bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tumor Suppressor Gene Product, Platelet‐Derived Growth Factor Receptor‐Like Protein Controls Chondrocyte Proliferation and Differentiation
Authors: Kawata Kazumi , Kubota Satoshi , Eguchi Takanori , Aoyama Eriko , Moritani Norifumi H. , Oka Morihiko , Kawaki Harumi , Takigawa Masaharu 
Published: April 2017

ABSTRACTThe platelet‐derived growth factor receptor‐like (PDGFRL) gene is regarded as a tumor suppressor gene. However, nothing is known about the molecular function of PDGFRL. In this study, we initially clarified its function in chondrocytes. Among all cell lines examined, the PDGFRL mRNA level was the highest in chondrocytic HCS‐2/8 cells. Interestingly, the proliferation of chondrocytic HCS‐2/8 cells was promoted by PDGFRL overexpression, whereas that of the breast cancer‐derived MDA‐MB‐231 cells was inhibited. Of note, in PDGFRL‐overexpressing HCS‐2/8 cells, the expression of chondrocyte differentiation marker genes, SOX9, ACAN, COL2A1, COL10A1, and ALP, was decreased. Moreover, we confirmed the expression of PDGFRL mRNA in normal cartilage tissue and chondrocytes. Eventually, the expression of PDGFRL mRNA in condrocytes except in the case of hypertrophic chondrocytes was demonstrated in vivo and in vitro. These findings suggest that PDGFRL plays the different roles, depending upon cell types. Particularly, in chondrocytes, PDGFRL may play a new and important role which is distinct from the function previously reported. J. Cell. Biochem. 118: 4033–4044, 2017. © 2017 Wiley Periodicals, Inc.
Effects of Ultraviolet Radiation on Glioma: Systematic Review
Authors: Pronin Savva , Koh Chan Hee , Hughes Mark 
Published: April 2017

ABSTRACTGlioblastoma multiforme is the most aggressive primary brain tumor. Treatment is largely palliative, with current strategies unable to prevent inevitable tumor recurrence. Implantable micro‐electromechanical systems are becoming more feasible for the management of several human diseases. These systems may have a role in detecting tumor recurrence and delivering localized therapies. One potential therapeutic tool is ultraviolet (UV) light. This systematic review assesses the effects of UV light on glioma cells. A total of 47 publications are included. The large majority were in vitro experiments conducted on human glioblastoma cell lines in monolayer. In these cells, UV light was shown to induce apoptosis and the expression of genes or activation of proteins that modulate cell death, repair, and proliferation. The nature and magnitude of cellular response varied by UV wavelength, dose, cell line, and time after irradiation. UVC (wavelength 100–280 nm) was most effective at inducing apoptosis, and this effect was dose dependent. The included studies had varied methodologies, complicating reconciliation of results. Further work will be required to determine the best regime of UV irradiation for therapeutic use. J. Cell. Biochem. 118: 4063–4071, 2017. © 2017 Wiley Periodicals, Inc.
Acute onset collagenous colitis associated with protein‐losing enteropathy
Authors: Nakaya Yuichiro , Kaku Hosokawa Sawako , Kataoka Yuki , Hirabayashi Masataka , Yamamoto Shuhei , Takasu Kosho , Kitamura Satoru , Omae Takahito , Yoshimatsu Yuki 
Published: April 2017

AbstractCollagenous colitis is a cause of chronic diarrhea. We report an atypical case of collagenous colitis, presenting with an acute onset, and associated with protein‐losing enteropathy. An 82‐year‐old woman was admitted with a 1 week history of nausea, appetite loss, and diarrhea. Serum albumin level was low. Protein leakage from the small intestine was found by a Technetium‐99m human serum albumin scintigraphy. We diagnosed the patient with collagenous colitis from pathology findings of multiple biopsies taken from the colon. This case implies that collagenous colitis should be considered in acute watery diarrhea, and that it can cause protein‐losing enteropathy.
Management of neuropathic pain
Authors: Nishikawa Noriko , Nomoto Masahiro 
Published: April 2017

