bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective Weight Loss for Children: A Meta‐analysis of Intervention Studies 2002–2015
Authors: Snethen Julia A. , Broome Marion E. , Treisman Pamela , Castro Erica , Kelber Sheryl T. 
Published: April 2016

AbstractBackgroundInvestigators have implemented a variety of strategies for managing and treating childhood overweight and obesity over the past decade, yet the high prevalence of childhood overweight or obesity remains. The aim of this meta‐analysis was to examine the effectiveness of childhood overweight or obesity interventions addressing weight loss from 2002–September 2015.MethodsThe population focused on in this review were children who were overweight. The treatment group interventions focused on weight loss for overweight children, and included dietary, physical activity, life style changes, or a combination of treatments. Control groups received no treatment other than what they would usually receive in their normal daily lives including standard healthcare assessments. Outcomes for the studies were focused on whether the overweight children in the treatment groups lost weight.ResultsThe criteria for the meta‐analysis were met by 16 intervention studies, with a total of 19 outcomes reported within those studies. Two thousand, three hundred and seventeen participants ranged from 6 to 15 years of age with a mean age of 12 years or less. The majority of the 16 studies were conducted outside the United States (n
= 13), with half reporting data on the cost of running the programming (n
= 8) and were overwhelmingly conducted by interdisciplinary teams without nurses as members of the team (n
= 13). The M
effect was g
= .732, p
< .001 with a 95% confidence interval of 0.351 to 1.113, with quality scores ranging from 20 to 29 out of a possible 41. The heterogeneity analyses overall Q score was 378, an I‐squared of 95, with a fail‐safe N
of 415.Linking Evidence to ActionDiverse interventions included in this meta‐analysis had a significant positive effect on weight loss in overweight children. Future research needs to focus on the role of the nurse in ensuring development and translation of the effective interventions in real world settings, at a scale that would move beyond small segments of the affected populations of overweight children.
Complete Genome Sequence of
Pseudomonas balearica
DSM 6083
T
Authors: Bennasar-Figueras Antoni , Salvà-Serra Francisco , Jaén-Luchoro Daniel , Seguí Carolina , Aliaga Francisco , Busquets Antonio , Gomila Margarita , Moore Edward R. B. , Lalucat Jorge 
Published: April 2016

ABSTRACT

The whole-genome sequence of
Pseudomonas balearica
SP1402 (DSM 6083
T
) has been completed and annotated. It was isolated as a naphthalene degrader from water of a lagooning wastewater treatment plant.
P. balearica
strains tolerate up to 8.5% NaCl and are considered true marine denitrifiers.
Draft Genome Sequence of
Bacillus clausii
UBBC07, a Spore-Forming Probiotic Strain
Authors: Upadrasta Aditya , Pitta Swetha , Madempudi Ratna Sudha 
Published: April 2016

ABSTRACT

Bacillus clausii
UBBC07 is a safe endospore-forming strain, characterized for defined therapeutic effects. The finished draft whole-genome sequence is presented here to scan its genetic constitution for its expanded use as a probiotic in various health sectors.
Draft Genome Sequence of
Xylella fastidiosa
subsp.
fastidiosa
Strain Stag's Leap
Authors: Chen J. , Wu F. , Zheng Z. , Deng X. , Burbank L. P. , Stenger D. C. 
Published: April 2016

ABSTRACT

Xylella fastidiosa
subsp.
fastidiosa
causes Pierce's disease of grapevine. Presented here is the draft genome sequence of the Stag's Leap strain, previously used in pathogenicity/virulence assays to evaluate grapevine germplasm bearing Pierce's disease resistance and a phenotypic assessment of knockout mutants to determine gene function.
Draft Genome Sequence of an Atypical Strain of
Streptococcus pneumoniae
Serotype 19A Isolated from Cerebrospinal Fluid
Authors: Perez-Maya Antonio Ali , Hinojosa-Robles Rosa Maria , Barcenas-Walls Jose Ramon , Rojas-Martinez Augusto , Barrera-Saldaña Hugo Alberto , Ortiz-Lopez Rocio 
Published: April 2016

