bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Successful Phase Advancement and Regulatory Approval in Multiple Myeloma From Phase I Overall Response Rates
Authors: Malek Ehsan , Saygin Caner , Ye Rebecca , Covut Fahrettin , Kim Byung-Gyu , Welge Jeffrey , Meropol Neal J. , De Lima Marcos , Driscoll James J. 
Published: November 2017

Purpose Drug development in oncology is resource intensive, time consuming, and frequently unsuccessful. Here, we hypothesized that therapeutic benefit of published phase I studies of antimyeloma investigational agents was associated with advancement to phase II and future regulatory approval. Patients and Methods Seventy four phase I trials that treated patients with multiple myeloma (n = 2,408) conducted from 2004 to 2015 were analyzed to assess drug safety, efficacy, phase advancement, and regulatory approval. Results The median overall response rate (ORR) for all single-agent trials evaluated was 13.2%. However, the ORR in trials that advanced to phase II was 19%, whereas it was only 4% in trials that failed to advance. The median ORR was 23% for trials testing agents that were ultimately approved by the US Food and Drug Administration compared with only 8% for trials testing agents that were not approved (hazard ratio, 2.21; 95% CI, 2.01 to 2.61; P = .012). Importantly, the absolute number of phase I trials in multiple myeloma, but not the success rate, significantly increased over the period studied. The proportion of industry-sponsored trials also steadily increased over that same period. The ratio of initial dose to maximum tolerated dose was 0.29, suggesting that many patients were undertreated. Conclusion Investigational agents with higher ORRs in phase I trials were more likely to advance to phase II trials and achieve US Food and Drug Administration approval. Our results suggest that designing phase I trials to maximize the antimyeloma efficacy of a given compound may lead to more successful and cost-effective drug development.
Estructura óptima de capital para empresas en mercados maduros de economías emergentes: una aplicación
Authors: Herrera-Eceheverri Hernan 
Published: November 2017

En este trabajo, se utiliza el criterio de costo mínimo para determinar la estructura óptima de capital de una empresa del sector de procesamiento de alimentos en un mercado emergente (Colombia). Se abordan y armonizan varios aspectos relacionados con la política de endeudamiento para demostar que el ratio óptimo de deuda simultaneamente, maximiza el valor de la empresa y de las acciones, pero además y minimiza el costo promedio ponderado de capital (Wacc). Mediante el cálculo recursivo se determina el valor de mercado del capital propio, basado en los fundamentales de la empresa y se hace un contraste con el valor pactado en una transacción de mercado reciente. El caso permite examinar algunos de los mecanismos asociados a la teoría de la estructura de capital y aterrizarlos a resultados concretos en una empresa real, para proponer una reestrucutración del nivel de endeudamiento.
Sexual Orientation Concordance And (Un)Happiness About Births
Authors: Hartnett Caroline Sten , Lindley Lisa , Walsemann Katrina M. , Negraia Daniela V. 
Published: November 2017

AbstractCONTEXTA woman's happiness about a pregnancy and birth has implications for her child's health and her own well‐being. Sexual orientation and, particularly, the extent of concordance across its dimensions (sexual identity, behavior and attraction) may be related to happiness about these events, but research on this relationship has been lacking.METHODSData on 5,744 pregnancies ending in births among women aged 15–44 in three waves of the National Survey of Family Growth (2006–2015) were examined. Weighted linear regression models examined the relationship between sexual orientation concordance and women's happiness about a birth. Analyses also explored whether birth intention and male partnership characteristics mediated the relationship, and whether it varied by intention status.RESULTSWomen who identified as heterosexual but reported same‐sex attraction or behavior (categorized as “heterosexual‐identified discordant”) were less happy about their births than were women who were exclusively heterosexual (or “heterosexual‐identified concordant”). The difference was more than half a point on a scale of 0–10 (coefficient, –0.7). This association was partially explained by the fact that births were less likely to be intended, and that relationships with male partners were less favorable for births, among discordant than among concordant women. Moreover, the happiness gap between concordant and discordant women was larger when births were unwanted (predicted score, 4.9 vs. 4.1) than when they were intended (9.3 vs. 9.1).CONCLUSIONSTo help ensure optimal reproductive health care for all women, research should explore whether providers take into account all dimensions of individuals’ sexual orientation.
Multiple Hotspot Mutations Scanning by Single Droplet Digital PCR
Authors: Decraene Charles , Silveira Amanda B , Bidard François-Clément , Vallée Audrey , Michel Marc , Melaabi Samia , Vincent-Salomon Anne , Saliou Adrien , Houy Alexandre , Milder Maud , Lantz Olivier , Ychou Marc , Denis Marc G , Pierga Jean-Yves , Stern Marc-Henri , Proudhon Charlotte 
Published: November 2017