AbstractNeuropathic pain is intractable pain caused by damage to the nervous system. Recent approval and expansion of the indications of a series of drugs are expected to improve the treatment strategies for neuropathic pain. Here, we present an outline of pain transmission pathways and relevant pharmacological effects, along with points to consider in the use of neuropathic pain medications according to the guidelines of Japan Society of Pain Clinicians. The content of this article is almost similar to my other Japanese article that was published in the Journal of the Japanese Society of Internal Medicine. Although complete recovery from pain may be difficult, pharmacotherapy can relieve pain, thereby improving the patients’ quality of life.
Metronidazole‐induced encephalopathy associated with treatment for liver abscesses
Authors: Hanji Yurika , Sasaki Yosuke , Matsumoto Yosuke , Maeda Tadashi , Urita Yoshihisa 
Published: April 2017

AbstractMetronidazole‐induced encephalopathy (MIE) is a rare condition in Japan. We report the case of a patient with MIE who presented with abducens paralysis and ataxia without underlying risk factors. A history of metronidazole (MNZ) administration and rapid improvement after MNZ discontinuation are important in making this diagnosis, and characteristic findings of magnetic resonance imaging support the diagnosis. MIE is expected to become common in Japan as the use of MNZ increases because of expanded insurance coverage. Therefore, MIE needs to be recognized as a differential diagnosis of the central nervous symptoms in patients taking MNZ.
Improving education and supervision of Queensland X‐ray Operators through video conference technology: A teleradiography pilot project
Authors: Rawle Marnie , Oliver Tanya , Pighills Alison , Lindsay Daniel 
Published: April 2017

AbstractIntroductionX‐ray Operator (XO) supervision in Queensland is performed by radiographers in a site removed from the XO site. This has historically been performed by telephone when the XO requires immediate help, as well as post‐examination through radiographer review and the provision of written feedback on images produced. This project aimed to improve image quality through the provision of real‐time support of XOs by the introduction of video conference (VC) supervision.MethodsA 6‐month pilot project compared image quality with and without VC supervision. VC equipment was installed in the X‐ray room at two rural sites, as well as at the radiographer site, to enable visual and oral supervision. The VC unit enabled visualisation of the X‐ray examination technique as it was being undertaken, as well as the images produced prior to transmission to the Picture Archiving and Communication System (PACS).ResultsStatistically significant improvement in image quality criteria measures were seen for patient positioning (P = 0.008), image quality (P < 0.001) and diagnostic value (P < 0.001) of images taken during this project. No statistically significant differences were seen during case level assessment in the inclusion of only appropriate imaging (P = 0.06), and the inclusion of unacceptable imaging (P = 0.06), however improvements were seen in both of these criteria. The survey revealed 24.6% of examinations performed would normally have involved the XO contacting the radiographer for assistance, although, assistance was actually provided in 88.3% of examinations.ConclusionThis project has demonstrated that significant improvement in image quality is achievable with VC supervision. A larger study with a control arm that did not receive direct supervision should be used to validate the findings of this study.
Reproducibility of three dimensional digital preoperative planning for the osteosynthesis of distal radius fractures
Authors: Yoshii Yuichi , Kusakabe Takuya , Akita Kenichi , Tung Wen Lin , Ishii Tomoo 
Published: April 2017

ABSTRACTA three‐dimensional (3D) digital preoperative planning system for the osteosynthesis of distal radius fractures was developed for clinical practice. To assess the usefulness of the 3D planning for osteosynthesis, we evaluated the reproducibility of the reduction shapes and selected implants in the patients with distal radius fractures. Twenty wrists of 20 distal radius fracture patients who underwent osteosynthesis using volar locking plates were evaluated. The 3D preoperative planning was performed prior to each surgery. Four surgeons conducted the surgeries. The surgeons performed the reduction and the placement of the plate while comparing images between the preoperative plan and fluoroscopy. Preoperative planning and postoperative reductions were compared by measuring volar tilt and radial inclination of the 3D images. Intra‐class correlation coefficients (ICCs) of the volar tilt and radial inclination were evaluated. For the implant choices, the ICCs for the screw lengths between the preoperative plan and the actual choices were evaluated. The ICCs were 0.644 (p < 0.01) and 0.625 (p < 0.01) for the volar tilt and radial inclination in the 3D measurements, respectively. The planned size of plate was used in all of the patients. The ICC for the screw length between preoperative planning and actual choice was 0.860 (p < 0.01). Good reproducibility for the reduction shape and excellent reproducibility for the implant choices were achieved using 3D preoperative planning for distal radius fracture. Three‐dimensional digital planning was useful to visualize the reduction process and choose a proper implant for distal radius fractures. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2646–2651, 2017.
Assessment of the Cr doping and size effects on the Raman‐active modes of rutile TiO2 by UV/Visible polarized Raman spectroscopy
Authors: Vásquez G. Cristian , Maestre David , Cremades Ana , Piqueras Javier 
Published: April 2017

