bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microclimatic temperatures increase the potential for vector-borne disease transmission in the Scandinavian climate
Authors: Haider Najmul , Kirkeby Carsten , Kristensen Birgit , Kjær Lene Jung , Sørensen Jens Havskov , Bødker Rene 
Published: August 2017

AbstractWe quantified the difference between the meteorological temperature recorded by the Danish Meteorological Institute (DMI) weather stations and the actual microclimatic temperatures at two or three different heights at six potential insect habitats. We then compared the impact of the hourly temperature on the extrinsic incubation period (EIP) of six pathogens. Finally, we developed a regression model, enabling us to predict the microclimatic temperatures of different habitats based on five standard meteorological parameters readily available from any meteorological institution. Microclimatic habitats were on average 3.5–5 °C warmer than the DMI recorded temperatures during midday and 1–3 °C cooler at midnight. The estimated EIP for five of the six microclimatic habitats was shorter than the estimates based on DMI temperatures for all pathogens studied. The microclimatic temperatures also predicted a longer season for virus development compared to DMI temperatures. Based on DMI data of hourly temperature, solar radiation, wind speed, rain and humidity, we were able to predict the microclimatic temperature of different habitats with an R2 of 0.87–0.96. Using only meteorological temperatures for vector-borne disease transmission models may substantially underestimate both the daily potential for virus development and the duration of the potential transmission season.
Impact of Ocean Warming on Tropical Cyclone Size and Its Destructiveness
Authors: Sun Yuan , Zhong Zhong , Li Tim , Yi Lan , Hu Yijia , Wan Hongchao , Chen Haishan , Liao Qianfeng , Ma Chen , Li Qihua 
Published: August 2017

AbstractThe response of tropical cyclone (TC) destructive potential to global warming is an open issue. A number of previous studies have ignored the effect of TC size change in the context of global warming, which resulted in a significant underestimation of the TC destructive potential. The lack of reliable and consistent historical data on TC size limits the confident estimation of the linkage between the observed trend in TC size and that in sea surface temperature (SST) under the background of global climate warming. A regional atmospheric model is used in the present study to investigate the response of TC size and TC destructive potential to increases in SST. The results show that a large-scale ocean warming can lead to not only TC intensification but also TC expansion. The TC size increase in response to the ocean warming is possibly attributed to the increase in atmospheric convective instability in the TC outer region below the middle troposphere, which facilitates the local development of grid-scale ascending motion, low-level convergence and the acceleration of tangential winds. The numerical results indicate that TCs will become stronger, larger, and unexpectedly more destructive under global warming.
The Link between ENSO-like Forcing and Hydroclimate Variability of Coastal East Asia during the Last Millennium
Authors: Park Jungjae , Han Jiwoo , Jin Qiuhong , Bahk Junbeom , Yi Sangheon 
Published: August 2017

AbstractInconsistent reconstructions of East Asian hydroclimate for the last millennium significantly limit our understanding of the mechanisms behind climate variability during the medieval climate anomaly (MCA) and little ice age (LIA) in the region. In this study, we present new high-resolution multiproxy records (diatom, δ13C, C/N, TS) from the Mulyoungari swamp, Jeju Island, South Korea. Our results indicate that El Niño southern oscillation-like variations caused the dry MCA/wet LIA pattern in the study area. Recent paleo-ENSO studies generally support the hypothesis that the MCA was characterized by more persistent El Niño-like conditions. During El Niño events, the genesis of typhoons affecting coastal East Asia tends to diminish because of warm anomalies of eastern tropical Pacific (ETP) SSTs and downward motions over the western tropical Pacific. Therefore, coastal East Asia likely experienced a decline in typhoon-related precipitation during the MCA, in contrast to monsoon-dominated northern China. Our results additionally imply that SST anomalies in the ETP need to be carefully checked to better understand current hydroclimate variability in coastal East Asia, one of the most populated areas on earth.
Identification of novel microRNAs in the sheep heart and their regulation in heart failure
Authors: Wong Lee Lee , Rademaker Miriam T. , Saw Eng Leng , Lew Kar Sheng , Ellmers Leigh J. , Charles Christopher J. , Richards Arthur Mark , Wang Peipei 
Published: August 2017

