bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large‐scale validation and benchmarking of a network of power‐conservative systems using ETSI's Green Abstraction Layer
Authors: Bolla Raffaele , Bruschi Roberto , Davoli Franco , Lago Paolo , Bakay Árpád , Grosso Renato , Kamola Mariusz , Karpowicz Michał , Koch Lavi , Levi David , Parladori Giorgio , Suino Diego 
Published: December 2015

AbstractThe increasing energy demands of networks and networked devices represent a threat to the development of the Future Internet. In this respect, recent research projects were devoted to extending next generation networks, architectures and protocols in the green direction. This paper presents a complex demonstration network specifically designed to assess the viability and the real impact of green networking mechanisms on industrial prototypes. The demonstrator reproduces a complete wire‐line network chain from the core devices to the subscriber terminals, integrating quite a few green mechanisms able to interoperate efficiently and achieve significant reductions in energy consumption. The experimental results and the ensuing impact analysis show how the aggregation of multiple devices with green capabilities can guarantee a satisfactory performance level, while also allowing huge energy savings. Copyright © 2015 John Wiley & Sons, Ltd.
Reorganization of functionally connected brain subnetworks in high‐functioning autism
Authors: Glerean Enrico , Pan Raj K. , Salmi Juha , Kujala Rainer , Lahnakoski Juha M. , Roine Ulrika , Nummenmaa Lauri , Leppämäki Sami , Nieminen‐von Wendt Taina , Tani Pekka , Saramäki Jari , Sams Mikko , Jääskeläinen Iiro P. 
Published: December 2015

AbstractPrevious functional connectivity studies have found both hypo‐ and hyper‐connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high‐functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Twenty‐six subjects (13 with ASD) watched a 68‐min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time‐courses of each pair of 6‐mm isotropic voxels. From the whole‐brain functional networks, we derived individual and group‐level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with ASD) from the ABIDE resting‐state database were included to test the reproducibility of the results. Between‐group differences were observed in the composition of default‐mode and ventro‐temporal‐limbic (VTL) subnetworks. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI‐R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo‐ and hyper‐connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter‐individual similarities that co‐vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro‐temporal and limbic systems in autism. Hum Brain Mapp 37:1066–1079, 2016. © 2015 Wiley Periodicals, Inc.
A novel joint sparse partial correlation method for estimating group functional networks
Authors: Liang Xiaoyun , Connelly Alan , Calamante Fernando 
Published: December 2015

AbstractAdvances in graph theory have provided a powerful tool to characterize brain networks. In particular, functional networks at group‐level have great appeal to gain further insight into complex brain function, and to assess changes across disease conditions. These group networks, however, often have two main limitations. First, they are popularly estimated by directly averaging individual networks that are compromised by confounding variations. Secondly, functional networks have been estimated mainly through Pearson cross‐correlation, without taking into account the influence of other regions. In this study, we propose a sparse group partial correlation method for robust estimation of functional networks based on a joint graphical models approach. To circumvent the issue of choosing the optimal regularization parameters, a stability selection method is employed to extract networks. The proposed method is, therefore, denoted as JGMSS. By applying JGMSS across simulated datasets, the resulting networks show consistently higher accuracy and sensitivity than those estimated using an alternative approach (the elastic‐net regularization with stability selection, ENSS). The robustness of the JGMSS is evidenced by the independence of the estimated networks to choices of the initial set of regularization parameters. The performance of JGMSS in estimating group networks is further demonstrated with in vivo fMRI data (ASL and BOLD), which show that JGMSS can more robustly estimate brain hub regions at group‐level and can better control intersubject variability than it is achieved using ENSS.Hum Brain Mapp 37:1162–1177, 2016. ©2015 Wiley Periodicals, Inc.
‘A Theory of the Allocation of Time’ Turns Fifty: Its Impact on the Field of Health Economics
Authors: Grossman Michael 
Published: December 2015

