bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface–Enhanced Raman Spectroscopy Label–free Detection of DNA Complementary PolyA and PolyT Polybases on Ag/TiO2 Platform
Authors: He Lijie , Langlet Michel , Stambouli Valerie 
Published: October 2016

AbstractAn original, robust, and low cost Ag°/TiO2 platform has been used for the Surface‐Enhanced Raman Spectroscopy (SERS) detection of polyA‐NH2 and polyT complementary bases. Three procedures have been assessed to immobilize the polybases in various concentrations on the SERS platform, namely immobilization of polybases alone, immobilization of the polyA‐NH2+polyT mixture, and two‐step immobilization of the polyA‐NH2•polyT system. Derived SERS spectra have been analyzed and are discussed in terms of spectrum reproducibility, influence of polybase concentration in solution, orientation of polybases at the SERS platform surface, as well as feasibility of complementary polybase hybridization. This study allows us envisaging a simple hybridization procedure using the polyA‐NH2•polyT system and an efficient SERS detection of in situ hybridization features through intensity measurements of the adenine vibration mode at 1330 cm−1.
Three‐Component Synthesis of 3‐Aminoalkylindoles using Iron(III) Phosphate
Authors: Aghaalikhani Soheyla , Behbahani Farahnaz K. 
Published: October 2016

AbstractCatalytic synthesis of 3‐substituted indole derivatives by a one‐pot three‐component coupling reaction between aldehyde, N‐methyl aniline and indole in the presence of FePO4 is described. Aldehydes having both electron‐donating and electron‐withdrawing groups were used and resulted the desired products in high yields Simple procedure, easy work up and employing of reusable and green catalyst are advantages of this protocol.
A Molecular Lock with Hydrogen Sulfate as “Key” and Fluoride as “Hand”: Computing Based Insights on the Functioning Mechanism
Authors: Paul Suvendu , Karar Monaj , Mitra Swastika , Sher Shah Selim A. , Majumdar Tapas , Mallick Arabinda 
Published: October 2016

AbstractThe present work demonstrates a new fully regenerative, molecular machine‐like “ON‐OFF‐ON” chemosensor based on a β‐carboline molecule “OFF‐ON‐OFF” cycle. It behaves as a molecular lock that requires a hydrogen sulfate (HSO4−) ion as “key” to open the lock and a fluoride (F−) ion as “hand” that removes the key from the lock to close the lock. The reversibility and reusability of sensor for the detection of hydrogen sulfate and fluoride ions were tested for six cycles. Experimental and computational studies reveal that the proton transfer process from hydrogen sulfate (HSO4−) ion to the pyridinic nitrogen atom of norharmane leading to the formation of a hydrogen bonded ion pair (HBIP) provides the optical changes in the visible region that are advantageous for real time and on‐site application.
Novel Dioxolan Derivatives of Indole as HIV‐1 Integrase Strand Transfer Inhibitors Active Against RAL Resistant Mutant Virus
Authors: Singh Raja , Yadav Pooja , Urvashi  , Tandon Vibha 
Published: October 2016

AbstractDrugs have been discovered to treat HIV‐1 but mutation in virus causing resistance to drug, necessitates a continuous development of novel molecules. We have developed new chemical constructs that target HIV‐1 integrase (HIV‐IN) and it's mutant. We have evaluated 22 dioxolan and malonyl derivatives of indole. It was observed that C‐3 substituted dioxolan derivatives 13 c and 13 o exhibited outstanding strand transfer inhibitory activity with IC50 at 5.7 and 0.2 μM respectively. The therapeutic index of 13 o was comparable to raltegravir (RAL). Compounds 13 c and 13 o not only showed excellent antiviral activity (EC50) in wild type, a moderate activity was also observed against mutant IN i. e. G140S (4.7 and 0.2 μM) and Y143R (5.0 and 0.37 μM) respectively. The computational study suggested that these inhibitors bind centrally at the active site of integrase making a close contact with the residues in or around the active site of wild type and mutant proteins. Thus the newly synthesized dioxolan derivatives opened the possibility for development of more effective IN inhibitors exploiting the strategy mentioned in our paper.
Fabrication of a Stainless‐Steel‐Mesh‐Supported Hierarchical Fe2O3@NiCo2O4 Core‐Shell Tubular Array Anode for Lithium‐Ion Battery
Authors: Chu Qingxin , Yang Bin , Wang Wei , Tong Wenming , Wang Xiaofeng , Liu Xiaoyang , Chen Jiuhua 
Published: October 2016

