bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome
Authors: Liang Qiaoxing , Lin Guo‐Wang , Ding Xiaohu , Zou Bin , Liu Xiaomin , Li Jing , Zhang Yuxin , Wen Xiaofeng , Liang Lingyi , Bei Jin‐Xin , He Mingguang , Jia Huijue , Wei Lai 
Published: October 2024

AbstractGene expression is a molecular phenotype shaped by the interplay between genotype and environment. The microbiome represents a critical environmental exposure for the host. However, the genotype‐microbiome interactions (GMIs) shaping the host transcriptome remain largely unexplored. Here, we integrated conjunctival multiomics data from 120 pairs of twins to investigate GMIs. We identified 272,972 expression quantitative trait loci associated with 5946 genes and 241,073 genotype‐controlled correlations between gene expression and microbial abundance. We developed a modeling approach, MicroGenix, that screens for GMIs from host genome, transcriptome, and microbiome data and identifies GMIs associated with the disease through gene‐based association tests. We applied MicroGenix to the conjunctival data set and found that incorporating GMIs into gene expression prediction models significantly increased prediction accuracy. The genes with increased accuracy were overrepresented by those encoding cell adhesion molecules. We further used MicroGenix to predict the transcriptome from conjunctival metagenomes and identified GMIs associated with ocular surface disease. Our work provides a resource for studying host‐microbiome interactions at the conjunctiva and a computational approach to investigate GMIs using multiomics data.
Evaluation of TikTok social media posts on side effect information for popular weight loss medications
Authors: Singleton Jerica , Wantuch Gwendolyn A. 
Published: October 2024

AbstractIntroductionThe prevalence of overweight and obesity is increasing in America, contributing to various health risks. Glucagon‐like peptide‐1 (GLP‐1) and gastric inhibitory peptide (GIP) receptor agonists have bloomed in popularity due to their efficacy and United States Food and Drug Administration (FDA) approval for weight loss, igniting popularity on social media. This study focuses on the role of TikTok™ (ByteDance, Haidian, Beijing, China), a popular social media platform, in disseminating understandable and actionable information about the side effects of weight loss medications.MethodsThe study analyzed the top 50 TikTok videos for each of the following hashtags: #ozempicsideeffects, #semaglutidesideeffects, #mounjarosideeffects, and #wegovysideeffects. Videos were evaluated based on their understandability and actionability using the Patient Education Materials Assessment Tool (PEMAT) for audio‐visual (AV) products. PEMAT‐AV scores and popularity of videos were compared between hashtags utilizing one‐way analysis of variance (ANOVA). An alpha of 0.05 was used, with Bonferroni correction.ResultsA total of 165 videos were reviewed for PEMAT‐AV understandability and actionability scores. The total visibility of the videos reached over 19.4 million views. A majority of the videos were personal experiences (89%), with only 5% being health care education videos. The average understandability and actionability scores for all videos were 43% and 20%, respectfully. The data presented a difference between searched hashtags for both evaluation scores, p‐values of <0.001 and 0.093, respectively.ConclusionTikTok videos covering weight loss medication side effects have poor understandability and actionability scores. This study highlights the opportunity for more educational videos produced by health care professionals on TikTok, and a potential need for health care organizations and/or colleges of pharmacy to provide education to health care providers on how to create quality content for medication education on social media‐based platforms. Further research is needed to evaluate the credibility of content.
A perspective on alignment between steady‐state design and control for a distillation system in the context of flexibility analysis
Authors: Kong Zong Yang , Ang Tiffany , Adi Vincentius Surya Kurnia , Sunarso Jaka 
Published: October 2024

