bluuebunny/crossref_metadata_2025_split huggingface dataset:
Median Sacral Artery, Sympathetic Nerves, and the Coccygeal Body: A Study Using Serial Sections of Human Embryos and Fetuses
Authors: Jin Zhe Wu , Cho Kwang Ho , Jang Hyung Suk , Murakami Gen , Rodríguez‐Vázquez Jose Francisco 
Published: May 2016

ABSTRACTTo examine how the median sacral artery (MSA) is involved with the coccygeal body or glomus coccygeum, we studied serial frontal or sagittal sections of 14 embryos (approximately 5–6 weeks of gestation) and 12 fetuses (10–18 weeks). At five weeks, the caudal end of the dorsal aorta (i.e., MSA) accompanied putative sympathetic ganglion cells in front of the upper coccygeal and lower sacral vertebrae. At six weeks, a candidate for the initial coccygeal body was identified as a longitudinal arterial plexus involving nerve fibers and sympathetic ganglion cells between arteries. At 10–18 weeks, the MSA exhibited a highly tortuous course at the lower sacral and coccygeal levels, and was attached to and surrounded by veins, nerve fibers, and sympathetic ganglion cells near and between the bilateral origins of the levator ani muscle. Immunohistochemistry demonstrated expression of tyrosine hydroxylase and chromogranin A in the nerves. However, throughout the stages examined, we found no evidence suggestive of an arteriovenous anastomosis, such as well‐developed smooth muscle. An acute anterior flexure of the vertebrae at the lower sacrum, as well as regression of the secondary neural tube, seemed to induce arterial plexus formation from an initial straight MSA. Nerves and ganglion cells were likely to be secondarily involved with the plexus because of the close topographical relationship. However, these nerves might play a major role in the extreme change into adult morphology. An arteriovenous anastomosis along the MSA might be an overinterpretation, at least in the prenatal human. Anat Rec, 299:819–827, 2016. © 2016 Wiley Periodicals, Inc.
Genetic variation and cognitive dysfunction in opioid‐treated patients with cancer
Authors: Kurita Geana Paula , Ekholm Ola , Kaasa Stein , Klepstad Pål , Skorpen Frank , Sjøgren Per 
Published: May 2016

AbstractBackground and purposeThe effects of single‐nucleotide polymorphisms (SNPs) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but they could potentially be related to poor functioning. This study aimed at identifying associations between SNPs of candidate genes, high opioid dose, and cognitive dysfunction.MethodsCross‐sectional multicenter study (European Pharmacogenetic Opioid Study, 2005–2008); 1586 patients; 113 SNPs from 41 genes. Inclusion criteria: cancer, age ≥18 year, opioid treatment, and available genetic data. Cognitive assessment by Mini‐Mental State Examination (MMSE). Analyses: SNPs were rejected if violation of Hardy–Weinberg equilibrium (P < 0.0005), or minor allele frequency <5%; patients were randomly divided into discovery sample (2/3 for screening) and validation sample (1/3 for confirmatory test); false discovery rate of 10% for determining associations (Benjamini–Hochberg method). Co‐dominant, dominant, and recessive models were analyzed by Kruskal–Wallis and Mann–Whitney tests.ResultsIn the co‐dominant model significant associations (P < 0.05) between MMSE scores and SNPs in the HTR3E, TACR1, and IL6 were observed in the discovery sample, but the replication in the validation sample did not confirm it. Associations between MMSE scores among patients receiving ≥400 mg morphine equivalent dose/day and SNPs in TNFRSF1B, TLR5, HTR2A, and ADRA2A were observed, but they could not be confirmed in the validation sample. After correction for multiple testing, no SNPs were significant in the discovery sample. Dominant and recessive models also did not confirm significant associations.ConclusionsThe findings did not support influence of those SNPs analyzed to explain cognitive dysfunction in opioid‐treated patients with cancer.
An efficient GPU out‐of‐core framework for interactive rendering of large‐scale CAD models
Authors: Xue Junjie , Zhao Gang , Xiao Wenlei 
Published: May 2016

