bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma Line HN5 by Idarubicin-ZHER2 Affibody Conjugate
Authors: Ghanemi Marzieh , Pourshohod Aminollah , Ghaffari Mohammad Ali , kheirollah Alireza , Amin Mansour , Zeinali Majid , Jamalan Mostafa 
Published: May 2017

Background:Expression of human epidermal growth factor receptor type 2 (HER2) in head and neck squamous cell carcinoma (HNSCC) cell line HN5 can be employed with great opportunities of success for specific targeting of anti-cancer chemotherapeutic agents.Objective:In the current study, HER2-specific affibody molecule, ZHER2:342 (an engineered protein with great affinity for HER2 receptors) was selected for conjugation to idarubicin (an anti-neoplastic antibiotic).Method:ZHER2:342 affibody gene with one added cysteine code at the its 5′ end was synthesized de novo and then inserted into pET302 plasmid and transferred to E. Coli BL21 hosting system. After induction of protein expression, the recombinant ZHER2 affibody molecules were purified using Ni- NTA resin and purity was analyzed through SDS-PAGE. Affinity-purified affibody molecules were conjugated to idarubicin through a heterobifunctional crosslinker, sulfosuccinimidyl 4-(Nmaleimidomethyl) cyclohexane-1-carboxylate (Sulfo-SMCC). Specific toxicity of idarubicin-ZHER2 affibody conjugate against two HER2-positive cells, HN5 and MCF-7 was assessed through MTT assay after an exposure time of 48 hours with different concentrations of conjugate.Results:Idarubicin in the non-conjugated form showed potent toxic effects against both cell lines, while HN5 cells were significantly more sensitive compared to MCF-7 cells. Dimeric ZHER2 affibody showed a mild decreasing effect on growth of both HN5 and MCF-7 cells at optimum concentration. Idarubicin-ZHER2 affibody conjugate at an optimum concentration reduced viability of HN5 cell line more efficiently compared to MCF-7 cell line.In conclusion, idarubicin-ZHER2 affibody conjugate in optimum concentrations can be used for specific targeting and killing of HN5 cells.
Purwarupa Sistem Prediksi Luas dan Hasil Panen Padi suatu Wilayah menggunakan Pengolahan Citra Digital dengan Metode Sobel dan Otsu
Authors: Putri Ardya Yunita , Sumiharto Raden 
Published: May 2017

Area and paddy crop yield prediction system of an area using image processing by Sobel Otsu’s method is one of system that utilize aerial photo data for measuring area and prediction of its crop yield. Otsu’s method is used to thresholding process and Sobel’s method is used to detect paddy field’s edges that will calculate its area. Then filtering process so that the scanning process white pixels are counted only exist in the desired region. After the amount of white pixel(s) is obtained, their amount is multiplied with the scale that obtained from calibration process and crop yield prediction (kg/m2). Detection of yellow paddy color that ready-to-harvest is successfully performed by processing the HSV color, which is then detected by thresholding HSV. At the time of testing with variety of paddy color, the detected paddy color is the paddy color ready-to-harvest, which is brownish yellow that represented by white pixels, and will be used then to predict its area and crop yield. Thereafter, accuracy calculation test resulting in different error levels in different paddy fields. Error in testing of this system are 3,1 %, 8,7%, 4,9% dan 248%. The highest error value is caused by excessive exposure of light, with the result that the green color on paddy is detected by the system as yellow and some areas are covered by trees that, thereby reducing paddy fields area calculation.
Narrating ‘finances’ after John Law: Complicity, critique, and the bonds
of obligation in Duclos and Mouhy
Authors: Abramson Julia L. 
Published: May 2017

