bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration
Authors: Koriem Khaled M.M. , Arbid Mahmoud S.S. 
Published: September 2024

Abstract

Objectives
Favism is a metabolic disease while pracaxi oil is a strong antioxidant agent. This study evaluates anti-infertility activity and assists normal male fertilization of pracaxi oil in favism-induced male rats.

Methods
A total of 36 male albino rats of six equal sets were each with 6 rats; Control, Pracaxi oil (1 mL), and Pracaxi oil (2 mL), Favism-induced male rats-, Pracaxi oil (1 mL) + Favism-induced male rats, and Pracaxi oil (2 mL) + Favism-induced male rats groups. Blood parameters, liver function, serum male hormones were determined. Glucose-6-phosphate dehydrogenase, 3β-hydroxysteroid dehydrogenase, total protein, and cholesterol in testis were estimated. Sodium/potassium-ATPase and antioxidants in the hypothalamus, testis, and sperm were assessed. Sperm count, motility, and abnormality, and sperm monoclonal proliferating antibody Ki-67 were evaluated.

Results
Favism decreased blood parameters, liver function, superoxide dismutase, glutathione, serum testosterone and dehydroepiandrosterone sulfate, sperm count and motility, sodium/potassium-ATPase activity while increased malondialdehyde, serum follicle stimulating hormone, sex hormone binding globulin, and luteinizing hormone, glucose-6-phosphatedehydrogenase, 3β-hydroxysteroid dehydrogenase, cholesterol, total protein, sperm abnormality, the percentage of spermatogonia, 1st spermatocyte, 2nd spermatocyte, and spermatid in the testis. Furthermore, two doses of pracaxi oil to favism-induced male rats back all of aforementioned parameters to be close control values where a higher dose of pracaxi oil had an efficient impact than a lower dose.

Conclusions
Pracaxi oil protects the hypothalamic-pituitary-gonad axis, and preserves sperm quality in favism-induced male rats.
Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
Authors: Braun Andreas Albert , Atiya Monika , Göhner Katja , Hortobagyi Tibor , Burkhardt Tobias , Schreiner Bettina 
Published: September 2024

Abstract

Introduction
Statin use can lead to various muscle-related issues, including benign creatine kinase (CK) elevations, myalgias, toxic myopathies, rhabdomyolysis, and immune-mediated necrotizing myositis (IMNM), which primarily affects older males. IMNM presents with proximal muscle weakness, elevated CK levels, and specific antibodies.

Case presentation
We describe a 72-year-old patient with muscle weakness persisting for over 3 years after statin therapy. Initially suspected to have a genetic disorder, further testing revealed elevated anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibodies, indicating immune-mediated myopathy. Despite the absence of inflammatory changes on biopsy, the patient responded positively to immune therapy.

Conclusion
This case highlights challenges in diagnosing immune-mediated myopathy, especially in older patients with atypical presentations. Testing for HMGCR antibodies can aid in diagnosis, particularly when inflammatory markers are absent. Awareness of red flags, such as delayed symptom onset and response to prednisone, is crucial for accurate diagnosis and management.
Highly uniform silicon nanopatterning with deep-ultraviolet femtosecond pulses
Authors: Granados Eduardo , Martinez-Calderon Miguel , Groussin Baptiste , Colombier Jean Philippe , Santiago Ibon 
Published: September 2024

Abstract
The prospect of employing nanophotonic methods for controlling photon–electron interactions has ignited substantial interest within the particle accelerator community. Silicon-based integrated dielectric laser acceleration (DLA) has emerged as a viable option by leveraging localized photonic effects to emit, accelerate, and measure electron bunches using exclusively light. Here, using highly regular nanopatterning over large areas while preserving the crystalline structure of silicon is imperative to enhance the efficiency and yield of photon-electron effects. While several established fabrication techniques may be used to produce the required silicon nanostructures, alternative techniques are beneficial to enhance scalability, simplicity and cost-efficiency. In this study, we demonstrate the nano-synthesis of silicon structures over arbitrarily large areas utilizing exclusively deep ultraviolet (DUV) ultrafast laser excitation. This approach delivers highly concentrated electromagnetic energy to the material, thus producing nanostructures with features well beyond the diffraction limit. At the core of our demonstration is the production of silicon laser-induced surface structures with an exceptionally high aspect-ratio -reaching a height of more than 100 nm- for a nanostructure periodicity of 250 nm. This result is attained by exploiting a positive feedback effect on the locally enhanced laser electric field as the surface morphology dynamically emerges, in combination with the material properties at DUV wavelengths. We also observe strong nanopattern hybridization yielding intricate 2D structural features as the onset of amorphization takes place at high laser pulse fluence. This technique offers a simple, yet efficient and attractive approach to produce highly uniform and high aspect ratio silicon nanostructures in the 200–300 nm range.
Optical Zitterbewegung effect in arrays of helical waveguides
Authors: Zhan Kaiyun , Chen Qixuan , Zhang Qian , Zhao Tingjun , Qin Hanqiang , He Haolong , Yao Guangting 
Published: September 2024

