bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet Reactivity and Clinical Outcomes After Coronary Artery Implantation of Drug-Eluting Stents in Subjects With Peripheral Arterial Disease
Authors: Gupta Rajesh , Kirtane Ajay J. , Ozan M. Ozgu , Witzenbichler Bernhard , Rinaldi Michael J. , Metzger D. Christopher , Weisz Giora , Stuckey Thomas D. , Brodie Bruce R. , Mehran Roxana , Ben-Yehuda Ori , Stone Gregg W. 
Published: March 2017

Background—
Patients with peripheral arterial disease (PAD) have high rates of adverse cardiovascular events after percutaneous coronary intervention and may additionally have heightened platelet reactivity. This study assessed the relationship between platelet reactivity and clinical outcomes after percutaneous coronary interventions among subjects with and without PAD.

Methods and Results—
ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) was a prospective, multicenter registry of patients treated with coronary drug-eluting stents. Platelet reactivity was assessed by the VerifyNow point-of-care assay; high on-treatment platelet reactivity (HPR) was defined as P2Y12 reaction units >208. A propensity-adjusted multivariable analysis was performed to determine the relationship between PAD, platelet reactivity, and subsequent adverse events (definite or probable stent thrombosis, all-cause mortality, myocardial infarction, and clinically relevant bleeding). Among 8582 patients, 10.2% had a history of PAD. Patients with PAD were older and more likely to have comorbid conditions; however, mean P2Y12 reaction units and HPR were not significantly different between PAD and no PAD groups. Patients with PAD had higher 2-year rates of all-cause mortality, myocardial infarction, stent thrombosis, and clinically relevant bleeding. Associations between HPR and adverse events were similar in PAD and no PAD groups, without evidence of interaction; however, adverse event rates were highest among subjects with both PAD and HPR. In a propensity-adjusted multivariable model, both PAD and HPR were independent predictors of myocardial infarction at 2 years.

Conclusions—
A history of PAD was associated with ischemic and bleeding outcomes 2 years after successful coronary drug-eluting stent implantation; however, these associations did not seem to be directly mediated by heightened platelet reactivity.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00638794.
Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays
Authors: Trambas Christina , Lu Zhong , Yen Tina , Sikaris Ken 
Published: March 2017

Background Biotin interference is a significant problem to which at-risk laboratories must now be attuned. We sought to systematically characterize the nature of this interference in Roche immunoassays. Methods Known concentrations of biotin were titrated into serum samples and the effects on competitive and sandwich immunoassays were analysed. The maximum and minimum concentrations examined reflect those likely to be achieved in individuals on 5 to 10 mg supplements at the lower end, and 100 to 300 mg biotin at the high end. Results A high variability in biotin tolerance was observed. Some assays, such as troponin T, TSH and antithyroid antibodies, were extremely sensitive to the lower concentrations of biotin (15.6 and 31.3 ng/mL), whereas the majority of assays were relatively resistant. At concentrations ≥500 ng/mL, all assays showed significant interference from biotin but, again, the magnitude of the interference was variable. The more sensitive assays showed profound analytical bias at biotin concentrations that occur with high-dose therapy. Conclusion Our data demonstrate high variability in biotin tolerance across Roche immunoassays. The shape of the dose–response curves provides more detailed information than the single manufacturer-quoted figure for biotin tolerance. Accordingly, these data may be used by laboratories for more accurate risk assessment in predicting the effects of biotin. Our data may also be extrapolated to guide timing of blood tests in patients on high-dose biotin therapy: it demonstrates the number of half-lives required to withhold biotin in order to decrease its concentration to below a given assay tolerance.
Outcomes in Adult Sinonasal Rhabdomyosarcoma
Authors: Stepan Katelyn , Konuthula Neeraja , Khan Mohemmed , Parasher Arjun , Del Signore Anthony , Govindaraj Satish , Genden Eric , Iloreta Alfred 
Published: March 2017

