bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Rare Guillain-Barré syndrome variants and mild encephalitis/encephalopathy with a reversible splenial lesion as the para-infectious manifestations of SARS-CoV-2 infection
Authors: Si Wei , Li Yuanrui , Du Ganqin 
Published: October 2024

BackgroundThe Coronavirus disease 19 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a threat to human health. Although the COVID-19 pandemic is finished, some peoples are still suffering from this disease. Herein, we report the first case of SARS-CoV-2-associated Guillain-Barré syndrome (GBS) presenting as polyneuritis cranialis (PNC) and acute panautonomic neuropathy (APN) variants, accompanied by mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and hyponatremia.Case presentationA 32-year-old female patient with symptoms indicating multiple cranial nerve involvement, as well as sympathetic and parasympathetic nervous system dysfunction, was diagnosed as SARS-CoV-2-associated GBS presenting as PNC and APN variants, accompanied by MERS and hyponatremia. Following treatment with immunoglobulin, methylprednisolone, and symptomatic care, the patient’s inflammatory cytokines and serum sodium became normal. However, some residual symptoms such as postural hypotension, fatigue, and mild dysarthria persisted at the 9-month follow-up.ConclusionThis case highlights the unique presentation of SARS-CoV-2 infection. The involvement of both the central nervous system (CNS) and the peripheral nervous system (PNS) in this case underscores the complex neurological manifestations of COVID-19. Although the exact underlying pathogenesis of this case is unclear, inflammatory cytokines, particularly IL-6, may be implicated. Further research is needed to better understand the mechanisms underlying these complications and to optimize treatment strategies for affected patients.
Exploring the therapeutic potential of “Tianyu” medicine pair in rheumatoid arthritis: an integrated study combining LC-MS/MS, bioinformatics, network pharmacology, and experimental validation
Authors: Tang Lu , Guo Dingyuan , Jia Dongye , Piao Songlan , Fang Chunqiu , Zhu Yueya , Wang Yinghang , Pan Zhi 
Published: October 2024

BackgroundRheumatoid arthritis (RA) is a widespread chronic autoimmune disease that primarily causes joint inflammation and damage. In advanced stages, RA can result in joint deformities and loss of function, severely impacting patients’ quality of life. The “Tianyu” pair (TYP) is a traditional Chinese medicine formulation developed from clinical experience and has shown some effectiveness in treating RA. However, its role in the complex biological mechanisms underlying RA remains unclear and warrants further investigation.MethodsWe obtained gene sequencing data of synovial tissues from both RA patients and healthy individuals using two gene microarrays, GSE77298 and GSE55235, from the GEO database. Through an integrated approach involving bioinformatics, machine learning, and network pharmacology, we identified the core molecular targets of the “Tianyu” medicine pair (TYP) for RA treatment. Liquid chromatography-mass spectrometry was then employed to analyze the chemical components of TYP. To validate our findings, we conducted animal experiments with Wistar rats, comparing histopathological and key gene expression changes before and after TYP treatment.ResultsOur data analysis suggests that the onset of RA may be associated with inflammation-related immune cells involved in both adaptive and innate immune responses. Potential key targets for TYP treatment in RA include AKR1B10, MMP13, FABP4, NCF1, SPP1, COL1A1, and RASGRP1. Among the components of TYP, Kaempferol, Quercetin, and Salidroside were identified as key, with MMP13 and NCF1 showing the strongest binding affinity to these compounds. Animal experiments confirmed the findings from bioinformatics and network pharmacology, validating the key targets and therapeutic effects of TYP in treating RA.ConclusionOur study reveals that TYP has potential clinical value in the treatment of rheumatoid arthritis. This research enhances our understanding of RA’s pathogenesis and provides insight into potential therapeutic mechanisms.
Association between advanced lung cancer inflammation index and chronic kidney disease: a cross-sectional study
Authors: Li Xiaotong , Wang Qian , Wu Feng , Ye Ziyang , Li Yafeng 
Published: October 2024

