bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central Bank Intervention, Exchange Rate Regime and the Purchasing Power Parity
Authors: Lin Luke , Lee Chun I. 
Published: January 2016

AbstractMotivated by the argument that central bank intervention leads to non‐linear exchange rate adjustment processes, we examine purchase power parity (PPP) by applying quantile unit root tests to the exchange rates of the New Taiwan Dollar (NTD)vis‐à‐visseven Asian currencies. We show that exchange rate regime matters in determining whetherPPPholds. WhilePPPholds overwhelmingly during the period when theNTDis under the fixed exchange rate regime, it is present only for some exchange rates during the managed floating rate regime. For exchange rates exhibiting mean reversion, the reversion occurs mainly when the shocks are large. In contrast to conclusion in the literature, our test results show little evidence of asymmetric mean reversion between positive and negative shocks.
Physical Activity, Physical Fitness, and Health-Related Quality of Life in School-Aged Children
Authors: Gu Xiangli , Chang Mei , Solmon Melinda A. 
Published: January 2016

Purpose:This study examined the association between physical activity (PA), physical fitness, and health-related quality of life (HRQOL) among school-aged children.Methods:Participants were 201 children (91 boys, 110 girls; Mage = 9.82) enrolled in one school in the southern US. Students’ PA (self-reported PA, pedometer-based PA) and physical fitness (cardiorespiratory fitness, muscular fitness, flexibility, and body composition) were assessed in the fall. The PedsQL4.0 (Varni et al., 2001) was used to assess participants’ HRQOL (physical and mental function) in the spring.Results:PA and four components of physical fitness were positively associated with physical and mental function. Path analyses suggested physical fitness mediated the relationship between self-reported PA and HRQOL (95% CI: [.53, 1.48]), as well as between pedometer-based PA and HRQOL (95% CI: [.54, 1.53]).Discussion:Results support the conclusion that enhancing children’s physical fitness can facilitate positive outcomes including improved health related quality of life.
Living Wires — Effects of Size and Coating of Gold Nanoparticles in Altering the Electrical Properties ofPhysarum polycephalumand Lettuce Seedlings
Authors: Gizzie Nina , Mayne Richard , Yitzchaik Shlomo , Ikbal Muhamad , Adamatzky Andrew 
Published: January 2016

The manipulation of biological substrates is becoming more popular route toward generating novel computing devices. Physarum polycephalum is used as a model organism in biocomputing because it can create “wires” for use in hybrid circuits; programmable growth by manipulation through external stimuli and the ability withstanding a current and its tolerance to hybridization with a variety of nano/microparticles. Lettuce seedlings have also had previous interest invested in them for generating plant wires, although currently there is little information as to their suitability for such applications. In this study both P. polycephalum and Lettuce seedlings were hybridized with gold nanoparticles — functionalized and unfunctionalized — to explore their uptake, toxicological effects and, crucially, any alterations in electrical properties they bestow upon the organisms. Using various microscopy techniques it was shown that P. polycephalum and lettuce seedlings are able to internalize nanoparticles and assemble them in vivo, however some toxicological effects were observed. The electrical resistance of both lettuce seedlings and P. polycephalum was found to decrease, the most significant reduction being with lettuce seedlings whose resistance reduced from 3[Formula: see text]M[Formula: see text]s to 0.5[Formula: see text]M[Formula: see text]s. We conclude that gold is a suitable nanomaterial for biohybridization specifically in creating conductive pathways for more efficient biological wires in self-growing hybrid circuitry.
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway
Authors: Jiang Yan , Pan Yong , Rhea Patrea R. , Tan Lin , Gagea Mihai , Cohen Lorenzo , Fischer Susan M. , Yang Peiying 
Published: January 2016

Abstract
Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved. We found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and metastasis, when compared with a nonsugar starch diet. This effect was ascribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE). We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumors. Overall, our data suggested that dietary sugar induces 12-LOX signaling to increase risks of breast cancer development and metastasis. Cancer Res; 76(1); 24–29. ©2016 AACR.
Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death
Authors: Zimmerman Eric I. , Gibson Alice A. , Hu Shuiying , Vasilyeva Aksana , Orwick Shelley J. , Du Guoqing , Mascara Gerard P. , Ong Su Sien , Chen Taosheng , Vogel Peter , Inaba Hiroto , Maitland Michael L. , Sparreboom Alex , Baker Sharyn D. 
Published: January 2016

