bluuebunny/crossref_metadata_2025_split huggingface dataset:
A genome-wide association study of occupational creativity and its relations with well-being and career success
Authors: Li Wen-Dong , Zhang Xin , Yu Kaili , Zhu Yimo , Du Nianyao , Song Zhaoli , Fan Qiao 
Published: September 2024

AbstractCreativity is one defining characteristic of human species. There have been mixed findings on how creativity relates to well-being, and little is known about its relationship with career success. We conduct a large-scale genome-wide association study to examine the genetic architecture of occupational creativity, and its genetic correlations with well-being and career success. The SNP-h2 estimates range from 0.08 (for managerial creativity) to 0.22 (for artistic creativity). We record positive genetic correlations between occupational creativity with autism, and positive traits and well-being variables (e.g., physical height, and low levels of neuroticism, BMI, and non-cancer illness). While creativity share positive genetic overlaps with indicators of high career success (i.e., income, occupational status, and job satisfaction), it also has a positive genetic correlation with age at first birth and a negative genetic correlation with number of children, indicating creativity-related genes may reduce reproductive success.
Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids
Authors: Schöbel Anja , Pinho dos Reis Vinicius , Burkhard Rabea , Hehner Julia , Schneider Laura , Schauflinger Martin , Vieyres Gabrielle , Herker Eva 
Published: September 2024

AbstractViruses depend on host metabolic pathways and flaviviruses are specifically linked to lipid metabolism. During dengue virus infection lipid droplets are degraded to fuel replication and Zika virus (ZIKV) infection depends on triglyceride biosynthesis. Here, we systematically investigated the neutral lipid–synthesizing enzymes diacylglycerol O-acyltransferases (DGAT) and the sterol O-acyltransferase (SOAT) 1 in orthoflavivirus infection. Downregulation of DGAT1 and SOAT1 compromises ZIKV infection in hepatoma cells but only SOAT1 and not DGAT inhibitor treatment reduces ZIKV infection. DGAT1 interacts with the ZIKV capsid protein, indicating that protein interaction might be required for ZIKV replication. Importantly, inhibition of SOAT1 severely impairs ZIKV infection in neural cell culture models and cerebral organoids. SOAT1 inhibitor treatment decreases extracellular viral RNA and E protein level and lowers the specific infectivity of virions, indicating that ZIKV morphogenesis is compromised, likely due to accumulation of free cholesterol. Our findings provide insights into the importance of cholesterol and cholesterol ester balance for efficient ZIKV replication and implicate SOAT1 as an antiviral target.
Bio-responsive polymers for dual 31P/19F-magnetic resonance to detect reactive oxygen species in vivo
Authors: Jirát-Ziółkowska Natalia , Sulková Kateřina , Kracíková Lucie , Androvič Ladislav , Havliček Dominik , Laga Richard , Jirák Daniel 
Published: September 2024

AbstractBiocompatible metal-free agents are emerging as a promising alternative to commercial magnetic resonance (MR) contrast agents, but there is an additional need for novel probes with enhanced responsiveness in preclinical MR testing to effectively target diverse pathological conditions. To address this, we develop hydrophilic phospho-/fluoropolymers as dual MR probes. Incorporating thiophosphoester groups (P = S) into the polymer structure produces a distinct chemical shift (~59 ppm) in phosphorus MR (31P-MR), reducing biological signals interference. Reactive oxygen species (ROS) oxidize the P = S groups, causing a detectable shift in 31P-MR, enabling precise localization of ROS, abundant in inflammation and cancer. To enhance this capability, bioinert trifluoromethyl groups (CF3) are added, creating a “hotspot” for fluorine MR (19F-MR), aiding in vivo localization. Both in vitro and in vivo testing demonstrate the probe’s high specificity and responsiveness, underscoring its potential as a sensitive ROS sensor and dual MR-traceable tool in cancer research.
Mechanically rigid metallopeptide nanostructures achieved by highly efficient folding
Authors: Kang Xing , Wang Li , Liu Bingyu , Zhou Shuyi , Li Yingguo , Yang Shuai-Liang , Yao Rui , Qiao Liang , Wang Xiao , Gong Wei , Liu Yan , Shi Leilei , Dong Jinqiao , Cui Yong , Davis Anthony P. 
Published: September 2024

