bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary, secondary and compensated hypogonadism: a novel risk stratification for infertile men
Authors: Ventimiglia E. , Ippolito S. , Capogrosso P. , Pederzoli F. , Cazzaniga W. , Boeri L. , Cavarretta I. , Alfano M. , Viganò P. , Montorsi F. , Salonia A. 
Published: April 2017

SummaryRecently, the cohort of men from the European Male Ageing Study has been stratified into different categories distinguishing primary, secondary and compensated hypogonadism. A similar classification has not yet been applied to the infertile population. We performed a cross‐sectional study enrolling 786 consecutive Caucasian‐European infertile men segregated into eugonadal [normal serum total testosterone (≥3.03 ng/mL) and normal luteinizing hormone (≤9.4 mU/mL)], secondary (low total testosterone, low/normal luteinizing hormone), primary (low total testosterone, elevated luteinizing hormone) and compensated hypogonadism (normal total testosterone; elevated luteinizing hormone). In this cross‐sectional study, logistic regression models tested the association between semen parameters, clinical characteristics and the defined gonadal status. Eugonadism, secondary, primary and compensated hypogonadism were found in 80, 15, 2, and 3% of men respectively. Secondary hypogonadal men were at highest risk for obesity [OR (95% CI): 3.48 (1.98–6.01)]. Primary hypogonadal men were those at highest risk for azoospermia [24.54 (6.39–161.39)] and testicular volume <15 mL [12.80 (3.40–83.26)]. Compensated had a similar profile to primary hypogonadal men, while their risk of azoospermia [5.31 (2.25–13.10)] and small testicular volume [8.04 (3.17–24.66)] was lower. The risk of small testicular volume [1.52 (1.01–2.33)] and azoospermia [1.76 (1.09–2.82)] was increased, although in a milder fashion, in secondary hypogonadal men as well. Overall, primary and compensated hypogonadism depicted the worst clinical picture in terms of impaired fertility. Although not specifically designed for infertile men, European Male Ageing Study categories might serve as a clinical stratification tool even in this setting.
Editorial: CT‐P13, a biosimilar of anti‐tumour necrosis factor‐alpha agent (infliximab), in inflammatory bowel diseases
Authors: Felwick R. , Cummings J. R. F. 
Published: April 2017

Linked ContentThis article is linked to Komaki et al papers. To view these articles visit https://doi.org/10.1111/apt.13990 and https://doi.org/10.1111/apt.14060.
Body mass index associates with white matter microstructure in bipolar depression
Authors: Mazza Elena , Poletti Sara , Bollettini Irene , Locatelli Clara , Falini Andrea , Colombo Cristina , Benedetti Francesco 
Published: April 2017

ObjectivesObesity has been reported in over 60% of bipolar disorder (BD) patients. It worsens the severity of illness, and influences cognition and functional outcomes. White matter (WM) abnormalities are one of the most consistently reported findings in neuroimaging studies of BD. We hypothesized that body mass index (BMI) could correlate with WM integrity in bipolar patients.MethodsWe evaluated BMI in a sample of 164 depressed patients affected by BD. We performed whole‐brain tract‐based spatial statistics with threshold‐free cluster enhancement for the diffusion tensor imaging (DTI) measures of WM integrity: fractional anisotropy; axial, radial, and mean diffusivity.ResultsWe observed that BMI was associated with DTI measures of WM integrity in several fiber tracts: anterior corona radiata, anterior thalamic radiation, inferior fronto‐occipital fasciculus and corpus callosum.ConclusionsThe association of BMI in key WM tracts that are crucial to mood regulation and neurocognitive functioning suggests that BMI might contribute to the pathophysiology of BD through a detrimental action on structural connectivity in critical cortico‐limbic networks.
Newsworthiness vs scientific impact: are the most highly cited urology papers the most widely disseminated in the media?
Authors: O'Connor Eabhann M. , Nason Gregory J. , O'Kelly Fardod , Manecksha Rustom P. , Loeb Stacy 
Published: April 2017

