bluuebunny/crossref_metadata_2025_split huggingface dataset:
A compact fiber‐optic probe‐based singlet oxygen luminescence detection system
Authors: Gemmell Nathan R. , McCarthy Aongus , Kim Michele M. , Veilleux Israel , Zhu Timothy C. , Buller Gerald S. , Wilson Brian C. , Hadfield Robert H. 
Published: July 2016

This paper presents a novel compact fiberoptic based singlet oxygen near‐infrared luminescence probe coupled to an InGaAs/InP single photon avalanche diode (SPAD) detector. Patterned time gating of the single‐photon detector is used to limit unwanted dark counts and eliminate the strong photosensitizer luminescence background. Singlet oxygen luminescence detection at 1270 nm is confirmed through spectral filtering and lifetime fitting for Rose Bengal in water, and Photofrin in methanol as model photosensitizers. The overall performance, measured by the signal‐to‐noise ratio, improves by a factor of 50 over a previous system that used a fiberoptic‐coupled superconducting nanowire single‐photon detector. The effect of adding light scattering to the photosensitizer is also examined as a first step towards applications in tissue in vivo.
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Assessing the uncertainty of CESM‐LE in simulating the trends of mean and extreme temperature and precipitation over China
Authors: Li Juan , Zhu Zhiwei , Dong Wenjie 
Published: July 2016

ABSTRACTClimate change affects mean and extreme temperature and precipitation, increasing the risk of related disasters. Assessing the performance of current models in simulating these aspects is therefore crucial to future projection and policymaking. Based on a large ensemble (LE; 30 members) of the Community Earth System Model (CESM‐LE), this study seeks to answer the following two questions: (1) Are the simulated trends of mean and extreme temperature and precipitation over China consistent with observations? (2) What is the range of model uncertainty due to internal variability? The results show that CESM‐LE can capture the trends of observed annul mean temperature and extremely low temperature days (ELD) over 16–26% of China, but has difficulty in reproducing the observed trends in extremely high temperature days (EHD). For precipitation, CESM‐LE demonstrates similar capability in reproducing the observed trends in annual mean precipitation and extreme precipitation days (EPD). For consecutive dry days (CDD), the decreasing trends over part of northwestern China can be captured, but the increasing trends over northern China cannot be reproduced by CESM‐LE. Regarding the uncertainty of the model resulting from natural internal variability, because all 30 ensemble members of CESM use the same model and external forcing, CESM‐LE's spread (uncertainty) is mainly due to internal variability. Larger uncertainty in simulated trends is found over northern China and the Tibetan Plateau for annual mean temperature, over northeastern China and the Huang‐Huai region for ELD, and over the Tibetan Plateau for EHD. The trends in annual mean precipitation show uniform uncertainty over nearly all of China, except for the northwest. Larger uncertainty trends appear over southern and northwestern China for EPD, and over the Tibetan Plateau and northern China for CDD.
High efficiency coronary MR angiography with nonrigid cardiac motion correction
Authors: Pang Jianing , Chen Yuhua , Fan Zhaoyang , Nguyen Christopher , Yang Qi , Xie Yibin , Li Debiao 
Published: July 2016

PurposeTo improve the coronary visualization quality of four‐dimensional (4D) coronary MR angiography (MRA) through cardiac motion correction and iterative reconstruction.MethodsA contrast‐enhanced, spoiled gradient echo sequence with 3D radial trajectory and self‐gating was used for 4D coronary MRA data acquisition at 3 Tesla. A whole‐heart 16‐phase cine series was reconstructed with respiratory motion correction. Nonrigid registration was performed between the identified quiescent phases and a reference. The motion information of all included phases was then used along with the corresponding k‐space data to iteratively reconstruct the final image. Healthy volunteer studies (N = 13) were conducted to compare the proposed method with the conventional strategy, which accepts data from a single, contiguous window out of the original 16‐phase data. Apparent signal‐to‐noise ratio (aSNR) and coronary sharpness were used as the image quality metrics.ResultsThe proposed method significantly improved aSNR (11.89 ± 3.76 to 13.97 ± 5.21; P = 0.005) and scan efficiency (18.8% ± 6.0% to 40.9% ± 9.7%; P < 0.001), compared with the conventional strategy. Sharpness of left main (P = 0.002), proximal (P = 0.04), and middle (P = 0.02) right coronary artery, and proximal left anterior descending (P = 0.04) was also significantly improved.ConclusionThe proposed cardiac motion‐corrected reconstruction significantly improved the achievable quality of coronary visualization from 4D coronary MRA. Magn Reson Med 76:1345–1353, 2016. © 2016 International Society for Magnetic Resonance in Medicine
Test–retest analysis of multiple 31P magnetization exchange pathways using asymmetric adiabatic inversion
Authors: Pouymayou Bertrand , Buehler Tania , Kreis Roland , Boesch Chris 
Published: July 2016

