bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant appendiceal mucinous cystadenoma treated by laparoscopy: a case report and review of the literature
Authors: Nogueira Felipe Ramos , Arruda Francisco Wendel de Sousa , Bezerra Carla Camila Rocha , Neto Benjamin Ramos de Andrade , Lopes Manoel Italo Pimentel Santos , Sousa Edson de Macedo , Santos Alessandra Marques dos , Marques Adryano Gonçalves , Rodrigues Lusmar Veras 
Published: May 2017

AbstractAppendiceal mucinous cystadenoma is a rare entity, which causes appendicular mucocele. It is more frequent in women over 50 years old. In half of the cases it is asymptomatic. Tomography of the abdomen is the gold standard in its preoperative diagnosis. The treatment is surgical, with good prognosis, the complete resection evolves without appendicular rupture and extravasation. We report a case of a 64-year-old man with appendiceal mucinous cystadenoma. A laparoscopic right hemicolectomy was performed. This therapy that can be safely used to treat appendiceal mucocele, as long as it is cautious.
Criteria for short QT interval based on a new QT‐heart rate adjustment formula
Authors: Rabkin Simon W. 
Published: May 2017

AbstractBackgroundA short QT interval, within which an increased risk for atrial fibrillation and/or fatal cardiac arrhythmias occurs, has been difficult to define.MethodsThe lower percentiles of a new QTc formula were determined, using a precise mathematical fitting of the QT‐heart rate relationship from the ECGs of 13,600 individuals from the NHANES II and III surveys.ResultsThe QTc interval for persons in the lower fifth percentile, second (2.5th) percentile and first percentile, were calculated.ConclusionsBased on the new spline formula, a short QTc is defined at the first percentile, and is less than 380 ms in both men and women.
Dual‐passive snubber dual‐switch forward converter
Authors: Soltanzadeh K. , Dehghani M. , Riahi R. 
Published: May 2017

A dual‐passive snubber (DPS) for dual‐switch forward converter is presented. Snubber networks provide zero‐current turn‐on and zero‐voltage turn‐off conditions for dual switches. DPS achieves soft switching conditions for power diodes at secondary side of transformer. The detailed circuit operation of converter with proposed passive snubber, theoretical analysis and design example are presented. The measured result taken from a laboratory prototype rated at 160 W (32 V/5 A), input voltage of 150 V‐DC and switching frequency of 300 kHz. The peak efficiency is 93%.
Effect of oleic acid on the stability and rheology of nanoaluminium/JP‐10 bi‐phase system
Authors: Chen Bing Hong , Liu Jian Zhong , Yao Feng , Li He Ping , Zhou Jun Hu 
Published: May 2017

Aluminium (Al) nanoparticles absorbed by oleic acid (OA) were prepared to study the effect and mechanism of OA on the stability and rheology of a nanoAl/exo‐tetrahydrodicyclopentadiene (JP‐10) bi‐phase system. The absorption layer was characterised by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and energy dispersive X‐ray spectroscopy. The effect of OA on the stability and rheology of nanoAl/JP‐10 suspensions was measured. Results show that OA reduces the surface tension of JP‐10 and the contact angle between the two phases. The absorption of OA on the surface of the particles occurred through the reaction between the −COOH of OA the −OH of Al particles. The amount of absorption increased as the concentration of OA increased. Adding OA enhanced the stability of the nanoAl/JP‐10 bi‐phase systems by hindering particles aggregation. A suspension with 5.0% solid load demonstrated no clear layer separation 1 month after preparation with 1.0% OA. OA also reduced the viscosity of the systems. A 0.5% concentration of OA is best for a system with 20% solid load. The viscosity‐reducing effect of OA was determined by its comparative amount, and the ratio of OA/Al should be above 2.5%.
Real-Time Methylation-Specific Polymerase Chain Reaction for MGMT Promoter Methylation Clinical Testing in Glioblastoma
Authors: Ida Cristiane M , Butz Malinda L , Jenkins Robert B , Sarkaria Jann N , Kitange Gaspar J , Giannini Caterina , Kipp Benjamin R 
Published: May 2017

Abstract

Objectives
To develop and evaluate a real-time methylation-specific polymerase chain reaction (RT-MSP) MGMT assay, with a particular focus on small biopsies and indeterminate testing results.

