bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cluster-analytical approach toward real-world outcome in outpatients with stable schizophrenia
Authors: Rocca P. , Montemagni C. , Mingrone C. , Crivelli B. , Sigaudo M. , Bogetto F. 
Published: January 2016

AbstractBackgroundThis study aims to empirically identify profiles of functioning, and the correlates of those profiles in a sample of patients with stable schizophrenia in a real-world setting. The second aim was to assess factors associated with best profile membership.MethodsThree hundred and twenty-three outpatients were enrolled in a cross-sectional study. A two-step cluster analysis was used to define groups of patients by using baseline values for the Heinrichs-Carpenter Quality of Life Scale (QLS) total score. Logistic regression was used to construct models of class membership.ResultsOur study identified three distinct clusters: 50.4% of patients were classified in the “moderate” cluster, 27.9% in the “poor” cluster, 21.7% in the “good” cluster. Membership in the “good” cluster versus the “poor” cluster was characterized by less severe negative (OR = .832) and depressive symptoms (OR = .848), being employed (OR = 2.414), having a long-term relationship (OR = .256), and treatment with second-generation antipsychotics (SGAs) (OR = 3.831). Nagelkerke R2 for this model was .777.ConclusionsUnderstanding which factors are associated with better outcomes may direct specific and additional therapeutic interventions, such as treatment with SGAs and supported employment, in order to enhance benefits for patients, as well as to improve the delivery of care in the community.
The Relationship Among Neuromuscular Impairments, Chronic Back Pain, and Mobility in Older Adults
Authors: Makris Una E. , Paul Tracy M. , Holt Nicole E. , Latham Nancy K. , Ni Pengsheng , Jette Alan , Leveille Suzanne G. , Bean Jonathan F. 
Published: January 2016

AbstractBackgroundFor older adults with mobility problems, one focus of rehabilitation is treating the underlying neuromuscular impairment(s) that lead to functional decline and disability. Knowing which neuromuscular impairments contribute to basic mobility tasks among older adults with back pain will fill an important knowledge gap and is a critical step towards developing mechanistically based rehabilitative interventions.ObjectiveTo evaluate the relationship of neuromuscular impairments with performance of mobility tasks among older adults with and without back pain.DesignCross‐sectional analysis of baseline data from the Boston Rehabilitative Impairment Study of the Elderly.SettingPrimary care−based population.PatientsParticipants (N = 430) were older primary care patients who completed assessments of neuromuscular impairments and mobility tasks.MethodsBack pain was assessed by the use of an established comorbidity questionnaire. Neuromuscular impairments included trunk extensor muscle endurance, kyphosis, leg strength, leg strength asymmetry, leg speed, mean reaction time, leg coordination, and knee and ankle range of motion.Main Outcome MeasurementsMobility tasks included gait speed, standing balance, chair stand, and patient‐reported functional status. Analysis of covariance was used to generate adjusted means for neuromuscular impairments that differed significantly by back pain status. Separate multivariable regression models evaluated the association between neuromuscular impairments and mobility based on back pain status after we adjusted for sociodemographic factors and physiologic impairments.ResultsParticipants had an average age of 77 years, 68% were female, and 31% reported back pain. Trunk extensor muscle endurance, leg strength, and rapid leg coordination were significantly lower among those with back pain compared to those without (P < .01, P = .01, P = .04, respectively). Patterns of neuromuscular impairments that were associated with mobility tasks differed according to back pain status.ConclusionsThe neuromuscular impairment profiles associated with mobility function among older adults with back pain vary compared with older adults without back pain.
Quality of Life, Cognition and Mood in Adults with Pediatric Multiple Sclerosis
Authors: Krysko Kristen M. , O’Connor Paul 
Published: January 2016

