bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographic variation in host fish use and larval metamorphosis for the endangered dwarf wedgemussel
Authors: St. John White Barbara , Paola Ferreri C. , Lellis William A. , Wicklow Barry J. , Cole Jeffrey C. 
Published: August 2017

AbstractHost fishes play a crucial role in survival and dispersal of freshwater mussels (Unionoida), particularly rare unionids at conservation risk. Intraspecific variation in host use is not well understood for many mussels, including the endangered dwarf wedgemussel (Alasmidonta heterodon) in the USA.Host suitability of 33 fish species for dwarf wedgemussel glochidia (larvae) from the Delaware and Connecticut river basins was tested in laboratory experiments over 9 years. Relative suitability of three different populations of a single host fish, the tessellated darter (Etheostoma olmstedi), from locations in the Connecticut, Delaware, and Susquehanna river basins, was also tested.Connecticut River basinA. heterodonmetamorphosed into juvenile mussels on tessellated darter, slimy sculpin (Cottus cognatus), and Atlantic salmon (Salmo salar) parr. Delaware River basin mussels metamorphosed using these three species, as well as brown trout (Salmo trutta), banded killifish (Fundulus diaphanus), mottled sculpin (Cottus bairdii), striped bass (Morone saxatilis), and shield darter (Percina peltata). Atlantic salmon, striped bass, and sculpins were highly effective hosts, frequently generating 5+ juveniles per fish (JPF) and metamorphosis success (MS; proportion of attaching larvae that successfully metamorphose) ≥ 0.4, and producing juveniles in repeated trials.In experiments on tessellated darters, mean JPF and MS values decreased as isolation between the mussel source (Connecticut River) and each fish source increased; mean JPF = 10.45, 6.85, 4.14, and mean MS = 0.50, 0.41, and 0.34 in Connecticut, Delaware, and Susquehanna river darters, respectively. Host suitability of individual darters was highly variable (JPF = 2–11; MS = 0.20–1.0).The results show that mussel–host fish compatibility inA. heterodondiffers among Atlantic coastal rivers, and suggest that hosts including anadromous Atlantic salmon and striped bass may help sustainA. heterodonin parts of its range. Continued examination of host use variation, migratory host roles, and mussel–fish interactions in the wild is critical in conservation ofA. heterodonand other vulnerable mussel species.
Stability Analysis of Periodic Solution for a Complex‐valued Neural Networks With Bounded and Unbounded Delays
Authors: Du Bo 
Published: August 2017

AbstractThis paper is devoted to investigating a class of complex‐valued neural networks with bounded and unbounded delays. By means of Mawhin's continuation theorem, some criteria on existence and uniqueness of periodic solution are established for the complex‐valued neural networks. By constructing an appropriate Lyapunov‐Krasovskii functional and M−matrix theory, some sufficient conditions are derived for the global exponential stability of periodic solutions to the complex‐valued neural networks. Finally, two numerical examples are given to show the effectiveness and merits of the present results.
Malformations Surveillance: Comparison between Findings at Birth and Age 1 Year
Authors: Thomas Emma G. , Higgins Cathleen , Westgate Marie‐Noel , Lin Angela E. , Anderka Marlene , Holmes Lewis B. 
Published: August 2017

BackgroundMalformations surveillance programs among newborn infants are used to determine the prevalence of congenital anomalies. A comparison in the same group of infants between the malformations detected at birth and those detected at 1 year of age will identify errors in the surveillance process and, also, the abnormalities more likely not to be detected at birth, but later in the first year of life.MethodsThe malformations identified at birth by Brigham and Women's Hospital (BWH) in the years 2000 and 2005 have been compared with the abnormalities detected in the same infants up to age 1 year by the Massachusetts Birth Defects Monitoring Program.ResultsThe Massachusetts Birth Defects Monitoring Program identified 557 malformed infants in 2000 and 415 in 2005. Of these, 34 (3.5%) of the malformed infants were missed at birth by BWH Surveillance Program. An additional 22 (2.3%) malformed infants had delayed detection, as they were identified later in the first year. The reasons were the fact that: (1) the Surveillance staff reviewed the physicians’ recorded findings only on the first day of life; (2) failure of the examining pediatrician to record the presence of a malformation in her/his notes. The most common abnormalities with delayed detection were mild heart defects, such as atrial septal defects.ConclusionThese findings emphasize the importance in a newborn malformations surveillance program of continued follow up in the first days of life, especially in small, premature infants. Birth Defects Research 110:142–147, 2018. © 2017 Wiley Periodicals, Inc.
Chaetochromones A – C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006
Authors: Ju Zhi‐Ran , Lin Xiu‐Ping , Li Minke , Wang Ying , Tian Yong‐Qi , Wang Jun‐Feng , Liu Juan , Tu Zhengchao , Xu Shi‐Hai , Liu Yonghong 
Published: August 2017

