bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major Publications in the Critical Care Pharmacotherapy Literature: 2023
Authors: Murray Brian , Athale Janhavi , Balk Robert A. , Behal Michael L. , Brown Judah E. , Chanas Tyler , Dumitru Roxana , Gifford Dalton C. , Hohlfelder Benjamin , Jones Honey M. , Makic Mary Beth F. , Rausen Michelle S. , Sacco Alicia J. , Sines Benjamin J. , Gurnani Payal K. 
Published: October 2024

OBJECTIVES:
We aimed to summarize the most significant and impactful publications describing the pharmacotherapeutic care of critically ill patients in 2023.

DATA SOURCES:
PubMed/MEDLINE and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update.

STUDY SELECTION:
Randomized controlled trials and prospective studies of adult critically ill patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints published between January 1, 2023, and December 31, 2023, were eligible for inclusion in this article.

DATA EXTRACTION:
Articles from a systematic search and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update were included. An a priori defined three-round modified Delphi process was employed to achieve consensus on the most impactful publications based on the following considerations: 1) overall contribution to scientific knowledge and 2) novelty to the literature.

DATA SYNTHESIS:
The systematic search and Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update returned a total of 1202 articles, of which 1164 were excluded. The remaining 38 articles underwent a three-round modified Delphi process. In each round, articles were independently scored based on overall contribution to scientific knowledge and novelty to the literature. Included articles are summarized and their impact discussed. Article topics included hydrocortisone for severe community-acquired pneumonia, inhaled amikacin for prevention of ventilator-associated pneumonia, methylene blue for septic shock, restrictive vs. liberal fluid management for sepsis-induced hypotension, andexanet alfa for major bleeding associated with factor Xa inhibitors, and early administration of four-factor prothrombin complex concentrate in patients with trauma at risk for massive transfusion.

CONCLUSIONS:
This review provides a summary and perspective on the potential impact of the most relevant articles in 2023 describing advances in the pharmacotherapeutic care of critically ill patients.
De Novo Natural Language Processing Algorithm Accurately Identifies Myxofibrosarcoma From Pathology Reports
Authors: Lindsay Sarah E. , Madison Cecelia J. , Ramsey Duncan C. , Doung Yee-Cheen , Gundle Kenneth R. 
Published: October 2024

Background
Available codes in the ICD-10 do not accurately reflect soft tissue sarcoma diagnoses, and this can result in an underrepresentation of soft tissue sarcoma in databases. The National VA Database provides a unique opportunity for soft tissue sarcoma investigation because of the availability of all clinical results and pathology reports. In the setting of soft tissue sarcoma, natural language processing (NLP) has the potential to be applied to clinical documents such as pathology reports to identify soft tissue sarcoma independent of ICD codes, allowing sarcoma researchers to build more comprehensive databases capable of answering a myriad of research questions.

Questions/purposes
(1) What proportion of patients with myxofibrosarcoma within the National VA Database would be missed by searching only by soft tissue sarcoma ICD codes? (2) Is a de novo NLP algorithm capable of analyzing pathology reports to accurately identify patients with myxofibrosarcoma?

Methods
All pathology reports (10.7 million) in the national VA corporate data warehouse were identified from 2003 to 2022. Using the word-search functionality, reports from 403 veterans were found to contain the term “myxofibrosarcoma.” The resulting pathology reports were manually reviewed to develop a gold-standard cohort that contained only those veterans with pathologist-confirmed myxofibrosarcoma diagnoses. The cohort had a mean ± SD age of 70 ± 12 years, and 96% (287 of 300) were men. Diagnosis codes were abstracted, and differences in appropriate ICD coding were compared. An NLP algorithm was iteratively refined and tested using confounders, negation, and emphasis terms for myxofibrosarcoma. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for the NLP-generated cohorts through comparison with the manually reviewed gold-standard cohorts.

