bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization
Authors: Hart Emma C. , Head Geoffrey A. , Carter Jason R. , Wallin B. Gunnar , May Clive N. , Hamza Shereen M. , Hall John E. , Charkoudian Nisha , Osborn John W. 
Published: March 2017

Over the past several decades, studies of the sympathetic nervous system in humans, sheep, rabbits, rats, and mice have substantially increased mechanistic understanding of cardiovascular function and dysfunction. Recently, interest in sympathetic neural mechanisms contributing to blood pressure control has grown, in part because of the development of devices or surgical procedures that treat hypertension by manipulating sympathetic outflow. Studies in animal models have provided important insights into physiological and pathophysiological mechanisms that are not accessible in human studies. Across species and among laboratories, various approaches have been developed to record, quantify, analyze, and interpret sympathetic nerve activity (SNA). In general, SNA demonstrates “bursting” behavior, where groups of action potentials are synchronized and linked to the cardiac cycle via the arterial baroreflex. In humans, it is common to quantify SNA as bursts per minute or bursts per 100 heart beats. This type of quantification can be done in other species but is only commonly reported in sheep, which have heart rates similar to humans. In rabbits, rats, and mice, SNA is often recorded relative to a maximal level elicited in the laboratory to control for differences in electrode position among animals or on different study days. SNA in humans can also be presented as total activity, where normalization to the largest burst is a common approach. The goal of the present paper is to put together a summary of “best practices” in several of the most common experimental models and to discuss opportunities and challenges relative to the optimal measurement of SNA across species. Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/guidelines-for-measuring-sympathetic-nerve-activity/
Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes)
Authors: Magvanjav Oyunbileg , McDonough Caitrin W. , Gong Yan , McClure Leslie A. , Talbert Robert L. , Horenstein Richard B. , Shuldiner Alan R. , Benavente Oscar R. , Mitchell Braxton D. , Johnson Julie A. 
Published: March 2017

Background and Purpose—

Functional polymorphisms (Ser49Gly and Arg389Gly) in
ADRB1
have been associated with cardiovascular and β-blocker response outcomes. Herein we examined associations of these polymorphisms with major adverse cardiovascular events (MACE), with and without stratification by β-blocker treatment in patients with a history of stroke.

Methods—
Nine hundred and twenty-six participants of the SPS3 trial’s (Secondary Prevention of Small Subcortical Strokes) genetic substudy with hypertension were included. MACE included stroke, myocardial infarction, and all-cause death. Kaplan–Meier and multivariable Cox regression analyses were used. Because the primary component of MACE was ischemic stroke, we tested the association of Ser49Gly with ischemic stroke among 41 475 individuals of European and African ancestry in the NINDS (National Institute of Neurological Disorders and Stroke) SiGN (Stroke Genetics Network).

Results—

MACE was higher in carriers of the Gly49 allele than in those with the Ser49Ser genotype (10.5% versus 5.4%, log-rank
P
=0.005). Gly49 carrier status was associated with MACE (hazard ratio, 1.62; 95% confidence interval, 1.00–2.68) and ischemic stroke (hazard ratio, 1.81; 95% confidence interval, 1.01–3.23) in SPS3 and with small artery ischemic stroke (odds ratio, 1.14; 95% confidence interval, 1.03–1.26) in SiGN. In SPS3, β-blocker-treated Gly49 carriers had increased MACE versus non–β-blocker-treated individuals and noncarriers (hazard ratio, 2.03; 95% confidence interval, 1.20–3.45). No associations were observed with the Arg389Gly polymorphism.

Conclusion—

Among individuals with previous small artery ischemic stroke, the
ADRB1
Gly49 polymorphism was associated with MACE, particularly small artery ischemic stroke, a risk that may be increased among β-blocker-treated individuals. Further research is needed to define β-blocker benefit among ischemic stroke patients by
ADRB1
genotype.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00059306.
Transnationalism in Missionary Medicine
Authors: Gewurtz Margo S. 
Published: March 2017

