bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional screen for mediators of onco-mRNA translation specificity
Authors: Kovalski Joanna R. , Sarioglu Goksu , Subramanyam Vishvak , Hernandez Grace , Rademaker Gilles , Oses-Prieto Juan A. , Slota Macey , Mohan Nimmy , Yiakis Kaylee , Liu Isabelle , Wen Kwun Wah , Kim Grace E. , Miglani Sohit , Burlingame Alma L. , Goodarzi Hani , Perera Rushika M. , Ruggero Davide 
Published: October 2024

ABSTRACTOncogenic protein dosage is tightly regulated to enable cancer cells to adapt and survive. Whether this is regulated at the level of translational control and the key factors incisandtransremain unknown. The Myc oncogene is a central paradigm of an exquisitely regulated oncogene and a major driver of pancreatic ductal adenocarcinoma (PDAC). Using a functional genome-wide CRISPRi screen in PDAC cells, we identified activators of selectiveMYCtranslation through its 5’ untranslated region (5’UTR) and validated four RNA binding proteins (RBPs), including epitranscriptome modifiers. Among these RBPs, our top hit was RBM42, which is highly expressed in PDAC and predicts poor survival. Combining polysome sequencing and CLIP-seq analyses, we find that RBM42 binds and selectively regulates the translation ofMYCand a precise, yet vital suite of pro-oncogenic transcripts, includingJUNandEGFR. Mechanistically, employing IP-mass spectrometry analysis, we find that RMB42 is a novel ribosome-associated protein (RAP). Using DMS-Seq and mutagenesis analysis, we show that RBM42 directly binds and remodels theMYC5’UTR RNA structure, facilitating the formation of the translation pre-initiation complex. Importantly, RBM42 is necessary for human PDAC cell growth and fitness and PDAC tumorigenesis in xenograft mouse models in a Myc-dependent mannerin vivo. In PDAC patient samples, RBM42 expression is correlated with Myc protein levels and transcriptional activity. This work transforms our understanding of the translational code in cancer and offers a new therapeutic opening to target the expression of oncogenes.
Longitudinal monitoring of respiratory syncytial virus, SARS-CoV-2 and influenza in wastewater of a Southern Indian city
Authors: Venkatesh Apoorva , Sreelekshmi RS , Movva Parishuddha Babu , Madhukar Manas K , Panda Aruna , Mohan S. Venkata , Mishra Rakesh , Moharir Shivranjani C 
Published: October 2024

AbstractThe detection of diverse pathogens and chemical compounds in community wastewater facilitates the monitoring of public health trends of emerging diseases and health conditions. During the COVID-19 pandemic, detection of viral RNA in wastewater assisted in monitoring the infection rates in different geographies and this drew attention to the method of wastewater-based epidemiology (WBE). In contrast to individual clinical testing, WBE offers an affordable, population-wide overview of the infection status of a community including asymptomatic carriers and those without access to healthcare facilities. To understand the community status of the infections caused by respiratory syncytial virus, SARS-CoV-2 and influenza virus subtypes in the monsoon season in Vijayawada city in the state of Andhra Pradesh in India, we longitudinally analyzed wastewater samples once a week between July-August 2024 from 7 sewage treatment plants in the city. The data obtained from the multiplexed RT-qPCR was used to calculate the viral loads in the wastewater samples at the city level and the proportion of population shedding the virus was estimated. All three viruses RSV A+B, SARS-CoV-2 and Influenza A+B were detected in the wastewater during our sampling period. Amongst the three viruses, the city had the largest load of SARS-CoV-2 RNA in the wastewater followed by RSV A+B and Influenza A+B. The study demonstrates the potential of utilizing wastewater surveillance system coupled to multiplexed RT-PCR to understand the population level dynamics of co-existence of multiple pathogens during the monsoon season in the urban settings.
Protein aggregation drives cell aging in a size-specific manner inEscherichia coli
Authors: Wagener Linda , Nath Arpita , Tuğrul Murat , Aertsen Abram , Steiner Ulrich K. , Proenca Audrey M. 
Published: October 2024

