bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein
Authors: Liu Zulong , Zhu Hengrui , Qu Shijin , Tang Lisha , Cao Lihuan , Yu Wenbo , Yang Xianmei , Jiang Songmin , Zhu Dayuan , Tan Changheng , Yu Long 
Published: August 2017

Background:
Multi-drug resistance (MDR) remains a major impediment in cancer therapy. A major
goal for scientists is to discover more effective compounds that are able to circumvent MDR and simultaneously
have minimal adverse side effects.

Objective:
In the present study, we aim to determine the anti-MDR effects of pyramidatine (Z88), a cinnamic
acid-derived bisamide compound isolated from the leaves of Aglaia perviridis, on KB/VCR (vincristineresistant
human oral cancer cells) and MCF-7/ADR (adriamycin-resistant human breast adenocarcinoma) cells.

Methods:
Cell viability and average resistant fold (RF) of Z88 were examined by Cell Counting Kit-8 (CCK-8)
assay. Flow cytometry, western blot, RT-PCR, Rhodamine 123 accumulation assay and P-glycoprotein (P-gp)
ATPase assay were used to demonstrate the anti-MDR activity and mechanism of Z88.

Results:
The average RF of Z88 is 0.09 and 0.51 in KB/VCR and MCF-7/ADR cells. A CCK-8 assay showed
that Z88 could enhance the cytotoxicity of VCR toward KB/VCR cells. A FACS analysis revealed that Z88
could enhance the VCR-induced apoptosis as well as G2/M arrest in a dose-dependent manner in KB/VCR cells.
Western blot results showed that the expression levels of PARP, Bax, and cyclin B1 all increased after treatment
with 0.2 µmol/L (µM) of VCR combined with 10 µM of Z88 for 24 h in KB/VCR cells. Z88 also could enhance
the accumulation of rhodamine 123. Further studies showed that Z88 could inhibit the verapamil stimulated Pgp
ATPase activity. Additionally, qPCR detection and western blot assays revealed that Z88 could decrease the
expression of P-gp at both RNA and protein level.

Conclusion:
Z88 exerted potent anti-MDR activity in vitro and its mechanisms are associated with dualinhibition
of the function and expression of P-gp. These findings encourage efforts to develop more effective
reversal agents to circumvent MDR based on Z88.
Recycling nutrients from horse manure: effects of bedding type and its compostability
Authors: Keskinen Riikka , Saastamoinen Markku , Nikama Johanna , Särkijärvi Susanna , Myllymäki Marianna , Salo Tapio , Uusi-Kämppä Jaana 
Published: August 2017

Manure constitutes a nutrient resource that should be efficiently recycled in agriculture. We assessed the nutrient cycling properties of three bedding materials (peat, wood shavings and pelleted straw) in horse manure by comparing their compostability, ability to retain nitrogen (N) and phosphorus (P) under rainfall and capacity to release N when mixed with soil. Manure with pelleted straw bedding had superior composting characteristics as it lost half of its dry mass, reached temperatures >60 °C and ended up having a carbon (C) to N (C:N) ratio of <15. In percolated water, 4–11% of total manure N and 5–23% of total manure P was leached during a 2 h 15 min event of artificial rainfall. Peat manure was most susceptible to P loss. In all fresh manures, C:N ratio exceeded 30, which led to net N immobilization in soil. Composting decreased the C:N leading to a slight positive or an insignificant fertilizer effect.
Como diferentes grupos resolvem problemas combinatórios condicionais e não-condicionais?
Authors: Lima Ewellen , Gadelha Dacymere , Borba Rute 
Published: August 2017

