bluuebunny/crossref_metadata_2025_split huggingface dataset:
IKZF1 Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities
Authors: Lopes Bruno A. , Barbosa Thayana C. , Souza Bruna K.S. , Poubel Caroline P. , Pombo-de-Oliveira Maria S. , Emerenciano Mariana 
Published: September 2017

Abstract
SNPs in IKZF1 are associated with inherited susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Besides, somatic copy number abnormalities (CNA) in genes related to lymphopoiesis (e.g., IKZF1, CDKN2A/B, BTG1) impact patient's outcome. Therefore, this study aimed to investigate an association between germline susceptibility and CNAs in BCP-ALL. The IKZF1 SNPs (rs11978267 and rs4132601) were genotyped in 276 cases and 467 controls. Bone marrow samples were used to determine the presence of somatic abnormalities. The IKZF1 transcript levels were quantified and associated with the SNPs and CNAs. Categorical variables were compared by χ2 test. ORs were estimated with unconditional logistic regression with 95% confidence interval (CI). The variant allele of IKZF1 rs4132601 conferred increased risk of BCP-ALL (OR, 2.09; 95% CI, 1.16–3.74). Individuals with either rs11978267 or rs4132601 had an increased risk for harboring IKZF1 deletion (OR, 2.80; 95% CI, 1.25–6.23 and OR, 2.88; 95% CI, 1.24–6.69, respectively). Increased risks were observed for individuals harboring both IKZF1 and BTG1 deletions (OR, 4.90; 95% CI, 1.65–14.55, rs11978267 and OR, 5.80; 95% CI, 1.94–17.41, rs4132601). Germline genetic variation increases the risk for childhood ALL in general, but also acts as a susceptibility factor bound for risk of specific somatic alterations. These findings provide new insight into the development of childhood ALL regarding causal variants and the biological basis of the risk association, offering the opportunity for future tailored research. Cancer Prev Res; 10(12); 738–44. ©2017 AACR.
ЩОДО ПИТАННЯ ГЛОБАЛЬНОГО ТЯГАРЯ ХВОРОБ В УКРАЇНІ
Authors: Dzyuba O. M. , Pazynych L. M. , Sitenko O. R. , Kryvenko Ye. M. 
Published: September 2017

Мета роботи – висвітлити питання глобального тягаря хвороб на підставі вивчення літературних джерел.Матеріали і методи. У дослідженні застосовано бібліосемантичний та аналітичний методи. Розглянуто офіційні нормативні документи та статистичні дані щодо висвітлення проблем глобального тягаря хвороб в Україні.Результати. Основними досягненнями у сфері охорони здоров’я можна вважати: збільшення середньої тривалості життя, подолання багатьох інфекційних хвороб, розвиток профілактичних технологій, появу генної медицини, створення нових поколінь ліків, збільшення частки від ВВП на охорону здоров’я, розвиток сучасних медичних технологій, високий професіоналізм медичного персоналу, підвищення рівня життя в цілому.Висновки. Інвестування в профілактику та більш ефективну боротьбу з неінфекційними захворюваннями дозволить вагомо поліпшити якість життя і підвищити добробут людей і суспільства.
ЛІЖКОВИЙ ФОНД ВІДДІЛЕНЬ СЕРЦЕВО-СУДИННОЇ ТА РЕНТГЕНОЕНДОВАСКУЛЯРНОЇ ХІРУРГІЇ ДЛЯ НАДАННЯ НЕВІДКЛАДНОЇ ДОПОМОГИ ПАЦІЄНТАМ З ІНФАРКТОМ МІОКАРДА В УКРАЇНІ
Authors: Terenda N. O. , Shulhai A. H. 
Published: September 2017

