bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partial Anterior Cruciate Ligament Knee Reconstruction with Accelerated Anterior Cruciate Ligament Rehabilitation
Authors: Annear Peter , Henderson AJY 
Published: March 2016

Objectives: The primary purpose of this study is to determine whether or not a partial Anterior Cruciate Ligament (ACL) reconstruction with accelerated rehabilitation produced similar outcomes to that of the conventional ACL reconstruction with its traditional rehabilitation program timeframe. An improved understanding of these outcomes can change the way partial ACL injuries are treated surgically and return patients back to their chosen activities quicker without compromising their graft. Methods: Level III, therapeutic, retrospective study. Participants who were two years post partial ACL reconstruction with accelerated rehabilitation by were contacted. They filled out IKDC, Modified Cincinatti and Tegner Lysholm knee score questionnaires and were measured using a KT-1000 arthrometer for side-to-side instrumented laxity >2 mm as well as indicating if there partial ACL reconstruction had re-ruptured, requiring further surgical intervention. Results: All three measurements in this study, including re-rupture rates, side – to – side instrumental laxity and satisfaction scores via questionnaires, were statistically significant, thus showing a partial ACL reconstruction with accelerated rehabilitation is a viable choice for the treatment of a patient with a partial ACL tear of his knee. Conclusion: Partial ACL reconstruction with accelerated rehabilitation is a viable choice for the treatment of a patient with a partial ACL tear of his knee.
Acute ACL Surgery Decreases First Year Socio Economic Costs Compared to Delayed Reconstruction
Authors: Eriksson Karl , von Essen Christoffer , Barenius Björn 
Published: March 2016

Objectives: Clinical practice has been to avoid acute ACL reconstruction due to the risk of complications, especially arthrofibrosis. Thus, a general rule has been to wait with reconstruction until he knee is “calm” which usually means 4-8 weeks following injury. Furthermore there is often also a prolonged waiting time due to operating space and other logistic factors. Since most of the patients undergoing ACL reconstruction are of working age, there is a potentially large socio-economic loss due to the fact that many of these patients are unable to work from the time of injury to the time of reconstruction. The aim of this study was to assess and compare the total number of sick leave days caused by the knee injury from the day of injury and over the first year between sub acute and delayed reconstruction. Methods: 70 patients with high recreational activity level, Tegner level of 6 or more, who presented with an acute ACL injury were randomized to acute reconstruction within 8 days from the injury or delayed reconstruction 6-10 weeks post injury. Four surgeons performed the ACL reconstructions with quadrupled semitendinosus tendon grafts. Patients were assessed at 6,12 and 24 months and these follow ups included Biodex strength test, Lachman, Rolimeter, pivot shift, one leg hop, IKDC, KOOS, Lysholm and Tegner activity level. With data from the Swedish Social Insurance Agency (Försäkringskassan) information about the number of sick leave days from the day of the knee injury and over the following twelve months was collected. The data was recalled based on diagnostic numbers related to the specific knee-injury and compared between the two groups. Results: Seventy percent of the patients were males, mean age at the time of inclusion was 27 years (18 -41) and the pre-injury median Tegner level was 9 (5-10), with no differences between the groups. 15/70 patients were students without registered compensation for sick leave, 5 in the acute and 10 in the delayed group. 4 patients in the acute group and 1 in the delayed group were neither students nor registered for any compensation for sick leave from work. One patient from the delayed group resigned from the study before surgery. The remaining 49 patients, 26 patients in the acute and 23 in the delayed group received compensation for sick leave due to the injury. The number of sick leave days for the acute group was significantly lower, mean 57 (median 53) days compared to the delayed group, mean 99 (median 66) days (p<0.05). Conclusion: Acute ACL reconstruction seems to significantly reduce socio economic costs (compensation for sick leave) compared to delayed reconstruction. From a nation based perspective this could have major implications in health care spending.
Predicting Hamstring Graft Diameter Using MRI and Anthropometry
Authors: Fritsch Brett A , Mhaskar Vikram A , An Vincent Vinh Gia , Scholes Corey 
Published: March 2016

