bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermoluminescent and Monte Carlo dosimetry of IR06‐ brachytherapy source
Authors: Saidi Pooneh , Sadeghi Mahdi , Hosseini S. Hamed , Tenreiro Claudio 
Published: February 2017

This work presents experimental dosimetry results for a new brachytherapy seed, in accordance with the AAPM TG‐43U1 recommendation that all new low‐energy interstitial brachytherapy seeds should undergo one Monte Carlo (MC) and at least one experimental dosimetry characterization. Measurements were performed using TLD‐GR200A circular chip dosimeters using standard methods employing thermoluminescent dosimeters in a Perspex phantom. The Monte Carlo N‐particle (MCNP) code, version 5 was used to evaluate the dose‐rate distributions around this model source in water and Perspex phantoms. The consensus value for dose‐rate constant of the IR06‐ source was found equal to . The anisotropy function, , and the radial dose function, , of the seed were measured in Perspex phantom and calculated in both Perspex and liquid water phantom. The measured values were also found in good agreement with corresponding MC calculations.PACS number: 87.53.Jw
Dose to craniofacial region through portal imaging of pediatric brain tumors
Authors: Hitchen Christine J. , Osa Etin‐Osa , Dewyngaert J. Keith , Chang Jenghwa , Narayana Ashwatha 
Published: February 2017

The purpose of this study was to determine dose to the planning target volume (PTV) and organs at risk (OARs) from portal imaging (PI) of the craniofacial region in pediatric brain tumor patients treated with intensity‐modulated radiation therapy (IMRT). Twenty pediatric brain tumor patients were retrospectively studied. Each received portal imaging of treatment fields and orthogonal setup fields in the craniofacial region. The number of PI and monitor units used for PI were documented for each patient. Dose distributions and dose‐volume histograms were generated to quantify the maximum, minimum, and mean dose to the PTV, and the mean dose to OARs through PI acquisition. The doses resulting from PI are reported as percentage of prescribed dose. The average maximum, minimum, and mean doses to PTV from PI were , , and , respectively. The mean dose to the OARs from PI were brainstem , optic nerves/chiasm , cochlea , hypothalamus/pituitary , temporal lobes , thyroid , and eyes . The mean number of portal images and the mean number of PI monitor units per patient were 58.8 and 173.3, respectively. The dose from PI while treating pediatric brain tumors using IMRT is significant (2%–3% of the prescribed dose). This may result in exceeding the tolerance limit of many critical structures and lead to unwanted late complications and secondary malignancies. Dose contributions from PI should be considered in the final documented dose. Attempts must be made in PI practices to lower the imaging dose when feasible.PACS numbers: 87.55ne, 87.55Qr
Image intensifier distortion correction for fluoroscopic RSA: the need for independent accuracy assessment
Authors: Kedgley Angela E. , Fox Anne‐Marie V. , Jenkyn Thomas R. 
Published: February 2017

Fluoroscopic images suffer from multiple modes of image distortion. Therefore, the purpose of this study was to compare the effects of correction using a range of two‐dimensional polynomials and a global approach. The primary measure of interest was the average error in the distances between four beads of an accuracy phantom, as measured using RSA. Secondary measures of interest were the root mean squared errors of the fit of the chosen polynomial to the grid of beads used for correction, and the errors in the corrected distances between the points of the grid in a second position. Based upon the two‐dimensional measures, a polynomial of order three in the axis of correction and two in the perpendicular axis was preferred. However, based upon the RSA reconstruction, a polynomial of order three in the axis of correction and one in the perpendicular axis was preferred. The use of a calibration frame for these three‐dimensional applications most likely tempers the effects of distortion. This study suggests that distortion correction should be validated for each of its applications with an independent “gold standard” phantom.PACS numbers: 87.59.C, 87.57.cp, 87.57.nf
Sensitivity analysis of an asymmetric Monte Carlo beam model of a Siemens PRIMUS accelerator
Authors: Schreiber Eric C. , Sawkey Daren L. , Faddegon Bruce A. 
Published: February 2017

