bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic utility of renal fine-needle aspirate cytology and ultrasound in the cat
Authors: McAloney Camille A , Sharkey Leslie C , Feeney Daniel A , Seelig Davis M 
Published: July 2017

Objectives The primary objective of this study was to retrospectively assess the diagnostic utility of feline renal fine-needle aspiration cytology by assessing diagnostic yield, cytologic characteristics and diagnostic accuracy. The secondary objective was to characterize ultrasonographic features of sampled kidneys to determine if they influenced diagnostic yield. Methods Slides, images and patient data were collected from the University of Minnesota Veterinary Medical Center database. Slides were designated as diagnostic or non-diagnostic. Non-diagnostic slides were used in calculating diagnostic yield and excluded from other analysis. Slides were evaluated for cytologic characteristics and assigned a single primary diagnosis. Ultrasound still images were evaluated for descriptive characteristics and characteristics of specific lesions were described. Cases with confirmatory testing were used to determine diagnostic sensitivity, specificity and positive and negative predictive values for detecting neoplasia. Results Of 96 cytologic submissions available for review, diagnostic yield was 68%; 48% of samples were at least moderately cellular. Of 87 cases with ultrasound data, kidneys showing subcapsular renal infiltrate, diffuse renal enlargement without pelvic dilation and infiltrative/nodular change were more likely to yield diagnostic samples. Of 12 confirmed cases, cytology was 100% sensitive and specific for the detection of neoplasia (four round-cell tumors and two carcinomas). Three cases with non-neoplastic histologic diagnoses were considered cytologically normal, two incorrectly diagnosed the pathology present, and one correctly diagnosed the pathology. While some imaging characteristics were more commonly seen in neoplastic vs non-neoplastic lesions, the sample size was insufficient for definitive correlation. Conclusions and relevance This is the first major analysis of feline ultrasound-guided renal fine-needle aspiration cytology. This technique generates adequate samples for interpretation at rates comparable to other soft tissues and is most useful in the diagnosis of neoplasia. Some imaging characteristics are indicative of the likelihood of obtaining an adequate sample for cytologic interpretation.
The impact of a social network based intervention on self-management behaviours among patients with type 2 diabetes living in socioeconomically deprived neighbourhoods: a mixed methods approach
Authors: Vissenberg Charlotte , Nierkens Vera , van Valkengoed Irene , Nijpels Giel , Uitewaal Paul , Middelkoop Barend , Stronks Karien 
Published: July 2017

Aims: This paper aims to explore the effect of the social network based intervention Powerful Together with Diabetes on diabetes self-management among socioeconomically deprived patients. This 10-month group intervention targeting patients and significant others aimed to improve self-management by stimulating social support and diminishing social influences that hinder self-management. Methods: This intervention was evaluated in a quasi-experimental study using a mixed methods approach. Of 131 socioeconomically deprived patients with suboptimal glycaemic control, 69 were assigned to the intervention group and 62 to the control group (standard diabetes education). 27 qualitative in-depth interviews with the participants and 24 with their group leaders were held to study the subjective impact of the intervention. Further, self-management behaviours (medication adherence, diet and physical activity) were assessed at baseline, 10 and 16 months. Data were analysed using framework analyses and a linear mixture model. Results: Qualitative data showed that the intervention group had a better understanding of the way self-management influences diabetes. The intervention group showed more complex self-management behaviours, such as planning ahead, seeking adequate food and physical activity alternatives, and consistently taking their diabetes into consideration when making choices. In participants with complete follow-up data, we found a significant increase in physical activity in the intervention group (3.78 vs. 4.83 days) and no changes in medication adherence and diet. Conclusions: This study indicates that an intensive support group and simultaneously involving significant others might improve diabetes self-management behaviours among socioeconomically deprived patients. More studies are needed to justify further implementation of the intervention. This study is registered in the Dutch Trial Register NTR1886. http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1886
Determination of Aerobic Capacity via Cycle Ergometer Exercise Testing in Alzheimer’s Disease
Authors: Bronas Ulf G. , Salisbury Dereck , Kelly Kaitlin , Leon Arthur , Chow Lisa , Yu Fang 
Published: July 2017

