bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing patient-centered cancer care: a systematic review of electronic patient-reported outcome measures
Authors: Salmani Hosna , Nasiri Somayeh , Alemrajabi Mahdi , Ahmadi Maryam 
Published: September 2024

BackgroundElectronic Patient-Reported Outcome Measures (ePROMs) have emerged as valuable tools in cancer care, facilitating the comprehensive assessment of patients’ physical, psychological, and social well-being. This study synthesizes literature on the utilization of ePROMs in oncology, highlighting the diverse array of measurement instruments and questionnaires employed in cancer patient assessments. By comprehensively analyzing existing research, this study provides insights into the landscape of ePROMs, informs future research directions, and aims to optimize patient-centred oncology care through the strategic integration of ePROMs into clinical practice.MethodsA systematic review was conducted by searching peer-reviewed articles published in academic journals without time limitations up to 2024. The search was performed across multiple electronic databases, including PubMed, Scopus, and Web of Science, using predefined search terms related to cancer, measurement instruments, and patient assessment. The selected articles underwent a rigorous quality assessment using the Mixed Methods Appraisal Tool (MMAT).ResultsThe review of 85 studies revealed a diverse range of measurement instruments and questionnaires utilized in cancer patient assessments. Prominent instruments such as the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and the Patient Reported Outcome-Common Terminology Criteria for Adverse Events (PRO-CTCAE) were frequently referenced across multiple studies. Additionally, other instruments identified included generic health-related quality of life measures and disease-specific assessments tailored to particular cancer types. The findings indicated the importance of utilizing a variety of measurement tools to comprehensively assess the multifaceted needs and experiences of cancer patients.ConclusionOur systematic review provides a comprehensive examination of the varied tools and ePROMs employed in cancer care, accentuating the perpetual requirement for development and validation. Prominent instruments like the EORTC QLQ-C30 and PRO-CTCAE are underscored, emphasizing the necessity for a thorough assessment to meet the multifaceted needs of patients. Looking ahead, scholarly endeavours should prioritize the enhancement of existing tools and the creation of novel measures to adeptly address the evolving demands of cancer patients across heterogeneous settings and populations.
N2-methylguanosine and N2, N2-dimethylguanosine in cytosolic and mitochondrial tRNAs
Authors: Petrosyan Jonny , Bohnsack Katherine E. 
Published: September 2024

Decoration of cellular RNAs with modified RNA nucleosides is an important layer of gene expression regulation. Throughout the transcriptome, RNA modifications influence the folding, stability and function of RNAs as well as their interactions with RNA-binding proteins. Although first detected more than 50 years ago, the modified nucleosides N2-methylguanosine (m2G) and N2,N2-dimethylguanosine (m22G) have recently come to the fore through the identification and characterization of the human methyltransferases (MTases) responsible for their installation. In tRNAs, m2G and m22G are present at the junctions between the acceptor stem and the D-arm, and the D-arm and the anticodon stem loop. Here, we review the current knowledge on the effects of mono- and di-methylation of N2 of guanosine on base-pairing and provide an overview of m2(2)G sites in cytosolic and mitochondrial tRNAs. We highlight key features of m2G and m22G MTases, and describe how these enzymes specifically recognize their RNA substrates and target nucleosides. We also discuss the impact of these modifications on tRNA functions, their dynamic regulation and their implications in disease.
Bioinformatics Analysis and Expression Features of Terpene Synthase Family in Cymbidium ensifolium
Authors: Wang Mengyao , Liu Baojun , Li Jinjin , Huang Ningzhen , Tian Yang , Guo Liting , Feng Caiyun , Ai Ye , Fu Chuanming 
Published: September 2024

