bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyadic effects of attachment styles on marital satisfaction among Chinese couples: The mediating role of perceived partner responsiveness
Authors: Lu Siling , He Ying , Li Qingyin , Chen Ziyuan , Fang Xiaoyi 
Published: September 2024

Insecure attachment styles, widely recognized as negative predictors in most Western samples, have been found to impair marital satisfaction for individuals high in attachment anxiety and attachment avoidance. However, Chinese culture is more tolerant of some features of attachment avoidance, which may lead to different implications of attachment styles for marital relationships. Besides, considering that responses of the partner play a vital role in the interaction of intimate relationships, the current study examined how attachment styles affect marital satisfaction through perceived partner responsiveness (PPR). This study is based on dyadic data from 668 Chinese couples across six marital stages, whose average length of marriage was 15.22 years (ranging from 0.03 to 67.57 years, SD = 13.88). Using the actor-partner interdependence model (APIMeM) to analyze these data, results suggested that: (a) individuals’ attachment anxiety was negatively associated with marital satisfaction for both themselves and their partner, and these associations were partially mediated by PPR; (b) PPR was a full mediator of the positive association between individuals' attachment avoidance and their own marital satisfaction; (c) wives’ PPR fully mediated the positive association between their attachment avoidance and their partner’s marital satisfaction, whereas husbands’ PPR partially mediated the positive association between their attachment avoidance and their partner’s marital satisfaction. These findings differ from previous studies based on Western samples and advance our understanding of how attachment styles are related to PPR and marital satisfaction in Chinese context, providing practical guidance on marital interactions for people with insecure attachment styles.
Beneficial adjunctive effects of the 5HT3 receptor antagonist ondansetron on symptoms, function and cognition in early phase schizophrenia in a double-blind, 2 × 2 factorial design, randomised controlled comparison with simvastatin
Authors: Chaudhry Imran B , Husain Muhammad Omair , Khoso Ameer B , Kiran Tayyeba , Husain Muhammad Ishrat , Qurashi Inti , Rahman Raza Ur , Mehmood Nasir , Drake Richard , Husain Nusrat , Deakin Bill 
Published: September 2024

Background: Variable benefits have been reported from the adjunctive use of simvastatin and the 5HT3 receptor antagonist, ondansetron, in patients with schizophrenia. We investigated their independent efficacy and possible synergy to improve negative symptoms of schizophrenia within a single trial. Methods: A 6-month, randomised, double-blind, placebo-controlled trial with a 4-arm, 2 × 2 factorial design, in three centres in Pakistan. In total, 303 people with stable treated schizophrenia aged 18–65 were randomly allocated to add-on ondansetron, simvastatin, both or neither. The primary outcome was a Positive and Negative Syndrome Scale (PANSS) negative score at 3 and 6 months. Results: Mixed model analysis and analysis of covariance revealed no main effects of simvastatin or ondansetron but a significant negative interaction between them ( p = 0.03); when given alone, both drugs significantly reduced negative symptoms compared to placebo but they were ineffective in combination. Individual treatment effects versus placebo were −1.9 points (95%CIs −3.23, −0.49; p = 0.01) for simvastatin and −1.6 points for ondansetron (95%CIs −3.00, −0.14; p = 0.03). Combined treatment significantly increased depression and side effects. In those with less than the median 5 years of treatment, ondansetron improved all PANSS subscales, global functioning measures and verbal learning and fluency, whereas simvastatin did not. Conclusion: Small improvement in negative symptoms on simvastatin and ondansetron individually are not synergistic in combination in treating negative symptoms of schizophrenia. Ondansetron showed broad efficacy in patients on stable antipsychotic treatment within 5 years of illness. The findings suggest that ondansetron should be evaluated in patients at risk of psychosis or early in treatment.
Class of international functioning disability and health core sets for autism spectrum disorder: Occupational therapists’ perspective
Authors: Üstün Betül , Altuntaş Onur 
Published: September 2024