AbstractCore‐shell architectures with hollow micro‐structures have exhibited many potential applications in electrochemical energy storage fields. In this study, hierarchical Fe2O3@NiCo2O4 core‐shell tubular arrays have been synthesized by a multistep chemical bath deposition method. The obtained samples have been fully characterized using powder X‐ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The results show that NiCo2O4 nanosheets have been uniformly coated on the Fe2O3 tubular array obtained by ZnO array template. When tested as an anode for lithium ion battery, the Fe2O3@NiCo2O4 tubular arrays have been found to exhibit an improved specific capacity of 587 mAh g−1 at a current density of 1000 mA g−1, good rate capability and cycling stability.
Heteroatom Promoted Cycloadditions for Graphene
Authors: Denis Pablo A. 
Published: October 2016

AbstractAlthough Diels‐Alder and [2+2] cycloadditions have been performed onto graphene, defects are required to facilitate them. We report that heteroatom doping is a novel approach to promote these reactions onto graphene, by increasing reaction energies up to five times with respect to undoped graphene. The dopants introduced define the cycloaddition product. For example, Silicon facilitates [4+2] processes while Sulfur, Nitrogen and Boron give [2+2] products.
Firm‐specific knowledge assets and employment arrangements: Evidence from CEO compensation design and CEO dismissal
Authors: Wang Heli , Zhao Shan , Chen Guoli 
Published: October 2016

Research summary: We argue that firms with greater specificity in knowledge structure need to both encourage their CEOs to stay so that they make investments with a long‐term perspective, and provide job securities to the CEOs so that they are less concerned about the risk of being dismissed. Accordingly, we found empirical evidence that specificity in firm knowledge assets is positively associated with the use of restricted stocks in CEO compensation design (indicating the effort of CEO retention) and negatively associated with CEO dismissal (indicating the job securities the firm committed to CEOs). Furthermore, firm diversification was found to mitigate the effect of firm‐specific knowledge on both CEO compensation design and CEO dismissal, as CEOs are more removed from the deployment of knowledge resources in diversified firms.Managerial summary: A firm's knowledge structure, that is, the extent to which its knowledge assets are firm‐specific versus general, has implications for both CEO compensation design and CEO dismissal. In particular, we find that a firm with a high level of firm‐specific knowledge has the incentive to retain its CEO through the use of restricted stocks in CEO compensation. Such a firm is also likely to provide job security for its CEO, leading to a lower likelihood of CEO dismissal. These arguments, however, are less likely to hold in diversified corporations as CEOs in such corporations are more removed from the deployment of knowledge assets. A key managerial implication is that CEO compensation and job security design should be made according to the nature of firm knowledge assets. Copyright © 2016 John Wiley & Sons, Ltd.
Revisiting the Anterior Rectus Sheath Repair for Incisional Hernia: A 10‐Year Experience
Authors: Hodgman Erica I. , Watson Mark J. 
Published: October 2016

AbstractBackgroundSurgeons continue to seek an incisional hernia repair technique which minimizes cost and morbidity while maximizing durability. We present a single surgeon’s experience with a technique described by N.L. Browse and J.P. Chevrel in 1979.MethodsThe Chevrel/Browse repair consists of a bilateral anterior rectus sheath release, hernia sac imbrication, bilateral rectus complex medialization, and repair reinforcement with an anterior prosthetic mesh. Data were collected on all patients who underwent herniorrhaphy between April 2003 and April 2013.ResultsA total of 123 patients underwent repair. These had undergone an average of 2.6 prior abdominal operations and 0.7 prior hernia repairs; the average defect size was 64.77 ± 86.79 cm2. Twelve patients had lateral components release in addition to release of the anterior rectus sheath to achieve midline re‐approximation with minimal tension. Synthetic mesh was used in 81 % of repairs and biologic mesh in 19 %. The most common complications were seroma formation (21 %) and incisional skin breakdown (30 %); no deaths occurred. The overall recurrence rate was 5.1 %, and 7 % for the group which had follow‐up greater than 36 months. Use of biologic mesh increased the rate of seroma formation compared with synthetic mesh (50 vs. 14 %, p < 0.001), but did not increase the rate of wound breakdown (36.3 vs. 29.6 %, p = 0.72).ConclusionThis case series describes the utilization of anterior rectus sheath release and mesh placement which is anterior to the rectus muscle. Hernia recurrence and intra‐abdominal complications are observed to be uncommon after repair using this technique. Future prospective randomized studies are warranted.
Positive serum ethanol concentration on admission to hospital as the factor predictive of treatment outcome in acute methanol poisoning
Authors: Zakharov Sergey , Nurieva Olga , Kotikova Katerina , Belacek Jaromir , Navratil Tomas , Pelclova Daniela 
Published: October 2016

