bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing the capability frontier: Key attributes determining the development of capabilities
Authors: Goncalves Paulo , Sentürk Feyyaz , Andreeva Mariya , Mamashli Zakie 
Published: September 2024

AbstractSystem Dynamics research on capability traps, where organizations remain in low capability and performance equilibrium because of poor resource allocation, spans over two decades and various industries, including agriculture, industry, and humanitarian aid. However, there is a gap in understanding how specific capability attributes affect resource allocation decisions. This study advances the capability trap literature by developing a theoretical model analyzing how key capability attributes—development time, erosion time, and productivity—impact organizational performance and managers' decisions. We introduce the concept of a “capability region”, an attractive area for capability investments, delineated by a “capability frontier” determined by threshold values of these three attributes. This model helps managers understand the factors driving capability development and supports better decision‐making, especially in sustainable practices. By identifying where sustainability‐related capability investments are likely to succeed, this research offers practical guidance for organizations to escape or avoid capability traps, promoting sustainable growth and adaptation.
The cardamom conundrum resolved: Recircumscription and placement of Elettaria in the only pantropically distributed ginger lineage
Authors: Poulsen Axel Dalberg , Fér Tomáš , Marasinghe Lakmini Darshika Kumarage , Sabu Mamiyil , Hughes Mark , Valderrama Eugenio , Leong‐Škorničková Jana 
Published: September 2024

AbstractThe overarching aim of the present study is to sort out the taxonomy of a group of gingers that include the useful and worldwide economically important green cardamom, Elettaria cardamomum, and its wild relatives, to highlight potentially overlooked genetic resources. These species occur naturally in India and Sri Lanka, and our study facilitates more appropriate management priorities for the remaining forest fragments in which they occur. We used NGS Hyb‐Seq methods and sampled four species of the Alpinia I (Fax) clade, six representatives of Aframomum and Renealmia as well as two other basally flowering Sri Lankan species. This is the only pantropically distributed lineage within the entire family, and our result shows that the Alpinia I clade in fact is simply the genus Elettaria (confined to India and Sri Lanka), which is sister to the genera Aframomum (Africa) and Renealmia (Africa and Neotropics). The taxonomic implications are: (1) a recircumscription of Elettaria comprising seven species (E. cardamomum, E. ensal, E. floribunda, E. involucrata, E. rufescens as well as two new species, E. facifera and E. tulipifera described here); (2) the Sri Lankan endemic genus Cyphostigma should be retained; (3) the new monotypic genus, Srilankanthus endemic in Sri Lanka, is described with S. nemoralis, formerly Amomum nemorale, as type. A key is provided to the seven species of Elettaria and lectotypifications are made for five species (Cyphostigma pulchellum, Elettaria floribunda, E. involucrata, E. nemoralis, E. rufescens).
Exosomes of immune cell origin and their therapeutic potential for tumors
Authors: Ai Hongru , Zou Yitan , Zheng Xinya , Li Guangyao , Lei Changhai , Fu Wenyan , Hu Shi 
Published: September 2024

AbstractExosomes are nanoscale membrane vesicles identified by electron microscopy in 1946. They are approximately 30–150 nm in size. Originally, exosomes were thought to be used to eliminate excess components from cells to maintain their normal physiology. Later, it was found that the function and targeting of specific cellular components in exosomes have important implications for the regulation of cellular communication. In the last few years, exosomes have been linked to tumors, infections, and other diseases. New advances in cancer immunotherapy have occurred as a result of the identification of exosomes of immune cell origin, expanding the existing anticancer immune response. This article details exosomes derived from dendritic cells, T lymphocytes (CD4+ T cells, CD8+ T cells, and CAR‐T cells), natural killer cells, and their promising applications in tumor therapy.
Photoacoustic Techniques for Bone Characterization
Authors: Feng Ting , Xie Weiya , Xu Wenyi , Gao Ya , Liu Teng , Ta Dean , Qian Menglu , Cheng Qian 
Published: September 2024

