bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio‐functional properties of sardine protein hydrolysates obtained by brewer's spent yeast and commercial proteases
Authors: Vieira Elsa F , Pinho Olívia , Ferreira Isabel MPLVO 
Published: May 2017

AbstractBACKGROUNDThe canned‐sardine industry generates large amounts of protein‐rich waste, which demands useful exploitation. This paper describes the potential use of muscle and viscera proteins from canned sardine by‐products as substrate to obtain hydrolysates with biological and functional properties. Three enzymatic approaches, brewer's spent yeast (Bsy) proteases, Alcalase® and Neutrase® were applied to perform protein hydrolysis at the same proteolytic activity (1 U mL−1), using an enzyme/substrate ratio of 20% (v/v), at 50°C and for 7 h. Hydrolysis degree (DH), antioxidant and angiotensin I‐converting enzyme inhibitory (ACE‐I) activities, functional properties (i.e. solubility, emulsifying and foaming properties, water and oil binding capacity) and colour were investigated.RESULTSAll hydrolysates presented a high protein content [52.7–83.2% dry weight (DW)] and low fat content (0.9–3.9% DW). Alcalase® treatment of muscle and viscera proteins resulted in higher DH (7.5% and 8.6%, respectively) and higher biological activities (P < 0.05). All hydrolysates had excellent solubility and presented functional properties. Among viscera hydrolysates, treatment with Bsy proteases promoted higher emulsion (80.1 m2 g−1), foaming (79.2%) and oil binding capacity (5.8 g g−1) of viscera sardine proteins.CONCLUSIONImproved biological and functional properties were observed for sardine protein hydrolysates produced using the three enzymatic treatments tested. © 2017 Society of Chemical Industry
Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts
Authors: Pilotto Andrea , Heinzel Sebastian , Suenkel Ulrike , Lerche Stefanie , Brockmann Kathrin , Roeben Benjamin , Schaeffer Eva , Wurster Isabel , Yilmaz Rezzak , Liepelt‐Scarfone Inga , von Thaler Anna‐Katharina , Metzger Florian G. , Eschweiler Gerhard W. , Postuma Ron B. , Maetzler Walter , Berg Daniela 
Published: May 2017

ABSTRACTBackground: The research criteria for prodromal PD of the MDS propose a new approach for the assessment of the individual probability of prodromal PD. These criteria require a testing of their reliability in different prospective cohorts.Objectives: The objective was to evaluate the MDS prodromal PD criteria in 2 independent prospective studies.Methods: Prodromal PD probabilities of the Tübingen Evaluation of Risk Factors for Early Detection of Neurodegeneration cohort (TREND study, n = 650, recruited by the presence of probable rapid eye movement sleep behavior disorder, depression, and/or hyposmia or none of these at baseline and 2‐, 4‐, and 6‐year follow‐up) and the population‐based Prospective Evaluation of Risk Factors for Idiopathic Parkinson's Syndrome cohort (PRIPS Tübingen subsample; n = 715, baseline and 3‐ and 5‐year follow‐up) were calculated. Baseline posttest probabilities, time to PD diagnosis, marker constellations, and longitudinal changes of prodromal PD probabilities were analyzed.Results: Incident PD cases (TREND, n = 10; PRIPS = 7) showed significantly higher likelihood ratios of risk and prodromal markers at baseline when compared with nonconverters. Only 2 of 17 incident PD cases met the criteria for probable prodromal PD (ie, posttest probability > 80%) and 5 had possible prodromal PD (ie, > 50%) 1.4 to 3.8 years before diagnosis. The criteria showed high specificity and negative predictive values (>98%), but low sensitivity (TREND, 30%; PRIPS, 14%) and positive predictive values (TREND, 19%, PRIPS, 50%). The individual risk for prodromal PD in incident PD cases showed an inverse correlation with the time to conversion (Spearman rho = .80, P = .006) and unlike in nonconverters, increased during follow‐up.Conclusion: The MDS prodromal criteria provide a practical framework for the calculation of prodromal PD risk. Although specificity of the criteria is high, most patients will not meet the criteria before diagnosis unless testing is thoroughly performed with numerous and highly specific markers objectively assessed. © 2017 International Parkinson and Movement Disorder Society
Application of Combination High‐Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product‐Based Combination Drugs
Authors: Isgut Monica , Rao Mukkavilli , Yang Chunhua , Subrahmanyam Vangala , Rida Padmashree C. G. , Aneja Ritu 
Published: May 2017

