bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability, Validity, and Clinical Utility of the Dominic Interactive for Adolescents–Revised
Authors: Bergeron Lise , Smolla Nicole , Berthiaume Claude , Renaud Johanne , Breton Jean-Jacques , St.-Georges Marie , Morin Pauline , Zavaglia Elissa , Labelle Réal 
Published: September 2016

Objectives: The Dominic Interactive for Adolescents–Revised (DIA-R) is a multimedia self-report screen for 9 mental disorders, borderline personality traits, and suicidality defined by the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-5). This study aimed to examine the reliability and the validity of this instrument. Methods: French- and English-speaking adolescents aged 12 to 15 years ( N = 447) were recruited from schools and clinical settings in Montreal and were evaluated twice. The internal consistency was estimated by Cronbach alpha coefficients and the test-retest reliability by intraclass correlation coefficients. Cutoff points on the DIA-R scales were determined by using clinically relevant measures for defining external validation criteria: the Schedule for Affective Disorders and Schizophrenia for School-Aged Children, the Beck Hopelessness Scale, and the Abbreviated-Diagnostic Interview for Borderlines. Receiver operating characteristic (ROC) analyses provided accuracy estimates (area under the ROC curve, sensitivity, specificity, likelihood ratio) to evaluate the ability of the DIA-R scales to predict external criteria. Results: For most of the DIA-R scales, reliability coefficients were excellent or moderate. High or moderate accuracy estimates from ROC analyses demonstrated the ability of the DIA-R thresholds to predict psychopathological conditions. These thresholds were generally capable to discriminate between clinical and school subsamples. However, the validity of the obsessions/compulsions scale was too low. Conclusions: Findings clearly support the reliability and the validity of the DIA-R. This instrument may be useful to assess a wide range of adolescents’ mental health problems in the continuum of services. This conclusion applies to all scales, except the obsessions/compulsions one.
« We make markets ». Le rôle du salon Ethical Fashion Show dans la catégorisation de la mode éthique
Authors: Blanchet Vivien 
Published: September 2016

Résumé Les catégories participent à la construction des marchés en définissant les producteurs, les consommateurs et les produits substituables. Jusqu’à présent, la littérature sur le sujet s’est concentrée sur les effets des catégories au détriment de leur émergence. Cette recherche comble cette limite en étudiant le rôle du salon Ethical Fashion Show dans la formation de la catégorie mode éthique. Sur la base d’une analyse qualitative d’entretiens, de données secondaires, d’observations et d’objets, elle analyse les pratiques visant à formaliser le projet critique de la mode éthique, à définir ses principes et à diffuser la catégorie. L’article offre quatre contributions. Il révèle le rôle de la critique dans l’émergence des catégories. Il montre que leur contenu est façonné par des pratiques de purification et d’hybridation. Il éclaire le rôle des porte-paroles dans la diffusion des catégories. Enfin, en s’inspirant de la théorie de l’acteur-réseau, il théorise la catégorisation comme un processus de traduction.
Assessment of bone healing ability of calcium phosphate cements loaded with platelet lysate in rat calvarial defects
Authors: Babo Pedro S , Carvalho Pedro P , Santo Vítor E , Faria Susana , Gomes Manuela E , Reis Rui L 
Published: September 2016

Injectable calcium phosphate cements have been used as a valid alternative to autologous bone grafts for bone augmentation with the additional advantage of enabling minimally invasive implantation procedures and for perfectly fitting the tissue defect. Nevertheless, they have low biodegradability and lack adequate biochemical signaling to promote bone healing and remodeling. In previous in vitro studies, we observed that the incorporation of platelet lysate directly into the cement paste or loaded in hyaluronic acid microspheres allowed to modulate the cement degradation and the in vitro expression of osteogenic markers in seeded human adipose derived stem cells. The present study aimed at investigating the possible effect of this system in new bone formation when implanted in calvarial bilateral defects in rats. Different formulations were assessed, namely plain calcium phosphate cements, calcium phosphate cements loaded with human platelet lysate, hybrid injectable formulations composed of the calcium phosphate cement incorporating hyaluronin acid non-loaded microparticles (20% hyaluronin acid) or with particles loaded with platelet lysate. The degradability and new bone regrowth were evaluated in terms of mineral volume in the defect, measured by micro-computed tomography and histomorphometric analysis upon 4, 8 and 12 weeks of implantation. We observed that the incorporation of hyaluronin acid microspheres induced an overly rapid cement degradation, impairing the osteoconductive properties of the cement composites. Moreover, the incorporation of platelet lysate induced higher bone healing than the materials without platelet lysate, up to four weeks after surgery. Nevertheless, this effect was not found to be significant when compared to the one observed in the sham-treated group.
Neighborhood Context and Youth Physical Activity: Differential Associations by Gender and Age
Authors: Kowaleski-Jones Lori , Fan Jessie X. , Wen Ming , Hanson Heidi 
Published: September 2016

