bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Rheology for the Prediction of Surgical Outcomes in Autologous Fat Grafting
Authors: Luan Anna , Zielins Elizabeth R. , Wearda Taylor , Atashroo David A. , Blackshear Charles P. , Raphel Jordan , Brett Elizabeth A. , Flacco John , Alyono Michael C. , Momeni Arash , Heilshorn Sarah , Longaker Michael T. , Wan Derrick C. 
Published: June 2017

Background:
Because of the abundance and biocompatibility of fat, lipotransfer has become an attractive method for treating soft-tissue deficits. However, it is limited by unpredictable graft survival and retention. Currently, little is known about the viscoelastic properties of fat after various injection methods. Here, the authors assess the effects of cannula diameter, length, and shape on the viscoelastic properties, structure, and retention of fat.

Methods:
Human lipoaspirate was harvested using suction-assisted liposuction and prepared for grafting. A syringe pump was used to inject fat at a controlled flow rate through cannulas of varying gauges, lengths, and shapes. Processed samples were tested in triplicate on an oscillatory rheometer to measure their viscoelastic properties. Fat grafts from each group were placed into the scalps of immunocompromised mice. After 8 weeks, graft retention was measured using micro–computed tomography and grafts were explanted for histologic analysis.

Results:
Lipoaspirate injected through narrower, longer, and bent cannulas exhibited more shear thinning with diminished quality. The storage modulus (G′) of fat processed with 18-gauge cannulas was significantly lower than when processed with 14-gauge or larger cannulas, which also corresponded with inferior in vivo histologic structure. Similarly, the longer cannula group had a significantly lower storage modulus than the shorter cannula, and was associated with decreased graft retention.

Conclusions:
Discrete modifications in the methods used for fat placement can have a significant impact on immediate graft integrity, and ultimately on graft survival and quality. Respecting these biomechanical influences during the placement phase of lipotransfer may allow surgeons to optimize outcomes.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, V.
Conversion for Unfavorable Intraoperative Events Results in Significantly Worse Outcomes During Laparoscopic Liver Resection
Authors: Halls Mark C. , Cipriani Federica , Berardi Giammauro , Barkhatov Leonid , Lainas Panagiotis , Alzoubi Mohammed , D’Hondt Mathieu , Rotellar Fernando , Dagher Ibrahim , Aldrighetti Luca , Troisi Roberto I. , Edwin Bjorn , Abu Hilal Mohammed 
Published: June 2017

Objective:
To investigate the risk factors for conversion during laparoscopic liver resection and its effect on patient outcome in a large cohort of patients. Additional analysis of outcomes in patients who required conversion for unfavorable intraoperative findings and conversion for unfavorable intraoperative events will be performed to establish if the cause of conversion effects outcome.

Summary Background Data:
Multiple previous studies demonstrate that laparoscopic liver surgery reduces intraoperative blood loss, hospital stay, and morbidity while maintaining comparable oncological and survival outcomes when compared with open liver resections. However, limited information is available regarding the possible sequelae of conversion to open surgery, especially with regards to cause of conversion.

Methods:
A retrospective analysis of 2861 cases from prospectively maintained databases of 7 tertiary liver centers across Europe was performed.

Results:
Neo-adjuvant chemotherapy, previous liver resection(s), resections for malignant lesions, postero-superior location, and the extent of the resection are associated with an increased risk of conversion. Patients who require conversion have longer operations with higher blood loss; a longer HDU and total hospital stay, increased frequency and severity of complications and higher 30- and 90-day mortality. Patients who had an elective conversion for an unfavorable intraoperative finding had better outcomes than patients who had an emergency conversion secondary to an unfavorable intraoperative event in terms of HDU and total hospital stay, severity of complication, and 90-day mortality.

Conclusions:
Our study highlights the risk factors for conversion and suggests that conversion for unfavorable intraoperative events is associated with worse outcomes.
Robotic Verse Laparoscopic Gastrectomy for Gastric Cancer: A Pooled Analysis of 11 Individual Studies
Authors: Duan Bo-Shi , Zhao Jian , Xie Long-Fei , Wang Yue 
Published: June 2017

Objective:
Robotic surgery is a new technique with the benefits of a 3-dimensional view, the ability to use multidegree-of-freedom forceps, the elimination of physiological tremors, and a stable camera view. The aim of this study was to evaluate the feasibility and short-term outcomes of robotic surgery for gastric cancer, compared with conventional laparoscopic surgery.

