bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel 5‐(Benzo[b]thiophen‐3‐yl)pyridine‐3‐carbaldehyde (BTPA) Functionalization Framework For Modulating Fullerene Electronics
Authors: John Suru V. , De Filippo Christian C. , Silvestrini Simone , Maggini Michele , Iwuoha Emmanuel 
Published: April 2017

AbstractThrough a cycloaddition reaction, fullerene (C60) was derivatized with a novel organic compound 5‐(benzo[b]thiophen‐3‐yl)pyridine‐3‐carbaldehyde to form the processable and stable 3‐(benzo[b]thiophene‐3yl)‐5‐fullero‐1‐methylpyrrolidinepyridine (BTFP) compound. BTFP exhibits close similarities to phenyl‐C61‐butyric‐acid‐methyl‐ester (PCBM) in terms of first reduction potential values (−0.62 and −0.61 V vs. Ag/AgCl, for BTFP and PCBM, respectively) and lowest occupied molecular orbital (LUMO) energy level values (3.93 eV in both cases). In chloroform, BTFP exhibits a bathochromic shift in the λmax of BTFP (λmax,BTFP=290 nm and λmax,PCBM=260 nm), owing to the grafted benzo[b]thiophene‐3‐yl)pyridine moiety. Despite the similarity in LUMO (3.93 eV) energy values, BTFP and PCBM differ in their luminescence‐quenching ability. The bathochromic shift in the λmax of BTFP (relative to PCMB) is likely to contribute to improved light absorption of a suitable donor for photovoltaic applications.
In Situ Testing of Flexible Electronics
Authors: Gastaldi Dario 
Published: April 2017

AbstractIf you are looking for Peter Gips, Torben Becker, Ulrich Oechsner and Gregor Federau: Analyzing Filiform Corrosion, Optik Photonik 12(2), p. 40, April 2017, please click here: 10.1002/opph.201700008.Quantitative information is central to the research and development efforts of flexible electronic devices. This article discusses the research of Dario Gastaldi and his group at the Politecnico di Milano, on how the flexible conductive connection between electrical components, known as ‘the interconnect’, has benefited from in situ mechanical testing coupled to the quantitative imaging capabilities of the LEXT OLS4100 and its specialized objectives, which has a design optimized for the 405 nm laser wavelength. The Gastaldi group has generated quantitative evidence to support how interconnect geometry determines device integrity under strain. Such information facilitates numerical modelling systems for optimising the design process. The evolution of crack formation is also followed in more detail, while it has also been shown that plasma treatment of polymer can be detrimental to device strength under strain.
Fusion gene addiction: can tumours be forced to give up the habit?
Authors: Selfe Joanna L , Shipley Janet 
Published: April 2017

AbstractFusion of genes in tumours can have oncogenic roles in reprogramming cells through overexpression of oncogenes or the production of novel fusion proteins. A fundamental question in cancer biology is what genetic events are critical for initiation and whether these are also required for cancer progression. In recent work published in The Journal of Pathology, dependency on a fusion protein was addressed using a model of alveolar rhabdomyosarcomas – a sarcoma subtype with frequent fusion of PAX3 and FOXO1 genes that is associated with poor outcome. PAX3–FOXO1 encodes a potent transcription factor that together with MYCN alters the transcriptional landscape of cells. Building on previous work, an inducible model in human myoblast cells was used to show that PAX3–FOXO1 and MYCN can initiate rhabdomyosarcoma development but, contrary to current thinking, tumour recurrences occasionally arose independent of the fusion protein. Further work needs to identify the molecular nature of this independence and assess any relevance in human tumours. Such functional approaches are required together with computational modeling of molecular data to unravel spatial and temporal dependencies on specific genetic events. This may support molecular prognostic markers and therapeutic targets. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Tubulin β‐III modulates seizure activity in epilepsy
Authors: Xu Xin , Shangguan Yafei , Lu Shanshan , Wang Wei , Du Chao , Xiao Fei , Hu Yida , Luo Jing , Wang Liang , He Changlong , Yang Yong , Zhang Yanke , Lu Xi , Yang Qin , Wang Xuefeng 
Published: April 2017

