bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACTN3 Genotype in Professional Sport Climbers
Authors: Ginszt Michał , Michalak-Wojnowska Małgorzata , Gawda Piotr , Wojcierowska-Litwin Magdalena , Korszeń-Pilecka Iwona , Kusztelak Małgorzata , Muda Rafał , Filip Agata A. , Majcher Piotr 
Published: February 2018

Abstract
Ginszt, M, Michalak-Wojnowska, M, Gawda, P, Wojcierowska-Litwin, M, Korszeń-Pilecka, I, Kusztelak, M, Muda, R, Filip, AA, and Majcher, P. ACTN3 genotype in professional sport climbers. J Strength Cond Res 32(5): 1311–1315, 2018—The functional RR genotype of the alpha-actinin-3 (ACTN3) gene has been reported to be associated with elite sprint/power athlete status. Although large and rapidly increasing number of studies have investigated the associations between the ACTN3 genotypes and athletic performance in various sport disciplines, there is a lack of studies on the genetic predisposition in sport climbing, which was selected to be part of the next Summer Olympic Games in Tokyo 2020 with three subdisciplines (“lead climbing,” “speed climbing,” and “bouldering”). The aim of the study is to determine the frequency distribution of ACTN3 genotypes and alleles in professional lead climbers and boulderers. 100 professional sport climbers from Poland, Russia, and Austria were divided into 2 equal groups: professional boulderers and professional lead climbers were involved in the study. ACTN3 allele frequencies and genotypes were compared with 100 sedentary controls. Genotypes were determined using polymerase chain reaction–restriction fragment length polymorphism method. The percent distribution of RR genotype in the boulderers was significantly higher than in lead climbers and controls (62 vs. 26%; 33%, respectively; χ2 = 17.230, p = 0.0017). The frequencies of ACTN3 R allele in boulderers differed significantly from lead climbers and controls (77 vs. 51%; 58%, respectively; χ2 = 15.721, p = 0.0004). The proportion of the ACTN3 RR genotype is significantly higher in boulderers than in lead climbers and may be related to the specific type of predisposition to this subdiscipline.
Examination of a Multi-ingredient Preworkout Supplement on Total Volume of Resistance Exercise and Subsequent Strength and Power Performance
Authors: Bergstrom Haley C. , Byrd M. Travis , Wallace Brian J. , Clasey Jody L. 
Published: February 2018

Abstract
Bergstrom, HC, Byrd, MT, Wallace, BJ, and Clasey, JL. Examination of a multi-ingredient preworkout supplement on total volume of resistance exercise and subsequent strength and power performance. J Strength Cond Res 32(6): 1479–1490, 2018—This study examined the acute effects of a multi-ingredient preworkout supplement on (a) total-, lower-, and upper-body volume of resistance exercise and (b) the subsequent lower-body strength (isokinetic leg extension and flexion), lower-body power (vertical jump [VJ] height), upper-body power (bench throw velocity [BTv]), and cycle ergometry performance (critical power and anaerobic work capacity). Twelve men completed baseline strength and power measures before 2 experimental visits, supplement (SUP) and placebo (PL). The experimental visits involved a fatiguing cycling protocol 30 minutes after ingestion of the SUP or PL and 15 minutes before the beginning of the resistance exercise protocol, which consisted of 4 upper-body and 4 lower-body resistance exercises performed for 4 sets to failure at 75% 1 repetition maximum. The exercise volume for the total, lower, and upper body was assessed. The VJ height and BTv were measured immediately after the resistance exercise. Postexercise isokinetic leg extension and flexion strength was measured 15 minutes after the completion of a second cycling protocol. There was a 9% increase in the total-body volume of exercise and a 14% increase in lower-body volume of exercise for the SUP compared with the PL, with no effect on exercise volume for the upper body between the SUP and PL. The increased lower-body volume for the SUP did not result in greater lower-body strength and power performance decrements after exhaustive exercise, compared with the PL. These findings suggested the potential for the SUP to increase resistance exercise volume, primarily related to an increased lower-body volume of exercise.
Effects of Different Plyometric Training Frequencies on Measures of Athletic Performance in Prepuberal Male Soccer Players
Authors: Bouguezzi Raja , Chaabene Helmi , Negra Yassine , Ramirez-Campillo Rodrigo , Jlalia Zied , Mkaouer Bessem , Hachana Younés 
Published: February 2018

