bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Factors Associated with Clinical Response in Melanoma Patients Treated with Talimogene Laherparapvec: A Single-Institution Retrospective Analysis
Authors: Sierra-Davidson Kailan , Dedeilia Aikaterini , Lawless Aleigha , Sharova Tanya , Kaufman Howard L. , Boland Genevieve M. , Cohen Sonia 
Published: October 2024

Abstract
Background
Talimogene laherparapvec (T-VEC) is a modified herpes simplex virus type 1 (HSV-1) and the first oncolytic virus to be approved for the treatment of unresectable melanoma. We assessed whether there are tumor-intrinsic genetic factors that are associated with tumor control.

Methods
A single-institution, retrospective analysis of melanoma patients treated with T-VEC was performed. Demographics, histopathologic reports, treatment history, clinical outcomes, and tumor genomic analysis of approximately 100 genes were collected.

Results
Ninety-three patients who had received T-VEC were identified, of whom 84 (91%) were diagnosed with cutaneous melanoma. Sixty-nine (69) patients received more than one dose of T-VEC and had sufficient data available for clinical analysis. Of these patients 30.0% (n = 21) had evidence of a complete response, defined as complete regression of all lesions without the need for additional treatment or procedures. Stage III disease (p < 0.001), absence of macroscopic nodal disease (p < 0.001), and absence of visceral/central nervous system metastases (p = 0.004) were all associated with evidence of any clinical response or local control by univariate analysis. At the time of analysis, 54 patients had tumor genetic data available. Sixty genes were mutated in at least one patient, and all but one patient had at least one gene mutation identified. Presence of TERT promotor mutation was associated with evidence of any clinical response (p = 0.043) or local control (p = 0.039) by multivariate analysis.

Conclusions
This work describes the experience using T-VEC in melanoma at a single institution and highlights the presence of TERT promotor mutations as a possible driver of clinical response.
The Effect of Health Literacy Level and Some Growth Parameters on Quality of Life of Celiac Adolescents
Authors: Bakirlioğlu Burcu , Çetinkaya Bengü 
Published: October 2024

Background: Celiac is an autoimmune disease that occurs as hypersensitivity to gluten and affects the intestinal system. This disease also negatively affects the quality of life of individuals. This study, it was aimed to investigate the effect of health literacy level and Body Mass Index (BMI) on the quality of life of adolescents with celiac disease.
Method and Material: All participants between the ages of 15-18 in the study completed the Turkish Health Literacy Scale (THLS-32) and Celiac Disease-Specific Pediatric Quality of Life (CDPQOL) Scale online. The data of this study was analyzed with the IBM SPSS Statistics 23 software package program.
Results: More than half (59%) of adolescents with an average age of 16.44 ±1.17 years had celiac disease for 3 years or more. CDPQOL mean total score was 41.44±14.33, and 44.4% of the participants had inadequate or problematic levels of health literacy. It was determined that the mean of total score of quality of life was not related to THLS-32 sub-dimensions but had a moderate negative relationship with diagnostic time and BMI (r=-0.376, p=0.005; r=-0.602, p=0.00, respectively). At the same time, it was found that the decrease in BMI was a predictive factor for poor quality of life (B=-0.218, p=0.003).
Conclusions: It has been shown that the health literacy levels of celiac adolescents are not related to the quality of life, and it is recommended to examine the quality of life with other variables that can be affected by many factors.
Interventions to reduce opioid use for patients with chronic non-cancer pain in primary care settings: A systematic review and meta-analysis
Authors: Cai Qian , Grigoroglou Christos , Allen Thomas , Chen Teng-Chou , Chen Li-Chia , Kontopantelis Evangelos 
Published: October 2024

Objective
This systematic review and meta-analysis aimed to assess interventions to reduce opioid use for patients with chronic non-cancer pain (CNCP) versus usual care or active controls in primary care settings.

Methods
In this registered study (PROSPERO: CRD42022338458), we searched MEDLINE, Embase PsycInfo, CINAHL, and Cochrane Library from inception to December 28th 2021, and updated on Dec 14th 2023 for randomized controlled trials (RCTs) and cohort studies with no restrictions. Methodological quality was assessed using the Cochrane Risk of Bias tool for RCTs and Newcastle Ottawa Scale for cohort studies. Primary outcomes included mean reduction in morphine equivalent daily dose (reported as mean differences [MDs] mg/day; 95% confidence intervals [95%CIs]) and/or opioid cessation proportion. Secondary outcomes were mean changes in pain severity (reported as standardized mean difference [SMDs]; 95%CIs) and (serious) adverse events. Meta-analyses were performed using random-effects models.