PurposeA 31P‐MR inversion transfer (IT) method with a short adiabatic inversion pulse is proposed and its test–retest reliability was evaluated for two spectral fitting strategies.MethodsAssessment in a test–retest design (3 Tesla, vastus muscles, 12 healthy volunteers, 14 inversion times, 22 ms asymmetric adiabatic inversion pulse, adiabatic excitation); spectral fitting in Fitting Tool for Interrelated Arrays of Datasets (FitAID) and Java Magnetic Resonance User Interface (jMRUI); least squares solution of the Bloch‐McConnell‐Solomon matrix formalism including all 14 measured time‐points with equal weighting.ResultsThe cohort averages of k[PCr→γ‐ATP] (phosphocreatine, PCr; adenosine triphosphate, ATP) are 0.246 ± 0.050s−1 versus 0.254 ± 0.050s−1, and k[Pi→γ‐ATP] 0.086 ± 0.033s−1 versus 0.066 ± 0.034s−1 (average ± standard deviation, jMRUI versus FitAID). Coefficients of variation of the differences between test and retest are lowest (9.5%) for k[PCr→γ‐ATP] fitted in FitAID, larger (15.2%) for the fit in jMRUI, and considerably larger for k[Pi→γ‐ATP] fitted in FitAID (43.4%) or jMRUI (47.9%). The beginning of the IT effect can be observed with magnetizations above 92% for noninverted lines while inversion of the ATP resonances is better than −72%.ConclusionThe performance of the asymmetric adiabatic pulse allows an accurate observation of IT effects even in the early phase; the least squares fit of the Bloch‐McConnell‐Solomon matrix formalism is robust; and the type of spectral fitting can influence the results significantly. Magn Reson Med 78:33–39, 2017. © 2016 International Society for Magnetic Resonance in Medicine
In Brief: Mitophagy: mechanisms and role in human disease
Authors: Springer Maya Z , Macleod Kay F 
Published: July 2016

AbstractMitophagy is a selective form of macro‐autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role in cellular homeostasis by eliminating dysfunctional mitochondria and reducing mitochondrial mass as an adaptive response to stress. Cells execute mitophagy through several non‐redundant mechanisms, including the PINK1/Parkin partnership, which modulates turnover of depolarized mitochondria, and stress‐induced BNIP3, NIX, and FUNDC1 molecular adaptors, which interact directly with LC3 to promote mitophagy. These pathways are deregulated in human diseases, including cancer, neurodegeneration, metabolic disorders, muscle atrophy, ageing, and inflammation, reflecting the importance of mitophagy as a cellular housekeeping function. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Rookies and seasoned recruits: How experience in different levels, firms, and industries shapes strategic renewal in top management
Authors: Williams Charles , Chen Pao‐Lien , Agarwal Rajshree 
Published: July 2016

Research summary: This study explores the effect of knowledge integration on strategic renewal. In particular, it examines how executives from different levels and sources influence renewal when added to top management teams (TMT). In contrast to prior work, the study hypothesizes and finds that new outside rookies—those new to top management and the firm—are associated with higher firm growth than other types of executives. We also find that seasoned outsiders—those with prior TMT experience outside the focal industry—contribute to growth only when the existing TMT has a long tenure. The results suggest that the ability of the TMT to integrate new members varies by executive type and has an important effect on incremental strategic renewal.Managerial summary: Conventional wisdom holds that firms are better off hiring those who can demonstrate prior experience and skill in tasks as close as possible to the job. In the realm of the top management team (TMT), however, we find that many firms benefit from hiring rookies from other firms who are new to the top management team level. These candidates bring useful knowledge of the operations of competitors and other firms, and they are easier to socialize and integrate with the existing team. While more experienced senior leaders may bring valuable strategic knowledge, this study suggests that only top management teams with long shared experience can weather the disruption that they cause to realize the potential benefits. Copyright © 2016 John Wiley & Sons, Ltd.
Generalised rely-guarantee concurrency: an algebraic foundation
Authors: Hayes Ian J. 
Published: July 2016