AbstractBackground: Pediatric onset multiple sclerosis (MS) negatively affects cognitive function, mood and health related quality of life (HRQOL). We aimed to explore the cognitive, psychological and HRQOL impacts of pediatric MS on young adults and to explore the relationships between disability, disease duration, cognition, mood and HRQOL in this hypotheses generating study. Methods: Thirty-four young adults with pediatric onset MS at St. Michael’s Hospital in Toronto were included in this cross-sectional study (mean age 21.3 years, 56% female). Participants completed assessments of physical disability (Expanded Disability Status Scale (EDSS)), cognitive function (Symbol Digit Modalities Test (SDMT)), mood (Beck Depression Inventory II (BDI-II)), and HRQOL (Short Form Health Survey (SF-36v2)). Findings were compared to age- and gender- matched normative data. Results: Individuals with pediatric MS performed worse on the SDMT compared to normative data, with 53% demonstrating cognitive impairment. There was no difference in BDI-II scores from normative data, but 21% showed at least mild depression. There was a non-significant impairment in physical HRQOL compared to normative data. Decreased physical HRQOL was related to disability (EDSS), while mental HRQOL was related to depression (BDI-II). Conclusions: Young adults with pediatric MS have reduced cognitive function. Non-significant reductions in HRQOL may be partly attributed to physical disability and depression. These factors should be addressed in the care of adults with pediatric MS. Further studies including control groups and longitudinal design are needed to confirm these findings.
Disaster Preparedness in Rural Families of Children With Special Health Care Needs
Authors: Hamann Cara J. , Mello Elizabeth , Wu Hongqian , Yang Jingzhen , Debra Waldron  , Ramirez Marizen 
Published: January 2016

AbstractObjectiveThe purpose of this study was to describe disaster preparedness strategies and behaviors among rural families who have children with special health care needs and to examine the effect of self-efficacy and response-efficacy on disaster preparedness.MethodsData for this study were drawn from the baseline surveys of 287 rural families with children with special health care needs who were part of a randomized controlled trial examining the impact of an intervention on disaster preparedness. Distributions of child, parent, and family characteristics were examined by preparedness. Linear regression models were built to examine the impact of self-efficacy and response-efficacy on level of disaster preparedness.ResultsDisaster preparedness (overall, emergency plan, discussion/practice, and supplies) was low (40.9-69.7%) among study families. Disaster preparedness was found to increase with each unit increase in the level of self-efficacy and family resilience sources across all 4 categories of preparedness.ConclusionsDisaster preparedness among rural families with children with special health care needs is low, which is concerning because these children may have increased vulnerability to adverse outcomes compared to the general population. Results suggest that increasing the levels of self-efficacy and family resilience sources may increase disaster preparedness. (Disaster Med Public Health Preparedness. 2016;10:225–232)
Acquisition of Clostridium difficile on Hands of Healthcare Personnel Caring for Patients with Resolved C. difficile Infection
Authors: Shrestha Subarna K. , Sunkesula Venkata C.K. , Kundrapu Sirisha , Tomas Myreen E. , Nerandzic Michelle M. , Donskey Curtis J. 
Published: January 2016

In an observational study, we found that healthcare personnel frequently acquired Clostridium difficile on their hands when caring for patients with recently resolved C. difficile infection (CDI) (<6 weeks after treatment) who were no longer under contact precautions. Continuing contact precautions after diarrhea resolves may be useful to reduce transmission.Infect. Control Hosp. Epidemiol. 2016;37(4):475–477
The impact of focus particles on the recognition and rejection of contrastive alternatives
Authors: GOTZNER NICOLE , WARTENBURGER ISABELL , SPALEK KATHARINA 
Published: January 2016

abstractThe semantics of focus particles likeonlyrequires a set of alternatives (Rooth, 1992). In two experiments, we investigated the impact of such particles on the retrieval of alternatives that are mentioned in the prior context or unmentioned. The first experiment used a probe recognition task and showed that focus particles interfere with the recognition of mentioned alternatives and the rejection of unmentioned alternatives relative to a condition without a particle. A second lexical decision experiment demonstrated priming effects for mentioned and unmentioned alternatives (compared with an unrelated condition) while focus particles caused additional interference effects. Overall, our results indicate that focus particles trigger an active search for alternatives and lead to a competition between mentioned alternatives, unmentioned alternatives, and the focused element.
The effect of diet on the physical and mental development of children: views of parents and teachers in four European countries
Authors: Egan Bernadette , Gage Heather , Williams Peter , Brands Brigitte , Györei Eszter , López-Robles Juan-Carlos , Campoy Cristina , Decsi Tamas , Koletzko Berthold , Raats Monique 
Published: January 2016

