bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYSTEMATICS OF THE GENERA OF THE ORDER ASCOGLOSSA (GASTROPODA)
Authors: MARCUS EVELINE d. B.-R. 
Published: February 2017

Abstract
List of the genera of Ascoglossa with their distinctive characters. The type species of Cylindrobulla, C. beaui Fischer, 1856, is maintained in the Cephalaspidea Diaphanacea, together with two further species, as subfamily Cylindrobullinae, by reason of their radula. The genus Ascobulla Marcus, 1972, remains in the Ascoglossa, suborder Volvatellacea, family Volvatellidae. The Acochlidiacea Ganitus Marcus, 1953, and Paraganitus Challis, 1968, have ascoglossan teeth. They have no ascus and shed the worn teeth. Their nerve ring lies in front of the pharynx. Therefore they are retained in the Acochlidiacea.
Two new genera are introduced: Roburnella, type species Lobiger wilsoni Tate, 1889, and Pattyclaya, type species Elysia arena Carlson & Hoff, 1977; and two new species: Elysia pagenstecheri for Actaeon viridis Pagenstecher, 1863, and Placida babai for Placida dendritica Baba, 1955, from Japan, whose tooth is different from the European dendritica (Alder & Hancock, 1843). The genus type of Costasiella, C. virescens Pruvot-Fol, 1951, is described in detail, and the species belonging to the genus are compared.
The characters considered as generic in the diagnoses of Stiliger and Ercolania occur in such varied combinations, that a generic separation is not feasible. Hence, I synonymize Ercolania to Stiliger. Bosellia differs from the elysiids in wanting parapodia and in number of chromosomes. I assign it to the family Boselliidae.
Platyhedyle denudata Salvani-Plawen, 1973, with its suborder Platyhedylacea Rankin, 1979, is transferred from the Acochlidiacea to the Ascoglossa.
Biological Weighting Function for RBE Specification of Neutron Therapy Beams. Intercomparison of 9 European Centres
Authors: Pihet P. , Menzel H.G. , Schmidt R. , Beauduin M. , Wambersie A. 
Published: February 2017

Abstract
Microdosimetric measurements (0.5 inch TEPC, 2 µm simulated diameter) were performed in similar conditions for 14 neutron beams with energies ranging from p(4)+Be to p(65)+Be used for radiobiology and therapy. They were collected in an intercomparison programme currently carried out by the EORTC at European facilities and aimed at the comparison of the radiation quality (in terms of RBE) of a given neutron beam with a reference neutron beam. Indeed, accurate physical and biological characteristics for these beams are urgently required. The large RBE differences (up to 50%) observed between different Neutron Therapy Centres must be accurately (&lt;±5%) taken into account for the comparison of clinical results. In order to provide a practicable solution to the existing and unsolved problem of accounting for radiation quality variations in neutron therapy, RBE against lineal energy weighting functions have been established by unfolding methods using radiobiological data and microdosimetric spectra obtained under identical conditions at the neutron beams investigated. This empirical procedure enabled the determination of the best accuracy achievable in predicting RBE variations between neutron beams using their weighted mean lineal energy.
The examination of power and politics in a conservation organisation
Authors: Powell Lisa , Tilt Carol 
Published: February 2017

Purpose
For more than three decades, researchers have been searching for evidence of corporate economic, social and environmental sustainability, the holy grail of corporate success in a socially and environmentally conscious world of the future. The vast majority of entities that researchers have investigated have focussed on the primary goal of profit maximisation, with only vaguely articulated (if any) social and environmental targets. Very little research has been undertaken to expose the inner workings of organisations that are striving primarily to improve environmental outcomes within a commercial setting. The purpose of this paper is to expose the inside details of an organisation that tried but failed, and highlights the role of power and politics in its demise.

Design/methodology/approach
The “processual” or “contextualist” (Burns, 2000, p. 568) methodology adopted in this investigation has facilitated the interpretation and understanding of complex inter-relationships existing amongst key management personnel. The method steps undertaken included observation and documentation of organisational strategic and operational decision-making practices over a period of 22 months and the examination and analysis of over 800 documents prepared either by or about the organisation.

