bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of adverse perinatal outcome by cerebroplacental ratio adjusted for estimated fetal weight
Authors: Sirico A. , Diemert A. , Glosemeyer P. , Hecher K. 
Published: March 2017

AbstractObjectivesTo evaluate the relationship between cerebroplacental ratio (CPR) and estimated fetal weight (EFW) in low‐ and high‐risk singleton pregnancies. Furthermore, we evaluated the role of CPR in the prediction of adverse perinatal outcome and whether CPR measurements adjusted for EFW improve its predictive value.MethodsThis was a retrospective cohort study including pregnancies in which Doppler investigations of umbilical artery (UA) and fetal middle cerebral artery (MCA) were performed at ≥ 30 weeks' gestation. Pregnancies were allocated to one of three groups according to EFW centile: small‐for‐gestational age (SGA) with EFW < 10th centile, appropriate‐for‐gestational age (AGA) and large‐for‐gestational age (LGA) with EFW > 90th centile. CPR was calculated as the ratio between the UA pulsatility index (PI) and MCA‐PI and converted to CPR multiples of the median (MoMs) according to the three EFW groups. Linear regression analysis was performed to evaluate the relationship between CPR‐MoMs and EFW centiles in low‐risk pregnancies. Furthermore, MoMs of CPR adjusted according to EFW centile (aCPR‐MoMs) were calculated. Adverse perinatal outcome was defined as presence of pathological cardiotocography (CTG) trace, arterial cord blood pH < 7.1, 5‐min Apgar score < 7 and presence of meconium‐stained amniotic fluid (MSAF).ResultsA total of 3515 (3016 low risk and 499 high risk) pregnancies, delivered between January 2010 and March 2016, were included. Linear regression analysis revealed a significant positive correlation between EFW centile and CPR‐MoM. Receiver–operating characteristics (ROC) curve analysis showed a significant association between CPR‐MoM and pathological CTG trace (AUC, 0.539; SD, 0.014; P = 0.005) and low Apgar score (AUC, 0.609; SD, 0.041; P = 0.008), but not with low arterial pH or MSAF. There was a significant association between aCPR‐MoM and pathological CTG trace (AUC, 0.540; SD, 0.014; P = 0.003), low arterial cord blood pH (AUC, 0.546; SD, 0.022; P = 0.035) and low Apgar score (AUC, 0.609; SD, 0.044; P = 0.008), but not with MSAF. However, detection rates for adverse perinatal outcomes by CPR‐MoM and aCPR‐MoM were low, ranging from 6.7% to 28.6% for SGA, 12.1% to 22.2% for AGA and 0% to 33.3% for LGA, for a false‐positive rate of 10%. In a subgroup analysis of cases in which ultrasound examination was performed at ≥ 34 weeks of gestation and within 4 weeks of delivery (n = 1439), the ROC curves for aCPR‐MoM were significantly associated with all four outcomes evaluated.ConclusionsCPR‐MoM values are dependent on EFW centiles; therefore, we suggest that CPR‐MoM should be adjusted for EFW centile. However, both CPR‐ and aCPR‐MoM showed a low prediction rate for adverse perinatal outcome. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Protocol for the prospective validation study: ‘Screening programme for pre‐eclampsia’ (SPREE)
Authors: Tan M. Y. , Koutoulas L. , Wright D. , Nicolaides K. H. , Poon L. C. Y. 
Published: March 2017