AbstractAlthough the impact of diet on physical health is an important public health issue, less attention has been devoted to the relationship between nutrition and children’s mental development. The views of parents and teachers about the extent to which diet affects physical and mental development of children were compared in four European countries. An online questionnaire (developed in English and translated) was circulated through a market research agency. Participants were parents or teachers of children aged 4–10 years without learning or behavioural issues. Questionnaires were returned by 1606 parents (401 in England, Germany and Hungary; 403 in Spain) and 403 teachers (100 in each country, except for 103 in Hungary). Teachers were older than parents (35·3 % v. 18·3 % over 45 years; P<0·001) and less likely to smoke (15·9 % v. 26·3 %, P<0·001). There was no difference between the proportions of parents and teachers who felt that a child’s physical development depended very much/extremely (v. moderately/slightly/not at all) on diet (overall 79·8 %). Lower proportions of both groups thought that mental development was very much/extremely influenced by diet (67·4 %). In the regression modelling, believing that physical and mental performance was greatly influenced by diet was significantly and positively associated with living in Hungary, scoring higher on a measure of General Health Interest and (parents only) level of education attained. Differences existed among countries in most views. Lower levels of awareness of the importance of diet for brain development and cognition (compared with physical health outcomes) indicate the potential for educating consumers, especially parents with lower educational attainment.
Prenatal folate, homocysteine and vitamin B12 levels and child brain volumes, cognitive development and psychological functioning: the Generation R Study
Authors: Ars Charlotte L. , Nijs Ilse M. , Marroun Hanan E. , Muetzel Ryan , Schmidt Marcus , Steenweg-de Graaff Jolien , van der Lugt Aad , Jaddoe Vincent W. , Hofman Albert , Steegers Eric A. , Verhulst Frank C. , Tiemeier Henning , White Tonya 
Published: January 2016

AbstractPrevious studies have suggested that prenatal maternal folate deficiency is associated with reduced prenatal brain growth and psychological problems in offspring. However, little is known about the longer-term impact. The aims of this study were to investigate whether prenatal maternal folate insufficiency, high total homocysteine levels and low vitamin B12 levels are associated with altered brain morphology, cognitive and/or psychological problems in school-aged children. This study was embedded in Generation R, a prospective population-based cohort study. The study sample consisted of 256 Dutch children aged between 6 and 8 years from whom structural brain scans were collected using MRI. The mothers of sixty-two children had insufficient (<8 nmol/l) plasma folate concentrations in early pregnancy. Cognitive development was assessed by the Snijders-Oomen Niet-verbale intelligentietest – Revisie and the NEPSY-II-NL. Psychological problems were assessed at age 6 years using the parent report of the Child Behavior Checklist. Low prenatal folate levels were associated with a smaller total brain volume (B –33·34; 95 % CI –66·7, 0·02; P=050) and predicted poorer performance on the language (B –0·28; 95 % CI –0·52, –0·04; P=0·020) and visuo-spatial domains (B –0·27; 95 % CI –0·50, –0·04; P=0·021). High homocysteine levels (>9·1 µmol/l) predicted poorer performance on the language (B –0·31; 95 % CI –0·56, –0·06; P=0·014) and visuo-spatial domains (B –0·36; 95 % CI –0·60, –0·11; P=0·004). No associations with psychological problems were found. Our findings suggest that folate insufficiency in early pregnancy has a long-lasting, global effect on brain development and is, together with homocysteine levels, associated with poorer cognitive performance.
Basement-involved thin-skinned and thick-skinned tectonics in the Alps
Authors: PFIFFNER O. ADRIAN 
Published: January 2016

