bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural evolution of the R‐T phase boundary in KNN‐based ceramics
Authors: Lv Xiang , Wu Jiagang , Xiao Dingquan , Zhu Jianguo , Zhang Xixiang 
Published: October 2017

AbstractAlthough a rhombohedral‐tetragonal (R‐T) phase boundary is known to substantially enhance the piezoelectric properties of potassium‐sodium niobate ceramics, the structural evolution of the R‐T phase boundary itself is still unclear. In this work, the structural evolution of R‐T phase boundary from −150°C to 200°C is investigated in (0.99−x)K0.5Na0.5Nb1−ySbyO3–0.01CaSnO3–xBi0.5K0.5HfO3 (where x = 0‐0.05 with y = 0.035, and y = 0‐0.07 with x = 0.03) ceramics. Through temperature‐dependent powder X‐ray diffraction (XRD) patterns and Raman spectra, the structural evolution was determined to be Rhombohedral (R, <−125°C)→Rhombohedral + Orthorhombic (R + O, −125°C to 0°C)→Rhombohedral + Tetragonal (R + T, 0 °C to 150°C)→dominating Tetragonal (T, 200°C to Curie temperature (TC)) → Cubic (C, >TC). In addition, the enhanced electrical properties (e.g., a direct piezoelectric coefficient (d33) of ~450 ± 5 pC/N, a conversion piezoelectric coefficient () of ~580 ± 5 pm/V, an electromechanical coupling factor (kp) of ~0.50 ± 0.02, and TC~250°C), fatigue‐free behavior, and good thermal stability were exhibited by the ceramics possessing the R‐T phase boundary. This work improves understanding of the physical mechanism behind the R‐T phase boundary in KNN‐based ceramics and is an important step toward their adoption in practical applications.
Establishment and evaluation of a peanut association panel and analysis of key nutritional traits
Authors: Zhang Xiurong , Zhu Suqing , Zhang Kun , Wan Yongshan , Liu Fengzhen , Sun Qingfang , Li Yingjie 
Published: October 2017

AbstractBreeding programs aim to improve the yield and quality of peanut (Arachis hypogaea L.); using association mapping to identify genetic markers linked to these quantitative traits could facilitate selection efficiency. A peanut association panel was established consisting of 268 lines with extensive phenotypic and genetic variation, meeting the requirements for association analysis. These lines were grown over 3 years and the key agronomic traits, including protein and oil content were examined. Population structure (Q) analysis showed two subpopulations and clustering analysis was consistent with Q‐based membership assignment and closely related to botanical type. Relative Kinship (K) indicated that most of the panel members have no or weak familial relatedness, with 52.78% of lines showing K = 0. Linkage disequilibrium (LD) analysis showed a high level of LD occurs in the panel. Model comparisons indicated false positives can be effectively controlled by taking Q and K into consideration and more false positives were generated by K than Q. A preliminary association analysis using a Q + K model found markers significantly associated with oil, protein, oleic acid, and linoleic acid, and identified a set of alleles with positive and negative effects. These results show that this panel is suitable for association analysis, providing a resource for marker‐assisted selection for peanut improvement.
Impaired AMPA receptor trafficking by a double knockout of zebrafish olfactomedin1a/b
Authors: Nakaya Naoki , Sultana Afia , Tomarev Stanislav I. 
Published: October 2017

AbstractThe olfm1a and olfm1b genes in zebrafish encode conserved secreted glycoproteins. These genes are preferentially expressed in the brain and retina starting from 16 h post‐fertilization until adulthood. Functions of the Olfm1 gene is still unclear. Here, we produced and analyzed a null zebrafish mutant of both olfm1a and olfm1b genes (olfm1 null). olfm1 null fish were born at a normal Mendelian ratio and showed normal body shape and fertility as well as no visible defects from larval stages to adult. Olfm1 proteins were preferentially localized in the synaptosomes of the adult brain. Olfm1 co‐immunoprecipitated with GluR2 and soluble NSF attachment protein receptor complexes indicating participation of Olfm1 in both pre‐ and post‐synaptic events. Phosphorylation of GluR2 was not changed while palmitoylation of GluR2 was decreased in the brain synaptosomal membrane fraction of olfm1 null compared with wt fish. The levels of GluR2, SNAP25, flotillin1, and VAMP2 were markedly reduced in the synaptic microdomain of olfm1 null brain compared with wt. The internalization of GluR2 in retinal cells and the localization of VAMP2 in brain synaptosome were modified by olfm1 null mutation. This indicates that Olfm1 may regulate receptor trafficking from the intracellular compartments to the synaptic membrane microdomain, partly through the alteration of post‐translational GluR2 modifications such as palmitoylation. Olfm1 may be considered a novel regulator of the composition and function of the α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor complex.
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Skin penetration andUV‐damage prevention by nanoberries
Authors: Bucci Paula , Prieto María Jimena , Milla Laura , Calienni María Natalia , Martinez Luis , Rivarola Viviana , Alonso Silvia , Montanari Jorge 
Published: October 2017

