bluuebunny/crossref_metadata_2025_split huggingface dataset:
A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies
Authors: Marr Alexandra K. , Boughorbel Sabri , Presnell Scott , Quinn Charlie , Chaussabel Damien , Kino Tomoshige 
Published: May 2016

Compendia of large-scale datasets made available in public repositories provide a precious opportunity to discover new biomedical phenomena and to fill gaps in our current knowledge. In order to foster novel insights it is necessary to ensure that these data are made readily accessible to research investigators in an interpretable format. Here we make a curated, public, collection of transcriptome datasets relevant to human placenta biology available for further analysis and interpretation via an interactive data browsing interface. We identified and retrieved a total of 24 datasets encompassing 759 transcriptome profiles associated with the development of the human placenta and associated pathologies from the NCBI Gene Expression Omnibus (GEO) and present them in a custom web-based application designed for interactive query and visualization of integrated large-scale datasets (http://placentalendocrinology.gxbsidra.org/dm3/landing.gsp). We also performed quality control checks using relevant biological markers. Multiple sample groupings and rank lists were subsequently created to facilitate data query and interpretation. Via this interface, users can create web-links to customized graphical views which may be inserted into manuscripts for further dissemination, or e-mailed to collaborators for discussion. The tool also enables users to browse a single gene across different projects, providing a mechanism for developing new perspectives on the role of a molecule of interest across multiple biological states. The dataset collection we created here is available at: http://placentalendocrinology.gxbsidra.org/dm3.
An anthropomorphic transhumeral prosthesis socket developed based on an oscillometric pump and controlled by force-sensitive resistor pressure signals
Authors: Razak N.A. Abd , Gholizadeh H. , Hasnan N. , Osman N.A. Abu , Fadzil S.S. Mohd , Hashim N.A. 
Published: May 2016

AbstractWhile considering the importance of the interface between amputees and prosthesis sockets, we study an anthropomorphic prosthesis socket whose size can be dynamically changed according to the requirements of the residual limb. First, we introduce the structure and function of the anthropomorphic prosthesis socket. Second, we study the dynamic model of the prosthesis system and analyze the dynamic characteristics of the prosthesis socket system, the inputs of an oscillometric pump, and the control mechanism of force-sensitive resistor (FSR) pressure signals. Experiments on 10 healthy subjects using the designed system yield an average detection result between 102 and 112 kPa for the FSR pressure sensor and 39 and 41 kPa for the oscillometric pump. Results show the function of the FSR pressure signal in maintaining the contact pressure between the sockets and the residual limb. The potential development of an auto-adjusted socket that uses an oscillometric pump system will provide prosthetic sockets with controllable contact pressure at the residual limb. Moreover, this development is an attractive research area for researchers involved in rehabilitation engineering, prosthetics, and orthotics.
Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst
Authors: Alinezhad Heshmatollah , Tajbakhsh Mahmood , Zare Mahboobeh , Mousavi Mahbooeh 
Published: May 2016

AbstractA one-pot three-component Biginelli-like reaction of enaminones, aldehydes with urea/thiourea in the presence of 2-pyrrolidonium bisulphate as an acidic ionic liquid catalyst for the preparation of 6-unsubstituted dihydropyrimidinones is described. The excellent yield, short reaction time, simple procedure and avoidance of the use of organic solvents are some advantages of this method.
Mobile phone exposure influences some erythrocytes parameters in vitro. A novel source of preanalytical variability?
Authors: Danese Elisa , Lippi Giuseppe , Brocco Giorgio , Montagnana Martina , Salvagno Gian Luca 
Published: May 2016

Abstract

Background: The effect of radiofrequency exposure on human health and health care equipment is a matter of ongoing debate. This study was planned to investigate the influence of radiofrequency (RF) waves emitted by a commercial mobile phone on red blood cells (RBC) in vitro.

Methods: The study population consisted of 16 ostensibly healthy volunteers. Two whole blood specimens were collected from each volunteer. One sample was placed in a plastic rack, 1 cm distant from the chassis of a commercial mobile phone which was activated by a remote phone call lasting 30 min. The other blood sample was placed in another plastic rack, but was kept distant from any type of RF source. The main RBC parameters including RBC count, hematocrit (Ht), hemoglobin, mean corpuscular platelet volume (MPV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and RBC distribution width (RDW-CV) were assessed with an Advia 2120.

