bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Evaluation of lncRNA A2M-AS1 Gene Expression in Multiple Sclerosis Patients
Authors: Mohammadi Shaghayegh , Sadeghiyan Tahereh , Rezaei Mohammad , Azadeh Mansoureh 
Published: September 2024

Background:
Multiple sclerosis (MS) is one of the three leading neurodegenerative diseases worldwide. Gene expression profile studies play an important role in recognizing and preventing disease. Considering the inherent ability of biomarkers to diagnose and prognose the occurrence of a disease, with the aim of gene therapy and changing gene expression, it can be helped to treat it. In this study, by examining the gene interaction and expression of non-coding genes in patients with MS, using bioinformatics analyses, laboratory research and potential non-coding diagnostic biomarkers of MS were selected for further investigations.

Materials and Methods:
First, by using micro-array data analysis of the GEO database, the expression status of the long non-coding ribonucleic acid (RNA) (lncRNA) A2M-AS1 gene was investigated in patients with MS. lncRNA–mRNA interaction analysis was performed in the lncRRisearch database. After sample collection, the total RNA extracted using the RNA extraction kit from 20 patient samples and 20 healthy samples was synthesized into cDNA with the synthesis kit. The quantitative reverse transcriptase polymerase chain reaction experiment was performed for the final validation of expression change.

Results:
Based on bioinformatic and laboratory analysis, the expression of the A2M-AS1 gene in MS samples showed a significant decrease in expression compared to healthy samples. Also, based on the receiver operating characteristic analysis, lncRNA A2M-AS1 can be introduced as an acceptable diagnostic biomarker to distinguish MS samples from healthy samples.

Conclusion:
lncRNA A2M-AS1, by reducing its expression as an acceptable diagnostic biomarker, can increase the risk of developing MS.
Spreading, flattening, and logarithmic lag for reaction-diffusion equations in $\mathbb{R}^{N}$: Old and new results
Authors: Hamel François , Rossi Luca 
Published: September 2024

This paper is concerned with the large-time dynamics of bounded solutions of reaction-diffusion equations with bounded or unbounded initial support in

\R^{N}

. We start with a survey of some old and recent results on the spreading speeds of the solutions and their asymptotic local one-dimensional symmetry. We then derive some flattening properties of the level sets of the solutions if initially supported on subgraphs. We also investigate the special case of asymptotically conical-shaped initial conditions. Lastly, we reclaim some known results about the logarithmic lag between the position of the solutions and that of planar or spherical fronts expanding with minimal speed, for almost-planar or compactly supported initial conditions. We then prove some new logarithmic-in-time estimates of the lag of the position of the solutions with respect to that of a planar front, for initial conditions which are supported on subgraphs with logarithmic growth at infinity. These estimates entail in particular that the same lag as for compactly supported initial data holds true for a class of unbounded initial supports. The paper also contains some related conjectures and open problems.
Psychological Impact in Individuals with Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
Authors: Patel Tanvi H. , Bachu Ramya , Shrivastava Trilok , Alrawabdeh Jawad , Alzubi Marah , Hastings Jael , Dean Harold , Schinke Carolina , Thanendrarajan Sharmilan , Zangari Maurizio , Tricot Guido , Zhan Fenghuang , Shaughnessy John D , van Rhee Frits , Al Hadidi Samer 
Published: September 2024

In our study of 246 newly diagnosed individuals with MGUS or SMM (115 MGUS, 131 SMM), we found that 19% reported anxiety, with no significant difference between the MGUS and SMM groups (22% vs. 17%). Those with a history of psychiatric disorders or belonging to certain racial groups were more likely to experience anxiety. Initial coping responses included religious coping, denial, frustration, irritability, and seeking social support. Given anxiety’s detrimental effects, our findings emphasize the importance of incorporating psychosocial assessments to optimize care for MGUS and SMM patients.
Relationship of Communication, Negotiation and Leadership on the Employee Performance for Sustainable Growth in Hotels
Authors: Hoo Wong Chee , Qi Zhu , Wolor Christian Wiradendi , Ismail Mohammad , Prompanyo Manoch 
Published: September 2024

Objective: This research aims to investigate what soft skills affect the performance of employees at Hotels for their sustainable growth in China. Sustainable Development Goals (SDG) 8, promote sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all.

Theoretical Framework: The study’s underpinning theory was derived from the Lippman, Ryberg, Carney and Moore (2015) model of key softskills.

Method: This study adopts convenience sampling and analyzes the data from 158 questionnaires distributed through SPSS. The analysis results will find out the more important and useful skills in hotels. This study was conducted at the Guizhou Province, China using online survey. Three soft skills of communication, negotiation, and leadership were tested to be positively correlated with the performance of hotel employees.

