bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of BMI and age in predicting pathologic vertebral fractures in newly diagnosed multiple myeloma patients: A retrospective cohort study
Authors: Chen Yi‐Lun , Liu Yao‐Chung , Wu Chia‐Hung , Yeh Chiu‐Mei , Chiu Hsun‐I , Lee Gin‐Yi , Lee Yu‐Ting , Hsu Pei , Lin Ting‐Wei , Gau Jyh‐Pyng , Hsiao Liang‐Tsai , Chiou Tzeon‐Jye , Liu Jin‐Hwang , Liu Chia‐Jen 
Published: November 2017

AbstractVertebral fractures affect approximately 30% of myeloma patients and lead to a poor impact on survival and life quality. In general, age and body mass index (BMI) are reported to have an important role in vertebral fractures. However, the triangle relationship among age, BMI, and vertebral fractures is still unclear in newly diagnosed multiple myeloma (NDMM) patients.This study recruited consecutive 394 patients with NDMM at Taipei Veterans General Hospital between January 1, 2005 and December 31, 2015. Risk factors for vertebral fractures in NDMM patients were collected and analyzed. The survival curves were demonstrated using Kaplan‐Meier estimate. In total, 301 (76.4%) NDMM patients were enrolled in the cohort. In the median follow‐up period of 18.0 months, the median survival duration in those with vertebral fractures ≥ 2 was shorter than those with vertebral fracture < 2 (59.3 vs 28.6 months; P = 0.017). In multivariate Poisson regression, BMI < 18.5 kg/m2 declared increased vertebral fractures compared with BMI ≥ 24.0 kg/m2 (adjusted RR, 2.79; 95% CI, 1.44–5.43). In multivariable logistic regression, BMI < 18.5 kg/m2 was an independent risk factor for vertebral fractures ≥ 2 compared with BMI ≥ 24.0 kg/m2 (adjusted OR, 6.05; 95% CI, 2.43–15.08). Among age stratifications, patients with both old age and low BMI were at a greater risk suffering from increased vertebral fractures, especially in patients > 75 years and BMI < 18.5 kg/m2 (adjusted RR, 12.22; 95% CI, 3.02–49.40). This is the first study that demonstrated that age had a significant impact on vertebral fractures in NDMM patients with low BMI. Elder patients with low BMI should consider to routinely receive spinal radiographic examinations and regular follow‐up.
Analyzing epigenetic control of galectin expression indicates silencing of galectin‐12 by promoter methylation in colorectal cancer
Authors: Katzenmaier Eva‐Maria , Kloor Matthias , Gabius Hans‐Joachim , Gebert Johannes , Kopitz Juergen 
Published: November 2017

AbstractGalectins, a class of lectins with specificity for ß‐galactoside containing glycoconjugates, modulate several cellular processes that are involved in the control of normal cell growth, differentiation, cell‐cell, and cell matrix interactions. Pathological alterations of the galectin expression pattern have been implicated in the development and progression of cancer. We therefore analyzed epigenetic mechanisms for control of galectin expression in 9 colorectal cancer (CRC) cell lines. Our data demonstrate that expression of galectins‐1, −2, −7, −8, and −9 can be regulated by histone acetylation in CRC cell lines. In addition, the same set of galectins was also found to be modulated by DNA methylation. Of particular note, galectin‐12 is silenced in all tested CRC cell lines but known to be re‐expressed upon butyrate‐induced differentiation and present in normal colonic mucosa. Loss of galectin‐12 expression in undifferentiated CRC cells is associated with promoter hypermethylation and for the first time we provide detailed methylation analysis of the promoter region. In CRC tumor tissue, galectin‐12 expression was downregulated in 66% of CRC tissue specimens as compared to adjacent normal tissue hinting to a possible tumor‐suppressing function in CRC. © 2017 IUBMB Life, 69(12):962–970, 2017
Fabrication of interconnected porous β‐tricalcium phosphate (β‐TCP) based on a setting reaction of β‐TCP granules with HNO3followed by heat treatment
Authors: Ishikawa Kunio , Putri Tansza Setiana , Tsuchiya Akira , Tanaka Keisuke , Tsuru Kanji 
Published: November 2017

