bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo analgesic, antipyretic and anti-inflammatory potential of leaf extracts and fractions of Eria javanica
Authors: Bhuiya N. M. Mahmudul Alam , Hasan Mahmud , Mahmud Zobaer Al , Qais Nazmul , Kabir Mohammad Shah Hafez , Ahmed Farhan , Uddin Mir Muhammad Nasir 
Published: March 2017

Abstract

Background
The objective of the study was to evaluate the antinociceptive, antipyretic and anti-inflammatory activities of ethanolic extract, methanolic extract and n-hexane and chloroform-soluble fractions of methanolic extract of Eria javanica leaves in animal model (rat and mice).

Methods
The anti-nociceptive potentials of the extracts were studied using the acetic acid-induced writhing test in mice and the antipyretic activity was investigated using yeast-induced pyrexia in rats. Anti-inflammatory activity test was done on rats at a dose by using carrageenan-induced paw edema test.

Results
In acetic acid-induced writhing inhibition study in Swiss albino mice, the crude methanolic extract at 200 mg/kg and 400 mg/kg doses and the n-hexane soluble fraction of crude methanolic extract at 400 mg/kg showed statistically significant activity with 53.21 % (p<0.001), 50.36 % (p<0.001) and 67.86 % (p<0.001) inhibition respectively compared to control. The crude ethanolic extract showed statistically significant antipyretic activity from 1 hours and onwards after administration at doses of 200 mg/kg body weight (p<0.005 at 1st hour and p<0.001 at 2nd, 3rd and 4th hour respectively) and 400 mg/kg body weight (p<0.05 at 1st hour and p<0.001 at 2nd, 3rd and 4th hour respectively). The crude methanolic extract showed statistically significant antipyretic activity from 2 hours and onwards at 400 mg/kg body weight (p<0.05 at 2nd hour and p<0.001 at 3rd and 4th hour respectively) and 200 mg/kg body weight dose showed statistically significant antipyretic activity from 3 hours and onward(p<0.001) in Brewer’s yeast-induced pyrexia test in albino Wister rats. In carrageenan-induced rat’s paw edema test, crude methanolic extract showed statistically significant anti-inflammatory activity from 2nd hour and onwards. The chloroform-soluble fraction of methanolic extract also showed significant activity from 1st hour onwards.

Conclusions
This study thereby indicates that leaves of E. javanica possess peripheral analgesic, antipyretic and anti-inflammatory activities and therefore a suitable candidate for further study.
A nonlinear plate control without linearization
Authors: Yildirim Kenan , Kucuk Ismail 
Published: March 2017

Abstract
In this paper, an optimal vibration control problem for a nonlinear plate is considered. In order to obtain the optimal control function, wellposedness and controllability of the nonlinear system is investigated. The performance index functional of the system, to be minimized by minimum level of control, is chosen as the sum of the quadratic 10 functional of the displacement. The velocity of the plate and quadratic functional of the control function is added to the performance index functional as a penalty term. By using a maximum principle, the nonlinear control problem is transformed to solving a system of partial differential equations including state and adjoint variables linked by initial-boundary-terminal conditions. Hence, it is shown that optimal control of the nonlinear systems can be obtained without linearization of the nonlinear term and optimal control function can be obtained analytically for nonlinear systems without linearization.
Bi-integrable and tri-integrable couplings of a soliton hierarchy associated with SO(4)
Authors: Zhang Jian , Zhang Chiping , Cui Yunan 
Published: March 2017

Abstract
In our paper, the theory of bi-integrable and tri-integrable couplings is generalized to the discrete case. First, based on the six-dimensional real special orthogonal Lie algebra SO(4), we construct bi-integrable and tri-integrable couplings associated with SO(4) for a hierarchy from the enlarged matrix spectral problems and the enlarged zero curvature equations. Moreover, Hamiltonian structures of the obtained bi-integrable and tri-integrable couplings are constructed by the variational identities.
Rheophilic fish in oxbow lakes of the Warta River – the effect of environmental conditions on habitat selection
Authors: Golski Janusz , Pińskwar Piotr , Jezierska-Madziar Maria , Andrzejewski Wojciech , Mazurkiewicz Jan , Stanisławski Daniel , Urbańska Maria 
Published: March 2017

