bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction between a Vertical Turbulent Jet and a Thermocline
Authors: Ezhova Ekaterina , Cenedese Claudia , Brandt Luca 
Published: September 2016

AbstractThe behavior of an axisymmetric vertical turbulent jet in an unconfined stratified environment is studied by means of well-resolved, large-eddy simulations. The stratification is two uniform layers separated by a thermocline. This study considers two cases: when the thermocline thickness is small and on the order of the jet diameter at the thermocline entrance. The Froude number of the jet at the thermocline varies from 0.6 to 1.9, corresponding to the class of weak fountains. The mean jet penetration, stratified turbulent entrainment, jet oscillations, and the generation of internal waves are examined. The mean jet penetration is predicted well by a simple model based on the conservation of the source energy in the thermocline. The entrainment coefficient for the thin thermocline is consistent with the theoretical model for a two-layer stratification with a sharp interface, while for the thick thermocline entrainment is larger at low Froude numbers. The data reveal the presence of a secondary horizontal flow in the upper part of the thick thermocline, resulting in the entrainment of fluid from the thermocline rather than from the upper stratification layer. The spectra of the jet oscillations in the thermocline display two peaks, at the same frequencies for both stratifications at fixed Froude number. For the thick thermocline, internal waves are generated only at the lower frequency, since the higher peak exceeds the maximal buoyancy frequency. For the thin thermocline, conversely, the spectra of the internal waves show the two peaks at low Froude numbers, whereas only one peak at the lower frequency is observed at higher Froude numbers.
Monthly and Seasonal Rainfall Forecasting in Southern Brazil Using Multiple Discriminant Analysis
Authors: Viana Denilson Ribeiro , Sansigolo Clóvis Angeli 
Published: September 2016

Abstract
A multiple discriminant analysis was employed to forecast monthly and seasonal rainfall in southern Brazil. The methodology used includes six steps: data acquisition, preprocessing, feature extraction, feature selection, classification, and evaluation. The predictors (atmospheric, surface, and oceanic variables) and predictand (rainfall) were obtained from the Twentieth Century Reanalysis (version 2), as well as from the HadISST1 (Met Office Hadley Centre) and Global Precipitation Climatology Centre (GPCC) databases. The definition of key regions (feature extraction step) was performed using spatial principal component analysis. In the selection step, the rainfall time series were allocated into terciles, which were related to the predictors via multiple discriminating analyses. The results revealed that ⅓ of the predictors are associated with atmospheric pressure and also emphasized the role of atmospheric circulation over the Antarctic region and its surroundings. Surface variables (albedo and soil moisture) were also of great importance in the forecasting. The average skill score (gain over climatology) was 29%. It is concluded that the proposed model is a reliable alternative for use in forecasting monthly and seasonal rainfall over southern Brazil.
Validation of the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis
Authors: San Giorgi Michel R. M. , Aaltonen Leena‐Maija , Rihkanen Heikki , Tjon Pian Gi Robin E. A. , van der Laan Bernard F. A. M. , Hoekstra‐Weebers Josette E. H. M. , Dikkers Frederik G. 
Published: September 2016

ObjectiveThere is no specific clinical tool for physicians to detect psychosocial and physical distress or health care need in patients with recurrent respiratory papillomatosis (RRP). The main aim of this study is to validate the RRP‐adapted Distress Thermometer and Problem List (DT&PL).Study DesignProspective cross‐sectional questionnaire research.SettingAcademic tertiary care medical centers in Groningen, Netherlands, and Helsinki, Finland.Subjects and MethodsNinety‐one juvenile‐ and adult‐onset RRP patients participated from the departments of otorhinolaryngology–head and neck surgery of the University Medical Center Groningen, Netherlands, and Helsinki University Hospital, Finland. The Hospital Anxiety and Depression Scale was used as the gold standard.ResultsA DT cutoff score ≥4 gave the best sensitivity and specificity. Thirty‐one percent of patients had significant distress according to the DT cutoff. Significantly more patients with a score above than under the cutoff had a referral wish. The PL appeared to be reliable. Patients’ opinions on the DT&PL were largely favorable.ConclusionThe Dutch and Finnish versions of the DT&PL are valid, reliable screening tools for distress in RRP patients.
Novel Dissection Station for Endolaryngeal Microsurgery and Laser Surgery: Development and Dissection Course Experience
Authors: Mattioli Francesco , Presutti Livio , Caversaccio Marco , Bonali Marco , Anschuetz Lukas 
Published: September 2016

