bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic insights into lethal hyper progressive disease induced by PD-L1 inhibitor in metastatic urothelial carcinoma
Authors: Nishimura Kazuki , Takahara Kiyoshi , Komura Kazumasa , Ishida Mitsuaki , Hirosuna Kensuke , Maenosono Ryoichi , Ajiro Masahiko , Sakamoto Moritoshi , Iwatsuki Kengo , Nakajima Yuki , Tsujino Takuya , Taniguchi Kohei , Tanaka Tomohito , Inamoto Teruo , Hirose Yoshinobu , Ono Fumihito , Kondo Yoichi , Yoshimi Akihide , Azuma Haruhito 
Published: September 2024

AbstractHyper progressive disease (HPD) is a paradoxical phenomenon characterized by accelerated tumor growth following treatment with immune checkpoint inhibitors. However, the pathogenic causality and its predictor remain unknown. We herein report a fatal case of HPD in a 50-year-old man with metastatic bladder cancer. He had achieved a complete response (CR) through chemoradiation therapy followed by twelve cycles of chemotherapy, maintaining CR for 24 months. Three weeks after initiating maintenance use of a PD-L1 inhibitor, avelumab, a massive amount of metastases developed, leading to the patient’s demise. Omics analysis, utilizing metastatic tissues obtained from an immediate autopsy, implied the contribution of M2 macrophages, TGF-β signaling, and interleukin-8 to HPD pathogenesis.
Democratic discrepancies in urban sustainable development
Authors: Kaufmann David , Wicki Michael , Wittwer Stefan , Stephan Jake 
Published: September 2024

AbstractCities are critical for achieving the United Nations Sustainable Development Goals. Their urban sustainable development (USD) plans and policies cover a wide range of issues, such as biodiversity protection, transportation or poverty reduction. Yet, such policy-making may lack democratic legitimacy if these policies are out of step with the demands and concerns of residents. Considering this, the present study compares residents’ preferences about USD policy issues with the priorities set out in existing USD policy plans. We scrutinized the preferences of 5,800 residents across eight European cities through the application of survey experiments and simultaneously examined 166 existing USD policy plans from these cities and compared them with the survey results. Our findings indicate an on average high acceptance of USD (72.61%) but with substantial democratic discrepancies: while USD policy plans predominantly prioritize issues, such as biodiversity, education and transportation, residents expressed preferences for issues linked to their essential and everyday needs, such as cost of living, public health and poverty. These democratic discrepancies between residents’ priorities and the content of USD policy plans highlight the necessity of securing basic human needs as integral aspects of USD to foster a more profound and democratically supported urban socio-ecological sustainability transformation.
Polymorphism of pyrene on compression to 35 GPa in a diamond anvil cell
Authors: Zhou Wenju , Yin Yuqing , Laniel Dominique , Aslandukov Andrey , Bykova Elena , Pakhomova Anna , Hanfland Michael , Poreba Tomasz , Mezouar Mohamed , Dubrovinsky Leonid , Dubrovinskaia Natalia 
Published: September 2024

AbstractStructural studies of pyrene have been limited to below 2 GPa. Here, we report on investigations of pyrene up to ~35 GPa using in situ single-crystal synchrotron X-ray diffraction in diamond anvil cells and ab initio calculations. They reveal the phase transitions from pyrene-I to pyrene-II (0.7 GPa), and to the previously unreported pyrene-IV (2.7 GPa), and pyrene-V (7.3 GPa). The structure and bonding analysis shows that gradual compression results in continuous compaction of molecular packing, eventually leading to curvature of molecules, which has never been observed before. Large organic molecules exhibit unexpectedly high conformational flexibility preserving pyrene-V up to 35 GPa. Ab initio calculations suggest that the phases we found are thermodynamically metastable compared to pyrene-III previously reported at 0.3 and 0.5 GPa. Our study contributes to the fundamental understanding of the polymorphism of polycyclic aromatic hydrocarbons and calls for further theoretical exploration of their structure–property relationships.
Ocean acidification does not prolong recovery of coral holobionts from natural thermal stress in two consecutive years
Authors: Dobson Kerri L. , Jury Christopher P. , Toonen Robert J. , McLachlan Rowan H. , Williams Jeremy C. , Grottoli Andréa G. 
Published: September 2024

