bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong conservatism in leaf anatomical traits and their multidimensional relationships with leaf economic traits in grasslands under different stressful environments
Authors: Liu Xinrui , Wang Xue , Zhu Jiang , Wang Xiaochun , Chen Kaixi , Yuan Yanqi , Yang Xue , Mo Weiyi , Wang Ruili , Zhang Shuoxin 
Published: September 2024

Abstract
Background
Plant traits and plant adaptive strategies have been affected by the increasing intensity and severity of environmental changes. Given the uncertainty surrounding future environmental conditions, investigating plant trait variations under various stresses is crucial for unraveling plant survival strategies. Leaf anatomical traits are closely responsible for plants’ photosynthesis, respiration and transpiration. However, knowledge of how the multi-species leaf anatomical traits varied in extremely and moderately stressful environments is limited. Our objective was to compare the variation of leaf anatomic traits and adaptation strategies in two different stressful regions of the Qinghai-Tibet Plateau (TP) and Mongolian Plateau (MP) of China.

Methods
We sampled ten sites in each of the two regions (MP and TP) along an environmental gradient. Seven leaf anatomical traits and two leaf economic traits were measured for all leaf samples. Leaf anatomical traits include the traits related to leaf physiological processes (mesophyll thickness (MT), palisade tissue thickness (PT), spongy tissue thickness (ST), palisade-spongy tissue thickness ratio (PST) and epidermal thickness (ET)) and the traits related to trait construction investment (epiderm-leaf thickness ratio (ET/LT) and mesophyll-leaf thickness ratio (MT/LT)). Leaf economic traits include specific leaf area (SLA) and leaf nitrogen content (LN).

Results
The results revealed that leaf anatomical traits in the TP exhibited greater phylogenetic conservation with thicker structures, being less susceptible to environmental impacts than those in the MP. Additionally, the leaf anatomical and economic traits decoupled both in the MP and TP.

Conclusion
These findings highlight that plants adopt diverse strategies to cope with extremely and moderately environmental stresses, but multidimensional trait patterns are generally favored in stressful environments.
The regulatory landscape of interacting RNA and protein pools in cellular homeostasis and cancer
Authors: Gallardo-Dodd Carlos J. , Kutter Claudia 
Published: September 2024

AbstractBiological systems encompass intricate networks governed by RNA-protein interactions that play pivotal roles in cellular functions. RNA and proteins constituting 1.1% and 18% of the mammalian cell weight, respectively, orchestrate vital processes from genome organization to translation. To date, disentangling the functional fraction of the human genome has presented a major challenge, particularly for noncoding regions, yet recent discoveries have started to unveil a host of regulatory functions for noncoding RNAs (ncRNAs). While ncRNAs exist at different sizes, structures, degrees of evolutionary conservation and abundances within the cell, they partake in diverse roles either alone or in combination. However, certain ncRNA subtypes, including those that have been described or remain to be discovered, are poorly characterized given their heterogeneous nature. RNA activity is in most cases coordinated through interactions with RNA-binding proteins (RBPs). Extensive efforts are being made to accurately reconstruct RNA-RBP regulatory networks, which have provided unprecedented insight into cellular physiology and human disease. In this review, we provide a comprehensive view of RNAs and RBPs, focusing on how their interactions generate functional signals in living cells, particularly in the context of post-transcriptional regulatory processes and cancer.
Validation of factor structures of the Drinking Motives Questionnaire among the Czech young and adult general population
Authors: Kážmér Ladislav , Csémy Ladislav , Šíba Ondřej 
Published: September 2024

Abstract
Background
Alcohol use is one of the leading public health concerns in the Czech Republic. Drinking motives play a vital role in both initiation and subsequent alcohol use. A revised version of the self-report Drinking Motives Questionnaire (DMQ-R) has been proposed to assess these motives. The present study aims to validate the DMQ-R in the Czech general population.