Purpose: The goal of this research is to examine the extent to which facets of neighborhood sociodemographic contexts influence individual-level physical activity (PA) among youth. Design: Using National Health and Nutrition Examination Survey (NHANES), geographic information systems (GIS), and census data sources, we explicitly test whether built environment factors have differential associations depending on the age and gender of the youth living in urban census tracts. Setting: Participants are from the NHANES 2003 to 2006 waves. Participants: The study sample for this article was 2706 youth aged 6 to 17 years with valid PA accelerometer measures. Measures: A measure of park accessibility was constructed from the 2006 park GIS layer in Environmental System Research Institute ArcGIS 9.3 data. Average daily minutes of moderate to vigorous PA in bouts equal to or longer than 1 minute were recorded using accelerometers over 4 to 7 days. Analysis: Analysis was conducted with SAS 9.2, including descriptive analyses and linear regression for PA. Results: Findings suggest that built environment features are especially salient for adolescents and youth living in urban areas. Vigorous activity varied by the age and gender of the youth. For example, greater distance to parks is associated with a decrease in PA among girls and boys aged 6 to 11 years. Among teens, distance to parks is significantly associated with decreases in PA among the total sample and among male teens. However, an increase in population density is associated with less time spent in PA among youth aged 6 to 11 years but more PA among teens. Conclusion: These analyses represent an important step to considering the implications of modifiable environmental features for youth and contrast with existing literature for adults. Results speak to the efficacy of built environment measures in urban communities and the importance of considering the possibility of differing patterns of associations in childhood and adolescence and by gender. Results from this research inform policy efforts to interdict in the growing trend of youth inactivity in the United States.
Challenges in implementing an advance care planning programme in long-term care
Authors: McGlade Ciara , Daly Edel , McCarthy Joan , Cornally Nicola , Weathers Elizabeth , O’Caoimh Rónán , Molloy D William 
Published: September 2016

Background: A high prevalence of cognitive impairment and frailty complicates the feasibility of advance care planning in the long-term-care population. Research aim: To identify challenges in implementing the ‘Let Me Decide’ advance care planning programme in long-term-care. Research design: This feasibility study had two phases: (1) staff education on advance care planning and (2) structured advance care planning by staff with residents and families. Participants and research context: long-term-care residents in two nursing homes and one community hospital. Ethical considerations: The local research ethics committee granted ethical approval. Findings: Following implementation, over 50% of all residents had completed some form of end-of-life care plan. Of the 70 residents who died in the post-implementation period, 14% had no care plan, 10% (with capacity) completed an advance care directive and lacking such capacity, 76% had an end-of-life care plan completed for them by the medical team, following discussions with the resident (if able) and family. The considerable logistical challenge of releasing staff for training triggered development of an e-learning programme to facilitate training. Discussion: The challenges encountered were largely concerned with preserving resident’s autonomy, avoiding harm and suboptimal or crisis decision-making, and ensuring residents were treated fairly through optimisation of finite resources. Conclusions: Although it may be too late for many long-term-care residents to complete their own advance care directive, the ‘ Let Me Decide’ programme includes a feasible and acceptable option for structured end-of-life care planning for residents with variable capacity to complete an advance care directive, involving discussion with the resident (to the extent they were able) and their family. While end-of-life care planning was time-consuming to deliver, nursing staff were willing to overcome this and take ownership of the programme, once the benefits in improved communication and enhanced peace of mind among all parties involved became apparent in practice.
The Khorana Score in Predicting Venous Thromboembolism for Patients With Metastatic Urothelial Carcinoma and Variant Histology Treated With Chemotherapy
Authors: Ramos Jorge D. , Casey Martin F. , Bamias Aristotelis , De Giorgi Ugo , Bellmunt Joaquim , Harshman Lauren C. , Ladoire Sylvain , Wong Yu-Ning , Alva Ajjai S. , Rosenberg Jonathan E. , Galsky Matthew D. , Yu Evan Y. ,   Retrospective International Study of Cancers of the Urothelium (RISC) Investigators
Published: September 2016

