bluuebunny/crossref_metadata_2025_split huggingface dataset:
osce Mediation in an Eroding International Order
Authors: Remler Philip 
Published: September 2017

The feeling is widespread in the West that the post wwii normative international order has been under severe challenge since Russia’s seizure of Crimea, now exacerbated by statements from the American president casting doubt on the institutions that underpin that order. Is there a future role for osce mediation as this order erodes? Study of the Ukraine crisis in light of other protracted conflicts on the territory of the former Soviet Union shows that the same challenges have existed for a generation. Because the conflicts were small, however, the international community chose to accept a fiction of convenience to isolate them from an otherwise functioning international order: the narrative that the separatists sought independence, not (as in reality) a re-drawing of post-Soviet borders. This isolation is under pressure both from the new experience in Ukraine and from the extension of ever-greater Russian control over the separatists, amounting to crypto-annexation, despite a backlash from Moscow’s clients, including in Armenia. There is little likelihood of a resolution to the Ukraine crisis, including Russia’s annexation of Crimea, and prospects for mediation to resolve the conflicts remain dim. However, continued talks may resolve some humanitarian issues and provide a release valve to prevent pressures boiling over into renewed open warfare.
In 2015 the present author published an article outlining some effects of the Ukraine crisis on protracted conflicts in the osce area and on osce mediation in those conflicts.
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He has been asked to revisit his assessment of that time in light of subsequent events in world politics (in particular the advent of a new administration in the United States) and in the region. The new developments give little cause for optimism that settlement in any of the conflicts is closer. Rather, the question for the osce is whether the international community, in view of the challenges posed by the Ukraine crisis, should continue to engage in the fictions that have allowed it to manage the conflicts since their beginnings in the collapsing Soviet Union.
Impact of Frequent Interruption on Nurses’ Patient-Controlled Analgesia Programming Performance
Authors: Campoe Kristi R. , Giuliano Karen K. 
Published: September 2017

Objective: The purpose was to add to the body of knowledge regarding the impact of interruption on acute care nurses’ cognitive workload, total task completion times, nurse frustration, and medication administration error while programming a patient-controlled analgesia (PCA) pump. Background: Data support that the severity of medication administration error increases with the number of interruptions, which is especially critical during the administration of high-risk medications. Bar code technology, interruption-free zones, and medication safety vests have been shown to decrease administration-related errors. However, there are few published data regarding the impact of number of interruptions on nurses’ clinical performance during PCA programming. Method: Nine acute care nurses completed three PCA pump programming tasks in a simulation laboratory. Programming tasks were completed under three conditions where the number of interruptions varied between two, four, and six. Outcome measures included cognitive workload (six NASA Task Load Index [NASA-TLX] subscales), total task completion time (seconds), nurse frustration (NASA-TLX Subscale 6), and PCA medication administration error (incorrect final programming). Results: Increases in the number of interruptions were associated with significant increases in total task completion time ( p = .003). We also found increases in nurses’ cognitive workload, nurse frustration, and PCA pump programming errors, but these increases were not statistically significant. Applications: Complex technology use permeates the acute care nursing practice environment. These results add new knowledge on nurses’ clinical performance during PCA pump programming and high-risk medication administration.
Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease
Authors: Hyacinth Hyacinth I , Sugihara Courtney L , Spencer Thomas L , Archer David R , Shih Andy Y 
Published: September 2017

