bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic, Environmental, and Disease-Associated Correlates of Vitamin D Status in Children with CKD
Authors: Doyon Anke , Schmiedchen Bettina , Sander Anja , Bayazit Aysun , Duzova Ali , Canpolat Nur , Thurn Daniela , Azukaitis Karolis , Anarat Ali , Bacchetta Justine , Mir Sevgi , Shroff Rukshana , Yilmaz Ebru , Candan Cengiz , Kemper Markus , Fischbach Michel , Cortina Gerard , Klaus Günter , Wuttke Matthias , Köttgen Anna , Melk Anette , Querfeld Uwe , Schaefer Franz ,   for the 4C Study Consortium
Published: June 2016

Background and objectives
Vitamin D deficiency is endemic in children with CKD. We sought to investigate the association of genetic disposition, environmental factors, vitamin D supplementation, and renal function on vitamin D status in children with CKD.

Design, setting, participants, & measurements
Serum 25-hydroxy-vitamin D, 1,25-dihydroxy-vitamin D, and 24,25-dihydroxy-vitamin D concentrations were measured cross-sectionally in 500 children from 12 European countries with CKD stages 3–5. All patients were participants of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease Study, had CKD stage 3–5, and were age 6–18 years old. Patients were genotyped for single-nucleotide polymorphisms in the genes encoding 25-hydroxylase, vitamin D binding protein, 7-dehydrocholesterol reductase, and 24-hydroxylase. Associations of genetic status, season, local solar radiation, oral vitamin D supplementation, and disease-associated factors with vitamin D status were assessed.

Results
Two thirds of patients were vitamin D deficient (25-hydroxy-vitamin D <16 ng/ml). 25-Hydroxy-vitamin D concentrations varied with season and were twofold higher in vitamin D–supplemented patients (21.6 [14.1] versus 10.4 [10.1] ng/ml; P<0.001). Glomerulopathy, albuminuria, and girls were associated with lower 25-hydroxy-vitamin D levels. 24,25-dihydroxy-vitamin D levels were closely correlated with 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D (r=0.87 and r=0.55; both P<0.001). 24,25-dihydroxy-vitamin D concentrations were higher with higher c-terminal fibroblast growth factor 23 and inversely correlated with intact parathyroid hormone. Whereas 25-hydroxy-vitamin D levels were independent of renal function, 24,25-dihydroxy-vitamin D levels were lower with lower eGFR. Vitamin D deficiency was more prevalent in Turkey than in other European regions independent of supplementation status and disease-related factors. Single-nucleotide polymorphisms in the vitamin D binding protein gene were independently associated with lower 25-hydroxy-vitamin D and higher 24,25-dihydroxy-vitamin D.

Conclusions
Disease-related factors and vitamin D supplementation are the main correlates of vitamin D status in children with CKD. Variants in the vitamin D binding protein showed weak associations with the vitamin D status.
Read Range Sensitivity of Embedded RFID Tags in Commercial Tires
Authors: Wei Terence E. , Wilson Paul B. 
Published: June 2016

ABSTRACT

Radiofrequency (RFID) identification is a commonly used technology in retail stores, highway toll payment transceivers, payment cards for mass transit systems, electronic access cards for office buildings, and many other applications. The use of RFID in tires can increase efficiencies of tracking manufacturing, distribution, retreading, and tire usage, resulting in reduced costs. Previous research has shown difficulty in obtaining a useful read range from RFID tags in tires, although most of these studies have involved passenger car tires that do not have steel body plies. In this work, commercially available RFID tags with helical dipole antennas were embedded into commercial tires of four different sizes. The difference in size between the largest and smallest tire used was 10%. These commercial tires have steel belts as well as steel body plies. Other than dimensions, all of the tires had identical tire constructions and used the same rubber compounds. Identical tags were embedded at the same location in all tires. Measurements were performed on multiple tires per size, which show that the read range of the helical dipole antenna has a high sensitivity to tire size. The sensitivity of the read range due to tire size is undesirable, because it means that sufficient read range may not be achieved in all tire constructions with the same tag.
Effects of Locomotor Exercise Intensity on Gait Performance in Individuals With Incomplete Spinal Cord Injury
Authors: Leech Kristan A. , Kinnaird Catherine R. , Holleran Carey L. , Kahn Jennifer , Hornby T. George 
Published: June 2016

