bluuebunny/crossref_metadata_2025_split huggingface dataset:
Langzeitergebnisse und Patientenzufriedenheit nach Tympanoplastik mit
Titan-Clip-Prothesen
Authors: Wolferts Guido , Schicke Daniel , Delank K.-Wolfgang 
Published: May 2017

ZusammenfassungZiel der vorliegenden Arbeit ist die Evaluation der Langzeitergebnisse nach
Ossikelkettenrekonstruktion mittels Titan-Clip Prothesen. Hierzu wurde eine
retrospektive Analyse mit prospektivem Follow-up bei allen Patienten
durchgeführt, bei denen in den Jahren 2002–2013 ein Clip-PORP implantiert wurde.
Es erfolgten audiologische Messungen, otoskopische Untersuchungen sowie die
Evaluation der Lebensqualität mittels Glasgow Benefit Inventory. 48 Patienten
(51 Ohren, 29 Männer, 19 Frauen, Durchschnittsalter 44,1 Jahre) konnten für das
Follow-up rekrutiert werden, der Nachbeobachtungszeitraum lag im Mittel bei 6,3
Jahren. Die Schallleitungskomponente wurde insgesamt (0,5–4 kHz) von präoperativ
22,8 dB auf 14,6 dB postoperativ reduziert (p≤0,001). Häufigste
Operationsindikation waren Cholesteatome und -Rezidive (52%), gefolgt von
chronischen Otitiden (12%), Radikalhöhlenrevisionen (8%) und
Schallleitungsstörungen nach Voroperation (14%). In 47 Fällen war das
Trommelfell verschlossen (92,2%), 4x (7,8%) bestand ein Defekt. Die Prothese war
39 Mal (75%) in situ, 6x (11,8%) lag eine Protrusion bzw. 2x (4%) eine
Verkippung vor, 1x (2%) war die Prothese fehlend und 3x (5,9%) konnte es nicht
beurteilt werden. Die postinterventionelle Patientenzufriedenheit wurde
insgesamt positiv bewertet (8,4 Punkte), ebenso die allgemeine Unterskala
während bei den Unterskalen soziale Unterstützung und körperliche Gesundheit
keine Veränderung auftraten. Zusammenfassend ist die Ossikuloplastik mittels
Titan-Clip Prothesen ein sicheres und etabliertes Verfahren. Auch langfristig
werden gute und stabile audiologische Messresultate durch Reduktion der
Schallleitungskomponente aufgezeigt. Die subjektive Lebensqualität ist insgesamt
nachhaltig verbessert.
Ellagic Acid Administration Negated the Development of Streptozotocin-Induced Memory Deficit in Rats
Authors: Bansal Nitin , Yadav Pushplata , Kumar Manish 
Published: May 2017

AbstractRampant production of pro-oxidants and inadequate antioxidant availability in brain exert oxidative stress, which in synergism with impaired glucose metabolism and inflammation leads to neurodegeneration and cognitive deficits. Ellagic acid (EGA) is a phenolic compound present in various fruits and is reported to possess robust antioxidant and anti-inflammatory properties. The present study investigated the effect of EGA administration on streptozotocin (STZ) induced dementia in rats. Bilateral intracerebroventricle (ICV) injection of STZ (3 mg/kg) was given to Wistar rats (200 g) on day 1 and 3. EGA (17.5 and 35 mg/kg) was administered orally to rats for 28 days daily. The spatial memory of rats was quantified by using Morris water maze and elevated plus maze. Brain TBARS, GSH and TNF-α were also measured. Administration of EGA prevented the induction of STZ-ICV triggered cognitive deficits as evident by a significant (p<0.05) reduction in mean escape latency during acquisition trial and increased (p<0.05) time spent in target quadrant during retrieval trial in Morris water maze test, and reduction (p<0.05) in transfer latency in elevated plus maze test. Furthermore, both the doses of EGA attenuated STZ-ICV induced rise in brain TBARS as well as TNF-α and simultaneously enhanced the GSH content. Thus, EGA ameliorated STZ-induced dementia by probably restoring the balance between cellular pro-oxidants and anti-oxidants in brain of rats.
Laboratory measurements of HDO/H2O isotopic fractionation during ice deposition in simulated cirrus clouds
Authors: Lamb Kara D. , Clouser Benjamin W. , Bolot Maximilien , Sarkozy Laszlo , Ebert Volker , Saathoff Harald , Möhler Ottmar , Moyer Elisabeth J. 
Published: May 2017

