bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW
Authors: Adams Clare M. , Mitra Ramkrishna , Gong Jerald Z. , Eischen Christine M. 
Published: August 2017

Abstract
Purpose: B-cell lymphomas must acquire resistance to apoptosis during their development. We recently discovered BCLW, an antiapoptotic BCL2 family member thought only to contribute to spermatogenesis, was overexpressed in diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. To gain insight into the contribution of BCLW to B-cell lymphomas and its potential to confer resistance to BCL2 inhibitors, we investigated the expression of BCLW and the other antiapoptotic BCL2 family members in six different B-cell lymphomas.
Experimental Design: We performed a large-scale gene expression analysis of datasets comprising approximately 2,300 lymphoma patient samples, including non-Hodgkin and Hodgkin lymphomas as well as indolent and aggressive lymphomas. Data were validated experimentally with qRT-PCR and IHC.
Results: We report BCLW is significantly overexpressed in aggressive and indolent lymphomas, including DLBCL, Burkitt, follicular, mantle cell, marginal zone, and Hodgkin lymphomas. Notably, BCLW was preferentially overexpressed over that of BCL2 and negatively correlated with BCL2 in specific lymphomas. Unexpectedly, BCLW was overexpressed as frequently as BCL2 in follicular lymphoma. Evaluation of all five antiapoptotic BCL2 family members in six types of B-cell lymphoma revealed that BCL2, BCLW, and BCLX were consistently overexpressed, whereas MCL1 and A1 were not. In addition, individual lymphomas frequently overexpressed more than one antiapoptotic BCL2 family member.
Conclusions: Our comprehensive analysis indicates B-cell lymphomas commonly select for BCLW overexpression in combination with or instead of other antiapoptotic BCL2 family members. Our results suggest BCLW may be equally as important in lymphomagenesis as BCL2 and that targeting BCLW in lymphomas should be considered. Clin Cancer Res; 23(22); 7119–29. ©2017 AACR.
Optimal Siting and Sizing of Solar Power Sources in Interconnection Grid System
Authors: Reddy S Yogendra , Reddy Daka Seshi , Rao G. Kesava 
Published: August 2017

<span>Growing concerns electrical power demand in need and necessity of daily livelihood of life. Impacted over addition power demanded there is climate impacts, environmental conditions due to conventional power generation resulted in improvement of cheaper solar power generation in the whole distribution system network, and programs offered by governments have contributed to an increment in the number of distributed energy resources (DERs) system in commercial and domestic electrical power output. It is well known that fact the non-optimal size and non-optimal siting system may lead to high power losses, bad voltage profiles and high losses of profit margins of DISCOM’s end. Therefore, this paper to determine the location best siting and filler of multiple DERs generators supported power loss, generation units, and cheaper power transfer demonstrated through IEEE 30 bus standard test system with help of Power World Simulator Package and single line drawing of 2MW solar PV power plant added to APDISCOM </span>
Transient Stability Improvement Using UPFC-SMES in A Multi Machine Power System
Authors: Joshi Kantilal Dayalal , Chandrakar Vinod 
Published: August 2017

Unified Power Flow Controller (UPFC) is a Voltage sourced converter based Flexible A.C.Transmission (FACTS) controller which has a capability of simultaneously or selectively controlling all the parameters affecting transmission of power. With emphasis on harnessing renewable energy many energy storage technologies are being used. Superconducting magnetic energy storage (SMES) stores energy in magnetic form by means of a D.C. current circulating in a superconducting coil. To exchange power with SMES a power electronic interface is required. Feasibility of interfacing SMES to D.C. link of UPFC has been explored in this paper. A multimachine system with a long transmission line is compensated by UPFC-SMES .A DC-DC chopper modulates power of SMES so as to improve the transient stability of system. Complete simulation has been done using MATLAB/Simulink which shows improvement of first peak, damping of oscillations &amp; improvement in critical clearing time.
Shunt-Series FACTS Devices on Network Constrained Unit Commitment
Authors: Hajivar G.A. M. Hosaini , Mortazavi S.S. 
Published: August 2017