Abstract
Attending to the peculiar significance of
finance(s) and the
financier in Old Regime France, this article
analyzes narratives that rehabilitate both, circa 1740-1755, in their
political, social and biographical contexts. Positive representations are
not thought to have been common. Yet following the Law debacle, restoration
of traditional court finance resulted in effective administrative practices,
universalizing policies and opportunities for merit, combined with money, to
drive advancement, competing with hereditary privilege. Across genres,
Charles Pinot-Duclos and Charles de Fieux, the Chevalier de Mouhy, depicted
how upstart elites enact virtue, philanthropy and patriotism through
finance. Their depictions reflected State policies and served common
interests of writers and their protectors and patrons. Yet by emphasizing
tensions in mid-century society, their texts also challenged readers to
reflect critically on relations among finance, politics, society and
indebtedness, anticipating a later focus on political economy as such. For
today's readers grappling with dilemmas of modern finance, society and
obligation, they provide provocative precedents.
Discourse ethics for debt markets
Authors: Johnson Timothy C. 
Published: May 2017

Abstract
This article develops a pragmatic theory of finance in which markets are
considered to be centres of communicative action in the face of uncertainty.
This contrasts with the conventional approach that portrays markets as
centres of strategic action in the face of scarcity. The argument follows
Habermas and entails that a financial market must address the truthfulness,
truth, and rightness of the statements made by its participants (i.e., the
prices quoted). I claim that these discursive norms have been implicit in
historical financial markets as expressed in the norms of sincerity,
reciprocity, and charity. I conclude by proposing that ‘trust’ in commerce
is a synthesis of the three discursive norms. The motivation of the article
is to address the crisis of legitimacy that the financial system is
experiencing, particularly in the United Kingdom (UK) and the United States
(US).
An introductory framework for ‘Habilito: Debt for Life’
Authors: Sturtevant Chuck 
Published: May 2017

Abstract
The documentary film Habilito: Debt for Life
provides a case study of the conflicts and tensions that arise at the point
of contact between highland migrants and Mosetenes, members of an indigenous
community in the Bolivian Amazon. It focuses particularly on a system of
debt peonage known locally as ‘habilito’. This system is used throughout the
Bolivian lowlands, and much of the rest of the Amazon basin, to secure labor
in remote areas. Timber merchants advance market goods to Mosetenes at
inflated prices, in exchange for tropical hardwood timber. When it comes
time to settle accounts, the indebted person often finds that the wood he
has cut does not meet his debt obligation, and he has to borrow more money
to return to the forest to continue logging. This permanent cycle of debt
permits actors from outside these indigenous communities to maintain control
over the extraction of wood and provides them with a free source of labor in
the exploitation of timber resources. This system is practiced especially in
remote areas where systems of patronage predominate, and where colonists
with a market-based economic logic come into contact with Amazonian
indigenous peoples who, historically, have not employed an economic logic of
saving or hoarding.
Presenting LusoLit: A lithotheque of knappable raw materials from central and southern Portugal
Authors: Pereira Telmo , Farias Anne , Paixão Eduardo 
Published: May 2017

The knowledge of where past human populations collected their raw materials to produce stone-tools is crucial to understand subjects such as their territoriality, mobility, decision-making, range of acquisition, networks and, eventually, to infer their cognitive abilities and the adaptations to new environments, landscapes and territories. Therefore, the creation of lithic reference collections (lithotheque) is of utmost importance.
In geological terms, Portugal is a highly complex and diversified region, with a plethora of igneous, sedimentary and metamorphic rocks dated from Proterozoic to present days. Such diversity might have influenced considerably the human decision-making on the choices of raw material and it might be one of the major reasons for the diversity seen throughout the diachrony of its archaeological record. Thus, sampling, cataloguing and mapping the raw material diversity in a territory with such variability allows to enrich the knowledge about it and, consequently to build stronger inferences about past human behaviour with more detail and less bias.
In order to help the archaeological and anthropological research to better understand such archaeological record and past human behaviour in this territory, we started a reference collection for this region host in the University of Algarve: the LusoLit. Though in its early stages, this collection has already several hundred chert samples from Central and Southern Portugal. In this early stage, the raw material that we start collecting was chert because it is the least ubiquitous through the landscape and, consequently, that can provide better information.
EFFECT OF SWISS BALL EXERCISE TOWARD THE BODY BALANCE TO LESS THE RISK FALL OF OLDER AT UPT SOCIAL
Authors: Syapitri Henny 
Published: May 2017

