bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of neighborhood perceptions on response to a technology-assisted parenting intervention for adolescent substance use: protocol of a diversity supplement to parent SMART (Substance Misuse in Adolescents in Residential Treatment)
Authors: Patel-Syed Zabin , Helseth Sarah A. , Rosales Robert , Janssen Tim , Scott Kelli , Becker Sara J. 
Published: October 2024

Abstract
Background
It is well established that an adolescent’s neighborhood is associated with their likelihood of developing a substance use disorder. The availability of drugs, lack of access to resources, and exposure to violence are all associated with greater substance use among young people, leading to more pronounced health inequities. Technology assisted interventions (TAIs) have been touted to enhance the reach of substance use treatment and improve outcomes for high-need families living in underserved neighborhoods. A key question is whether neighborhood characteristics impact the effectiveness of TAIs, given these interventions are embedded within an adolescent’s natural environment. This National Institute on Drug Abuse-funded Diversity Supplement will examine the role of perceived neighborhood characteristics on response to Parent SMART, a TAI for parents of adolescents in residential substance use treatment (R37DA052918; PI: Becker). Aim 1 will use both adolescent and parent self-report of multiple neighborhood dimensions (e.g., physical environment, social disorder, satisfaction with community resources) to identify indicators predictive of treatment response. Aim 2 will then explore the indirect relationship between neighborhood context and response to Parent SMART, via engagement.

Methods
Participants include adolescent and parent dyads enrolled in an effectiveness trial evaluating Parent SMART, a TAI for parents of adolescents in residential substance youth treatment. Participants will complete self-report measures of neighborhood physical environment, social disorder, and satisfaction with community resources at baseline to predict parenting and youth substance outcomes at 6-, 12-, and 24-weeks post discharge.

Discussion
To date, few studies have explicitly tested how neighborhood affects response to TAIs for adolescent substance use. Assessing adolescent and parent perceptions of neighborhood characteristics holds potential to pinpoint key contextual factors that affect TAI response and to promote consideration of multi-level health equity determinants in substance use research. Understanding neighborhood influences can advance public health by helping tailor TAIs to address the unique needs of adolescents living in underserved communities.

Trial registration
This study extends the measurement and analysis plan of a pragmatic effectiveness trial. The pragmatic effectiveness trial is registered at ClinicalTrials.gov NCT05169385; https://clinicaltrials.gov/ct2/show/NCT05169385
Deciphering LAG-3: unveiling molecular mechanisms and clinical advancements
Authors: Martínez-Pérez Alejandra , Granda-Díaz Rocío , Aguilar-García Candelaria , Sordo-Bahamonde Christian , Gonzalez Segundo 
Published: October 2024

AbstractTreatment based on immune checkpoint blockade has revolutionized cancer therapy. Despite the remarkable success achieved and the preclinical development of multiple checkpoint inhibitors targeting other checkpoints, only antibodies targeting the PD-1/PD-L1 axis and CTLA-4 have been approved for patient treatment, especially in solid tumors. Currently, with the approval of relatlimab, a LAG-3 blocking antibody, a third player, has been used in the fight against cancer. The endorsement of relatlimab marks a significant milestone in cancer immunotherapy, opening new avenues for combination therapies and enhancing treatment outcomes. However, the complex biology of LAG-3 may hinder its full development as a therapeutic alternative. In this review, we provide in-depth insight into the biology of LAG-3 and its current and future development in cancer treatment.
Experimental study evaluating the performance of thermal conductivity prediction models for air–water saturated weathered sandstone heritage
Authors: Hu Jinshuai , Huang Jizhong , Cheng Yuan 
Published: October 2024

Abstract
As a critical parameter, thermal conductivity directly determines the heat transfer and temperature variation within rocks, which can lead to mechanical damage and chemical corrosion. Consequently, understanding the thermal conductivity of stone heritage is vital for assessing their deterioration mechanisms and developing effective conservation strategies. This study obtained sandstone samples from the Yungang Grottoes and subjected them to freeze–thaw cycle experiments to generate weathered sandstone samples. Subsequently, the thermal conductivity of these samples was measured under both dry and water-saturated state using the transient plane source method. To analyze the relationship between air–water saturation, porosity, and thermal conductivity, a saturation influence coefficient was introduced. Thereafter, the effectiveness and applicability of 13 commonly used thermal conductivity mixing law prediction models were evaluated based on experimental data. The results suggested that the influence of water saturation on the thermal conductivity of rocks varies with porosity, and water saturation significantly enhances the thermal conductivity of weathered sandstone. Among the 13 common models, the Geometric mean model was found to be more accurate than other models, with superior performance in both dry (MAE, RMSE, MAPE are 0.148, 0.214, 5.59% respectively) and water-saturated (MAE, RMSE, MAPE are 0.244, 0.170, 8.4% respectively) state. The Albert model demonstrates a good fit in the dry state, whereas the Walsh model (with maximum effect), Ribaud model, and Huang model also exhibit good fitting efficacy in the water-saturated state. This study provides a solid foundation for better predicting the thermal conductivity of weathered stone heritage and developing effective preventive conservation strategies.
Effective multi-biocatalyst system with reusable NADH for transformation of glycerol to value-added dihydroxyacetone
Authors: Wee Youngho , Kumar Gudi Satheesh , Kim Seongbeen , Zhao Xueyan Sarah , Wang Ping , Lee Jinwoo , Hwang Ee Taek , Kim Jungbae 
Published: October 2024

