bluuebunny/crossref_metadata_2025_split huggingface dataset:
Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus
Authors: Keum Youngshin , Caramori Maria Luiza , Cherney David Z. , Crandall Jill P. , de Boer Ian H. , Lingvay Ildiko , McGill Janet B. , Polsky Sarit , Pop-Busui Rodica , Rossing Peter , Sigal Ronald J. , Mauer Michael , Doria Alessandro 
Published: October 2024

Key Points

Severely increased urinary albumin excretion rate is an effective criterion to select persons with type 1 diabetes at high risk of GFR decline for enrollment in clinical trials.A history of rapid GFR decline is less effective but can be used to extend clinical trials to person with normoalbuminuric diabetic kidney disease.These findings have immediate implications for the design of clinical trials of novel renoprotective interventions in type 1 diabetes.

Background
The optimal criteria to select individuals with type 1 diabetes mellitus and albuminuric or normoalbuminuric diabetic kidney disease, who are at risk of rapid kidney function decline, for clinical trials are unclear.

Methods
This study analyzed data from the Preventing Early Renal Loss in Diabetes clinical trial, which investigated whether allopurinol slowed kidney function decline in persons with type 1 diabetes mellitus and early-to-moderate diabetic kidney disease. Rates of iohexol GFR (iGFR) and eGFR decline during the 3-year study were compared by linear mixed effect regression between participants enrolled based on a history of moderately or severely increased albuminuria (n=394) and those enrolled based on a recent history of rapid kidney function decline (≥3 ml/min per 1.73 m2 per year) in the absence of a history of albuminuria (n=124). The association between baseline albuminuria and iGFR/eGFR decline during the trial was also evaluated.

Results
Rates of eGFR decline during the trial were higher in participants with a history of albuminuria than in those with a history of rapid kidney function decline (−3.56 [95% confidence intervals (CIs), −3.17 to −3.95] versus −2.35 [95% CI, −1.86 to −2.84] ml/min per 1.73 m2 per year, P = 0.001). The results were similar for iGFR decline, although the difference was not significant (P = 0.07). Within the history of albuminuria group, the rate of eGFR decline was −5.30 (95% CI, −4.52 to −6.08) ml/min per 1.73 m2 per year in participants with severely increased albuminuria as compared with −2.97 (95% CI, 2.44 to −3.50) and −2.32 (95% CI, −1.61 to −3.03) ml/min per 1.73 m2 per year in those with moderately increased or normal/mildly increased albuminuria at baseline (P < 0.001).

Conclusions
Severely increased albuminuria at screening is a powerful criterion for selecting persons with type 1 diabetes mellitus at high risk of kidney function decline. A history of rapid eGFR decline without a history of albuminuria is less effective for this purpose, but it can still identify individuals with type 1 diabetes mellitus who will lose kidney function more rapidly than expected from physiological aging.

Clinical Trial registry name and registration number:

NCT02017171.
Perlindungan Hukum Terhadap Pekerja Toko Karpet di Desa Adat Seminyak (Studi Kasus di Crown Carpets)
Authors: Laning Marthen Lazarus , Dewi Anak Agung Sagung Laksmi , Suryani Luh Putu 
Published: October 2024

Legal protection and liability are important parts of employment. The Indonesian government creates jobs with legal protection for workers based on Pancasila and the 1945 Constitution. The omnibus law version of the Manpower Law explains the protection of workers in realizing welfare. The case study is located at Crown Carpets in Seminyak Traditional Village, Bali. Empirical legal research method with a focus on collecting data directly from the field through observation and interviews. The main source of data comes from employees at Crown Carpets and the owner of the company provides information about the protection and legal liability in the carpet shop. Secondary data includes relevant primary and secondary legal materials. The data analysis technique used is descriptive technique. The results of the interview obtained that the Crown Carpets company's responsibility for its workers only provides compensation based on the employment relationship, without providing adequate protection in accordance with applicable labor regulations. The owner of Crown Carpets revealed that the company only has verbal agreements with its workers, which do not provide definite guarantees related to work safety and financial protection in the case of serious work accidents in the form of insurance.
Bem-estar psicológico e covid-19: impactos psicológicos da quarentena na população brasileira
Authors: Malvezzi Mariana , Figueiredo Cléber da Costa , Santana Flavia Feitosa 
Published: October 2024