ObjectiveTo assess whether a correlation exists between newsworthiness (Altmetric score) and scientific impact markers, such as citation analysis, impact factors, and levels of evidence.MethodsThe top five most cited articles for the year 2014 and 2015 from the top 10 ranking urology journals (Scientific Impact Group) were identified. The top 50 articles each in 2014 and 2015 were identified from Altmetric support based on media activity (Media Impact Group). We determined the number of citations that these articles received in the scientific literature, and calculated correlations between citations with Altmetric scores.ResultsIn the Scientific Impact Group, the mean number of citations per article was 37.6, and the most highly cited articles were oncology guidelines. The mean Altmetric score in these articles was 14.8. There was a weak positive correlation between citations and Altmetric score (rs = 0.35, 95% confidence interval 0.16–0.52, P < 0.001). In the Media Impact Group, the mean Altmetric score was 121.1 and most widely shared articles all related to sexual medicine. In this group, the mean number of citations was 9.7 and there was a weak negative correlation between Altmetric score and citations (rs = −0.20, P = 0.046).ConclusionThe top articles based on Altmetric scores were not highly cited, suggesting that publications receiving the most media attention may not be the most scientifically rigorous, or that this audience places greater value on different subjects than the scientific community.
Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Authors: Panse Gauri , Cowper Shawn E. , Leffell David J. , Pulitzer Melissa , Ko Christine J. 
Published: April 2017

BackgroundWell‐differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5/6 (CK5/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms.MethodsWe reviewed 10 cases of cutaneous WDNETs (8 cases of metastatic disease and 2 presumed primary carcinoid tumors of the skin) and performed immunohistochemical stains for CK5/6 and p63 on all cases.ResultsAll 10 cases were negative with both CK5/6 and p63.ConclusionNegative staining for CK5/6 and p63 can be helpful to distinguish WDNETs from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low‐grade tumors may be the first sign of aggressive metastatic disease.
Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies
Authors: Agabalyan Natacha A. , Rosin Nicole L. , Rahmani Waleed , Biernaskie Jeff 
Published: April 2017

AbstractUnderstanding the cellular interactions and molecular signals underlying hair follicle (HF) regeneration may have significant implications for restorative therapies for skin disease that diminish hair growth, whilst also serving to provide fundamental insight into the mechanisms underlying adult tissue regeneration. One of the major, yet underappreciated, players in this process is the underlying HF mesenchyme. Here, we provide an overview of a mesenchymal progenitor pool referred to as hair follicle dermal stem cells (hfDSCs), discuss their potential functions within the skin and their relationship to skin‐derived precursors (SKPs), and consider unanswered questions about the function of these specialized fibroblasts. We contend that dermal stem cells provide an important reservoir of renewable dermal progenitors that may enable development of novel restorative therapies following hair loss, skin injury or disease.
Transforming growth factor β‐inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin‐induced mice skin fibrosis
Authors: Ide Maho , Jinnin Masatoshi , Tomizawa Yukiko , Wang Zhongzhi , Kajihara Ikko , Fukushima Satoshi , Hashizume Yoshinobu , Asano Yoshihide , Ihn Hironobu 
Published: April 2017

AbstractInhibition of transforming growth factor (TGF)‐β1 signalling may be one of the most reliable approaches to treat skin fibrosis of scleroderma. Although there have been many basic researches of TGF‐β blockade reagents, few of them were proved to have inhibitory effects on fibrosis both in vitro and in vivo. In this study, we randomly chose four commercially available low molecular weight compounds (Repsox, LY2109761, LY364947 and K02288) from TGF‐β1 inhibitor library, and compared their antifibrotic effects in vitro and in vivo. We demonstrated that Repsox has the most potent inhibitory effects on TGF‐β‐induced expression of CTGF and collagen of cultured normal dermal fibroblasts in vitro and their constitutive overexpression of scleroderma fibroblast in vitro. In addition, Repsox could attenuate skin fibrosis by bleomycin in vivo, via the downregulation of CTGF or collagen. Our results may facilitate clinical trial of Repsox against fibrotic diseases in future.
Physical activities impact sense of coherence among community‐dwelling older adults
Authors: Monma Takafumi , Takeda Fumi , Okura Tomohiro 
Published: April 2017

