bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial Differences in the Incidence of Cardiovascular Risk Factors in Older Black and White Adults
Authors: Howard George , Safford Monika M. , Moy Claudia S. , Howard Virginia J. , Kleindorfer Dawn O. , Unverzagt Fredrick W. , Soliman Elsayed Z. , Flaherty Matthew L. , McClure Leslie A. , Lackland Daniel T. , Wadley Virginia G. , Pulley LeaVonne , Cushman Mary 
Published: September 2016

ObjectivesTo describe the incidence of cardiovascular risk factors, or race‐related disparities in incidence, across the age spectrum in adults.DesignLongitudinal cohort.SettingNational sample.ParticipantsCommunity‐dwelling black and white adults recruited between 2003 and 2007.MeasurementsIncident hypertension, diabetes mellitus, dyslipidemia and atrial fibrillation over 10 years of follow‐up in 10,801 adults, stratified according to age (45–54, 55–64, 65–74, ≥75).ResultsThere was no evidence (P ≥ .68) of an age‐related difference in the incidence of hypertension for white men (average incidence 38%), black men (48%), or black women (54%), although for white women incidence increased with age (45–54, 27%; ≥75, 40%). Incidence of diabetes mellitus was lower at older ages for white men (45–54, 15%; ≥75, 8%), black men (45–54, 29%; ≥75, 13%), and white women (45–54, 11%; ≥75, 4%), although there was no evidence (P = .11) of age‐related changes for black women (average incidence 21%). For dyslipidemia, incidence for all race–sex groups was approximately 20% for aged 45 to 54 but approximately 30% for aged 54 to 64 and 65 to 74 and approximately 22% for aged 75 and older. Incidence of atrial fibrillation was low at age 45 to 54 (<5%) but for aged 75 and older was approximately 20% for whites and 11% for blacks. The incidence of hypertension, diabetes mellitus, and dyslipidemia was higher in blacks across the age spectrum but lower for atrial fibrillation.ConclusionIncidence of risk factors remains high in older adults. Blacks have a higher incidence of hypertension, diabetes mellitus, and dyslipidemia after age 45, underscoring the ongoing importance of prevention of all three conditions in mid‐ to later life.
Trends in Austrian Resource Efficiency: An Exergy and Useful Work Analysis in Comparison to Material Use, CO2 Emissions, and Land Use
Authors: Eisenmenger Nina , Warr Benjamin , Magerl Andreas 
Published: September 2016

SummaryIn the past few years, resource use and resource efficiency have been implemented in the European Union (EU) environmental policy programs as well as international sustainable development programs. In their programs, the EU focuses on four resource types that should be addressed: materials, energy (or carbon dioxide [CO2] emissions), water, and land. In this article, we first discuss different perspectives on energy use and present the results of a long‐term exergy and useful work analysis of the Austrian economy for the period 1900–2012, using the methodology developed by Ayres and Warr. Second, we discuss Austrian resource efficiency by comparing the presented exergy and useful work data with material use, CO2 emissions, and land‐use data taken from statistical sources. This comparison provides, for the first time, a long‐term analysis of Austrian resource efficiency based on a broad understanding thereof and evaluates Austrian development in relation to EU and Austrian policy targets.
Life Cycle Impacts and Benefits of Wood along the Value Chain: The Case of Switzerland
Authors: Suter Florian , Steubing Bernhard , Hellweg Stefanie 
Published: September 2016

SummarySustainable use of wood may contribute to coping with energy and material resource challenges. The goal of this study is to increase knowledge of the environmental effects of wood use by analyzing the complete value chain of all wooden goods produced or consumed in Switzerland. We start from a material flow analysis of current wood use in Switzerland. Environmental impacts related to the material flows are evaluated using life cycle assessment–based environmental indicators. Regarding climate change, we find an overall average benefit of 0.5 tonnes carbon dioxide equivalent per cubic meter of wood used. High environmental benefits are often achieved when replacing conventional heat production and energy‐consuming materials in construction and furniture. The environmental performance of wood is, however, highly dependent on its use and environmental indicators. To exploit the mitigation potential of wood, we recommend to (1) apply its use where there are high substitution benefits like the replacement of fossil fuels for energy or energy‐intensive building materials, (2) take appropriate measures to minimize negative effects like particulate matter emissions, and (3) keep a systems perspective to weigh effects like substitution and cascading against each other in a comprehensive manner. The results can provide guidance for further in‐depth studies and prospective analyses of wood‐use scenarios.
Material Flow Accounts and Driving Factors of Economic Growth in the Philippines
Authors: Martinico‐Perez Marianne Faith G. , Fishman Tomer , Okuoka Keijiro , Tanikawa Hiroki 
Published: September 2016

