bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceso a la justicia de sectores especialmente vulnerables en el Programa Nacional de Casas de Justicia y Paz
Authors: Fajardo Luis Alfonso 
Published: October 2016

<h2>1. PLANTEAMIENTO DEL PROBLEMA</h2><p><strong> </strong></p><p><strong>1.1 El acceso a la justicia en Colombia</strong><strong></strong></p><p><strong> </strong></p>Durante las últimas décadas, en Colombia el sistema de administración de justicia ha sufrido un proceso de deslegitimación creciente generado por distintos factores, como la congestión, el retardo en la resolución de los asuntos, el exceso de procesalismo, los fenómenos de corrupción, las presiones externas, etc. lo cual viene generando, como consecuencia, formas de injusticia y exclusión. Las comunidades más vulnerables de la población colombiana constantemente se encuentran frente a la violación de sus derechos fundamentales y garantías constitucionales, sin los medios para poder acudir al apoyo del Estado, el cual debería ser garante de aquéllos. La Constitución Política, en su art. 229, “garantiza el derecho de toda persona para acceder a la administración de justicia”. En desarrollo de este derecho, distintos gobiernos han impulsado el Programa Nacional de Casas de Justicia, estableci- mientos creados para el servicio precisamente de aquellos sectores que, por sus condiciones sociales, económicas o culturales, tienen un acceso restringido al aparato de justicia estatal.
El concepto de derecho. Foucault, la ley y la crítica del paradigma liberal
Authors: MIELES ERNESTO 
Published: October 2016

<p>En 1966 Michel Foucault creía que la ley era omni- presente. En <em>El pensamiento del afuera</em>, corto es- crito en el cual examinó la obra de Blanchot desde la perspectiva inaugurada por <em>Las palabras y las cosas</em>, sostuvo que “la ley, soberanamente, asedia las ciudades, las instituciones, las conductas y los gestos; se haga lo que se haga, por grandes que sean el desorden y la incuria, ella ya ha desplega- do sus poderes” (p. 44).</p><p> </p><p>Menos de diez años después, en <em>Vigilar y castigar</em>, el filósofo francés habría de cambiar de posición. En esta obra sostendría el fin del derecho, o más exactamente, el fin del paradigma teórico jurídico liberal, de acuerdo con el cual el derecho es el principal instrumento de regulación y normaliza- ción de las sociedad modernas.</p>
«Sobre el análisis cultural del derecho», Koyaanisqatsi1 La desinencia de la DIOS-a madre
Authors: VALENCIA DAVID 
Published: October 2016

<div class="WordSection1"><p>“Hoy mi tema será la mujer”2 , porque la mujer no es tematizable, la materia de ésta conferencia, la materia modular, la materia <em>a</em>3 modular, a transfor- mar, crear, ductilizar, manipular, moldear, madu- rar, acomodar, <em>perspectivizar</em><em>4</em><em> </em>desde los valores del centro de interés, para diseñar un curso de acción plausible, una manera de hacer las cosas, consoli- dar un estilo, el eje temático como soporte de lo que se dice (sin saber lo que está diciendo y aún ignorando eso), el <em>eterno femenino</em><em> </em>de Goethe, que no es eterno ni mucho menos, se parece a mujer alguna, no se parece nada, hace <em>como</em><em> </em><em>si </em>se aseme- jara, pero carece de modelo. La mujer como mo-</p><br clear="all" /><p>delo, modela al ser vivo en su vientre, pero tam- bién desfila en la pasarela (no aparecen las chicas águila), <em>pensar las cosas así</em>, sin referente metafísi- co, “con imagen sin semejanza”, viniendo todos de ella, Gaia, Tiamat, el caos reptante, Tánit, Astarté, Innana, Isis, Artemis la diademaza, Afrodita, Juno, Atenea Negra, la Virgen de las putas tristes, Coatlicue, faldellín de estrellas. Es la materia de la que se habla, de mater: madre, la virgen lacrimosa, en éste valle de lágrimas, pero también el asunto, el objeto de la investigación: <em>sólo la mujer es mi tema</em>.</p></div>
Los invisibles en el laberinto del minotauro o la lucha por el derecho a la justicia en Colombia
Authors: FAJARDO SÁNCHEZ LUIS ALFONSO 
Published: October 2016

