bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Social Support Subtypes Are Associated With Executive Function in Middle-Aged and Older Adults: Findings From the Baseline Comprehensive Cohort of the Canadian Longitudinal Study on Aging
Authors: Rutter Emily C. , Oremus Mark , Maxwell Colleen J. , Tyas Suzanne L. 
Published: September 2024

Objectives We investigated whether functional social support—the degree to which one perceives support is available when needed—is associated with executive function, a key cognitive domain for everyday functioning and adaptation to change. Methods Analyses ( n = 23,491) utilized cross-sectional data from the Comprehensive cohort of the Canadian Longitudinal Study on Aging (CLSA), a population-based study of community-dwelling adults aged 45–85 years. Executive function was assessed by neurocognitive battery. Perceived social support was measured using the 19-item Medical Outcomes Study-Social Support Survey. Logistic regression models were adjusted for sociodemographic, health, and social covariates. Results Positive social interactions as well as affectionate and emotional/informational functional social support were positively associated with executive function. Discussion Social support plays an important role in cognitive health. Diversifying social programming beyond tangible social support to target other subtypes of support may help preserve executive function in middle-aged and older adults.
Modelling and characterising FFF process of semi-crystalline polymers: Warpage formation and mechanism analysis
Authors: Yu Yuesheng , Jiang Bingnong , Chen Yuan , Ye Lin 
Published: September 2024

Fused filament fabrication (FFF) is commonly utilised for 3D printing of semi-crystalline polymers, i.e., polypropylene (PP), while warpage deformation can often be observed in the printed products, with significantly reduced surface quality and mechanical properties. This study develops computational models for predicting rectangular boxes made of PP with different thicknesses under the FFF process to study the stress concentration and warpage mechanisms during 3D printing. Numerical models were established based on heat transfer, thermoelasticity, and crystallisation kinetics, with an activating elemental approach to calculate the FFF process of PP. The numerical models were validated with repetitive printing tests to study the mechanisms and relationships of stress conditions and warpage formation in PP boxes under FFF. The results show that the boxes with the thinnest thickness exhibited mostly severe warpage deformation (6.8 mm/5.9 mm in experiment and simulation, respectively), which is much more than that of the thickest box (1.3 mm/1.6 mm in experiment and simulation, respectively). The average crystallinity of the three boxes increases as the box thickness increases, but to a lesser extent. In terms of residual stress, the thinner box has a smaller residual stress (25.1 MPa, almost 45% of the thicker box).
Experiences and Supportive Care Needs of Latinx Millennial Caregivers
Authors: Cleary Catie , Dupree Galilea , Welling Anna , Hernandez Janice F. , Cuevas Heather , Thomas Michael , Peterson Neil , Horner Sharon D. , Thomas Hebdon Megan 
Published: September 2024

Introduction: Latinx Millennial caregivers are an understudied minority group in the United States. Due to life stage and cultural values, these caregivers struggle to balance conflicting priorities with career, family, and caregiving. They also face systemic barriers and healthcare disparities. Methods: Participants ( N = 29) were recruited locally and nationally. Qualitative data were collected using five focus groups and one individual interview. Interviews were analyzed by seven coders using thematic analysis with an inductive approach. Results: Meta-themes included (a) the Latinx experience with culture, immigrant status, and structural barriers; and (b) being a super caregiver: being everything to everyone. Additional main themes were identified including family well-being, occupational and financial well-being, social support dynamics, challenges and rewards of family caregiving, and coping strategies. Discussion: Clinical interventions for Latinx Millennial caregivers should address cultural background, value of family/community, and systemic barriers for care and support.
Mother’s Experiences in Caring for Children with Stunting in Rural Indonesia
Authors: Wiliyanarti Pipit Festi , Choliq Idham , Hasanah Uswatun , Lin Shu-Yuan 
Published: September 2024

