bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Portuguese Validation of the Impulsive Sensation Seeking Scale
Authors: Dourado J.F. , Marques C. , Pereira A.T. , Nogueira V. , Macedo A. , Silva A.M. Bastos , Seco A.J. 
Published: June 2017

IntroductionPersonality traits such as Impulsivity and Sensation seeking are associated with aggressive and/or risky driving behaviour. Understanding the influence of these traits in the driving task is important to perform a more comprehensive study of road trauma, which is an increasing public health and economic concern.ObjectiveTo study the reliability and the construct validity of the Portuguese version of impulsive sensation seeking scale (ImpSS) using exploratory and confirmatory factor analysis (EFA and CFA).Methods747 participants [417 (55.8%) women; mean age = 42.13 ± 12.349 years; mean driving license years = 21.30 ± 11.338; mean years of regular driving = 20.33 ± 11.328] answered an online survey which included this scale, and other socio-demographic information. Inclusion criteria were: driving license and regular driving for at least three years and age lower than 75 years old. The total sample was randomly divided in two sub-samples, with sample A (n = 373) being used to perform EFA, and sample B to perform CFA.ResultsThe most acceptable factor model for ImpSS scale was the two-factor model found with EFA, excluding items 4, 6, 7 and 10 (χ2/df = 2.13; TLI = .90; CFI = .92; RMSEA = .05, P = .211). The internal consistency analysis resulted in: Sensation seeking, α = .79; Impulsivity, α = .76; total ImpSS score, α = .82.ConclusionsThese findings suggest that the ImpSS Scale is a valid and reliable measure to assess those personality traits in the Portuguese drivers.Disclosure of interestThe authors have not supplied their declaration of competing interest.
F17464 a new antipsychotic with preferential D3 antagonist, 5-HT1A partial agonist properties. Neurochemical studies
Authors: Cosi C. , N’Guyen V. , Consul-Denjean N. , Auclair A. , Heusler P. , Martel J.C. , Leriche L. , Sokoloff P. , Gatti-McArthur S. 
Published: June 2017

F17464 is a new dopamine receptor antagonist that recently demonstrated antipsychotic activity in a proof of concept study in schizophrenic patients under acute exacerbation. The compound has a unique profile with high affinity for hD3 receptors (Ki = 0.17 nM) and lower affinity for hD2L (Ki = 12.1 nM) and hD2S (Ki = 6.5 nM). F17464 exhibits also high affinity for h5-HT1A receptors (Ki = 0.16 nM). F17464 is a hD3 antagonist (pKB = 9.13), hD2S very week partial agonist (pKB = 7.87, emax 8% of DA stimulated in ERK assay) and a 5-HT1A partial agonist (pEC50 = 7.99). F17464 exhibits consistent affinities for rat striatal D2 (Ki = 4.8 nM) and for rat hippocampal 5-HT1A receptors (Ki = 1.14 nM). Neurochemical studies show that F17464 ip (1 h post-dose) produces a significant dose–dependent increase in the levels of DOPAC and HVA in the frontal cortex, caudate-putamen and limbic forebrain and an increase in 3-MT levels in the latter two regions with no changes in total DA content. The effect is significant at the doses of 0.63–2.5 mg/kg ip (PK/PD data will be provided). This pattern of DA metabolite changes is similar to that described for several antipsychotic drugs in rodents and it is indicative of a cortical effect of F17464. F17464 has a very low cataleptogenic activity in rats and mice and does not induce serotoninergic signs typical of 5-HT1A. F17464 is therefore a novel a D3 preferential antipsychotic with a unique mechanism of action and receptor affinity profile and a consistent effect in neurochemistry studies in rodents.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Factors of premorbid period indicating the risk of medicated noncompliance in patients with schizophrenia
Authors: Dmitrieva E. , Kornetova E. 
Published: June 2017