<p>El artículo establece un análisis de nuestra realidad sociopolítica y las necesidades de acceso a la justicia de los sectores menos favorecidos de nuestro país, sectores que luchan por lograr una justicia pronta y material; en su reflexión el autor recoge el Programa Nacional de Casas de Justicia, política pública creada en el por el decreto 1477 del 2000 con el fin de facilitar a las comunidades de menores recursos el acceso a la justicia, y lo relaciona con necesidades concretas de los grupos étnicos, los habitantes de la calle, los adultos mayores y los desplazados.</p><p> </p>
Complejidad, conflictos, justicia
Authors: FAJARDO SÁNCHEZ LUIS ALFONSO , García Lozano Luisa Fernanda 
Published: October 2016

<p>El presente ensayo intenta verificar el impacto del Instituto Internacional de Sociología Jurídica - IISJ en el desarrollo y la consolidación de la sociología jurídica en nuestro país, a partir de tres momentos en los que se discutieron aspectos teóricos y conceptuales de la realidad americana.</p><p> </p><p>Las tendencias de las investigaciones sociojurídicas en América Latina reflejan algunos ejes vertebrales temáticos desde sus comienzos, como: Teoría sociojurídica; Uso alternativo del derecho; Los servicios legales alternativos: derechos humanos; Formas de derecho propio; Pluralismo jurídico; La globalización; Mecanismos alternativos de resolución de conflictos; Problemas de género y La enseñanza jurídica. Las perspectivas con las que se han abordado estos temas se han modificado a través del tiempo, sin embargo, se encuentra una constante: una trasformación social en torno a un derecho emancipatorio incluyente.</p><p> </p><p>Tomaremos para el presente ensayo, tres momentos:</p><ol><li><em>Workshop en el IISJ </em>existe alguna especificidad en la sociología jurídica en América Latina? 1990.</li><li><em>Workshop en el </em><em>IISJ. </em>La Sociología Jurídica en América Latina. 2002.</li><li><em>Congreso</em><em> </em><em>Latinoamericano de </em><em>Sociología </em><em>Jurídica. </em><em>Derecho </em><em>y </em><em>Liberación. IISJ 2007</em></li></ol>
¡Beccaria está preso en la Cárcel Distrital! Un estudio de caso sobre el “estado de cosas inconstitucional” en las cárceles
Authors: FAJARDO SÁNCHEZ LUIS ALFONSO , CAMELO HEYDER ALFONSO 
Published: October 2016

<p>El sistema carcelario, como espacio de castigo y cumplimiento de penas por delitos cometidos, es el esce- nario en el cual el poder del Estado se ejerce de manera visible y con legitimidad plena en sus acciones. Este hecho configura una amenaza constante a la protección y disfrute de los derechos de las personas allí recluidas, las cuales son leídas como ciudadanos de segunda clase, donde todas sus penas y sufrimientos son “justos” como resultado de sus acciones en contra del orden social establecido.</p><p> </p><p>La Cárcel Distrital no escapa de estas lógicas, y se configura en una institución totalitaria, donde los derechos humanos de las personas recluidas quedan virtualmente suspendidos mientras cumplen sus penas. Este documento pretende llamar la atención sobre quienes allí se encuentran, mostrando una radiografía de su realidad y cómo a pesar de existir una serie de instrumentos internacionales encaminada a la protección de sus derechos, fallos de estados de cosas inconstitucional por parte de la Honorable Corte Constitu- cional, las condiciones de los internos e internas no hacen parte de la agenda pública y política del país.</p>
Comprehensive Cross-Population Analysis of High-Grade Serous Ovarian Cancer Supports No More Than Three Subtypes
Authors: Way Gregory P , Rudd James , Wang Chen , Hamidi Habib , Fridley Brooke L , Konecny Gottfried E , Goode Ellen L , Greene Casey S , Doherty Jennifer A 
Published: October 2016

