bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonmineralized and Mineralized Collagen Scaffolds Induce Differential Osteogenic Signaling Pathways in Human Mesenchymal Stem Cells
Authors: Zhou Qi , Ren Xiaoyan , Bischoff David , Weisgerber Daniel W. , Yamaguchi Dean T. , Miller Timothy A. , Harley Brendan A. C. , Lee Justine C. 
Published: September 2017

AbstractThe instructive capabilities of extracellular matrix components in progenitor cell differentiation have recently generated significant interest in the development of bioinspired materials for regenerative applications. Previously, a correlation was described between the osteogenic capabilities of nanoparticulate mineralized collagen glycosaminoglycan scaffolds (MC‐GAG) and an autogenous activation of small mothers against decapentaplegic ( Smad1/5) in the canonical bone morphogenetic protein receptor (BMPR) pathway with a diminished extracellular signal regulated kinase 1/2 (ERK1/2) activation when compared to nonmineralized collagen glycosaminoglycan scaffolds (Col‐GAG). This work utilizes a canonical BMPR inhibitor (dorsomorphin homologue 1, DMH1) and an inhibitor of the mitogen activated protein kinase/ERK kinase (MEK)/(ERK) cascade (PD98059) to characterize the necessity of each pathway for osteogenesis. While DMH1 inhibits runt‐related transcription factor 2 (Runx2) and bone sialoprotein II (BSPII) gene expression of primary human mesenchymal stem cells (hMSCs) on MC‐GAG, PD98059 inhibits BSPII expression on Col‐GAG independent of Runx2 expression. DMH1 inhibits mineralization on both Col‐GAG and MC‐GAG, however, PD98059 only inhibits mineralization on Col‐GAG. DMH1 inhibits both Smad1/5 phosphorylation and Runx2 protein expression, whereas PD98059 inhibits ERK1/2 and c‐Jun amino‐terminal kinase 1/2 (JNK1/2) phosphorylation without affecting Runx2. Thus, activation of the canonical BMPR signaling is necessary for osteogenic differentiation and mineralization of hMSCs on Col‐GAG or MC‐GAG. The MEK/ERK cascade, intimately tied to JNK activation, is necessary for Runx2‐independent osteogenesis on Col‐GAG, while completely dispensable in osteogenesis on MC‐GAG.
Pro‐Regenerative Hydrogel Restores Scarless Skin during Cutaneous Wound Healing
Authors: Sun Guoming 
Published: September 2017

AbstractThe transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran‐based bioabsorbable hydrogels are developed and self‐crosslinkable dextran‐isocyanatoethyl methacrylate‐ethylamine (DexIEME) is identified as the potential scaffold. The initial screening study revealed that DexIEME has superior biocompatibility in varying concentrations. Although DexIEME brings about low proinflammatory responses, it promotes M2 macrophage phenotype. Then the optimized hydrogel formulation is tested for acute skin injuries using both murine and porcine models. Preliminary data demonstrated that the innovative DexIEME hydrogel promotes complete skin regeneration with hair regrowth on pre‐existing scars, while untreated scars remain intact. Preclinical studies further demonstrated that the DexIEME hydrogel regenerated perfect skin during deep porcine wound healing. Overall, the approach to investigate immune‐modulated hydrogels yields pro‐regenerative DexIEME hydrogel, which may lead to greater clinical success in treating deep dermal injury and attenuating scar formation.
Elastic Inflatable Actuators for Soft Robotic Applications
Authors: Gorissen Benjamin , Reynaerts Dominiek , Konishi Satoshi , Yoshida Kazuhiro , Kim Joon‐Wan , De Volder Michael 
Published: September 2017

AbstractThe 20th century's robotic systems have been made from stiff materials, and much of the developments have pursued ever more accurate and dynamic robots, which thrive in industrial automation, and will probably continue to do so for decades to come. However, the 21st century's robotic legacy may very well become that of soft robots. This emerging domain is characterized by continuous soft structures that simultaneously fulfill the role of robotic link and actuator, where prime focus is on design and fabrication of robotic hardware instead of software control. These robots are anticipated to take a prominent role in delicate tasks where classic robots fail, such as in minimally invasive surgery, active prosthetics, and automation tasks involving delicate irregular objects. Central to the development of these robots is the fabrication of soft actuators. This article reviews a particularly attractive type of soft actuators that are driven by pressurized fluids. These actuators have recently gained traction on the one hand due to the technology push from better simulation tools and new manufacturing technologies, and on the other hand by a market pull from applications. This paper provides an overview of the different advanced soft actuator configurations, their design, fabrication, and applications.
Large‐Area All‐Textile Pressure Sensors for Monitoring Human Motion and Physiological Signals
Authors: Liu Mengmeng , Pu Xiong , Jiang Chunyan , Liu Ting , Huang Xin , Chen Libo , Du Chunhua , Sun Jiangman , Hu Weiguo , Wang Zhong Lin 
Published: September 2017

