bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Learning Progression for Geometrical Measurement in One, Two, and Three Dimensions
Authors: Kim Eun Mi , Haberstroh Jeff , Peters Stephanie , Howell Heather , Nabors Oláh Leslie 
Published: November 2017

AbstractAs part of the CBAL® learning and assessment initiative in mathematics, we developed a hypothesized learning progression (LP) for geometrical measurement in 1, 2, and 3 dimensions based on a synthesis of empirical literature in this field and through expert review. The geometrical measurement LP is intended to represent a developmental progression of students' understandings and learning for 1‐, 2‐, and 3‐dimensional measurement in terms of transitions along levels within a dimension and connections across the 3 dimensions. In addition, we designed cognitive laboratory tasks associated with the levels of the geometrical measurement LP. The development process of the geometrical measurement LP and cognitive laboratory tasks presented here provide guidance for future development of LPs and task design that would provide the evidence supporting the proposed LPs.
Impaired Rivaroxaban Clearance in Mild Renal Insufficiency With Verapamil Coadministration: Potential Implications for Bleeding Risk and Dose Selection
Authors: Greenblatt David J. , Patel Maulik , Harmatz Jerold S. , Nicholson Wayne T. , Rubino Christopher M. , Chow Christina R. 
Published: November 2017

AbstractPharmacokinetics and antithrombotic effects of the Factor Xa inhibitor rivaroxaban were studied in subjects with mild renal insufficiency concurrently taking the P‐glycoprotein and moderate CYP3A inhibitor verapamil, a drug commonly administered to patients with hypertension, ischemic heart disease, or atrial fibrillation. Age‐matched controls with normal renal function were studied concurrently. Subjects’ overall mean age was 59 years. Mean creatinine clearance values in the 2 groups were 105 and 71 mL/min. After single 20‐mg oral doses, rivaroxaban area under the curve (AUC) was increased by a factor of 1.11 (ratio of geometric means [RGM]) in mild renal insufficiency compared to controls. Verapamil coadministration independently increased AUC to the same extent in both the mild renal insufficiency and control groups (RGM, 1.39 and 1.43). Concurrent mild renal insufficiency and verapamil produced additive inhibition compared to controls without verapamil (RGM, 1.58). Prothrombin time (PT) prolongation and Factor Xa inhibition tracked plasma rivaroxaban, and were enhanced by verapamil. Concentration–response relationships for PT (linear) and Factor Xa inhibition (hyperbolic) were unaffected by renal function or verapamil. The absolute and relative increases in rivaroxaban AUC caused by verapamil in mild renal insufficiency subjects are potentially associated with an increased bleeding risk. Modification of recommended dosage may be required in this combination of circumstances to reduce risk to patients.
Multifunctional in vivo imaging for monitoring wound healing using swept‐source polarization‐sensitive optical coherence tomography
Authors: Park Kwan S. , Choi Woo June , Song Shaozhen , Xu Jingjiang , Wang Ruikang K. 
Published: November 2017

Background and ObjectiveWound healing involves a complex and dynamic biological process in response to tissue injury. Monitoring of the cascade of cellular events is useful for wound management and treatment. The aim of this study is to demonstrate the potential of multifunctional polarization‐sensitive optical coherence tomography (PS‐OCT) to longitudinally monitor the self‐healing process in a murine cutaneous wound model.Materials and MethodsA multi‐functional PS‐OCT system based on swept source OCT configuration (1,310 nm central wavelength) was designed to obtain simultaneously microstructural, blood perfusion, and birefringent information of a biological tissue in vivo. A 1‐mm‐diameter wound was generated in a mouse pinna with a complete biopsy punch. Afterwards, the self‐healing process of the injured tissue was observed every week over 6‐week period using the multifunctional system to measure changes in the tissue birefringence. Further OCT angiography (OCTA) was used in post data processing to obtain blood perfusion information over the injured tissue.ResultsThree complementary images indicating the changes in anatomical, vascular, and birefringent information of tissue around wound were simultaneously provided from a 3‐dimensional (3‐D) PS‐OCT data set during the wound repair over 1 month. Specifically, inflammatory and proliferative phases of wound healing were characterized by thickened epidermal tissue (from OCT images) and angiogenesis (from OCT angiography images) around wound. Also, it was observed that the regenerating tissues had highly realigned birefringent structures (from PS‐OCT images).ConclusionThis preliminary study suggests that the proposed multi‐functional imaging modality has a great potential to improve the understanding of wound healing through non‐invasive, serial monitoring of vascular and tissue responses to injury. Lasers Surg. Med. 50:213–221, 2018. © 2017 Wiley Periodicals, Inc.
Observational Constraints on Cloud Feedbacks: The Role of Active Satellite Sensors
Authors: Winker David , Chepfer Helene , Noel Vincent , Cai Xia 
Published: November 2017

