bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical signs, imaging findings, and outcome in twelve cats with internal ophthalmoparesis/ophthalmoplegia
Authors: Hamzianpour Negar , Lam Richard , Tetas Roser , Beltran Elsa 
Published: December 2017

AbstractObjectiveTo retrospectively evaluate the clinical signs, imaging findings, and outcome of feline internal ophthalmoparesis/ophthalmoplegia.ProcedureMedical records were reviewed from 2008 to 2015. Inclusion criteria included cats that presented with internal ophthalmoparesis/ophthalmoplegia, underwent diagnostic imaging, and had follow‐up information available.ResultsTwelve cases of feline internal ophthalmoparesis/ophthalmoplegia were identified. Nine cats were unilaterally affected, and three cats were bilaterally affected. Affected cats had a median age of 10.54 years (range 5.75 to 13.17), and both sexes of varying breeds were affected (nine males; three females). Clinical signs including abnormal mental status (n = 9; 75%) and additional neurologic abnormalities (n = 10; 83%) were observed. Magnetic resonance imaging and/or computed tomography (MRI/CT) of the head were performed in ten cats, revealing a mass lesion in all cases with varying locations. Multicentric lymphoma was diagnosed in two cats via abdominal ultrasound and cytology. All twelve cats were euthanized due to deterioration of clinical signs and/or quality‐of‐life concerns. Median time from diagnosis to euthanasia was 3.5 days (range 0 to 80 days).ConclusionsFeline internal ophthalmoparesis/ophthalmoplegia rarely presents as the sole clinical sign in a referral hospital. Advanced imaging (MRI/CT) may be necessary to reach a definitive diagnosis in these cases. However, abdominal ultrasound would be advocated in cats with systemic clinical signs as a less expensive and less invasive diagnostic test to further investigate the possible etiology of internal ophthalmoparesis/ophthalmoplegia prior to advanced imaging. Feline cases with internal ophthalmoparesis/ophthalmoplegia associated with other intracranial signs and/or systemic clinical signs have a poor prognosis.
Quality assessment of nutrition coverage in the media: a 6-week survey of five popular UK newspapers
Authors: Kininmonth Alice R , Jamil Nafeesa , Almatrouk Nasser , Evans Charlotte E L 
Published: December 2017

ObjectivesTo investigate the quality of nutrition articles in popular national daily newspapers in the UK and to identify important predictors of article quality.SettingNewspapers are a primary source of nutrition information for the public.DesignNewspaper articles were collected on 6 days of the week (excluding Sunday) for 6 weeks in summer 2014. Predictors included food type and health outcome, size of article, whether the journalist was named and day of the week.Outcome measuresA validated quality assessment tool was used to assess each article, with a minimum possible score of −12 and a maximum score of 17. Newspapers were checked in duplicate for relevant articles. The association of each predictor on article quality score was analysed adjusting for remaining predictors. A logistic regression model was implemented with quality score as the binary outcome, categorised as poor (score less than zero) or satisfactory (score of zero or more).ResultsOver 6 weeks, 141 nutrition articles were included across the five newspapers. The median quality score was 2 (IQR −2–6), and 44 (31%) articles were poor quality. There was no substantial variation in quality of reporting between newspapers once other factors such as anonymous publishing, health outcome, aspect of diet covered and day of the week were taken into account. Particularly low-quality scores were obtained for anonymously published articles with no named journalist, articles that focused on obesity and articles that reported on high fat and processed foods.ConclusionsThe general public are regularly exposed to poor quality information in newspapers about what to eat to promote health, particularly articles reporting on obesity. Journalists, researchers, university press officers and scientific journals need to work together more closely to ensure clear, consistent nutrition messages are communicated to the public in an engaging way.
Systematic evidence review of rates and burden of harm of intravenous admixture drug preparation errors in healthcare settings
Authors: Hedlund Nancy , Beer Idal , Hoppe-Tichy Torsten , Trbovich Patricia 
Published: December 2017

