bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Survey Scales for Measuring Exposure and Behavioral Responses to Disruptive Intraoperative Behavior
Authors: Villafranca Alexander , Hamlin Colin , Rodebaugh Thomas L. , Robinson Sandra , Jacobsohn Eric 
Published: September 2017

Objectives
Disruptive intraoperative behavior has detrimental effects to clinicians, institutions, and patients. How clinicians respond to this behavior can either exacerbate or attenuate its effects. Previous investigations of disruptive behavior have used survey scales with significant limitations. The study objective was to develop appropriate scales to measure exposure and responses to disruptive behavior.

Methods
We obtained ethics approval. The scales were developed in a sequence of steps. They were pretested using expert reviews, computational linguistic analysis, and cognitive interviews. The scales were then piloted on Canadian operating room clinicians. Factor analysis was applied to half of the data set for question reduction and grouping. Item response analysis and theoretical reviews ensured that important questions were not eliminated. Internal consistency was evaluated using Cronbach α. Model fit was examined on the second half of the data set using confirmatory factor analysis. Content validity of the final scales was re-evaluated. Consistency between observed relationships and theoretical predictions was assessed. Temporal stability was evaluated on a subsample of 38 respondents.

Results
A total of 1433 and 746 clinicians completed the exposure and response scales, respectively. Content validity indices were excellent (exposure = 0.96, responses = 1.0). Internal consistency was good (exposure = 0.93, responses = 0.87). Correlations between the exposure scale and secondary measures were consistent with expectations based on theory. Temporal stability was acceptable (exposure = 0.77, responses = 0.73).

Conclusions
We have developed scales measuring exposure and responses to disruptive behavior. They generate valid and reliable scores when surveying operating room clinicians, and they overcome the limitations of previous tools. These survey scales are freely available.
Characterizing the temporal dynamics of object recognition by deep neural networks : role of depth
Authors: Ramakrishnan Kandan , Groen Iris I.A. , Smeulders Arnold W.M. , Scholte H. Steven , Ghebreab Sennay 
Published: September 2017

AbstractConvolutional neural networks (CNNs) have recently emerged as promising models of human vision based on their ability to predict hemodynamic brain responses to visual stimuli measured with functional magnetic resonance imaging (fMRI). However, the degree to which CNNs can predict temporal dynamics of visual object recognition reflected in neural measures with millisecond precision is less understood. Additionally, while deeper CNNs with higher numbers of layers perform better on automated object recognition, it is unclear if this also results into better correlation to brain responses. Here, we examined 1) to what extent CNN layers predict visual evoked responses in the human brain over time and 2) whether deeper CNNs better model brain responses. Specifically, we tested how well CNN architectures with 7 (CNN-7) and 15 (CNN-15) layers predicted electro-encephalography (EEG) responses to several thousands of natural images. Our results show that both CNN architectures correspond to EEG responses in a hierarchical spatio-temporal manner, with lower layers explaining responses early in time at electrodes overlying early visual cortex, and higher layers explaining responses later in time at electrodes overlying lateral-occipital cortex. While the explained variance of neural responses by individual layers did not differ between CNN-7 and CNN-15, combining the representations across layers resulted in improved performance of CNN-15 compared to CNN-7, but only after 150 ms after stimulus-onset. This suggests that CNN representations reflect both early (feed-forward) and late (feedback) stages of visual processing. Overall, our results show that depth of CNNs indeed plays a role in explaining time-resolved EEG responses.
Impaired conscious access and abnormal attentional amplification in schizophrenia
Authors: Berkovitch L , Del Cul A , Maheu M , Dehaene S 
Published: September 2017

AbstractPrevious research suggests that the conscious perception of a masked stimulus is impaired in schizophrenia, while unconscious bottom-up processing of the same stimulus, as assessed by subliminal priming, can be preserved. Here, we test this postulated dissociation between intact bottom-up and impaired top-down processing and evaluate its brain mechanisms using high-density recordings of event-related potentials. Sixteen patients with schizophrenia and sixteen controls were exposed to peripheral digits with various degrees of visibility, under conditions of either focused attention or distraction by another task. In the distraction condition, the brain activity evoked by masked digits was drastically reduced in both groups, but early bottom-up visual activation could still be detected and did not differ between patients and controls. By contrast, under focused top-down attention, a major impairment was observed: in patients, contrary to controls, the late non-linear ignition associated with the P3 component was reduced. Interestingly, the patients showed an essentially normal attentional amplification of the PI and N2 components. These results suggest that some but not all top-down attentional amplification processes are impaired in schizophrenia, while bottom-up processing seems to be preserved.
PDZ Domains in Microorganisms: Link Between Stress Response and Protein Synthesis
Authors: Muley Vijaykumar Yogesh , Galande Sanjeev 
Published: September 2017