The Raman signal is highly sensitive to lattice distortions, doping, size effects or excitation source, among other factors. The coexistence of these effects makes occasionally difficult the interpretation of variations in Raman spectra. In this work, size and Cr doping effects have been evaluated by the study of Raman spectra of different undoped and Cr‐doped rutile TiO2 samples. In the Raman study, two laser sources have been employed with wavelengths in the visible (633 nm) and UV (325 nm) respectively, which entail different surface and spectral sensitivities. Polarization effects have been also evaluated, by modifying the orientation of the probed microstructures with respect to the laser polarization. It has been found that Cr incorporation increases vibration modes at 110, 154, 700 and 810 cm−1, some of them showing strong dependence with the laser polarization. The relation of these vibration modes with a possible doping‐induced activation of the Raman‐inactive B1u and A2u modes, as well as the influence of size effects on the Raman spectra, is evaluated and discussed. Copyright © 2017 John Wiley & Sons, Ltd.
Raman spectra of nyerereite, gregoryite, and synthetic pure Na2Ca(CO3)2: diversity and application for the study micro inclusions
Authors: Golovin A. V. , Korsakov A. V. , Gavryushkin P. N. , Zaitsev A. N. , Thomas V. G. , Moine B. N. 
Published: April 2017

In this study, we present Raman spectra of pure synthetic hydrothermal orthorhombic Na2Ca(CO3)2 carbonate together with naturally occurring orthorhombic nyerereite (Na,K)2Ca(CO3)2 and hexagonal gregoryite (Na,K,Cax)2‐x(CO3) from Oldoinyo Lengai natrocarbonatites (Tanzania) to show the diversity of spectra and permit the use of Raman spectroscopy to identify these minerals in small inclusions. Synthetic orthorhombic Na2Ca(CO3)2 carbonate has only one type of Raman spectrum, which is independent of the crystallographic orientation. The Raman spectra of nyerereite can be divided into three types, depending on intensity of symmetric stretching ν1(CO3)2− vibrations in region 1070–1090 cm−1. All these nyerereite types have identical chemical compositions; thus, the differences in Raman spectra are likely to be related to crystallographic orientations. Some nyerereite Raman spectra can be erroneously interpreted as gregoryite because of similarity in peak position of strong ν1(CO3)2− band. However, the diagnostic features of the gregoryite Raman spectrum can be summarized as follows: (1) presence of a symmetric peak attributed to ν1(CO3)2− vibrations at 1078 cm−1; (2) presence of one broad band ν4(CO3)2− with a peak position at 702–707 cm−1; (3) a stronger band ν1(SO4)2− that occurs at 1003–1006 cm−1 and the presence of additional weaker bands ν2(SO4)2− and ν4(SO4)2− at 460–462 and 630–635 cm−1; and (4) a ν1(PO4)3− band that appears at 952–954 cm−1. Incorporation of significant amounts of additional cations (up to 0.5 apfu) and particularly K (up to 0.4 apfu) in natural nyerereites leads to a change in the commensurately modulated structure of pure Na2Ca(CO3)2 (P21ca), which becomes an incommensurately modulated structure (less ordered) with space group Cmcm; and these changes are reflected in a reduction of the number of Raman bands in symmetric stretching ν1(CO3)2− and inplane bending ν4(CO3)2− vibration regions or even the complete absence of the Raman bands in antisymmetric stretching ν3(CO3)2− and 2*ν2(CO3)2− vibration regions compared with pure Na2Ca(CO3)2. Copyright © 2017 John Wiley & Sons, Ltd.
Changes in the nutritional quality of five Mangifera species harvested at two maturity stages
Authors: Barbosa Gámez Ignacio , Caballero Montoya Karla P , Ledesma Noris , Sáyago Ayerdi Sonia G , García Magaña María de Lourdes , Bishop von Wettberg Eric J , Montalvo‐González Efigenia 
Published: April 2017

