bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of incident poisoning, fracture and burn events using linked primary care, secondary care and mortality data from England: implications for research and surveillance
Authors: Baker Ruth , Tata Laila J , Kendrick Denise , Orton Elizabeth 
Published: January 2016

BackgroundEnglish national injury data collection systems are restricted to hospitalisations and deaths. With recent linkage of a large primary care database, the Clinical Practice Research Datalink (CPRD), with secondary care and mortality data, we aimed to assess the utility of linked data for injury research and surveillance by examining recording patterns and comparing incidence of common injuries across data sources.MethodsThe incidence of poisonings, fractures and burns was estimated for a cohort of 2 147 853 0–24 year olds using CPRD linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality data between 1997 and 2012. Time-based algorithms were developed to identify incident events, distinguishing between repeat follow-up records for the same injury and those for a new event.ResultsWe identified 42 985 poisoning, 185 517 fracture and 36 719 burn events in linked CPRD-HES-ONS data; incidence rates were 41.9 per 10 000 person-years (95% CI 41.4 to 42.4), 180.8 (179.8–181.7) and 35.8 (35.4–36.1), respectively. Of the injuries, 22 628 (53%) poisonings, 139 662 (75%) fractures and 33 462 (91%) burns were only recorded within CPRD. Only 16% of deaths from poisoning (n=106) or fracture (n=58) recorded in ONS were recorded within CPRD and/or HES records. None of the 10 deaths from burns were recorded in CPRD or HES records.ConclusionsIt is essential to use linked primary care, hospitalisation and deaths data to estimate injury burden, as many injury events are only captured within a single data source. Linked routinely collected data offer an immediate and affordable mechanism for injury surveillance and analyses of population-based injury epidemiology in England.
Bone Disease in Myeloma: The Claws of CRAB
Authors: Fonseca Rafael , Jain Tania 
Published: January 2016

Abstract
A dynamic approach to use bisphosphonates according to biomarkers of bone metabolism is presented in the Z-MARK study by Raje and colleagues. This is a major step forward toward a rational approach to bisphosphonate usage. Clin Cancer Res; 22(6); 1301–3. ©2016 AACR.
See related article by Raje et al., p. 1378
Plasminogen is a critical regulator of cutaneous wound healing
Authors: Sulniute Rima , Shen Yue , Guo Yong-Zhi , Fallah Mahsa , Ahlskog Nina , Ny Lina , Rakhimova Olena , Broden Jessica , Boija Hege , Moghaddam Aliyeh , Li Jinan , Wilczynska Malgorzata , Ny Tor 
Published: January 2016

SummaryWound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completion of wound healing and is a known reason for formation of chronic wounds. Previous studies have shown that wound closure is delayed in plasminogendeficient mice, and a role for plasminogen in dissection of extracellular matrix was suggested. However, our finding that plasminogen is transported to the wound by inflammatory cells early during the healing process, where it potentiates inflammation, indicates that plasminogen may also have other roles in the wound healing process. Here we report that plasminogen-deficient mice have extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation. Delayed formation of granulation tissue suggests that fibroblast function is impaired in the absence of plasminogen. Therefore, in addition to its role in the activation of inflammation, plasminogen is also crucial for subsequent steps, including resolution of inflammation and activation of the proliferation phase. Importantly, supplementation of plasminogen-deficient mice with human plasminogen leads to a restored healing process that is comparable to that in wild-type mice. Besides of being an activator of the inflammatory phase during wound healing, plasminogen is also required for the subsequent termination of inflammation. Based on these results, we propose that plasminogen may be an important future therapeutic agent for wound treatment.Supplementary Material to this article is available online at www.thrombosis-online.com.
MRI-based biomechanical parameters for carotid artery plaque vulnerability assessment
Authors: Teng Zhongzhao , Nederveen Aart J. , Lugt Aad Van der , Gillard Jonathan H. , Speelman Lambert 
Published: January 2016