Abstract

BACKGROUND
Progress in the liquid biopsy field, combined with the development of droplet digital PCR (ddPCR), has enabled noninvasive monitoring of mutations with high detection accuracy. However, current assays detect a restricted number of mutations per reaction. ddPCR is a recognized method for detecting alterations previously characterized in tumor tissues, but its use as a discovery tool when the mutation is unknown a priori remains limited.

METHODS
We established 2 ddPCR assays detecting all genomic alterations within KRAS exon 2 and EGFR exon 19 mutation hotspots, which are of clinical importance in colorectal and lung cancer, with use of a unique pair of TaqMan® oligoprobes. The KRAS assay scanned for the 7 most common mutations in codons 12/13 but also all other mutations found in that region. The EGFR assay screened for all in-frame deletions of exon 19, which are frequent EGFR-activating events.

RESULTS
The KRAS and EGFR assays were highly specific and both reached a limit of detection of &lt;0.1% in mutant allele frequency. We further validated their performance on multiple plasma and formalin-fixed and paraffin-embedded tumor samples harboring a panel of different KRAS or EGFR mutations.

CONCLUSIONS
This method presents the advantage of detecting a higher number of mutations with single-reaction ddPCRs while consuming a minimum of patient sample. This is particularly useful in the context of liquid biopsy because the amount of circulating tumor DNA is often low. This method should be useful as a discovery tool when the tumor tissue is unavailable or to monitor disease during therapy.
The everlasting Sleep Dealer: Alex Rivera’s visionary mind and fantasy nightmares in present times
Authors: Rueda Carolina 
Published: November 2017

Abstract
Studies of Sleep Dealer (Rivera, 2008) have focused on its transnationality and how the film mixes the iconography of US sci-fi/cyberpunk and Latin American sociopolitics. While dialoguing with the work of other scholars, this study engages with new perspectives. First, it brings to the fore the director’s early personal experiences that later prompted his preoccupations with the presence and impact of technology in remote and rural areas of the Global South. Second, it engages in an in-depth analysis of sci-fi and dystopian motifs and symbols not wholly analysed in earlier studies that uniquely connect the actions and flows in the film with current global matters. Specific topics are nodes as dialectical images (Benjamin), the blindness of the sleep dealer (or infomaquila) workers, racism/nativism and robots as enslaved hybrid beings. Third, this study shows instances of how Rivera’s concerns regarding future ‘fantasy nightmares’ in the second decade of the twenty-first century could become (or have become) a part of life, threatening social and economic stability. Two main foci are the wall along the border with Mexico that President Trump has threatened to build and other recent political discourses in the United States, seen as abstractions or alternate realities. The article stresses the everlasting nature of Sleep Dealer as Rivera’s premonitions continue to take form in the present and, possibly, in the future.
Copycat television? Gran Hotel/Grand Hotel (2011–13) and El hotel de los secretos/The Hotel of Secrets (2015–16)
Authors: Smith Paul Julian 
Published: November 2017

