bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistency of magnetoencephalographic functional connectivity and network reconstruction using a template versus native MRI for co‐registration
Authors: Douw Linda , Nieboer Dagmar , Stam Cornelis J. , Tewarie Prejaas , Hillebrand Arjan 
Published: October 2017

AbstractIntroductionStudies using functional connectivity and network analyses based on magnetoencephalography (MEG) with source localization are rapidly emerging in neuroscientific literature. However, these analyses currently depend on the availability of costly and sometimes burdensome individual MR scans for co‐registration. We evaluated the consistency of these measures when using a template MRI, instead of native MRI, for the analysis of functional connectivity and network topology.MethodsSeventeen healthy participants underwent resting‐state eyes‐closed MEG and anatomical MRI. These data were projected into source space using an atlas‐based peak voxel and a centroid beamforming approach either using (1) participants’ native MRIs or (2) the Montreal Neurological Institute's template. For both methods, time series were reconstructed from 78 cortical atlas regions. Relative power was determined in six classical frequency bands per region and globally averaged. Functional connectivity (phase lag index) between each pair of regions was calculated. The adjacency matrices were then used to reconstruct functional networks, of which regional and global metrics were determined. Intraclass correlation coefficients were calculated and Bland–Altman plots were made to quantify the consistency and potential bias of the use of template versus native MRI.ResultsCo‐registration with the template yielded largely consistent relative power, connectivity, and network estimates compared to native MRI.DiscussionThese findings indicate that there is no (systematic) bias or inconsistency between template and native MRI co‐registration of MEG. They open up possibilities for retrospective and prospective analyses to MEG datasets in the general population that have no native MRIs available. Hum Brain Mapp, 2017. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. Hum Brain Mapp 39:104–119, 2018. © 2017 Wiley Periodicals, Inc.
Depression hurts, depression costs: The medical spending attributable to depression and depressive symptoms in China
Authors: Hsieh Chee‐Ruey , Qin Xuezheng 
Published: October 2017

AbstractDue to its fast economic growth and lifestyle changes, China is experiencing a rapid epidemiological transition from communicable to noncommunicable diseases (NCDs). Mental disorder such as depression is an important yet often neglected NCD and is becoming a growing cause of disability, suicides, and disease burden. This paper provides the first nationally representative estimate of the medical cost attributable to depression and depressive symptoms among the adult population in China. On the basis of the 2012 China Family Panel Studies survey, our results indicate that these mental health conditions have significant impacts on the individual medical expenditure, and they jointly contribute to 14.7% of total personal expected medical spending in China, with depression and depressive symptoms accounting for 6.9% and 7.8%, respectively. Given that patients with mental illness face multiple psychological and institutional barriers in seeking appropriate treatment, the high depression‐induced medical costs may be primarily driven by the cost‐shifting effect from mental health care to general health care, as mental disorders often coexist with other NCDs such as diabetes and hypertension. As an implication, our study calls for an urgent reform of China's mental health and insurance systems to remove the policy‐induced obstacles for the access to mental health care resources.
Validation of the eighth edition American Joint Committee on Cancer staging system for human papillomavirus‐associated oropharyngeal cancer
Authors: Cramer John D. , Hicks Kate E. , Rademaker Alfred W. , Patel Urjeet A. , Samant Sandeep 
Published: October 2017

AbstractBackgroundThe eighth edition American Joint Committee on Cancer (AJCC) staging manual includes major changes in staging of oropharyngeal cancer (OPC). We evaluated the new staging system in order to validate this shift in classification.MethodsWe used the National Cancer Database (NCDB) to identify patients with human papillomavirus‐associated (HPV‐positive) OPC from 2010‐2013. We restaged patients using the eighth edition guidelines and compared them with those from the seventh edition. We calculated stage‐specific overall survival and concordance indices.ResultsWe identified 15 116 patients with a median follow‐up period of 29.1 months. Clinical and pathological staging changed for 93.9% and 91.7% of patients, respectively. Survival concordance indices for both clinical (0.621‐0.656) and pathological (0.640‐0.663) staging were improved in the eighth edition compared to the seventh edition.ConclusionThe eighth edition guidelines have profoundly altered staging of HPV‐positive OPC and seem to demonstrate improved survival discrimination.
A population‐based study of the effect of pregnancy history on risk of stillbirth
Authors: Räisänen Sari , Hogue Carol J.R. , Laine Katariina , Kramer Michael R. , Gissler Mika , Heinonen Seppo 
Published: October 2017

