bluuebunny/crossref_metadata_2025_split huggingface dataset:
The foundation of the rhubarb industry economy: investigating metabolites disparities of rhubarb between varieties and growing environments on the Tibetan plate
Authors: Zou Jinpeng , Wu Wei , Wang Fang , Hou Kai 
Published: September 2024

ObjectiveIn Tibetan dietary and folk medicine practices, Rheum austral is commonly used as an alternative to Rheum tanguticum, and there is a prevailing belief that wild rhubarb should not be substituted by its cultivated counterpart. However, these traditions are not supported by scientific evidence, particularly concerning the differences in endogenous metabolites between cultivated and wild rhubarbs, as well as between officially recognized and non-official rhubarbs. These uncertainties have also been hindering the vertical integration development of the local rhubarb industry.MethodsIn this study, ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOFMS) and biostatistical analysis were employed to systematically and comprehensively investigate the chemical constituents of rhubarbs from various sources, focusing on the differences in metabolic components between cultivated and wild rhubarbs.ResultsThe metabolic differences in rhubarb from various varieties and environments are pronounced. Among them, 39 differential metabolites were identified between cultivated R. tanguticum and wild R. tanguticum. cultivated R. tanguticum is rich in emodin, physcion, and rhapontigenin, whereas wild R. tanguticum exhibits a higher concentration of rhaponticin and is particularly abundant in anthraquinone compounds. Additionally, 33 differential metabolites distinguished wild R. tanguticum from wild R. austral, with R. austral being rich in stilbene derivatives and wild R. tanguticum predominantly containing coumarins. The correlations among these differential metabolites have also been further explored and presented.ConclusionThe metabolic disparities between cultivated and wild rhubarb varieties are substantial, with wild rhuabarb containing higher levels of effective components than its cultivated counterparts. However, wild varieties face issues with component instability and resource depletion, while cultivated varieties exhibit more stable effective components. Given these significant differences in metabolic components, it is essential to differentiate rhubarbs from various species and growing conditions to suit specific medicinal and dietary purposes effectively. This paper can lay a theoretical foundation for the vertical integration development of the rhubarb industry in Tibetan areas.
Heart-specific expression of the green fluorescent protein gene in avian embryos by administration of recombinant adenovirus type-5 vector into the embryonic blood vessel
Authors: Choi Wonjun , Lee Joonbum , Kim Dong-Hwan , Ma Evan , Suh Yeunsu , Lee Sang-Suk , Lee Kichoon 
Published: September 2024

Genetic modification in vivo could provide direct functions of genes that could potentially contribute to diverse areas of research including genetics, developmental biology, and physiology. It has been reported that genes of interest could be introduced via recombinant adenovirus type 5 (Ad5) in poultry. Successful gene delivery to mammal fetuses in utero promises substantial progress in clinical and developmental biology, but it is limited because of difficulties in injecting specific sites and invasiveness. On the other hand, developing avian embryos are easily accessible by making a window on the eggshell. Therefore, the objective of this study is to determine permissive embryonic stages for gene transfer into specific avian tissue/organs by injection of Ad5 containing the green fluorescent protein (GFP) gene into blood vessels. At 2 d of post-injection, a strong GFP signal was predominantly identified in the heart of chicken embryos injected at Hamilton–Hamburger (HH) 14, 15, 16 and17 stages with the percentages (44%, 53%, 25%, and 14%, respectively) of GFP positive embryos. In quail embryos, the injection at the HH 15 resulted in heart-specific expression of GFP. Western blot analysis revealed that GFP was exclusively expressed in the avian hearts. These results suggest that the GFP gene is specifically delivered to the avian embryonic hearts when Ad5 is injected through the blood vessel at HH 14–17. This adenoviral transduction of genes of interest in avian embryonic hearts can provide new models for understanding functions of genetic factors on embryonic heart development and unravel genetic etiology of congenital heart diseases.
GP working time and supply, and patient demand in England in 2015–2022: a retrospective study
Authors: Parisi Rosa , Lau Yiu-Shing , Bower Peter , Checkland Katherine , Rubery Jill , Sutton Matthew , Giles Sally , Esmail Aneez , Spooner Sharon , Kontopantelis Evangelos 
Published: September 2024