AbstractWearable pressure sensors, which can perceive and respond to environmental stimuli, are essential components of smart textiles. Here, large‐area all‐textile‐based pressure‐sensor arrays are successfully realized on common fabric substrates. The textile sensor unit achieves high sensitivity (14.4 kPa−1), low detection limit (2 Pa), fast response (≈24 ms), low power consumption (<6 µW), and mechanical stability under harsh deformations. Thanks to these merits, the textile sensor is demonstrated to be able to recognize finger movement, hand gestures, acoustic vibrations, and real‐time pulse wave. Furthermore, large‐area sensor arrays are successfully fabricated on one textile substrate to spatially map tactile stimuli and can be directly incorporated into a fabric garment for stylish designs without sacrifice of comfort, suggesting great potential in smart textiles or wearable electronics.
A Simple and Efficient Method for the Preparation of α‐Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant
Authors: Tang Shi‐Zhong , Zhao Wenshuang , Chen Tao , Liu Yang , Zhang Xiao‐Ming , Zhang Fu‐Min 
Published: September 2017

Abstractα‐Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α‐halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three‐step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram‐scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments.magnified image
Molecularly imprinted polymer membrane for the removal of naphthalene from petrochemical wastewater streams
Authors: Ghasemi Sahar , Nematollahzadeh Ali 
Published: September 2017

AbstractThe aim of this work was the preparation of molecularly imprinted membrane (MiM) using polysulfone (PSf) polymer for targeted removal of polycyclic aromatic hydrocarbons from petrochemical wastewater. Naphthalene was opted as a model pollutant, and the imprinted membrane was fabricated by phase inversion technique. Nonimprinted membrane (NiM) was also prepared in the absence of naphthalene and used as a reference. The polymers (MiM/NiM) were systematically characterized using different characterization techniques. The selectivity property of the membranes was evaluated by their ability in separation of naphthalene through filtration tests. Results showed that in comparison with NiM, the imprinted membrane exhibits higher affinity toward naphthalene molecules. It was found that the selectively of MiM is 2.27‐fold more than that of the corresponding NiM. This finding can be encouraging from industrial applications points of view.
Noncovalent Functionalization and Charge Transfer in Antimonene
Authors: Abellán Gonzalo , Ares Pablo , Wild Stefan , Nuin Edurne , Neiss Christian , Miguel David Rodriguez‐San , Segovia Pilar , Gibaja Carlos , Michel Enrique G. , Görling Andreas , Hauke Frank , Gómez‐Herrero Julio , Hirsch Andreas , Zamora Félix 
Published: September 2017

AbstractAntimonene, a novel group 15 two‐dimensional material, is functionalized with a tailormade perylene bisimide through strong van der Waals interactions. The functionalization process leads to a significant quenching of the perylene fluorescence, and surpasses that observed for either graphene or black phosphorus, thus allowing straightforward characterization of the flakes by scanning Raman microscopy. Furthermore, scanning photoelectron microscopy studies and theoretical calculations reveal a remarkable charge‐transfer behavior, being twice that of black phosphorus. Moreover, the excellent stability under environmental conditions of pristine antimonene has been tackled, thus pointing towards the spontaneous formation of a sub‐nanometric oxide passivation layer. DFT calculations revealed that the noncovalent functionalization of antimonene results in a charge‐transfer band gap of 1.1 eV.
Closed Pentaaza[9]helicene and Hexathia[9]/[5]helicene: Oxidative Fusion Reactions of ortho‐Phenylene‐Bridged Cyclic Hexapyrroles and Hexathiophenes
Authors: Chen Fengkun , Tanaka Takayuki , Hong Yong Seok , Mori Tadashi , Kim Dongho , Osuka Atsuhiro 
Published: September 2017