AbstractBackgroundHigh-intensity stepping practice may be a critical component to improve gait following motor incomplete spinal cord injury (iSCI). However, such practice is discouraged by traditional theories of rehabilitation that suggest high-intensity locomotor exercise degrades gait performance. Accordingly, such training is thought to reinforce abnormal movement patterns, although evidence to support this notion is limited.ObjectiveThe purposes of this study were: (1) to evaluate the effects of short-term manipulations in locomotor intensity on gait performance in people with iSCI and (2) to evaluate potential detrimental effects of high-intensity locomotor training on walking performance.DesignA single-day, repeated-measures, pretraining-posttraining study design was used.MethodsNineteen individuals with chronic iSCI performed a graded-intensity locomotor exercise task with simultaneous collection of lower extremity kinematic and electromyographic data. Measures of interest were compared across intensity levels of 33%, 67%, and 100% of peak gait speed. A subset of 9 individuals participated in 12 weeks of high-intensity locomotor training. Similar measurements were collected and compared between pretraining and posttraining evaluations.ResultsThe results indicate that short-term increases in intensity led to significant improvements in muscle activity, spatiotemporal metrics, and joint excursions, with selected improvements in measures of locomotor coordination. High-intensity locomotor training led to significant increases in peak gait speed (0.64–0.80 m/s), and spatiotemporal and kinematic metrics indicate a trend for improved coordination.LimitationsMeasures of gait performance were assessed during treadmill ambulation and not compared with a control group. Generalizability of these results to overground ambulation is unknown.ConclusionsHigh-intensity locomotor exercise and training does not degrade, but rather improves, locomotor function and quality in individuals with iSCI, which contrasts with traditional theories of motor dysfunction following neurologic injury.
Flower power and the mustard bomb: Comparative analysis of gene and genome duplications in glucosinolate biosynthetic pathway evolution in Cleomaceae and Brassicaceae
Authors: van den Bergh Erik , Hofberger Johannes A. , Schranz M. Eric 
Published: June 2016

PREMISE OF THE STUDY:Glucosinolates (GS) are a class of plant secondary metabolites that provide defense against herbivores and may play an important role in pollinator attraction. Through coevolution with plant‐interacting organisms, glucosinolates have diversified into a variety of chemotypes through gene sub‐ and neofunctionalization. Polyploidy has been of major importance in the evolutionary history of these gene families and the development of chemically separate GS types. Here we study the effects of polyploidy in Tarenaya hassleriana (Cleomaceae) on the genes underlying GS biosynthesis.METHODS:We established putative orthologs of all gene families involved in GS biosynthesis through sequence comparison and their duplication method through calculation of synonymous substitution ratios, phylogenetic gene trees, and synteny comparison. We drew expression data from previously published work of the identified genes and compared expression in several tissues.KEY RESULTS:We show that the majority of gene family expansion in T. hassleriana has taken place through the retention of polyploid duplicates, together with tandem and transpositional duplicates. We also show that the large majority (>75%) is actively expressed either globally or in specific tissues. We show that MAM and CYP83 gene families, which are crucial to GS diversification in Brassicaceae, are also recruited into specific tissue expression pathways in Cleomaceae.CONCLUSIONS:Many GS genes have expanded through polyploidy, gene transposition duplication, and tandem duplication in Cleomaceae. Duplicate retention through these mechanisms is similar to A. thaliana, but based on the expression of GS genes, Cleomaceae‐specific diversification of GS genes has taken place.
INTEGRATION OF PARTICLE-GAS SYSTEMS WITH STIFF MUTUAL DRAG INTERACTION
Authors: Yang(楊朝欽) Chao-Chin , Johansen Anders 
Published: June 2016