Abstract
Natural proteins must fold into complex three-dimensional structures to achieve excellent mechanical properties vital for biological functions, but this has proven to be exceptionally difficult to control in synthetic systems. As such, the long-standing issue of low mechanical rigidity and stability induced by misfolding constrains the physical and chemical properties of self-assembling peptide materials. Here we introduce a mixed-chirality strategy that enhances folding efficiency in topologically interlocked metallopeptide nanostructures. The orderly entanglement of heterochiral peptide-derived linkers can fold into a compact three-dimensional catenane. These folding-mediated secondary structural changes not only generate biomimetic binding pockets derived from individual peptide strands but also result in strong chiral amplification by the tight interlocking manner. Notably, this strategic ‘chirality mutation’ alters their arrangement into tertiary structures and is pivotal in achieving exceptional mechanical rigidity observed in the metallopeptide crystals, which exhibit a Young’s modulus of 157.6 GPa, approximately tenfold higher than the most rigid proteinaceous materials in nature. This unusual nature is reflected in enhanced peptide-binding properties and heightened antimicrobial activities relative to its unfolded counterpart.
Aktuelles zu Tätowierfarben und regulatorischen Vorgaben: Bedeutung für die allergologische Abklärung
Authors: Schubert Steffen , Hauri Urs , Wolf Carina , Karst Uwe , Siewert Katherina , Schreiver Ines 
Published: September 2024

Zusammenfassung
Hintergrund Ungefähr 18% der Weltbevölkerung sind tätowiert – besonders bei (jüngeren) Frauen sind permanente Tattoos und Permanent Make-up beliebt. Seit Januar 2022 müssen Tätowierfarben die Vorgaben des Tattoo-spezifischen Beschränkungseintrags in der EU-REACH-Verordnung einhalten. Dieser Artikel analysiert die Folgen am Markt aus allergologischer Sicht.
Material und Methoden Recherche zu Inhaltsstoffen und Rechtsvorschriften im Bereich von permanenten Tätowierungen in Pubmed, Fachbüchern, auf einschlägigen Webseiten, beim World Congress of Tattoo and Pigment Research 2023 und in einem Tattoo-Studio.
Ergebnisse Der Tattoo-spezifische Beschränkungseintrag in der EU-REACH-Verordnung legt Grenzwerte für Chemikalien fest, die gemäß EU-CLP-Verordnung harmonisiert als krebserzeugende, mutagene, reproduktionstoxische, hautsensibilisierende oder hautreizende Substanzen eingestuft wurden. Außerdem dürfen bekannte Stoffe, die in den Anhängen II und IV der EU-Kosmetikverordnung gelistet sind, nur noch sehr begrenzt in Tätowierfarben eingesetzt werden. Auf der einen Seite können Kontrollbehörden durch diese Grenzwerte die Einhaltung der gültigen Rechtsvorschriften für Tätowiermittel besser kontrollieren. Auf der anderen Seite wurden diese Grenzwerte teilweise ohne wissenschaftliche Evidenz für eine Gefährdung festgelegt. Es ist bislang unklar, inwiefern sich bspw. das Sensibilisierungspotenzial von Kontaktallergenen durch die dermale Applikation beim Tätowiervorgang ändert.Seit Inkrafttreten der erweiterten EU-REACH-Verordnung werden viele Substanzen eingesetzt, die im Tattoo-Bereich bisher nicht in Erscheinung getreten sind und problematisch sein könnten. Beispiele sind Pigment Blau 61 und Pigment Gelb 155, die entweder Anilin oder p-Phenylendiamin enthalten. Der Einsatz von Kolophonium und von Formaldehydabspaltern wurde durch die Festsetzung von niedrigen Grenzwerten de facto verboten. Der Grenzwert für Aldehyde ist technisch im Moment nicht erreichbar und erschwert die Herstellung steriler, REACH-konformer Tätowierfarben. Durch die Verknüpfung zur EU-CLP-Verordnung können bestimmte Konservierungsmittel, die eigentlich ein vielsprechendes toxikologisches Profil aufweisen, in Zukunft nicht (mehr) eingesetzt werden.
Fazit In Zukunft gilt es, Datenlücken mit In-vitro-Labormethoden und klinisch-epidemiologischen Daten zu schließen und auf dieser Basis regulatorische Vorgaben anzupassen. Dem Allergen-Monitoring, z.B. im Rahmen der IVDK Tattoo Studie 2.0, kommt dabei eine Schlüsselstellung zu. Epikutantestempfehlungen sollten kontinuierlich an Änderungen auf dem Tätowierfarbenmarkt angepasst werden.
Triglyceride Glucose Index and the Risk of Diabetic Nephropathy in
Patients with Type 2 Diabetes: A Meta-Analysis
Authors: Deng Sheng , Peng Ling 
Published: September 2024