Methods
We assessed formalin-fixed paraffin-embedded glioblastoma or gliosarcoma specimens (n = 641). A test-validation group (n = 51) with previously obtained reference laboratory (RL) results was used to determine performance characteristics of the RT-MSP assay. An indeterminate (equivocal) category was established for cases that could not be clearly classified as positive or negative.

Results
Overall agreement of RT-MSP and RL results was 91% (41/45 nonindeterminate cases). Discordant cases were tested by pyrosequencing, and results were most concordant with RT-MSP. Among cases with limited amounts of tissue (n = 7), six yielded valid results by RT-MSP (all negative); the single invalid result consisted of a stereotactic biopsy specimen obtained 14 years prior. A subset of indeterminate cases obtained during clinical testing (n = 18/575 [3%]) was also evaluated by pyrosequencing and showed a heterogeneous pattern of methylation across the eight interrogated CpG sites.

Conclusions
The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma.
Application of the cghRA framework to the genomic characterization of Diffuse Large B-Cell Lymphoma
Authors: Mareschal Sylvain , Ruminy Philippe , Alcantara Marion , Villenet Céline , Figeac Martin , Dubois Sydney , Bertrand Philippe , Bouzelfen Abdelilah , Viailly Pierre-Julien , Penther Dominique , Tilly Hervé , Bastard Christian , Jardin Fabrice 
Published: May 2017

Abstract

Motivation
Although sequencing-based technologies are becoming the new reference in genome analysis, comparative genomic hybridization arrays (aCGH) still constitute a simple and reliable approach for copy number analysis. The most powerful algorithms to analyze such data have been freely provided by the scientific community for many years, but combining them is a complex scripting task.

Results
The cghRA framework combines a user-friendly graphical interface and a powerful object-oriented command-line interface to handle a full aCGH analysis, as is illustrated in an original series of 107 Diffuse Large B-Cell Lymphomas. New algorithms for copy-number calling, polymorphism detection and minimal common region prioritization were also developed and validated. While their performances will only be demonstrated with aCGH, these algorithms could actually prove useful to any copy-number analysis, whatever the technique used.

Availability and implementation
R package and source for Linux, MS Windows and MacOS are freely available at http://bioinformatics.ovsa.fr/cghRA.

Supplementary information
Supplementary data are available at Bioinformatics online.
Corynebacterium kroppenstedtii Is an Emerging Cause of Mastitis Especially in Patients With Psychiatric Illness on Antipsychotic Medication
Authors: Wong Sally C. Y. , Poon Rosana W. S. , Chen Jonathan H. K. , Tse Herman , Lo Janice Y. C. , Ng Tak-Keung , Au Jonathan C. K. , Tse Cindy W. S. , Cheung Ingrid Y. Y. , Yuk Man-Ting , Luk Wei-Kwang , Yuen Kwok-Yung 
Published: May 2017

Abstract
This retrospective study of patients with Corynebacterium kroppenstedtii infections revealed a predominance of mastitis and a potential association with psychiatric illnesses. At least one third of our patients with C kroppenstedtii mastitis had psychiatric illness, and &gt;92% received antipsychotic medications. Drug-induced hyperprolactinemia may be an important modifiable risk factor in these patients.
Early Intensive Leg Training to Enhance Walking in Children With Perinatal Stroke: Protocol for a Randomized Controlled Trial
Authors: Hurd Caitlin , Livingstone Donna , Brunton Kelly , Teves Michelle , Zewdie Ephrem , Smith Allison , Ciechanski Patrick , Gorassini Monica A. , Kirton Adam , Watt Man-Joe , Andersen John , Yager Jerome , Yang Jaynie F. 
Published: May 2017