Results and Discussion: This research also allowed us to identify which soft skills are most important to a team to enable the overall team to succeed. This research can provide a reference for the human resource management of hotels to plan the soft skill development training of employees.
More and more companies realize that employees are one of the important factors for the company’s further development. If you want to develop better in the information age, you must have a group of outstanding employees. Therefore, the training plan to improve employee performance is a relatively important work in human resource management. Hard skills are just our visible professional and technical indicators, while soft skills are invisible indicators, and they are also a scale to measure a person's ability to handle things.

Research Implications: Academic implication sees the use of Lippman et al (2015) model in underpin the variables related in the study of employee performance and soft skills. Practical implication include to emphasize the role of negotiation skills foe the employee performance.

Originality/Value: This study provide insight on the role of negotiation skill in increasing the employee performance in the hospitality industry in China.
Monkeypox- need for Vigilant Health system and Regulations towards a Global Health Threat
Authors: Jain Seema 
Published: September 2024

A viral illness caused by the monkey pox virus, monkeypox is now known as Mpox. It is a zoonotic infectious disease causing painful rash, enlarged lymph nodes, fever, headache, muscle ache, backpain and low energy.
According to WHO, most cases in 2022 were in Africa but later m-pox was reported from USA, Europe Australia & Canada. Mpox continues to be a threat today, with upsurge of cases in Democratic Republic of Congo and other countries in Africa. Since 2022, there has also been an upsurge in mpox cases and deaths in the Democratic Republic of the Congo. Over 120 countries have reported mpox between Jan 2022-Aug 2024, with over 1,00,000 laboratory-confirmed cases reported and over 220 deaths among confirmed cases. In India, MoHFW reported 30 cases in the last 2022 outbreak, with last case occurring in March 2024.

The monkeypox virus was discovered in Denmark (1958) in monkeys kept for research. The first reported human case of mpox was a nine-month-old boy in the Democratic Republic of the Congo (1970). Mpox steadily emerged in central, east and west Africa following the eradication of smallpox in 1980 and the end of smallpox vaccination worldwide. In 2003, there was an outbreak in the United States of America, linked to imported wild animals. Since 2005, thousands of cases are reported in the Democratic Republic of the Congo every year.
In May 2022, an outbreak of mpox appeared suddenly and rapidly spread across Europe, the Americas and then all six WHO regions including refugee camps in the Republic of the Sudan.
Spurious Accelerations in Finite Element Analysis of Geotechnical Problems: Cause and Remedy
Authors: Chavan Dhanaji 
Published: September 2024

Present study investigates the response of the two distinct geotechnical problems under earthquake loading. These two problems are: 1) nailed soil slope and 2) 1-D site response analysis. The aim of the study is to understand the cause of spurious accelerations and suggest a remedy. Two distinct interface conditions were considered in modelling the nailed soil slope. In first, the soil nail interface was considered to be perfectly bonded. In second case, the sliding at the interface was allowed. The analysis resulted into the physically acceptable deformations. However, the dumbbell shaped spurious acceleration pattern was observed in perfect bonding case. Further, the maximum acceleration was found to span from 4 g to 13 g. Such extremely high accelerations are unphysical and hence, unacceptable. In case of 1-D site response analysis, misleading acceleration spike of magnitude twice that of true acceleration was noted. The introduction of the numerical damping successfully removed the spurious accelerations and resulted in physically acceptable response for both problems.

Received: 30 May 2024 | Revised: 30 August 2024 | Accepted: 20 September 2024

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
Dhanaji Chavan: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing.
New strategic initiatives of China to integrate the Greater Central Asia space
Authors: Матвеев В.А. 
Published: September 2024

