bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin suppresses cell viability in breast cancer cell line by affecting the expression of miR-15a-5p
Authors: Suer Ilknur , Abuaisha Asmaa , Kaya Murat , Abanoz Fahrunnisa , Cefle Kivanc , Palanduz Sukru , Ozturk Sukru 
Published: September 2024

Abstract

Objectives
Curcumin plays a leading role as an epigenetic regulator in cancer. miR-15a-5p is a crucial non-coding RNA for breast cancer (BRCA) and various cancers due to its tumor suppressor role. In our study, we aimed to examine the curcumin/miR-15a-5p/target gene interaction in BRCA cells.

Methods
The effects of curcumin and miR-15a-5p on cell viability in the MCF7 cells were examined using the WST8 technique. The cell migration was determined using scratch wound assay. miR-15a-5p level was detected in curcumin-treated cells and miR-15a-5p transfected cells compared to control groups by RT-qPCR. Overexpressed genes in BRCA were found by bioinformatics tools (GSE41970 and TCGA). miR15a-5p potential target genes in the miRNet tool were selected in overlapped genes between GSE41970 and TCGA. Survival analysis of the selected genes was examined using the GEPIA2 tool. Relative expression levels of four selected genes were examined via qPCR.

Results
Cell viability and scratch-wound closure rate were reduced in curcumin-treated and miR-15a-5p mimic transfected MCF7 cells. miR15a-5p overexpressed in curcumin-treated and miR-15a-5p transfected cells. Eighty-three dysregulated upregulated genes were detected (in GSE41970 and TCGA). Among the possible target genes of miR-15a-5p in the miRNet tool, 10 upregulated genes were detected overlapping with GSE41970 and TCGA. CCNE1 and CHEK1 genes were found to be important for survival in BRCA. CCNE1 and BMI1 were decreased in curcumin-treated and miR-15a-5p transfected cells.

Conclusions
Curcumin treatment increased miR-15a-5p and downregulated selected target genes. Curcumin/miR-15a-5p interaction may be a much stronger negative regulator of the CCNE1 and BMI1 genes in BRCA.
Potential Bias in Social Work Consultations in the Pediatric Inpatient Setting
Authors: Segev Natalie R. , Fanta Meghan L. , Litman Stacey , Beck Andrew F. , Unaka Ndidi I. 
Published: September 2024

BACKGROUND AND OBJECTIVES
Failure to thrive, brief resolved unexplained event, accidental ingestion, and drowning admissions commonly involve social work (SW) consultation. Care team biases likely influence SW consultation decisions. We examined whether SW consultations varied by patient race for these diagnoses.

METHODS
We conducted a retrospective cohort study of children &lt;6 years of age admitted for failure to thrive, brief resolved unexplained event, accidental ingestion, and drowning between July 1, 2012 and June 30, 2020 at a single, academic, standalone children’s hospital in an urban environment. The outcome was SW consultation; the predictor was patient race. We used multivariable logistic regression, adjusting for ethnicity, language, insurance, and diagnosis. We completed a supplemental chart review of a random sample of 10% of patients with SW consultation to determine the reasons that consultations were placed.

RESULTS
We included 1199 unique patients; 64% identified as white, and 22% identified as Black. Black patients had 1.61 times higher adjusted odds of SW consultation compared with white patients (95% confidence interval 1.14–2.29). Publicly insured, compared with privately insured, patients had 6.10 times higher adjusted odds of SW consultation (95% confidence interval 4.28–8.80). Upon supplemental chart review, Black patients had SW consultations that focused more often on abuse, neglect, and safety; this was also found for publicly insured patients. There was parity in consultation for resource needs across groups.

