bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint
Authors: Green Abby M. , Budagyan Konstantin , Hayer Katharina E. , Reed Morgann A. , Savani Milan R. , Wertheim Gerald B. , Weitzman Matthew D. 
Published: June 2017

Abstract
Mutational signatures in cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeutic vulnerability. Elevated APOBEC3B expression has been detected in solid tumors, but expression of APOBEC3A (A3A) in cancer has not been described to date. Here, we report that A3A is highly expressed in subsets of pediatric and adult acute myelogenous leukemia (AML). We modeled A3A expression in the THP1 AML cell line by introducing an inducible A3A gene. A3A expression caused ATR-dependent phosphorylation of Chk1 and cell-cycle arrest, consistent with replication checkpoint activation. Further, replication checkpoint blockade via small-molecule inhibition of ATR kinase in cells expressing A3A led to apoptosis and cell death. Although DNA damage checkpoints are broadly activated in response to A3A activity, synthetic lethality was specific to ATR signaling via Chk1 and did not occur with ATM inhibition. Our findings identify elevation of A3A expression in AML cells, enabling apoptotic sensitivity to inhibitors of the DNA replication checkpoint and suggesting it as a candidate biomarker for ATR inhibitor therapy. Cancer Res; 77(17); 4579–88. ©2017 AACR.
Verbal working memory-related functional connectivity alterations in boys with attention-deficit/hyperactivity disorder and the effects of methylphenidate
Authors: Wu Zhao-Min , Bralten Janita , An Li , Cao Qing-Jiu , Cao Xiao-Hua , Sun Li , Liu Lu , Yang Li , Mennes Maarten , Zang Yu-Feng , Franke Barbara , Hoogman Martine , Wang Yu-Feng 
Published: June 2017

Objective: Few studies have investigated verbal working memory-related functional connectivity patterns in participants with attention-deficit/hyperactivity disorder (ADHD). Thus, we aimed to compare working memory-related functional connectivity patterns in healthy children and those with ADHD, and study effects of methylphenidate (MPH). Method: Twenty-two boys with ADHD were scanned twice, under either MPH (single dose, 10 mg) or placebo, in a randomised, cross-over, counterbalanced placebo-controlled design. Thirty healthy boys were scanned once. We used fMRI during a numerical n-back task to examine functional connectivity patterns in case-control and MPH-placebo comparisons, using independent component analysis. Results: There was no significant difference in behavioural performance between children with ADHD, treated with MPH or placebo, and healthy controls. Compared with controls, participants with ADHD under placebo showed increased functional connectivity within fronto-parietal and auditory networks, and decreased functional connectivity within the executive control network. MPH normalized the altered functional connectivity pattern and significantly enhanced functional connectivity within the executive control network, though in non-overlapping areas. Conclusion: Our study contributes to the identification of the neural substrates of working memory. Single dose of MPH normalized the altered brain functional connectivity network, but had no enhancing effect on (non-impaired) behavioural performance.
CSF and clinical data are useful in differentiating CNS inflammatory demyelinating disease from CNS lymphoma
Authors: Ikeguchi Ryotaro , Shimizu Yuko , Shimizu Satoru , Kitagawa Kazuo 
Published: June 2017

Background: It is often difficult to diagnose central nervous system (CNS) inflammatory demyelinating diseases (IDDs) because they are similar to CNS lymphoma and glioma. Objective: To evaluate whether cerebrospinal fluid (CSF) analysis can differentiate CNS IDDs from CNS lymphoma and glioma. Methods: We measured CSF cell counts; concentrations of proteins, glucose, interleukin (IL)-6, IL-10, soluble IL-2 receptor (sIL-2R), and myelin basic protein; and IgG index in patients with multiple sclerosis (MS, n = 64), neuromyelitis optica spectrum disorder (NMOSD, n = 35), tumefactive demyelinating lesion (TDL, n = 17), CNS lymphoma ( n = 12), or glioma ( n = 10). We detected diagnostic markers using logistic regression and receiver operating characteristic (ROC) analyses. Results: Median CSF IL-10 and sIL-2R levels were higher in CNS lymphoma patients than in MS, NMOSD, or TDL patients. Logistic regression revealed that CSF sIL-2R levels predicted CNS lymphoma. In the ROC analysis of CSF sIL-2R levels, the area under the curve was 0.867, and the sensitivity and specificity were 83.3% and 90.0%, respectively. Conclusion: CSF sIL-2R levels can be used to differentiate CNS lymphoma from CNS IDDs. Further studies may identify other applications of CSF as a diagnostic biomarker.
Training and minimum wages: first evidence from the introduction of the minimum wage in Germany
Authors: Bellmann Lutz , Bossler Mario , Gerner Hans-Dieter , Hübler Olaf 
Published: June 2017