Terpene synthases (TPSs) are crucial for the diversification of terpenes, catalyzing the formation of a wide variety of terpenoid compounds. However, genome-wide systematic characterization of TPS genes in Cymbidium ensifolium has not been reported. Within the genomic database of C. ensifolium, we found 30 CeTPS genes for this investigation. CeTPS genes were irregularly distributed throughout the seven chromosomes and primarily expanded through tandem duplications. The CeTPS proteins were classified into three TPS subfamilies, including 17 TPS-b members, 8 TPS-a members, and 5 TPS-c members. Conserved motif analysis showed that most CeTPSs contained DDxxD and RRX8W motifs. Cis-element analysis of CeTPS gene promoters indicated regulation primarily by plant hormones and stress. Transcriptome analysis revealed that CeTPS1 and CeTPS18 had high expression in C. ensifolium flowers. qRT-PCR results showed that CeTPS1 and CeTPS18 were predominantly expressed during the flowering stage. Furthermore, CeTPS1 and CeTPS18 proteins were localized in the chloroplasts. These results lay the theoretical groundwork for future research on the functions of CeTPSs in terpenoid biosynthesis.
Low-Basicity 5-HT6 Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation
Authors: Zaręba Przemysław , Drabczyk Anna K. , Wnorowski Artur , Maj Maciej , Malarz Katarzyna , Rurka Patryk , Latacz Gniewomir , Duszyńska Beata , Ciura Krzesimir , Greber Katarzyna Ewa , Boguszewska-Czubara Anna , Śliwa Paweł , Kuliś Julia 
Published: September 2024

The serotonin 5-HT6 receptor (5-HT6R), expressed almost exclusively in the brain, affects the Cdk5 signaling as well as the mTOR pathway. Due to the association of 5-HT6R signaling with pathways involved in cancer progression, we decided to check the usefulness of 5-HT6R ligands in the treatment of CNS tumors. For this purpose, a new group of low-base 5-HT6R ligands was developed, belonging to arylsulfonamide derivatives of cyclic arylguanidines. The selected group of molecules was also tested for their antiproliferative activity on astrocytoma (1321N1) and glioblastoma (U87MG, LN-229, U-251) cell lines. Some of the molecules were subjected to ADMET tests in vitro, including lipophilicity, drug binding to plasma proteins, affinity for phospholipids, drug–drug interaction (DDI), the penetration of the membrane (PAMPA), metabolic stability, and hepatotoxicity as well as in vivo cardiotoxicity in the Danio rerio model. Two antagonists with an affinity constant Ki < 50 nM (PR 68 Ki = 37 nM) were selected. These compounds were characterized by very high selectivity. An analysis of pharmacokinetic parameters for the lead compound PR 68 confirmed favorable properties for administration, including passive diffusion and acceptable metabolic stability (metabolized in 49%, MLMs). The compound did not exhibit the potential for drug–drug interactions.
Vivências dos jovens militantes LGBTQIA+ em face às manifestações homofóbicas presentes no convívio escolar em Igarapé-Miri, Pará
Authors: Pantoja Antunes Graciete , Da Silva Lobato Vivian 
Published: September 2024

O presente artigo tem por objetivo analisar as vivências de jovens militantes LGBTQIA+ no processo de escolarização, em face às manifestações homofóbicas presentes no convívio social e escolar em Igarapé-Miri, Pará, Brasil. A abordagem metodológica adotada é a qualitativa, com entrevistas semiestruturadas a 04 (quatro) militantes LGBTQIA+, que já concluíram a educação básica e participaram dos primeiros movimentos para concretizar a militância em Igarapé-Miri. Os resultados apontam o preconceito e a homofobia como problemas que excluem os jovens da perspectiva da sociedade, já que muitas práticas agressivas ocorridas dentro e fora das escolas são oriundas da falta de respeito às diferenças. Isso envolve as diferentes culturas, aprendizados e valores. Nesse sentido, torna-se relevante a escola ter um currículo amplo, voltado para as várias dimensões sociais, possibilitando a formação de cidadãos críticos e reflexivos, independentemente da sua capacidade de concentração, orientação sexual, raça e condição econômica.

Abstract
This article aims to analyze the experiences of young LGBTQIA+ activists in the schooling process in face of homophobic manifestations in social and school life in Igarapé-Miri, Pará, Brazil. We adopted qualitative methodological approach, with semi-structured interviews. The participants were 04 (four) LGBTQIA+ activists who have already completed basic education and participated in the first movements to implement militancy in Igarapé-Miri. The results point to prejudice and homophobia as problems that exclude young people, since many aggressive practices occur inside and outside schools and come from a lack of respect for differences, which involves different cultures, learning and values. In this sense, it is important for schools to have a broad curriculum, focused on the various social dimensions, enabling the formation of critical and reflective citizens regardless their ability to concentrate, sexual orientation, race and economic condition.
Role of Magnetic Arcades in Explaining the Puzzle of the Gamma-Ray Emission from the Solar Disk
Authors: Puzzoni Eleonora , Fraschetti Federico , Kóta József , Giacalone Joe 
Published: September 2024