ABSTRACT

We present here the draft genome sequence of
Streptococcus pneumoniae
strain MTY32702340SN814 isolated in Monterrey, Mexico, from a girl with bacterial meningitis. The strain belongs to the atypical and multidrug-resistant serogroup 19A. This is the first report in the literature of sequence type 3936 (ST3936) in
S. pneumoniae
serotype 19A.
Complete Genome Sequence of
Salmonella enterica
Serovar Typhimurium Strain SO3 (Sequence Type 302) Isolated from a Baby with Meningitis in Mexico
Authors: Vinuesa Pablo , Puente José L. , Calva Edmundo , Zaidi Mussaret B. , Silva Claudia 
Published: April 2016

ABSTRACT

The complete genome of
Salmonella enterica
serovar Typhimurium strain SO3 (sequence type 302), isolated from a fatal meningitis infection in Mexico, was determined using PacBio technology. The chromosome hosts six complete prophages and is predicted to harbor 51 genomic islands, including 13 pathogenicity islands (SPIs). It carries the
Salmonella
virulence plasmid (pSTV).
Complete Genome Sequence of Zika Virus from the First Imported Case in Mainland China
Authors: Liu Lin , Wu Wei , Zhao Xiang , Xiong Ying , Zhang Shuo , Liu Xiaoqing , Qu Jing , Li Jiandong , Nei Kai , Liang Mifang , Shu Yuelong , Hu Guoliang , Ma Xuejun , Li Dexin 
Published: April 2016

ABSTRACT
The first case of Zika virus infection was identified in a Chinese traveler returning from Venezuela in February 2016. This report describes the complete genome sequence of Zika virus from the first imported case in China. The genome sequence analysis showed that the Zika virus isolated in this case belongs to the Asian lineage.
Genome Sequence of
Aeromicrobium erythreum
NRRL B-3381, an Erythromycin-Producing Bacterium of the
Nocardioidaceae
Authors: Harrell Erin A. , Miller Eric S. 
Published: April 2016

ABSTRACT

Aeromicrobium erythreum
NRRL B-3381 has a 3,629,239-bp circular genome that has 72% G+C content. There are at least 3,121 coding sequences (CDSs), two rRNA gene operons, and 47 tRNAs. The genome and erythromycin (
ery
) biosynthetic gene sequences provide resources for metabolic and combinatorial engineering of polyketides.
Draft Genome Sequence of a Novel Marine Bacterium,
Paraglaciecola
sp. Strain S66, with Hydrolytic Activity against Seaweed Polysaccharides
Authors: Schultz-Johansen Mikkel , Glaring Mikkel A. , Bech Pernille K. , Stougaard Peter 
Published: April 2016

ABSTRACT

A novel agarolytic gammaproteobacterium,
Paraglaciecola
sp. S66, was isolated from marine samples of eelgrass (
Zostera
sp.) and sequenced. The draft genome contains a large number of enzyme-encoding genes with predicted function against several complex polysaccharides found in the cell walls of algae.
Genome Sequence of
Bacillus cereus
Phage vB_BceS-MY192
Authors: Yang Yong , Zhan Li , Chen Jiancai , Zhang Yunyi , Sun Yi , Yang Zhangnv , Jiang Liping , Zhu Hanping , Zhang Yanjun , Lu Yiyu , Mei Lingling 
Published: April 2016

ABSTRACT

Bacillus cereus
is an opportunistic foodborne pathogen. The phage vB_BceS-MY192 was isolated from
B. cereus
192 in a cooked rice sample. The temperate phage belongs to the
Siphoviridae
family,
Caudovirales
order. Here we announce the phage genome sequence and its annotation, which may expand the understanding of
B. cereus
siphophages.
Preserved Activity of CD20-Specific Chimeric Antigen Receptor–Expressing T Cells in the Presence of Rituximab
Authors: Rufener Gregory A. , Press Oliver W. , Olsen Philip , Lee Sang Yun , Jensen Michael C. , Gopal Ajay K. , Pender Barbara , Budde Lihua E. , Rossow Jeffrey K. , Green Damian J. , Maloney David G. , Riddell Stanley R. , Till Brian G. 
Published: April 2016

