bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health and welfare profile of Australian baby boomers who live in rented accommodation – implications for the future
Authors: TAYLOR ANNE W. , PILKINGTON RHIANNON , DAL GRANDE ELEONORA , KOURBELIS CONSTANCE , BARRY HELEN 
Published: October 2017

ABSTRACTBaby boomers who rent are often overlooked as an important sub-group. We aimed to assess the chronic conditions, risk factors, socio-economic factors and other health-related factors associated with renting in private or public housing. Data from telephone interviews conducted each month in South Australia between 2010 and 2015 were combined. Prevalence estimates were assessed for each risk factor and chronic condition by housing status. The association between housing status and variables of interest were analysed using logistic regression models adjusting for multiple covariates (age, gender, income, smoking, physical activity, area and year of data collection). Overall, 17.4 per cent of the 16,687 baby boomers interviewed were renting, either privately or using government-subsided housing. The health profile of renters (both private and public) was poorer overall, with renters more likely to have all of the chronic conditions and ten risk factors assessed. For public renters the relationships were maintained even after controlling for socio-economic and risk factor variables for all chronic diseases except osteoporosis. This research has provided empirical evidence of the considerable differences in health, socio-economic indicators and risk factors between baby boomers who rent and those who own, or are buying, their own homes.
Emission properties of suprathermal electrons produced by laser–plasma interactions
Authors: Liu Huiya , Kang Ning , Zhou Shenlei , An Honghai , Fang Zhiheng , Xiong Jun , Li Kun , Lei Anle , Lin Zunqi 
Published: October 2017

AbstractSuprathermal electrons produced by laser–plasma interactions at 0.53-μm laser wavelength have been investigated using 19 electron spectrometers. The targets were 2- and 10-μm-thick Al foils, while the laser average intensities were 2 × 1013 and 7 × 1014 W/cm2. A double temperature distribution was observed in the electron energy spectrum: the lower electron temperature was below 25 keV, whereas the higher was ~50 keV. The angular distribution of the total suprathermal electron energy approximately obeyed the Gaussian distribution, peaking along the k vector of the incident laser beam for perpendicular incidence. Furthermore, the conversion rate of laser energy into escaped suprathermal electron energy over the π sr solid angle was ~10−4 at $\sim \!\!10^{14} \; {\rm W}/{\rm c}{\rm m}^{\rm 2}$, increasing almost linearly with the laser intensity.
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats
Authors: Zheng Qin , Li Yulin , Zhang Dandan , Cui Xinyuan , Dai Kuixing , Yang Yu , Liu Shuai , Tan Jichun , Yan Qiu 
Published: October 2017

AbstractPolycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by polycystic ovaries, hyperandrogenism and anovulation. It is one of the main causes of infertility. RU486 is an antagonist of progesterone receptor, and most commonly used as a contraceptive. However, whether RU486 is correlated with PCOS remains unclear. Atrial natriuretic peptide (ANP) is a small peptide with natriuretic and diuretic functions, and its availability to be used in PCOS treatment is unknown. Here, we showed that the serum ANP level was lower in PCOS patients than that in healthy women, and it was also decreased in the serum and ovarian tissues of RU486-induced PCOS rats compared with the control rats. We also found that RU486 inhibited the proliferation and promoted the apoptosis of human KGN ovarian granulosa cells by downregulating progesterone receptor membrane component 1 (PGRMC1). Meantime, ANP promoted the proliferation and inhibited the apoptosis of KGN cells through upregulating ANP receptor A (NPRA). The promotive effects of ANP on ovarian functions were mediated through the formation of an NPRA/PGRMC1/EGFR complex, which further activated MAPK/ERK signaling and transcription factor AP1. Moreover, ANP treatment reversed the PCOS symptoms, and improved the fertility of RU486-induced PCOS rats. Collectively, these findings highlight that RU486 is associated with the pathogenesis of PCOS, and ANP treatment may be a promising therapeutic option for PCOS.
iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer
Authors: Xue Yijun , Han Haibo , Wu Lina , Pan Bo , Dong Bin , Yin C Cameron , Tian Zhihua , Liu Xijuan , Yang Yue , Zhang Hong , Chen Yingyu , Chen Jinfeng 
Published: October 2017

