bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthodontic management of severe inversely impacted maxillary central incisors: a case series
Authors: Maruya Yuriko , Hino Ryoko , Tadano Manami , Hoshikawa Seira , Otake Shinji , Chiba Yuta , Saito Kan 
Published: October 2024

BackgroundAbnormal positioning and dislocation of the central incisor can disturb tooth eruption. Generally, inversely impacted maxillary central incisors do not erupt naturally. Performing traction and applied extrusion of an inversely impacted maxillary central incisor with a high inclination angle of the crown is challenging. This study aimed to examine the possibility of orthodontic treatment for severely inversely impacted maxillary central incisors in a series of case studies.MethodsThe inclination angle of the tooth crown, curvature of the tooth root, and length of the formed tooth root were measured using radiography. The teeth were then fenestrated and traction was applied using a lingual arch appliance with elastics.ResultsThe average crown axis inclination was 113°, the degree of root curvature was 97.3°, and the root formation was 36.1%. Although the crown axis inclination and root curvature were severe, all the incisors were aligned in the correct position as vital teeth through surgical and orthodontic treatments.ConclusionsTraction should be performed in the early period of incisor development when root formation is not progressing, regardless of the tooth angle.
Quilombola women from Jequitinhonha (Minas Gerais, Brazil) and access to water and sanitation in the context of COVID-19: a matter of human rights
Authors: Neves-Silva Priscila , Schall Brunah , Gonçalvez Flora Rodrigues , Alves Estela Macedo , dos Santos Sebastiana Rodrigues , Valente Polyana Aparecida , Pimenta Denise Nacif , Heller Léo 
Published: October 2024

IntroductionIn Brazil there are currently 3,475 certified quilombo communities, reminiscent of Black communities founded by African enslaved people. In the Jequitinhonha Valley, a semi-arid region located in northeastern Minas Gerais State, Brazil, there are approximately 80 established communities, mostly in hard-to-reach areas with lack of access to water and sanitation services.MethodsUsing the analytical framework of Human Rights to Water and Sanitation (HRWS) and with a gender perspective, this research aimed to analyze how access to water and sanitation occurs in two remaining communities of quilombos (Córrego do Narciso and Córrego do Rocha) located in the Jequitinhonha Valley and how lack of access to these services impacts the health and lifestyle of the population, especially during the COVID-19 pandemic. The study used qualitative methods. Data was collected using individual interviews and focus groups. The data was analyzed using content analyses technique.ResultsThe results showed that access to water and sanitation in both communities did not respect the HRWS normative content and the lack of access impacted the lifestyle—the economic, cultural and social traditional activities-and the health of the population, especially for women. During COVID-9 pandemic access to water became even more difficult because the supply by water truck was discontinued producing more insecurity as people in the communities, especially women, needed to go to the city to buy water and food and could not keep isolation.DiscussionPublic policies on access to water for rural populations, especially quilombolas, if guided by the HRWS framework and interwoven with the gender perspective, could ensure guaranteed quality of life for women and can strength their entitlements within their territories.
Case Report: Custom made 3D implants for glenoid tumor reconstruction should be designed as reverse total shoulder arthroplasty
Authors: Evrard Robin , Ledoux Antoine , Docquier Pierre-Louis , Geenens Florine , Schubert Thomas 
Published: October 2024

Background and objectivesIsolated bone tumors of the glenoid are exceedingly rare occurrence and pose a substantial surgical challenge. 3D printing technology has been proved to be a reliable tool to reconstruct complex anatomical part of the skeleton. We initially used this technology to reconstruct the glenoid component of the shoulder in a hemiarthroplasty configuration. We subsequently changed to a reverse shoulder arthroplasty.MethodsTwo patients were reconstructed with a hemiarthroplasty and 2 with a reverse configuration. Patients files were reviewed for radiographic analysis, pain and function scores.ResultsMean follow-up was 36.44 ± 16.27 months. All patients are alive and disease free. The two patients who benefitted from a hemiarthroplasty demonstrated a rapid deterioration of the proximal humeral articular surface. Given their pain and function scores, they subsequently required revision towards a total shoulder arthroplasty. Following this conversion, one patient presented a shoulder dislocation requiring surgical reintervention. We did not observe any loosening or infection in this short series.ConclusionsCustom made glenoid reconstruction should be designed as a reverse shoulder arthroplasty given the mechanical constrains on the proximal humerus and the extent of the surgery invariably damaging the suprascapular neurovascular bundle.
Progression of cyclosporine A-blood levels in experimental cats receiving a high-dose treatment protocol
Authors: Rösch Sarah , Frommeyer Anna , Schulte Bocholt Jenny , Grote-Koska Denis , Brand Korbinian , Mischke Reinhard 
Published: October 2024

