bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the longitudinal risk of social vigilance on atherosclerosis: study protocol for the North Texas Heart Study
Authors: Ruiz John M , Taylor Daniel J , Uchino Bert N , Smith Timothy W , Allison Matthew , Ahn Chul , Johnson Jillian J , Smyth Joshua M 
Published: August 2017

IntroductionPsychosocial factors are increasingly recognised as important determinants of cardiovascular disease risk. The North Texas Heart Study aims to understand the mechanisms responsible for this association with a focus on social vigilance (ie, scanning the environment for social threats). There is also growing interest in supplementing traditional methods (eg, survey assessment of psychosocial risk paired with cross-sectional and longitudinal health outcomes) with daily or repeated momentary assessment of psychosocial factors. However, there are relatively few longitudinal studies directly comparing these approaches with hard endpoints.Methods and analysisThe North Texas Heart Study proposes a longitudinal measurement burst design to examine psychosocial determinants of subclinical atherosclerosis. A sample of 300 healthy community participants, stratified by age and gender, will complete survey measures, as well as 2 days of ecological momentary assessment at baseline and at a 2-year follow-up. A range of psychosocial and behavioural factors, objective biomarkers, as well as carotid intima-media thickness (cIMT) will be assessed at both time points. Unadjusted and adjusted models will evaluate cross-sectional associations and determinants of change in the cIMT.Ethics and disseminationThe Institutional Review Board at the study coordinating institute (University of North Texas) has approved this study. Positive, negative or inconclusive primary and ancillary findings will be disseminated in scientific journals and conferences.
Thermodynamics of Schwarzschild–Beltrami–de Sitter black hole
Authors: Liu Hang , Meng Xin-He 
Published: August 2017

In this paper, we investigate the thermodynamical properties of Schwarzschild–Beltrami–de Sitter (S–BdS) black hole introduced by Yan et al. in 2013 by introducing inertial Beltrami coordinates to traditional non-inertial Schwarzschild–de Sitter (S–dS) metric which is the exact static spherical symmetry solution of Einstein equation with a positive cosmological constant [Formula: see text]. Based on this new metric, we compute entropy on all horizons and we give the entropy bound of the black hole. Hawking temperatures are calculated by considering a perturbation to entropy relations due to that the spacetime described by these inertial coordinates is no longer a stationary spacetime in which surface gravity related to Hawking temperature is defined well on killing horizon. We also get the Smarr relations and the first law of thermodynamics. We find that the S–BdS black hole seems to have similar thermodynamical properties to S–dS black hole in the comparison between their corresponding thermodynamical quantities, although the new black hole metric is described by inertial coordinates which exclude the effects of inertial force.
Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence
Authors: Bainor Anthony J. , Deng Fang-Ming , Wang Yu , Lee Peng , Cantor David J. , Logan Susan K. , David Gregory 
Published: August 2017

Abstract
Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in human prostate adenocarcinoma correlating with upregulation of its target genes. Our results suggest a tumor suppressor function for SIN3B that limits prostate adenocarcinoma progression, with potential implications for the use of SIN3B and its target genes as candidate diagnostic markers to distinguish indolent from aggressive disease. Cancer Res; 77(19); 5339–48. ©2017 AACR.
Genomic Alterations in Circulating Tumor DNA from Diverse Cancer Patients Identified by Next-Generation Sequencing
Authors: Schwaederle Maria , Chattopadhyay Ranajoy , Kato Shumei , Fanta Paul T. , Banks Kimberly C. , Choi In Sil , Piccioni David E. , Ikeda Sadakatsu , Talasaz AmirAli , Lanman Richard B. , Bazhenova Lyudmila , Kurzrock Razelle 
Published: August 2017