AbstractThe deformation of continental crust during continental collision by folding and thrusting follows three types of structural styles: (1) in a true thin-skinned style only cover rocks are involved; (2) in the case of a thin-skinned basement-involved style, thin slabs of crystalline basement rocks are piled up into a nappe stack; (3) in a true thick-skinned style, the entire upper crust is involved in the deformation. In the Alps all three styles can be recognized. The Helvetic nappes and parts of the Penninic nappes exhibit true thin-skinned style tectonics. Triassic evaporites, Jurassic shales and Cretaceous marls acted as detachment horizons. Basement-involved thin-skinned tectonics is typical for the Penninic nappes in the core of the orogen. The thickness of the basement thrust sheets is controlled by the effects of Mesozoic rifting, by deep burial and heating of the subducting crust and by the presence of Late Palaeozoic structures. Thick-skinned style is observed in the more external parts of the orogen, the external massifs and the Southalpine nappe system. It occurred in the late phase of collision and involved the entire upper crust. The basal detachment occurred possibly along phyllonites generated by the breakdown of load-bearing feldspar. Considering the Alpine orogen as a whole, the lower crust deformed seemingly independently from the upper crust. The detachment of the cover units by thin-skinned tectonics occurred prior to thrusting related to basement-involved thin-skinned tectonics. Thrust faults of both types were overprinted by ‘post-nappe folding’.
THE ELECTORAL DYNAMICS OF CONSERVATISM, 1885–1910: ‘NEGATIVE UNIONISM’ RECONSIDERED
Authors: BLAXILL LUKE , SALEH TAYM 
Published: January 2016

ABSTRACTThis article takes a fresh look at the long-running debate on whether the Unionist party owed its electoral success between the Third Reform Act and the Great War predominantly to ‘negative’ factors: principally, low turnout; poor Liberal organization; and a reliable and consistent middle-class vote. Taking advantage of recently digitized election datasets, it conducts the most extensive statistical study thus far attempted, to argue that recent revisionist historians have dismissed too readily the traditional ‘negative Unionism’ thesis associated with J. P. Cornford. It conducts an extensive analysis of the relationship between turnout and Unionist support on national, constituency, and regional levels, and finds that the much-disputed traditional interpretation that Conservatives benefited from low polls in the late Victorian period is broadly borne out in England. Additionally, this article also investigates the wider impact of uncontested constituencies in this period, arguing that the large number of seats left unfought by the Liberals was even more electorally grievous than the raw numbers imply. Both these findings suggest that the Unionists benefited from a still more substantial structural advantage in the late Victorian period than historians have previously assumed. While important aspects of Unionist language and strategy were undoubtedly positive, they were nonetheless underpinned by negative electoral foundations.
THE DYNAMICS AND DETERMINANTS OF SLAVE PRICES IN AN URBAN SETTING: SANTIAGO DE CHILE,c. 1773-1822
Authors: Cussen Celia , Llorca-Jaña Manuel , Droller Federico 
Published: January 2016

ABSTRACTThis paper provides the first survey of slave prices for Santiago de Chile,c. 1773-1822. It also establishes the main determinants of slave prices during this period. We gathered and analysed over 3,800 sale operations. Our series confirm the usual inverted U-shape when prices are plotted against age, and that age was a very important determinant of slave prices. We also found that: female slaves were systematically priced over male slaves, quite contrary to what happened in most other markets; the prime age of Santiago slaves was 16-34, a younger range than for most other places; male slave prices moved in the same direction as real wages of unskilled workers; and the impact of the free womb law on market prices in 1811 was dramatic.
Neuropsychological Practice Effects in the Context of Cognitive Decline: Contributions from Learning and Task Novelty
Authors: Thorgusen Sommer R. , Suchy Yana , Chelune Gordon J. , Baucom Brian R. 
Published: January 2016

