bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Education Level Mitigate the Effect of Poverty on Total Knee Arthroplasty Outcomes?
Authors: Goodman Susan M. , Mandl Lisa A. , Mehta Bella , Navarro‐Millan Iris , Russell Linda A. , Parks Michael L. , Dey Shirin A. , Crego Daisy , Figgie Mark P. , Nguyen Joseph T. , Szymonifka Jackie , Zhang Meng , Bass Anne R. 
Published: November 2017

ObjectiveTotal knee arthroplasty (TKA) outcomes are worse for patients from poor neighborhoods, but whether education mitigates the effect of poverty is not known. We assessed the interaction between education and poverty on 2‐year Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function.MethodsPatient‐level variables from an institutional registry were linked to US Census Bureau data (census tract [CT] level). Statistical models including patient and CT‐level variables were constructed within multilevel frameworks. Linear mixed‐effects models with separate random intercepts for each CT were used to assess the interaction between education and poverty at the individual and community level on WOMAC scores.ResultsOf 3,970 TKA patients, 2,438 (61%) had some college or more. Having no college was associated with worse pain and function at baseline and 2 years (P = 0.0001). Living in a poor neighborhood (>20% below poverty line) was associated with worse 2‐year pain (P = 0.02) and function (P = 0.006). There was a strong interaction between individual education and community poverty with WOMAC scores at 2 years. Patients without college living in poor communities had pain scores that were ~10 points worse than those with some college (83.4% versus 75.7%; P < 0.0001); in wealthy communities, college was associated with a 1‐point difference in pain. Function was similar.ConclusionIn poor communities, those without college attain 2‐year WOMAC scores that are 10 points worse than those with some college; education has no impact on TKA outcomes in wealthy communities. How education protects those in impoverished communities warrants further study.
Single Crystal Microwires of p‐DTS(FBTTh2)2 and Their Use in the Fabrication of Field‐Effect Transistors and Photodetectors
Authors: Cui Qiuhong , Hu Yuanyuan , Zhou Cheng , Teng Feng , Huang Jianfei , Zhugayevych Andriy , Tretiak Sergei , Nguyen Thuc‐Quyen , Bazan Guillermo C. 
Published: November 2017

AbstractSingle crystal microwires of a well‐studied organic semiconductor used in organic solar cells, namely p‐DTS(FBTTh2)2, are prepared via a self‐assembly method in solution. The high level of intermolecular organization in the single crystals facilitates migration of charges, relative to solution‐processed films, and provides insight into the intrinsic charge transport properties of p‐DTS(FBTTh2)2. Field‐effect transistors based on the microwires can achieve hole mobilities on the order of ≈1.8 cm2 V−1 s−1. Furthermore, these microwires show photoresponsive electrical characteristics and can act as photoswitches, with switch ratios over 1000. These experimental results are interpreted using theoretical simulations using an atomistic density functional theory approach. Based on the lattice organization, intermolecular couplings and reorganization energies are calculated, and hole mobilities for comparison with experimental measurements are further estimated. These results demonstrate a unique example of the optoelectronic applications of p‐DTS(FBTTh2)2 microwires.
Combination of Hybrid CVD and Cation Exchange for Upscaling Cs‐Substituted Mixed Cation Perovskite Solar Cells with High Efficiency and Stability
Authors: Jiang Yan , Leyden Matthew R. , Qiu Longbin , Wang Shenghao , Ono Luis K. , Wu Zhifang , Juarez‐Perez Emilio J. , Qi Yabing 
Published: November 2017

AbstractMixed cation hybrid perovskites such as CsxFA1−xPbI3 are promising materials for solar cell applications, due to their excellent photoelectronic properties and improved stability. Although power conversion efficiencies (PCEs) as high as 18.16% have been reported, devices are mostly processed by the anti‐solvent method, which is difficult for further scaling‐up. Here, a method to fabricate CsxFA1−xPbI3 by performing Cs cation exchange on hybrid chemical vapor deposition grown FAPbI3 with the Cs+ ratio adjustable from 0 to 24% is reported. The champion perovskite module based on Cs0.07FA0.93PbI3 with an active area of 12.0 cm2 shows a module PCE of 14.6% and PCE loss/area of 0.17% cm−2, demonstrating the significant advantage of this method toward scaling‐up. This in‐depth study shows that when the perovskite films prepared by this method contain 6.6% Cs+ in bulk and 15.0% at the surface, that is, Cs0.07FA0.93PbI3, solar cell devices show not only significantly increased PCEs but also substantially improved stability, due to favorable energy level alignment with TiO2 electron transport layer and spiro‐MeOTAD hole transport layer, increased grain size, and improved perovskite phase stability.
Intermolecular Rhodium(II)‐Catalyzed Allylic C(sp3)–H Amination of Cyclic Enamides
Authors: Rey‐Rodriguez Romain , Jestin Grégory , Gandon Vincent , Grelier Gwendal , Retailleau Pascal , Darses Benjamin , Dauban Philippe , Gillaizeau Isabelle 
Published: November 2017