Abstract
This article examines a unique case of format translation in quality television: Mexican free-to-air broadcaster Televisa’s remake in 2015–16 of a period romance-cum-mystery series originally shown by the Spanish private network Antena 3. The article begins with an account of Copycat Television, Albert Moran’s pioneering study of transnational remakes, which defines the format not as a blueprint but as a loose and expanding set of programme possibilities, and goes on to explore tensions around genre, TV ecology and audience in both countries and series. Offering a close account of production, reception and textual detail, the article demonstrates that the Mexican version of the format is at once more politicized and more romantic than the Spanish original. Finally, both productions, broadcast as they were at a time of rapid technological change in their respective audio-visual industries, attempt to create an imaginary national harmony that is projected into the past and yet adapted to new contemporary audiences.
Test- und Verifikationsverfahren für Agentensysteme – Status Quo und weitere Herausforderungen
Authors: Wassermann Erik , Fay Alexander 
Published: November 2017

Zusammenfassung
Agentensysteme gelten als aussichtsreiche Technologie, um den Herausforderungen der zunehmenden Digitalisierung –
Industrie 4.0, IoT, CPS – zu begegnen. Allerdings konnten sich Softwareagenten trotz intensiver Erforschung in den letzten
20 Jahren im industriellen Einsatz noch nicht durchsetzen. Ein Grund hierfür sind die besonderen Anforderungen bezüglich
Sicherheit, Echtzeitfähigkeit und Zuverlässigkeit beim Einsatz in industriellen technischen Systemen. Dieser Artikel gibt
einen Überblick über Test- und Verifikationsverfahren, die speziell für Agentensysteme konzipiert oder adaptiert wurden,
und beleuchtet ihre Vorteile und Beschränkungen. Er will somit Entwicklern und Testern Hilfestellung zur Auswahl
geeigneter Verfahren geben. Damit sollen die weitere Etablierung von Agentensystemen in der industriellen Praxis gefördert
sowie weitere Forschungen angestoßen werden.
Ein agentenbasiertes Assistenzsystem zur dynamischen Zuverlässigkeitsberechnung von cyber-physischen Systemen
Authors: Jazdi-Motlagh Nasser , Marks Philipp , Aivaliotis Aristides , Weyrich Michael 
Published: November 2017

Zusammenfassung
Bei der Bestimmung der Zuverlässigkeit von cyber-physischen Systemen müssen neue Ansätze und Konzepte entwickelt werden,
die den Anforderungen an die neuen Technologien gerecht werden. Neben der Möglichkeit, zur Laufzeit erfasste Daten, die
durch die Vernetzung von Komponenten zur Verfügung stehen, zur genaueren Berechnung der Zuverlässigkeit zu verwenden,
stellt insbesondere die dynamische Systemstruktur von cyber-physischen Systemen, die zum Zeitpunkt der Systementwicklung
noch nicht bekannt ist, Herausforderungen und nutzbare Potenziale für die Zuverlässigkeitsanalyse dar. Der vorliegende
Beitrag präsentiert ein Konzept zur dynamischen Zuverlässigkeitsberechnung mithilfe eines Agentensystems. Dabei wird die
klassischerweise oft als konstant angenommene Ausfallrate in drei zeitabhängige Bestandteile zerlegt, um beispielsweise
den Einfluss der menschlichen Zuverlässigkeit in die Berechnung mit aufzunehmen. Mithilfe von Software-Agenten werden die
erforderlichen Informationen zur Berechnung der Teilausfallraten ermittelt. Anhand eines Prototyps wird der Einfluss
dynamischer Einflussgrößen auf die Zuverlässigkeit eines Systems gezeigt.
Evaluating Security Research Support: The Case of Czech Security Research Programme 2010–2015
Authors: Čadil Vladislav , Moravec Luděk 
Published: November 2017

Abstract
Based on a case study of the ex-post evaluation of the programme VG-Security Research 2010–2015 this paper aims to present a possible way of the ex-post evaluation of security research programmes, and to highlight some aspects that must be taken into account in the evaluation process. It examines limits of application of the Basic Principles of Elaboration and Evaluation of Programmes and Groups of Grant Projects in Research, Development and Innovation. The limits follow from the emphasis on the summative nature of the evaluation, which combines a range of indicators that relates to a wide range of programme features. However, in the case of security research, these are rather of secondary importance or no relevance to an assessment of the success of the programme and obtaining feedback on the programme implementation for the needs of qualified learning from experience at levels of programme management and programme formulation.
Informationswissenschaft in der Urbanistik
Authors: Stock Wolfgang G. , Barth Julia , Fietkiewicz Kaja J. , Gremm Julia , Hartmann Sarah , Henkel Maria , Ilhan Aylin , Mainka Agnes , Meschede Christine , Peters Isabella 
Published: November 2017

