bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments
Authors: Walter T , Zhenzhen Wang C , Guillaud O , Cotte E , Pasquer A , Vinet O , Poncet G , Ponchon T , Saurin J‐C 
Published: October 2016

BackgroundDesmoid tumours represent a major complication of familial adenomatous polyposis. Our aims were to study the factors associated with the development of desmoid tumours in familial adenomatous polyposis patients, and to describe presentation and management of desmoid tumours.Methods and patientsWe reviewed all patients with familial adenomatous polyposis followed at our institution between 1965–2013, with either identified adenomatous polyposis coli gene mutation, or a personal and family history suggesting adenomatous polyposis coli‐related polyposis. Response to treatment of desmoid tumours was assessed by Response Evaluation Criteria In Solid Tumor (RECIST) criteria.ResultsA total of 180 patients with familial adenomatous polyposis were included with a median follow‐up of 19 years since diagnosis. Thirty‐one (17%) patients developed 58 desmoid tumours, a median (range) 4.7 (0.8–41.6) years after their diagnosis of familial adenomatous polyposis. The only factor significantly associated with occurrence of desmoid tumours was the type of surgery: 12 (12%) desmoid tumours in 104 patients treated by colectomy, versus 19 (25%) desmoid tumours in 76 patients treated by proctocolectomy, p  = 0.027. The localisation of desmoid tumours was: mesenteric (n  = 25), abdominal wall (n  = 30) or extra‐abdominal (n  = 3). Nineteen patients underwent 36 surgical procedures for desmoid tumours. Recurrence occurred in 26 (72%) cases and the recurrence‐free survival was 2.6 (95% confidence interval (CI), 0.2–5.9) years. Thirteen patients received 27 medical treatments over a median 14 months. Objective response was observed in four (15%) patients and the median progression‐free survival was nine (95% CI, 1.1–16.9) months.ConclusionIf confirmed, colectomy (versus proctocolectomy) should be performed in adenomatous polyposis coli‐related familial adenomatous polyposis patients to avoid desmoid tumours. We show that there is a high prevalence of post‐surgical recurrence and the low efficacy of available medical treatments for desmoid tumours.
Cross-Sectional Analysis of Alcohol Intake and Serum Antibodies to Oral Microorganisms
Authors: Merchant A.T. , Park Y.M. , Dodhia S. , Shrestha D. , Choi Y.H. , Pitiphat W. 
Published: October 2016

The objective of this study was to evaluate the relation between alcohol intake and groups of periodontal antibody titers among individuals with normal glucose tolerance (NGT), prediabetes and diabetes. This was a cross-sectional analysis of the National Health and Nutrition Examination Survey III (NHANES III) 1988–1994 data, among individuals 40 y and older with information on alcohol intake and serum immunoglobulin G (IgG) antibody data against 19 oral microorganisms. Participants were excluded if they did not have teeth, reported that they were taking insulin, or having gestational diabetes. The sample size for this analysis was 3,219. Periodontal antibodies were grouped into four clusters using cluster analysis: Orange-Red, Red-Green, Yellow- Orange, and Orange-Blue. Cluster scores were computed for each individual by summing z-scores of standardized log-transformed IgG titers of antibodies against periodontal microorganisms making up each respective cluster. Each cluster score was modeled as an outcome. Alcohol consumption was assessed in g/day using self-reported number of days of drinking in the past 12 mo and the average number of drinks consumed per day on days when they drank. Overall, alcohol intake was positively associated with periodontal antibodies of the Orange-Red cluster (P. melaninogenica, P. intermedia, P. nigrescens, and P. gingivalis), and inversely associated with the Yellow-Orange cluster (S. intermedius, S. oralis, S. mutans, F. nucleatum, P. micra, C. ochracea) after multivariable adjustment. The association between alcohol intake and the Orange-Red cluster was strongest among individuals with diabetes; this relation was seen among individuals with and without periodontal damage. The Orange-Red cluster was positively associated with periodontal damage among individuals with diabetes. Alcohol intake was not associated with any antibody cluster among individuals with NGT or prediabetes. The effect of alcohol intake on periodontal disease may be greater among individuals with diabetes but this finding needs to be confirmed in prospective studies. Knowledge Transfer Statement: The results of this study can be used by clinicians when treating patients with periodontal disease and diabetes.
MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma
Authors: Qiang Ya-Wei , Ye Shiqiao , Chen Yu , Buros Amy F. , Edmonson Ricky , van Rhee Frits , Barlogie Bart , Epstein Joshua , Morgan Gareth J. , Davies Faith E. 
Published: October 2016

