bluuebunny/crossref_metadata_2025_split huggingface dataset:
S05-3: Slovenian pathway to active and healthy ageing
Authors: Knific Tjasa , Horvat Martina , Nadrag Petra , Založnik Pika 
Published: September 2024

Abstract

Purpose
Slovenia's demographic indicators are rapidly increasing (21% older persons aged 65+ in 2023). Falls in Slovenia account for 53% of all deaths due to external causes and mortality of the elderly due to falls is 2.5 times higher in Slovenia than in other EU countries. Due to aforementioned reasons Slovenia modified the national prevention program Together for health for the needs of the elderly, focusing on the health sector, patients’ homes and local communities.

Development
We modified the existing program, which generally promotes physical literacy for fall and frailty prevention. We successfully implemented national postgraduate training for health workers at the primary level of health care in the field of PA prescription and preventive treatment of the elderly (more than 700 specially trained health workers). We implemented multidisciplinary preventive treatment of those living at home, which is conducted by home nurses and is based on various geriatric syndromes, including falls.

Implementation
National Institute of Public Health Slovenia is testing a new approach, which will bring new competencies for health, social workers and NGOs in falls screening and prescriptions of PA for falls prevention, which will bring treatment closer to the patient's home and will relieve the burden on Slovenian healthcare.

Evaluation
In 2022, a total of 2117 patients were treated in PA for health workshops, 36% (n = 769) of them were over 65 years old. 58% were sufficiently physically active and results from national monitoring of aerobic capacity, strength, balance, and mobility show promising trends. Out of 13744 patients (mean age 81 years) who were home screened for falls in 2023, 49% were assessed as risky for falls.

Conclusions
The program has shown improvement in the results in the majority of participating patients in all existing treatments for active and healthy aging, in the health sector and at the patients’ home. In coming years, we will focus on long term evaluation of PA behavior in the elderly who participate in the program. We expect closer cooperation with the sports sector in providing supportive activities in local communities when the PA treatment in the health care system has ended.
S11 How to increase the reach of HEPA promotion among socially disadvantaged groups?
Authors: Murphy Niamh 
Published: September 2024

Abstract
Participation in physical activity (PA) has many benefits beyond improvements in physical health, like improved mental health, social connections, and certain skills. People from socially disadvantaged groups may benefit most from these outcomes, yet, programs that aim to increase physical activity participation among such groups often struggle with reaching and engaging adequate numbers of participants. This is unfortunate, because no matter how effective a program is for improving health and PA participation, its success and continuation is largely determined by its initial reach. In this symposium, chaired by Niamh Murphy from SETU Waterford in Ireland, we present recent insights obtained through research and practice into factors that affect the reach of physical activity interventions for various marginalized groups.
Maike Till, Karim Abu-Omar, and Heiko Ziemainz from Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, discuss findings of the community-based participatory research project “BIG”, which explored how women in difficult life situations can best be reached and encouraged to participate in physical activity. The results showed, among others, that this may require distinct approaches for women in urban and rural areas.
Jennifer Thomas, Diane Crone, Nic Bowes, Katie Thirlaway, Robert Meyers, and Kelly Mackintosh from Swansea University in Wales, UK, studied the barriers and opportunities for reaching and recruiting young people experiencing homelessness. They will present the most important factors that they identified at organizational, individual and intervention levels.
Kirsten Verkooijen, Daniëlla van Uden, Güven Alarslan, Dico de Jager and Annemarie Wagemakers from Wageningen University and Research in the Netherlands will present the most important lessons regarding program reach, based on their experience with multiple physical activity programs that are specifically designed for socially disadvantaged groups.
Finally, Seamus Nugent, a sports inclusion development officer of the Kilkenny Recreation and Sports Partnership in Ireland, will bring in a practice perspective on reaching, and providing inclusive, meaningful physical activity opportunities for children and adults living with disability in Ireland.
The contributions of direct and indirect selection to the evolution of mating preferences
Authors: Servedio Maria R 
Published: September 2024

