bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical and Catalytic Properties of Nanozymes for Colorimetric Biosensors: Advantages, Limitations, and Perspectives
Authors: Panferov Vasily G. , Liu Juewen 
Published: September 2024

AbstractDetection of colorimetric signals is commonly used in various analytical methods and for testing in non‐laboratory and resource‐limited settings. The performance of colorimetric assays is largely based on nanoparticles and their unique optical properties. Multifunctional nanoparticles combining optical and enzyme‐like catalytic properties—known as nanozymes—hold great promise for analytical applications as signal‐generating labels. However, the extensive focus on the catalytic properties leaves their unique optical properties overlooked. In this article, the use of the optical and catalytic properties of nanozymes is reviewed for analytical applications relying on the inherent optical properties of nanozymes, the colorimetric detection of a catalytically‐formed product, and colorimetric changes of nanoparticles caused by the catalytically‐formed product. The impact of the extinction coefficient of nanozymes and reaction products, as well as the kinetic parameters of nanozymes on the sensitivity and limit of detection of assays, are quantitatively evaluated. Finally, the existing limitations and prospects of nanozymes for colorimetric biosensors are summarized.
Enhanced Piezocatalytic Water Splitting by Platinum‐Decorated Barium Titanate
Authors: Subramaniam Guru Prasanna Ganapathi , Billing Matthew , Nguyen Hoang‐Duy P. , Nguyen Nguyen‐Phuong , Le Bao‐Ngoc T. , Park Seonghyeok , Sathasivam Sanjayan , Pham Thuy‐Phuong T. , Dunn Steve 
Published: September 2024

AbstractPiezocatalysis has emerged as a promising field of research that uses mechanical energy to drive a chemical change. There is growing evidence that piezocatalysts can perform challenging chemical conversions from organic transformations to water splitting. A key challenge to piezocatlaysis is mitigating the inherent high relative permittivity of a ferroelectric material. This high permittivity restricts the transfer of carriers required for a chemical reaction to occur and reduces the reaction rate. Here the concept of producing a co‐catalyst system is taken to enhance carrier mobility increasing the observed reaction rate. The study highlights the importance of determining the sonochemical and piezocatalytic contributions to catalysis. The combination of a Pt metal co‐catalyst with BaTiO3 through a simple solid‐state method led to a four fold increase in the rate of H2 production compared to BaTiO3 and sonochemical reactions in the absence of a catalyst. BaTiO3/Pt is found to exhibit stable piezocatalytic performance over 12 h. Where there is a deviation from steady‐state water splitting, it is shown that this is due to mechanical removal of Pt rather than a phase change in the catalyst system. This work confirms the additive benefits of hybrid materials for improving piezocatalytic processes.
VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location
Authors: Liu Wenwen , Wang Kehan , Lin Yuting , Wang Lu , Jin Xin , Qiu Yuexin , Sun Wenya , Zhang Ling , Sun Yan , Dou Xiaowei , Luo Shiming , Su Youqiang , Sun Qingyuan , Xiang Wenpei , Diao Feiyang , Li Jing 
Published: September 2024

AbstractAsynchronous nuclear and cytoplasmic maturation in human oocytes is believed to cause morphological anomalies after controlled ovarian hyperstimulation. Vacuolar protein sorting 34 (VPS34) is renowned for its pivotal role in regulating autophagy and endocytic trafficking. To investigate its impact on oocyte development, oocyte‐specific knockout mice (ZcKO) are generated, and these mice are completely found infertile, with embryonic development halted at 2‐ to 4‐cell stage. This infertility is related with a disruption on autophagic/mitophagic flux in ZcKO oocytes, leading to subsequent failure of zygotic genome activation (ZGA) in derived 2‐cell embryos. The findings further elucidated the regulation of VPS34 on the activity and subcellular translocation of RAS‐related GTP‐binding protein 7 (RAB7), which is critical not only for the maturation of late endosomes and lysosomes, but also for initiating mitophagy via retrograde trafficking. VPS34 binds directly with RAB7 and facilitates its activity conversion through TBC1 domain family member 5 (TBC1D5). Consistent with the cytoplasmic vacuolation observed in ZcKO oocytes, defects in multiple vesicle trafficking systems are also identified in vacuolated human oocytes. Furthermore, activating VPS34 with corynoxin B (CB) treatment improved oocyte quality in aged mice. Hence, VPS34 activation may represent a novel approach to enhance oocyte quality in human artificial reproduction.
Imperfection‐Enabled Strengthening of Ultra‐Lightweight Lattice Materials
Authors: Ding Junhao , Ma Qingping , Li Xinwei , Zhang Lei , Yang Hang , Qu Shuo , Wang Michael Yu , Zhai Wei , Gao Huajian , Song Xu 
Published: September 2024