AbstractAutophagy serves a critical function in the pathogenesis, response to therapy and clinical outcome in cancers. Although a recent report showed a role of iASPP in suppressing autophagy, its potential activity as a regulator of autophagy has not been investigated in lung cancer. Here we investigated the potential function and molecular mechanism of iASPP in mediating autophagy in human non-small-cell lung cancer. Our data suggested that forced expression of iASPP triggered autophagic flux, while inhibition of iASPP suppressed autophagy at the autophagsome formation stage in vitro. Furthermore, in vivo overexpression of iASPP in SCID/NOD mice promoted tumorigenesis and autophagy, with an increase in the conversion from LC3-I to LC3-II. The effects of iASPP were mediated through activation of mTOR pathway. Finally, cytoplasmic iASPP expression was upregulated in lung cancer patients, and was identified as an independent poor prognostic factor for lung cancer-specific death in patient samples. Taken together, our data showed that iASPP could promote tumor growth by increasing autophagic flux, and iASPP could serve as a poor prognostic factor and a potential therapeutic target in lung cancer.
Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78
Authors: Fang Shuhuan , Hong Honghai , Li Lei , He Dan , Xu Zumin , Zuo Shaoyuan , Han Jing , Wu Qiyuan , Dai Zhiyu , Cai Weibin , Ma Jianxing , Shao Chunkui , Gao Guoquan , Yang Xia 
Published: October 2017

AbstractInhibition of tumour angiogenesis has an important role in antitumour therapy. However, a recent study indicates that antiangiogenesis therapy may lead to glucose-related protein 78 (GRP78) associated antiapoptotic resistance. The present study aims to elucidate the dual effects of plasminogen kringle 5 (K5) on tumour angiogenesis and apoptosis induction by targeting hypoxia-inducible factor 1α (HIF-1α) and GRP78. Co-immunoprecipitation and western blotting were used for examining the ubiquitination of HIF-1α and analysing angiogenesis and apoptosis-associated proteins. K5 promoted the sumo/ubiquitin-mediated proteasomal degradation of HIF-1α by upregulating von Hippel-Lindau protein under hypoxia, resulting in the reduction of vascular endothelial growth factor and thus suppressing tumour angiogenesis. Furthermore, K5 decreased GRP78 expression via downregulation of phosphorylated extracellular-regulated protein kinase, leading to caspase-7 cleavage and tumour cell apoptosis. Blocking voltage-dependent anion channel abrogated the effects of K5 on both HIF-1α and GRP78. K5 significantly inhibited the growth of gastric carcinoma xenografts by inhibiting both angiogenesis and apoptosis. The dual effects suggest that K5 might be a promising bio-therapeutic agent in the treatment of gastric cancer, particularly in patients who exhibit the induction of GRP78.
Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells
Authors: Zhao Yuzu , He Jiang , Li Jun , Peng Xingzhi , Wang Xianxing , Dong Zhen , Zhao Erhu , Liu Yaling , Wu Zonghui , Cui Hongjuan 
Published: October 2017

AbstractDemethylzeylasteral is one of the extracts of Tripterygium wilfordii Hook F, which plays important roles in multiple biological processes such as inflammation inhibition, as well as immunosuppression. However, anti-cancer function and the underlying mechanisms of demethylzeylasteral in melanoma cells remain unclear. In this study, we demonstrate that demethylzeylasteral has an anti-tumor property in melanoma cells. Demethylzeylasteral not only inhibits cell proliferation through cell cycle arrest at S phase, but also induces cell apoptosis in melanoma cells. MCL1 is an anti-apoptotic protein in BCL2 family, and amplifies frequently in multiple human cancers. MCL1 is also known as a potential contributor for the resistance of BCL2 inhibitors, as well as various chemotherapeutic drugs. MCL1 is, therefore, regarded as a potential target for cancer therapy. Here, for the first time, we unveil that demethylzeylasteral suppresses the expression of MCL1. Interestingly, MCL1 interacts with S phase-related protein CDK2, and thereby inhibits it’s ubiquitin-dependent degradation. Together, demethylzeylasteral is a promising anti-tumor compound in melanoma cells. Demethylzeylasteral is also a potential inhibitor of MCL1.
Topologically protected Dirac plasmons in a graphene superlattice
Authors: Pan Deng , Yu Rui , Xu Hongxing , García de Abajo F. Javier 
Published: October 2017

