bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEACOIN 2.0 – an interactive mining and visualization tool for information retrieval, summarization, and knowledge discovery
Authors: Uppal Karan , Lee Eva K. 
Published: October 2017

ABSTRACTMotivationThe rapidly increasing size of biomedical databases such as MEDLINE requires the use of intelligent data mining methods for information extraction and summarization. Existing biomedical text-mining tools have limited capabilities for inferring topological and network relationships between biomedical terms. Very often too much is returned during summarization leading to information overload.ResultsWe present herein SEACOIN 2.0, an interactive knowledge discovery and hypothesis generation tool for biomedical literature.SEACOIN generates k-ary relational networks of biomedical terms using a novel term ranking scheme to facilitate efficient information retrieval, summarization, and visual data exploration. Summarization is presented via multiple dynamic visualization panels. We evaluate the system performance in information retrieval and features extraction using the BioCreative 2013 Track 3 learning corpus. An average F-measure of 94% was achieved for document retrieval and an average precision of 88% was achieved for identification of top co-occurrence terms. The system allows interactive mining of complex implicit and explicit relationships among biomedical entities (genes, chemicals, diseases/disorders, mutations, etc.) and provides a framework for hypothesis generation. It also improves our understanding of various biological processes and disease mechanisms.Contacteva.lee@gatech.edu
MHD three dimensional double diffusive flow of Casson nanofluid with buoyancy forces and nonlinear thermal radiation over a stretching surface
Authors: Gireesha B.J. , Archana M. , B.C. Prasannakumara , Gorla R.S. Reddy , Makinde Oluwole Daniel 
Published: October 2017

Purpose
This paper aims to deal with the study of heat and mass transfer on double-diffusive three-dimensional hydromagnetic boundary layer flow of an electrically conducting Casson nanofluid over a stretching surface. The combined effects of nonlinear thermal radiation, magnetic field, buoyancy forces, thermophoresis and Brownian motion are taken into consideration with convective boundary conditions.

Design/methodology/approach
Similarity transformations are used to reduce the governing partial differential equations into a set of nonlinear ordinary differential equations. The reduced equations were numerically solved using Runge–Kutta–Fehlberg fourth-fifth-order method along with shooting technique.

Findings
The impact of several existing physical parameters such as Casson parameter, mixed convection parameter, regular buoyancy ratio parameter, radiation parameter, Brownian motion parameter, thermophoresis parameter, temperature ratio parameter on velocity, temperature, solutal and nanofluid concentration profiles are analyzed through graphs and tables in detail. It is found that the solutal component increases for Dufour Lewis number, whereas it decreases for nanofluid Lewis number. Moreover, velocity profiles decrease for Casson parameter, while the Nusselt number increases for Biot number, radiation and temperature ratio parameter.

Originality/value
This paper is a new work related to three-dimensional double-diffusive flow of Casson nanofluid with buoyancy and nonlinear thermal radiation effect.
Medical and allied health staff self-reported long-term conditions
Authors: Smyth Wendy , Lindsay David , Brennan Daryl , Lindsay Daniel 
Published: October 2017

Purpose
The purpose of this paper is to describe the self-reported long-term conditions of medical officers and allied health staff working in a regional public health service in northern Australia and how these conditions are managed.

Design/methodology/approach
A cross-sectional survey design was used. The sample was all medical officers and allied health staff employed in mid-2015.

Findings
Of the 365 respondents, 217 (59.5 per cent) reported having at least one long-term condition. There was a statistically significant association between professional group and the number of long-term conditions reported, χ2=10.24, p<0.05. A greater proportion of medical officers (n=29, 43.9 per cent) reported having only one long-term condition compared with allied health staff (n=36, 24.5 per cent). The top four categories of conditions were respiratory, musculoskeletal, mental health and episodic and paroxysmal, although the patterns varied amongst the professional groups, and across age groups. Respondents usually managed their main long-term conditions with personal strategies, rarely using workplace strategies.

Research limitations/implications
Although somewhat low, the response rate of 32 per cent was similar to previous surveys in this health service. Since this survey, the health service has implemented a broad Health and Wellness Programme to support their qualified workforce. Future evaluations of this programme will be undertaken, including whether the programme has assisted health professionals to manage their long-term conditions.

