bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability based design of fluid power pitch systems for wind turbines
Authors: Liniger Jesper , Soltani Mohsen , Pedersen Henrik C. , Carroll James , Sepehri Nariman 
Published: February 2017

AbstractThis paper presents a qualitative design tool for evaluation of the risk for fluid power pitch systems. The design tool is developed with special attention to industry standard failure analysis methods and is aimed at the early phase of system design. Firstly, the concept of Fault Tree Analysis is used for systematic description of fault propagation linking failure modes to system effects. The methodology is conducted solely on a circuit diagram and functional behavior. The Failure Mode and Effects Criticality Analysis is subsequently employed to determine the failure mode risk via the Risk Priority Number. The Failure Mode and Effect Criticality Analysis is based on past research concerning failure analysis of wind turbine drive trains. Guidelines are given to select the severity, occurrence and detection score that make up the risk priority number. The usability of the method is shown in a case study of a fluid power pitch system applied to wind turbines. The results show a good agreement to recent field failure data for offshore turbines where the dominating failure modes are related to valves, accumulators and leakage. The results are further used for making design improvements to lower the overall risk of the pitch system. Copyright © 2017 John Wiley & Sons, Ltd.
Computational models of Bitemporal, Bifrontal and Right Unilateral ECT predict differential stimulation of brain regions associated with efficacy and cognitive side effects
Authors: Bai S. , Gálvez V. , Dokos S. , Martin D. , Bikson M. , Loo C. 
Published: February 2017

AbstractBackgroundExtensive clinical research has shown that the efficacy and cognitive outcomes of electroconvulsive therapy (ECT) are determined, in part, by the type of electrode placement used. Bitemporal ECT (BT, stimulating electrodes placed bilaterally in the frontotemporal region) is the form of ECT with relatively potent clinical and cognitive side effects. However, the reasons for this are poorly understood.ObjectiveThis study used computational modelling to examine regional differences in brain excitation between BT, Bifrontal (BF) and Right Unilateral (RUL) ECT, currently the most clinically-used ECT placements. Specifically, by comparing similarities and differences in current distribution patterns between BT ECT and the other two placements, the study aimed to create an explanatory model of critical brain sites that mediate antidepressant efficacy and sites associated with cognitive, particularly memory, adverse effects.MethodsHigh resolution finite element human head models were generated from MRI scans of three subjects. The models were used to compare differences in activation between the three ECT placements, using subtraction maps.Results and conclusionIn this exploratory study on three realistic head models, Bitemporal ECT resulted in greater direct stimulation of deep midline structures and also left temporal and inferior frontal regions. Interpreted in light of existing knowledge on depressive pathophysiology and cognitive neuroanatomy, it is suggested that the former sites are related to efficacy and the latter to cognitive deficits. We hereby propose an approach using binarised subtraction models that can be used to optimise, and even individualise, ECT therapies.
GSA: Genome Sequence Archive
Authors: Wang Yanqing , Song Fuhai , Zhu Junwei , Zhang Sisi , Yang Yadong , Chen Tingting , Tang Bixia , Dong Lili , Ding Nan , Zhang Qian , Bai Zhouxian , Dong Xunong , Chen Huanxin , Sun Mingyuan , Zhai Shuang , Sun Yubin , Yu Lei , Lan Li , Xiao Jingfa , Fang Xiangdong , Lei Hongxing , Zhang Zhang , Zhao Wenming 
Published: February 2017

Abstract
With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive (GSA; http://bigd.big.ac.cn/gsa or http://gsa.big.ac.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration (INSDC), GSA adopts four data objects (BioProject, BioSample, Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world, and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world.
Food Fraud in the EU
Authors: Montanari Francesco , Varallo Cesare , Pisanello Daniele 
Published: February 2017

By making the headlines in the major European newspapers in 2013, the horsemeat scandal impaired consumer confidence in the transparency of the European food chain to a significant extent. In spite of its negative economic impact on the European Union (EU) market, the scandal in question has stimulated an unprecedented reflection in the area of food fraud by the EU institutions, national authorities, other stakeholders as well as by members of academia and the legal profession in general.On an EU level, the European Commission swiftly responded to the scandal with the adoption of a wide-ranging action plan consisting of targeted policy, legislative and enforcement measures.
Disorder enabled band structure engineering of a topological insulator surface
Authors: Xu Yishuai , Chiu Janet , Miao Lin , He Haowei , Alpichshev Zhanybek , Kapitulnik A. , Biswas Rudro R. , Wray L. Andrew 
Published: February 2017

