bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ursodeoxycholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein
Authors: Mohamed Anis Syamimi , Hanafi Noorul Izzati , Sheikh Abdul Kadir Siti Hamimah , Md Noor Julina , Abdul Hamid Hasani Narimah , Ab Rahim Sharaniza , Siran Rosfaiizah 
Published: October 2017

In hepatocytes, ursodeoxycholic acid (UDCA) activates cell signalling pathways such as p53, intracellular calcium ([Ca2+]i), and sphingosine‐1‐phosphate (S1P)‐receptor via Gαi‐coupled‐receptor. Recently, UDCA has been shown to protect the heart against hypoxia‐reoxygenation injury. However, it is not clear whether UDCA cardioprotection against hypoxia acts through a transcriptional mediator of cells stress, HIF‐1α and p53. Therefore, in here, we aimed to investigate whether UDCA could protect cardiomyocytes (CMs) against hypoxia by regulating expression of HIF‐1α, p53, [Ca2+]i, and S1P‐Gαi‐coupled‐receptor. Cardiomyocytes were isolated from newborn rats (0‐2 days), and hypoxia was induced by using cobalt chloride (CoCl2). Cardiomyocytes were treated with UDCA and cotreated with either FTY720 (S1P‐receptor agonist) or pertussis toxin (PTX; Gαi inhibitor). Cells were subjected for proliferation assay, beating frequency, QuantiGene Plex assay, western blot, immunofluorescence, and calcium imaging. Our findings showed that UDCA counteracted the effects of CoCl2 on cell viability, beating frequency, HIF‐1α, and p53 protein expression. We found that these cardioprotection effects of UDCA were similar to FTY720, S1P agonist. Furthermore, we observed that UDCA protects CMs against CoCl2‐induced [Ca2+]i dynamic alteration. Pharmacological inhibition of the Gαi‐sensitive receptor did not abolish the cardioprotection of UDCA against CoCl2 detrimental effects, except for cell viability and [Ca2+]i. Pertussis toxin is partially effective in inhibiting UDCA protection against CoCl2 effects on CM cell viability. Interestingly, PTX fully inhibits UDCA cardioprotection on CoCl2‐induced [Ca2+]i dynamic changes. We conclude that UDCA cardioprotection against CoCl2‐induced hypoxia is similar to FTY720, and its actions are not fully mediated by the Gαi‐coupled protein sensitive pathways. Ursodeoxycholic acid is the most hydrophilic bile acid and is currently used to treat liver diseases. Recently, UDCA is shown to have a cardioprotection effects; however, the mechanism of UDCA cardioprotection is still poorly understood. The current data generated were the first to show that UDCA is able to inhibit the activation of HIF‐1α and p53 protein during CoCl2‐induced hypoxia in cardiomyocytes. This study provides an insight of UDCA mechanism in protecting cardiomyocytes against hypoxia.
An optical coherence tomography study of neointimal morphology and strut coverage at different time intervals from implantation of biodegradable polymer‐coated sirolimus‐eluting stents
Authors: Legutko Jacek , Gil Robert J. , Buszman Pawel E. , Kaluza Grzegorz L. , Mintz Gary S. , Roleder Tomasz , Krol Marek , Wojdyla Roman , Pawlowski Tomasz , Brzezinski Michal , Kondys Marek , Skwarna Bartosz , Jakala Jacek , Zasada Wojciech , Partyka Lukasz , Dudek Dariusz 
Published: October 2017

