bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen
Authors: Robertson Anne L. , Ogryzko Nikolay V. , Henry Katherine M. , Loynes Catherine A. , Foulkes Matthew J. , Meloni Marco M. , Wang Xingang , Ford Christopher , Jackson Malcolm , Ingham Philip W. , Wilson Heather L. , Farrow Stuart N. , Solari Roberto , Flower Roderick J. , Jones Simon , Whyte Moira K. B. , Renshaw Stephen A. 
Published: April 2016

ABSTRACT
Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of chronic inflammatory diseases, which respond poorly to current treatments. It is therefore important to develop drug discovery strategies that can identify new therapeutics specifically targeting neutrophils, either by promoting their clearance or by preventing their recruitment. Our recent in vivo chemical genetic screen for accelerators of inflammation resolution identified a subset of compounds sharing a common chemical signature, the bicyclic benzopyrone rings. Here, we further investigate the mechanisms of action of the most active of this chemical series, isopimpinellin, in our zebrafish model of neutrophilic inflammation. We found that this compound targets both the recruitment and resolution phases of the inflammatory response. Neutrophil migration towards a site of injury is reduced by isopimpinellin and this occurs as a result of PI3K inhibition. We also show that isopimpinellin induces neutrophil apoptosis to drive inflammation resolution in vivo using a new zebrafish reporter line detecting in vivo neutrophil caspase-3 activity and allowing quantification of flux through the apoptotic pathway in real time. Finally, our studies reveal that clinically available ‘cromones’ are structurally related to isopimpinellin and have previously undescribed pro-resolution activity in vivo. These findings could have implications for the therapeutic use of benzopyrones in inflammatory disease.
Responses to environmental and socio-economic changes in the Karangwangi traditional agroforestry system, South Cianjur, West Java
Authors: ISKANDAR JOHAN , ISKANDAR BUDIAWATI SUPANGKAT , PARTASASMITA RUHYAT 
Published: April 2016

Iskandar J, Iskandar BS, Partasasmita R. 2016. Responses to environmental and socio-economic changes in theÂ Karangwangi traditional agroforestry system, South Cianjur, West Java. Biodiversitas 17: 332-341. In the past, the swidden agriculturesystem (huma) was dominant in village frontiers of West Java; including in the Karangwangi Village of Cidaun Sub-district, Cianjur District, West Java Province. Culturally, each Karangwangi household owned a right to cultivate upland rice (huma) by felling mature forest (leuweung). Moreover, the land was planted by upland rice and other annual crops, such as corn, cassava, cucumber, and various beans. After harvesting rice and other annual crops, the land was fallowed and transformed into secondary forest (reuma) through natural succession. Moreover, the mature secondary forestÂ (reuma kolot) could be opened for rice planting again in the following year or fallowed for more than 3-5 years. People will shift to another piece of mature secondary forest for rice planting. Today, because ofÂ increasing population, decreasing forests, and increasing market economic penetration, the Karangwangi people have predominantlyÂ practiced the swidden farming in the non-forest instead of the forest. The forests had culturally been converted to traditional agroforestry systems, such as mixed-garden (kebon tatangkalan),Â Â and homegarden (pekarangan). This paper discusses the process of evolution of the swidden farming and innovatory cultural practice among the Karangwangi community, South Cianjur, West Java, in management of the traditional agroforestry systems which have been dynamically affected by ecological and socio-economic changes. Four parts are presented in this paper. In part one, we account for the Karangwangi people used to practice the swidden farming in the forest when the forest area that was still abundant. In part two, we discuss a focus on process of the evolution of the swidden farming, transformed to the traditional agroforestry systems In part three, we elaborate on some changes of the traditional agroforestry system and responses to environmental changes. In part four, it is summarized and inferred of the paper. Based on this study, it can be inferred that byÂ developing innovatory cultural practice, Karangwangi people of South Cianjur, West Java have tended to success to evolve their swidden farming to new condition of the traditional agroforestry systems in sustainable way, despite population growth, the depletion of the forests, and intensive market economic penetration.
Prevalence of pelvic floor symptoms in female patients attending the two-week wait clinic with suspected colorectal cancer
Authors: Bennett J , Greenwood A , Durdey P , Glancy D 
Published: April 2016