Abstract
Background. Development of motor pathways is modulated by activity in these pathways, when they are maturing (ie, critical period). Perinatal stroke injures motor pathways, including the corticospinal tracts, reducing their activity and impairing motor function. Current intervention for the lower limb emphasizes passive approaches (stretching, braces, botulinum toxin injections). The study hypothesis was that intensive, early, child–initiated activity during the critical period will enhance connectivity of motor pathways to the legs and improve motor function.
Objective. The study objective was to determine whether early intervention with intensive activity is better than standard care, intervention delivered during the proposed critical period is better than after, and the outcomes are different when the intervention is delivered by a physical therapist in an institution vs. a parent at home.
Design. A prospective, delay-group, single-blind, randomized controlled trial (RCT) and a parallel, cohort study of children living beyond commuting distance and receiving an intervention delivered by their parent.
Setting. The RCT intervention was provided in university laboratories, and parent training was provided in the childs home.
Participants. Children 8 months to 3 years old with MRI-confirmed perinatal ischemic stroke and early signs of hemiparesis.
Intervention. Intensive, play-based leg activity with weights for the affected leg and foot, 1 hour/day, 4 days/week for 12 weeks.
Measurements. The primary outcome was the Gross Motor Function Measure-66 score. Secondary outcomes were motion analysis of walking, full-day step counts, motor evoked potentials from transcranial magnetic stimulation, and patellar tendon reflexes.
Limitations. Inter-individual heterogeneity in the severity of the stroke and behavioral differences are substantial but measurable. Differences in intervention delivery and assessment scoring are minimized by standardization and training.
Conclusions. The intervention, contrary to current practice, could change physical therapy interventions for children with perinatal stroke.
Using AFP Levels to Aid in Pre-Operative Planning for Sonographically Ambiguous Teratomas [6OP]
Authors: Walker Andrea , Castaneda Antonio , Mostofizadeh Sayedamin , Emily Prendergast , Cortessis Victoria K. , Holschneider Christine 
Published: May 2017

INTRODUCTION:
To define a pre-operative serum alpha feto-protein (AFP) value that distinguishes mature cystic teratomas (MCT) from immature teratomas (IT) among ultrasonographically ambiguous teratomas.

METHODS:
In a three-institution retrospective cohort study, patients undergoing surgery for MCT or IT were reviewed to identify those with ambiguous teratomas on preoperative ultrasound. The receiver-operating curve (ROC) optimized to institution A preoperative AFP levels was used to determine a cut-off value distinguishing benign from malignant tumors, which was validated at institutions B and C.

RESULTS:
Of 379 Institution A patients, 347 had a sonographic diagnosis of MCT (pathology confirmed). 30 had sonographically ambiguous teratomas and preoperative AFP levels; pathology revealed 25 MCT and 5 IT. Median serum AFP for MCT [1.5 ng/mL (IQR 1.05 -2.45 ng/mL)] was significantly lower than for IT [27.0 ng/mL (IQR 8.65 - 193.7 ng/mL)] (p less than 0.001). Area under the ROC was greatest (0.984) for using an AFP cut-off value of 4.15 ng/mL, which was 100% sensitive and 92.0% specific for IT. In the validation cohort from Institutions B and C (N = 1,091; 157 sonographically ambiguous and AFP drawn; 144 MCT, 13 IT), preoperative AFP exceeded 4.15 ng/mL in 10 of 13 with malignant tumors and 13 of 144 with benign tumors, yielding 77% sensitivity, 91% specificity, 44% PPV and 98% NPV. The 3 cases with AFP below the discriminatory zone had grade 1 stage 1A disease.

CONCLUSION:
An AFP cut-off of 4.15ng/mL offers excellent NPV and sensitivity, reducing instances in which a general gynecologist would unknowingly operate on a malignant tumor.
Lower Limb Compression Prevents Hypotension After Epidural in Labor Patients: A Randomized Controlled Trial [7OP]
Authors: Steinmetz Margaret M. , Shelton James A. , Watt Stacey A. , Johnson Jeffrey R. 
Published: May 2017

INTRODUCTION:
Approximately 30% of patients who elect to have epidural anesthesia during labor experience hypotension, potentially causing complications for both mother and fetus. We evaluated whether lower limb compression at the time of epidural would decrease maternal hypotension.

METHODS:
A multisite randomized controlled trial was conducted. Term, singleton parturients requesting epidural were recruited and randomized into one of three arms: control, thrombo-embolic deterrent (TED) stockings, or sequential compression device (SCD). Hospital protocol was followed for intravenous fluid hydration prior to epidural placement. Blood pressures were evaluated at 1, 5, 15, 30, 45, and 60 minutes following administration of epidural bolus. Hypotension was defined as a decrease in either systolic or diastolic blood pressure of greater than 20% from baseline, which was the average of the three blood pressures obtained prior to the epidural. Analysis was based on intention to treat.

RESULTS:
Data from 71 patients were analyzed: 27 controls, 21 TEDs, and 23 SCDs. Demographics were similar across groups. Hypotension occurred in 66.7% of patients in the control arm compared to 52.4% of patients in the TED arm, and 30.4% in the SCD arm (P=.038). Logistic regression controlling for clinical site, delivery method, maternal age, gestational age at delivery, and maternal BMI did not affect the results.