Results: The exposure of whole blood to the mobile phone call significantly increased Ht, hemoglobin, MCV and MCH, whereas the RBC count, MCHC and RDW-CV remained unchanged. A significant correlation was observed between variation of Ht and those of hemoglobin (p=0.008), MCV (p=0.009) or MCH (p=0.037), as well as between hemoglobin and MCV (p=0.048). Increased values were found in 13/16 (81%) samples for both Ht and hemoglobin, 14/16 (88%) samples for MCH and 16/16 (100%) samples for MCV.

Conclusions: These results suggest that close mobile phone exposure may be an unappreciated and possibly underestimated cause of preanalytical bias in RBC testing.
Comparative study of the topochemistry on delignification of Japanese beech (Fagus crenata) in subcritical phenol and subcritical water
Authors: Takada Masatsugu , Tanaka Yoshiki , Minami Eiji , Saka Shiro 
Published: May 2016

Abstract
The delignification of Japanese beech (Fagus crenata) has been evaluated under conditions of subcritical phenol (230°C/1.2 MPa) and subcritical water (230°C/2.9 MPa). In the former, more than 90% of the original lignin was decomposed and removed, while in subcritical water, around half of the original lignin was left as insoluble residue. Ultraviolet (UV) microscopic images of the insoluble residues showed that the lignin in the secondary walls is decomposed and removed under both conditions. These images also revealed that the lignin in the compound middle lamella (CML) is resistant to subcritical water, but not to subcritical phenol. Results of alkaline nitrobenzene oxidation of the residual lignin confirmed these observations. Lignin in Japanese beech wood was phenolated by subcritical phenol, which was efficiently removed due to its high solubility in the reactant. It is obvious that CML is rich in condensed-type linkages facilitating rapid solvolysis by phenol. The topochemistry of the plant has a pronounced impact on its delignification behavior.
Konkurrenz um Kalkstein. Rohstoffsicherung der Montanindustrie und die Dynamik räumlicher Relationen um 1900
Authors: Haumann Sebastian 
Published: May 2016

Abstract
Limestone, a resource that was needed to smelt iron ore and to produce steel, became an object of competition between industrialists of the Ruhr around 1900. The making and transformation of spatial relations was crucial to the process of gaining exclusive access to the resource. First, images of the underground terrain, namely the identification and delineation of limestone deposits, were variable and subject to negotiation – albeit bound to physical space through procedures of surveying and chemical analysis. Second, the changing structure of real-estate property constituted new spatial relations. As limestone companies bought up property from local farmers, the social implications of land ownership slowly eroded. Instead, the spatial structure of property was reorganized around safeguarding an exclusive and unrestricted access to limestone deposits. Third, the companies' interventions transformed spatial relations by realigning infrastructures and restricting potentially conflicting uses of land. In the end, they also transformed much of the physical space by expanding quarries in unprecedented dimensions. All these processes were driven and shaped in a highly competitive setting in which not only competing companies but also the local populace gained decisive influence. The aim of this case study is to show that space was not a fixed “container” in which companies and locals pursued their economic interests. Rather, spatial relations were brought about, and hence made, amid the competition for the resource as these relations became the precondition for resource extraction.
Kuhanspannung in Mitteleuropa: Ein vergessenes Element der Agrarrevolution?
Authors: Troßbach Werner 
Published: May 2016

Abstract
Cow traction was a major source of energy in the agriculture of various European countries deep into the 1950s. As the losses in milk yields were by far outstripped by energy gains, a great number of continental smallholders preferred cows to horses and oxen regardless of a negative impact on labour productivity. However, the triple use of cows (milk, meat and traction) became widespread only after 1800 in accordance with an increasing availability of fodder resources. In this sense the expansion of cow traction can be considered as that part of the agricultural revolution which contributed to the protracted survival of smallholder economies in countries like Austria, Czechoslovakia, France, Germany and Switzerland.
Design and Development of a Framework for an Automatic Answer Evaluation System Based on Similarity Measures
Authors: Ramamurthy Madhumitha , Krishnamurthi Ilango 
Published: May 2016

