bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Stability and Deformation of Solvated Sm@C2(42)-C90 under High Pressure
Authors: Cui Jinxing , Yao Mingguang , Yang Hua , Liu Ziyang , Liu Shijie , Du Mingrun , Li Quanjun , Liu Ran , Cui Tian , Liu Bingbing 
Published: August 2016

AbstractSolvated fullerenes recently have been shown to exhibit novel compression behaviors compared with the pristine fullerenes. However, less attention has been focused on the large cage endohedral metallofullerenes. Here, we have firstly synthesized solvated Sm@C90 microrods by a solution drop-drying method, and then studied the transformations under high pressure. The pressure-induced structural evolutions of Sm@C90 molecules both undergo deformation and collapse. The band gaps of both samples decrease with increasing pressure. The trapped Sm atom plays a role in restraining the compression of the adjacent bonds. The solvent plays a role in protecting Sm@C90 against collapse in the region of 12–20 GPa, decreasing and postponing the change of band gap. Above 30 GPa, the carbon cages collapse. Released from 45 GPa, the compressed solvated Sm@C90 forms a new ordered amorphous carbon cluster (OACC) structure with metal atoms trapped in the units of amorphous carbon clusters, which is different from the OACC structure formed by compressing solvated C60 and C70. This discovery opens the door for the creation of new carbon materials with desirable structural and physical properties when suitable starting materials are selected.
EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma
Authors: Han Chuangye , Liao Xiwen , Qin Wei , Yu Long , Liu Xiaoguang , Chen Gang , Liu Zhengtao , Lu Sicong , Chen Zhiwei , Su Hao , Zhu Guangzhi , Lu Zili , Liu Zhiming , Qin Xue , Gui Ying , Mo Zengnan , Li Lequn , Peng Tao 
Published: August 2016

AbstractThis study was to explore the association between gene variants and p21 expression and investigate the TP53-independent p21 regulation in hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) patients from Guangxi by genome-wide association study. 426 HBV-related HCC patients were enrolled. Results showed that, after quality control, a total of 21,643 SNPs were identified in 107 p21 positive and 298 p21 negative patients. The variants of epidermal growth factor receptor (EGFR; rs2227983 and rs6950826) and spectrin repeat containing, nuclear envelope 2 (SYNE2; rs8010699, rs4027405 and rs1890908) were associated with p21 expression. Moreover the haplotype block (rs2227983 and rs6950826, r2 = 0.378) in EGFR and the haplotype block in SYNE2 (rs8010699 was in strong LD with rs4027405 and rs1890908 (r2 = 0.91 and 0.70, respectively)) were identified and the haplotype A-G of EGFR and haplotype G-A-A of SYNE2 were significantly associated with p21 expression (P < 0.01). rs4027405 and rs1890908 were significantly associated with overall survival and patients with AG/GG genotypes of SYNE2 gene had a worse overall survival (P = 0.001, P = 0.002). Our findings indicate that variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related HCC in a TP53-indenpdent manner.
Metabolic and diffusional limitations of photosynthesis in fluctuating irradiance in Arabidopsis thaliana
Authors: Kaiser Elias , Morales Alejandro , Harbinson Jeremy , Heuvelink Ep , Prinzenberg Aina E. , Marcelis Leo F. M. 
Published: August 2016

