bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterocycles [h]-fused onto 4-oxoquinoline-3-carboxylic acid. Part XII: synthesis of 5-fluoro-7-oxodihydo[1,3,4]thiadiazino [5,6-h]quinoline-8-carboxylic acid and ester
Authors: El-Abadelah Mustafa M. , Abadleh Mohammed M. , Awwadi Firas F. , Sabri Salim S. , Voelter Wolfgang 
Published: December 2017

AbstractDirect interaction of dithizone with 7-chloro-6- fluoro-8-nitro-4-oxoquinoline-3-carboxylic acid or with its ester delivered the corresponding novel 1,3,4-thiadiazino [5,6-h]quinoline 3-carboxylic acid, or its ester which was then hydrolyzed to the respective acid. Structures of the latter tricyclic hybrids were deduced from analytical and spectral data and confirmed by single crystal X-ray structure determination of the ester derivative. The free acid showed moderate activity againstStaphylococcus aureuswith a MIC value of 25 μg mL−1.
Influence of Local Environment on Inner Shell Excitation Spectra, Studied by Electron and X-ray Spectroscopy and Spectromicroscopy
Authors: Hitchcock Adam P. 
Published: December 2017

Abstract
Inner shell excitation spectroscopy is a local probe of the unoccupied electronic structure in the immediate vicinity of the core excited atom. As such, one might expect the inner shell spectrum of a given unit (a molecular fragment or a repeat unit of a solid) to be largely independent of where that unit is located. This is often an implicit assumption in spectral analysis and analytical applications. However, there are situations where inner shell excitation spectra exhibit significant sensitivity to their local environment. Here I categorize the ways in which inner shell spectra are affected by their local environment, and give examples from a career dedicated to developing a better understanding of inner shell excitation spectroscopy, its experimental techniques, and applications.
Green Synthesis of CoFe2O4 and Investigation of its Catalytic Efficiency for Degradation of Dyes in Aqueous Medium
Authors: Saeed Muhammad , Mansha Asim , Hamayun Muhammad , Ahmad Aziz , Ulhaq Atta , Ashfaq Muhammad 
Published: December 2017

Abstract
The catalytic wet oxidation is one the methods used for elimination of dyes from aqueous medium in which various metal based materials can be used as heterogeneous catalysts. Bimetallic oxides as heterogeneous catalysts have gained much attention as bimetallization improve the catalytic properties of the resulting particles. The biosynthetic green method is the most viable and simple method for synthesis of bimetallic oxides nanoparticles. Here, we report the green synthesis of CoFe2O4 particles using Azadirachata indica leaves extract as reducing and stabilizing agent. The synthesized particles were characterized using X-ray diffraction, thermogravimetric analysis, Fourier-transform infrared spectroscopy and scanning electron microscopy. The synthesized CoFe2O4 particles were tested as a catalyst for mineralization of rhodamine B and methylene blue dyes in the presence of hydrogen peroxide in aqueous media. More than 95% dyes degraded in 120 min. The reaction kinetics was described in terms of Langmuir–Hinshelwood mechanism which suggests that molecules of dye and hydrogen peroxide adsorbed surface of CoFe2O4 and then react together.
The Association Between Body Adiposity Measures, Postural Balance, Fear of Falling, and Fall Risk in Older Community-Dwelling Women
Authors: Neri Silvia Gonçalves Ricci , Gadelha André Bonadias , de David Ana Cristina , Ferreira Aparecido Pimentel , Safons Marisete Peralta , Tiedemann Anne , Lima Ricardo M. 
Published: December 2017

Background and Purpose:
Recent investigations demonstrate an association between obesity and the propensity of older adults to fall. The aim of this study was to investigate the association between body adiposity measures, postural balance, fear of falling, and risk of falls in older women.

Methods:
One hundred forty-seven volunteers took part in this cross-sectional study. Participants underwent body composition assessment using dual-energy x-ray absorptiometry and had body mass index, waist circumference (WC), and body adiposity index measured. Postural balance was assessed using a force platform, while fear of falling and risk of falls were, respectively, evaluated by the Falls Efficacy Scale—International and the QuickScreen Clinical Falls Risk Assessment.