AbstractUnder predicted future ocean conditions, corals will experience frequent and intense thermal stress events while simultaneously being exposed to chronic ocean acidification. Yet, some corals will likely be more resistant and/or resilient to these predicted conditions than others and may be critical to reef persistence in the future. Following natural thermal stress in two consecutive years (2014 and 2015), we evaluated the effects of feeding and simulated ocean acidification on the physiological recovery of Montipora capitata and Porites compressa sourced from Kāneʻohe Bay and Waimānalo Bay, Hawaiʻi. Following the 2014 thermal stress event, simulated ocean acidification did not slow recovery of the holobiont and feeding enhanced recovery. However, feeding did not decrease susceptibility to the 2015 thermal stress event, and simulated ocean acidification did not increase susceptibility. Recovery strategies employed between species and between sites clearly differed, highlighting that coral reef restoration and management should consider species-level and site-specific vulnerabilities. Overall, our findings call attention to the immediate threat which ocean warming presents, the lack of additional stress to the holobiont from ocean acidification, the importance of heterotrophy in coral resilience, and the potential significance of additional local biotic stressors (i.e., predator outbreaks) for coral resiliency under annual thermal stress.
The ocean carbon sink enhances countries’ inclusive wealth and reduces the cost of national climate policies
Authors: Rickels Wilfried , Meier Felix , Peterson Sonja , Rühland Sina , Thube Sneha , Karstensen Johannes , Posern Conny , Wolff Claudia , Vafeidis Athanasios T. , Grasse Patricia , Quaas Martin 
Published: September 2024

AbstractImproving our understanding of future ocean carbon uptake requires a nuanced understanding of the value of the annual ocean sink. Here, we combine an abatement cost-based approach and a climate damage-based approach to assess the value of the annual ocean sink. The former shows that the aggregate cost of national climate policies could increase by up to USD 80 billion if the ocean carbon sink weakens by 10 percent. As a complementary perspective, the damage-based approach shows that the annual ocean carbon sink contributes between USD 300 billion and USD 2,332 billion to countries’ inclusive wealth. Despite the conceptual appeal of the damage-based approach for its potential insights into regional wealth redistribution, uncertainties in national social cost of carbon estimates make it less reliable than the abatement cost-based approach, which in turn provides more reliable estimates for a fiscal cost assessment of improved monitoring services of the ocean carbon sink.
Preeminent designing of complementary ternary TRANSFER and COMPLEMENT alongside excitation modulated molecular logic systems
Authors: Karar Monaj , Fernandes Rikitha S. , Saha Snehasish , Dey Nilanjan 
Published: September 2024

This article describes an optically adjustable, dual complementary ternary molecular TRANSFER & COMPLEMENT logic gate, besides an extremely rare design of excitation-modulated logic systems on a uni-molecular platform, triggered by chemical stimuli.
Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement
Authors: Zhao Shuai , Wehrens Xander H.T. 
Published: September 2024

Abstract
Cardiac functional, morphological, and histological analysis, coupled with liquid chromatography and mass spectrometry, of two transgenic mouse models with cardiomyocyte-specific overexpression of insulin-like growth factor 1 receptor (IGF1R) or a dominant-negative PI3K mutant (DCM-dnPI3K) revealed distinctive functional and molecular profiles during physiological (driven by IGF1R overexpression) and pathological (driven by dn-PI3K overexpression) atrial remodeling. The current study confirmed previously reported findings, including ventricular dilatation and enhanced systolic function with no evidence of arrhythmia in IGF1R model, as well as ventricular hypertrophy and decreased systolic function with intermittent atrial fibrillation in DCM-dnPI3K model. Novel findings obtained from the left atrial (LA) characterization of female mice revealed that physiological atrial enlargement resulted from increased atrial myocyte size and was associated with preserved atrial function, as determined by maintained LA ejection fraction (EF). The proteomic profile of IGF1R transgenic (Tg) mice was enriched for metabolic remodeling and showed a protein expression pattern similar to that of healthy human atria; on the other hand, pathological atrial enlargement resulted from increased atrial fibrosis with normal myocyte size and was associated with impaired atrial function due to a reduced LA EF. The proteomic profile of DCM-dnPI3K mice was enriched to both metabolic and structural remodeling and showed a protein expression pattern similar to that of human AF atria
Quantification of persulfidation on specific proteins: are we nearly there yet?
Authors: Liu Hongling , Negoita Florentina , Brook Matthew , Sakamoto Kei , Morton Nicholas M. 
Published: September 2024

