bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected Against High-Fat Diet Induced Metabolic Syndrome
Authors: de Quixano Beatriz Bardaji , Villena Josep A. , Aranda Miguel , Brils Gemma , Cuevas Antoni , Hespel Théana , Lekuona Haizea , Súarez Cristina , Tornavaca Olga , Meseguer Anna 
Published: November 2017

AbstractMetabolic Syndrome (MS) is reaching epidemic proportions with significant social and economical burden worldwide. Since the molecular basis of MS remains poorly defined, we investigated the impact of KAP, a kidney specific androgen-regulated gene, in the development of high fat-diet (hfd)-induced MS. Tg mice overexpressing KAP specifically in proximal tubule cells of the kidney exhibited reduced body weight and lower liver and adipose tissue weight compared to control littermates when fed a hfd. KAP Tg mice showed diminished adipocyte hypertrophy and reduced hepatic steatosis, significantly correlating with expression of relevant molecular markers and lower lipid content in liver. KAP transgenic were protected from hfd-induced insulin resistance, increased blood pressure and exhibited lower IL-6 serum levels and diminished expression of inflammatory markers in the adipose. Moreover, KAP was localized in the secretory pathway of proximal tubule cells and it is released to the extracellular media, preventing IL-6 induction and STAT-3 activation upon TNFα stimulation. We conclude that KAP, which might act as a hormone-like product in extra-renal tissues, protects Tg mice against hfd-induced MS by preventing inflammatory related events that are mediated, in part, through the IL-6 pathway.
Statistical Learning in Specific Language Impairment: A Meta-Analysis
Authors: Lammertink Imme , Boersma Paul , Wijnen Frank , Rispens Judith 
Published: November 2017

Purpose
The current meta-analysis provides a quantitative overview of published and unpublished studies on statistical learning in the auditory verbal domain in people with and without specific language impairment (SLI). The database used for the meta-analysis is accessible online and open to updates (Community-Augmented Meta-Analysis), which facilitates the accumulation and evaluation of previous and future studies on statistical learning in this domain.

Method

A systematic literature search identified 10 unique experiments examining auditory verbal statistical learning in 213 participants with SLI and 363 without SLI, aged between 6 and 19 years. Data from qualifying studies were extracted and converted to Hedges'
g
effect sizes.

Results

The overall standardized mean difference between participants with SLI and participants without SLI was 0.54, which was significantly different from 0 (
p
< .001, 95% confidence interval [0.36, 0.71]).

Conclusion
Together, the results of our meta-analysis indicate a robust difference between people with SLI and people without SLI in their detection of statistical regularities in the auditory input. The detection of statistical regularities is, on average, not as effective in people with SLI compared with people without SLI. The results of this meta-analysis are congruent with a statistical learning deficit hypothesis in SLI.

Supplemental Material

https://doi.org/10.23641/asha.5558074
DC–DC autotransformer with un‐interrupted operating capability during DC fault
Authors: Li Mengbo , Xiang Wang , Zuo Wenping , Yao Liangzhong , Lin Weixing , Wen Jinyu 
Published: November 2017

This study proposed a novel type of DC/DC converter, termed as un‐interrupted DC autotransformer (DC AUTO), which has capability to ride through various kinds of DC fault without blocking any devices. Firstly, the working principles and the corresponding design procedures of the un‐interrupted DC AUTO are illustrated. Then an effective control strategy is proposed to enable steady operation during both normal time and faulted condition. Finally, a 1000 MW ± 320 kV/ ± 640 kV test system is built on PSCAD/EMTDC platform to testify the technical feasibility of the proposed converter and the effectiveness of the proposed control strategy.
Evidence for non-axisymmetry in M 31 from wide-field
kinematics of stars and gas
Authors: Opitsch M. , Fabricius M. H. , Saglia R. P. , Bender R. , Blaña M. , Gerhard O. 
Published: November 2017