Background: Older adults with Alzheimer’s disease (AD) may be unable to perform treadmill testing due to balance issues. We investigated whether older adults with AD could successfully complete a peak cycle ergometer test. Methods: Peak oxygen consumption (peak [Formula: see text]) assessed via a cycle ergometer test in 44 participants with AD (age 78.4 ± 6.8). Physical function was assessed via the incremental shuttle walk, 6-minute walk, and the Short Physical Performance Battery (SPPB). Results: All participants completed the cycle ergometer test successfully. Peak [Formula: see text] was correlated with SPPB ( r = .35, P = .023), shuttle walk ( r = .35, P = .024), 6-minute walk ( r = .31, P = .05), and inversely with age ( r = −.4, P = .009). There was no correlation between peak [Formula: see text] and cognition. Conclusion: Older adults with AD are able to safely complete a peak cycle ergometer exercise testing protocol. We provide an individualized cycle ergometer test for determining aerobic capacity in older adults with AD who may be unable to perform treadmill testing due to balance or gait issues.
Effect of Pre-Loading Oral Glucosamine HCl/Chondroitin Sulfate/Manganese Ascorbate Combination on Experimental Arthritis in Rats
Authors: Beren Joel , Hill Susan L. , Diener-West Marie , Rose Noel R. 
Published: July 2017

The therapeutic effect of a nutritional supplement consisting of a combination of glucosamine hydrochloride (FCHG49), purified sodium chondroitin sulfate (TRH122), and manganese ascorbate (GCM)3 was investigated in the rat model of collagen-induced autoimmune arthritis (CIA). The GCM compound was mixed with a palatable nutritional paste (Nutri-cal® [NC]). Oral administration of the NC/GCM compound was initiated in 26 rats 10 days before immunization and continued until the day of sacrifice. One group of 12 control rats was given no oral agents; a second group of 12 control rats received NC only. Evaluations included arthritis index (AI) scoring by three independent evaluators, histologic index (HI) scoring of lesions, T-cell proliferation, and serological studies for antibody classes and subclasses. Both the AI and HI criteria showed a statistically significant reduction in the prevalence of CIA in rats pretreated with the NC/GCM (54%) compared to the combined control groups (96%, χ2 analysis P < 0.001). Rats fed the NC/GCM also exhibited a significant decrease in the severity of autoimmune arthritis in both the AI and HI compared to control Group 2 (immunized-NC) (χ2 analysis P < 0.05). Histological studies verified the decreased incidence of arthritis in the NC/GCM group compared to control Group 2. GCM treatment failed to alter T-cell proliferation and antibody production to bovine type-II collagen, indicating that its effects are not due to alteration of the antigen-specific immune response.
Interleukin-11 Inhibits N-κB and AP-1 Activation in Islets and Prevents Diabetes Induced with Streptozotocin in Mice
Authors: Lgssiar Abdelhakim , Hassan Mohamed , Schott-Ohly Patricia , Friesen Nadira , Nicoletti Ferdinando , Trepicchio William L. , Gleichmann Helga 
Published: July 2017

This laboratory has reported that multiple low doses of streptozotocin (MLD-STZ) similarly upregulate the T helper (Th)1-type proinflammatory cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-γ in islets of both the diabetes-susceptible male and the diabetes-resistant female C57BL/6 mice and that MLD-STZ downregulates the anti-inflammatory Th2-type cytokines interleukin (IL)-4 and IL-10, as well as the anti-inflammatory Th3-type cytokine-transforming growth factor (TGF)β1 in islets of male, but not female, mice. Thus, diabetes is associated with a relative preponderance of local proinflammatory cytokines. Here, we investigated the effects of MLD-STZ on the anti-inflammatory cytokine IL-11 and the transcription factors nuclear factor (NF)-κB and activator protein (AP)-1, which are involved in gene activation of proinflammatory cytokines, and on the cytosolic kinase (IKK-α) of NF-κB inhibitor (IκB). Furthermore, the effect of recombinant human (rh)IL-11 on MLD-STZ diabetes, insulitis, cytokines, IKK-α, NF-κB, and AP-1 was analyzed in islets.Interleukin-11 prevented diabetes without affecting insulitis; attenuated TNF-α and IFN-γ response; and stimulated IL-4 production and inhibited activation of IKK-α, NF-κB, and AP-1. The results demonstrated the potential of rhIL-11 in preventing MLD-STZ diabetes through enhancement of anti-inflammatory responses in islets. In this process, the transcription factors NF-κB and AP-1 might play a key role.
Evaluation of a successful aging promotion intervention program for middle-aged adults in Taiwan
Authors: Hsu Hui-Chuan , Chuang Shu-Hui , Hsu Shang-Wei , Tung Ho-Jui , Chang Shu-Ching , Lee Ming-Ming , Wang Jiun-Yi , Kuo Li-Ting , Tseng Fang-Ya , Po An-Ting 
Published: July 2017

