bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual and Haptic Perception Training to Improve Handwriting Skills in Children With Dysgraphia
Authors: Chang Shao-Hsia , Yu Nan-Ying 
Published: January 2017

Abstract
We investigated a visual–perceptual and haptic–perceptual training program to enhance motor skills and Chinese handwriting performance among children with handwriting difficulties. The participants were 28 first- and second-grade children with handwriting difficulties. They were matched according to age and then randomly assigned into a control group or an experimental group. Participants in the experimental group received 12 sessions of a training program, whereas those in the control group received conventional handwriting training. The Test of Visual Perceptual Skills—Third Edition (TVPS–3), Tactual Performance Test (TPT), and Battery of Chinese Basic Literacy (BCBL) were all administered before and after 6 wk of intervention. Repeated-measures analysis of variance revealed that the experimental group showed significant improvement on the TVPS–3 but not on the TPT. Along with the improved visual–perceptual skills, the experimental group showed a significant difference in far-point copy speed and handwriting accuracy, as reflected in the BCBL.
Uptake of nitric acid, ammonia, and organics in orographic clouds: mass spectrometric analyses of droplet residual and interstitial aerosol particles
Authors: Schneider Johannes , Mertes Stephan , van Pinxteren Dominik , Herrmann Hartmut , Borrmann Stephan 
Published: January 2017

Abstract. Concurrent in situ analyses of interstitial aerosol and cloud droplet residues have been conducted at the Schmücke mountain site during the Hill Cap Cloud Thuringia campaign in central Germany in September and October 2010. Cloud droplets were sampled from warm clouds (temperatures between −3 and +16 °C) by a counterflow virtual impactor and the submicron-sized residues were analyzed by a compact time-of-flight aerosol mass spectrometer (C-ToF-AMS), while the interstitial aerosol composition was measured by an high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS). During cloud-free periods, the submicron out-of-cloud aerosol was analyzed using both instruments, allowing for intercomparison between the two instruments. Further instrumentation included black carbon measurements and optical particle counters for the aerosol particles as well as optical sizing instrumentation for the cloud droplets. The results show that, under cloud conditions, on average 85 % of the submicron aerosol mass partitioned into the cloud liquid phase. Scavenging efficiencies of nitrate, ammonium, sulfate, and organics ranged between 60 and 100 %, with nitrate having, in general, the highest values. For black carbon, the scavenging efficiency was markedly lower (about 24 %). The nitrate and ammonium mass fractions were found to be markedly enhanced in cloud residues, indicating uptake of gaseous nitric acid and ammonia into the aqueous phase. This effect was found to be temperature dependent: at lower temperatures, the nitrate and ammonium mass fractions in the residues were higher. Also, the oxidation state of the organic matter in cloud residues was found to be temperature dependent: the O : C ratio was lower at higher temperatures. A possible explanation for this observation is a more effective uptake and/or higher concentrations of low-oxidized water-soluble volatile organic compounds, possibly of biogenic origin, at higher temperatures. Organic nitrates were observed in cloud residuals as well as in the out-of-cloud aerosol, but no indication of a preferred partitioning of organic nitrates into the aqueous phase or into the gas phase was detected. Assuming the uptake of nitric acid and ammonia in cloud droplets will be reversible, it will lead to a redistribution of nitrate and ammonium among the aerosol particles, leading to more uniform, internally mixed particles after several cloud passages.
Questioning reliability assessments of health information on social media
Authors: Dalmer Nicole K. 
Published: January 2017

This narrative review examines assessments of the reliability of online health information retrieved through social media to ascertain whether health information accessed or disseminated through social media should be evaluated differently than other online health information. Several medical, library and information science, and interdisciplinary databases were searched using terms relating to social media, reliability, and health information. While social media’s increasing role in health information consumption is recognized, studies are dominated by investigations of traditional (i.e., non-social media) sites. To more richly assess constructions of reliability when using social media for health information, future research must focus on health consumers’ unique contexts, virtual relationships, and degrees of trust within their social networks. This article has been approved for the Medical Library Association’s Independent Reading Program.
Elementos Narrativos que Sirven para Generar Convergencias e Inteligibilidad en Narrativas Transmediáticas o Narrativas Interactivas Lineales.
Authors: Mora Fernández Jorge Ignacio 
Published: January 2017