Aim. As the nearest large spiral galaxy, M 31 provides a unique opportunity to study the structure and evolutionary history of this galaxy type in great detail. Among the many observing programs aimed at M 31 are microlensing studies, which require good three-dimensional models of the stellar mass distribution. Possible non-axisymmetric structures like a bar need to be taken into account. Due to M 31’s high inclination, the bar is difficult to detect in photometry alone. Therefore, detailed kinematic measurements are needed to constrain the possible existence and position of a bar in M 31.Methods. We obtained ≈220 separate fields with the optical integral-field unit spectrograph VIRUS-W, covering the whole bulge region of M 31 and parts of the disk. We derived stellar line-of-sight velocity distributions from the stellar absorption lines, as well as velocity distributions and line fluxes of the emission lines Hβ, [O III] and [N I]. Our data supersede any previous study in terms of spatial coverage and spectral resolution.Results. We find several features that are indicative of a bar in the kinematics of the stars, we see intermediate plateaus in the velocity and the velocity dispersion, and correlation between the higher moment h3 and the velocity. The gas kinematics is highly irregular, but is consistent with non-triaxial streaming motions caused by a bar. The morphology of the gas shows a spiral pattern, with seemingly lower inclination than the stellar disk. We also look at the ionization mechanisms of the gas, which happens mostly through shocks and not through starbursts.
Open clusters
Authors: Aidelman Y. , Cidale L. S. , Zorec J. , Panei J. A. 
Published: November 2017

Context.Stellar physical properties of star clusters are poorly known and the cluster parameters are often very uncertain.Aims.Our goals are to perform a spectrophotometric study of the B star population in open clusters to derive accurate stellar parameters, search for the presence of circumstellar envelopes, and discuss the characteristics of these stars.Methods.The BCD spectrophotometric system is a powerful method to obtain stellar fundamental parameters from direct measurements of the Balmer discontinuity. To this end, we wrote the interactive code MIDE3700. The BCD parameters can also be used to infer the main properties of open clusters: distance modulus, color excess, and age. Furthermore, we inspected the Balmer discontinuity to provide evidence for the presence of circumstellar disks and identify Be star candidates. We used an additional set of high-resolution spectra in the Hαregion to confirm the Be nature of these stars.Results.We provideTeff, logg,Mv,Mbol, and spectral types for a sample of 68 stars in the field of the open clusters NGC 6087, NGC 6250, NGC 6383, and NGC 6530, as well as the cluster distances, ages, and reddening. Then, based on a sample of 230 B stars in the direction of the 11 open clusters studied along this series of three papers, we report 6 new Be stars, 4 blue straggler candidates, and 15 B-type stars (called Bdd) with a double Balmer discontinuity, which indicates the presence of circumstellar envelopes. We discuss the distribution of the fraction of B, Be, and Bdd star cluster members per spectral subtype. The majority of the Be stars are dwarfs and present a maximum at the spectral type B2-B4 in young and intermediate-age open clusters (<40 Myr). Another maximum of Be stars is observed at the spectral type B6-B8 in open clusters older than 40 Myr, where the population of Bdd stars also becomes relevant. The Bdd stars seem to be in a passive emission phase.Conclusions.Our results support previous statements that the Be phenomenon is present along the whole main sequence band and occurs in very different evolutionary states. We find clear evidence of an increase of stars with circumstellar envelopes with cluster age. The Be phenomenon reaches its maximum in clusters of intermediate age (10–40 Myr) and the number of B stars with circumstellar envelopes (Be plus Bdd stars) is also high for the older clusters (40–100 Myr).
Effects of electromagnetic stirring on fluid flow and temperature distribution in billet continuous casting mould and solidification structure of 55SiCr
Authors: An Hanghang , Bao Yanping , Wang Min , Zhao Lihua 
Published: November 2017