AbstractObjectivesThe aim of the study was to capture the evolution of neointima after implantation of a biodegradable polymer–coated, sirolimus–eluting, cobalt–chromium coronary stent system (BP‐DES).BackgroundOptical coherence tomography (OCT) suggests that in‐stent neointimal morphology influences clinical outcomes after DES implantation.MethodsSixty patients treated with single BP‐DES implantation were examined by quantitative coronary angiography (QCA) and OCT at 3, 6, and 12‐month follow‐up.ResultsMedian late lumen loss by QCA (mm) was 0.04 (IQR 0, 0.08), 0.17 (IQR 0, 0.32), and 0.14 (IQR 0.07, 0.31) at 3, 6, and 12‐month follow‐up respectively (P = 0.03). OCT cross‐section multilevel analysis showed uncovered struts in 3.90%, 1.78%, and 0.02% of struts respectively (P = 0.03). The corresponding malapposition rates were 0.12%, 0.04%, and 0%. Lipid‐rich neointima was observed only at 12‐month follow‐up in one restenotic lesion (0.77% cross‐sections) that was accountable for the only target vessel revascularization. The homogeneous pattern was prevalent at all three time points, but its incidence displayed an upward trend (3 months: 59%; 6 months: 71%; 12 months: 88%) despite no difference in neointimal volume between 6 and 12 months. Conversely, a trend could be observed of decreasing incidence of heterogeneous pattern as the follow‐up length increased.ConclusionsIn this study of a single‐type BP‐DES, the majority of stent struts were covered within 3 months from implantation. While the quantitative neointimal accumulation plateaued at 6 months with no further significant increase beyond 6 months, the neointima continued to evolve qualitatively and mature along with better strut coverage between 6 and 12 months after implantation.
High Electronic Conductivity and Air Stability of Ultrasmall Copper‐Metal Nanoparticles Supported on Pyridine‐Based Polybenzimidazole Carbon Nanotube Composite
Authors: Hafez Inas H. , Berber Mohamed R. , Fujigaya Tsuyohiko , Nakashima Naotoshi 
Published: October 2017

AbstractThe development of synthetic methods of copper nanoparticles (Cu‐NPs) on conductive supports is very challenging and receives much attention. Here, we describe a novel technique to grow stable and uniform metallic Cu‐NPs homogeneously on the surface of pristine multiwalled carbon nanotube (MWNTs) catalyst support physically functionalized with a pyridine‐based polybenzimidazole (PyPBI) polymer that acts as a ligand to capture the Cu‐NPs. Cu‐metal nanoparticles with a particle size of 5.0±0.5 nm were obtained on the surface of MWNTs with homogenous and uniform distribution. The newly prepared Cu‐NPs show a remarkably enhanced air stability and electrical conductivity, compared to the current state of the art Cu‐NPs, over 20 days and 500 potential cycles, respectively, with a limited degradation rate of Cu‐metallic state. The PyPBI polymer plays an essential role in the stability of Cu‐NPs on the surface of MWNTs through coordination with PyPBI, suppressing the Cu‐degradation process, which usually decreases the Cu application efficiency. Accordingly, the prospects of applications of the present Cu‐NPs composite are excellent.
Templated Synthesis of Nickel−Iron Layered Double Hydroxide for Enhanced Electrocatalytic Water Oxidation: Towards the Development of Non‐Precious‐Metal Catalysts
Authors: Yadav Dharmendra Kumar , Ganesan Vellaichamy , Sonkar Piyush Kumar , Gupta Rupali 
Published: October 2017

AbstractLayered double hydroxides (LDHs) have recently attracted intense research attention because of their applications in the development of highly active and cost‐effective electrocatalysts for the oxygen evolution reaction and in the fields of drug delivery, energy storage, for example. In this work, we report a cheap and simple route for the synthesis of nickel–iron LDH (Ni−Fe LDH) using an iron‐based metal−organic framework, Fe‐MIL‐88 as a template. The prepared Ni−Fe LDH is characterized by scanning electron microscopy, transmission electron microscopy, X‐ray photoelectron spectroscopy, Fourier‐transform infrared spectroscopy and X‐ray diffraction techniques. Ni−Fe LDH is found to be highly active and stable for water oxidation in alkaline solution as compared to commercial Pt/C. The concept of using a metal−organic framework as a structure‐directing agent to synthesize Ni−Fe LDH and the use of the material for the oxygen evolution reaction is explored for the first time.
Versatile Tailoring of NH2‐Containing Metal–Organic Frameworks with Paddle‐Wheel Units
Authors: Guo Xiang‐Guang , Zhang Zai‐Yong , Qiu Sen , Su Xiang , Wang Ya‐Bing , Sun Xiaoqi 
Published: October 2017

