bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antigen‐Free Radionuclide‐Embedded Gold Nanoparticles for Dendritic Cell Maturation, Tracking, and Strong Antitumor Immunity
Authors: Lee Sang Bong , Lee Young Ju , Cho Sung Jin , Kim Sang Kyoon , Lee Sang‐Woo , Lee Jaetae , Lim Dong‐Kwon , Jeon Yong Hyun 
Published: January 2018

AbstractDendritic cell (DC)‐based cancer immunotherapy requires efficient maturation of DCs and sensitive monitoring of DCs localized in the lymph nodes that activate T cells. This paper reports a robust and simple surface chemistry for highly sensitive and stable radionuclide‐embedded gold nanoparticles (Poly‐Y‐RIe‐AuNPs) prepared with oligotyrosine‐modified AuNPs with additional Au shell formation as a promising positron emission tomography/computed tomography imaging agent. The multiple oligotyrosine binding sites modified on AuNPs provide excellent stability for conjugated radioisotopes by forming an Au shell. They can be heavily conjugated with radioisotope iodine, which enables sensitive tracking of DCs in the lymphatic system. More importantly, it is found that the maturation of DCs is possible solely with Poly‐Y‐RIe‐AuNPs without any additional stimulus for DC maturation. DCs matured by Poly‐Y‐RIe‐AuNPs induce antitumor immunity to cervical cancer comparable to that produced from DCs pulsated with tumor lysates. These results demonstrate that the peptide‐based surface chemistry of Poly‐Y‐RIe‐AuNPs is a simple and straightforward method to produce a highly sensitive and stable nuclear medicine imaging agent that also improves the efficiency of current antitumor immunotherapies.
Zero‐Depth Interfacial Nanopore Capillaries
Authors: Arjmandi‐Tash Hadi , Bellunato Amedeo , Wen Chenyu , Olsthoorn René C. , Scheicher Ralph H. , Zhang Shi‐Li , Schneider Grégory F. 
Published: January 2018

AbstractHigh‐fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, nanocapillaries of zero depth are formed by dissolving two superimposed and crossing metallic nanorods, molded in polymeric slabs. In an electrolyte, the interface shared by the crossing fluidic channels is mathematically of zero thickness and defines the narrowest constriction in the stream of ions through the nanopore device. This novel architecture provides the possibility to design nanopore fluidic channels, particularly with a robust 3D architecture maintaining the ultimate zero thickness geometry independently of the thickness of the fluidic channels. With orders of magnitude reduced biomolecule translocation speed, and lowered electronic and ionic noise compared to nanopores in 2D materials, the findings establish interfacial nanopores as a scalable platform for realizing nanofluidic systems, capable of single‐molecule detection.
Solid Electrolyte Layers by Solution Deposition
Authors: Lim Hee‐Dae , Lim Hyung‐Kyu , Xing Xing , Lee Byoung‐Sun , Liu Haodong , Coaty Christopher , Kim Hyungjun , Liu Ping 
Published: January 2018

AbstractSolid state batteries hold the promise of enhanced safety and higher energy density over conventional lithium‐ion batteries with flammable organic electrolytes. However, advancement of solid electrolyte materials has yet to translate into practical batteries due to the need to process the powders into thin sheets with high pressure compaction and high temperature sintering. Here, a new strategy is developed for synthesizing sulfide‐based solid electrolyte using low‐temperature solution processing, which is a simple and potentially cost‐effective way to make a thin solid electrolyte layer. By controlling the stoichiometric ratio of Li2S and S, soluble polysulfides are produced in diethylene glycol dimethyl ether, which are reacted with P2S5 to form a conductive Li3PS4 solid electrolyte. It is demonstrated that a dense solid electrolyte layer can be directly formed on Li metal with a high quality electrolyte/electrode interface, producing a solid electrolyte with promising electrochemical performance. Also, first‐principles calculations are conducted to elucidate the formation mechanisms behind the soluble intermediates and the solid electrolyte layers.
Fracture‐Induced Mechanoelectrical Sensitivities of Paper‐Based Nanocomposites
Authors: Zhang Jinyuan , Lee Gil‐Yong , Cerwyn Chiew , Yang Jinkyu , Fondjo Fabrice , Kim Jong‐Hoon , Taya Minoru , Gao Dayong , Chung Jae‐Hyun 
Published: January 2018

