bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ups and downs of geology in Portugal: the Geological Survey, a historical perspective
Authors: Mota Teresa Salomé , Carneiro Ana 
Published: May 2016

Abstract
The Geological Survey of Portugal was created in 1857 in the context of a liberal monarchy within a general policy implemented by the state to effectively control Portuguese territory. Throughout the nineteenth century, despite the structural problems faced by the Survey, it developed a consistent geological research programme, which led to the publication of two editions of the geological map of Portugal on a scale of 1:500 000, together with a considerable number of related scientific articles and monographs. During the first three decades of the twentieth century, however, the Survey and the production of maps were no longer a priority for the State and the institution progressively declined. Only with the establishment of the dictatorial regime known as the Estado Novo (New State) and, in particular, the implementation of its industrializing policies in the context of development plans, did the Geological Survey recover its original purpose of producing geological maps and assert itself as a reference scientific institution.
A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma
Authors: Rampling Roy , Peoples Sharon , Mulholland Paul J. , James Allan , Al-Salihi Omar , Twelves Christopher J. , McBain Catherine , Jefferies Sarah , Jackson Alan , Stewart Willie , Lindner Juha , Kutscher Sarah , Hilf Norbert , McGuigan Lesley , Peters Jane , Hill Karen , Schoor Oliver , Singh-Jasuja Harpreet , Halford Sarah E. , Ritchie James W.A. 
Published: May 2016

AbstractPurpose: To perform a two-cohort, phase I safety and immunogenicity study of IMA950 in addition to standard chemoradiotherapy and adjuvant temozolomide in patients with newly diagnosed glioblastoma. IMA950 is a novel glioblastoma-specific therapeutic vaccine containing 11 tumor-associated peptides (TUMAP), identified on human leukocyte antigen (HLA) surface receptors in primary human glioblastoma tissue.Experimental Design: Patients were HLA-A*02–positive and had undergone tumor resection. Vaccination comprised 11 intradermal injections with IMA950 plus granulocyte macrophage colony-stimulating factor (GM-CSF) over a 24-week period, beginning 7 to 14 days prior to initiation of chemoradiotherapy (Cohort 1) or 7 days after chemoradiotherapy (Cohort 2). Safety was assessed according to NCI CTCAE Version 4.0 and TUMAP-specific T-cell immune responses determined. Secondary observations included progression-free survival (PFS), pretreatment regulatory T cell (Treg) levels, and the effect of steroids on T-cell responses.Results: Forty-five patients were recruited. Related adverse events included minor injection site reactions, rash, pruritus, fatigue, neutropenia and single cases of allergic reaction, anemia and anaphylaxis. Two patients experienced grade 3 dose-limiting toxicity of fatigue and anaphylaxis. Of 40 evaluable patients, 36 were TUMAP responders and 20 were multi-TUMAP responders, with no important differences between cohorts. No effect of pretreatment Treg levels on IMA950 immunogenicity was observed, and steroids did not affect TUMAP responses. PFS rates were 74% at 6 months and 31% at 9 months.Conclusions: IMA950 plus GM-CSF was well-tolerated with the primary immunogenicity endpoint of observing multi-TUMAP responses in at least 30% of patients exceeded. Further development of IMA950 is encouraged. Clin Cancer Res; 22(19); 4776–85. ©2016 AACR.See related commentary by Lowenstein and Castro, p. 4760
Size-assortative copulation in the simultaneously hermaphroditic pond snail Radix auricularia (Gastropoda: Pulmonata)
Authors: Yu Tong Lei , Deng Yao Hui , Zhang Juan , Duan Li Peng 
Published: May 2016

To better understand the importance of body size in hermaphroditic mating, we studied the mating behaviour of the pond snail Radix auricularia. This simultaneous hermaphrodite exhibits a positive correlation between body size and egg production and provides weak evidence for size-assortative mating. In addition to this mating pattern, the partner performing the male role was significantly smaller than the mounted partner, performing the female role. In this study, two laboratory experiments were done to test whether body size has (1) an effect on mate choice of the sperm donor, and (2) poses mechanical constraints. These snails did not display physical limitation in mating with a much larger or smaller partner. In the mate choice experiment, we found no evidence for significant preferences for large partners. Therefore, mate choice of sperm donor and mechanical constraints are not likely to contribute to the formation of size-assortatively mating pairs in this species, which contributes to understanding about how these processes work in hermaphrodites.
Narrative and Ideology
Authors: Houston Sam 
Published: May 2016