AbstractAn amine‐containing non‐interpenetrating pillar‐layer framework, [Zn2(dbtcb)(L1)]⋅x solvent (1), has been synthesized from Zn(NO3)2 and the ligands 1,4‐dibromo‐2,3,5,6‐tetrakis(4‐carboxyphenyl)benzene (H4DBTCB) and 2,5‐bis(4‐pyridyl)aniline (L1). The [Zn2(COO)4] secondary building units (SBUs) are bridged by DBTCB to form two‐dimensional layers that are linked by L1 ligands acting as pillars to form a three‐dimensional network. This NH2‐containing framework can undergo versatile tailoring through post‐synthetic covalent modification, solvent‐assisted linker exchange (SALE), and single‐crystal‐to‐single‐crystal (SC‐SC) transmetalation reactions. Acetamide‐functionalized [Zn2(L2)(dbtcb)]⋅xsolvent (2) could be obtained by direct synthesis from Zn(NO3)2, N‐acetyl‐2,5‐bis(4‐pyridyl)aniline (L2) and H4DBTCB. Importantly, compound 1 with pure NH2 ligands as pillars could be obtained by SALE of 2 with L1 in DMSO solution. The transmetalation reactions of 1 with CuII, NiII, and CoII were studied; inductively coupled plasma‐atomic emission (ICP) analysis revealed that 1 underwent almost complete SC‐SC transmetalation with CuII within 30 h, whereas with NiII and CoII only 70 and 80 % substitutions were achieved. Photoluminescence studies revealed that 1 and 2 display yellow‐green and UV emission, respectively, under a UV lamp. Furthermore, the photoluminescent properties could be tuned by introducing mixed pillar amino ligands L1 and L2 into the MOF to produce multivariate (MTV) MOF 3 displaying overall orange emission.
Multifaceted Supramolecular Interactions from C‐Methylresorcin[4]arene Lead to an Enhancement in In Vitro Antibacterial Activity of Gatifloxacin
Authors: Dawn Arnab , Chandra Harish , Ade‐Browne Chandra , Yadav Jagjit , Kumari Harshita 
Published: October 2017

AbstractMimicking the antibacterial activity of polyphenols in synthetic systems is an attractive approach for the development of new active pharmaceutical ingredients. Resorcinarenes represent a class of polyphenols, which have been exploited for decades for their attractive chemical scaffold suitable for forming host–guest complexes with hydrophobic guest molecules. However, the polyphenolic character of resorcinarenes, which could be a potential asset to the pharmaceutical industry, have been least exploited. The present work represents an unprecedented interplay of antimicrobial activity of resorcinarene together with its ability to interact chemically with an antibacterial drug gatifloxacin, improving the overall antibacterial activity. The chemistry and the clinical activities involved in this study were investigated simultaneously by spectroscopic techniques, as well as by in vitro measurement of antibacterial activity toward two human bacterial pathogens, a Gram‐positive pathogen Staphylococcus aureus and a Gram‐negative lung pathogen Legionella pneumophila. The initial positive result obtained from this study could revolutionize the use of synthetically modifiable resorcinarenes and their analogues in fine tuning the clinical behavior of drugs.
Li+ Ion Conductors with Adamantane‐Type Nitridophosphate Anions β‐Li10P4N10 and Li13P4N10X3 with X=Cl, Br
Authors: Bertschler Eva‐Maria , Dietrich Christian , Leichtweiß Thomas , Janek Jürgen , Schnick Wolfgang 
Published: October 2017