Purpose: This study was to implement and evaluate a successful aging intervention program for middle-aged private insurance beneficiaries. Methods: The participants were recruited from the staff and middle-aged clients for the experimental and control groups of a private insurance company. The two client (experimental and control) groups were matched by comparable age groups, gender, education, and purchased insurance types. The intervention program provided for the staff and the experimental group consisted of a series of educational courses on the topics about successful aging and preparation for 4 months. In total, there were 40 staff members, in addition to the 74 members of the experimental group and 60 members of the control group participating in the study. Results: After the intervention, the rate of physical activity and exercise significantly improved for the staff and for the intervention group. There were significant improvements in behaviors associated with doing exercise and living a less sedentary lifestyle and in the utilization of health examinations, and improvements in fitness and blood pressure. Conclusion: The successful aging intervention program significantly improved awareness of successful aging, exercise behavior and fitness.
T2* Mapping Provides Information That Is Statistically Comparable to an Arthroscopic Evaluation of Acetabular Cartilage
Authors: Morgan Patrick , Nissi Mikko J. , Hughes John , Mortazavi Shabnam , Ellermann Jutta 
Published: July 2017

Objectives The purpose of this study was to validate T2* mapping as an objective, noninvasive method for the prediction of acetabular cartilage damage. Methods This is the second step in the validation of T2*. In a previous study, we established a quantitative predictive model for identifying and grading acetabular cartilage damage. In this study, the model was applied to a second cohort of 27 consecutive hips to validate the model. A clinical 3.0-T imaging protocol with T2* mapping was used. Acetabular regions of interest (ROI) were identified on magnetic resonance and graded using the previously established model. Each ROI was then graded in a blinded fashion by arthroscopy. Accurate surgical location of ROIs was facilitated with a 2-dimensional map projection of the acetabulum. A total of 459 ROIs were studied. Results When T2* mapping and arthroscopic assessment were compared, 82% of ROIs were within 1 Beck group (of a total 6 possible) and 32% of ROIs were classified identically. Disease prediction based on receiver operating characteristic curve analysis demonstrated a sensitivity of 0.713 and a specificity of 0.804. Model stability evaluation required no significant changes to the predictive model produced in the initial study. Conclusions These results validate that T2* mapping provides statistically comparable information regarding acetabular cartilage when compared to arthroscopy. In contrast to arthroscopy, T2* mapping is quantitative, noninvasive, and can be used in follow-up. Unlike research quantitative magnetic resonance protocols, T2* takes little time and does not require a contrast agent. This may facilitate its use in the clinical sphere.
Comparison of hospital length of stay in patients treated with non–vitamin K oral anticoagulants or parenteral agents plus warfarin for venous thromboembolism
Authors: Saint Catherine A , Castelli Michelle R , Crannage Andrew J , Stacy Zachary A , Hennessey Erin K 
Published: July 2017

