bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erratum: Annual community patterns are driven by seasonal switching between closely related marine bacteria
Authors: Ward Christopher S , Yung Cheuk-Man , Davis Katherine M , Blinebry Sara K , Williams Tiffany C , Johnson Zackary I , Hunt Dana E 
Published: October 2017

Abstract
Correction to: The ISME Journal 2017; 11: 1412−1422. doi: 10.1038/ismej.2017.4 In the original online publication of this article the incorrect file was uploaded as supplementary information. The correct file has now been added to the online version of the article. The publishers would like to apologise for this error.
Functional Role of Cyclin-Dependent Kinase 5 in the Regulation of Melanogenesis and Epidermal Structure
Authors: Dong Changsheng , Yang Shanshan , Fan Ruiwen , Ji Kaiyuan , Zhang Junzhen , Liu Xuexian , Hu Shuaipeng , Xie Jianshan , Liu Yu , Gao Wenjun , Wang Haidong , Yao Jianbo , Smith George W , Herrid Muren 
Published: October 2017

AbstractThe mammalian integumentary system plays important roles in body homeostasis, and dysfunction of melanogenesis or epidermal development may lead to a variety of skin diseases, including melanoma. Skin pigmentation in humans and coat color in fleece-producing animals are regulated by many genes. Among them, microphthalmia-associated transcription factor (MITF) and paired-box 3 (PAX3) are at the top of the cascade and regulate activities of many important melanogenic enzymes. Here, we report for the first time that cyclin-dependent kinase 5 (Cdk5) is an essential regulator ofMITFandPAX3.Cdk5knockdown in mice causes a lightened coat color, a polarized distribution of melanin and hyperproliferation of basal keratinocytes. Reduced expression of Keratin 10 (K10) resulting fromCdk5knockdown may be responsible for an abnormal epidermal structure. In contrast, overexpression ofCdk5in sheep (Ovis aries) only produces brown patches on a white background, with no other observable abnormalities. Collectively, our findings show that Cdk5 has an important functional role in the regulation of melanin production and transportation and in normal development of the integumentary system.
Effect of random feld disorder on topological superconductors
Authors: Zhou Tao 
Published: October 2017

AbstractWe study the effect of random field disorder on two dimensional topological superconductors based on the Bogoliubov-de Gennes equations. A phase transition from the phase coherent state to the disordered state is identified numerically. The two phases can be characterized by two different correlation functions. In the phase coherent state, Majorana Fermion states form and may be influenced by the interaction between the vortex and the antivortex. The local density of states is calculated, which may be used to distinguish these two phases.
Compared to self-immersion, mindful attention reduces salivation and automatic food bias
Authors: Baquedano Constanza , Vergara Rodrigo , Lopez Vladimir , Fabar Catalina , Cosmelli Diego , Lutz Antoine 
Published: October 2017

AbstractImmersing ourselves in food images can sometimes make it feel subjectively real, as if the actual food were right in front of us. Excessive self-immersion into mental content, however, is a hallmark of psychological distress, and of several psychiatric conditions. Being aware that imagined events are not necessarily an accurate depiction of reality is a key feature of psychotherapeutic approaches akin to mindfulness-based interventions. Yet, it is still largely unknown to what extent one’s engagement with mental content, considering it as real, biases one’s automatic tendencies toward the world. In this study, we measured the change in subjective realism induced by a self-immersion and a mindful attention instruction, using self-reports and saliva volumes. Then, we measured behaviorally the impact of subjective realism changes on automatic approach bias toward attractive food (FAB) using an approach–avoidance task. We found a reduction in saliva volume, followed by a reduction in FAB in the mindful condition compared to the immersed condition. During the immersed condition only, saliva volumes, state and trait measures of subjective realism, and food craving traits were positively correlated with FAB values, whereas meditation experience was negatively correlated to it. We conclude that mindful attention instructions can de-automatize food bias.
Coherent Structure Formation through nonlinear interactions in 2D Magnetohydrodynamic Turbulence
Authors: De Giorgio Elisa , Servidio Sergio , Veltri Pierluigi 
Published: October 2017

