bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing Brain Drug Delivery: The Role of Nanosuspension in Enhancing Therapeutic Efficacy and Bioavailability
Authors: Ghosh Kanchan , Afrose Naureen , Chakraborty Rideb , Hazra Ahana , Bhowmick Pratibha , Bhowmick Mithun 
Published: September 2024

Abstract:
In today’s molecular medicine, delivering therapeutics through the blood-brain barrier
to manage neurological disorders remains a challenge. This is one of the barriers, which could be
potentially solved by nanotechnology; specifically, nanosuspensions are cited to be one of the
most versatile and effective ways. Nanosuspensions of submicron size are a new approach for enhancing
drug solubility, permeability through the blood-brain barrier, and the aspect that contributes
to bioavailability. This work reveals the problems connected with penetration to the blood-
-brain barrier and the notion of therapeutic application utilizing enhanced concepts, outlining the
novelty of nanosuspension. It also provides extensive coverage of formulation methods, stabilizers,
and particle size. Besides, the work also shows the kind of therapeutic agents that are supplied
by nanosuspensions, such as small molecules, nucleic acids, and peptides, as a way of showing the
versatility of the methodology. The focus is especially on the investigations performed in the last
few years with the purpose of improving the therapeutic outcome and the delivery of drug carrier
systems. Compared to other strategies, the work effectively evaluates the bioavailability of several
brain-targeted drugs by means of nanosuspension technology. Therefore, this review suggests the
possibility of using nanosuspensions for therapeutic brain targeting in view of unfulfilled demands
of treating brain tumors, neurodegenerative diseases, and neurological disorders, which marks the
beginning of a new period in the development of pharmaceutical science.
COMPROMISING BETWEEN THE GENERAL AND SPECIFIC IN EAP SYLLABUS DEVELOPMENT IN INDONESIAN CONTEXT
Authors: Jamilah Jamilah 
Published: September 2024

Abstract(Title: Compromising Between the General and Specific in EAP Syllabus Development in Indonesian Context). The quality of a language program is reflected in the syllabus used from which the aim, contents and belief about language instruction are revealed. Syllabuses for English for Academic Purposes in Indonesian universities have been developed, yet they are not quite satisfactory. This article is to explain how to develop a sound syllabus for EAP in Indonesian context, following the steps: context and needs analysis and syllabus planning. Data were collected through triangulated survey employing questionnaires, observation, document study and discussion. Research participants were students, English teachers, and management staff of Yogyakarta State University. Integrated, theme-based syllabus is proposed that includes study skills in higher education as the general theme, which is completed with specific themes related to students’ disciplines. This way enables both general and specific skills of EAP to be included in a single syllabus. Keyword: syllabus, language program, English for academic purposes, instruction.
KEEFEKTIFAN PEMBELAJARAN CIRC DAN MODEL SINEKTIK PADA KETERAMPILAN MENULIS TEKS DESKRIPSI SISWA KELAS VII SMP NEGERI 12 KOTA MAGELANG
Authors: Suratiah Siti , Suroso Suroso 
Published: September 2024

(Title: The Effectiveness of CIRC Learning and Sinectic Models on Description Text Writing Skills Class VII Students of SMPN 12 Magelang). The purpose of this study was to identify comparison of the effectiveness between: (1) the use of CIRC; (2) the use of synectics; and (3) the use of CIRC and synectics methods in the teaching of descriptive text writing skill to junior secondary school students. The experimental design that is used is the pretest-post test control group design with two experimental groups, where treatments of CIRC and synectics methods were applied to each group, and one control group got the conventional learning method. The sample of this study was all of grade 7 students of Junior Secondary School 12 of Magelang Municipality.. The data were collec­ted through assessment rubrics of descriptive text writing skills. The instrument was validated through the content validity with expert judgement. The data were analysed by Anova followed by Scheffe test. The research findings showed that: (1) CIRC method was more effective than conventional teaching method; (2) the synectics method was more effective than conventional learning method; and (3) the CIRC method was more effective than synectics method.Keywords: effectiveness, learning, circ, synectics, descriptive text writing.
Effects of a Digital Therapeutic Adjunct to Eating Disorder Treatment on Health Care Service Utilization and Clinical Outcomes: Retrospective Observational Study Using Electronic Health Records
Authors: Palacios Jorge E , Erickson-Ridout Kathryn K , Paik Kim Jane , Buttlaire Stuart , Ridout Samuel , Argue Stuart , Tregarthen Jenna 
Published: September 2024

