bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Artificial Intelligence-related Superordinate Concepts and Terminological Variation in the English and Ukrainian Languages
Authors: Mikelionienė Jurgita , Ponomarevskyi Artemii 
Published: October 2024

This research is aimed at analyzing the artificial intelligence-related superordinate concepts in the English and Ukrainian languages and explaining the relevance of using terminological variations from the field of artificial intelligence (AI) in a particular context on the example of translation from English (EN) into Ukrainian (UK). The essence of terminological variation as a linguistic phenomenon and possible reasons for its emergence are described. Terminological variants in the newly established field of artificial intelligence appear either in both EN and UK, or in one of those due to a specific understanding of objects and ideas in a particular language. The main concepts in EN and UK, which may include both terms and variants, in the field of AI are identified. On the example of building a basic concept model with the respect to the core concept of AI, the differences in understanding similar concepts in the EN and UK are explained. Considering these differences, the contextually motivated ways of using the artificial intelligence-related terms or terminological variants in the examples of translation from EN into UK are provided.
Nivel de conocimiento sobre Ddiabetes Mmellitus tipo 2 y adherencia al tratamiento en la población hondureña
Authors: Galeas Calleja Norma Isabel , Raudales Moncada Julio César , Carías Díaz Juan Pablo 
Published: October 2024

Introducción: En Honduras, 495 011 personas fueron diagnosticadas con diabetes mellitus tipo 2 (DMT2) durante el año 2015; este último registro existente indica una afectación de entre el 7,0 % y el 10,0 % de la población. La educación diabetológica es fundamental para el control adecuado de dicha enfermedad, por lo tanto, el propósito del estudio es describir el nivel de conocimiento sobre la diabetes mellitus tipo 2 y la adherencia al tratamiento en pacientes que asistieron al Instituto Nacional del Diabético en los meses de enero y febrero del año 2023, en Tegucigalpa, Honduras. Metodología: Es un estudio de tipo transversal correlacional con un enfoque no experimental. De una población de 20 500 pacientes se obtuvo una muestra de 378 individuos para análisis. Los participantes fueron seleccionados por un método no aleatorizado, estos respondieron el cuestionario Diabetes Knowledge Questionnaire (DKQ 24) para la evaluación del nivel de conocimiento y, para el de apego al tratamiento, el test de Morisky-Green. Resultados: 266 (70,4 %) personas poseían un nivel de conocimiento intermedio sobre la enfermedad y 193 (51,1 %), quienes fueron mayoría, refirieron una adherencia inadecuada al tratamiento. Al analizar la relación entre ambas variables, estas poseen una significancia estadística de p 0,007. Conclusiones: Se deben reforzar los conocimientos sobre DMT2 entre los hondureños tomando en cuenta las áreas deficientes; así como profundizar en los factores que intervienen en la falta de adherencia al tratamiento.
A traditional medicinal food <i>Arum rupicola</i> (Kardeh) ameliorates thioacetamide-induced hepatotoxicity in animal model: Role of PCNA/Bax, oxidative stress, and inflammatory cytokines
Authors: Al-Qaisi Talal Salem , A.J. Jabbar Ahmed , Ubeid Muhsin H. , Al-Qaaneh Ayman M. , Mothana Ramzi A. , Hawwal Mohammed F. , Hassan Rawaz Rizgar , Ameen Abdulla Mahmood , Ismael Saleh Musher , Abdul-Samad Ismail Parween , Hasson Sidgi 
Published: October 2024