Introduction: Stunting is a major health problem in Indonesia. The aim of this study is to explore the experiences of mothers who take care of stunted children in rural Pamekasan Madura, Indonesia. Methods: This research employed a phenomenological approach and conducted in-depth interviews with 11 mothers in rural Pamekasan Madura, Indonesia, using purposive sampling. Data collection took place from June to September 2023. Results: This study presents Madurese mothers’ experiences caring for their children with stunting through two themes and five sub-themes: (a) beliefs passed down for generations: strong ancestral influence on feeding behaviors, traditional food, and traditional health-seeking behavior; and (b) insufficient resources on nutrition: a lack of time and money to provide nutrition-rich food and a lack of nutrition information. Discussion: Cultural beliefs, a lack of nutrition education, and economic barriers contribute to stunting in children. Our findings guide the design of tailored interventions for preventing stunting in Indonesian families and global communities.
Toxicity or Prosociality?: Civic Value and Gaming Citizenship in Competitive Video Game Communities
Authors: Kim Jin , Ortiz Naishly 
Published: September 2024

Background Online multiplayer video games are characterized by competitiveness and collaboration: the former resonates with toxicity and the latter with civic values. While it is urgent to consider efficient ways to cope with toxicity, it is worth interrogating how gamers shift between toxic competitiveness and gaming citizenship. Aim Drawing on feminist game studies, gaming citizenship, and ludic ethics approaches, this study examined how gamers embrace and resist toxic behaviors simultaneously in community contexts. Method We conducted in-depth interviews with twenty-two Overwatch players from June 2021 to May 2023 to elaborate the players experiences of toxic behaviors, their coping mechanisms, and the roles of gaming communities. Purposive and snowball samplings were used to recruit participants who regularly played competitive modes in Overwatch. Results From the interviews, two types of toxicity (tolerable, intolerable) were identified. Of the anti-toxic measures, ignoring was addressed as a common but problematic measure, while intervention as most effective measure. Gamers’ involvement in communities was discussed within three common frameworks: prosociality, gamer education, and gamer transformation. Overall, the interviewees showed ambivalence toward usage of anti-toxic measures. With limitations, we found that game communities can serve a venue for gaming citizenship to provide institutional supports for gamers. Conclusion This study contributes to scholarship on gaming toxicity and gaming citizenship. Our study illustrated that gaming communities are battlegrounds between prosociality and toxicity. We do not see vilification of toxicity as a panacea for toxic gaming problems. In that sense, gaming citizenship discourses helps to rekindle debate about stigmatized assumptions about toxicity.
Plantar Fascia Thickness and Stiffness in Healthy Individuals vs Patients With Plantar Fasciitis
Authors: Thanwisate Tanwarat , Siriwanarangsun Palanan , Piyaselakul Sitha , Tharmviboonsri Theerawoot , Chuckpaiwong Bavornrit 
Published: September 2024

Background: Plantar fasciitis is a major cause of heel pain, resulting from repetitive trauma to the plantar fascia and leading to structural changes within the fascia. It has been observed that plantar fascia thickness in plantar fasciitis patients exceeds that of normal individuals. However, the biomechanical properties of the plantar fascia in patients with plantar fasciitis remain unclear. Therefore, this study aimed to compare plantar fascia stiffness between healthy individuals and patients with plantar fasciitis across different areas. Methods: Fifty-eight participants were divided into 2 groups: 29 healthy individuals and 29 individuals with plantar fasciitis. B-mode ultrasonography was used to assess plantar fascia thickness, whereas shear wave elastography was employed to measure plantar fascia stiffness. The study focused on 3 distinct areas: calcaneal insertion, 1-cm distal area, and 2-cm distal area. Additionally, the most painful area reported by patients was marked in the plantar fasciitis group. Results: The findings showed that the plantar fasciitis group exhibited significantly greater plantar fascia stiffness in almost all areas compared to the healthy group ( P < .05). Moreover, the stiffness of the plantar fascia in the most painful area demonstrated the highest value compared with other areas within the plantar fasciitis group ( P < .05). Conclusion: This study suggests structural and mechanical changes in the plantar fascia in patients with plantar fasciitis.
Integrating of LMIs with Buckingham Π theorem for control of uncertain oscillating systems
Authors: Palizvan Zand Javad , Katebi Javad , Zhang Chunwei 
Published: September 2024