Abstract The balance of body is one of the main factor in doing fungsional activity. In every activity, the body always need control of the body balance, because basically every phisic activity right static or dinamic will take someone on unstable position with big risk to having fell. Swiss Ball exercise as support is believed on labile surface will make spine have big chance to stabling the muscle between vebra and increase the dinamic balance to restrain the repeats stability. The research object to know The Effect of Swiss Ball Exercise toward The Body Balance to Less The Risk Fall of Older at UPT Social Service of Older and Children Under Five district Binjai and Medan in Year 2016. The research type is Quasi Experiment with pre test-post test one group only design method. Population in this research all of older at UPT Social Service district Binjai as much as 172 older with number of man is 81 and woman is 91, with Purposive sampling Technique that is 15 respondences. Data collecting using observation sheet with analysis that used is univariat: respondence characteristics, the body balance of older before and after doing Swiss Ball practice, and bivariat with Paired t-Test. The research result showing the average of body balance before doing Swiss Ball as much (Mean 38,07) and after (Mean 46,33). Conclusion: there is the effect of Swiss Ball toward body balance to less the risk fall of older (p=0,000 ; p=< 0,05). Sugessted for older to practice the balance himself more steady so that not easy to have risk fall further. Influenced, and for the next researcher can research about another factor that foregrounded the risk fall of older.Keywords : Swiss Ball, Balance Exercise, Risk Fall
INCREASING OF KNOWLEDGE AND ATTITUDE OF WOMEN IN MEETING THE NUTRITION DURING PREGNANCY THROUGH HEALTH PROMOTION
Authors: Wahyudi Andri Setiya , Suarilah Ira Suarilah , Mumpuningtias Elyk Dwi , Astutik Mery Fuji 
Published: May 2017

Introduction: Pregnancy lead to changes in anatomical, physiological, and biochemical. Changes of it affect the nutritional needs of pregnancy. Knowledge and a bad attitude will affect the nutritional needs of pregnancy. This research aims to know the affect of health promotion of the knowledge and attitude of mother in fulfillment of nutrition during pregnancy in Paberasan village. Method: The quasy experiment with pretest posttest control group design. The amount of pregnant in Paberasan village were 32 people. Analysis using the Wilcoxon Signed Rank test and Mann-Whitney. Result: The result showed that, the treatment group before given health promotion the majority have enough knowledge (81,25%). After given health promotion all of respondent have good knowledge (100%). The attitude of pregnant before given health promotion the majority have enough attitude (68,75%). After given health promotion the majority have good attitude (68,75%). In the control group before given health promotion the majority have knowledge enough (75%). The control group obtained the results of the knowledge tends to remain. The attitude of pregnant before given health promotion majority has enough attitude (62,50%). The control group obtained the result of the attitude tends to remain. Mann-Whitney test results obtained significant value p=0,000 less than 0.05. Attitude test results before and after treatment in the treatment group and the control group obtained significant value p = 0.001 less than 0.05. The results showed that there is effect of health promotion of the knowledge and attitudes of mothers in fulfillment of nutrition during pregnancy. Discussion: Health workers in Paberasan village to give health promotion about the fulfillment of nutrition during pregnancy to the community to help improve the knowledge of society and help realize the achievement of fulfillment of good nutrition during pregnancy. Keyword: Promotion, health, nutrition, pregnant, knowledge, attitudes, Paberasan, Sumenep
Placebo Mechanisms of Manual Therapy: A Sheep in Wolf's Clothing?
Authors: Bialosky Joel E. , Bishop Mark D. , Penza Charles W. 
Published: May 2017

When a physical therapist provides a manual therapy (MT) intervention for a patient presenting with pain and the patient experiences a positive clinical outcome, we cannot answer as to why this occurs. Would we continue to devote valuable time and financial resources to learning and improving our skills in providing MT interventions if the related clinical outcomes were placebo responses? In this Viewpoint, the authors conceptualize placebo as an active and important mechanism of MT and argue that placebo mechanisms deserve consideration as an important component of the treatment effect. J Orthop Sports Phys Ther 2017;47(5):301–304. doi:10.2519/jospt.2017.0604
L1 Epithelioid Hemangioma
Authors: Davis Joel D. , Koppenhaver Shane 
Published: May 2017

