bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating Total Corneal Astigmatism From Anterior Corneal Data
Authors: Næser Kristian , Savini Giacomo , Bregnhøj Jesper Flethøj 
Published: May 2017

Purpose:
To determine keratometric astigmatism (KA), posterior corneal astigmatism (PCA), and total corneal astigmatism (TCA) in 951 normal eyes, to establish a model for estimating TCA from anterior corneal data, and to test this method in a new group of eyes with toric intraocular lenses (TIOLs).

Methods:
We used a Pentacam HR (high-resolution) Scheimpflug camera to determine KA, PCA, and TCA in 951 normal eyes. A model to estimate TCA from anterior corneal data was evaluated by the difference (=error) between the measured TCA and the estimated value. The model was tested in 40 eyes with TIOLs.

Results:
KA, TCA, and PCA averaged 1.06 (±0.85) D, 1.05 (±0.83) D, and 0.33 (±0.17) D. The error of the model to estimate TCA averaged zero with an SD of ±0.21 D. Application of this model and of direct Pentacam TCA measurements in TIOL calculation gave similar results, namely a slight reduction of overcorrection in with-the-rule astigmatism, but an eradication of undercorrection in against-the-rule astigmatism.

Conclusions:
It was possible to estimate TCA accurately from anterior corneal data with a new formula. However, application of both this model on keratometric data and of direct Pentacam measurements in a group of 40 eyes with TIOLs did not completely eradicate the refractive error in TIOL calculation. More studies comparing Pentacam TCA and refractive astigmatism are required.
Substance Use Among Nurses and Nursing Students
Authors: Strobbe Stephen , Crowley Melanie 
Published: May 2017

Abstract
Alcohol and other substance use by nurses potentially places patients, the public, and nurses themselves at risk for serious injury or death. Nursing students are also at risk for problems related to substance use. When viewed and treated as a chronic medical illness, treatment outcomes for substance use disorders are comparable with those of other diseases and can result in lasting benefits. Professional monitoring programs that employ an alternative-to-discipline approach have been shown to be effective in the treatment of health professionals with substance use disorders and are considered a standard for recovery, with high rates of completion and return to practice. It is the position of the Emergency Nurses Association and the International Nurses Society on Addictions that 1. health care facilities provide education to nurses and other employees regarding alcohol and other drug use and establish policies, procedures, and practices to promote safe, supportive, drug-free workplaces; 2. health care facilities and schools of nursing adopt alternative-to-discipline approaches to treating nurses and nursing students with substance use disorders, with stated goals of retention, rehabilitation, and reentry into safe, professional practice; 3. drug diversion, in the context of personal use, is viewed primarily as a symptom of a serious and treatable disease and not exclusively as a crime; and 4. nurses and nursing students are aware of the risks associated with substance use, impaired practice, and drug diversion and have the responsibility and means to report suspected or actual concerns.
Diffusion Restriction in the Optic Nerve and Retina in Patients With Carotid Occlusion
Authors: Vicente Mikel , Serrano Alba R. , Falgàs Neus , Borrego Sergio , Amaro Sergio , Cardenal Carlos , Urra Xabier 
Published: May 2017

Objectives:
The primary role of magnetic resonance imaging (MRI) in a patient with suspected optic neuropathy is to rule out nonischemic disorders, and many of the reported cases of ischemic optic neuropathy with positive neuroimaging are atypical forms of ischemic optic neuropathy. We studied the role of diffusion-weighted images of MRI in patients with ocular ischemia.

Methods:
We describe the clinical, fundoscopic and neuroimaging characteristics of 3 patients with definite ocular ischemia related to occlusion of the carotid artery.

Results:
Diffusion-weighted images revealed typical changes of ischemia in a “cup of wine” shape, with increased signal intensity in diffusion-weighted imaging and a decrease in diffusivity in the apparent diffusion coefficient maps. A repeated MRI 8 days after presentation showed persistent hypointensity in apparent diffusion coefficient maps in 1 of the patients.