El término transmedia fue acuñado por Marsha Kinder (1991) para referirse a la intertextualidad entre películas, series de televisión de dibujos y los juguetes para niños y jóvenes preadolescentes. En dicha publicación participaba Henry Jenkins, quien posteriormente profundizó en el término de transmedia en Media Convergence (2006) y posteriormente en narrativa transmedia. La presente investigación analiza el uso de los elementos narrativos y de las características de los medios de comunicación utilizados para generar narrativas transmedia para poder utilizarlas en productos comunicativos independientes. Este artículo se concentra en el análisis transmedia del universo narrativo generado por los cómics, películas, web, videos de fans y videojuegos de Batman. El objetivo es el estudio de los elementos narrativos de las acciones, personajes, espacios y tiempos utilizados para generar convergencia e inteligibilidad comunicativas transmedia que retroalimentan coherentemente el universo de Batman, sus narrativas interactivas lineales y circulares. De esta forma es posible aplicar dichas técnicas narrativas transmedia a la construcción de productos comunicativos independientes y de edutainment.
ANEXO I
DESCARGAR
On the Mistranslation of Daraba in the Holy Quran
Authors: Qorchi Bouchra 
Published: January 2017

Improper, or literal translations of the Quran may be one of the reasons behind misinterpretations of this sacred text. This paper deals with translations of one of the most controversial verses in the Quran, one that has brought about a great deal of misunderstanding about Islam and the status of women in this religion. It is verse 34 of Surah Annissae (the surah of Women). In this verse, according to many translators, God ordered men to beat their wives. In this paper, I will try to show that beat, hit or strike are just some of a hord of meanings that the root drb (from which the verb daraba is derived) has, and that it is not necessarily this meaning that the Holy Quran intends to convey in this surah.
Frequência de polimorfismos do gene TMEM18 numa população de crianças participantes de um estudo de coorte em Salvador – BA
Authors: Villar Maria Eduarda , Carrijo Fabiane Tavares , Ramos Helton Estrela , Figueiredo Camila Alexandrina Viana de 
Published: January 2017

<p><strong>Introdução:</strong> O <em>TMEM18</em> é um gene localizado no cromossomo 2p25.3. A recente ligação deste gene à obesidade tem sido replicada em diversos estudos de associação genômica para algumas variantes alélicas. O presente artigo analisou as frequências alélicas e genotípicas de polimorfismos no gene <em>TMEM18 </em>numa amostra da população de Salvador – BA, e a diferença das MAFs encontradas em relação às principais populações que respondem pela composição étnica do Brasil – ameríndios, africanos e europeus. <strong>Metodologia:</strong> participaram deste estudo 1308 crianças com idade entre 4 a 11 anos, integrantes de um estudo de coorte do projeto <em>Social Changes, Asthmaand Allergy in LatinAmerica </em>(SCAALA)<em>. </em>Para a genotipagem dos indivíduos foi utilizado o painel comercial Illumina Human Omni 2, com aproximadamente 2.5 milhões de marcadores. Utilizamos os <em>softwares</em> PLINK (PURCELL et al., 2007) e <em>Haploview</em> (<em>BROAD Institute</em>) para controle de qualidade dos SNPs e análise de agregação de haplótipos (<em>Linkage Desequilibrium</em> - LD&gt;4.2%), respectivamente. <strong>Resultados:</strong> As variantes do gene <em>TMEM18 </em>encontradas localizam-se na região 3´UTR (rs17729501, rs17042334, rs3187671) e intrônica (rs73153245, rs73153246, rs4241323, rs12990777, e rs2293084). Todos os polimorfismos estão em equilíbrio de Hardy-Weinberg. As frequências dos alelos menos frequentes (MAFs) observadas (9% e 9,3%) foram para os SNPs rs17729501 ers17042334, respectivamente. Os polimorfismos com as menores MAFs - s17729501 (9%) e rs17729501 (9,3%) - apresentaram, simultaneamente, as menores frequências genotípicas para homozigose, 0,5% (C/C) e 0,8% (T/T), respectivamente. As maiores taxas de heterozigose observadas na população foram de 44% (A/C - rs2293084) e 47,3% (G/A -rs12990777) e correspondem às maiores frequências alélicas (rs2293084 – 34,9%; rs12990777 - 47,3%). Os SNPs rs3187671, rs73153245 e rs73153246 estão em desequilíbrio de ligação. <strong>Conclusão:</strong> As frequências alélicas obtidas para os SNPs, de uma forma geral, diferiram das frequências registradas para populações de referência. O presente trabalho contribuiu com informações sobre a ocorrência de polimorfismos no <em>TMEM18 </em>na população brasileira, bem como com as frequências alélicas dos SNPs analisadas para os futuros estudos do tipo GWAS.</p><p> </p>
Surfactant‐Assisted Suzuki–Miyaura Coupling Reaction of Unreactive Chlorobenzene over Hydrotalcite‐Supported Palladium Catalyst
Authors: Choudhary Hemant , Jia Jixiang , Nishimura Shun , Ebitani Kohki 
Published: January 2017

