bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiotensin‐Converting Enzyme Inhibitor Initiation and Dose Uptitration in Children With Cardiovascular Disease: A Retrospective Review of Standard Clinical Practice and a Prospective Randomized Clinical Trial
Authors: Roche S. Lucy , Timberlake Kathryn , Manlhiot Cedric , Balasingam Mervin , Wilson Judith , George Kristen , McCrindle Brian W. , Kantor Paul F. 
Published: May 2016

Background

Angiotensin‐converting enzyme inhibitors (
ACEI
s) are a mainstay of medical management in pediatric cardiology. However, there are no data defining how best to initiate and uptitrate the dose of these medications in children.

Methods and Results

Retrospective chart review revealed only 24% of our pediatric cardiology inpatients were discharged on predefined optimal doses of
ACEI
s and few underwent further dose uptitration in the 8 weeks after hospital discharge. Therefore, 2 alternative protocols for initiation of captopril were compared in a prospective randomized clinical trial. A “rapid uptitration” protocol reached an optimal dose on day 3, whereas the alternative, “prolonged uptitration” protocol, reached an optimal dose on day 9. Forty‐6 patients (54% male) were recruited to the trial, with a median age of 0.7 year (
IQR
0.5–2.3 years). Captopril was initiated while in intensive care in 39% of patients and on the cardiology ward in 61%. There were no differences between the protocols in episodes of hypotension, symptomatic hypotension, or indices of renal function. Patients following the rapid protocol reached higher doses of captopril (0.93±0.24 versus 0.57±0.38 mg/kg per dose,
P
<0.0001) and were more likely to have achieved the predefined target (88% versus 43%,
P
=0.002) and optimal
ACEI
doses (80% versus 29%,
P
=0.001) before discharge.

Conclusions

A protocol of rapid
ACEI
dose uptitration for infants and children with cardiovascular disease can be introduced safely, even in patients receiving intensive care therapy. Compared with standard clinical practice or with a more prolonged protocol, rapid
ACEI
dose uptitration achieves a higher dosage in this population with no evident disadvantages.

Clinical Trial Registration

URL
:
https://www.clinicaltrials.gov/
. Unique identifier:
NCT
00742040.
Impact of a Rural Regional Myocardial Infarction System of Care in Wyoming
Authors: Langabeer James R. , Smith Derek T. , Cardenas‐Turanzas Marylou , Leonard Benjamin L. , Segrest Wendy , Krell Chris , Owan Theophilus , Eisenhauer Michael D. , Gerard Daniela 
Published: May 2016

Background
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for patients presenting with ST‐segment elevation myocardial infarction; however, to be effective, PCI must be performed in a timely manner. Rural regions are at a severe disadvantage, given the relatively sparse number of PCI hospitals and long transport times.

Methods and Results

We developed a standardized treatment and transfer protocol for ST‐segment elevation myocardial infarction in the rural state of Wyoming. The study design compared the time‐to‐treatment outcomes during the pre‐ and postintervention periods. Details of the program, changes in reperfusion strategies over time, and outcome improvements in treatment times were reported. From January 1, 2013, to December 31, 2014, 889 patients were treated in 11 PCI‐capable hospitals (4 in Wyoming, 7 in adjoining states). Given the large geographic distance in the state (median of 47 miles between patient and PCI center), 52% of all patients were transfers, and 36% were administered fibrinolysis at the referral facility. Following the intervention, there was a significant shift toward greater use of primary PCI as the dominant reperfusion strategy (from 47% to 60%,
P
=0.002), and the median total ischemic time from symptom onset to arterial reperfusion was decreased by 92 minutes (
P
<0.001). There was a similar significant reduction in median time from receiving center door to balloon of 11 minutes less than the baseline time (
P
<0.01).