AbstractStudy of microRNA (miRNAs) using sheep models is limited due to lack of miRNA information. We therefore investigated oar-miRNAs and their regulation in an ovine model of heart failure (HF). Left ventricular (LV) tissue was collected from normal (Cont), HF (LV pacing @ ~220bpm for 13-days) and HF-recovery sheep (HF-R, 26-days after pacing cessation). MiRNA expression was profiled using next-generation sequencing (NGS) and miRNA array, and validated by stem-loop qPCR. Detected sequences were mapped against the ovine genome (Oar v4.0) and aligned with known miRNAs (miRBase v21). A total of 36,438,340 raw reads were obtained with a peak distribution of 18–23 nt. Of these, 637 miRNAs were detected by NGS and mapped to the ovine genome. With cut-off at 10 counts, 275 novel miRNAs were identified (with 186 showing 100% alignment and 89 showing 70–99% alignment with human/mouse and/or rat miRNAs, respectively), and 78 known oar-miRNAs. Cardiac-enriched miRNA-1, -133a, -208a/b and -499 were highly expressed in the LV. With HF induction, miRNA-133b-3p, -208b-3p, -125a-5p, -125b-5p, -126-3p, -21-5p, -210-3p, -29a-3p, -320a and -494-3p were significantly up-regulated relative to Cont and tended to return to normal levels following HF-recovery. This study has expanded the sheep miRNA database, and demonstrated HF-induced regulation of miRNAs.
Cross-modal plasticity in the deaf enhances processing of masked stimuli in the visual modality
Authors: Prasad Seema , Patil Gouri Shanker , Mishra Ramesh Kumar 
Published: August 2017

AbstractCompensatory changes as a result of auditory deprivation in the deaf lead to higher visual processing skills. In two experiments, we explored if such brain plasticity in the deaf modulates processing of masked stimuli in the visual modality. Deaf and normal-hearing participants responded to targets either voluntarily or by instruction. Masked primes related to the response were presented briefly before the targets at the center and the periphery. In Experiment 1, targets appeared only at the foveal region whereas, in Experiment 2, they appeared both at the fovea and the periphery. The deaf showed higher sensitivity to masked primes in both the experiments. They chose the primed response more often and also were faster during congruent responses compared to the normal hearing. These results suggest that neuroplasticity in the deaf modulates how they perceive and use information with reduced visibility for action selection and execution.
The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
Authors: Puškárová Andrea , Bučková Mária , Kraková Lucia , Pangallo Domenico , Kozics Katarína 
Published: August 2017

AbstractSix essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. Antimicrobial activity was shown against pathogenic (Escherichia coli, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis) and environmental bacteria (Bacillus cereus, Arthrobacter protophormiae, Pseudomonas fragi) and fungi (Chaetomium globosum, Penicillium chrysogenum, Cladosporium cladosporoides, Alternaria alternata, and Aspergillus fumigatus). Oregano, thyme, clove and arborvitae showed very strong antibacterial activity against all tested strains at both full strength and reduced concentrations. These essential oils showed different fungistatic and fungicidal activities when tested by direct application and in the vapor phase. The genotoxic effects of these oils on HEL 12469 human embryo lung cells were evaluated using an alkaline comet assay for the first time, revealing that none of the oils induced significant DNA damage in vitro after 24 h. This study provides novel approaches for assessing the antimicrobial potential of essential oils in both direct contact and the vapor phase and also demonstrates the valuable properties of the phenol-free arborvitae oil. These results suggest that all the tested essential oils might be used as broad-spectrum anti-microbial agents for decontaminating an indoor environment.
Improving a genetically encoded voltage indicator by modifying the cytoplasmic charge composition
Authors: Lee Sungmoo , Geiller Tristan , Jung Arong , Nakajima Ryuichi , Song Yoon-Kyu , Baker Bradley J. 
Published: August 2017