Abstract
Owing to its topological properties and band collapse, Floquet helical photonic lattices have gained increasing attention as a purely classical setting to realize the optical analogues of a wide variety of quantum phenomena. We demonstrate both theoretically and numerically that light propagation in an appropriately designed helical superlattice can exhibit spatial photonic Zitterbewegung effect, i.e., a quiver spatial oscillatory motion of the beam center of mass around its mean trajectory, in both one- and two-dimensional cases. The lattice spacing determines the effective coupling strength between adjacent helical waveguides, and further drastically not only affects the oscillation amplitude and frequency, but also invert their direction of drift when the effective coupling strength is tuned from positive to negative. Complete arrest and inversion of the drift direction of Zitterbewegung effect are reported.
Calling and Responding: An Ethical-Existential Framework for Conceptualising Interactions “in-between” Self and Other
Authors: Jons Lotta 
Published: September 2024

Abstract
In this article, the methodological meaning of listening will be explored as an ethical-existential heeding. Grounded in an understanding of listening as a matter of heeding, I present a framework founded on Martin Buber’s dialogical philosophy entitled Calling and Responding, in which human being’s relation to the world is conceptualised as a process of paying heed to a summons from the Other – followed by a responsible response to that summons – and in turn calling the Other. Such an understanding of the interactions in-between self and the Other is based on the premise that one has an auditory disposition when perceiving and dealing with the world. I elaborate the Buberian foundation of the concepts comprising the framework, clarify the method of philosophical conceptualisation, and present practical examples from the context of pedagogical relations.
MEN2 phenotype in a family with germline heterozygous rare RET K666N variant
Authors: La Greca A , Dawes D , Albuja-Cruz M , Raeburn C , Axell L , Ku L , Klein C , Marshall C , Fishbein L 
Published: September 2024

Summary
Multiple endocrine neoplasia type 2 (MEN2) is a hereditary cancer syndrome caused by germline-activating pathogenic variants in the RET proto-oncogene. MEN2A is the most common subtype, with a risk for medullary thyroid cancer (MTC), pheochromocytoma (PHEO), and primary hyperparathyroidism (PHPT), whereas MEN2B is less common and associated with MTC and PHEO along with mucosal neuromas. Little is known about the specific RET germline heterozygous variant K666N. This variant has been described in very few families, and in most cases, patients were diagnosed with a very indolent MTC as the only feature. There is one case of MTC and bilateral PHEO. The RET K666N variant is not stratified yet by the American Thyroid Association, and data are limited on pathogenicity; therefore, appropriate screening and treatment of asymptomatic RET K666N carriers are unclear. Here, we report a family with a heterozygous germline RET K666N variant. The proband was identified when she experienced cardiogenic shock and multi-organ failure after an elective hysterectomy and subsequently was found to have PHEO, with genetic testing revealing the RET K666N germline variant. Patient consent was obtained through IRB protocol COMIRB #15-0516.

Learning Points

The specific RET germline heterozygous variant K666N is rare and described in very few families, and in most cases, patients were diagnosed with a very indolent MTC as the only feature. Our proband is much younger and has PHEO, MTC, and PHPT.

The RET K666N germline variant appears to be a low penetrance variant for MEN2.
The RACE Act and Pediatric Trials of Adult Cancer Drugs
Authors: Liu Ian T. T. , Kesselheim Aaron S. 
Published: September 2024

BACKGROUND AND OBJECTIVES
Adult cancer drugs have historically been exempted from pediatric testing requirements. In 2017, Congress passed the Research to Accelerate Cures and Equity (RACE) for Children Act to expand mandatory pediatric testing to cancer drugs; the law took effect in 2020. With this study, we sought to evaluate how the pediatric testing of molecularly targeted adult cancer drugs changed after the RACE Act.