Conclusions
Rural systems of care for ST‐segment elevation myocardial infarction require increased levels of cooperation between emergency medical services agencies and hospitals. This study confirms that total ischemic times can be reduced through a coordinated rural statewide initiative.
Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor
Authors: Shahrin Nur Hezrin , Diakiw Sonya , Dent Lindsay A. , Brown Anna L. , D’Andrea Richard J. 
Published: May 2016

Key Points
Klf5 functions in hematopoiesis to regulate HSC and progenitor proliferation and localization in the bone marrow. Klf5 is required in the granulocyte lineage and positively affects neutrophil output at the expense of eosinophil production.
CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date
Authors: Park Jae H. , Geyer Mark B. , Brentjens Renier J. 
Published: May 2016

Abstract
Adoptive transfer of T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 has produced impressive results in treating patients with B-cell malignancies. Although these CAR-modified T cells target the same antigen, the designs of CARs vary as well as several key aspects of the clinical trials in which these CARs have been studied. It is unclear whether these differences have any impact on clinical outcome and treatment-related toxicities. Herein, we review clinical results reflecting the investigational use of CD19-targeted CAR T-cell therapeutics in patients with B-cell hematologic malignancies, in light of differences in CAR design and production, and outline the limitations inherent in comparing outcomes between studies.
Treosulfan-based conditioning for allogeneic HSCT in children with chronic granulomatous disease: a multicenter experience
Authors: Morillo-Gutierrez Beatriz , Beier Rita , Rao Kanchan , Burroughs Lauri , Schulz Ansgar , Ewins Anna-Maria , Gibson Brenda , Sedlacek Petr , Krol Ladislav , Strahm Brigitte , Zaidman Irina , Kalwak Krzysztof , Talano Julie-An , Woolfrey Ann , Fraser Chris , Meyts Isabelle , Müller Ingo , Wachowiak Jacek , Bernardo Maria Ester , Veys Paul , Sykora Karl-Walter , Gennery Andrew R. , Slatter Mary 
Published: May 2016

Key Points
Treosulfan, a low-toxicity alkylating agent, can be used effectively as part of conditioning for HSCT in children with CGD. Long-term follow-up is required to ascertain effects, particularly on gonadal function and compare with other regimens.
Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty
Authors: Lippincott Margaret F. , Chan Yee-Ming , Delaney Angela , Rivera-Morales Dianali , Butler James P. , Seminara Stephanie B. 
Published: May 2016

Context:
Some patients with idiopathic hypogonadotropic hypogonadism (IHH) undergo spontaneous activation of their hypothalamic-pituitary-gonadal axis resulting in normalization of steroidogenesis and/or gametogenesis, a phenomenon termed reversal.

Objective:
To assess the responsiveness of the GnRH neuronal network to exogenous kisspeptin administration in IHH patients who have undergone reversal.

Participants:
Six men with congenital IHH and evidence for reversal.

Intervention:
Subjects underwent q10 min blood sampling to measure GnRH-induced LH secretion at baseline and in response to iv boluses of kisspeptin (0.24–2.4 nmol/kg) and GnRH (75 ng/kg).

Results:
Individuals with sustained reversal of their hypogonadotropism (spontaneous LH pulses) responded to exogenous kisspeptin with a GnRH-induced LH pulse. Individuals who had reversal but then subsequently suffered relapse of their IHH (loss of spontaneous LH pulsatility) did not respond to kisspeptin.

Conclusions:
The ability of kisspeptin to stimulate a GnRH-induced LH pulse correlates with the presence of endogenous LH pulses. These data suggest that reversal of hypogonadotropism, and by extension sexual maturation, may be due to the acquisition of kisspeptin responsiveness.
Drosophila Ana1 is required for centrosome assembly and centriole elongation
Authors: Saurya Saroj , Roque Hélio , Novak Zsofia A. , Wainman Alan , Aydogan Mustafa G. , Volanakis Adam , Sieber Boris , Pinto David Miguel Susano , Raff Jordan W. 
Published: May 2016

ABSTRACT
Centrioles organise centrosomes and cilia, and these organelles have an important role in many cell processes. In flies, the centriole protein Ana1 is required for the assembly of functional centrosomes and cilia. It has recently been shown that Cep135 (also known as Bld10) initially recruits Ana1 to newly formed centrioles, and that Ana1 then recruits Asl (known as Cep152 in mammals) to promote the conversion of these centrioles into centrosomes. Here, we show that ana1 mutants lack detectable centrosomes in vivo, that Ana1 is irreversibly incorporated into centrioles during their assembly and appears to play a more important role in maintaining Asl at centrioles than in initially recruiting Asl to centrioles. Unexpectedly, we also find that Ana1 promotes centriole elongation in a dose-dependent manner: centrioles are shorter when Ana1 dosage is reduced and are longer when Ana1 is overexpressed. This latter function of Ana1 appears to be distinct from its role in centrosome and cilium function, as a GFP–Ana1 fusion lacking the N-terminal 639 amino acids of the protein can support centrosome assembly and cilium function but cannot promote centriole over-elongation when overexpressed.
O Olho Humano e os Mecanismos da Visão como Objeto de Ensino: Reflexões Sobre um Processo Colaborativo
Authors: De Bodas Flávia Renata Lemes , Viana Karine Bezerra , Errobidart Nádia Cristina Guimarães , Jardim Maria Inês de Affonseca , Da Silva Edy Wilson Ferreira Mendes 
Published: May 2016

