bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Versatile Liquid Chromatographic Method for the Simultaneous Determination of Metformin, Sitagliptin, Simvastatin, and Ezetimibe in Different Dosage Forms
Authors: El-Zaher Asmaa A , Elkady Ehab F , Elwy Hanan M , Saleh Mahmoud Abo El Makarim 
Published: July 2017

Abstract
A new LC method is introduced with the concept of its versatile application to widely used drugs from different pharmacological classes. Metformin hydrochloride (MTF), sitagliptin phosphate (SIT), simvastatin (SIM) and ezetimibe (EZB) were simultaneously determined with a simple reversed-phase LC method in which a SIT–SIM binary mixture, present in a dosage form brand, was considered central for its development. Chromatographic separation was achieved with a mobile phase of acetonitrile and 0.02 M potassium dihydrogen phosphate (pH 5.2) (77 + 23, v/v) flowing through a C18 column (BDS Hypersil, 250 × 4.6 mm, 5 µm) at 1.2 mL/min at ambient temperature. UV detection was programmed to be carried out at 210 nm for EZB, SIT, and MTF, whereas SIM was detected at 240 nm. The method was validated according to International Conference on Harmonization guidelines. Linearity, accuracy, and precision were satisfactory over concentration ranges 4–40 µg/mL for EZB and SIM, 0.5–50 µg/mL for SIT, and 5–500 µg/mL for MTF. Coefficients of determination were &gt;0.99 for the four drugs. LOQs found were 0.01 µg/mL for EZB, 0.02 µg/mL for SIT, 0.2 µg/mL for MTF, and 0.02 µg/mL for SIM. The developed method is simple, rapid, accurate, precise, and suitable for the routine QC analysis of the cited drugs in pharmaceutical products by conventional HPLC systems.
Habermas y Marcuse contra la ideología tecnocrática. Divergencias en la Teoría Crítica
Authors: Ortega Esquembre César 
Published: July 2017

<p><strong>Resumen: </strong>el presente trabajo pretende aportar, partiendo de la discusión en torno al papel ideológico que cumplen las fuerzas productivas en las sociedades industriales avanzadas, un rastreo genealógico de algunos de los conceptos fundamentales de la propuesta teórica de Jürgen Habermas. El análisis partirá de la original propuesta normativa, en términos de una formación discursiva de la voluntad política, con que Habermas trata de superar la conciencia tecnocrática, distanciándose de este modo de la primera Teoría Crítica, y más específicamente de Marcuse.</p><div><br clear="all" /><br /></div>
La noción de ley en Suárez y Locke
Authors: Prieto López Leopoldo José 
Published: July 2017

<p>Se puede afirmar que la concepción voluntarista de la ley en Locke es típicamente moderna. El empleo de un léxico que enfatiza el elemento volitivo como esencia de la ley tiene su origen en teorías antropológicas, jurídicas y teológicas tardomedievales, de las que Suárez es el principal vehículo en su transmisión a la modernidad. Sea directa, sea indirectamente, el influjo de la concepción suareciana de la ley sobre Locke es incontestable. El artículo indaga, finalmente, la secuencia histórica Suárez-Grotius-Locke en la búsqueda del hilo conductor del voluntarismo de dichos autores y replantea diversamente de como habitualmente es entendida la fórmula empleada por Grotius sobre la validez de la ley natural, a saber «etiamsi daremus non esse Deum» («etsi Deus non daretur»), cuyo verdadero sentido es indicar la relativa autonomía de la ley natural respecto de la voluntad divina.</p>
CASTILLO, Ramón del, FAERNA, Ángel M. & HICKMAN, Larry A. (eds.) (2015), Confines of Demcoracy. Essays on the Philosophy of Richard J. Bernstein: Brill.
Authors: Jiménez Perona Ángeles 
Published: July 2017

Reseña del libro: CASTILLO, Ramón del, FAERNA, Ángel M. &amp; HICKMAN, Larry A. (eds.) (2015), Confines of Demcoracy. Essays on the Philosophy of Richard J. Bernstein: Brill.
Le management de la légitimité : analyse du discours des enseignes spécialisées dans la distribution de produits biologiques
Authors: Zaidi-Chtourou Sabrina , Vernier Marie-France 
Published: July 2017