Objectives: Graft diameter is one variable that may affect outcome of ACL reconstruction. The ability to predict the size of a graft in a given patient pre-operatively may help guide graft selection and preparation technique. Various papers have correlated anthropometric data and MRI tendon measurements to intraoperative graft diameter, although no papers have investigated these together. The intra-operative diameter of a hamstring autograft will be influenced by graft preparation technique. Our study aimed to investigate the prediction of intraoperative graft diameter of 2 different graft construct techniques (4-strand semitendinosus versus quadrupled semitendinosus) using anthropometry and MRI measurements. Methods: Retrospective review of two groups of ACL reconstruction using different graft preparation techniques was performed. “Conventional” 4-strand gracilis + semitendinosus with fixed suspension at the femur and screw fixation at the tibia were compared with quadrupled semitendinosus grafts with adjustable suspensory fixation at each end (Graftlink). Cross-sectional areas (XSA) of the semitendinosus and gracilis tendons was measured in the axial slice of a T2 weighted MRI image using a region-of-interest tool. Stepwise linear regression using intraoperative graft diameter as the dependant variable was performed using MRI XSA of the semitendinosus and gracilis tendons, gender and height as predictors. Results: 129 ACL Reconstruction in 127 patients were done in the time period, 89 of which were done conventionally, and 40 which employed the Graftlink construct. The median graft diameter in the Graftlink group (8.5mm IQR8-9) was greater than that of the conventional group (8mm, IQR 7.5-8) (p < 0.001). MRI XSA of semitendinosus and height were statistically significant predictors of diameter in the Graftlink group (R2 = 51%), whilst MRI XSA of semitendinosus + gracilis and gender were predictors in the conventional group (R2 = 36%). Conclusion: Graftlink ACLRs produced a greater graft diameter than conventional 4-strand semitendinosus and gracilis constructs. Gender and tendon XSA were statistically significant predictors of graft diameter in conventional four-tailed ACLRs, whilst height and tendon XSA predicted Graftlink ACLRs. A greater degree of the graft diameter variance could be predicted pre-operatively in the Graftlink group compared to the conventional construct.
PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression
Authors: Vincent-Fabert Christelle , Platet Nadine , Vandevelde Amelle , Poplineau Mathilde , Koubi Myriam , Finetti Pascal , Tiberi Guillaume , Imbert Anne-Marie , Bertucci François , Duprez Estelle 
Published: March 2016

Key Points
Inactivation of PLZF promotes phenotype of HSC aging. PLZF controls HSC cell cycle.
PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation
Authors: Yamaguchi Munehiro , Zacharia Jennifer , Laidlaw Tanya M , Balestrieri Barbara 
Published: March 2016

Abstract
Phospholipases A2 are enzymes that liberate membrane-bound lipids in a tissue and cell-specific fashion. Group V secretory phospholipase A2 is necessary for the development of M2 macrophages and their effector functions in a mouse model of the T-helper-2 allergic airway inflammation. However, the function of group V phospholipase A2 in human M2 activation and T-helper-2 inflammation is ill-defined. Transglutaminase-2, a protein cross-linking enzyme, is a newly identified marker of both human and mouse interleukin-4-activated M2 macrophages and is also found in the lungs of patients with asthma. We report that group V phospholipase A2 and transglutaminase-2 colocalized in macrophages of human nasal polyp tissue obtained from patients with T-helper-2 eosinophilic inflammation, and their coexpression positively correlated with the number of eosinophils in each tissue specimen. We demonstrate that in human monocyte-derived macrophages activated by interleukin-4, group V phospholipase A2 translocated and colocalized with transglutaminase-2 in the cytoplasm and on the membrane of macrophages. Moreover, knocking down group V phospholipase A2 with small interfering ribonucleic acid reduced macrophage transglutaminase activity, whereas mass spectrometry analysis of lipids also showed reduced prostaglandin E2 production. Finally, exogenous prostaglandin E2 restored transglutaminase activity of group V phospholipase A2-small interfering ribonucleic acid–treated macrophages. Thus, our study shows a novel function of group V phospholipase A2 in regulating the transglutaminase activity of human interleukin-4–activated M2 macrophages through prostaglandin E2 generation and suggests that group V phospholipase A2 is a functionally relevant enzyme that may have therapeutic value for the treatment of human T-helper-2 inflammatory disorders.
Mechanisms Linking the Gut Microbiome and Glucose Metabolism
Authors: Utzschneider Kristina M. , Kratz Mario , Damman Chris J. , Hullarg Meredith 
Published: March 2016