Results and Discussion:
All adiposity measures were correlated to at least 1 postural stability parameter and to fear of falling (ρ= 0.163, P < .05 to r = 0.337, P < .001); however, WC was the index most strongly correlated to risk of falls (ρ= 0.325; P < .001). When obesity was classified using WC, it was observed that compared with nonobese individuals (n = 51), obese individuals (n = 96) exhibited greater center of pressure displacement in the anteroposterior and mediolateral axes, especially during conditions with feet apart (P < .05). The obese group also exhibited an increased fear of falling (28.04 vs 24.59; P = .002) and had a higher proportion of individuals with increased fall risk (72% vs 35%; P < .001).

Conclusion:
In summary, adiposity measures are associated with risk of falls in older women, which might be mediated by reduced postural balance and increased fear of falling. Among these indices, WC, an easy and low-cost assessment, demonstrated the strongest association with falls-related outcomes.
Validity and Responsiveness to Change of the 30-Second Chair-Stand Test in Older Adults Admitted to an Emergency Department
Authors: Bruun Inge Hansen , Mogensen Christian B. , Nørgaard Birgitte , Schiøttz-Christensen Berit , Maribo Thomas 
Published: December 2017

Background and Purpose:Few physical performance measurement tools are validated for acutely admitted older adults, and for this reason we aimed to examine the validity and responsiveness to change of the 30-second Chair-Stand Test (30s-CST) used to assess physical performance in older adults admitted to a short-stay unit in an emergency department.Methods:Construct validity of the 30s-CST, using 8 as a cutoff point for dependency in activities of daily living, was examined using 207 patients. Self-reported information on everyday activities was obtained by asking patients about need for help in bathing, dressing, cooking, cleaning, and shopping. Concurrent validity of the 30s-CST compared with the de Morton Mobility Index (DEMMI) on physical performance of acutely admitted older adults was examined with 156 patients. The analysis of concurrent validity included the entire DEMMI and 2 subsets of DEMMI: “DEMMI walking” and “DEMMI dynamic balance.” The responsiveness to change in the 30s-CST compared with DEMMI was examined with 117 patients. All patients were classified as having either low physical performance (30s-CST ≤8) or high physical performance (30s-CST >8); these groups were used in the analysis of validity and responsiveness to change.Results and Discussion:Regarding construct validity using 8 as a cutoff point, the study showed a significant difference between patients with low physical performance compared with patients with high physical performance. Moreover, a decrease in the 30s-CST was followed by an increase in the need for help with everyday activities. There was a significant association between the 30s-CST and DEMMI (r= 0.72); for every extra repetition in the 30s-CST, the DEMMI score increased by 4.9. There was a significant association between the 30s-CST and the 2 subsets “DEMMI walking” and “DEMMI dynamic balance”; yet, a pronounced floor effect was found in the subsets. The analysis demonstrated a very wide prediction interval, indicating that DEMMI has a better responsiveness to change than the 30s-CST, especially in older adults with low physical performance. However, the 30s-CST is easier and faster to use than DEMMI.Conclusion:This study found a significant difference in the patients' need for help with everyday activities when comparing low and high physical performance groups. The concurrent validity of the 30s-CST was acceptable in assessing physical performance in older adults at the time of admission; the 30s-CST is thus a tool that is easy to use in older adults with acute disease. In contrast, based on very wide prediction intervals, DEMMI demonstrated better responsiveness to change than the 30s-CST, especially in older adults with low physical performance.
Meta-analytic and Scoping Study on Strength Training in People With Multiple Sclerosis
Authors: Manca Andrea , Dvir Zeevi , Deriu Franca 
Published: December 2017