AbstractA better understanding of the metabolic and diffusional limitations of photosynthesis in fluctuating irradiance can help identify targets for improving crop yields. We used different genotypes ofArabidopsis thalianato characterise the importance of Rubisco activase (Rca), stomatal conductance (gs), non-photochemical quenching of chlorophyll fluorescence (NPQ) and sucrose phosphate synthase (SPS) on photosynthesis in fluctuating irradiance. Leaf gas exchange and chlorophyll fluorescence were measured in leaves exposed to stepwise increases and decreases in irradiance.rwt43, which has a constitutively active Rubisco enzyme in different irradiance intensities (except in darkness), showed faster increases than the wildtype, Colombia-0, in photosynthesis rates after step increases in irradiance.rca-2, having decreased Rca concentration, showed lower rates of increase. Inaba2-1, high gsincreased the rate of change after stepwise irradiance increases, while in C24, low gstended to decrease it. Differences in rates of change between Colombia-0 and plants with low levels of NPQ (npq1-2,npq4-1) or SPS (spsa1) were negligible. In Colombia-0, the regulation of Rubisco activation and of gswere therefore limiting for photosynthesis in fluctuating irradiance, while levels of NPQ or SPS were not. This suggests Rca and gsas targets for improvement of photosynthesis of plants in fluctuating irradiance.
Soliton driven angiogenesis
Authors: Bonilla L. L. , Carretero M. , Terragni F. , Birnir B. 
Published: August 2016

AbstractAngiogenesis is a multiscale process by which blood vessels grow from existing ones and carry oxygen to distant organs. Angiogenesis is essential for normal organ growth and wounded tissue repair but it may also be induced by tumours to amplify their own growth. Mathematical and computational models contribute to understanding angiogenesis and developing anti-angiogenic drugs, but most work only involves numerical simulations and analysis has lagged. A recent stochastic model of tumour-induced angiogenesis including blood vessel branching, elongation and anastomosis captures some of its intrinsic multiscale structures, yet allows one to extract a deterministic integropartial differential description of the vessel tip density. Here we find that the latter advances chemotactically towards the tumour driven by a soliton (similar to the famous Korteweg-de Vries soliton) whose shape and velocity change slowly. Analysing these collective coordinates paves the way for controlling angiogenesis through the soliton, the engine that drives this process.
Huaier restrains proliferative and invasive potential of human hepatoma SKHEP-1 cells partially through decreased Lamin B1 and elevated NOV
Authors: Hu Zhongdong , Yang Ailin , Su Guozhu , Zhao Yunfang , Wang Ying , Chai Xingyun , Tu Pengfei 
Published: August 2016

AbstractHepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related mortality worldwide. It is urgently needed to develop potential drugs with good efficacy and low toxicity for HCC treatment. The anti-tumor effect of Traditional Chinese Medicine (TCM) has received increasing attention worldwide. Trametes robiniophila Murr. (Huaier) has been used in TCM for approximately 1,600 years. Clinically, Huaier has satisfactory therapeutic effects in cancer treatment, especially in HCC. However, the mechanisms underlying the anti-cancer effect of Huaier remain ill defined. Herein we have demonstrated that Huaier dramatically inhibited cell proliferation and induced apoptosis in human hepatoma cell line SKHEP-1. Importantly, Huaier restrained the metastatic capability of SKHEP-1 cells. Mechanistically, down-regulation of Lamin B1 and up-regulation of Nephroblastoma overexpressed (NOV) were at least partially responsible for the inhibitory effect of Huaier on the proliferative and invasive capacity of SKHEP-1 cells. Our finding provided new insights into mechanisms of anti-HCC effect of Huaier and suggested a new scientific basis for clinical medication.
Plasmonic nanoparticles tuned thermal sensitive photonic polymer for biomimetic chameleon
Authors: Yan Yang , Liu Lin , Cai Zihe , Xu Jiwen , Xu Zhou , Zhang Di , Hu Xiaobin 
Published: August 2016

AbstractAmong many thermo-photochromic materials, the color-changing behavior caused by temperature and light is usually lack of a full color response. And the study on visible light-stimuli chromic response is rarely reported. Here, we proposed a strategy to design a thermo-photochromic chameleon biomimetic material consisting of photonic poly(N-isopropylacrylamide-co-methacrylic acid) copolymer and plasmonic nanoparticles which has a vivid color change triggered by temperature and light like chameleons. We make use of the plasmonic nanoparticles like gold nanoparticles and silver nanoparticles to increase the sensitivity of the responsive behavior and control the lower critical solution temperature of the thermosensitive films by tuning the polymer chain conformation transition. Finally, it is possible that this film would have colorimetric responses to the entire VIS spectrum by the addition of different plasmonic nanoparticles to tune the plasmonic excitation wavelength. As a result, this method provides a potential use in new biosensors, military and many other aspects.
Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism
Authors: Ke Zhang-Hong , Pan Jie-Xue , Jin Lu-Yang , Xu Hai-Yan , Yu Tian-Tian , Ullah Kamran , Rahman Tanzil Ur , Ren Jun , Cheng Yi , Dong Xin-Yan , Sheng Jian-Zhong , Huang He-Feng 
Published: August 2016

AbstractAccumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders. However, the underlying mechanism is still unclear. Using a mouse BPA exposure model, we investigated the effects of long-term BPA exposure on lipid metabolism and the underlying mechanisms. The male mice exposed to BPA (0.5 μg BPA /kg/day, a human relevant dose) for 10 months exhibited significant hepatic accumulation of triglycerides and cholesterol. The liver cells from the BPA-exposed mice showed significantly increased expression levels of the genes related to lipid synthesis. These liver cells showed decreased DNA methylation levels of Srebf1 and Srebf2, and increased expression levels of Srebf1 and Srebf2 that may upregulate the genes related to lipid synthesis. The expression levels of DNA methyltransferases were decreased in BPA-exposed mouse liver. Hepa1-6 cell line treated with BPA showed decreased expression levels of DNA methyltransferases and increased expression levels of genes involved in lipid synthesis. DNA methyltransferase knockdown in Hepa1-6 led to hypo-methylation and increased expression levels of genes involved in lipid synthesis. Our results suggest that long-term BPA exposure could induce hepatic lipid accumulation, which may be due to the epigenetic reprogramming of the genes involved in lipid metabolism, such as the alterations of DNA methylation patterns.
Inhibition of Autophagy Enhances Curcumin United light irradiation-induced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells
Authors: Niu Tianhui , Tian Yan , Mei Zhusong , Guo Guangjin 
Published: August 2016

AbstractMalignant melanoma is the most aggressive form of skin carcinoma, which possesses fast propagating and highly invasive characteristics. Curcumin is a natural phenol compound that has various biological activities, such as anti-proliferative and apoptosis-accelerating impacts on tumor cells. Unfortunately, the therapeutical activities of Cur are severely hindered due to its extremely low bioavailability. In this study, a cooperative therapy of low concentration Cur combined with red united blue light irradiation was performed to inspect the synergistic effects on the apoptosis, proliferation and autophagy in human melanoma A375 cell. The results showed that red united blue light irradiation efficaciously synergized with Cur to trigger oxidative stress-mediated cell death, induce apoptosis and inhibit cell proliferation. Meanwhile, Western blotting revealed that combined disposure induced the formation of autophagosomes. Conversely, inhibition of the autophagy enhanced apoptosis, obstructed cell cycle arrest and induced reversible proliferation arrest to senescence. These findings suggest that Cur combined with red united blue light irradiation could generate photochemo-preventive effects via enhancing apoptosis and triggering autophagy and pharmacological inhibition of autophagy convert reversible arrested cells to senescence, therefore reducing the possibility that damaged cells might escape programmed death.
Increased DNA and RNA damage by oxidation in patients with bipolar I disorder
Authors: Jacoby A S , Vinberg M , Poulsen H E , Kessing L V , Munkholm K 
Published: August 2016