AbstractContext:Type 2 diabetes mellitus is associated with gastrointestinal dysbiosis involving both compositional and functional changes in the gut microbiome. Changes in diet and supplementation with probiotics and prebiotics (ie, fermentable fibers) can induce favorable changes in gut bacterial species and improve glucose homeostasis.Objective:This paper will review the data supporting several potential mechanisms whereby gut dysbiosis contributes to metabolic dysfunction, including microbiota driven increases in systemic lipopolysaccharide concentrations, changes in bile acid metabolism, alterations in short chain fatty acid production, alterations in gut hormone secretion, and changes in circulating branched-chain amino acids.Methods:Data for this review were identified by searching English language references from PubMed and relevant articles.Conclusions:Understanding the mechanisms linking the gut microbiome to glucose metabolism, and the relevant compositional and functional characteristics of the gut microbiome, will help direct future research to develop more targeted approaches or novel compounds aimed at restoring a more healthy gut microbiome as a new approach to prevent and treat type 2 diabetes mellitus and related metabolic conditions.
Conceptual Framework for Methodology of Vertically Integrated Company’s Innovation Development Program Formation
Authors: Чернятин  , Chernyatin S. 
Published: March 2016

The large businesses role in the current Russian and world’s innovation activity practice is considered in
this paper. Priority guidelines for the improvement of innovation development programs (IDP) technology
relating to vertically integrated companies have been identified in the frame of Russian partially governmentowned
companies’ IDP analysis. In particular, key principles for corporate IDP formation, which defined
requirements to this document, as well as methods for their accounting, have been presented. An integrating
stage of the corporate IDP formation process, consisting in the development of a specific methodological
approach to the implementation of the above principles and requirements in the frame of selected methods
for their accounting has been considered in details.
Analogy learning in Parkinson's disease: A proof-of-concept study
Authors: Jie Li-Juan , Goodwin Vicki , Kleynen Melanie , Braun Susy , Nunns Michael , Wilson Mark 
Published: March 2016

Background/Aims: Analogy learning is a motor learning strategy that uses biomechanical metaphors to chunk together explicit rules of a to-be-learned motor skill. This proof-of-concept study establishes the feasibility and potential benefits of analogy learning in enhancing stride length regulation in people with Parkinson's disease. Methods: Walking performance of thirteen individuals with Parkinson's disease was analysed using a Codamotion analysis system. An analogy instruction: ‘following footprints in the sand’ was practised over eight walking trials. Single- and dual-task (motor and cognitive) conditions were measured before training, immediately after training and 4 weeks post training. Finally, an evaluation form was completed to examine the intervention's feasibility. Findings: Data from 12 individuals (6 females and 6 males, mean age 70, Hoehn and Yahr grade I–III) were analysed; one person withdrew due to back problems. In the single-task condition, statistically and clinically relevant improvements were obtained. A positive trend towards reducing dual-task costs after the intervention was demonstrated, supporting the relatively implicit nature of the analogy. Participants reported that the analogy was simple to use and became easier over time. Conclusions: Analogy learning is a feasible and potentially implicit (i.e. reduced working memory demands) intervention to facilitate walking performance in people with Parkinson's disease.
A trajectory of relationship development for early intervention practice for children with developmental disabilities
Authors: Carroll Clare , Sixsmith Jane 
Published: March 2016

