bluuebunny/crossref_metadata_2025_split huggingface dataset:
We Hope You're Listening: Qualitative Study of Advice Given by Individuals with Parkinson's Disease
Authors: Kinger Shraddha B. , Moran Jacqueline , McLarin Amber , Fox‐Fuller Joshua T. , Salazar Robert D. , Gordillo Monica L. , Long Kristin A. , Cronin‐Golomb Alice 
Published: September 2024

AbstractBackgroundPatient‐centered care for persons with Parkinson's disease (PwPD) is associated with positive outcomes, but is lacking in current healthcare systems.ObjectiveIn this qualitative study, we solicited advice from PwPD to medical professionals, family members/friends, and newly‐diagnosed PwPD.MethodsThrough an online survey, 275 PwPD answered open‐ended questions asking for their advice. Responses were analyzed using content analysis. Interrater reliability was 94.5%.ResultsThree qualitative themes were identified. First, participants advised enhancing care and communication, with healthcare professionals balancing clinical constraints with compassion, and family/friends balancing support with appreciating autonomy of PwPD. The second theme was empowering PwPD through increasing their knowledge of the disease and care options. The third reflected the importance of focusing on well‐being and connection.ConclusionThe results highlight several gaps in meeting the needs of PwPD in healthcare settings and personal relationships, underscoring the importance of integrating their perspectives in shaping approaches to care.
Particle‐based MR modeling with diffusion, microstructure, and enzymatic reactions
Authors: Dingwell Dylan Archer , Cunningham Charles H. 
Published: September 2024

AbstractPurposeTo develop a novel particle‐based in silico MR model and demonstrate applications of this model to signal mechanisms which are affected by the spatial organization of particles, including metabolic reaction kinetics, microstructural effects on diffusion, and radiofrequency (RF) refocusing effects in gradient‐echo sequences.MethodsThe model was developed by integrating a forward solution of the Bloch equations with a Brownian dynamics simulator. Simulation configurations were then designed to model MR signal dynamics of interest, with a primary focus on hyperpolarized 13C MRI methods. Phantom scans and spectrophotometric assays were conducted to validate model results in vitro.ResultsThe model accurately reproduced the reaction kinetics of enzyme‐mediated conversion of pyruvate to lactate. When varying proportions of restrictive structure were added to the reaction volume, nonlinear changes in the reaction rate measured in vitro were replicated in silico. Modeling of RF refocusing effects characterized the degree of diffusion‐weighted contribution from preserved residual magnetization in nonspoiled gradient‐echo sequences.ConclusionsThese results show accurate reproduction of a range of MR signal mechanisms, establishing the model's capability to investigate the multifactorial signal dynamics such as those underlying hyperpolarized 13C MRI data.
Training potential of a teleoperated humanoid robot for use by a young psychiatrist during childcare leave
Authors: Kawahara Hiroko , Kanchi Nobukazu , Kawata Megumi , Yoshikawa Yuichiro , Baba Jun , Muramatsu Taro , Ishiguro Hiroshi , Kumazaki Hirokazu 
Published: September 2024

AbstractBackgroundChildcare leave extensions can sometimes negatively affect the professional clinical training of early‐career psychiatrists in Japan. During childcare leave, being able to learn in the examination room while staying at home would be useful. Therefore, we developed a training system using a teleoperated robot (Sota) for young psychiatrists who wanted to participate in the examination room during childcare leave while remaining at home.Case PresentationWe report the case of a patient with autism spectrum disorder (ASD) comorbid with Tourette's disorders (P). A young female psychiatrist (D) used the training system to learn from a board‐certified psychiatrist. In this case, the board‐certified psychiatrist, P, and the robot were placed in the examination room. D teleoperated Sota from home, allowing her to talk to the board‐certified psychiatrist and P. She learned about the clinical features of Tourette's syndrome by observing the examination of the board‐certified psychiatrist and hearing the patient's distress. P was satisfied with the fact that he was seen not only by a board‐certified psychiatrist but also by D.ConclusionThese case findings suggest that our system is helpful for young psychiatrists who want to study in the examination room during childcare leave while staying at home. Future studies should include a single‐case experimental design with information regarding key outcome variables and other relevant variables gathered regularly over time.
Comparative evaluation of vat photopolymerization and steel tool molds on the performance of injection molded and overmolded tensile specimens
Authors: Jian Xun , Gong Ke , Moritz Vicente , Portela Alexandre , Lu Yinshi , Du Wenyi , Major Ian 
Published: September 2024