O presente estudo foi desenvolvido coletivamente junto a estudantes de Pedagogia e buscou investigar o desempenho, apresentado por oito grupos distintos, no que diz respeito à resolução de problemas combinatórios condicionais e não-condicionais. O instrumento de coleta utilizado foi composto por oito situações-problema, sendo duas de cada tipo de problema combinatório – produto cartesiano, arranjo, permutação e combinação – uma condicional e outra não. A existência das condições foi percebida e levada em consideração pela maioria dos participantes. Os problemas de produto cartesiano apresentaram maior número de acertos nos diferentes grupos pesquisados, enquanto nos de combinação foram obtidos os menores percentuais de acertos. Além disso, o desempenho foi superior nos problemas condicionais em todos os grupos. Atribui-se esse resultado à existência de maior número de possibilidades nos problemas não-condicionais e ao amplo uso de estratégias informais, como a listagem, que dificultou o esgotamento das possibilidades.
Palavras-chave: Educação Matemática. Combinatória. Problemas Condicionais. Problemas Não-condicionais.
Skrining Potensi Andrografolid dari Sambiloto (Andrographis paniculata (Burm F.) Ness.) sebagai Antikanker Payudara secara In Silico
Authors: Laksmiani N. P. L. , Widiastari M. I. , Reynaldi K. R. 
Published: August 2017

Kandungan utama yang dimiliki oleh tanaman sambiloto (Andrographis paniculata (Burm. F.) Ness.) yaitu andrografolid merupakan senyawa golongan diterpen lakton yang diketahui memiliki berbagai aktivitas salah satunya sebagai antikanker. Salah satu penyebab terjadinya kanker payudara yaitu adanya ekspresi berlebih dari protein Human Epidermal Receptor-2 (HER-2) yang dapat menginduksi terjadinya dimerisasi dan autofosforilasi sehingga memicu terjadinya aktivasi Focal Adhesion Kinase (FAK) yang dapat mengakibatkan migrasi dan metastasis pada sel kanker payudara. Tujuan penelitian ini adalah untuk mengetahui mekanisme penghambatan ekspresi berlebih dari protein HER-2 oleh senyawa andrografolid secara in silico dengan menggunakan molecular docking.
Metode in silico seperti molecular docking dilakukan dengan melalui beberapa tahapan seperti validasi metode, optimasi struktur senyawa andrografolid 3D, docking antara senyawa andrografolid teroptimasi dengan protein HER-2 yang mengacu pada parameter energi ikatan dimana semakin rendah nilai energi ikatan maka semakin kuat dan stabil ikatan yang terjadi antara senyawa andrografolid dengan protein HER-2
MODEL BIAYA PEMELIHARAAN FASILITAS PADA BANDAR UDARA NGURAH RAI BALI
Authors: Dewita Reni , Adnyana Putera I G. A. , Putu Suparsa I G. 
Published: August 2017

Facilities in an airport requires maintenance activity in order to achieve excellent quality level and able to support activities at the airport to avoid negative impacts, which is the declining quality of the facility that can lead to lower levels of the productivity carried out in an airport. Maintenance facilities at Bali's Ngurah Rai airport need the maintenance costs planning. To get proper maintenance actions, the maintenance costs early stages of planning phase needs to develop a model of facility maintenance costs that can provide the maintenance costs estimates quickly and accurately. To produce a maintenance costs model we should identify the maintenance activities that exist at Ngurah Rai airport. Maintenance costs data used is within the last 5 years (2007-2011). Using the Cost Significant Model methode and the linear regression equation it showed that several of the facility maintenace significantly affect the facility maintenance costs in the Ngurah Rai Airport which is the cost of passenger terminal building maintenance (X6), the cost of runway maintenance (X1), the cost of taxiway maintenance (X2), the cost of air conditioning installation maintenance (X14), the cost of road maintenance (X4), the cost of vehicle parking maintenance (X5), and the cost of navigation and communication equipment maintenance (X10). There is 3 linear regression equation model which is 1) Y = 11873745878,77 + 0,993 X1 + 0,826 X2 + 0,334 X4 + 1,181 X6, 2) Y = -698840481,94 + 1,327 X1 + 1,716 X2 + 5,516 X5+ 3,060 X14, and 3) Y = 82110363478,07 + 1,013 X1 - 17,223X5 + 22,406 X10 - 12,035 X14. After doing the Cost Model Factor (CMF) test to the three linear regression equation, the most accurate equation is linear regression equation Y = 82110363478,07 + 1,013 X1 - 17,223X5 + 22,406 X10 - 12,035 X14 that has the average ratio 0.006% of the actual cost, so it is the best facility maintenance cost model at Bali's Ngurah Rai Airport.
ANALISIS DAMPAK PELAKSANAAN CAR FREE DAY DI KOTA DENPASAR Studi kasus: Jalan Raya Puputan Niti Mandala Renon
Authors: Decy Arwini Ni Putu , Negara I N. Widana , Suthanaya I P. Alit 
Published: August 2017

