bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Patients at Risk for 3-Day Postdischarge Readmissions, ED Visits, and Deaths
Authors: Agrawal Deepak , Chen Cheng-Bang , Dravenstott Ronald W. , Strömblad Christopher T. B. , Schmid John Andrew , Darer Jonathan D. , Devapriya Priyantha , Kumara Soundar 
Published: May 2016

Background:
Transitional care interventions can be utilized to reduce post-hospital discharge adverse events (AEs). However, no methodology exists to effectively identify high-risk patients of any disease across multiple hospital sites and patient populations for short-term postdischarge AEs.

Objectives:
To develop and validate a 3-day (72 h) AEs prediction model using electronic health records data available at the time of an indexed discharge.

Research Design:
Retrospective cohort study of admissions between June 2012 and June 2014.

Subjects:
All adult inpatient admissions (excluding in-hospital deaths) from a large multicenter hospital system.

Measures:
All-cause 3-day unplanned readmissions, emergency department (ED) visits, and deaths (REDD). The REDD model was developed using clinical, administrative, and socioeconomic data, with data preprocessing steps and stacked classification. Patients were divided randomly into training (66.7%), and testing (33.3%) cohorts to avoid overfitting.

Results:
The derivation cohort comprised of 64,252 admissions, of which 2782 (4.3%) admissions resulted in 3-day AEs and 13,372 (20.8%) in 30-day AEs. The c-statistic (also known as area under the receiver operating characteristic curve) of 3-day REDD model was 0.671 and 0.664 for the derivation and validation cohort, respectively. The c-statistic of 30-day REDD model was 0.713 and 0.711 for the derivation and validation cohort, respectively.

Conclusions:
The 3-day REDD model predicts high-risk patients with fair discriminative power. The discriminative power of the 30-day REDD model is also better than the previously reported models under similar settings. The 3-day REDD model has been implemented and is being used to identify patients at risk for AEs.
Preliminary Effectiveness and Sustainability of Group Aerobic Exercise Program in Patients with Schizophrenia
Authors: Yoon Sol , Ryu Je-Kwang , Kim Chan-Hyung , Chang Jhin-Goo , Lee Hwa-Bock , Kim Do-Hoon , Roh Daeyoung 
Published: May 2016

Abstract
The objective of this study was to examine the feasibility and sustained effect of a group aerobic exercise program in patients with schizophrenia. Twenty-four schizophrenic patients participated in a group-based individually tailored 90-minute outdoor cycling session per week for 3 months with intervention to enhance motivation. Physical health was evaluated by anthropometric measures, cardiorespiratory (CR) fitness, and blood tests. Mental health was assessed on self-esteem, interpersonal relationship, quality of life, and global function. Attrition rate for the exercise program was 8.3%. Exercise program significantly increased participant’s self-esteem, positive relationship, global function, and quality of life. CR fitness significantly improved after 3 months. At the 9-month follow-up, 6 months after program completion, only in interpersonal relationship change the improved effects were maintained. These findings support the feasibility of group aerobic exercise program with high level of adherence and its long-term benefits in positive relationship change.
The interaction of fire and mankind: Introduction
Authors: Scott Andrew C. , Chaloner William G. , Belcher Claire M. , Roos Christopher I. 
Published: May 2016

Fire has been an important part of the Earth system for over 350 Myr. Humans evolved in this fiery world and are the only animals to have used and controlled fire. The interaction of mankind with fire is a complex one, with both positive and negative aspects. Humans have long used fire for heating, cooking, landscape management and agriculture, as well as for pyrotechnologies and in industrial processes over more recent centuries. Many landscapes need fire but population expansion into wildland areas creates a tension between different interest groups. Extinguishing wildfires may not always be the correct solution. A combination of factors, including the problem of invasive plants, landscape change, climate change, population growth, human health, economic, social and cultural attitudes that may be transnational make a re-evaluation of fire and mankind necessary. The Royal Society meeting on Fire and mankind was held to address these issues and the results of these deliberations are published in this volume.
This article is part of the themed issue ‘The interaction of fire and mankind’.
The discovery of fire by humans: a long and convoluted process
Authors: Gowlett J. A. J. 
Published: May 2016