Abstract
Noninvasive genomic profiling of tumors may be possible with next-generation sequencing (NGS) of blood-derived circulating tumor DNA (ctDNA), but proof of concept in a large cohort of patients with diverse cancers has yet to be reported. Here we report the results of an analysis of plasma-derived ctDNA from 670 patients with diverse cancers. The tumors represented in the patient cohort were mainly gastrointestinal (31.8%), brain (22.7%), or lung (20.7%). ctDNA obtained from most patients [N = 423 (63%)] displayed at least one alteration. The most frequent alterations seen, as characterized mutations or variants of unknown significance, occurred in TP53 (32.5% of patients), EGFR (13%), KRAS (12.5%), and PIK3CA (9.1%); for characterized alterations, 30.7% (TP53), 7.6% (EGFR), 12.2% (KRAS), and 7.7% (PIK3CA). We found that 32% of brain tumors had at least one ctDNA alteration. Head and neck tumors were independently associated with a higher number of alterations in a multivariable analysis (P = 0.019). Notably, 320/670 (48%) of patients displayed potentially actionable alterations, with 241 patients possible candidates for on-label or off-label treatment with an FDA-approved drug. Several illustrations of the clinical utility of the information obtained for improving treatment of specific patients is provided. Our findings demonstrate the feasibility and impact of genomic profiling of tumors by ctDNA NGS, greatly encouraging broader investigations of the application of this technology for precision medicine in cancer management. Cancer Res; 77(19); 5419–27. ©2017 AACR.
The Rac GTPase in Cancer: From Old Concepts to New Paradigms
Authors: Kazanietz Marcelo G. , Caloca Maria J. 
Published: August 2017

Abstract
Rho family GTPases are critical regulators of cellular functions that play important roles in cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their regulators, is a hallmark of cancer and contributes to the tumorigenic and metastatic phenotypes of cancer cells. This review examines the multiple mechanisms leading to Rac1 hyperactivation, particularly focusing on emerging paradigms that involve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 degradation, and mislocalization of Rac signaling components. The unexpected pro-oncogenic functions of Rac GTPase-activating proteins also challenged the dogma that these negative Rac regulators solely act as tumor suppressors. The potential contribution of Rac hyperactivation to resistance to anticancer agents, including targeted therapies, as well as to the suppression of antitumor immune response, highlights the critical need to develop therapeutic strategies to target the Rac pathway in a clinical setting. Cancer Res; 77(20); 5445–51. ©2017 AACR.
Use of Antihypertensive Medications and Risk of Adverse Breast Cancer Outcomes in a SEER–Medicare Population
Authors: Chen Lu , Chubak Jessica , Boudreau Denise M. , Barlow William E. , Weiss Noel S. , Li Christopher I. 
Published: August 2017

Abstract
Background: It is unclear if use of common antihypertensive medications influences the risk of adverse breast cancer outcomes.
Methods: Using the linked Surveillance, Epidemiology and End-Results (SEER)–Medicare database, we identified 14,766 women between ages 66 and 80 years diagnosed with incident stage I/II breast cancer between 2007 and 2011. Medicare Part D data were obtained to characterize women's post-cancer use of various antihypertensive medications. Outcomes included a second breast cancer event (SBCE; a composite outcome defined as the first of a recurrence or a second contralateral primary breast cancer), breast cancer recurrence, and breast cancer–specific mortality. Time-varying Cox proportional hazard models were used to estimate hazard ratios (HR) and their associated 95% confidence intervals (CI).
Results: There were 791 SBCEs, 627 breast cancer recurrences, and 237 breast cancer deaths identified over a median follow-up of 3 years. Use of diuretics (n = 8,517) after breast cancer diagnosis was associated with 29% (95% CI, 1.10–1.51), 36% (95% CI, 1.14–1.63) and 51% (95% CI, 1.11–2.04) higher risks of a SBCE, recurrence, and breast cancer death, respectively. Compared with nonusers, β-blockers users (n = 7,145) had a 41% (95% CI, 1.07–1.84) higher risk of breast cancer death. Use of angiotensin II receptor blockers, calcium channel blockers and angiotensin-converting enzyme inhibitors were not associated with risks of breast cancer outcomes.
Conclusions: Use of diuretics and β-blockers may be associated with increased risk of breast cancer outcomes among older women.
Impact: Most antihypertensive medications are safe with respect to breast cancer outcomes, but more research is needed for diuretics and β-blockers. Cancer Epidemiol Biomarkers Prev; 26(11); 1603–10. ©2017 AACR.
Impact of Primary Tracheoesophageal Puncture on Outcomes after Total Laryngectomy
Authors: Panwar Aru , Militsakh Oleg , Lindau Robert , Coughlin Andrew , Sayles Harlan , Rieke Katherine R. , Lydiatt William , Lydiatt Daniel , Smith Russell 
Published: August 2017