AbstractOxidative fusion reactions of ortho‐phenylene‐bridged cyclic hexapyrroles and hexathiophenes furnished novel closed helicenes in a selective manner. X‐Ray diffraction analysis unambiguously revealed the structures to be a closed pentaaza[9]helicene, the longest azahelicene reported so far, and an unexpected double‐helical structure of hexathia[9]/[5]helicene, whose formation was assumed to result from multiple oxidative fusion along with a 1,2‐aryl shift. The pentaaza[9]helicene exhibited well‐defined emission with high fluorescence quantum yield (ΦF=0.31) among the known [9]helicenes. Chiral resolution of the racemic pentaaza[9]helicene and hexathia[9]/[5]helicene were achieved by chiral‐phase HPLC and the enantiomers were characterized by circular dichroism spectra and DFT calculations.
Epitaxial Growth of Hetero‐Ln‐MOF Hierarchical Single Crystals for Domain‐ and Orientation‐Controlled Multicolor Luminescence 3D Coding Capability
Authors: Pan Mei , Zhu Yi‐Xuan , Wu Kai , Chen Ling , Hou Ya‐Jun , Yin Shao‐Yun , Wang Hai‐Ping , Fan Ya‐Nan , Su Cheng‐Yong 
Published: September 2017

AbstractCore–shell or striped heteroatomic lanthanide metal–organic framework hierarchical single crystals were obtained by liquid‐phase anisotropic epitaxial growth, maintaining identical periodic organization while simultaneously exhibiting spatially segregated structure. Different types of domain and orientation‐controlled multicolor photophysical models are presented, which show either visually distinguishable or visible/near infrared (NIR) emissive colors. This provides a new bottom‐up strategy toward the design of hierarchical molecular systems, offering high‐throughput and multiplexed luminescence color tunability and readability. The unique capability of combining spectroscopic coding with 3D (three‐dimensional) microscale spatial coding is established, providing potential applications in anti‐counterfeiting, color barcoding, and other types of integrated and miniaturized optoelectronic materials and devices.
A Highly Reactive Oxoiron(IV) Complex Supported by a Bioinspired N3O Macrocyclic Ligand
Authors: Monte Pérez Inés , Engelmann Xenia , Lee Yong‐Min , Yoo Mi , Kumaran Elumalai , Farquhar Erik R. , Bill Eckhard , England Jason , Nam Wonwoo , Swart Marcel , Ray Kallol 
Published: September 2017

AbstractThe sluggish oxidants [FeIV(O)(TMC)(CH3CN)]2+ (TMC=1,4,8,11‐tetramethyl‐1,4,8,11‐tetraazacyclotetradecane) and [FeIV(O)(TMCN‐d12)(OTf)]+ (TMCN‐d12=1,4,7,11‐tetra(methyl‐d3)‐1,4,7,11‐tetraazacyclotetradecane) are transformed into the highly reactive oxidant [FeIV(O)(TMCO)(OTf)]+ (1; TMCO=4,8,12‐trimethyl‐1‐oxa‐4,8,12‐triazacyclotetradecane) upon replacement of an NMe donor in the TMC and TMCN ligands by an O atom. A rate enhancement of five to six orders of magnitude in both H atom and O atom transfer reactions was observed upon oxygen incorporation into the macrocyclic ligand. This finding was explained in terms of the higher electrophilicity of the iron center and the higher availability of the more reactive S=2 state in 1. This rationalizes nature's preference for using O‐rich ligand environments for the hydroxylation of strong C−H bonds in enzymatic reactions.
A Zwitterionic, 10 π Aromatic Hemisphere
Authors: Hafezi Nema , Shewa Wondimagegn T. , Fettinger James C. , Mascal Mark 
Published: September 2017

AbstractA new concept in anionic 10 π aromaticity is described by the embedding of a compensating charge within an aromatic cyclononatetraenide ring by the symmetric superposition of an alkyl ammonium bridge. This is accomplished by the methylation of azatriquinacene to give a quaternary ammonium salt, followed by oxidation to the tetraene and final deprotonation. The resulting zwitterion is a stable [9]annulene with strong aromaticity as shown by its degree of C−C bond equalization and a nucleus‐independent chemical shift value lower than that of benzene. The solid‐state structure shows an eclipsed stacking motif with the electron‐poor ammonium methyl groups occupying the electron‐rich cavity of the aromatic bowl.
Iron(III) porphyrin catalyzed ionic liquid mediated polymerization of methylmethacrylate
Authors: Singhal Anchal , Ahmad Sohail , Chauhan Shive M.S. 
Published: September 2017

