bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arteriovenous fistula maturation in patients with permanent access created prior to or after hemodialysis initiation
Authors: Duque Juan C. , Martinez Laisel , Tabbara Marwan , Dvorquez Denise , Mehandru Sushil K. , Asif Arif , Vazquez-Padron Roberto I. , Salman Loay H. 
Published: February 2017

Introduction Multiple factors and comorbidities have been implicated in the ability of arteriovenous fistulas (AVF) to mature, including vessel anatomy, advanced age, and the presence of coronary artery disease or peripheral vascular disease. However, little is known about the role of uremia on AVF primary failure. In this study, we attempt to evaluate the effect of uremia on AVF maturation by comparing AVF outcomes between pre-dialysis chronic kidney disease (CKD) stage five patients and those who had their AVF created after hemodialysis (HD) initiation. Methods We included 612 patients who underwent AVF creation between 2003 and 2015 at the University of Miami Hospital and Jackson Memorial Hospital. Effects of uremia on primary failure were evaluated using univariate statistical comparisons and multivariate logistic regression analyses. Results Primary failure occurred in 28.1% and 26.3% of patients with an AVF created prior to or after HD initiation, respectively (p = 0.73). The time of HD initiation was not associated with AVF maturation in multivariate logistic regression analysis (p = 0.57). In addition, pre-operative blood urea nitrogen (p = 0.78), estimated glomerular filtration rate (p = 0.66), and serum creatinine levels (p = 0.14) were not associated with AVF primary failure in pre-dialysis patients. Conclusions Our results show that clearance of uremia with regular HD treatments prior to AVF creation does not improve the frequency of vascular access maturation.
A comparison of efficacy of endovascular versus surgical repair for the treatment of arteriovenous fistula stenosis in Taiwan
Authors: Fan Szu-Shan , Chen Chien-Wen , Lu Kuo-Cheng , Mao Hung-Chung , Chen Miao-Pei , Chou Chu-Lin 
Published: February 2017

Background Percutaneous transluminal angioplasty (PTA) and fistula reconstruction surgery are therapeutic options for vascular access occlusion in hemodialysis patients. However, owing to its convenience, PTA has gradually become the preferred therapeutic option for fistula stenosis or occlusion. This study investigated the effects of the two therapeutic methods on the vascular access maintenance duration (number of days) and maintenance costs of fistula in dialysis patients from different dialysis units. Methodology In this study, 544 hemodialysis patients from 2 dialysis units in a teaching hospital in the southern area of Taiwan were included in the analysis of the frequency of PTA or revascularization surgery and the use of related medical resources by conducting a retrospective chart review. Results The frequency of PTA in the patients undergoing long-term hemodialysis was not significantly associated with their demographic characteristics. The efficacy of PTA has declined with shorter maintenance duration with increasing PTA frequency. The cost profile of PTA was more expensive than that of fistula revascularization surgery. Conclusions In this study, PTA was found to be just a temporary solution for fistula thrombosis, whereas fistula reconstruction surgery is inexpensive and improves survival time. Therefore, dialysis units should establish an appropriate standard of care to avoid over-reliance on PTA in order to reduce the fistula failure rate, improve the dialysis efficacy, and reduce the psychological stress in patients, as well as to reduce the maintenance costs and rationalize the medical expenses.
Clinical Significance of Circulating Tumor Cells in Patients with Small-cell Lung Cancer
Authors: Wang Yu-Li , Liu Chun-Hua , Li Jing , Ma Xiao-Ping , Gong Ping 
Published: February 2017