The assumption of cylindrical symmetry in radiotherapy accelerator models can pose a challenge for precise Monte Carlo modeling. This assumption makes it difficult to account for measured asymmetries in clinical dose distributions. We have performed a sensitivity study examining the effect of varying symmetric and asymmetric beam and geometric parameters of a Monte Carlo model for a Siemens PRIMUS accelerator. The accelerator and dose output were simulated using modified versions of BEAMnrc and DOSXYZnrc that allow lateral offsets of accelerator components and lateral and angular offsets for the incident electron beam. Dose distributions were studied for fields. The resulting dose distributions were analyzed for changes in flatness, symmetry, and off‐axis ratio (OAR). The electron beam parameters having the greatest effect on the resulting dose distributions were found to be electron energy and angle of incidence, as high as 5% for a 0.25° deflection. Electron spot size and lateral offset of the electron beam were found to have a smaller impact. Variations in photon target thickness were found to have a small effect. Small lateral offsets of the flattening filter caused significant variation to the OAR. In general, the greatest sensitivity to accelerator parameters could be observed for higher energies and off‐axis ratios closer to the central axis. Lateral and angular offsets of beam and accelerator components have strong effects on dose distributions, and should be included in any high‐accuracy beam model.PACS numbers: 87.55.K‐, 87.55.Gh
Modified dose difference method for comparing dose distributions
Authors: Bak Jino , Choi Jin Hwa , Kim Jae‐Sung , Park Suk Won 
Published: February 2017

The quantitative comparison of two‐dimensional dose distributions (e.g., calculated versus measured) has become a key issue in intensity‐modulated radiotherapy (IMRT) QA. We proposed a new evaluation method referred to as modified dose difference (MDdiff) evaluation. Hereinafter, features and effectiveness of the MDdiff evaluation method will be described. In this work, the formalism of MDdiff was defined by introducing a dimensionless parameter . A new formalism is compared to a gamma method, and the MDdiff and the gamma method are respectively applied to patient‐specific IMRT QA. The calculation of the evaluation of dose distributions was performed using a program. Evaluations were performed by counting the number of data points satisfying . The evaluation result of dose distributions using the MDdiff method had the same tendency as the evaluation result using the gamma evaluation method. The modified dose difference tool also provides a quantitative method for comparing two dose distributions like the gamma evaluation. Furthermore, many problems of gamma evaluation are resolved.PACS numbers: 87.55.km, 87.55.Qr
Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
Authors: Joy Sarah , Starkschall George , Kry Stephen , Salehpour Mohammed , White R. Allen , Lin Steven H. , Balter Peter 
Published: February 2017

The purpose of this work was to determine the dosimetric benefit to normal tissues by tracking the multi‐leaf collimator (MLC) apertures with the photon jaws in step‐and‐shoot intensity‐modulated radiation therapy (IMRT) on the Varian 2100 platform. Radiation treatment plans for ten thoracic, three pediatric, and three head and neck cancer patients were converted to plans with the jaws tracking each segment's MLC apertures, and compared to the original plans in a commercial radiation treatment planning system (TPS). The change in normal tissue dose was evaluated in the new plan by using the parameters V5, V10, and V20 (volumes receiving 5, 10 and 20 Gy, respectively) in the cumulative dose‐volume histogram for the following structures: total lung minus gross target volume, heart, esophagus, spinal cord, liver, parotids, and brainstem. To validate the accuracy of our beam model, MLC transmission was measured and compared to that predicted by the TPS. The greatest changes between the original and new plans occurred at lower dose levels. In all patients, the reduction in V20 was never more than 6.3% and was typically less than 1%; the maximum reduction in V5 was 16.7% and was typically less than 3%. The variation in normal tissue dose reduction was not predictable, and we found no clear parameters that indicated which patients would benefit most from jaw tracking. Our TPS model of MLC transmission agreed with measurements with absolute transmission differences of less than 0.1% and, thus, uncertainties in the model did not contribute significantly to the uncertainty in the dose determination. We conclude that the amount of dose reduction achieved by collimating the jaws around each MLC aperture in step‐and‐shoot IMRT is probably not clinically significant.PACS numbers: 87.55.D‐ 87.55.de 87.55.dk
Target repositional accuracy and PTV margin verification using three‐dimensional cone‐beam computed tomography (CBCT) in stereotactic body radiotherapy (SBRT) of lung cancers
Authors: Wang Lu , Feigenberg Steven , Fan Jiajin , Jin Lihui , Turaka Aruna , Chen Lili , Ma C‐M Charlie 
Published: February 2017