Abstract
Hydrogen sulfide (H2S) played a pivotal role in the early evolution of life on Earth before the predominance of atmospheric oxygen. The legacy of a persistent role for H2S in life’s processes recently emerged through its discovery in modern biochemistry as an endogenous cellular signalling modulator involved in numerous biological processes. One major mechanism through which H2S signals is protein cysteine persulfidation, an oxidative post-translational modification. In recent years, chemoproteomic technologies have been developed to allow the global scanning of protein persulfidation targets in mammalian cells and tissues, providing a powerful tool to elucidate the broader impact of altered H2S in organismal physiological health and human disease states. While hundreds of proteins were confirmed to be persulfidated by global persulfidome methodologies, the targeting of specific proteins of interest and the investigation of further mechanistic studies are still underdeveloped due to a lack of stringent specificity of the methods and the inherent instability of persulfides. This review provides an overview of the processes of endogenous H2S production, oxidation, and signalling and highlights the application and limitations of current persulfidation labelling approaches for investigation of this important evolutionarily conserved biological switch for protein function.
English Vowel Perception in Spanish–English Bilingual Preschoolers: Multiple-Talker Input Is Only Beneficial for Children With High Language Exposure Levels
Authors: Montanari Simona , Steffman Jeremy , Mayr Robert 
Published: September 2024

Purposes:
This study examines English vowel perception in Spanish–English bilingual preschoolers, comparing bilinguals' perception patterns to those of monolinguals and examining how child internal (age) and external variables (input quantity and input diversity) predict perceptual performance.

Method:
Sixty children between 3;6 and 5;6 (years;months) of age participated in the study, 28 of whom were Spanish–English bilinguals and 32 English monolinguals. Perception was assessed through a forced-choice minimal-pair identification task in which children heard synthesized audio stimuli (i.e., “sheep” and “ship”) that varied systematically along the /i–ɪ/ continuum and were asked to match them with one of two pictures. The data were analyzed with Bayesian mixed-effects logistic regression analyses, modeling responses as a function of continuum step, language background (monolingual or bilingual), age, English exposure (i.e., input quantity), and number of English input providers (i.e., input diversity).

Results:
The results indicate that, despite displaying nonnative English stop voicing perception in a previous study, the same bilingual children showed English /i–ɪ/ perception patterns that did not differ from those of monolinguals. While age did not predict vowel perception, input quantity and diversity jointly interacted to moderate how well children perceived the /i–ɪ/ contrast. Specifically, diverse input promoted perceptual performance in children who received high levels of English exposure—and who presumably had more advanced English language skills, whereas it limited perceptual performance in children with more limited English exposure and skills.

Conclusions:
This study shows that bilingual children can show monolingual-like perception patterns for some sounds while displaying nontarget perception for others. This is the first study to demonstrate that language exposure mediates the role of input diversity on speech sound development, suggesting that varied input can be more or less beneficial for speech sound development based on the learner's language learning stage.
Distributed beamforming design for UAV‐based integrated communication and jamming systems
Authors: Liu Jiteng , Ding Guoru , Xu Yitao , Wang Haichao , Gu Jiangchun 
Published: September 2024

AbstractThe integrated communication and jamming system is proposed by exploiting the diversity gain and flexible deployment of unmanned aerial vehicle (UAV)‐based distributed multiple input multiple output technology, which is expected to gain higher spectral efficiency and system scalability. This paper designs transmit beamforming of multiple UAVs so that they can simultaneously impose jamming signal to jamming targets and communication signal to communication users at the same frequency. The aim is to maximize the total jamming effect of all jamming targets while achieving a certain communication rate of communication users by optimizing the transmit beamforming matrices. Two cases are considered in which the UAV swarm works in clock synchronization and clock asynchronization. Specifically, the problem is formulated into a non‐convex optimization in the synchronous case. A near optimal solution is derived by decoupling the beamforming matrix into multi‐user interference suppression matrix and single‐user beamforming matrix. In the asynchronous case, the transmitter–receiver matching relation needs to consider and multiple optimization variables are highly coupled, penalty factors and intermediate variables to convert the optimization problem to convex programming are introduced. The simulation results show that the proposed beamforming design algorithm coordinates the communication and jamming signal rationally and outperforms the conventional beamforming design algorithms.
Recognition of vehicle license plates in highway scenes with deep fusion network and connectionist temporal classification
Authors: Hua Liru , Ma Xinyi , Zhao Chihang , Zhang Bailing , Su Zijun , Wu Yuhang 
Published: September 2024