ObjectiveWe aimed to develop and validate an ex vivo dissection station for endolaryngeal surgery suitable for different kinds of laryngeal specimen and any type of operating technique (CO2 laser, cold instruments by endoscopic or microscopic techniques).Study DesignExperimental construction and validation of a highly specialized dissection station.SettingLaboratory and international dissection course.MethodsWe designed a lightweight dissection station made of polycarbonate resin approved for use with a CO2 laser. The cylindrical box hosts an articulated laryngeal support. The laryngoscope is positioned on an articulated arm, which is fixed on the construction’s footplate. Validation of the larynx box was performed during an international dissection course on laryngeal surgery held in January 2016.ResultsWe assessed the suitability of our novel dissection station among specialized laryngologists with a mean experience of 14 years. Feedback from the participants was very positive, with a mean general impression of 9.5 (out of 10 points) and a recommendation score of 9.6 for further use. Its utility in transforming the taught surgical steps into daily practice has been highly recognized, with a score of 9.5.ConclusionThe lightweight and transparent larynx box is suitable for any kind of laryngeal specimen, and any surgical intervention can be taught at reasonable cost. It is safe and suitable for use with CO2 lasers. Validation among experienced surgeons revealed its suitability in the teaching of endolaryngeal microsurgery and laser surgery.
Can the multiphasic computed tomography be useful in the clinical management of small renal masses?
Authors: Gaudiano Caterina , Schiavina Riccardo , Vagnoni Valerio , Busato Fiorenza , Borghesi Marco , Bandini Marco , Di Carlo Maddalena , Brunocilla Eugenio , Martorana Giuseppe , Golfieri Rita 
Published: September 2016

Background Small renal masses (SRMs; ≤4 cm) represent a challenging issue. Computed tomography (CT) is widely used for investigating renal tumors even if its ability to differentiate among the different subtypes has not yet been definitively established. Purpose To assess the potential role of the morphological features and angiodynamic behavior on multiphasic CT in the preoperative evaluation of SRMs. Material and Methods The CT images of 80 patients with SRMs who underwent surgical resection at our institution were retrospectively reviewed. The morphological features, the pattern, and the quantitative analysis of enhancement were assessed for each lesion and were correlated with the histological subtypes. Results Overall, 81 SRMs were evaluated. Final pathological examination showed 30 (37%) oncocytomas, 22 (27.2%) clear cell renal cell carcinomas (ccRCCs), 16 (19.8%) papillary RCCs (pRCCs), and 13 (16%) chromophobe RCCs (chRCCs). Of the morphological features, only necrosis was significantly associated with ccRCC ( P = 0.047). The analysis of enhancement allowed the identification of two groups of lesions, based on arterial behavior: hypervascular (oncocytomas/ccRCC) and hypovascular (chRCC/pRCC) lesions. A significant difference between the two groups in terms of degree of enhancement on CT phases was found ( P < 0.05); this was also confirmed by the receiver operating characteristic (ROC) analysis. Conclusion Except for necrosis, the morphological features are not useful in making a correct diagnosis in the case of SRMs. The angiodynamic behavior on multiphasic CT showed high accuracy in differentiating between hypovascular and hypervascular tumors; this differentiation could be useful for deciding on the most appropriate clinical management of SRMs.
PROPER: Development of an Early Pediatric Intensive Care Unit Readmission Risk Prediction Tool
Authors: Kaur Harsheen , Naessens James M. , Hanson Andrew C. , Fryer Karen , Nemergut Michael E. , Tripathi Sandeep 
Published: September 2016