AbstractTubulin β‐III (TUBB3) is the most dynamic β‐tubulin isoform expressed in neurons, and is highly expressed in the central nervous system. However, the relationship between TUBB3 and epileptic seizures has not been thoroughly investigated. The aims of this study were to investigate the expression of TUBB3 in patients with temporal lobe epilepsy and two different rat models of chronic epilepsy, and to determine the specific roles of TUBB3 in epilepsy. TUBB3 expression was upregulated in human and rat epileptic tissue. Moreover, TUBB3 expression was associated with inhibitory GABAergic neurons and the inhibitory postsynaptic scaffold protein gephyrin. TUBB3 downregulation attenuated the behavioural phenotypes of epileptic seizures during the pilocarpine‐induced chronic phase of epileptic seizures and the pentylenetetrazole kindling process, whereas TUBB3 overexpression had the opposite effect. Whole‐cell clamp recordings and western blotting revealed that the amplitude of GABA‐A receptor‐mediated miniature inhibitory postsynaptic currents and the surface expression of the GABA‐A receptor were increased in rats in which TUBB3 expression was downregulated. Importantly, TUBB3 interacted with GABA‐A receptor‐associated protein, which is known to be involved in GABA‐A receptor trafficking. These results indicate that TUBB3 plays a critical role in the regulation of epileptic seizures via GABA‐A receptor trafficking, suggesting a molecular mechanism for new therapeutic strategies. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Vegetation Succession, Carbon Accumulation and Hydrological Change in Subarctic Peatlands, Abisko, Northern Sweden
Authors: Gałka Mariusz , Szal Marta , Watson Elizabeth J. , Gallego‐Sala Angela , Amesbury Matthew J. , Charman Dan J. , Roland Thomas P. , Edward Turner T. , Swindles Graeme T. 
Published: April 2017

AbstractHigh‐resolution analyses of plant macrofossils, testate amoebae, pollen, mineral content, bulk density, and carbon and nitrogen were undertaken to examine the late Holocene dynamics of two permafrost peatlands in Abisko, Subarctic Sweden. The peat records were dated using tephrochronology, 14C and 210Pb. Local plant succession and hydrological changes in peatlands were synchronous with climatic shifts, although autogenous plant succession towards ombrotrophic status during peatland development was also apparent. The Marooned peatland experienced a shift ca. 2250 cal yr BP from rich to poor fen, as indicated by the appearance of Sphagnum fuscum. At Stordalen, a major shift to wetter conditions occurred between 500 and 250 cal yr BP, probably associated with climate change during the Little Ice Age. During the last few decades, the testate amoeba data suggest a deepening of the water table and an increase in shrub pollen, coinciding with recent climate warming and the associated expansion of shrub communities across the Arctic. Rates of carbon accumulation vary greatly between the sites, illustrating the importance of local vegetation communities, hydrology and permafrost dynamics. Multiproxy data elucidate the palaeoecology of S. lindbergii and show that it indicates wet conditions in peatlands. Copyright © 2017 John Wiley & Sons, Ltd.
Medication errors involving anticoagulants: Data from the Danish patient safety database
Authors: Henriksen Jakob Nørgaard , Nielsen Lars Peter , Hellebek Annemarie , Poulsen Birgitte Klindt 
Published: April 2017

AbstractReporting of adverse incidents is mandatory in Denmark. All reported adverse incidents are made anonymously, and stored in an encrypted database. It is the purpose of this descriptive study to describe the severity of adverse medication incidents caused by oral anticoagulants in hospitals. All moderate, severe and fatal reports concerning non‐vitamin K antagonist oral anticoagulants were analyzed from date of marketing until July 8 2014. The data collection for warfarin was from January 1 2014 until July 8 2014. Three independent specialists in clinical pharmacology evaluated the severity of incident outcomes. A total of 147 adverse medication incidents were analyzed, and showed that de facto or potentially fatal and serious incidents were most frequently associated with sector change (admission to or discharge from hospital, or undergoing surgery) and resulted from insufficient or excess dosing. Physicians should be aware when prescribing and changing anticoagulant therapy to avoid severe or fatal incidents.
Assessment of model chemistries for hydrofluoropolyethers: A DFT/M08‐HX benchmark study
Authors: Viegas Luís P. 
Published: April 2017