Stroke is a dramatic complication of sickle cell disease (SCD), which is associated with cerebral vasculopathies including moya moya, intravascular thrombi, cerebral hyperemia, and increased vessel tortuosity. The spontaneous occurrence of these pathologies in the sickle cell mouse model has not been described. Here, we studied Townes humanized sickle cell and age-matched control mice that were 13 months old. We used in vivo two-photon microscopy to assess blood flow dynamics, vascular topology, and evidence of cerebral vasculopathy. Results showed that compared to controls, sickle cell mice had significantly higher red blood cell (RBC) velocity (0.73 mm/s vs. 0.55 mm/s, p = 0.013), capillary vessel diameter (4.84 µM vs. 4.50 µM, p = 0.014), and RBC volume flux (0.015 nL/s vs. 0.010 nL/s, p = 0.021). Also, sickle cell mice had significantly more tortuous capillary vessels ( p < 0.0001) and significantly shorter capillary vessel branches ( p = 0.0065) compared to controls. Sickle cell mice also had significantly higher number of capillary occlusive events (3.4% vs. 1.9%, p < 0.0001) and RBC stalls (3.8% vs. 2.1%, p < 0.0001) in the cerebral capillary bed. In post-mortem immunohistochemical analyses, sickle cell mice had a 2.5-fold higher frequency of cortical microinfarcts compared to control mice. Our results suggest that aged Townes sickle cell mice spontaneously develop SCD-associated cerebral vasculopathy.
Prognostic Value of Brain Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-analysis
Authors: Sánchez Fernández Iván , Morales-Quezada J. Leon , Law Samuel , Kim Paggie 
Published: September 2017

Objective: To quantify the prognostic value of neonatal brain magnetic resonance imaging (MRI) in neonatal hypoxic-ischemic encephalopathy. Methods: Meta-analysis of studies with ≥35-week neonates with hypoxic-ischemic encephalopathy who underwent brain MRI within age 4 weeks and had neurodevelopmental follow-up for at least 12 months. Results: An abnormal neonatal brain MRI was more frequent among patients with unfavorable neurodevelopmental outcome: odds ratio = 18.2 (95% confidence interval: 9.4-34.9), P <.0001. The prognostic value of neonatal brain MRI in moderate hypoxic-ischemic encephalopathy had an odds ratio of 17.7 (95% confidence interval: 5.3-59.3) and in severe hypoxic-ischemic encephalopathy, the odds ratio was 125.0 (95% confidence interval: 2.0-7917.1). Therapeutic hypothermia did not change the prognostic value of neonatal brain MRI (odds ratio for hypothermia, 14.0 [95% confidence interval: 3.1-63.6], vs no hypothermia, 18.1 [95% confidence interval: 10.0-33.1], P = .7525). Conclusion: Neonatal brain MRI provides prognostic information on outcome beyond early infancy in hypoxic-ischemic encephalopathy and therapeutic hypothermia does not change its prognostic value.
Comparative Patient Satisfaction and Feasibility of a Pilot Parkinson’s Disease Enrichment Program
Authors: Choudhury Tabina K. , Harris Celeste , Crist Kathleen , Satterwhite Terry K. , York Michele K. 
Published: September 2017

Background: Available treatment options for Parkinson's disease (PD) are primarily aimed at pharmacological and/or neurosurgical management of motor symptoms. However, many patients also experience chronic non-motor symptoms (NMS), including significant cognitive and mood changes. Currently, there is a gap in the neuropsychological literature regarding the efficacy of nonpharmacological treatment options for cognitive and mood changes in PD. Objective: We sought to evaluate the efficacy and patient satisfaction of a pilot nonpharmacological intervention for alleviating NMS in patients with PD. Methods: Twenty-three independently functioning nondemented patients with PD participated in a 5-week Parkinson’s Disease Enrichment Program. Each 4-hour weekly session included content which addressed the following components: education, exercise, recreation, and socialization/support. Participants received a pre-assessment, including cognitive tests and questionnaires for depression and quality of life. After the completion of the program, participants completed post-assessment batteries to measure changes in neurocognitive and psychiatric status, as well as patient satisfaction regarding the program. Results: Neuropsychological data from pre- and post-assessments revealed significant improvements in measures of executive functioning, memory, and depressive symptoms. No significant changes were observed on the remaining mood or cognitive measures. One hundred percent of participants reported enjoyment from socialization with other participants with PD and satisfaction with the program overall. Conclusions: Positive preliminary results suggest that further expansion of this nonpharmacological pilot program for treatment of NMS may be beneficial for patients with PD. Future studies will investigate a larger cohort of participants with PD and cross-validate findings in demographically diverse samples.
A Clustered Randomized Trial of an Educational Intervention During Transplant Evaluation to Increase Knowledge of Living Donor Kidney Transplant
Authors: Weng Francis L. , Peipert John D. , Holland Bart K. , Brown Diane R. , Waterman Amy D. 
Published: September 2017