IntroductionThe aim of this study was to establish the prevalence of pelvic floor symptoms in women referred to a colorectal two-week wait (2WW) clinic with suspected colorectal cancer.MethodsA questionnaire assessing faecal incontinence (FI) (Wexner score) and obstructed defecation syndrome (ODS) (Renzi score) was offered to 98 consecutive female patients attending a colorectal 2WW clinic at a single trust.ResultsOverall, 56 (57%) of the 98 patients had significant ODS and/or FI (scores >9/20), 33 (34%) had ODS and 40 (41%) had FI. Seventeen patients (17%) had both ODS and FI. Analysis of the 63 patients referred with a change in bowel habit (CIBH) showed 40 (63%) to be Renzi and/or Wexner positive compared with 16 (46%) of the 35 patients who presented without CIBH (p=0.095, Fisher’s exact test). Further analysis showed that 31 (78%) of the 40 patients with FI presented with CIBH compared with 32 (55%) of the 58 without FI (p=0.032). In terms of ODS, 23 (70%) of the 33 patients with ODS presented with CIBH compared with 40 (62%) of the 65 without ODS (p=0.506).ConclusionsOver half of the female patients attending our colorectal 2WW clinic had significant pelvic floor dysfunction (FI/ODS), which may account for their symptoms (especially in the CIBH referral category). While it is important for malignancy to be excluded, many patients may benefit from investigation and management of their pelvic floor dysfunction as the cause for their presenting symptoms.
Abusive Experiences and Young Women's Sexual Health Outcomes: Is Condom Negotiation Self‐Efficacy a Mediator?
Authors: Jones Kelley A. , Cornelius Marie D. , Silverman Jay G. , Tancredi Daniel J. , Decker Michele R. , Haggerty Catherine L. , De Genna Natacha M. , Miller Elizabeth 
Published: April 2016

AbstractCONTEXTIntimate partner violence and reproductive coercion are associated with unintended pregnancies and STDs. Greater condom negotiation self‐efficacy among young women may mediate these associations.METHODSA sample of 841 female adolescents (aged 16–19) and 1,387 young adult women (aged 20–24) recruited from 24 family planning clinics in western Pennsylvania in 2011–2012 reported on intimate partner violence, reproductive coercion, condom negotiation self‐efficacy and sexual health outcomes at baseline and four‐ and 12‐month follow‐ups. Mixed models were used to test associations of intimate partner violence and reproductive coercion with unintended pregnancy and STD diagnosis. The Sobel test of mediation was used to measure indirect effects of condom negotiation self‐efficacy.RESULTSAt baseline, 15% of adolescents and 11% of young adults reported recent intimate partner violence victimization; 7% and 6%, respectively, reported recent reproductive coercion. For both age‐groups, intimate partner violence and reproductive coercion were associated with a reduced level of condom negotiation self‐efficacy (coefficients, −0.27 to −0.13) and increased odds of STD diagnosis (odds ratios, 1.03–1.1). However, only reproductive coercion was associated with unintended pregnancy (odds ratios, 1.1 for each group). The only association that condom negotiation self‐efficacy mediated was between reproductive coercion and unintended pregnancy among young adults (17% of total effect).CONCLUSIONSTargeting condom negotiation self‐efficacy alone in abusive relationships would likely not translate into improved sexual health outcomes in this population. Other strategies are needed to prevent unintended pregnancy and STDs.
Kawaii, kenosis, Verwindung: A reading of kawaii through Vattimo’s philosophy of ‘weak thought’
Authors: Botz-Bornstein Thorsten 
Published: April 2016

Abstract
Kawaii is different from the western cute because it may also include ‘cool’. The paradoxical coexistence of weakness and strength, of cute and cool, is interesting in philosophical terms. Kawaii is not simply weak but equipped with its own kind of strength. In this article, I explore kawaii by using philosophical ideas linked to the paradigm of ‘strength out of weakness’ that appears in the so-called ‘weak thought’ philosophy of Gianni Vattimo. The Heideggerian term Verwindung (twisting) as it is used by Vattimo, is at the centre of this analysis. Vattimo’s philosophy is also based on the Christian idea of kenosis, a classic theological term that can be translated as ‘weakening’. Feminist theologians use the concept of kenosis in order to ‘feminize’ theology. It is in this context that kawaii can be shown as bringing together such antagonistic qualities as submission and subversion. Vattimo’s Verwindung describes the effect of distortion to which gender distinctions are submitted through the impact of kawaii. As a result, kawaii should be seen as femininity without metanarratives because kawaii strips feminist gestures of their metaphysical features.
‘But I am a kid’: Optimizing adolescence in Oshii Mamoru’s The Sky Crawlers
Authors: Nelson Lindsay 
Published: April 2016

