bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaginal discharge concentrations of β‐human chorionic gonadotropin, creatinine, and urea for the diagnosis of premature rupture of membranes
Authors: Bouzari Zinatossadat , Shahhosseini Roza , Mohammadnetaj Meadeh , Barat Shahnaz , Yazdani Shahla , Hajian‐Tilaki Karimollah 
Published: December 2017

AbstractObjectiveTo determine the diagnostic value of vaginal discharge concentrations of β human chorionic gonadotropin (β‐hCG), creatinine, and urea to identify premature rupture of membranes (PROM).MethodsAn observational cross‐sectional study was conducted between 12 June, 2014, and 11 June, 2015, among 120 women who were admitted to an Iranian hospital at 28–41 weeks of pregnancy. Women with positive pooling and nitrazine test results were assigned to the PROM group (n=60), whereas those with negative test results were assigned to the control group (n=60). Samples of vaginal discharge were obtained.ResultsMean concentrations of β‐hCG, urea, and creatinine were all higher in the PROM group than in the control group (all P=0.001). The diagnostic accuracies as defined by area under the curve for creatinine, urea, and β‐hCG were 0.891, 0.895, and 0.908, respectively. The corresponding optimal cutoff values were 20.33 μmol/L, 0.94 mmol/L, and 39.5 IU/L, respectively.ConclusionThe vaginal discharge concentrations of all three markers exhibited favorable predictive value for the diagnosis of PROM; however, β‐hCG showed greater diagnostic accuracy than either urea or creatinine.
Cervical cancer screening through human papillomavirus testing in community health campaigns versus health facilities in rural western Kenya
Authors: Huchko Megan J. , Ibrahim Saduma , Blat Cinthia , Cohen Craig R. , Smith Jennifer S. , Hiatt Robert A. , Bukusi Elizabeth 
Published: December 2017

AbstractObjectiveTo determine the effectiveness of community health campaigns (CHCs) as a strategy for human papillomavirus (HPV)‐based cervical cancer screening in rural western Kenya.MethodsBetween January and November 2016, a cluster‐randomized trial was carried out in 12 communities in western Kenya to investigate high‐risk HPV testing offered via self‐collection to women aged 25–65 years in CHCs versus government health facilities. Outcome measures were the total number of women accessing cervical cancer screening and the proportion of HPV‐positive women accessing treatment.ResultsIn total, 4944 women underwent HPV‐based cervical cancer screening in CHCs (n=2898) or health facilities (n=2046). Screening uptake as a proportion of total eligible women in the population was greater in communities assigned to CHCs (60.0% vs 37.0%, P<0.001). Rates of treatment acquisition were low in both arms (CHCs 39.2%; health facilities 31.5%; P=0.408).DiscussionCervical cancer screening using HPV testing of self‐collected samples reached a larger proportion of women when offered through periodic CHCs compared with health facilities. The community‐based model is a promising strategy for cervical cancer prevention. Lessons learned from this trial can be used to identify ways of maximizing the impact of such strategies through greater community participation and improved linkage to treatment.ClinicalTrials.gov registration: NCT02124252.
Transcriptional regulation of CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression pattern in colorectal cancer HCT116 cells
Authors: Kądziołka Beata , Dębski Konrad J. , Bieganowski Paweł , Leśniak Wiesława , Filipek Anna 
Published: December 2017

AbstractThe CacyBP/SIP protein is expressed at a particularly high level in brain, spleen, and various tumors. In this work, we have studied transcriptional regulation of the CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression in colorectal cancer HCT116 cells. We have shown that E2F1, EGR1, and CREB transcription factors bind to the CacyBP/SIP gene promoter and stimulate transcription of CacyBP/SIP gene. The role of CREB was further confirmed by the observation that forskolin, a strong activator of CREB phosphorylation/activity, increased CacyBP/SIP gene promoter activity. Moreover, we have shown that CREB dominant negative mutants, CREB133 and KCREB, inhibits CacyBP/SIP promoter activity. To check the biological significance of increased CacyBP/SIP expression/level we have applied RNA microarray analysis and have found that upregulation of CacyBP/SIP entails changes in mRNA level of many genes involved, among others, in immune processes. © 2017 IUBMB Life, 70(1):50–59, 2018
The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo
Authors: Han Jianlong , Zuo Jinliang , Zhu Dengsong , Gao Chunzheng 
Published: December 2017

