bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergism between two amphenicol of antibiotics, florfenicol and thiamphenicol, against Staphylococcus aureus
Authors: Wei C.‐F. , Chang S.‐K. , Shien J.‐H. , Kuo H.‐C. , Chen W.‐Y. , Chou C.‐C. 
Published: February 2016

Synergistic effects between the same class of antibiotics are rarely reported. In the current study, two amphenicols, namely florfenicol and thiamphenicol, exhibited both in vitro and in vivo synergism against clinical isolates of Staphylococcus aureus from chickens, cattle and pigs. Checkerboard assays on 21 S. aureus isolates showed that in 80 per cent of methicillin‐susceptible S. aureus (MSSA) and 82 per cent of methicillin‐resistant S. aureus (MRSA) isolates tested, the minimal inhibitory concentration (MIC) of florfenicol could be reduced by 75 per cent (1/4 MIC) or more (up to 1/16 MIC) when combined with 1/2 MIC of thiamphenicol to exhibit antimicrobial activity comparable to the respective drugs at original strength (1×MIC). A synergistic effect (fractional inhibitory concentration index ≤0.5 or ≥2‐log10 decrease in colony‐forming unit/ml in time‐kill study) was evident against 30 per cent of MSSA and 45 per cent of MRSA strains tested. A study in mice revealed that the florfenicol/thiamphenicol combination at reduced dosages provided sufficient protection against S. aureus challenge. The possible mechanism warrants further study but likely includes the facilitated uptake of thiamphenicol via florfenicol action, and this facilitation was not limited to amphenicol class. The present study may offer new strategy for combination therapy and provide potential alternatives for effective treatment against S. aureus infections.
Morphodynamics and facies architecture of streamflow-dominated, sand-rich alluvial fans, Pleistocene Upper Valdarno Basin, Italy
Authors: Ghinassi Massimiliano , Ielpi Alessandro 
Published: February 2016

Abstract

The overwhelming documentation of coarse-grained alluvial fans dominated by mass flow contrasts with the scarce accounts of finer grained, traction-dominated alluvial fans. To fill this gap, we present sedimentological and architectural data from a set of sand-rich, streamflow-dominated Pleistocene fans flanking the eastern Upper Valdarno Basin, Italy. The routing of sand-rich sediment resulted from the fast, intense weathering of the feldspar-rich, carbonate-deprived sandstone bedrock underlying the fan catchments. Although capable of entraining large boulders, high water discharge sustained tractional reworking along the proximal facies belts, hindering mass flow. The medial facies belts have a channelized, braided planform and are dominated by processes hardly distinguishable from those characterizing fluvial environments. Along the distal facies belts, extensive overbank tracts are composed of terminal splays and crevasse lobes, the spatial arrangement of which controlled the evolution of through-going tributary channels connected to the axial basin drainage. This study focused on the sedimentary processes, stratal architecture and morphodynamics of the alluvial fans and considered the effect of bedrock inheritance on their development. The results underline how granulometry and mass flow dominance are not distinctive of alluvial fan sedimentation
per se
and indicate how the critical detection of piedmont, radial palaeomorphology is crucial in the identification of ancient alluvial fans.
Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men
Authors: Konings Joke , Kremers Romy , Bloemen Saartje , Schurgers Evelien , Selmeczi Anna , Kelchtermans Hilde , van Meel Rinaldo , Meex Steven , Kleinegris Marie-Claire , de Groot Philip , Urbanus Rolf , Ninivaggi Marisa , de Laat Bas , Huskens Dana , Roest Mark , Remijn Jasper 
Published: February 2016