AbstractReal‐time rendering of large‐scale engineering computer‐aided design (CAD) models has been recognized as a challenging task. Because of the constraints of limited graphics processing unit (GPU) memory size and computation capacity, a massive model with hundreds of millions of triangles cannot be loaded and rendered in real‐time using most of modern GPUs. In this paper, an efficient GPU out‐of‐core framework is proposed for interactively visualizing large‐scale CAD models. To improve efficiency of data fetching from CPU host memory to GPU device memory, a parallel offline geometry compression scheme is introduced to minimize the storage cost of each primitive by compressing the levels of detail (LOD) geometries into a highly compact format. At the rendering stage, occlusion culling and LOD processing algorithms are integrated and implemented with an efficient GPU‐based approach to determine a minimal scale of primitives to be transferred for each frame. A prototype software system is developed to preprocess and render massive CAD models with the proposed framework. Experimental results show that users can walkthrough massive CAD models with hundreds of millions of triangles at high frame rates using our framework. Copyright © 2016 John Wiley & Sons, Ltd.
Chemical Composition of Ballota macedonica Vandas and Ballota nigra L. ssp. foetida (Vis.) Hayek Essential Oils – The Chemotaxonomic Approach
Authors: Đorđević Aleksandra S. , Jovanović Olga P. , Zlatković Bojan K. , Stojanović Gordana S. 
Published: May 2016

The essential oils isolated from fresh aerial parts of Ballota macedonica (two populations) and Ballota nigra ssp. foetida were analyzed by GC and GC/MS. Eighty five components were identified in total; 60 components in B. macedonica oil (population from the Former Yugoslav Republic of Macedonia), 34 components in B. macedonica oil (population from the Republic of Serbia), and 33 components in the oil of B. nigra ssp. foetida accounting for 93.9%, 98.4%, and 95.8% of the total oils, respectively. The most abundant components in B. macedonica oils were carotol (13.7 – 52.1%), germacrene D (8.6 – 24.6%), and (E)‐caryophyllene (6.5 – 16.5%), while B. nigra ssp. foetida oil was dominated by (E)‐phytol (56.9%), germacrene D (10.0%), and (E)‐caryophyllene (4.7%). Multivariate statistical analyses (agglomerative hierarchical cluster analysis and principal component analysis) were used to compare and discuss relationships among Ballota species examined so far based on their volatile profiles. The chemical compositions of B. macedonica essential oils are reported for the first time.
Transcatheter native pulmonary valve and tricuspid valve replacement with the sapien XT: Initial experience and development of a new delivery platform
Authors: Levi Daniel S. , Sinha Sanjay , Salem Morris M. , Aboulhosn Jamil A. 
Published: May 2016

BackgroundWhile the Melody valve is unable to be used for replacement of large pulmonary outflow tracts, the 29 mm Sapien XT transcatheter valve, designed specifically for aortic valve replacement, can potentially be used in these large native outflow tracts. Techniques to enable off‐label use of the Sapien XT valve for large‐diameter pulmonary and tricuspid valve replacement are described.MethodsUse of the Sapien valve for transcatheter pulmonary and tricuspid valve replacement using both the commercially available Novaflex+ system and using a novel flexible delivery system was reviewed. This customized flexible delivery platform was constructed using the Ensemble sheath and a 30 mm Nucleus balloon. This system was bench tested prior to its clinical use.ResultsTen patients had successful implantation of Sapien valves into native right ventricular outflow tracts (RVOTs) (n = 7) or tricuspid valves (n = 3). There was no stenosis or regurgitation after Sapien valve implantation. Several of the pulmonary valve replacement cases were extremely challenging due to the limited flexibility of the Novaflex system. The Sapien valve was crimped onto a 30 mm Nucleus balloon preloaded through an Ensemble sheath. This system was able to consistently deliver the Sapien valve safely in a bench model as well as in native RVOTs in two patients.ConclusionThe 29 mm Sapien XT valve allows for large‐diameter transcatheter valve replacement in both the pulmonary and tricuspid positions. Initial results of new techniques to utilize a more flexible delivery platform are described that could obviate the need for the Novaflex system. © 2016 Wiley Periodicals, Inc.
Preliminary effects of renal denervation with saline irrigated catheter on cardiac systolic function in patients with heart failure: A prospective, randomized, controlled, pilot study
Authors: Chen Weijie , Ling Zhiyu , Xu Yanping , Liu Zengzhang , Su Li , Du Huaan , Xiao Peilin , Lan Xianbin , Shan Qijun , Yin Yuehui 
Published: May 2016

