bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Electrodermal Activity and Cardiac Troponin in Patients with Paroxysmal Sympathetic Hyperactivity
Authors: Beers Louis , Bouvain Jana , Reinsberger Claus , Jakobsmeyer Rasmus , Sarkis Rani , Lee Jong Woo 
Published: September 2024

AbstractObjectiveTo determine the relationship between electrodermal activity (EDA) and cardiac troponin in patients with paroxysmal sympathetic hyperactivity (PSH).MethodsThis was a study with prospectively-identified patients and a retrospective analysis utilizing electrodermal data taken from the wrist-worn Empatica E4 device (Empatica Srl, Milan, Italy) and troponin values obtained from critically-ill patients with suspected PSH (N=10). The maximum EDA value and temporally-nearest cardiac troponin were correlated to test for significance using Pearson correlation coefficient.ResultsA moderate correlation was found between EDA and troponin in 10 patients using the most temporally-proximal troponin to each patient’s maximal EDA (r=0.634; p = 0.049). A subanalysis was performed excluding any patients whose available troponin data did not fall within seven days of their maximal EDA, which demonstrated a strong correlation (r=0.943; p = 0.005). No relationships between troponin and pulse, blood pressure, or temperature were found.ConclusionsThis study establishes an association between wrist-worn EDA and a measure of possible myocardial injury in critically ill patients with PSH. Patients with elevated sympathetic activity may be at increased risk for concurrent cardiac injury or dysfunction, and thus EDA data from wrist-worn monitors may provide clinically significant data regarding sympathetic function.
The Impact of Chlorinated Drinking Water Exposure on Gut Microbiota Development in Infants: a Randomised Controlled Trial
Authors: Parkin Kimberley , Christophersen Claus T. , Verhasselt Valerie , Palmer Debra J. , Cooper Matthew N. , Prescott Susan L. , Silva Desiree , Martino David 
Published: September 2024

ABSTRACTBackgroundEarly gut microbiota disruptions can increase the risk for dysbiosis and predispose to chronic diseases. While chlorinated drinking water is generally considered safe, the antimicrobial effects of chlorine-based disinfectants may negatively impact the developing infant microbiota, which is particularly vulnerable during this critical period. This study investigates the specific effects of chlorinated water on the gut microbiome in infants.MethodsThe waTer qUality and Microbiome Study (TUMS) is a double-blinded, randomized controlled trial (RCT). Six-month old infants (n=197) received either de-chlorinated drinking water (via benchtop filtration), or regular tap water for twelve months. Stool samples were collected at six-months (baseline) and at eighteen-months of age. Metagenomic sequencing was used for faecal microbiome analysis. Samples of participant tap water was also collected pre- and post-intervention.ResultsParticipants were balanced for sex, delivery method, and breast-feeding status at time of recruitment between the control (n=98) and treatment (n=99) groups. We collected a total of 170 baseline stool samples (83 in the control group and 87 in the treatment group), and 130 follow-up stool samples (65 in the control group and 65 in the treatment group). Interindividual variation was higher at six-months compared to eighteen months. No significant differences in overall community structure (beta diversity (p=0.35), richness (p=0.98) or Shannon Index (p=0.45)) were found between treatment groups. However, 55 genera were differentially abundant at follow-up (adjusted p-value < 0.01), primarily within the Firmicutes phylum. Analysis of metabolic pathways revealed the chlorinated water group showed significantly higher abundance of antibiotic resistance genes mostly attributable toEscherichiaandKlebsiellaspecies.ConclusionWater chlorination induces predominantly minor changes in infant gut microbiome composition; but appears to increase the abundance of antibiotic-resistant genes. While water chlorination remains a vital public health tool for ensuring safe drinking water, our findings underscore the need for continued research into the potential for increased antibiotic resistance and suggest there may be value in exploring alternative disinfectant strategies.
PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration
Authors: Deng Yu , Banerjee Tatsat , Pal Dhiman Sankar , Banerjee Parijat , Zhan Huiwang , Borleis Jane , Igleias Pablo A. , Devreotes Peter N. 
Published: September 2024