ABSTRACT
Numerical simulation of numerous mm/cm-sized particles embedded in a gaseous disk has become an important tool in the study of planet formation and in understanding the dust distribution in observed protoplanetary disks. However, the mutual drag force between the gas and the particles can become so stiff—particularly because of small particles and/or strong local solid concentration—that an explicit integration of this system is computationally formidable. In this work, we consider the integration of the mutual drag force in a system of Eulerian gas and Lagrangian solid particles. Despite the entanglement between the gas and the particles under the particle-mesh construct, we are able to devise a numerical algorithm that effectively decomposes the globally coupled system of equations for the mutual drag force, and makes it possible to integrate this system on a cell-by-cell basis, which considerably reduces the computational task required. We use an analytical solution for the temporal evolution of each cell to relieve the time-step constraint posed by the mutual drag force, as well as to achieve the highest degree of accuracy. To validate our algorithm, we use an extensive suite of benchmarks with known solutions in one, two, and three dimensions, including the linear growth and the nonlinear saturation of the streaming instability. We demonstrate numerical convergence and satisfactory consistency in all cases. Our algorithm can, for example, be applied to model the evolution of the streaming instability with mm/cm-sized pebbles at high mass loading, which has important consequences for the formation scenarios of planetesimals.
Travail du préconscient à l’adolescence
Authors: Assous Adèle 
Published: June 2016

Cet article est une invitation à la lecture du livre de M. Benyamin, Le travail du préconscient à l’épreuve de l’adolescence. Nous en présentons les axes majeurs de réflexion qui apportent au clinicien un éclairage très original et captivant sur le préconscient, mais aussi sur la psychosomatique et la psychanalyse de l’adolescence.
Les prescriptions sexuelles dans le Catéchisme de l’Église catholique aujourd’hui
Authors: Bazantay Christian 
Published: June 2016

Le Catéchisme de l’Église catholique affirme que le sexe n’est pas tabou. Il exprime ne pas avoir « de prévention » ni chercher à « culpabiliser les consciences » et annonce le défi de la chasteté. Et si, aujourd’hui, peu de catholiques ont lu ou savent ce que cet ouvrage contient, beaucoup d’entre eux souhaitent que la sexualité dans la vie du couple soit ré-abordée en tenant compte des évolutions de notre société. La sexualité ne représente, en volume, qu’une petite partie du CEC, mais néanmoins très explicite.
Circoncire
Authors: Cohen Solal Henri 
Published: June 2016

La circoncision est un rituel très répandu dans l’humanité, soit pour des raisons religieuses, culturelles ou hygiéniques. Elle concerne plus de 2 milliards d’hommes. Le judaïsme lui accorde une place symbolique profonde qui interpelle la bisexualité, la toute puissance, la différence des sexes, la nomination, la castration et la relation père fils. Freud qui rapporte son analyse du petit Hans en 1909, conseillait à son père Max Graf de le circoncire à sa naissance. Quel sens lui accordait-il ? « Ne le privez pas de cette énergie vitale » affirmait-il à son père. Freud associe circoncision et antisémitisme, pourquoi ?
Idéalisation et besoin de croire
Authors: Ikiz Tevfika 
Published: June 2016

La psychanalyste non seulement s’intéresse aux douleurs de ses patients, elle tente aussi de comprendre les faits sociologiques tels que décrits dans cet article. L’auteur décrit le système de croyance de la Turquie et montre comment la pensée islamique se manifeste sur les communautés religieuses. Ce terrain est difficile car les questions sur les communautés religieuses entraînent forcément des interrogations et des points de vue différents. Les problèmes concernant les communautés religieuses ont commencé en grande partie à partir du XV e siècle dans l’Empire ottoman. En partageant des désirs et des valeurs communs autour d’une même croyance, il est possible de s’éloigner des valeurs individuelles et des références. La croyance est un voyage intérieur et concerne l’expérience alors que les sectes sont considérées par les disciples comme un contenant et à la base, il y a une fusion avec le contenant. La religion unit les croyants et leur procure une sensation « océanique », ainsi l’être atteint l’infini c’est-à-dire l’immortalité. Le sentiment de plénitude et d’unité, devenir l’identique et être en fusion avec l’objet. D. Ribas définit cela comme une identification primaire où le sujet et l’objet ne peuvent se séparer l’un de l’autre avec ce sentiment de vouloir vivre ensemble dans cet univers. Dans cet article l’auteur décrit « le Nakchibendi » qui est l’une des sectes les plus répandues et qui a laissé de fortes influences sur la culture turque. Dans une structure traditionnelle, pour des personnes qui se livrent et qui s’abandonnent à un autre dont elles respectent la connaissance, ce genre de communauté explique qu’il y a encore des gens que nous protégerons de la douleur qu’entraîne l’individuation, qu’il y a encore une résistance d’individuation, de personnalisation. En suivant cette idée, on se demande comment les sociétés islamiques assimileront le modernisme car les sectes proposent de tout recommencer, de créer une nouvelle génération, un nouveau débat dépouillé de toutes négations.
Folie pubertaire et sexualité diabolique dans les débuts de la psychanalyse
Authors: Houssier Florian , Christaki Angélique 
Published: June 2016