Three new polyketides, chaetochromones A – C (1 – 3), together with a chromone (4), were isolated from the ethyl acetate extract of mangrove‐derived fungus Phomopsis sp. SCSIO 41006. Their structures were elucidated by means of spectroscopic techniques (UV, IR, MS, 1D‐ and 2D‐NMR). The absolute configurations of the new compounds were established by CD data.
Extending the Scope of GTFR Glucosylation Reactions with Tosylated Substrates for Rare Sugars Synthesis
Authors: Görl Julian , Possiel Christian , Sotriffer Christoph , Seibel Jürgen 
Published: August 2017

AbstractFunctionalized rare sugars were synthesized with 2‐, 3‐, and 6‐tosylated glucose derivatives as acceptor substrates by transglucosylation with sucrose and the glucansucrase GTFR from Streptococcus oralis. The 2‐ and 3‐tosylated glucose derivatives yielded the corresponding 1,6‐linked disaccharides (isomaltose analogues), whereas the 6‐tosylated glucose derivatives resulted in 1,3‐linked disaccharides (nigerose analogue) with high regioselectivity in up to 95 % yield. Docking studies provided insight into the binding mode of the acceptors and suggested two different orientations that were responsible for the change in regioselectivity.
Robotic technology in interventional cardiology: Current status and future perspectives
Authors: Mahmud Ehtisham , Pourdjabbar Ali , Ang Lawrence , Behnamfar Omid , Patel Mitul P. , Reeves Ryan R. 
Published: August 2017

AbstractRobotic technology has been utilized in cardiovascular medicine for over a decade, and over that period, its use has been expanded to percutaneous coronary and peripheral vascular interventions. The safety and feasibility of robotically assisted percutaneous cardiovascular interventions has been demonstrated in studies including simple to complex coronary lesions, and both iliac and femoropopliteal lesions. These reports have shown that robotically assisted PCI significantly reduces operator exposure to harmful ionizing radiation without a detrimental effect on procedural success or clinical efficacy. Additionally, the use of robotics has the intuitive benefit of alleviating the risk of orthopedic injuries faced by interventional operators. In addition to the interventional operator benefits, robotically assisted intervention has the potential for patient level benefit by allowing more accurate lesion length measurement, precise stent placement, and lower patient radiation exposure. However, further investigation is required to fully elucidate these potential benefits.
Utility of the guideliner catheter for percutaneous coronary interventions in patients with prior transcatheter aortic valve replacement
Authors: Bharadwaj Aditya S. , Bhatheja Samit , Sharma Samin K. , Kini Annapoorna S. 
Published: August 2017

AbstractThe safety and utility of GuideLiner catheters in complex percutaneous coronary interventions (PCI) has been well established. Patients with prior trans‐catheter aortic valve replacement especially with CoreValve, who present for PCI, pose a unique set of challenges. Not only does the operator often encounter difficulty with selective engagement of coronary ostia through the struts of the CoreValve, but also the complex nature of the underlying CAD in this high‐risk population. We present a case series to illustrate the use of GuideLiner catheter as an adjunctive tool for PCI in this patient population.
Designing an O2‐Insensitive Glucose Oxidase for Improved Electrochemical Applications
Authors: Tremey Emilie , Stines‐Chaumeil Claire , Gounel Sébastien , Mano Nicolas 
Published: August 2017