Abstract
Four gene expression subtypes of high-grade serous ovarian cancer (HGSC) have been previously described. In these early studies, a fraction of samples that did not fit well into the four subtype classifications were excluded. Therefore, we sought to systematically determine the concordance of transcriptomic HGSC subtypes across populations without removing any samples. We created a bioinformatics pipeline to independently cluster the five largest mRNA expression datasets using k-means and nonnegative matrix factorization (NMF). We summarized differential expression patterns to compare clusters across studies. While previous studies reported four subtypes, our cross-population comparison does not support four. Because these results contrast with previous reports, we attempted to reproduce analyses performed in those studies. Our results suggest that early results favoring four subtypes may have been driven by the inclusion of serous borderline tumors. In summary, our analysis suggests that either two or three, but not four, gene expression subtypes are most consistent across datasets.
Analysis of alin-42/periodNull Allele Implicates All Three Isoforms in Regulation ofCaenorhabditis elegansMolting and Developmental Timing
Authors: Edelman Theresa L B , McCulloch Katherine A , Barr Angela , Frøkjær-Jensen Christian , Jorgensen Erik M , Rougvie Ann E 
Published: October 2016

AbstractThe Caenorhabditis elegans heterochronic gene pathway regulates the relative timing of events during postembryonic development. lin-42, the worm homolog of the circadian clock gene, period, is a critical element of this pathway. lin-42 function has been defined by a set of hypomorphic alleles that cause precocious phenotypes, in which later developmental events, such as the terminal differentiation of hypodermal cells, occur too early. A subset of alleles also reveals a significant role for lin-42 in molting; larval stages are lengthened and ecdysis often fails in these mutant animals. lin-42 is a complex locus, encoding overlapping and nonoverlapping isoforms. Although existing alleles that affect subsets of isoforms have illuminated important and distinct roles for this gene in developmental timing, molting, and the decision to enter the alternative dauer state, it is essential to have a null allele to understand all of the roles of lin-42 and its individual isoforms. To remedy this problem and discover the null phenotype, we engineered an allele that deletes the entire lin-42 protein-coding region. lin-42 null mutants are homozygously viable, but have more severe phenotypes than observed in previously characterized hypomorphic alleles. We also provide additional evidence for this conclusion by using the null allele as a base for reintroducing different isoforms, showing that each isoform can provide heterochronic and molting pathway activities. Transcript levels of the nonoverlapping isoforms appear to be under coordinate temporal regulation, despite being driven by independent promoters. The lin-42 null allele will continue to be an important tool for dissecting the functions of lin-42 in molting and developmental timing.
Genome-Wide Association Study and QTL Mapping Reveal Genomic Loci Associated withFusariumEar Rot Resistance in Tropical Maize Germplasm
Authors: Chen Jiafa , Shrestha Rosemary , Ding Junqiang , Zheng Hongjian , Mu Chunhua , Wu Jianyu , Mahuku George 
Published: October 2016

AbstractFusarium ear rot (FER) incited by Fusarium verticillioides is a major disease of maize that reduces grain quality globally. Host resistance is the most suitable strategy for managing the disease. We report the results of genome-wide association study (GWAS) to detect alleles associated with increased resistance to FER in a set of 818 tropical maize inbred lines evaluated in three environments. Association tests performed using 43,424 single-nucleotide polymorphic (SNPs) markers identified 45 SNPs and 15 haplotypes that were significantly associated with FER resistance. Each associated SNP locus had relatively small additive effects on disease resistance and accounted for 1–4% of trait variation. These SNPs and haplotypes were located within or adjacent to 38 candidate genes, 21 of which were candidate genes associated with plant tolerance to stresses, including disease resistance. Linkage mapping in four biparental populations to validate GWAS results identified 15 quantitative trait loci (QTL) associated with F. verticillioides resistance. Integration of GWAS and QTL to the maize physical map showed eight colocated loci on chromosomes 2, 3, 4, 5, 9, and 10. QTL on chromosomes 2 and 9 are new. These results reveal that FER resistance is a complex trait that is conditioned by multiple genes with minor effects. The value of selection on identified markers for improving FER resistance is limited; rather, selection to combine small effect resistance alleles combined with genomic selection for polygenic background for both the target and general adaptation traits might be fruitful for increasing FER resistance in maize.
Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers
Authors: Morgan Andrew P , Didion John P , Doran Anthony G , Holt James M , McMillan Leonard , Keane Thomas M , de Villena Fernando Pardo-Manuel 
Published: October 2016

