bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocean Planning and Conservation in the Age of Climate Change: A Roundtable Discussion
Authors: Frazão Santos C , Agardy T , Crowder L B , Day J C , Himes-Cornell A , Pinsky M L , Reimer J M , Gissi E 
Published: September 2024

Synopsis
Over recent years, recognition of the need to develop climate-smart marine spatial planning (MSP) has gained momentum globally. In this roundtable discussion, we use a question-and-answer format to leverage diverse perspectives and voices involved in the study of sustainable MSP and marine conservation under global environmental and social change. We intend this dialogue to serve as a stepping stone toward developing ocean planning initiatives that are sustainable, equitable, and climate-resilient around the globe.
Falls and malnutrition are associated with in-hospital mortality in patients with cirrhosis
Authors: Abedin Nada , Hein Moritz , Queck Alexander , Mücke Marcus M. , Weiler Nina , Pathil Anita , Mihm Ulrike , Welsch Christoph , Bojunga Jörg , Zeuzem Stefan , Herrmann Eva , Dultz Georg 
Published: September 2024

Background:
Hospitalized patients with end-stage liver disease are at risk of malnutrition, reduced body function, and cognitive impairment due to HE. This combination may have an impact on in-hospital falls and mortality. The purpose of this study was to identify factors associated with the risk of falls and to analyze the consequences regarding in-hospital mortality.

Methods:
We performed a retrospective analysis of patients hospitalized with liver cirrhosis between 2017 and 2019 at the Department of Gastroenterology at the University Hospital Frankfurt. Clinical data, laboratory work, and follow-up data were analyzed. Factors associated with the risk of falls and in-hospital mortality were calculated using a mixed effect poisson regression model and competing risk time-to-event analyses.

Results:
Falls occurred with an incidence of 4% (80/1985), including 44 injurious falls with an incidence rate of 0.00005/100 patient-days (95% CI: 0.00001–0.00022). In the multivariate analysis malnutrition (incidence risk ratio: 1.77, 95% CI: 1.04–3.04) and implanted TIPS (incidence risk ratio: 20.09, 95% CI: 10.1–40.1) were independently associated with the risk of falling. In a total of 21/80 (26.25%) hospitalizations, patients with a documented fall died during their hospital stay versus 160/1905 (8.4%) deaths in hospitalizations without in-hospital fall. Multivariable analysis revealed as significant clinical predictors for in-hospital mortality a Nutritional Risk Screening ≥2 (HR 1.79, 95% CI: 1.32–2.4), a falling incident during hospitalization (HR 3.50, 95% CI: 2.04–6.0), high MELD, and admission for infections.

Conclusions:
Malnutrition and TIPS are associated with falls in hospitalized patients with liver cirrhosis. The in-hospital mortality rate of patients with cirrhosis with falls is high. Specific attention and measures to ameliorate these risks are warranted.
Cryptogenic organizing pneumonia caused by solanine: A case report
Authors: Wang Linying , Zhang Lvjun , Ying Chiqing , Jin Xuehang , Ying Mingliang , Chen Hui , Zhu Dan 
Published: September 2024

Rationale:
Cryptogenic organizing pneumonia (COP) is a type of pneumonia with unknown cause, presenting with symptoms like dyspnea, fever, and cough. Solanine poisoning can cause symptoms like increased heart rate, rapid breathing, sore throat, diarrhea, vomiting, and fever, but there are no known cases of it causing COP.

Patient concerns:
A 43-year-old man had a dry cough, worse at night, with phlegm and chest tightness after eating sprouted potatoes. No history of surgeries or family medical issues.

Diagnosis:
Laboratory tests and metagenomic next-generation sequencing of bronchoalveolar lavage fluid from the bilateral lower lobes did not yield a definitive pathogen. Further evaluation included testing for vasculitis-associated antibodies and rheumatologic immune markers for myositis spectra to rule out connective tissue disease-associated interstitial lung disease as the etiology of organizing pneumonia. As a result, the final diagnosis was determined to be COP.

Interventions:
The patient received glucocorticoid therapy and oxygen therapy, and responded well to the treatment.