SummaryThis study looks into material flow trends in the Philippines from 1985 to 2010 by utilizing the methodology of economy‐wide material flow analysis. Using domestic data sources, this study presents disaggregated annual material flow trends in terms of four major material categories, namely: biomass; fossil energy carriers; ores and industrial minerals; and construction minerals. The results describe in detail the growth of material flows in a high‐density country at the onset of its development and reveal the shift of material consumption from dominance of renewable materials in 1985 to nonrenewable materials in 2010. IPAT analysis shows that the increase in material consumption was driven by population growth from 1985 to 1998 and by growth in affluence from 1999 to 2010. However, high inequalities amidst the growing economy suggest that a small group of wealthy people have influenced the acceleration of material consumption in the Philippines. The results of this research are intended to provide a thorough analysis of the processes occurring in Philippine economic growth in order to assist in tackling implications for the important issue of sustainable resource management.
Palaeobiology of Hyaenodon exiguus (Hyaenodonta, Mammalia) based on morphometric analysis of the bony labyrinth
Authors: Pfaff Cathrin , Nagel Doris , Gunnell Gregg , Weber Gerhard W. , Kriwet Jürgen , Morlo Michael , Bastl Katharina 
Published: September 2016

AbstractSpecies of the extinct genus Hyaenodon were among the largest carnivorous mammals from the Late Eocene through Early Miocene in North America, Europe and Asia. The origin, phylogeny and palaeobiology of Hyaenodonta are still ambiguous. Most previous studies focused on teeth and dental function in these highly adapted species, which might be influenced by convergent morphologies. The anatomy of the bony labyrinth in vertebrates is generally quite conservative and, additionally, was used in functional–morphological studies. This study provides the first anatomical description of the bony labyrinth of the extinct European species Hyaenodon exiguus in comparison to selected extant carnivoran taxa discussed from a functional–morphological perspective. Hyaenodon exiguus may have occupied a hyaena‐like dietary niche with a semi‐arboreal lifestyle, based on the relative height, width and length of the semicircular canals of the inner ear. However, this contradicts previous functional–morphological studies focusing on the diameter of the canals, which presumably represent the signal of locomotion mode.
Evaluation of the safety in dogs of long‐term, daily oral administration of capromorelin, a novel drug for stimulation of appetite
Authors: Zollers B. , Huebner M. , Armintrout G. , Rausch‐Derra L. C. , Rhodes L. 
Published: September 2016

The objective of the study was to evaluate the safety of capromorelin, a ghrelin agonist that stimulates appetite and causes increased body weight and the release of growth hormone (GH). Beagle dogs (n = 32) received either oral placebo or 0.3, 7, or 40 mg/kg capromorelin once daily for 12 consecutive months. Safety was evaluated by physical examinations, including ECG and ophthalmic examinations, and comprehensive clinical pathology. Serum levels of capromorelin, GH, and insulin‐like growth factor 1 (IGF‐1) were measured periodically. Necropsies and histopathological evaluations were performed at study termination. As expected, GH and IGF‐1 levels were mildly increased in capromorelin‐treated dogs. Adverse events were limited to mild emesis and loose stools in all groups and excess salivation among some dogs receiving higher capromorelin doses. Clinical pathology testing was generally normal, although blood lipids and alkaline phosphatase levels were moderately increased among dogs receiving capromorelin. Treated dogs had slightly longer post‐treatment PR intervals seen on ECG, but with no changes in cardiac histopathology. Postmortem findings were normal. Drug‐related increases in liver weight were linked to overall increases in body weight. Capromorelin was well tolerated in dogs at daily doses up to 40 mg/kg for 12 months, demonstrating a wide safety margin.
Impact of Mycotoxins on Aquaculture Fish Species: A Review
Authors: Matejova Iveta , Svobodova Zdenka , Vakula Josef , Mares Jan , Modra Helena 
Published: September 2016

