bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversibility of chemotherapy-induced senescence is independent of autophagy and a potential model for tumor dormancy and cancer recurrence
Authors: Saleh Tareq , Cudjoe Emmanuel K. , Kyte S. Lauren , Henderson Scott C. , Elmore Lynne W. , Gewirtz David A. 
Published: January 2017

AbstractAutophagy and senescence are both well-established responses to chemotherapy and radiation that often occur in parallel, contributing to growth arrest in tumor cells. However, it has not been established whether this growth arrest is reversible. This question was addressed using non-small cell lung cancer models exposed to the cancer chemotherapeutic drug, etoposide. Senescent cells that were sorted, identified by β-galactosidase staining and alterations in morphology, isolated by flow cytometric cell sorting based on C12FDG staining, and real-time live microscopy were found to be capable of recovering proliferative capacity. Autophagy, monitored by vacuole formation, SQSTM1/p62 degradation, and LC3BII generation did not interfere with either the senescence arrest or proliferative recovery and was nonprotective in function (i.e. autophagy inhibition via both pharmacological and genetic strategies had negligible impact on the response to etoposide).These observations argue against the premise that (chemotherapy-induced) senescence is irreversible and indicate that therapy-induced senescence may ultimately be a transient process in that at least a subpopulation of tumor cells can and will remain metabolically active and recover proliferative capacity independently of autophagic turnover. We therefore propose that dormant tumor cells may be capable of prolonged survival in a state of autophagy/senescence and that disease recurrence may reflect escape from this senescence-arrested state.
CSR communication in Japan: the case of Kikkoman
Authors: Takano Kaori 
Published: January 2017

Purpose
The purpose of this paper is to examine Kikkoman’s corporate social responsibility (CSR) communication with public schools associated with a new food education law in Japan. It describes how an internationally recognized soy sauce maker, Kikkoman, effectively entered a previously untapped market, public schools in Japan, and improved its corporate image using the vehicle of CSR activity.

Design/methodology/approach
Three traditional qualitative data sources were utilized: documents, interviews, and observations.

Findings
Social, political, economic, and environmental factors pushed Kikkoman to create a soy sauce lesson as a new CSR activity, which created challenges in corporate communication. The company, with the help of government, overcame the difficulties and was able to effectively communicate its CSR and improve its corporate image while promoting its signature product to children. This case presents a successful public relations strategy using a stakeholder approach as a framework.

Research limitations/implications
It is difficult to generalize the findings to CSR communication in Japan because this is a single case study with interviews with one company representative and observations at two schools.

Practical implications
First, collaboration between business people and public schools teachers is on the rise. This may open new opportunities for socially responsible corporations to engage in effective public relations activity through CSR in Japan. Second, human resource development in CSR activities is strategic and employees can play a pivotal role in Japanese CSR.

Originality/value
This paper examines the unique activities of a Japanese food industry leader from multiple data sources including observations of actual corporate behaviors in schools.
Understanding social media governance: seizing opportunities, staying out of trouble
Authors: van den Berg Annelieke C. , Verhoeven Joost W.M. 
Published: January 2017

Purpose
The rise of social media such as Facebook and Twitter has provided employees with means to share work-related information. Increasingly, social media governance policies are implemented to negotiate the risks and opportunities of such behaviors. The purpose of this paper is to unveil the motivations behind managers’ attempts to govern these behaviors.

Design/methodology/approach
Semi-structured interviews were conducted with ten communication managers of various organizations. Higgins’ regulatory focus theory (Higgins, 1997) was used to examine whether managers adopted a prevention or promotion focus to social media, and whether regulatory focus affected the measures taken toward social media governance.

Findings
Prevention and promotion foci were both observed among managers, and differed per communication model. Managers who employed dialogic models of communication were primarily promotion-focused and emphasized opportunities to improve stakeholder relations, while managers who employed one-way models were primarily prevention-focused and highlighted the risks of social media (e.g. the risk of employees publishing messages that contradict corporate communication and confuse stakeholders). Social media governance differed depending on regulatory focus. In the prevention scheme managers usually attempted to regain control by restricting social media to private use only, while in the promotion focus managers trained and facilitated employees for work-related social media use, to various extends.