A Covid-19 trouxe transformações e impactos sociais, entre eles, efeitos psicológicos. Considerando o conceito de Bem-estar Psicológico (BEP) de Ryff (1995), este trabalho apoiou-se em uma visão abrangente da saúde – não a ausência de enfermidade, mas o bem-estar físico, mental, social e capacidade de enfrentar desafios a partir de seis dimensões: autoaceitação; relações positivas com os demais; autonomia; domínio do ambiente; propósito de vida; crescimento pessoal. O objetivo geral é verificar o BEP da população brasileira em quarentena; o secundário, averiguar diferenças no BEP nestes estratos: gênero, escolaridade, renda e faixa etária. Fez-se uma pesquisa quantitativa com a escala de Ryff (1995) a partir de amostragem estratificada proporcional à quantidade de óbitos divulgada pelo Governo em 3 de maio de 2020. A coleta de dados deu-se de 4 a 10 de maio do mesmo ano. Verificou-se menor BEP para baixa escolaridade e renda e maior BEP para idosos.
Bacterial Adhesion and In Situ Biodegradation of Preheated Resin Composite Used as a Luting Agent for Indirect Restorations
Authors: Bezerra ALCA , Gonçalves GGA , Alves LC , Stamfor TCM , De Brito OFF , Monteiro GQdeM 
Published: October 2024

SUMMARY

Objective:
To evaluate surface roughness and bacterial adhesion after in situ biodegradation of the cementation interface of indirect restorations cemented with preheated resin composite.

Methods and Materials:
Resin composite blocks (Z250XT/3M ESPE) were cemented to bovine enamel (7 × 2.5 × 2 mm) using preheated microhybrid resin composites: (1) Filtek Z100 (3M ESPE) (Z100); (2) Gradia Direct X (GC America) (GDX); and (3) Light-cured resin cement RelyX Veneer (3M ESPE) (RXV) (n=21). The resin composites were preheated on a heating device (HotSet, Technolife) at 69°C for 30 minutes. Disk-shaped specimens (7 × 1.5 mm) were made for biodegradation analysis with the luting agents (n=25). The in situ phase consisted of 20 volunteers’ using an intraoral palatal device for 7 days. Each device had six cylindrical wells for the blocks and the disk-shaped specimens. Biodegradation was evaluated through surface roughness (Ra), scanning electron microscopy (SEM) micromorphological analysis, and colony-forming unit (CFU) count. The film thickness of the luting agents was also measured under stereomicroscopy.

Results:
Increased surface roughness was observed after the cariogenic challenge without differences between the luting agents. Higher variation and surface flaws suggestive of particulate detachment were observed for Z100. No differences were observed in CFU counts.

Conclusions:
All materials underwent surface biodegradation, and the surface roughness of the resin cements was similar to or lower than that of the preheated resin composites. The resin composites’ film thickness was thicker than that of the resin cement. Clinicians should be aware of these factors when choosing the use of preheated resin composite since it can lead to reduced longevity of the cementation interface and, therefore, restorations.
Is It Possible for Single-shade Composites to Mimic the Color, Lightness, Chroma, and Hue of Other Single-shade Composites? An In Vitro Study
Authors: Buldur M , Ayan G 
Published: October 2024

SUMMARY

Objectives:
This study aimed to assess color matching post-repair using the same or different single-shade composites of three distinct composite resin materials (Omnichroma-OM, ZenChroma-ZC, and Charisma Topaz One-CTO) following aging in coffee solution and distilled water. Evaluation focused on color change parameters (∆E00, ∆L00, ∆C00, and ∆H00).