AbstractCloud profiling from active lidar and radar in the A-train satellite constellation has significantly advanced our understanding of clouds and their role in the climate system. Nevertheless, the response of clouds to a warming climate remains one of the largest uncertainties in predicting climate change and for the development of adaptions to change. Both observation of long-term changes and observational constraints on the processes responsible for those changes are necessary. We review recent progress in our understanding of the cloud feedback problem. Capabilities and advantages of active sensors for observing clouds are discussed, along with the importance of active sensors for deriving constraints on cloud feedbacks as an essential component of a global climate observing system.
The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway
Authors: Wang Ruihua , Huang Shengfeng , Fu Xianan , Huang Guangrui , Yan Xinyu , Yue Zirui , Chen Shangwu , Li Yingqiu , Xu Anlong 
Published: November 2017

AbstractIn vertebrates, PIAS genes encode versatile cellular regulators, with functions extremely complex and redundant. Here we try to understand their functions from an evolutionary perspective. we evaluate the sequences, expression and molecular functions of amphioxus PIAS genes and compare them with their vertebrate counterparts. Phylogenetic analysis suggests a single PIAS gene in ancestral chordates, which has been duplicated into four families (PIAS1-4) in vertebrates by 2R-WGD but remained single in a basal chordate (amphioxus). Amphioxus PIAS encodes two variants with and without a Serine/Threonine-rich tail, which are retained in human PIAS1-3 but lost in PIAS4. We show that amphioxus PIAS binds C-terminus of NF-κB Rel and blocks the DNA binding activity. In humans, such function is retained in PIAS1, altered in PIAS4, and lost in PIAS2-3. Instead, PIAS3 has evolved new ability to inhibit Rel by binding RHD and promoting SUMOylation. We show that amphioxus PIAS also inhibits NF-κB by binding with upstream signalling adaptor TICAM-like and MyD88. Finally, we verify that human PIAS1, 3 and 4, but not 2, were capable of these newly-discovered functions. Our study offers insight into the sub- and neo-functionalization of PIAS genes and suggests a conserved ancient role for chordate PIAS in NF-κB signalling.
Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells
Authors: Huang Deyu , Cui Luqing , Guo Pu , Xue Xijuan , Wu Qinghua , Hussain Hafiz Iftikhar , Wang Xu , Yuan Zonghui 
Published: November 2017

AbstractNivalenol (NIV), a type B trichothecenes commonly found in cereal crops, can cause growth impairment in animals. However, limited information about its mechanisms is available. Trichothecenes have been characterized as an inhibitor of protein synthesis and induce apoptosis in cells. Oxidative stress is considered an underlying mechanism. However, whether NIV can induce oxidative stress and apoptosis in rat pituitary cells line GH3 is unclear. The present study showed that NIV significantly reduced the viability of cells and caused oxidative stress in GH3 cells. Further experiments showed that nitric oxide (NO), but not ROS, mediated NIV-induced oxidative stress. Additionally, NIV induced caspase-dependent apoptosis, decrease in mitochondrial membrane potential and mitochondrial ultrastructural changes. However, NIV-induced caspase activation, mitochondrial damage and apoptosis were partially alleviated by Z-VAD-FMK or NO scavenger hemoglobin. Finally, NIV changed the expression of growth-associated genes and pro-inflammatory cytokines. NIV also reduced the GH secretion in GH3 cells, which was reversed by hemoglobin. Taken together, these results suggested that NIV induced apoptosis in caspase-dependent mitochondrial pathway in GH3 cells, which might be an underlying mechanism of NIV-induced GH deficiency. Importantly, NO played a critical role in the induction of oxidative stress, apoptosis and GH deficiency in NIV-treated GH3 cells.
The Influence of Target and Masker Characteristics on Infants' and Adults' Detection of Speech
Authors: Oster Monika-Maria , Werner Lynne A. 
Published: November 2017

Purpose
Several investigators have compared infants' detection of speech in speech and nonspeech maskers to evaluate developmental differences in masking. Such comparisons have produced contradictory results, possibly because each investigation used different stimuli. The current study examined target and masker effects on infants' and adults' detection of speech.