Abstract
Many influential mathematical models of sexual selection have stressed that mating preferences evolve due to correlations that build between mating preferences and preferred display traits—that is, through indirect selection. Nevertheless, there is a perception that indirect selection should generally be overwhelmed by direct selection, for example, in the form of search costs. Recent work by Fry has used quantitative genetic models to argue that in many cases, including when there are direct benefits (a fecundity advantage to mating with the preferred male), direct and indirect selection may be of similar magnitude. Here, I use population genetic models, in which the strength of the genetic correlation is an emergent property of evolution at mating preference and display trait loci, to assess the relative contributions of direct and indirect selection to the evolution of mating preferences. For the cases of direct benefits and of indirect benefits with fixed and frequency-dependent search costs, I outline parameter values of fecundity benefits, preference strengths, and search costs for which indirect selection on female preferences can potentially predominate. I also analyze male mate choice under polygyny, showing that direct selection will always outweigh indirect selection except when there are direct benefits.
Targeted mutation of BnaMS1/BnaMS2 combined with the RUBY reporter enables an efficient two-line system for hybrid seed production in Brassica napus
Authors: Shen Xiaoxiao , Dong Qing , Zhao Xiang , Hu Limin , Bala Sukanta , Deng Songyue , Zhao Yanyan , Duan Qun , Liu Zilong , He Hanzi , Fan Chuchuan 
Published: September 2024

Abstract
The recessive genic male sterility (RGMS) method has several benefits in hybrid seed production; however, it is seldom employed in industrial hybrid seed production owing to the difficulty of producing an ample number of pure male-sterile seeds. In this study, we present an efficient methodology for developing a two-line strategy to produce hybrid seed through targeted mutation of BnaMS1 and BnaMS2 in conjunction with the RUBY reporter in Brassica napus. In this method, male-sterile lines were successfully created directly from different elite rapeseed breeding lines through CRISPR/Cas9-mediated mutagenesis and enhanced Agrobacterium-mediated transformation. To establish an efficient transgenic maintainer, three seed production technology (SPT) cassettes carrying a functional BnaMS1 gene linked to different reporters (DsRed, BnaA07.PAP2, and RUBY) were tested and compared in rapeseed. The results indicated that the PMR-based reporter possesses advantages such as phenotypic stability and ease of identification at early stages, making it an ideal tool for rapid and efficient screening. Subsequently, ideal transgenic maintainer lines with a single hemizygous copy of the SPT cassette were successfully developed in the context of Bnams1Bnams2 double mutants. The progeny from crossing the maintainer line with its male-sterile counterpart exhibited a 1:1 segregation pattern of nontransgenic male-sterile and male-fertile maintainer plants, distinguishable by seedling color. This biotechnological approach to male sterility offers promising prospects for improving the propagation of recessive genic male-sterile plants and the development of hybrid seeds in rapeseed. Furthermore, it is simple to adapt this technique to more Brassica crops.
Log Topological Recursion Through the Prism of x-y Swap
Authors: Alexandrov A , Bychkov B , Dunin-Barkowski P , Kazarian M , Shadrin S 
Published: September 2024

Abstract
We introduce a new concept of logarithmic topological recursion that provides a patch to topological recursion in the presence of logarithmic singularities and prove that this new definition satisfies the universal $x-y$ swap relation. This result provides a vast generalization and a proof of a very recent conjecture of Hock. It also uniformly explains (and conceptually rectifies) an approach to the formulas for the $n$-point functions proposed by Hock.
Mistrust and missed opportunities: BDSM practitioner experiences in healthcare
Authors: Jansen Kate L , Fried Adam L , Goetz Christianna , Kang Saleenjit 
Published: September 2024

Abstract

Background
Stigma and discrimination have been shown to be significant barriers to healthcare utilization and provider trust among sexual minority groups including BDSM and kink communities.

Aim
This exploratory study sought to better understand medical mistrust and experiences of discrimination in primary care settings and how these factors predict hiding kink-related injuries from healthcare providers.