Abstract
Oxbow lakes are typical elements of meandering watercourses and are considered to be key components of floodplains of natural rivers. A permanent connection with the river promotes the use of these water bodies by ichthyofauna as spawning grounds, shelter for fry, feeding and wintering grounds. The aim of this study was to determine which rheophilic species inhabit oxbow lakes and how environmental conditions affect habitat selection and fish behavior. Analyses were conducted on six oxbow lakes of the Warta River in the Koło-Poznań section. Fish and water samples were collected for three years, in spring, summer and late autumn. Variation in environmental conditions in the analyzed water bodies results in a considerable diversity of the ichthyofauna, including rheophilic species, in individual seasons of the year. In the course of the study, nine rheophilic fish species were recorded, including four from the lithophilic reproductive guild having the highest environmental requirements. Relative abundance of rheophilic species in the dominance structure ranged from 0 to 100%, depending on the reservoir and seasons, with an average of 7% for all catches. For comparison, their relative abundance in the adjacent parts of the river was 12 and 23%.
The impact of amur sleeper (Perccottus glenii Dybowsky, 1877) on the riverine ecosystem: food selectivity of amur sleeper in a recently colonized river
Authors: Rau Marius Andrei , Plavan Gabriel , Strungaru Stefan Adrian , Nicoara Mircea , Rodriguez-Lozano Pablo , Mihu-Pintilie Alin , Ureche Dorel , Klimaszyk Piotr 
Published: March 2017

Abstract
The presented study aimed at comprehensive assessment of the Perccottus glenii (Amur sleeper) impact on the aquatic ecosystem. Our objective was to analyze the diet, the characteristics of the prey and the feeding behavior of the Amur sleeper. Fish (349 individuals) were captured by electrofishing in autumn 2012. To estimate the dietary importance of each prey category, we calculated the percentage or proportion of each food item and its frequency of occurrence. The Costello graphical method was applied to describe the feeding strategy and prey importance. A total number of 55 taxa of benthic macroinvertebrates were identified, amounting to a total of 2448 individuals. The digestive tract was empty in 48 individuals of the Amur sleeper. The most frequent prey items of the Amur sleeper were Asellus aquaticus L, Baetis spp., the Chironomidae family which was represented by 22 taxa identified to the genus and species levels, Corixa spp. and Physa acuta Drap. Depending on the frequency of prey items, two categories of size classes with specific diet compositions in the Amur sleeper populations were determined. Feeding strategy, cluster indicators of the size classes and traits of macroinvertebrates were the main aspects covered by our study of the Amur sleeper feeding behavior.
Massive occurrence of the alien invasive species Pleodorina indica (Volvocales, Chlorophyta) in a reservoir located in urban areas of Central Poland
Authors: Knysak Piotr , Żelazna-Wieczorek Joanna 
Published: March 2017

Abstract

Pleodorina indica (Iyengar) H. Nozaki is a rare species from the Volvocaceae family (Chlorophyta, Volvocales), which naturally occurs in aquatic ecosystems of the tropical climate zones. This is the first record of this species I in Poland in a flow-through man-made reservoir on the Olechówka River in Łódź. The sampling site of P. indica in Łódź is the northernmost site in Europe. Among other records, the species has been also reported from Austria in 1996 and the Czech Republic in 2003. During the summer of 2015, abundant occurrence of this species was observed at the sampling site, at extremely high air and water temperatures. Physical parameters in the reservoir and the duration of the P. indica bloom were measured. In addition, morphological features of the species were observed with the use of light and confocal microscopy.
Highly conductive barium iron vanadate glass containing different metal oxides
Authors: Nishida Tetsuaki , Izutsu Yukimi , Fujimura Mina , Osouda Keito , Otsuka Yuki , Kubuki Shiro , Oka Nobuto 
Published: March 2017

Abstract
20BaO·5ZnO·5Fe2O3·70V2O5 glass annealed at 450°C for 30 min showed a marked decrease in the electric resistivity (ρ) from 4.0×105 to 4.8 Ωcm, while 20BaO·5Cu2O·5Fe2O3·70V2O5 glass from 2.0×105 to 5.0 Ωcm. As for the conduction mechanism, it proved that n-type semiconductor model in conjugation with the small polaron hopping theory was most probable. Since ZnII and CuI have a 3d10-electron configuration in the outer-most orbital, Ga2O3- and GeO2-containing vanadate glasses were explored in this study. 20BaO·5Ga2O3·5Fe2O3·70V2O5 glass showed a less remarkable decrease of ρ from 4.5×105 to 100 Ωcm, and 20BaO·5GeO2·5Fe2O3·70V2O5 glass from 3.3×106 to 400 Ωcm. Activation energies for the conduction (E
a) of GeO2- and Ga2O3-contaning glasses before the annealing were respectively estimated to be 0.42 and 0.41 eV. It proved that barium iron vanadate glass with a smaller E
a value could attain the higher conductivity after the annealing at temperaures higher than the crystalization temperature.
Sensemaking, stakeholder discord, and long-term risk communication at a US Superfund site
Authors: Hoover Anna Goodman 
Published: March 2017