ObjectiveTo describe patient demographics, histology, treatment modalities, and survival associated with adult sinonasal rhabdomyosarcoma.Study DesignRetrospective review of a national database.SettingTertiary medical center.Subjects and MethodsPatient demographics, tumor histology, treatment modalities, and survival trends were examined for patients aged ≥18 years who were diagnosed with sinonasal rhabdomyosarcoma between 2004 and 2013 with the National Cancer Database. Kaplan‐Meier analysis and the log‐rank tests were performed to determine the unadjusted association between overall survival and various patient and disease characteristics.ResultsA total of 186 patients were identified; 5‐year overall survival was 28.4%. Over half of patients were between 18 and 35 years old at diagnosis (53.8%), which was associated with improved 5‐year overall survival over patients >35 years old (31.9% vs 24.4%, P =. 014). Alveolar sinonasal rhabdomyosarcoma was most common (66.7%). There was no statistical difference in 5‐year overall survival between alveolar and embryonal subtypes (30.5% vs 41.6%, P >. 05). Metastatic disease was present in 27.7% of patients and was associated with worse 5‐year overall survival (14.7% vs 33.9%, P <. 0001). The majority of patients were treated with chemotherapy with adjuvant radiation (49.5%). A quarter of patients were treated with surgery plus chemoradiation (25.8%).ConclusionWe present the largest analysis of adult sinonasal rhabdomyosarcoma using a standardized national based database. Adult sinonasal rhabdomyosarcoma has a very poor prognosis independent of histologic subtype. The small number of surgical cases limits the ability of the analysis to accurately compare treatment with chemoradiation with and without surgery.
Inpatient Rounding Practices in Otolaryngology Residency Programs
Authors: Sokoya Mofiyinfolu , Judge Paul D. , Cabrera‐Muffly Cristina , Vila Peter M. 
Published: March 2017

Inpatient rounding is an agelong tradition in the field of medicine. Among recent changes in health care, rounding is understudied as an area of research. The purpose of this study was to assess current methods of inpatient rounding in otolaryngology residency programs and assess satisfaction with current practices. Survey questions were designed by members of the resident committee of the Society of University Otolaryngologists. Surveys were sent to all 450 members, and we obtained a 32% response rate. Sixty‐four percent of attendings perform bedside rounds; 44% of subjects reported that attending physicians participate in rounds at least once a week; and 21% reported daily participation. When asked if attending participation in rounding is adequate, attendings did not have a strong opinion (mean = 3.8). There is a paucity of research on inpatient rounding, and future studies should examine specific practices with the goal of maximizing patient safety and resident education.
Ne Bis in Idem as a Defence Right and Procedural Safeguard in the EU
Authors: Bravo Teresa 
Published: March 2017

This paper will focus on the ne bis in idem principle, in the AFSJ as a defence right and argues that emancipating this principle from the conflict of jurisdictions debate will increase the status of defence rights in the EU and enhance its dimension as a procedural safeguard. Article 82(2), b) of the TFEU paves the way to harmonisation of procedural safeguards, on an EU level, and can also be understood as a means to create a “common legal grammar” between Member States. Consequently, European legislation regarding ne bis in idem would not only bring legal certainty but it also contributes to diminishing the grounds of refusal as far as mutual recognition legal instruments are concerned. The need for a deontic European model regarding defence rights and procedural safeguards is also in discussion as it would serve as a counterweight between the two dimensions of European integration, in the AFSJ: freedom and security.
Historical Development of Penitentiary Legislation in Albania
Authors: Gashi Rexhep 
Published: March 2017

This paper presents and analyzes the historical development of penitentiary legislation in Albania during the communist dictatorship and the period after the establishment of political pluralism and the victory of democracy in Albania. During the communist dictatorship from 1944–1991, the legal regulation of the system of imprisonment for crimes committed was defective, and this led to arbitrary and abusive conduct on the part of the authorities. Where there was regulation it was largely politicized and ideologized and was therefore a powerful weapon in the hands of the proletarian dictatorship. Also, during this time and up to the advance to democracy in Albania, a large number of prisons and labour camps were operated whose inmates were predominantly political prisoners. In the period after the establishment of political pluralism and the advent in 1991 of Albania's fragile democracy until today, a considerable number of legal acts governing incarceration as a punishment have been approved. Also several conventions and other international acts in the field of fundamental freedoms and human rights, including rights of convicted persons have been ratified. But despite some tangible results this legislation has not led to acceptable penitentiary practices.
To Continue or Not: Who Shall Be in Control of the European Public Prosecutor's Dismissal Decisions?
Authors: Göhler Johanna 
Published: March 2017

This article intends to present a comprehensive framework for a regime of judicial review on dismissal decisions taken by a future European Public Prosecutor's Office (EPPO). To clearly outline the process of this judicial review the article poses and analyses several underlying issues. First, will a supranational solution be superior to the application of the Member States' individual review systems? If a supranational solution is approved, which legal basis can serve as the foundation for this supranational regime and on which theoretical foundation should it be based? Finally, who should be granted standing to request a review? It is suggested that judicial review might be enacted on a supranational level. Standing should be granted to EU citizens with an identifiable status in a particular case and to defined groups with a recognised status. The review shall confirm the legality of prosecutorial decisions and maintain public confidence in the EPPO.
Crossed fused renal ectopia in a Persian cat
Authors: Seo Sang-Hyuk , Lee Hyun-A , Suh Sang-Il , Choi Ran , Park In-Chul , Hyun Changbaig 
Published: March 2017