AbstractAs the use of ingredients of plant origin has increased in aquaculture, the potential for mycotoxin poisoning in fish has increased accordingly. Feeding fish with mycotoxin‐contaminated feed can lead to a breakdown in health, manifested as tissue damage or through immunosuppression. Both effects can lead to an increase in mortality. To date, however, there have been few reports of mycotoxins in feed at toxic concentrations. The aim of this study was to describe the effects of those toxic mycotoxins most commonly found as contaminants in fish feed. In terms of fish health, the most harmful mycotoxins are aflatoxin B1 and Fusarium mycotoxins. The most sensitive fish species was rainbow trout, Oncorhynchus mykiss. Future research in the field of mycotoxicosis in fish should be focused on the effects of combinations of mycotoxins.
Temporal dynamics and persistence of sponge assemblages in a Central Pacific atoll lagoon
Authors: Knapp Ingrid S.S , Williams Gareth J. , Bell James J. 
Published: September 2016

AbstractSponges are important components of coral reef fauna, although little is known of their temporal dynamics. Sponges dominate the lagoon system at Palmyra Atoll in the Central Pacific, which may not be its natural state. Here we examined the temporal variability and recruitment rates of these sponge assemblages to determine if they are stable and examined the evidence that a recent transition has occurred from a coral‐ to sponge‐dominated system. We found 24 sponge species in permanent quadrats in the lagoon between 2009 and 2011, and 11 species on our recruitment panels. The sponge assemblage composition and abundance did not vary significantly between years and appear stable. Many sponge recruits were found in both years that the panels were examined although higher rates were recorded in the second year of the study. While it seems very possible that a change to a sponge‐dominated lagoon is associated with declining environmental quality at Palmyra as a result of modifications over 70 years ago, without pre‐modification data on reef assemblage composition this remains speculative. Our observations of short‐term temporal stability in the sponge assemblages at Palmyra highlight the potential for sponge‐dominated reef states to be maintained in degraded reef environments that are seemingly unsuitable for coral survival.
Shock‐induced thermal history of an EH3 chondrite, Asuka 10164
Authors: Kimura M. , Yamaguchi A. , Miyahara M. 
Published: September 2016

AbstractShock‐induced features are abundantly observed in meteorites. Especially, shock veins, including high‐pressure minerals, characterize many kinds of heavily shocked meteorite. On the other hand, no high‐pressure phases have been yet reported from enstatite chondrites. We studied a heavily shocked EH3 chondrite, Asuka 10164, containing a vein, which comprises fragments of fine‐grained silicate and opaque minerals, and chondrules. In this vein, we found a silica polymorph, coesite. This is the first discovery of a high‐pressure phase in enstatite chondrites. Other high‐pressure polymorphs were not observed in the vein. The assemblages and chemical compositions of minerals, and the occurrence of coesite indicate that the vein was subjected to the high‐pressure and temperature condition at about 3–10 GPa and 1000 °C. The host also experienced heating for a short time under lower temperature conditions, from ~700 to ~1000 °C, based on the opaque minerals typical of EH chondrites and textural features. Although the pressure condition of the vein in this chondrite is much lower than those in the other meteorites, our results suggest that all major meteorite groups contain high‐pressure polymorphs. Heavy shock events commonly took place in the solar system.
Diet‐related gut bacterial dysbiosis correlates with impaired development, increased mortality and Nosema disease in the honeybee (Apis mellifera)
Authors: Maes Patrick W. , Rodrigues Pedro A. P. , Oliver Randy , Mott Brendon M. , Anderson Kirk E. 
Published: September 2016

