bluuebunny/crossref_metadata_2025_split huggingface dataset:
One intervention, several benefits: Deliberate computer‐assisted argument mapping practices in an online teacher education course
Authors: Kaya Suat 
Published: September 2024

AbstractBackgroundAmbiguity prevails concerning the fundamental methodological characteristics of computer‐assisted argument mapping (CAAM) learning environments, particularly in their capacity to facilitate critical thinking within tertiary education. Previous scholarly investigations have failed to furnish an exhaustive elucidation of the configuration of instructional interventions grounded in CAAM. Furthermore, prior research provides limited evidence to show how a course can be designed and implemented with CAAM practices.ObjectivesThis study aimed to explore the influence of CAAM practices on the pre‐service teachers' critical thinking skills and the lived experiences of pre‐service teachers during CAAM practices based on their perspectives to guide more successful curriculum or instructional designs integrated with CAAM practices.MethodsThe intervention was conducted in an online course called ‘Instructional Methods and Techniques’, which included various instructional methods and techniques to be utilized while implementing a curriculum. This study employed a sequential explanatory mixed method research design conducted with 24 s grade pre‐service teachers enrolled in the elementary school department. The quantitative data gathered through a critical thinking scoring rubric were analysed with repeated measures ANOVA to analyse the change in participants' critical thinking scores over time, while a semi‐structured interview form developed by the researcher was used to collect data regarding pre‐service teachers' experiences, which were analysed with content analysis.ResultsThe quantitative findings provided empirical support for the integration of CAAM practices into teacher education programs as a means to enhance the CT skills of pre‐service teachers, while content analysis resulted in five themes named as ‘challenges, opportunities, views about Mindmup, feedback and suggestions’. The challenges encountered and subsequently overcome, the opportunities harnessed for critical thinking growth, the role of feedback in the learning process, elimination of interaction problems encountered during online learning, and the need for balanced CAAM usage all contributed to a comprehensive understanding of the potential benefits and considerations associated with CAAM in the context of teacher education.ConclusionsThese insights are invaluable for teacher educators and curriculum designers seeking to prepare future educators as effective critical thinkers capable of addressing the complex challenges within the field of education. Ultimately, the study reinforces the importance of explicit CT instruction and highlights CAAM as a promising avenue for achieving this goal.
Luteolin exerts anti‐tumour immunity in hepatocellular carcinoma by accelerating CD8+ T lymphocyte infiltration
Authors: Cai Shijiao , Gou Yidan , Chen Yanyan , Hou Xiaoran , Zhang Jing , Bi Chongwen , Gu Peng , Yang Miao , Zhang Hanxu , Zhong Weilong , Yuan Hengjie 
Published: September 2024

AbstractLuteolin, a commonly used traditional Chinese medicine, has been utilized for several decades in the treatment of hepatocellular carcinoma (HCC). Previous research has demonstrated its anti‐tumour efficacy, but its underlying mechanism remains unclear. This study aimed to assess the therapeutic effects of luteolin in H22 tumour‐bearing mice. luteolin effectively inhibited the growth of solid tumours in a well‐established mouse model of HCC. High‐throughput sequencing revealed that luteolin treatment could enhance T‐cell activation, cell chemotaxis and cytokine production. In addition, luteolin helped sustain a high ratio of CD8+ T lymphocytes in the spleen, peripheral blood and tumour tissues. The effects of luteolin on the phenotypic and functional changes in tumour‐infiltrating CD8+ T lymphocytes were also investigated. Luteolin restored the cytotoxicity of tumour‐infiltrating CD8+ T lymphocytes in H22 tumour‐bearing mice. The CD8+ T lymphocytes exhibited intensified phenotype activation and increased production of granzyme B, IFN‐γ and TNF‐α in serum. The combined administration of luteolin and the PD‐1 inhibitor enhanced the anti‐tumour effects in H22 tumour‐bearing mice. Luteolin could exert an anti‐tumour immune response by inducing CD8+ T lymphocyte infiltration and enhance the anti‐tumour effects of the PD‐1 inhibitor on H22 tumour‐bearing mice.
Unlocking reproducible transcriptomic signatures for acute myeloid leukaemia: Integration, classification and drug repurposing
Authors: Chen Haoran , Lu Jinqi , Wang Zining , Wu Shengnan , Zhang Shengxiao , Geng Jie , Hou Chuandong , He Peifeng , Lu Xuechun 
Published: September 2024