AbstractBACKGROUNDThere are 69 species of edible Mangifera recognized in Southeast Asia. Most of these species have not been characterized for nutritional properties. This paper describes the nutritional quality of the pulp of several Mangifera species – Mangifera casturi, Mangifera lalijiwa, Mangifera odorata, Mangifera zeylanica and two cultivars of Mangifera indica, ‘Tommy‐Kent’ and ‘Tommy Atkins’ – at two maturity stages.RESULTSThe results showed that nutritional quality varied with maturity stage and among species. The immature pulp of all species had higher content of total dietary fibre, vitamin C, vitamin E, total soluble polyphenols and antioxidant capacity. In mature pulp, the protein, ash, fat, soluble carbohydrate and B vitamin values were higher in all species. The species with the best nutritional quality were, in order from highest to lowest, M. casturi, M. odorata, M. zeylanica, M. indica cultivars and M. lalijiwa.CONCLUSIONThe fruit pulp of three species had higher nutritional quality at both maturity stages in comparison with M. indica cultivars. These other Mangifera species can be nutritionally important in communities facing food insecurity and have potential as emerging crops. The decline of these valuable species in their natural habitats is an increasing concern, and their nutritional properties justify greater efforts to protect them. © 2017 Society of Chemical Industry
Reconstruction of quadriceps function with composite free tissue transfers following sarcoma resection
Authors: Walley Kempland C. , Taylor Erin M. , Anderson Megan , Lozano‐Calderon Santiago , Iorio Matthew L. 
Published: April 2017

BACKGROUND AND OBJECTIVES Wide margin resection of a soft tissue sarcoma (STS) may require extensive removal of quadriceps muscle with or without the knee extensor mechanism. The objective of this study is to present present the use of a combined functional muscle transfer and soft tissue coverage through the use of chimeric anterolateral thigh flaps.METHODSPatients were retrospectively reviewed who underwent deep STS resection of the anterior compartment of the thigh with functional reconstruction of knee extension using a contralateral free anterolateral thigh (ALT) flap.RESULTSThree patients with an average age 53.6 years (range: 33‐66) were included. Average follow‐up was 82 weeks (76‐92 months). Full active extension was regained in 66% of patients with all patients regaining active extensor capabilities beyond 100°. The mean Knee Society Score was 83.3 (range; 76‐92) and Musculoskeletal Tumor Society Score 21.6 (range; 19‐21). Isometric knee extensor strength exceeded 4+/5 in all patients.CONCLUSIONFollowing soft tissue sarcoma resections of the lower extremity, chimeric anterolateral thigh flaps for restoration of knee extension can provide significant improvements in the potential for ambulation and regaining quadriceps function.
Using the 21‐gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial
Authors: Bear Harry D. , Wan Wen , Robidoux André , Rubin Peter , Limentani Steven , White Richard L. , Granfortuna James , Hopkins Judith O. , Oldham Dwight , Rodriguez Angel , Sing Amy P. 
Published: April 2017

ObjectiveWe hypothesized that the Oncotype Dx® 21‐gene Recurrence Score (RS) could guide neoadjuvant systemic therapy (NST) to facilitate breast conserving surgery (BCS) for hormone receptor positive (HR+) breast cancers.MethodsThis study enrolled patients with HR+, HER2‐negative, invasive breast cancers not suitable for BCS (size ≥ 2 cm). Core needle biopsy blocks were tested. For tumors with RS < 11, patients received hormonal therapy (NHT); patients with RS > 25 tumors received chemotherapy (NCT); patients with RS 11‐25 were randomized to NHT or NCT. Primary endpoint was whether 1/3 or more of randomized patients refused assigned treatment.ResultsSixty‐four patients were enrolled. Of 33 patients with RS 11‐25, 5 (15%) refused assignment to NCT. This was significantly lower than the 33% target (binomial test, P = 0.0292). Results for clinical outcomes (according to treatment received for 55 subjects) included successful BCS for 75% of tumors with RS < 11 receiving NHT, 72% for RS 11‐25 receiving NHT, 64% for RS 11‐25 receiving NCT, and 57% for RS > 25 receiving NCT.ConclusionsUsing the RS to guide NST is feasible. These results suggest that for patients with RS < 25 NHT is a potentially effective strategy.
Prognosis of primary tracheal tumor: A population‐based analysis
Authors: He Jiaxi , Shen Jianfei , Huang Jun , Dai Chenyang , Liang Wenhua , Ye Minhua , Kong Min , Chen Baofu , Zhu Chengchu , He Jianxing 
Published: April 2017

