bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lowering the burden: Shorter versions of the Program Sustainability Assessment Tool (PSAT) and Clinical Sustainability Assessment Tool (CSAT)
Authors: Malone Sara , Prewitt Kim , McKay Virginia , Zabotka Luke , Bacon Caren , Luke Douglas A. 
Published: October 2024

Abstract
Background
Although significant advances have been made in the conceptualization of sustainability, having pragmatic, psychometrically valid tools remains a need within the field. Our previous work has developed frameworks and tools to assess both program sustainability and clinical sustainability capacity. This work presents new, psychometrically tested short versions of the Program Sustainability Assessment Tool (PSAT) and the Clinical Sustainability Assessment Tool (CSAT).

Methods
These methods were conducted in identical, parallel processes for the CSAT and PSAT. Previously collected data for these instruments was obtained across a variety of settings, contexts, and participants. We first conducted testing to determine cronbach’s alpha of shortened domains (3 items each) and then conducted Confirmatory Factor Analysis to ensure that the domains were still appropriate for the tool. After, the team met to review the results and determine the final versions of the short PSAT and short CSAT.

Results
The short PSAT retained cronbach’s alpha’s of 0.82 – 0.91 for each domain of the tool, with which maintains excellent reliability for the tool. Confirmatory factor analysis highlights that the short PSAT retains conceptual distinction across the 8 domains, with CFI scores greater than 0.90, RMSEA scores below 0.6, and SRMR scores less than 0.08. The short CSAT had cronbach’s alpha of 0.84 – 0.92 for each of the domains of the tool, also suggesting excellent reliability of the domains within the measure after dropping two items/domain. Confirmatory factor analysis of the short CSAT meets the same specifications as above, again highlighting conceptual distinction across the domains.

Conclusion
Each tool was able to be shortened to three items per domain while maintaining strong psychometric properties. This results in a tool that takes less time to complete, meeting one of the key calls for pragmatic measures within implementation science. This advances our abilities to measure and test sustainability within implementation science.
Interdisciplinary advances in microcombs: bridging physics and information technology
Authors: Yao Bai-Cheng , Wang Wen-Ting , Xie Zhen-Da , Zhou Qiang , Tan Teng , Zhou Heng , Guo Guang-Can , Zhu Shi-Ning , Zhu Ning-Hua , Wong Chee Wei 
Published: October 2024

AbstractThe advancement of microcomb sources, which serve as a versatile and powerful platform for various time–frequency measurements, have spurred widespread interest across disciplines. Their uses span coherent optical and microwave communications, atomic clocks, high-precision LiDARs, spectrometers, and frequency synthesizers. Recent breakthroughs in fabricating optical micro-cavities, along with the excitation and control of microcombs, have broadened their applications, bridging the gap between physical exploration and practical engineering systems. These developments pave the way for pioneering approaches in both classical and quantum information sciences. In this review article, we conduct a thorough examination of the latest strategies related to microcombs, their enhancement and functionalization schemes, and cutting-edge applications that cover signal generation, data transmission, quantum analysis, and information gathering, processing and computation. Additionally, we provide in-depth evaluations of microcomb-based methodologies tailored for a variety of applications. To conclude, we consider the current state of research and suggest a prospective roadmap that could transition microcomb technology from laboratory settings to broader real-world applications.
Efficient microresonator frequency combs
Authors: Yang Qi-Fan , Hu Yaowen , Torres-Company Victor , Vahala Kerry 
Published: October 2024

AbstractThe rapid development of optical frequency combs from their table-top origins towards chip-scale platforms has opened up exciting possibilities for comb functionalities outside laboratories. Enhanced nonlinear processes in microresonators have emerged as a mainstream comb-generating mechanism with compelling advantages in size, weight, and power consumption. The established understanding of gain and loss in nonlinear microresonators, along with recently developed ultralow-loss nonlinear photonic circuitry, has boosted the optical energy conversion efficiency of microresonator frequency comb (microcomb) devices from below a few percent to above 50%. This review summarizes the latest advances in novel photonic devices and pumping strategies that contribute to these milestones of microcomb efficiency. The resulting benefits for high-performance integration of comb applications are also discussed before summarizing the remaining challenges.
Second-Generation Supraglottic Airway Devices Versus Endotracheal Intubation in Adults Undergoing Abdominopelvic Surgery: A Systematic Review and Meta-Analysis
Authors: de Carvalho Clístenes Crístian , Kapsokalyvas Ioannis , El-Boghdadly Kariem 
Published: October 2024

