bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastrointestinal symptoms in children with mastocytosis
Authors: Kasikhina E. I. , Nada A. Ya. , Zhukova O. V. , Ostretsova M. N. 
Published: October 2024

Introduction. Mastocytosis is a heterogeneous group of diseases characterized by the abnormal accumulation of clonal mast cells (MCs) in various tissues and organs, including skin, bone marrow, liver, spleen and lymph nodes. The clinical picture of cutaneous and indolent systemic mastocytosis is formed by a wide range of symptoms associated with activation of mast cells. Single European studies have demonstrated wide variability in the frequency of gastrointestinal symptoms (GI-symptoms)) in children with mastocytosis (from 15 to 50%).Aim. To analyze the frequency of mediator-related GI-symptoms in children with different subtypes and clinical forms of mastocytosis.Materials and methods. A prospective observational study included data from 289 children aged 3 to 17 years who were under observation at the Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology. Symptoms were assessed using the Pediatric grade scale of symptoms of mastocytosis. Clinical manifestations of reactions caused by mast cell degranulation were compared with data from clinical and laboratory studies. The concentrations of tryptase and histamine in the blood serum of patients were determined. The incidence of organomegaly and mesenteric lymphadenitis in children with mediating symptoms and without symptoms was determined using ultrasound.Results. 67 (23.2%) patients had GI symptoms. More than half of the patients (51.6%) indicated abdominal pain, 32.3% reported diarrhea. The severity of pain symptoms correlated with the level of serum tryptase (ρ = 0.564, p < 0.01). The incidence of hepatomegaly and mesadenitis in children with GI- symptoms was 19.4% and 25.4%, respectively. In a comparative analysis in groups of children with and without GI symptoms, the differences in the number of identified cases of organomegaly and mesadenitis were statistically significant (p < 0.001). An increase in histamine levels in the blood was detected in half of the patients with complaints of heartburn and nausea.Conclusion. Our results demonstrated that a study of the level of serum tryptase, ultrasound of the abdominal organs and lymph nodes should be carried out in all children with mediator-related GI-symptoms regardless of the clinical form of mastocytosis.
Seismic isolation design of high-rise shear wall structures in high-intensity areas
Authors: Li Shufeng , Du Shuting , Zhang Zhihui , Zhu Weijie 
Published: October 2024

Taking a shear wall structure in a high-intensity area of 20 floors as an example, the seismic reduction scheme of the structure was determined, and the Etabs software was used to conduct time history analysis on the seismic and non-seismic structures. The floor shear force, overturning moment, and short-term surface pressure of the isolation support were obtained. The results showed that under frequent earthquake action, the average maximum floor shear force in the X direction of the isolated upper structure was only about 28 % of that of the non-isolated structure. The maximum inter story shear ratio was 0.34, and the maximum floor shear force in the Y direction was only about 25 % of that of the non-isolated structure. The maximum inter story shear ratio was 0.31. The average maximum overturning moment of the upper structure in the X direction after isolation is about 30 % of that of the non-isolated structure. The maximum overturning moment ratio is 0.36, and the average overturning moment of the maximum floor in the Y direction is about 22 % of that of the non-isolated structure. The maximum overturning moment ratio is 0.26. Under rare earthquake action, the maximum inter story displacement angles in the X and Y directions of each floor of the seismic isolation structure are 1/302 and 1/446, respectively. The maximum surface pressure value of the isolation bearing under rare earthquake is 28.9 MPa, the minimum surface pressure value is 5.58 MPa, and the maximum displacement is 579 mm, which meets the requirements of the specifications. Overall, the seismic performance of the seismic isolation structure is good, and the isolation scheme is feasible.
Groundwater potential zone mapping of Llandrindod Wells, Wales, UK using GIS, remote sensing, and analytic hierarchy process
Authors: Kareem Hayder H. 
Published: October 2024

