bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Utility of HCV Core Antigen Detection and Quantification in the Diagnosis and Management of Patients with Chronic Hepatitis C Receiving an All-Oral, Interferon-Free Regimen
Authors: Chevaliez Stéphane , Feld Jordan , Cheng Kevin , Wedemeyer Heiner , Sarrazin Christoph , Maasoumy Benjamin , Herman Christine , Hackett John , Cohen Daniel , Dawson George , Pawlotsky Jean-Michel , Cloherty Gavin 
Published: April 2016

Background The introduction of highly potent direct-acting combination therapies for HCV have negated the role of response-guided therapy and reduced the role of treatment monitoring. However, there remains a need to identify patients who are actively infected with HCV and discriminate those who have achieved sustained virological response (SVR) from those who fail to achieve SVR. Methods A total of 1,678 plasma samples from the 631 subjects enrolled in AbbVie's SAPPHIRE I trial (NCT01716585) were tested in a blinded fashion with Abbott HCV core antigen (cAg) assay and results were compared with Roche High-Pure system/COBAS® TaqMan HCV RNA 2.0 assay. Results Using 10 fmol/l as the clinical cutoff for cAg, the HCV RNA and cAg tests were in 100% agreement for true negative samples and 99.6% agreement for truly positive samples. One discordant (screening) sample was identified. This sample was target not detected by HCV RNA method but positive by anti-HCV and highly positive by ARCHITECT core antigen (7,912 fmol/l). Seventeen samples had cAg levels in the ‘grey zone’ >3 but <10 fmol/l at initial testing and were re-tested per package insert. All of these samples gave a result of <3 fmol/l upon retest. These results were in alignment with target not detected HCV RNA result. One sample had a cAg >3 but <10 fmol/l when tested on three consecutive occasions (5.8, 5.5 and 4.4) but had a target not detected RNA result. Conclusions In this study cAg, with a 10 fmol/l cutoff, accurately identified 99.6% of patients with active viraemia and discriminated all subjects who achieved SVR from those who failed therapy.
Normes financières et modèle économique :
Authors: Barneto Pascal , Degos Jean-Guy , Ouvrard Stéphane 
Published: April 2016

La notion de business model apparaît de manière explicite dans la norme IFRS 9 et de manière implicite dans le cadre conceptuel, version 2010 de l’IASB. Néanmoins, la notion de business model reste utilisée avec précaution par l’organisme normalisateur afin d’éviter les abus de la comptabilité d’intention (P. Danjou, 2013). Il semble en effet qu’il y ait une réelle difficulté à concilier l’idéal de neutralité avec la demande d’une information financière permettant de « voir l’entreprise à travers les yeux du management » (G. Gélard, 2008). La question de la représentation fidèle des phénomènes économiques implique que l’information soit complète, neutre et sans erreur. La question du lien entre business model et comptabilité financière semble aujourd’hui faire débat.
La qualité de l’audit légal en Afrique francophone :
Authors: Causse Geneviève , Ebondo Wa Mandzila Eustache 
Published: April 2016

L’audit légal est une activité d’intérêt général dont la qualité dépend essentiellement des contrôles exercés sur la profession. L’objectif de notre article est de faire un état des lieux des cadres institutionnels de l’audit légal prévalant dans les pays d’Afrique francophone que l’on rattache à « l’École française de comptabilité ». L’analyse des textes réglementaires et professionnels, ainsi qu’une enquête auprès des professionnels permettent d’affirmer que la profession est partout réglementée et contrôlée mais à des degrés assez divers. Elle est relativement peu développée dans la zone géographique étudiée. Le constat effectué conduit aux questions suivantes : le développement et la qualité de l’audit ne seraient-ils pas contingents du niveau de développement économique et des caractéristiques culturelles du pays considéré ? Peut-on échapper à la pression de la normalisation internationale et envisager un profil d’auditeur adapté au contexte économique et social ? L’objectif de notre communication est également de tenter de répondre à ces interrogations.
Expertise comptable en Tunisie :
Authors: Khlif Wafa , El Omari Sami 
Published: April 2016