SummaryBackgroundEthanolic extract from blueberry (Vaccinium myrtillus) is rich in anthocyanins and thus exhibits antioxidant activity. On the other hand, ultradeformable liposomes are capable of penetrating to the impermeable barrier of skin. Nanoberries are ultradeformable liposomes carrying blueberry extract.ObjectivesIn this study, their capacity to penetrate thestratum corneumand photodamage prevention were tested, with the aim of developing a topical formulation for skin protection from environmental damage.MethodsNanoberries were prepared by lipid film resuspension with ethanolic extract from blueberry, followed by sonication and incorporation to a gel. Size, zeta potential, deformability, rheology, and viscoelasticity were determined. Toxicity was assessed in vivo in zebrafish model, while in vitro cytotoxicity assay was performed on HaCaT andHEK‐293T cell lines. Skin penetration was evaluated with the Saarbrücken penetration model followed by tape stripping, cryosection, or optical sectioning.UV‐damage protection and photoprotection were determined by ad hoc methods withUVA,UVB, andUVCradiation on HaCaT cells. Wound assay was performed on HaCaT cells.ResultsNanoberries of about 100 nm, with differential elastic properties, did penetrate thestratum corneum, with low toxicity. When HaCaT cells were exposed toUVradiation in the presence of nanoberries, their viability was maintained.ConclusionsNanoberries could be effective to protect the skin from sun photodamage.
Urethral prolapse in prepubertal females: Report of seven cases
Authors: Liu Chang , Lin Ya , Chen Xiangjian , Li Shi , Zhu Hua 
Published: October 2017

AbstractUrethral prolapse is a rare lesion in female children, with a suggested incidence of one in 5000 in China. Most of the cases reported in children have been in girls of African descent. In this report, we present seven cases of Chinese pediatric patients with urethral prolapse. Patient ages ranged from 2 to 8 years. They all presented with a protruding mass in the vaginal opening and bleeding. Diagnosis was confirmed with the combination of clinical manifestation and supplementary examinations. The patients were treated with either conservative therapy (two of the seven patients) or surgical intervention (five of the seven patients). During a 2‐week to 6‐year follow‐up, no case recurred. The literature on urethral prolapse is reviewed.
Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes
Authors: Dundar Betul , Dincgez Cakmak Burcu , Ozgen Gulten , Tasgoz Fatma Nurgul , Guclu Tugberk , Ocakoglu Gokhan 
Published: October 2017

AbstractAimPreterm premature rupture of membranes (PPROM) is not only the most common distinguishable cause of preterm delivery, but is also associated with adverse neonatal outcomes. We determined the platelet indices in PPROM cases and evaluated their relationship to adverse neonatal outcomes.MethodsFifty patients with PPROM and 50 patients who experienced spontaneous preterm labor at < 37 gestational weeks were evaluated. Complete blood counts, birth weights, Apgar scores, presence of sepsis and respiratory distress syndrome (RDS) and neonatal intensive care unit admission were recorded.ResultsPatients with PPROM had increased mean platelet volumes (9.40 vs 10; P = 0.01), plateletcrit (0.19 vs 0.21; P = 0.03) and a higher frequency of neonatal sepsis (18% vs 38%; P = 0.02). Platelet indices in the patient group were compared according to the development of RDS. Plateletcrit values were higher in the RDS positive group (0.23 ± 0.05 vs. 0.21 ± 0.04; P = 0.04). The cut‐off value for plateletcrit was determined as > 0.22, and the probability of RDS increased 5.86 times when plateletcrit values exceeded 0.22 (odds ratio 5.86, 95% confidence interval 1.01–32.01; P = 0.04). A one‐unit increase in platelet distribution width resulted in a 1.33‐fold increase in the risk of RDS (odds ratio 1.33, 95% confidence interval 1.01–1.77; P = 0.04).ConclusionMean platelet volumes and plateletcrit significantly increased and plateletcrit had a predictive value for RDS in PPROM cases. Monitoring plateletcrit may be promising for predicting the development of RDS, one of the most common and serious complications of PPROM rupture.
Denosumab‐related osteonecrosis of the jaw: A retrospective study
Authors: Egloff‐Juras Claire , Gallois Aurélie , Salleron Julia , Massard Vincent , Dolivet Gilles , Guillet Julie , Phulpin Bérengère 
Published: October 2017

BackgroundOsteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab‐related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors.MethodsTo that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded. The P‐value was set at .005.ResultsA total of 141 patients treated at the ICL between January 2010 and December 2015 were included. All patients were treated with XGEVA®. Of the 141 patients included in the study, 10 developed DRONJ. The incidence of DRONJ increases with the duration of follow‐up as follows: 3% at 1 year, 7% at 2 years, and 8% from 30 months on. No risk factor for necrosis could be identified except the realization of prior dental extraction (P = .025).ConclusionOur results raise important questions about the dental management of these patients, in particular, concerning the healing period between dental extractions and the initiation of Denosumab.
Short‐Term Efficacy and Safety of Torasemide and Furosemide in 366 Dogs with Degenerative Mitral Valve Disease: The TEST Study
Authors: Chetboul V. , Pouchelon J.‐L. , Menard J. , Blanc J. , Desquilbet L. , Petit A. , Rougier S. , Lucats L. , Woehrle F. ,   the TEST study investigators
Published: October 2017

BackgroundFurosemide is the only loop diuretic recommended by the ACVIM consensus guidelines for treatment of congestive heart failure (CHF) in dogs related to degenerative mitral valve disease (DMVD). Torasemide is another potent loop diuretic with a longer half‐life and a higher bioavailability.Objectives(1) To demonstrate that torasemide given once a day (q24h) is noninferior to furosemide given twice a day (q12h) for treating dogs with CHF; (2) and to compare the effect of the 2 drugs on the time to reach a composite cardiac endpoint “spontaneous cardiac death, euthanasia due to heart failure or CHF class worsening.”AnimalsA total of 366 dogs with CHF attributable to DMVD.MethodsAnalysis of 2 prospective randomized single‐blinded reference‐controlled trials was performed. Dogs orally received either torasemide q24h (n = 180) or furosemide q12h (n = 186) in addition to standard CHF therapy over 3 months. The primary efficacy criterion was the percentage of dogs with treatment success assessed in each study. The time to reach the composite cardiac endpoint was used as secondary criterion in the overall population.ResultsTorasemide was noninferior to furosemide (Ptorasemide − Pfurosemide = +7%; 95% CI [−8%; +22%] andPtorasemide − Pfurosemide = +1%; 95% CI [−12%; +14%], respectively, in Study 1 and Study 2). Torasemide (median dose = 0.24 mg/kg/d q24h; range = 0.10–0.69 mg/kg/d) was associated with a 2‐fold reduction in the risk of reaching the composite cardiac endpoint (adjusted HR = 0.47; 95% CI = 0.27–0.82;P = 0.0077) as compared with furosemide (median dose = 1.39 mg/kg q12h; range = 0.70–6.30 mg/kg q12h).Conclusions and Clinical ImportanceTorasemide q24h is an effective oral diuretic in dogs with CHF.
The major leaf ferredoxin Fd2 regulates plant innate immunity in Arabidopsis
Authors: Wang Mo , Rui Lu , Yan Haojie , Shi Hua , Zhao Wanying , Lin Jinshan Ella , Zhang Kai , Blakeslee Joshua J. , Mackey David , Tang Dingzhong , Wei Zhongmin , Wang Guo‐Liang 
Published: October 2017

SummaryFerredoxins, the major distributors for electrons to various acceptor systems in plastids, contribute to redox regulation and antioxidant defence in plants. However, their function in plant immunity is not fully understood. In this study, we show that the expression of the major leaf ferredoxin gene Fd2 is suppressed by Pseudomonas syringae pv. tomato (Pst) DC3000 infection, and that knockout of Fd2 (Fd2‐KO) in Arabidopsis increases the plant's susceptibility to both Pst DC3000 and Golovinomyces cichoracearum. On Pst DC3000 infection, the Fd2‐KO mutant accumulates increased levels of jasmonic acid and displays compromised salicylic acid‐related immune responses. Fd2‐KO also shows defects in the accumulation of reactive oxygen species induced by pathogen‐associated molecular pattern‐triggered immunity. However, Fd2‐KO shows enhanced R‐protein‐mediated resistance to Pst DC3000/AvrRpt2 infection, suggesting that Fd2 plays a negative role in effector‐triggered immunity. Furthermore, Fd2 interacts with FIBRILLIN4 (FIB4), a harpin‐binding protein localized in chloroplasts. Interestingly, Fd2, but not FIB4, localizes to stromules that extend from chloroplasts. Taken together, our results demonstrate that Fd2 plays an important role in plant immunity.
Bringing the study of warfare into theories of nationalism
Authors: Hutchinson John 
Published: October 2017

