bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyaniline‐Doped Textile‐Based Triboelectric Nanogenerator: Self‐Powered Device for Wearable Electronics
Authors: Amini Sebghatullah , Sagade Muktar Ahmed Rumana Farheen , Madanahalli Ankanathappa Sangamesha , Sannathammegowda Krishnaveni 
Published: October 2024

ABSTRACTThe emergence of wearable electronics in contemporary lifestyles has spurred the need for smart fabrics capable of harnessing biomechanical energy. In the present study, a flexible polyaniline‐doped textile‐based triboelectric nanogenerator (PT‐TENG) is designed to harvest low‐frequency mechanical vibrations and convert them into electricity. For the device fabrication, five different textile fabrics are doped with conducting PANI, which is utilized as the tribopositive material, PVC thin film as the tribonegative material, and Al foil as electrodes. The PT‐TENG works in vertical‐contact separation mode, devised in arch structure for easy and complete contact between the working layers. Interestingly, the device featuring a PANI‐doped silk fabric generated the highest output voltage of 257.68 V and a current of 5.36 μA, respectively. Additionally, the PT‐TENG exhibits mechanical durability and electrical stability during continuous 7000 cyclic operations. Furthermore, the PT‐TENG showcases practical applications such as charging commercial capacitors, powering green LEDs and smartwatches, and as a self‐powered touch sensor. Thus, the PT‐TENG offers a facile fabrication process and robustness, highlighting its potential for sustainable energy harvesting in wearable electronics.
Genetic Analysis of Asymptomatic Antinuclear Antibody Production
Authors: Hocaoǧlu Mehmet , Casares‐Marfil Desiré , Sawalha Amr H. 
Published: October 2024

ObjectiveAntinuclear antibodies (ANA) are detected in up to 14% of the population, and many individuals with ANA are asymptomatic. The literature on the genetic contribution to asymptomatic ANA positivity is limited. In this study, we aimed to perform a genome‐wide association study of asymptomatic ANA positivity in multiple populations.MethodsAsymptomatic individuals who were either ANA positive or ANA negative from the All of Us Research Program were included in this study, selecting those with an ANA test performed by immunofluorescence and no evidence of autoimmune disease. Imputation was performed, and a multipopulation meta‐analysis including approximately 6 million single‐nucleotide polymorphisms (SNPs) was conducted. Genome‐wide SNP‐based heritability was estimated using the Genome‐wide Complex Trait Analysis software. A cumulative genetic risk score for lupus was constructed using previously reported genome‐wide significant loci.ResultsA total of 1,955 asymptomatic ANA positive and 3,634 asymptomatic ANA negative individuals across three populations were included. The multipopulation meta‐analysis revealed SNPs with a suggestive association (P <1 × 10−5) across 8 different loci, but no genome‐wide significant loci were identified. A gene variant upstream of HLA‐DQB1, (rs17211748, P = 1.4 × 10−6, odds ratio 0.82, 95% confidence interval 0.76–0.89), showed the most significant association. The heritability of asymptomatic ANA positivity was estimated to be 24.9%. Individuals who were asymptomatic and ANA positive did not exhibit increased cumulative genetic risk for lupus compared with individuals who were ANA negative.ConclusionANA production is not associated with significant genetic risk and is primarily determined by environmental factors.image
Evidence of Site‐Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis
Authors: Derksen Veerle F. A. M. , Martinsson Klara , van Mourik Anouk G. , Wagenaar Carlijn A. , Toes René E. M. , Walrabenstein Wendy , Sjöberg Daniel , van Schaardenburg Dirkjan , Huizinga Tom W. J. , Kastbom Alf , Svärd Anna , van der Woude Diane 
Published: October 2024