METHODS
In this retrospective cohort study, we used publicly available Food and Drug Administration data to compare pediatric post-approval requirements, trials, and trial characteristics, including timing, in adult cancer drugs before and after the RACE Act.

RESULTS
Between 2017 and 2024, the Food and Drug Administration approved 61 adult cancer drugs with molecular targets relevant to pediatric cancer; 40 were submitted before 2020, and 21 were submitted after 2020. The 40 pre-RACE Act drugs were associated with no pediatric post-approval requirements, whereas the 21 post-RACE Act drugs were associated with 15 pediatric post-approval testing requirements. Approximately two-thirds (26/40, 65%) of pre-RACE Act drugs and 57% (12/21) of post-RACE Act drugs were evaluated in pediatric trials. Among pre-RACE Act cancer drugs, pediatric trials were initiated a median of 0.04 years after approval (interquartile range: −3.3 to 1.9 years), whereas post-RACE Act trials were initiated a median of 2.8 years before approval (interquartile range: −4.3 to 0.3 years).

CONCLUSIONS
The RACE Act has been associated with greater numbers of pediatric post- approval testing requirements and the earlier initiation of pediatric trials, although early pediatric trial rates appear unchanged. Formalizing pediatric testing requirements may lead to the timely completion of pediatric studies to the benefit of pediatric patients with cancer.
Microstructure analysis of cement-biochar composites
Authors: Lorenzoni Renata , Cunningham Patrick , Fritsch Tobias , Schmidt Wolfram , Kruschwitz Sabine , Bruno Giovanni 
Published: September 2024

AbstractThe use of biochar as a concrete constituent has been proposed to reduce the massive carbon footprint of concrete. Due to the low density and complex porosity of biochar, microstructural analysis of Portland cement-biochar composites is challenging. This causes challenges to the improvement of the micro-scale understanding of biochar composite behavior. This work advances the microstructural understanding of Portland cement composites with 0, 5, and 25 volume percent (vol%) of cement replaced with wood biochar by applying common characterization techniques of mercury intrusion porosimetry (MIP), gas sorption, scanning electron microscopy, and isothermal heat flow calorimetry (HFC) in conjunction with 1H nuclear magnetic resonance (NMR) and micro-X-ray computed tomography (XCT) analysis techniques. The combination of these techniques allows a multi-scale investigation of the effect of biochar on the microstructure of cement paste. NMR and XCT techniques allow the observation and quantification of the pore space. HFC and MIP confirmed that biochar absorbs moisture and reduces the effective water-cement ratio. Gas sorption, MIP, and NMR shows that 5 vol% replacement does not significantly affect the gel and capillary pore structures. Results from XCT (supported by MIP and NMR) show that biochar can reduce the formation of larger pores. Importantly, XCT results suggest that biochar can act as a flaw in the microstructure which could explain reductions in the mechanical properties. Overall, the mechanical properties already analyzed in the literature are consistent with the microstructural changes observed, and these results highlight the need to carefully tailor the volume fraction of biochar to control its effect on the paste microstructure.
ЛИЧНОСТЬ АВТОРА В ЭПОХУ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА: УРОКИ ОБЩЕЙ ТЕОРИИ АВТОРСТВА
Authors: УЛЬБАШЕВ Алим Хусейнович 
Published: September 2024