ABSTRACTPre‐eclampsia (PE), which affects about 2% of pregnancies, is a major cause of maternal and perinatal morbidity and mortality. Early detection of PE can improve pregnancy outcome by providing timely intervention and closer monitoring. The current guideline from the UK National Institute for Health and Care Excellence (NICE) recommends that, at the booking visit, women identified with one major risk factor or more than one moderate risk factor for PE should be advised to take low‐dose aspirin daily from 12 weeks until delivery. However, performance of the current method of screening is poor and identifies only about 35% of PE. Extensive studies in the last decade have established that the best performance for early prediction of PE can be achieved by using a novel Bayes' theorem‐based method that combines maternal characteristics and medical history together with measurements of mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI), serum placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A) at 11–13 weeks' gestation. This forms the ‘combined test’, which could be simplified to the ‘mini combined test’ when only maternal factors, MAP and PAPP‐A are taken into consideration.We present the protocol (version 3.1, 14 November 2016) for the ‘Screening programme for pre‐eclampsia’ (SPREE) study, a prospective multicenter cohort study that will be carried out in seven National Health Service maternity hospitals in England. Eligible pregnant women attending their routine scan at 11–13 weeks' gestation will be invited to participate in this study. Maternal characteristics and history and measurements of MAP, UtA‐PI, serum PAPP‐A and PlGF will be recorded according to standardized protocols. The patient‐specific risk for PE will be calculated and data on pregnancy outcomes collected. We hypothesize that the first‐trimester mini combined test and combined test for PE screening, using the Bayes' theorem‐based method, are likely to be superior to the current method recommended by NICE that is based on maternal demographics and history alone.Enrollment for the study commenced in April 2016. The study is registered on the International Standard Randomised Controlled Trial Number (ISRCTN) registry. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Seekers, Finders, Settlers, and Stumblers: Identifying the Career Paths of Males in the Genetic Counseling Profession
Authors: Chen Anthony , Veach Pat McCarthy , Schoonveld Cheri , Zierhut Heather 
Published: March 2017

AbstractGenetic counseling is a female‐dominated profession, with 96% of counselors self‐identifying as female. Research suggests gender diversification benefits healthcare professionals and the populations they serve. Therefore, this study explored how men choose a genetic counseling career, associations between career satisfaction and their career entry dynamics and experience levels, and differences due to experience level in how they decide on this profession. Twenty‐five novice, experienced, or seasoned male counselors and 8 male genetic counseling students participated in semi‐structured phone interviews. Interpretive content and cross‐case analyses of interview data were informed by Simpson's “Seekers, Finders, and Settlers” theory describing career entry dynamics of men in non‐traditional (i.e., female‐dominated) fields. Results revealed 13 interviewees were Seekers, who initially knew they wanted a career in genetic counseling, actively chose the profession, and were satisfied with their decision. Eleven were Settlers, who had tried different, traditional jobs, with limited satisfaction before actively finding and choosing genetic counseling. Two were Finders, who discovered genetic counseling while in the career decision making process and made a passive choice to pursue it as they had no feasible, satisfactory alternative. Seven men fit a new category, we termed “Stumblers,” who were in another career and satisfied, but changed to genetic counseling after happening to hear about it. Prevalent themes pertaining to participants’ experiences in the career include desire for a multidisciplinary career; lack of a priori knowledge of genetic counselor roles; late exposure to the profession; and varied perceptions of being in a non‐traditional career. There were few differences due to experience level and career satisfaction was high across the sample. Results suggest earlier exposure to the career and availability of detailed descriptions of its multidisciplinary nature may increase the number of males in the profession.
Efficacy of nanoceria for periodontal tissues alteration in glutamate-induced obese rats—multidisciplinary considerations for personalized dentistry and prevention
Authors: Beregova Tetyana V. , Neporada Karine S. , Skrypnyk Maksym , Falalyeyeva Tetyana M. , Zholobak Nadiya M. , Shcherbakov Oleksandr B. , Spivak Mykola Ya. , Bubnov Rostyslav V. 
Published: March 2017

Abstract

Background
Nowadays, we face the global epidemic of obesity, that is known to contribute to the development of many diseases, such as the oral cavity pathologies. Dental and oral pathologies are frequently caused by and overlapped with systemic multifactorial diseases such as obesity being its early indicators and risk factors.
The aim was to study the influence of nanoceria on periodontal tissues alteration in glutamate (MSG)-induced obese rats.

Methods
We included 52 Wistar rats of both genders and divided into four groups: newborn rats in group 1 (control) received subcutaneously 8 μl/g saline. Group 2 received 3 to 4 mg/g MSG subcutaneously on the second, fourth, sixth, eighth, and tenth day of life; group 3—intragastric administration of nanocrystalline cerium dioxide at a dose of 1 mg/kg volume of 2.9 ml/kg against the background of glutamate-induced obesity; the fourth group of animals was treated with a solution of sodium citrate intragastric volume of 2.9 ml/kg (solvent of nanocrystalline cerium). We determined the total proteolytic activity, the total antitrypsin activity, the content-free fucose and glycosaminoglycanes (GAG), content of TBA-active of products, the content of oxidation-modified proteins (OMB), and catalase activity in the homogenate of soft periodontal tissues of rats.