Results
The records of 27% (81 of 300) of myxofibrosarcoma patients within the VA database were missing a sarcoma ICD code. A de novo NLP algorithm more accurately (92% [276 of 300]) identified patients with myxofibrosarcoma compared with ICD codes (73% [219 of 300]) or basic word searches (74% [300 of 403]) (p < 0.001). Three final algorithm models were generated with accuracies ranging from 92% to 100%.

Conclusion
An NLP algorithm can identify patients with myxofibrosarcoma from pathology reports with high accuracy, which is an improvement over ICD-based cohort creation and simple word search. This algorithm is freely available on GitHub (https://github.com/sarcoma-shark/myxofibrosarcoma-shark) and is available to facilitate external validation and improvement through testing in other cohorts.

Level of Evidence
Level II, diagnostic study.
Investigating the Potential Short-term Adverse Effects of the Quadrivalent Human Papillomavirus Vaccine: A Novel Regression Discontinuity Analysis
Authors: Margelyte Ruta , Redaniel Maria Theresa , Walter Scott R. , Pyne Yvette , Merriel Sam , Macleod John , Northstone Kate , Tilling Kate 
Published: October 2024

Background:
Human papillomavirus (HPV) vaccination has been offered in over a hundred countries worldwide (including the United Kingdom, since September 2008). Controversy around adverse effects persists, with inconsistent evidence from follow-up of randomized controlled trials and confounding by indication limiting the conclusions drawn from larger-scale observational studies. This study aims to estimate the association between receiving a quadrivalent HPV vaccine and the reporting of short-term adverse effects and to demonstrate the utility of regression discontinuity design for examining side effects in routine data.

Methods:
We applied a novel regression discontinuity approach to a retrospective population-based cohort using primary care data from the UK Clinical Practice Research Datalink linked to hospital and social deprivation data. We examined the new onset of gastrointestinal, neuromuscular, pain, and headache/migraine symptoms using READ and International Classification of Diseases, tenth revision diagnostic codes. For each year between 2012 and 2017, we compared girls in school year 8 (born July/August) who were eligible to receive the vaccine with girls in year 7 (born September/October) who were not eligible.

Results:
Of the 21,853 adolescent girls in the cohort, 10,881 (50%) were eligible for HPV vaccination. There was no evidence of increased new gastrointestinal symptoms (adjusted odds ratio [OR]: 0.99; 95% confidence interval [CI]: 0.85, 1.15), headache/migraine symptoms (OR: 0.84; 95% CI: 0.70, 1.01), or pain symptoms (OR: 1.05; 95% CI: 0.95, 1.16) when comparing those eligible and ineligible for HPV vaccination.

Conclusion:
This study found no evidence that HPV vaccination eligibility is associated with reporting short-term adverse effects among adolescent girls.
Current opinions: updates on the changing landscape in the management of cervical cancer
Authors: Venkat Puja S. , Smick Alexandra H. , Salani Ritu 
Published: October 2024

Purpose of review
To review the recent updates in the management of cervical cancer across all stages of the disease.

Recent findings
After decades of minor advances, the landscape in cervical cancer is now rapidly changing. Recent studies have reported across the cervical cancer spectrum and on different therapeutic modalities. First, less radical surgery in the assessment and management of patients with early-stage, low-risk disease has been shown to be a safe option with reduced morbidity. The role of checkpoint inhibitor therapy in combination with chemotherapy and radiation has demonstrated improved survival outcomes, moving immunotherapy to earlier lines of therapy. The options for systemic therapy continue to include checkpoint inhibitors as well as treatment with antibody drug conjugates (ADCs) in the recurrent setting. Additional research continues to focus on targeting biomarkers in this disease.

Summary
In this paper, we will review the practice-changing trials impacting early stage, locally advanced, and recurrent cervical cancer patients. Despite advances, the limited survival for these patients continues to highlight the need for access to preventive healthcare (vaccine/cytology) and clinical trials to continue to make advances.
Trigeminal Trophic Syndrome With Herpetic Keratitis
Authors: Santos Matthew C. , Chen Howard C. 
Published: October 2024

Purpose:
The aim of this study was to report a rare observation of trigeminal trophic syndrome presenting with concurrent herpetic keratitis.