ABSTRACTAging, the decline in physiological function over time, is marked by the intracellular accumulation of damaged components. It can be attributed to a trade-off between the investment into organismal maintenance and the production of high-quality offspring, where the parent accumulates damage over time and retains it upon reproduction, while the offspring is rejuvenated. Asymmetric damage partitioning has been observed even in simple unicellular organisms, such asEscherichia colicells that retain aggregates of misfolded proteins during cell division. However, recent studies presented conflicting evidence on the effect of protein aggregates on fitness, ranging from detrimental effects on cell growth to enhanced stress survival. Here, we show that the decisive factor driving growth decline inE. coliis not the presence of a protein aggregate, but the proportion of the intracellular space occupied by it. By following single-cellE. colilineages expressing fluorescently labeled DnaK chaperones, we quantified damage accumulation and partitioning across generations in microfluidic devices. Our results suggest that the aggregation of damaged proteins allows cells to keep damage separate from vital processes and compensate for the lost intracellular space by growing to larger sizes, a process which results in morphologically asymmetrical divisions. In line with other recent evidence, this points to a more complex role of protein aggregation, with implications for our understanding of the cellular mechanisms underlying aging as well as its evolutionary origins.
Identification of targetable epigenetic vulnerabilities for uveal melanoma
Authors: Yenisehirli G. , Borges S. , Braun S. , Zuniga A. N. , Quintana G. I. , Kutsnetsoff J. N. , Rodriguez S. , Adis E. V. , Lopez S. , Dollar J. J. , Stathias V. , Volmar C. H. , Karaca E. , Brothers S. P. , Bilbao D. C. , Harbour J. W. , Correa Z. M. , Kurtenbach S. 
Published: October 2024

ABSTRACTUveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a strong predilection for hepatic metastasis, occurring in approximately 50% of cases. Metastatic UM remains highly resistant to therapy and is almost invariably fatal. The strongest genetic drivers of UM metastasis are loss-of-function mutations in tumor suppressorBAP1, an epigenetic regulator that serves as the ubiquitin hydrolase subunit of the polycomb repressive deubiquitinase (PR-DUB) complex, and a key player in global epigenetic regulation. Inactivation of BRCA Associated Protein 1 (BAP1) has been shown to induce widespread epigenetic alterations across multiple model systems. To identify novel therapeutic strategies, we investigated whether targeting the epigenome could reveal new vulnerabilities in UM. We performed high-throughput compound screening using a curated epigenetic inhibitor library and identified BET (bromodomain and extra-terminal domain) inhibition as a particularly promising approach. Interestingly, we observed significant heterogeneity in the efficacy of different BET inhibitors in UM. While previous clinical trials with two BET inhibitors have failed to show efficacy in UM, our findings highlight substantial differences in the potency of specific BET inhibitors for this malignancy. Notably, the BET inhibitor mivebresib (ABBV-075) significantly improved survival rates by 50% in a metastatic UM xenograft mouse model and completely prevented detectable metastases in the bones, spinal cord, and brain. Unexpectedly, RNA sequencing revealed a strong transcriptional overlap between BET inhibition and histone deacetylase (HDAC) inhibition--an approach currently under clinical evaluation for UM treatment. Both BET and HDAC inhibitors reversed gene expression signatures associated with high metastatic risk and induced a neuronal differentiation-like phenotype in UM cells. Together, our findings demonstrate that UM cells exhibit a distinct vulnerability to BET inhibition and establish BET inhibitors as promising candidates for further clinical evaluation for metastatic UM.
Institutional quality and economic growth in upper-middle-income African countries
Authors: Gebrue Negussie 
Published: October 2024