AbstractUsing high resolution 2D magnetohydrodynamic (MHD) simulations we analyze the formation of coherent structures induced by nonlinear interactions in turbulent flows. The properties of these coherent structures, which at the smallest scales are identified through a spatial intermittent behavior, turn out to be guided by the conservation of ideal quadratic (rugged) invariants of the 2D incompressible MHD equations. Different spatial regions can be identified, where the correlations predicted using the variational principles associated to the rugged invariants are locally displayed. These local correlated structures are produced rapidly, as soon as the turbulence is fully developed. It is worth speculating that the small scale structures under our investigation could give rise to singular weak solutions when letting the dissipative coefficients go to zero. In this case their properties could furnish a key to understand which mathematical conditions characterize singularity emergency in weak solutions of the MHD ideal case.
Synthesis of Reduced Grapheme Oxide as A Platform for loading β-NaYF4:Ho3+@TiO2Based on An Advanced Visible Light-Driven Photocatalyst
Authors: Fan Zihong , Wu Tianhui , Xu Xuan 
Published: October 2017

AbstractIn this paper a novel visible light-driven ternary compound photocatalyst (β-NaYF4:Ho3+@TiO2-rGO) was synthesized using a three-step approach. This photocatalyst was characterized using X-ray diffraction, Raman scattering spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Transmission electron microscopy, X-ray photoelectron spectroscopy, fluorescence spectrometries, ultraviolet-visible diffuse reflectance spectroscopy, Brunauer–Emmett–Teller surface area measurement, electron spin resonance, three-dimensional fluorescence spectroscopy, and photoelectrochemical properties. Such proposed photocatalyst can absorb 450 nm visible light while emit 290 nm ultraviolet light, so as to realize the visible light-driven photocatalysis of TiO2. In addition, as this tenary compound photocatalyst enjoys effecitve capacity of charge separation, superior durability, and sound adsorb ability of RhB, it can lead to the red shift of wavelength of absorbed light. This novel tenary photocatalyst can reach decomposition rate of RhB as high as 92% after 10 h of irradiation by visible-light Xe lamp. Compared with the blank experiment, the efficiency was significantly improved. Recycle experiments showed that theβ-NaYF4:Ho3+@TiO2-rGOcomposites still presented significant photocatalytic activity after four successive cycles. Finally, we investigated visible-light-responsive photocatalytic mechanism of the β-NaYF4:Ho3+@TiO2-rGO composites. It is of great significance to design an effective solar light-driven photocatalysis in promoting environmental protection.
Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth
Authors: Achyut B. R. , Angara Kartik , Jain Meenu , Borin Thaiz F. , Rashid Mohammad H. , Iskander A. S. M. , Ara Roxan , Kolhe Ravindra , Howard Shelby , Venugopal Natasha , Rodriguez Paulo C. , Bradford Jennifer W. , Arbab Ali S. 
Published: October 2017

AbstractTumor development and therapeutic resistance are linked with tumor-associated macrophage (TAM) and myeloid-derived suppressor cell (MDSC) infiltration in tumors via chemokine axis. Chemokine expression, which determines the pro or anti-inflammatory status of myeloid cells, are partly regulated by the nuclear factor-kappa B (NF-κB) pathway. Here, we identified that conditional deletion of canonical NF-κB signaling (p65) in myeloid cells inhibited syngeneic glioblastoma (GBM) through decreased CD45 infiltration in tumors, as characterized by decreased TAMs (CD206+) and MDSCs (Gr1+ CD11b+), increased dendritic cells (CD86+) and cytotoxic T cells (CD8+) in the p65 knockout (KO) mice. Proinflammatory cytokines (IFNγ, MCP1, MIP1α, and TNFα) and myeloid differentiation factor (Endoglin) were increased in myeloid cells from p65 KO tumor, which demonstrated an influence on CD8+T cell proliferation. In contrast, p65KO athymic chimeric mice with human GBM, failed to inhibit tumor growth, confirming the contribution of T cells in an immune competent model. The analysis of human datasets and GBM tumors revealed higher expression of p65 in GBM-associated CD68+ macrophages compared to neighboring stroma. Thus, canonical NF-κB signaling has an anti-inflammatory role and is required for macrophage polarization, immune suppression, and GBM growth. Combining an NF-κB inhibitor with standard therapy could improve antitumor immunity in GBM.
Improved detection of BRAF V600E using allele-specific PCR coupled with external and internal controllers
Authors: Yang Zhao , Zhao Na , Chen Dong , Wei Kun , Su Ning , Huang Jun-Fu , Xu Han-Qing , Duan Guang-Jie , Fu Wei-Ling , Huang Qing 
Published: October 2017