AbstractLicense plate recognition is crucial in Intelligent Transportation Systems (ITS) for vehicle management, traffic monitoring, and security inspection. In highway scenarios, this task faces challenges such as diversity, blurriness, occlusion, and illumination variation of license plates. This article explores Recurrent Neural Networks based on Connectionist Temporal Classification (RNN‐CTC) for license plate recognition in challenging highway conditions. Four neural network models: ResNet50, ResNeXt, InceptionV3, and SENet, all combined with RNN‐CTC are comparatively evaluated. Furthermore, a novel architecture named ResNet50 Deep Fusion Network using Connectionist Temporal Classification (ResNet50‐DFN‐CTC) is proposed. Comparative and ablation experiments are conducted using the Highway License Plate Dataset of Southeast University (HLPD‐SU). Results demonstrate the superior performance of ResNet50‐DFN‐CTC in challenging highway conditions, achieving 93.158% accuracy with a processing time of 7.91 ms, outperforming other tested models. This research contributes to advancing license plate recognition technology for real‐world highway applications under adverse conditions.
RETRACTED: The Role of Customer Relationship Management to Strengthen Customer Satisfaction Using Product Innovation and Customer Value as Intervening Variable
Authors: Dananjoyo Radyan , Udin Udin , Wibowo Annisa Ayuningtyas 
Published: September 2024

The authors report an unintentional error in publishing an incorrect version of their article in ICTCED 2024 when another final version was already published online. The authors sincerely apologize for any inconvenience this careless conduct might have caused to the journal.
Request approved by the proceedings Editors and the Publisher on October 28, 2024.
Causal Relationships of Circulating Inflammatory Proteins and Portal Vein Thrombosis: A Mendelian Randomization Study
Authors: Zhang Bihui , Yao Ziping , Li Pengyu , Niu Guochen , Yan Ziguang , She Kang , Cheng Gong , Yang Min 
Published: September 2024

AbstractPortal vein thrombosis (PVT) is commonly encountered in patients with cirrhosis, challenging our understanding of its development, particularly the ambiguous contribution of inflammation. This study utilized Mendelian randomization (MR) to explore the causal impact of circulating inflammatory markers on PVT.Employing a two-sample MR framework, we merged genome-wide association study (GWAS) meta-analysis findings of 91 inflammation-associated proteins with independent PVT data from the FinnGen consortium's R10 release. A replication analysis was performed using a distinct GWAS dataset from the UK Biobank. Inverse variance weighting, MR-Egger regression, weighted median estimator, and Mendelian Randomization Pleiotropy RESidual Sum and Outlier were used for analysis, supplemented by multivariable MR (MVMR) to adjust for cirrhosis effects.Findings indicate a significant inverse association between the genetically inferred concentration of eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and PVT risk, evidenced by an odds ratio (OR) of 0.37 (95% confidence interval [CI]: 0.21–0.67; p = 9.2 × 10−4; adjusted for multiple testing p = 0.084). This association was corroborated in the replication phase (OR = 0.39, 95% CI: 0.17–0.93; p = 0.03) and through MVMR analysis (OR = 0.34, 95% CI: 0.15–0.79; p = 0.012). Sensitivity analyses disclosed no evidence of heterogeneity or pleiotropy.Our investigation emphasizes the 4E-BP1 as a protective factor against PVT, underscoring its potential relevance in understanding PVT pathogenesis and its implications for diagnosis and therapy.
Novel Nomogram for Prediction of Lymph Node Metastases from Buccal Mucosa Squamous Carcinoma Using Histological Parameters
Authors: Khunteta Nitin , Viswanath Mohinder , Mishra Akash , Samane Deepak Subhash , Vanparia Swapnil , Madhavan Abhilash , Yadav Dinesh , Sharma Sanjay , Mohan Anand , Gupta Rahul , Parikh Purvish M. , Sharma Raj Govind 
Published: September 2024