ObjectiveAnti–citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti–modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined. We therefore investigated the presence of several AMPA (ACPA, anti–carbamylated protein antibodies [anti‐CarP], and anti–acetylated protein antibodies [AAPA]) at different mucosal sites, including the intestinal tract.MethodsPaired fecal/ileal wash, saliva, and serum samples of patients with RA and healthy volunteers were collected in two independent cohorts. Data involving feces were replicated in a third cohort. In these secretions, AMPA were analyzed using in‐house enzyme‐linked immunosorbent assay with unmodified peptides as control. In fecal samples, total IgA and anti–Escherichia coli IgA were measured.ResultsACPA, anti‐CarP, and AAPA IgA were measurable in saliva of seropositive patients with RA (prevalence 9%–40%). No AMPA could be detected in feces. IgA was present because total IgA and anti–E. coli IgA were detectable in feces of ACPA‐positive patients with RA and healthy donors. Results were confirmed in another cohort using colonoscopically collected ileal wash samples.ConclusionOur study shows the presence of ACPA, anti‐CarP, and AAPA IgA in saliva of ACPA‐seropositive patients with RA. However, no AMPA could be detected in feces/ileal wash samples of these patients, although our assays were able to measure other antigen‐specific antibodies. These data suggest that mucosal autoantibody secretion may occur in the oral mucosa of patients with RA, whereas no evidence could be found for this process in the lower gastrointestinal tract.
Glassy Carbon Electrodes Modified with Ru Nanoparticles Loaded in B‐Doped Imidazolium Porous Organic Polymers for Hydrogen Evolution Reaction
Authors: Ma Shasha , Chen Di , Xu Jie , Ye Zhaobin , Zhang Jianyong 
Published: October 2024

AbstractPorous organic polymers (POPs) are a type of porous material composed of organic structural units connected by covalent bonds and POPs have been used as efficient electrocatalysts for hydrogen evolution reaction (HER). Herein, glassy carbon electrode (GCE) is chemically modified by B‐doped imidazolium‐based porous organic polymers loaded with Ru nanoparticles on the GCE surface. The incorporation of B in the POPs regulates the electronic structure of electrocatalysts to enhance their inherent electrocatalytic activity for HER. The optimized modified electrode GCE‐Ru/PIM‐Br2 exhibits a low overpotential of 271 mV at a current density of 10 mA cm−2 with a small Tafel slope (80 mV dec−1) in acidic solutions, and shows long‐term stability for up to 22 h. This work presents a strategy to develop B‐doped porous electrodes with loaded metal nanoparticles to strengthen the catalytic performance of electrocatalysts.
Early oncological outcomes of delayed radical prostatectomy: A prospective, international, follow‐up analysis of the COVIDSurg‐Cancer study
Authors: Nathan Arjun , Gao Chuanyu , Light Alexander , Alexander Cameron , Chan Vinson , Gallagher Kevin , Khadhouri Sinan , Byrnes Kevin G. , Ng Michael , Walters Michael , Hughes Terry , Perry Rita J. , Okoth Kelvin , Magill Laura , Pinkney Thomas , Zhang Yuhao , Blackmur James , Etchill Eric , Tang Stanley , García Escudero Damián , McNeill Alan , Narahari Krishna , Stewart Grant D. , Kasivisvanathan Veeru ,   COVIDSurg Collaborative
Published: October 2024

AbstractObjectivesThe objective of this study is to compare the early oncological outcomes of delayed (>90 days) versus scheduled (≤90 days) radical prostatectomy (RP).Patients and methodsPatients with prostate cancer due to undergo surgery between March 2020 and June 2020 who were enrolled in the COVIDSurg‐Cancer international, observational study were prospectively followed up for 1 year. Time to surgery was defined as the difference between the operation date and the multi‐disciplinary team decision to offer surgery. The primary outcome was the positive surgical margin (PSM) rate. Biochemical recurrence (BCR), upgradation and upstaging were secondary oncological outcomes. The Independent t‐test and Mann Whitney U test were used to compare means between groups and regression models and were used to investigate factors associated with the primary outcome.ResultsFour hundred seventy‐six (78.7%) patients underwent RP from 605 that were eligible. Three hundred seven (64.5%) patients underwent scheduled RP, and 169 (35.5%) underwent delayed RP. A small proportion of men (n = 35, 6.8%) did not undergo RP within the 1‐year follow‐up period. More men with high‐risk disease (72.8%) underwent scheduled RP compared to men with intermediate‐risk disease (60.2%) (p < 0.05). There was no statistically significant difference in the PSM rate between the two groups (p = 0.512). Delay in surgery was not associated with an increased PSM or BCR on univariable or multivariable analyses. There was statistically significantly greater upstaging (p < 0.05) in the delayed group but no difference in upgradation.ConclusionHigh‐risk men were prioritised for surgery during the COVID‐19 pandemic. Our prospective data support previous retrospective, cancer‐registry evidence suggesting no adverse oncological impact after delaying RP across all risk groups. Our study is limited by the short follow‐up period, and therefore, longer term conclusions cannot be drawn.
Assessing circularity and sustainability of a value chain: A systematic literature review
Authors: Esteban‐Amaro Rosa , Estelles‐Miguel Sofia , Lengua Ismael , Yannou Bernard , Bouillass Ghada 
Published: October 2024

