bluuebunny/crossref_metadata_2025_split huggingface dataset:
The solar proxy κ1 Cet and the planetary habitability around the young Sun
Authors: do Nascimento J.-D. , Vidotto A. A. , Petit P. , Folsom C. , de Mello G. F. Porto , Meibom S. , Abrevaya X. C. , Ribas I. , Castro M. , Marsden S. C. , Morin J. , Jeffers S. V. , Guinan E. ,   Bcool Collaboration
Published: September 2017

AbstractAmong the solar proxies, κ1 Cet, stands out as potentially having a mass very close to solar and a young age. We report magnetic field measurements and planetary habitability consequences around this star, a proxy of the young Sun when life arose on Earth. Magnetic strength was determined from spectropolarimetric observations and we reconstruct the large-scale surface magnetic field to derive the magnetic environment, stellar winds, and particle flux permeating the interplanetary medium around κ1 Cet. Our results show a closer magnetosphere and mass-loss rate 50 times larger than the current solar wind mass-loss rate when Life arose on Earth, resulting in a larger interaction via space weather disturbances between the stellar wind and a hypothetical young-Earth analogue, potentially affecting the habitability. Interaction of the wind from the young Sun with the planetary ancient magnetic field may have affected the young Earth and its life conditions.
Anxiety Reduces Empathy Toward Outgroup Members But Not Ingroup Members
Authors: Arceneaux Kevin 
Published: September 2017

AbstractSubstantial research concludes that favoritism toward members of people's ingroup, or ingroup bias, motivates people to oppose public programs that assist needy outgroup individuals. I argue that a gap in the empathic capacity for ingroup and outgroup members motivates and maintains ingroup bias in helping behavior and is sensitive to contextual cues that trigger anxiety. Using a novel experimental design, Study 1 demonstrates that anxiety exacerbates the outgroup empathy gap. Study 2 replicates these findings with an explicit measure of outgroup empathy. Study 3 shows that the outgroup empathy gap causes individuals to become less supportive of helping needy outgroup members. These studies suggest that opposition to welfare programs may go beyond simple prejudice.
Low carbon renewable natural gas production from coalbeds and implications for carbon capture and storage
Authors: Huang Zaixing , Sednek Christine , Urynowicz Michael A. , Guo Hongguang , Wang Qiurong , Fallgren Paul , Jin Song , Jin Yan , Igwe Uche , Li Shengpin 
Published: September 2017

AbstractIsotopic studies have shown that many of the world’s coalbed natural gas plays are secondary biogenic in origin, suggesting a potential for gas regeneration through enhanced microbial activities. The generation of biogas through biostimulation and bioaugmentation is limited to the bioavailability of coal-derived compounds and is considered carbon positive. Here we show that plant-derived carbohydrates can be used as alternative substrates for gas generation by the indigenous coal seam microorganisms. The results suggest that coalbeds can act as natural geobioreactors to produce low carbon renewable natural gas, which can be considered carbon neutral, or perhaps even carbon negative depending on the amount of carbon sequestered within the coal. In addition, coal bioavailability is no longer a limiting factor. This approach has the potential of bridging the gap between fossil fuels and renewable energy by utilizing existing coalbed natural gas infrastructure to produce low carbon renewable natural gas and reducing global warming.
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Authors: Dite Toby A. , Ling Naomi X. Y. , Scott John W. , Hoque Ashfaqul , Galic Sandra , Parker Benjamin L. , Ngoei Kevin R. W. , Langendorf Christopher G. , O’Brien Matthew T. , Kundu Mondira , Viollet Benoit , Steinberg Gregory R. , Sakamoto Kei , Kemp Bruce E. , Oakhill Jonathan S. 
Published: September 2017

AbstractAMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for maintaining cellular energy homeostasis. Activation of AMPK by salicylate and the thienopyridone A-769662 is critically dependent on phosphorylation of Ser108 in the β1 regulatory subunit. Here, we show a possible role for Ser108 phosphorylation in cell cycle regulation and promotion of pro-survival pathways in response to energy stress. We identify the autophagy initiator Unc-51-like kinase 1 (ULK1) as a β1-Ser108 kinase in cells. Cellular β1-Ser108 phosphorylation by ULK1 was dependent on AMPK β-subunit myristoylation, metabolic stress associated with elevated AMP/ATP ratio, and the intrinsic energy sensing capacity of AMPK; features consistent with an AMP-induced myristoyl switch mechanism. We further demonstrate cellular AMPK signaling independent of activation loop Thr172 phosphorylation, providing potential insight into physiological roles for Ser108 phosphorylation. These findings uncover new mechanisms by which AMPK could potentially maintain cellular energy homeostasis independently of Thr172 phosphorylation.
Antisite occupation induced single anionic redox chemistry and structural stabilization of layered sodium chromium sulfide
Authors: Shadike Zulipiya , Zhou Yong-Ning , Chen Lan-Li , Wu Qu , Yue Ji-Li , Zhang Nian , Yang Xiao-Qing , Gu Lin , Liu Xiao-Song , Shi Si-Qi , Fu Zheng-Wen 
Published: September 2017

AbstractThe intercalation compounds with various electrochemically active or inactive elements in the layered structure have been the subject of increasing interest due to their high capacities, good reversibility, simple structures, and ease of synthesis. However, their reversible intercalation/deintercalation redox chemistries in previous compounds involve a single cationic redox reaction or a cumulative cationic and anionic redox reaction. Here we report an anionic redox chemistry and structural stabilization of layered sodium chromium sulfide. It was discovered that the sulfur in sodium chromium sulfide is electrochemically active, undergoing oxidation/reduction rather than chromium. Significantly, sodium ions can successfully move out and into without changing its lattice parameter c, which is explained in terms of the occurrence of chromium/sodium vacancy antisite during desodiation and sodiation processes. Our present work not only enriches the electrochemistry of layered intercalation compounds, but also extends the scope of investigation on high-capacity electrodes.
Electrically driven single-photon emission from an isolated single molecule
Authors: Zhang Li , Yu Yun-Jie , Chen Liu-Guo , Luo Yang , Yang Ben , Kong Fan-Fang , Chen Gong , Zhang Yang , Zhang Qiang , Luo Yi , Yang Jin-Long , Dong Zhen-Chao , Hou J. G. 
Published: September 2017

AbstractElectrically driven molecular light emitters are considered to be one of the promising candidates as single-photon sources. However, it is yet to be demonstrated that electrically driven single-photon emission can indeed be generated from an isolated single molecule notwithstanding fluorescence quenching and technical challenges. Here, we report such electrically driven single-photon emission from a well-defined single molecule located inside a precisely controlled nanocavity in a scanning tunneling microscope. The effective quenching suppression and nanocavity plasmonic enhancement allow us to achieve intense and stable single-molecule electroluminescence. Second-order photon correlation measurements reveal an evident photon antibunching dip with the single-photon purity down to g(2)(0) = 0.09, unambiguously confirming the single-photon emission nature of the single-molecule electroluminescence. Furthermore, we demonstrate an ultrahigh-density array of identical single-photon emitters.
Understanding the factors affecting self-management of COPD from the perspectives of healthcare practitioners: a qualitative study
Authors: Ogunbayo Oladapo J. , Russell Sian , Newham James J. , Heslop-Marshall Karen , Netts Paul , Hanratty Barbara , Kaner Eileen 
Published: September 2017

AbstractSelf-management is recognised as an essential criteria for the provision of high quality care for chronic obstructive pulmonary disease (COPD). The management of COPD is usually delivered by a wide range of healthcare practitioners. This study aimed to understand the factors affecting self-management of COPD from the perspectives of the different multidisciplinary healthcare teams involved in COPD care. Semi-structured interviews were conducted with participants from primary care, specialist respiratory and pulmonary rehabilitation (PR) teams. Purposive sampling and snowballing were employed in participant recruitment. All interviews were audio-recorded and transcribed verbatim and data were analysed thematically. A total of 20 participants (eight primary care practitioners, seven respiratory specialists and five PR practitioners) were interviewed until data saturation was reached. Participants identified a range of complex and interrelated factors affecting COPD self-management that were grouped into three broad categories—patient, practitioner and organisational/system-level factors. Patient-level factors were predominantly considered as barriers, with COPD knowledge and understanding, and the individual patients’ life circumstances/context being the most prominent issues. Practitioner-level factors identified were practitioners’ speciality, interest and experience in respiratory conditions as the overarching factor that influenced how self-management was understood and practiced. A number of organisational/system-level factors were identified by all practitioners, including inconsistency of referral pathways and the wide variations of different self-management planning tools. Factors affecting self-management of COPD across these three levels need to be tackled equally in order to improve the effectiveness of interventions and to embed and integrate self-management support approaches into routine practice.
Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
Authors: Fournier M. , Monin A. , Ferrari C. , Baumann P. S. , Conus P. , Do K. 
Published: September 2017

AbstractxCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress and glutamatergic neurotransmission. But data from human studies implicating xCT in the illness and clarifying the upstream mechanisms of xCT imbalance are still scarce. Low glutathione (GSH) levels and genetic risk in GCLC (Glutamate–Cysteine Ligase Catalytic subunit), the gene of limiting synthesizing enzyme for GSH, are both associated with schizophrenia. In the present study, we aimed at determining if xCT regulation by the redox system is involved in schizophrenia pathophysiology. We assessed whether modulating GCLC expression impact on xCT expression and activity (i) in fibroblasts from patients and controls with different GCLC genotypes which are known to affect GCLC regulation and GSH levels; (ii) in rat brain glial cells, i.e., astrocytes and oligodendrocytes, with a knock-down of GCLC. Our results highlight that decreased GCLC expression leads to an upregulation of xCT levels in patients’ fibroblasts as well as in astrocytes. These results support the implication of xCT dysregulation in illness pathophysiology and further indicate that it can result from redox changes. Additionally, we showed that these anomalies may already take place at early stages of psychosis and be more prominent in a subgroup of patients with GCLC high-risk genotypes. These data add to the existing evidence identifying the inflammatory/redox systems as important targets to treat schizophrenia already at early stages.
Primary and secondary non-adherence to osteoporotic medications after hip fracture in Spain. The PREV2FO population-based retrospective cohort study
Authors: García-Sempere Aníbal , Hurtado Isabel , Sanfélix-Genovés José , Rodríguez-Bernal Clara L. , Gil Orozco Rafael , Peiró Salvador , Sanfélix-Gimeno Gabriel 
Published: September 2017

AbstractOsteoporotic medication after hip fracture is widely recommended by clinical practice guidelines, and medication adherence is essential to meet clinical trial risk reduction figures in the real world. We assessed primary and secondary non-adherence to osteoporosis medications in patients discharged following a hip fracture and identified factors associated with secondary non-adherence. From a population-based retrospective cohort of 19,405 patients aged 65 years and over discharged from a hip fracture in the region of Valencia (Spain) from January 1, 2008 and June 30, 2012, we followed, over a minimum of 365 days, 4,856 patients with at least one osteoporotic medication prescribed within the first six months after discharge. Less than one third of the patients discharged alive after a hip fracture received osteoporotic treatment. Primary non-adherence among naïve patients was low. However, long-term secondary adherence measured by Proportion of Days Covered with medication (PDC) and persistence was largely suboptimal, with naïve users having worse results than experienced patients. Secondary non-adherence was associated with primary non-adherence and age, dementia or sedative treatments for naïve users and with being male, being older than 85 and having dementia for experienced users. Three quarters of naïve users and two thirds of experienced users had interrupted treatment at 48 months.
Magnetic Tunnel Junction as an On-Chip Temperature Sensor
Authors: Sengupta Abhronil , Liyanagedera Chamika Mihiranga , Jung Byunghoo , Roy Kaushik 
Published: September 2017

AbstractTemperature sensors are becoming an increasingly important component in System-on-Chip (SoC) designs with increasing transistor scaling, power density and associated heating effects. This work explores a compact nanoelectronic temperature sensor based on a Magnetic Tunnel Junction (MTJ) structure. The MTJ switches probabilistically depending on the operating temperature in the presence of thermal noise. Performance evaluation of the proposed MTJ temperature sensor, based on experimentally measured device parameters, reveals that the sensor is able to achieve a conversion rate of 2.5K samples/s with energy consumption of 8.8 nJ per conversion (1–2 orders of magnitude lower than state-of-the-art CMOS sensors) for a linear sensing regime of 200–400 K.
An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy
Authors: Dixon Peter H. , Sambrotta Melissa , Chambers Jennifer , Taylor-Harris Pamela , Syngelaki Argyro , Nicolaides Kypros , Knisely A. S. , Thompson Richard J. , Williamson Catherine 
Published: September 2017

