bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durability in recreational runners: effects of 90-min low-intensity exercise on the running speed at the lactate threshold
Authors: Nuuttila Olli-Pekka , Laatikainen-Raussi Vesa , Vohlakari Krista , Laatikainen-Raussi Iida , Ihalainen Johanna K. 
Published: October 2024

Abstract
Purpose
Recent studies have suggested that the capability to resist deterioration of physiological characteristics could be an independent factor contributing to endurance performance. This study aimed at investigating whether prolonged low-intensity exercise induces shifts in the lactate threshold, and whether fatigue-induced changes differ between the sexes.

Methods
A total of 31 (15 females) recreational runners performed an incremental treadmill test and a 90-min low-intensity exercise (LIT90) on two separate occasions. The LIT90 was performed at 90% of the first lactate threshold speed (LT1v), derived from the incremental treadmill test. The LT1v was determined from a 5-stage (3 min) submaximal threshold test (SubmaxLT), performed before and after LIT90. The SubmaxLTs were followed by a 10/5 reactivity jump test. Respiratory gases, heart rate (HR), and HR-derived detrended fluctuation analysis alpha 1 (DFA-a1) were assessed every 15 min during the LIT90.

Results
A significant decrease (p < 0.01) was observed in the LT1v in females (− 5.8 ± 4.4%) and in males (− 5.3 ± 6.4%). The HR increased (p < 0.001) similarly in females (5.9 ± 3.1%) and in males (5.5 ± 3.6%) during the LIT90, while energy expenditure increased (3.1 ± 4.5%, p = 0.013) in females but remained unchanged in males (0.9 ± 3.1%). Change in DFA-a1 during the LIT90 was the only marker that correlated significantly with the relative change of LT1v (r = 0.463, p = 0.013).

Conclusion
LIT90 induced significant decreases in the LT1v, and the changes were comparable between sexes. DFA-a1 could be a potential intra-session marker of durability.
Host drivers of canine dirofilariosis in an arid environment of western Argentina
Authors: Cuervo Pablo Fernando , Di Cataldo Sophia , Fantozzi María Cecilia , Rodríguez María Belén , Pedrosa Analía , Mera y Sierra Roberto 
Published: October 2024

AbstractCanine dirofilariosis is a mosquito-borne zoonotic disease largely caused by Dirofilaria immitis. Mainly present in temperate, semitropical, and tropical areas, its worldwide emergence and spread are causing concern. In Argentina, most cases have been reported in humid regions of the center and northeast of the country. The occurrence of canine dirofilariosis in an arid environment of western Argentina was investigated by blood smears, microhematocrit tube test, and Knott’s technique. Association and odds ratio were determined in relation to dog characteristics. Thirty-three dogs (51.6%) had microfilariae, morphologically identified as D. immitis. Knott’s test was more sensitive in detecting the positive animals. The odds of harboring microfilariae were 12, 29, and 66 if the dog was male, adult (three to 6 years old), or older (> 7 years old), respectively. The prevalence of canine dirofilariosis herein reported outstands among the highest in Argentina and extends to the west its geographic distribution in the country. Far from being an exception, this epidemiological situation might reflect similar circumstances in several arid locations in the west and center of Argentina. Being this a disease of recent appearance in the region, both veterinarians and physicians should be aware of its potential to cause disease in animals and humans.
Lactic acid-fermented by-product of Shochu distillery reduces anxiety behavior in Neuropeptide Y knockout zebrafish by the regulation of isotoin neuron
Authors: Hibarino Momoka , Aoki Eri , Kubo Yurina , Nagata Haruri , Tateno Sayaka , Sakaguchi Kenzo , Kawaji Hirofumi , Shiozaki Kazuhiro 
Published: October 2024

