bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential psychophysiological effects of operant and cognitive behavioural treatments in women with fibromyalgia
Authors: Thieme K. , Turk D.C. , Gracely R.H. , Flor H. 
Published: June 2016

AbstractBackgroundDetermination of psychophysiological effects of operant behavioural (OBT) and cognitive behavioural treatment (CBT) for fibromyalgia patients.MethodsOne hundred and fifteen female patients randomized to OBT (N = 43), CBT (N = 42), or whole‐body infrared heat (IH) (N = 30) were compared before and after group treatment as well as at 6‐ and 12‐month follow‐ups using intent‐to‐treat analysis (12 drop‐outs). Thirty matched pain‐free controls (CON) served as reference group for the initial psychophysiological analysis. Surface electromyogram (EMG), blood pressure, heart rate (HR) and skin conductance levels (SCL) were continuously recorded during adaptation, baseline, social conflict, mental arithmetic and relaxation tasks.ResultsAt baseline, fibromyalgia patients showed higher SCL and HR, lower diastolic blood pressure and EMG in comparison to controls. OBT and CBT compared to IH significantly reduced pain intensity [OBT: effect size (ES) = 1.21 CI: 0.71–1.71, CBT: ES = 1.23, CI: 0.72–1.74]. OBT increased diastolic blood pressure [ES = 1.13, CI: 0.63–1.63 and CBT reduced SCL (ES) = −0.66, CI: −1.14–0.18] 12 months after treatment. Both CBT and OBT significantly increased EMG levels (OBT: ES = 0.97, CI: 0.48–1.46, CBT: ES = 1.17, CI: 0.67–1.68). In contrast, the IH group did not show any significant changes in the psychophysiological parameters.ConclusionIncreased diastolic blood pressure and decreased pain after OBT suggest a reactivation of baroreflex‐mechanisms in fibromyalgia and a normalization of the blood pressure and pain functional relationship. Reduced SCL following CBT may indicate reduced general arousal levels. Increased muscle tension after CBT and OBT suggest a normalization of physical parameters. The reduction in pain seems to be mediated by different psychophysiological processes, providing support for mechanism‐based treatments might be indicated for CBT and OBT.What does this study add?

Differential physiological stress responses followed different psychological interventions.

While OBT influenced blood pressure by restoring blood pressure‐pain interaction, CBT reduced stress‐related sudomotor activity.

These results implicate specific mediating mechanisms in fibromyalgia suggesting a basis for matching based on specific patient psychophysiological features.
Functional interaction between orexin‐1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats
Authors: Esmaeili M.H. , Reisi Z. , Ezzatpanah S. , Haghparast A. 
Published: June 2016

AbstractBackgroundChemical stimulation of the lateral hypothalamus (LH) with carbachol induces antinociception which is antagonized by blockade of orexin receptors in some pain modulatory sites in the tail‐flick test. In this study, we evaluated the role of orexin‐1 and CB1 receptors in the periaqueductal gray matter (PAG), a critical pain modulatory site, in mediation of antinociceptive responses induced by LH stimulation in rats.MethodsOne hundred thirty‐two adult male albino Wistar rats weighing 180–250 g were unilaterally implanted with two separate cannulae into the LH and ventrolateral PAG (vlPAG). Intra‐vlPAG administration of SB334867, as a selective orexin‐1 receptor antagonist (0.5, 1.5, 5, 15 and 50 nM), or AM251, as a selective CB1 receptor antagonist (1, 3, 10, 30 and 100 nM), was performed just 5 min before carbachol (125 nM) microinjection into the LH.ResultsOur findings showed that SB334867 or AM251 administration dose dependently prevented the development of LH‐induced antinociception in rats. Treatment with two antagonists at the same time could not intensify their effects in comparison with separate administration of antagonists.ConclusionIt seems that antinociceptive effect of intra‐LH administration of carbachol is mediated, at least partially, through the activation of orexin‐1 and CB1 receptors in the vlPAG.SignificanceThis work demonstrates a pain modulatory role of the orexinergic system via the PAG in hypothalamic‐mediated analgesia suggesting that orexins can be advantageously targeted to achieve analgesia.What does this study add?OX1 receptor antagonist (SB334867) administration into the ventrolateral periaqueductal gray matter (vlPAG) dose dependently blocked the carbachol‐induced antinociception. CB1 receptor antagonist (AM251) microinjection in the vlPAG prevented carbachol‐induced antinociception in a dose‐dependent manner. Concurrent administration of SB334867 and AM251 into the vlPAG did not reinforce the antinociceptive responses.
Cleavage of SNAP‐25 ameliorates cancer pain in a mouse model of melanoma
Authors: Olbrich K. , Costard L. , Möser C.V. , Syhr K.M.J. , King‐Himmelreich T.S. , Wolters M.C. , Schmidtko A. , Geisslinger G. , Niederberger E. 
Published: June 2016