Originality/value
By examining the interplay of regulatory focus, communication models and governance, this paper sheds light on the rationale behind social media governance policies that are implemented in organizations.
Analyzing the factors for implementation of green supply chain management
Authors: Singh R.K. , Rastogi Sanjay , Aggarwal Mallika 
Published: January 2017

PurposeIn the present context of a globalised economy, market requirements are changing regularly in term of product cost, delivery time, safety and environmental issues. Apart from conventional measures, environmental factors have become an integral part of performance measurement system. This study aims to analyse major barriers and factors in green supply chain (GSC) management implementation.Design/methodology/approachThe present study has tried to identify barriers and factors for green supply chain management (GSCM) based on literature review. Factors for GSCM have been modelled by interpretive structural modelling (ISM) approach.FindingsBased on literature review, 12 factors have been identified. It has been observed that top management commitment, integration among supply chain members, vendors’ development, environmental friendly packaging and transportation, reverse logistic management and development of a green performance measurement system are major drivers for successful implementation of GSCM.Research Limitations/implicationsOrganisations need to follow a proactive approach for taking GSC initiatives. For generalisation of findings, empirical study and some case studies need to be carried out.Originality/valueFindings of this study will help organisations in strategy formulation for GSCM and successful implementation for sustainable competitiveness.
Grey relational analysis between Turkey’s macroeconomic indicators and domestic savings
Authors: Duran Engin , Uzgur Duran Burcu , Akay Diyar , Boran Fatih Emre 
Published: January 2017

Purpose
It is of great importance for economy policy makers to comprehend the relationship between macroeconomic indicators and domestic savings, and to find out which indicator is more determinative on the dynamics of domestic savings. The purpose of this paper is to analyze the degree of relationship between Turkey’s domestic savings and selected macroeconomic indicators.

Design/methodology/approach
To examine the relationship, grey relational analysis (GRA) is applied together with the entropy method to determine the weight of the indicators according to the information level they provide. The analysis covers the data of the period from 1990 to 2014. In practice, however, the data set is used by dividing into two separate periods including before and after the 2001 crisis.

Findings
The results indicate that the unemployment rate and the gross domestic product (GDP) per capita growth stand out with a relatively high degree of relationship for the period before 2001. When examining the post-2001 period, current balance ratio and GDP growth are ascertained as indicators which have a high degree of relationship with domestic savings.

Practical implications
These indicators have different aspects affecting both public and private savings. Therefore, it may be beneficial to concentrate on these indicators when designing a policy in order to increase the domestic saving rate.

Originality/value
There are many econometric models used for investigating Turkey’s macroeconomic indicators and domestic savings causality. But before now, any study which investigates relationship between macroeconomic indicators and domestic savings by GRA could not be encountered. Using one of the newest developed theories (the grey systems theory) for this subject is the significance of this research.
Population forecast of Anhui province based on the GM(1,1) model
Authors: Gao Hong , Yao Tianxiang , Kang Xiaoru 
Published: January 2017

Purpose
The purpose of this paper is to predict the population of Anhui province. The authors analyze the trend of the main demographic indicators.

Design/methodology/approach
On the basis of the main methods of statistics, this paper studies the tendency of the population of Anhui province. It mainly analyzes the sex structure and the age structure of the current population. Based on the GM(1,1) model, this paper forecasts the total population, the population sex structure, and the population age structure of Anhui province in the next ten years.

Findings
The results show that the total population was controlled well, but there have been many problems of the population structure, such as the aging population, high sex ratio, heavy social dependency burden, and the declining labor force.

Social implications
This paper forecasts the main indexes of the population of Anhui province and provides policy recommendations for the government and the relevant departments.

Originality/value
This paper utilizes data analysis method and the grey forecasting model to study the tendency of the population problems in Anhui province.
Explanation of terms of grey clustering evaluation models
Authors: Liu Sifeng , Yang Yingjie 
Published: January 2017

Purpose
The purpose of this paper is to present the terms of grey clustering evaluation models.

Design/methodology/approach
The definitions of basic terms about grey clustering evaluation models are presented one by one.

Findings
The reader could know the basic explanation about the important terms about various grey clustering evaluation models from this paper.

Practical implications
Many of the authors’ colleagues thought that unified definitions of key terms would be beneficial for both the readers and the authors.