Methods
A total of 301 individuals who self-identified as being a member of the BDSM community and engaged in BDSM-play activities completed an online survey.

Outcomes
Participants completed measures including experiences with BDSM-play-related injuries, disclosure of BDSM activity to healthcare providers, measures addressing mistrust in in healthcare providers (such as avoidance of questions about sexual health or STI testing), and experiences with discrimination in healthcare settings because of BDSM group membership (such as perceptions of being insulted or receiving poor care).

Results
Nearly, 40% of participants indicated at least one experience with discrimination in the healthcare system because they identified as a member of the kink community. Over 20% of participants indicated there were BDSM-related concerns they would have liked to discuss with their primary care provider but did not. Participants who hid injuries from their primary care provider had higher levels of medical mistrust and more experiences with medical discrimination than those who disclosed their injuries. A stepwise logistic regression determined that medical mistrust served as a significant predictor of hiding injuries from healthcare providers.

Clinical Implications
Patients who are members of the BDSM community are likely to have had negative healthcare experiences, and these experiences impact their communication with and trust in future medical encounters.

Strengths and Limitations
Strengths of the study include addressing diverse components of stigma in healthcare including both experiences with discrimination as well as perceptions of the medical field. Furthermore, potential direct consequences of past negative experiences such as hiding injuries from healthcare providers were examined. Given the likely impact of race, gender, and BDSM group membership on experiences with discrimination, a limitation includes the limited representations of BDSM participants from minoritized racial and ethnic groups. Furthermore, in addressing injuries, the survey did not differentiate intended or expected injuries obtained in BDSM play from unintentional or unwanted injuries.

Conclusion
Mistrust in the medical system impacts members of the BDSM community’s willingness to disclose injuries to their healthcare provider.
EU Methane Regulation and its impact on LNG imports
Authors: Talus Kim , Steck Gunnar , Atkin James 
Published: September 2024

Abstract
The EU Methane Regulation entered into force on 4 August 2024. It creates rules and obligations on measurement-based Monitoring, Reporting, and Verification of methane emissions of relevant activities, and on Leak Detection and Repair, and introduces limits on routine venting and flaring within the European Union (EU). In addition, and importantly for this article, it creates the first import-related requirements on methane emissions for imported fuels globally. This article will focus on the impact of the Methane Regulation on Liquified Natural Gas (LNG) imports into the EU. In this respect, the Methane Regulation creates far-reaching and difficult-to-implement obligations. The concerns for the LNG industry and imports into the EU are that (i) many of the central rules are not set out in the Methane Regulation and will be provided in the years to come and (ii) some of the key concepts and key provisions lack clarity and are open to various interpretations. As we will discuss in detail, the uncertainty created by the Methane Regulation will make contract negotiations more difficult and will negatively affect the security of gas supply within the EU.
The Interventionalist’s Perspective
Authors: Sayed Dawood 
Published: September 2024

Abstract
The field on interventional pain medicine (IPM) has evolved from medication management and steroid injections to performing more procedures of a surgical nature. As new therapies have developed geared toward minimally invasive and image guided techniques, physicians trained in IPM will play a larger role in bringing these therapies to real world practice. As the field of IPM continues to evolve, it will be essential that training and education continues to advocate for the safe and effective implementation of minimally invasive spine surgical procedures.
Vertebral Augmentation with Osteotome
Authors: Lam Christopher M. , Azeem Nomen 
Published: September 2024

Abstract
Vertebral compression fractures are common injuries sustained in the vertebral bodies of the spine and contribute up to 1 billion dollars in direct medical care costs annually. Conventional management of these fractures includes multimodal pharmacologic therapy (NSAIDs, muscle relaxants, narcotics), bracing, and surgery. Vertebral augmentation has been an emerging procedural intervention for management of these injuries whereby cement is placed in a fractured vertebral body to provide stability, resulting in decreased pain. Currently, osteotomes are mainstay instruments for safe percutaneous access to the vertebral body. This chapter reviews the evidence, procedural nuances, and criteria for vertebral augmentation with use of the osteotome.
Addressing Oneself and Patient
Authors: Bulger Jeffrey W. 
Published: September 2024