AbstractTopological optical states exhibit unique immunity to defects, rendering them ideal for photonic applications. A powerful class of such states is based on time-reversal symmetry breaking of the optical response. However, existing proposals either involve sophisticated and bulky structural designs or can only operate in the microwave regime. Here we show a theoretical demonstration for highly confined topologically protected optical states to be realized at infrared frequencies in a simple two-dimensional (2D) material structure—a periodically patterned graphene monolayer—subject to a magnetic field of only 2 tesla. In our graphene honeycomb superlattice structures, plasmons exhibit substantial nonreciprocal behavior at the superlattice junctions under moderate static magnetic fields, leading to the emergence of topologically protected edge states and localized bulk modes. This approach is simple and robust for realizing topologically nontrivial optical states in 2D atomic layers, and could pave the way for building fast, nanoscale, defect-immune photonic devices.
Clay mineral formation under oxidized conditions and implications for paleoenvironments and organic preservation on Mars
Authors: Gainey Seth R. , Hausrath Elisabeth M. , Adcock Christopher T. , Tschauner Oliver , Hurowitz Joel A. , Ehlmann Bethany L. , Xiao Yuming , Bartlett Courtney L. 
Published: October 2017

AbstractClay mineral-bearing locations have been targeted for martian exploration as potentially habitable environments and as possible repositories for the preservation of organic matter. Although organic matter has been detected at Gale Crater, Mars, its concentrations are lower than expected from meteoritic and indigenous igneous and hydrothermal reduced carbon. We conducted synthesis experiments motivated by the hypothesis that some clay mineral formation may have occurred under oxidized conditions conducive to the destruction of organics. Previous work has suggested that anoxic and/or reducing conditions are needed to synthesize the Fe-rich clay mineral nontronite at low temperatures. In contrast, our experiments demonstrated the rapid formation of Fe-rich clay minerals of variable crystallinity from aqueous Fe3+ with small amounts of aqueous Mg2+. Our results suggest that Fe-rich clay minerals such as nontronite can form rapidly under oxidized conditions, which could help explain low concentrations of organics within some smectite-containing rocks or sediments on Mars.
Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions
Authors: Wong Chin Ken , Mason Alexander F. , Stenzel Martina H. , Thordarson Pall 
Published: October 2017

AbstractPolymersomes, made up of amphiphilic block copolymers, are emerging as a powerful tool in drug delivery and synthetic biology due to their high stability, chemical versatility, and surface modifiability. The full potential of polymersomes, however, has been hindered by a lack of versatile methods for shape control. Here we show that a range of non-spherical polymersome morphologies with anisotropic membranes can be obtained by exploiting hydrophobic directional aromatic interactions between perylene polymer units within the membrane structure. By controlling the extent of solvation/desolvation of the aromatic side chains through changes in solvent quality, we demonstrate facile access to polymersomes that are either ellipsoidal or tubular-shaped. Our results indicate that perylene aromatic interactions have a great potential in the design of non-spherical polymersomes and other structurally complex self-assembled polymer structures.
Sleep Benefits Memory for Semantic Category Structure While Preserving Exemplar-Specific Information
Authors: Schapiro Anna C. , McDevitt Elizabeth A. , Chen Lang , Norman Kenneth A. , Mednick Sara C. , Rogers Timothy T. 
Published: October 2017

AbstractSemantic memory encompasses knowledge about both the properties that typify concepts (e.g. robins, like all birds, have wings) as well as the properties that individuate conceptually related items (e.g. robins, in particular, have red breasts). We investigate the impact of sleep on new semantic learning using a property inference task in which both kinds of information are initially acquired equally well. Participants learned about three categories of novel objects possessing some properties that were shared among category exemplars and others that were unique to an exemplar, with exposure frequency varying across categories. In Experiment 1, memory for shared properties improved and memory for unique properties was preserved across a night of sleep, while memory for both feature types declined over a day awake. In Experiment 2, memory for shared properties improved across a nap, but only for the lower-frequency category, suggesting a prioritization of weakly learned information early in a sleep period. The increase was significantly correlated with amount of REM, but was also observed in participants who did not enter REM, suggesting involvement of both REM and NREM sleep. The results provide the first evidence that sleep improves memory for the shared structure of object categories, while simultaneously preserving object-unique information.
Observation of Quantum Zeno Blockade on Chip
Authors: Chen Jia-Yang , Sua Yong Meng , Zhao Zi-Tong , Li Mo , Huang Yu-Ping 
Published: October 2017