AbstractThis article argues that warfare has been marginalised in theories of nationalism but that in conjunction with nationalism is vital for understanding the rise of nation‐states, the formation of nations and the nature of the international system. It offers a critique of statist approaches, suggests mechanisms through which warfare may sacralise nations and explores different patterns of nation‐state formation as they affect the interstate system. In particular, it emphasises tensions between state and nation‐formation as activated by the fortunes of war and the destabilising effects of waves of imperial dissolution, which are accompanied by patterns of re‐imperialization. It suggests that it is simplistic both to claim that war has led to a transition from empires to nation‐states and that contemporary practices of war‐making have led to a postnational era.
Coagulopathy as a complication of kidney biopsies in paediatric systemic lupus erythematosus patients with antiphospholipid syndrome
Authors: Nagata Hiroko , Sato Mai , Ogura Masao , Yoshikawa Takahisa , Yamamoto Kazuna , Matsumura Sohshi , Kano Yuji , Saida Ken , Sako Mayumi , Kamei Koichi , Yoshioka Takako , Ogata Kentaro , Ito Shuichi , Ishikura Kenji 
Published: October 2017

ABSTRACTChildren with systemic lupus erythematosus (SLE) generally undergo a pretreatment kidney biopsy. However, some of these patients, especially those with antiphospholipid syndrome (APS), may experience serious coagulopathic complications. We report herein two cases of paediatric SLE with APS in which, despite normal blood test results, the disparate coagulopathic complications of haemorrhage and embolism developed following a kidney biopsy. Case 1 was, an 8‐year‐old male in whom, primary APS was initially diagnosed. Fourteen months later SLE was diagnosed. Based on a percutaneous kidney biopsy, International Society of Nephrology and the Renal Pathology Society (ISN/RPS) class III‐A lupus nephritis was histologically diagnosed. On post‐biopsy Day 9, a giant haematoma in the fascia of the left kidney developed and was accompanied by changes in the vital signs. Case 2, a 13‐year‐old male, initially received the diagnosis of SLE with APS and underwent two courses of pulse methylprednisolone therapy. His coagulation abnormalities improved, and a percutaneous needle kidney biopsy was performed, leading to the histological diagnosis of ISN/RPS class III‐A lupus nephritis. Furthermore, thrombotic microangiopathy was also detected in the renal histopathology. On post biopsy Day 6, the patient experienced right leg pain. A contrast CT and lower extremity ultrasonography detected a massive deep vein thrombosis and partial left pulmonary artery thrombosis. A kidney biopsy in children with SLE and APS can cause lethal coagulopathic complications, and the risks to such patients should be weighed carefully before the procedure is performed.
Inflammatory cell distribution in colon mucosa as a new tool for diagnosis of irritable bowel syndrome: A promising pilot study
Authors: Boyer J. , Saint‐Paul M.‐C. , Dadone B. , Patouraux S. , Vivinus M.‐H. , Ouvrier D. , Michiels J.‐F. , Piche T. , Tulic M. K. 
Published: October 2017

AbstractBackgroundCurrently, there are no histological criteria to diagnose irritable bowel syndrome (IBS). Our aims were (i) to examine the distribution of inflammatory cells in the colon of healthy and IBS subjects and (ii) to find histological diagnosis criteria for IBS.MethodsColonic biopsies were taken from four distinct regions of the colon from 20 controls (HC) and 11 patients with IBS (4 with constipation (IBS‐C) and 7 with diarrhea (IBS‐D) and embedded in paraffin. Macrophages, mast cells, eosinophils, and T lymphocytes were immunostained and positive cells counted.Key ResultsIn both HC and IBS patients, global cellularity decreased from the cecum to the rectum (P < .01) which is attributed to reduced number of macrophages (P < .05) and eosinophils (P < .001) but not T cells. Mast cells were reduced in IBS (P < .05) but not in HC, particularly in IBS‐D (P < .05). Results showed higher number of macrophages in the left colon of IBS subjects than HC (P < .05).Conclusion & InferencesHere we report a decreasing gradient of immune cells from the cecum to the rectum of the human colon. Although global cellularity cannot be used to distinguish between IBS and HC, closer analysis of macrophages and mast cells may be useful markers to confirm IBS histologically and to differentiate between IBS‐C and IBS‐D when clinical presentation alternates between constipation and diarrhoea. This pilot study remains to be confirmed with greater number of patients.
The longitudinal association between weight change and health‐related quality of life in adults and children: a systematic review
Authors: Hayes M. , Baxter H. , Müller‐Nordhorn J. , Hohls J. K. , Muckelbauer R. 
Published: October 2017

