bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes – AGES-Reykjavik Study
Authors: Imai Cindy M. , Halldorsson Thorhallur I. , Eiriksdottir Gudny , Cotch Mary F. , Steingrimsdottir Laufey , Thorsdottir Inga , Launer Lenore J. , Harris Tamara , Gudnason Vilmundur , Gunnarsdottir Ingibjorg 
Published: November 2015

AbstractLow vitamin D status may be associated with depression. Few studies have examined vitamin D and depression in older adults living at northern latitudes. The present study cross-sectionally investigated serum 25-hydroxyvitamin D (25(OH)D) status and depression among 5006 community-dwelling older persons (66–96 years) living in Iceland (latitudes 64–66°N). Depressive symptoms were measured by the fifteen-item Geriatric Depression Scale (GDS-15). Current major depressive disorder was assessed according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Serum 25(OH)D was analysed using chemiluminescence immunoassay and categorised into three groups: deficient (<30 nmol/l); inadequate (30–49·9 nmol/l); and adequate (≥50 nmol/l). There were twenty-eight (2 %) men and fifty (1 %) women with current major depressive disorder. Mean GDS-15 scores for men and women with adequate vitamin D concentrations were 2·1 and 2·2, respectively. Men and women with deficientv.adequate vitamin D status had more depressive symptoms (higher GDS-15 scores) (difference 0·7 (95 % CI 0·4, 0·9) and 0·4 (95 % CI 0·1, 0·6), respectively). Furthermore, men with deficient vitamin D status were more likely to have current major depressive disorder (adjusted OR 2·51; 95 % CI 1·03, 6·13) compared with men with adequate vitamin D status. Associations among women were not significant. In this older population living at northern latitudes, deficient vitamin D status may be associated with depression. Further investigations are warranted to evaluate the pathways that may be associated with risk of depression among older adults.
Relocation of nucleolar fibrillarin in Trypanosoma cruzi during stationary phase
Authors: GUERRERO-SÁNCHEZ ERNESTO , CEVALLOS ANA MARÍA , MARTÍNEZ-CALVILLO SANTIAGO , LÓPEZ-VILLASEÑOR IMELDA , HERNÁNDEZ ROBERTO 
Published: November 2015

SUMMARYTrypanosoma cruziis the aetiological agent of Chagas disease. Our group has focused on the study of ribosomal RNA and nucleolar structure in this organism. In this work, we address the cellular location of fibrillarin in epimastigotes. As a conserved and unreported feature in trypanosomatids, fibrillarin inT. cruziis encoded by two genes that differ by approximately 35% in their deduced amino acid sequences (TcFib 1 and TcFib 2). Chimaeric fluorescent versions ofTcFib1andTcFib2were individually expressed inT. cruzicells. Both transfected cultures showed cells with a nucleolar fluorescent signal. We have not found any evident distinction between the structure or expression of Tcfibrillarins to propose a functional difference in cells. With the aid of an anti-TcFib 2 antibody, it was found that the endogenous protein relocates outside of the nucleolus in stationary epimastigotes. This was also the case in metacyclic trypomastigotes observed from aged cultures. The significance of this observation is not known, but a deficiency of fibrillarin nucleolar retention correlates with the observed reduction in the abundance of the pre-ribosomal RNAs species at stationary phase, and suggests that the nucleolar location of this protein depends on physiological processes.
Microsatellite markers for Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) and other Cryptolestes species
Authors: Wu Y. , Li F. , Li Z. , Stejskal V. , Kučerová Z. , Opit G. , Aulicky R. , Zhang T. , He P. , Cao Y. 
Published: November 2015