Abstract
Bouguezzi, R, Chaabene, H, Negra, Y, Ramirez-Campillo, R, Jlalia, Z, Mkaouer, B, and Hachana, Y. Effects of different plyometric training frequencies on measures of athletic performance in prepuberal male soccer players. J Strength Cond Res 34(6): 1609–1617, 2020—This study aimed to compare the effects of 1 vs. 2 sessions of equal-weekly volume plyometric training (PT) across 8 weeks on measures of athletic performance (i.e., sprint time, change of direction [CoD], jumping ability, and muscle strength) in prepuberal male soccer players. Thirty participants were randomly assigned either to 1 session PT group (1SPT [n = 15]) or 2 sessions PT group (2SPT [n = 15]). Plyometric training was integrated into their regular soccer training routine. Pretraining and posttraining tests for the assessment of sprint time (e.g., 5, 10, 20, and 30-m), CoD (e.g., T-test and modified Illinois change of direction test [MICODT]), jumping ability (e.g., standing long jump [SLJ], countermovement jump [CMJ], and squat jump [SJ]), muscle strength (reactive strength index [RSI]), and kicking distance were conducted. Results showed a main effect of time for 5-m sprint-time performance (F
(1,56) = 4.00, effect size [ES] = 0.53 [medium], p = 0.05), T-test (F
(1,56) = 23.19, ES = 1.28 [large], p < 0.001), MICODT (F
(1,56) = 5.72, ES = 0.94 [large], p = 0.02), SLJ (F
(1,56) = 16.63, ES = 1.09 [large], p < 0.001), CMJ (F
(1,56) = 15.43, ES = 1.04 [large], p < 0.001), SJ (F
(1,56) = 20.27, ES = 1.20 [large], p < 0.001), RSI (F
(1,56) = 26.26, ES = 1.36 [large], p < 0.001), and kicking distance (F
(1,56) = 47.19, ES = 1.83 [large], p < 0.001). There were no training group × time interactions in all the measured outcomes. In conclusion, when an equated moderate volume of jumps is performed, higher PT frequency across 8 weeks has no extra effects on prepuberal male soccer players' measures of athletic performance. The present findings may help optimizing PT interventions dedicated to prepuberal male soccer players.
Effective Control Chart for Monitoring the Capability Stability of Non-Normal Processes Having S-Type Quality
Authors: Liao Mou-Yuan , Ling Hsiao-Chi 
Published: February 2018

Abstract
For processes that have an S-type quality characteristic, the index CpkuWSD provides a proper measure for process quality. In the context of the index CpkuWSD, the main purpose of this study is to construct efficient control charts via bootstrap procedures for monitoring the stability of process quality. Simulations show that these bootstrap procedures have reasonable empirical coverage probabilities. In addition, run rules are provided for decision-making.
Ketamine Alters Lateral Prefrontal Oscillations in a Rule-Based Working Memory Task
Authors: Ma Liya , Skoblenick Kevin , Johnston Kevin , Everling Stefan 
Published: February 2018

Acute administration of N-methyl-D-aspartate receptor (NMDAR) antagonists in healthy humans and animals produces working memory deficits similar to those observed in schizophrenia. However, it is unclear whether they also lead to altered low-frequency (≤60 Hz) neural oscillatory activities similar to those associated with schizophrenia during working memory processes. Here, we recorded local field potentials (LFPs) and single-unit activity from the lateral prefrontal cortex (LPFC) of three male rhesus macaque monkeys while they performed a rule-based prosaccade and antisaccade working memory task both before and after systemic injections of a subanesthetic dose (≤0.7 mg/kg) of ketamine. Accompanying working-memory impairment, ketamine enhanced the low-gamma-band (30–60 Hz) and dampened the beta-band (13–30 Hz) oscillatory activities in the LPFC during both delay periods and intertrial intervals. It also increased task-related alpha-band activities, likely reflecting compromised attention. Beta-band oscillations may be especially relevant to working memory processes because stronger beta power weakly but significantly predicted shorter saccadic reaction time. Also in beta band, ketamine reduced the performance-related oscillation as well as the rule information encoded in the spectral power. Ketamine also reduced rule information in the spike field phase consistency in almost all frequencies up to 60 Hz. Our findings support NMDAR antagonists in nonhuman primates as a meaningful model for altered neural oscillations and synchrony, which reflect a disorganized network underlying the working memory deficits in schizophrenia.SIGNIFICANCE STATEMENTLow doses of ketamine, an NMDAR blocker, produce working memory deficits similar to those observed in schizophrenia. In the lateral prefrontal cortex, a key brain region for working memory, we found that ketamine altered neural oscillatory activities in similar ways that differentiate schizophrenic patients and healthy subjects during both task and nontask periods. Ketamine induced stronger gamma (30–60 Hz) and weaker beta (13–30 Hz) oscillations, reflecting local hyperactivity and reduced long-range communications. Furthermore, ketamine reduced performance-related oscillatory activities, as well as the rule information encoded in the oscillations and in the synchrony between single-cell activities and oscillations. The ketamine model helps link the molecular and cellular basis of neural oscillatory changes to the working memory deficit in schizophrenia.
Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures
Authors: Cassatella Daniele , Howard Sasha R , Acierno James S , Xu Cheng , Papadakis Georgios E , Santoni Federico A , Dwyer Andrew A , Santini Sara , Sykiotis Gerasimos P , Chambion Caroline , Meylan Jenny , Marino Laura , Favre Lucie , Li Jiankang , Liu Xuanzhu , Zhang Jianguo , Bouloux Pierre-Marc , Geyter Christian De , Paepe Anne De , Dhillo Waljit S , Ferrara Jean-Marc , Hauschild Michael , Lang-Muritano Mariarosaria , Lemke Johannes R , Flück Christa , Nemeth Attila , Phan-Hug Franziska , Pignatelli Duarte , Popovic Vera , Pekic Sandra , Quinton Richard , Szinnai Gabor , l’Allemand Dagmar , Konrad Daniel , Sharif Saba , Iyidir Özlem Turhan , Stevenson Brian J , Yang Huanming , Dunkel Leo , Pitteloud Nelly 
Published: February 2018