<p>Shunt-Series FACTS Devices (SSFD) would play an important role in maintaining security and reduce Total Generation Cost (TGC) in the economical operation of power systems. The application of this devices to the AC model of Network-Constrained Unit Commitment (NCUC) for the day ahead scheduling is presented in this paper. The proposed AC model of NCUC with SSFD would include active and reactive power flow constraints which increase the network controllability at normal operation. A general SSFD model is introduced for the reactive power management in NCUC which is based on the reactive power injection model (RPIM). The case studies reveal that power transfer capability and voltage profile of the power system is improved by compensating SSFD. Meanwhile simulation results demonstrate the combined use of these devices to NCUC have a significant impact on maintaining network security, lower TGC and increase using the maximum capacity of the existing transmission network.</p><p> </p>
A Multi-objective Hybrid Heuristic Approach for Optimal Setting of FACTS Devices in Power System Operation
Authors: Inkollu Sai Ram , Kota Venkata Reddy 
Published: August 2017

<p>Improvement of power system performance in terms of increased voltage profile and decreased transmission loss is becoming one of the challenging tasks to the system operators under open access environment. Apart from traditional power flow controlling devices, use of Flexible AC Transmission System (FACTS) devices can give an attractive solution for the operation and control of deregulated power system. The type, size, location and number of FACTS devices are to be optimized appropriately in order to get the targeted benefits. In this paper, two FACTS devices, Thyristor Controller Phase Shift Transformer (TCPST) and Interline Power Flow Controller (IPFC) are selected to obtain the required performance such as improvement of voltage profile and loss minimization. To search the optimal location and optimal rating of the selected FACTS devices, a hybrid algorithm which formulated with Particle Swarm Optimization (PSO) and Gravitational Search Algorithm (GSA) is proposed. At the first step, the optimization problem is solved for finding the optimal location of FACTS devices using PSO with an objective of voltage profile maximization and later GSA is implemented to optimize their parameters with an objective of transmission loss minimization. The proposed method is implemented on IEEE 30-bus test system and from the simulation results it can be proved that this technique is well suited for real-time application. </p><p align="center"><strong><br /></strong></p>
Modeling, Analysis and Control of Different DC-DC Converter Topologies for Photo Voltaic Emulator
Authors: Iqbal Mohammad Tauquir , Tariq Mohd 
Published: August 2017

This paper presents the modeling, analysis and control of different DC-DC converter topologies to emulate the photovoltaic (PV) system. A PV emulator is basically a DC-DC converter having same electrical characteristics that of solar PV panel. The emulator helps to achieve real characteristics of PV system in a better way in an environment where using actual PV systems can produce inconsistent results due to variation in weather conditions. The paper describes different types of DC-DC converters like buck, Resonant and Quasi Resonant Converter. The complete system is modelled in MATLAB<sup>®</sup> Simulink SimPowerSystem software package. The Simulation results obtained from the MATLAB<sup>®</sup> Simulink SimPowerSystem software package for different topologies under steady and dynamic conditions are analyzed and presented. An evaluation table is also presented at the end of the paper, presenting the effectiveness of each topology.
Preliminary Thoughts on Marine Spatial Planning in Areas beyond National Jurisdiction
Authors: Becker-Weinberg Vasco 
Published: August 2017

Abstract
The conservation and sustainable use of biological diversity in areas beyond national jurisdiction is one of the most controversial issues facing the law of the sea, and one that will probably be the scope of a new implementing agreement of the United Nations Convention on the Law of the Sea (losc). The agreement will address a set of challenges not on the agenda at the time losc was drafted, constituting an opportunity for addressing innovative notions, but also to question established ones as States attempt to ensure the compatibility between the former and the latter. One of the many challenges and a key aspect is the adoption of area-based management tools such as marine spatial planning. This article examines the existing legal gap regarding the conservation and sustainable use of biological diversity in areas beyond national jurisdiction and the use of marine spatial planning as an essential area-based management tool.
Small-Scale Wind Fluctuations in the Tropical Tropopause Layer from Aircraft Measurements: Occurrence, Nature, and Impact on Vertical Mixing
Authors: Podglajen Aurélien , Bui T. Paul , Dean-Day Jonathan M. , Pfister Leonhard , Jensen Eric J. , Alexander M. Joan , Hertzog Albert , Kärcher Bernd , Plougonven Riwal , Randel William J. 
Published: August 2017