Case summary This report describes a rare case of crossed fused renal ectopia (CFRE) in a cat. A mature intact male Persian cat presented with bloody nasal discharge and ascites. Diagnostic studies revealed an ectopic left kidney fused with an orthotopic right kidney and a concurrent feline infectious peritonitis (FIP) infection. The FIP was responsible for clinical signs in this cat, while clinical signs associated with CFRE were not obvious. Despite receiving intensive treatment, the cat died. A post-mortem examination was not performed because the owners declined approval. Relevance and novel information To the best of our knowledge, this is the first report of L-shaped CFRE in a cat. In addition, this report describes the CT features of L-shaped CFRE in a cat.
The h-Index of Editorial Board Members Correlates Positively With the Impact Factor of Sports Medicine Journals
Authors: Kay Jeffrey , Memon Muzammil , de SA Darren , Simunovic Nicole , Duong Andrew , Karlsson Jon , Ayeni Olufemi Rolland 
Published: March 2017

Background: The h-index is a metric widely used to present both the productivity and impact of an author’s previous publications. Purpose: To evaluate and observe any correlations among the h-indices of 2015 editorial board members from 8 top sports medicine journals. Study Design: Systematic review. Methods: The sex, country of residence, degree, and faculty position of the editorial board members were identified using their respective scientific publication profiles. The h-index and other bibliometric indicators of these editorial board members were obtained using both the Web of Science (WoS) and Google Scholar (GS) databases. Nonparametric statistics were used to analyze differences in h-index values, and regression models were used to assess the ability of the editorial board member’s h-index to predict their journal’s impact factor (IF). Results: A total of 422 editorial board members were evaluated. The median h-index of all editors was 20 (interquartile range [IQR], 19) using GS and 15 (IQR, 15) using WoS. GS h-index values were 1.19 times higher than WoS, with significant correlation between these values ( r2 = 0.88, P = .0001). Editorial board members with a PhD had significantly higher h-indices than those without (GS, P = .0007; WoS, P = .0002), and full professors had higher h-indices than associate and assistant professors (GS, P = .0001; WoS, P = .0001). Overall, there were significant differences in the distribution of the GS ( P < .0001) and WoS ( P < .0001) h-indices of the editorial board members by 2014 IF of the journals. Both the GS h-index (β coefficient, 0.01228; 95% CI, 0.01035-0.01423; P < .0001) as well as the WoS h-index (β coefficient, 0.01507; 95% CI, 0.01265-0.01749; P < .0001) of editorial board members were significant predictors of the 2014 IF of their journal. Conclusion: The h-indices of editorial board members of top sports medicine journals are significant predictors of the IF of their respective journals.
Surgical treatment algorithms for post-burn contractures
Authors: Hayashida Kenji , Akita Sadanori 
Published: March 2017

Abstract
Burn contractures produce restrictions in motion and unacceptable aesthetic results, frequently with persistent wounds. Proper planning and tissue selection are essential to minimize donor site morbidity optimizing outcomes. The principle of burn reconstructive surgery requires that the defects after release should be replaced with donor tissues which have matching texture and color as well as enough pliability. Autologous skin grafting or flap surgeries meet these criteria to replace scar tissues and resurface the subsequent to post-released scar defects. Despite the benefits, the use of flaps is often limited in burn patients for many reasons. If a surgeon intends to release completely and reconstruct in one-stage operation, a large defect may result in large donor site morbidity, necessitating flap surgery including free flap surgery. A lot of different methods and procedures are available for resurfacing the defects, and these are reviewed. In this article, algorithms for the release of burn contractures and reconstructive methods are presented. These treatment algorithms should aid in achieving significant improvement in both joint motions and aesthetic deformities.
Ultrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results
Authors: Willmann Jürgen K. , Bonomo Lorenzo , Testa Antonia Carla , Rinaldi Pierluigi , Rindi Guido , Valluru Keerthi S. , Petrone Gianluigi , Martini Maurizio , Lutz Amelie M. , Gambhir Sanjiv S. 
Published: March 2017