Nutraceuticals are major contributors to human health because of their modulatory effects on various physiological and pathological processes. Arum rupicola (Kardeh) is a traditional medicinal food used for many gastrointestinal and enzymatic disorders. The present study evaluates the acute toxicity and hepatoprotective effects of methanolic extracts of Arum rupicola (MEAR) in rat with thioacetamide (TAA)-induced liver injury in rat. Thirty Sprague-Dawley rats were divided into five groups: Group A, normal control, and group B, TAA control groups were treated orally with 10% tween 20; group C reference rat received daily of 50 mg/kg silymarin drug; Groups D and E rat received daily doses of 250 mg/kg and 500 mg/kg MEAR, respectively. In addition, group B–E received three injections of 200 mg/kg TAA weekly for 60 days. The safety evaluation of MEAR revealed nontoxic effects at 2,000 and 5,000 mg/kg dosage in rat. TAA inoculation provoked significant hepatotoxic alterations indicated by increased hepatocyte proliferation, endothelial tissue injury, ambiguous nucleus, and elevated cytoplasmic vacuoles. TAA treatment initiated increased inflammatory response and necrosis process in different areas of hepatic tissues. Meanwhile, MEAR treatment showed significant prophylaxis against TAA-induced hepatotoxicity, supported by its suppressing actions on oxidative stress, and apoptotic and inflammatory mediators. MEAR treatment significantly down-regulated proliferating cell nuclear antigen (PCNA) in both liver and spleen parenchymal tissues, lowered pro-apoptotic Bcl-2-associated X (Bax) proteins, reduced inflammatory and redox mediators, lowered transforming growth factor-beta tissue expression and malondialdehyde content, while, increased antioxidants (superoxide dismutase, catalase, and glutathione peroxidase). The outcomes provided significant hepatoprotective potential of MEAR mediated by its modulatory effects on several cellular pathways, making it a viable source of a potent pharmaceutical discovery.
A Comparative Study On the Impact of Wet and Dry Aging On the Quality of Romanian Spotted and Black Angus Beef
Authors: GLIGA Maria-Cristina , LEÓN-CAMACHO Manuel , CĂTUNESCU Giorgiana M. , ROTAR Ancuța Mihaela , POP Carmen Rodica , DULF Francisc Vasile , BODEA Ioana M. , ODOCHEANU Răzvan , TOFANĂ Maria 
Published: October 2024

The escalating demand for meat driven by the increase of the global population requires substantial advancements in the beef sector. Among the various cattle breeds bred for meat, Black Angus (BA) is renowned for its adaptability and commendable performance in meat production. In contrast with BA, the Romanian Spotted (RS) is a local study breed which constitutes a significant proportion of Romania's livestock and it could become an alternative to BA in a localized market. This study aims to assess the suitability of RS beef to dry-ageing in comparison to BA by investigating the impact of dry-aging (DA) and wet-aging (WA) techniques on two distinct anatomical parts, specifically Longissimus thoracis (LT) and Longissimus lumborum (LL), of each breed. The quality of the aged products was assessed in terms of microbiological characteristics, fatty acid composition and the changes in their values at the end of the ageing process compared with the initially quality of the raw meat. The study showed significant changes in the fatty acid composition profile after ageing, for both types of ageing, and for both breeds. Furthermore, this study highlights the possibility of valorizing local breeds in the production of aged beef.
Introduction pages, NBHA-CN 52(3), 2024
Authors: SESTRAS Radu E. 
Published: October 2024

The papers published in Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Issue 3, Volume 52, 2024 represent new exciting research in different topics of life science, respectively in plant science, horticulture, agronomy, crop science, and forestry. Among the interesting articles, we invite you to find news about: Genetic improvement of drought stress tolerance in maize, recent advancements and future research direction; Exploring ecotypic plant adaptations and the influence of microbiota on mitigating environmental challenges; Unveiling the genetic landscape: Exploring the SSR-based genetic architecture and amino acid dissection of Gossypium barbadense and G. darwinii genomes; Role of iron oxide nanoparticles in maize (Zea mays L.) to enhance salinity stress tolerance; Differential physiological responses to salt stress in rice landraces in Thailand; Effects of chemical regulation on the growth, yield and fiber quality of cotton varieties with different plant architectures; Separation and identification of individual anthocyanins from the petals of some rose cultivars; Comparative analysis of seed morphology in genus Scutellaria L.; Effects of chemical fertilizer nitrogen substitution with rapeseed cake on microbial community in tobacco rhizosphere soil; Particle film treatments on ‘Assyrtiko’ grapevines enhance physiology and grape attributes in Santorini Island; Nutrimental modifications in blueberry (Vaccinium corymbosum L.) caused by vanadium supply; Exploring the effects of the assisted transfer of European beech (Fagus sylvatica L.) provenances in the Romanian Carpathians.
Differential chemoproteomic analysis of RRS-1 candidate molecule and molecules of several nonsteroidal anti-inflammatory drugs
Authors: Galenko-Yaroshevsky P. A. , Torshin I. Yu. , Gromov A. N. , Gromova O. A. , Suzdalev K. F. , Murashko R. A. , Zelenskaya A. V. , Zadorozhniy A. V. , Glechyan T. R. , Simavonyan G. V. , Muhammad E.M. I. 
Published: October 2024