Background
The need for scalable solutions facilitating access to eating disorder (ED) treatment services that are efficient, effective, and inclusive is a major public health priority. Remote access to synchronous and asynchronous support delivered via health apps has shown promise, but results are so far mixed, and there are limited data on whether apps can enhance health care utilization.

Objective
This study aims to examine the effects of app-augmented treatment on clinical outcomes and health care utilization for patients receiving treatment for an ED in outpatient and intensive outpatient levels of care.

Methods
Recovery Record was implemented in outpatient and intensive outpatient services in a California-based health maintenance organization. We examined outcomes for eligible patients with ED by comparing clinical and service utilization medical record data over a 6-month period after implementation with analogous data for the control group in the year prior. We used a logistic regression model and inverse-weighted estimates of the probability of treatment to adjust for treatment selection bias.

Results
App-augmented treatment was associated with a significant decrease in emergency department visits (P<.001) and a significant increase in outpatient treatment utilization (P<.001). There was a significantly larger weight gain for patients in low-weight categories (ie, underweight, those with anorexia, or those with severe anorexia) with app-augmented treatment (treatment effect: 0.74, 0.25, and 0.35, respectively; P=.02), with a greater percentage of patients moving into a higher BMI class (P=.01).

Conclusions
Integrating remote patient engagement apps into ED treatment plans can have beneficial effects on both clinical outcomes and service utilization. More research should be undertaken on long-term efficacy and cost-effectiveness to further explore the impact of digital health interventions in ED care.
Sistem Informasi Pengelolaan Stok Berbasis Web Menggunakan Metode RUP Di Warung Madura Perempatan
Authors: Hidayat Pierre Galuh , Suarna Nana , Prihartono Willy 
Published: September 2024

Warung Madura adalah salah satu bentuk bisnis kecil yang memainkan peran penting dalam ekonomi lokal di Indonesia. Permasalahan yang dihadapi oleh pelaku usaha Warung Madura Perempatan menggambarkan perubahan stok meliputi stok masuk ataupun stok keluar menggunakan pengiputan data yang masih menggunakan buku catatan. Tujuan penelitian ini untuk merancang dan mengimplementasikan sistem informasi pengelolaan stok berbasis web untuk Warung Madura Perempatan. Hal ini bertujuan untuk meningkatkan efisiensi dalam mengelola dan memanfaatkan data terkait stok barang. Perubahan tersebut diperlukan untuk menjawab tuntutan penting dalam mengoptimalkan operasional Warung Madura Perempatan dan memperkuat peran strategisnya dalam mendukung ekonomi lokal. Fokus utama penelitian ini adalah untuk mengoptimalkan pengelolaan data stok barang di Warung Madura Perempatan. Metode pengembangan yang digunakan adalah Rational Unified Process (RUP) dengan pemodelan sistem Unified Modelling Language (UML). Selain itu, penelitian ini melibatkan pelatihan bagi pemilik warung. Hal ini dilakukan untuk memastikan bahwa pemilik warung dapat memanfaatkan sistem informasi yang diperbarui dengan efisien. Dengan demikian, diharapkan bahwa penelitian ini akan membantu Warung Madura Perempatan dalam meningkatkan pengelolaan stok, memantau inventaris menu dengan lebih baik. Hasil penelitian ini diharapkan akan memberikan dampak positif dalam mendukung ekonomi lokal, meningkatkan keberlanjutan bisnis Warung Madura Perempatan, dan memberikan dasar yang lebih kuat bagi bisnis kecil serupa dalam komunitas sekitar. Dengan meningkatnya efisiensi operasional, bisnis semacam itu dapat berperan lebih aktif dalam pertumbuhan ekonomi lokal dan memberikan manfaat yang lebih besar bagi masyarakat.
Anthropometric Measurement of Hand Dimension and Their Correlation with Height in Undergraduate Students of a Medical College in Nepal
Authors: Shrestha Subina , KC Sudikshya 
Published: September 2024