AbstractThe use of multikinase inhibitors (MKI) in oncology, such as sorafenib, is associated with a cutaneous adverse event called hand–foot skin reaction (HFSR), in which sites of pressure or friction become inflamed and painful, thus significantly impacting quality of life. The pathogenesis of MKI-induced HFSR is unknown, and the only available treatment options involve dose reduction or discontinuation of therapy, which have negative effects on primary disease management. To investigate the underlying mechanisms by which sorafenib promotes keratinocyte cytotoxicity and subsequent HFSR induction, we performed a transporter-directed RNAi screen in human epidermal keratinocytes and identified SLC22A20 (OAT6) as an uptake carrier of sorafenib. Further investigations into the intracellular mechanism of sorafenib activity through in situ kinome profiling identified the mitogen-activated protein kinase MAP3K7 (TAK1) as a target of sorafenib that induces cell death. Finally, we demonstrate that sorafenib induced keratinocyte injury in vivo and that this effect could be reversed by cotreatment with the OAT6 inhibitor probenecid. Collectively, our findings reveal a novel pathway that regulates the entry of some MKIs into keratinocytes and explains the basis underlying sorafenib-induced skin toxicity, with important implications for the therapeutic management of HFSR. Cancer Res; 76(1); 117–26. ©2015 AACR.
Earnings Growth and Value Premium: The Indian Experience
Authors: Saji T G , Harikumar S 
Published: January 2016

Executive Summary This article addresses two main questions: Does a value premium exist in emerging market like India? If so, how pervasive is it in different market conditions? Value premium is assumed to be the difference in stock returns of undervalued and overvalued firms with a unique industry profile. The sample for the study consisted of 32 companies from the Information Technology (IT) sector, the stocks of which had traded continuously in the National Stock Exchange (NSE) during the period 2000–2010. Prowess and Capitaline constitute the sources for the firm-level financial data, and NSE web sources provide data related to share prices and market capitalization. The study involved a two-step empirical procedure: an exploratory factor analysis and a regression modelling under Ordinary Least Square (OLS) method. Exploratory factor analysis identified earnings growth and Earnings Price (E/P) rate as the prime determinants of stock returns. Expected earnings growth significantly explained E/P rate under OLS regression framework. The study then estimated normal E/P rate for the individual stock and compared the same with the actual E/P. If the actual E/P for a particular stock was greater than its estimated E/P, it was inferred that the stock was undervalued, the reverse being the case for overvaluation. The findings of this research provide empirical validity of use of E/P rate in identifying mispriced stocks in the Indian context. Undervalued stocks can produce better returns compared to overvalued stocks, and their success has been both persistent and impressive. E/P rate or P/E ratio is a valuable analytic device when properly interpreted. The publicly available E/P rate seems to possess information content and warrants an investor’s attention at the time of his portfolio formation or revision. The search process involving E/P rate suggests that the best buy would be the stock whose reported earnings per share is expected to grow most rapidly.
The power of language: Use in psychiatry
Authors: El-Mallakh Rif S. , Doenninghaus Sabine 
Published: January 2016

SummaryLanguage dictates how individuals process and understand concepts. This
phenomenon is examined for the terms ‘antipsychotic’ and ‘antidepressant’.
When the use of medications is extended in new directions (for example when
an antipsychotic is used as an antidepressant), the name not only loses its
utility, but may become an obstacle to treatment. Clinicians need to be
aware of these issues.
Research into hallucinations and psychotic-like symptoms in
children: Implications for child psychiatric practice
Authors: Garralda M. Elena 
Published: January 2016

SummaryThere is a growing research interest in childhood hallucinations as
predictors of psychotic states. This work appears to have limited direct
relevance for clinical child psychiatric practice, but it highlights the
continuing relevance of research into precursors of psychotic states and
into the determinants of clinically relevant hallucinations in children.
Resting vagal activity in schizophrenia: Meta-analysis of heart
rate variability as a potential endophenotype
Authors: Clamor Annika , Lincoln Tania M. , Thayer Julian F. , Koenig Julian 
Published: January 2016