AbstractModern drug discovery efforts have had mediocre success rates with increasing developmental costs, and this has encouraged pharmaceutical scientists to seek innovative approaches. Recently with the rise of the fields of systems biology and metabolomics, network pharmacology (NP) has begun to emerge as a new paradigm in drug discovery, with a focus on multiple targets and drug combinations for treating disease. Studies on the benefits of drug combinations lay the groundwork for a renewed focus on natural products in drug discovery. Natural products consist of a multitude of constituents that can act on a variety of targets in the body to induce pharmacodynamic responses that may together culminate in an additive or synergistic therapeutic effect. Although natural products cannot be patented, they can be used as starting points in the discovery of potent combination therapeutics. The optimal mix of bioactive ingredients in natural products can be determined via phenotypic screening. The targets and molecular mechanisms of action of these active ingredients can then be determined using chemical proteomics, and by implementing a reverse pharmacokinetics approach. This review article provides evidence supporting the potential benefits of natural product‐based combination drugs, and summarizes drug discovery methods that can be applied to this class of drugs.
Soft tissue reconstruction and salvage of infected fixation hardware in lower extremity trauma
Authors: Leland Hyuma A. , Rounds Alexis D. , Burtt Karen E. , Gould Daniel J. , Marecek Geoffrey S. , Alluri Ram K. , Patel Ketan M. , Carey Joseph N. 
Published: May 2017

BackgroundTibial fracture management may be complicated by infection of internal fixation hardware (iIFH) resulting in increased morbidity and amputation rate. When iIFH removal is not possible, salvage of the lower extremity is attempted through debridement, antibiotics, and vascularized soft tissue coverage. This study investigates lower extremity salvage with retention of iIFH.MethodsDemographics, outcomes, and bacterial speciation in patients with tibial fractures at a level 1 trauma center from 2007 to 2014 were reviewed. The primary outcome was infection suppression, while secondary outcomes included limb salvage, amputation, and osseous union.ResultsTwenty‐five patients underwent soft tissue reconstruction for salvage of iIFH. Average age was 41, 19 (76%) were male, average BMI 30.1 kg/m2, 10 (40%) patients smoked. Tibial fractures were closed in 8 (32%), Gustilo‐Anderson grade I in 1 (4%), II in 8 (32%), IIIb in 5 (20%), and IIIc in 1 (4%). Staphylococcus was most commonly cultured with 11 (44%) demonstrating methicillin‐resistance. Soft tissue reconstruction was performed by local flap in 15 (60%) and free flap in 10 (40%). At an average of 16.1 months, 19 (76%) hardware salvage patients demonstrated clinical suppression of infection, 11 of 19 (57.9%) patients had bony union, and 24 (96%) maintained a salvaged limb. One patient was amputated for recurrent infection.ConclusionsFollowing complex, infected tibial fractures, salvage of the lower extremity may be attempted even when iIFH cannot be removed. Thorough debridement, antibiotics, and vascularized soft tissue may suppress infection long enough to facilitate osseous union and subsequent removal of iIFH.
The Greek Registry of Shwachman Diamond‐Syndrome: Molecular and clinical data
Authors: Delaporta Polyxeni , Sofocleous Christalena , Economou Marina , Makis Alexandros , Kostaridou Stavroula , Kattamis Antonis 
Published: May 2017

AbstractThis study presents the clinical phenotype and molecular analysis findings from 11 patients recorded in the Greek Shwachman–Diamond syndrome (SDS) Registry. The most severely affected patient in our registry was diagnosed at birth and is the first patient reported to require bone marrow transplantation so early in life. Severe psoriasis, a feature not previously reported in SDS, was observed in one patient. Mutations in the Shwachman–Bodian–Diamond syndrome gene (SBDS) were found in all patients. Cytogenetic analyses revealed clonal abnormalities, one novel, in two patients.
Paratesticular desmoplastic small round cell tumors: A case report and review of the literature
Authors: Sedig Laura , Geiger James , Mody Rajen , Jasty‐Rao Rama 
Published: May 2017