Abstractβ‐Li10P4N10 and Li13P4N10X3 with X=Cl, Br have been synthesized from mixtures of P3N5, Li3N, LiX, LiPN2, and Li7PN4 at temperatures below 850 °C. β‐Li10P4N10 is the low‐temperature polymorph of α‐Li10P4N10 and crystallizes in the trigonal space group R3. It is made up of non‐condensed [P4N10]10− T2 supertetrahedra, which are arranged in sphalerite‐analogous packing. Li13P4N10X3 (X=Cl, Br) crystallizes in the cubic space group
. Both isomorphic compounds comprise adamantane‐type [P4N10]10−, Li+ ions, and halides, which form octahedra. These octahedra build up a face‐centered cubic packing, whose tetrahedral voids are occupied by the [P4N10]10− ions. The crystal structures have been elucidated from X‐ray powder diffraction data and corroborated by EDX measurements, solid‐state NMR, and FTIR spectroscopy. Furthermore, we have examined the phase transition between α‐ and β‐Li10P4N10. To confirm the ionic character, the migration pathways of the Li+ ions have been evaluated and the ion conductivity and its temperature dependence have been determined by impedance spectroscopy. XPS measurements have been carried out to analyze the stability with respect to Li metal.
Structures of a Complex Hydrazinium Lead Iodide, (N2H5)15Pb3I21, Possessing [Pb2I9]5−, [PbI6]4−, and I− Ions and α‐ and β‐(N2H5)PbI3
Authors: Campbell Eric V. , Dick Brandon , Rheingold Arnold L. , Zhang Chuang , Liu Xiaojie , Vardeny Zeev V. , Miller Joel S. 
Published: October 2017

AbstractPhotovoltaic perovskites, most notably methylammonium lead triiodide, (NH3Me)PbI3, have recently attracted considerable attention, and based upon the modified “Goldschmidt” as well as a “revised” tolerance factors, hydrazinium should be able to occupy the same cation site as methylammonium, and form a cubic unit cell. The reaction of N2H5+I− with PbI2 in dimethylformamide results in three types of yellow crystals; hexagonal, needle‐like, and rod‐like, the structures of which were determined at 100 K. The hexagonal (P63/m: a=10.8906(10) Å; b=37.845(5) Å) crystals possess isolated face‐sharing octahedral [Pb2I9]5−, [PbI6]4−, and I− ions. IR spectroscopy indicates the presence of hydrogen‐bonded N2H5+ and the composition was determined by single‐crystal X‐ray diffraction, density measurements, combustion elemental analysis, and thermogravimetric analysis to be (N2H5)15Pb3I21, which is photoluminescent at 50 K, but not at room temperature. The needle and rod crystals have an orthorhombic (Pnma: a=11.1385(7) Å; b=4.4806(3) Å; c=17.6241(11) Å) and hexagonal (P63/mmc: a=8.7386(9) Å; b=8.2006(9) Å) unit cells, respectively, possessing the perovskite ABX3 composition of (N2H5)PbI3, but neither exhibits the cubic Perovskite structure type. The structures of α‐ and β‐(N2H5)PbI3 possess parallel ribbons of Pb2I4 and chains of PbI2, respectively. Strong inter‐hydrazinium hydrogen bonding due to it possessing both hydrogen bonding donor and acceptor sites (unlike NH3Me+) appear to stabilize the observed extended ribbon motif for (N2H5)15Pb3I21 and α‐(N2H5)PbI3. (N2H5)15Pb3I21 has a band‐gap‐like absorption of 2.34 eV, and both α‐ and β‐(N2H5)PbI3 have a 2.70 eV band‐gap‐like absorptions.
BER analysis and interference mitigation for GO‐OFDMA transmission
Authors: Khan Abdul Rauf , Kumar Preetam 
Published: October 2017

SummaryCarrier frequency offset (CFO) results in multiaccess interference and intersymbol interference and degrades the bit error rate performance. Mitigating the effects of CFO always burdens the receiver with respect to architecture and power. This disadvantage increases with increase in number of users. In the present work, bit error rate analysis of multiuser group orthogonal–orthogonal frequency division multiple access scheme for variable rate and single rate over pedestrian channel in the presence of CFO is presented. Through analysis, it is proved that by incorporating carrier interferometry codes in the scheme, CFO effects can be removed without burdening receiver. It is also shown by analysis that effect of CFO is rate dependent. Finally, simulation results are provided to confirm the analytical results.
Atrazine feminizes sex ratio in Blanchard's cricket frogs (Acris blanchardi) at concentrations as low as 0.1 μg/L
Authors: Hoskins Tyler D. , Boone Michelle D. 
Published: October 2017