Results
We identified 3,826 records, of which five RCTs (953 participants) and five cohort studies (901 participants) were included. Overall, opioid dosage was significantly reduced in intervention groups compared to controls (MD: -28.63 mg/day, 95%CI: -39.77 to -17.49; I2 = 31.25%; eight studies). Subgroup analyses revealed significant opioid dose reductions with mindfulness (MD: -29.36 mg/day 95%CI: -40.55 to -18.17; I2 = 0.00%; two trials) and CBT-based multimodalities (MD: -41.68 mg/day; 95%CI: -58.47 to -24.89; I2 = 0.00%; two cohort studies), respectively, compared to usual care. No significant differences were observed in opioid cessation (Odds ratio: 1.10, 95%CI: -0.48 to 2.67, I2 = 58.59%; two trials) or pain severity (SMD: -0.13, 95%CI: -0.37 to 0.11; I2 = 33.51%; three trials). Adverse events were infrequently examined, with withdrawal symptoms commonly reported.

Conclusions
The studied interventions were effective in reducing opioid dosage for people with CNCP in primary care. They highlighted the importance of multidisciplinary collaboration. Large-scale RCTs measuring the long-term effects and cost of these interventions are needed before their implementation.
Optimising co-design processes in telemedicine innovation–developing a telemedical solution for emergency medical services
Authors: Klager Elisabeth , Lintschinger Josef Michael , Teufel Anna , Schaden Eva , Manschein Valerie , Reischmann-Senoner Lena , Ulbing Stefan , Willschke Harald , Frimmel Christoph , Renner Reinhold , Grill Christiane , Hafner Christina 
Published: October 2024

Background
Stakeholder engagement plays a vital role in driving advancements in product development. This imperative now extends to the healthcare domain, driven by the scarcity of healthcare professionals and the pressing demand for effective solutions. Through the application of design thinking and co-design methodologies, this study endeavours to promote comprehensive stakeholder involvement, creating streamlined processes and adaptable templates geared towards fostering innovative solutions for tele-emergency medicine.

Methods
In this study design thinking and co-design methods are developed, adapted, and tested, to create effective tools and demonstrate their application. This is part of a process involving stakeholders and lead users to develop a telemedicine solution for emergency medical services. This research is descriptive in kind, offering a transparent and holistic portrayal of the co-design process. The rural region of Burgenland in Austria was chosen for this study, with the challenges of its weak infrastructure offering valuable insights. The tools were tested in co-design workshops, with the participants continuously observed by the research team.

Results
Seventeen healthcare professionals, emergency medical technicians and academics participated in a co-design process to develop a telemedicine solution for emergency medical services. The results section presents practical co-creative healthcare innovation tools and templates that have been shown to facilitate the co-design process.

Conclusions
The study developed and applied co-design elements for the creation of a prototype concept for telemedicine in emergency medicine and offers valuable insights for similar projects involving diverse stakeholders. It shows that structured co-design activities help all stakeholders to jointly create solutions that meet the overall needs.
The EuroFlow PIDOT external quality assurance scheme: enhancing laboratory performance evaluation in immunophenotyping of rare lymphoid immunodeficiencies
Authors: Neirinck Jana , Buysse Malicorne , Brdickova Naděžda , Perez-Andres Martín , De Vriendt Ciel , Kerre Tessa , Haerynck Filomeen , Bossuyt Xavier , van Dongen Jacques J.M. , Orfao Alberto , Hofmans Mattias , Bonroy Carolien , Kalina Tomas 
Published: October 2024

Abstract

Objectives
The development of External Quality Assessment Schemes (EQAS) for clinical flow cytometry (FCM) is challenging in the context of rare (immunological) diseases. Here, we introduce a novel EQAS monitoring the primary immunodeficiency Orientation Tube (PIDOT), developed by EuroFlow, in both a ‘wet’ and ‘dry’ format. This EQAS provides feedback on the quality of individual laboratories (i.e., accuracy, reproducibility and result interpretation), while eliminating the need for sample distribution.

Methods
In the wet format, marker staining intensities (MedFIs) within landmark cell populations in PIDOT analysis performed on locally collected healthy control (HC) samples, were compared to EQAS targets. In the dry format, participants analyzed centrally distributed PIDOT flow cytometry data (n=10).

Results
We report the results of six EQAS rounds across 20 laboratories in 11 countries. The wet format (212 HC samples) demonstrated consistent technical performance among laboratories (median %rCV on MedFIs=34.5 %; average failure rate 17.3 %) and showed improvement upon repeated participation. The dry format demonstrated effective proficiency of participants in cell count enumeration (range %rCVs 3.1–7.1 % for the major lymphoid subsets), and in identifying lymphoid abnormalities (79.3 % alignment with reference).