Background. To plan effective and safe pharmacotherapy for inflammation and pain, it is important to evaluate the mechanisms and spectrum of action of nonsteroidal anti-inflammatory drugs (NSAIDs), including their effects on human proteome.Objective: to identify and evaluate the most significant specific differences of candidate molecule RRS-1 (N-{(Z)-2-(1-methyl-1H-indol-3-yl)1-[(propylamino)carbonyl]vinyl}benzamide) from other NSAIDs through differential chemoreactome analysis.Material and methods. Chemoproteomic modeling of pharmacological effects of RRS-1 molecule and a number of well-known NSAIDs (diclofenac, nimesulide, ketorolac) on human proteome was carried out on the basis of numerical prediction algorithms over the space of heterogeneous feature descriptions, developed in the topological approach to recognition by Yu.I. Zhuravlev and K.V. Rudakov scientific school.Results. Significant differences in the effects of the studied molecules were found for 1232 proteins of human proteome. The features of assessing interactions of the studied molecules with 47 target proteins, which most distinguished the effects of RRS-1 molecule from all others were identified. RRS-1 could activate adenosine and dopamine receptors, cannabinoid receptor 2 and GABAA receptor to a greater extent than other molecules. Activation of these receptors corresponded to anti-inflammatory, anti-nociceptive and neuroprotective effects. RRS-1 could preferably inhibit a number of pro-inflammatory proteins, receptor bradykinin 1, metabotropic glutamate receptor 5, matrix metalloproteinases 8, 9, 12, and blood coagulation factor X. Additionally, RRS-1 molecule showed preferable inhibition of a number of kinases targeted in antitumor and anti-inflammatory therapy. RRS-1, less than other studied molecules, interacted with the receptors of vitamin D3, thyroid hormone, acetylcholine, cannabinoids and opioids, orexin, and various metabolic enzymes, which is important in assessment of the safety of using drugs based on this molecule. RRS-1 characteristically exhibited a moderate profile of antivitamin action: the total score of vitamin and mineral loss (7.4±3.7) was significantly less in comparison to diclofenac (11.7±4.5) and was actually on the same level as nimesulide (6.9±3.7) and ketorolac (6.7±3.6).Conclusion. Chemoreactomic and chemoproteomic profiling of RRS-1 candidate molecule provided pre-experimental assessments of its efficacy and safety through modeling interactions with the human proteome.
Review of open libraries for pharmacoeconomic analysis in R environment
Authors: Lackman I. A. , Sladkov R. I. , Timiryanova V. M. 
Published: October 2024