SummaryCarotid atherosclerotic plaques are a major cause of ischaemic stroke. The biomechanical environment to which the arterial wall and plaque is subjected to plays an important role in the initiation, progression and rupture of carotid plaques. MRI is frequently used to characterize the morphology of a carotid plaque, but new developments in MRI enable more functional assessment of carotid plaques. In this review, MRI based biomechanical parameters are evaluated on their current status, clinical applicability, and future developments. Blood flow related biomechanical parameters, including endothelial wall shear stress and oscillatory shear index, have been shown to be related to plaque formation. Deriving these parameters directly from MRI flow measurements is feasible and has great potential for future carotid plaque development prediction. Blood pressure induced stresses in a plaque may exceed the tissue strength, potentially leading to plaque rupture. Multi-contrast MRI based stress calculations in combination with tissue strength assessment based on MRI inflammation imaging may provide a plaque stress-strength balance that can be used to assess the plaque rupture risk potential. Direct plaque strain analysis based on dynamic MRI is already able to identify local plaque displacement during the cardiac cycle. However, clinical evidence linking MRI strain to plaque vulnerability is still lacking. MRI based biomechanical parameters may lead to improved assessment of carotid plaque development and rupture risk. However, better MRI systems and faster sequences are required to improve the spatial and temporal resolution, as well as increase the image contrast and signal-to-noise ratio.
Arbitrary-Order Conservative and Consistent Remapping and a Theory of Linear Maps: Part II
Authors: Ullrich Paul A. , Devendran Dharshi , Johansen Hans 
Published: January 2016

AbstractThis paper extends on the first part of this series by describing four examples of 2D linear maps that can be constructed in accordance with the theory of the earlier work. The focus is again on spherical geometry, although these techniques can be readily extended to arbitrary manifolds. The four maps include conservative, consistent, and (optionally) monotone linear maps (i) between two finite-volume meshes, (ii) from finite-volume to finite-element meshes using a projection-type approach, (iii) from finite-volume to finite-element meshes using volumetric integration, and (iv) between two finite-element meshes. Arbitrary order of accuracy is supported for each of the described nonmonotone maps.
Geophysical estimation of shallow permafrost distribution and properties in an ice-wedge polygon-dominated Arctic tundra region
Authors: Dafflon Baptiste , Hubbard Susan , Ulrich Craig , Peterson John , Wu Yuxin , Wainwright Haruko , Kneafsey Timothy J. 
Published: January 2016

Shallow permafrost distribution and characteristics are important for predicting ecosystem feedbacks to a changing climate over decadal to century timescales because they can drive active layer deepening and land surface deformation, which in turn can significantly affect hydrologic and biogeochemical responses, including greenhouse gas dynamics. As part of the U.S. Department of Energy Next-Generation Ecosystem Experiments-Arctic, we have investigated shallow Arctic permafrost characteristics at a site in Barrow, Alaska, with the objective of improving our understanding of the spatial distribution of shallow permafrost, its associated properties, and its links with landscape microtopography. To meet this objective, we have acquired and integrated a variety of information, including electric resistance tomography data, frequency-domain electromagnetic induction data, laboratory core analysis, petrophysical studies, high-resolution digital surface models, and color mosaics inferred from kite-based landscape imaging. The results of our study provide a comprehensive and high-resolution examination of the distribution and nature of shallow permafrost in the Arctic tundra, including the estimation of ice content, porosity, and salinity. Among other results, porosity in the top 2 m varied between 85% (besides ice wedges) and 40%, and was negatively correlated with fluid salinity. Salinity directly influenced ice and unfrozen water content and indirectly influenced the soil organic matter content. A relatively continuous but depth-variable increase in salinity led to a partially unfrozen saline layer (cryopeg) located below the top of the permafrost. The cryopeg environment could lead to year-round microbial production of greenhouse gases. Results also indicated a covariability between topography and permafrost characteristics including ice-wedge and salinity distribution. In addition to providing insight about the Arctic ecosystem, through integration of lab-based petrophysical results with field data, this study also quantified the key controls on electric resistivity at this Arctic permafrost site, including salinity, porosity, water content, ice content, soil organic matter content, and lithologic properties.
Information Analysis in Educational Results Management
Authors: ��������  , Yakushkina A. 
Published: January 2016

The article lays out the approaches to optimization of educational results management by means of information analysis. The author unveils the content
and orientation of information analysis activities and reveals its organizational aspects within evaluation and assessment procedures. The article
indicates the value of information analysis at diff erent stages of working with evaluation and assessment data, introduces the concept of information
analysis product and shows translational channels for information analysis products.
Studying Italian para-industry: The case of Boris
Authors: Dagnino Gloria 
Published: January 2016