Findings
Examining the inter-relationships of power and politics amongst key players during a period of significant change revealed an intense struggle for corporate survival between two management groups: the original “environmentalist” managers who prepared the entity for listing on the Australian Securities Exchange (ASX); and, the introduced “economic rationalist” managers who guided it through the post listing phase. A failure to effectively transition the power held over resources, decision-making and meanings from the old to the new managers proved to significantly challenge the organisation and possibly contributed to its ultimate demise. Some important lessons were highlighted, particularly the need to develop and establish shared understandings. It is suggested that for a business to move closer to being sustainable, rather than allowing one of the existing paradigms to dominate, a new business model needs to emerge.

Originality/value
The practical implementation of conservation activities on a large commercial scale is a controversial notion. The investigation of this unique case through a period of significant change represents an important experiment in the quest for sustainability and reveals valuable lessons that may guide other organisations that follow in its wake.
Key performance indicators for excellent teachers in Malaysia
Authors: Amzat Ismail Hussein 
Published: February 2017

Purpose
The purpose of this paper is to create a key performance indicator (KPI) that can be used as the benchmark tool for teaching performance and practices of both excellent teachers (ETs) and non-ETs and to investigate the possible interrelationships between the five thinking domains (teachers’ teaching philosophy, teaching objective, pedagogical content knowledge, teachers’ expectations and management style).

Design/methodology/approach
This study uses a quantitative approach with a sample of 306 ETs from eight states including the Federal Territory. Exploratory factor analysis was used to validate the instrument and confirmatory factor analysis for model fit.

Findings
The findings showed that an excellent classroom management style was the most significant domain for KPI with the highest factor loading, followed by ETs’ teaching philosophy and objectives. It revealed that there was no significant relationship between ETs’ expectations and their classroom management style and that the relationships between the other domains were weak.

Originality/value
With this research creating a KPI model for excellent teaching practices, it is suggested that an in-depth review should be conducted concerning the standardization of the classroom management and the national teaching objectives in Malaysia. Perhaps representatives from the Ministry of Education and the school principals could go into the field to determine whether the excellent and non-ETs are fulfilling the national education objectives and meeting the expectations. This could lead to setting KPIs for achieving teaching objectives among the ETs.
Rational and emotional factors of customer satisfaction and brand loyalty in a business-to-business setting
Authors: Elsäßer Marc , Wirtz Bernd W. 
Published: February 2017

Purpose
Reaching customer satisfaction and brand loyalty in a business-to-business setting is still an area of rising interest to both researchers and practitioners. Compared to consumer branding, there is notably very little known about the success factors of industrial branding and how to convince buyers rationally and emotionally in business-to-business markets. Therefore, this paper aims to examine the success factors of branding in a business-to-business setting and analyze their performance impact on customer satisfaction and brand loyalty.

Design/methodology/approach
In total, 258 buyers of mechanical and plant engineering companies participated in an online survey. Data analysis was performed by using confirmatory factor analysis and structural equation modeling.

Findings
The results reveal that rational brand quality consists of the three dimensions, product quality, service quality and distribution quality, whereas consistent advertising style, brand image, country-of-manufacture image and salesperson’s personality are dimensions of emotional brand associations. All dimensions positively influence customer satisfaction and brand loyalty.

Originality/value
This study offers a certain value compared to the relevant literature mentioned in literature review. Compared to a large majority of the papers, the integration of rational and emotional factors in an integrative and complex model implies novelty. For example, Davis et al. (2008) and Baumgarth and Binckebanck (2011) focus on specific exogenous factors in their studies, namely, brand awareness and brand image, respectively, sales force impact combined with product quality and non-personal communication. In contrast, Van Riel, Pahud de Mortanges and Streukens (2005), Chen et al. (2011) and Chen and Su (2012) conceptualized a more complex model but did not separate rational and emotional factors. Jensen and Klastrup (2008) were the only authors who made this separation, but they did not include well-known emotional success factors such as brand image or country-of-manufacture image in their research model. Furthermore, an endogenous causal chain representing an observable consumer behavior is missing. This paper fills this gap.
Market responsiveness: antecedents and the moderating role of external supply chain integration
Authors: Luu Tuan 
Published: February 2017

