bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the Knee Injury and Osteoarthritis Outcome Score in a Healthy United States Population
Authors: Williamson Tyler , Sikka Robby , Tompkins Marc , Nelson Bradley J. 
Published: December 2015

Background: Patient-reported outcome instruments are frequently used for assessing clinical outcomes after injury and surgery. Previously reported normative data for the Knee injury and Osteoarthritis Outcome Score (KOOS) are limited to a narrow subset of ages and demographics or have not included patients who do not participate in sporting activities. Purpose: To provide normative data for the KOOS in an 18- to 64-year-old population in the United States. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The KOOS was administered to 999 patients or accompanying family members seen in July 2014 at an outpatient orthopaedic clinic in a suburban metropolitan city for an orthopaedic issue unrelated to their knee. Participants were eligible if they self-reported a medical history negative for knee, ankle, or hip surgery and if they did not have a current issue with their knee, ankle, or hip. Means, SDs, medians, ranges, interquartile ranges, and percentiles on the KOOS were calculated by sex, age range, laterality, and history of knee injuries in the past year. Nonparametric statistical analysis and regression analysis were used to evaluate differences in KOOS values between 5 age ranges and between those with a history of knee injuries compared with uninjured participants. Results: There were 402 men and 597 women in the final study cohort. Men scored lower on the Symptoms subscale compared with other subscales (median score: 96.4 for Symptoms, 100.0 for all other subscales) in all age cohorts except the 56- to 64-year age group. Women also reported lower scores in the Symptoms subscale (median score: 96.4 for women aged 18-55 years, 92.9 for women aged 56-64 years). Median scores for the Pain and Knee-related Quality of Life subscales were lower in the 56- to 64-year female cohort (97.2 and 93.8, respectively), compared with the 18- to 55-year female cohort. The Symptoms, Pain, and Knee-related Quality of Life subscales showed the greatest variability for patients of both sexes, particularly in the youngest and oldest cohorts. Three percent of all participants reported a history of knee injuries in the past year, and all KOOS results were significantly lower ( P < .05) in this population compared with uninjured participants. Conclusion: This study provides normative reference values for the KOOS in an 18- to 64-year-old metropolitan United States population. Study findings can aid surgeons in counseling patients and in developing expectations after the treatment of injuries.
Physician Emotional Labour and Job Performance
Authors: Lin Yea-Wen , Chang Wei-Pin 
Published: December 2015

This study explores the relationship between emotional labour and job performance and examines the mediation effects of emotional exhaustion on the relationship between the emotional labour and job performance of physicians. Data were collected from a sample of 530 physicians in Taiwanese hospitals. To achieve these objectives a mediated model was tested using structural equation modelling (SEM) to examine if the hypothesized model fit the data. The hypothesized model fits the data best (χ2 = 173.048, df = 69, p < 0.0001, goodness of fit index GFI = 0.956, comparative fit index (CFI) = 0.968, root-mean-square error of approximation (RMSEA) = 0.053). Path analysis showed that emotional exhaustion plays a fully mediated role on the relationship between deep acting and job performance as well as plays a partially mediated role on the relationship between surface acting and job performance. We confirmed that surface acting for physicians has a direct impact on job performance and affected job performance through the mediating effect of emotional exhaustion. The influences of surface acting on physicians providing medical services are evident. The results deserve the attention of hospital management to better assist physicians to maintain the correct mindset, take appropriate emotional control and patient communication strategies, rather than simply setting rules that require physicians to suppress displays of emotion.
Evaluation of environment and a feline facial pheromone analogue on physiologic and behavioral measures in cats
Authors: Conti Laura MC , Champion Tatiana , Guberman Úrsula C , Mathias Carlos HT , Fernandes Stéfano L , Silva Elisângela GM , Lázaro Monique A , Lopes Aline DCG , Fortunato Viviane R 
Published: December 2015