AbstractSymmetry breaking, polarity establishment, and spontaneous cell protrusion formation are fundamental but poorly explained cell behaviors. Here, we demonstrate that a biochemical network, where the mutually inhibitory localization of PIP5K and Ras activities plays a central role, governs these processes. First, in resting cells devoid of cytoskeletal activity, PIP5K is uniformly elevated on the plasma membrane, while Ras activity remains minimal. Symmetry is broken by spontaneous local displacements of PIP5K, coupled with simultaneous activations of Ras and downstream signaling events, including PI3K activation. Second, knockout of PIP5K dramatically increases both the incidence and size of Ras-PI3K activation patches, accompanied by branched F-actin assembly. This leads to enhanced cortical wave formation, increased protrusive activity, and a shift in migration mode. Third, high inducible overexpression of PIP5K virtually eliminates Ras-PI3K signaling, cytoskeletal activity, and cell migration, while acute recruitment of cytosolic PIP5K to the membrane induces contraction and blebs in cancer cells. These arrested phenotypes are reversed by reducing myosin II activity, indicating myosin’s involvement in the PIP5K-Ras-centered regulatory network. Remarkably, low inducible overexpression of PIP5K unexpectedly facilitates polarity establishment, highlighting PIP5K as a highly sensitive master regulator of these processes. Simulations of a computational model combining an excitable system, cytoskeletal loops, and dynamic partitioning of PIP5K recreates the experimental observations. Taken together, our results reveal that a bistable, mutually exclusive localization of PIP5K and active Ras on the plasma membrane triggers the initial symmetry breaking. Coupled actomyosin reduction and increased actin polymerization lead to intermittently extended protrusions and, with feedback from the cytoskeleton, self-organizing, complementary gradients of PIP5K versus Ras steepen, raising the threshold of the networks at the rear and lowering it at the front to generate polarity for cell migration.
Analysis of barriers to Maintenance 4.0 in manufacturing industries
Authors: Naik Mahadev Laxman , Kirkire Milind Shrikant 
Published: September 2024

PurposeAsset maintenance in manufacturing industries is a critical issue as organizations are highly sensitive towards maximizing asset uptime. In the advent of Industry 4.0, maintenance is increasingly becoming technology driven and is being termed as Maintenance 4.0. Several barriers impede the implementation of Maintenance 4.0. This article aims at - exploring the barriers to implementation of Maintenance 4.0 in manufacturing industries, categorizing them, analysing them to prioritize and suggesting the digital technologies to overcome them.Design/methodology/approachTwenty barriers to the implementation of Maintenance 4.0 were identified through literature survey and discussion with the industry experts. The identified barriers were divided into five categories based on their source of occurrence and prioritized using fuzzy-technique for order preference by similarity to ideal solution (TOPSIS), sensitivity analysis was carried out to check the robustness of the solution.Findings“Data security issues” has been ranked as the most influencing barrier towards the implementation of Maintenance 4.0, whereas “lack of skilled engineers and data scientists” is the least influencing barrier that impacts the implementation of Maintenance 4.0 in the manufacwturing industries.Practical implicationsThe outcomes of this research will help manufacturing industries, maintenance engineers/managers, policymakers, and industry professionals for detailed understanding of barriers and identify easy pickings while implementing Maintenance 4.0.Originality/valueManufacturing industries are witnessing a paradigm shift due to digitization and maintenance 4.0 forms the cornerstone. Little research has been carried in Maintenance 4.0 and its implementation; this article will help in bridging the gap. The prioritization of the barriers and digital course of actions to overcome those is a unique contribution of this article.
2024 practice analysis: a comparison of expectations vs actual performance of essential competencies in public relations
Authors: Neill Marlene S. , Combs Lauren , Roker Raphael , Drewry Emeri , Hood Lia , Vaughan Mallory , Binford Aliyah , Joyce McKenna 
Published: September 2024

PurposeWe conducted the Universal Accreditation Board (UAB) practice analysis to examine perceptions of US public relations practitioners and educators regarding the essential competencies for entry-level and mid-career professionals. This is a trend analysis survey that is conducted every five years to assess changes in required competencies.Design/methodology/approachThe survey was distributed via email to organizations affiliated with the UAB. Two variations of the survey were available to differentiate between practitioners and educators. The study was conducted from February through March of 2024.FindingsWe found practitioners’ expectations for others exceeded their own actual performance levels. This may be attributed to social comparison bias. We have provided recommendations for updating the Accreditation in Public Relations (APR) and certificate exams based on our findings. For example, we recommend senior professionals adopt a nurturing leadership style when mentoring young professionals. The study also revealed that educators overestimated generative artificial intelligence (AI) use in the workplace, as practitioners exhibited a slower rate of adoption of AI. The literature and theories that guided the paper were AI use, the history of accreditation in public relations and the diffusion of innovation theory.Originality/valueThis research paper provides insights related to the diffusion of AI competencies in the workplace. Additionally, this research adds to public relations literature by revealing the gap in expectations of senior professionals for beginning and mid-career professionals and their own job performance.
Transforming luxury: young consumers' motivations towards purchasing virtual luxury non-fungible token wearables
Authors: Lee Hanna , Rana Md. Rafiqul Islam , Xu Yingjiao 
Published: September 2024