Originality/value
It is a fundamental work to standardise all the definitions of terms for a new discipline. It is also propitious to spread and universal of grey system theory.
Estimating a civil aircraft’s development cost with a GM(1,N) model and an MLP neural network
Authors: Xie Nai-ming , Yin Song-Ming , Hu Chuan-Zhen 
Published: January 2017

PurposeThe purpose of this paper is to study a new approach by combining a multilayer perceptron neural network (MLPNN) algorithm with a GM(1,N) model in order to estimate the development cost of a new type of aircraft.Design/methodology/approachFirst, data about developing costs and their influencing factors were collected for several types of Boeing and Airbus aircraft. Second, a GM(1,N) model was constructed to simulate development costs for a civil aircraft. Then, an MLPNN algorithm was added to optimize and revise the simulative and forecasting values. Finally, a combined approach, using both a GM(1,N) model and an MLPNN algorithm was adopted to forecast development costs for new civil aircraft.FindingsThe results show that the proposed approach could do the work of cost estimation for new types of aircraft. Rather than using a single model, the combined approach could improve simulative and forecasting accuracy.Practical implicationsScientific cost estimation could improve management efficiency and promote the success of a new type of civil aircraft development. Considering that China’s civil aircraft research and development is at its very beginning stages, only very limited data could be collected. The development costs for civil aircraft are affected by a series of factors. The approach outlined by this paper could be applied to development cost estimations in China’s civil aircraft industry.Originality/valueThe paper has succeeded by constructing a cost estimation index system and proposing a novel combined cost estimation approach comprised of a GM(1,N) model and an MLPNN. It has undoubtedly contributed to improving the accuracy of cost estimations.
The role of tolerance of ambiguity on ethical decision-making students
Authors: Moardi Mahdi , Salehi Mahdi , Marandi Zakiyeh 
Published: January 2017

Purpose
This paper aims to investigate the role of affect and tolerance of ambiguity on ethical decision-making of management and accounting students.

Design/methodology/approach
Weisbrod’s (2009) questionnaire on ethical decision-making in individual and organizational situations, McDonald’s (1970)16-factor questionnaire on tolerance of ambiguity and Watson et al.’s (1988) Positive and Negative Affect Schedule were used to study the students’ views toward research hypotheses. The population used in this study includes graduate and PhD students of accounting and management during the academic year 2014-2015. The number of samples is 398 and sample members selected using simple random sampling method. Hypotheses test using structural equation modeling in the AMOS software version 18.

Findings
Results of hypotheses shows that individual characteristics of positive and negative affect and tolerance of ambiguity have no effect on accounting students’ ethical decision-making, but there is a significant positive relationship between management students’ negative affect and ethical decision-making, and a significant negative relationship between management students’ increased level of tolerance of ambiguity and ethical decision-making. The findings also show that affect (positive and negative) and tolerance of ambiguity have no interactive effect on accounting students’ ethical decision-making, whereas among students of management, there is a significant relationship between interactive effect of negative affect and tolerance of ambiguity on ethical decision-making. The results show that there is a significant difference between students of management and accounting based on negative effects and tolerance of ambiguity on ethical decision-making.

Originality/value
The current paper is almost the first paper which was conducted in developing countries.
Unique aspects of the Islamic microfinance financing process
Authors: Wulandari Permata , Kassim Salina , Adhi Kasari Sulung Liyu , Iwani Surya Putri Niken 
Published: January 2017

Purpose
This paper aims to highlight on the unique aspects of Islamic microfinance based on the experience of Baitul Maal Wa Tamwil (BMT) in Indonesia.

Design/methodology/approach
It adopts the content analysis approach and focuses on three phases of financing, namely, pre-financing, financing and post-financing using coding and model buildings. Data are collected through in-depth interview with a sample of representatives of BMTs that offer product based on Islamic principle for the poor located in Jakarta, Bogor, Depok, Tanggerang and Bekasi (JABODETABEK), Sulawesi Selatan, Yogyakarta and Nusa Tenggara Barat (sample chosen based on the most concentrated areas of Islamic microfinance that offered product based on Islamic principles). Ultimately, a model based on the unique features of Islamic microfinance will be developed based on the findings of the content analysis.

Findings
The proposed model incorporates the peculiarities of the poor people in pre-financing, financing and post-financing activities of micro-financing products to serve as a reference for policy makers. The paper also found that each region has unique product preferences depending on the poor’s characteristics.

Research limitations/implications
This study is only conducted in four areas with BMT representation, namely, Jakarta, Bogor, Depok, Tangerang, Bekasi (often abbreviated as JABODETABEK), Sulawesi Selatan, Yogyakarta and Nusa Tenggara Barat) in Indonesia. Despite the limited scope, the findings have wide applications to the Islamic microfinancing in general.