Numbers of animal species react to the natural phenomenon of fire, but only humans have learnt to control it and to make it at will. Natural fires caused overwhelmingly by lightning are highly evident on many landscapes. Birds such as hawks, and some other predators, are alert to opportunities to catch animals including invertebrates disturbed by such fires and similar benefits are likely to underlie the first human involvements with fires. Early hominins would undoubtedly have been aware of such fires, as are savanna chimpanzees in the present. Rather than as an event, the discovery of fire use may be seen as a set of processes happening over the long term. Eventually, fire became embedded in human behaviour, so that it is involved in almost all advanced technologies. Fire has also influenced human biology, assisting in providing the high-quality diet which has fuelled the increase in brain size through the Pleistocene. Direct evidence of early fire in archaeology remains rare, but from 1.5 Ma onward surprising numbers of sites preserve some evidence of burnt material. By the Middle Pleistocene, recognizable hearths demonstrate a social and economic focus on many sites. The evidence of archaeological sites has to be evaluated against postulates of biological models such as the ‘cooking hypothesis' or the ‘social brain’, and questions of social cooperation and the origins of language. Although much remains to be worked out, it is plain that fire control has had a major impact in the course of human evolution.This article is part of the themed issue ‘The interaction of fire and mankind’.
The deforestation story: testing for anthropogenic origins of Africa's flammable grassy biomes
Authors: Bond William , Zaloumis Nicholas P. 
Published: May 2016

Africa has the most extensive C4 grassy biomes of any continent. They are highly flammable accounting for greater than 70% of the world's burnt area. Much of Africa's savannas and grasslands occur in climates warm enough and wet enough to support closed forests. The combination of open grassy systems and the frequent fires they support have long been interpreted as anthropogenic artefacts caused by humans igniting frequent fires. True grasslands, it was believed, would be restricted to climates too dry or too cold to support closed woody vegetation. The idea that higher-rainfall savannas are anthropogenic and that fires are of human origin has led to initiatives to ‘reforest’ Africa's open grassy systems paid for by carbon credits under the assumption that the net effect of converting these system to forests would sequester carbon, reduce greenhouse gases and mitigate global warming. This paper reviews evidence for the antiquity of African grassy ecosystems and for the fires that they sustain. Africa's grassy biomes and the fires that maintain them are ancient and there is no support for the idea that humans caused large-scale deforestation. Indicators of old-growth grasslands are described. These can help distinguish secondary grasslands suitable for reforestation from ancient grasslands that should not be afforested.
This article is part of the themed issue ‘The interaction of fire and mankind’.
At the nexus of fire, water and society
Authors: Martin Deborah A. 
Published: May 2016

The societal risks of water scarcity and water-quality impairment have received considerable attention, evidenced by recent analyses of these topics by the 2030 Water Resources Group, the United Nations and the World Economic Forum. What are the effects of fire on the predicted water scarcity and declines in water quality? Drinking water supplies for humans, the emphasis of this exploration, are derived from several land cover types, including forests, grasslands and peatlands, which are vulnerable to fire. In the last two decades, fires have affected the water supply catchments of Denver (CO) and other southwestern US cities, and four major Australian cities including Sydney, Canberra, Adelaide and Melbourne. In the same time period, several, though not all, national, regional and global water assessments have included fire in evaluations of the risks that affect water supplies. The objective of this discussion is to explore the nexus of fire, water and society with the hope that a more explicit understanding of fire effects on water supplies will encourage the incorporation of fire into future assessments of water supplies, into the pyrogeography conceptual framework and into planning efforts directed at water resiliency.
This article is part of the themed issue ‘The interaction of fire and mankind’.
Global combustion: the connection between fossil fuel and biomass burning emissions (1997–2010)
Authors: Balch Jennifer K. , Nagy R. Chelsea , Archibald Sally , Bowman David M. J. S. , Moritz Max A. , Roos Christopher I. , Scott Andrew C. , Williamson Grant J. 
Published: May 2016

Humans use combustion for heating and cooking, managing lands, and, more recently, for fuelling the industrial economy. As a shift to fossil-fuel-based energy occurs, we expect that anthropogenic biomass burning in open landscapes will decline as it becomes less fundamental to energy acquisition and livelihoods. Using global data on both fossil fuel and biomass burning emissions, we tested this relationship over a 14 year period (1997–2010). The global average annual carbon emissions from biomass burning during this time were 2.2 Pg C per year (±0.3 s.d.), approximately one-third of fossil fuel emissions over the same period (7.3 Pg C, ±0.8 s.d.). There was a significant inverse relationship between average annual fossil fuel and biomass burning emissions. Fossil fuel emissions explained 8% of the variation in biomass burning emissions at a global scale, but this varied substantially by land cover. For example, fossil fuel burning explained 31% of the variation in biomass burning in woody savannas, but was a non-significant predictor for evergreen needleleaf forests. In the land covers most dominated by human use, croplands and urban areas, fossil fuel emissions were more than 30- and 500-fold greater than biomass burning emissions. This relationship suggests that combustion practices may be shifting from open landscape burning to contained combustion for industrial purposes, and highlights the need to take into account how humans appropriate combustion in global modelling of contemporary fire. Industrialized combustion is not only an important driver of atmospheric change, but also an important driver of landscape change through companion declines in human-started fires.This article is part of the themed issue ‘The interaction of fire and mankind’.
Beta regression improves the detection of differential DNA methylation for epigenetic epidemiology
Authors: Triche Timothy J. , Laird Peter W. , Siegmund Kimberly D. 
Published: May 2016