BackgroundCyclosporine A (CsA) is used as a steroid-sparing or alternative immunosuppressing agent in cats with various immune-mediated diseases such as immune-mediated hemolytic anemia. Daily treatment dosages of 5–20 mg/kg have been described. Interindividual variations in CsA blood levels are known to occur. To determine when steady-state conditions are reached and thus the earliest advisable time for monitoring CsA blood levels during the course of treatment, a prospective experimental study was conducted in six healthy adult Domestic Shorthair cats.Materials and methodsCats were treated with an oral dosage of 7 mg/kg CsA q 12 h for 10 days. On days 1, 2, 3, 5, 7, and 10 after the start of CsA administration (i.e., after 1, 3, 5, 9, 13, and 19 CsA administrations), EDTA blood was collected to measure the CsA level 12 h after the CsA administration (trough values) using high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS/MS).ResultsStatistical analysis revealed a significant increase in mean CsA blood levels up to day 5 (2,050 ± 964.2 ng/mL [mean ± SD], 832–3,203 ng/mL [minimum–maximum]; repeated-measures ANOVA: p = 0.0021), while values on days 5 and 7 did not differ significantly from CsA concentrations on day 10. CsA concentrations showed markedly interindividual variability.ConclusionCyclosporine A blood levels reached a steady state on day 5 of high dosages of CsA q 12 h (i.e., after nine CsA administrations), indicating that this time point is suitable for monitoring blood levels in clinical patients. Results confirmed the well-known remarkable interindividual variability of CsA, indicating the need for treatment monitoring. The assessed treatment regime resulted in significantly higher mean CsA trough levels than the target range for immunosuppressive therapy (200–600 ng/mL).
Methods of behavioral testing in dogs: a scoping review and analysis of test stimuli
Authors: Moser Ariella Y. , Welch Mitchell , Brown Wendy Y. , McGreevy Paul , Bennett Pauleen C. 
Published: October 2024

BackgroundBehavioral testing is widely used to measure individual differences in behavior and cognition among dogs and predict underlying psychological traits. However, the diverse applications, methodological variability, and lack of standardization in canine behavioral testing has posed challenges for researchers and practitioners seeking to use these tests. To address these complexities, this review sought to synthesize and describe behavioral testing methods by creating a framework that uses a “dog-centric” perspective to categorize the test stimuli used to elicit responses from dogs.MethodsA scoping review was conducted to identify scientific literature that has reported behavioral testing to assess psychological traits in dogs. Five online databases were systematically searched. Following this, an inductive content analysis was conducted to evaluate and summarize the behavioral testing methods in the literature.ResultsA total of 392 publications met the selection criteria and were included in the analysis, collectively reporting 2,362 behavioral tests. These tests were individually evaluated and categorized. Our content analysis distinguished 29 subcategories of behavioral testing stimuli that have been used, grouped into three major categories: human-oriented stimuli; environmental stimuli; and motivator-oriented stimuli.ConclusionDespite the methodological heterogeneity observed across behavioral testing methods, our study identified commonalities in many of the stimuli used in test protocols. The resulting framework provides a practical overview of published behavioral tests and their applications, which may assist researchers in selecting and designing appropriate tests for their purposes.
Phenotypic characterization and quality of life of Labradoodles with idiopathic epilepsy and epilepsy of unknown cause
Authors: Mandigers Paul J. J. , Meijs Simone E. , Plonek Marta , Santifort Koen M. , Diaz Espineira M. Montserrat 
Published: October 2024