Purpose: This study was conducted to examine the ICF Core Sets prepared for autism from the perspective of occupational therapists within the scope of the International Classification of Functioning, Disability, and Health. Materials and Methods: Data were collected from 70 occupational therapists working with children diagnosed with autism spectrum disorder. Opinions of the participants were collected using the three-stage Delphi technique. Results: In the first Delphi round in which 70 occupational therapists from our country participated, a total of 2952 concepts related to autism spectrum disorder were named. The collected responses were associated with 142 ICF categories, excluding personal factors, and then the number of categories was reduced to 132 because 10 of them were mentioned by less than 5% of the respondents. While consensus was achieved in 82% of the 111 categories in the comprehensive ICF Core Sets for autism spectrum disorder . Discussion and Conclusion: According to the results of this study, ICF-CSs prepared for autism spectrum disorder overlap with the perspective of occupational therapists to define the physiological, occupational, environmental, and personal factors affecting individuals with autism spectrum disorder . The high level of consensus among occupational therapists underscores the practical applicability and acceptance of ICF Core Sets in the field.
Migraine and brain structure in the elderly: The Rotterdam Study
Authors: Acarsoy Cevdet , Ikram Mohammad Kamran , Ikram Mohammad Arfan , Vernooij Meike W. , Bos Daniel 
Published: September 2024

Background Recent studies suggested that persons with migraine might be at higher risk of structural brain changes, including cerebral small vessel disease and atrophy. However, findings in the literature are inconsistent, with variations observed in the direction, magnitude, and population characteristics of reported effects, and large-scale population-based evidence remains scarce. Hence, we investigated the association of migraine with structural brain changes in a middle-aged and elderly population. Methods Within the population-based Rotterdam Study, lifetime history of migraine was assessed using a validated questionnaire between 2006 and 2011. Magnetic resonance imaging of the brain was performed in 4920 participants (median age 61.7 [IQR 45.5, 97.5] years, 55.4% female) to assess imaging markers of cerebral small vessel disease and brain atrophy. We used linear and logistic regression models to examine the cross-sectional association of migraine with brain volumes (total grey and white matter volumes in mL) and cerebral small vessel disease markers (white matter hyperintensity volume in mL, presence of lacunes and cerebral microbleeds). Adjustments were made for age, sex, intracranial volume and cardiovascular variables. Analyses were also stratified by sex and presence of aura. Results The lifetime prevalence of migraine was 15.3% (752/4920). In multivariable adjusted regression models, we found no statistically significant differences between participants with and without migraine in terms of total brain volume (mean difference [MD]: 2.21 mL, 95% confidence interval [CI]: −0.38 ; 4.81), grey matter volume (MD: 0.38 mL, 95% CI: −1.98 ; 2.74), white matter volume (MD: 2.19 mL, 95% CI: −0.56 ; 4.93), log white matter hyperintensity volume (MD: −0.04 mL, 95% CI: −0.10 ; 0.02), presence of lacunes (odds ratio [OR]: 0.82, 95% CI: 0.58–1.15), and presence of cerebral microbleeds (OR: 0.95, 95% CI: 0.76–1.18). Conclusion In this study, we found that middle-aged and elderly participants with migraine were not more likely to have structural brain changes on magnetic resonance imaging.
Analysis of the impact of exfoliated graphene oxide on the mechanical performance and in-plane fracture resistance of epoxy-based nanocomposite
Authors: Singh Sandeep Kumar , Singh Thingujam Jackson , Nayak Biswajeet , Sonker Puneet Kumar , Singh Meinam Annebushan 
Published: September 2024

Graphene oxide (GO) is a versatile material, derivative of graphene, and it has gained significant attention in the field of polymer nanocomposites due to its exceptional properties and unique structural features. These characteristics make it a successful secondary reinforcing agent for enhancing mechanical performance, fatigue resistance, and other various physical and thermal properties of nanocomposites. However, the low fracture toughness of nanocomposite has restricted the overall structural applications. In this research work, the epoxy nanocomposites were prepared with different weights of exfoliated graphene oxide (E-GO) nanoparticles by using a dual mixing probe ultra-sonication for homogeneous distribution and proper dispersion. A substantial enhancement in mechanical performance and fracture toughness of nanocomposite was observed. The good dispersion and interfacial adhesion among E-GO and epoxy matrix were investigated through the critical analysis of the fracture surfaces of the nanocomposite. The enhancement of mechanical performance of E-GO nanofiller-reinforced epoxy composite was observed superior at 1 wt. % of GO60 particle concentration. The maximum increment of mechanical properties such as tensile strength, flexural strength, and work of fracture were 40.763, 39.23, and 12.106 % respectively, whereas maximum tensile modulus and flexural modulus were 19.3724, 27.63 % at 1.5 wt. % of GO60 as compared to the neat composite. However, in the case of fracture toughness and energy, maximum improvement of 1.256 Mpa.m1/2 and 0.472 KJ/m2 respectively was observed at 1 wt. % of GO60. Such enhancement was primarily due to the bolstering of in-plane crack propagation resistance in the nanocomposites. Additionally, the highlight point in thermomechanical properties of the polymer nanocomposite is optimal storage modulus and damping factor such as 4066.75 MPa, and 0.46 respectively, for the GO60 at 1 wt.% nanocomposite. Moreover, GO60 at 1 wt.% demonstrates greater thermal stability, withstanding up to 50% material degradation at 413.65°C.
Inhibitory Effect of Cayratia albifolia C. L. Li Extract on LPS-induced Inflammation of RAW264.7 Cells by Regulating the Nrf2/HO-1 Axis
Authors: Tan Yi , Cao Liang , Zhou Dan , Qin Biao , Zhang Yanbin , Liu Jianxin , He Kai , Li Bin , Zhang Zaiqi 
Published: September 2024