Background: The Khorana score is a predictive risk model for venous thromboembolism (VTE) in patients with cancer planning to receive chemotherapy. Urothelial carcinoma and variant histologies (UC/VH) were underrepresented in the model. We sought to evaluate whether the Khorana score predicts for VTE in a retrospective multinational data set of patients with metastatic UC/VH. Methods: Patients diagnosed with metastatic UC/VH who received chemotherapy were eligible. Those with incomplete or miscoded data were excluded. Khorana scores were calculated based on the pretreatment data and categorized into high (≥3) or intermediate (1-2) VTE risk. Other patient-, tumor-, and therapy-related factors were also analyzed. The χ2 and logistic regression analyses were used to assess differences in VTE rates based on the clinical characteristics. Subgroup analyses were performed to evaluate the Khorana score and associated variables for early (<3 months) and late (>3 months) VTE. Results: A total of 943 patients were eligible for analysis. The cumulative VTE rate was 9.9%. There was no statistical difference in overall VTE rate between Khorana high- and intermediate-risk groups ( P = .16). In the multivariate analysis, nonurothelial histology (odds ratio [OR] = 2.56; P = .002) and the presence of cardiovascular disease (CVD) or CVD risk factors (OR = 2.14; P = .002) were associated with increased VTE risk. In the first 3 months from initiation of chemotherapy, Khorana high risk (OR = 2.08; P = .04) was associated with higher VTE rates. White blood cell (WBC) count (OR = 1.05; P = .04) was the only significant Khorana variable for early VTE. Conclusions: The Khorana score stratifies early but not overall VTE risk in patients with metastatic UC/VH. The WBC count drives the increased early VTE risk seen with the Khorana score.
Concomitant Use of Proton-Pump Inhibitors and Clopidogrel Increases the Risk of Adverse Outcomes in Patients With Ischemic Stroke Carrying Reduced-Function CYP2C19*2
Authors: Yi Xingyang , Han Zhao , Zhou Qiang , Cheng Wen , Lin Jing , Wang Chun 
Published: September 2016

Objective: Conflicting data exist as to whether proton-pump inhibitors (PPIs) diminish the efficacy of clopidogrel. The aim of this study was to investigate the association between cytochrome P450 ( CYP) genetic variants and clinical adverse outcomes of concomitant use of PPIs and clopidogrel by patients. Methods: We consecutively enrolled 523 patients with ischemic stroke receiving clopidogrel. Platelet aggregation was measured before and after 7 to 10 days of clopidogrel treatment. Single-nucleotide polymorphisms of CYP3A4, CYP3A5, CYP2C19*2, and CYP2C19*3 were examined using mass spectrometry. The primary outcome was a composite of recurrent ischemic stroke (RIS), myocardial infarction (MI), and vascular death that occurred during the 1-year follow-up period. The safety outcome was hemorrhagic episodes that occurred during the 1-year follow-up period. Results: This study comprised a total of 523 patients with IS, 96.3% (155/161) patients treated with PPIs and 95.9% (347/362) in patients treated without PPIs completed 1-year follow-up. The primary outcome was observed in 69 (13.7%) patients (56 RIS, 7 MI, and 6 died). There was no significant difference in the frequencies of primary outcome and safety outcome between patients treated with or without PPIs. The frequency of primary outcome was significantly higher in patients carrying CYP2C19*2 AG/AA genotype receiving PPIs compared with the same genotype in those not receiving PPIs. The PPIs used in patients carrying CYP2C19*2 AG/AA was independently associated with the primary outcome after adjusting for other risk factors. Conclusions: The concomitant use of PPIs and clopidogrel may be associated with an increased risk of RIS, MI, or vascular death in patients with IS carrying reduced-function CYP2C19*2.
The association of ACE gene polymorphism with diabetic kidney disease and renoprotective efficacy of valsartan
Authors: Wang Yuying , Peng Wen , Zhang Xiaoxue , Qiao Huibo , Wang Li , Xu Zhigang , Wu Chenguang 
Published: September 2016