Methods:
A literature search was performed for comparative studies reporting perioperative outcomes of robotic gastrectomy (RG) and laparoscopic gastrectomy (LG). The methodological quality of the selected studies was assessed. The data were analyzed using Stata (Version 13.0) software.

Results:
Eleven studies of 3503 patients totally were included for meta-analysis. Compared with LG, RG indicated potentially favorable outcomes in terms of blood loss [weighted mean difference (WMD)=−36.50; 95% confidence interval (CI), −61.39 to −11.61], and time to oral intake (WMD=−0.28; 95% CI, −0.46 to −0.09). But RG suggested longer operative time (WMD=53.48; 95% CI, 38.84-68.12). There were no differences in terms of postoperative flatus, length of hospital stay, postoperative complications, and lymph nodes harvested (P>0.05).

Conclusions:
RG for the treatment of gastric cancer is a feasible and safe procedure in the hand of experienced laparoscopic surgeons. But the long-term outcomes between the 2 techniques need to be further examined.
DNA metabarcoding for high-throughput monitoring of estuarine macrobenthic communities
Authors: Lobo Jorge , Shokralla Shadi , Costa Maria Helena , Hajibabaei Mehrdad , Costa Filipe Oliveira 
Published: June 2017

AbstractBenthic communities are key components of aquatic ecosystems’ biomonitoring. However, morphology-based species identifications remain a low-throughput, and sometimes ambiguous, approach. Despite metabarcoding methodologies have been applied for above-species taxa inventories in marine meiofaunal communities, a comprehensive approach providing species-level identifications for estuarine macrobenthic communities is still lacking. Here we report a combination of experimental and field studies demonstrating the aptitude of COI metabarcoding to provide robust species-level identifications within a framework of high-throughput monitoring of estuarine macrobenthic communities. To investigate the ability to recover DNA barcodes from all species present in a bulk DNA extract, we assembled 3 phylogenetically diverse communities, using 4 different primer pairs to generate PCR products of the COI barcode region. Between 78 and 83% of the species in the tested communities were recovered through HTS. Subsequently, we compared morphology and metabarcoding-based approaches to determine the species composition from four distinct sites of an estuary. Our results indicate that the species richness would be considerably underestimated if only morphological methods were used. Although further refinement is required for improving the efficiency and output of this approach, here we show the great aptitude of COI metabarcoding to provide high quality and auditable species identifications in macrobenthos monitoring.
Molecular basis for the specific and multivariate recognitions of RNA substrates by human hnRNPA2/B1
Authors: Wu Baixing , Su Shichen , Patil Deepak P. , Liu Hehua , Gan Jianhua , Jaffrey Samie R. , Ma Jinbiao 
Published: June 2017

SUMMARYHuman hnRNPA2/B1 is an RNA-binding protein that plays important roles in a variety of biological processes, from mRNA maturation, trafficking and translation to regulation of gene expression mediated by long non-coding RNAs and microRNAs. hnRNPA2/B1 contains two RNA recognition motifs (RRM) that provide sequence-specific recognition of widespread RNA substrates including recently reported m6A-containing motifs. Here we determined the first crystal structures of tandem RRM domains of hnRNPA2/B1 in complex with various RNA substrates. Our structures reveal that hnRNPA2/B1 can bind two RNA elements in an antiparallel fashion with a sequence preference for AGG and UAG by RRM1 and RRM2, respectively, suggesting an RNA matchmaker mechanism during the hnRNPA2/B1 function. However, our combined studies did not observe specific binding of m6A by either the RRM domains or the full-length hnRNPA2/B1, implying that the “reader” function of hnRNPA2/B1 may adopt an unknown mechanism that remains to be characterized.
Anatomical predictors of successful prism adaptation in chronic visual neglect
Authors: Lunven Marine , Rode Gilles , Bourlon Clémence , Duret Christophe , Migliaccio Raffaella , Chevrillon Emmanuel , Schotten Michel Thiebaut de , Bartolomeo Paolo 
Published: June 2017