Introduction: Height is important for determination of basic energy requirement, standardization and identification. It is also useful for measuring physical capacity and adjusting drug dosages. Sometimes the exact height cannot be determined directly because the patient is unable to stand as a result of neuromuscular weakness, deformities of axial skeleton, loss of lower limbs and in case of amputation. Forensic investigations of skeletal remains also face the problems. Under such circumstances, height can be estimated by hand dimensions.Methods: Hand dimensions and height were measured on 239 medical students in the Department of Anatomy using standard instruments. Among them 120 were females and 119 were males. Correlation between height and hand dimensions was studied. Regression equation was derived for estimation of height from hand dimensions. Results: The correlations between height and hand dimension were statistically significant in both genders (p<0.05). The Pearson correlation between height and hand length was 0.616 and between height and hand breadth was 0.353 in males. Those coefficients for females were 0.706 and 0.198 respectively. Regression equations were formulated for height with hand length in males and females. Conclusion: Height can be predicted from hand length. Hand length showed moderate (males) to strong (females) positive correlation with statistical significance whereas hand breadth showed weak positive correlation with statistical significance.
Clinical use of cone-beam computed tomography in Western Norway: a referral-based retrospective study
Authors: Vollan Marianne L. , Hasselgren Linda Cecilie Kleppe , Shi Xie-Qi , V.  Jonsson Malin 
Published: September 2024

Objective: To elucidate cone-beam computed tomography (CBCT) referral profiles in Western Norway.
Materials and methods: In all, 3,031 referrals to oral- and maxillofacial radiologist were reviewed. Patient data were retrieved retrospectively from electronic charts. The patient’s age, gender, and perceived clinical indication were noted, as well as relevant medical and dental history and whether the referring clinician was a general dentist or held a clinical dental specialty.
Results: A total of 2,680 referrals fulfilled the inclusion criteria (UiB n = 1,471, and TkVestland, n = 1,209). The female:male ratio was 1,427:1,253. Mean age was 33 years – 35 years for females compared to 31 years for males (p < 0.001).
The most common clinical indications were related to impacted teeth (29%), endodontic issues (17%), cleft lip palate (12%), and resorptions (10%). Less common were bone lesions, implant planning, trauma to the teeth or jaws, atypical orofacial pain, and temporo-mandibular joint (TMJ). The patient age-profiles mirrored differences in indications within the cohort. Most referrals were from specialist dentists such as orthodontists, oral surgeons, and endodontists. Interestingly, 543/2,680 (20%) referrals were from general dentists.
Conclusions: Specialist dentists such as orthodontists, oral surgeons, and endodontists refer most patients for clinical indications such as impacted teeth, endodontic issues, and resorptions.
A produção de conhecimentos sobre a relação História da Ciência e Ensino por professores da Educação Básica
Authors: Hidalgo Maycon Raul 
Published: September 2024

Resumo
Buscou-se analisar a produção de conhecimentos sobre as relações História da Ciência-Ensino por Professores da Educação Básica. Para tanto, analisou-se dois periódicos nacionais, identificando os elementos relativos aos autores e áreas de atuação entre 2012-2022. Os dados demonstram que a Física não foi alvo de pesquisas/proposições e que houve um incremento na produção de materiais/relatos de experiência no período. Considera-se necessários estudos que envolvam outros periódicos a fim de compreender se a ausência da Física é uma característica específica dos periódicos em questão ou um padrão na área, além de compreender como os relatos/proposições têm alcançado as salas de aula.
Palavras-chave história da ciência – professor pesquisador – ensino de ciências.

