bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile Synthesis and Electrochemical Evaluation of Coumarin‐Tagged Pyridine and Thiophene Derivatives
Authors: Alharthy Rima D. , Hameed Abdul , Rashida Mariya al‐ , Al‐Moubaraki Aisha , Al‐Mhyawi Saedah R. 
Published: June 2016

AbstractA series of coumarin pyridinethiones and pyridinones has been synthesized employing a range of substituted cyanothioacetamides and cyanoacetamides intermediates. Coumarin pyridinethiones and pyridinones bear different substituents including electron donating groups such as methyl, methoxy dimethylamine in addition to chloro, bromo and nitro as electron withdrawing groups were chosen to study the structure/electrochemical relationship. The influence of electron donating group and electron withdrawing group on different positions of coumarin scaffold was studied utilizing cyclic voltammetry and controlled potential electrolysis at platinum and glassy carbon electrodes. The electrochemical redox mechanisms of synthesized coumarins were proposed and the oxidation and reduction pathways were determined. Data for cyclic voltammetry and controlled potential electrolysis proved that amine center served as the oxidation center, while thiocarbonyl and carbonyl groups were identified as the reduction centers.
A Novel Enzymatic Strategy for the Synthesis of Substituted Tetrahydroisoquinolines
Authors: Bonamore Alessandra , Calisti Lorenzo , Calcaterra Andrea , Ismail Omar H. , Gargano Maurizio , D'Acquarica Ilaria , Botta Bruno , Boffi Alberto , Macone Alberto 
Published: June 2016

AbstractA fully enzymatic asymmetric synthesis of substituted tetrahydroisoquinolines was achieved in two steps starting from dopamine and a set of amine substrates by coupling the activity of a plant diamine oxidase with the recombinant norcoclaurine synthase enzyme from Thalictrum flavum. In the first step, a variety of aliphatic and aromatic amines of general interest as pharmaceutical building blocks were transformed into the corresponding aldehydes by the broad specificity of diamine oxidase enzyme from Lathyrus cicera. In the second step, the stereoselectivity of the norcoclaurine synthase catalyzed reaction to yield (S)‐configured tetrahydroisoquinoline products was exploited by mixing the aldehyde obtained in the first step with dopamine, the committed substrate for the Pictet‐Spengler reaction. The reactions were carried out in aqueous buffer and the products thus obtained were extracted and characterized by chiral GC/MS. Enantiomeric excess > 99% were obtained for all substrates investigated. The method provided a set of novel tetrahydroisoquinolines with potentially interesting pharmacological profiles.
Selective Colorimetric Sensor for the Detection of Hg2+ and H2S in Aqueous Medium and Waste Water Samples
Authors: Kaushik Rahul , Singh Ajeet , Ghosh Amrita , Jose D. Amilan 
Published: June 2016

AbstractDabsyl based new colorimetric sensor 1 for the selective detection of environmentally most important cation Hg2+ and biologically important hydrogen sulfide (H2S) in aqueous medium have been reported. The probe 1 selectively responded to Hg2+ among various cations and shows colour change from yellow to red with the bathochromic shift in Uv‐Vis spectrum via intramolecular charge transfer (ICT) mechanism. The limit of detection for mercury was determined as 80 μM. The possibility of using 1 to detect mercury in industrial waste water samples was also explored with good recovery value. The ensemble 1.Hg2+, also applicable for the detection of H2S (LOD = 28 μM) in water among different bio‐thiols and anions. H2S displaces the mercury from 1.Hg2+ via metal displacement approach and regenerates the original probe 1 within few seconds. Regenerated receptor 1, further used for the detection of mercury ion. Receptor 1 incorporated test paper and polymer based thin films were used as a portable kit for the selective colorimetric detection of mercury and H2S in water.
Thiacalix[4]arene Derivatives Bearing Imidazole Units: A Ditopic Hard/Soft Receptor for Na+ and K+/Ag+ with an Allosteric Effect and a Reusable Extractant for Dichromate Anions
Authors: Zhao Jiang‐Lin , Wu Chong , Zeng Xi , Rahman Shofiur , Georghiou Paris E. , Elsegood Mark R. J. , Warwick Mr. Thomas G. , Redshaw Carl , Teat Simon J. , Yamato Takehiko 
Published: June 2016

