bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shatter cones at the Keurusselkä impact structure and their relation to local jointing
Authors: Hasch Maximilian , Reimold Wolf Uwe , Raschke Ulli , Zaag Patrice Tristan 
Published: July 2016

AbstractShatter cones are the only distinct meso‐ to macroscopic recognition criterion for impact structures, yet not all is known about their formation. The Keurusselkä impact structure, Finland, is interesting in that it presents a multitude of well‐exposed shatter cones in medium‐ to coarse‐grained granitoids. The allegedly 27 km wide Keurusselkä impact structure was formed about 1150 Ma ago in rocks of the Central Finland Granitoid Complex. Special attention was paid in this work to possible relationships between shatter cones and local, as well as regionally occurring, fracture or joint systems. A possible shatter cone find outside the previously suggested edge of the structure could mean that the Keurusselkä impact structure is larger than previously thought. The spacing between joints/fractures from regional joint systems was influenced by the impact, but impact‐induced fractures strongly follow the regional joint orientation trends. There is a distinct relationship between shatter cones and joints: shatter cones occur on and against joint surfaces of varied orientations and belonging to the regional orientation trends. Planar fractures (PF) and planar deformation features (PDF) were found in three shatter cone samples from the central‐most part of the impact structure, whereas other country rock samples from the same level of exposure but further from the assumed center lack shock deformation features. PDF occurrence is enhanced within 5 mm of shatter cone surfaces, which is interpreted to suggest that shock wave reverberation at preimpact joints could be responsible for this local enhancement of shock deformation. Some shatter cone surfaces are coated with a quasi‐opaque material which is also found in conspicuous veinlets that branch off from shatter cone surfaces and resemble pseudotachylitic breccia veins. The vein‐filling is composed of two mineral phases, one of which could be identified as a montmorillonitic phyllosilicate. The second phase could not be identified yet. The original composition of the fill could not be determined. Further work is required on this material. Observed joints and fractures were discussed against findings from Barringer impact crater. They show that impact‐induced joints in the basement rock do not follow impact‐specific orientations (such as radial, conical, or concentric).
Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?
Authors: Bennett Kelly Louise , Shija Fortunate , Linton Yvonne‐Marie , Misinzo Gerald , Kaddumukasa Martha , Djouaka Rousseau , Anyaele Okorie , Harris Angela , Irish Seth , Hlaing Thaung , Prakash Anil , Lutwama Julius , Walton Catherine 
Published: July 2016

AbstractIncreasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future disease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti's adaption to human‐modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make‐up of the source population(s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, historical human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out‐of‐Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analysis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti.
An autopsied case of MM1 + MM2‐cortical with thalamic‐type sporadic Creutzfeldt‐Jakob disease presenting with hyperintensities on diffusion‐weighted MRI before clinical onset
Authors: Iwasaki Yasushi , Mori Keiko , Ito Masumi , Mimuro Maya , Kitamoto Tetsuyuki , Yoshida Mari 
Published: July 2016