The optimal combination of current intensity and frequency of mould electromagnetic stirring (M-EMS) in continuous casting billet was a crucial compromise for improving inner quality of cast billet such as reduction in center segregation and porosity of medium-high carbon steel. In the present study, a decoupled three-dimensional mathematic model of electromagnetic field, fluid flow and heat transfer in continue casting billet mould with EMS has been developed, and the effects of current intensity and frequency on the system were also discussed. In addition, the industrial trials were carried out to investigate the magnetic field characteristics in the mould with M-EMS and the influence of M-EMS on the solidification structure of 55SiCr. According to the calculations and analysis, the optimal combination range of current intensity and frequency was 300–320 A and 3–4 Hz, respectively. The results showed that inner quality in as-cast billet of 55SiCr has been improved significantly with optimal parameter of 320 A and 3 Hz. For instance, central equiaxed zone increased from 19% to 33%, the center carbon segregation ratio decreased from 1.13 to 1.05 as well as center porosity has nearly disappeared.
Physical and mathematical modeling of bubbles plume behaviour in one strand tundish
Authors: Cwudziński Adam 
Published: November 2017

Moving through the liquid steel, argon bubbles intensify the chemical and thermal homogenisation processes and liquid metal refining. The present study reports the physical and mathematical modeling of bubbles behaviour in the tundish with argon injection system. The 210 litre–capacity one strand slab tundish model was made on a scale of 2:5. The laboratory water model experiments have demonstrated that the identical porous material used in gas-permeable barrier may generate gas bubbles varying in size and shape. This fact will also affect both vertical and horizontal velocities attained by the bubbles. From numerical simulations influence of argon flow rate on liquid steel velocity for free surface in the tundish was obtained. The results from numerical simulations indicate that argon create increasing of liquid steel velocity and vortex structures.
From the exclusion of the people in neoliberalism to publicity without a public
Authors: Queiroz Regina 
Published: November 2017

AbstractThis paper argues that the neoliberal political order relies on a particular concept of publicity—the concept of openness or transparency without a public (apopulusordemos), the main content of which is the unconditional maxim “There Is No Alternative” (TINA for short). Its central claim is that the neoliberal conception of publicity without a public, connected as it is to secrecy and unconditional adherence to TINA, precludes the possibility of the “people” as an ultimateintentionalsovereign legislator. Although research has revealed the strategic importance of publicity for communicative capitalism, this aspect of neoliberalism has yet to be addressed. As a means of clarifying the neoliberal concept of publicity, this paper will show that neoliberal theory cannot consistently accept the existence of the people as sovereign while maintaining its adherence to TINA. Second, it invokes the Kantian conception of publicity, which involves not merely openness and visibility but also the will of thepopulus. One of Kant’s central insights is that publicity is a necessary (but not sufficient) condition for fairness at the level of political decision-making. When public (openly accessible) statements are not based on the will of the people, publicity can become a means of illegitimate political domination against sovereign peoples. Building on Kant’s insights, this paper will show that publicity without a public, along with its central mantra, TINA, is also, at the practical level, neoliberalism’s main means of destroying the legislative sovereignty of the people. Since TINA precludes the possibility of the people as sovereign, analysis of the neoliberal conception of publicity that underlies TINA provides new arguments for the view that neoliberalism is essentially despotic in nature. It also points to the importance of the political category of “the sovereign people”, which is all the greater where illiberal and undemocratic political alternatives jockey to fill the vacuum left by a system that, at its ideological core, cannot acknowledge the common good.
Cancer cells induce interleukin-22 production from memory CD4+T cells via interleukin-1 to promote tumor growth
Authors: Voigt Cornelia , May Peter , Gottschlich Adrian , Markota Anamarija , Wenk Daniel , Gerlach Inga , Voigt Sebastian , Stathopoulos Georgios T. , Arendt Kristina A. M. , Heise Constanze , Rataj Felicitas , Janssen Klaus-Peter , Königshoff Melanie , Winter Hauke , Himsl Isabelle , Thasler Wolfgang E. , Schnurr Max , Rothenfußer Simon , Endres Stefan , Kobold Sebastian 
Published: November 2017