ObjectiveTo examine published evidence on intravenous admixture preparation errors (IAPEs) in healthcare settings.MethodsSearches were conducted in three electronic databases (January 2005 to April 2017). Publications reporting rates of IAPEs and error types were reviewed and categorised into the following groups: component errors, dose/calculation errors, aseptic technique errors and composite errors. The methodological rigour of each study was assessed using the Hawker method.ResultsOf the 34 articles that met inclusion criteria, 28 reported the site of IAPEs: central pharmacies (n=8), nursing wards (n=14), both settings (n=4) and other sites (n=3). Using the Hawker criteria, 14% of the articles were of good quality, 74% were of fair quality and 12% were of poor quality. Error types and reported rates varied substantially, including wrong drug (~0% to 4.7%), wrong diluent solution (0% to 49.0%), wrong label (0% to 99.0%), wrong dose (0% to 32.6%), wrong concentration (0.3% to 88.6%), wrong diluent volume (0.06% to 49.0%) and inadequate aseptic technique (0% to 92.7%)%). Four studies directly compared incidence by preparation site and/or method, finding error incidence to be lower for doses prepared within a central pharmacy versus the nursing ward and lower for automated preparation versus manual preparation. Although eight studies (24%) reported ≥1 errors with the potential to cause patient harm, no study directly linked IAPE occurrences to specific adverse patient outcomes.ConclusionsThe available data suggest a need to continue to optimise the intravenous preparation process, focus on improving preparation workflow, design and implement preventive strategies, train staff on optimal admixture protocols and implement standardisation. Future research should focus on the development of consistent error subtype definitions, standardised reporting methodology and reliable, reproducible methods to track and link risk factors with the burden of harm associated with these errors.
Association of individual and neighbourhood socioeconomic status with physical activity and screen time in seventh-grade boys and girls in Berlin, Germany: a cross-sectional study
Authors: Krist Lilian , Bürger Christin , Ströbele-Benschop Nanette , Roll Stephanie , Lotz Fabian , Rieckmann Nina , Müller-Nordhorn Jacqueline , Willich Stefan N , Müller-Riemenschneider Falk 
Published: December 2017

ObjectivesFew studies have explored the impact of neighbourhood socioeconomic status (SES) on health behaviours in youths in Germany. Our aim was to investigate the association of individual and neighbourhood SES with physical activity (PA) and screen time (ST) in students aged 12–13 years in Berlin.DesignCross-sectional study.SettingSecondary schools (high schools and integrated secondary schools) in Berlin, Germany.ParticipantsA total of 2586 students aged 12–13 years (seventh grade).Main outcome measuresSociodemographics, anthropometric data and health behaviours were assessed by self-report during classes. Primary outcome was the association of individual and neighbourhood SES with meeting daily PA and exceeding daily ST recommendations. Students’ characteristics were described with means or percentages. Comparisons were performed using generalised linear mixed model yielding ORs with 95% CIs.ResultsMean (±SD) age was 12.5±0.5 years, 50.5% were girls and 34.1% had a migrant background. When adjusting for individual covariates, associations of low versus high individual SES were 0.85 (0.48; 1.52) for PA and 2.08 (1.26; 3.43) for ST. Associations of low versus high neighbourhood SES were 1.76 (1.12; 2.75) for PA and 1.54 (1.10; 2.17) for ST. After additional adjustment for school type and school neighbourhood SES, associations comparing low versus high individual and neighbourhood SES were attenuated for PA (individual SES 0.74 (0.41; 1.33) and neighbourhood SES 1.51 (0.93; 2.46)) and ST (individual SES 1.88 (1.12; 3.14) and neighbourhood SES 1.40(0.98; 2.00).ConclusionsLower individual and neighbourhood SES were associated with higher ST. Lower neighbourhood but not individual SES was associated with higher PA. After consideration of school type and school neighbourhood SES associations were attenuated and became insignificant for the relationship between neighbourhood SES, PA and ST. Further research is warranted to unravel the complex relationships between individual SES, neighbourhood SES and school environment to develop more targeted health promotion strategies in the future.
Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a protocol for a scoping review
Authors: Commisso Elana , McGilton Katherine S , Ayala Ana Patricia , Andrew Melissa, K , Bergman Howard , Beaudet Line , Dubé Veronique , Gray Mikaela , Hale Lori , Keatings Margaret , Marshall Emily Gard , McElhaney Janet , Morgan Debra , Parrott Edna , Ploeg Jenny , Sampalli Tara , Stephens Douglas , Vedel Isabelle , Walker Jennifer , Wodchis Walter P , Puts Martine T E 
Published: December 2017