AbstractIn this work, we report the first detailed theoretical comparative conformational investigation between two different classes of hydrofluoropolyethers: dihydro‐ and dimethoxyfluoropolyethers. The main objective was to determine a cost‐effective computational methodology that could accurately reproduce the energetic rankings and thermal weight factors of the simplest examples of those two classes calculated with M08‐HX/triple‐ζ//M08‐HX/double‐ζ benchmark model chemistries. Between the tested methodologies, M08‐HX/aug‐pcseg‐2//M08‐HX/pcseg‐1 was found to be the most appropriate, exhibiting a good accuracy and considerable reduction in computational cost with respect to the benchmark, being more than three times faster than M08‐HX/aug‐pcseg‐2//M08‐HX/aug‐pcseg‐1. This cost‐effective approach will be essential in future work when studying larger hydrofluoropolyethers, where the computational complexity associated with increasing number of conformers will require such approximations.
Compound‐specific hydrogen isotope analysis of fluorine‐, chlorine‐, bromine‐ and iodine‐bearing organics using gas chromatography–chromium‐based high‐temperature conversion (Cr/HTC) isotope ratio mass spectrometry
Authors: Renpenning Julian , Schimmelmann Arndt , Gehre Matthias 
Published: April 2017

RationaleThe conventional high‐temperature conversion (HTC) approach towards hydrogen compound‐specific isotope analysis (CSIA) of halogen‐bearing (F, Cl, Br, I) organics suffers from incomplete H2 yields and associated hydrogen isotope fractionation due to generation of HF, HCl, HBr, and HI byproducts. Moreover, the traditional off‐line combustion of highly halogenated compounds results in incomplete recovery of water as an intermediary compound for hydrogen isotope ratio mass spectrometry (IRMS), and hence also leads to isotope fractionation. This study presents an optimized chromium‐based high‐temperature conversion (Cr/HTC) approach for hydrogen CSIA of various fluorinated, chlorinated, brominated and iodinated organic compounds. The Cr/HTC approach is fast, economical, and not affected by low H2 yields and associated isotope fractionation.MethodsThe performance of the modified gas chromatography/chromium‐based high‐temperature conversion (GC‐Cr/HTC) system was monitored and optimized using an ion trap mass spectrometer. Quantitative conversion of organic hydrogen into H2 analyte gas was achieved for all halogen‐bearing compounds. The corresponding accuracy of CSIA was validated using (i) manual dual‐inlet (DI)‐IRMS after off‐line conversion into H2, and (ii) elemental analyzer (EA)‐Cr/HTC‐IRMS (on‐line conversion).ResultsThe overall hydrogen isotope analysis of F‐, Cl‐, Br‐ and I‐bearing organics via GC‐Cr/HTC‐IRMS achieved a precision σ ≤ 3 mUr and an accuracy within ±5 mUr along the VSMOW‐SLAP scale compared with the measured isotope compositions resulting from both validation methods, off‐line and on‐line. The same analytical performance as for single‐compound GC‐Cr/HTC‐IRMS was achieved compound‐specifically for mixtures of halogenated organics following GC separation to baseline resolution.ConclusionsGC‐Cr/HTC technology can be implemented in existing analytical equipment using commercially available materials to provide a versatile tool for hydrogen CSIA of halogenated and non‐halogenated organics. Copyright © 2017 John Wiley & Sons, Ltd.
Possible ability of bovine follicular fluid to attract migrating bull spermatozoa
Authors: Mondal MD Anisuzzaman , Takagi Yuji , Baba Shoji A. , Hamano Koh‐ichi 
Published: April 2017

