bluuebunny/crossref_metadata_2025_split huggingface dataset:
High mortality from Guillain‐Barré syndrome in Bangladesh
Authors: Ishaque Tanveen , Islam Mohammad B. , Ara Gulshan , Endtz Hubert P. , Mohammad Quazi D. , Jacobs Bart C. , Islam Zhahirul 
Published: April 2017

AbstractAlthough Guillain‐Barré syndrome (GBS) has higher incidence and poor outcome in Bangladesh, mortality from GBS in Bangladesh has never been explored before. We sought to explore the frequency, timing, and risk factors for deaths from GBS in Bangladesh. We conducted a prospective study on 407 GBS patients who were admitted to Dhaka Medical College Hospital, Dhaka, Bangladesh from 2010 to 2013. We compared deceased and alive patients to identify risk factors. Cox regression model was used to adjust for confounders. Of the 407 GBS patients, 50 (12%) died, with the median time interval between the onset of weakness and death of 18 days. Among the fatal cases, 24 (48%) were ≥40 years, 36 (72%) had a Medical Research Council sum score ≤20 at entry, 33 (66%) had a progressive phase <8 days, and 27 (54%) required ventilation support. Ten patients (20%) died due to unavailability of ventilator. The strongest risk factor for deaths was lack of ventilator support when it was required (HR: 11.9; 95% confidence interval [CI]: 4.6–30.7). Other risk factors for death included age ≥40 years (HR: 5.9; 95% CI: 2.1–16.7), mechanical ventilation (HR: 2.3; 95% CI: 1.02–5.2), longer progressive phase (>8 days) (HR: 2.06; 95% CI: 1.1–3.8), autonomic dysfunction (HR: 1.9; 95% CI: 1.05–3.6), and bulbar nerve involvement (HR: 5.4; 95% CI: 1.5–19.2). In Bangladesh, GBS is associated with higher mortality rates, which is related to lack of ventilator support, disease severity, longer progressive phase of the disease, autonomic dysfunction, and involvement of the bulbar nerves.
A complex homozygous mutation in ABHD12 responsible for PHARC syndrome discovered with NGS and review of the literature
Authors: Lerat Justine , Cintas Pascal , Beauvais‐Dzugan Hélène , Magdelaine Corinne , Sturtz Franck , Lia Anne‐Sophie 
Published: April 2017

AbstractPHARC syndrome (MIM612674) is an autosomal recessive neurodegenerative pathology that leads to demyelinating Polyneuropathy, Hearing loss, cerebellar Ataxia, Retinitis pigmentosa, and early‐onset Cataracts (PHARC). These various symptoms can appear at different ages. PHARC syndrome is caused by mutations in ABHD12 (α‐β hydrolase domain 12), of which several have been described. We report here a new complex homozygous mutation c.379_385delAACTACTinsGATTCCTTATATACCATTGTAGTCTTACTGCTTTTGGTGAACACA (p.Asn127Aspfs*23). This mutation was detected in a 36‐year‐old man, who presented neuropathic symptoms from the age of 15, using a next‐generation sequencing panel. This result suggests that the involvement of ABHD12 in polyneuropathies is possibly underestimated. We then performed a comparative study of other patients presenting ABHD12 mutations and searched for genotype‐phenotype correlations and functional explanations in this heterogeneous population.
Clinical characterization and genetic analysis of Korean patients with X‐linked Charcot‐Marie‐Tooth disease type 1
Authors: Hong Young B. , Park Jin‐Mo , Yu Jin S. , Yoo Da H. , Nam Da E. , Park Hyung J. , Lee Ji‐Su , Hwang Sun H. , Chung Ki W. , Choi Byung‐Ok 
Published: April 2017