BackgroundChronic kidney disease (CKD) is one of the common chronic diseases, and malnutrition and inflammation play a key role in the development of CKD. The advanced lung cancer inflammation index (ALI) is a novel index of nutrition and inflammation, and its association with CKD has not yet been clarified. The aim of this study was to explore the potential association between ALI and CKD.MethodsWe conducted a cross-sectional survey using data extracted from the National Health and Nutrition Examination Survey (NHANES, 2003–2018). Weighted multivariate logistic regression was used to assess the association between ALI and CKD, and smoothed curve fitting and threshold effect analyses were used to describe the nonlinear association between ALI and CKD. Subgroup analyses were performed to further assess the influence of other covariates on the relationship between ALI and CKD.ResultsA total of 39,469 adult participants were included in the study, of whom 7,204 (18.25%) were diagnosed with CKD. After adjusting for multiple confounders, we found a significant negative correlation between ALI and CKD (OR = 0.93; 95%CI, 0.91–0.95; p &lt; 0.0001). The risk of CKD tended to decrease with increasing quartiles of ALI. Smoothed curve fitting showed an L-shaped negative correlation between ALI and CKD. Threshold analysis showed a saturation effect of ALI at the inflection point of 55.09. Subgroup analyses and interaction tests showed that this negative association was maintained across age, sex, race, BMI, diabetes, hypertension, cardiovascular disease, and cancer subgroups (P for interaction &gt;0.05).ConclusionOur findings suggest a significant correlation between ALI and CKD in the US adult population. However, more large-scale prospective studies are still needed to further confirm our findings.
Microbiota, metabolic profiles and immune biomarkers in infants receiving formula with added bovine milk fat globule membrane: a randomized, controlled trial
Authors: Christensen Chloe , Kok Car Reen , Harris Cheryl L. , Moore Nancy , Wampler Jennifer L. , Zhuang Weihong , Wu Steven S. , Hutkins Robert , Izard Jacques , Auchtung Jennifer M. 
Published: October 2024

IntroductionFew studies have evaluated the effects of milk fat globule membrane (MFGM) on microbiota and immune markers in early infant nutrition.MethodsIn this double-blind randomized study, infants (7–18 days of age) received either bovine milk-based infant formula (Control) or similar formula with an added source (5 g/L) of bovine MFGM (INV-MFGM) for 60 days. A reference group received mother’s own human milk over the same period (HM). Oral and stool samples were collected (Baseline and Day 60) to evaluate microbiota, immune markers, and metabolites.ResultsAt Day 60, stool bacterial diversity and richness were higher in formula groups vs HM, as were Bifidobacterium bifidum and B. catenulatum abundance. Compared to HM, stool pH was higher in Control, while acetate, propionate, isovalerate, and total short- and branched-chain fatty acids were higher in INV-MFGM. Butyrate and lactate increased for INV-MFGM from baseline to Day 60. No group differences in oral microbiota or immune markers (α- and β-defensin, calprotectin, or sIgA) were detected, although sIgA increased over time in all study groups. Added bovine MFGM in infant formula modulated stool microbiota and short- and branched-chain fatty acids compared to human milk; changes were modest relative to control formula.DiscussionOverall, distinct patterns of stool metabolites and microbiota development were observed based on early nutrition.Clinical trial registrationClinicalTrials.gov, identifier NCT04059666.
Soil water uptake from different depths of three tree species indicated by hydrogen and oxygen stable isotopes in the permafrost region of Northeast China
Authors: Li Biao , Wu Xiaodong , Dong Xingfeng , Man Haoran , Liu Chao , Zou Siyuan , He Jianxiang , Zang Shuying 
Published: October 2024