BackgroundMethods of assessment of medicated compliance are based upon preceding experience of taking therapy and cannot be applied at the first admission.ObjectiveTo investigate premorbid characteristics in schizophrenic patients and reveal the factors indicating noncompliance.MethodsWe used medical record background, interview, Medical Compliance Prediction Scale for Psychiatry for evaluation of the level of compliance, program STATISTICA10 for identification of the average level of compliance in the subgroups of each factor by Kruskal–Wallis test and revealing those subgroups for each factor where the average level of compliance was statistically significantly lower (P < 0.05).ResultsWe examined 120 patients (status corresponded to the ICD-10 diagnostic criteria for schizophrenia, age–18 and older, duration of the disease–5 years and more, patients taking typical or atypical antipsychotics or combined therapy) according to factors of premorbid period such as gender, family history of mental disorders, personality traits, nurture in the family, education level, marital status; substance use, age at the onset of disease.ConclusionsLevel of compliance was lower in subgroups of men, patients having several relatives with mental disorders, patients having personality with predominance of irritable and impulsive traits, patients with neglect in parental families, patients with education level lower than high school and with education level higher than bachelor; patients not working or studying to onset of disease; patients who were divorced or widowed; patients living alone; patients using psychoactive substances; patients aged 21 years and older to the onset of disease.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Cognitive Enhancement in Young Healthy Subjects Using Non-invasive Brain Stimulation and Cognitive Training
Authors: Brem A.K. 
Published: June 2017

Transcranial electrical stimulation (tES) is being widely investigated to understand and modulate human brain function. The interest in using tES to enhance cognitive abilities not only in patient populations but also in healthy individuals has grown in recent years. Specifically in combination with cognitive training tES has shown success in enhancing cognition. However, to date, we still know little about the impact of interindividual differences on intervention outcomes. A variety of tES techniques and their effects in combination with cognitive training, interactive effects of tES with baseline cognitive abilities and neurophysiological traits will be presented and following ramifications with regards to the development of individualised stimulation protocols will be discussed.Disclosure of interestThe author has not supplied his declaration of competing interest.
Comorbidity of schizophrenia and social phobia
Authors: Vrbova K. , Prasko J. , Latalova K. , Kamaradova D. , Ociskova M. , Sedlackova Z. 
Published: June 2017

IntroductionThe most common comorbid disorder in schizophrenic patients is a social phobia. It is usually an unrecognized problem that may be associated with a high distortion in managing claims of life.ObjectivesThe aim of our study was to determine the extent to which comorbid social phobia affects the severity and course of schizophrenia.MethodsThe publications were identified in the database medline and web of science using the keywords “schizophrenia comorbidity” in combination with the terms “social phobia” or “social anxiety disorder”. Other relevant sources of information were obtained from the cited works by important articles.ResultsThe current state of research shows that the incidence of comorbid social phobia in psychotic disease states in the range from 11% to 36%. Social phobia in psychotic patients remains largely unrecognized. An untreated social phobia is associated with more severe psychotic symptoms, worse quality of life and lower self-esteem. It also increases the tendency to social isolation and overall worsens social adaptation. Patients with comorbid social phobia and schizophrenia have a higher amount of lifetime suicide attempts and often abuse alcohol or addictive substance.ConclusionsPatients who have both schizophrenia and social phobia have a lower quality of life, impaired functioning in life, a higher incidence of suicide attempts and increased risk of relapse of psychosis. It is, therefore, necessary that physicians treating the patients with schizophrenia had in mind the possibility of the presence of comorbid social phobia, and in the case of its occurrence, they also treat it.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Sexuality of Tunisian women with polycystic ovary syndrome
Authors: Halouani N. , Ellouze S. , Naoui R. , Aloulou J. , Amami O. 
Published: June 2017