CONCLUSION:
Lower limb compression using SCDs significantly decreased the incidence of maternal hypotension in laboring patients receiving epidural anesthesia. Our incidence of maternal hypotension was higher than what is reported in the literature.
Do 30-Day Postpartum Readmissions Rates Vary by Site of Care for Vulnerable Patients? [9OP]
Authors: Ranjit Anju , Zogg Cheryl , Witkop Catherine , Little Sarah , Haider Adil H. , Robinson Julian N. 
Published: May 2017

INTRODUCTION:
To determine 30-day readmission rates following delivery in the United States, assess for access-based differences in readmission rates, and determine if differences vary by site of care.

METHODS:
We used Nationwide Readmissions Database to identify deliveries between January-October 2013. We categorized Medicaid, uninsured, and low-income patients as “vulnerable” and ranked hospitals by the proportion of vulnerable patients that they served. Differences in 30-day readmissions among higher (more than 74th percentile) versus lower (1-74th) vulnerable patient-serving hospitals were compared using multivariable logistic regression. Models adjusted for differences in patient demographics, comorbidities, pregnancy risk-status, type of deliveries, and hospital characteristics.

RESULTS:
A total of 1,392,622 deliveries were included, weighted to represent 3,932,181 deliveries nationwide. In 2013, 136 women/10,000 deliveries (1.4%) were readmitted within 30 post-discharge days. The most common reasons for readmissions were wound infection(n=1733, 9.1%), endometritis (n=1454, 7.7%), and hypertension(n=1181, 6.2%). A total of 732,441 (52.6%) deliveries were to vulnerable patients; 505,807 (36.3%) received care at hospitals managing a higher proportion of such patients. 30-day readmissions were higher among vulnerable patients (1.5% vs. 1.1%, OR [95% CI]: 1.39 [1.33-1.45]).

CONCLUSION:
Vulnerable patients experienced higher 30-day readmission rates, regardless of site of care. While differences were marginally pronounced at hospitals managing a lower proportion of vulnerable patients, the ubiquitousness of the finding across institutions speaks to the pervasive need to address disparities in perinatal care.
Secondary Benefits of CenteringPregnancy Care in an Adolescent Pregnant Population [10OP]
Authors: Roussos-Ross Dikea , O'Shea Tina , Ramos Mariana 
Published: May 2017

INTRODUCTION:
CenteringPregnancy (CP), a group prenatal care model, has reported improved birth-related outcomes, specifically in preterm deliveries. Limited data exists, however, reporting additional benefits seen in patients receiving prenatal care within this model.

METHODS:
With IRB approval, a chart review was conducted comparing pregnancy related outcomes in patients who received care through the CenteringPregancy model vs the Traditional Prenatal Care model in our Women's Health Clinics at UF Health. A total of 20 patients, ages 18-21 received care via CP from March 2015–May 2016. These patients were compared to a random sample of 20 patients ages 18-21 who received care via the Traditional model from January 2014-December 2014.

RESULTS:
Although both groups showed similar breastfeeding initiation rates (95% CP vs 90% Control), the CP group showed significantly more breastfeeding at 6 weeks postpartum (42% vs 20%). Additionally, the CP group had significantly more adolescent patients elect LARC (32% vs 0%). Finally, the CP group showed significantly higher rates of immunizations in pregnancy: Influenza vaccine rates (45% CP, vs 30% Control) and TDaP vaccine rates (60% CP vs 35% Control).

CONCLUSION:
The CenteringPregnancy model may offer additional benefits in adolescent mothers, specifically: breastfeeding, contraception, and vaccination rates. Offering adolescent mothers group care allows for greater time with their provider, which in turn may lead to increased knowledge and understanding of health and pregnancy related outcomes. The outcomes noted in this study are promising and additional data may reveal that CenteringPregnancy may offer improved overall care in this population.
Long-Term Consequences of Extended Endocrine Strategies for Premenopausal Breast Cancer [11OP]
Authors: Kwon Janice S. , Pansegrau Gary , Nourmoussavi Melica , Hammond Geoffrey , Carey Mark 
Published: May 2017

INTRODUCTION:
Breast cancer is the most common cancer among women in America, and gynecologists often encounter these women in their practice. After 5 years of adjuvant tamoxifen, women with ER+ breast cancer benefit from extended endocrine therapy, either with tamoxifen or an aromatase inhibitor (AI). For premenopausal women, ovarian ablation (OA) is required before starting an AI, but there is concern about the long-term outcomes (osteoporosis, heart disease) and costs of OA.