Abstract
Mass methanol poisonings present a serious problem for health systems worldwide, with poor outcome associated with delayed treatment. Positive pre-hospital serum ethanol concentration may have predictive value as the prognostic factor of the treatment outcome. We studied the effect of positive serum ethanol level on admission to hospital on survival in patients treated during the Czech methanol outbreak during 2012–2014. Cross-sectional cohort study was performed in 100 hospitalized patients with confirmed methanol poisoning. Pre-hospital ethanol was administered in 42 patients (by paramedic/medical staff to 30 patients and self-administered by 12 patients before admission); 58 patients did not receive pre-hospital ethanol. Forty-two patients had detectable serum ethanol concentration on admission to hospital [median 18.3 (IQR 6.6–32.2) mmol dm−3]. Pre-hospital ethanol administration by paramedic/medical staff had a significant effect on survival without visual and CNS sequelae when adjusted for arterial blood pH on admission (OR 8.73; 95 % CI 3.57–21.34; p < 0.001). No patients receiving pre-hospital ethanol died compared with 21 not receiving (p < 0.001). Positive serum ethanol concentration on admission to hospital was a predictor for survival without health sequelae when adjusted for arterial blood pH (OR 8.10; 95 % CI 2.85–23.02; p < 0.001). The probability of visual and CNS sequelae in survivors reduced with increasing serum ethanol concentration on admission.

Graphical abstract
The Contributions of Places to Metropolitan Ethnoracial Diversity and Segregation: Decomposing Change Across Space and Time
Authors: Fowler Christopher S. , Lee Barrett A. , Matthews Stephen A. 
Published: October 2016

AbstractAlthough the trend toward greater ethnoracial diversity in the United States has been documented at a variety of geographic scales, most research tracks diversity one scale at a time. Our study bridges scales, asking how the diversity and segregation patterns of metropolitan areas are influenced by shifts in the racial/ethnic composition of their constituent places. Drawing on 1980–2010 decennial census data, we use a new visual tool to compare the distributions of place diversity for 50 U.S. metro areas over three decades. We also undertake a decomposition analysis of segregation within these areas to evaluate hypotheses about the roles of different types of places in ethnoracial change. The decomposition indicates that although principal cities continue to shape the overall diversity of metro areas, their relative impact has declined since 1980. Inner suburbs have experienced substantial increases in diversity during the same period. Places with large white majorities now contribute more to overall metropolitan diversity than in the past. In contrast, majority black and majority Hispanic places contribute less to metropolitan diversity than in the past. The complexity of the patterns we observe is underscored through an inspection of two featured metropolises: Chicago and Dallas.
Educating physicians in evidence based medicine: current practices and curricular strategies
Authors: Maggio Lauren A. 
Published: October 2016

Introduction Evidence-based medicine (EBM) is an expectation of professional healthcare and a requisite component of medical school curricula. However, upon graduation medical students’ EBM skills have been found lacking suggesting a need to examine EBM training.
Methods This PhD report presents two studies on EBM education. The first study is a literature review that describes and attempts to assess educational interventions for teaching medical students EBM. The second study presents a multi-institutional case study conducted in North America using interviews and curricular materials to identify EBM instructors’ perceptions of challenges that may impede medical students’ efforts to learn EBM.
Results The literature review analyzed 20 learning interventions from 12 countries that were presented in classrooms (75 %) and clinics (25 %). The steps of EBM were addressed to varying degrees. It was not possible to draw conclusions about the efficacy of the interventions due to lack of detailed reporting. The qualitative study identified four learning challenges: sub-optimal role models, student lack of willingness to admit uncertainty, lack of clinical context, and difficulty mastering EBM skills. To meet these challenges, participants described interventions such as integrating EBM skills with other content/courses, incorporating clinical content into EBM teaching, providing faculty development, using whole-task EBM activities, and longitudinal integration of EBM across the curriculum.
Conclusion This PhD report takes steps to describe and assess EBM learning interventions, presents student learning challenges and looks at approaches institutions take to meet them.
Nuclear but not mitochondrial‐encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease
Authors: Mastroeni Diego , Khdour Omar M. , Delvaux Elaine , Nolz Jennifer , Olsen Gary , Berchtold Nicole , Cotman Carl , Hecht Sidney M. , Coleman Paul D. 
Published: October 2016

