bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSCI President’s Message
Authors: Winston Brent W 
Published: May 2017

Dear Clinical and Investigative Medicine (CIM) readers,

I write this message to solicit your help in making the Canadian Society for Clinical Investigation a vital society for medicine in Canada and to inform CIM readers about the CSCI. The CSCI plays an important role in maintaining the sustainability of our health care system. The only way to improve health care for Canadians is to continually optimize our methods of treatment and to gain a better understanding of the illnesses that face our population. Systematic research in all facets of healthcare, be it the molecular mechanisms of disease, the efficacy of treatment alternatives or the functioning of the health care system is the only way to guarantee a better system for the next generation of Canadians.

As the only Society in Canada with a dedicated focus on the profession of clinician-researchers and our young clinician-investigator trainees, we provide crucial support for the enterprise of clinical investigation in Canada.

The CSCI’s mandate is to promote clinical and basic research in the field of human health throughout Canada, to lobby for adequate research funding at the federal, regional and local levels, and to support Canadian researchers in their endeavours and at all stages of their careers.

The CSCI organizes an annual meeting that highlights research work by its members and guest lecturers that speak with authority on issues that face Clinician-Investigators in Canada. CSCI is currently in the midst of a reorganization that started several years ago and has resulted in the establishment of an independent meeting, a renewed Young Investigators Forum and establishing close ties with the Clinician Investigator Trainee Association of Canada (CITAC). Reinforcing our efforts to revitalize our organization, we recently hired a new organization, Gallaher Membership Services and together we are streamlining our Society’s operations. The new CSCI website address is www.csci-scrc.ca. The website contains vital information about the CSCI, CIM and information about becoming a member of the CSCI.

Our Society’s journal, Clinical and Investigative Medicine (CIM), has also undergone a transformation and is under the leadership of Dr. Jonathan Angel of Ottawa. We are proud of the changes that have occurred at CIM and look forward to the continued success of this journal.

I sincerely hope that all Clinician-Investigators in Canada, irrespective of their stage of training or career, will adopt the changes that have been made and those that will continue to be made at CSCI by joining CSCI and participating in strengthening the voice for Clinical-Investigation in Canada. Joining CSCI allows members to publish in CIM at no charge. This is a tremendous value for our members. Communication with CSCI members will continue through CIM where we will give updates announcing further developments at the CSCI. I welcome any feedback or suggestions and hope that you enjoy reading CIM as much as I do.

Sincerely,

Brent W. Winston, MD, FRCPC, FACP, FCCM
President, CSCI
Re: Clin Invest Med. 2006 Jun;29(3):154-8
Authors: CIM _ 
Published: May 2017

Clinical and Investigative Medicine wishes to inform its readers of the following incident of redundant publication. The publication: de Lorgeril M, Salen P The Mediterranean diet in secondary prevention of coronary heart disease. Clin Invest Med. 2006 Jun;29(3):154-8 contains a substantial amount of information and text reported in the previously published article, de Lorgeril M, Salen P. The Mediterranean-style diet for the prevention of cardiovascular diseases. Public Health Nutr. 2006 Feb;9(1A):118-23.
Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment
Authors: Şahin Füsun , Yildiz Pinar 
Published: May 2017

Purpose: CA-125 is a high molecular weight mucin-like glycoprotein and an ovarian cancer antigen. Elevated CA-125 levels are also seen with various other benign and malignant conditions. In this study, the ability of CA-125 to predict pulmonary tuberculosis activity was investigated.

Methods: This analytical study included 42 cases with active tuberculosis (Group 1), 35 cases with inactive tuberculosis (Group 2) and 20 healthy subjects (Group 3). CA-125 measurements were taken in all three groups. Measurements in Group 1 were repeated after completing a two month anti-tuberculosis treatment in 38 of the 42 patients.

Results: Mean serum CA-125 level for Group 1 was 76.48±24.71 U/mL, which was significantly higher than levels in Group 2 (20.01±7.89 U/mL) and Group 3 (18.32±2.87 U/mL) (p < 0.001). Of the 38 patients in Group 1 who were studied both pre- and post-treatment, CA-125 levels decreased significantly: from 78.88±24.72 U/mL before treatment to 22.78±8.02 U/mL after treatment (p < 0.001). There was no statistically significant difference between the post-treatment values of Group 1 and either Group 2 and Group 3 values (p > 0.05). Group 2 and Group 3 levels were not significantly different (p > 0.05). The cut-off level for accurate determination of activity was 36.35 U/mL. The sensitivity at this level was 97.6% and specificity was 100%.