AbstractBackgroundDNA methylation is the most readily assayed epigenetic mark, possessing confirmed relationships with gene expression, imprinting, and chromatin accessibility.Given the increasingly widespread use of DNA methylation microarrays in population-scale epidemiological applications, we sought to determine which methods provided the greatest statistical power to reproducibly detect differences in DNA methylation across various conditions,using publicly available data sets on tissue type and aging.ResultsBeta regression, as proposed originally by Ferrari and Cribari-Neto, yielded more validated hits in each of our comparisons than any other method under consideration, both in a regression setting and in comparisons to two-group tests such as the Wilcoxon-Mann-Whitney, Student t, and Welch t tests.In large cohorts of whole blood samples, we corrected for compositional differences and batch effects, and found that marginal likelihood ratio tests from beta regression models uniformly dominate popular alternatives based on linear models.The superior sensitivity and specificity exhibited by beta regression in epidemiologically relevant cohort sizes corresponded to approximately a 2% increase in sensitivity at the same specificity when compared to linear models fitted on raw beta values (proportion of signal intensity due to the methylated allele), M-values, or rankquantile normalized values.ConclusionsInvestigators should consider beta regression to maximize statistical power in studies of DNA methylation using microarrays.At epidemiologically relevant sample sizes, with typical quality control procedures (compositional and batch effect correction), cross-cohort agreement uniformly favors beta regression over popular alternatives.
The VapBC1 toxin–antitoxin complex fromMycobacterium tuberculosis: purification, crystallization and X-ray diffraction analysis
Authors: Lu Zuokun , Wang Han , Zhang Aili , Tan Yusheng 
Published: May 2016

Mycobacterium tuberculosis, a major human pathogen, encodes at least 88 toxin–antitoxin (TA) systems. Remarkably, more than half of these modules belong to the VapBC family. Under normal growth conditions, the toxicity of the toxin VapC is neutralized by the protein antitoxin VapB. When bacteria face an unfavourable environment, the antitoxin is degraded and the free toxin VapC targets important cellular processes in order to inhibit cell growth. TA systems function in many biological processes, such as in the stringent response, in biofilm formation and in drug tolerance. To explore the structure of the VapBC1 complex, the toxin VapC1 and the antitoxin VapB1 were separately cloned, co-expressed and crystallized. The best crystal was obtained using a crystallization solution consisting of optimized solution with commercial sparse-matrix screen solutions as additives. The crystal diffracted to a resolution of 2.7 Å and belonged to space groupP21, with unit-cell parametersa= 59.3,b= 106.7,c = 250.0 Å, β = 93.75°.
Competencies for entrepreneurship as a career option in a challenging employment environment
Authors: Pérez-López María Carmen , González-López María José , Rodríguez-Ariza Lázaro 
Published: May 2016

Purpose
– Entrepreneurship is an increasing relevant career option in the present labour market, which is complex and ever less rigidly structured. In this context, individuals need to develop a range of competencies, and one of major importance is resilience, defined as the ability to cope with difficult situations and to adapt to adverse environments. Taking into account the theory of planned behaviour, the purpose of this paper is to determine the direct relationship between resilience and entrepreneurship as a career option, and to analyse the mediating role of resilience in the relation between entrepreneurial intention (EI) and underlying factors such as attitudes towards entrepreneurship, social norms and self-efficacy.

Design/methodology/approach
– Using structural equation modelling, the authors studied a sample of 1,251 business students at a Spanish university.

Findings
– The results obtained reveal positive and significant relationships between resilience and EI, and highlight the mediating role played by resilience.

Practical implications
– Since resilience is a competency that can be developed, and taking into account the positive relationship observed between antecedents of EI and resilience, training activities should be designed in which these factors are jointly stimulated. In addition, the findings highlight the need for institutional actions to reinforce the social esteem of the entrepreneur.