Conclusions:
Patients with ocular ischemia can disclose typical ischemic changes on dedicated brain MRI sequences. These findings might be beneficial in the diagnosis of patients with acute vision loss.
Early Neurological Deterioration During Alteplase Infusion for Acute Ischemic Stroke
Authors: Safouris Apostolos , Kargiotis Odysseas , Magoufis Georgios , Katsanos Aristeidis H. , Stamboulis Eleftherios , Tsivgoulis Georgios 
Published: May 2017

Introduction:
Recognizing new-territory ischemic stroke as an uncommon complication of intravenous thrombolysis is very important as it can lead to neurological deterioration during tissue-plasminogen-activator infusion.

Case Report:
We report a case of an 80-year-old patient that has been treated with intravenous thrombolysis for right middle cerebral artery acute ischemic stroke. During infusion he had an abrupt neurological deterioration that proved to be a distal embolization of an asymptomatic non-occluding tip-of-the-basilar thrombus to the territory of left posterior cerebral artery that has been missed by the treating neurologist and radiologist in the pretreatment computed tomography angiography. In the thrombectomy that followed, only the right carotid artery has been catheterized and only the right middle cerebral artery was successfully recanalized, leaving the left posterior cerebral artery occlusion untreated.

Conclusions:
This case highlights that the use of thrombectomy in clinical practice provides an effective therapeutic option for large vessel occlusion in this setting. However, high clinical suspicion for this rare complication is mandatory to proceed to correct diagnosis and treatment.
Right Hand Weakness and Headache During Ascent to Mount Everest
Authors: Kim Jeong Hee , Kim Soo Jeong , Kim Hahn Young 
Published: May 2017

Introduction:
The increasing popularity of trekking in alpine regions has drawn attention to high altitude-associated health concerns.

Case Report:
Here, we report a case of cerebral venous infarction as a consequence of a hypercoagulable state induced by secondary polycythemia as an adaptation to high altitude.

Conclusions:
When patients present focal neurological symptoms such as hemiparesis in addition to symptoms of acute mountain sickness or high-altitude cerebral edema such as headache, nausea, vomiting, and dizziness, cerebral venous infarction should be considered.
Recurrent Optic Neuritis Associated With MOG Antibody Seropositivity
Authors: Chang Thashi , Waters Patrick , Woodhall Mark , Vincent Angela 
Published: May 2017

Introduction:
Optic neuritis (ON) can be the first manifestation of autoimmune central nervous system diseases such as multiple sclerosis and neuromyelitis optica, but it can also occur as an isolated monophasic or relapsing disease. A proportion of these patients have antibodies against myelin oligodendrocyte glycoprotein (MOG). We report a case of recurrent ON with MOG antibodies in a South Asian patient.

Case Report:
A 50-year-old Sri Lankan female with a previous history of 2 episodes of steroid-responsive ON presented with a 20/120 visual impairment of her right eye. On examination on admission, visual acuity was noted to be 20/30 on the left and visual evoked potentials were prolonged bilaterally, but all other neurological investigations including screening tests for infections and vasculitis were unremarkable. AQP4 antibodies were negative but MOG antibodies were positive. She responded to intravenous and long-term steroids combined with mycophenolate mofetil, but relapsed when steroids were discontinued. She has been relapse free on low-dose steroids and mycophenolate for 2 years.

Conclusions:
Recurrent ON occurs in association with MOG antibodies distinct from neuromyelitis optica and multiple sclerosis, and may require steroid-based immunosuppression to maintain remission. This case report from South Asia adds to map the worldwide occurrence of MOG antibody disease.
Utility of Ultrasound Guidance for Central Venous Access in Children
Authors: He Chen , Vieira Rebecca , Marin Jennifer R. 
Published: May 2017

Background
Placement of a central venous catheter (CVC) in a pediatric patient is an important skill for pediatric emergency medicine physicians but can be challenging and time consuming. Ultrasound (US) guidance has been shown to improve success of central line placement in adult patients.

Objectives
This article aims to review the literature and evaluate the benefit of US guidance in the placement of CVCs, specifically in pediatric emergency department patients, and to review the procedure.