Outcomes:
On the 10th day of hospitalization, the patient was discharged with success. A follow-up chest CT conducted over a month later revealed that the lesions in both lungs had essentially resolved, with only minor residual fibrotic changes present.

Lessons:
Regularly monitoring disease progression is crucial for patients with solanine poisoning who have pulmonary symptoms. Promptly conducting chest CT scans and bronchoscopy is advised to check for any infections. It is also important to rule out pneumonia related to connective tissue disease-associated interstitial lung disease and provide appropriate treatment promptly.
Factors related to self-care in Korean patients with tuberculosis: A systematic review and meta-analysis
Authors: Lee Hye Kyung , Lee Go Un 
Published: September 2024

Background:
Tuberculosis (TB) remains a major public health challenge in South Korea which has one of the highest TB incidence rates among the Organisation for Economic Co-operation and Development (OECD) countries. Effective self-care, including medication adherence and regular hospital visits, is crucial for successful TB treatment and the prevention of drug resistance. TB self-care in South Korea is influenced by cultural, social, and systemic factors. This study aimed to systematically review and conduct a meta-analysis of factors influencing self-care among Korean patients with TB, providing evidence-based insights for developing effective self-care promotion programs.

Methods:
A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, focusing on quantitative studies published since 2000 involving Korean patients with TB. Twenty studies were included in the final analysis, and 44 factors related to self-care were categorized into sociodemographic, TB-related, psychological, environmental, and educational characteristics. Effect sizes were calculated using Comprehensive Meta-Analysis (CMA) 4.0, with the assessment of heterogeneity and publication bias.

Results:
The meta-analysis ranked the effect sizes of the different characteristic categories as follows: environmental > educational > psychological. Among the individual factors, social support had the greatest influence on self-care, followed by quality of life, self-efficacy, nonfamily support, family support, and perceived health benefits. These findings underscore the critical role of sustained social support from the community, medical staff, and family in enhancing self-care among TB patients.

Conclusion:
Effective self-care strategies for patients with TB should focus on interventions that strengthen the environmental, educational, and psychological aspects. These findings suggest that similar approaches can be applied in other countries facing comparable healthcare challenges. This study acknowledges limitations including potential publication bias and the exclusion of older studies and non-Korean patient studies, highlighting the need for further research across diverse settings and populations.
At-Home Care Versus Total Hospital Care Model for Autologous Stem Cell Transplantation in Adult Lymphoma Patients
Authors: Hernández-Aliaga Marina , Carretero-Márquez Carlos , Peña Carlos Javier , Santacatalina-Roig Enric , Navarro-Martínez Rut 
Published: September 2024

Background
Lymphoma is the second most prevalent cancer treated with autologous stem cell transplantation (ASCT). Additional resources are required to enhance the provision of care for these patients.

Objective
To explore the complications and economic costs of home versus hospital care models for ASCT in patients diagnosed with lymphoma and to describe the experience of home care patients.

Methods
This was an observational pilot case-control study with 1:1 matching, in which all patients assisted at home were included. Data were obtained by reviewing medical records and data from the hospital’s financial and resource management service. The IEXPAC scale version 11 + 4 was used to assess the care process experience as perceived by home care patients.

Results
The study included 34 patients, in which there was a significant decrease in neutropenic fever, both in frequency and duration (P = .001 and P < .001, respectively), in mucositis days (P = .038), and the rate of red cell concentrate transfusion (P < .001); however, there was a longer neutrophil recovery time (P = .044) in home care versus hospitalized patients. The overall cost was higher in the hospital care model (P = .001). Home care patients obtained high scores on the perceived experience of the care process scale.

Conclusions
The home ASCT model is associated with fewer complications, shorter hospital stays, and more significant cost savings. The experience of the home care process was rated satisfactorily.