AbstractThe O2 reactivity of flavoproteins and particularly, glucose oxidase, is a limitation for numerous biotechnological applications, and this has been the subject of intense research. In the present study, we performed site‐directed mutations on Val464 of GOx from Penicilium amagasakiense and combined steady‐state, rapid kinetics and electrochemistry to investigate the effect of such mutations on the O2 reactivity. We propose that replacing the non‐polar Valine with a polar Serine permits to decrease the diffusion/stabilization of O2 near the active redox center without altering the oxidation of glucose. When incorporated in osmium hydrogels, the resulting electrodes were insensitive to O2 in the 0.5–60 mM glucose concentration range and were 4.7 times more stable under continuous operation than similar electrodes made with the native GOx. To the best of our knowledge, this is the first example in which O2 sensitivity in GOx can be significantly decrease without altering the electrochemical efficiency for glucose oxidation.
A Highly Sensitive Bimodal Detection of Amine Vapours Based on Aggregation Induced Emission of 1,2‐Dihydroquinoxaline Derivatives
Authors: Alam Parvej , Leung Nelson L. C. , Su Huifang , Qiu Zijie , Kwok Ryan T. K. , Lam Jacky W. Y. , Tang Ben Zhong 
Published: August 2017

AbstractThe detection of food spoilage is a major concern in food safety as large amounts of food are transported globally. Direct analysis of food samples is often time‐consuming and requires expensive analytical instrumentation. A much simpler and more cost‐effective method for monitoring food fermentation is to detect biogenic amines generated as a by‐product during food decomposition. In this work, a series of 1,2‐dihydroquinoxaline derivatives (DQs) with aggregation‐induced emission (AIE) characteristics were synthesised and their protonated forms, that is, H+DQs, can be utilised for the sensitive detection of biogenic amines. For example, upon exposure to amine vapours, deprotonation occurs that converts the red‐coloured, non‐emissive H+DQ2 back to its yellow‐coloured, fluorescent parent form. The bimodal absorption and emission changes endow the system with high sensitivity, capable of detecting ammonia vapour at a concentration of as low as 690 ppb. Taking advantage of this, H+DQ2 was successfully applied for the detection of food spoilage and was established as a robust and cost effective technique to monitor food safety.
Organocatalytic Highly Regio‐ and Enantioselective Umpolung Michael Addition Reaction of α‐Imino Esters
Authors: Yoshida Yasushi , Mino Takashi , Sakamoto Masami 
Published: August 2017

AbstractThe catalytic asymmetric umpolung reaction of ketimines is of great importance, because it can easily provide chiral amines bearing a tetrasubstituted carbon atom on its asymmetric center. Because amino acids with a tetrasubstituted carbon center are useful due to their wide applicability as pharmaceuticals and chiral building blocks, their enantioselective synthesis has great significance in organic synthesis. Herein, we demonstrate a metal‐free novel phase‐transfer‐catalyzed highly regio‐ and enantioselective umpolung Michael reaction of α‐imino esters, which provides amino acid derivatives in high yields with up to 98 % ee. The products are successfully converted into chiral amino acid derivative and δ‐lactone with high enantiopurity.
From an Easily Accessible Pentacarbonylcobalt(I) Salt to Piano‐Stool Cations [(arene)Co(CO)2]+
Authors: Meier Stefan C. , Holz Albina , Schmidt Alexei , Kratzert Daniel , Himmel Daniel , Krossing Ingo 
Published: August 2017

AbstractThe facile synthesis of a pentacarbonyl cobalt(I) salt without the need for a superacid as solvent is presented. This salt, [Co(CO)5]+[Al(ORF)4]− {RF=C(CF3)3}, readily accessible on a multigram scale, undergoes substitution reactions with arenes yielding the hitherto unknown class of two‐legged cobalt piano‐stool complexes [(arene)Co(CO)2]+ with four different arene ligands. Such a substitution chemistry would have been impossible in superacid solution, as the arenes used would have been oxidized and/or protonated. Thus, the general approach described herein may have a wide synthetic use. Additionally, the thermochemistry of the piano‐stool complexes is shown to be not easy to describe computationally and most of the established DFT methods overestimate the reaction energies. Only CCSD(T) calculations close to the basis set limit gave energies fully agreeing with the experiment.
Indole‐ and Pyrrole‐BX: Bench‐Stable Hypervalent Iodine Reagents for Heterocycle Umpolung
Authors: Caramenti Paola , Nicolai Stefano , Waser Jerome 
Published: August 2017

AbstractThe one‐step synthesis of the bench‐stable hypervalent iodine reagents IndoleBX and PyrroleBX using mild Lewis acid catalyzed conditions is reported. The new reagents are stable up to 150 °C and were applied in the C−H arylation of unactivated arenes using either rhodium or ruthenium catalysts. A broad range of heterocyclic systems of high interest for synthetic and medicinal chemistry was accessed in high yields. The developed C−H functionalization could not be achieved using reported reagents or methods, highlighting the unique reactivity of Indole‐ and Pyrrole‐BX.
Red color in flags: A signal for competition
Authors: Zhang Tengxiao , Feng Shiyu , Han Buxin , Sun Si 
Published: August 2017