Статья посвящена проблематике правосубъектности искусственного интеллекта (ИИ) и статусу автора в информационных правоотношениях. В частности, ставится вопрос о принципиальной возможности наделения ИИ самостоятельными правами и обязанностями. Для решения поставленной задачи анализируется общая теория авторства.
Правовой режим результатов интеллектуальной деятельности и их экономическая ценность предопределяются не только особенностями объекта прав, но и характеристиками лица, принимающего непосредственное участие в их создании. При этом авторами могут быть признаны лишь физические лица (граждане). Стало быть, охрана прав автора подлежит рассмотрению в более общем контексте защиты прав человека.
Аргументировано, что искусственный интеллект per se не является автором произведения. По общему правилу автором считается лицо, эксплуатирующее искусственный интеллект в своих интересах. Искусственный интеллект не может обладать личными неимущественными правами, носителем которых также может быть лишь физическое лицо (гражданин).
О необоснованности признания правосубъектности за искусственным интеллектом свидетельствует весь исторический опыт развития правовой мысли в России и за рубежом. Юрисдикции, основанные на римской правовой традиции, отводят человеку и его правам главенствующую роль в системе права. Уравнивание правового статуса людей и машин, программ и роботов привело бы к умалению прав и свобод граждан.
Таким образом, ИИ, несмотря на его важное значение в жизни современного общества, не образует самостоятельную правосубъектность. В экономическом смысле он является орудием труда, в юридическом — должен быть квалифицирован в качестве объекта прав.
Influence of human resources development on technical college teachers’ self-concept and productivity in Ogun State, Nigeria
Authors: Aderinto Idowu Dare , Mukaila Abiodun Yisa , Fadairo Olatunji Oriola 
Published: September 2024

The productivity of any establishment is heavily relied on the welfare of its workers which is a determinant to degree of their output. Hence this study examined the influence of human resources development on technical college teachers’ self-concept, and productivity in Ogun State. Descriptive survey research design was adopted for the study. The population for this study comprised all technical college teachers in Ogun State with sample size of 60 technical college teachers. Structured questionnaire was data collection. Cronbach Alpha reliability technique was used to establish the internal consistency of the instrument and a reliability coefficient of 0.85 was obtained. Data was analyzed with descriptive statistics of mean and standard deviation for answering research questions, while the hypothesis was tested using Correlation Matrix and linear regression. The findings revealed that there is significant influence of human resources development on technical college teachers’ self-concept (β =.748; p ˂ 0.05) and their productivity (β = .830; p ˂ 0.05). It was concluded that human resources development must be embraced to regularly update educators’ skills. Recommendation include that relevant human resources management programmes such as workshops, conferences, short-term programs among others should be introduced to improve self-concept and productivity of technical college teachers.
Implementasi Metode Waterfall Dalam Sistem Informasi Penggajian Berbasis Desktop Pada Cv. Pionir Mandiri Jaya Gresik
Authors: Prasetiya Panca , Dewa Weda Adistianaya 
Published: September 2024

This Payroll Information System is developed in response to the needs and requests of CV. Pionir Mandiri Jaya to improve the efficiency of the employee payroll process. One of the problems faced is the delay in delivering salary reports, caused by a manual system prone to input errors. This research addresses this issue by implementing a desktop-based information system using Java programming and MySQL as its database. The researchers employed the Waterfall System Development Life Cycle (SLDC) method to develop the system in this study. The processed data includes employee information, attendance recapitulation, and salary calculations. The output generated is a salary slip containing information about work allowances and deductions for each employee—the implementation of the CV. Pionir Mandiri Jaya Payroll Information System is expected to expedite the employee payroll recording process by improving time efficiency. We evaluated the effectiveness of this new system by comparing it with the previous conventional process, which has been proven to increase efficiency by up to 55 minutes per transaction. Therefore, evidence of the efficiency of this system can be identified through a comparison of payroll delay data before and after the implementation of the new system.
Sistem Informasi Penggajian ini dibuat sebagai respon terhadap kebutuhan dan permintaan dari CV. Pionir Mandiri Jaya dalam rangka meningkatkan efisiensi proses penggajian karyawan. Salah satu masalah yang dihadapi adalah keterlambatan dalam penyampaian laporan gaji, yang disebabkan oleh sistem manual yang rentan terhadap kesalahan. Penelitian ini bertujuan untuk mengatasi masalah tersebut dengan mengimplementasikan sistem informasi berbasis desktop menggunakan pemrograman Java dan MySQL sebagai basis datanya. Dalam penelitian ini menggunakan metode Waterfall System Development Life Cycle (SLDC) untuk mengembangkan sistem. Data yang diolah mencakup informasi pegawai, rekapitulasi kehadiran, dan perhitungan gaji. Output yang dihasilkan adalah slip gaji yang mencakup informasi tentang tunjangan kerja dan potongan gaji bagi setiap karyawan. Implementasi Sistem Informasi Gaji CV. Pionir Mandiri Jaya diharapkan dapat mempercepat proses pencatatan gaji karyawan dengan meningkatkan efisiensi waktu. Evaluasi terhadap efektivitas sistem baru ini dilakukan dengan membandingkan dengan proses konvensional sebelumnya, yang telah terbukti meningkatkan efisiensi dari keterlambatan 6 hari kerja proses penggajian menjadi 1 hari kerja. Oleh karena itu, efisiensi sistem informasi ini dapat diidentifikasi melalui perbandingan data keterlambatan penggajian sebelum dan setelah implementasi sistem baru.
Questionnaire based observational study of association of pruritus with intake of food items in common skin disorders
Authors: Tiwary Pankaj Kumar , Hussain Mobarak , Singh Anupama 
Published: September 2024