AbstractAimThe objective of the present study was to investigate bidirectional longitudinal relationships between sense of coherence (SOC) and physical activities (PA) among community‐dwelling older adults.MethodsSelf‐administered questionnaires were sent to 508 community‐dwelling adults aged 65–85 years who expressed their intention to participate in our surveys including cognitive function tests and physical performance tests. Of these, 427 people responded to the baseline survey, and 223 of them participated in the follow‐up survey 1 year later. Finally, the number of eligible respondents who had no missing values in all data was 179 (valid response rate: 35.2%). We used the 13‐item five‐point version of the Sense of Coherence Scale to assess SOC variables, and the Physical Activity Scale for the Elderly to assess PA variables. A structural equation modeling method was used to analyze bidirectional longitudinal relationships between SOC and PA. Cross‐lagged effects and synchronous effects models were applied to analyze these relationships. Demographic variables (age, sex, education, living arrangements, medical histories, employment status), cognitive function and physical performance were used as control variables.ResultsLeisure‐time PA had a cross‐lagged effect (β = 0.117, P < 0.05) and a synchronous effect (β = 0.217, P < 0.001) on SOC. In contrast, no significant effect of SOC on any type of PA was observed in either the cross‐lagged effects model or the synchronous effects model.ConclusionsLeisure‐time PA might contribute to enhancing SOC in community‐dwelling older adults. Geriatr Gerontol Int 2017; 17: 2208–2215.
Distance‐based Permutation of Inter‐Meal Differences as a Sensitive Test of Temporomandibular Joint Nociception in Rats
Authors: Umorin Mikhail , Kramer Phillip R. , Bellinger Larry L. 
Published: April 2017

We compare nonparametric permutation method using intra‐meal rate as endpoint with existing ANOVA method that uses average daily meal duration as an endpoint for detection of chronic pain in Sprague‐Dawley rats. Nociception following bilateral temporomandibular joint (TMJ) injection of high dose of Complete Freunds Adjuvant (CFA, 250 μg/50 μL per side) could be detected in young adult male Sprague‐Dawley rats using average daily meal durations as a measure of nociception for up to 19 days (Kramer, Kerins, Schneiderman & Bellinger, Physiology & Behavior, 99, 2010; 669) using ANOVA and multiple comparison range tests. In this study, we reanalyzed the data using a nonparametric permutation procedure based on absolute differences between intra‐meal feeding rate curves. In addition to that experiment, we injected bilaterally the TMJ of naive rats with either a low‐dose CFA (15 μg/50 μL per side, n = 6) or saline (50 μL of 0.9%, n = 4) and monitored the animals for 7 days. The permutation test of the intra‐meal feeding rate detected the presence of nociception in the high‐dose CFA treatment group for up to 40 days or twice as long as when using ANOVA on average daily meal durations. The permutation method also detected the low‐dose CFA‐induced nociception with ten times lower p‐values and for several days longer than ANOVA of changes in meal durations. CFA‐induced injury resulted in even reduction in intra‐meal feeding rate and lengthening of the meals in both high‐ and low‐dose CFA‐injected animals. The rate analysis also showed when the rats first started a meal they were experiencing the same level of nociception as at the end of the meal. This demonstrated that intra‐meal chewing itself did not alter the level of nociception. These results suggest that permutation tests based on differences in intra‐meal feeding rates can be used as a sensitive test to determine and study the temporal patterns of TMJ nociception.
Yoga and Cognitive‐behavioral Interventions to Reduce Stress in Incoming College Students: A Pilot Study
Authors: Park Crystal L. , Riley Kristen E. , Braun Tosca D. , Jung Ji Yeon , Suh Hyungyung G. , Pescatello Linda S. , Antoni Michael H. 
Published: April 2017