Method

An observer-based procedure was used to compare infants' and adults' detection of the vowel /ʌ/ and the word “baby” in a 2-talker speech masker and matched speech-spectrum noise. The measure of performance was
d′
. A total of 43 7-month-old infants and 41 young adults were randomly assigned to 1 target–masker combination condition, and mean performance was compared across conditions at each age.

Results
Adults' detection was influenced by an interaction between the target and the masker: Adults detected the vowel better in the 2-talker masker than in speech-spectrum noise but detected the word equally well in the 2 maskers. In contrast, infants detected both targets better in speech-spectrum noise than in the 2-talker masker.

Conclusions
The relative effects of the masker on target detection by infants and adults depend on the target to be detected. Thus, conclusions drawn about differences between infants and adults in the mechanisms responsible for masking will depend on the stimuli. Standardization of speech stimuli in developmental research would help clarify the nature of infants' segregation difficulties.

Supplemental Material

https://doi.org/10.23641/asha.5613139
A Rare Case of Triceps Brachii Injury after Electrocution
Authors: Lana Debora , Tarallo Luigi , Catani Fabio 
Published: November 2017

AbstractInjuries of the triceps brachii muscle are a rare entity and mostly concern its distal tendon. These represent the least common of all muscle and tendons injuries. The most common reported causes are repeated strong physical efforts, a fall on an outstretched forearm when a sudden deceleration is put on contract triceps, or a direct trauma. High-dosed and prolonged corticosteroid therapies, repeated local steroid injections, chronic renal failure, diabetes, rheumatoid arthritis, hyperparathyroidism, and osteogenesis imperfecta are reported as systemic causes. Even rarer are lesions of muscle fibers and avulsions or rupture at its musculotendinous junction, and these can be caused by direct trauma or by forced elbow flexion during triceps contraction. To the best of our knowledge, there is no article in the literature describing this type of injury that occurred after electrocution. In this article, we report an uncommon case of intramuscular tear associated with insertional distal tendon injury occurred in a man survived to high-voltage electric discharge.
Uterocervical Angle Measurement Improves Prediction of Preterm Birth in Twin Gestation
Authors: Tenbrink Emily , Onslow Mitchell , Patil Avinash , Knight Jordan 
Published: November 2017

Objective Twin pregnancies are associated with an increased risk of spontaneous preterm birth. Our objective was to compare the performance of uterocervical angle to cervical length as predictors of spontaneous preterm birth in this population.
Methods We conducted a retrospective cohort study of twin gestations at a single center from May 2008 to 2016 who received a transvaginal ultrasound for the evaluation of the cervix between 16 0/7 and 23 0/7 weeks. The primary outcome was prediction of preterm birth <28 and <32 weeks by uterocervical angle and cervical length.
Results Among 259 women with twin gestation, the mean gestational age at birth was 34.83 ± 3.48 weeks. Receiver operator characteristic curves demonstrated optimal prediction of spontaneous preterm birth prior to 32 weeks at a uterocervical angle >110° (80% sensitivity, 82% specificity) [odds ratio (OR), 15.7 (95% confidence interval (CI), 7.2–34.4)] versus cervical length <20 mm (53% sensitivity, 85% specificity; p < 0.001, OR, 6.4 [95% CI, 2.3–17.8]) and similarly, prior to 28 weeks at a uterocervical angle >114° (OR, 24.3 [95% CI, 6.7–88.5]) compared with cervical length <20 mm (OR, 11.4 [95% CI, 3.5–36.7]).
Conclusion Uterocervical angles >110° performed better than cervical length for the prediction of spontaneous preterm birth in twin gestations.
Cerebral Ischemia in Active Giant Cell Arteritis: Clinical and Diagnostic Aspects in 36 Patients
Authors: Pfadenhauer K. , Ertl M. , Hittinger M. , Berlis A. 
Published: November 2017