IntroductionPeople are living longer; however, they are not necessarily experiencing good health and well-being as they age. Many older adults live with multiple chronic conditions (MCC), and complex health issues, which adversely affect their day-to-day functioning and overall quality of life. As a result, they frequently rely on the support of friend and/or family caregivers. Caregivers of older adults with MCC often face challenges to their own well-being and also require support. Currently, not enough is known about the health and social care needs of older adults with MCC and the needs of their caregivers or how best to identify and meet these needs. This study will examine and synthesise the literature on the needs of older adults with MCC and those of their caregivers, and identify gaps in evidence and directions for further research.Methods and analysisWe will conduct a scoping review of the peer-reviewed and grey literature using the updated Arksey and O’Malley framework. The literature will be identified using a multidatabase and grey literature search strategy developed by a health sciences librarian. Papers, reports and other materials addressing the health and social care needs of older adults and their friend/family caregivers will be included. Search results will be screened, independently, by two reviewers, and data will be abstracted from included literature and charted in duplicate.Ethics and disseminationThis scoping review does not require ethics approval. We anticipate that study findings will inform novel strategies for identifying and ascertaining the health and social care needs of older adults living with MCC and those of their caregivers. Working with knowledge-user members of our team, we will prepare materials and presentations to disseminate findings to relevant stakeholder and end-user groups at local, national and international levels. We will also publish our findings in a peer-reviewed journal.
Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
Authors: Aung Kyaw L. , Fischer Sandra E. , Denroche Robert E. , Jang Gun-Ho , Dodd Anna , Creighton Sean , Southwood Bernadette , Liang Sheng-Ben , Chadwick Dianne , Zhang Amy , O'Kane Grainne M. , Albaba Hamzeh , Moura Shari , Grant Robert C. , Miller Jessica K. , Mbabaali Faridah , Pasternack Danielle , Lungu Ilinca M. , Bartlett John M.S. , Ghai Sangeet , Lemire Mathieu , Holter Spring , Connor Ashton A. , Moffitt Richard A. , Yeh Jen Jen , Timms Lee , Krzyzanowski Paul M. , Dhani Neesha , Hedley David , Notta Faiyaz , Wilson Julie M. , Moore Malcolm J. , Gallinger Steven , Knox Jennifer J. 
Published: December 2017

Abstract
Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational and transcriptional features for better treatment selection.
Experimental Design: Patients with advanced PDAC were prospectively recruited prior to first-line combination chemotherapy. Fresh tumor tissue was acquired by image-guided percutaneous core biopsy for WGS and RNASeq. Laser capture microdissection was performed for all cases. Primary endpoint was feasibility to report WGS results prior to first disease assessment CT scan at 8 weeks. The main secondary endpoint was discovery of patient subsets with predictive mutational and transcriptional signatures.
Results: Sixty-three patients underwent a tumor biopsy between December 2015 and June 2017. WGS and RNASeq were successful in 62 (98%) and 60 (95%), respectively. Genomic results were reported at a median of 35 days (range, 19–52 days) from biopsy, meeting the primary feasibility endpoint. Objective responses to first-line chemotherapy were significantly better in patients with the classical PDAC RNA subtype compared with those with the basal-like subtype (P = 0.004). The best progression-free survival was observed in those with classical subtype treated with m-FOLFIRINOX. GATA6 expression in tumor measured by RNA in situ hybridization was found to be a robust surrogate biomarker for differentiating classical and basal-like PDAC subtypes. Potentially actionable genetic alterations were found in 30% of patients.
Conclusions: Prospective genomic profiling of advanced PDAC is feasible, and our early data indicate that chemotherapy response differs among patients with different genomic/transcriptomic subtypes. Clin Cancer Res; 24(6); 1344–54. ©2017 AACR.
ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR RISK IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Authors: Smiyan S. I. , Koshak B. O. , Gnatko I. V. 
Published: December 2017