Introduction: To investigate the associations between the insertion/deletion (I/D) polymorphisms in the angiotensin converting enzyme ( ACE) gene and susceptibility to diabetic kidney disease (DKD); and the efficacy of valsartan in reducing the urine protein in Type 2 diabetes mellitus (T2DM) patients. Materials and methods: We enrolled 128 T2DM patients in this study, including 54 cases with DKD (DKD+) and 74 controls (DKD–). The ACE polymorphism was assayed by polymerase chain reaction (PCR), and the genotype distribution and allele frequency were analyzed. The DKD+ group was subdivided into the DD, ID and II subgroups, based on their genotypes. In addition, patients with DKD received valsartan treatment for 12 weeks. We determined changes in the urinary albumin to creatinine ratio (ACR) and serum creatinine (SCr). Results: The frequencies of the genotypes DD and ID were higher in the DKD+ than in the DKD– group. The frequency of allele D was higher, and of allele I was lower, in the DKD+ than in DKD– group ( p < 0.05). Following valsartan treatment, albuminuria was significantly decreased in subgroups DD and ID ( p < 0.05). Conclusions: In T2DM patients, the ACE I/D polymorphism was associated with onset of DKD. Furthermore, the ACE I/D polymorphism influenced the renoprotective response to valsartan: Patients with the DD genotype benefitted the most from this treatment.
Structural alignment of protein descriptors – a combinatorial model
Authors: Antczak Maciej , Kasprzak Marta , Lukasiak Piotr , Blazewicz Jacek 
Published: September 2016

Abstract
Background
Structural alignment of proteins is one of the most challenging problems in molecular biology. The tertiary structure of a protein strictly correlates with its function and computationally predicted structures are nowadays a main premise for understanding the latter. However, computationally derived 3D models often exhibit deviations from the native structure. A way to confirm a model is a comparison with other structures. The structural alignment of a pair of proteins can be defined with the use of a concept of protein descriptors. The protein descriptors are local substructures of protein molecules, which allow us to divide the original problem into a set of subproblems and, consequently, to propose a more efficient algorithmic solution. In the literature, one can find many applications of the descriptors concept that prove its usefulness for insight into protein 3D structures, but the proposed approaches are presented rather from the biological perspective than from the computational or algorithmic point of view. Efficient algorithms for identification and structural comparison of descriptors can become crucial components of methods for structural quality assessment as well as tertiary structure prediction.

Results
In this paper, we propose a new combinatorial model and new polynomial-time algorithms for the structural alignment of descriptors. The model is based on the maximum-size assignment problem, which we define here and prove that it can be solved in polynomial time. We demonstrate suitability of this approach by comparison with an exact backtracking algorithm. Besides a simplification coming from the combinatorial modeling, both on the conceptual and complexity level, we gain with this approach high quality of obtained results, in terms of 3D alignment accuracy and processing efficiency.

Conclusions
All the proposed algorithms were developed and integrated in a computationally efficient tool descs-standalone, which allows the user to identify and structurally compare descriptors of biological molecules, such as proteins and RNAs. Both PDB (Protein Data Bank) and mmCIF (macromolecular Crystallographic Information File) formats are supported. The proposed tool is available as an open source project stored on GitHub (

).
Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers
Authors: Faden Daniel L. , Arron Sarah T. , Heaton Chase M. , DeRisi Joseph , South Andrew P. , Wang Steven J. 
Published: September 2016

