bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spot Weather Forecasts: Improving Utilization, Communication, and Perceptions of Accuracy in Sophisticated User Groups
Authors: Wall Tamara U. , Brown Timothy J. , Nauslar Nicholas J. 
Published: February 2017

Abstract
Spot weather forecasts (SWFs) are issued by Weather Service offices throughout the United States and are primarily for use by wildfire and prescribed fire practitioners for monitoring local-scale weather conditions. This paper focuses on use of SWFs by prescribed fire practitioners. Based on qualitative, in-depth interviews with fire practitioners and National Weather Service forecasters, this paper examines factors that influence perceptions of accuracy and utilization of SWFs. Results indicate that, while several well-understood climatological, topographical, and data-driven factors influence forecast accuracy, social factors likely have the greater impact on perceptions of accuracy, quantitative accuracy, and utilization. These include challenges with building and maintaining relationships between forecasters and fire managers, communication issues around updating SWFs, and communicating forecast confidence and uncertainty. Operationally, improved quantitative skill in a forecast is always desirable, but key opportunities for improving accuracy and utilization of these forecasts lie in 1) enhancing the processes and mechanisms for communication between a Weather Forecast Office and fire practitioners—before, during, and after an SWFs is issued—and 2) working with the wildland fire community to experiment with forecast uncertainty and confidence information in SWFs and evaluate impacts of these approaches.
Association between plasma proprotein convertase subtisilin/kexin type 9 concentration and coronary artery calcification
Authors: Zhao Xi , Zhang Hui-Wen , Li Sha , Zhang Yan , Xu Rui-Xia , Zhu Cheng-Gang , Wu Na-Qiong , Guo Yuan-Lin , Qing Ping , Li Xiao-Lin , Liu Geng , Dong Qian , Sun Jing , Li Jian-Jun 
Published: February 2017

Background Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) has been reported to be related to several risk factors and diseases such as inflammatory markers and coronary artery disease. The aim of present study was to investigate whether plasma PCSK9 concentration was associated with coronary artery calcification. Methods A total of 403 consecutive untreated patients with angina-like chest pain, who received electron beam computed tomography, were enrolled and a coronary artery calcification score (CACS) was also measured. The baseline clinical characteristics were collected and blood sample was taken after 12-h fasting. The plasma PCSK9 concentrations were determined by ELISA in all patients, and the relationship between plasma PCSK9 concentrations and CACS was investigated. Results Patients with coronary artery calcification (CACS > 0) had significant higher plasma PCSK9 concentrations compared with those (CACS = 0) without coronary artery calcification (258.58 ± 69.53 ng/mL vs. 202.53 ± 52.17 ng/mL, P < 0.001). Patients with highest PCSK9 concentrations had the highest CACS. Multivariable linear regression analysis suggested that PCSK9 was independently associated with coronary artery calcification ( P = 0.002) after adjusting for traditional cardiovascular risk factors. Furthermore, the area under the curve for the plasma PCSK9 concentration in predicting coronary artery calcification was 0.736 (95% CI: 0.687–0.785, P < 0.001), with a sensitivity of 66% and specificity of 70%. Conclusion A positive association between plasma PCSK9 concentration and coronary artery calcification in untreated patients with angina-like chest pain was observed in our study, suggesting that further investigation may be needed in order to confirm our primary findings and explore the clinical implications.
Revitalizing genetically-modified mouse strains using frozen–thawed sperm after up to 192 h of refrigerated epididymis transportation
Authors: Moreno-del Val Gonzalo , Muñoz-Robledano Patricia 
Published: February 2017

In the scientific interchange of genetically-modified mouse strains the transportation of refrigerated epididymis has several advantages over the transportation of live animals, especially with regard to the 3R (replacement, reduction and refinement) principles. The major limiting factor is the duration of the transportation. Previous reports have shown that sperm collected from transported epididymis maintained their fertility for around 72 h, but there are no published data with longer transportation times, and this window of time may be too short, especially for international shipments and where locations are not well connected. In this study live pups were born using frozen–thawed sperm after up to 192 h (8 days) of transportation, using a special in vitro fertilization design which resulted in a fertilization rate of 10.5%.
Novel developments in foam sclerotherapy: Focus on Varithena® (polidocanol endovenous microfoam) in the management of varicose veins
Authors: Star Phoebe , Connor David E , Parsi Kurosh 
Published: February 2017

