bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professional medical writing support and the reporting quality of randomized controlled trial abstracts among high-impact general medical journals
Authors: Mills Ira , Sheard Catherine , Hays Meredith , Douglas Kevin , Winchester Christopher C. , Gattrell William T. 
Published: September 2017

Background: In articles reporting randomized controlled trials, professional medical writing support is associated with increased adherence to Consolidated Standards of Reporting Trials (CONSORT). We set out to determine whether professional medical writing support was also associated with improved adherence to CONSORT for Abstracts.Methods: Using data from a previously published cross-sectional study of 463 articles reporting randomized controlled trials published between 2011 and 2014 in five top medical journals, we determined the association between professional medical writing support and CONSORT for Abstracts items using a Wilcoxon rank-sum test.Results: The mean proportion of adherence to CONSORT for Abstracts items reported was similar with and without professional medical writing support (64.3% vs 66.5%, respectively; p=0.30). Professional medical writing support was associated with lower adherence to reporting study setting (relative risk [RR]; 0.40; 95% confidence interval [CI], 0.23–0.70), and higher adherence to disclosing harms/side effects (RR 2.04; 95% CI, 1.37–3.03) and funding source (RR 1.75; 95% CI, 1.18–2.60).Conclusions: Although professional medical writing support was not associated with increased overall adherence to CONSORT for Abstracts, important aspects were improved with professional medical writing support, including reporting of adverse events and funding source. This study identifies areas to consider for improvement.
A 13-Steroid Serum Panel Based on LC-MS/MS: Use in Detection of Adrenocortical Carcinoma
Authors: Taylor David R , Ghataore Lea , Couchman Lewis , Vincent Royce P , Whitelaw Ben , Lewis Dylan , Diaz-Cano Salvador , Galata Gabriele , Schulte Klaus-Martin , Aylwin Simon , Taylor Norman F 
Published: September 2017

Abstract

BACKGROUND
Adrenocortical carcinoma (ACC) is a rare malignancy, with an annual incidence of 1 or 2 cases per million. Biochemical diagnosis is challenging because up to two-thirds of the carcinomas are biochemically silent, resulting from de facto enzyme deficiencies in steroid hormone biosynthesis. Urine steroid profiling by GC-MS is an effective diagnostic test for ACC because of its capacity to detect and quantify the increased metabolites of steroid pathway synthetic intermediates. Corresponding serum assays for most steroid pathway intermediates are usually unavailable because of low demand or lack of immunoassay specificity. Serum steroid analysis by LC-MS/MS is increasingly replacing immunoassay, in particular for steroids most subject to cross-reaction.

METHODS
We developed an LC-MS/MS method for the measurement of serum androstenedione, corticosterone, cortisol, cortisone, 11-deoxycorticosterone, 11-deoxycortisol, 21-deoxycortisol, dehydroepiandrosterone sulfate, pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, and testosterone. Assay value in discriminating ACC from other adrenal lesions (phaeochromocytoma/paraganglioma, cortisol-producing adenoma, and lesions demonstrating no hormonal excess) was then investigated.

RESULTS
In ACC cases, between 4 and 7 steroids were increased (median = 6), and in the non-ACC groups, up to 2 steroids were increased. 11-Deoxycortisol was markedly increased in all cases of ACC. All steroids except testosterone in males and corticosterone and cortisone in both sexes were of use in discriminating ACC from non-ACC adrenal lesions.

CONCLUSIONS
Serum steroid paneling by LC-MS/MS is useful for diagnosing ACC by combining the measurement of steroid hormones and their precursors in a single analysis.
Public Presentation of Non-European Cultures At the Turn of the 19th and 20th Centuries. Part 1: An Analysis of the Collection of Vráz’S Glass Slides in the Photographic Collections of the Náprstek Museum
Authors: Todorovová Jiřina 
Published: September 2017