AbstractIntroduction:Risk communication can help reduce exposures to environmental contaminants, mitigate negative health outcomes, and inform community-based decisions about hazardous waste sites. While communication best practices have long guided such efforts, little research has examined unintended consequences arising from such guidelines. As rhetoric informs stakeholder sensemaking, the language used in and reinforced by these guidelines can challenge relationships and exacerbate stakeholder tensions.Objectives:This study evaluates risk communication at a U.S. Superfund site to identify unintended consequences arising from current risk communication practices.Methods:This qualitative case study crystallizes data spanning 6 years from three sources: 1) local newspaper coverage of site-related topics; 2) focus-group transcripts from a multi-year project designed to support future visioning of site use; and 3) published blog entries authored by a local environmental activist. Constant comparative analysis provides the study’s analytic foundation, with qualitative data analysis software QSR NVivo 8 supporting a three-step process: 1) provisional coding to identify broad topic categories within datasets, 2) coding occurrences of sensemaking constructs and emergent intra-dataset patterns, and 3) grouping related codes across datasets to examine the relationships among them.Results:Existing risk communication practices at this Superfund site contribute to a dichotomous conceptualization of multiple and diverse stakeholders as members of one of only two categories: the government or the public. This conceptualization minimizes perceptions of capacity, encourages public commitment to stances aligned with a preferred group, and contributes to negative expectations that can become self-fulfilling prophecies.Conclusion:Findings indicate a need to re-examine and adapt risk communication guidelines to encourage more pluralistic understanding of the stakeholder landscape.
Semi-Immersive Virtual Turbine Engine Simulation System
Authors: Abidi Mustufa H. , Al-Ahmari Abdulrahman M. , Ahmad Ali , Darmoul Saber , Ameen Wadea 
Published: March 2017

AbstractThe design and verification of assembly operations is essential for planning product production operations. Recently, virtual prototyping has witnessed tremendous progress, and has reached a stage where current environments enable rich and multi-modal interaction between designers and models through stereoscopic visuals, surround sound, and haptic feedback. The benefits of building and using Virtual Reality (VR) models in assembly process verification are discussed in this paper. In this paper, we present the virtual assembly (VA) of an aircraft turbine engine. The assembly parts and sequences are explained using a virtual reality design system. The system enables stereoscopic visuals, surround sounds, and ample and intuitive interaction with developed models. A special software architecture is suggested to describe the assembly parts and assembly sequence in VR. A collision detection mechanism is employed that provides visual feedback to check the interference between components. The system is tested for virtual prototype and assembly sequencing of a turbine engine. We show that the developed system is comprehensive in terms of VR feedback mechanisms, which include visual, auditory, tactile, as well as force feedback. The system is shown to be effective and efficient for validating the design of assembly, part design, and operations planning.
Regulation of hypoxia responses by flavin adenine dinucleotide‐dependent modulation of HIF‐1α protein stability
Authors: Yang Suk‐Jin , Park Young Soo , Cho Jung Hee , Moon Byul , An Hyun‐Jung , Lee Ju Yeon , Xie Zhi , Wang Yuli , Pocalyko David , Lee Dong Chul , Sohn Hyun Ahm , Kang Minho , Kim Jin Young , Kim Eunhee , Park Kyung Chan , Kim Jung‐Ae , Yeom Young Il 
Published: March 2017

