bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Medical Risk Perception and Risk Taking Change with Age?
Authors: Hanoch Yaniv , Rolison Jonathan J. , Freund Alexandra M. 
Published: September 2016

AbstractAcross adulthood, people face increasingly more risky medical problems and decisions. However, little is known about changes in medical risk taking across adulthood. Therefore, the current cross‐sectional study investigated age‐related differences in medical risk taking with N = 317 adults aged 20–77 years using newly developed scenarios to assess medical risk taking, and additional measures designed to evaluate risk‐taking behavior in the medical domain. Greater expected benefits on the Domain‐Specific Risk‐Taking Scale—Medical (DOSPERT‐M) predicted more active risk taking, whereas higher perceived risk predicted less active risk taking. Next, we examined differences in active and passive risk taking, where passive risk taking refers to risk taking that is associated with inaction. Age was associated with less passive risk taking, but not with active risk taking, risk perception, or expected benefits on the DOSPERT‐M. Participants were overall more likely to opt for taking medical action than not, even more so for a scenario about a vaccine for a deadly flu than for a scenario about a chemotherapy treatment for cancer. Overall, participants were more likely to accept medication (vaccine or chemotherapy) for their child than for themselves. Increasing age was associated with a lower likelihood of accepting the treatment or vaccine for oneself. Taken together, our study provides important insights about changes in medical risk taking across adulthood when people face an increasing number of complex and risky medical decisions.
Systemic Risk in the Insurance Sector: A Review and Directions for Future Research
Authors: Eling Martin , Pankoke David Antonius 
Published: September 2016

AbstractThis article reviews the extant research on systemic risk in the insurance sector and outlines new areas of research in this field. We summarize and classify 48 theoretical and empirical research papers from both academia and practitioner organizations. The survey reveals that traditional insurance activity in the life, nonlife, and reinsurance sectors neither contributes to systemic risk nor increases insurers’ vulnerability to impairments of the financial system. However, nontraditional activities (e.g., credit default swap underwriting) might increase vulnerability, and life insurers might be more vulnerable than nonlife insurers due to higher leverage. Whether nontraditional activities also contribute to systemic risk is not entirely clear; however, the activities with the potential to contribute to systemic risk include underwriting financial derivatives and providing financial guarantees. This article is not only likely of interest to academics but also highly relevant for the industry, regulators, and policymakers.
Identification of Hysteresis Dynamics Using Duffing-Like and Bouc-Wen Models
Authors: Yeh Hung-Ping , Chien Yuan-Che , Tu Jia-Ying 
Published: September 2016

Two methods of identifying hysteresis behavior for dynamic systems is introduced and compared in this paper, which are Duffing-like and Bouc-Wen models. Many structural and mechanical systems including the unwanted hysteresis dynamics, such as rubber isolators, magnetoresistive sensors, and magnetorheological dampers, complicate the design, analysis, control, and application work. Hysteresis can be said a general property of dynamic systems, and many mathematical models have been proposed in the material, mechanical, and civil engineering literature, in order to identify the hysteresis dynamics. However, some of the models used in literature, including discontinuous and piecewise terms, are not able to duplicate the hysteresis dynamics accurately. In addition, the complicated and coupling effects of the parameters renders the identification work inefficient and inaccurate. As a result, these models still present difficulty in the process of mechanical design, parameter analysis, and control implementation.
The innovative Duffing-like model has been proposed, which is developed based on the original Duffing equation and is a second-order nonlinear ordinary differential equation. Parameters are decoupled in the model, such that the linear and nonlinear effects of the parameters on the hysteresis curve can be investigated. By adjusting the parameters individually, the stiffness, damping, and yielding dynamics are observed. By understanding the influence of each parameter, it is able to advance a standard process for identifying the hysteresis behavior for different dynamic systems. Therefore, in order to reflect the advantages of Duffing-like model, this paper compares the Duffing-like and Bouc-Wen models. Bouc-Wen model was proposed in literature since 1997, and a variety of modification, identification, and application work based on the Bouc-Wen model haven been discussed. However, the Bouc-Wen model is essentially a discontinuous equation and the parameters do not have explicit physical meaning. Therefore, the efficacy of control application using the Bouc-Wen model is very limited. In order to show can compare the Duffing-like and Bouc-Wen models, the parameter identification procedure and numerical simulation results are presented in the paper. In addition, the hysteresis system of a 400-N magnetorheological damper is used as an example for the identification and simulation study. The simulation results show that the Bouc-Wen model, which contains discontinuous functions and difficult-to-track parameters, is not able to provide a reliable basis for parameter tuning. In contract, the Duffing-like model allows the physical meaning of the parameters to be defined in a systematic manner.
Investigating deformable image registration and scatter correction for CBCT‐based dose calculation in adaptive IMPT
Authors: Kurz Christopher , Kamp Florian , Park Yang‐Kyun , Zöllner Christoph , Rit Simon , Hansen David , Podesta Mark , Sharp Gregory C. , Li Minglun , Reiner Michael , Hofmaier Jan , Neppl Sebastian , Thieke Christian , Nijhuis Reinoud , Ganswindt Ute , Belka Claus , Winey Brian A. , Parodi Katia , Landry Guillaume 
Published: September 2016