AbstractAlthough cognitive decline is typically associated with decreasing practice effects (PEs) (presumably due to declining memory), some studies show increased PEs with declines in cognition. One explanation for these inconsistencies is that PEs reflect not only memory, but also rebounds from adapting to task novelty (i.e., novelty effect), leading to increased PEs. We examined a theoretical model of relationships among novelty effects, memory, cognitive decline, and within-session PEs. Sixty-six older adults ranging from normal to severely impaired completed measures of memory, novelty effects, and two trials each of Wechsler Adult Intelligence Scale, 4thEdition Symbol Search and Coding. Interrelationships among variables were examined using regression analyses. PEs for Symbol Search and Coding (a) were related to different proposed PE components (i.e., memory and novelty effects), such that novelty effect predicted Symbol Search PE (R2=.239, p<.001) and memory predicted Coding PE (R2=.089, p=.015), and (b) showed different patterns across stages of cognitive decline, such that the greatest cognitive decline was associated with smallest Coding PE (R2=.125, p=.004), whereas intermediate cognitive decline was associated with the greatest Symbol Search PE (R2=.097, p=.040). The relationship between cognitive decline and PE for Symbol Search was partially mediated by novelty effect among older adults with abnormal cognitive decline (model R2=.286, p<.001). These findings (a) suggest that PE is not a unitary construct, (b) offer an explanation for contradictory findings in the literature, and (c) highlight the need for a better understanding of component processes of PE across different neuropsychological measures. (JINS, 2016, 22, 453–466)
Resveratrol and STAT inhibitor enhance autophagy in ovarian cancer cells
Authors: Zhong L-X , Zhang Y , Wu M-L , Liu Y-N , Zhang P , Chen X-Y , Kong Q-Y , Liu J , Li H 
Published: January 2016

AbstractAutophagic activity reflects cellular response to drug treatment and can be regulated by STAT3 signaling. Resveratrol inhibits STAT3 activation and causes remarkable growth arrest and cell death of ovarian cancer (OC) cells. However, the autophagic status and its relevance with resveratrol’s anti-OC effects remain unclear. We analyzed the states of autophagic activities, the nature of autophagosomes and the levels of autophagy-related proteins (LC-3, Beclin 1 and STAT3) in resveratrol-treated CAOV-3 and OVCAR-3 OC cells using multiple approaches. We elucidated the correlation of STAT3 inhibition with autophagic activity by treating OC cells with an upstream inhibitor of STAT proteins, AG490. Resveratrol efficiently suppressed growth, induced apoptosis and inactivated STAT3 signaling of the two OC cell lines. We found enhanced autophagic activity accompanied with Beclin-1 upregulation and LC3 enzymatic cleavage in resveratrol-treated OC cells. Immunofluorescent (IF) microscopic and IF-based confocal examinations demonstrated the accumulation of cytoplasmic granules co-labeled with LC3 and cytochrome C in resveratrol- or AG490-treated OC cells. Using electron microscopy, we confirmed an increase in autophagosomes and mitochondrial spheroids in either resveratrol- or AG490-treated OC cells. This study demonstrates the abilities of resveratrol to enhance apoptotic and autophagic activities in OC cells, presumably via inactivating STAT3 signaling. Resveratrol or the selective JAK2 inhibitor also leads to mitochondrial turnover, which would be unfavorable for OC cell survival and sensitize OC cells to resveratrol.
Genetic basis for glandular trichome formation in cotton
Authors: Ma Dan , Hu Yan , Yang Changqing , Liu Bingliang , Fang Lei , Wan Qun , Liang Wenhua , Mei Gaofu , Wang Lingjian , Wang Haiping , Ding Linyun , Dong Chenguang , Pan Mengqiao , Chen Jiedan , Wang Sen , Chen Shuqi , Cai Caiping , Zhu Xiefei , Guan Xueying , Zhou Baoliang , Zhu Shuijin , Wang Jiawei , Guo Wangzhen , Chen Xiaoya , Zhang Tianzhen 
Published: January 2016

AbstractTrichomes originate from epidermal cells and can be classified as either glandular or non-glandular. Gossypium species are characterized by the presence of small and darkly pigmented lysigenous glands that contain large amounts of gossypol. Here, using a dominant glandless mutant, we characterize GoPGF, which encodes a basic helix-loop-helix domain-containing transcription factor, that we propose is a positive regulator of gland formation. Silencing GoPGF leads to a completely glandless phenotype. A single nucleotide insertion in GoPGF, introducing a premature stop codon is found in the duplicate recessive glandless mutant (gl2gl3). The characterization of GoPGF helps to unravel the regulatory network of glandular structure biogenesis, and has implications for understanding the production of secondary metabolites in glands. It also provides a potential molecular basis to generate glandless seed and glanded cotton to not only supply fibre and oil but also provide a source of protein for human consumption.