bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of Hydroxypropyl Methylcellulose in Artificial Tears for the Treatment of Dry Eye Disease
Authors: Mysen O. Martin B. , Hynnekleiv Leif , Magnø Morten S. , Vehof Jelle , Utheim Tor P. 
Published: September 2024

AbstractDry eye disease (DED) is a highly prevalent condition, resulting in reduced quality of life, lower participation in social life and impaired work efficiency. Hydroxypropyl methylcellulose (HPMC) is a cellulose‐based viscosity‐enhancing agent and is one of the most popular therapeutic ingredients in artificial tears. This review aims to evaluate the literature on the efficacy and safety of HPMC used in the treatment of DED. Literature searches were conducted in PubMed and Cochrane CENTRAL. A total of 28 clinical trials from 26 publications are included in this review, including 21 clinical intervention studies evaluating the effect of HPMC treatment over time and seven single instillation studies evaluating the short‐term physical and symptomatic effects of HPMC after drop‐instillation. The duration of clinical intervention studies ranged from 2 weeks to 5.5 months. DED severity ranged from mild to severe. Drop frequency ranged from two to up to 16 drops per day. HPMC concentration in artificial tears ranged from 0.2% to 0.5%. No major complications or adverse events were reported. Artificial tears containing HPMC were effective at improving symptoms and some signs of DED. However, combination drops with HPMC plus other therapeutic ingredients seem more effective than HPMC alone. HPMC appears to be equally effective or inferior to hyaluronic acid (HA). There is no evidence of superiority or inferiority to either carboxymethylcellulose (CMC) or polyethylene glycol 400/propylene glycol (PEG/PG). No single study explained the choice of drop frequency or HPMC concentration. More well‐designed studies are needed to determine an evidence‐based standard for HPMC treatment, including drop frequency, concentration and molecular weight for different DED severity and subgroups.
Functional anticholinergic activity of drugs classified as strong and moderate on the anticholinergic burden scale on bladder and ileum
Authors: Kagota Satomi , Futokoro Risa , Maruyama‐Fumoto Kana , Chimoto Junko , Yamada Shizuo , Shinozuka Kazumasa 
Published: September 2024

AbstractSeveral medications are commonly administered to older Japanese patients. Since some of them have not been included in previously developed scales to estimate the anticholinergic burden, we have developed a new muscarinic receptor binding‐based anticholinergic burden scale. This study aimed to investigate the functional inhibitory effects of 60 medications, classified as anticholinergic burden scales 3 and 2 by the anticholinergic burden scale, on muscarinic receptor‐mediated contractions in the bladder and ileum.The relaxation response induced by these drugs on isolated rat bladders and ileum smooth muscles constricted by carbachol was assessed using the organ bath method. All drugs inhibited smooth muscle contractile responses induced by the muscarinic receptor activation in a concentration‐dependent manner in the rat bladder and ileum. Notably, variations were observed in the relaxation responses of the drugs, and the function EC50 values were positively correlated with the binding IC50 values in the bladder and ileum.The results of this study provide functional pharmacological evidence for the muscarinic receptor binding‐based anticholinergic burden scale. Implementation of this scale may help reduce the risk of constipation and urinary retention, which are common side effects associated with anticholinergic drugs.
Doses, serum concentrations and diagnoses of Norwegian quetiapine users 2001–2019 in a therapeutic drug monitoring material
Authors: Breivik Håvard , Westin Andreas Austgulen , Frost Joachim 
Published: September 2024

AbstractOver the past decade, increasing off‐label use of quetiapine has been reported worldwide from various sources. We wanted to investigate how this is reflected in therapeutic drug monitoring (TDM) data. Requisitions for serum concentration measurements of quetiapine from a TDM service in Central Norway during 2001–2019 were obtained and analysed for age, gender, trends in quetiapine doses, serum concentrations and indicators of diagnoses. There were 19 759 requisitions from 7459 individuals. Daily doses of quetiapine decreased by 24 mg per year (95% CI: −25.61 to −21.48, p < 0.001, N = 4505). A corresponding decrease in quetiapine serum concentrations was not seen. The proportion of requisitions with diagnoses indicating reimbursable use was 13% for the whole study period. Mean daily doses were slightly higher in the reimbursable group, but declined over time in these samples, as well. To our understanding, these results signal a trend towards lower prescribed doses of quetiapine, possibly reflecting drug repurposing and/or off‐label use. The discrepancy in the decrease of doses versus serum concentrations may reflect the intake of higher doses than prescribed and/or inappropriate TDM sampling. Our findings show that TDM data have limitations when it comes to making inferences about the use of quetiapine based on serum concentrations and clinical information on the requisitions.
Impact of female directors' foreign experience on green innovation: Evidence from China
Authors: Hussain Muhammad Jameel , Gaoliang Tian , Hussain Khalil , Alhebri Adeeb , Kouki Fadoua 
Published: September 2024