IntroductionIdiopathic epilepsy (IE) is a common chronic neurological disorder in dogs. Breed specific knowledge on semiology, age of onset (AoO), seizure frequency, response to treatment, and Quality of Life (QoL) scores for both dog and owner are important. The Labradoodle is originally a cross between the Labrador Retriever and Standard Poodle. The aim of this study was to describe in detail the epilepsy, that is recognized in this designer breed.MethodAn online survey was distributed through several platforms to owners of Labradoodles. Only Labradoodles, either registered as such or bred as a Labradoodle were included. To classify the Labradoodles in a TIER level of confidence the criteria of the International Veterinary Task Force were used.ResultsForty labradoodles were included. Thirty-three Labradoodles were classified as IE or suspected IE cases and appeared to have an AoO of 2.3 ± 1.3 years, and a seizure frequency of 5.4 ± 6.5 seizures/year (range 0–25). Seven dogs were classified as EUC, two dogs started before 6 months of age, and five dogs had their first seizures at 8.4 ± 1.2 years of age. The seizure frequency for all EUC dogs was 5.0 ± 3.0 seizures/year (range 0–11). Stress, for both the (suspected) IE and EUC cases, was the most frequently reported seizure precipitating factor (95% of the dogs). AoO and seizure frequency did not seem to be influenced by type of housing, type of owner, or the dog’s character as interpreted by the owner. Cluster seizures (CS) were seen in 33% and status epilepticus (SE) in 10% of the included Labradoodles. Many dogs did not need treatment (38%) or only one anti-seizure medication (43%), in which case they tended to respond favorably to treatment. QoL scores were high for both dog (8.3 ± 1.8) and owner (7.3 ± 2.2).DiscussionCompared to the progenitor breeds, epilepsy of Labradoodles is phenotypically like that of the Standard Poodle, except for the existence CS and SE in the Labradoodle. The epilepsy seen in this designer breed has a favorable outcome compared to several other breeds.
Inertial measurement unit technology for gait detection: a comprehensive evaluation of gait traits in two Italian horse breeds
Authors: Asti Vittoria , Ablondi Michela , Molle Arnaud , Zanotti Andrea , Vasini Matteo , Sabbioni Alberto 
Published: October 2024

IntroductionThe shift of the horse breeding sector from agricultural to leisure and sports purposes led to a decrease in local breeds’ population size due to the loss of their original breeding purposes. Most of the Italian breeds must adapt to modern market demands, and gait traits are suitable phenotypes to help this process. Inertial measurement unit (IMU) technology can be used to objectively assess them. This work aims to investigate on IMU recorded data (i) the influence of environmental factors and biometric measurements, (ii) their repeatability, (iii) the correlation with judge evaluations, and (iv) their predictive value.Material and methodsThe Equisense Motion S® was used to collect phenotypes on 135 horses, Bardigiano (101) and Murgese (34) and the data analysis was conducted using R (v.4.1.2). Analysis of variance (ANOVA) was employed to assess the effects of biometric measurements and environmental and animal factors on the traits.Results and discussionVariations in several traits depending on the breed were identified, highlighting different abilities among Bardigiano and Murgese horses. Repeatability of horse performance was assessed on a subset of horses, with regularity and elevation at walk being the traits with the highest repeatability (0.63 and 0.72). The positive correlation between judge evaluations and sensor data indicates judges’ ability to evaluate overall gait quality. Three different algorithms were employed to predict the judges score from the IMU measurements: Support Vector Machine (SVM), Gradient Boosting Machine (GBM), and K-Nearest Neighbors (KNN). A high variability was observed in the accuracy of the SVM model, ranging from 55 to 100% while the other two models showed higher consistency, with accuracy ranging from 74 to 100% for the GBM and from 64 to 88% for the KNN. Overall, the GBM model exhibits the highest accuracy and the lowest error. In conclusion, integrating IMU technology into horse performance evaluation offers valuable insights, with implications for breeding and training.
Цифровые валюты центральных банков как инструмент государственного управления внешнеэкономической деятельностью
Authors: Лукичев К.Е. 
Published: October 2024

В статье рассматриваются цифровые валюты центральных банков, представляющие собой новую, более прогрессивную форму законных платежных средств, и их место в механизме организации внешнеэкономической деятельности в условиях беспрецедентного санкционного давления.
The article examines the digital currencies of central banks, which represent a new, more progressive form of legal means of payment, and their place in the mechanism of organizing foreign economic activity in the face of unprecedented sanctions pressure.
Перспективы устойчивого развития жилищно-коммунального хозяйства
Authors: Зуденкова С.А. 
Published: October 2024

