bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a Bioabsorbable Multilayered Patch for Esophagus Tissue Engineering
Authors: Dorati Rossella , De Trizio Antonella , Marconi Stefania , Ferrara Anna , Auricchio Ferdinando , Genta Ida , Modena Tiziana , Benazzo Marco , Benazzo Alberto , Volpato Gino , Conti Bice 
Published: January 2017

A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide‐co‐polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature‐induced precipitation method, to get multilayered patches (1L, 2L, and 3L). Characterization shows stable multilayered patches (1L and 2L) by selection of copolymer type, and their M
w. In vitro investigation of the functional patch properties in simulated physiologic and pathologic conditions demonstrates that the chitosan layer (patch 3L) decreases patch stability and cell adhesion, while improves cell proliferation. Patches 2L and 3L comply with physiological esophageal pressure (3–5 kPa) and elongation (20%).
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Preparation of Forced Gradient Copolymers Using Tube‐in‐Tube Continuous Flow Reactors
Authors: Saubern Simon , Nguyen Xuan , Nguyen Van , Gardiner James , Tsanaktsidis John , Chiefari John 
Published: January 2017

AbstractThe preparation of forced gradient polymers has received considerable attention using batch reactors, while the preparation of usable quantities of forced gradient copolymers using continuous flow reactors has been hampered by the need to vary the composition of the monomer feedstock continuously during the reaction. A reactor that allows for addition of a monomer feedstock continuously at all points along the length of the reactor tubing allows for the preparation of forced gradient copolymers in continuous flow reactors, allowing for the scale‐up and bulk preparation of these polymers. This study reports here the initial investigation of preparing forced gradient copolymers using the reversible addition–fragmentation chain transfer methodology in tube‐in‐tube continuous flow reactors.
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Spatial Hadamard encoding of J‐edited spectroscopy using slice‐selective editing pulses
Authors: Chan Kimberly L. , Oeltzschner Georg , Schär Michael , Barker Peter B. , Edden Richard A.E. 
Published: January 2017

A new approach for simultaneous dual‐voxel J‐difference spectral editing is described, which uses spatially selective spectral‐editing pulses and Hadamard encoding. A theoretical framework for spatial Hadamard editing and reconstruction for parallel acquisition (SHERPA) was developed, applying gradient pulses during the frequency‐selective editing pulses. Spectral simulations were performed for either one (gamma‐aminobutyric acid, GABA) or two molecules (glutathione and lactate) simultaneously detected in two voxels. The method was tested in a two‐compartment GABA phantom, and finally applied to the left and right hemispheres of 10 normal control subjects, scanned at 3 T.SHERPA was successfully implemented at 3 T and gave results in close agreement with conventional MEGA‐PRESS scans in both the phantom and in vivo experiments. Simulations for GABA editing for (3 cm)3 voxels in the left and right hemispheres suggest that both editing efficiency losses and contamination between voxels are about 2%. Compared with conventional single‐voxel single‐metabolite J‐difference editing, two‐ or fourfold acceleration is possible without significant loss of SNR using the SHERPA method. Unlike some other dual‐voxel methods, the method can be used with single‐channel receiver coils, and there is no SNR loss due to unfavorable receive‐coil geometry factors.
Specification, composition, and placement of network services with flexible structures
Authors: Dräxler Sevil , Karl Holger 
Published: January 2017

SummaryNetwork function virtualization and software‐defined networking allow services consisting of virtual network functions to be designed and implemented with great flexibility by facilitating automatic deployments, migrations, and reconfigurations for services and their components. For extended flexibility, we go beyond seeing services as a fixed chain of functions. We define the service structure in a flexible way that enables changing the order of functions in case the functionality of the service is not influenced by this and propose a YANG data model for expressing this flexibility. Flexible structures allow the network orchestration system to choose the optimal composition of service components that, for example, gives the best results for placement of services in the network. When number of flexible services and number of components in each service increase, combinatorial explosion limits the practical use of this flexibility. In this paper, we describe a selection heuristic that gives a Pareto set of the possible compositions of a service as well as possible combinations of different services, with respect to different optimization objectives. Moreover, we present a heuristic algorithm for placement of a combination of services, which aims at placing service components along shortest paths that have enough capacity for accommodating the services. By applying these solutions, we show that allowing flexibility in the service structure is feasible.
An adaptive variational Quasicontinuum methodology for lattice networks with localized damage
Authors: Rokoš O. , Peerlings R. H. J. , Zeman J. , Beex L. A. A. 
Published: January 2017