AbstractDiabetic nephropathy (DN) is a leading cause of end-stage renal disease in
patients with type 2 diabetes mellitus (T2DM). This meta-analysis aims to
evaluate the association between the triglyceride glucose (TyG) index, a novel
marker reflecting insulin resistance, and the risk of developing DN in patients
with T2DM. We conducted a comprehensive literature search in PubMed, Embase, and
Web of Science databases up to May 12, 2024. Studies assessing the TyG index in
relation to DN risk among T2DM patients were included. The pooled relative risks
(RRs) with 95% confidence intervals (CIs) were calculated using a random-effects
model. A total of eight longitudinal follow-up studies encompassing 15 889
patients with T2DM were included. The pooled analysis revealed a significant
association between a higher TyG index and an increased risk of DN in patients
with T2DM (RR=1.53, 95% CI: 1.37–1.71, p<0.001; I2=35%). The
results of meta-regression analysis suggested that the cutoff of TyG index was
positively associated with the RR for the association between TyG index and DN.
Subgroup analyses demonstrated that the association was stronger in studies with
cutoff of TyG index ≥9.5 as compared to those with the cutoff <9.5 (RR: 1.73
vs. 1.40, p for subgroup difference <0.05). The association was not
significantly affected by study design, mean age of the patients, proportion of
men, or follow-up durations. In conclusion, higher TyG index is significantly
associated with an increased risk of DN in patients with T2DM.
Recent Advances in Fluoroalkylation Strategies: Exploring Novel Reactivities and Synthetic Applications of Sulfone- and Sulfinate-Based Reagents for Mono-, Di-, and Trifluoromethylations
Authors: Prakash G. K. Surya , Knieb Alexander 
Published: September 2024

AbstractFluoroalkylation serves as a pivotal strategy for chemists to precisely alter the properties of small molecules. Among the established fluoroalkylation protocols, sulfone and sulfinate reagents stand out as versatile tools for these reactions, particularly in mono-, di-, and trifluoromethylations. Their versatility lies in offering multiple pathways, encompassing electrophilic, nucleophilic, as well as radical mechanisms, thus providing diverse routes for controlled molecular modifications through a variety of very exciting mechanistic paths.1	Introduction2	Monofluoromethylation Strategies2.1	Fluorobis(phenylsulfonyl)methane (FBSM)2.2	2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide (FBDT)2.3	Benzothiazole-SO2CH2F, NaSO2CH2F, and ClSO2CH2F2.4	PhSO2CH2F3	Difluoromethylation Strategies3.1	PhSO2CF2H3.2	Benzothiazole-SO2CF2H3.3	2-PyrSO2CF2H3.4	NaSO2CF2H4	Trifluoromethylation Strategies4.1	PhSO2CF3
4.2	2-PyrSO2CF3
4.3	Benzothiazole-SO2CF3
4.4	NaSO2CF3
4.4.1	Electrochemical Approaches4.4.2	Photochemical Approaches4.4.3	Other Noteworthy Approaches5	Conclusion
Clinical Study of 35 Patients with Acute Acoustic Hearing Disorder
Authors: Saiki Tadahiko , Ogawa Teruhiro , Haruna Takenori , Kuroda Kazuaki 
Published: September 2024

AbstractWe conducted a clinical study on 35 patients (42 ears) with acute acoustic hearing disorder who visited the otolaryngology department of Himeji St. Mary's Hospital during 12 years, from January 2012 to December 2023. The patients' ages ranged from 16 to 81 years, with an average of 34.7 years (median age: 27 years); there were 27 male and 8 female patients. The disease was caused by exposure to shooting sounds in 22 patients (shooting sound group) and exposure to other strong and loud sounds in the remaining 13 patients (other high-intensity sound group). The mean age was significantly lower, and the interval from the onset of symptoms to consultation was shorter in the shooting sound group than in the other high-intensity sound group. Regarding hearing type, the C5-dip type was the most common (11 ears), followed in frequency by the gradually down-sloping, sharply down-sloping, and flat type. The overall hearing improvement was as follows: cured: 40.5%; markedly recovered: 11.9%; recovered: 19.0%; and unchanged: 28.6%. The degree of hearing improvement classified by hearing type was good for all of the C5-dip, dip (2K), and V-shaped types. Patients younger than 30 years, with a short interval from the onset to first visit, and with bilateral hearing loss showed satisfactory hearing improvement. There was a tendency for the degree of hearing improvement to be better in the shooting sound group than in the other high-intensity sound group.
Noninvasive Encapsulated Papillary Carcinoma of the Breast with Nodal Micrometastasis: A Rare Entity
Authors: Bhat Shubha Padmanabha , Vijayan Pooja , Srinivas Teerthanath , Kamat Premananda 
Published: September 2024