Abstract
This article examines labour in Italian contemporary film and television production industries through the case studies of Boris-la serie/Boris-the series (2007–2010) and Boris-il film/Boris-the movie (2011). In doing so, it applies two often considered opposite theoretical approaches: media production studies and textual analysis. The structure of the article is threefold. In the first section, Italian and international research addressing audio-visual media labour is reviewed, and organized into six thematic categories. The second section introduces and discusses Caldwell’s key notions of para-industry, shadow academy and media text. These constitute the theoretical framework underpinning the content and stylistic analysis of the case studies. The third section presents the analysis according to the previously exposed six categories. Results show that Boris’ representation of audio-visual media labour is essentially research-consistent. Moreover, the analysis reveals an issue overlooked by the literature: the prominence of political ties for accessing and enduring in Italian audio-visual industries.
Phylogenetic Analysis of PDV Movement Protein Compared to Bromoviridae Members as Justification of Possible Intercellular Movement
Authors: Kozieł Edmund , Otulak Katarzyna , Garbaczewska Grażyna 
Published: January 2016

Abstract
Prune dwarf virus (PDV) is a member of the Ilarvirus genus which is widely spread all over the world and causes considerable economic losses in nurseries and orchards. The virus is transmitted via seeds and pollen and through vegetative reproduction. However, the mechanisms of cell-to-cell and systemic transport of the virus are still not known. For the first time this study presents phylogenetic characterization of the movement protein (MP) of PDV isolates from the GenBank database in the context of geographic origin. The prepared analyses were based on a comparison of the whole amino acid sequence of the MP-PDV, the RNA-binding domain (RBD) in MP of PDV and MPs of four viruses from the Bromoviridae family with known transport mechanisms. Two different bioinformatic programs ClustalW and Jalview were used, and MP sequence variability up to 8% at the amino acid level among PDV isolates was confirmed. In the constructed phylogenetic trees the isolate sequences clustered in three conserved groups. Further analyses revealed similarity of the MP amino acid sequence of PDV and Alfalfa mosaic virus (AMV) of up to 34% and a 40% similarity of RBD between these viruses which suggested that the PDV transport mechanism may be on some level the same as that for AMV.
Isabelline Shrike Lanius isabellinus: A new species to the Bulgarian avifauna /Bledi srakoper Lanius isabellinus: Nova vrsta v bolgarski avifavni
Authors: Ignatov Assen , Mitev Daniel , Berkelder Rob , Poel Paul van der 
Published: January 2016

Pozvetek
Bledi srakoper Lanius isabellinus gnezdi v širokem pasu od Irana prek osrednje Azije in severne Kitajske do Mongolije. Prezimuje v osrednji in vzhodni Afriki, Pakistanu in Indiji. V Evropi se redno pojavlja, predvsem med koncem aprila in začetkom junija ter med začetkom septembra in koncem novembra. Pojavljata se (pod)vrsti isabellinus in phoenicuroides. V srednji in jugovzhodni Evropi so znana opazovanja iz Avstrije (3), Romunije (1) in Grčije (8). Avtorji prispevka predstavljajo prvi opazovanji za Bolgarijo, in sicer je bil 24. 5. 2010 na gori Slavjanka opazovan drugoletni samec nedoločene (pod)vrste, 28. 9. 2014 na jezeru Durankulak pa odrasel samec (pod)vrste isabellinus. Opazovanji je kot prvo in drugo za državo potrdila bolgarska komisija za redkosti BUNARCO.
Two ploidy levels of genetically delimited groups of the Calypogeia fissa complex (Jungermanniopsida, Calypogeiaceae)
Authors: Buczkowska Katarzyna , Hornik Bartosz , Czołpińska Magdalena 
Published: January 2016

Abstract
Calypogeia fissa is a suboceanic-mediterrean and amphiatlantic species, which comprises two subspecies: C. fissa subsp. fissa occurring in Europe and C. fissa subsp. neogea Schust. known from North America. Recently, within the European part of distribution, three groups (PS, PB and G) were distinguished with the aid of genetic and molecular markers. The flow cytometry results revealed that two of the detected groups of the European C. fissa, which are frequent in Poland (PS and PB), differ in ploidy level: the PS group is haploid, whereas the PB group is diploid. Isozyme pattern at two loci may suggest an allopolyploid origin of the diploid PB group.
Lactuca tatarica (Asteraceae) in embryonic dunes on Wolin Island (NW Poland)
Authors: W. A. Wojciech Kowalski , Łysko Andrzej , Popiela Agnieszka 
Published: January 2016