A 78‐year‐old Japanese man presented with rapidly progressive dementia and gait disturbances. Eight months before the onset of clinical symptoms, diffusion‐weighted magnetic resonance imaging (DWI) demonstrated hyperintensities in the right temporal, right parietal and left medial occipital cortices. Two weeks after symptom onset, DWI showed extensive hyperintensity in the bilateral cerebral cortex, with regions of higher brightness that existed prior to symptom onset still present. Four weeks after clinical onset, periodic sharp wave complexes were identified on an electroencephalogram. Myoclonus was observed 8 weeks after clinical onset. The patient reached an akinetic mutism state and died 5 months after onset. Neuropathological examination showed widespread cerebral neocortical involvement of fine vacuole‐type spongiform changes with large confluent vacuole‐type spongiform changes. Spongiform degeneration with neuron loss and hypertrophic astrocytosis was also observed in the striatum and medial thalamus. The inferior olivary nucleus showed severe neuron loss with hypertrophic astrocytosis. Prion protein (PrP) immunostaining showed widespread synaptic‐type PrP deposition with perivacuolar‐type PrP deposition in the cerebral neocortex. Mild to moderate PrP deposition was also observed extensively in the basal ganglia, thalamus, cerebellum and brainstem, but it was not apparent in the inferior olivary nucleus. PrP gene analysis showed no mutations, and polymorphic codon 129 showed methionine homozygosity. Western blot analysis of protease‐resistant PrP showed both type 1 scrapie type PrP (PrPSc) and type 2 PrPSc. Based on the relationship between the neuroimaging and pathological findings, we speculated that cerebral cortical lesions with large confluent vacuoles and type 2 PrPSc would show higher brightness and continuous hyperintensity on DWI than those with fine vacuoles and type 1 PrPSc. We believe the present patient had a combined form of MM1 + MM2‐cortical with thalamic‐type sporadic Creutzfeldt‐Jakob disease (sCJD), which suggests a broader spectrum of sCJD clinicopathological findings.
Geographical thinking in nursing inquiry, part one: locations, contents, meanings
Authors: Andrews Gavin J. 
Published: July 2016

AbstractSpatial thought is undergoing somewhat of a renaissance in nursing. Building on a long disciplinary tradition of conceptualizing and studying ‘nursing environment’, the past twenty years has witnessing the establishment and refinement of explicitly geographical nursing research. This article – part one in a series of two – reviews the perspectives taken to date, ranging from historical precedent in classical nursing theory through to positivistic spatial science, political economy, and social constructivism in contemporary inquiry. This discussion sets up part two, which considers the potential of non‐representational theory for framing future studies.
Body–drug assemblages: theorizing the experience of side effects in the context of HIV treatment
Authors: Gagnon Marilou , Holmes Dave 
Published: July 2016

AbstractEach of the antiretroviral drugs that are currently used to stop the progression of HIV infection causes its own specific side effects. Despite the expansion, multiplication, and simplification of treatment options over the past decade, side effects continue to affect people living with HIV. Yet, we see a clear disconnect between the way side effects are normalized, routinized, and framed in clinical practice and the way they are experienced by people living with HIV. This paper builds on the premise that new approaches are needed to understand side effects in a manner that is more reflective of the subjective accounts of people living with HIV. Drawing on the work of Deleuze and Guattari, it offers an original application of the theory of ‘assemblage’. This theory offers a new way of theorizing side effects, and ultimately the relationship between the body and antiretroviral drugs (as technologies). Combining theory with examples derived from empirical data, we examine the multiple ways in which the body connects not only to the drugs but also to people, things, and systems. Our objective is to illustrate how this theory dares us to think differently about side effects and allows us to originally (re)think the experience of taking antiretroviral drugs.
Biomarkers in Persistent AF and Heart Failure: Impact of Catheter Ablation Compared with Rate Control
Authors: JONES DAVID G. , HALDAR SHOUVIK K. , DONOVAN JACQUELINE , MCDONAGH THERESA A. , SHARMA RAKESH , HUSSAIN WAJID , MARKIDES VIAS , WONG TOM 
Published: July 2016

