bluuebunny/crossref_metadata_2025_split huggingface dataset:
FIVE-YEAR OUTCOMES OF INTRAVITREAL INJECTION OF RANIBIZUMAB FOR THE TREATMENT OF MYOPIC CHOROIDAL NEOVASCULARIZATION
Authors: Wu Tsung-Tien , Kung Ya-Hsin 
Published: January 2017

Purpose:
To evaluate the 5-year outcomes, efficacy, and safety of intravitreal ranibizumab injections for the treatment of myopic choroidal neovascularization.

Methods:
The medical records of 18 consecutive eyes of 14 patients who received intravitreal injections of ranibizumab for myopic choroidal neovascularization with a follow-up of 5 years were retrospectively reviewed. Outcomes included best-corrected visual acuity, total number of treatments, and complications.

Results:
The average number of injections over 5 years was 4.56 ± 3.52. Ten eyes (55.56%) had no need for treatment after the first year. Mean best-corrected visual acuity improved from 0.59 ± 0.47 logarithm of the minimum angle of resolution (Snellen equivalent, 6/24) at baseline to 0.32 ± 0.35 logarithm of the minimum angle of resolution (Snellen equivalent, 6/13) at 1 year, and to 0.38 ± 0.42 logarithm of the minimum angle of resolution (Snellen equivalent, 6/15) at 2 years (P = 0.001 and 0.020, respectively; paired t-test). After 2 years, although mean best-corrected visual acuity remained better than baseline, the difference was not statistically significant. At 5 years, vision improved by at least 1 line for 61.11% of eyes and by more than 3 lines for 33.33%. The final visual acuity of 2 eyes was worse than baseline because of disease activity and profound chorioretinal atrophy, which increased in six eyes. No complications were noted.

Conclusion:
Intravitreal ranibizumab was safe and effective for treating myopic choroidal neovascularization. Only 44% of eyes required retreatment after the first year, and vision improved in more than 60% of eyes over 5 years.
BRANCH RETINAL VEIN OCCLUSION SECONDARY TO A RETINAL ARTERIOLAR MACROANEURYSM: A NOVEL MECHANISM SUPPORTED BY MULTIMODAL IMAGING
Authors: Chen Yi , Chen Simon D. M. , Chen Fred K. 
Published: January 2017

Background/Purpose:
To report a case of a branch retinal vein occlusion secondary to a retinal arteriolar macroaneurysm (RAM).

Methods:
Retrospective case report describing examination findings, treatment outcome and unique multimodal imaging features demonstrated on fluorescein angiography, optical coherence tomography, optical coherence tomography angiography and adaptive optics photography of the retinal vessels and RAM.

Results:
A 61-year-old man presented with 20/200 vision in the right eye because of a branch retinal vein occlusion secondary to a RAM. After sector panretinal photocoagulation and a course of 24 intravitreal antivascular endothelial growth factor injections over 4 years, visual acuity improved to 20/25. Fluorescein angiography showed filling of the RAM even after 4 years. Optical coherence tomography angiography demonstrated venous collateral vessels in both the superficial and deep capillary plexuses, and adaptive optics imaging revealed a gap between the RAM wall and occluded vein.

Conclusion:
Multimodal imaging of this unusual presentation illustrated a novel mechanism of branch retinal vein occlusion in which a primary RAM adjacent to the junction of two retinal veins led to obstruction of venous flow without evidence of direct compression. This supports the theory that perianeurysmal microenvironment changes may be of importance in the pathogenesis of venous occlusion.
Noncontact Evaluation of Corneal Grafts: Swept-Source Fourier Domain OCT Versus High-Resolution Scheimpflug Imaging
Authors: Szalai Eszter , Németh Gábor , Hassan Ziad , Módis László 
Published: January 2017

Purpose:
To study the reliability and repeatability of anterior segment measurements in patients who underwent penetrating keratoplasty with swept light source Fourier domain anterior segment optical coherence tomography (SS-OCT) in comparison with a high-resolution Scheimpflug camera.