Objectives This study assessed behavioral and physiologic stress parameters in cats placed in two environments: home and the veterinary hospital. With a widely used scale, several parameters were assessed, including respiratory rate (RR), heart rate (HR), systolic blood pressure (SBP), vagosympathetic responses using calculated intervals (heart rate variability [HRV]10, HRV20 and vasovagal tonus index [VVTI]) and ‘stress attitude’, such as struggling, vocalization and agitation during handling. In addition, we evaluated whether a feline facial pheromone analogue (FFPA) had an effect on any of these measures in either environment. Methods Using a placebo and a pheromone substance, we evaluated 30 adult and healthy cats at home and in veterinary hospitals. Statistical analyses were performed using the Shapiro–Wilk, Kruskal–Wallis, and Dunn or ANOVA and Tukey tests, as well as Spearman’s correlation ( P <0.05). Results We found that exposure to FFPA did not reduce the effects of stress. Some parameters presented differences with regard to environment: the RR was 45 and 70 breaths/min and stress attitude score was 1.3 and 0.0 for cats evaluated at home and at the hospital, respectively. The HR and two vagosympathetic responses were also different between the two environments, with a HR of 160 and 187 beats/min, HRV10 of 14.24 and 14.00, and HRV20 of 14.89 and 14.65 in cats at home and the hospital, respectively. There was no variation in SBP and VVTI parameters between the environments. Conclusions and relevance Exposure to FFPA does not reduce the physiologic and behavioral changes measured in this study. Furthermore, environmental change, physical restraint and manipulation during the physical examination alter RR, HR, HRV and behavior but not SBP and VVTI. This study is relevant because physiologic and behavioral stress can affect the quality and interpretation of physical examination results. This study presents detailed data that show the effects of environment and manipulation on such parameters. Furthermore, this study shows a lack of effect of FFPA on any of these parameters.
Time-Resolved Versus Integrated Transit Planar Dosimetry for Volumetric Modulated Arc Therapy
Authors: Persoon L.C.G.G. , Podesta M. , Nijsten S.M.J.J.G. , Troost E.G.C. , Verhaegen F. 
Published: December 2015

Purpose: It is desirable that dosimetric deviations during radiation treatments are detected. Integrated transit planar dosimetry is commonly used to evaluate external beam treatments such as volumetric-modulated arc therapy. This work focuses on patient geometry changes which result in differences between the planned and the delivered radiation dose. Integrated transit planar dosimetry will average out some deviations. Novel time-resolved transit planar dosimetry compares the delivered dose of volumetric-modulated arc therapy to the planned dose at various time points. Four patient cases are shown where time-resolved transit planar dosimetry detects patient geometry changes during treatment. Methods: A control point to control point comparison between the planned dose and the treatment dose of volumetric-modulated arc therapy beams is calculated using the planning computed tomography and the kV cone-beam computed tomography of the day and evaluated with a time-resolved γ function. Results were computed for 4 patients treated with volumetric-modulated arc therapy, each showing an anatomical change: pleural effusion, rectal gas pockets, and tumor regression. Results: In all cases, the geometrical change was detected by time-resolved transit planar dosimetry, whereas integrated transit planar dosimetry showed minor or no indication of the dose discrepancy. Both tumor regression cases were detected earlier in the treatment with time-resolved planar dosimetry in comparison to integrated transit planar dosimetry. The pleural effusion and the gas pocket were detected exclusively with time-resolved transit planar dosimetry. Conclusions: Clinical cases were presented in this proof-of-principle study in which integrated transit planar dosimetry did not detect dosimetrically relevant deviations to the same extent time-resolved transit planar dosimetry was able to. Time-resolved transit planar dosimetry also provides results that can be presented as a function of arc delivery angle allowing easier interpretation compared to integrated transit planar dosimetry.
The Impact of Nitinol Staples on the Compressive Forces, Contact Area, and Mechanical Properties in Comparison to a Claw Plate and Crossed Screws for the First Tarsometatarsal Arthrodesis
Authors: Aiyer Amiethab , Russell Nicholas A. , Pelletier Matthew H. , Myerson Mark , Walsh William R. 
Published: December 2015