SignificanceIL-22 has been identified as a cancer-promoting cytokine, but its regulation in cancer tissue has not been addressed. Using both murine and human models, we demonstrate that cancer cells directly induce IL-22 production. We prove that interleukin-1β induced by inflammasome activation is critical for IL-22 production. IL-1β increased the activity of the IL-22 transcription factors in lineage-committed T cells. We show the existence of IL-22–producing Th1, Th17, and Th22 cells in tumor tissue of patients. Use of the clinically approved IL-1 receptor antagonist anakinra in vivo reduced IL-22 production and reduced tumor growth in a breast cancer model. These data provide the basis for therapeutic interventions, particularly using anakinra, aiming at limiting IL-22 production in patients with cancer.
Pilgrimages and peace-building on the global stage.
Authors: McIntosh I. S. 
Published: November 2017

Abstract

This chapter presents a survey of pilgrimages in which peace is specifically mentioned as a desired outcome or where the greater common good is prioritized. It focuses on world religions, inter-faith pilgrimages, civil and cultural religion pilgrimages in North America, pilgrimages to sites of conscience, and green pilgrimages.
Pilgrimages of transformation and reconciliation: Māori and Pākehā walking together in Aotearoa New Zealand.
Authors: Hornblow J. , Boyack J. 
Published: November 2017

Abstract

This chapter discusses the role pilgrimages play in promoting understanding and unity between the two founding peoples of Aotearoa (New Zealand): Māori (Indigenous) and Pākehā (European). It also discusses how the pilgrimage experiences of New Zealanders continue to bring them into contact with people, places and resources that have a potential to expand their collective understanding of who they are and enlarge their vision of who they might become.
'Sheaves of corn in an autumn field': the 'hungry' walk to Delphi Lodge.
Authors: Quinn E. M. 
Published: November 2017

Abstract

This chapter presents an account of a tragic episode during the Great Irish Famine, the Doolough Tragedy, and how today pilgrims retrace the steps of the victims in search of healing. The chapter examines the meaning of this human rights pilgrimage in light of historical facts and fallacies about the Famine; theories of cultural heritage commemoration; symbolic and bodily acts of remembrance; and current concerns that address food production and global hunger.
Pilgrimage, Bhaktı¯ and identity: a study of Maharashtrian Vārı¯.
Authors: Sambhus V. 
Published: November 2017

Abstract

This chapter examines a major pilgrimage in western India known as Vārī. This pilgrimage has impacted the social, political, religious and cultural life in the state of Maharashtra and beyond. One of its major outcomes is that it has democratized religion, breaking down the traditional caste system and paving the way for social and political equality. This chapter shows how the institution of pilgrimage leads to a sense of common identity by addressing four broad and interconnected themes: Hindu pilgrimage, Bhaktītradition in Maharashtra, the Vārkarī sect and the Vārī pilgrimage itself.
Circling centre, finding our way home: circumambulation pilgrimages around Iona, Mount Tamalpais and labyrinths.
Authors: Pavlinac C. 
Published: November 2017

Abstract

This chapter focuses on contemplative walking as a core pilgrimage practice. By such means, walking becomes a powerful tool in finding one's way home to what the author describes as the centre. The chapter presents an account of labyrinth walks and walking pilgrimages around Mount Tamalpais (Marin County, California, USA) and on the island of Iona (Scotland, UK).
Sacred journeys on the path of yoga: an exploration of yoga practice and philosophy.
Authors: Sonika Jain Sonika Jain 
Published: November 2017

Abstract

This chapter offers a comprehensive understanding of yoga, interweaving its personal and broader dimensions. It also highlights the learnings from the sacred journeys of selected Indian teachers who belong to the tradition of householder yogis. Special attention is directed to the rampant misconceptions about yoga in the contemporary urban Indian environment. The author also shares her own journey of healing as a student of yoga. The chapter also reflects upon the responsibilities of a yoga student, the versatile nature of a teacher, the importance of an appropriate yoga space, a supportive spiritual community and a pedagogy that considers a holistic view of health and responds to the specific needs and conditions of an individual.
Pilgrimage walking as green prescription self-therapy?
Authors: Jørgensen N. N. K. D. 
Published: November 2017

