bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naming Rites for Naming Wrongs: What We Talk about When We Talk about Woodrow Wilson
Authors: Strolovitch Dara Z. , Crowder Chaya Y. 
Published: August 2016

Woodrow Wilson is the only American political scientist to have served as President of the United States. In the time between his political science Ph.D. (from Johns Hopkins, in 1886) and his tenure as president (1913–21), he also served as president of Princeton University (1902–10) and president of the American Political Science Association (1909–10). Wilson is one of the most revered figures in American political thought and in American political science. The Woodrow Wilson Award is perhaps APSA’s most distinguished award, given annually for the best book on government, politics, or international affairs published in the previous year, and sponsored by the Woodrow Wilson Foundation at Princeton University.Wilson has also recently become the subject of controversy, on the campus of Princeton University, and in the political culture more generally, in connection with racist statements that he made and the segregationist practices of his administration. A group of Princeton students associated with the “Black Lives Matter” movement has demanded that Wilson’s name be removed from two campus buildings, one of which is the famous Woodrow Wilson School of Public and International Affairs (see Martha A. Sandweiss, “Woodrow Wilson, Princeton, and the Complex Landscape of Race,”http://www.thenation.com/article/woodrow-wilson-princeton-and-the-complex-landscape-of-race/). Many others have resisted this idea, noting that Wilson is indeed an important figure in the history of twentieth-century liberalism and Progressivism in the United States.A number of colleagues have contacted me suggesting thatPerspectivesought to organize a symposium on the Wilson controversy. Although we do not regularly organize symposia around current events, given the valence of the controversy and its connection to issues we have featured in our journal (see especially the September 2015 issue on “The American Politics of Policing and Incarceration”), and given Wilson's importance in the history of our discipline, we have decided to make an exception in this case. We have thus invited a wide range of colleagues whose views on this issue will interest our readers to comment on this controversy. —Jeffrey C. Isaac, Editor.
Education and Transparency: Changes in Campus Iconography
Authors: Pinderhughes Dianne 
Published: August 2016

Woodrow Wilson is the only American political scientist to have served as President of the United States. In the time between his political science Ph.D. (from Johns Hopkins, in 1886) and his tenure as president (1913–21), he also served as president of Princeton University (1902–10) and president of the American Political Science Association (1909–10). Wilson is one of the most revered figures in American political thought and in American political science. The Woodrow Wilson Award is perhaps APSA’s most distinguished award, given annually for the best book on government, politics, or international affairs published in the previous year, and sponsored by the Woodrow Wilson Foundation at Princeton University.Wilson has also recently become the subject of controversy, on the campus of Princeton University, and in the political culture more generally, in connection with racist statements that he made and the segregationist practices of his administration. A group of Princeton students associated with the “Black Lives Matter” movement has demanded that Wilson’s name be removed from two campus buildings, one of which is the famous Woodrow Wilson School of Public and International Affairs (see Martha A. Sandweiss, “Woodrow Wilson, Princeton, and the Complex Landscape of Race,” http://www.thenation.com/article/woodrow-wilson-princeton-and-the-complex-landscape-of-race/). Many others have resisted this idea, noting that Wilson is indeed an important figure in the history of twentieth-century liberalism and Progressivism in the United States.A number of colleagues have contacted me suggesting that Perspectives ought to organize a symposium on the Wilson controversy. Although we do not regularly organize symposia around current events, given the valence of the controversy and its connection to issues we have featured in our journal (see especially the September 2015 issue on “The American Politics of Policing and Incarceration”), and given Wilson's importance in the history of our discipline, we have decided to make an exception in this case. We have thus invited a wide range of colleagues whose views on this issue will interest our readers to comment on this controversy. —Jeffrey C. Isaac, Editor.
Transforming Silence into an Active, Present Awareness: What to do about Wilson’s Legacy
Authors: Shaw Todd 
Published: August 2016