AbstractThe color‐in‐context theory and ecological valence theory suggest that color preference depends on the context and ecological object that define the psychological meanings of colors. The present study was conducted to identify the preference for the color red in national flags across the world. We explored 192 national flags across the world and found that red was the most frequently used color. Through a systemic examination of symbolic meanings behind use of the color red in flags, it was also found that the color red was often attached with an aggressive connotation. In contrast, the flags of the selected international collaborative organizations did not appear to prefer red. These results support the hypothesis of “red flag preference” in real‐world competitive contexts. Limitations and future research directions are also discussed.
A Hydrogel/Carbon‐Nanotube Needle‐Free Device for Electrostimulated Skin Drug Delivery
Authors: Guillet Jean‐François , Flahaut Emmanuel , Golzio Muriel 
Published: August 2017

AbstractThe permeability of skin allows passive diffusion across the epidermis to reach blood vessels but this is possible only for small molecules such as nicotine. In order to achieve transdermal delivery of large molecules such as insulin or plasmid DNA, permeability of the skin and mainly the permeability of the stratum corneum skin layer has to be increased. Moreover, alternative routes that avoid the use of needles will improve the quality of life of patients. A method known as electropermeabilisation has been shown to increase skin permeability. Herein, we report the fabrication of an innovative hydrogel made of a nanocomposite material. This nanocomposite device aims to permeabilise the skin and deliver drug molecules at the same time. It includes a biocompatible polymer matrix (hydrogel) and double‐walled carbon nanotubes (DWCNTs) in order to bring electrical conductivity and improve mechanical properties. Carbon nanotubes and especially DWCNTs are ideal candidates, combining high electrical conductivity with a very high specific surface area together with a good biocompatibility when included into a material. The preparation and characterization of the nanocomposite hydrogel as well as first results of electrostimulated transdermal delivery using an ex vivo mouse skin model are presented.
Validation of the modified 4‐tiered categorization system through comparison with the 5‐tiered categorization system of the 2015 American Thyroid Association guidelines for classifying small thyroid nodules on ultrasound
Authors: Lee Ji Hye , Han Kyunghwa , Kim Eun‐Kyung , Moon Hee Jung , Yoon Jung Hyun , Park Vivian Y. , Kwak Jin Young 
Published: August 2017

AbstractBackgroundThe purpose of this study was to validate the modified 4‐tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines.MethodsFrom January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines.ResultsOn univariate analysis, there was no difference of malignancy risk between low suspicion and very low suspicion nodules (P = .584). Therefore, we suggested a modified 4‐tiered categorization, which combines very low suspicion and low suspicion nodules into the “revised low suspicion” category. Specificity, positive predictive value (PPV) and accuracy were higher with the modified 4‐tiered categorization system (P < .001 for all).ConclusionThe modified 4‐tiered categorization system allows more efficient management with better diagnostic performance than the 2015 ATA categorization system in small thyroid nodules.
Bidirectional stream–groundwater flow in response to ephemeral and intermittent streamflow and groundwater seasonality
Authors: Zimmer Margaret A. , McGlynn Brian L. 
Published: August 2017

AbstractIt is often assumed that the net groundwater flow direction is towards the channel in headwater streams in humid climates, with magnitudes dependent on flow state. However, studies that characterize stream–groundwater interactions in ephemeral and intermittent streams in humid landscapes remain sparse. Here, we examined seasonally driven stream–groundwater interactions in response to temporary streamflow on the basis of field observations of streamflow and groundwater on an adjacent hillslope. The direction of hydraulic head gradients between the stream and groundwater shifted seasonally. The stream gained water (head gradients were towards the stream) when storage state was high. During this period, streamflow was persistent. The stream lost water to the groundwater system (head gradients were away from the stream) when storage state was low. During this period, streamflow only occurred in response to precipitation events, and head gradients remained predominantly away from the stream during events. This suggested that mechanisms other than deep groundwater contributions produced run‐off when storage was low, such as surface and perched subsurface flowpaths above the water table. Analysis of the annual water balance for the study period showed that the residual between precipitation inputs and streamflow and evapotranspiration outputs, which were attributed to the loss of water to the deeper, regional groundwater system, was similar in magnitude to streamflow. This, coupled with results that showed bidirectionality in stream–groundwater head gradients, indicated that headwaters composed of temporary (e.g., ephemeral and intermittent) streams can be important focal areas for regional groundwater recharge, and both contribute to and receive water, solutes, and materials from the groundwater system.
Retracted: Effects of gene knockdown of CNP on ventricular remodeling after myocardial ischemia‐reperfusion injury through NPRB/Cgmp signaling pathway in rats
Authors: Wu Lian‐He , Zhang Qi , Zhang Shen , Meng Lu‐Yu , Wang Yan‐Chi , Sheng Cun‐Jian 
Published: August 2017