BackgroundThe current investigation was aimed to explore the potential associations of SNPs within ADRB2, ADRB1, NPY, and ADRA1A with risk and prognosis of cervical vertigo.MethodsAltogether 216 patients with cervical vertigo and 204 healthy controls were gathered, and their DNAs were extracted utilizing the whole‐blood DNA extraction kit. Besides, the PCR reactions were conducted using the TaqManR single nucleotide polymorphism (SNP) genotyping assays, and the SNPs were detected on the 7900HT real‐time fluorogenic quantitative polymerase chain reaction (PCR) instrument. Finally, the severity of cervical vertigo was classified according to the JOA scoring, and the recovery rate (RR) of cervical vertigo was calculated in light of the formula as: urn:x-wiley:08878013:media:jcla22366:jcla22366-math-0001ResultsThe SNPs within ADRA1A [rs1048101 (T>C) and rs3802241 (C>T)], NPY [rs16476 (A>C), rs16148 (T>C), and rs5574 (C>T)], ADRB1 [rs28365031 (A>G)] and ADRB2 [rs2053044 (A>G)] were all significantly associated with regulated risk of cervical vertigo (all P < .05). Haplotypes of ADRA1A [CT and TC] and NPY [CCT and ATT] were also suggested as the susceptible factors of cervical vertigo in comparison with other haplotypes. Furthermore, the SNPs within ADRA1A [rs1048101 (T>C)], NPY [rs16476 (A>C), rs16148 (T>C)], as well as ADRB1 [rs28365031 (A>G)] all appeared to predict the prognosis of cervical vertigo in a relatively accurate way (all P < .05). Ultimately, the haplotypes of ADRA1A (CC) and NPY (CCT) tended to decrease the RR.ConclusionsThe SNPs within ADRB2, ADRB1, NPY, and ADRA1A might act as the diagnostic biomarkers and treatment targets for cervical vertigo.
Visual body size norms and the under‐detection of overweight and obesity
Authors: Oldham M. , Robinson E. 
Published: December 2017

SummaryObjectivesThe weight status of men with overweight and obesity tends to be visually underestimated, but visual recognition of female overweight and obesity has not been formally examined. The aims of the present studies were to test whether people can accurately recognize both male and female overweight and obesity and to examine a visual norm‐based explanation for why weight status is underestimated.MethodsThe present studies examine whether both male and female overweight and obesity are visually underestimated (Study 1), whether body size norms predict when underestimation of weight status occurs (Study 2) and whether visual exposure to heavier body weights adjusts visual body size norms and results in underestimation of weight status (Study 3).ResultsThe weight status of men and women with overweight and obesity was consistently visually underestimated (Study 1). Body size norms predicted underestimation of weight status (Study 2) and in part explained why visual exposure to heavier body weights caused underestimation of overweight (Study 3).ConclusionsThe under‐detection of overweight and obesity may have been in part caused by exposure to larger body sizes resulting in an upwards shift in the range of body sizes that are perceived as being visually ‘normal’.
Dual‐purpose probe applicable to permittivity measurements and ablation of biological materials
Authors: Seo Taeyoon , Oh Seongwoog , Huh Yeowool , Cho Jeiwon , Kwon Youngwoo 
Published: December 2017

A dual‐purpose probe applicable both to permittivity measurements and ablation of biological materials has been developed. For these purposes, a planar‐type open‐ended coaxial probe was used as an applicator due to its capabilities of broadband permittivity measurements and near‐field ablation. In order to maintain highly efficient power transfer during ablation, an impedance matching network is designed. To verify the dual‐purpose probe, the complex permittivity of several biological materials was measured, and a block of pork muscle was ablated. As a result, permittivity measurements were successfully achieved nearly up to 20 GHz, and the surface temperature of pork muscle was raised up to 70°C with only 31 dBm of incident power at 18 GHz.
Age Differences in Face Processing: The Role of Perceptual Degradation and Holistic Processing
Authors: Boutet Isabelle , Meinhardt-Injac Bozana 
Published: December 2017

Abstract

Objectives
We simultaneously investigated the role of three hypotheses regarding age-related differences in face processing: perceptual degradation, impaired holistic processing, and an interaction between the two.