AbstractWe analyze the short-run impact of the introduction of the new statutory minimum wage in Germany on further training at the workplace level. Applying difference-in-difference methods to data from the IAB Establishment Panel, we do not find a reduction in the training incidence but a slight reduction in the intensity of training at treated establishments. Effect heterogeneities reveal that the negative impact is mostly driven by employer-financed training. On the worker level, we observe a reduction of training for medium- and high-skilled employees but no significant effects on the training of low-skilled employees.
Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe
Authors: Rashedi Alexandra S. , de Roo Saskia F. , Ataman Lauren M. , Edmonds Maxwell E. , Silva Adelino Amaral , Scarella Anibal , Horbaczewska Anna , Anazodo Antoinette , Arvas Ayse , Ramalho de Carvalho Bruno , Sartorio Cassio , Beerendonk Catharina C.M. , Diaz-Garcia Cesar , Suh Chang Suk , Melo Cláudia , Yding Andersen Claus , Motta Eduardo , Greenblatt Ellen M. , Van Moer Ellen , Zand Elnaz , Reis Fernando M. , Sánchez Flor , Terrado Guillermo , Rodrigues Jhenifer K. , de Meneses e Silva João Marcos , Smitz Johan , Medrano Jose , Lee Jung Ryeol , Winkler-Crepaz Katharina , Smith Kristin , Ferreira Melo e Silva Lígia Helena , Wildt Ludwig , Salama Mahmoud , del Mar Andrés María , Bourlon Maria T. , Vega Mario , Chehin Maurício Barbour , De Vos Michel , Khrouf Mohamed , Suzuki Nao , Azmy Osama , Fontoura Paula , Campos-Junior Paulo Henrique Almeida , Mallmann Peter , Azambuja Ricardo , Marinho Ricardo M. , Anderson Richard A. , Jach Robert , Antunes Roberto de A. , Mitchell Rod , Fathi Rouhollah , Adiga Satish Kumar , Takae Seido , Kim Seok Hyun , Romero Sergio , Chedid Grieco Silvana , Shaulov Talya , Furui Tatsuro , Almeida-Santos Teresa , Nelen Willianne , Jayasinghe Yasmin , Sugishita Yodo , Woodruff Teresa K. 
Published: June 2017

Purpose Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale. Methods Survey-based questionnaires were provided to 191 members of the Oncofertility Consortium Global Partners Network, a National Institutes of Health–funded organization. Responses were analyzed to measure trends and regional subtleties about patient oncofertility experiences and to analyze barriers to care at sites that provide oncofertility services. Results Sixty-three responses were received (response rate, 25%), and 40 were analyzed from oncofertility centers in 28 countries. Thirty of 40 survey results (75%) showed that formal referral processes and psychological care are provided to patients at the majority of sites. Fourteen of 23 respondents (61%) stated that some fertility preservation services are not offered because of cultural and legal barriers. The growth of oncofertility and its capacity to improve the lives of cancer survivors around the globe relies on concentrated efforts to increase awareness, promote collaboration, share best practices, and advocate for research funding. Conclusion This survey reveals global and regional successes and challenges and provides insight into what is needed to advance the field and make the discussion of fertility preservation and endocrine health a standard component of the cancer treatment plan. As the field of oncofertility continues to develop around the globe, regular assessment of both international and regional barriers to quality care must continue to guide process improvements.
Modeling and Analysis of Solar Photovoltaic Assisted Electrolyzer-Polymer Electrolyte Membrane Fuel Cell For Running a Hospital in Remote Area in Kolkata, India
Authors: Talukdar Kamaljyoti 
Published: June 2017