AbstractValue chains have become increasingly complex, complicating the transition to a circular economy and the pursuit of sustainable development. This transition requires assessing economic, environmental, social, and governance dimensions. We conduct a systematic literature review to evaluate whether existing methodologies can effectively assess the circularity and sustainability of value chains according to these four critical dimensions. Our work identifies three critical aspects to improve value chain evaluation: (i) circular economy requires assessment of the entire value chains, (ii) lack of stakeholder integration hinders sustainable development, and (iii) the need for multilevel and multidimensional performance assessment results in complex and incomplete methodologies. These findings imply that restructuring value creation models and value chain networks is essential to facilitate the application of simplified methodologies, thereby promoting the widespread adoption of circularity and sustainability. Addressing these gaps would the achievement of the 2030 Sustainable Development Agenda and benefit society in the long run.
Development and validation of the NCC‐BC‐A scale to assess patient‐reported outcomes for breast cancer patients in China
Authors: Ma Fei , Yan Xiaoyan , Guan Xiuwen , Liu Tianmou ,   PRO‐BC China Standards Committee
Published: October 2024

AbstractBackgroundThe commonly used international patient‐reported outcome scales for breast cancer were developed before the advent of multiple targeted therapies and immunotherapies, rendering them potentially insufficient for current clinical practices. Therefore, it is necessary to develop a specific patient‐reported outcome scale tailored for breast cancer patients in China to optimize the management model for these patients.MethodsA comprehensive literature search was performed in the PubMed, Embase, Wanfang, and CNKI databases to extract dimensions and items for a potential patient‐reported outcome scale. The Delphi method was used to modify, add, subtract, and adjust the language of items until the experts reached a consensus on the first draft. This draft was further refined using a cognitive test and a presurvey. The optimized scale was used for a formal survey, and the items were further analyzed and screened using metrics such as the coefficient of variation, correlation coefficient, internal item consistency, factor analysis, reliability, and validity.ResultsA total of 10,954 articles were analyzed, and 237 were used to create a pool of 277 patient‐reported outcome items. Through two rounds of Delphi expert consultation, the experts' authority coefficients were 0.739 and 0.826. After a cognitive test, several items were adjusted to enhance understanding. Further adjustments were made following a presurvey of 200 advanced breast cancer patients, resulting in a 38‐item patient‐reported outcomes scale, termed NCC‐BC‐A. In the national formal survey, 588 advanced breast cancer patients participated. Principal component analysis showed good consistency among the items and sufficient difference between the dimensions. The results were normally distributed with good variation. The Cronbach's α coefficient of the scale was 0.925 and the test–retest reliability was 0.9041.ConclusionThe NCC‐BC‐A scale has high validity and reliability. It comprehensively considered the characteristics of systemic treatment for breast cancer, and the specific context within China. Its implementation may help clinicians to pay more attention to quality of life of breast cancer patients and to optimize the system for managing this condition.
What Do We Know About Capsicum Volatilome?
Authors: Ithaí Ángeles‐López Yesenia , José Martínez‐Cano David , Villa‐Ruano Nemesio 
Published: October 2024

AbstractThe Capsicum genus includes several cultivated species that release complex blends of volatile organic compounds (VOCs) associated with their unique aroma. These VOCs are essential info‐chemicals in ecological interactions. In this review, we describe how the volatilomic profiling naturally varies based on specific plant organs and genotypes as well as how non‐beneficial organisms affect VOCs biosynthesis and accumulation in pepper plants. Also, we show evidence about VOCs variation under the pressure of different abiotic factors such as water stress, soil type and nutrient availability. The contribution of specific metabolic pathways and gene expression related to the biosynthesis of particular VOCs is addressed. We highlighted the utility of VOCs as chemical markers for quality control in the food industry, breeding programs to generate resistant plants and to improve aroma innovation. Herein we present a database containing 2734 VOCs, revealing 113 as the basic core of the volatilome from five Capsicum species.
Degradation Polysaccharides from Benincasa hispida var. chieh‐qua How: Unveiling Bioactive Properties of Degraded Compounds
Authors: Sheng Xin‐Yuan , Zhang Hai‐Jiang , Chen Xin‐Juan , Wang Kui‐Wu 
Published: October 2024