AbstractThe development of techniques to reduce stress in the aquaculture industry is essential for the good growth, low mortality, and high flesh quality of farmed fish. Shochu is a traditional Japanese alcoholic beverage, and the disposal of large amounts of Shochu lees waste has been a problem. As Shochu lees contain low-molecular-weight compounds, which are thought to have health benefits, the lactic acid-fermented by-product of Shochu distillery (FBPSD) was tested to estimate its anti-stress effects in neuropeptide Y-knockout zebrafish (NPY-KO), which exhibit high anxiety and low sociability, as a farmed fish model.In the Black-White preference test, NPY-KO preferred the black area over the white area due to fear, whereas NPY-KO fed the FBPSD showed a higher preference for the white area with more swimming distance than the control group. In the 3-chambers test, NPY-KO showed low sociability with the unfamiliar zebrafish group, whereas FBPSD-fed NPY-KO showed high sociability with the group. The mRNA level of isotocin, the homologue of human oxytocin, was significantly increased in the brains of FBPSD-fed zebrafish. The oxytocin receptor antagonists L-368,899 attenuated the effects of FBPSD in the 3-chambers test. These results suggest that FBPSD attenuates anxiety in NPY-KO zebrafish by activating isotocin neurons.
Pre-existing parasympathetic dominance seems to cause persistent heart rate slowing after 6 months of fingolimod treatment in patients with multiple sclerosis
Authors: Hilz Max J. , Canavese Francesca , de Rojas-Leal Carmen , Lee De-Hyung , Linker Ralf A. , Wang Ruihao 
Published: October 2024

Abstract
Purpose
Vagomimetic fingolimod effects cause heart rate (HR) slowing upon treatment initiation but wear off with sphingosine-1-phosphate receptor downregulation. Yet, prolonged HR slowing may persist after months of fingolimod treatment. We evaluated whether cardiovascular autonomic modulation differs before and 6 months after fingolimod initiation between patients with RRMS with and without initially prolonged HR slowing upon fingolimod initiation.

Methods
In 34 patients with RRMS, we monitored RR intervals (RRI) and blood pressure (BP), at rest and upon standing up before fingolimod initiation. Six hours and 6 months after fingolimod initiation, we repeated recordings at rest. At the three time points, we calculated autonomic parameters, including RRI standard deviation (RRI-SD), RRI-total-powers, RMSSD, RRI high-frequency [HF] powers, RRI and BP low-frequency (LF) powers, and baroreflex sensitivity (BRS). Between and among patients with and without prolonged HR slowing upon fingolimod initiation, we compared all parameters assessed at the three time points (analysis of variance [ANOVA] with post hoc testing; significance: p < 0.05).

Results
Six hours after fingolimod initiation, all patients had decreased HRs but increased RRIs, RRI-SDs, RMSSDs, RRI-HF-powers, RRI-total-powers, and BRS; 11 patients had prolonged HR slowing. Before fingolimod initiation, these 11 patients did not decrease parasympathetic RMSSDs and RRI-HF-powers upon standing up. After 6 months, all parameters had reapproached pretreatment values but the 11 patients with prolonged HR slowing had lower HRs while the other 23 patients had lower parasympathetic RMSSDs and RRI-HF-powers, and BRS than before fingolimod initiation.

Conclusion
Our patients with prolonged HR slowing upon fingolimod initiation could not downregulate cardiovagal modulation upon standing up even before fingolimod initiation, and 6 months after fingolimod initiation still had more parasympathetic effect on HR while cardiovagal modulation and BRS were attenuated in the other 23 patients. Pre-existing parasympathetic predominance may cause prolonged HR slowing upon fingolimod initiation.
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition
Authors: Yang Xuejia , Zheng Fan , Yan Penghua , Liu Xueting , Chen Xuanwen , Du Xinyu , Zhang Yin , Wang Peilei , Chen Chaosheng , Lu Hong , Bai Yongheng 
Published: October 2024

Abstract
Background
Renal interstitial fibrosis (RIF) is a common feature of chronic kidney diseases (CKD), with epithelial-mesenchymal transition (EMT) being one of its important mechanisms. S100A2 is a protein associated with cell proliferation and differentiation, but its specific functions and molecular mechanisms in RIF remain to be determined.