BackgroundCardiac vagal tone, indexed by heart rate variability (HRV), is a proxy
for the functional integrity of feedback mechanisms integrating central
and peripheral physiology.AimsTo quantify differences in HRV in individuals with schizophrenia compared
with healthy controls.MethodDatabases were systematically searched for studies eligible for
inclusion. Random effect meta-analyses of standardised mean differences
were calculated for vagal activity indicated by high-frequency HRV and
the root mean square of successive R–R interval differences (RMSSD).ResultsThirty-four studies were included. Significant main effects were found
for high-frequency HRV (P = 0.0008; Hedges'
g =–0.98, 95% CI −1.56 to −0.41, k =
29) and RMSSD (P<0.0001; g =–0.91,
95% CI −1.19 to −0.62, k = 24), indicating lower vagal
activity in individuals with schizophrenia than in healthy controls.
Considerable heterogeneity was evident but effects were robust in
subsequent sensitivity analyses.ConclusionsGiven the association between low HRV, threat processing, emotion
regulation and executive functioning, reduced vagal tone may be an
endophenotype for the development of psychotic symptoms.
Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency
Authors: Rasmussen Michael Højby , Janukonyté Jurgita , Klose Marianne , Marina Djordje , Tanvig Mette , Nielsen Lene F. , Höybye Charlotte , Andersen Marianne , Feldt-Rasmussen Ulla , Christiansen Jens Sandahl 
Published: January 2016

Abstract

Context:
NNC0195-0092 is a reversible, albumin-binding GH derivative, developed for once-weekly administration.

Objectives:
The objective of the study was to evaluate safety, local tolerability, pharmacodynamics, and pharmacokinetics of multiple, once-weekly doses of NNC0195-0092, compared with daily GH.

Design and Setting:
This was a phase 1, randomized, open-label, active-controlled, multiple-dose, dose-escalation trial.

Patients:
Thirty-four GH-treated adult subjects (male, n = 25) with GH deficiency participated in the study.

Interventions and Main Outcome Measures:
Subjects were sequentially assigned into four cohorts of eight subjects, randomized within each cohort (3:1) to once-weekly NNC0195-0092 (n = 6) for 4 weeks (0.02, 0.04, 0.08, and 0.12 mg/kg) or daily injections of Norditropin NordiFlex (n = 2) for 4 weeks with a dose replicating the pretrial dose of somatropin. A safety assessment was performed prior to initiating treatment at the next dose level of NNC0195-0092. Daily GH treatment was discontinued 14 days before the trial start. Blood samples were drawn for assessment of safety, pharmacokinetics, pharmacodynamics (IGF-1 and IGF-binding protein-3) profiles, and immunogenicity studies.

Results:
Numbers of adverse events were similar at the dose levels of 0.02, 0.04, and 0.08 mg/kg NNC0195-0092 vs daily injections of Norditropin NordiFlex, whereas the number of adverse events was greater at the highest dose level of NNC0195-0092 (0.12 mg/kg). NNC0195-0092 (area under the curve[0–168h]) and peak plasma concentration) increased in a dose-dependent manner, and a dose-dependent increase in IGF-1 levels was observed. IGF-1 profiles were elevated for at least 1 week, and for the 0.02-mg/kg and 0.04-mg/kg NNC0195-0092 doses, the observed IGF-1 levels were similar to the levels for the active control group.

Conclusion:
Four once-weekly doses of NNC0195-0092 (dose range 0.02–0.12 mg/kg) administered to adult patients with GH deficiency were well tolerated, and IGF-1 profiles were consistent with a once-weekly treatment profile. No clinically significant safety and tolerability signals causally related to NNC0195-0092 were identified, nor were any immunogenicity concerns revealed.
Surface Control of a Photoresponsive Self-Assembled Monolayer and Selective Deposition of Ag Nanoparticulate Ink
Authors: Konishi Tsubasa , Yamaguchi Kazuo 
Published: January 2016

Abstract
A highly hydrophobic self-assembled monolayer (SAM) with high photosensitivity to soft UV (λ = 365 nm) was formed on thermally surface-oxidized silicon wafers by a silane coupling agent bearing a 2-nitrobenzyl carbamate moiety. Very smooth SAM was obtained by the use of 1,3-bis(trifluoromethyl)benzene as a solvent. Photopatterning of the SAM was carried out by irradiation with soft UV at 2 J cm−2 (80 s) in acetone under a photomask. Selective deposition of Ag nanoparticulate ink by spin coating on the resulting patterned surface afforded a well-defined 10 µm line and space pattern. Subsequent photodeprotection to generate amino groups enabled the space regions to be selectively modified with fluorescent dye bearing a succinimidyl ester moiety.
Case Report: Ischaemic appendicitis post mesenteric biopsy
Authors: Zukiwskyj Marianna , Tun June , Desai Shashank 
Published: January 2016

