bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxicity, genotoxicity and mutagenicity of mixed ternary mononuclear Mg complex based on valproic acid with 1,10‐phenanthroline in Saccharomyces cerevisiae and V79 cells
Authors: Vanini Julia , Rodrigues Gabriel Berbigier , Juchem André Luiz Mendes , Guecheva Temenouga Nikolova , Moura Sidnei , Dumas Françoise , Henriques João Antonio Pêgas , de Oliveira Iuri Marques 
Published: October 2024

AbstractValproic acid (VA) is a widely used drug for the treatment of diseases affecting the central nervous system. Due to its epigenetic modulatory potential, it has been studied for possible therapeutic application in anticancer therapies. However, the VA exhibits different side effects in its application. Thus, synthetic coordination complexes with valproate can generate promising candidates for new active drugs with reduced toxicity. In this sense, we investigated the genotoxic and mutagenic potential of the sodium valproate and of the mixed ternary mononuclear Mg complex based on VA with 1,10‐phenanthroline (Phen) ligand ‐ [Mg (Valp)2Phen], in Saccharomyces cerevisiae and V79 cells. The MTT and clonal survival assays in V79 cells indicated that the Mg complex has higher cytotoxicity than sodium valproate. A similar cytotoxicity profile is observed in yeast. This fact is possibly due to the intercalation capacity of [Mg(Valp)2Phen], inducing DNA strand breaks, as observed in the comet assay and micronucleus test. In this sense, members of the NER, HR, NHEJ and TLS repair pathways are required for the repair of DNA lesions induced by [Mg(Valp)2Phen]. Interestingly, BER proteins apparently increase the cytotoxic potential of the drug. Furthermore, the [Mg(Valp)2Phen] showed higher cytotoxicity in V79 cells and yeast when compared to sodium valproate indicating applicability as a cytotoxic agent.
Efficacy and safety of olverembatinib in adult BCR::ABL1‐positive ALL with T315I mutation or relapsed/refractory disease
Authors: Liu Weiyang , Wang Cheng , Ouyang Wanyan , Hao Jie , Ren Jiayi , Peng Lijun , Tang Sijie , Liu Yuanfang , Zhu Yongmei , Weng Xiangqin , Jing Duohui , Chen Saijuan , Wang Jin , Mi Jian‐Qing 
Published: October 2024

SummaryThird‐generation tyrosine kinase inhibitors (TKIs) have much potential for the treatment of BCR::ABL1‐positive leukaemia, particularly that harbouring the ABL1 T315I mutation. Olverembatinib (HQP1351), a novel third‐generation TKI, has favourable efficacy and safety profiles in chronic myeloid leukaemia. Here, we present the clinical findings from 31 BCR::ABL1‐positive acute lymphoblastic leukaemia (ALL) patients who received olverembatinib. Among the 14 patients with overt relapsed/refractory (R/R) disease (including 10 with the T315I mutation), 71.4% achieved an overall response. Of the other 17 patients with minimal residual disease (MRD)‐positive ALL (including 14 with the T315I mutation), 60.0% and 47.1% achieved MRD flow negativity and complete molecular remission, respectively. With a median follow‐up time of 16.3 months, the median event‐free survival and overall survival were 3.9 and 8.3 months respectively, in overt R/R patients, and 11.5 and 18.4 months in MRD‐positive patients. Allogeneic haematopoietic stem cell transplantation further improved outcomes among responders. The safety profile was generally manageable. This study suggests that olverembatinib‐based therapy is another promising option for BCR::ABL1‐positive ALL in addition to ponatinib, especially for patients with MRD‐positive disease and a single T315I mutation.
Minimum or Living Wage? Framing Effects on Preferences and Expectations
Authors: Schaitberger Tim 
Published: October 2024