Alors que la consommation de produits dits « bio » concerne de plus en plus de consommateurs, les enseignes spécialisées sont confrontées à la concurrence de la grande distribution. Une nouvelle dynamique émerge avec une redéfinition du positionnement des enseignes spécialisées. Leur légitimité historique sur le marché du bio est-elle suffisante pour se positionner face aux grandes surfaces alimentaires ? À l’aide d’une approche qualitative menée à partir d’observations, de documents et d’entretiens de trois enseignes bio, cet article développe la typologie de légitimation de Suchman et souligne la coexistence de discours ambivalents utilisant parfois simultanément plusieurs aspects de la légitimité (morale, pragmatique et cognitive).
Lost in translation : la consommation de luxe comme révélateur de l’ajustement culturel du consommateur temporairement expatrié aux Émirats Arabes Unis
Authors: Chamaret Cécile , Parguel Béatrice 
Published: July 2017

Cet article envisage le comportement sur le marché du luxe du consommateur temporairement expatrié aux Émirats Arabes Unis comme un révélateur de son processus d’acculturation. Plus particulièrement, il étudie l’influence de la durée d’expatriation sur la consommation de produits de luxe. Au terme de deux études (qualitative et quantitative) conduites auprès de consommateurs français expatriés, il montre que ces derniers font d’abord l’expérience d’une phase de « lune de miel », avant d’entrer dans une phase d’« ajustement périphérique » pendant laquelle la distance au marché se réduit au fur et à mesure de l’expatriation.
Guérir une maladie ou « prendre soin » d’une personne ?
Authors: ROTHIER BAUTZER Eliane 
Published: July 2017

L’article analyse le travail soignant. Il synthétise les principaux résultats d’un travail de recherche ethnographique sur la formation infirmière. Il montre que le travail infirmier représente, dans sa relation au « prendre soin », un exemple paradigmatique des tensions à l’oeuvre entre deux formes de sollicitudes qui sont définies comme opposées car elles fondent des territoires professionnels hiérarchisés. La première est orientée vers la guérison de la maladie, la seconde vers le mieux-être, l’accompagnement d’une personne souffrante. L’auteur conclut en mettant en perspective ces résultats avec l’évolution des besoins de santé actuels qui requièrent une nouvelle articulation de ces deux formes de sollicitude.
Compromis sociaux d’usage dans l’accompagnement de l’apprentissage du prendre soin comme travail : le cas du portfolio et de l’approche par compétences en formation en soins infirmiers
Authors: CIAVALDINI-CARTAUT Solange , DUFOREST-REY Dianelle , WYBO Muriel 
Published: July 2017

Depuis la réforme de 2009 de la formation en soins infirmiers l’usage du portfolio doit faciliter le suivi de l’acquisition des compétences professionnelles des étudiants dans le contexte de l’alternance (Scallon, 2007 ; Tardif, 2006), mais également documenter une démarche de soin éthique en situation (Jonnaert, 2011). Cette étude exploratoire fondée sur une méthode mixte s’intéresse aux compromis (Nachi, 2011) d’usage susceptibles d’exister entre les attentes institutionnelles relatives à l’approche par compétences et l’exploitation du portfolio par les professionnels de santé tuteurs de stage. Les résultats présentés aboutissent à des préconisations d’opérationnalisation du portfolio dans la perspective d’une formation de formateurs et « du prendre soin comme travail auquel on forme ».
Comment prendre soin de l’enfant hyperactif à l’école ? De l’élève indiscipliné à l’élève handicapé
Authors: RONCHEWSKI DEGORRE Stéphanie 
Published: July 2017