AbstractBackgroundCancer pain is associated with increased pain sensitivity to noxious (hyperalgesia) and normally innocuous (allodynia) stimuli due to activation of nociceptors by tumour‐derived mediators or tumour infiltration of nerves. The pain sensitization is accompanied by modifications in gene expression, but specifically regulated genes are largely unknown. The 25 kDa synaptosomal‐associated protein (SNAP‐25) is involved in chemical neurotransmission at the synaptic cleft. Its inhibition by Botulinum neurotoxin A (BoNT/A) has been associated with antinociceptive effects in migraine, inflammatory and neuropathic pain. However, its potential to reduce tumour‐associated pain remains to be clarified.MethodsWe applied a melanoma model of tumour pain in C57BL/6 mice and investigatedSNAP‐25 expression and regulation byqRT‐PCR, Western Blot and immunofluorescence as well as tumour‐associated mechanical allodynia with and without BoNT/A treatment.ResultsWe found increasedSNAP‐25 expression in the dorsal root ganglia and the sciatic nerve. Intraplantar injection of BoNT/A induced the cleavage ofSNAP‐25 in these tissues and was associated with decreased mechanical allodynia after therapeutic treatment at early and late stages of tumour pain while the tumour size was not affected.ConclusionsOur data indicate thatSNAP‐25 plays a role in tumour pain but has no influence on the initiation and progression of skin cancer. Its cleavage inhibits the development of allodynia in the mouse melanoma model and might be useful as new therapeutic approach for the treatment of cancer pain.What does this study add?SNAP‐25 is differentially regulated during melanoma‐induced tumour pain. Its cleavage by BoNT/A might be a suitable therapeutic option for tumour pain patients since tumour‐associated pain can be strongly and significantly reduced after preventive and therapeutic BoNT/A treatment, respectively.
Determination of Local Anesthetics of Amide Group in Pharmaceutical Preparations by Cyclic Voltammetry
Authors: Plotycya Serhij , Dubenska Liliya , Blazheyevskiy Mykola , Pysarevska Solomiya , Sarahman Olha 
Published: June 2016

AbstractA novel voltammetric method of local anesthetics such as lidocaine, trimecaine and mepivacaine determination has been developed. The proposed method was based on the obtaining of anesthetic N‐oxides in oxidation reaction with futher reduction of reaction product. Experimental conditions affecting quantitative yield of anesthetic N‐oxides such as oxidation time, oxidant concentration and temperature were studied. This assay was found to be linear (R=0.999) over a concentration range n⋅10−6–5 ⋅ 10−5 mol L−1. Calculated LOD and LOQ were found to be 0.38 and 1.14 μg mL−1 respectively. Sensitivity of presented method is comparable with that of chromatographic method. Overall, the developed method exhibited good selectivity towards components of pharmaceuticals and biological fluids. The proposed method was successfully applied to the analysis of studied anesthetics in different pharmaceutical samples.
Carbon Aerogel as Electrode Material for Improved Direct Electron Transfer in Biosensors Incorporating Cellobiose Dehydrogenase
Authors: Fort Carmen Ioana , Ortiz Roberto , Cotet Liviu Cosmin , Danciu Virginia , Popescu Ionel Catalin , Gorton Lo 
Published: June 2016

AbstractHigh mesoporous carbon aerogels (CA) were prepared by a sol‐gel method, followed by supercritical drying with liquid CO2and pyrolysis under inert atmosphere. The morphological and structural characteristics (surface area, pore size distribution and pore volume) of CA were examined by using N2adsorption/desorption isotherms, TEM, SEM and AFM measurements. CA, dispersed in a chitosan (Chi) solution, was immobilized on the surface of a glassy carbon (GC) electrode aiming to prepare an amperometric transducer able to improve the direct electron transfer (DET) betweenPhanerochaete chrysosporiumcellobiose dehydrogenase (PcCDH) and the electrode. The resulting GC/CA‐Chi/PcCDH biosensor was optimized with regards to the loading of CA andPcCDH, as well as pH of the buffer solution. The electroanalytical parameters of the optimized biosensor (maximum current responses (Imax), apparent Michaelis‐Menten constants (KM)) were estimated from amperometric calibration curves for lactose. The remarkably high sensitivity towards lactose (133.7±0.2 µA cm−2 mM−1) at the GC/CA‐Chi/PcCDH electrode recommends the GC/CA‐Chi electrode as an efficient transducer forPcCDH based biosensors, exploiting DET.
Evaluation of a passive gap damper to control displacements in a shaking test of a seismically isolated three‐story frame
Authors: Zargar Hamed , Ryan Keri L. , Rawlinson Taylor A. , Marshall Justin D. 
Published: June 2016