Abstract
Oshii Mamoru’s 2008 film The Sky Crawlers imagines a world in which cloned adolescents (Kildren) are made to fight staged aerial battles for the entertainment of the TV-viewing public. This article uses the narrative and visual aesthetic of The Sky Crawlers to examine what it means to be an adolescent, a killer, and a human being in a world where reality and spectacle have become indistinguishable, and where both the bodies of young people and the very idea of adolescence (as a liminal state defined by a lack of experience in and wisdom about the world) have been commodified by corporations. The existence of the Kildren and the world they live in is made all the more vivid through the visual framework of anime, which has a long history of using contrasting drawing styles (hyper-real for machines, handdrawn for humans). This framework allows The Sky Crawlers to re-imagine the idea of ‘deathlessness’ in anime and manga, with the hand-drawn bodies of Kildren characters emphasizing the impermanent, recyclable nature of their existence. The film points to a world in which spectacle reigns supreme, and everything – bodies, emotions, the very concept of adolescence – has the potential to be optimized to enhance that spectacle.
Kyaraben (character bento): The cutesification of Japanese food in and beyond the lunchbox
Authors: Occhi Debra J. 
Published: April 2016

Abstract
The recent boom in cute characters (kyara) has permeated Japanese popular aesthetics to the extent that character-shaped foods have displaced the former emphasis on recreating natural objects in bento (packed lunches) created for preschoolers. Prior to this development, Anne Allison described bento as an ‘ideological state apparatus’. Under this rubric, learning to make a proper bento was a part of training women to be proper mothers of preschoolers, just as eating it quickly and completely helped train the children as model citizens. Contemporary mothers of small children, having been reared on Hello Kitty and her ilk, are now no longer simply the targets of character merchandizing, but the promulgators. Performing the domestic and educational rituals of kyaraben encourages women’s and children’s production and consumption of ‘character culture’.
The two-layer model of ‘kawaii’: A behavioural science framework for understanding kawaii and cuteness
Authors: Nittono Hiroshi 
Published: April 2016

Abstract
‘Kawaii’ is one of the most popular words in contemporary Japan and is recognized as representative of Japanese pop culture. It is often translated into English as ‘cute’, but a subtle difference of nuance seems to exist between the two words. In this article, a framework for research on kawaii from a behavioural science perspective is put forward. After introducing the dictionary definition, history and current usage of kawaii, this article reports survey results of Japanese students and office workers about their attitudes towards kawaii. These findings and past psychological and behavioural science research lead to a two-layer model that consists of kawaii as an emotion and kawaii as a social value. This model postulates that the basis of kawaii is a positive emotion related to the social motivation of watching for and staying with preferable persons and objects, which is typically observed in affection towards babies and infants, but not limited to them. This culturally non-specific, biological trait has been appreciated and fostered in Japan by certain characteristics of Japanese culture. Because previous research on cuteness has been almost exclusively associated with infant physical attractiveness and baby schema, using the relatively fresh, exotic word ‘kawaii’ may be helpful to describe this broader psychological concept.
Using a synchronous online teaching internship to develop pedagogical skills and explore teacher identity: A case study
Authors: Pike Pamela D. 
Published: April 2016

Abstract
Supervised teaching internships can help music students develop procedural knowledge, apply pedagogical content knowledge and acquire teacher identity. It is generally acknowledged that the professional lives of current music majors will encompass a diverse array of activities, including performing, teaching and using technology. However, not all undergraduates appreciate the need to explore teacher identity while developing performance skills. Although technological advances make it possible to teach piano synchronously online, few researchers have investigated the effect of implementing an online teaching internship for undergraduate pianists. This collective case study explored the development of pedagogical techniques and teacher identity among third-year undergraduate pianists during a two-month synchronous online teaching internship. Technology employed included the following: acoustic Disklavier pianos, computers with cameras and microphones, Internet MIDI and the Ethernet. Data were triangulated, and benefits of the online internship included the following: increased pedagogical effectiveness; improved teacher identity; appreciation for current educational technology; increased flexibility; and metacognitive strategies.
Teaching tasks and the composition of a ‘piece’ using music technology in the classroom: Implications for the education and training of teachers
Authors: Minott Mark A. 
Published: April 2016

Abstract
A six-week unit of lessons in music composition using an audio music software (Mixcraft) was used in this action research study as a platform to make transparent the teaching tasks relevant to the use of technology in the music classroom. An examination of music education literature suggests that this is an understudied area, and one of importance to the education and training of teachers generally, and of music teachers specifically. The study utilized 41 grade-9 students in an independent high school for girls in West London, England. Participant observation, teacher lesson plans and a student questionnaire were the data collection methods used. The student questionnaire elicited students’ perception of the tasks performed by the teacher during the unit of lessons and what additional tasks the teacher could have performed to help their composition. Responses to the first question are the primary concern of this study. Responses to the second question were used to aid the teacher’s personal reflection on improving the unit the next time it was implemented. Observations and the teacher’s lesson plans were used to corroborate the findings of the study. The study revealed the dominant and most recurring tasks to be learning support followed by exposition. Technical, preparation and classroom management and computer allocations – although not identified by student participants – were observed to have occurred and hence necessary for the process. Implications for the education and training of teachers generally and of music teachers specifically are outlined.
Book Reviews
Authors: Cuadrado Francisco , Wise Karen , Savage Dr Jonathan 
Published: April 2016