Abstractβ‐Tricalcium phosphate [β‐TCP] is the typical bone substitute due to its excellent osteoconductivity and bioresorbability. One of the keys to improve its potential as bone substitute is to introduce porous structure and its regulation. In this study, interconnected porous β‐TCP blocks were fabricated through a setting reaction of β‐TCP granules and subsequent heat treatment. First, β‐TCP granules were mixed with HNO3. Upon mixing, β‐TCP granules were bridged with dicalcium phosphate dihydrate [DCPD: CaHPO4·2H2O] containing Ca(NO3)2. Then, the DCPD‐bridged β‐TCP was heated at 1100°C. During the heating process, DCPD containing Ca(NO3)2transformed into β‐TCP and bonded with β‐TCP granules. As a result, an interconnected porous β‐TCP block formed. The diametral tensile strength and porosity of the interconnected porous β‐TCP block fabricated from 200–300‐μm β‐TCP granules and 5 N HNO3and then heated at 1,100°C were 1.4 ± 0.2 MPa and 57% ± 2%, respectively. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 797–804, 2018.
Pharmacokinetics, Immunogenicity, and Efficacy of Etanercept in Pediatric Patients With Moderate to Severe Plaque Psoriasis
Authors: Langley Richard G. , Kasichayanula Sree , Trivedi Mona , Aras Girish A. , Kaliyaperumal Arunan , Yuraszeck Theresa , Gibbs John , Gibbs Megan , Kricorian Greg , Paller Amy S. 
Published: November 2017

AbstractEtanercept has been recently approved in the United States for the treatment of moderate to severe plaque psoriasis in patients aged 4–17 years. The objective of this study was to characterize etanercept pharmacokinetics, immunogenicity, and efficacy in pediatric patients. Data from a phase 3 study and open‐label extension study were analyzed. Etanercept serum concentrations in pediatric patients receiving etanercept 0.8 mg/kg (maximum, 50 mg) weekly were compared with adult psoriasis patients and pediatric patients with juvenile idiopathic arthritis (JIA) who received etanercept 0.4 mg/kg twice weekly. The developments of antietanercept antibodies and efficacy based on the Psoriasis Area and Severity Index were evaluated. Steady‐state trough etanercept concentrations were similar across visits from weeks 12–48, between patients aged 4–11 and 12–17 years, between pediatric and adult psoriasis patients, and between pediatric patients with psoriasis or JIA. Etanercept serum concentrations and safety profiles were similar in patients with (15.9%) and without antietanercept antibodies. Dosing used in the study provided similar exposures and efficacy across ranges of weight and body mass index. Pharmacokinetic, immunogenicity, and efficacy data support 0.8 mg/kg (maximum, 50 mg) weekly dosing of etanercept in patients aged 4–17 years.
Interannual variation of precipitation over the Hengduan Mountains during rainy season
Authors: Dong Danhong , Huang Gang , Tao Weichen , Wu Renguang , Hu Kaiming , Li Chaofan 
Published: November 2017

ABSTRACTThe present study investigates the interannual variability of precipitation over the Hengduan Mountains (HMs) during rainy season based on daily precipitation dataset of 151 meteorological stations. More HMs precipitation is associated with an anomalous lower level cyclonic circulation over the northern South China Sea (SCS) and the upper level Silk Road pattern (SRP)‐like geopotential height anomalies. Along the north flank of the anomalous cyclonic circulation, easterly wind anomalies weaken climatology winds and prevent further movement of southwest moisture transport, leading to the enhancement of moisture convergence over HMs. Diagnosis shows that anomalous vertical motions are owing to the advection of anomalous temperature by basic zonal winds. The anomalous lower level cyclonic circulation over the northern SCS is related to La Niña‐like sea surface cooling in the equatorial central and eastern Pacific. This cooling adjusts the Walker Circulation, causing positive precipitation anomalies near the SCS, which trigger the anomalous cyclonic circulation as a warm Rossby wave response. The distribution of upper level geopotential height anomalies over the mid‐latitude Asian land resembles the SRP. Due to its barotropic structure, the SRP leads to warm and cold anomalies over the central Asia and the central China, respectively. The advection of anomalous temperature gradient by mean westerlies leads to anomalous ascending motions and more precipitation over HMs.
Quantifying meniscal kinematics in dogs
Authors: Park Brian H , Banks Scott A , Pozzi Antonio 
Published: November 2017