Methods:
Keratometry (K) and elevation data of the anterior and posterior corneal surfaces, central corneal thickness, and anterior chamber depth were determined in 56 postkeratoplasty eyes (mean age: 59.6 ± 16.5 yrs) with SS-OCT (CASIA SS-1000; Tomey) followed by Scheimpflug photography (Pentacam High Resolution; Oculus). Examinations were also performed on 48 right eyes of 48 age-matched healthy subjects (mean age: 66.3 ± 7.0 yrs).

Results:
A statistically significant difference was detected between both tomographers in anterior flat K [1.7 ± 4.92 diopters (D)], posterior astigmatism (1.32 ± 5.7 D) and elevation (6.65 ± 14.07 μm), and central corneal thickness (27.39 ± 90.81 μm) and anterior chamber depth values (0.14 ± 0.66 mm) in patients who had undergone corneal transplantation (P < 0.05). In the postkeratoplasty group, repeatability of SS-OCT was higher for every anterior segment parameter in comparison with the Pentacam. In corneal grafts, the variability between 3 consecutive measurements on the same subject was remarkably lower for every parameter while using SS-OCT.

Conclusions:
In patients who had undergone corneal transplantation, SS-OCT provided more reliable and repeatable anterior segment evaluations when compared with the rotating Scheimpflug system. Our findings suggested that the tested high-resolution swept-source OCT system is a comprehensive and precise diagnostic tool for postoperative follow-up of patients who have undergone penetrating keratoplasty.
An Unusual Pelvic Mass in a Pediatric Patient: A Case Report and Review of the Pathology
Authors: Bauman Brent D. , Moertel Christopher L. , Zheng Eugene , Louiselle Amanda , Berdan Elizabeth , Berger David , Segura Bradley 
Published: January 2017

Introduction:
Neurofibromatosis type 1 (NF1) is the most commonly inherited autosomal dominant disorder in humans. NF1 patients have increased risk for gastrointestinal stromal tumors (GISTs). A Meckel’s diverticulum (MD) represents a persistent embryonic omphalomesenteric duct characterized as a true diverticulum located near the ileocecal valve. We report a unique clinical case whereby a patient with NF1 developed a GIST within a MD.

Case:
An adolescent male with NF1 presented with persistent lower abdominal pain. Clinical evaluation demonstrated a large pelvic mass. In the operating room, the mass was noted to emerge from a MD. Final pathology demonstrated a GIST with negative margins and CD117 positivity.

Discussion:
Patients with NF1 are at increased risk for mesenchymal tumors including malignant peripheral nerve sheath tumors. GISTs are the most important and frequent non-neurological malignancy in NF1 and develop in ∼7% of NF1 patients. GISTs tend to be multifocal in NF1; however, they rarely occur within a Meckel’s diverticula.

Conclusions:
Our case represents a rare case of a patient with NF1 who developed a symptomatic GIST within a MD. We recommend utilizing laparoscopy to determine resectability and clarify the diagnosis in this unique patient population who are at risk for multiple neoplasms.
Nurse Managers Speak Out About Disruptive Nurse-to-Nurse Relationships
Authors: Moore Linda Weaver , Sublett Cynthia , Leahy Cathy 
Published: January 2017

OBJECTIVE:
The purpose of this study is to explore nurse managers’ (NMs’) perceptions regarding disruptive nurse-to-nurse relationships.

BACKGROUND:
Nurse managers play a pivotal role in creating and sustaining healthy practice environments. They must understand how to recognize and confront disruptive nurse relationships that can threaten the health of their units.

METHODS:
A qualitative study design using researcher-participant interviews of 13 NMs from 5 institutions provided data regarding NMs’ views on nurse relationships.

RESULTS:
Nurse managers reported how they became aware of disruptive nurse relationships, their strategies for dealing with those relationships, and the impact that confronting disruptive relationships had on them personally.

CONCLUSION:
Findings can be helpful to NMs who are faced with addressing disruptive nurse-to-nurse relationships as they endeavor to create and sustain healthy work environments.
Using Public Health Data for Soil Pb Hazard Management in Ohio
Authors: Obrycki John F. , Serafini Tyler , Hood Darryl B. , Alexander Chris , Blais Pam , Basta Nicholas T. 
Published: January 2017

Objectives:
To evaluate how frequently elevated soil lead (Pb) hazards (≥400 ppm Pb) were identified in existing blood Pb site investigations in Ohio.