Objectives: Existing research comparing hospital length of stay for patients treated with non–vitamin K oral anticoagulants or parenteral bridging to warfarin has been conducted primarily with the agent rivaroxaban. The objective of this study was to compare hospital length of stay between patients initiated on the non–vitamin K oral anticoagulants, apixaban or rivaroxaban, and patients initiated on parenteral anticoagulation agents plus warfarin for the treatment of venous thromboembolism. Methods: A retrospective cohort study was conducted at an 859-bed, not-for-profit, teaching hospital. Adult patients admitted for a primary diagnosis of venous thromboembolism between 1 November 2012 and 31 August 2015 and treated with apixaban or rivaroxaban or a parenteral anticoagulant plus warfarin were included in the study. Eligible patients were identified using International Classification of Diseases, Ninth Revision codes for a primary diagnosis of acute thromboses and emboli and medication administration record data. Individuals using anticoagulation therapy prior to admission, released from the emergency department, or treated with thrombectomy or fibrinolytic therapy were excluded. Results: A total of 152 patients were included in this study. Patient characteristics, including renal function, were similar between study arms. Venous thromboembolism treatment with apixaban or rivaroxaban compared to a parenteral anticoagulant plus warfarin was associated with a reduced hospital length of stay (2.63 vs 5.33 days; p < 0.05) and decreased total hospital cost adjusted to 2015 dollars (US$21,694 vs US$38,851; p = 0.013). Conclusion: These results suggest that treatment with a non–vitamin K anticoagulant may significantly reduce hospital length of stay and total hospital cost compared to a parenteral anticoagulant plus warfarin for patients admitted for venous thromboembolism.
Biomechanical Comparison of a First- and a Second-Generation All-Soft Suture Glenoid Anchor
Authors: Erickson John , Chiarappa Frank , Haskel Jonathan , Rice Justin , Hyatt Adam , Monica James , Dhawan Aman 
Published: July 2017

Background: All–soft tissue suture anchors provide advantages of decreased removal of bone and decreased glenoid volume occupied compared with traditional tap or screw-in suture anchors. Previous published data have led to biomechanical concerns with the use of first-generation all-soft suture anchors. Purpose/Hypothesis: The purpose of this study was to evaluate the load to 2-mm displacement and ultimate load to failure of a second-generation all-soft suture anchor, compared with a first-generation anchor and a traditional PEEK (polyether ether ketone) anchor. The null hypothesis was that the newer second-generation anchor will demonstrate no difference in loads to 2-mm displacement after cycling compared with first-generation all-soft suture anchors. Study Design: Controlled laboratory study. Methods: Twenty human cadaveric glenoids were utilized to create 97 total suture anchor sites, and 1 of 3 anchors were randomized and placed into each site: (1) first-generation all-soft suture anchor (Juggerknot; Biomet), (2) second-generation all-soft suture anchor (Suturefix; Smith & Nephew), and (3) a control PEEK anchor (Bioraptor; Smith & Nephew). After initial cyclic loading, load to 2 mm of displacement and ultimate load to failure were measured for each anchor. Results: After cyclic loading, the load to 2-mm displacement was significantly less in first-generation anchors compared with controls ( P < .01). However, the load to 2-mm displacement was significantly greater in second-generation anchors compared with controls ( P < .01). There was no difference in ultimate load to failure between the first- and second-generation all-soft suture anchors ( P > .05). Conclusion: The newer generation all-soft suture anchors with a theoretically more rigid construct and deployment configuration demonstrate biomechanical characteristics (specifically, with load to 2-mm displacement after cyclic loading) that are improved over first-generation all-soft suture anchors and similar to a traditional solid tap-in anchor. The configuration of these newer generation all-soft suture anchors appears to mitigate the biomechanical concerns of decreased load to failure with first-generation all–soft tissue suture anchors. Clinical Relevance: The theoretical advantages of all-soft anchors may be particularly valuable in revision surgery or in cases where multiple anchors are being placed into a small anatomic area.
An Analysis of Duplicate Presentations at the 2014 Through 2016 AOSSM and AANA Annual Meetings
Authors: Kraeutler Matthew J. , Carver Trevor J. , McCarty Eric C. 
Published: July 2017