Background Cayratia albifolia C. L. Li (Jiao Mei Gu (JMG)) has potential therapeutic effects in inflammatory diseases. Objectives The primary goal of the research was to focus on the antioxidant and anti-inflammatory qualities of C. albifolia and the underlying mechanisms that contribute to these benefits. Materials and Methods To explore the anti-inflammatory abilities of JMG, we employed enzyme-linked immunosorbent assay and nitric oxide (NO) assay in a lipopolysaccharide (LPS)-induced macrophage inflammation model. Furthermore, flow cytometry was employed to assess the antioxidant effects of C. albifolia, and Western blotting was used to reveal the underlying mechanisms. Results Ethyl acetate extract of C. albifolia effectively reduced the release of NO, interleukin-6, tumor necrosis factor-α, and prostaglandin E2 in macrophages. Additionally, it prevented the expression of reactive oxygen species. Mechanistically, the extract may downregulate the expression of inducible nitric oxide synthase, cyclooxygenase-2, the nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) protein expression. Conclusion The ethyl acetate extract of C. albifolia demonstrated remarkable anti-inflammatory and antioxidant effects by modulating the Nrf2/HO-1 axis.
Response to workplace aggression in forensic and secure mental health services: Investigating staff confidence, associated factors, and training needs
Authors: He Wei , Denman Lara , Luder Michael , Stedman Terry 
Published: September 2024

Objective To evaluate forensic and secure mental health services (FSMHS) staff’s confidence in managing workplace aggression, identify associated factors, and explore their workplace aggression prevention training needs. Methods Through an online survey, staff rated their experience of workplace aggression, perceived effectiveness of current training, and confidence in responding to workplace aggression, and described training needs. Stepwise multiple regression was used to identify associated factors with statistical significance. Thematic analysis was used to generate themes describing their training needs. Results The staff perceived current training as low-to-medium in effectiveness, mirroring their confidence in managing workplace aggression. Nurses experienced more workplace aggression compared to other professions. Staff working at High Security perceived current training as less effective compared to those working at Medium Security or Low Security. Qualitative findings underscored the necessity for improved training content, methods, and supportive strategies. Conclusion Recommendations for enhancing training include: tailoring training to FSMHS settings; equally focussing on both non-physical and physical intervention techniques; providing more scenario-based hands-on practice opportunities; delivering training in a reasonable trainer-trainee ratio; prioritising nurses and High Security staff and integrating other professions into the training framework; and implementing strategies that support staff, consumers, and environment to ensure training effectiveness and applicability.
Impact of Facility Volume on Overall Survival in Patients With Head and Neck Cancer Undergoing Palliative Treatment
Authors: Kaki Praneet C. , Patel Aman M. , Revercomb Lucy , Maxwell Russell , Brant Jason A. , Brody Robert M. , Cannady Steven B. , Carey Ryan M. 
Published: September 2024

