bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifewide, lifelong comprehensive approach to knowledge management education – emerging standards
Authors: Bedford Denise A.D. , Georgieff Marion , Brown-Grant Johel 
Published: October 2017

Purpose
The purpose of this study is to propose a framework for developing standards for knowledge management education programs from primary through tertiary levels. The lack of standards for knowledge management education is a significant challenge for the advancement of the field, for the sustainability of institutional programs, the future competencies of knowledge workers and the effective growth of knowledge organizations.

Design/methodology/approach
The research adopts and adapts the framework and methodology used to establish educational standards in computer science. The framework is presented as a focal point for discussion across the profession. Nine strands are derived from historical treatment of the discipline. Seven levels of learning are identified. Learning goals and objectives are developed for each level.

Findings
The research suggests that a lifelong learning model is definable for the field of knowledge management, just as it has been for other disciplines. The progressive learning model may produce high school graduates who are better prepared for knowledge work, a larger population of knowledge practitioners and professionals prepared to support and lead knowledge organizations and increased quantities and improved quality of knowledge management research. Finally, the progressive learning model may generate a new and increased demand for lifelong learning opportunities in the field of knowledge management.

Research limitations/implications
The research is intended as a focal point for discussion and review by knowledge management professionals and particularly educators around the globe. The research represents an important stage of development, but adoption is the final stage of this research.

Originality/value
While this research draws upon established theories and practices in the field, and learning frameworks from other domains, the context and the research results are unique.
Bacterial microbiomes of individual ectomycorrhizal Pinus sylvestris roots are shaped by soil horizon and differentially sensitive to nitrogen addition
Authors: Marupakula Srisailam , Mahmood Shahid , Jernberg Johanna , Nallanchakravarthula Srivathsa , Fahad Zaenab A. , Finlay Roger D. 
Published: October 2017

SummaryPlant roots select non‐random communities of fungi and bacteria from the surrounding soil that have effects on their health and growth, but we know little about the factors influencing their composition. We profiled bacterial microbiomes associated with individual ectomycorrhizal Pinus sylvestris roots colonized by different fungi and analyzed differences in microbiome structure related to soils from distinct podzol horizons and effects of short‐term additions of N, a growth‐limiting nutrient commonly applied as a fertilizer, but known to influence patterns of carbon allocation to roots. Ectomycorrhizal roots growing in soil from different horizons harboured distinct bacterial communities. The fungi colonizing individual roots had a strong effect on the associated bacterial communities. Even closely related species within the same ectomycorrhizal genus had distinct bacterial microbiomes in unfertilized soil, but fertilization removed this specificity. Effects of N were rapid and context dependent, being influenced by both soil type and the particular ectomycorrhizal fungi involved. Fungal community composition changed in soil from all horizons, but bacteria only responded strongly to N in soil from the B horizon where community structure was different and bacterial diversity was significantly reduced, possibly reflecting changed carbon allocation patterns.
Strong impact of anthropogenic contamination on the co‐occurrence patterns of a riverine microbial community
Authors: Hu Anyi , Ju Feng , Hou Liyuan , Li Jiangwei , Yang Xiaoyong , Wang Hongjie , Mulla Sikandar I. , Sun Qian , Bürgmann Helmut , Yu Chang‐Ping 
Published: October 2017