Background. The optimal fixation method for the first tarsometatarsal arthrodesis remains controversial. This study aimed to develop a reproducible first tarsometatarsal testing model to evaluate the biomechanical performance of different reconstruction techniques. Methods. Crossed screws or a claw plate were compared with a single or double shape memory alloy staple configuration in 20 Sawbones models. Constructs were mechanically tested in 4-point bending to 1, 2, and 3 mm of plantar displacement. The joint contact force and area were measured at time zero, and following 1 and 2 mm of bending. Peak load, stiffness, and plantar gapping were determined. Results. Both staple configurations induced a significantly greater contact force and area across the arthrodesis than the crossed screw and claw plate constructs at all measurements. The staple constructs completely recovered their plantar gapping following each test. The claw plate generated the least contact force and area at the joint interface and had significantly greater plantar gapping than all other constructs. The crossed screw constructs were significantly stiffer and had significantly less plantar gapping than the other constructs, but this gapping was not recoverable. Conclusions. Crossed screw fixation provides a rigid arthrodesis with limited compression and contact footprint across the joint. Shape memory alloy staples afford dynamic fixation with sustained compression across the arthrodesis. A rigid polyurethane foam model provides an anatomically relevant comparison for evaluating the interface between different fixation techniques. Clinical Relevance. The dynamic nature of shape memory alloy staples offers the potential to permit early weight bearing and could be a useful adjunctive device to impart compression across an arthrodesis of the first tarsometatarsal joint. Levels of Evidence: Therapeutic, Level V: Bench testing
Variation in Follow-Up Visit Practices Across Clinicians and Conditions
Authors: Liu Caterina Yuan , Gonzales Ralph 
Published: December 2015

Background: Specialty care access is increasingly constrained due to increasing demand for specialty care. Although much attention has been placed on the initial referral decision, much less is known about follow-up visit patterns. We examined the patterns of follow-up visits for new patients to a university-based cardiology practice and identified independent predictors of follow-up visits. Methods: This is a retrospective cohort study of new patient visits using electronic medical record data. The primary outcome was a follow-up visit. Results: Substantial variation in practice patterns by provider persisted after accounting for patient and disease factors. Most follow-up care was concentrated in a small population of patients. Conclusion: Specialty care follow-up visits may represent a significant opportunity for standardization and quality improvement, and further studies are warranted to understand follow-up visits in specialty care. Implications: Better understanding of between-provider differences could identify ways to reduce unnecessary follow-up visits. Level of Evidence: Single-institution study.
Circular RNA enrichment in platelets is a signature of transcriptome degradation
Authors: Alhasan Abd A. , Izuogu Osagie G. , Al-Balool Haya H. , Steyn Jannetta S. , Evans Amanda , Colzani Maria , Ghevaert Cedric , Mountford Joanne C. , Marenah Lamin , Elliott David J. , Santibanez-Koref Mauro , Jackson Michael S. 
Published: December 2015

Key PointsCircular RNAs are hugely enriched in platelets compared with nucleated cell types. Lack of enrichment in megakaryocte progenitors implicates degradation of platelet linear RNAs.
Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia
Authors: Wouters Bas J. , Delwel Ruud 
Published: December 2015

Abstract
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent discoveries have highlighted an additional important role of dysregulated epigenetic mechanisms in the pathogenesis of the disease. In contrast to genetic changes, epigenetic modifications are frequently reversible, which provides opportunities for targeted treatment using specific inhibitors. In this review, we will provide an overview of the current state of epigenetics and epigenetic therapy in AML and will describe perspectives on how to identify promising new approaches for epigenetic targeted treatment.
An update of current treatments for adult acute myeloid leukemia
Authors: Dombret Hervé , Gardin Claude 
Published: December 2015