Dans cet article, nous repartons de la période des premiers textes de Freud pour montrer comment certaines vignettes cliniques ouvrent sur l’articulation entre sexualité adolescente et symbolique religieuse en rapport avec une symptomatologie névrotique, le plus souvent sur un versant hystérique ; ces jeunes patients, peu connus ou retravaillés dans la littérature psychanalytique, montrent comment la pulsionnalité effractive de l’adolescence a des effets cliniques divers, notamment dans l’intensification du surmoi et les symptômes à caractère hallucinatoires qui en dérivent. Notre démarche, en indiquant comment Freud tente de dédiaboliser la sexualité hystérique concernant nombre de jeunes gens, ouvre un débat autour des débuts de la psychanalyse. Cela nous amène à poser l’hypothèse selon laquelle certains troubles de l’adolescence, en passant par les traductions dans le champ symbolique du religieux, ont constitué un facteur décisif dans la découverte de la psychanalyse.
Évaluer les services rendus par les dépendances vertes des infrastructures linéaires de transport : une démarche exploratoire
Authors: Labarraque Dorothée 
Published: June 2016

Les dépendances vertes des infrastructures linéaires de transport, par les processus écologiques qui s’y exercent, peuvent rendre des services à la société humaine. Quels sont-ils ? Peut-on, et y a-t-il un intérêt à faire varier, en nombre et/ou en quantité, ces services ? L’article, sur la base d’un cas concret, propose une évaluation préliminaire des services produits par les habitats naturels des dépendances de l’infrastructure. Pour une infrastructure de transport routier et ferroviaire, seuls les services dits de régulation sont susceptibles d’être présents. L’étude montre qu’il existe bien une variabilité spatiale de ces services au sein des dépendances vertes. Celle-ci est fortement dépendante de l’occupation du sol et dans une moindre mesure, de l’environnement adjacent. L’article met cependant en exergue le besoin de recherche pour évaluer quantitativement les services produits à une échelle locale. L’article explore ensuite les facteurs qui pourraient faire varier la production des services. Ils peuvent être de l’ordre des pratiques de gestion et d’entretien, mais aussi de l’aménagement paysager. Il en ressort que de nouvelles compétences pourraient être développées pour une conception paysagère des services écosystémiques. L’approche anthropocentrique des services écosystémiques permet également d’envisager que les maîtres d’ouvrage puissent s’appuyer sur des actions favorisant certains services pour une écoconception de leur infrastructure, une meilleure acceptabilité du projet voire une optimisation économique de leur aménagement.
Effect of cantilever length on stress distribution around implants in mandibular overdentures supported by two and three implants
Authors: Ebadian Behnaz , Mosharraf Ramin , Khodaeian Niloufar 
Published: June 2016

ABSTRACT
Objective: There is no definitive study comparing stress distribution around two versus three implants in implant-retained overdentures with different cantilever length. The purpose of this finite element study was to evaluate stress pattern around the implants of the 2 or 3 implant-supported mandibular overdenture with different cantilevered length. Materials and Methods: The models used in this study were 2 and 3 implant-supported overdenture with bar and clip attachment system on an edentulous mandibular arch. Each model was modified according to cantilever length (0 mm, 7 mm, and 13 mm); thus, 6 models were obtained. The vertical load of 15 and 30 pounds were applied unilaterally to the first molar and 15 pounds to the first premolar, and the stress in bone was analyzed. Results: With increasing cantilever length, no similar stress pattern changes were observed in different areas, but in most instances, an increase in cantilever length did not increase the stress around the implant adjacent to cantilever. Conclusions: Within the limitations of this study, it can be concluded that increasing of cantilever length in mandibular overdentures retained by 2–3 implants did not cause distinct increasing in stress, especially around the implant adjacent to cantilever, it may be helpful to use cantilever in cases of mandibular overdenture supported by splinted implants with insufficient retention and stability. Based on the findings of this study, optimal cantilever length in mandibular overdenture cannot be determined.
The maxillary molar endodontic access opening: A microscope-based approach
Authors: Mamoun John Sami 
Published: June 2016