AbstractGlycerol-based biorefinery can be a highly profitable process by producing highly value-added products such as dihydroxyacetone via combined catalytic strategies. Here, two-enzyme system is adopted for the transformation of glycerol into highly valuable dihydroxyacetone as well as cofactor regeneration at the same time. Glycerol dehydrogenase (GDH) and alcohol dehydrogenase (ADH) are co-immobilized within magnetically separable and spherical mesocellular silica foam (Mag-S-MCF), to prepare NER-(GDH/ADH). In details, GDH and ADH are adsorbed into the mesopores of Mag-S-MCF, and further crosslinked within the mesopores of Mag-S-MCF. The resulting nanoscale enzyme reactors (NER) of crosslinked GDH and ADH molecules within the bottle-neck structured mesopores can effectively prevent larger sized crosslinked enzyme aggregates from being leached out of smaller mesopores, due to the bottle-neck mesopore structure of Mag-S-MCF, as well as stabilize the activity of GDH and ADH upon chemical crosslinking, effectively preventing the denaturation of enzyme molecules. More importantly, the proximity of GDH and ADH molecules within mesopores of NER improves the efficiency of cofactor-mediated dual-enzymatic reactions by relieving mass-transfer limitations and improving cofactor recycling in an effective way, expediting both glycerol oxidation and dihydroxyacetone generation at the same time. As a result, the DHA concentration of NER-(GDH/ADH) and the simple mixture of NER-GDH and NER-ADH were 410 μM and 336 μM, respectively. To the best of our knowledge, this report is the first demonstration of stabilized nanoscale multi-enzyme reactor system, equipped with efficient cofactor regeneration within confined mesopores, for efficient glycerol transformation to high-valued dihydroxyacetone.
Graphical Abstract
Engineering a high-sugar tolerant strain of Saccharomyces cerevisiae for efficient trehalose production using a cell surface display approach
Authors: Tulsook Kan , Bussadee Piyada , Arnthong Jantima , Mhuantong Wuttichai , U-thai Panida , Trakarnpaiboon Srisakul , Champreda Verawat , Suwannarangsee Surisa 
Published: October 2024

AbstractTrehalose production via a one-step enzymatic route using trehalose synthase (TreS) holds significant promise for industrial-scale applications due to its simplicity and utilization of low-cost substrates. However, the development of a robust whole-cell biocatalyst expressing TreS remains crucial for enabling practical and economically viable production. In this study, a high-sugar tolerant strain of S. cerevisiae was screened and employed as a host cell for the cell surface display of TreS from Acidiplasma aeolicum. The resultant strain, S. cerevisiae I3A, exhibited remarkable surface displayed TreS activity of 3358 U/g CDW and achieved approximately 64% trehalose yield (10.8 g/L/h productivity) from maltose. Interestingly, no glucose by-product was observed during trehalose production. The S. cerevisiae I3A cells exhibited reusability for up to 12 cycles leading to potential cost reduction of trehalose products. Therefore, our study demonstrated the development of a high-sugar tolerant S. cerevisiae strain expressing TreS on its surface as a whole-cell biocatalyst for efficient and economical trehalose production with potential applications in the food and pharmaceutical industries.
Challenges associated with the implementation of institutional quarantine and isolation strategies during major multicountry viral outbreaks in Africa (2000–2023): a scoping review
Authors: Amzat Jimoh , Oduwole Ebunoluwa , Lawal Saheed Akinmayowa , Aluko-Arowolo Olusola , Afolabi Rotimi , Adedeji Isaac Akinkunmi , Temisan Ige Angela , Oludiran Ayoyinka , Aminu Kafayat , Salami Afeez Abolarinwa , Kanmodi Kehinde Kazeem 
Published: October 2024

Abstract
Background
Quarantine and isolation (Q&I) are interrelated but not mutually exclusive public health practices for disease control, which may face public resistance in the context of health emergencies due to associated challenges. Hence, it is often tough for most countries to implement Q&I even in the context of health emergencies. Therefore, this scoping review examines the challenges associated with the implementation of institutional Q&I strategies during major multicountry viral outbreaks (Ebola, Lassa and COVID-19) in Africa between 2000 and 2023.