AbstractTwo novel receptors 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis[(ethoxycarbonyl)methoxy]‐26,28‐bis‐[1‐methyl‐(imidazole)meth‐oxy]‐2,8,14,20‐tetra‐thiacalix[4]arene (L1) and 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis‐[(benzyl)methoxy]‐26,28‐bis‐[1‐methyl‐(imidazole)‐methoxy]‐2,8,14,20‐tetrathiacalix[4]arene (L2) possessing imidazole moieties based on thiacalix[4]arene in the 1,3‐alternate conformation have been synthesized and characterized. The crystal structures of L1 and L2 have been determined. The binding behaviour towards Li+, Na+, K+ and Ag+ ions has been examined by 1H NMR titration experiments in (CDCl3/CD3CN; 10:1, v/v) solution. The exclusive formation of mononuclear complexes of L1 with metal cations is of particular interest revealing a negative allosteric effect in the thiacalix[4]arene family. Liquid‐liquid extraction experiments indicate that synthesized L2 can be utilized as an efficient reusable extractant for dichromate anion by controlling the pH of the aqueous solution.
Evaluating the Systems Engineering Problem Management Process for Industrial Manufacturing Problems
Authors: Perry Dennis A. , Olson Bill , Blessner Paul , Blackburn Timothy D. 
Published: June 2016

ABSTRACTProblems are ever‐present in nearly all engineered systems. A Systems Engineering Problem Management Process (SEPMP) has been proposed, and this research presents empirical evidence to support its validity. In order to evaluate the SEPMP, which uses a risk management style matrix to monitor problem timeliness and impact, it is necessary to determine the importance of communicating these components of the SEPMP model. A correlation and regression analysis is employed using existing empirical problem data and an analysis including communication of impact and timeliness components as independent variables. The dependent variable is the effectiveness of problem management, modeled as a measurement of the problem timeliness, implemented process improvements, training completed, and process delay as a result of the problem. Communication of timeliness and communication of impact are demonstrated to be significantly predictive of effective problem management. Finally, a plan for continued research is presented, including suggested future analyses to include additional empirical research and case studies of the implementation of a comprehensive problem management process, all of which may encourage acceptance of the SEPMP as a standard systems engineering tool.
Recent Advances in Self‐Oscillating Polymer Material Systems
Authors: Tamate Ryota , Mizutani Akimoto Aya , Yoshida Ryo 
Published: June 2016

AbstractIn 1996, we first reported self‐oscillating polymer gels exhibiting autonomous swelling‐deswelling oscillations driven by the Belousov‐Zhabotinsky reaction. In contrast to conventional stimuli‐responsive gels, the self‐oscillating gel can autonomously and periodically change its volume in a closed solution without any external stimuli. Since the first report, the novel concept of self‐oscillating gels has been expanded into various polymer and gel systems. Herein, we summarize recent advances in self‐oscillating polymers and gels.
Home Automation—A Fast ‐ Expanding Market
Authors: Khedekar Darshan Chandrashekhar , Truco Amelia Carrera , Oteyza Diego A. , Huertas Guillermo Florez 
Published: June 2016

AbstractIn recent years, a host of companies have tried to bridge the technology gap between home automation systems. This collective effort has led to the development of technologies that have triggered the beginning of device interoperability. A seamless ecosystem is being created that aims to improve comfort for dwellers, improve efficiency of homes, and, as an additional result, will create a massive market for home automation devices. Our research revealed that the home automation market has been growing at an enormous pace and additional integration of technologies would continue to stimulate demand even more, further diminishing costs and thereby reducing the exclusivity of the market by bringing them to the masses. © 2016 Wiley Periodicals, Inc.
CRISPR/Cas9 genome editing throws descriptive 3‐D genome folding studies for a loop
Authors: Beagan Jonathan A. , Phillips‐Cremins Jennifer E. 
Published: June 2016

CRISPR/Cas9 genome editing studies have recently shed new light into the causal link between the linear DNA sequence and 3‐D chromatin architecture. Here we describe current models for the folding of genomes into a nested hierarchy of higher‐order structures and discuss new insights into the organizing principles governing genome folding at each length scale. WIREs Syst Biol Med 2016, 8:286–299. doi: 10.1002/wsbm.1338This article is categorized under:

Biological Mechanisms > Cell Fates
Developmental Biology > Developmental Processes in Health and Disease
Laboratory Methods and Technologies > Genetic/Genomic Methods
Bismuth(III) Complexes Based on Bis(triazol) Ligands: Effect of Fluorine Substitution on the Structure and Catalysis for the Polymerization of Glycolide
Authors: Gao Jian , Yuan Yu , Cui Ai‐Jun , Tian Feng , Chen Sheng‐Chun , He Ming‐Yang , Chen Qun 
Published: June 2016

AbstractTwo bismuth(III) complexes {[Bi(btx)0.5Cl4](Hbtx)}n (1) and [Bi2(Fbtx)Cl10](H2Fbtx)2(MeOH) (2) based on the nonfluorinated ligand 1,4‐bis[(1,2,4‐triazole‐1‐yl)methyl] benzene (btx) or the perfluorinated analogue 1,4‐bis[(1,2,4‐triazole‐1‐yl)methyl]‐2,3,5,6‐benzene (Fbtx) were synthesized and characterized. Single‐crystal X‐ray diffraction revealed that 1 is a coordination polymer consisting of an anionic one‐dimensional chain, whereas 2 shows a discrete ionic‐paired structure. Furthermore, 1 was found to be more active than 2 toward the bulk solvent‐free polymerization of glycolide, giving poly(glycolic acid) (PGA) with high molecular weights and moderate molecular weight distributions. The results indicated that the substituent effect plays an important role in controlling the structure and catalytic activity of such complexes.
Assembly of Two Coordination Polymers Based on the Flexible Carboxylate and N‐Donor Ligands with Polycatenane Characterization: Syntheses, Crystal Structures, and Luminescent Properties
Authors: Du Jie , Zou Guanglong , Guo Feng 
Published: June 2016

AbstractThe coordination polymers {[Zn3(bcp)2(bip)(OH)2]·2H2O}n (1) and {[Cd(bcp)(bpa)]·2H2O}n (2) [H2bcp = 1,3‐bis(4‐carboxy‐phenoxy) propane, bmp = 1,4‐bis(2‐methylimidazol‐3‐ium‐1‐yl) biphenyl, and bpa = bis(4‐pyridyl) amine] based on the flexible carboxylate and N‐donor ligands were synthesized and characterized. The structures were determined by single‐crystal X‐ray diffraction analysis and further characterized by elemental analysis, IR spectroscopy, and XPRD. Complex 1 displays a 2D→2D threefold interpenetrated network and complex 2 shows a 1D+1D→2D interpenetrated network. Furthermore, the luminescent properties of complexes 1 and 2 were investigated.
Predispositions to Lymphoma: A Practical Review for Genetic Counselors
Authors: Similuk Morgan , Rao V. Koneti , Churpek Jane , Lenardo Michael 
Published: June 2016

AbstractThis review provides a synopsis for genetic counselors of the major concepts of lymphoma predisposition: genomic instability, immune deficiency, inappropriate lymphoproliferation, and chronic antigen stimulation. We discuss syndromes typifying each of these mechanisms. Importantly, our review of the genetic counseling literature reveals sparse discussion of genetically‐based immune‐mediated lymphoma predisposition, which we address in depth here. We aim to increase awareness among genetic counselors and colleagues in oncology about familial susceptibility and facilitate critical thinking about lymphoma risk assessment. Clinical application of this knowledge is aided by recommendations for collection of personal and family history to guide risk assessment and testing. Lastly, we include a special discussion of genetic counseling issues including perceptions of the context, nature, and magnitude of lymphoma risk, as well as coping with awareness of susceptibility to lymphoma.
Nonsurgical Resolution of a Bucket Handle Meniscal Tear: A Case Report
Authors: Urzen Jessica M. , Fullerton Bradley D. 
Published: June 2016

AbstractA bucket handle meniscal tear (BHMT) often causes intermittent locking of the affected knee as the displaced fragment flips into the intercondylar notch. Surgical correction is usually required. Rare spontaneous healing of BHMTs has been described, primarily in young patients. This case report describes a 43‐year‐old man with magnetic resonance imaging–confirmed medial BHMT who received 3 treatments of platelet‐rich plasma injections in and around the meniscus within 7 months after the diagnosis of the tear. The patient reported resolution of pain with walking 8 months after the injury. Magnetic resonance imaging 10 months after the injury and arthroscopy 47 months after the injury showed complete resolution of the meniscal tear.Level of EvidenceV
Effect of ring size on the side force over ogive-cylinder body at subsonic speed
Authors: Kumar P. , Prasad J.K. 
Published: June 2016