ObjectivesTo identify differences in postoperative wound complications associated with a primary tracheoesophageal puncture (TEP) at the time of laryngectomy versus no TEP.Study DesignRetrospective review of large national data set.SettingAcademic and nonacademic health care facilities in United States, contributing de‐identified, risk‐adjusted clinical data to the American College of Surgeons National Surgical Quality Improvement Program.Subjects and MethodsThe National Surgical Quality Improvement Program data set for years 2006 to 2012 identified 430 patients who underwent total laryngectomy with or without a primary TEP. Patients who underwent a TEP at the time of laryngectomy (n = 68) were compared with patients who underwent laryngectomy without a TEP (n = 362). Postoperative wound complications and secondary outcomes, including medical complications and length of hospitalization, were compared between the groups.ResultsThe incidence of “superficial” and “deep or organ space” surgical site infection, medical complications, return to the operating room, and length of hospitalization were similar between the groups. Patients in the TEP group had a higher overall wound complication rate (relative risk, 2.02; 95% CI = 1.06‐3.84; attributable risk, 8.17%; number needed to harm, 12).ConclusionsPerformance of a primary TEP concurrent to total laryngectomy contributed to a small increase in attributable risk for overall wound complications but did not add substantial risk for “superficial” or “deep or organ space” surgical site infection, medical complications, or increased burden for resource utilization. These data may help inform patient choice and physician recommendations for primary alaryngeal speech rehabilitation.
Red blood cells in thrombosis
Authors: Byrnes James R. , Wolberg Alisa S. 
Published: August 2017

Abstract
Red blood cells (RBCs) have historically been considered passive bystanders in thrombosis. However, clinical and epidemiological studies have associated quantitative and qualitative abnormalities in RBCs, including altered hematocrit, sickle cell disease, thalassemia, hemolytic anemias, and malaria, with both arterial and venous thrombosis. A growing body of mechanistic studies suggests that RBCs can promote thrombus formation and enhance thrombus stability. These findings suggest that RBCs may contribute to thrombosis pathophysiology and reveal potential strategies for therapeutically targeting RBCs to reduce thrombosis.
An AMPK-dependent regulatory pathway in tau-mediated toxicity
Authors: Galasso Alessia , Cameron Charles S. , Frenguelli Bruno G. , Moffat Kevin G. 
Published: August 2017

Neurodegenerative tauopathies are characterized by accumulation of hyperphosphorylated tau aggregates primarily degraded by autophagy.The 5'AMP-activated protein kinase (AMPK) is expressed in most cells, including neurons. Alongside its metabolic functions, it is also known to be activated in Alzheimer's brains, phosphorylate tau and be a critical autophagy activator. Whether it plays a neurotoxic or neuroprotective role remains unclear. Complexly in tauopathies, while stress conditions can result in AMPK activation enhancing tau-mediated toxicity, AMPK activation is not always concomitant with autophagic induction.Using a Drosophila in vivo quantitative approach, we have analysed the impact of AMPK and autophagy on tau-mediated toxicity, recapitulating the AMPK-mediated tauopathy condition: increased tau phosphorylation, without corresponding autophagy activation.We have demonstrated that AMPK, binding to and phosphorylating tau at Ser-262, a site reported to facilitate soluble tau accumulation, affects its degradation. This phosphorylation results in exacerbation of tau toxicity and is ameliorated via rapamycin-induced autophagy stimulation.Our findings support the development of combinatorial therapies effective at reducing tau toxicity targeting tau phosphorylation and AMPK-independent autophagic induction. The proposed in vivo tool represents an ideal readout to perform preliminary screening for drugs promoting this process.
Anatomy’s a drag: Queer fashion and camp performance in Leigh Bowery’s Birth Scenes
Authors: Galvin Kristen 
Published: August 2017