CONCLUSIONS
Black children were more likely than white children to receive SW consultation during hospitalization, as were publicly insured children compared with their privately insured peers; in supplemental review, this was not due to differences in consultations for resource needs. The standardization of SW consultation may promote equitable care.
Identifikasi kontaminasi Salmonella sp. pada ikan cakalang (Katsuwonus pelamis) di Pasar Ikan Kedonganan
Authors: Kusuma Baruna Bagus Putra , Pinatih Komang Januartha Putra , Darwinata Agus Eka , Tarini Ni Made Adi 
Published: September 2024

Background: Food contamination can be a serious health problem. This contamination can occur in various places, one of which is traditional markets. Raw food, including skipjack tuna (Katsuwonus pelamis), is one of the food ingredients that is at risk of contamination due to improper handling. Several sources say that significant contamination in skipjack tuna can come from Salmonella sp. which can contribute to various disease complications. Evaluation and identification of Salmonella sp contamination. on skipjack tuna at the Kedonganan Fish Market, Bali is an important thing to review further.
Method A cross-sectional approach was carried out to identify Salmonella sp. contamination in skipjack tuna at the Kedonganan Fish Market. Data was taken from samples obtained using the cluster random sampling method, then tested for Triple Sugar Iron Agar (TSIA) and analyzed descriptively.
Results: Of the 20 samples that were collected, 6 samples (30%) of skipjack tuna were identified as being contaminated with Salmonella sp. which was marked by a positive Triple Suger Iron test.
Conclusion: Salmonella sp. contamination was found in skipjack tuna meat sold at the Kedonganan Fish Market with a contamination prevalence of 30%.

Latar Belakang : Kontaminasi makanan dapat menjadi permasalahan yang serius terhadap kesehatan. Kontaminasi tersebut dapat terjadi di berbagai tempat, salah satunya adalah pasar tradisional. Makanan mentah, termasuk daging ikan cakalang (Katsuwonus pelamis), menjadi salah satu bahan makanan yang berisiko mengalami kontaminasi akibat penanganan yang tidak tepat. Beberapa sumber menyebutkan bahwa kontaminasi signifikan pada ikan cakalang dapat berasal dari Salmonella sp. yang dapat berkontribusi terhadap berbagai komplikasi penyakit. Evaluasi dan identifikasi dari kontaminasi Salmonella sp. pada ikan cakalang di Pasar Ikan Kedonganan, Bali merupakan hal penting untuk ditinjau lebih lanjut.
Metode : Pendekatan potong lintang dilakukan untuk mengidentifikasi kontaminasi Salmonella sp pada ikan cakalang di Pasar Ikan Kedonganan. Data diambil dari sampel yang diperoleh dengan metode cluster random sampling kemudian dilakukan pengujian Triple Sugar Iron Agar (TSIA) dan dianalisis secara deskriptif.
Hasil : Dari 20 sampel yang telah dikumpulkan, ditemukan teridentifikasi sebanyak 6 sampel (30%) ikan cakalang yang terkontaminasi dengan Salmonella sp yang ditandai dengan uji Triple Suger Iron positif.
Kesimpulan : Ditemukan kontaminasi Salmonella sp. pada daging ikan cakalang yang dijual di Pasar Ikan Kedonganan dengan prevalensi cemaran sebesar 30%.
Localized multisystem inflammatory syndrome in children (mis-c), faster recovery outcome: a case report
Authors: Wintari Putu Nandika , Wati Ketut Dewi Kumara , Utama I Made Gede Dwi Lingga Utama 
Published: September 2024

Backgrounds: MIS-C cases emerged approximately 4–5 weeks on average after the peak prevalence of COVID-19. The symptoms could be asymptomatic or mildly symptomatic with fever and cough. It was unknown if these infants’ exhibited symptoms of Kawasaki disease (KD) or toxic shock syndrome (TSS), or whether they represented a condition associated with the continuing COVID-19 epidemic.
Objective: To describe clinical outcome and examination results of localized multisystem inflammatory syndrome in children.
Case presentation: A 23-month-old boy was brought to the pediatric allergy immunology clinic as a referral from a pediatrician with complaints of lump on right preauricular region, which was redden and painful, feels warm, and difficulty opening mouth. There were also multiple small nodules in peri anal area. There was fever for 1 week before admitted, accompanied by a runny nose with clear secretions with no cough. Fever already resolved at presentation. Tonsils are enlarged to T3/T4 without hyperemic nor injection. The presence of fever, conjunctivitis and cracked lips mimicking Kawasaki disease, but electrocardiography and echocardiography were normal. The MISC panel was shown support for MISC, wherein CBC showed presence of lymphopenia, anemia, neutrophilia, and thrombocytosis. Other panel MISC like the erythrocytes sedimentation rate, quantitative CRP, D-dimer, and quantitative IgG SARS-COV-2 antibodies it was reported to be increased. The patient was treated with intravenous high doses methylprednisolone pulse 10 mg/kg, then tapered off before stopped. The lump was disappeared after the second dose of HDMP, and patient was discharged after 7 days of admission.
Conclusion: We reported a localized Multisystem Inflammatory Syndrome (MIS-C) treated with high dose methylprednisolone resulting in fast recovery.
Isu strategis dalam kewirausahaan rumah sakit: Sebuah studi literatur
Authors: Ardinata Bhatara , Hardinata Felicia , Agustiany Indri , Simarmata Moida Elisabeth , Suryadi Nur Fatimah Haq , Hermansyah Taufan , Purwadhi  , Veranita Mira 
Published: September 2024

