bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Therapy of Hematologic Malignancies: Toward a Chemotherapy- free Era
Authors: Klener Jr Pavel , Etrych Tomas , Klener Pavel 
Published: October 2017

:Less than 70 years ago, the vast majority of hematologic malignancies were untreatable diseases with fatal prognoses. The development of modern chemotherapy agents, which had begun after the Second World War, was markedly accelerated by the discovery of the structure of DNA and its role in cancer biology and tumor cell division. The path travelled from the first temporary remissions observed in children with acute lymphoblastic leukemia treated with single-agent antimetabolites until the first cures achieved by multi-agent chemotherapy regimens was incredibly short. Despite great successes, however, conventional genotoxic cytostatics suffered from an inherently narrow therapeutic index and extensive toxicity, which in many instances limited their clinical utilization. In the last decade of the 20th century, increasing knowledge on the biology of certain malignancies resulted in the conception and development of first molecularly targeted agents designed to inhibit specific druggable molecules involved in the survival of cancer cells. Advances in technology and genetic engineering enabled the production of structurally complex anticancer macromolecules called biologicals, including therapeutic monoclonal antibodies, antibody-drug conjugates and antibody fragments. The development of drug delivery systems (DDSs), in which conventional drugs were attached to various types of carriers including nanoparticles, liposomes or biodegradable polymers, represented an alternative approach to the development of new anticancer agents. Despite the fact that the antitumor activity of drugs attached to DDSs was not fundamentally different, the improved pharmacokinetic profiles, decreased toxic side effects and significantly increased therapeutic indexes resulted in their enhanced antitumor efficacy compared to conventional (unbound) drugs.:Approval of the first immune checkpoint inhibitor for the treatment of cancer in 2011 initiated the era of cancer immunotherapy. Checkpoint inhibitors, bispecific T-cell engagers, adoptive T-cell approaches and cancer vaccines have joined the platform so far, represented mainly by recombinant cytokines, therapeutic monoclonal antibodies and immunomodulatory agents. In specific clinical indications, conventional drugs have already been supplanted by multi-agent, chemotherapy-free regimens comprising diverse immunotherapy and/or targeted agents. The very distinct mechanisms of the anticancer activity of new immunotherapy approaches not only call for novel response criteria, but might also change fundamental treatment paradigms of certain types of hematologic malignancies in the near future.
Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
Authors: Yumba-Mpanga Arlette , Struck-Lewicka Wiktoria , Wawrzyniak Renata , Markuszewski Marcin , Roslan Marek , Kaliszan Roman , Markuszewski Michał Jan 
Published: October 2017

Background:In regard to urogenital tract cancer studies, an estimated 340,650 new cases and 58,360 deaths from genital system cancer and about 141,140 new cases and 29330 deaths from urinary system were projected to occur in the United States in 2012. The main drawbacks of currently available diagnostic tests constitute the low specificity, costliness and quite high invasiveness.Objective:The main goal of this pilot study was to determine and compare urine metabolic fingerprints in urogenital tract cancer patients and healthy controls.Method:A comparative analysis of the metabolic profile of urine from 30 patients with cancer of the genitourinary system (bladder (n=10), kidney (n=10) and prostate (n=10)) and 30 healthy volunteers as a control group was provided by LC-TOF/MS and GCQqQ/ MS. The data analysis was performed by the use of U-Mann Whitney test or Student’s t-test, principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA).Results:As a result, 33, 43, and 22 compounds were identified as statistically significant in bladder, prostate and kidney cancer, respectively, compared to healthy groups.Conclusion:Diverse compounds such as purine, sugars, amino acids, nucleosides, organic acids which play a role in purine metabolism, in tricarboxylic acid cycle, in amino acid metabolism or in gut microbiota metabolism were identified. Only two metabolites namely glucocaffeic acid and lactic acid were found to be in common in studied three types of cancer.
Metabolomics and Heart Diseases: From Basic to Clinical Approach
Authors: Barba Ignasi , Andrés Mireia , Garcia-Dorado David 
Published: October 2017