Methods
S100A2 levels were evaluated in three mouse models, including unilateral ureteral obstruction (UUO), ischemia-reperfusion injury (IRI), and aristolochic acid nephropathy (AAN), as well as in TGF-β1- treated HK-2 cells and in kidney tissue samples. Furthermore, the role of S100A2 and its interaction with FoxO1 was investigated using RT-qPCR, immunoblotting, immunofluorescence staining, co-immunoprecipitation (Co-IP), transcriptome sequencing, and gain- or loss-of-function approaches in vitro.

Results
Elevated expression levels of S100A2 were observed in three mouse models and TGF-β1-treated HK2 cells, as well as in kidney tissue samples. Following siRNA silencing of S100A2, exposure to TGF-β1 in cultured HK-2 cells suppressed EMT process and extracellular matrix (ECM) accumulation. Conversely, Overexpression of S100A2 induced EMT and ECM deposition. Notably, we identified that S100A2-mediated EMT depends on FoxO1. Immunofluorescence staining indicated that S100A2 and FoxO1 colocalized in the nucleus and cytoplasm, and their interaction was verified in Co-IP assay. S100A2 knockdown decreased TGF-β1-induced phosphorylation of FoxO1 and increased its protein expression, whereas S100A2 overexpression hampered FoxO1 activation. Furthermore, pharmacological blockade of FoxO1 rescued the induction of TGF-β1 on EMT and ECM deposition in S100A2 siRNA-treated cells.

Conclusion
S100A2 activation exacerbates interstitial fibrosis in kidneys by facilitating FoxO1-mediated EMT.

Graphical abstract
A schematic diagram of the underlying mechanisms by which S100A2 regulates EMT and renal fibrosis. Following injury, the cytoplasmic expression of S100A2 in renal tubular epithelial cells is markedly elevated. This increase promotes the phosphorylation of FoxO1, preventing its translocation into the nucleus and enhances EMT and extracellular matrix ECM deposition, thereby exacerbating renal interstitial fibrosis.
VeLeSpa: An inflected verbal lexicon of Peninsular Spanish and a quantitative analysis of paradigmatic predictability
Authors: Herce Borja 
Published: October 2024

AbstractThis paper presents VeLeSpa, a verbal lexicon of Peninsular Spanish, which contains the full paradigms (all 63 cells) in phonological form of 6553 verbs, along with their corresponding frequencies. In this paper, the process and decisions involved in the building of the resource are presented. In addition, based on the most frequent 3000 + verbs, a quantitative analysis is conducted of morphological predictability in Spanish verbal inflection. The results and their drivers are discussed, as well as observed differences with other Romance languages and Latin.
Axisymmetric Indentation of Circular Rigid Plate on Layered Elastic Halfspace with Transverse Isotropy
Authors: Xiao Sha , Yue Zhongqi Quentin 
Published: October 2024

AbstractThis paper investigates the contact problem of a layered elastic halfspace with transverse isotropy under the axisymmetric indentation of a circular rigid plate. Fourier integral transforms and a backward transfer matrix method are used to obtain the analytical solution of the contact problem. The interaction between the rigid plate and the layered halfspace can be expressed with the standard Fredholm integral equations of the second kind. The induced elastic field in the layered halfspace can be expressed as the semi-infinite integrals of four known kernel functions. The convergence and singularity of the semi-infinite integrals near or at the surface of the layered halfspace are resolved using an isolating technique. The efficient numerical algorithms are used and developed for accurately calculating the Fredholm integral equations and the semi-infinite integrals. Numerical results show the correctness of the proposed method and the effect of layering non-homogeneity on the elastic fields in layered transversely isotropic halfspace induced by the axisymmetric indentation of a circular rigid plate.
Developmental regulation processes and age-related motivation of distance education students
Authors: Yaban E. Helin , Gaschler Robert 
Published: October 2024