AbstractMutations in the gap junction protein beta 1 gene (GJB1) cause X‐linked Charcot‐Marie‐Tooth disease type 1 (CMTX1). CMTX1 is representative of the intermediate type of CMT, having both demyelinating and axonal neuropathic features. We analyzed the clinical and genetic characterization of 128 patients with CMTX1 from 63 unrelated families. Genetic analysis revealed a total of 43 mutations including 6 novel mutations. Ten mutations were found from two or more unrelated families. p.V95M was most frequently observed. The frequency of CMTX1 was 9.6% of total Korean CMT family and was 14.8% when calculated within genetically identified cases. Among 67 male and 61 female patients, 22 females were asymptomatic. A high‐arched foot, ataxia, and tremor were observed in 87%, 41%, and 35% of the patients, respectively. In the male patients, functional disability scale, CMT neuropathy score, and compound muscle action potential of the median/ulnar nerves were more severely affected than in the female patients. This study provides a comprehensive summary of the clinical features and spectrum of GJB1 gene mutations in Korean CMTX1 patients.
Oral health beliefs, knowledge, and behaviors in Northern California American Indian and Alaska Native mothers regarding early childhood caries
Authors: Heaton Brenda , Crawford Andrew , Garcia Raul I. , Henshaw Michelle , Riedy Christine A. , Barker Judith C. , Wimsatt Maureen A. ,   for the Native Oral Health Project
Published: April 2017

AbstractObjectivesTo assess the oral health beliefs, knowledge, and behaviors related to early childhood caries (ECC) risk in a convenience sample of American Indian and Alaska Native (AIAN) mothers residing in rural Northern California communities.MethodsFifty‐three mothers of young children were recruited from three tribal communities in Northern California with the assistance of the California Rural Indian Health Board, Inc. and its California Tribal Epidemiology Center and Dental Support Center. Trained study staff administered questionnaires to obtain basic socio‐demographic information, to survey participants on their oral health beliefs, knowledge, and behaviors as related to ECC risk, and to identify possible barriers to their accessing professional oral health care. Analyses of covariance were used to explore associations between socio‐demographic indicators and oral health behaviors, after controlling for knowledge, beliefs and barriers to care.ResultsOverall, 53 percent of participants reported their oral health as “fair” or “poor.” Mothers' education (high) and being employed were positively associated with better oral health behavior scores. Additionally, 72 percent of mothers reported having one or more barriers to oral health care including access. There was a significant relation (P = 0.03) between high number of reported barriers to oral health care and low oral health behavior scores.ConclusionsDespite generally high‐level oral health knowledge, perceptions of self and child oral health remains low in this sample of AIAN mothers. Factors identified as being associated with oral health behaviors in this sample were similar to those found in other health disparities populations.
Activity of anti-inflammatory, analgesic and antigenotoxic of the aqueous flower extracts of Opuntia microdasys Lem.Pfeiff
Authors: Chahdoura Hassiba , El Bok Safia , Refifa Taoufik , Adouni Khaoula , Khemiss Fethia , Mosbah Habib , Ben-Attia Mossadok , Flamini Guido , Achour Lotfi 
Published: April 2017

Abstract

Objectives
The aim of this study was to evaluate the analgesic and the anti-inflammatory activity of Opuntia microdasys at post flowering stage, F3 (OMF3) in rat and, in other hand, its antigenotoxic effects by the Allium cepa test.

Methods
OMF3 extracts were screened for activity of analgesic and anti-inflammatory using, respectively, the acetic acid writhing test in mice and the carrageenan-induced paw oedema assay in rats. The antigenotoxic has been evaluated by A. cepa test.

Key findings
OMF3 extracts showed a higher analgesic and anti-inflammatory activity at 100 mg/kg (72.03% and 70.11%) as determined by the tests of acetic acid-induced writhing and carrageenan-induced oedema, respectively. Furthermore, the OMF3 aqueous extracts have a preventive antimutagenic potential, at lower concentration (EC50 ≈ 60 μg/ml), against H2O2-mediated DNA damage in A. cepa root meristem cells with an efficient restoration of the mitotic index in comparison with controls.