SummaryPhysical exercise is recommended for a healthy lifestyle. Strenuous exercise, however, may trigger the haemostatic system, increasing the risk of vascular thrombotic events and the incidence of primary cardiac arrest. Our goal was to study the effects of strenuous exercise on risk factors of cardiovascular disease. Blood was collected from 92 healthy volunteers who participated in the amateur version of the protour Amstel Gold cycling race, before and directly after the race. Thrombin generation showed a shortening of the lag time and time to peak and an increase of the velocity index. Interestingly, the endogenous thrombin potential measured in plasma decreased due to reduced prothrombin conversion. Platelet reactivity increased and this effect was stronger in men than in women. Lower fibrinogen and higher D-dimer levels after exercise indicated higher fibrin formation. On the other hand, fibrinolysis was also elevated as indicated by a shortening of the clot lysis time. Exercise activated the endothelium (von Willebrand factor (VWF) and active VWF levels were elevated) and the immune system (concentrations IL-6, IL-8, MCP-1, RANTES and PDGF increased). Additionally, an increased cardiac troponin T level was measured post-exercise. Strenuous exercise induces a temporary hyperreactive state in the body with enhanced proand anticoagulant responses. As strenuous exercise has a more pronounced effect on platelet function in male subjects, this gives a possible explanation for the higher incidence of sudden cardiac death during exercise compared to women. This trial is registered at www.clinicaltrials.gov as NCT02048462.
Do Genetic Factors Modify the Relationship Between Obesity and Hypertriglyceridemia?
Authors: Ali Ashfaq , Varga Tibor V. , Stojkovic Ivana A. , Schulz Christina-Alexandra , Hallmans Göran , Barroso Inês , Poveda Alaitz , Renström Frida , Orho-Melander Marju , Franks Paul W. 
Published: February 2016

Background—
Obesity is a major risk factor for dyslipidemia, but this relationship is highly variable. Recently published data from 2 Danish cohorts suggest that genetic factors may underlie some of this variability.

Methods and Results—

We tested whether established triglyceride-associated loci modify the relationship of body mass index (BMI) and triglyceride concentrations in 2 Swedish cohorts (the Gene–Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk [GLACIER Study; N=4312] and the Malmö Diet and Cancer Study [N=5352]). The genetic loci were amalgamated into a weighted genetic risk score (WGRS
TG
) by summing the triglyceride-elevating alleles (weighted by their established marginal effects) for all loci. Both BMI and the WGRS
TG
were strongly associated with triglyceride concentrations in GLACIER, with each additional BMI unit (kg/m
2
) associated with 2.8% (
P
=8.4×10
–84
) higher triglyceride concentration and each additional WGRS
TG
unit with 2% (
P
=7.6×10
–48
) higher triglyceride concentration. Each unit of the WGRS
TG
was associated with 1.5% higher triglyceride concentrations in normal weight and 2.4% higher concentrations in overweight/obese participants (
P
interaction
=0.056). Meta-analyses of results from the Swedish cohorts yielded a statistically significant WGRS
TG
×BMI interaction effect (
P
interaction
=6.0×10
–4
), which was strengthened by including data from the Danish cohorts (
P
interaction
=6.5×10
–7
). In the meta-analysis of the Swedish cohorts, nominal evidence of a 3-way interaction (WGRS
TG
×BMI×sex) was observed (
P
interaction
=0.03), where the WGRS
TG
×BMI interaction was only statistically significant in females. Using protein–protein interaction network analyses, we identified molecular interactions and pathways elucidating the metabolic relationships between BMI and triglyceride-associated loci.

Conclusions—
Our findings provide evidence that body fatness accentuates the effects of genetic susceptibility variants in hypertriglyceridemia, effects that are most evident in females.
Circles of Confidence in Correspondence
Authors: van den Heuvel Charles , Weingart Scott B. , Spelt Nils , Nellen Henk 
Published: February 2016

Science in the early modern world depended on openness in scholarly communication. On the other hand, a web of commercial, political, and religious conflicts required broad measures of secrecy and confidentiality; similar measures were integral to scholarly rivalries and plagiarism. This paper analyzes confidentiality and secrecy in intellectual and technological knowledge exchange via letters and drawings. We argue that existing approaches to understanding knowledge exchange in early modern Europe – which focus on the Republic of Letters as a unified entity of corresponding scholars – can be improved upon by analyzing multilayered networks of communication. We describe a data model to analyze circles of confidence and cultures of secrecy in intellectual and technological knowledge exchanges. Finally, we discuss the outcomes of a first experiment focusing on the question of how personal and professional/official relationships interact with confidentiality and secrecy, based on a case study of the correspondence of Hugo Grotius.
Influence of the Quasi-Biennial Oscillation and Sea Surface Temperature Variability on Downward Wave Coupling in the Northern Hemisphere
Authors: Lubis Sandro W. , Matthes Katja , Omrani Nour-Eddine , Harnik Nili , Wahl Sebastian 
Published: February 2016