AbstractAcute myeloid leukaemia (AML) is a highly heterogeneous disease, which lead to various findings in transcriptomic research. This study addresses these challenges by integrating 34 datasets, including 26 control groups, 6 prognostic datasets and 2 single‐cell RNA sequencing (scRNA‐seq) datasets to identify 10,000 AML‐related genes (ARGs). We focused on genes with low variability and high consistency and successfully discovered 191 AML signatures (ASs). Leveraging machine learning techniques, specifically the XGBoost model and our custom framework, we classified AML subtypes with both scRNA‐seq and bulk RNA‐seq data, complementing the ELN2022 classification approach. Our research also identified promising treatments for AML through drug repurposing, with solasonine showing potential efficacy for high‐risk AML patients, supported by molecular docking and transcriptomic analyses. To enhance reproducibility and customizability, we developed CSAMLdb, a user‐friendly database platform. It facilitates the reuse and personalized analysis of nearly all results obtained in this research, including single‐gene prognostics, multi‐gene scoring, enrichment analysis, machine learning risk assessment, drug repositioning analysis and literature abstract named entity recognition. CSAMLdb is available at http://www.csamldb.com.
The Dermatology Life Quality Index (DLQI) used as the benchmark in validation of 101 quality‐of‐life instruments: A systematic review
Authors: Vyas J. , Johns J. R. , Abdelrazik Y. , Ali F. M. , Ingram J. R. , Salek S. , Finlay A. Y. 
Published: September 2024

AbstractBackgroundThe validation of psychometric measures requires use of other established and standardized validated measures. The Dermatology Life Quality Index (DLQI) is the most widely used tool to measure the burden of skin diseases and assess effectiveness of interventions based on patients' perspective.ObjectivesThe objective of this study was to systematically analyse peer‐reviewed publications describing use of the DLQI in validation of other patient‐reported outcome (PRO) and quality‐of‐life (QoL) measures.MethodsSeven databases were searched for papers published between January 1994 and December 2022 for articles containing data using DLQI in the validation of other PRO/QoL measures. The methodology followed PRISMA guidelines. The protocol was prospectively registered on PROSPERO.ResultsOf 1717 screened publications, 122 articles including 30,727 patients from 34 different countries with 41 diseases met the inclusion criteria. The DLQI was used in validation of 101 measures: 80 dermatology‐specific QoL measures, mostly disease‐specific, and 21 generic measures. Of these studies, 47 were cross‐cultural adaptations, 116 single arm, 100 were cross‐sectional, 18 longitudinal and six randomized placebo controlled. DLQI was used for 14 known group, and correlation for 10 construct, 101 convergent, 10 concurrent, 10 divergent/discriminant and three criterion validity tests using Mann–Whitney (2), Spearman's (80), Pearson's correlation (26) and Student's t‐test (1). The DLQI was used in responsiveness analysis in 13 studies.ConclusionsThis review identified widespread use of the DLQI in validation of other dermatology PRO/QoL measures and confirmed the central role that the DLQI plays as a benchmark in instrument development and validation across dermatology and beyond. The use of the DLQI by so many developers of other instruments has provided a common standard for comparability.
Interannual and seasonal migratory patterns of wheat aphids across the Bohai Strait in eastern Asia
Authors: Wang Xingya , Ma Haotian , Gao Ying , Yu Mingli , Zhao Yuechao , Wu Kongming 
Published: September 2024