Abstract
Leigh Bowery is often remembered for his outlandish fashion design, controversial performance art and alternative rock band, Minty. Bowery’s performances in his self-fashioned ‘looks’ were genre- and gender-bending. His costumes were often transformative prosthetics and imagined anatomies that acted as fantastical yet temporary body modification. While Bowery’s incessantly shifting body is addressed, this article focuses on Bowery’s notorious Birth Scenes (1992−94). Manifesting in a variety of iterations, Bowery literally wore another person, who happened to be his wife, as drag for simulated birth onstage. And importantly, the performances occurred at queer venues and events during the ongoing AIDS crisis of the early 1990s. Through visual cultural analysis, this article argues that Bowery manipulated camp tactics of artifice, incongruity, appropriation and humour, to challenge normativity and capitalism, and furthermore; to test cultural assumptions about drag performance, which was then having a distinct cultural moment in the early 1990s. This article explores Bowery’s Birth Scenes to understand how queer fashion and performance combine to explode notions of the body and embedded sociocultural norms of sexuality, gender and consumerism.
Community of difference: The liminal spaces of the Bingodisiac Orchestra
Authors: Snake-Beings Emit 
Published: August 2017

Abstract
The Bingodisiac Orchestra, a nomadic improvised community music project without fixed membership, is explored in this article as a case study examining the ‘open participatory’ aspects of Do-it-Yourself (DiY) sound culture. Established by the researcher in 2002, the ‘orchestra’ is an audio-visual event that attempts to break down barriers between diverse musical forms while also engaging in various strategies to maximize the interaction between audience and performer. In doing so, Stephen Duncombe’s idea of the ‘community of difference’ is employed, whereby the orchestra becomes a practice that embodies a de-centralized approach to both social organization and the organization of sound. Other concepts discussed in this article include the ‘fairground effect’, a strategy of the Bingodisiac Orchestra to de-centralize the production of sound through the use of liminal spaces traditionally ignored in music performance: creating a more participatory space for the performance, which allows different styles of music to be simultaneously and spontaneously incorporated into the performance. In this way, liminal space and the ‘community of difference’ are identified as being a part of the process of creating musical communities that encourage improvised music that is ‘free’ of any particular style: altering the focus of musicians from the need to find a common ground as a basis for their sound improvisations, while also enabling the temporary construction of a community sound experience.
Drum circles and community music: Reconciling the difference
Authors: Laurila Kelly , Willingham Lee 
Published: August 2017

Abstract
This article is a contribution to reconciliation between Indigenous and Settler peoples in Canada through the creation of space for Indigenous voices within the practice of community music. Colonization and policies to assimilate Indigenous peoples have had devastating impacts and have served to undermine their communal way of life and cultural identities. Many urban Indigenous peoples are searching for ways to ‘re-member,’ ‘re-connect,’ and ‘re-claim’ a sense of community and connection to their traditions. This article takes anchor in the stories of urban Indigenous youth and women and what their drum circle means to them.
Musomagic: Artist-led personal development programmes for youth as viewed through a Community Music Therapy lens
Authors: Baker Felicity A , Jeanneret Neryl , Kelaher Margaret 
Published: August 2017

Abstract
Large (80+ participants) artist-led programmes with young people frequently take place in school settings, and the artist has limited background knowledge of those attending. This study examined the components of an artist-led programme to identify the nuanced behaviours of artists and volunteer helpers that support musical engagement, personal and social development, and promote social capital. From an analysis of videos and interviews, we examine the activities and outcomes of artistled programmes as viewed through the lens of Community Music Therapy (CoMT). We found that the programmes were ecological, ethics-driven and participatory, and espoused activism, which are core features of CoMT thinking. We found that within this model, there was importance placed on the youth taking the music outside formal spaces and sharing it with the community in public places such as local cafes, residential care facilities and police stations. The role of the artist-facilitator goes beyond preparing the youth for this experience and extends to preparing the local community – an ecological approach.
Voices from devotional ritual: Practitioners’ unity of purpose to building community in araquio musical tradition
Authors: Ibarra Florante P. 
Published: August 2017