A 24-year-old male soldier on limited-duty status was referred to physical therapy by his primary care physician for a 2-year history of insidious-onset and slowly progressive low back pain. Lumbar radiographs were noncontributory. Shortly after initiating rehabilitation, the patient underwent magnetic resonance imaging that was previously ordered by his primary care physician. Radiology identified a complex mass and cortical fracturing within the L1 vertebral body, and subsequent computed tomography imaging demonstrated mixed sclerotic and lytic foci at L1. Biopsy later confirmed an epithelioid hemangioma. J Orthop Sports Phys Ther 2017;47(5):367. doi:10.2519/jospt.2017.6689
Données LiDAR aériennes: pertinence de l'interprétation visuelle pour la foresterie
Authors: Parkan Matthew 
Published: May 2017

Airborne LiDAR data: relevance of visual interpretation for forestry
Airborne LiDAR surveys are particularly well adapted to map, study and manage large forest extents. Products derived from this technology are increasingly used by managers to establish a general diagnosis of the condition of forests. Less common is the use of these products to conduct detailed analyses on small areas; for example creating detailed reference maps like inventories or timber marking to support field operations. In this context, the use of direct visual interpretation is interesting, because it is much easier to implement than automatic algorithms and allows a quick and reliable identification of zonal (e.g. forest edge, deciduous/persistent ratio), structural (stratification) and point (e.g. tree/stem position and height) features. This article examines three important points which determine the relevance of visual interpretation: acquisition parameters, interactive representation and identification of forest characteristics. It is shown that the use of thematic color maps within interactive 3D point cloud and/or cross-sections makes it possible to establish (for all strata) detailed and accurate maps of a parcel at the individual tree scale.
Multitemporales, flugzeuggetragenes Laserscanning für die Forstwirtschaft
Authors: Hollaus Markus , Pfeifer Norbert 
Published: May 2017

Multi-temporal airborne laserscanning data for forestry applications
During the last decade airborne laserscanning (ALS) data has been established as a suitable data source for three-dimensional description of forests and for deriving forest parameters. For the study area Vorarlberg, Austria, the potential of multi-temporal ALS data (data from 2004 and 2011) was analyzed for deriving the amount of harvests in terms of area and stem volume. The data were used as well to assess the site index with the aid of the changes in top heights. The analyses have shown that harvested areas could be detected with a minimum mapping unit of 20 m2, which corresponds to harvested single trees from the dominant canopy layer. The average amount of harvested stem volume could be estimated with an overall accuracy of 96.4%. The derived changes in top heights clearly reflect the local growth conditions. For the study area Liechtenstein two ALS data sets (leaf-on and leaf-off) were used for the differentiation between coniferous and deciduous forests. Here, an overall accuracy of 92% could be achieved.
Evaluation automatischer Einzelbaumerkennung aus luftgestützten Laserscanning-Daten
Authors: Menk Julia , Dorren Luuk , Heinzel Johannes , Marty Mauro , Huber Markus 
Published: May 2017

Evaluation of automated single-tree recognition from airborne laser scanning data
In the present study, we investigated whether the detection tool FINT (Find Individual Trees) can identify single trees out of canopy height models (CHM) precisely enough to assess the protective effect of forests, even on steep slopes. For this purpose, reference trees were measured and described in twelve randomly selected sample plots in the Bündner Herrschaft and Schanfigg regions (Canton Graubünden, Switzerland). CHMs of different resolution and smoothing were generated from airborne laser scanning data for each sample plot and subsequently processed with FINT. In addition, we tested whether the use of a model that defines the minimum distance between a tree and its neighbours based on its height (MBA model) improved the quality of the results. The study showed that a finer-resolution CHM combined with stronger smoothing produced results comparable to those obtained with an unsmoothed and lower-resolution CHM. The smallest difference between the numbers of trees measured and detected was achieved with the 1-m resolution CHM, with no smoothing and no MBA model. In conclusion, FINT can provide a basis for assessing the protective effect of a forest with its existing structures, and its results – after evaluation in the field – can be directly integrated into natural hazard simulation models.
Anatomical, Histological And Metabolic Differences Between Hypodermis And Subcutaneous Adipose Tissue
Authors: Gonzaga da Cunha Marisa , Cury Rezende Flávia , Gonzaga da Cunha Ana Lucia , Machado Carlos A. , Fonseca Fernando Luiz Affonso 
Published: May 2017