PurposeThis work aims at investigating intensity corrected cone‐beam x‐ray computed tomography (CBCT) images for accurate dose calculation in adaptive intensity modulated proton therapy (IMPT) for prostate and head and neck (H&N) cancer. A deformable image registration (DIR)‐based method and a scatter correction approach using the image data obtained from DIR as prior are characterized and compared on the basis of the same clinical patient cohort for the first time.MethodsPlanning CT (pCT) and daily CBCT data (reconstructed images and measured projections) of four H&N and four prostate cancer patients have been considered in this study. A previously validated Morphons algorithm was used for DIR of the planning CT to the current CBCT image, yielding a so‐called virtual CT (vCT). For the first time, this approach was translated from H&N to prostate cancer cases in the scope of proton therapy. The warped pCT images were also used as prior for scatter correction of the CBCT projections for both tumor sites. Single field uniform dose and IMPT (only for H&N cases) treatment plans have been generated with a research version of a commercial planning system. Dose calculations on vCT and scatter corrected CBCT (CBCTcor) were compared by means of the proton range and a gamma‐index analysis. For the H&N cases, an additional diagnostic replanning CT (rpCT) acquired within three days of the CBCT served as additional reference. For the prostate patients, a comprehensive contour comparison of CBCT and vCT, using a trained physician's delineation, was performed.ResultsA high agreement of vCT and CBCTcor was found in terms of the proton range and gamma‐index analysis. For all patients and indications between 95% and 100% of the proton dose profiles in beam's eye view showed a range agreement of better than 3 mm. The pass rate in a (2%,2 mm) gamma‐comparison was between 96% and 100%. For H&N patients, an equivalent agreement of vCT and CBCTcor to the reference rpCT was observed. However, for the prostate cases, an insufficient accuracy of the vCT contours retrieved from DIR was found, while the CBCTcor contours showed very high agreement to the contours delineated on the raw CBCT.ConclusionsFor H&N patients, no considerable differences of vCT and CBCTcor were found. For prostate cases, despite the high dosimetric agreement, the DIR yields incorrect contours, probably due to the more pronounced anatomical changes in the abdomen and the reduced soft‐tissue contrast in the CBCT. Using the vCT as prior, these inaccuracies can be overcome and images suitable for accurate delineation and dose calculation in CBCT‐based adaptive IMPT can be retrieved from scatter correction of the CBCT projections.
A Clonal Lineage of Fusarium oxysporum Circulates in the Tap Water of Different French Hospitals
Authors: Edel-Hermann Véronique , Sautour Marc , Gautheron Nadine , Laurent Julie , Aho Serge , Bonnin Alain , Sixt Nathalie , Hartemann Philippe , Dalle Frédéric , Steinberg Christian 
Published: September 2016

ABSTRACT

Fusarium oxysporum
is typically a soilborne fungus but can also be found in aquatic environments. In hospitals, water distribution systems may be reservoirs for the fungi responsible for nosocomial infections.
F. oxysporum
was previously detected in the water distribution systems of five French hospitals. Sixty-eight isolates from water representative of all hospital units that were previously sampled and characterized by translation elongation factor 1α sequence typing were subjected to microsatellite analysis and full-length ribosomal intergenic spacer (IGS) sequence typing. All but three isolates shared common microsatellite loci and a common two-locus sequence type (ST). This ST has an international geographical distribution in both the water networks of hospitals and among clinical isolates. The ST dominant in water was not detected among 300 isolates of
F. oxysporum
that originated from surrounding soils. Further characterization of 15 isolates by vegetative compatibility testing allowed us to conclude that a clonal lineage of
F. oxysporum
circulates in the tap water of the different hospitals.