Abstract
Manca, A, Dvir, Z, and Deriu, F. Meta-analytic and scoping study on strength training in people with multiple sclerosis. J Strength Cond Res 33(3): 874–889, 2019—Aim of the study was to determine a pooled estimate of effect on muscle strength and functional capacity induced by strength training in people with multiple sclerosis (PwMS). Five databases and 2 public registries were searched from inception to May 2017. Indexing terms used were: “multiple sclerosis,” “resistance training,” and “strength training.” After title/abstract screening, 2 independent reviewers evaluated the studies' eligibility, which were retained if PwMS were randomly assigned to strength training or to a no intervention group. Of the 1,467 items retrieved, 30 randomized controlled trials formed the initial database with 11 trials (426 subjects) entering the final meta-analysis. The quality of the included studies was assessed by the PEDro scale and the risk of bias using the Cochrane Risk-of-Bias tool. All meta-analyses were conducted using a random effects model. After interventions, PwMS increased strength by 23.1% (confidence interval [CI] 11.8–34.4; +12.1 N; CI 4.5–19.8; p = 0.002; n = 366 subjects) at a small-to-moderate effect size (0.37; CI 0.2–0.6). Walking speed increased by 16.3 ± 10.7% (p = 0.0002; effect size 0.54; n = 275 subjects), distance covered in the 2-minute walking test by 6.7 ± 6.4% (p = 0.04; effect size 0.50; n = 111 subjects). People with MS respond to resistance training with consistent strength gains. Methodological inconsistencies among studies and inadequate reporting of the findings limited a comprehensive determination of the impact of strength improvements on patient functioning, except for walking performance which seemed significantly improved. Methodological steps and scoping lines are provided to establish a common platform for future trials.
Lower-Limb Stiffness and Maximal Sprint Speed in 11–16-Year-Old Boys
Authors: Meyers Robert W. , Moeskops Sylvia , Oliver Jon L. , Hughes Michael G. , Cronin John B. , Lloyd Rhodri S. 
Published: December 2017

Abstract
Meyers, RW, Moeskops, S, Oliver, JL, Hughes, MG, Cronin, JB, and Lloyd, RS. Lower-limb stiffness and maximal sprint speed in 11–16-year-old boys. J Strength Cond Res 33(7): 1987–1995, 2019—The purpose of the study was to examine the relationship between vertical stiffness, leg stiffness, and maximal sprint speed in a large cohort of 11–16-year-old boys. Three-hundred thirty-six boys undertook a 30-m sprint test using a floor-level optical measurement system, positioned in the final 15-m section. Measures of speed, step length, step frequency, contact time, and flight time were directly measured while force, displacement, vertical stiffness, and leg stiffness, were modeled from contact and flight times, from the 2 fastest consecutive steps for each participant over 2 trials. All force, displacement, and stiffness variables were significantly correlated with maximal sprint speed (p ≤ 0.05). Relative vertical stiffness had a very large (r > 0.7) relationship with sprint speed, whereas vertical center of mass displacement, absolute vertical stiffness, relative peak force, and maximal leg spring displacement had large (r > 0.5) relationships. Relative vertical stiffness and relative peak force did not significantly change with advancing age (p > 0.05), but together with maximal leg spring displacement accounted for 96% of the variance in maximal speed. It seems that relative vertical stiffness and relative peak force are important determinants of sprint speed in boys aged 11–16 years, but are qualities that may need to be trained because of no apparent increases from natural development. Practitioners may wish to use training modalities such as plyometrics and resistance training to enable adaptation to these qualities because of their importance as predictors of speed in youth.
Mechanisms Behind Blood Flow–Restricted Training and its Effect Toward Muscle Growth
Authors: Hwang Paul S. , Willoughby Darryn S. 
Published: December 2017