Background/Aims: Collaboration, through multiple complex relationships between families and professionals, is integral to early intervention practice for children with developmental disabilities. The purpose of this study was to explain the processes involved from the multiple perspectives of all those involved in the team. Methods: A grounded theory methodology was used. The sample included five young children with developmental disabilities, six parents and 17 professionals from an early intervention team. In total, 31 interviews were carried out. Through an iterative approach to data analysis, the processes of the early intervention relationship were explored. Results: The process of the early intervention relationship emerged from the data. The relationship process happens through an overlapping five stage developmental trajectory which includes: 1) initiating, 2) experimenting, 3) intensifying, 4) integrating and 5) transitioning. Conclusions: The role of relationships between professionals, children and their parents in successful early intervention disability services is paramount. The early intervention relationship is a complex interdependent one which requires a road map of explicit stages, which can facilitate all involved in the relationship to work together. This study provides this road map in the form of a developmental relationship trajectory. Understanding the key factors, within each stage of the developmental trajectory, supports positive relationships between professionals, children and their families, thus positively influencing the outcome of early intervention practice for children with developmental disabilities.
Insulin: An evolving paradigm in diabetes management
Authors: Meetoo Danny D 
Published: March 2016

Insulin therapy is vital for the treatment of type 1 diabetes, and is increasingly being used in type 2 diabetes. Danny D Meetoo describes the aims of insulin therapy and methods of insulin delivery The global incidence of diabetes mellitus has reached an alarming epidemic proportion. Of this large proportion, 5–10% are affected by type 1 diabetes while the remaining 90% have type 2 diabetes. Insulin therapy is vital in the former category, while this therapeutic mode is often included at a stage of the latter category to prevent respective hyperglycaemia and related micro and macrovascular complications. The modern prefilled and re-usable pen devices used as insulin delivery systems hold many advantages over the conventional approach, which was often associated with dosage errors. The ease and flexibility offered by pen devices into a busy lifestyle aims to improve diabetes management with much less effort and without affecting people's quality of life. Despite the promise of future developments in insulin delivery, serious consideration should always be given to cost implications in the management of diabetes.
Best practice in injection technique for diabetes
Authors: Diggle Jane 
Published: March 2016

Effective self-injection is key to optimal glycaemic control. Jane Diggle explains how practice nurses can help people with diabetes to prevent injection site problems through site rotation and avoiding the re-use of pen needles Best practice in injection technique is critical to ensuring optimal glycaemic control and is a part of good diabetes management. This article discusses the consequences of poor injection technique and offers advice on best practice in injection technique. A number of factors contribute to good technique, including injection site selection, injection site care, injection process, needle length, use of lifted skin folds (if appropriate) and rotation of injection sites. Health professionals also have a duty to teach and check an individual's injection technique, as well as to revisit and review their technique at subsequent consultations.
Savouring the Francophone Asia-Pacific: Métissage and Foodways in Ook Chung’s Kimchi and Jimmy Ly’s Bonbon sœurette et pai coco
Authors: Hiramatsu Ireland Benjamin 
Published: March 2016

Abstract
This article interrogates the neglected relationships between métissage, corporeality, memory and foodways within Francophone Asia-Pacific literatures written by Asiatic migrant writers of the French language. By focusing specifically on two texts, Ook Chung’s Kimchi (2001) and Jimmy Ly’s Bonbon soeurette et pai coco (1997), this study explores the various constructions of mixed-race, multiethnic diasporic identity through the intake and symbolism of food. Both multiethnic protagonists in these two texts exhibit sentiments of delocalization and otherness. However, through literal and epistemic acts of alimentary consumption that interlink with nostalgia, Chung’s and Ly’s protagonists structure individual and collective memories, while challenging certain intra-ethnic tensions and notions of hybridizing roots, language and cultural production.
‘Un roi en fuite: Le Mogho Naba Boukary Koutou pendant la pénétration française en pays mossi’
Authors: Simpore Karim 
Published: March 2016