BackgroundEnglish primary care faces a reduction in GP supply and increased demand.AimTo explore trends in GP working time and supply, accounting for factors influencing demand for services.Design and settingRetrospective observational study in English primary care between 2015 and 2022.MethodTrends in median GP contracted time commitment were calculated using annual workforce datasets. Three measures of demand were calculated at practice-level: numbers of patients; numbers of older patients (≥65 years); and numbers of chronic conditions using 21 Quality and Outcomes Framework disease registers. Multi-level Poisson models were used to assess associations between GP supply and practice demand, adjusted for deprivation, region, and year.ResultsBetween 2015 and 2022, the median full-time equivalent (FTE) of a fully qualified GP decreased from 0.80 to 0.69.There was a 9% increase in registered population per GP FTE (incidence rate ratio [IRR] = 1.09; 95% confidence interval [CI] = 1.05 to 1.14). This increase was steeper using numbers of chronic conditions (32%, IRR = 1.32; 95% CI = 1.26 to 1.38). Practices in the most deprived decile had 17% more patients (IRR = 1.17; 95% CI = 1.08 to 1.27) and 19% more chronic conditions (IRR = 1.19; 95% CI = 1.06 to 1.33) per GP FTE, compared with the least deprived decile. These disparities persisted over time. All regions reported more chronic conditions per GP FTE than London.ConclusionPopulation demand per GP has increased, particularly in terms of chronic conditions. This increase is driven by several factors, including a reduction in GP contracted time commitments. Persistent deprivation gradients in GP supply highlight the need to recruit and retain GPs more equitably.
Multipolarity in the Arctic: New economic opportunities and geopolitical risks for Russia, India and China
Authors: Pitukhina M. A. , Gurtov V. A. , Belykh A. D. 
Published: September 2024

Aim. To show new economic opportunities and geopolitical risks for Russia, India and China through the opening of new trade routes, such as the Northern Sea Route and the North-South International Transport Corridor, as factors in the formation of multipolarity in the Arctic. Objectives. To analyze the extent to which new transport arteries will serve to reduce trade costs and improve economic ties between the People’s Republic of China (PRC), Russia and India; to assess whether new opportunities for cooperation between Russia and the leading countries of the Asia-Pacific region will be created in the near future. Methods. The research methodology is based on analyzing a list of key Chinese projects in the Arctic over the past ten years and a list of key Indian projects over the past five years. Results. The priorities of China and India in their interaction with Russia in the Arctic direction are demonstrated. Thus, China is actively promoting the concept of the Polar Silk Road (PSR). The PSP is a continuation of the Chinese initiative “One Belt, One Road” in the Arctic, which in 2013. Xi Jinping proclaimed to revitalize East-West trade along the historic Silk Road route.The development of alternative routes for China is also important in terms of the “Malacca dilemma,” that is, China’s vulnerability to maritime blockade due to the limited number of alternative routes and potential control by outside powers. India, for its part, is lobbying for another project, the INSTC (International North-South Transport Corridor), which acts as an alternative to China’s One Belt, One Road initiative but also provides a 25-day trade route from Russia. Conclusions. The list of large-scale projects being implemented by China to develop Arctic resources over the past ten years demonstrates a high interest in preserving the Polar region as a territory of constructive dialog and mutually beneficial cooperation. The sphere of mutual cooperation with China in the Arctic is wide: shipbuilding, timber industry, fuel and energy complex (FEC), nuclear power, and industrial equipment. Cooperation with India is developing in a somewhat different aspect; the list of India’s key Arctic projects in the Arctic is less voluminous than that with China. The projects are mainly focused on the resource potential of the Arctic fuel and energy complex. The impression is that India is trying to seek benefits for itself more than working with Russia on the terms of a mutually beneficial partnership. In addition, India has received an invitation to join NATO, which demonstrates the existence of favorable relations with the alliance.
HUBUNGAN ANTARA STATUS GIZI, STRES, DAN KONSUMSI MINUMAN BERKAFEIN DENGAN PRIMARY DYSMENORRHEA PADA MAHASISWI UNIVERSITAS NEGERI SEMARANG
Authors: Latifah Nurul Husniah , Farida Eko 
Published: September 2024

