bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of using a wearable camera to record activity, participation and health-related behaviours: Qualitative reflections of using the Sensecam
Authors: Wilson Gemma , Jones Derek , Schofield Patricia , Martin Denis J. 
Published: July 2017

Objective Upcoming technology is changing the way that we are able to collect data looking into activity, social participation and health behaviours. Wearable cameras are one form of technology that allows us to automatically record a collection of passive images, building a visual diary of the user’s day. Whilst acknowledging the usefulness of wearable cameras in research, it is also important to understand individuals’ experiences whilst using them. The aim of this study was to explore the acceptance, experience and usability of a wearable camera (Microsoft® Sensecam) to record the day-to-day activity and social participation of older people. Methods A total of 18 older adults, who had worn the wearable camera for seven days, took part in semi-structured interviews. Results Four themes emerged from the findings: ‘Intrusiveness’; ‘Importance of others’; ‘Remembering the wearable camera’; and ‘Ease of use’. Conclusions Individuals’ expectations and experiences of using the wearable camera differed considerably. Participants believed that the wearable camera would be intrusive, difficult to use and would evoke public reaction; however, these worries were not borne out in experience. Individuals typically forgot about the presence of the wearable camera during use, remembering it only sporadically. One drawback to its use is that some participants were cautious of using the camera when around others, which impacted the amount of time the camera was worn, and, therefore, the nature of the data recorded. Design issues of the Sensecam were also a problem for the older adults in the study and affected their interaction with the technology.
The Effectiveness of Computer-Assisted Instruction to Teach Physical Examination to Students and Trainees in the Health Sciences Professions: A Systematic Review and Meta-Analysis
Authors: Tomesko Jennifer , Touger-Decker Riva , Dreker Margaret , Zelig Rena , Parrott James Scott 
Published: July 2017

Purpose: To explore knowledge and skill acquisition outcomes related to learning physical examination (PE) through computer-assisted instruction (CAI) compared with a face-to-face (F2F) approach. Method: A systematic literature review and meta-analysis published between January 2001 and December 2016 was conducted. Databases searched included Medline, Cochrane, CINAHL, ERIC, Ebsco, Scopus, and Web of Science. Studies were synthesized by study design, intervention, and outcomes. Statistical analyses included DerSimonian-Laird random-effects model. Results: In total, 7 studies were included in the review, and 5 in the meta-analysis. There were no statistically significant differences for knowledge (mean difference [MD] = 5.39, 95% confidence interval [CI]: −2.05 to 12.84) or skill acquisition (MD = 0.35, 95% CI: −5.30 to 6.01). Conclusions: The evidence does not suggest a strong consistent preference for either CAI or F2F instruction to teach students/trainees PE. Further research is needed to identify conditions which examine knowledge and skill acquisition outcomes that favor one mode of instruction over the other.
Microfinance and Poverty Reduction: Is Social Protection the Missing Link?
Authors: Priyadarshee Anurag 
Published: July 2017

An ever-increasing body of literature points out that microfinance, despite being widely acknowledged as an effective strategy for poverty reduction, is not reaching a majority of poor households and is, thus, not effective in reducing their poverty. Our current theoretical understanding indicates that this is largely due to demand deficit on the part of poor households for microfinance products and services currently on the offer. Such products and services are observed to be more suitable to the financial needs of richer poor than those of the poor and very poor households. Literature suggests that microfinance outreach to poor may be improved by altering their external environment or by modifying the microfinance products to suit the needs of the poor. Literature, however, largely overlooks recent developments in the arena of social protection that are impacting financial needs of the poor. On the basis of empirical findings from three Indian states, I argue that demand deficit for microfinance may be corrected if provisions of microfinance are built upon social protection programmes that are increasingly becoming a significant aspect of the financial environment of the poor. Empirical evidence suggests that financial services may be more useful and acceptable to the poor, and, thus, may have more potential to reduce poverty if they are linked with social protection programmes. In addition, the availability of financial services that substantially meet the needs generated by the social protection measures may also contribute towards deepening of the impact of such measures.
The First Compulsory Licencing Case in India under the TRIPS Agreement: An Analysis of Bayer Versus Natco Pharma Ltd
Authors: Raju K. D. 
Published: July 2017