AbstractThree-dimensional topological insulators are bulk insulators with Z2 topological electronic order that gives rise to conducting light-like surface states. These surface electrons are exceptionally resistant to localization by non-magnetic disorder, and have been adopted as the basis for a wide range of proposals to achieve new quasiparticle species and device functionality. Recent studies have yielded a surprise by showing that in spite of resisting localization, topological insulator surface electrons can be reshaped by defects into distinctive resonance states. Here we use numerical simulations and scanning tunnelling microscopy data to show that these resonance states have significance well beyond the localized regime usually associated with impurity bands. At native densities in the model Bi2X3 (X=Bi, Te) compounds, defect resonance states are predicted to generate a new quantum basis for an emergent electron gas that supports diffusive electrical transport.
Bloch surface waves confined in one dimension with a single polymeric nanofibre
Authors: Wang Ruxue , Xia Hongyan , Zhang Douguo , Chen Junxue , Zhu Liangfu , Wang Yong , Yang Erchan , Zang Tianyang , Wen Xiaolei , Zou Gang , Wang Pei , Ming Hai , Badugu Ramachandram , Lakowicz Joseph R. 
Published: February 2017

AbstractPolymeric fibres with small radii (such as 125 nm) are delicate to handle and should be laid down on a solid substrate to obtain practical devices. However, placing these nanofibres on commonly used glass substrates prevents them from guiding light. In this study, we numerically and experimentally demonstrate that when the nanofibre is placed on a suitable dielectric multilayer, it supports a guided mode, a Bloch surface wave (BSW) confined in one dimension. The physical origin of this new mode is discussed in comparison with the typical two-dimensional BSW mode. Polymeric nanofibres are easily fabricated to contain fluorophores, which make the dielectric nanofibre and multilayer configuration suitable for developing a large range of new nanometric scale devices, such as processor–memory interconnections, devices with sensitivity to target analytes, incident polarization and multi-colour BSW modes.
A high performance lithium ion capacitor achieved by the integration of a Sn-C anode and a biomass-derived microporous activated carbon cathode
Authors: Sun Fei , Gao Jihui , Zhu Yuwen , Pi Xinxin , Wang Lijie , Liu Xin , Qin Yukun 
Published: February 2017

AbstractHybridizing battery and capacitor materials to construct lithium ion capacitors (LICs) has been regarded as a promising avenue to bridge the gap between high-energy lithium ion batteries and high-power supercapacitors. One of the key difficulties in developing advanced LICs is the imbalance in the power capability and charge storage capacity between anode and cathode. Herein, we design a new LIC system by integrating a rationally designed Sn-C anode with a biomass-derived activated carbon cathode. The Sn-C nanocomposite obtained by a facile confined growth strategy possesses multiple structural merits including well-confined Sn nanoparticles, homogeneous distribution and interconnected carbon framework with ultra-high N doping level, synergically enabling the fabricated anode with high Li storage capacity and excellent rate capability. A new type of biomass-derived activated carbon featuring both high surface area and high carbon purity is also prepared to achieve high capacity for cathode. The assembled LIC (Sn-C//PAC) device delivers high energy densities of 195.7 Wh kg−1 and 84.6 Wh kg−1 at power densities of 731.25 W kg−1 and 24375 W kg−1, respectively. This work offers a new strategy for designing high-performance hybrid system by tailoring the nanostructures of Li insertion anode and ion adsorption cathode.
Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia
Authors: Grütz Karen , Seibler Philip , Weissbach Anne , Lohmann Katja , Carlisle Francesca A. , Blake Derek J. , Westenberger Ana , Klein Christine , Grünewald Anne 
Published: February 2017