Global warming has caused the gradual degradation of permafrost, which may affect the vegetation water uptake from different depths. However, the water utilization strategies of different vegetation species during the thawing stages of permafrost regions need further study. To elucidate these differences, we selected the permafrost region in Northeast China as study area. We analyzed the water uptake from different depths of Larix gmelinii, a deciduous coniferous tree, Pinus sylvestris var. mongolica, an evergreen tree, and Betula platyphylla, a deciduous broadleaf tree, using stable isotopes of xylem water, soil water, and precipitation from June to October 2019. The results showed that L. gmelinii primarily used shallow soil water (0-40 cm) with the highest proportion at 64.1%, B. platyphylla generally used middle soil water (40-110 cm) with the highest proportion at 55.7%, and P. sylvestris mainly used middle (40-110cm) and deep soil water (110-150 cm) with the highest proportion at 40.4% and 56.9%. The water sources from different depths exhibited more frequent changes in P. sylvestris, indicating a higher water uptake capacity from different soil depths. L. gmelinii mainly uptakes water from shallow soils, suggesting that the water uptake of this species is sensitive to permafrost degradation. This study revealed the water uptake strategies from different depths of three tree species in a permafrost region, and the results suggested that water uptake capacity of different tree species should be considered in the prediction of vegetation changes in permafrost regions under a warming climate.
Do marked discharge summaries with recommendation text boxes enhance patient safety? A nationwide survey
Authors: Mikkelsen Thorbjørn H , Nielsen Jesper B , Storsveen Maria M , Søndergaard Jens 
Published: October 2024

BackgroundDanish hospital physicians are required to mark their discharge summaries addressing whether the patient’s general practitioner (GP) is recommended to follow up as well as suggest follow-up actions.AimTo investigate whether a new form of discharge summaries may contribute to improve the perceived patient safety following transition from hospitals to general practice.Design & settingThis paper reports data from a questionnaire sent to a representative sample of GPs in Denmark.MethodA questionnaire was prepared for GPs based on background material, focus group interviews and discussions with relevant professionals. It was subsequently pilot tested by fellow researchers and GPs and revised prior to the presently reported survey.ResultsOf 310 participating GPs, 197 (63%) ‘totally agree’ or ‘partly agree’ that the marked discharge summaries with a recommendation text box contribute to a better handover to general practice, and 223 (72%) ‘totally agree’ or ‘partly agree’ that they improve patient safety.ConclusionThe majority of responding GPs believe that the marked discharge summaries with a recommendation text box enhance patient safety and facilitate the transition of care to general practice following hospital discharge.
Authors: Дьякова Юлия Рудольфовна 
Published: October 2024

Архитектурный комплекс крепости Орешек состоит из многочисленных строений разных времён, его уникальность, в том числе, и в сочетании средневековых башен с бастионами XVIII века. Известно, что бастионы Шлиссельбурга возводились по распоряжению Петра I, их строительство и облицовка камнем были закончены лишь в 1756 году, но необходимость усилить крепостную ограду бастионами осознавалась ещё в XVII веке. По мнению шведов, падение крепости под напором штурмующих войск 11 октября 1702 года явилось следствием того, что она не была укреплена по плану, предложенному Э. Дальбергом. Статья рассказывает о попытках шведов усовершенствовать древнюю русскую постройку и возвести бастионы, подробно рассматривает строительную историю, функциональные особенности и место в системе обороны капитального строения шведского периода - Королевской башни.
The architectural complex of the fortress Oreshek consists of numerous buildings of different times, its uniqueness, including the combination of medieval towers with Bastion fortifications of the XVIII century. The bastions of Shlisselburg were erected by order of Peter I, their construction and facing with stone were completed only in 1756, but the need to strengthen the fortress fence with bastions was realized in the XVII century. According to the Swedes, the fall of the fortress under the pressure of storming troops on October 11, 1702 was a consequence of the fact that it was not strengthened according to the plan proposed by E. Dahlberg. The article tells about the attempts of the Swedes to improve the ancient Russian construction and build bastions, examines in detail the construction history, functional features and place in the defense system of the capital structure of the Swedish period -the King tower.
ABOUT TREATMENT OF THE CONCEPT “CULTURAL HERITAGE” IN CONTEMPORARY HUMANITIES: THEORETIC-METHODOLOGICAL APPROACHES
Authors: Горлова Ирина Ивановна , Зорин Александр Львович 
Published: October 2024