SummaryRecent studies have indicated uncertainty about the performance limit states of seismically isolated buildings in very large earthquakes, especially if the isolator displacement demands exceed the seismic gap and induce pounding. Previous research has shown the benefit of providing phased supplemental damping that does not affect the isolation system response in a design event. A phased passive control device, or gap damper, was designed, fabricated, and experimentally evaluated during shake table testing of a quarter scale base‐isolated three‐story steel frame building. Identical input motions were applied to system configurations without a gap damper and with a gap damper, to directly assess the influence of the gap damper on displacement and acceleration demands. The gap damper was observed to reduce displacement demands by up to 15% relative to the isolated system without the gap damper. Superstructure floor accelerations increased substantially because of damper activation, but were limited to a peak of about 1.18 g. The gap damper reduces displacement most effectively if the ground motion contains one or more of the following characteristics: the spectral displacement increases with increasing period near the effective period of the isolation system, the motion is dominated by a single large pulse rather than multiple cycles at a consistent intensity, and the motion has a dominant component aligned with a major axis of the structure. Copyright © 2016 John Wiley & Sons, Ltd.
Assessing Intercultural Competence in Higher Education: Existing Research and Future Directions
Authors: Griffith Richard L. , Wolfeld Leah , Armon Brigitte K. , Rios Joseph , Liu Ou Lydia 
Published: June 2016

AbstractThe modern wave of globalization has created a demand for increased intercultural competence (ICC) in college graduates who will soon enter the 21st‐century workforce. Despite the wide attention to the concepts and assessment of ICC, few assessments meet the standards for a next‐generation assessment in areas of construct clarity, innovative item types, response processes, and validity evidence. The objectives of this report are to identify current conceptualizations of ICC, review existing assessments and their validity evidence, propose a new framework for a next‐generation ICC assessment, and discuss key assessment considerations. To summarize, we found the current state of the literature to be murky in terms of the clarity of the ICC construct. Definitions of the construct vary considerably as to whether it is a trait, skill, or performance outcome. In addition, current measurements of ICC overly rely on self‐report methods, which have a number of flaws that result in less than optimal assessment. In this paper, we propose a new framework based on a model of the social thinking process developed by Grossman and colleagues that describes the knowledge, skills, and abilities that promote success in complex social situations. From this social process model, as well as Earley and Peterson's definition of ICC (a person's capability to gather, interpret, and act upon these radically different cues to function effectively across cultural settings or in a multicultural situation), three stages are developed: approach, analyze, and act. Guided by this framework, we discuss assessment considerations such as innovative task types and multiple response formats to help translate the framework to an assessment of ICC.
Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential
Authors: Nestmann Earle R. 
Published: June 2016

AbstractPalmitoylethanolamide (PEA) is a natural fatty acid amide found in a variety of foods, which was initially identified in egg yolk. MicroPEA of defined particle size (0.5–10 μm) was evaluated for mutagenicity in Salmonella typhimurium, for clastogenicity/aneuploidy in cultured human lymphocytes, and for acute and subchronic rodent toxicity in the rat, following standard OECD test protocols, in accordance with Good Laboratory Practice (GLP). PEA did not induce mutations in the bacterial assay using strains TA1535, TA97a, TA98, TA100, and TA102, with or without metabolic activation, in either the plate incorporation or liquid preincubation methods. Similarly, PEA did not induce genotoxic effects in human cells treated for 3 or 24 h without metabolic activation, or for 3 h with metabolic activation. PEA was found to have an LD50 greater than the limit dose of 2000 mg/kg body weight (bw), using the OECD Acute Oral Up and Down Procedure. Doses for the 90‐day rat oral toxicity study were based on results from the preliminary 14‐day study, that is, 250, 500, and 1000 mg/kg bw/day. The No Effect Level (NOEL) in both subchronic studies was the highest dose tested.
Backfill of segmental lining – State of the art, redistribution behaviour of pea gravel, possible improvements / Tübbingbettung – Stand der Technik, Umlagerungsverhalten von Perlkies, Verbesserungspotenzial
Authors: Henzinger Michael R. , Radončić Nedim , Moritz Bernd A. , Schubert Wulf 
Published: June 2016