Conclusion: Our findings suggest that CA-125 can be a beneficial parameter in determination of pulmonary tuberculosis activity and the evaluation of response to treatment.
Proceedings from the 5th Annual University of Calgary Leaders in Medicine Research Symposium
Authors: Thornton Christina S , Keough Michael B , Roberts Jodie I , Yipp Bryan , Hollenberg Morley , Bau Jason T , Peplowski Michael A , Beck Paul L 
Published: May 2017

On November 8, 2013, the Leaders in Medicine (LIM) program hosted the 5th Annual Research Symposium. Dr. Jerrold Ellner, Chief of the Infectious Diseases section at Boston Medical Centre and Professor of Medicine at Boston University School of Medicine, was the keynote speaker and presented his lecture entitled “Tuberculosis – Past, Present and Future”. The LIM symposium gives a forum for LIM as well as non-LIM medical students to present their research work as either an oral or poster presentation. There were a total of 53 abstracts presented and five oral presentations. The symposium was attended by over 100 students and more than 30 staff members.

The oral presentations included
• Amrita Roy, Aboriginal identity, ethnic minority status, and prenatal depressive symptoms in a longitudinal pregnancy cohort study in Alberta.
• David Nicholl, Obstructive sleep apnea treatment with continuous positive airway pressure decreases intraglomerular pressure and alters renal sensitivity to angiotensin.
• James Cotton, An assemblage A Giardia cathepsin B protease degrades interleukin-8 and attenuates neutrophil chemotaxis.
• Krystyna Ediger, Alexander Arnold and Emily Shelton, Rebuilding the Calgary Student Run Clinic: A Model for Sustainability.
• Sarah MacEachern, Inhibiting inducible nitric oxide synthase restores electrogenic ion transport in experimental IBD: a novel role for enteric glia.

See the article on the University of Calgary Leaders in Medicine Program, “A Prescription that Addresses the Decline of Basic Science Education in Medical School” in this same issue of CIM for more details on the program. In short, the LIM Research Symposium has the following objectives: (1) to showcase the impressive variety of projects undertaken by students in the LIM Program as well as U of C medical students; (2) to encourage medical student participation in research and special projects; and, (3) to inform students and faculty about the diversity of opportunities available for research and special projects during medical school and beyond.

The following abstracts are those that were put forward for publication.
Scientific overview: CSCI-CITAC Annual General Meeting and Young Investigators’ Forum 2014
Authors: Keow Jonathan , Zhao Eric , Samuel Nardin , Dey Ayan , Schneider Raphael , Chen Michael , Wang Xin 
Published: May 2017

The Canadian Society of Clinician Investigators (CSCI) and Clinical Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada (CITAC/ACCFC) annual general meeting (AGM) was held in Toronto during November 21-24, 2015 for the first time in conjunction with the University of Toronto Clinician-Investigator Program Research Day.
The overall theme for this year’s meeting was the role of mentorship in career development, with presentations from Dr. Chaim Bell (University of Toronto), Dr. Shurjeel Choudhri (Bayer Healthcare), Dr. Ken Croitoru (University of Toronto), Dr. Astrid Guttman (University of Toronto), Dr. Prabhat Jha (University of Toronto) and Dr. Sheila Singh (McMaster University).
The keynote speakers of the 2014 AGM included Dr. Qutayba Hamid, who was presented with the Distinguished Scientist Award, Dr. Ravi Retnakaran, who was presented with the Joe Doupe Award, and Dr. Lorne Babiuk, who was the CSCI-RCPSC Henry Friesen Award winner.
The highlight of the conference was, once again, the outstanding scientific presentations from the numerous clinician investigator (CI) trainees from across the country who presented at the Young Investigators’ Forum. Their research topics spanned the diverse fields of science and medicine, ranging from basic science to cutting-edge translational research, and their work has been summarized in this review.
Over 120 abstracts were presented at this year’s meeting. This work was presented during two poster sessions, with the six most outstanding submitted abstracts presented in the form of oral presentations during the President’s Forum.
Is resveratrol therapeutic when used to treat allergic rhinitis in rats?
Authors: Bozdemir Kazım , Şahin Ethem , Altintoprak Niyazi , Muluk Nuray B , Cengiz Betül P , Acar Mustafa , Cingi Cemal 
Published: May 2017

Purpose: Resveratrol has anti-infective, anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effect of resveratrol in a rat experimental model of allergic rhinitis (AR).