Abstract
Recent advances in acute myeloid leukemia (AML) biology and its genetic landscape should ultimately lead to more subset-specific AML therapies, ideally tailored to each patient's disease. Although a growing number of distinct AML subsets have been increasingly characterized, patient management has remained disappointingly uniform. If one excludes acute promyelocytic leukemia, current AML management still relies largely on intensive chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT), at least in younger patients who can tolerate such intensive treatments. Nevertheless, progress has been made, notably in terms of standard drug dose intensification and safer allogeneic HSCT procedures, allowing a larger proportion of patients to achieve durable remission. In addition, improved identification of patients at relatively low risk of relapse should limit their undue exposure to the risks of HSCT in first remission. The role of new effective agents, such as purine analogs or gemtuzumab ozogamicin, is still under investigation, whereas promising new targeted agents are under clinical development. In contrast, minimal advances have been made for patients unable to tolerate intensive treatment, mostly representing older patients. The availability of hypomethylating agents likely represents an encouraging first step for this latter population, and it is hoped will allow for more efficient combinations with novel agents.
Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study
Authors: Orwoll Benjamin E. , Spicer Aaron C. , Zinter Matt S. , Alkhouli Mustafa F. , Khemani Robinder G. , Flori Heidi R. , Neuhaus John M. , Calfee Carolyn S. , Matthay Michael A. , Sapru Anil 
Published: December 2015

Abstract
Introduction
The significance of endothelial injury in children with the acute respiratory distress syndrome (ARDS) has not been well studied. Plasma levels of soluble thrombomodulin (sTM), an endothelial surface protein involved in coagulation, have been associated with endothelial injury. We hypothesized that elevated plasma sTM would correlate with mortality and organ failure in children with ARDS.

Methods
We conducted a multicenter prospective observational study of pediatric patients with ARDS between 2008 and 2014. sTM was measured in plasma collected less than 24 hours from ARDS diagnosis. Outcomes were intensive care unit mortality and organ dysfunction by pediatric logistic organ dysfunction scores. Logistic regression was used to adjust for clinically relevant covariates.

Results
Plasma sTM was higher in patients with indirect lung injury compared to direct lung injury (100 ng/mL vs. 86 ng/mL, p = 0.02). Increased sTM levels were correlated with more organ dysfunction in the entire study population (Spearman’s rho = 0.37, p < 0.01). Overall mortality was 16 %. sTM levels were associated with increased mortality in patients with indirect lung injury (OR 2.7 per log(sTM), p = 0.02). These relationships were independent of age, oxygenation defect, or presence of acute kidney injury.

Conclusion
Elevated plasma sTM levels are associated with organ dysfunction in children with ARDS and with higher mortality in children with indirect lung injury. These findings highlight the importance of endothelial injury in children with ARDS and may guide the development of future therapies targeted toward endothelial stabilization, repair, or functional replacement in this population.
Nodal Promotes Functional Luteolysis via Down-Regulation of Progesterone and Prostaglandins E2 and Promotion of PGF2α Synthetic Pathways in Mare Corpus Luteum
Authors: Galvão António , Skarzynski Dariusz , Ferreira-Dias Graça 
Published: December 2015