AbstractWith mechanized shield tunnelling the quality of the backfill is of significant importance for the stability of the lining. The used material affects the interaction between support and rock mass. Therefore, the choice of a proper backfilling material is of great importance for the system behaviour. Scaled model tests have been carried out investigating the relocation behaviour of pea gravel within the annular gap. The tests have shown that especially with Double shielded TBMs a distinct relocation mechanism is triggered by the regripping process. This leads to an unfavourable bedding situation immediately behind the TBM shield.Within a numerical study the influence of an incomplete bedding situation on the section forces within the lining segments has been carried out. The simulations have shown that crack propagation is more likely in unfavourable bedding situations. Nevertheless, numerical simulations have proven that cracks within the segments denote a higher utilization level but do not directly imply an acute danger to the load‐bearing capacity. As observed in reality, the state of incomplete bedding represents the relevant load case.A design improvement has been introduced overcoming the temporary state of a partially bedded segmental lining. Furthermore, this approach prevents a large‐scale relocation process of pea gravel within the annular gap.Bei Schildvortrieben hat die Qualität der Ringspaltverfüllung einen wesentlichen Einfluss auf die Qualität des Tübbingausbaus. Das verwendete Bettungsmaterial beeinflusst die Interaktion Gebirge‐Tübbingausbau. Deshalb ist die Wahl eines geeigneten Materials für die Ringraumverfüllung von hoher Bedeutung für das Systemverhalten. Zur Untersuchung des Umlagerungsverhaltens von Perlkies innerhalb des Ringspalts wurden Laborversuche durchgeführt. Die Versuche zeigten, dass vor allem bei Doppelschildmaschinen eine ausgeprägte Tendenz zur Umlagerung des Perlkieses in Längsrichtung während des Umsetzvorgangs gegeben ist. In Folge dessen sind die Tübbingringe unmittelbar hinter dem Schildschwanz nur teilgebettet.Mittels numerischer Simulationen wurde der Einfluss der unvollständigen Bettung auf die Schnittkräfte der Tübbingsegmente untersucht. Die Simulationen haben gezeigt, dass die Rissentwicklung vor allem bei ungünstigen Bettungsszenarien bevorzugt auftritt. Weiters wurde festgestellt, dass Betonrisse lediglich auf einen erhöhten Ausnutzungsgrad innerhalb der Stahlbetonfertigteile, jedoch nicht auf eine Gefährdung der Ausbautragfähigkeit hinweisen. Wie in der Realität beobachtet, repräsentiert der Zustand der unvollständigen Bettung den maßgebenden Lastfall.Abschließend wird eine Maßnahme vorgestellt, die die temporäre Bettung gezielt verbessern soll. Zudem verhindert diese eine großräumige Umlagerung von Perlkies innerhalb des Ringspalts.
3D images for digital tunnel face documentation at TBM headings – Application at Koralmtunnel lot KAT2 / 3D‐Bilder zur digitalen Ortsbrustdokumentation bei TBM‐ Vortrieben – Anwendung beim Koralmtunnel Baulos KAT2
Authors: Gaich Andreas , Pötsch Markus 
Published: June 2016