PurposeTo determine which proxy institutional quality variables are most significant for a country’s economic growth, the paper aims to investigate the effect of institutional quality on economic growth in upper-middle-income African nations between 2002 and 2021.Design/methodology/approachIn an attempt to account for countries' heterogeneity, the study uses a random and fixed effect model estimated by the generalized least squares.FindingsThe empirical findings demonstrate that the institutional quality measures of political stability, voice and accountability, corruption control and violence absence are statistically and favorably significant factors influencing the economic growth of upper-middle-income African countries.Originality/valueThis paper is unique in that it uses both random and fixed effects models to determine the effect of institutional quality on economic growth in the context of upper-middle-income African countries between 2002 and 2021.
Nutritional behavior: a child’s play? A systematic review on the effectiveness of digital edutainment games in improving nutrition behavior among school-going children
Authors: Mohapatra Subhashree , Mohandas Rahul 
Published: October 2024

PurposeSince youngsters are being extensively engaged with digital devices these days, integrating digital technologies into food and nutrition education programs, stands out as a viable method. The current systematic review aimed to assess the available literature on the effectiveness of digital edutainment games on nutrition behavior of school-going children.Design/methodology/approachFrom the earliest date available until September 30, 2023, a comprehensive search was conducted in databases such as PubMed, Cochrane, Scopus, Lilacs, Science Direct, Web of Science and Google Scholar to identify relevant articles. Only randomized controlled studies were included in the review. Seven full-text publications that fulfilled the eligibility criteria were subjected to additional data extraction processing.FindingsChildren’s dietary behavior was found to be improved by playing digital games because they are entertaining and pleasurable. The majority of the studies' favored game type was game-based simulations. In terms of pedagogical role, all the studies were independent and not complementary to traditional conventional classroom lectures.Research limitations/implicationsBased on the results, digital educational games show promising results in terms of acceptability and early impacts on reducing sugar intake and enhancing dietary habits in school-age children. However, it is necessary to conduct more research to determine the essential elements of these games, their duration of usefulness and their generalizability.Originality/valueThis review contributes to the researchers and academicians by providing relevant information regarding effectiveness of digital edutainment games on nutrition behavior of school-going children. This is the first systematic review conducted to assess the effectiveness of digital edutainment games on nutrition behavior of school-going children.
Ambivalent perception of cause-related marketing: investigating the (in)congruence of opposite motivational perceptions on consumer evaluations
Authors: Wang Yuting , Chen Yao , Fang Jie , Xiong Bingqing 
Published: October 2024

PurposeDespite the popularity of leveraging cause-related marketing (CRM) to make societal contributions and bolster business profits, sellers face a profound dilemma when conducting CRM due to consumers’ ambivalent understanding of sellers’ motivation for the initiative. Therefore, it is imperative to unravel consumers’ ambivalent understanding of CRM and determine how sellers can effectively employ CRM to elicit positive evaluations from consumers.Design/methodology/approachThis study gathered survey data from 217 participants and applied a polynomial regression model and response surface analysis for disentangling ambivalent perception of CRM by investigating the influence of (in)congruence between perceived egoistic and altruistic motivation.FindingsThe incongruence between perceived egoistic and altruistic motivation can positively influence consumers’ evaluations of sellers. Moreover, when perceived egoistic and altruistic motivations are congruent, increasing their absolute level also enhances consumers’ evaluation of sellers. Moreover, sellers’ platform function usage behavior can amplify the positive effect of incongruence but has no salient moderating role on the congruence effect.Originality/valueDiffering from prior literature that predominantly focused on either the positive or negative interpretation of CRM, this study reveals the coexistence of both positive and negative viewpoints and disentangles the congruence and incongruence effect between the two motivational understandings.
The impact of R&D organizational structure on developing technological capabilities and the moderation of R&D slack
Authors: Tsai-Lin Tung-Fei , Chen Ming-Huei , Chi Hui-Ru , Chiang Pei-Shan 
Published: October 2024

