bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation and validation of the Norwegian version of the Coronary Revascularisation Outcome Questionnaire
Authors: Lillevik Siw A , Schroter Sara , Hanssen Tove A 
Published: June 2017

Background: Health-related quality of life (HRQOL) questionnaires are increasingly used as outcome measures in research and clinical practice to assess treatment effectiveness in coronary heart disease (CHD) alongside traditional outcome measures. The Coronary Revascularisation Outcome Questionnaire (CROQ) is a patient-reported outcome measure (PROM) to evaluate health outcomes and HRQOL before and after coronary artery bypass grafting surgery (CABG) and percutaneous coronary intervention (PCI). Aim: To translate the CROQ-PCI from English into Norwegian and test its psychometric properties. Methods: Independent forward and backward translation was done following international guidelines. The CROQ was then pretested with both healthcare professionals and patients before the psychometric properties were field tested in a sample of patients who had undergone PCI. Psychometric testing included an evaluation of: acceptability; tests of scaling assumptions; reliability; content validity; construct validity based on within-scale analyses; and construct validity based on comparisons with external measures. Results: 171 of 258 (66%) invited patients participated. The CROQ was acceptable to patients (low proportion of missing data and good response rate), reliable (good internal consistency and test–retest reliability for all scales), had good content validity (reported by both patients and healthcare professionals) and good construct validity (convergent validity with the SF-12 and Seattle Angina Questionnaire, known groups validity and factor analysis). Conclusion: The Norwegian version of CROQ-PCI is a reliable and valid PROM for assessing HRQOL in CHD patients. Further testing of its responsiveness and ability to detect change is needed before recommending its use in Norwegian clinical practice and research.
Atrial fibrillation and the risk for myocardial infarction, all-cause mortality and heart failure: A systematic review and meta-analysis
Authors: Ruddox Vidar , Sandven Irene , Munkhaugen John , Skattebu Julie , Edvardsen Thor , Otterstad Jan Erik 
Published: June 2017

Abstract

Background
In contemporary atrial fibrillation trials most deaths are cardiac related, whereas stroke and bleeding represent only a small subset of deaths. We aimed to evaluate the long-term risk of cardiac events and all-cause mortality in individuals with atrial fibrillation compared to no atrial fibrillation.

Design
A systematic review and meta-analysis of studies published between 1 January 2006 and 21 October 2016.

Methods
Four databases were searched. Studies had follow-up of at least 500 stable patients for either cardiac endpoints or all-cause mortality for 12 months or longer. Publication bias was evaluated and random effects models were used to synthesise the results. Heterogeneity between studies was examined by subgroup and meta-regression analyses.

Results
A total of 15 cohort studies was included. Analyses indicated that atrial fibrillation was associated with an increased risk of myocardial infarction (relative risk (RR) 1.54, 95% confidence interval (CI) 1.26–1.85), all-cause mortality (RR 1.95, 95% CI 1.50–2.54) and heart failure (RR 4.62, 95% CI 3.13–6.83). Coronary heart disease at baseline was associated with a reduced risk of myocardial infarction and explained 57% of the heterogeneity. A prospective cohort design accounted for 25% of all-cause mortality heterogeneity. Due to there being fewer than 10 studies, sources of heterogeneity were inconclusive for heart failure.

Conclusions
Atrial fibrillation seems to be associated with an increased risk of subsequent myocardial infarction in patients without coronary heart disease and an increased risk of, all-cause mortality and heart failure in patients with and without coronary heart disease.
Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity
Authors: Pick Robert , Begandt Daniela , Stocker Thomas J. , Salvermoser Melanie , Thome Sarah , Böttcher Ralph T. , Montanez Eloi , Harrison Ute , Forné Ignasi , Khandoga Alexander G. , Coletti Raffaele , Weckbach Ludwig T. , Brechtefeld Doris , Haas Rainer , Imhof Axel , Massberg Steffen , Sperandio Markus , Walzog Barbara 
Published: June 2017

Key PointsCoro1A is identified as a novel regulator of β2 integrins (CD11/CD18). Coro1A controls PMN adhesion and postadhesion events in innate immunity.
Predictors, Prognosis, and Management of New Clinically Important Atrial Fibrillation After Noncardiac Surgery: A Prospective Cohort Study
Authors: Alonso-Coello Pablo , Cook Deborah , Xu Shou Chun , Sigamani Alben , Berwanger Otavio , Sivakumaran Soori , Yang Homer , Xavier Denis , Martinez Luz Ximena , Ibarra Pedro , Rao-Melacini Purnima , Pogue Janice , Zarnke Kelly , Paniagua Pilar , Ostrander Jack , Yusuf Salim , Devereaux P. J. ,   on behalf of the POISE Investigators
Published: June 2017

BACKGROUND:
Despite the frequency of new clinically important atrial fibrillation (AF) after noncardiac surgery and its increased association with the risk of stroke at 30 days, there are limited data informing their prediction, association with outcomes, and management.