AbstractThe mechanisms underlying bipolar disorder (BD) and the associated medical burden are unclear. Damage generated by oxidation of nucleosides may be implicated in BD pathophysiology; however, evidence from in vivo studies is limited and the extent of state-related alterations is unclear. This prospective study investigated for we believe the first time the damage generated by oxidation of DNA and RNA strictly in patients with type I BD in a manic or mixed state and subsequent episodes and remission compared with healthy control subjects. Urinary excretion of 8-oxo-deoxyguanosine (8-oxodG) and 8-oxo-guanosine (8-oxoGuo), valid markers of whole-body DNA and RNA damage by oxidation, respectively, was measured in 54 patients with BD I and in 35 healthy control subjects using a modified ultraperformance liquid chromatography and mass spectrometry assay. Repeated measurements were evaluated in various affective phases during a 6- to 12-month period and compared with repeated measurements in healthy control subjects. Independent of lifestyle and demographic variables, a 34% (P<0.0001) increase in RNA damage by oxidation across all affective states, including euthymia, was found in patients with BD I compared with healthy control subjects. Increases in DNA and RNA oxidation of 18% (P<0.0001) and 8% (P=0.02), respectively, were found in manic/hypomanic states compared with euthymia, and levels of 8-oxodG decreased 15% (P<0.0001) from a manic or mixed episode to remission. The results indicate a role for DNA and RNA damage by oxidation in BD pathophysiology and a potential for urinary 8-oxodG and 8-oxoGuo to function as biological markers of diagnosis, state and treatment response in BD.
Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
Authors: Blüher Matthias 
Published: August 2016

The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may link accumulation of adipose tissue in obesity to metabolic diseases, although the underlying mechanisms are not completely understood. In the past decades, data from human studies and transgenic animal models strongly suggested correlative, but also causative associations between activation of proinflammatory pathways and insulin resistance. Particularly chronic inflammation in adipose tissue seems to play an important role in the development of obesity-related insulin resistance. On the other hand, adipose tissue inflammation has been shown to be essential for healthy adipose tissue expansion and remodelling. However, whether adipose tissue inflammation represents a consequence or a cause of impaired insulin sensitivity remains an open question. A better understanding of the molecular pathways linking excess adipose tissue storage to chronic inflammation and insulin resistance may provide the basis for the future development of anti-inflammatory treatment strategies to improve adverse metabolic consequences of obesity. In this review, potential mechanisms of adipose tissue inflammation and how adipose tissue inflammation may cause insulin resistance are discussed.
Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology
Authors: Bakeer Nihal , James Jeanne , Roy Swarnava , Wansapura Janaka , Shanmukhappa Shiva Kumar , Lorenz John N. , Osinska Hanna , Backer Kurt , Huby Anne-Cecile , Shrestha Archana , Niss Omar , Fleck Robert , Quinn Charles T. , Taylor Michael D. , Purevjav Enkhsaikhan , Aronow Bruce J. , Towbin Jeffrey A. , Malik Punam 
Published: August 2016

Significance
Sickle cell anemia (SCA) is a common monogenic disorder associated with significant morbidity and mortality and a high incidence of unexplained sudden death in young adults. With the prevention of infections, there is an increasing appreciation for cardiopulmonary complications and a cardiac phenotype that cannot be solely attributed to chronic anemia. We used mouse models of SCA and iron-deficient anemia to show distinct functional, pathological, ultrastructural, and molecular cardiac features causing a unique restrictive cardiomyopathy in SCA that predisposed the myocardium to electrophysiological abnormalities and sudden death. This is a comprehensive longitudinal analysis in preclinical mouse models that unifies the previously reported diverse cardiac phenotypes in SCA, and opens new avenues for early diagnostics and targeted therapies for human SCA-related cardiac disease.
Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease
Authors: Singh Arun , Mewes Klaus , Gross Robert E. , DeLong Mahlon R. , Obeso José A. , Papa Stella M. 
Published: August 2016

Significance
This study is important because it provides the first account of the electrophysiological activity in the human striatum, and it demonstrates major and distinctive abnormalities of neuronal firing in Parkinson’s disease (PD). Up until now, circuit models of PD were based on striatal changes that were never demonstrated in patients. We compared striatal recordings across patients with PD and other neurological disorders [dystonia and essential tremor (ET)], and correlative findings in nonhuman primates. Therefore, the data provided by the present study significantly contribute to understand the role of striatal mechanisms in basal ganglia circuits and in the pathophysiology of PD. Additionally, the study originally reports altered striatal activity in dystonia and activity compatible with unchanged striatal function in ET.
DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds
Authors: Waterworth Wanda M. , Footitt Steven , Bray Clifford M. , Finch-Savage William E. , West Christopher E. 
Published: August 2016