AbstractThis study explores the realm of sustainability by examining the influence of female directors' foreign experience on green innovation across various industry sectors and corporate board structures. Specifically, the research focuses on the impact of female directors' foreign experience on green innovation in Chinese listed firms from 2004 to 2021. Our findings show that female directors with foreign experience have a positive and significant effect on green innovation. Further analysis indicates that this relationship is positively and significantly moderated by state‐owned enterprises, larger firms, firms operating in polluting industries, environments with low market competition, and the presence of foreign directors on the board. The robustness of our results is confirmed through the use of different econometric techniques, alternative measures of dependent and independent variables, and addressing endogeneity concerns. Overall, our study suggests that female directors with foreign experience enhance the transfer of environmental and sustainable knowledge and practices, thereby fostering green innovation within Chinese listed firms.
Directional Texture Editing for 3D Models
Authors: Liu Shengqi , Chen Zhuo , Gao Jingnan , Yan Yichao , Zhu Wenhan , Lyu Jiangjing , Yang Xiaokang 
Published: September 2024

AbstractTexture editing is a crucial task in 3D modelling that allows users to automatically manipulate the surface materials of 3D models. However, the inherent complexity of 3D models and the ambiguous text description lead to the challenge of this task. To tackle this challenge, we propose ITEM3D, a Texture Editing Model designed for automatic 3D object editing according to the text Instructions. Leveraging the diffusion models and the differentiable rendering, ITEM3D takes the rendered images as the bridge between text and 3D representation and further optimizes the disentangled texture and environment map. Previous methods adopted the absolute editing direction, namely score distillation sampling (SDS) as the optimization objective, which unfortunately results in noisy appearances and text inconsistencies. To solve the problem caused by the ambiguous text, we introduce a relative editing direction, an optimization objective defined by the noise difference between the source and target texts, to release the semantic ambiguity between the texts and images. Additionally, we gradually adjust the direction during optimization to further address the unexpected deviation in the texture domain. Qualitative and quantitative experiments show that our ITEM3D outperforms the state‐of‐the‐art methods on various 3D objects. We also perform text‐guided relighting to show explicit control over lighting. Our project page: https://shengqiliu1.github.io/ITEM3D/.
RNF122 promotes glioblastoma growth via the JAK2/STAT3/c‐Myc signaling Axis
Authors: Xiao Qingbao , Xue Kaming , Li Lin , Zhu Kai , Fu Rong , Xiong Zhiyong 
Published: September 2024

AbstractObjectiveThe E3 ubiquitin ligase is well recognized as a significant contributor to glioblastoma (GBM) progression and has promise as a prospective therapeutic target. This study explores the contribution of E3 ubiquitin ligase RNF122 in the GBM progression and the related molecular mechanisms.MethodsRNF122 expression levels were evaluated using qRT‐PCR, WB, and IHC, while functional assays besides animal experiments were used to assess RNF122's effect on GBM progression. We also tested the RNF122 impact on JAK2/STAT3/c‐Myc signaling using WB.ResultsRNF122 was upregulated in GBM and correlated to the advanced stage and poor clinical outcomes, representing an independent prognostic factor. Based on functional assays, RNF122 promotes GBM growth and cell cycle, which was validated further in subsequent analyses by JAK2/STAT3/c‐Myc pathway activation. Moreover, JAK2/STAT3 signaling pathway inhibitor WP1066 can weaken the effect of overexpression RNF122 on promoting GBM progression.ConclusionOur results revealed that RNF122 caused an aggressive phenotype to GBM and was a poor prognosticator; thus, targeting RNF122 may be effectual in GBM treatment.
Evidence of a twofold ecological trap driven by agricultural change causing a priority farmland bird population crash
Authors: Gameiro João , Marques Ana Teresa , Venâncio Luís , Valerio Francesco , Pacheco Carlos , Guedes Américo , Pereira José , Ribeiro Luís , Moreira Francisco , Beja Pedro , Arroyo Beatriz , Silva João Paulo 
Published: September 2024