AbstractThis study explores the use of vat polymerization stereolithography (SLA) for fabricating mold tooling, subsequently utilized in injection molding (IM) and overmolding of tensile specimens and directly compared to those produced using metal molds. The results first find the manufacturing time for an SLA‐fabricated mold is remarkably short, approximately 6 h, presenting a substantial improvement over traditional methods. Mechanical testing revealed that the tensile specimens from the SLA‐fabricated molds exhibited the highest tensile strength among all overmolding batches. This performance was consistent with the tensile bars produced using metal molds, demonstrating the viability of SLA‐fabricated molds for overmolding applications and highlighting the potential of FDM to customize the properties of final products. However, variations in mold types impacted the dimensional tolerance and tensile strength of the final specimens. Metal mold‐fabricated tensile bars exhibited superior dimensional accuracy and maximum tensile strength (50.6–61.7 MPa) compared to those produced with SLA‐fabricated molds (46.9–55.9 MPa). These differences are attributed to the rougher surface finish inherent to the layer‐by‐layer construction of SLA and the internal stresses and defects resulting from lower thermal conductivity and uneven cooling. In conclusion, this study underscores the promising future applications of SLA‐fabricated molds in overmolding, offering reduced manufacturing costs and enhanced design freedom. The findings support the potential of SLA to revolutionize mold fabrication, thereby extending its utility and optimizing the production of polymer components with customized properties.Highlights
SLA molds compared to metal molds for direct injection molding and overmolding.
FFF preforms with varied geometries were overmolded to finalize the specimens.
Joint configurations in overmolding improved tensile performance.
Overmolding showed better dimensional accuracy than FFF specimens.
SLA mold preparation significantly reduced manufacturing costs.
Application of wet carbon black masterbatch in green mining radial tires
Authors: Luo Kangyu , Wang Zifeng , Yong Zhanfu 
Published: September 2024

AbstractIn the context of environmental protection and energy consumption reduction, reducing the rolling resistance of mining machinery tires is one of the important methods to achieve the goal of green mining. This study probes the effects of wet mixing with a wet carbon black masterbatch on the rolling resistance and grounding performance of wide‐body vehicle tire treads by investigating the cross‐linking structure, rubber–filler (R–F) interaction force, and physicomechanical properties of the wet mixing rubber compounded with a wet carbon black masterbatch. The results indicate decreases in the maximum torque‐minimum torque difference, cross‐link density, and R–F interaction of the wet mixing rubber and increased filler–filler (F–F) interaction and carbon black dispersion. Meanwhile, the tensile elongation of the wet mixing rubber increases, its DIN abrasion property improves, and its Tanδ decreases at 60°C. A numerical method to estimate tire steady‐state rolling resistance is also developed. Finite element simulation analysis reveals that the steady‐state rolling resistance of the wet mixing rubber is reduced by 7.04% at 100% standard load, and its grounding performance is enhanced. By proposing a method to reduce the rolling resistance of tires, this study also provides a reference for the development of wide‐body vehicle tires.Highlights
Explored the filler interaction of wet mixing rubber.
Explained the low energy loss of wet mixing rubber.
Proposed a new finite element method for calculating tire rolling resistance.
Effects of graphene oxide and silane‐grafted graphene oxide on chitosan packaging nanocomposite films for bread preservation
Authors: Eskitoros‐Togay Ş. Melda 
Published: September 2024