Background Treatment at high-volume facilities (HVF) has been associated with improved prognosis of HNC patients undergoing curative treatment. Whether this systemic factor influences survival outcomes of patients with HNC undergoing palliative treatment is unknown. Aim To investigate the impact of palliative treatment facility volume on overall survival (OS) in patients with head and neck cancer (HNC). Design The 2004 to 2018 National Cancer Database was queried retrospectively for patients with HNC undergoing palliative treatment. Setting/participants Patients were stratified based on treatment facility volume percentile. Multivariable binary logistic and Cox proportional hazards regression models were implemented. Results Of 8682 patients included, 1661 (19.1%) underwent palliative therapy at facilities with volume ≥80th percentile. Among 972 facilities included, 643 (66.2%), 182 (18.7%), 85 (8.8%), 44 (4.5%), and 18 (1.9%) had volume <20th, 20-40th, 40-60th, 60-80th, and ≥80th percentiles, respectively. 5-year OS rates of patients undergoing palliative therapy at facilities with volume <20th, 20-40th, 40-60th, 60-80th, and ≥80th percentile was 11%, 13%, 11%, 14%, and 23%, respectively ( P < .001). Facility volume ≥80th percentile was associated with higher 5-year OS on multivariable Cox regression (aHR 0.34, 95% CI 0.16-0.69, P < .001). Surgical treatment (aOR 1.34, 95% CI 1.07-1.68, P = .012) was associated with undergoing treatment at facilities with volume ≥80th percentile. Conclusions Undergoing palliative treatment at HVFs is associated with higher OS in HNC. The survival benefit derived from high facility volume should be carefully considered in the context of other patient and facility characteristics in end-of-life management, with specific emphasis on patient-directed goals of care.
Catheter and Non-Catheter-Related Venous Thromboembolism in Cancer Patients: Survival, Anticoagulation Efficacy, and Safety
Authors: Liang Feng , Chao Min , Song Kai-Yi , Wang Hui-Qi , Jiang Ling-Zhi , Ye Xiang-Ming 
Published: September 2024

Purpose To investigate the differences in survival after venous thromboembolism (VTE) and anticoagulation efficacy and safety between catheter (CRVTE) and non-catheter-related VTE (NCRVTE) in cancer patients. Methods A retrospective research was conducted, and consecutive cancer (digestive, respiratory, genitourinary, blood and lymphatic, and the other cancers) patients with VTE were enrolled. The anticoagulation therapies included low-molecular-weight heparin (LMWH), warfarin, new type of direct oral anticoagulants (NDOACs), LMWH combined with warfarin, and LMWH combined with NDOACs. Data were collected from the electronic medical record database of our hospital and were analyzed accordingly by Kruskal-Wallis H Test, Chi-square test, Fisher's exact test, Logistic regressions, Kaplan-Meier analysis, and Cox regressions. Results 263 patients were included, median age in years (interquartile range) was 64(56-71) and 60.5% were male. VTE recurrence rate was 16.7% in CRVTE group which was significantly lower than 34.8% in NCRVTE group ( P = .032). Heart diseases were independently associated with VTE recurrence ( P = .025). Kaplan-Meier survival estimates at 1, 2, and 3 years for CRVTE group were 62.5%, 60.0%, and 47.5%, respectively, compared with 47.9% ( P = .130), 38.7% ( P = .028), and 30.1% ( P = .046), respectively, for NCRVTE group. Cox regression showed surgery ( P = .003), anticoagulation therapy types ( P = .009), VTE types ( P = .006) and cancer types ( P = .039) were independent prognostic factors for 3-year survival after VTE. Nonmajor and major bleeding were not significantly different ( P = .417). Anticoagulation therapy types were independently associated with the bleeding events ( P = .030). Conclusions Cancer patients with CRVTE potentially have a better anticoagulation efficacy and survival compared to NCRVTE, and the anticoagulation safety seems no significant difference.
Assessment of chemotherapy-related adverse drug reactions among multiple myeloma patients at Kenyatta national hospital
Authors: Assenga Epifania Amedeus , Degu Amsalu , Omolo Calvin A 
Published: September 2024