Abstract

We exposed Blanchard's cricket frogs (Acris blanchardi) to ecologically relevant concentrations (0, 0.1, 1, and 10 μg/L) of a commercial formulation of atrazine throughout the larval period to determine effects on survival, somatic growth and development (time to metamorphosis and mass at metamorphosis), and gonadal development (sex ratio at metamorphosis and the prevalence of testicular ova in phenotypic males). We tested the following hypotheses: 1) atrazine feminizes the sex ratio, 2) atrazine increases the proportion of phenotypic males with testicular ova, and 3) atrazine differentially affects somatic growth (mass at metamorphosis) and development (time to metamorphosis) for males and females. Although the control sex ratio was male-biased, exposure to 0.1 and 10 μg/L atrazine feminized sex ratios, because these treatments produced 51 and 55% fewer males than the control, respectively. We did not observe testicular ova. Atrazine did not impact survival or metamorphosis, and we did not detect sexually dimorphic impacts on time to metamorphosis or mass at metamorphosis. However, males metamorphosed 2.3 d later than females, regardless of treatment. Sex biases in timing of metamorphosis are underexplored in anurans, but if prevalent, could have important implications for theory surrounding the impact of environmental factors on metamorphosis. Our data suggest that cricket frog sex ratios are sensitive to environmentally relevant concentrations of atrazine and that feminization in the field is likely. Environ Toxicol Chem 2018;37:427–435. © 2017 SETAC
Demic and cultural diffusion in prehistoric Europe in the age of ancient genomes
Authors: Harris Eugene E. 
Published: October 2017

AbstractAncient genomes can help us detect prehistoric migrations, population contractions, and admixture among populations. Knowing the dynamics of demography is invaluable for understanding culture change in prehistory, particularly the roles played by demic and cultural diffusion in transformations of material cultures. Prehistoric Europe is a region where ancient genome analyses can help illuminate the interplay between demography and culture change. In Europe, there is more archeological evidence, in terms of detailed studies, radiometric dates, and explanatory hypotheses that can be evaluated, than in any other region of the world. Here I show some important ways that ancient genomes have given us insights into population movements in European prehistory. I also propose that studies might be increasingly focused on specific questions of culture change, for example in evaluating the makers of “transitional” industries as well as the origins of the Gravettian and spread of the Magdalenian. I also discuss genomic evidence supporting the large role that demic expansion has played in the Neolithization of Europe and the formation of the European population during the Bronze Age.
Preparation of hydrophilic blood compatible polypropylene/pluronics F127 films
Authors: Hakani Mahsa , Haddadi‐Asl Vahid , Zargarian Seyed Shahrooz , Moghadasi Mohamad Hossein 
Published: October 2017

AbstractIn order to improve surface hydrophilicity, blood compatibility and cell‐antiadhesion of polypropylene (PP) film, polypropylene oxide (PPO)‐polyethylene oxide‐PPO used as macromolecular surface modifier through physical blending. Surface properties of blended PP/Pluronic F127 (PF127) samples were investigated by attenuated total reflection infrared spectroscopy and water contact angle measurements. Results demonstrated that PF127 migrated to the surface. Thus, mechanical properties of blended PP/PF127 samples with the aim of the revealing the effects of the presence of modifier in the bulk were investigated through differential scanning calorimetry, X‐ray diffraction, and tensile tests. The biocompatibility and hemocompatibility of modified PP films were evaluated by 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, platelet‐rich plasma, and hemolysis tests. These results showed excellent anticell and antiplatelet adhesion which deems the prepared blended films proper biomaterials. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 652–662, 2018.
Acquired factor XI deficiency and therapeutic plasma exchange
Authors: Wool Geoffrey D. , Treml Angela , Miller Jonathan L. 
Published: October 2017