Abstract
In the present work, we investigated the role of Nodal, an embryonic morphogen from the TGFβ superfamily in corpus luteum (CL) secretory activity using cells isolated from equine CL as a model. Expression pattern of Nodal and its receptors activin receptor A type IIB (ACVR2B), activin receptor-like kinase (Alk)-7, and Alk4, as well as the Nodal physiological role, demonstrate the involvement of this pathway in functional luteolysis. Nodal and its receptors were immune localized in small and large luteal cells and endothelial cells, except ACVR2B, which was not detected in the endothelium. Nodal mRNA in situ hybridization confirmed its transcription in steroidogenic and endothelial cells. Expression analysis of the aforementioned factors evidenced that Nodal and Alk7 proteins peaked at the mid-CL (P &lt; .01), the time of luteolysis initiation, whereas Alk4 and ACVR2B proteins increased from mid- to late CL (P &lt; .05). The Nodal treatment of luteal cells decreased progesterone and prostaglandin (PG) E2 concentrations in culture media (P &lt; .05) as well as mRNA and protein of secretory enzymes steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, cytosolic PGE2 synthase, and microsomal PGE2 synthase-1 (P &lt; .05). Conversely, PGF2α secretion and gene expression of PG-endoperoxidase synthase 2 and PGF2α synthase were increased after Nodal treatment (P &lt; .05). Mid-CL cells cultured with PGF2α had increased Nodal protein expression (P &lt; .05) and phosphorylated mothers against decapentaplegic-3 phosphorylation (P &lt; .05). Finally, the supportive interaction between Nodal and PGF2α on luteolysis was shown to its greatest extent because both factors together more significantly inhibited progesterone (P &lt; .05) and promoted PGF2α (P &lt; .05) synthesis than Nodal or PGF2α alone. Our results neatly pinpoint the sites of action of the Nodal signaling pathway toward functional luteolysis in the mare.
EP24.15 as a Potential Regulator of Kisspeptin Within the Neuroendocrine Hypothalamus
Authors: Woitowich Nicole C. , Philibert Keith D. , Leitermann Randy J. , Wungjiranirun Manida , Urban Janice H. , Glucksman Marc J. 
Published: December 2015

AbstractThe neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase), has been demonstrated to play a key role in the processing and thus the duration of action of the reproductive neuropeptide, GnRH, which signals downstream of Kiss1. Initial in silico modeling implied that Kiss1 could also be a putative substrate for EP24.15. Coincubation of Kiss1 and EP24.15 demonstrated multiple cleavages of the peptide predominantly between Arg29-Gly30 and Ser47-Phe48 (corresponding to Ser5-Phe6 in Kiss-10; Kiss-10 as a substrate had an additional cleavage between Phe6-Gly7) as determined by mass spectrometry. Vmax for the reaction was 2.37±0.09 pmol/min · ng with a Km of 19.68 ± 2.53μM, which is comparable with other known substrates of EP24.15. EP24.15 immunoreactivity, as previously demonstrated, is distributed in cell bodies, nuclei, and processes throughout the hypothalamus. Kiss1 immunoreactivity is localized primarily to cell bodies and fibers within the mediobasal and anteroventral-periventricular hypothalamus. Double-label immunohistochemistry indicated coexpression of EP24.15 and Kiss1, implicating that the regulation of Kiss1 by EP24.15 could occur in vivo. Further studies will be directed at determining the precise temporal sequence of EP24.15 effects on Kiss1 as it relates to the control of reproductive hormone secretion and treatment of fertility issues.
‘Time of My Life?’ The afterlife of Dirty Dancing in the contemporary romantic comedy
Authors: Smith Frances 
Published: December 2015

Abstract
Released in 1987, the continued popularity of Dirty Dancing by Emile Ardolino, and its associated soundtrack cannot be disputed. David Shumway’s analysis of the film’s soundtrack argues that its newly produced songs, such as ‘(I’ve Had) the Time of My Life’ performed by Bill Medley and Jennifer Warnes, rupture the purported realism of the film’s 1963 setting in favour of idealized fantasy. Exploring the implications of Shumway’s claim, this article examines how Dirty Dancing’s theme song has been taken up in two contemporary romantic comedies – Crazy Stupid Love by Glenn Ficarra and John Requa (2011), and Heartbreaker by Pascal Chaumeil (2010) – in which it is used by the male protagonists in order to win favour with their prospective partners. Combining Judith Butler’s work on performativity and citationality with the work of Ian Garwood and Frank Krutnik on the role of quotation in the recent romantic comedy and Rick Altman’s and Richard Dyer’s work on the film musical, the article observes how in both films, the male characters appeal directly to the women’s enjoyment of Dirty Dancing, culminating in scenes where the male and female leads perform a dance to ‘(I’ve had) the Time of My Life’. Complicating the dominant perception of the use of older songs in the contemporary romantic comedy, the article investigates the complex legacy of a hugely popular film whose eclectic soundtrack has seen relatively little academic interest.