AbstractThe intermolecular rhodium(II)‐catalyzed C(sp3)–H amination of enamides gives access to new 4‐aminopiperidine derivatives that are useful building blocks in medicinal chemistry. This efficient transformation proceeds at room temperature with complete regio‐ and chemoselectivity in favor of the allylic C(sp3)–H bond, and has a broad functional group tolerance. In addition, the matched combination of the chiral complex Rh2(S‐nta)4 [nta=(S)‐N‐1,8‐naphthoylalanine] with an optically pure (S)‐sulfonimidamide allows the isolation of allylic amines with excellent stereocontrol.magnified image
Battery‐Free, Human‐Motion‐Powered Light‐Emitting Fabric: Mechanoluminescent Textile
Authors: Jeong Soon Moon , Song Seongkyu , Seo Hye‐Jin , Choi Won Mi , Hwang Sung‐Ho , Lee Se Geun , Lim Sang Kyoo 
Published: November 2017

AbstractMuch effort is being directed at developing wearable devices because they offer the potential combination of real‐time personal communication and convenient portability. In this sense, communicative textiles that can sense and respond to changes in their environment, that is, smart textiles, are attracting attention because they are easy to integrate into the human body. In particular, light‐emitting textiles are preferred for high‐visibility outfits for personal safety and attractive signaling that enable mutual recognition or new forms of communication. However, most light‐emitting textiles, including weavable optical fibers and fiber‐shaped electroluminescent devices, require electric power supply. This paper presents a mechanoluminescent fiber that is capable of emitting light and can potentially be powered just by human motions, such as body movement and muscle stretching, instead of a battery. This is achieved by utilizing a robust mechanoluminescent (ML) fiber developed by improving the binding of mechanoluminescent ZnS‐embedded‐polydimethylsiloxane with a primer‐treated cross‐shaped fiber frame and employing an adhesive layer. A novel ML fabric, created by weaving ML fibers, is also presented, which is applicable to wearable light‐emitting fabrics. Battery‐free, human motion‐powered ML fiber is expected to make environmentally friendly and sustainable light, and further paves the way for new wearable devices that reduce energy waste.
Dual Modulated Lateral Photoresistance Effect Observed on Silicon‐Based Discontinuous Copper Film
Authors: Gan Zhikai , Zhou Peiqi , Huang Xu , Mei Chunlian , Wang Hui 
Published: November 2017

AbstractA dual modulated lateral photoresistance effect is observed on silicon‐based discontinuous copper film. Through the spatial movement of a laser beam spot, the lateral resistance of the structure can be modulated linearly with polarity under different testing mode. Through applying an electric pulse, the lateral resistance versus laser position curve can be entirely shifted. Carrier diffusion and drift model and charge trap model are set up to explain the dual modulated lateral photoresistance effect. This work adds functionality to Cu materials and is useful for the development of laser‐ and pulse‐modulated photoelectric resistors, switches, and sensors.
Design and Performance of Rechargeable Sodium Ion Batteries, and Symmetrical Li‐Ion Batteries with Supercapacitor‐Like Power Density Based upon Polyoxovanadates
Authors: Chen Jia‐Jia , Ye Jian‐Chuan , Zhang Xia‐Guang , Symes Mark D. , Fan Shao‐Cong , Long De‐Liang , Zheng Ming‐Sen , Wu De‐Yin , Cronin Leroy , Dong Quan‐Feng 
Published: November 2017