Abstract
Downward wave coupling occurs when an upward-propagating planetary wave from the troposphere decelerates the flow in the upper stratosphere and forms a downward reflecting surface that redirects waves back to the troposphere. To test this mechanism and potential factors influencing the downward wave coupling, three 145-yr sensitivity simulations with NCAR’s Community Earth System Model [CESM1(WACCM)], a state-of-the-art high-top chemistry–climate model, are analyzed. The results show that the quasi-biennial oscillation (QBO) and SST variability significantly impact downward wave coupling. Without the QBO, the occurrence of downward wave coupling is significantly suppressed. In contrast, stronger and more persistent downward wave coupling occurs when SST variability is excluded.
The above influence on the occurrence of downward wave coupling is mostly due to a direct influence of the QBO and SST variability on stratospheric planetary wave source and propagation. The strengths of the tropospheric circulation and surface responses to a given downward wave coupling event, however, behave differently. The surface anomaly is significantly weaker (stronger) in the experiment with fixed SSTs (without QBO), even though the statistical signal of downward wave coupling is strongest (weakest) in this experiment. This apparent mismatch is explained by the differences in the strength of the synoptic-scale eddy–mean flow feedback and the possible contribution of SST anomalies in the North Atlantic during the downward wave coupling event. The weaker synoptic-scale eddy–mean flow feedback and the absence of the positive NAO-related SST-tripole pattern in the fixed SST experiment are consistent with a weaker tropospheric response to downward wave coupling. The results highlight the importance of synoptic-scale eddies in setting the tropospheric response to downward wave coupling.
Exploring the Effects of Solar Radiation Management on Water Cycling in a Coupled Land–Atmosphere Model*
Authors: Dagon Katherine , Schrag Daniel P. 
Published: February 2016

Abstract
Solar radiation management (SRM) has been proposed as a form of geoengineering to reduce the climate effects of anthropogenic greenhouse gas emissions. Modeling studies have concluded that SRM, through a reduction in total solar irradiance by approximately 2%, roughly compensates for global mean temperature changes from a doubling of carbon dioxide concentrations. This paper examines the impact of SRM on the terrestrial hydrologic cycle using the Community Land Model, version 4, coupled to the Community Atmosphere Model, version 4, with reductions in solar radiation relative to simulations with present-day and elevated CO2 concentrations. There are significant global and regional impacts due to vegetation–climate interactions that are not compensated when reductions in total solar irradiance of 1%, 2%, and 3% are imposed on top of a doubling of present-day CO2 concentrations. Water cycling slows down under SRM, including decreases in global mean precipitation and evapotranspiration. Changes in runoff and soil moisture are spatially and temporally variable, with implications for local water availability. In the tropics, evapotranspiration decreases because of increases in vegetation water use efficiency. In northern midlatitudes, soil moisture increases when evapotranspiration decreases, with some exceptions during boreal summer. Changes in soil evaporation influence water cycling in the southern subtropics, rather than changes in transpiration. The hydrologic response to SRM is nonlinear, with global mean decreases greater than expected. These results imply that SRM may not compensate for higher greenhouse gas concentrations when one considers land–atmosphere interactions.
Dynamical Attribution of Recent Variability in Atlantic Overturning
Authors: Pillar Helen R. , Heimbach Patrick , Johnson Helen L. , Marshall David P. 
Published: February 2016

