bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiome influences efficacy of Endostatin combined with PD-1 blockade against colorectal cancer
Authors: Xu Jie , Tian Yaomei , Zhao Binyan , Hu Die , Wu Siwen , ma Jing , Yang Li 
Published: September 2024

AbstractThe combination of anti-angiogenic drugs and immune checkpoint inhibitors (ICIs) in the treatment of tumors is emerging as a way to improve ICIs-resistant tumor therapy. In addition, gut microbes (GMs) are involved in angiogenesis in the tumor microenvironment and are also associated with the antitumor function of immune checkpoint inhibitors. However, it is unclear whether gut microbes have a role in anti-tumor function in the combination of anti-angiogenic drugs and immune checkpoint inhibitors for cancer treatment. Endostatin, an angiogenesis inhibitor, has been widely used as an antiangiogenic therapy for cancer. We showed that combined therapy with an adenovirus encoding human endostatin, named Ad-E, and PD-1 blockade dramatically abrogated MC38 tumor growth. The structure of intestinal microbes in mice was changed after combination treatment. We found that the antitumor function of combination therapy was inhibited after the elimination of intestinal microbes. In mice with depleted microbiota, oral gavage of Bacteroides fragilis salvaged the antitumor effects of combination Ad-E and αPD-1 monoclonal antibody (mAb) to a certain extent. Further, Bacteroides fragilis could improve CD3+T cells, NK cells, and IFNγ+CD8+ T cells in the tumor microenvironment to inhibit tumor growth. Besides, Bacteroides fragilis might restore antitumor function by down-regulating isobutyric acid (IBA). Our results suggested that GMs may be involved in the combination of Ad-E and αPD-1 mAb for cancer treatment, which has oncological implications for tumor growth dynamics and cancer immune surveillance.
Parametric study of free turbulent slurry jet: influence of particle size and particle concentration on the flow dynamics and thermal behavior of high-speed slurry jet
Authors: Sharma Nilesh Kumar , Dewangan Satish Kumar , Gupta Pankaj Kumar 
Published: September 2024

AbstractA detailed computational investigation was conducted to explore the dynamics of high-speed free slurry jets, with a focus on how variations in abrasive size and concentration affect their behavior. The study yielded several significant observations: Firstly, it was observed that slurry jets containing larger particles exhibited notably higher average velocities, attributed to their inherent self-similar characteristics. Specifically, at the far field of the jet, slurry jets with larger particle sizes demonstrated a 15% increase in velocity compared to those with smaller particles. Additionally, an analysis of turbulent intensity revealed that beyond a certain axial distance (x/D = 10), turbulence levels progressively increased. However, intriguingly, for slurry jets with a high concentration (Co = 15%), there was a notable decrease (28%) in turbulent intensity compared to water jets, indicating a complex interplay between particle size and concentration. Secondly, the study found that as the concentration of particles in the slurry jet increased, there was a corresponding rise in the bulk temperature of the jet. This phenomenon was primarily attributed to the heightened thermal conductivity resulting from the increased density of particles in the water. Furthermore, an examination of the Nusselt number revealed interesting trends. While the Nusselt number exhibited a peak near the nozzle exit, indicative of enhanced heat transfer in this region, it showed a decremental trend along the axial direction of the jet, attributable to jet divergence. In summary, the computational analysis provided valuable insights into the behavior of high-speed slurry jets, highlighting the intricate relationships between abrasive size, concentration, velocity distribution, and thermal characteristics. These findings contribute to a deeper understanding of slurry jet dynamics and have significant implications for various industrial applications.
Whole Lung Irradiation in Rhabdomyosarcoma With Lung Metastases: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group
Authors: Luo Leo Y. , Xue Wei , Qumseya Amira , Vasquez Juan C. , Venkatramani Rajkumar , Wolden Suzanne L. , Casey Dana L. 
Published: September 2024

PURPOSE
Patients with rhabdomyosarcoma with metastatic disease have a poor prognosis despite therapy intensification. The aim of this study was to investigate the efficacy of whole lung irradiation (WLI) in patients with rhabdomyosarcoma and lung metastases.

