bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addiction Treatment Ultimatums and U.S. Health Reform: A Case Study
Authors: Weisner Constance , Hinman Agatha , Lu Yun , Chi Felicia W. , Mertens Jennifer 
Published: December 2017

■ AIMS Increased access to health care, including addiction treatment, has long been a goal of health reform in the U.S. An unanswered question is whether reform will change the way people get to addiction treatment; when treatment is easily accessible, do individuals self-refer, or do they still enter treatment via ultimatums, and if so, from which sources? To begin examining this, we used a single case study of a U.S. health plan that provides access similar to that called for in health reform. ■ METHOD Using a case study method of data from studies conducted in a large, private non-profit, integrated managed care health plan which includes addiction services, we examined the prevalence and source of ultimatums to enter treatment, and the characteristics of those receiving them. The plan is highly representative of changes to U.S. health care and other countries due to health reform. ■ RESULTS Many individuals entering addiction treatment had received an ultimatum stemming from employment, legal, medical, and family sources. Having more employment problems, an occupation with public safety concerns, being older, male, and ethnicity predicted an employment ultimatum. Higher legal problem severity predicted a legal ultimatum. More men (and younger people) had family ultimatums, and more women (and older people) had medical ultimatums. Being younger, male, married, having higher employment and family problem severity, and being drug or combined drug/alcohol dependent rather than dependent on alcohol-only predicted an ultimatum from one's family. On the whole, an ultimatum from one source was not related to having one from another source. Those most likely to receive ultimatums from multiple sources were women, those separated/divorced, and those having higher psychiatric and legal problem severity. ■ CONCLUSIONS Even in an insured population with good access to addiction treatment, individuals often receive ultimatums to enter treatment rather than being self-referred. Understanding the treatment entry process, and how it is affected by health care systems, could benefit from international and other comparative research.
Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice
Authors: Lang Julie , Zhang Bicheng , Kelly Margot , Peterson Jacob N. , Barbee Jacob , Freed Brian M. , Di Santo James P. , Matsuda Jennifer L. , Torres Raul M. , Pelanda Roberta 
Published: December 2017

Key PointsExpression of full-length hBAFF from cDNA in the endogenous murine locus does not improve maturation of human B cells in hu-mice. mBAFF is not limiting the maturation of human B cells in hu-mice.
An autonomic hierarchical reliable broadcast protocol for asynchronous distributed systems with failure detection
Authors: Jeanneau Élise , Rodrigues Luiz A. , Arantes Luciana , Duarte Elias P. 
Published: December 2017

Abstract
Reliable broadcast is a fundamental building block in fault-tolerant distributed systems. It consists of a basic primitive that provides agreement among processes of the system on the delivery of each broadcast message, i.e., either none or all correct processes deliver the message, despite failures of processes. In this work, we propose a reliable broadcast solution on top of VCube, assuming that the system is asynchronous. VCube is an autonomic monitoring layer that organizes processes on a hypercube-like overlay which provides several logarithmic properties even in the presence of processes failures. We consider that processes can fail by crashing, do not recover, and faults are eventually detected by all correct processes. The protocol tolerates false suspicions by sending additional messages to suspected processes but logarithmic properties of the algorithm are still kept. Experimental results show the efficiency of the proposed solution compared to an one-to-all strategy.
Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up
Authors: Bugter Oisín , Monserez Dominiek André , van Zijl Floris Vincent Willem Joseph , Baatenburg de Jong Robert Jan , Hardillo Jose Angelito 
Published: December 2017

Background Our aim was to review our management of inverted papilloma (IP), perform a recurrence analysis, and review the literature. Methods A retrospective analysis of 247 patients treated for an IP. Patients were grouped according to surgical approach, tumor presentation (primary, residual and recurrence) and Krouse-stage. Results Recurrence was observed in 20.3%, 28.6% and 35.1% ( p = 0.017) of the patients who underwent endoscopic, external and combined surgery, respectively. Recurrences occurred more often in residual than primary IP (36.9% vs. 22.3%, p = 0.021). Primary endoscopic surgery had a recurrence rate of 12.5%, which was comparable to the recent literature (11.2%, 161/1433). Conclusions The relatively high number of recurrences in this cohort is explained by the long follow-up and previous (incomplete) surgery in 61.5% of the cases. The inferior outcome of residual IP underscores the importance of having a low threshold for preoperative biopsy in unilateral and atypical sinonasal disease.
Continuous Noninvasive Arterial Pressure Monitoring Using the Vascular Unloading Technique (CNAP System) in Obese Patients During Laparoscopic Bariatric Operations
Authors: Rogge Dorothea E. , Nicklas Julia Y. , Haas Sebastian A. , Reuter Daniel A. , Saugel Bernd 
Published: December 2017