Kala-azar is a parasitic disease that was endemic in India, parts of Africa and China. During the first half of the twentieth century, developing means of treatment and identification of the host and transmission vectors for this deadly disease would be the subject of transnational research and controversy. In the formative period for this research, two Canadian Medical missionaries, Drs. Jean Dow and Ernest Struthers, pioneered work on Kala-azar in the North Henan Mission. The great international prestige of the London School of Tropical Medicine and the Indian Medical Service would stand against recognition of the clinical discoveries of missionary doctors in remote North Henan. It was only after Struthers forged personal relations with Dr. Lionel. E. Napier and his colleagues at the Calcutta School of Tropical Medicine that there was a meeting of minds to promote the hypothesis that the sand fly was the transmission vector.
Machine-Learning Algorithms to Code Public Health Spending Accounts
Authors: Brady Eoghan S. , Leider Jonathon P. , Resnick Beth A. , Alfonso Y. Natalia , Bishai David 
Published: March 2017

Objectives: Government public health expenditure data sets require time- and labor-intensive manipulation to summarize results that public health policy makers can use. Our objective was to compare the performances of machine-learning algorithms with manual classification of public health expenditures to determine if machines could provide a faster, cheaper alternative to manual classification. Methods: We used machine-learning algorithms to replicate the process of manually classifying state public health expenditures, using the standardized public health spending categories from the Foundational Public Health Services model and a large data set from the US Census Bureau. We obtained a data set of 1.9 million individual expenditure items from 2000 to 2013. We collapsed these data into 147 280 summary expenditure records, and we followed a standardized method of manually classifying each expenditure record as public health, maybe public health, or not public health. We then trained 9 machine-learning algorithms to replicate the manual process. We calculated recall, precision, and coverage rates to measure the performance of individual and ensembled algorithms. Results: Compared with manual classification, the machine-learning random forests algorithm produced 84% recall and 91% precision. With algorithm ensembling, we achieved our target criterion of 90% recall by using a consensus ensemble of ≥6 algorithms while still retaining 93% coverage, leaving only 7% of the summary expenditure records unclassified. Conclusions: Machine learning can be a time- and cost-saving tool for estimating public health spending in the United States. It can be used with standardized public health spending categories based on the Foundational Public Health Services model to help parse public health expenditure information from other types of health-related spending, provide data that are more comparable across public health organizations, and evaluate the impact of evidence-based public health resource allocation.
The Emergence of an Organizational Field: The Case of Open Source Software
Authors: Ojha Abhoy K , Rao Ravi Anand 
Published: March 2017

Institutional theory offers a very powerful lens to understand and explain societal phenomena. In the context of innovation and technology, this perspective provides insights that complement the understandings derived from a focus on just technology or economics. Adopting this standpoint, this paper examines the emergence of the organizational field of open source software as a response to the norms of propriety software that were unacceptable to many passionate software researchers and programmers. The context of software product development has some unique characteristics that separates it from other industries. First, software products are information goods. In general, information goods have very high fixed costs of development and low marginal costs of reproduction which often leads to market inefficiencies. Second, IP protection has the potential to exaggerate the problem of market inefficiencies. Third, software is an input and also an output of the production function and IP protection has the potential to make the cost of software products prohibitively high. Fourth, the Internet has created the potential for the larger society to participate in the production process. These features of the software industry influence the dynamics among software professionals and orgnizations creating a distinctive context which can be better understood through the lens of institutional theory. According to institution theory, organizations seek to obtain legitimacy, which goes beyond technological or economic performance, by conforming to institutional requirements in a context. There are three forms of legitimacy. Pragmatic legitimacy, based on regulative requirements, is acquired by complying with the legal and regulative rules in the organizational field. Moral legitimacy, based on normative requirements, is obtained by ensuring that the activities of an organization promote societal good or welfare. Finally, cognitive legitimacy is derived from the extent to which the activities of an organization mesh with the taken-for-granted norms in the larger context. While institutions are normally sustained for long, they do experience change. Institutional change is driven by institutional entrepreneurs who create, maintain, and disrupt the practices that are considered legitimate, and challenge the boundaries that demarcate one field from another. The findings of this study capture the intricate dynamics and interactions among institutional requirements, software professionals and organizations that led to the norms of the institution of propriety software being challenged. It suggests that the process of institutional change can lead to the creation of a new alternate organizational field leaving the original field largely untouched. This paper contributes to the understanding of the software industry and suggests implications for other industries that produce information goods.
Safe Drilling Paths in the Distal Femoral Epiphysis for Pediatric Medial Patellofemoral Ligament Reconstruction
Authors: Nguyen Cynthia V. , Farrow Lutul D. , Liu Raymond W. , Gilmore Allison 
Published: March 2017