Возрастающие требования к содержанию развития экономики и отдельных отраслей, обусловленные принятием обязательств по участию в достижении целей устойчивого развития, являются одним из факторов, определяющим состояние и перспективы развития предприятий и организаций ЖКХ. В статье рассмотрены цели и задачи развития ЖКХ, их взаимосвязь с целями устойчивого развития; особенности ЖКХ, влияющие на реализацию принципов устойчивого развития, а также предложены меры по совершенствованию механизмов функционирования ЖКХ.
The increasing requirements for the content of the development of the economy and individual industries, due to the assumption of obligations to participate in the achievement of sustainable development goals, are one of the factors that determine the state and prospects for the development of enterprises and organizations of housing and communal services. The article considers the goals and objectives of the development of housing and communal services, their interrelation with the goals of sustainable development; the features of housing and communal services that affect the implementation of the principles of sustainable development, and also proposes measures to improving the mechanisms for the functioning of housing and communal services.
Familial Renal Glucosuria and Potential Pharmacogenetic Impact on SGLT2 Inhibitors
Authors: Allaire Patrick , Fox Jamie , Kitchner Terrie , Gabor Rachel , Folz Connie , Bettadahalli Shankar , Hebbring Scott 
Published: October 2024

Background:
Renal glucosuria is a rare inheritable trait caused by loss-of-function variants in the gene that encodes SGLT2 (i.e., SLC5A2). The genetics of renal glucosuria is poorly understood and even less is known on how loss-of-function variants in SLC5A2 may affect response to SGLT2 inhibitors, a new class of medication gaining popularity to treat diabetes by artificially inducing glucosuria.

Methods:
We used two biobanks that link genomic with electronic health record data to study the genetics of renal glucosuria. This included 245,394 participants enrolled in the All of Us (AoU) Research Program and 11,011 enrolled in Marshfield Clinic’s Personalized Research Project (PMRP). Association studies in AoU and PMRP identified 10 variants that reached an experiment-wise Bonferroni threshold in either cohort, nine were novel. PMRP was further used as a recruitment source for a prospective SGLT2 pharmacogenetic trial. During a glucose tolerance test, the trial measured urine glucose concentrations in 15 SLC5A2 variant-positive individuals and 15 matched wild types with and without an SGLT2 inhibitor.

Results:
This trial demonstrated that carriers of SLC5A2 risk variants may be more sensitive to SGLT2 inhibitors compared to wild types (P=0.075). Based on population data, 2% of an ethnically diverse population carry rare variants in SLC5A2 and are at risk for renal glucosuria.

Conclusions:
As a result, 2% of individuals being treated with SGLT2 inhibitors may respond differently to this new class of medication compared to the general population suggesting a larger investigation into SLC5A2 variants and SGLT2 inhibitors is needed.
Ta'lîm Kitāb Nubdzah Al-Bayān Li Tarqiyah Mahārah Al Qiraāh Al ‘Arabiyah
Authors: Rosi Fathor , Azhara Siti , Ramadhan Yusfar 
Published: October 2024

<p style="text-align: justify;" dir="ltr"><span> </span><span>Arabic is an important part of the learning curriculum so that Arabic is made the official language at educational foundations, as well as at the Al-Amien Tegal Prenduan Islamic Boarding School. At this Islamic boarding school, the principles of learning Arabic are applied through the book Nubdzatul Bayan which consists of five volumes and a supplement. The aim of this research is to learn the rules of the Arabic language using the Nubdzatul Bayan book in order to improve the reading skills of Arabic texts for beginner students. The research method used is qualitative, with data collection techniques in the form of interviews, observation and documentation, with the research object being the students. The research results show that the strategy for learning Arabic rules using the Nubdzatul Bayan book is carried out through deductive methods and question and answer methods, where the teacher plays an important role in the learning process. First, the teacher writes the rules of Nahwu and Sharaf on the board along with examples of numbers in Arabic, Face-to-face learning is limited to only 3 hours per day, while learning evaluation includes daily, weekly, monthly and annual evaluations carried out using written tests and oral tests. Thus, this research provides insight into the effectiveness of using the Nubdzatul Bayan book in teaching Arabic language rules and improving Arabic text reading skills for beginner students at the Al-Amien Tegal Prenduan Islamic Boarding School.</span></p>
Al Jinās Dan Al Saja’ Fii Kitāb Washāya Al Abā Li Al Abnā
Authors: Silmy Ahmad Nahidl , Awaliyah Nurul Aida , Setiyadi Alif Cahya , Isnainurrohman Abdillah 
Published: October 2024

