bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic-control multifunctional acoustic metasurface for reflected wave manipulation at deep subwavelength scale
Authors: Chen Xing , Liu Peng , Hou Zewei , Pei Yongmao 
Published: August 2017

AbstractAcoustic metasurfaces, exhibiting superior performance with subwavelength thickness, are ideal alternatives for functionalities such as wavefront modulation and acoustic energy trapping, etc. However, most of the reported acoustic metasurfaces were passive. Here a magnetically tuned mechanism is reported for membrane-type acoustic metamaterials. Harnessing the geometric nonlinearity of membrane structures, the transmission spectrum is both theoretically and experimentally tuned over broadband by an external static magnetic force. Simultaneously, the phase profiles can be readily tailored by the magnetic stimulus. Further, a magnetic-control multifunctional metasurface is proposed for low-frequency wave manipulation. By switching the magnetic force distribution, multi extraordinary phenomena, such as acoustic wave redirecting, focusing, bending, etc., are realized without changing the physical structure. Besides, it is demonstrated the proposed metasurface, at deep subwavelength scale (~1/85λ), supports anomalous reflected wave manipulation over a wide band. These results open up new degrees of freedom to steer acoustic wave and pave a way for designing active acoustic devices.
Projecting potential distribution of Eucryptorrhynchus scrobiculatus Motschulsky and E. brandti (Harold) under historical climate and RCP 8.5 scenario
Authors: Ji Yingchao , Luo Wen , Zhang Ganyu , Wen Junbao 
Published: August 2017

AbstractAilanthus altissima (Mill.) Swingle and its variant A. altissima var. Qiantouchun are notorious invasive weeds. Two weevils, Eucryptorrhynchus scrobiculatus (ESC) and E. brandti (EBR) are considered as candidates for biological control of A. altissima. The aim of this study was to model the potential distributions of ESC and EBR using CLIMEX 4.0. The projected potential distributions of ESC and EBR included almost all current distribution areas of A. altissima, except Southeast Asia. Under historical climate, potential distribution area of EBR is larger than that of ESC, 46.67 × 106 km2 and 35.65 × 106 km2, respectively. For both ESC and EBR, climate change expanded the northern boundary of potential distributions northward approximately 600 km by the middle of 21st century, and 1000 km by the end of 21st century under RCP 8.5. However, the suitable range decreased to the south in the Southern Hemisphere because of heat stress. The modelled potential distributions of ESC and EBR in the United States demonstrated that the climate was suitable for both weevils. Therefore, considering only climate suitability, both ESC and EBR can be considered as potential biological control agents against A. altissima with some confidence that climatic conditions are likely suitable.
Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens
Authors: Huang Shu-cheng , Rehman Mujeeb Ur , Lan Yan-fang , Qiu Gang , Zhang Hui , Iqbal Muhammad Kashif , Luo Hou-qiang , Mehmood Khalid , Zhang Li-hong , Li Jia-kui 
Published: August 2017

AbstractTibial dyschondroplasia (TD) is an intractable poultry problem that is characterized by the appearance of non-vascularized and non-mineralized cartilage masses in tibial growth plates (TGPs). However, the role of angiogenesis inhibition in the occurrence of TD remains unknown. In this study, we found that, compared to low-altitude Arbor Acres chickens (AACs), high-altitude Tibetan chickens showed higher tibial vascular distributions that were accompanied by up-regulation of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor A (VEGFA) and VEGF receptors. These observations provide insights into hypoxia-induced angiogenesis, which may be related to the absence of TD in high-altitude native Tibetan chickens. Importantly, hypoxia experiments also showed that during hypoxia, tibial angiogenesis was enhanced, which was due to pro-angiogenic factor up-regulation (including VEGFA, VEGFR1, VEGFR2, and IL-8), in AACs. Moreover, we observed that thiram-induced TD could strongly inhibit tibial angiogenesis in the hypertrophic zone through coordinated down-regulation of HIF-1α and pro-angiogenic factors, leading to a disruption in the blood supply to the TGP. Taken together, these findings reveal that the occurrence of TD is highly associated with inhibition of tibial angiogenesis through down-regulated expression of HIF-1α, VEGFA and VEGF receptors, which results in suppression of TGP development.
Genome-wide comparative analysis of H3K4me3 profiles between diploid and allotetraploid cotton to refine genome annotation
Authors: You Qi , Yi Xin , Zhang Kang , Wang Chunchao , Ma Xuelian , Zhang Xueyan , Xu Wenying , Li Fuguang , Su Zhen 
Published: August 2017