AbstractCryptolestes ferrugineus (Stephens, 1831) is an important insect pest of stored products. Due to its broad host range, short life cycle, and high reproductive capacity, this species has rapidly colonized temperate and tropical regions around the world. In this study, we isolated 18 novel polymorphic microsatellite loci from an enriched genomic library based on a biotin/streptavidin capture protocol. These loci will be useful tool to better understand the genetic structure and migration patterns of C. ferrugineus throughout the world. The genetic parameters were estimated based on 80 individual C. ferrugineus from two natural populations. The results revealed that 18 loci were different polymorphic levels. The numbers of alleles ranged from 3 to 12, and eleven loci demonstrated polymorphic information contents greater than 0.5. The observed (HO) and expected (HE) heterozygosities ranged from 0.051 to 0.883 and 0.173 to 0.815, respectively. Five locus/population combinations significantly deviated from Hardy–Weinberg equilibrium. We also demonstrated the potential utility of the C. ferrugineus microsatellites as population and species markers for four additional Cryptolestes species.
Pure Injective and Absolutely Pure Sheaves
Authors: Enochs Edgar , Estrada Sergio , Odabaşi Sinem 
Published: November 2015

AbstractWe study two notions of purity in categories of sheaves: the categorical and the geometric. It is shown that pure injective envelopes exist in both cases under very general assumptions on the scheme. Finally, we introduce the class of locally absolutely pure (quasi-coherent) sheaves with respect to the geometrical purity, and characterize locally Noetherian closed subschemes of a projective scheme in terms of the new class.
DETERMINANTS OF FERTILIZER MICRODOSING-INDUCED YIELD INCREMENT OF PEARL MILLET ON AN ACID SANDY SOIL
Authors: IBRAHIM ALI , ABAIDOO ROBERT CLEMENT , FATONDJI DOUGBEDJI , OPOKU ANDREWS 
Published: November 2015

SUMMARYRecent studies have reported the benefits of fertilizer microdosing in increasing crop yields in low input cropping systems. Little information is however available on the mechanisms underlying this effect. The objective of this study was therefore to explore the root-based mechanisms governing the growth enhancing phenomena of the fertilizer microdosing technology. A two-year experiment was conducted at the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Research Station in Niger. Four treatments comprising (i) 2 g hill−1of diammonuim phosphate (DAP), (ii) 6 g hill−1of compound fertilizer NPK, (iii) broadcasting of 200 kg ha−1of compound fertilizer NPK (recommended rate) and (iv) unfertilized control was arranged in a randomized complete block design with four replications. On average, fertilizer microdosing treatments (2-g DAP hill−1and 6-g NPK hill−1) achieved 86% and 79% of the grain yields recorded from broadcasting of 200-kg NPK ha−1, respectively, in 2013 and 2014. The leaf area index and leaf chlorophyll content significantly increased with fertilizer microdosing at the early stage of millet growth. At the same stage, fertilizer microdosing enhanced the lateral root length density in the topsoil (0–20 cm) by 72% and 40% at respective lateral distances of 25 cm and 50 cm from the centre of the hill compared with broadcast of 200-kg NPK ha−1. Fertilizer microdosing did not significantly change soil pH in the root zone. It is concluded that the positive effect of fertilizer microdosing in increasing millet yield results from the better exploitation of soil nutrients due to early lateral roots proliferation within the topsoil.
Top-cited articles of the last 30 years (1985–2014) in otolaryngology – head and neck surgery
Authors: Lenzi R , Fortunato S , Muscatello L 
Published: November 2015

AbstractBackground:The frequency with which a scientific article is cited by other studies is one way to measure its academic influence.Methods:A comprehensive search was performed to identify journal articles in the otorhinolaryngology subject category of the 2013 Journal Citation Report Science Edition over the last 30 years (1985–2014). The 100 most cited articles were reviewed and basic information including the publication year, country of origin, source journal, article type and research field was collected.Results:The 100 most cited articles were published in 15 of the 44 otorhinolaryngology journals. The number of citations per article ranged between 208 and 1559. The leading research field was otology and neurotology (n = 50), followed by rhinology (n = 23) and head and neck surgery (n = 11). Most papers originated in the USA (n = 64).Conclusion:The possibility of an article being cited is influenced by the publication language, country of origin and source journal.
‘Self-Help which Ennobles a Nation’: Development, citizenship, and the obligations of eating in India's austerity years
Authors: SIEGEL BENJAMIN 
Published: November 2015