BACKGROUND:
Increasing rates of obesity create new challenges for hemodynamic monitoring in the perioperative phase. Continuous monitoring of arterial pressure (AP) is important in severely obese patients who are at particular risk for cardiovascular complications. Innovative technologies for continuous noninvasive AP monitoring are now available. In this study, we aimed to compare continuous noninvasive AP measurements using the vascular unloading technique (CNAP system; CNSystems, Graz, Austria) compared with invasive AP measurements (radial arterial catheter) in severely obese patients during laparoscopic bariatric surgery.

METHODS:
In 29 severely obese patients (mean body mass index 48.1 kg/m2), we simultaneously recorded noninvasive and invasive AP measurements over a period of 45 minutes and averaged the measurements using 10-second episodes. We compared noninvasive (test method) and invasive (reference method) AP measurements using Bland-Altman analysis and 4-quadrant plot/concordance analysis (2-minute interval).

RESULTS:
We observed a mean of the differences (±SD, 95% limits of agreement) between the AP values obtained by the CNAP system and the invasively assessed AP values of 7.9 mm Hg (±9.6 mm Hg, −11.2 to 27.0 mm Hg) for mean AP, 4.8 mm Hg (±15.8 mm Hg, −26.5 to 36.0 mm Hg) for systolic AP, and 9.5 mm Hg (±10.3 mm Hg, −10.9 to 29.9 mm Hg) for diastolic AP, respectively. The concordance rate was 97.5% for mean AP, 95.0% for systolic AP, and 96.7% for diastolic AP, respectively.

CONCLUSIONS:
In the setting of laparoscopic bariatric surgery, continuous noninvasive AP monitoring with the CNAP system showed good trending capabilities compared with continuous invasive AP measurements obtained with a radial arterial catheter. However, absolute CNAP- and arterial catheter–derived AP values were not interchangeable.
Misaligned Feeding May Aggravate Pain by Disruption of Sleep–Awake Rhythm
Authors: Xu Fangxia , Zhao Xin , Liu Huan , Shao Xueming , Chu Shuaishuai , Gong Xiangdan , Ma Zhengliang , Gu Xiaoping 
Published: December 2017

BACKGROUND:
Increasing evidence suggests that patients with eating disorders are more likely to develop chronic pain. A misaligned diet has been reported to disrupt the sleep–awake rhythms. Combined with our previous investigation on circadian pain, we aimed to investigate the role of misaligned diet in the pain sensitivity and the underlying mechanisms.

METHODS:
Two-month-old C57BL/6J male mice were administered chronic constriction injury (CCI) surgery to establish neuropathic pain models. CCI mice were randomized to scheduled food access throughout the whole day (CCI-free), during the daytime (CCI-misaligned), and at night (CCI-aligned), respectively. The paw withdrawal mechanical threshold, indicating pain behavior, was measured by Von Frey. The gross motor activity pattern indicating the sleep–awake rhythm was monitored by Mini-Mitter. Melatonin (Mel) was administered to ameliorate the sleep–awake rhythm (CCI-free + Mel and CCI-misaligned + Mel). The expressions of circadian pain–related proteins were detected by quantitative polymerase chain reaction and western blot. The primary outcome is the pain threshold and the secondary outcome is the sleep–awake rhythm.

RESULTS:
Misaligned diet during the peri-CCI surgery period significantly decreased the paw withdrawal mechanical threshold compared with the CCI-free mice (day 14: 0.40 ± 0.09 vs 0.64 ± 0.15; P = .03;) and altered the sleep–awake rhythm. Mel pretreatment alleviated the increased pain (day 14, CCI-misaligned + Mel versus CCI-misaligned: day 14: 0.60 ± 0.13 vs 0.35 ± 0.12; P = .022) and the disrupted sleep–awake rhythm caused by misaligned feeding. The mRNA levels of N-methyl-d-aspartate receptor subtype 2B (NR2B), Ca2+/calmodulin-dependent protein kinase II (CaMKII), and cyclic adenosine monophosphate-response element binding protein (CREB) in the spinal dorsal horn increased in CCI-misaligned mice compared with the CCI-free mice. The phosphor-NR2B, phosphor-CaMKII, and phosphor-CREB also increased in CCI-misaligned mice compared with the CCI-free mice. However, the expressions of NR2B, CaMKII, and CREB were decreased in CCI-misaligned + Mel mice compared to CCI-misaligned mice at both transcriptional and translational levels.