The purpose of this study was to assess target repositional accuracy with respect to the bony structures using daily CBCT, and to validate the planning target volume (PTV) margin used in the lung SBRT. All patients underwent 4D CT scanning in preparation for lung SBRT. The internal target volume (ITV) was outlined from the reconstructed 4D data using the maximum‐intensity projection (MIP) algorithm. A 6 mm margin was added to the ITV to create the PTV. Conformal treatment planning was performed on the helical images, to which the MIP images were fused. Prior to each treatment, CBCT was taken after a patient was set up in the treatment position. The CBCT images were fused with the simulation CT based on the bony anatomy, in order to derive setup errors and separate them from the tumor repositional errors. The treating physician then checked and modified the alignment based on target relocalization within the PTV. The shifts determined in such a method were recorded and the subtractions of these shifts with respect to the corresponding setup errors were defined as the target relocalization accuracy. Our study of 36 consecutive patients, treating 38 targets for a total of 153 fractions shows that, after setup error correction, the target repositional accuracy followed a normal distribution with the mean values close to 0 in all directions, and standard deviations of 0.25 cm in A–P, 0.24 cm in Lat, and 0.28 cm in S–I directions, respectively. The probability of having the shifts is less than 0.8% in A–P, 0.6% in Lat, and 1.7 % in S‐I directions. For the patient population studied, the target centroid position relative to the bony structures changed minimally from day to day. This demonstrated that the PTV margin that is designed on the MIP image‐based ITV was adequate for lung SBRT.PACS number: 87.53.Ly
VMAT testing for an Elekta accelerator
Authors: Kaurin Darryl G.L. , Sweeney Larry E. , Marshall Edward I. , Mahendra Saikanth 
Published: February 2017

Volumetric‐modulated arc therapy (VMAT) has been shown to be able to deliver plans equivalent to intensity‐modulated radiation therapy (IMRT) in a fraction of the treatment time. This improvement is important for patient immobilization/ localization compliance due to comfort and treatment duration, as well as patient throughput. Previous authors have suggested commissioning methods for this modality. Here, we extend the methods reported for the Varian RapidArc system (which tested individual system components) to the Elekta linear accelerator, using custom files built using the Elekta iComCAT software. We also extend the method reported for VMAT commissioning of the Elekta accelerator by verifying maximum values of parameters (gantry speed, multileaf collimator (MLC) speed, and backup jaw speed), investigating: 1) beam profiles as a function of dose rate during an arc, 2) over/under dosing due to MLC reversals, and 3) over/under dosing at changing dose rate junctions. Equations for construction of the iComCAT files are given. Results indicate that the beam profile for lower dose rates varies less than 3% from that of the maximum dose rate, with no difference during an arc. The gantry, MLC, and backup jaw maximum speed are internally consistent. The monitor unit chamber is stable over the MUs and gantry movement conditions expected. MLC movement and position during VMAT delivery are within IMRT tolerances. Dose rate, gantry speed, and MLC speed are accurately controlled. Over/under dosing at junctions of MLC reversals or dose rate changes are within clinical acceptability.PACS numbers: 87.55.de, 87.55.Qr, 87.56.bd
Assessment of an organ‐based tube current modulation in thoracic computed tomography
Authors: Matsubara Kosuke , Sugai Mai , Toyoda Asami , Koshida Haruka , Sakuta Keita , Takata Tadanori , Koshida Kichiro , Iida Hiroji , Matsui Osamu 
Published: February 2017