Objective: No risk prediction model is currently available to measure patient’s probability for readmission to the pediatric intensive care unit (PICU). This retrospective case–control study was designed to assess the applicability of an adult risk prediction score (Stability and Workload Index for Transfer [SWIFT]) and to create a pediatric version (PRediction Of PICU Early Readmissions [PROPER]). Design: Eighty-six unplanned early (<48 hours) PICU readmissions from January 07, 2007, to June 30, 2014, were compared with 170 random controls. Patient- and disease-specific data and PICU workload factors were compared across the 2 groups. Factors statistically significant on multivariate analysis were included in the creation of the risk prediction model. The SWIFT scores were calculated for cases and controls and compared for validation. Results: Readmitted patients were younger, weighed less, and were more likely to be admitted from the emergency department. There were no differences in gender, race, or admission Pediatric Index of Mortality scores. A higher proportion of patients in the readmission group had a Pediatric Cerebral Performance Category in the moderate to severe disability category. Cases and controls did not differ with respect to staff workload at discharge or discharge day of the week; there was a much higher proportion of patients on supplemental oxygen in the readmission group. Only 2 of 5 categories in the SWIFT model were significantly different, and although the median SWIFT score was significantly higher in the readmissions group, the model discriminated poorly between cases and controls (area under the curve: 0.613). A 7-category PROPER score was created based on a multiple logistic regression model. Sensitivity of this model (score ≥12) for the detection of readmission was 81% with a positive predictive value of 0.50. Conclusion: We have created a preliminary model for predicting patients at risk of early readmissions to the PICU from the hospital floor. The SWIFT score is not applicable for predicting the risk for pediatric population.
The influence of coping styles on long-term employment in multiple sclerosis: A prospective study
Authors: Grytten Nina , Skår Anne BR , Aarseth Jan Harald , Assmus Jorg , Farbu Elisabeth , Lode Kirsten , Nyland Harald I , Smedal Tori , Myhr Kjell Morten 
Published: September 2016

Background: The aim was to investigate predictive values of coping styles, clinical and demographic factors on time to unemployment in patients diagnosed with multiple sclerosis (MS) during 1998–2002 in Norway. Method: All patients ( N = 108) diagnosed with MS 1998–2002 in Hordaland and Rogaland counties, Western Norway, were invited to participate in the long-term follow-up study in 2002. Baseline recordings included disability scoring (Expanded Disability Status Scale (EDSS)), fatigue (Fatigue Severity Scale (FSS)), depression (Beck Depression Inventory (BDI)), and questionnaire assessing coping (the Dispositional Coping Styles Scale (COPE)). Logistic regression analysis was used to identify factors associated with unemployed at baseline, and Cox regression analysis to identify factors at baseline associated with time to unemployment during follow-up. Results: In all, 41 (44%) were employed at baseline. After 13 years follow-up in 2015, mean disease duration of 22 years, 16 (17%) were still employed. Median time from baseline to unemployment was 6 years (±5). Older age at diagnosis, female gender, and depression were associated with patients being unemployed at baseline. Female gender, long disease duration, and denial as avoidant coping strategy at baseline predicted shorter time to unemployment. Conclusion: Avoidant coping style, female gender, and longer disease duration were associated with shorter time to unemployment. These factors should be considered when advising patients on MS and future employment.
Examining the effect of reduced input on language development: The case of gender acquisition in Russian as a non-dominant and dispreferred language by a bilingual Turkish–Russian child
Authors: Antonova Ünlü Elena , Wei Li 
Published: September 2016

Aims and objectives/purpose/research questions: The main research question we seek to answer in the present study is: “What effect does reduced input in the non-dominant and dispreferred language have on the acquisition of Russian gender morphology by a bilingual Turkish–Russian child: Is it still sufficient for its monolingual-like development or can it cause incomplete acquisition of Russian gender morphology, at least, in some domains?” Design/methodology/approach: This study is a longitudinal case study. Data and analysis: The main source of data collection is video and audio recordings. Twenty-five recordings are available. They cover the period of between two years and 11 months (2;11) and 4;0. The data are examined in terms of the availability of masculine, feminine and neuter form-related genders, as well as availability of feminine and masculine semantic-related genders of nouns and pronouns in the first-, second- and third-person contexts. We look into whether the data of the bilingual child is marked with deviations from monolingual Russian data and/or incomplete acquisition of gender in any domain. Findings/conclusions: The findings of the present study, on the one hand, support the view that, by and large, reduced to a certain degree, input is still sufficient for monolingual-like language development; on the other hand, it demonstrates that reduced input may lead to non-monolingual-like and/or incomplete acquisition and, therefore, appears to be a main factor determining the development of a language and accounting for its strengths and weaknesses.
Outcomes of CLL patients treated with sequential kinase inhibitor therapy: a real world experience
Authors: Mato Anthony R. , Nabhan Chadi , Barr Paul M. , Ujjani Chaitra S. , Hill Brian T. , Lamanna Nicole , Skarbnik Alan P. , Howlett Christina , Pu Jeffrey J. , Sehgal Alison R. , Strelec Lauren E. , Vandegrift Alexandra , Fitzpatrick Danielle M. , Zent Clive S. , Feldman Tatyana , Goy Andre , Claxton David F. , Bachow Spencer Henick , Kaur Gurbakhash , Svoboda Jakub , Nasta Sunita Dwivedy , Porter David , Landsburg Daniel J. , Schuster Stephen J. , Cheson Bruce D. , Kiselev Pavel , Evens Andrew M. 
Published: September 2016