SignificanceThe preferential deposition of heavy water (HDO orH218O) as ice is a fundamental tracer in the geosciences, used for understanding paleoclimate and water cycling, but the basic physical chemistry is not well measured. We describe here measurements of the preferential fractionation of HDO vs. H2O at the cold temperatures relevant to cirrus clouds on Earth and snow on Mars. We also provide a quantitative demonstration of kinetic isotope effects in nonequilibrium conditions, and show how targeted dynamic experiments can be used to understand processes at ice surfaces.
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
Authors: Boyle Evan A. , Andreasson Johan O. L. , Chircus Lauren M. , Sternberg Samuel H. , Wu Michelle J. , Guegler Chantal K. , Doudna Jennifer A. , Greenleaf William J. 
Published: May 2017

Significance
Cas9, a protein derived from the bacterial CRISPR/Cas9 immune system, relies on a programmable single-guide RNA (sgRNA) to bind specific genomic sequences. Cas9 complexed with sgRNA readily binds on-target DNA, but models that can predict the specificity of this process have proven elusive. To investigate this system from a biophysical perspective, we applied a massively parallel method for profiling protein–DNA interactions to quantify nuclease-dead Cas9 (dCas9) binding across thousands of off-target sequences. We observe that mismatches at certain positions of the guide lead to complex dCas9 dissociation patterns, and multiple mismatches between the gRNA and DNA at nonseed bases can produce substantial changes in observed association and dissociation, suggesting the possibility of kinetic and thermodynamic tuning of Cas9 behavior.
Pride
Authors: Athanasiadou Angeliki 
Published: May 2017

Abstract
The aim of the paper1 is to discuss the linguistic and conceptual devices employed for the expression of the emotion of pride in English and Greek culture. The focus will be (a) on the way the emotion of pride is conceptualized in the two cultures, (b) on the way it is expressed, not only in terms of lexical entities but also in terms of expressions in which the two cognitive processes, metaphor and metonymy, feature, and moreover, how the interplay between them is realized, and (c) on the role of the emotion of pride in the English and Greek cultural framework.
Language rights in the constitutions, organic acts, and statutes of the territories of the United States and the Freely Associated States
Authors: Faingold Eduardo D. 
Published: May 2017

AbstractThe constitutions, organic acts, and statutes of the territories of the United States and the Freely Associated States are given an exhaustive screening to identify legal language defining the linguistic obligations of each territory or associated state and the language rights of individuals and groups dwelling within. The author suggests that the territories of the United States and the Freely Associated States are well served by “hands-on” policies declaring provisions that protect the rights of language minority groups, or of all people living in the territory (i.e., Guam, the Northern Mariana Islands, Puerto Rico, and American Samoa) and associated states (i.e., the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau). As in many states in the United States, the absence of an explicit language policy in the United States Virgin Islands has not prevented it from practicing implicit language policies that promote the use of English while also allowing minority languages to be used in the territory. Unlike many states in the United States which declare English as the sole official language and/or enact provisions to protect official English, none of the territories and associated states of the United States declares English as the sole official language or establishes provisions that hinder the rights of language minority groups.
Teop – an Oceanic language with multifunctional verbs, nouns and adjectives
Authors: Mosel Ulrike 
Published: May 2017