Abstract
Wild-derived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. Here, we report the whole-genome sequencing of two wild-derived mouse inbred strains, LEWES/EiJ and ZALENDE/EiJ, of Mus musculus domesticus origin. These two inbred strains were selected based on their geographic origin, karyotype, and use in ongoing research. We generated 14× and 18× coverage sequence, respectively, and discovered over 1.1 million novel variants, most of which are private to one of these strains. This report expands the number of wild-derived inbred genomes in the Mus genus from six to eight. The sequence variation can be accessed via an online query tool; variant calls (VCF format) and alignments (BAM format) are available for download from a dedicated ftp site. Finally, the sequencing data have also been stored in a lossless, compressed, and indexed format using the multi-string Burrows-Wheeler transform. All data can be used without restriction.
A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity inDrosophilaWings
Authors: Carvajal-Gonzalez Jose Maria , Mulero-Navarro Sonia , Smith Michael , Mlodzik Marek 
Published: October 2016

AbstractMost mutant alleles in the Fz-PCP pathway genes were discovered in classic Drosophila screens looking for recessive loss-of-function (LOF) mutations. Nonetheless, although Fz-PCP signaling is sensitive to increased doses of PCP gene products, not many screens have been performed in the wing under genetically engineered Fz overexpression conditions, mostly because the Fz phenotypes were strong and/or not easy to score and quantify. Here, we present a screen based on an unexpected mild Frizzled gain-of-function (GOF) phenotype. The leakiness of a chimeric Frizzled protein designed to be accumulated in the endoplasmic reticulum (ER) generated a reproducible Frizzled GOF phenotype in Drosophila wings. Using this genotype, we first screened a genome-wide collection of large deficiencies and found 16 strongly interacting genomic regions. Next, we narrowed down seven of those regions to finally test 116 candidate genes. We were, thus, able to identify eight new loci with a potential function in the PCP context. We further analyzed and confirmed krasavietz and its interactor short-stop as new genes acting during planar cell polarity establishment with a function related to actin and microtubule dynamics.
cdc-25.4, aCaenorhabditis elegansOrtholog ofcdc25, Is Required for Male Mating Behavior
Authors: Oh Sangmi , Kawasaki Ichiro , Park Jae-Hyung , Shim Yhong-Hee 
Published: October 2016

AbstractCell division cycle 25 (cdc25) is an evolutionarily conserved phosphatase that promotes cell cycle progression. Among the four cdc25 orthologs in Caenorhabditis elegans, we found that cdc-25.4 mutant males failed to produce outcrossed progeny. This was not caused by defects in sperm development, but by defects in male mating behavior. The cdc-25.4 mutant males showed various defects during male mating, including contact response, backing, turning, and vulva location. Aberrant turning behavior was the most prominent defect in the cdc-25.4 mutant males. We also found that cdc-25.4 is expressed in many neuronal cells throughout development. The turning defect in cdc-25.4 mutant males was recovered by cdc-25.4 transgenic expression in neuronal cells, suggesting that cdc-25.4 functions in neurons for male mating. However, the neuronal morphology of cdc-25.4 mutant males appeared to be normal, as examined with several neuronal markers. Also, RNAi depletion of wee-1.3, a C. elegans ortholog of Wee1/Myt1 kinase, failed to suppress the mating defects of cdc-25.4 mutant males. These findings suggest that, for successful male mating, cdc-25.4 does not target cell cycles that are required for neuronal differentiation and development. Rather, cdc-25.4 likely regulates noncanonical substrates in neuronal cells.
Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila
Authors: Katzenberger Rebeccah J , Ganetzky Barry , Wassarman David A 
Published: October 2016

Abstract
Outcomes of traumatic brain injury (TBI) vary because of differences in primary and secondary injuries. Primary injuries occur at the time of a traumatic event, whereas secondary injuries occur later as a result of cellular and molecular events activated in the brain and other tissues by primary injuries. We used a Drosophila melanogaster TBI model to investigate secondary injuries that cause acute mortality. By analyzing mortality percentage within 24 hr of primary injuries, we previously found that age at the time of primary injuries and diet afterward affect the severity of secondary injuries. Here, we show that secondary injuries peaked in activity 1–8 hr after primary injuries. Additionally, we demonstrate that age and diet activated distinct secondary injuries in a genotype-specific manner, and that concurrent activation of age- and diet-regulated secondary injuries synergistically increased mortality. To identify genes involved in secondary injuries that cause mortality, we compared genome-wide mRNA expression profiles of uninjured and injured flies under age and diet conditions that had different mortalities. During the peak period of secondary injuries, innate immune response genes were the predominant class of genes that changed expression. Furthermore, age and diet affected the magnitude of the change in expression of some innate immune response genes, suggesting roles for these genes in inhibiting secondary injuries that cause mortality. Our results indicate that the complexity of TBI outcomes is due in part to distinct, genetically controlled, age- and diet-regulated mechanisms that promote secondary injuries and that involve a subset of innate immune response genes.
A Low Background Gamma Ray Spectrometer with Anticosmic Shielding
Authors: Hung Nguyen Quoc , Hai Vo Hong , Tuyet Tran Kim , Tuan Ho Lai 
Published: October 2016