PurposeDeveloping technological capabilities to enhance innovation performance is essential for firms to respond to external changes and competition. Based on the effect of organizational structure on organizational capability development, this study assesses whether a specific R&D organizational structure design can be used to develop different technological capabilities.Design/methodology/approachCombining organizational theory and the resource-based view as an integrated view, we propose several contrasting hypotheses to show the effects of three general R&D organizational structure designs (centralized, decentralized, and hybrid) on developing exploitative and explorative capabilities. We propose R&D slack as a moderator. 82 Taiwanese listed manufacturing firms were selected. Data on the firms' annual reports and their patent applications to the Taiwan Patent Office from 2005 to 2017 were collected.FindingsFirms’ adoption of centralized and decentralized R&D structures has a significant positive effect on developing exploitative capability and an opposite effect on developing explorative capability. A high or low R&D slack can moderate the impact of R&D organizational structure on non-routine capability development.Research limitations/implicationsThis study concludes that R&D organizational structure affects the development of different technological capabilities and that the effect of R&D organizational structure on the development of technological capabilities can be changed under the moderation of R&D slack, which means that the possibility of developing different technological capabilities under the same organizational structure will increase.Practical implicationsThe top manager should consider the relationship between R&D structure design and technological capability development to manage the R&D routines to influence the generation of technological capabilities. Also, they must utilize the provision of R&D slack to modulate technological capability development.Originality/valueThis study reexamines the relationship between organizational structure and capability development. It shows that organizational structure can shape unique technological capabilities and that firms may be able to change structural elements through slack resources, enabling ambidexterity or dynamic capability development without organizational change.
Approaching beyond reality to connect realism in the library
Authors: De Sarkar Tanmay 
Published: October 2024

Purpose
The purpose of this study is to investigate how libraries adopt beyond reality technologies like virtual reality, augmented reality, mixed reality and extended reality to provide an engaging environment and transform user service provision.

Design/methodology/approach
The study explained different facets of beyond reality. It surveyed various library websites and analysed literature dealing with varying forms of beyond reality technology to gain an idea of how libraries perceive the relevance of this emerging technology for incorporation in its workflow.

Findings
The study presented some use case studies to give an overview of the adoption of this technology in libraries. The study also outlines the scope of future possibilities for the expansion of applications.

Originality/value
The practical examples will help improve the understanding of practicing librarians who are contemplating implementation or preparing to cover more areas under this technology in libraries and encourage researchers to explore the integration of artificial intelligence and machine learning with this technology in a cloud infrastructure to leverage maximum outcome in a broader perspective from this immersive technology.
A unified calibration method for robot manipulators: hand-eye parameters, kinematic parameters and TCP position calibration
Authors: Min Kang , Ni Fenglei , Chen Zhaoyang , Liu Hong 
Published: October 2024

Purpose
The purpose of the paper is to propose an efficient, simple and concise unified robot calibration method that simultaneously considers errors in hand-eye parameters, kinematic parameters and tool center point (TCP) position.

Design/methodology/approach
This paper proposes a unified robot calibration method. First, the initial hand-eye matrix and TCP position are computed without considering kinematic parameter errors. Second, the nominal TCP positions in the laser tracker coordinate system {S} are computed. The actual TCP positions in {S} are directly measured. Third, a unified parameter error calibration model is established, and the sequential quadratic programming algorithm is used for error identification. Finally, the identified errors are used for direct error compensation.

Findings
Simulation results prove that the proposed scheme can accurately calibrate the hand-eye parameters, kinematic parameters and TCP position simultaneously. Experimental results reveal that the maximum value of the absolute positioning errors is reduced from 5.4725 mm to 0.4095 mm (reduced by 92.52%). Thus, the proposed approach meets the accuracy requirements of most robotic applications.