<p>Este relato apresenta as reflexões iniciais sobre as ações de um grupo colaborativo quanto ao planejamento e execução de uma sequência<br />didática desenvolvida em seis turmas de segundo ano do Ensino Médio de uma escola estadual do município de Campo Grande, Mato Grosso do Sul. Especificamente relatamos o trabalho colaborativo, desenvolvido por membros do grupo, de planejamento e aplicação de uma atividade composta de aula expositiva usando ferramenta tecnológica e uma atividade experimental demonstrativa sobre o processo de formação de imagens no olho humano e alguns defeitos de visão. O objetivo é evidenciar a importância atribuída pelos acadêmicos ao processo colaborativo desenvolvido na atividade. O tema da atividade sobre o olho humano foi selecionado após uma discussão, entre professores de Ensino Médio de escolas públicas de Campo Grande – MS, docentes da formação inicial do curso de Licenciatura em Física da UFMS e acadêmicos do curso. Os resultados sugerem que os primeiros passos em busca de um trabalho realmente colaborativo e que contribua para a formação reflexivacrítica dos futuros professores de Física estão no caminho certo. Os acadêmicos pontuam em seus diários de bordo que as discussões com os<br />professores regentes e demais membros do grupo auxiliaram na identificação de possíveis problemas vivenciados em sala de aula e propiciaram a reflexão sobre possíveis soluções.</p>
Seleção de cultivares de cana-de-açúcar para a Zona da Mata Norte de Pernambuco I: Início de safra
Authors: Albuquerque A. P. C. , Bastos G. Q. , Dutra Filho J. A. , Souto L. S. , Maracajá P. B. , Simões Neto D. E. 
Published: May 2016

<p>Sendo os cultivares melhorados a base de sustentação e desenvolvimento do setor sucroeneregético no Brasil, objetivou-se com este trabalho avaliar o desempenho agroindustrial de 26 cultivares de cana-de-açúcar na microrregião canavieira da Mata Norte de Pernambuco. O experimento foi conduzido na área agrícola da Usina Olho D’água, onde foi utilizado o delineamento experimental em blocos casualizados com quatro repetições. As variáveis analisadas foram: toneladas de pol por hectare, toneladas de cana por hectare, fibra, pol % corrigida, pureza, teor de sólidos solúveis e açúcar total recuperável. Realizou-se a análise de variância conjunta dos experimentos e estimativa de parâmetros genéticos, as médias foram agrupadas pelo teste de Scott e Knott ao nível de 5% de probabilidade. Realizou-se ainda a rentabilidade econômica bruta de cada cultivar. Constatou-se que a seleção de cultivares superiores deve ser baseada nas variáveis TPH e TCH. Como opções de cultivo comercial para a primeira época de colheita destacam-se como mais produtivos, RB92579, RB867515, e RB942991.</p><p align="center"><strong><em>Selection of sugarcane cultivars to the North Forest Zone of Pernambuco I: Home crop</em></strong></p><p><strong>Abstract: </strong>Improved cultivars are support base and development of energétic and alcohol sector in Brazil, aimed with this work was to evaluate the agroindustrial performance of 26 sugarcane cultivars in the microrregion da Mata Norte of Pernambuco. The experiment was conducted in the agricultural area of the sugarmill Olho d'gua, which was used a randomized block with four replications. The variables analyzed were tons of pol per hectare, sugarcane tons per hectare, fiber, corrected pol%, purity, soluble solids content and total recoverable sugar. Were conducted the variance analysis and estimation of genetic parameters, the averages were grouped by the Scott and Knott test at 5% probability. It was held still gross economic profitability of each cultivar. The selection of superior cultivars should be based on TPH and TCH variables. As commercial cultivation options for the first harvest season stand out as more productive, RB92579, RB867515 and RB942991.<strong> </strong></p>
ASPCAP: THE APOGEE STELLAR PARAMETER AND CHEMICAL ABUNDANCES PIPELINE
Authors: García Pérez Ana E. , Prieto Carlos Allende , Holtzman Jon A. , Shetrone Matthew , Mészáros Szabolcs , Bizyaev Dmitry , Carrera Ricardo , Cunha Katia , García-Hernández D. A. , Johnson Jennifer A. , Majewski Steven R. , Nidever David L. , Schiavon Ricardo P. , Shane Neville , Smith Verne V. , Sobeck Jennifer , Troup Nicholas , Zamora Olga , Weinberg David H. , Bovy Jo , Eisenstein Daniel J. , Feuillet Diane , Frinchaboy Peter M. , Hayden Michael R. , Hearty Fred R. , Nguyen Duy C. , O’Connell Robert W. , Pinsonneault Marc H. , Wilson John C. , Zasowski Gail 
Published: May 2016