AbstractPolyploidy is a common evolutionary occurrence in plants. Recently, published genomes of allotetraploid G. hirsutum and its donors G. arboreum and G. raimondii make cotton an accessible polyploid model. This study used chromatin immunoprecipitation with high-throughput sequencing (ChIP-Seq) to investigate the genome-wide distribution of H3K4me3 in G. arboreum and G. hirsutum, and explore the conservation and variation of genome structures between diploid and allotetraploid cotton. Our results showed that H3K4me3 modifications were associated with active transcription in both cottons. The H3K4me3 histone markers appeared mainly in genic regions and were enriched around the transcription start sites (TSSs) of genes. We integrated the ChIP-seq data of H3K4me3 with RNA-seq and ESTs data to refine the genic structure annotation. There were 6,773 and 12,773 new transcripts discovered in G. arboreum and G. hirsutum, respectively. Furthermore, co-expression networks were linked with histone modification and modularized in an attempt to explain differential H3K4me3 enrichment correlated with changes in gene transcription during cotton development and evolution. Taken together, we have combined epigenomic and transcriptomic datasets to systematically discover functional genes and compare them between G. arboreum and G. hirsutum, which may be beneficial for studying diploid and allotetraploid plants with large genomes and complicated evolution.
Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite
Authors: Demarta-Gatsi Claudia , Peronet Roger , Smith Leanna , Thiberge Sabine , Ménard Robert , Mécheri Salaheddine 
Published: August 2017

AbstractWhile most subunit malaria vaccines provide only limited efficacy, pre-erythrocytic and erythrocytic genetically attenuated parasites (GAP) have been shown to confer complete sterilizing immunity. We recently generated aPlasmodium berghei(PbNK65) parasite that lacks a secreted factor, the histamine releasing factor (HRF) (PbNK65hrfΔ), and induces in infected mice a self-resolving blood stage infection accompanied by a long lasting immunity. Here, we explore the immunological mechanisms underlying the anti-parasite protective properties of the mutantPbNK65hrfΔ and demonstrate that in addition to an up-regulation of IL-6 production, CD4+but not CD8+T effector lymphocytes are indispensable for the clearance of malaria infection. Maintenance of T cell-associated protection is associated with the reduction in CD4+PD-1+and CD8+PD-1+T cell numbers. A higher number of central and effector memory B cells in mutant-infected mice also plays a pivotal role in protection. Importantly, we also demonstrate that prior infection with WT parasites followed by a drug cure does not prevent the induction ofPbNK65hrfΔ-induced protection, suggesting that such protection in humans may be efficient even in individuals that have been infected and who repeatedly received antimalarial drugs.
Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
Authors: Xu Cheng , Shu Yaqin , Fu Zhi , Hu Yuanli , Mo Xuming 
Published: August 2017

AbstractLittle is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient = 0.022, 95% CI 0.003, 0.041; P = 0.022) and LDL-cholesterol in adolescents (age 12–19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend = 0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.
Silicon rich nitride ring resonators for rare – earth doped telecommunications-band amplifiers pumped at the O-band
Authors: Xing P. , Chen G. F. R. , Zhao X. , Ng D. K. T. , Tan M. C. , Tan D. T. H. 
Published: August 2017