Methods and Materials:
Specimens were prepared in disk shape with a diameter of 8 mm and a height of 2 mm (n=180). Half of each composite group was immersed in distilled water, while the other half was immersed in coffee solution for 12 days each (n=90). After aging, cylindrical cavities with a diameter of 4 mm and a depth of 1 mm were prepared at the center of the specimens. The cavities were repaired with both themselves and other composite resins (n=10). Color measurements of the specimens were performed using VITA Easyshade 5 (VITA Zahnfabrik, Bad Säckingen, Germany) at the following time points: baseline (T0), after aging (12 days) (T1), immediately after repair (T2), one day after repair (T3), one week after repair (T4), and one month after repair (T5).

Results:
Statistically significant differences were found in the mean ΔE00 measurements among the study groups at all time points for each of the three composite resins (p&lt;0.05). Similarly, statistically significant differences were found in the mean ΔE00 measurements over time for each of the three composite resins in each study group (p&lt;0.05). The baseline measurements of materials repaired with themselves in the distilled water groups and the final measurements of materials repaired with themselves in the coffee groups were found to be within acceptable ∆E00limits. At the end of the study, only CTO repaired with OM showed acceptable color matching with different composites in both coffee and distilled water groups.

Conclusions:
Acceptable color matching was achieved when using the same material for repair in specimens aged in distilled water and coffee. However, variations in matching were observed when different materials were used for repair, indicating the need for ongoing monitoring. Contributions of ΔL00, ΔC00, and ΔH00 values to color differences vary depending on the resins and repair process and change over time.
Important Practical Conditions for Getting the High-Quality Foam Concretes
Authors: Morgun L. V. 
Published: October 2024

Introduction. The most important reasons justifying the relevance of the research on the practical methods of reducing the consumption of materials in construction industry have been distinguished. The priorities of the Russian Federation referring to the foam concrete technology have been outlined. The level of reliability of the Internet resources describing properties of the dispersedly reinforced foam concretes has been briefly evaluated. The aim of the study is to establish the relationships between the individual properties of fiber, its quantity to the mass of cement ratio, and the most important operational properties of foam concrete manufactured using a single-stage technology.Materials and methods. The types and properties of raw materials used in the experimental research, the methods for controlling the properties of mixes and hardened foam concretes have been defined.Results. The relationship between the speed of phase transition of the viscoplastic properties of the foam concrete mixes into the elastic ones and the possibility of getting a high-quality structure of the hardened foam concrete have been briefly theoretically justified. The physical reasons influencing the direction and speed of forming the raw material dispersed particle clusters in the structure of the interpore partitions of foam concrete mixes have been revealed, which are the important factors to be considered in practice to get the high-strength foam concretes. Depending on the fiber concentration in the concrete mixture composition, the specifics of the fiber physical nature influence on the speed of phase transition from viscoplastic to elastic state have been established. It has been proved that the synergetic effect of dispersed reinforcement is achieved when fiber concentration is enough to provide the significant acceleration of the phase transition. New experimental data on the influence of the individual properties of fiber on the rheological and physico-mechanical properties of D500 foam concrete has been obtained.Discussion and Conclusion. The scientific explanation of the reasons for emergence of the electret effect on the surface of synthetic fiber has been given. It has been revealed that the discovered effect is induced by the specifics of the foam concrete mixture preparation using a single-stage technology. The most important practical conditions due to be met to get the high-strength foam concrete have been determined.
PERAN INTEGRATIF PENDIDIKAN JESUIT DALAM FORMASI KEPEMIMPINAN IGNATIAN
Authors: Witono Odemus Bei 
Published: October 2024

This article explores through a qualitative approach the guiding principles and educational philosophy of Jesuit institutions, focusing on their holistic approach to personal and intellectual development. Key elements include the integration of faith and reason, the commitment to social justice, and the formation of students as conscientious and competent leaders. Central to this philosophy are the concepts of finding God in all things, the transience and immanence of God, and the dedication to the greater glory of God (AMDG) and the principle of "Magis." Keywords: Jesuit education, school, character development, faith and reason, social justice, leadership, Magis, Cura Personalis, reflective practices.
In silico prediction of physicochemical properties and drug-likeness of omega-3 fatty acids
Authors: Staneva Yordanka , Iliev Ivelin , Georgieva Svetlana , Merdjanova Albena 
Published: October 2024