ABSTRACT
The Apache Point Observatory Galactic Evolution Experiment (APOGEE) has built the largest moderately high-resolution (R ≈ 22,500) spectroscopic map of the stars across the Milky Way, and including dust-obscured areas. The APOGEE Stellar Parameter and Chemical Abundances Pipeline (ASPCAP) is the software developed for the automated analysis of these spectra. ASPCAP determines atmospheric parameters and chemical abundances from observed spectra by comparing observed spectra to libraries of theoretical spectra, using χ
2 minimization in a multidimensional parameter space. The package consists of a fortran90 code that does the actual minimization and a wrapper IDL code for book-keeping and data handling. This paper explains in detail the ASPCAP components and functionality, and presents results from a number of tests designed to check its performance. ASPCAP provides stellar effective temperatures, surface gravities, and metallicities precise to 2%, 0.1 dex, and 0.05 dex, respectively, for most APOGEE stars, which are predominantly giants. It also provides abundances for up to 15 chemical elements with various levels of precision, typically under 0.1 dex. The final data release (DR12) of the Sloan Digital Sky Survey III contains an APOGEE database of more than 150,000 stars. ASPCAP development continues in the SDSS-IV APOGEE-2 survey.
FORMATION OF GLOBULAR CLUSTERS IN ATOMIC-COOLING HALOS VIA RAPID GAS CONDENSATION AND FRAGMENTATION DURING THE EPOCH OF REIONIZATION
Authors: Kimm Taysun , Cen Renyue , Rosdahl Joakim , Yi Sukyoung K. 
Published: May 2016

ABSTRACT
We investigate the formation of metal-poor globular clusters (GCs) at the center of two dark matter halos with

at

using cosmological radiation-hydrodynamics simulations. We find that very compact (≲1 pc) and massive (

) clusters form rapidly when pristine gas collapses isothermally with the aid of efficient Lyα emission during the transition from molecular-cooling halos to atomic-cooling halos. Because the local free-fall time of dense star-forming gas is very short (

), a large fraction of the collapsed gas is turned into stars before stellar feedback processes blow out the gas and shut down star formation. Although the early stage of star formation is limited to a small region of the central star-forming disk, we find that the disk quickly fragments due to metal enrichment from supernovae. Sub-clusters formed in the fragmented clouds eventually merge with the main cluster at the center. The simulated clusters closely resemble the local GCs in mass and size but show a metallicity spread that is much wider than found in the local GCs. We discuss a role of pre-enrichment by Pop III and II stars as a potential solution to the latter issue. Although not without shortcomings, it is encouraging that a naive blind (not tuned) cosmological simulation presents a possible channel for the formation of at least some massive GCs.
SYNCHRONIC CORONAL HOLE MAPPING USING MULTI-INSTRUMENT EUV IMAGES: DATA PREPARATION AND DETECTION METHOD
Authors: Caplan R. M. , Downs C. , Linker J. A. 
Published: May 2016