Background. Ankylosing spondylitis is a disease that induces damage to the musculoskeletal system. Mortality rate among patients with AS is in 1.5 times higher than the population level. It is caused by cardiovascular disease and chronic renal failure.Objective. The research was aimed to study the prevalence of endothelial dysfunction and to establish its dependence on the factors of cardiovascular risk in patients with AS.Methods. 104 patients with ankylosing spondylitis (AS) were examined using standard diagnostic methods, such as disease activity, lipidogram, ultrasound of the carotid artery intima media, and endothelium vasodilatation in response to reactive hyperaemia was evaluated. Clinical activity of the disease was determined using the disease activity index BASDAI, BASFI functional index, index BASMI metrology, ASQoL quality of life. To estimate the 10-year risk of cardiovascular disease, the QRISK scale was used.Results. Endothelial dysfunction (ED) was found in 47% cases. It was established that in the patients with ED<10% the incidence of LPL>1.7 mg/L, HDL-C<1.0 mmol/L, TIM thickening>0.9 mm was higher than in the patients with ED>10%. In this group of patients, significant duration of the disease and essential differences in their progress in terms of VAS, CRP, ESR, index activity and functional disorders were revealed.Conclusions. The problem of CVD in patients with AS may be caused by systemic inflammatory disease associated with the development of endothelial dysfunction and increased levels of atherogenic lipids.
Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling
Authors: Krispin Shlomo , Stratman Amber N. , Melick Chase H. , Stan Radu V. , Malinverno Matteo , Gleklen Jamie , Castranova Daniel , Dejana Elisabetta , Weinstein Brant M. 
Published: December 2017

Objective—
The assembly of a functional vascular system requires a coordinated and dynamic transition from activation to maturation. High vascular endothelial growth factor activity promotes activation, including junction destabilization and cell motility. Maturation involves junctional stabilization and formation of a functional endothelial barrier. The identity and mechanism of action of prostabilization signals are still mostly unknown. Bone morphogenetic protein receptors and their ligands have important functions during embryonic vessel assembly and maturation. Previous work has suggested a role for growth differentiation factor 6 (GDF6; bone morphogenetic protein 13) in vascular integrity although GDF6’s mechanism of action was not clear. Therefore, we sought to further explore the requirement for GDF6 in vascular stabilization.

Approach and Results—
We investigated the role of GDF6 in promoting endothelial vascular integrity in vivo in zebrafish and in cultured human umbilical vein endothelial cells in vitro. We report that GDF6 promotes vascular integrity by counteracting vascular endothelial growth factor activity. GDF6-deficient endothelium has increased vascular endothelial growth factor signaling, increased vascular endothelial-cadherin Y658 phosphorylation, vascular endothelial-cadherin delocalization from cell–cell interfaces, and weakened endothelial cell adherence junctions that become prone to vascular leak.

Conclusions—
Our results suggest that GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling. Understanding how GDF6 affects vascular integrity may help to provide insights into hemorrhage and associated vascular pathologies in humans.
Naturally occurring triploids in contact zones between diploid/tetraploid Odontophrynus cordobae and O. americanus (Anura, Odontophrynidae)
Authors: Grenat Pablo , Salas Nancy , Pollo Favio , Otero Manuel , Baraquet Mariana , Sinsch Ulrich , Martino Adolfo 
Published: December 2017