Results
Four meta-analyses of US-guided CVC placement in adult patients concluded that US guidance reduces placement failure, decreases complications, and decreases the need for multiple attempts. Two studies in the emergency department setting support these conclusions. Pediatric-specific data related to US-guided CVC placement include data suggesting a benefit with US guidance, as well as data indicating no difference in outcome measures when US guidance is used compared with the landmark technique.

Conclusions
The evidence surrounding US-guided CVC insertion supports its use in adult patients. Pediatric-specific literature is sparse and includes mixed results. As more pediatric emergency physicians adopt the use of point-of-care US, we expect an increase in data supporting its use for CVC placement in pediatric emergency department patients.
Diaper Slit Perineal Bag Urine Sampling
Authors: Naimer Sody A. 
Published: May 2017

ObjectiveMany indications justifiably drive the pediatrician to request a urine sample in order to assess the health status of the incontinent baby or infant. Urine collection by means of an adhesive perineal bag is the most widely used in children who do not control urine emission, despite its inaccurate reflection of bacteriuria. We suggest a novel technique to immediately visualize the micturition event upon occurrence, in attempt to shorten waiting times and exhausting checking and rechecking opaque diapers in order to determine whether the desired sample has finally been delivered.MethodsThe perineal urine collection bag is pulled through a vertical slit created in the front of the disposable diaper. The bag is now visible at all times.ResultsIn general, waiting times appear shortened since the implementation of this practice. Since the adoption of this technique at a number of our clinics, we have not experienced bag displacement as was previously experienced. Forgoing the need to manipulate the diaper and repeatedly awakening irritable infants was gladly welcomed by parents.ConclusionsWidespread adoption of the diaper slit technique seems a promising procedure enhancing comfort and facilitating the process of obtaining a urine sample in the incontinent child. Assumptions that this procedure actually shortens waiting times and raises the success rates of sample retrieval remain to be proven by formal comparative trials.
Changing Dynamics of HIV Transmission in Côte d'Ivoire: Modeling Who Acquired and Transmitted Infections and Estimating the Impact of Past HIV Interventions (1976–2015)
Authors: Maheu-Giroux Mathieu , Vesga Juan F. , Diabaté Souleymane , Alary Michel , Baral Stefan , Diouf Daouda , Abo Kouamé , Boily Marie-Claude 
Published: May 2017

Introduction:
Understanding the impact of past interventions and how it affected transmission dynamics is key to guiding prevention efforts. We estimated the population-level impact of condom, antiretroviral therapy (ART), and prevention of mother-to-child transmission activities on HIV transmission and the contribution of key risk factors on HIV acquisition and transmission.

Methods:
An age-stratified dynamical model of sexual and vertical HIV transmission among the general population, female sex workers (FSW), and men who have sex with men was calibrated to detailed prevalence and intervention data. We estimated the fraction of HIV infections averted by the interventions, and the fraction of incident infections acquired and transmitted by different populations over successive 10-year periods (1976–2015).

Results:
Overall, condom use averted 61% (95% credible intervals: 56%–66%) of all adult infections during 1987–2015 mainly because of increased use by FSW (46% of infections averted). In comparison, ART prevented 15% (10%–19%) of adult infections during 2010–2015. As a result, FSW initially (1976–1985) contributed 95% (91%–97%) of all new infections, declining to 19% (11%–27%) during 2005–2015. Older men and clients mixing with non-FSW are currently the highest contributors to transmission. Men who have sex with men contributed ≤4% transmissions throughout. Young women (15–24 years; excluding FSW) do not transmit more infections than they acquired.

Conclusions:
Early increases in condom use, mainly by FSW, have substantially reduced HIV transmission. Clients of FSWs and older men have become the main source of transmission, whereas young women remain at increased risk. Strengthening prevention and scaling-up of ART, particularly to FSW and clients of female sex workers, is important.
Multiparametric Magnetic Resonance Imaging of the Prostate
Authors: Fedorov Andriy , Vangel Mark G. , Tempany Clare M. , Fennessy Fiona M. 
Published: May 2017

Objectives
The aim of this study was to evaluate the repeatability of a region of interest (ROI) volume and mean apparent diffusion coefficient (ADC) in standard-of-care 3 T multiparametric magnetic resonance imaging (mpMRI) of the prostate obtained with the use of endorectal coil.