Methods: Wistar albino rats were divided into three groups: control (n=7), AR with no treatment (AR+NoTr, n=7) and AR with resveratrol treatment (AR+Res, n=7). For AR+Res, AR was induced and resveratrol given on days 21-28. On day 28, the total blood IgE levels were measured. Allergic symptoms (sneezing, nose-rubbing, eye lacrimation and nasal congestion) were scored on a 0-3 point scale, and histopathological changes in the nasal mucosa were evaluated.

Results: Allergic symptom score of AR+NoTr was higher than the other two groups and the score of AR+Res was higher than the control group. Histopathologically, neither ciliary loss nor chondrocyte hypertrophy differed among the three groups; however, vascular congestion, inflammatory and plasma cell numbers, eosinophil and mast cell infiltration and goblet cell numbers were higher and mast cell infiltration was more prominent in AR+NoTr than in AR+Res and control. AR+Res and control did not differ significantly in any histological parameter.
In AR+NoTr, nasal mucosa exhibited ciliary loss, squamous epithelial metaplasia, inflammatory cell infiltration, vascular congestion of the lamina propria and goblet cell epithelial metaplasia. In AR+Res, goblet cell metaplasia was focal or absent and infiltration of the lamina propria by inflammatory cells, eosinophils, and plasma cells was reduced relative to AR+NoTr.

Conclusion: Allergic symptoms and tissue reactions were reduced by resveratrol treatment in rats with experimentally-induced AR.
Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease
Authors: Akkus Mehmet N , Ormam Adil , Seyis Sabri , Baran Çagdas , Görür Aysegül , Bilen Mehmet N 
Published: May 2017

Purpose: The purpose of this study was to determine whether the plasma levels of soluble extracellular matrix metalloproteinase inducer (EMMPRIN) differed among the patients with ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and stable coronary artery disease (CAD) and the healthy controls, and to identify the factors associated with the differences in plasma levels of this this protein among patients in these groups.

Methods: Plasma EMMPRIN levels were compared among four age- and sex-matched groups of patients with STEMI, NSTEMI and stable CAD and healthy controls (n=44 per group), then logistic regression and correlation analyses were conducted for the whole acute myocardial infarction (AMI) patients group.

Results: EMMPRIN levels were significantly higher in the STEMI (39.4±9.2ng/mL) and NSTEMI (37.1±10.5ng/mL) groups than in either the stable CAD (27.5±4.7ng/mL) or control (24.5±5.8ng/mL) groups (p
Comparison of neck ultrasonography with a pH meter to confirm correct position of nasogastric tube
Authors: Muslu Bunyamin , Demircioglu Rüveyda I , Gözdemir Muhammet , Usta Burhanettin 
Published: May 2017

Purpose: The aim of this study was to compare pH meter and neck ultrasonograph for evaluation of nasogastric tube (NGT) position.

Methods: A total of 35 adult patients who required NGT insertion were included. The NGT was inserted by an anesthetist after endotracheal intubation, and the transducer was placed transversely on the neck, just superior to the suprasternal notch. The passage of the NGT in the esophagus was evaluated by a sonographer, and the stomach was emptied by nasogastric suction. Secretion from inside the NGT was analyzed using a pH meter. The tip of the NGT was accepted as being in the stomach if the pH measured between 1 and 5. Neck ultrasonography was compared with the pH meter analysis for confirmation of NGT position.

Results: Ultrasonography was highly sensitive (100% (95% CI 89.6–100%) and specific (97.2% (95% CI 85.4–99.5%) for evaluation of NGT position. The specificity for the pH meter was 100% (95% CI 16.6–100%), while the sensitivity was 76.5% (95% CI 58.8–89.2%).