AbstractThe PSD-95/Dlg-A/ZO-1 (PDZ) domain is highly expanded and diversified in metazoan where it is known to assemble diverse signalling components by virtue of interactions with other proteins in sequence-specific manner. In contrast, in bacteria it monitors protein quality control during stress response. The distribution, functions and origin of PDZ domain-containing proteins in prokaryotes are largely unknown. We analyzed 7,852 PDZ domain-containing proteins in 1,474 prokaryotes and fungi. PDZ domains are abundant in eubacteria; and, this study confirms their occurrence also in archaea and fungi. Of all eubacterial PDZ domain-containing proteins, 89% are predicted to be membrane and periplasmic, explaining the depletion of bacterial domain forms in metazoan. Planctomycetes, myxobacteria and other eubacteria occupying terrestrial and aquatic niches encode more domain copies, which may have contributed towards multi-cellularity and prokaryotic-eukaryotic transition. Over 93% of the 7,852 PDZ-containing proteins classified into 12 families including 6 novel families. Out of these 88% harbour eight different protease domains, suggesting their substrate-specificity is guided by PDZ domains. The genomic context provides tantalizing insight towards the functions associated with PDZ domains and reinforces their involvement in protein synthesis. We propose that the highly variable PDZ domain of the uncharacterized Fe-S oxidoreductase superfamily, exclusively found in gladobacteria and several anaerobes and acetogens, may have preceded all existing PDZ domains.
Evidence of population specific selection inferred from 289 genome sequences of Nilo-Saharan and Niger-Congo linguistic groups in Africa
Authors: Mulindwa Julius , Noyes Harry , Ilboudo Hamidou , Nyangiri Oscar , Koffi Mathurin , Mumba Dieudonne , Simo Gustave , Enyaru John , Chisi John , Simuunza Martin , Alibu Pius , Jamoneau Vincent , Macleod Annette , Bucheton Bruno , Hertz-Fowler Christiane , Sidibe Issa , Matovu Enock ,   for the TrypanoGEN Research Group, as members of The H3Africa Consortium.
Published: September 2017

AbstractBackgroundThere are over 2000 genetically diverse ethno-linguistic groups in Africa that could help decipher human evolutionary history and the genetic basis of phenotypic variation. We have sequenced 300 genomes from Niger-Congo populations from six sub-Saharan African countries (Uganda, Democratic Republic of Congo, Cameroon, Zambia, Ivory Coast, Guinea) and a Nilo-Saharan population from Uganda. Of these, we analysed 289 samples for population structure, genetic admixture, population history and signatures of selection. These samples were collected as part of the TrypanoGEN consortium project [1].ResultsThe population genetic structure of the 289 individuals revealed four clusters, which correlated with ethno-linguistic group and geographical latitude. These were the West African Niger-Congo A, Central African Niger-Congo B, East African Niger-Congo B and the Nilo-Saharan. We observed a spatial distribution of positive natural selection signatures in genes previously associated with AIDS, Tuberculosis, Malaria and Human African Trypanosomiasis among the TrypanoGEN samples. Having observed a marked difference between the Nilo-Saharan Lugbara and Niger-Congo populations, we identified four genes (APOBEC3G,TOP2B,CAPN9,LANCL2), which are highly differentiated between the two ethnic groups and under positive selection in the Lugbara population (_iHS -log p > 3.0, Rsb -log p > 3.0, Fst > 0.1 bonferroni p > 1.8x10e4).ConclusionThe signatures that differentiate ethnically distinct populations could provide information on the specific ecological adaptations with respect to disease history and susceptibility/resistance. For instance in this study we identifiedAPOBEC3Gwhich is believed to be involved in the susceptibility of the Nilo-Saharan Lugbara population to Hepatitis B virus infection.
Novel transcriptional activity and extensive allelic imbalance in the human MHC region
Authors: Gensterblum Elizabeth , Wu Weisheng , Sawalha Amr H 
Published: September 2017

AbstractThe major histocompatibility complex (MHC) region encodes human leukocyte antigen (HLA) genes and is the most complex region in the human genome. The extensive polymorphic nature of the HLA hinders accurate localization and functional assessment of disease risk loci within this region. Using targeted capture sequencing and constructing individualized genomes for transcriptome alignment, we identified 908 novel transcripts within the human MHC region. These include 593 novel isoforms of known genes, 137 antisense strand RNAs, 119 novel long intergenic noncoding RNAs, and 5 transcripts of 3 novel putative protein coding human endogenous retrovirus genes. We revealed extensive allele-dependent expression imbalance involving 88% of all heterozygous transcribed single nucleotide polymorphisms throughout the MHC transcriptome. Further, we showed that the transcriptome within the MHC region can be defined by 14 distinct co-expression clusters, with evidence of co-regulation by unique transcription factors in at least 9 of these clusters. Our data suggest a very complex regulatory map of the human MHC, and can help uncover functional consequences of disease risk loci in this region.
Associative memory retrieval modulates upcoming perceptual decisions
Authors: Bornstein Aaron M. , Aly Mariam , Feng Samuel F. , Turk-Browne Nicholas B. , Norman Kenneth A. , Cohen Jonathan D. 
Published: September 2017