Abstract
The way in which the Czech public in the late 19th and early 20th centuries learned about exotic lands was primarily dependent on travellers’ abilities to present their findings in literature or to mediate their experiences directly, by means of lectures. From the 1890s onwards, lectures were accompanied by slideshows. The Náprstek Museum contains an extensive collection of glass slides from the estate of Enrique Stanko Vráz (1860-1932), and an analysis of this collection forms the basis of this contribution. The slides with which Vráz accompanied his lectures can be divided into three types: slides produced from Vráz’s own negatives, slides created from other sources and slides from educational series, manufactured and sold by professional companies.
Associations between body weight status, psychological well-being and disordered eating with intuitive eating among Malaysian undergraduate university students
Authors: Gan Wan Ying , Yeoh Wei Ching 
Published: September 2017

Abstract
Intuitive eating, which can be defined as reliance on physiological hunger and satiety cues to guide eating, has been proposed as a healthy weight management strategy. To date, there has not been a published study on intuitive eating in the context of Malaysia. Therefore, this cross-sectional study aims to determine associations between body weight status, psychological well-being and disordered eating behaviors with intuitive eating among undergraduate university students. A total of 333 undergraduate respondents (21.3% males and 78.7% females) from three randomly selected faculties in a public university in Malaysia participated in this study. Respondents completed a self-administered questionnaire which featured socio-demographic characteristics, intuitive eating, self-esteem, body appreciation, general unconditional acceptance, body acceptance by others, body function and disordered eating. Body weight, height, body fat percentage and waist circumference were measured. The results from this study revealed that there was no difference (t = 0.067, p = 0.947) in intuitive eating scores between males (75.69 ± 7.16) and females (75.62 ± 7.90). Multiple linear regression results have shown that body appreciation (β = 0.385, p < 0.001) and disordered eating (β = −0.168, p = 0.001) were significant predictors of intuitive eating, which accounted for 19.6% of the variance in intuitive eating. Health promotion programs should highlight the importance of enhancing body appreciation and preventing disordered eating behaviors among university students in order to promote intuitive eating as one of the healthy weight management approaches.
Helping Working Children through Consumocratic LawA Global South Perspective
Authors: Dumas P. Martin 
Published: September 2017

AbstractOn the basis of an in-depth case study of a transnational governance scheme driven by consumers and designed to fight child labour in Southern Asia – RugMark (now GoodWeave), co-founded by Peace Nobel Prize recipient Kailash Satyarthi – we identify and describe a number of characteristics peculiar to the consumocratic system of regulation, before examining the impact of information transparency within it. A number of theoretical scenarios emerge from the identification of four critical factors in the regulation of the societal information shared with consumocrats: (1) the degree of subjective veracity and comprehensiveness of available information; (2) the more or less comforting nature of this information; (3) the culminating outcomes to which it refers; and (4) its degree of objective veracity. All societal information is not theoretically bound to convey comforting messages to consumers inclined to consider the well-being of others. This message, while accurately reflecting the results achieved by local consumocratic organisations, may as well reflect the more or less controversial choices made in the pursuit of desirable goals, such as improving the fate of working children. It could also shed light on the flaws (e. g., ethical, technical, managerial) of this system of regulation by exposing its own limits to a better informed public. By opting for the transmission of messages subject to public controversy or worth a mea-culpa, the local regulators of this information would inevitably confront some risks (e. g., judicial, economic, socio-organisational). Under which conditions could these risks be reasonably taken? Quid of their likely impact on altruistic dispositions? From a pragmatic and Global South perspective, a non-paternalist analysis of transparency as a regulatory tool, it is shown, leads to recognising the utility of repositioning consumocratic activity on original, constitutional foundations, before envisaging the development of increasingly transparent and efficient tools in this regard.
On the relation between (verbal and kinesic) downtoning and illocution type
Authors: Schoonjans Steven 
Published: September 2017