AbstractThis perspective paper discusses the alignment between steady‐state design and control (dynamic) simulation in the context of flexibility analysis for distillation systems. Operational variations, such as fluctuations in feed composition or flowrate, can stem from external factors like raw material quality or temperature variations. These disturbances need to be mitigated to ensure optimal industrial performance. Traditionally, these process uncertainties are usually considered in a sequential manner, where the steady‐state flowsheet is established first, and control performance is analyzed afterwards. However, recent studies have started integrating flexibility index into the design phase to account for process uncertainties. While this integration has improved design strategies, aligning steady‐state and dynamic control simulations for comprehensive flexibility analysis remains underexplored. In this paper, we wish to share new perspectives and insights we have observed by analyzing the existing literature. We highlight some points not immediately apparent in our previous studies, hoping these insights will serve as guidelines for future research in this direction. We believe that validating results between steady‐state and control simulations is a long‐term endeavor that cannot be conclusively addressed soon. However, we hope this paper will be valuable to future researchers, contributing to advancing this field and reaching those who will appreciate and build upon these insights. © 2024 Society of Chemical Industry (SCI).
Seasonality in Sonoran pronghorn survival and movement within a managed rangeland
Authors: Barbour Nicole , Bright Jill , Hervert John , Gurarie Eliezer D. , Fuest Stephanie , Alvidrez Aaron , Goodwin R. Andrew , Su Steven , Lehmuth Sherry , Black Christian W. , Fleming Christen H. , Fagan William F. 
Published: October 2024

AbstractThe endangered Sonoran pronghorn (Antilocapra americana sonoriensis) has a large portion of its range within a military operations area in southwestern Arizona, USA. Sonoran pronghorn have been actively managed in this region for more than 20 years. Recovery efforts have included release of captive‐born pronghorn into areas both currently and historically occupied by wild pronghorn. These areas provide habitat for federally endangered essential and experimental non‐essential, referred to as 10(j), pronghorn populations. More than 20 years of monitoring efforts have resulted in a large dataset on their spatial occurrence and movement within these areas. To synthesize long‐term trends and seasonality in Sonoran pronghorn movement and mortality, we employed a suite of quantitative analyses that characterized the pronghorns' 1) individual and population‐level home ranges, 2) occurrence near active military targets, 3) trends in seasonal group sizes and composition, 4) sex‐ and group‐specific survivorship, and 5) changes in movement‐based behavior following release from captivity. We found strong seasonal trends throughout, including sex‐specific differences in seasonal movement rates, home ranges, survival, and group composition. Further, captive‐born pronghorn released into the endangered population exhibited markedly higher survival compared to those released in 10(j) areas. Captive‐born pronghorn exhibited significant seasonal use of active military target areas. These analyses, which represent the most comprehensive analysis of Sonoran pronghorn movement and survival to date, have important implications for the future conservation and management of this endangered species. Our results indicate that active management of endangered Sonoran pronghorn has successfully increased survival, and we recommend maintaining or increasing current recovery efforts, such as captive breeding and placement of supplemental resources throughout their range (e.g., freestanding water and supplemental forage), to further boost the survivorship of both wild‐ and captive‐born pronghorn. Moreover, future management efforts could use our seasonality results to create dynamic prediction models of when and where pronghorn are likely to overlap with military activities to best manage interactions. Our methods have added application to other mobile species of conservation interest occurring in disturbed and resource‐limited landscapes.
Effects of Different Land Uses and Slope on Runoff and Soil Loss on the Loess Plateau of China
Authors: Cui Zhiwei , Li Peng , Zhang Lei , Wang Tian , Ma Jianye , Xiao Lie , Zhao Binhua , Han Jianchun , Yan Zixuan , Gómez José A. 
Published: October 2024