AbstractLattice materials are an emerging family of advanced engineering materials with unique advantages for lightweight applications. However, the mechanical behaviors of lattice materials at ultra‐low relative densities are still not well understood, and this severely limits their lightweighting potential. Here, a high‐precision micro‐laser powder bed fusion technique is dveloped that enables the fabrication of metallic lattices with a relative density range much wider than existing studies. This technique allows to confirm that cubic lattices in compression undergo a yielding‐to‐buckling failure mode transition at low relative densities, and this transition fundamentally changes the usual strength ranking from plate > shell > truss at high relative densities to shell > plate > truss or shell > truss > plate at low relative densities. More importantly, it is shown that increasing bending energy ratio in the lattice through imperfections such as slightly‐corrugated geometries can significantly enhance the stability and strength of lattice materials at ultra‐low relative densities. This counterintuitive result suggests a new way for designing ultra‐lightweight lattice materials at ultra‐low relative densities.
Enhanced Lithium Extraction from Brines: Prelithiation Effect of FePO4 with Size and Morphology Control
Authors: Zhao Xiaoyu , Yang Shuo , Song Xiuli , Wang Yushuang , Zhang Hui , Li Muhan , Wang Yanfei 
Published: September 2024

AbstractExtracting lithium resources from seawater and brine can promote the development of the new energy materials industry. The electrochemical method is green and efficient. Iron phosphate (FePO4) crystal, with its 1D ion channel, holds significant potential as a primary lithium extraction electrode material. Li+ encounters a substantial concentration disadvantage in brines, and the co‐intercalation of Na+ diminishes Li+ selectivity. To address this issue, this work enhances the energy barrier for Na+ insertion through prelithiation strategies applied to the 1D channels of FePO4 crystal, thereby improving Li+ selectivity, and further investigating the prelithiation effect with particle size and morphology control. The results indicate that the Li(4C‐40%)FePO4// Activated carbon(AC) system enhances selectivity of lithium. The Li(4C‐40%)FePO4 with size diameter of 2500 nm demonstrates an energy consumption of 0.79 Wh mol−1 and a purity of 97.94% for lithium extraction at a unit lithium extraction of 5.93 mmol g−1 in simulated brine. Li(4C‐40%)FePO4‐nanoplates demonstrate the most optimal lithium extraction performance among the three morphologies due to their lamellar structure's short ion diffusion path in the [010] channel, favoring Li+ diffusion. The diffusion energy barriers of Li+ and Na+ are calculated using Density Functional Theory (DFT) before and after prelithiation, showing good agreement with experimental results.
PTBP1 Regulates DNMT3B Alternative Splicing by Interacting With RALY to Enhance the Radioresistance of Prostate Cancer
Authors: He Haixia , Zhou Qianghua , Zhang Yangjie , Li Yi , Ding Lin , Shen Ting , Liu Sen , Peng Shengmeng , Huang Ming , Zhou Hua , Cheng Liang , Xie Ruihui , Zhang Qiang , Lu Junlin , Li Liting , Yang Jing , Bai Shoumin , Lin Tianxin , Chen Xu 
Published: September 2024

AbstractRadiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression. Nonetheless, the role of splicing factors in radioresistance remains largely unexplored in PCa. Here, 23 splicing factors that are differentially expressed between PCa and adjacent normal tissues across multiple public PCa databases are identified. Among those genes, polypyrimidine tract binding protein 1 (PTBP1) is significantly upregulated in PCa and is positively associated with advanced clinicopathological features and poor prognosis. Gain‐ and loss‐of‐function experiments demonstrate that PTBP1 markedly reinforces genomic DNA stability to desensitize PCa cells to irradiation in vitro and in vivo. Mechanistically, PTBP1 interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) associated with lethal yellow protein homolog (RALY) and regulates exon 5 splicing of DNA methyltransferase 3b (DNMT3B) from DNMT3B‐S to DNMT3B‐L. Furthermore, upregulation of DNMT3B‐L induces promoter methylation of dual‐specificity phosphatase‐2 (DUSP2) and subsequently inhibits DUSP2 expression, thereby increasing radioresistance in PCa. The findings highlight the role of splicing factors in inducing aberrant splicing events in response to radiotherapy and the potential role of PTBP1 and DNMT3B‐L in reversing radioresistance in PCa.
Titania‐Based Coral‐Structured Solar Absorber Coating with Improved Scalability and Durability at High Temperature
Authors: Guo Yifan , Tsuda Kaoru , Mohsenzadeh Milad , Hosseini Sahar , Murakami Yasushi , Coventry Joe , Torres Juan F. 
Published: September 2024