ABSTRACTExperiments and computations have been made to obtain the details of the flow field over a slender body at high angles of attack at a freestream velocity of 17 m/s corresponding to a Reynolds number of 2.9×104based on the base diameter. Experiments indicated that the existence of side force at higher angles of attack is mainly due to the presence of asymmetric vortices in the leeward side. A rectangular cross-section circular ring placed at an axial distance of 3.5 times the base diameter reduced the side force at all the angles of attack. Investigations were made to obtain the effect of the height of the ring at an angle-of-attack of 50° where the side force experienced is relatively large. A ring placed at a distance of 3.5 times the base diameter alters the initial vortices and hence helps in substantial reduction of the side force. Studies with rings of different heights indicate that a ring having a height of 3% of the local diameter reduced the side force at almost all the angles of attack for the present flow conditions and provided the least disturbance to the lift and drag of the body.
Helping Families Cope with the Severe Stress of Dravet Syndrome
Authors: Camfield Peter , Camfield Carol , Nolan Kathleen 
Published: June 2016

AbstractA child with Dravet syndrome shakes family life to the core. Dravet syndrome usually has three phases: (1) up to 1-1½ years: with episodes of febrile status epilepticus but normal development; (2) age 1½ to ~6-10 years: with frequent seizures of varying types, developmental stagnation, behavioural and sleep problems; (3) after ~10 years: improvement in seizures, deteriorating gait, intellectual disability but some developmental gains. Complete seizure control is rare—simply prescribing medication is inadequate to help families. Based on structured interviews with 24 families and confirmed by more informal discussions with other families, we suggest strategies for coping with this catastrophe. A child with Dravet syndrome usually means that one parent cannot work—financial pressures should be anticipated. In Stage 1, the approach to status should include a written protocol. An indwelling catheter for rapid venous access may be helpful. In Stage 2, assistance finding qualified babysitters is required, and the extended family needs encouragement to help. Appropriate equipment, rescue medication and protocols should travel with the child. Siblings may benefit from a system of one parent “on call.” An internet support group provides an invaluable lifeline. In Stage 3, family isolation may be extreme—respite care and personal time for parents are important. Death from status, accidents and SUDEP (sudden unexplained death in epilepsy) occurs in 15%. Fear of SUDEP needs to be addressed. Moving from paediatric to adult care is frightening; an epilepsy transition clinic is useful. Attention to these realities may improve the quality of life for both child and family.
Treatment of Dravet Syndrome
Authors: Wirrell Elaine C. 
Published: June 2016

AbstractDravet syndrome is among the most challenging electroclinical syndromes. There is a high likelihood of recurrentstatus epilepticus; seizures are medically refractory; and patients have multiple co-morbidities, including intellectual disability, behaviour and sleep problems, and crouch gait. Additionally, they are at significant risk of sudden unexplained death. This review will focus predominantly on the prophylactic medical management of seizures, addressing both first-line therapies (valproate and clobazam) as well as second-line (stiripentol, topiramate, ketogenic diet) or later options (levetiracetam, bromides, vagus nerve stimulation). Sodium channel agents—including carbamazepine, oxcarbazepine, phenytoin and lamotrigine—should be avoided, as they typically exacerbate seizures. Several agents in development may show promise, specifically fenfluramine and cannabidiol, but they need further evaluation in randomized, controlled trials. In addition to prophylactic treatment, all patients need home-rescue medication and astatus epilepticusprotocol that can be carried out in their local hospital. Families must be counselled on non-pharmacologic strategies to reduce seizure risk, including avoidance of triggers that commonly induce seizures (including hyperthermia, flashing lights and patterns). In addition to addressing seizures, holistic care for a patient with Dravet syndrome must involve a multidisciplinary team that includes specialists in physical, occupational and speech therapy, neuropsychology, social work and physical medicine.
Misdiagnosed neurosyphilis associated with prolonged psychosis
Authors: Faden Justin , O’Reardon John 
Published: June 2016