Woodrow Wilson is the only American political scientist to have served as President of the United States. In the time between his political science Ph.D. (from Johns Hopkins, in 1886) and his tenure as president (1913–21), he also served as president of Princeton University (1902–10) and president of the American Political Science Association (1909–10). Wilson is one of the most revered figures in American political thought and in American political science. The Woodrow Wilson Award is perhaps APSA’s most distinguished award, given annually for the best book on government, politics, or international affairs published in the previous year, and sponsored by the Woodrow Wilson Foundation at Princeton University.Wilson has also recently become the subject of controversy, on the campus of Princeton University, and in the political culture more generally, in connection with racist statements that he made and the segregationist practices of his administration. A group of Princeton students associated with the “Black Lives Matter” movement has demanded that Wilson’s name be removed from two campus buildings, one of which is the famous Woodrow Wilson School of Public and International Affairs (see Martha A. Sandweiss, “Woodrow Wilson, Princeton, and the Complex Landscape of Race,” http://www.thenation.com/article/woodrow-wilson-princeton-and-the-complex-landscape-of-race/). Many others have resisted this idea, noting that Wilson is indeed an important figure in the history of twentieth-century liberalism and Progressivism in the United States.A number of colleagues have contacted me suggesting that Perspectives ought to organize a symposium on the Wilson controversy. Although we do not regularly organize symposia around current events, given the valence of the controversy and its connection to issues we have featured in our journal (see especially the September 2015 issue on “The American Politics of Policing and Incarceration”), and given Wilson's importance in the history of our discipline, we have decided to make an exception in this case. We have thus invited a wide range of colleagues whose views on this issue will interest our readers to comment on this controversy. —Jeffrey C. Isaac, Editor.
Municipal solid waste composting: Application as a tomato fertilizer and its effect on crop yield, fruit quality and phenolic content
Authors: Ribas-Agustí Albert , Seda Marta , Sarraga Carmen , Montero Juan I. , Castellari Massimo , Muñoz Pere 
Published: August 2016

AbstractComposting is an appealing way to reutilize the organic fraction of municipal solid waste (MSW). Beyond the obvious advantage of reducing urban waste, the use of MSW compost in agriculture entails other potential benefits, such as reducing the amount of mineral fertilizer applied to the field and providing a potentially higher quality alternative. However, some concerns may arise from its use, such as crop yield and quality alterations. This work studied the effect of fertilizing with compost obtained from the organic fraction of MSW, on crop yield, crop quality and phenolic content of tomato fruit. Experiments were conducted in the Barcelona area, usingSolanum lycopersicumL., var. ‘Penjar’, a popular regional tomato. Compared with the use of mineral fertilizer (M), fertilization with MSW compost alone (C) or combined with mineral fertilizer (C + M) had no significant effect on tomato fruit quality characterized by weight, diameter or Brix, nor was there a significant effect on total phenolic content. In contrast, the C treatment altered the phenolic profile by enhancing a kaempferol derivative, and caused a 43 and 48% yield reduction compared with the C + M and M treatments, respectively. Overall, composted MSW + mineral fertilizer appeared to be the best strategy for the reutilization of MSW in tomato culture, as it did not compromise crop yield or fruit quality.
An Overview of Sri Lanka’s Bilateral Investment Treaties: Status Quo and Some Insights into Future Modifications
Authors: PATHIRANA Dilini 
Published: August 2016

AbstractSri Lanka is the first country against which a foreign investor has had recourse to international arbitration based on the dispute settlement clause in a bilateral investment treaty (BIT). This was the case ofAAPL v. Sri Lanka.Since then, the country has been challenged twice before the International Centre for Settlement of Investment Disputes (ICSID), while its latest encounter was in the case ofDeutsche Bank AG v. Sri Lanka. In the intervening years between these two cases, Sri Lanka maintained silence and failed to alter its BITs in a global context where the conventional attitude on international investment agreements (IIAs) is being increasingly reconsidered. This paper provides an overview of Sri Lanka’s BITs, which highlights the urgency of reconsidering the country’s investment treaty-making practice. It suggests some modifications to align the country’s investment treaty-making practice with international investment law (IIL) developments.
Commodity Flows, Diaspora Networking, and Contested Agency in the Eastern Indian Ocean c. 1000–1500
Authors: Hall Kenneth R. 
Published: August 2016