Purpose We performed a first-in-human clinical trial on ultrasound molecular imaging (USMI) in patients with breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR] –targeted contrast microbubble [MBKDR]) that is targeted at the KDR, one of the key regulators of neoangiogenesis in cancer. The aim of this study was to assess whether USMI using MBKDR is safe and allows assessment of KDR expression using immunohistochemistry (IHC) as the gold standard. Methods Twenty-four women (age 48 to 79 years) with focal ovarian lesions and 21 women (age 34 to 66 years) with focal breast lesions were injected intravenously with MBKDR (0.03 to 0.08 mL/kg of body weight), and USMI of the lesions was performed starting 5 minutes after injection up to 29 minutes. Blood pressure, ECG, oxygen levels, heart rate, CBC, and metabolic panel were obtained before and after MBKDR administration. Persistent focal MBKDR binding on USMI was assessed. Patients underwent surgical resection of the target lesions, and tissues were stained for CD31 and KDR by IHC. Results USMI with MBKDR was well tolerated by all patients without safety concerns. Among the 40 patients included in the analysis, KDR expression on IHC matched well with imaging signal on USMI in 93% of breast and 85% of ovarian malignant lesions. Strong KDR-targeted USMI signal was present in 77% of malignant ovarian lesions, with no targeted signal seen in 78% of benign ovarian lesions. Similarly, strong targeted signal was seen in 93% of malignant breast lesions with no targeted signal present in 67% of benign breast lesions. Conclusion USMI with MBKDR is clinically feasible and safe, and KDR-targeted USMI signal matches well with KDR expression on IHC. This study lays the foundation for a new field of clinical USMI in cancer.
Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer
Authors: Greenup Rachel A. , Blitzblau Rachel C. , Houck Kevin L. , Sosa Julie Ann , Horton Janet , Peppercorn Jeffrey M. , Taghian Alphonse G. , Smith Barbara L. , Hwang E. Shelley 
Published: March 2017

Introduction: Breast cancer treatment costs are rising, and identification of high-value oncology treatment strategies is increasingly needed. We sought to determine the potential cost savings associated with an evidence-based radiation treatment (RT) approach among women with early-stage breast cancer treated in the United States. Patients and Methods: Using the National Cancer Database, we identified women with T1-T2 N0 invasive breast cancers treated with lumpectomy during 2011. Adjuvant RT regimens were categorized as conventionally fractionated whole-breast irradiation, hypofractionated whole-breast irradiation, and omission of RT. National RT patterns were determined, and RT costs were estimated using the Medicare Physician Fee Schedule. Results: Within the 43,247 patient cohort, 64% (n = 27,697) received conventional RT, 13.3% (n = 5,724) received hypofractionated RT, 1.1% (n = 477) received accelerated partial-breast irradiation, and 21.6% (n = 9,349) received no RT. Among patients who were eligible for shorter RT or omission of RT, 57% underwent treatment with longer, more costly regimens. Estimated RT expenditures of the national cohort approximated $420.2 million during 2011, compared with $256.2 million had women been treated with the least expensive regimens for which they were safely eligible. This demonstrated a potential annual savings of $164.0 million, a 39% reduction in associated treatment costs. Conclusion: Among women with early-stage breast cancer after lumpectomy, use of an evidence-based approach illustrates an example of high-value care within oncology. Identification of high-value cancer treatment strategies is critically important to maintaining excellence in cancer care while reducing health care expenditures.
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo
Authors: Pievani Alice , Sacchetti Benedetto , Corsi Alessandro , Rambaldi Benedetta , Donsante Samantha , Scagliotti Valeria , Vergani Patrizia , Remoli Cristina , Biondi Andrea , Robey Pamela G. , Riminucci Mara , Serafini Marta 
Published: March 2017

ABSTRACT
Human umbilical cord blood (CB) has attracted much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs). Previously, we demonstrated that bone marrow stromal cell (BMSC) and CB-BF pellet cultures make cartilage in vitro. Furthermore, upon in vivo transplantation, BMSC pellets remodelled into miniature bone/marrow organoids. Using this in vivo model, we asked whether CB-BF populations that express characteristics of the hematopoietic stem cell (HSC) niche contain precursors that reform the niche. CB ossicles were regularly observed upon transplantation. Compared with BM ossicles, CB ossicles showed a predominance of red marrow over yellow marrow, as demonstrated by histomorphological analyses and the number of hematopoietic cells isolated within ossicles. Marrow cavities from CB and BM ossicles included donor-derived CD146-expressing osteoprogenitors and host-derived mature hematopoietic cells, clonogenic lineage-committed progenitors and HSCs. Furthermore, human CD34+ cells transplanted into ossicle-bearing mice engrafted and maintained human HSCs in the niche. Our data indicate that CB-BFs are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete HSC niches, which are functionally supportive of hematopoietic tissue.