SummaryLattice networks with dissipative interactions can be used to describe the mechanics of discrete meso‐structures of materials such as 3D‐printed structures and foams. This contribution deals with the crack initiation and propagation in such materials and focuses on an adaptive multiscale approach that captures the spatially evolving fracture. Lattice networks naturally incorporate non‐locality, large deformations and dissipative mechanisms taking place inside fracture zones. Because the physically relevant length scales are significantly larger than those of individual interactions, discrete models are computationally expensive. The Quasicontinuum (QC) method is a multiscale approach specifically constructed for discrete models. This method reduces the computational cost by fully resolving the underlying lattice only in regions of interest, while coarsening elsewhere. In this contribution, the (variational) QC is applied to damageable lattices for engineering‐scale predictions. To deal with the spatially evolving fracture zone, an adaptive scheme is proposed. Implications induced by the adaptive procedure are discussed from the energy‐consistency point of view, and theoretical considerations are demonstrated on two examples. The first one serves as a proof of concept, illustrates the consistency of the adaptive schemes and presents errors in energies. The second one demonstrates the performance of the adaptive QC scheme for a more complex problem. Copyright © 2017 John Wiley & Sons, Ltd.
pH and temperature responsiveness in AgNPs stabilized by a new poly(vinylidene fluoride) random graft copolymer
Authors: Kuila Atanu , Maity Nabasmita , Chatterjee Dhruba P. , Nandi Arun K. 
Published: January 2017

ABSTRACTPoly(vinylidene fluoride)(PVDF)‐graft‐random copolymers(PD) of diethyleneglycol methylether methacrylate(MeO2MA) and dimethylaminoethyl methacrylate(DMAEMA) are synthesized by a combined atom transfer radical coupling and atom transfer radical polymerization technique at three different co‐monomer compositions. The molar ratio of MeO2MA to DMAEMA in PD are measured to be 1:5.8, 1:1.3, and 1:0.5 for PD1, PD2, and PD3 graft copolymers. In PD2 the feed ratio and mole ratio are same indicating an azeotropic composition causing highest yield (89%) and highest molecular weight (9.29 × 105). The grafted chains of PD are temperature and pH responsive and in basic pH they show a sudden increase in size above certain temperature for LCST‐type phase transition, however, this is not observed at pH 4 and 7. PD can generate AgNPs under UV irradiation and morphology of PD at 30 °C varies with pH from vesicle to nanosphere. The AgNPs lie on the surface of the vesicles or assemble with the PD chains forming nanosphere morphology. At different pH, PD samples exhibit plasmon peaks at different wavelengths attributed to various size, shapes and cluster formation. The UV–vis spectra of AgNPs stabilized by PD1 and PD2 samples exhibits similar LCST‐type phase transition as observed above, but that of PD3 does not show any such transition. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 960–970
Polybenzobisimidazole‐derived two‐dimensional supramolecular polymer
Authors: Seo Wanji , Carpenter Keith L. , Gaugler James A. , Shao Wenting , Werling Keith A. , Fournier Philip M. , Lambrecht Daniel S. , Star Alexander 
Published: January 2017

ABSTRACTWe report a novel crystalline supramolecular polybenzobisimidazole (SP‐PBBI) capable of providing a two‐dimensional polymer (2DSP‐PBBI) by liquid‐phase exfoliation. A regular arrangement of rigid rod‐like polybenzobisimidazole (PBBI) chains is achieved by interchain hydrogen bonding. Titration of 2DSP‐PBBI with cobalt chloride (CoCl2) using UV‐Vis spectroscopy demonstrates the presence of bidentate NO ligands on the PBBI backbone and NO–Co(II) complexation. Imaging analysis using atomic force microscopy (AFM) reveals the planar surface morphology of exfoliated 2DSP‐PBBI sheets with lateral dimensions of <1 μm and thickness of <30 nm. The size of the polymer crystal growth is tuned by employing condensation/precipitation polymerization under nonisothermal conditions. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1095–1101
The IDL of E. coli SSB links ssDNA and protein binding by mediating protein–protein interactions
Authors: Bianco Piero R. , Pottinger Sasheen , Tan Hui Yin , Nguyenduc Trong , Rex Kervin , Varshney Umesh 
Published: January 2017