BACKGROUND:
Second-generation supraglottic airway (SGA) devices are widely used, but thought to have inferior safety performance to endotracheal tubes (ETTs), but might be equally efficacious while improving patient-centered outcomes. We compared second-generation SGAs with ETTs for perioperative safety, efficacy, and quality of recovery in adults undergoing abdominopelvic surgery under general anesthesia. Our primary objective was to assess safety in the form of major airway complications. Secondary objectives were other safety, efficacy, and quality of recovery outcomes.

METHODS:
We searched 4 databases for randomized controlled trials of adult patients having abdominopelvic surgery comparing second-generation SGAs and ETTs. After 2-person screening and data extraction, pairwise meta-analysis was conducted and the grading of recommendations, assessment, development, and evaluation (GRADE) approach was applied to assess the certainty of evidence.

RESULTS:
A total of 51 studies, randomizing 5110 patients, were included. Second-generation SGAs significantly reduced the risk of major perioperative airway complications (risk ratio [RR], 0.41; 95% confidence interval [CI], 0.23–0.71; P = .007; low certainty), with no clear clinically relevant difference in regurgitation or pulmonary aspiration (low certainty). SGAs significantly increased the risk of inadequate ventilation (RR, 3.36; 95% CI, 1.43–7.89; P = .011; very low certainty); however, postoperative sore throat (RR, 0.52; 95% CI, 0.38–0.70; P < .001; moderate certainty), hoarseness (RR, 0.32; 95% CI, 0.231–0.48; P < .001; low certainty), coughing at the emergence of anesthesia (RR, 0.17; 95% CI, 0.08–0.36; P < .001; low certainty), and postoperative nausea and vomiting (RR, 0.64; 95% CI, 0.42–0.98; P = .042; very low certainty) were all less frequent with SGAs. No other clinically relevant differences were observed for other remaining outcomes.

CONCLUSIONS:
Second-generation SGAs reduce the risk of major airway complications compared with ETTs in adults undergoing abdominopelvic procedures under general anesthesia, with no reported clinically relevant differences in the risk of regurgitation or pulmonary aspiration. Additionally, they improve the quality of postoperative recovery with lower risk of sore throat, hoarseness, and postoperative nausea and vomiting. These data provide an opportunity for clinicians to reassess the implications of conservative airway management, and potentially expand the role of second-generation SGAs in routine clinical practice.
Characterization of alternative splicing during mammalian brain development reveals the extent of isoform diversity and potential effects on protein structural changes
Authors: Haj Abdullah Alieh Leila , Cardoso de Toledo Beatriz , Hadarovich Anna , Toth-Petroczy Agnes , Calegari Federico 
Published: October 2024

ABSTRACT
Regulation of gene expression is critical for fate commitment of stem and progenitor cells during tissue formation. In the context of mammalian brain development, a plethora of studies have described how changes in the expression of individual genes characterize cell types across ontogeny and phylogeny. However, little attention has been paid to the fact that different transcripts can arise from any given gene through alternative splicing (AS). Considered a key mechanism expanding transcriptome diversity during evolution, assessing the full potential of AS on isoform diversity and protein function has been notoriously difficult. Here, we capitalize on the use of a validated reporter mouse line to isolate neural stem cells, neurogenic progenitors and neurons during corticogenesis and combine the use of short- and long-read sequencing to reconstruct the full transcriptome diversity characterizing neurogenic commitment. Extending available transcriptional profiles of the mammalian brain by nearly 50,000 new isoforms, we found that neurogenic commitment is characterized by a progressive increase in exon inclusion resulting in the profound remodeling of the transcriptional profile of specific cortical cell types. Most importantly, we computationally infer the biological significance of AS on protein structure by using AlphaFold2, revealing how radical protein conformational changes can arise from subtle changes in isoforms sequence. Together, our study reveals that AS has a greater potential to impact protein diversity and function than previously thought, independently from changes in gene expression.
Differentiation of CD166-positive hPSC-derived lung progenitors into airway epithelial cells
Authors: Goh Kim Jee , Lu Hao , Tan Ee Kim , Lee Zhao Yong , Wong Amanda , Tran Thai , Dunn N. Ray , Roy Sudipto 
Published: October 2024