Background:The field of metabolomics has been steadily increasing in size for the last 15 years. Advances in analytical and statistical methods have allowed metabolomics to flourish in various areas of medicine. Cardiovascular diseases are some of the main research targets in metabolomics, due to their social and medical relevance, and also to the important role metabolic alterations play in their pathogenesis and evolution. </P><P> Metabolomics has been applied to the full spectrum of cardiovascular diseases: from patient risk stratification to myocardial infarction and heart failure. However - despite the many proof-ofconcept studies describing the applicability of metabolomics in the diagnosis, prognosis and treatment evaluation in cardiovascular diseases - it is not yet used in routine clinical practice. </P><P> Recently, large phenome centers have been established in clinical environments, and it is expected that they will provide definitive proof of the applicability of metabolomics in clinical practice. But there is also room for small and medium size centers to work on uncommon pathologies or to resolve specific but relevant clinical questions. </P><P> Objectives: In this review, we will introduce metabolomics, cover the metabolomic work done so far in the area of cardiovascular diseases.Conclusion:The cardiovascular field has been at the forefront of metabolomics application and it should lead the transfer to the clinic in the not so distant future.
Biomarkers of Atrial Fibrillation in Hypertension
Authors: Tsioufis Costas , Konstantinidis Dimitris , Nikolakopoulos Ilias , Vemmou Evi , Kalos Theodoros , Georgiopoulos Georgios , Vogiatzakis Nikolaos , Ifantis Aris , Konstantinou Konstantinou , Gennimata Vasiliki , Tousoulis Dimitrios 
Published: October 2017

Background:
Atrial fibrillation (AF) is the most frequently encountered cardiac
arrhythmia globally and substantially increases the risk for thromboembolic disease.
Albeit, 20% of all cases of AF remain undiagnosed. On the other hand, hypertension amplifies
the risk for both AF occurrences through hemodynamic and non-hemodynamic
mechanisms and cerebrovascular ischemia. Under this prism, prompt diagnosis of undetected
AF in hypertensive patients is of pivotal importance.

Method:
We conducted a review of the literature for studies with biomarkers that could
be used in AF diagnosis as well as in predicting the transition of paroxysmal AF to sustained
AF, especially in hypertensive patients.

Results:
Potential biomarkers for AF can be broadly categorized into electrophysiological,
morphological and molecular markers that reflect the underlying mechanisms of adverse
atrial remodeling. We focused on P-wave duration and dispersion as electrophysiological
markers, and left atrial (LA) and LA appendage size, atrial fibrosis, left ventricular
hypertrophy and aortic stiffness as structural biomarkers, respectively. The heterogeneous
group of molecular biomarkers of AF encompasses products of the neurohormonal
cascade, including NT-pro BNP, BNP, MR-pro ANP, polymorphisms of the ACE and
convertases such as corin and furin. In addition, soluble biomarkers of inflammation (i.e.
CRP, IL-6) and fibrosis (i.e. TGF-1 and matrix metalloproteinases) were assessed for predicting
AF.

Conclusion:
The reviewed individual biomarkers might be a valuable addition to current
diagnostic tools but the ideal candidate is expected to combine multiple indices of atrial
remodeling in order to effectively detect both AF and adverse characteristics of high risk
patients with hypertension.
Protective Effects of the Caffeine Against Neurodegenerative Diseases
Authors: Tellone Ester , Galtieri Antonio , Russo Annamaria , Ficarra Silvana 
Published: October 2017

Background:
Recent studies and increased interest of the scientific community helped to
clarify the neurological health property of caffeine, one of the pharmacologically active substances
most consumed in the world.

Methods:
This article is a review search to provide an overview on the current state of understanding
neurobiochemical impact of caffeine, focusing on the ability of the drug to effectively counteract several
neurodegenerative disorders such as Alzheimer’s, Parkinson’s, Huntington’s diseases, Multiple
sclerosis and Amyotrophic lateral sclerosis.

Results:
Data collection shown in this review provide a significant therapeutic and prophylactic potentiality
of caffeine which acts on human brain through several pathways because of its antioxidant activity
combined with multiple molecular targets. However, the need to adjust the CF dosage to individuals,
because some people are more sensitive to drugs than others, may constituted a limit to the CF effectiveness.