We examined the feasibility and differential efficacy of cognitive‐behavioral stress management (CBSM) and yoga for first‐year college students to reduce stress and improve mental and physical health. Thirty‐four incoming first‐year female students were assigned to 8 weeks of yoga, CBSM, or a wait‐list control. Assessments were made at baseline, end of intervention, and 4 months after intervention end. Both CBSM and yoga produced salutary changes in psychosocial and behavioral health as well as health‐related measures of physical function and activity relative to the control group. Stress‐management interventions are feasible and highly regarded by first‐year women and demonstrate promising effects.
Twenty‐four‐hour variations in blood glucose level in Japanese type 2 diabetes patients based on continuous glucose monitoring
Authors: Hajime Maiko , Okada Yosuke , Mori Hiroko , Otsuka Takashi , Kawaguchi Mayuko , Miyazaki Megumi , Kuno Fumi , Sugai Kei , Sonoda Satomi , Tanaka Kenichi , Kurozumi Akira , Narisawa Manabu , Torimoto Keiichi , Arao Tadashi , Tanaka Yoshiya 
Published: April 2017

AbstractAims/IntroductionHigh fluctuations in blood glucose are associated with various complications. The correlation between glycated hemoglobin (HbA1c) level and fluctuations in blood glucose level has not been studied in Japanese patients with type 2 diabetes. In the present study, blood glucose profile stratified by HbA1c level was evaluated by continuous glucose monitoring (CGM) in Japanese type 2 diabetes patients.Materials and MethodsOur retrospective study included 294 patients with type 2 diabetes who were divided by HbA1c level into five groups (≥6.0 to <7.0%, ≥7.0 to <8.0%, ≥8.0 to <9.0%, ≥9.0 to <10.0% and ≥10%). The correlation between HbA1c level and CGM data was analyzed. The primary end‐point was the difference in blood glucose fluctuations among the HbA1c groups.ResultsThe mean blood glucose level increased significantly with increasing HbA1c (Ptrend < 0.01). The standard deviation increased with increases in HbA1c (Ptrend < 0.01). The mean amplitude of glycemic excursions did not vary significantly with HbA1c. The levels of maximum blood glucose, minimum blood glucose, each preprandial blood glucose, each postprandial maximum blood glucose, range of increase in postprandial glucose from pre‐meal to after breakfast, the area under the blood concentration–time curve >180 mg/dL and percentage of the area under the blood concentration–time curve >180 mg/dL were higher with higher HbA1c. Mean glucose level and pre‐breakfast blood glucose level were significant and independent determinants of HbA1c.ConclusionsIn Japanese patients treated for type 2 diabetes, the mean amplitude of glycemic excursions did not correlate with HbA1c, making it difficult to assess blood glucose fluctuations using HbA1c. Parameters other than HbA1c are required to evaluate fluctuations in blood glucose level in patients receiving treatment for type 2 diabetes.
A Probabilistic Dynamic Material Flow Analysis Model for Chinese Urban Housing Stock
Authors: Cao Zhi , Shen Lei , Zhong Shuai , Liu Litao , Kong Hanxiao , Sun Yanzhi 
Published: April 2017

SummaryThe stock‐driven dynamic material flow analysis (MFA) model is one of the prevalent tools to investigate the evolution and related material metabolism of the building stock. There exists substantial uncertainty inherent to input parameters of the stock‐driven dynamic building stock MFA model, which has not been comprehensively evaluated yet. In this study, a probabilistic, stock‐driven dynamic MFA model is established and China's urban housing stock is selected as the empirical case. This probabilistic dynamic MFA model has the ability to depict the future evolution pathway of China's housing stock and capture uncertainties in its material stock, inflow, and outflow. By means of probabilistic methods, a detailed and transparent estimation of China's housing stock and its material metabolism behavior is presented. Under a scenario with a saturation level of the population, urbanization, and living space, the median value of the urban housing stock area, newly completed area, and demolished area would peak at around 49, 2.2, and 2.2 billion square meters, respectively. The corresponding material stock and flows are 79, 3.5, and 3.3 billion tonnes, respectively. Uncertainties regarding housing stock and its material stock and flows are non‐negligible. Relative uncertainties of the material stock and flows are above 50%. The uncertainty importance analysis demonstrates that the material intensity and the total population are major contributions to the uncertainty. Policy makers in the housing sector should consider the material efficiency as an essential policy to mitigate material flows of the urban building stock and to lower the risk of policy failures.
Role of autophagy in oocytogenesis, embryogenesis, implantation, and pathophysiology of pre‐eclampsia
Authors: Nakashima Akitoshi , Aoki Aiko , Kusabiraki Tae , Shima Tomoko , Yoshino Osamu , Cheng Shi‐Bin , Sharma Surendra , Saito Shigeru 
Published: April 2017

