bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of ossification-related miRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis
Authors: Takahashi Kan , Satoh Mamoru , Takahashi Yuji , Osaki Takuya , Nasu Takahito , Tamada Makiko , Okabayashi Hitoshi , Nakamura Motoyuki , Morino Yoshihiro 
Published: April 2016

CAVD (calcific aortic valve disease) is the defining feature of AS (aortic stenosis). The present study aimed to determine whether expression of ossification-related miRNAs is related to differentiation intro COPCs (circulating osteogenic progenitor cells) in patients with CAVD. The present study included 46 patients with AS and 46 controls. Twenty-nine patients underwent surgical AVR (aortic valve replacement) and 17 underwent TAVI (transcatheter aortic valve implantation). The number of COPCs was higher in the AS group than in the controls (P&lt;0.01). Levels of miR-30c were higher in the AS group than in the controls (P&lt;0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P&lt;0.01). The number of COPCs and levels of osteocalcin protein in COPCs were positively correlated with levels of miR-30a and negatively correlated with levels of the remaining miRNAs (all P&lt;0.05). The degree of aortic valve calcification was weakly positively correlated with the number of COPCs and miR-30c levels. The number of COPCs and miR-30c levels were decreased after surgery, whereas levels of the remaining miRNAs were increased (all P&lt;0.05). Changes in these levels were greater after AVR than after TAVI (all P&lt;0.05). In vitro study using cultured peripheral blood mononuclear cells transfected with each ossification-related miRNA showed that these miRNAs controlled levels of osteocalcin protein. In conclusion, dysregulation of ossification-related miRNAs may be related to the differentiation into COPCs and may play a significant role in the pathogenesis of CAVD.
La chirurgie des cas de classe II et ses répercussions sur les
articulations temporo-mandibulaires
Authors: Manière-Ezvan Armelle , Savoldelli Charles , Busson Floriant , Oueiss Arlette , Orthlieb Jean-Daniel 
Published: April 2016

Traditionnellement, ces interventions visent à corriger les décalages à responsabilité
mandibulaire par une avancée de la portion dentée de la mandibule après ostéotomie
mandibulaire. Au cours de la mise en place des plaques d’ostéosynthèses se décide la
position des condyles, déjà plus reculés de par la position allongée et l’atonie
musculaire du patient curarisé. Toutes les études montrent que la chirurgie « d’avancée
mandibulaire » entraîne un mouvement latéral et un recul des condyles, ainsi qu’un
mouvement de torque, tous préjudiciables aux condyles. Les facteurs prédisposant aux
atteintes dégénératives sont « le patient » : femme (entre 15 et 40 ans) hyperdivergente
ayant des antécédents de dysfonctionnement de l’appareil manducateur (DAM) et le geste
chirurgical de par la surcharge appliquée aux condyles. Quelles sont les solutions
possibles pour éviter les échecs ? Bien préparer le patient avant la chirurgie et effectuer
une simulation (sur articulateur), maîtriser la position du condyle pendant la chirurgie,
travailler avec les chirurgiens à la réalisation de système de stabilisation de la portion
condylienne (avec l’aide de la CAO), mettre en place rapidement une mobilisation de la
mandibule par kinésithérapie.
Memory for temporally dynamic scenes
Authors: Ferguson Ryan , Homa Donald , Ellis Derek 
Published: April 2016

Recognition memory was investigated for individual frames extracted from temporally continuous, visually rich film segments of 5–15 min. Participants viewed a short clip from a film in either a coherent or a jumbled order, followed by a recognition test of studied frames. Foils came either from an earlier or a later part of the film (Experiment 1) or from deleted segments selected from random cuts of varying duration (0.5 to 30 s) within the film itself (Experiment 2). When the foils came from an earlier or later part of the film (Experiment 1), recognition was excellent, with the hit rate far exceeding the false-alarm rate (.78 vs. 18). In Experiment 2, recognition was far worse, with the hit rate (.76) exceeding the false-alarm rate only for foils drawn from the longest cuts (15 and 30 s) and matching the false-alarm rate for the 5 s segments. When the foils were drawn from the briefest cuts (0.5 and 1.0 s), the false-alarm rate exceeded the hit rate. Unexpectedly, jumbling had no effect on recognition in either experiment. These results are consistent with the view that memory for complex visually temporal events is excellent, with the integrity unperturbed by disruption of the global structure of the visual stream. Disruption of memory was observed only when foils were drawn from embedded segments of duration less than 5 s, an outcome consistent with the view that memory at these shortest durations are consolidated with expectations drawn from the previous stream.
Neural-network-based containment control of nonlinear multi-agent systems under communication constraints
Authors: Ma Chao 
Published: April 2016