Polyploidization plays an important role in speciation and evolution in anurans. However, a few stable triploid populations and some isolated triploid individuals have been reported. Here, we report the discovery of naturally occurring triploids in contact zones between diploid Odontophrynus cordobae and tetraploid O. americanus from Central Argentina, and propose values of erythrocyte area for the distinction of ploidy levels. A total of 101 individuals from three contact zones were studied and ploidy of each specimen was identified by mean chromosome count and erythrocyte size. Twenty three adult triploid specimens (males: ; females: ) from two contact sites were identified (percentage of individuals per ploidy level: site S2, %, %, %; site S3: %, %, %). The limit values of erythrocyte nuclear area used to distinguish between different ploidy levels were 23.62 μm2 (probability to be assigned to a respective ploidy level = 94.78%) for separating diploids and triploids and 27.67 μm2 (98.62%) for triploids and tetraploids. The high number of adult triploids occurring in more than one contact site between O. cordobae and O. americanus indicates that is not an isolated event. However, further studies are necessary to provide a hypothesis on the origin and evaluate the possible maintenance of triploids in syntopy with O. cordobae and O. americanus.
On Manifestations of the Cult of Human Skulls in the Knÿshovskoe Settlement Dating from the Scythian Period
Authors: Daragan Marina N. , Gavrish Petr A. 
Published: December 2017

AbstractHuman remains have been found in many settlements and fortified settlements of the Scythian period in the forest-steppe zone of the Ukraine. Yet there are substantial differences between the nature of the finds and the circumstances of their positioning in the various settlements concerned. At some sites whole skeletons or parts of skeletons have been found in pits and in habitation levels. At others mainly (and sometimes even exclusively) human skulls or their fragments have been found. A picture of this kind was recorded, in particular, at the fortified settlement of Knÿshovskoe. This article examines the places where human skulls and fragments of the latter were found in the context of cultic and domestic buildings within the Knÿshovskoe settlement. Research was focused specifically on the positions of clay altars and the link between the latter and the anthropological remains within the site. Within the investigated area of the settlement, occupying half a hectare, 110 separate fragments of human skulls were found – 52 altars and 211 pits linked to various structures. Using spatial analysis based ongis-technology, a firm link was established between the clay altars, human skulls and also the skulls or skeletons of dogs, examples of cultic figurines, distaffs and clay cones. The areas in which altars and skulls were concentrated made it possible to regard most of these as having functioned simultaneously in a shrine. Analysis of each specific archaeological find of altars and skulls made it possible to single out certain “archaeological situations” demonstrating clear differences in specific cultic practices, a key component of which was the sacrificing of human heads. The shrine was being used no earlier than the second or third quarter of the 4th centurybc. Establishing the existence of cultic practices involving human sacrifice could provide a crucial step towards an understanding of phenomena, occurring in the forest-steppe zone in the second half and at the end of the 4th centurybc, which eventually led to the complete disappearance of the culture of the Scythian period in the forest-steppe and steppe zones at the end of the 4th centurybc.
Investigation of Atmospheric Rivers Impacting the Pigeon River Basin of the Southern Appalachian Mountains
Authors: Miller Douglas K. , Hotz David , Winton Jessica , Stewart Lukas 
Published: December 2017

Abstract
Rainfall observations in the Pigeon River basin of the southern Appalachian Mountains over a 5-yr period (2009–14) are examined to investigate the synoptic patterns responsible for downstream flooding events as observed near Knoxville, Tennessee, and Asheville, North Carolina. The study is designed to address the hypothesis that atmospheric rivers (ARs) are primarily responsible for the highest accumulation periods observed by the gauge network and that these periods correspond to events having a societal hazard (flooding). The upper 2.5% (extreme) and middle 33% (normal) rainfall events flagged using the gauge network observations showed that half of the heaviest rainfall cases were associated with an AR. Of those extreme events having an AR influence, over 73% had a societal hazard defined as minor-to-major flooding at the USGS river gauge located in Newport, Tennessee, or flooding observations for locations near the Tennessee and North Carolina border reported in the Storm Data publication. Composites of extreme AR-influenced events revealed a synoptic pattern consisting of a highly amplified slow-moving positively tilted trough, suggestive of the anticyclonic Rossby wave breaking scenario that sometimes precedes hydrological events of high impact. Composites of extreme non-AR events indicated a large-scale weather pattern typical of a warm season scenario in which an anomalous low-level cyclone, cut off far from the primary upper-tropospheric jet, was located in the southeastern United States. AR events without a societal hazard represented a large fraction (75%–88%) of all ARs detected during the study period. Synoptic-scale weather patterns of these events were fast moving and had weak low-level atmospheric dynamics.