Background: A hospital is a health service institution that provides comprehensive health services for individuals by providing inpatient, outpatient, and emergency services. The strategic plan by hospital management to improve health services for the community can be determined one way: through the hospital's customer satisfaction level. Apart from carrying out humanitarian missions and quality health services, hospitals also carry out business strategies to ensure the sustainability of their management and gain profits. This research aims to determine strategic issues in hospital entrepreneurship.
Method: This research uses a literature review method. The data used in this research is secondary data, where data sources were searched using databases via Academia, Google Scholar, and Research Gate, and researchers determined 10 previous research journals that were most relevant to this research topic. Researchers use data analysis techniques: data collection, data reduction, data presentation, and drawing conclusions.
Result: The research results show that strategic issues in hospital entrepreneurship must be to increase effective promotional strategies, improve the marketing mix in hospitals, enhance the quality of service, and increase patient visits to inpatient units.
Conclusion: Implementing a hospital entrepreneurship strategy is necessary to ensure excellent and effective hospital management continuity.

Pendahuluan: Rencana strategis yang dilakukan manajemen rumah sakit untuk meningkatkan pelayanan kesehatan bagi masyarakat dapat ditentukan salah satunya melalui tingkat kepuasan pelanggan rumah sakit itu sendiri. Selain mengemban misi kemanusian dan pelayanan kesehatan yang bermutu, rumah sakit juga menjalankan strategi bisnis untuk memastikan keberlanjutan manajemennya dan mendapatkan keuntungan.Penelitian ini bertujuan untuk mengetahui isu strategis dalam kewirausahaan rumah sakit. Penelitian ini menggunakan metode literature review.
Metode: Data yang di gunakan dalam penelitian ini adalah data sekunder, dimana pencarian sumber data dilakukan menggunakan database melalui academia, google scholar, dan research gate dan peneliti menentukan 10 jurnal penelitian terdahulu yang paling relevan dengan topik penelitian ini. Teknik analisis data yang peneliti gunakan yaitu pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan.
Hasil: Isu strategis dalam kewirausahaan rumah sakit harus meningkatkan strategi promosi yang efektif, meningkatkan bauran pemasaran pada rumah sakit, meningkatkan kualitas pelayanan, dan meningkatkan kunjungan pasien unit rawat inap
Simpulan: Penerapan strategi kewirausahaan rumah sakit sangat diperlukan untuk menjamin keberlangsungan pengelolaan rumah sakit yang baik dan tepat guna.
A case report of endophthalmitis caused by Streptococcus pneumoniae serotype 3
Authors: Pramadewi Ni Made Dian , Kintami  , Tarini Ni Made Adi , Rustawan I Nengah Tony , Juliari I Gusti Ayu Made 
Published: September 2024