CONCLUSIONS:
Misaligned diet might aggravate pain sensitivity through the disruption of the sleep–awake cycle, which could be recovered by Mel. NR2B-CaMKII-CREB may participate in the disruption of sleep–awake rhythm–mediated pain aggravation.
The Effect of High-Frequency, Structured Expert Feedback on the Learning Curves of Basic Interventional Ultrasound Skills Applied to Regional Anesthesia
Authors: de Oliveira Filho Getúlio Rodrigues , Mettrau Francisco de Assis Caire 
Published: December 2017

BACKGROUND:
Proficiency in needle-to-ultrasound beam alignment and accurate approach to structures are pivotal for ultrasound-guided regional anesthesia. This study evaluated the effects of high-frequency, structured expert feedback on simulation training of such abilities.

METHODS:
Forty-two subjects randomly allocated as controls or intervention participated in two 25-trial experiments. Experiment 1 consisted of inserting a needle into a bovine muscular phantom parallel to the ultrasound beam while maintaining full imaging of the needle. In experiment 2, the needle aimed to contact a target inside the phantom. Intervention subjects received structured feedback between trials. Controls received a global critique after completing the trials. The slopes of the learning curves derived from the sequences of successes and failures were compared. Change-point analyses identified the start and the end of learning in trial sequences. The number of trials associated with learning, the number of technical errors, and the duration of training sessions were compared between intervention and controls.

RESULTS:
In experiment 1, learning curves departed from 73% (controls) and 76% (intervention) success rates; slopes (standard error) were 0.79% (0.02%) and 0.71% (0.04), respectively, with mean absolute difference of 0.18% (95% confidence interval [CI], 0.17%–0.19%; P = 0). Intervention subjects’ learning curves were shorter and steeper than those of controls. In experiment 2, the learning curves departed from 43% (controls) and 80% (intervention) success rates; slopes (standard error) were 1.06% (0.02%) and 0.42% (0.03%), respectively, with a mean difference of 0.65% (95% CI, 0.64%–0.66%; P = 0). Feedback was associated with a greater number of trials associated with learning in both experiment 1 (mean difference, 1.55 trials; 95% CI, 0.15–3 trials; P = 0) and experiment 2 (mean difference, 4.25 trials; 95% CI, 1.47–7.03 trials; P = 0) and a lower number of technical errors per trial in experiments 1 (mean difference, 0.19; 95% CI, 0.07–0.30; P = .02) and 2 (mean difference, 0.58; 95% CI, 0.45–0.70; P = 0), but longer training sessions in both experiments 1 (mean difference, 9.2 minutes; 95% CI, 4.15–14.24 minutes; P = .01) and 2 (mean difference, 7.4 minutes; 95% CI, 1.17–13.59 minutes; P = .02).

CONCLUSIONS:
High-frequency, structured expert feedback compared favorably to self-directed learning, being associated with shorter learning curves, smaller number of technical errors, and longer duration of in-training improvement, but increased duration of the training sessions.
Accuracy of coronary artery calcium scoring with tube current reduction by 75%, using an adaptive iterative reconstruction algorithm
Authors: Luhur Reny , Schuijf Joanne D , Mews Jürgen , Blobel Jörg , Hamm Bernd , Lembcke Alexander 
Published: December 2017

Objective:
To assess the accuracy of an iterative reconstruction (IR) technique for coronary artery calcium scoring with reduced radiation dose.

Methods:
163 consecutive patients underwent twofold scanning by 320-row detector CT at 120 kVp. A low-dose scan at 25% tube current but with standard scan length (14 cm) was followed by a standard dose scan with routine tube current but reduced scan length (10 cm). Reduced dose images were constructed using filtered back-projection (FBP) and IR (adaptive iterative dose reduction in three dimensions). The standard dose scan reconstructed with FBP served as the gold standard for comparisons. Image noise and Agatston coronary calcium scores were determined and compared between the groups.