METHODS:
A Markov Monte Carlo simulation model estimated the costs and benefits of extended endocrine strategies in a hypothetical cohort of premenopausal women with ER+ cancer: (1) no further treatment; (2) tamoxifen for 5 years; (3) OA followed by AI for 5 years (OA/AI). Effectiveness was measured in years of life expectancy gain. Monte Carlo simulation estimated the number of adverse events and deaths from each strategy in the American population over a 40-year horizon.

RESULTS:
Tamoxifen for 5 more years yielded a higher average discounted life expectancy gain than OA/AI (16.57 vs. 16.34 years) at lower average cost ($2,976 vs. $10,150). For 18,000 ER+ premenopausal women diagnosed annually, the simulation estimated 12,526, 11,508, and 10,289 deaths after no further treatment, tamoxifen and OA/AI respectively, but another 2,139 deaths from long-term consequences of OA. According to sensitivity analyses, women had to be over 50.8 years of age before OA/AI became cost-effective.

CONCLUSION:
As extended endocrine therapy for premenopausal ER+ breast cancer, another 5 years of tamoxifen is more effective and less costly than ovarian ablation followed by 5 years of aromatase inhibitor.
Post-partum Management of Chorioamnionitis: Efficacy of Continuation of Antibiotics After Delivery [13OP]
Authors: Goldberg Aaron , Malik Meher 
Published: May 2017

INTRODUCTION:
Chorioamnionitis, or infection of the fetal membranes, effects approximately 10% of laboring women. Antibiotic treatment prior to delivery reduces both maternal and neonatal infectious complications. Continuation of maternal treatment after delivery is standard practice yet has not been demonstrated effective at reducing post-partum endometritis or other complications and is based on expert opinion.

METHODS:
Following IRB approval, between March 2012 and October 2013, women delivering vaginally with chorioamnionitis meeting inclusion criteria and consenting to participate were randomized to receive antibiotics until afebrile for 24 hours following delivery or a single antibiotic dose following delivery. Outcomes include endometritis, post-partum fever, maternal length of stay, and total doses of antibiotics. Chorioamnionitis diagnosis and treatment was standardized across both groups. A systematic review of existing research was also conducted given the limited number of participants.

RESULTS:
Forty-six women were randomized, 23 in each group. Groups were similar in demographic and intrapartum characteristics. Those receiving a single antibiotic dose after delivery reviewed fewer total antibiotic doses (3.00 ± 1.00 vs. 7.04 ± 1.15, p less than 0.001). There were no significant differences for length of stay and no participants experienced treatment failures requiring resumption of antibiotics for endometritis or fevers. Four existing randomized trials with similar design including 305 women delivering vaginally also demonstrated no difference in postpartum complications among treatment groups.

CONCLUSION:
Antibiotics may be safely stopped following vaginal delivery in women with chorioamnionitis. Current practice of prolonged antibiotic treatment is not evidence based and should be reconsidered. Further research is warranted.
Comparing Diagnosis, Management, and Outcomes of Fetal Growth Restriction Using Hadlock vs. Fenton Growth Curves [14OP]
Authors: Rajaram Akhila M. , Strassberg Emmie R. , Paglia Michael J. , Bringman Jay J. , Neubert A. George , Mackeen A. Dhanya , Schuster Meike 
Published: May 2017

INTRODUCTION:
Fetal growth restriction (FGR) is defined as an estimated fetal weight (EFW)

METHODS:
All singleton pregnancies at our institution were included that were diagnosed with FGR per Hadlock between 6/2014-5/2015. The EFWs were applied to the Fenton curve to reassess the diagnosis of FGR, as well as the number of abnormal umbilical artery Doppler (UAD) measurements, incidence of small for gestational age (SGA) neonates (birth weight

RESULTS:
A 77.3% reduction in FGR diagnosis was noted from 110 pregnancies identified by Hadlock to 25 pregnancies identified by Fenton. If the Fenton curve was applied, the number of iatrogenic deliveries for FGR would have been 19 (instead of 62) in the cohort (p=0.0243). There were no differences in the number of absent or reversed UAD identified, SGA deliveries, antenatal steroid administered or NICU admission. There were no stillbirths/neonatal deaths in our cohort.

CONCLUSION:
By applying the Fenton growth curve, the number of FGR diagnoses is reduced without a resultant increase in perinatal morbidity; additionally, the burden of antenatal testing, ultrasounds, and iatrogenic deliveries is also reduced.