AbstractIn neuropathology research, induced pluripotent stem cell (iPSC)-derived neurons are considered a tool closely resembling the patient brain. Albeit in respect to epigenetics, this concept has been challenged. We generated iPSC-derived cortical neurons from myoclonus-dystonia patients with mutations (W100G and R102X) in the maternally imprinted ε-sarcoglycan (SGCE) gene and analysed properties such as imprinting, mRNA and protein expression. Comparison of the promoter during reprogramming and differentiation showed tissue-independent differential methylation. DNA sequencing with methylation-specific primers and cDNA analysis in patient neurons indicated selective expression of the mutated paternal SGCE allele. While fibroblasts only expressed the ubiquitous mRNA isoform, brain-specific SGCE mRNA and ε-sarcoglycan protein were detected in iPSC-derived control neurons. However, neuronal protein levels were reduced in both mutants. Our phenotypic characterization highlights the suitability of iPSC-derived cortical neurons with SGCE mutations for myoclonus-dystonia research and, in more general terms, prompts the use of iPSC-derived cellular models to study epigenetic mechanisms impacting on health and disease.
Multipath colourimetric assay for copper(II) ions utilizing MarR functionalized gold nanoparticles
Authors: Wang Yulong , Wang Limin , Su Zhenhe , Xue Juanjuan , Dong Jinbo , Zhang Cunzheng , Hua Xiude , Wang Minghua , Liu Fengquan 
Published: February 2017

AbstractWe use the multiple antibiotic resistance regulator (MarR), as a highly selective biorecognition elements in a multipath colourimetric sensing strategy for the fast detection of Cu2+ in water samples. The colourimetric assay is based on the aggregation of MarR-coated gold nanoparticles in the presence of Cu2+ ions, which induces a red-to-purple colour change of the solution. The colour variation in the gold nanoparticle aggregation process can be used for qualitative and quantitative detection of Cu2+ by the naked eye, and with UV–vis and smartphone-based approaches. The three analysis techniques used in the multipath colourimetric assay complement each other and provide greater flexibility for differing requirements and conditions, making the assay highly applicable for Cu2+ detection. Under optimal conditions, the Cu2+ concentration was quantified in less than 5 min with limits of detection for the naked eye, UV–vis and smartphone-based approaches of 1 μM, 405 nM and 61 nM, respectively. Moreover, the sensing system exhibited excellent selectivity and practical application for Cu2+ detection in real water samples. Thus, our strategy has great potential for application in on-site monitoring of Cu2+, and the unique response of MarR towards copper ions may provide a new approach to Cu2+ sensing.
Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain
Authors: Wilson Tony W. , Proskovec Amy L. , Heinrichs-Graham Elizabeth , O’Neill Jennifer , Robertson Kevin R. , Fox Howard S. , Swindells Susan 
Published: February 2017

AbstractImpairments in working memory are among the most prevalent features of HIV-associated neurocognitive disorders (HAND), yet their origins are unknown, with some studies arguing that encoding operations are disturbed and others supporting deficits in memory maintenance. The current investigation directly addresses this issue by using a dynamic mapping approach to identify when and where processing in working memory circuits degrades. HIV-infected older adults and a demographically-matched group of uninfected controls performed a verbal working memory task during magnetoencephalography (MEG). Significant oscillatory neural responses were imaged using a beamforming approach to illuminate the spatiotemporal dynamics of neuronal activity. HIV-infected patients were significantly less accurate on the working memory task and their neuronal dynamics indicated that encoding operations were preserved, while memory maintenance processes were abnormal. Specifically, no group differences were detected during the encoding period, yet dysfunction in occipital, fronto-temporal, hippocampal, and cerebellar cortices emerged during memory maintenance. In addition, task performance in the controls covaried with occipital alpha synchronization and activity in right prefrontal cortices. In conclusion, working memory impairments are common and significantly impact the daily functioning and independence of HIV-infected patients. These impairments likely reflect deficits in the maintenance of memory representations, not failures to adequately encode stimuli.
A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs
Authors: Neganova Irina , Chichagova Valeria , Armstrong Lyle , Lako Majlinda 
Published: February 2017