AbstractThis study reported an effective method for the degradation of Chieh‐qua (Benincasa hispida var. Chieh‐qua How) polysaccharides (BHCP) by a hydrogen peroxide‐ascorbic acid oxidation (H2O2‐VC) system. The degradation conditions were optimized using a Box‐Behnken response surface design as concentration of H2O2‐VC 19.5 mM, degradation temperature 46.4 °C and degradation time 1.0 h. The average molecular weight was decreased and total sugar content was raised of the degraded polysaccharide (DBHCP). Two refined degraded polysaccharides (DBHCP‐1, DBHCP‐2) were purified and prepared, and their structures were analyzed by chemical and spectral analysis. The in vitro experiments showed that degraded polysaccharides (DBHCP and DBHCP‐1) have better antioxidant and anti‐tyrosinase activity than natural polysaccharide BHCP. These findings support the potential application of Chieh‐qua polysaccharides in the food and medical industries.
A recurrent typical angina pectoris without any finding in coronary angiography: Microvascular angina
Authors: Taheri Homa , Taheri Maryam , Ebrahimi Pouya , Soltani Parnian , Zadeh Amin Zaki , Anafje Mohsen 
Published: October 2024

Key Clinical MessageMicrovascular angina (MVA) can present with recurrent chest pain and normal coronary angiography. Recognizing MVA is crucial as it significantly impacts patient morbidity and mortality. Early diagnosis and management with antianginal medications are essential for improving outcomes and quality of life.AbstractCardiovascular diseases are still the main cause of death in many parts of the world. Chest pain and dyspnea are always concerning due to the implications of cardiovascular disease. However, in patients with the involvement of the small coronary vessels (Microvascular Angina), symptoms might be recurrent and persistent despite the presence of normal coronary vessel evaluations. A 45‐year‐old man with a 25‐year smoking history presented with recurrent chest pain, especially during physical activity, and mild shortness of breath. He was admitted, and a coronary angiography the next day appeared normal. However, a cardiac PET scan revealed the involvement of small coronary vessels not visible on angiography. The Patient was a 45‐year‐old man who presented with recurrent chest pain, more prominent during physical activity. He also had mild shortness of breath. The patient was admitted, and the next day, he underwent normal coronary angiography. The cardiac positron emission tomography (PET scan) showed the involvement of small coronary vessels that were not obvious on angiography.
Hypocalcemia‐induced seizures in a peritoneal dialysis (PD) patient: A case report
Authors: Taha Mohammed , Azhary Ayman , Ahmed Abdallah Elssir , Abdelbagi Abubakar , Hamida Mohammed Elfatih , Ournasseir Mohammed Elfatih Hussein 
Published: October 2024

Key Clinical MessageA thorough evaluation is necessary for seizures caused by hypocalcemia, both during the patient's presentation and following their recovery from the postictal seizure episode. This is because the underlying cause of hypocalcemia must be ruled out in order to ensure the best possible clinical outcome from calcium and vitamin D therapy.AbstractPatients with multiple systemic issues, including neurological involvement and seizure development, are not uncommon among nephrologists. Both the central and peripheral neural systems can be impacted by kidney disease. The main symptoms are myopathy, cranial or peripheral neuropathy, cognitive impairment, and seizures. A 22‐year‐old female with an unusual medical history who had been known to have end‐stage kidney disease (ESKD) for a year and regularly had CAPD (continuous ambulatory peritoneal dialysis) suffered from two episodes of tonic‐colonic seizures 2 weeks apart. On physical examination, symptoms of tongue biting, decreased vision in the left eye, and mild bilateral pulmonary air entry were notable. Upon examination, there was evidence of severe hypocalcemia, hyponatremia, a high renal profile (urea and creatinine), anemia, and a severe vitamin D deficiency. Her peritoneal dialysis (PD) prescription was reviewed, her seizures ceased, and she was released from the hospital after the hypocalcemia was treated with intravenous calcium and high doses of vitamin D. The issue of hypocalcemic seizures should be carefully evaluated both at the presentation and after the patient recovers from the postictal stage. By following this, seizure episodes can be prevented with good success if patients strictly adhere to the medication for which they are responsible.
Targeted and Untargeted Amine Metabolite Quantitation in Single Cells with Isobaric Multiplexing
Authors: Heininen Juho , Movahedi Parisa , Kotiaho Tapio , Kostiainen Risto , Pahikkala Tapio , Teppo Jaakko 
Published: October 2024