Primary Dysmenorrhea (PD) adalah nyeri menstruasi yang tidak berhubungan dengan patologi panggul dan karakteristiknya adalah nyeri pada bagian suprapubik saat beberapa jam sebelum atau ketika menstruasi. Dari hasil penelitian tahun 2015 dan 2017 lebih dari 50% wanita sering mengalami primary dysmenorrhea, prevalensi primary dysmenorrhea di Indonesia adalah 54,89%. Kebaruan dalam penelitian ini karena menganalisis hubungan antara status gizi, stres, dan konsumsi minuman berkafein dengan primary dysmenorrhea. Tujuan penelitian untuk menganalisis hubungan antara status gizi, stres, dan konsumsi minuman berkafein dengan primary dysmenorrhea pada mahasiswi Universitas Negeri Semarang. Kriteria inklusi adalah mahasiswi tingkat akhir Universitas Negeri Semarang yang berada di Semarang, berusia 18-24 tahun, belum menikah, dan bersedia mengisi rangkaian kuesioner hingga akhir. Desain penelitian menggunakan desain cross sectional dengan perhitungan sampel sebanyak 95 mahasiswi dengan teknik stratified random sampling. Instrumen yang digunakan adalah kuesioner Verbal Multidimensional Scoring System for dysmenorrhea (VMS), Depression Anxiety Stress Scale-42 (DASS-42), Semi Quantitative Food Frequency Questionnaire (SQ-FFQ), serta pengukuran antropometri secara langsung menggunakan microtoise dan timbangan berat badan digital. Analisis data menggunakan uji korelasi chi-square dan uji fisher. Hasil penelitian menunjukan bahwa ada hubungan yang signifikan antara stres (P-value= 0,027) dan konsumsi minuman berkafein (P-value=0,031) dengan primary dysmenorrhea, serta tidak ada hubungan yang signifikan antara status gizi (P-value=0,096) dengan primary dysmenorrhea. Kesimpulan bahwa ada hubungan yang signifikan antara stres dan konsumsi minuman berkafein dengan primary dysmenorrhea, sedangkan status gizi tidak berhubungan secara signifikan dengan primary dysmenorrhea pada mahasiswi tingkat akhir Universitas Negeri Semarang.
CANDUNGA, DE BRUNO DE MENEZES: UM ROMANCE UTÓPICO E UNIVERSAL NA AMAZÔNIA PARAENSE
Authors: Sousa Willian Ferreira de 
Published: September 2024

O presente trabalho faz algumas reflexões sobre o romance Candunga (1954), de Bruno de Menezes (1893-1963), escritor negro, pobre e nascido na periferia de Belém (PA), que usou a literatura, o cooperativismo e o sindicalismo como forma de resistência e luta em prol de uma sociedade justa e igualitária. O livro resguarda as principais características da segunda geração modernista, como as temáticas sociais, dialogando com outras obras desse período, mas o autor paraense e sua produção não obtiveram o destaque necessário pelo cânone. Este artigo visa demonstrar a importância da narrativa e de seu autor, evidenciando-os com características universais, cuja classificação perpassa o regionalismo. As reflexões aqui propostas trilham pela natureza utópica do romance de Menezes que se destaca pelo teor libertário e revolucionário, bem como os conceitos de sedenarrativa e aquonarrativa que emergem do texto. Para essa discussão, alguns autores foram evocados: Bosi (1994); Cândido (2006); Jobim (2020; 2021); Eagleton (1976); Leão e Campos (2021); Lukács (2000); Nunes (2001; 2004) entre outros. Enfim, este trabalho tem como principal base de análise a metodologia qualitativa e envolve pesquisas bibliográficas, cujas informações apontam a importância do romance em tela e de seu autor para o cenário literário amazônico e brasileiro.
DESAFIOS E IMPACTOS DA EDUCAÇÃO SEXUAL NAS ESCOLAS BRASILEIRAS
Authors: Bittencourt Giovanna Galetti , Chofard Mariana Souza , Almeida Hosana de Araújo , Missioneiro Carlos Henrique Pinto , Vargas Adriana Cunha , Silva Mateus Batista 
Published: September 2024

A adolescência é período que compreende a transição da vida infantil para a vida adulta, atualmente, delimitada pela faixa etária entre 12-19 anos. Ademais, é de conhecimento comum que essa fase da vida é composta por diversas mudanças, tais como corporais, cognitivas e comportamentais, incluindo a afloração da sexualidade. Nesse ponto, a percepção de que essa fase é problematizada é necessário prestar atenção às necessidades desses jovens, que muitas vezes são deixados de lado, trazendo dúvidas, escolhas errôneas e inseguranças sobre questões sexuais. Portanto, essa revisão teve como objetivo mostrar a importância da inclusão de aulas sobre educação sexual em escolas, para alunos do ensino fundamental II. Para tanto, foram analisados 14 (quatorze), de grandes bases científicas, como Pubmed, Scielo e Lilacs, utilizando os descritores em ciência da saúde: Educação sobre sexualidade, ensino básico e gravidez na adolescência. Tais artigos que abordaram o impacto da educação sexual sobre os adolescentes do ensino fundamental das escolas brasileiras. Os artigos examinaram definições, fatores de risco para gestação precoce em adolescentes, consequências e fisiologia do desenvolvimento sexual nessa faixa etária, além do impacto que a educação sexual tem sobre esses adolescentes.
Analysis of Alternative Heat Exchangers Based on Thermosyphons in Heat Supply Systems
Authors: Гатауллина А.Р. 
Published: September 2024