AbstractThis study aims to investigate the dual effects of (3‐aminopropyl)triethoxysilane (APTES)‐grafted‐GO (A‐g‐GO), and titanium dioxide (TiO2) on the novel chitosan (CS) packaging nanocomposite films developed via the solution‐casting method. The chemical properties of GO and A‐g‐GO were assessed using FTIR and XRD. Subsequently, the chemical, structural, and physical attributes of all chitosan packaging nanocomposite films were analyzed through FTIR, XRD, TGA, DSC, AFM, water contact angle analysis, and food packaging tests. Successful silanization of GO by APTES was first confirmed. The highest surface roughness value was observed in the CS/A‐g‐GO/TiO2 film (16.574 nm) compared to pristine CS and other nanocomposite films. Incorporating GO into the CS matrix improved its thermal stability, suggesting robust bonding between GO and the polymer matrix. The addition of A‐g‐GO slightly decreased the contact angle value (107.7° for CS/A‐g‐GO), whereas TiO2 increased contact angles (117.3° for CS/GO/TiO2 and 119.4° for CS/A‐g‐GO/TiO2), suggesting a more hydrophilic structure with GO and A‐g‐GO and a more hydrophobic structure with TiO2. Bread samples showed no structural distortion over 40 days. Therefore, the dual impacts of A‐g‐GO and TiO2 on the pristine CS film imply that the resulting CS/A‐g‐GO/TiO2 film exhibits potential as an exceptionally efficient packaging material for prolonging the freshness of bread.
Surgical treatment of lung cancer associated with Werner's syndrome: A case report and review of the literature
Authors: Ishibashi Fumihiro , Horio Joji , Tachibana Kaori , Terada Jiro , Shibuya Kiyoshi 
Published: September 2024

AbstractWerner's syndrome is a rare progressive disorder that is characterized by a variety of clinical manifestations which mimic features of advanced ageing. Malignancy is one of the most problematic complications of Werner's syndrome. Lung cancer associated with Werner's syndrome is rare. A 54‐year‐old woman with Werner's syndrome was referred to our department because an abnormal shadow had been detected on routine chest radiography. Chest computed tomography revealed an abnormal nodule in the left upper lobe. Bronchoscopic examination revealed the presence of squamous cell carcinoma. Other imaging studies showed no metastatic lesions; therefore, the patient was diagnosed with stage IA3 squamous cell carcinoma. She underwent left upper lobectomy and lymph node dissection without major complications, and no recurrence was found for 2 years postoperatively.
Eosinophilic reactive airways disease after immune checkpoint inhibitor treatment
Authors: Cordial Parker , Bentley Ian D. , Horowitz Jeffrey C. , Ho Kevin 
Published: September 2024

AbstractImmune checkpoint inhibitors (ICI) are increasingly utilized as first‐line treatment for many solid tumour malignancies. One downside of ICI therapy is autoimmune‐mediated organ inflammation, or immune‐related adverse events (irAE). ICI‐related pneumonitis, or non‐infectious inflammation of the lung, is a well‐described irAE. While guidelines surrounding ICI‐related pneumonitis are well established, other ICI‐related pulmonary toxicities, including reactive airways disease, are rarely described in the literature. Here, we present a series of patients without pre‐existing COPD or asthma who developed reactive airways disease with peripheral eosinophilia after ICI therapy and without radiographic evidence of pneumonitis. The patients were treated with typical therapies for reactive airways disease, including– inhaled steroids, bronchodilators, systemic steroids, and in one instance, dupilumab. All experienced symptomatic improvement with these therapies, enabling some of the patients to continue receiving ICI therapy.
Localized data‐driven consensus control for continuous‐time multi‐agent systems
Authors: Chang Zeze , Li Zhongkui 
Published: September 2024

AbstractThis article proposes a localized data‐driven consensus framework for leader‐follower multi‐agent systems with unknown continuous‐time agent dynamics for both noiseless and noisy data scenarios. In this setting, each follower calculates its feedback control gain based on its locally sampled data, including the states, state derivatives, and inputs. We propose novel distributed control protocols that synchronize the distinct dynamic feedback gains and achieve leader‐follower consensus. Design methods are provided for the devised data‐based consensus control algorithms, which rely on low‐dimensional linear matrix inequalities. The validity of the developed algorithms is demonstrated via simulation examples.
High Photocytotoxicity Iridium(III) Complex Photosensitizer for Photodynamic Therapy Induces Antitumor Effect Through GPX4‐Dependent Ferroptosis
Authors: Zhang Qing , Chen Dezhi , Liu Xiaomeng , Deng Zhewen , Li Jiaqi , Zhu Senqiang , Ma Bo , Liu Rui , Zhu Hongjun 
Published: September 2024