Abstract
The rely-guarantee technique allows one to reason compositionally about concurrent programs. To handle interference the technique makes use of rely and guarantee conditions, both of which are binary relations on states. A rely condition is an assumption that the environment performs only atomic steps satisfying the rely relation and a guarantee is a commitment that every atomic step the program makes satisfies the guarantee relation. In order to investigate rely-guarantee reasoning more generally, in this paper we allow interference to be represented by a process rather than a relation and hence derive more general rely-guarantee laws. The paper makes use of a weak conjunction operator between processes, which generalises a guarantee relation to a guarantee process, and introduces a rely quotient operator, which generalises a rely relation to a process. The paper focuses on the algebraic properties of the general rely-guarantee theory. The Jones-style rely-guarantee theory can be interpreted as a model of the general algebraic theory and hence the general laws presented here hold for that theory.
Surgical Indications of Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Body/Tail Cancer
Authors: Sugiura Teiichi , Okamura Yukiyasu , Ito Takaaki , Yamamoto Yusuke , Uesaka Katsuhiko 
Published: July 2016

AbstractBackgroundThe survival impact of distal pancreatectomy (DP) with celiac axis resection for locally advanced pancreatic body/tail cancer remains unclear.MethodsA total of 16 patients underwent DP with celiac axis resection, while 76 underwent standard DP for pancreatic body/tail cancer. The indications for DP with celiac axis resection included: (a) tumor invasion of either the celiac axis or common hepatic artery or both [CA/CHA (+)] and (b) tumor invasion of the root of the splenic artery, which is difficult to dissect without securing an adequate surgical margin [CA/CHA (−)].ResultsDP with celiac axis resection presented longer operative time and greater amount of blood loss than DP. The median survival time was 17.5 months in the DP with celiac axis resection group and 43.1 months in the DP group (p = 0.040). Among the patients who underwent DP with celiac axis resection, the median survival time was 35.1 months in the CA/CHA (−) group and 13.2 months in the CA/CHA (+) group (p = 0.001). Comparing the patients undergoing standard DP and DP with celiac axis resection with a CA/CHA (−) status, there were no significant differences in either disease‐free or overall survival times. The CA19‐9 value, CA/CHA (+) status, and microscopic venous infiltration were revealed independent significant prognostic factors.ConclusionsDP with celiac axis resection should therefore be indicated in patients with a CA/CHA (−) status. However, it is difficult to justify the use of DP with celiac axis resection in patients with CA/CHA (+) status due to the poor survival.
The Current State and Path Forward For Enterprise Image Viewing: HIMSS-SIIM Collaborative White Paper
Authors: Roth Christopher J. , Lannum Louis M. , Dennison Donald K. , Towbin Alexander J. 
Published: July 2016

AbstractClinical specialties have widely varied needs for diagnostic image interpretation, and clinical image and video image consumption. Enterprise viewers are being deployed as part of electronic health record implementations to present the broad spectrum of clinical imaging and multimedia content created in routine medical practice today. This white paper will describe the enterprise viewer use cases, drivers of recent growth, technical considerations, functionality differences between enterprise and specialty viewers, and likely future states. This white paper is aimed at CMIOs and CIOs interested in optimizing the image-enablement of their electronic health record or those who may be struggling with the many clinical image viewers their enterprises may employ today.
The second report of a new hypomyelinating disease due to a defect in the VPS11 gene discloses a massive lysosomal involvement
Authors: Hörtnagel Konstanze , Krägeloh‐Mann Inge , Bornemann Antje , Döcker Miriam , Biskup Saskia , Mayrhofer Heidi , Battke Florian , du Bois Gabriele , Harzer Klaus 
Published: July 2016