METHODS:
We used the data from the PeriOperative ISchemic Evaluation trial to determine, in patients undergoing noncardiac surgery, the association of new clinically important AF with 30-day outcomes, and to assess management of these patients. We also aimed to derive a clinical prediction rule for new clinically important AF in this population. We defined new clinically important AF as new AF that resulted in symptoms or required treatment. We recorded an electrocardiogram 6 to 12 hours postoperatively and on the 1st, 2nd, and 30th days after surgery.

RESULTS:
A total of 211 (2.5% [8351 patients]; 95% confidence interval, 2.2%–2.9%) patients developed new clinically important AF within 30 days of randomization (8140 did not develop new AF). AF was independently associated with an increased length of hospital stay by 6.0 days (95% confidence interval, 3.5–8.5 days) and vascular complications (eg, stroke or congestive heart failure). The usage of an oral anticoagulant at the time of hospital discharge among patients with new AF and a CHADS2 score of 0, 1, 2, 3, and ≥4 was 6.9%, 10.2%, 23.0%, 9.4%, and 33.3%, respectively. Two independent predictors of patients developing new clinically important AF were identified (ie, age and surgery). The prediction rule included the following factors and assigned weights: age ≥85 years (4 points), age 75 to 84 years (3 points), age 65 to 74 years (2 points), intrathoracic surgery (3 points), major vascular surgery (2 points), and intra-abdominal surgery (1 point). The incidence of new AF based on scores of 0 to 1, 2, 3 to 4, and 5 to 6 was 0.5%, 1.0%, 3.1%, and 5.3%, respectively.

CONCLUSIONS:
Age and surgery are independent predictors of new clinically important AF in the perioperative setting. A minority of patients developing new clinically important AF with high CHADS2 scores are discharged on an oral anticoagulant. There is a need to develop effective and safe interventions to prevent this outcome and to optimize the management of this event when it occurs.
Postoperative Respiratory Complications in Patients at Risk for Obstructive Sleep Apnea: A Single-Institution Cohort Study
Authors: Ramachandran Satya Krishna , Pandit Jaideep , Devine Scott , Thompson Aleda , Shanks Amy 
Published: June 2017

BACKGROUND:
Obstructive sleep apnea (OSA) is a prevalent condition that is associated with early postoperative respiratory complications (PRCs). As the majority of patients with OSA are undiagnosed, preoperative screening remains the most efficient method to identify suspected OSA.

METHODS:
This retrospective study was performed on patients undergoing anesthesia in a single academic medical center. We assigned OSA risk class retrospectively to all patients in the study by using the Perioperative Sleep Apnea Prediction (PSAP) score. We evaluated the relationship between PSAP categories and early postoperative invasive airway placement after adjusting for several preoperative and intraoperative factors (including surgical risk) previously associated with PRC occurrence.

RESULTS:
A total of 108,479 patients were included in the final analysis with an incidence of PRC was 0.3% (n = 280). High PSAP score was associated with postoperative intubation (adjusted odds ratio, 2.3; 95% confidence interval, 1.5–3.7). Several risk factors reflecting anesthetic agents, neuromuscular blocking agents, and opioids were also independently associated with early PRC.

CONCLUSIONS:
We report that suspected OSA based on the PSAP score is independently associated with increased risk of early PRC. Specific anesthetic agents are independently associated with early PRC, pointing to the potential for examining risk modification through these exposures in future studies.
Optimizing Click-Through in Online Rankings with Endogenous Search Refinement
Authors: De los Santos Babur , Koulayev Sergei 
Published: June 2017