AbstractThe year 2015 is the 50th anniversary of the publication of ‘A Theory of the Allocation of Time,’ by Gary S. Becker in the 1965 volume of The Economic Journal. To mark that occasion, this editorial focuses on the importance of that paper in the history and evolution of the field of health economics. Copyright © 2015 John Wiley & Sons, Ltd.
Crystal storing histiocytosis clinically mimicking metastatic carcinoma: Report of a case and reviews of literature
Authors: Balakrishna Jayalakshmi , Chen Angela , Urken Mark 
Published: December 2015

AbstractBackgroundCrystal storing histiocytosis (CSH) is a rare disorder characterized by accumulation of histiocytes containing crystalline material inclusions. This entity can be misdiagnosed as infection or tumor. We present a case of idiopathic CSH mimicking metastatic squamous cell carcinoma in a cervical lymph node and review of literature regarding this rare entity.Methods and ResultsThe patient was a 70‐year‐old man with a medical history of squamous cell carcinoma of the right base of the tongue. The patient presented with an enlarged cervical lymph node, which was clinically diagnosed as metastatic carcinoma. At intraoperative consultation, it was unexpectedly discovered that the lymph node exhibited extensive histiocytosis containing crystal materials. Final pathology identified “crystal storing histiocytosis” because of amyloidal depositions. No metastatic carcinoma was seen.ConclusionAfter 10 months of follow‐up, the patient is disease free. To the best of our knowledge, this unusual clinical presentation is the first to describe CSH mimicking a metastatic carcinoma. © 2015 Wiley Periodicals, Inc. Head Neck 38: E95–E98, 2016
Discrimination of skin sensitizers from non‐sensitizers by interleukin‐1α and interleukin‐6 production on cultured human keratinocytes
Authors: Jung Daun , Che Jeong‐Hwan , Lim Kyung‐Min , Chun Young‐Jin , Heo Yong , Seok Seung Hyeok 
Published: December 2015

AbstractIn vitro testing methods for classifying sensitizers could be valuable alternatives to in vivo sensitization testing using animal models, such as the murine local lymph node assay (LLNA) and the guinea pig maximization test (GMT), but there remains a need for in vitro methods that are more accurate and simpler to distinguish skin sensitizers from non‐sensitizers. Thus, the aim of our study was to establish an in vitro assay as a screening tool for detecting skin sensitizers using the human keratinocyte cell line, HaCaT. HaCaT cells were exposed to 16 relevant skin sensitizers and 6 skin non‐sensitizers. The highest dose used was the dose causing 75% cell viability (CV75) that we determined by an MTT [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide] assay. The levels of extracellular production of interleukin‐1α (IL‐1α) and IL‐6 were measured. The sensitivity of IL‐1α was 63%, specificity was 83% and accuracy was 68%. In the case of IL‐6, sensitivity: 69%, specificity: 83% and accuracy: 73%. Thus, this study suggests that measuring extracellular production of pro‐inflammatory cytokines IL‐1α and IL‐6 by human HaCaT cells may potentially classify skin sensitizers from non‐sensitizers. Copyright © 2015 John Wiley & Sons, Ltd.
Synthetic surgical meshes used in abdominal wall surgery: Part II—Biomechanical aspects
Authors: Todros S. , Pavan P.G. , Pachera P. , Natali A.N. 
Published: December 2015