Мета роботи – розрахунок рекомендованої кількості ліжок у відділеннях серцево-судинної та рентгеноендоваскулярної хірургії для проведення СКА з БАП у хворих ІМ.Матеріали і методи. Матеріалом дослідження слугували дані Центру медичної статистики МОЗ України про рівень поширеності ІМ серед населення України та його кількісний склад у 2015 році. У роботі використано епідеміологічний, демографічний, аналітичний, статистичний методи дослідження.Результати. В дослідженні запропоновано адаптовану методику розрахунку рекомендованої кількості ліжок у відділеннях серцево-судинної та рентгеноендоваскулярної хірургії для проведення СКА з БАП у хворих з ІМ залежно від поширеності даної патології та кількісного складу населення. Проведено їх розрахунок для окремих областей та районів України. При розподілі по районах максимальна кількість ліжок необхідна для Південно-Східного району – 30,2 %, Центрального – 21,5 % та Західного – 21,0 % районів.Висновки. Встановлено необхідність включення в багатопрофільні лікарні відділень серцево-судинної та рентгеноендоваскулярної хірургії з рентгеноопераційним блоком для проведення СКА з БАП хворим з ІМ. Рекомендована кількість ліжок для них в Україні становить 205. Запропонована необхідна кількість ліжок по районах дозволить здійснити диференційований підхід у плануванні ліжкового фонду лікувально-профілактичних закладів.
<b>A study on the density, population structure and regeneration of Red Sanders <I>Pterocarpus santalinus</I> (Fabales: Fabaceae) in a protected natural habitat - Sri Lankamalleswara Wildlife Sanctuary, Andhra Pradesh, India</b>
Authors: Ankalaiah Chenchu , Mastan Thondaladinne , Reddy Mullangi Sridhar 
Published: September 2017

Pterocarpus santalinus is a highly valued medium-sized leguminous endemic tree with a restricted range in the southern Eastern Ghats deciduous forests. The enumeration in four 1ha plots has yielded a total of 878 Red Sanders tree individuals (≥30cm girth at breast height - gbh) with a range of 165–246 individuals per ha and 9–51 individuals per 0.01ha. The size class structure revealed that the majority of individuals occurred in lower gbh classes with 364 individuals (39.5%) in 30–50 cm gbh class and 420 individuals (45.6%) in 51–70 cm gbh class, while in the higher gbh class (71–90 cm gbh) only 129 individuals (14%) and seven individuals in >90cm gbh class were recorded. Overall the population structure indicated a low ratio change in lower gbh classes suggesting a stable population. A higher percentage of life stages in recruitment stage like seedlings and saplings than trees was observed and the feature of re-sprouting from roots after fire damage was also recorded. A bottleneck progress from regenerating trees to adult trees was noticed, may be due to slow growth of the species. High stem density and presence of individuals in all the regenerating and reproductive classes suggest that Red Sanders is tolerant to mild disturbance. But the drastic reduction in the density in higher gbh class reflects the concern for recruitment in future as it may affect the seed output due to loss of reproductively fit mature trees.
<b>First record of Rufous-tailed Scrub Robin <I>Cercotrichas galactotes</I> (Aves: Passeriformes: Muscicapidae) from Jammu & Kashmir, India</b>
Authors: Sharma Neeraj 
Published: September 2017

Rufous Tailed Scrub Robin Cercotrichas galactotes a southward passage migrant to India, has an extremely large range in Europe, north and south Africa, central Asia (Kazakhstan and China), middle east to northern Pakistan. Of the five sub-species occurring worldwide, C. g. familiaris, the nominate is a rare fall (September-October) southward migrant to north west India (Punjab, Rajasthan and Gujarat) but has not so far been reported from the state of Jammu and Kashmir and thus a new record for the state.
<b>Spiders of Gujarat: a preliminary checklist</b>
Authors: Yadav Archana , Solanki Reshma , Siliwal Manju , Kumar Dolly 
Published: September 2017

This is a very first attempt to compile a checklist of spiders from Gujarat. It is a result of primary data as well as based on published literature. The spider diversity of Gujarat consists of 415 species under 169 genera and 40 families. Out of these, 29 genera and 17 families are endemic to Gujarat. Overall, high spider diversity was recorded from zone III with 33 families, 132 genera and 278 species. Whereas, the zone with the least spider records was zone VI with only 16 families, 39 genera and 70 species. This is an under estimated number and many new records as well as new species are expected as a result of more systematic studies on spiders in this region.
<b>A second record of the Eastern Spadefoot Toad (Amphibia: Anura: Megophryidae: <I>Leptobrachium bompu</I> Sondhi & Ohler, 2011) with a note on its morphological variations and natural history</b>
Authors: Saikia Bhaskar , Sinha Bikramjit , Kharkongor Ilona J. 
Published: September 2017