ABSTRACTThe Loess Plateau has one of the most serious areas of soil erosion in China; therefore, studying the effect of soil and water conservation measures on the erosion of loess soil slopes is important for land management and agricultural development. This study is based on 5 years of field runoff observations and rainfall data from 2015 to 2019. Correlation and regression analyses were used to study the runoff and sediment production of loess soil and its relationship with rainfall, slope and land use. The results show that > 80% of the erosive rainfall occurs mainly in July to August in the area. Runoff and soil loss from the plots differed substantially, depending on land use, soil conservation measures and slope degree. Bare plots experienced the highest soil loss rate of over 27 t/ha with higher runoff depth, followed by cultivated plots (4.55 t/ha), grass plots (0.43 t/ha), shrub plots (0.35 t/ha) and forest plots (0.13 t/ha). Among the four soil and water conservation measures, the runoff and sediment reduction benefits of forest and shrub plots were the highest. The runoff reduction benefit fluctuated at approximately 0.8, and the benefit of sediment reduction was ≈1. The overall performance was forest > shrubland > grassland > cultivated land > bare land, and the benefits of sediment reduction were greater than those of runoff reduction. Forests had the highest soil retention capacity on slopes from 5° to 25°, and forests on gentle slopes had the best water storage capacity. Shrub plots had the best water storage capacity when they were on steep slopes. Rainfall erosion forces were significantly and positively correlated (p < 0.01) with runoff depth and soil loss, making it the most significant rainfall indicator of sediment production. Under the same rainfall conditions, soil and water conservation measures are still required on bare slopes, land use is the main control factor for slope sediment production, and appropriate land use can greatly reduce the threat of slopes in terms of soil erosion. This study shows that soil and water conservation measures are imperative to prevent runoff and soil loss, especially for bare land without any measures; on steep slopes, a vegetation combination primarily featuring shrubs is expected to achieve greater benefits in reducing runoff and sediment. This study can provide a scientific basis for the management of vegetation measures and the implementation of soil and water conservation measures on loess soil slopes.
Mineralized Biopolymers‐Based Scaffold Encapsulating with Dual Drugs for Alveolar Ridge Preservation
Authors: Tran Thanh‐Han Hoang , Luu Cuong Hung , Nguyen Khanh‐Tram Thi , Hoang Mai‐Anh Le , Pham Quang‐Khanh , Phan Chau My , Thai Nguyen‐Kim‐Luong , Nguyen Hieu Trung , Thambi Thavasyappan , Phan V.H. Giang 
Published: October 2024

AbstractMineralization of scaffolds is essential for alveolar ridge preservation and bone tissue engineering, enhancing the mechanical strength and bioactivity of scaffolds, and promoting better integration with natural bone tissue. While the in situ mineralization method using concentrated SBF solutions is promising, there is limited comprehensive research on its effects. In this study, it is demonstrate that soaking gelatin/alginate scaffolds (GAS) in fivefold concentrated SBF significantly reduces the mineralization time to 3–7 days but also leads to considerable degradation and loss of the scaffold's original microstructure. The ratio of gelatin to alginate is optimized to improve the properties of GAS. The optimized GAS sample, when soaked in concentrated SBF to form GAS/HAp, exhibited hydroxyapatite (HAp) crystal formation starting from day 3, with mature hexagonal crystals forming by day 7. However, this process also caused significant decomposition and deformation of the scaffold's pore structure. Additionally, the biocompatibility of GAS and GAS/HAp is evaluated through in vitro, in ovo, haemolysis, and anti‐ROS assays. The findings highlight the impact of SBF5× on the mineralization of GAS, laying the groundwork for further research in alveolar ridge preservation and bone tissue engineering.
Rainbows and laughter: How humor boosts e‐Word‐of‐Mouth for LGBT+ brands on social media
Authors: O'Rourke Anne‐Maree , Belli Alex , Mathmann Frank , Septianto Felix 
Published: October 2024

AbstractLGBT+ brands, i.e., those supporting and catering for the LGBT+ community and primarily owned and operated by members of this community, have been standing out for their authenticity in a marketplace where brands are regularly accused of “rainbow‐washing.” Yet, despite the recent media spotlight these brands are still struggling to grow and gain visibility among the general public. This study aims to explore how LGBT+ brands can leverage their content to increase e‐Word‐of‐Mouth (eWOM) on social media. Specifically, we focus on humorous content because its impact on eWOM has been mixed in the literature and brand type has been overlooked as a potential moderator to date. Using brand anthropomorphism and schema congruity theory, our research proposes that LGBT+ brands that adopt humor in their social media content generate higher eWOM when compared to mainstream brands. We suggest that consumers attribute the expected characteristics of gay individuals (e.g., humorous, witty, …) to LGBT+ brands, thus leading to perceived brand‐post fit as the underlying mechanism. Two studies based on Facebook data from two different LGBT+ brands and a scenario‐based experiment validate these findings. Alongside conceptualizing LGBT+ brands, we provide valuable insights into how these brands can gain exposure and visibility on social media.
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model
Authors: Martinez Elisa , Berg Noémie , Rodriguez Cristina , Daube Georges , Taminiau Bernard 
Published: October 2024