ObjectiveTo assess efficacy and safety of renal denervation (RDN) for heart failure (HF).BackgroundRDN has been demonstrated to be an effective method in lowing overactive sympathetic nerve. However, it's feasibility and efficacy for HF is unclear.MethodsIn this randomized, controlled pilot study, patients with HF were randomly assigned in 1:1 ratio to undergo RDN plus optimal medical therapy (RDN group) or only optimal medical therapy (control group). Before randomization, patients received optimal medical therapy at least half a year. Primary efficacy end point was the change in LVEF over six months; secondary efficacy end points were the change in six‐minute walk distance and SF‐36 Health Survey scores over six months.ResultsUp to Apr 2015, sixty symptomatic HF patients were successfully enrolled into study. Thirty patients were randomly assigned to RDN group and 30 patients were randomly assigned to control group. All patients completed six months follow up. During follow up, no severe adverse events were observed. Blood pressure was stable in both groups. Patients in RDN group had shown a significant improvement in LVEF (P < 0.001), SMWD (P = 0.043), NYHA class (P < 0.001), NT‐proBNP (P < 0.001) and office heart rate (P = 0.008). Compared with control group, RDN patients were associated with significant improvement in all domains of SF‐36 but bodily pain (P = 0.74). No significant change in estimate glomerular filtration nor complication of renal artery stenosis were observed.ConclusionsResults imply that RDN could be safely applied to treatment of HF and probably improve cardiac systolic function and patients' quality of life. © 2016 Wiley Periodicals, Inc.
Risk factors and outcomes in patients with ectatic infarct‐related artery who underwent primary percutaneous coronary intervention after ST elevated myocardial infarction
Authors: Ipek Gokturk , Gungor Baris , Karatas Mehmet Baran , Onuk Tolga , Keskin Muhammed , Tanik Ozan , Hayiroglu Mert Ilker , Oz Ahmet , Borklu Edibe Betul , Bolca Osman 
Published: May 2016

ObjectiveWe aimed to assess the risk factors for coronary artery ectasia (CAE) as infarct‐related artery (IRA) and short‐term and 1 year outcomes.BackgroundsCAE in patients with ST elevated myocardial infarction (STEMI) is a rare condition with a limited knowledge about the risk factors associated with coronary artery ectasia in STEMI and prognosis after primary percutaneous coronary interventions.MethodsRetrospectively, 1655 patients with STEMI who were undergone coronary angiography were included in this study. Patients were divided into two groups according to their coronary anatomy as ectasia and control groups. Demographic features, angiographic results, and clinical events were compared. Multivariate analysis was performed to assess the association of the features with CAE in STEMI.ResultsIn total, 1655 patients (99 patients in CAE group vs 1556 patients in control group) were analyzed. Hypertension and smoking were significantly higher in CAE group. No‐reflow rates were significantly higher (13.1% vs 5.4%, p = 0.004) in CAE group. In‐hospital mortality rates were similar between the groups. Difference in revascularization rates (8.1% vs 9.6%, p = 0.39) and death in 1 year (6.1% vs 4.9%, p = 0.37) were also nonsignificant between the groups. According to results of the multivariate analysis, hypertension (Odds ratio (OR): 1.71 (1.14–2.58), p = 0.01) and smoking (OR: 1.98 (1.32–2.99), p = 0.001) remained significantly associated with coronary ectasia.ConclusionIn conclusion, despite being higher no‐reflow rates, short‐term and 1 year survival and revascularization rates were similar between the groups. Additionally, hypertension and smoking were associated with CAE as IRA. © 2016 Wiley Periodicals, Inc.
Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation
Authors: Seiffert Moritz , Conradi Lenard , Gutwein Andreas , Schön Gerhard , Deuschl Florian , Schofer Niklas , Becker Nina , Schirmer Johannes , Reichenspurner Hermann , Blankenberg Stefan , Treede Hendrik , Schäfer Ulrich 
Published: May 2016