AbstractDesmoplastic small round cell tumor (DSCRT) is a rare malignancy most often seen in the abdomen or pelvis of young men. Unfortunately, this disease is usually metastatic at diagnosis and has dismal outcomes. We describe a case of isolated paratesticular DSCRT in a 14‐year‐old male successfully treated with surgical resection, chemotherapy, and adjuvant radiation, and we present a review of the relevant literature. It appears that isolated, paratesticular DSCRTs have a markedly better outcome than the classic abdominal or pelvic location. We hypothesize that this is due to earlier detection and the relative ease of surgical resection.
H3.1 K36M mutation in a congenital‐onset soft tissue neoplasm
Authors: Kernohan Kristin D. , Grynspan David , Ramphal Raveena , Bareke Eric , Wang You Chang , Nizalik Elizabeth ,   Care4Rare Canada Consortium, Ragoussis Jiannis , Jabado Nada , Boycott Kym M. , Majewski Jacek , Sawyer Sarah L. 
Published: May 2017

AbstractWe describe a patient who presented with a congenital soft tissue lesion initially diagnosed as infantile fibromatosis at 15 days of age. Unusually, the mass demonstrated malignant progression leading to death at 20 months of age. Biological progression to malignancy is not known to occur in fibromatosis, and fibrosarcoma is not known to progress from a benign lesion. Whole‐exome sequencing of the tumor identified a driver mutation in histone H3.1 at lysine (K)36. Our findings support the link between oncohistones and infantile soft tissue tumors and provide additional evidence for the oncogenic effects of p.K36M in H3 variants.
First use of antidepressant medication in male partners of women with breast cancer in Denmark from 1998 to 2011
Authors: Cromhout Pernille F. , Latocha Kristine M. , Olsen Maja H. , Suppli Nis P. , Christensen Jane , Johansen Christoffer , Dalton Susanne O. 
Published: May 2017

AbstractObjectiveA diagnosis of breast cancer disrupts the life of the patient, but also the partner may experience adverse psychological effects. We examined partners' risk for first use of antidepressant medication, as a proxy for pharmacologically treated depression.MethodsBy linkage of national registers, we identified 1 420 592 depression‐free men living with a cancer‐free female partner in 1998 to 2011. During follow‐up, breast cancer was diagnosed in female partners of 26 256 men. In Poisson regression models, we estimated the rate ratios for first use of antidepressant medication compared to partners of breast cancer‐free women. Cox regression analyses examined associations between exposed partners' sociodemographic characteristics, somatic comorbidity, death of female partner, and first use of antidepressant medication.ResultsMale partners of women with breast cancer had an increased rate ratio of 1.08 (95% CI, 1.03‐1.13) for first use of antidepressant medication compared to the background population, corresponding to excess absolute risk of 12 cases per 10 000 person‐years. This increased risk persisted throughout 14 years of follow‐up. Higher age, shorter education, somatic comorbidity, and death of female partner were associated with increased risk among men whose partner had breast cancer.ConclusionThe modest, but long term, increased risk for first use of antidepressant medication calls for attention by health care professionals to symptoms of depression among partners of breast cancer patients.
First‐principles calculations of thermodynamic properties and planar fault energies in Co3X and Ni3X L12 compounds
Authors: Breidi A. , Allen J. , Mottura A. 
Published: May 2017

AbstractWe do Density Functional Theory based total‐energy calculations of the phase in X and X compounds, X being a transition metal element. The lattice parameters, magnetic moments and formation enthalpies are determined and compared with the available experimental data. The (111) superlattice intrinsic stacking fault energy (SISF), a crucial factor affecting materials strength and their mechanical behavior, is calculated using the axial interaction model. We have applied the quasiharmonic Debye model in conjunction with first‐principles in order to establish the temperature dependence of the lattice parameters and the (111) SISF energies. We investigate our prediction of a low formation enthalpy in the system Ni −25 at.%Zn by doing auxiliary simulations for the fcc random alloy at the composition 25 at.%Zn. Our simulations indicate that the elements Ti, Zr, Hf, Nb, and Ta can help stabilizing the promising and extremely important alloy.
Design of small hand‐launched solar‐powered UAVs: From concept study to a multi‐day world endurance record flight
Authors: Oettershagen Philipp , Melzer Amir , Mantel Thomas , Rudin Konrad , Stastny Thomas , Wawrzacz Bartosz , Hinzmann Timo , Leutenegger Stefan , Alexis Kostas , Siegwart Roland 
Published: May 2017