AbstractExtensive farmland in Europe hosts high biodiversity levels but is threatened by land use changes associated with market and agricultural policy drivers. We show that a nationwide replacement of rainfed cereals in favor of beef production in Portugal has coincided with a nearly 80% decline in the population of a ground‐nesting raptor, the Montagu's harrier Circus pygargus, since 2002. Reduced cereal crop cover led to nesting attempts occurring mostly in fodder crops, the predominant habitat with suitable sward structure at the onset of breeding. This results in a twofold ecological trap: early hay harvesting destroys first nesting attempts, whereas late cereal harvesting destroys replacement clutches. This double phenological mismatch prevents any breeding success and likely explains the country's observed population decline of Montagu's harriers and other key farmland birds. Reforming current agroenvironmental schemes to promote practices compatible with wild population phenology is paramount to revert these changes.
Effects of ertugliflozin on uric acid and gout‐related outcomes in persons with type 2 diabetes and cardiovascular disease: Post hoc analyses from VERTIS CV
Authors: Sridhar Vikas S. , Cosentino Francesco , Dagogo‐Jack Samuel , McGuire Darren K. , Pratley Richard E. , Cater Nilo B. , Noyes Essex Margaret , Mancuso James P. , Zhao Yujie , Cherney David Z. I. 
Published: September 2024

AbstractAimTo conduct post hoc analyses of the VERTIS CV (NCT01986881) trial to explore the effects of ertugliflozin on serum uric acid (UA) and gout‐related outcomes.Materials and MethodsParticipants with type 2 diabetes and atherosclerotic cardiovascular disease were randomised (1:1:1) to placebo, ertugliflozin 5 mg or ertugliflozin 15 mg. Mean UA over time (260 weeks) was evaluated for pooled ertugliflozin versus placebo overall, and by baseline quintile of UA (≤4.3 mg/dL [≤255.8 µmol/L], >4.3–5.1 mg/dL [>255.8–303.4 µmol/L], >5.1–5.8 mg/dL [>303.4–345.0 µmol/L], >5.8–6.9 mg/dL [>345.0–410.4 µmol/L] and >6.9 mg/dL [>410.4 µmol/L]), glycated haemoglobin level, albuminuria status, estimated glomerular filtration rate and KDIGO (Kidney Disease: Improving Global Outcomes in Chronic Kidney Disease) risk category. The effect of ertugliflozin on a composite of gout onset or initiation of anti‐gout medication was assessed.ResultsThe mean UA levels at baseline were 5.67 and 5.62 mg/dL in the placebo and ertugliflozin groups, respectively. Ertugliflozin reduced UA over Weeks 6–260 compared with placebo, with least squares mean (LSM) changes (95% confidence interval [CI]) from baseline at Week 260 of 0.07 mg/dL (−0.02, 0.15) and −0.19 mg/dL (−0.25, −0.13) in the placebo and pooled ertugliflozin groups, respectively. At Week 260, placebo‐adjusted LSM change (95% CI) from baseline in UA was −0.26 mg/dL (−0.36, −0.16) with ertugliflozin. Ertugliflozin was associated with reductions in UA across baseline UA quintiles compared with placebo. The incidence of the composite of gout‐related outcomes was 84/2539 (3.3%) for placebo and 133/5091 (2.6%) for ertugliflozin (hazard ratio for the composite 0.76 [95% CI 0.580, 1.002]).ConclusionsErtugliflozin was generally associated with lowering UA overall and across subgroups compared with placebo, and numerically reduced rates of gout‐related outcome events.
How meeting the ten pedometrics challenges can deliver healthy‐soil contributions to SDG‐related ecosystem services
Authors: Bouma Johan , Reijneveld Jan Adriaan 
Published: September 2024

