bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic MET amplification occurs early in NF1-related malignant peripheral nerve sheath tumor (MPNST) progression and is a potent therapeutic target
Authors: Peacock Jacqueline D. , Pridgeon Matthew G. , Tovar Elizabeth A. , Essenburg Curt J. , Bowman Megan , Madaj Zachary , Koeman Julie , Grit Jamie , Dodd Rebecca D. , Cardona Diana M. , Chen Mark , Kirsch David G. , Maina Flavio , Dono Rosanna , Winn Mary E. , Graveel Carrie R. , Steensma Matthew R. 
Published: October 2017

AbstractMalignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly resistant sarcomas that occur in up to 13% of individuals with Neurofibromatosis Type 1 (NF1). Genomic analysis of longitudinally collected tumor samples in a case of MPNST disease progression revealed early hemizygous microdeletions inNF1andTP53, with concomitant amplifications ofMET,HGF, andEGFR. To examine the role of MET in MPNST progression, we developed mice with enhanced MET expression and NF1 ablation (NF1fl/KO;lox-stop-loxMETtg/+;Plp-creERTtg/+; referred to as NF1-MET). NF1-MET mice express a robust MPNST phenotype in the absence of additional mutations. A comparison of NF1-MET MPSNTs with MPNSTs derived from NF1KO/+;p53R172H;Plp-creERTtg/+(NF1-P53) and NF1KO/+;Plp-creERTtg/+(NF1) mice revealed unique Met, Ras, and PI3K signaling patterns. To investigate the therapeutic potential of MET inhibition among tumorgrafts derived from the respective MPNST models, we tested the highly selective MET inhibitor, capmatinib. NF1-MET MPNSTs were uniformly sensitive to MET inhibition whereas only a small subset of NF1-P53 and NF1 MPNSTs were inhibited. These results confirm that MET activation is sufficient for Schwann cell dedifferentiation into MPNSTs in the context of NF1 deficiency. RAS-MET signal interactions may be an important driver of MPSNT disease progression.
Haystack: systematic analysis of the variation of epigenetic states and cell-type specific regulatory elements
Authors: Pinello Luca , Farouni Rick , Yuan Guo-Cheng 
Published: October 2017

AbstractMotivationWith the increasing amount of genomic and epigenomic data in the public domain, a pressing challenge is how to integrate these data to investigate the role of epigenetic mechanisms in regulating gene expression and maintenance of cell-identity. To this end, we have implemented a computational pipeline to systematically study epigenetic variability and uncover regulatory DNA sequences that play a role in gene regulation.ResultsHaystack is a bioinformatics pipeline to characterize hotspots of epigenetic variability across different cell-types as well as cell-type specific cis-regulatory elements along with their corresponding transcription factors. Our approach is generally applicable to any epigenetic mark and provides an important tool to investigate cell-type identity and the mechanisms underlying epigenetic switches during development. Additionally, we make available a set of precomputed tracks for a number of epigenetic marks across several cell types. These precomputed results may be used as an independent resource for functional annotation of the human genome.AvailabilityThe Haystack pipeline is implemented as an open-source, multiplatform, Python package called haystack_bio available athttps://github.com/pinellolab/haystack_bio.Contactlpinello@mgh.harvard.edu,gcyuan@jimmy.harvard.edu
Influence of social capital on customer’s relationship satisfaction in the Pakistani banking industry
Authors: Muhammad Lakhi , Mahadi Batiah , Hussin Nazimah 
Published: October 2017

Purpose
The purpose of this paper is to investigate the effects of structural social capital, relational social capital and cognitive social on relationship satisfaction, and also to investigate how relationship satisfaction is associated with negative word-of-mouth and re-patronage intentions, in service recovery.

Design/methodology/approach
A sample of 478 Pakistani banking industry clients, who registered a complaint to their bank recently, answered the survey. Variance-based partial least squares structural equation modeling was employed for data analysis.

Findings
Results demonstrate that all three facets of social capital have a significant positive impact on relationship satisfaction. However, relationship satisfaction enhances customer re-patronage intentions and restrains negative word-of-mouth intentions.

Practical implications
Findings are important for service firms, particularly for banks to adjust their service recovery strategies.