ABSTRACT
The generation of lung epithelial cells through the directed differentiation of human pluripotent stem cells (hPSCs) in vitro provides a platform to model both embryonic lung development and adult airway disease. Here, we describe a robust differentiation protocol that closely recapitulates human embryonic lung development. Differentiating cells progress through obligate intermediate stages, beginning with definitive endoderm formation and then patterning into anterior foregut endoderm that yields lung progenitors (LPs) with extended culture. These LPs can be purified using the cell surface marker CD166 (also known as ALCAM), and further matured into proximal airway epithelial cells including basal cells, secretory cells and multiciliated cells using either an organoid platform or culture at the air-liquid interface (ALI). We additionally demonstrate that these hPSC-derived airway epithelial cells can be used to model Influenza A infection. Collectively, our results underscore the utility of CD166 expression for the efficient enrichment of LPs from heterogenous differentiation cultures and the ability of these isolated cells to mature into more specialized, physiologically relevant proximal lung cell types.
Spatial arrangement of the whiskers of harbor seals (Phoca vitulina) compared with whisker arrangements of house mice (Mus musculus) and brown rats (Rattus norvegicus)
Authors: Graff Matthew M. , Belli Hayley M. , Wieskotten Sven , Bresee Chris S. , Krüger Yvonne , Janssen Thomas L. , Dehnhardt Guido , Hartmann Mitra J. Z. 
Published: October 2024

ABSTRACT
Whiskers (vibrissae) are important tactile sensors for most mammals. We introduce a novel approach to quantitatively compare 3D geometry of whisker arrays across species with different whisker numbers and arrangements, focusing on harbor seals (Phoca vitulina), house mice (Mus musculus) and Norway rats (Rattus norvegicus). Whiskers of all three species decrease in arclength and increase in curvature from caudal to rostral. They emerge from the face with elevation angles that vary linearly with dorsoventral position, and with curvature orientations that vary diagonally as linear combinations of dorsoventral and rostrocaudal positions. In seals, this diagonal varies linearly with horizontal emergence angles, and is orthogonal to the diagonal for rats and mice. This work provides the first evidence for common elements of whisker arrangements across species in different mammalian orders. Placing the whisker array model on a CAD model of a seal head enables future mechanical studies of whisker-based sensing, including wake tracking.
Some Interfacial Interactions between Isocyanates and Metals that Affect Release in Composite Wood-Panel Production*
Authors: Phanopoulos Christopher , Holvoet Servaas , Pratelli Daniele , Pans Griet , Shimizu Kyoko , Ng Simon , Bañuls-Ciscar Jorge , Abel Marie-Laure , Watts John F. 
Published: October 2024

Abstract
Isocyanate- and polyurethane-based adhesives for composite wood-panel production are well known. They are useful for the manufacture of high-performance assemblies, particularly for moisture resistance, durability, and strength. However, isocyanate-based adhesives have several opportunities for improvements related to composite panel manufacture. Of particular note is the ability of isocyanates to bond, not only to wood, but to metal press platens used to produce the composite panels. Although several methodologies exist to overcome this, there is a lack of understanding of the nature of the interactions between isocyanates and metal. The purpose of the current study was to provide insights into these interactions and to help to develop strategies for releasable isocyanate-based resins.
Variable-thickness isocyanate–metal and metal–wood assemblies were prepared and the interface exposed by various methods, e.g., surface analysis combined with cluster beam etching and simple peel tests. The interfaces were then analyzed by X-ray photoelectron spectroscopy or time-of-flight–secondary ion mass spectrometry (or both). These surface analytical methods have revealed several chemical interactions between the isocyanates and the metal surfaces, including carbamate-type links and metal–nitrogen linkages. Further, the surface analysis has revealed the compositional character of the locus of failure in wood–metal joints. The locus of failure depends on the presence of wood extractives. With nonextracted wood, the locus of failure is within the wood, which is characterized by a certain concentration of the penetrated resin. With solvent-extracted wood, the locus of failure is within the glue line.
High-definition quadriwave lateral shearing interferometry
Authors: Wattellier Benoit , Saintoyant Anaïs , Savatier Julien , de Laulanie Lucie , Aknoun Sherazade , Zinchuk Roman , Monneret Serge 
Published: October 2024