AbstractObjectiveTo examine the effect of pregnancy history on the risk of stillbirth.MethodsIn a population‐based cross‐sectional study, data were reviewed from all women aged at least 20 years with singleton pregnancies in Finland between 2000 and 2010. The primary outcome—stillbirth—was defined as fetal death after 22 gestational weeks or death of a fetus weighing at least 500 g.ResultsAmong 604 047 singleton pregnancies, the prevalence of stillbirth was 3.17 per 1000 deliveries. Prevalence was lowest for multiparous women without previous pregnancy loss after adjusting for major pregnancy complications associated with stillbirth (placenta previa, placental abruption, and pre‐eclampsia) and other confounders. Relative to these women, stillbirth prevalence was higher among multiparous women with previous spontaneous abortion and/or stillbirth (adjusted odds ratio [aOR] 1.20, 95% confidence interval [CI] 1.05–1.36), nulliparous women with no previous pregnancy loss (aOR 1.23, 95% CI 1.10–1.38), and nulliparous women with prior spontaneous abortion (aOR 1.43, 95% CI 1.18–1.74).ConclusionPrevious pregnancy loss was found to be an independent risk factor for stillbirth, irrespective of the number of prior deliveries.
Effects of exposure to six chemical ultraviolet filters commonly used in personal care products on motility of MCF‐7 and MDA‐MB‐231 human breast cancer cells in vitro
Authors: Alamer Maha , Darbre Philippa D. 
Published: October 2017

AbstractBenzophenone (BP)‐1, BP‐2, BP‐3, octylmethoxycinnamate (OMC), 4‐methylbenzilidenecamphor and homosalate are added to personal care products to absorb ultraviolet light. Their presence in human milk and their oestrogenic activity suggests a potential to influence breast cancer development. As metastatic tumour spread is the main cause of breast cancer mortality, we have investigated the effects of these compounds on migration and invasion of human breast cancer cell lines. Increased motility of oestrogen‐responsive MCF‐7 human breast cancer cells was observed after long‐term exposure (>20 weeks) to each of the six compounds at ≥10−7 m concentrations using three independent assay systems (scratch assay, live cell imaging, xCELLigence technology) and increased invasive activity was observed through matrigel using the xCELLigence system. Increased motility of oestrogen‐unresponsive MDA‐MB‐231 human breast cancer cells was observed after 15 weeks of exposure to each of the six compounds by live cell imaging and xCELLigence technology, implying the increased migratory activity was not confined to oestrogen‐responsive cells. Molecular mechanisms varied between compounds and cell lines. Using MCF‐7 cells, reduction in E‐cadherin was observed following 24 weeks' exposure to 10−5 m BP‐1 and 10−5 m homosalate, and reduction in β‐catenin was noted following 24 weeks' exposure to 10−5 m OMC. Using MDA‐MB‐231 cells, increased levels of matrix metalloproteinase 2 were observed after 15 weeks exposure to 10−7 m OMC and 10−7 m 4‐methylbenzilidenecamphor. Although molecular mechanisms differ, these results demonstrate that exposure to any of these six compounds can increase migration and invasion of human breast cancer cells.
Chemical warfare agent simulants for human volunteer trials of emergency decontamination: A systematic review
Authors: James Thomas , Wyke Stacey , Marczylo Tim , Collins Samuel , Gaulton Tom , Foxall Kerry , Amlôt Richard , Duarte‐Davidson Raquel 
Published: October 2017

