bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arbitrary quantum state engineering in three-state systems via Counterdiabatic driving
Authors: Chen Ye-Hong , Wu Qi-Cheng , Huang Bi-Hua , Song Jie , Xia Yan 
Published: December 2016

AbstractA scheme for arbitrary quantum state engineering (QSE) in three-state systems is proposed. Firstly, starting from a set of complete orthogonal time-dependent basis with undetermined coefficients, a time-dependent Hamiltonian is derived via Counterdiabatic driving for the purpose of guiding the system to attain an arbitrary target state at a predefined time. Then, on request of the assumed target states, two single-mode driving protocols and a multi-mode driving protocol are proposed as examples to discuss the validity of the QSE scheme. The result of comparison between single-mode driving and multi-mode driving shows that multi-mode driving seems to have a wider rang of application prospect because it can drive the system to an arbitrary target state from an arbitrary initial state also at a predefined time even without the use of microwave fields for the transition between the two ground states. Moreover, for the purpose of discussion in the scheme’s feasibility in practice, a polynomial ansatz as the simplest exampleis used to fix the pulses. The result shows that the pulses designed to implement the protocols are not hard to be realized in practice. At the end, QSE in higher-dimensional systems is also discussed in brief as a generalization example of the scheme.
c-MET as a Potential Therapeutic Target in Ovarian Clear Cell Carcinoma
Authors: Kim Ha-Jeong , Yoon Aera , Ryu Ji-Yoon , Cho Young-Jae , Choi Jung-Joo , Song Sang Yong , Bang Heejin , Lee Ji Soo , Cho William Chi , Choi Chel Hun , Lee Jeong-Won , Kim Byoung-Gie , Bae Duk-Soo 
Published: December 2016

AbstractIn this study, we investigated the therapeutic effects of c-MET inhibition in ovarian clear cell carcinoma (OCCC). Expression levels of c-MET in the epithelial ovarian cancers (EOCs) and normal ovarian tissues were evaluated using real-time PCR. To test the effects of c-MET inhibitors in OCCC cell lines, we performed MTT and apoptosis assays. We used Western blots to evaluate the expression of c-MET and its down-stream pathway. In vivo experiments were performed to test the effects of c-MET inhibitor on tumor growth in orthotopic mouse xenografts of OCCC cell line RMG1 and a patient-derived tumor xenograft (PDX) model of OCCC. c-MET expression was significantly greater in OCCCs compared with serous carcinomas and normal ovarian tissues (p < 0.001). In in vitro study, inhibition of c-MET using c-MET inhibitors (SU11274 or crizotinib) significantly decreased the proliferation, and increased the apoptosis of OCCC cells. SU11274 decreased expression of the p-c-MET proteins and blocked the phosphorylation of down-stream proteins Akt and Erk. Furthermore, SU11274 treatment significantly decreased the in vivo tumor weight in xenograft models of RMG1 cell and a PDX model for OCCC compared to control (p = 0.004 and p = 0.009, respectively).
Improvement in Stroke-induced Motor Dysfunction by Music-supported Therapy: A Systematic Review and Meta-analysis
Authors: Zhang Yingshi , Cai Jiayi , Zhang Yaqiong , Ren Tianshu , Zhao Mingyi , Zhao Qingchun 
Published: December 2016

