bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simplification of KDS 14 Design Method for Slab–Column Connections Subjected to Unbalanced Moment
Authors: Dinh Ngoc Hieu , Kim Seung-Hee , Choi Kyoung-Kyu 
Published: October 2024

AbstractThe current KDS 14 design method yields reasonable accuracy with acceptable safety in assessing the unbalanced moment-carrying capacity of slab–column connections. However, the model requires considerable computational effort owing to the effects of various design parameters, particularly the gravity-load effect. This study proposes a method to simplify the KDS 14 model to evaluate the unbalanced moment-carrying capacity of slab–column connections. In the proposed method, the gravity-load effect is decoupled from equations used for evaluating unbalanced moment-carrying capacity components. Subsequently, the total unbalanced moment-carrying capacity is determined by establishing an interaction between the gravity shear ratio and unbalanced moment components without considering the gravity-load effect. For practical design purposes, final simplified design equations are proposed. The reliability of the simplified method is validated based on a comparison with the current KDS 14 design code using a comprehensive database encompassing interior, exterior, and corner slab–column connections. Furthermore, a parametric study based on the proposed simplified approach, current design codes, combined with finite-element (FE) analysis is performed to elucidate the effects of constituents on the unbalanced moment-carrying capacity of corner slab–column connections. The results show that the proposed simplified model and KDS design method are strongly correlated with the experimental and FE results for a range of design parameters. Meanwhile, the ACI 318 model consistently provides a lower limit for strength prediction, thus yielding overly conservative and safe results compared with the test and FE results in most cases.
In-depth characterization of food and environmental microbiomes across different meat processing plants
Authors: Barcenilla Coral , Cobo-Díaz José F. , Puente Alba , Valentino Vincenzo , De Filippis Francesca , Ercolini Danilo , Carlino Niccolò , Pinto Federica , Segata Nicola , Prieto Miguel , López Mercedes , Alvarez-Ordóñez Avelino 
Published: October 2024

Abstract
Background
Processing environments can be an important source of pathogenic and spoilage microorganisms that cross contaminate meat and meat products. The aim of this study was to characterize the microbiome of raw materials, processing environments and end products from 19 facilities producing different meat products.

Results
The taxonomic profiles of the microbial communities evolved along processing, from raw materials to end products, suggesting that food contact (FC) surfaces play an important role in modulating the microbiome of final products. Some species persisted with the highest relative abundance in raw materials, food processing environments and/or in the final product, including species from the genera Pseudomonas, Staphylococcus, Brochothrix, Acinetobacter and Psychrobacter. Processing environments showed a very diverse core microbiota, partially shared with the products. Pseudomonas fragi and Pseudomonas sp. Lz4W (in all sample and facility types) and Brochothrix thermosphacta, Psychrobacter sp. and Psychrobacter sp. P11F6 (in raw materials, FC surfaces and end products) were prominent members of the core microbiota for all facilities, while Latilactobacillus sakei was found as a dominant species exclusively in end products from the facilities producing fermented sausages. Processing environments showed a higher amount of antimicrobial resistance genes and virulence factors than raw materials and end products. One thousand four hundred twenty-one medium/high-quality metagenome-assembled genomes (MAGs) were reconstructed. Of these, 274 high-quality MAGs (completeness > 90%) corresponded to 210 putative new species, mostly found in processing environments. For two relevant taxa in meat curing and fermentation processes (S. equorum and L. sakei, respectively), phylogenetic variation was observed associated with the specific processing facility under study, which suggests that specific strains of these taxa may be selected in different meat processing plants, likely contributing to the peculiar sensorial traits of the end products produced in them.

Conclusions
Overall, our findings provide the most detailed metagenomics-based perspective up to now of the microbes that thrive in meat, meat products and associated environments and open avenues for future research activities to better understand the microbiome functionality and potential contribution to meat quality and safety.
Ontological analysis and disease statistics of wooden coffin paintings from the Qinghai Tibetan Medicine Culture Museum, China
Authors: Li Yanli , Ruan Yuyao , Cailuotai  , Suonanji  , Liu Panpan , Li Yuhu , Xing Huiping 
Published: October 2024