AbstractAlthough traditional allele-specific PCR (tAS-PCR) is a common screening method for BRAF V600E mutations, its lower amplification specificity and mutation selectivity have limited its clinical applications. We hypothesize that these limitations are associated with the weaker specificities of allele-specific primers and the thermodynamic driving forces of DNA polymerase. We used three strategies to circumvent these limitations, namely, modifying allele-specific primers, introducing a competitive external allele-specific controller (i.e., cAS-PCR), and introducing a referenced internal positive controller in the cAS-PCR (i.e., rcAS-PCR). The amplification sensitivities and specificities were influenced by the position of the artificially introduced mismatched nucleotide in the allele-specific primers. Moreover, both cAS-PCR and rcAS-PCR could detect single-copy BRAF V600E alleles with higher mutation selectivity (0.1%) than tAS-PCR. In addition, cAS-PCR eliminated false-negative results caused by various PCR inhibitors that might be present in the DNA solutions. The rcAS-PCR could also be employed to avoid the false-negative results caused by low-abundance input templates in cAS-PCR. In conclusion, rcAS-PCR provides a rapid, simple, and low-cost method for detecting low levels of the mutated BRAF V600E gene.
Propensity-score-matched evaluation of the incidence of radiation pneumonitis and secondary cancer risk for breast cancer patients treated with IMRT/VMAT
Authors: Chao Pei-Ju , Lee Hsiao-Fei , Lan Jen-Hong , Guo Shih-Sian , Ting Hui-Min , Huang Yu-Jie , Chen Hui-Chun , Lee Tsair-Fwu 
Published: October 2017

AbstractPropensity score matching evaluates the treatment incidence of radiation-induced pneumonitis (RP) and secondary cancer risk (SCR) after intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for breast cancer patients. Of 32 patients treated with IMRT and 58 who received VMAT were propensity matched in a 1:1 ratio. RP and SCR were evaluated as the endpoints of acute and chronic toxicity, respectively. Self-fitted normal tissue complication probability (NTCP) parameter values were used to analyze the risk of RP. SCRs were evaluated using the preferred Schneider’s parameterization risk models. The dosimetric parameter of the ipsilateral lung volume receiving 40 Gy (IV40) was selected as the dominant risk factor for the RP NTCP model. The results showed that the risks of RP and NTCP, as well as that of SCR of the ipsilateral lung, were slightly lower than the values in patients treated with VMAT versus IMRT (p ≤ 0.01). However, the organ equivalent dose and excess absolute risk values in the contralateral lung and breast were slightly higher with VMAT than with IMRT (p ≤ 0.05). When compared to IMRT, VMAT is a rational radiotherapy option for breast cancer patients, based on its reduced potential for inducing secondary malignancies and RP complications.
Thermally stable amorphous tantalum yttrium oxide with low IR absorption for magnetophotonic devices
Authors: Yoshimoto Takuya , Goto Taichi , Takagi Hiroyuki , Nakamura Yuchi , Uchida Hironaga , Ross Caroline A. , Inoue Mitsuteru 
Published: October 2017

AbstractThin film oxide materials often require thermal treatment at high temperature during their preparation, which can limit them from being integrated in a range of microelectronic or optical devices and applications. For instance, it has been a challenge to retain the optical properties of Bragg mirrors in optical systems at temperatures above 700 °C because of changes in the crystalline structure of the high–refractive-index component. In this study, a ~100 nm–thick amorphous film of tantalum oxide and yttrium oxide with an yttrium-to-tantalum atomic fraction of 14% was prepared by magnetron sputtering. The film demonstrated high resistance to annealing above 850 °C without degradation of its optical properties. The electronic and crystalline structures, stoichiometry, optical properties, and integration with magnetooptical materials are discussed. The film was incorporated into Bragg mirrors used with iron garnet microcavities, and it contributed to an order-of-magnitude enhancement of the magnetooptical figure of merit at near-infrared wavelengths.
A Maternal Two-meal Feeding Sequence with Varying Crude Protein Affects Milk Lipid Profile in A Sow-Piglet Model
Authors: Wu Xin , Xie Chunyan , Guo Xiaoyun , Long Cimin , Zhang Tianyong , Gao Tianzeng , Yin Yulong 
Published: October 2017