IMPORTANCE
We demonstrated that a clonal lineage of
Fusarium oxysporum
inhabits the water distribution systems of several French hospitals. This clonal lineage, which appears to be particularly adapted to water networks, represents a potential risk for human infection and raises questions about its worldwide distribution.
Crz1p Regulates pH Homeostasis in Candida glabrata by Altering Membrane Lipid Composition
Authors: Yan Dongni , Lin Xiaobao , Qi Yanli , Liu Hui , Chen Xiulai , Liu Liming , Chen Jian 
Published: September 2016

ABSTRACT

The asexual facultative aerobic haploid yeast
Candida glabrata
is widely used in the industrial production of various organic acids. To elucidate the physiological function of the
C. glabrata
transcription factor Crz1p (CgCrz1p) and its role in tolerance to acid stress, we deleted or overexpressed the corresponding gene,
CgCRZ1
. Deletion of
CgCRZ1
resulted in a 60% decrease in the dry weight of cells (DCW) and a 50% drop in cell viability compared with those of the wild type at pH 2.0. Expression of lipid metabolism-associated genes was also significantly downregulated. Consequently, the proportion of C
18:1
fatty acids, the ratio of unsaturated to saturated fatty acids, and the ergosterol content decreased by 30%, 46%, and 30%, respectively. Additionally, membrane integrity, fluidity, and H
+
-ATPase activity were reduced by 45%, 9%, and 50%, respectively. In contrast, overexpression of CgCrz1p increased C
18:1
and ergosterol contents by 16% and 40%, respectively. Overexpression also enhanced membrane integrity, fluidity, and H
+
-ATPase activity by 31%, 6%, and 20%, respectively. Moreover, in the absence of pH buffering, the DCW and pyruvate titers increased by 48% and 60%, respectively, compared to that of the wild type. Together, these results suggest that CgCrz1p regulates tolerance to acidic conditions by altering membrane lipid composition in
C. glabrata
.

IMPORTANCE
This study provides insight into the metabolism of
Candida glabrata
under acidic conditions, such as those encountered during the industrial production of organic acids. We found that overexpression of the transcription factor CgCrz1p improved viability, biomass, and pyruvate yields at a low pH. Analysis of plasma membrane lipid composition indicated that CgCrz1p might play an important role in its integrity and fluidity and that it enhanced the pumping of protons in acidic environments. We propose that altering the structure of the cell membrane may provide a successful strategy for increasing
C. glabrata
productivity at a low pH.
Chloroplast Genome Sequence of Arabidopsis thaliana Accession Landsberg
erecta
, Assembled from Single-Molecule, Real-Time Sequencing Data
Authors: Stadermann Kai Bernd , Holtgräwe Daniela , Weisshaar Bernd 
Published: September 2016

ABSTRACT

A publicly available data set from Pacific Biosciences was used to create an assembly of the chloroplast genome sequence of the
Arabidopsis thaliana
genotype Landsberg
erecta
. The assembly is solely based on single-molecule, real-time sequencing data and hence provides high resolution of the two inverted repeat regions typically contained in chloroplast genomes.
Draft Genome Sequence of Marine Sponge Symbiont Pseudoalteromonas luteoviolacea IPB1, Isolated from Hilo, Hawaii
Authors: Sakai-Kawada Francis E. , Yakym Christopher J. , Helmkampf Martin , Hagiwara Kehau , Ip Courtney G. , Antonio Brandi J. , Armstrong Ellie , Ulloa Wesley J. , Awaya Jonathan D. 
Published: September 2016

ABSTRACT

We report here the 6.0-Mb draft genome assembly of
Pseudoalteromonas luteoviolacea
strain IPB1 that was isolated from the Hawaiian marine sponge
Iotrochota protea
. Genome mining complemented with bioassay studies will elucidate secondary metabolite biosynthetic pathways and will help explain the ecological interaction between host sponge and microorganism.
Sea-surface temperature evolution across Aptian Oceanic Anoxic Event 1a
Authors: Naafs B.D.A. , Pancost R.D. 
Published: September 2016