IntroductionThe polycystic ovary syndrome (PCOS) is a heterogeneous disease with multiple facets. In a few decades, this syndrome has gone from a purely gynaecological domain to sexology one; PCOS is thus considered a systemic disease. However, the domain of sexuality continues to be neglected. The aim of our study was: assessing women's sexuality with PCOS by comparing them to a sample correlated with the age of control subjects. We performed a cross-sectional study of case-control, conducted between October and November 2015.Data was collected by oral questionnaire proposed to women whose anonymity was respected. To assess the sexuality we used the “female sexual function index” (FSFI) developed by Rosen et al.ResultsThe average BMI of the patients was 30.2 ± 6.3 kg/m2, with a range of 17.2 to 43.5 kg/m2. The average frequency of sexual intercourse per week was 1.6 ± 0.5 for patients and 2.1 ± 0.9 for the controls. The scores used in this study show that 90% of sexual dysfunction exists in women with PCOS For controls, a sexual dysfunction was found in 40% of cases.All aspects of sexuality were affected (desire, arousal, orgasm and satisfaction). The lowest scores were found in the following areas: arousal, lubrication and orgasm.ConclusionThe therapist during a consultation for a patient with PCOS should check her psychological state. Also, asking the patient about her sex life should be part of the monitoring of the disease.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Selincro use in a patient diagnosed with dependence to stimulants, alcohol abuse and hyper-sexuality
Authors: Ballesteros A. , Rosero Á.S. , Inchausti F. , Manrique E. , Sáiz H. , Carrión C. 
Published: June 2017

IntroductionHyper-sexuality is an increased sexual activity that causes stress the individual at social levels. There are studies that support the theory that neurophysiological abnormalities of individuals appear in this disorder and do not overlap with the alterations found in substance addictions. However, it is doubtful whether addiction to other substances can trigger behavior in the sexual sphere.ObjectiveTo report a case of abuse of alcohol as a trigger relapse in terms of sexual alterations in a patient diagnosed with alcohol abuse, stimulants dependence and hyper-sexuality.Case descriptionHere we report a married gentleman in the fourth decade of his life that presents behavior and sexual activity level compatible with a case of hyper-sexuality. After conducting motivational interviews with the psychologist to aim a sustained abstinence of amphetamines and a lack of alterations on the sexual sphere, the patient achieved clinical stability over several years. However, it is referred for psychiatric consultation as he presented recently abusive alcohol consumption associated with Speed. He relapsed in the sexual sphere by increasing sexual desire and impulsiveness. It was decided to prescribe oral nalmefene (1 tablet daily) for two months and then stop treatment regularly (taken PRN in case of high risk situations). As a result, he has had sustained remission for over 6 months.ConclusionAlthough, there are studies suggesting that neurobiological changes among the pathologies described are different, the treatment of alcohol abuse can be beneficial in other diseases such as hyper-sexuality as disinhibition associated with alcohol intoxication.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Perceptions of problem-drinker patients’ family members about their own hazardous-drinking behaviours in Chinese general hospitals
Authors: Tsai Y.F. , Lin C.C. , Yeh W.L. , Kao J.T. , Chen C.Y. 
Published: June 2017

BackgroundExcessive alcohol use has been associated with health, social and legal problems. Studies of alcohol-drinking problems have mainly focused on patients with alcohol-drinking problems and few studies have focused on their family members. The purpose of this study was to explore the perceptions of family members of problem-drinker patients about their own hazardous or harmful alcohol-drinking behaviours.MethodsIn this qualitative descriptive study, participants were recruited from three hospitals randomly selected from northern and central Taiwan (2:1). Hazardous-drinker patients and their family members were screened using the Chinese version AUDIT. AUDIT scores > 8 indicated harmful or hazardous drinkers. Data were collected in individual, audiotaped, in-depth interviews using an interview guide. Verbatim interview transcripts were analysed using ATLAS.ti, version WIN 7.0.ResultsThe sample of 35 family members with hazardous or harmful drinking behaviours perceived that their own alcohol-drinking behaviours were related to six major patterns: family habits, leisure activities with friends, work pressures, personal taste, a way to forget one's problems and to express happiness.ConclusionsWe recommend that programs to prevent harmful or hazardous drinking should emphasize understanding standard amounts of alcohol in alcoholic beverages, recommended amounts of alcohol consumption for males and females, knowledge about the long-term effects of excessive alcohol consumption; offer strategies to resist social pressure to drink; and build positive strategies for coping with stress.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Establishment of a comprehensive inpatient suicide prevention network: Taiwan experience and systemic review
Authors: Changchien T.C. , Yen Y.C. 
Published: June 2017