Abstract
CD20 is an attractive immunotherapy target for B-cell non-Hodgkin lymphomas, and adoptive transfer of T cells genetically modified to express a chimeric antigen receptor (CAR) targeting CD20 is a promising strategy. A theoretical limitation is that residual serum rituximab might block CAR binding to CD20 and thereby impede T cell–mediated anti-lymphoma responses. The activity of CD20 CAR-modified T cells in the presence of various concentrations of rituximab was tested in vitro and in vivo. CAR-binding sites on CD20+ tumor cells were blocked by rituximab in a dose-dependent fashion, although at 37°C blockade was incomplete at concentrations up to 200 μg/mL. T cells with CD20 CARs also exhibited modest dose-dependent reductions in cytokine secretion and cytotoxicity, but not proliferation, against lymphoma cell lines. At rituximab concentrations of 100 μg/mL, CAR T cells retained ≥50% of baseline activity against targets with high CD20 expression, but were more strongly inhibited when target cells expressed low CD20. In a murine xenograft model using a rituximab-refractory lymphoma cell line, rituximab did not impair CAR T-cell activity, and tumors were eradicated in &gt;85% of mice. Clinical residual rituximab serum concentrations were measured in 103 lymphoma patients after rituximab therapy, with the median level found to be only 38 μg/mL (interquartile range, 19–72 μg/mL). Thus, despite modest functional impairment in vitro, the in vivo activity of CD20-targeted CAR T cells remains intact at clinically relevant levels of rituximab, making use of these T cells clinically feasible. Cancer Immunol Res; 4(6); 509–19. ©2016 AACR.
See related Spotlight by Sadelain, p. 473.
Aspectos da crítica literária de Machado de Assis
Authors: Betella Gabriela Kvacek 
Published: April 2016

Escrevendo sobre literatura, Machado de Assis discute alguns problemas de interesse para a investigação acerca das formas de representação literária num "país novo". O crítico abandona polêmicas e declarações ineficientes para analisar, por exemplo, as idéias estrangeiras importadas pelos intelectuais brasileiros do século XIX, as condições do meio literário e a função política do escritor.
Dietary comparison of coexisting barn owl (Tyto alba) and eagle owl (Bubo bubo) during consecutive breeding seasons
Authors: Milchev Boyan 
Published: April 2016

Coexistence of predator species often depends on behaviours or preferences that result in spatio-temporal reduction of competition. In this study, the diets of coexisting barn owls (Tyto alba) and eagle owls (Bubo bubo) in an agricultural landscape of SE Bulgaria were compared. White-toothed shrews (Crociduraspp.), voles (Microtusspp.) and mice (Musspp.) were the main prey of barn owl (86.3% by number, 81.2% by biomass) with significantly different frequencies in annual diets. The principle biomass (64.8 ± 6.2%) of the significantly different eagle owl annual diets comprised much heavier prey such as white-breasted hedgehog (Erinaceus roumanicus), European hare (Lepus europaeus) and non-passerine birds of wetlands and open habitats. The two owl species preferred and hunted on different prey size groups in the same territory, and this difference explained the low level of food competition (6.0 ± 3.6% diet overlap according to prey biomass). Voles were the only prey of the two owls with significantly different frequencies for the annual diets in intraspecies comparisons. The proportions of voles in both diets showed similar trends during the study. Eagle owl predation on barn owls was slightly affected by their coexisting breeding despite the high levels of food stress of eagle owl. These findings provide insight into how preying habits can predict successful coexistence of potentially competing predator species.
Does the Atlantic Multidecadal Oscillation Get Its Predictability from the Atlantic Meridional Overturning Circulation?
Authors: Trenary Laurie , DelSole Timothy 
Published: April 2016

Abstract
This paper investigates the predictive relation between the Atlantic multidecadal oscillation (AMO) and Atlantic meridional overturning circulation across different climate models. Three overturning patterns that are significantly coupled to the AMO on interannual time scales across all climate models are identified using a statistical optimization technique. Including these structures in an autoregressive model extends AMO predictability by 2–9 years, relative to an autoregressive model without these structures.
Food puzzles for cats
Authors: Dantas Leticia MS , Delgado Mikel M , Johnson Ingrid , Buffington CA Tony 
Published: April 2016