Scope Varithena® is a recently approved commercially available drug/delivery unit that produces foam using 1% polidocanol for the management of varicose veins. The purpose of this review is to examine the benefits of foam sclerotherapy, features of the ideal foam sclerosant and the strengths and limitations of Varithena® in the context of current foam sclerotherapy practices. Method Electronic databases including PubMed, Medline (Ovid) SP as well as trial registries and product information sheets were searched using the keywords, ‘Varithena’, ‘Varisolve’, ‘polidocanol endovenous microfoam’, ‘polidocanol’ and/or ‘foam sclerotherapy/sclerosant’. Articles published prior to 20 September 2016 were identified. Results Foam sclerosants have effectively replaced liquid agents due to their physiochemical properties resulting in better clinical outcomes. Medical practitioners commonly prepare sclerosant foam at the bedside by agitating liquid sclerosant with a gas such as room air, using techniques as described by Tessari or the double syringe method. Such physician-compounded foams are highly operator dependent producing inconsistent foams of different gas/liquid compositions, bubble size, foam behaviour and varied safety profiles. Varithena® overcomes the variability and inconsistencies of physician-compounded foam. However, Varithena® has limited applications due to its fixed sclerosant type and concentration, cost and lack of worldwide availability. Clinical trials of Varithena® have demonstrated efficacy and safety outcomes equivalent or better than physician-compounded foam but only in comparison to placebo alone. Conclusion Varithena® is a promising step towards the creation of an ideal sclerosant foam. Further assessment in independent randomised controlled clinical trials is required to establish the advantages of Varithena® over and above the current best practice physician-compounded foam.
Long-Acting Injectable Antipsychotics: Evidence of Effectiveness and Use
Authors: Manchanda Rahul , Chue Pierre , Malla Ashok , Tibbo Phil , Roy Marc-André , Williams Richard , Iyer Srividya , Lutgens Danyael , Banks Nicola 
Published: February 2017

Objective To review the evidence for the role of long-acting injectable (LAI) antipsychotics (APs), especially the second-generation AP (SGA) LAIs, in the treatment of schizophrenia and to discuss the use rates of LAIs in Canada. Method A search of online medical databases was conducted of the published literature (1995–2012) of the effects of LAIs on the domains of remission, adherence, relapse, and hospitalization. Results obtained from randomized controlled trials (RCTs), systematic reviews, meta-analyses, and large-scale observational studies were included. Expert consensus data were also solicited on LAI use within a Canadian context. Results While the efficacy of LAIs, compared with placebo, is well established, the evidence from RCTs is equivocal for any specific advantage for SGA LAIs, compared with oral medications, probably owing to challenges in conducting such RCTs. Evidence from methodologically less rigorous studies and from clinical practice suggests some advantages in achieving and maintaining remission, risk of relapse, and hospitalization. The rate of LAI (first-generation AP and SGA) use from published outpatient studies is low at 6.3% in Canada, compared with 15% to 80% worldwide. However, there is a relatively high rate of use in specific early psychosis programs and in conjunction with community treatment orders in Canada. Conclusions LAIs are at least as effective as oral APs in the treatment of psychotic disorders. The former may have specific advantages for patients who demonstrate covert nonadherence. The underuse of LAIs in Canada needs to be better understood and addressed.
Long-Acting Injectable Antipsychotics: Recommendations for Clinicians
Authors: Malla Ashok , Tibbo Phil , Chue Pierre , Levy Emmanuelle , Manchanda Rahul , Teehan Michael , Williams Richard , Iyer Srividya , Roy Marc-André 
Published: February 2017