AbstractWe present the development process behind AtlantikSolar, a small 6.9 kg hand‐launchable low‐altitude solar‐powered unmanned aerial vehicle (UAV) that recently completed an 81‐hour continuous flight and thereby established a new flight endurance world record for all aircraft below 50 kg mass. The goal of our work is to increase the usability of such solar‐powered robotic aircraft by maximizing their perpetual flight robustness to meteorological deteriorations such as clouds or winds. We present energetic system models and a design methodology, implement them in our publicly available conceptual design framework for perpetual flight‐capable solar‐powered UAVs, and finally apply the framework to the AtlantikSolar UAV. We present the detailed AtlantikSolar characteristics as a practical design example. Airframe, avionics, hardware, state estimation, and control method development for autonomous flight operations are described. Flight data are used to validate the conceptual design framework. Flight results from the continuous 81‐hour and 2,338 km covered ground distance flight show that AtlantikSolar achieves 39% minimum state‐of‐charge, 6.8 h excess time and 6.2 h charge margin. These performance metrics are a significant improvement over previous solar‐powered UAVs. A performance outlook shows that AtlantikSolar allows perpetual flight in a 6‐month window around June 21 at mid‐European latitudes, and that multi‐day flights with small optical‐ or infrared‐camera payloads are possible for the first time. The demonstrated performance represents the current state‐of‐the‐art in solar‐powered low‐altitude perpetual flight performance. We conclude with lessons learned from the three‐year AtlantikSolar UAV development process and with a sensitivity analysis that identifies the most promising technological areas for future solar‐powered UAV performance improvements.
Adverse Childhood Experiences (ACEs), Stress and Mental Health in College Students
Authors: Karatekin Canan 
Published: May 2017

AbstractThe goal of this short‐term longitudinal study was to examine whether adverse childhood experiences (ACEs) could be used to identify college students at risk for mental health problems and whether current level of stress mediates the relationship between ACEs and mental health. Data on ACEs and mental health (depression, anxiety and suicidality) were collected at the beginning of the semester, and data on current stressors and mental health were collected toward the end of the semester (n = 239). Findings indicated that ACEs predicted worsening of mental health over the course of a semester and suggested current number of stressors as a mediator of the relationship between ACEs and mental health. Results suggest that screening for ACEs might be useful to identify students at high risk for deterioration in mental health. Results further suggest that stress‐related interventions would be beneficial for students with high levels of ACEs and point to the need for more research and strategies to increase help‐seeking in college students.
Building design‐time and run‐time knowledge for QoS‐based component assembly
Authors: Caporuscio Mauro , Mirandola Raffaela , Trubiani Catia 
Published: May 2017

SummaryModern software systems are required to dynamically adapt to changing workloads, scenarios, and objectives and to achieve a certain Quality of Service (QoS). Guaranteeing QoS requirements is not trivial, as run‐time uncertainty might invalidate the design‐time rationale, where software components have been selected by means of off‐line analysis. In this work, we propose a QoS‐based feedback approach that makes a combined use of design‐time predictions and run‐time measurements to manage QoS data over time and support software architects while selecting software components that best fit QoS requirements. We illustrate the feasibility and efficacy of the approach on a case study, where the quantitative evaluation shows how the analysis effectively identifies the sources of QoS violations and indicates possible solutions to achieve QoS requirements.
Catalytic Asymmetric Inverse‐Electron‐Demand Hetero‐Diels−Alder Reactions
Authors: Xie Mingsheng , Lin Lili , Feng Xiaoming 
Published: May 2017

AbstractIn this review, the recent developments in catalytic asymmetric inverse‐electron‐demand hetero‐Diels−Alder reaction, which is recognized as one of the most powerful routes to construct highly functionalized and enantioenriched six‐membered heterocycles, are described. The article is organized on the basis of different kinds of electron‐deficient heterodienes, including α,β‐unsaturated ketones/aldehydes, o‐benzoquinones, α,β‐unsaturated imines, N‐aryl imines, o‐benzoqinone imides, and other aza‐olefins.
Fetal cardiac remodeling in twin pregnancy conceived by assisted reproductive technology
Authors: Valenzuela‐Alcaraz B. , Cruz‐Lemini M. , Rodríguez‐López M. , Goncé A. , García‐Otero L. , Ayuso H. , Sitges M. , Bijnens B. , Balasch J. , Gratacós E. , Crispi F. 
Published: May 2017