Practical relevance: Many pet cats are kept indoors for a variety of reasons (eg, safety, health, avoidance of wildlife predation) in conditions that are perhaps the least natural to them. Indoor housing has been associated with health issues, such as chronic lower urinary tract signs, and development of problem behaviors, which can cause weakening of the human–animal bond and lead to euthanasia of the cat. Environmental enrichment may mitigate the effects of these problems and one approach is to take advantage of cats’ natural instinct to work for their food. Aim: In this article we aim to equip veterinary professionals with the tools to assist clients in the use of food puzzles for their cats as a way to support feline physical health and emotional wellbeing. We outline different types of food puzzles, and explain how to introduce them to cats and how to troubleshoot challenges with their use. Evidence base: The effect of food puzzles on cats is a relatively new area of study, so as well as reviewing the existing empirical evidence, we provide case studies from our veterinary and behavioral practices showing health and behavioral benefits resulting from their use.
Thoracic dust exposure is associated with lung function decline in cement production workers
Authors: Nordby Karl-Christian , Notø Hilde , Eduard Wijnand , Skogstad Marit , Fell Anne Kristin , Thomassen Yngvar , Skare Øivind , Bergamaschi Antonio , Pietroiusti Antonio , Abderhalden Rolf , Kongerud Johny , Kjuus Helge 
Published: April 2016

We hypothesised that exposure to workplace aerosols may lead to lung function impairment among cement production workers.Our study included 4966 workers in 24 cement production plants. Based on 6111 thoracic aerosol samples and information from questionnaires we estimated arithmetic mean exposure levels by plant and job type. Dynamic lung volumes were assessed by repeated spirometry testing during a mean follow-up time of 3.5 years (range 0.7–4.6 years). The outcomes considered were yearly change of dynamic lung volumes divided by the standing height squared or percentage of predicted values. Statistical modelling was performed using mixed model regression. Individual exposure was classified into quintile levels limited at 0.09, 0.89, 1.56, 2.25, 3.36, and 14.6 mg·m−3, using the lowest quintile as the reference. Employees that worked in administration were included as a second comparison group.Exposure was associated with a reduction in forced expiratory volume in 1 s (FEV1), forced expiratory volume in 6 s and forced vital capacity. For FEV1% predicted a yearly excess decline of 0.84 percentage points was found in the highest exposure quintile compared with the lowest.Exposure at the higher levels found in this study may lead to a decline in dynamic lung volumes. Exposure reduction is therefore warranted.
Peacekeepers deserve more mental health research and care
Authors: Shigemura Jun , Nagamine Masanori , Harada Nahoko , Tanichi Masaaki , Shimizu Kunio , Yoshino Aihide 
Published: April 2016

SummaryUnited Nations peacekeeping personnel face numerous stressors due to their challenging deployments. Past studies have had inconsistent results regarding whether or not their deployment experience affects their mental health outcomes. Further studies are required to ascertain the associations between their outcomes and factors before, during and after their peacekeeping missions.
The Sounds of Desaturation: A Survey of Commercial Pulse Oximeter Sonifications
Authors: Loeb Robert G. , Brecknell Birgit , Sanderson Penelope M. 
Published: April 2016

BACKGROUND:
The pulse oximeter has been a standard of care medical monitor for >25 years. Most manufacturers include a variable-pitch pulse tone in their pulse oximeters. Research has shown that the acoustic properties of variable-pitch tones are not standardized. In this study, we surveyed the properties of pulse tones from 21 pulse oximeters, consisting of 1 to 4 instruments of 11 different models and 8 brands. Our goals were to fully document the sounds over saturation values 0% to 100%, test whether tones become quieter at low saturation values, and create a public repository of pulse oximeter recordings for future use.