IntroductionThe complexity of inpatient suicide in a general hospital setting, whether medical or surgical, is not fully understood currently. It is a common sentinel event and an important problem of patient safety. However, its evidence is currently lacking. So, we present a healthcare system approach to enhance the effectiveness of inpatient suicide prevention in Taiwan.MethodsWe reviewed available evidence about inpatient suicide. Some risk factors were detected. And we tried to improve our inpatient suicide prevention program with healthcare failure mode and effect analysis (HFMEA), which is a prospective qualitative analysis for numerous medical errors. In this study, HFMEA was used to reduce the likelihood of failure of current clinical practices in preventing inpatient suicide.ResultsThe psychiatric consultation rate increased after a series of improvement program. Besides, establishment of an integrated electronic medical system and the improvement of environment and facility safety are our main strategies. The HFMEA indicated that empowering staff with continuing education and case management by a full-time social worker and clinical psychologist were also needed. Furthermore, this hospital-based integrated suicide prevention program was accredited with the symbol of national quality of Taiwan in 2014.ConclusionOur study provided systematic intervention to improve inpatient suicide prevention in a general hospital, and in Taiwan. The HFMEA is a useful tool to improve inpatient suicide prevention measures. We still need more information and evidence to promote the importance of inpatient suicide prevention.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Suicide by jumping at beachy head in East Sussex – The impact of a suicide prevention patrol scheme
Authors: Durgahee S. , Isaac M. , Anderson J. 
Published: June 2017

IntroductionSuicide is a major public health issue. It is the leading cause of death among younger adults in the UK. Suicide by jumping is an uncommon method. About 23 people die each year by jumping from the cliffs at beachy head, Sussex. The beachy head chaplaincy established a suicide-prevention patrol at beachy head in August 2004. To date there have been no studies evaluating the impact of a suicide patrol as a prevention strategy. This study aimed to assess the impact of this suicide-prevention patrol.MethodsData from local and national official statistics was gathered to examine the overall suicide numbers and rates of suicide by jumping vs. other methods. This included an in-depth scrutiny of coroners’ data and reports from the beachy head chaplaincy.A qualitative, phenomenological approach using in-depth interviews was used to evaluate the “lived experiences” of members of the suicide-prevention patrol.ResultsThe statistics reveal unexpected and at times, conflicting, results which will be offered for discussion.The thematic analysis of the interviews reveals insights into the motivations for volunteering; how a faith-based patrol works; the physical and psycho-social impact of the work; volunteers’ stories; the centrality of God within their work and motivation.For copyright reasons full details of the analyses cannot be made available before the conference.DiscussionWe welcome an interactive discussion of the results.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Psychological Interventions for Psychogenic Non-epileptic Seizures: A Meta-analysis
Authors: Carlson P. 
Published: June 2017

Introduction and objectivePsychological interventions for psychogenic non-epileptic seizures (PNES) show promising results. The aim of this meta-analysis is to evaluate and synthesize the available evidence from the previous 20 years regarding the utility of psychological interventions in the management of PNES.MethodStudies were retrieved from MEDLINE via OvidSP and PsychINFO. Selection criteria included controlled and before-after non-controlled studies including case series, using seizure frequency as an outcome measurement. Studies were required to assess one or more types of psychological intervention for the treatment of PNES in adults. Data from 13 eligible studies was pooled to examine the effectiveness of psychological interventions in treating PNES on two primary outcomes: seizure reduction of ≥ 50% and seizure freedom. A meta-analysis was conducted with data extracted from 228 participants with PNES.ResultsInterventions reviewed in the analysis included CBT, psychodynamic therapy, paradoxical intention therapy, mindfulness, psychoeducation and eclectic interventions. Meta-analysis synthesized data from 13 studies with a total of 228 participants with PNES, of varied gender and age. Results showed 82% of people with PNES who complete psychotherapy experience a reduction in seizures of ≥50%. Additional meta-analysis synthesized data from 10 studies with a total of 137 participants with PNES. This analysis found 47% of people with PNES are seizure free upon completion of a psychological intervention.ConclusionThe studies identified were diverse in nature and quality. Findings highlight the potential for psychological interventions as a favorable alternative to the current lack of treatment options offered to people with PNES.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Psychoemotional Disorders in Pregnancy with Hypertensive Complications
Authors: Gardanova Z. , Khritinin D. , Anisimova K. 
Published: June 2017