Abstract
Background: Cerebral ischemia (CI) is an uncommon, sometimes life-threatening complication of active giant cell arteritis (aGCA) due to affection of the precerebral arteries.
Aim of the Study: To analyze and describe clinical findings and results of multimodal vascular imaging of the craniocervical arteries.
Patients and Methods: Out of 317 aGCA patients, 36 (11%) presented with CI. All patients underwent vascular imaging including ultrasonography (US) of the temporal arteries (TA) and precerebral arteries, biopsies were taken in 27, CTA/MRA were performed in 21 and FDG-PET in 18 patients.
Results: In 72% of patients, CI was located in the posterior circulation and in14% of patients, it occurred after beginning of steroid therapy. TA were normal on clinical and US examination in 10 patients (with normal biopsies in 5) but PET demonstrated GCA of the precerebral arteries in 9 of them. Abnormalities of the precerebral arteries typical of GCA were demonstrated by US as halos in 67% (in 61% halos of the vertebral arteries), CTA/MRA in 43% and PET in 72% of patients. Concurrent etiologies for CI were evident in 19% of patients (including >50% ICA stenosis in 3 and atrial fibrillation in 4 patients).
Conclusions: Awareness for GCA as a cause of CI requiring specific diagnostic and therapeutic steps is important. US, CTA, MRA and PET are valuable diagnostic tools for rapid detection of GCA involving the precerebral arteries in different stages of the disease even if the TA look normal.
Mengenentwicklung stationärer Behandlungen bei Erkrankungen der Wirbelsäule – Analyse der deutschlandweiten Krankenhausabrechnungsdaten von 2005 bis 2014
Authors: Nimptsch Ulrike , Bolczek Claire , Spoden Melissa , Schuler Ekkehard , Zacher Josef , Mansky Thomas 
Published: November 2017

Zusammenfassung
Hintergrund Seit der Einführung der Diagnosis related Groups (DRG) zur Vergütung akutstationärer Krankenhausleistungen wurden Anstiege der stationären Fallzahlen zur Behandlung von Erkrankungen der Wirbelsäule beobachtet. Ziel dieser Arbeit ist, diese Mengenentwicklung bevölkerungsbezogen und nach Behandlungsarten differenziert darzustellen.
Material und Methode In den deutschlandweiten Krankenhausabrechnungsdaten (DRG-Statistik) wurden Behandlungsfälle mit operativer sowie nicht operativer Versorgung von Wirbelsäulenerkrankungen identifiziert. Unter Berücksichtigung der demografischen Entwicklung wurde analysiert, in welchem Umfang sich die Fallzahlen im Zeitraum von 2005 bis 2014 verändert haben und in welchen Altersgruppen und bei welchen Eingriffs- bzw. Behandlungsarten Anstiege zu verzeichnen sind.
Ergebnisse Im Jahr 2014 (2005) wurden 289 000 (177 000) operativ versorgte und 463 000 (287 000) nicht operativ versorgte Behandlungsfälle identifiziert. Nach Bereinigung um demografische Faktoren wurden sowohl bei operativen als auch bei nicht operativen Behandlungen relative Fallzahlanstiege um jeweils ca. 50% beobachtet, die in höheren Altersgruppen und bei Frauen besonders ausgeprägt waren. Die Mengenentwicklung fiel je nach Art des Eingriffs bzw. der Behandlung sehr unterschiedlich aus. Bei den operativ versorgten Behandlungsfällen hat sich die Anzahl der Bandscheibenoperationen demografiebereinigt nur um + 5% erhöht während sich Wirbelkörperversteifungs- und -ersatzeingriffe, Kypho- und Vertebroplastien und alleinige Dekompressionen der Wirbelsäule mehr als verdoppelt haben. Bei den nicht operativ versorgten Behandlungsfällen wurde bei Behandlungen mit lokaler Schmerztherapie der Wirbelsäule ein demografiebereinigter Anstieg von + 142% beobachtet. Bei rein konservativen Behandlungen lag der demografiebereinigte Anstieg bei + 22%.
Schlussfolgerung Welche Ursachen den nicht demografiebedingten Fallzahlanstiegen zugrunde liegen, kann diese Untersuchung nicht direkt klären. Die stratifizierte Betrachtung der Fallzahlen in den verschiedenen Untergruppen kann aber dazu beitragen, die Entwicklungen differenziert einzuordnen und damit die Diskussion um eine mögliche Über- oder Fehlversorgung zielgerichteter als bisher zu führen.
Aufbau einer Präventionsberichterstattung in Bayern – Konzept und erste Umsetzungsschritte
Authors: Reisig Veronika , Kuhn Joseph , Poppe Franziska , Caselmann Wolfgang 
Published: November 2017