A common indication for laparoscopic mesenteric lymph node biopsy is to provide a tissue diagnosis in the absence of palpable peripheral nodes via a minimally invasive approach. There are no reports to date of ischaemia to the appendix as a complication of this procedure. We report the case of a 34-year-old lady who underwent a mesenteric biopsy for a lesion found incidentally on CT to investigate longstanding abdominal pain, and 2 days later required an appendicectomy for ischaemic appendicitis.
Job satisfaction among workers in the libraries of the University of Guelma – Algeria
Authors: Chabounia Omar 
Published: January 2016

The aim of this study is to measure satisfaction level of Guelma university librarians in relation to job factors (salary, advancement, bebefits) and organizational factors (leadership, communcation, colleague of job) and nature of job.
This study also aims to investigate the relation between job satisfaction and some demographic variables. The sample of this study consist of all employees staff in Guelma university libraries (60 employees).
The study used JSS method to measure job satisfaction level by using the questionnaire as research instrument.
The results indicated that ; both of job factors and organizational factors have impact- ralation with satisfaction level, also there’nt significant differences in job satisfaction regarding to demographic variables.
The relationship among academic expectations, academic satisfaction and career planning: The sample of tourism undergraduate students<p>Akademik beklenti, akademik memnuniyet ve kariyer planlaması ilişkisi: Turizm lisans öğrencileri örneği
Authors: Demir Mahmut , Demir Şirvan Şen 
Published: January 2016

<p class="zet">Higher education institutions have an important role in the career planning of individuals. But, student selection examinations is the most important factor for their choosing school and directly or indirectly affect their career choices, and their expectations and satisfaction levels can cause positive or negative results. In term of 2013-2014, data for this study were collected from the students of thefourthgradestudents intourism undergraduateeducation at state universities in Turkey. The purposes of this study was to compare the academic expectations from the institutions and satisfaction levels of the students with regard to academic services provided by their university and examine the relationship between expectation and satisfaction levels of the students and their career planning. Questionnaire for this study was developed from prior research and published scales on a 5-point Likert-type which was based on three dimensions. Through conducting a face-to-face interview, a total of 583 questionnaires were collected from students. PASW was used to analyze the data that includes various statistical tools such as factor analysis, correlation analysis and regression analysis. As a result, the findings indicate that expectation and satisfaction levels have a negative correlation with each other, and these two factors have positive influence on career planning.</p><p class="zet"> </p><p class="zet"><strong>Özet</strong></p><p class="zet">Yükseköğretim kurumları, bireylerin kariyer planlamasında önemli bir yere sahiptir. Ancak, yükseköğretime giriş sınavının okul seçiminde en önemli faktör olarak görülmesi, bireylerin kariyer tercihlerini doğrudan ya da dolaylı olarak etkilemekte ve bu durum onların beklenti ve memnuniyet düzeylerine bağlı olarak olumlu ya da olumsuz sonuçlar doğurabilmektedir. Türkiye’deki kamu üniversitelerinde 2012-2013 eğitim öğretim yılında, turizm lisans eğitimi alan dördüncü sınıf öğrencilerini kapsayan bu araştırmanın amacı, kurumlarından akademik beklentileri ile onlara sağlanan akademik hizmetlerden memnuniyet düzeylerini karşılaştırmak ve kariyer planlaması ile ilişkisini ortaya koymaktır. Konuyla ilgili literatürden yararlanılarak, beklenti, memnuniyet ve kariyer planlamasına yönelik beşli Likert türü bir anket formu oluşturulmuştur. Yüz yüze görüşme yöntemi ile 583 adet anket formu toplanmıştır. Verilerin analizinde PASW istatistik programı kullanılarak değişkenlere faktör analizi, korelasyon ve çoklu regresyon analizi uygulanmıştır. Sonuçta, bireylerin beklentileri ile memnuniyet düzeylerinin ters yönlü bir ilişkisi olduğu, aynı zamanda bu iki temel faktörün kariyer planlamasını etkilediği bulgusuna ulaşılmıştır.</p>
Análisis de la metodología de aprendizaje colaborativo en la impartición del módulo de Formación y Orientación Laboral (FOL).
Authors: Soto-Cid Javier , Silva-Gómez David , Lago-Cancelo María Isabel , Gómez-Cantorna Cristina , Vidal-Tubío Rosa Ana , Fernández-Vázquez Alfonso 
Published: January 2016