Abstract
The 35 wooden coffin paintings from the Tubo period of the Tang Dynasty, housed in the collection of Qinghai Tibetan Medicine Cultural Museum, are valuable materials for studying Tubo culture. Research has shown that the wood used for coffin paintings was cypress. The adhesives contain bovine collagen and chicken ovalbumin. The pigments used include carbon black, azurite, cinnabar, orpiment, minium, and lead white. This article provides a statistical analysis of the types and areas of diseases that appear in wooden coffin paintings. Through the application of descriptive statistics, correlation coefficient analysis, principal component analysis, and cluster analysis, it was determined that deterioration phenomena such as rotten, crack, pulverization, and discoloration disease were particularly pronounced in coffin paintings. Key variables influencing the disease of wooden coffin paintings include crystal salt, drop, and pulverization. The dataset was categorized into three distinct clusters, each exhibiting significant differences. This study offers valuable insights and foundational support for the future conservation and restoration of coffin paintings.
Impact of biological therapies on clinical outcomes in patients with severe eosinophilic asthma with chronic rhinosinusitis: an observational study from Saudi Arabia
Authors: Abuelhassan Usama E. , Abdalla Abdelrahman M. , Alfaifi Abdulaziz , Kadasah Sultan K. , Alshehri Mohammed A. , Alasiri Haneen A. , Al-Mani Salihah Y. , Kadasah Ali S. , Musleh Abdullah , Alshafa Fawwaz A. , Qureshi Muhammad S. S. , Assiri Abdulmohsen Y. , Falqi Abdulrahman I. , Asiri Bader I. , Ahmed Haider M. O. , Alshehri Saleem , Rahman Fasih U. , Qureshi Muhammad A. , Abdelwahab Omar , Mohamed Sherif , Ali Ahmed R. I. , Alqahtani Saad M. A. , Elnamaky Medhat 
Published: October 2024

Abstract
Background
We aimed to study the impact of biological therapies in Saudi Arabia on patients with severe asthma (SA) combined with chronic rhinosinusitis (CRS) in terms of clinical outcomes.

Methods
This is a retrospective observational cohort research that was undertaken at the severe asthma clinics of the Armed Forces Hospital of the Southern Region (AFHSR) and King Khalid University Hospital, Abha, from March to September 2022 to delineate the effects of 3 biological therapies (dupilumab, benralizumab, and omalizumab) in adults with SA and concomitant CRS. Clinical outcomes assessed included asthma exacerbation frequency, hospitalization rates, use of oral corticosteroids (OCs), and the asthma control test (ACT) scores before and 1 year after biological therapies.

Results
Eighty patients were enrolled, with a mean age of 46.68. There were 45 (56%) females and 35 (44%) males. There was a notifiable decrease in the frequency of exacerbations and hospitalization and in the number of patients who received OCs after 6 and 12 months of biological therapies compared to pre-biological therapies, respectively (p < 0.001 each), while there was a significant increase in the ACT scores at 6 and 12 months post-biological therapies, compared to pre-biological therapies, respectively (p < 0.001). These significant differences were maintained with all the 3 biologics used.

Conclusions
Results from the first study from two large Saudi Arabian tertiary centers for patients with SA and CRS agree with and support those of worldwide real-life ones. One-year follow-up showed the effectiveness of the 3 drugs in terms of reduced frequency of asthma hospitalizations and exacerbations, the use of OCs, and improved ACT scores. Further prospective multicenter studies are warranted.
Development and Implementation of a Geriatric Oncology Interdisciplinary Case–Based Educational Intervention for Cancer Care Providers
Authors: Verduzco-Aguirre Haydee C. , Gomez-Moreno Carolina , Navarrete-Reyes Ana P. , Henriquez-Santos Gretell , Monroy Chargoy Javier , Mateos-Soria Abigail , Sánchez-Hernández Juan José , Castelo-Loureiro Alicia , Hamui-Sutton Liz , Sánchez-Mendiola Melchor , Soto-Perez-de-Celis Enrique 
Published: October 2024

PURPOSE
To develop and implement a continuing professional development (CPD) activity focused on geriatric assessment (GA) in oncology for oncologists and geriatricians. We evaluated the impact of this activity on knowledge, skills, and performance regarding GA in oncology, as well as its feasibility and acceptability.

METHODS

We included teams composed of an oncologist and a geriatrician working in Mexico. Curriculum content was selected from geriatric oncology guidelines. We used Project Extension for Community Healthcare Outcome (ECHO)'s model to create a 12-week online course. A one-group pretest post-test quasi-experimental design was used to evaluate the intervention's effectiveness. At baseline, participants answered a multiple-choice knowledge assessment, a survey on self-perceived competence in GA, and an adaptation of the Association for Community Cancer Centers Geriatric Oncology Gap Assessment Tool, evaluating self-perceived performance in conducting geriatric interventions. These assessments and a satisfaction questionnaire were also completed postintervention. Baseline and postintervention scores were compared using paired
t
-tests.