Introduction: Maximizing education about living donor kidney transplant (LDKT) during the in-person evaluation at the transplant center may increase the numbers of kidney patients pursuing LDKT. Research Questions and Design: To test the effectiveness of a 1-time LDKT educational intervention, we performed a cluster-randomized trial among 499 patients who presented for evaluation of kidney transplant. We compared usual care education (n = 250) versus intensive LDKT education (n = 249), which was implemented only on the evaluation day and consisted of viewing a 25-minute video of information and stories about LDKT and discussion of LDKT possibilities with an educator. Our primary outcome was knowledge of LDKT, 1 week after the transplant evaluation. Results: One week after evaluation, patients who received intensive education had higher knowledge than patients who received usual care (12.7 vs. 11.7; P = .0008), but there were no differences in postevaluation readiness for LDKT. Among patients who had not previously identified a potential living donor, receiving intensive education was associated with increased willingness to take steps toward LDKT. Discussion: In conclusion, expansion of LDKT education within the evaluation day may be helpful, but interventions that are implemented at multiple times and for greater duration may be necessary to ensure larger and long-term behavioral changes in pursuit of LDKT.
A fair electronic payment system for digital content using elliptic curve cryptography
Authors: Kang Baoyuan , Shao Dongyang , Wang Jiaqiang 
Published: September 2017

With rapid development of information and communication technologies purchasing digital content through the Internet has been greatly increased. Therefore, secure and fair electronic payment systems are important issue. To reduce system computational, communication and storage costs in many existing electronic schemes, Yang et al. recently proposed a novel electronic payment system based on authenticated encryption technology. But, Chaudhry et al. showed that Yang et al.'s electronic payment system is vulnerable to impersonation attack. Furthermore, Chaudhry et al. proposed improved electronic payment system. But, in this paper we point that Chaudhry et al.'s improved electronic payment system does not satisfy anonymity and fairness properties and the dispute resolution means in Chaudhry et al.'s electronic payment system are not effective. Furthermore, combining authenticated encryption and verifiably encrypted signatures technologies, we propose an improvement on Chaudhry et al.'s electronic payment system. Compared with Chaudhry et al.'s electronic payment system, the major changes of the proposed electronic payment system are in exchange phase. In this phase the private key and public key of the user are not needed, and the user generates verifiably encrypted signatures on his payment voucher. These changes guarantee the user anonymity, eliminate the advantages of the merchant, ensure the fairness of the payment system and the effectiveness of the dispute resolution phase. We also give the comparisons of proposed electronic payment system with some existing electronic payment systems.
New Partner Recruitment to Rural Versus Urban Ob-Gyn Practices
Authors: Fialkow Michael F. , Snead Carrie M. , Schulkin Jay 
Published: September 2017

Purpose: The purpose of this pilot study was to investigate the recruitment efforts of practicing obstetrics and gynecology (ob-gyns) from rural and urban practices. Method: The authors surveyed practicing ob-gyns from 5 states in the Pacific Northwest in 2016 about their background, practice setting, practice profile, partner recruitment, and retention. Results: Seventy-three patients completed the study (53.2% response rate). Thirty-seven percent of respondents work in an urban practice and 43% have a rural practice, with the remainder in a suburban setting. A majority of the respondents attempted to recruit a new partner in the past 5 years. Respondents were most interested in experience and diversity in new recruits. Urban respondents, however, were more interested in hiring those with specialized skills (χ2 = 7.842, P = .02) than rural providers who were more interested in partners familiar with their community (χ2= 7.153, P = .03). Reasons most often cited to leave their practice were reimbursement, limited social/marital options, and workload, other than rural providers who more often also cited lack of access to specialty care (χ2= 13.256, P = .001). Rural providers were more likely to cite marital and family status as an advantage to recruitment, whereas urban and suburban providers were more often neutral. Conclusions: Reduced access to care has led to significant health disparities for women living in rural communities. Understanding which providers are most likely to be successful in these settings might help preserve access as our health-care systems evolves.
What is culturally informed psychiatry? Cultural understanding and withdrawal in the clinical encounter
Authors: Leseth Anne Birgitte 
Published: September 2017