Materials and Methods
This prospective study was Health Insurance Portability and Accountability Act compliant, with institutional review board approval and written informed consent. Men with confirmed or suspected treatment-naive prostate cancer scheduled for mpMRI were offered a repeat mpMRI within 2 weeks. Regions of interest corresponding to the whole prostate gland, the entire peripheral zone (PZ), normal PZ, and suspected tumor ROI (tROI) on axial T2-weighted, dynamic contrast-enhanced subtract, and ADC images were annotated and assessed using Prostate Imaging Reporting and Data System (PI-RADS) v2. Repeatability of the ROI volume for each of the analyzed image types and mean ROI ADC was summarized with repeatability coefficient (RC) and RC%.

Results
A total of 189 subjects were approached to participate in the study. Of 40 patients that gave initial agreement, 15 men underwent 2 mpMRI examinations and completed the study. Peripheral zone tROIs were identified in 11 subjects. Tumor ROI volume was less than 0.5 mL in 8 of 11 subjects. PI-RADS categories were identical between baseline-repeat studies in 11/15 subjects and differed by 1 point in 4/15. Peripheral zone tROI volume RC (RC%) was 233 mm3 (71%) on axial T2-weighted, 422 mm3 (112%) on ADC, and 488 mm3 (119%) on dynamic contrast-enhanced subtract. Apparent diffusion coefficient ROI mean RC (RC%) were 447 × 10−6 mm−2/s (42%) in PZ tROI and 471 × 10−6 mm−2/s (30%) in normal PZ. Significant difference in repeatability of the tROI volume across series was observed (P < 0.005). The mean ADC RC% was lower than volume RC% for tROI ADC (P < 0.05).

Conclusions
PI-RADS v2 overall assessment was highly repeatable. Multiparametric magnetic resonance imaging sequences differ in volume measurement repeatability. The mean tROI ADC is more repeatable compared with tROI volume in ADC. Repeatability of prostate ADC is comparable with that in other abdominal organs.
‘Not to escape the world but to join it’: responding to climate change with imagination not fantasy
Authors: Davison Andrew 
Published: May 2017

The work of climate scientists, demonstrating human-driven climate change, has not provoked the widespread and far-reaching changes to human behaviour necessary to avert potentially catastrophic environmental trajectories. This work has not yet sufficiently been able to engage the individual and collective imagination. Drawing on Samuel Taylor Coleridge (1772–1834) and Iris Murdoch (1919–1999), we can distinguish two modes under which the human imagination can operate: in Murdoch's terms, these are ‘imagination’ and ‘fantasy’. To relate imaginatively is to be willing to allow one's internal image of the world to be changed by what one encounters, while an outlook characterized by fantasy relates to the world as one would wish it were, rather than how it actually is. Fantasy, therefore, operates not only among those who deny climate change, but also among those who entertain the promise of a technological solution too optimistically. An imaginative outlook, by contrast, evaluates actions and patterns of behaviour in terms of their relation to a wider whole. This is necessary for providing the degree of agency required to step out of a cycle of ever accelerating production, which is explored in terms of an analogy to a discussion of revenge and forgiveness from Hannah Arendt (1906–1975). Ultimately, the need to engage the imagination is an opportunity as well as a challenge. To live imaginatively is fulfilling, and that is precisely what the challenges of climate change require.This article is part of the themed issue ‘Material demand reduction’.
Towards environmentally sustainable human behaviour: targeting non-conscious and conscious processes for effective and acceptable policies
Authors: Marteau Theresa M. 
Published: May 2017