AbstractSolar energy harvesting and storage are essential in the future mix of renewable energy technologies. Hierarchical coral‐structured coatings have been shown to yield high solar absorptance in concentrating solar thermal (CST) systems. However, interfacial delamination and scalability challenges owing to material complexity pose significant hurdles for the widespread industrial adoption of these hierarchical CST coatings. Here, a coral‐structured coating is proposed whose black pigments are strongly bonded by titania, which is a material that mitigates interfacial delamination. Importantly, this coating follows a facile deposition procedure suitable for large‐scale solar receivers. The drone‐deposited coating inhibits cation diffusion and maintains a stable solar absorptance of even after long‐term (3000 h) high‐temperature () aging. The scalability of developed coating represents a substantial advancement in the implementation of light‐trapping enhancement and maintenance approaches across a wide range of CST applications.
2D to 3D Magnetism in Synthetic Micas
Authors: Rosas‐Huerta José Luis , Wolber Jonas , Minaud Claire , Fabelo Oscar , Ritter Clemens , Mentré Olivier , Arévalo‐López Ángel M. 
Published: September 2024

AbstractFe‐based mica minerals usually display two opposing magnetic ground states, either they behave as spin‐glasses or as layered ferrimagnets. No definite reason has been proposed as an explanation for this duality. This conundrum is unraveled by comparing the synthetic micas KFe3[MGe3]O10X2 with M═Fe and Ga, X═OH− and F−. Neutron diffraction demonstrates a 2D to 3D magnetic transition in KFe3[FeGe3]O10(OH)2 while just hints or no order at all are observed for the fluorides with M═Fe and Ga respectively. The 3D transition is triggered by the presence of iron in the intralayer tetrahedra. DFT+U calculations show that the magnetic exchange couplings between the previously believed solely magnetic octahedral layers would otherwise be frustrated without this intralayer iron.
Combinatorial Optimization of Metal‐Insulator‐Insulator‐Metal (MIIM) Diodes With Thickness‐Gradient Films via Spatial Atomic Layer Deposition
Authors: Alshehri Abdullah H. , Asgarimoghaddam Hatameh , Delumeau Louis‐Vincent , Nguyen Viet Huong , Ali AlRasheed , Aljaghtham Mutabe , Alamry Ali , Ozyigit Dogu , Yavuz Mustafa , Musselman Kevin P. 
Published: September 2024

AbstractMetal‐insulator‐insulator‐metal (MIIM) diodes with thickness‐gradient films for the insulator layers are fabricated for the first time. Spatially varying atmospheric‐pressure chemical vapor deposition is used to deposit ZnO and Al2O3 films with orthogonal gradient directions, producing 414 MIIM diodes with 414 different ZnO/Al2O3 film‐thickness combinations on a single substrate for combinatorial and high‐throughput optimization. The nm‐scale ZnO/Al2O3 films are printed in only 2 min and the entire device fabrication takes 7 h, which is much less than conventional approaches for investigating many insulator‐thickness combinations. Rapid identification of the optimal thickness combination is demonstrated; high‐performance diodes (asymmetry = 227, nonlinearity = 13.1, and responsivity = 12 A/W) are observed when a trap‐assisted tunneling mechanism is dominant for insulator thicknesses of 3.4–4.4 nm (ZnO) and 7.4 nm (Al2O3).
Recent Advances in the Large‐Scale Production of Photo/Electrocatalysts for Energy Conversion and beyond
Authors: Li Jinhao , Li Zixian , Sun Qiuhong , Wang Yujun , Li Yang , Peng Yung‐Kang , Li Ye , Zhang Ce , Liu Bin , Zhao Yufei 
Published: September 2024