Abstract
By the end of the 19th century, Lactuca tatarica was reported for the first time from an adventive occurrence on the North Sea and Baltic Sea coasts. In Wolin Island, the species has become established in the natural habitat and is clearly spreading in recent years. The community with L. tatarica was studied currently on the western point of Wolin Island along the stretch between the mouth of the Świna (Swine) River and a newly constructed breakwater of the external harbour. The taxon occupies relatively low parts of the sandy elevations of dune ridges, in patches of the Honckenyo-Agropyretum juncei association (habitat 2110). Furthermore, L. tatarica has been reported in recent years from some locations in Świnoujście (Usedom (Uznam) Island), Międzyzdroje, Wisełka and Międzywodzie.
Frequencies of Single-Nucleotide Polymorphisms and Haplotypes of the SLCO1B1 Gene in Selected Populations of the Western Balkans
Authors: Daka Grapci A. , Dimovski A. J. , Kapedanovska A. , Vavlukis M. , Eftimov A. , Matevska Geshkovska N. , Labachevski N. , Jakjovski K. , Gorani D. , Kedev S. , Mladenovska Kristina 
Published: January 2016

Abstract
As a membrane influx transporter, organic anion- transporting polypeptide 1B1 (OATP1B1) regulates the cellular uptake of a number of endogenous compounds and drugs. The aim of this study was to characterize the diversity of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encoding this transporter in two ethnic groups populating the Western Balkans. The distribution of SCLO1B1 alleles was determined at seven variant sites (c.388A>G, c.521T>C, c.571T>C, c.597C>T, c.1086C>T, c.1463G>C and c.*439T>G) in 266 Macedonians and 94 Albanians using the TaqMan allelic discrimination assay. No significant difference in the frequencies of the single nucleotide polymorphisms (SNPs) was observed between these populations. The frequency of the c.521T>C SNP was the lowest (<13.7 and 12.2%, respectively), while the frequencies of all other SNP alleles were above 40.0%. Variant alleles of c.1463G>C and c.1086 C>T SNPs were not identified in either ethnic group. The haplotype analysis revealed 20 and 21 different haplotypes in the Macedonian and Albanian population, respectively. The most common haplotype in both ethnic groups, *1J/*1K/*1L, had a frequency of 39.0% and 26.6%, respectively. In both populations, the variant alleles of the functionally significant c.521T>C and c.388A>G SNPs existed in one major haplotype (*15/*16/*17), with a frequency of 8.6 and 2.4% in the Macedonian and Albanian subjects, respectively. In conclusion, sequence variations of the SLCO1B1 gene in the studied populations occur at high frequencies, which are similar to that of the Caucasian population. Further studies are needed to evaluate the clinical significance of these SNPs and/ or the major SLCO1B1 haplotypes they form for a large number of substrates and for susceptibility to certain diseases.
Investigation of Fasciculation and Elongation Protein ζ-1 (FEZ1) in Peripheral Blood Reveals Differences in Gene Expression in Patients with Schizophrenia
Authors: Vachev T.I. , Stoyanova V.K. , Ivanov H.Y. , Minkov I.N. , Popov N.T. 
Published: January 2016