Psychoemotional disorders in pregnant women represent a significant medical and social problem as well as the effects caused by this pathology have a profound effect on children born to such mothers, as well as to themselves mothers during and after pregnancy. The goal–psychological correction of psycho-emotional states in pregnant women with hypertensive syndrome by Erickson hypnosis. The study was conducted on the basis of state organization “Research Center for Obstetrics, Gynecology and Perinatology named after Academician VI Kulakov”. The study involved 150 pregnant women with hypertensive syndrome. Seventy-five pregnant women with hypertensive syndrome received psychological correction method of Erickson hypnosis in an amount of 15 sessions. To assess the state of mental and emotional techniques used depression scale Beck Anxiety Scale, Spielberger-Hanin. The study was conducted 4 times–the first, second, and third trimesters of three months after childbirth. When comparing the psycho-emotional state of pregnant women with hypertensive syndrome on the background of psychological adjustment method Erickson hypnosis and in pregnant women with hypertensive syndrome who did not receive psychological correction revealed a statistically significant difference. In pregnant women with hypertensive syndrome who received psychological correction method of Erickson hypnosis, revealed lower levels of depression and situational anxiety than women who did not receive psychological correction. Thus, our study proved the need for psychological correction method of Erickson hypnosis and its effectiveness for stabilizing the psycho-emotional state of pregnant women with hypertensive syndrome and pre-eclampsia prevention.Disclosure of interestThe authors have not supplied their declaration of competing interest.
(Re)examining the Factorial sstructure of the Generalized Anxiety Disorder-7 in a College Students Sample
Authors: Monteiro S. , Bártolo A. , Torres A. , Pereira A. 
Published: June 2017

IntroductionGeneralized anxiety in young adults during college career is a serious public-health problem that untreated has a chronic course. Research has shown that the self-report questionnaire generalized anxiety disorder-7 (GAD-7) is a reliable and valid measure to assess generalized anxiety symptoms severity in heterogeneous psychiatric samples. However, GAD-7 is not available for non-clinical populations and their factor structure has not been re-examined.ObjectivesOur objective was to examine factor structure and measurement invariance of the GAD-7 among college students testing two alternatives models.AimsThe original model fit of single-factor was compared to two-factor model that considered in comprehensive approach of generalized anxiety the assessment of cognitive-emotional nature and somatic symptoms.MethodsIn this cross-sectional study the GAD-7 was administrated to college students (n = 1031) recruited in the six schools which compose the Polytechnic Institute of Coimbra, Portugal. Confirmatory factor analysis was used testing two models.ResultsAmong college students, 32.8% reported significant generalized anxiety symptoms. The original unidimensional structure of GAD-7 was confirmed but the two-factor model comprising cognitive–emotional and somatic factors presented better fit to the data (χ2(1) = 21.01, P < 0001). This latent factor were positively associated (r = 0.51, P < 0.001) and presented a good internal consistency (α = 0.85 and α = 0.86 for cognitive-emotional and somatic items, respectively). The invariance factor of two-factor model across gender was also confirmed.ConclusionsResults indicate that within college communities the GAD-7 integrates two stable generalized anxiety factors related but independent structure. The GAD-7 can be an adequate measure to detected generalized anxiety symptoms in this population.Disclosure of interestThe authors have not supplied their declaration of competing interest.