bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site
Authors: Ihedioha Olivia C. , Marcarian Haley Q. , Sivakoses Anutr , Beverley Stephen M. , McMahon-Pratt Diane , Bothwell Alfred L. M. 
Published: October 2024

BackgroundHost-related factors highly regulate the increased circulation of neutrophils during Leishmania infection. Platelet-derived Dickkopf-1 (DKK1) is established as a high-affinity ligand to LRP6. Recently, we demonstrated that DKK1 upregulates leukocyte-platelet aggregation, infiltration of neutrophils to the draining lymph node and Th2 differentiation during Leishmania infection, suggesting the potential involvement of the DKK1-LRP6 signalling pathway in neutrophil migration in infectious diseases.ResultsIn this study, we further explored the potential role of DKK1-LRP6 signalling in the migration and longevity of activated neutrophils in the infection site using BALB/c mice with PMNs deficient in LRP6 (LRP6NKO) or BALB/c mice deficient in both PMN LRP6 and platelet DKK1 (LRP6NKO DKK1PKO). Relative to the infected wild-type BALB/c mice, reduced neutrophil activation at the infection site of LRP6NKO or LRP6NKO DKK1PKO mice was noted. The neutrophils obtained from either infected LRP6NKO or LRP6NKO DKK1PKO mice additionally showed a high level of apoptosis. Notably, the level of LRP6 expressing neutrophils was elevated in infected BALB/c mice. Relative to infected BALB/c mice, a significant reduction in parasite load was observed in both LRP6NKO and LRP6NKO DKK1PKO infected mice. Notably, DKK1 levels were comparable in the LRP6NKO and BALB/c mice in response to infection, indicating that PMN activation is the major pathway for DKK1 in promoting parasitemia. Parasite-specific components also play a crucial role in modulating neutrophil circulation in Leishmania disease. Thus, we further determine the contribution of Leishmania membrane components in the migration of neutrophils to the infection site using null mutants deficient in LPG synthesis (Δlpg1-) or lacking all ether phospholipids (plasmalogens, LPG, and GIPLs) synthesis (Δads1-). Relative to the WT controls, Δads1- parasite-infected mice showed a sustained decrease in neutrophils and neutrophil-platelet aggregates (for at least 14 days PI), while neutrophils returned to normal in Δlpg1- parasite-infected mice after day 3 PI.ConclusionOur results suggest that DKK1 signalling and Leishmania pathogen-associated molecular patterns appear to regulate the migration and sustenance of viable activated neutrophils in the infection site resulting in chronic type 2 cell-mediated inflammation.
Investigation of immunosuppressive treatment compliance, dyspnea, anxiety, and depression levels in lung transplant recipients: online interview
Authors: Bulbuloglu Semra , Sayim Halil Ibrahim 
Published: October 2024

IntroductionFollowing lung transplantation (LTx), it is important for recipients to comply with immunosuppressive treatment and cope with related problems. In the post-LTx period, the course of dyspnea and psychological problems it causes in case of progression are not known. Depression and anxiety may develop in recipients after LTx. However, the relationship between this situation and treatment compliance and dyspnea is uncertain.ObjectiveThe aim of this study was to investigate dyspnea, anxiety, and depression levels of recipients following LTx and their immunosuppressive treatment compliance.MethodThe study was planned as a descriptive, correlational, and cross-sectional study. Data were collected on various social media platforms via an online interview, and 65 LTx recipients were included in the sample (n = 65). A Participant Information Form, the Modified Borg Scale, the Beck Anxiety Inventory, the Beck Depression Inventory, and the Immunosuppressive Drug Compliance Scale were employed to collect data. The collected data were analyzed using descriptive statistics, the Mann–Whitney U test, and the Kruskal-Wallis test.ResultsThe mean age of the participants was found to be 52.60 ± 9.44 years, and 56.9% were male. Forty percent of the participants were dependent on oxygen support, and 32.2% had hypertension. Their dyspnea levels were mild, anxiety levels were moderate, depression levels were high, and immunosuppressive treatment compliance levels were slightly above-average. According to the correlation analysis results, dyspnea was associated with anxiety and depression (p &lt; 0.05). As depression increased, immunosuppressive treatment compliance decreased, and the correlation between the two variables was statistically significant (p &lt; 0.05).ConclusionIn this study, as the severity of dyspnea experienced by LTRs increased, the severity of their anxiety and depression also increased. Additionally, there was an inverse correlation between depression and immunosuppressive treatment compliance. LTRs demonstrated insufficient adherence to their immunosuppressive drug regimens, which is very significant in terms of graft survivability. These results suggest that LTRs should be closely monitored at home.
Functional excitation-inhibition ratio for social anxiety analysis and severity assessment
Authors: Chu Linh Ha , Chau Chi Que , Kamel Nidal , Thanh Huong Ha Thi , Yahya Norashikin 
Published: October 2024