Abstract
Attributing observed variability of the Atlantic meridional overturning circulation (AMOC) to past changes in surface forcing is challenging but essential for detecting any influence of anthropogenic forcing and reducing uncertainty in future climate predictions. Here, quantitative estimates of separate contributions from wind and buoyancy forcing to AMOC variations at 25°N are obtained. These estimates are achieved by projecting observed atmospheric anomalies onto model-based dynamical patterns of AMOC sensitivity to surface wind, thermal, and freshwater forcing over the preceding 15 years. Local wind forcing is shown to dominate AMOC variability on short time scales, whereas subpolar heat fluxes dominate on decadal time scales. The reconstructed transport time series successfully reproduces most of the interannual variability observed by RAPID–MOCHA. However, the apparent decadal trend in the RAPID–MOCHA time series is not captured, requiring improved model representation of ocean adjustment to subpolar heat fluxes over at least the past two decades and highlighting the importance of sustained monitoring of the high-latitude North Atlantic.
Investigating Possible Reciprocal Relations Between Depressive and Problem Gambling Symptoms in Emerging Adults
Authors: Chinneck Annie , Mackinnon Sean P. , Stewart Sherry H. 
Published: February 2016

Objective: Previous cross-sectional research has shown that depression and problem gambling co-occur. Longitudinal research, however, allows for a better determination of directionality, as behavioural changes in gambling involvement can be more reliably studied over time. Our study assesses symptoms of depression and problem gambling across 4 waves and addresses whether their relation is directional (with one reliably preceding the other), bidirectional, or pathoplastic. Method: As part of the Manitoba Longitudinal Study of Young Adults, prospective data were collected on Canadian young adults’ (Wave 1: n = 679, 51.8% female, aged 18 to 20 years) depressive symptoms, involvement in gambling, and risky gambling behaviour. Recruitment and the first cycle of data collection (Wave 1) took place in fall 2007. Three additional waves of data collection then occurred in 12- to 18-month intervals: fall 2008, spring 2010, and spring 2011. The Problem Gambling Severity Index and the Composite International Diagnostic Interview—Short Form were administered through telephone interview at each wave. Results: Bivariate growth curves showed that depressive and problem gambling symptoms were positively correlated at Wave 1, Wave 2, and Wave 4. Neither disorder was found to be a risk factor for the other, and depression and problem gambling were not pathoplastically related (that is, increases in one did not result in increases in the other over time, and vice versa). Conclusions: While depression and problem gambling are related, their co-occurrence may be better explained not by depressive- or gambling-related risk, but by the presence of a common underlying factor (such as substance abuse).
Employer Best Practice Guidelines for the Return to Work of Workers on Mental Disorder–Related Disability Leave
Authors: Dewa Carolyn S. , Trojanowski Lucy , Joosen Margot C. W. , Bonato Sarah 
Published: February 2016

Objective: There has been an increasing number of employer best practice guidelines (BPGs) for the return to work (RTW) from mental disorder–related disability leave. This systematic review addresses 2 questions: 1) What is the quality of the development and recommendations of these BPGs? and 2) What are the areas of agreement and discrepancy among the identified guidelines related to the RTW from mental illness–related disability leave? Method: A systematic literature search was performed using publically available grey literature and best practice portals. It focused on the RTW of workers with medically certified disability leave related to mental disorders. The Appraisal of Guidelines for Research and Evaluation II (AGREE II) was used to assess the quality of the development and recommendations of these BPGs. Results: A total of 58 unique documents were identified for screening. After screening, 5 BPGs were appraised using AGREE II; 3 BPGs were included in the final set. There were no discrepancies among the 3, although they were from different countries. They all agreed there should be: 1) well-described organizational policies and procedures for the roles and responsibilities of all stakeholders, 2) a disability leave plan, and 3) work accommodations. In addition, one guideline suggested supervisor training and mental health literacy training for all staff. Conclusion: Although there were no discrepancies among the 3 BPGs, they emphasized different aspects of RTW and could be considered to be complementary. Together, they provide important guidance for those seeking to understand employer best practices for mental illness–related disability.
In vivo quantification of gentamicin released from an implant coating
Authors: Nast S , Fassbender M , Bormann N , Beck S , Montali A , Lucke M , Schmidmaier G , Wildemann B 
Published: February 2016