Design:
This study evaluated 3050 site investigations from the Ohio Department of Health for children with blood Pb levels at or above 10 μg dL−1 that contained bare soil Pb data.

Setting:
Data were collected from existing databases maintained by the Ohio Department of Health.

Participants:
All data were de-identified prior to analysis. The data used included blood Pb level test results for children (18 years or younger) in Ohio, with most data coming from children younger than 6 years.

Main Outcome Measures:
The main outcome measures were blood Pb levels and identified Pb concentrations in environmental media, including soil, paint, and dust.

Methods:
Data were organized and summarized according to county. Summary statistics were generated on the basis of type of environmental media and county.

Results:
Soil samples were collected in approximately 5% of all blood Pb cases in Ohio between 1999 and 2015. Median bare soil Pb was 1030 mg Pb kg−1 (range, 0-345 021 mg Pb kg−1 soil). Fifty-six of Ohio's 88 counties had at least 1 soil sample above 10 000 ppm (mg Pb kg−1). Multiple Pb hazards were identified, including bare soil (74% frequency), deteriorated exterior Pb paint (74%), deteriorated interior Pb paint (72%), and settled Pb dust (72%). Bare soil collected from identified dripline areas contained 2638 ppm Pb above soils collected from bare soil play areas (P = .02). Ninety assessments (3%) contained a bare soil hazard, with no other identified hazards. No trend was found comparing county mean or median Pb with county population. Previously identified high-risk counties for elevated blood Pb levels did not have an elevated prevalence of bare soil Pb hazards compared with other counties (P = .64).

Conclusions:
Site investigators should anticipate finding and managing elevated bare soil Pb in locations throughout Ohio. When communicating with the public about bare soil Pb hazards, practitioners and policy makers should emphasize the importance of addressing all potential Pb exposure sources. Findings demonstrate the importance of the individual home environment for exposure, as previously identified high-risk counties for elevated blood Pb levels were not different from other counties.
Public Health Agency Accreditation Among Rural Local Health Departments: Influencers and Barriers
Authors: Beatty Kate E. , Erwin Paul Campbell , Brownson Ross C. , Meit Michael , Fey James 
Published: January 2017

Objective:
Health department accreditation is a crucial strategy for strengthening public health infrastructure. The purpose of this study was to investigate local health department (LHD) characteristics that are associated with accreditation-seeking behavior. This study sought to ascertain the effects of rurality on the likelihood of seeking accreditation through the Public Health Accreditation Board (PHAB).

Design:
Cross-sectional study using secondary data from the 2013 National Association of County & City Health Officials (NACCHO) National Profile of Local Health Departments Study (Profile Study).

Setting:
United States.

Participants:
LHDs (n = 490) that responded to the 2013 NACCHO Profile Survey.

Main Outcome Measures:
LHDs decision to seek PHAB accreditation.

Results:
Significantly more accreditation-seeking LHDs were located in urban areas (87.0%) than in micropolition (8.9%) or rural areas (4.1%) (P < .001). LHDs residing in urban communities were 16.6 times (95% confidence interval [CI], 5.3-52.3) and micropolitan LHDs were 3.4 times (95% CI, 1.1-11.3) more likely to seek PHAB accreditation than rural LHDs (RLHDs). LHDs that had completed an agency-wide strategic plan were 8.5 times (95% CI, 4.0-17.9), LHDs with a local board of health were 3.3 times (95% CI, 1.5-7.0), and LHDs governed by their state health department were 12.9 times (95% CI, 3.3-50.0) more likely to seek accreditation. The most commonly cited barrier was time and effort required for accreditation application exceeded benefits (73.5%).