Abstract
The corpus-based analysis of Teop word classes demonstrates that lexical multifunctionality is not incompatible with the grammatical distinction between verbs, nouns, adjectives and adverbs, because this distinction does not manifest itself in their syntactic functions of heads of phrases, but in the kinds of modifier the words can combine with. Consequently, the Teop word class system falsifies all word class typologies that assume that a formal differentiation of event, object and property words presupposes a distinctive distribution across the head positions of determiner-marked referential expressions and TAM-marked predicative expressions. In addition to the multifunctionality of verbs, nouns and adjectives, the Teop lexicon shows regular patterns of conversion. The paper concludes with an assessment of the results and the limitations of the corpus-based approach and suggests four topics for further research: (1) the development of elicitation methods to supplement corpus-based analyses; (2) a typology of formally distinguished phrase types; (3) regular patterns of conversion across languages; and (4) possessive comparative constructions.
Roots and stems in Amis and Nêlêmwa (Austronesian)
Authors: Bril Isabelle 
Published: May 2017

AbstractIn constrast with Nêlêmwa (Oceanic, New Caledonia) whose lexemes are most generally subcategorised as nouns or verbs and undergo category-changing derivations, in Amis (Formosan), roots are pervasively categorially neutral, yet they contain semantic features and instructions that allow or disallow combination with primary derivational affixes which specify their class and category. Lexical categories are expressed after roots are derived into morphosyntactic words projected in a syntactic frame; they are then quite rigidly subcategorised as verbal, nominal or adjectival-modifying heads. Still, word forms display some functional flexibility; for instance, nouns and derived nouns, pronouns, numerals may be predicative in equative, ascriptive and focus constructions, simply by being in the syntactic position of the verb. Such functional flexibility is asymmetrical and does not apply to derived verb stems which must be nominalised to achieve argument function.
Describing spatial layouts as an L2M2 signed language learner
Authors: Ferrara Lindsay , Nilsson Anna-Lena 
Published: May 2017

Abstract
This study explores the L2M2 acquisition of Norwegian Sign Language by hearing adults, with a focus on the production and use of
depicting signs. A group of students and their instructors were asked to respond to prompt questions about directions and
locations in Norwegian Sign Language, and their responses were then compared. An examination of the students’ depicting signs
shows that they struggled more with the phonological parameters orientation and movement, rather than with handshape. In addition,
they used fewer depicting signs than their instructors, and instead relied more on lexical signs. Finally, students were found to
struggle with the coordination of depicting signs within the signing space and in relation to their own bodies. It is hoped that
the findings from this study can be used to inform future research as well as curricula development and pedagogy.
Emerging linguistic features of Sao Tome and Principe Sign Language
Authors: Mineiro Ana , Carmo Patrícia , Caroça Cristina , Moita Mara , Carvalho Sara , Paço João , Zaky Ahmed 
Published: May 2017

AbstractIn Sao Tome and Principe there are approximately five thousand deaf and hard-of-hearing individuals. Until recently, these people had no language to use among them other than basic home signs used only to communicate with their families. With this communication gap in mind, a project was set up to help them come together in a common space in order to create a dedicated environment for a common sign language to emerge.In less than two years, the first cohort began to sign and to develop a newly emerging sign language – the Sao Tome and Principe Sign Language (LGSTP). Signs were elicited by means of drawings and pictures and recorded from the beginning of the project. The emergent structures of signs in this new language were compared with those reported for other emergent sign languages such as the Al-Sayyid Bedouin Sign Language and the Lengua de Señas de Nicaragua, and several similarities were found at the first stage.In this preliminary study on the emergence of LGSTP, it was observed that, in its first stage, signs are mostly iconic and exhibit a greater involvement of the articulators and a larger signing space when compared with subsequent stages of LGSTP emergence and with other sign languages. Although holistic signs are the prevalent structure, compounding seems to be emerging. At this stage of emergence, OSV seems to be the predominant syntactic structure of LGSTP. Yet the data suggest that new signers exhibit difficulties in syntactic constructions with two arguments.
OMTools: a software package for visualizing and processing optical mapping data
Authors: Leung Alden King-Yung , Jin Nana , Yip Kevin Y , Chan Ting-Fung 
Published: May 2017

Abstract

Summary
Optical mapping is a molecular technique capturing specific patterns of fluorescent labels along DNA molecules. It has been widely applied in assisted-scaffolding in sequence assemblies, microbial strain typing and detection of structural variations. Various computational methods have been developed to analyze optical mapping data. However, existing tools for processing and visualizing optical map data still have many shortcomings. Here, we present OMTools, an efficient and intuitive data processing and visualization suite to handle and explore large-scale optical mapping profiles. OMTools includes modules for visualization (OMView), data processing and simulation. These modules together form an accessible and convenient pipeline for optical mapping analyses.