Recently, specific computed tomography (CT) scanners have been equipped with organ‐based tube current modulation (TCM) technology. It is possible that organ‐based TCM will replace the conventional dose‐reduction technique of reducing the effective milliampere‐second. The aim of this study was to determine if organ‐based TCM could reduce radiation exposure to the breasts without compromising the image uniformity and beam hardening effect in thoracic CT examinations. Breast and skin radiation doses and the absorbed radiation dose distribution within a single section were measured with an anthropomorphic phantom and radiophotoluminescent glass dosimeters using four approaches to thoracic CT (reference, organ‐based TCM, copper shielding, and the combination of the above two techniques, hereafter referred to as the combination technique). The CT value and noise level were measured using the same calibration phantom. Organ‐based TCM and copper shielding reduced radiation doses to the breast by 23.7% and 21.8%, respectively. However, the CT value increased, especially in the anterior region, using copper shielding. In contrast, the CT value and noise level barely increased using organ‐based TCM. The combination technique reduced the radiation dose to the breast by 38.2%, but greatly increased the absorbed radiation dose from the central to the posterior regions. Moreover, the CT value increased in the anterior region and the noise level increased by more than 10% in the entire region. Therefore, organ‐based TCM can reduce radiation doses to breasts with only small increases in noise levels, making it preferable for specific groups of patients, such as children and young women.PACS numbers: 87.53.Bn; 87.57.Q‐; 87.57.qp
Safety limitations of MR‐HIFU treatment near interfaces: a phantom validation
Authors: Hipp Elizabeth , Partanen Ari , Karczmar Gregory S. , Fan Xiaobing 
Published: February 2017

Magnetic resonance‐guided high‐intensity focused ultrasound (MR‐HIFU) is a noninvasive image‐guided technique used to thermally ablate solid tumors. During treatment, ultrasound reflections from distal media interfaces can shift prescribed treatment locations. The purpose of this study was to investigate the effect of normal incidence reflections from air, acrylic (modeling bone), and rubber on treatment location, temperature elevation, and heating patterns by performing ultrasound exposures in a tissue‐mimicking phantom and in ex vivo porcine tissue using a clinical MR‐HIFU platform. The results demonstrated a shift in treatment location toward the distal interface when targeted closer than 2 cm from the interface, especially for acrylic. Our study demonstrated that the ultrasound wave reflections from a distal air interface had less effect than the acrylic interface (modeling bone) on the heating pattern and focal location. This study provides useful information to better understand the limitations and safety concerns of performing MR‐HIFU treatments with commercial clinical equipment.PACS numbers: 87.61.‐c, 87.63.D
In vivo dose measurement using TLDs and MOSFET dosimeters for cardiac radiosurgery
Authors: Gardner Edward A. , Sumanaweera Thilaka S. , Blanck Oliver , Iwamura Alyson K. , Steel James P. , Dieterich Sonja , Maguire Patrick 
Published: February 2017

In vivo measurements were made of the dose delivered to animal models in an effort to develop a method for treating cardiac arrhythmia using radiation. This treatment would replace RF energy (currently used to create cardiac scar) with ionizing radiation. In the current study, the pulmonary vein ostia of animal models were irradiated with 6 MV X‐rays in order to produce a scar that would block aberrant signals characteristic of atrial fibrillation. The CyberKnife radiosurgery system was used to deliver planned treatments of 20–35 Gy in a single fraction to four animals. The Synchrony system was used to track respiratory motion of the heart, while the contractile motion of the heart was untracked. The dose was measured on the epicardial surface near the right pulmonary vein and on the esophagus using surgically implanted TLD dosimeters, or in the coronary sinus using a MOSFET dosimeter placed using a catheter. The doses measured on the epicardium with TLDs averaged 5% less than predicted for those locations, while doses measured in the coronary sinus with the MOSFET sensor nearest the target averaged 6% less than the predicted dose. The measurements on the esophagus averaged 25% less than predicted. These results provide an indication of the accuracy with which the treatment planning methods accounted for the motion of the target, with its respiratory and cardiac components. This is the first report on the accuracy of CyberKnife dose delivery to cardiac targets.PACS numbers: 87.53.Ly, 87.53.Bn
Total body irradiation dose optimization based on radiological depth
Authors: Hussain Amjad , Dunscombe Peter , Villarreal‐Barajas J. Eduardo , Brown Derek 
Published: February 2017