Abstract: Renon area is the center of the goverment system of Bali province. As one of the main street in Denpasar city, this street can represent the characteristics of Denpasar city which is the Car Free Day was held in in every Sunday morning in this street, as a simple way to reduce the air pollution and noise. The calculation in this journal is road performance, air pollution and noise level for 2 condition that is in Car Free Day and in working day. From the calculation result of road performance, the capacity of the street is 4.110 pcu/hour with degree of saturation is 0,8. The level of street service is on D category where the flow is almost unstable with high volume of traffic. The traffic volume is mostly reached the capacity and delay is frequently occur in this street. The measurement process of the level of air pollution showed that from six parameter which tested were over all are still under the standard quality which is allowed as good and medium category. The Sulfur dioksida (SO2) which was measured in busy day showed the improvement about 6,78% from the measurement which is done in Car Free Day. The nitrogen dioksida showed the improvement for about 36,35% , the carbon monoksida also showed the improvement for about 366,25%, the total dust had the greatest improvement for about 599,95% or six time greater rather than the level of total dust in Car Free Day. In the other hand, oxidantshowed the improvement for about 28,75%.The noises which occured in Car Free Day showed the average level of dB(A)is 61,65 whereas in workdays showed 72,77 dB(A). At 07.30 until 07.45 in the morning , the maximum level of noises occurs in Car Free Day and in work day. The noises improvement which occured when the Car Free Day was held with workday is about 19,17%.
STUDI EKSPERIMENTAL TENTANG KEKUATAN DINDING BATA DENGAN PERKUATAN
Authors: Pascanawaty Maya Saridewi , Sukrawa M , Budiwati I.A M 
Published: August 2017