Methods
Young adults (YA) aged 20–33-year olds, middle-age adults (MA) aged 50–64-year olds, and older adults (OA) aged 65–82-year olds were tested on the context congruency paradigm, which allows measurement of face-specific holistic processing across the life span (Meinhardt-Injac, Persike & Meinhardt, 2014. Acta Psychologica, 151, 155–163). Perceptual degradation was examined by measuring performance with faces that were not filtered (FSF), with faces filtered to preserve low spatial frequencies (LSF), and with faces filtered to preserve high spatial frequencies (HSF).

Results
We found that reducing perceptual signal strength had a greater impact on MA and OA for HSF faces, but not LSF faces. Context congruency effects were significant and of comparable magnitude across ages for FSF, LSF, and HSF faces. By using watches as control objects, we show that these holistic effects reflect face-specific mechanisms in all age groups.

Discussion
Our results support the perceptual degradation hypothesis for faces containing only HSF and suggest that holistic processing is preserved in aging even under conditions of reduced signal strength.
The Relative Drinfeld Commutant of a Fusion Category and α-Induction
Authors: Kawahigashi Yasuyuki 
Published: December 2017

AbstractWe establish a correspondence among simple objects of the relative commutant of a full fusion subcategory in a larger fusion category in the sense of Drinfeld, irreducible half-braidings of objects in the larger fusion category with respect to the fusion subcategory, and minimal central projections in the relative tube algebra. Based on this, we explicitly compute certain relative Drinfeld commutants of fusion categories arising from α-induction for braided subfactors. We present examples arising from chiral conformal field theory.
Efficacy of 8 Different Drug Treatments for Patients With Trigeminal Neuralgia
Authors: Yang Fang , Lin Qiang , Dong Lihua , Gao Xiaohui , Zhang Su’e 
Published: December 2017

Objectives:
Trigeminal neuralgia (TN) is commonly seen in older persons and negatively influences their daily life. Although some research on the efficacy of TN drugs has been conducted, the optimal choice still remains uncertain. Therefore, this network meta-analysis (NMA) evaluated the efficacy and performance of 8 drugs with respect to TN.

Methods:
All literature was retrieved from the PubMed and Embase electronic databases by jointly searching key terms. The only outcome was response rate, expressed as the odds ratio with 95% credible/confidence intervals. Both a pairwise meta-analysis and NMA were conducted. Heat plot and node splitting were computed to measure the consistency between direct and indirect evidence. In addition, surface under cumulative ranking curves were utilized to rank different drugs for treating TN.

Results:
In total, 13 studies and 672 TN patients were included in this NMA. With regard to the primary endpoint response rate, only lidocaine (LDC), botulinum toxin type A (BTX-A), and carbamazepine (CBZ) had a statistical better performance than the placebo. According to the surface under cumulative ranking curves, LDC, BTX-A, and CBZ are the most effective drugs for treating patients with TN.

Conclusions:
Among the 8 drugs investigated, all exhibited a capacity to alleviate TN more than the placebo except for pimozide and proparacaine. Moreover, LDC, BTX-A, and CBZ stood out for their high efficacy and could be recommended as the primary choice of treatment for TN.
DIFFUSE RETINAL VASCULAR LEAKAGE AND CONE–ROD DYSTROPHY IN A FAMILY WITH THE HOMOZYGOUS MISSENSE C.1429G>A (P.GLY477ARG) MUTATION IN CRB1
Authors: Alsulaiman Hamad M. , Schatz Patrik , Nowilaty Sawsan R. , Abdelkader Ehab , Abu Safieh Leen 
Published: December 2017

Purpose:
To describe a specific cone–rod dystrophy phenotype in a family with the homozygous c.1429G>A; p.Gly477Arg mutation in CRB1. The detailed phenotype of subjects with this specific mutation has not been described previously.

Methods:
Clinical examination included full-field electroretinography and high-resolution and widefield retinal imaging and uveitis workup. Molecular genetic analysis included next-generation sequencing of known retinal dystrophy genes and Sanger sequencing for segregation analysis.