Key Points
Toxicity was the most common reason for discontinuation of ibrutinib or idelalisib in treated patients with CLL. KI-intolerant patients, but less so those with CLL progression, can be successfully treated with an alternate KI.
Jackson Pollock’s Number 1A, 1948: a non-invasive study using macro-x-ray fluorescence mapping (MA-XRF) and multivariate curve resolution-alternating least squares (MCR-ALS) analysis
Authors: Martins A. , Coddington J. , Van der Snickt G. , van Driel B. , McGlinchey C. , Dahlberg D. , Janssens K. , Dik J. 
Published: September 2016

Abstract
Jackson Pollock’s Number 1A, 1948 painting was investigated using in situ scanning macro-x-ray fluorescence mapping (MA-XRF) to help characterize the artist’s materials and his creative process. A multivariate curve resolution-alternating least squares (MCR-ALS) approach was used to examine the hyperspectral data and obtain distribution maps and signature spectra for the paints he used. The composition of the paints was elucidated based on the chemical elements identified in the signature spectra and a tentative list of pigments, fillers and other additives is proposed for eleven different paints and for the canvas. The paint distribution maps were used to virtually reconstruct the artist process and document the sequence and manner in which Pollock applied the different paints, using deliberate and specific gestures.
Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling
Authors: Wright Helen L , Makki Fatima A , Moots Robert J , Edwards Steven W 
Published: September 2016

Abstract
Our aim was to determine whether rheumatoid arthritis (RA) low-density granulocytes (LDGs) are functionally different from RA neutrophils. LDGs from 32 RA patients were characterized using flow cytometry and quantitative PCR (qPCR). RNA sequencing (RNA-Seq) was carried out on paired RA LDGs and neutrophils (n = 4) and validated using qPCR. Functional assays included chemotaxis, phagocytosis, reactive oxygen species (ROS) production, cell-cycle analysis, apoptosis, neutrophil extracellular trap (NET)osis, and measurement of cytokine production (n ≥ 5 paired RA LDGs/neutrophils). RA LDGs had a substantially altered transcriptome, expressing &gt;5000 genes at significantly different levels compared with RA neutrophils, including elevated levels of transcripts for granule proteins [including elastase and myeloperoxidase (MPO)] and cell-cycle genes [including cyclin-dependent kinase (CDK)2, CDK4, and CDK6]. Approximately 1% of RA LDGs stained positive for the G2/S phase of the cell cycle. RA LDGs had a significantly lower constitutive rate of apoptosis compared with RA neutrophils and did not respond to TNF-α in culture. Expression of transcripts for cytokines and cytokine receptors was lower in RA LDGs. NET formation was lower in LDGs in response to PMA compared with RA neutrophils. Chemotaxis and phagocytosis was lower in RA LDGs compared with neutrophils. RA LDGs produced significantly lower amounts of ROS in response to fMLP following priming with TNF-α. Expression of TNFR1 and -2 mRNA and protein was significantly lower in LDGs. We conclude that RA LDGS are functionally different from RA neutrophils, representing an immature neutrophil population within peripheral blood. Their enhanced survival properties and decreased TNF signaling are likely to have important consequences for disease pathology and response to therapy.
Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer
Authors: Meyer Larissa A. , Cronin Angel M. , Sun Charlotte C. , Bixel Kristin , Bookman Michael A. , Cristea Mihaela C. , Griggs Jennifer J. , Levenback Charles F. , Burger Robert A. , Mantia-Smaldone Gina , Matulonis Ursula A. , Niland Joyce C. , O’Malley David M. , Wright Alexi A. 
Published: September 2016