A major source of limitation to the real effectiveness of antipsychotics is the high rate of patient nonadherence or, more frequently, partial adherence. using long-acting injectable (LAI) formulations is likely to reduce the impact of such adherence problems. Conversely, the use of LAIs in Canada remains low relative to many other jurisdictions. Based on effectiveness data from randomized control trials and other, less rigorous, studies, as well as our 2 qualitative studies exploring numerous issues around the use of LAIs, including their low use, we put forward 10 different recommendations for consideration by clinicians. These are also based on the experience of many clinicians and clinician scientists. These recommendations address mostly clinical challenges associated with the use of LAIs. Their application in clinical settings is illustrated in our report through several case examples highlighting the large variation across patients and different phases of illness. It is recommended that LAIs should be considered as a treatment option for psychotic disorders across all phases, including the first 2 to 5 critical years.
Hospital acquisitions, parenting styles and management accounting change: An institutional perspective
Authors: Dossi Andrea , Lecci Francesca , Longo Francesco , Morelli Marco 
Published: February 2017

Many healthcare scholars have applied institutional theories to the study of management accounting systems (MAS) change. However, little attention has been devoted to MAS change within groups. Kostova et al. highlight the limitations of traditional institutional frameworks in studying groups since they are characterised not only by the existence of external institutional environments but also by intra-organisational (meso-level) ones. Given this background, the research question is: how does the meso-level institutional environment affect MAS change in healthcare groups? We use a longitudinal multiple-case study design to understand the role of headquarters in shaping local MAS change. We would expect companies to adopt similar MAS. However, we argue that the relationship between external institutions and MAS change cannot be wholly understood without taking into consideration the role of headquarters. Our analysis shows how hospitals facing the same external institutional environment implement different MAS as a consequence of different parenting styles. From a scientific perspective, our article contributes to broaden traditional institutional theoretical frameworks.
Incidental Dose to Pelvic Nodes in Bladder-Only Radiotherapy: Is It Clinically Relevant?
Authors: Lewis Shirley , Murthy Vedang , Mahantshetty Umesh , Shrivastava Shyam Kishore 
Published: February 2017

Background and Purpose: Although there is a strong biological rationale to electively treat the pelvic nodes during bladder preservation, its clinical benefit is uncertain. This may be explained by the incidental dose received by the nodal regions when treating the bladder alone. This study was conducted to investigate the doses received by the different pelvic nodal regions when the bladder alone is treated by standard conformal radiotherapy. Methods and Materials: The computed tomography data sets of 20 patients with node-negative muscle-invasive bladder cancer treated in a bladder preservation protocol were studied. Patients were originally treated with conformal radiotherapy to the bladder alone. Replanning was done with additional delineation of the pelvic nodal regions namely common iliac (upper and lower), presacral, internal iliac, obturator, and external iliac. Dose volume parameters such as Dmean, Dmax, D100%, D66%, D33%, V40, and V50 to each of the nodal regions were estimated for all patients. Results: The obturator nodes received the highest dose among all nodal regions. The mean dose received by obturator, external iliac, and internal iliac regions was 59, 45, and 36 Gy, respectively. The dose received by these 3 regions in the full bladder state was 63, 52, and 47 Gy, respectively. The dose received by all other pelvic nodal regions was low and not clinically relevant. Conclusion: The incidental dose received by obturator and external iliac nodes is clinically significant in bladder-only radiation, possibly enough to influence micrometastatic disease. This may be a reason for the lack of clear benefit seen with nodal irradiation in bladder cancer. Advances in Knowledge: This study highlights that the incidental dose received by obturator and external iliac nodes is clinically significant in bladder-only radiation. The obturator nodes received the highest dose among all nodal regions with mean dose of 59 Gy.
Microcatheter shaping using intravascular placement during intracranial aneurysm coiling
Authors: Yamaguchi Shinya , Ito Osamu , Koyanagi Yuya , Iwaki Katsuma , Matsukado Koichiro 
Published: February 2017