Results:
Compared with FBP at standard dose, noise at reduced dose increased markedly with FBP but remained low with IR. Mean Agatston score with FBP at reduced dose showed a significant increase as compared with FBP at standard dose. No significant difference was observed when applying IR at reduced dose. At reduced dose, 38 (23.3%) patients were reassigned to a different cardiovascular risk category with FBP but only 8 (4.9%) with IR. Out of 47 patients with a zero Agatston score, 15 patients (31.9%) were false-positive with FBP at reduced dose, but no false positives were found with IR.

Conclusion:
IR allows accurate coronary artery calcium scoring with a radiation dose reduced by 75%.

Advances in knowledge:
The application of adaptive iterative dose reduction in three dimensions allows the maintenance of accurate Agatston scores and risk stratification at significantly reduced tube current, thus reducing the patient’s exposure to ionizing radiation.
Gender Composition and Group Confidence Judgment: The Perils of All-Male Groups
Authors: Keck Steffen , Tang Wenjie 
Published: December 2017

We explore the joint effects of group decision making and group gender composition on the calibration of confidence judgments. Participants in two laboratory experiments, individually and in groups of three, stated confidence interval estimates for general-knowledge questions and for financial forecasts. Across both studies, our results reveal that groups with at least one female member are significantly better calibrated than all-male groups. This effect is mediated by the extent to which group members share opinions and information during the group discussion. Moreover, we find that compared to a statistical aggregation of individual confidence intervals, group discussions have a neutral or positive effect on the quality of confidence judgments for groups with at least one female group member; in contrast, group discussion actually harms confidence calibration for all-male groups. Overall, our findings indicate that compared to all-male groups, even the inclusion of a small proportion of female members can have a strong effect on the quality of group confidence judgment. Data and the online appendix are available at https://doi.org/10.1287/mnsc.2017.2881 . This paper was accepted by Yuval Rottenstreich, judgment and decision making.
Using a Crop Simulation Model to Understand the Impact of Risk Aversion on Optimal Irrigation Management
Authors: Wibowo Rulianda P. , Hendricks Nathan P. , Kisekka Isaya , Araya Alemie 
Published: December 2017

Abstract. We studied optimal irrigation management by risk-averse farmers with different soil types under limited well capacity. Our modeling framework allowed us to assess the optimal adjustment along the intensive margins (i.e., changes in seasonal irrigation depth) and along the extensive margins (i.e., changes in irrigated area). Our empirical application uses AquaCrop to simulate corn yields with historical weather in southwest Kansas under a large number of potential irrigation strategies. We show that risk aversion significantly increases total water use, especially for low and medium well capacities. While farmers decreased irrigated area due to risk aversion, the increase in water use occurred because it was optimal to increase the seasonal irrigation depth to reduce production risk. The increase in seasonal irrigation depth arises mostly from reduced management allowable depletion (MAD) levels in the initial crop growth stages of corn. Counterintuitively, risk aversion had a smaller impact on water use for a soil with a smaller soil water holding capacity. This result arises because optimal irrigation under risk neutrality is larger for soils with a smaller water holding capacity. Our results highlight the importance of accounting for risk aversion when estimating the optimal irrigation management strategy and show that the impact of risk aversion differs significantly by well capacity and soil type. Keywords: AquaCrop, Irrigation, Risk, Well capacity.
Model-Based Deficit Irrigation of Maize in Kansas
Authors: Linker Raphael , Kisekka Isaya 
Published: December 2017

Abstract. Maize is the dominant irrigated crop in Kansas. In recent years, as a result of declining groundwater levels in the Ogallala aquifer and diminished well capacities, farmers are turning to deficit irrigation strategies. This study demonstrates the potential of model-based optimization for determining adequate soil water depletion levels. CERES-Maize was used as surrogate crop, while the AquaCrop model was used in an optimization procedure that determined the optimal water depletion levels. A multi-objective optimization framework was used to determine several combinations of optimal water depletion levels based on ten years of historical weather, and these combinations were tested using an additional 50 years of historical weather. The results show that, although imperfect modeling and weather fluctuations caused the actual yield to be different from the target yield, the fluctuations around the multi-year averages were not significantly larger when testing the irrigation schedule with the CERES-Maize model than when testing it with the AquaCrop model that had been used to develop the irrigation schedule. Keywords: AquaCrop, Center-pivot irrigation, CERES-Maize, Multi-objective optimization.
Assessing the Impacts of Future Climate Conditions on the Effectiveness of Winter Cover Crops in Reducing Nitrate Loads into the Chesapeake Bay Watersheds Using the SWAT Model
Authors: Lee Sangchul , Sadeghi Ali M. , Yeo In-Young , McCarty Gregory W. , Hively W. Dean 
Published: December 2017