Purpose In 2010, a randomized clinical trial demonstrated noninferior survival for patients with advanced ovarian cancer who were treated with neoadjuvant chemotherapy (NACT) compared with primary cytoreductive surgery (PCS). We examined the use and effectiveness of NACT in clinical practice. Patients and Methods A multi-institutional observational study of 1,538 women with stages IIIC to IV ovarian cancer who were treated at six National Cancer Institute–designated cancer centers. We examined NACT use in patients who were diagnosed between 2003 and 2012 (N = 1,538) and compared overall survival (OS), morbidity, and postoperative residual disease in a propensity-score matched sample of patients (N = 594). Results NACT use increased from 16% during 2003 to 2010 to 34% during 2011 to 2012 in stage IIIC disease ( Ptrend < .001), and from 41% to 62% in stage IV disease ( Ptrend < .001). Adoption of NACT varied by institution, from 8% to 30% for stage IIIC disease (P < .001) and from 27% to 61% ( P = .007) for stage IV disease during this time period. In the matched sample, NACT was associated with shorter OS in stage IIIC disease (median OS: 33 v 43 months; hazard ratio [HR], 1.40; 95% CI, 1.11 to 1.77) compared with PCS, but not stage IV disease (median OS: 31 v 36 months; HR, 1.16; 95% CI, 0.89 to 1.52). Patients with stages IIIC and IV disease who received NACT were less likely to have ≥ 1 cm postoperative residual disease, an intensive care unit admission, or a rehospitalization (all P ≤ .04) compared with those who received PCS treatment. However, among women with stage IIIC disease who achieved microscopic or ≤ 1 cm postoperative residual disease, NACT was associated with decreased OS (HR, 1.49; 95% CI, 1.01 to 2.18; P = .04). Conclusion Use of NACT increased significantly between 2003 and 2012. In this observational study, PCS was associated with increased survival in stage IIIC, but not stage IV disease. Future studies should prospectively consider the efficacy of NACT by extent of residual disease in unselected patients.
Prostate-Specific Antigen Failure and Risk of Death Within Comorbidity Subgroups Among Men With Unfavorable-Risk Prostate Cancer Treated in a Randomized Trial
Authors: Giacalone Nicholas J. , Wu Jing , Chen Ming-Hui , Renshaw Andrew , Loffredo Marian , Kantoff Philip W. , D’Amico Anthony V. 
Published: September 2016

Purpose Physicians sometimes make management recommendations on the basis of early results from randomized controlled trials (RCTs) relating to reduced prostate-specific antigen (PSA) failure, yet whether this early end point is associated with all-cause mortality (ACM), particularly in men with competing risks, is unknown. Using a validated metric in men treated within the context of an RCT, we aimed to determine whether PSA failure is associated with the risk of ACM stratified by comorbidity score. Patients and Methods Between 1995 and 2001, 206 men with localized (T1b to 2b) intermediate- and high-risk prostate cancer (PC) were randomly assigned to receive radiation therapy or radiation therapy and 6 months of ADT. Cox regression analyses were performed to evaluate whether PSA failure modeled as a time-dependent covariate was associated with an increased risk of ACM among men with Adult Comorbidity Evaluation-27–defined no or minimal versus moderate-to-severe comorbidity adjusting for age, PC prognostic factors, and treatment. Results After a median follow-up of 16.62 years, 156 men (76%) died, 29 of whom (19%) died as a result of PC. PSA failure was associated with an increased ACM risk among men with no or minimal (adjusted hazard ratio, 1.59; 95% CI, 1.03 to 2.46; P = .04), but not moderate or severe comorbidity (adjusted hazard ratio, 1.75; 95% CI, 0.76 to 3.99; P = .19). Conclusion Recommending treatment on the basis of reduced PSA failure observed from early results of RCTs is unlikely to prolong survival in men with moderate-to-severe comorbidity but may prolong survival in men with no or minimal comorbidity, providing evidence to support discussing the early results with these men.