Background: Previous studies have shown a high incidence of duplicate presentations at research conferences within different medical disciplines. Purpose: To determine the rate and analyze characteristics of duplicate presentations at the American Orthopaedic Society for Sports Medicine (AOSSM) and Arthroscopy Association of North America (AANA) Annual Meetings. Study Design: Cross-sectional study. Methods: Meeting programs for the 2014 to 2016 AOSSM and AANA Annual Meetings were searched. All podium presentation abstracts from each AOSSM meeting were cross-referenced with podium presentation abstracts from AANA meetings from all 3 years of the study period to locate all duplicate presentations. Duplicate presentations were then analyzed for changes in abstract title, author order, and addition or removal of authors. Results: A total of 192 and 213 abstracts were accepted for podium presentations at the AOSSM and AANA Annual Meetings, respectively, during the study period. This included 65 presentations at the 2014 AOSSM Annual Meeting, 72 in 2015, and 55 in 2016. Overall, 28 AOSSM presentations (15%) were also presented at an AANA Annual Meeting, including 9 (14%) from the 2014 AOSSM meeting, 15 (21%) from the 2015 meeting, and 4 (7%) from the 2016 meeting. Of the 28 duplicate presentations, authors often altered their abstracts in several ways, including changing the abstract title (14; 50%), changing the author order (17; 61%), and adding or removing authors (10; 36%). Duplication rates were not significantly different between the years ( P = .10). Conclusion: A moderate proportion of abstracts presented at the AOSSM and AANA Annual Meetings are duplicates. Meeting committees may want to consider stricter guidelines to ensure only original work is presented at these meetings.
Targeting BCL-2 in B-cell lymphomas
Authors: Davids Matthew S. 
Published: July 2017

AbstractThe B-cell leukemia/lymphoma-2 (BCL-2) family of proteins governs the intrinsic pathway of mitochondrial apoptosis. Dysregulation of BCL-2 has long been known to be a crucial part of the pathophysiology of B-cell lymphomas; however, several early attempts to target this pathway therapeutically were unsuccessful because of toxicity, lack of efficacy, or both. Recently, a highly potent and selective oral BCL-2 antagonist, venetoclax, was approved in chronic lymphocytic leukemia, where it has proven to be highly active, even in patients with high-risk del(17p) disease. Venetoclax has also demonstrated efficacy in other B-cell non-Hodgkin lymphoma subtypes, in particular mantle cell lymphoma and follicular lymphoma. Here, I review the history of targeting BCL-2 in B-cell lymphomas, and I discuss recent data on venetoclax used as monotherapy and in combination with monoclonal antibodies, chemotherapy, and other novel agents. I also discuss how genomic and functional approaches such as BH3 profiling may allow us to prioritize novel-agent combinations for further study in clinical trials. These approaches may also help us to understand resistance mechanisms to BCL-2–selective therapy and how to overcome resistance. Finally, I provide my perspective on how to move BCL-2–directed therapies forward toward a goal of developing well-tolerated, time-limited combination regimens with curative potential for patients with B-cell lymphomas.
Phytochemical profile and gastroprotective potential of Myrcianthes pungens fruits and leaves
Authors: de Almeida Amanda Lorga , Beleza Maria Luisa Maes Lima , Campos Adriana , da Rosa Roseane Leandra , de Andrade Sérgio Faloni , Filho Valdir Cechinel , Nesello Luciane Angela Nottar 
Published: July 2017

Abstract
Background
The last decade has been marked by increasing data regarding gastroinstestinal diseases, specially gastritis and ulcer. In order to prevent or treat these diseases, many studies have demonstrated the potential of medicinal plants. The aim of this study was to evaluate the phytochemical profile and the gastroprotective activity of the methanolic extract of Myrcianthes pungens whole fruit, peel, pulp, seeds, and leaves.

Methods
The methanolic extracts were analyzed by thin layer chromatography (TLC) to detect the presence of phenolic compounds by direct comparison with an authentic sample. To evaluate the gastroprotective activity, two experimental models were used: acute ulcer model induced by ethanol/HCl and acute ulcer model induced by nonsteroidal anti-inflammatory drug (indomethacin). Animals were divided in different groups (n = 6) and pretreated orally with the methanolic extracts of M. pungens at doses of 50, 125, and 250 mg/kg, the positive control (cimetidine 100 mg/kg) and negative control (distilled water).

Results
The TLC analysis indicated the presence of the flavonoids quercetin and quercitrin in the leaves, quercetin in the peel, and catechin and epicatechin in the leaves and seeds of M. pungens. The extracts of leaves, peel, and pulp showed significant gastroprotective potential regarding the relative area of the lesion observed only in acute ulcer model induced by ethanol. The extracts of whole fruit, peel, pulp, seeds, and leaves showed significant gastroprotective potential observed in acute ulcer induced by indomethacin model.

Conclusions
The gastroprotective activity can be related with the presence of some phenolic compounds identified in phytochemical analysis.