We have previously demonstrated the use of Eclipse fluence optimization to define aperture sizes for a novel aperture modulated translating bed total body irradiation (TBI) technique. The purposes of the present study were to identify, characterize, and correct for sources of error inherent in our previous fluence optimization technique, and to develop a clinically viable fluence optimization module for the translating bed TBI technique. Aperture modulated TBI is delivered by translating the patient at constant speed on a custom bed under a modulated radiation beam. The patient is then turned from supine to prone and the process repeated, resulting in an AP‐PA treatment. Radiological depths were calculated along divergent ray lines through individual CT slices of a RANDO phantom. Beam apertures, defined using a dynamic multileaf collimator (DMLC), were generated using calculated radiological depths and calibration factors that relate fluence to aperture size in a dynamic environment. These apertures were defined every 9 mm along the phantom superior‐inferior axis. The calculated beam apertures were further modified to account for scatter within the patient. For dose calculation purposes the individual MLC files were imported into Eclipse. For treatment delivery, dynamic MLC files for both AP and PA beams were generated and delivered dynamically. Dose homogeneity in the head and neck region of the RANDO phantom was within of the prescribed dose with this novel technique compared to to with our previous aperture modulated technique based on Eclipse fluence optimization. Fluence optimization and beam aperture calculation using the new technique offers a ten‐fold reduction in planning time and significantly reduces the likelihood of user error during the planning process. In conclusion, a clinically viable aperture modulated translating bed TBI technique that employs dynamically shaped MLC‐defined beam apertures based on radiological depth calculations, has been developed.PACS numbers: 87.55.‐x, 87.55.D‐
An evaluation of the Clarity 3D ultrasound system for prostate localization
Authors: Robinson Don , Liu Derek , Steciw Stephen , Field Colin , Daly Helene , Saibishkumar Elantholi P. , Fallone Gino , Parliament Matthew , Amanie John 
Published: February 2017

The purpose of this study is to evaluate the accuracy and precision of the Clarity 3D ultrasound system to track prostate gland positional variations due to setup error and organ motion. Seventeen patients () undergoing radical external beam radiation therapy for localized prostate cancer were studied. Subsequent to initial reference ultrasound and planning CT scans, each patient underwent seven repeat weekly tracking CT and ultrasound (US) scans during the course of treatment. Variations in the location of the prostate between reference and tracking scans were measured. Differences reported by CT and ultrasound scans are compared. Ultrasound tracking was initially performed clinically by a group of trained general users. Retrospective prostate localization was then performed by a trained dedicated user upon the original raw data set and also a reduced data set derived from the original by an expert user from Resonant Medical. Correlation accuracy between ultrasound and CT shifts acquired and delineated by a pool of trained general users was deemed unacceptable for radiotherapy purposes. A mean discrepancy between CT and US localizations of greater than 10 mm, with a 5 mm or greater discrepancy rate of nearly 90%, was observed. Retrospective analysis by a dedicated user of both the original and Resonant Medical reduced data sets yielded mean CT‐Us discrepancies of 8.7 mm and 7.4 mm, respectively. Unfortunately, the 5 mm or greater CT‐US discord rate for these retrospective analyses failed to drop below 80%. The greatest disparity between CT and ultrasound was consistently observed in the superior–inferior direction, while greatest agreement was achieved in the lateral dimension. Despite an expert reanalysis of the original data, the Clarity ultrasound system failed to deliver an acceptable level of geometric accuracy required for modern radiotherapy purposes.PACS numbers: 8755ne, 87.56Da, 87.63dh
Magnetic resonance thermal imaging combined with SMASH navigators in the presence of motion
Authors: Seo Youngseob , Willig‐Onwuachi Jacob , Walton Jeffrey H. 
Published: February 2017

This study develops and tests an MR thermometry method combined with SMASH navigators in phantom experiments mimicking human liver motion with the purpose of detecting and correcting motion artifacts in thermal MR images. Experimental data were acquired on a 3T MRI scanner. Motion artifacts of mobile phantoms mimicking human liver motion were detected and corrected using the SMASH navigators and then MR temperature maps were obtained using a proton resonant frequency (PRF) shift method with complex image subtraction. Temperature acquired by MR thermal imaging was compared to that measured via thermocouples. MR thermal imaging combined with the SMASH navigator technique resulted in accurate temperature maps of the mobile phantoms compared to temperatures measured using the thermocouples. The differences between the obtained and measured temperatures varied from 8.2°C to 14.2°C and 2.2°C to 4.9°C without and with motion correction, respectively. Motion correction improved the temperature acquired by MR thermal imaging by . The combination of the MR thermal imaging and SMASH navigator technique will enable monitoring and controlling heat distribution and temperature change in tissues during thermal therapies and will be a very important tool for cancer treatment in mobile organs.PACS number: 87.57.‐s