Conclusions
Based on this study, the flower of O. microdasys at post flowering stage may be use as an analgesic, anti-inflammatory and antimutagenic agents.
Estimation of maintenance energy requirements in German shepherd and Labrador retriever dogs in Bangalore, India
Authors: Madhusudhan H. S. , Chandrapal Singh K. , Krishnamoorthy U. , Umesh K. G. , Butterwick R. , Wrigglesworth D. 
Published: April 2017

SummaryMaintenance energy requirements (MERs) were calculated for 17 German shepherd and 20 Labrador retriever adult dogs using an in‐home prospective dietary trial. The dogs were fed the same dry pet food and body weight, food intake, body condition score and physical activity were monitored for 10 weeks. Labrador retrievers were significantly heavier and had higher body condition scores than German shepherd dogs, but there was no difference between males and females within each group. Body weights remained stable over the study period, with an average daily gain of 9.1 g. Mean (SD) MER was 103.4 (16.3) kcal/kg BW0.75, which was some 20% lower than that currently suggested for moderately active young adult dogs. Individual MER ranged from 66.8 to 141 kcal/kg BW0.75. There were no significant differences in MER between the two breeds, or between males and females within and between the two breeds. There was a significant inverse relationship between MER and body condition score, reflecting the lower energy expenditure of adipose tissue. The lower MER of dogs in this study, relative to previous observations, may reflect climatic and environmental differences and highlight the necessity for accurate estimates of MER in relation to the production and feeding of pet foods.
Effect of oil and shortening in rice bread quality: Relationship between dough rheology and quality characteristics
Authors: Mancebo Camino M. , Martínez Mario M. , Merino Cristina , de la Hera Esther , Gómez Manuel 
Published: April 2017

AbstractOne of the main problems with gluten‐free breads is their texture and their rapid staling. Fats are widely used for the improvement of texture and other quality parameters in gluten‐free breads. The effect of oil and shortening in rice‐breads quality and its correlation with dough rheology has been analyzed. The inclusion of oil increased the specific volume of the breads and reduced their hardness, particularly with lower levels of hydration, whereas shortening did not modify specific volume or reduced it when hydration levels were higher. Oil, at levels of up to 30%, reduced the cohesiveness, springiness and resilience of breads, as well as the brightness of the crust, and increased the a* and b* values. Breads with oil also exhibited a greater number of pores per cm2, especially in doughs with higher levels of hydration. An inverse correlation between G′ and G′′ and bread specific volume has been observed, being the reciprocal‐Y model a better predictor than the linear model to relate the bread specific volume.Practical applicationsThis study showed that the type and quantity of fat added in rice based breads affect the bread quality in a different way. In general, it can be said that the incorporation of up to 20% oil improved rice based breads. Oil increased the specific volume, the a* and b* parameters of the crust and the cell density. It also decreases hardness, cohesiveness, springiness, resilience, and the L* parameter. Converse to breads made with oil, the addition of shortening can negatively affect the quality of the breads. Moreover, the correlation analysis has demonstrated that the study of dough rheology could be a good predictor of gluten‐free bread quality.
Meteorite falls in Bulgaria: Reappraisal of mineralogy, chemistry, and classification
Authors: Dekov Vesselin , Rochette Pierre , Gattacceca Jérôme 
Published: April 2017

AbstractWe present a summary of the mineralogy, mineral chemistry, and magnetic characteristics of all the five Bulgarian meteorite falls. We report the first mineralogical descriptions, chemical analyses, and magnetic measurements of the Konevo (1931) and Silistra (1917) meteorites. We classify Konevo as LL5, and Silistra as an ungrouped achondrite with HED affinities. Pavel (1966; previously classified as an H5) is reclassified as H3‐anomalous. We also provide precise mineralogy and mineral chemistry of the Virba meteorite (1873, L6), and more details on the mineral chemistry of Gumoschnik (1904, H5).
Iron status, body size, and growth in the first 2 years of life
Authors: McCarthy Elaine K. , ní Chaoimh Carol , Kenny Louise C. , Hourihane Jonathan O'B , Irvine Alan D. , Murray Deirdre M. , Kiely Mairead E. 
Published: April 2017