Methods
A total sample of 1,784 Czech participants completed a national survey. For the analysis, only a sub-sample of the past 12 months alcohol users was used: N = 1,123; 52.8% male; mean (SD) age = 40.2 (13.3). Drinking motives were assessed by the adopted Czech version of the DMQ-R. Both confirmatory (CFA) and exploratory factor analysis (EFA) were conducted to examine the factorial structure of the instrument. The age of the participant was additionally considered in the analysis (15–24 years as opposed to 25–64 years).

Results
The CFA supported the four-factor model in the 25–64 age group. The analysis supported the construct validity of the Social, Conformity, and Coping factors. The Enhancement factor retained only two items and was found to refer more to a domain of ‘Pleasant Feeling’. For the 15–24 age group, the hypothesised four-factor structure was not corroborated.

Conclusions
The Czech version of the DMQ-R was found to be a reliable measurement tool of the Social, Conformity, and Coping motives. Future research should investigate the dimensionality of the instrument items presumed to correspond to the Enhancement motives. This should be conducted particularly among adolescents and young adults aged 15–24 years, where administering the DMQ-R with a large enough sample is also needed.
DNA damage response in breast cancer and its significant role in guiding novel precise therapies
Authors: Li Jiayi , Jia Ziqi , Dong Lin , Cao Heng , Huang Yansong , Xu Hengyi , Xie Zhixuan , Jiang Yiwen , Wang Xiang , Liu Jiaqi 
Published: September 2024

AbstractDNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic instability, and tumor development. Conversely, DDR deficiency is an intrinsic feature of tumors that underlies their response to treatments that inflict DNA damage. In this review, we systematically explore various mechanisms of DDR, the rationale and research advances in DDR-targeted drugs in breast cancer, and discuss the challenges in its clinical applications. Notably, poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated favorable efficacy and safety in breast cancer with high homogenous recombination deficiency (HRD) status in a series of clinical trials. Moreover, several studies on novel DDR-related molecules are actively exploring to target tumors that become resistant to PARP inhibition. Before further clinical application of new regimens or drugs, novel and standardized biomarkers are needed to develop for accurately characterizing the benefit population and predicting efficacy. Despite the promising efficacy of DDR-related treatments, challenges of off-target toxicity and drug resistance need to be addressed. Strategies to overcome drug resistance await further exploration on DDR mechanisms, and combined targeted drugs or immunotherapy will hopefully provide more precise or combined strategies and expand potential responsive populations.
Plant investigation and the impact on earthen site soil properties in the east city wall of the Sanxingdui site
Authors: Yao Xue , Zhao Fan , Hao Jianfeng , Wang Yanwu , Hu Rui 
Published: September 2024

Abstract
In southern China, vegetation on exposed earthen sites serves not only to mitigate erosion but also alters their visual appearance, leading to biodeterioration. However, how plants influence the properties of earthen sites is virtually unknown. This study undertook an ecological investigation of the original habitat in the east city wall of the Sanxingdui site, analyzing its soil properties and investigating plant-soil interactions. Research findings indicate that existing plant communities are not conducive to biodiversity nor site presentation. Plants exert a direct influence within a vertical range extending 0–40 cm beneath the site; root content correlates negatively with soil pH value but positively with organic matter content. The herbaceous community (E-2 and E-3) exhibits higher clay content than the arbor community (E-1) within this range. The above conclusions exhibit statistical significance. This study offers a scientific elucidation of the ecological parameters governing plant communities concerning the conservation of earthen sites, and provides an initial influence range of plant communities and biodegradation on the east city wall of the Sanxingdui sites, thereby revealing the technical potential for employing plants as a soft capping for earthen sites in the open air from the function method.
Integration of the Natural World Heritage conservation and development of buffer zone agroforestry: from scientometrics insights and implications for the Karst World Heritage
Authors: Fang Ruonan , Xiong Kangning , Ding Yuping , Wang Dongnan 
Published: September 2024