This paper introduces a novel framework for robust controller synthesis in oscillating systems by synergistically combining generalized linear matrix inequalities (GLMIs) with the Buckingham Π theorem. The primary goal is to enhance the design of robust controllers for systems with uncertain parameters through the exploitation of dimensionless groups derived from the Buckingham Π theorem. By establishing a dimensionless state-space representation, the proposed approach demonstrates adaptability to a broad spectrum of similar systems. The LMI-based formulation facilitates the systematic design of controllers capable of effectively mitigating the impact of parametric uncertainties. Simulation results for an uncertain inverted pendulum and a vehicle active suspension system validate the superior performance of the proposed method compared to conventional control techniques, such as MPC, LQG, SMC, PID, and LQR. For the uncertain inverted pendulum system, the proposed robust control scheme achieves a cart position stabilization in 5.35 s and pendulum stabilization in 6.3 s, which is faster than standard control algorithms. In the context of the vehicle active suspension system, the performance indices for sprung mass acceleration, suspension deflection, and tire deflection are 0.19, 0.47, and 0.07, respectively. These values indicate significant reductions when compared to conventional passive suspension systems and standard robust control methodologies.
Letrozole-induced reversible acute heart failure
Authors: Sekmek Serhat , Bayram Dogan , Seven Ismet , Perkin Perihan , Bal Oznur , Algin Efnan 
Published: September 2024

Introduction Letrozole is an aromatase inhibitor (AI), which suppresses plasma estrogen levels by inhibiting the aromatase enzyme, that causes the conversion of androgens to estrogen in peripheral tissues. There is very few information in the literature regarding the development of acute heart failure after AI use. We would like to report a case of a patient who was started letrozole for hormonal treatment and developed acute heart failure due to this. Case report Fifty-seven-year-old woman with hormone positive breast cancer was operated after neoadjuvant chemotherapy and received radiotherapy. Letrozole treatment was initiated after radiotherapy and the patient presented to the emergency department after two weeks with cough and dyspnea. Ejection fraction decreased to 20% and acute heart failure developed. Management and outcome Letrozole treatment was stopped. Afterwards, improvement in the patient's cardiac functions was observed. Letrozole-induced heart failure was thought to be reversible. Discussion Letrozole is one of the most commonly used HT in the treatment of hormone positive breast cancer. It may rarely cause cardiac side effects. It is very important to make patients aware of these issues and to be consulted by cardiology in case of possible cardiac symptoms.
A Comparison of Passive Rewarming Systems Following Cold Water Immersion
Authors: Wallace Phillip J. , Hodgkinson Matthew L. , Ramagnano Lucas , Janjuha Ramneek Singh , Andrade Mariska J. , Cheung Stephen S. 
Published: September 2024

Introduction We studied field rewarming using a typical winter sleeping bag versus two heated hypothermia wrap systems in a semi-realistic lab simulation. Methods 10 participants (8 M, 2 F) were cooled to 36.1°C core temperature through 10.5-11.5°C water immersion, then performed 60 min of passive rewarming in 0°C air. The rewarming methods tested were: 1) a −9°C rated mummy-style Sleeping Bag; 2) Doctor Down Rescue Wrap; and 3) Thermal Yielding Vascular Airway Capsule (TYVAC) system; the latter two methods included vapor barriers and two heating pads. Rectal and skin temperatures, along with metabolic heat production calculated via indirect calorimetry, were measured throughout rewarming. Results One male participant was removed from analysis due to lack of sufficient cooling. Rectal temperature decreased in the remaining participants by ∼1.1–1.2°C to 36.1°C during the initial immersion phase. Over the 60 min of rewarming, rectal temperature changes were Δ0.0 ± 0.6°C in a sleeping bag, Δ+0.2 ± 0.3°C in Doctor Down, and Δ+0.2 ± 0.3°C in TYVAC, with no significant differences across methods. Mean skin temperatures, metabolic heat production, and perceptual measures were also similar across methods with no method×time interactions. Conclusions After 60 min of passive rewarming in cold conditions, all three rewarming methods were able to stall continued core cooling to levels at or slightly above post-immersion temperatures. With no differences in any physiological measures, it appears that all three rewarming methods are equally viable options for wilderness responders, and the choice should come down to environmetal conditions, availability, convenience, and ergonomics rather than rewarming efficacy.
In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment
Authors: Radha MJ , Basha Mahaboob P. 
Published: September 2024