Background: Anatomic surgical reconstruction of the medial patellofemoral ligament (MPFL) has been popularized for the treatment of recurrent patellar instability in the skeletally immature population. Previous anatomic studies have found that the femoral attachment point of the MPFL is very close to the distal femoral physis. Purpose: To establish the safe angles for drilling the distal femoral epiphysis for MPFL graft placement. Study Design: Descriptive laboratory study. Methods: A total of 23 cadaveric distal femoral epiphyses were scanned into high-resolution 3-dimensional images. Using computer-aided design, we identified and marked the femoral insertion site of the MPFL. Cylinders 8 mm in diameter were placed at varying angles to simulate the drill paths for placement of 6-mm interference screws with a 1-mm buffer. The distance from the MPFL footprint to where the tunnel first violated the physis, the intercondylar notch, or the distal cartilage was measured. We recorded the percentage of tunnels that caused violations before reaching 20 mm, the shortest length of a typical femoral tunnel socket. Results: Measurements indicated that 41% of tunnels angled distally less than 10° violated the physis, 40% of tunnels angled distally more than 10° but anteriorly less than 10° violated the notch, and 27% of tunnels angled distally and anteriorly more than 20° violated the distal femoral cartilage. At least 90% of the tunnels were safe at 20 mm when the drill was angled between 15° and 20° both anteriorly and distally. Conclusion: Because of the anatomy of the distal femoral physis, drilling into the epiphysis from the MPFL attachment site at improper trajectories risks damage to sensitive structures. Angling the drill to an acceptable degree distally and anteriorly leads to less risk to the physis and notch, respectively, but angling too much leads to risk to the distal femoral cartilage. Small variations in the sagittal plane were better tolerated than variations in the coronal plane, so we recommend that more attention be paid to the radiographic anteroposterior view intraoperatively. It is safest to angle the drill distally and anteriorly approximately 15° to 20° in each plane from the MPFL attachment site. Clinical Relevance: During drilling into the distal femoral epiphysis at the MPFL origin in skeletally immature patients, angling the drill appropriately 15° to 20° both distally and anteriorly minimizes damage to the physis, notch, and distal femoral cartilage.
Patellofemoral Kinematics and Tibial Tuberosity–Trochlear Groove Distances in Female Adolescents With Patellofemoral Pain
Authors: Carlson Victor R. , Boden Barry P. , Sheehan Frances T. 
Published: March 2017

Background: Patellofemoral pain (PFP) is a prevalent disorder among female adolescents. Overuse is frequently cited as the cause of pain for this population. What is currently unclear, however, is if the patella demonstrates abnormal tracking patterns relative to the femoral trochlear groove in female adolescents with PFP. Purpose: The aim of this case-control study was to determine if abnormal patellar tracking patterns are present in female adolescents with PFP. The secondary aim was to identify if an increased tibial tuberosity–trochlear groove (TT-TG) distance is associated with the observed kinematic patterns. Study Design: Controlled laboratory study. Methods: Twenty female adolescent knees from 12 patients with PFP and 20 age-matched female knees from 13 healthy controls were recruited for this study. Patellofemoral kinematics (eg, lateral patellar displacement) during a repetitive knee extension-flexion maneuver was quantified by dynamic cine phase-contrast magnetic resonance imaging (MRI). Static MRI scans were used to determine the TT-TG distance. Results: Relative to the control cohort, female adolescents with PFP demonstrated significantly greater lateral displacement at 10° (3.2 mm; P < .001), 20° (2.3 mm; P < .001), and 30° (1.7 mm; P = .014) of knee flexion. A subgroup within this cohort (7 knees from 5 patients) demonstrated extreme lateral maltracking >2 SDs of the mean of the control cohort. This subgroup also demonstrated a greater TT-TG distance relative to the controls (Δ = 4.2 mm; P = .001). Conclusion: This study demonstrates abnormal lateral patellar displacement in the absence of patellar tilt in female adolescents with PFP. Because all adolescents from both cohorts participated in impact sports, it appears that rigorous athletic training alone is inadequate to produce symptoms in this population. Rather, PFP may derive from a combination of physical activity in the context of pathological kinematics. Clinical Relevance: Abnormal patellar tracking patterns and abnormal static alignment have been shown to contribute to the etiology of patellofemoral pain in adults. This study demonstrates that pathologic patellar tracking patterns are present in adolescent females with patellofemoral pain.
Patellofemoral Arthritis After Lateral Patellar Dislocation: A Matched Population-Based Analysis
Authors: Sanders Thomas L. , Pareek Ayoosh , Johnson Nicholas R. , Stuart Michael J. , Dahm Diane L. , Krych Aaron J. 
Published: March 2017