Conclusions
The PIDOT-EQAS allows laboratories, adhering to the standardized EuroFlow approach, to monitor interlaboratory variations without the need for sample distribution, and provides them educational support to recognize rare clinically relevant immunophenotypic patterns of primary immunodeficiencies (PID). This EQAS contributes to quality improvement of PID diagnostics and can serve as an example for future flow cytometry EQAS in the context of rare diseases.
State-of-art review of beyond design basis evaluation approach of a generic nuclear power plant in the UK
Authors: Filipov Svetlin , Tan Ming , Ford Peter , Zhuo Xunjia 
Published: October 2024

Abstract
The Fukushima accident prompted rapid development in the appreciation and codification of BDB methodology into regulatory guidance and this is still continuing, especially at IAEA, which has recently and is due to publish several new standards documents directly relevant to BDB analysis. The objective of this paper is to provide a state-of-art review on how BDB evaluations are undertaken in the UK nuclear industry. Then, using the work undertaken for the Generic Design Assessment (GDA) in the UK for UK HPR1000, this paper proposed a more systematic approach for “cliff-edge” evaluation based on a generic nuclear power plant design currently being developed in the UK.
Spiritual dryness and its predictors in Iranian Muslims
Authors: Ashrafizadeh Hadis , Farahani Azam Shirinabadi , Büssing Arndt , Rassouli Maryam 
Published: October 2024

Abstract
Illness, disability, and life-threatening events rank among the most significant crises that give rise to spiritual challenges. These challenges can lead to a dichotomy of spiritual dryness and cohesion, a phenomenon that can manifest in any demographic group due to illness or other crises. Within the Iranian Muslim community, various groups – healthy and sick, religious and non-religious – have consistently experienced spiritual dryness. This observation aligns with findings from other studies, particularly those involving Christians. However, the factors predicting spiritual dryness in these individuals have differed from those in other populations. Given that spirituality often serves as a potent strategy for navigating life’s crises, it is crucial to provide holistic support and spiritual care to those grappling with this phenomenon. This approach can help mitigate negative outcomes and foster positive ones, such as post-traumatic growth.
Temperature dependence of irradiation-induced amorphization in a high-entropy titanate pyrochlore
Authors: Weber William J. , Kinsler-Fedon Candice , Keppens Veerle , Zhang Yanwen , Mir Anamul H. 
Published: October 2024

AbstractThe temperature dependence of amorphization in a high-entropy pyrochlore, (Yb0.2Tm0.2Lu0.2Ho0.2Er0.2)2Ti2O7, under irradiation with 600 keV Xe ions has been studied using in situ transmission electron microscopy (TEM). The critical amorphization dose increases with temperature, and the critical temperature for amorphization is 800 K. At room temperature, the critical amorphization dose is larger than that previously determined for this pyrochlore under bulk-like 4 MeV Au ion irradiation but is similar to the critical doses determined in two other high-entropy titanate pyrochlores under 800 keV Kr ion irradiation using in situ TEM, which is consistent with reported behavior in simple rare-earth titanate pyrochlores.
Graphical abstract
Survival after targeted chemotherapy and unresectable biliary malignancies (systematic review and meta-analysis)
Authors: Tseimakh A. E. , Mitshhenko A. N. , Shoikhet Ya. N. 
Published: October 2024

Aim. To evaluate the survival rate of patients with unresectable biliary malignancies under targeted chemotherapy in order to identify the most promising adjuvant regimens.Materials and methods. The study involves publications in PubMed Central, RSCI, and Cochrane databases. Heterogeneity was assessed graphically (blobograms) and statistically (τ 2 and I2 ).Results. Meta-analysis of five-year survival revealed a greater pooled estimate of the period in the main groups treated with targeted chemotherapy – 295 ± 71 days (95% CI 144–408; p <0.001) against comparison groups – 205 ± 81 days (95% CI 81–426; p <0.001). Study heterogeneity was considered moderate (I2 = 0%, p = 0.06). No significant publication errors and biases were revealed in both meta-analyses.Conclusion. Targeted chemotherapy increases the overall survival of patients with unresectable malignancies of the bile ducts. Systemic chemotherapy based on gemcitabine and cisplatin with addition of ivosidenib, a selective inhibitor of mutant IDH1, showed the best efficacy.
Morphological rationale for surgical treatment of patients with true splenic artery aneurysm
Authors: Shabunin A. V. , Bagateliya Z. A. , Bedin V. V. , Tavobilov M. M. , Karpov A. A. , Alieva F. F. , Gordienko E. N. 
Published: October 2024