AbstractWhen considering ecosystem services in line with relevant Sustainable Development Goals, the proposed logical sequence of the ten pedometric challenges can form a framework defining effective contributions by the soil science discipline to the sustainability challenge facing society. Defining relatively simple, but scientifically sound, indicators and thresholds for ecosystem services can be the basis for a transparent regulatory system justifying payment for ecosystem services provided to society. The current serious lack of trust between the policy and farming arenas can and should be restored by scientists and farmers working jointly in Living Labs, aiming to become Lighthouses, to be part of Communites of Practice (CoP). A Living Lab case study is reviewed showing that much know‐how is already available to define indicators and innovative cutting‐edge methodology adds attractive new opportunities for rapid and relatively cheap characterizations. Field work remains essential and just routinely applying standard techniques fed by existing databases may lead to poor results. Research on indicator‐thresholds has a high priority. In the case study, the important soil fertility indicator was based on the current procedure of field sampling and fertilization recommendations by specialized agencies, that is already followed by 85% of farmers. This could be expanded by including indicators for other ecosystem services thereby contributing substantially to the societal sustainability debate. Soil health plays a key role when contributing to all ecosystem services. Showing this with specific examples in a Living Lab/Lighthouse and CoP context is the best way to promote the profession which is needed to justify current major funding. Not only cutting‐edge research can contribute to defining indicators and thresholds. A hundred years of research has produced many valuable insights and methodologies that can be applied as well. The: ‘better’ can be the enemy of the: ‘good’. The sustainable development challenge is highly urgent: there is no time to lose.
A high‐frequency greenhouse gas flux analysis tool: Insights from automated non‐steady‐state transparent soil chambers
Authors: Themistokleous George , Savvides Andreas M. , Philippou Katerina , Ioannides Ioannis M. , Omirou Michalis 
Published: September 2024

AbstractNon‐steady‐state chambers are widely employed for quantifying soil emissions of CO2, CH4, and N2O. Automated non‐steady‐state (a‐NSS) soil chambers, when coupled with online gas analysers, offer the ability to capture high‐frequency measurements of greenhouse gas (GHG) fluxes. While these sampling systems provide valuable insights into GHG emissions, they present post‐measurement challenges, including the management of extensive datasets, intricate flux calculations, and considerations for temporal upscaling. In this study, a computationally efficient algorithm was developed to compute instantaneous fluxes and estimate diel flux patterns using continuous, high‐resolution data obtained from an a‐NSS sampling system. Applied to a 38‐day dataset, the algorithm captured concurrent field measurements of CO2, CH4, and N2O fluxes. The automated sampling system enables the acquisition of high‐frequency data, allowing the detection of episodic gas flux events. By using shape‐constrained additive models, a median percentage deviation (bias) of −1.031 and −4.340% was achieved for CO2 and N2O fluxes, respectively. Simpson's rule allowed for efficient upscale from instantaneous to diel flux values. As a result, the proposed algorithm can rapidly and simultaneously calculate CO2, CH4, and N2O fluxes, providing both instantaneous and diel values directly from raw, high‐temporal‐resolution data. These advancements significantly contribute to the field of GHG flux measurement, enhancing both the efficiency and accuracy of calculations for a‐NSS soil chambers and deepening our understanding of GHG emissions and their temporal dynamics.
Noncompressive myelopathy in acute community‐acquired bacterial meningitis: Report of seven cases and review of literature
Authors: Drost Evelien H. G. M. , Chekrouni Nora , Brouwer Matthijs C. , van de Beek Diederik 
Published: September 2024