Practical implications
There is an urgent need for targeted, workplace-based health promotion strategies to support staff with long-term conditions. Such strategies would complement self-management approaches, and also provide an important recruitment and retention initiative.

Originality/value
This study adds empirical evidence regarding the long-term conditions among health professionals and their self-management strategies. Little is known about the long-term conditions among the various health professional groups and the findings thus make an important contribution to the existing literature.
“I might be shot at!” exploring the drivers to work in hostile environments using an intelligent careers perspective
Authors: Dickmann Michael , Watson Ashley Helen 
Published: October 2017

Purpose
The purpose of this paper is to explore the factors which influence individuals to take up international assignments in hostile environments (HEs). Using an intelligent careers (IC) perspective, an expanded framework of expatriation drivers to work in hostile contexts is developed that comprises individual, organizational and location-specific factors. In addition, the understanding of career capital acquisition and transfer is refined.

Design/methodology/approach
A “deviant” case study method to challenge the underlying assumptions of career capital maximization and transfer in global careers is used. To investigate the case, 25 individuals in an international development organization who had to decide whether to work in HEs were interviewed.

Findings
Five insights into decision drivers and career capital effects associated with postings to HEs are presented. These span all three levels of individual, organizational and location-specific decision factors.

Research limitations/implications
Due to the case study approach, the usual limitations of qualitative case-based research with respect to generalizability apply. In the conclusions three theoretical implications for the IC framework with respect to career capital acquisition, utilization and temporal effects are outlined.

Practical implications
A range of practical implications in relation to the selection, talent management, performance and reward approaches as well as repatriation and family considerations in global mobility are explored.

Social implications
The insights help organizations to design global mobility policies for HEs. In addition, individuals and their families benefit from greater clarity of global mobility drivers in the context of high risks.

Originality/value
The drivers of individuals to accept assignments to HEs are under-researched. This paper operationalizes and applies a holistic decision to work abroad framework, expands the literature on of the motivations of individuals and develops valuable insights to nuance the IC framework.
Regional incidences of adult T‐cell leukemia/lymphoma with cutaneous involvement in Japan
Authors: Hamada Toshihisa , Nomura Hayato , Iwatsuki Keiji 
Published: October 2017

AbstractBetween 2008 and 2015, 462 newly‐diagnosed adult T‐cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). The 391 patients comprised 193 (50%) with smoldering type, 52 (13%) with chronic type, 44 (11%) with lymphoma type and 102 (26%) with acute type. The total number of patients in Kyushu/Okinawa was 8.8‐times higher than that in Kanto, which was set as the reference value, while the estimated prevalence of human T‐lymphotropic virus 1 (HTLV‐1) carriers in Kyushu/Okinawa has been reported to be only 2.5‐times higher than that in Kanto. In this study, the annual incidence of ATLL per 100 000 residents in Kyushu/Okinawa was 32‐times higher than that in Kanto. Our results indicated the higher incidence rate of ATLL in the endemic area than those in the non‐endemic areas in Japan, compared with the regional differences of HTLV‐1 prevalence determined by serological HTLV‐1 screening for blood donors. In addition, this analysis revealed that regional differences of mycosis fungoides/Sézary syndrome incidence rates were very small compared with those of ATLL.
Detection of the mcr‐1 gene in colistin‐resistant Escherichia coli from retail meat in Japan
Authors: Nishino Yukari , Shimojima Yukako , Suzuki Yasunori , Ida Miki , Fukui Rie , Kuroda Sumiyo , Hirai Akihiko , Sadamasu Kenji 
Published: October 2017

ABSTRACTIn this study, the presence of the mcr‐1 gene in Escherichia coli from retail meat in Japan was investigated. Nine E. coli isolates (eight from chickens and one from pork) carried the mcr‐1 gene on the plasmid. In six isolates from domestic chickens, mcr‐1 was located on the IncI2 plasmid, which is approximately 60 kb in size. In the remaining three isolates from imported chicken and pork, mcr‐1 was located on the IncX4 plasmid (30 kb).
Impact of Recent Medicaid Expansions on Office‐Based Primary Care and Specialty Care among the Newly Eligible
Authors: Biener Adam I. , Zuvekas Samuel H. , Hill Steven C. 
Published: October 2017