Originality/value
The main contributions of this paper are: (1) this scheme is efficient. The method can achieve fully automatic calibration by incorporating Kronecker products for the initial hand-eye matrix and TCP position computation. Thereby significantly improving the calibration efficiency and liberating the labor force. (2) This scheme is simple and concise. The hand-eye parameters, kinematic parameters and TCP position errors are modeled in a unified framework. Furthermore, the related redundant parameters are deleted.
Environmental, social and governance (ESG) performance and abnormal positive tone
Authors: Yang Xin , Bao Jingwei , Zhang Kezhen 
Published: October 2024

Purpose
The purpose of this study is to explore the relationship between environmental, social and governance (ESG) performance and tone management in the annual report. This is based on the notion that managers, driven by personal interests, may use their ESG accomplishments by using an abnormal positive tone to enhance their reputation or career prospects.

Design/methodology/approach
Using panel data from Chinese listed companies from 2010 to 2022, this study first investigates the relationship between ESG performance and abnormal tone management. The study then uncovers this relationship is mediated through the mechanisms of equity-based incentive and analyst coverage. The conclusions of this paper hold even after a series of robustness tests, such as propensity score matching, Heckman two-stage method and two-stage least squares with instrumental variables.

Findings
This study finds a positive correlation between ESG performance and the presence of abnormal positive tone in annual reports. Furthermore, the mechanistic analysis reveals that managers in companies with strong ESG performance are motivated to use an overly positive tone, largely due to their vested interests in equity-based compensation. Moreover, in an effort to alleviate the pressure stemming from heightened financial analyst coverage and enhance the impression conveyed through analysts' reports, managers with superior ESG performance also tend to inflate the tone within their annual reports.

Practical implications
This study provides significant insights into the ongoing dialogue surrounding ESG-related equity incentives, which incentivize managerial manipulation of stock prices through the use of abnormal positive tone. The findings call upon investors to exercise greater vigilance in examining narrative information in annual reports, as abnormally positive tones may not always faithfully represent performance but rather reflect managerial self-interest.

Social implications
There is an emphasis on the importance of robust oversight mechanisms within corporate governance bodies to curb the manipulation of tone for managers’ personal gain.

Originality/value
This study enhances the theoretical foundation of ESG studies, offering a holistic perspective on the intricate interplay among ESG performance, managerial behavior and financial markets, with potential implications for researchers, investors and regulators.
Research on underwater acoustic detection technology based on optical waveguide resonator cavity
Authors: Yajie Wang , Zhang Wendong , Cui Jiangong , Chu Xiaoxia , Zhang Guojun , Wang Renxin , Huang Haoming , Zhai Xiaoping 
Published: October 2024

Purpose
In acoustic detection technology, optical microcavities offer higher detection bandwidth and sensitivity than traditional acoustic sensors. However, research on acoustic detection technologies involving optical microcavities has not yet been reported. Therefore, this paper aims to design and construct an underwater acoustic detection system based on optical microcavities and study its acoustic detection technology to improve its performance.

Design/methodology/approach
Based on the principles of optical microcavity acoustic sensors, a signal-detection circuit was designed to form a detection system in conjunction with a laser, an optical waveguide resonator and an oscilloscope. This circuit consists of two modules: a photodetection module and a filter amplification module.

Findings
The photodetection module features a baseline noise of −106.499 dBm and can detect device spectral line depths of up to 2410 mV. The gain stability of the filter amplification module was 58 dB ± 1 dB with a noise gain of −107.626 dBm. This design allows the acoustic detection system to detect signals with high sensitivity within the 10 Hz−1.2 MHz frequency band, achieving a maximum sensitivity of −126 dB re 1 V/µPa at 800 Hz and a minimum detectable pressure (MDP) of 0.37 mPa/Hz1/2, corresponding to a noise equivalent pressure (NEP) of 51.36 dB re 1 V/µPa.

Originality/value
This study designs and constructs a broadband underwater acoustic detection system specifically for optical waveguide resonators based on the sensing principles of silicon dioxide optical waveguide resonators. Experiments demonstrated that the signal detection module improves the sensitivity of underwater acoustic detection based on optical waveguides.