AbstractRapid growth in infancy has been shown to adversely affect iron status up to 1 year; however the effect of growth on iron status in the second year of life has been largely unexplored. We aimed to investigate the impact of growth and body size in the first 2 years on iron status at 2 years. In the prospective, maternal‐infant Cork BASELINE Birth Cohort Study, infant weight and length were measured at birth, 2, 6, 12, and 24 months and absolute weight (kg) and length (cm) gain from 0 to 2, 0 to 6, 0 to 12, 6 to 12, 12 to 24, and 0 to 24 months were calculated. At 2 years (n = 704), haemoglobin, mean corpuscular volume, and serum ferritin (umbilical cord concentrations also) were measured. At 2 years, 5% had iron deficiency (ferritin < 12 μg/L) and 1% had iron deficiency anaemia (haemoglobin < 110 g/L + ferritin < 12 μg/L). Weight gain from 6 to 12, 0 to 24, and 12 to 24 months were all inversely associated with ferritin concentrations at 2 years but only the association with weight gain from 12 to 24 months was robust after adjustment for potential confounders including cord ferritin (adj. estimate 95% CI: −4.40 [−8.43, −0.37] μg/L, p = .033). Length gain from 0 to 24 months was positively associated with haemoglobin at 2 years (0.42 [0.07, 0.76] g/L, p = .019), only prior to further adjustment for cord ferritin. To conclude, weight gain in the second year was inversely associated with iron stores at 2 years, even after accounting for iron status at birth. Further examinations of iron requirements, dietary intakes, and growth patterns in children in the second year of life in high‐resource settings are warranted.
Rescue pallidal stimulation for diphasic and stimulation‐induced dyskinesia after successful subthalamic stimulation for Parkinson's disease
Authors: Nakajima Asuka , Oyama Genko , Jo Takayuki , Shimo Yasushi , Umemura Atsushi , Nakajima Madoka , Ishii Hisato , Arai Hajime , Hattori Nobutaka 
Published: April 2017

AbstractA 64‐year‐old woman with Parkinson's disease who developed motor fluctuations, and both levodopa‐induced and stimulation‐induced dyskinesia, after long‐term treatment of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS), underwent implantation of additional globus pallidus internus (GPi) DBS leads. Although an appropriate DBS target should be chosen, “rescue” GPi DBS can synergistically work with pre‐existing STN DBS for the treatment of dyskinesia, which might provide a “third honeymoon.”
Relationship between cytotoxic T‐lymphocyte antigen 4 ‐318C/T (rs5742909) gene polymorphism and the risk of acute rejection in renal transplantation
Authors: Yang Chun‐Hua , Chen Xue‐Xia , Chen Li , Zheng Dong‐Hua , Liu Qiong‐Shan , Xie Wen‐Feng , Zhou Tian‐Biao , Drummen Gregor P. C. 
Published: April 2017

AbstractResults on the relationship between CTLA4 ‐318C/T (rs5742909) gene polymorphism and risk of acute rejection in renal transplantation are still conflicting. This meta‐analysis was performed to update the association between CTLA4 ‐318C/T and risk of acute rejection in renal transplantation. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta‐analysis method. Twelve reports were included in this meta‐analysis for the association of CTLA4 ‐318C/T gene polymorphism with acute rejection risk in renal transplantation, consisting of 728 acute rejection patients and 1628 non‐acute rejection controls. The association between CTLA4 ‐318C/T gene polymorphism and acute rejection risk in renal transplantation for overall populations was not found in this meta‐analysis (T allele: OR=0.96, 95% CI: 0.60‐1.54, P=.88; TT genotype: OR=0.90, 95% CI: 0.47‐1.71, P=.74; CC genotype: OR=1.00, 95% CI: 0.62‐1.59, P=.98). Interestingly, T allele was associated with the risk of acute rejection in renal transplantation in African population. In conclusion, CTLA4 ‐318C/T gene polymorphism is not associated with the risk of acute rejection in renal transplantation in overall populations.
Resting sympathetic arousal moderates the association between parasympathetic reactivity and working memory performance in adults reporting high levels of life stress
Authors: Giuliano Ryan J. , Gatzke‐Kopp Lisa M. , Roos Leslie E. , Skowron Elizabeth A. 
Published: April 2017