ABSTRACTObjectiveRecent data suggest that singleton fetuses conceived by assisted reproductive technology (ART) present cardiovascular remodeling that may persist postnatally. Twin pregnancies are more frequent in the ART population and are associated with increased adverse perinatal outcomes, such as hypertensive disorders, gestational diabetes and preterm birth. However, it is unknown whether cardiac remodeling is also present in twin pregnancies conceived by ART. Our aim was to assess the presence of fetal cardiac remodeling and dysfunction in twin pregnancies conceived by ART as compared with those conceived spontaneously (SC).MethodsThis was a prospective cohort study including 50 dichorionic twin fetuses conceived by ART and 50 SC twin fetuses. The study protocol included collection of baseline/perinatal data and a fetal ultrasound examination at 28–30 weeks' gestation, including assessment of estimated fetal weight, fetoplacental Doppler and fetal echocardiography. Measurements of atrial area, atrial/heart ratio, ventricular sphericity index, free wall thickness, mitral and tricuspid annular plane systolic excursions, and systolic and early diastolic peak velocities were assessed. Multilevel analyses were used to compare perinatal and ultrasonographic parameters. Comparisons of echocardiographic variables were adjusted for parental age, paternal body mass index and incidence of pre‐eclampsia.ResultsCompared with SC twins, ART twin fetuses showed significant cardiac changes, predominantly affecting the right heart, such as dilated atria (right atrial/heart area: 15.7 ± 3.1 vs 18.4 ± 3.2, P < 0.001), more globular ventricles (right ventricular sphericity index: 1.57 ± 0.25 vs 1.41 ± 0.23, P = 0.001) and thicker myocardial walls (septal wall thickness: 2.57 ± 0.45 mm vs 2.84 ± 0.41 mm, P = 0.034) together with reduced longitudinal motion (tricuspid annular plane systolic excursion: 6.36 ± 0.89 mm vs 5.18 ± 0.93 mm, P < 0.001).ConclusionsART twin fetuses present signs of cardiac remodeling and dysfunction. These changes are similar to those observed in ART singletons and reinforce the concept of fetal cardiac programing in ART. These results open opportunities for early detection and intervention in infants conceived by ART. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
A panorama of dispersion curves for the weighted isotropic relaxed micromorphic model
Authors: d'Agostino Marco Valerio , Barbagallo Gabriele , Ghiba Ionel‐Dumitrel , Madeo Angela , Neff Patrizio 
Published: May 2017

AbstractWe consider the weighted isotropic relaxed micromorphic model and provide an in depth investigation of the characteristic dispersion curves when the constitutive parameters of the model are varied. The weighted relaxed micromorphic model generalizes the classical relaxed micromorphic model previously introduced by the authors, since it features the Cartan‐Lie decomposition of the tensors and in their , and spherical part. It is shown that the split of the tensor in the micro‐inertia provides an independent control of the cut‐offs of the optic banches. This is crucial for the calibration of the relaxed micromorphic model on real band‐gap metamaterials.Even if the physical interest of the introduction of the split of the tensor is less evident than in the previous case, we discuss in detail which is its effect on the dispersion curves. Finally, we also provide a complete parametric study involving all the constitutive parameters of the introduced model, so giving rise to an exhaustive panorama of dispersion curves for the relaxed micromorphic model.
Associations of lower vitamin D concentrations with cognitive decline and long‐term risk of dementia and Alzheimer's disease in older adults
Authors: Feart Catherine , Helmer Catherine , Merle Bénédicte , Herrmann François R. , Annweiler Cédric , Dartigues Jean‐François , Delcourt Cécile , Samieri Cécilia 
Published: May 2017

AbstractIntroductionHypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent.MethodsThe study population consisted of 916 participants from the Three‐City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years.ResultsIn multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three‐fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37–5.97).DiscussionThis large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.