Key Points
High expression of MAF protein in myeloma due to t(14;16) translocation confers innate resistance to PIs. PIs prevent GSK3-mediated degradation of MAF protein, which further augments the resistance to PIs in t(14:16) myeloma.
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression
Authors: Tarafdar Anuradha , Hopcroft Lisa E. M. , Gallipoli Paolo , Pellicano Francesca , Cassels Jennifer , Hair Alan , Korfi Koorosh , Jørgensen Heather G. , Vetrie David , Holyoake Tessa L. , Michie Alison M. 
Published: October 2016

Key PointsMHC-II and its master regulator CIITA are downregulated in CML stem/progenitor cells in a BCR-ABL kinase–independent manner. JAK1/2 inhibition increased MHC-II expression, suggesting elevation of CML immunogenicity may provide a way to reduce CML persistence.
Noninvasive ventilation during the weaning process in chronically critically ill patients
Authors: Sancho Jesus , Servera Emilio , Jara-Palomares Luis , Barrot Emilia , Sanchez-Oro-Gómez Raquel , Gómez de Terreros F. Javier , Martín-Vicente M. Jesús , Utrabo Isabel , Núñez M. Belen , Binimelis Alicia , Sala Ernest , Zamora Enrique , Segrelles Gonzalo , Ortega-Gonzalez Angel , Masa Fernando 
Published: October 2016

Chronically critically ill patients often undergo prolonged mechanical ventilation. The role of noninvasive ventilation (NIV) during weaning of these patients remains unclear. The aim of this study was to determine the value of NIV and whether a parameter can predict the need for NIV in chronically critically ill patients during the weaning process.We conducted a prospective study that included chronically critically ill patients admitted to Spanish respiratory care units. The weaning method used consisted of progressive periods of spontaneous breathing trials. Patients were transferred to NIV when it proved impossible to increase the duration of spontaneous breathing trials beyond 18 h.231 chronically critically ill patients were included in the study. 198 (85.71%) patients achieved weaning success (mean weaning time 25.45±16.71 days), of whom 40 (21.4%) needed NIV during the weaning process. The variable which predicted the need for NIV was arterial carbon dioxide tension at respiratory care unit admission (OR 1.08 (95% CI 1.01–1.15), p=0.013), with a cut-off point of 45.5 mmHg (sensitivity 0.76, specificity 0.67, positive predictive value 0.76, negative predictive value 0.97).NIV is a useful tool during weaning in chronically critically ill patients. Hypercapnia despite mechanical ventilation at respiratory care unit admission is the main predictor of the need for NIV during weaning.
Serum 1,25-Dihydroxyvitamin D as a Biomarker of the Absence of Hypercalciuria in Postsurgical Hypoparathyroidism
Authors: García-Pascual Luis , Barahona María José , Perea Verónica , Simó Rafael 
Published: November 2016

Abstract

Context:
Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment that can lead to renal complications. The collection of 24-hour urine to detect hypercalciuria is often considered unreliable.

Objective:
The purpose of this study was to find useful predictive biomarkers of hypercalciuria in patients with permanent postsurgical hypoparathyroidism receiving treatment with oral calcium and calcitriol supplements.

Design and Setting:
The investigation was designed as a prospective cross-sectional study. An outpatient hospital clinic served as the study setting.

Patients:
Fifty-four consecutive observations were made of 34 stable outpatients with postsurgical hypoparathyroidism taking oral calcium and calcitriol supplements, and 17 adult controls without hypoparathyroidism.

Intervention:
There were no interventions.

Main Outcome Measure:
Hypercalciuria was defined as 24-hour urine calcium &gt;300 mg.