Implications for Practice
This study provides evidence for a model that offers high-quality care and a comfortable experience for ASCT patients. Preparing more nurses for this home care model is imperative.
Effect of the ACTN3 R577X Polymorphism on Serum Creatine Kinase and Interleukin-6 Levels after Maximal Eccentric Exercise
Authors: Deguchi Minoru , Homma Hiroki , de Almeida Kathleen Y. , Kozuma Ayumu , Saito Mika , Tsuchiya Yosuke , Kouzaki Karina , Ochi Eisuke , Okamoto Takanobu , Nakazato Koichi , Kikuchi Naoki 
Published: September 2024

Abstract

Objective
This study explored the interaction among ACTN3 R577X polymorphism, muscle damage, and post-exercise inflammatory response by assessing changes over time in serum creatine kinase and interleukin-6 levels.

Design
Ninety-five active Japanese participants (50 men and 45 women: 22.2 ± 2.3 years) who did not perform daily upper limb strength exercises were enrolled. Participants executed five sets of six maximal eccentric elbow flexion exercises. The exercise duration was 9 min, including rest between sets (90 s). Maximum voluntary isometric contraction, range of motion, muscle soreness, and serum creatine kinase and interleukin-6 levels were assessed pre and post and 1, 2, 3, and 5 d after exercise. Genotype groups were classified as RR + RX and XX based on the absence of ACTN3 expression.

Results
A significant time and group interaction (p = 0.045) on creatine kinase levels was observed between the groups, indicating that the absence of ACTN3 significantly affects creatine kinase changes. Conversely, no significant interaction on change in interleukin-6, maximum voluntary isometric contraction, range of motion, and muscle soreness was observed between groups.

Conclusion
The results highlight an interaction on creatine kinase activity post-exercise by ACTN3 R577X polymorphism, with elevated activity in the XX genotype.
Outcomes of proprioceptive training on recovery after anterior cruciate ligament reconstruction: A systematic review and meta-analysis
Authors: Huang Lei , You Guixuan , Li Minghui , Xia Zhangrong , Yang Siyi , Zhou Xin , Shi Houyin , Wang Dingxuan , Zhang Lei 
Published: September 2024

Abstract

Objective
The study was designed to explore the effect of proprioceptive training in contrast to conventional training among individuals following anterior cruciate ligament reconstruction (ACLR). It includes joint position sense (JPS), subjective functional outcomes (Cincinnati, Knee injury Osteoarthritis Outcome Score, International Knee Documentation Committee knee form), muscle strength, pain, and kinesthesia.

Methods
PubMed, EMBASE, The Cochrane Library, and Web of Science databases were searched. Quality assessment was performed through the Cochrane Risk of Bias tool and GRADE system. The standardized mean deviation (SMD) was selected as the effect size.

Results
Fifteen studies and 537 participants were included. Compared with conventional training, proprioceptive training may significantly enhance passive JPS (SMD = -1.87 [95%CI: -2.39 to -1.34]) and single-leg hop function test performance (SMD = 0.29 [95%CI 0.04 to 0.54]). Data also indicated that proprioceptive training can moderately improve subjective functional outcomes (SMD = 0.61 [95%CI, 0.23 to 0.99]). However, there were no significant effects on active JPS, muscle strength and VAS.

Conclusion
Proprioceptive training has the potential to yield beneficial effects on knee passive JPS, hop functional test and subjective functional outcomes in patients after ACLR. However, its impact on enhancing knee active JPS and kinesthesia may not be statistically significant.
Preventing the Next Neglected Pessary: A Quality Improvement Initiative
Authors: Popiel Patrick , Maggi Maralyn , Dalal Shana , Curran Meghan , Rickey Leslie M. 
Published: September 2024

Importance
Pessaries are commonly used to manage pelvic organ prolapse. Pessary management can be done by a medical professional or the patient themselves. Pessary complications are rare. However, pessaries can be difficult to track, and patients who are lost to follow-up are at an increased risk of complications such as vaginal ulceration, pessary embedment, and fistulization.

Objectives
To create and implement a quality improvement initiative focusing on preventing neglected pessaries.

Study Design
Through the electronic medical record, we implemented a quality improvement initiative focused on creating a workflow where a pessary can be designated as an implant when inserted. A year after implementation, data was gathered.