Background: The rate of patellofemoral arthritis after lateral patellar dislocation is unknown. Purpose/Hypothesis: The purpose of this study was to compare the risk of patellofemoral arthritis and knee arthroplasty between patients who experienced a lateral patellar dislocation and matched individuals without a patellar dislocation. Additionally, factors predictive of arthritis after patellar dislocation were examined. The hypothesis was that the rate of arthritis is likely higher among patients who experience a patellar dislocation compared with those who do not. Study Design: Cohort study; Level of evidence, 3. Methods: In this study, 609 patients who had a first-time lateral patellar dislocation between 1990 and 2010 were compared with an age- and sex-matched cohort of patients who did not have a patellar dislocation. Medical records were reviewed to collect information related to the initial injury, recurrent dislocation, treatment, and progression to clinically significant patellofemoral arthritis (defined as symptoms with degenerative changes on patellar sunrise radiographs). Factors associated with arthritis (age, sex, recurrence, osteochondral injury, trochlear dysplasia) were examined. Results: At a mean follow-up of 12.3 ± 6.5 years from initial dislocation, 58 patients (9.5%) in the dislocation cohort were diagnosed with patellofemoral arthritis, corresponding to a cumulative incidence of arthritis of 1.2% at 5 years, 2.7% at 10 years, 8.1% at 15 years, 14.8% at 20 years, and 48.9% at 25 years. In the control cohort, 8 patients (1.3%) were diagnosed with arthritis, corresponding to a cumulative incidence of arthritis of 0% at 5 years, 0% at 10 years, 1.3% at 15 years, 2.9% at 20 years, and 8.3% at 25 years. Therefore, patients who experienced a lateral patellar dislocation had a significantly higher risk of developing arthritis (hazard ratio [HR], 7.8; 95% CI, 3.9-17.6; P < .001) than individuals without a patellar dislocation. However, the risk of knee arthroplasty was similar between groups (HR, 2.8; 95% CI, 0.6-19.7; P = .2). Recurrent patellar dislocations (HR, 4.5; 95% CI, 1.6-12.6), osteochondral injury (HR, 11.3; 95% CI, 5.0-26.6), and trochlear dysplasia (HR, 3.6; 95% CI, 1.3-10.0) were associated with arthritis after patellar dislocation. Conclusion: Patellar dislocation is a significant risk factor for patellofemoral arthritis, as nearly half of patients have symptoms and radiographic changes consistent with arthritis at 25 years after lateral patellar dislocation. Osteochondral injury, recurrent patellar instability, and trochlear dysplasia are associated with the development of arthritis.
Omega-3-Fortified Lipid-Based Nutrient Supplement: Development, Characterization, and Consumer Acceptability
Authors: Gaur Shashank , Sloffer Elizabeth M. , Ojha Ankur , Patra Falguni , Shukla Dharmendra , Engeseth Nicki J. , Patel Pramthesh R. , Andrade Juan E. 
Published: March 2017