AbstractThe neurovisceral integration model stipulates that autonomic function plays a critical role in the regulation of higher‐order cognitive processes, yet most work to date has examined parasympathetic function in isolation from sympathetic function. Furthermore, the majority of work has been conducted on normative samples, which typically demonstrate parasympathetic withdrawal to increase arousal needed to complete cognitive tasks. Little is known about how autonomic regulation supports cognitive function in populations exposed to high levels of stress, which is critical given that chronic stress exposure alters autonomic function. To address this, we sought to characterize how parasympathetic (high‐frequency heart rate variability, HF‐HRV) and sympathetic (preejection period, PEP) measures of cardiac function contribute to individual differences in working memory (WM) capacity in a sample of high‐risk women. HF‐HRV and PEP were measured at rest and during a visual change detection measure of WM. Multilevel modeling was used to examine within‐person fluctuations in WM performance throughout the task concurrently with HF‐HRV and PEP, as well as between‐person differences as a function of resting HF‐HRV and PEP levels. Results indicate that resting PEP moderated the association between HF‐HRV reactivity and WM capacity. Increases in WM capacity across the task were associated with increases in parasympathetic activity, but only among individuals with longer resting PEP (lower sympathetic arousal). Follow‐up analyses showed that shorter resting PEP was associated with greater cumulative risk exposure. These results support the autonomic space framework, in that the relationship between behavior and parasympathetic function appears dependent on resting sympathetic activation.
The effect of sclerotherapy and prolotherapy on chronic painful Achilles tendinopathy—a systematic review including meta‐analysis
Authors: Morath O. , Kubosch E. J. , Taeymans J. , Zwingmann J. , Konstantinidis L. , Südkamp N. P. , Hirschmüller A. 
Published: April 2017

Chronic painful Achilles tendinopathy (AT) is a common disorder among athletes. Sclerotherapy (ST) and prolotherapy (PT) are two promising options among the numerous other conservative therapies. As their efficacy and potential adverse effects (AE) are still unclear, we systematically searched, analyzed, and synthesized the available literature on ST and PT for treating AT. Electronic databases, Google Scholar and articles’ reference lists were searched according to PRISMA guidelines. Eligibility criteria were set up according to the PICOS‐scheme including human and animal studies. Three authors independently reviewed the results and evaluated methodological quality (Coleman Methodology Score and Cochrane Risk of Bias Assessment). The initial search yielded 1104 entries. After screening, 18 articles were available for qualitative synthesis, six of which were subjected to meta‐analysis. The mean Coleman Score of the 13 human studies was 50. Four RCTs were ranked as having a low risk of selection bias. Three of those reported a statistically significant drop in the visual analog scale (VAS) score, one a significant increase in the VISA‐A Score. 12 of 13 human studies reported positive results in achieving pain relief and patient satisfaction, whereas only one study's finding differed. Meta‐analysis revealed an unambiguous result in favor of the intervention (weighted mean difference D=−4.67 cm, 95% CI −5.56 to −3.76 cm [P<.001]). Only one serious AE and two minor AEs were reported in the entire literature. This systematic review suggests that ST and PT may be effective treatment options for AT and that they can be considered safe. Long‐term studies and RCTs are still needed to support their recommendation.
Skeletal muscle IL‐15/IL‐15Rα and myofibrillar protein synthesis after resistance exercise
Authors: Pérez‐López A. , McKendry J. , Martin‐Rincon M. , Morales‐Alamo D. , Pérez‐Köhler B. , Valadés D. , Buján J. , Calbet J. A. L. , Breen L. 
Published: April 2017