Abstract. Winter cover crops (WCCs) have been widely implemented in the Coastal Plain of the Chesapeake Bay Watershed (CBW) due to their high effectiveness in reducing nitrate loads. However, future climate conditions (FCCs) are expected to exacerbate water quality degradation in the CBW by increasing nitrate loads from agriculture. Accordingly, the question remains whether WCCs are sufficient to mitigate increased nutrient loads caused by FCCs. In this study, we assessed the impacts of FCCs on WCC nitrate reduction efficiency in the Coastal Plain of the CBW using the Soil and Water Assessment Tool (SWAT). Three FCC scenarios (2085-2098) were prepared using general circulation models (GCMs), considering three Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) greenhouse gas emission scenarios. We also developed six representative WCC implementation scenarios based on the most commonly used planting dates and species of WCCs in this region. Simulation results showed that WCC biomass increased by ~58% under FCC scenarios due to climate conditions conducive to WCC growth. Prior to implementing WCCs, annual nitrate loads increased by ~43% under FCC scenarios compared to the baseline scenario (2001-2014). When WCCs were planted, annual nitrate loads were substantially reduced by ~48%, and WCC nitrate reduction efficiency was ~5% higher under FCC scenarios relative to the baseline scenario. The increase in WCC nitrate reduction efficiency varied with FCC scenario and WCC planting method. As CO2 concentrations were higher and winters were warmer under FCC scenarios, WCCs had greater biomass and thus demonstrated higher nitrate reduction efficiency. In response to FCC scenarios, the performance of less effective WCC practices (i.e., barley, wheat, and late planting) under the baseline scenario indicated a ~14% higher increase in nitrate reduction efficiency compared to WCC practices with greater effectiveness under the baseline scenario (i.e., rye and early planting) due to warmer temperatures. The SWAT simulation results indicated that WCCs were effective in mitigating nitrate loads accelerated by FCCs, suggesting the role of WCCs in mitigating nitrate loads will likely be even more important under FCCs. Keywords: Future climate conditions (FCCs), SWAT, Water quality, Winter cover crops (WCCs).
Development of a Laser-Guided, Embedded-Computer-Controlled, Air-Assisted Precision Sprayer
Authors: Shen Yue , Zhu Heping , Liu Hui , Chen Yu , Ozkan Erdal 
Published: December 2017

Abstract. An embedded computer-controlled, laser-guided, air-assisted, variable-rate precision sprayer was developed to automatically adjust spray outputs on both sides of the sprayer to match the presence, size, shape, and foliage density of tree crops in real time. The sprayer was the integration of an embedded computer, a touch screen, a 270° radial-range laser sensor, a travel speed sensor, a unique algorithm, a custom-designed automatic flow rate control unit, and 40 pulse-width-modulated (PWM) nozzles. The accuracy of the sprayer to detect different-sized trees and control the spray outputs of individual nozzles based on tree structures was tested in a commercial nursery. Spray deposition qualities between variable-rate and constant-rate operational modes of the sprayer were also compared. Test results demonstrated the capability of the sprayer to measure different trees accurately and then control the spray outputs of nozzles independently to match tree structure. The outline profile similarity of paired images taken with a digital camera and with the laser sensor for three trees ranged from 0.81 to 0.89. To spray trees of different sizes and shapes, the sprayer in variable-rate mode (VRM) consumed 12.1% to 43.3% of the spray volume that was used in constant-rate mode (CRM) with an application rate of 468 L ha-1. Moreover, the sprayer had 30% and 55% greater coverage areas per amount of spray deposits in VRM than in CRM. This innovative sprayer should have significant potential to reduce pesticide waste, provide sustainable crop protection to growers, and safeguard the environment. Keywords: Automation, Nursery, Orchard, Precision agriculture, Variable-rate sprayer.