SummaryThis systematic review examined longitudinal associations between weight change (weight gain and loss) and both physical and mental aspects of health‐related quality of life (HRQOL) compared with stable weight in adults and children of the general population. MEDLINE, EMBASE, PsycINFO and PubMed databases were searched. Longitudinal observational studies measuring HRQOL with six predefined instruments were synthesized according to type of association: weight change and change in HRQOL (change‐on‐change association) and weight change and HRQOL at follow‐up (predictive association). Twenty studies of adults (n = 15) or children (n = 5) were included. Fifteen studies used the SF‐12 or SF‐36. Results of nine studies in adults examining the change‐on‐change association were combined through a tallying of 606 analyses. Weight gain was most often associated with reduced physical, but not mental HRQOL, across all baseline body mass index categories and in both men and women. Weight loss may be associated with improved physical, but not mental HRQOL, among adults with overweight and obesity. Weight gain was more strongly associated with HRQOL than weight loss, implicating a greater need for preventative strategies to tackle obesity. Results in children and for the predictive association generally reflected these findings but require further research.
Muscle fiber diameter assessment in cleft lip using image processing
Authors: Khan MFJ , Little J , Abelli L , Mossey PA , Autelitano L , Nag TC , Rubini M 
Published: October 2017

ObjectiveTo pilot investigation of muscle fiber diameter (MFD) on medial and lateral sides of the cleft in 18 infants with cleft lip with or without cleft palate (CL/P) using image processing.Material and MethodsFormalin‐fixed paraffin‐embedded (FFPE) tissue samples from the medial and lateral sides of the cleft were analyzed forMFDusing an image‐processing program (ImageJ). For within‐case comparison, a paired Student'sttest was performed. For comparisons between classes, an unpairedttest was used.ResultsImage processing enabled rapid measurement ofMFDwith majority of fibers showing diameter between 6 and 11 μm. There was no significant difference in meanMFDbetween the medial and lateral sides, or betweenCLandCLP. However, we found a significant difference on the medial side (p = .032) between males and females.ConclusionThe image processing onFFPEtissues resulted in easy quantification ofMFDwith finding of a smallerMFDon the medial side in males suggesting possible differences in orbicularis oris (OO) muscle between the two sexes inCLthat warrants replication using larger number of cases. Moreover, this finding can aid subclinical phenotyping and potentially in the restoration of the anatomy and function of the upper lip.
Acceptance and commitment therapy for psychosis and trauma: Improvement in psychiatric symptoms, emotion regulation, and treatment compliance following a brief group intervention
Authors: Spidel Alicia , Lecomte Tania , Kealy David , Daigneault Isabelle 
Published: October 2017

ObjectivesAcceptance and Commitment Therapy (ACT) has shown effectiveness for individuals with psychosis and individuals with a history of childhood trauma, but has not been investigated with people with psychosis who also have a history of childhood trauma. This study aims at determining the efficacy of a mindfulness‐based ACT with this clientele in diminishing psychiatric symptoms, trauma‐related symptoms, as well as in improving treatment adherence.Design and MethodsFifty participants meeting our inclusion criteria were recruited and randomized to take part in either 10 sessions of ACT group, or Treatment as Usual (TAU).ResultsUsing RCT it was found that symptom severity, for both overall symptoms (BPRS) and anxiety (GAD), decreased over the course of the treatment, and participants' ability to regulate their emotional reactions (i.e., accept them) increased. The study also found that treatment engagement increased with regards to help‐seeking for those in the ACT group, compared with the TAU controls.ConclusionsAcceptance and Commitment Therapy offered in a group appears a promising treatment for those with psychosis and history of trauma.Practitioner points

To understand the benefits of ACT with those who suffer from psychosis and a history of trauma.

To further the understanding of the effectiveness of ACT.