BackgroundTo investigate the effects of catheter ablation and rate control strategies on cardiac and inflammatory biomarkers in patients with heart failure and persistent atrial fibrillation (AF).MethodsPatients were recruited from the ARC‐HF trial (catheter Ablation vs Rate Control for management of persistent AF in Heart Failure, NCT00878384), which compared ablation with rate control for persistent AF in heart failure. B‐type natriuretic peptide (BNP), midregional proatrial natriuretic peptide (MR‐proANP), apelin, and interleukin‐6 (IL‐6) were assayed at baseline, 3 months, 6 months, and 12 months. The primary end point, analyzed per‐protocol, was changed from baseline at 12 months.ResultsOf 52 recruited patients, 24 ablation and 25 rate control subjects were followed to 12 months. After 1.2 ± 0.5 procedures, sinus rhythm was present in 22 (92%) ablation patients; under rate control, rate criteria were achieved in 23 (96%) of 24 patients remaining in AF. At 12 months, MR‐proANP fell significantly in the ablation arm (–106.0 pmol/L, interquartile range [IQR] –228.2 to –60.6) compared with rate control (–28.7 pmol/L, IQR –69 to +9.5, P = 0.028). BNP showed a similar trend toward reduction (P = 0.051), with no significant difference in apelin (P = 0.13) or IL‐6 (P = 0.68). Changes in MR‐proANP and BNP correlated with peak VO2 and ejection fraction, and MR‐proANP additionally with quality‐of‐life score.ConclusionsCatheter ablation, compared with rate control, in patients with heart failure and persistent AF was associated with significant reduction in MR‐proANP, which correlated with physiological and symptomatic improvement. Ablation‐based rhythm control may induce beneficial cardiac remodeling, unrelated to changes in inflammatory state. This may have prognostic implications, which require confirmation by event end point studies.
Wittgenstein's Private Language Investigation
Authors: Lin Francis Y. 
Published: July 2016

AbstractIn this paper, I first review previous interpretations of Wittgenstein's remarks on private language, revealing their inadequacies, and then present my own interpretation. Basing mainly on Wittgenstein's notes for lectures on private sensations, I establish the following points: (i) ‘remembering the connection right’ means ‘reidentifying sensation‐types’; (ii) the reason for ‘no criterion of correctness’ is that nothing, especially no inner mechanisms nor external devices, can be utilised by the private speaker to tell whether some sensations are of one type or different types; and (iii) private names are not really names, private language is not really a language, therefore, private language is a grammatical illusion. My interpretation has the advantage of being able to reconcile Wittgenstein's conception of philosophy, which is to dissolve philosophical problems by rearranging grammatical facts, with his actual philosophical practice, at least in the case of private language.
Organizations, Policies, and the Roots of Public Value Failure: The Case of For‐Profit Higher Education
Authors: Anderson Derrick M. , Taggart Gabel 
Published: July 2016

AbstractWhile public value theory has emerged to offer important insights into the evaluation of social enterprises, little is known about the origins of public value failure and even less about the role that organizations and public policy play in creating public value failure. Accordingly, this analysis explores the origins of public value failure using examples from for‐profit higher education. A selection of organization and public policy concepts are integrated into a public value mapping framework to develop a theoretical basis for public value “failure drivers.” In addition to advancing public value theory, an understanding of the origins of public value failure and the role of failure drivers has important implications for the design of public value–maximizing strategies and institutions.
Limited Consumer Attention in International Trade
Authors: Egger Hartmut , Falkinger Josef 
Published: July 2016

AbstractThis paper introduces a model of limited consumer attention into an otherwise standard new trade theory model with love‐of‐variety preferences and heterogeneous firms. In this setting, we show that international integration needs not be welfare enhancing if the consumers' capacity to gather and process information is limited. Rather, it intensifies competition for scarce consumer attention, which causes mutual overbidding of producers in their advertising expenditures. The mutual overbidding renders advertising—which is informative in principle—wasteful and diverts purchases to imported goods at an inefficient scale. Wasteful advertising provides scope for policy intervention in the form of an advertising tax. However, if the tax instrument is not allowed to discriminate against foreign producers, it cannot eliminate inefficient diversion of consumer purchases to imports; hence it needs not be successful in securing gains from international integration in this framework.
Turbidite stacking patterns in salt‐controlled minibasins: Insights from integrated analogue models and numerical fluid flow simulations
Authors: Wang Xiaoxi , Luthi Stefan M. , Hodgson David M. , Sokoutis Dimitrios , Willingshofer Ernst , Groenenberg Remco M. 
Published: July 2016