AbstractIn the years immediately following independence, India's political leadership, assisted by a network of civic organizations, sought to transform what, how, and how much Indians ate. These campaigns, this article argues, embodied a broader post-colonial project to reimagine the terms of citizenship and development in a new nation facing enduring scarcity. Drawing upon wartime antecedent, global ideologies of population and land management, and an ethos of austerity imbued with the power to actualize economic self-reliance, the new state urged its citizens to give up rice and wheat, whose imports sapped the nation of the foreign currency needed for industrial development. In place of these staples, India's new citizens were asked to adopt ‘substitute’ and ‘subsidiary’ foods—including bananas, groundnuts, tapioca, yams, beets, and carrots—and give up a meal or more each week to conserve India's scant grain reserves. And as Indian planners awaited the possibility of fundamental agricultural advance and agrarian reform, they looked to food technology and the promise of ‘artificial rice’ as a means of making up for India's perennial food deficit. India's women, as anchors of the household—and therefore, the nation—were tasked with facilitating these dietary transformations, and were saddled with the blame when these modernist projects failed. Unable to marshal the resources needed to undertake fundamental agricultural reform, India's planners placed greater faith in their ability to exercise authority over certain aspects of Indian citizenship itself, tying the remaking of practices and sentiments to the reconstruction of a self-reliant national economy.
Earthquakes in Japan
Authors: HUNTER JANET 
Published: November 2015

AbstractThis review article examines three monographs that make conspicuous contributions to our understanding of major earthquake disasters in Japan from the mid-nineteenth century through to 2011. They focus on different events and different time periods, and ask different questions, but raise a host of shared issues relating to the on-going importance of disaster in Japan's history over the long term. They cause us to consider how seismic disaster is explained, understood, interpreted, and actualized in people's lives, how the risks are factored in, and how people respond to both immediate crisis and longer term consequences. One recurrent issue in these volumes is the extent to which these large natural disasters have the capacity to change—and actually do change—the ways in which societies organize themselves. In some cases disaster may be perceived as opportunity, but the evidence overwhelmingly suggests that a desire to return to the previous ‘normality’ is a powerful impulse in people's responses to major natural disasters. The review also argues that the issue of trust lies at the core of both individual and collective responses. A lack of trust may be most conspicuous in attitudes to government and elites, but is also inherent in more everyday personal interactions and market transactions in the immediate aftermath of disaster.
Diversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites
Authors: TEMPLETON THOMAS J. , PAIN ARNAB 
Published: November 2015

SUMMARYThe recent completion of high-coverage draft genome sequences for several alveolate protozoans – namely, the chromerids,Chromera veliaandVitrella brassicaformis; the perkinsidPerkinsus marinus; the apicomplexan,Gregarina niphandrodes, as well as high coverage transcriptome sequence information for several colpodellids, allows for new genome-scale comparisons across a rich landscape of apicomplexans and other alveolates. Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell–cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate – guided by ultrastructure, life strategies and phylogenetic relationships – in an attempt to understand the evolution of obligate parasitism in apicomplexans.
A novel planar parallel manipulator with high orientation capability for a hybrid machine tool: kinematics, dimensional synthesis and performance evaluation
Authors: Assal Samy F. M. 
Published: November 2015