AbstractRecent revisionist approaches to early pre-1500 eastern Indian Ocean history draw from and cross-reference epigraphic, archaeological, art historical, literary, cultural, textual, shipwreck, and a variety of other primary and secondary sources as these document the evolution of Southeast Asia from roughly 300 to 1500, before significant European regional presence became a factor. This study's focus is the transitional importance of c. 1000–1500 Indian Ocean international maritime trade and transit from the South Asian shorelines of the Bay of Bengal to the South China and Java Seas, which is conceived to have temporarily produced an inclusive eastern Indian Ocean zone of contact. In this then ‘borderless’ region there were a variety of meaningful contacts and material, cultural, and knowledge transfers that resulted in synthesis of Indian, Chinese, Middle Eastern, and Southeast Asian cultures and populations made possible by enhanced international maritime trade connections before European presence became a factor, a period often dated from the fall of Melaka to the Portuguese in 1511.
Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain
Authors: Wang Yu-Chuan , Chin Ko-Hsin , Tu Zhi-Le , He Jin , Jones Christopher J. , Sanchez David Zamorano , Yildiz Fitnat H. , Galperin Michael Y. , Chou Shan-Ho 
Published: August 2016

AbstractC-di-GMP is a bacterial second messenger regulating various cellular functions. Many bacteria contain c-di-GMP-metabolizing enzymes but lack known c-di-GMP receptors. Recently, two MshE-type ATPases associated with bacterial type II secretion system and type IV pilus formation were shown to specifically bind c-di-GMP. Here we report crystal structure of the MshE N-terminal domain (MshEN1-145) from Vibrio cholerae in complex with c-di-GMP at a 1.37 Å resolution. This structure reveals a unique c-di-GMP-binding mode, featuring a tandem array of two highly conserved binding motifs, each comprising a 24-residue sequence RLGxx(L/V/I)(L/V/I)xxG(L/V/I)(L/V/I)xxxxLxxxLxxQ that binds half of the c-di-GMP molecule, primarily through hydrophobic interactions. Mutating these highly conserved residues markedly reduces c-di-GMP binding and biofilm formation by V. cholerae. This c-di-GMP-binding motif is present in diverse bacterial proteins exhibiting binding affinities ranging from 0.5 μM to as low as 14 nM. The MshEN domain contains the longest nucleotide-binding motif reported to date.
TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma
Authors: Jung Joonil , Lee Joon Sang , Dickson Mark A. , Schwartz Gary K. , Le Cesne Axel , Varga Andrea , Bahleda Rastilav , Wagner Andrew J. , Choy Edwin , de Jonge Maja J. , Light Madelyn , Rowley Steve , Macé Sandrine , Watters James 
Published: August 2016

AbstractIn tumours that harbour wild-type p53, p53 protein function is frequently disabled by the mouse double minute 2 protein (MDM2, or HDM2 in humans). Multiple HDM2 antagonists are currently in clinical development. Preclinical data indicate that TP53 mutations are a possible mechanism of acquired resistance to HDM2 inhibition; however, this resistance mechanism has not been reported in patients. Utilizing liquid biopsies, here we demonstrate that TP53 mutations appear in circulating cell-free DNA obtained from patients with de-differentiated liposarcoma being treated with an inhibitor of the HDM2–p53 interaction (SAR405838). TP53 mutation burden increases over time and correlates with change in tumour size, likely representing selection of TP53 mutant clones resistant to HDM2 inhibition. These results provide the first clinical demonstration of the emergence of TP53 mutations in response to an HDM2 antagonist and have significant implications for the clinical development of this class of molecules.
Large polarization-dependent exciton optical Stark effect in lead iodide perovskites
Authors: Yang Ye , Yang Mengjin , Zhu Kai , Johnson Justin C. , Berry Joseph J. , van de Lagemaat Jao , Beard Matthew C. 
Published: August 2016

AbstractA strong interaction of a semiconductor with a below-bandgap laser pulse causes a blue-shift of the bandgap transition energy, known as the optical Stark effect. The energy shift persists only during the pulse duration with an instantaneous response time. The optical Stark effect has practical relevance for applications, including quantum information processing and communication, and passively mode-locked femtosecond lasers. Here we demonstrate that solution-processable lead-halide perovskites exhibit a large optical Stark effect that is easily resolved at room temperature resulting from the sharp excitonic feature near the bandedge. We also demonstrate that a polarized pump pulse selectively shifts one spin state producing a spin splitting of the degenerate excitonic states. Such selective spin manipulation is an important prerequisite for spintronic applications. Our result implies that such hybrid semiconductors may have great potential for optoelectronic applications beyond photovoltaics.
Refuting the hypothesis that the acquisition of germ plasm accelerates animal evolution
Authors: Whittle Carrie A. , Extavour Cassandra G. 
Published: August 2016