Prendre soin de l’enfant hyperactif à l’école, c’est donner deux sens au mot soin : le souci de la personne vulnérable et l’aide médicale. Avec la reconnaissance de son trouble du comportement, l’élève indiscipliné devient un élève handicapé. Mais comment un élève turbulent devient-il un cas psychiatrique ? Comment reconnaître à l’école un enfant hyperactif, c’est-à-dire, d’un point de vue médical, atteint d’un TDAH (trouble du déficit de l’attention avec ou sans hyperactivité) ? Les enseignants contribuent au diagnostic médical en remplissant des tests de comportement. Ensuite, pour être pris en charge, l’enfant devra faire reconnaître son hyperactivité comme un handicap. Pour aider l’enseignant, le médecin lui donnera des conseils pour faire son cours. Ce partenariat souhaitable soulève aussi des difficultés. Entre un enseignant auxiliaire paramédical et un médecin pédagogue ne risque-t-on pas d’assister à une dilution des fonctions ? La levée du secret médical réclamée par certains enseignants est emblématique de cette confusion. La distinction de Canguilhem entre le normal et le pathologique, guidera notre réflexion sur la prise en charge médicale de l’enfant hyperactif à l’école. Ce cas suscite une interrogation éthique sur la médicalisation de notre société.
Les pratiques professionnelles dans un centre de lutte antituberculeuse : l’observation et l’implication
Authors: DA SILVA SANTOS Karen , ALONSO Patricia , MAGALI FORTUNA Cinira 
Published: July 2017

L’objectif principal de cette étude a été d’analyser les pratiques professionnelles relatives à la lutte antituberculeuse au sein d’un CLAT (centre de lutte antituberculeuse) du centre ouest de la France. Pour ce faire, nous avons mobilisé quelques approches conceptuelles du cadre théorique de l’analyse institutionnelle : l’observation et l’analyse des implications, à travers des entretiens avec des étudiants étrangers, des usagers étrangers ainsi qu’une infirmière et un médecin qui travaillent en CLAT. Nous avons procédé à l’analyse des documents institutionnels disponibles en ligne, à usage professionnel, et utilisé le journal de recherche comme outil afin d’éclairer les interactions et enjeux de la réalité observée. La recherche montre que la formation initiale des professionnels de santé à la tuberculose est insuffisante même si les médecins bénéficient d’une formation plus spécialisée pour travailler en CLAT. Cependant, cette carence n’est pas la principale difficulté. Du point de vue des usagers et des professionnels, celle-ci se situe dans la maîtrise plus ou moins bonne de la langue française. Le processus de communication comme analyseur des pratiques professionnelles est un élément d’identification des aspects d’humanisation dans l’accueil thérapeutique. Les pratiques professionnelles relatives à la lutte antituberculeuse, dans le CLAT observé, apparaissent construites objectivement et subjectivement dans la rencontre des implications libidinales et institutionnelles des professionnels et des usagers.
Elimination of HCV as a public health concern among people who inject drugs by 2030 – What will it take to get there?
Authors: Grebely Jason , Dore Gregory J. , Morin Sébastien , Rockstroh Jürgen K. , Klein Marina B. 
Published: July 2017

AbstractIntroduction: Globally, there is a considerable burden of HCV and HIV infections among people who inject drugs (PWID) and transmission of both infections continues. Needle and syringe programme (NSP) and opioid substitution therapy (OST) coverage remains low, despite evidence demonstrating their prevention benefit. Direct‐acting antiviral therapies (DAA) with HCV cure >95% among PWID provide an opportunity to reverse rising trends in HCV‐related morbidity and mortality and reduce incidence. However, HCV testing, linkage to care, and treatment remain low due to health system, provider, societal, and patient barriers. Between 2015 and 2030, WHO targets include reducing new HCV infections by 80% and HCV deaths by 65%, and increasing HCV diagnoses from <5% to 90% and number of eligible persons receiving HCV treatment from <1% to 80%. This commentary discusses why PWID should be considered as a priority population in these efforts, reasons why this goal could be attainable among PWID, challenges that need to be overcome, and key recommendations for action.Discussion: Challenges to HCV elimination as a global health concern among PWID include poor global coverage of harm reduction services, restrictive drug policies and criminalization of drug use, poor access to health services, low HCV testing, linkage to care and treatment, restrictions for accessing DAA therapy, and the lack of national strategies and government investment to support WHO elimination goals. Key recommendations for action include reforming drug policies (decriminalization of drug use and/or possession, or providing alternatives to imprisonment for PWID; decriminalization of the use and provision of sterile needles‐syringes; and legalization of OST for people who are opioid dependent), scaling up and improving funding for harm reduction services, making health services accessible for PWID, supporting community empowerment and community‐based programmes, improving access to affordable diagnostics and medicines, and eliminating stigma, discrimination, and violence against PWID.Conclusions: The ambitious targets for HCV elimination set by WHO are achievable in many countries, but will require researchers, healthcare providers, policy makers, affected communities, advocates, the pharmaceutical and diagnostics industries, and governments around the world to work together to make this happen.
Vitreous Punctate Spots in Eyes with Intermediate and Posterior Uveitis Using Spectral Domain Optical Coherence Tomography
Authors: Mehrotra Navneet , Nagpal Manish , Vishnoi Avijit , Mehta Rajen , Jain Hardik 
Published: July 2017

Purpose:-
To assess inflammatory cells in the vitreous which are seen as punctate spots on Nidek Spectral Domain Optical Coherence Tomography in eyes with intermediate and posterior uveitis.