RESULTS

We included 40 participants (20 oncologists and 20 geriatricians). Median attendance was 10 sessions (range 2-12). Thirty-eight participants completed the satisfaction questionnaire, with a median score of 10/10 (range 8-10). The mean baseline and postintervention knowledge scores were 59.5 ± 12.8 and 74.4 ± 9.7, respectively (
P
< .001, effect size 1.14). The mean baseline and postintervention competence scores were 6.42 ± 2.5 and 9.02 ± 0.8, respectively (
P
< .001, effect size 1.03). The mean baseline and postintervention performance scores were 2.58 ± 0.65 and 3.29 ± 0.5, respectively (
P
< .001, effect size 1.64).

CONCLUSION
A CPD activity for oncologists and geriatricians on the basis of the Project ECHO model was feasible and acceptable, leading to increased knowledge, competence, and performance in geriatric oncology. This could represent a novel method for increasing the geriatric competence of the cancer care workforce in Latin America and globally.
Predictive MINT Pathologic Risk Score for Adjuvant Chemotherapy in Resected Cholangiocarcinoma: A Propensity Score–Matched Multicenter Study in Thailand
Authors: Juengsamarn Jitlada , Sookthon Chatsuda , Jeerapradit Kaewta , Sriudomporn Kanin , Chansitthichok Satsawat , Ouransatien Weeris , Suragul Wikran , Boonpob Sujitra , Sarkhampee Poowanai , Ngamphaiboon Nuttapong 
Published: October 2024

PURPOSE
This study aims to clarify the benefit of adjuvant chemotherapy (AC) in resectable cholangiocarcinoma (CCA) and develop a predictive risk score for treatment selection.

METHODS
Patients with resected CCA undergoing curative surgery, with or without AC, were identified from three centers in Thailand. Patients with R2 resection and 30 days postoperative death were excluded. Using the largest center as the discovery cohort, we generated propensity score matching (PSM). A predictive model for overall survival (OS) was identified, and a predictive risk score was developed from the PSM discovery cohort, classifying patients into high- and low-risk groups. The proposed risk score was validated in the other two centers.

RESULTS

In the discovery cohort, 493 patients were identified. After PSM, 328 patients were categorized into surgery (n = 164) and surgery + AC (n = 164) groups. The baseline characteristics in the PSM discovery cohort were well-balanced. In the validation cohort (n = 83), patients with positive lymph node 1 received AC more frequently than those under observation (47%
v
18%;
P
= .02). A MINT pathologic risk score was developed from multivariate analysis for OS. The score includes margin, perineural invasion, pathologic nodal status, and pathologic tumor size. In the PSM discovery cohort, for the low-risk score group, the surgery group had significantly longer OS compared with the surgery + AC group (49.4
v
31.5 months; hazard ratio [HR], 1.78 [95% CI, 1.11 to 2.86];
P
= .016). Conversely, for the high-risk score group, the surgery + AC group had better OS than the surgery group (18.8
v
8 months; HR, 0.60 [95% CI, 0.46 to 0.79];
P
< .001). The results were comparable in the validation cohort.

CONCLUSION
Patients with resected CCA with a high-risk MINT pathologic risk score were likely to benefit from AC, whereas those with a low-risk score were not. Further validation in a larger prospective cohort is warranted.
Patterns of Care for Brain Metastases in Asia: A Real-World Survey Conducted by the Federation of Asian Organizations for Radiation Oncology
Authors: Uchinami Yusuke , Dasgupta Archya , Nishioka Kentaro , Handoko  , Goda Jayant Sastri , Kim Jun Won , Zaid Rizma Mohd , Kai Yun Ooi , Mehmood Humera , Chitapanarux Imjai , Chopra Supriya , Aoyama Hidefumi 
Published: October 2024

PURPOSE
To report the patterns of care for brain metastases (BMs) in the Federation of Asian Organizations for Radiation Oncology (FARO).

METHODS
Overall, 37 questions were prepared. The survey was conducted online using Google Forms, and the URL was distributed to members of the FARO research committee. Radiation oncologists associated with FARO responded to the questionnaire between May 2023 and June 2023, and their answers were analyzed.