Abstract
Currently, global warming, invasive alien species and tourism development pose major threats to Natural World Heritage sites, and the strengthening of conservation methods and management programs in buffer zones is urgent for the sustainable development of sites. Agroforestry, as a nature-based solution, not only promotes the buffer zone to effectively maintain the Outstanding Universal Value of the heritage site, but also balances the relationship between the conservation of the heritage site and the economic development of the buffer zone, and effectively enhances the protection of the buffer zone in response to various threats. However, there is currently a lack of comprehensive understanding of research trends, research focuses, and recent developments, regarding the conservation of natural heritage sites and buffer zone agroforestry development. Therefore, this study utilized the Scopus database along with Excel and Bibliometrix software to conduct a bibliometric analysis and explore and visualize popular research topics and foreword issues related to Natural World Heritage conservation and buffer zone agroforestry development. We discuss the current publication trends and quantity, keyword and abstract word frequencies, thematic maps and evolutions, journal productivity, national publication outputs, collaboration relationships, and contributing institutions. The research shows that the relationship between biodiversity conservation and agroforestry has been the focus of research in the field since 1992, and the development of agroforestry has contributed to biodiversity conservation in heritage sites. However, there have been fewer studies addressing the geomorphic and aesthetic value of agroforestry conservation, and little attention has been paid to buffer zone development. Based on this, this manuscript suggests that in the future, emphasis should be placed on the linkage between the development of buffer zones and heritage conservation, especially in the Karst World Heritage Sites with ecologically fragile, and that the role of agroforestry development in buffer zones should be strengthened in the promotion of ecological balance and sustainable development of the sites, to provide scientific references for the conservation and development of other geoheritage sites around the globe.
Assessment of shear strength of fine-grained and coarse-grained soil using actual EPB-TBM operating data
Authors: Samadi Hanan , Hassanpour Jafar , Rostami Jamal 
Published: September 2024

AbstractThe necessity of predicting geotechnical parameters in soft ground tunnelling is crucial for selecting the appropriate tunnel boring machine (TBM), evaluating the operating limit of earth pressure balance (EPB) machines’ parameters, and ensuring the safety and efficiency of TBMs during tunnel construction. In this research, various EPB operating parameters such as cutterhead torque, thrust force, chamber pressure, and cutterhead rotation speed (RPM) were utilized to estimate geotechnical parameters like friction angle (φ) and shear strength (τ) for engineering geological units ET1 to ET5 (fine-grained and coarse-grained soils) along the tunnels route, which serve as indicative units for the entire tunnels path. Statistical methods and computational techniques, namely support vector regression (SVR) and feed-forward neural network (FFNN), were trained using EPB operating parameters and geotechnical data from Tehran metro line 6—southern extension sector (TML-SE6) and the East–west section of line 7, Tehran metro project (TML-EW7). A comprehensive dataset comprising borehole logging results along the tunnel path was gathered, with 85% of the data randomly selected for training and the remaining 15% reserved for model testing. Various loss functions and statistical metrics were employed to evaluate the accuracy and precision of the method. The results of the proposed models demonstrate satisfactory and reliable accuracy of the approaches.
Biopolymer-based composites for sustainable energy storage: recent developments and future outlook
Authors: Patra Niranjan , Ramesh Prathipati , Donthu Vaishnavi , Ahmad Akil 
Published: September 2024

Abstract
Over the past decade, biopolymers made from renewable resources like plants, algae, seashell waste, and seaweed have become increasingly popular as industries strive to reduce their environmental pollution without compromising socioeconomic growth. Biopolymers are often regarded as a significant alternative to conventional materials due to their low weight, great strength, stiffness, biostability, and non-toxicity. Therefore, industries are beginning to adopt the use of biopolymers, including those dealing with packaging, agriculture, automobiles, healthcare, as well as energy harvesting. Supercapacitors and batteries are two examples of electrochemical devices for energy storage that can be made using bespoke biopolymers and their composites. Although biopolymers’ potential uses are restricted, they are nevertheless useful when combined with other materials to create composites. This boosts the electrochemical efficiency of the biologically active molecules and also enhances their inherent physical features. This review focuses on recent developments, specifically the use of diverse biopolymers and composites for batteries and supercapacitor applications, followed by future perspectives.
Asymptomatic Plasmodium falciparum and HBV coinfections among inmates at Owo Correctional Facility, Nigeria
Authors: Ajakaye Oluwaremilekun Grace , Omidele Abiola A. 
Published: September 2024