AbstractPrimordial germ cells (PGCs) give rise to the germ line in animals. PGCs are specified during embryogenesis either by an ancestral mechanism of cell–cell signalling (induction) or by a derived mechanism of maternally provided germ plasm (preformation). Recently, a hypothesis was set forth purporting that germ plasm liberates selective constraint and accelerates an organism’s protein sequence evolution, especially for genes from early developmental stages, thereby leading to animal species radiations; empirical validation has been claimed in vertebrates. Here we present findings from global rates of protein evolution in vertebrates and invertebrates refuting this hypothesis. Contrary to assertions of the hypothesis, we find no effect of preformation on protein sequence evolution, the evolutionary rates of early-stage developmental genes, or on species diversification. We conclude that the hypothesis is mechanistically implausible, and our multi-faceted analysis shows no empirical support for any of its predictions.
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
Authors: Nagarajan Arvindhan , Petersen Max C. , Nasiri Ali R. , Butrico Gina , Fung Annie , Ruan Hai-Bin , Kursawe Romy , Caprio Sonia , Thibodeau Jacques , Bourgeois-Daigneault Marie-Claude , Sun Lisha , Gao Guangping , Bhanot Sanjay , Jurczak Michael J. , Green Michael R. , Shulman Gerald I. , Wajapeyee Narendra 
Published: August 2016

AbstractInsulin resistance is a key driver of type 2 diabetes (T2D) and is characterized by defective insulin receptor (INSR) signalling. Although surface INSR downregulation is a well-established contributor to insulin resistance, the underlying molecular mechanisms remain obscure. Here we show that the E3 ubiquitin ligase MARCH1 impairs cellular insulin action by degrading cell surface INSR. Using a large-scale RNA interference screen, we identify MARCH1 as a negative regulator of INSR signalling. March1 loss-of-function enhances, and March1 overexpression impairs, hepatic insulin sensitivity in mice. MARCH1 ubiquitinates INSR to decrease cell surface INSR levels, but unlike other INSR ubiquitin ligases, MARCH1 acts in the basal state rather than after insulin stimulation. Thus, MARCH1 may help set the basal gain of insulin signalling. MARCH1 expression is increased in white adipose tissue of obese humans, suggesting that MARCH1 contributes to the pathophysiology of T2D and could be a new therapeutic target.
Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
Authors: Fan Zhichao , McArdle Sara , Marki Alex , Mikulski Zbigniew , Gutierrez Edgar , Engelhardt Britta , Deutsch Urban , Ginsberg Mark , Groisman Alex , Ley Klaus 
Published: August 2016

AbstractNeutrophils are essential for innate immunity and inflammation and many neutrophil functions are β2 integrin-dependent. Integrins can extend (E+) and acquire a high-affinity conformation with an ‘open’ headpiece (H+). The canonical switchblade model of integrin activation proposes that the E+ conformation precedes H+, and the two are believed to be structurally linked. Here we show, using high-resolution quantitative dynamic footprinting (qDF) microscopy combined with a homogenous conformation-reporter binding assay in a microfluidic device, that a substantial fraction of β2 integrins on human neutrophils acquire an unexpected E−H+ conformation. E−H+ β2 integrins bind intercellular adhesion molecules (ICAMs) in cis, which inhibits leukocyte adhesion in vitro and in vivo. This endogenous anti-inflammatory mechanism inhibits neutrophil aggregation, accumulation and inflammation.
Correlated anomalous phase diffusion of coupled phononic modes in a sideband-driven resonator
Authors: Sun F. , Dong X. , Zou J. , Dykman M. I. , Chan H. B. 
Published: August 2016