Статья исходит из того, что развивающийся мировой экономический кризис имеет существенные геополитические причины. Он оказывает значимое деструктивное влияние на развитие стран Евразии. Страны постсоветского пространства ведут поиск дополнительных источников и стимулов экономического роста, среди которых весомым является продолжающийся процесс евразийской интеграции. Одним из основных мотивов реализации инициативы “Пояс и путь” (ИПП), наряду с инфраструктурными интересами Китая, становится нацеленность КНР на региональную интеграцию, прежде всего с соседями. Из-за особого геостратегического положения Синьцзян-Уйгурского автономного района КНР (СУАР КНР) на границе с Центрально-Азиатским регионом и Средним Востоком ему предназначена особая роль в развитии ИПП. Китай стремится придать ряд дополнительных импульсов экономическому и социальному развитию СУАР. В статье анализируются особенности и новации экспериментальной зоны свободной торговли, создаваемой в Синьцзяне с 2023 г. Основной вывод статьи заключается в том, что в трансграничной китайско-центральноазиатской полосе начинают складываться предпосылки для формирования экономического пояса роста, что в долгосрочной перспективе делает возможным создание международного экономического региона.
The article proceeds from the fact that the developing global economic crisis has significant geopolitical reasons. It has a significant destructive impact on the development of Eurasian countries. The countries of the post-Soviet space are searching for additional sources and incentives for economic growth, among which the ongoing process of Eurasian integration is significant. One of the main motives for the implementation of the Belt and Road Initiative (BRI), along with China’s infrastructure interests, is the PRC’s focus on regional integration, primarily with its neighbors. Due to the special geostrategic position of the Xinjiang Uygur Autonomous Region of the People's Republic of China (XUAR of the People's Republic of China) on the border with the Central Asian region and the Middle East, it has a special role in the development of the BRI. China is striving to give a number of additional impetuses to the economic and social development of the XUAR. The article analyzes the features and innovations of the experimental free trade zone created in Xinjiang from 2023. The main conclusion of the article is that in the cross-border Chinese-Central Asian zone, the prerequisites for the formation of an economic growth belt are beginning to take shape, which in the long term makes it possible to create an international economic region.
Environmental strategy of the PRC: domestic and foreign policy aspects
Authors: Виноградов А.О. , Долгополов К.А. 
Published: September 2024

Ухудшение экологической ситуации в мире привлекает внимание мирового сообщества, заставляет искать и применять новые решения в области науки и техники с целью адаптации к сложившейся ситуации. Китай, будучи мировым лидером по объемам выбросов парниковых газов в атмосферу, активно оптимизирует свою энергетическую стратегию, стимулируя развитие возобновляемых источников энергии. В статье оценивается результативность курса Китая на постепенный энергетический переход как элемент экологической политики страны. Определятся соответствие текущего состояния энергетического перехода экологическим целям Китая, в том числе закреп­лённым в международных соглашениях. Рассматриваются внешнеполитические аспекты экологической политики Китая, в частности — позиционирование КНР на мировом рынке альтернативной энергии. По мнению авторов статьи, стратегия, выбранная КНР в движении по пути энергетического перехода, преследует не столько экологические цели, сколько геополитические: она позволяет КНР занять лидирующие позиции на рынке возобновляемых источников энергии (ВИЭ) и снизить геополитические риски, связанные с зависимостью от импорта традиционного топлива.
The deterioration of the environmental situation in the world attracts the attention of the world community, forcing it to look for and apply new solutions in the field of science and technology in order to adapt to the current situation. China, being the world leader in greenhouse gas emissions into the atmosphere, is actively optimizing its energy strategy, stimulating the development of renewable energy sources. The article evaluates the effectiveness of China's policy towards a gradual energy transition as an element of the country's environmental policy. The compliance of the current state of the energy transition with China’s environmental goals, including those fixes in international agreements, is determined. The foreign policy aspects of China's environmental policy are considered, in particular the positioning of China in the global alternative energy market. According to the authors of the article, the strategy chosen by China in moving along the path of energy transition does not pursue environmental goals, but pursues geopolitical goals — it allows China to take a leading position in the renewable energy market and reduce the geopolitical risks associated with dependence on imports of traditional fuel.
On China’s new initiatives in the sphere of global governance (as of autumn 2023)
Authors: Меркулов К.К. 
Published: September 2024

Особое внимание в статье уделено анализу содержания документа “Предложение Китайской Народной Республики о реформе и развитии глобального управления”, обнародованного МИД КНР 13 сентября 2023 г. с целью детализации прежних глобальных инициатив председателя КНР Си Цзиньпина и МИД КНР, и выпущенных Информационным бюро Госсовета КНР двух новых Белых книг: “Глобальное сообщество общего будущего: предложения и действия Китая” (26 сентября 2023 г.) и “Инициатива “Пояс и путь”: ключевой столп глобального сообщества общего будущего” (10 октября 2023 г.). В статье также характеризуются оценки этих документов рядом зарубежных экспертов. В числе основных выводов данной научно-исследовательской разработки (НИР) можно привести положение о крайней желательности создания в структуре РАН и/или других заинтересованных инстанций сети научно-исследовательских лабораторий не только по прогнозированию, но и системному моделированию параметров нового складывющегся мироустройства.
The article pays particular attention to the analysis of the content of the document titled “The Proposal of the People's Republic of China on the Reform and Development of Global Governance”, published by the Ministry of Foreign Affairs of the People's Republic of China on September 13, 2023 in order to detail the previous global initiatives of the President of the PRC Xi Jinping and the Ministry of Foreign Affairs of the People's Republic of China, as well as issued by the Information Bureau of the State Council of the People's Republic of China two new White Papers “A Global Community for a Shared Future: China's Proposals and Actions” (September 26, 2023) and “The Belt and Road Initiative: A Key Pillar of a Global Community for a Shared Future” (October 10, 2023). The article also characterizes the assessments of these documents by a number of foreign experts. Among the main conclusions of this research development is the provision on the extreme desirability of creating within the structure of the Russian Academy of Sciences and/or other interested authoritative bodies a network of research laboratories not only for forecasting, but also for systematic modeling of the parameters of a new, emerging world order.
Particle size analysis of mixed sediments in oscillating flows with mobile beds
Authors: Abreu Tiago , C. Ferreira Caroline , Matos João , Bernabeu Ana M. , A. Silva Paulo 
Published: September 2024