Aim. To study the morphological features of the wall structure of the splenic artery aneurysm in order to identify the safest and most effective method of surgical treatment.Materials and methods. From 2020 to 2023, 43 patients underwent surgery for true splenic artery aneurysm. Interventions involved laparoscopic clipping of aneurysm branches, laparoscopic resection of aneurysm, laparoscopic splenectomy, and resection of giant splenic artery aneurysm. A clinical and morphological study of 16 slides of splenic artery aneurysm was performed. The aneurysm wall and the adjacent wall of the splenic artery without macroscopic signs of lumen dilatation for 1 cm from the aneurysmal dilatation were examined.Results. Microscopic study revealed fragments of loose, edematous wall of large elastic arteries with atherosclerosis, atheromatosis and calcification. Atherosclerotic plaques were observed in the intima; calcium deposits were detected in 81.25% of slides, and defects in elastic fibers – in all slides. The elastic membrane was thinned or had a discontinuous structure. Morphological changes in the wall of the splenic artery persisted up to 1.0 ± 0.2 cm proximal and distal to the aneurysm.Conclusion. Taking into account the revealed features of the morphological structure of the aneurysm, the formation of an end-to-end vascular anastomosis of the splenic artery, clipping or suturing of the aneurysm neck pose a significant risk of aneurysm recurrence. Laparoscopic clipping of splenic artery aneurysm branches at a distance of >1.5 cm from the edges of the aneurysm becomes the operation of choice for patients in this category.
Specifics and results of liver transplantation in elderly patients
Authors: Voskanyan S. E. , Sushkov A. I. , Rudakov V. S. , Kolyshev I. Yu. , Popov M. V. , Naydenov E. V. , Svetlakova D. S. , Lukyanchikova A. S. , Pashkov A. N. , Muktarzhan M. , Kalachyan A. E. , Syutkin V. E. , Artemiev A. I. 
Published: October 2024

Aim. To determine specific features, frequency, and structure of complications, immediate and long-term results of liver transplantation in elderly patients.Materials and methods. Data on 529 liver transplantations performed consecutively in one medical center from 2010 to 2023 were analyzed. In 386 (73%) cases, the right lobe of the liver of related donors was used for transplantation. At the time of surgery, the patient age ranged from 18 years to 71 years, with 57 (11%) patients being over 60 years old, 215 (40%) patients aged 44–59 years, and 257 (49%) patients aged 18–44 years.Results. Prior to operation, elderly patients were statistically significantly more often diagnosed with arterial hypertension (n = 19; 33%), diabetes mellitus (n = 12; 21%), and on average a reduced glomerular filtration rate (82 ml/min/1.73m2 ). The most frequent indication for transplantation in this group was hepatocellular carcinoma in the setting of cirrhosis (n = 19; 33%). No statistically significant differences in other preoperative characteristics, parameters of donors and operations, peculiarities of the course of the early postoperative period, frequency, structure of complications and lethal outcomes were found. The one-, five-, and ten-year survival rates for recipients over 60 years old were 82%, 72%, and 36%; for recipients aged 44–59 years old – 88%, 79%, and 70%; and for recipients aged 18–44 years old – 86%, 80%, and 74%, respectively.Conclusion. In the studied cohort, older age was not associated with excessive risks of complications and early postoperative mortality. Given the higher prevalence of comorbidities in this group, preoperative examination should be aimed at, among other things, diagnostics of possible (hidden) cardiovascular and oncologic diseases. The development and introduction of new cardio-, nephro-, and oncoprotective regimens of immunosuppressive therapy seems to be an important measure not only for the surgical treatment of elderly patients, but also for recipients living with a transplanted liver for a long time.
Application of indocyanine green during laparoscopic cholecystectomy in elderly and senile patients
Authors: Kabanov M. Yu. , Glushkov N. I. , Sementsov K. V. , Boyarinov D. Yu. , Fomenko E. E. , Myanzelin M. N. 
Published: October 2024