Results:
Patients without hypercalciuria (n = 21) vs those with hypercalciuria (n = 33) had lower levels of serum 1,25-dihydroxyvitamin D (33.5 ± 11.9 pg/mL vs 45.8 ± 9.5 pg/mL; P &lt; 0.001), similar albumin-corrected serum calcium (8.3 ± 0.5 vs 8.6 ± 0.5 mg/dL; P = nonsignificant), and serum parathyroid hormone (12.5 ± 5.7 vs 10.7 ± 6.8 pg/mL; P = nonsignificant). Multiple linear regression analysis showed an independent relationship between 1,25-dihydroxyvitamin D and urinary calcium excretion (B = 6.2 ± 1.423; P &lt; 0.001). A cutoff value of 33.5 pg/mL for serum 1,25-dihydroxyvitamin D to predict the absence of hypercalciuria had 100% sensitivity and 63.6% specificity, and the area under the receiver operating characteristic curve was 0.797. No patients with serum 1,25-dihydroxyvitamin D levels of &lt;33.5 pg/mL presented with hypercalciuria, regardless of the level of albumin-corrected serum calcium.

Conclusions:
Routine measurement of serum 1,25-dihydroxyvitamin D may be useful as a biomarker to predict the absence of hypercalciuria in patients with permanent postsurgical hypoparathyroidism who are receiving treatment with oral calcium and calcitriol supplements.
Temperature and evaporative water loss of leaf-sitting frogs: the role of reflection spectra
Authors: Herrerías-Azcué Francisco , Blount Chris , Dickinson Mark 
Published: October 2016

ABSTRACT
The near infrared reflection peak in some frogs has been speculated to be either for enhancing crypticity, or to help them with thermoregulation. The theoretical background for the thermoregulatory processes has been established before, but little consideration has been given to the contribution from the frogs' reflection spectra differences. In this investigation, the reflection spectra from a range of different species of frogs were taken and combined with precise surface area measurements of frogs and an approximation to the mass transfer coefficient of agar frog models. These were then used to simulate the temperature and water evaporation in anurans with and without the near infrared reflective peak. We have shown that the presence of the near infrared reflection peak can contribute significantly to the temperature and evaporative water loss of a frog. The significance of the steady-state temperature differences between frogs with and without the near infrared reflection peak is discussed in a realistic and an extreme scenario. Temperature differences of up to 3.2°C were found, and the rehydration period was increased by up to 16.7%, although this does not reduce the number of rehydration events between dawn and dusk.
DRH1, a p68-related RNA helicase gene, is required for chromosome breakage in Tetrahymena
Authors: McDaniel Stephen L. , Zweifel Erica , Harris Peter K. W. , Yao Meng-Chao , Cole Eric S. , Chalker Douglas L. 
Published: October 2016

ABSTRACT
The p68 DEAD box helicases comprise a widely conserved protein family involved in a large range of biological processes including transcription, splicing and translation. The genome of the ciliate Tetrahymena thermophile encodes two p68-like helicases, Drh1p and Lia2p. We show that DRH1 is essential for growth and completion of development. In growing cells, Drh1p is excluded from the nucleus and accumulates near cortical basal bodies. In contrast, during sexual reproduction, this protein localizes to meiotic micronuclei, initially in punctate foci in regions where centromeres and telomeres are known to reside and later in post-zygotic differentiating somatic macronuclei. Differentiation of the macronuclear genome involves extensive DNA rearrangements including fragmentation of the five pairs of germline-derived chromosomes into 180 chromosomal sub-fragments that are stabilized by de novo telomere deletion. In addition, thousands of internal eliminated sequences (IESs) are excised from loci dispersed throughout the genome. Strains with DRH1 deleted from the germline nuclei, which do not express the protein during post-zygotic development, fail to fragment the developing macronuclear chromosomes. IES excision still occurs in the absence of DRH1 zygotic expression; thus, Drh1p is the first protein found to be specifically required for chromosome breakage but not DNA elimination.
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR
Authors: Liemburg-Apers Dania C. , Wagenaars Jori A. L. , Smeitink Jan A. M. , Willems Peter H. G. M. , Koopman Werner J. H. 
Published: October 2016