AbstractDysbiosis, defined as unhealthy shifts in bacterial community composition, can lower the colonization resistance of the gut to intrinsic pathogens. Here, we determined the effect of diet age and type on the health and bacterial community composition of the honeybee (Apis mellifera). We fed newly emerged bees fresh or aged diets, and then recorded host development and bacterial community composition from four distinct regions of the hosts’ digestive tract. Feeding fresh pollen or fresh substitute, we found no difference in host mortality, diet consumption, development or microbial community composition. In contrast, bees fed aged diets suffered impaired development, increased mortality and developed a significantly dysbiotic microbiome. The consumption of aged diets resulted in a significant reduction in the core ileum bacterium Snodgrassella alvi and a corresponding increase in intrinsic pathogen Frischella perrara. Moreover, the relative abundance of S. alvi in the ileum was positively correlated with host survival and development. The inverse was true for both F. perrara and Parasacharibacter apium. Collectively, our findings suggest that the early establishment of S. alvi is associated with healthy nurse development and potentially excludes F. perrara and P. apium from the ileum. Although at low abundance, establishment of the common midgut pathogen Nosema spp. was significantly associated with ileum dysbiosis and associated host deficiencies. Moreover, dysbiosis in the ileum was reflected in the rectum, mouthparts and hypopharyngeal glands, suggesting a systemic host effect. Our findings demonstrate that typically occurring alterations in diet quality play a significant role in colony health and the establishment of a dysbiotic gut microbiome.
How the truffle got its mate: insights from genetic structure in spontaneous and planted Mediterranean populations of Tuber melanosporum
Authors: Taschen E. , Rousset F. , Sauve M. , Benoit L. , Dubois M.‐P. , Richard F. , Selosse M.‐A. 
Published: September 2016

AbstractThe life cycles and dispersal of edible fungi are still poorly known, thus limiting our understanding of their evolution and domestication. The prized Tuber melanosporum produces fruitbodies (fleshy organs where meiospores mature) gathered in natural, spontaneously inoculated forests or harvested in plantations of nursery‐inoculated trees. Yet, how fruitbodies are formed remains unclear, thus limiting yields, and how current domestication attempts affect population genetic structure is overlooked. Fruitbodies result from mating between two haploid individuals: the maternal parent forms the flesh and the meiospores, while the paternal parent only contributes to the meiospores. We analyzed the genetic diversity of T. melanosporum comparatively in spontaneous forests vs. plantations, using SSR polymorphism of 950 samples from South‐East France. All populations displayed strong genetic isolation by distance at the metric scale, possibly due to animal dispersal, meiospore persistence in soil, and/or exclusion of unrelated individuals by vegetative incompatibility. High inbreeding was consistently found, suggesting that parents often develop from meiospores produced by the same fruitbody. Unlike maternal genotypes, paternal mycelia contributed to few fruitbodies each, did not persist over years, and were undetectable on tree mycorrhizae. Thus, we postulate that germlings from the soil spore bank act as paternal partners. Paternal genetic diversity and outbreeding were higher in plantations than in spontaneous truffle‐grounds, perhaps because truffle growers disperse fruitbodies to maintain inoculation in plantations. However, planted and spontaneous populations were not genetically isolated, so that T. melanosporum illustrates an early step of domestication where genetic structure remains little affected.
ClpAP is an auxiliary protease for DnaA degradation in Caulobacter crescentus
Authors: Liu Jing , Francis Laura I. , Jonas Kristina , Laub Michael T. , Chien Peter 
Published: September 2016

SummaryThe Clp family of proteases is responsible for controlling both stress responses and normal growth. In Caulobacter crescentus, the ClpXP protease is essential and drives cell cycle progression through adaptor‐mediated degradation. By contrast, the physiological role for the ClpAP protease is less well understood with only minor growth defects previously reported for ΔclpA cells. Here, we show that ClpAP plays an important role in controlling chromosome content and cell fitness during extended growth. Cells lacking ClpA accumulate aberrant numbers of chromosomes upon prolonged growth suggesting a defect in replication control. Levels of the replication initiator DnaA are elevated in ΔclpA cells and degradation of DnaA is more rapid in cells lacking the ClpA inhibitor ClpS. Consistent with this observation, ClpAP degrades DnaA in vitro while ClpS inhibits this degradation. In cells lacking Lon, the protease previously shown to degrade DnaA in Caulobacter, ClpA overexpression rescues defects in fitness and restores degradation of DnaA. Finally, we show that cells lacking ClpA are particularly sensitive to inappropriate increases in DnaA activity. Our work demonstrates an unexpected effect of ClpAP in directly regulating replication through degradation of DnaA and expands the functional role of ClpAP in Caulobacter.
UV‐Induced DNA Damage and Mutagenesis in Chromatin
Authors: Mao Peng , Wyrick John J. , Roberts Steven A. , Smerdon Michael J. 
Published: September 2016