AbstractThe polyanion Li7V15O36(CO3) is a nanosized molecular cluster (≈1 nm in size), that has the potential to form an open host framework with a higher surface‐to‐bulk ratio than conventional transition metal oxide electrode materials. Herein, practical rechargeable Na‐ion batteries and symmetric Li‐ion batteries are demonstrated based on the polyoxovanadate Li7V15O36(CO3). The vanadium centers in {V15O36(CO3)} do not all have the same VIV/V redox potentials, which permits symmetric devices to be created from this material that exhibit battery‐like energy density and supercapacitor‐like power density. An ultrahigh specific power of 51.5 kW kg−1 at 100 A g−1 and a specific energy of 125 W h kg−1 can be achieved, along with a long cycling life (>500 cycles). Moreover, electrochemical and theoretical studies reveal that {V15O36(CO3)} also allows the transport of large cations, like Na+, and that it can serve as the cathode material for rechargeable Na‐ion batteries with a high specific capacity of 240 mA h g−1 and a specific energy of 390 W h kg−1 for the full Na‐ion battery. Finally, the polyoxometalate material from these electrochemical energy storage devices can be easily extracted from spent electrodes by simple treatment with water, providing a potential route to recycling of the redox active material.
Ruxolitinib‐associated infections: A systematic review and meta‐analysis
Authors: Lussana Federico , Cattaneo Marco , Rambaldi Alessandro , Squizzato Alessandro 
Published: November 2017

AbstractRuxolitinib exerts immunosuppressive activity that may increase the risk of infectious complications. We performed a systematic review of the literature with the aim of estimating the risk of infections in patients treated with ruxolitinib. Studies were identified by electronic search of MEDLINE and EMBASE database. Differences in the incidence of infectious events between ruxolitinib and comparison groups were expressed as odds ratios (ORs) and 95% confidence intervals (95% CI). Five phase III randomized clinical trials (RCTs) (3 phase IIIa with their extended phase and 2 phase IIIb), 6 phase IV studies and 28 case reports were included in this systematic review. Ruxolitinib was associated with a statistically significant increased risk of herpes zoster infection compared to control group in 3 RCTs including patients with polycythemia vera (OR 7.39 [1.33, 41.07]) and in a pooled analysis of the extended phase IIIa RCTs (OR 5.20 [95%CI 1.27, 21.18]). In the larger phase IV post‐marketing study, the incidence of the most frequent infections was 8% for herpes zoster, 6.1% for bronchitis and 6% for urinary tract infections. In the published case reports, the most frequent infections were tuberculosis (N = 10), hepatitis B reactivation (N = 5) and pneumocystis jeroveci infection (N = 2). Evidence is not solid enough to accurately estimate the risk of infection in ruxolitinib‐treated patients. However, published data clearly suggest that the infection risk may be clinically relevant. Well‐designed studies are warranted to evaluate the risk of ruxolitinib‐associated infection, in order to identify the most appropriate antimicrobial prophylactic strategy.
Driver mutations and prognosis in primary myelofibrosis: Mayo‐Careggi MPN alliance study of 1,095 patients
Authors: Tefferi Ayalew , Nicolosi Maura , Mudireddy Mythri , Szuber Natasha , Finke Christy M. , Lasho Terra L. , Hanson Curtis A. , Ketterling Rhett P. , Pardanani Animesh , Gangat Naseema , Mannarelli Carmela , Fanelli Tiziana , Guglielmelli Paola , Vannucchi Alessandro M. 
Published: November 2017

AbstractThe 2013 discovery of calreticulin (CALR) mutations in myeloproliferative neoplasms was attended by their association with longer survival in primary myelofibrosis (PMF). Subsequent studies have suggested prognostic distinction between type 1/like and type 2/like CALR mutations and detrimental effect from triple‐negative mutational status. Among 709 Mayo Clinic patients with PMF, 467 (66%) harbored JAK2, 112 (16%) CALR type 1/like, 24 (3.4%) CALR type 2/like, 38 (5.4%) MPL mutations and 68 (10%) were triple‐negative. Survival was longer with type 1/like CALR, compared to JAK2 (HR 2.6, 95% CI 1.9‐3.5), type 2/like CALR (HR 2.5, 95% CI 1.4‐4.5), MPL (HR 1.8, 95% CI 1.1‐2.9) and triple‐negative mutational status (HR 2.4, 95% CI 1.6‐3.6), but otherwise similar between the non‐type 1/like CALR mutational states (P = .41). In multivariable analysis, the absence of type 1/like CALR (P < .001; HR 2, 95% CI 1.4‐2.7), presence of ASXL1/SRSF2 mutations (P < .001; HR 1.9, 95% CI 1.5‐2.4) and DIPSS‐plus (P < .001) were each predictive of inferior survival. Furthermore, among 210 patients with ASXL1/SRSF2 mutations, survival was significantly longer in the presence vs. absence of type 1/like CALR mutations (median 5.8 vs. 2.9 years; P < .001). Triple‐negative status did not disclose additional prognostic information for overall or leukemia‐free survival. The observations regarding the prognostic distinction between CALR mutation variants were validated in an external cohort of 386 patients from the University of Florence Careggi hospital. We conclude that type 1/like CALR mutations in PMF not only predict superior survival, but also partially amend the detrimental effect of high molecular risk mutations.
Surface energy of corona treated PP, PE and PET films, its alteration as function of storage time and the effect of various corona dosages on their bond strength after lamination
Authors: Lindner Martina , Rodler Norbert , Jesdinszki Marius , Schmid Markus , Sängerlaub Sven 
Published: November 2017