AbstractThe E. coli single strand DNA binding protein (SSB) is essential to viability where it functions in two seemingly disparate roles: it binds to single stranded DNA (ssDNA) and to target proteins that comprise the SSB interactome. The link between these roles resides in a previously under‐appreciated region of the protein known as the intrinsically disordered linker (IDL). We present a model wherein the IDL is responsible for mediating protein–protein interactions critical to each role. When interactions occur between SSB tetramers, cooperative binding to ssDNA results. When binding occurs between SSB and an interactome partner, storage or loading of that protein onto the DNA takes place. The properties of the IDL that facilitate these interactions include the presence of repeats, a putative polyproline type II helix and, PXXP motifs that may facilitate direct binding to the OB‐fold in a manner similar to that observed for SH3 domain binding of PXXP ligands in eukaryotic systems.
Superparasitism, immune response and optimum progeny yield in the gregarious parasitoid Palmistichus elaeisis
Authors: de S Pereira Kleber , Guedes Nelsa Maria P , Serrão José E , Zanuncio José C , Guedes Raul Narciso C 
Published: January 2017

AbstractBACKGROUNDThe subsequent deposition of an egg clutch by a female parasitoid into a host already parasitised either by itself or a conspecific (i.e. superparasitism) is a counterintuitive adaptive strategy, particularly considering the female parasitoid's ability to recognise the parasitised hosts. Such a scenario suggests that the adaptive value of superparasitism depends on the number of clutches laid in the same host, with consequences for parasitoid progeny yield. Here, we tested whether such is the case for the gregarious parasitoid Palmistichus elaeisis and explored its underlying basis.RESULTSAllowing female parasitoids to lay multiple egg clutches in a single melonworm host pupa, parasitoid progeny and fitness exhibited a peak or optimum at three egg clutches laid per host pupa. In addition, haemocyte count, encapsulation and melanisation decreased with the number of egg clutches laid per host pupa.DISCUSSIONAn optimum number of three clutches laid per host pupa was detected for P. elaeisis. As immune response via haemocyte production, encapsulation and melanisation decreased with the number of clutches laid per host, the higher parasitoid yield and fitness observed is the likely consequence of a compromised immune response coupled with an accommodative (i.e. scramble) larval competitive strategy allowing enough resources for optimum balance of parasitoid number and quality produced. © 2017 Society of Chemical Industry
Decentralized fault detection and isolation of Markovian jump interconnected systems with unknown interconnections
Authors: Li Li‐Wei , Yang Guang‐Hong 
Published: January 2017

SummaryThis paper investigates the decentralized fault detection and isolation (FDI) problem for Markovian jump interconnected systems with unknown interconnections. Different from the existing decentralized FDI approaches, the requirement for access to operation modes of all subsystems, which is unreasonable and hard to meet in realistic applications, is removed. By utilizing local measurements and neighboring mode information, a decentralized FDI filter is constructed to generate a residual for each subsystem of Markovian jump interconnected system. Then, a new design method is developed such that the resulting augmented system is stochastically stable and the generated residual is sensitive to local fault. In addition, the proposed method can achieve fault detection and isolation simultaneously. Finally, two examples are given to illustrate the effectiveness and merits of the new results. Copyright © 2017 John Wiley & Sons, Ltd.
Surface Mediated Hierarchical Assemblies of Highly Hydrophobic Phenylalanine‐Based Peptides
Authors: Mayans Enric , Fabregat Georgina , Juárez Ruben , Cativiela Carlos , Puiggalí Jordi , Alemán Carlos 
Published: January 2017

