bluuebunny/crossref_metadata_2025_split huggingface dataset:
BUSINESS FEASIBILITY STUDY OF MACLOV MACARONI SHOP
Authors: Yuliana Debora , Sonny Sonny 
Published: September 2024

<p>In Indonesia, crackers are processed snacks. Not only ordinary crackers; many variants of crackers can be found in Indonesia, from the types of crackers to be flavor of certain types. This has provided a trend in recent years where this type of macaroni cracker has increased the growth of the cracker snack business in Indonesia. Then it was marked by the emergence of innovations in the taste of macaroni crackers which were very diverse so that they could lure consumers from the millennial generation to Z generation to be interested in buying them to be able to accompany them in all conditions. Maclov is targeted to provide profits that increase each quarter by 5-15% for the next 5 years. This business uses IDR 720,000,000 capital with an NPV of IDR 127,104,772 and will get BEP for 4 years and 3 months</p>
2D simulation of temperature distribution within large-scale PEM electrolysis stack based on thermal conductivity measurements
Authors: Eichner Benedikt J. , Amiri Mahshid N. , Burheim Odne S. , Lamb Jacob J. 
Published: September 2024

Polymer electrolyte membrane electrolyser cells (PEMEC) are recognized as highly suitable for large-scale green hydrogen production from variable renewable sources. To enhance production rates in PEMECs, current densities have gradually increased, resulting in elevated heat generation within the electrolysis cells. Consequently, the consideration of thermal gradients within individual cells within the stacks becomes increasingly crucial. This study presents a 2D thermal numerical steady-state model of an industrial-sized PEMEC stack, predicting thermal gradients within the cells in both stacking direction and along the channels of the flow fields. Through-plane thermal conductivities were measured ex-situ for the titanium felt porous transport layer (PTL), Tion5-W PFSA membrane, and PEMEC catalyst layers (CLs). At a compaction pressure of 16 bar, the wet PTL exhibited a thermal conductivity of 2.7 ± 0.2 W m−1 K−1, the wet membrane of 0.31 ± 0.01 W m−1 K−1, and the wet CLs of 0.19 ± 0.03 W m−1 K−1. When modelled, thermal gradients of 16.5 ± 0.6 K in parallel flow and 17.6 ± 0.5 K in counter-flow were predicted within cells with a 1 m2 cell area, operating at 2 A cm−2. The counter-flow arrangement demonstrated a 0.2% advantage in voltage efficiency. An increase in current density to 3 A cm−2 resulted in a 10 K rise in thermal differences in both parallel and counter-flow conditions. However, the use of a sintered PTL reduced thermal gradients by approximately 3.7 K at 2 A cm−2. The simulation indicated a 20%–40% increase in maximal thermal gradients within the stack compared to models using lumped properties within the cells, emphasizing the significance of considering in-cell thermal gradients at the stack level.
Global research trends on the links between gut microbiota and radiotherapy: a bibliometric analysis (2004-2023)
Authors: Wang Shuyuan , Yuan Zhen , Gao Xiaohui , Wu Jiaxing , Ren Yifan , Yu Xiufeng , Li Jianxiong , Wei Wei 
Published: September 2024

BackgroundThere is a crosstalk between gut microbiota and radiotherapy. The aim of this study is to use bibliometric analysis to explore the research status and development trends of research on gut microbiota and radiotherapy.MethodsA literature search regarding publications on gut microbiota and radiotherapy from 2004 to 2023 was retrieved. CiteSpace and VOSviewer were used to conduct the bibliometric analysis. The growth rate of publications, leading countries and institutions, preferred journals, top authors and co-cited authors, top co-cited references, keywords and citation were analyzed in this study.ResultsA total of 2821 papers were extracted. The number of papers has increased rapidly over the past decade, especially after 2017. The USA and China had the most publications and made great contributions to this field. The Chinese Academy of Sciences stood out as the institution with the highest number of publications, followed by the Chinese Academy of Medical Sciences &amp; Peking Union Medical College. The most influential authors were Fan Saijun and Li Yuan. PLoS One had the most publications and the most total citations. Highly cited papers and high-frequency keywords illustrated the current status and trends. Furthermore, analysis of keyword with burst revealed that immunotherapy, acid, intestinal barrier, therapy, immunotherapy, fecal microbiota transplantation, etc, are at the forefront of research in this area.ConclusionThis study provides an overview of research on gut microbiota and radiotherapy, highlighting influential contributors, impactful publications, and emerging trends. Our finding suggests avenues for further exploration to improve clinical outcomes.
Prediction of the potential distribution area of Jacaranda mimosifolia in China under climate change using the MaxEnt model
Authors: Li Xiaomei , Zhang Guowu , Xie Chunping , Qiu Jianhuang , Liu Xuefeng 
Published: September 2024