AbstractOverlapping in an optical medium with nonlinear susceptibilities, lightwaves can interact, changing each other’s phase, wavelength, waveform shape, or other properties. Such nonlinear optical phenomena, discovered over a half-century ago, have led to a breadth of important applications. Applied to quantum-mechanical signals, however, these phenomena face fundamental challenges that arise from the multimodal nature of the interaction between the electromagnetic fields, such as phase noises and spontaneous Raman scattering. The quantum Zeno blockade allows strong interaction between lightwaves without physical overlap between them, thus offering a viable solution for the aforementioned challenges, as indicated in recent bulk-optics experiments. Here, we report on the observation of quantum Zeno blockade on chip, where a lightwave is modulated by another in a distinct “interaction-free” manner. For quantum applications, we also verify its operations on single-photon signals. Our results promise a scalable platform for overcoming several longstanding challenges in applied nonlinear and quantum optics, enabling manipulation and interaction of quantum signals without decoherence.
Generalized phase mixing: Turbulence-like behaviour from unidirectionally propagating MHD waves
Authors: Magyar Norbert , Doorsselaere Tom Van , Goossens Marcel 
Published: October 2017

AbstractWe present the results of three-dimensional (3D) ideal magnetohydrodynamics (MHD) simulations on the dynamics of a perpendicularly inhomogeneous plasma disturbed by propagating Alfvénic waves. Simpler versions of this scenario have been extensively studied as the phenomenon of phase mixing. We show that, by generalizing the textbook version of phase mixing, interesting phenomena are obtained, such as turbulence-like behavior and complex current-sheet structure, a novelty in longitudinally homogeneous plasma excited by unidirectionally propagating waves. This study is in the setting of a coronal hole. However, it constitutes an important finding for turbulence-related phenomena in astrophysics in general, relaxing the conditions that have to be fulfilled in order to generate turbulent behavior.
HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
Authors: He Wen-Tian , Xue Wei , Gao Yong-Guang , Hong Jun-Ye , Yue Hong-Wei , Jiang Lei-Lei , Hu Hong-Yu 
Published: October 2017

AbstractHuntington’s disease (HD) is caused by aberrant expansion of polyglutamine (polyQ) in the N-terminus of huntingtin (Htt). Our previous study has demonstrated that HSP90 is involved in the triage decision of Htt, but how HSP90 recognizes and regulates Htt remains elusive. We investigated the interaction between HSP90 and the N-terminal fragments of Htt (Htt-N), such as the N-terminal 90-residue fragment (Htt-N90). Our results showed that HSP90 binds to the N-terminal extreme of Htt-N in a sequence just ahead of the polyQ tract. Structural integration of the middle and C-terminal domains of HSP90 is essential for interacting with Htt-N90, and the dimerization mediated by the C-terminal domain facilitates this interaction. Moreover, ubiquitin-specific protease 19 (USP19), a deubiquitinating enzyme interacting with HSP90, up-regulates the protein level of Htt-N90 and consequently promotes its aggregation, whereas disruption of the interaction between Htt-N90 and HSP90 attenuates the effect of USP19 on Htt-N90. Thus, HSP90 interacts with Htt-N90 on the N-terminal amphipathic α-helix, and then recruits USP19 to modulate the protein level and aggregation of Htt-N90. This study provides mechanistic insights into the recognition between HSP90 and the N-terminus of Htt, and the triage decision for the Htt protein by the HSP90 chaperone system.
Nanopore-based single molecule sequencing of the D4Z4 array responsible for facioscapulohumeral muscular dystrophy
Authors: Mitsuhashi Satomi , Nakagawa So , Takahashi Ueda Mahoko , Imanishi Tadashi , Frith Martin C. , Mitsuhashi Hiroaki 
Published: October 2017