In vitro and in vivo studies described the myokine IL‐15 and its receptor IL‐15Rα as anabolic/anti‐atrophy agents, however, the protein expression of IL‐15Rα has not been measured in human skeletal muscle and data regarding IL‐15 expression remain inconclusive. The purpose of the study was to determine serum and skeletal muscle IL‐15 and IL‐15Rα responses to resistance exercise session and to analyze their association with myofibrillar protein synthesis (MPS). Fourteen participants performed a bilateral leg resistance exercise composed of four sets of leg press and four sets of knee extension at 75% 1RM to task failure. Muscle biopsies were obtained at rest, 0, 4 and 24 hours post‐exercise and blood samples at rest, mid‐exercise, 0, 0.3, 1, 2, 4 and 24 hours post‐exercise. Serum IL‐15 was increased by ~5.3‐fold immediately post‐exercise, while serum IL‐15Rα decreased ~75% over 1 hour post‐exercise (P<.001). Skeletal muscle IL‐15Rα mRNA and protein expression were increased at 4 hours post‐exercise by ~2‐fold (P<.001) and ~1.3‐fold above rest (P=.020), respectively. At 24 hours post‐exercise, IL‐15 (P=.003) and IL‐15Rα mRNAs increased by ~2‐fold (P=.002). Myofibrillar fractional synthetic rate between 0‐4 hours was associated with IL‐15Rα mRNA at rest (r=.662, P=.019), 4 hours (r=.612, P=.029), and 24 hours post‐exercise (r=.627, P=.029). Finally, the muscle IL‐15Rα protein up‐regulation was related to Leg press 1RM (r=.688, P=.003) and total weight lifted (r=.628, P=.009). In conclusion, IL‐15/IL‐15Rα signaling pathway is activated in skeletal muscle in response to a session of resistance exercise.
Influence of a 2‐ to 6‐year physical education intervention on scholastic performance: The CHAMPS study‐DK
Authors: Bugge Anna , Möller Sören , Tarp Jakob , Hillman Charles H. , Lima Rodrigo Antunes , Gejl Anne Kær , Klakk Heidi , Wedderkopp Niels 
Published: April 2017

The aim of this study was to investigate the influence of a school‐based intervention with a tripling of physical education (PE) lessons from two (90 minutes) to six lessons per week (270 minutes) on scholastic performance. This study is part of the CHAMPS study‐DK, a quasi‐experimental study that began in 2008. The intervention group consisted of six schools, and the control group consisted of four matched schools (mean age at baseline=8.4 years, kindergarten class fourth grade). Academic performance was extracted from the national test system from 2010 to 2014 (Math and Danish were measured at third and sixth, and second, fourth and sixth grades, respectively). Participants included 1888 students participating in at least one scholastic performance test. Linear mixed models were applied to test for differences between groups and adjusted for known confounders. No significant differences were observed between groups in the academic performance tests (control group reference); Danish second grade β=−1.34 (95% CI −9.90, 7.22), fourth grade β=0.22 (95% CI −6.12, 6.56), sixth grade β=1.03 (95% CI −5.02, 7.08), and all grades combined β=0.28 (95% CI −5.74, 6.31) and Math third grade β=−2.87 (95% CI −9.65, 3.90), sixth grade β=0.99 (95% CI −7.36, 9.34) and combined β=−1.20 (95% CI −8.10, 5.71). In conclusion, no significant differences were observed between intervention and control schools for scholastic performance. Importantly, there were no negative effects of additional PE on scholastic outcomes, despite more PE and longer school days for intervention children.