Originality/value
The paper verified the influence of structural social capital, cognitive social capital and relational social capital on relationship satisfaction and tested the influence of relationship satisfaction on negative word-of-mouth and re-patronage intentions.
A study of the Chinese consumers’ product-country image of Spain
Authors: Gorostidi-Martinez Haritz , Xu Weimin , Zhao Xiaokang 
Published: October 2017

PurposeAs part of a cross-cultural research, the purpose of this paper is to provide further insights into the existing product-country image (PCI) of the Chinese consumers’ perceptions of Spain, its products, and its people, thereby providing an overall contemporary Spanish PCI within the Chinese market.Design/methodology/approachIn total, 215 valid structured questionnaires were gathered throughout China. Following a pre-investigation of 259 usable questionnaires, a 52-item construct was drawn from the existing widely used PCI item scales, designing a structured PCI construct, covering: “country image,” “personal image,” “product image,” “general knowledge about Spain,” and “personal data.”FindingsThe study provides: a PCI pre-investigation research results as well as a literature review on PCI topic; research results for the five hypotheses concerning Chinese citizens’ view of Spanish product price, quality, technicality, inventiveness, and known brands view; descriptive statistics as well as result graphs for each of the covered PCI sections; our PCI construct variable correlations with the tested five product image variables; and general implications.Research limitations/implicationsStandardizing PCI longitudinal studies, as well as focusing on how the Spanish Government and private sector should determine the long-term criteria to facilitate a clearer representation of the Spanish PCI evolution within the Chinese market, is advised.Originality/valueThe current study intends to capture insights for Spain and other country’s public and private sector decision makers to better integrate market and non-market strategies. The results would further assist delineating strategies to avoid the liability of foreignness of Spanish organizations within China.
Escalation of commitment and information security: theories and implications
Authors: Chulkov Dmitriy V. 
Published: October 2017

PurposeThis study aims to explore the challenges that the escalation of commitment poses to information security.Design/methodology/approachTwo distinct scenarios of escalation behavior are presented based on literature review. Psychological, organizational and economic theories on escalation of commitment are reviewed and applied to the area of information security.FindingsEscalation of commitment involves continuation of a course of action after receiving negative information about it. In the information security compliance context, escalation affects a firm when an employee decides to break the firm’s information security policy to complete a failing task. In the information security investment context, escalation occurs if a manager continues investment in policies and solutions that are ineffective because of psychological, organizational or economic factors. Both of these types of escalation may be prevented with de-escalation techniques including a change in management or rotation of duties, monitoring, auditing and governance mechanisms.Practical implicationsImplications of escalation of commitment behavior for information security decision-makers and for future research are discussed.Originality/valueThis study complements the literature by establishing the context of escalation of commitment in decisions related to information security and reviewing managerial and economic theories on escalation of commitment.
Incorporating privacy in the design of cloud-based systems: a conceptual meta-model
Authors: Kalloniatis Christos 
Published: October 2017

Purpose
The purpose of this paper is to extend PriS (privacy safeguard), a privacy requirements engineering method for eliciting and modelling privacy requirements during system design, with the addition of privacy-aware cloud-based concepts to assist analysts to reason and model about privacy in cloud environments.

Design/methodology/approach
An analysis of previous findings on the file of cloud privacy based on previous work has been conducted and a set of privacy-related concepts that need to be considered during privacy analysis for cloud-based systems have been revealed. These concepts were used for extending the conceptual model of PriS.

Findings
The main finding of the paper is the design of a new, novel conceptual model that assists analysts and designers in reasoning about privacy in cloud environments. A new template using the JSON (Javascript notation object) format has been introduced for better expressing the privacy requirements along with the related concepts presented through the conceptual model, thus letting the developers to better understand the findings during the design stage and better guide them to the implementation of the respective solution.

Research limitations/implications
The design of a cloud-based process that will guide analysts in detail for eliciting and modelling the identified privacy-related requirements is the limitation and in parallel the next step of the specific work presented here.

Practical implications
The conceptual model has been applied on a real case scenario regarding its efficiency on capturing and mapping all necessary concepts for assisting analysts proceed with the design of the privacy-aware system. The results were positive, all concepts were easy to use and totally understandable from the design team and the stakeholders and the use of the JSON template received very positive comments, especially from the developer’s team.

Originality/value
The paper presents a novel conceptual model for reasoning about privacy requirements in the cloud. The applicability of the proposed model has also been tested on a real case study.
To cloud or not to cloud: how risks and threats are affecting cloud adoption decisions
Authors: Kajiyama Takahiko , Jennex Murray , Addo Theophilus 
Published: October 2017

Purpose
This paper aims to discover factors that are truly affecting cloud adoption decisions in organizations. Many reasons have been given for the adoption, or lack thereof, of the cloud.

Design/methodology/approach
The paper uses an empirical approach by means of an exploratory survey, using descriptive statistics and t-tests to determine significant differences among various response groups.