AbstractThe rise of technological advancements and the pandemic have made distance education increasingly prevalent, demanding high levels of self-regulation. This research addresses the integration of three core developmental regulation models of lifespan development and the motivators proposed by self-determination theory. Although regulation models are widely used in organizational contexts, their application in education is limited. Action regulation strategies and motivation are essential for student success across the lifespan. Age diversity can also influence students’ responses to these demands. Thus, this study aimed to gain insights into regulatory processes (meta-regulation, goal engagement, and disengagement) and motivation (internal and external) in undergraduate distance-learning students of psychology. Three hundred thirty-eight students (74.9% females) from different developmental stages of emerging adulthood, early adulthood, and middle adulthood participated in an online survey (aged 18–58 years; M = 30.80, SD = 10.18). Results revealed that middle-aged students scored higher on internal motivation compared to those in emerging and early adulthood. Conversely, the emerging adult group reported higher external motivation. Canonical correlation analysis (CCA) indicated higher levels of relentlessly pursuing goals in conjunction with meta-regulation might enhance the internal motivation of distance education students across various developmental stages. This study extends developmental regulation models to (distance) education, highlighting the significant relationship between internal and external motivation. It underscores the importance of developmental regulation and motivation for students from various backgrounds. Given the growing prevalence of distance education, the study discusses implications for supporting positive outcomes for distance learners.
Ten in One: The Case of Stanza 13 in Samantabhadra’s Sixth Century Āptamīmāṃsā
Authors: Soni Jayandra 
Published: October 2024

AbstractThe title refers to an unusual instance of ten occurrences of one stanza in a single philosophical work. The stanza in question highlighted here is the outcome of a previous study on the faults (doṣas) levelled against the non-one-sided position of the Jainas, the theory of manifoldness that aims at avoiding any absolutistic standpoint or perspective concerning an object of investigation (anekāntavāda). This article draws on a study published in 2007 on doṣas or faults levelled against the Jainas. One aspect of the debate on it is dealt with here in a bit more detail: the ten occurrences of the identical stanza in Samantabhadra’s 6th century Āptamīmāṃsā (ĀM). Vidyānandin’s tenth century Aṣṭasahasrī-commentary to Āptamīmāṃsā 71 and 72 mentions a list of seven faults (doṣas) which, he says, do not apply to the Jaina anekāntavāda, with ĀM 70 thematically belonging to these two stanzas.The unique feature of ĀM 70 (which thematically belongs to ĀM 71 and 72 dealt with in the 2007 paper) in the context of Vidyānandin’s commentary is specifically dealt with here, because ĀM 70 is identical with ĀM 13, which is repeated ten times in all in Samantabhadra’s seminal work divided into ten chapters or sections (paricchedas) in the form now published. The paper will deal with some aspects of the repetitions of ĀM 70, the first occurrence being ĀM 13.
Enhancing the Sr uptake on resorcinol–formaldehyde polycondensates by modifying the structure and shape
Authors: Chavan T. A. , Devi P. S. Remya , Swain K. K. 
Published: October 2024

AbstractResorcinol–formaldehyde polycondensates—the well-established Cs-selective agents, along with their crown ether (18-crown-6) composite discs, were synthesized, characterized (FT-IR, SEM–EDS, surface area, porosity) and applied for strontium uptake from aqueous solutions. Effects of crown ether amounts, Sr in feed, pH, equilibration time, temperature, competing ions, on the sorption, along with re-usability of synthesized sorbents, were evaluated. The fate of Sr was followed by EDXRF spectrometry on both solution and solid phases. Solution pH (3–12) and temperature (upto 100 °C) had negligible impact on the holding capacities. Sorption capacity was enhanced by ~ 33% upon modification, and followed pseudo-second order kinetics.
Change detection and adaptation in multi-target regression on data streams
Authors: Stevanoski Bozhidar , Kostovska Ana , Panov Panče , Džeroski Sašo 
Published: October 2024

AbstractAn essential characteristic of data streams is the possibility of occurrence of concept drift, i.e., change in the distribution of the data in the stream over time. The capability to detect and adapt to changes in data stream mining methods is thus a necessity. While methods for multi-target prediction on data streams have recently appeared, they have largely remained without such capability. In this paper, we propose novel methods for change detection and adaptation in the context of incremental online learning of decision trees for multi-target regression. One of the approaches we propose is ensemble based, while the other uses the Page–Hinckley test. We perform an extensive evaluation of the proposed methods on real-world and artificial data streams and show their effectiveness. We also demonstrate their utility on a case study from spacecraft operations, where cosmic events can cause change and demand an appropriate and timely positioning of the space craft.
Translations and Prawitz’s Ecumenical System
Authors: Pereira Luiz Carlos , Pimentel Elaine , de Paiva Valeria 
Published: October 2024