Abstract: Experimental study on the strength of brick walls have been done through literature review and laboratory testing to determine flexural, compressive and shear behaviour of the walls. Four different type of walls were used consisted of walls without plastering (TP), walls with plastering (DP), walls with plastering and chicken mesh reinforcement (DPK), and walls with plastering and wire mesh M4 reinforcement (DPW). The behaviour examined included load-deformation relationship and crack pattern/mode of failure. Laboratory testing included compression test (C) namely CTP, CDP, CDPK and CDPW; bond/shear strength test (S) namely STP, SDP, SDPK, and SDPW; flexural strength tests for failure plane perpendicular to bed joints (F) namely FTP?, FDP?, FDPK?, and FDPW?; and flexural strength tests for failure plane parallel to bed joints, namely FTP//, FDP//, FDPK// and FDPW//. Prior to testing the wall, tests on constituent materials were conducted. Red brick (made in Negara) showed compressive strength of 11,03 N/mm² with water absorption of 21,84%. Compressive strength of mortar was 9,1 N/mm². For the wall specimens testing was done after 28 days. The data obtained from the wall tests showed that compression strength for CTP, CDP, CDPK and CDPW are 3,82 N/mm², 3,84 N/mm², 7,46 N/mm², and 6,33 N/mm², respectively. Values for CDP, CDPK and CDPW are 1,01; 1,95; and 1,86 greater than that for CTP. Bond strength values of STP, SDP, SDPK and SDPW are 0,11 N/mm², 0,28 N/mm², 0,54 N,mm², and 0,42 N/mm², respectively. Values for SDP, SDPK and SDPW are 2,58; 4,88; and 3,87 greater than that of STP. Flexural strength values of FTP? and FDP? are 0,93 N/mm² and 1,27 N/mm², with a failure load for FTP?, FDP?, FDPK?, and FDPW? are sebesar 8,17 KN, 25,17 KN, 31,17 KN and 40,67 KN, respectively. The values for FDP?, FDPK?, and FDPW? are 3,08; 3,82; and 4,98 greater than that of FTP?. Flexural strength values of FTP// and FDP// are 0,38 N/mm² and 0,66 N/mm², with a failure load for FTP//, FDP//, FDPK//, and FDPW// are 3,5 KN, 13,67 KN, 18,33 KN and 32,83 KN, respectively. The values for FDP//, FDPK//, and FDPW// are 3,9; 5,24; and 9,38 greater than that of FTP//. The flexural strength of FDPK and FDPW that’s not analyzed because it was a shear failure and not a flexural failure. Stiffness (EA) for CTP, CDP, CDPK, and CDPW are 725,09 KN, 1096,32 KN, 2357,64 KN, and 1869,78 KN, respectively. The last three values are 1,5; 3,3; and 2,6 greater than that for CTP. Stiffness (EI) of FTP? was 23,78 KNm2, while stiffness of FDP?, FDPK? and FDPW? are 68,68 KNm2, 96,31 KNm2 and 112,17 KNm2, respectively, or 2,9; 4,0; and 4,7 greater than that for FTP?. Stiffness (EI) of FTP// was 12,99 KNm2, while stiffness of FDP//, FDPK//, and FDPW// were 46,89 KNm2, 84,53 KNm2 and 119,51 KNm2, respectively, or 3,6; 6,5; and 9,2 greater than that for FTP//.
EFEKTIVITAS PENGELOLAAN IRIGASI DENGAN SUMUR POMPA GUNA MENINGKATKAN POLA TANAM DI KECAMATAN NEGARA, KABUPATEN JEMBRANA
Authors: Putra Wiryawan Agus Gede , Norken I N , Purbawijaya IBN 
Published: August 2017

Abstrack : Jembrana Regency especially Negara District have two river caracteristics such as the river which located in western Melaya River only flow when the rainy season and the rivers located between western Klatakan river and eastern Pulukan river flow every years with low discharge. it caused failing of harvest. So the ground water used to supply the surface water needs. But, complaint comes from the farmer caused by the expensive cost of operational generating set. The approach doing by study and research directly to the well pump which located in Negara district. Purposive sampling used to determine the respondents in this quisionaires. Likert scale used to measure attitudes, opinon and perceptions from the respondents on data analyzed by descriptive qualitative. The research showed resource, subak organization, operational and maintenance generating set, pump, and financial. Work on 82% reaching effectiveness of irrigation management with pump well in Negara district. And, based on result of double linier regression simultaneous and partial, showed that the significant effect to effectiveness of irrigation management with pump well in Negara district, Jembrana regency.
HUBUNGAN KOMPETENSI PROJECT MANAGER TERHADAP KEBERHASILAN PROYEK KONSTRUKSI GEDUNG
Authors: Brahmantariguna Ida Ayu Ari , Dharmayanti GAP. Candra , Yansen I W. 
Published: August 2017