RESULTS
Responses were received from 32 radiation oncologists in 13 countries participating in FARO. Twenty-six physicians (81.3%) were affiliated with academic centers, and 22 (68.8%) were able to perform stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (fSRT) for BMs at their institution. The most typically used prognostic index for BM was the recursive partitioning analysis classification (17 physicians, 53.1%). The maximum number of BMs indicated for SRT/SRS was ≤three (11 physicians, 34.4%), whereas eight (25.0%) physicians answered for 6-10 BMs. The maximum size of BMs considered for SRS/fSRT was ≤3 cm (14 physicians, 43.8%), whereas nine (28.1%) answered that SRS/fSRT was preferred if the maximum size was >4 cm. When whole-brain radiotherapy (RT) was indicated, hippocampal avoidance and memantine usage were limited to 50.0% and 25.0% of patients, respectively. The most typical RT modality after BM resection was SRS/fSRT alone, regardless of whether the margin was positive (19 physicians, 59.4%) or negative (13 physicians, 40.6%).

CONCLUSION
We report the survey results of the patterns of care for BMs in the FARO. This survey was conducted only among a limited number of FARO members. Since many respondents were affiliated with relatively large-scale academic centers, large-scale surveys, including community hospitals, are warranted for future initiatives.
Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort
Authors: Olthof Pim B. , Bouwense Stefan A. W. , Bednarsch Jan , Dewulf Maxime , Kazemier Geert , Maithel Shishir , Jarnagin William R. , Aldrighetti Luca , Roberts Keith J. , Troisi Roberto I. , Malago Massimo M. , Lang Hauke , Alikhanov Ruslan , Ruzzenente Andrea , Malik Hassan , Charco Ramón , Sparrelid Ernesto , Pratschke Johann , Cescon Matteo , Nadalin Silvio , Hagendoorn Jeroen , Schadde Erik , Hoogwater Frederik J. H. , Schnitzbauer Andreas A. , Topal Baki , Lodge Peter , Olde Damink Steven W. M. , Neumann Ulf P. , Groot Koerkamp Bas ,   on behalf of the Perihilar Cholangiocarcinoma Collaboration Group, Bartlett Dm Bartsch F. , Bechstein W. O. , Bednarsch J. , Benzing C. , de Boer M. T. , Buettner S. , Capobianco I. , D’Angelica M. I. , de Reuver P. , de Savornin Lohman E. , Dopazo C. , Efanov M. , Erdmann J. I. , Franken L. C. , Geers J. , Giglio M. C. , Gilg S. , Gomez-Gavara C. , Guglielmi A. , van Gulik T. M. , Hakeem A. , Heil J. , Jansson H. , Kingham T. P. , Maithel S. K , Margies R. , Marino R. , Molenaar Q. I. , Nguyen T. A. , Nooijen L. E. , Nota C. L. M. , Poletto E. , Porte R. J. , Prasad R. , Quinn L. M. , Ratti F. , Ravaioli M. , Rolinger J. , Schmelzle M. , Serenari M. , Sultana A. , Sutcliff R. , Topal H. , van Laarhoven S. , Zonderhuis B. M. 
Published: October 2024

Abstract

Background
Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication management. The aim of this study was to evaluate FTR rates after major liver resection for perihilar cholangiocarcinoma (pCCA) and analyze factors associated with FTR.

Patients and Method
Patients who underwent major liver resection for pCCA at 27 centers were included. FTR was defined as the presence of a Dindo grade III or higher complication followed by death within 90 days after surgery. Liver failure ISGLS grade B/C were scored. Multivariable logistic analysis was performed to identify predictors of FTR and reported using odds ratio and 95% confidence intervals.

Results
In the 2186 included patients, major morbidity rate was 49%, 90-day mortality rate 13%, and FTR occurred in 24% of patients with a grade III or higher complication. Across centers, major complication rate varied from 19 to 87%, 90-day mortality rate from 5 to 33%, and FTR ranged from 11 to 50% across hospitals. Age [1.04 (1.02–1.05) years], ASA 3 or 4 [1.40 (1.01–1.95)], jaundice at presentation [1.79 (1.16–2.76)], right-sided resection [1.45 (1.06–1.98)], and annual hospital volume < 6 [1.44 (1.07–1.94)] were positively associated with FTR. When liver failure is included, the odds ratio for FTR is 9.58 (6.76–13.68).