METHODS
Patients with rhabdomyosarcoma with lung metastases enrolled on four Children's Oncology Group protocols (D9802, D9803, ARST08P1, ARST0431) were retrospectively reviewed. Event-free survival (EFS) and overall survival (OS) were compared between patients who received and did not receive WLI.

RESULTS

In 143 patients with rhabdomyosarcoma with lung metastases, 65 patients (45.5%) received WLI and 78 patients (54.5%) did not receive WLI despite protocol requirements. The 5-year EFS was 38.3% (95% CI, 24.8 to 51.8) in patients who received WLI and 25.2% (95% CI, 13.8 to 36.6) in patients who did not receive WLI (
P
= .0496). The 5-year OS was 45.5% (95% CI, 31.8 to 59.3) in patients who received WLI and 32.4% (95% CI, 20.4 to 44.4) in patients who did not receive WLI (
P
= .08). In exploratory subgroup analyses, the benefit of WLI on EFS and OS was significant in patients 10 years and older. Other clinical factors associated with EFS on univariable analysis included age, histology FOXO1 fusion status, number of metastatic sites, location of metastatic sites, and Oberlin Score.

CONCLUSION
WLI is associated with improved EFS in patients with rhabdomyosarcoma with lung metastases. These results highlight the potential importance of WLI and need for more stringent protocol compliance for administering WLI.
Metabolic Crosstalk in Multimorbidity: Identifying Compensatory Effects Among Diabetes, Hypertension, and Dyslipidemia
Authors: Pitti Erica , Vanni Domitilla , Viceconte Nicola , Lembo Angelo , Tanzilli Gaetano , Raparelli Valeria , Petrella Greta , Cicero Daniel O 
Published: September 2024

Abstract

Context
Metabolomics is becoming increasingly popular for detecting markers that indicate the presence of a specific disease. However, it is usually applied to studying individual ailments, yielding results that may not be directly relevant to people with multiple health conditions.

Objective
Our study proposes a different approach to explore metabolic crosstalk between various disease states.

Design, Setting, and Patients
We conducted a study on subjects at medium to high risk of developing coronary artery disease. We measured the plasma levels of 83 metabolites using nuclear magnetic resonance and analyzed the connections between these metabolites and various risk factors such as diabetes, hypertension, and dyslipidemia. Linear regression and multivariate analysis were combined for this purpose.

Results
Inspection of the metabolic maps created by our analysis helped us efficiently compare profiles. In this way, it was possible to discover opposing metabolic features among single conditions and their combination. Furthermore, we found compensating metabolic effects between diabetes, hypertension, and dyslipidemia involving mainly ketone body metabolism and fatty acid β-oxidation.

Conclusion
Our study introduces a novel approach to investigating how metabolism reacts to the simultaneous presence of multiple health conditions. This has allowed the detection of potential compensatory effects between diabetes, hypertension, and dyslipidemia, highlighting the complexity of metabolic crosstalk in patients with comorbidities. A better understanding of metabolic crosstalk like this could aid in developing focused treatments, resulting in improved therapeutic results.
The use of aesthetic medicine in the treatment of rosacea
Authors: Latała Aleksandra , Wąs Marcin , Zozula Natalia , Tomczewska Zuzanna , Rykucka Aleksandra , Kiełbasa Justyna , Kowalczyk Agata , Bil Katarzyna , Ślesicka Iga , Przestrzelska Magda , Winiarska Natalia 
Published: September 2024

Introduction and purpose:

Rosacea is a chronic inflammatory dermatosis. It mainly affects the central parts of the face and manifests itself with redness, erythema, telangiectasia, and papulopustular lesions. The aim of the work is to review current rosacea therapy techniques, detailing aesthetic medicine treatments.

Material and methods:

In order to create the review, the PubMed and Scopus databases were searched in April and May 2024. The searches took place between April 24 and May 15, 2024 and consisted of a critical analysis of the acquired sources of knowledge.

State of knowledge:

The introduction of lasers to the market has revolutionized the therapy of rosacea and appropriately selected parameters and patient qualification for the treatment ensure therapeutic success. Botulinum toxin is a potent neurotoxin that blocks the release of acetylcholine from the presynaptic vesicle. Appropriate home care is an extremely important factor in maintaining the disease in the remission phase.