ABSTRACTThe dog has been used extensively as an experimental model to study meniscal treatments such as meniscectomy, meniscal repair, transplantation, and regeneration. However, there is very little information on meniscal kinematics in the dog. This study used MR imaging to quantify in vitro meniscal kinematics in loaded dog knees in four distinct poses: extension, flexion, internal, and external rotation. A new method was used to track the meniscal poses along the convex and posteriorly tilted tibial plateau. Meniscal displacements were large, displacing 13.5 and 13.7 mm posteriorly on average for the lateral and medial menisci during flexion (p = 0.90). The medial anterior horn and lateral posterior horns were the most mobile structures, showing average translations of 15.9 and 15.1 mm, respectively. Canine menisci are highly mobile and exhibit movements that correlate closely with the relative tibiofemoral positions. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1710–1716, 2018.
Synthesis and application of a novel solid‐phase extraction adsorbent for multiresidue analysis of insecticides in water
Authors: Xiong Jingjing , Li Huizhen , Ma Xue , You Jing 
Published: November 2017

AbstractA new solid‐phase adsorbent was synthesized for the simultaneous enrichment of multiple classes of trace insecticides (neonicotinoids, organophosphates, fiproles, and organochlorines) in water. The adsorbent was spherical with a diameter, surface area, average pore volume, and pore size of approximately 5 μm, 341 m2/g, 0.092 m3/g, and 2.22 nm, respectively. Extraction conditions were optimized, including water pH and the type and volume of the rinsing and eluting solvents. After extraction, target insecticides were analyzed by gas chromatography with mass spectrometry and high‐performance liquid chromatography with tandem mass spectrometry. The recovery of neonicotinoids ranged from 63.0 to 124%, except for clothianidin (40.1–52.9%). Recoveries of organophosphates, fiproles, and organochlorines were in the ranges of 37.0–102, 64.0–101, and 42.0–69.3%, respectively. Relative standard deviations were <20% except for profenofos (5.1–30%) and method detection limits were 1.8–12.7 ng/L, suggesting that the precision and accuracy of the developed method were viable. At environmentally relevant concentrations, the new adsorbent achieved comparable recoveries of target insecticides to hydrophilic–lipophilic balance adsorbent while providing an additional advantage by further reducing matrix effects. Field water samples from the Pearl River in Guangzhou, China were analyzed, and the frequent detection of neonicotinoids raises concerns about their aquatic risk.
Tourism price causalities: Case of an Adriatic country
Authors: Gricar Sergej , Bojnec Stefan 
Published: November 2017

AbstractThe aim of this article is to investigate the linearities and causalities between Slovenian tourism and macroeconomic aggregates. The monthly time‐series data for the drivers of the rise in the Slovenian hospitality industry prices are tested in the vector autoregressive framework and smooth transition autoregressive model during the 3 specific subperiods. The results are robust for the applied linear methods on prices and value‐added tax sensitive tourist demand and for the applied nonlinear methods on exchange rate and labor costs. Granger causality tests confirmed 5 correlations in the set of 3 hypotheses. Input costs are significant drivers for the rise of the Slovenian hospitality industry prices.
Motor and sensory morbidity associated with the anterolateral thigh perforator free flap
Authors: Noel Christopher W. , Vosler Peter S. , Hong Michael , Orsini Mario , Sultanov Fayzullo , Lu Zihang , Busato Gian‐Marco , Enepekides Danny , Higgins Kevin 
Published: November 2017

ObjectiveTo quantify changes in motor function, sensation, and lower extremity quality of life following anterior lateral thigh free flap (ALT) resection.MethodsThis mixed methods study contained both a prospective cohort arm (n = 20) and retrospective cross‐sectional arm (n = 20). In both arms, patients underwent formal motor and sensation testing of the ipsilateral and contralateral thigh by sphygmomanometry and monofilament testing. In the prospective arm, data was collected preoperatively and at the 6‐month and 1‐year follow‐up visits. In the retrospective arm, consecutive patients with a minimum of 6‐month postoperative follow‐up were enrolled.ResultsPostoperatively, 82% of participants endorsed some degree of numbness and tingling at the donor site. On monofilament testing, patients from the prospective arm showed decreased sensibility of the midthigh at both the 6‐ and 12‐month assessment (P < 0.01). Two‐point discrimination scores were moderately correlated with the cross‐sectional surface area of the flap. Donor thighs demonstrated a similar peak isometric quadriceps contraction (retrospective [retro]: 47 ± 24 mmHg, prospective [pro]: 90 ± 36 mmHg) to the unoperated thighs (retro: 43 mmHg ± 22, pro: 69 ± 35.3 mmHg, P = 0.49). When stratified by perforator anatomy, no significant differences were noted. Subjective donor site morbidity measured with the lower extremity function scale demonstrated no statistically significant difference between the preoperative and 12‐month postoperative assessment.ConclusionThe ALT flap offers minimal donor site morbidity. Reduced sensibility of the ALT flap is a common complaint among patients. Quadriceps strength is not significantly affected by an ALT free flap harvest.Level of Evidence4. Laryngoscope, 128:1057–1061, 2018
The Effect of Berry‐Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials
Authors: Heneghan Clara , Kiely Mairead , Lyons Jacqueline , Lucey Alice 
Published: November 2017