ABSTRACT
Mitochondria play a central role in cellular energy production, and their dysfunction can trigger a compensatory increase in glycolytic flux to sustain cellular ATP levels. Here, we studied the mechanism of this homeostatic phenomenon in C2C12 myoblasts. Acute (30 min) mitoenergetic dysfunction induced by the mitochondrial inhibitors piericidin A and antimycin A stimulated Glut1-mediated glucose uptake without altering Glut1 (also known as SLC2A1) mRNA or plasma membrane levels. The serine/threonine liver kinase B1 (LKB1; also known as STK11) and AMP-activated protein kinase (AMPK) played a central role in this stimulation. In contrast, ataxia-telangiectasia mutated (ATM; a potential AMPK kinase) and hydroethidium (HEt)-oxidizing reactive oxygen species (ROS; increased in piericidin-A- and antimycin-A-treated cells) appeared not to be involved in the stimulation of glucose uptake. Treatment with mitochondrial inhibitors increased NAD+ and NADH levels (associated with a lower NAD+:NADH ratio) but did not affect the level of Glut1 acetylation. Stimulation of glucose uptake was greatly reduced by chemical inhibition of Sirt2 or mTOR–RAPTOR. We propose that mitochondrial dysfunction triggers LKB1-mediated AMPK activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR–RAPTOR and Glut1-mediated glucose uptake.
Nomenclatural history of the generic name Haplocladium (Bryophyta: Leskeaceae)
Authors: Ochyra Ryszard , Garland Mark 
Published: November 2016

AbstractThe nomenclatural history of the moss generic name Haplocladium is discussed. Originally, this name was validly published in 1879 by Karl Müller of Halle as a subsection, Hypnum subsect. Haplocladium. It gained generic status in 1897 when the same author provided a brief diagnosis of the new genus Haplocladium. Under Art. 41.4 Haplocladium is treated as a name at a new rank published without reference to the presumably intended basionym Hypnum subsect. Haplocladium. It is shown that the authorship of Haplocladium microphyllum, which was previously attributed to "(Hedw.) Broth.", should correctly be ascribed to "(Hedw.) Müll.Hal." (in Hedwigia 36: 140. Jun 1897). The confusion associated with H. gracile is clarified and the authorship of this name is correctly attributed to "(Schimp.) Müll.Hal." (in Hedwigia 36: 140. Jun 1897).
Report of the Nomenclature Committee for Vascular Plants: 68
Authors: Applequist Wendy L. 
Published: November 2016

AbstractThe following seven generic names are recommended for conservation: Anisomeles against Epimeridi, Goodallia Benth. against Goodallia T.E. Bowdich, Leysera against Asteropterus, Limniris against Pseudo-iris, Palhinhaea against Lepidotis, Razumovskia against Razoumofskya, and Volutaria against Amberboi. The following eleven species names are recommended for conservation: Allium saxatile M. Bieb., non Pall., with a conserved type, Carex leersii F.W. Schultz, nom. cons., against C. cuprina, Cereus adscendens against C. platygonus, Chirita hamosa with a conserved type, Clethra alnifolia with a conserved type, Cuscuta campestris against C. gymnocarpa, Eucalyptus rossii with a conserved type, Hemionitis plantaginea Cav., non Sm., Orobanche foetida with a conserved type, Senecio sarracenicus with a conserved type, and Sisymbrium pumilum Stephan, non Lam. The following five species names are not recommended for conservation: Acacia multipinnata Ducke against A. multipinnata Willd., Calamus laevigatus against C. plicatus, Dianthus crassipes against D. ferrugineus, Ophrys subfusca with a conserved type (because it is believed to be unnecessary), and Paullinia thalictrifolia against P. bipinnata. The following eleven species names are recommended for rejection: Anavinga ovata, Cestrum subsessile, Myosotis collina, Rosa ferruginea, Solanum ambrosiacum, Solanum coronatum, Solanum diantherum, Solanum jubeba, Solanum multiangulatum, Solanum perianthomega, and Trichomanes adiantoides. Cupressus tortulosa is not recommended for rejection because it is believed to be an orthographic variant of C. torulosa. It is not recommended that the conserved place of publication of Lecythidaceae be changed. It is recommended that Habenaria rodriguesii Cogn. and H. rodriguezii R. González & Lizb. Hern. be treated as homonyms. It is recommended that Bonannia and Bonania, Petteria and Peteria, and Ceropegia oculata and C. occulta be treated as not being homonyms. It is recommended that Agave gustaviana be treated as validly published. It is recommended that "Alonsoa intermedia G. Lodd.", "Caladium lividum G. Lodd.", "Cerbera laurifolia G. Lodd.", "Dichorisandra picta G. Lodd.", "Govenia Lindl. ex G. Lodd.", "Govenia superba G. Lodd.", "Hedychium flavescens G. Lodd.", and "Maxillaria galeata Lindl. ex G. Lodd." be treated as not validly published. After two ballots, no vote of at least 11 either for or against has been obtained for proposals to reject Dianthus hungaricus or to conserve Salsola with a conserved type, Tweedia with a conserved type, Calandrinia grandiflora against C. glauca, Cliffortia filicaulis with a conserved type, Leucostegia immersa against Davallia truncata, Maackia hupehensis against M. chinensis, or Tamarix ramosissima against T. pentandra, or for a request to treat Hoppea Willd. and Hoppia Nees as homonyms.
Origin of the Rapa endemic genus Apostates: Revisiting major disjunctions and evolutionary conservatism in the Bahia alliance (Compositae: Bahieae)
Authors: Baldwin Bruce G. , Wood Kenneth R. 
Published: November 2016