Conclusion

Among the possibilities of aesthetic medicine, rosacea therapy is definitely dominated by laser therapy. There are several lasers available on the market today, the most commonly used of which is IPL. Ablative lasers are used to treat a deformed nose caused by rhinophyma. Botulinum toxin is administered as an intradermal injection, thanks to which it reduces erythema and redness of the skin. After appropriate treatment by a dermatologist and aesthetic medicine doctor, well-selected home care plays a key role in maintaining the disease in the remission phase.
Dietetics students' opinion on food and their future profession
Authors: Koritar Priscila , Gaspar Maria Clara de Moraes Prata , Larrea-Killinger Cristina , Alvarenga Marle dos Santos 
Published: September 2024

Introduction: Although it is believed that dietitians will use their opinions about food in their professional practice, few studies evaluated conceptions about food and health among dietitians, and this evaluation could be useful for understanding university education and thinking about possible professional implications. Methods: The study aimed to understand the role of food and what it means to be a dietitian from the perspective of Brazilian dietetics students (495 from 34 institutions in the state of São Paulo) through the questions, "What do you consider the main role of food?" and "For me, being a dietitian means...” The responses were analyzed with the support of AtlasTi software and codified into analytical categories based on content analysis. Results: Of the total, 93% were female and 20% were enrolled in public institutions. Two main categories were defined for food: biological and psycho-sociocultural aspects, and two for nutritionists: health promoter and integral health promoter; 69% indicated the function of food as only biological and 61,3% see the dietitian to be only a health promoter, considering only physiological aspects. Students from public institutions responded more for psycho-sociocultural aspects and integral health promotion (p<0.0001). Conclusion: Most participants present opinions about food in their professional practice focusing mainly on biological and physical health aspects. The possible impact of these opinions on professional practice should be discussed and addressed so that undergraduation can expand critical training and better professional practice.
Validated UV-C bidirectional reflectance distribution function measurements with a spectrophotometer directional reflectance module
Authors: Goldfain Aaron M. , Waters Grace E. , Davis Lynn , Patrick Heather J. , Germer Thomas A. 
Published: September 2024

The efficacy and safety of UV disinfection systems depend on the
radiant flux throughout the space being disinfected, which in turn
depends on the directional reflectance of materials located within the
space. Little publicly available data exists on the directional
reflectance of common materials in the germicidal UV spectral range,
220–280 nm. We present methods to validate directional
reflectance (bidirectional reflectance distribution function)
measurements performed with a spectrophotometer and provide
measurement results for materials commonly found in public spaces. The
data presented may lead to improved models of UV disinfection efficacy
and safety, and the methods described will enable other researchers to
readily collect traceable UV directional reflectance data.
Development of new real-time PCR assays for detection and species differentiation of Plasmodium ovale
Authors: He Wenqiao , Sendor Rachel , Potlapalli Varun R. , Kashamuka Melchior M. , Tshefu Antoinette K. , Phanzu Fernandine , Kalonji Albert , Ngasala Billy , Thwai Kyaw Lay , Juliano Jonathan J. , Lin Jessica T. , Parr Jonathan B. 
Published: September 2024

Background
The parasite species Plasmodium ovalecurtisi (P. ovalecurtisi) and Plasmodium ovalewallikeri (P. ovalewallikeri), formerly known as Plasmodium ovale, are endemic across multiple African countries. These species are thought to differ in clinical symptomatology and latency, but only a small number of existing diagnostic assays can detect and distinguish them. In this study, we sought to develop new assays for the detection and differentiation of P. ovalecurtisi and P. ovalewallikeri by leveraging recently published whole-genome sequences for both species.

Methods
Repetitive sequence motifs were identified in available P. ovalecurtisi and P. ovalewallikeri genomes and used for assay development and validation. We evaluated the analytical sensitivity of the best-performing singleplex and duplex assays using synthetic plasmids. We then evaluated the specificity of the duplex assay using a panel of samples from Tanzania and the Democratic Republic of the Congo (DRC), and validated its performance using 55 P. ovale samples and 40 non-ovale Plasmodium samples from the DRC.