AbstractAn improved genetically encoded voltage indicator (GEVI) was achieved by altering the charge composition of the region linking the voltage-sensing domain of the GEVI to a pH-sensitive fluorescent protein. Negatively charged linker segments reduced the voltage-dependent optical signal while positively charged linkers increased the signal size. Arginine scanning mutagenesis of the linker region improved the signal size of the GEVI, Bongwoori, yielding fluorescent signals as high as 20% ΔF/F during the firing of action potentials. The speed of this new sensor was also capable of optically resolving action potentials firing at 65 Hz. This large signal size enabled individual pixels to become surrogate electrodes. Plotting the highest correlated pixels based only on fluorescence changes reproduced the image of the neuron exhibiting activity. Furthermore, the use of a pH-sensitive fluorescent protein facilitated the detection of the acidification of the neuron during the firing of action potentials.
Structural analysis of Wss1 protein from saccharomyces cerevisiae
Authors: Yang Xiaoyun , Li Yanhua , Gao Zengqiang , Li Zongqiang , Xu Jianhua , Wang Wenjia , Dong Yuhui 
Published: August 2017

AbstractWss1 is a DNA-protein crosslinks (DPCs) repair protein, which is responsible for degradation of the protein components in DPCs. In this investigation, crystal structure of the protease domain from saccharomyces cerevisiae Wss1 (ScWss1) was solved and was compared with the known crystal structure of Schizosaccharomyces prombe Wss1 (SpWss1). It is found that the cleft near zinc ion to be the most conserved core region of Wss1 and that the electronic surface distributions vary greatly between the two homologs. Solution architecture of the full-length ScWss1 was further investigated by small-angle X-ray scattering (SAXS), which indicated the protein contains a flexible region inside. Finally, based on the structural information, a mechanism was proposed about how the enzyme is activated by DNA substrates.
An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration
Authors: Kim Martha , Park Joo-Hee , Jeong Hyejoong , Hong Jinkee , Choi Woo Sung , Lee Byung-Han , Park Choul Yong 
Published: August 2017

AbstractNonporous silica nanoparticles (SiNPs) have potential as promising carriers for ophthalmic drugs. However, the in vivo safety of ocular topical SiNPs remains unclear. This study investigated the in vivo safety of oral and ocular topical applications of 100 nm-sized SiNPs in Sprague-Dawley rats. The rats were divided into the following four groups: low-dose oral administration (total 100 mg/kg of SiNPs mixed with food for one week), high-dose oral administration (total 1000 mg/kg of SiNPs mixed with food for one week), ocular topical administration (10 mg/ml concentration, one drop, applied to the right eyes four times a day for one month), or a negative control (no SiNP treatment). The rats were observed for 12 weeks to investigate any signs of general or ocular toxicity. During the observation period, no differences were observed in the body weights, food and water intakes, behaviors and abnormal symptoms of the four groups. No animal deaths occurred. After 12 weeks, hematologic, blood biochemical parameters and ophthalmic examinations revealed no abnormal findings in any of the animals. The lack of toxicity of the SiNPs was further verified in autopsy findings of brain, liver, lung, spleen, heart, kidneys, intestine, eyeballs, and ovaries or testes.
Identification of potential impacts of climate change and anthropogenic activities on streamflow alterations in the Tarim River Basin, China
Authors: Xue Lianqing , Yang Fan , Yang Changbing , Chen Xinfang , Zhang Luochen , Chi Yixia , Yang Guang 
Published: August 2017