Materials and Methods:-
This prospective study involved 73 eyes having intermediate and posterior uveitis which were imaged with Spectral Domain Optical Coherence Tomography (SDOCT) at baseline and 1 month after the treatment. The punctate spots were seen as hyper-reflective dots in the retina and vitreous. These were larger with greater density than the nonpunctate, irregular condensations seen in the vitreous cavity, reflecting normal age-related vitreous syneretic changes. The presence and severity of vitreous haze were classified according to the National Eye Institute system. The vitreous haze scale and SD-OCT findings were compared at baseline and 1 month after treatment.

Results:-
At baseline, SD-OCT showed inflammatory cells as numerous punctate spots in the vitreous cavity and retina in all eyes with decrease in their number on follow up.

Conclusion:-
The inflammatory cells in the vitreous and retina in eyes with intermediate and posterior uveitis were objectively documented using SD-OCT. SD-OCT is a useful imaging tool to correlate the reduction in inflammatory cells with vitreous haze seen clinically following treatment.
A Study on Eye Donation Awareness Among Medical and Engineering Students in Puducherry
Authors: Vallinayagam Muthukrishnan , Kumar Pranav S. , Krishnamoorthy Jayalatha , Arumugam Rajkumar 
Published: July 2017

Background:-
It is observed that 12% of the worldʼs blind population is affected by corneal blindness, a visual impairment that is amenable to treatment. The alarming figures rise every year, keeping India in the lead. Corneal transplantation remains the main-stay of treatment for restoring vision in such patients. Literature review in India reveals that the awareness about eye donation in public, especially among the youth is very low. Hence creation of awareness carries paramount importance. The aim of this study is to compare awareness between the Medical and Engineering college students in Puducherry and to explore ways to involve medical community and other sectors.

Materials and Methods:-
Students following their respective courses (I - IV year) during January to June 2016 participated in the study. Out of 679 students, 277 were medical and 402 were engineering students. The study started with initial clarification of questions followed by administration of pretested and semi-structured questionnaire with informed consent. The results were derived through statistical analysis.

Results:-
All the students were aware of eye donation. Awareness on various parameters is higher among the medical students. Television channels were considered as the most powerful tool amongst the media-to reach out to the public.

Conclusion:-
The study is in agreement with similar studies towards the necessity for awareness creation. Creation of awareness on eye donation can greatly improve current statistics. The medical students, in close collaboration with the community groups like Non Governmental Organisations, can reach out to public. The eyebanks and medical colleges can be linked up for advocacy programmes. Education on organ donation is a must for the society. The student community, medical and paramedical staff should be actively involved in this regard. Media campaign can play a commendable role to reach out to the masses for optimum benefit.
Drug Utilization Study In Primary Glaucoma Patients Attending the Ophthalmology Outpatient Department of a Tertiary Care Hospital in Western Uttar Pradesh
Authors: Parween Nazia , Gupta Surabhi , Kumar Sanjiv , Jain Kirti , Khosla P.P. , Kansal Saurabh , Khan Wase 
Published: July 2017

Objective:-
To evaluate prescription patterns for patients seeking consultation for various types and subtypes of primary glaucoma.

Methods:-
It was an observational study of one year duration. All primary glaucoma patients visiting the eye outpatient department were included. Their demographic data, clinical findings and common group of drugs prescribed were tabulated and analyzed.