Abstract
The contribution of turbulent mixing to heat and tracer transport in the tropical tropopause layer (TTL) is poorly constrained, partly owing to a lack of direct observations. Here, the authors use high-resolution (20 Hz) airborne measurements to study the occurrence and properties of small-scale (&lt;100 m) wind fluctuations in the TTL (14–19 km) over the tropical Pacific. The fluctuations are highly intermittent and appear localized within shallow (100 m) patches. Furthermore, active turbulent events are more frequent at low altitude, near deep convection, and within layers of low gradient Richardson number. A case study emphasizes the link between the turbulent events and the occurrence of inertio-gravity waves having small horizontal or vertical scale. To evaluate the impact of the observed fluctuations on tracer mixing, their characteristics are examined. During active events, they are in broad agreement with inertial-range turbulence theory: the motions are close to 3D isotropic and the spectra follow a −5/3 power-law scaling. The diffusivity induced by turbulent bursts is estimated to be on the order of 10−1 m2 s−1 and increases from the top to the bottom of the TTL (from ~2 × 10−2 to ~3 × 10−1 m2 s−1). Given the uncertainties involved in the estimate, this is in reasonable agreement (about a factor of 3–4 lower) with the parameterized turbulent diffusivity in ERA-Interim, but it disagrees with other observational estimates from radar and radiosondes. The magnitude of the consequent vertical transport depends on the altitude and the tracer; for the species considered, it is generally smaller than that induced by the mean tropical upwelling.
An RCA Analysis of India–China Trade Integration
Authors: Ahmad Imran , Kunroo Mohd Hussain , Sofi Irfan Ahmad 
Published: August 2017

The present study discusses the short- and long-run trade patterns of India and China. Applying revealed comparative advantage (RCA) and bilateral RCA, this study specifically tries to find out the pattern of exports and areas of specialization of the economies under study. Major findings suggest that both the countries have been performing well, in terms of merchandise trade exports, over the past few decades, especially since 2000. The export-performing behaviour of India and China with each other, as well as with the world, is seen quite general in nature. In other words, irrespective of their institutional and structural differences, both India and China maintain almost the same upward moving trend with respect to the flow of exports between them and that with the world market. However, once we go from Standard International Trade Classification (SITC) two-digit to SITC four-digit level of analysis, the sample economies reveal their specialized products. At the disaggregate level, India’s export basket is void of food products and raw materials, and it generally contains engineering goods and technologically driven products as advantageous products. The study finds that the areas of specialization are much wider, and the technology-embedded products are larger for China as compared to India. JEL: F10, F11, F43
Altered thalamic connectivity during spontaneous attacks of migraine without aura: A resting-state fMRI study
Authors: Amin Faisal Mohammad , Hougaard Anders , Magon Stefano , Sprenger Till , Wolfram Frauke , Rostrup Egill , Ashina Messoud 
Published: August 2017

Background Functional connectivity of brain networks may be altered in migraine without aura patients. Functional magnetic resonance imaging (fMRI) studies have demonstrated changed activity in the thalamus, pons and cerebellum in migraineurs. Here, we investigated the thalamic, pontine and cerebellar network connectivity during spontaneous migraine attacks. Methods Seventeen patients with episodic migraine without aura underwent resting-state fMRI scan during and outside of a spontaneous migraine attack. Primary endpoint was a difference in functional connectivity between the attack and the headache-free days. Functional connectivity was assessed in four different networks using seed-based analysis. The chosen seeds were in the thalamus (MNI coordinates x,y,z: right, 22,–24,0 and left, –22,–28,6), pons (right, 8,–24,–32 and left, –8,–24,–32), cerebellum crus I (right, 46,–58,–30 and left, –46,–58,–30) and cerebellum lobule VI (right, 34,–42,–36 and left, –32,–42,–36). Results We found increased functional connectivity between the right thalamus and several contralateral brain regions (superior parietal lobule, insular cortex, primary motor cortex, supplementary motor area and orbitofrontal cortex). There was decreased functional connectivity between the right thalamus and three ipsilateral brain areas (primary somatosensory cortex and premotor cortex). We found no change in functional connectivity in the pontine or the cerebellar networks. Conclusions The study indicates that network connectivity between thalamus and pain modulating as well as pain encoding cortical areas are affected during spontaneous migraine attacks.
Image-Guided Prostate Cryosurgery: State of the Art
Authors: Onik Gary 
Published: August 2017