Neuroendocrine regulation is disrupted by di-n-butyl phthalate (DBP) when exposure occurs during the critical periods of fetal development, which can lead to neurological disorders. To evaluate the toxic potential of DBP, it is necessary to conduct teratological studies, which could determine impacts on the development of the fetus. The present study was designed to understand the sequelae of neuroendocrine regulation in one-month-old pups when rats were exposed to DBP (F1–F3) in utero and during lactation. The rats received DBP (500 mg/kg BW/day) dissolved in olive oil through oral gavage from gestation day 6 to postnatal day 30, while the control group received the olive oil (vehicle) during the same timeline. Following the exposure, thyroid profile and estradiol, which were measured at GD-19, exhibited a significant decrease ( P < 0.05) in dams (F0–F2). The exposure resulted in developmental outcomes, including underdeveloped fetuses, and a notable number of resorptions in experimental rats. The one-month-old pups were assessed for serum thyroid profile and testosterone and neurotransmitters in discrete brain regions, cerebral cortex, cerebellum, and hippocampus for up to three generations. The levels of dopamine and cortisol showed a significant increase ( P < 0.05), but serotonin levels decreased when examined in distinct brain regions of the experimental group as compared to the control. DBP, which is considered an endocrine disruptor, had the most impact on the third generation in this study, leading to a significant decrease in testosterone levels. In summary, in utero exposure to DBP impaired the neuroendocrine system and had an antiandrogenic effect in the three successive generations.
Immune-Related Long Non-Coding RNA Signature Determines Prognosis and Immunotherapeutic Coherence in Esophageal Cancer
Authors: Uttam Vivek , Kapoor Harmanpreet Singh , Rana Manjit Kaur , Yadav Ritu , Prakash Hridayesh , Jain Manju , Tuli Hardeep Singh , Jain Aklank 
Published: September 2024

Objectives: Aim of this study was to explore the immune-related lncRNAs having prognostic role and establishing risk score model for better prognosis and immunotherapeutic coherence for esophageal cancer (EC) patients. Methods: To determine the role of immune-related lncRNAs in EC, we analyzed the RNA-seq expression data of 162 EC patients and 11 non-cancerous individuals and their clinically relevant information from the cancer genome atlas (TCGA) database. Bioinformatic and statistical analysis such as Differential expression analysis, co-expression analysis, Kaplan Meier survival analysis, Cox proportional hazards model, ROC analysis of risk model was employed. Results: Utilizing a cutoff criterion (log2FC > 1 + log2FC < −1 and FDR < 0.01), we identified 3737 RNAs were significantly differentially expressed in EC patients. Among these, 2222 genes were classified as significantly differentially expressed mRNAs (demRNAs), and 966 were significantly differentially expressed lncRNAs (delncRNA). Through Pearson correlation analysis between differentially expressed lncRNAs and immune related-mRNAs, we identified 12 immune-related lncRNAs as prognostic signatures for EC. Notably, through Kaplan-Meier analysis on these lncRNAs, we found the low-risk group patients showed significantly improved survival compared to the high-risk group. Moreover, this prognostic signature has consistent performance across training, testing and entire validation cohort sets. Using ESTIMATE and CIBERSORT algorithm we further observed significant enriched infiltration of naive B cells, regulatory T cells resting CD4+ memory T cells, and, plasma cells in the low-risk group compared to high-risk EC patients group. On the contrary, tumor-associated M2 macrophages were highly enriched in high-risk patients. Additionally, we confirmed immune-related biological functions and pathways such as inflammatory, cytokines, chemokines response and natural killer cell-mediated cytotoxicity, toll-like receptor signaling pathways, JAK-STAT signaling pathways, chemokine signaling pathways significantly associated with identified IRlncRNA signature and their co-expressed immune genes. Furthermore, we assessed the predictive potential of the lncRNA signature in immune checkpoint inhibitors; we found that programed cell death ligand 1 (PD-L1; P-value = .048), programed cell death ligand 2 (PD-L2; P-value = .002), and T cell immunoglobulin and mucin-domain containing-3 (TIM-3; P-value = .045) expression levels were significantly higher in low-risk patients compared to high-risk patients. Conclusion: We believe this study will contribute to better prognosis prediction and targeted treatment of EC in the future.
The Influencing Factors of Psychosocial Adaptation of Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Zhu Hanjing , Yang Linning , Yin Hongfan , Yuan Xia , Gu Jia , Yang Yan 
Published: September 2024