L’objectif de cet article est d’explorer les conditions sociales de création de la profession des experts-comptables tunisiens ainsi que de comprendre les enjeux de ses batailles territoriales. Au niveau théorique, nous avons combiné l’approche néo-Weberienne avec celle d’A. Abbott. Au niveau empirique, nous nous sommes basés sur des sources primaires complétées par une enquête quantitative ainsi que des entretiens semi-directifs. Trois principaux résultats sont retenus : 1. le rôle central de l’État dans l’évolution de la profession, 2. la persistance postcoloniale de l’influence du modèle français et 3. le mouvement continu des frontières professionnelles des experts- comptables.
De l’autre côté du périph’ :
Authors: Tixier Julie , Notais Amélie 
Published: April 2016

Cet article s’attache aux cas de 6 femmes entrepreneures sociales dans les quartiers. Sur la base de leurs récits de vie, recueillis au cours d’une formation dédiée à l’entrepreneuriat social au cœur de la cité des 4000 de la Courneuve, la problématique suivante est investie : dans quelle mesure le projet d’entrepreneuriat social révèle-t-il une construction identitaire pour les femmes des quartiers ? Ces six femmes, dans leur complexité et la diversité de leur parcours, exposent une construction identitaire, en périphérie du cadre. Elles proposent un « devenir-entrepreneure » au sens de G. Deleuze et F. Guattari (1980). Enfin, une démarche réflexive des chercheures questionne un « devenir-chercheure » autrement. This research focuses on six female social entrepreneurs in deprived areas. Their life stories were collected during a specific training session on social entrepreneurship in the city of la Courneuve. The research question is the following: to what extent the social entrepreneurship project is the revelator of an identity construction for women in deprived areas? The cases of six women in their complexity and background diversity expose an identity construction following a peripheral process. Those women propose a « becoming entrepreneure » in the sense of G. Deleuze and F. Guattari (1980). Finally, the researchers’ reflective approach leads them towards questioning a differently « becoming-researcher ».
The Flipped Learning Approach in Nursing Education: A Literature Review
Authors: Presti Carmen Rosa 
Published: April 2016

Background:
This integrative review examines the application of the pedagogical methodology—the flipped classroom—in nursing education.

Method:

A literature search of the CINAHL, ERIC, and the National Library of Medicine (PubMed and MEDLINE) databases was conducted, using the following key words:
flipped classroom
,
inverted classroom
, and
nursing education
.

Results:
Results of a literature search yielded 94 articles, with 13 meeting the criteria of the flipped classroom approach in nursing education. Themes identified include the theoretical underpinning, strategies for implementation of a flipped classroom, and student satisfaction with and outcomes of the flipped classroom approach.

Conclusion:

Syntheses of the findings indicate that the flipped classroom approach can yield positive outcomes, but further study of this methodology is needed to guide future implementation. [
J Nurs Educ.
2016;55(5):252–257.]
Teaching Nursing Students the Importance of Treatment Fidelity in Intervention Research: Students as Interventionists
Authors: Eymard Amanda S. , Altmiller Gerry 
Published: April 2016

Background:
Treatment fidelity is the extent to which a study team adheres to the dictates of a study protocol. It ensures that the intervention has been implemented as intended. Including and monitoring treatment fidelity reduces threats to validity and is vital to providing reputable, sound research.

Method:
This article describes specific measures taken to teach nursing students the key concepts and methodologic issues associated with treatment fidelity in intervention research studies through active learning. Twelve senior-level nursing students participated as interventionists in a study that spanned 4 months.

Results:
Treatment fidelity strategies included development of a manual, proper training and supervision of interventionists, a follow-up meeting with the interventionists, checklists, and a controller.