SummaryWhat is culturally informed psychiatry? What does it mean, and why is it important? These questions are discussed with a focus on the cultural aspects of the clinical encounter. The DSM-5 Outline for Cultural Formulation was developed as a method of assessing the cultural factors affecting the clinical encounter. It calls for the assessment of the cultural features of the relationship between the patient and the clinician; however, there is a lack of debate about what this means in practice. Clinicians run the risk of withdrawal rather than cultural understanding when facing patients with different cultural backgrounds. Using ethnographic material from anthropological fieldwork, I suggest that the encounter with cultural differences could be a useful point of departure for the clinician to develop cultural understanding. It is argued that recognising the experiences of differences is crucial in strengthening transcultural communication and preventing misdiagnosis in the clinician–patient encounter.
Trauma exposure and refugee status as predictors of mental health outcomes in treatment-seeking refugees
Authors: Knipscheer Jeroen W. , Sleijpen Marieke , Mooren Trudy , ter Heide F. Jackie June , van der Aa Niels 
Published: September 2017

Aims and methodThis study aimed to identify predictors of symptom severity for post-traumatic stress disorder (PTSD) and depression in asylum seekers and refugees referred to a specialised mental health centre. Trauma exposure (number and domain of event), refugee status and severity of PTSD and depression were assessed in 688 refugees.ResultsSymptom severity of PTSD and depression was significantly associated with lack of refugee status and accumulation of traumatic events. Four domains of traumatic events (human rights abuse, lack of necessities, traumatic loss, and separation from others) were not uniquely associated with symptom severity. All factors taken together explained 11% of variance in PTSD and depression.Clinical implicationsTo account for multiple predictors of symptom severity including multiple traumatic events, treatment for traumatised refugees may need to be multimodal and enable the processing of multiple traumatic memories within a reasonable time-frame.
Juvenile delinquency, welfare, justice and therapeutic interventions: a global perspective
Authors: Young Susan , Greer Ben , Church Richard 
Published: September 2017

SummaryThis review considers juvenile delinquency and justice from an international perspective. Youth crime is a growing concern. Many young offenders are also victims with complex needs, leading to a public health approach that requires a balance of welfare and justice models. However, around the world there are variable and inadequate legal frameworks and a lack of a specialist workforce. The UK and other high-income countries worldwide have established forensic child and adolescent psychiatry, a multifaceted discipline incorporating legal, psychiatric and developmental fields. Its adoption of an evidence-based therapeutic intervention philosophy has been associated with greater reductions in recidivism compared with punitive approaches prevalent in some countries worldwide, and it is therefore a superior approach to dealing with the problem of juvenile delinquency.
The access and waiting-time standard for first-episode psychosis: an opportunity for identification and treatment of psychosis risk states?
Authors: Whale Richard , Thompson Andrew , Fraser Rick 
Published: September 2017

SummaryExpansion of early intervention services to identify and clinically manage at-risk mental state for psychosis has been recently commissioned by NHS England. Although this is a welcome development for preventive psychiatry, further clarity is required on thresholds for definition of such risk states and their ability to predict subsequent outcomes. Intervention studies for these risk states have demonstrated that a variety of interventions, including those with fewer adverse effects than antipsychotic medication, may potentially be effective but they should be interpreted with caution.
Effect of Inpatient Palliative Care During Hematopoietic Stem-Cell Transplant on Psychological Distress 6 Months After Transplant: Results of a Randomized Clinical Trial
Authors: El-Jawahri Areej , Traeger Lara , Greer Joseph A. , VanDusen Harry , Fishman Sarah R. , LeBlanc Thomas W. , Pirl William F. , Jackson Vicki A. , Telles Jason , Rhodes Alison , Li Zhigang , Spitzer Thomas R. , McAfee Steven , Chen Yi-Bin A. , Temel Jennifer S. 
Published: September 2017