AbstractOxygen deprivation induces a range of cellular adaptive responses that enable to drive cancer progression. Here, we report that lysine‐specific demethylase 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia‐inducible factor (HIF) ubiquitination machinery, and consequently suppressing the oxygen‐independent degradation of HIF‐1α. This ability of LSD1 is attenuated during prolonged hypoxia, with a decrease in the cellular level of flavin adenine dinucleotide (FAD), a metabolic cofactor of LSD1, causing HIF‐1α downregulation in later stages of hypoxia. Exogenously provided FAD restores HIF‐1α stability, indicating a rate‐limiting role for FAD in LSD1‐mediated HIF‐1α regulation. Transcriptomic analyses of patient tissues show that the HIF‐1 signature is highly correlated with the expression of LSD1 target genes as well as the enzymes of FAD biosynthetic pathway in triple‐negative breast cancers, reflecting the significance of FAD‐dependent LSD1 activity in cancer progression. Together, our findings provide a new insight into HIF‐mediated hypoxia response regulation by coupling the FAD dependence of LSD1 activity to the regulation of HIF‐1α stability.
Genetic Dissection of a QTL Affecting Bone Geometry
Authors: Sabik Olivia L , Medrano Juan F , Farber Charles R 
Published: March 2017

Abstract
Parameters of bone geometry such as width, length, and cross-sectional area are major determinants of bone strength. Although these traits are highly heritable, few genes influencing bone geometry have been identified. Here, we dissect a major quantitative trait locus (QTL) influencing femur size. This QTL was originally identified in an F2 cross between the C57BL/6J-hg/hg (HG) and CAST/EiJ strains and was referred to as femur length in high growth mice 2 (Feml2). Feml2 was located on chromosome (Chr.) 9 at ∼20 cM. Here, we show that the HG.CAST-(D9Mit249-D9Mit133)/Ucd congenic strain captures Feml2. In an F2 congenic cross, we fine-mapped the location of Feml2 to an ∼6 Mbp region extending from 57.3 to 63.3 Mbp on Chr. 9. We have identified candidates by mining the complete genome sequence of CAST/EiJ and through allele-specific expression (ASE) analysis of growth plates in C57BL/6J × CAST/EiJ F1 hybrids. Interestingly, we also find that the refined location of Feml2 overlaps a cluster of six independent genome-wide associations for human height. This work provides the foundation for the identification of novel genes affecting bone geometry.
Genetic and Transgenic Reagents forDrosophila simulans,D. mauritiana,D. yakuba,D. santomea, andD. virilis
Authors: Stern David L , Crocker Justin , Ding Yun , Frankel Nicolas , Kappes Gretchen , Kim Elizabeth , Kuzmickas Ryan , Lemire Andrew , Mast Joshua D , Picard Serge 
Published: March 2017

AbstractSpecies of the Drosophila melanogaster species subgroup, including the species D. simulans, D. mauritiana, D. yakuba, and D. santomea, have long served as model systems for studying evolution. However, studies in these species have been limited by a paucity of genetic and transgenic reagents. Here, we describe a collection of transgenic and genetic strains generated to facilitate genetic studies within and between these species. We have generated many strains of each species containing mapped piggyBac transposons including an enhanced yellow fluorescent protein (EYFP) gene expressed in the eyes and a ϕC31 attP site-specific integration site. We have tested a subset of these lines for integration efficiency and reporter gene expression levels. We have also generated a smaller collection of other lines expressing other genetically encoded fluorescent molecules in the eyes and a number of other transgenic reagents that will be useful for functional studies in these species. In addition, we have mapped the insertion locations of 58 transposable elements in D. virilis that will be useful for genetic mapping studies.
Bacteremia in Children 3 to 36 Months Old After Introduction of Conjugated Pneumococcal Vaccines
Authors: Greenhow Tara L. , Hung Yun-Yi , Herz Arnd 
Published: March 2017

BACKGROUND AND OBJECTIVES:
In June 2010, Kaiser Permanente Northern California replaced all 7-valent pneumococcal conjugate vaccine (PCV7) vaccines with the 13-valent pneumococcal conjugate vaccine (PCV13). Our objectives were to compare the incidence of bacteremia in children 3 to 36 months old by 3 time periods: pre-PCV7, post-PCV7/pre-PCV13, and post-PCV13.

METHODS:
We designed a retrospective review of the electronic medical records of all blood cultures collected on children 3 to 36 months old at Kaiser Permanente Northern California from September 1, 1998 to August 31, 2014 in outpatient clinics, in emergency departments, and in the first 24 hours of hospitalization.