AbstractTo conduct a meta-analysis of clinical trials that examined the effect of music-supported therapy on stroke-induced motor dysfunction, comprehensive literature searches of PubMed, Embase and the Cochrane Library from their inception to April 2016 were performed. A total of 10 studies (13 analyses, 358 subjects) were included; all had acceptable quality according to PEDro scale score. The baseline differences between the two groups were confirmed to be comparable. Compared with the control group, the standardized mean difference of 9-Hole Peg Test was 0.28 (−0.01, 0.57), 0.64 (0.31, 0.97) in Box and Block Test, 0.47 (0.08, 0.87) in Arm Paresis Score and 0.35 (−0.04, 0.75) in Action Research Arm Test for upper-limb motor function, 0.11 (−0.24, 0.46) in Berg Balance Scale score, 0.09 (−0.36, 0.54) in Fugl-Meyer Assessment score, 0.30 (−0.15, 0.74) in Wolf Motor Function Test, 0.30 (−0.15, 0.74) in Wolf Motor Function time, 0.65 (0.14, 1.16) in Stride length and 0.62 (0.01, 1.24) in Gait Velocity for total motor function, and 1.75 (0.94, 2.56) in Frontal Assessment Battery score for executive function. There was evidence of a positive effect of music-supported therapy, supporting its use for the treatment of stroke-induced motor dysfunction. This study was registered at PRESPERO (CRD42016037106).
Vessel wall differences between middle cerebral artery and basilar artery plaques on magnetic resonance imaging
Authors: Niu Peng-Peng , Yu Yao , Zhou Hong-Wei , Liu Yang , Luo Yun , Guo Zhen-Ni , Jin Hang , Yang Yi 
Published: December 2016

AbstractA recent study showed that posterior circulation plaques have a greater capacity for positive remodeling in a non-Asian population. We aimed to investigate if the features of plaques in the middle cerebral artery (MCA) were different from those in the basilar artery (BA) in a northern Chinese population. We retrospectively analysed the records of 71 consecutive patients with acute ischemic stroke. All patients had at least one MCA or BA plaque with early or mild (<50% stenosis) atherosclerosis identified using vessel wall magnetic resonance imaging. The remodeling ratio, eccentricity index, and plaque range were compared between MCA and BA plaques using multilevel analysis. A total of 101 plaques were included. There were 70 plaques located in the MCA and 31 plaques located in the BA. The features of non-advanced atherosclerotic plaques did not differ between the MCA and BA when accounting for the degree of stenosis or plaque burden in a northern Chinese population. Symptomatic plaques were associated with a higher eccentricity index and smaller plaque range than asymptomatic plaques under the same plaque burden. Further studies are warranted to investigate the progression of atherosclerosis in different intracranial arteries.
Fractionation for further conversion: from raw corn stover to lactic acid
Authors: He Ting , Jiang Zhicheng , Wu Ping , Yi Jian , Li Jianmei , Hu Changwei 
Published: December 2016

AbstractFractionation is considered to be one promising strategy to utilize raw biomass to its fullest and produce chemicals with high selectivity. Herein, ethanol/H2O (1/1, v/v) co-solvent with 0.050 M oxalic acid is used to simultaneously fractionate 88.0 wt% of hemicellulose and 89.2 wt% of lignin in corn stover, while cellulose is not obviously degraded. H2O dissolves hemicellulose, G unit and those with β-O-4 linkage of lignin; whereas ethanol extracts G and S units as well as the skeleton with β-5 and β-β linkages of lignin. Oxalic acid effectively catalyzes the hydrolysis of hemicellulose and breaks the intermolecular linkages between hemicellulose and lignin, therefore further promotes the release of lignin. The dissolved hemicelluloses derivatives are reprocessed to produce lactic acid obtaining a high yield of 79.6 wt% with 90% selectivity by the catalysis of MgO. The remained cellulose and recovered lignin can be used further as feedstock to produce chemicals.
Kernohan-Woltman Notch Phenomenon—Case Report
Authors: Pereira Carlos 
Published: December 2016

AbstractThe Kernohan-Woltman notch phenomenon is a paradoxical neurological manifestation consisting of a motor deficit ipsilateral to a primary brain injury. It has been observed in patients with brain tumors and with supratentorial hematomas. It is considered a false localizing neurological sign. Magnetic resonance imaging (MRI) scan has been the test of choice. The recognition of this phenomenon is important to prevent a surgical procedure on the opposite side of the lesion. The present case report describes a case of chronic subdural hematoma with a probable finding of the Kernohan-Woltman phenomenon, and it discusses its pathophysiology, imaging findings, treatment, and prognosis.
QCEWAS: automated quality control of results of epigenome-wide association studies
Authors: Van der Most Peter J , Küpers Leanne K , Snieder Harold , Nolte Ilja 
Published: December 2016

Abstract

Summary
The increasing popularity of epigenome-wide association studies (EWAS) has led to the establishment of several large international meta-analysis consortia. However, when using data originating from multiple sources, a thorough and centralized quality control is essential. To facilitate this, we developed the QCEWAS R package. QCEWAS enables automated quality control of results files of EWAS. QCEWAS produces cohort-specific statistics and graphs to interpret the quality of the results files, graphs comparing results of multiple cohorts, as well as cleaned input files ready for meta-analysis.