AbstractVisual neglect is a frequent and disabling consequence of right hemisphere damage. Previous work demonstrated a probable role of posterior callosal dysfunction in the chronic persistence of neglect signs. Prism adaptation is a non-invasive and convenient technique to rehabilitate chronic visual neglect, but it is not effective in all patients. Here we aimed to assess the hypothesis that prism adaptation improves left neglect by facilitating compensation through the contribution of the left, undamaged hemisphere. We assessed the relationship between prism adaptation effects, cortical thickness and white matter integrity in a group of 14 patients with unilateral right-hemisphere strokes and chronic visual neglect. Results showed that patients who benefitted from prism adaptation had thicker cortex in temporo-parietal, prefrontal and cingulate areas of the left, undamaged hemisphere. Additionally, these patients had a higher fractional anisotropy value in the body and genu of the corpus callosum. Results from normal controls show that these callosal regions connect temporo-parietal, sensorimotor and prefrontal areas. Finally, shorter time intervals from the stroke tended to improve patients’ response to prism adaptation. We concluded that prism adaptation may improve left visual neglect by promoting the contribution of the left hemisphere to neglect compensation. These results support current hypotheses on the role of the healthy hemisphere in the compensation for stroke-induced, chronic neuropsychological deficits, and suggest that prism adaptation can foster this role by exploiting sensorimotor/prefrontal circuits, especially when applied at early stages post-stroke.
Collaborative facilities management model: Sri Lankan perspective
Authors: Weerasinghe R.P.N.P. , Sandanayake Y.G. 
Published: June 2017

Purpose
The purpose of this paper is to develop a collaborative facilities management (CFM) model incorporating facilities management (FM) functions that can be shared and performed collaboratively by two or more organisations to enhance the performance of FM functions of collaborating organisations.

Design/methodology/approach
A critical literature review followed by a preliminary investigation was used to identify main categories of FM functions that can be performed collaboratively and dimensions that affect FM collaboration. Subsequently, a detailed list of FM functions that can be performed collaboratively under eight different contexts based on three dimensions identified through observations, document reviews and in-depth interviews with experts who have experience in each context.

Findings
The paper introduces a novel concept of CFM to share utility/infrastructure facilities, facility services and information by two or more organisations to maintain, improve, adapt and ensure functionality of the built environments of the collaborating organisations. The study identified core business, geographical location and ownership as the key dimensions that affect CFM concept. The outcome of the study, which is CFM model, proposes FM functions that can be performed collaboratively and benefits of collaborating utilities/infrastructure facilities, facility services and information under the aforementioned key dimensions to create a win-win situation for the organisations.

Practical implications
The paper highlights the FM functions that can be performed collaboratively in order to provide favourable solutions for operational issues faced by facilities managers, while optimising the FM performance of the organisations.

Originality/value
The CFM model offers original insights to the FM functions that can be shared and performed collaboratively by organisations under different contexts to optimise the FM performance.
Effect of perceptual differences on consumer purchase intention of natural functional food
Authors: Rezai Golnaz , Teng Phuah Kit , Shamsudin Mad Nasir , Mohamed Zainalabidin , Stanton John L. 
Published: June 2017

Purpose
The concept of functional foods is not new to the Malaysian people. Functional foods as traditional medicine have made tremendous contributions over the past couple of centuries. The growth in the economy, coupled with a strong desire among the Malaysian consumers to maintain a healthy lifestyle has made functional foods an alternative medicine among the populace. Although the consumption of functional foods is increasing in Malaysia, relatively little is known about the factors which affect consumer purchase intention toward natural functional foods. The purpose of this paper is to determine Malaysian consumer intention to purchase natural functional foods.

Design/methodology/approach
A survey was conducted in the country where 2,004 household were interviewed using structured questionnaires. The theory of reasoned action (TRA) and health belief model were adopted and modified in this study. Descriptive statistics and structural equation modeling were used to analyze the collected data.

Findings
The results have shown that the data set was normal, valid and reliable. Attitude has a partial mediating effect on perceived barriers, perceived susceptibility and perceived benefits which influence consumer intention to purchase natural functional foods. Nevertheless attitude had no mediation effect on subjective norms for consumers to form their intention to purchase natural functional foods. In other word, subjective norms had a direct influence on consumer intention to purchase natural functional foods.

Research limitations/implications
The main concern of this paper is about the factors which affect consumer purchase intention toward natural functional foods. However the results from this paper are limited in terms of determining consumer purchasing behavior for natural functional foods.

Originality/value
The paper expands on the TRA and health belief model to examine the factors which influence Malaysian consumer purchase intention toward natural functional foods.
The multicultural experience of international students in Portugal: a narrative approach
Authors: Nada Cosmin Ionut , Araújo Helena Costa 
Published: June 2017