Background Little is known regarding the etiology and genomic underpinnings of Oral Tongue Squamous Cell Carcinoma (OTSCC) in patients who lack traditional risk factors, yet the incidence is increasing. In particular, the rate, and role, of TP53 mutations in this cohort has been heavily debated in the literature. Methods Tumor DNA from forty-three non-smokers with OTSCC underwent next generation sequencing of TP53. Results Sixty percent of samples contained a TP53 mutation. The G > T transversion rate was 5.7 %. TP53 status did not differ by age. Conclusions OTSCC in non-smokers have TP53 mutation rates similar to other Head and Neck cancers yet these mutations do not appear related to carcinogen exposure based on the mutational spectrum and clinical history. The mechanisms driving tumorigenesis in this cohort, including mutations in TP53, remain elusive and further studies are needed.
Love and Theft: Plagiarism, Blackface, and Nella Larsen’s “Sanctuary”
Authors: Hochman Barbara 
Published: September 2016

Abstract
When Nella Larsen’s story “Sanctuary” appeared in the Forum in 1930, readers noted its similarity to “Mrs. Adis,” a tale by the popular British writer Sheila Kaye-Smith. Scholars concur that “Sanctuary” turns a story about British class-consciousness into a story of African American race loyalty. This essay suggests that the intertextuality of Larsen’s “Sanctuary” extends beyond “Mrs. Adis” to a neglected 1903 novella by Edith Wharton, also titled Sanctuary, and that in writing her last story Larsen “blackens up”—imitating, mocking, and distortedly mirroring both sources. Larsen’s “Sanctuary” bitterly critiques the triumph of culture, education, and moral agency in Wharton’s tale, while reworking “Mrs. Adis” to expose group solidarity as a poor substitute for autonomy, segregation in another guise. Larsen’s “Sanctuary” reveals the false promises held out to African Americans by a series of values that were much recommended to them: literacy, filial devotion, Christian charity, and group allegiance.
Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity
Authors: Annesley Sarah J. , Lay Sui T. , De Piazza Shawn W. , Sanislav Oana , Hammersley Eleanor , Allan Claire Y. , Francione Lisa M. , Bui Minh Q. , Chen Zhi-Ping , Ngoei Kevin R. W. , Tassone Flora , Kemp Bruce E. , Storey Elsdon , Evans Andrew , Loesch Danuta Z. , Fisher Paul R. 
Published: September 2016

ABSTRACT
In combination with studies of post-mortem Parkinson's disease (PD) brains, pharmacological and genetic models of PD have suggested that two fundamental interacting cellular processes are impaired – proteostasis and mitochondrial respiration. We have re-examined the role of mitochondrial dysfunction in lymphoblasts isolated from individuals with idiopathic PD and an age-matched control group. As previously reported for various PD cell types, the production of reactive oxygen species (ROS) by PD lymphoblasts was significantly elevated. However, this was not due to an impairment of mitochondrial respiration, as is often assumed. Instead, basal mitochondrial respiration and ATP synthesis are dramatically elevated in PD lymphoblasts. The mitochondrial mass, genome copy number and membrane potential were unaltered, but the expression of indicative respiratory complex proteins was also elevated. This explains the increased oxygen consumption rates by each of the respiratory complexes in experimentally uncoupled mitochondria of iPD cells. However, it was not attributable to increased activity of the stress- and energy-sensing protein kinase AMPK, a regulator of mitochondrial biogenesis and activity. The respiratory differences between iPD and control cells were sufficiently dramatic as to provide a potentially sensitive and reliable biomarker of the disease state, unaffected by disease duration (time since diagnosis) or clinical severity. Lymphoblasts from control and PD individuals thus occupy two distinct, quasi-stable steady states; a ‘normal’ and a ‘hyperactive’ state characterized by two different metabolic rates. The apparent stability of the ‘hyperactive’ state in patient-derived lymphoblasts in the face of patient ageing, ongoing disease and mounting disease severity suggests an early, permanent switch to an alternative metabolic steady state. With its associated, elevated ROS production, the ‘hyperactive’ state might not cause pathology to cells that are rapidly turned over, but brain cells might accumulate long-term damage leading ultimately to neurodegeneration and the loss of mitochondrial function observed post-mortem. Whether the ‘hyperactive’ state in lymphoblasts is a biomarker specifically of PD or more generally of neurodegenerative disease remains to be determined.