Results
We identified 37% (55/147) of patients without follow-up in the 3 months after pessary placement. Of those, 24% were no longer using pessaries, 24% were self-maintaining or having surveillance with their primary OB/GYN, 16% had surgery for pelvic organ prolapse since placement of the pessary, 15% were lost to follow-up and were considered to be patients “at risk,” and 12% did not have a pessary placed to begin with. Review showed 53% of patients with proper documentation and designation of pessary as an implant.

Conclusions
This quality improvement initiative can identify patients lost to follow-up, leading to improved patient care and potential to prevent complications.
Trauma care and its financing around the world
Authors: Chao Tiffany E. , Chu Kathryn , Hardcastle Timothy C. , Steyn Elmin , Gaarder Christine , Hsee Li , Otomo Yasuhiro , Vega-Rivera Felipe , Coimbra Raul , Staudenmayer Kristan 
Published: September 2024

ABSTRACT
Worldwide, one billion people sustain trauma, and 5 million people will die every year from their injuries. Countries must build trauma systems to effectively address this high-burden disease, but efforts are often challenged by financial constraints. Understanding mechanisms for trauma funding internationally can help to identify opportunities to address the burden of injuries. Trauma leaders from around the world contributed summaries around how trauma is managed across their respective continents. These were aggregated to create a comparison of worldwide trauma systems of care. The burden of injuries is high across the world's inhabited continents, but trauma systems remain underfunded worldwide and, as a result, are overall underdeveloped and do not rise to the levels required given the burden of disease. Some countries in Africa and Asia have invested in financing mechanisms such as road accident funds or trauma-specific funding. In Latin America, active surgeon involvement in accident prevention advocacy has made meaningful impact. All continents show progress in trauma system maturation. This article describes how different regions of the world organize and commit to trauma care financially. Overall, while trauma tends to be underfunded, there is evidence of change in many regions and good examples of what can happen when a country invests in building trauma systems.

LEVEL OF EVIDENCE
Expert Opinions; Level VII.
Blood and cerebrospinal fluid biomarkers in neuro-oncology
Authors: Rudà Roberta , Pellerino Alessia , Soffietti Riccardo 
Published: September 2024

Purpose of review
The purpose of this review is to discuss the value of blood and CSF biomarkers in primary CNS tumors.

Recent findings
Several analytes can be assessed with liquid biopsy techniques, including circulating tumor cells, circulating cell-free tumor DNA, circulating cell-free RNA, circulating proteins and metabolites, extracellular vesicles and tumor-educated platelets. Among diffuse gliomas of the adult, ctDNA in blood or CSF has represented the most used analyte, with the detection of molecular alterations such as MGMT promoter, PTEN, EGFRVIII, TERT promoter mutation and IDH R132H mutation. In general, CSF is enriched for ctDNA as compared with plasma. The use of MRI-guided focused ultrasounds to disrupt the blood–brain barrier could enhance the level of biomarkers in both blood and CSF. The detection of MYD88 L265P mutation with digital droplet PCR and the detection of ctDNA with next generation sequencing represent the best tools to diagnose and monitoring CNS lymphomas under treatment. In meningiomas, the low concentration of ctDNA is a limiting factor for the detection of driver mutations, such as NF2, AKTs, SMO, KLF4, TRAF7, SMARCB1, SMARCE1, PTEN, and TERT; an alternative approach could be the isolation of ctDNA through circulating extracellular vesicles. Liquid biopsies are being used extensively for diagnosis and surveillance of diffuse midline gliomas, in particular with the detection of the driver mutation H3K27M. Last, specific methylome patterns in CSF may allow the distinction of glioblastomas from CNS lymphomas or meningiomas.