ObjectiveTo quantify the effect of Medicaid expansions on office‐based care among the newly eligible.Data Source2008–2014 Medical Expenditure Panel Survey.Study DesignThe main sample is adults age 26–64 with incomes ≤138% of poverty who were not eligible for Medicaid prior to the Affordable Care Act. For this population, difference‐in‐differences linear probability models compare utilization between expansion and nonexpansion states and between 2008–2013 and 2014.Extraction MethodsMedicaid eligibility is simulated using data on family relationships, state of residence, and income.Principal FindingsRelative to comparable adults in nonexpansion states, newly eligible adults in expansion states were 9.1 percentage points more likely to have any office‐based primary care physician visit in 2014, a 21.4% increase from 2013 (p‐value = .004); 6.9 percentage points more likely to have a specialist visit, a 25.2% increase from 2013 (p‐value = .036); and 5.1 percentage points more likely to have a visit with a nurse practitioner, nurse, or physician assistant, a 34.5% increase from 2013 (p‐value = .016).ConclusionsState Medicaid expansions in 2014 were associated with greater likelihoods of visits with a variety of office‐based providers. The estimated effects are larger among newly eligible compared with previous estimates on broader populations of low‐income adults.
Dual‐phase hybrid 18F‐Fluoride Positron emission tomography/MRI in ankylosing spondylitis: Investigating the link between MRI bone changes, regional hyperaemia and increased osteoblastic activity
Authors: Sawicki Lino M , Lütje Susanne , Baraliakos Xenofon , Braun Jürgen , Kirchner Julian , Boos Johannes , Heusch Philipp , Ruhlmann Verena , Herrmann Ken , Umutlu Lale , Quick Harald H , Antoch Gerald , Buchbender Christian 
Published: October 2017

AbstractIntroductionFocal 18F‐Fluoride uptake on blood‐pool phase PET represents regional hyperaemia, while it indicates osteoblastic activity on mineralization phase PET. This study investigates the link between regional hyperaemia and osteoblastic activity in inflammatory and chronic lesions of ankylosing spondylitis (AS) of the sacroiliac joints (SIJ) using dual‐phase 18F‐Fluoride PET/MRI.MethodsThirteen patients (six men, seven women, age: 37 ± 10 years) with active AS prospectively underwent dual‐phase 18F‐Fluoride PET/MRI. Blood‐pool phase PET was acquired 6 min and mineralization phase PET 40 min after injection of 158 ± 8 MBq 18F‐Fluoride. SIJ quadrants (SQ) were assessed regarding inflammatory lesions represented by bone marrow oedema (BME), chronic AS lesions such as erosion, fat deposition (FD), sclerosis and ankylosis on MRI, and regarding focal 18F‐Fluoride uptake on both PET datasets. Image quality (IQ) of both PET datasets and MRI was evaluated using a 4‐point Likert scale.ResultsOf 104 SQ, there were 63.4% SQ with FD, 42.3% SQ with BME, 26.9% SQ with erosions, 26% SQ with sclerosis and 10.6% SQ with ankylosis. BME alone was associated with focal 18F‐Fluoride uptake in 63.6% SQ on blood‐pool phase and 90.9% SQ on mineralization phase 18F‐Fluoride PET/MRI. Instead, FD, erosion, sclerosis, ankylosis were not associated with focal 18F‐Fluoride uptake on either blood‐pool or mineralization phase 18F‐Fluoride PET/MRI. SQ showing BME alone or a combination of BME and chronic AS lesions had a significantly higher percentage of focal 18F‐Fluoride uptake on blood‐pool phase and mineralization phase PET/MRI than SQ showing AS lesions without BME (P < 0.001). Both 18F‐Fluoride PET datasets provided high IQ, albeit IQ of mineralization phase PET was superior to blood‐pool phase PET (P < 0.001).ConclusionDual‐phase 18F‐Fluoride PET/MRI of the SIJ showed that inflammatory rather than chronic AS lesions are associated with regional hyperaemia and osteoblastic activity.
Differences in skeletal muscle loss caused by cytotoxic chemotherapy and molecular targeted therapy in patients with advanced non‐small cell lung cancer
Authors: Kakinuma Kazutaka , Tsuruoka Hazime , Morikawa Kei , Furuya Naoki , Inoue Takeo , Miyazawa Teruomi , Mineshita Masamichi 
Published: October 2017