AbstractRing resonators on silicon rich nitride for potential use as rare-earth doped amplifiers pumped at 1310 nm with amplification at telecommunications-band are designed and characterized. The ring resonators are fabricated on 300 nm and 400 nm silicon rich nitride films and characterized at both 1310 nm and 1550 nm. We demonstrate ring resonators exhibiting similar quality factors exceeding 10,000 simultaneously at 1310 nm and 1550 nm. A Dysprosium-Erbium material system exhibiting photoluminescence at 1510 nm when pumped at 1310 nm is experimentally demonstrated. When used together with Dy-Er co-doped particles, these resonators with similar quality factors at 1310 nm and 1550 nm may be used for O-band pumped amplifiers for the telecommunications-band.
Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project
Authors: Chen Yang , Li Jie , Hu Yanling , Zhang Haiying , Yang Xiaobo , Jiang Yonghua , Yao Ziting , Chen Yinchun , Gao Yong , Tan Aihua , Liao Ming , Lu Zhen , Wu Chunlei , Xian Xiaoyin , Wei Suchun , Zhang Zhifu , Chen Wei , Wei Gong-Hong , Wang Qiuyan , Mo Zengnan 
Published: August 2017

AbstractChronic prostatitis (CP) is a complex disease. Fragmentary evidence suggests that factors such as infection and autoimmunity might be associated with CP. To further elucidate potential risk factors, the current study utilized the Fangchenggang Area Male Health and Examination Survey (FAMHES) project; where 22 inflammatory/immune markers, hormone markers, tumor-related proteins, and nutrition-related variables were investigated. We also performed baseline, regression, discriminant, and receiver operating characteristic (ROC) analyses. According to NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), participants were divided into chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, pain ≥ 4; divided into IIIa and IIIb sub-groups) and non-CPPS (pain = 0; divided into IV and normal sub-groups). Analyses revealed osteocalcin as a consistent protective factor for CP/CPPS, NIH-IIIb, and NIH-IV prostatitis. Further discriminant analysis revealed that ferritin (p = 0.002) and prostate-specific antigen (PSA) (p = 0.010) were significantly associated with NIH-IIIa and NIH-IV prostatitis, respectively. Moreover, ROC analysis suggested that ferritin was the most valuable independent predictor of NIH-IIIa prostatitis (AUC = 0.639, 95% CI = 0.534–0.745,p = 0.006). Together, our study revealed inflammatory/immune markers [immunoglobulin E, Complement (C3, C4), C-reactive protein, anti-streptolysin, and rheumatoid factors], hormone markers (osteocalcin, testosterone, follicle-stimulating hormone, and insulin), tumor-related proteins (carcinoembryonic and PSA), and a nutrition-related variable (ferritin) were significantly associated with CP or one of its subtypes.
Longitudinal observations of progressive cardiac dysfunction in a cardiomyopathic animal model by self-gated cine imaging based on 11.7-T magnetic resonance imaging
Authors: Saito Shigeyoshi , Tanoue Minori , Masuda Kasumi , Mori Yuki , Nakatani Satoshi , Yoshioka Yoshichika , Murase Kenya 
Published: August 2017

AbstractThe purpose of this study was to longitudinally assess left ventricular function and wall thickness in a hamster model of cardiomyopathy using 11.7-T magnetic resonance imaging (MRI). MRI were performed for six cardiomyopathic J2N-k hamsters and six J2N-n hamsters at 5, 10, 15, and 20 weeks of age. Echocardiography was also performed at 20 weeks. The ejection fraction (EF) at 15 and 20 weeks of age in J2N-k hamsters showed a significant decrease compared with those in controls. Conversely, the end-systolic and end-diastolic volumes in cardiomyopathic hamsters showed a significant increase compared with those in controls. Moreover, the heart walls of J2N-k hamsters at 15 and 20 weeks were thicker than those of controls at end-systole; however, there were no significant differences at end-diastole. Optical microscopy with Masson’s trichrome staining depicted no fibrosis in the control myocardium, although it showed interstitial fibrosis in the 20-week-old J2N-k cardiomyopathic myocardium. There were no differences in EF and the wall thickness observed on MRI and those observed on echocardiography. These results indicate the presence of systolic dysfunction in cardiomyopathic hamsters. Self-gated cine imaging based on 11.7-T MRI can be used for serial measurements of cardiac function and wall thickness in a cardiomyopathic model.
GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor
Authors: Fusco Joseph , Xiao Xiangwei , Prasadan Krishna , Sheng Qingfeng , Chen Congde , Ming Yung-Ching , Gittes George 
Published: August 2017

AbstractExendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin-4 can stimulate β-cell proliferation. The exact mechanism of action to induce β-cell proliferation is not well understood. Here, using a β-cell specific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase in proliferation and β-cell mass through EGFR. Thus, our study sheds light on the role of EGFR signaling in the effects of exendin-4 on the control of blood glucose metabolism and β-cell mass.
Polylysine‐modified titania nanotube arrays for local drug delivery
Authors: Zhang Tao , Liu Yan , Zhang Fengfen , Xiao Xiufeng 
Published: August 2017

A drug delivery system based on ɛ‐polylysine‐modified titania nanotube (ɛ‐PL‐TNTs) arrays was prepared. Polylysine on the nanotubes’ surface can effectively bind with alendronate, a drug for the treatment of osteoporosis, through chemical bond. The bonds are fairly stable in an acid environment and cannot easily break up in a physiological environment. The ɛ‐PL‐TNTs increased the amount of drug loading by 9% in weight. The in vitro release profile of alendronate from ɛ‐PL‐TNTs showed a significant reduced burst release and an extended overall release of more than 15 days.
Thermoelectric transport calculation of Si nanoclusters with different geometric shapes
Authors: Lu Peng‐Xian , Lu Man‐Man , Kong Chun , Zhang Meng , Zhao Zhi‐Wei 
Published: August 2017

Fabricating small‐sized Si nanoclusters has been considered as an effective approach to obtain a high figure‐of‐merit of thermoelectric materials. To reveal the electron and phonon transport in the Si nanoclusters with different geometric shapes, the electronic structure, the lattice dynamics and the thermoelectric properties of Si nanobox, Si nanocylinder, Si nanosphere and Si nanotetrahedron were investigated through first‐principles calculation, lattice simulation and Boltzmann transport theory. The influences of the electronic structure and the lattice dynamics on the thermoelectric properties were also studied in detail. Therefore the work provides a complete understanding on the thermoelectric transport in the Si nanoclusters with different geometric shapes. Moreover, a largely enhanced figure‐of‐merit (ZT) at 1200 K of 1.70 has been achieved for Si nanobox.
Taming Silylium Ions for Synthesis: N-Heterocycle Synthesis via Stereoselective C–C Bond Formation
Authors: Gagné Michel , Moyer Brandon 
Published: August 2017

Silylium ions (formally [R3Si]+) have long been the subject of investigations and significant debate in both theoretical and experimental chemistry, but few catalytic, synthetic applications have been reported due to the exceptionally high reactivity and Lewis acidity of these elusive species. Results to be discussed include the application of easily accessible silylium ion catalysts to the stereoselective synthesis of various N-heterocyclic pyrrolidine and piperidine scaffolds. The tested substrates are derived from the chiral pool and can be obtained in three high-yielding steps from amino alcohols; subsequent stereoselective silylium ion catalyzed Prins cyclization and trapping with R3Si–Nu nucleophiles (e.g., Nu = H, allyl, azide, and enol ethers) results in novel nitrogen-containing polycyclic scaffolds with potential medicinal chemistry applications.
“Beauty in the lap of horror”: the Gothic appeal of Erich von Stroheim in Blind Husbands (1919) and Foolish Wives (1922)
Authors: Girelli Elisabetta 
Published: August 2017