The present work consists of the modeling and analysis of solar photovoltaic panels integrated with electrolyzer bank and Polymer Electrolyte Membrane (PEM) fuel cell stacks for running different appliances of a hospital located in Kolkata for different climatic conditions. Electric power is generated by an array of solar photovoltaic modules. Excess energy after meeting the requirements of the hospital during peak sunshine hours is supplied to an electrolyzer bank to generate hydrogen gas, which is consumed by the PEM fuel cell stack to support the power requirement during the energy deficit hours. The study reveals that 875 solar photovoltaic modules in parallel each having 2 modules in series of Central Electronics Limited Make PM 150 with a 178.537 kW electrolyzer and 27 PEM fuel cell stacks, each of 382.372 W, can support the energy requirement of a 200 lights (100 W each), 4 pumps (2 kW each), 120 fans(65 W each) and 5 refrigerators (2 kW each)system operated for 16 hours, 2 hours,15 hours and 24 hours respectively. 123 solar photovoltaic modules in parallel each having 2 modules in series of Central Electronics Limited Make PM 150 is needed to run the gas compressor for storing hydrogen in the cylinder during sunshine hours. Article History: Received Feb 5th 2017; Received in revised form June 2nd 2017; Accepted June 28th 2017; Available onlineHow to Cite This Article: Talukdar, K. (2017). Modeling and Analysis of Solar Photovoltaic Assisted Electrolyzer-Polymer Electrolyte Membrane Fuel Cell For Running a Hospital in Remote Area in Kolkata,India. International Journal of Renewable Energy Development, 6(2), 181-191.https://dx.doi.org/10.14710/ijred.6.2.181-191
Muscle Strength Is Protective Against Osteoporosis in an Ethnically Diverse Sample of Adults
Authors: McGrath Ryan P. , Kraemer William J. , Vincent Brenda M. , Hall Orman T. , Peterson Mark D. 
Published: June 2017

Abstract
McGrath, RP, Kraemer, WJ, Vincent, BM, Hall, OT, and Peterson, MD. Muscle strength is protective against osteoporosis in an ethnically diverse sample of adults. J Strength Cond Res 31(9): 2586–2589, 2017—The odds of developing osteoporosis may be affected by modifiable and nonmodifiable factors such as muscle strength and ethnicity. This study sought to (a) determine whether increased muscle strength was associated with decreased odds of osteoporosis and (b) identify whether the odds of osteoporosis differed by ethnicity. Data from the 2013 to 2014 National Health and Nutrition Examination Survey were analyzed. Muscle strength was measured with a hand-held dynamometer, and dual-energy x-ray absorptiometry was used to assess femoral neck bone mineral density. A T-score of ≤2.5 was used to define osteoporosis. Separate covariate-adjusted logistic regression models were performed on each sex to determine the association between muscle strength and osteoporosis. Odds ratios (ORs) were also generated to identify if the association between muscle strength and osteoporosis differed by ethnicity using non-Hispanic blacks as the reference group. There were 2,861 participants included. Muscle strength was shown to be protective against osteoporosis for men (OR: 0.94; 95% confidence interval [CI]: 0.94–0.94) and women (OR: 0.90; CI: 0.90–0.90). Although ORs varied across ethnicities, non-Hispanic Asian men (OR: 6.62; CI: 6.51–6.72) and women (OR: 6.42; CI: 6.37–6.48) were at highest odds of osteoporosis. Increased muscle strength reduced the odds of osteoporosis among both men and women in a nationally representative, ethnically diverse sample of adults. Non-Hispanic Asians had the highest odds of developing osteoporosis. Irrespective of sex or ethnicity, increased muscle strength may help protect against the odds of developing osteoporosis.
Pitch Size and Game Surface in Different Small-Sided Games. Global Indicators, Activity Profile, and Acceleration of Female Soccer Players
Authors: López-Fernández Jorge , Gallardo Leonor , Fernández-Luna Álvaro , Villacañas Victor , García-Unanue Jorge , Sánchez-Sánchez Javier 
Published: June 2017