Results
Intragastric injection of nanoceria prevents activation of proteolytic processes, reducing the catabolism of glycoproteins and proteoglycans of periodontal tissue in MSG-induced obese rats. Injection of nanoceria prevents activation of proteolytic processes, significantly decreases the total proteolytic activity, and inhibits the activation of free radical oxidation in periodontal tissues of rats compared with MSG-induced obesity model without corrections. Further, it significantly increases the total antitrypsin activity in periodontal tissues by 1.7 times, TBA-reagents by 1.7 times, and content of OMB by 1.4 times compared with glutamate-induced obese animals.

Conclusions
MSG-induced obesity triggers periodontal tissue alterations in the rat model. Nanoceria contributes to the corrections of pathological changes in periodontal tissues in glutamate-induced obese rats via balancing protein-inhibitory capacity and reducing the depolymerization of fucosylated proteins and proteoglycans and antioxidative activity.
Relations between harsh discipline from teachers, perceived teacher support, and bullying victimization among high school students
Authors: Banzon‐Librojo Lorelie Ann , Garabiles Melissa R. , Alampay Liane Peña 
Published: March 2017

ABSTRACTThis study examined how the experience of harsh discipline from teachers is related to students' experience of bullying victimization in a Philippine high school. Respondents were 401 first‐ to fourth‐year high school students of an urban public school in the Philippines. Using structural equation modeling, a hypothesized model with direct associations between harsh discipline and bullying victimization, and an indirect path via students' perception of teacher support, was tested. The data adequately fit the model and showed that experiences of harsh teacher discipline predicted higher bullying victimization and students' negative perception of teacher support. There were no significant indirect effects. The findings suggest that school discipline strategies may have repercussions on students' behaviors and relationships, highlighting the teacher's role in modeling and setting norms for acceptable behaviors. Future studies can examine further how teachers' harsh or positive discipline behaviors relate to bullying.
The eIF3a Arg803Lys genetic polymorphism is associated with susceptibility to and chemoradiotherapy efficacy in cervical carcinoma
Authors: Xu Jia‐Zhen , Wen Fang , Wang Xian‐Rong 
Published: March 2017

AbstractWe aimed to explore the correlations between eukaryotic translation initiation factor 3, subunit A (eIF3a) polymorphisms and susceptibility to and chemoradiotherapy efficacy in cervical carcinoma. Between August 2007 and August 2011, 176 patients with cervical carcinoma were enrolled as the case group, and 180 healthy individuals were selected as the control group. eIF3a Arg803Lys C>T genotypes were detected by hemi‐nested polymerase chain reaction restriction fragment length polymorphism. All patients received chemoradiotherapy and were evaluated for efficacy. Compared with carriers of the CC genotype, carriers of the T genotype of the eIF3a Arg803Lys C>T polymorphism had a higher risk of cervical carcinoma. The eIF3a Arg803Lys C>T polymorphism was associated with tumor size, differentiation degree, Federation of Gynecology and Obstetrics (FIGO) stage, and lymph node metastasis (LNM). The overall response rate of the case group was 69.32% (122/176). The response rate of CC genotype carriers was higher compared to patients with the CT+TT genotypes. Binary‐logistic regression analysis showed that tumor size, FIGO stage, LNM, and the eIF3a Arg803Lys C>T polymorphism were influencing factors for chemoradiotherapy efficacy. Univariate analysis revealed that age, eIF3a Arg803Lys C>T polymorphism, differentiation degree, FIGO stage, and LNM were prognostic factors of cervical carcinoma, and multivariate analysis showed that age ≥ 60 years, higher FIGO stage, and LNM, as well as the CT and TT genotypes of the eIF3a Arg803Lys C>T polymorphism, were risk factors related to the prognosis of cervical carcinoma. The eIF3a Arg803Lys C>T polymorphism is connected with a higher susceptibility to cervical carcinoma and may affect chemoradiotherapy efficacy in and prognosis of cervical carcinoma.
On the irregular points for systems with the shadowing property
Authors: DONG YIWEI , OPROCHA PIOTR , TIAN XUETING 
Published: March 2017