AbstractUnderstanding contributions of climate change and human activities to changes in streamflow is important for sustainable management of water resources in an arid area. This study presents quantitative analysis of climatic and anthropogenic factors to streamflow alteration in the Tarim River Basin (TRB) using the double mass curve method (DMC) and the Budyko methods. The time series (1960~2015) are divided into three periods: the prior impacted period (1960~1972) and the two post impacted periods, 1973~1986 and 1987~2015 with trend analysis. Our results suggest that human activities played a dominant role in deduction in the streamflow in TRB with contribution of 144.6% to 120.68% during the post impacted period I and 228.68% to 140.38% during the post impacted period II. Climatic variables accounted for 20.68%~44.6% of the decrease during the post impacted period I and 40.38% ~128.68% during the post impacted period II. Sensitivity analysis indicates that the streamflow alteration was most sensitive to changes in landscape parameters. The aridity index and all the elasticities showed an obvious increasing trend from the upstream to the downstream in the TRB. Our study suggests that it is important to take effective measures for sustainable development of eco-hydrological and socio-economic systems in the TRB.
Heart Failure and Total Hip Arthroplasty: What Are the Perioperative Outcomes and Complications?
Authors: Curtis Gannon , George Jaiben , Newman Jared , Barsoum Wael , Higuera Carlos , Klika Alison 
Published: August 2017

AbstractHeart failure (HF) has been reported to cause morbidity and mortality after surgery. As the prevalence of HF and hip osteoarthritis increase, physicians are likely to observe a rise in the number of HF patients requiring total hip arthroplasty (THA). We asked (1) what perioperative outcomes can be expected for patients with HF after THA, and (2) does HF contribute to an increased risk of short-term complications after THA? The National Surgical Quality Improvement Program database was accessed to find patients with osteoarthritis who underwent THA from 2008 to 2014. The HF cohort included 177 patients, while the control group consisted of 64,619 patients. Demographics, comorbidities, outcomes, and complications were collected. Multivariate regression analysis was performed. HF patients were found to have longer hospital stays (β = 0.87; p = 0.004) and were less likely to be discharged home (OR = 1.77, p = 0.001) following THA. It also increased the risk for any complication (OR = 1.54, p = 0.011), mortality (OR = 3.67, p = 0.042), readmission (OR = 1.68, p = 0.041), cardiac arrest (OR = 8.44, p = 0.006), myocardial infarction (OR = 3.75, p = 0.014), and deep surgical site infection (OR = 3.62, p = 0.035). HF patients had longer hospital stays and were discharged to a facility after THA. Overall, they had an increased risk of any complication, readmission, cardiac arrest, myocardial infarction, and deep surgical site infection. Moreover, the mortality risk after THA was significantly high. Cardiac optimization could play a key role in the prevention of these adverse outcomes. Patients should be counseled prior to surgery.
Demenz und Ethik – Personen mit Demenz im Akutkrankenhaus
Authors: Heil Joachim 
Published: August 2017

Zusammenfassung
Der Mensch mit Demenz bleibt Person Soll der Umgang mit Menschen mit Demenz menschenwürdig sein, müssen wir diese als Personen
wahrnehmen und dürfen sie nicht aus dem „Club der Personen“ ausschließen. Wir müssen uns über unsere eigenen Ängste und Formen der Abwehr
hinausbewegen.
Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory
Authors: Atucha Erika , Vukojevic Vanja , Fornari Raquel V. , Ronzoni Giacomo , Demougin Philippe , Peter Fabian , Atsak Piray , Coolen Marcel W. , Papassotiropoulos Andreas , McGaugh James L. , de Quervain Dominique J.-F. , Roozendaal Benno 
Published: August 2017

SignificanceEmotional arousal creates lasting and vivid memories. According to the systems consolidation theory, the hippocampus has a time-limited role in memory, and retrieval of remote memories mainly relies on neocortical networks. Here we show that this systems consolidation and associated change in memory specificity constitute a dynamically regulated process that can be modified by emotional arousal status. Norepinephrine administration into the basolateral amygdala after an episodic-like training experience maintained accuracy and hippocampus dependency of remote memory. This altered systems consolidation was paralleled by time-regulated epigenetically driven transcriptional changes of memory-related genes in the hippocampus and neocortex.
Religious lexis and political ideology in English Civil War newsbooks
Authors: Cecconi Elisabetta 
Published: August 2017