Abstract
López-Fernández, J, Gallardo, L, Fernández-Luna, Á, Villacañas, V, García-Unanue, J, and Sánchez-Sánchez, J. Pitch size and game surface in different small-sided games. Global indicators, activity profile, and acceleration of female soccer players. J Strength Cond Res 33(3): 831–838, 2019—The aim of this research was to evaluate the influence of game surface and pitch size on the movement profile in female soccer players during small-sided games (SSGs) of 4 v 4. Sixteen women played 3 different 4-a-side (400, 600, and 800 m2) on 3 surfaces (ground [GR], artificial turf [AT], and natural grass [NG]). Time-motion variables were assessed through GPS devices (Spi Pro X, GPSports, Australia). Ground had the worst outputs on most variables. NG achieved higher results than AT in terms of total distance (SSG 400 [+37.000 m; p = 0.006]; SSG 600 [+59.989 m; p < 0.001]; and SSG 800 [+42.284 m; p = 0.001]). However, the smaller SSG (400) had the lowest values on most variables. However, although the middle SSG (600) presented higher output than the bigger one (800) for body load (NG [+7.745 a.u.; p < 0.001]; AT [+8.207 a.u.; p < 0.001]; and GR [+5.879 a.u.; p < 0.001]), it had lower results for high-intensity distance (NG [−13.15 m; p = 0.025] and AT [−13.59 m; p = 0.026]). Despite women's performance being higher on AT than GR, the NG surface still showed the highest outcomes in the most intense SSG. Moreover, although the performance increases in bigger pitches, if the size is too large the outputs could be reduced.
Promouvoir l’accessibilité à l’aide de la loi: un appel à une réforme législative au Québec
Authors: Bénard Mélanie 
Published: June 2017

Cet article traite de l’évolution des lois à l’égard des personnes handicapées au Québec. Il démontre les lacunes importantes du cadre législatif actuel, illustrant ainsi la nécessité d’une réforme législative pour assurer le droit à l’égalité des personnes handicapées. En 1978, l’Assemblée nationale adopta la Loi assurant l’exercice des droits des personnes handicapées, loi fort avant-gardiste pour l’époque. Cette loi créa l’Office des personnes handicapées du Québec (l’OPHQ) et comprenait plusieurs dispositions visant l’amélioration de l’accessibilité des services et des lieux publiques. La loi de 1978 fut amendée en 2004 pour modifier les obligations du secteur public et pour redéfinir le rôle de l’OPHQ. Malgré ses amendements, la loi québécoise manque du mordant. Contrairement aux cadres législatifs dans d’autres juridictions, la loi québécoise s’applique seulement au secteur public et elle ne contient aucune mesure efficace de mise en œuvre. En conséquence, d’innombrables obstacles continuent à limiter l’inclusion et la participation sociale des personnes handicapées au Québec. This article traces the evolution of Quebec’s disability legislation. Pointing out important gaps in the current legal framework, it demonstrates the need for legislative reform to ensure the full inclusion of people with disabilities in Quebec society. In 1978, the National Assembly adopted the Act to secure handicapped persons in the exercise of their rights. This cutting-edge law contained several measures aimed at improving the accessibility of public services and spaces. It also created a government Disability Office, the Office des personnes handicapées du Québec (OPHQ). This law was amended in 2004 to redefine the role of the OPHQ and to modify the obligations of the public sector. Despite these amendments, Quebec’s disability legislation lacks teeth. Unlike laws in other jurisdictions, Quebec’s disability law only applies to the public sector and it lacks strong enforcement mechanisms. As a result, Quebecers with disabilities continue to face countless barriers in exercising their right to equality.
Пограничные зоны человеческого существования и их осознание человеком
Authors: Луков Валерий Андреевич 
Published: June 2017

<p>В статье рассматриваются те стороны человеческой жизни, которые им самим рассматриваются как пограничные в зависимости от эпохи и культурных кодов. Применяется тезаурусный подход, который рассматривается как субъектная организация знания о человеке и определяет пограничные зоны его существования как переход от одного состояния к другому.</p>
O projeto filosófico-educativo dos helenos
Authors: Santos José Gabriel Trindade 
Published: June 2017