ABSTRACTThis article reviews the basic clinical techniques of performing a maxillary molar endodontic access opening, starting from the initial access opening into the pulp chamber, to the point where a size #10 file has been advanced to the apices of all three or four (or more) canals. The article explains how the use of the dental surgical operating microscope or microscope-level loupes magnification of ×6–8 or greater, combined with head-mounted or coaxial illumination, improve the ability of a dentist to identify microscopic root canal orifices, which facilitates the efficient creation of conservative access openings with adequate straight-line access in maxillary molars. Magnified photos illustrate various microscopic anatomical structures or landmarks of the initial access opening. Techniques are explored for implementing an access opening for teeth with vital versus necrotic pulpal tissues. The article also explores the use of piezoelectric or ultrasonic instruments for revealing root canal orifices and for removing pulp stones or calcified pulpal tissue inside the pulp chamber.
Comparative in vitro study of the effectiveness of Green tea extract and common storage media on periodontal ligament fibroblast viability
Authors: Adeli Fahimeh , Zabihi Ebrahim , Abedian Zeinab , Gharekhani Samane , Pouramir Mahdi , Khafri Soraya , Ghasempour Maryam 
Published: June 2016

ABSTRACT
Objective: Green tea extract (GTE) was shown to be effective in preserving periodontal ligament fibroblasts (PDLFs) of avulsed teeth. This study aimed at determining the potential of GTE in preserving the viability of PDLFs comparing with different storage media. Materials and Methods: Periodontal ligament cells were obtained from freshly extracted healthy impacted third molars and cultured in Dulbecco's Modified Eagle Medium (DMEM). Cell viability was determined by storing the cells in seven media; DMEM, tap water, Hank's balanced salt solution (HBSS), whole milk, hypotonic sucrose solution, GTE, and GTE + sucrose for 1, 2, 4, and 24 h at 37°C using tetrazolium salt-based colorimetric (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay. Statistical analysis was performed by one-way analysis of variance and post hoc tests. Results: GTE showed significantly higher protective effect than HBSS at 2, 4, and 24 h (P = 0.009, P = 0.02, P = 0.016), DMED at 2 h (P = 0.003), and milk at 4 h (P = 0.039). Conclusion: Although with undesirable osmolality and pH, GTE had a good ability in preserving the PDLFs comparing with other studied media.
Clinical Decision Support for a Multicenter Trial of Pediatric Head Trauma
Authors: Swietlik Marguerite , Deakyne Sara , Hoffman Jeffrey , Grundmeier Robert , Paterno Marilyn , Rocha Beatriz , Schaeffer Molly , Pabbathi Deepika , Alessandrini Evaline , Ballard Dustin , Goldberg Howard , Kuppermann Nathan , Dayan Peter , Tham Eric ,   for the Pediatric Emergency Care Applied Research Network (PECARN)
Published: June 2016

SummaryFor children who present to emergency departments (EDs) due to blunt head trauma, ED clinicians must decide who requires computed tomography (CT) scanning to evaluate for traumatic brain injury (TBI). The Pediatric Emergency Care Applied Research Network (PECARN) derived and validated two age-based prediction rules to identify children at very low risk of clinically-important traumatic brain injuries (ciTBIs) who do not typically require CT scans. In this case report, we describe the strategy used to implement the PECARN TBI prediction rules via electronic health record (EHR) clinical decision support (CDS) as the intervention in a multicenter clinical trial.Thirteen EDs participated in this trial. The 10 sites receiving the CDS intervention used the Epic® EHR. All sites implementing EHR-based CDS built the rules by using the vendor’s CDS engine. Based on a sociotechnical analysis, we designed the CDS so that recommendations could be displayed immediately after any provider entered prediction rule data. One central site developed and tested the intervention package to be exported to other sites. The intervention package included a clinical trial alert, an electronic data collection form, the CDS rules and the format for recommendations.The original PECARN head trauma prediction rules were derived from physician documentation while this pragmatic trial led each site to customize their workflows and allow multiple different providers to complete the head trauma assessments. These differences in workflows led to varying completion rates across sites as well as differences in the types of providers completing the electronic data form. Site variation in internal change management processes made it challenging to maintain the same rigor across all sites. This led to downstream effects when data reports were developed.The process of a centralized build and export of a CDS system in one commercial EHR system successfully supported a multicenter clinical trial.