Abstract :One of the factor that influences the achievement of a project success is the role of a project manager. A reliable project manager, who knows his duties as a project leader and has the necessary competency requirements is needed to achieve the success of the project. The competence of a project manager can be measured by three aspects: knowledge, skill and attitude.This research aims to analyze the relationship between project manager competencies (that measured by three independent variables, i.e. Knowledge, skills and attitude) and the success of the building construction project. Data was collected through a questionnaire survey. The sample/ respondents were the expertise in the field of building construction services those acts as a project manager. Data was analyzed in three stages:first, factor analysis to reduce the variables into several groups of factors, that called as independent variables; second, correlation test with Pearson Correlation method to determine the correlation between independent variables and dependent variable; lastly, perform multivariate regression analysis The results of factor analysis showed that the variables are formed into eleven groups, and the result of Pearson Correlation test showed only six groups correlated to project success, those are: Communication and Scope Management, Human Resource Management, which is part of knowledge; Leadership and Project Management, Professionalism and Issues Management as part of skill; and attitude concerning Responsibility, Vision and Priorities. The sixth group of these factors will be the independent variables in multivariate regression analysis. Based on multiple correlation test results, six independent variables simultaneously have a significant influence to the project success, proved by the result of probability value is 0,032.
Urgensi Kecerdasan Emosional guna Menentukan Keberhasilan Peserta Didik dalam Proses Pembelajaran
Authors: Musodiq Agus 
Published: August 2017

Penelitian ini diproyeksikan untuk memaparkan kecerdasan emosional yang dimiliki oleh Nabi Musa di dalam Surat al-Qasas. Mengingat bahwa keberhasilan seseorang dalam menggapai suatu keinginan tertentu di dalam kehidupan nyatatidak hanya ditentukan oleh kecerdasan kognitif saja. akan tetapi diperlukan kecerdasan emosional yang sangat menentukan keberhasilan tersebut. Di dalam teori kecerdasan emosional yang dirumuskan Golemann, terdapat lima dasar kecakapan emosi dan sosial yang meliputi (1) kesadaran diri. Mengetahui apa yang kita rasakan pada suatu saat dan menggunakannya untuk mengambil keputusan, (2) penguasaan diri.mampu pulih dari tekanan emosi dengan cepat, (3) motivasi dapat mengendalikan emosi ketika mendapatkan kegagalan, menggerakan hasrat untuk menuju ke sasaran, (4) empati; merasakan apa yang dirasakan oleh orang lain, mampu memahami perspektif mereka, (5) keterampilan sosial; menangani emosi dengan baik ketika berhubungan dengan orang lain dengan cermat memahami situasi dan jaringan social. penelitian ini juga akan dibantu dengan teori semiotika Charles S. Peirce untuk dapat menganalisi tanda bahasa yang menggambarkan kecerdasan emosional Nabi Musa as. Berdasarkan penelitian yang telah dilakukan, diketahui bahwa Allah menggambarkan kecerdasan emosional dan sosial pada diri Nabi Musa secara berurutan, yakni dimulai dari ayat ke 14 hingga ayat ke 35. Nabi Musa yang dikirim Allah untuk membimbing dan memimpin Bani Israil dibekali dengan kecerdasan emosional dan sosial yang sangat mengagumkan. Beliau dapat memotivasi dirinya sendiri, berempati, dapat mengurangi keagresifan diri, dan kemampuan-kemampuan lain yang membantu Musa “berprestasi” dalam memimpin Bani Israil, terlepas dari penafsiran, dan anggapan lain yang bertentangan dengan apa yang diinterpretasikan oleh peneliti. Dengan demikian dapat disimpulkan bahwa makna argument dari kisah Musa di dalam Surat al-Qasas adalah seluruh pemimpin yang “berprestasi” memiliki kecerdasan emosional dan sosial.
Kata Kunci: Kecerdasan Emosional, Proses Pembelajaran.
Implementasi Aplikasi Telemedicine Berbasis Jejaring Sosial dengan Pemanfaatan Teknologi Cloud Computing
Authors: Jamil Mohamad , Khairan Amal , Fuad Achmad 
Published: August 2017