Abstract“Downtoning” can be understood as the nuancing of an utterance in view of the interlocutor’s reaction. Typical downtoners in German include the so-called modal particles, although downtoning can also be expressed in other ways, including at the non-verbal level by means of gestures. Given their meanings, downtoning elements are typically restricted to particular illocution types. The goal of this paper is to investigate how this link between downtoning and illocution type is reflected in the use of these downtoners. This is done for both verbal and gestural downtoners in German and for downtoning patterns in German Sign Language (DGS). The question is addressed from two points of view, looking first at the topology of the downtoners in German and DGS, then at the kind of gestural markers co-occurring with verbal downtoners in German.
Neurodevelopment of HIV-Exposed and HIV-Unexposed Uninfected Children at 24 Months
Authors: Chaudhury Sumona , Williams Paige L. , Mayondi Gloria K. , Leidner Jean , Holding Penny , Tepper Vicki , Nichols Sharon , Magetse Jane , Sakoi Maureen , Moabi Kebaiphe , Makhema Joseph , Mdluli Charlotte , Jibril Haruna , Seage George R. , Kammerer Betsy , Lockman Shahin 
Published: September 2017

BACKGROUND:We sought to determine if HIV-exposed uninfected (HEU) children had worse neurodevelopmental outcomes at 24 months compared with HIV-unexposed uninfected (HUU) children in Botswana.METHODS:HIV-infected and uninfected mothers enrolled in a prospective observational study (“Tshipidi”) in Botswana from May 2010 to July 2012. Child neurodevelopment was assessed at 24 months with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III: cognitive, gross motor, fine motor, expressive language, and receptive language domains) and the Development Milestones Checklist (DMC), a caregiver-completed questionnaire (locomotor, fine motor, language and personal-social domains). We used linear regression models to estimate the association of in-utero HIV exposure with neurodevelopment, adjusting for socioeconomic and maternal health characteristics.RESULTS:We evaluated 670 children (313 HEU, 357 HUU) with ≥1 valid Bayley-III domain assessed and 723 children (337 HEU, 386 HUU) with a DMC. Among the 337 HEU children with either assessment, 122 (36%) were exposed in utero to maternal 3-drug antiretroviral treatment and 214 (64%) to zidovudine. Almost all HUU children (99.5%) breastfed, compared with only 9% of HEU children. No domain score was significantly lower among HEU children in adjusted analyses. Bayley-III cognitive and DMC personal-social domain scores were significantly higher in HEU children than in HUU children, but differences were small.CONCLUSIONS:HEU children performed equally well on neurodevelopmental assessments at 24 months of age compared with HUU children. Given the global expansion of the HEU population, results suggesting no adverse impact of in-utero HIV and antiretroviral exposure on early neurodevelopment are reassuring.
Standarization of a Protocol of Immunohistochemistry for the Detection of Brain Microglia in Wistar Rats
Authors: Ramírez Chan DDS, MSc, PhD Karol , Jaime Fornaguera-Trías PhD Jaime 
Published: September 2017

Objective: Standardize a protocol of immunohistochemistry that has been widely used in C57BL/6J mice to identify microglia of the central nervous system in Wistar rats. Materials and Methods: This research activity was carried out in two parts. In the first part, a protocol of immunohistochemistry was implemented to identify microglia in the central nervous system of 6 Wistar rats. A primary antibody with reactivity to rat and a specific secondary antibody to the primary were used. Once the protocol was established in rats' brains, an immunological challenge was produced with the intraperitoneal application of lipopolysaccharide in 2 Wistar rats, in order to evidence the changes in microglia morphology. Results and Discussion: We demonstrate that without making major modifications to the original protocol, it can also be used to identify microglia in adult Wistar rats. In the near future, this immunostaining protocol will be applied to elucidate the bidirectional interaction between the brain and the immune system, under homeostatic conditions and different physiological and pathological stimuli.
Evaluación clínica objetiva y estructurada (ECOE) en la maestría de Enfermería Ginecobstétrica y Perinatal: una sistematización de la experiencia
Authors: López Quirós Laura 
Published: September 2017