Originality/value
– This paper contributes a valuable and relatively unexplored line of research concerning the relationship between one of the components of psychological capital and the choice of an entrepreneurial career.
Addressing perceptions of opiate-using prisoners to take-home naloxone: findings from one English region
Authors: Sondhi Arun Charles 
Published: May 2016

Purpose– The purpose of this paper is to understand prisoner perceptions on being trained and having received take-home naloxone (THN) kits once released from prison back into the community, in order to prevent an opiate-related overdose.Design/methodology/approach– A survey was run of all prisoners receiving THN training across ten prisons in one English region. In total, 142 prisoners were surveyed out of 206 (69 per cent) being trained in THN across the ten prisons. Five focus groups (n=26) with prisoners were conducted across four remand and one open prison that included discussions on THN within a range of topics. Discussions were recorded using short-hand and the data were subsequently thematically interpreted using visual mapping techniques.Findings– The survey highlighted a high degree of exposure amongst prisoners to overdose either directly (54 per cent) or having witnessed another person’s overdose (73 per cent). For prisoners who had overdosed, only a minority (38 per cent) were taken to hospital by an ambulance. In total, 81 per cent of prisoners surveyed also expressed little or no knowledge about THN prior to training. Prisoners were resistant to THN as an intervention resulting from this lack of prior knowledge. Focus group interviews suggested that there was a confused and mixed message in providing a harm reduction initiative within the context of recovery-orientated treatment. Prisoners also exhibited name confusion with other drugs (naltrexone) and there was some degree of resistance to being trained based on perceived side-effects brought on by its administration. Prisoners were also acutely aware of official agency perceptions (e.g. police) if seen to be in possession of THN kits.Practical implications– The distribution of THN within a custodial setting requires consideration of wider marketing approaches to address levels of confusion and misapprehension amongst prisoners.Originality/value– The study is one of the few focused on THN based on a UK prison environment.
Developing Alberta’s greenhouse gas offset system within Canadian and international policy contexts
Authors: Swallow Brent M. , Goddard Thomas W. 
Published: May 2016

Purpose
This paper aims to track the development of climate policy in the province of Alberta, Canada, particularly the province’s unique greenhouse gas emission offset mechanism. The analysis shows how the policy has influenced, and been influenced by, policy processes at the national and international levels.

Design/methodology/approach
The paper begins with an analytical framework that recognizes different types of influence between international, national and provincial climate policy processes. That framework is used to structure a review of four historical periods of climate policy change: prior to 1992, 1992 to 2002, 2002 to 2012 and between 2012 and mid-2015.

Findings
The analysis illustrates the interplay between the Alberta approach to climate policy and the international and national policy contexts. A period of intense policy conflict between Canada’s federal and provincial governments led to a situation in which the Alberta Government sought to lead rather than follow national policy. Subsequent periods have seen the Canadian national government oscillate between following the lead of Alberta or the USA.

Research limitations/implications
Rather than national and international policies simply setting the context for Alberta’s policy, the paper identifies multiple flows of influence between the three levels of governance. The results illustrate the need to consider forward and backward flows of influence between the different levels of government that set climate change policies. Elements of several models of policy change are supported.

Practical implications
The Alberta climate mitigation policy has many elements that can be effective in reducing carbon emissions in a way that is both flexible and predictable. These elements are of interest to other jurisdictions. Other elements of the current policy, however, limit its effectiveness in reducing emissions. More concerted policy action is needed to mitigate carbon emissions in Alberta for Canada to meet its agreed targets.

Originality/value
No other paper has tracked the historical evolution of climate policy at the provincial/state level in a way that clarifies the forward and backward linkages with national and international policy.
Negotiating stakeholder participation in the Ghana national climate change policy
Authors: Lawson Elaine Tweneboah 
Published: May 2016

PurposeStakeholder consultation and participation are central to the climate change policymaking process. The purpose of this paper is to assess the level of stakeholder participation in the Ghana National Climate Change Policy. It examines the actors in the policy space and the negotiations and tradeoffs made during the policymaking process. Finally, it outlines the steps undertaken to make the process participatory and consultative.Design/methodology/approachA qualitative method has been used for this paper. The research design involves a review of relevant literature on Ghana’s climate change regime, meeting reports and key informant interviews.FindingsThe findings indicate that the processes the policy underwent had extensive stakeholder participation. An uptake of evidence was from existing impact and vulnerability assessments, the first and second communication to the United Nations Framework Convention on Climate Change (UNFCCC), scientific and research documents and expert knowledge. Key actors were identified and involved right from the beginning of the policymaking process. Although stakeholder participation was time-consuming, expensive and elongated, the policy process was vital for buy-in and ownership. The results also identified the need to include more stakeholders at the sub-regional levels in policymaking.Originality/valueThe study is the first of its kind detailing stakeholder participation in the climate change policy process in Ghana. It forms a good basis for comparative studies with similar policies in other countries. Thus, this paper fills an identified gap of the need to document climate change policymaking processes.