IntroductionJacaranda mimosifolia, native to South America, is a notable ornamental tree widely used in Chinese urban landscaping due to its aesthetic and environmental value. Despite its popularity, the cultivation of J. mimosifolia in China faces challenges, including intermittent failures in various regions. This study assesses the potential distribution of J. mimosifolia in China and its response to climate change, providing insights for its application and promotion.MethodsUsing MaxEnt software, we developed an ecological niche model from 218 distribution records and selected 10 environmental variables to predict the tree’s distribution under various climate scenarios (SSP126, SSP245, SSP370).ResultsOur model demonstrates high predictive accuracy (AUC &gt; 0.90) across scenarios, identifying key factors such as the mean temperature of the coldest quarter (bio11), precipitation of the driest month (bio14), temperature annual range (bio7), and minimum temperature of the coldest month (bio6). Their relative contribution rates were 49.3%, 18.4%, 15.6%, and 2.0%, respectively. The average temperature of the coldest quarter was not lower than 5°C, with the ideal range being 7.38~14.88°C. Currently, J. mimosifolia predominantly thrives in Taiwan, Fujian, Guangdong, Hainan, Guangxi, Yunnan, and to a lesser extent in the Sichuan Basin, southern Guizhou, Tibet, Hunan, Jiangxi, and Zhejiang province, covering a total area of approximately 122.19 × 104 km2. Future predictions indicate that under the SSP126 scenario, the most significant contraction occurs between the 2050s and 2070s, with a total change of −1.08 × 104 km2. Conversely, under the SSP370 scenario, the greatest expansion is observed from the 2030s to the 2050s, amounting to a change of 2.08 × 104 km2. Suitable area expansion is anticipated in most periods and scenarios, except for SSP126 in the 2070s, SSP245 in the 2050s, and SSP370 in the 2030s and 2070s. The distribution center shifts observed include movements northwestward, southwestward, and eastward with distances ranging from 5.12 km to 18.84 km. These shifts are likely driven by global warming, resulting in movements to higher elevations and latitudes.DiscussionThese predictions will provide a solid theoretical foundation for the future application of J. mimosifolia in urban landscaping and serve as a valuable reference for its introduction and cultivation.
Exploring the causal link among statin drugs and the osteoarthritis risk based on Mendelian randomization research
Authors: Chen Wenjie , Sun Zhi , Xiong Xinhai , Tan Haitao , Hu Junhao , Liu Chenrui , Chen Cheng 
Published: September 2024