AbstractExpectations can inform fast, accurate decisions. But what informs expectations? Here we test the hypothesis that expectations are set by dynamic inference from memory. Participants performed a cue-guided perceptual decision task with independently-varying memory and sensory evidence. Cues established expectations by reminding participants of past stimulus-stimulus pairings, which predicted the likely target in a subsequent noisy image stream. Participant’s responses used both memory and sensory information, in accordance to their relative reliability. Formal model comparison showed that the sensory inference was best explained when its parameters were set dynamically at each trial by evidence sampled from memory. Supporting this model, neural pattern analysis revealed that responses to the probe were modulated by the specific content and fidelity of memory reinstatement that occurred before the probe appeared. Together, these results suggest that perceptual decisions arise from the continuous sampling of memory and sensory evidence.
Crossmodal congruency effect scores decrease with repeat test exposure
Authors: Gill Satinder , Blustein Daniel , Wilson Adam , Sensinger Jon 
Published: September 2017

AbstractThe incorporation of feedback into a person’s body schema is well established. The crossmodal congruency effect (CCE) task is used to objectively quantify incorporation without being susceptible to experimenter biases. This visual-tactile interference task is used to calculate the CCE score as a difference in response time for incongruent and congruent trials. Here we show that this metric is susceptible to a learning effect that causes attenuation of the CCE score due to repeated task exposure sessions. We demonstrate that this learning effect is persistent, even after a 6 month hiatus in testing. Two mitigation strategies are proposed: 1. Only use CCE scores that are taken after learning has stabilized, or 2. Use a modified CCE protocol that decreases the task exposure time. We show that the modified and shortened CCE protocol, which may be required to meet time or logistical constraints in laboratory or clinical settings, reduced the impact of the learning effect on CCE results. Importantly, the CCE scores from the modified protocol were not significantly more variable than results obtained with the original protocol. This study highlights the importance of considering exposure time to the CCE task when designing experiments and suggests two mitigation strategies to improve the utility of this psychophysical assessment.
Integrative and distinctive coding of perceptual and conceptual object features in the ventral visual stream
Authors: Martin Chris B , Douglas Danielle , Newsome Rachel N , Man Louisa LY , Barense Morgan D 
Published: September 2017

AbstractA tremendous body of research in cognitive neuroscience is aimed at understanding how object concepts are represented in the human brain. However, it remains unknown whether and where the visual and abstract conceptual features that define an object concept are integrated. We addressed this issue by comparing the neural pattern similarities among object-evoked fMRI responses with behavior-based models that independently captured the visual and conceptual similarities among these stimuli. Our results revealed evidence for distinctive coding of visual features in lateral occipital cortex, and conceptual features in the temporal pole and parahippocampal cortex. By contrast, we found evidence for integrative coding of visual and conceptual object features in perirhinal cortex. The neuroanatomical specificity of this effect was highlighted by results from a searchlight analysis. Taken together, our findings suggest that perirhinal cortex uniquely supports the representation of fully-specified object concepts through the integration of their visual and conceptual features.
Organizational factors of justice and culture leading to organizational identification in merger and acquisition
Authors: Ismail Maimunah , Umar Baki Nordahlia 
Published: September 2017

PurposeThis paper aims to examine the influence of two organizational factors, namely, organizational justice and organizational culture, on organizational identification as perceived by employees following merger and acquisition (M&A) in Malaysia.Design/methodology/approachThe study, which adopts the Social Identity Theory as its theoretical foundation, was conducted among employees from selected Malaysian organizations that had undergone M&A from 2009 to 2016. Data were obtained from 302 respondents and analysed using Structural Equation Modelling procedures.FindingsThe results reveal that interactional justice and four dimensions of organizational culture contribute significantly to organizational identification, with a determination power of 61 per cent.Practical implicationsThe study offers practical insights to human resource managers in strengthening organizational identification as perceived by employees after an M&A by considering the crucial role of interactional justice and organizational culture.Originality/valueThere have been few investigations that link employees’ perceptions of organizational justice and culture with post-merger organizational identity. This study theorizes on human issues in M&A and enriches the Western literature on organizational identification by providing insights from an Asian (Malaysian) perspective.Research limitations/implicationsThe research is limited in terms of respondents who were employed in M&A organizations in the Klang Valley areas in Malaysia. The scope is also limited to an examination of two groups of organizational factors, namely, justice and culture, that lead to organizational identification. Implications to managing human resources from the perspective of organizational development are discussed.
Physician performance feedback in a Canadian academic center
Authors: Garvin Dennis , Worthington James , McGuire Shaun , Burgetz Stephanie , Forster Alan J. , Patey Andrea , Gerin-Lajoie Caroline , Turnbull Jeffrey , Roth Virginia 
Published: September 2017