RESULTS:
During the study period, 57 733 blood cultures were collected in the population of children 3 to 36 months old. Implementation of routine immunization with the pneumococcal conjugate vaccine resulted in a 95.3% reduction of Streptococcus pneumoniae bacteremia, decreasing from 74.5 to 10 to 3.5 per 100 000 children per year by the post-PCV13 period. As pneumococcal rates decreased, Escherichia coli, Salmonella spp, and Staphylococcus aureus caused 77% of bacteremia. Seventy-six percent of all bacteremia in the post-PCV13 period occurred with a source.

CONCLUSIONS:
In the United States, routine immunizations have made bacteremia in the previously healthy toddler a rare event. As the incidence of pneumococcal bacteremia has decreased, E coli, Salmonella spp, and S aureus have increased in relative importance. New guidelines are needed to approach the previously healthy febrile toddler in the outpatient setting.
Self-Reported Mental Health Problems Among Adults Born Preterm: A Meta-analysis
Authors: Pyhälä Riikka , Wolford Elina , Kautiainen Hannu , Andersson Sture , Bartmann Peter , Baumann Nicole , Brubakk Ann-Mari , Evensen Kari Anne I. , Hovi Petteri , Kajantie Eero , Lahti Marius , Van Lieshout Ryan J. , Saigal Saroj , Schmidt Louis A. , Indredavik Marit S. , Wolke Dieter , Räikkönen Katri 
Published: March 2017

CONTEXT:
Preterm birth increases the risk for mental disorders in adulthood, yet findings on self-reported or subclinical mental health problems are mixed.

OBJECTIVE:
To study self-reported mental health problems among adults born preterm at very low birth weight (VLBW; ≤1500 g) compared with term controls in an individual participant data meta-analysis.

DATA SOURCES:
Adults Born Preterm International Collaboration.

STUDY SELECTION:
Studies that compared self-reported mental health problems using the Achenbach Young Adult Self Report or Adult Self Report between adults born preterm at VLBW (n = 747) and at term (n = 1512).

DATA EXTRACTION:
We obtained individual participant data from 6 study cohorts and compared preterm and control groups by mixed random coefficient linear and Tobit regression.

RESULTS:
Adults born preterm reported more internalizing (pooled β = .06; 95% confidence interval .01 to .11) and avoidant personality problems (.11; .05 to .17), and less externalizing (–.10; –.15 to –.06), rule breaking (–.10; –.15 to –.05), intrusive behavior (–.14; –.19 to –.09), and antisocial personality problems (–.09; –.14 to –.04) than controls. Group differences did not systematically vary by sex, intrauterine growth pattern, neurosensory impairments, or study cohort.

LIMITATIONS:
Exclusively self-reported data are not confirmed by alternative data sources.

CONCLUSIONS:
Self-reports of adults born preterm at VLBW reveal a heightened risk for internalizing problems and socially avoidant personality traits together with a lowered risk for externalizing problem types. Our findings support the view that preterm birth constitutes an early vulnerability factor with long-term consequences on the individual into adulthood.
Fortalecimiento financiero municipal a través de los hechos generadores de plusvalía
Authors: Ruiz Hernández Alejandro Alberto 
Published: March 2017

<p>La participación en las plusvalías urbanas tiene su fuente en el poder fiscal que la constitución asigna a los municipios para el establecimiento de los tributos con los que financiará el desarrollo territorial, en ejercicio de la autonomía política y fiscal. Para la participación de los municipios en las plusvalías urbanas, los hechos generadores tienen su fuente en las decisiones administrativas que configuran la acción urbanística, en este caso se investigaron en otros entes territoriales de Colombia, para analizar el deber ser teniendo en cuenta la parte jurídica, técnica, procedimental y financiera. El nacimiento de la obligación depende de las decisiones administrativas adoptadas por los municipios en el ejercicio de la función pública de urbanismo: las acciones urbanísticas contempladas por la ley como hechos generadores, la delimitación de una zona homogénea beneficiaria de plusvalía, el cálculo del efecto plusvalía y la liquidación del efecto plusvalía para cada inmueble. Las acciones urbanísticas hechos generadores de la participación de los municipios en las plusvalías urbanas deberán estar contenidas o autorizadas en los planes de ordenamiento territorial o en los instrumentos que los desarrollen o complementen, los cuales serán tenidos en cuenta, sea en conjunto o cada una por separado, para determinar el efecto de la plusvalía o los derechos adicionales de construcción y desarrollo, cuando fuere del caso.</p><div> </div>