Background. To reveal the full complexity of the relationship between medical intervention and disease outcome, new methods of analysis and modeling are actively being developed, and tools are becoming more complex, for the use of which it is important to understand their limitations and advantages.Objective: conducting a critical review of the main open-source packages in R environment for conducting pharmacoeconomic analysis.Material and methods. The selection of libraries used for pharmacoeconomic analysis in the R environment was carried out based on the keywords “health economic”, “DALY”, “QALY” in the CRAN repository. Only libraries that were valid on the date of the review were included in the study. The selected 10 R software libraries for pharmacoeconomic analysis were reviewed from the standpoint of the number of tools they support, the format of the data used, the possibilities of visualizing results and generating reports, the presence of vignettes and the possibilities of parallelizing calculations.Results. The selected libraries can be divided into three classes: packages for calculating various quality of life indices, libraries for calculating indicators and indices of economic effectiveness of medical interventions (DALY, QALY, ICER), libraries for performing sensitivity analysis of the effect of medical interventions based on decision tree algorithms and Markov models. The libraries “heemod”, “hesim”, “rdesign” allow building simple Markov and semi-Markov models, but preference should be given to “heemod” due to the presence of vignettes. To conduct an analysis using cohort Markov models, partitioned survival models, it is recommended to use the “hesim” library, if there are gaps in the results, it is recommended to use “missingHE”. The “rdesigin” library allows building decision trees indicating the risk of developing certain conditions and the cost of therapy. The “survHE” library for survival analysis, used specifically in health economics, allows you to carry out probabilistic sensitivity analysis based on survival models. To calculate the survival models themselves to identify predictors of a patient's transition from one health state to another, you will need to additionally install the “flexsurv” library. To visualize the results of pharmacoeconomic modeling, you should additionally install the “diagram” and “ggplot2” libraries. Conclusion. The conducted critical review of open source libraries in R environment can serve as a navigator for choosing a tool for performing pharmacoeconomic analysis.
Relationships Between Upper-Plate Structure, Mantle Wedge Melting, and Fore-Arc Sliver Transport in the Nicaraguan Subduction Zone
Authors: Carrero Mustelier Emily , Fischer Karen M. , Hua Junlin , Gama Isabella , La Femina Peter C. , Higgins Machel 
Published: October 2024

Abstract
This study images the base of the upper-plate lithosphere in the Nicaraguan subduction zone using common conversion point stacking of Sp phases and explores the relationships between deep upper-plate structure, subduction zone melting processes, and the arc-parallel transport of the Central American fore-arc sliver. We observe the negative velocity gradient associated with the upper-plate lithosphere–asthenosphere boundary in the Nicaraguan back-arc at depths of 60–80 km. However, the amplitude of the lithosphere–asthenosphere velocity gradient diminishes beneath the arc, consistent with a reduction in the shear-wave velocity of the deep upper-plate lithosphere. This zone lies above mantle wedge velocity anomalies which indicate upward-migrating partial melt, suggesting that ascending melt has altered and weakened the lithospheric mantle of the upper plate. In northwestern Nicaragua, the boundary of the Central American fore-arc sliver and the Caribbean plate, which is marked by a northeast decrease in geodetically measured arc-parallel surface velocities, lies above the northeast increase in the amplitude and localization of the lithosphere–asthenosphere velocity gradient. This correlation indicates that the kinematic margin of the Central American fore-arc sliver corresponds to a structural boundary that extends throughout the upper plate, and that is influenced by melt ascending from the mantle wedge.
Escape of SARS-CoV-2 Variants KP.1.1, LB.1, and KP.3.3 From Approved Monoclonal Antibodies
Authors: Planas Delphine , Staropoli Isabelle , Planchais Cyril , Yab Emilie , Jeyarajah Banujaa , Rahou Yannis , Prot Matthieu , Guivel-Benhassine Florence , Lemoine Frederic , Enouf Vincent , Simon-Loriere Etienne , Mouquet Hugo , Rameix-Welti Marie-Anne , Schwartz Olivier 
Published: October 2024

Background: First-generation anti-SARS-CoV-2 monoclonal antibodies (mAbs) used for prophylaxis or therapeutic purposes in immunocompromised patients have been withdrawn because of the emergence of resistant Omicron variants. In 2024, 2 novel mAbs, VYD222/Pemivibart and AZD3152/Sipavibart, were approved by health authorities, but their activity against contemporary JN.1 sublineages is poorly characterized.
Methods: We isolated authentic JN.1.1, KP.1.1, LB.1, and KP.3.3 viruses and evaluated their sensitivity to neutralization by these mAbs in 2 target cell lines.
Results: Compared to ancestral strains, VYD222/Pemivibart remained moderately active against JN.1 subvariants, with a strong increase of 50% Inhibitory Concentration (IC50), reaching up to 3 to 15 µg/mL for KP.3.3. AZD3152/Sipavibart neutralized JN.1.1 but lost antiviral efficacy against KP.1.1, LB.1, and KP.3.3.
Conclusions: Our results highlight the need for a close clinical monitoring of VYD222/Pemivibart and raise concerns about the clinical efficacy of AZD3152/Sipavibart.
Book Competitions in Siberia and the Far East in the 1990–2020s
Authors: Alshevskaya O. N. , Androsova N. S. 
Published: October 2024