Background This study investigated the correlation of the presence of circulating tumor cells (CTCs) with clinical characteristics, and the predictive value of CTCs for progression-free survival (PFS) in patients with small-cell lung cancer (SCLC). Methods Samples were obtained from 42 patients with SCLC before and after the first cycle of chemotherapy. CTCs were quantitated by negative immunomagnetic enrichment and immunocytochemistry using anti-CD45 and anti-pancytokeratin antibodies. Results CTCs were positive (≥2) in 76.19% of patients with SCLC and negative in the control group. The presence of CTCs was positively correlated with 6 clinical characteristics. PFS was 6.055 and 10.670 months for patients with ≥2 and <2 CTCs/7.5 mL of blood before chemotherapy; after chemotherapy PFS was 4.862 and 10.535 months, respectively. Conclusions This study showed that both baseline CTC numbers and the change in CTC numbers after 1 cycle of chemotherapy are significant prognostic factors of PFS for SCLC.
Stereotactic Ablative Radiation Therapy as a Potential Curative Treatment in Duodenal Adenocarcinoma: A Case Report
Authors: Aquilanti Francesco Maria , Barba Maria Cristina , Bianciardi Federico , Tolu Barbara , Nardiello Barbara , Raza Giorgio Hamid , El Gawhary Randa , D'Ambrosio Chiara , Gentile PierCarlo 
Published: February 2017

Purpose One of the rarest gastrointestinal neoplasm is small bowel cancer. Experience with its treatment modalities is limited. Stereotactic ablative radiation therapy (SABR) has improved, with image-guided radiation therapy becoming a curative option in many tumors. Especially when surgery cannot be performed due to comorbidities, SABR provides a good toxicity profile and an excellent tumor control rate owing to its specific schedule: high dose on a limited and well-defined area. Methods An 83-year-old man had arterial hypertension and congestive cardiomyopathy, with recent history of upper abdominal pain, weight loss over 10 kg, and progressive severe fatigue. The patient underwent endoscopy that showed a large mass partially obstructing the second part of the duodenum; a biopsy revealed a moderately differentiated adenocarcinoma. A staging CT scan confirmed localized disease. Due to the patient's age and comorbidities, a SABR was proposed as the preferred treatment. In order to localize the tumor during radiotherapy sessions, surgical clips were placed endoscopically next to the lesion as fiducial markers. The patient received 25 Gy in 5 fractions on alternate days. Results Resolution of duodenal obstruction and bleeding lasted for 14 months. The patient died of myocardial infarction. Conclusions This case suggests that SABR could have a role in the palliative treatment of small bowel cancers, with good toxicity profile, particularly in patients for whom surgical treatment is not a viable option.
La conciliation travail-famille : l’organisation policière canadienne en transformation?
Authors: Diotte Michèle 
Published: February 2017

La féminisation des corps policiers canadiens a transformé certains éléments de la culture organisationnelle et oblige à repenser la conciliation travail-famille dans ce milieu. Les rapports sur les questions d’égalité homme-femme et de diversité au sein de la police se sont multipliés au cours des dernières années et laissent entrevoir la transformation d’un modèle traditionnellement masculin en un modèle plus inclusif. Le regard féministe invite à remettre en question ce propos, car entre discours et « pratique » il y a souvent un écart. L’auteure met donc en lumière l’état des mesures qui existent actuellement dans les grands corps policiers du pays relativement à la conciliation travail-famille et s’interroge sur la matrice dans laquelle s’articule la réflexion sur ce sujet.
Application of Modern Information Systems for More Efficient Removal of Parking Violators
Authors: Dobrić Mladen , Miličić Milica , Gladović Pavle , Dobrić Filip 
Published: February 2017

PUC „Parking servis“ Novi Sad, which has parking spaces organization and exploitation as its narrower activity, in its structure has the Transportation Office whose main task is the removal of parking violators by the order of a competent authority. In this paper Transportation Service’s work organization, transport organization and potential upgrades in business conduct via modern information technologies, will, above all, be considered, as well as the roll of the Transportation Service inside the system of PUC „Parking servis“, and it’s contribution to the Company, from a financial aspect. Described income and cost data are based on the company’s data of business conduct in 2013. Three main measure suggestions will be considered, all based on advanced use of information technologies, implementation of a dispatching unit, and suitable patrol unit - Vehicle of Observatory Purpose (VOP) - maximum, minimum, and real, type of advanced business management.
Detailed study of the Mare Crisium northern magnetic anomaly
Authors: Baek Seul‐Min , Kim Khan‐Hyuk , Garrick‐Bethell Ian , Jin Ho , Lee Hyo‐Jeong , Lee Jung‐Kyu 
Published: February 2017