BackgroundTo elucidate the survival outcomes of tracheal tumors and to propose the potential stage of tracheal tumors.MethodAll cases of primary tracheal malignant tumors were extracted from the Surveillance, Epidemiology, and End Results database (SEER) during 1973‐2013. The overall survival was calculated using Kaplan‐Meier method. Cox regression was utilized to identify the prognostic factors.ResultA total of 287 cases were finally included. The median age of the patients was 59 years. Male patients accounted for 56.1%. The median survival was 57 months. Patients were categorized as Extension1 to 4 (E1‐4) and N0‐N3. E1 group with size <4 cm had the best prognosis. While E1 >4 cm, E2 and E3 <3 cm groups had similar outcomes, which were superior to E3 >3 cm group. E4 was the worst. N0 patients had ideal prognosis, which were better than N1 and N2 patients. The 3‐year survival rates of each T category were 74.7%, 57.3%, 28.1%, and 9.1%, respectively. In multivariate analysis, age, histology, tumor size, and extension were independent prognostic factors.ConclusionPatients with old age, large tumor size, advanced extension or no surgery may have worse prognosis. The proposed T category of tracheal tumor incorporating tumor extension and size helped to predict survival outcomes.
Nationwide trends and outcomes associated with neoadjuvant therapy in pancreatic cancer: An analysis of 18 243 patients
Authors: Youngwirth Linda M. , Nussbaum Daniel P. , Thomas Samantha , Adam Mohamed A. , Blazer Dan G. , Roman Sanziana A. , Sosa Julie A. 
Published: April 2017

BackgroundNeoadjuvant therapy has theoretical benefits for pancreatic cancer; however, its association with perioperative outcomes remains controversial. This study sought to evaluate variation in use of neoadjuvant therapy and outcomes following pancreatic resection.MethodsThe National Cancer Data Base (1998‐2011) was queried for patients with Stage I or II pancreatic adenocarcinoma who underwent pancreaticoduodenectomy. Subjects were classified by use of neoadjuvant chemotherapy and/or radiation therapy. Factors associated with use of neoadjuvant therapy were evaluated, and outcomes were compared.ResultsA 18 243 patients were identified; 1375 (7.5%) received neoadjuvant therapy. From 1998 to 2011, use of neoadjuvant therapy increased from 4.3% to 17.0%. Patients receiving neoadjuvant therapy were younger (63.1 vs 66.1 years, P = 0.001) and more likely to receive treatment at an academic facility (64.4% vs 51.4%, P < 0.001). Patients who received neoadjuvant therapy were more likely to have negative margins (77.8% vs 85.5%), negative lymph nodes (42.9% vs 59.3%) and tumors confined to the pancreas (65.8% vs 70.6%, all P < 0.001). Patients receiving neoadjuvant therapy had lower 30‐day mortality (2.0% vs 4.6%, P < 0.001) and readmission rates (7.4% vs 9.5%, P = 0.02).ConclusionsNeoadjuvant therapy use is increasing and associated with comparable short‐term outcomes. Further studies are needed to identify patients who would benefit from neoadjuvant therapy.
Microvascular anastomosis simulation using a chicken thigh model: Interval versus massed training
Authors: Schoeff Stephen , Hernandez Brian , Robinson Derek J. , Jameson Mark J. , Shonka David C. 
Published: April 2017

Objectives/HypothesisTo compare the effectiveness of massed versus interval training when teaching otolaryngology residents microvascular suturing on a validated microsurgical model.Study DesignOtolaryngology residents were placed into interval (n = 7) or massed (n = 7) training groups. The interval group performed three separate 30‐minute practice sessions separated by at least 1 week, and the massed group performed a single 90‐minute practice session. Both groups viewed a video demonstration and recorded a pretest prior to the first training session. A post‐test was administered following the last practice session.MethodsAt an academic medical center, 14 otolaryngology residents were assigned using stratified randomization to interval or massed training. Blinded evaluators graded performance using a validated microvascular Objective Structured Assessment of Technical Skill tool. The tool is comprised of two major components: task‐specific score (TSS) and global rating scale (GRS). Participants also received pre‐ and poststudy surveys to compare subjective confidence in multiple aspects of microvascular skill acquisition.ResultsOverall, all residents showed increased TSS and GRS on post‐ versus pretest. After completion of training, the interval group had a statistically significant increase in both TSS and GRS, whereas the massed group's increase was not significant. Residents in both groups reported significantly increased levels of confidence after completion of the study.ConclusionsSelf‐directed learning using a chicken thigh artery model may benefit microsurgical skills, competence, and confidence for resident surgeons. Interval training results in significant improvement in early development of microvascular anastomosis skills, whereas massed training does not.Level of EvidenceNA. Laryngoscope, 127:2490–2494, 2017