ScopeEpidemiological evidence, animal, and in vitro studies suggest that berry consumption may ameliorate markers of cardiovascular disease (CVD). The aim of this systematic review is to evaluate findings from berry‐based randomized controlled trials (RCTs) to establish the effects of berry consumption on markers of cardiovascular and metabolic health.Methods and resultsPubMed and Web of Science are searched for RCTs investigating berry consumption on CVD risk outcomes in adults. A total of 23 studies (which includes 1168 participants) out of 1384 records meet the inclusion criteria. Of these 23 studies, 17 RCTs are of high quality, where 12 RCTs (71%) report beneficial effects of berry consumption on CVD risk markers. Overall, 4/11 RCTs that observe a reduction in systolic and/or diastolic blood pressure (BP); 3/7 RCTs report favorable effects on endothelial function, 2/3 RCTs report improvements in arterial stiffness, 7/17 studies observe benefits in blood lipids, and 3/6 studies report improvements in glycemic profile.ConclusionOur evaluation of the literature indicates that more than two‐thirds of high‐quality trials have reported beneficial effects of berry consumption on markers of CVD risk. This systematic review contributes moderate to strong evidence for the inclusion of berries as part of a cardioprotective diet.
The prevalence of lower urinary tract symptoms (LUTS) in Brazil: Results from the epidemiology of LUTS (Brazil LUTS) study
Authors: Soler Roberto , Gomes Cristiano Mendes , Averbeck Marcio Augusto , Koyama Mitti 
Published: November 2017

AimsWe performed the first large population‐based study to evaluate lower urinary tract symptoms (LUTS) in Brazil. The study objective was to assess the prevalence and bother of LUTS in the population aged ≥40 years in five major cities of Brazil.MethodsThis study was conducted as a telephone survey with assessment of LUTS using a standardized protocol, which included the International Prostate Symptom Score (IPSS) and, for overactive bladder (OAB), the OAB‐V8 questionnaire. Participants were asked to rate how often they experienced individual LUTS and the degree of associated bother.ResultsOf the 5184 participants, 53% were women, and the age group with most participants (34%) was 50‐59 years. The prevalence of LUTS (symptoms occurring less than half the time or more) was 75%: 69% in men and 82% in women. There was a statistically significant association between the frequency and bother intensity of each symptom (P < 0.001). The prevalence of OAB was similar in men and women (25% and 24%, respectively). According to the IPSS questionnaire, moderate‐to‐severe symptoms were present in 21% of men and 24% of women. LUTS detrimentally affected quality of life in many individuals: 39% would be “mostly dissatisfied,” “unhappy,” or consider it “terrible” to spend the rest of their life with their urinary condition as it is currently.ConclusionsThis was the first nationwide, population‐based epidemiological study of LUTS to be performed in Brazil. LUTS are highly prevalent and often bothersome among men and women aged ≥40 years.
Imidazole improves cognition and balances Alzheimer's‐like intracellular calcium homeostasis in transgenic Drosophila model
Authors: Li Min , Zhang Wanrong , Wang Wei , He Qing , Yin Mengmei , Qin Xue , Zhang Tongyu , Wu Ting 
Published: November 2017