Abstract
The interpretation of gamma-ray emission originating from the solar disk (0.5° in angular size) as due to the interaction of Galactic Cosmic Rays (GCRs) with the solar atmosphere has remained a central challenge in solar physics. After the seminal work by Seckel, Stanev, and Gaisser based on GCRs’ magnetic mirroring, discrepancies between models and observations persist, indicating the need for a novel approach. The present work focuses on exploring the impact of a closed magnetic field geometry in the low photosphere on the observed gamma-ray flux. We track numerically with the PLUTO code the trajectories of test-particle protons within a static ∼20 Mm scale height magnetic arcade adjacent to jets. By making use of numerical vertical density profiles, we inject particles at distinct chromospheric/photospheric altitudes, mimicking the migration of GCRs from neighboring flux tubes into closed arcades. Remarkably, our model reproduces a flat gamma-ray spectrum below ∼33 GeV, a nearly isotropic emission at ∼10 GeV, both consistent with Fermi-LAT observations, and a near-limb emission at ∼1 TeV. Our model can also reproduce the flux-drop detected by HAWC (∼1 TeV). Finally, we argue that the spectral dip observed at ∼40 GeV may result from the flux suppression at low energy due to the cross-field diffusion, which would produce a cutoff. These findings underscore the pivotal role of closed magnetic field structures in shaping the solar disk gamma-ray emission.
WASP 0346-21: An EL CVn-type Eclipsing Binary with Multiperiodic Pulsations in a Triple System
Authors: Lee Jae Woo , Hong Kyeongsoo , Jeong Min-Ji , Wolf Marek 
Published: September 2024

Abstract
Very Large Telescope/UVES spectroscopic and Transiting Exoplanet Survey Satellite (TESS) photometric observations for WASP 0346-21 allow the direct determination of its physical properties, along with the detection of a circumbinary object and oscillating signals. The high-resolution spectra yielded the radial velocities of all three stars and the atmospheric parameters of T
eff,A = 7225 ± 42 K, [M/H] = 0.30 ± 0.03 dex, and v
A

sin
i

= 78 ± 5 km s−1 of the primary component. The combined analysis of these observations resulted in the fundamental parameters of the eclipsing components and the third light of l
3 = 0.043 ± 0.004, which is consistent with the light contribution of the tertiary star observed in the echelle spectra. WASP 0346-21 A resides within the overlapping main-sequence domain of δ Sct and γ Dor variables, while the secondary component of M
B = 0.185 ± 0.013 M
⊙, R
B = 0.308 ± 0.023 R
⊙, T
eff,B = 10,655 ± 146 K, and L
B = 1.09 ± 0.17 L
⊙ matches well with the low-mass white dwarf (WD) model for Z = 0.01, corresponding to the thick disk population classified by the Galactic kinematics. Multifrequency analyses were performed on the residual TESS data after removing the binarity effects. The low frequencies around 26.348 day−1 and 17.683 day−1 are δ Sct pulsations originating from WASP 0346-21 A, and the high frequencies of 97.996 day−1 and 90.460 day−1 are considered to be extremely low-mass WD oscillations. These results demonstrate that WASP 0346-21 is a hierarchical triple system, consisting of an EL CVn binary with multiperiodic pulsations in each component and a distant outer tertiary.
Determination of the Abundance of Mercury from the Hg ii Line at 5677.10 Å in Late B-type Stars. VII. HD 141556 (χ Lupi)
Authors: Monier Richard 
Published: September 2024

Abstract
The weak line of Hg ii located at 5677.10 Å is used to measure the mercury abundance in the most massive component of the double-lined spectroscopic binary HgMn star HD 141556 (χ Lupi). This line is detected at 3σ above the noise in the adjacent continuum. The synthesis of this line confirms a large overabundance of mercury, about +5.30 dex, which is about twice the excess derived from the 3983.93 Å line in earlier studies. Spectrum synthesis yields estimates of the abundance deficiencies/excesses for fourteen other elements which agree well with previous measurements.
Christian Huygens and William Derham and 18th Century Precursors to the Habitable Zone
Authors: Smith Graeme H. 
Published: September 2024