Meeting climate change targets to limit global warming to 2°C requires rapid and large reductions in demand for products that most contribute to greenhouse gas (GHG) emissions. These include production of bulk materials (e.g. steel and cement), energy supply (e.g. fossil fuels) and animal source foods (particularly ruminants and their products). Effective strategies to meet these targets require transformative changes in supply as well as demand, involving changes in economic, political and legal systems at local, national and international levels, building on evidence from many disciplines. This paper outlines contributions from behavioural science in reducing demand. Grounded in dual-process models of human behaviour (involving non-conscious and conscious processes) this paper considers first why interventions aimed at changing population values towards the environment are usually insufficient or unnecessary for reducing demand although they may be important in increasing public acceptability of policies that could reduce demand. It then outlines two sets of evidence from behavioural science towards effective systems-based strategies, to identify interventions likely to be effective at: (i) reducing demand for products that contribute most to GHG emissions, mainly targeting non-conscious processes and (ii) increasing public acceptability for policy changes to enable these interventions, targeting conscious processes.This article is part of the themed issue ‘Material demand reduction’.
Demanding stories: television coverage of sustainability, climate change and material demand
Authors: Smith Joe 
Published: May 2017

This paper explores the past, present and future role of broadcasting, above all via the medium of television, in shaping how societies talk, think about and act on climate change and sustainability issues. The paper explores these broad themes via a focus on the important but relatively neglected issue of material demand and opportunities for its reduction. It takes the outputs and decision-making of one of the world's most influential broadcasters, the BBC, as its primary focus. The paper considers these themes in terms of stories, touching on some of the broader societal frames of understanding into which they can be grouped. Media decision-makers and producers from a range of genres frequently return to the centrality of ‘story’ in the development, commissioning and production of an idea. With reference to specific examples of programming, and drawing on interviews with media practitioners, the paper considers the challenges of generating broadcast stories that can inspire engagement in issues around climate change, and specifically material demand. The concluding section proposes actions and approaches that might help to establish material demand reduction as a prominent way of thinking about climate change and environmental issues more widely.
This article is part of the themed issue ‘Material demand reduction’.
Widespread Inter-Chromosomal Epistasis Regulates Glucose Homeostasis and Gene Expression
Authors: Chen Anlu , Liu Yang , Williams Scott M. , Morris Nathan , Buchner David A. 
Published: May 2017

AbstractThe relative contributions of additive versus non-additive interactions in the regulation of complex traits remains controversial. This may be in part because large-scale epistasis has traditionally been difficult to detect in complex, multi-cellular organisms. We hypothesized that it would be easier to detect interactions using mouse chromosome substitution strains that simultaneously incorporate allelic variation in many genes on a controlled genetic background. Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to additive effects. These epistatic interactions typically resulted in trait values returning to the levels of the parental CSS host strain. Due to the large epistatic effects, analyses that did not account for interactions consistently underestimated the true effect sizes due to allelic variation or failed to detect the loci controlling trait variation. These studies demonstrate that epistatic interactions are a common feature of complex traits and thus identifying these interactions is key to understanding their genetic regulation.
High-density super-resolution microscopy with an incoherent light source and a conventional epifluorescence microscope setup
Authors: Prakash Kirti 
Published: May 2017

We report that single-molecule superresolution microscopy can be achieved with a conventional epifluorescence microscope setup and a Mercury arc lamp. The configuration termed as Omnipresent Localisation Microscope (OLM), is an extension of Single Molecule Localisation Microscopy (SMLM) techniques and allows single molecules to be switched on and off (’blinking’), detected and localised. The use of a short burst of deep blue excitation can be further used to reactivate the blinking, once the blinking process has slowed or stopped. A resolution of 90 nm is achieved on test specimens (mouse and amphibian meiotic chromosomes). Finally, for the first time, we demonstrate that STED and OLM can be performed on the same biological sample using a simple imaging buffer. It is hoped that such a correlative imaging will provide a basis for a further enhanced resolution.Scope of the findingsDespite ten years of development, superresolution microscopy is still limited to relatively few microscopy and optics groups. This is mainly due to the significant cost of the superresolution microscopes which require high-quality lasers, high NA objective lens, a very sensitive camera, a highly precise microscope stage, and a complex post-acquisition data reconstruction and analysis. We present results that demonstrate the possibility to obtain nanoscale resolution images using a conventional microscope and an incoherent light source. We show an easyto-follow protocol that every biologist can implement in the laboratory. We hope that this finding will help any scientist to generate high-density super-resolution images even with limited budget. Lastly, the new photophysical observations reported here will pave the way for more in-depth investigations on excitation, photobleaching and photoactivation of a fluorophore.