AbstractThe assessment of answers is an important process that requires great effort from evaluators. This assessment process requires high concentration without any fluctuations in mood. This substantiates the need to automate answer script evaluation. Regarding text answer evaluation, sentence similarity measures have been widely used to compare student written answers with reference texts. In this paper, we propose an automated answer evaluation system that uses our proposed cosine-based sentence similarity measures to evaluate the answers. Cosine measures have proved to be effective in comparing between free text student answers and reference texts. Here we propose a set of novel cosine-based sentence similarity measures with varied approaches of creating document vector space. In addition to this, we propose a novel synset-based word similarity measure for computation of document vectors coupled with varied approaches for dimensionality-reduction for reducing vector space dimensions. Thus, we propose 21 cosine-based sentence similarity measures and measured their performance using MSR paraphrase corpus and Li’s benchmark datasets. We also use these measures for automatic answer evaluation system and compare their performances using the Kaggle short answer and essay dataset. The performance of the system-generated scores is compared with the human scores using Pearson correlation. The results show that system and human scores have correlation between each other.
A Fuzzy Logic Modeling of Measures Addressing Shipping CO2 Emissions
Authors: Lema Evaggelia , Karaganis Anastasios , Papageorgiou Elpiniki 
Published: May 2016

AbstractThis study presents a decision support tool that uses a fuzzy logic model of expert knowledge to assist in the decision-making process in the context of mitigating shipping CO2 emissions. The issue of selecting a market-based shipping CO2 emission mechanism, as they were presented by the International Maritime Organization (IMO), has generated much discussion over the last decade due to the complexity of the industry. We built a fuzzy logic system using the input and output variables as well as their range values that have been set from the IMO Expert Group study. We developed 27 fuzzy rules based on the literature and our domain knowledge, and we ran the fuzzy inference system for four of the proposed market-based measures. Finally, we evaluated our results and compared them with the IMO Expert Group study. Although not all measures responded the same, especially regarding the emission reductions, the percentage agreement is satisfactory in most of the cases (60–95%). The strength of the tool is that it synthesizes a large amount of information in a logical and transparent framework, and has the potential to have wider application in the context of market-based measures.
Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism) on Weight Loss and Cardiovascular Risk Factors after Liraglutide Treatment in Obese Patients with Diabetes Mellitus Type 2
Authors: de Luis Daniel Antonio , Ovalle Hilda F. , Soto Gonzalo Diaz , Izaola Olatz , de la Fuente Beatriz , Romero Enrique 
Published: May 2016

Background A polymorphism (1359 G/A) of the cannabinoid receptor 1 ( CNR1) gene was reported as a common polymorphism (rs1049353) with potential implications in weight loss. We decide to investigate the role of this polymorphism on metabolic changes and weight loss secondary to treatment with liraglutide. Methods A population of 86 patients with diabetes mellitus type 2 and obesity, unable to achieve glycemic control (hemoglobine glycate A1c >7%) with metformin alone or associated to sulfonylurea, who require initiation of liraglutide treatment in progressive dose to 1.8 mg/d subcutaneously, was analyzed. Results Fifty-one patients (59.3%) had the genotype G1359G, and 35 patients (40.7%) had G1359A (28 patients, 32.6%) or A1359A (7 patients, 8.1%) (A allele carriers). In patients with both genotypes, basal glucose, HbA1c, body mass index, weight, fat mass, waist circumference, and systolic blood pressures decreased. In patients with G1359G genotype, total cholesterol and low-density lipoprotein cholesterol decreased, and in patients with A allele, homeostasis model assessment for insulin resistance decreased, too. Conclusions There is an association of the A allele with an improvement of insulin resistance secondary to weight loss after liraglutide treatment in obese patients with diabetes mellitus type 2. Noncarriers of A allele showed an improvement in cholesterol levels after weight loss.
Cardiac and Renal Hormones
Authors: Vesely David L. 
Published: May 2016