Findings
The findings reveal that current and prospective cloud users feel that public cloud computing is less secure than on premise systems. These users feel that the public cloud may still be currently too immature for mission-critical system deployments; however, they do expect it to be more secure in the future as the service models become more mature and better technologies become available. None of the cloud adoption risk factors were universally considered to be showstoppers with respect to adoption.

Research limitations/implications
The sample size is relatively small compared to the number of cloud participants. Additionally, respondents were concentrated in the high technology industries in Southern California.

Originality/value
The paper provides some valuable insight into cloud adoption and concludes that despite hyped security fears, the risks and threats of the cloud are well understood and that with proper planning and implementation, organizations can adopt cloud technologies with no additional risk.
Understanding of e-service security dimensions and its effect on quality and intention to use
Authors: Taherdoost Hamed 
Published: October 2017

Purpose
Security has been a critical matter in the development of electronic services. The purpose of this research is to develop a new model to help e-service practitioners and researchers in the evaluation of e-service security and its effect on quality and intention to use e-services.

Design/methodology/approach
According to the literature, 13 security dimensions are extracted. Then, exploratory factor analysis is applied to reduce the number of security dimensions. This step is implemented based on end-users’ perception. Afterward, a hierarchical structure of e-service security is established to calculate the weights of security dimensions applying analytical hierarchy process method by contribution of e-service experts and providers. Finally, structural equation modeling using LISREL is applied to test the proposed theoretical model.

Findings
Results indicates that confidentiality, integrity, privacy, authentication, non-repudiation and availability are antecedents of consumers’ perceived security in e-service. Considering the high significance of perceived security, it is concluded that enhanced feelings of security will result in improved perception of quality. Furthermore, it is found that users will intend to use e-service if they feel that the quality of e-service is high.

Originality/value
Few studies have been done on users’ adoption behaviors of e-services and even those few have not investigated users’ security perception as a major factor affecting users’ intention to use e-services. Considering the increasing concerns of users about the security of their personal information and how it affects their adoption behaviors, there is a need to conduct more studies on the factors involved in this procedure. In this study, the concept of security from both perspective of objective security and subjective security is evaluated.
Measuring attitude towards personal data for adaptive cybersecurity
Authors: Addae Joyce Hoese , Brown Michael , Sun Xu , Towey Dave , Radenkovic Milena 
Published: October 2017

PurposeThis paper presents an initial development of a personal data attitude (PDA) measurement instrument based on established psychometric principles. The aim of the research was to develop a reliable measurement scale for quantifying and comparing attitudes towards personal data that can be incorporated into cybersecurity behavioural research models. Such a scale has become necessary for understanding individuals’ attitudes towards specific sets of data, as more technologies are being designed to harvest, collate, share and analyse personal data.Design/methodology/approachAn initial set of 34 five-point Likert-style items were developed with eight subscales and administered to participants online. The data collected were subjected to exploratory and confirmatory factor analyses and MANOVA. The results are consistent with the multidimensionality of attitude theories and suggest that the adopted methodology for the study is appropriate for future research with a more representative sample.FindingsFactor analysis of 247 responses identified six constructs of individuals’ attitude towards personal data: protective behaviour, privacy concerns, cost-benefit, awareness, responsibility and security. This paper illustrates how the PDA scale can be a useful guide for information security research and design by briefly discussing the factor structure of the PDA and related results.Originality/valueThis study addresses a genuine gap in research by taking the first step towards establishing empirical evidence for dimensions underlying personal data attitudes. It also adds a significant benchmark to a growing body of literature on understanding and modelling computer users’ security behaviours.
Uncovering the service profit chain in the casino industry
Authors: Prentice Catherine , Wong IpKin Anthony , Lam Desmond 
Published: October 2017

Purpose
This paper, from a marketing and management perspective, aims to review the relevant literature germane to casino studies. The review discusses the major findings from previous studies, provides a critique and identifies research gaps for future studies. In particular, the research foci presented in this paper rest on the service profit chain (SPC) model. The review involves studies relating to the constructs of the chain model and comprises sections that are categorized based on the internal link between management and employees, interaction between casino service employees and customers and profitability link.

Design/methodology/approach
The approach used in the current study involves a systematic review of the relevant academic literature with a focus on SPC studies in the casino industry, along with critical evaluation and analysis to identify research gaps. Google Scholar, EBSCOHost, Science Direct, Emerald and other academic databases were used to search relevant studies relating to casino and gambling research streams.