Abstract
Background
Malaria and hepatitis B are significant public health infections in Nigeria. Coinfection with both pathogens is common where both diseases are endemic. Epidemiological surveys are essential for determining the burden of diseases and possible coinfection with multiple pathogens in vulnerable populations. There has been a lack of reports on HBV/malaria coinfection, particularly among marginalized groups in Ondo State. Thus, we used malaria microscopy and the HBsAg serological test to examine the prevalence of asymptomatic malaria parasitemia and HBV infections respectively among inmates at the Nigerian Correctional Center in Owo, Ondo State, Nigeria.

Results
Out of the 126 prisoners and staff members who were evaluated, 20.6% and 7.9% tested positive for malaria and HBV infections, respectively. It was discovered that 1.6% of the individuals were coinfected with malaria and HBV. Plasmodium falciparum was the only malaria species recovered in malaria-infected individuals. Except for HBV, where gender was found to differ considerably with the proportion of HBV infection, variations in single infections with either pathogen did not vary with demographic characteristics.

Conclusion
We suggest that the prison system should be considered in healthcare programs to improve the health of inmates.
Rare diseases: What rheumatologists need to know?
Authors: do Nascimento Renan Rodrigues Neves Ribeiro , Piotto Daniela Gerent Petry , Freire Eutilia Andrade Medeiros , de Souza Neves Fabricio , Sztajnbok Flavio Roberto , Bica Blanca Elena Rios Gomes , Pinheiro Frederico Augusto Gurgel , Kozu Katia Tomie , Pereira Ivanio Alves , Azevedo Valderilio Feijo , Cordeiro Rafael Alves , Giardini Henrique Ayres Mayrink , Franco Marco Túlio Muniz , de Fátima Fernandes Carvalho Margarida , Rosa-Neto Nilton Salles , Perazzio Sandro Félix 
Published: September 2024

AbstractAlthough the terms “rare diseases” (RD) and “orphan diseases” (OD) are often used interchangeably, specific nuances in definitions should be noted to avoid misconception. RD are characterized by a low prevalence within the population, whereas OD are those inadequately recognized or even neglected by the medical community and drug companies. Despite their rarity, as our ability on discovering novel clinical phenotypes and improving diagnostic tools expand, RD will continue posing a real challenge for rheumatologists. Over the last decade, there has been a growing interest on elucidating mechanisms of rare autoimmune and autoinflammatory rheumatic diseases, allowing a better understanding of the role played by immune dysregulation on granulomatous, histiocytic, and hypereosinophilic disorders, just to name a few. This initiative enabled the rise of innovative targeted therapies for rheumatic RD. In this review, we explore the state-of-the art of rare RD and the critical role played by rheumatologists in healthcare. We also describe the challenges rheumatologists may face in the coming decades.
Protected areas, drought, and grazing regimes influence fire occurrence in a fire-prone Mediterranean region
Authors: Kirkland Máire , Atkinson Philip W. , Aliácar Sara , Saavedra Deli , De Jong Mark C. , Dowling Thomas P. F. , Ashton-Butt Adham 
Published: September 2024

Abstract
Background
Extreme fire seasons in the Mediterranean basin have received international attention due to the damage caused to people, livelihoods, and vulnerable ecosystems. There is a body of literature linking increasingly intense, large fires to a build-up of fuel from rural land abandonment exacerbated by climate change. However, a better understanding of the complex factors driving fires in fire-prone landscapes is needed. We use a global database based on the MODIS Fire CCI51 product, and the Greater Côa Valley, a 340,000-ha area in Portugal, as a case study, to investigate the environmental drivers of fire and potential tools for managing fires in a landscape that has undergone changing agricultural and grazing management.