The purpose of the article is to present the results of the book competition movement in Siberia and the Far East in the last three decades, to identify the trends of its evolution, to determine problems and prospects.The research methodology bases on a combination of formal-logical and comparative-historical methods with the analysis of data from various sources. The forms of competitions are identified: universal and special. It has been determined that either only local publications, or also books published in other regions, can participate in competitions. Long-term (“Book of the Year of the Republic of Buryatia” (Ulan-Ude, since 1997), “Best Book of the Year” (Vladivostok, since 1997), “Best Book of Altai” (Barnaul, since 2006)) and recently emerged regional projects are characterized. The authors have analyzed the contribution to the organization of competitive projects made by regional authorities, libraries, educational institutions, public organizations, etc. The most common nominations of universal competitions and specialized topics have been determined. Attention is focused on the importance of an integrated and systematic approach to transforming festivals into a full-cycle creative system. It has been stated that, in general, expert-competitive activities have a multifaceted, multifactorial impact on the sociocultural landscape of the region, contributing to strengthening and development of the beneficial influence of the book on the aesthetic, moral and legal consciousness of the society.
Book Culture Ecology: Looking for a Concept
Authors: Sokovikov S. S. , Askarova V. Ya. 
Published: October 2024

The authors have attempted to comprehend the ecological component of book culture, its importance for social development and evolution of human needs. This problem updating is closely connected with the modern state of book culture, characterized by minimization of state management, absolutist commercial approach, appearance of the great amount of players on the book market, multiformity of book products and modes of their advancement, transformation and re-estimation of activities of institutes of reading infrastructure, etc. It demands, according to our viewpoint, re-comprehension of the book culture state, inclusion of ecological criteria into its functioning, which presupposes, most of all, social attention to its various manifestations due to their correspondence to humanist values and national interests. The aim of the article is to reveal and justify the “book culture ecology” concept.The formation of ideas about this concept was ­carried out in the context of the paradigm of cultural ecology through clarification of its content and main vector directions. The article justifies the importance of book culture and considers different approaches to its treatment. It is shown that the eco-cultural aspects of book culture are an organic embodiment of its static and dynamic characteristics. In the progress of the study, the authors used terminological and operational analysis as well as structuralfunctional approach. Eco-cultural approach to different phenomena of book culture defines ethical norms of functioning of book-publishing industry different actors, determines their most important for the society principles of activity. Moreover, the study has defined difficulties of developing book culture ecological compatibility criteria. The result of the analysis has manifested itself in the generalized definition of the concept under study.
Unpublished Sources in the Archive of the Samizdat and Non-traditional Printing Sector of the State Public Scientific Technological Library of the Siberian Branch of the Russian Academy of Sciences
Authors: Shatovkin V. V. 
Published: October 2024

The aim of the article is to present the structure of the common archive of the Samizdat and Non-traditional Printing Sector of the Laboratory of Book Studies of SPSTL SB RAS formation on the ­example of the main storage units – personal collections of writers, artists, cultural figures and musicians. It provides classification of the existing unpublished sources in the sector’s collections, analyzes authorial materials, dedications, autographs, drawings and markings, mentions of the alternative printing process authors and participants in periodicals and correspondence. The article describes the sources of samizdat and non-traditional printing, existing in the sector, reveals the content of the main thematic directions. It characterizes archival units on the examples of alternative book publishing, various forms of samizdat, ephemera, ego-documents, fragments of personal libraries, examples of periodical printing. It also offers the classification of personal collections based on temporal periodization, thematic and territorial characteristics. The analysis of the content of the presented sources bases on the personal collections of M. Baturin, I. Akhmetiev, V. Ivaniv, O. Volov, E. Shurygin, E. Iordansky, A. Chekanov, as well as various unofficial creative communities and groups. Special attention is paid to the formation of communication chains and links between authors in the informal cultural environment, in the field of samizdat and alternative book publishing from the 1960s to the 2010s that clarifies the criteria of such ties.