bluuebunny/crossref_metadata_2025_split huggingface dataset:
Φωνολογική επίγνωση, βραχύχρονη μνήμη και ανάγνωση σε μαθητές σχολικής ηλικίας
Authors: Μαυρογιαννάκη Εραστή 
Published: November 2017

Στην παρούσα ερευνητική εργασία γίνεται προσπάθεια να διερευνηθεί η σχέση μεταξύ της δεξιότητας της φωνολογικής επίγνωσης και της εκμάθησης της ανάγνωσης καθώς και της σχέσης της βραχύχρονης μνήμης φωνολογικών πληροφοριών με αυτή. Η πειραματική διαδικασία πραγματοποιήθηκε σε δύο στάδια και οι συμμετέχοντες ήταν 39 μαθητές της πρώτης δημοτικού από δύο σχολεία της Αθήνας και της Πάτρας. Οι δοκιμασίες που χρησιμοποιήθηκαν και στα δύο στάδια ήταν οι ίδιες. Για τη στατιστική ανάλυση χρησιμοποιήθηκε το στατιστικό πρόγραμμα SPSS. Όσον αφορά στην αξιολόγηση της φωνολογικής επίγνωσης οι δοκιμασίες που χρησιμοποιήθηκαν ήταν η ηχητική ταξινόμηση, η επισήμανση της ομοιοκαταληξίας και η απόφαση για την ομοιότητα ή τη διαφορά των λέξεων. Η βραχύχρονη μνήμη φωνολογικών πληροφοριών αξιολογήθηκε με τις δοκιμασίες της μνήμης ακολουθιών αριθμών, της επανάληψης ψευδολέξεων και της ανάκλησης λέξεων. Τέλος, σχετικά με την ανάγνωση αξιολογήθηκαν οι δεξιότητες της ανάγνωσης συμφώνων, φωνηέντων, συλλαβών και συμπλεγμάτων διάφορων μορφών, λέξεων και ψευδολέξεων. Από τη στατιστική ανάλυση προέκυψε στατιστικώς σημαντική βελτίωσης της φωνολογικής επίγνωσης, της βραχύχρονης μνήμης φωνολογικών πληροφοριών και της ανάγνωσης στο δεύτερο στάδιο (Μάρτιος). Επίσης, η σχέση μεταξύ φωνολογικής επίγνωσης και ανάγνωσης ήταν θετική και στατιστικώς σημαντική, σε αντίθεση με τη σχέση της βραχύχρονης μνήμης φωνολογικών πληροφοριών με την ανάγνωση. Τέλος, στο πρώτο στάδιο η επίδραση τόσο της φωνολογικής επίγνωσης όσο και της βραχύχρονης μνήμης φωνολογικών πληροφοριών δεν ήταν στατιστικώς σημαντική. Αντίθετα, στο δεύτερο στάδιο παρατηρήθηκε μια στατιστικώς σημαντική επίδραση τόσο της φωνολογικής επίγνωσης όσο και της βραχύχρονης μνήμης φωνολογικών πληροφοριών στην παραπάνω δεξιότητα.
Food Addiction, High-Glycemic-Index Carbohydrates, and Obesity
Authors: Lennerz Belinda , Lennerz Jochen K 
Published: November 2017

AbstractBACKGROUNDTreatment success in obesity remains low, and recently food addiction has been delineated as an underlying etiologic factor with therapeutic relevance. Specifically, current treatment focuses on reduced food intake and increase of physical activity, whereas interventions for addiction encompass behavioral therapy, abstinence, and environmental interventions such as taxation, restrictions on advertising, and regulation of school menus.CONTENTHere, we reviewed the pertinent literature on food addiction with a specific focus on the role of high-glycemic-index carbohydrates in triggering addictive symptoms. Three lines of evidence support the concept of food addiction: (a) behavioral responses to certain foods are similar to substances of abuse; (b) food intake regulation and addiction rely on similar neurobiological circuits; (c) individuals suffering from obesity or addiction show similar neurochemical- and brain activation patterns.High-glycemic-index carbohydrates elicit a rapid shift in blood glucose and insulin levels, akin to the pharmacokinetics of addictive substances. Similar to drugs of abuse, glucose and insulin signal to the mesolimbic system to modify dopamine concentration. Sugar elicits addiction-like craving, and self-reported problem foods are rich in high-glycemic-index carbohydrates. These properties make high-glycemic-index carbohydrates plausible triggers for food addiction.SUMMARYWe argue that food addiction is a plausible etiological factor contributing to the heterogeneous condition and phenotype of obesity. In at least a subset of vulnerable individuals, high-glycemic-index carbohydrates trigger addiction-like neurochemical and behavioral responses.
Clasificación Automática del Avance de Megaproyectos de Inversión Pública en Colombia, desde un Enfoque Técnico, Organizacional y Ambiental
Authors: Gutierrez Hugo , Melgarejo Miguel 
Published: November 2017