Background Cryosurgery was first used to treat prostate cancer in the early 1970s but it was not until 1993, when the results from percutaneous ultrasound-guided cryosurgery were published, that the potential advantages of this treatment became apparent. Changes in equipment and techniques have improved the results of cryosurgery, in both tumor control and lower morbidity. Methods The author has reviewed data of his own and those of others concerning the changes in techniques employed and outcomes from prostate cryosurgery. Results Ultrasound-guided percutaneous transperineal placement of the cryoprobes allows monitoring of freezing in real time. Monitoring temperature at critical locations, separating the rectum and prostate by saline injection, and using argon gas rather than liquid nitrogen-based equipment have improved results and lowered complication rates. The technique produces outcomes similar to those obtained with brachytherapy and three-dimensional conformal radiation therapy. Conclusions Advantages of cryosurgery include the ability to re-treat patients without added morbidity and to treat salvage postradiation patients with acceptable results and morbidity. The recent demonstration that “nerve-sparing” cryosurgery is possible suggests that cryosurgery may be used more often.
Acromegaly: A New Therapy
Authors: Friend Keith E. 
Published: August 2017

Background The treatment of acromegaly can be challenging. Despite a multimodality approach (surgery, radiation, dopamine agonists, somatostatin analogs), many patients do not achieve normalization of serum insulin-like growth factor I (IGF-I) concentrations. Methods The author discusses the characteristics and indications of pegvisomant therapy for patients with acromegaly and compares the use of this newly developed GH receptor antagonist with other pharmacological agents such as somatostatin and dopamine agonists. Results Therapy with pegvisomant allows serum IGF-I concentrations to be normalized in up to 97% of patients with acromegaly, including those who have failed other treatment modalities. With this agent, circulating GH levels increase as a result of the drop in IGF-I levels. The rise is rapid (within 2 weeks) and does not appear to be progressive over time. Conclusions Published studies have shown pegvisomant to have efficacy in the treatment of acromegaly. As it appears to be well tolerated and safe, this novel compound may be an important therapeutic option for patients with acromegaly. Additional study of this novel agent and its mode of action is warranted.
Applications of Endoscopic Ultrasonography in Pancreatic Cancer
Authors: Varadarajulu Shyam , Wallace Michael B. 
Published: August 2017

BackgroundAccurate staging of pancreatic cancer is essential for surgical planning and for identification of locally advanced and metastatic disease that is incurable by surgery. Advances in endoscopic sonography (EUS), computed tomography (CT), and positron emission tomography have improved the accuracy of staging and reduced the number of incomplete surgical resections. Tissue acquisition is necessary in nonsurgical cases when chemoradiotherapy is considered. The complex regional anatomy of the pancreas makes cytologic diagnosis of malignancy at this region difficult without exploratory surgery. Although CT-guided fine-needle aspiration (FNA) is used for this purpose, reports of an increased risk of peritoneal dissemination of cancer cells and a false-negative rate of nearly 20% make this a poor choice. The ability to position the EUS-transducer in direct proximity to the pancreas by means of the stomach and duodenum, combined with the use of FNA, increases the specificity of EUS in detecting pancreatic malignancies.MethodsThe current literature regarding the accuracy of EUS with FNA in the evaluation of pancreatic cancer is reviewed.ResultsEUS accuracy ranges from 78% to 94% for tumor staging and from 64% to 82% for nodal staging. EUS also enables FNA of lesions that are too small to be identified by CT or MRI or too well encased by surrounding vascular structures to safely allow percutaneous biopsy. The accuracy for detecting invasion into the superior mesenteric artery and vein is lower than that for detecting portal or splenic vein invasion, especially for large tumors. EUS permits delivery of localized therapy such as celiac plexus neurolysis for pain control and direct intra-lesional injection of antitumor therapy.ConclusionsEUS in combination with FNA is a highly accurate method of preoperative staging of pancreatic cancer, especially those too small to be characterized by CT or MRI, and it has the ability to obtain cytological confirmation of pancreatic cancer.
Targeted Therapy in Multiple Myeloma
Authors: Chng Wee Joo , Lau Lee Gong , Yusof Noorainun , Mow Benjamin M. F. 
Published: August 2017