ABSTRACT
We describe a method for the automatic mapping of coronal holes (CHs) using simultaneous multi-instrument EUV imaging data. Synchronized EUV images from STEREO/EUVI A and B 195 Å and SDO/AIA 193 Å are preprocessed, including point-spread function deconvolution and the application of data-derived intensity corrections which account for center-to-limb variations (limb brightening) and inter-instrument intensity normalization. We systematically derive a robust limb-brightening correction that takes advantage of unbiased long-term averages of data and respects the physical nature of the problem. The new preprocessing greatly assists in CH detection, allowing for the use of a simplified variable-connectivity, two-threshold region-growing image segmentation algorithm to obtain consistent detection results. We generate synchronic EUV and CH maps, and show a preliminary analysis of CH evolution. Several data and code products are made available to the community (www.predsci.com/chd): for the period of this study (2010 June 10 to 2014 August 18), we provide synchronic EUV and CH map data at 6 hr cadence, data-derived limb-brightening corrections for STEREO/EUVI A and B 195 Å and SDO/AIA 193 Å, and inter-instrument correction factors to equate their intensities. We also provide the CH image segmentation code module (ezseg) implemented in both FORTRAN-OpenMP and GPU-accelerated C-CUDA. A complete implementation of our CH detection pipeline in the form of a ready-to-use MATLAB driver script euv2chm utilizing ezseg is also made available.
X-RAY PROPERTIES OF THE YOUNGEST RADIO SOURCES AND THEIR ENVIRONMENTS
Authors: Siemiginowska Aneta , Sobolewska Małgosia , Migliori Giulia , Guainazzi Matteo , Hardcastle Martin , Ostorero Luisa , Stawarz Łukasz 
Published: May 2016

ABSTRACT
We present the first results from our X-ray study of young radio sources classified as compact symmetric objects (CSOs). Using the Chandra X-ray Observatory we observed six CSOs for the first time in X-rays, and re-observed four CSOs already observed with XMM-Newton or BeppoSAX. We also included six other CSOs with archival data to built a pilot study of a sample of the 16 CSO sources observed in X-rays to date. All the sources are nearby,

, and the age of their radio structures (

yr) has been derived from the expansion velocity of their hot spots. Our results show the heterogeneous nature of the CSOs’ X-ray emission, indicating a complex environment associated with young radio sources. The sample covers a range in X-ray luminosity,

–1045 erg s−1, and intrinsic absorbing column density of

–1022 cm−2. In particular, we detected extended X-ray emission in 1718−649; a hard photon index of

in 2021+614 and 1511+0518 consistent with either a Compton-thick absorber or non-thermal emission from compact radio lobes, and in 0710+439 an ionized iron emission line at

keV and EW

–1.4 keV, and a decrease by an order of magnitude in the 2–10 keV flux since the 2008 XMM-Newton observation in 1607+26. We conclude that our pilot study of CSOs provides a variety of exceptional diagnostics and highlights the importance of deep X-ray observations of large samples of young sources. This is necessary in order to constrain theoretical models for the earliest stage of radio source evolution and to study the interactions of young radio sources with the interstellar environment of their host galaxies.
STUDY OF A SUDDEN QPO TRANSITION EVENT IN THE BLACK HOLE SOURCE XTE J1550-564
Authors: Sriram K. , Rao A. R. , Choi C. S. 
Published: May 2016

ABSTRACT
The transition of type B/A quasi-periodic oscillations (QPOs) is often associated with a sudden flux change at the peak of the outburst in black hole X-ray binaries. Recent studies show that these variations are connected to the jet ejection phenomenon in the inner regions of the accretion disk. One such event of the black hole source XTE J1550-564 is investigated, where a type A QPO transforms to type B in the first transition. In the second transition, a notable increase in the flux was observed in the 13–60 keV band. The dynamical energy-dependent power density spectrum and broadband energy spectrum obtained using the Rossi X-ray Timing Explorer data of this event were inspected to understand the energetics of the inner accretion disk. During these transitions, both disk and corona parameters were found to be varying along with their corresponding fluxes. We discuss the plasma ejection model scenario in the context of the first transition and the condensation of the corona in the inner region for the second transition event. Spectral results were used to derive the critical mass accretion rate, the amount of condensation, and the critical luminosity needed for the condensation process. We found the results to be in well agreement with theoretical simulations.