Abstract
In this article I provide a corpus-assisted discourse analysis of two influential English Civil War newsbooks which dominated the arena of seventeenth-century adversarial journalism: the royalist Mercurius Aulicus and the parliamentarian Mercurius Britanicus. Given the major role played by religion in the outbreak of the Civil War, my paper focuses on religious words and examines their collocational behavior in concordances and larger stretches of discourse. The analysis highlights the discourse strategies adopted by the two editors in order to frame, confirm and legitimate opposite versions of the news events and construe ideological consensus in their readership. In a period of intense experimentation in news rhetoric and political propaganda, this corpus-based investigation documents the development of a strongly factious news style for a growing, politically biased readership.
Contemporary observations on the attention value and selling power of English print advertisements (1700–1760)
Authors: Brownlees Nicholas 
Published: August 2017

Abstract
One of the most distinctive features of the early eighteenth-century English press was the substantial increase in advertisements. This increase in advertising did not go unnoticed by the leading writers of the day. Addison, Steele, Fielding and Johnson all comment on advertising discourse and its typographical presentation. This contribution analyses these contemporaries’ views within a theoretical framework that Leech (1966) and Gotti (2005) propose in relation to the communicative features and language of advertising discourse. Two of these characteristics are Attention Value and Selling Power. The analysis of eighteenth-century advertising is supported by reference to contemporary advertisements in the Newcastle Courant.
A modest proposal in The Gentleman’s Magazine
Authors: Sklar Howard , Taavitsainen Irma 
Published: August 2017

Abstract

The Gentleman’s Magazine (GM, 1732–1922) was the first periodical magazine targeted at an educated lay readership from polite society. Medical items and related issues were a regular feature, e.g. suicide was a recurring topic in its early years. One example of this was a 1755 mock advertisement advocating a discreet “remedy against life” suitable to “any nobleman, gentleman, or other man of wit, humour, and pleasure”. We approach our task from the point of view of historical pragmatics paying attention to the sociocultural context, and providing a rhetorical analysis to make sense of this peculiar advertisement. The ad seems to build on the dark side of a recently-deceased (1751), notorious Tory politician, who had been a central figure of polite society for decades, but the actual target of the satire must have been something else. We argue that the sociohistorical context with its shared knowledge, as well as the rhetorical structure and stylistic content of the ad itself, provide keys for making sense of the text.
Diffusing political knowledge in illustrated magazines
Authors: Sousa Jorge Pedro , Freitas Elsa Simões Lucas , Tuna Sandra Gonçalves 
Published: August 2017

Abstract
It is our purpose to compare two illustrated periodicals (a Portuguese and a British one) during the 1837–1844 period as to the way political issues are addressed and conveyed, as well as to ascertain the underlying cultural and social reasons in the two countries that can explain the approximations and divergences detected. The Portuguese O Panorama (1837–1868) diffused cultural matters in general. It was created by the Sociedade Propagadora dos Conhecimentos Úteis under the patronage of Alexandre Herculano, a famous man of letters, journalist and writer. The first three series of O Panorama are a direct imitation of the British The Penny Magazine (1832–1845), created by Charles Knight, under the auspices of the Society for the Diffusion of Useful Knowledge.
Narrative vs. “objective” style
Authors: Stenvall Maija 
Published: August 2017

Abstract
The paper examines stylistic changes in newspaper articles on violence between 1859 and 1910. I have looked both at news narratives, and at signs of the new, “objective” writing style. Whenever possible, I have chosen stories attributed to AP (the Associated Press) and Reuters news agencies, since as global distributors of news, they have had an influential role in creating and reinforcing conventions of news writing. The paper clearly demonstrates the difference between the ghastly, chronological murder stories of the late nineteenth century and the “modern” style adopted in the AP Siedlce narrative in 1906. The first evidence of the intentionally “objective” writing style I found in Reuters telegrams on the Siedlce pogrom in 1906.