AbstractReprogramming of somatic cells to induced pluripotent stem cells (iPSCs) holds enormous promise for regenerative medicine. Reprogramming is a stepwise process with well-defined stages of initiation, maturation and stabilisation which are critically dependent on interactions between key pluripotency transcription factors, epigenetic regulators and signalling pathways. In this manuscript we have investigated the role of p38 MAPK signalling pathway and have shown a subpopulation- and phase-specific pattern of activation occurring during the initiation and maturation stage of reprogramming in partially and fully reprogrammed cells respectively. Downregulation of p38 MAPK activity via RNA interference or small molecule inhibitor led to cell accumulation in G1 phase of the cell cycle and reduced expression of cell cycle regulators during the initiation stage of reprogramming. This was associated with a significant downregulation of key pluripotency marker expression, disruption of mesenchymal to epithelial transition (MET), increased expression of differentiation markers and presence of partially reprogrammed cells which retained a typical gene expression profile of mesendodermal cells and were unable to progress to fully reprogrammed phenotype. Together our data indicate an important role for p38 MAPK activity in proliferation, MET progression and establishment of pluripotent phenotype, which are necessary steps for the development of human iPSCs.
Effects of nutritional and ambient oxygen condition on biofilm formation in Mycobacterium avium subsp. hominissuis via altered glycolipid expression
Authors: Totani Takahiro , Nishiuchi Yukiko , Tateishi Yoshitaka , Yoshida Yutaka , Kitanaka Hiromi , Niki Mamiko , Kaneko Yukihiro , Matsumoto Sohkichi 
Published: February 2017

AbstractMycobacterium aviumsubsp.hominissuis(MAH) is the major causative agent of nontuberculous mycobacteriosis, the representative case of environment-related infectious diseases the incidence of which is increasing in industrialized countries. MAH is found in biofilm in drinking water distribution system and residential environments. We investigated the effect of gaseous and nutritional conditions, and the role of glycopeptidolipids (GPLs) on biofilm-like pellicle formation in MAH. Pellicle formation was observed under 5% oxygen in Middlebrook 7H9 broth containing 0.2% glycerol and 10% albumin-dextrose-catalase enrichment but not under normoxia or in nutrient-poor media. An analysis of 17 environmental isolates revealed that hypoxia (5% oxygen) preferentially enhanced pellicle formation both in plastic plates and in glass tubes, compared with hypercapnia (5% carbon dioxide). Wild-type strains (WT) developed much thicker pellicles than GPL-deficient rough mutants (RM). WT bacterial cells distributed randomly and individually in contrast to that RM cells positioned linearly in a definite order. Exogenous supplementation of GPLs thickened the pellicles of RM, resulting in a similar morphological pattern to WT. These data suggest a significant implication of eutrophication and hypoxia in biofilm-like pellicle formation, and a functional role of GPLs on development of pellicles in MAH.
The reduction in the biomass of cyanobacterial N2 fixer and the biological pump in the Northwestern Pacific Ocean
Authors: Kim Dongseon , Jeong Jin-Hyun , Kim Tae-Wook , Noh Jae Hoon , Kim Hyung Jeek , Choi Dong Han , Kim Eung , Jeon Dongchull 
Published: February 2017

AbstractThe comparison of sediment trap data with physical and biogeochemical variables in the surface water column of the Tropical Northwestern Pacific Ocean (TNWPO) indicated that the magnitude of the springtime biological pump has reduced with time due to a corresponding decrease in the biomass of cyanobacterial N2 fixer. The decrease in the biomass of N2 fixer likely resulted from a reduction in phosphate concentrations in response to surface water warming and consequent shoaling of the mixed layer depth during the study period (2009−2014). The same reduction in biological pump was also observed during summer. However, the cause of the summer reduction remains uncertain and is worth assessing in future studies. Our findings have major implications for predicting future trends of the biological pump in the TNWPO, where significant warming has occurred.
Boreal pollen contain ice-nucleating as well as ice-binding ‘antifreeze’ polysaccharides
Authors: Dreischmeier Katharina , Budke Carsten , Wiehemeier Lars , Kottke Tilman , Koop Thomas 
Published: February 2017