Background: Streptococcus pneumoniae is often the cause of infections, including eye infections such as endophthalmitis, keratitis, and conjunctivitis. Endophthalmitis is a severe infection and can cause blindness. This case report aims to investigate and report the incidence of endophthalmitis caused by S. pneumoniae.
Case presentation: We report the case of a 67-year-old man with blurred vision in his right eye accompanied by red, watery eyes, discharge, swollen eyelids. The patient was assessed as having exogenous endophthalmitis ocular dextra et causa bacterial infection with a post-secondary implant for three years. From the result of the culture and sensitivity test of the cornea and vitreous sample, S. pneumoniae was found to have a 97% probability using VITEK 2 Compact. We continued to examine the serotype using Polymerase Chain Reaction (PCR), and the result was S. pneumoniae serotype 3. The patient was treated with ceftriaxone as definitive therapy, and the condition improved.
Conclusion: S. pneumoniae is the known organism that causes one eye infection with risk factors such as previous cataract surgery. Prompt diagnosis and treatment are needed for good outcomes.
Perbandingan kemoterapi dan kombinasi imuno-kemoterapi sebagai terapi neoajuvan pada tatalaksana kasus Non Small Cell Lung Cancer (NSCLC): sebuah tinjauan pustaka
Authors: Karyadi I Gede Riswandinatha , Putra I Gusti Ngurah Agung Jaya Semara 
Published: September 2024

NSCLC is a type of lung cancer with a poor prognosis and high mortality. Providing immunotherapy as neoadjuvant therapy in addition to chemotherapy in NSCLC cases has shown benefits in improving patient prognosis. This literature review will discuss further the comparison of chemotherapy and combination immuno-chemotherapy as neoadjuvant therapy in the management of NSCLC cases.
Immunotherapy using immune checkpoint inhibitors (ICI) increases antitumor immunity by inhibiting signaling at checkpoint receptors expressed by T lymphocytes and ligands on tumor cells, which has revolutionized the therapy of several cancers, including NSCLC. Neoadjuvant therapy in the form of a combination of immuno-chemotherapy has superior clinical benefits compared to the use of chemotherapy alone as neoadjuvant therapy as evidenced by better overall survival (OS) and event-free survival (EFS), pathological remission in the form of better MPR and CPR, and higher resection rates without increasing the presence of treatment-related adverse events and post-surgical complications.
Combination immunochemotherapy is superior to chemotherapy alone as neoadjuvant therapy in treating NSCLC.

NSCLC merupakan jenis kanker paru dengan prognosis yang cenderung buruk dan mortalitas tinggi. Pemberian imunoterapi sebagai terapi neoadjuvan selain kemoterapi pada kasus NSCLC menunjukkan manfaat membaiknya prognosis pasien. Tinjauan pustaka ini akan membahas lebih lanjut mengenai perbandingan kemoterapi dan kombinasi imuno-kemoterapi sebagai terapi neoadjuvan pada tatalaksana kasus NSCLC.
Imunoterapi dengan menggunakan inhibitor cekpoint imun atau immune checkpoint inhibitors (ICI) bekerja dengan meningkatkan imunitas antitumor melalui penghambatan pensinyalan pada reseptor cekpoint yang diekspresikan oleh limfosit T dan ligan pada sel tumor telah merevolusi terapi sejumlah kanker, termasuk NSCLC. Terapi neoadjuvan berupa kombinasi imuno-kemoterapi memiliki manfaat klinis yang lebih superior dibandingkan penggunaan kemoterapi tunggal sebagai terapi neoadjuvan dibuktikan dengan angka kesintasan keseluruhan (OS) dan event free survival (EFS) yang lebih baik, remisi patologis berupa MPR dan CPR yang lebih baik, dan tingkat reseksi yang lebih tinggi tanpa meningkatkan adanya efek samping yang berkaitan dengan terapi (treatment related adverse event) dan komplikasi pasca pembedahan.
Kombinasi imunokemoterapi lebih superior dibandingkan kemoterapi tunggal sebagai terapi neoadjuvan dalam tatalaksana NSCLC.
Real-time control action formation for predicting post-accident electrical modes considering permissible stability margins
Authors: Tokhtibakiev Karmel , Gunin Alexandr , Kenessov Yerlan , Vassilyev Daniil , Bektimirov Anur 
Published: September 2024