Context: the TOE (Technical, Organizational, and Environmental) framework for the analysis of large scale projects is considered as the basis for the development of megaproject progress classification in accordance with the needs of the national planning agency in Colombia.Method: Classification of a megaproject progress is supported in the selection of several features taken from the TOE. These feature set is used to configure a database from the projects registered in the project-surveillance platform of the national planning agency in Colombia. The database is used to train two classification models. Information about 3200 projects from 2008 to 2012 was used, covering four economic sectors (Environment and sustainable development, Energy and mining, Health and social care and transportation). Debugging of the database was carried out by an analytic and quantitative approach. Model training and validation were computed with 70% and 30% of data respectively. Results: obtained models have similar performances beyond 70% in precision and agree in relevant input features.Conclusions: this work is a starting point to develop an automatic tool that can be used by the national planning agency of Colombia in the a-priori evaluation of delays in public investment Megaprojects.
Improving Metabolic Health Through Precision Dietetics in Mice
Authors: Barrington William T , Wulfridge Phillip , Wells Ann E , Rojas Carolina Mantilla , Howe Selene Y F , Perry Amie , Hua Kunjie , Pellizzon Michael A , Hansen Kasper D , Voy Brynn H , Bennett Brian J , Pomp Daniel , Feinberg Andrew P , Threadgill David W 
Published: November 2017

AbstractBarrington et al. examined the effect of four human diets (American, Mediterranean, Japanese, and Maasai/ketogenic) on metabolic health across four mouse...The incidence of diet-induced metabolic disease has soared over the last half-century, despite national efforts to improve health through universal dietary recommendations. Studies comparing dietary patterns of populations with health outcomes have historically provided the basis for healthy diet recommendations. However, evidence that population-level diet responses are reliable indicators of responses across individuals is lacking. This study investigated how genetic differences influence health responses to several popular diets in mice, which are similar to humans in genetic composition and the propensity to develop metabolic disease, but enable precise genetic and environmental control. We designed four human-comparable mouse diets that are representative of those eaten by historical human populations. Across four genetically distinct inbred mouse strains, we compared the American diet’s impact on metabolic health to three alternative diets (Mediterranean, Japanese, and Maasai/ketogenic). Furthermore, we investigated metabolomic and epigenetic alterations associated with diet response. Health effects of the diets were highly dependent on genetic background, demonstrating that individualized diet strategies improve health outcomes in mice. If similar genetic-dependent diet responses exist in humans, then a personalized, or “precision dietetics,” approach to dietary recommendations may yield better health outcomes than the traditional one-size-fits-all approach.
Cohesin Function in Cohesion, Condensation, and DNA Repair Is Regulated by Wpl1p via a Common Mechanism in Saccharomyces cerevisiae
Authors: Bloom Michelle S , Koshland Douglas , Guacci Vincent 
Published: November 2017

Abstract
Cohesin tethers DNA to mediate sister chromatid cohesion, chromosome condensation, and DNA repair. How the cell regulates cohesin to perform these distinct functions remains to be elucidated. One cohesin regulator, Wpl1p, was characterized in Saccharomyces cerevisiae as a promoter of efficient cohesion and an inhibitor of condensation. Wpl1p is also required for resistance to DNA-damaging agents. Here, we provide evidence that Wpl1p promotes the timely repair of DNA damage induced during S-phase. Previous studies have indicated that Wpl1p destabilizes cohesin’s binding to DNA by modulating the interface between the cohesin subunits Mcd1p and Smc3p. Our results suggest that Wpl1p likely modulates this interface to regulate all of cohesin’s biological functions. Furthermore, we show that Wpl1p regulates cohesion and condensation through the formation of a functional complex with another cohesin-associated factor, Pds5p. In contrast, Wpl1p regulates DNA repair independently of its interaction with Pds5p. Together, these results suggest that Wpl1p regulates distinct biological functions of cohesin by Pds5p-dependent and -independent modulation of the Smc3p/Mcd1p interface.
Análisis de 5 universidades colombianas con mayor porcentaje de investigaciones publicadas en revistas de primer cuartil según el SIR Iber 2014
Authors: Gómez Hurtado Rosa Elena , Gerena Herrera Alexander 
Published: November 2017