Abstract
Schizophrenia (SZ) is a chronic neuropsychiatric disorder characterized by affective, neuromorphological and cognitive impairment, deteriorated social functioning and psychosis with underlying molecular abnormalities, including gene expression changes. Observations have suggested that fasciculation and elongation protein ζ-1 (FEZ1) may be implicated in the pathogenesis of schizophrenia. Nevertheless, our current knowledge of the expression of FEZ1 in peripheral blood of schizophrenia patients remains unclear. The purpose of this study was to identify the characteristic gene expression patterns of FEZ1 in peripheral blood samples from schizophrenia patients. We performed quantitative reverse-transcriptase (qRT-PCR) analysis using peripheral blood from drug-free schizophrenia patients (n = 29) and age and gender-matched general population controls (n = 24). For the identification of FEZ1 gene expression patterns, we applied a comparative threshold cycle (CT) method. A statistically significant difference of FEZ1 mRNA level was revealed in schizophrenia subjects compared to healthy controls (p = 0.0034). To the best of our knowledge, this study is the first describing a down-regulation of FEZ1 gene expression in peripheral blood of patients with schizophrenia. Our results suggested a possible functional role of FEZ1 in the pathogenesis of schizophrenia and confirmed the utility of peripheral blood samples for molecular profiling of psychiatric disorders including schizophrenia. The current study describes FEZ1 gene expression changes in peripheral blood of patients with schizophrenia with significantly down-regulation of FEZ1 mRNA. Thus, our results provide support for a model of SZ pathogenesis that includes the effects of FEZ1 expression.
The Relationship Between Transcript Expression Levels of Nuclear Encoded (TFAM, NRF1) and Mitochondrial Encoded (MT-CO1) Genes in Single Human Oocytes During Oocyte Maturation
Authors: Ghaffari Novin M. , Allahveisi Azra , Noruzinia M. , Farhadifar F. , Yousefian E. , Dehghani Fard A. , Salimi M. 
Published: January 2016

Abstract
In some cases of infertility in women, human oocytes fail to mature when they reach the metaphase II (MII) stage. Mitochondria plays an important role in oocyte maturation. A large number of mitochondrial DNA (mtDNA), copied in oocytes, is essential for providing adenosine triphosphate (ATP) during oocyte maturation. The purpose of this study was to identify the relationship between transcript expression levels of the mitochondrial encoded gene (MT-CO1) and two nuclear encoded genes, nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) in various stages of human oocyte maturation. Nine consenting patients, age 21-35 years old, with male factors were selected for ovarian stimulation and intracytoplasmic sperm injection (ICSI) procedures. mRNA levels of mitochondrial- related genes were performed by singlecell TaqMan® quantitative real-time polymerase chain reaction (qRT-PCR). There was no significant relationship between the relative expression levels in germinal vesicle (GV) stage oocytes (p = 0.62). On the contrary, a significant relationship was seen between the relative expression levels of TFAM and NRF1 and the MT-CO1 genes at the stages of metaphase I (MI) and MII (p = 0.03 and p = 0.002). A relationship exists between the transcript expression levels of TFAM and NRF1, and MT-CO1 genes in various stages of human oocyte maturation.
Monoclonal antibody therapeutics as potential interferences on protein electrophoresis and immunofixation
Authors: Willrich Maria Alice V. , Ladwig Paula M. , Andreguetto Bruna D. , Barnidge David R. , Murray David L. , Katzmann Jerry A. , Snyder Melissa R. 
Published: January 2016

AbstractThe use of therapeutic recombinant monoclonal antibodies (mAbs) has triggered concerns of mis-diagnosis of a plasma cell dyscrasia in treated patients. The purpose of this study is to determine if infliximab (INF), adalimumab (ADA), eculizumab (ECU), vedolizumab (VEDO), and rituximab (RITU) are detected as monoclonal proteins by serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE).Pooled normal sera were spiked with various concentrations (ranging from trough to peak) of INF, ADA, ECU, VEDO and RITU. The peak concentration for VEDO and RITU was also added to samples with known monoclonal gammopathies. All samples were analyzed by SPEP (Helena Laboratories) and IFE (Sebia); sera containing peak concentrations of mAbs were reflexed to electrospray-time-of-flight mass spectrometry (AbSciex Triple TOF 5600) for the intact light chain monoclonal immunoglobulin rapid accurate mass measurement (miRAMM).For all mAbs tested, no quantifiable M-spikes were observed by SPEP at any concentration analyzed. Small γ fraction abnormalities were noted on SPEP for VEDO at 300 μg/mL and RITU at 400 μg/mL, with identification of small IgG κ proteins on IFE. Using miRAMM for peak samples, therapeutic mAbs light chain accurate masses were identified above the polyclonal background and were distinct from endogenous monoclonal gammopathies.MAbs should not be easily confounded with plasma cell dyscrasias in patients undergoing therapy except when a SPEP and IFE are performed within a couple of days from infusion (peak). In ambiguous cases the use of the miRAMM technology could precisely identify the therapeutic mAb distinct from any endogenous monoclonal protein.