AbstractSince Prawitz proposal of his ecumenical system, where classical and intuitionistic logics co-exist in peace, there has been a discussion about the relation between translations and the ecumenical perspective. While it is undeniable that there exists a relationship, it is also undeniable that its very nature is controversial. The aim of this paper is to show that there are interesting relations between the Gödel-Gentzen translation and the ecumenical perspective. We show that the ecumenical perspective cannot be reduced to the Gödel-Gentzen translation, much less be identified with it.
Effect of a single dose of letrozole on ejaculation time, semen quality, and testicular hemodynamics in goat bucks subjected to heat stress
Authors: Adel Ola , El-Sherbiny Hossam R. , Shahat Abdallah M. , Ismail Sayed Taha 
Published: October 2024

AbstractLetrozole (LTZ) is an aromatase inhibitor that limits estrogen (E2) production and increases testosterone (T) levels. This research aimed to examine the impact of a single dose of LTZ on testicular hemodynamics, ejaculation time, and semen quality in goats under heat stress (HS). Therefore, Doppler examination and semen evaluation were performed on twelve mature bucks for two weeks (W-1, W-2) as pre-heat stress control during winter. Then during summer HS bucks were subjected to Doppler examination, semen evaluation, and hormonal analysis (T, E2, and LH) at 0 h. Afterward, bucks were assigned into two groups and subcutaneously injected with physiological saline (n = 6; CON) or LTZ (0.25 mg/kg BW; n = 6; LTZ). Both groups were subjected to Doppler scanning and hormonal analysis at 2, 4, 24, 48, 72, 96,144, and 168 h. Semen evaluation was performed at 48 and 168 h. The LTZ group showed increasing (P < 0.05) in semen volume, sperm motility, and viability and decreasing (P < 0.05) in ejaculation time and sperm abnormalities compared to CON group at 48 h. Additionally, T concentrations increased (P < 0.01) at 2, 24, and 48 h, E2 decreased (P < 0.01) from 2 to 48 h, and LH raised (P < 0.01) at 2 and 72 h in LTZ group compared to CON one. Doppler indices reduced (P < 0.05) at 96 h in LTZ group. semen pH and scrotal circumference were not affected by LTZ. In conclusion, LTZ administration shortened ejaculation time and enhanced semen quality in bucks during HS.
Analysis of emission of volatile organic compounds and thermal degradation in investment casting using fused deposition modeling (FDM) and three-dimensional printing (3DP) made of various thermoplastic polymers
Authors: Hejna Aleksander , Marć Mariusz , Szymański Paweł , Mizera Kamila , Barczewski Mateusz 
Published: October 2024

AbstractThe study examined the degradation process of various types of polymers used to form models using the fused deposition modeling (FDM) and three-dimensional printing (3DP) methods and used in the investment casting method. Commercial filaments made of polylactide (PLA), acrylonitrile butadiene styrene terpolymer (ABS), high-impact polystyrene (HIPS), polyamide 12 (PA12), poly(methyl methacrylate) (PMMA), and polypropylene (PP) were used to produce gypsum molds. The assessment included organic volatile compounds (VOCs) released during mold heating and model degradation, which is characteristic of this technological process. The screening qualitative chromatographic analysis of decomposition products sampled from various points of the production hall made it possible to define potential threats related to the processing of selected polymers and the necessary preventive measures. Furthermore, passive diffusion-type samplers were used at the sampling stage of VOCs emitted to the gaseous phase to reduce nuisance and user interference. Studies have been completed to characterize the thermoplastic polymer degradation process. The coupled thermogravimetry (TGA) with analysis of gaseous products by infrared spectroscopy with Fourier transformation (FT-IR) has been used. The presented results are the first to compare and rate the use of this still-developing novel aspect of castings by the method of fused models.
Graphical abstract