AbstractWithin the scope of a research activity of ÖBB‐Infrastruktur AG (Austrian Federal Railways) improvements for tunnel face documentation during TBM tunnelling are investigated. This contribution presents an autonomous imaging unit for taking videos of the tunnel face. The unit is installed during maintenance shift in the cutter head of a hard rock TBM. While turning the cutter head, a video is taken. Simultaneously a smartphone that also controls the camera tracks the orientation of the imaging system. From the video a consistent three‐dimensional image is generated using latest algorithms from photogrammetry. The resulting 3D images are used for determining single block detachments from the tunnel face as well as quantifying the planarity in general. They serve for enhancing geological mapping including the determination of discontinuities and provide comprehensive and objective documentation information. First successful applications at Koralmtunnel lot KAT2 showed the value of this new way of documentation and measurements.Im Rahmen einer Forschungsaktivität der ÖBB Infrastruktur AG werden Verbesserungen zur Dokumentation der Ortsbrust bei TBM‐Vortrieben untersucht. Dieser Beitrag zeigt eine autonome Aufnahmeeinheit, die Videos der Ortsbrust erfasst. Die Aufnahmeeinheit wird während der Wartungsschicht im Bohrkopf einer Hartgesteins‐Tunnelvortriebsmaschine installiert, und während einer Drehung des Bohrkopfs wird ein Video aufgenommen. Gleichzeitig zeichnet ein Smartphone, das auch die Kamera steuert, Orientierungsinformationen auf. Aus dem Video wird unter Anwendung aktueller Algorithmen der Photogrammetrie ein konsistentes dreidimensionales Bild erzeugt. Die resultierenden 3D‐Bilder werden dazu benutzt, um einzelne Ausbrüche aus der Ortsbrust sowie die Ebenheit der aufgenommenen Bereiche zu quantifizieren. Sie dienen außerdem für eine verbesserte geologische Kartierung inklusive der Bestimmung von Trennflächenorientierungen und stellen eine umfassende und objektive Dokumentation dar. Erste erfolgreiche Anwendungen beim Baulos KAT2 des Koralmtunnels zeigen den Wert dieser neuartigen Art der Dokumentation und messtechnischen Bewertung.
Increased fibrinogen levels at diagnosis are associated with adverse outcome in patients with acute myeloid leukemia
Authors: Berger Martin D. , Heini Alexander D. , Seipel Katja , Mueller Beatrice , Angelillo‐Scherrer Anne , Pabst Thomas 
Published: June 2016

AbstractIncreased plasma fibrinogen levels are associated with shortened overall survival (OS) in some solid tumor types. In contrast, the prognostic significance of varying fibrinogen levels in acute myeloid leukemia (AML) at diagnosis is unknown. In this study, we assessed the prognostic significance of fibrinogen levels in AML patients. In a comprehensive retrospective single‐center study, we determined the survival rates of 375 consecutive AML patients undergoing at least one cycle of intensive chemotherapy induction treatment. Patients were dichotomized between low (<4.1 g/L) and high fibrinogen levels (≥4.1 g/L) at diagnosis of AML before initiation of treatment. Subsequently, quartile ranges were applied to analyze the association of varying fibrinogen levels on survival. We observed that the rates of complete remission, early death, and admission to intensive care unit were equal in the low versus high fibrinogen group. However, OS was significantly better in the low fibrinogen group (27.3 vs 13.5 months; p = 0.0009) as well as progression‐free survival (12.3 vs 7.8 months; p = 0.0076). This survival difference remained significant in the multivariate analysis (p = 0.003). Assessing quartiles of fibrinogen values, we further confirmed this observation. Our data suggest that high fibrinogen levels at diagnosis of AML are associated with unfavorable OS and progression‐free survival but not with increased mortality during induction treatment. Copyright © 2016 John Wiley & Sons, Ltd.
Seeking a Balance: Discussion Strategies That Foster Reading With Authorial Empathy
Authors: Brett Aidan T. 
Published: June 2016

AbstractThis study investigates the extent to which students' use of different discussion strategies fosters a balance between attending to the technical elements of authored texts and responding empathetically. Because small‐group discussion is a common approach to literary study, the analysis focuses on two small‐group discussions of “Charlie Howard's Descent,” Mark Doty's poem about the murder of a young gay man by other young men in his community. The two discussions were parsed into episodes that were scored according to the extent that they displayed balance. Then, each student turn was analyzed in terms of the discussion strategies employed. The analysis suggests that the strategies of searching for meaning, contextualizing, and interpreting contribute to the most balanced readings. Noting author's craft can lead to overly technical readings, although it has the potential to be paired with other strategies to facilitate a more balanced discussion.
At the Intersection of Creativity and Civic Engagement: Adolescents' Literacies in Action
Authors: Bean Thomas W. , Dunkerly‐Bean Judith 
Published: June 2016

AbstractThe purpose of this commentary is to explore the intersection of creativity, civic engagement, and literacy instruction that takes into consideration real‐world concerns. The authors define and consider recent work on creativity and utilize Westheimer's model of citizenship to frame an example of adolescents engaged in both purposeful literacies and civic engagement in a project in which the authors are currently involved. They advocate for providing students with the opportunity to investigate global issues that matter to them while engaging in literacies to address those issues.
Constructions for Circulant and Group‐Developed Generalized Weighing Matrices
Authors: Craigen Robert , de Launey Warwick 
Published: June 2016

AbstractAn elementary construction yields a new class of circulant (so‐called “Butson‐type”) generalized weighing matrices, which have order and weight n2, all of whose entries are nth roots of unity, for all positive integers , where . The idea is extended to a wider class of constructions giving various group‐developed generalized weighing matrices.