Purpose
The purpose of this paper is to investigate the neural-network-based containment control of multi-agent systems with unknown nonlinear dynamics. Moreover, communication constraints are taken into account to reflect more realistic communication networks.

Design/methodology/approach
Based on the approximation property of the radial basis function neural networks, the control protocol for each agent is designed, where all the information is exchanged in the form of sampled data instead of ideal continuous-time communications.

Findings
By utilizing the Lyapunov stability theory and the Lyapunov–Krasovskii functional approach, sufficient conditions are developed to guarantee that all the followers can converge to the convex hull spanned by the stationary leaders.

Originality/value
As ideal continuous-time communications of the multi-agent systems are very difficult or even unavailable to achieve, the neural-network-based containment control of nonlinear multi-agent systems is solved under communication constraints. More precisely, sampled-data information is exchanged, which is more applicable and practical in the real-world applications.
Bio-inspired kinematical control of redundant robotic manipulators
Authors: Leylavi Shoushtari Ali , Mazzoleni Stefano , Dario Paolo 
Published: April 2016

Purpose
This paper aims to propose an innovative kinematic control algorithm for redundant robotic manipulators. The algorithm takes advantage of a bio-inspired approach.

Design/methodology/approach
A simplified two-degree-of-freedom model is presented to handle kinematic redundancy in the x-y plane; an extension to three-dimensional tracking tasks is presented as well. A set of sample trajectories was used to evaluate the performances of the proposed algorithm.

Findings
The results from the simulations confirm the continuity and accuracy of generated joint profiles for given end-effector trajectories as well as algorithm robustness, singularity and self-collision avoidance.

Originality/value
This paper shows how to control a redundant robotic arm by applying human upper arm-inspired concept of inter-joint dependency.
Factors influence students' choice of accounting major in Cambodian universities
Authors: Tang Lim Chhoung , Seng Cheaseth 
Published: April 2016

Purpose
The recent significant economic growth and development in Cambodia has created a growing demand for qualified and professional accountants. Despite such demand, there are still inadequate number of students enrolling in accounting major, which lefts the National Accounting Council (NAC), Kampucha Institute of Certified Public Accountants and Auditors (KICPAA), and academic institutions with question on how to develop strategies and plans for attracting students and in turn meeting the level required. This paper attempts to determine factors that influence Cambodian business students’ decision to choose accounting as a major for their tertiary education.

Design/methodology/approach
The paper hypothesizes that Guidance, Career Expectation, Perception, Personal Characteristic as factors that would influence students selection of accounting study. With a sample size of 240 business students, Turkey HSD Post Hoc Test and logistic regression methods are employed to ascertain the influential factors.

Findings
The results from ANOVA Turkey HSD Post Hoc Test showed that there is a statistically significant difference among universities with respect to Guidance, Career Expectation, and Personal Characteristic factor, but no significant difference was found among universities in terms of Perception factor. The logistic regression result indicated that students’ choice of accounting major has a positive and significant relationship with Guidance, Personal Characteristic factor, and age. Conversely, the results demonstrated that choice of accounting major has a negative but significant relationship with Career Expectation factor, and a negative but insignificant relationship with Perception factor. Finally, the results revealed a positive but insignificant relationship between accounting major and individual gender.