Ide tentang pemeriksaan dan evaluasi kesehatan dengan menggunakan perangkat jaringan telekomunikasi perkembangannya semakin hari semakin meningkat, karena kemajuan di bidang multimedia, imaging, komputer, sistem informasi dan telekomunikasi, salah satunya adalah telemedicine. Secara umum telemedicine adalah penggunaan teknologi informasi dan komunikasi yang digabungkan dengan kepakaran medis untuk memberikan layanan kesehatan, mulai dari konsultasi, diagnosa dan tindakan medis, tanpa terbatas ruang atau dilaksanakan dari jarak jauh. Untuk dapat berjalan dengan baik, sistem ini membutuhkan teknologi komunikasi yang memungkinkan transfer data berupa video, suara, dan gambar secara interaktif yang dilakukan secara real time dengan mengintegrasikannya ke dalam teknologi pendukung video-conference. Termasuk sebagai teknologi pendukung telemedicine adalah teknologi pengolahan citra untuk menganalisis citra medis. Di Indonesia perkembangan teknologi telemedicine menjadi terhambat dikarenakan keterbatasan infrastruktur dan layanan teknologi informasi yang dimiliki belum memadai. Tujuan dari penelitian ini adalah mendesain dan merealasasikan arsitektur aplikasi telemedicine berbasis jejaring sosial dengan pemanfaatan teknologi cloud computing Kata Kunci— Telemedicine, Cloud Computing, E-Health, Internet
Integrasi Protokol SMS dan Internet pada Mobile Banking
Authors: Yusmanto Muhammad , Albarda Albarda 
Published: August 2017

Pertumbuhan pengguna gadget dan smartphone yang semakin pesat mendorong Bank menyediakan layanan mobile banking untuk meningkatkan jumlah pengguna yang melakukan transaksi perbankan. Namun pemanfaatan terhadap implementasi mobile banking di Indonesia masih dirasakan terdapat kekurangan. Oleh karena itu, pada paper ini dirancang suatu sistem aplikasi yang dapat mengatasi kekurangan dan menjawab kebutuhan pengguna dan bank. Sebagai studi awal, ditinjau sistem mobile banking dari salah satu bank dilihat dari sudut pandang pengguna. Dari hasil analisis didapat bahwa sistem yang dapat mengatasi kekurangan dan sesuai dengan kebutuhan adalah sistem mobile banking terpadu yang memanfaatkan jalur internet dan SMS, dimana sistem dapat mengubah jalur komunikasi yang digunakan sesuai dengan kondisi yang ada, dengan prioritas jalur internet. Sistem berupa mobile app dimana fungsi perpindahan ada pada mobile app itu sendiri. Pada implementasi tugas akhir ini, dihasilkan mobile app pada OS Android. Ada dua fitur utama yaitu pengecekan jaringan dan perpindahan jalur komunikasi, dimana hanya pengecekan jaringan yang berhasil diimplementasikan. Kata kunci - gadget, mobile banking, mobile app, jaringan terpadu
Penerapan Metode ADAM Pada Proses Investigasi Layanan Private Cloud Computing
Authors: Widiyasono Nur , Riadi Imam , Luthfi Ahmad 
Published: August 2017

Layanan Private Cloud Computing memiliki potensi terjadinya penyalahgunaan yang dilakukan oleh internal di dalam perusahaan, sebagai contoh kasus yang yang terjadi di RSIA XYZ. Penyalahgunaan tersebut terjadi dikarenakan adanya kelemahan sistem yang digunakan ,ataupun sebab lain. Proses akuisisi data pada layanan cloud computing penanganannya tidaklah sama dikarenakan jenis dan karakteristik layanan cloud computing tersebut. Isu mengenai masalah realibilitas data atau bagaimana proses data digital evidence didapatkan, pada persidangan akan menjadi perhatian khusus bagi majelis hakim, sehingga untuk menangani masalah tersebut digunakanlah metode ADAM (The Advance Data Acquisition Model), sayangnya metode tersebut belum pernah dilakukan evaluasi secara independen. Penelitian ini menggunakan metode ADAM di dalam melakukan investigasi kasus pada layanan private cloud computing dan telah berhasil 100% menerapkannya, kemudian kontribusi pada penelitian ini telah menemukan penyebab potensi terjadinya penyalahgunaan layanan aplikasi owncloud tersebut. Kata kunci— Akusisi, ADAM, Cloud, Forensik, Investigasi