METHODS:
A convenience sample of commercial pulse oximeters in use at one hospital was studied. Audiovisual recordings of each pulse oximeter’s display and sounds were taken while it monitored a simulator starting at a saturation of 100% and slowly decreasing in 1% steps until the saturation reached 0%. Recorded pulse tones were analyzed for spectral frequency and total power. Audio files for each pulse oximeter containing 100 pulse tones, one at every saturation value, were created for inclusion in the repository.

RESULTS:
Recordings containing 509 to 1053 pulse tones were made from the 21 pulse oximeters. Fundamental frequencies at 100% saturation ranged from 479 to 921 Hz, and fundamental frequencies at 1% saturation ranged from 38 to 404 Hz. The pulse tones from all but one model pulse oximeter contained harmonics. Pulse tone step sizes were linear in 6 models and logarithmic in 6 models. Only 6 pulse oximeter models decreased the pulse tone pitch at every decrease in saturation; all others decreased the pitch at only select saturation thresholds. Five pulse oximeter models stopped decreasing pitch altogether once the saturation reached a certain lower threshold. Pulse tone power (perceived as loudness) changed with saturation level for all pulse oximeters, increasing above baseline as saturation decreased from 100% and decreasing to levels below baseline at low saturation values.

CONCLUSIONS:
Current pulse oximeters use different techniques to address the competing goals of (1) using pitch steps that are large enough to be readily perceived, and (2) conveying saturation values from 0 to 100 within a limited range of sound frequencies. From a clinical perspective, 2 techniques for increasing perceivability (increasing the frequency range and using ratio step sizes) have no drawback, but 2 techniques (not changing pitch at every saturation change and using a lower saturation cutoff) do have potential clinical drawbacks. On the basis of our findings, we have made suggestions for clinicians and manufacturers.
A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects
Authors: Langellotti Simona , Romano Valentina , Romano Giulia , Klima Raffaella , Feiguin Fabian , Cragnaz Lucia , Romano Maurizio , Baralle Francisco E. 
Published: April 2016

ABSTRACT
Transactive response DNA-binding protein 43 kDa (TDP-43, also known as TBPH in Drosophila melanogaster and TARDBP in mammals) is the main protein component of the pathological inclusions observed in neurons of patients affected by different neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD). The number of studies investigating the molecular mechanisms underlying neurodegeneration is constantly growing; however, the role played by TDP-43 in disease onset and progression is still unclear. A fundamental shortcoming that hampers progress is the lack of animal models showing aggregation of TDP-43 without overexpression. In this manuscript, we have extended our cellular model of aggregation to a transgenic Drosophila line. Our fly model is not based on the overexpression of a wild-type TDP-43 transgene. By contrast, we engineered a construct that includes only the specific TDP-43 amino acid sequences necessary to trigger aggregate formation and capable of trapping endogenous Drosophila TDP-43 into a non-functional insoluble form. Importantly, the resulting recombinant product lacks functional RNA recognition motifs (RRMs) and, thus, does not have specific TDP-43-physiological functions (i.e. splicing regulation ability) that might affect the animal phenotype per se. This novel Drosophila model exhibits an evident degenerative phenotype with reduced lifespan and early locomotion defects. Additionally, we show that important proteins involved in neuromuscular junction function, such as syntaxin (SYX), decrease their levels as a consequence of TDP-43 loss of function implying that the degenerative phenotype is a consequence of TDP-43 sequestration into the aggregates. Our data lend further support to the role of TDP-43 loss-of-function in the pathogenesis of neurodegenerative disorders. The novel transgenic Drosophila model presented in this study will help to gain further insight into the molecular mechanisms underlying neurodegeneration and will provide a valuable system to test potential therapeutic agents to counteract disease.
Nafsika Mylona, Griechenlands Gedenkorte der Antike in der deutschsprachigen Reiseliteratur des 19. und 20.
Authors: Αντωνοπούλου Αναστασία 
Published: April 2016