Abstract
Both Christian Huygens and William Derham expressed ideas that are prescient to the concept of a circumstellar habitable zone: liquid water is a precondition for life, there is a region within the solar system within which liquid surface water can exist upon planets, the stars are suns around which planetary systems should be common, these extrasolar planetary systems may include habitable worlds. Although neither author explicitly developed the phraseology of an exoplanetary habitable zone based upon liquid water, such a concept would follow from their writings.
Imaging in Shadows: A Comparison of Craters Observed in Primary and Secondary Illumination with the Lunar Reconnaissance Orbiter Camera
Authors: Martin A. C. , Denevi B. W. , Speyerer E. J. , Boyd A. K. , Brown H. M. 
Published: September 2024

Abstract
By definition, permanently shadowed regions (PSRs) never receive primary illumination from the Sun. However, most receive secondary illumination reflected from crater walls and nearby massifs. The nature of that secondary illumination, diffuse lighting that can vary significantly across small distances, complicates interpretations of geologic features. To better understand secondary illumination and aid in interpreting images of PSRs, we analyzed a collection of long-exposure Lunar Reconnaissance Orbiter Camera (LROC) Narrow Angle Camera (NAC) images of five equatorial craters collected when the crater interiors were mainly in shadow, using these as analog images for PSR illumination conditions but enabling comparisons with LROC NAC images of the same features under direct primary illumination. Using illumination models, we quantified the range of secondary photometric angles contributing to illuminating each pixel in the shadowed terrain and measured reflectance under secondary illumination. The phase angles of secondary illumination (secondary phase angles) contributing to a pixel can be well represented by the median value of contributing illumination weighted by magnitude. We show that features observed to have approximately constant albedo in primary illumination show substantial variations in reflectance across the scene in secondary illumination depending on the median secondary phase angle. Approximately 30% of craters with high-reflectance ejecta deposits are detectable in secondary illumination; only when the reflectance contrast is high (>1.3 times higher than the background reflectance in primary illumination) are a majority (>70%) of these deposits detectable in secondary illumination, meaning that small albedo differences will be hard to detect in images of PSRs.
The G Protein–Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration
Authors: Palacios Daniel , Majhi Rakesh Kumar , Szabo Edina K , Clement Dennis , Lachota Mieszko , Netskar Herman , Penna Leena , Krokeide Silje Z , Vincenti Marianna , Kveberg Lise , Malmberg Karl-Johan 
Published: September 2024

Abstract
G protein–coupled receptors (GPCRs) represent the largest family of surface receptors and are responsible for key physiological functions, including cell growth, neurotransmission, hormone release, and cell migration. The GPCR 56 (GPR56), encoded by ADGRG1, is an adhesion GPCR found on diverse cell types, including neural progenitor cells, melanoma cells, and lymphocytes, such as effector memory T cells, γδ T cells, and NK cells. Using RNA-sequencing and high-resolution flow cytometry, we found that GPR56 mRNA and protein expression increased with NK cell differentiation, reaching its peak in adaptive NK cells. Small interfering RNA silencing of GPR56 led to increased spontaneous and chemokine-induced migration, suggesting that GPR56 functions as an upstream checkpoint for migration of highly differentiated NK cells. Increased NK cell migration could also be induced by agonistic stimulation of GPR56 leading to rapid internalization and deactivation of the receptor. Mechanistically, GPR56 ligation and downregulation were associated with transcriptional coactivator with PDZ-binding motif translocation to the nucleus and increased actin polymerization. Together, these data provide insights into the role of GPR56 in the migratory behavior of human NK cell subsets and may open possibilities to improve NK cell infiltration into cancer tissues by releasing a migratory checkpoint.
Context factors for implementation of clinical recommendations for chronic musculoskeletal pain
Authors: Ernstzen Dawn V. , Louw Quinette A. 
Published: September 2024