AbstractUV radiation induces photolesions that distort the DNA double helix and, if not repaired, can cause severe biological consequences, including mutagenesis or cell death. In eukaryotes, both the formation and repair of UV damage occur in the context of chromatin, in which genomic DNA is packaged with histones into nucleosomes and higher order chromatin structures. Here, we review how chromatin impacts the formation of UV photoproducts in eukaryotic cells. We describe the initial discovery that nucleosomes and other DNA binding proteins induce characteristic “photofootprints” during the formation of UV photoproducts. We also describe recent progress in genomewide methods for mapping UV damage, which echoes early biochemical studies, and highlights the role of nucleosomes and transcription factors in UV damage formation and repair at unprecedented resolution. Finally, we discuss our current understanding of how the distribution and repair of UV‐induced DNA damage influence mutagenesis in human skin cancers.
Breed differences of bull frozen‐thawed semen
Authors: Ntemka A , Tsousis G , Brozos C , Kiossis E , Boscos CM , Tsakmakidis IA 
Published: September 2016

ContentsThe objective of this study was to investigate the quality of frozen‐thawed semen from different bull breeds. Commercial frozen‐thawed bull semen samples (26 per breed, 130 totally) of five breeds (Holstein [Η], Brown Swiss [BS], Limousin [L], Belgian Blue [BB], Blonde d' Aquitaine [BA]) were used. After thawing, each semen sample was subjected to thermal resistance test (TR) for 0.5 and 1 hr at 38°C and hypo‐osmotic swelling test (HOST) for 1 hr at 150 mOsm at 37°C. Additionally, all samples were evaluated at times 0 hr (thawing), 0.5 hr (TR), 1 hr (TR) for kinetics by CASA [progressive, immotile, rapid, medium, slow moving spermatozoa, curvilinear velocity (VCL), average path velocity (VAP), straight line velocity (VSL), linearity (LIN), straightness (STR), beat cross‐frequency (BCF), amplitude of lateral head displacement (ALH), wobble (WOB)]. Moreover, directly after thawing, all semen samples were evaluated for morphometry, morphology, viability and DNA fragmentation. Statistical analysis was conducted using a mixed model for repeated measures. The results showed (a) higher VCL after thawing in H, L breeds compared to BB and BA, (b) higher VAP after thawing in L compared to BB, BA, (c) higher values of progressive spermatozoa after TR in H, BS compared to BB, BA, (d) higher values of rapid spermatozoa after thawing and 0.5 hr of TR in H, BS, L compared to BB, BA, (e) lower viability in BA after thawing compared to H, BS, BB, (f) lower morphological abnormalities in H compared to L, BB, (g) higher head length in Η compared to BB. No significant differences were observed in the results from HOST and DNA fragmentation between breeds. In conclusion, quality characteristics of frozen‐thawed bull semen are dependent on the breed. Frozen semen from BB and BA breeds should be handled more carefully after thawing, as it is more sensitive to stress.
Family Economy, Rural School Choice, and Flexischooling Children with Disabilities
Authors: Schafer Mark J. , Khan Shana S. 
Published: September 2016

AbstractMost homeschooled students would be more accurately described as “flexischooled,” partly homeschooled and partly enrolled in school. The popularity of these two alternatives to public or private school enrollment has increased over the past several decades to the extent that, by 2012 over 2 million students, 4 percent of the population, were either flexischooled or homeschooled in the United States. To understand why parents have pursued these options over enrollment, we employed a family economy perspective, arguing that family, child, and locational considerations shaped parents' motivations for homeschooling or flexischooling over enrollment. For example, parents' decisions were partially shaped by the interaction between children's disability status and rural location. Using data from the National Household Education Survey 2012, this article first describes the prevalence of flexischooling and full‐time homeschooling. Then, it demonstrates how various family, child, and locational factors shape the odds of flexischooling and homeschooling, and then examines the interaction between location and children's disability status in detail. We discuss the implications of our findings for family economy theoretical perspectives, flexischooling, and rural education research.