AbstractThis study aimed to explore effects of CNP on ventricular remodeling following myocardial ischemia‐reperfusion (I/R) injury through the NPRB/cGMP signaling pathway. Rat cardiomyocytes were assigned into: control, I/R, I/R + CNP, and I/R + 8‐Br‐cGMP groups. ELISA, qRT‐PCR, and Western blotting were used to detect cGMP content and expression, respectively. After model establishment of I/R rats, normal control, CNP−/− control, I/R, and CNP−/− groups were set. Indexes of heart were detected using echocardiography and hemodynamics. ELISA was used to measure serum CNP, cGMP, LDH, cTn I, CK‐MB, TNF‐α, and IL‐6 levels. Myocardial infarct was identified by TTC staining, and apoptosis conditions by TUNEL staining. QRT‐PCR and Western blotting were adopted to detect expressions of CNP, NPRB, cGMP, and apoptosis‐related genes. Compared with control group, cGMP contents and expression in the I/R, I/R + CNP and I/R + 8‐Br‐cGMP groups were decreased. Levels of LVEDV, LVESV, LVDS, LVDD, IVSD, LVM, LVEDP, and LVSP were higher in the I/R, CNP−/− control, and CNP−/−groups than normal control group while LVEF, SV, CO, and ±dp/dtmax were lower. Compared with the normal control group, LDH, cTn I, CK‐MB, TNF‐α, and IL‐6 were higher in the I/R, CNP−/− control and CNP−/− groups; pathological changes and myocardial infarction were observed in the I/R, CNP−/− control, and CNP−/− groups; expressions of apoptosis‐related genes in those groups were higher; while CNP, NPRB, cGMP, and Bcl‐2 expressions were decreased. We came to the conclusion that gene knockdown of CNP blocks the NPRB/cGMP signaling pathway, thereby aggravating myocardial I/R injury and causing ventricular remodeling in rats.
Implications of potential evapotranspiration methods for streamflow estimations under changing climatic conditions
Authors: Seong Chounghyun , Sridhar Venkataramana , Billah Mirza M. 
Published: August 2017

ABSTRACTSeveral potential evapotranspiration (PET) estimation methods are commonly used to quantify water and energy budgets. As each PET method can differ, their effects on projected streamflows under changing climatic conditions are critical to quantify the sensitivities of these methods. We used the Coupled Model Intercomparison Project (CMIP5) climate dataset and Hydrological Simulation Program – FORTRAN (HSPF) model to compare the following five PET methods [Hargreaves (HG), Hamon (HM), Thornthwaite (TW), Priestley–Taylor (PT) and Penman–Monteith (PM)] for the Susquehanna River Basin in the northeastern United States. As PET is used as an input, various configurations of HSPF driven by these five PET estimates were used to calibrate HSPF with observed streamflow data from 41 gaging stations. We also used nine global climate model inputs to derive five PET estimates, which were subsequently used as inputs to compute streamflow projections for 2020–2099. An increase in precipitation from 6.2 to 7.2% and an increase in temperature from 1.8 to 2.7 °C were projected, while changes in PET and actual evapotranspiration (AET) were found to substantially differ among the PET methods. The HM method shows an increase in AET of between 14 and 24%, while the other methods show an increase of between 7 and 12%. It is concluded that streamflow projections are sensitive to the selection of the PET methods in the HSPF model; a decrease of up to 5.5% and increase of up to 3.6% are projected for PET levels estimated by using the HM and HG methods, respectively; and both HM and TW are found to be suitable for simple seasonal water balance analyses conducted at regional scales.