Conclusion:

The treatment fidelity strategies implemented throughout the study provided an opportunity for students to learn firsthand how such strategies are implemented and how they strengthened the confidence that study findings are indeed related to the intervention. [
J Nurs Educ.
2016;55(5):288–291.]
IDO2 Modulates T Cell–Dependent Autoimmune Responses through a B Cell–Intrinsic Mechanism
Authors: Merlo Lauren M. F. , DuHadaway James B. , Grabler Samantha , Prendergast George C. , Muller Alexander J. , Mandik-Nayak Laura 
Published: April 2016

Abstract
Mechanistic insight into how adaptive immune responses are modified along the self–nonself continuum may offer more effective opportunities to treat autoimmune disease, cancer, and other sterile inflammatory disorders. Recent genetic studies in the KRN mouse model of rheumatoid arthritis demonstrate that the immunomodulatory molecule IDO2 modifies responses to self-antigens; however, the mechanisms involved are obscure. In this study, we show that IDO2 exerts a critical function in B cells to support the generation of autoimmunity. In experiments with IDO2-deficient mice, adoptive transplant experiments demonstrated that IDO2 expression in B cells was both necessary and sufficient to support robust arthritis development. IDO2 function in B cells was contingent on a cognate, Ag-specific interaction to exert its immunomodulatory effects on arthritis development. We confirmed a similar requirement in an established model of contact hypersensitivity, in which IDO2-expressing B cells are required for a robust inflammatory response. Mechanistic investigations showed that IDO2-deficient B cells lacked the ability to upregulate the costimulatory marker CD40, suggesting IDO2 acts at the T–B cell interface to modulate the potency of T cell help needed to promote autoantibody production. Overall, our findings revealed that IDO2 expression by B cells modulates autoimmune responses by supporting the cross talk between autoreactive T and B cells.
Cultural Respect Encompassing Simulation Training: Being Heard about Health through Broadband
Authors: Min-Yu Lau Phyllis , Woodward-Kron Robyn , Livesay Karen , Elliott Kristine , Nicholson Patricia 
Published: April 2016

Background Cultural Respect Encompassing Simulation Training (CREST) is a learning program that uses simulation to provide health professional students and practitioners with strategies to communicate sensitively with culturally and linguistically diverse (CALD) patients. It consists of training modules with a cultural competency evaluation framework and CALD simulated patients to interact with trainees in immersive simulation scenarios. The aim of this study was to test the feasibility of expanding the delivery of CREST to rural Australia using live video streaming; and to investigate the fidelity of cultural sensitivity – defined within the process of cultural competency which includes awareness, knowledge, skills, encounters and desire – of the streamed simulations. Design and Methods In this mixed-methods evaluative study, health professional trainees were recruited at three rural academic campuses and one rural hospital to pilot CREST sessions via live video streaming and simulation from the city campus in 2014. Cultural competency, teaching and learning evaluations were conducted. Results Forty-five participants rated 26 reliable items before and after each session and reported statistically significant improvement in 4 of 5 cultural competency domains, particularly in cultural skills (P<0.05). Qualitative data indicated an overall acknowledgement amongst participants of the importance of communication training and the quality of the simulation training provided remotely by CREST. Conclusions Cultural sensitivity education using live video-streaming and simulation can contribute to health professionals’ learning and is effective in improving cultural competency. CREST has the potential to be embedded within health professional curricula across Australian universities to address issues of health inequalities arising from a lack of cultural sensitivity training.
Health Professional Workforce Education in the Asia Pacific
Authors: Lees Jessica , Webb Gillian , Coulston Frances , Smart Aidan , Remedios Louisa 
Published: April 2016

Objective To design and implement an international and interprofessional Global Learning Partnership Model, which involves shared learning between academics and students from Universitas 21 network with other universities with United Nations Millennium Development Goal needs. Design Two literature reviews were conducted to inform ethical aspects and curriculum design of the GLP model. Feedback from conference presentations and consultation with experts in education and public health has been incorporated to inform the current iteration of the GLP model. Intervention The pilot group of 25 students from U21 universities and Kathmandu University, representing six health disciplines will meet in Nepal in April 2016 for a shared learning experience, including a one week university based workshop and three week community based experience. Outcome measures A multi-phase, mixed method design was selected for the evaluation of the GLP model, utilising a combination of focus groups and questionnaires to evaluate the efficacy of the placement through student experience and learning outcomes in cultural competency, UN SDG knowledge, community engagement and health promotion skills. Results The literature review demonstrated that cultural awareness and cultural knowledge were improved through participation in cultural immersion programs that incorporated preparatory workshops and clinical experiences. Data will be gathered in April 2006 and the results of the evaluation will be published in the future. Conclusions The GLP model proposes a project around the fundamental concept of engagement and sharing between students and academics across universities and cultural contexts to build capacity through education, while capitalising on strengths of existing global health placements. Further the inclusion of host-country students and academics in this learning exchange will promote the establishment of an international and interprofessional network for ongoing health promotion.
A Community Engaged Dental Curriculum: A Rural Indigenous Outplacement Programme
Authors: Abuzar Menaka A. , Owen Julie 
Published: April 2016