ZusammenfassungZeitgenössische und zukünftige Städte der Wissensgesellschaft werden oft als „smarte Städte“, „digitale Städte“ oder „ubiquitäre Städte“, „Wissensstädte“ und „kreative Städte“ bezeichnet. Die informationelle Urbanistik umfasst alle Aspekte von Information und (implizitem wie explizitem) Wissen in Hinblick auf städtische Regionen. „Informationelle Stadt“ (oder „smarte Stadt“ im weiteren Sinne) ist ein Sammelbegriff, der die unterschiedlichen Trends der informationsbezogenen Stadtforschung vereint. Die informationelle Stadtforschung ist ein interdisziplinäres Unternehmen, das einerseits Informatik und Informationswissenschaft sowie andererseits Stadtforschung, Stadtplanung, Architektur, Stadtökonomie und Stadtsoziologie vereint. In diesem Artikel präsentieren wir einen konzeptionellen Rahmen für die Forschung zu informationellen Städten. Dieses Framework besteht aus sieben Bausteinen, nämlich Informations- und Wissensinfrastrukturen, Wirtschaft, Politik (eGovernance) und Verwaltung (eGovernment), Räume (Räume der Ströme und Räume der Plätze), Standortfaktoren, das Informationsverhalten der Menschen und die Problembereiche.
Lethal Subarachnoid and Intracerebral Haemorrhage Associated with Temporal Arteritis. A Case Report
Authors: Gál Réka , Bălaşa Rodica , Bajkó Zoltán , Maier Smaranda , Simu Iunius , Bălaşa Adrian 
Published: November 2017

Abstract
Giant cell arteritis is a systemic inflammatory vasculitis, typically involving the superficial temporal arteries, but with possible ischemic and hemorrhagic cerebrovascular complications.
The case is reported of a patient with a clinical picture of giant cell arteritis, who had multiple occupational exposures to various infectious agents.
His initial favourable progress was followed by an atypical outcome. Despite immunosuppressive treatment, he developed fatal subarachnoid and intracerebral haemorrhages, possibly due to rupture of a microaneurysm of the posterior cerebral artery.
Correlations between Chronological Ages and Dental Ages on a Group of Children with Down Syndrome
Authors: Chelărescu Simina , Bica Cristina 
Published: November 2017

Abstract

Background: The number of studies on oral complications in children with Down syndrome is substantial, but they are focused rather on the prevalence of dental caries, periodontal disease, and hypodontia. The relationship between Down syndrome and dental eruption has been rarely approached. The causes of delayed eruption in children with Down syndrome are incompletely elucidated due to the incomplete identification of the factors that intervene in the physiological process of dental eruption.

Aim of the study: To evaluate the correlation between Down syndrome and the delayed eruption of permanent teeth, in relation to the chronological age, in this category of patients.

Material and methods: The study group included 94 children with mixed dentition, of ages between 6 and 12 years: 36 children with Down syndrome and 58 healthy children. Clinical and radiological examinations were performed, focusing on the relation between dental age and chronological age.

Results: The presence of Down syndrome in children has a significant influence (p <0.001) on the delayed eruption of permanent teeth, considering the chronological age, compared to healthy children. The weighted average of this delay in our study group was 1.27.

Conclusions: It is necessary to monitor children with Down syndrome for an extended period of time, in order to ensure a high quality of life and to optimize their health as much as possible.
Supralevator Total Pelvic Exenteration Without Colostomy — Case Report
Authors: Botoncea Marian , Varlam Claudiu Molnar , Chiujdea Adrian , Molnar Călin 
Published: November 2017

Abstract

Background: Pelvic exenteration is an ultra-radical surgical procedure described by Brunschwig in 1948, which attempts to surgically cure patients with recurrent pelvic cancer after radiotherapy. Several variants of pelvic exenteration are described that allow a more limited or extensive resection, depending on the stage of the disease.