We present an evolution of quadriwave lateral shearing interferometry that improves the definition of quantitative phase images. It is now possible to produce images with as many pixels as the camera that records the interferogram. This is done by moving a diffraction grating in front of the camera and linearly combining at least nine acquisitions. In this paper, we present the principle of this technique and illustrate it by several examples acquired on a microscope with both calibrated and biological samples. We demonstrate the possibility of producing quantitative phase images with 5.5 million pixels, which are to our knowledge the largest images ever produced by a wavefront sensor.
Strain-concentration for fast, compact photonic modulation and non-volatile memory
Authors: Wen Y. Henry , Heim David , Zimmermann Matthew , Shugayev Roman A. , Dong Mark , Leenheer Andrew J. , Gilbert Gerald , Heuck Mikkel , Eichenfield Matt , Englund Dirk R. 
Published: October 2024

A critical figure of merit (FoM) for electro-optic (EO) modulators is the transmission change per voltage, dT/dV. Conventional approaches in wave-guided modulators maximize dT/dV via a high EO coefficient or longer light-material interaction lengths but are ultimately limited by material losses and nonlinearities. Optical and RF resonances improve dT/dV at the cost of spectral non-uniformity, especially for high-Q optical cavity resonances. Here, we introduce an EO modulator based on piezo-strain-concentration of a photonic crystal cavity to address both trade-offs: (i) it eliminates the trade-off between dT/dV and waveguide loss—i.e., enhancement of the resonance tuning efficiency dv
c
/dV for the fixed EO coefficient, waveguide length, and cavity Q—and (ii) at high DC strains it exhibits a non-volatile (NV) cavity tuning Δvc,NV for passive memory and programming of multiple devices into resonance despite fabrication variations. The device is fabricated on a scalable silicon nitride-on-aluminum nitride platform. We measure dv
c
/dV=177±1MHz/V, corresponding to Δv
c
=40±0.32GHz for a voltage spanning ±120V with an energy consumption of δU/Δv
c
=0.17nW/GHz. The modulation bandwidth is flat up to ωBW,3dB/2π=3.2±0.07MHz for broadband DC-AC and 142±17MHz for resonant operation near a 2.8 GHz mechanical resonance. Optical extinction up to 25 dB is obtained via Fano-type interference. Strain-induced beam-buckling modes are programmable under a “read-write” protocol with a continuous, repeatable tuning range of 5±0.25GHz, allowing for storage and retrieval, which we quantify with mutual information of 2.4 bits and a maximum non-volatile excursion of 8 GHz. Using a full piezo-optical finite-element-model (FEM) we identify key design principles for optimizing strain-based modulators and chart a path towards achieving performance comparable to lithium niobate-based modulators and the study of high strain physics on-chip.
Phosphorus modifies the association between body mass index and uric acid: Results from NHANES 2007–2018
Authors: Chen Yue , Luo Jing , Ma Xiao-Man , He Xiang-Ping , Zhang Wan-Lin , Wu Shao-Yong , Mo Xiao-Chun , Huang Wei-Chao , Guo Xu-Guang 
Published: October 2024

Introduction
Studies in recent years have shown that high uric acid causes harm to the human body, which has become a serious public health problem. Elevated serum uric acid has been shown to be associated with obesity, but the relationship between BMI and uric acid (UA) remains controversial. Although the association between BMI and UA has been well studied, the effect of phosphorus levels in vivo on this association remains unclear. This study aimed to determine the relationship between BMI and serum uric acid and the effect of phosphorus on the relationship between the two.

Research design and methods
The present study analyzed data from the National Health and Nutrition Examination Survey (NHANES) continuous 2007–2018 cycle. We included 10786 participants aged 20 years and over. Multivariable linear regression was performed to assess the association between BMI and serum uric acid. phosphorus was stratified into low phosphorus (<3.3 mg/dl), middle phosphorus (3.3–3.9 mg/dl) and high phosphorus (>3.9 mg/dl). Correction of the effect of phosphorus was assessed by testing the interaction between BMI and UA in multivariate linear regression.