The article describes a gamma ray spectrometer protected by a lead shield (Model 747E Canberra lead shield) and an active shield made of an 80~cm \(\times\) 80~cm \(\times\) 3~cm plastic scintillator plate in anticoincidence on top of the lead shield. The detector used as low background gamma-spectrometer is a high purity Germanium crystal of model GC2018 Canberra. The background count rate currently achieved (30-2400 keV) is 1.27 cps without anticoincidence. The level of background suppression obtained from the active protection is 0.80 overall and about 0.43 for the 511 keV gamma line. The gamma ray spectrometer is installed and operated in the Nuclear	Laboratory, Department of Nuclear Physics, University of Science,	HCMC-Vietnam National University.
Measuring anti-bunching Effect from Single Dye Molecules and Single Quantum Dots
Authors: Bao Nguyen Thi Thanh , Trung Dinh Van , Phuong Dang Tuyet 
Published: October 2016

Antibunching is a quantum effect demonstrating clearly the quantum	nature of the radiation field. Its detection through measurements of the	second order correlation function is a direct proof of the presence of	single molecule or single nano particle. In this paper we present the	experimental setup of the Hanbury Brown - Twiss interferometer and the	measurement results of the antibunching effect from single Rhodamine B dye	molecules and single CdTe quantum dots in dilute solution. By fitting the	second order correlation data, we derive a fluorescence lifetime of	approximately 2 ns for Rhodamine B and 45 ns for CdTe quantum dots. Our	results demonstrate an alternative way for determining the fluorescence	lifetime using the antibunching effect.
Technology Update: Flexible, Single-Skin Completion Concept Meets Well Integrity, Zonal Isolation Needs
Authors: Sidle Brian 
Published: October 2016

Technology Update
As deeper and more complex well designs proliferate throughout oil and gas fields, well completion methods are challenged and new technologies are emerging to ensure safe, cost-efficient, and optimized completions.
The Welltec Flex-Well completion concept is a flexible, single-skin (monobore) system that allows fit-for-purpose completion designs that can be as minimal or intricate as needed for optimal reservoir drainage and do not require the use of cement or swellable packers (Fig. 1).
Reliable and effective annular barriers continue to be crucial to well management for safety and performance. Cementing has been the industry’s conventional means of creating these barriers, having been used for almost 100 years (American Oil & Gas Historical Society 2015). However, the industry is not drilling and completing wells the way that it did a century ago.
The advances in drilling, particularly those related to horizontal well technology, have led to well designs and completion environments that often exceed the capabilities of cement to provide a reliable annular barrier that will last as long as the well. Efforts to overcome the challenges of many of today’s wells with cement can lead to complicated, expensive, and time-consuming operations.
The use of certain swellable packers has arisen as an accepted alternative, primarily because of time savings. However, their degradable polymer content has a significant risk of failure in harsh downhole well environments. Wells with swellables have been shown to leak approximately 50% of the time after 5 years from the time of installation (Plessing and Arnskov 2011).
With more than half of the world’s rigs drilling highly deviated or horizontal wells, and an increasing number of mature fields with depleted well zones, the challenges of such wells call for barriers that not only are cost-efficient but will also remain effective throughout the well’s lifetime.
Expandable Annular Barrier
A key component of the flexible, singleskin completion system is the Welltec Annular Barrier (Fig. 2), an all-metal expandable barrier with a large expansion ratio that was developed for a wide variety of applications in well construction, including well integrity and zonal isolation. Designed for the specific well during its construction phase, before the well is spudded, the barrier delivers reliable annular isolation and maximizes the ability to handle pressure change across the entire borehole, without internal restrictions, over the life of the well.