AbstractThe bird cherry‐oat aphid (Rhopalosiphum padi) and the grain aphid (Sitobion miscanthi) are two destructive wheat pests that have caused severe economic losses in China's main wheat‐producing regions. Although previous studies have focused mainly on the population dynamics of wheat pests in wheat fields, little is known about the trans‐sea migration of both wheat aphid species in eastern China. Here, we conducted 10 years of monitoring from 2012 to 2021 to determine aerial migration patterns utilizing a suction trap on Beihuang Island (BH), a small island in the centre of the Bohai Strait that serves as a seasonal insect migratory pathway in eastern Asia. We also simulated the migration trajectories of these pests using the HYSPLIT model. Overall, a total of 6362 alatae S. miscanthi and 335 alatae R. padi were captured, and both wheat aphid species exhibited regular patterns of comigration across the sea from late April to late October each year. There were significant interannual and seasonal differences in the migratory numbers of both wheat aphids. Notably, the average daily humidity was the most important meteorological factor affecting migration biomass. The seasonal migration trajectories simulated using the HYSPLIT model revealed different source areas for both wheat aphid species, which mostly originated in Northeast, North and East China. Accordingly, our study provides valuable insights into the occurrence and migration route of wheat aphids in eastern Asia, helps fine‐tune forecasting and early warning systems, and thereby guides integrated pest management of wheat aphids in eastern Asia.
Effect of hearing intervention on communicative function: A secondary analysis of the ACHIEVE randomized controlled trial
Authors: Sanchez Victoria A. , Arnold Michelle L. , Garcia Morales Emmanuel E. , Reed Nicholas S. , Faucette Sarah , Burgard Sheila , Calloway Haley N. , Coresh Josef , Deal Jennifer A. , Goman Adele M. , Gravens‐Mueller Lisa , Hayden Kathleen M. , Huang Alison R. , Mitchell Christine M. , Mosley Thomas H. , Pankow James S. , Pike James R. , Schrack Jennifer A. , Sherry Laura , Weycker Jacqueline M. , Lin Frank R. , Chisolm Theresa H. ,   For the ACHIEVE Collaborative Study
Published: September 2024

AbstractBackgroundThe Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Study was designed to determine the effects of a best‐practice hearing intervention on cognitive decline among community‐dwelling older adults. Here, we conducted a secondary analysis of the ACHIEVE Study to investigate the effect of hearing intervention on self‐reported communicative function.MethodsThe ACHIEVE Study is a parallel‐group, unmasked, randomized controlled trial of adults aged 70–84 years with untreated mild‐to‐moderate hearing loss and without substantial cognitive impairment. Participants were randomly assigned (1:1) to a hearing intervention (audiological counseling and provision of hearing aids) or a control intervention of health education (individual sessions with a health educator covering topics on chronic disease prevention) and followed semiannually for 3 years. Self‐reported communicative function was measured with the Hearing Handicap Inventory—Elderly Screening version (HHIE‐S, range 0–40, higher scores indicate greater impairment). Effect of hearing intervention versus control on HHIE‐S was analyzed through an intention‐to‐treat model controlling for known covariates.ResultsHHIE‐S improved after 6‐months with hearing intervention compared to control, and continued to be better through 3‐year follow‐up. We estimated a difference of −8.9 (95% CI: −10.4, −7.5) points between intervention and control groups in change in HHIE‐S score from baseline to 6 months, −9.3 (95% CI: −10.8, −7.9) to Year 1, −8.4 (95% CI: −9.8, −6.9) to Year 2, and − 9.5 (95% CI: −11.0, −8.0) to Year 3. Other prespecified sensitivity analyses that varied analytical parameters did not change the observed results.ConclusionsHearing intervention improved self‐reported communicative function compared to a control intervention within 6 months and with effects sustained through 3 years. These findings suggest that clinical recommendations for older adults with hearing loss should encourage hearing intervention that could benefit communicative function and potentially have positive downstream effects on other aspects of health.
Outcome‐Based Typology of Social Enterprises: Interlacing Individual Transformation, Capital Provision, and Societal Influence
Authors: Polychronopoulos Georgios , Lukeš Martin , Sansone Giuliano , Agrawal Anirudh , Ulrich‐Diener Florian , Šlapáková Losová Veronika 
Published: September 2024