AbstractIce nucleation and growth is an important and widespread environmental process. Accordingly, nature has developed means to either promote or inhibit ice crystal formation, for example ice-nucleating proteins in bacteria or ice-binding antifreeze proteins in polar fish. Recently, it was found that birch pollen release ice-nucleating macromolecules when suspended in water. Here we show that birch pollen washing water exhibits also ice-binding properties such as ice shaping and ice recrystallization inhibition, similar to antifreeze proteins. We present spectroscopic evidence that both the ice-nucleating as well as the ice-binding molecules are polysaccharides bearing carboxylate groups. The spectra suggest that both polysaccharides consist of very similar chemical moieties, but centrifugal filtration indicates differences in molecular size: ice nucleation occurs only in the supernatant of a 100 kDa filter, while ice shaping is strongly enhanced in the filtrate. This finding may suggest that the larger ice-nucleating polysaccharides consist of clusters of the smaller ice-binding polysaccharides, or that the latter are fragments of the ice-nucleating polysaccharides. Finally, similar polysaccharides released from pine and alder pollen also display both ice-nucleating as well as ice-binding ability, suggesting a common mechanism of interaction with ice among several boreal pollen with implications for atmospheric processes and antifreeze protection.
Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice
Authors: Hang Bo , Snijders Antoine M. , Huang Yurong , Schick Suzaynn F. , Wang Pin , Xia Yankai , Havel Christopher , Jacob Peyton , Benowitz Neal , Destaillats Hugo , Gundel Lara A. , Mao Jian-Hua 
Published: February 2017

AbstractThirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor environments after smoking. We investigated the effects of neonatal and adult THS exposure on bodyweight and blood cell populations in C57BL/6 J mice. At the end of neonatal exposure, THS-treated male and female mice had significantly lower bodyweight than their respective control mice. However, five weeks after neonatal exposure ended, THS-treated mice weighed the same as controls. In contrast, adult THS exposure did not change bodyweight of mice. On the other hand, both neonatal and adult THS exposure had profound effects on the hematopoietic system. Fourteen weeks after neonatal THS exposure ended, eosinophil number and platelet volume were significantly higher, while hematocrit, mean cell volume, and platelet counts were significantly lower compared to control. Similarly, adult THS exposure also decreased platelet counts and increased neutrophil counts. Moreover, both neonatal and adult THS exposure caused a significant increase in percentage of B-cells and significantly decreased percentage of myeloid cells. Our results demonstrate that neonatal THS exposure decreases bodyweight and that THS exposure induces persistent changes in the hematopoietic system independent of age at exposure. These results also suggest that THS exposure may have adverse effects on human health.
Virtual touch tissue imaging and quantification (VTIQ) in the evaluation of thyroid nodules: the associated factors leading to misdiagnosis
Authors: Sun Cheng-Yu , Lei Kai-Rong , Liu Bo-Ji , Bo Xiao-Wan , Li Xiao-Long , He Ya-Ping , Wang Dan , Ren Wei-Wei , Zhao Chong-Ke , Xu Hui-Xiong 
Published: February 2017

AbstractTo evaluate the associated factors leading to misdiagnosis with VTIQ for differentiation between benign from malignant thyroid nodules (TNs). The study included 238 benign TNs and 150 malignant TNs. Conventional ultrasound (US) features and VTIQ parameters were obtained and compared with the reference standard of histopathological and/or cytological results. Binary logistic regression analysis was performed to select independent variables leading to misdiagnosis. The maximum shear wave speed (SWS) (SWS-max), mean SWS (SWS-mean), SWS-ratio and standard deviation of SWS (SWS-SD) were significantly higher for malignant TNs compared with benign TNs (all P < 0.001). SWS-mean achieved the highest diagnostic performance with a cut-off value of 3.15 m/s. False positive rate was 13.4% (32/238) while false negative rate was 35.3% (53/150). Intranodular calcification (OR: 1.715) was significantly associated with false positive VTIQ findings, while nodule size (OR: 0.936) and echotexture of the thyroid gland (OR: 0.033) were negatively associated with them. Nodule depth (OR: 0.881) and TI-RADS category (OR: 0.563) were negatively associated with false negative VTIQ findings. These US characteristic of TNs should be taken into consideration when interpreting the results of VTIQ examinations.