AbstractThe development of small molecule photosensitizers based on iridium complex is limited by the mismatch between therapeutic effect and systemic toxicity, as well as the incomplete understanding of the molecular mechanism underlying cell death induction. Herein, a small molecule iridium complex IrC with high photocytotoxicity is synthesized, with half maximal inhibitory concentration as low as 91 nm, demonstrating excellent anti‐tumor, relief of splenomegaly, and negligible side effects. Starting from the factors of effective photosensitizers, the in‐depth theoretical analysis on photon absorption efficiency, energy transfer level matching, and properties of the triplet excited state of IrC is conducted. This also elucidates the feasibility of generating the high singlet oxygen quantum yield. In addition, the death mechanism induced by IrC is focused, innovatively utilizing GPX4‐overexpression and GPX4‐knockout cells via CRISPR/Cas9 technique to comprehensively verify ferroptosis and its further molecular mechanism. The generation of ROS mediated by IrC, along with the direct inhibition of GPX4 and glutathione, synergistically increased cellular oxidative stress and the level of lipid peroxidation. This study provides an effective approach for small molecule complexes to induce GPX4‐dependent ferroptosis at low‐dose photodynamic therapy.
True Random Number Generator Based on Chaotic Oscillation of a Tunable Double‐Well MEMS Resonator
Authors: Wu Junhui , Sun Haoyang , Zhou Guangya 
Published: September 2024

AbstractChaotic systems have aroused interest across various scientific disciplines such as physics, biology, chemistry, and meteorology. The deterministic but unpredictable nature of a chaotic system is an ideal feature for random number generation. Microelectromechanical systems (MEMS) are a promising technology that effectively harnesses chaos, offering advantages such as a compact footprint, scalability, and low power consumption. This paper presents a true random number generator (TRNG) based on a double‐well MEMS resonator integrated with an actuator and position sensor. The potential energy landscape of the proposed MEMS resonator is actively tunable with a direct current voltage. Experimental demonstrations of tunable bistability and chaotic resonance are reported in this paper. A chaotic time sequence is generated through piezoresistive sensing of the position of the MEMS resonator once it is driven into the chaotic regime. Subsequently, the randomness of the bit sequence, achieved by applying the exclusive or function to a digital chaotic sequence and its delayed differential is confirmed to meet the National Institute of Standards and Technology specifications. Moreover, the throughput and energy efficiency of the proposed MEMS‐based TRNG can be adjusted from 50 kb s–1 and 0.44 pJ per bit at a low energy barrier to 167 kb s–1 and 6.74 pJ per bit at a high energy barrier by changing the MEMS device's potential well. The tunability of the proposed double‐well MEMS resonator not only offers continuous adjustments in the energy efficiency of TNRG but also unveils vast and diverse research opportunities in analog computing, encryption, and secure communications.
In Situ Inorganic/Organic Protective Layer on Carbon Paper as Advanced Current Collector for Robust Li Metal Anode
Authors: Li Youpeng , Duan Haofan , He Shuqin , Li Junxian , Hu Yang , Li YuTing , Wu Shijie , Wu Heng , Xu Guobao , Wang Gang 
Published: September 2024

AbstractLithium (Li) metal is regarded as the most promising anode for next‐generation batteries with high energy density. However, the uncontrolled dendrite growth and infinite volume expansion during cycling seriously hinder the application of Li metal batteries (LMBs). Herein, an inorganic/organic protective layer (labeled as BPH), composed of in situ formed inorganic constituents and PVDF‐HFP, is designed on the 3D carbon paper (CP) surface by hot‐dipping method. The BPH layer can effectively improve the mechanical strength and ionic conductivity of the SEI layer, which is beneficial to expedite the Li‐ion transfer of the entire framework and achieve stable Li plating/stripping behavior. As a result, the modified 3D CP (BPH‐CP) exhibits an ultrahigh average Coulombic efficiency (CE) of ≈99.7% over 400 cycles. Further, the Li||LiFePO4 (LFP) cell exhibits an extremely long‐term cycle life of over 3000 cycles at 5 C. Importantly, the full cell with high mass loading LiFePO4 (20 mg cm−2) or LiNi0.8Co0.1Mn0.1O2 (NCM, 16 mg cm−2) cathode exhibits stable cycling for 100 or 150 cycles at 0.5 C with high‐capacity retention of 86.5% or 82.0% even at extremely low N/P ratio of 0.88 or 0.94. believe that this work enlightens a simple and effective strategy for the application of high‐energy‐density and high‐rate‐C LMBs.
Electrostatically Self‐Assembled Magnetic Nanoparticles for High‐Temperature Resistant and Friction‐Controlled Lubrication System
Authors: Yang Tao , Wang Xiaozhen , Liu Huanchen , Chen Siwei , Liu Junming , Zhao Qin , Gong Kuiliang , Li Weimin , Liang Yongmin , Wang Xiaobo 
Published: September 2024