ObjectiveAfter the prevalence of syphilis had reached historic lows, the Center for Disease Control devised a plan to eradicate syphilis in the United States. Since that decree there has been a dramatic rise in new cases. Psychosis is an ominous symptom of neurosyphilis.MethodsWe report a case of neurosyphilis that was misdiagnosed and staged incorrectly.ResultsFailure to diagnose neurosyphilis was associated with prolonged psychosis that has been refractory to antipsychotic treatment.ConclusionPsychiatrists should renew their vigilance for neurosyphilis in the setting of a positive screening test and psychosis.
Parasites, politics and public science: the promotion of biological control in Western Australia, 1900–1910
Authors: DEVESON EDWARD 
Published: June 2016

AbstractBiological control of arthropods emerged as a scientific enterprise in the late nineteenth century and the orchard industry of California was an early centre of expertise. In 1900, as the Australian colonies prepared for federation, each had a government entomologist attached to its agriculture department. The hiring of George Compere from California by the Western Australian Department of Agriculture began a controversial chapter in the early history of biological control that was linked to a late, local popularization of acclimatization. Compere became known as the ‘travelling entomologist’ and for a decade brought ‘parasites’ of pest insects from overseas and released them in Perth. His antagonistic disciplinary rhetoric and inflated claims for the ‘parasite theory’ created conflict with his counterparts in the eastern states. The resulting inter-state entomological controversy was played out in the press, revealing the political use of science for institutional and even state identity. It is a story of transnational exchanges, chance discoveries and popular public science: popular because of the promise of a simple, natural solution to agricultural insect pests and because of the public nature of the disputes it generated between the experts. This microcosm contributes to the global historiography of acclimatization, biological control, scientific exposition and the professionalization of agricultural science.
Intra-uterine undernutrition amplifies age-associated glucose intolerance in pigs via altered DNA methylation at muscle GLUT4 promoter
Authors: Wang Jun , Cao Meng , Yang Mei , Lin Yan , Che Lianqiang , Fang Zhengfeng , Xu Shengyu , Feng Bin , Li Jian , Wu De 
Published: June 2016

AbstractThe present study aimed to investigate the effect of maternal malnutrition on offspring glucose tolerance and the epigenetic mechanisms involved. In total, twelve primiparous Landrace×Yorkshire gilts were fed rations providing either 100 % (control (CON)) or 75 % (undernutrition (UN)) nutritional requirements according to the National Research Council recommendations, throughout gestation. Muscle samples of offspring were collected at birth (dpn1), weaning (dpn28) and adulthood (dpn189). Compared with CON pigs, UN pigs showed lower serum glucose concentrations at birth, but showed higher serum glucose and insulin concentrations as well as increased area under the blood glucose curve during intravenous glucose tolerance test at dpn189 (P<0·05). Compared with CON pigs, GLUT-4 gene and protein expressions were decreased at dpn1 and dpn189 in the muscle of UN pigs, which was accompanied by increased methylation at the GLUT4 promoter (P<0·05). These alterations in methylation concurred with increased mRNA levels of DNA methyltransferase (DNMT) 1 at dpn1 and dpn28, DNMT3a at dpn189 and DNMT3b at dpn1 in UN pigs compared with CON pigs (P<0·05). Interestingly, although the average methylation levels at the muscle GLUT4 promoter were decreased at dpn189 compared with dpn1 in pigs exposed to a poor maternal diet (P<0·05), the methylation differences in individual CpG sites were more pronounced with age. Our results indicate that in utero undernutrition persists to silence muscle GLUT4 likely through DNA methylation during the ageing process, which may lead to the amplification of age-associated glucose intolerance.
Canine echinococcosis: the predominance of immature eggs in adult tapeworms of Echinococcus granulosus in stray dogs from Tunisia
Authors: Iraqi W. 
Published: June 2016

AbstractCanine echinococcosis is caused by the adult tapeworm of Echinococcus granulosus. As intermediate hosts, humans and livestock become infected following ingestion of eggs that are passed in the faeces of dogs. Mature eggs develop into hydatid cysts in different organs, leading to hydatid disease, which is a serious public health problem. In the present study, we investigated the proportion of mature eggs of E. granulosus in 140 dogs from three regions of Tunisia. The results showed the predominance of immature E. granulosus eggs in infected dogs and the occurrence of a small proportion of oncospheres. The ability of immature eggs to infect humans and livestock is discussed.