Methods
This scoping review was designed based on Arksey and O’Malley’s guidelines. A systematic literature search, using nine online research databases, was conducted with the aid of relevant search terms, Boolean operators and truncations. All articles obtained from the literature search were electronically imported into Rayyan web application for deduplication based on specific inclusion and exclusion criteria. From the included literature, relevant data were charted, summarized, collated, and presented.

Results
This review included 24 of the 787 retrieved articles. Sixteen of the 24 selected articles investigated issues related to COVID-19 prevention and control in Africa. Two assessed precautionary practices for Lassa fever, while five were on Ebola virus disease. However, one article explored knowledge, preventive practices, and general isolation precautions. The review identified various challenges that hindered the implementation of successful Q&I practices during viral infection outbreaks in Africa. Essential healthcare infrastructure, equipment (medical supplies including personal protective equipment and testing kits) and facilities that are essential for Q&I were deficient. Q&I implementation was often threatened by low human resource capacity and inefficiencies in the healthcare system which portray Africa as unprepared to handle complex public health crises.

Conclusions
This review shows that Q&I implementation in Africa is often threatened by low human resource capacity and inefficiencies in the healthcare system and also portrays Africa as unprepared to handle complex public health crises. Hence, Q&I for major multicountry outbreaks in Africa is very challenging. Therefore, continuous efforts to address these identified challenges are crucial to enhancing health emergency preparedness in Africa.
Cluster randomized trial of a team communication training implementation strategy for depression screening in a pediatric healthcare system: a study protocol
Authors: Stadnick Nicole A. , Aarons Gregory A. , Edwards Hannah N. , Bryl Amy W. , Kuelbs Cynthia L. , Helm Jonathan L. , Brookman-Frazee Lauren 
Published: October 2024

Abstract
Background
Pediatric depression is a global concern that has fueled efforts for enhanced detection and treatment engagement. As one example, the US Preventive Services Task Force recommends depression screening for adolescents ages 12–18 years. While many health systems have implemented components of depression screening protocols, there is limited evidence of effective follow-up for pediatric depression. A key barrier is timely team communication and coordination across clinicians and staff within and across service areas for prompt service linkage. However, team effectiveness interventions have been shown to improve team processes and outcomes and can be applied in healthcare settings.

Methods
This project aims to refine and test a team communication training implementation strategy to improve implementation of an existing pediatric depression screening protocol in a large pediatric healthcare system. The team will be defined as part of the study but is expected to include medical assistants, nurses, physicians, and behavioral health clinicians within and across departments. The implementation strategy will target team mechanisms at the team-level (i.e., intra-organizational alignment and implementation climate) and team member-level (i.e., communication, coordination, psychological safety, and shared cognition). First, the project will use mixed methods to refine the team training strategy to fit the organizational context and workflows. Next, a hybrid type 3 implementation-effectiveness pilot trial will assess the initial effectiveness of the team communication training (implementation strategy) paired with the current universal depression screening protocol (clinical intervention) on implementation outcomes (i.e., feasibility, acceptability, appropriateness, workflow efficiency) and clinical/services outcomes (increased frequency of needed screening and reduced time to service linkage). Finally, the study will assess mechanisms at the team and team member levels that may affect implementation outcomes.

Discussion
Team communication training is hypothesized to lead to improved, efficient, and effective decision-making to increase the compliance with depression screening and timely service linkage. Findings are expected to yield better understanding and examples of how to optimize team communication to improve efficiency and effectiveness in the pediatric depression screening-to-treatment cascade. This should also culminate in improved implementation outcomes including patient engagement critical to address the youth mental health crisis.

Trial registration
NCT06527196.
Trial Sponsor: University of California San Diego.
Is too much insight bad for you?
Authors: Lopez-Morinigo Javier-David , David Anthony S. 
Published: October 2024

SummaryInsight in psychosis is associated with reduced psychotic symptom severity, less coercive treatment and better functioning. Controversially, it has been suggested that insight may lead to depression, higher suicide risk and worse self-perceived quality of life. Future clinical trials are warranted to address this ‘insight paradox’, particularly the direction of causality.
Primary Paraganglioma Arising From the Maxillary Bone
Authors: Chuki Elias , Saleh Anaraki Kimia , Jha Abhishek , Patel Mayank , Ling Alexander , Pacak Karel 
Published: October 2024