Abstract
Computational Thinking in Sound. Teaching the Art & Science of Music & Technology, Gena R. Greher and Jesse M. Heiness (2014) 1st ed., New York: Oxford University Press, 232 pp., ISBN: 9780199826179, h/bk, $ 99; ISBN: 9780199826193, p/bk, $ 35
Activating Diverse Musical Creativities: Teaching and Learning in Higher Music Education, Pamela Burnard and Elizabeth Haddon (EDS) (2015) London: Bloomsbury, 289 pp., ISBN: 978-1-4725-8911-8, h/bk, £24.99
Music Learning Today: Digital Pedagogy for Creating, Performing and Responding to Music, Bauer, W.I. (2014) 1st edition, New York: Oxford University Press, ISBN: 978-0-19-989059-0, p/bk, £20.99
State school finance inequities and the limits of pursuing teacher equity through departmental regulation
Authors: Baker Bruce D. , Weber Mark 
Published: April 2016

New federal regulations (State Plans to Ensure Equitable Access to Excellent Educators) place increased pressure on states and local public school districts to improve their measurement and reporting of gaps in teacher qualifications across schools and the children they serve. Yet a sole focus on resource disparities between schools within a state ignores an important driver of those disparities: district-level spending variations, particularly when accounting for differences in student populations. The analyses herein evaluate connections between district and school level spending measures and teacher equity measures (such as salary competitiveness and staff: student ratios), and specifically whether inequality in “access to excellent educators” at the school level is greater in states where funding inequalities between school districts are greater. We find that district spending variation explains an important, policy relevant share of school staffing expenditures in 13 states. In many states, including Illinois and New York, a nearly 1:1 relationship exists between district spending variation and school site spending variation. In California, Illinois, Louisiana, New York, Ohio, Pennsylvania and Virginia, district spending is positively associated with competitive salary differentials, average teacher salaries, and numbers of certificated staff per 100 pupils. In each of these states, district poverty rates are negatively associated with competitive salary differentials, average teacher salaries and numbers of certified staff per 100 pupils. As such, regulatory intervention without more substantive changes to state school finance systems, addressing district-level inequities, will likely achieve little. Current federal policy pressures state education agencies to report and attempt to regulate inequities that arise because of school finance systems over which those agencies have no direct influence. Our analysis suggests that the administration would be more likely to meet its goals if it attempted to more directly address state school finance system disparities, placing pressure on state legislatures to equitably and adequately fund schools, and following through with the requirement that state-to-district equity provisions translate into district-to-school equity.
How Much Energy Needs for Running Energy Harvesting Powered Wireless Sensor Node?
Authors: Entezami Fariborz , Zhu Meiling , Politis Christos 
Published: April 2016

Abstract
There is a big challenge for research and industrial engineers to apply energy harvesting powered wireless sensors for practical applications. This is because wireless sensors is very power hungry while current energy harvesting systems can only harvest very limited energy from the ambient environment. In order for wireless sensors to be operated based on the limited energy harvested, understanding of power consumption of wireless sensors is the first task for implementation of energy harvesting powered wireless sensors systems. In this research an energy consumption model has been introduced for wireless sensor nodes and the power consumption in the life cycle of wireless communication sensors, consisting of JN5148 microcontroller and custom built sensors: a 3-axial accelerometer, a temperature sensor and a light sensor, has been studied. All measurements are based on a custom-built test bed. The power required carrying out a life cycle of wireless sensing and transmission is analysed. This paper describes how to analyse the current consumption of the system in active mode and thus power Consumption for sleeping and deployed sensors mode. The results show how much energy needs to run the energy harvesting powered wireless sensor node with JN5148 microcontroller.
The Calculation for Saturated Solubility of Oxygen in Mn–Si Melts Equilibrated with MnO–SiO2 Slags
Authors: Han Pei-Wei , Wang Hai-Juan , Chu Shao-Jun 
Published: April 2016

Abstract
The MnO–SiO2 slag in equilibrium with Mn–Si melts with a Si molar ratio between 0.1 and 0.3 at 1,700 K was a single liquid phase. However, it was liquid phase saturated with solid MnO or solid SiO2 in the case of X
Si less than 0.1 or greater than 0.3, respectively. Based on a subregular solution model, the calculated saturated solubility of oxygen in Mn–Si melts was 0.0236 mass % in pure manganese at 1,700 K and increased with the increasing silicon in the range of X
Si from 0.1 to 0.3. However, the saturated solubility of oxygen decreases as the silicon exceeded 0.3, and the minimum solubility was 0.0041 mass % in pure silicon at 1,700 K. The results could be used to predict the compositions of endogenous oxide inclusions and evaluate the cleanliness of manganese ferroalloy.