Abstract
Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are recognized for their crucial roles in human health, particularly cardiovascular and cognitive function. In this study, we employed computational methodologies, leveraging the SwissADME platform and ADMETLab 3.0, to predict and cross-validate the physicochemical properties and drug-likeness of these essential fatty acids. SwissADME predictions indicated molecular weights of 278.43 g/mol for ALA, 302.45 g/mol for EPA, and 328.49 g/mol for DHA, with consensus Log Po/w values of 5.09, 5.50, and 5.72 respectively, and varying degrees of water solubility. However, predictions from ADMETLab 3.0 were almost similar: ALA with a molecular weight of 278.22 g/mol, EPA at 302.22 g/mol, and DHA at 328.24 g/mol. Significant discrepancies were observed in lipophilicity, with ADMETLab 3.0 predicting Log Po/w values of 6.461 for ALA, 6.477 for EPA, and 7.006 for DHA, higher than those from SwissADME. Additionally, water solubility predictions from ADMETLab 3.0 showed ALA with a Log S of −5.034, EPA at −4.4, and DHA at −4.638, which differed from SwissADME’s estimates. These differences reflect variations in computational approaches and algorithms. Comparison with literature data revealed general alignment in physicochemical properties, such as water solubility and lipophilicity. Furthermore, assessment of drug-likeness according to Lipinski’s rule demonstrated compliance for all three fatty acids, albeit with variations in other criteria such as Ghose, Veber, Egan, and Muegge rules. These findings underscore the reliability and applicability of computational approaches in elucidating the physicochemical properties and drug-likeness of omega-3 fatty acids, offering valuable insights for pharmaceutical research and therapeutic applications.
Approach regarding the biosafety evaluation of black and red currant pomace extracts using Allium cepa test
Authors: Grosu Luminiţa , Ferenţ Elisa , Nicuţă Daniela , Alexa Irina-Claudia 
Published: October 2024

Abstract
In the present work, biosafety evaluation of black and red currant pomace extracts was conducted using in vivo plant test system, such as Allium cepa, a sustainable method which can provide valuable information on the cytotoxic and genotoxic effect of extracts from natural sources in relation with their phytochemical composition. In this view, different aqueous and hydroethanolic extractions from black and red currant pomaces were carried out. For revealing the differences in the phytochemical profile of the studied extracts, rapid, efficient and easy-to-operate analytical techniques such as colorimetry, UV-Vis spectrometry and electrometry were used. Cytogenetic analysis of pomace extracts was achieved using Allium cepa test by scoring the mitotic index, the limit value of cytotoxicity, the phase index of mitosis and presence of chromosomal aberrations for all samples and comparing to the control (tap water). The results have shown that the cytogenetic response depends both on the type of pomaces and on the experimental extraction conditions. Compared to the control sample (22.58 %), a decrease in mitotic index for each analyzed sample was observed. As well, an increase in the cells with chromosomal aberrations was detected in onion root tips exposed to the tested extracts compared to the control (0.69 %). The lowest value of mitotic index (12.44 %) and the highest value of chromosomal aberrations (1.91 %) were recorded from the root tip cells of onion bulbs exposed to the hydroalcoholic extract obtained from red currants pomace using water/ethanol (60:40 v/v). Even if the mitotic index decreased, the limit value of cytotoxicity was higher than 50 %, level considered as a sublethal condition for the organisms. At the same time, the increase of the frequency of chromosomal aberrations is not so significant, and in correlation with the cytotoxicity limit, it does not indicate a genotoxic effect on onion cells. Following these results, it can be concluded that black and red currant pomace extracts can be safely used for possible therapeutic benefits.
The efficiency of bankruptcy proceedings and the severity of insolvency regulations in view of the implementation of the New Opportunity Policy
Authors: Banasik Przemysław , Morawska Sylwia , Prusak Błażej , Łukowski Michal , Pustułka Katarzyna 
Published: October 2024