AbstractWe report the noticeable control exerted by the surface in the self‐assembly of a highly hydrophobic triphenylalanine peptide with fluorenyl functionalities blocking the two ends. The remarkable differences observed among the polymorphic hierarchical assemblies obtained onto silanized glass, scratched glass, stainless steel, exfoliated mica, silicon wafer, carbon, polytetrafluoroethylene, plasma‐functionalized, polystyrene and nitrocellulose substrates are consequence of the balance between peptide⋅⋅⋅peptide and peptide⋅⋅⋅surface interactions. This balance is greatly influenced by the surface characteristics, as defined by the wettability (hydrophobicity or hydrophilicity) and roughness (degree of flatness and regularity). Furthermore, very stable dendritic structures, in which primary frameworks nucleated from the center grow according to a 4‐fold pseudo‐symmetry branching, have been obtained onto hydrophilic treated polystyrene.
Chloride Platinum(II) Coordination Compounds with4’‐Substituted Terpirydine Ligands as Donor‐Acceptor‐Donor Systems ‐ Structural, Electrochemical and Luminescence Studies.
Authors: Maroń Anna , Czerwińska Katarzyna , Małecki Jan G. , Machura Barbara , Szłapa‐Kula Agata , Krompiec Stanisław 
Published: January 2017

AbstractPlatinum(II) coordination compounds with formulas [PtCl(L)]Cl, (where L=4’‐(2,2’‐bithiophen‐5‐yl)‐2,2′:6′,2”‐terpyridine (L1), 4’‐(4‐dimethylaminophenyl)‐2,2′:6′,2”‐terpyridine (L2),4’‐(2,4‐difluorophenyl)‐2,2′:6′,2”‐terpyridine (L3)), were synthesized from K2[PtCl4] precursor and characterized by X‐ray crystallography, FT‐IR, NMR, UV‐Vis spectroscopy and electrochemical studies. The emission properties of the compounds were studied in solutions and in solid state at ambient temperature and in methanol : ethanol frozen glass matrix at 77 K. The quantum yields of fluorescence, the lifetimes and the nature of excited states were described on the basis of the molecular properties. Theoretical calculations, with usage of DFT method, were undertaken to elucidate the structural, spectroscopic and bonding properties of the synthesized coordination compounds.
Development of Zinc Oxide Sensors for Detecting Ammonia Gas in the Ambient Air: A Critical Short Review
Authors: Chatterjee Bappaditya , Bandyopadhyay Amitava 
Published: January 2017

Ammonia (NH3) is emitted into the atmosphere by various industries and other sources and causes environmental pollution. Considering the hazards of ammonia, detecting leakage from vessels and pipes demands the use of sensors. Therefore, the development of NH3 gas sensors assumes considerable importance to researchers and regulators and to industry, businesses, and facilities that make, store, or use ammonia. The use of metal oxide sensors (MOS) for detecting NH3 gas, such as zinc oxide (ZnO), has been a topic of interest to researchers seeking methods to detect NH3 gas, even at low concentrations. In this article, an attempt has been made to review the research thus far published on the synthesis of ZnO‐based NH3 gas sensor materials, their characterization, and analyses of their performance. Finally, we make several recommendations regarding the scope of future research. For example, the kinetics of the sensor materials shouldbe determined. Furthermore, extensive studies of gas–solid (NH3–ZnO) adsorption are proposed to ascertain the exact adsorption mechanism in terms of isotherm, kinetics, and diffusive mass transport, and to determine “reversibility” and “recovery” of sensor materials so they can continue sensing and activating alarms when necessary for practical applications.
A multi‐anchoring approach in mobile IP networks
Authors: Wang You , Bi Jun , Jiang Xiaoke 
Published: January 2017

AbstractMany recent mobility solutions, including derivatives of the well‐known Mobile IP as well as emerging protocols employed by future Internet architectures, propose to realize mobility management by distributing anchoring nodes (Home Agents or other indirection agents) over the Internet. One of their main goals is to address triangle routing by optimizing routes between mobile nodes and correspondent nodes. Thus, a key component of such proposals is the algorithm to select proper mobility anchoring nodes for mobile nodes. However, most current solutions adopt a single‐anchoring approach, which means each mobile node attaches to a sole mobility anchor at one time. In this paper, “we argue that the single‐anchoring approach has drawbacks when facing various mobility scenarios. Then, we offer a novel multi‐anchoring approach that allows each mobile node to select an independent mobility anchor for each correspondent node. We show that in most cases our proposal gains more performance benefits with an acceptable additional cost by evaluation based on real network topologies. For the cases that lead to potential high cost, we also provide a lightweight version of our solution which aims to preserve most performance benefits while keeping a lower cost. At last, we demonstrate how our proposal can be integrated into current Mobile IP networks. Copyright © 2017 John Wiley & Sons, Ltd.
Wind speed generation for dynamic analysis
Authors: Fernandez‐Bernal F. , Alonso‐Alonso J. 
Published: January 2017