Abstract
Hwang, P and Willoughby, DS. Mechanisms behind blood flow–restricted training and its effect toward muscle growth. J Strength Cond Res 33(7S): S167–S179, 2019—It is widely established throughout the literature that skeletal muscle can induce hypertrophic adaptations after progressive overload of moderate-to-high-intensity resistance training. However, there has recently been a growing body of research that shows that the combination of blood flow–restricted (BFR) training with low-intensity resistance exercise can induce similar gains in muscular strength and hypertrophic adaptations. The implementation of external pressure cuffs over the most proximal position of the limb extremities with the occlusion of venous outflow of blood distal to the occlusion site defines the BFR training protocol. There are various mechanisms through which BFR training may cause the stimulations for skeletal muscle hypertrophy and increases in strength. These may include increases in hormonal concentrations, increases within the components of the intracellular signaling pathways for muscle protein synthesis such as the mTOR pathway, increases within biomarkers denoting satellite cell activity and apparent patterns in fiber type recruitment. There have also been scientific findings demonstrating hypertrophic effects within both BFR limbs and non-BFR muscles during BFR training programs. The purpose behind this critical review will be to provide a comprehensive discussion on relevant literature that can help elucidate the potential underlying mechanisms leading to hypertrophic adaptations after BFR training programs. This review will also explicate the various findings within the literature that focalizes on both BFR limb and non-BFR muscle hypertrophy after bouts of BFR training. Furthermore, this critical review will also address the various needs for future research in the many components underlying the novel modality of BFR training.
Positional Demands and Physical Activity Profiles of Netball
Authors: van Gogh Mikah J. , Wallace Lee K. , Coutts Aaron J. 
Published: December 2017

Abstract
van Gogh, MJ, Wallace, LK, and Coutts, AJ. Positional demands and physical activity profiles of netball. J Strength Cond Res 34(5): 1422–1430, 2020—The aim of this study was to examine the activity profiles and physiological demands of netball. Eleven representative youth netball players participated in this study. Global positioning system, heart rate, and accelerometer data were collected during 8 competitive matches. Sport-specific skills were analyzed using notational methods. The main findings were that players traveled less distance during a match than previously reported. The center covered significantly greater distances than the other positions (p < 0.001). The goal shooter and goal keeper covered the least distance and endured lower accelerometer loads than other positions (p < 0.001). Very low levels of very high-speed running and sprint efforts were observed across all positions. The proportion of time spent in the high (>85% maximum heart rate [HRmax]) HR zone ranged from 7.0 to 62.6%, highlighting a high variation in cardiovascular demands between each position. The center and goal attack had the greatest cardiovascular demands spending significantly more time in the high (>85% HRmax) HR zone (p < 0.001). The goal shooter and goal keeper spent significantly more time in the low (<70% HRmax) HR zone (p < 0.001). Players in attacking positions were shown to pass/catch significantly more players than in defending positions (p < 0.001). Players in defending positions had higher number of deflections and intercepts compared with players in attacking positions (p < 0.001). These findings reveal significant positional differences in activity profiles and movement demands in netball. These data can be used to refine position-specific training practice and guide tactical strategies during competition.
Maturity Status as a Determinant of the Relationships Between Conditioning Qualities and Preplanned Agility in Young Handball Athletes
Authors: Hammami Raouf , Sekulic Damir , Selmi Mohamed Amin , Fadhloun Mourad , Spasic Miodrag , Uljevic Ognjen , Chaouachi Anis 
Published: December 2017

Abstract
Hammami, R, Sekulic, D, Selmi, MA, Fadhloun, M, Spasic, M, Uljevic, O, and Chaouachi, A. Maturity status as a determinant of the relationships between conditioning qualities and preplanned agility in young handball athletes. J Strength Cond Res 32(8): 2302–2313, 2018—Studies performed thus far have not accounted for the potential influence of maturity on determinants of preplanned agility. This study aimed to examine how determinants of preplanned agility are affected by the period of peak height velocity (PHV) regarding the anthropometrics and conditioning qualities in young handball players. The sample comprised 56 handball players (male; 12–14 years of age), allocated into 2 groups according to their biological age of maturity: Pre-PHV (N = 34) and Post-PHV (N = 22). Players were evaluated on handball-specific tests of preplanned agility (CODAT and T-HALF). Predictors included anthropometrics, sprinting, horizontal and vertical jumps, and reactive strength index (RSI). The reliability of the tests was appropriate (intraclass correlation coefficient: 0.87–0.95; coefficient of variation: 4.4–5.8%). In the Pre-PHV group, 67% variance of the T-HALF accounted for horizontal countermovement jump (β: −0.83, p < 0.01), 20-m sprint (β: 0.91, p < 0.01), and body mass (β: 0.19, p = 0.02). In the Post-PHV group, 80% of the T-HALF variance was explained, with a significant influence of 20-m sprint (β: 0.52, p < 0.01), RSI (β: −0.24, p = 0.04), and standing long jump (β: −0.57, p = 0.03). In the Pre-PHV group, 45% of the CODAT variance accounted for the partial influence of body fat percentage (β: 0.44, p = 0.04) and a 20-m sprint (β: 0.74, p < 0.01). In the Post-PHV group, the predictors accounted for 79% of the CODAT variance, with a significant influence of the RSI (β: −0.26, p = 0.04) and a 10-m sprint (β: 0.87, p = 0.03). Our results reinforce the need for differential strength and conditioning programs aimed at improving the preplanned agility of young athletes who differ in maturity status.
Detailed Dendritic Excitatory/Inhibitory Balance through Heterosynaptic Spike-Timing-Dependent Plasticity
Authors: Hiratani Naoki , Fukai Tomoki 
Published: December 2017