IntroductionSocial anxiety disorder (SAD) is a prevalent psychiatric condition characterized by an intense fear of and avoidance of social situations. Traditional assessment methods for SAD primarily rely on subjective self-report questionnaires and clinical interviews, which can be prone to biases and inaccuracies. This study aims to explore the functional excitation-inhibition (fEI) ratio derived from EEG data as a potential objective biomarker for assessing SAD severity. MethodsResting-state EEG data were collected from 20 control subjects and 60 individuals with varying degrees of SAD severity (mild, moderate, and severe). The fEI ratio was estimated across different EEG bands and analyzed, focusing on differences between control subjects and SAD groups. ResultsSignificantly higher fEI ratios were observed in the alpha and low beta EEG bands in individuals with SAD compared to controls, especially within the prefrontal cortex. Additionally, a positive correlation was found between the fEI ratio and the severity of social anxiety symptoms across SAD severity levels. DiscussionThe findings indicate that the fEI ratio in the alpha and low beta bands may serve as a promising biomarker for assessing SAD severity. These results contribute to a deeper understanding of the neural mechanisms underlying social anxiety, offering a potentially more objective approach to SAD assessment compared to traditional methods.
Nurses’ strategies for coping with stress in the face of the influx of war refugees from Ukraine to Poland
Authors: Kowalczuk Krystyna , Tomaszewska Katarzyna , Szpakow Andriej , Krajewska-Kułak Elżbieta , Sobolewski Marek , Hermanowicz Justyna Magdalena 
Published: October 2024

IntroductionRussian military’s incursion into Ukraine sparked the largest refugee crisis in Europe since World War II. As Ukraine’s neighboring country, Poland became the primary destination for these refugees. Ukrainians staying in Poland under the EU’s Temporary Protection Directive receive humanitarian support similarly to asylum seekers, but the legal pathways, length of stay and integration processes differ significantly as the Directive provides for more immediate, collective protection without the complexity of individual asylum applications. The influx of war refugees generates extremely complex situations that health personnel, especially nurses, must face on a daily basis.AimIdentify whether and to what extent the emergence of a large number of patients with war-related experiences constituted a source of stress for nurses, and how Polish nurses coped with this issue.Materials and methodA cross-sectional study was conducted in December 2022 in Białystok, Poland. It included 473 certified nurses working in hospitals affiliated with the District Chamber of Nurses in Białystok. Perceived Stress Scale (PSS-10) questionnaire and Mini-COPE inventory (Polish version of Carver’a BriefCOPE inventory were used in the study.ResultsThe average stress level among nurses was moderate, with nearly equal proportions of nurses experiencing low, medium, and high stress levels. Nurses who had contact with refugees in the last six months and/or helped them, did not present an increased level of stress - on the contrary, this level was lower. Nurses who helped refugees at work more often used a planning strategy in stressful situations, and less frequently reacted to stress using humour, religion, denial or venting.ConclusionsThe greater workload and more frequent contacts between Polish nurses and Ukrainian war refugees were a factor increasing work fatigue, but, paradoxically, at the same time reducing the level of stress in a situation giving the feeling of a duty well fulfilled. Empowering nurses through greater autonomy and fostering supportive work environments, especially in crisis situations like the care of war refugees has a positive impact on coping with stress.
Determinants of unsuccessful tuberculosis treatment outcome in Southwest Ethiopia regional state public hospitals, 2022: a multi-center case control study
Authors: Berihe Hiluf Solomon , Abera Abebe , Bahiru Mesfin , Kassie Birhanu 
Published: October 2024