AbstractClostridioides difficile is an anaerobic, spore‐forming, Gram‐positive pathogenic bacterium. This study aimed to analyze the effect of two samples of healthy fecal microbiota on C. difficile gene expression and growth using an in vitro coculture model. The inner compartment was cocultured with spores of the C. difficile polymerase chain reaction (PCR)‐ribotype 078, while the outer compartment contained fecal samples from donors to mimic the microbiota (FD1 and FD2). A fecal‐free plate served as a control (CT). RNA‐Seq and quantitative PCR confirmation were performed on the inner compartment sample. Similarities in gene expression were observed in the presence of the microbiota. After 12 h, the expression of genes associated with germination, sporulation, toxin production, and growth was downregulated in the presence of the microbiota. At 24 h, in an iron‐deficient environment, C. difficile activated several genes to counteract iron deficiency. The expression of genes associated with germination and sporulation was upregulated at 24 h compared with 12 h in the presence of microbiota from donor 1 (FD1). This study confirmed previous findings that C. difficile can use ethanolamine as a primary nutrient source. To further investigate this interaction, future studies will use a simplified coculture model with an artificial bacterial consortium instead of fecal samples.
Resilience in Cyclicality: Impact of Inventory Management Efficiency on Operational Profitability
Authors: Yeboah Samuel , Kjærland Frode , Kustec Irena 
Published: October 2024

ABSTRACTThe cyclical and non‐cyclical nature of the consumer goods industry presents unique dynamics that require discernment in analyzing working capital (WC). These firms often deal with considerable inventory levels that create costs and liquidity challenges, particularly during economic downturns. This paper investigates the impact of inventory days (InvD) on operating margin (OM) in both demand‐stable and demand‐sensitive businesses. The empirical analysis employs system GMM regression with a sample of publicly traded US consumer goods firms from 2010 to 2022. The findings reveal an inverted U‐shaped relationship between InvD and OM among cyclical companies, indicating that these firms require a comparatively lower optimal inventory level (108 days) to maximize profitability at 3%. The results highlight the importance of strategic inventory management (IM) under varying economic and demand conditions and balancing the risks of stock‐outs against the costs of overstocking to optimize profitability. This paper contributes to the literature on the impact of inventory dynamics on operating profit in stable and volatile markets. It estimates the optimal inventory level that enhances profitability and predicts the optimal inventory dynamics for maximum profit.
Ruminant Trans Fatty Acid Intake Modulates Inflammation Pathways in the Adipose Tissue Transcriptome of C57BL/6 Mice
Authors: Mohammadi Farzad , Beauparlant Charles Joly , Bianco Stéphanie , Droit Arnaud , Bertrand Nicolas , Rudkowska Iwona 
Published: October 2024

ScopeThe study aims to analyze transcriptomic profiles in adipose tissues postconsumption of elaidic acid (EA; trans‐18:1n‐9) and trans‐palmitoleic acid (TPA; trans‐16:1n‐7), elucidating their different effects on inflammation and glucose metabolism.Methods and resultsTwenty C57BL/6 mice are divided into four groups. Each group receives one of the following formulations in drinking water: lecithin nanovesicles, nanovesicles containing either lecithin with EA or TPA (86:14 w/w), or water (control) for 28 days with a regular fat diet (18% calories from fat). Total RNA is extracted, and paired‐end sequencing is performed. TPA intake alters the expression of 351 genes compared to EA intake, including 11 downregulated and 340 upregulated genes (fold change [FC] >1.5, p < 0.05). TPA compares to EA upregulated: Slc5a8, Lcn2, Csf3, Scube1, Mapk13, Bdkrb2, Ctla2a, Slc2a1, Oas3, Cx3cl1, Oas2, Nlrp6, Pycard, Cyba, Ddr1, and Prkab1 and downregulated Fas gene. These genes are related to the NOD‐like receptor, lipid and atherosclerosis, IL‐17 signaling, TNF, nonalcoholic fatty liver disease, cytokine–cytokine receptor interaction, adipocytokine, glucagon, insulin resistance, and inflammatory mediator regulation of TRP channels signaling.ConclusionTPA intake has a distinct impact on the regulation of inflammation and diabetes‐related pathways in adipose tissue compared to EA.
Phase contrast MRI with minimized background phase errors
Authors: Loecher Michael , Ennis Daniel B. 
Published: October 2024