AbstractIncidents involving the release of chemical agents can pose significant risks to public health. In such an event, emergency decontamination of affected casualties may need to be undertaken to reduce injury and possible loss of life. To ensure these methods are effective, human volunteer trials (HVTs) of decontamination protocols, using simulant contaminants, have been conducted. Simulants must be used to mimic the physicochemical properties of more harmful chemicals, while remaining non‐toxic at the dose applied. This review focuses on studies that employed chemical warfare agent simulants in decontamination contexts, to identify those simulants most suitable for use in HVTs of emergency decontamination. Twenty‐two simulants were identified, of which 17 were determined unsuitable for use in HVTs. The remaining simulants (n = 5) were further scrutinized for potential suitability according to toxicity, physicochemical properties and similarities to their equivalent toxic counterparts. Three suitable simulants, for use in HVTs were identified; methyl salicylate (simulant for sulphur mustard), diethyl malonate (simulant for soman) and malathion (simulant for VX or toxic industrial chemicals). All have been safely used in previous HVTs, and have a range of physicochemical properties that would allow useful inference to more toxic chemicals when employed in future studies of emergency decontamination systems.
Left ventricular twist is impaired in acromegaly: Insights from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study
Authors: Kormányos Árpád , Domsik Péter , Kalapos Anita , Orosz Andrea , Lengyel Csaba , Valkusz Zsuzsanna , Trencsányi Attila , Forster Tamás , Nemes Attila 
Published: October 2017

AbstractIntroductionAcromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age‐ and gender‐matched healthy controls.MethodsThe present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age‐ and gender‐matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men).ResultsIn 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so‐called LV “rigid body rotation” (RBR). Between all acromegalic patients without LV‐RBR and controls, both LV basal (–3.76 ± 1.73 vs. −6.17 ± 2.66°, P = .004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P = .001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P < .001) differed significantly. Between active and nonactive acromegaly subgroups, only the time‐to‐peak LV twist (377 ± 78 vs. 229 ± 97 ms, P = .005) showed significant difference.ConclusionsAcromegaly is associated with impaired LV rotation and twist as assessed by 3‐dimensional speckle tracking echocardiography. LV‐RBR is a frequent phenomenon in acromegaly.
The effect of unit, depth, and probe load on the reliability of muscle shear wave elastography: Variables affecting reliability of SWE
Authors: Alfuraih Abdulrahman M. , O'Connor Philip , Hensor Elizabeth , Tan Ai Lyn , Emery Paul , Wakefield Richard J. 
Published: October 2017

AbstractPurposeThere is currently no standardized method for muscle shear wave elastography (SWE). The objective of this study was to investigate the effect of unit of measurement, depth, and probe load on the reliability of muscle SWE.MethodsThe vastus lateralis, biceps femoris, biceps brachii, and abductor digiti minimi muscles were scanned on 20 healthy participants. The SWE readings were measured in shear wave velocity (m/s) and Young's modulus (kPa). Three acquisitions of varying depths were acquired from vastus lateralis. Minimal probe load was compared with the use of a standoff gel layer. Three repeated measurements were acquired to assess reliability using intraclass correlations (ICC).ResultsThe mean elasticity varied across muscle groups and ranged from 1.54 m/s for biceps femoris to 2.55 m/s for abductor digiti minimi (difference = 1.01 m/s [95% confidence interval, CI = 0.92, 1.10]). Reporting readings in meters per second resulted in higher ICC of 0.83 (0.65, 0.93) in comparison to 0.77 (0.52, 0.90) for kilopascal for the vastus lateralis muscle only. Variance increased proportionally with depth reaching 0.17 (equivalent to ±0.82 m/s) at 6 cm. Using a standoff gel decreased ICC to 0.63 (0.20, 0.84) despite similar mean elasticity readings to minimal probe load.ConclusionsDifferent acquisition and technical factors may significantly affect the reliability of SWE in skeletal muscles. Readings acquired in the unit of shear wave velocity (m/s) from depths less than 4 cm using a minimal probe load without a standoff gel yielded the best reliability.
Contrast‐enhanced transoral carotid ultrasonography for the diagnosis and follow‐up of extracranial internal carotid artery dissection: A case report
Authors: Hagiwara Yuta , Shimizu Takahiro , Hasegawa Yasuhiro 
Published: October 2017

AbstractA 56‐year‐old woman was admitted to our hospital because of amaurosis fugax. The carotid angiogram showed irregularly stenotic lesions of the left and right internal carotid arteries (ICAs), suggestive of dissection. Follow‐up evaluation was performed by transoral carotid ultrasonography (TOCU) with contrast enhancement (CE), which yielded better vessel lumen and intramural hematoma visualization than color Doppler imaging. CE‐TOCU is useful for evaluating ICA dissections that extends to the high cervical portion.
Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy
Authors: Liu Jinyun , Qu Yingmin , Wang Guoliang , Wang Xinyue , Zhang Wenxiao , Li Jingmei , Wang Zuobin , Li Dayou , Jiang Jinlan 
Published: October 2017