PurposeThe interaction between opening and closing behaviors of ambidextrous leadership produces “change” force throughout the organization in proactive response to market forces. This research aims to assess the role of ambidextrous leadership in fostering entrepreneurial orientation (EO) and market responsiveness. The research also seeks an insight into how external supply chain integration moderates the positive effect of EO on market responsiveness.Design/methodology/approachResearch data were collected from 327 meso-level managers and 517 subordinates from chemical manufacturing companies in the Vietnam business context.FindingsResearch findings shed light on the positive effect of ambidextrous leadership on EO, which in turn contributes to market responsiveness. The moderation role that external supply chain integration plays on the EO–market responsiveness linkage was also grounded on the data set.Originality/valueThrough the identification of the predictive roles of ambidextrous leadership and EO for market responsiveness, the current research indicates the convergence between leadership, EO and market responsiveness research streams.
Reflections on CSR: the case of Egypt
Authors: Darrag Menatallah , Crowther David 
Published: February 2017

PurposeThe purpose of this paper is to review the corporate social responsibility (CSR) concept in Egypt via six sub-purposes which are the operational definition, activities, corporations’ strategic direction, budgeting and drivers for and obstacles against CSR alongside the implications of the January 25th 2011’s revolution on the concept.Design/methodology/approachThis research is a perception study adopting a mixed methodology. A sample of 20 corporate managers undertaking CSR activities had been interviewed. Results are analyzed using content analysis and non-parametricz-tests.FindingsThe research identified the prevalent hands-on definitions of CSR which highlight an identification problem, as well as the leading two activities undertaken that are highly linked to the lack of a corporate strategic direction. Also, it showed that budgeting was a vague undisclosed aspect and further highlighted the drivers for and obstacles against CSR before and in transition post January 25th 2011, revolution.Practical implicationsThis overview serves as a building block for practitioners to identify the CSR build-up in Egypt, to guide further current or future endeavors undertaken.Originality/valueThis paper provides a genuine contextualized review of CSR in Egypt that had been a reported gap in literature by identifying its operational definition, activities, budgeting, corporations’ strategic direction and drivers for and obstacles against the concept in light of the timeline pre and in-transition post the January 25th 2011 revolution.
Population pharmacokinetics and site of action exposures of veliparib with topotecan plus carboplatin in patients with haematological malignancies
Authors: Mehrotra Shailly , Gopalakrishnan Mathangi , Gobburu Jogarao , Greer Jacqueline M. , Piekarz Richard , Karp Judith E. , Pratz Keith , Rudek Michelle A. 
Published: February 2017

AimsVeliparib is a potent inhibitor of poly(ADP‐ribose) polymerase (PARP) enzyme. The objectives of the analysis were to evaluate the effect of baseline covariates and co‐administration of topotecan plus carboplatin (T + C) on pharmacokinetics of veliparib in patients with refractory acute leukaemia, and compare veliparib concentration in various biological matrices.MethodsA population pharmacokinetic model was developed and effect of age, body size indices, sex, creatinine clearance (CrCL) and co‐administration of T + C on the pharmacokinetics of veliparib were evaluated. The final model was qualified using bootstrap and quantitative predictive check. Linear regression was conducted to correlate concentrations of veliparib in various biological matrices.ResultsA two compartment model with first‐order absorption with Tlag described veliparib pharmacokinetics. The apparent clearance (CL/F) and volume (Vc/F) were 16.5 l h−1 and 122.7 l, respectively. The concomitant administration of T + C was not found to affect veliparib CL/F. CrCL and lean body mass (LBM) were significant covariates on CL/F and Vc/F, respectively. While a strong positive relationship was observed between veliparib concentrations in plasma and bone marrow supernatant, no correlation was observed between plasma and peripheral blood or bone marrow blasts.ConclusionsConsistent with veliparib's physiochemical properties and its elimination mechanism, LBM and CrCL were found to affect pharmacokinetics of veliparib while concomitant administration of T + C did not affect veliparib's CL/F. Plasma concentrations were found to be a reasonable surrogate for veliparib concentrations in peripheral blood and bone marrow supernatant but not blasts. The current model will be utilized to conduct exposure‐response analysis to support dosing recommendations.
What Do We See When We See Total Darkness?
Authors: Ordóñez Angulo Emmanuel 
Published: February 2017