A single male specimen of Leptobrachium bompu was collected from Talle Valley Wildlife Sanctuary, Lower Subansiri District, Arunachal Pradesh in 2015. This is the first report of this species after its original description in 2011 based on a male specimen. The present collection locality is about 200km from the type locality. Additional notes on morphological variations have added to the much-needed study on the intra-specific variation of the species.
Magnitude and Characteristics of Patients Who Survived an Acute Myocardial Infarction
Authors: Tisminetzky Mayra , Wang Tracy Y. , Gurwitz Jerry , Kaltenbach Lisa A. , McManus David , Gore Joel , Peterson Eric , Goldberg Robert J. 
Published: September 2017

Background

The purpose of this study was to describe the magnitude and characteristics of patients who did not experience any significant major adverse cardiovascular event early (within 6 weeks) and late (during the first year) after hospital discharge for an acute myocardial infarction (
AMI
).

Methods and Results

Data from 12 243 patients discharged after an
AMI
from 233 sites across the United States in the
TRANSLATE
‐
ACS
(Treatment With
ADP
Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study were analyzed. Multivariable adjusted regression analyses modeled factors associated with 6‐week and 1‐year survivors who did not experience a recurrent
AMI
, stroke, unplanned coronary revascularization, or rehospitalization for unstable angina/chest pain during these time periods. The average age of this study population was 60.0 years, 72.0% were men, and 87.9% were white. In this population, 92.4% were classified as early low‐risk survivors and 76.3% were classified as late low‐risk survivors of an
AMI
. Factors associated with being an early and late postdischarge survivor included being male and having single‐vessel coronary artery disease at the patient's index hospitalization. Patients who were not first seen with any chronic health condition, had an index hospital stay of ≤3 days, and had high baseline quality‐of‐life scores were more likely to be late low‐risk survivors.

Conclusions

Identifying low‐risk survivors of an
AMI
may permit healthcare providers to focus more intensive efforts and interventions on those at higher risk of experiencing adverse cardiovascular events during the postdischarge transition period.

Clinical Trial Registration

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01088503.
Cardiovascular Benefits of Moderate Exercise Training in Marfan Syndrome: Insights From an Animal Model
Authors: Mas‐Stachurska Aleksandra , Siegert Anna‐Maria , Batlle Monsterrat , Gorbenko del Blanco Darya , Meirelles Thayna , Rubies Cira , Bonorino Fabio , Serra‐Peinado Carla , Bijnens Bart , Baudin Julio , Sitges Marta , Mont Lluís , Guasch Eduard , Egea Gustavo 
Published: September 2017

Background
Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long‐term dynamic exercise of moderate intensity on the MF cardiovascular phenotype.

Methods and Results

In a transgenic mouse model of MF (
Fbn1
C1039G/+
), 4‐month‐old wild‐type and MF mice were subjected to training on a treadmill for 5 months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4‐month‐old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5‐month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild‐type group (∆mm, 0.27±0.07 versus 0.13±0.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (∆mm, 0.10±0.04 versus 0.27±0.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis.

Conclusions
Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype.
Diasporic Sociality Online: A Rising ict-dependent Networking Culture and Its Work-life Boundaries (傳播科技與工作/生活界線：離散專業工作者的脈絡)
Authors: Kang (康庭瑜) Tingyu 
Published: September 2017

This research examines the role oficts (Information and Communication Technologies) in blurring work-leisure boundaries among a recent wave of Chinese migrants in Britain, identifying a rising mode ofict-mediated diasporic sociality. In particular, it examines an emergingict-sustained after-work culture that extends their labor process into the leisure setting. Based on in-depth interviews and participant observation, the findings demonstrate how the limited human and social capital Chinese migrants possess encourages them to seek help for work and building client relationships within co-ethnic social ties through leisure events in non-working hours. This type of after-hours labor is discursively constructed as leisure and is characterized by itsict-savvy sociality.本文指出一種由傳播科技中介的新興離散社群社交形式，分析傳播科技如何在新一代的中國移民中模糊他們工作與休閒的界線。透過訪談與參與觀察，本文的研究發現指出中國專業工作者由於其移民的經驗而有較為受限的人力資本和社會資本，這使得他們傾向利用非勞動工時在同族裔的專業工作者之中尋求社會資本。這些下班後的離散社交實踐具有幾種特點，包括：將勞動包裝為休閒並延伸至消費主義式的場景中、傳播科技在這些社交實踐之中的象徵性功能、以及扁平化的資訊傳播結構。 (This article is in English).
Long-distance Filial Piety: Chinese Families in Australasia Caring for Elderly Parents across Borders (長距離的孝道：紐西蘭與澳洲華人家庭的跨國父母照顧)
Authors: Ho (何式怡) Elsie Seckyee , Chiang (姜蘭虹) Lan-hung Nora 
Published: September 2017