AbstractLow‐altitude Lunar Prospector (LP) magnetometer data for Mare Crisium show two magnetic anomalies near its inner northern and southern edges. Because these features are located inside a basin, they were likely formed by slow cooling of the basin's melt, or the partially melted mantle, instead of by any impact‐related shock magnetization process. Therefore, they are important for assessing the nature of the ancient dynamo field that produced them. In this study we confine our attention to the simpler northern anomaly (CNA) and use low‐altitude (∼22 km) LP data to model its source body as a dipole and magnetized disks of different radii. We infer that the source is likely located ∼20–30 km from the surface and horizontally localized within a small region (<1° or <∼30 km radius). The surface field intensity calculated from the best fit dipole is in good agreement with that obtained from LP Electron Reflectometer data. Our magnetization directions are substantially different from two previous studies, largely due to using lower altitude data to perform our inversions. We also find a surprising sensitivity to small changes in source body latitude (∼1°). The magnetic paleopoles implied by our best fit models are distant from previous estimates by up to ∼50° of great circle arc and are substantially distant from the Moon's present rotation axis. Our results demonstrate how multiple altitude data sets must be used when estimating paleopoles and other properties of even the simplest of the Moon's magnetic anomalies.
Efficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphoma
Authors: Bennani N. Nora , LaPlant Betsy R. , Ansell Stephen M. , Habermann Thomas. M. , Inwards David J. , Micallef Ivana N. , Johnston Patrick B. , Porrata Luis F. , Colgan Joseph P. , Markovic Svetomir N. , Nowakowski Grzegorz S. , Macon William R. , Reeder Craig B. , Mikhael Joseph R. , Northfelt Donald W. , Ghobrial Irene M. , Witzig Thomas E. 
Published: February 2017

AbstractRelapsed indolent lymphoma often becomes refractory to standard chemoimmunotherapy and requires new therapeutic strategies. Targeting the PI3K/mTOR pathway in several types of lymphoma has shown preclinical and clinical efficacy providing the rationale to test this strategy in the treatment of relapsed/refractory indolent lymphomas. We investigated in a phase II open label clinical trial the efficacy and safety of single agent everolimus, an inhibitor of mTORC1, in patients with relapsed/refractory indolent lymphomas. Eligible patients received oral everolimus 10 mg daily on a 28 day‐cycle schedule. The primary endpoint was to evaluate the overall response rate (ORR) and safety of single‐agent everolimus in this patient population. Fifty‐five patients with indolent lymphoma were accrued. The median age was 67 years (range: 33‐85) with a median of five prior therapies (range: 1‐10). The ORR was 35% (19/55; 95% CI: 24‐48%), with complete response unconfirmed in 4% (2/55), and partial response in 31% (17/55). The ORR was 61% (14/23) in the patients with FL. The median time to response was 2.3 months (range: 1.4‐14.1), median duration of response of 11.5 months (95%‐CI: 5.7‐30.4), and a median progression‐free survival of 7.2 months (95%‐CI: 5.5‐12.5). The most common toxicity was hematologic with grades 3‐4 anemia, neutropenia, and thrombocytopenia documented in 15% (8/55), 22% (12/55), and 33% (18/55), respectively. There were no cases of febrile neutropenia, and eight patients discontinued therapy because of adverse events. Everolimus monotherapy is a valid therapeutic option in the relapsed and/or refractory indolent non‐Hodgkin lymphoma patients and is well tolerated.
Anwendungen der Wittig‐Still‐Umlagerung in der organischen Synthese
Authors: Rycek Lukas , Hudlicky Tomas 
Published: February 2017

AbstractDieser Aufsatz zeichnet die Entstehung der Wittig‐Still‐Umlagerung und deren Anwendung in der organischen Synthese nach. Ihre Beziehung zur Wittig‐Umlagerung wird diskutiert, einhergehend mit einer detaillierten Analyse der E/Z‐Selektivität und Diastereoselektivität. Modifikationen der in Wittig‐Still‐Umlagerungen gebildeten Produkte werden im Zusammenhang der gesteigerten Komplexität von Intermediaten mit potenziellem Nutzen für die zielorientierte Synthese erläutert. Frühe Anwendungen der Wittig‐Still‐Umlagerung zur Modifizierung von Steroiden werden ebenso besprochen wie Anwendungen in der Naturstoffsynthesen von Alkaloiden und Terpenen sowie der Synthese sonstiger Verbindungen. Nach unserem besten Wissen ist die Literatur bis Dezember 2016 abgedeckt.
Palladium‐Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals
Authors: Sau Abhijit , Williams Ryan , Palo‐Nieto Carlos , Franconetti Antonio , Medina Sandra , Galan M. Carmen 
Published: February 2017