Intellectual property rights provides protection to inventions and monopoly rights for a limited period of time to encourage innovation in industry. In many cases, it turned out to be an abuse of the monopoly power by different means. A compulsory licence is a mechanism provided under the Trade-related Aspects of Intellectual Property Rights (TRIPS) Agreement in order to revoke a patent granted to a patentee in certain circumstances. Across the world, the compulsory licencing (CL) on intellectual property rights (IPRs) is granted on similar grounds like unreasonably exorbitant prices of an essential facility or commodity, or in the country where patent does not work or where substantial public interest is affected by the way an IPR holder exercises his/her right. This article analyses India’s first CL order in favour of Natco Pharma which has garnered a lot of attention all over the world, and CL has been viewed as a remedy to curb the abuse of exclusivity protected by IPR. The case essentially revolves around an anti-cancer drug, Nexavar, which had been patented by Bayer. This article begins by elaborating the concept of CL and its effect on developing countries with a special reference to the TRIPS Agreement. The latter part would deal with the viability of CL order under the Indian framework of IP law and India‘s compliance with TRIPS in the background of the case of Bayer versus Natco Pharma. Finally, the article concludes that CL is a TRIPS-permitted provision that developing countries can use in their favour to protect their health sector, and the present case can be a model for the developing countries.
Leukofiltration plus pathogen reduction prevents alloimmune platelet refractoriness in a dog transfusion model
Authors: Slichter Sherrill J. , Pellham Esther , Bailey S. Lawrence , Christoffel Todd , Gettinger Irena , Gaur Lakshmi , Latchman Yvette , Nelson Karen , Bolgiano Doug 
Published: July 2017

Key PointsEight weekly transfusions of F-LR + pathogen-reduced donor platelets were accepted by 31 of 32 (97%) recipient dogs. Among accepting recipients, none developed lymphocyte and only 2 had platelet antibodies not associated with platelet refractoriness.
Characterisation of eppin function: expression and activity in the lung
Authors: Scott Aaron , Glasgow Arlene , Small Donna , Carlile Simon , McCrudden Maelíosa , McLean Denise , Brown Ryan , Doherty Declan , Lundy Fionnuala T. , Hamid Umar I. , O'Kane Cecilia M. , McAuley Daniel F. , Brodlie Malcolm , Tunney Michael , Elborn J. Stuart , Irwin Chris R. , Timson David J. , Taggart Clifford C. , Weldon Sinéad 
Published: July 2017

Eppin is a serine protease inhibitor expressed in male reproductive tissues.The aim of this study was to investigate the localisation and regulation of eppin expression in myeloid and epithelial cell lines, and explore its potential role as a multifunctional host defence protein.Using immunohistochemistry and Western blotting, eppin was detected in the lungs of patients with acute respiratory distress syndrome and cystic fibrosis lung disease. Expression of eppin in monocytic cells was unaffected by stimulation with Toll-like receptor agonists, cytokines and hormone receptor agonists. However, upregulated expression and secretion of eppin was observed following treatment of monocytes with epidermal growth factor. Incubation of recombinant eppin with monocytic cells resulted in significant inhibition of lipopolysaccharide-induced chemokine production. Furthermore, eppin inhibited lipopolysaccharide-induced NF-κB activation by a mechanism which involved accumulation of phosphorylated IκBα. In anin vivomodel of lung inflammation induced by lipopolysaccharide, eppin administration resulted in decreased recruitment of neutrophils to the lung with a concomitant reduction in the levels of the neutrophil chemokine macrophage inflammatory protein-2.Overall, these results suggest a role for eppin outside of the reproductive tract and that eppin may have a role in the innate immune response in the lung.
Tyk2 as a target for immune regulation in human viral/bacterial pneumonia
Authors: Berg Johanna , Zscheppang Katja , Fatykhova Diana , Tönnies Mario , Bauer Torsten T. , Schneider Paul , Neudecker Jens , Rückert Jens C. , Eggeling Stephan , Schimek Maria , Gruber Achim D. , Suttorp Norbert , Hippenstiel Stefan , Hocke Andreas C. 
Published: July 2017

The severity and lethality of influenza A virus (IAV) infections is frequently aggravated by secondary bacterial pneumonia. However, the mechanisms in human lung tissue that provoke this increase in fatality are unknown and therapeutic immune modulatory options are lacking.We established a human lungex vivoco-infection model to investigate innate immune related mechanisms contributing to the susceptibility of secondary pneumococcal pneumonia.We revealed that type I and III interferon (IFN) inhibitsStreptococcus pneumoniae-induced interleukin (IL)-1β release. The lack of IL-1β resulted in the repression of bacterially induced granulocyte-macrophage colony-stimulating factor (GM-CSF) liberation. Specific inhibition of IFN receptor I and III-associated tyrosine kinase 2 (Tyk2) completely restored theS. pneumoniae-induced IL-1β–GM-CSF axis, leading to a reduction of bacterial growth. A preceding IAV infection of the human alveolus leads to a type I and III IFN-dependent blockade of the early cytokines IL-1β and GM-CSF, which are key for orchestrating an adequate innate immune response against bacteria. Their virally induced suppression may result in impaired bacterial clearance and alveolar repair.Pharmacological inhibition of Tyk2 might be a new treatment option to sustain beneficial endogenous GM-CSF levels in IAV-associated secondary bacterial pneumonia.
Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine
Authors: Harris Gerd-Marie Eskerud , Wood Mollie , Eberhard-Gran Malin , Lundqvist Christofer , Nordeng Hedvig 
Published: July 2017