Availability and Implementation
https://cran.r-project.org/web/packages/QCEWAS
Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
Authors: Cinelli Mattia , Sun , Yuxin , Best Katharine , Heather James M , Reich-Zeliger Shlomit , Shifrut Eric , Friedman Nir , Shawe-Taylor John , Chain Benny 
Published: December 2016

Abstract

Motivation
Somatic DNA recombination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast diversity of antigen receptor sequences. How this diversity captures antigen specificity remains incompletely understood. In this study we use high throughput sequencing to compare the global changes in T cell receptor β chain complementarity determining region 3 (CDR3β) sequences following immunization with ovalbumin administered with complete Freund’s adjuvant (CFA) or CFA alone.

Results
The CDR3β sequences were deconstructed into short stretches of overlapping contiguous amino acids. The motifs were ranked according to a one-dimensional Bayesian classifier score comparing their frequency in the repertoires of the two immunization classes. The top ranking motifs were selected and used to create feature vectors which were used to train a support vector machine. The support vector machine achieved high classification scores in a leave-one-out validation test reaching &gt;90% in some cases.

Summary
The study describes a novel two-stage classification strategy combining a one-dimensional Bayesian classifier with a support vector machine. Using this approach we demonstrate that the frequency of a small number of linear motifs three amino acids in length can accurately identify a CD4 T cell response to ovalbumin against a background response to the complex mixture of antigens which characterize Complete Freund’s Adjuvant.

Availability and implementation
The sequence data is available at www.ncbi.nlm.nih.gov/sra/?term¼SRP075893. The Decombinator package is available at github.com/innate2adaptive/Decombinator. The R package e1071 is available at the CRAN repository https://cran.r-project.org/web/packages/e1071/index.html.

Supplementary information
Supplementary data are available at Bioinformatics online.
Cerebellar anodal tDCS increases implicit visuomotor remapping when strategic re-aiming is suppressed
Authors: Leow Li-Ann , Marinovic Welber , Riek Stephan , Carroll Timothy J 
Published: December 2016

AbstractThe cerebellum is known to be critically involved in sensorimotor adaptation. Changes in cerebellar function alter behaviour when compensating for sensorimotor perturbations, as shown by non-invasive stimulation of the cerebellum and studies involving patients with cerebellar degeneration. It is known, 24 however, that behavioural responses to sensorimotor perturbations reflect both explicit processes (such as volitional aiming to one side of a target to counteract a rotation of visual feedback) and implicit, error-driven updating of sensorimotor maps. The contribution of the cerebellum to these explicit and implicit processes remains unclear. Here, we examined the role of the cerebellum in sensorimotor adaptation to a 30° rotation of visual feedback of hand position during target-reaching, when the capacity to use explicit processes was manipulated by controlling movement preparation times. Explicit re-aiming was suppressed in one condition by requiring subjects to initiate their movements within 300ms of target presentation, and permitted in another condition by requiring subjects to wait approximately 1050ms after target presentation before movement initiation. Similar to previous work, applying anodal transcranial direct current stimulation (tDCS; 1.5mA) to the right cerebellum during adaptation resulted in faster compensation for errors imposed by the rotation. After exposure to the rotation, we evaluated implicit remapping in no-feedback trials after providing participants with explicit knowledge that the rotation had been removed. Crucially, movements were more adapted in these no-feedback trials following cerebellar anodal tDCS than after sham stimulation in both long and short preparation groups. This suggests that cerebellar anodal tDCS increased implicit remapping during sensorimotor adaptation irrespective of preparation time constraints. This work shows that the cerebellum is critical in the formation of new visuomotor maps that correct perturbations in sensory feedback, both when explicit processes are suppressed and when allowed during sensorimotor adaptation.
Zebrafish Nanog is not required in embryonic cells
Authors: Gagnon James A. , Obbad Kamal , Schier Alexander F. 
Published: December 2016