AbstractIntroductionWe have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects.MethodsHippocampal tissues from 44 non‐AD controls (NC), 10 amnestic MCI, and 18 AD cases were analyzed on Affymetrix Hg‐U133 plus 2.0 arrays.ResultsThe microarray data revealed significant down regulation in OXPHOS genes in AD, particularly those encoded in the nucleus. In contrast, there was up regulation of the same gene(s) in MCI subjects compared to AD and ND cases. No significant differences were observed in mtDNA genes identified in the array between AD, ND, and MCI subjects except one mt‐ND6.DiscussionOur findings suggest that restoration of the expression of nuclear‐encoded OXPHOS genes in aging could be a viable strategy for blunting AD progression.
Interoceptive Awareness Moderates the Relationship Between Perceived and Physiological Genital Arousal in Women
Authors: Handy Ariel B. , Meston Cindy M. 
Published: October 2016

ABSTRACTIntroductionIn general, laboratory studies have shown low correlations between subjective (ie, self-report) and physiologic (ie, vaginal pulse amplitude) measurements of sexual arousal in women. One explanation for this presumed low concordance is that women might not be attending to their genital responses and/or might be unable to accurately perceive their genital responses.AimTo examine the extent to which women can perceive their genital arousal sensations, the role that interoceptive awareness plays in this ability, and whether interoceptive awareness influences sexual concordance in women.MethodsTwenty-six sexually functional women viewed an erotic film while their physiologic and perceived genital sexual arousal levels were measured continuously. Self-report measurements of sexual function and bodily awareness also were administered.Main Outcome MeasuresPhysiologic sexual arousal was measured with a vaginal photoplethysmograph, and perception of genital arousal was measured with an arousometer. Degree of bodily awareness was measured with the Multidimensional Assessment of Interoceptive Awareness questionnaire.ResultsWomen exhibited a significant degree of agreement between physiologic and perceived genital arousal (P &lt; .05). Interoceptive awareness was found to significantly moderate this relation (P &lt; 0.05), such that a greater degree of interoceptive awareness facilitated greater agreement between physiologic and perceived genital arousal. Interoceptive awareness also was found to facilitate greater concordance between subjective and physiologic sexual arousal (P &lt; .05).ConclusionWomen can perceive their genital response, and interoceptive awareness influences this ability and the relation between subjective and physiologic sexual arousal. Increasing bodily awareness could be a plausible route for treatment development.
Exploring the Impact of Job Insecurity on Employees’ Unethical Behavior
Authors: Lawrence Ericka R. , Kacmar K. Michele 
Published: October 2016

ABSTRACT:The multitude of corporate scandals has prompted research that examines factors that influence an individual’s engagement in unethical behavior. This article extends previous research by examining the psychological processes through which unethical behavior may occur. We develop and test a model that uses self-regulation theory to explain and predict how and under what circumstances individuals are likely to engage in unethical behavior. Results from data collected from 107 professionals at two points in time and 205 employees from various industries confirm that job insecurity increases emotional exhaustion, which subsequently impairs an employee’s ability to activate self-regulating processes to avoid engaging in unethical behavior. However, the link between job insecurity and emotional exhaustion as well as the mediated relationship between job insecurity and unethical behavior through emotional exhaustion are weaker for employees who have high adaptability and stronger for employees who are highly embedded in their organization.
Empty Promises and the Myth of Mining: Does Mining Lead to Pro-Poor Development?
Authors: MEYERSFELD Bonita 
Published: October 2016