AbstractBiomedical photoacoustics (PA) combines the advantages of selective optical absorption of biological tissues and high penetration depth of ultrasound, providing information on the macroscopic physiological structure and microscopic molecular level of biological tissues. Thus, it has great potential in the application of biomedical diagnosis. Among them, PA detection of bone is an important branch. In contrast to soft tissue, which can be regarded as a homogeneous medium, bone tissue is a two-phase complex medium (mineralized bone trabecular network in the solid phase and embedded bone marrow in the liquid phase), and this anisotropic and heterogeneous structure poses significant challenges to bone tissue characterization methods based on PA technology. This chapter introduces our work on PA detection for complex bone tissue, including the principle of PA wave generation and propagation, the methods of PA imaging and spectrum analysis, and their clinical applications. Finally, this chapter analyzes the current challenges in this field and anticipates future development trends based on the current research status of the PA technology.
Historische Entwicklung von Mobilitätssystemen: Vom Eisenbahnzeitalter zur Automobilgesellschaft
Authors: Haefeli Ueli 
Published: September 2024

ZusammenfassungDer Beitrag skizziert die Entwicklung der Verkehrs- und Mobilitätsgeschichte (West-)Deutschlands seit dem 19. Jahrhundert. Es wird gezeigt, dass bereits die Verkehrsmittel vor dem Auto (vor allem Eisenbahn, Dampfschiff und Fahrrad) Deutschland einen grossen Wohlstandsgewinn gebracht haben. Die Analyse betont die verkehrsmittelunabhängige und kontinuierliche Zunahme der Verkehrsleistungen seit dem 19. Jahrhundert. Bezüglich der Verkehrswende könnte die historische Perspektive neue Akzente setzen: So wenig die Verkehrspolitik weiterhin das Auto bevorzugen sollte, so falsch wäre es, die Verkehrswende lediglich an einem veränderten Verhältnis zum Auto zu messen. Dies macht gerade die enorme Zunahme des Flugverkehrs deutlich. Zu adressieren wäre vielmehr, inwiefern unser Verhältnis zur Mobilität weiterhin vor allem durch „schneller“ und „weiter“ geprägt sein soll.
Early prediction of platelet recovery with immature platelet fraction in patients receiving hematopoietic stem cell transplantation
Authors: Yang Tsung-Han , Tsai Chun-Kuang , Wang Hao-Yuan , Ko Po-Shen , Chien Sheng-Hsuan , Lin Ting-An , Chen Wen-Chun , Hsu Te-Lin , Yeh Chiu-Mei , Lu Ching-I , Lin Wan-Jou , Chen Ying-Ju , Liu Chia-Jen , Liu Chun-Yu 
Published: September 2024

AbstractHematopoietic stem cell transplantation (HSCT) is pivotal in treating hematologic disorders, yet it poses the risk of post-transplantation pancytopenia. Prophylactic platelet transfusions are often administered to mitigate this risk. Utilizing practical markers, such as immature platelet fraction (IPF), to predict hematopoietic recovery in advance could reduce unnecessary prophylactic transfusions. Our prospective study, involving 53 HSCT patients at Taipei Veterans General Hospital between September 2022 and May 2023, utilized the Sysmex XN analyzer to assess peripheral blood cell parameters. We investigated whether IPF could predict platelet recovery early, determined the optimal cut-off value, and compared platelet usage. Neutrophil and platelet engraftment occurred 10 (median; range: 10–12) and 15 (median; range: 15–18) days post-HSCT. Notably, 71.7% of patients exhibited an IPF increase exceeding 2% before platelet recovery. The optimal cut-off IPF on day 10 for predicting platelet recovery within five days was 2.15% (specificity 0.89, sensitivity 0.65). On average, patients received 3.89 units of post-transplantation platelet transfusion. Our results indicate that IPF serves as a predictive marker for platelet engraftment, peaking before the increase in platelet count. This insight aids clinicians in assessing the need for prophylactic platelet transfusions. Integrating reference IPF values alongside platelet counts enhances the accuracy of evaluating a patient’s hematopoietic recovery status. Anticipating the timing of platelet recovery optimizes blood product usage and mitigates transfusion reaction risks.
The risk for rectal cancer recurrence and overall mortality is not increased in men previously diagnosed with prostate cancer: a report from the Swedish colorectal cancer registry
Authors: Sverrisson Ingvar , Smedh Kenneth , Chabok Abbas , Nikberg Maziar 
Published: September 2024

Abstract
Introduction
Limited data exists on oncological outcomes following rectal cancer surgery in men who have previously been diagnosed with prostate cancer (PC). This study aimed to assess overall mortality and rectal cancer recurrence in men previously diagnosed with PC who underwent bowel resection.