Background Indigenous people worldwide suffer from poor oral health as compared to non-Indigenous citizens. One of the approaches to bring about improvement in Indigenous oral health is to enhance the service provision by implementing oral health outplacement programmes. A case study of such a programme for dental students in Australia reports how an educational institution can successfully engage with an Indigenous oral health service to provide learning experiences to the students as well as deliver much needed services to the community. Design and Methods The assessment of this ongoing outplacement programme over the period of 2008-14, based on students’ feedback, highlights some of the key beneficial outcomes. Students agreed that the Indigenous outplacement programme improved their understanding of Indigenous issues (mean ± SD: 4.10±0.8; 5 refers to strongly agree on 5-point scale) and increased the possibility that they will practise in Indigenous health (3.66±1.0). They were pleased with the assistance received by clinical supervisors and clinic staff at the Indigenous dental clinic (4.28±0.8). Conclusions This programme has demonstrated that structured student outplacements are valuable in building relations across cultures especially with Indigenous communities. It has also shown that university engagement with the public health sector can be beneficial to both institutions.
Evaluation of the effect of three supplementary oral hygiene measures on salivary mutans streptococci levels in children: A randomized comparative clinical trial
Authors: Manju M. , Prathyusha P. , Joseph Elizabeth , Kaul Rupali Borkar , Shanthraj Srinivas L. , Sethi Ntasha 
Published: April 2016

ABSTRACT
Objective: The aim of this study was to evaluate and compare the effect of tongue scraping, tongue brushing, and saturated saline on salivary MS levels. Materials and Methods: A single-blinded, randomized, parallel group clinical trial was conducted in children aged 9–12 years. Total sample of 45 subjects were randomly assigned to three groups, that is, Group A, Group B, and Group C comprised of 15 each. Group A, Group B, and Group C were asked to do tongue scraping, tongue brushing and saturated saline rinsing twice daily, respectively for 21 days. Saliva samples, collected from the subjects on the baseline, 7th day and 21st day, were inoculated on mitis salivarius bacitracin agar and incubated at 37°C for 48 h. The mean streptococcal colony forming counts were enumerated. The data were subjected to statistical analysis using Wilcoxon signed rank sum test for intragroup comparisons and Mann–Whitney U-test for intergroup comparisons. Results: Intragroup comparisons showed statistically significant reduction in MS levels (P < 0.01). However, the intergroup comparisons showed no statistically significant difference (P > 0.05). Conclusion: The oral hygiene measures evaluated proved equal efficacy in reducing the colony counts. Hence, there is a need to emphasize the importance of incorporating supplementary oral hygiene measures in daily oral care.
Localized idiopathic root resorption in the primary dentition: Review of the literature and a case report
Authors: Nasehi Atefeh , Mazhari Fatemeh , Mohtasham Nooshin 
Published: April 2016

ABSTRACTIdiopathic root resorption (IRR) is an infrequent condition that is usually found as an accidental finding on radiography. A significant number of cases of IRR in permanent dentition have been presented but are rarely reported in primary dentition. The aim of this case report is to present a case of localized IRR in a 7-year-old boy. The patient was referred because of increased mobility of the left mandibular primary second molar. On radiographic evaluation, severe root resorption of that tooth, and mild root resorption of the right mandibular primary second molar were evident; the patient was caries-free. The left affected tooth was lost, and after placing a band and loop space maintainer, the patient was followed for 18 months. A patient with an abnormal pattern of root resorption, especially in the primary dentition, should alert the clinician to rule out the known important local and systemic factors. The exact causes of and treatments for IRR continue to be discovered.
Follicular Carcinoma of Thyroid Metastasizing to the Sphenoid Sinus
Authors: Radhakrishnan Suma R , Andru Asjeena 
Published: April 2016