BackgroundAnemia is linked to impaired outcome in patients with cardiovascular diseases. We sought to characterize the impact of baseline anemia on mid‐term outcome after transcatheter aortic valve implantation (TAVI).Methods and resultsData of 1201 consecutive TAVI patients were retrospectively analyzed. Baseline anemia was defined according to the WHO (hemoglobin <12g/dl [female], <13g/dl [male]). It was prevalent in 59.0% of patients and associated with a higher preoperative risk (STS‐PROM 7.8 ± 5.7 vs. 6.2 ± 4.1%, P < 0.001). Survival was similar at 30 days (90.5 vs. 91.2%, P = 0.626) but NYHA functional capacity was impaired in patients with baseline anemia (classes III/IV: 20.6 vs. 15.6%, P = 0.006). Low baseline hemoglobin (OR 0.85, CI 0.73–0.98, P = 0.025), blood transfusion (OR 2.42, CI 1.38–4.28, P = 0.002), and bleeding complications (OR 2.21, CI 1.27‐3.81, P = 0.005) were in addition associated with acute kidney injury after TAVI. Three‐year survival was reduced (49.6 vs. 64.9%, P = 0.002) and baseline anemia was linked to increased mid‐term mortality (HR 1.43, CI 1.13–1.82, P = 0.003), however its effect was surpassed by the adverse impact of periprocedural complications. Conclusions: Baseline anemia was associated with increased morbidity and mortality after TAVI. Preprocedural hemoglobin levels need to be assessed for risk stratification and blood conservation management seems essential. As a potentially modifiable target, the role of pretreatment of anemia prior to TAVI remains to be determined. © 2016 Wiley Periodicals, Inc.
Bioresorbable vascular scaffold thrombosis in a consecutive cohort of 550 patients
Authors: Tröbs Monique , Achenbach Stephan , Röther Jens , Klinghammer Lutz , Schlundt Christian 
Published: May 2016

ObjectiveTo determine the rate of bioresorbable vascular scaffold (BVS) thrombosis in a large, real‐world population.BackgroundThere is some concern about device thrombosis after percutaneous coronary intervention (PCI) using BVS. No data have been published for PCI using both BVS and metal stents.MethodsA cohort of 550 consecutive patients who underwent PCI for stable chest pain or acute coronary syndromes with implantation of at least one BVS (Absorb, Abbott Vascular) was systematically followed up by telephone interview and review of medical charts. Data on device thrombosis were retrospectively analyzed in relationship to clinical and angiographic characteristics.ResultsFollow‐up was achieved in 533 patients (97%, median follow‐up 233 days). A total of 964 BVS were implanted in 645 vessels. In addition, 234 metal stents were implanted in 149 patients, including “hybrid intervention” with the combined use of BVS and stents in the same artery in 122 patients. Documented were 15 definite, 1 probable, and 8 possible cases of device thrombosis (rate of definite/probable device thrombosis: 3.0%). Of these, 6 definite and 6 possible thromboses could be unambiguously attributed to BVS (1.1%), whereas a total of 11 definite, 1 probable, and 8 possible thromboses were potentially attributable to BVS (2.3%). Definite device thrombosis occurred in 7/122 patients with “hybrid intervention” (5.7%).ConclusionsIn a large real‐world cohort treated with BVS, the rate of scaffold thrombosis was higher than published for randomized trials. A high rate of thrombosis was observed after combined implantation of BVS and stents within one vessel. © 2016 Wiley Periodicals, Inc.
Thermodynamics of Hydrogen Production Based on Coal Gasification Integrated with a Dual Chemical Looping Process
Authors: Zhu Lin , Li Luling , Zhang Zheng , Chen Hu , Zhang Le , Wang Feng 
Published: May 2016

AbstractThe performance of an innovative hydrogen production technology, which is based on a coal gasification system integrated with a dual chemical looping process, namely, chemical looping air separation (CLAS) and calcium looping CO2 absorption (CaL), is evaluated. CLAS offers an advantage over other mature technologies in that it can reduce capital costs considerably. CaL is an efficient method for hydrogen production and CO2 capturing. The proposed technologies are studied by Aspen Plus based on the Gibbs free energy minimization principle. The key factors in terms of reduction temperature, gasification pressure, temperature of water‐gas shift reaction, and water consumption, which proved to have a significant impact on the performance of the whole hydrogen generation process, are discussed.
Pd–Porphyrin Oligomers Sensitized for Green‐to‐Blue Photon Upconversion: The More the Better?
Authors: Xun Zhiqing , Zeng Yi , Chen Jinping , Yu Tianjun , Zhang Xiaohui , Yang Guoqiang , Li Yi 
Published: May 2016