Results:
Three affected male siblings (26, 16, and 8 years old) were diagnosed with cone–rod dystrophy, featuring bilateral macular hypoautofluorescent lesions. In addition, the eldest brother was found to have retinal vascular leakage throughout the retina without telangiectasia. Uveitis laboratory workup was unremarkable. The homozygous c.1429G>A; p.Gly477Arg mutation in CRB1 was found to segregate with disease in this family.

Conclusion:
To the best of our knowledge, diffuse vascular leakage without telangiectasia or exudation, with bull's eye maculopathy, has not been reported previously in CRB1-cone rod dystrophy. This expands the phenotype complexity associated with CRB1 mutations and confirms that dystrophies associated with mutations in this gene may appear with features of uveitis.
Benefits of Electromagnetic Navigational Bronchoscopy for Identifying Pulmonary Nodules for Robotic Resections
Authors: Pupovac Stevan S. , Chaudhry Alexander , Singh Vijay A. 
Published: December 2017

Objective The ability to localize pulmonary nodules via the robotic thoracic technique can be challenging at times. This is most evident when nodules are small and/or ground glass in nature. Information regarding methods available to localize these difficult nodules, while maintaining a minimally invasive robotic approach, is limited. Methods We describe a diagnostic and therapeutic method of combining electromagnetic navigational bronchoscopy with a total minimally invasive robotic approach that identifies these difficult-to-localize pulmonary nodules. The technique entails the use of electromagnetic navigational bronchoscopy to place a pleural dye marker with a subsequent pulmonary resection via a robotic thoracic approach. Results A cohort of 15 patients from August 2014 to December 2015 was reviewed. These patients underwent the combined approach of electromagnetic navigational bronchoscopy followed by a robotic pulmonary resection. Fourteen of the 15 patients had a successful combined procedure, which was confirmed with pathology. The range of the nodules was 0.8 to 2 cm. Methylene blue was used for pleural dye marking. On one occasion, the pleural dye was not able to be deciphered. There were no complications from either the electromagnetic navigational bronchoscopy or robotic portions of the procedure. Conclusions Pleural dye marking via electromagnetic navigational bronchoscopy can provide an effective method for localizing pulmonary nodules, while maintaining a minimally invasive robotic approach. This tactic allows one to obtain diagnostic tissue more efficiently, while limiting the potential inability to localize a nodule.
The Effect of Adolescents’ Internet Addiction on Smartphone Addiction
Authors: Ayar Dijle , Bektas Murat , Bektas Ilknur , Akdeniz Kudubes Asli , Selekoglu Ok Yasemin , Sal Altan Sema , Celik Isa 
Published: December 2017

Objective:
The purpose of this study was to evaluate the effect of adolescents’ Internet addiction levels on smartphone addiction.

Methods:
This study included 609 students from three high schools that are located in western Turkey. Numbers, percentages, and averages were used to evaluate the sociodemographic data. The Kolmogorov–Smirnov and Shapiro–Wilk tests were used to determine whether the data had a normal distribution.

Results:
The average age of the participants was 12.3 ± 0.9 years. Of them, 52.3% were male, and 42.8% were 10th graders. All participants had smartphones, and 89.4% of them connected to the Internet continuously with their smartphones. The study found that there was a statistically significant correlation between Internet addiction and smartphone addiction.

Originality and Value:
It was determined that male adolescents with high levels of Internet addiction also had high smartphone addiction levels. On the other hand, sociodemographic variables had no statistically significant effect on smartphone addiction. A number of studies in the relevant literature examined the effects of Internet addiction on adolescents’ smartphone addiction. However, findings of this study are unique because they are specific to the Turkish culture, and there is a limited database in Turkey regarding this issue. The researchers believe that the findings of this study will be beneficial to show the importance of the issue in the international arena and to guide further studies to prevent this addiction because there is no reliable database about smartphone addiction in Turkey.
A Call for Compassionate Care
Authors: Alexander Karen 
Published: December 2017