Conclusion:
What emerges from the complex of clinical and epidemiological studies is a significant CF
potential impact against all neurological disorders. Although, further studies are needed to fully elucidate
the several mechanisms of drug action which in part are still elusive.
Level V Metastasis, a Novel Predicative Factor for Recurrence in N1b Papillary Thyroid Carcinoma
Authors: Wu Yifeng , Li Jianjun , Wu Xianjiang , Dai Lei 
Published: October 2017

Background:
Lymph nodal (LN) metastasis, classified as pN1b, is considered as an independent poor
prognostic factor for Papillary thyroid carcinoma (PTC) patients. However, whether LN metastasis can serve as a
predictive factor for recurrence or disease-free survival of N1b PTC is still plagued by controversy.

Methods:
The N1b PTC patients who underwent total thyroidectomy and unilateral modified radical neck dissection
(MRND) by the same surgical team in Ningbo NO.2 Hospital from March, 1998 to March, 2015 were
included in this study. The clinical and pathological characteristics of each patient were recorded in detail. Univariate
and multivariate Cox proportional hazards regression models were performed to analyze the associations
between clinicopathological characteristics with recurrence. Kaplan–Meier analysis and log-rank test were used
for the analysis of overall RFS and level V metastasis.

Results:
A total of 214 patients were eligible for the final analyses. Of the 214 finally included patients with N1b
PTC, 39 patients were classified with recurrence and 175 without recurrence. The final univariate and multiple
Cox proportional hazards analysis only suggested level V metastasis as the independent predictive factor of N1b
PTC recurrence (HR: 4.11; 95% CI:1.22–11.05, P=0.028). The patients with level V metastasis showed a significantly
lower 10-year RFS rate (P=0.031) as illustrated by Kaplan–Meier analysis and log-rank test.

Conclusion:
Level V metastasis is a novel indicator for tumor recurrence and 10-year RFS in patients with N1b
PTC.
Nano and Microbubble Systems for On-Demand Cancer Drug Delivery
Authors: Budhwani Karim I. , Dettmann Makena A. , Saleh Mansoor N. , Thomas Vinoy 
Published: October 2017

Background:
Chemotherapy, the predominant cancer treatment modality, suffers from
elimination in renal and hepatic systems causing reduced bioavailability and increased toxicity leading
to harmful side effects. Targeted release of formulations encapsulated in protective biocompatible
polymer or polymer-lipid microbubbles can improve bioavailability and potency while reducing
systemic toxicity, resulting in a higher therapeutic index.

Objective:
Double emulsion, the most common method for microbubble fabrication suffers from low
encapsulation efficiency and wide size distributions. In this concise article, we analyze the emergent
coaxial electrospray technique vis-à-vis established double emulsion methods to manufacture biocompatible
polymer microbubbles for targeted drug delivery systems.

Method:
Specifically, we investigate size, morphology, and encapsulation efficiencies of microbubbles
fabricated using double emulsion and coaxial electrospray techniques.

Results:
We found that microbubbles produced via coaxial electrospray displayed higher encapsulation
efficiency and a narrower size distribution.

Conclusion:
Coaxial electrospray is a promising technology with considerably improved size distribution
and encapsulation efficiency; however, reproducibility across facilities and scale remain challenging.
Pengaruh kepemimpinan kepala sekolah dan pelayanan terhadap kepuasan siswa di SMA Negeri Kabupaten Berau
Authors: Yusuf Y. 
Published: October 2017

Penelitian ini bertujuan untuk mengukur (1) pengaruh kepemimpinan kepala sekolah terhadap kepuasan siswa (2) pengaruh pelayanan terhadap kepuasan siswa, (3) pengaruh antara kepemimpinan kepala sekolah dan pelayanan secara bersama-sama terhadap dengan kepuasan siswa. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dengan teknik survei korelasional. Teknik sampling yang digunakan adalah teknik multi stage random sampling. Responden dalam penelitian ini adalah Siswa-siswi SMA Negeri yang berada di Kabupaten Berau dengan populasi sebanyak 3486 siswa/i dan sampel sebanyak 171 siswa/i. Hasil penelitian ini menunjukkan bahwa: Pertama, terdapat pengaruh yang signifikan dari kepemimpinan kepala sekolah terhadap kepuasan siswa. Kedua, terdapat pengaruh yang signifikan dari pelayanan terhadap kepuasan siswa. Ketiga, terdapat pengaruh yang signifikan dari kepemimpinan kepala sekolah dan pelayanan secara bersama-sama terhadap kepuasan siswa.Kata kunci: kepemimpinan kepala sekolah, pelayanan, kepuasan siswa THE EFFECTS OF HEADMASTER'S LEADERSHIP AND SERVICE ON STUDENTS' SATISFACTION IN SENIOR HIGH SCHOOLS IN BERAU REGENCYAbstractThis research aimed to find out (1) the effects of headmaster’s leadership on students’ satisfaction, (2) the effects of service on students’ satisfaction, (3) the effects of headmaster’s leadership and service collectively on students’ satisfaction. The research used quantitative method with correlational survey technique. The sampling technique used was multi stage random sampling. The respondents in this research were Senior High School students in Berau Regency with the population of 3486 students and sample of 171 students. The result of this research shows that: First, there is a significant effect of headmaster’s leadership on students’ satisfaction. Second, there is a significant effect of the service on students’ satisfaction. Third, there is a significant effect of the headmaster’s leadership and service collectively on students’ satisfaction.Keywords: headmaster’s leadership, service, student’s satisfaction
Manajemen pendidik dan tenaga kependidikan di Madrasah Aliyah Negeri Kota Yogyakarta
Authors: Muniroh Jauharotul , Muhyadi Muhyadi 
Published: October 2017