Methods:
This study was a case report.

Results:
A 42-year-old male with a remote history of a motor vehicle accident, traumatic brain injury, extensive facial reconstructive surgery, and traumatic optic neuropathy presented with left periorbital swelling. He was found to have extensive periorbital and total hypoesthesia in the cranial nerve V1 distribution and partial hypoesthesia in the V2 distribution. Corneal findings were highly suspicious for herpes simplex keratitis or zoster ophthalmicus. The patient was diagnosed with herpetic epithelial and stromal keratitis with periorbital ulceration secondary to Trigeminal trophic syndrome. The patient was treated broad spectrum intravenous antibiotics, intravenous acyclovir, and topical antibiotics. He was treated with topical steroids upon closure of epithelial defect. Upon discharge, the patient’s vision improved from hand-motion to 20/30 at near. The patient was later fit with a custom thermoplastic facial mask to minimize further selfinjurious behavior.

Conclusions:
To our knowledge, this is the first report of trigeminal trophic syndrome presenting with concurrent herpetic keratitis. Successful treatment requires a multidisciplinary approach to provide the patient insight and create protective equipment.
Trends and Factors Affecting Functional Limitations on Activities of Daily Living Performance Among Korean Adults With Disabilities, 2008–2020: A Longitudinal Study
Authors: OH Eunmi , NGUYEN Van Cuong , MOON SeolHwa , CHOI Rina , HONG Gwi-Ryung Son 
Published: October 2024

ABSTRACT

Background
Loss of the ability to perform activities of daily living (ADLs) leads to negative health outcomes such as reduced quality of life, institutionalization, and mortality. In Korea, the proportion of older adults with disabilities is increasing along with rapid population aging. Therefore, providing a comprehensive approach to the prevention and management of ADL limitations in people with disabilities is necessary. This can be accomplished by understanding the trends and factors affecting these limitations over time.

Purpose
This study was developed to examine the longitudinal trend and factors affecting ADL limitations over time among people with disabilities in Korea.

Methods
Data from 346 people with disabilities in the 2008–2020 Korean Welfare Panel Study were used. Bivariate analysis and a Kendall trend test were performed to determine the longitudinal trends for ADL limitations, and multiple logistic regression was used to evaluate whether relevant variables could predict these limitations.

Results
The prevalence of ADL limitations among people with disabilities increased by 16.5% over the 12 years of the study. The highest rate of increase in these limitations over time was found in people with mental disorders (27.8%), those over 65 years of age (27.3%), and those with depression (25.6%). In multiple logistic regression, the odds ratios of the variables were slightly different at each survey wave. However, severe disability and low educational level were consistently found to be associated with ADL limitations over time.

Conclusions
The findings provide evidence of a significant relationship between level of disability and/or educational status and ADL limitations in people with disabilities in Korea. To prevent the development of ADL limitations in people with disabilities, comprehensive identification of longitudinal trends and factors affecting ADL limitations is necessary. Early intervention, including integrated services such as home rehabilitation services to prevent ADL limitations, especially for disabled people with severe disabilities and low educational levels, has the potential to delay ADL limitations.
Implementing a Care-Based Nursing Workforce Model
Authors: Polancich Shea , Dick Tracey , Ledlow Jennifer , White-Williams Connie , Chambers Amanda , Thomas Keri , Poe Terri , Miltner Rebecca 
Published: October 2024

Background:
Nursing care delivery models may serve as a significant factor contributing to nurse satisfaction, frequency of missed care, and patient outcomes.

Local problem:
The nursing leadership team at our institution sought to determine if an adaptation of our primary registered nurse (RN) nursing model would enhance satisfaction of bedside nurses and care of patients.

Methods:
An improvement study introducing a care-based delivery model was implemented between January 2023 and January 2024 on a medical-surgical neurology/spinal unit at our organization.