Zusammenfassung
Hintergrund Zur Weiterentwicklung der Prävention und Gesundheitsförderung im Rahmen der Umsetzung des Bayerischen Präventionsplans und des Gesetzes zur Stärkung der Gesundheitsförderung und Prävention (Präventionsgesetz) soll in Bayern eine systematische Präventionsberichterstattung aufgebaut werden.
Zielsetzung Das Konzept zur Präventionsberichterstattung in Bayern sieht vor, präventionsrelevante Daten aus der allgemeinen Gesundheitsberichterstattung mit Blick auf die Handlungsfelder des Bayerischen Präventionsplans um weitere Indikatoren zu ergänzen. Dabei geht es v. a. um Ergänzungen bei präventionsrelevanten Gesundheitsdeterminanten, den Präventionsaktivitäten und Präventionsausgaben sowie um eine Abbildung der Handlungsfelder und Zielsetzungen des Bayerischen Präventionsplans. Durch eine periodische Berichterstattung sollen Trends erkenntlich und ein Monitoring ermöglicht werden. Das Berichtswesen soll modular aufgebaut werden mit kürzeren, eher der Öffentlichkeitsarbeit dienenden Materialien und umfangreicheren Fachberichten. Nach Möglichkeit sollen auch regionale Daten für die Gesundheitsregionenplus bzw. die Gesundheitsämter bereitgestellt werden.
Umsetzung und erste Ergebnisse Eine umfassende Erhebung zur Präventionslandschaft in Bayern 2014/2015 sowie eine Befragung der Partner des Bayerischen Bündnisses für Prävention 2016 liefern Übersichtsdaten zum Präventionsgeschehen in Bayern. 2016 wurde ein Kernindikatorenset für die Begleitung der Umsetzung des Bayerischen Präventionsplans fertiggestellt und ein Datenfaltblatt zur Prävention veröffentlicht. Ein Tabellenband und ein Präventionsbericht sind für 2017 bzw. 2018 geplant.
Schlussfolgerung Die Präventionsberichterstattung, wie sie in Bayern konzipiert wurde, stellt wie die allgemeine Gesundheitsberichterstattung Übersichtsdaten bereit und ermöglicht auf dieser Basis ein Monitoring der Prävention. Für spezifischere Steuerungs- oder Evaluationsaufgaben sind vertiefende Verfahren notwendig. Herausforderungen bestehen u. a. in der (Weiter)Entwicklung valider, präventionsspezifischer Indikatoren, der Generierung einer prozessbegleitenden empirischen Datenbasis und nach Möglichkeit einer länderübergreifenden Abstimmung.
Preparation, in vitro Characterization and Pharmacokinetic Study of Coenzyme Q10 Long-Circulating Liposomes
Authors: Yang Shuoye 
Published: November 2017

AbstractLong-circulating liposomal delivery systems of encapsulated Coenzyme Q10 (CoQ10), a ubiquinone anti-cataract agent, were developed with different molar ratios of PEGylated lipids and/or cholesterol. The resulting samples were contrasted through observation of morphology, analysis of particle size and Zeta potential, and in vivo pharmacokinetics. A protamine aggregation method with high selectivity was developed to determine the encapsulation efficiency (EE), after which the liposome formulation was further optimized by applying a Box Behnken design (BBD) using EE as the evaluation index. The results showed that liposomes had a large, unilamellar structure, and that particle sizes of cholesterol-containing liposomes increased along with the increase of cholesterol molar percentage, while the size of PEGylated vesicles decreased slightly as PEG-lipid contents increasing. The optimum formulation and optimal values of each influencing factor were quantitatively obtained, and the measured value was highly consistent with the predicted results. In vivo evaluation performed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) demonstrated that liposomal encapsulation largely prolonged half-lives and improved bioavailability for vectors prepared with either lipid component, and the liposomes composed of both cholesterol and PEG-lipid possessed the best pharmacokinetic properties. The results suggest that incorporating high contents of cholesterol and PEG modification could be a potentially useful method for enhancing the length of circulation and the sustained release effect for liposome-encapsulated chemicals.
Morcellation equipment: past, present, and future
Authors: Miller Charles E. 
Published: November 2017

Purpose of review
This review was written in an effort to describe the evolution of power morcellation equipment from their creation to their current state. In addition, this review addresses the continuously evolving equipment involved with power morcellation and looks to describe where the field is headed in the future. In addition, recent professional and federal recommendations have changed the way power morcellation is being approached and has led to the development of contained morcellation systems, which, although in their infancy, are also being proven to be well tolerated options.

Recent findings
This article will review the most current research on electronic power morcellation and the multiple attempts to prove superiority from the many different types of equipment, and also the many different approaches to morcellation. In addition, with the adaptation to contained morcellation, this review will cover research focused on optimizing a containment system and the techniques involved.

Summary
In summary, this review is aimed at describing many of the currently available power morcellation products and contained morcellation systems in an effort to allow physicians to understand the different options available, and to discuss well tolerated, effective, and clinically proven techniques that can lead to improved surgical outcomes in the future.