Consumers engage in costly searches to evaluate the increasing number of product options available from online retailers. Presenting the best alternatives at the beginning reduces search costs associated with a consumer finding the right product. We use rich data on consumer click-stream behavior from a major web-based hotel comparison platform to estimate a model of search and click. We propose a method of determining the ranking of search results that maximizes consumers’ click-through rates (CTRs) based on partial information available to the platform at the time of the consumer request, its assessment of consumers’ preferences, and the expected consumer type based on request parameters from the current visit. Our method has two distinct advantages. First, we endogenize a consumer response to the ranking using search refinement tools, such as sorting and filtering of product options. Accounting for these search refinement actions is important since the ranking and consumer search actions together shape the consideration set from which clicks are made. Second, rankings are targeted to anonymous consumers by relating price sensitivity to request parameters, such as the length of stay, number of guests, and day of the week of the stay. We find that predicted CTRs under our proposed ranking are almost double those of the platform’s default ranking. Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1036 .
Technical Note—Multivariate Partial-Expectation Results for Exact Solutions of Two-Stage Problems
Authors: Bansal Saurabh , Dyer James S. 
Published: June 2017

We consider two-stage sequential decision-making problems where in Stage 1 an initial decision is made under a multivariate uncertainty, and in Stage 2 the uncertainty is resolved, a further decision is made based on the uncertainty realization, and the payoff is observed. We focus on problems where the payoff is a linear function of the multivariate uncertainty realization. Such problems can be written as single-stage nonlinear optimization problems composed of partial polyhedral expectations of the multivariate uncertainty. We identify the structural characteristics of multivariate probability density functions under which the integral expressions for the partial expectations can be directly evaluated for an exact value. We then focus on elliptical distributions, which are frequently used in operations management and do have these characteristics. We develop a sequence of three results to determine partial polyhedral expectations of elliptical probability distributions, with a special emphasis on the normal distribution. These results are useful for solving several commonly faced two-stage problems in operations management for an exact solution, performing a comparative static analysis, and rank ordering the alternatives.The online appendix is available at https://doi.org/10.1287/opre.2017.1604 .
Effect of Temperature on Halloysite Acid Treatment for Efficient Chloroaniline Removal from Aqueous Solutions
Authors: Szczepanik Beata , Słomkiewicz Piotr , Garnuszek Magdalena , Rogala Paweł , Banaś Dariusz , Kubala-Kukuś Aldona , Stabrawa Ilona 
Published: June 2017

AbstractMonochloroanilines and dichloroanilines are important reagents or chemical intermediates in the production of dyes, pharmaceuticals, and agricultural chemicals. These toxic compounds have a large tendency to accumulate in the environment and a low natural biodegradability, so improved methods to remove or sequester them are needed. Halloysite is used as an efficient adsorbent to remove toxic compounds, such as aniline, from aqueous solutions. The purpose of this study was to evaluate whether acid-activated halloysites from the “Dunino” (Poland) strip mine could be effective in the removal of not just aniline but also of its chloro-substituted forms from aqueous solutions. The composition, structure, and morphology of activated halloysites were characterized using the following methods: wavelength dispersive X-ray fluorescence analysis (WDXRF), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), and N2 adsorption-desorption analysis. The acidactivated halloysites had an increased ability to remove aniline and chloroanilines from aqueous solutions as the acid activation temperature was increased. This suggests that the acid activation temperature is an important factor that influences the ability of acid activated halloysites to adsorb aromatic amines (anilines) from water. The efficiency of aniline and chloroaniline removal by halloysite activated at 80°C reached maximum levels, especially for the removal of aniline and 4-chloroaniline. The adsorption isotherm data were best described by the Langmuir adsorption model. The values of the Langmuir adsorption constants were calculated using the inverse liquid chromatography method.
Comparision of the motivational factors for participating in to sports festival with respect to some demographical variables and two different run years: RUNATOLIA case<p>Bireyleri spor festivaline katilmaya motive eden faktörlerin çeşitli demografik değişkenlere ve yillara göre karşilaştirilmasi: RUNATOLIA’ya örneği
Authors: Ardahan Faik , Çalışkan Alaattin 
Published: June 2017