Objective The aim of the study was to construct a nomogram that is easily reproducible, accurate, and cost-effective in predicting cervical lymph nodal metastasis in buccal mucosa cancer.
Methodology Patients who underwent radical resection of a primary tumor of the buccal mucosa with neck dissection were enrolled. Clinical characteristics independently associated with lymph nodal metastasis in multivariate analyses were adopted to build the model.
Results Patients who underwent surgery (January 2021–December 2021) were included as the model development cohort (n = 127). Depth of invasion, perineural invasion, lymphovascular invasion, and the worst pattern of invasion were independent predictors of lymph nodal metastasis. The nomogram model based on these four predictors showed good discrimination accuracy in percentage prediction of lymph nodal metastasis.
Conclusion This study proposes a simple predictive model for the risk of nodal metastasis in buccal mucosa squamous cell cancer. The study has strength that, it is based on a large sample, proposed model being simple size, and based on parameters empirically supported as well as established in literature, easy to use in routine clinical practice, and cost-effective.
Bridgeless modified Cuk–SEPIC power factor correction converter for E-bicycle applications
Authors: M. Shunmathi , Fusic S. Julius , Rajesh Shanmugavel , Giri Jayant , T. Sathish , Alarifi Abdullah , Hasnain S. M. Mozammil 
Published: September 2024

The focus of this scope is on the single phase Cuk and SEPIC power factor correction converter that is attractive to electric bicycle applications. In order to guarantee improved performance, the proposed modified converter is designed to operate in discontinuous conduction mode, which is hidden by changes in supply and load voltage. For rated load, the investigational study achieves reduced input line total harmonic distortion and unity power factor. Line regulation, high efficiency, and load regulation are achieved by means of a closed loop PI control circuit that has a voltage sensor and current loop. The power supply is simulated using MATLAB/Simulink under various operating conditions, and the designed system is validated using a 250 W hardware prototype. The input current is observed to be perfectly sinusoidal, and the IEC 61000-3-2 class A standard is followed in recording the total harmonic distortion of the mains current.
Understanding Rhododendron intraspecific compatibility in botanic garden collections for species conservation
Authors: Hu Ling , Gardiner Susan E. , Tate Jennifer A. , MacKay Marion B. 
Published: September 2024

Context Controlled pollination is an important technique for maintaining intraspecific diversity in integrated plant conservation practices, particularly in genera such as Rhododendron, where open pollination usually produces hybrids with unknown paternal lineages. Aims This study investigated the capacity for viable seed set from self- and intraspecific cross-pollination for Rhododendron taxa in different categories of the International Union for Conservation of Nature (IUCN) Red List, to guide conservation management of threatened species in botanic garden collections. Methods The following five taxa of subsection Maddenia were studied: R. dalhousiae var. dalhousiae (Least Concern), R. dalhousiae var. rhabdotum (Vulnerable), R. lindleyi (Least Concern), R. nuttallii (Near Threatened), and R. excellens (Vulnerable). Controlled pollination was performed on selected garden accessions, and seed germination was tested at an alternating temperature regime of 15/25°C, 8 h photoperiod, and ~6 μmol m−2 s−1 photosynthetic photon flux density (PPFD). Key results Intraspecific compatibilities varied among different taxa and between self- and outcross treatments. X-ray images for Rhododendron seeds showed low capacity to predict seed germination. Neither X-ray scan nor fungicide (Ridomil) treatment showed any adverse impact on seed germination, which has positive implications for seed-banking and subsequent raising of Rhododendron seedlings. Conclusions Controlled intraspecific pollination can be used to maintain diversity of ex situ accessions for selected Rhododendron species. However, the zero or low compatibility demonstrated in some species, such as R. excellens, suggests that these species may require a different approach. Implications Intraspecific pollination should be evaluated for each Rhododendron species before a propagation program is initiated in ex situ conservation.