PurposeStatins may have a protective effect against osteoarthritis (including knee osteoarthritis and hip osteoarthritis); however, the link between statins and osteoarthritis risk is incompletely established. The aim of this study was to explore the relationship between statins and osteoarthritis risk through Mendelian randomization analysis using pooled information from a large population-wide genome-wide association study (GWAS).MethodsStatin-related single-nucleotide polymorphisms (SNPs) were obtained from FinnGen’s latest 9th edition database, and data on osteoarthritis, knee osteoarthritis, and hip osteoarthritis were acquired from the IEU OpenGWAS, the UK Biobank, and Arthritis Research UK Osteoarthritis Genetics (ArcOGEN) database, respectively. The inverse-variance weighting method is an important analysis method to estimate the causal effect. Weighted median method, simple median method, weighted median estimator method, and MR–Egger regression were employed to supplement the explanation. Odds ratio and 95%CI were used to evaluate the causal relationship among statins and the osteoarthritis risk, osteoarthritis in the knee, and osteoarthritis in the hip. Second, sensitivity analysis was carried out to validate the reliability of the results. Cochran’s Q test was employed to test heterogeneity, MR–Egger intercept was employed to test whether horizontal pleiotropy existed, and single-nucleotide polymorphisms with potential influence were determined by the one-method analysis.Results(1) The results of the inverse variance weighting method showed Gene prediction indicated that statins were associated with osteoarthritis (OR = 0.998, 95% CI: 0.996–0.999, P = 0.01) and knee osteoarthritis (OR = 0.964, 95% CI: knee (0.940–0.989, P = 0.005) and hip osteoarthritis risk were associated (OR = 0.928, 95% CI: 0.901–0.955, P = 4.28 × 10−7). (2) MR–Egger intercept analysis did not detect potential horizontal pleiotropy (osteoarthritis: P = 0.658; knee osteoarthritis: P = 0.600; and hip osteoarthritis: P = 0.141). (3) The findings provide evidence that statins reduce osteoarthritis risk, osteoarthritis in the knee, and osteoarthritis in the hip, as described in observational studies, and the specific mechanisms by which statins treat osteoarthritis require further investigation.ConclusionThe results of this study, at the genetic level, reveal a negative causal relationship between statins and osteoarthritis, and this causal relationship is also present in knee and hip osteoarthritis. This study provides evidence against the potential of statins in the treatment of osteoarthritis, prompting the clinical treatment of osteoarthritis to consider improving the start and compliance of statins in the future.
Integrated transcriptomic analysis and machine learning for characterizing diagnostic biomarkers and immune cell infiltration in fetal growth restriction
Authors: Wei Xing , Liu Zesi , Cai Luyao , Shi Dayuan , Sun Qianqian , Zhang Luye , Zhou Fenhe , Sun Luming 
Published: September 2024

BackgroundFetal growth restriction (FGR) occurs in 10% of pregnancies worldwide. Placenta dysfunction, as one of the most common causes of FGR, is associated with various poor perinatal outcomes. The main objectives of this study were to screen potential diagnostic biomarkers for FGR and to evaluate the function of immune cell infiltration in the process of FGR.MethodsFirstly, differential expression genes (DEGs) were identified in two Gene Expression Omnibus (GEO) datasets, and gene set enrichment analysis was performed. Diagnosis-related key genes were identified by using three machine learning algorithms (least absolute shrinkage and selection operator, random forest, and support vector machine model), and the nomogram was then developed. The receiver operating characteristic curve, calibration curve, and decision curve analysis curve were used to verify the validity of the diagnostic model. Using cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT), the characteristics of immune cell infiltration in placental tissue of FGR were evaluated and the candidate key immune cells of FGR were screened. In addition, this study also validated the diagnostic efficacy of TREM1 in the real world and explored associations between TREM1 and various clinical features.ResultsBy overlapping the genes selected by three machine learning algorithms, four key genes were identified from 290 DEGs, and the diagnostic model based on the key genes showed good predictive performance (AUC = 0.971). The analysis of immune cell infiltration indicated that a variety of immune cells may be involved in the development of FGR, and nine candidate key immune cells of FGR were screened. Results from real-world data further validated TREM1 as an effective diagnostic biomarker (AUC = 0.894) and TREM1 expression was associated with increased uterine artery PI (UtA-PI) (p-value = 0.029).ConclusionFour candidate hub genes (SCD, SPINK1, TREM1, and HIST1H2BB) were identified, and the nomogram was constructed for FGR diagnosis. TREM1 was not only associated with a variety of key immune cells but also correlated with increased UtA-PI. The results of this study could provide some new clues for future research on the prediction and treatment of FGR.
Thalamic-limbic circuit dysfunction and white matter topological alteration in Parkinson’s disease are correlated with gait disturbance
Authors: Ren Qingguo , Zhao Shuai , Yu Rong , Xu Ziliang , Liu Shuangwu , Zhang Bin , Sun Qicai , Jiang Qingjun , Zhao Cuiping , Meng Xiangshui 
Published: September 2024