SummaryAlthough the health of rivers is threatened by multiple anthropogenic stressors with increasing frequency, it remains an open question how riverine microbial communities respond to emerging micropollutants. Here, by using 16S rDNA amplicon sequencing of 60 water samples collected during different hydrological seasons, we investigated the spatio‐temporal variation and the co‐occurrence patterns of microbial communities in the anthropogenically impacted Jiulong River in China. The results indicated that the riverine microbial co‐occurrence network had a nonrandom, modular structure, which was mainly shaped by the taxonomic relatedness of co‐occurring species. Fecal indicator bacteria may survive for prolonged periods of time in river water, but they formed an independent module which had fewer interactions with typical freshwater bacteria. Multivariate analysis demonstrated that nutrients and micropollutants [i.e., pharmaceuticals and personal care products (PPCPs)] exerted combined effects in shaping α‐ and β‐diversity of riverine microbial communities. Remarkably, we showed that a hitherto unrecognized disruptive effect of PPCPs on the abundance variations of central species and module communities was stronger than the influence of physicochemical factors, suggesting the key role played by micropollutants for the microbial co‐occurrence relationships in lotic ecosystems. Overall, our findings provide novel insights into community assembly in aquatic environments experiencing anthropogenic stresses.
Untangling the cecal microbiota of feral chickens by culturomic and metagenomic analyses
Authors: Ferrario Chiara , Alessandri Giulia , Mancabelli Leonardo , Gering Eben , Mangifesta Marta , Milani Christian , Lugli Gabriele Andrea , Viappiani Alice , Duranti Sabrina , Turroni Francesca , Ossiprandi Maria Cristina , Hiyashi Ricardo , Mackie Roderick , van Sinderen Douwe , Ventura Marco 
Published: October 2017

SummaryDifferent factors may modulate the gut microbiota of animals. In any particular environment, diet, genetic factors and human influences can shape the bacterial communities residing in the gastrointestinal tract. Metagenomic approaches have significantly expanded our knowledge on microbiota dynamics inside hosts, yet cultivation and isolation of bacterial members of these complex ecosystems may still be necessary to fully understand interactions between bacterial communities and their host. A dual approach, involving culture‐independent and ‐dependent techniques, was used here to decipher the microbiota communities that inhabit the gastro intestinal tract of free‐range, broiler and feral chickens. In silico analysis revealed the presence of a core microbiota that is typical of those animals that live in different geographical areas and that have limited contact with humans. Anthropic influences guide the metabolic potential and the presence of antibiotic resistance genes of these different bacterial communities. Culturomics attempts, based on different cultivation conditions, were applied to reconstruct in vitro the microbiota of feral chickens. A unique strain collection representing members of the four major phyla of the poultry microbiota was assembled, including bacterial strains that are not typically retrieved from the chicken gut.
Fragmentation in Urban Movements: The Role of Urban Planning Processes
Authors: Özdemir Esin , Eraydin Ayda 
Published: October 2017

AbstractUrban plans and projects that aim to initiate the redevelopment and gentrification of urban areas create social and ecological pressures on urban environments and thereby stimulate urban movements. These movements have a lifespan, which evolves in interaction with planning authorities under local or central governments and may be marked by institutionalization and co‐optation, as well as fragmentation among the people involved in them. Fragmentations are usually based on conflicting individual and collective interests, but may also be the result of different political perspectives in groups. This article is based on a case study conducted in two adjacent gecekondu neighbourhoods of Istanbul, Gülsuyu and Gülensu, where urban politics have played an important role in efforts to resist plans for urban transformation. It shows that fragmentations are very likely to occur in urban movements during planning processes in a neoliberal era, owing to the different perspectives in the movement on what the just city is.
Immuno‐pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord
Authors: Olivero Guendalina , Bonfiglio Tommaso , Vergassola Matteo , Usai Cesare , Riozzi Barbara , Battaglia Giuseppe , Nicoletti Ferdinando , Pittaluga Anna 
Published: October 2017