Pruritus is the commonest symptom of majority of dermatological diseases. Various chemicals in certain foods are known to trigger release of pruritogenic mediators causing pruritus. Also, there are myths about diet in the population that consumption of certain food items exacerbates their pruritus, which needs proper patient counseling.Questionnaire-based observational study of association of pruritus with intake of food items in common skin disorders. The duration of this cross-sectional study was 6 months in a tertiary care hospital in Patna. Cases with pruritic skin disorders were asked about their food habits and the association of any specific food item with exacerbation in itching by using a fixed set of questions. Among 306 patients, 147 patients complained of exacerbation in pruritus after eating certain food items (p-value- 0.02), out of which 69 had issues with single food item and 72 patients had association with multiple eatables. In specific food, it was observed that spicy vegetables like Brinjal, jackfruit, onion, and garlic were the most common culprits causing pruritus in 86 patients (p-value- 0.035), which was followed by fish which exacerbated pruritus in 45 patients (p-value- 0.055). When the skin is inflamed by any pathology, its threshold to flare is low and various food items may trigger a pruritic sensation. So, proper counseling of such food items will help to relieve the pruritus and hence better management of the underlying diseases.
A comparative study on therapeutic efficacy between methotrexate iontophoresis and topical methotrexate 1% gel in palmoplantar psoriasis
Authors: Vijayananth Jayakalyani , Venu Sridhar , Iyappan Nithya , Ramasamy Sindhuja 
Published: September 2024

Palmoplantar psoriasis is a disease which often leads to disfigurement and disability. It is resistant to conventional therapy where systematic therapy mostly with methotrexate is indicated. To overcome systemic toxicity of the drug, topical delivery methods has been tried recently with unsatisfactory results because of its poor penetration. Iontophoresis may help to increase its absorption and thereby efficacy. Our study included a total of 60 patients fulfilling the selection criteria. They were randomly divided into two groups, group A & group B; comprising 30 patients in each. The patients in Group A received topical methotrexate 1% gel twice daily treatment for 8 weeks on all days. The patients in Group B underwent methotrexate iontophoresis once in a week for 4 weeks followed by every two weeks. A total of six session of iontophoresis was done and both groups were followed up for another 3 months. Evaluation of therapeutic efficacy was done by assessing the lesions for erythema, scaling and fissuring during each visit and follow up period. Overall improvement in group A and group B were 82.4% and 95.3% respectively. Recurrence rates were nearly similar in both groups. There was highly statistical significant improvement and clearance rates with group B at the end of 8 weeks of therapy and after follow up period compared to group A (p value &#60; 0.01).
Assessment of efficacy of autologous platelet rich plasma in crow’s feet wrinkles
Authors: Gundappa Pavithra , Ramesh Heera , Somashekhar Sachin 
Published: September 2024

The aim of the study was to evaluate the efficacy of autologous platelet rich plasma in the treatment of crow’s feet wrinkles.In a study conducted for 6 months duration, 20 participants were treated with 2 sessions of PRP monthly once. Patients received 1 ml of PRP to each side of crow’s feet and infra orbital area. Study was evaluated by comparing pre and post treatment photographs, subjective satisfaction score, objective clinical assessment and side effects.A definitive improvement was found in most of the patients. Patient satisfaction score showed grade 3 improvement in 5%, grade 2 in 40%, grade 1 in 50% and no improvement in 5%. Objective clinical assessment showed grade 3 improvement in 5%, grade 2 in 60%, grade 1 in 35%. Good results were observed in objective clinical assessment (p value &#60;0.001) as well as patient satisfaction scoring without much side effects.The present study concludes that PRP therapy is cost effective and safe in treatment of crow’s feet wrinkles.