BackgroundRecent studies have revealed a reduction in the skeletal muscle area in patients with advanced non‐small cell lung cancer (NSCLC) after chemotherapy. EGFR and ALK tyrosine kinase inhibitor (TKI)‐based therapies are less cytotoxic than chemotherapy, but differences in skeletal muscle mass between patients receiving EGFR and ALK TKI therapies and patients receiving cytotoxic chemotherapy have not yet been reported.MethodsData of pathologically proven NSCLC patients were reviewed, and chest computed tomography and/or positron emission tomography‐computed tomography images obtained from January 2012 to December 2014 were selected. Patients were divided into two groups: cytotoxic chemotherapy (CG) and molecular targeted (MG). Muscle mass was measured with a single cross‐sectional area of the muscle at the third lumber vertebra (L3MA). To estimate skeletal muscle changes during chemotherapy, we defined the following L3 skeletal muscle index (L3SMI) ratio: post L3SMI/pre L3SMI. Differences in the SMI ratio between the groups were evaluated using the Wilcoxon signed‐rank test.ResultsSixty‐five patients were included in this study: 44 patients received cytotoxic chemotherapy and 21 received molecular targeted therapy (EGFR and ALK TKI). The loss of L3MA in the CG was higher than in the MG (P = 0.03). In the CG, the L3SMI ratio defined to evaluate skeletal muscle mass changes was significantly lower than in the MG (P = 0.0188).ConclusionOur results suggest that skeletal muscle loss during first‐line therapy was significantly different between patients receiving cytotoxic chemotherapy and those receiving TKIs. Specifically, skeletal muscle loss was lower in patients receiving TKIs than in patients receiving cytotoxic chemotherapy.
An efficient method to exploit LiDAR data in animal ecology
Authors: Ciuti Simone , Tripke Henriette , Antkowiak Peter , Gonzalez Ramiro Silveyra , Dormann Carsten F. , Heurich Marco 
Published: October 2017

Abstract

Light detection and ranging (LiDAR) technology provides ecologists with high‐resolution data on three‐dimensional vegetation structure. Large LiDAR datasets challenge predictive ecologists, who commonly simplify point clouds into structural attributes (namely LiDAR‐based metrics such as canopy height), which are used as predictors in ecological models, potentially with loss of relevant information.

We illustrate an efficient alternative approach to reduce the dimensionality of LiDAR data that aims at minimal data filtering with no a priori assumptions on the ecology of the target species. We first fit the ecological model exploiting the full variability in the LiDAR point cloud, then we explain the results using post‐modelling LiDAR‐data classification for ecological interpretation only. This is the classical logic of explorative, hypothesis generating and predictive statistics, rather than testing specific vegetation‐structural hypotheses.

First, we reduce the dimensionality of the LiDAR point cloud by principal component analysis (PCA) to fewer predictors. Second, we show that LiDAR‐PCs are capable to outperforming commonly used environmental predictors in ecological modelling, including LiDAR‐based metrics. We exemplify this by modelling red deer (Cervus elaphus) and roe deer (Capreolus capreolus) resource selection in the Bavarian Forest National Park, Germany. After fitting the ecological model, we provide an interpretation of the information included in LiDAR‐PCs, which allows users to draw conclusions whenever using them as predictors. We make use of the PCA rotation matrix and post‐modelling data classification, and document deer selection for understorey vegetation at unprecedented fine scale.

Our approach is the first attempt in animal ecology to avoid the use of LiDAR‐based metrics as model predictors, but rather generate principal components able to capture most of the LiDAR point cloud variability. Our study demonstrates that LiDAR‐PCs can boost ecological models. We envision a potential use of LiDAR‐PCs in several applications, particularly species distribution and habitat suitability models. We demonstrate an application of our approach by building suitability maps for both deer species, which can be used by practitioners to visualize model spatial predictions and understand the type of forest structures selected by deer.
Wolbachia infection in natural populations of Dictyophara europaea, an alternative vector of grapevine Flavescence dorée phytoplasma: effects and interactions
Authors: Krstić O. , Cvrković T. , Mitrović M. , Radonjić S. , Hrnčić S. , Toševski I. , Jović J. 
Published: October 2017