AbstractVesicular protein sorting‐associated proteins (VPS, including VPS11) are indispensable in the endocytic network, in particular the endosome‐lysosome biogenesis. Exome sequencing revealed the homozygous variant p.Leu387_ Gly395del in the VPS11 gene in two siblings. On immunoblotting, the mutant VPS11 protein showed a distinctly reduced immunostaining intensity. The children presented with primary and severe developmental delay associated with myoclonic seizures, spastic tetraplegia, trunk and neck hypotonia, blindness, hearing loss, and microcephaly. Neuro‐imaging showed severe hypomyelination affecting cerebral and cerebellar white matter and corpus callosum, in the absence of a peripheral neuropathy. Electron microscopy of a skin biopsy revealed clusters of membranous cytoplasmic bodies in dermal unmyelinated nerve axons, and numbers of vacuoles in eccrine sweat glands, similar to what is seen in a classic lysosomal storage disease (LSD). Bone marrow cytology showed a high number of storage macrophages with a micro‐vacuolated cytoplasm. Biochemically, changes in urinary glycosphingolipids were reminiscent of those in prosaposin deficiency (another LSD). The clinical and neuro‐imaged features in our patients were almost identical to those in some recently reported patients with another variant in the VPS11 gene, p.Cys846Gly; underlining the presumed pathogenic potential of VPS11 defects. A new feature was the morphological evidence for lysosomal storage in VPS11 deficiency: This newly characterised disease can be viewed as belonging to the complex field of LSD.
Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor – belinostat – in glioblastoma cell lines: a preliminary report
Authors: Kusaczuk Magdalena , Krętowski Rafał , Stypułkowska Anna , Cechowska-Pasko Marzanna 
Published: July 2016

SummaryHistone deacetylase (HDAC) inhibitors are now intensively investigated as potential cytostatic agents in many malignancies. Here, we provide novel information concerning the influence of belinostat (Bel), a hydroxamate-based pan-HDAC inhibitor, on glioblastoma LN-229 and LN-18 cells. We found that LN-229 cells stimulated with 2 μmol/L of Bel for 48 h resulted in 70 % apoptosis, while equivalent treatment of LN-18 cells resulted in only 28 % apoptosis. In LN-229 cells this effect was followed by up-regulation of pro-apoptotic genes including Puma, Bim, Chop and p21. In treated LN-18 cells only p21 was markedly overexpressed. Simultaneously, LN-229 cells treated with 2 μmol/L of Bel for 48 h exhibited down-regulation of molecular chaperones GRP78 and GRP94 at the protein level. In contrast, in LN-18 cells Western blot analysis did not show any marked changes in GRP78 nor GRP94 expression. Despite noticeable overexpression of p21, there were no signs of evident G1 nor G2/M cell cycle arrest, however, the reduction in number of the S phase cells was observed in both cell lines. These results collectively suggest that Bel can be considered as potential anti-glioblastoma agent. To our knowledge this is the first report presenting the effects of belinostat treatment in glioblastoma cell lines.
Ectopic Penile Prosthesis Reservoir Placement: An Anatomic Cadaver Model of the High Submuscular Technique
Authors: Ziegelmann Matthew J. , Viers Boyd R. , Lomas Derek J. , Westerman Mary E. , Trost Landon W. 
Published: July 2016

ABSTRACT

Introduction
High submuscular ectopic placement of inflatable penile prosthesis (IPP) reservoirs via the inguinal canal has been popularized as an alternative to the retropubic (orthotopic) location, particularly among men with prior pelvic surgery. Published results suggest minimal complications and high patient satisfaction. However, in our practice, we identified several patients presenting for IPP revision after high submuscular placement who were found to have reservoirs within the peritoneal cavity.

Aim
Given the potential for complications, we performed a cadaveric study to define the anatomic location of reservoirs placed using this technique.

Methods
We utilized 10 fresh male cadavers without embalming. Bilateral ectopic reservoir placement (10 AMS Conceal [Boston Scientific, Marlborough, MA] and 10 Coloplast Cloverleaf [Coloplast Corp, Humlebaek, Denmark]) was performed using the high submuscular technique via a penoscrotal incision. Strict adherence to published reports detailing the technique was emphasized to assure reliability of findings.

Main Outcome Measures
Anatomic dissection was performed to identify reservoir location within the abdominal wall layers.

Results
Twenty IPP reservoirs were placed without difficulty or concern for inadvertent malpositioning. Sixteen reservoirs (80%) were found anterior to the transversalis fascia, including 7 (35%) deep to the rectus muscle and 9 (45%) deep to the external oblique fascia and lateral to the rectus muscle belly. Two reservoirs (10%) were identified in the retroperitoneal space, while 1 (5%) was preperitoneal (deep to transversalis fascia) and 1 (5%) was intraperitoneal.