Background The selection of a pre-shaped microcatheter or a shaping method must be carefully considered for successful aneurysm coiling. The objective of this report is to verify the use of intravascular placement to establish an appropriate microcatheter shape. Methods Fifteen patients (15 aneurysms) were included in this study because of the predicted difficulty of microcatheter insertion and stabilisation. The SL-10 straight microcatheter was inserted into the parent artery until the tip of the catheter passed through the neck of the aneurysm. After 5 minutes, the microcatheter was pulled out and the shape acquired from intravascular placement was confirmed and compared with the three-dimensional rotational angiography. In addition, the microcatheter tip was steam-shaped for coiling and coil embolisation was performed. A silicone flow model was also used to confirm our findings. The first experiment compared the bend angle in four different microcatheters placed in the model for 5 minutes. In the second experiment, the SL-10 straight microcatheter was placed in the model, and the bend angle was measured at 2.5, 5, 7.5 and 10 minutes to observe the changes in bend angle over time. Results The SL-10 straight microcatheter, in place for 5 minutes, acquired a shape similar to the patient’s own vessel. Among the 15 patients included, 13 were treated using an intravascular shaped microcatheter. In the flow model experiments, the SL-10 most easily acquired the vessel shape, and the shape change stabilised after 5 minutes. Conclusion Shaping the SL-10 straight microcatheter using intravascular placement is an effective shaping method for aneurysm coil embolisation.
Overuse Physeal Injuries in Youth Athletes
Authors: Arnold Amanda , Thigpen Charles A. , Beattie Paul F. , Kissenberth Michael J. , Shanley Ellen 
Published: February 2017

Context: Despite rising awareness of the risks associated with sports participation, overuse injuries continue to increase in youth athlete populations. Physeal injuries are one type of overuse injury exclusive to pediatric populations that are often sustained during athletic practice or competition. Overuse physeal injuries are, in theory, preventable; however, little consensus has been reached surrounding the risk factors, prevention, and treatment strategies. Objective: This systematic review summarizes the best available evidence concerning overuse physeal injuries in youth and adolescent athletes. It can be used to develop prevention and treatment programs specific to this population. Data Sources: PubMed and Academic Search Complete (EBSCOhost) were explored using the keyword physeal injuries from January 1950 through May 2015 to identify 24 studies. Study Selection: Original research studies of athletic populations with mechanisms of injury related to sport were chosen. Study Design: Systematic review. Level of Evidence: Level 3. Data Extraction: Data were extracted as available from 24 eligible studies. Study quality was rated using the Oxford Centre for Evidence-based Medicine (OCEBM) guidelines. Results: Risk factors for injury include periods of accelerated growth, chronological age, body size, training volume, and previous injury. Injury prevention strategies currently emphasize participation limitations and sport-specific training programs in skeletally immature athletes. The most effective treatment after an overuse physeal injury was an extended period of active rest and joint immobilization when necessary. Conclusion: Overuse physeal injuries are multifactorial in nature. Muscular imbalances after accelerated growth periods predispose young athletes to overuse injuries. Modifiable risk factors such as flexibility, strength, and training volume should be regularly monitored to prevent these injuries.
Medial Patellofemoral Ligament Reconstruction Femoral Tunnel Accuracy
Authors: Hiemstra Laurie A. , Kerslake Sarah , Lafave Mark 
Published: February 2017