BackgroundLimbic structures have recently garnered increased attention in Parkinson’s disease (PD) research. This study aims to explore changes at the whole-brain level in the structural network, specifically the white matter fibres connecting the thalamus and limbic system, and their correlation with the clinical characteristics of patients with PD.MethodsBetween December 2020 and November 2021, we prospectively enrolled 42 patients with PD and healthy controls at the movement disorder centre. All participants underwent diffusion tensor imaging (DTI), 3D T1-weighted imaging (3D-T1WI), and routine brain magnetic resonance imaging on a 3.0 T MR scanner. We employed the tract-based spatial statistical (TBSS) analytic approach, examined structural network properties, and conducted probabilistic fibre tractography to identify alterations in white matter pathways and the topological organisation associated with PD.ResultsIn patients with PD, significant changes were observed in the fibrous tracts of the prefrontal lobe, corpus callosum, and thalamus. Notably, the fibrous tracts in the prefrontal lobe and corpus callosum showed a moderate negative correlation with the Freezing of Gait Questionnaire (FOG-Q) scores (r = −0.423, p = 0.011). The hippocampus and orbitofrontal gyrus exhibited more fibre bundle parameter changes than other limbic structures. The mean streamline length between the thalamus and the orbitofrontal gyrus demonstrated a moderate negative correlation with Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III (r = −0.435, p = 0.006). Topological parameters, including characteristic path length (Lp), global efficiency (Eg), normalised shortest path length (λ) and nodal local efficiency (Nle), correlated moderately with the MDS-UPDRS, HAMA, MoCA, PDQ-39, and FOG-Q, respectively.ConclusionDTI is a valuable tool for detecting changes in water molecule dispersion and the topological structure of the brain in patients with PD. The thalamus may play a significant role in the gait abnormalities observed in PD.
Case report: Levodopa challenge test is important in identifying dopamine-induced freezing of gait in patient with Parkinson’s disease
Authors: Xu Shan-Shan , Zhu Shi-Guo , Yuan Cheng-Xiang , Zeng Guo-Ling , Li Xiao-Tian , Liu Rong-Pei , Huang Shi-Shi , Zhang Xiong , Wang Jian-Yong 
Published: September 2024

IntroductionFreezing of gait (FOG) is a disabling and heterogeneous symptom in patients with Parkinson’s disease (PD). Among them, dopamine-induced FOG is rare and difficult to identify. The treatment of dopamine-induced FOG is complex.Case presentationWe herein presented a case of PD patient who complicated with refractory FOG. It was identified as dopamine-induced FOG during levodopa challenge test. Her symptoms were alleviated after we reduced the total equivalent dosage of levodopa.ConclusionOur report emphasizes the importance of levodopa challenge test in identifying different types of FOG, which is very important for further adjusting treatment.
An updated systematic review and meta-analysis of the efficacy and safety of early oral feeding vs. traditional oral feeding after gastric cancer surgery
Authors: Xu Dong , Li Junping , Liu Jinchao , Wang Pingjiang , Dou Jianjian 
Published: September 2024

IntroductionEarly oral feeding (EOF) has been shown to improve postoperative recovery for many surgeries. However, surgeons are still skeptical about EOF after gastric cancer surgery due to possible side effects. This updated systematic review and meta-analysis aimed to investigate the efficacy and safety of EOF in patients after gastric cancer surgery.MethodsRandomized controlled trials (RCTs) investigating EOF in patients after gastric cancer surgery were searched in the databases of PubMed, Embase, Clinicaltrials.gov, and Cochrane from 2005 to 2023, and an updated meta-analysis was performed using RevMan 5.4 software.ResultsThe results of 11 RCTs involving 1,352 patients were included and scrutinized in this analysis. Hospital days [weighted mean difference (WMD), −1.72; 95% confidence interval (CI), −2.14 to −1.30; p&lt;0.00001), the time to first flatus (WMD, −0.72; 95% CI, −0.99 to −0.46; p&lt;0.00001), and hospital costs (WMD, −3.78; 95% CI, −4.50 to −3.05; p&lt;0.00001) were significantly decreased in the EOF group. Oral feeding tolerance [risk ratio (RR), 1.00; 95% CI, 0.95–1.04; p=0.85), readmission rates (RR, 1.28; 95% CI, 0.50–3.28; p=0.61), postoperative complications (RR, 1.02; 95% CI, 0.81–1.29; p=0.84), anastomotic leakage (RR, 0.83; 95% CI, 0.25–2.78; p=0.76), and pulmonary infection (RR, 0.65; 95% CI, 0.31–1.39; p=0.27) were not significantly statistical between two groups.ConclusionThis meta-analysis reveals that EOF could reduce hospital days, the time to first flatus, and hospital costs, but it was not associated with oral feeding tolerance, readmission rates, or postoperative complications especially anastomotic leakage and pulmonary infection, regardless of whether laparoscopic or open surgery, partial or total gastrectomy, or the timing of EOF initiation.
Dupilumab treatment reduces caregiver-reported skin pain in patients with moderate-to-severe atopic dermatitis aged 6 months to 5 years
Authors: Paller Amy S. , Silverberg Jonathan I. , Gonzalez Mercedes E. , Schneider Lynda C. , Sidbury Robert , Chen Zhen , Bansal Ashish , Wang Zhixiao , Prescilla Randy 
Published: September 2024