AbstractIntrahepatic cholestasis of pregnancy (ICP) affects 1/140 UK pregnancies; with pruritus, hepatic impairment and elevated serum bile acids. Severe disease is complicated by spontaneous preterm delivery and stillbirth. Previous studies have reported mutations in hepatocellular transporters (ABCB4, ABCB11). High throughput sequencing in 147 patients was performed in the transporters ABCB4, ABCB11, ATP8B1, ABCC2 and tight junction protein 2 (TJP2). Twenty-six potentially damaging variants were identified with the following predicted protein changes: Twelve ABCB4 mutations - Arg47Gln, Met113Val, Glu161Gly, Thr175Ala, Glu528Glyfs*6, Arg590Gln, Ala601Ser, Glu884Ter, Gly722Ala, Tyr775Met (x2), Trp854Ter. Four potential ABCB11 mutations - Glu297Gly (x3) and a donor splice site mutation (intron 19). Five potential ATP8B1 mutations - Asn45Thr (x3), and two others, Glu114Gln and Lys203Glu. Two ABCC2 mutations - Glu1352Ala and a duplication (exons 24 and 25). Three potential mutations were identified in TJP2; Thr62Met (x2) and Thr626Ser. No patient harboured more than one mutation. All were heterozygous. An additional 545 cases were screened for the potential recurrent mutations of ATP8B1 (Asn45Thr) and TJP2 (Thr62Met) identifying three further occurrences of Asn45Thr. This study has expanded known mutations in ABCB4 and ABCB11 and identified roles in ICP for mutations in ATP8B1 and ABCC2. Possible novel mutations in TJP2 were also discovered.
An alternate mode of oligomerization for E. coli SecA
Authors: Yazdi Aliakbar Khalili , Vezina Grant C. , Shilton Brian H. 
Published: September 2017

AbstractSecA is the ATPase of preprotein translocase. SecA is a dimer in solution and changes in its oligomeric state may function in preprotein translocation. The SecA-N68 construct, in which the C-terminal helical domains of SecA are deleted, was used to investigate the mechanism of SecA oligomerization. SecA-N68 is in equilibrium between monomers, dimers, and tetramers. Subunit interactions in the SecA-N68 tetramer are mediated entirely by unstructured regions at its N- and C-termini: when the termini are deleted to yield SecA-N68∆NC, the construct is completely monomeric. This monomeric construct yielded crystals diffracting to 2.6 Å that were used to solve the structure of SecA-N68, including the “preprotein crosslinking domain” (PPXD) that was missing from previous E. coli SecA structures. The SecA-N68 structure was combined with small angle X-ray scattering (SAXS) data to construct a model of the SecA-N68 tetramer that is consistent with the essential roles of the extreme N- and C-termini in oligomerization. This mode of oligomerization, which depends on binding of the extreme N-terminus to the DEAD motor domains, NBD1 and NBD2, was used to model a novel parallel and flexible SecA solution dimer that agrees well with SAXS data.
Analyzing the Quantum Zeno and anti-Zeno effects using optimal projective measurements
Authors: Aftab Muhammad Junaid , Chaudhry Adam Zaman 
Published: September 2017

AbstractMeasurements in quantum mechanics can not only effectively freeze the quantum system (the quantum Zeno effect) but also accelerate the time evolution of the system (the quantum anti-Zeno effect). In studies of these effects, a quantum state is prepared repeatedly by projecting the quantum state onto the initial state. In this paper, we repeatedly prepare the initial quantum state in a different manner. Instead of only performing projective measurements, we allow unitary operations to be performed, on a very short time-scale, after each measurement. We can then repeatedly prepare the initial state by performing some projective measurement and then, after each measurement, we perform a suitable unitary operation to end up with the same initial state as before. Our objective is to find the projective measurements that minimize the effective decay rate of the quantum state. We find such optimal measurements and the corresponding decay rates for a variety of system-environment models such as the pure dephasing model and the spin-boson model. We find that there can be considerable differences between this optimized effective decay rate and the usual decay rate obtained by repeatedly projecting onto the initial state. In particular, the Zeno and anti-Zeno regimes can be considerably modified.
In vivo mouse and live cell STED microscopy of neuronal actin plasticity using far-red emitting fluorescent proteins
Authors: Wegner Waja , Ilgen Peter , Gregor Carola , van Dort Joris , Mott Alexander C. , Steffens Heinz , Willig Katrin I. 
Published: September 2017