Background: Implementing evidence-informed clinical practice recommendations is important for managing chronic musculoskeletal pain (CMSP) to address the multidimensional impact of the condition. Successful implementation of recommendations requires understanding the multiple context factors that influence CMSP management in different settings.Aim: This study aims to explore contextual factors that could influence the implementation of evidence-informed clinical practice recommendations for the primary health care of adults with CMSP.Setting: The study focused on the primary health care (PHC) sector in Cape Town, South Africa.Methods: A qualitative descriptive study was conducted. A multidisciplinary panel of 13 local health care professionals participated in focused group discussions. The participants considered multimodal clinical recommendations derived from published clinical practice guidelines. In four focus group discussions (three or four members per group), the panel generated and documented context factors that would influence implementing the recommendations in practice. Inductive content analysis was performed to identify categories and themes.Results: The five contextual themes generated indicated health care system organisation, human resource requirements, provider practice patterns, patient empowerment and integration into policy as imperative for the successful implementation of recommendations.Conclusion: There are diverse context factors that could influence the implementation of clinical recommendations for managing CMSP in PHC settings. Identifying these factors as barriers or facilitators is beneficial for developing effective knowledge translation strategies.Contribution: The study findings indicate that an integrated systems approach supported by health care policy and multisectoral collaboration is needed to successfully implement clinical recommendations to address the impact of CMSP.
An Evaluation of Mental Health Knowledge and Stigma in Medical College Students in Rural Western Maharashtra
Authors: Waghjale Shatakshi Ramesh , Arya Ashish Baldev , Ubhale Ashish Suresh 
Published: September 2024

Abstract

Background:
As per the World Health Organization, stigma is a major barrier to get professional psychological help. Various studies have pointed to the need for shifting focus to enhance the knowledge of doctors and medical students in whom mental health issues are very common and can eventually lead to unfavorable outcomes for the students as well as the whole society.

Materials and Methods:
A cross-sectional study on MBBS UG students from a private medical college was conducted. Three scales, Mental Health Knowledge (MAK) Schedule, Stigma Scale of Seeking Help (SSOSH) Scale, and Stigma Scale for Receiving Psychological Help (SSRPH), were used.

Results:
Total 515 responses were received, out of which 47% were male and 53% were female. Overall, on the SSRPH and SSOSH Scale, the mean score was 6.02 and 29.67, whereas standard deviation (SD) 2.75 and 2.69 respectively, which showed that stigma was moderate among students. The MAK Scale showed that students have a high level of knowledge, with a mean score of 44.31 and SD 8.49. Furthermore, there is a negative correlation between MAK and SSRPH and SSOSH, as suggested by Pearson’s coefficient −0.25 and −0.41, respectively.

Conclusion:
The students showed moderate degrees of stigma, and they displayed a high level of knowledge in regard to mental health. The results likewise found that there is a negative correlation between the stigma and the degree of knowledge in regard to mental health. It shows up from this that raising information about mental health could possibly reduce stigma and encourage students in medical colleges to look for therapy when they need it.
Comparison between Combination of Proximal Adductor Canal Block and Infiltration between Popliteal Artery and Capsule of Knee (iPACK) with Large-Volume Distal Adductor Canal Block in Facilitating Early Mobilization after Total Knee Replacement: A Randomized, Single-Blind Study
Authors: Pryambodho Pryambodho , Kwan Lawrence , Tantri Aida Rosita , Lubis Andri Maruli Tua 
Published: September 2024

Abstract

Background:
Adductor canal block (ACB) and infiltration between popliteal artery and capsule of knee (iPACK) are popular block methods for analgesia after total knee replacement (TKR), covering both the anterior and posterior knee. This study aimed to compare the performance of the combination of ACB and iPACK with large-volume distal ACB in facilitating early mobilization after TKR.

Patients and Methods:
This study was a single-blind, randomized, controlled trial of 30 subjects who underwent TKR. Subjects were randomly assigned to either Group A (the large-volume distal ACB) or Group B (the combination of proximal ACB and iPACK). Outcome variables included postoperative time up and go (TUG) test, numeric rating scale (NRS), postoperative morphine consumption, block-performing time, time to first opioid rescue analgesia, and side effects.

Results:
This study found that the block-performing time was significantly shorter in Group A compared to Group B (230.67 vs. 509.67, P < 0.001). The mean postoperative TUG test (67 vs. 64, P = 0.78), NRS at all-time points, and postoperative morphine consumption (3 vs. 3 mg, P = 0.85) did not differ significantly. No block-related side effects were found in either group.

Conclusion:
Large-volume distal ACB is not superior to the combination of proximal ACB and iPACK in facilitating early mobilization after TKR. Block-performing time of distal ACB was shorter compared to the combination of proximal ACB and iPACK.