Originality/value
The paper adds value to the literature on Islamic microfinance by enabling researchers and practitioners to understand the model of three step financing (pre-financing, financing and post-financing) in Islamic microfinance in Indonesia. Although not a new issue, the paper provides the practice of pre-financing, financing and post-financing processes which may differ from the practices of Islamic microfinance in other settings because of different cultural influences unique to every region.
The hybrid identity of micro enterprises
Authors: Nunes Francisco G. , Anderson Janet E. , Martins Luis M. , Wiig Siri 
Published: January 2017

PurposeThe purpose of this paper is to examine the effect of ownership of community pharmacies on the perception of organizational identity and its relationships with organizational performance.Design/methodology/approachA survey was carried out on a sample of pharmacists working in community pharmacies in Portugal. The sample comprised 1,369 pharmacists, of whom 51 percent were owner-managers. Measures of pharmacies’ normative (community health oriented) and utilitarian (business oriented) identities, identity strength (clear and unifying), substantive (stockholder focused) and symbolic (society focused) performance were included.FindingsBoth owners and employed pharmacists rated the normative identity of pharmacies higher than the utilitarian identity. Compared with employed pharmacists, owners perceive a lower level of utilitarian identity, the same level of normative identity, and higher levels of identity strength. Normative identity and identity strength predicted symbolic performance. Normative and utilitarian identities and identity strength predicted substantive performance. The relationship between utilitarian identity and substantive performance was significant among owner pharmacists but not among employed pharmacists.Research limitations/implicationsThe limitations include the use of perceptive measures and the focus on the individual level of analysis.Practical implicationsIn order to improve pharmacies’ performance, pharmacists who manage community pharmacies are challenged to reconcile tensions arising from the co-existence of business and community health identities and from their own agency (self-serving) and stewardship (altruistic) motives.Originality/valueThis study draws on institutional, identity and stewardship theories to understand how pharmacists, owners and employees, view the identity of community pharmacies and how identity relates to organizational performance.
Female entrepreneurial networks and foreign market entry
Authors: Rosenbaum Gitte O. 
Published: January 2017

PurposeThe purpose of this paper is to explore the role of networks in the 116 foreign market entries (FMEs) of women-owned small businesses.Design/methodology/approachA multiple case study based on semi-structured interviews with eight female entrepreneurs in the Danish fashion design industry.FindingsThe results show that contrary to the traditional emphasis placed on the role of networks in the internationalization literature, the focal female entrepreneurs only spartanly used networks to expand into new foreign markets. Indeed, networks were used in only 24 of the 116 FMEs. The respondents largely attributed this reluctance to use networks to work-life balance issues and misgivings about knowledge misappropriation. In contrast, the focal entrepreneurs strongly attested to the decisive role played by information and communication technology (ICT) in allowing firms to enter foreign markets without incurring the costs of network membership or compromising their work-life balance.Research limitations/implicationsThe present study’s findings suggest that ICT has a much stronger role in the FME of firms than previously envisioned.Practical implicationsThe study’s findings also have important implications for policymakers and practitioners charged with promoting the international growth of female entrepreneurial ventures.Originality/valueThis study is the first of its kind to explore the way in which female entrepreneurs enter new foreign markets.
Formal compensation practices in family SMEs
Authors: Michiels Anneleen 
Published: January 2017

PurposeBy investigating the use of formal compensation practices in family small- and medium-sized enterprises (SMEs), the purpose of this paper is to provide important new insights in these issues for academics, as well as family business practitioners, prospective applicants and financiers of family businesses. Moreover, this study includes a contingency that allows to explore heterogeneity across family businesses in their use of formal compensation practices: the CEO type.Design/methodology/approachA survey of 124 small- and medium-sized Belgian family businesses to explore the use of formal compensation practices is analyzed by the author.FindingsThe results support the hypothesis that family firms with a family CEO adopt significantly less formal compensation practices than their counterparts that are led by a non-family CEO.Research limitations/implicationsGeneralizing the findings of this study must be taken with care, as the findings are based on a cross-sectional sample of family SMEs in one country, Belgium. Future research can build on these findings with studies on larger samples in other countries.Practical implicationsThis study may be interesting for family business practitioners and consultants, as it provides insight in the actual use of formal compensation practices that are recommended as a best practice in numerous practitioner handbooks. Also, the results of this study might be important for prospective applicants and financiers, since the compensation system is an important communication device to signal legitimacy to external stakeholders.Originality/valueCompensation issues are among the main challenges SMEs, especially family firms, face. Despite the clear importance of this matter, academic interest has been rather limited. This paper therefore displays sound descriptive survey results and empirically investigates the determinants of the use of formal compensation practices in Belgian family SMEs by distinguishing between different types of family businesses.