ABSTRACT
Groundwater is crucial for urban and rural water systems, especially as demand increases from climate change and population growth. This study addresses a gap in previous research on Groundwater Potential Zones (GWPZ). Drainage density, rainfall, slope, land use/land cover (LULC), soil, and geology, along with elevation were analyzed using ArcGIS and Remote Sensing with a weighted overlay method. GWPZs for Liandrindod Wells Watershed, Wales, UK is mapped using Multi-Criteria Analysis and Analytical Hierarchical Processing. Rainfall amounts range from very low (70–92 mm to very high (127–141 mm). The slope ranges from 0 to 195 degrees, with low slopes indicating high groundwater potential and high slopes indicating low potential. The LULC forming the region were water land, built-up area, cropland, rangeland, and treeland. The sub-basin soil falls into four distinct types: loam, sandy loam, sandy clay loam, and clay loam. The majority of the sub-basin is covered by rocks from the Silurian and Devonian periods. The following five zones make up the GWPZ map: Very High (147.7 km2) (2.9%), High (1943.4 km2) (38.3%), Moderate (2318.7 km2) (45.7%), Low (662.2 km2) (13%), and Very Low (4 km2) (0.08%). Groundwater-rich regions comprise about 87% of the study area.
Integrative Analysis Reveals Differential Characteristics of DDR1 Mutant and Wild-type Gastric Cancers and Constructs their Prediction Models
Authors: Tian Yonggang , Xie Yunqian , Yi Guirong , Yu FuBing , Bai Feihu , Wang Jun , Zhang Dekui 
Published: October 2024

Introduction:
The molecular typing of gastric cancer by TCGA is significant
for the precision treatment of gastric cancer. However, the molecular typing of gastric
cancer by TCGA lacks the typing of the rare gene DDR1. Therefore, this study aimed to
integrate the analysis to reveal the differential features of DDR1 mutant and wild-type
gastric cancers and construct their prediction models.

Methods:
RNAseq data from 375 gastric cancer patients were downloaded from the TCGA
database to comprehensively compare the differences between mutant DDR1 and
wild-type DDR1 gastric cancers and construct a prognostic model for wild-type DDR1
gastric cancer.

Results:
First, the mutation rate of DDR1 in gastric cancer was 3.23%. Second, the upregulated
genes of mutant DDR1 gastric cancer were different from those of wild-type
DDR1 gastric cancer in terms of KEGG and GO enrichment. Next, both mutant DDR1
gastric cancers and wild-type DDR1 gastric cancers were associated with EPIC scores
and tumour stemness in macrophages. In addition, mutant DDR1 gastric cancers were associated
with the iron death-related genes RPL8, CS, and FANCD2 and the m6A-related
gene RBM15, compared with wild-type DDR1 gastric cancers. Finally, the established
LASSO regression model confirmed that the survival rate of the high-risk group of wild--
type DDR1 gastric cancer would be lower than that of the low-risk group.

Conclusion:
This study may provide a new molecular typing method for gastric cancer
by comparing the differences between mutant DDR1 and wild-type DDR1 gastric cancer.
Prevalence and Associated Factors of Central Sensitization in Patients with Chronic Inflammatory Rheumatic Disease
Authors: Berrichi Imane , Taik Fatima Zahrae , Haddani Fouzia , Soba Nabil , Fourtassi Maryam , Abourazzak Fatima Ezzahra 
Published: October 2024

Objective:
Despite advances in the treatment of Chronic Inflammatory Rheumatic Disease
(CIRD), pain remains a significant burden for patients and doctors. This study explored the
prevalence and associated factors of central sensitization (CS) in patients with CIRD.

Methods:
This is a cross-sectional study that included patients with CIRD followed at the University
Hospital Center in Tangier. Sociodemographic and clinical data were collected. Nociceptive
pain was assessed by the Visual Analogue Scale (VAS), disease activity by DAS-28 and ASDAS,
and CS by the validated Moroccan version of the Central Sensitization Inventory part A (CSI-A).
The Pain Catastrophizing Scale (PCS) was used to assess pain-related catastrophic thoughts, and
the PHQ-9 (Pain Health Questionnaire) was used to determine the severity of depressive symptoms.

Results:
We included 189 patients; 107 (56.61%) had rheumatoid arthritis. The median duration
of evolution of CIRD was 8 years, and the mean age was 47.49 ± 13.70 years, and 75.7% were women.
The mean pain VAS was 4.77+-2.76, and 37.6% of patients were in remission. The mean
central sensitization score was 37.42+- 16.75, with 44.9% having a CSI score≥40. In univariate
and multivariate analysis, our study showed that central sensitization is associated with pain severity
(β = 1.945(0.050-1.916), p = 0.039) and depression (β = 1.790(1.221-2.154), p ≤0.001)(8). A
statistically significant correlation was found between the CSI-A score and pain VAS (r = 0.32, p
<0.001).

Conclusion:
Our study showed that almost half of our patients with CIRD had CS. The main factors
associated with CS in our patients were pain severity and depression. We also found a significant
correlation between pain VAS and CSI.
Berberine Ameliorates High-fat-induced Insulin Resistance in HepG2 Cells by Modulating PPARs Signaling Pathway
Authors: Zhang Lingxiao , Yang Chenghao , Ding Xinyue , Zhang Hui , Luan Yuling , Tang Yueer , Liu Zongjun 
Published: October 2024

Background:
Berberine (BBR), also known as berberine hydrochloride, was isolated
from the rhizomes of the Coptis chinensis. Studies have reported that BBR plays an important role
in glycolipid metabolism, including insulin (IR). The targets, and molecular mechanisms of BBR
against hyperlipid-induced IR is worthy to be further studied.