Purpose: The psycho-social adaptation of cancer patients is very important, which affects the treatment, rehabilitation process and prognosis of patients, and is closely related to the subjective well-being and quality of life of patients. However, the key factors affecting the psycho-social adjustment of cancer patients are not clear yet. This study aims to evaluate the psycho-social adaptation of cancer patients and its influencing factors based on a meta-analysis. Basic procedures: The Systematic review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist and guided by the society-to-cell model framework. Literature retrieval was conducted from the construction of the library to December 2023. Main findings: Fourteen pieces of literature were included in this study, with a total sample size of 2922 cases. Among the 14 literatures included, 9 were in English and 5 were in Chinese, published between 1991 and 2021. All of the 14 literatures were cross-sectional studies. According to the society-to-cells model framework, the influencing factors are divided into 5 levels: society, community, family, individual, and physiology. However, studies related to the cellular level are lacking. Principal conclusions: The psychosocial adaptation of cancer patients is affected by physiology, individual, family, community and society, among which age, education level, disease uncertainty, hope level, psychological pain, self-efficacy, social support, coping styles (facing, avoidance, submission, and emotion-oriented) are the main factors affecting the psychosocial adaptation of cancer patients. However, studies related to the cellular level are lacking. This may be due to the fact that most of the factors from the individual to the society level are intervenable, and most studies focus more on the mining of these levels of factors. However, the biological basis is crucial to the occurrence and development of diseases, and needs to be paid attention to by nursing staff, and further research on this level needs to be strengthened in the future.
Dietary and Lifestyle Insulinemic Potential Indices and Risk Factors of Metabolic Syndrome Among Overweight and Obese Individuals: A Cross-Sectional Study
Authors: Hojati Ali , Abbasalizad Farhangi Mahdieh 
Published: September 2024

Background: As a worldwide pandemic, metabolic syndrome (MetS) is related with high disease burden. The emergence of multiple chronic diseases can be attributed to unfavorable dietary and lifestyle choices made by individuals, with hyperinsulinemia and insulin resistance as the underlying causes. Current study sought to assess the relationship between the Empirical Dietary Index for Hyperinsulinemia (EDIH) and the Empirical Lifestyle Index for Hyperinsulinemia (ELIH) and MetS risk factors. Methods: This cross-sectional study involved 339 individuals between the ages of 20 and 50, who were either obese or overweight, and were recruited from Tabriz, Iran. In this study, a validated semi-quantitative Food Frequency Questionnaire (FFQ) with 168 questions was used to assess individuals’ food consumption. Blood tests were performed to assess total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, as well as blood glucose and insulin levels. Results: After multivariable adjustment, among tertiles of EDIH, systolic blood pressure (SBP) and TG were significantly different. Also, SBP, diastolic blood pressure (DBP), and HDL-C significantly differed across tertiles of ELIH. In multivariate-adjusted models, individuals classified in the highest tertile of EDIH demonstrated elevated ORs in relation to FBG levels [OR: 1.035 (1.004-1.068; P < .05)], and the second tertile of ELIH was inversely associated with SBP [OR: 0.966 (0.935-0.999; P < .05)], DBP [OR: 0.972 (0.948-0.997; P < .05)], TG in the model I [OR: 0.991 (0.983-0.999; P < .05)], and model II [OR: 0.991 (0.983-0.999; P < .05)]. Conclusion: Considering the findings of our study, higher insulinemic dietary potential, indicated by EDIH, can be related to higher odds of FBG and decreased odds of TG as risk factors of MetS. Furthermore, our findings suggest that individuals with a higher ELIH may potentially exhibit lower SBP and DBP levels. Nevertheless, further experimental and long-term investigations are necessary to fully comprehend this association.