Methods
Data from the Swedish Colorectal Cancer Registry identified men who had rectal cancer surgery between 2000 and 2016, and the National Prostate Cancer Registry was used to identify those with a prior PC diagnosis. Cox regression analysis with propensity score matching was employed for data analysis. The primary outcome was overall mortality. Secondary outcome was recurrence for rectal cancer.

Results
Out of 13,299 men undergoing bowel resection for rectal cancer between 2000 and 2016, 1130 had a history of PC. Overall mortality did not significantly differ between men with and without a prior PC diagnosis. Cox regression analyses with propensity score matching revealed that men with previously diagnosed low- or intermediate-risk (HR, 0.79; 95% CI, 0.70–0.90) and high-risk PC (HR, 0.85; 95% CI, 0.74–0.98) had lower overall mortality after rectal cancer surgery compared with men without a PC. There was no significant difference in rectal cancer recurrence between men with a previous low or intermediate-risk PC (HR, 0.92; 95% CI, 0.74–1.14) or high-risk PC (HR, 0.73; 95% CI, 0.52–1.01) compared with those without PC history.

Conclusion
Men undergoing rectal cancer surgery with a previous diagnosis of prostate cancer do not experience an increased risk of rectal cancer recurrence or overall mortality compared with men without a previous history of prostate cancer.
Diffusion tensor imaging and gray matter volumetry to evaluate cerebral remodeling processes after a pure motor stroke: a longitudinal study
Authors: Loubinoux Isabelle , Lafuma Marie , Rigal Julien , Colitti Nina , Albucher Jean-François , Raposo Nicolas , Planton Mélanie , Olivot Jean-Marc , Chollet François 
Published: September 2024

Abstract
Background and objectives
Clinical factors are not sufficient to fix a prognosis of recovery after stroke. Pyramidal tract or alternate motor fiber (aMF: reticulo-, rubrospinal pathways and transcallosal fibers) integrity and remodeling processes assessable by diffusion tensor MRI (DTI) and voxel-based morphometry (VBM) may be of interest. The primary objective was to study longitudinal cortical brain changes using VBM and longitudinal corticospinal tract changes using DTI during the first 4 months after lacunar cerebral infarction. The second objective was to determine which changes were correlated to clinical improvement.

Methods
Twenty-one patients with deep brain ischemic infarct with pure motor deficit (NIHSS score ≥ 2) were recruited at Purpan Hospital and included. Motor deficit was measured [Nine peg hole test (NPHT), dynamometer (DYN), Hand-Tapping Test (HTT)], and a 3T MRI scan (VBM and DTI) was performed during the acute and subacute phases.

Results
White matter changes: corticospinal fractional anisotropy (FACST) was significantly reduced at follow-up (approximately 4 months) on the lesion side. FAr (FA ratio in affected/unaffected hemispheres) in the corona radiata was correlated to the motor performance at the NPHT, DYN, and HTT at follow-up. The presence of aMFs was not associated with the extent of recovery. Grey matter changes: VBM showed significant increased cortical thickness in the ipsilesional premotor cortex at follow-up. VBM changes in the anterior cingulum positively correlated with improvement in motor measures between baseline and follow-up.

Discussion
To our knowledge, this study is original because is a longitudinal study combining VBM and DTI during the first 4 months after stroke in a series of patients selected on pure motor deficit. Our data would suggest that good recovery relies on spared CST fibers, probably from the premotor cortex, rather than on the aMF in this group with mild motor deficit. The present study suggests that VBM and FACST could provide reliable biomarkers of post-stroke atrophy, reorganization, plasticity and recovery.

ClinicalTrials.gov Identifier
NCT01862172, registered May 24, 2013
Anti-sulfatide antibodies in neurological disorders: should we test?
Authors: Kleiser Benedict , Giesche Niklas , Kowarik Markus C. , Dubois Evelyn , Armbruster Marcel , Grimm Alexander , Marquetand Justus 
Published: September 2024

Abstract
Objective
Neurological autoimmune peripheral and central nervous system disorders can be associated with anti-sulfatide antibodies. These antibodies are considered potential diagnostic biomarkers, although their additional diagnostic value in neurological fields has been increasingly questioned. Given the little evidence of anti-sulfatide antibodies’ frequency and diagnostic value in neurology, we aimed to fill this knowledge gap by investigating 10 years of data.