AbstractSocial entrepreneurship has emerged as a global phenomenon aimed at tackling societal grand challenges through market‐based activities. A holistic understanding of social enterprise outcomes is crucial for reflecting their effectiveness in meeting social objectives and informing internal organizational processes. This study explores the outcomes of social enterprises through a comparative qualitative analysis of 49 social ventures in Austria, Canada, Czechia, Denmark, Germany, Greece, India, Italy, the Netherlands, and the United States, spanning diverse sectors. Three key outcome dimensions are identified: individual transformation, capital provision, and societal influence. Our analysis results in a typology of seven distinct types of social enterprises, each integrating these dimensions to varying degrees. Utilizing this typology, we reveal how social enterprises navigate barriers to solving complex social and environmental problems, illustrating the dynamic interplay between outcome dimensions and the importance of multi‐objective organizing – beyond hybrid organizing – in addressing complex societal issues.
Presenteeism pressure: The development of a scale and a nomological network
Authors: Smith Claire E. , McAbee Samuel T. , Freier Lindsey , Huang Susannah , Albert Melissa A. 
Published: September 2024

AbstractThe social context of the workplace influences attendance decisions. Regardless of personal and job factors, employees may choose to engage in sickness presenteeism behaviour (i.e., working when unwell) because of perceived pressure from the organization. Using Social Information Processing Theory, we introduce the construct of presenteeism pressure to capture this perception that an organization normalizes and expects employees to engage in presenteeism. Through a scale development study of working adults (N = 219), we create and refine the 11‐item Presenteeism Pressure Scale. Next, we provide evidence of convergent and discriminant validity of the scale in an independent sample of working adults (N = 248). We then concurrently examine presenteeism pressure's place in a nomological network of constructs within the presenteeism and broader organizational literature, in another sample (N = 764). Finally, we increase the rigour of our validation efforts by conducting an additional two‐wave study (N = 350) and expanding the nomological network of presenteeism pressure to include relevant work outcomes. Our results position presenteeism pressure as a unique and promising contributor to the understanding of presenteeism behaviours and work behaviours more generally. We conclude with suggestions for integrating presenteeism pressure into existing theory and better‐informed organizational attendance procedures.
Pathogenicity and Virulence‐Associated Factors of Pseudomonas syringae pv. syringae and [P. amygdali pv. morsprunorum] Strains From New Zealand Sweet Cherry (Prunus avium) Orchards
Authors: Marroni M. Virginia , Casonato Seona , Visnovsky Sandra B. , Pitman Andrew R. , Beresford Robert M. , Jones E. Eirian 
Published: September 2024

ABSTRACTPreviously genetically characterised strains of Pseudomonas syringae. pv. syringae (Pss), [P. amygdali pv. morsprunorum] (Pam, syn. P. s. pv. morsprunorum race 1) and Pseudomonas spp. from New Zealand were characterised for their pathogenicity and aggressiveness in plant tissue and associated virulence factors. Lesions on detached, Pss‐inoculated immature fruit increased rapidly in size and, at 10 days post inoculation (dpi), had larger areas under the disease progress curve (AUDPC) than Pam‐inoculated fruit (48.9 and 22.0, respectively). Detached leaves infiltrated with Pss‐developed symptoms within 1 dpi and from 2 dpi for Pam. Necrosis from most Pss strains extended into the leaf veins by 7 dpi, while Pam strains' necrosis was confined to the inoculation site. On detached 1‐year‐old cherry shoots, Pseudomonas spp. strains exhibited the smallest mean lesion size (2.1–2.4 mm), whereas larger mean lesion sizes were observed with Pss strains (5.7–13.7 mm) and Pam strains (3.9–14.0 mm). A functional T3SS was inferred for Pss and Pam strains based on the hypersensitivity reactions observed on tobacco leaves and symptoms elicited on cherry tissue. Syringomycin production was prevalent (88%) among Pss strains. In contrast, only 1.4% of Pam strains produced coronatine. Most Pss strains (97.0%) were able to catalyse ice formation. The coexistence of strains with varying degrees of virulence and non‐pathogenic strains suggests a complex ecological balance, where multiple factors, including genetic variation, virulence traits and environmental conditions, shape the population dynamics and disease outcomes.
Grow with the flow: Is phenotypic plasticity across hydrodynamic gradients common in seaweeds?
Authors: Coleman Liam J. M. , Martone Patrick T. 
Published: September 2024