AbstractA series of directly meso‐meso‐linked Pd–porphyrin oligomers (PdDTP‐M, PdDTP‐D, and PdDTP‐T) have been prepared. The absorption region and the light‐harvesting ability of the Pd–porphyrin oligomers are broadened and enhanced by increasing the number of Pd–porphyrin units. Triplet–triplet annihilation upconversion (TTA‐UC) systems were constructed by utilizing the Pd–porphyrin oligomers as the sensitizer and 9,10‐diphenylanthracene (DPA) as the acceptor in deaerated toluene and green‐to‐blue photon upconversion was observed upon excitation with a 532 nm laser. The triplet–triplet annihilation upconversion quantum efficiencies were found to be 6.2 %, 10.5 %, and 1.6 % for the [PdDTP‐M]/DPA, [PdDTP‐D]/DPA, and [PdDTP‐T]/DPA systems, respectively, under an excitation power density of 500 mW cm−2. The photophysical processes of the TTA‐UC systems have been investigated in detail. The higher triplet–triplet annihilation upconversion quantum efficiency observed in the [PdDTP‐D]/DPA system can be rationalized by the enhanced light‐harvesting ability of PdDTP‐D at 532 nm. Under the same experimental conditions, the [PdDTP‐D]/DPA system produces more 3DPA* than the other two TTA‐UC systems, benefiting the triplet–triplet annihilation process. This work provides a useful way to develop efficient TTA‐UC systems with broad spectral response by using Pd–porphyrin oligomers as sensitizers.
Generation of Benzyne Species from Diphenylphosphoryl Derivatives: Simultaneous Exchange of Three Functional Groups
Authors: Gorobets Evgueni , Parvez Masood , Derksen Darren J. , Keay Brian A. 
Published: May 2016

AbstractInteraction of (2‐diphenylphosphoryl‐3‐iodo‐4‐methoxy‐phenyl) methanol with NaH in DMF at ambient temperature results in the generation of benzyne intermediates that can be trapped by furan or DMF. Trapping with DMF forms 3‐(dimethylaminomethyl)‐2‐hydroxy‐6‐methoxybenzaldehyde demonstrating the simultaneous exchange of three functionalities in a single step. The presence of the alkoxy substituent adjacent to iodine is critical for high regioselectivity addition of DMF. The corresponding bromide or triflate can be used in place of the iodide with equal efficiency. This methodology was used to synthesize the reported structure of gigasol and leading to a structural reassignment of this biscoumarin natural product.
Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6‐Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence
Authors: Tong Shuo , Wang Qian , Wang Mei‐Xiang , Zhu Jieping 
Published: May 2016

AbstractIsonitrile 1 due to its carbene‐like reactivity serves generally as a one‐carbon synthon in a diverse set of organic transformations. We report in this article that the isocyano group can also act as a polarized triple bond to undergo, as a two‐atom synthon, heteroannulation with primary propargylamines 15. In addition, we serendipitously discovered that the reaction pathways can be modulated by simply changing the catalyst loading. In the presence of 0.1 equiv of Yb(OTf)3 or TfOH, the reaction between 1 and 15 afforded exclusively imidazoles 16 by a formal [3+2] cycloaddition. At a higher catalyst loading (Yb(OTf)3 (0.4 equiv) or TfOH (0.5 equiv)) under otherwise identical conditions, the same reaction furnished 1,6‐dihydropyrimidines 17 in good to excellent yields by way of a formal [4+2] cycloaddition process. Mechanistic investigations indicated that both annulations went through an amidine intermediate resulting from the insertion of the isocyano group to the NH bond of the primary amine. Subsequent catalyst‐loading‐dependent 5‐exo‐dig or 6‐endo‐dig cyclization provided selectively the two heterocycles, respectively.
ChemInform Abstract: CRYSTAL STRUCTURE OF THE MAGNESIUM OCTACHLOROTRIMERCURATE(II) HEXAHYDRATE (MGHG3CL8.6H2O)
Authors: BRODERSEN K. , PEZZEI G. , THIELE G. 
Published: May 2016