AbstractA hydrotalcite‐supported palladium chloride (PdCl2/HT) catalyst has been developed for the Suzuki–Miyaura coupling (SMC) reaction. As‐prepared PdCl2/HT effectively catalyzed the SMC reaction of bromobenzene under air to afford >99 % biphenyl yields and the catalyst could be reused without any significant loss in catalytic activity. The moderate activity (69 % biphenyl yields) of the PdCl2/HT catalyst for chlorobenzene was improved, resulting in biphenyl yields of up to 96 % using a surfactant as an additive. Among various surfactants employed, Triton X‐100 (TX‐100) enhanced the catalytic performances of PdCl2/HT the most. The X‐ray photoelectron spectroscopy (XPS) and X‐ray absorption spectroscopy (XAS) of bare and surfactant‐treated PdCl2/HT catalysts depicted the ligation of the Pd species by TX‐100 influenced the electronic structure of the Pd species, leading to efficient catalysis.
Influence of hyaluronic acid on the formation of isolated poly(vinyl acetate) films for oral solid coatings
Authors: Zanin Giovane Douglas , Bunhak Élcio Jose , dos Santos Leandro Freire , de Melo Eduardo Borges , Cavalcanti Osvaldo Albuquerque 
Published: January 2017

ABSTRACTThis article presents a preformulation study of isolated poly(vinyl acetate) films with the addition of hyaluronic acid (HA). The films were prepared with the solvent evaporation method and evaluated according to macroscopic, morphologic, structural, water vapor transmission (WVT), swelling index (Si%), and thickness measurements and thermal analyses. The addition of HA resulted proportional reductions in the thickness, transparency, and flexibility and increased WVT rates and Si%. Fourier transform infrared spectra demonstrated that only physical mixing occurred, whereas the thermogravimetric analysis and differential scanning calorimetry curves indicated that the films were thermally stable because the initial decomposition temperature was above 200 °C. The electron micrographs showed modifications in the structure of the polymeric mesh after imersion of films in simulated gastric or intestinal fluids. The prepared films have potential for application in pharmaceutical modification of drug release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44815.
Evaluation of horizontal stiffness of fibre‐reinforced elastomeric isolators
Authors: Van Ngo Thuyet , Dutta Anjan , Deb Sajal K. 
Published: January 2017

SummaryUnbonded fibre‐reinforced elastomeric isolator (U‐FREI) is relatively new seismic base isolator in which fibre layers are used as reinforcement to replace steel shims as are normally used in conventional isolators. Further, the top and bottom end steel connector plates of conventional isolators are also removed. In general, the horizontal response of U‐FREI is nonlinear because of reduction in contact area due to rollover deformation and reduction in shear modulus of isolator under large deformation. Thus, evaluation of horizontal stiffness of U‐FREI is a challenging problem. Most previous studies were focused on the investigation of horizontal response of scaled models of U‐FREIs with low shape factors. A few analytical approaches were suggested for predicting the horizontal response of U‐FREI; but their results were not in good agreement with experimental observations. In the present study, the horizontal responses of prototype U‐FREIs are evaluated under a constant vertical pressure and cyclic loading using both experiments and finite element analysis. Prototype U‐FREIs with different shear moduli and with different shape factors are considered. Finite element simulations of corresponding bonded FREIs are also performed under the same loadings as in U‐FREIs. A rational analytical approach including the influence of rollover deformation and simultaneous reduction in shear modulus is proposed as a basic analytical tool for predicting the horizontal stiffness of FREIs (both bonded and unbonded). It is in reasonably good agreement with the results obtained from experiments and numerical analysis. Copyright © 2017 John Wiley & Sons, Ltd.
Current and prospective sights in mechanism of deoxynivalenol‐induced emesis for future scientific study and clinical treatment
Authors: Chen Liangkai , Peng Zhao , Nüssler Andreas K. , Liu Liegang , Yang Wei 
Published: January 2017