SUMMARY STATEMENTThe study ofnanogmutants reveals that Nanog is required only for extraembryonic tissue development, not in embryonic cells.ABSTRACTThe role of the zebrafish transcription factor Nanog has been controversial. It has been suggested that Nanog is primarily required for the formation of the extraembryonic yolk syncytial layer (YSL) and only indirectly regulates gene expression in embryonic cells. By contrast, a more recent study has proposed that Nanog directly regulates transcription in embryonic cells during zygotic genome activation. To clarify the roles of Nanog, we performed a detailed analysis of zebrafishnanogmutants. While zygoticnanogmutants survive to adulthood, maternal-zygotic and maternal mutants exhibit developmental arrest at the blastula stage. In the absence of Nanog, the YSL fails to form and embryonic tissue detaches from the yolk. Zygotic transcription of a subset of embryonic genes is affected innanogmutants but both the YSL and embryonic phenotype can be rescued by providingnanogmRNA in YSL precursors. Notably,nanogmutant cells transplanted into wild-type hosts proliferate and contribute to embryonic tissues from all germ layers. These results indicate that zebrafish Nanog is necessary for YSL formation but is not directly required for embryonic cell differentiation.
The interaction of orientation-specific surround suppression and visual-spatial attention
Authors: Rokem Ariel , Landau Ayelet Nina 
Published: December 2016

AbstractOrientation selective surround suppression (OSSS) is a reduction in the perceived contrast of a stimulus, which occurs when a collinear grating is placed adjacent to the stimulus. Attention affects performance on many visual tasks, and we asked whether the perceptual effects of OSSS are mitigated through the allocation of voluntary visual-spatial attention. Participants were tested in a contrast discrimination task: at the beginning of each trial, one location on the screen was cued and a subsequent contrast judgment was then more likely (70%) to be performed in that location. Replicating previous results, we found that the point of subjective equality (PSE) was elevated for a collinear, relative to an orthogonal, surround. While the PSE was similar for validly and invalidly cued trials, the just noticeable difference (JND) was larger for invalid cue trials, and for collinear, relative to orthogonal surround, suggesting that while OSSS affects both perceived contrast and sensitivity, voluntary attention affects only perceptual sensitivity. In another experiment no informative cue was provided, and attention was distributed over the entire display. In this case, JND and PSE were shifted depending on the contrast of the distractor, suggesting that OSSS is affected by the allocation of visual-spatial attention, but only under conditions of distributed attention.
Entrepreneurial CSR in the context of a regional family firm: a stakeholder analysis
Authors: Alonso Abel Duarte , Austin Ian 
Published: December 2016

PurposeThe purpose of this paper is to contribute to the extant literature of family firms and corporate social responsibility (CSR), examining the case of West’n Fresh, a regional Western Australian family firm. Moreover, in adopting stakeholder theory (ST) the firm’s involvement in and resulting benefits from CSR are investigated.Design/methodology/approachIn-depth telephone and face-to-face interviews with three members of the firm, including one of its two owners, were further complemented through onsite observations and secondary data from the firm’s website and media reports.FindingsEntrepreneurial CSR emerges as a critical element in the family firm’s business philosophy, whereby through innovative practices the ownership is able to create a balance between the firm’s financial objectives and socially responsible initiatives. In particular, the development of food products creates business opportunities while at the same time addresses the needs of different consumer groups, in particular, aged care individuals. These findings have alignments with the four theses of ST; for instance, the recognition of various stakeholder groups by the firm’s ownership, and the initiatives to improve their quality of life clearly suggest associations with normative thesis.Originality/valueAlthough the field of family entrepreneurship has grown significantly, many under-researched aspects of this discipline remain. For instance, family business research, including on CSR conducted in Western Australia, a state with a very strong economic significance, and with multiple links to the outside world is very limited.
Defining and measuring corporate social reputations
Authors: Dowling Grahame 
Published: December 2016

Purpose
The purpose of this paper is to outline a theory-based approach to defining the corporate reputation construct.