Abstract
The Substance Abuse and Mental Health Services Administration (2014) reported that 1.1% of pregnant women used nonprescription opiates (either heroin or prescription pills) in the last 30 days. Methadone and buprenorphine are the most common treatments for opiate addiction in pregnant women. Reasons for seeking opiate maintenance treatment (OMT) include keeping custody of one’s children and the hope of developing a healthy parenting relationship. Yet, healthcare organizations and professionals have mixed opinions regarding health promotion within the maternal OMT population. Proper education regarding the growing and complex opiate epidemic continues to remain a void for many healthcare professionals. It is imperative that nurses who regularly interact with women in OMT show compassion and competence. It is important to highlight the universality of the challenges and needs of caring for the OMT population. This Perspectives column will explore and describe the context of maternal nonprescription opiate use and the care mothers in OMT should receive based on established nursing ethical standards.
Symptoms, Nutrition, Pressure Ulcers, and Return to Community Among Older Women With Heart Failure at Skilled Nursing Facilities
Authors: Pressler Susan J. , Jung Miyeon , Titler Marita , Harrison Jordan , Lee Kayoung 
Published: December 2017

Background:
Mortality rate is high for older women with heart failure (HF) who are discharged to skilled nursing facilities (SNFs) after hospitalization, but little is known about their symptoms, nutritional factors, and pressure ulcer status and whether these variables predict the women’s return to the community.

Objectives:
The aims of this study are to characterize symptoms (ie, dyspnea, cognitive dysfunction, depression, and pain) and nutritional and pressure ulcer status, evaluate relationships among symptoms, and examine predictors of return to the community among older women with HF admitted to SNFs.

Methods:
In this pilot observational study, data were collected retrospectively from the electronic medical records and the Minimum Data Set 3.0.

Results:
Data were obtained for 45 women with HF (mean age, 84.8 years). Frequency of symptoms was dyspnea 18%, cognitive dysfunction 20%, depression 5%, and pain 78%. Mean body mass index (BMI) was 29.8 kg/m2. Frequency of pressure ulcer risk was 85% and 18% had pressure ulcers. The 4 symptoms were not significantly related. Younger age (odds ratio, 0.90; P = .023) and BMI of 25 kg/m2 or greater (odds ratio, 5.31; P = .017) predicted return to the community.

Conclusions:
The women in this study had frequent pain, moderately frequent cognitive dysfunction, and high pressure ulcer risk. Surprisingly, few women had dyspnea or depression. Women who were younger with higher BMI were more likely to return to the community. The study needs to be replicated in a larger more diverse group of older patients with HF.
Hinged Lids and Fatal Head Entrapment in Early Childhood
Authors: Byard Roger W. , Cala Allan D. 
Published: December 2017

Abstract
Young children are at risk of head entrapment because they often do not understand potentially dangerous situations or have the intellectual or physical capabilities to self-extricate. Two cases of head entrapment due to hinged lids are presented to demonstrate another rare lethal situation specific to the very young. Case 1 was a 14-month-old boy found suspended by his neck in a semikneeling position under a toilet seat. A horizontal linear bruise measuring 0.6 × 20 mm was present on the right side of the neck with petechial hemorrhages of the forehead. Death was due to neck compression from head entrapment with aspiration of gastric contents. Case 2 was a 17-month-old girl found suspended by her neck from the side of her crib by a hinged cover. A horizontal linear bruise measuring 10 × 50 mm was present immediately below the suprasternal notch with numerous petechial hemorrhages of the conjunctivae and face. Death was due to neck compression from head entrapment. Although these cases are very rare, they do show the potential danger that hinged lids may present to toddlers. Autopsy evaluations require comparisons of injuries with the structure and edges of the entrapping device/object.
Hyperkalemia and Acute Kidney Injury in an Adolescent
Authors: Szadkowski Adam , Pollock Allison J. , Al-Subu Awni M. 
Published: December 2017

Abstract
Addison disease is a rare endocrine disorder, which typically presents with nonspecific symptoms including weight loss, fatigue, and nausea in conjunction with hyponatremia and hyperkalemia. This case demonstrates key diagnostic clues in evaluation of an adolescent who presented with severe hyperkalemia and acute kidney injury that was resistant to insulin, glucose, and sodium polystyrene sulfonate and was found to have primary adrenal insufficiency.