AbstractSeeing total darkness is a peculiar perceptual state: in it, the subject is visually aware of something while seeming to fail to be aware of anything. Recent treatments of the topic (Sorensen , Soteriou ) leave this particular puzzle unsolved. Here, I attempt a solution. Following Dretske, I begin by suggesting that the perceptual report ‘S sees (total) darkness’ is ambiguous between two distinct kinds of perceptual states: epistemic and non‐epistemic. This will lead to an examination of the metaphysics of what is supposed to be seen. I show, on the one hand, the difficulty of reducing the perception of total darkness to the perception of a particular instantiation of a property, and on the other, that it has important similarities with the perception of (non‐particular) ‘stuff’. I propose, finally, that the solution to the puzzle might involve postulating a novel ontological status for total darkness: that of a ‘concrete universal’. Potential implications of interest for particularism and for naïve realism are suggested.
The geobiological nitrogen cycle: From microbes to the mantle
Authors: Zerkle A. L. , Mikhail S. 
Published: February 2017

AbstractNitrogen forms an integral part of the main building blocks of life, including DNA, RNA, and proteins. N2 is the dominant gas in Earth's atmosphere, and nitrogen is stored in all of Earth's geological reservoirs, including the crust, the mantle, and the core. As such, nitrogen geochemistry is fundamental to the evolution of planet Earth and the life it supports. Despite the importance of nitrogen in the Earth system, large gaps remain in our knowledge of how the surface and deep nitrogen cycles have evolved over geologic time. Here, we discuss the current understanding (or lack thereof) for how the unique interaction of biological innovation, geodynamics, and mantle petrology has acted to regulate Earth's nitrogen cycle over geologic timescales. In particular, we explore how temporal variations in the external (biosphere and atmosphere) and internal (crust and mantle) nitrogen cycles could have regulated atmospheric pN2. We consider three potential scenarios for the evolution of the geobiological nitrogen cycle over Earth's history: two in which atmospheric pN2 has changed unidirectionally (increased or decreased) over geologic time and one in which pN2 could have taken a dramatic deflection following the Great Oxidation Event. It is impossible to discriminate between these scenarios with the currently available models and datasets. However, we are optimistic that this problem can be solved, following a sustained, open‐minded, and multidisciplinary effort between surface and deep Earth communities.
Impaired Mental Health‐Related Quality of Life in Patients with Idiopathic Ventricular Fibrillation
Authors: VISSER MARLOES , PEREIRA LEONOR COOLS PAULINO , MASTENBROEK MIRJAM H. , VERSTEEG HENNEKE , HASSINK RUTGER J. 
Published: February 2017

BackgroundIdiopathic ventricular fibrillation (iVF) is diagnosed in cardiac arrest survivors without an identifiable cause. Data regarding the health‐related quality of life (HRQoL) in iVF patients are lacking. The purpose of this study was to investigate the HRQoL of iVF patients and to compare it to patients with an implantable cardioverter defibrillator (ICD) diagnosed with an underlying disease and healthy subjects.MethodsIn 61 iVF patients with an ICD (iVF‐ICD) and 59 ICD patients with a diagnosis (diagnosis‐ICD), HRQoL was assessed using the 12‐item Short‐Form Health Survey (SF‐12), the EuroQoL‐5 dimensions (EQ‐5D), the 9‐item Patient Health Questionnaire, and the ICD Patient Concerns (ICDC) Questionnaire. In addition, 860 healthy subjects completed the SF‐12.ResultsIVF‐ICD showed similar SF‐12 physical summary scores compared with diagnosis‐ICD patients (50.8 [interquartile range (IQR) = 42.1–53.9] vs 54.1 [IQR = 46.5–58.3]; P = 0.080) and healthy subjects (51.8 [IQR = 45.9–54.1]; P = 0.691). The mental summary score was impaired in iVF‐ICD patients compared with diagnosis‐ICD patients (45.9 [IQR = 40.7–49.4] vs 54.6 [IQR = 46.0–57.9]; P < 0.001) and healthy subjects (47.7 [IQR = 43.0–50.4]; P = 0.027). Scores on all five EQ‐5D domains were similar between iVF‐ICD patients and diagnosis‐ICD patients, as well as symptoms of severe depression (19% vs 12%; P = 0.101). ICD concerns were similar between iVF‐ICD and diagnosis‐ICD patients (ICDC‐scores 2 vs 2; P = 0.494).ConclusionsData suggest that there is a reduced mental HRQoL in patients with iVF compared to other cardiac arrest survivors. Screening and treatment of psychological distress should therefore be considered in iVF patients.
Establishment of a tobacco BY2 cell line devoid of plant‐specific xylose and fucose as a platform for the production of biotherapeutic proteins
Authors: Hanania Uri , Ariel Tami , Tekoah Yoram , Fux Liat , Sheva Maor , Gubbay Yehuda , Weiss Mara , Oz Dina , Azulay Yaniv , Turbovski Albina , Forster Yehava , Shaaltiel Yoseph 
Published: February 2017