Conclusion:
The strongest predictor for seeking PHAB accreditation was serving an urban jurisdiction. Micropolitan LHDs were more likely to seek accreditation than smaller RLHDs, which are typically understaffed and underfunded. Major barriers identified by the RLHDs included fees being too high and the time and effort needed for accreditation exceeded their perceived benefits. RLHDs will need additional financial and technical support to achieve accreditation. Even with additional funds, clear messaging of the benefits of accreditation tailored to RLHDs will be needed.
Two-Dimensional and Three-Dimensional Transperineal Ultrasound Findings in Women With High-Pressure Voiding After Midurethral Sling Placement
Authors: Larson Kindra , Scott Lauren , Cunningham Tina D. , Zhao Yili , Abuhamad Alfred , Takacs Peter 
Published: January 2017

Objectives
The aim of this study was to evaluate dynamic two-dimensional (2D) and 3D transperineal pelvic ultrasound findings with urodynamic studies in women with lower urinary tract symptoms after midurethral sling placement.

Methods
On 2D images, the sling position, and on 3D imaging the sling angle, urethral diameter, urethral height, and urethral cross sectional area were recorded with and without Valsalva. Patients were categorized into 3 groups based on 2D imaging: group 1—at rest, the sling lies parallel to the urethral lumen, and during Valsalva, the sling becomes C shaped; group 2—both at rest and during Valsalva, the sling runs parallel to the urethral lumen; group 3—at rest, the sling is C shaped, and during Valsalva, this curved shape is maintained. For analytical purposes, G3 was compared with G1+2. Multiple logistic regressions were used to evaluate the association between transperineal pelvic ultrasound and urodynamic study.

Results
Univariate analyses to examine the relationships between high-pressure voiding, and each variable revealed that Valsalva sling angle, G3 versus G1+2, and sling position as percentage of the urethral length yielded significant findings (odds ratio, 95% confidence interval, P value for each, respectively: 1.037, 1.001–1.074, 0.04; 11.67, 2.116–64.31, 0.004; and 0.952, 0.911–0.994, 0.02). When including G3 versus G1+2, Valsalva sling angle, and percentage into the regression model, we concluded that there was only statistically significant association between groups and high-pressure voiding (odds ratio, 6.85; 95% confidence interval, 1.12–42.04; P = 0.03).

Conclusions
Transperineal ultrasound can help to predict women with high-pressure voiding after midurethral sling and thus may aid in the diagnosis of partial bladder outlet obstruction.
Biowheel: interactive visualization and exploration of biomedical data
Authors: Hu Chenyue W. , Bisberg Alex J. , Qutub Amina A. 
Published: January 2017

AbstractWe introduce Biowheel (https://biowheel.dibsvis.com/), a web-based award-winning data visualization tool, for exploring high-dimensional and heterogeneous biomedical data. Through interactive sorting and filtering of data, Biowheel enables researchers to quickly detect data outliers, evaluate data consistency, and discover mixed trends. Its interactive data presentation, visually-engaging design, and friendly user interface opens the door to easier, faster and better high-dimensional data interpretation for biomedical professionals with and without programming training.
An Adaptive Geometric Search Algorithm for Macromolecular Scaffold Selection
Authors: Jiang Tian , Renfrew P. Douglas , Drew Kevin , Youngs Noah , Butterfoss Glenn , Shasha Dennis , Bonneau Richard 
Published: January 2017

AbstractA wide variety of protein and peptidomimetic design tasks require matching functional three-dimensional motifs to potential oligomeric scaffolds. Enzyme design, for example, aims to graft active-site patterns typically consisting of 3 to 15 residues onto new protein surfaces. Identifying suitable proteins capable of scaffolding such active-site engraftment requires costly searches to identify protein folds that can provide the correct positioning of side chains to host the desired active site. Other examples of biodesign tasks that require simpler fast exact geometric searches of potential side chain positioning include mimicking binding hotspots, design of metal binding clusters and the design of modular hydrogen binding networks for specificity. In these applications the speed and scaling of geometric search limits downstream design to small patterns. Here we present an adaptive algorithm to searching for side chain take-off angles compatible with an arbitrarily specified functional pattern that enjoys substantive performance improvements over previous methods. We demonstrate this method in both genetically encoded (protein) and synthetic (peptidomimetic) design scenarios. Examples of using this method with the Rosetta framework for protein design are provided but our implementation is compatible with multiple protein design frameworks and is freely available as a set of python scripts (https://github.com/JiangTian/adaptive-geometric-search-for-protein-design).
A conceptual foundation for expectations of corporate responsibility
Authors: Olkkonen Laura 
Published: January 2017