ABSTRACTLiving wage campaigns are widely studied, yet less is known about how the frame differs from the minimum wage regarding public opinion and preferences. Such framing effects hold policy implications, as in 2016, UK Government changed the name of the regulatory wage floor to a living wage, concurrent with calls for welfare benefits cuts. This study explores how using the frame of ‘living’ rather than ‘minimum’ wage changes public socioeconomic expectations and preferences, and examines how a proposed wage increase, ranging from 50p to £6, comparatively influences public support for welfare spending. Methodologically, a sample from the United Kingdom's general population was recruited to participate in a series of online survey experiments. Treatment frames were randomly administered, followed by questions regarding the regulatory wage floor, and socioeconomic and redistributive preferences. Findings suggest introducing the term ‘living wage’ results in (1) higher expected real wages and unemployment effects; (2) raises the preferred wage floor for the United Kingdom and London; (3) greater desire for separate regional wage floors and (4) modest evidence suggesting that a living wage frame increases support for welfare spending. Interestingly, a proposed monetary wage floor increase had a null effect on welfare preferences when calling for a low or modest increase. However, a substantial proposed increase of over 50% led to a sharp reduction in support for benefits spending.
The liver fibrosis‐8 index is a predictor for all‐cause mortality in cardiovascular disease patients: A cohort study
Authors: Yang Xian , Wang Jiaxin , Zhang Xiaofang , Wu Liangyan , Wang Ruxin , Lu Jianrong , Wang Lihong 
Published: October 2024

AbstractAimsParticipants with cardiovascular diseases (CVD) often exhibit liver function abnormalities, hepatic fibrosis and cirrhosis. The extent of liver fibrosis is closely related to the prognosis of CVD. However, the association between the liver fibrosis‐8 (FIB‐8) index, a marker of liver fibrosis, and all‐cause mortality in CVD participants remains unclear. This study aims to investigate the relationship between the FIB‐8 index and all‐cause mortality among individuals with CVD.Materials and MethodsA total of 1727 CVD American participants were enrolled from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. Initially, we constructed weighted COX regression models and performed sensitivity analyses to examine the correlation between the FIB‐8 index and all‐cause mortality in CVD participants. Subsequently, we employed restricted cubic spline (RCS) to visualize their linear relationship. Finally, the stratified analyses and interaction tests of covariates were performed and presented in the forest plot.ResultsA total of 1727 participants were included in our study, with a mean age of 61.68 ± 0.47 years, with men accounting for 59.19%. After adjustment for relevant covariables, weighted COX regression models indicated that the hazard ratio (HR) and 95% confidence interval (95% CI) for the association between the FIB‐8 index and all‐cause mortality in CVD participants was 1.21 (1.12, 1.30). Sensitivity analysis was then conducted, revealing that the results remained stable. In fully adjusted model, individuals in quartiles 3 and 4 demonstrated significant statistical differences compared to the lowest FIB‐8 index quartile, with HR (95% CI) values of 1.88 (1.23, 2.87) and 2.17 (1.33, 3.53), respectively. Subsequently, RCS showed a linear relationship between the FIB‐8 index and all‐cause mortality among CVD participants. Finally, the interaction test revealed that no other covariables had significant interactions with the FIB‐8 index in this study.ConclusionsA positive and linear correlation was observed between the FIB‐8 index and all‐cause mortality among CVD adult participants in NHANES from 1999 to 2018. Our findings indicated that the FIB‐8 index could serve as an excellent indicator for assessing all‐cause mortality within the CVD population. The lower the FIB‐8 index, the lower the all‐cause mortality among CVD participants.
Individual and combined effects of muscle strength and visceral adiposity on incident prediabetes and type 2 diabetes in a longitudinal cohort of midlife Asian women
Authors: Wong Beverly W. X. , Tan Darren Y. Z. , Li Ling‐Jun , Yong Eu‐Leong 
Published: October 2024

AbstractAimTo investigate the independent and combined effects of muscle strength and visceral adiposity on prediabetes and type 2 diabetes incidence among midlife women.Materials and MethodsIn this prospective study of midlife women (mean age 56.4 years), visceral adiposity, defined as visceral adipose tissue (VAT) >131 cm2 measured by dual energy X‐ray absorptiometry, and poor combined muscle strength, defined as handgrip strength <18 kg and/or five‐time repeated chair stand test performance ≥12 s, were determined at baseline between 2014 and 2016. After 6.6 years, the effects of VAT and muscle strength on risk of incident prediabetes (fasting blood glucose 5.6–6.9 mmol/L) and type 2 diabetes (fasting blood glucose levels ≥7 mmol/L, medication use, or physician diagnosis) were examined using modified Poisson regression analysis.ResultsAmong the 733 initially normoglycaemic participants, 150 (20.5%) developed prediabetes or type 2 diabetes. Women with both poor combined muscle strength and high VAT had the highest risk for both prediabetes and type 2 diabetes (adjusted relative risk [aRR] 2.63, 95% confidence interval [CI] 1.81–3.82). In comparison, high VAT alone increased risk by 1.78‐fold (95% CI 1.12–2.84). Stratification analyses showed that among women with low muscle strength, high VAT demonstrated increased risks of prediabetes and type 2 diabetes (aRR 2.84, 95% CI 1.95–4.14) compared to those with normal strength (aRR 1.66, 95% CI 1.04–2.65).ConclusionsLow combined muscle strength with high VAT poses a greater risk for the development of prediabetes and type 2 diabetes than high VAT alone. Muscle strengthening should be promoted alongside weight loss in diabetes prevention.
Destisol: A decision‐support tool to assess the ecosystem services provided by urban soils for better urban planning
Authors: Séré Geoffroy , Lothode Maïwenn , Blanchart Anne , Chirol Clémentine , Tribotte Antoine , Schwartz Christophe 
Published: October 2024