SummaryPlant‐produced glycoproteins contain N‐linked glycans with plant‐specific residues of β(1,2)‐xylose and core α(1,3)‐fucose, which do not exist in mammalian‐derived proteins. Although our experience with two enzymes that are used for enzyme replacement therapy does not indicate that the plant sugar residues have deleterious effects, we made a conscious decision to eliminate these moieties from plant‐expressed proteins. We knocked out the β(1,2)‐xylosyltranferase (XylT) and the α(1,3)‐fucosyltransferase (FucT) genes, using CRISPR/Cas9 genome editing, in Nicotiana tabacum L. cv Bright Yellow 2 (BY2) cell suspension. In total, we knocked out 14 loci. The knocked‐out lines were stable, viable and exhibited a typical BY2 growing rate. Glycan analysis of the endogenous proteins of these lines exhibited N‐linked glycans lacking β(1,2)‐xylose and/or α(1,3)‐fucose. The knocked‐out lines were further transformed successfully with recombinant DNaseI. The expression level and the activity of the recombinant protein were similar to that of the protein produced in the wild‐type BY2 cells. The recombinant DNaseI was shown to be totally free from any xylose and/or fucose residues. The glyco‐engineered BY2 lines provide a valuable platform for producing potent biopharmaceutical products. Furthermore, these results demonstrate the power of the CRISPR/Cas9 technology for multiplex gene editing in BY2 cells.
Mutants in the imprinted PICKLE RELATED 2 gene suppress seed abortion of fertilization independent seed class mutants and paternal excess interploidy crosses in Arabidopsis
Authors: Huang Fang , Zhu Qian‐hao , Zhu Anyu , Wu Xiaoba , Xie Liqiong , Wu Xianjun , Helliwell Chris , Chaudhury Abed , Finnegan E. Jean , Luo Ming 
Published: February 2017

SummaryEndosperm cellularization is essential for embryo development and viable seed formation. Loss of function of the FERTILIZATION INDEPENDENT SEED (FIS) class Polycomb genes, which mediate trimethylation of histone H3 lysine27 (H3K27me3), as well as imbalanced contributions of parental genomes interrupt this process. The causes of the failure of cellularization are poorly understood. In this study we identified PICKLE RELATED 2 (PKR2) mutations which suppress seed abortion in fis1/mea by restoring endosperm cellularization. PKR2, a paternally expressed imprinted gene (PEG), encodes a CHD3 chromatin remodeler. PKR2 is specifically expressed in syncytial endosperm and its maternal copy is repressed by FIS1. Seed abortion in a paternal genome excess interploidy cross was also partly suppressed by pkr2. Simultaneous mutations in PKR2 and another PEG, ADMETOS (ADM), additively rescue the seed abortion in fis1 and in the interploidy cross, suggesting that PKR2 and ADM modulate endosperm cellularization independently and reproductive isolation between plants of different ploidy is established by imprinted genes. Genes upregulated in fis1 and downregulated in the presence of pkr2 are enriched in glycosyl‐hydrolyzing activity, while genes downregulated in fis1 and upregulated in the presence of pkr2 are enriched with microtubule motor activity, consistent with the cellularization patterns in fis1 and the suppressor line. The antagonistic functions of FIS1 and PKR2 in modulating endosperm development are similar to those of PICKLE (PKL) and CURLY LEAF (CLF), which antagonistically regulate root meristem activity. Our results provide further insights into the function of imprinted genes in endosperm development and reproductive isolation.
Draft Genome Sequence of Klebsiella pneumoniae AWD5
Authors: Rajkumari Jina , Singha L. Paikhomba , Pandey Piyush 
Published: February 2017

ABSTRACT

Here, we report the draft genome sequence of
Klebsiella pneumoniae
strain AWD5, isolated from an automobile workshop in India. The
de novo
assembly resulted in a 4,807,409 bp genome containing 25 rRNA genes, 81 tRNAs, and 4,636 coding sequences (CDS). It carries important genes for polyaromatic hydrocarbon degradation and benzoate degradation.