AbstractThis work reports the second part of a review on synthetic surgical meshes used for abdominal hernia repair. While material and structural characteristics, together with mesh–tissue interaction, were considered in a previous article (Part I), biomechanical behavior is described here in more detail. The role of the prosthesis is to strengthen the impaired abdominal wall, mimicking autologous tissue without reducing its compliance. Consequently, mesh mechanical properties play a crucial role in a successful surgical repair. The main available techniques for mechanical testing, such as uniaxial and biaxial tensile testing, ball burst, suture retention strength, and tear resistance testing, are described in depth. Among these methods, the biaxial tensile test is the one that can more faithfully reproduce the physiological loading condition. An outline of the most significant results documented in the literature is reported, showing the variety of data on mesh mechanical properties. Synthetic surgical meshes generally follow a non‐linear stress–strain behavior, with mechanical characteristics dependant on test direction due to mesh anisotropy. Ex‐vivo tests revealed an increased stiffness in mesh explants due to the gradual ingrowth of the host tissue after implant. In general, the absence of standardization in test methods and terminology makes it difficult to compare results from different studies. Numerical models of the abdominal wall interacting with surgical meshes were also discussed representing a potential tool for the selection of suitable prostheses. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 892–903, 2017.
The Excitation Spectra of Naphthalene Dimers: Frenkel and Charge‐transfer Excitons
Authors: Fliegl Heike , You Zhi‐Qiang , Hsu Chao‐Ping , Sundholm Dage 
Published: December 2015

AbstractVertical electronic excitation energies have been calculated at the second‐order approximate coupled‐cluster (CC2) level for a series of dimeric naphthalene systems. The calculated excitation energies are compared with values obtained for a single naphthalene molecule and provide information about the coupling between the naphthalene moieties in the dimers. The calculations show that the coupling between the naphthalenes depends on the distance and the energy of the exciton. At long distances and high energies the excitons on the two naphthalenes are strongly coupled, whereas the excitation energies of the few lowest states are almost unaffected by the presence of the neighboring molecules. We have also analyzed the composition of the dimeric states that consist of the individual monomer states, to investigate the charge‐transfer (CT) and the Frenkel character of the excitons. Our results indicate that the CT exciton exists at short distances, and that its population drops as the distance between the two naphthalene increases.
Free water elimination diffusion tractography: A comparison with conventional and fluid‐attenuated inversion recovery, diffusion tensor imaging acquisitions
Authors: Hoy Andrew R. , Kecskemeti Steven R. , Alexander Andrew L. 
Published: December 2015

PurposeWhite matter tractography reconstructions using conventional diffusion tensor imaging (DTI) near cerebrospinal fluid (CSF) spaces are often adversely affected by CSF partial volume effects (PVEs). This study evaluates the ability of free water elimination (FWE) DTI methods to minimize the PVE of CSF for deterministic tractography applications.Materials and MethodsTen healthy individuals were scanned with "traditional," FLAIR (fluid‐attenuated inversion recovery), and FWE DTI scans. The fornix, corpus callosum, and cingulum bundles were reconstructed using deterministic tractography. The FWE DTI scan was performed twice to separately match total acquisition time (long FWE) and number of measurements (encoding directions, short FWE) to the FLAIR and "traditional" DTI scans. PVE resolution was determined based on reconstructed tract volume. All reconstructions underwent blinded review for anatomical correctness, symmetry, and completeness.ResultsReconstructions of the fornix demonstrated that the FWE and FLAIR scans produce more complete, anatomically plausible reconstructions than "traditional" DTI. Additionally, the tract reconstructions using FWE‐DTI were significantly larger than when FLAIR was used with DTI (P < 0.0005). FLAIR and the FWE methods led to signal‐to‐noise ratio (SNR) reductions of 33% and 11%, respectively, compared with conventional DTI. The long and short FWE acquisitions did not significantly (P ≥ 0.31) differ from one another for any of the reconstructed tracts.ConclusionThe FWE diffusion model overcomes CSF PVE without the time, SNR, and volumetric coverage penalties inherent to FLAIR DTI. J. MAGN. RESON. IMAGING 2015;42:1572–1581.
Can intravoxel incoherent motion diffusion‐weighted imaging characterize the cellular injury and microcirculation alteration in hepatic ischemia‐reperfusion injury? An animal study
Authors: Ye Weitao , Li Jinglei , Guo Chengwei , Chen Shuting , Liu Yu‐bao , Liu Zaiyi , Wu Haijun , Wang Guangyi , Liang Changhong 
Published: December 2015