Methods
This retrospective study analyzed the results of the anti-ganglioside dot kits (GA Generic Assays GmbH) from 1318 serum samples and 462 cerebrospinal fluid (CSF) samples for the frequency, sensitivity, and specificity of anti-sulfatide antibodies in neurological disorders.

Results
Although anti-sulfatide antibodies are rarely present in neurological autoimmune disorders (serum IgM 2.5%, IgG 4.6%), they are also present in non-autoimmune diseases (serum IgM 1.2%, IgG 2.5%) and lack sensitivity and specificity towards being a diagnostic marker. Furthermore, anti-sulfatide antibodies are rarely found in CSF (e.g., no positive results for IgM), and including so-called borderline results ((+)) increases sensitivity and the false-positive rate in serum and CSF.

Discussion
While anti-sulfatide antibodies appear more frequently in neurological autoimmune diseases, they are rare overall and provide very limited diagnostic value in determining specific neurological diseases and—more importantly—if a neurological disease has a potential autoimmune etiology.
“New food cultures” and the absent food citizen: immigrants in urban food policy discourse
Authors: Bonnevera Isabela 
Published: September 2024

Abstract
Multicultural cities in the Global North are rapidly developing and releasing urban food policies that outline municipal visions of sustainable food systems. In turn, these policies shape conceptions of food citizenship in the city. While these policies largely absorb activities previously associated with “alternative” food systems, little is known about how they respond to critical food and race scholars who have noted that these food practices and spaces have historically marginalized immigrants. A critical discourse analysis of 22 urban food policies from Global North cities reveals that most policies do not meaningfully consider immigrant foodscapes, foodways, and food-related labour. Many promote hegemonic and/or ethno-nationalistic understandings of “healthy” and “sustainable” food without recognizing immigrants’ food-related knowledge and skills. Policies largely fail to connect the topic of immigrant labour with goals like shortening supply chains, subject immigrant neighbourhoods to stigmatizing health discourses, and lack acknowledgement of the barriers immigrants may face to participating in sustainable food systems. Relatedly, policy discourses articulate forms of food citizenship that emphasize individual obligations over rights related to food. This jeopardizes the potential for immigrants to be seen as belonging to dominant political urban food communities and benefitting from the symbolic and material rewards associated with them.
Learning mobility in European higher education: How has the Union’s flagship initiative progressed?
Authors: Pereira Miguel Alves , D’Inverno Giovanna , Camanho Ana Santos 
Published: September 2024

AbstractIn 2010, the European Commission set out the development of an economy based on knowledge and innovation as one of the priorities of its Europe 2020 strategy for smart, sustainable, and inclusive growth. This culminated in the ‘Youth on the Move’ flagship initiative, aimed at enhancing the performance and international attractiveness of Europe’s higher education institutions and raising the Union’s overall education and training levels. Therefore, it is relevant to assess the performance of the ‘Youth on the Move’ initiative via the creation of composite indicators (CIs) and, ultimately, monitor the progress made by European countries in creating a positive environment supporting learner mobility. For this reason, we make use of the CI-building ‘Benefit-of-the-Doubt’ approach, in its robust and conditional setting to account for outliers and the human development of those nations, to exploit the European Commission’s Mobility Scoreboard framework between 2015/2016 and 2022/2023. Furthermore, we incorporate the value judgements of experts in the sector to construct utility scales and compute weight restrictions through multi-criteria decision analysis. This enables the conversion of ordinal scales into interval ones based on knowledgeable information about reality in higher education. In the end, the results point to a slight performance improvement, but highlight the need to improve the ‘Recognition of learning outcomes’, ‘Foreign language preparation’, and ‘Information and guidance’.
Fine-grained gaze estimation based on the combination of regression and classification losses
Authors: Abdelrahman Ahmed A. , Hempel Thorsten , Khalifa Aly , Al-Hamadi Ayoub 
Published: September 2024