Abstract
The article investigates the relationship between the efficiency of insolvency proceedings, as measured by their duration, and measures the severity of bankruptcy law toward debtors in 27 countries, of which 23 are EU. This objective was achieved using quantitative methods – Pearson’s correlation, pooled panel regression and Granger causality. Research shows no direct correlation between the two variables mentioned above. The increase in sanctions in bankruptcy law contributed to a decrease in the efficiency of insolvency proceedings. In addition, less stringent conditions concerning the time taken to file a bankruptcy petition translated into a shorter duration of insolvency proceedings. Therefore, supporting the New Opportunity Policy, we recommend that regulators focus on softening the legal requirements for filing a bankruptcy petition, for setting a time limit for filing and on reducing the sanctions for honest debtors, including those imposed for failure to file for bankruptcy within the period prescribed by law.
Woody Species Composition, Structure, and Diversity of Parkland and Coffee-Based Agroforestry Systems, Habro District, Eastern Ethiopia
Authors: Fantaye Yosef , Estifanos Solomon , Feyissa Samuel 
Published: October 2024

Abstract
Agroforestry practices in eastern Ethiopia are renowned for their multifunctional landscapes, contributing significantly to biodiversity conservation and enhancement. However, there is a lack of comprehensive studies on the diversity and structure of woody species within coffee-based and parkland agroforestry systems documented in a single study. This research aimed to evaluate the composition, diversity, and structure of woody species in these agroforestry systems. Conducted in the Habro district of eastern Ethiopia, the study involved randomly selecting sixteen plots for each agroforestry system. Inventory assessments of woody species were carried out using 40×40 and 20 m*20-meter plots for parkland and coffee-based systems respectively, and 5×5-meter plots for coffee shrubs. For trees with a diameter at breast height (DBH) of ≥2.5 cm, measurements of tree heights were taken. The study computed basal area, stem density, diameter, and height class distribution to characterize the structure of woody communities, and species diversity was also assessed. The findings revealed a total of 57 woody species across 31 families. Specifically, 38 woody species were recorded in parkland agroforestry, while 43 species were found in coffee-based agroforestry systems. Significant differences were observed in species diversity indices and structural parameters between the two agroforestry systems. The Shannon diversity index and richness were higher in coffee-based agroforestry compared to parkland systems. Additionally, the density and basal area of woody species were greater in coffee-based systems than in parkland agroforestry. Overall, both agroforestry systems were found to conserve a significant number of woody species, highlighting their potential to contribute to biodiversity conservation and informing future agroforestry management strategies in national programs.
Analysis of reconstructive interventions in case of failures in hiatal hernia surgery
Authors: Fedorov V. I. , Burmistrov M. V. , Sharapov T. L. , Sigal E. I. 
Published: October 2024

INTRODUCTION. The method of laparoscopic fundoplication for hiatal hernia is today the most common surgical intervention for this pathology. However, there are a significant number of complications, one of the most severe is relapse of the disease. Today, according to the world literature, there is not enough information about the causes of relapse, methods of prevention and long-term postoperative results of reconstructive operations.The OBJECTIVE was to analyze of reconstructive surgeries in patients who underwent surgery for gastroesophageal reflux disease associated with hiatal hernia.METHODS AND MATERIALS. The work was performed on the basis of data from two clinics – Oncology Department ¹ 2 of the RCOD of the Ministry of Health of the Republic of Tatarstan and Thoracic Department ¹ 2 of the RCB of the Ministry of Health of the Republic of Tatarstan. 1,661 laparoscopic interventions were performed in patients with hiatal hernia. The basis of the work is the analysis of reconstructive operations in 99 patients.RESULTS. The most common reasons for reconstructive operations were relapses of diseases in gastroesophageal reflux disease associated with a hiatal hernia: destruction and (or) migration of the fundoplication cuff – 77 (77 %) cases, recurrence of paraesophageal hiatal hernia – 10 (11 %). Reconstructive surgery in patients with relapse of hiatal hernia remains the method of choice and leads to positive results in 83 % of cases.CONCLUSION. Surgical treatment of hiatal hernia should be carried out in a specialized hospital and experienced surgeons who own both laparoscopic and open methods of treating this pathology.