Abstract
The year 1896 has remained engraved in the collective memory of the Mossi people. Indeed, this date has marked the forfeiture of the sovereignty of the emperor of the Mossi; the Mogho Naba Wobgo also called Boukary Koutou. The French colonial power has defeated and chased him out of his kingdom territory, thanks to the firepower that had been blown fiercely by Voulet Chanoine, one of the French brutal colonizers. Boukary Koutou knowing that he will not overcome these invaders, decided to run away, which can be considered as kind of ‘marronnage’ under the tropics, leaving behind him more questions than answers for his subjects. This unprecedented run away left wounds and stigmates that shook the Mossi collective core identity for which it is still yearning for healing and restoration. This article aims to depict the concept of identity myth and crises in conjunction with France conquest in Africa. Eliade, Jung and Kerenyi theories provide insights to understand the construction of the Mossi Identity myth through the findings of Guilhem et al., Kawada (2002), Hien and Salo. The objective of this article will be to witness the great impact of domination on collective identity evolution and perception.
Socrates, wake up! An analysis and exegesis of the “preface” in Plato’s Crito (43a1-b9)
Authors: Liebersohn Yosef Z. 
Published: March 2016

In this paper I offer a close analysis of the first scene in Plato’s Crito (43a1-b9). Understanding a Platonic dialogue as a philosophical drama turns apparent scene-setting into an integral and essential part of the philosophical discussion. The two apparently innocent questions Socrates asks at the beginning of the Crito anticipate Crito’s two problems, namely how he regards his friendship with Socrates as opposed to his complicated relations with the polis and its sovereignty. These two questions are an integral part of the philosophical discussion presented throughout the dialogue.

http://dx.doi.org/10.14195/2183-4105_15_2
Integration of Young People into the Latvian Labour Market
Authors: Grinevica Liva , Kovalevs Raimonds 
Published: March 2016

Abstract
The research deals with the question of how different resources affect the labour market integration of the long-term unemployed youth. The main hypothesis it advances is that the youth who have access to different resources will find more stable jobs or develop their own business after unemployment than those lacking such different kinds of support.
In making the education and employment decisions during the transition from school to work, there is strong evidence of the importance for young people to make good initial career decisions and an enduring effect of academic achievement on labour market and education outcomes.
This research is based on scientific discussion of different author opinions and survey results of young people as well as on views on the future vision of authors.
Place Matters: The Spatial Effects of Human Service Expenditures
Authors: Never Brent , Westberg Drew 
Published: March 2016

AbstractPlace matters in human services. Temporary Assistance for Needy Families (TANF) devolves spending to services, most often provided by nonprofit organizations. We argue that this devolution allows for people to “vote with their feet” (Ostrom, Tiebout, and Warren 1961: “The organization of government in metropolitan areas: A theoretical inquiry.”AmericanPolitical Science Review 55:831–42) in seeking jurisdictions where there will be more spending on human services. This paper considers the spatial patterns of human service expenditures, arguing that people of lower Socio-Economic Status (SES) are less likely to benefit from higher human service spending. We use a spatial Durbin regression to indicate the effects of SES on expenditures in a home county as well as the spillover effect to surrounding counties. The results show that while human service expenditures increase as African American and Renter populations increase in a home county, they also indicate that neighboring counties free-ride on the efforts of the home jurisdiction. Likewise, as a population ages, there is a very large free-riding effect. We conclude that the decentralized TANF policy regime allows for jurisdictions to specialize in human services.
Risk Analysis and Setting Priorities in Air Traffic Control by Using a Matrix of Similarities
Authors: Lacane Monta , Andersone Silva , Sestakovs Vladimirs 
Published: March 2016

Abstract
This article considers how mathematical decision-making in Air Traffic Control could be done in order to minimize the risk of collisions. An example of how to prioritize airplanes which are in the vicinity of an airport according to their level of risk in respect to other airplanes is given by using a matrix of similarities and Euclidean metric. The analysis has shown that it is necessary to classify ATC specialists and ATC centers according to their ability to provide safe enough service using time methods and highly experienced team work.