PurposeAbility to identify and meet stakeholder expectations is seen as imperative for succeeding in corporate responsibility (CR). However, the existing literature of CR communication treats expectations predominantly as positive constructions. The purpose of this paper is to address this positivity bias and offer insights for a more profound conceptual and empirical understanding of stakeholder expectations.Design/methodology/approachThe paper presents findings from a targeted literature search and empirical illustrations from a thematic analysis of interview data with a focus on the media sector.FindingsThe conceptual understanding of expectations is advanced by exploring positive (optimistic and hopeful) and negative (cynical and pessimistic) expectations. The empirical examples portray expectation analysis and how it becomes more complex when expectations turn negative.Research limitations/implicationsThe data are limited to one sector but implications are discussed with a wider lens to aid future studies in addressing expectations of CR with less positivity bias and, instead, with more conceptual and empirical precision.Practical implicationsThe identification of different expectation types can help practitioners to map and analyze stakeholder expectations of CR, assess interlinking between positive and negative issues, and address stakeholder criticism in a meaningful way.Social implicationsA more precise understanding of stakeholder expectations has the potential to make organizations more sensitive to their societal context, especially concerning CR as social connectedness.Originality/valueThe paper addresses a gap in current literature concerning the positivity bias of expectations and offers conceptual and empirical tools for future research and practice.
Strategic internal communication of corporate heritage identity in a hypermodal context
Authors: Maier Carmen Daniela , Andersen Mona Agerholm 
Published: January 2017

Purpose
The purpose of this paper is to explore how corporate heritage identity (CHI) implementation strategies are communicated by Grundfos, a 70-year-old global company from Denmark, in their internal history references.

Design/methodology/approach
Drawing on an interdisciplinary methodological framework related to heritage identity communication, hypertextuality, and multi-modality, it proposes a multi-leveled analysis model through which communicative strategies are explored at the level of four semiotic modes (written text, speech, still image, and moving image) and at the level of their hypermodal interplay.

Findings
This exploratory case study explains how CHI implementation strategies are communicated in accordance with the potential and constraints of semiotic modes and hyperlinking affordances. The analytical work suggests that the management employs complex CHI implementation strategies in order to strengthen organizational identity and to influence employees’ identification with the company across past, present, and future.

Research limitations/implications
By examining the semiotic modes’ interconnectivity and functional differentiation in a hypermodal context, this paper expands existing research by extending the multi-modal focus to a hypertextual one.

Originality/value
By exploring CHI implementation strategies from a hypermodal perspective and by providing a replicable model of hypermodal analysis, this paper fills a gap in the heritage identity research. Furthermore, it can also be of value to practitioners who intend to design company webpages that strategically communicate heritage identity implementation strategies in order to engage the employees in the company’s heritage.
A multi-scale extended grey target decision method that considers the value distribution information of grey numbers
Authors: Mao Wenxin , Luo Dang , Sun Huifang 
Published: January 2017

Purpose
The purpose of this paper is to propose a multi-scale extended grey target decision method for dealing with multi-attribute decision-making problems with interval grey numbers whose value distribution information is asymmetrical.

Design/methodology/approach
First, the whitenization weight function (WWF) was adopted to show the value distribution information of interval grey numbers. The definitions of kernel, degree of greyness, relative kernel and whitenization standard deviation of interval grey numbers were given based on the WWF. Then, the relative kernel grey target and whitenization standard deviation grey target were constructed to take full advantage of the owned decision information. Finally, the relative bull’s-eye coefficient was proposed to rank the preference order of all alternatives.

Findings
The relative bull’s-eye coefficient reflects the influence of the decision information on decision results with respect to the mean level and value distribution of attribute values. Thus, the decision-maker could set the return and risk adjustment coefficient according to their preferences and select the optimal alternative with a high expected return and low risk.

Originality/value
The paper considers the valve distribution information of interval grey numbers, and a novel definition for kernels, degrees of greyness, relative kernels and whitenization standard deviations, which are given based on the WWF. The paper not only considers the influence of mean levels of decision information over decision results, but also takes the value distribution information into account.