Background Four cardiovascular hormones, ie, vessel dilator, long-acting natriuretic peptide, kaliuretic peptide, and atrial natriuretic peptide each at 1 mmol/L, decrease up to 97% of human breast, ovarian, pancreatic, colon, kidney, and prostate adenocarcinoma cells, as well as small cell and squamous cell lung cancer cells within 24 hours. Methods Vessel dilator, long-acting natriuretic peptide, and kaliuretic peptide were investigated in vivo. Results These cardiac hormones completely stop the growth of human pancreatic adenocarcinomas in athymic mice and decrease their tumor volume by 49%, 28%, and 11%, respectively, in 1 week. When these cardiac hormones are given subcutaneously for 1 month via osmotic pumps with the pumps changed weekly, up to 80% of the human pancreatic adenocarcinomas growing in athymic mice can be completely eliminated. Similarly, two thirds of human breast cancers in athymic mice can be eliminated without surgery with these cardiac hormones. Natriuretic peptide receptors A-, B-, and C- are present on the cancer cells to mediate atrial natriuretic peptide's effects. Conclusions The cardiac hormones' anticancer mechanism of action(s) include a strong inhibition of mitogen (epidermal growth factor and insulin) activated extracellular signal-regulated kinases (ERK) 1/2 and as well as inhibition of basal extracellular-signal regulated kinase 1/2 and upstream MEK 1/2 phosphorylation. They cause 80% to 90% inhibition of DNA synthesis in the nucleus where these cardiac hormones have been demonstrated to localize by immunocytochemical techniques.
The Value of Osteopontin in the Assessment of Bone Mineral Density Status in Postmenopausal Women
Authors: Fodor Daniela , Bondor Cosmina , Albu Adriana , Simon Siao-pin , Craciun Alexandra , Muntean Laura 
Published: May 2016

Background Osteopontin (OPN) has been implicated in bone remodeling by activating the resorption process. We aimed to study the relationship between OPN, bone mineral density (BMD), bone turnover markers, vitamin D, and osteoporotic vertebral fractures in postmenopausal women. Materials and Methods Serum levels of OPN, osteocalcin, collagen type 1 cross-linked C-telopeptide (CTX), bone alkaline phosphatase, and vitamin D were assessed in 214 postmenopausal women. Bone mineral density was assessed by dual-energy x-ray absorptiometry in lumbar spine and femoral neck, and osteoporotic vertebral fractures by radiographs. Results Osteopontin levels were significantly higher in osteoporosis group versus osteopenic and normal group (all P < 0.05). The cutoff values of OPN for osteoporosis diagnosis were of 9.47 μg/L at the lumbar spine (area under the curve, 0.67; 95% confidence interval, 0.58–0.75; P < 0.001) and 10.15 μg/L at the femoral neck (area under the curve, 0.69; 95% confidence interval, 0.624–0.77; P = 0.0001), respectively. Postmenopausal women with osteoporosis-related vertebral fractures had significantly higher levels of OPN than those without vertebral fractures (15.69 ± 13.26 vs 12.63 ± 12.46 μg/L; P = 0.02). Significant negative correlations were found between OPN and BMD, which persisted after the adjustment for age at the lumbar spine. Osteopontin levels were directly correlated with bone turnover markers (osteocalcin, bone alkaline phosphatase, and CTX). No significant correlation was found between OPN and vitamin D. Multiple regression analysis showed that age, waist circumference, and CTX were independent predictors of serum OPN levels. Conclusions High levels of OPN in postmenopausal women are associated with low BMD, increased levels of bone turnover markers, and osteoporotic vertebral fractures. These findings suggest that OPN might play some role in the pathophysiology of postmenopausal osteoporosis and warrant further clinical investigations.
The rs9939609 Gene Variant in FTO Modified the Metabolic Response of Weight Loss After a 3-Month Intervention With a Hypocaloric Diet
Authors: de Luis Daniel Antonio , Aller Rocío , Conde Rosa , Izaola Olatz , Sagrado Manuel Gonzalez , Castrodeza Sanz Javier 
Published: May 2016

Background Common polymorphisms in the fat mass and obesity associated gene ( FTO) have been linked to obesity in some populations. Nevertheless, the role of FTO variants on body weight response after dietary intervention remains equivocal. Objective We decided to analyze the effects of the rs9939609 FTO gene polymorphism on body weight changes and metabolic parameters after 3 months of a hypocaloric diet. Design Before and after 3 months on a low-fat hypocaloric diet, a white population of 106 subjects with obesity was analyzed. Results Of the study subjects, 35 (33%) had the genotype TT and 71 (67%) had the next genotypes; TA (46 study subjects, 43.4%) or AA (25 study subjects, 23.6%). After dietary treatment and in TT group, weight, waist circumference, total cholesterol, LDL-cholesterol, insulin, and homeostasis model assessment decreases were less than subjects carrying the A allele [−3.1 (3.6) vs −2.4 (4.1) kg: P < 0.05], waist circumference [−5.4 (6.4) vs −2.6 (4.8) cm; P < 0.05], total cholesterol [−12.3 (35.3) vs −6.4 (4.7) mg/dL; P < 0.05], LDL-cholesterol [−22.3 (30.5) vs −10.7 (30.5) mg/dL; P < 0.05], insulin [−1.89 (5.5) vs +0.94 (8.2) mUI/L; P < 0.05], and homeostasis model assessment [−0.46 (1.11) vs −0.01 (2.4); P < 0.05]. Conclusions Our study confirmed a higher weight loss in A carriers of FTO rs9939609 polymorphism than in TT genotype study subjects.
Serum Pentraxin 3 Levels are Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris
Authors: Karakas Mehmet Fatih , Buyukkaya Eyup , Kurt Mustafa , Motor Sedat , Akcay Adnan Burak , Buyukkaya Şule , Karakas Esra , Bilen Perihan , Sen Nihat 
Published: May 2016