AbstractBackgroundFew studies have investigated the drug utilization patterns and factors predicting drug use in pregnant women with migraine. This longitudinal drug utilization study aimed to describe patterns of analgesic use in a sample of Norwegian pregnant women according to their migraine history, and to identify predictors for analgesic use among these women.MethodsPregnant women giving birth at Akershus University Hospital between 2008 and 2010 were recruited at ultrasound examination in gestational week 17. Data were collected by questionnaires in gestational weeks 17 and 32, and at 8 weeks postpartum, and linked to birth records. Women were grouped into four categories according to migraine history: no migraine history, previous migraine history, recent migraine history (within 1 year prior to pregnancy) and migraine in pregnancy. Patterns of use of analgesics were analyzed descriptively. Multivariable logistic regression was used to identify factors predicting analgesic use.ResultsOut of 1981 women, 5.0% reported having migraine in pregnancy, 13.2% had a recent history of migraine, 11.5% had a previous history of migraine, and 68.8% reported no history of migraine. Analgesic use declined during pregnancy. Many women switched from triptans and non-steroidal anti-inflammatory drugs to paracetamol, which constituted most of the analgesic use. Factors associated with analgesic use included recent migraine history (OR 1.6, 95% CI 1.2–2.2), more severe headache intensity (OR 1.3, 95% CI 1.3–1.4), smoking (OR 1.9, 95% CI 1.1–3.3) and multiparity (OR 1.4, 95% CI 1.1–1.7).ConclusionsWomen with migraine stop or switch medications during pregnancy. Analgesic use in pregnancy is affected by migraine characteristics and intensity, and also by socio-demographic factors. Clinicians should bear this in mind when giving advice on adequate management of migraine in pregnancy and safe analgesic use.
A semi-automated approach to generate 4D/5D BIM models for evaluating different offshore oil and gas platform decommissioning options
Authors: Cheng Jack C. P. , Tan Yi , Song Yongze , Liu Xin , Wang Xiangyu 
Published: July 2017

Abstract
Background
Offshore oil and gas platforms generally have a lifetime of 30 to 40 years, and platform decommissioning is a major issue because many of the existing offshore oil and gas platforms are reaching the end of their service life. There are many possible options for decommissioning offshore oil and gas platforms, and each decommissioning option can be implemented using different methods and technologies. Therefore, it is necessary to have a clear understanding and in-depth evaluation of each decommissioning option before commencing platform decommissioning. 4D and 5D building information modeling (BIM) has been commonly used in the building industry to analyze constructability and to evaluate different construction or demolition plans. However, application of BIM in the oil and gas industry, especially for the platform decommissioning process, is still limited.

Methods
This paper suggests and demonstrates the application of 4D and 5D BIM technology to simulate various methodologies to realize various selected offshore platform decommissioning options, thereby visualizing and evaluating different options, considering both the time and resources required for decommissioning process. One hundred and seventy-seven offshore platform decommissioning options are summarized in this paper. A new approach to create multiple 4D/5D BIM models in a semi-automated manner for evaluating various scenario options of OOGP decommissioning was proposed to reduce the model creation time as current way of 4D/5D BIM model creation for each OOGP decommissioning option is time consuming.

Results
In the proposed approach, an OOGP BIM model relationship database that contains possible 4D/5D BIM model relationships (i.e. schedules for different decommissioning methods) for different parts of an OOGP was generated. Different OOGP decommissioning options can be simulated and visualized with 4D/5D BIM models created by automatically matching schedules, resources, cost information and 3D BIM models. This paper also presents an illustrative example of the proposed approach, which simulates and evaluates two decommissioning options of a fixed jacket platform, namely Rig-to-Reef and Removal-to-Shore. As compared to the traditional approach of 4D/5D BIM model generation, the proposed semi-automated approach reduces the model generation time by 58.8% in the illustrative example.

Conclusions
The proposed approach of semi-automated 4D/5D BIM model creation can help understand the implication of different decommissioning options as well as applied methods, detecting potential lifting clashes, and reducing 4D/5D BIM model creation time, leading to better planning and execution for the decommissioning of offshore oil and gas platforms. In addition, with the proposed semi-automated approach, the 4D/5D BIM model can be generated in a more efficient manner.
Implementing the Quality Startup Management System model in Hong Kong: a case study
Authors: LAI Kim-Hung Lotto 
Published: July 2017