We prove that when $f$ is a continuous self-map acting on a compact metric space $(X,d)$ that satisfies the shadowing property, then the set of irregular points (i.e., points with divergent Birkhoff averages) has full entropy. Using this fact, we prove that, in the class of $C^{0}$-generic maps on manifolds, we can only observe (in the sense of Lebesgue measure) points with convergent Birkhoff averages. In particular, the time average of atomic measures along orbits of such points converges to some Sinai–Ruelle–Bowen-like measure in the weak$^{\ast }$ topology. Moreover, such points carry zero entropy. In contrast, irregular points are non-observable but carry infinite entropy.
Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial
Authors: Paquette Martine , Medina Larqué Ana S. , Weisnagel S. J. , Desjardins Yves , Marois Julie , Pilon Geneviève , Dudonné Stéphanie , Marette André , Jacques Hélène 
Published: March 2017

AbstractPlant-derived foods rich in polyphenols are associated with several cardiometabolic health benefits, such as reduced postprandial hyperglycaemia. However, their impact on whole-body insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp technique remains under-studied. We aimed to determine the effects of strawberry and cranberry polyphenols (SCP) on insulin sensitivity, glucose tolerance, insulin secretion, lipid profile, inflammation and oxidative stress markers in free-living insulin-resistant overweight or obese human subjects (n 41) in a parallel, double-blind, controlled and randomised clinical trial. The experimental group consumed an SCP beverage (333 mg SCP) daily for 6 weeks, whereas the Control group received a flavour-matched Control beverage that contained 0 mg SCP. At the beginning and at the end of the experimental period, insulin sensitivity was assessed by a hyperinsulinaemic-euglycaemic clamp, and glucose tolerance and insulin secretion by a 2-h oral glucose tolerance test (OGTT). Insulin sensitivity increased in the SCP group as compared with the Control group (+0·9 (sem 0·5)×10−3v. −0·5 (sem 0·5)×10−3 mg/kg per min per pmol, respectively, P=0·03). Compared with the Control group, the SCP group had a lower first-phase insulin secretion response as measured by C-peptide levels during the first 30 min of the OGTT (P=0·002). No differences were detected between the two groups for lipids and markers of inflammation and oxidative stress. A 6-week dietary intervention with 333 mg of polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects but was not effective in improving other cardiometabolic risk factors.
Feeding byLeucopis argenticollisandLeucopis piniperda(Diptera: Chamaemyiidae) from the western USA onAdelges tsugae(Hemiptera: Adelgidae) in the eastern USA
Authors: Motley K. , Havill N.P. , Arsenault-Benoit A.L. , Mayfield A.E. , Ott D.S. , Ross D. , Whitmore M.C. , Wallin K.F. 
Published: March 2017

AbstractLeucopis argenticollis(Zetterstedt) andLeucopis piniperda(Malloch) are known to feed on the lineage ofAdelges tsugaeAnnand that is native to western North America, but it is not known if they will survive on the lineage that was introduced from Japan to the eastern USA. In 2014, westernLeucopisspp. larvae were brought to the laboratory and placed onA. tsugaecollected in either Washington (North AmericanA. tsugaelineage) or Connecticut (Japanese lineage). There were no significant differences in survival or developmental times between flies reared on the two different adelgid lineages. In 2015 and 2016, westernLeucopisspp. adults were released at two different densities onto enclosed branches ofA. tsugaeinfested eastern hemlock (Tsuga canadensis(L.) Carr.) in Tennessee and New York. Cages were recovered and their contents examined 4 weeks after release at each location.Leucopisspp. larvae and puparia of the F1 generation were recovered at both release locations and adults of the F1 generation were collected at the Tennessee location. The number ofLeucopisspp. offspring collected increased with increasing adelgid density, but did not differ by the number of adult flies released. Flies recovered from cages and flies collected from the source colony were identified asL.argenticollisandL. piniperdausing DNA barcoding. These results demonstrate thatLeucopisspp. from the Pacific Northwest are capable of feeding and developing to the adult stage onA. tsugaein the eastern USA and they are able to tolerate environmental conditions during late spring and early summer at the southern and northern extent of the area invaded byA. tsugaein the eastern USA.
Comparing electronic recording with a diagrammatic template versus traditional handwritten recording of tympanomastoid procedures: third audit cycle of 95 cases
Authors: Fang S , Habeeb A , Gluckman P , Kanegoankar R 
Published: March 2017