Palavras-chave: História da ciência, Professor pesquisador, Ensino de ciências.

Abstract
This paper aims to analyze the production of knowledge relationships between History of Science and teaching by teachers from elementary school. Thus, has been analyzed two national periodical identifying elements of authors and acting areas between 2012-2022. Data showed physics was not found at research/proposition and that has an increment on material production/experience records at period. As considered necessary new studies with another periodical to understand if physics lack is specifical of that periodic or a standard on area, beyond understanding as experience records/proposition has reached the classroom.

Keywords: History of science, Teacher researcher, Science education.
Operational Employability Model: A Case Study of Graduate Employability in Croatia
Authors: Tecilazić Ana 
Published: September 2024

Abstract

Background
The employability of graduates has become a central topic in higher education policy and research. However, the construct still needs to be clarified.

Objectives
The objective of this paper is to demonstrate the applicability of an operational employability model in analysing the transition from study to work on a sample of graduates in Croatia as part of a larger Eurograduate pilot survey. The model has been rooted in the theories of human capital, cultural and social capital and constructivist educational theory.

Methods/Approach
Factor analysis was applied to reduce the number of measured variables into factor scores that were used as predictors in multiple regression analysis. Cox regression, logistic regression and linear regression were applied to test the employability model.

Results
The results showed that cultural capital, human capital, and bridging social capital, as well as high-impact practises during studies, such as volunteering and internships, have a positive impact on the likelihood of finding employment in less time after graduation in an occupation that vertically matches the qualification, and in a job with a higher monthly income.

Conclusions
The results have shown that cultural capital, human capital, and bridging social capital influence the probability of finding employment in a job that matches the level of qualification in a shorter time after graduation and in a job with a higher monthly income. These findings have practical implications for educators, policymakers, and employers, providing insights into the factors that can enhance graduate employability.
Habitat Suitability Modelling of White-Bellied Pangolin (Phataginus tricuspis) in Oluwa Forest Reserve, Ondo State, Nigeria
Authors: Adeniji Adebola Esther , Ejidike Bernadette Nwandu , Olaniyi Oluwatobi Emmanuel 
Published: September 2024

Abstract
Most endangered species face a significant threat from habitat loss. The destruction and degradation of natural tropical forest across West Africa has likely been the biggest threat to White-bellied Pangolin and has contributed to their decline as they depend on the habitat for different resources like food, water, and shelter. The current study investigated the habitat suitability of white-bellied pangolins in Oluwa Forest Reserve. The presence data of White-bellied pangolin was collected by taking the Global Positioning System (GPS) coordinates of the indirect signs observed. These data, along with the 19 bioclimatic variables, slopes, soil PH, soil texture, distance to rivers, distance to roads, and Normalized Difference Vegetation Index (NDVI), were used to generate habitat suitability maps using MaxEnt software. The MaxEnt analysis showed that out of 781 km2 available for White bellied Pangolin during dry season, 338 km2 was highly suitable, 209 km2 was suitable, 126 km2 was moderately suitable, 65 km2 was less suitable and 44 km2 was not suitable. During the wet season 235 km2 was highly suitable, 225 km2 was suitable, 164 km2 was moderately suitable, 100 km2 was less suitable and 57 km2 was not suitable habitat. The jackknife test of variable contribution revealed that during the dry season, NDVI was the most important predictor variable as measured by the gain produced by a one-variable model, followed by aspects such as distance to the river, slope, distance to the road, and temperature seasonality. During the wet season, the jackknife-cross-validation test showed the highest gain when NDVI was used in isolation. Aspects were found to be the second most important predictor variable as measured by the gain produced by a one-variable model, followed by distance to the road, slope, elevation, and the mean temperature of the wettest quarter.
Comparative analysis of the performance of selected machine learning algorithms depending on the size of the training sample
Authors: Kupidura Przemysław , Kępa Agnieszka , Krawczyk Piotr 
Published: September 2024