AbstractUrban soils exhibit a wide diversity of properties that have no equivalent in other environments but are overwhelmingly perceived as degraded by decision makers. As a result, their potential is not considered in urban planning even though they can deliver a range of ecosystem services. This paper describes a decision support tool for assessing soil ecosystem services to support urban land use planning. An overview of existing methods for assessing ecosystem services provided by urban soils has been detailed. Destisol, a model developed specifically for the urban context, is presented in detail. Destisol was then applied to 37 urban soils under various situations and pedoclimates. The main innovations of Destisol lie in the consideration of soil properties throughout the whole pedon and in the evaluation of the compatibility of the soil with different land covers. It is based on the acquisition of soil indicators, which are transformed into scores of soil functions, then into compatible land covers and finally into scores of ecosystem services. The architecture of the model is based on 20 physico‐chemical‐biological soil indicators used to score 15 soil functions, based on a detailed set of decision rules. The soil functions scores allow the calculation of a percentage of compatibility for 13 land covers. Finally, the resulting scores are used to evaluate 18 ecosystem services, as a function of land cover. The tests show a wide distribution of scores depending on the soil studied, but also depending on the soil function, land cover or ecosystem service considered. Technosols show the largest dispersion of soil function scores, and no correlation was found between the anthropization gradient and the mean soil function score. The main results of Destisol are an assessment of the soil suitability, that is the compatibility between a soil and a land cover, and an explicit assessment of the ecosystem services provided depending on the land covers.
Immune triggers preceding neuralgic amyotrophy
Authors: Sparasci Davide , Schilg‐Hafer Lenka , Schreiner Bettina , Scheidegger Olivier , Peyer Anne‐Kathrin , Lascano Agustina Maria , Vicino Alex , Décard Bernhard Friedrich , Tsouni Pinelopi , Humm Andrea Monika , Pianezzi Enea , Zezza Giulia , Hundsberger Thomas , Dietmann Anelia , Jung Hans H. , Kuntzer Thierry , Wilder‐Smith Einar , Martinetti‐Lucchini Gladys , Petrini Orlando , Fontana Stefano , Gowland Peter , Niederhauser Christoph , Gobbi Claudio , Ripellino Paolo 
Published: October 2024

AbstractBackground and purposeInfections and vaccinations have been identified as potential immunological triggers of neuralgic amyotrophy (NA), but the exact type and frequency of the preceding agents is unknown.MethodsThis was a multicentre, prospective, observational, matched case–control study. NA was diagnosed by neuromuscular experts according to validated clinical criteria and electrodiagnostic studies. Clinical data and biological samples of NA patients were collected within 90 days from disease onset between June 2018 and December 2023. All NA patients were asked about prior infection and vaccination in the month before disease onset. Serological tests for hepatitis E virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Epstein–Barr virus, cytomegalovirus, parvovirus B19, varicella‐zoster virus, Borrelia burgdorferi, Mycoplasma pneumoniae and Bartonella henselae were performed in a central laboratory. Each case was matched with a healthy control for age, sex, place of residence and time of blood collection.ResultsFifty‐seven patients and corresponding controls were included. The mean age was 45 years for both groups. NA onset was preceded by a symptomatic infectious trigger confirmed by microbiological tests in 15/57 (26.3%) patients. Coronavirus disease 2019 vaccination was considered a potential trigger in 7/57 (12.3%) subjects. An acute viral infection was associated with a bilateral involvement of the brachial plexus (p = 0.003, Cramèr's V = 0.43).ConclusionsConfirmed immune triggers (infection or vaccination) preceded disease onset in 22/57 (38.6%) NA cases. We suggest to test NA patients in the acute phase for intracellular antigens, especially in the case of concomitant bilateral involvement and hepatitis.
Responding to the unacknowledged trauma and disenfranchised grief in infant adoption
Authors: Haralambie Ann M. 
Published: October 2024