BackgroundTuberculosis is the major cause of morbidity, and it is one of the top ten causes of death globally. In Africa, the overall pooled estimate of unsuccessful tuberculosis treatment outcome was reported to be 21.1%, which is above the World Health Organization defined threshold of 15%. Unsuccessful treatment outcomes result in drug resistance, prolonged periods of infection, and increased morbidity and mortality. Therefore, this study aimed to assess determinants of unsuccessful treatment outcomes among tuberculosis patients in Southwest Ethiopia regional state public hospitals, in 2022.MethodA retrospective unmatched case–control study was employed by recruiting 570 study units (190 cases and 380 controls) in three randomly selected public hospitals from 1 August 2022 to 21 August 2022. Data were collected by using a data extraction checklist adapted from tuberculosis registration logbook. Bivariate and multivariate logistic regression models were employed. A predictor variable with a p-value of less than 0.05 in the multivariate logistic regression model was taken as statistically significant. The odds ratio and 95% confidence level were used to measure the strength of the association.ResultA total of 561 records (187 cases and 374 controls) were included from tuberculosis registers. In this study, the factors independently associated with unsuccessful tuberculosis treatment outcome were older age (AOR = 1.68, 95% CI: 1.142, 2.472), rural residence (AOR = 1.548, 95% CI: 1.055, 2.272), retreatment category (AOR = 2.12, 95% CI: 1.339, 3.357), underweight (BMI &lt; 18.5 kg/m2) (AOR = 1.952, 95% CI: 1.240, 3.071), being HIV positive (AOR = 2.144, 95% CI: 1.372, 3.349) and having no treatment adherence support (AOR = 2.016, 95% CI: 1.270, 3.201).Conclusion and recommendationIn this study, socio-demographic, clinical, and treatment-related factors contributed to the risk of unsuccessful treatment outcomes. Targeted interventions should be taken into consideration to diminish poor tuberculosis treatment outcomes among high-risk groups throughout the whole tuberculosis treatment course.
Educational needs and its associated factors among patients with ankylosing spondylitis in China: a multicenter cross-sectional study
Authors: Song Yuqing , Shen Weiping , Deng Xue , Xing Lu , Tang Yuping , Liu Mei , Jiang Qiaolin , Chen Yanling , He Benyi , Wang Li , Tang Fangmei , Wu Jianmei 
Published: October 2024

ObjectivePatient education is an important part of ankylosing spondylitis (AS) management. Effective patient education should be targeted at specific priorities and needs of the patients. However, the educational needs of patients with AS in China have not been systematically explored. The purpose of this study was to assess the level of educational needs and analyze associated factors in patients with AS in China.MethodsThis multicenter cross-sectional study was conducted at five hospitals in China. The Chinese version of the Educational Needs Assessment Tool (ENAT) was used to measure educational needs. Disease activity and physical function were assessed using the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Multiple linear regression analysis was used to identify the predictors of educational needs.ResultsThis study included 163 patients with AS. The mean ENAT score was 86.25 (31.64). Patients wanted to know more about the arthritis process, self-help measures, and treatments. Multiple linear regression analysis indicated that younger age, being female, higher disease activity, and no family history of AS (p &lt; 0.05) were positive predictors of educational needs.ConclusionPatients with AS in China have considerable educational needs, particularly in the domains of arthritis, self-help, and treatment. Female patients and patients with younger age, higher disease activity, and no family history may have higher educational needs. These factors should be considered when conducting need-based patient education programs. Healthcare professionals should integrate need-based patient education into rheumatology care in the future.
Comparative study on slaughter performance, meat quality, and rumen microbiota of Hainan Dong goat and its hybrid with Nubian goat
Authors: Shi Huiyu , Zhang Naifeng , Tu Yan , Yun Yanhong , Diao Qiyu , Ma Tao 
Published: October 2024