AbstractWe developed a single cell amine analysis approach utilizing isobarically multiplexed samples of 6 individual cells along with analyte abundant carrier. This methodology was applied for absolute quantitation of amino acids and untargeted relative quantitation of amines in a total of 108 individual cells using nanoflow LC with high‐resolution mass spectrometry. Together with individually determined cell sizes, this provides accessible quantification of intracellular amino acid concentrations within individual cells. The targeted method was partially validated for 10 amino acids with limits of detection in low attomoles, linear calibration range covering analyte amounts typically from 30 amol to 120 fmol, and correlation coefficients (R) above 0.99. This was applied with cell sizes recorded during dispensing to determine millimolar intracellular amino acid concentrations. The untargeted approach yielded 249 features that were detected in at least 25 % of the single cells, providing modest cell type separation on principal component analysis. Using Greedy forward selection with regularized least squares, a sub‐selection of 100 features explaining most of the difference was determined. These features were annotated using MS2 from analyte standards and accurate mass with library search. The approach provides accessible, sensitive, and high‐throughput method with the potential to be expanded also to other forms of ultrasensitive analysis.
Recent Advances in Methodologies for Radical‐Mechanistic Borylation†
Authors: Lian Chang , Zhang Jianning , Qiu Di , Mo Fanyang 
Published: October 2024

Comprehensive SummaryWe reviewed works on radical borylation reactions since 2020 from two aspects. 1. Borylation from alkyl or aryl radicals: This approach involves the generation of alkyl or aryl radicals from various precursors such as halides and carboxylic acids, followed by their reaction with diboron reagents to form boron esters. 2. Borylation from boron‐centered radicals: This approach involves generating boron‐centered radicals, which then react with substrates to achieve borylation.
Key Scientists
Ytterbium‐Catalyzed Tandem Diels–Alder/Claisen Rearrangement/Decarboxylation of Hetero‐Allenes for the Synthesis of Diarylmethanes
Authors: Chen Bin , Zhong Shan , Zhan Huilin , Han Zhangyu , Sun Jianwei , Huang Hai 
Published: October 2024

Comprehensive SummaryA tandem Diels–Alder reaction/Claisen rearrangement/decarboxylation strategy of N‐allenamides (or aryloxyallenes) with 3‐alkoxycarbonyl‐2‐pyrones has been developed for the efficient synthesis of diarylmethanes with moderate to good yields. The reaction exhibits good functional group tolerance and can be applied to late‐stage modifications of known drug molecules. Mechanistic studies indicate that the ester group at the 3‐position of 2‐pyrones is essential, and the initial Diels–Alder reaction between the 2‐pyrones and the proximal C=C bond of the N‐allenamides (or aryloxyallenes) is crucial for the success of the reaction.
FSscore: A Personalized Machine Learning‐Based Synthetic Feasibility Score
Authors: Neeser Rebecca M. , Correia Bruno , Schwaller Philippe 
Published: October 2024

AbstractDetermining whether a molecule can be synthesized is crucial in chemistry and drug discovery, as it guides experimental prioritization and molecule ranking in de novo design tasks. Existing scoring approaches to assess synthetic feasibility struggle to extrapolate to new chemical spaces or fail to discriminate based on subtle differences such as chirality. This work addresses these limitations by introducing the Focused Synthesizability score (FSscore), which uses machine learning to rank structures based on their relative ease of synthesis. First, a baseline trained on an extensive set of reactant‐product pairs is established, which is then refined with expert human feedback tailored to specific chemical spaces. This targeted fine‐tuning improves performance on these chemical scopes, enabling more accurate differentiation between molecules that are hard and easy to synthesize. The FSscore showcases how a human‐in‐the‐loop framework can be utilized to optimize the assessment of synthetic feasibility for various chemical applications.