Results
In this cross-sectional study, we found that BMI was positively associated with UA in the female population but not significantly in the male population or in the total population. In multiple regression analysis, UA was 0.51 higher in the highest female BMI group than in the lowest group (p = 0.0001). The relationship between BMI and UA differed significantly by gender under the influence of phosphorus, with men and women in Model II having a greater elevation of UA in men than in women within most groups. (BMI >30, phosphorus >3.9 mg/dl, β:0.83 95% CI: 0.43, 1.23 vs β: 0.79 95% CI: 0.30, 1.29). In addition, phosphorus significantly altered the positive association between BMI and UA in most models.

Conclusion
Our results indicate significant associations between BMI and uric acid in women, with higher BMI values likely to be associated with a higher risk of hyperuricemia, suggesting that uric acid levels in obese people should be closely monitored in clinical practice. Phosphorus and BMI have an interactive effect in elevating UA and should be noted as indicators of phosphorus in clinical practice.
Risk of systemic lupus erythematosus flare after COVID-19 hospitalization: A matched cohort study
Authors: Mageau Arthur , Géradin Christel , Sallah Kankoé , Papo Thomas , Sacre Karim , Timsit Jean-François 
Published: October 2024

Objective
To analyze the risk of systemic lupus erythematosus (SLE) flare after admission for COVID-19.

Methods
We performed a matched cohort study using the Assistance Publique—Hôpitaux de Paris Clinical Data Warehouse which collects structured medical, biological and administrative information from 11 million patients in Paris area, France. Each SLE patient hospitalized with a COVID-19 diagnosis code between March 2020 and December 2021 was matched to one SLE control patient with an exact matching procedure using age ±3 years, gender, chronic kidney disease, end-stage renal disease, and serological activity. The main outcome was a lupus flare during the 6 months follow-up. A flare was considered if a) documented by the treating physician in the patient’s EHR and b) justifying a change in SLE treatment. The electronic health records (EHRs) were individually checked for data accuracy.

Results
Among 4,533 SLE patients retrieved from the database, 81 (2.8%) have been admitted for COVID-19 between March 2020 and December 31, 2021, and 79 (n = 79/81,97.5%) were matched to a unique unexposed SLE. During follow-up, a flare occurred in 14 (17.7%) patients from the COVID-19 group as compared to 5 (6.3%) in the unexposed control group, including 4 lupus nephritis in the exposed group and 1 in the control group. After adjusting for HCQ use at index date and history of lupus nephritis, the risk of flare was higher in exposed SLE patients (hazard ratio [95% confidence interval] of 3.79 [1.49–9.65]).

Conclusions
COVID-19 hospitalization is associated with an increased risk of flare in SLE.
Analisis Determinan Konsentrasi Spasial Industri Manufaktur Menengah Besar Indonesia: Studi Kasus Pulau Jawa 2008-2018
Authors: Novia Selly 
Published: October 2024

This study aims to explain the spatial concentration and the factors that influence the spatial concentration of medium and large manufacturing industries in Java. In the period 2008 to 2018 the manufacturing industry sector contributed about 22% of Indonesia's GDP. This is evidence that the manufacturing industry is the leading sector and the main key in growing the national economy. Java Island is designated as a national growth center by the Master Plan for the Acceleration and Expansion of Indonesian Economic Development (MP3I) where Java Island is a driving force for national industry and services because of the great potential possessed by each province on the island. Analysis of industrial spatial concentration conditions was carried out using the Ellison-Glaeser Index and LQ. The data used is data on the number of large and medium industrial workers according to the two-digit code KBLI 2005 and 2009 at the provincial level on Java Island from 2008 to 2018. The results of the analysis show that the condition of large and medium industries is most concentrated in the tobacco processing industry and scattered industries, namely the rubber industry and plastic products. Analysis of the factors that affect spatial concentration in Java is done by analyzing panel data. The data used is secondary data sourced from the Badan Pusat Statistik (BPS), with cross-sectional data consisting of 6 provinces in Java and time-series data from 2008-2018. The analytical tool used in estimating the regression model in this study is Ordinary Least Square (OLS). The results of this study found that the labor productivity variable had a positive effect on spatial concentration. Meanwhile, the competition index and the provincial minimum wage have a negative effect on the spatial concentration of large and medium manufacturing industries in Java.