Results
The best-performing P. ovalecurtisi and P. ovalewallikeri targets had 9 and 8 copies within the reference genomes, respectively. The P. ovalecurtisi assay had high sensitivity with a 95% confidence lower limit of detection (LOD) of 3.6 parasite genome equivalents/μl, while the P. ovalewallikeri assay had a 95% confidence LOD of 25.9 parasite genome equivalents/μl. A duplex assay targeting both species had 100% specificity and 95% confidence LOD of 4.2 and 41.2 parasite genome equivalents/μl for P. ovalecurtisi and P. ovalewallikeri, respectively.

Conclusions
We identified promising multi-copy targets for molecular detection and differentiation of P. ovalecurtisi and P. ovalewallikeri and used them to develop real-time PCR assays. The best performing P. ovalecurtisi assay performed well in singleplex and duplex formats, while the P. ovalewallikeri assay did not reliably detect low-density infections in either format. These assays have potential use for high-throughput identification of P. ovalecurtisi, or for identification of higher density P. ovalecurtisi or P. ovalewallikeri infections that are amenable to downstream next-generation sequencing.
Gastrointestinal Vasculitis in Adult Patient With Dermatomyositis Presenting as Hematemesis
Authors: Min Susie , Yen Debra W. , Bongiovanni Gail L. 
Published: September 2024

ABSTRACT
Dermatomyositis (DM) is an inflammatory disease of the muscles and skin. Severe gastrointestinal (GI) involvement, characterized by GI bleeding and perforation secondary to underlying vasculopathy, is rarely seen. We describe a case of newly diagnosed DM in a 75-year-old woman who presented with a rash and muscle weakness. She then had sudden onset of hematemesis and was found to have duodenal ulcers due to leukocytoclastic vasculitis from her DM. Our aim was to highlight the need for recognition of GI involvement in adults with DM.
Pengaruh Pembangunan Jalan Tol terhadap Perubahan Tata Guna Lahan dan Luas Lahan Sawah di Kabupaten Brebes
Authors: Suryaningsih Widiani , Siregar Hermanto , Mulatsih Sri 
Published: September 2024

Kabupaten Brebes merupakan salah satu wilayah yang terkena dampak pembangunan Tol Trans Jawa. Pembangunan infrastruktur jalan (jalan tol) mendorong terjadinya perubahan tata guna lahan dari satu peruntukan ke peruntukan lainnya. Diantara perubahan tersebut adalah adanya penyempitan lahan sawah karena terkonversi menjadi peruntukan lainnya. Tujuan penelitian ini adalah untuk menganalisis perubahan tata guna lahan dan luas lahan sawah di kabupaten Brebes sebagai pengaruh pembangunan jalan tol pada tiga titik tahun yaitu tahun 2011, 2016, dan 2019. Penelitian ini menggunakan Analisis Spasial (Overlay) ArcGIS 10.4, menggunakan data peta land use 2011 dari BPN, peta land use 2016 dari Dinas Pengelolaan Sumber Daya Air dan Penataan Ruang Kabupaten Brebes, dan peta land use 2019 hasil digitasi menggunakan Google Earth dan Sentinel. Hasil penelitian menunjukkan terjadinya perubahan tata guna lahan termasuk didalamnya terjadi konversi lahan sawah ke peruntukkan lainnya. Perubahan tata guna lahan pada rentang tahun 2011-2019 didominasi dengan pengurangan luas lahan sawah dan hutan. Luas lahan sawah di kabupaten Brebes pada tahun 2011 adalah 79.245,41 ha, sedangkan pada tahun 2016 menjadi 68.312,28 ha, atau mengalami konversi seluas 10.933,12 ha (13,80%) dan pada tahun 2019 menjadi 63.496,65 ha atau mengalami konversi seluas 4.815,64 ha (7,05%). Di sisi lain terjadi pula penambahan luas kawasan permukiman dan tegalan/ladang. Luas permukiman pada tahun 2011 yaitu 12.321,58 ha, pada 2016 menjadi 21.487,62 ha atau bertambah seluas 9.166,04 ha (74,39%), dan pada tahun 2019 menjadi 24.062,54 ha atau bertambah seluas 2.574,92 ha(28,09%). Luas tegalan pada 2011 yaitu 1.556,28 ha, pada 2016 menjadi 6.923,,42 ha atau bertambah seluas 5.367,14 ha (344,87%) dan pada tahun 2019 menjadi 10.977,37 ha atau bertambah seluas 4.053,95 ha (75,53%).
A Bibliography of Publications in Economic and Social History printed in Poland in 1977
Authors: Kowal Ewelina , Kowal Stefan 
Published: September 2024