Objective
Congenital hypogonadotropic hypogonadism (CHH) and constitutional delay of growth and puberty (CDGP) represent rare and common forms of GnRH deficiency, respectively. Both CDGP and CHH present with delayed puberty, and the distinction between these two entities during early adolescence is challenging. More than 30 genes have been implicated in CHH, while the genetic basis of CDGP is poorly understood.

Design
We characterized and compared the genetic architectures of CHH and CDGP, to test the hypothesis of a shared genetic basis between these disorders.

Methods
Exome sequencing data were used to identify rare variants in known genes in CHH (n = 116), CDGP (n = 72) and control cohorts (n = 36 874 ExAC and n = 405 CoLaus).

Results
Mutations in at least one CHH gene were found in 51% of CHH probands, which is significantly higher than in CDGP (7%, P = 7.6 × 10−11) or controls (18%, P = 5.5 × 10−12). Similarly, oligogenicity (defined as mutations in more than one gene) was common in CHH patients (15%) relative to CDGP (1.4%, P = 0.002) and controls (2%, P = 6.4 × 10−7).

Conclusions
Our data suggest that CDGP and CHH have distinct genetic profiles, and this finding may facilitate the differential diagnosis in patients presenting with delayed puberty.
Pemodelan Matematika Infiltrasi Air pada Saluran Irigasi Alur
Authors: Manaqib Muhammad 
Published: February 2018

Water is one of the main necessity of agricultural activities, because without enough water agricultural crops will not be produced optimally. The way to insufficient water in agricultural crops is irrigation. One of the irrigation methods which is used on agriculture in the world is furrow irrigation method. Water gets into the soil from the bottom of the furrow and furrow’s wall towards the root zone of the plants. The complexity of the water infiltration process in the ground makes infiltration analysis by laboratory experiment difficult to do and needs substantial cost. The alternative way which can do is with mathematical modeling. This paper discusses about mathematical modeling of water infiltration in furrow irrigation channel trapezoidal in shape. This mathematical modeling is shaped boundary condition problem with a cross section of a closed and limited line of irrigation. Governing equation obtanined from Richard equation which then transformed using Kirchoff transformation and non dimensional variable into the modified Helmholtz equation. While, the boundary condition is shaped mixture Neuman and Robin boundary condition.
Beberapa Metode pada Masalah Pemrograman Stokastik
Authors: Hasbiyati Ihda , Hasriati Hasriati 
Published: February 2018

Stochastic programming problem is mathematical problem (linear, integer, mixed integer, and nonlinier) with stochastic element lies data. To get reasonable solution and optimal with its stochastic data is needed several method. Applicable method in trouble stochastic programming are L-Shape decomposition and lagrange decomposition. Each method can determine optimal solution to troubleshoots stochastic programming
Wpływ bazy kosmetycznej na uwalnianie kwasu usninowego
Authors: Kucia Małgorzata , Sikora Elżbieta 
Published: February 2018