Background: Medial patellofemoral ligament (MPFL) reconstruction is a procedure aimed to reestablish the checkrein to lateral patellar translation in patients with symptomatic patellofemoral instability. Correct femoral tunnel position is thought to be crucial to successful MPFL reconstruction, but the accuracy of this statement in terms of patient outcomes has not been tested. Purpose: To assess the accuracy of femoral tunnel placement in an MPFL reconstruction cohort and to determine the correlation between tunnel accuracy and a validated disease-specific, patient-reported quality-of-life outcome measure. Study Design: Case series; Level of evidence, 4. Methods: Between June 2008 and February 2014, a total of 206 subjects underwent an MPFL reconstruction. Lateral radiographs were measured to determine the accuracy of the femoral tunnel by measuring the distance from the center of the femoral tunnel to the Schöttle point. Banff Patella Instability Instrument (BPII) scores were collected a mean 24 months postoperatively. Results: A total of 155 (79.5%) subjects had adequate postoperative lateral radiographs and complete BPII scores. The mean duration of follow-up (±SD) was 24.4 ± 8.2 months (range, 12-74 months). Measurement from the center of the femoral tunnel to the Schöttle point resulted in 143 (92.3%) tunnels being categorized as “good” or “ideal.” There were 8 failures in the cohort, none of which occurred in malpositioned tunnels. The mean distance from the center of the MPFL tunnel to the center of the Schöttle point was 5.9 ± 4.2 mm (range, 0.5-25.9 mm). The mean postoperative BPII score was 65.2 ± 22.5 (range, 9.2-100). Pearson r correlation demonstrated no statistically significant relationship between accuracy of femoral tunnel position and BPII score ( r = –0.08; 95% CI, –0.24 to 0.08). Conclusion: There was no evidence of a correlation between the accuracy of MPFL reconstruction femoral tunnel in relation to the Schöttle point and disease-specific quality-of-life scores. Graft failure was not related to femoral tunnel placement. The patellofemoral instability population is complex, and patients present with multiple risk factors that, in addition to the accuracy of femoral tunnel position, contribute to quality of life and warrant further investigation.
Days out of role due to common physical and mental conditions in Portugal: Results from the WHO World Mental Health Survey
Authors: Cardoso Graça , Xavier Miguel , Vilagut Gemma , Petukhova Maria , Alonso Jordi , Kessler Ronald C. , Caldas-de-Almeida José Miguel 
Published: February 2017

BackgroundOne important aspect of the societal burden of mental disorders is the extent to which these problems cause disability.AimsTo assess days out of role associated with commonly occurring mental disorders in comparison with physical disorders in Portugal.MethodNational cross-sectional survey, with home interviews carried out with 3849 adult (aged 18+) respondents (57.3% response rate).ResultsTwelve-month prevalence for any mental disorder was 21.8%, any physical disorder 55.1% and any disorder 63.1%, with an average of 2.3 disorders per respondent with a disorder. Close to one out of every 10 respondents (9.2%) reported at least one day totally out of role in the past month (median of 6.4 days/any). The 18 conditions accounted for 78.2% of all days out of role, with 20.2% because of mental disorders and 59.2% because of physical disorders.ConclusionsMental disorders account for a substantial proportion of all role disability in the Portuguese population. Early detection and intervention would have a positive societal effect. Owing to highly frequent comorbidity, simultaneous management of mental and physical disorder comorbidities is advised for greater effect.
The Comeback of Objects: On vacuum cleaners, plastic bottles, hair dryers, chairs, brooms, sand & other nonhuman performers on contemporary stages
Authors: Ruhsam Martina 
Published: February 2017

Abstract
The article scrutinizes the recent phenomenon of an increased involvement of things into contemporary choreographies and thematizes the relation between human and nonhuman performers. It traces a shift from semantic investigations of objects in the 1990s to agential realist approaches since about 2008. By referring to Bruno Latour's conception of things as actants and by introducing basic notions of actor-networktheory, the essay proposes a posthumanist understanding of performativity (as outlined by Karen Barad) and ponders about the ethical, political and ecological implications of posthumanist choreographies/dance.
Deleuze’s “Puppetry” and the Ethics of Non-human Compositions
Authors: Wiame Aline 
Published: February 2017

Abstract
While the presence of marionettes and automata in contemporary performing arts can sometimes manifest the fear of a loss of life and humanity due to the mechanization of our societies, this article calls for a more constructivist approach to the question. With the help of Gilles Deleuze’s propositions about marionettes and Heiner Goebbels’ performance Stifters Dinge, this paper aims to show that puppets and automata are invitations to create and compose new possibilities of being, sensing, thinking and resisting in a world made of human and non-human elements that constantly mix.