AbstractPapillary neoplasms of the breast are rare and often pose diagnostic challenges to pathologists in routine practice. Encapsulated papillary carcinoma (EPC) of the breast is a rare type of papillary neoplasm. This tumor presents in postmenopausal women. Sonomammogram will aid in locating and identifying it as a cystic lesion. Fine needle aspiration cytology will help in diagnosing the papillary nature of the lesion. Surgical excision is the treatment of choice. Histopathology is necessary for accurate diagnosis. In rare circumstances, noninvasive EPC can have axillary nodal metastasis. We report the case of a 52-year-old woman who came with complaints of a lump in the left breast. This lump was radiologically suspected to be a phyllodes tumor. Fine needle aspiration cytology helped in identifying the lesion as papillary neoplasm. Histopathological examination revealed noninvasive encapsulated papillary carcinoma with axillary lymph node micrometastasis.
A Descriptive Study to Assess the Unhealthy Lifestyle among Perimenopausal Women in a Selected Medical College Hospital, Mangaluru
Authors: Miranda Janet Prima , Adhikari Prabha , C. Binsha Pappachan 
Published: September 2024

Abstract
Introduction The perimenopausal phase, also known as the menopausal transition, marks a crucial period in a woman's life, characterized by hormonal fluctuations and physiological changes. During this transitory period, lifestyle factors are critical in influencing health outcomes. Lifestyle Appraisal focuses on identifying the lifestyle factors and habits that may affect a woman's health throughout the perimenopausal period.
Methods and Materials The objective of the study was to identify perimenopausal women with unhealthy lifestyle practices using a lifestyle appraisal questionnaire. The study used descriptive design to determine the unhealthy lifestyle among perimenopausal women in the age group of 45 to 55 years. A complete enumerative sampling was used to select the 148 participants who fulfilled the inclusion criteria. Every participant completed the self-reported lifestyle assessment questionnaire (LAQ), except for the questions where the researcher measured blood pressure, height, and weight (body mass index [BMI]) with standard protocol.
Results Unhealthy lifestyle habits persist in women. The average lifestyle appraisal score was 19.17 ± 6.88, ranging from 8 to 35. The higher the score, the unhealthy their lifestyle. The tool's highest possible score is 73. The majority of the subjects did not engage in regular exercise (43.9%), recreational activities (62.8%), or relaxation exercises (81.1%). A substantial number (54.1%) of women had encountered one to two stressful events in the last 6 months, with friends and family occasionally available for support (64.7%). None of them received love and affection every day, but rather on an occasional basis (69.6%). Most (81.1%) reported consuming meals with fruits and vegetables only two to three times a week, while fatty foods or sweets were ingested daily (60.1%). Furthermore, most (45.3%) participants were classified as overweight, with a BMI falling between 23 and 24.9.
Conclusion Simple screening methods can be used to evaluate health and lay the groundwork for understanding a person's lifestyle, which helps preserve and encourage a healthy way of life.
The Spectrum of Self-Limited Infantile Epilepsy Syndromes
Authors: Saadeldin Imad Yassin , Matlik Hussein Naseer , Mohammed Hiba , Abdelmagid Tayseer A. M. , Babikir Haydar El Hadi 
Published: September 2024

AbstractInfantile epilepsy syndromes' nomenclature has changed over time. The International League Against Epilepsy (ILAE) revised its 2021 classification and definition of epilepsy syndromes in neonates and infants, replacing the term “benign” with “self-limited,” and now identifies them as “self-limited infantile epilepsy” (SeLIE). SeLIE is characterized by seizures that begin during infancy and resolve spontaneously with normal developmental progress. The recognition of infantile seizures with favorable outcomes dates back more than 60 years, as noted by Fukuyama in Japan. Thirty years later, Watanabe et al reported benign focal seizures in infancy, with the majority of cases being nonfamilial. These seizures' self-limited nature during infancy has since been acknowledged in various countries, spanning diverse ethnic populations beyond Japan. Infants who undergo such seizures are now recognized as having self-limited nonfamilial infantile epilepsy (SeLNFIE). Initially, Vigevano et al detailed the familial variant in five infants, coining the term “benign familial infantile seizures” to characterize this condition, now known as self-limited familial infantile epilepsy (SeLFIE). SeLNFIE and SeLFIE may present similarly with the exception of a positive family history. After the initial description and classification of these syndromes (familial and nonfamilial) in the ILAE's 1989 Classification of Epilepsies and Epileptic Syndromes, several less frequently encountered related syndromes have been recognized. These conditions comprise a spectrum including SeLFIE with choreoathetosis and paroxysmal dyskinesia, now termed infantile convulsions with paroxysmal choreoathetosis syndrome (ICCA); self-limited focal epilepsy in infancy with midline spikes and waves during sleep (SeLIMSE); self-limited infantile seizures with mild gastroenteritis (SeLISwG); SeLFIE associated with familial hemiplegic migraine (FHM); and self-limited familial neonatal-infantile epilepsy (SeLFNIE). This review aims to document the prevalence of these SeLIEs, elucidate their unique characteristics, and underscore their self-limited nature.
A general problem-solving matrix (GPSM): combining crime prevention and public health tools
Authors: Eck John E. , Ceccato Vania , Guerette Rob T. 
Published: September 2024