With its focus on “narrative” and theology as an ethnographic enterprise, the “postliberalism” of Hans W. Frei and George A. Lindbeck sought to incorporate insights from the linguistic turn in modern thought. However, it has faced criticisms ranging from sectarianism to concern with its overly static and homogeneous conceptions of “narrative” and “Christian community” that fail to recognize the church’s participation in many overlapping communities of discourse. In this essay, I explore such criticisms and their recognition of the varied narratives and discursive practices by which Christian communities are formed, in ways both recognized and unrecognized. I then examine the work of Ugandan Catholic theologian Emmanuel Katongole which gives due attention to “narrative” and ideology, and in doing so, demonstrates “postliberal” theology’s insights while also compensating for its weaknesses.
Impact of Assimilating Wind Profiling Radar Observations on Convection-Permitting Quantitative Precipitation Forecasts during SCMREX
Authors: Zhang Xubin , Luo Yali , Wan Qilin , Ding Weiyu , Sun Jiaxiang 
Published: May 2016

AbstractTo improve the prediction of heavy rainfall in southern China during the prerainy season, horizontal wind data from wind profiling radars (WPRs) were assimilated in the partial-cycle data assimilation (DA) system based on a three-dimensional variational method. The analyses from the DA system are used as initial conditions for the convection-permitting Global/Regional Assimilation and Prediction System (GRAPES) model. The impact of assimilating WPR data on the quantitative precipitation forecast (QPF) in southern China was evaluated over the period of the Southern China Monsoon Rainfall Experiment (SCMREX) in May 2014, by comparing the results of a control experiment with WPR data assimilated and a denial experiment without WPR data. The positive impact of WPR DA was significant on the forecasts of atmospheric variables in the vertical and diagnostic fields at the surface, especially those of surface wind fields in the 0–6-h range. The inclusion of WPR data also improved the QPF skill of light and heavy rainfall throughout the 12-h forecast period by reducing the predicted spurious precipitation (thereby alleviating overestimations and false alarms), with the largest improvement in 6-h heavy rainfall forecasts. WPR DA considerably alleviated the spinup problem, remarkably improving the QPF of heavy rainfall (especially extreme rainfall). The improved representation of wind and moisture at lower levels in the analyses due to WPR DA was the physical cause of the QPF improvement, as is illustrated using a case study.
Mobile Endoscopy vs Video Tower
Authors: Liu Hao , Akiki Salwa , Barrowman Nicholas J. , Bromwich Matthew 
Published: May 2016

ObjectiveTo determine if any significant difference exists between endoscopic videos captured with a mobile adaptor and videos captured with a traditional tower.Study DesignProspective controlled blinded comparison of mobile endoscopic videos captured through 2 methods.MethodsThirty randomly selected patients underwent video endoscopy with both mobile and video tower recording methods. Sixty videos were edited into a series of 10‐second clips. Thirteen otolaryngology staff and residents rated the video quality and provided a diagnosis for each video.ResultsWe found no significant difference in the video quality ratings between mobile and tower videos (mean difference, −0.07; P <. 37). Similarly, we found no significant difference in the observers’ diagnostic accuracy (mean difference, 1.54%; P <. 686).ConclusionWith adequate power, our study was unable to demonstrate a difference between mobile adapter videos and tower videos. Our findings suggest that mobile adapter videos may reasonably be used in lieu of tower videos in clinical practice.
VAVD vacuum may cause bubble transgression in membrane oxygenators
Authors: Nygaard K , Thiara AS , Tronstad C , Ringdal MA , Fiane AE 
Published: May 2016