Background Atherosclerosis is a complex inflammatory process in which inflammatory markers are involved. Although pentraxin 3 (PTX-3), a newly identified inflammatory marker, was associated with adverse outcomes in stable angina pectoris, no association between PTX-3 and the complexity of coronary artery disease (CAD) has been reported. Thus, the aim of the present study was to assess the association between the level of PTX-3 and the complexity and severity of CAD assessed with SYNTAX and Gensini scores in patients with stable angina pectoris. Methods The study population consisted of 2 groups: 161 patients with anginal symptoms and evidence of ischemia who underwent coronary angiography and 50 age- and sex- matched control subjects without evidence of ischemia were included. Patients were grouped into 3 groups according to the complexity and severity of coronary lesions assessed by the SYNTAX score (30 patients with a SYNTAX score of 0 were excluded). Serum PTX-3 and high-sensitivity C-reactive protein (hs-CRP) levels were measured. Results The PTX-3 levels demonstrated an increase from low to high SYNTAX groups ( r = 0.72, P < 0.001). Whereas the low SYNTAX group had statistically significantly higher PTX-3 levels when compared with the control group (0.50 ± 0.01 vs 0.24 ± 0.01 ng/mL, P < 0.001), the hs-CRP levels were not different (0.81 ± 0.42 vs 0.86 ± 0.53 mg/dL, P = 0.96). However, the intermediate SYNTAX group had higher hs-CRP levels compared with the low SYNTAX group (1.3 ± 0.66 vs 0.86 ± 0.53 mg/dL, P = 0.002). Serum PTX-3 levels and hs-CRP levels were correlated with the SYNTAX scores and Gensini scores (for SYNTAX: r = 0.87 [ P < 0.001] and r = 0.36 [ P = 0.01]; for Gensini: r = 0.75 [ P < 0.001] and r = 0.27 [ P = 0.002], respectively), and according to the results of univariate and multivariate analyses, for “intermediate and high” SYNTAX scores, age, diabetes mellitus, low-density lipoprotein cholesterol, hs-CRP, and PTX-3 were found to be independent predictors, whereas for the presence of “high” SYNTAX score only PTX-3 was found to be an independent predictor. The receiver operating characteristic curve analysis further revealed that the PTX-3 level was a strong indicator of high SYNTAX score with an area under the curve of 0.91 (95% confidence interval, 0.86-0.96). Conclusions Pentraxin 3, a novel inflammatory marker, was more tightly associated with the complexity and severity of CAD than hs-CRP and was found to be an independent predictor for high SYNTAX score.
Hydrogen storage kinetics of nanocrystalline and amorphous NdMg12-type alloy–Ni composites synthesized by mechanical milling
Authors: Zhang Yanghuan , Cui Songsong , Song Xiping , Zhang Peilong , Zhu Yongguo , Cai Ying 
Published: May 2016

Abstract
Nanocrystalline and amorphous NdMg11Ni + x wt.% Ni (x = 100, 200) composites were synthesized by mechanical milling, and their gaseous and electrochemical hydrogen storage kinetic performances were systematically investigated. Hydrogen absorption and desorption properties were investigated by means of a Sievert apparatus and a differential scanning calorimeter connected with an H2 detector. Electrochemical hydrogen storage kinetics of the as-milled alloys were tested by an automatic galvanostatic system. Results show that increasing Ni content significantly improves gaseous and electrochemical hydrogen storage kinetics. The improved gaseous hydrogen storage kinetics of the alloys are ascribed to the decrease in hydrogen desorption activation energy caused by increasing Ni content and milling time.