Background and PurposeWe recently proposed the existence of mGlu3‐preferring autoreceptors in spinal cord terminals and of mGlu2‐preferring autoreceptors in cortical terminals. This study aims to verify our previous conclusions and to extend their pharmacological characterization.Experimental ApproachWe studied the effect of LY566332, an mGlu2 receptor positive allosteric modulator (PAM), and of LY2389575, a selective mGlu3 receptor negative allosteric (NAM) modulator, on the mGlu2/3 agonist LY379268‐mediated inhibition of glutamate exocytosis [measured as KCl‐evoked release of preloaded [3H]‐D‐aspartate]. The mGlu2 PAM BINA and the mGlu3 NAM ML337, as well as selective antibodies recognizing the N‐terminal of the receptor proteins, were used to confirm the pharmacological characterization of the native receptors.Key ResultsCortical synaptosomes possess LY566332‐sensitive autoreceptors that are slightly, although significantly, susceptible to LY2389575. In contrast, LY566332‐insensitive and LY2389575‐sensitive autoreceptors are present in spinal cord terminals. BINA and ML337 mimicked LY566332 and LY2389575, respectively, in controlling LY379268‐mediated inhibition of glutamate exocytosis from both cortical and spinal cord synaptosomes. Incubation of cortical synaptosomes with anti‐mGlu2 antibody prevented the LY379268‐induced inhibition of glutamate exocytosis, and this response was partially reduced by the anti‐mGlu3 antibody. Incubation of spinal cord synaptosomes with the anti‐mGlu3 antibody abolished LY379268‐mediated reduction of glutamate exocytosis from these terminals, while the anti‐mGlu2 antibody was inactive. Western blot analysis and confocal microscopy data were largely consistent with these functional observations.Conclusions and ImplicationsWe confirmed that mGlu3‐preferring autoreceptors exist in spinal cord terminals. Differently, cortical glutamatergic terminals possess mGlu2/mGlu3 heterodimers, whose inhibitory effect is largely mediated by mGlu2 receptors.
Reappraising the early evidence of durophagy and drilling predation in the fossil record: implications for escalation and the Cambrian Explosion
Authors: Bicknell Russell D. C. , Paterson John R. 
Published: October 2017

ABSTRACTThe Cambrian Explosion is arguably the most extreme example of a biological radiation preserved in the fossil record, and studies of Cambrian Lagerstätten have facilitated the exploration of many facets of this key evolutionary event. As predation was a major ecological driver behind the Explosion – particularly the radiation of biomineralising metazoans – the evidence for shell crushing (durophagy), drilling and puncturing predation in the Cambrian (and possibly the Ediacaran) is considered. Examples of durophagous predation on biomineralised taxa other than trilobites are apparently rare, reflecting predator preference, taphonomic and sampling biases, or simply lack of documentation. The oldest known example of durophagy is shell damage on the problematic taxon Mobergella holsti from the early Cambrian (possibly Terreneuvian) of Sweden. Using functional morphology to identify (or perhaps misidentify) durophagous predators is discussed, with emphasis on the toolkit used by Cambrian arthropods, specifically the radiodontan oral cone and the frontal and gnathobasic appendages of various taxa. Records of drill holes and possible puncture holes in Cambrian shells are mostly on brachiopods, but the lack of prey diversity may represent either a true biological signal or a result of various biases. The oldest drilled Cambrian shells occur in a variety of Terreneuvian‐aged taxa, but specimens of the ubiquitous Ediacaran shelly fossil Cloudina also show putative drilling traces. Knowledge on Cambrian shell drillers is sorely lacking and there is little evidence or consensus concerning the taxonomic groups that made the holes, which often leads to the suggestion of an unknown ‘soft bodied driller’. Useful methodologies for deciphering the identities and capabilities of shell drillers are outlined. Evidence for puncture holes in Cambrian shelly taxa is rare. Such holes are more jagged than drill holes and possibly made by a Cambrian ‘puncher’. The Cambrian arthropod Yohoia may have used its frontal appendages in a jack‐knifing manner, similar to Recent stomatopod crustaceans, to strike and puncture shells rapidly. Finally, Cambrian durophagous and shell‐drilling predation is considered in the context of escalation – an evolutionary process that, amongst other scenarios, involves predators (and other ‘enemies’) as the predominant agents of natural selection. The rapid increase in diversity and abundance of biomineralised shells during the early Cambrian is often attributed to escalation: enemies placed selective pressure on prey, forcing phenotypic responses in prey and, by extension, in predator groups over time. Unfortunately, few case studies illustrate long‐term patterns in shelly fossil morphologies that may reflect the influence of predation throughout the Cambrian. More studies on phenotypic change in hard‐shelled lineages are needed to convincingly illustrate escalation and the responses of prey during the Cambrian.
Accounting for Sustainable Development over the Long-Run: Lessons from Germany
Authors: Blum Matthias , McLaughlin Eoin , Hanley Nick 
Published: October 2017