The purpose of this study; is the comparisons of the motivational factors for participating sport festival in RUNTALIA case with respect to some demographic variables and two different run years.The study was descriptive and the universe is the participatns who want to run in 2015 and 2016 race.The sampling method for 2015 was convenience sampling and sampling consisted of 276 volunteer The sampling group of 2016-race was consisted of 432 volunteer participants who accept filling questionnaire when making application in to Official WEB sites of Runatolia among 9863 total participants.The questionnaire form consisted of two main part; first demographics variables and second “The Motivational Factors Scale for Participating Sport Festival- SFKMÖ” developed by Ardahan and Çalışkan. While face to face survey method in 2015, electronic survey method used in 2016.As a result, it can be concluded that, even if there were statistically meaningful difference in the motivational factors for participating in RUNTALIA with respect to some demographics variables between 2015 and 2016 race, the first three sub dimensions were same “Physical Activity”, “Fun/Pleasure” and “novelty”.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetAraştırmanın amacı; Bireyleri Spor Festivallerine Katılmaya Motive eden faktörlerin RUNATOLIA örneğinde çeşitli demografik değişkenlere göre ve yıllara göre karşılaştırılmasıdır. Araştırma tanımlayıcı bir araştırmadır. Ana kütle 2015 ve 2016 yılında yarışmaya başvuran kişilerden oluşmaktadır. 2015 yılı örneklemi kolay örnekleme yöntemiyle belirlenmiş 276 kişiden oluşurken, 2016 yılı örneklemi, katılımcıların etkinliğe Runatolia Kurumsal WEB adresi üzerinden başvurduğu sırada isteyen katılımcıların doldurabilecekleri elektronik anketi dolduran 432 kişiden oluşmaktadır.Verilerin toplanmasında demografik bilgiler ve Ardahan ve Çalışkan tarafından geliştirilen “Bireyleri Spor Festivallerine Katılmaya Motive Eden Faktörler Ölçeği (SFKMÖ)” nin yer aldığı anket formu kullanılmıştır. 2015 yılında anket yüzyüze uygulanırken, 2016 yılında elektronik anket formu kullanılmıştır. Sonuç olarak; 2015 ve 2016 yılları çeşitli demografik değişkenlere göre karşılaştırıldığında SFKMÖ alt boyutlarında istatistiki olarak anlamlı farklılık olsa da yıllar itibariyle RUNATOLIA’ya katılım gerekçeleri önceliği sıralamasında (Fiziksel Aktivite, Eğlence ve Yenilik) her hangi bir değişiklik olmamıştır.
Pengaruh Land Subsidence terhadap Genangan Banjir dan Rob di Semarang Timur
Authors: Pujiastuti Ratih , Suripin Suripin , Syafrudin Syafrudin 
Published: June 2017

Inundation of flood and rob (flood due to high tides) in Semarang City is increase wtithin area and depth. It be more seroius condition because of land subsisdence that happened in coastal area of Semarang City. This research is foccused on prediction and mapping of inundation flood and rob due to land subsidence effect in East Semarang, especially Tenggang Watershed and Sringin Watershed. On this research, data analysis including analysis of land subsidence, analysis of hydrological data, analysis of flood discharge with HEC-HMS, hydraulics analysis with HEC-RAS and then mapping the results of the flood inundation with Arc GIS. The inundation will be create with overlay the DEM of flood water level and DEM of topographic. According to the results of analysis is known that minimum land subsidence is 0 cm/year that happened in south area of Semarang and more higher ini north area with maximum land subsidence is 5.58 cm/year. On periode 2014-2031, the contribute of land subsidence to increase the inundation of flood and rob is 1.39%/year.
Unjuk Kerja Waduk Jatigede
Authors: Cholifatul Afifah Risdiana , Samto Atmodjo Pranoto , Sangkawati Sri 
Published: June 2017

Jatigede Reservoir located in Sumedang, West Java. As the second largest reservoir in Indonesia, the main purpose of the reservoir construction is to irrigate the 90.000 Ha of irrigation area, the source of 3,5 m3/s of raw and drinking water, as well as the source of water for hydropower plan Jatigede requiring water supply as much as 61,84 m3/s. One of the efforts that can be taken to optimize reservoir of water resources, particularly for irrigation water needs, is to do a simulation model of the Jatigede Reservoir operation. This study is discusses the analysis of the performance of the operating pattern Jatigede were analyzed based on the stochastic model of Cimanuk river flow and rain data of Cimanuk Water District. Data needs to be tested first to qualify for a normal statistical distribution using AProb software version 4.1. Stochastic models were analyzed with software SAMS 2007 from Colorado State University. Surgery simulation analysis to determine the performance of the reservoir using software Ribasim. To test the performance of reservoir used the criteria of reliability, resilience, and vulnerability. From the analysis of performance can be concluded that the reliability of the reservoir in an effort to meet the needs of raw water, irrigation, and hydropower at existing condition is of 98.3%, the resilience of the reservoir by 50%, and the vulnerability of dams throughout the simulation period amounted to 6824.70 m3/s , While in the next 50 years the condition of the dam by 92.7% reliability, resilience reservoir by 34%, and the vulnerability of dams throughout the simulation period amounted 20.540,51m3/s. It can be concluded that the performance of Jatigede reservoir decreased after the analysis of reservoir operation plan for the next 50 years.
Hegel und die Moderne
Authors: Arndt Andreas , Gerhard Myriam , Zovko Jure , Arnautović Samir , Preljević Vahidin 
Published: June 2017