ABSTRACTIntroductionMetastatic tumors to the nose and paranasal sinuses are unusual with 167 cases published in the literature since 1951. The most common locations of the primary tumors are renal, lung, breast, testis, gastrointestinal tract and thyroid gland. There are only 26 documented cases of metastasis to the sphenoid sinus of which only six are from follicular carcinoma thyroid.Materials and methodsCase reports of two patients referred to our department with ocular symptoms having a final diagnosis of follicular carcinoma thyroid with sphenoid sinus metastasis were studied and literature review done.DiscussionMetastasis to the sphenoid sinus from follicular carcinoma thyroid is a rare entity and here we present two more cases of which one was an occult thyroid carcinoma. Both patients presented with ocular symptoms and the features of metastasis was the first sign of disease.ConclusionEarly diagnosis of signs and symptoms relating to metastatic sphenoid disease is necessary as these are frequently the first presentation of malignancy. Even though cure of patients with sphenoid sinus metastasis has not been reported, palliation with resolution of morbidity is possible.How to cite this articleRadhakrishnan SR, Andru A, Peetta-kkandy V. Follicular Carcinoma of Thyroid Metastasizing to the Sphenoid Sinus. Clin Rhinol An Int J 2015;8(2):53-57.
Sinonasal Undifferentiated Carcinoma: A Case Report and Review of Literature
Authors: Chitguppi Chandala 
Published: April 2016

ABSTRACT
Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor of the nasal cavity and paranasal sinuses. It can be differentiated from other neoplasms by correlating clinical, light microscopic, immunohistochemical and ultrastructural characteristics. Due to the small number of reported cases, the ideal treatment regimen has not been systematically evaluated. The treatment of SNUC includes aggressive multimodality therapy, including surgical resection and adjuvant treatment (i.e. radiotherapy, chemotherapy) because of high rate of both loco-regional recurrence and distant metastasis.

How to cite this article
Rajan S, Raj A, Chauhan A, Rathore PK, Wadhwa V, Khurana N, Chitguppi C. Sinonasal Undifferentiated Carcinoma: A Case Report and Review of Literature. Clin Rhinol An Int J 2015;8(2):60-63.
Endonasal Endoscopic Approach for Skull Base Neurofibroma: Is It Viable?
Authors: Chauhan Neha , Tiwari MK , Kim Vaiphei 
Published: April 2016

ABSTRACT
Anterior skull base and sinonasal schwannomas are rare entities. Earlier, safest way to remove these tumors, with best success rates, was open craniofacial surgery but recently with introduction of endoscopic endonasal approach; complete resection of these rare entities is possible. We present one such case of skull base neurofibroma which was resected in entirety via a purely endoscopic endonasal approach.

How to cite this article
Gupta A, Tiwari MK, Chauhan N, Kaur N, Kim V. Endonasal Endoscopic Approach for Skull Base Neurofibroma: Is It Viable?. Clin Rhinol An Int J 2015;8(2):72-75.
Pediatric Lobular Capillary Hemangioma Nasal Cavity
Authors: Varshney Saurabh , Gairola Priyanka , Malhotra Manu 
Published: April 2016

ABSTRACT
A lobular capillary hemangioma (LCH) is a benign uncommon entity of unknown etiology among vascular lesions of the head and neck. Although it has no predilection for age, it is more common in the third decade and in females. Lobular capillary hemangioma usually involves the gingiva, lips, tongue and buccal mucosa. The nasal cavity is a rare location. The most common symptoms are nasal obstruction and epistaxis. The treatment is nasal endoscopic surgery.
We review these vascular lesions and present the clinical features, radiological findings, treatment performed and histopathological results of two cases of LCH originating in the left inferior turbinate and septum. No recurrence was observed after complete endoscopic resection during 6 months follow-up. Lobular capillary hemangioma should be taken into consideration among the differential diagnosis of a painless hemorrhagic endonasal mass even though it is a rare entity. If complete resection is performed, prognosis is excellent and the recurrence rate is low.

How to cite this article
Varshney S, Malhotra M, Kaur N, Gairola P. Pediatric Lobular Capillary Hemangioma Nasal Cavity. Clin Rhinol An Int J 2015;8(2):76-80.