AbstractThe European lantern fly, Dictyophara europaea, is an alternative vector of the Flavescence dorée phytoplasma (FDp) disease of grapevine in European vineyards, enabling infection initiation from wild reservoir compartment (Clematis vitalba). Heretofore recorded rate of D. europaea FDp‐infection has been very low (3%), making it less epidemiologically significant than would be expected based on reservoir plant infection rate (30%). In this study we present findings on a heavily FDp‐infected D. europaea population (>60%), on the natural Wolbachia infection of populations with low FDp‐infection rates (DeWo+) and on Wolbachia absence in highly FDp‐infected population (DeWo−). We examine several possible causes underlying the differences in vector infection rates: (a) population genetic characteristics of D. europaea and correlation with Wolbachia strain wEur natural infections, (b) Wolbachia effects on fitness components of DeWo+ laboratory colony and (c) rate of reservoir plant FDp‐infection and differences in FDp genotypes harboured by low and highly infected vector populations. The vector genetic diversity level was found to be lower in DeWo+ than in uninfected individuals and to exhibit a different evolution of fixed haplotypes. All DeWo+ populations were infected with the same strain of wEur. The FDp was found to be genetically diversified (five genotypes) but had no relation to infection rates. We did not find evidence of fitness upgrades with regard to Wolbachia infection status. Although more experimentation is needed, it seems that Wolbachia confers protection against FDp or is in competition with FDp according to the observed correlations: low FDp‐infected vector populations are infected with Wolbachia and vice versa.
Increased frequency of retinopathy of prematurity over the last decade and significant regional differences
Authors: Holmström Gerd , Tornqvist Kristina , ‎Al‐Hawasi Abbas , Nilsson Åsa , Wallin Agneta , Hellström Ann 
Published: October 2017

AbstractPurposeRetinopathy of prematurity (ROP) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP is reported.MethodsWith the help of a Swedish register for ROP, SWEDROP, national and regional incidences of ROP and frequencies of treatment were evaluated from 2008 to 2015 (n = 5734), as well as before and after targets of provided oxygen changed from 85–89% to 91–95% in 2014.ResultsRetinopathy of prematurity (ROP) was found in 31.9% (1829/5734) of all infants with a gestational age (GA) of <31 weeks at birth and 5.7% of the infants (329/5734) had been treated for ROP. Analyses of the national data revealed an increased incidence of ROP during the 8‐year study period (p = 0.003), but there was no significant increase in the frequency of treatment. There were significant differences between the seven health regions of Sweden, regarding both incidence of ROP and frequency of treatment (p < 0.001). Comparison of regional data before and after the new oxygen targets revealed a significant increase in treated ROP in one region [OR: 2.24 (CI: 1.11–4.49), p = 0.024] and a borderline increase in one other [OR: 3.08 (CI: 0.99–9.60), p = 0.052].ConclusionThe Swedish national ROP register revealed an increased incidence of ROP during an 8‐year period and significant regional differences regarding the incidence of ROP and frequency of treatment.
A founder mutation in CERKL is a major cause of retinal dystrophy in Finland
Authors: Avela Kristiina , Sankila Eeva‐Marja , Seitsonen Sanna , Kuuluvainen Liina , Barton Stephanie , Gillies Stuart , Aittomäki Kristiina 
Published: October 2017

AbstractPurposeTo study the genetic aetiology of retinal dystrophies (RD) in Finnish patients.MethodsA targeted next‐generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients.ResultsThe overall diagnostic yield was 60% demonstrating the power of this approach. Interestingly, a missense mutation c.375C>G p.(Cys125Trp) in the CERKL gene was found in 18% of the patients in either a homozygous or compound heterozygous state. Data from Exome Aggregation Consortium (ExAC) Browser show that the CERKL c.375C>G p.(Cys125Trp) allele is enriched in the Finnish population and thus is a founder mutation. Furthermore, we report the clinical picture of 18 patients with mutations in the CERKL gene. CERKL mutations cause a macular‐onset disease, in which symptoms first become apparent at the second decade. We also detected other novel founder mutations in the CERKL, EYS, RP1, ABCA4 and GUCY2D genes.ConclusionOur report indicates that the first diagnostic test for Finnish patients with sporadic or autosomal recessive RD should be a targeted test for founder mutations in the CERKL, EYS, RP1, ABCA4 and GUCY2D genes. These results confirm the utility of NGS‐based gene panels as a powerful method for mutation identification in RD, thus enabling improved genetic counselling for these families.