AbstractMining operations in the Global South often worsen conditions for affected communities after the conclusion of the operations as compared to pre-mining conditions. This is regression, not progress, which is contrary to the narrative surrounding mining’s promise of economic growth. While mining certainly brings profit, this profit does not result in social and economic development of affected communities and people living in poverty. This is the ‘myth of mining’ and the objective of this article is to expose this myth, identify its failings and propose a notion of ‘equitable mining’ that could ensure a pro-poor mining industry.
Use of antidepressants in patients with depression and comorbid diabetes mellitus: a systematic review
Authors: Roopan Subethini , Larsen Erik Roj 
Published: October 2016

ObjectiveDepression may be difficult to treat and with comorbid diabetes mellitus (DM) it is an even bigger challenge. This article aims to evaluate antidepressants most suitable for patients with depression and comorbid DM.Design and methodsInitially we searched for randomised, controlled double-blind trials of treatment with antidepressants in depressed with DM but there were only a few studies and many of them were small trials. Thus, we decided to include studies that were not only randomised-controlled trials. In total, we ended up with 18 articles for our purposes.ResultsThe combination of depression and DM may be harmful as depression has a strong impact on psychosocial and medical outcomes in patients with DM. Almost all of the trials in this review showed a reduction in depressive symptoms after treatment with an antidepressant in the acute as well as during maintenance phase. It showed that depression improvement had a favourable effect on glycaemic control that was weight independent. Some studies included only subjects with minor depression or with suboptimal-controlled diabetes making it difficult to show an effect.ConclusionFrom these data, we will recommend choosing an selective serotonin reuptake inhibitor (SSRI) if possible to treat a depression among patients with diabetes. If treatment with a tricyclic antidepressant is needed, closer glycaemic monitoring is recommended. Bear in mind that there is a possible risk of hypoglycemia when using SSRIs. Agomelatine and bupropion have shown promising results, but need to be investigated in more trials.
Carboniferous ostracods from central Honshu, Japan
Authors: STOCKER C. P. , KOMATSU T. , TANAKA G. , WILLIAMS M. , SIVETER D. J. , BENNETT C. E. , WALLIS S. , OJI T. , MAEKAWA T. , OKURA M. , VANDENBROUCKE T. R. A. 
Published: October 2016

AbstractSilicified beyrichiocopid and podocopid ostracods from limestone nodules derived from the middle part of the Ichinotani Formation within the Hida Gaien Terrane of central Honshu Island, Japan, are associated with fusulinid foraminifera that indicate strata of the middle Moscovian (Pennsylvanian, Carboniferous). This is a rare record of ostracods from the Palaeozoic of Japan and the first systematic description of ostracods from the Carboniferous of the Hida Gaien Terrane. The fauna comprises six ostracod species (two new) assigned to the generaAmphissites,Kirkbya,Bairdia,AechminaandHealdia, and additional material of possible cavellinids. The numerical dominance of ornamented beyrichiocopids such asKirkbyaandAmphissites, along with smaller numbers of smooth podocopids such asBairdia, indicates an ‘Eifelian mega-assemblage’ ecotype (sensuG. Becker), that is typical of mid Palaeozoic shallow marine, high-energy environments in a fore-reef ecosystem.
New U–Pb constraints identify the end-Guadalupian and possibly end-Lopingian extinction events conceivably preserved in the passive margin of North America: implication for regional tectonics
Authors: DAVYDOV V. I. , CROWLEY J. L. , SCHMITZ M. D. , SNYDER W. S. 
Published: October 2016

AbstractThe discovery and dating of a volcanic ash bed within the upper Phosphoria Formation in SE Idaho, USA, is reported. The ash occurs 11 m below the top of the phosphatic Meade Peak Member and yielded a 206Pb/238U date of 260.57 ± 0.07 / 0.14 / 0.31 Ma, i.e. latest Capitanian, Guadalupian. The stratigraphic position of this ash near the top of the Meade Peak phosphatic Member of Phosphoria Formation indicates plausible completeness of the sedimentation within the Guadalupian–Lopingian and probably at the Permo-Triassic (P-T) transitions. The new radiometric age reveals that the regional biostratigraphy and palaeontology of Phosphoria and Park City formations requires serious reconsideration, particularly in cool water conodonts, bryozoans and brachiopods. The new age proposes that the Guadalupian–Lopingian boundary (GLB) coincides with the Meade Peak – Rex contact and consequently with the end-Guadalupian extinction event. The lack of a major unconformity at the P-T transition suggests that the effects of the Sonoma orogeny were not as extensive as has been assumed.