A Bibliography of Publications in Economic and Social History in Poland in 1977
I. Bibliography 309II. Methodology, thoory and history of oconomic thought 309 III. Sources and source studies 310 IV. General publications 311 V. Demography 314 VI. Social structure and mobility 317 VII. Labour, social movements and trade union 320 VIII. Social and economic relations in rural communities 322 IX. Towns and urbanization processes 324 X. Industry, mining, handicraft and architecture 327 XI. Transport and communication 331 XII. Maritime economy, aquatic economy 331 XIII. Trade 331 XIV. Credit, finance, money and prices 332 XV. Insurance and social welfare 334 XVI. Consumption 336
Self-learning and autonomously adapting manufacturing equipment for the circular factory
Authors: Fleischer Jürgen , Zanger Frederik , Schulze Volker , Neumann Gerhard , Stricker Nicole , Furmans Kai , Pfrommer Julius , Lanza Gisela , Hansjosten Malte , Fischmann Patrick , Dvorak Julia , Klein Jan-Felix , Rauscher Felix , Ebner Andreas , May Marvin Carl , Gönnheimer Philipp 
Published: September 2024

Abstract
The integration of both linear and circular processes in one production system poses significant challenges. In particular, the reprocessing of end-of-life products is associated with uncertainties at all levels of the production system, from the initial planning and control through to the executing production hardware and intralogistics. To address these challenges, this article presents approaches for self-learning and autonomously adapting production equipment for the Circular Factory. Initially, hardware and software solutions are developed to cover the necessary processes. Reprocessing is covered by modular and reconfigurable manufacturing cells, which also include new process chains such as the combination of additive-subtractive processes. The provided capabilities must be applied to ever new products, for example by transferring human procedures for unknown products to the production equipment. Lastly, an overall robust and dynamic production planning and control system is developed that maintains continuous operation even in unforeseen situations. The resulting highly dynamic overall system is connected by an autonomous intralogistics system.
Morse index bound of simple closed geodesics on 2-spheres and strong Morse inequalities
Authors: Ko Dongyeong 
Published: September 2024

Abstract
We give a Morse-theoretic characterization of simple closed geodesics on Riemannian 2-spheres.
On any Riemannian 2-sphere endowed with a generic metric, we show there exists a simple closed geodesic with Morse index 1, 2 and 3.
In particular, for an orientable Riemannian surface, we prove strong Morse inequalities for the length functional applied to the space of simple closed curves.
Enhancing the machining productivity in PMEDM for titanium alloy with low-frequency vibrations associated with the workpiece
Authors: Le Quang Dung , Huu Phan Nguyen , Van Dua Tran , Van Thien Nguyen , Thangaraj Muthuramalingam 
Published: September 2024

Abstract
The incorporation of frequency vibration into the powder mixed electric discharge machining (PMEDM) process has the potential to significantly enhance the productivity and quality of the machining process, as well as to provide a great deal of opportunities in this sector. An analysis and evaluation of the machining productivity (material removal rate [MRR]) in PMEDM with low-frequency vibration was carried out in this work by considering SKD61 as a workpiece. The oil dielectric solution mixed with titanium powder was used as a dielectric medium with red copper (Cu) as the electrode. At this point in time, the process technology parameters that have been chosen for inquiry are as follows: current (I), pulse on time (T
on), powder concentration (C
p), P, F, and A. The Taguchi technique (L25) was used to create the experimental matrix. With the use of analysis of variance, it was able to examine the impact that the factors had on MRR, and the analysis was utilized to ascertain the highest possible value of MRR. I was the parameter that has the most significant effect, according to the findings, whereas T
on was the parameter that has the least significant effect. The maximum value of the MRRmax is equal to 31.29 mm3/min.