Se realizó un estudio en cinco universidades con mayor porcentaje de publicaciones en revistas de primer cuartil, según el ranking internacional SCImago Institutions Rankings Iberoamerica 2014 (SIR Iber 2014). Los registros procedentes del SIR Iber 2014 fueron exportados a una base de datos y mediante una hoja de cálculo en Excel se elaboraron tablas y gráficos que permitieron hacer recuentos estadísticos, análisis de frecuencias y análisis de cluster. Se hizo una revisión del tamaño de la producción, el impacto científico, la especialización temática y la colaboración entre las universidades en los ámbitos nacional e internacional.El estudio se realizó a partir de la revisión de los resultados obtenidos en el SIR Iber 2014, complementados con los datos obtenidos en las bases de datos Scopus y WoS, respecto a las primeras cinco universidades colombianas que, en ese año, publicaron más trabajos en revistas de primer cuartil (Q1). Los principales resultados muestran las universidades con mejor posición en el ranking SIR Iber 2014, de acuerdo con los criterios bibliométricos analizados: colaboración internacional, impacto, publicaciones de alta calidad, excelencia y liderazgo científico
Obesogenic Behavior and Weight-Based Stigma in Popular Children’s Movies, 2012 to 2015
Authors: Howard Janna B. , Skinner Asheley Cockrell , Ravanbakht Sophie N. , Brown Jane D. , Perrin Andrew J. , Steiner Michael J. , Perrin Eliana M. 
Published: November 2017

BACKGROUND:
Obesity-promoting content and weight-stigmatizing messages are common in child-directed television programming and advertisements, and 1 study found similar trends in G- and PG-rated movies from 2006 to 2010. Our objective was to examine the prevalence of such content in more recent popular children’s movies.

METHODS:
Raters examined 31 top-grossing G- and PG-rated movies released from 2012 to 2015. For each 10-minute segment (N = 302) and for movies as units, raters documented the presence of eating-, activity-, and weight-related content observed on-screen. To assess interrater reliability, 10 movies (32%) were coded by more than 1 rater.

RESULTS:
The result of Cohen’s κ test of agreement among 3 raters was 0.65 for binary responses (good agreement). All 31 movies included obesity-promoting content; most common were unhealthy foods (87% of movies, 42% of segments), exaggerated portion sizes (71%, 29%), screen use (68%, 38%), and sugar-sweetened beverages (61%, 24%). Weight-based stigma, such as a verbal insult about body size or weight, was observed in 84% of movies and 30% of segments.

CONCLUSIONS:
Children’s movies include much obesogenic and weight-stigmatizing content. These messages are not shown in isolated incidences; rather, they often appear on-screen multiple times throughout the entire movie. Future research should explore these trends over time, and their effects.
Klasszikus galactosaemia dietetikai kezelési lehetőségei
Authors: Kiss Erika , Balogh Lídia , Reismann Péter 
Published: November 2017

Abstract: Classical galactosemia is an inherited disorder of the carbohydrate metabolism, most often caused by the deficient activity of the enzyme galactose-1-phosphate-uridyltransferase. Classical galactosemia presents in the neonatal period with life threatening illness after galactose is introduced in the diet. Symptoms and signs include poor feeding, vomiting, and diarrhea, weight loss, jaundice, hypotension, cataracts, hepatosplenomegaly, hepatocellular insufficiency, and encephalopathy. Since 1975 the testing for galactosemia is part of the neonatal screening program in Hungary. Affected newborns are recognized in the first days of their life, and special diet is introduced immediately. The therapy of galactosemia is the lactose-free and galactose-poor diet for life. As a result of the nationwide newborn screening and the lifelong medical therapy, early treatment with galactosemia can achieve a normal life without serious complications. Orv Hetil. 2017; 158(47): 1864–1867.
A ritka betegségek ellátásának aktuális kérdései
Authors: Pogány Gábor 
Published: November 2017