Originality/value
This paper contributes to the limited study on accounting education in Cambodia. Furthermore, it provides insights for the NAC and KICPAA and universities in Cambodia to develop strategies and plans to create a balance market of professional accountants.
Do Chinese dairy firms have market power? an estimation of market power with price heterogeneity
Authors: Guo Qing , Wang H. Holly , Chen Yongjun 
Published: April 2016

Purpose
The purpose of this paper is to investigate market power in dairy industry in China. Specifically, we analyze market power for different firm size, locations of region and city empirically.

Design/methodology/approach
We estimate the market power by controlling the unobserved price heterogeneity. The econometric model was developed through a typical production function. We added three dummy variables to differentiate firms of different sizes, at urban or rural locations, and in east or other regions, according to the characteristics of the dairy industry. A sample including 511 observations were used to do the regression.

Findings
Our results show that Chinese dairy industry as a whole is a competitive industry in general，while the large firms have gained considerable market power. The firms locate in the eastern area grow slower than firms locate in the middle and western area.

Originality/value
The authors believe that this is the first study to analyze the market power in China’s dairy industry by controlling the unobserved price heterogeneity. Dairy is usually thought to be competitive, while in our paper we found that large firms can exercise market power while small firms operate in a competitive market.
Drivers of household entry and intensity in land rental market in rural China: evidence from North Henan Province
Authors: Yan Xiaohuan , HUO XUEXI 
Published: April 2016

Purpose
Economic reforms in rural China have led to the emergence of land and labor markets. The development of rural land rental markets can improve agricultural productivity and equity by facilitating transfers of land to more productive farmers and facilitating the participation in the non-farm economy of less productive farmers. In contrast to the burgeoning development of off-farm labor markets, the development of rural land rental market has lagged. The purpose of this study is to analyze the factors affecting households’ entry and transaction intensity in rural land rental markets, especially the effects of land tenure and off-farm employment.

Design/methodology/approach
Based on a field survey data of 479 household in Henan Province in 2009, the authors used Cragg’s double hurdle model to identify the determinants for households’ land rental participation and its transaction amount.

Findings
Off-farm employment is one of main driving factor for household’s land rent-out decision. Tenure insecurity reduces both the propensity and the magnitude of rental market transactions. Land use certificates significantly contribute to participation in land-rental markets and the rental amount.

Originality/value
This paper treats household land rental market participation as a related two-step process, focusing on both land transfer and its transaction amount. This paper also builds on a broad view, including analysis on both demand and supply side of land rental market.
Trade margins, quality upgrading, and China’s agri-food export growth
Authors: Tian Dongwen , Hu Na , Wang Xin , Huang Li 
Published: April 2016

Purpose
The purpose of this paper is to find out the source and pattern of China’s agri-food export growth mainly along the intensive margin and the factors affecting it, especially the determinants contributing most to sustainable export growth.

Design/methodology/approach
The paper phases in three empirical steps: analyzing highly-disaggregated agri-food export data of China to 213 countries or economies and attempting to find some stylized facts; consecutively decomposing China’s agri-food export volume into three trade margins and calculating each of them; based on an extended heterogeneity firm and trade model with the quality margin being introduced, investigating the source and pattern of China’s agri-food export growth and the role of relevant determinants.

Findings
The paper reveals that the relative quality upgrading explains most of the increase along the intensive margin, to which the relative price decrease has a negligible negative contribution. Simultaneously, the heterogeneity across products does matter, since we find that the relative quality improvement and relative product price decline are more prominent for the differentiated products with larger quantity expansion along the intensive margins.

Originality/value
With quality upgrading dynamically, we attribute China’s long-term agri-food export growth to the quantity penetration along the intensive margin. With the relative product price distinction reflecting factor costs and productivity differences across industries, the comparative quality upgrading in differentiated products might correlate with their upward production productivity.
Optimal exit dates for members of the GSF
Authors: Lally Martin 
Published: April 2016

Purpose
This paper aims to determine the optimal date for an employee to initiate the pension payments from the New Zealand Government Superannuation Fund (GSF), through retirement or job shifting.