PurposeThis study explores young consumers' motivations for purchasing Virtual Luxury Non-Fungible Token Wearables (VL-NFTs) from luxury brands, which are virtually crafted luxury wearables minted as blockchain-based NFTs. Specifically, it investigates the relationships among consumers' perceived value of VL-NFTs, engagement with NFTs and purchase intention and the mediating effect of consumer engagement with NFTs.Design/methodology/approachData were collected via an online survey of 504 young US consumers who had previously considered purchasing luxury fashion products and NFTs. Structural equation modelling was adopted for analysis.FindingsPerceived economic, functional (uniqueness) and experiential (self-directed pleasure and affiliation) values of VL-NFTs directly influenced consumers' purchase intention. While symbolic value (self-presentation and conspicuousness) did not significantly influence purchase intention, it facilitated consumer engagement with NFTs. Moreover, consumer engagement mediated the relationship between economic and functional values and purchase intention.Research limitations/implicationsThe sample was only comprised of young consumers, limiting the generalizability. Additionally, consumers may perceive VL-NFTs differently because of differences in past experiences and the varying VL-NFT types, necessitating further investigation on consumers' motivations across different types of VL-NFTs.Originality/valueThis study contributes to the existing literature by examining the importance of multifaceted perceived-value dimensions and engagement with NFTs in consumers' motivation for purchasing VL-NFTs through the lens of the customer value framework.
The role of the socio-professional characteristics of university professors in the implementation of sustainability
Authors: González Laskibar Xabier , Insunza Aranceta Gaizka , Alvarez-Meaza Izaskun 
Published: September 2024

Purpose
In a context of growing concern about the environmental and social crisis, education for sustainability has emerged as a key educational approach to address these challenges. University education plays a crucial role in training professionals who are aware of and committed to sustainability. This study aims to examine the impact of the socio-professional characteristics of university professors on the awareness and implementation of sustainability in teaching and research.

Design/methodology/approach
This study uses the academics’ statements through a survey to describe the degree of awareness and implementation of sustainability at the University of the Basque Country (UPV/EHU) and evaluates the influence that certain socio-professional variables can have on their commitment to sustainability. For this purpose, the paper proposes the use of descriptive and inferential statistical techniques.

Findings
The research reveals that UPV/EHU is in the first phases of implementation of sustainability, indicating a low overall implementation. Therefore, it is proposed to promote internal awareness about sustainability, promote teacher training, integrate sustainability competencies in academic programs and promote research in areas with less scientific production related to sustainability, with emphasis on interdisciplinary collaboration and gender equality to achieve greater integration of sustainability in the university. In the case of the UPV/EHU, the sustainable development champions fulfill the profile of a female professor, with full-time dedication and whose disciplinary area is a minority.

Research limitations/implications
This research has an individual framework and a static nature, and the results should be interpreted only in their context. Future research should have a national framework, a longitudinal nature and a broader range of university institutional agents. Another limitation of this methodology is the question coding process (Likert scales), which opens a wide range of subjectivity for the researcher.

Originality/value
To the best of the authors’ knowledge, this is the first study that measures the degree of implementation of sustainability at the UPV/EHU with the aim of specifying its efforts in the implementation and promotion of sustainability.
Students’ performance and faculty efficiency. Assessing the role of gender through a metafrontier
Authors: Barra Cristian , Destefanis Sergio , Sena Vania , Zotti Roberto 
Published: September 2024

PurposeThis paper provides novel evidence on the role of gender in the performance of university students, which is particularly relevant to the debate on the performance of female students in science, technology, engineering and mathematics (STEM) subjects.Design/methodology/approachOur approach relies on the metafrontier approach proposed by Huang et al. (2014), which measures students' efficiency within a given faculty and the impact of the faculty’s technology on students’ efficiency. We use a sample of 53,159 first-year students in 8 faculties from a large university in southern Italy from 2002–2003 to 2010–2011.FindingsStudents’ efficiency is relatively low, reflecting an essential role of unobserved heterogeneity. The different technologies of somewhat similar faculties have minimal impact on efficiency. There is a performance gap against women in five faculties, which on average is strongest for the faculties in the pure and applied science area. This gap increases with the proportion of female students and decreases with female lecturers.Practical implicationsThe metafrontier has the benefit of providing relevant policy information on the drivers of student success by relying on data that universities routinely generate and preserve.Originality/valueThe stochastic metafrontier approach allows us to separate the group-specific frontiers from the metafrontier, yielding a decomposition of the efficiency scores of various faculties into technical efficiency scores and technological gaps.
Cite me! Perspectives on coercive citation in reviewing
Authors: Burton Suzan , Basil Debra Z. , Soboleva Alena , Nesbit Paul 
Published: September 2024

Purpose
This study builds on previous discussion of an important area for both academics and academic journals – the issue of reviewers inappropriately asking for (or “coercing”) citation of their own work. That situation creates an opportunity for (hopefully a small number of) academics to engage in unethical behaviour, often with the goal of increasing their citation count. This study aims to draw attention to this often-overlooked issue, critically considering potential reviewer motivations and offering possible remedies.