AbstractHuman gaze is a crucial cue used in various applications such as human-robot interaction, autonomous driving, and virtual reality. Recently, convolution neural network (CNN) approaches have made notable progress in predicting gaze angels. However, estimating accurate gaze direction in-the-wild is still a challenging problem due to the difficulty of obtaining the most crucial gaze information that exists in the eye area which constitutes a small part of the face images. In this paper, we introduce a novel two-branch CNN architecture with a multi-loss approach to estimate gaze angles (pitch and yaw) from face images. Our approach utilizes separate fully connected layers for each gaze angle prediction, allowing explicit learning of discriminative features and emphasizing the distinct information associated with each gaze angle. Moreover, we adopt a multi-loss approach, incorporating both classification and regression losses. This allows for joint optimization of the combined loss for each gaze angle, resulting in improved overall gaze performance. To evaluate our model, we conduct experiments on three popular datasets collected under unconstrained settings: MPIIFaceGaze, Gaze360, and RT-GENE. Our proposed model surpasses current state-of-the-art methods and achieves state-of-the-art performance on all three datasets, showcasing its superior capability in gaze estimation.
Maternal Accommodation of Adolescent Body Dysmorphic Disorder: Clinical Correlates and Association with Treatment Outcomes
Authors: Hogg E. , Krebs G. , Mataix-Cols D. , Jassi A. 
Published: September 2024

AbstractFamily accommodation (FA) is widely-recognised as an important clinical phenomenon in obsessive–compulsive disorder (OCD) and anxiety disorders, and is related to poorer treatment outcomes. However, FA has not been quantitatively explored in Body Dysmorphic Disorder (BDD). The aim of this study was to investigate the patterns and correlates of maternal accommodation in adolescent BDD, and its association with treatment outcomes. Participants were 131 adolescents with BDD and their mothers who completed the Family Accommodation Scale—Parent Report (FAS-PR) as part of routine clinical practice in a National and Specialist Service for Young People at the Maudsley Hospital, London. Seventy-six (58%) young people received specialist cognitive behavioural therapy for BDD and had post-treatment data available. All mothers engaged in at least one form of accommodation. Providing reassurance (98.5%) and assisting avoidance (88.5%) were the most commonly endorsed behaviours. Levels of accommodation were positively associated with clinician-rated BDD symptom severity (r = 0.18, p = 0.041) and maternal symptoms of anxiety, depression and stress (r = 0.41, p < 0.001), and negatively associated with child global functioning (r = –0.38, p < 0.001). Maternal accommodation did not predict treatment outcomes (β = 0.055, p > 0.05). The findings indicate that maternal accommodation is common and has important clinical correlates, but does not impact on treatment response. Consequently, the relationship between maternal accommodation and BDD symptoms may differ to that evidenced in paediatric OCD. Future longitudinal research exploring maternal and paternal accommodation, and assessing variables of interest at multiple time-points throughout treatment, is needed to advance understanding of the role of FA in adolescent BDD.
Use of systemic hormonal contraception and risk of attempted suicide: a nested case–control study
Authors: Toffol Elena , Partonen Timo , Heikinheimo Oskari , But Anna , Latvala Antti , Haukka Jari 
Published: September 2024

AbstractEvidence regarding the role of hormonal contraception (HC) as a risk factor for attempted suicide is inconclusive. Thus, this study aimed to assess the associations of use of different types of systemic HC with the risk of attempted suicide in women aged 15–49 years. Data on a population-based cohort (n = 587,823) of HC users and non-users in 2017 was derived from national registers in Finland. In a nested case–control design we examined the risk of attempted suicide in relation to current HC use (past six months) via multivariable conditional logistic regression models. During the follow-up (from 2018 to 2019) there were 1.174,346 million person-years of which 818 cases of suicide attempts were observed (incidence rate: 0.70 per 1000 person-years). Use of HC, especially combined hormonal contraceptives, was not associated with a higher risk of attempted suicide compared to non-use (OR 0.68, 95% CI 0.45–1.02) after controlling for marital status, socioeconomic status, education, chronic diseases, recent delivery, recent psychiatric hospitalizations, and current use of psychotropic medications. In women without psychiatric history, current HC use (OR 0.73, 95% CI 0.58–0.91), especially ethinylestradiol-containing preparations (OR 0.54, 95% CI 0.40–0.73), was associated with a lower risk of attempted suicide. After adjusting for recent psychiatric hospitalizations and use of psychotropic medications, current use of progestin-only preparations was not associated with attempted suicide. In conclusion, current HC use was not associated with an increased risk of attempted suicide in fertile-aged women.