Penelitian ini bertujuan untuk mendeskripsikan sistem manajemen sumber daya manusia terkait tentang perencanaan, perekrutan, penempatan dan pengembangan pendidik dan tenaga kependidikan di Madrasah Aliyah Negeri Kota Yogyakarta. Penelitian ini menggunakan pendekatan kualitatif dengan jenis fenomenologi. Hasil penelitian sebagai berikut (1) perencanaan pendidik dan tenaga kependidikan honorer dengan mengusulkan dari madrasah ke Kantor Wilayah Kementerian Agama, dengan menggunakan tiga analisis yaitu melalui analisis kebutuhan, analisis jabatan, analisis beban kerja, sehingga mampu melakukan analisis kelebihan dan kekurangan; (2) perekrutan pendidik dan tenaga kependidikan honorer dengan menentukan kualifikasi penerimaan sehingga diperoleh pendidik yang berkompeten sesuai dengan mata pelajaran yang diampu; sedangkan tenaga kependidikan honorer yang memiliki skill dan keahlian yang dibutuhkan; (3) penempatan pendidik mengacu pada prinsip the right man on the right place akan tetapi masih terdapat mismatch sebesar 10% antara latar belakang pendidikan dengan mata pelajaran yang diampu; (4) kegiatan pengembangan pendidik dan tenaga kependidikan meliputi pendidikan dan pelatihan berupa bimtek, spiritual quantum learning, studi lanjut, pengembangan diri melalui musyawarah guru mata pelajaran, kegiatan pengajian dan pembinaan. Kata kunci: manajemen, pendidik dan tenaga kependidikan. MANAGEMENT OF TEACHERS AND EDUCATION PERSONNEL IN MADRASAH ALIYAH NEGERI YOGYAKARTAAbstractThis study aims to determine the human resources management system in terms of planning, recruitment, placement and development of teachers and education personnel of madrasah aliyah negeri (MAN) in Yogyakarta. This study is using a qualitative approach with phenomenology type. The results of this study indicate that: (1) planning, honorary teachers and education personnel with the proposal from the bottom up, or from madrassas to the Regional Office of the Ministry of Religion Affairs using three kinds of analysis: needs analysis, job analysis, and workload analysis to be able to analyze the advantages and disadvantages; (2) recruiting honorary teachers and education personnel by determining the requirements for acceptance in order to obtain a competent educator in accordance with the subject matter and honorary education personnel who have the skills and expertise needed; (3) the placement of educators applying the principle of the right man on the right place, although there is a mismatch of 10%; (4) developing activities of teachers and education personnel including education and training in the form of technical assistance, spiritual quantum learning, further studies, self-development through Subject Matter Teacher Forum, pengajian activities, and coaching.Keywords: management, teachers and education personnel
SYNERGISTIC ANTIOXIDANT ACTION OF MURRAYA KOENIGII AND PLUMERIA RUBRA EXTRACTS ENHANCE HEPATOPROTECTIVE EFFICACY AGAINST METHOTREXATE INDUCED LIVER INJURY
Authors: S. Engineer A. , S. Pal , R. Desai K. , N. Highland H. 
Published: October 2017