Design/methodology/approach
The paper uses discounted cash flow methods in conjunction with mortality tables, inflation estimates and a range of values for the yield on inflation-adjusted bonds in New Zealand.

Findings
The paper finds that, if job shifting is costless, then the optimal exit date is between 60 and 65. If job switching is costly, then this paper determines the effective salary reduction arising from continuing to work at the GSF-associated job beyond the optimal job switching age under costless job switching, arising from the adverse impact on the present value of the pension benefits, so as to assist in deciding when to switch jobs or retire. These effective salary reductions are small below 65 but rapidly rise after that, thereby significantly discouraging work much beyond age 65.

Originality/value
This paper assists GSF members to determine when to switch jobs or retire.
Mortality after open aortic aneurysm surgery by Australasian surgeons trained in the endovascular era
Authors: Beiles C. Barry , Walker Stuart 
Published: April 2016

BackgroundReduced exposure of trainees to open repair (OR) of abdominal aortic aneurysm (AAA) during training has been considered detrimental to outcome. The Australasian experience is examined.MethodsThe Australasian Vascular Audit (AVA) was interrogated for AAA procedures between 1 January 2010 and 31 December 2014. Surgeons completing training before 2006 (group 1) were compared with those attaining their qualification subsequently (group 2). The Australian Institute of Health and Welfare (AIHW) database was also interrogated to confirm the trends over time of open and endovascular repair (EVAR) since 2000. Actual exposure to OR and EVAR of AAA by trainees from 2010 to 2014 was also extracted.ResultsOne hundred and forty‐six surgeons in group 1 performed 3049 OR compared with 997 for the 66 surgeons in group 2. Overall mortality for group 1 was 9.8% and for group 2, 15% (P < 0.0001). However, proportionately more ruptured AAA were treated in group 2 (31.5%) compared to group 1 (21.6%) (P < 0.0001). There was a slightly higher mortality in group 2 for ruptured but not intact aneurysm repair. Logistic regression analysis did not show the consultant group to be a significant variable in the model. EVAR was performed in 7409 patients during the study period; group 1 had a 1.5% mortality rate compared with 1.6% for group 2 (P = 0.76). AIHW data showed a trend of increasing EVAR with time. Considerable variation in OR exposure by trainees exists.ConclusionReduced exposure to OR by younger trainees did not significantly affect surgical outcome when compared with those surgeons trained in an earlier period.
Invasive plant management must be driven by a holistic understanding of invader impacts
Authors: Barney Jacob N. 
Published: April 2016

AbstractUnderstanding impacts of invasive plants is necessary to achieve conservation goals. In this issue of Applied Vegetation Science, Kelemen et al. identify that a widespread invader reduces native abundance, but not richness, by displacing weak competitors as invader cover increased. An enhanced understanding of the multitude of ecological impacts should be a primary element of invasive plant management.
The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis
Authors: Page Amy T. , Clifford Rhonda M. , Potter Kathleen , Schwartz Darren , Etherton‐Beer Christopher D. 
Published: April 2016

AimsDeprescribing is a suggested intervention to reverse the potential iatrogenic harms of inappropriate polypharmacy. The review aimed to determine whether or not deprescribing is a safe, effective and feasible intervention to modify mortality and health outcomes in older adults.MethodsSpecified databases were searched from inception to February 2015. Two researchers independently screened all retrieved articles for inclusion, assessed study quality and extracted data. Data were pooled using RevMan v5.3. Eligible studies included those where older adults had at least one medication deprescribed. The primary outcome was mortality. Secondary outcomes were adverse drug withdrawal events, psychological and physical health outcomes, quality of life, and medication usage (e.g. successful deprescribing, number of medications prescribed, potentially inappropriate medication use).ResultsA total of 132 papers met the inclusion criteria, which included 34 143 participants aged 73.8 ± 5.4 years. In nonrandomized studies, deprescribing polypharmacy was shown to significantly decrease mortality (OR 0.32, 95% CI: 0.17–0.60). However, this was not statistically significant in the randomized studies (OR 0.82, 95% CI 0.61–1.11). Subgroup analysis revealed patient‐specific interventions to deprescribe demonstrated a significant reduction in mortality (OR 0.62, 95% CI 0.43–0.88). However, generalized educational programmes did not change mortality (OR 1.21, 95% CI 0.86–1.69).ConclusionsAlthough nonrandomized data suggested that deprescribing reduces mortality, deprescribing was not shown to alter mortality in randomized studies. Mortality was significantly reduced when applying patient‐specific interventions to deprescribe in randomized studies.
Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review
Authors: Lee Shaun Wen Huey , Lai Nai Ming , Chaiyakunapruk Nathorn , Chong David Weng Kwai 
Published: April 2016

