Abstract 698: Functional outcome and socio-psychological problems for bone & soft tissue sarcoma patients in childhood & AYA generation
Authors: Honoki Kanya , Shinomiya Toshiaki , Fujii Hiromasa , Ishihara Takashi , Tsukamoto Shinji , Kishi Shingo , Kondo Yumiko , Kido Akira , Tsujiuchi Toshifumi , Shima Midori , Tanaka Yasuhito 
Published: July 2017

Abstract
[Objective] To elucidate the problems between functional and sociological outcomes in patients of bone and soft tissue sarcomas in childhood and adolescent/young adult (AYA) generation.
[Method] Clinical (prognostic and functional) and socio-psychological outcomes were retrospectively analyzed in 50 patients with bone and soft tissue sarcomas under 29 years old treated in our institute from 1998 to 2014.
[Results] Twenty-two patients under 15 and 28 of AYA generation (15 to 29 years old) (28 male and 22 female) were subjected, including 35 cases of bone and 15 cases of soft tissue sarcomas, and 39 of extremity cases. Most common diagnosis was osteosarcoma of 27 cases. Limb-sparing surgery was performed in 30 cases, including 14 of prosthetic and 8 of biological reconstruction for bone tumors. Overall Survival rates were 79% for 2 year and 61% for 5 year follow-up periods. 70% of the patients experienced limited activities; 50% in high school and college students experienced drop-out or delay, suspension and repeating the same class; 56% faced to their job lost or limitation of job search; 20% experienced changes of relationship with families and partners (Table). Most taken palliative care intervention was the counseling for family members and caregivers, besides pain management and psychological care. Correlation coefficient failed to show a significant correlation between functional score and sociological disability score both in all limb sparing cases (R2 = 0.2664) and in osteosarcoma cases ((R2 = 0.1757) .
[Conclusion] The sociological problems for patients in this particular group could be focused on school life, job search and relationship with families and partners. QOL is a multidimensional measure with various domains, such as physical, psychological, social well-being, spiritual health as well as functional ability, therefore, multi-disciplinary care for socio-physiological and psychological disadvantage must be taken for this group of patients at earliest convenience.
Reletionship between physiological and socio-psychological problemsSubjectAll patientsLimb-spared patinetsLimitation of activities70% (30/43)75% (21/28)School dropout/delay in high-schoolers & college students50% (14/28)32% (8/25)Lost jobs/job search difficulties56% (9/16)33% (3/9)Changing social reletions with families & partners20% (8/40)21% (3/28)
Citation Format: Kanya Honoki, Toshiaki Shinomiya, Hiromasa Fujii, Takashi Ishihara, Shinji Tsukamoto, Shingo Kishi, Yumiko Kondo, Akira Kido, Toshifumi Tsujiuchi, Midori Shima, Yasuhito Tanaka. Functional outcome and socio-psychological problems for bone & soft tissue sarcoma patients in childhood & AYA generation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 698. doi:10.1158/1538-7445.AM2017-698