Summary
This review summarizes the current knowledge and future perspectives of liquid biopsy of blood and CSF for diagnosis and monitoring of primary CNS tumors.
Orientation-resolved attosecond photoionization delays in the
N2O
molecule
Authors: González-Collado Celso M. , Cattaneo Laura , Plésiat Etienne , Omiste Juan J. , Vos Jannie , González-Vázquez Jesús , Decleva Piero , Keller Ursula , Palacios Alicia , Martín Fernando 
Published: September 2024

We present a thorough theoretical and experimental investigation of photoionization time delays in the N2O molecule. Our theory provides actual XUV+IR time-resolved photoelectron spectra as measured in real reconstruction of attosecond beating by interference of two-photon transitions (RABBIT) experiments. This requires not only accounting for the interaction between the XUV field and the neutral molecule, but also between the IR field and the ejected electron, which is only possible through explicit evaluation of a large number of dipole couplings between molecular electronic continuum states. To compare with the results of these calculations we have performed RABBIT experiments in which the ejected electron and the resulting ionic fragments are measured in coincidence, thus allowing us to obtain photoionization delays for a particular orientation of the molecule with respect to the polarization of the XUV and IR fields. We have found very good agreement between calculated and measured RABBIT spectra for both nondissociative and dissociative ionization channels. In particular, we unambiguously show a photoionization delay of about 60 as in the vicinity of a well-known shape resonance of N2O in the nondissociative ionization channel. More importantly, we show a dramatic effect of the IR field in the orientation-resolved ionization delays in the whole photon energy range investigated in this paper (18–40 eV), even at the level of ionization delays (i.e., delays referred to an internal reference delay) where the effect of the IR field is generally assumed to cancel out. Finally, we explicitly show that the problem of spectral congestion inherent to most molecular systems, which usually prevents extraction of photoionization delays, is substantially alleviated by resolving the molecular orientation or, ideally, by resolving both the molecular orientation and the electron emission angle, where access to perfectly isolated ionization channels is possible at specific angles.

Published by the American Physical Society
2024
Investigating business process changes: a framework for identifying outdated process models
Authors: Avila Diego Toralles , Sanchez Encarna Sosa , Fantinato Marcelo , Polančič Gregor , Thom Lucineia Heloisa 
Published: September 2024

PurposeDue to a lack of event data, organizations using Business Process Management may struggle to update their process models whenever business process changes occur. As such, alternative data sources are needed to detect and monitor business process changes.Design/methodology/approachWe conducted interviews with domain experts to analyze real business processes and classify any identified changes using Reijers and Mansar's framework on business process redesign heuristics. Based on the results, we proposed a taxonomy of entity groups as well as a method for identifying entities in process models based on the taxonomy. With this method, we define how to create a mapping between entities and process models, forming a framework to identify outdated process models through monitoring the entities.FindingsThe analyses of 25 business processes let us define three entity groups that form our taxonomy. We confirmed the feasibility of our entity identification method by classifying process elements of 85 pre-existing process models according to the taxonomy. Regarding the mapping that forms the basis of our framework, we found it necessary to define requirement recommendations to ensure its consistency and rigor.Originality/valueThis study offers a novel approach to handling the challenges of business process change. By emphasizing the identification and use of entities in the analysis of business process changes, it provides a holistic approach to monitoring the work systems of an organization.
Innovations with sustainability potential within the ultra-fast business model
Authors: Uchańska-Bieniusiewicz Anita 
Published: September 2024

Purpose
This paper aims to investigate the process and business model innovations within the ultra-fast business model (UFBM) that have potential sustainable applications.

Design/methodology/approach
An exploratory multiple case study research method was used, emphasizing on an integrative literature review and focusing on two successful Chinese-origin companies that have revolutionized the e-commerce market: Shein and Temu.

Findings
Although the UFBM adopted by these companies remains highly controversial and is commonly associated with harmful business practices and lack of business responsibility, both have managed to develop process and business model innovations that may interest sustainability-driven organizations. They have implemented their unique versions of the customer-to-manufacturer (C2M) production system, which reduces costs and facilitates information exchanges between customers and manufacturers, thereby achieving a better product-market fit. Further still, they have redefined the shopping experience through their interpretations of collaborative consumption, as manifested in live and social commerce, gamification and group buying formats.

Originality/value
Instead of dismissing the UFBM due to its negative environmental and societal impacts, the study concentrates on process and business model innovations that have a potential for sustainability. That does not mean praising the business model as a whole, but instead indicating its potentially interesting aspects that could serve as inspirations for managers and business leaders who are concerned with sustainability. Learning from others' experiences is a recognized business practice, and in this case, could be particularly beneficial for companies with limited resources or opportunities for experimentation.