Design/methodology/approach
This study reviews literature and critically discusses this issue, offering a typology for coercive citation suggestions and sharing previously unpublished commentary from Editors of leading journals.

Findings
This study provides a typology of reviewer motivations for coercing citations, suggests potential remedies and considers the positive and negative impacts of these suggestions.

Originality/value
This study identifies an area known from multiple discussions to be important to academics and Editors, where many want changes in journals’ practices. In response, this study provides recommendations for easy changes that would decrease the opportunity for unethical behaviour by reviewers and also, for some journals, improve the quality of reviews.
Mapping global research in the field of health biotechnology for the period 1990–2023. A bibliometric analysis
Authors: De la Vega Hernández Iván Manuel , Díaz Amorin Juan , Fernández-Gomez Rodolfo 
Published: September 2024

Purpose
The purpose of this study focused on a global longitudinal bibliometric mapping of research in the field of health biotechnology between 1990 and 2023 to determine who is leading this field of knowledge and to estimate the sub-disciplines that are emerging and project those that will prevail in the future.

Design/methodology/approach
The study identified the most relevant countries, institutions and researchers, as well as the type of scientific collaborations. The applied steps applied in the study were the following: identification and selection of keyword terms by a panel of experts; design and application of an algorithm to identify these selected keywords in titles, abstracts and keywords using Web of Science terms to contrast them; performance of JCR data processing during 2023 using R, Python and VOSviewer.

Findings
Among the most relevant conclusions of the study are the following exponential growth has been observed in the study period; new branches of knowledge have emerged in which the subjects have been acquiring their own autonomous capabilities; and R&D in this field is still concentrated in a small group of core countries, and the trend is for it to remain so due to the capacity needs required.

Originality/value
This contribution seeks to systematize the existing scientific knowledge in the field of biotechnology, specifically in the area of health, using the technique of scientific mapping based on a logical model of indicators that aims to determine potential thematic ramifications.
T‐cell senescence was correlated with early atherosclerosis in patients with systemic lupus erythematosus
Authors: Pratama Mirza Zaka , Wahono Cesarius Singgih , Aslam Ahmad Bayhaqi Nasir , Chilmi Syahrul , Sari Vidia Purnama , Abdurrohman Anugrah , Sulistiyowati Ike , Aditya Aldo , Johono Maxie Felix , Robert  
Published: September 2024

AbstractAimTo investigate the correlation between T‐cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).MethodsThe study participants were 40 female SLE patients aged 18–45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima‐media thickness) and flow‐mediated dilation (FMD) and serological markers using soluble ICAM‐1 and VCAM‐1. Flow cytometry of CD4+CD57+, CD8+CD57+, CD4+CD28null, and CD8+CD28null T cells were used to assess the immunosenescence markers.ResultsThe cIMT (p < .001), sICAM‐1 (p < .001), and sVCAM‐1 (p < .001) were significantly higher in SLE patients compared with control, while FMD was significantly lower in SLE patients (p < .001). The percentages of all T‐cell senescence markers are also significantly higher in SLE patients than in healthy individuals. Positive correlations were shown between cIMT with the CD4+CD57+ (R = .301, p = .005), CD4+CD28null (R = .448, p < .001), and CD8+CD28null (R = .422, p < .001). Conversely, negative correlations were demonstrated between the FMD with CD4+CD57+ (R = −.236, p = .023), CD8+CD57+ (R = −.409, p < .001), CD4+CD28null (R = −.422, p < .001), and CD8+CD28null (R = −.318, p = .003). The soluble markers of sICAM‐1 and sVCAM‐1 were also positively correlated with the T‐cell senescence markers.ConclusionEarly sign of atherosclerosis was demonstrated in patients with SLE in this study. T‐cell senescence markers had significant correlations with the atherosclerosis markers, including the cIMT, FMD, and soluble adhesion molecules levels. Understanding the link between immunosenescence and atherosclerosis might help to identify a new method for early detection and treatment of atherosclerosis in SLE.
Nail pitting in an infant with Kawasaki disease—A novel clinical finding
Authors: Nadig Pallavi L. , Barman Prabal , Dwivedi Apoorva , Pilania Rakesh Kumar 
Published: September 2024

AbstractA variety of nail changes have been described in children with Kawasaki disease during the convalescent phase. These include Beau's lines, leukonychia, and orange‐brown chromonychia. However, nail pitting is distinctly unusual in KD. We report one such case.