AbstractThe effects of a two-meal feeding sequence on production performance and milk lipid profile were investigated. Sixty pregnant sows (d 85 of gestation) were assigned to 3 groups: 2 C group (fed a control crude protein [CP] diet at 0600 and 1500 daily), LH group (fed a low CP diet and a high CP diet at 0600 and 1500), or HL group (fed a high CP diet and a low CP diet at 0600 and 1500). Reproductive performance of sows, and lipid profiles of plasma and milk were measured. Results showed that the HL feeding sequence dramatically increased average piglet weight/litter, average daily gain of piglet/litter, and milk production of sows. LH feeding sequence increased milk fat proportion, and HL feeding sequence significantly increased the proportion of milk MUFA on d 14 and 21 of lactation. Interestingly, the HL feeding sequence also reduced the ratio of C18:1
cis
/C18:1
trans
in milk, which may account for the greater milk production of sows and growth performance of piglets during lactation. These findings indicated that both the maternal two-meal feeding sequences with varying crude protein improved milk production and milk lipid profiles of sows, which might contribute to improving growth performance of piglets.
CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease
Authors: Koch Giacomo , Di Lorenzo Francesco , Loizzo Stefano , Motta Caterina , Travaglione Sara , Baiula Monica , Rimondini Roberto , Ponzo Viviana , Bonnì Sonia , Toniolo Sofia , Sallustio Fabrizio , Bozzali Marco , Caltagirone Carlo , Campana Gabriele , Martorana Alessandro 
Published: October 2017

AbstractIn Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanism invokes the dysfunction of synaptic plasticity. We investigated how CSF tau interacts with APOE genotype in AD patients. We firstly explored whether CSF tau levels and APOE genotype influence disease progression and long-term potentiation (LTP)-like cortical plasticity as measured by transcranial magnetic stimulation (TMS) in AD patients. Then, we incubated normal human astrocytes (NHAs) with CSF collected from sub-groups of AD patients to determine whether APOE genotype and CSF biomarkers influence astrocytes survival. LTP-like cortical plasticity differed between AD patients with apolipoprotein E4 (APOE4) and apolipoprotein E3 (APOE3) genotype. Higher CSF tau levels were associated with more impaired LTP-like cortical plasticity and faster disease progression in AD patients with APOE4 but not APOE3 genotype. Apoptotic activity was higher when cells were incubated with CSF from AD patients with APOE4 and high tau levels. CSF tau is detrimental on cortical plasticity, disease progression and astrocyte survival only when associated with APOE4 genotype. This is relevant for new therapeutic approaches targeting tau.
Facile synthesis and emission enhancement in NaLuF4 upconversion nano/micro-crystals via Y3+ doping
Authors: Lin Hao , Xu Dekang , Li Anming , Yao Lu , Qiu Zhiren , Yang Shenghong , Zhang Yueli 
Published: October 2017

AbstractA series of Y3+-absent/doped NaLuF4:Yb3+, Tm3+ nano/micro-crystals were prepared via a hydrothermal process with the assistance of citric acid. Cubic nanospheres, hexagonal microdisks, and hexagonal microprisms can be achieved by simply adjusting the reaction temperature. The effect of Y3+ doping on the morphology and upconversion (UC) emission of the as-prepared samples were systematically investigated. Compared to their Y3+-free counterpart, the integrated spectral intensities in the range of 445–495 nm from α-, β-, and α/β-mixed NaLuF4:Yb3+, Tm3+ crystals with 40 mol% Y3+ doping are increased by 9.7, 4.4, and 24.3 times, respectively; red UC luminescence intensities in the range of 630–725 nm are enhanced by 4.6, 2.4, and 24.9 times, respectively. It is proposed that the increased UC emission intensity is mainly ascribed to the deformation of crystal lattice, due to the electron cloud distortion in host lattice after Y3+ doping. This paper provides a facile route to achieve nano/micro-structures with intense UC luminescence, which may have potential applications in optoelectronic devices.
An automated method for identifying an independent component analysis-based language-related resting-state network in brain tumor subjects for surgical planning
Authors: Lu Junfeng , Zhang Han , Hameed N. U. Farrukh , Zhang Jie , Yuan Shiwen , Qiu Tianming , Shen Dinggang , Wu Jinsong 
Published: October 2017