BackgroundModerate-to-severe atopic dermatitis (AD) often has a profound impact on the quality of life of young children and their caregivers. One of the most burdensome symptoms reported by patients is skin pain.MethodsThis post hoc analysis focuses on the impact of dupilumab treatment on skin pain in young children using data from the LIBERTY AD PRESCHOOL part B (NCT03346434), a 16-week randomized, double-blind, placebo-controlled, phase 3 study in 162 children aged 6 months to 5 years with moderate-to-severe AD receiving dupilumab or placebo, plus topical corticosteroids (TCS). Analyses were performed on the full analysis set and subgroups of patients who did not achieve an Investigator's Global Assessment score of 0 or 1 (IGA &gt;1 subgroup), or who did not achieve a 75% improvement from baseline in the Eczema Area and Severity Index (&lt;EASI-75 subgroup), at week 16 (patients who did not achieve the primary or key secondary endpoints in LIBERTY AD PRESCHOOL part B).ResultsAt week 16, change from baseline in the skin pain NRS was significantly greater in the dupilumab group vs. the placebo group (−3.93 vs. −0.62, p &lt; 0.0001) and significantly more patients receiving dupilumab vs. placebo achieved a clinically meaningful improvement at week 16 (47.2% vs. 10.8%, p &lt; .0001). Similar results between dupilumab vs. placebo were seen in the two subgroups IGA &gt;1 and &lt;EASI-75.ConclusionsThis analysis showed rapid, clinically meaningful, and statistically significant improvements in skin pain in patients treated with dupilumab plus TCS vs. placebo plus TCS.
Current status and influencing factors of prophylactic use of proton pump inhibitors in internal medicine inpatients receiving glucocorticoid therapy
Authors: Liu Pengpeng , Li Guangyao , Wu Qian , Han Mei 
Published: September 2024

BackgroundThe actual situation and influencing factors of prophylactic use of proton pump inhibitors (PPIs) in internal medicine inpatients receiving glucocorticoid therapy are rarely reported. This study aimed to investigate the current status and influencing factors of prophylactic use of PPIs in internal medicine inpatients receiving glucocorticoid therapy to provide a basis for rational prophylactic use of PPIs.MethodsInternal medicine inpatients receiving glucocorticoid therapy from February 2023 to September 2023 were included. Information on the prophylactic use of PPIs was collected and analyzed by clinical pharmacists. Associated factors with prophylactic use of PPIs were analyzed by univariable and multivariable logistic regression.Results980 inpatients were finally included in our study, of which 271 (27.7%) inpatients received prophylactic use of PPIs. Among the inpatients prescribed PPIs, 90 inpatients received a standard dose of PPIs twice a day. Multiple logistic regression analysis showed that age ≥80 years [OR = 7.009, 95% CI (1.424, 34.495), p = 0.017], history of gastroesophageal reflux disease (GERD) [OR = 2.047, 95% CI (1.338, 3.133), p = 0.001], low platelet count [OR = 0.997, 95% CI (0.994, 0.999), p = 0.004], number of concomitant diseases [OR = 1.104, 95% CI (1.056, 1.153), p &lt; 0.001], junior doctors [OR = 1.755, 95% CI (1.248, 2.468), p = 0.001], glucocorticoid dose (higher than 50 mg, measured by methylprednisolone) [OR = 2.455, 95% CI (1.371, 4.395), p = 0.003], antiplatelet agents [OR = 2.567, 95% CI (1.456, 4.524), p = 0.001], immunosuppressants [OR = 1.477, 95% CI (1.014, 2.153), p = 0.042], and betahistine [OR = 5.503, 95% CI (1.124, 26.950), p = 0.035] were associated with more prophylactic use of PPIs.ConclusionThe prophylactic use of PPIs in internal medicine inpatients receiving glucocorticoid therapy is common in China. Clinical pharmacists will take targeted measures to promote the rational use of PPIs according to the results of this study.