A novel application of iron(III)porphyrin catalyst, 5,10,15,20 − tetrakis − (2′,6′‐dichlorophenyl)porphyrinatoiron(III) chloride is reported for the reaction of methyl methacrylate with hydrogen peroxide in imidazolium ionic liquids at ambient temperature. The reaction furnished polymethyl methacrylate in 75–94% yields. The yield of the polymer was optimized upon changing the reaction media, ratio of catalyst, oxidant and substrate, reaction time and quenchers. The polymethyl methacrylate was secured as highly stereoregular with predominantly syndiotactic sequences as analyzed with the aid of NMR (1H and 13C) and infrared spectroscopy. Besides, the number‐average molecular weights (Mn) were attained in the range of 15,000 to 55,000 with narrow polydispersity (~1.1–1.9) as calculated using gel permeable chromatography (GPC).
Green synthesis of silver nanoparticles using water extract of Salvia leriifolia: Antibacterial studies and applications as catalysts in the electrochemical detection of nitrite
Authors: Baghayeri Mehdi , Mahdavi Behnam , Hosseinpor‐Mohsen Abadi Zahra , Farhadi Samaneh 
Published: September 2017

Here, a green method is described for the biosynthesis of Ag nanoparticles (Ag NPs) using aqueous extracts of the leaf of Salvia leriifolia as reducing and stabilizing agent. Various techniques such as scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM) and X‐ray diffraction (XRD) were employed for the characterization of the structure and morphology of bio‐synthesized AgNPs. The results reveal that AgNPs synthesized with uniform spherical morphology and average diameters of 27 nm. The AgNPs as a green and efficient heterogeneous catalyst presented superior antibacterial activity. Direct electrochemistry studies of the synthesized AgNPs confirmed that nanoparticles retained their direct electrochemical activity. This is mainly attributed to the proper biosynthesis process, the large specific surface area and the good conductivity of the synthesized nanoparticles. Hence, the present synthesized AgNPs displayed good electrocatalytic activity to the reduction of nitrite ions. The proposed method is highly recommended as a novel platform for the development of electrochemical sensors which can further expand the applications of AgNPs. Antibacterial activity of the synthesized AgNPs was evaluated against nine microorganisms. AgNPs prevented the growth of all selected bacteria. The nanoparticles inhibited the growth of Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus coagulase, Acinetobacter baumannii, and Streptococcus pneumonia more than antibiotic of vancomycin, however, the ability of AgNPs against Echerishia coli and Serratia marcescens was less than the antibiotic. On the other hand AgNPs were active against Citrobacter frurdii, while the antibiotic was inactive.
Effect of Ca2+ induced crosslinking on the mechanical and barrier properties of cast alginate films
Authors: Jost Verena , Reinelt Matthias 
Published: September 2017

ABSTRACTThe use of alginate as a coating material for packaging applications is currently limited due to its difficult processability and high moisture sensitivity. Therefore, this study addresses the crosslinking and scale‐up to a continuous application. Three different crosslinking agents were applied: CaCl2 with ethylene diamine tetraacetic acid and two low soluble salts (CaHPO4 and CaCO3). Those were incorporated by internal setting in an alginate matrix with varying Ca2+ concentration (
) and ratio. With the addition of Ca2+, the tensile strength and elongation at break of the cast alginate films increased. This was optimal for a
of 0.010–0.015 g (g alginate)−1 dependent on the crosslinking agent. The decrease in water vapor and oxygen permeability due to crosslinking was independent of the crosslinking agent. However, the optimal
aiming to decrease permeability was different for the crosslinking agents: CaHPO4 showed best results at a
of 0.010 g (g alginate)−1, CaCl2 at 0.012 g (g alginate)−1, and CaCO3 at 0.027 g (g alginate)−1. Upon all analyzed properties CaHPO4 was the most promising crosslinking agent for alginate. Moreover, selected alginate formulations were successfully processed in a continuous lacquering plant. The produced two‐layer systems have very low oxygen permeabilities which can be further reduced by crosslinking. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45754.
Preparation and property of starch nanoparticles reinforced aldehyde–hydrazide covalently crosslinked PNIPAM hydrogels
Authors: Li Shanshan , Xia Yuzheng , Qiu Yang , Chen Xiaonong , Shi Shuxian 
Published: September 2017