Постановка задачи. Нагрев приточного воздуха и воды в системах теплоснабжения в настоящее время производится с использованием рекуперативных теплообменных аппаратов. В качестве теплоносителя используется нагретая вода и энергия высокопотенциальных источников тепла. Актуальным вопросом является оптимизация использования энергии низкопотенциальной теплоты с целью повышения энергоэффективности в системах теплоснабжения. Результаты. Выполнен сравнительный анализ тепловой эффективности термосифонного и традиционного теплообменных аппаратов в системах теплоснабжения и горячего водоснабжения. Выводы. Внедрение термосифонных теплообменных аппаратов требует больших материальных вложений, и их работа менее эффективна, но в некоторых схемах сопоставима с традиционными теплообменными аппаратами. В связи с этим применение схем с термосифонами - актуальная задача в системе теплоснабжения.
Statement of the problem. Heating of supply air and water in heat supply systems is currently carried out using recuperative heat exchangers. Heated water and energy from high-potential heat sources are used as a coolant. Currently, a pressing issue is the optimization of the use of low-grade heat energy in order to increase energy efficiency in heat supply systems. Results. A comparative analysis of the thermal efficiency of thermosiphon and traditional heat exchangers in heat supply and hot water supply systems has been carried out. Conclusions. The introduction of thermosiphon heat exchangers requires large material investments and their operation is less efficient, but in some schemes it is comparable to traditional heat exchangers. In this regard, the use of circuits with thermosiphons is an urgent task in the heat supply system.
Los desechos de talla en Colmillo Sur I (NO de Santa Cruz, Patagonia Argentina)
Authors: Dekmak Wendy 
Published: September 2024

Lithic resources serve as indicators of the diversity of activities conducted at a site,
offering insights into the nature of its occupations. This study delves into the character of the Colmillo Sur I site (South-central Patagonia), which was persistently occupied during certain periods, from 7,424 to 535 cal AP. To do so, our investigation explored the informative potential of knapping debitage from a reduction sequence perspective. Our results provide deeper insights and expand upon previously identified trends at the site. We identified that activities involving different raw materials were generally similar but characterized by dissimilarities based on their quality and origin. Furthermore, these trends remained generally stable in most of its occupations. This suggested a consistent character throughout the site's occupational history.
Pemanfaatan Limbah Kulit Singkong Sebagai Absorban Alami Untuk Mengurangi Kadar Besi (Fe) Pada Air Sumur
Authors: Nakoe Moh Rivai , Ahmad Zul Fikar , Arsad Nikmatisni 
Published: September 2024

Air yang digunakan masyarakat sebagai air minum dan kebutuhan sehari-hari seperti mandi, cuci piring, mandi, dan lainnya sebagainya harus aman dan memenuhi berbagai syarat yang telah ditentukan. Ditemukan beberapa sumur di Desa Toto Selatan mengandung kadar zat besi (Fe). Tujuan pengabdian ini adalah untuk meningkatkan pemahaman tentang pemanfaatan serbuk kulit singkong dalam menurunkan kadar zat besi (Fe) pada air sumur. Mitra kegiatan ini Pemerintah Desa Toto Selatan Kecamatan Kabila. Metode yang digunakan adalah ceramah dan praktek yang diberikan dalam bentuk sosialisasi dan pelatihan pembuatan serbuk kulit singkong. Hasil pengabdian masyarakat ini menunjukan serbuk kulit singkong efektif dalam menurunkan kadar zat besi (Fe) pada air, terjadi peningkatan kemampuan masyarakat untuk menggunakan bahan alami kulit singkong untuk menurunkan kadar zat besi (Fe) pada air sumurnya, masyarakat mendapat transfer pengetahuan yang dapat diaplikasikan secara langsung dengan alat dan bahan yang mudah didapat, dan Masyarakat dapat menjual serbuk kulit singkong untuk menambah penghasilan keluarga.
Madura dan Potensi Wisata Rempah: Kajian Strategi Komunikasi Pemasaran Pariwisata
Authors: Suryandari Nikmah , Rahmawati Farida Nurul , Adhidharma Ferry 
Published: September 2024