AbstractNanostructured composites built with microporous cellulose fibers and carbon nanotubes (CNTs) have potential impacts in the fields of energy storage, sensors, and flexible electronics. Few results have been shown for high mechanoelectrical sensitivity of CNT‐paper composite because of numerous current paths in the network. Here, CNT‐paper‐based nanostructured composite sensors whose sensitivities are generated by controlled tensile fracture of the composite are presented. Under uniaxial load, the cellulose fibers in the paper experience straightening, stiffening, and fracture. The cellulose fibers originally parallel to the tension are fractured while those inclined and perpendicular to the tension are reorganized to form crossbar junctions in the vicinity of a crack. The cross junctions exhibit resistive and capacitive sensitivity to the out‐of‐plane force by the compression of the junctions. Such piezoresistive and piezocapacitive sensitivities are characterized and evaluated for human behavior monitoring.
Lead Halide Perovskite Based Microdisk Lasers for On‐Chip Integrated Photonic Circuits
Authors: Wang Shuai , Liu Yilin , Li Gang , Zhang Jing , Zhang Nan , Xiao Shumin , Song Qinghai 
Published: January 2018

AbstractOrganic–inorganic lead halide perovskites (MAPbX3, MA = CH3NH3, X = Br, Cl, I) are intensively studied due to their unique properties and potential applications in optoelectronic devices. However, up to now, the MAPbX3 microdevices such as solar cells, lasers, and photodetectors are studied individually and their potentials in optical integration are rarely explored. Herein it is experimentally demonstrated that MAPbBr3 microdisks can be directly coupled to MAPbBr3 bus waveguides, enabling the possibility of all‐perovskite photonic networks for the first time. The MAPbBr3 microdisks with bus waveguides are fabricated with a well‐controlled top‐down fabrication technique and their laser characteristics are determined through optical excitations. In contrast to an isolated device, the lasers in perovskite microdisks can be coupled to bus waveguides via the evanescent coupling. In addition, it is shown that the outputs along bus waveguide can be switched from bidirectional emissions to unidirectional emission by introducing internal chirality to optical resonances. Considering the wide applications of perovskites in microlasers, waveguides, solar cells, and even photodetectors, this research shall pave a new way to all‐perovskite‐based self‐powered on‐chip photonic circuits.
Copper‐Catalyzed Cross‐Coupling of Secondary α‐Haloamides with Terminal Alkynes: Access to Diverse 2,3‐Allenamides
Authors: Lv Yunhe , Pu Weiya , Zhu Xueli , Zhao Tiantian , Lin Feifei 
Published: January 2018

AbstractA copper‐catalyzed C(sp)−C(sp3) cross‐coupling of terminal alkynes with readily available secondary α‐haloamides for the efficient synthesis of 2,3‐allenamides is realized. The methodology is characterized by its wide substrate scope, which makes it an important complement to traditional methods for synthesizing allenes. A mechanism involving an alkynylcopper species is proposed.magnified image
3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis
Authors: Qian Yun , Song Jialin , Zhao Xiaotian , Chen Wei , Ouyang Yuanming , Yuan Weien , Fan Cunyi 
Published: January 2018

AbstractTreating peripheral nerve injury faces major challenges and may benefit from bioactive scaffolds due to the limited autograft resources. Graphene oxide (GO) has emerged as a promising nanomaterial with excellent physical and chemical properties. GO has functional groups that confer biocompatibility that is better than that of graphene. Here, GO/polycaprolactone (PCL) nanoscaffolds are fabricated using an integration molding method. The nanoscaffolds exhibit many merits, including even GO nanoparticle distribution, macroporous structure, and strong mechanical support. Additionally, the process enables excellent quality control. In vitro studies confirm the advantages of the GO/PCL nanoscaffolds in terms of Schwann cell proliferation, viability, and attachment, as well as neural characteristics maintenance. This is the first study to evaluate the in vivo performance of GO‐based nanoscaffolds in this context. GO release and PCL biodegradation is analyzed after long‐term in vivo study. It is also found that the GO/PCL nerve guidance conduit could successfully repair a 15 mm sciatic nerve defect. The pro‐angiogenic characteristic of GO is evaluated in vivo using immunohistochemistry. In addition, the AKT‐endothelial nitric oxide synthase (eNOS)‐vascular endothelial growth factor (VEGF) signaling pathway might play a major role in the angiogenic process. These findings demonstrate that the GO/PCL nanoscaffold efficiently promotes functional and morphological recovery in peripheral nerve regeneration, indicating its promise for tissue engineering applications.
High Performance Multiwall Carbon Nanotube–Insulator–Metal Tunnel Diode Arrays for Optical Rectification
Authors: Anderson Erik C. , Bougher Thomas L. , Cola Baratunde A. 
Published: January 2018