AbstractPalladium(II) in combination with a monodentate phosphine ligand enables the unprecedented direct and α‐stereoselective catalytic synthesis of deoxyglycosides from glycals. Initial mechanistic studies suggest that in the presence of N‐phenyl‐2‐(di‐tert‐butylphosphino)pyrrole as the ligand, the reaction proceeds via an alkoxy palladium intermediate that increases the proton acidity and oxygen nucleophilicity of the alcohol. The method is demonstrated with a wide range of glycal donors and acceptors, including substrates bearing alkene functionalities.
Catalytic Asymmetric Intramolecular [4+2] Cycloaddition of In Situ Generated ortho‐Quinone Methides
Authors: Xie Youwei , List Benjamin 
Published: February 2017

AbstractHerein, we describe the first catalytic asymmetric intramolecular [4+2] cycloaddition of in situ generated ortho‐quinone methides. In the presence of a confined chiral imidodiphosphoric acid catalyst, various salicylaldehydes react with dienyl alcohols to give transient ortho‐quinone methide intermediates, which undergo an intramolecular [4+2] cycloaddition to provide highly functionalized furanochromanes and pyranochromanes in excellent diastereoselectivity and enantioselectivity.
Effect of lipophilicity of wingtip groups on the anticancer potential of mono N‐heterocyclic carbene silver(I) complexes: Synthesis, crystal structures and in vitro anticancer study
Authors: Fatima Tabinda , Haque Rosenani A. , Razali Mohd R. , Ahmad Ashfaq , Asif Muhammad , Khadeer Ahamed Mohamed B. , Abdul Majid A. M. S. 
Published: February 2017

A series of symmetrically n‐alkyl‐substituted mono benzimidazolium salts with steady increase in n‐alkyl chain length have been prepared by stepwise N‐alkylation resulting in salts (1–8). The mono N‐heterocyclic carbene (NHC)–Ag(I) complexes (9–16) derived from the respective salts were readily accessible by in situ deprotonation using Ag2O. All the salts and the complexes were characterized using Fourier transform infrared, 1H NMR, 13C NMR and elemental analyses. Furthermore, the structures of salts 3 and 7 and complex 16 were elucidated using X‐ray crystallography, which established that this mono NHC–Ag(I) complex has a linear bis‐carbene arrangement (C2–Ag). The proligands and the respective Ag(I) complexes were studied for their in vitro anticancer potential against human colon cancer cell line (HCT‐116) using 5‐fluorouracil as a standard. From the IC50 values of all the tested compounds, it can be postulated that there is an influential relationship between the increase in chain length of the wingtip n‐alkyl groups and the anticancer potential. The proligands 4–8 and their respective complexes 12–16 with long n‐alkyl chain lengths (n = 6–10) showed better IC50 values (0.3–3.9 μM) than the standard drug with the complexes displaying markedly better antiproliferation activity against HCT‐116 cell line than the respective proligands and the standard drug (IC50 = 10.2 μM).
Impact of six versus 12 months of dual antiplatelet therapy in patients with drug‐eluting stent implantation after risk stratification with the residual SYNTAX score: Results from a secondary analysis of the I‐LOVE‐IT 2 trial
Authors: Qiu Miaohan , Li Yi , Li Jing , Xu Kai , Jing Quanmin , Dong Shaohong , Jin Zhe , Zhao Pitian , Xu Bo , Han Yaling 
Published: February 2017

