bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ankle Subluxation and Associated Ruptures: A Case Report on Surgical Intervention in a 47- year-old Male Badminton Military Athlete
Authors: Rezha Danny M , Indrayana Sagitha 
Published: October 2024

Introduction & Objectives: This study presents the clinical approach and surgical management of a 47-year-old male patient without prior medical history or comorbidities, who experienced acute ankle pain following a distinctive "klek" sound during badminton activity. The objective is to demonstrate the significance of accurate diagnosis and appropriate surgical intervention for such injuries. Materials & Methods: A comprehensive patient history was taken, coupled with a physical examination and diagnostic imaging, which identified the primary complaint of ankle pain. The subsequent diagnosis was an ankle subluxation, intraosseous rupture of the tibia fibula, and rupture of the Achilles tendon. Intervention consisted of an open reduction of the ankle and Achilles tendon repair, performed under regional anesthesia. Results: The surgical procedure was executed successfully with no immediate post-operative complications. The patient's post-surgical recovery was thoroughly monitored, and rehabilitation began promptly to regain full function and mobility. Conclusion: This case underscores the importance of a precise diagnosis in orthopedic injuries and the need for tailored surgical procedures to effectively address them. Open reduction and Achilles repair were pivotal in treating the ankle subluxation and related ruptures. Such cases augment the understanding of orthopedic surgical techniques for specialized injuries, emphasizing patient-specific diagnosis and management.
Comparison of Arthroscopy-Assisted Reduction Internal Fixation versus Open Reduction Internal of Tibial Plateau Fracture Management: A Systematic Review of Case Control Studies
Authors: Mahardika Yudi , Wien Aryana I Gusti Ngurah 
Published: October 2024

Background: Tibial plateau fractures are complex injuries that demand meticulous surgical techniques to achieve anatomical reduction and stable fixation. Both ARIF and ORIF have been utilized for fracture management, each with its advantages and limitations. ARIF offers the potential for enhanced visualization, accurate reduction, and minimally invasive approaches. This review aims to assess the available evidence to determine whether ARIF offers superior outcomes compared to ORIF in tibial plateau fracture management. Method: A systematic search of relevant databases was conducted to identify case control studies comparing ARIF and ORIF for tibial plateau fractures. Inclusion criteria encompassed studies reporting KSS as an outcome measure. Quality assessment and data extraction were performed independently by two reviewers. Result: The systematic review identified a total of four case-control studies meeting the inclusion criteria with total of 261 patients with tibial plateau fractures. The sample sizes varied across the studies, with the smallest study including 40 patients and the largest study including 317 patients. The outcomes were assessed using various scoring systems, including IKDC scores, Lysholm scores, and KSS scores. The results consistently showed that ARIF had higher scores compared to ORIF, indicating better functional outcomes. Conclusion: ARIF holds promise as a superior technique compared to ORIF for managing tibial plateau fractures. ARIF offers enhanced visualization, more accurate reduction, and potentially faster postoperative recovery. However, individual patient and fracture characteristics must still be considered when determining the optimal surgical approach. Further high-quality prospective studies and long-term follow-up are warranted to confirm these findings and establish the broader applicability of ARIF in diverse tibial plateau fracture scenarios.
Patellar-shaped Osteochondromatosis in Young Adults: A Rare Case
Authors: Christian Dachi Felix Norman , Utoyo Ghuna Arioharjo , Budi Irawan M. Naseh Sajadi 
Published: October 2024