Purpose
This paper aims at the implementation and early evaluation of a comprehensive, formative annual physician performance feedback process in a large academic health-care organization.

Design/methodology/approach
A mixed methods approach was used to introduce a formative feedback process to provide physicians with comprehensive feedback on performance and to support professional development. This initiative responded to organization-wide engagement surveys through which physicians identified effective performance feedback as a priority. In 2013, physicians primarily affiliated with the organization participated in a performance feedback process, and physician satisfaction and participant perceptions were explored through participant survey responses and physician leader focus groups. Training was required for physician leaders prior to conducting performance feedback discussions.

Findings
This process was completed by 98 per cent of eligible physicians, and 30 per cent completed an evaluation survey. While physicians endorsed the concept of a formative feedback process, process improvement opportunities were identified. Qualitative analysis revealed the following process improvement themes: simplify the tool, ensure leaders follow process, eliminate redundancies in data collection (through academic or licensing requirements) and provide objective quality metrics. Following physician leader training on performance feedback, 98 per cent of leaders who completed an evaluation questionnaire agreed or strongly agreed that the performance feedback process was useful and that training objectives were met.

Originality/value
This paper introduces a physician performance feedback model, leadership training approach and first-year implementation outcomes. The results of this study will be useful to health administrators and physician leaders interested in implementing physician performance feedback or improving physician engagement.
Non-linear elastic delamination of multilayered functionally graded beam
Authors: Rizov Victor 
Published: September 2017

Purpose
The purpose of this paper is to perform an analytical study of non-linear elastic delamination fracture in the multilayered functionally graded split cantilever beam (SCB) configuration. The SCB studied may have an arbitrary number of vertical layers. The material in each layer is functionally graded along the layer thickness. Also, the material properties may be different in each layer. The analytical solution derived was applied for parametric investigations in order to evaluate the effects of material properties and delamination crack location on the non-linear fracture behaviour.

Design/methodology/approach
The delamination fracture was studied in terms of the strain energy release rate. The SCB mechanical response was described by using a power-law stress-strain relation. A non-linear analytical solution for the strain energy release rate was derived by considering the SCB complementary strain energy. In order to verify the solution, an additional analysis of the strain energy release rate was developed by considering the complementary strain energy in the beam cross-sections ahead and behind the crack front.

Findings
The effects of material gradient, crack location along the beam width and non-linear material behaviour on the delamination fracture were evaluated. The analytical solution derived is useful for parametric studies of non-linear fracture in multilayered functionally graded beams.

Originality/value
Delamination fracture in the multilayered functionally graded SCB configuration was analysed with considering the non-linear material behaviour.
Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1
Authors: Ehara Yuko , Yamamoto Osamu , Kosaki Kenjiro , Yoshida Yuichi 
Published: September 2017

AbstractNeurofibromatosis 1 (NF1) is characterized by cutaneous, neurological and osseous manifestations. Most NF1 patients develop cutaneous neurofibromas. However, time‐dependent change with aging and the predilection site of cutaneous neurofibromas remain unclear. To clarify the natural course and characteristics of cutaneous neurofibromas, a retrospective study was conducted for 57 NF1 patients who were treated at the Department of Dermatology of Tottori University Hospital between January 2007 and April 2016. For each patient, we investigated the time‐dependent changes and the numbers of cutaneous neurofibromas in four body surface regions. There was a positive correlation between age and number of cutaneous neurofibromas (r = 0.75, P < 0.001). Cutaneous neurofibromas were located on the trunk (60.2%), lower limbs (16.1%), upper limbs (14.4%), and head and neck (9.2%). There was no significant relationship between each body type (e.g. obese or thin) and cutaneous neurofibromas. With respect to the year‐to‐year percentage change in cutaneous neurofibromas, the average annual rate of increase was 0.21 (range, −0.71 to 1.2). The number of cutaneous neurofibromas had increased in approximately 61% of the patients 1 year later. Our data will enable physicians to estimate the overall state of cutaneous neurofibromas in NF1 and will be useful for handling cutaneous manifestations before they become a serious condition.