Conclusions: This study showed that neck ultrasonography is more sensitive than the pH meter for confirmation of NGT position.
Perilaku Anak Jalanan dan Strategi Pengentasannya di Bandung, Bogor, dan Jakarta
Authors: Tjahjorini Sri , Sumardjo Sumardjo , Slamet Margono , Susanto Djoko , Gani Darwis S 
Published: May 2017

<p><em>Street child problems, like iceberge phenomenon, of which the regional pockets, the distribution and the age tremendously increase day by day. Since 1997 the government of Indonesia through the Social Ministry has been carrying out efforts to overcome the problems, but up to now the efforts have not yielded the expected results because of the limited information of the problems. The present research was addressed to provide informations on the phenomenon profiles of street children and strategies for their elimination in Bandung, Bogor and Jakarta. Data were collected using structured interviews, focus group discussion and direct observation. The collected data were analysed using parametric and non-parametric statistics. Population were street children, 5-21 years of age. Sample in each region was consisted of 75 persons, 50 males and 25 famales, drawn using cluster random sampling technique, and 25 parents of the respondens as a cross check. The influence of family background on the street children behavior, direct or indirectly, was more obvious compared to that of environmental background. The latter was indirect through sociologic characteristics of the street children particularly on the non formal education. Strategy for elimination of the street children could be equally applied for the whole regions, except for its approach, which can use the TRIBINA, which means Human Building, Environmental Building and Efforts Building could be employed.</em></p><p> </p>
Aktualisasi Tanggungjawab Sosial Masyarakat pada Kelu arga Miskin d i Perdesaan: Studi Kasus Desa Pedalaman di Kabupaten Bone
Authors: Bustang Bustang , Sugihen Basita G , Slamet Margono , Susanto Djoko 
Published: May 2017

<p><em>This research was intended to formulate the strategy to increase The Actuality and Social Responsibility to Poor Families at Rural Area. Survey were implemented among 57 selected samples, started Nopember 2006 until April 2007. Data was analyzed by using both correlation and path analysis. The results indicated that a number of respondent had a high social responsibility. The increasement of social responsibility and level of empowerment were influenced by implementation of good government of local organization, income, and formal education. This study suggests an alternative model of empowerment in order to social responsibility.</em></p><p> </p><p><em><br /></em><em></em></p>
Kinerja Penyuluhan di Nusa Tenggara Timur
Authors: Marius Jelamu Ardu , Sumardjo Sumardjo , Slamet Margono , Asngari Pang S 
Published: May 2017

<p><em>The objectives of this research were to portray the influence of internal and external factors to the performance of the agricultural extension. The individual characrterization of the agricultural extension agents were the internal factors which assumed to influence toward the performance of agricultural extension and those other i.e the non formal extension education (diklat), the milieu, and the extension organization structure were the external factors. The respondents were selected by the random and purposive sampling method in the three regency as research area. Data analysis was done by using descriptive and Linear Structural Relationship (LISREL) program 8.72 by Structural Equation Modelling (SEM) models. The results of the research showed that the non formal extension education and the extension organization structure were influenced positively and significantly to the performacen of extension (external factors), but those other were not. </em></p><em><br /></em>
Metropolis and Hermeneutics: an Interview with Gianni Vattimo by Georges Teyssot
Authors: Tinning Søren 
Published: May 2017

This interview was originally published in the catalogue of the XVII Milan Triennial as: “Metropoli ed ermeneutica: un’intervista,” in: Le cittá del mondo e il futuro delle metropolis. Oltre la cittá, la metropolis, cur. Georges Teyssot (Milano: Electa, 1988), 268–272. English translation is published here with the permission of Gianni Vattimo.