Цель статьи представить наиболее значимые и оригинальные теоретико-методологические подходы к трактовке культурного наследия в современной гуманитаристике, проанализировать изменения содержательного наполнения данного понятия на протяжении последних десятилетий и выявить новые функции, которые культурное наследие обретает в социальной жизни людей информационной эпохи.
The goal of the article is to represent the most important and original theoretic-methodological approaches to the treatment the cultural heritage in contemporary humanities, to analyze the changes of the informative contain of this concept during last decades and reveal new functions, that cultural heritage gets in social life of information age.
TO THE PROBLEM OF THE OFFICIAL STATUS OF HISTORICAL SETTLEMENTS AND CULTURAL LANDSCAPES
Authors: Бондарь Виталий Вячеславович , Маркова Оксана Николаевна 
Published: October 2024

В статье рассматривается проблема официального статуса исторических поселений и культурных ландшафтов, составляющих особую категорию недвижимого культурного наследия, анализируются законодательно установленное понятие исторического поселения и состав его предмета охраны, в значительной мере соотносящиеся как с устоявшимися представлениями о культурном ландшафте, так и с установленными законом определениями видов объектов культурного наследия - ансамбля и достопримечательного места.
The article states the problem of the official status of historical settlements and cultural landscapes, which constitute a special category of immovable cultural heritage. The authors analyze the legally established concept of a historical settlement and the composition of its subject of protection, which are largely correlated with both settled ideas about the cultural landscape and the legal definitions of types of cultural heritage objects such as an ensemble and a place of interest.
Authors: Орфинская Ольга Вячеславовна , Шапиро Бэлла Львовна 
Published: October 2024

Царевна Наталья Алексеевна Романова скончалась 22 ноября 1728 г. в возрасте 14 лет. Местом ее погребения стал некрополь Вознесенского монастыря Московского Кремля, древняя усыпальница правящей династии. В 1929 г., при разрушении монастыря, погребение вскрыли. В нем обнаружился женский скелет в парчовом придворном платье. При натурном обследовании выяснилось, что на усопшую царевну был надет наряд из отдельных лифа и юбки со следами вторичного использования. Погребение сестры императора в этих странных одеждах противоречило как традициям Кремлевского монастыря, так и великолепию имперского погребального обряда.
Princess Natalya Alekseevna Romanova died November 22, 1728 at the age of 14 years. The place of her burial became the necropolis of the Ascension Monastery of the Moscow Kremlin, an ancient tomb of the ruling dynasty. In 1929, when the monastery destroyed, the burial opened. A woman’s skeleton in a brocade court dress found there. During a natural examination, it turned out that the deceased princess was dressed in a separate bodice and skirt with traces of recycling. The burial of the Emperor’s sister in these strange clothes contradicted both the traditions of the Kremlin monastery and the splendor of the imperial funeral ceremony.
PELATIHAN PEMBUATAN SABUN KULIT JERUK DI DESA SUNGAI GAMPA KECAMATAN RANTAU BADAUH KABUPATEN BARITO KUALA
Authors: Wardhani Raden Roro Ariessanty Alicia Kusuma , Rizkiana Fitria , Prasiska Emilda , Pardede Antoni 
Published: October 2024