Design/methodology/approach
The approach taken is to describe how to create a well-formed nominal definition of a construct and then show how this definition is translated into an operational definition that guides the selection of an appropriate measure. New definitions of corporate social reputation and appropriate measures of this construct are provided to illustrate this framework.

Findings
The definitional framework used suggests that many measures of corporate social responsibility and reputation are under specified. Thus, the measures derived from these definitions are poorly constructed. The strengths and weaknesses of three new types of measure of corporate social reputation are reviewed.

Practical implications
For scholars the advantages of creating a well-formed definition are that it will lead to a valid measure of the construct under investigation. This will then help to better interpret what are significant findings and non-findings of empirical research.

Originality/value
This paper is an extension of the author’s previous work on defining the corporate reputation construct. Because what is meant by corporate social responsibility is contested amongst scholars this and related constructs need more precise definition and measurement. This paper offers a theory-based approach to achieve this aim.
Global responsible intergenerational leadership
Authors: Puaschunder Julia 
Published: December 2016

Purpose
Global systemic risks of climate change, overindebtedness in the aftermath of the 2008/2009 World Financial Crisis and the need for pension reform in the wake of an aging western world population, currently raise attention for intergenerational fairness. Pressing social dilemmas beyond the control of singular nation states call for corporate social activities to back governmental regulation in crisis mitigation. The purpose of this paper is to promote the idea of intergenerational equity in the corporate world.

Design/methodology/approach
Theoretical description.

Findings
In the given literature on global responsible leadership in the corporate sector and contemporary corporate social responsibility (CSR) models, intergenerational equity appears to have been neglected. While the notion of sustainability has been integrated in CSR models, intergenerational equity has hardly been touched on as for being a more legal case for codifying the triple bottom line.

Practical implications
Advocating for integrating intergenerational equity concerns in CSR models in academia and practice holds untapped advantages of economically influential corporate entities, corporate adaptability and independence from voting cycles.

Social implications
Integrating a temporal dimension in contemporary CSR helps imbuing a longer-term perspective into the corporate world alongside advancing tax ethics and global governance crises prevention.

Originality/value
Future research avenues comprise of investigating situational factors influencing intergenerational leadership in the international arena in order to advance the idea of corporations tackling the most pressing contemporary challenges of mankind.
Microbial profile of food contact surfaces in foodservice establishments
Authors: Djekic Ilija , Kuzmanovic Jelena , Andjelkovic Aleksandra , Saracevic Miroslava , Stojanovic Marija M. , Tomasevic Igor 
Published: December 2016

Purpose
The purpose of this paper is to investigate the microbial profile of food contact surfaces (FCS) in foodservice industry of Serbia.

Design/methodology/approach
The research covered 21,485 samples collected from 1,085 foodservice establishments during a period of 43 months. Results were deployed in terms of food contact materials, types of FCS and types of foodservice establishments.

Findings
Highest share of results=2 log10 CFU/cm2 were present on plastic surfaces during Autumn, while on ceramic and stainless steel surfaces highest share were observed during the Summer season. Take-away food establishments had the highest share of results=2 log10 CFU/cm2 for both stainless steel and plastic surfaces. Highest share of stainless steel surfaces with microbial load=2 log10 CFU/cm2 were cutlery, dishes and knives. Plastic dishes had the highest share of results=2 log10 CFU/cm2 while cutting boards had the majority of results between 1 log10 CFU/cm2 and 2 log10 CFU/cm2.

Research limitations/implications
Limitations of the research stem from the discussion of the nature of the FCS like porosity and other physical characteristics.

Practical implications
This research has a practical application in terms of establishing process hygiene levels depending on types of food contact materials and types of FCS and seasonal variations.

Originality/value
The findings of this study are worthy, in respect to possible correlation between seasonal variation and process hygiene requirements and can facilitate a better understanding of microbial risks associated with food preparation.