Background: Incorporation of omega-3 polyunsaturated fatty acid (PUFA) sources to lipid-based nutrition supplement (LNS) formulations for undernourished populations presents a challenge due to reduced shelf life and poor consumer acceptability. Objective: To systematically develop an omega-3-fortified LNS formulation, using flaxseed oil (FO), by optimizing its processing stability and evaluating its sensory acceptance. Methods: LNS formulations were formulated to yield approximately 452 kcal, 13.2 g of protein, 30 g of fat, and 53 g of carbohydrates per 100 g. Response surface methodology (RSM) with 4-factor-3-level: omega-3 fatty acid source (FO; 0%-10%), antioxidant (ascorbyl palmitate: 0.0%-0.03%), emulsifier (soy lecithin: 0.5%-1.5%), and storage time (0-6 months at 40°C) was used to optimize LNS’s functionality and storage stability. Factor effects were evaluated for peroxide value, oil separation, water activity, moisture content, hardness, and vitamin C content of the samples. Consumer acceptability was assessed using a 9-point hedonic scale. Results: After 6 months of accelerated storage, the addition of FO to LNS formula resulted in increased peroxide values (7.75 mEq/kg fat) and lipid separation and a reduction in vitamin C and water activity. Optimal levels to maximize storage time and FO and minimize oxidation were 0.02% antioxidant, 1.5% emulsifier, and 4.9% FO. Indian women and students accepted LNS formulations with or without FO similar to other commercial supplements. Conclusion: An LNS containing FO with improved omega-6/omega-3 PUFA ratio was successfully formulated with staple Indian ingredients and optimized for storage stability using RSM.
Validation de la version française de l’échelle multidimensionnelle des conduites de négligence parentale
Authors: Clément Marie-Ève , Bérubé Annie , Chamberland Claire 
Published: March 2017

Objectif: La mesure de la négligence parentale pose de nombreux défis et il existe encore peu d’outil capable de la documenter auprès des parents. L’étude vise à documenter les propriétés psychométriques de la traduction française de la version brève de l’Échelle multidimensionnelle des conduites de négligence parentale dans la population générale. Méthode: Cette étude utilise les données d’une enquête téléphonique réalisée auprès d’un échantillon représentatif de 3584 mères et 1202 pères d’enfants âgés entre 6 mois-4 ans, 5-9 ans et 10-15 ans. Des liens sont établis entre la négligence et plusieurs autres facteurs connus pour leurs liens avec la problématique, dont les conduites parentales à caractère violent, le stress lié au tempérament perçu difficile de l’enfant et à la conciliation travail-famille, la consommation d’alcool et de drogues, les symptômes de dépression, la pauvreté, et le soutien social. Résultats: Les analyses factorielles exploratoires montrent la présence de diverses dimensions de la négligence concernant les besoins affectifs/cognitifs, physiques (soins de base) et de supervision des enfants. Bien que les dimensions soient étroitement associées aux facteurs de vulnérabilité psychosociale des enfants et des familles, les coefficients de cohérence interne sont faibles, variant entre 0,20 et 0,64. Conclusion: Des recommandations sont émises pour améliorer la mesure dans la population générale, et notamment la dimension de supervision parentale qui pose des défis particuliers.
Comorbidities Might Condition the Recovery of Quality of Life in Survivors of Sepsis
Authors: Erbs Gislene C. , Mastroeni Marco F. , Pinho Mauro S. L. , Koenig Álvaro , Sperotto Geonice , Ekwaru John Paul , Westphal Glauco A. 
Published: March 2017

Purpose: To assess how preexisting disabling comorbidities (DC) affect the recovery rate of quality of life (QOL) over time in sepsis survivors. Methods: A prospective study was conducted on sepsis survivors who answered the 36-Item Short Form Health Survey (SF-36) 7 days after discharge from the intensive care unit. Subsequent interviews were held at 3, 6, and 12 months. The results of the physical component score (PCS) and mental component score (MCS) of the SF-36 were evaluated. Patients were divided into 2 groups to compare patients with DC (DC group) and without DC (no-DC group). Quantile regression was used to model changes in PCS and MCS between different time points. Results: Seventy-nine sepsis survivors were enrolled. After controlling for baseline age and QOL, the QOL scores were lower among patients with DC than in no-DC patients. The QOL of DC group got worse when compared to no-DC group. Recovery rate of PCS and MCS was higher in the DC group than in the no-DC group (PCS: 20.51 vs 16.96, P < .01; MCS: 19.24 vs 9.66, P < .01). Their baseline QOL was recovered only by 6 months after the sepsis episode. Conclusion: Quality-of-life impairment and its recovery rhythm in patients with sepsis appear to be conditioned by coexisting DC.