AbstractThe innovation and technology industries have become key areas to which the HKSAR Government is committed for advanced technology development and new economic driven. In order to nurture and support local technology startups grow and flourish successfully, HKSTP had signed a memorandum of understanding (MOU) with Hong Kong Quality Assurance Agency (HKQAA) to support incubation programmes through business matching and quality assurance mechanisms for startup companies. Hong Kong Society for Quality (HKSQ) was invited by HKQAA to be one of members in the advisory committee for this recognition scheme. Then, focus group was formed from different parties, including but not limited to incubatees, incubators, investors, HKSTP, HKQAA, HKSQ and other concerned stakeholders. This paper aims to introduce a systematic approach model named “Quality Startup Management System (QStarMS) Model” through literature review and analysis, focus group and case study. QStarMS integrated Business Side of startup using Business Model Generation/Canvas (BMG/C) and Management Side under ISO 9001:2015 Quality Management System, as well as, to simplify the model to fit startups requirements and overcome their limitations. Finally, we will report the recently progress of the QStarMS implementation through HKQAA Registration – Startups scheme.
Effect of sedimentary environment on shale lithofacies in the lower third member of the Shahejie Formation, Zhanhua Sag, eastern China
Authors: Li Tingwei , Jiang Zhenxue , Xu Chenlu , Yuan Yuan , Wang Pengfei , Liu Guoheng , Zhang Bo , Ning Chuanxiang , Wang Zhi 
Published: July 2017

Research on shale lithofacies is important for shale oil and gas production. This study focused on the lower third member of the Shahejie Formation ([Formula: see text]) in the Luo-69 well in the Zhanhua Sag, Jiyang Depression, Bohai Bay Basin, eastern China. Several methods, including thin section observations, total organic carbon (TOC) analysis, X-ray diffraction analysis, quantitative evaluations of minerals by scanning electron microscopy, major and trace-element analyses, and field emission-scanning electron microscopy, are used to investigate the effect of sedimentary environment on the type and distribution of shale lithofacies. Our research indicates that 36 types of shale lithofacies can be classified based on the TOC content, mineral composition, and sedimentary structure, of which five types are identified in the study area. The [Formula: see text] shale has a high calcareous mineral content (average of 49.64%), low clay and siliceous minerals contents (averages of 19.54% and 19.02%, respectively), a high TOC content (average of 3.00 wt%), and well-developed horizontal bedding. The sedimentary environment during the deposition of the [Formula: see text] shale in the Zhanhua Sag had a warm and moist climate, limited provenance, saline water, and strong reducibility. The sedimentary environment in the early stage had a drier climate, more limited provenance, higher salinity, and stronger reducibility than that in the later stage. Shale lithofacies can reflect a certain sedimentary environment and depositional process; similarly, a depositional environment controls the type and distribution of shale lithofacies. Due to the characteristics of the [Formula: see text] sedimentary environment, organic-rich massive mixed shale, organic-rich bedded mixed-calcareous shale, organic-rich laminated calcareous shale, and organic-fair laminated calcareous shale are developed in the [Formula: see text] formation from top to bottom.
Use of Bisphosphonates and Risk of Breast Cancer in a French Cohort of Postmenopausal Women
Authors: Fournier Agnès , Mesrine Sylvie , Gelot Amandine , Fagherazzi Guy , Baglietto Laura , Clavel-Chapelon Françoise , Boutron-Ruault Marie-Christine , Chabbert-Buffet Nathalie 
Published: July 2017

Purpose To assess whether bisphosphonate (BP) use is associated with decreased breast cancer incidence in a cohort of postmenopausal women. Methods The study population included 64,438 postmenopausal women participating in the French E3N (Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale) prospective cohort, with data self-reported in biennial questionnaires matched with data from a drug reimbursement database. Exposure to BPs and the use of other osteoporosis treatments during follow-up were determined using reimbursement data. Other covariates (breast cancer risk factors, clinical risk factors for osteoporotic fractures, and bone mineral density surveillance) originated from the questionnaires. Hazard ratios (HRs) of breast cancer were estimated using Cox proportional hazards models, considering exposure as a time-varying variable. Results Over an average of 7.2 years of follow-up (2004 to 2011), 2,407 first primary breast cancer cases were identified. The HR of breast cancer associated with exposure to BPs was 0.98 (95% CI, 0.85 to 1.12). We found no effect modification by age, body mass index, time since menopause, use of hormone replacement therapy, use of calcium supplements, or use of vitamin D supplements. There was no heterogeneity across BP molecules and no trend according to cumulative dose, duration of use, or time since last use. We observed a decrease in breast cancer risk restricted to the year after treatment initiation (HR, 0.56; 95% CI, 0.36 to 0.87), which was likely explained by healthy screenee bias. Finally, we did not find any variation in HRs across breast carcinomas defined by their estrogen receptor or invasive or in situ status. Conclusion In our observational cohort of postmenopausal women observed from 2004 to 2011, BP use, likely prescribed for the management of osteoporosis, was not associated with decreased breast cancer incidence.