Purpose Inpatient palliative care integrated with transplant care improves patients’ quality of life (QOL) and symptom burden during hematopoietic stem-cell transplant (HCT). We assessed patients’ mood, post-traumatic stress disorder (PTSD) symptoms, and QOL 6 months post-transplant. Methods We randomly assigned 160 patients with hematologic malignancies who underwent autologous or allogeneic HCT to inpatient palliative care integrated with transplant care (n = 81) or transplant care alone (n = 79). At baseline and 6 months post-transplant, we assessed mood, PTSD symptoms, and QOL with the Hospital Anxiety and Depression Scale and Patient Health Questionnaire, PTSD checklist, and Functional Assessment of Cancer Therapy-Bone Marrow Transplant. To assess symptom burden during HCT, we used the Edmonton Symptom Assessment Scale. We used analysis of covariance while controlling for baseline values to examine intervention effects and conducted causal mediation analyses to examine whether symptom burden or mood during HCT mediated the effect of the intervention on 6-month outcomes. Results We enrolled 160 (86%) of 186 potentially eligible patients between August 2014 and January 2016. At 6 months post-transplant, intervention participants reported lower depression symptoms on the Hospital Anxiety and Depression Scale and Patient Health Questionnaire (adjusted mean difference, −1.21 [95% CI, −2.26 to −0.16; P = .024] and −1.63 [95% CI, −3.08 to −0.19; P = .027], respectively) and lower PTSD symptoms (adjusted mean difference, −4.02; 95% CI, −7.18 to −0.86; P = .013), but no difference in QOL or anxiety. Symptom burden and anxiety during HCT hospitalization partially mediated the effect of the intervention on depression and PTSD at 6 months post-transplant. Conclusion Inpatient palliative care integrated with transplant care leads to improvements in depression and PTSD symptoms at 6 months post-transplant. Reduction in symptom burden and anxiety during HCT partially accounts for the effect of the intervention on these outcomes.
Perspectives on Polycystic Ovary Syndrome: Is Polycystic Ovary Syndrome Research Underfunded?
Authors: Brakta Soumia , Lizneva Daria , Mykhalchenko Kateryna , Imam Adonis , Walker Walidah , Diamond Michael P , Azziz Ricardo 
Published: September 2017

Abstract

Context
Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic abnormality with a worldwide prevalence of 4% to 21%, depending on diagnostic criteria. The National Institutes of Health (NIH) is the largest single funding agency in the world; it invests nearly $30.0 billion annually in biomedical research.

Evidence Acquisition
Using the NIH Research Portfolio Online Reporting tool, we searched for all grants awarded by the NIH for PCOS and three other disorders with similar degrees of morbidity and similar or lower mortality and prevalence [rheumatoid arthritis (RA), tuberculosis (TB), and systemic lupus erythematosus (SLE)].

Evidence Synthesis
We compared funding by the NIH for PCOS, RA, TB, and SLE research for the years 2006 to 2015, inclusive.

Conclusion
PCOS, compared with RA, TB, and SLE, was relatively less funded (total mean 10-year funding was $215.12 million vs $454.39 million, $773.77 million, and $609.52 million, respectively). Funding for PCOS was largely provided by one NIH Institute/Center (ICs) vs at least two ICs for SLE and RA; more individual Research Project Grants were awarded for RA, SLE, and TB than for PCOS, whereas PCOS funding was more likely to be through General Clinical Research Centers Program or Specialized Centers Program awards. Our data suggest that PCOS research may be underfunded considering its prevalence, economic burden, metabolic morbidity, and negative impact on quality of life. Greater education of NIH leaders, including those at the National Heart, Lung, and Blood Institute and National Institutes of Diabetes and Digestive and Kidney Diseases; other federal and state agency leads; elected leaders; and the general public by professional societies, the scientific community, and patient advocates regarding this disorder is needed.
Mechanoregulation of clathrin-mediated endocytosis
Authors: Ferguson Joshua P. , Huber Scott D. , Willy Nathan M. , Aygün Esra , Goker Sevde , Atabey Tugba , Kural Comert 
Published: September 2017

ABSTRACT
We characterized the tension response of clathrin-mediated endocytosis by using various cell manipulation methodologies. Elevated tension in a cell hinders clathrin-mediated endocytosis through inhibition of de novo coat initiation, elongation of clathrin coat lifetimes and reduction of high-magnitude growth rates. Actin machinery supplies an inward pulling force necessary for internalization of clathrin coats under high tension. These findings suggest that the physical cues cells receive from their microenvironment are major determinants of clathrin-mediated endocytic activity.