En busca de la excelencia profesional, la maestría en Enfermería Ginecológica, Obstétrica y Perinatal de la Universidad de Costa Rica, se mantiene a la vanguardia respecto de los procesos de enseñanza y aprendizaje. La inclusión de la simulación clínica forma parte de estas innovaciones educativas desde el año 2012; sin embargo esta es la primera vez que se incluye los procesos evaluativos de tipo ECOES los cuales, en experiencias internacionales, han demostrado pertinencia en el cumplimiento de los objetivos de enseñanza. Esta experiencia se sistematiza, según los cinco tiempos que Óscar Jara establece en su libro Para sistematizar experiencias, con el objetivo de definir la pertinencia del ECOE en cuanto a cumplir los objetivos de aprendizaje del curso. La profesora del curso y la autora recopilaron la experiencia en un diario de registro que incluye la elaboración de los escenarios, y la creación de las rubricas de evaluación. Además las estaciones fueron grabadas. La evaluación se llevó a cabo con la totalidad de estudiantes matriculados, en el curso de Enfermería Ginecoobstétrica y Perinatal I. Se estableció tres estaciones que permitirían evaluar aspectos teóricos, habilidades técnicas y sociales en la atención de las personas. Además, se creó rúbricas de evaluación, basadas en guías clínicas procedimentales y en protocolos de atención de la seguridad social costarricense. Se concluye que la experiencia demuestra clara pertinencia de los ECOEs, para evaluar la aplicación de conocimientos teóricos y habilidades psicomotoras, sociales y de comunicación en estudiantes que cursan la maestría y evidencia su preparación para continuar con los niveles más complejos de la carrera.
Zyanose bei einem Kalb mit einem Double Outlet Right Ventricle
Authors: Hildebrandt Nicolai , Henrich Manfred , Henrich Estelle , Schneider Matthias , Wiedemann Nicola 
Published: September 2017

ZusammenfassungEin 4 Tage altes, weibliches Holstein-Friesian-Kalb wurde zur Abklärung von Zyanose und Dyspnoe vorgestellt. Auskultatorisch bestanden ein deutlich verschärftes bronchovesikuläres Atemgeräusch und ein Herzgeräusch Grad IV/VI über der Trikuspidalklappe. Bei der Echokardiographie zeigte sich eine Dextroposition der Aorta im Sinne eines Double Outlet Right Ventricle (> 50% entspringen aus dem rechten Ventrikel). Es lagen zwei große ventrikuläre Septumdefekte und ein Aneurysma-ähnlicher Atriumseptumdefekt vor. Der erste Ventrikelseptumdefekt befand sich im perimembranösen, subpulmonalen Anteil und führte zu einem Übertritt von sauerstoffarmem Blut in die Aorta. Der andere lag entfernt im muskulären Anteil des Septums. Zudem konnte ein großer persistierender Ductus arteriosus dargestellt werden. Die Pulmonalarterie war hochgradig erweitert ohne Vorliegen einer Stenose. Die Befunde ließen sich mittels Angiographie verifizieren. Hierbei fiel zusätzlich auf, dass die Aorta ascendens bis zum Abgang des persistierenden Ductus arteriosus diffus hypoplastisch war. In der anschließenden pathologischen Untersuchung konnten die Befunde bestätigt werden.
Direito à saúde e Unidades de Tratamento Intensivo Neonatal (UTINs): uma breve reflexão sobre a eficácia das decisões judiciais no Estado do Maranhão
Authors: Ramos Edith Maria Barbosa , Sousa Lidia Cunha Schramm de 
Published: September 2017