Material and Methods:
The related targets of BBR were identified via Pharmmapper database
and relevant targets of diabetes were obtained through GeneCards and Online Mendelian Inheritance
in Man (OMIM) database. The common targets were employed with the STRING database
and visualized with the protein-protein interactions (PPI) network. Gene Ontology (GO) and Kyoto
Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed to explore
the biological progress and pathways. In vitro, human hepatocellular carcinomas (HepG2) cell
was used as experimental cell line, and an insulin resistant HepG2 cell model (IR-HepG2) was
constructed using free fatty acid induction. After intervention with BBR, glucose consumption
and uptake in HepG2 cells were observed. Molecular docking was used to test the interaction between
BBR and key targets, and real-time fluorescence quantitative PCR was used to detect the
regulatory effect of BBR on related targets.

Results:
262 overlapped targets were extracted from BBR and diabetes. In the KEGG enrichment
analysis, the peroxisome proliferator activated receptor (PPAR) signaling pathway was included.
In vitro experiments, BBR can significantly increase sugar consumption and uptake in IR HepG2
cells, while PPAR inhibitors can weaken the effect of BBR on IR-HepG2.

Conclusion:
The PPAR signaling pathway is one of the important pathways for BBR to improve
high-fat-induced insulin resistance in HepG2 cells.

conclusion:
The PPAR signaling pathway is one of the important pathways for BBR to improve high-fat induced insulin resistance in HepG2 cells.
Reducing Stoichiometric Excess of Base to Catalytic Amount: Revisiting Staudinger Reaction for -lactam Synthesis
Authors: Yadav Sonu , Ray Devalina , Banik Bimal Krishna 
Published: October 2024

Background:
-lactams have been primarily utilized as a leading class of effective antibiotics.
They have been found to show activity against various diseases, prompting the scientific
community to prioritise innovative protocols for their synthesis. The general and well-known synthetic
strategy involves the classical Staudinger reaction exhibiting [2+2] cycloaddition reaction.
However, the protocol utilizes stoichiometric excess of base for efficient product formation.

Objective:
A smarter and more acceptable approach for the synthesis of -lactams would be to
reduce the excess base to a catalytic amount, furnishing a catalytic version of the Staudinger reaction.
The modified version can eliminate the hazards arising out of excess use of the base, ultimately
promoting the environmentally benign approach.

Methods:
With this hypothesis, a base-catalyzed approach in dimethyl formamide (DMF) towards
the synthesis of -lactam via Staudinger reaction has been endorsed under moderate reaction conditions.

Results:
The scope of the substrates was explored with both electron-withdrawing and electronreleasing
substitutions in the formation of -lactam. The reduction of the base amount from stoichiometric
to catalytic amount was justified by the involvement of DMF in generating the basic
condition for the reaction.

Conclusion:
It was hypothesized that the decomposition of DMF under the base-catalysed reaction
condition can generate dimethylamine, which produces the required basic environment.

conclusion:
A base-catalysed approach in dimethyl formamide (DMF) towards the synthesis of β-lactam via Staudinger reaction has been endorsed under moderate reaction conditions. The substrates scope was explored with both electron withdrawing and electron releasing substitutions in the formation of β-lactam. The reduction of base amount from stoichiometric to catalytic was justified by the involvement of DMF in generating the basic condition for the reaction. It was hypothesized that the decomposition of DMF under the base catalysed reaction condition can generate dimethylamine which produces the required basic environment.
Review of Lipid Nanoparticles for Breast Cancer Management: Targeting Strategies and Clinical Perspective
Authors: Almurisi Samah Hamed , En Goo Wei , Hafiq Muhamad Zakwan , Sheng Leong Khai , Sri Prasanthi , Mazlan Nadiatul Azra Binti Ahmad , Bhatnagar Payal , Madheswaran Thiagarajan 
Published: October 2024