Στο πλαίσιο της βιβλιοκρισίας παρουσιάζονται οι βασικές θέσεις της συγκριτολογικής μελέτης: Nafsika Mylona, Griechenlands Gedenkorte der Antike in der deutschsprachigen Reiseliteratur des 19. und 20. Jahrhunderts, Königshausen und Neumann, Würzburg 2014 (280 σελίδες) [Μνημειακοί τόποι της ελληνικής αρχαιότητας στη γερμανόφωνη ταξιδιωτική λογοτεχνία του 19ου και 20ού αιώνα]Πρόκειται για τη διδακτορική διατριβή της συγγραφέως η οποία έγινε δεκτή από τη Φιλοσοφική Σχολή του Πανεπιστημίου του Μονάχου το 2012 και εκδόθηκε το 2014 από τον εκδοτικό οίκο Königshausen und Neumann.
Review of Penelope Buckley's The Alexiad of Anna Komnene: Artistic Strategy in the Making of a Myth
Authors: Linardou Kallirroe 
Published: April 2016

Review of Penelope Buckley, <em>The Alexiad of Anna Komnene: Artistic Strategy in the Making of a Myth</em>, Cambridge: Cambridge University Press, 2014. xv + 318 pp.
Review of Ioannis D. Evrigenis' Αντίπαλον δέος: Έξωθεν φόβος και συλλογική δράση
Authors: Steiris Georgios 
Published: April 2016

<p>Review of Ioannis D. Evrigenis, <em>Αντίπαλον δέος: Έξωθεν φόβος και συλλογική δράση</em> [<em>Fear of Enemies and Collective Action</em>], Iraklio: Crete University Press, 2014. 448 pp.</p>
Σύνδεση σχολείου-οικογένειας και το ζήτημα της μεταξύ τους συνεργασίας: Kριτική παρουσίαση βασικών θεωρητικών μοντέλων
Authors: Πεντέρη Ευθυμία , Πετρογιάννης Κωνσταντίνος 
Published: April 2016

Η σχέση σχολείου-οικογένειας αποτελεί μια δυναμική διαδικασία με αναπτυξιακό χαρακτήρα που αντανακλά τις εκάστοτε κοινωνικές, πολιτικές, οικονομικές συνθήκες. Οι αντιλήψεις και αξίες που καθορίζουν τους ρόλους, τις αλληλεπιδράσεις και τους στόχους των δύο πλαισίων αναφορικά με την εκπαίδευση του παιδιού, καθορίζουν το πλαίσιο της μεταξύ τους σύγκλισης, δίνοντας διαφορετικό κάθε φορά νόημα και περιεχόμενο στον όρο <em>συνεργασία</em>. Διάφορες προσεγγίσεις, άλλες με περισσότερο θεωρητικό προσανατολισμό και άλλες με μεγαλύτερη εμπειρική ισχύ και τεκμηρίωση, έχουν κατά καιρούς προταθεί επιχειρώντας να αποτυπώσουν και να κωδικοποιήσουν τις διαστάσεις, τα επίπεδα και τις μορφές που μπορεί να πάρει αυτή η συνεργασία. Στόχος της παρούσας εργασίας είναι η συνοπτική, κριτική παρουσίαση ορισμένων βασικών θεωρητικών σχημάτων που αφορούν τη σύνδεση του σχολικού και του οικογενειακού πλαισίου και τα οποία συνοψίζουν τις εξελίξεις από το χώρο της εκπαιδευτικής και της ψυχολογικής έρευνας κυρίως από τα μέσα της δεκαετίας του 1990 μέχρι σήμερα. Τα έξι μοντέλα που παρουσιάζονται, επιλέχθηκαν με γνώμονα τη διαφορετική οπτική που παρουσιάζουν και τη συμβολή του καθενός ξεχωριστά αλλά και σε συνδυασμό, στην κατανόηση της σχέσης σχολείου και οικογένειας. Από την παρουσίαση προκύπτει ότι υπάρχει μια σχετική διάσταση στον τρόπο που γίνεται αντιληπτό το ζήτημα της συνεργασίας των δύο πλαισίων. Η ανάδειξη των διαφορών στην αντίληψη της συνεργασίας σχολείου-οικογένειας είναι σημαντική για την κατανόηση των μορφών που παίρνει αυτή η συνεργασία στην εκπαιδευτική πρακτική με στόχο το σχεδιασμό κατάλληλων και αποτελεσματικών πρακτικών από πλευράς σχολείου.