Results:-
Out of 116 patients, 66 (56.90%) were males and 50 (43.10%) females. The mean age at presentation was 52.88±15.19 years. Primary open angle glaucoma was found to be the most common (54.0%) type, followed by primary angle closure glaucoma (41.0 %). The common group of drugs prescribed included beta blockers (38.12%), followed by carbonic anhydrase inhibitors, prostaglandin F2α analogues, α2 agonist and cholinergic agonist (14.36% each)

Conclusion:-
In primary glaucoma, the most common subtype was POAG, followed by angle closure glaucoma. Beta blockers were the most common group of drugs prescribed.
A model for 12CH2D2 and 13CH3D as complementary tracers for the budget of atmospheric CH4
Authors: Haghnegahdar Mojhgan A. , Schauble Edwin A. , Young Edward D. 
Published: July 2017

AbstractWe present a theoretical model to investigate the potential of 13CH3D and 12CH2D2, the doubly substituted mass‐18 isotopologues of methane, as tools for tracking atmospheric methane sources and sinks. We use electronic structure methods to estimate kinetic isotope fractionations associated with the major sink reactions of methane in air (reactions with OH and Cl radicals) and combine literature data with reconnaissance measurements of the relative abundances of 13CH3D and 12CH2D2 to estimate the compositions of the largest atmospheric sources. This model atmospheric budget is investigated with a simplified box model in which we explore both steady state and dynamical (nonsteady state) conditions triggered by changes in emission or sink fluxes. The steady state model predicts that sink reactions will generate a marked (>100‰) clumped isotope excess in atmospheric Δ12CH2D2 relative to the net source composition. 12CH2D2 measurements may thus be useful for tracing both atmospheric source and sink fluxes. The effect of sinks on Δ13CH3D is much less pronounced, indicating that 13CH3D in air will give a more focused picture of the source composition.
Microstructural analysis and calcite piezometry on hydrothermal veins: Insights into the deformation history of the Cocos Plate at Site U1414 (IODP Expedition 344)
Authors: Brandstätter Jennifer , Kurz Walter , Rogowitz Anna 
Published: July 2017

AbstractIn this study we present microstructural data from hydrothermal veins in the sedimentary cover and the igneous basement recovered from Hole U1414A, Integrated Ocean Drilling Program (IODP) Expedition 344 (Costa Rica Seismogenesis Project), to constrain deformation mechanism operating in the subducting Cocos Plate. Cathodoluminescence studies, mechanical e‐twin piezometry and electron backscatter diffraction (EBSD) analyses of carbonate veins were used to give insights into the deformation conditions and to help to understand the tectonic deformation history of the Cocos Plate offshore Costa Rica. Analyses of microstructures in the sedimentary rocks and in the basalt of the igneous basement reveal brittle deformation, as well as crystal‐plastic deformation of the host rock and the vein material. Cathodoluminescence images showed that in the basalt fluid flow and related precipitation occurred over several episodes. The differential stresses, obtained from two different piezometers using the same parameter (twin density), indicate various mean differential stresses of 49 ± 11 and 69 ± 30 MPa and EBSD mapping of calcite veins reveals low‐angle subgrain boundaries. Deformation temperatures are restricted to the range from 170°C to 220°C, due to the characteristics of the existing twins and the lack of high‐temperature intracrystalline deformation mechanisms (>220°C). The obtained results suggest that deformation occurred over a period associated with changes of ambient temperatures, occurrence of fluids and hydrofracturing, induced differential stresses due to the bending of the plate at the trench, and related seismic activity.
A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators
Authors: Hassani Faezeh Arab , Peh Wendy Yen Xian , Gammad Gil Gerald Lasam , Mogan Roshini Priya , Ng Tze Kiat , Kuo Tricia Li Chuen , Ng Lay Guat , Luu Percy , Yen Shih‐Cheng , Lee Chengkuo 
Published: July 2017

AbstractUnderactive bladder or detrusor underactivity (DU) is defined as a reduction of contraction strength or duration of the bladder wall. Despite the serious healthcare implications of DU, there are limited solutions for affected individuals. A flexible 3D printed implantable device driven by shape memory alloys (SMA) actuators is presented here for the first time to physically contract the bladder to restore voluntary control of the bladder for individuals suffering from DU. This approach is used initially in benchtop experiments with a rubber balloon acting as a model for the rat bladder to verify its potential for voiding, and that the operating temperatures are safe for the eventual implantation of the device in a rat. The device is then implanted and tested on an anesthetized rat, and a voiding volume of more than 8% is successfully achieved for the SMA‐based device without any surgical intervention or drug injection to relax the external sphincter.