Abstract:
Chemotherapy, a conventional breast cancer treatment, has limitations due to its nonspecific
mechanisms and undesirable side effects. Lipid-based nanoparticles (LNPs) have
emerged as a versatile and superior platform for targeted breast cancer treatment, offering several
distinct advantages over traditional therapies. This class of nanocarriers, which includes solid lipid
nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and liposomes, enhances the bioavailability
and stability of therapeutic agents while minimizing systemic toxicity. LNPs can be engineered
to precisely target breast cancer cells by exploiting tumor-specific markers, enabling selective
delivery of chemotherapeutic agents and reducing off-target effects. SLNs provide controlled
drug release and improved drug retention within the tumor, while NLCs offer higher drug-loading
capacities and better stability. Liposomes, with their flexible design, allow for the encapsulation
of both hydrophilic and hydrophobic drugs and can be modified for active targeting through surface
functionalization. These lipid-based carriers also address the challenges of multi-drug resistance
(MDR) by enhancing intracellular drug concentration and overcoming efflux mechanisms.
In this review, we focus on lipid-based nanoparticles- a subtype of nanoparticles, and their potential
advantages as drug delivery systems for breast cancer treatment. Results revealed that lipidbased
nanoparticles have shown potential in breast cancer management, these include improved
drug efficacy, enhanced ability to overcome cancer therapy resistance, and effective drug carrier
for co-loaded drugs.
Choro N. 1, de Quincas Laranjeiras: manuscrito e critérios para uma nova edição
Authors: Amorim Humberto 
Published: October 2024

Ancorado nos pressupostos teóricos de Figueiredo (2016) e coadunado com os esforços de resgatar o repertório pioneiro da guitarra no Brasil (Ávila et al., 2020; Habib, 2013, Lima 2023; Prando, 2022, 2023; Taborda, 2021), o artigo apresenta um manuscrito até então inédito do Choros N. 1, atribuído a um dos personagens antigos mais decisivos da guitarra carioca, Joaquim Francisco dos Santos, o Quincas Laranjeiras (1873–1935). O objetivo, de forma específica, é oferecer subsídios para uma edição moderna que colabore para a difusão da obra e, de forma geral, jogar luz tanto sobre a produção de Quincas recentemente redescoberta quanto sobre o significativo repertório do período que ainda precisa ser explorado.
Testing 3 Modalities (Voice Assistant, Chatbot, and Mobile App) to Assist Older African American and Black Adults in Seeking Information on Alzheimer Disease and Related Dementias: Wizard of Oz Usability Study
Authors: Bosco Cristina , Shojaei Fereshtehossadat , Theisz Alec Andrew , Osorio Torres John , Cureton Bianca , Himes Anna K , Jessup Nenette M , Barnes Priscilla A , Lu Yvonne , Hendrie Hugh C , Hill Carl V , Shih Patrick C 
Published: October 2024

Background
Older African American and Black adults are twice as likely to develop Alzheimer disease and related dementias (ADRD) and have the lowest level of ADRD health literacy compared to any other ethnic group in the United States. Low health literacy concerning ADRD negatively impacts African American and Black people in accessing adequate health care.

Objective
This study explored how 3 technological modalities—voice assistants, chatbots, and mobile apps—can assist older African American and Black adults in accessing ADRD information to improve ADRD health literacy. By testing each modality independently, the focus could be kept on understanding the unique needs and challenges of this population concerning the use of each modality when accessing ADRD-related information.

Methods
Using the Wizard of Oz usability testing method, we assessed the 3 modalities with a sample of 15 older African American and Black adults aged >55 years. The 15 participants were asked to interact with the 3 modalities to search for information on local events happening in their geographical area and search for ADRD-related health information.

Results
Our findings revealed that, across the 3 modalities, the content should avoid convoluted and complex language and give the possibility to save, store, and share it to be fully accessible by this population. In addition, content should come from credible sources, including information tailored to the participants’ cultural values, as it has to be culturally relevant for African American and Black communities. Finally, the interaction with the tool must be time efficient, and it should be adapted to the user’s needs to foster a sense of control and representation.

Conclusions
We conclude that, when designing ADRD-related interventions for African American and Black older adults, it proves to be crucial to tailor the content provided by the technology to the community’s values and construct an interaction with the technology that is built on African American and Black communities’ needs and demands.
Kewenangan hakim dalam menghitung kerugian keuangan negara dalam perkara tindak pidana korupsi (Analisa Putusan Nomor : 3/Pid.Sus-Tpk/2022/PN Dps)
Authors: Dewi Damaiyanti  
Published: October 2024