AbstractSeaweeds are widely assumed to be phenotypically plastic across hydrodynamic gradients, yet while many marine macroalgae exhibit intraspecific phenotypic variation that correlates with flow, researchers often fail to test whether such variation is due to plasticity or another mechanism, such as local adaptation. In this minireview, we considered mechanisms for sensing flow in seaweeds that could facilitate adaptive phenotypic plasticity across hydrodynamic gradients. We then reviewed the literature from 1900 to 2024 to see how often phenotypic variation and plasticity across hydrodynamic gradients had been observed and demonstrated in different groups of seaweeds. In the last 124 years, phenotypic variation and plasticity in response to flow have been well documented in brown algae but scarcely documented in red and green algae. This could suggest that brown algae are better able to sense and respond to flow than red and green algae, perhaps due to the intercalary meristem of many brown algae, including most kelps. However, this skewed distribution could also be the result of publication bias, as most studies involving flow have been conducted on brown algae. Only 30% of 141 papers specifically investigated if observations of phenotypic variation along hydrodynamic gradients were due to plasticity. To date, phenotypic plasticity in response to flow has been demonstrated in 20 brown algal species, five red algal species, and two green algal species. Thus, the assumption that phenotypic plasticity to flow is common across seaweeds is not particularly well supported by the literature. Mechanisms underlying plasticity to flow are poorly understood and remain a critical avenue for future research.
Lexical Effects on Second Language Grammar Acquisition: Testing Psycholinguistic and Neurocognitive Predictions
Authors: Hopp Holger , Reifegerste Jana , Ullman Michael T. 
Published: September 2024

AbstractSecond language (L2) grammar learning is difficult. Two frameworks—the psycholinguistic lexical bottleneck hypothesis and the neurocognitive declarative/procedural model—predict that faster L2 lexical processing should facilitate L2 incidental grammar learning. We tested these predictions in a pretest–posttest syntactic adaptation study of English relative‐clause attachment preferences. First‐language German speakers listened to relative clauses disambiguated to the English low‐attachment preference (secretaries of the professor who is/naps at home)—via either a copula (e.g., is), which should be processed rapidly (copula group; n = 48), or a lexical verb (e.g., naps), which should be processed more slowly (lexical group; n = 48). Only the copula group showed significant pretest‐to‐posttest learning. Moreover, the amount of learning was predicted by procedural learning abilities in the copula group, but by vocabulary size in the lexical group. The results, which are consistent with both frameworks, show that the L2 lexicon impacts L2 grammar learning, and reveal moderating psycholinguistic and neurocognitive variables.
Predictors of Postoperative Urinary Incontinence After Holmium Laser Enucleation of the Prostate (HoLEP) for Surgeons Early in Their Experience
Authors: Doersch Karen M. , Hines Laena , Campbell Timothy D. , Jain Rajat K. , Quarrier Scott O. 
Published: September 2024

ABSTRACTObjectivesTo evaluate factors impacting continence recovery following holmium laser enucleation of the prostate (HoLEP) for surgeons early in their HoLEP experience.MethodsPredefined factors were evaluated from a prospectively maintained database for their impact on the recovery of continence after HoLEP. Both surgeons had performed fewer than 150 HoLEPs as attending physicians. Inclusion criteria were subjects with at least 6 months of incontinence data or documented recovery of continence. One or fewer pads per day was defined as continence. Statistical analyses were performed using R and Prism and included Spearman correlations, linear modeling, and Mantel–Cox log‐rank testing as appropriate.ResultsFrom December 2020 to May 2023, 152 subjects met inclusion criteria with a median age of 70 (range: 51–93). The median case number was 56 (1–146). Within the study period, 144/152 (94.7%) recovered continence at a median of 1.6 months postoperatively. Linear modeling demonstrated that younger age (p = 0.01) and shorter enucleation time (p = 0.001) predicted recovery. Enucleation time less than 100 min predicted earlier continence recovery based on Mantel–Cox testing (p = 0.0004).ConclusionsDuring the surgeons' HoLEP learning curve, age, and enucleation time were predictive of the recovery of continence. Enucleation time under 100 min predicted a faster rate of continence recovery. The relationship between enucleation time and continence recovery may be demonstrative of case difficulty or may be a result of pressure on the external urethral sphincter during enucleation. These findings further our understanding of HoLEP outcomes early in a surgeon's learning curve.