AbstractThe study of proteins in dendritic processes within the living brain is mainly hampered by the diffraction limit of light. STED microscopy is so far the only far-field light microscopy technique to overcome the diffraction limit and resolve dendritic spine plasticity at superresolution (nanoscopy) in the living mouse. After having tested several far-red fluorescent proteins in cell culture we report here STED microscopy of the far-red fluorescent protein mNeptune2, which showed best results for our application to superresolve actin filaments at a resolution of ~80 nm, and to observe morphological changes of actin in the cortex of a living mouse. We illustrate in vivo far-red neuronal actin imaging in the living mouse brain with superresolution for time periods of up to one hour. Actin was visualized by fusing mNeptune2 to the actin labels Lifeact or Actin-Chromobody. We evaluated the concentration dependent influence of both actin labels on the appearance of dendritic spines; spine number was significantly reduced at high expression levels whereas spine morphology was normal at low expression.
Global transcriptome analysis and identification of genes involved in nutrients accumulation during seed development of rice tartary buckwheat (Fagopyrum Tararicum)
Authors: Huang Juan , Deng Jiao , Shi Taoxiong , Chen Qijiao , Liang Chenggang , Meng Ziye , Zhu Liwei , Wang Yan , Zhao Fengli , Yu Shizhou , Chen Qingfu 
Published: September 2017

AbstractTartary buckwheat seeds are rich in various nutrients, such as storage proteins, starch, and flavonoids. To get a good knowledge of the transcriptome dynamics and gene regulatory mechanism during the process of seed development and nutrients accumulation, we performed a comprehensive global transcriptome analysis using rice tartary buckwheat seeds at different development stages, namely pre-filling stage, filling stage, and mature stage. 24 819 expressed genes, including 108 specifically expressed genes, and 11 676 differentially expressed genes (DEGs) were identified. qRT-PCR analysis was performed on 34 DEGs to validate the transcriptome data, and a good consistence was obtained. Based on their expression patterns, the identified DEGs were classified to eight clusters, and the enriched GO items in each cluster were analyzed. In addition, 633 DEGs related to plant hormones were identified. Furthermore, genes in the biosynthesis pathway of nutrients accumulation were analyzed, including 10, 20, and 23 DEGs corresponding to the biosynthesis of seed storage proteins, flavonoids, and starch, respectively. This is the first transcriptome analysis during seed development of tartary buckwheat. It would provide us a comprehensive understanding of the complex transcriptome dynamics during seed development and gene regulatory mechanism of nutrients accumulation.
Investigation of the inhibition effect and mechanism of myricetin to Suilysin by molecular modeling
Authors: Niu Xiaodi , Sun Lin , Wang Guizhen , Gao Yawen , Yang Yanan , Wang Xiyan , Wang Hongsu 
Published: September 2017

AbstractIn the present study, the inhibitory effect and mechanism of myricetin, a natural flavonoid compound, in relation to Suilysin (SLY) were investigated through molecular dynamics simulations, mutational analysis and fluorescence-quenching assays. Myricetin is a potential inhibitor that does not exhibit antimicrobial activity but has been shown to inhibit SLY cytotoxicity. Molecular dynamics simulations and mutational analysis revealed that myricetin binds directly to SLY in the gap between domains 2 and 3, an important region for oligomerization and pore formation. The results of principal component analysis (PCA) indicated that the binding of myricetin in this gap region restricts the conformational transition of SLY from a monomer to an oligomer, thereby counteracting the haemolytic activity of SLY. This mechanism was verified using a haemolysis assay. These results demonstrated that myricetin is a strong candidate as a novel therapeutic agent for the treatment of Streptococcus suis infections.