Tindakan korupsi adalah merupakan tindak pidana yang dimana perbuatan korupsi ini sangat merugikan dikarenakan ada suatu hak â€“ hak yang mestinya orang lain dapatkan tetapi dipergunakan untuk kepentingan individu. Dalam penindakan kasus korupsi di indonesia sudah terdapat peradilan khusus yakni pengadilan tindak pidana korupsi (TIPIKOR). Hakim mempunyai kewenangan dalam menghitung kerugian pada tindak korupsi. Dari pembahasan ini maka terdapat beberapa permasalahan yakni Bagaimanakah pengaturan kewenangan hakim dalam menghitung kerugian Negara dalam tindak pidana korupsi? Dan Bagaimanakah kewenangan hakim dalam menghitung kerugian Negara pada tindak pidana korupsi berdasarkan Surat Edaran Mahkamah Agung Nomor 4 Tahun 2016 dalam putusan perkara tentang tindak pidana korupsi? (Analisa putusan Nomor 3/Pid.Sus-Tpk/2022/PN Dps). Metode yang digunakan ialah hukum normatif. Kewenangan hakim dalam menghitung kerugian keuangan Negara pada tindak pidana korupsi berdasarkan Surat Edaran Mahkamah Agung Nomor 4 Tahun 2016.
Sanksi Pidana Terhadap Pelaku Tindak Pidana Penganiayaan Hewan
Authors: Firdaus Adji Prasetyo  , I Made Sepud  , I Made Minggu Widyantara  
Published: October 2024

Hewan itu makhluk yang memiliki rasa untuk merasakan apa yang dinamakan rasa sakit tidak hanya dijadikan hewan peliharan dan hewan pekerja atau ternak yang hanya diakui kepemilikannya tetapi juga harus dijaga sehingga tidak dari penganiayaan itu dilarang. Diangkat yaitu dua rumusan dari masalah, Bagaimanakah pengaturan tindak pidana penganiayaan hewan di Indonesia? Serta Bagaimanakah sanksi pidana terhadap pelaku penganiayaan hewan sehingga menyebabkan kematian? Manfaat dari metode normatif sekira mampu membantu menjawab masalah ini. Hasil teliti diketahui pada UU No.18/2009 diubah UU No.41/2014 serta dalam hukum KUHP yang dicantumkan dalam pasal Pasal 302 serta Pasal 540 mengatur terkait penganiayaan terhadap hewan dengan sanksi yang dapat diterima jika melakukan penganiayaan terhadap hewan dapat berupa sanksi penjara, kurungan maupun denda. Adanya aturan terkait larangan penyiksaan hewan tapi pada nyatanya masih banyak penyiksaan terhadap hewan sehingga dibutuhkan penegakan hukum yang ketat yang mampu mengurangi tingkat penyiksaan terhadap hewan.
Effects of fishmeal replacement with spirulina (Arthrospira platensis) and Sargassum ilicifolium meal on growth and health indices of Asian seabass (Lates calcarifer) juveniles
Authors: Mohammadian Takavar , Mozanzadeh Mansour Torfi , Mousavi Parva , Mesbah Mehrzad , Khosravi Mohammad 
Published: October 2024

Abstract
The influence of dietary fishmeal (FM) replacement with a mixture (1:1) of spirulina (Arthrospira platensis) and a brown seaweed (Sargassum ilicifolium) in Asian seabass (Lates calcarifer, 45.0 ± 0.2) performance was evaluated. Dietary FM was replaced with the algal mixture at 5 (MIX5%) and 10% (MIX10%) and a diet without algal mixture served as control group. One hundred and thirty five L. calcarifer juveniles were stocked into nine 300-L circular containers (15 fish/tank) filled with seawater (salinity = 46.0 ± 0.2 g L-1; temperature = 31.5 ± 2.5 °C) with 80% daily water exchange rate. Each dietary treatment was conducted in triplicate. The experimental feeds were offered to fish thrice daily up to satiation for 60 days. Fish in MIX5% group had the highest weight gain (Ca. 12%) that was associated with higher feed intake compare to the control. Viscerosomatic index reduced in fish fed MIX10% diet compared to control group (8.6 vs. 7.6%). Amylase, alkaline phosphatase, total protease and trypsin activities significantly increased in fish fed MIX5% group (P < 0.05). Liver superoxide dismutase activity (36.1 U/ mg protein) and glutathione (33.3 µmol / g tissue) level increased in fish fed MIX5% diet. MIX5% group had higher white blood cell counts than other groups. Plasma cholesterol decreased (Ca. 20 mg / dL) but plasma calcium content increased in fish fed algal mix-supplemented diets (P < 0.05). Plasma triglycerides, total protein, globulin, and alkaline phosphatase decreased in fish fed MIX10% diet. Based on the above-mentioned findings, dietary FM replacement with micro and macroalgae mixture at 5% is recommended for growth and improving health status in L. calcarifer juveniles.