AbstractAimTo examine the potential of bovine follicular fluid (BFF) to attract bull spermatozoa.MethodsThe ability of the BFF to attract bull sperm was evaluated by observing changes in sperm migration after being placed in a cross‐column chamber. The movement parameters of the heads and flagella of the sperm that were attracted to the BFF were analyzed by using the Computer Assisted Sperm Analysis system.ResultsIt was observed that 61.6% of the bull sperm migrated toward the BFF when the BFF was used at a concentration of 0.1%, but 67.2% of the sperm did not migrate toward the BFF at a concentration of 10%. Relatively larger numbers of both precapacitated and postcapacitated bull sperm migrated toward the BFF (0.1%). The ability of the 0.1% BFF to attract sperm probably affected both the normal artificial insemination (AI) fertility sperm and the poor AI fertility spermatozoa. The flagellar curvilinear ratio of the sperm winding to the 0.1% BFF was significantly higher than that of the prewinding sperm.ConclusionThese results could suggest that BFF potentially attracts bull sperm at a certain concentration, irrespective of the capacitation status of the sperm. Although the mechanism by which this attraction occurs remains unclear, these data imply that it could be related to BFF‐dependent changes in the sperm flagellar curvilinear ratio.
Core Vocabulary: Its Morphological Content and Presence in Exemplar Texts
Authors: Hiebert Elfrieda H. , Goodwin Amanda P. , Cervetti Gina N. 
Published: April 2017

AbstractThis study addresses the distribution of words in texts at different points of schooling. The first aim was to identify a core vocabulary that accounts for the majority of the words in texts through the lens of morphological families. Results showed that 2,451 morphological families, averaging 4.61 members, make up the core vocabulary of school texts. The 11,298 words in the 2,451 morphological families account for 58% of the approximately 19,500 most frequent words in written English. The majority of the morphological families appear by the end of the elementary school period (85%), but a small group of morphological families (15%) is added through the middle to high school period. Analyses of the ranks of words across grade bands indicated that late‐appearing words gain in prominence in higher level texts as some elementary‐level words become less frequent. The second aim of the study was to determine the degree to which the core vocabulary accounted for the words in an independent but critical set of texts: the exemplar texts identified within the Common Core State Standards. The 2,451 families accounted for 97.1% (grades K and 1) to 89.1% (grade 11 through college) of the total words in texts and 95.6% (grades K and 1) to 74.9% (grade 11 through college) of the unique words in texts. Implications of the findings on the nature and role of the core vocabulary in complex texts are suggested for researchers, curriculum developers, and publishers.
Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial
Authors: Dawson Geraldine , Sun Jessica M. , Davlantis Katherine S. , Murias Michael , Franz Lauren , Troy Jesse , Simmons Ryan , Sabatos-DeVito Maura , Durham Rebecca , Kurtzberg Joanne 
Published: April 2017

Abstract
Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed. We hypothesized that umbilical cord blood-derived cell therapies may have potential in alleviating ASD symptoms by modulating inflammatory processes in the brain. Accordingly, we conducted a phase I, open-label trial to assess the safety and feasibility of a single intravenous infusion of autologous umbilical cord blood, as well as sensitivity to change in several ASD assessment tools, to determine suitable endpoints for future trials. Twenty-five children, median age 4.6 years (range 2.26–5.97), with a confirmed diagnosis of ASD and a qualified banked autologous umbilical cord blood unit, were enrolled. Children were evaluated with a battery of behavioral and functional tests immediately prior to cord blood infusion (baseline) and 6 and 12 months later. Assessment of adverse events across the 12-month period indicated that the treatment was safe and well tolerated. Significant improvements in children's behavior were observed on parent-report measures of social communication skills and autism symptoms, clinician ratings of overall autism symptom severity and degree of improvement, standardized measures of expressive vocabulary, and objective eye-tracking measures of children's attention to social stimuli, indicating that these measures may be useful endpoints in future studies. Behavioral improvements were observed during the first 6 months after infusion and were greater in children with higher baseline nonverbal intelligence quotients. These data will serve as the basis for future studies to determine the efficacy of umbilical cord blood infusions in children with ASD.
Innovating Corporate Accounting and Reporting for Sustainability – Attributes and Challenges
Authors: Schaltegger Stefan , Etxeberria Igor Álvarez , Ortas Eduardo 
Published: April 2017