AbstractPurposePhase contrast MRI (PC‐MRI) is used clinically to measure velocities in the body, but systematic background phase errors caused by magnetic field imperfections corrupt the velocity measurements with offsets that limit clinical utility. This work aims to minimize systematic background phase errors in PC‐MRI, thereby maximizing the accuracy of velocity measurements.MethodsThe MRI scanner's background phase errors from eddy currents and mechanical oscillations were modeled using the gradient impulse response function (GIRF). Gradient waveforms were then numerically optimized using the GIRF to create pulse sequences that minimize the background phase errors. The pulse sequences were tested in a static phantom where the predicted response could be compared directly to the measured background velocity. The optimized acquisitions were then tested in human subjects, where flow rates and background errors were compared to conventional PC‐MRI.ResultsWhen using the GIRF‐optimized gradient waveforms, the predicted background phase was within 0.6 [95% CI = −3.4, 5.4] mm/s of the measured background phase in a static phantom. Excellent agreement was seen for in vivo blood flow values (flow rate agreement = 0.96), and the background phase was reduced by 78.8 18.7%.ConclusionThis work shows that using a GIRF to model the effects of magnetic field imperfections combined with numerically optimized gradient waveforms enables PC‐MRI waveforms to be designed to produce a minimal background phase in the most time‐efficient manner. The methodology could be adapted for other MRI sequences where similar magnetic field errors affect measurements.
Fourier Transform Approach to Boundary Domain Integral Equations for Elastic Composites With Domain Decomposition and Multi Reference Parameters
Authors: To Quy‐Dong , Bonnet Guy 
Published: October 2024

ABSTRACTIn this article, displacement and strain periodic boundary domain integral equations for homogenization problems of elastic composites are derived in the context of FFT homogenization methods. The resolution methods based on regular grids and discrete Green's tensors are presented. The displacement based equations can be used to solve problems in arbitrary domains under periodic and non‐periodic boundary conditions. The strain based integral equation is obtained from the combination of the displacement based equations for different domains, each one having its own reference elasticity tensor. In the latter, the strain values inside every phases are connected to material mismatch parameters on the phase boundary. It was shown that by decomposing suitably domains by stiffness and using adapted reference parameters, the iteration schemes converge faster.
Biological aging analysis based on DNA methylation status for social anxiety disorder
Authors: Noguchi Nobuhiko , Shirai Toshiyuki , Suda Akira , Hattori Saki , Miyauchi Masatoshi , Okazaki Satoshi , Fujita Junichi , Asami Takeshi , Otsuka Ikuo , Hishimoto Akitoyo 
Published: October 2024

AbstractAimSocial anxiety disorder (SAD) is a common disorder characterized by excessive fear of scrutiny and embarrassment, leading to severe distress and avoidance behaviors or dysfunctions. SAD and other relevant diseases have been reported to be associated with a higher risk of aging‐related diseases, such as Alzheimer's disease, Parkinson's disease, and diabetes mellitus. Recently, epigenetic clock analysis, which measures biological aging based on comprehensive DNA methylation (DNAm) status, has been widely conducted. We conducted epigenetic clock analyses in patients with SAD and controls, examining various epigenetic age acceleration and DNAm‐based predictive values of aging‐related proteins (GrimAge components and GrimAge2 components), including leptin level.MethodsWe used the publicly available DNAm dataset, GSE164056, which consists of 66 patients with SAD and 77 controls of Caucasian descent aged between 18 and 50 years. We conducted regression analyses investigating the association between SAD and various indices of epigenetic aging, using age and sex as covariates.ResultsNone of the epigenetic clocks showed significant differences in age acceleration. Of the DNAm‐based predictive values of aging‐related proteins, leptin level in GrimAge components (q = 0.0123) and GrimAge2 components (q = 0.0123) were significantly lower in patients with SAD than in controls.ConclusionsThe results of this study suggested that leptin may be involved in SAD pathogenesis as an aging‐related protein. Therefore, further studies with different designs are required.