The development of treatments using stem cells has drawn the attention of researchers to fat deposits given the fact they represent an almost unlimited reservoir of such cells, which can be accessed through minimally invasive techniques. However, the standardization of these studies has been made difficult because of the controversies of nomenclature regarding the many components of adipose tissue. Despite their distinct and independent structures with different metabolic responses, the terms hypodermis and subcutaneous adipose tissue are many times used as synonyms. However, the correct distinction between these two layers, the knowledge of their behavior and an uniformity of these terminologies are of utmost importance.
Thus, the purpose of this study was to make a bibliographic review on the theme, aiming to show the anatomical, histological and metabolic differences between these two tissues and standardize their nomenclature.
Factors Associated With Subjective Well-Being In Adults With Hemophilia
Authors: Holsbach Denise Rodrigues , Ivo Maria Lúcia , Pereira Leonardo Costa , Carvalho Alexandra Maria Almeida , Sá Evandro Claudino de , Albuquerque Viviane Tobias , Azevedo Isabelle Campos de , Ferreira Júnior Marcos Antonio 
Published: May 2017

Objectives: To evaluate the positively and negatively factors associated with the subjective well-being of adults with hemophilia from two associations of patients.
Methods: This study is a cross-sectional survey, carried out with convenience sampling in two patient associations. Data collection took place in November and December of 2015. The evaluation protocol consisted of the application of two instruments: Hemophilia Well-Being Index and a collection form of sociodemographic and clinical data.
Results: Fifty-three adults with hemophilia, and male, participated in the study. Their age ranged from 21 to 54 years old. It was observed a higher prevalence of participants with single marital status and third education level. The age and marital status of the participants did not influence their well-being.
Conclusion: The high level of education was positively associated with the well-being of the participants, related to the item “economic situation.”
Keywords: Hemophilia A; Hemophilia B; Adult; Subjective Well-Being Scale.
Health Education to Strengthen Breastfeeding Actions
Authors: Sousa Raul Rodrigues Cipriano , Cirino Ingred Pereira , Vera Paula Valentina de Sousa , Sousa Artemízia Francisca , Lima Luisa Helena De Oliveira , Oliveira Edina Araújo Rodrigues 
Published: May 2017

Introduction: Breast milk is, without a doubt, the food that provides all the nutrients essential for the healthy growth and development of children. Through effective breastfeeding practices, it is possible to prevent several chronic noncommunicable diseases in childhood, adolescence, and adulthood.
Objective: To investigate the relevance of using an educational strategy in breastfeeding promotion.
Methods: It was a descriptive study with uncontrolled analytical approach conducted with 36 mothers of children under 2 years of age about breastfeeding, through an educational intervention using the booklet “Breastfeeding: an act of love”. Data collection took place in two moments (pre-test and post-test). Ethics Committee approved the project under protocol No. 058657.
Results: Data analysis revealed that 41.6% of the interviewees stated that they did not receive guidance about breast problems from any professional during prenatal care, and 22% reported having presented nipple fissures. Regarding the initiation of breastfeeding, 11.1% of the women interviewed did not knowthe importance of colostrum, and 30.6% did not know its benefits. Assessment of the mothers’ knowledge before and after the intervention obtained a percentage of correctness of 50.7% and 70%, respectively.
Conclusion: The educational activity to encourage breastfeeding was able to increase the mothers’ knowledge about breastfeeding and its health benefits for women and children. It is imperative to carry out activities such as the one proposed in this study, which enables the prevention of several problems that directly affect the health of families, acting effectively to promote a solid knowledge for the population.
Keywords: Breast Feeding. Child Health. Health Education. Infant Nutrition. Food and Nutrition Education.