AbstractThe environmental and social impacts of companies and their processes, products and supply chains are a widespread concern. At the same time, such impacts provide opportunities for firms to engage in sustainability practices, to transform their businesses or to start new ventures contributing to sustainable development. In this context, innovation can be an important supportive vehicle for developing corporate sustainability management and accounting practices to effectively contribute to sustainable development. Based on the six attributes proposed by Baregheh et al. () to characterise innovations, this paper discusses what innovation in accounting for sustainability may encompass. Although significant efforts have been made, a reorientation and more research are needed to develop corporate accounting approaches to address environmental and social challenges more effectively. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Basic psychological need experiences, fatigue, and sleep in individuals with unexplained chronic fatigue
Authors: Campbell Rachel , Tobback Els , Delesie Liesbeth , Vogelaers Dirk , Mariman An , Vansteenkiste Maarten 
Published: April 2017

AbstractGrounded in self‐determination theory, this study tested the hypothesis that the satisfaction and frustration of the psychological needs for autonomy, competence, and relatedness would relate to fatigue and subjective and objective sleep parameters, with stress and negative sleep cognitions playing an explanatory role in these associations. During a stay at a sleep laboratory in Belgium, individuals with unexplained chronic fatigue (N = 160; 78% female) underwent polysomnography and completed a questionnaire at 3 different points in time (i.e., after arrival in the sleep lab, before bedtime, and the following morning) that assessed their need‐based experiences and stress during the previous week, fatigue during the preceding day, and sleep‐related cognitions and sleep during the previous night. Results indicated that need frustration related to higher stress, which in turn, related to higher evening fatigue. Need frustration also related to poorer subjective sleep quality and shorter sleep duration, as indicated by both subjective and objective shorter total sleep time and subjective (but not objective) longer sleep latency. These associations were accounted for by stress and negative sleep cognitions. These findings suggest that health care professionals working with individuals with unexplained chronic fatigue may consider focusing on basic psychological needs within their therapeutic approach.
Exogenous coordination of concurrent software components with JavaBIP
Authors: Bliudze Simon , Mavridou Anastasia , Szymanek Radoslaw , Zolotukhina Alina 
Published: April 2017

SummaryA strong separation of concerns is necessary in order to make the design of domain‐specific functional components independent from cross‐cutting concerns, such as concurrent access to the shared resources of the execution platform. Native coordination mechanisms, such as locks and monitors, allow developers to address these issues. However, such solutions are not modular; they are complex to design, debug, and maintain. We present the JavaBIP framework that allows developers to think on a higher level of abstraction and clearly separate the functional and coordination aspects of the system behavior. It implements the principles of the Behavior, Interaction, and Priority (BIP) component framework rooted in rigorous operational semantics. It allows the coordination of existing concurrent software components in an exogenous manner, relying exclusively on annotations, component APIs, and external specification files. We introduce the annotation and specification syntax of JavaBIP and illustrate its use on realistic examples, present the architecture of our implementation, which is modular and easily extensible, and provide and discuss performance evaluation results. Copyright © 2017 John Wiley & Sons, Ltd.
1,8‐Naphthalimide: A Potent DNA Intercalator and Target for Cancer Therapy
Authors: Tandon Runjhun , Luxami Vijay , Kaur Harsovin , Tandon Nitin , Paul Kamaldeep 
Published: April 2017

AbstractThe poor pharmacokinetics, side effects and particularly the rapid emergence of drug resistance compromise the efficiency of clinically used anticancer drugs. Therefore, the discovery of novel and effective drugs is still an extremely primary mission. Naphthalimide family is one of the highly active anticancer drug based upon effective intercalator with DNA. In this article, we review the discovery and development of 1,8‐naphthalimide moiety, and, especially, pay much attention to the structural modifications and structure activity relationships. The review demonstrates how modulation of the moiety affecting naphthalimide compound for DNA binding that is achieved to afford a profile of antitumor activity. The DNA binding of imide and ring substitution at naphthalimide, bisnaphthalimide, naphthalimide‐metal complexes is achieved by molecular recognition through intercalation mode. Thus, this synthetic/natural small molecule can act as a drug when activation or inhibition of DNA function, is required to cure or control the cancer disease. The present study is a review of the advances in 1,8‐naphthalimide‐related research, with a focus on how such derivatives are intercalated into DNA for their anticancer activities.