AimsThe characteristic of Alzheimer's disease (AD) is the accumulation and aggregation of amyloid‐β (Aβ). So far, we already know that the dysregulation of intracellular calcium homeostasis is considered to be associated with Aβ neurotoxicity. Meantime, we also found that the channels formed by Aβ are electronegative as calcium channels. Base on this hypothesis, the formation of Aβ channels will provide us with a new therapeutic direction for AD. Aβ channel hypothesis is proposed that the axis of Aβ channel's pore was encompasses by the His13–His14 diad. Imidazole especially the imidazole ring was supposed binding to the side chains of Aβ peptides.MethodsIn our study, we adopted Gal4/UAS system to establish transgenic drosophila model which lay a good foundation to explore the imidazole's function and mechanism of action.ResultsThe results suggested that Imidazole could not only improve the cognition of Aβ42‐expressing flies, but also decreases p‐JNK activation in whole brain of Aβ42‐expressing flies.ConclusionsFurthermore, freshly prepared oligomeric Aβ42 peptide ascended primary pupal neuronal calcium concentration and this phenomenon was alleviated by Imidazole and Zn2+.
Hybrid multiscale integration for directionally scale separable problems
Authors: Zhang Shuhai , Oskay Caglar 
Published: November 2017

SummaryThis manuscript presents the formulation and implementation of a hybrid multiscale integration scheme for multiscale problems that exhibit different scale separation characteristics in different directions. The proposed approach uses the key ideas of the variational multiscale enrichment at directions that exhibit poor scale separation and computational homogenization at directions with good scale separability. The proposed approach is particularly attractive for surface degradation problems in structures operating in the presence of aggressive environmental agents. Formulated in the context of variational multiscale principles, we develop a novel integration scheme that takes advantage of homogenization‐like integration along directions that exhibit scale separation. The proposed integration scheme is applied to the reduced‐order variational multiscale enrichment method to arrive at a computationally efficient multiscale solution strategy for surface degradation problems. Numerical verifications are performed to verify the implementation of the hybrid multiscale integrator. The results of the verifications reveal high accuracy and computational efficiency, compared with the direct reduced‐order variational multiscale enrichment simulations. A coupled transport‐thermomechanical analysis is presented to demonstrate the capability of the proposed computational framework.
NTHL1 and MUTYH polyposis syndromes: two sides of the same coin?
Authors: Weren Robbert DA , Ligtenberg Marjolijn JL , Geurts van Kessel Ad , De Voer Richarda M , Hoogerbrugge Nicoline , Kuiper Roland P 
Published: November 2017

AbstractIt is now well established that germline genomic aberrations can underlie high‐penetrant familial polyposis and colorectal cancer syndromes, but a genetic cause has not yet been found for the major proportion of patients with polyposis. Since next‐generation sequencing has become widely accessible, several novel, but rare, high‐penetrant risk factors for adenomatous polyposis have been identified, all operating in pathways responsible for genomic maintenance and DNA repair. One of these is the base excision repair pathway. In addition to the well‐established role of the DNA glycosylase gene MUTYH, biallelic mutations in which predispose to MUTYH‐associated polyposis, a second DNA glycosylase gene, NTHL1, has recently been associated with adenomatous polyposis and a high colorectal cancer risk. Both recessive polyposis syndromes are associated with increased risks for several other cancer types as well, but the spectrum of benign and malignant tumours in individuals with biallelic NTHL1 mutations was shown to be broader; hence the name NTHL1‐associated tumour syndrome. Colorectal tumours encountered in patients with these syndromes show unique, clearly distinct mutational signatures that may facilitate the identification of these syndromes. On the basis of the prevalence of pathogenic MUTYH and NTHL1 variants in the normal population, we estimate that the frequency of the novel NTHL1‐associated tumour syndrome is five times lower than that of MUTYH‐associated polyposis. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Associations between school climate, suicidal thoughts, and behaviors and ethnicity among middle school students
Authors: La Salle Tamika P. , Wang Cixin , Parris Leandra , Brown Jacqueline A. 
Published: November 2017

AbstractThe purpose of the current study is to investigate the relationships between suicidal thoughts and behaviors (STBs), school climate, and student demographics among middle school students. The study was conducted with a sample of 152,191 middle school students across 607 schools within 182 school districts in a southeastern state. Results support prior research that positive perceptions of school climate are associated with fewer reports of STB. Participants identified family reasons, bullying, peer problems, and “other” as the most common reasons for STB. Further, older students and males were more likely to engage in STB than their counterparts. When examining cross‐sectional interactions, race/ethnicity moderated the relationship between school climate and STB. Findings from the study support the role of school psychologists in advocating for prevention and intervention STB supports for middle school students with particular attention to students who may be at increased risk based on group identification. Implications for future research and practice are discussed.