Desa Sungai Gampa Kecamatan Rantau Badauh merupakan salah satu sentra jeruk siam di Kabupaten Barito Kuala. Saat ini Desa Sungai Gampa sedang giat mengembangkan produk olahan jeruk sehingga jeruk hasil panen tidak hanya dipasarkan sebagai bahan mentah tapi juga dipasarkan dalam bentuk produk olahan jeruk. Dalam proses produksi olahan jeruk, kulit buah jeruk tidak dimanfaatkan dan biasanya hanya dibuang saja. Salah satu upaya yang dapat dilakukan untuk mengurangi limbah kulit jeruk adalah dengan memanfaatkan kulit buah jeruk untuk dijadikan suatu produk yang memiliki nilai guna dan nilai ekonomis. Tujuan dari kegiatan ini adalah memperkenalkan kepada masyarakat Desa Sungai Gampa mengenai pengolahan kulit jeruk menjadi sabun. Metode yang digunakan dalam kegiatan ini adalah pemberian materi tentang alternatif produk olahan kulit jeruk dan pelatihan pembuatan sabun kulit jeruk. Â Dari kegiatan ini diharapkan masyarakat Desa Sungai Gampa dapat memanfaatkan kulit jeruk menjadi produk sabun secara mandiri.
«Two Months as the Chief of the General Staff (Sepember—October 1917)» of the General V.V. Marushevsky
Authors: Ганин А.В. 
Published: October 2024

Публикация ранее неизвестных даже специалистам воспоминаний последнего начальника Генерального штаба старой России генерала В.В. Марушевского, обнаруженных в Хорватском государственном архиве. Воспоминания написаны генералом в годы эмиграции, посвящены событиям осени 1917 г. и прежде не публиковались. В описываемый период Марушевский встречался со многими видными военными и политическими деятелями, что и зафиксировал в рукописи. Не менее важно и то, что он был очевидцем штурма Зимнего дворца 25 октября 1917 г., поскольку проживал в здании Главного штаба на Дворцовой площади Петрограда.
The publication of the memories of General V.V. Marushevsky, the last Chief of the General Staff in old Russia. Memories, discovered in the Croatian State Archives are previously unknown even to specialists. They were written by Marushevsky during the years of exile, and are dedicated to the events of autumn 1917. They contain descriptions of his meetings with prominent military and political figures and his eyewitness account of the storming of the Winter Palace on October 25, 1917, as he lived in the Main Staff building on Palace Square in Petrograd at the time.
20 años de Acta Médica Peruana
Authors: Peñaloza Rodríguez Isaías 
Published: October 2024

El editor de la revista, doctor Luis Vidal Neira, me ha invitado a escribir este editorial que que commemora los 20 años de la publicación de su primer número, lo cual agradezco y acometo con interés y la perspectiva que otorgan décadas.
PENGARUH ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) TERHADAP KEPUASAN KERJA DALAM MENINGKATKAN KINERJA PEGAWAI RUMAH SAKIT PELAMONIA MAKASSAR
Authors: Aulia Andi Besse Rezky , Ahri Reza Aril , Mahmud Nur Ulmy 
Published: October 2024

Health services are an effort to improve community welfare government priorities. Excellent health services are provided to support health improvement community as part of efforts to develop Indonesian society as a whole and as a whole. With a healthy society, people's quality of life will continue to improve, as will their resources Indonesia's human resources are able to compete with other countries. Therefore, the government provides a variety of support services to support the outlined programs and which is mandated for the successful development of public health. Behavior carried out outside of duty The main tasks carried out by officers in health facilities are usually called organizations citizenship behavior (OCB). OCB is behavior carried out by individuals that is not regulated by organization or agency and has no influence on the rewards to be obtained provide a positive impact on the company or agency if implemented well (Gunawan et al., 2019). OCB is a form of cooperation and a sense of shared responsibility to the agency or workplace. The aim of this research is to analyze the influence of influence Organizational Citizenship Behavior (OCB) on Job Satisfaction and Performance of Health Workers at PT Pelamonia Hospital Makassar. This type of research is analytical observational research with cross sectional study approach, with a sample size of 200 people, data analysis using tests multiple linear regression. The research results of the P value on the OCB variable include (Altruism, Conscientiousness, Sportsmanship, Courtesy, Civic Virtue) is smaller than the α value (0.05). There is There is no influence of OCB on job satisfaction and employee performance at Pelamonia Hospital Makassar OCB directly through satisfaction has an influence on the performance of Pelamonia Hospital employees Makassar.
اثر المنهج الاسلوبي في تنمية مهارات التذوق الادبي عند طلبة اقسام اللغة العربية في مادة الادب الحديث
Authors: م.م حسين راجح نعمة  , أ.د سعد سوادي الساعدي  
Published: October 2024