Background: Vacuum-assisted venous drainage (VAVD) is widely used to enhance venous blood return from patients undergoing cardiopulmonary bypass (CPB). This vacuum can accidentally reach the oxygenator of the heart-lung machine and draw gas bubbles into the blood. This is known as bubble transgression (BT) and may cause air emboli in the arterial blood line. In order to avoid BT and minimize the risk of patient injury, knowledge of oxygenator tolerance to vacuum load is critical. Thus, the main aim of this thesis was to investigate how much vacuum a membrane oxygenator can withstand before BT appears. Methods: We investigated four different adult oxygenators: Quadrox-i, Affinity Fusion, Capiox RX25 and Inspire 6M. They were tested in an in vitro setup where VAVD vacuum was allowed to reach the oxygenator through a non-occlusive roller pump. An ultrasonic clinical bubble counter, Gampt BCC 200, was used to count bubbles on the arterial line when the arterial pump was restarted. Results: We observed a significant increase in bubble count for two of the oxygenators, caused by -30 mmHg of VAVD vacuum in the blood reservoir (Affinity Fusion and Inspire 6M). Massive air ingress was shown in two of the oxygenators, caused by -30 mmHg of VAVD vacuum in the reservoir (Capiox RX25) and -40 mmHg of VAVD vacuum in the reservoir (Affinity Fusion). Conclusion: VAVD vacuum may cause bubble transgression in an oxygenator. This was shown for all the oxygenators in this test. VAVD vacuum may cause visible massive air ingress in an oxygenator. This was shown for two of the oxygenators in this test (Capiox RX25 and Affinity Fusion). An alarm triggering on negative pressure in the oxygenator or a pressure relief valve might improve safety when using VAVD.
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novelATP1A2mutation
Authors: Pelzer N , Blom DE , Stam AH , Vijfhuizen LS , Hageman ATM , van Vliet JA , Ferrari MD , van den Maagdenberg AMJM , Haan J , Terwindt GM 
Published: May 2016

BackgroundFamilial hemiplegic migraine (FHM) is a rare monogenic migraine subtype characterised by attacks associated with transient motor weakness. Clinical information is mainly based on reports of small families with only short follow-up. Here, we document a prospective 15-year follow-up of an extended family with FHM type 2.Patients and methodsAfter diagnosing FHM in a patient with severe attacks associated with coma and fever, we identified eight more family members with FHM and one with possible FHM. All family members were prospectively followed for 15 years. In total 13 clinically affected and 21 clinically non-affected family members were genetically tested and repeatedly investigated.ResultsA novel p.Arg348Pro ATP1A2 mutation was found in 14 family members: 12 with clinical FHM, one with psychomotor retardation and possible FHM, and one without FHM features. In 9/12 (75%) family members with genetically confirmed FHM, attacks were severe, long-lasting, and often associated with impaired consciousness and fever. Such attacks were frequently misdiagnosed and treated as viral meningitis or stroke. Epilepsy was reported in three family members with FHM and in the one with psychomotor retardation and possible FHM. Ataxia was not observed.ConclusionFHM should be considered in patients with recurrent coma and fever.
Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
Authors: Sabatino Marianna , Hu Jinhui , Sommariva Michele , Gautam Sanjivan , Fellowes Vicki , Hocker James D. , Dougherty Sean , Qin Haiying , Klebanoff Christopher A. , Fry Terry J. , Gress Ronald E. , Kochenderfer James N. , Stroncek David F. , Ji Yun , Gattinoni Luca 
Published: May 2016

Key Points
A platform for the generation of clinical-grade CD19-CAR–modified TSCM. CD19-CAR–modified TSCM mediate superior antitumor responses compared with CD19-CAR T cells currently used in clinical trials.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade
Authors: Watson Amanda J. , Hopkins Gemma V. , Hitchin Samantha , Begum Habiba , Jones Stuart , Jordan Allan , Holt Sarah , March H. Nikki , Newton Rebecca , Small Helen , Stowell Alex , Waddell Ian D. , Waszkowycz Bohdan , Ogilvie Donald J. 
Published: May 2016

RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid carcinomas where both germline and sporadic activating somatic mutations are prevalent. At present, there are no known specific RET inhibitors in clinical development, although many potent inhibitors of RET have been opportunistically identified through selectivity profiling of compounds initially designed to target other tyrosine kinases. Vandetanib and cabozantinib, both multi-kinase inhibitors with RET activity, are approved for use in medullary thyroid carcinoma, but additional pharmacological activities, most notably inhibition of vascular endothelial growth factor - VEGFR2 (KDR), lead to dose-limiting toxicity. The recent identification of RET fusions present in ~1% of lung adenocarcinoma patients has renewed interest in the identification and development of more selective RET inhibitors lacking the toxicities associated with the current treatments. In an earlier publication [Newton et al, 2016; 1] we reported the discovery of a series of 2-substituted phenol quinazolines as potent and selective RET kinase inhibitors. Here we describe the development of the robust screening cascade which allowed the identification and advancement of this chemical series. Furthermore we have profiled a panel of RET-active clinical compounds both to validate the cascade and to confirm that none display a RET-selective target profile.
Individual Matrixes of Values As Basis for Social Group Members’ Behavior Correction
Authors: Фролов  , Frolov S. 
Published: May 2016

Management on values represents very perspective area of activity concerning the human relations
management. Consequently, in this paper the author analyzes individual matrixes of values as a basis for
social group members’ behavior management. At the same time questions related to social norms correction
within ordered series of cultural values are considered.
Book Reviews
Authors: Shen Wenjing 
Published: May 2016

In Book Reviews, we review an extensive and diverse range of books. They cover theory and applications in operations research, statistics, management science, econometrics, mathematics, computers, and information systems. In addition, we include books in other fields that emphasize technical applications. The editor will be pleased to receive an email from those willing to review a book, with an indication of specific areas of interest. If you are aware of a specific book that you would like to review, or that you think should be reviewed, please contact the editor. The following books are reviewed in this issue of Interfaces, 46(3), May–June 2016: Inequality: What Can Be Done?, Anthony B. Atkinson; and R for Marketing Research and Analytics, Chris Chapman and Elea McDonnell Feit.
ON-LINE IRRADIATION TESTING OF A GIANT MAGNETO-RESISTIVE (GMR) SENSOR
Authors: Olfert Jeffrey , Luloff Brian , MacDonald Dan , Lumsden Robert 
Published: May 2016

Magneto-resistive sensors are rapidly gaining favour for magnetic field sensing applications owing to their high sensitivity, small size, and low cost. Their metallic, nonsemiconductor construction makes them excellent candidates for use in the harsh environments present in nuclear and space applications. In this work, a commercially available magneto-resistive sensor was irradiated up to a total gamma dose of 2 MGy (200 Mrad), and online testing was performed to monitor the sensor throughout the irradiation to detect any degradation. No significant evidence of degradation of the sensor characteristics was observed. A very small (< 1%) change in the bridge balance of the sensor as a function of accumulated dose was detected.
Wasted youth in the hospitality industry: Older workers’ perceptions and misperceptions about younger workers
Authors: Mooney Shelagh 
Published: May 2016

Abstract
In many western contexts, although young people form a high proportion of the hospitality workforce, perceptions of hospitality work as temporary and unpredictable rather than an aspirational career choice means turnover is very high. The aim of the study on which the article is based was to investigate why people build and maintain long careers working in hospitality. This article focuses on the career experiences of young workers in the industry, viewed from the perspective of older workers in long-term hospitality careers. An intersectional methodology explored how youthful body-age, at times interacting with other aspects of socially ascribed difference, is reflected in work-place organizational processes. The findings suggest that younger workers in hospitality are not valued and the discussion addresses the ways in which inequitable power relations create this status quo. The conclusion is that the hospitality sector should retain its youthful workers, rather than wasting this finite human resource.
Musicological analysis of guitar solos from the roots of rock through modern heavy metal
Authors: Slaven James E. , Krout Jody L. 
Published: May 2016

Abstract
The general techniques of guitar soloing have changed very little since the beginnings of the rock era in the 1950s, even though the style of playing has seen dramatic changes. Using the methods of analysis from the fields of statistics and musicology, we have looked into how soloing techniques have changed from 1950s’ rock to modern heavy metal. This not only helps in discerning the differences in playing between eras but is an addition to the toolbox of musicology. Pitch distributions were calculated and then analysed using cluster and tree methods. Speed and technique were analysed using the Generalized Estimating Equations. We found no distinct delineation between the decades for pitch distributions. There was an increasing, though non-significant, trend in the use of special techniques, which became significant when comparing the later decades grouped against the earlier decades. Most notably, there was a significant difference in speed between the decades, with an increase in the later decades.
Vulnerability, brutality, hope: Complexism and the 56th Venice Biennale
Authors: Tromble Meredith 
Published: May 2016