SUMMARYIn order to potentially realize the advantages of planar parallel manipulators to be used for hybrid machine tools, the inherently abundant singularities which diminish the usable workspace must be eliminated. Proper structure synthesis and dimensional synthesis can provide a good solution. So, a non-conventional architecture of a three-PPR planar parallel manipulator is proposed in this paper for a hybrid machine tool. The proposed architecture permits a large dexterous workspace with unlimited orientation capability and no singularities. It also provides partially decoupled motion which permits independent actuators control. The kinematic, singularity, orientation capability and workspace analyses of the proposed manipulator are studied to verify those advantages. Based on a non-dimensional design parameter space, the highly important indices for this application namely the workspace index (WI), the motion/force transmission index, the kinematic and dynamic dexterity indices and the stiffness index are selected to be maximized yielding proper dimensions of the design parameters. Those performance indices are proven to be uniform over all the workspace achieving highly important characteristics of uniform accuracy, acceleration characteristics, rigidity and force transmissibility. Performance evaluation is finally presented to verify the high performance of the proposed non-singular planar parallel manipulator with high orientation capability.
WHY BEHAVIOURAL POLICY NEEDS MECHANISTIC EVIDENCE
Authors: Grüne-Yanoff Till 
Published: November 2015

Abstract:Proponents of behavioural policies seek to justify them as ‘evidence-based’. Yet they typically fail to show through which mechanisms these policies operate. This paper shows – at the hand of examples from economics and psychology – that without sufficient mechanistic evidence, one often cannot determine whether a given policy in its target environment will be effective, robust, persistent or welfare-improving. Because these properties are important for justification, policies that lack sufficient support from mechanistic evidence should not be called ‘evidence-based’.
DECISION-MAKING ALIGNED WITH RAPID-CYCLE EVALUATION IN HEALTH CARE
Authors: Schneeweiss Sebastian , Shrank William H. , Ruhl Michael , Maclure Malcolm 
Published: November 2015

Background: Availability of real-time electronic healthcare data provides new opportunities for rapid-cycle evaluation (RCE) of health technologies, including healthcare delivery and payment programs. We aim to align decision-making processes with stages of RCE to optimize the usefulness and impact of rapid results. Rational decisions about program adoption depend on program effect size in relation to externalities, including implementation cost, sustainability, and likelihood of broad adoption.Methods: Drawing on case studies and experience from drug safety monitoring, we examine how decision makers have used scientific evidence on complex interventions in the past. We clarify how RCE alters the nature of policy decisions; develop the RAPID framework for synchronizing decision-maker activities with stages of RCE; and provide guidelines on evidence thresholds for incremental decision-making.Results: In contrast to traditional evaluations, RCE provides early evidence on effectiveness and facilitates a stepped approach to decision making in expectation of future regularly updated evidence. RCE allows for identification of trends in adjusted effect size. It supports adapting a program in midstream in response to interim findings, or adapting the evaluation strategy to identify true improvements earlier. The 5-step RAPID approach that utilizes the cumulating evidence of program effectiveness over time could increase policy-makers' confidence in expediting decisions.Conclusions: RCE enables a step-wise approach to HTA decision-making, based on gradually emerging evidence, reducing delays in decision-making processes after traditional one-time evaluations.
Geographic, environmental and biotic sources of variation in the nutrient relations of tropical montane forests
Authors: Dalling James W. , Heineman Katherine , González Grizelle , Ostertag Rebecca 
Published: November 2015

Abstract:Tropical montane forests (TMF) are associated with a widely observed suite of characteristics encompassing forest structure, plant traits and biogeochemistry. With respect to nutrient relations, montane forests are characterized by slow decomposition of organic matter, high investment in below-ground biomass and poor litter quality, relative to tropical lowland forests. However, within TMF there is considerable variation in substrate age, parent material, disturbance and species composition. Here we emphasize that many TMFs are likely to be co-limited by multiple nutrients, and that feedback among soil properties, species traits, microbial communities and environmental conditions drive forest productivity and soil carbon storage. To date, studies of the biogeochemistry of montane forests have been restricted to a few, mostly neotropical, sites and focused mainly on trees while ignoring mycorrhizas, epiphytes and microbial community structure. Incorporating the geographic, environmental and biotic variability in TMF will lead to a greater recognition of plant–soil feedbacks that are critical to understanding constraints on productivity, both under present conditions and under future climate, nitrogen-deposition and land-use scenarios.
A prevalence study ofSalmonellaspp.,Yersiniaspp.,Toxoplasma gondiiand porcine reproductive and respiratory syndrome virus in UK pigs at slaughter
Authors: POWELL L. F. , CHENEY T. E. A. , WILLIAMSON S. , GUY E. , SMITH R. P. , DAVIES R. H. 
Published: November 2015