تبرز أهمية مهارات التذوق الادبي في بناء شخصية المتعلم في جميع الجوانب المعرفية والمهارية والوجدانية ، فضلا عن انها تساعد المتعلم على تحليل النصوص الادبية ، وبالتالي سعى هذا البحث الى الكشف عن تنمية هذه المهارات ، وقد استعانة الباحث بمنهج نقدي يساعد على تنميتها عند تحليل النصوص الأدبية وهو المنهج الاسلوبي ، وقد تم اتباع إجراءات المنهج التجريبي اذ اعتمد الباحث تصميما تجريبيا ذا ضبط جزئي ، وقد اختار الباحث بنحوٍ عشوائي عينة بحثه المكونة من (91) طالبًا وطالبة من كلية التربية للعلوم الإنسانية / جامعة كربلاء، بواقع (45) طالبًا وطالبةً من شعبة (ج) و(46) طالبًا وطالبةً من شعبة (أ)، ثم كافأ الباحث بين طلبة مجموعتي البحث في المتغيرات الآتية:(العمر الزمني محسوبًا بالشهور، والتحصيل الدراسي للوالدين، واختبار مهارات التذوق الادبي القبلي)، اما أداة البحث فقد اعدَّ الباحث اختباراً لقياس تنمية مهارات التذوق الادبي تألف من (40) فقرة موضوعية من نوع اختيار من متعدد ، وبعد ان عرضها على مجموعة من المحكمين في مناهج اللغة العربية وطرائق تدريسها والعلوم التربوية والنفسية، تم التثبت من صدقه وثباته، ومعامل صعوبته، وقوته التمييزية، وفعالية البدائل الخاطئة، وبعد معالجة البيانات احصائياً باستعمال مجموعة من الوسائل الإحصائية ، توصل الباحث الى وجود فرق ذو دلالة إحصائية في اختبار مهارات التذوق الادبي لصالح المجموعة التجريبية عند مستوى دلالة (0،05) وفي ضوء نتائج البحث توصل الباحث ان تفعيل دور المنهج الاسلوبي في تحليل النصوص الادبية يؤدي الى تنمية مهارات التذوق الادبي.
المثابرة التحفيزية لدى طالبات قسم رياض الاطفال
Authors: صبا خليل ابراهيم  , أ.د.  بشرى حسين علي  
Published: October 2024

يهدف البحث الحالي التعرف الى: المثابرة التحفيزية لدى طالبات قسم رياض الاطفال.
استخدمت الباحثة المنهج الوصفي الارتباطي لتحقيق أهداف البحث، وتكونت عينة البحث من (400) طالبة تم اختيارهنّ بالطريقة العشوائية البسيطة بأسلوب النسبة والتناسب من طالبات قسم رياض الأطفال في كلية التربية الأساسية في الجامعة المستنصرية. وقد استعملت الباحثة أداة مقياس المثابرة التحفيزية، وارتأت الباحثة تبني مقياس المثابرة التحفيزية ل (الددة،2021)المترجم والذي وضعه كونستانتيين واخرون (Constantin,etal,2012) ، ويتكون من (40) فقرة والمتكون من خمسة مجالات هي: (تحديد الاهداف بعيدة الأجل , والسعي الى تحقيق الاهداف بعيدة الأجل , وتخطيط المهام الحالية , وتتبع المهام الحالية , وتذكر الاهداف غير المحققة ) ,وتحققت الباحثة من الخصائص السايكومترية للمقياس من خلال الصدق الظاهري إذ قامت بعرض الفقرات على (12) خبيراً ، والصدق البنائي .وبعد تطبيق الأداة على عينة البحث وتحليل البيانات باستخدام الحقيبة الإحصائية توصلت الباحثة إلى النتائج الاتية : تتميز طالبات قسم رياض الأطفال بالمثابرة التحفيزية .