Objective: The present study was focussed on evaluating the hepatoprotective capacity of a combination of leaf extracts of Murraya koenigii and Plumeria rubra on drug-induced toxicity in mice liver.Methods: Hydromethanolic and aqueous extracts were prepared from the leaves of Murraya koenigii and Plumeria rubra. A combination of these extracts was tested as a dual formulation (DF). The extracts were evaluated for their antioxidant activity and phytochemical content. Healthy adult male mice were treated in five groups, for 30 d: Control (Group I-Untreated), Group II (Methotrexate at 10 mg/kg Body weight, intraperitoneally), Group III (Methotrexate+Silymarin), Group IV (Methotrexate+hydromethanolic extract of DF-250 mg/kg b.w., orally), Group V (Methotrexate+aqueous extract of the DF-250 mg/kg b.w. orally). After treatment, the animals were necropsied. Blood was collected for serum parameters such as alanine transaminase (ALT), Aspartate transaminase (AST) and γ glutamyl transpeptidase (GGT). Further liver function tests like Alkaline phosphatase (ALP), Phosphorylase as well as Oxidative stress parameters like Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT), along with the liver protein and cholesterol content were analyzed.Results: Administration of both the DF extracts significantly ameliorated the methotrexate-induced toxic effects on all the aforementioned biochemical parameters. The hydromethanolic extract showed significant recovery in the liver function tests like ALT (p<0.05) and AST (p<0.001). Antioxidant stress enzymes like SOD (p<0.001) and Catalase (p<0.001) also showed significant recovery after administration of both the extracts. The other parameters assayed also followed the same trend. Although both the extracts showed remarkable hepatoprotection, the hydromethanolic extract was found to be significantly more potent than the aqueous extract.Conclusion: The present study concludes that the Dual formulation of the extracts of Murraya koenigii and Plumeria rubra could be an effective hepatoprotective agent due to the synergistic action of the phytoconstituents of both the plants.
Indicadores de qualidade de enfermagem
Authors: Galhardi Nathalia Malaman , Escobar Eulália Maria Aparecida 
Published: October 2017

Trata-se de uma revisão integrativa que buscou evidenciar e discutir as principais características dos indicadores de qualidade em enfermagem e sua influência na assistência à saúde. Realizou-se a seleção das publicações entre 2003 a 2013 indexadas no LILACS, Base de Dados de Enfermagem e SciELO. Foram analisados 14 artigos e definidas 3 categorias: os principais indicadores de enfermagem utilizados no Brasil; o indicador como ferramenta organizacional; a qualificação da assistência em enfermagem. Os indicadores mais utilizados são relacionados à queda, à perda de sondas, à úlcera por pressão, à não conformidade na administração de medicação e à flebite, entretanto evidenciou-se a importância de não deixar que esses indicadores se tornem únicos. Concluiu-se que, no Brasil, a utilização dos indicadores, apesar de apresentar dificuldades estruturais, culturais e políticas na sua implementação, vem causando impacto importante na assistência à saúde. Palavras-chave: Assistência à saúde. Enfermagem. Indicadores de qualidade em assistência à saúde.
Tratamento da mucosite oral com laser de baixa potência: revisão sistemática de literatura
Authors: Florentino Ana Carolina Andrade , Macedo Dhiancarlo Rocha , David Edielly Fernanda , Carvalho Keller de , Guedes Cizelene do Carmo Faleiros Veloso 
Published: October 2017

Verificar qual o melhor protocolo de aplicação da laserterapia de baixa potência para prevenção e tratamento da mucosite oral químio e rádio induzida. Revisão sistemática de literatura sobre laserterapia na prevenção e tratamento da mucosite oral rádio e químio induzida. Foram utilizadas as indexações “mucositis”, “lowpower laser therapy”, na busca de estudos clínicos randomizados dos últimos 10 anos nas bases de dados de referência: PubMed, LILACS e Cochrane Library. A pesquisa resultou em 16 estudos clínicos randomizados sobre laserterapia de baixa potência, sendo consenso a aplicação 5 vezes por semana, com densidade de energia variada entre 1,3 e 6,0 J/cm². O presente estudo identificou que a laserterapia reduz o tempo de cicatrização e os graus de mucosite oral, apesar de ainda serem necessários mais estudos para definir o protocolo de atuação. Palavras-chave: Estomatite. Mucosite. Quimioterapia. Radioterapia. Terapia a laser de baixa intensidade.