Abstract
We present a unique case of primary intraosseous paraganglioma (PGL) originating from maxillary bone. PGL is a neurosecretory neoplasm that arises from cells believed to originate from the neural crest. A 30-year-old woman presented with right facial pain and swelling, along with palpitations. Computed tomography (CT) imaging revealed a 3.3 × 3.1 × 2.3 cm mass in the anterior maxilla, and biochemical results showed elevated plasma dopamine, 3-methoxytyramine, and chromogranin A levels. Biopsy confirmed a PGL, with positive expression of synaptophysin, chromogranin A, and GATA-3. Whole-body positron emission tomography/computed tomography (PET/CT) scans showed avidity on 18F-fluorodopa (18F-FDOPA), 68Ga-DOTA(0)-Tyr(3)-octreotate ​​ (68Ga-DOTATATE), and 18F-fluorodeoxyglucose (18F-FDG). No other lesions (primary or metastatic) were found. Proton beam therapy was chosen over surgery due to potential complications and patient's preference. Following radiotherapy, she experienced symptom relief, with dopamine levels decreasing and chromogranin A normalizing, with the lesion remaining stable on 11-month follow-up imaging. This case highlights the rarity of primary bone PGLs and underscores the importance of comprehensive diagnostic approaches combining physical examinations, biochemical testing, functional imaging, and histopathological analysis properly guiding personalized treatment strategies. Additionally, proton beam therapy emerges as a highly suitable treatment option for head and neck paragangliomas (HNPGLs), offering effective tumor control with minimal complications.
Clandestine Issues
Authors: Alemu Amsale 
Published: October 2024

Abstract
To this day, materials surrounding the 1974 Ethiopian Revolution that live in the archives of Addis Ababa University are designated as “clandestine literature.” Their publication was a clandestine affair; critiquing the emperor of the then-oldest Christian kingdom in the world and eventually professing Marxist thinking, they amounted to blasphemy. However, building an argument for Ethiopian revolution was premised on another heretical proposition: that Ethiopia, world-famous for having eluded European colonial rule, was a client state of US imperialism during the mid-century age of decolonization. This article employs a selection of Ethiopian revolutionary papers—including magazines, newspapers, and journals produced and distributed across Ethiopia, North America, and Europe—to provide a genealogy of “US Imperialism in Ethiopia,” a composite, hand-transcribed document of the late 1960s that has since been destroyed. Assembling materials marked by both their refutation of and proximity to US empire, this article argues that building the case for US imperialism in Ethiopia was a necessary step to clarify and link Ethiopian revolutionary struggle to anticolonialism. In the process, the article thinks with and extends the archival designation “clandestine” as both the conspiracy of alleging US imperialism in Ethiopia and an analytic for reading other transnational networks of revolutionary papers.
“Critical Realisms” in Savera
Authors: Akhtar Areej , Ahmad Javaria , Khan Sana Farrukh 
Published: October 2024

Abstract
This teaching tool is based on Savera (Dawn), a left-wing literary periodical published quarterly on the Indian subcontinent from 1946 onward under the leadership of the Progressive Writers’ Movement. The tool foregrounds the genealogy of “critical realism,” a revolutionary form of Urdu realism that perpetuated the movement’s aim of bringing about social transformation in a former colony by critiquing India’s indigenous conceptions of class, gender, nationalism, language, and religion.
Assessment of serum protein profile in sickle cell disease
Authors: Ibrahim Munirudeen , Yakub Hafiz Abiodun , Garuba Wasiu O. , Ogunniyi Tolulope , Lawal Abubakar Z. , Adunmo Godwin O. , Ogunwale Kola A , Busari Akeem O. , Popoola AbdulGafar N , Eleha Suleiman I. , Nuhu Abdulrazak , Ibrahim Musbaudeen 
Published: October 2024

Background: Sickle Cell disease (SCD) is known to be caused by a mutation in the beta-globin gene of the hemoglobin that affects the red blood cells (RBCs) and is passed down through generations. This study was carried out to determine the effect of sickling of RBC on serum protein profile in SCD individuals.
Methods: A case-controlled study was carried out among 80 patients. They were forty-five sickle cell disease individuals (HbSS) attending Children Specialist Hospital Ilorin and thirty-five healthy controls (HbAA). The levels of total protein and albumin were determined spectrophotometrically and serum protein electrophoresis (SPE) was carried out using cellulose acetate electrophoresis.
Results: Significant hypoalbuminemia and hypergammaglobulinemia were observed in SCD groups compared with controls. A higher proportion of the SCD group, 11(25%) had hypergammaglobulinemia and 21(49%) had hypoalbuminemia (P<0.05). Plasma protein electrophoresis in SCD patients shows an intense colour at the gamma region which was not seen in control. There was a significant relationship between the patterns of serum protein electrophoresis and the frequency of crisis.
Conclusions: Sickle cell disease crisis and other associated underlying conditions may be prevented early through assessment of serum protein profile, especially SPE. Hypergammaglobulinemia and hypoalbuminemia may be associated with frequent episode of crisis.