AbstractRecently, there has been more attention paid to trauma related to adoption. This article addresses the unacknowledged trauma which may exist with children adopted in infancy, before they had any retrievable recollection of their first families. Because this trauma has not been recognized, there has been inadequate attention paid to the adoptee's grief at the loss of the first family. This article suggests that all sealed records laws which prevent adoptees from having access to records otherwise available to non‐adoptees be repealed, that all adoptions be presumed to be open, with the possibility for ongoing contact with first family members, and that more trauma‐informed and adoption‐competent therapeutic resources be made available to adoptees.
Does political corruption reduce pro‐social behavior by bureaucrats? Lab experimental evidence from Bangladesh
Authors: Woodhouse Eleanor Florence , Meyer‐Sahling Jan‐Hinrik , Mikkelsen Kim Sass , Schuster Christian , Islam Kazi Maruful , Rahman Taiabur 
Published: October 2024

AbstractNumerous studies assess how politicians control and shape bureaucracy. Yet, how politicians' behavior affects the norms and behaviors of bureaucrats through role modeling has not been studied. This is a curious omission, in light of evidence that social norms shape bureaucratic behavior. Through a lab experiment with over 900 bureaucrats in Bangladesh, we explore whether political corruption affects bureaucrats' pro‐social behavior and whether this effect is particularly pronounced for corruption of the current government, as a particularly relevant social norm referent. Using a political corruption prime, we present evidence that those bureaucrats who recall episodes of the current government's political corruption when prompted to think about political corruption donate significantly lower real monetary amounts to charity. By contrast, we do not find clear effects of political corruption by other actors. Our findings underscore the importance of political leaders as role models for bureaucrats and the damage that political corruption may inflict on pro‐social behavior in bureaucracies.
The effectiveness of parenteral agents to mitigate relapses after severe acute migraine headache presentations: A systematic review and network analysis
Authors: Kirkland Scott , Meyer Jillian , Visser Lloyd , Campbell Sandra , Villa‐Roel Cristina , Friedman Benjamin W. , Essel Nana Owusu , Rowe Brian H. 
Published: October 2024

AbstractObjectivesTo compare the effectiveness of parenteral agents to reduce relapse in patients with acute migraine and identify factors that predict relapse.BackgroundFollowing discharge from emergency settings, many patients with acute migraine will experience a relapse in pain; severe relapses may result in re‐visits to emergency settings.MethodsA comprehensive literature search, updated to 2023, was conducted to identify randomized controlled trials assessing the effectiveness of parenteral agents on relapse outcomes in patients with acute migraine discharged from emergency settings. Two independent reviewers completed study selection, quality assessment, and data extraction. A traditional meta‐analysis compared parenteral corticosteroids to placebo; a frequentist network analysis assessed direct and indirect comparisons. Results are reported as risk ratios (RRs) and 95% confidence intervals (CIs). The review protocol was registered with the International Prospective Register of Systematic Reviews (identifier: CRD42018099493).ResultsFrom 8949 citations, a total of 53 unique studies were included involving 6167 patients. Most studies had a high or unclear risk of bias. Corticosteroids significantly reduced relapses compared to placebo (RR 0.67, 95% CI 0.52–0.88; I2 = 0%). Patients receiving lidocaine (RR 0.10, 95% CI 0.01–0.82), sedatives/hypnotics (RR 0.33, 95% CI 0.14–0.75), ergot agents (RR 0.44, 95% CI 0.25–0.75), neuroleptics (RR 0.47, 95% CI 0.31–0.71), opioids (RR 0.58; 95% CI 0.35–0.94), or corticosteroids (RR 0.64, 95% CI 0.47–0.86) were significantly less likely to relapse. Lidocaine (RR 0.09, 95% CI 0.01–0.71), combination therapy (RR 0.12, 95% CI 0.02–0.74), or adding corticosteroids (RR 0.61, 95% CI 0.44–0.84) were more likely to reduce severe relapses. Longer duration of headache and residual pain at discharge were significantly associated with higher relapses.DiscussionCorticosteroids remain the recommended first‐line option to reduce relapse outcomes. Some parenteral agents typically provided for pain relief including ergot agents, neuroleptics, or combination therapy may effectively reduce relapse; however, opioids are not recommended due to safety concerns. Additional research is needed for some lesser studied, albeit promising, agents including lidocaine and propofol. Effective pain control in emergency settings prior to discharge and duration of headache may play a role in the success of such treatments and further investigations could provide further insight regarding how and why some parenteral agents are effective in mitigating relapse events.
Geochemical Signatures of Igneous Zircon and Apatite: Generation of Archean TTGs in the Barberton Granitoid‐Greenstone Terrain, South Africa
Authors: Miyake Shiho , Aoki Kazumasa , Komiya Tsuyoshi , Aoki Shogo , Fukuyama Mayuko , Ogasawara Masatsugu 
Published: October 2024