Usnic acid is a type of lichen acid which exhibits a broad spectrum of biological activity, functioning as an antimicrobial, an anti-inflammatory and a UV-filter. It is used as an active ingredient in herbal medicines and cosmetics products. Its influence as a cosmetics base, including through properties such as emulsion type or degree of internal phase droplet size, on the release of usnic acid, was studied. Two types (O/W, W/O) of usnic acid – loaded, stable emulsions with varying degrees of dispersion of the dispersed phase were obtained. The concentration of usnic acid in all of the formulations studied was 0.05% w/w. The formulations’ physicochemical properties, including stability, viscosity, pH and the droplet size of the dispersed phase, were evaluated. The kinesis of the usnic acid’s release was performed in a thermostatic diffusion chamber, at a temperature of T = 32°C, using dialysis membranes of regenerated cellulose. A mixture of phosphate buffer (PBS) and ethanol (EtOH), in 90/10, PBS/EtOH, volume ratio, was used as an acceptor solution. The concentration of released usnic acid was analyzed by UV-Vis spectrophotometer. The results showed that the O/W emulsions, as compared to W/O emulsions, are a much more effective means of administering usnic acid to the skin. After 24 hours, approx. 45% of the initial acid concentration penetrated into the acceptor solution from O/W emulsion, while from the W/O emulsion the released amount was about 18%.
Zastosowanie gier symulacyjnych w kształceniu w zakresie współczesnych koncepcji zarządzania
Authors: Walczak Maciej 
Published: February 2018

The article presents the results of research into the effects of simulation games used in a university course on contemporary management concepts. Aside from a review of the literature, the article’s key findings come from a survey of 142 full-time students in academic years 2014/2015 and 2015/2016. The basic issues surrounding simulation games for education are briefly described and two games used in the study are presented in the first part of the article. The most important results of the questionnaire, along with an interpretation of them, are presented in the further sections. Recommendations on how to use simulation games in the teaching process at universities conclude the paper.
Tendinites em praticantes de musculação: estudo transversal
Authors: Santos Kleyton Trindade , Lima Leonardo da Silva , Teixeira Warlisson Santos 
Published: February 2018

INTRODUÇÃO: Exercícios com cargas vêm se mostrando eficiente na promoção de saúde e ocupando cada vez mais espaço no cenário de prática esportiva atual, porém merecem atenção em relação a ocorrência de lesões, em especial as tendinites. OBJETIVO: Avaliar a prevalência de tendinites em praticantes de musculação, divididos em três grupos, verificando os fatores de associação. MÉTODOS: Estudo transversal, descritivo e analítico, de caráter quantitativo. A amostra foi composta por 208 alunos com idade a partir de 18 anos. Foi utilizado um questionário próprio composto de dados sociodemográficos e relacionados à presença ou não de tendinites, que foi confirmada através do diagnóstico médico. Os dados foram tabulados e analisados no SPSS 15.0, sendo geradas as frequências relativas e absolutas de interesse para pesquisa. As associações entre a tendinite, o tipo de treinamento e os fatores associados foram analisadas a partir do teste do qui-quadrado ou Exato de Fischer. RESULTADOS: A prevalência de tendinite foi de 17,8% foi associada ao treino de hipertrofia, ser do sexo masculino, usar anabolizantes, suplementos e medicamentos, além de não treinar sem supervisão. CONCLUSÃO: A tendinite apresenta-se como uma lesão frequente em praticantes de musculação. Existem alguns fatores que contribuem para ocorrência dessa lesão, servindo de alerta aos profissionais de saúde a fim de minimizar essa lesão.
Fermente Süt İçeceğinde Probiyotik Bakterilerin Gelişimi Üzerine Meyve İlavesinin Etkisi
Authors: BARAT Abdullah , ÖZCAN Tülay 
Published: February 2018

&nbsp;

Bu çalışmada kontrol (K);
karadut (DFİ); siyah üzüm (ÜFİ) ve kızılcık meyveli fermente içecek (KFİ)
olmak üzere 4 farklı probiyotik fermente süt içeceği üretilmiştir. Üretimde
kullanılacak sütlere Streptococcus thermophilus, Lactobacillus delbrueckii subsp.
bulgaricus, Lactobacillus
acidophilus ve Bifidobacterium lactis içeren starter kültür
inoküle edilerek inkübasyona bırakılmıştır. Meyveli probiyotik fermente içecek
örneklerinde bulunan bileşenlerin bakterilerin gelişmesini teşvik eden
potansiyel prebiyotik&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;etkisi sonucu S. thermophilus,
Lactobacillus delbrueckii subsp.
bulgaricus, &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;L. acidophilus, &nbsp;B.
lactis sayılarının önerilen biyoterapötik
seviyede (&gt;106 log
kob mL-1) olduğu
saptanmıştır (p&lt;0.01). KFİ örneğinde toplam antioksidan kapasite değeri,
askorbik asit ve toplam fenolik bileşen değerlerinin yüksek olmasına bağlı
olarak yüksek bulunmuştur. Sonuç olarak, meyve ilaveli fermente süt
içeceklerinin probiyotik bakterilerin metabolizmaya alınması için alternatif
ürün olarak değerlendirilebileceği belirlenmiştir.