Abstract
Abstract: The initial encounter between a patient and practitioner is crucial in establishing the patient–practitioner relationship based on confidentiality and privacy. The practitioner should introduce themself accurately and determine how the patient wants to be addressed. Titles of respect are important for setting up professional boundaries and acknowledging the patient’s autonomy in providing informed consent for healthcare treatment options. The practitioner’s role is to educate patients and help them make informed decisions using the patient’s reasonable goals, values, and priorities and avoid causing harm by only providing standards of care options for the patient to consent to or refuse. It is important that practitioners and students are transparent and honest about their current status and that the student never implies that they are a licensed practitioner.
Advance Directives—Planning
Authors: Bulger Jeffrey W. 
Published: September 2024

Abstract
Abstract:The Patient Self-Determination Act of 1990 mandates that all healthcare institutions receiving Medicaid or Medicare payments must inform patients of their legal rights to make decisions about their healthcare, periodically inquire about advanced directives, document patients’ healthcare wishes, and provide educational programs on patient self-determination. An advance directive (living will) and durable power of attorney for healthcare allow patients to self-determine their treatment preferences and establish a healthcare decision-making surrogate. The durable power of attorney is accompanied by professional responsibilities for both the practitioner and surrogate, with the surrogate obligated to use the patient’s reasonable goals, values, and priorities when making treatment decisions. If these are not determinable, the surrogate must maximize the patient’s best interests using the principles of beneficence (do good) and nonmaleficence (do no harm). The living will should be respected if it provides clear instructions.
The role of culture in a suicidal process
Authors: Eskin Mehmet 
Published: September 2024

Abstract
Culture plays a significant role in the suicidal process. Researchers attribute variations in suicidal behaviours across societies to divergences in manifestations of culture. However, scholarly work mostly fails to understand what culture is, and how to conceptualize and measure this over-encompassing and elusive phenomenon. This chapter first surveys the nature of suicidal behaviour and its intersocietal variation, and then discusses the concept of culture and its relevance to suicidology. It also outlines how culture might be involved in the suicidal process, as well as some methodological considerations. The chapter chooses three cultural manifestations that scientific work previously identified as representing cross-cultural variations. The three cultural manifestations are religion, individualism–collectivism, and self-construal. Then it surveys the scientific work on the relations of religion, individualism–collectivism, and self-construal with suicidal behaviour. The chapter ends with some conclusions and recommendations for future scientific work.
Ethnic aspects in pharmacological treatment of suicidality
Authors: Döring-Brandl Eva 
Published: September 2024

Abstract
Suicidal ideations, suicide attempts, and suicide are a serious risk for individuals with psychiatric disorders. Approximately 90% of suicides occur in patients with mental disorders. Therefore, suicide prevention is a key issue in psychiatric treatment. Besides psychotherapy, pharmacotherapy plays an important role and various substances are used for treatment of suicidal patients. Immigrants and members of ethnic minorities appear to be at increased risk of suicidality. Ethnic differences in tolerability and efficacy of psychiatric medication may influence treatment outcome and might often not be considered in clinical practice. This chapter reviews different types of medication used for treatment of suicidal patients, including antidepressants, mood stabilizers, antipsychotics, and benzodiazepines, and summarizes current findings on ethnic factors influencing treatment response and/or the occurrence of side effects.
Soft tissue masses
Authors: Kang Mandeep , Ward David 
Published: September 2024