BackgroundThe optimal duration of dual antiplatelet therapy (DAPT) after drug‐eluting stent (DES) implantation remains undetermined, especially for those at high risk of cardiac events postprocedure.ObjectivesThis study was aimed to investigate the impact of 6 versus 12 months of DAPT after DES implantation based on risk stratification with the residual SYNTAX score (rSS).MethodsA total of 2737 patients in the I‐LOVE‐IT 2 trial were grouped according to rSS status (low rSS [rSS = 0, n = 1474] versus high rSS [rSS > 0, n = 1263]) and DAPT duration (6 months vs. 12 months). The primary endpoint was 12‐month target lesion failure (TLF), and the major secondary endpoints were 12‐month net adverse clinical events (NACE) and major bleeding.ResultsIncidences of TLF (5.2 vs. 7.4%, P = 0.01) and NACE (9.2 vs. 13.4%, P < 0.001) at 12 months were significantly higher in patients with high rSSs compared with patients with low rSSs. Landmark analysis showed that, in patients with high rSS, 12‐month DAPT was associated with slightly lower risks of TLF (3.0% vs. 1.6%, P = 0.08) and NACE (7.0 vs. 4.4%, P = 0.054) compared with 6‐month DAPT within 6 to 12 months after PCI. Patients with different DAPT durations had similar risks of bleeding both in the low and high rSS groups.ConclusionsPatients with high rSSs have an increased risk of TLF and NACE at 12 months after DES implantation. Twelve‐month DAPT might be superior to 6‐month DAPT in patients with high rSS for reducing adverse events within 6 to 12 months after PCI without excessive risk of bleeding. © 2017 Wiley Periodicals, Inc.
Catheter ablation of hemodynamically unstable ventricular tachycardia in ischemic cardiomyopathy using high‐resolution mapping
Authors: Kaiser Lukas , Jularic Mario , Akbulak Ruken Özge , Nührich Jana , Willems Stephan , Meyer Christian 
Published: February 2017

Key Clinical MessageCatheter ablation is a recommended therapy option for ventricular tachycardia (VT). The antegrade transseptal approach for targeting VT with left ventricular origin is feasible with the high‐resolution basket catheter. High‐resolution mapping offers the potential to quickly acquire detailed voltage and activation maps. This may help to identify the crucial VT‐substrate even in patients with huge scar areas and hemodynamically unstable VT.
Patterns of computed tomography surveillance in survivors of colorectal cancer at Veterans Health Administration facilities
Authors: Sehdev Amikar , Sherer Eric A. , Hui Siu L. , Wu Jingwei , Haggstrom David A. 
Published: February 2017

BACKGROUNDAnnual computed tomography (CT) scans are a component of the current standard of care for the posttreatment surveillance of survivors of colorectal cancer (CRC) after curative‐intent resection. The authors conducted a retrospective study with the primary aim of assessing patient, physician, and organizational characteristics associated with the receipt of CT surveillance among veterans.METHODSThe Department of Veterans Affairs Central Cancer Registry was used to identify patients diagnosed with AJCC collaborative stage I to III CRC between 2001 and 2009. Patient sociodemographic and clinical (ie, CRC stage and comorbidity) characteristics, provider specialty, and organizational characteristics were measured. Hierarchical multivariable logistic regression models were used to assess the association between patient, provider, and organizational characteristics on receipt of 1) consistently guideline‐concordant care (at least 1 CT every 12 months for both of the first 2 years of CRC surveillance) versus no CT receipt and 2) potential overuse (>1 CT every 12 months during the first 2 years of CRC surveillance) of CRC surveillance using CT. The authors also analyzed the impact of the 2005 American Society of Clinical Oncology update in CRC surveillance guidelines on care received over time.RESULTSFor 2263 survivors of stage II/III CRC who were diagnosed after 2005, 19.4% of patients received no surveillance CT, whereas potential overuse occurred in both surveillance years for 14.9% of patients. Guideline‐concordant care was associated with younger age, higher stage of disease (stage III vs stage II), and geographic region. In adjusted analyses, younger age and higher stage of disease (stage III vs stage II) were found to be associated with overuse. There was no significant difference in the annual rate of CT scanning noted across time periods (year ≤ 2005 vs year > 2005).CONCLUSIONSAmong a minority of veteran survivors of CRC, both underuse and potential overuse of CT surveillance were present. Patient factors, but no provider or organizational characteristics, were found to be significantly associated with patterns of care. The 2005 change in American Society of Clinical Oncology guidelines did not appear to have an impact on rates of surveillance CT. Cancer 2017;123:2338–2351. © 2017 American Cancer Society.