AbstractAs a noninvasive and “task-free” technique, resting-state functional magnetic resonance imaging (rs-fMRI) has been gradually applied to pre-surgical functional mapping. Independent component analysis (ICA)-based mapping has shown advantage, as noa prioriinformation is required. We developed an automated method for identifying language network in brain tumor subjects using ICA on rs-fMRI. In addition to standard processing strategies, we applied a discriminability-index-based component identification algorithm to identify language networks in three different groups. The results from the training group were validated in an independent group of healthy human subjects. For the testing group, ICA and seed-based correlation were separately computed and the detected language networks were assessed by intra-operative stimulation mapping to verify reliability of application in the clinical setting. Individualized language network mapping could be automatically achieved for all subjects from the two healthy groups except one (19/20, success rate = 95.0%). In the testing group (brain tumor patients), the sensitivity of the language mapping result was 60.9%, which increased to 87.0% (superior to that of conventional seed-based correlation [47.8%]) after extending to a radius of 1 cm. We established an automatic and practical component identification method for rs-fMRI-based pre-surgical mapping and successfully applied it to brain tumor patients.
A Novel Visceral Adiposity Index for Prediction of Type 2 Diabetes and Pre-diabetes in Chinese adults: A 5-year prospective study
Authors: Wu Jinshan , Gong Lilin , Li Qifu , Hu Jinbo , Zhang Shuping , Wang Yue , Zhou Huang , Yang Shuming , Wang Zhihong 
Published: October 2017

AbstractThe Chinese visceral adiposity index (CVAI) is a recently developed indicator of visceral adiposity. We investigated the predictive value of the CVAI for the development of dysglycemia (pre-diabetes and type 2 diabetes) and compared its predictive power with that of the Visceral adiposity index (VAI) and various anthropometric indices. This community-based study included 2,383 participants. We assessed the predictive power of adiposity indices by performing univariate and multivariate binary logistic regression analysis and calculating the area under the receiver-operating characteristic (ROC) curve according to their quartiles. Logistic regression analysis showed that individuals in higher CVAI quartiles at baseline were more likely to develop dysglycemia than those in lower CVAI quartiles. The area under the ROC curve for CVAI was significantly higher than that of other adiposity indices. In addition, among the various adiposity indices tested, the CVAI had the greatest Youden index for identifying dysglycemia in both genders. Our data demonstrate that the CVAI is a better predictor of type 2 diabetes and pre-diabetes than the VAI, BMI, waist circumference, waist-to-hip ratio and waist-to-height ratio in Chinese adults.
Photonics-based real-time ultra-high-range-resolution radar with broadband signal generation and processing
Authors: Zhang Fangzheng , Guo Qingshui , Pan Shilong 
Published: October 2017

AbstractReal-time and high-resolution target detection is highly desirable in modern radar applications. Electronic techniques have encountered grave difficulties in the development of such radars, which strictly rely on a large instantaneous bandwidth. In this article, a photonics-based real-time high-range-resolution radar is proposed with optical generation and processing of broadband linear frequency modulation (LFM) signals. A broadband LFM signal is generated in the transmitter by photonic frequency quadrupling, and the received echo is de-chirped to a low frequency signal by photonic frequency mixing. The system can operate at a high frequency and a large bandwidth while enabling real-time processing by low-speed analog-to-digital conversion and digital signal processing. A conceptual radar is established. Real-time processing of an 8-GHz LFM signal is achieved with a sampling rate of 500 MSa/s. Accurate distance measurement is implemented with a maximum error of 4 mm within a range of ~3.5 meters. Detection of two targets is demonstrated with a range-resolution as high as 1.875 cm. We believe the proposed radar architecture is a reliable solution to overcome the limitations of current radar on operation bandwidth and processing speed, and it is hopefully to be used in future radars for real-time and high-resolution target detection and imaging.