PurposeTo investigate whether intravoxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) can be used to quantitatively analyze the cellular injury and microcirculation alterations in hepatic ischemia‐reperfusion injury (HIRI).Materials and MethodsThirty‐two New Zealand white rabbits were randomly and equally assigned to the sham group, 1‐hour, 4‐hour, and 12‐hour groups according to the reperfusion time after 1 hour of ischemia using a 70% liver ischemia‐reperfusion injury model. All the animals underwent IVIM‐DWI with 12 b values at 1.5T. The imaging parameters (IVIM parameters and apparent diffusion coefficient [ADC]) among different groups were compared. The correlations between imaging parameters and histological scores, and the ratio of serum aspartate aminotransferase to serum alanine aminotransferase (serum AST/ALT) were analyzed.ResultsDuring the first hour of HIRI, true diffusion coefficient (D) and ADC significantly decreased (P < 0.05), while there was no significant decrease in perfusion fraction (f) (P = 0.708). There was fair to good correlation between histological scores and f (rs = –0.493 with the sham cases excluded, and –0.682 with all cases, both P < 0.05) and ADC (rs = –0.479 with the sham cases excluded, and –0.766 with all cases, both P < 0.05). There was no correlation between imaging parameters and serum AST/ALT with the sham cases excluded (P = 0.673 for f, 0.568 for D, 0.403 for ADC), and good correlation between D, ADC, and serum AST/ALT (r = 0.747 and 0.748, both P < 0.001) with all cases.ConclusionIVIM‐DWI can quantitatively characterize an animal model of HIRI, with D and ADC sensitive in early detection of cellular injury, as well as fair to good correlation between f, ADC, and microcirculation alteration. J. Magn. Reson. Imaging 2016;43:1327–1336.
A parameter extraction method for GaN HEMT empirical large‐signal model including self‐heating and trapping effects
Authors: Wen Zhang , Xu Yuehang , Wang Changsi , Zhao Xiaodong , Chen Zhikai , Xu Ruimin 
Published: December 2015

SummaryThis paper presents an analytical parameter extraction method for empirical large‐signal model of GaN high electron mobility transistors (HEMTs) including self‐heating and trapping effects. Every parameter in the model is extracted in an analytic way. An improved Angelov I–V model specific for GaN HEMTs with 53 parameters is employed. The I–V model parameters are divided into blocks according to their physical meaning, and different blocks are extracted separately by fitting the pulsed I–V transfer characteristic curves of the device at different quiescent bias points. The capacitance model is extracted through mathematical analysis. This method has been implemented in MATLAB (MathWorks, Natick, MA, USA) programming, and good accuracy is obtained between model predictions and experimental results. Copyright © 2015 John Wiley & Sons, Ltd.
YAP and ERK mediated mechanical strain‐induced cell cycle progression through RhoA and cytoskeletal dynamics in rat growth plate chondrocytes
Authors: Yang Kaixiang , Wu Yingxing , Cheng Peng , Zhang Jinming , Yang Chengyuan , Pi Bin , Ye Yaping , You Hongbo , Chen Anmin , Xu Tao , Guo Fengjing , Qi Jun 
Published: December 2015

ABSTRACTYes‐associated protein (YAP) and extracellular signal‐regulated kinase (ERK) have been considered as key regulators in tissue homeostasis, organ development, and tumor formation. However, the roles of YAP and ERK in the mediating strain mechanosensing in the growth plate cartilage have not been determined. In this study, chondrocytes obtained from the growth plate cartilage of 2‐week‐old Sprague–Dawley rats were subjected to the mechanical strain with different magnitudes and durations at a frequency of 0.5 Hz. We found that YAP and ERK activation in response to mechanical strain was time and magnitude dependent. Pretreatment with a RhoA inhibitor (C3 toxin) or a microfilament cytoskeleton disrupting reagent (cytochalasin D) could suppress their activation. In addition, activated YAP and ERK were able to induce cell cycle progression by up‐regulating the expression of cell cycle‐related genes. These results shed new light on the function of YAP and ERK in mechanical strain‐promoted growth plate development. Our results also provided evidence that RhoA and cytoskeletal dynamics are required for this mechanotransduction. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1121–1129, 2016.
Color tuning of indium phosphide quantum dots for cadmium‐free quantum dot light‐emitting devices with high efficiency and color saturation
Authors: Ippen Christian , Greco Tonino , Kim Yohan , Pries Christopher , Kim Jiwan , Oh Min Suk , Han Chul Jong , Wedel Armin 
Published: December 2015

