °C or 34 °C, followed by incubation in clean water at 26.5 °C till 96 hpf. Significant increased mortality rates and delayed hatching were observed following exposure to combined high temperature and Cu. Secondly, both stressors, alone or in combination, significantly upregulated the expression of de novo DNA methyltransferase genes (dnmt3) along with no differences in global cytosine methylation level. Finally, Cu exposure significantly increased the expression of metallothionein (mt2) and heat shock protein (hsp70), the latter being also increased following exposure to high temperature. These results highlighted the sensitivity of early embryogenesis and more precisely of the reprogramming period to environmental challenges, in a realistic situation of combined stressors.
Assessment of regional air quality by a concentration-dependent Pollution Permeation Index
Authors: Liang Chun-Sheng , Liu Huan , He Ke-Bin , Ma Yong-Liang 
Published: October 2016

AbstractAlthough air quality monitoring networks have been greatly improved, interpreting their expanding data in both simple and efficient ways remains challenging. Therefore, needed are new analytical methods. We developed such a method based on the comparison of pollutant concentrations between target and circum areas (circum comparison for short), and tested its applications by assessing the air pollution in Jing-Jin-Ji, Yangtze River Delta, Pearl River Delta and Cheng-Yu, China during 2015. We found the circum comparison can instantly judge whether a city is a pollution permeation donor or a pollution permeation receptor by a Pollution Permeation Index (PPI). Furthermore, a PPI-related estimated concentration (original concentration plus halved average concentration difference) can be used to identify some overestimations and underestimations. Besides, it can help explain pollution process (e.g., Beijing’s PM2.5 maybe largely promoted by non-local SO2) though not aiming at it. Moreover, it is applicable to any region, easy-to-handle, and able to boost more new analytical methods. These advantages, despite its disadvantages in considering the whole process jointly influenced by complex physical and chemical factors, demonstrate that the PPI based circum comparison can be efficiently used in assessing air pollution by yielding instructive results, without the absolute need for complex operations.
TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells
Authors: Tseng Hisa Hui Ling , Vong Chi Teng , Kwan Yiu Wa , Lee Simon Ming-Yuen , Hoi Maggie Pui Man 
Published: October 2016

AbstractExcessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1β (IL-1β), which contributes to the pathogenesis of diabetes and its complications. Although high glucose (HG)-induced oxidative stress and aberrant Ca2+ channels activity causes an increase in transmembrane Ca2+ influx, however the relative contribution of Transient receptor potential (TRP) channels is not well studied. Here, we identified that HG (30 mM glucose for 48 h) induced the activation of the NLRP3-ASC inflammasome, leading to caspase-1 activation, and IL-1β and IL-18 secretion in human monocytic cell lines. Moreover, we used a hyperglycemia model in U937 monocytes, showing that the activation of TRPM2 was augmented, and TRPM2-mediated Ca2+ influx was critical for NLRP3 inflammasome activation. This pathway involved NADPH oxidase-dependent ROS production and TXNIP-NLRP3 inflammasome pathway. Furthermore, the inhibition of TRPM2 reduced ROS production and lowered NADPH oxidase activity via cooperatively interaction with p47 phox in response to HG. These results provided a mechanistic linking between TRPM2-mediated Ca2+ influx and p47 phox signaling to induce excess ROS production and TXNIP-mediated NLRP3 inflammasome activation under HG, and suggested that TRPM2 represented a potential target for alleviating NLRP3 inflammasome activation related to hyperglycemia-induced oxidative stress in Type 2 diabetes Mellitus (T2DM).
A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs
Authors: Duffier Yoann , Lorthiois Audrey , Cisteró Pau , Dupuy Florian , Jouvion Grégory , Fiette Laurence , Mazier Dominique , Mayor Alfredo , Lavazec Catherine , Moreno Sabater Alicia 
Published: October 2016

AbstractThe development of new drugs to disrupt malaria transmission requires the establishment of an in vivo model to address the biology of Plasmodium falciparum sexual stages (gametocytes). Herein we show that chemically immune-modulated NSG mice grafted with human erythrocytes support complete sexual development of P. falciparum parasites and generate high gametocytemia. Immunohistochemistry and RT-qPCR analyses indicate an enrichment of immature gametocytes in the bone marrow and the spleen, suggesting a sequestration mechanism reminiscent to that observed in humans. Upon primaquine treatment, elimination of gametocytes from peripheral blood and from sequestration sites was observed, providing a proof of concept that these mice can be used for testing drugs. Therefore, this model allows the investigation of P. falciparum sexual commitment, gametocyte interactions with the bone marrow and spleen and provides the missing link between current in vitro assays and Phase I trials in humans for testing new malaria gametocytidal drugs.
Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice
Authors: Li Mingchang , Wang Wei , Mai Haojian , Zhang Xinmu , Wang Jian , Gao Yufeng , Wang Yuefei , Deng Gang , Gao Ling , Zhou Shuanhu , Chen Qianxue , Wang Xin 
Published: October 2016