AbstractA simple model to generate large band wind speed time sequences, especially easy to implement with a very reduced number of parameters, is presented. It is based on the calculation of a low‐frequency and a high‐frequency components. Low‐frequency component with 1 h sample time is obtained from a random process based on a conditional probability density function. Using real data from two different wind farms in two different months of the year, it has been found that Weibull distribution centered in the current hourly mean value seems to represent well the 1 h conditional PDF in all cases, and the standard deviation of this conditional Weibull is more or less in the range 1–1.3 m s−1 independently of the season of the year or the location. Regarding to high‐frequency component, low‐frequency samples are used as initial and final values and, between them, the turbulence component values are inserted. For that, it has been used a stochastic process based on a Beta probability function and a simple rescaling procedure with two non‐linear parameters, calculated in a recursive way. Unlike the usual modelling procedures presented in the literature, spectral power density functions are not used. This simplifies the implementation significantly. Ten second sample‐time real speed wind data from two different wind farms have been used to validate the proposed high‐frequency model, obtaining excellent results. A thorough revision of the main models found in the literature to produce wind speed time sequences for dynamic analysis is performed in the paper. Copyright © 2017 John Wiley & Sons, Ltd.
Das Tumorepigenom – von der Genregulation über die Tumorklassifikation zum Therapietarget
Authors: Ammerpohl Ole , Deckert Martina , Montesinos-Rongen Manuel 
Published: January 2017

Zusammenfassung
Epigenetische Regulationsmechanismen sind essenziell für den koordinierten Ablauf zahlreicher zellulärer Prozesse wie die Differenzierung und Entwicklung oder auch die Anpassung der Genaktivität an die herrschenden Umweltbedingungen. Insbesondere Tumorerkrankungen gehen mit oftmals umfangreichen Alterationen im Epigenom einher. Diese Veränderungen sind dabei vielfach charakteristisch entweder für die Tumorentität, das Stadium der Erkrankung oder aber das klinische Ansprechen des Tumors auf eine Therapie und damit die individuelle Prognose des Patienten. Nach einer kurzen Darstellung epigenetischer Marker und ihrer Bedeutung bei malignen Erkrankungen werden in diesem Artikel Alterationen im Tumorepigenom und ihre Nutzbarkeit im Rahmen einer individualisierten Medizin exemplarisch vorgestellt.
Experiences of Remote Mood and Activity Monitoring in Bipolar Disorder: A Qualitative Study
Authors: Saunders K.E.A. , Bilderbeck A.C. , Panchal P. , Atkinson L.Z. , Geddes J.R. , Goodwin G.M. 
Published: January 2017

AbstractBackgroundMobile technology enables high frequency mood monitoring and automated passive collection of data (e.g. actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are increasingly being deployed in research and clinical settings however little is known about how such approaches are experienced by patients. Here, we explored the experiences of individuals with bipolar disorder engaging in a study involving mood and activity monitoring with a range of portable and wearable technologies.MethodPatients were recruited from a wider sample of 50 individuals with Bipolar Disorder taking part in the Automated Monitoring of Symptom Severity (AMoSS) study in Oxford. A sub-set of 21 patients participated in a qualitative interview that followed a semi-structured approach.ResultsMonitoring was associated with benefits including increased illness insight, behavioural change. Concerns were raised about the potential preoccupation with, and paranoia about, monitoring. Patients emphasized the need for personalization, flexibility, and the importance of context, when monitoring mood.ConclusionsMobile and electronic health approaches have potential to lend new insights into mental health and transform healthcare. Capitalizing on the perceived utility of these approaches from the patients’ perspective, while addressing their concerns, will be essential for the promise of new technologies to be realised.