Introduction: Synovial chondromatosis is a rare, benign condition that affects the synovial lining of joints, bursae, and synovial sheaths. It commonly occurs in larger joints and presents as a metaplastic disorder affecting a single joint. This case report focuses on an unusual occurrence of synovial chondromatosis in young adults, specifically with a patellar-shaped presentation. Case Presentation: A 23-year-old male patient presented with a two-year history of right knee pain and the presence of a gradually enlarging lump. The lump, currently the size of a pingpong ball, has limited the patient's range of motion in his knee joint. An MRI scan revealed a solid mass in the hoffa's fat pad on the right knee joint suggestive of extraskeletal ossifying chondroma, as well as minimal fluid accumulation in the knee joint. The mass located in front of anterior meniscus and posterior of patellar tendon, it makes the pattelar tendon redundant and patellar alta (Insall-Salvati ratio 0.88), so we performed wide excision patellar tendon augmentation with tape (ultra high molecular weight polyethylene based) and imbrication of MPFL. Histopathological analysis confirmed osteochondromatosis measuring 6.5x5x3.5cm, resembling the shape of a patella. Post-operation x-ray examination showed no signs of ossification in the hoffa's fat area or any narrowing or sclerosis in knee joints. Furthermore, there were no visible fracture/dislocation lines or indications for osteomyelitis. The patient is now free from pain and can move without any limitations in range of motion. Discussion: Synovial Chondromatosis with pattelar-like shape mass is uncommon benign tumor that rarely affects young adults. Effective surgical treatments such as wide excision and patellar tendon augmentation using UHMWPE tape with imbrication of the medial patellofemoral ligament have demonstrated favorable outcomes for cases of osteochondromatosis that have reached a significant size and are impacting adjacent tendons.
Haglund’s Deformity, Retrocalcaneal Bursitis, and Achilles Tendinopathy (Haglund’s Syndrome) Treated with Arthroscopic Calcaneoplasty, Synovectomy and PRP Injection Outcome Score: A Case Report
Authors: Haryono Handy , Lim Evan 
Published: October 2024

Introduction: Haglund’s deformity is an abnormal bony enlargement of posterosuperior part of calcaneus at the attachment of achilles tendon which often leads to retrocalcaneal bursitis and insertional achilles tendinopathy (Haglund’s syndrome) causing back heel pain. Arthroscopic calcaneoplasty, synovectomy and PRP injection should be considered as minimally invasive treatment option with speedy recovery. Case Report: A 57 years old woman came with pain and lump at posterior site of left ankle more than right ankle since 6 months before that didn’t respond conservatively. Pain was felt with pressure on left ankle with edema. AOFAS Ankle-Hindfoot score was 65%. X-Ray and MRI showed Haglund’s deformity with achilles tendon impingement. The patient was diagnosed with Haglund’s deformity, retrocalcaneal bursitis and achilles tendinopathy. Arthroscopic calcaneoplasty, synovectomy and PRP injection was then conducted. One week after operation, pain decreased and she could do daily activities better with AOFAS Ankle-Hindfoot score increased to 87%. Two weeks after operation, pain was still felt but seldom with AOFAS Ankle-Hindfoot score remain at 87%. Result and Discussion: Haglund’s syndrome is mostly idiopathic with several factors suggested. Clinical features are back heel pain, swelling, bump on posterior heel and inflammation signs. Dorsiflexion causes pain of the ankle. Lateral radiographic can show bony prominence at posterosuperior of calcaneus, calcaneal spur and bone formation at achilles tendon insertion. MRI can additionally show synovitis, retrocalcaneal bursitis and achilles tendinopathy. Conservative treatment is often used to treat Haglund’s syndrome, if it doesn’t respond well then surgical treatment is required. Arthroscopic calcaneoplasty with synovectomy has better outcome compared to open surgery. PRP injection can be added to enhance achilles tendinopathy healing. The AOFAS Ankle-Hindfoot score used is a standardized evaluation which combine subjective and objective information from the patient and the physician, in which a healthy ankle scored 100. In this case, the AOFAS Ankle-Hindfoot score increased significantly from 65% pre-operative to 87% post-operative which shows better functional outcome. Conclusion: Treatment of Haglund’s deformity, retrocalcaneal bursitis and achilles tendinopathy with arthroscopic calcaneoplasty, synovectomy and PRP injection should be considered to produce good functional outcome based on AOFAS Ankle-Hindfoot score..
Psychometric properties analysis of Indonesian IKDC scale for managing patients with ACL injury
Authors: Deviandri R , van der Veen HC , Lubis AMT , Postma MJ , van den Akker-Scheek I 
Published: October 2024