AbstractThis article studies the morphological and mechanical features of multinuclear and mononuclear SW480 colon cancer cells by atomic force microscopy to understand their drug‐resistance. The SW480 cells were incubated with the fullerenol concentrations of 1 mg/ml and 2 mg/ml. Morphological and mechanical features including the height, length, width, roughness, adhesion force and Young's modulus of three multinuclear cell groups and three mononuclear cell groups were imaged and analyzed. It was observed that the features of multinuclear cancer cells and mononuclear cancer cells were significantly different after the treatment with fullerenol. The experiment results indicated that the mononuclear SW480 cells were more sensitive to fullerenol than the multinuclear SW480 cells, and the multinuclear SW480 cells exhibited a stronger drug‐resistance than the mononuclear SW480 cells. This work provides a guideline for the treatments of multinuclear and mononuclear cancer cells with drugs.
Diabetes prevention in the real world: Insights from the JDPP and J‐DOIT1
Authors: Sakane Naoki 
Published: October 2017

AbstractType 2 diabetes (T2D) is associated with increased risks of morbidity and mortality. Diabetes prevention is an urgent issue in Japan. The Finnish Diabetes Prevention Study and US Diabetes Prevention Program revealed that intensive lifestyle intervention can prevent or delay the development of T2D in high‐risk populations. Translational research varies in hospitals, primary care, communities, the workplace, and other settings. Translational research is feasible but less effective. There have been no long‐term follow‐ups. The outcome of the studies was mainly weight changes. The Japan Diabetes Prevention Program (JDPP) is a trial to test the efficacy of a lifestyle intervention program, which carried out in a primary healthcare setting using existing resources. The Japan Diabetes Outcome Trial‐1 (J‐DOIT1) is a nationwide telephone‐delivered lifestyle intervention in a real‐world setting. This review will focus on the effectiveness of a diabetes prevention program (recruitment, target population, method of intervention, and evaluation) in the real world and insights from the JDPP and J‐DOIT1.
Association of DNMT3b gene variants with sporadic Parkinson's disease in a Chinese Han population
Authors: Chen Xiang , Xiao Yousheng , Wei Lei , Wu Yijuan , Lu Jianjun , Guo Wenyuan , Huang Shuxuan , Zhou Miaomiao , Mo Mingshu , Li Zhe , Cen Luan , Li Shaomin , Yang Chaohao , Wu Zhuohua , Hu Sophie , Pei Zhong , Yang XinLing , Qu Shaogang , Xu Pingyi 
Published: October 2017

AbstractBackgroundParkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Epigenetic modifications, specifically DNA methylation, have been implicated in the development of this disease. Genetic variants of DNA methyltransferase 3b (DNMT3b), one of the most important DNA methyltransferases, were shown to be associated with PD in a Brazilian population. However, it is unclear whether genetic variants of DNMT3b increase the risk of PD in the Chinese Han people. The present study aimed to investigate the association of the DNMT3b variants rs2424913, rs998382 and rs2424932 with PD in a Chinese Han population.MethodsWe studied 487 Chinese Han patients with sporadic PD and 485 healthy age‐, sex‐ and ethnicity‐matched controls. DNA was extracted from peripheral blood leukocytes and the individual genotypes were determined using the SNaPshot method.ResultsWe found that the rs2424932 and rs998382 variants were significantly associated with an increased risk of PD compared to the controls [rs2424932: odds ratio (OR) = 1.632, 95% confidence interval (CI) = 1.108–2.406, p = 0.013; rs998382: OR = 1.612, 95% CI = 1.103–2.382, p = 0.014]. Subgroup analysis suggested that female patients carrying the rs2424932 or rs998382 variants were more likely to develop PD than female controls (rs2424932: OR = 3.863, 95% CI = 2.004–7.445, p < 0.001; rs998382: OR = 3.679, 95% CI = 1.943–6.964, p < 0.001). Haplotype analysis indicated that the three variants comprised one block and that the Trs2424913‐Crs998382‐A rs2424932 haplotype was correlated with an increased risk of PD (p = 0.0046), especially for Chinese Han females (p < 0.0001).ConclusionsThe results of the present study strongly suggest that DNMT3b variants are associated with PD in the Chinese Han people, especially females.
Does Social Spending Improve Welfare in Low‐income and Middle‐income Countries?
Authors: Haile Fiseha , Niño‐Zarazúa Miguel 
Published: October 2017