Availability and implementation
OMTools is implemented in Java 1.8 and released under a GPL license. OMTools can be downloaded from https://github.com/aldenleung/OMTools and run on any standard desktop computer equipped with a Java virtual machine.

Supplementary information
Supplementary data are available at Bioinformatics online.
Religious Heterogamy and Partnership Quality in Later Life
Authors: Schafer Markus H , Kwon Soyoung 
Published: May 2017

Abstract

Objectives
Prior research points to the importance of couple-level religious similarity for multiple dimensions of partnership quality and stability but few studies have investigated whether this association holds for older couples.

Method
The current article uses dyadic data from the National Social Life, Health, and Aging Project (NSHAP), a representative sample of 953 individuals age 62–91 plus their marital or cohabiting partners. We use modified actor-partner interdependence models.

Results
Religious service heterogamy predicted lower relationship happiness and satisfaction. Both associations were partially explained by the fact that religiously dissimilar partners report relatively little free time in joint activity. Further, religiously heterogamous couples had less frequent sex and engaged in less nonsexual touch than their more similar counterparts.

Conclusions
Taken together, results attest to the ongoing importance of religious similarity—service attendance, in particular—for partnership quality in late life. Future research is needed to more fully examine which mechanisms account for these patterns.
The Kinetics of Reversible Hyaluronic Acid Filler Injection Treated With Hyaluronidase
Authors: Juhász Margit L.W. , Levin Melissa K. , Marmur Ellen S. 
Published: May 2017

BACKGROUND
Hyaluronidase is an enzyme capable of dissolution of hyaluronic acid (HA). There is a lack of evidence-based research defining time- and concentration-dependent reversal of HA filler using hyaluronidase.

OBJECTIVE
To explore the efficacy of different concentrations of hyaluronidase in digesting commercially available HA-based reversible fillers—Belotero Balance (BEL), Juvederm Ultra XC (JUVXC), Juvederm Ultra Plus (JUVX+), Juvederm Voluma XC (JUVV), Restylane-L (RESL), Restylane Silk (RESS), and Perlane/Restylane Lyft (RESLYFT).

MATERIALS AND METHODS
This was a blinded randomized study involving 15 participants. Participants received HA filler injection into their back, followed by no secondary injection, or injection with normal saline, 20 or 40 units of hyaluronidase. Using a 5-point palpation scale, the degradation of HA filler was monitored over 14 days.

RESULTS
In the authors' study, there is a significant decrease in HA filler degradation using 20 and 40 units of hyaluronidase compared with no secondary injection or normal saline. There is no significant difference in HA filler dissolution when comparing 20 to 40 units of hyaluronidase.

CONCLUSION
Lower concentrations of hyaluronidase may be just as effective as higher concentrations to degrade HA filler in situations where the reversal of cutaneous augmentation with HA filler arises.
Seroprevalence of Hepatitis A Twelve Years After the Implementation of Toddlers’ Vaccination
Authors: Bassal Ravit , Weil Merav , Cohen Daniel , Sofer Danit , Mendelson Ella , Shohat Tamy 
Published: May 2017

Background:
In 1999, Israel became the first country to introduce an inactivated hepatitis A vaccine into its national childhood vaccination program. The objective of the present study was to evaluate the seroprevalence of hepatitis A virus antibodies in the Israeli population before and after the introduction of the program.

Methods:
A cross-sectional serosurvey using the National Serum Bank was conducted on 1883 and 2027 serum samples collected before and after introduction of the vaccine, respectively. Serologic tests for the presence of hepatitis A IgG antibodies were performed using an automated enzyme-linked fluorescent assay.

Results:
The age-adjusted seroprevalence rates of hepatitis A virus antibodies before implementation of hepatitis A vaccination program were 47.1% [95% confidence interval (CI): 44.7%–49.5%] among Jews and 82.8% (95% CI: 79.6%–85.9%) among Arabs, increasing 12 years after to 67.4% (95% CI: 64.7%–70.0%) and 88.2% (95% CI: 86.1%–90.2%), respectively.