ABSTRACTInjectable, de‐crosslinkable, and thermosensitive hydrogels are obtained by hydrazide‐functionalized poly(N‐isopropylacrylamide) and aldehyde‐functionalized dextrin through in situ crosslinked method. Natural based and degradable starch nanoparticles (SNPs) are used as fillers in order to improve mechanical property of hydrogels. Internal morphology, dynamic modulus, thermosensitivity property, de‐crosslinking performance, drug release, and in vitro cytotoxicity of hydrogels are investigated. Results show that SNPs disperse well throughout hydrogel and have no significant influence on gelation time and de‐crosslinking performance. Elasticity property of composite hydrogel prepared from 9.0 wt % precursors with 1.5 wt % fillers is improved significantly by SNPs and maximum storage modulus reaches 399.2 kPa, but 89.6 kPa of unreinforced hydrogels. Hydrogels exhibit good thermosensitive performance at alternating cyclic temperature of 25 and 37 °C. Doxorubicin hydrochloride‐loaded hydrogels can release more than 25 days. No significant cytotoxicity to L929 fibroblast cells is observed through a CCK‐8 assay for hydrogels, precursors, and SNPs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45761.
Tailoring terpenoid plasma polymer properties by controlling the substrate temperature during PECVD
Authors: Kumar Avishek , Grant Daniel S. , Bazaka Kateryna , Jacob Mohan V. 
Published: September 2017

ABSTRACTPolymers derived from natural, minimally‐processed materials have recently emerged as a more sustainable alternative to synthetic polymers, with promising applications in biocompatible and biodegradable devices. Plasma‐enhanced deposition is well‐suited to one‐step, fast, and efficient synthesis of highly crosslinked inert polymers directly from natural resources, however, fabrication of biologically active polymers remains a challenge. Plasma processing parameters influence the properties such as surface energy, roughness, morphology, and chemical composition of deposited polymers and thus their final applications. This article reports on the important role of substrate temperature (TS) in the chemical composition, wettability, refractive index, and crosslinking density of plasma polymers derived from terpenoids. Experiments are conducted as a function of deposition power Pd, and substrate temperature, TS. TS varied from 40 to 280 °C and is externally controlled. Atomic force microscopy analysis reveals the change in deposition mechanism attributed to shadowing effect at higher TS and Pd. Increase in band gap (Eg) with high Ts deposition for terpenoid based plasma polymers is observed. Swelling behavior analyzed by in situ ellipsometry affirms the enhanced crosslink density with increasing deposition rate. Fourier transform infrared analysis exhibits the formation of additional chemical moieties with increasing TS. Increase in deposition rate with increasing TS at higher Pd supports the theory of direct incorporation of depositing particles as dominant mechanism of plasma polymerization in this study. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45771.
Morphological, mechanical, and thermal features of PMMA nanocomposites containing two‐dimensional Co–Al layered double hydroxide
Authors: Kumar Manish , Chakraborty Samarshi , Upadhyaya Pradeep , Pugazhenthi G. 
Published: September 2017

ABSTRACTThe focus of the current study is to investigate the influence of Co–Al layered double hydroxide (LDH) on the morphological, thermal, and mechanical features of poly(methyl methacrylate) (PMMA)‐based nanocomposites. Sodium dodecyl sulfate modified Co–Al LDH was synthesized by single step coagulation method. The PMMA nanocomposites containing different loadings of nanofiller (1–7 wt %) and polystyrene‐grafted maleic anhydride compatibilizer (5 wt %) were melt intercalated via twin screw extruder and later subjected to injection molding to prepare mechanical testing samples. The different properties of PMMA nanocomposites were studied by using XRD, TEM, FTIR, DSC, TGA, tensile, flexural, impact, and flammability analysis. The result of XRD analysis suggested the exfoliated morphology of the nanocomposite while the TEM demonstrated the intercalated structure at higher loading of LDH. The thermal characterization results revealed that thermal properties were improved by the addition of Co–Al LDH, whereas the flammability test exposed that dripping was minimum at 7 wt % loading. The mechanical properties exhibited that optimum results were obtained at 1 wt % loading of Co–Al LDH. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45774.