The object of the research is an emergency control system for ensuring the stability of electric power systems (EPS) in case of emergency unbalances. The relevance of the problem of ensuring EPS stability is due to the need to improve the efficiency of emergency control to reduce the risk of system accidents with significant damage. To solve this problem, we propose an algorithm for selecting the volume of control actions based on the principles of adaptive control for predicting the post-emergency mode with an acceptable stability margin. The algorithm of forming the volume of control actions is based on the dependence of the value of control actions on the value of stability reserves estimation by the value of the Jacobi determinant. To build this dependence, the algorithm of searching for the limiting mode by the trajectory of change in the equilibrium position of the steady state of the system from the initial to the limiting one is used. In contrast to the existing algorithms, the proposed algorithm establishes a functional dependence of the control value on the current parameters of the regime or the stability margin, which increases the efficiency of calculations for selecting control actions. Realization of the proposed algorithm is carried out on the basis of the functional scheme according to the data of the vector measurement system.
The advantage and novelty of the proposed algorithm is the possibility of eliminating the disadvantages of existing systems of mode automation, the main of which are:
– the necessity to perform numerous variant calculations for selecting the volume of control actions;
– possible excessive volume of control actions in case of a mismatch of the actual mode with the calculated one
Identification of the oxidation and hydrolysis products content influence on the rapeseed oil oxidation induction period
Authors: Stankevych Serhii , Gorbunov Kostiantyn , Zabrodina Inna , Popov Mykola , Kalyna Viktoriia , Novozhylova Tetiana , Falalieieva Tetiana , Ovsiannikova Tetiana , Ponomarova Maryna , Zolotarov Andrii 
Published: September 2024

The object of the study is the dependence of the induction period of rapeseed oil on the content of oxidation and hydrolysis products. A feature of the work is determining the approximation dependence of the induction period of accelerated oxidation of refined rapeseed oil on the content of primary oxidation products and free fatty acids. This is useful when predicting the shelf life of refined rapeseed oil. It was determined that both factors negatively affect the oxidation stability of refined rapeseed oil. An increase in the peroxide value decreases the induction period of model oil samples by 32.8512 units for each additional mmol ½ O/kg. In turn, increasing the acid value of oil samples reduces the induction period by 19.8424 units for each additional mg KOH/g. Different oxidation dynamics of model samples of refined rapeseed oil with tocopherol were revealed, depending on the concentration of primary oxidation and hydrolysis products. The obtained data are explained by the fact that the primary lipid oxidation products are unstable and quickly decompose to form free radicals. These radicals initiate further lipid oxidation, resulting in reduced oil quality. In addition, free fatty acids are more reactive than triglycerides and are more easily oxidized. A feature of the obtained results is the possibility of modeling processes that affect the oxidation stability of refined rapeseed oil. From a practical point of view, the research results allow initiating measures to maintain the safety of oil-containing food products based on refined rapeseed oil. An applied aspect of using the scientific results is the possibility of rationalizing the storage conditions of refined rapeseed oil to maximize its shelf life and increase competitiveness
Designing a toolset for assessing and implementing the potential of energy-saving economic development of enterprises
Authors: Lesinskyi Valentyn , Yemelyanov Olexandr , Zarytska Oksana , Petrushka Tetyana , Myroshchenko Nataliia 
Published: September 2024

The object of this study is the evaluation and implementation of the potential of energy-saving economic development of enterprises. The task to design an effective toolkit for evaluating and implementing the specified potential was resolved.
The theoretical principles of formation and measurement of the level of energy-saving economic development of enterprises have been substantiated. A procedure for assessing the potential of energy-saving economic development of companies has been devised. This procedure involves determining the possibilities of enterprises to ensure simultaneous growth of economic results and the level of energy efficiency through the development and implementation of an optimal program of measures for such growth. The mechanism for implementing the potential of energy-saving economic development of enterprises on the basis of identifying and overcoming the main obstacles that appear on the way to such development has been improved.
The proposed theoretical and methodological approaches to the assessment and implementation of the potential of energy-saving natural gas economic development of enterprises was verified on a sample of 110 enterprises in the western region of Ukraine. In particular, it was established that the estimated potential of energy-saving natural gas economic development of the studied enterprises is very high. In particular, for more than 50 % of enterprises in all three industries, the value of this potential exceeds 6 %. At the same time, enterprises with a higher level of energy-saving economic development in the reporting period were characterized by a smaller value of this potential at the end of that period.
The toolkit proposed in this study could be used by enterprises of all types of economic activity when assessing the potential of their energy-saving economic development and when devising measures to implement the specified potential. This would help improve the economic efficiency of companies