ABSTRACTThe aim of this study was to analyze how corona dosages above recommended levels affect film surface energy and hydrophobic recovery of such treated film surfaces as well as laminate bond strength of laminates made of these films. The adhesive for lamination was a polyurethane‐adhesive with a dry film thickness of ∼5 µm. Polar and dispersive parts of the surface energy were measured frequently according to DIN 55660‐2 (Owens–Wendt–Rabel‐and‐Kaelble method) for up to 140 days after corona treatment. The corona dosage had a value of up to 280 W min/m2. Laminate bond strength was measured according to DIN 55543‐5. The effect of corona treatment was highest for low‐density polyethylene (PE‐LD) films, mean for biaxial‐oriented polypropylene (PP‐BO) films, and lowest for biaxial‐oriented poly(ethylene terephthalate) (PET‐BO) films. With increasing storage time, surface energy decreased, as expected. The higher the effect of corona treatment, the faster the polar part of surface energy decreased. At PE‐LD, laminate bond strength increased with a higher corona dosage from 0.05 to 8.87 mN/15 mm, whereas at PET‐BO and PP‐BO laminate bond strength was so high that samples teared before delamination during bond strength testing. By our results is shown that corona dosages above recommended levels resulted in higher laminate bond strength. Only at PP‐BO a reduction of laminate bond strength due to “overtreatment” was be observed. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45842.
Compatibilization of the poly(lactic acid)/poly(propylene carbonate) blends through in situ formation of poly(lactic acid)‐b‐poly(propylene carbonate) copolymer
Authors: Wang Zhao , Zhang Min , Liu Zhengying , Zhang Shuyang , Cao Zhiqiang , Yang Wei , Yang Mingbo 
Published: November 2017

ABSTRACTThe in situ formation of poly(lactic acid)‐b‐poly(propylene carbonate) (PLA‐b‐PPC) block copolymers were carried out by the reaction between PLA and PPC in the presence of tetrabutyl titanate via transesterification. Molecular weight measurements and 13C nuclear magnetic resonance spectroscopy revealed that PLA‐b‐PPC block copolymers with higher molecular weight were obtained by controlling the reactivity point ratio between PLA chains and PPC chains in PLA/PPC reaction system. The sample with a composition of PLA:PPC = 40:60 (wt %) and a catalyst amount of 0.5 wt % had a more proportionable reactivity point ratio between PLA chains and PPC chains compared with other samples, resulting in a most conspicuous transesterification and inconspicuous chain scission reaction. Therefore, its high molecular weight fraction (Mw > 40.0 × 104) increased 80%. The formation of macromolecular PLA‐b‐PPC copolymer could strengthen the entanglement between PLA and PPC molecular chains, which resulted in an increased viscosity of blends at low shear rate. In addition, the elongation at break of sample with a composition of PLA:PPC = 40:60 (wt %) and a catalyst amount of 0.5 wt % was nearly as twice as which without catalyst because of the improving miscibility of PLA domains and PPC matrix by the compatibilization of PLA‐b‐PPC copolymer. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46009.
Interplay between physicochemical and mechanical properties of poly(ethylene terephthalate) meshes for hernia repair
Authors: Todros Silvia , Pavan Piero Giovanni , Pachera Paola , Pace Giuseppe , Di Noto Vito , Natali Arturo Nicola 
Published: November 2017