&nbsp;
Organik Etlik Piliç Karma Yemlerine İlave Edilen Yonca Ununun Karkas Özellikleri, Nispi Organ Ağırlıkları, Bağırsak Viskozitesi, İncik ve Ayak Rengi Üzerine Etkileri
Authors: TAN Kağan , KIRKPINAR Figen 
Published: February 2018

Bu çalışma organik yonca ununun yavaş gelişen organik etlik
piliçlerin karma yemlerinde kullanılmasının karkas özellikleri, nispi organ ağırlıkları,
bağırsak viskozitesi, incik ve ayak renk değeri üzerine etkilerini belirlemek
amacıyla yapılmıştır. Çalışmada, toplam 225 adet günlük yaşta erkek ve dişi karışık Hubbard Red JA etlik civciv kullanılmıştır. Civcivler canlı ağırlık (CA) farklılıkları
istatistiki olarak önemsiz olacak şekilde 3 muamele grubuna 5 tekerrürlü (n=15)
olarak dağıtılmıştır. Deneme süresince (77 gün) muamele gruplarında %0, %5 ve
%10 düzeylerinde yonca unu içeren yemler kullanılmıştır. Deneme sonunda
karkas ağırlığı, pankreas, bezel mide, taşlık, duodenum, ileum + jejenum ve
kalın bağırsak ağırlıklarında önemli farklılıklar saptanmış (P&lt;0.05),
karkas randımanı, göğüs, but, abdominal
yağ, karaciğer, kalp, dalak, pankreas, bursa fabricius ve kör bağırsak nispi
ağırlıkları ve bağırsak viskozitesi ise değişmemiştir (P&gt;0.05). Yonca unu
ilavesi incik parlaklık ve sarı rengi ile ayak sarı rengini etkilemezken
(P&gt;0.05), incik kırmızılık değeri ile ayak parlaklık ve kırmızılık değerini
(%5 yonca grubunda) artırmıştır (P&lt;0.05). Organik üretimde kanatlı kümes
hayvanlarının beslenmesinde gerek yem karmasının içinde gerekse gezinme
alanında yararlanılacak kaba yemlerin etkilerinin incelenmesi ve uygun
düzeylerinin saptanması için bu konuda yapılacak araştırmalara ihtiyaç
duyulmaktadır.
Pendidikan Keluarga Seimbang yang Melekat Sebagai Basis yang Mencerahkan Anak di Era Digital
Authors: Rahmatullah Azam Syukur 
Published: February 2018

The degree of behavioral deviation done by children in the present era is increasingly apprehensive, especially in the digital era which anything seems sophisticated resulting children are "spoiled and pampered" by technological prowess. This is what is called a "digital trap”, and one of the things that makes it easy for children to get into the trap is due to the "Split Personality" between a child and a parent. In the absence of pure relation and attachment between a child and a parent, consequently, the parent's obligation to the child is not fulfilled, one of which is a sincere accompaniment to a child when she or he explores the virtual world through digital media. Therefore, it becomes important that balanced family education is inherent with the child in the home, so that parents more easily lead the child into the positive way while browsing the virtual world through digital media. The parenting patternsought to beapplied based on a strong godliness, open and not manipulative.إن نسبة انحراف السلوكيات التي قام بها الأطفال في هذا العصر يثير المخاوف. وخاصة في هذا العصر (العصر الرقمي) بما فيه من الأشياء الراقية، جعل الأولاد مُدلّلين فيه بتقدم التقنية. وهذا هو المسمّى بالفخاخ الرقمي، وأحد الأسباب في سهولة الأطفال للدخول في الفخاخ الرقمي هو وجود انفصام الشخصية بين الأولاد والوالدين. وبعدم القرب الخالص بين الأولاد والوالدين لا يستقيم أداء واجبات الوالدين تجاه الأولاد، ومنها مصاحبة خالصة نحو الأبناء حين غاصوا في الفضاء الإلكتروني عن طريق الجهاز الرقمي، لذا فإن التربية الأسرية المتّزنة مهمة للأولاد في البيت، ليسهل للآباء توجيه الأولاد إلى الطريق السويّ الإيجابيّ طوال غوص هؤلاء في الفضاء الإلكتروني. وأسلوب تحضين الأولاد الذي يمكن للوالدين اتّخاذه هو الأسلوب القويّ المؤسّس على الدين، والمتفتّح ولا خداع فيه.