Drug-releasing implants are gaining increasing interest. The present study reports a detailed physicochemical analysis of a polymeric coating based on poly(D,L-lactide) and the incorporated gentamicin combined with an in vitro and in vivo study of the gentamicin release. Differential scanning calorimeter, Fourier transform infrared spectroscopy, gel permeation chromatography and high-performance liquid chromatography showed no effect of the gamma sterilisation on the coating components or an interaction of the polymer and the gentamicin. Microbiological analysis revealed an inhibition of bacterial growth on the implant surface. For the in vivo study, gentamicin-coated wires were implanted into the tibiae of rats and harvested at different time points up to day 42. To monitor the release in vivo, gentamicin was quantified in serum, bone, endosteum, kidney, and on the explanted wires. Gentamicin was detectable over a time period of 42 days in the endosteum, up to seven days in the kidney, up to 4 h in the bone and at the end of the experiment on one of eight wires. The locally released gentamicin caused no histological changes of the kidney. Microbiologically active concentrations of released gentamicin were found in the endosteum up to 4 h after implantation. The combination of different methods supports the individual results, where quantification is complemented by visualisation or antimicrobial activity. This work demonstrates that the coating procedure results in no substantial alteration of the incorporated drug and that the in vitro burst release occurs also in vivo.
Insomnia symptoms, perceived stress and coping strategies in patients with systemic lupus erythematosus
Authors: Palagini L , Mauri M , Faraguna U , Carli L , Tani C , Dell’Osso L , Mosca M , Riemann D 
Published: February 2016

Objective The aim of this study is to evaluate perceived stress and coping strategies in individuals with systemic lupus erythematosus (SLE) according to the presence of insomnia symptoms, using a set of variables that include anxiety and depressive symptoms evaluation. Methods Ninety SLE women were evaluated in a cross-sectional study using the Perceived Stress Scale (PSS), Brief COPE, Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Beck Depression Inventory (BDI) and Self-rating Anxiety Scale (SAS). Results Individuals with insomnia symptoms ( n = 57, 66%) presented higher PSS ( p < 0.001), PSQI ( p < 0.0001), BDI, ( p < 0.0001) scores and showed less-effective coping strategies such as the use of behavioral disengagement ( p = 0.04), self-blame ( p = 0.02) and emotional-focused coping ( p = 0.001). In a multi-regression model ISI was the independent determinant of high PSS and of behavioral disengagement; PSQI was the only determinant of self-blame ( p = 0.02) and emotional-focused coping. Conclusions SLE individuals with insomnia symptoms show high levels of perceived stress and more frequent use of disengaging and emotional-focused coping strategies. This body of evidence suggests that individuals with SLE and comorbid insomnia symptoms may therefore require additional interventions for insomnia.
Explaining the geographic spread of emerging epidemics: a framework for comparing viral phylogenies and environmental landscape data
Authors: Dellicour Simon , Rose Rebecca , Pybus Oliver G. 
Published: February 2016

AbstractBackgroundPhylogenetic analysis is now an important tool in the study of viral outbreaks. It can reconstruct epidemic history when surveillance epidemiology data are sparse, and can indicate transmission linkages among infections that may not otherwise be evident. However, a remaining challenge is to develop an analytical framework that can test hypotheses about the effect of environmental variables on pathogen spatial spread. Recent phylogeographic approaches can reconstruct the history of virus dispersal from sampled viral genomes and infer the locations of ancestral infections. Such methods provide a unique source of spatio-temporal information, and are exploited here.ResultsWe present and apply a new statistical framework that combines genomic and geographic data to test the impact of environmental variables on the mode and tempo of pathogen dispersal during emerging epidemics. First, the spatial history of an emerging pathogen is estimated using standard phylogeographic methods. The inferred dispersal path for each phylogenetic lineage is then assigned a “weight” using environmental data (e.g. altitude, land cover). Next, tests measure the association between each environmental variable and lineage movement. A randomisation procedure is used to assess statistical confidence and we validate this approach using simulated data. We apply our new framework to a set of gene sequences from an epidemic of rabies virus in North American raccoons. We test the impact of six different environmental variables on this epidemic and demonstrate that elevation is associated with a slower rabies spread in a natural population.ConclusionThis study shows that it is possible to integrate genomic and environmental data in order to test hypotheses concerning the mode and tempo of virus dispersal during emerging epidemics.