ABSTRACTThe sea floor of intraslope minibasins on passive continental margins plays a significant role in controlling turbidity current pathways and the resulting sediment distribution. To address this, laboratory analogue modelling of intraslope minibasin formation is combined with numerical flow simulations of multi‐event turbidity currents. This approach permits an improved understanding of evolving flow–bathymetry–deposit interactions and the resulting internal stacking patterns of the infills of such minibasins. The bathymetry includes a shelf to slope channel followed by an upper minibasin, which are separated by a confining ridge from two lower minibasins that compares well with analogous bathymetries reported from natural settings. From a wider range of numerical flow experiments, a series of 100 consecutive flows is reported in detail. The turbidity currents are released into the channel and upon reaching the upper minibasin follow a series of stages from short initial ponding, ‘filling and spilling’ and an extended transition to long retrogradational ponding. Upon reaching the upper minibasin floor, the currents undergo a hydraulic jump and therefore much sediment is deposited in the central part of the minibasin and the counterslope. This modifies the bathymetry such that in the fill and spill stage, flow stripping and grain‐size partitioning cause some finer sediment to be transported across the confining ridge into the lower minibasins. Throughout the basin infill process, the sequences retrograde upstream, accompanied by lateral switching into locally formed depressions in the upper minibasin. After the fill and spill stage, significant deposition occurs in the channel where retrograding cyclic steps with wavelengths of 1 to 2 km develop as a function of pulsating flow criticality. These results are at variance with conventional schemes that emphasize sequential downstream minibasin filling through ponding dominated by vertical aggradation. Comparison of these results with published field and experimental examples provides support for the main conclusions.
Skin indentation firmness and tissue dielectric constant assessed in face, neck, and arm skin of young healthy women
Authors: Mayrovitz Harvey N. , Corbitt Kelly , Grammenos Alexandra , Abello Allen , Mammino Jason 
Published: July 2016

PurposeOur goal was to test the hypothesis that skin firmness correlates with skin hydration.MethodsDermal water was assessed by tissue dielectric constant (TDC) at 0.5 mm (TDC0.5) and 2.5 mm (TDC2.5) depths on four face sites and two arm sites of 35 women (25.0 ± 1.6 years). Firmness was determined by force (mN) to indent skin to 0.3 mm (F0.3) and 1.3 mm (F1.3).ResultsF0.3 was similar among face sites (avg = 16.2 ± 7.2 mN) but F1.3 varied (avg = 32.5 ± 4.1 mN). TDC2.5 was similar among face sites (avg = 37.7 ± 4.2) but TDC0.5 varied (avg = 36.2 ± 4.8). F1.3 of arm sites was similar (avg = 60.2 ± 18.6 mN) and both greater than F1.3 of neck (28.3 ± 7.1 mN) and face. Regression analysis showed a near‐zero correlation between forces and TDC at all sites.ConclusionThe near‐zero correlation may be due to low skin interstitial hydraulic resistance to mobile water movement in healthy young skin. If true, then conditions in which dermal hydraulic conductance is reduced as in lymphedematous, diabetic, or aged skin are more likely show the hypothesized relationship. Our findings provide normalized reference values and suggest that such persons are an important population to study to test for a possible skin water–indentation force relationship and its utilization for early diagnosis.
Time‐lapse monitoring of soil water content using electromagnetic conductivity imaging
Authors: Huang J. , Scudiero E. , Clary W. , Corwin D. L. , Triantafilis J. 
Published: July 2016