Abstract
Exploring an aesthetics of complexity relevant to contemporary art, the artist/author discusses the 56th Venice Biennale, curated by Okwui Enwezor, in light of Philip Galanter’s essay ‘Complexism and the role of evolutionary art’. Artworks by Steve McQueen, Isaac Julien, Mika Rottenberg, Hito Steyerl, Im Heung-Soon, Katrīna Neiburga and Andris Eglītis are related to concepts of emergence, chaos, feedback, generative process, and networks, and writings by philosopher Manuel Delanda, sociologist Saskia Sassen and physicist James P. Crutchfield. As one of the most influential international exhibitions of contemporary art, the Venice Biennale is considered a bellwether of future trends; this edition called ‘All the World’s Futures’ presents artwork in context with a dissolving binary paradigm of communism/capitalism that fails to adequately address labour, environmental and immigration issues. The author concludes that an approach informed by complexity theory holds more promise, aesthetically and politically.
The effect of centrifugation speed and time on pre-analytical platelet activation
Authors: Söderström Anna C. , Nybo Mads , Nielsen Christian , Vinholt Pernille J. 
Published: May 2016

Abstract

Background:
The results of laboratory analyses are affected by pre-analytical variables, and in particular can platelets be activated by shear handling stress and secrete granular substances. We therefore evaluated the effect of centrifugation speed and time on pre-analytical platelet activation.

Methods:
Citrate- and EDTA-anticoagulated blood from healthy volunteers were centrifuged at 80–10,000 g for 5–15 min to prepare plasma and platelet-rich plasma. Pre-analytical platelet activation was assessed by flow cytometric measurement of platelet P-selectin (CD62p) expression. Blood cell counts, mean platelet volume (MPV), immature platelet fraction (IPF), and platelet distribution width (PDW) were measured. Platelet aggregation in platelet-rich plasma induced by arachidonic acid (AA), ADP or thrombin receptor activator peptide-6 (TRAP) was tested by 96-well aggregometry.

Results:
The median percentage of platelets expressing P-selectin in citrate- and EDTA-plasma centrifuged at 2000 g for 10 min were 43% [interquartile range (IQR), 38%–53%] and 56% (IQR, 31%–78%), respectively (p=0.82). Platelet-rich plasma prepared at 100–250 g for 10 min had significantly lower platelet P-selectin expression (11%–15%), p<0.001. Platelet count in plasma samples decreased with increasing speed but platelets were only completely removed if plasma was re-centrifuged. In platelet-rich plasma, increasing centrifugation speed significantly increased platelet yield but decreased contamination from other blood cells, platelet composition was altered as platelet parameters (MPV, IPF, and PDW) was lowered. Platelet aggregation was not affected by the centrifugation speed platelet-rich plasma was prepared.

Conclusions:
Proportional to centrifugation speed, platelets in plasma and platelet-rich plasma were activated with centrifugation speed, cell content and composition changed while platelet aggregation was unaltered.
Comparison of site effect values obtained by HVSR and HVSRN methods for single-station measurements in Tarnówek, South-Western Poland.
Authors: Mendecki Maciej J. , Bieta Barbara , Mateuszów Mateusz , Suszka Paweł 
Published: May 2016

Abstract
This study compares the HVSR technique (Horizontal to Vertical Spectral Ratio), based on seismic event records, and the HVSRN technique (Horizontal to Vertical Spectral Ratio of Noise) using seismic noise registrations. Both methods allow us to study the amplification phenomenon of a horizontal component of seismic waves when the waves reach loose sediments in subsurface layers. The seismic data were measured at a three-component single seismic station located in the village of Tarnówek, in the Legnica-Głogów Copper District. The results of the study demonstrate that average HVSRN and HVSR maxima can be distinguished: for periods approximately 3.78 s (H/V = 6.2) and 3.969 s (H/V = 8.98) respectively. The evaluated share of the Rayleigh wave component in the recorded values was β = 0.58 and it can be suggested that the Love wave share in surface motion was insignificant. The Love wave share remains unknown.