IntroductionThe Hainan Dong goat (DG) is a local meat breed widely raised in Hainan, China because of its good adaptability to local hot and humid weather. However, the growth rate of these DG is much slower than that of commercialised breeds improved in European countries, resulting in poor carcase characteristics, including smaller slaughter weight and carcase weight, which have become increasingly prominent. In recent decades, Nubian goats have been continuously imported into China to improve the production performance of local breeds.MethodsIn this study, the effects of breed on growth performance, carcase and meat quality, and ruminal microbiota were analysed in 40 goats, including 20 DGs and 20 hybrid F3 offspring generated by crossing the DG and Nubian hybrids (NH). All the goats were averagely aged 90 days and weighed at 11  ±  1.34  kg. They were assigned to two treatments, with three replicates per treatment. The two groups were fed the same diet for 90 days before slaughter.ResultsThe results showed that the average daily gain, F/G ratio, slaughter weight, and carcase weight of the NH group were higher than those of the DG group (p &lt; 0.05). However, tube circumference, meat-to-bone ratio, and eye muscle pH were lower in the NH group than in the DG group (p &lt; 0.05). The NH group showed a smaller fibre crosssectional area and fibre diameter, but a larger fibre density than the DG group (p &lt; 0.05). Bacteroidetes and Firmicutes were the most dominant phyla in the two groups; however, the two breeds had different ruminal microbial communities.DiscussionIn the present study, the differences in growth performance between two groups of goats under the same feeding environment and feed conditions were compared. The correlation between feed sources and rumen flora has been demonstrated, and the results of this study show that the same diet has similar effects on rumen microorganisms, which in turn have related effects on growth and production performance.ConclusionIn summary, hybrids can improve the growth and slaughter performance of local breeds, which may be related to changes in the rumen microorganisms. This study revealed that crossbreeding of Nubian goats with Dong goats has the potential to be used in a wide range of applications owing to its effectiveness in increasing production efficiency.
Case report: use of pleural dialysis as an alternate means of renal replacement therapy in three cats
Authors: Vernier Mara E. , Fick Meghan E. , Johnson Tyler E. , Ueda Yu , Vigani Alessio 
Published: October 2024

ObjectiveThe objective of this case series is to describe the indications, methodology, and short-term outcomes of three cats with severe azotemia managed with pleural dialysis.Case summaryThree cats were presented separately to the emergency room (ER) on referral for severe azotemia of varying etiologies. Despite aggressive medical and/or surgical management, none of the cats showed improvement in their blood urea nitrogen (BUN) or creatinine values. Renal replacement therapy was recommended, but for varying reasons, the patients were unable to undergo a traditional extracorporeal method, such as intermittent hemodialysis (IDH). Instead, pleural dialysis was performed, and all three cats showed improvement in their renal values during and after their treatment. No significant complications were documented as a result of pleural dialysis. Two of the three cats were discharged from the hospital and the third cat was humanely euthanized due to poor prognosis.New or unique information providedPleural dialysis is a novel therapeutic procedure that is not documented in veterinary or human literature. This method of renal replacement therapy was well-tolerated and had no reported complications. Careful case selection and risk-benefit analysis should be considered before attempting this procedure. Further studies are necessary to further define the utility of this therapeutic intervention, evaluate the incidence of complications, and determine long term outcomes following the procedure.
Clinical and Humanistic Burden of IgA Nephropathy in Adult Patients
Authors: Tang Sydney C.W. , Chen Wei , Aldworth Carolina , Thomas George Aneesh , Kattlun Julia , Rovira Tomas Gisela , Kroes Michel , Roccatello Dario , Przybysz Raymond , Smeets Serge , Golden Keisha , Garratt-Wheeldon Jade , Chatterton Emma , de Courcy Jonathan , Lafayette Richard 
Published: October 2024

Key Points

IgA nephropathy (IgAN) exerts a significant humanistic burden on patients.Quality of life is impaired in patients with IgAN.Progression of disease in IgAN, especially proteinuria and GFR loss, are associated with the burden of disease.

Background
IgA nephropathy (IgAN) is a chronic, progressive kidney disease in which proteinuria, reduced eGFR, pain, and fatigue are common. How symptoms interact and affect patient quality of life (QoL) in real-world practice is poorly studied. This study investigated how patient and physician symptom perceptions differ and how proteinuria and eGFR correlate with pain, fatigue, and QoL in adult patients with IgAN.