Findings
The review identifies several research gaps on the basis of the SPC link. Specifically, internal service quality needs more attention from both the practice and research points of view. Casino employee research should be extended to include personal traits and characteristics that may contribute to employee performance and loyalty. In the interaction between casino service providers and gamblers, more studies should be undertaken on the efficiency and effectiveness of marketing initiatives and promotions. Externally, the paper points out that more appropriate measurement of customer loyalty and casino profitability should be explored.

Research limitations/implications
This review provides references to focusing on key competitive advantages and presents guidelines on improving business growth and profitability for casino managers. The paper also identifies research areas that future studies should attend to.

Originality/value
The paper is the first thorough literature review of gaming research on marketing and management with a focus on the SPC model. This review represents a new era of gaming research, extending the problem gambling research focus into a broader scope embracing other disciplines.
The effect of older adults’ age identity on attitude toward online travel websites and e-loyalty
Authors: Kim Joonhyeong Joseph , Ahn Young-joo , Kim Insin 
Published: October 2017

Purpose
This study aims to identify the effect of age identity on attitude to online sites, examine the impact of this attitude on e-loyalty and investigate the moderating effect of motivational orientation.

Design/methodology/approach
A survey was distributed to an online panel consisting of US-based adults older than 50 and usable data were collected from 284 participants, followed by an analysis using structural equation modeling.

Findings
Psychological and social age negatively influenced older adults’ attitude toward travel websites. Recreation-oriented motivation influenced the effect of online attitude on e-loyalty more strongly than did task-oriented motivation.

Originality/value
Unlike previous studies, the current study provided several managerial implications for e-marketers intending to attract older adults by adopting the multidimensional scale of age identity to predict older adults’ online attitude.
In sharing economy we trust: the effects of host attributes on short-term rental purchases
Authors: Wu Jiang , Ma Panhao , Xie Karen L. 
Published: October 2017

PurposeTrust has been widely recognized as the crucial factor of consumer purchase intention when shopping on peer-to-peer short-term rental platforms where hosts and renters are strangers. However, the specific attributes of hosts that help build trust with potential renters and drive their purchase of short-term rentals remain unknown. This study aims to explore the effects of host attributes on renter purchases made on Xiaozhu.com, one of the top short-term rental platforms in China, while controlling for short-term rental characteristics.Design/methodology/approachA crawler program was developed by Python to collect the host attributes and their short-term rental characteristics of 935 hosts in Beijing from November 18, 2015 to February 14, 2016. The authors use Poisson regression models to estimate the effects of host attributes on renter reservations. They also conduct a series of robustness checks for the estimated results.FindingsThe authors found that host attributes such as the time of reservation confirmation, the acceptance rate of renter reservations, the number of listings owned, whether a personal profile page is disclosed and gender of the host significantly affect renter reservations, whereas the response rate of the host does not influence renters when purchasing short-term rentals online.Originality/valueThis study identifies which host attributes are perceived as trustworthy and affect renters’ purchase decisions, a topic of both theoretical and practical importance but currently less researched. The findings add to emerging literature by providing insights on trust-building in the peer-to-peer economy. Useful suggestions are also provided on strengthening the trust mechanism on short-term rental platforms to facilitate peer-to-peer transactions. Notably, the study is the first attempt to examine the perception of Chinese users toward short-term rentals despite its global prevalence. The analytical insights revealed from large scale but granular online observations data of host attributes and actual renter reservations greatly supplement findings of extant literature using survey and experiment approaches.
Mapping patterns of financial distress among consumers in Zimbabwe
Authors: Chamboko Richard , Kadira Gerald , Mundia Lisho , Chamboko Rumbidzai K.T. 
Published: October 2017

Purpose
The purpose of this paper is to provide a mapping of financial distress among consumers in Zimbabwe. To inform policy, it nuances the understanding of the level of financial distress and the precise location of the most distressed consumers in the country.

Design/methodology/approach
The study mapped financial distress among consumers on the ten provinces of Zimbabwe using credit repayment behavioural indicators from retail consumer loans data.

Findings
Findings showed widespread financial distress among consumers across the country with Matabeleland North and Matabeleland South provinces being the most affected, whilst Harare and Manicaland were better off. The study underscores the urgent need for an overhaul of the Zimbabwe’s haemorrhaging economy in order to restore dignity among consumers and relieve them of financial hardships.

Originality/value
The paper provides vital input for policy. Policy measures aimed at invigorating sustained economic growth, troubleshooting and revamping productivity, enhancing external competitiveness and creating employment across the country are desperately needed. Also, there is need for a functional consumer education and counselling entity to roll-out financial literacy programmes and counselling financially distressed obligors across this economically beleaguered country.