AbstractBackground and purposeBacterial meningitis is a severe disease with high rates of complications and unfavorable outcome. Complications involving the spinal cord are rarely reported.MethodsCases of noncompressive myelopathy were identified from a nationwide cohort study of adults with community‐acquired bacterial meningitis in the Netherlands. The American Spinal Injury Association Impairment Scale was used to classify the severity of spinal cord dysfunction. Subsequently, we reviewed the literature on noncompressive myelopathy as a complication of bacterial meningitis.ResultsNoncompressive myelopathy was reported in seven of 3047 episodes of community‐acquired bacterial meningitis (0.2%). The median age of these patients was 51 years (range = 17–77). Causative pathogens were Streptococcus pneumoniae in three, Streptococcus agalactiae in two, and Neisseria meningitidis and Haemophilus influenzae both in one. Paresis of legs (n = 6) or arms and legs (n = 1) was the presenting symptom, occurring after a median duration of 9 days after admission (range = 2–28). Spinal magnetic resonance imaging showed T2‐weighted abnormalities of the spinal cord in six of seven patients. Improvement of spinal cord function during admission was noted in four of seven patients. The literature review yielded 15 additional cases. Among patients from our cohort and the literature, there was no significant association between immunosuppressive therapy and subsequent improvement of spinal cord function (5/8 patients with immunosuppressive therapy [63%] vs. 5/14 without immunosuppressive therapy [36%], p = 0.44).ConclusionsNoncompressive myelopathy is an uncommon but severe complication of bacterial meningitis. Improvement after diagnosis is expected, but all patients had persistent neurological deficits.
Early life seizures and olfactory communication in rats
Authors: Bigelow Logan J. , Pope Emily K. , Jarvis Jack H. M. , Fiset Catherine , Le Maistre‐Matthys Carol , Benke Tim A. , Bernard Paul B. 
Published: September 2024

AbstractObjectiveEarly life seizures (ELS) are commonly associated with autism spectrum disorder (ASD); however, the exact role of ELS in the pathology is unknown. Prior studies have demonstrated social deficits, a core feature of ASD, following ELS; consequently, alterations in sensory modalities may contribute to the overall social deficits. Considering the speculated contribution of sensory deficit to social communication, we examined the developmental consequences of early postnatal kainic acid (KA)‐induced seizures on olfactory preference and neural markers in the olfactory bulb in both male and female Sprague Dawley rats.MethodsKA‐induced seizures or saline was administered. Rats were then exposed to a series of biologically relevant scents including male scent, female scent, nest scent, and phenylethylamine during the juvenile period and again during adulthood. Alterations in sensory modalities were expected to be expressed via abnormal preference for certain scents and/or production of abnormal ultrasonic vocalizations in response to scents. The olfactory bulbs were also assessed for the biologically relevant markers glial fibrillary acidic protein (GFAP) and calcium/calmodulin‐dependent protein kinase II (CAMKII).ResultsOur findings resulted in no significant differences in olfactory preference following ELS for juveniles or adults compared to controls. Similarly, there were no differences in GFAP expression or the ratio of phosphorylated CAMKII to CAMKII in either olfactory bulb. Interestingly, despite a lack of treatment differences, different scents were shown to elicit different responses in juvenile rats, yet these differences subsided in adulthood.SignificanceOverall, the results of this study suggest that olfaction does not contribute to socialization deficit following ELS within the KA model.
Evaluation of Sézary cell marker expression and cell death behaviour upon in vitro treatment by flow cytometry in Sézary syndrome patients
Authors: Melchers S. , Roemer M. , Albrecht J. D. , Assaf C. , von Gugelberg C. , Guenova E. , Klemke C.‐D. , Moritz R. K. C. , Schlaak M. , Stadler R. , Wehkamp U. , Wobser M. , Albrecht T. , Goerdt S. , Schneider S. , Nicolay J. P. 
Published: September 2024

AbstractThe diagnosis of Sézary syndrome (SS) relies on the identification of blood Sézary cells (SC) by different markers via flow cytometry. Treatment of SS is challenging since its pathogenesis is characterized by cell death resistance rather than hyperproliferation. In this study, we establish an integrated approach that considers both the expression of SC markers and sensitivity to cell death both spontaneously and upon in vitro treatment. Peripheral blood mononuclear cells were isolated from 20 SS patients and analysed for the SC markers CD7 and CD26 loss as well as CD158k and PD1 gain. The cells were then treated with different established and experimental therapies in vitro and cell death was measured. Spontaneous and therapeutically induced cell death were measured and correlated to cellular marker profiles. In the marker‐positive cells, spontaneous cell death sensitivity was reduced. Different treatments in vitro managed to specifically induce cell death in the putative CTCL cell populations. Interestingly, a repeated analysis after 3 months of treatment revealed the CTCL cell death sensitivity to be restored by therapy. We propose this novel integrated approach comprising the evaluation of SC marker expression and analysis of cell death sensitivity upon treatment that can also enable a better therapy stratification.