AbstractThe dynamical backaction from a periodically driven optical cavity can reduce the damping of a mechanical resonator, leading to parametric instability accompanied by self-sustained oscillations. Here we study experimentally and theoretically new aspects of the backaction and the discrete time-translation symmetry of a driven system using a micromechanical resonator with two nonlinearly coupled vibrational modes with strongly differing frequencies and decay rates. We find self-sustained oscillations in both the low- and high-frequency modes. Their frequencies and amplitudes are determined by the nonlinearity, which also leads to bistability and hysteresis. The phase fluctuations of the two modes show near-perfect anti-correlation, a consequence of the discrete time-translation symmetry. Concurrently, the phase of each mode undergoes anomalous diffusion. The phase variance follows a power law time dependence, with an exponent determined by the 1/f-type resonator frequency noise. Our findings enable compensating for the fluctuations using a feedback scheme to achieve stable frequency downconversion.
Unravelling the electrochemical double layer by direct probing of the solid/liquid interface
Authors: Favaro Marco , Jeong Beomgyun , Ross Philip N. , Yano Junko , Hussain Zahid , Liu Zhi , Crumlin Ethan J. 
Published: August 2016

AbstractThe electrochemical double layer plays a critical role in electrochemical processes. Whilst there have been many theoretical models predicting structural and electrical organization of the electrochemical double layer, the experimental verification of these models has been challenging due to the limitations of available experimental techniques. The induced potential drop in the electrolyte has never been directly observed and verified experimentally, to the best of our knowledge. In this study, we report the direct probing of the potential drop as well as the potential of zero charge by means of ambient pressure X-ray photoelectron spectroscopy performed under polarization conditions. By analyzing the spectra of the solvent (water) and a spectator neutral molecule with numerical simulations of the electric field, we discern the shape of the electrochemical double layer profile. In addition, we determine how the electrochemical double layer changes as a function of both the electrolyte concentration and applied potential.
Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
Authors: Dang Fabin , Sun Xiujie , Ma Xiang , Wu Rong , Zhang Deyi , Chen Yaqiong , Xu Qian , Wu Yuting , Liu Yi 
Published: August 2016

AbstractAlthough food availability is a potent synchronizer of the peripheral circadian clock in mammals, the underlying mechanisms are unclear. Here, we show that hepatic Bmal1, a core transcription activator of the molecular clock, is post-transcriptionally regulated by signals from insulin, an important hormone that is temporally controlled by feeding. Insulin promotes postprandial Akt-mediated Ser42-phosphorylation of Bmal1 to induce its dissociation from DNA, interaction with 14-3-3 protein and subsequently nuclear exclusion, which results in the suppression of Bmal1 transcriptional activity. Inverted feeding cycles not only shift the phase of daily insulin oscillation, but also elevate the amplitude due to food overconsumption. This enhanced and reversed insulin signalling initiates the reset of clock gene rhythms by altering Bmal1 nuclear accumulation in mouse liver. These results reveal the molecular mechanism of insulin signalling in regulating peripheral circadian rhythms.
Association of Adiponectin Polymorphism with Metabolic Syndrome Risk and Adiponectin Level with Stroke Risk: A Meta-Analysis
Authors: Yuan Hui-Ping , Sun Liang , Li Xing-Hui , Che Fu-Gang , Zhu Xiao-Quan , Yang Fan , Han Jing , Jia Chun-Yuan , Yang Ze 
Published: August 2016

AbstractMany previous studies have provided evidence that the ADIPOQ +45T>G polymorphism (rs2241766) might cause metabolic syndrome (MS). As a cardiovascular manifestation of MS, the incidence of stroke is associated with adiponectin; however, the results remain controversial and inconsistent. Systematic searches of relevant studies published up to Dec 2014 and Jan 2016 on the ADIPOQ +45T>G polymorphism and the risk of MS and adiponectin levels and the risk of stroke, respectively, were conducted in MEDLINE and EMBASE. The odds ratio (OR) or risk ratio (RR) and their 95% confidence interval (95% CI) were extracted. Sixteen studies containing 4,113 MS cases and 3,637 healthy controls indicated a weak positive association between ADIPOQ +45 T>G and MS in the dominant genetic model (OR = 1.30, 95% CI = 1.03–1.65), which was also validated by stratified subgroup analyses. Twelve studies including 26,213 participants and 4,246 stroke cases indicated that 5 μg/ml increments in adiponectin level were not relevant to stroke risk (RR = 1.05, 95% CI = 1.00–1.10, P = 0.069). This study suggested a weak positive association of ADIPOQ +45T>G with MS and a strong association with metabolic-related disease. Additionally, adiponectin level was not a causal factor of increasing stroke risk.