Abstract: The aim was to present the actual situation of rare diseases, especially to characterize the circumstances in Hungary. The most important developments were summarized which could help the care of rare disease patients in the everyday practice. There are around 800 000 patients with rare diseases in Hungary. The lack of information leads to „invisibility” for the health and social care system (most of them without ICD code). Therefore, these patients still have a huge disadvantage even when compared to the patients of common diseases. Important national and international measures took place in the last years to decrease these disadvantages. The Hungarian Centres of Expertise were officially approved, thus several health care providers were able to get membership in the forming European Reference Networks. The rare disease specific “Lifebelt” Information Centre and Help Line was established by HUFERDIS. These steps assist the implementation of the National Rare Disease Plan, although its formal approval process has temporarily stopped because of the reorganization of the health care system. The summarized developments can contribute to define better patient directions, and thus decrease the family knocks about the maze of health, social and educational systems. The realization of Rare Disease National Strategy is needed to improve the current fragmentation of services and enable patients and health, social and educational professionals to provide and use best practice care. This will ensure that all patients with rare disease cannot only be diagnosed quickly, but also have timely access to the care and support that they need, resulting in a decreasing burden of families and society. Orv Hetil. 2017; 158(47): 1851–1856.
Rhabdomyolysis – Mikor vessük fel metabolikus myopathia lehetőségét? Esetismertetés és diagnosztikus algoritmus
Authors: Sebők Ágnes , Pál Endre , Molnár Gergő Attila , Wittmann István , Berenténé Bene Judit , Melegh Béla , Komoly Sámuel , Hidvégi Tibor , Balogh Lídia , Szabó Attila , Zsidegh Petra 
Published: November 2017

Abstract: We report the case of a 46-year-old female patient with recurrent rhabdomyolysis. In the background of her metabolic myopathy an inherited metabolic disorder of the fatty acid oxidation, very long-chain acyl-coenzyme A-dehydrogenase deficiency was diagnosed. The diagnosis was based on abnormal acyl-carnitine- and urine organic-acid profile in addition to low residual enzyme activity, and was confirmed by genetic testing. After introduction of dietotherapy metabolic crisis necessitating hospital admission has not occurred neither have fixed myopathic changes developed. We present here the differential diagnosis of rhabdomyolysis and exertional muscle complaints, with the metabolic myopathies in focus. The main features of fatty acid oxidation disorders are highlighted, acute and chronic managements of very long-chain acyl-coenzyme A-dehydrogenase deficiency are discussed. Metabolic myopathies respond well to treatment, so good quality of life can be achieved. However, especially in fatty acid oxidation disorders, a metabolic crisis may develop quickly and can be fatal, albeit rarely. Some of these disorders can be identified by newborn screening, but occasionally the symptoms may manifest only in adulthood. With the presentation of this case we would like to point out that in the differential diagnosis of recurrent rhabdomyolysis inherited metabolic disorders should be considered regardless of the patient’s age. Orv Hetil. 2017; 158(46): 1873–1882.
Development of tensile-compressive asymmetry free magnesium based composite using TiO2nanoparticles dispersion
Authors: Hassan Syed Fida , Ogunlakin Nasirudeen Olalekan , Al-Aqeeli Nasser , Nouari Saheb , Baig Mirza Murtuza Ali , Patel Faheemuddin 
Published: November 2017

Abstract
Perception of Curability Among Advanced Cancer Patients: An International Collaborative Study
Authors: Yennurajalingam Sriram , Rodrigues Luis Fernando , Shamieh Omar , Tricou Colombe , Filbet Marilène , Naing Kyaw , Ramaswamy Akhileshwaran , Perez-Cruz Pedro Emilio , Bautista Mary Jocelyn S. , Bunge Sofia , Muckaden Mary Ann , Sewram Vikash , Fakrooden Sarah , Noguera-Tejedor Antonio , Rao Shobha S. , Liu Diane , Park Minjeong , Williams Janet L. , Lu Zhanni , Cantu Hilda , Hui David , Reddy Suresh K. , Bruera Eduardo 
Published: November 2017

Abstract

Background
There are limited data on illness understanding and perception of cure among advanced cancer patients around the world. The aim of the study was to determine the frequency and factors associated with inaccurate perception of curability among advanced cancer patients receiving palliative care across the globe.

Materials and Methods
Secondary analysis of a study to understand the core concepts in end-of-life care among advanced cancer patients receiving palliative care from 11 countries across the world. Advanced cancer patients were surveyed using a Patient Illness Understanding survey and Control Preference Scale. Descriptive statistics and multicovariate logistic regression analysis were performed.