The dynamics of beaches encompass complex mechanisms in sediment transport, which are contingent on the heterogeneous nature of sands. Understanding these mechanisms is crucial for morphodynamic modeling. This study conducted a thorough analysis of the vertical granulometric distribution of sediments on the bed, relying on laboratory experiments carried out in a wave flume and employing a laser particle counter. The bed was covered with sand mixtures obtained from two well-sorted grain-size fractions: a fine sediment (F) with a median diameter of 0.21 mm and a coarse sediment (C) with a median diameter of 0.58 mm. As observed in the experiments analyzed in this study, the initially homogeneous bed composition undergoes changes, illustrating a trend toward coarsening in the majority of the layers.
Análisis sedimentológico de las playas del norte del municipio de Telde (Gran Canaria, España): Experiencia didáctica
Authors: Montoya Montes Isabel , Sánchez García María José , Alonso Bilbao Ignacio , Mangas José , 2º curso del Grado en CC del Mar Alumnos 
Published: September 2024

Este artículo describe una experiencia didáctica desarrollada con el alumnado de 2º curso del grado en Ciencias del Mar en la asignatura Medios Sedimentarios Marinos, en la que se aborda el análisis de los sedimentos detríticos de tres playas al norte del municipio de Telde (Gran Canaria), cubriendo varias etapas del método científico, desde el trabajo de campo con la observación, planteamiento de hipótesis y adquisición de datos y muestreos, hasta el análisis en laboratorio, interpretación de resultados y elaboración de un poster en formato de congreso para su publicación. La propuesta pretende familiarizar al alumnado con el análisis de los sedimentos y su relación con los agentes dinámicos que controlan su distribución. La importancia de la experiencia radica en que por primera vez en la titulación que están cursando, el alumnado se enfrenta a un reto científico en el campo de la geología costera que consiguen resolver con éxito
Pendampingan Masyarakat Desa Sendangsari Cerdas Finansial
Authors: Ridayati  , Herna Puji Astutik  
Published: September 2024

Desa Sendangsari membawahi 12 padukuhan. Kegiatan rutin yang dilaksanakan di Desa Sendangsari diantaranya adalah kumpulan PKK yang selalu bertempat di Balai Desa setiap bulan di Minggu ke dua. Anggota PKK desa adalah ibu-ibu yang mewakili PKK Dusun dan 80% nya adalah Ibu Rumah tangga yang berusia Produktif. Tujuan penyuluhan ini adalah untuk memberikan pengetahuan kepada masyarakat Desa Sendangsari tentang pentingnya mengelola keuangan yang baik. Sebagian besar dari masyarakat Desa Sendangsari menghabiskan uangnya untuk keperluan sehari-hari dan tidak ada dana darurat. Untuk mengatasi permasalahan pihak mitra, diperlukan kegiatan penyuluhan dan sosialisasi tentang bagaimana menghitung kebutuhan dan mengelola keuangan dengan bijak menggunakan matematika sederhana sehingga masyarakat akan lebih berhati-hati dalam managemen keuangan pribadinya kepada warga Desa Sendangsari Kapanewon Minggir Kabupaten Sleman Yogyakarta. Hasil kegiatan penyuluhan ini adalah terbentuknya masyarakat yang lebih faham tentang managemen finansial bagi warga Desa Sendangsari Minggir Sleman Yogyakarta.
ĐẶC ĐIỂM PHÂN BỐ VÀ KHÁNG KHÁNG SINH CỦA CÁC LOÀI VI KHUẨN PSEUDOMONAS SPP. PHÂN LẬP TẠI BỆNH VIỆN QUÂN Y 103
Authors: Nguyễn Văn An , Nguyễn Thị Hồng Ngọc 
Published: September 2024