PPandemi COVID-19 sempat menghentikan aktivitas industri pariwisata global. Kondisi ini makin diperparah oleh suasana ketidakpastian dan kurangnya vaksinasi yang efektif. Hal ini berakibat orang mulai mencoba berbagai obat untuk meningkatkan kekebalan mereka,beralih ke praktik medis tradisional dan pengobatan alternatif. Penggunaan rempah dalam makanan maupun jamu dikenal sebagai salah satu potensi wisata Madura. Penelitian ini bertujuan mengetahui strategi komunikasi pemasaran pariwisata produk rempah Madura. Tulisan ini menyajikan ceruk sektor pariwisata yang menekankan potensi wisata rempah. Penelitian bertujuan mengetahui strategi komunikasi untuk mempromosikan pariwisata berbasis rempah dan untuk pengembangan wisata Madura. Penelitian menggunakan metode deskriptif kualitatif dengan informan para pelaku usaha wisata berbasis rempah di Madura. Hasil penelitian menunjukkan bahwa penggunaan strategi komunikasi pemasaran pariwisata di Madura menggunakan perspektif bauran pemasaran 7P yaitu dengan produk, harga, tempat, promosi, orang, proses, bukti fisik.
Pengaruh Iklan Live Streaming Shopee terhadap Keputusan Pembelian Dimoderasi oleh Sikap
Authors: Elfera Syahedah Soeci , Sugiana Dadang , Bakti Iriana 
Published: September 2024

Live streaming merupakan sebuah fenomena baru dan menjadi salah satu strategi pemasaran digital yang efektif untuk menarik perhatian konsumen dan mendorong keputusan pembelian. Artikel ini bertujuan untuk menganalisis pengaruh cognitive response pada iklan live streaming e-commerce terhadap keputusan pembelian. Penelitian dilakukan dengan menggunakan metode kuantitatif. Data dikumpulkan melalui survei kepada 96 responden yang pernah melakukan pembelian pada e-commerce Shopee dan menonton live streaming. Pengujian data menggunakan Path Analysis dengan teknik analisis Structural Equation Modeling (SEM) melalui pengolahan Partial Least Square (PLS). Hasil penelitian menunjukkan bahwa cognitive response pada iklan live streaming memiliki pengaruh positif terhadap keputusan pembelian melalui sikap sebagai variabel mediasi dengan nilai sebesar 0,564 atau 56%. Hal ini sejalan dengan asumsi dari teori cognitive response yaitu bagaimana konsumen memproses informasi dari iklan dan bagaimana respon kognitif ini mempengaruhi sikap dan keputusan pembelian mereka. Respon kognitif konsumen didapat melalui pemikiran konsumen tentang produk, pemikiran konsumen pada sumber informasi dan pemikiran konsumen terhadap terpaan iklan. Faktor tersebut akan mengarah pada pembentukan sikap, baik sikap pada merek dan sikap pada iklan, dengan tahapan akhir adalah keputusan pembelian. Temuan dalam artikel ini memberikan implikasi praktis bagi pelaku bisnis e-commerce agar fokus pada peningkatan kualitas konten dan interaksi antara pelaku bisnis ketika live streaming sedang berlangsung.
Common for COVID-19 cytokine storm in patients with SARS-CoV-2 infection and CLL (chronic lymphocytic leukemia)
Authors: Kobakova Yozlem , Moneva-Sakelarieva Maria , Konstantinov Spiro , Momekov Georgi , Semerdzhieva Niya Emilova , Ivanova Stefka Аchkova , Atanasova Ventseslava Petrova , Atanasov Petar Yordanov , Vakrilova Becheva Maria Stamova 
Published: September 2024

The cytokine storm has been identified as one of the leading causes of the severe course and, in some cases, the fatal outcome of COVID-19 infection. Other factors aggravating the course of the disease are accompanying disorders such as cardiovascular diseases, diabetes mellitus, diseases of the respiratory system, and oncological diseases. In this article, we present the course of the coronavirus infection in patients with an accompanying malignant disease, chronic lymphocytic leukemia (CLL), namely. The study included 8 patients with proven PCR-positive tests for SARS-CoV2 and confirmed chronic lymphocytic leukemia as a comorbidity. The course of the coronavirus infection in the CLL group was compared with that in the control group of 100 patients. In both groups, we compared subjective complaints such as tiredness, fatigue, and joint and muscle pain with objective criteria such as temperature, laboratory markers of inflammation, X-ray imaging, and frequency of necessary intubation.
Despite the expected poor prognosis in patients with concomitant oncological disease, in the case of chronic lymphocytic leukemia, our results showed a quite different milder coronavirus infection course. Obviously, patients with CLL cannot develop a pronounced cytokine storm, most probably due to certain immunosuppression related to the pathogenesis and drug treatment options for the comorbidity of CLL.