PurposeThe aim of this paper is to explore qualitatively and holistically the experience of international students in the context of Portuguese higher education. This paper interrogates the potential that an experience abroad provides for multicultural learning and for enhancing interaction between students with different cultural backgrounds.Design/methodology/approachTo provide depth to the understanding of their experiences abroad, the narratives of 12 international students in Portugal were constructed and analysed interpretatively. The findings presented in this paper result from a solid set of data based on 41 interviews with an average duration of two hours each.FindingsRegarding students’ levels of multicultural contact, the findings presented in this paper are not consistent with previous research literature which indicates a tendency for segregation among international and local students. Aside from one exception, all the interviewed students were rather comfortable to interact with their local peers and even established meaningful friendships with them. Concerning students’ learning throughout the sojourn, the findings indicate that the experience of living in a different country provides numerous opportunities for multicultural learning.Research limitations/implicationsEven though the findings suggest that multicultural learning is part of international students’ lives, it is beyond the scope of this paper to identify institutional strategies to further support students’ learning.Originality/valueThe study adds to knowledge production in the field of multicultural education by bringing data from Portugal, a country seldom approached in the research literature.
International education management
Authors: Riad Shams S.M. 
Published: June 2017

Purpose
International students, who have a non-English speaking background (NESB), encounter many difficulties, in comparison to their local fellows of an English-speaking country. Literature demonstrates that leveraging various relational perspectives in a multicultural teaching environment has favourable implications to manage the NESB international students’ academic experience. Based on the observation and introspection approaches and a relevant literature review in relationship management, an ethnographic analysis is conducted to realise how such relational perspectives can be nurtured, in a way that the NESB international students expect and accept in a foreign country.

Design/methodology/approach
A literature review in relationship management and an ethnographic analysis based on observation and introspection methods was conducted.

Findings
Findings show that universities could assist the NESB international students by designing, delivering and monitoring innovative teaching and learning approaches and taking care of the associated academic and non-academic issues of the students, while leveraging the social, psychological and academic relational perspective(s).

Originality/value
Leveraging relational perspectives offers global implications. The implications of relational perspectives can be used from any setting. However, the relational appeal should be focused on the presented circumstances of a targeted setting only (e.g. the issues of a particular multicultural classroom).
Cycology – what has been learnt from previous real estate cycles?
Authors: Durkin Simon 
Published: June 2017

Purpose
The purpose of this paper is to look at the lessons learnt from the previous real estate cycles based on a sample of investors, occupiers and academics and seek to understand the practical challenges the industry faces in the current cycle.

Design/methodology/approach
The paper summarises the results of qualitative research and interviews conducted and analysed by BNP Paribas Real Estate and Ipsos MORI.

Findings
The paper considers the crisis of 2008, its impact on performance, lessons learnt by the industry as a result and the future challenges. Whilst the industry felt well prepared to withstand future uncertainty and change, there was concern that subsequent generations of industry professionals will not be well equipped to deal with the pace and magnitude of change.

Practical implications
This is a practical study that seeks to place a greater emphasis on the drivers of market sentiment rather than focussing on quantitative forecasts.

Originality/value
There is much attention given to quantitative property market forecasts; however, there seems to be little appreciation of the need to evolve our process in today’s fast paced, structurally changing market which will behave differently to how it has in the past. Economic forecasts have received much criticism recently and these provide the basis for property market forecasts. The consideration of sentiment and the qualitative aspect of the future drivers of performance have never been so critical.
Implementation of lean supply chain: an empirical research on the effect of context
Authors: Tortorella Guilherme Luz , Miorando Rogério , Tlapa Diego 
Published: June 2017

Purpose
The purpose of this paper is to empirically investigate the effect of a set of contextual variables on the implementation of lean supply chain (LSC) practices. The authors do that by investigating one main research question: “how do the contextual variables (i.e. plant size, supply chain level, level of onshore suppliers and age of the LM initiative) influence on the degree of adoption of LSC practices?”

Design/methodology/approach
To this end, the authors collected data from 115 companies from different sectors located in Southern Brazil. Data collected was analyzed by means of multivariate techniques. The authors tested if the frequency of observations for each contextual variable was associated to the implementation levels of the LSC practices.

Findings
The evidences suggest that supply chain context significantly impacts the likelihood of implementing LSC practices. In particular, the influence of tier level, plant size and larger experience in implementing LM seems to be substantial across a wide mix of practices. On the other hand, results indicate that contexts in which companies are still beginners at the lean journey and their level of onshore suppliers appear to be less pervasive than previous empirical researches imply.

Originality/value
The implementation of LSC practices entails a different business model, in which improved profits arise from the cooperation rather than bargaining or imposing power over supply chain partners. However, not all organizations should implement the same set of practices, since the adoption of any specific management practice depends upon a set of contextual variables. The understanding of the relationship between the level of adoption of LSC practices and the contextual variables helps to anticipate occasional difficulties and sets the proper expectations along the implementation.