Conclusions:
The seropositivity rate among Jews and Arabs increased significantly among the cohorts included in the program. However, among Jews, a significant increase in seropositivity was also detected among age groups not included in the vaccination program. The decrease in the incidence of hepatitis A in Israel is a consequence of high vaccine uptake, persistent seropositivity rates after vaccination and the considerable number of people vaccinated beyond the program.
Isolation of Xanthobacter Species and Bordetella trematum in a Patient With Polymicrobial Peritonitis
Authors: Tena Daniel , Medina María José , Sáez-Nieto Juan Antonio 
Published: May 2017

Abstract
We describe a case of peritonitis secondary to perforated appendicitis in which Xanthobacter species and Bordetella trematum were isolated from the peritoneal fluid associated with Klebsiella pneumoniae. Species of the genus Xanthobacter have never been isolated from human samples to date, and human infections caused by B. trematum are very rare. The patient was cured after surgery and treatment with piperacillin/tazobactam and ciprofloxacin. The clinical significance of Xanthobacter species and B. trematum remains unclear in our case. Further studies would be necessary to know the pathogenicity of these bacteria in human infections.
Oritavancin for the Treatment of Daptomycin Nonsusceptible Vancomycin-Resistant Enterococci Osteomyelitis
Authors: Foster Rachel A. , Philavong Kingsavanh Paul , Weissman Sharon , Tang Xiaonan , Bookstaver P. Brandon 
Published: May 2017

Abstract
Vancomycin-resistant enterococci (VRE) are a growing cause of health care–associated infections globally, and limited treatment options exist for invasive VRE infections. Daptomycin is commonly used with modest success in the treatment of deep-seated infections secondary to VRE; however, there is concern for the emergence of daptomycin nonsusceptible VRE, especially during protracted courses, as required in osteomyelitis. We report the clinical and microbiologic success of a once-weekly, 6-week course of oritavancin with therapeutic drug monitoring in the treatment of daptomycin nonsusceptible VRE osteomyelitis secondary to prosthetic hip replacement. Our data suggest favorable pharmacokinetics and no treatment-related adverse events with once-weekly dosing. This report provides compelling information for future studies of prolonged oritavancin regimens in deep-seated infections.
Defining the Hook Region Anatomy of the Guinea Pig Cochlea for Modeling of Inner Ear Surgery
Authors: Lo Jonathon , Sale Phillip , Wijewickrema Sudanthi , Campbell Luke , Eastwood Hayden , O’leary Stephen John 
Published: May 2017

Hypothesis:
The aim of this study was to describe the hook region anatomy of the guinea pig cochlea to identify the optimal surgical approach for cochlear implantation and to determine what anatomical structures are at risk.

Background:
Animal studies investigating hearing loss after cochlear implantation surgery are currently constrained by the lack of a reproducible implantation model.

Methods:
Guinea pig cochleae were imaged using thin-sheet laser imaging microscopy. Images were stitched, reconstructed, and segmented for analysis. Insertion vectors were determined by tracing their paths to the outer wall and converting to Cartesian coordinates. Spherical surface and multiplane views were generated to analyze outer wall and radial forces of the insertion vector.

Results:
Thin-sheet laser imaging microscopy enabled quantitative, whole specimen analysis of the soft and bony tissue relationships of the complex cochlear hook region in any desired plane without loss of image quality. Round window or cochleostomy approaches in the anteroinferior plane avoided direct damage to cochlear structures. Cochleostomy approach had large interindividual variability of angular depth and outer wall forces but predictable radial force.

Conclusion:
The guinea pig hook region and lower basal turn have similar structural relationships to humans. Careful cochleostomy placement is essentially for minimizing cochlear trauma and for ensuring a straight insertion vector that successfully advances around the outer wall. Experiments with guinea pigs that control for the surgical approach are likely to provide useful insights into the aetiology and the development of therapies directed at postimplantation hearing loss.