ABSTRACTWe performed isotopic and trace element analyses of zircons and apatites from the Inyoni, Batavia, and Badplaas tonalites, trondhjemites and granodiorites series (TTG) in the Barberton Granitoid‐Greenstone Terrain (BGGT), South Africa using laser‐ablation inductively‐coupled plasma‐mass spectrometry to investigate Archean tectono‐magmatism. The U–Pb ages obtained from these minerals are consistent with previously reported ages ranging from ca. 3.28 to 3.23 Ga. The chondrite‐normalized REE patterns of zircons and apatites enabled us to identify grains with primary information on TTG magmatism. Trace element characteristics, such as Sr/Y and Ti concentrations from primary grains, indicated that Inyoni TTG magmas coexisted with eclogite residue, whereas Badplaas and Batavia TTG magmas coexisted with garnet‐amphibolite residue during the early formation stages. Furthermore, Lu–Hf isotope data, combined with the U/Yb‐Nb/Yb data from zircons, suggested that the tectonic settings for TTG generation involved a subduction‐type environment accompanied by crustal reworking. This implies that horizontal plate movement played a significant role in the TTG tectono‐magmatism, and the subduction of old and cold plates facilitated slab melting under eclogite facies conditions, leading to TTG generation on the Archean Earth.
Effectiveness of surgical interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline
Authors: Oei Krista , Johnston Bradley C. , Ball Geoff D. C. , Fitzpatrick‐Lewis Donna , Usman Ali , Sherifali Diana , Esmaeilinezhad Zahra , Merdad Roah , Dettmer Elizabeth , Erdstein Julius , Langer Jacob C. , Birken Catherine , Henderson Mélanie , Moore Sarah A. , Morrison Katherine M. , Hamilton Jill ,   the Steering Committee for Updating the Canadian Clinical Practice Guideline for Managing Pediatric Obesity
Published: October 2024

SummaryObjectiveTo summarize the literature on bariatric surgery for managing pediatric obesity, including intervention effects to improve patient‐reported outcome measures (PROMs), cardiometabolic risk factors, anthropometry, and assess adverse events (AEs).MethodsEligible studies were published between January 2012 and January 2022 and included randomized controlled trials (RCTs) and observational (controlled and uncontrolled) studies before and after surgery with a mean age <18 years old. Outcomes and subgroups were selected a priori by stakeholders; estimates of effect for outcomes were presented relative to minimal important differences (MIDs) and GRADE certainty of evidence. We examined data on PROMs, cardiometabolic risk factors, anthropometry, and AEs. Subgroup analyses examined outcomes by follow‐up duration and surgical technique, when possible.ResultsOverall, 63 publications (43 original studies) met our inclusion criteria (n = 6128 participants; 66% female). Studies reported six different surgical techniques that were evaluated using uncontrolled single arm observational (n = 49), controlled observational (n = 13), and RCT (n = 1) designs. Most studies included short‐term follow‐up (<18 months) only. PROMs were measured in 12 (28%) studies. Surgery led to large improvements in health‐related quality of life compared to baseline and control groups, and moderate to very large improvements in cardiometabolic risk factors compared to baseline. Large to very large improvements in BMIz were noted compared to baseline across all follow‐up periods. There was limited evidence of AEs with most reporting mild or non‐specific AEs; serious AEs were uncommon.ConclusionBariatric surgery demonstrated primarily moderate to very large improvements across diverse outcomes with limited evidence of AEs, albeit with low to moderate certainty of evidence.