AbstractAutophagy is a well‐conserved mechanism in cells from yeast to mammals, and autophagy maintains homeostasis against stress. The role of autophagy was originally shown to be a mechanism of energy production under starvation. In fact, multiple lines of evidence reveal that autophagy has numerous functions, such as protection from stress, energy regulation, immune regulation, differentiation, proliferation, and cell death. In the field of reproduction, the role of autophagy in implantation, embryogenesis, placentation, and delivery has become clearer. In addition, recent study has elucidated that the placenta has the ability to protect extraplacental cells from virus infection by activating autophagy. During resent research into autophagy, several issues have occurred in the interpretation of the autophagy status. In this review, we discuss the relation between autophagy and reproductive events, and show the importance of autophagy for placentation and pre‐eclampsia.
Finding Bhaskar in all the wrong places? Causation, process, and structure in Bhaskar and Deleuze
Authors: Rutzou Timothy 
Published: April 2017

AbstractThis article examines the reception of Roy Bhaskar amongst some contemporary Deleuzians. It proceeds by rejecting the all too often predilection of opposing realism to ‘postmodernism’ or ‘post‐structuralism’ arguing instead for the need to bring one into dialogue with the other. To this end, the paper explores the resonances and points of departure between the work of Gilles Deleuze and Roy Bhaskar. In particular, it examines the language of causation, object‐oriented versus process‐oriented ontologies, as well as the charge by Deleuzians that Bhaskar is an essentialist. Through this engagement it attempts to develop and rethink explanation and causation in terms of a more chaotic ontology of machines, centered around the concept of structure, process, and production in an open, heterogeneous, and dynamic world. The end result is a more chaotic concept of realism.
Does my patient still have reflux when ppi therapy does not work?
Authors: Vaezi M. F. 
Published: April 2017

AbstractGastroesophageal reflux disease (GERD) is a common condition around the world. The management of this disease is less than satisfying given complexity of patient presentation and suboptimal diagnostic testing when employed for those poorly responsive to acid suppressive therapy. In this mini review, we discuss some new strategies employed for patients with suspected GERD to better understand disease pathophysiology. We compare the strategies and outline a clinically relevant approach in this difficult group of patients.
The effects of genome duplications in a community context
Authors: Segraves Kari A. 
Published: April 2017

ContentsSummary57I.Introduction57II.Impact of WGD on community context of polyploids: from the ground up59III.Predicted mechanisms by which WGD could affect community context59IV.Moving towards a predictive framework63V.Recurrent formation, geographic mosaics, and community context64VI.Alternative perspectives – impact of the appearance of polyploid plants in a community64VII.Sand, pebbles, and boulders66Acknowledgements66References66SummaryWhole‐genome duplication (WGD), or polyploidy, has important effects on the genotype and phenotype of plants, potentially altering ecological interactions with other organisms. Even though the connections between polyploidy and species interactions have been recognized for some time, we are only just beginning to test whetherWGDaffects community context. Here I review the sparse information on polyploidy and community context and then present a set of hypotheses for future work. Thus far, community‐level studies of polyploids suggest an array of outcomes, from no changes in community context to shifts in the abundance and composition of interacting species. I propose a number of mechanisms for howWGDcould alter community context and how the emergence of polyploids in populations could also alter the community context of parental diploids and other plant species. Resolving how and when these changes are expected to occur will require a deeper understanding of the connections amongWGD, phenotypic changes, and the direct and indirect effects of species interactions.