Mục tiêu: Nghiên cứu đặc điểm phân bố và kháng kháng sinh của các loài vi khuẩn Pseudomonas spp. không bao gồm Pseudomonas aeruginosa phân lập từ người bệnh tại Bệnh viện Quân y 103 giai đoạn 2014-2022. Đối tượng và phương pháp nghiên cứu: Thiết kế nghiên cứu mô tả, đối tượng nghiên cứu là các chủng vi khuẩn Pseudomonas spp. phân lập từ người bệnh tại Bệnh viện Quân y 103 giai đoạn 2014-2022. Kết quả: Tổng số 58 chủng Pseudomonas spp. phân lập được trong thời gian nghiên cứu từ 2014-2022, P. putida là loài gây bệnh phổ biến nhất (63,8%). Pseudomonas spp. phân lập được chủ yếu từ người bệnh nam giới (74,1%), nhóm người bệnh ≥ 60 tuổi (43,8%), bệnh phẩm nước tiểu (39,7%), các khoa ngoại (34,5%). Pseudomonas spp. có tỷ lệ nhạy cảm cao nhất với Amikacin (64,8%), tiếp theo là Gentamycin (53,8%) và Tobramycin (52,0%). Ngược lại, các vi khuẩn này kháng cao nhất với các kháng sinh như Trimethoprim/sulfamethoxazole (87,0%), Ticarcillin/clavulanic acid (78,7%) và Levofloxacin (72,0%). Kết luận: Nghiên cứu cho thấy Pseudomonas spp. chủ yếu phân lập từ nước tiểu và bệnh phẩm hô hấp. Pseudomonas putida là loài vi khuẩn gây bệnh phổ biến nhất trong chi Pseudomonas (ngoại trừ Pseudomonas aeruginosa). Pseudomonas spp. kháng cao nhất với Trimethoprim/ sulfamethoxazole, Ticarcillin/ clavulanic acid và Levofloxacin; nhạy cảm cao nhất với Amikacin.
LIÊN QUAN GIỮA BIỂU HIỆN CỦA LNCRNA EPB41L4A-AS1 VÀ IFI6LNC2 VỚI MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, XÉT NGHIỆM Ở BỆNH NHÂN SỐT XUẤT HUYẾT DENGUE
Authors: Nguyễn Minh Nam , Nguyễn Thị Thùy Dịu , Đinh Thị Thu Hằng , Bùi Lan Anh , Rodolfo Katz , Đỗ Tuấn Anh , Ella Sklan , Hoàng Văn Tổng 
Published: September 2024

Mục tiêu: Xác định mối liên quan giữa biểu hiện của lncRNA EPB41L4A-AS1 và IFI6lnc2 với một số đặc điểm lâm sàng, cận lâm sàng ở bệnh nhân sốt xuất huyết Dengue (SXHD). Phương pháp nghiên cứu: So sánh nồng độ các lncRNA ở nhóm bệnh nhân SXHD với các triệu chứng lâm sàng, mức độ xét nghiệm khác nhau. Kết quả: Nồng độ EPB41L4A-AS1 và IFI6lnc2 ở nhóm bệnh nhân SXHD có xét nghiệm anti DENV-IgM, IgG dương tính, xuất huyết dưới da, xuất huyết niêm mạc cao hơn nhóm xét nghiệm âm tính, không có triệu chứng xuất huyết (p<0,05). Ở nhóm tiểu cầu <50G/L; từ 50 đến 100G/L; >100G/L: nồng độ EPB41L4A-AS1 lần lượt là 9,23±10,52; 5,98±8,57; 2,54±10,5 (105copies/ml); nồng độ IFI6lnc2 lần lượt là 6,96±6,11; 4,78±6,04; 1,22±3,54 (105copies/ml); sự khác biệt giữa các nhóm có ý nghĩa (p<0,05). Nồng độ 2 lncRNA thấp nhất ở nhóm enzym gan GOT, GPT <80U/L; tiếp theo đến nhóm từ 80 đến 400U/L; cao nhất ở nhóm >800U/L. Kết luận: LncRNA EPB41L4A-AS1 và IFI6lnc2 biểu hiện cao hơn ở nhóm bệnh nhân có xét nghiệm kháng thể kháng DENV IgM, IgG dương tính; có xuất huyết dưới da; có xuất huyết niêm mạc; nhóm có hoạt độ enzym GOT, GPT cao; số lượng tiểu cầu thấp.