AbstractThis article revisits a seminal figure of film history, the director/actor/scriptwriter Erich von Stroheim, focusing on his early work, and arguing that a Gothic framework is the most appropriate context for making sense of his complex, subversive persona; equally, the essay shows how two films dealing with urban, sophisticated characters, set in modern locations such as Monte Carlo, are in fact drenched in Gothic sensibility and aesthetics. As the director and star of Blind Husbands (1919) and Foolish Wives (1922), the Austrian-born Erich von Stroheim has so far been analysed as a catalyst for post-WWI stereotypes of unwelcome foreignness in the USA. Irrupting in a context fraught with anxieties about “evil Huns”, immigration, and ambivalent notions of Europeanness, Stroheim’s films caused both outrage and admiration. While film scholars have read Stroheim’s perceived transgression through his symbolic role of Germanic alien, they have paid scant attention to the films themselves. This omission has effectively ignored other powerful evocations emerging from Stroheim’s work, and the way its suggestions of contemporary identities are subsumed into a much wider, richer narrative: a Gothic narrative. Equally, scholars have correctly mobilized, yet not fully addressed, the essential contradiction at the basis of Stroheim’s roles: their inexplicable quality of repulsion-attraction, or in other words, Gothic abjection. This article acknowledges the films’ linkability to post-WWI xenophobia, yet argues that their subversive aspects lie in a Gothic system of signification, allowing for yet vastly exceeding cultural and national references of the period; the Gothic also provides a framework where the unresolved tensions of Stroheim’s work can meaningfully coexist. Blind Husbands and Foolish Wives centre on a staple Gothic figure, the aberrant male seducer, a “satanic” protagonist who is both molester and object of erotic desire, irresistible yet repulsive. Visually and narratively reliant on Gothic tropes, from “sublimely horrible” mise-en-scene to intimations of rape and sadism, the films daringly validate not the merely objectionable, but the abject, embodied in Erich von Stroheim’s perverse masculinity.
Recruitment of CRISPR-Cas systems by Tn7-like transposons
Authors: Peters Joseph E. , Makarova Kira S. , Shmakov Sergey , Koonin Eugene V. 
Published: August 2017

SignificanceCRISPR-Cas is an adaptive immunity system that protects bacteria and archaea from mobile genetic elements. We present comparative genomic and phylogenetic analysis of minimal CRISPR-Cas variants associated with distinct families of transposable elements and develop the hypothesis that such repurposed defense systems contribute to the transposable element propagation by facilitating transposition into specific sites. Thus, these transposable elements are predicted to propagate via RNA-guided transposition, a mechanism that has not been previously described for DNA transposons.
What kind of literature is a literary translation?
Authors: Robinson Douglas 
Published: August 2017

AbstractThis paper is a kind of manifesto for a new conception of literary translation as a unique literary genre that is imitative but qualitatively different from, and not necessarily worse than, the model it imitates. It explores this possibility by first interrogating Gérard Genette’s model of literariness inFiction and Diction – considering how literary translation as a unique genre might fit that model – and then considering what the literary translator imitates, and the relationship between translation and the novel as similar imitative genres. Key to this comparison is the novel’s early (and continuing) reliance on the “found-translation framing device,” which is effectively what Gideon Toury calls a pseudotranslation but is not (necessarily) designed tohideoriginal creation – rather, to play with the illusion of reality. The paper ends with the suggestion that literature tout court might be reimagined in terms of its transformative energies – and that translation might come to be seen as one of literature’s most definitive genres.
Oral administration of ovalbumin after sensitization attenuates symptoms in a mouse model of food allergic enteropathy
Authors: Hiraide Erika , Morinaga Mamiko , Hidaka Hiroki , Yamada Satoki , Takeyama Jun , Kitamura Noriko , Kaminuma Osamu , Hiroi Takachika , Du Weibin , Ohashi-Doi Katsuyo , Nakajima-Adachi Haruyo , Hachimura Satoshi 
Published: August 2017

Abstract
Oral immunotherapy (OIT) is a promising treatment of food allergy. To administer an appropriate oral dose of an allergenic component as OIT to individuals sensitized with a food allergen may prevent inducing food allergic inflammation in them. So we attempted to establish a mouse model to evaluate efficacy for oral administration of food allergen after sensitization. In BALB/c mice sensitized by injecting ovalbumin (OVA) with alum twice, OVA was administered before inducing inflammation by feeding the mice with egg white (EW) diet. Severe inflammatory responses, such as enteropathy, weight loss, IL-4 production, and increase of IgE antibody levels, were suppressed by administration with 4 mg of OVA 7 times before feeding EW diet. OVA administration alone induced a slight Th2 response, but no symptoms. The current study demonstrated that severe food allergic enteropathy could be prevented by pre-administration with appropriate dose of OVA to sensitized mice.