Results
Between 2001 and 2020, fires burned 32% (1881.45 km2) of the study area. Scrublands proportionally burnt the most, but agricultural land and forests were also greatly impacted. The risk of large fires (> 1 km2) was highest in these land cover types under dry conditions in late summer. Areas with higher sheep densities were more likely to burn, while cattle density had no apparent relationship with fire occurrence. There was also a 15% lower probability of a fire occurring in protected areas.

Conclusion
Future climatic changes that increase drought conditions will likely elevate the risk of large fires in the Mediterranean basin, and abandoned farmland undergoing natural succession towards scrubland will be at particularly high risk. Our results indicate that livestock grazing does not provide a simple solution to reducing fire risk, but that a more holistic management approach addressing social causes and nature-based solutions could be effective in reducing fire occurrence.
Planning cities with nature for sustainability transformations — a systematic review
Authors: Harms Philip , Hofer Maeve , Artmann Martina 
Published: September 2024

AbstractThe future coexistence of human and nonhuman nature on an urban planet is at risk. A crucial lever is the transformation of human-nature relationships in and through cities. Urban planning as a sustainability intervention has the potential to reconnect cities with nature. To shed light on transformative potentials of urban planning in the context of human-nature connections, we conducted a systematic literature review. We analysed 71 empirical studies from Europe published between 2016 and 2022. We characterised the research using qualitative analysis, and applied the leverage point perspective as the main focus to identify blind spots and future research needs. Our review reveals a highly interdisciplinary field with research focus on transformation through planning, while issues of transformation in planning tend to receive less attention. Furthermore, the studies rather deal with shallow leverage points for sustainability transformations both in terms of system levels and human-nature connections. In order to unlock the potential of urban planning, future research should pay more attention to the inner dimensions of planning and human-nature connections in cities. Furthermore, research should be more concerned with the visionary modes of urban planning, e.g. by discussing what is (not) desirable in the future.
Livestock farming and women empowerment in rural Bangladesh: a mixed method approach
Authors: Nath Toma Deb , Rahman Md. Sadique , Biswas Arindam , Juice Rahat Ahmed 
Published: September 2024

Abstract

Background
In Bangladesh, livestock farming is not only a major source of animal protein, but it also provides opportunities for women to contribute to household income. Therefore, this study was undertaken to identify the empowerment status of women livestock farmers, factors influencing women's participation in livestock farming and its impact on women's empowerment.

Methods
The study was conducted in the Mymensingh district (administrative unit) of Bangladesh, due to the active participation of women in livestock farming activities. A total of 200 women were surveyed between May to November 2018. Additionally, prior to the final survey, 02 Focus Group Discussions (FGDs) were performed to gain insight into the context of the study areas. Furthermore, a total of 12 semi-structured in-depth interviews were performed with 12 experienced women livestock farmers to collect data regarding the challenges they encounter in livestock farming. Women empowerment was measured using four domains: decision-making process, ownership of assets, social and political awareness, and freedom of mobility. Descriptive statistics, and Heckman's endogenous treatment effect model were applied to analyze the data.

Results
The results revealed that majority (75%) of women who are involved in livestock farming had a medium level of empowerment. Women's decision to participate in livestock farming was positively influenced by farm size, knowledge, extension contact, and training. According to the average treatment effect on the treated (ATT) value, the empowerment status of women is 16 points higher among participants in livestock farming compared to non-participants. Furthermore, women in rural areas face several obstacles such as economic issues and inadequate marketing facilities, which may prevent them from engaging in livestock farming.

Conclusions
Educating women through raising awareness and providing training is warranted because there is a notable disparity in the empowerment status of women who are and are not involved in livestock farming. This will help women improve their social awareness, decision-making capacity, and mobility. Livestock initiatives that encourage women's involvement could be generated by various rural-focused organizations.