AbstractSemiconductor quantum dots (QDs) promise facile color tuning and high color saturation in quantum‐dot light‐emitting devices (QD‐LEDs) by controlling nanoparticle size and size distribution. Here, we demonstrate how this promise can be practically realized for the cadmium‐free InP/ZnSe/ZnS multishell quantum dots. We developed a set of synthesis conditions and core/shell compositions that result in QDs with green, yellow, and red emission color. The QD‐LEDs employing these QDs show efficient electroluminescence (EL) with luminance up to 1800 cd/m2 and efficiency up to 5.1 cd/A. The color coordinates calculated from the EL spectra clearly demonstrate the outstanding color saturation as an outcome of the narrow particle size distribution. These results prove that the performance gap between cadmium‐free and cadmium‐based QDs in QD‐LEDs is shrinking rapidly.
Orbit fractures: Identifying patient factors indicating high risk for ocular and periocular injury
Authors: Andrews Brian T. , Jackson Anee Sophia , Nazir Niaman , Hromas Alan , Sokol Jason A. , Thurston Todd E. 
Published: December 2015

Objectives/HypothesisMaxillofacial trauma frequently involves the bony orbit that surrounds the ocular globe. Concomitant globe injury is a concern whenever orbit trauma occurs and in severe cases can occasionally result in vision loss. The mechanism of injury, physical exam findings, and radiographic imaging can provide useful information concerning the severity of the injury and concerns for vision loss. Using these three tools, it is hypothesized that the patient's history, physical exam, and radiographic findings can identify high‐risk maxillofacial trauma patients with concomitant ocular injury. Identification of high risk patients who require comprehensive ophthalmologic evaluation may alter management and possibly preserve or restore vision.Study DesignA retrospective clinical chart review was performed at a tertiary academic medical center.MethodsSubjects were identified using the institutional trauma registry. Data collected included subject demographics, patient medical records and notes, ophthalmologic testing, and radiographic imaging. The incidence of orbit fracture and concomitant ocular injury associated with the mechanism of injury, physical exam findings, and radiographic imaging was determined. Statistical analysis was performed using a chi‐square and Fisher exact test.ResultsIn this study, 279 subjects with orbit fractures were identified and the incidence of concomitant ocular injury was 27.6% (77 of 279). Mechanism of injury was statistically associated with an increased risk of ocular injury (P = 0.0340), with penetrating trauma being the most likely etiology. The physical exam findings of visual acuity and an afferent pupillary defect were statistically associated with ocular injury (P = 0.0029 and 0.0001, respectively). Depth of orbit fracture on radiographic imaging was statistically associated with ocular injury (P = 0.0024), with fractures extending to the posterior third of the orbit being most likely to have associated ocular injury.ConclusionMaxillofacial trauma patients with orbit fractures and concomitant ocular injury occur in more than one in four patients. Comprehensive ophthalmologic evaluation is recommended for all patients who sustain an orbit fracture. Subjects with a penetrating trauma mechanism of injury, physical exam findings of visual acuity deficits and an afferent pupillary defect, and radiographic imaging demonstrating fracture depth involvement of the posterior orbit are at highest risk for vision loss and warrant specific concern for ocular injury assessment.Level of EvidenceIV. Laryngoscope, 126:S5–S11, 2016