Background:Multiple myeloma (MM) is an incurable malignancy. Recent insights into its biology has allowed the use of novel therapies targeting not only the deregulated intracellular signaling in MM cells but also its interaction with the bone marrow microenvironment that confers drug resistance, growth, and survival advantage to the malignant cells.Methods:We review and summarize the recent advances in our knowledge of myeloma biology as well as the mechanism of action and clinical efficacy for novel therapeutic agents in clinical trials.Results:Several novel therapeutic agents are currently in clinical trials. Thalidomide is already established for both initial and salvage treatment. Bortezomib is being tested alone and in combination with conventional chemotherapy in various settings. Other agents are less effective in producing response but have been able to stabilize disease in patients with relapsed and/or refractory disease, such as arsenic trioxide, farnesyltransferase inhibitors, 2-methoxyestradiol, and vascular endothelial growth factor receptor inhibitors. Insights into drug resistance mechanism have also led to the development of novel agents that sensitize myeloma cells to chemotherapy (Bcl-2 antisense). Gene expression studies have in many instances identified pathways other than the intended target of the drug and have provided insights into the therapeutic mechanisms.Conclusions:In the future, patients with MM will have more therapeutic options available than ever before. The challenge will be to identify patient subgroups that will benefit most from the different therapies and then determine how these biologically based therapies could be combined and incorporated into the overall management of patients.
Small Molecule and Monoclonal Antibody Therapies in Neurooncology
Authors: Butowski Nicholas , Chang Susan M. 
Published: August 2017

Background: The prognosis for most patients with primary brain tumors remains poor. Recent advances in molecular and cell biology have led to a greater understanding of molecular alterations in brain tumors. These advances are being translated into new therapies that will hopefully improve the prognosis for patients with brain tumors. Methods: We reviewed the literature on small molecule targeted agents and monoclonal antibodies used in brain tumor research and brain tumor clinical trials for the past 20 years. Results: Brain tumors commonly express molecular abnormalities. These alterations can lead to the activation of cell pathways involved in cell proliferation. This knowledge has led to interest in novel anti-brain-tumor therapies targeting key components of these pathways. Many drugs and monoclonal antibodies have been developed that modulate these pathways and are in various stages of testing. Conclusions: The use of targeted therapies against brain tumors promises to improve the prognosis for patients with brain tumors. However, as the molecular pathogenesis of brain tumors has not been linked to a single genetic defect or target, molecular agents may need to be used in combinations or in tandem with cytotoxic agents. Further study of these agents in well-designed cooperative clinical trials is needed.
Novel Agents and Targets in Managing Patients with Metastatic Prostate Cancer
Authors: Tan Winston W. 
Published: August 2017

Background Docetaxel has recently been found to improve survival in patients with metastatic androgen-independent prostate cancer (AIPC). Chemotherapy as a first-line option leaves room for improvement, while second-line options are multiple and somewhat controversial. Methods Clinically relevant articles focusing on chemotherapy drugs for metastatic prostate cancer and their mechanism of action and efficacy were reviewed from January 2004 through April 2006. Results Docetaxel is the standard of care for AIPC. However, for doublets with docetaxel or second-line chemotherapy, multiple studies have shown interesting and promising results with calcitriol, thalidomide, bevacizumab, satraplatin, vaccines, ixabepilone, and atrasentan. Conclusions Docetaxel should be considered for first-line treatment of metastatic AIPC. Due to its progression-free survival of only 6 months, more effective drugs and drug combinations need to be developed to treat patients with AIPC. Combination treatments with docetaxel and other new agents are promising, but adequately powered phase III trials need to be conducted with survival as the principal endpoint for these promising drug combinations.