AbstractThis work reports important fundamental advancements in multiwall carbon nanotube (MWCNT) rectenna devices by creating and optimizing new diode structures to allow optical rectification with air‐stable devices. The incorporation of double‐insulator layer tunnel diodes, fabricated for the first time on MWCNT arrays, enables the use of air‐stable top metals (Al and Ag) with excellent asymmetry for rectification applications. Asymmetry is increased by as much as 10 times, demonstrating the effectiveness of incorporating multiple dielectric layers to control electron tunneling in MWCNT diode structures. MWCNT tip opening also reduces device resistance up to 75% due to an increase in diode contact area to MWCNT inner walls. This effect is consistent for different oxide materials and thicknesses. A number of insulator layers, including Al2O3, HfO2, TiO2, ZnO, and ZrO2, in both single‐ and then double‐insulator configurations are tested. Resistance increases exponentially with insulator thickness and decreases with electron affinity. These results are used to characterize double‐insulator diode performance. Finally, for the most asymmetric device structure, Al2O3‐HfO2 (4/4 nm), optical rectification at a frequency of 470 THz (638 nm) is demonstrated. These results open the door for designing efficient MWCNT rectenna devices with more material flexibility, including air‐stable, transparent, and conductive top electrode materials.
Luminescence Imaging Characterization of Perovskite Solar Cells: A Note on the Analysis and Reporting the Results
Authors: Soufiani Arman Mahboubi , Kim Jincheol , Ho‐Baillie Anita , Green Martin , Hameiri Ziv 
Published: January 2018

AbstractIn this essay, the authors use two properly encapsulated high‐efficiency mesoscopic perovskite solar cells (PSCs), which use a state‐of‐the‐art perovskite composition (HC(NH2)2PbI3)0.85(CH3NH3PbBr3)0.15 with excess PbI2 as the active layer, to demonstrate the potential effect of dynamical electroluminescence responses on the analysis and interpretation of PSCs electrical characteristic. The essay does not aim to determine how to overcome this issue, nor to investigate its physical/chemical origin, although tentative propositions are made; but rather, to warn researchers in the field about the interpretation and reporting the results obtained from luminescence imaging measurements and the effect of image collection timing on the results. This is a critical message since the authors predict that luminescence imaging techniques will soon become one of the key tools for PSCs characterization, both for long‐term stability assessment and fabrication process optimization.
Recent Progress of the Solid‐State Electrolytes for High‐Energy Metal‐Based Batteries
Authors: Fan Lei , Wei Shuya , Li Siyuan , Li Qi , Lu Yingying 
Published: January 2018

AbstractSecondary batteries based on metal anodes (e.g., Li, Na, Mg, Zn, and Al) are among the most sought‐after candidates for next‐generation mobile and stationary storage systems because they are able to store a larger amount of energy per unit mass or volume. However, unstable electrodeposition and uncontrolled interfacial reactions occuring in liquid electrolytes cause unsatisfying cell performance and potential safety concerns for the commercial application of these metal anodes. Solid‐state electrolytes (SSEs) having a higher modulus are considered capable of inhibiting difficulties associated with the anodes and may enable building of safe all‐solid‐state metal batteries, yet several challenges, such as insufficient room‐temperature ionic conductivity and poor interfacial stability between the electrode and the electrolyte, hinder the large‐scale development of such batteries. Here, research and development of SSEs including inorganic ceramics, organic solid polymers, and organic–inorganic hybrid/composite materials for metal‐based batteries are reviewed. The comparison of different types of electrolytes is discussed in detail, in the context of electrochemical energy storage applications. Then, the focus of this study is on recent advances in a range of attractive and innovative battery chemistries and technologies that are enabled by SSEs. Finally, the challenges and future perspectives are outlined to foresee the development of SSEs.
From Molecular Packing Structures to Electronic Processes: Theoretical Simulations for Organic Solar Cells
Authors: Han Guangchao , Yi Yuanping , Shuai Zhigang 
Published: January 2018