AbstractCrime involves different individuals interacting in complex social and physical settings. Often, crime problem solvers reach for a common generic response, when they need to consider a number of possible solutions. Thinking tools can help. In this article, we show how uniting an injury prevention tool—the Haddon Matrix used widely in public health—and a crime prevention tool—the crime problem triangle used widely in policing—can provide guidance to crime problem solvers. We call our hybrid the General Problem-Solving Matrix (GPSM). We apply GPSM to rape and burglary to illustrates its features. We conclude the article by examining the alternative versions of GPSM in crime prevention.
Addressing the role of eHealth literacy in shaping popular attitudes towards post-COVID-19 vaccination among Chinese adults
Authors: Jiao Wen , Schulz Peter Johannes , Chang Angela 
Published: September 2024

AbstractThis study examined the influence of eHealth literacy on Chinese individuals’ attitudes towards post-COVID-19 vaccination and explored methods to address obstacles related to eHealth literacy that could affect their comprehension and willingness to get vaccinated. In 2022, a web-based cross-sectional survey was conducted to assess the vaccination-related knowledge, attitudes and intentions of 950 participants. Vaccination knowledge was established by employing validated measures and conducting a Mokken scale analysis. Causal-directed acyclic graphs were used to illustrate the current comprehension of the correlation between eHealth literacy and the desire to receive vaccinations. This study utilised causal mediation and multiple linear regression analysis to determine the relationships between eHealth literacy, vaccination knowledge, vaccination willingness and subjective health status. The primary finding of this study was that an individual’s comprehension of vaccination was a robust indicator of their inclination to receive vaccination. Moreover, eHealth literacy has an indirect effect on the propensity to get vaccinated by enhancing one’s understanding of vaccines. This study emphasises the significant role of eHealth literacy in enhancing vaccination awareness and willingness, particularly among Chinese adults with poorer health in the post-COVID-19 period. The results affirm the efficacy of employing eHealth technologies to bolster immunisation initiatives, amplify vaccine consciousness, and promote compliance. Moreover, this study emphasises the significance of additional research to assess and record the function of eHealth literacy in immunisation practices.
Optimizing process parameters to minimize wear-induced material loss in bronze-based hybrid metal matrix composites using the Taguchi method
Authors: R. Sreenivasa , B. T. Ramesh , Giri Jayant , Al-Sadoon Mohammad Khalid , Bongale Arun Kumar , Sathish T. , Banagar Ashok R. 
Published: September 2024

Metal matrix composites have captured considerable interest in tribological applications, largely owing to their remarkable characteristics, which include a high strength-to-weight ratio and a low wear rate. This investigation delves into the exploration of hybrid metal matrix composites, where cobalt and chromium play the role of reinforcing agents within a bronze foundation. These composites were manufactured through a powder metallurgy process, utilizing cobalt and chromium metal powders with a particle size of 40 μm. Various weight percentage ratios (2.5%, 5.0%, and 7.5%) were utilized to create these composite specimens. To assess their tribological performance, the composite samples were subjected to a sliding wear test using a pin on disk machine, following the ASTM G99 standards. The wear characteristics of these composites were analyzed using the Taguchi method, considering parameters such as the applied load, speed, reinforcement percentage, and sliding distance. In addition, we conducted an analysis of variance on the collected data. To analyze the wear behavior of these hybrid metal matrix composites based on bronze, we utilized both multiple linear regression analysis and a signal-to-noise ratio assessment. The results indicate that the inclusion of cobalt and chromium metal powders as reinforcement materials enhances the tribological properties of the bronze matrix material.