Aim. To evaluate an effect of fluorescence cholangiography for intraoperative identification of extrahepatic bile ducts on the treatment outcomes of patients with cholelithiasis.Materials and methods. The study included 71 cholelithiasis patients who underwent laparoscopic cholecystectomy with fluorescence cholangiography and 69 cholelithiasis patients who underwent standard laparoscopic cholecystectomy. The study analyzed intraoperative damage of extrahepatic bile ducts and arteries, duration of surgery, conversion rate, need for colleague assistance, incidence of postoperative complications, hospital length of stay, and outcomes.Results. Fluorescence of the vesicular duct was achieved in 100% of patients, of the common bile duct – in 91%, and of the common hepatic duct – in 64%. A correlation between the number/type of complications and the application of ICG-diagnostics was found statistically significant (p <0.001, p = 0.012), thereby indicating the advantages of the method. The colleague-surgeon assistance was required in the ICG group 35 times less than in the standard surgery group (OR = 0.029; 95% CI = 0.003–0.319). A 34-minute reduction in surgery duration (linear regression) can be expected when performing ICG-guided surgery.Conclusion. The application of fluorescence cholangiography reduces the probability of postoperative complications, in particular, biliary leakage with the necessity of reoperation. Due to the method, a surgeon appears able to complete the operation independently without colleague assistance. Treatment outcomes, incidence of bile duct injuries, and conversion rate are yet to be investigated.
KİŞİLİK ÖZELLİKLERİYLE TOPLUMSAL CİNSİYET ALGI DÜZEYLERİ ARASINDAKİ İLİŞKİ: BELEDİYE ÇALIŞANLARI ÖRNEĞİ
Authors: Yıldız Fatma Zehra , Atalay Emine , Gündoğmuş Emine , Yener Aydın Bırsen 
Published: October 2024

Bu çalışmanın amacı, belediye çalışanlarının kişilik özelliklerinin toplumsal cinsiyet algı düzeylerinin ilişkisinin incelenmesidir. Yine çalışanların beş faktör kişilik özelliklerinin ve toplumsal cinsiyet algılarına ilişkin; cinsiyet, yaş grupları, medeni hâl, eğitim, çalışılan yıl, çalışma şekli, gelir durumu, gelirin yeterlilik durumuna göre farklılık durumlarının ortaya konması çalışma kapsamında ele alınan amaçlardandır. Bu araştırmada nicel araştırma yöntemi kullanılmıştır. Araştırmanın çalışma evrenini bir belediyedeki 5000 beyaz yakalı çalışan oluşturmaktadır. Araştırma kapsamında, kolayda örnekleme yolu kullanılmış ve bu kapsamda farklı demografik özelliklere sahip bireylere ulaşılmaya çalışılmıştır. Araştırma kapsamında veri toplama aracı olarak anket yönteminden faydalanılmıştır. Araştırma sonrasında toplanan tüm veriler, “IBM SPSS Statistics” 25.0 paket programıyla tahlil edilmiştir.	Beş faktör kişilik özellikleri ile toplumsal cinsiyet algı düzeyleri arasında anlamlı bir ilişki olduğu ve bu ilişkinin pozitif yönlü zayıf bir ilişki olduğu görülmüştür. Belediye çalışanlarının kişilik özellikleriyle toplumsal cinsiyet algı düzeyleri çalışma şekillerine göre farklılaştığı görülmüştür. Bu çalışmada erkek belediye çalışanlarının kadın çalışanlara göre toplumsal cinsiyet algısı daha yüksek düzeyde belirlenmiştir. Bu durum, toplumsal olarak toplumsal cinsiyetle ilgili farkındalığın gelişimi olarak değerlendirilmektedir.
Prevalence of thyroid dysfunction in namakkal district -A hospital based study
Authors: Philip Sachu , Abrahim Philips 
Published: October 2024

Thyroid disorders are most common endocrine disorder in India but the prevalence studies on these dysfunction is limited. All subjects who visited the hospital for a period of four months to have thyroid function tests (TFTs) on their first outpatient visit were included in the study. Thyroid disordrs were present in 22.11 % of the total 2510 subjects . The prevalence rate was higher in females (64.8%) than males (35.2%) with (p=0.0003).The prevalence of hypothyroidism in the study population was 64.32 % (n = 357). In our study those with primary hypothyroidism were predominant (55.18 %, 197 out of 357) and 43.1 % (154 out of 357) were having sub clinical hypothyroidism and 6 of 357 were having secondary hypothyroidism. The prevalence rate of hyperthyroidism was 52.6 % (n-188) . The majority were subclinical hyperthyroidism (65.90 % , 124 out of 188) ,30.8 % (58 out of 188) had primary hyperthyroidism and3% ( 6 out of 188) had secondary hyperthyroidism. In our study thyroid function abnormalities were noted in 15.73 % of all subjects. Thyroid disorders were common in age of &#62;20 years than 20-40 ,40-60 and and &#62;60 year categories. The prevalence of primary hypothyroidism was found to be higher than subclinical hypothyroidism, while in hyperthyroidism subclinical condition was predominant compared to primary hyperthyroidism.