In this age of transnational migration, family structures and relationships are transformed as a result of family members living in two or more countries. Over the past three decades, the international migration of Chinese from East Asia to Australia and New Zealand is an example of the global phenomenon of transnationalism, where families employ bi- or multi-local strategies to meet the needs of family members at different stages of their life cycle. Despite this growing trend towards transnationalism, the care of older people in transnational settings has received little attention in studies on migration, transnationalism and care. Older members are in need of help and care when their children and other younger relatives change residence to other countries. In the case of older people who have followed their adult children to live in another country, the need for help and care can arise or increase when the health of the older migrants deteriorates, often making it necessary for other overseas family members to go between countries for the care of their elderly relatives.This paper is based on 80 in-depth interviews with Chinese families in Australia and New Zealand where adult children are providing care to their aged parents living in Taiwan, the People’s Republic of China and Hong Kongsar. The study explores the transnational care-givers’ attitudes towards filial piety, and how filial responsibilities are performed through transnational care-giving. The findings offer insight into the ageing experience of elderly Chinese people in transnational contexts, and stimulates new thinking on broader issues of global human mobility and transnational aged care amongst contemporary Chinese families.隨著全球化與跨國移民的興起，家庭結構與家庭關係因家庭成員分散在不同國家而改變，東亞華人因為移民紐西蘭與澳洲而影響家庭結構並改變家庭關係就是一個例子。過去三十年東亞華人移民到紐西蘭及澳洲的數量大幅增加，家庭成員運用雙方或多方的在地策略，來滿足他們在不同生命階段中的需求；雖然跨國主義普遍發生於各國，但相關長者照顧的研究並未受到重視。當年輕子女離家後，年長父母隨著健康的惡化，生活協助與健康照顧的需求跟著產生，有些父母會隨著子女移往移民國，有些則留在當地由其他親友或移民子女來回奔波照顧。本研究透過深入訪談八十位居住澳洲與紐西蘭的台灣、香港及大陸移民，了解他們如何照顧居住在母國的年長父母。研究探索了跨國照顧者對孝道的看法，以及如何透過跨國照顧來盡孝道。研究結果從跨國移民脈絡中爬梳華人長者的老化經驗，擴展當代全球華人移動議題的討論視野並為跨國長者照顧議題注入新的看法。 (This article is in English).
A Case Series of the Probability Density and Cumulative Distribution of Laryngeal Disease in a Tertiary Care Voice Center
Authors: de la Fuente Jaime , Garrett C. Gaelyn , Ossoff Robert , Vinson Kim , Francis David O. , Gelbard Alexander 
Published: September 2017

Objective: To examine the distribution of clinic and operative pathology in a tertiary care laryngology practice. Methods: Probability density and cumulative distribution analyses (Pareto analysis) was used to rank order laryngeal conditions seen in an outpatient tertiary care laryngology practice and those requiring surgical intervention during a 3-year period. Results: Among 3783 new clinic consultations and 1380 operative procedures, voice disorders were the most common primary diagnostic category seen in clinic (n = 3223), followed by airway (n = 374) and swallowing (n = 186) disorders. Within the voice strata, the most common primary ICD-9 code used was dysphonia (41%), followed by unilateral vocal fold paralysis (UVFP) (9%) and cough (7%). Among new voice patients, 45% were found to have a structural abnormality. The most common surgical indications were laryngotracheal stenosis (37%), followed by recurrent respiratory papillomatosis (18%) and UVFP (17%). Conclusions: Nearly 55% of patients presenting to a tertiary referral laryngology practice did not have an identifiable structural abnormality in the larynx on direct or indirect examination. The distribution of ICD-9 codes requiring surgical intervention was disparate from that seen in clinic. Application of the Pareto principle may improve resource allocation in laryngology, but these initial results require confirmation across multiple institutions.
Comparison of lecture and team-based learning in medical ethics education
Authors: Ozgonul Levent , Alimoglu Mustafa Kemal 
Published: September 2017