SUMMARYAn abattoir-based study was undertaken between January and May 2013 to estimate the prevalence ofSalmonellaspp. andYersiniaspp. carriage and seroprevalence of antibodies toToxoplasma gondii andporcine reproductive and respiratory syndrome virus (PRRSv) in UK pigs at slaughter. In total, 626 pigs were sampled at 14 abattoirs that together process 80% of the annual UK pig slaughter throughput. Sampling was weighted by abattoir throughput and sampling dates and pig carcasses were randomly selected. Rectal swabs, blood samples, carcass swabs and the whole caecum, tonsils, heart and tongue were collected.Salmonellaspp. was isolated from 30·5% [95% confidence interval (CI) 26·5–34·6] of caecal content samples but only 9·6% (95% CI 7·3–11·9) of carcass swabs, which was significantly lower than in a UK survey in 2006–2007.S.Typhimurium andS.4,[5],12:i:- were the most commonly isolated serovars, followed byS.Derby andS.Bovismorbificans. The prevalence ofYersinia enterocoliticacarriage in tonsils was 28·7% (95% CI 24·8–32·7) whereas carcass contamination was much lower at 1·8% (95% CI 0·7–2·8). The seroprevalence of antibodies toToxoplasma gondiiand PRRSv was 7·4% (95% CI 5·3–9·5) and 58·3% (95% CI 53·1–63·4), respectively. This study provides a comparison to previous abattoir-based prevalence surveys forSalmonellaandYersinia, and the first UK-wide seroprevalence estimates for antibodies toToxoplasmaand PRRSv in pigs at slaughter.
Assortative mixing as a source of bias in epidemiological studies of sexually transmitted infections: the case of smoking and human papillomavirus
Authors: LEMIEUX-MELLOUKI P. , DROLET M. , BRISSON J. , FRANCO E. L. , BOILY M.-C. , BAUSSANO I. , BRISSON M. 
Published: November 2015

SUMMARYFor studies examining risk factors of sexually transmitted infections (STIs), confounding can stem from characteristics of partners of study subjects, and persist after adjustment for the subjects’ individual-level characteristics. Two conditions that can result in confounding by the subjects’ partners are: (C1) partner choice is assortative by the risk factor examined and, (C2) sexual activity is associated with the risk factor. The objective of this paper is to illustrate the potential impact of the assortativity bias in studies examining STI risk factors, using smoking and human papillomavirus (HPV) as an example. We developed an HPV transmission-dynamic mathematical model in which we nested a cross-sectional study assessing the smoking–HPV association. In our base case, we assumed (1) no effect of smoking on HPV, and (2) conditions C1–C2 hold for smoking (based on empirical data). The assortativity bias caused an overestimation of the odds ratio (OR) in the simulated study after perfect adjustment for the subjects’ individual-level characteristics (adjusted OR 1·51 instead of 1·00). The bias was amplified by a lower basic reproductive number (R0), greater mixing assortativity and stronger association of smoking with sexual activity. Adjustment for characteristics of partners is needed to mitigate assortativity bias.
Assessing urban fortunes in six late medieval ports: an archaeological application of assemblage theory
Authors: JERVIS BEN 
Published: November 2015

ABSTRACT:Variations in the fortunes of six late medieval ports in Sussex are considered using data derived from archaeological excavations. Several indicators are used to assess differences in urban fortunes and to critique the concept of urban ‘decline’. The interpretive framework of assemblage theory is then used to examine why the fortunes of these ports varied. The article argues for a turn from discussions of decay and decline towards considerations of changes, continuities and transformations in urban life in late medieval England.