Abstract
The article presents an analysis of the effectiveness of selected machine learning methods: Random Forest (RF), Extreme Gradient Boosting (XGB), and Support Vector Machine (SVM) in the classification of land use and cover in satellite images. Several variants of each algorithm were tested, adopting different parameters typical for each of them. Each variant was classified multiple (20) times, using training samples of different sizes: from 100 pixels to 200,000 pixels. The tests were conducted independently on 3 Sentinel-2 satellite images, identifying 5 basic land cover classes: built-up areas, soil, forest, water, and low vegetation. Typical metrics were used for the accuracy assessment: Cohen’s kappa coefficient, overall accuracy (for whole images), as well as F-1 score, precision, and recall (for individual classes). The results obtained for different images were consistent and clearly indicated an increase in classification accuracy with the increase in the size of the training sample. They also showed that among the tested algorithms, the XGB algorithm is the most sensitive to the size of the training sample, while the least sensitive is SVM, which achieved relatively good results even when using training samples of the smallest sizes. At the same time, it was pointed out that while in the case of RF and XGB algorithms the differences between the tested variants were slight, the effectiveness of SVM was very much dependent on the gamma parameter – with too high values of this parameter, the model showed a tendency to overfit, which did not allow for satisfactory results.
Utinga State Park: Producing Ecosystem Services and Mitigating Climate Change
Authors: Velloso Leônidas Pompeu Leão , Reis Cássio Pinho dos , Ferraz Diogo , Silva Elizabete Maria da , Cruz Cláudio Roberto Rodrigues , Rocha Leila 
Published: September 2024

Objective: To qualitatively and quantitatively analyze the importance of a natural asset from an economic and environmental perspective, through a process of valuation and estimation of the economic value of the Camilo Viana Utinga State Park (PEUT).

Theoretical Framework: Based on the concepts of sustainability, climate change and environmental and ecosystem indicators, with a focus on the interrelationship between the environment, society and the economy.

Method: A literature review on the construction of environmental and ecosystem indicators based on 13 variables for the contingent valuation approach and a comparison with the two other valuation approaches: the carbon credit market method and the timber price or benefit-cost method.

Results and Discussion: The results show that keeping the forest standing is much more positive, both in terms of sustainability, climate change mitigation and the economy, based on the values obtained from the three approaches applied.

Research implication: The research has contributed to understanding contemporary economic and environmental challenges, providing support for the construction of more assertive and effective public policies.

Originality/Value: The study proposes a practical approach to evaluating the promotion of ecosystem and environmental services, providing data for the formulation of more effective public policies in urban areas.
Metaverse: an Educational Tool in Business Science Programs
Authors: Vanegas Carolina Vargas , Sánchez Jorge Mario Moreno 
Published: September 2024

Objective: This study aims to explore the perception and experience of the Metaverse in the educational context of Business Sciences, identifying opportunities and challenges in its integration.

Theoretical Framework: Key concepts about the Metaverse and its application in education are presented, highlighting its potential to enhance accessibility, interactivity, and collaboration in learning.

Method: A qualitative methodology is employed, including Likert surveys, semi-structured interviews, and focus groups with students, professors, graduates, and entrepreneurs. Data were analyzed through content analysis and categorized for interpretation.

Results and Discussion: The results show a mostly positive perception of the Metaverse and highlight its ability to generate a dynamic educational experience, but challenges such as accessibility and user experience quality are identified. These findings are discussed in relation to the theoretical framework, indicating implications and areas for improvement.

Research Implications: Practical and theoretical implications of integrating the Metaverse into business education are discussed, emphasizing the need for training and improvement of technological infrastructure. The importance of designing innovative pedagogical strategies to fully leverage the potential of the Metaverse in learning is emphasized.

Originality/Value: This study contributes to the literature by exploring the perception of the Metaverse in a specific educational context. Additionally, it underscores the need to address technical and logistical challenges to ensure successful integration and provides recommendations for enhancing the learning experience.