Introduction: The most-used questionnaire in clinical research for these patients is the International Knee Documentation Committee (IKDC) Subjective Knee Form, as its psychometric properties are considered excellent. Objectives: To assess the validity, reliability, and responsiveness of the Indonesian version of IKDC for use in the Indonesian-speaking ACL population. Material & Methods: After a forward-and-backward translation procedure and cross-cultural adaptation, validity, reliability, and responsiveness were investigated. The responses of 106 ACL injury patients on three questionnaires – the Indonesian-IKDC (I-IKDC), Short Form–36, and Kujala scores – were used. Following COSMIN guidelines, construct validity, test-retest reliability, internal consistency, floor and ceiling effects, measurement error, and responsiveness were determined. The Bland and Altman method was used to explore absolute agreement. Results: Construct validity can be considered good, as all predefined hypotheses on correlations between the I-IKDC and other scores were confirmed. Reliability proved excellent, with a high test-retest correlation (ICC=0.99). Bland and Altman analyses showed no systematic bias between test and retest. Internal consistency was good (Cronbach α .90). There were no floor or ceiling effects. Standard error of measurement (SEM) was 2.1, minimal detectable change at the individual level (MDCind) 5.8 and at the group level (MDCgrp) 0.7. Responsiveness was considered good. Conclusion: The I-IKDC appears to be a good evaluation instrument for Indonesian patients with anterior cruciate ligament injuries.
Psychometric properties analysis of Indonesian Lysholm and Tegner scales regarding COSMIN guidelines
Authors: Deviandri R , van der Veen HC , Lubis AMT , Postma MJ , van den Akker-Scheek I 
Published: October 2024

Introduction: The Lysholm knee score and Tegner activity scale are frequently used patient-reported outcome measures (PROMs) in patients with anterior cruciate ligament (ACL) injury because of their excellent psychometric properties. Objectives: To assess the validity, reliability, and responsiveness of the Indonesian version of Lysholm and Tegner scales for use in the Indonesian-speaking ACL population. Material & Methods: After a forward-and-backward translation procedure and cross-cultural adaptation, validity, reliability, and responsiveness were investigated. The responses of 106 ACL injury patients on four questionnaires – Indonesian Lysholm knee score (I-LK), Indonesian Tegner scale (I-TS), Short Form–36, and Kujala scores – were used. Following COSMIN guidelines, construct validity, test-retest reliability, internal consistency, floor and ceiling effects, measurement error, and responsiveness were determined. The Bland and Altman method was used to explore absolute agreement. Results: Construct validity is good, as more than 75% of the predefined hypotheses on correlations between I-LK, I-TS and other scores were confirmed. Reliability proved excellent, with a high test-retest correlation for both questionnaires (ICC = 0.99). Bland and Altman analyses showed no systematic bias between test and retest. Internal consistency of I-LK was good (Cronbach alpha = .73). For I-LK and I-TS, respectively, floor and ceiling effects were less than 15% (floor 0%, 4.7%; ceiling 12.3%, 3.8%); standard error of measurement (SEM) 1.8 and 0.9; minimal detectable change at the individual level (MDCind) 5.1 and 0.6, and at the group level (MDCgrp) 2.4 and 0.5. Responsiveness was considered good, especially at the group level. Conclusion: The I-LK and I-TS appears to be a good evaluation instrument for Indonesian patients with anterior cruciate ligament injuries.
Progression of Osteoarthritis After Double-Bundle Versus Single-Bundle Anterior Cruciate Ligament Reconstruction: A Systematic Review of Randomized Controlled Trial
Authors: Hasan Jafri , Tanaya Hutami Wintang Dayinta 
Published: October 2024