AbstractDie durch Kristallisation aus wäßrigen Lösungen von MgCl2 und HgCl, in Form farbloser Kristalle dargestellte Titelverbindung (für die Existenz von MgHgCLy 6 H2O un‐d Mg?gzClg 6 H2O wird kein Hinweis gefunden) kristallisiert in der Raumgruppe Pl mit Z=1.
ChemInform Abstract: GAMMA RADIATION EFFECTS ON THE STRENGTH OF A BOROSILICATE GLASS
Authors: ZDANIEWSKI W. A. , EASLER T. E. , BRADT R. C. 
Published: May 2016

AbstractBez. der Beseitigung von radioaktiven Abfallen durch Inkorporation in Borosilicat‐Glas wurde der Einfluß von "Co‐y‐Strahlung bis zu l0" rad untersucht.
ChemInform Abstract: ELECTROCHEMISTRY OF THE TRINUCLEAR AQUA MO3IV AND MO3III IONS IN ACIDIC MEDIA
Authors: PAFFETT M. T. , ANSON F. C. 
Published: May 2016

AbstractDie Messungen (cyclische Voltammogramme, Polarogramme, ESR‐Spektren) zeigten, daß die Mo(IV)3 enthaltenden dreikernigen Ionen Mo3O4(H,O)3 und das Oxalatoderivat Mo3O4(C,O4)3(H,O)3 ′ in sauren Medien reversibel zu dreikernigen Mo(III)‐ Spezies reduziert werden können.
ChemInform Abstract: DYNAMICS OF THE CHEMILUMINESCENT OXIDATION OF ZINC ATOMS BY NITROUS OXIDE
Authors: WICKE B. G. 
Published: May 2016

AbstractDie Dynamik von A wurde in einer neuen Molekularstrahl‐Apparatur aus Quellenkammer (Laser‐Verdampfung von einem Zn‐Film‐Target), Reaktionskammer (mit N2O‐ Gas und Photomultiplier) und Detektorkammer (mit Quadrupol‐Massenspektrometer) untersucht.
ChemInform Abstract: SYMMETRY OF THE INTERMEDIATE IN THE HYDROXYLAMINE‐NITROUS ACID REACTION
Authors: BONNER F. T. , KADA J. , PHELAN K. G. 
Published: May 2016

AbstractMassenspektren des Produktes N2O bei ′sN‐Tracer‐Untersuchungen zur Reaktion A im Aciditätsbereich von 5 M HClO4 bis pH 9 ergaben, daß N2O aus einer symm. Vorläuferspezies resultiert (Diskussion zu den Primärprodukten ON‐NHOH und H3NONO sowie zur cis‐H,N,O2‐Zers.
ChemInform Abstract: REACTION OF URANIUM(V) AND URANIUM(VI) COMPOUNDS WITH THIONYL CHLORIDE
Authors: SAWODNY W. , REDIESS K. , THEWALT U. 
Published: May 2016

AbstractDie Reaktion von UO3, UO2Cl2, UCl6 oder UCl5 führt in jedem Fall zu UCl5·SCl2, [SCl3]+[UCl6]‐ oder einem Gemisch von beiden, während das früher vermutete UCl5·OSCl2 nicht entsteht.
ChemInform Abstract: AN EASY PREPARATION WITH FULL CHARACTERIZATION OF PD6CL12: A FORM OF PALLADIUM CHLORIDE SOLUBLE IN AROMATIC SOLVENTS
Authors: YATSIMIRSKI A. , UGO R. 
Published: May 2016

AbstractBei der gemäß Reaktion Asehr einfach darstellbaren Titelverbindung handelt es sich, wie die röntgenographische und spektroskopische (MS, UV‐VIS) Charakterisierung sowie die Molekulargewichtsbestimmung in Benzol zeigen, um die von Schäfer et al. 1967 als β‐PdClg bezeichnete Form.