AbstractMagnetic‐responsive surfactants are considered promising smart lubricating materials due to their significant stimulation response to applied magnetic fields. In this study, four magneto‐responsive surfactants are successfully fabricated and encapsulated on the surface of molybdenum disulfide nanosheets (MoS2@C18H37N+(CH3)3[XCl3Br]−, X = Fe, Ce, Gd, and Ho) as base‐oil components using electrostatic self‐assembly, thereby constructing a multi‐functional magnetic lubrication system (MoS2@STAX). Magnetorheological measurements confirm the remarkable responsiveness of MoS2@STACe lubricants at high shear rates and applied magnetic fields, which is further corroborated by the constant proximity of the magnet. The formation of dense carbon and tribo‐chemical films between the friction interfaces at elevated temperatures is the primary factor contributing to the significant reduction in frictional wear. Notably, the magnetic lubricant demonstrates a pronounced response behavior when subjected to an applied magnetic field in the ceramic tribopair, even at lower magnetic fields. This work presents concepts for the development of high‐temperature resistant and tunable lubrication additives by designing the material structure and controlling the magnetic stimulation.
Origin of Enhanced Photoelectrochemical Activity of the n‐CdS/p‐type Semiconductor Interface: Homojunction or Heterojunction?
Authors: Chae Sang Youn , Jun Minki , Yoon Noyoung , Joo Oh Shim , Kim Jin Young , Park Eun Duck 
Published: September 2024

AbstractSurface engineering of photoelectrodes is considered critical for achieving efficient photoelectrochemical (PEC) cells, and various p‐type materials have been investigated for use as photoelectrodes. Among these, the p‐type semiconductor/n‐type CdS heterojunction is the most successful photocathode structure because of its enhanced onset potential and photocurrent. However, it is determined that the main contributor to the enhanced activity is the Cd‐doped layer and not the CdS layer. In this study, a Cd‐doped n+p‐buried homojunction of a CuInS2 photocathode is first demonstrated without a CdS layer. The homojunction exhibited a more active and stable PEC performance than the CdS/CuInS2 heterojunction. Moreover, it is confirmed that Cd doping is effective for other p‐type materials. These results strongly suggest that the effects of Cd doping on photocathodes should be carefully investigated when designing CdS/p‐semiconductor heterojunction photoelectrodes. They also indicate that the Cd‐doped layer has great potential to replace the CdS layer in future photoelectrode designs.
Spatially Confined Alloying of Pt Accelerates Mass Transport for Fuel Cell Oxygen Reduction
Authors: Gao Yuxin , Liu Hang , Wang Xintian , Liu Xiao , Shan Bin , Chen Rong 
Published: September 2024

AbstractPt‐based alloy with high mass activity and durability is highly desired for proton exchange membrane fuel cells, yet a great challenge remains due to the high mass transport resistance near catalysts with lowering Pt loading. Herein, an extensible approach employing atomic layer deposition to accurately introduce a gas‐phase metal precursor into platinum nanoparticles (NPs) pre‐filled mesoporous channels is reported, achieved by controlling both the deposition site and quantity. Following the spatially confined alloying treatment, the prepared PtSn alloy catalyst within mesopores demonstrates a small size and homogeneous distribution (2.10 ± 0.53 nm). The membrane electrode assembly with mesoporous carbon‐supported PtSn alloy catalyst achieves a high initial mass activity of 0.85 A at 0.9 V, which is attributed to the smallest local oxygen transport resistance (3.68 S m−1) ever reported. The mass activity of the catalyst only decreases by 11% after 30000 cycles of accelerated durability test, representing superior full‐cell durability among the reported Pt‐based alloy catalysts. The enhanced activity and durability are attributed to the decreased adsorption energy of oxygen intermediates on Pt surface and the strong electronic interaction between Pt and Sn inhibiting Pt dissolution.