Background Despite treatment modalities for multiple myeloma can cause adverse drug reactions (ADRs), data are scarce about the types, severity and preventability of chemotherapy-related ADRs in Kenya. This study aimed to assess the chemotherapy-related ADRs among multiple myeloma patients at Kenyatta National Hospital (KNH). Methods A one-arm retrospective cohort study was carried out among all eligible adult patients with a documented diagnosis of multiple myeloma between 1st January 2017 to 31st December 2023. A data abstraction tool was used to assess sociodemographics, clinical characteristics and chemotherapy-related ADRs. The Schumock and Thornton scale and the modified Hartwig and Siegel severity scale were employed to evaluate the preventability and severity of ADRs, respectively. Data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 29.0 software. The results were presented using mean, frequency and percentage. Binary logistic regression was employed to assess factors influencing ADRs. A p-value of less than 0.05 was considered statistically significant. Results The prevalence of ADRs in this study was 81.5% with a total of 230 ADRs identified. The primary ADRs identified were peripheral neuropathy (21.7%), nausea and vomiting (14.8%), neutropenia (12.2%) and anemia (11.3%). The majority of the ADRs (51.7%) were moderate in severity, and 29.8% were of mild severity. Preventability assessments of the ADRs showed that most of them (68.2%) were definitely preventable and 13.2% were probably preventable. VRD (Bortezomib/Lenalidomide/Dexamethasone) and VCD (Bortezomib/Cyclophosphamide/Dexamethasone) treatment regimens were responsible for most of the ADRs. VRD (AOR = 11.1, 95% CI = 3.7–32.8, p < 0.001) and VCD treatment regimens (AOR = 4.8, 95% CI = 1.1–20.0, p = 0.033) were the significant factors affecting the occurrence of ADRs. Conclusion Overall, the incidence of chemotherapy-related ADRs in multiple myeloma patients at KNH was notably high (81.5%). Despite the moderate severity of the ADRs, their preventable nature highlights the potential for improved patient outcomes through careful regimen selection and monitoring.
Sisters, Bottoms, and “Exotic Combo”: Homonormative Misogyny and Respectable Masculinity of Middle-Class Gay Sex Workers in Hong Kong
Authors: Tsoi David Kwok Kwan 
Published: September 2024

This article brings together queer studies and masculinities studies to discuss how middle-class gay sex workers in Hong Kong manage the stigma of same-sex sex work. Based on 11 months of ethnographic fieldwork in a gay erotic massage parlor in Hong Kong, I examine how middle-class gay sex workers in Hong Kong deploy locally specific notions about gender, class, and border to mitigate their anxiety about sex work and to establish a form of gay masculinity. The middle-class gay masseurs claim a respectable self through narrating multiple disrespectable others—women streetwalker, bottom masseur, and lower-class migrant sex worker. In everyday banter, satire, and bawdy jokes around these three figures, masseurs invoke homonormativity through misogynistic discourses about migrant women, femininity, effeminacy, and penetration. In so doing, they simultaneously produce gay masculinity and gay misogyny, a process I term “homonormative misogyny.” In neoliberal Hong Kong, this form of gay respectability politics is emergent in an increasingly gentrified sexual economy.
Predictors of incident stroke among individuals without coronary artery calcification: A pooled cohort analysis from the Multi-Ethnic Study of Atherosclerosis, Jackson Heart Study, and Framingham Heart Study
Authors: Hussain Aliza , Johansen Michelle C , Blaha Michael J , Al-Mallah Mouaz H , Cainzos-Achirica Miguel , Nambi Vijay , Rotter Jerome I , Guo Xiuqing , Yao Jie , Rich Stephen S , Patel Jaideep , McEvoy John W , Nasir Khurram , Gottesman Rebecca , Blumenthal Roger S , Ballantyne Christie M , Virani Salim S , Al Rifai Mahmoud 
Published: September 2024

Introduction: The absence of coronary artery calcium (CAC = 0) is associated with low risk of stroke events; however, predictors of incident stroke among those with CAC = 0 are not known. Methods: Individual participant-level data were pooled from three prospective cohorts (Multi-Ethnic Study of Atherosclerosis [MESA], Jackson Heart Study, and Framingham Heart Study). Multivariable-adjusted Cox proportional hazards models were used to study the association between cardiovascular risk factors and incident adjudicated stroke among individuals with CAC = 0 who were free of clinical atherosclerotic cardiovascular disease at baseline. Results: Among 6180 participants (mean age 53 [SD 11] years, 62% women, and 44% White, 36% Black, and 20% other individuals), over a median (IQR) follow up of 15 (12–16) years, there were 122 strokes (95 ischemic, 27 hemorrhagic) with an overall unadjusted event rate of 2.0 per 1000 person-years. After multivariable adjustment, risk factors associated with overall stroke included (hazard ratio [95% CI]) systolic blood pressure (SBP): 1.19 (1.05–1.36) per 10-mmHg increase and carotid intima–media thickness (CIMT): 1.21 (1.04–1.42) per 0.1-mm increment. Current cigarette smoking: 2.68 (1.11–6.50), SBP: 1.23 (1.06–1.42) per 10-mmHg increase, and CIMT: 1.25 (1.04–1.49) per 0.1-mm increment were associated with ischemic stroke, whereas C-reactive protein was associated with hemorrhagic stroke risk (0.49, 0.25–0.93). Conclusion: In a large cohort of individuals with CAC = 0, the rate for incident stroke was low (2.0 per 1000-person years) and was associated with modifiable risk factors.