AbstractPhotocatalysis and electrocatalysis have emerged as promising technologies for addressing the energy crisis and environmental issues. However, the widespread application of these technologies is hampered by the challenge of scaling up the production of photo/electrocatalysts that are not only highly active and stable but also cost‐effective and environmentally benign. This review delves into the latest advancements in the large‐scale synthesis of photo/electrocatalysts. The factors to be considered in the large‐scale production of catalysts are discussed first. The synthesis methods for batch preparation of photo/electrocatalysts are then comprehensively introduced, with a thorough discussion of their respective advantages and limitations. Moreover, the data analysis via machine learning techniques, which not only accelerates the identification and refinement of potential new catalysts but also offers insights for enhancing the high‐throughput synthesis of catalysts, is introduced in detail. Then the representative examples are presented to illustrate the applications of large‐scale catalysts in the field of industrial‐level photo/electrocatalysis. Finally, the challenges and prospects in the development of large‐scale production of photo/electrocatalysts are discussed. By bridging the gap between laboratory research and industrial application, this review aims to provide a reference for the future of large‐scale preparation of photo/electrocatalysts in sustainable energy conversion and beyond.
Crystal Step‐Induced Uniform and Rapid Deposition on Zinc Anodes
Authors: Yan Mengdie , Zhao Xuesong , Chen Diancheng , Li Wanxia , Liu Liqi , Sun Yang , Jiao Shuhong , Pan Huilin 
Published: September 2024

AbstractAqueous Zn‐ion batteries have emerged as promising candidates for large‐scale energy storage owing to their high safety and low cost. However, dendrite growth and side reactions compromise the stability of the Zn anode in practical applications. Here, a novel Zn anode featuring well‐designed crystal steps along the (002) facets, referred to as Step‐Zn is introduced. The intersections of the (002) and (100) planes in these crystal steps create preferential adsorption sites for Zn2⁺ ions, promoting initial electro‐epitaxial growth of Zn that uniformly covers the crystal steps. This process effectively regulates subsequent Zn deposition, ensuring fast reaction kinetics and smooth morphology without dendrite formation. Consequently, the unique Step‐Zn anode exhibits excellent cycle life over 6000 times at 3 mA cm−2 and low greatly reduced polarization voltage under high areal currents and capacities. Integrated with activated carbon (AC) cathode, the Step‐Zn||AC full cell demonstrates excellent durability over 10 000 cycles at 5 A g−1. This work offers valuable insights into controlling Zn deposition modes by engineering the surface microstructure of Zn anodes with greatly extended cycling stability.
Global optimization for large‐scale water network synthesis based on dynamic partition and adaptive bound tightening
Authors: Zhou Wenjin , Liu Linlin , Du Jian 
Published: September 2024

AbstractThe synthesis of large‐scale integrated water networks is typically formulated as nonconvex mixed‐integer quadratic constrained programming (MIQCP) or QCP problems. With the complexity arising from bilinear terms in modeling mass flows of contaminants and binary variables representing the presence of units or streams, numerous local optima exist, thus presenting a significant optimization challenge. This study introduces a deterministic global optimization algorithm based on mixed‐integer programming (MIP) to tackle such problems. The approach involves dynamically strengthening the relaxed problems to converge towards the original problems. A simultaneous partition strategy is proposed combining locally uniform division with dynamic partitioned variables choosing. Furthermore, several adaptive bound contraction schemes are introduced to efficiently manage the size of the relaxed problems, assisting in accelerating the solution process. The algorithm's effectiveness and robustness are demonstrated with a large test set, showing superior performance compared to commercial solvers specifically on MIQCP problems.
Perspectives and Insights Into Phenylketonuria: Patient Narratives About the Early Years Following Newborn Screening
Authors: Holmes Brittany M. , Hollander Suzanne , Sacharow Stephanie 
Published: September 2024

ABSTRACTNewborn screening for Phenylketonuria (PKU) began in 1963, and since then knowledge and treatment recommendations have evolved. In the decades following newborn screening for PKU, individual and family experiences varied widely. We present narratives by people living with PKU during these years, including individuals actively following in PKU clinic and those who have been out of PKU clinic for many years. These stories describe different individual experiences, including diet discontinuation in childhood, changing treatment guidelines, and new treatments that have become available.
Fluorine‐Lodged High‐Valent High‐Entropy Layered Double Hydroxide for Efficient, Long‐Lasting Zinc‐Air Batteries
Authors: Li Bo , Zhong Jing , Wang Hao , Gu Jialun , Lyu Fucong , Chen Shengmei , Wu Haikun , Li Lanxi , Zhi Chunyi , Lu Jian , Li Yang Yang 
Published: September 2024