Abstract
Soft tissue tumours are a large and heterogeneous group of neoplasms with numerous histological subtypes. Malignant soft tissue masses account for less than 1% of all malignant tumours but they are life-threatening and pose a diagnostic and therapeutic challenge. There is an association of soft tissue tumour development with exposure to certain chemicals, high-dose radiation, some viral infections, and specific genetic abnormalities. In most cases, the aetiology is unknown. They are classified according to various parameters including location, growth pattern, likelihood of recurrence, presence and distribution of metastatic disease, patient age, and prognosis. Patients initially may be asymptomatic during the early stages of tumour development. As the mass matures and grows, discomfort may ensue from pressure exerted upon surrounding structures. Diagnosis is generally confirmed via an accumulation of tests, including radiological analysis, tissue biopsy, and sentinel lymph node investigation. Benign soft tissue masses are common and can either be left untreated or treated by surgery alone. Malignant soft tissue masses require a multidisciplinary and multimodality approach for clinical evaluation and management. The mainstay of treatment is surgical excision or tumour debulking with adjuvant radiotherapy and/or chemotherapy.
Ear pain and hearing loss
Authors: Hawthorne Maurice 
Published: September 2024

Abstract
The pitfall for the non-ear specialist is to think that ear symptoms can only be due to ear disease—this is far from the case. Due to its complex nerve supply, pain and paraesthesia often have an origin away from the ear but symptoms are referred to the ear; consequently earache in the presence of a normal eardrum is due to a malignancy until proven otherwise. In additional to referral to the ear of symptoms from regional disease, systemic disease can also present with earache, a good example of which is Wegener’s granulomatosis and the painless deafness associated with vitamin D deficiency. While unrelenting pain with aural discharge can be a presenting symptom of life-threatening condition such as osteitis of the skull base or a malignancy of the ear, unrelenting discharge without pain can also be a sign of life-threatening disease such as cholesteatoma, tuberculosis, and tertiary syphilis. Assessment of the patient with an ear problem should include a thorough history to include symptoms of systemic and regional disease as well as auditory and neural symptoms. Examination should include the ear but also the head and neck and upper respiratory mucosal surfaces as well as looking for signs of systemic disease. Investigation should include assessment of the hearing, search for systemic conditions and local imaging of the head and neck. Treatment of hearing loss is not just confined to hearing aids but advice should be given on prevention, and the use of environmental aids or surgery considered.
Putative retina metal/metalloid-binding proteins: molecular functions, biological processes and retina disease associations
Authors: Ugarte Marta , Lawless Craig 
Published: September 2024

Abstract
The mammalian retina contains high amounts of metals/metalloid-selenium. Their dyshomeostases are associated with certain retinal diseases. We carried out this bioinformatics study to identify the relationships between putative retinal metal/selenium binding proteins, their molecular functions, and biological processes. Identification of putative mouse metal/selenium binding proteins was based on known binding motifs, domains, patterns, and profiles. Annotations were obtained from Uniprot keywords ‘metal binding’, ‘metal ion co-factors’, ‘selenium proteins’. Protein functions were estimated by associative frequency with key words in UniProt annotations. The raw data of five mouse proteomics PRIDE datasets (available to date) were downloaded and processed with Mascot against the mouse taxa of Uniprot (SwissProt/Trembl) and MaxQuant (version 1.6.10.43) for qualitative and quantitative datasets, respectively. Clinically relevant variants were evaluated using archives and aggregated information in ClinVar. The 438 proteins common to all the retina proteomics datasets were used to identify over-represented Gene Ontology categories. The putative mouse retinal metal/metalloid binding proteins identified are mainly involved in: (1) metabolic processes (enzymes), (2) homeostasis, (3) transport (vesicle mediated, transmembrane, along microtubules), (4) cellular localization, (5) regulation of signalling and exocytosis, (6) organelle organization, (7) (de)phosphorylation, and (8) complex assembly. Twenty-one proteins were identified as involved in response to light stimulus and/or visual system development. An association of metal ion binding proteins rhodopsin, photoreceptor specific nuclear receptor, calcium binding protein 4 with disease-related mutations in inherited retinal conditions was identified, where the mutations affected an area within or in close proximity to the metal binding site or domain. These findings suggest a functional role for the putative metal/metalloid binding site in retinal proteins in certain retinal disorders.