ABSTRACTNon‐medical‐grade industrial nets are often implemented in developing countries as affordable alternative to surgical meshes for hernia repair. Even if there is clear evidence about their repairing reliability, their physicochemical and mechanical properties have been not fully investigated. This works compares three industrial nets with different textile patterns, and a surgical mesh of the same polymer. Nets are autoclave‐sterilized and characterized through scanning electron microscope, Raman spectroscopy, thermogravimetric analysis , differential scanning calorimetry, and uniaxial tensile tests. Spectral and thermal analyses reveal that all samples are based on poly(ethylene terephthalate). Differences are found in phase conformations with modifications in amorphous, ordered amorphous, and crystalline domains. Changes in material characteristics do not affect mechanical properties, which are mainly ascribable to the textile pattern. Industrial nets show a stiffening behavior different from the almost linear anisotropic response of surgical mesh. However, non‐medical‐grade nets could be potentially applied for surgeries once their biocompatibility and in vivo stability have been evaluated. Non‐medical‐grade industrial nets are used as low‐cost alternative to surgical meshes for hernia repair in less developed countries. Nets sterilization modifies their phase conformation, due to the interaction with water, but do not affect mechanical properties. Even tough industrial nets show a different stiffening behavior, physicochemical characterization confirms a similarity to standard surgical meshes. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2018,135, 46014.
Therapeutic Effect of Curcumin and Methylprednisolone in the Rat Spinal Cord Injury
Authors: Liu Xuehong , Zhang Yong , Yang Yang , Lin Jingquan , Huo Xue , Du Xiaoxue , Botchway Benson O.A. , Fang Marong 
Published: November 2017

ABSTRACTIn addition to imperiling an individual's daily life, spinal cord injury (SCI), a catastrophic medical damage, can permanently impair an individual's body function. Methylprednisolone (MP), a medically accepted therapeutic drug for SCI, is highly controversial for the lack of consensus on its true therapeutic effect. In recent years, curcumin has served as a potential and novel therapeutic drug in SCI. Our study was intended to investigate the precise effect of MP and curcumin in SCI. We examined the function of MP and curcumin in a SCI model rat, both in vivo and in vitro, and found that there was a momentous improvement in Basso‐Beattie‐Bresnahan scores in the MP‐treated group when compared with Cur‐treated group within 14 days. Results obtained from the histological, immunohistochemistry and ultrastructural examinations evidenced the curative effect of MP was better than curcumin before Day 14. Nonetheless, there was a significant variation in the treatment effect between the MP‐treated and Cur‐treated groups after 14 days. The curcumin's effectiveness was more obvious than MP after 14 days following SCI. As such, we surmise that curcumin has a better therapeutic potential than MP with a prolong treatment time in the wake of SCI. Anat Rec, 301:686–696, 2018. © 2017 Wiley Periodicals, Inc.
cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate
Authors: Dey Antu K. , Cupo Albert , Ozorowski Gabriel , Sharma Vaneet K. , Behrens Anna‐Janina , Go Eden P. , Ketas Thomas J. , Yasmeen Anila , Klasse Per J. , Sayeed Eddy , Desaire Heather , Crispin Max , Wilson Ian A. , Sanders Rogier W. , Hassell Thomas , Ward Andrew B. , Moore John P. 
Published: November 2017

AbstractWe describe the properties of BG505 SOSIP.664 HIV‐1 envelope glycoprotein trimers produced under current Good Manufacturing Practice (cGMP) conditions. These proteins are the first of a new generation of native‐like trimers that are the basis for many structure‐guided immunogen development programs aimed at devising how to induce broadly neutralizing antibodies (bNAbs) to HIV‐1 by vaccination. The successful translation of this prototype demonstrates the feasibility of producing similar immunogens on an appropriate scale and of an acceptable quality for Phase I experimental medicine clinical trials. BG505 SOSIP.664 trimers are extensively glycosylated, contain numerous disulfide bonds and require proteolytic cleavage, all properties that pose a substantial challenge to cGMP production. Our strategy involved creating a stable CHO cell line that was adapted to serum‐free culture conditions to produce envelope glycoproteins. The trimers were then purified by chromatographic methods using a 2G12 bNAb affinity column and size‐exclusion chromatography. The chosen procedures allowed any adventitious viruses to be cleared from the final product to the required extent of >12 log10. The final cGMP production run yielded 3.52 g (peptidic mass) of fully purified trimers (Drug Substance) from a 200 L bioreactor, a notable yield for such a complex glycoprotein. The purified trimers were fully native‐like as judged by negative‐stain electron microscopy, and were stable over a multi‐month period at room temperature or below and for at least 1 week at 50°C. Their antigenicity, disulfide bond patterns, and glycan composition were consistent with trimers produced on a research laboratory scale. The methods reported here should pave the way for the cGMP production of other native‐like Env glycoprotein trimers of various designs and genotypes.