AbstractEfficient and stable bifunctional oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) catalysts are urgently needed to unlock the full potential of zinc‐air batteries (ZABs). High‐valence oxides (HVOs) and high entropy oxides (HEOs) are suitable candidates for their optimal electronic structures and stability but suffer from demanding synthesis. Here, a low‐cost fluorine‐lodged high‐valent high‐entropy layered double hydroxide (HV‐HE‐LDH) (FeCoNi2F4(OH)4) is conveniently prepared through multi‐ions co‐precipitation, where F− are firmly embedded into the individual hydroxide layers. Spectroscopic detections and theoretical simulations reveal high valent metal cations are obtained in FeCoNi2F4(OH)4, which enlarge the energy band overlap between metal 3d and O 2p, enhancing the electronic conductivity and charge transfer, thus affording high intrinsic OER catalytic activity. More importantly, the strengthened metal‐oxygen (M−O) bonds and stable octahedral geometry (M−O(F)6) in FeCoNi2F4(OH)4 prevent structural reorganization, rendering long‐term catalytic stability. Furthermore, an efficient three‐phase reaction interface with fast oxygen transportation was constructed, significantly improving the ORR activity. ZABs assembled with FeCoNi2F4(OH)4@HCC (hydrophobic carbon cloth) cathodes deliver a top performance with high round‐trip energy efficiency (61.3 % at 10 mA cm−2) and long‐term stability (efficiency remains at 58.8 % after 1050 charge–discharge cycles).
Photoinduced Pd‐Catalyzed Direct Sulfonylation of Allylic C−H Bonds
Authors: Mukherjee Kallol , Cheung Kelvin Pak Shing , Gevorgyan Vladimir 
Published: September 2024

AbstractAllylic sulfones are valuable motifs due to their medicinal and biological significance and their versatile chemical reactivities. While direct allylic C−H sulfonylation represents a straightforward and desirable approach, these methods are primarily restricted to terminal alkenes, leaving the engagement of the internal counterparts a formidable challenge. Herein we report a photocatalytic approach that accommodates both cyclic and acyclic internal alkenes with diverse substitution patterns and electronic properties. Importantly, the obtained allylic sulfones can be readily diversified into a wide range of products, thus enabling formal alkene transposition and all‐carbon quaternary center formation through the sequential C−H functionalization.
An Insight Into Experimental and Theoretical Investigation of Structure, Photophysical Property by ESIPT Processes and Biological Activities of Schiff Base Copper Complex
Authors: Rama Iravatham , Nathiya Singaravel , Panneerselvam Murugesan , Subashini Annamalai , Costa Luciano T. , Jeeva Gothandam , Achiraman Shanmugam , Dhinesh Kumar 
Published: September 2024

ABSTRACTA novel Schiff base (BSSMO) and its copper complex have been synthesized, and their structure was delineated using single crystal XRD studies. Computational techniques were used to design and evaluate BSSMO‐based luminophores, revealing a significant intramolecular hydrogen bond within the molecule. Understanding ESIPT is crucial for optimizing photophysical and luminophore properties of organic molecules, especially for advancing optoelectronic devices. The study also explored the mechanisms of GSIPT and ESIPT for these BSSMO‐based luminophores using transition state theory, charge distribution, molecular orbital analysis, and quantum theory of atoms in molecules. Results advocated that BSSMO‐L2 exhibits higher absorption compared with BSSMO‐L1 and the same trend is observed in emission spectral studies. However, the intensity of enol emissions in BSSMO‐L2 is lower than that of keto (BSSMO‐L3) emissions and the S1 (Keto form) emission of BSSMO‐L3 shows significantly larger values, making it attractive for optoelectronic devices. The findings offer valuable insights for the development of ESIPT emitters with distinct photophysical properties. The in silico antidiabetic study of BSSMO‐L2 explores the interaction with PPAR‐γ protein, revealing a moderate affinity and stable complex, enhancing its bio‐potential for future applications. The in vitro anticancer study of Cu‐BSSMO‐L2 complex shows a potential anticancer effect through mitochondrial and extrinsic death receptor mediated pathways. These insights contribute to the design of novel benzenesulfonamide‐based bioactive molecules.