AbstractDeoxynivalenol (DON), one of trichothecene mycotoxins produced by the fungus Fusarium, is commonly detected in cereal foods and in secondary food production across the world. Lower concentrations of DON induce a dose‐related feed refusal (anorexia), whereas it acts as a potent emetic agent at higher levels. DON‐induced emesis in humans and livestock can be observed and recorded in both undeveloped and developed regions such as Lixian, Guide and Huangzhong in China and Illinois in the USA. Some studies with different animal models (pigs and minks) suggested that DON could change expressions of 5‐hydroxytryptamine, peptide YY, neuropeptide Y2 receptor and nucleobindin‐2/nesfatin‐1 in plasma and different areas of the brain. Some selective antagonist of 5‐hydroxytryptamine 3 receptors can inhibit DON‐induced emetic response. Otherwise, the Ca2+ homeostasis and MAPK pathway could be potential directions in future studies. Dolasetron, dantrolene and JNJ‐31020028 can be used in clinical treatment but they have potential toxic effects. (−)Epicatechin, ginger phytochemicals and isoflavone can be tested in in vitro and in vivo for their usage as food additives for reducing the emesis. The present review summarizes and discusses some information from previous and recent prominent publications with the aim to provide some comprehensive and helpful data for understanding the mechanism of DON‐induced emesis. Copyright © 2017 John Wiley & Sons, Ltd.
Quantitative evaluation of root canal surface roughness after filing with adaptive reciprocating and continuous rotary instruments
Authors: Sakhaei Manesh Vahid , Giacomin Paul , Stoll Richard 
Published: January 2017

AbstractObtaining clean and smooth root canal walls is the ideal clinical outcome of the cleaning and shaping stage in root canal treatment. This study compares the surface roughness of root canal surfaces instrumented with a NiTi filing system with either adaptive reciprocating (AR) or continuous rotation (CR). Root canal cleaning and shaping was carried out on the mesial canals of 24 extracted first molars roots with either AR or CR. Roots were split in half and the surface roughness of their canals was evaluated in 12 three dimensional roughness reconstructions using a scanning electron microscope. Rz (nm) values were calculated in three areas of each reconstruction and analyzed (α = 0.05). Mann‐Whitney tests showed that surface roughness was significantly higher overall in the AR group (Rz = 967 ± 250 nm) compared with the CR group (Rz = 739 ± 239 nm; p = 0.044). The roughness values generally increased from apical towards the coronal third in both groups. A less aggressive finishing file or a continuous rotary system to end the cleaning and shaping stage may be beneficial to reduce roughness of the root canal surface.
Inhibition of Aquated Sulfur Dioxide Autoxidation by Aliphatic, Acyclic, Aromatic, and Heterocyclic Volatile Organic Compounds
Authors: Meena Vimlesh Kumar , Dhayal Yogpal , Rathore Deepak Singh , Singh Chandel C. P. , Gupta K. S. 
Published: January 2017

ABSTRACTThe oxidation of dissolved sulfur dioxide, sulfur(IV), by oxygen proceeds through the involvement of sulfoxy radicals among which sulfate radical anion is the main chain carrier. When organics are present, they inhibit the oxidation of sulfur(IV) via scavenging of SO4− radicals. In contrast to previous studies, which were limited mostly to aliphatic compounds, this paper presents the results of the effect of 13 new volatile organic compounds (VOCs) including aromatic and heterocyclic on uncatalyzed sulfur(IV) autoxidation at pH 8.2 and 25°C. In all cases, the kinetics was first order in the presence and absence of VOCs and experimental rate law was Eq. (1).
urn:x-wiley:05388066:media:kin21069:kin21069-math-0001where −d[S(IV)]/dt is the rate of sulfur(IV) disappearance, kobs is the first‐order rate constant in the presence of inhibitor, ko is the first‐order rate constant in the absence of inhibitor, [S(IV)] is concentration of sulfur(IV) at time, t, and B is an inhibition parameter.VOCs cause inhibition by scavenging sulfate radical anions, which propagate the autoxidation chain. An analysis of B (Eq. (1)) and kinh (Eq. (2)) values for 21 aliphatic, aromatic, acyclic, and heterocyclic organic compounds showed that these to be related by Eq. (3) for a subgroup and Eq. (4) for b subgroup.
urn:x-wiley:05388066:media:kin21069:kin21069-math-0002a subgroup (benzamide, 2,2‐dimethyl‐1‐propanol, 1‐hexanol, methanol, ethanol, 1‐propanol, 2‐ propanol, 1‐butanol, 2‐butanol, ethylene glycol, rebaudioside A)
urn:x-wiley:05388066:media:kin21069:kin21069-math-0003b subgroup (o‐toluic acid, m‐toluic acid, p‐toluic acid, 4‐hydroxybenzoic acid, 1‐heptanol, glycerol, sucralose, acesuifame K, glycine, 3‐pentanol)
urn:x-wiley:05388066:media:kin21069:kin21069-math-0004
Frequent low‐level mutations of protein kinase D2 in angiolipoma
Authors: Hofvander Jakob , Arbajian Elsa , Stenkula Karin G , Lindkvist‐Petersson Karin , Larsson Malin , Nilsson Jenny , Magnusson Linda , von Steyern Fredrik Vult , Rissler Pehr , Hornick Jason L , Mertens Fredrik 
Published: January 2017