Abstract
Atmospheric CO2 possibly doubled during Oceanic Anoxic Event (OAE) 1a, likely in response to submarine volcanic outgassing. Despite being important for our understanding of the consequences of carbon cycle perturbations, the response of the climate system to this increase in greenhouse forcing is poorly constrained. Here we provide a new sea-surface temperature (SST) record from the mid-latitude proto–North Atlantic based on the organic geochemical TEX86 paleothermometer. Using different calibrations, including the newly developed Bayesian Spatially-varying Regression (BAYSPAR) deep-time analogue approach, we demonstrate that SSTs increased by ∼2–4 °C during OAE 1a and decreased by ∼4–6 °C at its end, both simultaneous with changes in δ13Corg, which we argue reflects changes in pCO2. We demonstrate that a clear latitudinal SST gradient prevailed during OAE 1a, contrary to the generally accepted view that a nearly flat SST gradient existed during OAE 1a and the Early Cretaceous. These results are more consistent with climate model simulations of the Cretaceous that have failed to produce flat SST gradients.
Factors Affecting Whether Or Not Cancer Patients Consider Using Acupuncture
Authors: Oh Byeongsang , Eade Thomas , Kneebone Andrew , Pavlakis Nick , Clarke Stephen , Eslick Guy , River Jo , Back Michael 
Published: September 2016

Objective To explore the factors associated with utilisation of an acupuncture service in a tertiary oncology setting in an Australian public hospital. Method Cancer patients attending oncology clinics at a university teaching hospital were invited to participate in the evaluation of acupuncture services from June 2014 to May 2015. Patients had a prior diagnosis of cancer (albeit at different stages) and were planning to receive, or were already receiving, systemic and/or radiation cancer treatment. Results The majority (81%) of participants indicated that they would consider the use of acupuncture during their cancer treatment. The most common reasons given for not considering acupuncture included adequate control of symptoms already with medical treatment, inconvenient clinic timing, and needle phobia. The main reasons given for considering acupuncture use included its perceived capability of reducing fatigue, boosting energy levels, improving immune function, and reducing pain and anxiety. Patients considering acupuncture use also demonstrated significantly higher levels of stress (p<0.001), anxiety and depression (p<0.001), fatigue (p<0.001), and lower global quality of life (p<0.01) compared to those who were not considering acupuncture. Conclusions The findings show that demand for acupuncture by cancer patients is high. A substantial proportion of cancer patients intend to use acupuncture to manage cancer and/or cancer treatment-related symptoms. Discussion with patients about acupuncture and other complementary therapies during the consultation may improve cancer care.
Juvenile idiopathic arthritis in adulthood: fulfilment of classification criteria for adult rheumatic diseases, long-term outcomes and predictors of inactive disease, functional status and damage
Authors: Oliveira-Ramos Filipa , Eusébio Mónica , M Martins Fernando , Mourão Ana Filipa , Furtado Carolina , Campanilho-Marques Raquel , Cordeiro Inês , Ferreira Joana , Cerqueira Marcos , Figueira Ricardo , Brito Iva , Canhão Helena , Santos Maria José , Melo-Gomes José A , Fonseca João Eurico 
Published: September 2016

ObjectivesTo determine how adult juvenile idiopathic arthritis (JIA) patients fulfil classification criteria for adult rheumatic diseases, evaluate their outcomes and determine clinical predictors of inactive disease, functional status and damage.MethodsPatients with JIA registered on the Rheumatic Diseases Portuguese Register (Reuma.pt) older than 18 years and with more than 5 years of disease duration were included. Data regarding sociodemographic features, fulfilment of adult classification criteria, Health Assessment Questionnaire, Juvenile Arthritis Damage Index—articular (JADI-A) and Juvenile Arthritis Damage Index—extra-articular (JADI-E) damage index and disease activity were analysed.Results426 patients were included. Most of patients with systemic JIA fulfilled criteria for Adult Still's disease. 95.6% of the patients with rheumatoid factor (RF)-positive polyarthritis and 57.1% of the patients with RF-negative polyarthritis matched criteria for rheumatoid arthritis (RA). 38.9% of the patients with extended oligoarthritis were classified as RA while 34.8% of the patients with persistent oligoarthritis were classified as spondyloarthritis. Patients with enthesitis-related arthritis fulfilled criteria for spondyloarthritis in 94.7%. Patients with psoriatic arthritis maintained this classification. Patients with inactive disease had lower disease duration, lower diagnosis delay and corticosteroids exposure. Longer disease duration was associated with higher HAQ, JADI-A and JADI-E. Higher JADI-A was also associated with biological treatment and retirement due to JIA disability and higher JADI-E with corticosteroids exposure. Younger age at disease onset was predictive of higher HAQ, JADI-A and JADI-E and decreased the chance of inactive disease.ConclusionsMost of the included patients fulfilled classification criteria for adult rheumatic diseases, maintain active disease and have functional impairment. Younger age at disease onset was predictive of higher disability and decreased the chance of inactive disease.
Intuitionistic Fuzzy Probabilistic Aggregation Operators Based on the Choquet Integral: Application in Multicriteria Decision-Making
Authors: Sirbiladze Gia , Badagadze Otar 
Published: September 2016