Introduction: Recently, anterior cruciate ligament (ACL) reconstruction procedures are frequently performed both single-bundle (SB) and double-bundle (DB) techniques. Following anterior cruciate ligament (ACL) injury, the knee suffers from a high incidence of osteoarthritis (OA), which has been decreased by ACL reconstruction using DB and SB techniques. However, there is debate regarding the extent to which the DB and SB techniques work at preventing the progression of OA after an ACL reconstruction. Methods: The databases, which included Scopus, Embase, and PubMed, were searched up. A Randomized Controlled Trial (RCT) comparing SB and DB ACL reconstruction and reporting the clinical outcomes for OA progression was included in the study. Only studies with a minimum of two years of follow-up and a ten-year time frame were included. Result: The evaluation was conducted on seven RCTs that satisfied the eligibility requirements. Overall, the studies indicate that there was no statistically significant difference in the rate of radiological OA progression between the DB group and the SB group. Conclusion: When it came to OA changes in ACL reconstruction, the DB technique was not better than the SB technique. This necessitates further research with longer follow-up periods, a larger sample size, and improved study designs.
Neglected Achilles Tendon Rupture Repair with Gastrosoleus Turn Down Flap: A Case Report
Authors: Hasan Jafri , Tanaya Hutami Wintang Dayinta 
Published: October 2024

Introduction: The most prevalent tendon rupture in the lower extremities is an achilles tendon rupture. Adults in their third to fifth decades of life are the ones who sustain the injury most frequently. The optimal method for treating these ruptures is not generally agreed upon in the literature. The objective of this study was to evaluate the functional outcomes of the gastrosoleus turn down flap method used to repair the neglected achilles tendon rupture. Methods: A 58-year-old woman who has had difficulty in walking for 6 months after slipping on the floor. The modified Lindholm method, with a turn-down of the gastrosoleus flap, was used to repair the neglected achilles tendon rupture. The patient was positioned prone, and a posterior incision was used to access the ruptured tendon. There was a complete rupture of the achilles tendon along with some fibrous tissue. The torn ends were cut into fresh tissue, and the scar tissue that had formed between the torn proximal and distal ends was resected. The gap was 10 cm. The repair was then reinforced using a 12-cm-long and 2-cm-wide segment of gastrosoleus fascia that was trimmed sharply by horizontal incision and divided into two layers, and it was then rotated 180 degrees upside down. The flap was then pulled gently but steadily in the distal direction until it bridged the gap and connected with the distal tendon. The Krackow technique was then used to suture the flap to the end of the distal stump. The tension was roughly adjusted so that the foot would be in an equinus posture with normal gravity. Results: At 6 weeks after the operation, the patient is able to walk and perform regular daily activities. No recurrent rupture and further complications were reported. Conclusion: According to this study, the gastrosoleus turn down flap method for neglected achilles tendon rupture repair provides a functional outcome that is satisfactory.
Constipation as a possible predictor of poor treatment response in chronic migraine: A retrospective study of anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies and the impact of switching
Authors: Uzun Sena , Frejvall Ulf , Petersson Per , Sahin Gürdal 
Published: October 2024

Background There is a growing awareness of constipation being a side effect of anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies (mAbs). This study aims to assess constipation as a side effect and explore its potential role as a predictor of treatment response in chronic migraine (CM) patients treated with anti-CGRP mAbs. Methods We conducted a retrospective analysis of patients with CM treated with anti-CGRP mAbs between January 2019 and December 2022 at a single center. Data on patient demographics, migraine characteristics, and constipation were reviewed. Results Among 317 patients, 192 received erenumab, 94 received fremanezumab, and 31 received galcanezumab. Constipation was significantly more common with erenumab (51.5%) compared to fremanezumab (4.2%) and galcanezumab (12.9%). Among erenumab patients, 24.4% switched due to constipation, while 19.2% switched due to lack/loss of effectiveness. Patients who switched treatment experienced milder symptoms ( p < 0.0001) without compromising effectiveness, even when switching due to lack/loss of effectiveness ( p = 0.0068). Importantly, severe constipation rates were higher in non-responders ( p = 0.036). Conclusion Constipation is a notable side effect of anti-CGRP mAbs, particularly with erenumab in CM. Side effect monitoring is consequently crucial. Our findings suggest a potential link between poor treatment response and constipation, warranting further research into the underlying mechanisms.
Soft Tissue Sarcoma: Experience  in a Tertiary Referral Center
Authors: Lahiri Anupam , Rohela Himanshu , Jain Prakhar , Batra Ullas , Chufal Kundan Singh , Goel Sneha , Negi Ritu 
Published: October 2024