AbstractTumours displaying differentiation towards normal fat constitute the most common subgroup of soft tissue neoplasms. A series of such tumours was investigated by whole‐exome sequencing followed by targeted ultra‐deep sequencing. Eighty per cent of angiolipomas, but not any other tumour type, displayed mutations in the protein kinase D2 (PRKD2) gene, typically in the part encoding the catalytic domain. The absence of other aberrations at the chromosome or RNA level suggests that PRKD2 mutations are critical for angiolipoma development. Consistently, the mutated PRKD2 alleles were present at low (3–15%) frequencies, indicating that only a subset of the tumour cells is affected. Indeed, by sequencing mature fat cells and other cells separately, the former typically showed the highest mutation frequencies. Thus, we hypothesize that altered PRKD2 signalling in the adipocytic cells drives tumourigenesis and, in agreement with its pivotal role in angiogenesis, induces the vessel formation that is characteristic for angiolipoma. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Incorporating an allosteric regulatory site in an antibody through backbone design
Authors: Khersonsky Olga , Fleishman Sarel J. 
Published: January 2017

AbstractAllosteric regulation underlies living cells' ability to sense changes in nutrient and signaling‐molecule concentrations, but the ability to computationally design allosteric regulation into non‐allosteric proteins has been elusive. Allosteric‐site design is complicated by the requirement to encode the relative stabilities of active and inactive conformations of the same protein in the presence and absence of both ligand and effector. To address this challenge, we used Rosetta to design the backbone of the flexible heavy‐chain complementarity‐determining region 3 (HCDR3), and used geometric matching and sequence optimization to place a Zn2+‐coordination site in a fluorescein‐binding antibody. We predicted that due to HCDR3's flexibility, the fluorescein‐binding pocket would configure properly only upon Zn2+ application. We found that regulation by Zn2+ was reversible and sensitive to the divalent ion's identity, and came at the cost of reduced antibody stability and fluorescein‐binding affinity. Fluorescein bound at an order of magnitude higher affinity in the presence of Zn2+ than in its absence, and the increase in fluorescein affinity was due almost entirely to faster fluorescein on‐rate, suggesting that Zn2+ preorganized the antibody for fluorescein binding. Mutation analysis demonstrated the extreme sensitivity of Zn2+ regulation on the atomic details in and around the metal‐coordination site. The designed antibody could serve to study how allosteric regulation evolved from non‐allosteric binding proteins, and suggests a way to designing molecular sensors for environmental and biomedical targets.
Answers to Some Questions Concerning Rings with Property (A)
Authors: Hashemi E. , Estaji A. AS. , Ziembowski M. 
Published: January 2017

AbstractA ring R has right property (A) whenever a finitely generated two-sided ideal of R consisting entirely of left zero-divisors has a non-zero right annihilator. As the main result of this paper we give answers to two questions related to property (A), raised by Hong et al. One of the questions has a positive answer and we obtain it as a simple conclusion of the fact that if R is a right duo ring and M is a u.p.-monoid (unique product monoid), then R is right M-McCoy and the monoid ring R[M] has right property (A). The second question has a negative answer and we demonstrate this by constructing a suitable example.
Bodily arousal differentially impacts stimulus processing and memory: Norepinephrine in interoception
Authors: Critchley Hugo D. , Garfinkel Sarah N. 
Published: January 2017

AbstractBodily arousal modulates stimulus processing and memory, contributing to expression of emotional salience. The “glutamate amplifies noradrenergic effects” (GANE) model proposed by Mather and colleagues can be extended to account for the differential impact of interoceptive (notably cardiac afferent) signals on sensory processing. However, some emotion-specific effects, for example, for fear, may further depend on functional anatomical organisation of affect-related brain structures.