Associated Intuitionistic Fuzzy Probabilistic Averaging (As-IFPA) and Associated Intuitionistic Fuzzy Probabilistic Geometric (As-IFPG) operators based on the Choquet integral and an associated probability class of a fuzzy measure are constructed. Propositions on the correctness of the extensions are proved: (1) The As-IFPA (As-IFPG) operator for the fuzzy measure — capacity of order two coincides with the Intuitionistic Fuzzy Choquet Averaging (Intuitionistic Fuzzy Choquet Geometric) operator; (2) The As-IFPA (As-IFPG) operator coincides with the Intuitionistic Fuzzy Probabilistic Averaging (Intuitionistic Fuzzy Probabilistic Geometric) operator when a probability measure is used in the role of a fuzzy measure. Connections between the constructed operators and the compositions of dual triangular norms [Formula: see text] and [Formula: see text] are constructed. The conjugate connections between the constructed operators are shown. Two illustrative examples on the applicability of the As-IFPA and As-IFPG operators are presented. Several variants of the new operators (1) for the decision-making problem regarding the fiscal policy of a country; (2) for the decision-making problem regarding the best global supplier selection according to the core competencies of suppliers for a manufacturing company are used. Interactions and dependencies among all the combinations of the criteria in the decision-making process are considered.
IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma
Authors: Gao Song , Sun Yan , Zhang Xuebin , Hu Limei , Liu Yuexin , Chua Corrine Yingxuan , Phillips Lynette M. , Ren He , Fleming Jason B. , Wang Huamin , Chiao Paul J. , Hao Jihui , Zhang Wei 
Published: September 2016

Abstract
The molecular basis underlying the particularly aggressive nature of pancreatic ductal adenocarcinoma (PDAC) still remains unclear. Here we report evidence that the insulin-like growth factor–binding protein IGFBP2 acts as a potent oncogene to drive its extremely malignant character. We found that elevated IGFBP2 expression in primary tumors was associated with lymph node metastasis and shorter survival in patients with PDAC. Enforced expression of IGFBP2 promoted invasion and metastasis of PDAC cells in vitro and in vivo by inducing NF-κB–dependent epithelial–mesenchymal transition (EMT). Mechanistic investigations revealed that IGFBP2 induced the nuclear translocation and phosphorylation of the p65 NF-κB subunit through the PI3K/Akt/IKKβ pathway. Conversely, enforced expression of PTEN blunted this signaling pathway and restored an epithelial phenotype to PDAC cells in the presence of overexpressed IGFBP2. Overall, our results identify IGFBP2 as a pivotal regulator of an EMT axis in PDAC, the activation of which is sufficient to confer the characteristically aggressive clinical features of this disease. Cancer Res; 76(22); 6543–54. ©2016 AACR.
How to Deal with Interval-Censored Data Practically while Assessing the Progression-Free Survival: A Step-by-Step Guide Using SAS and R Software
Authors: Dugué Audrey Emmanuelle , Pulido Marina , Chabaud Sylvie , Belin Lisa , Gal Jocelyn 
Published: September 2016

AbstractWe describe how to estimate progression-free survival while dealing with interval-censored data in the setting of clinical trials in oncology. Three procedures with SAS and R statistical software are described: one allowing for a nonparametric maximum likelihood estimation of the survival curve using the EM-ICM (Expectation and Maximization-Iterative Convex Minorant) algorithm as described by Wellner and Zhan in 1997; a sensitivity analysis procedure in which the progression time is assigned (i) at the midpoint, (ii) at the upper limit (reflecting the standard analysis when the progression time is assigned at the first radiologic exam showing progressive disease), or (iii) at the lower limit of the censoring interval; and finally, two multiple imputations are described considering a uniform or the nonparametric maximum likelihood estimation (NPMLE) distribution. Clin Cancer Res; 22(23); 5629–35. ©2016 AACR.