AbstractCongenital factor XI (FXI) deficiency is associated with a variable bleeding phenotype. Recent reports have documented the use of therapeutic plasma exchange to rapidly and isovolumetrically increase FXI levels before invasive procedures in patients with congenital FXI deficiency.We report a case of acquired FXI deficiency in a pregnant woman with lupus. We proved that the inhibitor was an IgG, therefore potentially capable of crossing the placenta. While immune suppression eliminated detectable circulating inhibitor, the woman's FXI remained quite low. A multi‐disciplinary team was formed and therapeutic plasma exchange with 100% plasma replacement was performed when the patient went into labor, to acutely raise her FXI level and remove any potential non‐neutralizing inhibitor. The mother had a controllable level of bleeding during post‐TPE cesarean section; the baby had no bleeding and the baby's FXI levels were not overtly abnormal.Therapeutic plasma exchange in acquired FXI deficiency (or other acquired hemophilias) can both acutely isovolumetrically raise factor levels and remove any circulating inhibitor.
Regional citrate anticoagulation with calcium replacement in pediatric apheresis
Authors: Sigler Katie , Lee Ji , Srivaths Poyyapakkam 
Published: October 2017

PurposeThe objective of this retrospective analysis was to present our single‐center experience with intravenous (IV) calcium replacement and regional citrate anticoagulation in pediatric apheresis therapy with the aim of developing a standard operating procedure to minimize symptomatic hypocalcemia.MethodsWe analyzed apheresis procedures in patients <18 years of age over a 2‐year time period (Jan 2012 to Dec 2014). Procedures in tandem with other extracorporeal therapies, including continuous renal replacement therapy, extracorporeal liver support, and extracorporeal membrane oxygenation, were excluded.ResultsTwo‐hundred and six patients underwent 1176 procedures. All procedures were performed with acid citrate dextrose formula A (ACD‐A) for anticoagulation and IV calcium replacement. The majority of procedures (56.7%) were therapeutic plasma exchange (TPE). The average rate of IV calcium chloride (2.16 mg/mL of elemental calcium) was 60.4 ± 21.4 mL/h while inlet flow rate was 43.7 ± 16.3 mL/min. Patients experienced hypocalcemia in 63 of 1176 procedures (5.3%), including 48 episodes (4.1%) of hypocalcemia during apheresis treatment. Two procedures with hypocalcemia had symptoms: one slight lip twitch and one patient with abdominal pain. No hemodynamic alterations were noted in any procedure associated with hypocalcemia. Hypocalcemia was seen the least with RCE. For patients with hypocalcemia prior to the apheresis session, we used a calcium infusion running at 1.6 times the inlet flow rate.ConclusionRunning IV calcium at 1.4 times the inlet flow rate resulted in a lower incidence of hypocalcemia than reported in literature describing other approaches to apheresis. It nearly eliminated episodes of symptomatic hypocalcemia.
Improving the photo‐reduction of CO2 to fuels with catalysts synthesized under high pressure: Cu/TiO2
Authors: Camarillo Rafael , Tostón Susana , Martínez Fabiola , Jiménez Carlos , Rincón Jesusa 
Published: October 2017

AbstractBACKGROUNDIn previous studies the enhanced activity of TiO2‐based catalysts synthesized in supercritical medium for photocatalytic reduction of CO2 was proved.RESULTSIn this study, Cu/TiO2 photocatalysts were synthesized by hydrothermal methods in supercritical CO2. Two titanium precursors [titanium tetraisopropoxide and diisopropoxititanium bis(acetylacetonate)], two alcohols (ethanol and isopropyl alcohol), and one metal precursor (Cu (II) acetylacetonate) were used in the synthesis. Catalysts produced showed improved properties in comparison with the commercial reference catalyst (Degussa P‐25, Evonik).CONCLUSIONSSpecifically, it has been found that Cu/TiO2 catalysts may yield methane production rates 20 times larger than that of commercial TiO2 catalyst without diminishing CO production rate (about 5 times higher than that of commercial catalyst). This result has been mainly imputed to both the formation of oxygen vacancies during the synthesis in supercritical medium and the high capacity of copper to adsorb and activate CO2 molecules, while preventing CO molecules from reoxidation, and avoiding the competitive reaction of hydrogen formation. © 2017 Society of Chemical Industry