AbstractMolecular packing structures in the active layers have a crucial impact on the electronic processes for organic solar cells. To date, however, it is still difficult to probe molecular self‐assembling and packing structures at the atomic level by experimental techniques, which is hindering reliable understanding of the structure–property relationship. Accordingly, theoretical simulations provide a useful tool and are becoming more and more important. Here, recent advances in theoretical simulations for organic solar cells are reviewed. First, a brief introduction of theoretical methodologies, including the strategies of molecular dynamics simulations of active‐layer processing procedures and quantum‐chemical methods for calculating electron transfer processes, is given. Then, the influences of molecular packing structures on charge generation, charge recombination, and charge transport are analyzed and discussed from a theoretical perspective. Finally, prospects and challenges are pointed out for theoretical prediction of the electrical characteristics and photoelectric conversion efficiencies of organic solar cells from molecular structures.
Natural Leaf Made Triboelectric Nanogenerator for Harvesting Environmental Mechanical Energy
Authors: Jie Yang , Jia Xueting , Zou Jingdian , Chen Yandong , Wang Ning , Wang Zhong Lin , Cao Xia 
Published: January 2018

AbstractDistributed environmental mechanical energy is rarely collected due to its fluctuating amplitudes and low frequency, which is usually attributed as “random” energy. Considering the rapid development of the Internet of things (IoT), there is a great need for a large number of distributed and sustainable power sources. Here, a natural leaf assembled triboelectric nanogenerator (Leaf‐TENG) is designed by utilizing the green leaf as an electrification layer and electrode to effectively harvest environmental mechanical energy. The Leaf‐TENG with good adaptability has the maximum output power of ≈45 mW m−2, which is capable of driving advertising LEDs and commercial electronic temperature sensors. Besides, a tree‐shaped energy harvester is integrated with natural Leaf‐TENG to harvest large‐area environmental mechanical energy. This work provides a new prospect for distributed and environmental‐friendly power sources and has potential applications in the IoT and self‐powered systems.
Asymmetric Synthesis of Indoline–Benzodiazepine Scaffold Catalyzed by Chiral Imidodiphosphoric Acids
Authors: Gao Jigang , Chen Yingying , Zhou Tianyun , Liu Guofeng , An Dong , Zhuo Minghua , Zhang Guangliang , Zhang Suoqin 
Published: January 2018

AbstractChiral indoline–benzodiazepines were synthesized via an enantioselective Pictet–Spengler‐type reaction catalyzed by chiral imidodiphosphoric acids. A variety of substitution patterns were achieved at room temperature by using 5 mol % catalysts with high yields (up to 97 %) and enantioselectivities (up to 99 % ee).
A Versatile Ligand Platform for Palladium‐ and Nickel‐Catalyzed Ethylene Copolymerization with Polar Monomers
Authors: Chen Min , Chen Changle 
Published: January 2018

AbstractThe ability to carry out transition‐metal‐catalyzed copolymerizations of olefins with polar monomers is a great challenge in the field of olefin polymerization. Palladium has been the dominant player in this field, while its low‐cost nickel counterpart has only achieved very limited success. We report the synthesis and evaluation of a highly versatile platform based on diphosphazane monoxide ligands. Both palladium and nickel catalysts bearing these ligands mediate the copolymerization of ethylene with a number of fundamental polar monomers.
Fluoroethylene Carbonate Enabling a Robust LiF‐rich Solid Electrolyte Interphase to Enhance the Stability of the MoS2 Anode for Lithium‐Ion Storage
Authors: Zhu Zhiqiang , Tang Yuxin , Lv Zhisheng , Wei Jiaqi , Zhang Yanyan , Wang Renheng , Zhang Wei , Xia Huarong , Ge Mingzheng , Chen Xiaodong 
Published: January 2018