Interventions:
Adoption of a care-based nursing model was supported with the delivery of brief education sessions utilizing in situ simulations for development of competencies in teamwork and delegation.

Results:
During the pilot period, overall satisfaction with job role improved 23%. Six missed nursing care elements and 7 teamwork elements significantly improved.

Conclusions:
A care-based nursing model may improve staff satisfaction and quality of nursing care.
Easily Missed Lung Cancer Associated With Cystic Airspaces
Authors: Wang Kangkang , Huang Hao 
Published: October 2024

Abstract
Lung cancer associated with cystic airspaces represents a distinctive subtype of pulmonary malignancies, characterized by the presence of cystic airspaces within or adjacent to the tumor, as identified through imaging studies. The absence of standardized terminology and limited understanding of these malignancies have led to inconsistent descriptions, often referred to as “cancers arising from lung cysts” or “cancers associated with cystic airspaces.” In this article, we present a case of a 77-year-old woman diagnosed with both typical lung cancer and lung cancer associated with cystic airspaces.
Transient Posterior Layering of 18F-FDG in Distended Bladders
Authors: Wang Kangkang , Li Zhenyu 
Published: October 2024

Abstract
Urine activity layering in the bladder sometimes appears in PET/CT scans, but a comprehensive explanation for this phenomenon is still lacking. Previous studies have not documented the dynamic changes of layering in vivo. We present 2 cases of posterior layering in the urinary bladder on 18F-FDG PET/CT scans, which gradually diminished and ultimately disappeared in delayed phase images. Both patients had normal renal function and no signs of urinary tract infection.
Utility of Lactate Levels in the Diagnosis and Prognosis of Septic Shock
Authors: de Souza Daniela Carla , Jabornisky Roberto , Kissoon Niranjan 
Published: October 2024

Abstract
Early recognition of septic shock and its treatment are key factors for limiting progression to multiple organ dysfunction and death. Lactate, a byproduct of metabolic pathways, is usually elevated in tissue hypoperfusion and shock and is associated with poor prognosis in sepsis. As a biomarker, it may help the clinician in risk stratification, and the identification and treatment of sepsis. In this article, we provide an update on lactate's pathophysiology and role in diagnosis, treatment, and prognosis in children with sepsis and septic shock.
68Ga-DOTA-FAPI-46 PET/CT Imaging for Restaging in a Patient With Metastatic Pheochromocytoma
Authors: Şahin Rahime , Baloğlu Mehmet Can , Ergül Nurhan , Çermik Tevfik Fikret , Arslan Esra 
Published: October 2024

Abstract
Pheochromocytomas (PHEOs) are neural crest-derived tumors originating from the chromaffin cells of the adrenal medulla and were recognized as one of the subtypes of paragangliomas by the World Health Organization in 2022. 68Ga-labeled somatostatin analog (68Ga-DOTA-NOC, 68Ga-DOTA-TOC, and 68Ga-DOTA-TATE) PET imaging has shown significant performance compared with 123MIBG scintigraphy in the diagnosis of paragangliomas. It is now known that fibroblast activation protein (FAP) is overexpressed by various cancer-associated fibroblasts, including PHEOs. We would like to present the findings of 68Ga-DOTA-FAPI-46 PET/CT and 68Ga-DOTA-TATE PET/CT imaging performed for restaging on a 42-year-old man diagnosed with metastatic PHEO.
“Cancer Integrin” αvβ6 Imaging With 68Ga-Trivehexin PET/CT in Assessment of Ovarian Carcinoma
Authors: Singh Parneet , Agrawal Kanhaiyalal , Emerson Ralph , Baranwal Abhinav , Patro P. Sai Sradha , Parida Girish Kumar 
Published: October 2024