Introduction This retrospective study investigates the clinical features, survival outcomes, and treatment-related results of patients with soft tissue sarcoma (STS) at a tertiary referral center in India. STSs are rare malignant tumors comprising over 50 subtypes, representing approximately 1% of adult and 15% of pediatric neoplasms. Materials and Methods We reviewed 91 patients with STS diagnosed in the Rajiv Gandhi Cancer Institute and Research Center, India, from 2020 to 2023. Data were collected on demographics, disease characteristics, and treatment outcomes. Statistical analyses were performed with survival rates estimated via the Kaplan–Meier method. Prognostic factors were evaluated through univariate and multivariate analyses using log-rank and Cox regression models. Results The study cohort included slightly more males (64.8%) than females, with 51.6% of patients under 50 years. Most tumors were over 5 cm (70.3%) and classified as Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grade 3 (62.6%). Local recurrence occurred in 7.7% of cases, and distant recurrence occurred in 24.2%. The 3-year overall survival rate was 60.5%, with a 3-year disease-free survival rate of 58%. Significant prognostic factors for better outcomes included smaller tumor size (≤5 cm), margin status (≥1 cm), lower necrosis, lower intraoperative blood loss (<100 ml), and administration of adjuvant chemotherapy. Multivariate analysis showed only intraoperative blood loss to be significant. Conclusion This study highlights the necessity of multidisciplinary care in STS management. Achieving wide surgical margins with minimal blood loss followed by multimodality treatment is crucial. Future prospective trials with larger, diverse cohorts are essential to validate these findings and optimize STS treatment strategies.
Ethyl Acetate Extract from Romdoul (Sphaerocoryne affinis) Fruit Induced Apoptosis in Human Promyelocytic Leukemia Cells
Authors: Hoai Nga Nguyen Thi , Long Tran Thanh , Ngoc Truong Thi Bich , Nguyen Nguyen Hoang Khoi , Thao Dang Thi Phuong , Trinh Nguyen Thi My 
Published: October 2024

Background Romdoul ( Sphaerocoryne affinis) is a flowering plant of the Annonaceae family and has been used customarily in folk medicine. The bioactivities of this plant, especially the anti-cancer effect, however, remain surprisingly few. Objective this study aimed to elucidate the anti-leukemic effect of romdoul fruit extracts and their underlining mechanisms. Methods The extracts were prepared from fresh fruits and the phytochemical contents were evaluated by biochemical assays and HPLC method. The promising extract was identified via the inhibition of HL60 as well as normal NIH-3T3 cell densities utilizing MTT assay. The underline mechanism of the extract’s effect was studied by accessing the treated HL60 cell population overtime (via MTT assay). The morphology of abnormal cells was examined by bright-field microscopic imaging. Hallmarks of apoptosis including nucleus characteristics and caspase 3 activation were analyzed by fluorescence imaging. The underline mechanisms of apoptosis and proliferation inhibition were accessed via RT-qPCR examination of involved genes. Results Our findings showed that the ethyl acetate extract of romdoul fruit (SA-EA) was found to be an exceptional anti-leukemic candidate (IC50 was as low as 4.11 μg/mL). More interestingly, the treated HL60 cells expressed nuclear fragmentation and caspase 3 activation, indicating the effect could follow an apoptotic mechanism. Importantly, the transcription assessment of apoptotic and proliferative genes suggested that SA-EA might suppress the growth of HL60 cells and induce p21-dependent apoptotic pathway. Conclusion This study demonstrated one of the first scientific evidence for the anti-cancer activity of Sphaerocoryne affinis fruit-derived extract. Thus, our findings exhibited a novel and promising anti-leukemic candidate for future studies.