AbstractMolecular phylogenetic analyses of nuclear and chloroplast DNA sequences indicate that the rediscovered Apostates, known only from Rapa in the Austral Islands of southeastern Polynesia, represents an example of extreme long‐distance dispersal (>6500 km) from southwestern North America and one of at least four disjunctions of comparable magnitude in the primarily New World Bahia alliance (tribe Bahieae). Each of the disjunctions appears to have resulted from north‐to‐south dispersal since the mid‐Miocene; three are associated with such marked morphological and ecological change that some of the southern taxa (including Apostates) have been treated in distinct genera of uncertain relationship. Phyllotaxy within the Bahia alliance, however, evidently has been even more conservative evolutionarily than reflected by previous taxonomies, with alternate‐leaved and opposite‐leaved clades in Bahia sensu Ellison each encompassing representatives of other genera that share the same leaf arrangements. A revised taxonomic treatment of the Bahia alliance is proposed to recognize morphologically distinctive, monophyletic genera, including the critically endangered Apostates.
Three twenty-first-century disaster films, the ideology of science and the future of democratic debate
Authors: Maeseele Pieter , Van Der Steen Laurens 
Published: November 2016

Abstract
While news media representations of science and technology have received ample attention in academic research, there is a lack of comparable research into disaster films. Drawing on an in-depth qualitative content analysis, this article aims to explore the representation of science in three recent disaster films: The Day After Tomorrow (Emmerich, 2004), Contagion (Soderbergh, 2011) and Rise of the Planet of the Apes (Wyatt, 2011). We find these films’ representation of science contributing to a reification of science and the promotion of the ‘ideology of science’. We conclude by discussing how this representation potentially shapes the context in which late modern risks are approached in social and political debates, and to what extent this might contribute to facilitating or impeding democratic debate and citizenship.
Citizenship and the economic crisis in Europe: An introduction
Authors: Hoskins Bryony , Kerr David , Liu Liyuan 
Published: November 2016

Abstract
This article analyses the changing nature of Active and Participatory Citizenship in Europe during the period of the financial crisis from 2008–2015 and introduces the special issue which has a focus on this topic. This article and the accompanying special issue shed light on the current critical situation in Europe, how we got here and provides critical insights on where we may be headed. The findings of the research show that during the period of the economic crisis the European Union (EU) was seen to take a leadership role championing austerity and neoliberal economic policies whilst many of its citizens suffered and began to lose trust in the EU, its institutions and leaders. National politicians often successfully shifted blame to the EU for domestic policies that made citizens and public services suffer in the name of austerity for recovery. At the same time, Active and Participatory Citizenship policies received major cuts to funding, as part of the austerity drive, and were no longer considered a policy priority at both the European and the national level as concerns about mounting unemployment and a skills crisis took over. In addition, there was a general policy shift from cosmopolitan European Citizenship to a more nationalistic and, reactive citizenship driven by responses to pressing social issues such as extremism, radicalisation, migration and violence. The article concludes that in order to maintain the European project the Active and Participatory agenda needs to urgently be restored to give people a sense of belonging and ownership of Europe.
Salud y Anarquía desde Dowlais: The translocal experience of Spanish anarchists in South Wales, 1900–15
Authors: Yeoman James Michael 
Published: November 2016

Abstract
In the early twentieth century a group of Spanish anarchists settled in the town of Dowlais, South Wales, as part of a wider migration to the area prompted by the town’s ironworks. Over the following fifteen years this community kept in constant contact with their comrades in Spain through the networks sustained by the anarchist press. Examination of these records reveals the dislocation experienced by these migrants, and their efforts to retain their identity and standing within the movement they had left behind. This study highlights the benefits of a translocal approach towards anarchist internationalism, which focuses on the experience of ordinary members of the movement and their struggles to overcome the challenges presented by international movement.