Article received: December 12, 2016; Article accepted: January 10, 2017; Published online: April 20, 2017
Interview

How to cite this article: "Metropolis and Hermeneutics: an Interview with Gianni Vattimo." AM Journal of Art and Media Studies12 (2017): 1-8. doi: 10.25038/am.v0i12.162
Modeling of wear behavior of Al/B4C composites produced by powder metallurgy
Authors: Şahin İsmail , Bektaş Aslı , Gül Ferhat , Çinici Hanifi 
Published: May 2017

Abstract
Wear characteristics of composites, Al matrix reinforced with B4C particles percentages of 5, 10,15 and 20 produced by the powder metallurgy method were studied in this study. For this purpose, a mixture of Al and B4C powders were pressed under 650 MPa pressure and then sintered at 635 °C. The analysis of hardness, density and microstructure was performed. The produced samples were worn using a pin-on-disk abrasion device under 10, 20 and 30 N load through 500, 800 and 1200 mesh SiC abrasive papers. The obtained wear values were implemented in an artificial neural network (ANN) model having three inputs and one output using feed forward backpropagation Levenberg-Marquardt algorithm. Thus, the optimum wear conditions and hardness values were determined.
Dry friction behavior of NiCrBSi-%35W2C coated brake disks
Authors: Güney Bekir , Mutlu İbrahim 
Published: May 2017

Abstract
For speeding up motor vehicles, new brake disk materials with higher frictional need to be developed. Brake disks work under very difficult thermomechanical conditions due to high temperature and wear. As most of commercial disks have high wear rate and low braking performance, there is a need for development and manufacturing of new disks-brake linings to reduce wear and to increase braking performance in motor vehicles. Ceramic coated disks have shown good stability in friction coefficient at a high speed and high energy braking conditions. Therefore, flame spraying technique for cermet coating materials has been chosen as a good method to produce coatings on a metallic substrate. In this study, a sample cast iron disk with ventilation channels coated with NiCrBSi-%35W2C powder by the flame spraying method were investigated. The braking performances of uncoated disk and coated disk were tested according to SAE J2430 test standard. It was found out that the coated disk had lower surface roughness and higher coefficient of friction than the uncoated disk. The NiCrBSi-%35W2C coated disk exhibited less wear, a higher coefficient of friction and longer life than the uncoated disk. As a result, the NiCrBSi-%35W2C coated disk could be a much better alternative for a new generation of brake disks in the motor vehicles than the uncoated disk.
Evaluation of robot-guided minimally invasive implantation of 2067 pedicle screws
Authors: Keric Naureen , Doenitz Christian , Haj Amer , Rachwal-Czyzewicz Izabela , Renovanz Mirjam , Wesp Dominik M. A. , Boor Stephan , Conrad Jens , Brawanski Alexander , Giese Alf , Kantelhardt Sven R. 
Published: May 2017

ObjectiveRecent studies have investigated the role of spinal image guidance for pedicle screw placement. Many authors have observed an elevated placement accuracy and overall improvement of outcome measures. This study assessed a bi-institutional experience following introduction of the Renaissance miniature robot for spinal image guidance in Europe.MethodsThe medical records and radiographs of all patients who underwent robot-guided implantation of spinal instrumentation using the novel system (between October 2011 and March 2015 in Mainz and February 2014 and February 2016 in Regensburg) were reviewed to determine the efficacy and safety of the newly introduced robotic system. Screw position accuracy, complications, exposure durations to intraoperative radiation, and reoperation rate were assessed.ResultsOf the 413 surgeries that used robotic guidance, 406 were via a minimally invasive approach. In 7 cases the surgeon switched to conventional screw placement, using a midline approach, due to referencing problems. A total of 2067 screws were implanted using robotic guidance, and 1857 screws were evaluated by postoperative CT. Of the 1857 screws, 1799 (96.9%) were classified as having an acceptable or good position, whereas 38 screws (2%) showed deviations of 3–6 mm and 20 screws (1.1%) had deviations > 6 mm. Nine misplaced screws, implanted in 7 patients, required revision surgery, yielding a screw revision rate of 0.48% of the screws and 7 of 406 (1.7%) of the patients. The mean ± SD per-patient intraoperative fluoroscopy exposure was 114.4 (± 72.5) seconds for 5.1 screws on average and any further procedure required. Perioperative and direct postoperative complications included hemorrhage (2 patients, 0.49%) and wound infections necessitating surgical revision (20 patients, 4.9%).ConclusionsThe hexapod miniature robotic device proved to be a safe and robust instrument in all situations, including those in which patients were treated on an emergency basis. Placement accuracy was high; peri- and early postoperative complication rates were found to be lower than rates published in other series of percutaneous screw placement techniques. Intraoperative radiation exposure was found to be comparable to published values for other minimally invasive and conventional approaches.