Abstract

It is argued that pilgrimage walking (if prescribed as an outdoor therapy alongside/instead of medicines) could reduce Norway's hospitalizations, medication use, health queues and spending, and also help people obtain relief by using their own personal health assets. To support this view, the chapter shows how present-day pilgrimages, like walking the Camino de Santiago de Compostela can be used as a self-therapeutic tool.
The social self on pilgrimage: intercession and mediation.
Authors: Muir S. 
Published: November 2017

Abstract

This chapter examines 'intercessory' pilgrimage, or instances when someone undertakes a pilgrimage on behalf of another person, in order to receive a benefit for that person. This sort of pilgrimage suggests an important issue: persons do not exist in isolation or act only for personal gain. The life of the individual is woven into the fabric of their family, friends and community. The chapter uses ancient Greece and Rome as a case study and provides examples of highly developed cases of social networks and social identity in pilgrimage to healing sites.
Let us be human: Wittgenstein and philosophical pilgrimage.
Authors: Sayre P. A. 
Published: November 2017

Abstract

This chapter focuses on visits to sites associated with the philosopher Ludwig Wittgenstein, including his grave in Cambridge, the Norwegian village of Skjolden and the isolated Austrian village of Trattenbach. It is argued that these journeys belong to a distinct genre of pilgrimage, 'philosophical pilgrimage', which emphasizes Wittgenstein's view of 'Let us be human'. It is suggested that contemporary philosophical pilgrimages of this sort are neither sacred nor secular, but mediate between the two.
The pilgrimage to the mausoleum of Sidi Shaykh.
Authors: Abbou T. 
Published: November 2017

Abstract

This chapter discusses various theories of Sufism and describes the pilgrimage to the Mausoleum of Sidi Shaykh, a yearly celebration that takes place in the Algerian West Saharan Atlas region. In Islam, such a pilgrimage is not looked upon favourably by some clerics. Hardliners believe contact between the people and Allah should be undertaken directly, without intermediaries like the Sufi saints. The chapter traces the origins of this pilgrimage, its evolution, the practices and rituals it involves, and recent challenges and international recognition via the UNESCO Convention for the Safeguarding of the Intangible Cultural Heritage.
'My heart wouldn't accept the advice': paths to self and community in Alevi poetry.
Authors: Carspecken L. , Özdoğan Z. 
Published: November 2017

Abstract

This chapter deals with the Alevi population, Turkey's largest religious minority. The chapter takes the reader on a journey through the works of three poets with the strongest influence on current Alevi culture (Shah Ismail, Pir Sultan Abdal and Kul Himmet) as a historical and cultural guide for individual and community pilgrimage, and to acknowledge the contribution Alevism makes to Turkey's eclectic heritage.
A call for curriculum reform to combat refugees crisis: the case of Lebanon
Authors: Awada Ghada , Diab Hassan , Faour Kawthar 
Published: November 2017

ABSTRACTThe study was set to elicit teachers’ perceptions of adopting a new curriculum integrating Human Rights Education (HRE) into most school subjects and developing textbooks which could address the mainstreaming of the Syrian children into the Lebanese schools especially after the influx of more than 1.2 million Syrian refugees who migrated to Lebanon due to the outbreak of civil war in Syria in 2011. The present study employed a descriptive qualitative methodology design. Thus, the policy context and current HRE literature were assessed and reported along with the responses to a survey developed by BEMIS, a national body established in 2001 to promote and develop capacity and support inclusion and integration of ethnic minorities in Scotland. The BEMIS survey was conducted as a mapping exercise eliciting data required to help address the study questions. The study findings yielded recommendations that underscored the necessity of developing new curriculum and textbooks integrating HRE focused on accepting diversity, building peace culture, democracy and citizenship as well as utilizing the whole‐school approach and the transformative model.