AbstractWe construct long-run sustainability indicators based on changes in Comprehensive Wealth - which we refer to as Genuine Savings (GS) - for Germany over the period 1850-2000. We find that German sustainability indicators are positive for the most part, although they are negative during and after the two World Wars and also the Great Depression. We also test the relationship between these wealth changes and a number of measures of well-being over the long-run: changes in consumption as well as changes in average height and infant mortality rates. We find a positive relationship between GS and our well-being indicators over different time horizons, however, the relationship breaks down during WWII. We also test if the GS/Comprehensive Wealth framework is able to cope with massive disinvestment at the end of the Second World War due to war-related destructions and dismantlement. We find that negative rates of GS were by and large avoided due to the accumulation of technology and growth-friendly institutions. We demonstrate the importance of broader measures of capital, including measures of technological progress, and its role in the process of economic development; and the limits of conventional measures of investment to understand why future German consumption did not collapse.
Patterns of care and outcomes among triple‐negative early breast cancer patients in South Western Sydney
Authors: Naher Sayeda , Tognela Annette , Moylan Eugene , Adams Diana H. , Kiely Belinda E 
Published: October 2017

AbstractBackgroundTriple‐negative breast cancer (TNBC) represents 12‐24% of all breast cancer and carries a poor prognosis upon recurrence. Little is known of the treatment, or timing and frequency of recurrences outside of a clinical trial.AimWe describe the patterns of care and outcomes of women with TNBC treated at two cancer centres in Sydney, NSW, Australia, to help oncologists talk to women with this subtype of breast cancer about their likely prognosis.MethodsWe searched the electronic medical record for women with stages I–III TNBC diagnosed from 2006 to 2014. For each woman, we recorded demographics, tumour characteristics, treatment details, recurrences and survival using the Kaplan–Meier method.ResultsWe identified 137 women with a median age of 55 years (interquartile range (IQR) 44–63). The median tumour size was 25 mm (IQR 16–35). Most women had grade 3 (92%) and ductal carcinomas (89%), and 35% were node positive; 113 (82%) patients received (neo)adjuvant chemotherapy. The most prescribed regimens for node‐negative tumours were: fluorouracil, epirubicin and cyclophosphamide (FEC) × 6 (23pts, 35%), and for node‐positive tumours, FEC‐Docetaxel (18pts, 40%). Adjuvant radiotherapy was delivered to 114 (83%) patients. After a median follow up of 40 months, 17 patients (12%) had a recurrence. All but one recurrence (94%) occurred within 3 years of diagnosis. Twelve women received palliative chemotherapy, and 14 women have died. The median survival from the time of recurrence was 18 months (IQR 5–26). Seven women (5%) had a documented BRCA1 mutation, and four women (3%) had a documented BRCA2 mutation.ConclusionsTNBC affects women at a relatively young age and tends to recur early. Survival following metastatic disease is short, and more effective therapies are needed.
Effect of combined solifenacin and aclatonium in preventing dry mouth in patients with overactive bladder
Authors: Park Hyoung Keun , Kim Hyeong Gon , Yang Dae Yul , Choi Woo Suk , Paick Sung Hyun , Chung Hong , Yang Sang‐Kuk 
Published: October 2017

ObjectiveThe aim of the present study was to prospectively evaluate the effect of aclatonium on dry mouth in patients with overactive bladder (OAB) after treatment with solifenacin.MethodsA multicenter randomized double‐blind controlled trial was conducted. The study subjects were men and women who had been diagnosed with OAB for ≥3 months and presented with a total Overactive Bladder Symptom Score (OABSS) ≥3. Eligible subjects were randomized to receive 5 mg solifenacin with placebo or 5 mg solifenacin with 150 mg aclatonium once daily for 8 weeks. Subjects rated dry mouth using a visual analog scale (VAS) and completed the OAB‐questionnaire (OAB‐q) short form (SF) and OABSS questionnaires at baseline and after 8 weeks treatment. Dry mouth was defined as a VAS score >30 points (range 0–100).ResultsOverall, 92 patients (49 and 43 in the placebo and aclatonium groups, respectively) completed the 8‐week treatment. In patients who had dry mouth at baseline, no differences were detected in changes in the dry mouth VAS, OABSS, or OAB‐q SF scores between the 2 groups. However, in patients who had no dry mouth at baseline, the change in dry mouth VAS score was significantly lower in the aclatonium‐ than placebo‐treated group: the VAS score increased 20 points in the placebo group compared with 9 points in the aclatonium group (P = .03). However, there were no significant differences in changes in the OABSS and OAB‐q SF scores between the 2 groups.ConclusionsAclatonium decreased dry mouth without disturbing treatment efficacy in patients who did not have dry mouth before treatment.
Excessive UDPG resulting from the mutation of UAP1 causes programmed cell death by triggering reactive oxygen species accumulation and caspase‐like activity in rice
Authors: Xiao Guiqing , Zhou Jiahao , Lu Xiangyang , Huang Rongfeng , Zhang Haiwen 
Published: October 2017