AimGlucose‐6‐phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals.MethodsWe searched 14 electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals. Additional publications were identified from manually searching textbooks, conference abstracts and the grey literature. All study designs were included as long as they contained clinical information. These gathered findings were summarized narratively.ResultsThirty‐two publications met inclusion criteria. These reported on 10 herbal and dietary supplements. Overall evidence linking haemolysis to a herbal/dietary supplement was only found for henna. No evidence of harm was observed for vitamin C, vitamin E, vitamin K, Gingko biloba and α‐lipoic acid.ConclusionsThe review showed that there was insufficient evidence to contravene the use of most herbal or dietary products at therapeutic doses in G6PD deficient subjects.
Early and extensive spinal white matter involvement in neuromyelitis optica
Authors: Hayashida Shotaro , Masaki Katsuhisa , Yonekawa Tomomi , Suzuki Satoshi O. , Hiwatashi Akio , Matsushita Takuya , Watanabe Mitsuru , Yamasaki Ryo , Suenaga Toshihiko , Iwaki Toru , Murai Hiroyuki , Kira Jun-ichi 
Published: April 2016

AbstractObjectivesStudies of longitudinally extensive spinal cord lesions (LESCLs) in neuromyelitis optica (NMO) have focused on gray matter, where the relevant antigen, aquaporin‐4 (AQP4), is abundant. Because spinal white matter pathology in NMO is not well characterized, we aimed to clarify spinal white matter pathology of LESCLs in NMO.MethodsWe analyzed 50 spinal cord lesions from eleven autopsied NMO/NMO spectrum disorder (NMOSD) cases. We also evaluated LESCLs with three or fewer spinal cord attacks by 3‐tesla MRI in 15 AQP4 antibody‐positive NMO/NMOSD patients and in 15 AQP4 antibody‐negative multiple sclerosis (MS) patients.ResultsPathological analysis revealed seven cases of AQP4 loss and four predominantly demyelinating cases. Forty‐four lesions from AQP4 loss cases involved significantly more frequently posterior columns (PC) and lateral columns (LC) than anterior columns (AC) (59.1%, 63.6%, and 34.1%, respectively). The posterior horn (PH), central portion (CP), and anterior horn (AH) were similarly affected (38.6%, 36.4% and 31.8%, respectively). Isolated perivascular inflammatory lesions with selective loss of astrocyte endfoot proteins, AQP4 and connexin 43, were present only in white matter and were more frequent in PC and LC than in AC (22.7%, 29.5% and 2.3%, Pcorr = 0.020, and Pcorr = 0.004, respectively). MRI indicated LESCLs more frequently affected PC and LC than AC in anti‐AQP4 antibody‐seropositive NMO/NMOSD (86.7%, 60.0% and 20.0%, Pcorr = 0.005, and Pcorr = 0.043, respectively) and AQP4 antibody‐seronegative MS patients (86.7%, 73.3% and 33.3%, Pcorr = 0.063, and Pcorr = 0.043, respectively). PH, CP and AH were involved in 93.3%, 86.7% and 73.3% of seropositive patients, respectively, and in 53.3%, 60.0% and 40.0% of seronegative patients, respectively.ConclusionsNMO frequently and extensively affects spinal white matter in addition to central gray matter, especially in PC and LC, where isolated perivascular lesions with astrocyte endfoot protein loss may emerge. Spinal white matter involvement may also appear in early NMO, similar to cerebral white matter lesions.