Significance
The DNA checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED play crucial roles in the maintenance of genome stability, safeguarding cellular survival and the faithful transmission of genetic information. Here we show that ATM is an important factor that influences seed quality by linking progression through germination with genome integrity. Our findings provide insight into the roles of DNA damage responses, identifying their importance in regulating germination, a process critical for plant survival in the natural environment and crop production.
Adultery on a grand scale
Authors: Froeliger Nicolas 
Published: August 2016

AbstractThis paper is the second in a series dealing with adaptations of Bob Dylan songs in French. The first one was about the merits and perils of being faithful. This one deals with various strategies that somehow take more liberties with the original material. Four non mutually-exclusive strategies are envisioned: twisting the message, turning ones adaptation into an answer song, disregarding the original lyrics altogether, or tactful shape-shifting. All strategies are supported by examples taken from a vast corpus of songs spanning five decades. The paper end with a discussion of the lessons that can be learned from such exercise for translation studies and for the translation profession as a whole.
On the passage of transcendent messages
Authors: Pym Anthony 
Published: August 2016

Abstract
Translation is one way texts are accorded transcendence, understood as material transfer from a site of utterance. Although frequently construed as a quality of texts or auctorial virtue, transcendence is enacted by receivers (including translators) pulling texts across time and space, transforming them accordingly. Study of a war-commemoration text attributed to Atatürk shows this happening in its transfer to Australia. The historical authorship of the text has been contested, and analysis of its various translations and interpretations reveals competing interests, strategic omissions, distributed intercultural agency, and inscriptions. However, the historians involved in the debate, in both Turkey and Australia, have not sufficiently considered translation analysis, which can find some justification for the questioned text. Further, an ethics of cross-cultural communication might question the translation as an appeal to resolution based not just on the commonness of human suffering but also the shared concealment of guilt.
The causes of the problems in CI in a case of Japanese EFL university students and pedagogical suggestions
Authors: Takahashi Kinuko 
Published: August 2016

Abstract
In the previous study (Takahashi 2010), the omission of rendition was identified as one of the student problems. In the present study, ten undergraduate students interpretation and those of two professional interpreters were compared. It was found that decreasing accuracy of interpretation of the following sentence was identified as one of the student problems. Also, it was examined that there was an interpreting unit where the participants who used natural Japanese expressions in the proceeding sentence but with fillers, resulting in omitting or substituting interpretations in the following sentence. It is suggested that some of the student participants were not able to de-verbalize the English word in the source speech, and resulting eventually in the omission and substitution. Therefore, it is recommended that students should be taught a de-verbalization process (Selescovith,1989) as part of interpreting theory.
Sensitivity study for N-NB-driven modes in JT-60U: boundary, diffusion, gyroaverage, compressibility
Authors: Bierwage A. , Todo Y. , Aiba N. , Shinohara K. 
Published: August 2016

Abstract
The sensitivity of the growth and nonlinear evolution of fast-ion-driven modes is examined with respect to the choice of particle boundary conditions, diffusion coefficients, fast ion gyroradii and bulk compressibility. The primary purpose of this work is to justify the choice of parameters to be used in the self-consistent long-time simulations of fast ion dynamics using global MHD-kinetic hybrid codes that include fast ion sources and collisions. The present study is conducted for a scenario based on the N-NB-driven JT-60U shot E039672, which is subject to abrupt large events (ALE). We use realistic geometry, a realistic fast ion distribution, and focus on experimentally observed harmonics with low toroidal mode numbers n  =  1, 2, 3. The use of realistic boundary conditions and finite Larmor radii for the fast ions is shown to be essential. The usual values

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used for the specific heat ratio (controlling the effect of compressibility) are shown to be reasonable choices. Our method for performing the parameter scans around the threshold for the onset of convective amplification is proposed as a strategy for nonlinear benchmark studies.