AbstractOver the past two decades, there has been unprecedented attention to the promotion of human development via government spending in the social sectors as a conditio sine qua non for economic growth and improved aggregate welfare. Yet the existing evidence on the subject remains limited and contested. This paper contributes to the literature by examining the causal effect of government spending on the social sectors (health, education and social protection) on three measures of aggregate welfare: the Human Development Index, the Inequality‐adjusted Human Development Index and child mortality rates, using longitudinal data from 55 low‐income and middle‐income countries from 1990 to 2009. We find strong evidence to support the proposition that government social spending has played a significant role in improving aggregate welfare in the developing world. Our results are fairly robust to, inter alia, the method of estimation, the set of control variables and the use of alternative samples and instruments. © 2017 UNU‐WIDER. Journal of International Development published by John Wiley & Sons, Ltd.
Updating the research on the chemopreventive and therapeutic role of the peptide lunasin
Authors: Hsieh Chia‐Chien , Martínez‐Villaluenga Cristina , de Lumen Ben O , Hernández‐Ledesma Blanca 
Published: October 2017

AbstractChronic diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best strategy for the prevention of these disorders. Health promoting benefits beyond their nutritional effects have been described for multiple dietary compounds. Among these compounds, the peptide lunasin is considered as one of the most promising. Naturally present in soybean, lunasin has been extensively studied in the last two decades because of its potential against chronic diseases such as cancer, cardiovascular and immunological disorders. The purpose of this article is to summarise the evidence on the presence of lunasin in soybean and derived foods, and its bioavailability once it is orally ingested. The protective and therapeutic effects of this peptide against cancer, oxidative stress, inflammation, and high cholesterol levels as well as the molecular mechanisms of action involved in these effects are also described in this review. © 2017 Society of Chemical Industry
Effects of late‐stage nitrogen fertilizer application on the starch structure and cooking quality of rice
Authors: Cao XianMei , Sun HuiYan , Wang ChunGe , Ren XiaoJia , Liu HongFei , Zhang ZuJian 
Published: October 2017

AbstractBACKGROUNDWith the rapid development of modern agriculture, high‐quality rice production and consumption has become the current urgent demand for the development of rice production. In this paper, the effects of late‐stage nitrogen fertilizer application on rice quality were studied under the same genetic background. Wx near‐isogenic lines were used as test materials to study the starch composition, amylopectin structure and cooking quality of rice.RESULTSResults showed that rice amylose content and gel consistency significantly differed when different Wx genes were tranformed into waxy rice. The law of apparent amylose content in rice is Wxa > Wxin > Wxb > wx at the same nitrogen level, while the trend of gel consistency was opposite to that of apparent amylose content, presenting obvious characteristics of Indica and Japonica varieties. As the amount of fertilizer application increased, apparent amylose content increased, gel consistency decreased, breakdown and peak viscosities dropped and setback viscosity and peak time increased. Moreover, the cooking quality of rice significantly decreased with the use of nitrogen fertilizer, especially under low‐level nitrogen fertilizer application. Amylopectin structure varied significantly in different genotypes of the Wx gene, and the degree of branching was as follows: wx > Wxb > Wxin > Wxa. This result indicated that the closer to Indica rice, the fewer short chains of amylopectin. Starch crystallinity and swelling potential were negatively correlated with amylose content but significantly positively correlated with amylopectin branching degree, decreasing with the increase of late‐stage nitrogen fertilization.CONCLUSIONLate‐stage nitrogen fertilization reduced the cooking quality of rice by increasing amylose content and reducing amylopectin branching degree, which decreased starch crystallinity and aggravated pasting properties. Obviously, controlling late nitrogen application is essential to optimize rice quality. © 2017 Society of Chemical Industry