Background: Medical education literature suggests that ethics education should be learner-centered and problem-based rather than theory-based. Team-based learning is an appropriate method for this suggestion. However, its effectiveness was not investigated enough in medical ethics education. Research question: Is team-based learning effective in medical ethics education in terms of knowledge retention, in-class learner engagement, and learner reactions? Research design: This was a prospective controlled follow-up study. We changed lecture with team-based learning method to teach four topics in a 2-week medical ethics clerkship, while the remaining topics were taught by lectures. For comparison, we formed team-based learning and lecture groups, in which the students and instructor are the same, but the topics and teaching methodologies are different. We determined in-class learner engagement by direct observation and student satisfaction by feedback forms. Student success for team-based learning and lecture topics in the end-of-clerkship exam and two retention tests performed 1 year and 2 years later were compared. Ethical considerations: Ethical approval for the study was granted by Akdeniz University Board of Ethics on Noninvasive Clinical Human Studies Ethics committee. Findings: Short-term knowledge retention did not differ; however, team-based learning was found superior to lecture at long-term retention tests. Student satisfaction was high with team-based learning and in-class engagement was better in team-based learning sessions. Discussion: Our results on learner engagement and satisfaction with team-based learning were similar to those of previous reports. However, knowledge retention results in our study were contrary to literature. The reason might be the fact that students prepared for the end-of-clerkship pass/fail exam (short term) regardless of the teaching method. But, at long-term retention tests, they did not prepare for the exam and answered the questions just using the knowledge retained in their memories. Conclusion: Our findings suggest that team-based learning is a better alternative to lecture to teach ethics in medical education.
Applying Ecological Frameworks in Obesity Intervention Studies in Hispanic/Latino Youth:
Authors: Kiraly Carmen , Turk Melanie T. , Kalarchian Melissa A. , Shaffer Cheryl 
Published: September 2017

Introduction: In the United States, Hispanic children have higher rates of obesity compared with non-Hispanic White children. An ecological framework provides a holistic view of the environment to which Hispanic/Latino children are exposed that can potentially inform prevention and treatment initiatives for this vulnerable population. Method: This systematic review examines the existing evidence on the use of an ecological framework in intervention studies targeting overweight and obesity in Hispanic youth from birth to 8 years. Key terms guided the search of PubMed, Google Scholar, CINAHL, and EBSCOhost databases from 1997 to 2016. Results were organized using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) method. Results: Seven studies met the inclusion and exclusion criteria. Significant improvements in body mass index z scores in treatment children were evident in five of the seven studies. Increases in fruit, water, and vegetable consumption and physical activity levels were reported in four of the seven studies. Conclusion: Multilevel interventions targeting a child’s home and community suggest efficacy in reducing or preventing obesity; increasing fruit, water, and vegetable consumption; and increasing physical activity in overweight/obese young Hispanic children. Future research is needed to explore the sustainability of multilevel obesity prevention interventions in this vulnerable population.
Value Dominant Logic
Authors: Mahajan Gautam 
Published: September 2017

Value is creating good for, improving the well-being and worth of ourselves and others. Value and value creation are natural to and basic in human behaviour and endeavour, and should be at the centre of our attention. Actors 1 1 Actors are people or institutions. In this article, we will refer to actors as him or himself (which incudes it and itself, them and themselves) for convenience. Actors often interact with other actors. (whether individuals or institutions) in the global ecosystem strive for value for themselves and their constituents. This article proposes a holistic value dominant logic (VDL) that exists universally and encompasses what happens during, before and after (outside) the business and social ecosystem. VDL looks at the needs perspective of the actors and the results of the actors. VDL describes value waiting to happen, how it can be recognized and developed (and its role is creativity and innovation) and how to prevent value destruction. Value, though considered important, has remained a result of the process in service exchange, with no major push on measurements and on conscious value creation. This article aims to put a bigger focus on value and its creation. VDL is based on a global ecosystem; on understanding what value is and how it is embedded in the ecosystem and how it impacts business and society, and beyond. Value addition and value creation are delineated. Eight principles of VDL are enunciated.