<p style="text-align: justify;"><span>The study of rhetoric is one of the sciences that studies how to process words or sentences in the Arabic language that are beautiful because they have clear meanings, and the style of the language used must be in accordance with the situation and conditions. There are three divisions in rhetoric: the science of meanings, the science of eloquence, and the science of ingenuity. In the science of ingenuity, the researcher chose alliteration and assonance. The aims of this study are: 1.Definition How many Jinas and Sajak in the book of commandments of fathers to children. 2.Definition of the types of Jinas and Sajak in the book Fathers' Commandments to Sons. The library study is based on reading books, magazines, or other research sources to collect data, and the researcher needs deep thinking to get a good research result, then she reads the books and continues to analyze the books in terms of rhetoric.</span></p>
Uslub Istiārah in the Qur'an According to Tafsir Experts and Its Implications for Balāghah Learning
Authors: Abdurahman Rizki , Rohanda Rohanda , Atha Yusuf Ali Shaleh , Sabarudin Ikbal , Hilmi Irpan 
Published: October 2024

The purpose of this study is to inventory and analyze Qur'anic verses containing uslub istiarah tamtsiliyyah according to exegetes and their implications for balagha learning. The method used in this study is qualitative descriptive with a literature study approach. Primary data sources are obtained from Kitab <em>shafwat al-tafasir </em>and<em> al-tafsir al-Munir. </em>Secondary sources are obtained from articles, books, books that are relevant to the research theme. Data collection techniques are carried out with documentation. While the data analysis technique is carried out by descriptive analysis through stages: (1) collecting and analyzing the verses of istiarah tamtsiliyyah in the Qur'an according to tafisr experts, and (2) describing the implications for learning balaghah. Referring to the results of research based on those obtained in this study that the results of this study show that there are 53 verses of the Qur'an that contain uslub isti'arah tamtsiliyyah in the view of interpreters. The results of this research data have significant implications for efforts to improve and develop balaghah learning materials based on Quranic studies. The problem in this study is limited to the focus of research on Qur'anic verses that contain isti'arah tamtsiliyyah in the Qur'an according to exegetes.
Idārah Tanfîdz Manhāj Ta’lîm Al Lughah Al ‘Arabiyyah Fî Al Madrasah Al ‘Āliyah Al Namûdzajiyyah Zainul Hasan Genggong Probolinggo
Authors: Shobirin Shobirin , Abidin Munirul , Syuhadak Syuhadak 
Published: October 2024

The curriculum is of the utmost importance. It offers a basic structure that directs the process of learning. It is essential that the curriculum be applied accurately and successfully. Ensuring that learning objectives are satisfied and content is successfully communicated to students is ensured by a robust curriculum implementation. The following are the objectives of this research: 1. The purpose of this study is to identify and characterise the Arabic curriculum implementation management methodology used at Probolinggo's Zainul Hasan Genggong methodology High School. The success of the Arabic curriculum implementation management strategy in helping pupils acquire the language will next be examined. Lastly, it will offer suggestions for enhancement based on the research findings to raise the standard of management for the execution of the Arabic curriculum at Zainul Hasan Genggong Model High School in in Probolinggo.This study uses a qualitative descriptive methodology, gathering information via documentation, interviews, and observation.The study's findings unequivocally showed that the curriculum was successfully implemented and backed by a strong human resource base, cutting-edge teaching strategies, and infrastructure. Leadership dedication, teaching team collaboration, the availability of learning materials, motivation, and student involvement are factors that impact how well a curriculum is implemented. Two of the challenges are different student aptitude levels and scheduling limits. The study suggested hiring more qualified teachers, upgrading the facilities and infrastructure, and utilising information technology that is pertinent to learning Arabic.