Abstract
This ethnographic-phenomenological study explores the holistic nature of araquio tradition. Araquio, a verse play on the search of the holy cross, is an indigenous folk theatre in the town of Peñaranda, province of Nueva Ecija, Philippines, that has survived for over 100 years. The orihinal (script) utilized the local poetic stylized delivery of verses, conventionalized movements, choreographed sword fights, songs and dances with distinct live musical accompaniment played by the community band. Araquio’s musical tradition suggests a culturally specific metaphor that has overshadowed its diminishing tradition. Constructed in the framework of music as social behaviour, I investigated araquio’s musical tradition as the product of the social behaviour of a specific group of practitioners and how music-making builds a community. Eleven adult practitioners participated in this enquiry. An ethnographic method was employed using participant-observation and an informal semistructured interview script. This oral tradition created a process of social structures and situations stemmed initially from a self-imposed initiative that had become a template to a group or community-building setting. The metaphorical iconicity of the musical tradition, through unspoken meanings such as gender roles and religious beliefs, offered certain unarticulated significance.
Re-voicing: Community choir participation as a medium for identity formation amongst people with learning disabilities
Authors: Hassan Nedim 
Published: August 2017

Abstract
This article examines findings from ethnographic research with the ReVoice choir project in North-West England. ReVoice was a community choir that consisted of members from two charitable organizations and the author of this article. A number of ReVoice’s members were adults with learning disabilities and part of the choir’s remit was to produce music that would feature in a film about hate crime perpetuated against people with disabilities. In the light of debates regarding the politics of identity for people with disabilities, this article illustrates how the formation of the choir, the rehearsal process and the choir performances constituted a distinctive cultural context that afforded people significant opportunities to develop an alternative, empowered sense of self in concert with others.
I am Ìyálóde of Ẹtì still: A Yoruba Duchess of Malfi
Authors: Hopkins Lisa 
Published: August 2017

Abstract
This article examines Débò Olúwatûmínú's Ìyálóde of Ẹtì (An Original Adaptation of The Duchess of Malfi By John Webster), produced by Utopia Theatre in Leeds, Sheffield and Doncaster in autumn 2016. Olúwatûmínú's play takes the story of The Duchess of Malfi and transposes it to nineteenth-century Yorùbáland. This inevitably leads to major changes to names and situations, yet there are some even more striking similarities and continuities. The essay compares Ìyálóde of Ẹtì with Chinua Achebe’s Things Fall Apart ([1958] 1996) and Chimamanda Ngozi Adichie’s Half of a Yellow Sun ([2006] 2014) to argue that the interest in twinning found in both these three texts and The Duchess of Malfi itself is played out in the relationship between adaptation and original: Ìyálóde of Ẹtì may take its inspiration from Webster, but it, like its heroine, is itself, and even if it knows that the precolonial Yorùbáland it shows us is trembling on the edge of extinction, it also shows us that the customs and stories of that land still have vibrancy and force. Ìyálóde of Ẹtì may be Kehinde to The Duchess of Malfi’s Taiwo, but it is a second-born with power, and it is Ìyálóde of Ẹtì still.
Academe and academy: Kenneth Branagh’s Love’s Labour’s Lost
Authors: Wardle Janice 
Published: August 2017

Abstract
This article argues that Kenneth Branagh’s film adaptation of Shakespeare’s Love’s Labour’s Lost (2000), although not a commercial or a critical success when released, continues to raise issues pertinent to contemporary adaptation studies. By investigating how Shakespeare’s ‘academe’ is represented through the idiom of a different kind of ‘Academy’, that of the Hollywood musical of the 1930s/1940s, we can uncover tensions created by the opposition of high and low culture, and the intermingling of the cinematic and the theatrical. In this film adaptation of a play, the relationship between the cinematic and theatrical is further complicated through the model of the early Hollywood musical, which itself seeks, through its inbuilt conventions, to maintain a connection with live theatre and its community. Although Branagh’s adaptation may be deemed a failed experiment, it is representative, in its exploitation of the interaction between the cinematic and theatrical, of a continuing, complex conversation between the genres, exemplified by the use of cinematic techniques in the theatre, and the broadcasting of live theatre into cinemas.