AbstractSubtelomeric macrosatellite repeats are difficult to sequence using conventional sequencing methods owing to the high similarity among repeat units and high GC content. Sequencing these repetitive regions is challenging, even with recent improvements in sequencing technologies. Among these repeats, a haplotype carrying a particular sequence and shortening of the D4Z4 array on human chromosome 4q35 causes one of the most prevalent forms of muscular dystrophy with autosomal-dominant inheritance, facioscapulohumeral muscular dystrophy (FSHD). Here, we applied a nanopore-based ultra-long read sequencer to sequence a BAC clone containing 13 D4Z4 repeats and flanking regions. We successfully obtained the whole D4Z4 repeat sequence, including the pathogenic geneDUX4in the last D4Z4 repeat. The estimated sequence accuracy of the total repeat region was 99.8% based on a comparison with the reference sequence. Errors were typically observed between purine or between pyrimidine bases. Further, we analyzed the D4Z4 sequence from publicly available ultra-long whole human genome sequencing data obtained by nanopore sequencing. This technology may be a new tool for studying D4Z4 repeats and pathomechanism of FSHD in the future and has the potential to widen our understanding of subtelomeric regions.
Insertion sequence polymorphism and genomic rearrangements uncover hidden Wolbachia diversity in Drosophila suzukii and D. subpulchrella
Authors: Kaur Rupinder , Siozios Stefanos , Miller Wolfgang J. , Rota-Stabelli Omar 
Published: October 2017

AbstractAbility to distinguish between closely related Wolbachia strains is crucial for understanding the evolution of Wolbachia-host interactions and the diversity of Wolbachia-induced phenotypes. A useful model to tackle these issues is the Drosophila suzukii – Wolbachia association. D. suzukii, a destructive insect pest, harbor a non-CI inducing Wolbachia ‘wSuz’ closely related to the strong CI-inducing wRi strain. Multi locus sequence typing (MLST) suggests presence of genetic homogeneity across wSuz strains infecting European and American D. suzukii populations, although different Wolbachia infection frequencies and host fecundity levels have been observed in both populations. Currently, it is not clear if these differences are due to cryptic wSuz polymorphism, host background, geographical factors or a combination of all of them. Here, we have identified geographical diversity in wSuz in D. suzukii populations from different continents using a highly diagnostic set of markers based on insertion sequence (IS) site polymorphism and genomic rearrangements (GR). We further identified inter-strain diversity between Wolbachia infecting D. suzukii and its sister species D. subpulchrella (wSpc). Based on our results, we speculate that discernible wSuz variants may associate with different observed host phenotypes, a hypothesis that demands future investigation. More generally, our results demonstrate the utility of IS and GRs in discriminating closely related Wolbachia strains.
Genome-wide discovery of long intergenic noncoding RNAs and their epigenetic signatures in the rat
Authors: Li Aimin , Zhou Zhong-Yin , Hei Xinhong , Otecko Newton O. , Zhang Junying , Liu Yajun , Zhou Hongfang , Zhao Zhiqiang , Wang Lei 
Published: October 2017

AbstractLong intergenic noncoding RNAs (lincRNAs) play a crucial role in many biological processes. The rat is an important model organism in biomedical research. Recent studies have detected rat lincRNA genes from several samples. However, identification of rat lincRNAs using large-scale RNA-seq datasets remains unreported. Herein, using more than 100 billion RNA-seq reads from 59 publications together with RefSeq and UniGene annotated RNAs, we report 39,154 lincRNA transcripts encoded by 19,162 lincRNA genes in the rat. We reveal sequence and expression similarities in lincRNAs of rat, mouse and human. DNA methylation level of lincRNAs is higher than that of protein-coding genes across the transcription start sites (TSSs). And, three lincRNA genes overlap with differential methylation regions (DMRs) which associate with spontaneously hypertensive disease. In addition, there are similar binding trends for three transcription factors (HNF4A, CEBPA and FOXA1) between lincRNA genes and protein-coding genes, indicating that they harbour similar transcription regulatory mechanisms. To date, this is the most comprehensive assessment of lincRNAs in the rat genome. We provide valuable data that will advance lincRNA research using rat as a model.