AbstractBackground:The middle ear and mastoid are complex three-dimensional structures and therefore tympanomastoid procedures require detailed documentation. Traditional written accounts can be inaccurate and difficult to interpret.Methods:This audit of 95 patients compares the completion of essential operative details using: an all-electronic version of a standardised proforma with a diagrammatic template, a non-electronic version with a diagrammatic template, and a traditional handwritten template.Results:The electronic template resulted in 81 per cent of essential operative items being recorded, compared to 78 per cent (p = 0.3) with a previous non-electronic template and 50 per cent (p = 0.0004) when using simple handwritten recording.Conclusion:An electronic proforma with a diagrammatic template improves the documentation and interpretation of tympanomastoid procedures compared to traditional handwritten records.
Intratympanic methylprednisolone perfusion as a salvage treatment for profound idiopathic sudden sensorineural hearing loss
Authors: Dai Y , Lu L , Hou J , Yang X , Li H , Yang Y , She W 
Published: March 2017

AbstractObjective:This study aimed to examine the effectiveness of intratympanic methylprednisolone perfusion as salvage treatment for profound idiopathic sudden sensorineural hearing loss.Methods:A retrospective clinical study of 97 patients with unilateral profound idiopathic sudden sensorineural hearing loss was performed. In all, 83 patients who received salvage intratympanic methylprednisolone perfusion plus conventional treatment (except for steroids) as the second-line therapy were assigned to the study group, while 14 patients who received conventional treatment alone were assigned to the comparison group.Results:In the study group, treatments in patients with a shorter interval from disease onset to intratympanic methylprednisolone perfusion (up to 15 days) had significantly greater improvements in the overall effective rate and pure tone average compared with patients with a longer interval (over 15 days). For patients with a short interval from disease onset to intratympanic methylprednisolone perfusion, those in the study group had significantly greater improvements in the overall effective rate and pure tone average compared with those in the comparison group. In both the study and comparison groups, hearing improvements were greater at low frequencies than at medium and high frequencies.Conclusion:The interval from disease onset to intratympanic methylprednisolone perfusion was the major factor affecting hearing recovery. Early second-line salvage intratympanic methylprednisolone perfusion significantly improved the degree of hearing recovery in profound idiopathic sudden sensorineural hearing loss patients after failure of systemic steroid treatment.
Diagnosis of toxoplasmosis in pregnancy. Evaluation of latex–protein complexes by immnunoagglutination
Authors: PERETTI LEANDRO E. , GONZALEZ VERÓNICA D. G. , MARCIPAR IVÁN S. , GUGLIOTTA LUIS M. 
Published: March 2017

SUMMARYThe aim of this work was to obtain a reagent based on latex particles for ruling out acute toxoplasmosis in pregnant women by immunoagglutination (IA). Latex–protein complexes (LPC) were previously synthesized coupling the recombinant protein ofToxoplasma gondiiP22Ag and the homogenate of the parasite to latex particles with different size, chemical functionality and charge density. LPC were tested in IA assays against a panel of 72 pregnant women serum samples. Results were analysed through receiver operating characteristic curves, determining area under the curve (AUC), sensitivity, specificity positive and negative predictive values (PPV and NPV, respectively). It was observed that the antigenicity of proteins was not affected during sensitization by either physical adsorption or covalent coupling. The best results in the sense of maximizing discrimination of low avidity sera from chronic ones were observed for the IA test based on latex particles with carboxyl functionality and the recombinant P22Ag, obtaining an AUC of 0·94, a sensitivity of 100% and a NPV of 100%. In this way, the proposed test could be useful for the toxoplasmosis diagnosis in pregnant women, with the advantages of being cheap, rapid and easy to be implemented.