Abstract
Peritoneal cancer index is an integral parameter for preoperative assessment of peritoneal disease. Current imaging modalities including 18F-FDG PET/CT, though superior to CT, underestimate the disease extent, mainly due to its high physiological background activity. Novel “cancer integrin” targeting imaging with 68Ga-trivehexin demonstrates limited physiological activity in the abdomen with superior target-to-background ratio than 18F-FDG PET/CT. Thus, we describe the first case demonstrating potential utility of novel “cancer integrin” αvβ6 imaging agent 68Ga-trivehexin for assessment of disease burden in advanced epithelial ovarian cancer.
Increased TSPO, COX-1, and COX-2 Uptake in Bone Marrow Within a Falx Cerebri Ossification
Authors: Yan Xuefeng , Siméon Fabrice G. , Pike Victor W. , Innis Robert B. , Zanotti-Fregonara Paolo 
Published: October 2024

Abstract
Ossification is uncommon, generally asymptomatic, and often incidentally identified in imaging studies. We report on a 54-year-old man who participated as a healthy volunteer in a clinical trial using PET imaging to investigate neuroinflammation. An incidental ossified lesion in the anterior falx cerebri was revealed by MRI. CT scan showed a small hypodense center in the lesion, probably corresponding to bone marrow. The PET scans using 18F-SF51, 11C-PS13, and 11C-MC1 showed increased uptake within this lesion, which was probably related to bone marrow activity within the ossification.
Mandible Fracture Outcome Disparities in the Incarcerated Patient Population
Authors: Lewcun Joseph A. , Ghahrai Naomi , Donnelly Madeline , Luo Annie , Knighton Brooks , Shin Stephanie , Bernabe Rendell , Mountziaris Paschalia 
Published: October 2024

Introduction
Inmates represent a vulnerable health care population within the United States, with inconsistent access to surgical specialty care. Facial fractures are common among the incarcerated population, comprising approximately 14% of all traumatic injuries. However, few studies have evaluated facial fracture outcomes in this population. The aim of this study is to identify disparities in mandible fracture outcomes in the incarcerated population.

Methods
A retrospective review of all isolated traumatic mandible fractures at a single academic medical center from 2018 to 2023 was conducted. Mandible fractures were treated by plastic surgery, otolaryngology, or oral and maxillofacial surgery. Outcome measures such as rates of persistent malocclusion, motor deficits, surgical site infection, reoperation, and readmission were compared between inmate and civilian subgroups.

Results
A total of 205 patients (mean age, 33.1 years; 81.5% male) who were treated for isolated traumatic mandible fracture were included. A minority of patients (11.7%; n = 24) were inmates, whereas 88.3% (n = 181) were civilians. The mean time to operative intervention was 10.2 days in the incarcerated group and 4.4 days in the civilian group (P < 0.05). Persistent subjective malocclusion after surgery was noted in 20.8% (n = 5) of incarcerated patients and 7.2% (n = 13) of civilian patients (P < 0.05). There were no significant differences in rates of surgical site infection, reoperation, persistent motor deficits, or readmissions within 30 days.

Conclusions
Incarcerated patients with traumatic mandible fractures have increased time to operative intervention and increased rates of subjective malocclusion postoperatively. Increased time to operative intervention may reflect barriers in access to specialty surgical care, which could adversely affect patient outcomes.
Call to Action
Authors: Lu Amy , Pian-Smith May C. M. , Burden Amanda , Fernandez Gladys L. , Fortner Sally A. , Rege Robert V. , Slakey Douglas P. , Velasco Jose M. , Cooper Jeffrey B. , Steadman Randolph H. 
Published: October 2024

Summary Statement
Simulation is underutilized as a tool to improve healthcare quality and safety despite many examples of its effectiveness to identify and remedy quality and safety problems, improve teamwork, and improve various measures of quality and safety that are important to healthcare organizations, eg, patient safety indicators. We urge quality and safety and simulation professionals to collaborate with their counterparts in their organizations to employ simulation in ways that improve the quality and safety of care of their patients. These collaborations could begin through initiating conversations among the quality and safety and simulation professionals, perhaps using this article as a prompt for discussion, identifying one area in need of quality and safety improvement for which simulation can be helpful, and beginning that work.