Resumo: A judicialização das políticas públicas de saúde é um fenômeno crescente em todo o País, tendo diversos âmbitos do Poder Judiciário recebido demandas relacionadas à saúde, no entanto, percebe-se que essa discussão tem reflexos nos três Poderes. O presente artigo teve por escopo compreender o sistema normativo que regulamenta o acesso a leitos de Unidades de Tratamento Intensivo Neonatal (UTINs), bem como analisar a eficácia das decisões judiciais no Maranhão, com foco nas decisões de magistrados da 1ª Vara da Infância e Juventude da comarca de São Luís, MA. Realizou-se um estudo descritivo e exploratório, com levantamento bibliográfico e documental, notadamente, em documentos disponibilizados nos sites do Poder Judiciário maranhense, do Ministério da Saúde, Secretaria de Saúde do Estado do Maranhão e do Município de São Luís. Ao fim, foram feitas algumas considerações sobre a problemática da judicialização da saúde como fenômeno que expõe as fragilidades e as descontinuidades das ações desenvolvidas pelas casas legislativas, pela gestão pública e pelo próprio sistema de justiça.Palavras-chave: Direito à saúde. Unidade de tratamento intensivo. Poder Judiciário. Abstract: The legalization of public health policies is a growing phenomenon throughout the country, having many areas of the Judiciary received demands related to health, however, it is clear that this discussion is reflected in the three Branches. This article had the scope to understand the legal system that regulates access to the Neonatal Intensive Care Unit beds (NICUs) and to analyze the effectiveness of judgments in Maranhão, focusing on judges decisions of the 1st Court of Childhood and Youth of the district of São Luís, MA. We conducted a descriptive study, with bibliographic and documental survey, notably in documents available on the websites of the judiciary of Maranhão, the Ministry of Health, Health Secretariat of the State of Maranhão, and the City of São Luís. In the end, some considerations were made about the problem of the judicialisation of health as a phenomenon that exposes the weakness and discontinuity of the actions developed by legislative bodies, public management and own justice system.Keywords: Right to health. Neonatal Intensive Care Unit. Judicial Branch.
Editorial
Authors: Santos Gildenir Carolino 
Published: September 2017

Com muita satisfação, abrimos o ano de 2010 com este número especial: “Psicanálise e Filosofia: um diálogo possível?”, composto por 15 trabalhos: cinco artigos, nove textos do dossiê e um relato de experiência. Trataremos da representatividade de duas áreas do campo do conhecimento: a Psicanálise e a Filosofia. Nos diálogos traçados neste número especial, vários autores trouxeram suas contribuições de diferentes localidades e países: Uruguai, Inglaterra e Brasil e, com isso, conseguimos idealizar uma capa de abertura da revista com os psicanalistas e os filósofos das áreas envolvidas, comentados nos diversos trabalhos deste número: Jacques Lacan, Sigmund Freud, Michel Foucault, Gilles Deleuze e Friedrich Niestche, como elo entre os referidos autores nesse quebra-cabeça.
Pengembangan Media Ice Breaker Talking Pen pada Mata Pelajaran PAI Kelas X SMAN 100 Jakarta
Authors: Sulastri Ati , Mardhiah Izzatul , Ismail Yusuf 
Published: September 2017

This study aims to find out how to develop media ice breaker talking pen and media feasibility on the subjects of PAI. The research method used is Borg and Gall development model which includes requirement analysis, validation test, and test phase. The result of this development research is ice breaker talking pen media product which consists of command card and music developed through data collection, planning, product development, and validation and testing. Based on the validation results obtained the average score of the material experts of 4.75 (very good), and from the media experts of 3.78 (good), and the results of student responses about this media amounted to 4.39 or very good category. Therefore the ice breaker talking media on the eyes of learning PAI class X is declared eligible for use with very good category.
Keywords: Development Model Study, Ice Breaker Talking Pen, PAI
Abstrak
Penelitian ini bertujuan untuk mengetahui cara mengembangkan media ice breaker talking pen dan kelayakan media tersebut pada mata pelajaran PAI. Metode yang digunakan adalah model pengembangan Borg dan Gall yang meliputi analisis kebutuhan, tahap validasi dan tahap uji coba. Hasil penelitian pengembangan ini adalah produk media ice breaker talking pen yang terdiri dari kartu perintah dan musik yang dikembangkan melalui tahap pengumpulan data, perencanaan, pengembangan produk, serta validasi dan uji coba. Berdasarkan pada hasil validasi didapat skor rata-rata dari ahli materi sebesar 4,75 (sangat baik), dan dari ahli media sebesar 3,78 (baik). Serta hasil dari tanggapan siswa mengenai media ini sebesar 4,39 atau kategori sangat baik. Maka dari itu media ice breaker talking pen pada mata pelajaran PAI kelas X dinyatakan layak untuk digunakan dengan kategori sangat baik.
Kata Kunci : Pengembangan Model Pembelajaran, Ice Breaker Talking Pen, PAI