AbstractAs a high‐capacity anode for lithium‐ion batteries (LIBs), MoS2 suffers from short lifespan that is due in part to its unstable solid electrolyte interphase (SEI). The cycle life of MoS2 can be greatly extended by manipulating the SEI with a fluoroethylene carbonate (FEC) additive. The capacity of MoS2 in the electrolyte with 10 wt % FEC stabilizes at about 770 mAh g−1 for 200 cycles at 1 A g−1, which far surpasses the FEC‐free counterpart (ca. 40 mAh g−1 after 150 cycles). The presence of FEC enables a robust LiF‐rich SEI that can effectively inhibit the continual electrolyte decomposition. A full cell with a LiNi0.5Co0.3Mn0.2O2 cathode also gains improved performance in the FEC‐containing electrolyte. These findings reveal the importance of controlling SEI formation on MoS2 toward promoted lithium storage, opening a new avenue for developing metal sulfides as high‐capacity electrodes for LIBs.
Stress reactivity and pain‐mediated stress regulation in remitted patients with borderline personality disorder
Authors: Willis Franziska , Kuniss Sarah , Kleindienst Nikolaus , Lis Stefanie , Naoum Janina , Jungkunz Martin , Neukel Corinne , Bohus Martin , Treede Rolf‐Detlef , Baumgärtner Ulf , Schmahl Christian 
Published: January 2018

AbstractObjectivePatients with borderline personality disorder (BPD) use nonsuicidal self‐injury (NSSI) to cope with states of elevated inner tension. It is unclear to what extent remitted BPD patients experience these states and whether the experience of pain still regulates emotion. The purpose of this study was the investigation of baseline stress levels, stress reactivity, and pain‐mediated stress regulation in remitted BPD patients.MethodSubjective and objective stress parameters were assessed in 30 remitted BPD patients, 30 current BPD patients, and 30 healthy controls. After stress induction, a non‐nociceptive tactile stimulus, a tissue‐injuring, or a noninvasive pain stimulus was applied to the right volar forearm.ResultsBaseline stress levels of remitted BPD patients lie in between the stress levels of current BPD patients and healthy controls. Urge for NSSI increased significantly more in current than remitted BPD patients. The experience of pain led to a greater decrease of arousal in current compared to remitted BPD patients and healthy controls.ConclusionsStates of increased tension still seem to appear in remitted BPD patients. The role of pain‐mediated stress regulation appears to be reduced in remitted patients.
Iatrogenic seeding of osteosarcoma in a tracheotomy tract – a case report
Authors: Duek Irit , Lopchinsky Richard , Akrish Sharon , Gil Ziv 
Published: January 2018

Key Clinical MessageHere, we describe the first reported case of osteosarcoma occurring postsurgically in a tracheotomy tract, highlighting the possibility of osteosarcoma seeding during head and neck surgery. Preventative measures such as performing the tracheostomy after the tumor resection while walling off the tracheostomy site from the operative field should be considered.
Self‐Assembling of Fmoc‐GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates
Authors: Avitabile Concetta , Diaferia Carlo , Della Ventura Bartolomeo , Mercurio Flavia Anna , Leone Marilisa , Roviello Valentina , Saviano Michele , Velotta Raffaele , Morelli Giancarlo , Accardo Antonella , Romanelli Alessandra 
Published: January 2018

AbstractThe study of molecules that self‐assemble through noncovalent interactions is one of the most attractive topics in supramolecular chemistry. The use of short peptides or modified nucleotides as building blocks for the aggregates is particularly intriguing because these are very easy to synthesize; moreover, subtle changes in the chemical structure of such building blocks may drastically affect the properties of the aggregates. The ability of peptide nucleic acids (PNA) to aggregate has been very little explored, despite its practical applications. In this work we investigated the self‐assembling properties of a PNA dimer, conjugated at the N‐terminus to a fluorenylmethoxycarbonyl group. This PNA dimer forms nano‐aggregates at low concentration in CHCl3/CH3OH mixtures. The aggregates retain very interesting fluorescent properties (high quantum yield in the visible region with lifetimes on the nanosecond scale), which make them promising materials for applications in optoelectronics.
Catalytic Dearomative Spirocyclization via Gold Carbene Species Derived from Ynamides: Efficient Synthesis of 2‐Azaspiro[4.5]decan‐3‐ones
Authors: Ito Mamoru , Kawasaki Ryosuke , Kanyiva Kyalo Stephen , Shibata Takanori 
Published: January 2018

AbstractAn intramolecular catalytic dearomatization of phenols via gold carbene species proceeded to provide 2‐azaspiro[4.5]decan‐3‐ones. The use of NHC ligand and water as a co‐solvent was critical for achieving high reactivity. This reaction did not require hazardous diazo compounds as carbene sources and proceeded even under air. The obtained spirocyclic product could be readily transformed into a gabapentin derivative by hydrogenation and deprotection.