El proceso de enseñanza-aprendizaje en el ámbito de la formación profesional tiene como fin último la adquisición por parte del alumnado de una serie de competencias que los convertirán en profesionales cualificados para desempeñar satisfactoriamente su tarea profesional. El módulo de Formación y Orientación Laboral, presente en todos los ciclos de la Formación Profesional Inicial, se centra en una serie de competencias transversales de carácter profesional así como en capacidades y conocimientos vinculados al desempeño laboral en cualquier contexto. Dada la especificidad de este módulo formativo y la ausencia de menciones explícitas en la normativa vigente sobre la metodología más adecuada para su impartición, los autores del presente artículo nos propusimos investigar la conveniencia de utilizar mayoritariamente la metodología colaborativa. Dado que son muchos los autores que señalan entre los beneficios de esta metodología el desarrollo de habilidades socioafectivas y comunicativas analizamos a través de una investigación cualitativa la posibilidad de utilizarla en la impartición del módulo de Formación y Orientación Laboral.DOI: http://dx.doi.org/10.15304/ie.25.2302
El Aprendizaje Basado en Proyectos: un constante desafío
Authors: Rekalde Rodríguez Itziar , García Vílchez Jon 
Published: January 2016

El Aprendizaje basado en proyectos (ABPy) ha ido ganando reconocimiento hasta convertirse en una de las metodologías más utilizadas en los actuales sistemas educativos para quienes han dado el paso hacia esa forma de entender la educación y la docencia que conlleva la construcción del conocimiento a través de la interacción con la realidad. El objetivo de este trabajo consiste en desvelar los retos por los que atraviesa el profesorado de primaria que plantea el trabajo escolar a través de proyectos (ABPy), para que desde su análisis y comprensión, se establezcan líneas de reflexión que ayuden al profesorado a mejorar su práctica docente. La perspectiva metodológica es cualitativa y el método utilizado ha sido un estudio de caso donde la población objeto de estudio ha sido el profesorado de la etapa de primaria del Colegio Público Zuhaizti de Donostia-San Sebastián, con el que se han utilizado entrevistas semiestructuradas y grupos de discusión. En cuanto a los resultados más sobresalientes se destacan los retos internos que genera en el profesorado, como; la gestión de la inseguridad, los miedos, el desconcierto…, y externos, tanto didácticos, relacionados con los recursos, la evaluación, el enfoque inclusivo…, como comunicativo-relacionales destacando la coordinación de equipos docentes, y la relación con las familias y el entorno. Se concluye con líneas de reflexión que ayudan a reconducir y mejorar la práctica docente respecto a la actitud personal, coordinación institucional, participación de las familias y apertura del centro.DOI: http://dx.doi.org/10.15304/ie.25.2304
Los primeros años del Instituto de Ciencias de la Educación de la Universidad de Santiago de Compostela
Authors: Casado Linarejos Julio 
Published: January 2016

La creación de los Institutos de Ciencias de la Educación (1969) y su puesta en marcha (1970) supuso una notable innovación en el sistema educativo español. El ICE de la Universidad de Santiago (ICE-USC) inició su andadura un año antes, con carácter experimental, asumiendo las tareas de: a) formación del profesorado; b) perfeccionamiento del profesorado; c) investigación. En 1974 nace en el ICE-USC la división de Orientación educativa, con el fin de prestar asesoramiento técnico a centros, profesores y tutores del Distrito Universitario de Santiago (único en Galicia, entonces).En el ámbito de la Tecnología educativa y producción de recursos, el ICE de Santiago fue el primero de España en poner en marcha el servicio de medios audiovisuales. A través de cursos de Microenseñanza y Observación, simulaciones de comportamiento sociológico, programas de aprendizaje en EGB, didáctica de idiomas, etc., el ICE-USC se integró plenamente en las tareas de formación y perfeccionamiento del profesorado y de investigación de la Universidad de Santiago de Compostela. En este trabajo se describen sumariamente las actividades desarrolladas y su valoración por el profesorado de los diferentes niveles educativos.DOI: http://dx.doi.org/10.15304/ie.25.2900