Case report: We report the case of a 54-year-old woman, who was diagnosed with a tumoral rectovaginal fistula after a recurrent cervical cancer that had been treated with a total hysterectomy with bilateral adnexectomy and a left percutaneous nephrostomy, as well as interaortocaval lymph node resection. The patient had undergone a supralevator total pelvic exenteration with pelvic and interaortocaval lymphadenectomy. The reconstruction process included right ureterostomy, left nephrostomy, and colocutaneous anal anastomosis (Parks procedure).

Conclusions: Supralevator total pelvic exenteration provides hope for cure in patients with pelvic malignancies that reappear after radiotherapy. The restoration of the digestive tract and avoiding colostomy with a colocutaneous anastomosis increases the quality of life in these cases.
Cardiac Magnetic Resonance and Myocardial Viability: Why Is It so Important?
Authors: Rodean Ioana , Beganu Elena , Hodas Roxana , Himcinschi Elisabeta , Bordi Lehel , Benedek Theodora 
Published: November 2017

Abstract
For a better assessment of ischemic heart diseases, myocardial viability should be quantified. Current studies underline the importance and the evolution of several techniques and methods used in the evaluation of myocardial viability. Taking into account these considerations, the aim of this manuscript was to present the recent points of view regarding myocardial viability and its clinical significance in patients with ischemic cardiomyopathies and left ventricular dysfunction. On the other hand, the manuscript points out the role of magnetic resonance imaging (MRI), one of the most useful noninvasive imaging techniques, in the assessment of myocardial viability. By comparing the advantages and disadvantages of cardiac MRI, its usefulness can be better appreciated by the clinician. In the following years, it is considered that MRI will be an indispensable imaging tool in the assessment of ischemic heart disease, guiding interventions for revascularization and long-term risk stratification in patients with stable angina or myocardial infarction.
Magnetic Resonance Imaging in Myocardial Fibrosis Related to Ischemic Events
Authors: Himcinschi Elisabeta , Beganu Elena , Bordi Lehel , Hodas Roxana , Benedek Theodora 
Published: November 2017

AbstractGiven the higher amount of detail it offers, the use of magnetic resonance (MR) in the field of cardiology has increased, thus leading to a decrease in the use of invasive and irradiating methods for diagnosing various cardiovascular disorders. The only precautions for MR imaging are metallic implants and advanced-stage chronic kidney disease. For the acquisition of clear and dynamic myocardial images, methods such as spin echo imaging for anatomical description, steady-state free precession imaging for the assessment of ventricular cavity size and function, flow velocity encoding for blood flow measurements, radiofrequency tagging for dynamics, and even spectroscopy for metabolism evaluation are used. Cardiac magnetic resonance (CMR) is considered the gold standard imaging method for the anatomical characterization of the heart and obtaining information related to myocardial dynamics. In case of ischemic events, CMR is used for a detailed description of the necrotic area and the complications, and for tracking the ventricular remodeling. By administrating a contrast agent (gadolinium), the difference between sub-endothelial and transmural infarctions can be distinguished, highlighting even microvascular lesions responsible for the extension of the necrosis. The assessment of the dynamics of ventricular remodeling and viability through late gadolinium enhancement (LGE) technology highlights the area of fibrosis and the occurrence of late complications.
Acute Thrombotic Coronary Occlusion in a Patient with Coronary Artery Anomaly
Authors: Beganu Elena , Himcinschi Elisabeta , Hodas Roxana , Cernica Daniel , Rodean Ioana 
Published: November 2017

Abstract
Patients with coronary artery anomalies are more susceptible to develop acute thrombotic coronary occlusions due to the abnormal anatomy of these arteries and the disturbance of the pathophysiological mechanisms that lead to an accelerated atherosclerosis development. The following article presents the case of a 64-year-old female patient diagnosed with anterior ST-segment elevation myocardial infarction. The patient underwent primary percutaneous coronary intervention, which revealed the absence of the right coronary artery and separated origins of the left anterior descending artery and the left circumflex artery from the aorta.