Conclusion
FTR occurred in 24% of patients after resection for pCCA. Liver failure was associated with a nine-fold increase of FTR and hospital volume below six was also associated with an increased risk of FTR.
Hall current effects on a fully developed combined convection flow in a vertical channel: A study of heat transfer
Authors: Bala A. Jyothi 
Published: October 2024

This paper the effect of magnetic field on free and forced convection flow between two vertical parallel plates is studied. The flow is assumed to be steady and fully developed. The vertical walls are kept at different uniform temperatures. The expression for velocity and bulk temperature are obtained in magnetic and in non-magnetic cases. Hall current effect plays a significant role in determining the flow pattern of an incompressible, viscous, conducting fluid under the influence of an external magnetic field. The effects of magnetic parameter or Hartmann number M, ratio of wall temperature differences (rT), ratio of Grashoff number and Reynolds number , the pressure gradient and the hall parameter (m) is studied numerically on velocity and bulk temperature.
Depression and its associated factors among health care workers in Saint Paul’s hospital millennium medical college, Ethiopia
Authors: Tesema Melese Bahiru , Woldeamanuel Berhanu Teshome , Mekonen Eyoel Berhane , Melese Kidest Getu 
Published: October 2024

Background
Depression is a common mental disorder that affects 3.8% of the general population and 24% of healthcare workers globally. Healthcare professionals are more susceptible to depression because they face higher amounts of professional stress in their jobs and academic lives. However, there is limited knowledge regarding health professionals’ level of depression in Ethiopia. This study aimed to assess the prevalence of depression and associated factors among health professionals, at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Methods
We conducted an institution-based cross-sectional study among 439 randomly selected healthcare workers using interviewer-administered patient health questionnaire-9 from April to May 2023. Ordinal logistic regression was performed to identify predictors of depression. Reported p-values < 0.05 or a 95% Confidence Interval of Odds Ratio excluding one was considered statistically significant.

Result
The overall prevalence of depression among healthcare workers was 21.9% (95%CI: 18%, 27.76%). There were reports of mild (35%), moderate (13%) and severe (9%) depression, respectively. Marital status of being single (AOR = 7.78, 95%CI: 1.123, 49.01), history of childhood abuse (AOR = 2.57, 95%CI:1.49, 4.42), history of suicidal attempt (AOR = 2.66, 95%CI:1.25,5.67), having a history of stressful life event (AOR = 1.527, 95%CI: 1.02,2.3), back pain over the past 30 days (AOR = 2, 95%CI: 1.30,3.11), working for more than 8 hours (AOR = 3.03, 95%CI: 1.12,8.24), and having experience of 5–10 year (AOR = 4, 95%CI: 1.05,15.27) and 10–15 years (AOR = 4.24, 95%CI: 1.08,16.58) and poor social support (AOR = 2.09, 95%CI: 1.09,3.99) were statistically associated with increased level of depression.

Conclusion
Healthcare professionals’ higher rate of depression was due to the higher workload, childhood abuse, history of stressful life, back pain, and poor social support. Thus, the hospital should give special attention to early screening and treatment for depression for those healthcare workers who have a high workload, childhood abuse, back pain, a history of stressful life and poor social support. Similarly, the Ministry of Health should also design strategies to screen, detect and treat depression among healthcare workers.
Translation, cultural adaptation, and validation of the PHQ-9 and GAD-7 in Kinyarwanda for primary care in the United States
Authors: Müller Frank , Hansen Alexis , Kube Megan , Arnetz Judith E. , Alshaarawy Omayma , Achtyes Eric D. , Holman Harland T. 
Published: October 2024

Background
Depression and anxiety are significant health burdens that greatly impact the quality of life of refugees and migrants. In this study, we have translated and culturally adapted the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Screener (GAD-7) into Kinyarwanda and performed a validation study in a United States (US) primary care setting.

Methods
A committee of seven experts including psychiatric and family medicine providers, health researchers, and trained medical interpreters translated and culturally adapted the PHQ-9 and GAD-7, and incorporated feedback from cognitive interviews with bilingual participants. The translated instruments were then tested in a cross-sectional validation study. Analyses include internal consistency, discriminant validity, principal component analyses, and confirmatory factor analyses.

Results
Analyses of 119 responses indicated overall good internal consistency with Cronbach’s α of 0.85 (PHQ-9) and 0.92 (GAD-7). Both scales showed acceptable factor loadings between 0.44 and 0.90 in the principal component analyses and showed strong correlations with health-related quality of life and depression/anxiety symptoms measured with visual analog scales. Significantly higher scores for PHQ-9 and GAD-7 were shown among participants with known psychiatric conditions.

Discussion
PHQ-9 and GAD-7 demonstrated commendable applicability for Kinyarwanda-speaking patients in primary healthcare settings in the US. Our instruments can already be used in primary care settings and thus help to mitigate health disparities. Future research should further validate our tool against gold-standard diagnostics in larger, geographically diverse samples.