Methods
Data were drawn from the Adelphi IgAN Disease Specific Program, a cross-sectional survey of physicians and their biopsy confirmed patients with IgAN in China, France, Germany, Italy, Spain, the United Kingdom, the United States, and Japan from June to October 2021. Physicians provided demographics and clinical characteristics, including pain and fatigue severity. The same patients completed a self-completion form containing questions on symptom severity, the EQ-5D-5L, Kidney Disease QoL, and Work Productivity and Activity Impairment questionnaires. Symptom scores were grouped by severity, and patients were grouped by proteinuria and eGFR. Analysis of variance, chi-squared, or Fisher exact tests were performed as appropriate and Dunn multiple comparisons with Bonferroni adjustment for pair-wise comparisons.

Results
Overall, 1515 patients were included (mean [SD] age: 43 [15] years, 60% [n=903] male, 70% [n=1020/1459] diagnosed >1 year ago). Pain was reported by 46% (n=374) of physicians and 47% (n=384) of patients and fatigue by 65% (n=530) of physicians and 76% (n=620) of patients. Both pain and fatigue increased with increased proteinuria and reduced eGFR (all P < 0.001). Finally, patients with increased proteinuria and reduced eGFR experienced worse (P < 0.05) QoL and work productivity across all measures (except work absenteeism).

Conclusions
Patients with higher proteinuria and lower eGFR face higher symptom burden and reduced QoL compared to their counterparts. Physicians underestimated fatigue levels faced by patients. To improve QoL, more effective treatments are needed to prevent high proteinuria and preserve eGFR.
Специальная военная операция в российских музеях: обзор экспозиционно-выставочных проектов (2022-2023 гг.)
Authors: Зотова Т.А. , Окороков А.В. 
Published: October 2024

В течение 2022–2023 гг. российскими музеями был подготовлен ряд выставок и экспозиций, рассказывающих о трагедии мирного населения Донбасса, о возрождении нацисткой идеологии на Украине и о подвигах героев СВО. Обзор этих актуальных музейных практик, представленный в статье, включает несколько направлений: проекты военно-исторических музеев; выставки, подготовленные в центральных, региональных и местных музеях; выставочные проекты общественных движений и фондов.
During 2022–2023 Russian museums prepared a number of exhibitions on the tragedy of the civilian population of Donbass, the revival of Nazi ideology in Ukraine, and the exploits of the heroes of the Special military operation. An overview of these current museum practices is presented in the article. This includes several areas: projects of military history museums; exhibitions prepared in central, regional and local museums; exhibition projects of social movements and foundations.
ENCENAÇÕES DA ESCRITURA
Authors: Fagundes Monica Genelhu , Vasconcelos Viviane , Lentina Alda Maria 
Published: October 2024

Artes poéticas, cenas de escrita, metáforas do fazer poético: essas e outras encenações da escritura estão contempladas pelo Dossiê de Literatura do Volume 24-2 da Diadorim: revista de estudos linguísticos e literários.
From monuments to living heritage. Revisiting the Venice Charter in the conservation of younger industrial heritage
Authors: Klysner Steffensen Alberte 
Published: October 2024

The Venice Charter of 1964 has been the benchmark for tenets governing architectural conservation and set forth pivotal principles that shaped conservation practices for decades. However, conceived during a time when heritage was primarily associated with physical monuments, the landscape of cultural heritage has transformed significantly since then, encompassing immaterial aspects, democratisation of heritage values, and diverse sustainability considerations.This research aims at exploring the strengths, limitations, and adaptability of the Venice Charter in light of evolving perspectives on heritage. The paper delves into the charter's historical context, asking whether it remains a guiding beacon or a potential hindrance. A key focus of the research is the examination of obstacles associated with the conservation of younger heritage in the face of contemporary challenges posed by sustainability imperatives. The inherent complexities of managing heritage structures marked by ongoing developmental histories and changes are explored with an example of industrial heritage dealing with the concept of ‘living heritage’. In the context of a future where resource responsibility and reuse are paramount matters, firm definitions of original substance as defined in the Venice Charter, as well as a static perception of conservation, may pose challenges, particularly for unintentional monuments situated in complex environments or marked by evolving narratives through time. Marking the 60th anniversary of the Venice Charter, this research sheds light on the charter’s legacy and its validity in the contemporary landscape of heritage protection as well as the future role of the monuments in our ever-changing societal context.