AbstractThe volumetric soil water content (θ) is fundamental to agriculture because its spatiotemporal variation in soil affects the growth of plants. Unfortunately, the universally accepted thermogravimetric method for estimating volumetric soil water content is very labour intensive and time‐consuming for use in field‐scale monitoring. Electromagnetic (EM) induction instruments have proven to be useful in mapping the spatiotemporal variation of θ. However, depth‐specific variation in θ, which is important for irrigation management, has been little explored. The objective of this study was to develop a relationship between θ and estimates of true electrical conductivity (σ) and to use this relationship to develop time‐lapse images of soil θ beneath a centre‐pivot irrigated alfalfa (Medicago sativa L.) crop in San Jacinto, California, USA. We first measured the bulk apparent electrical conductivity (ECa – mS/m) using a DUALEM‐421 over a period of 12 days after an irrigation event (i.e. days 1, 2, 3, 4, 6, 8 and 12). We used EM4Soil to generate EM conductivity images (EMCIs). We used a physical model to estimate θ from σ, accounting for soil tortuosity and pore water salinity, with a cross‐validation RMSE of 0.04 cm3/cm3. Testing the scenario where no soil information is available, we used a three‐parameter exponential model to relate θ to σ and then to map θ along the transect on different days. The results allowed us to monitor the spatiotemporal variations of θ across the surveyed area, over the 12‐day period. In this regard, we were able to map the soil close to field capacity (0.27 cm3/cm3) and approaching permanent wilting point (0.03 cm3/cm3). The time‐lapse θ monitoring approach, developed using EMCI, has implications for soil and water use and management and will potentially allow farmers and consultants to identify inefficiencies in water application rates and use. It can also be used as a research tool to potentially assist precision irrigation practices and to test the efficacy of different methods of irrigation in terms of water delivery and efficiency in water use in near real time.
Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice
Authors: Di Scala Marianna , Otano Itziar , Gil-Fariña Irene , Vanrell Lucia , Hommel Mirja , Olagüe Cristina , Vales Africa , Galarraga Miguel , Guembe Laura , Ortiz de Solorzano Carlos , Ghosh Indrajit , Maini Mala K. , Prieto Jesús , González-Aseguinolaza Gloria 
Published: July 2016

ABSTRACTIn chronic hepatitis B (CHB), failure to control hepatitis B virus (HBV) is associated with T cell dysfunction. HBV transgenic mice mirror many features of the human disease, including T cell unresponsiveness, and thus represent an appropriate model in which to test novel therapeutic strategies. To date, the tolerant state of CD8+T cells in these animals could be altered only by strong immunogens or by immunization with HBV antigen-pulsed dendritic cells; however, the effectors induced were unable to suppress viral gene expression or replication. Because of the known stimulatory properties of alpha interferon (IFN-α) and interleukin-15 (IL-15), this study explored the therapeutic potential of liver-directed gene transfer of these cytokines in a murine model of CHB using adeno-associated virus (AAV) delivery. This combination not only resulted in a reduction in the viral load in the liver and the induction of an antibody response but also gave rise to functional and specific CD8+immunity. Furthermore, when splenic and intrahepatic lymphocytes from IFN-α- and IL-15-treated animals were transferred to new HBV carriers, partial antiviral immunity was achieved. In contrast to previous observations made using either cytokine alone, markedly attenuated PD-L1 induction in hepatic tissue was observed upon coadministration. An initial study with CHB patient samples also gave promising results. Hence, we demonstrated synergy between two stimulating cytokines, IL-15 and IFN-α, which, given together, constitute a potent approach to significantly enhance the CD8+T cell response in a state of immune hyporesponsiveness. Such an approach may be useful for treating chronic viral infections and neoplastic conditions.IMPORTANCEWith 350 million people affected worldwide and 600,000 annual deaths due to HBV-induced liver cirrhosis and/or hepatocellular carcinoma, chronic hepatitis B (CHB) is a major health problem. However, current treatment options are costly and not very effective and/or need to be administered for life. The unprecedented efficacy of the strategy described in our paper may offer an alternative and is relevant for a broad spectrum of readers because of its clear translational importance to other chronic viral infections in which a hyporesponsive antigen-specific T cell repertoire prevents clearance of the pathogen.