AbstractSubarachnoid hemorrhage (SAH) results in significant nerve dysfunction, such as hemiplegia, mood disorders, cognitive and memory impairment. Currently, no clear measures can reduce brain nerve damage. The study of brain nerve protection after SAH is of great significance. We aim to evaluate the protective effects and the possible mechanism of methazolamide in C57BL/6J SAH animal model in vivo and in blood-induced primary cortical neuron (PCNs) cellular model of SAH in vitro. We demonstrate that methazolamide accelerates the recovery of neurological damage, effectively relieves cerebral edema, and improves cognitive function in SAH mice as well as offers neuroprotection in blood- or hemoglobin-treated PCNs and partially restores normal neuronal morphology. In addition, western blot analyses show obviously decreased expression of active caspase-3 in methazolamide-treated SAH mice comparing with vehicle-treated SAH animals. Furthermore, methazolamide effectively inhibits ROS production in PCNs induced by blood exposure or hemoglobin insult. However, methazolamide has no protective effects in morality, fluctuation of cerebral blood flow, SAH grade, and cerebral vasospasm of SAH mice. Given methazolamide, a potent carbonic anhydrase inhibitor, can penetrate the blood–brain barrier and has been used in clinic in the treatment of ocular conditions, it provides potential as a novel therapy for SAH.
Airy beam self-focusing in a photorefractive medium
Authors: Wiersma Noémi , Marsal Nicolas , Sciamanna Marc , Wolfersberger Delphine 
Published: October 2016

AbstractThe unique bending and shape-preserving properties of optical Airy beams offer a large range of applications in for example beam routing, optical waveguiding, particle manipulation and plasmonics. In these applications and others, the Airy beam may experience nonlinear light-matter interactions which in turn modify the Airy beam properties and propagation. A well-known example is light self-focusing that leads to the formation of spatial soliton. Here, we unveil experimentally the self-focusing properties of a 1D-Airy beam in a photorefractive crystal under focusing conditions. The transient evolution involves both self-bending and acceleration of the initially launched Airy beam due to the onset of an off-shooting soliton and the resulting nonlocal refractive index perturbation. Both the transient and stationary self-focusing properties can be tuned by varying the bias electric field, the injected Airy beam power and the background illumination.
Riboflavin photoactivation by upconversion nanoparticles for cancer treatment
Authors: Khaydukov E. V. , Mironova K. E. , Semchishen V. A. , Generalova A. N. , Nechaev A. V. , Khochenkov D. A. , Stepanova E. V. , Lebedev O. I. , Zvyagin A. V. , Deyev S. M. , Panchenko V. Ya. 
Published: October 2016

AbstractRiboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and irradiated with ultraviolet light, and proved that such Rf concentrations (60 μM) are attainable in vivo in tumour site by systemic intravascular injection. In order to extend the Rf photosensitization depth in cancer tissue to 6 mm in depth, we purpose-designed core/shell upconversion nanoparticles (UCNPs, NaYF4:Yb3+:Tm3+/NaYF4) capable to convert 2% of the deeply-penetrating excitation at 975 nm to ultraviolet-blue power. This power was expended to photosensitise Rf and kill SK-BR-3 cells preincubated with UCNPs and Rf, where the UCNP-Rf energy transfer was photon-mediated with ~14% Förster process contribution. SK-BR-3 xenograft regression in mice was observed for 50 days, following the Rf-UCNPs peritumoural injection and near-infrared light photodynamic treatment of the lesions.
Motivational context for response inhibition influences proactive involvement of attention
Authors: Langford Zachary D. , Schevernels Hanne , Boehler C. Nico 
Published: October 2016

AbstractMotoric inhibition is ingrained in human cognition and implicated in pervasive neurological diseases and disorders. The present electroencephalographic (EEG) study investigated proactive motivational adjustments in attention during response inhibition. We compared go-trial data from a stop-signal task, in which infrequently presented stop-signals required response cancellation without extrinsic incentives (“standard-stop”), to data where a monetary reward was posted on some stop-signals (“rewarded-stop”). A novel EEG analysis was used to directly model the covariation between response time and the attention-related N1 component. A positive relationship between response time and N1 amplitudes was found in the standard-stop context, but not in the rewarded-stop context. Simultaneously, average go-trial N1 amplitudes were larger in the rewarded-stop context. This suggests that down-regulation of go-signal-directed attention is dynamically adjusted in the standard-stop trials, but is overridden by a more generalized increase in attention in reward-motivated trials. Further, a diffusion process model indicated that behavior between contexts was the result of partially opposing evidence accumulation processes. Together these analyses suggest that response inhibition relies on dynamic and flexible proactive adjustments of low-level processes and that contextual changes can alter their interplay. This could prove to have ramifications for clinical disorders involving deficient response inhibition and impulsivity.