Dedicado ao tema da educação na Grécia Antiga, o presente número de Filosofia e Educação concentra-se na análise e na descrição do processo conducente à formulação do problema social e cultural da Educação. Embora a difusão do letramento na Cultura grega obrigue o fulcro da questão a convergir na Atenas dos sécs. V-IV, a.C., a complexidade do processo educativo não poderá ser abarcada se a Educação não for inserida no horizonte da História da Grécia, nos períodos Arcaico e Clássico.
É possível confiar nas pesquisas eleitorais? Análise das intenções de votos nas eleições para governadores no Brasil em 2014
Authors: Kamradt João 
Published: June 2017

<p><strong>RESUMO</strong></p><p>Pesquisas de opinião sobre candidatos a cargos públicos são muito utilizadas em época de eleição. Os dados servem para mostrar qual é a fotografia do momento, quem está na frente e apontar tendências de queda ou crescimento para os pesquisados. E aí reside um problema. Mesmo com tanta importância, são escassos os estudos que medem o grau de confiabilidade das pesquisas eleitorais no Brasil. É disto que este artigo trata. Após fazer uma breve revisão da literatura sobre as pesquisas eleitorais e a opinião pública, o trabalho apresenta um balanço feito com 77 pesquisas de 23 institutos diferentes nos 27 estados brasileiros antes da realização do primeiro e do segundo turno das eleições de 2014 no Brasil. Ao todo, foram analisados 302 candidatos. Os resultados indicaram que 32% dos candidatos pesquisados tiveram previsões que não se realizaram, sendo que a maioria dos erros se deu no primeiro turno. Quase 15% das pesquisas apresentaram candidatos trocando de posições entre a previsão e o resultado nas urnas. Entre as razões para tantos equívocos estão a utilização da margem de erro, a coleta de dados feita em um período distante do pleito e a quantidade de eleitores indecisos até a proximidade da votação.</p><p> </p><p><strong>ABSTRACT</strong> </p>Opinion polls on candidates for public offices are widely used at election time. The data are used to show which is the picture of the moment, which candidates are in the lead and pointing downward trends or growth for the respondents. And therein lies a problem. Even with such importance, there are few studies that measure the degree of reliability of polls in Brazil. This is what this article is about. After making a brief review of the literature on polls and public opinion, the work presents a debriefing with 77 research institutes in 23 different 27 states prior to the first and second round of the 2014 elections in Brazil. In all, 302 candidates were analyzed. The results indicated that 32% of the candidates surveyed had forecast that did not occur, and that most errors occurred in the first round. Almost 15% of the research presented candidates swapping positions between the forecast and the result at the polls. Among the reasons for so many misconceptions are using the margin of error, data collection made in a distant period of the election and the number of undecided voters to the closeness of the vote.
Determination Of Some Biological Characteristics Of Poppy Root Weevils (Ethelcus denticulatus (Schrank) (Coleoptera: Curculionidae) For Struggle
Authors: İSLAMOĞLU Mahmut 
Published: June 2017

With this project, it is aimed to determine the time of the struggle with the poppy root weevils (Ethelcus denticulatus Schrank) (Coleoptera: Curculionidae), which is the most important pest of poppy fields (Papaver somniferum L.) (Rhoedales; Papaveraceae). According to the findings, it has been determined that after the second week of March in the Uşak province, poppy root weevils start to emerge from the soil and adults may be found until the first week of July. The most important factor in the emergence of the pests from soil to surface is temperature. In the second week of March in which effective temperature reached to 14 ºC, the poppy root weevils started to emerge to the soil surface in 2014 and 2015. Peak of the poppy root weevils was determined to be in the second week of April. The sum of effective temperatures at this date was determined to be 70.6 ºC in 2014 and 90.4 ºC in 2015. After the poppy root weevil’s emergence reached the peak, the first larvae began to appear about 10 days later. According to this, when the insect populations are the highest and the sum of effective temperatures is 70 - 90 ºC, it is suggested to make chemical struggle.