ZusammenfassungVom 15. bis 19. September 2010 fand in Sarajevo (Bosnien und Herzegovina) der XXVIII. Internationale Hegel-Kongress der Internationalen Hegel-Gesellschaft zum Thema „Hegel und die Moderne” statt. Der Band dokumentiert den ersten Teil der dort gehaltenen Plenar- und Sektionsvorträge zu den thematischen Schwerpunkten: Hegels Begriff der Moderne, Subjektivität und Individualität, Staat, Recht und Gesellschaft, Religion sowie Kunst.Mit Beiträgen u.a. von Eduardo Álvarez (Madrid), Samir Arnautovic (Sarajevo), Claudia Bickmann (Köln), Gilles Campagnolo (Aix-en-Provence), Paul Cruysberghs (Leuven), Ingolf Dalferth (Zürich), Giovanno Gerardi (Gorgonzola), Aliki Lavranu (Rethymnon), Yoshihiro Niji (Osaka), Pedro Novelli (São Manuel, Brasilien), Andrzej Przylebski (Poznan), Erzsebet Rózsa (Debrezen), Alberto Siani (Pisa), Pirmin Stekeler-Weithofer (Leipzig) und Violetta Waibl (Wien).
High‐affinity cooperative Ca2+ binding by MICU1–MICU2 serves as an on–off switch for the uniporter
Authors: Kamer Kimberli J , Grabarek Zenon , Mootha Vamsi K 
Published: June 2017

AbstractThe mitochondrial calcium uniporter is a Ca2+‐activated Ca2+ channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca2+ signals. It is regulated by two paralogous EF‐hand proteins—MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate that both MICU1 and MICU2 are stabilized by Ca2+. We reconstitute the MICU1–MICU2 heterodimer and demonstrate that it binds Ca2+ cooperatively with high affinity. We discover that both MICU1 and MICU2 exhibit affinity for the mitochondria‐specific lipid cardiolipin. We determine the minimum Ca2+ concentration required for disinhibition of the uniporter in permeabilized cells and report a close match with the Ca2+‐binding affinity of MICU1–MICU2. We conclude that cooperative, high‐affinity interaction of the MICU1–MICU2 complex with Ca2+ serves as an on–off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca2+ signals.
Maternal Haploid, a Metalloprotease Enriched at the Largest Satellite Repeat and Essential for Genome Integrity in Drosophila Embryos
Authors: Tang Xiaona , Cao Jinguo , Zhang Liang , Huang Yingzi , Zhang Qianyi , Rong Yikang S 
Published: June 2017

Abstract
The incorporation of the paternal genome into the zygote during fertilization requires chromatin remodeling. The maternal haploid (mh) mutation in Drosophila affects this process and leads to the formation of haploid embryos without the paternal genome. mh encodes the Drosophila homolog of SPRTN, a conserved protease essential for resolving DNA–protein cross-linked products. Here we characterize the role of MH in genome maintenance. It is not understood how MH protects the paternal genome during fertilization, particularly in light of our finding that MH is present in both parental pronuclei during zygote formation. We showed that maternal chromosomes in mh mutant embryos experience instabilities in the absence of the paternal genome, which suggests that MH is generally required for chromosome stability during embryogenesis. This is consistent with our finding that MH is abundantly present on chromatin throughout the cell cycle. Remarkably, MH is prominently enriched at the 359-bp satellite repeats during interphase, which becomes unstable without MH. This dynamic localization and specific enrichment of MH at the 359 repeats resemble that of Topoisomerase 2 (Top2), suggesting that MH regulates Top2, possibly as a protease for the resolution of Top2-DNA intermediates. We propose that maternal MH removes proteins specifically enriched on sperm chromatin. In the absence of that function, paternal chromosomes are precipitously lost. This mode of paternal chromatin remodeling is likely conserved and the unique phenotype of the Drosophila mh mutants represents a rare opportunity to gain insights into the process that has been difficult to study.