Summary

Lesion mimic mutants are valuable to unravel the mechanisms governing the programmed cell death (PCD) process. Uridine 5′‐diphosphoglucose‐glucose (UDPG) functions as a signaling molecule activating multiple pathways in animals, but little is known about its function in plants.

Two novel allelic mutants of spl29 with typical PCD characters and reduced pollen viability were obtained by ethane methyl sulfonate mutagenesis in rice cv Kitaake.

The enzymatic analyses showed that UDP‐N‐acetylglucosamine pyrophosphorylase 1 (UAP1) irreversibly catalyzed the decomposition of UDPG. Its activity was severely destroyed and caused excessive UDPG accumulation, with the lesion occurrence associated with the enhanced caspase‐like activities in spl29‐2. At the transcriptional level, several key genes involved in endoplasmic reticulum stress and the unfolded protein response were abnormally expressed. Moreover, exogenous UDPG could aggravate lesion initiation and development in spl29‐2. Importantly, exogenous UDPG and its derivative UDP‐N‐acetylglucosamine could induce reactive oxygen species (ROS) accumulation and lesion mimics in Kitaake seedlings.

These results suggest that the excessive accumulation of UDPG, caused by the mutation of UAP1, was a key biochemical event resulting in the lesion mimics in spl29‐2. Thus, our findings revealed that UDPG might be an important component involved in ROS accumulation, PCD execution and lesion mimicking in rice, which also provided new clues for investigating the connection between sugar metabolism and PCD process.
Overhydration, underhydration, and total body sodium: A tricky “ménage a trois” in dialysis patients
Authors: Voroneanu Luminita , Gavrilovici Cristina , Covic Adrian 
Published: October 2017

AbstractOverhydration is a frequent complication in dialysis patients. It has been linked with hypertension, left ventricular hypertrophy, arterial stiffness, atherosclerosis uremic cardiomyopathy, and all‐cause mortality or cardiovascular morbidity. In addition, predialysis underhydration is also associated with increased risk of death in ESRD patients. In this context, the optimal evaluation of hydration status is a must. However, this mission is not easy or accurate. In the last 10 years, several new methods have been tested in dialysis patients, particularly bioimpedance and lung ultrasonography. The precise clinical value of these techniques in the daily care of hemodialysis patients is not obvious yet. Sodium is also an important piece of this puzzle. Salt intake and/or removal of sodium during dialysis are essential determinants of optimal hydration status. Recent studies have revealed that salt and water homeostasis is also dependent of tissue sodium storage—increased in hemodialysis patients. However, the significance of increased sodium tissue storage as a cardiovascular risk factor and the relationship between tissue sodium content and hard CV endpoint have not yet been elucidated yet.
Should Mobile Marketers Collect Data Other Than Geo‐Location?*
Authors: Baye Irina , Sapi Geza 
Published: October 2017

AbstractWe take today's mobile marketing data landscape as a starting point and consider a duopoly model of third‐degree price discrimination in which firms can complement geo‐location information with data on consumer flexibility of varying quality. We show that, depending on consumer heterogeneity, higher‐quality flexibility data affect profits according to three different patterns. In equilibrium, both firms tend to acquire data if the data are of high quality, while only one acquires data if the data quality is low. Firms are likely to gain from additional data if consumers have similar preferences and/or when data are precise. Although social welfare (weakly) improves, consumers can be harmed.