Results
Fifty-five percent (763/1,390) of patients receiving palliative care inaccurately reported that their cancer is curable. The median age was 58, 55% were female, 59% were married or had a partner, 48% were Catholic, and 35% were college educated. Sixty-eight percent perceived that the goal of therapy was “to get rid of their cancer,” and 47% perceived themselves as “seriously ill.” Multicovariate logistic regression analysis shows that accurate perception of curability was associated with female gender (odds ratio [OR] 0.73, p = .027), higher education (OR 0.37, p &lt; .0001), unemployment status (OR 0.69, p = .02), and being from France (OR 0.26, p &lt; .0001) and South Africa (OR 0.52, p = .034); inaccurate perception of curability was associated with better Karnofsky performance status (OR 1.02 per point, p = .0005), and being from Philippines (OR 15.49, p &lt; .0001), Jordan (OR 8.43, p &lt; .0001), Brazil (OR 2.17, p = .0037), and India (OR 2.47, p = .039).

Conclusion
Inaccurate perception of curability in advanced cancer patients is 55% and significantly differs by gender, education, performance status, employment status, and country of origin. Further studies are needed to develop strategies to reduce this misperception of curability in advanced cancer patients.

Implications for Practice
The findings of this study indicate that inaccurate perception of curability among advanced cancer patients is 55%. Inaccurate perception of curability significantly differs by gender, education, performance status, employment status, and country of origin. There is great need to facilitate improved patient–physician communication so as to improve health care outcomes and patient satisfaction.
Anti-Hu-Associated Autoimmune Limbic Encephalitis in a Patient with PD-1 Inhibitor-Responsive Myxoid Chondrosarcoma
Authors: Papadopoulos Kyriakos P. , Romero Rebecca S. , Gonzalez Gabriela , Dix James E. , Lowy Israel , Fury Matthew 
Published: November 2017

Abstract
Autoimmune encephalitis is an uncommon complication of immune checkpoint inhibitor therapy. This article reports a case of fatal anti-Hu-associated autoimmune limbic encephalitis presenting within 8 weeks following anti-PD1 therapy in a patient with myxoid chondrosarcoma and pre-existing anti-Hu antibodies. Although tumor reduction occurred in response to PD-1 inhibitor therapy, the patient had a rapidly progressive decline in neurologic function despite initial stabilization with immunosuppression. Considering the increasing use of immune checkpoint inhibitors for the treatment of various malignancies, an increase in the occurrence of neurologic adverse events is likely, requiring prompt intervention and enhanced pharmacovigilance in malignancies associated with onconeuronal antibodies.
Phase I Pharmacokinetic Study of Nivolumab in Korean Patients with Advanced Solid Tumors
Authors: Lee Keun-Wook , Lee Dae Ho , Kang Jin Hyoung , Park Joon Oh , Kim Se Hyun , Hong Yong Sang , Kim Seung Tae , Oh Do-Youn , Bang Yung-Jue 
Published: November 2017

Abstract

Lessons Learned
This pharmacokinetic study of nivolumab showed that there is little ethnic difference in the handling of nivolumab. Nivolumab was well tolerated in Korean patients.

Background
This phase I study of nivolumab, an anti-programmed cell death-1 (anti-PD-1) monoclonal antibody, investigated the pharmacokinetics and safety of nivolumab in Korean patients with advanced solid tumors. Findings were compared with results from Japan and the U.S.

Materials and Methods
In this two-part study, patients received a single dose of nivolumab (1, 3, and 10 mg/kg; ONO-4538-13) and were followed up for 3 weeks. Those who met the required criteria proceeded to the second part (ONO-4538-14), and received the same dose as in part one every 2 weeks.

Results
Six patients per dose level were enrolled (n = 18). The mean elimination half-life of nivolumab among the groups ranged from 15.0 to 19.1 days. The maximum serum concentration and area under serum concentration–time curve increased almost dose-proportionally at doses from 1 to 10 mg/kg. Adverse drug reactions (ADRs; mostly grade ≤2) were reported in seven patients (38.9%). ADRs grade ≥3 occurred in one patient (5.6%; pneumonitis). Three patients (16.7%) developed ADRs related to thyroid dysfunction.

Conclusion
The pharmacokinetic parameters of nivolumab were similar among patients from Korea, Japan, and the U.S. The safety profile was consistent with findings from previous studies.