Conclusion
Placement of IPP reservoirs using the high submuscular technique results in variable anatomic locations, including within or immediately superficial to the peritoneal cavity. Given the lack of immediate recognition and risk of delayed complications with suboptimal reservoir placement, further studies are mandated to assess the long-term safety of the technique.
Relationship between primary restless legs syndrome and migraine with aura
Authors: Acar Bilgehan Atılgan , Acar Türkan , Alagöz Aybala Neslihan , Karacan Alper , Varım Ceyhun , Uyanık Mehmet Şevki , Kaya Tezcan , Akdemir Ramazan 
Published: July 2016

AbstractIn this study, the prevalence and characteristics of definite migraine in primary restless legs syndrome (pRLS) patients and matched control patients (CPs) were investigated. We evaluated 63 consecutive adult pRLS patients and 141 age‐ and sex‐matched controls in this case–control study. The diagnosis of migraine and its subtypes were defined based on The International Classification of Headache Disorders‐II. Only those with “definite” migraine were included in the study. The mean age of 63 adult pRLS patients (15 men and 48 women) who participated in the study was 49.4 years. A total of 27 patients (42.9%) had definite migraine. Of these migraineurs, seven (11.1%) were without aura and 20 (31.8%) were with aura. The mean age of the 141 matched CPs was 48.7 years. A total of 32 CPs (22.7%) experienced migraine. Among these 32 migraineurs, 28 (19.9%) were without aura and four (2.8%) were with aura. Migraine and migraine with aura were significantly more common in pRLS patients than in CPs. pRLS patients with migraine were more anxious and experienced a shorter duration of RLS symptoms than pRLS patients without migraine. Migraineurs in the pRLS group tended to have high scores for severity of migraine headache by Visual Analog Scale score and high levels of disability by Migraine Disability Assessment grading than those in the control group. pRLS patients showed a positive association with definite migraine headaches. In contrast to results highlighted in recent studies, we found a strong link between migraine with aura and pRLS.
Numerical and experimental validation of a morphed wing geometry using Price-Païdoussis wind-tunnel testing – CORRIGENDUM
Authors: Botez R.M. , Koreanschi A. , Sugar-Gabor O. 
Published: July 2016

The authors were listed incorrectly in the article by Botez(1). The authors should have appeared in the following order:A. Koreanschi, O. Sugar-Gabor and R.M. BotezThe article has now been updated with all authors listed in the correct order; this change has been made to the online version only.
“FILLING IN”, THOUGHT EXPERIMENTS AND INTUITIONS
Authors: Shaffer Michael J. 
Published: July 2016

AbstractRecently Timothy Williamson has argued that characterizations of the standard (i.e. intuition-based) philosophical practice of philosophical analysis are misguided because of the erroneous manner in which this practice has been understood. In doing so he implies that experimental critiques of the reliability of intuition are based on this misunderstanding of philosophical methodology and so have little or no bearing on actual philosophical practice or results. His main point is that the orthodox understanding of philosophical methodology is incorrect in that it treats philosophical thought experiments in such a way that they can be “filled in” in various ways that undermines their use as counter-examples and that intuition plays no substantial role in philosophical practice when we properly understand that methodology as a result of the possibility of such filling in. In this paper Williamson's claim that philosophical thought experiments cases can be legitimately filled in this way will be challenged and it will be shown that the experimental critique of the intuition-based methods involved a serious issue.
A dark side of political skill? Awareness and life satisfaction in a Latin American Business
Authors: Hayek Mario , Randolph-Seng Brandon , Williams Wallace Alex , Ingram Kendra 
Published: July 2016

AbstractResearch has typically explained the positive intrapsychic influence of political skill using Conservation of Resources (COR) theory. However, research explaining the possible negative intrapsychic consequences of high levels of political skill is lacking. Therefore, we introduce Cognitive Activation Theory (CAT) to the political skill literature to explain possible negative outcomes of political skill. In testing this theory, we used two hierarchical moderated multiple regressions to examine the relationship between affective and continuance commitment, life satisfaction, and political skill in a large, privately owned, financial services firm in Ecuador. Aligned with prior research, affective commitment positively affected life satisfaction; however, contrary to our hypothesis, continuance commitment also positively affected life satisfaction. Furthermore, consistent with both Conservation of Resources and Cognitive Activation Theory, results indicated that political skill strengthened the relationship between affective commitment and life satisfaction. However, contrary to Cognitive Activation Theory, political skill did not significantly weaken the relationship between continuance commitment and life satisfaction.