The balance between excitatory and inhibitory inputs is a key feature of cortical dynamics. Such a balance is arguably preserved in dendritic branches, yet its underlying mechanism and functional roles remain unknown. In this study, we developed computational models of heterosynaptic spike-timing-dependent plasticity (STDP) to show that the excitatory/inhibitory balance in dendritic branches is robustly achieved through heterosynaptic interactions between excitatory and inhibitory synapses. The model reproduces key features of experimental heterosynaptic STDP well, and provides analytical insights. Furthermore, heterosynaptic STDP explains how the maturation of inhibitory neurons modulates the selectivity of excitatory neurons for binocular matching in the critical period plasticity. The model also provides an alternative explanation for the potential mechanism underlying the somatic detailed balance that is commonly associated with inhibitory STDP. Our results propose heterosynaptic STDP as a critical factor in synaptic organization and the resultant dendritic computation.SIGNIFICANCE STATEMENTRecent experimental studies reveal that relative differences in spike timings experienced among neighboring glutamatergic and GABAergic synapses on a dendritic branch significantly influences changes in the efficiency of these synapses. This heterosynaptic form of spike-timing-dependent plasticity (STDP) is potentially important for shaping the synaptic organization and computation of neurons, but its functional role remains elusive. Through computational modeling at the parameter regime where previous experimental results are well reproduced, we show that heterosynaptic plasticity serves to finely balance excitatory and inhibitory inputs on the dendrite. Our results suggest a principle of GABA-driven neural circuit formation.
Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis
Authors: Grund Thomas , Goyon Stephanie , Li Yuting , Eliava Marina , Liu Haikun , Charlet Alexandre , Grinevich Valery , Neumann Inga D. 
Published: December 2017

Neuropeptides, such as neuropeptide S (NPS) and oxytocin (OXT), represent potential options for the treatment of anxiety disorders due to their potent anxiolytic profile. In this study, we aimed to reveal the mechanisms underlying the behavioral action of NPS, and present a chain of evidence that the effects of NPS within the hypothalamic paraventricular nucleus (PVN) are mediated via actions on local OXT neurons in male Wistar rats. First, retrograde studies identified NPS fibers originating in the brainstem locus coeruleus, and projecting to the PVN. FACS identified prominent NPS receptor expression in PVN-OXT neurons. Using genetically encoded calcium indicators, we further demonstrated that NPS reliably induces a transient increase in intracellular Ca2+concentration in a subpopulation of OXT neurons, an effect mediated by NPS receptor. In addition, intracerebroventricular (i.c.v.) NPS evoked a significant somatodendritic release of OXT within the PVN as assessed by microdialysis in combination with a highly sensitive radioimmunoassay. Finally, we could show that the anxiolytic effect of NPS seen after i.c.v. or intra-PVN infusion requires responsive OXT neurons of the PVN and locally released OXT. Thus, pharmacological blockade of OXT receptors as well as chemogenetic silencing of OXT neurons within the PVN prevented the effect of synthetic NPS. In conclusion, our results indicate a significant role of the OXT system in mediating the effects of NPS on anxiety, and fill an important gap in our understanding of brain neuropeptide interactions in the context of regulation of emotional behavior within the hypothalamus.SIGNIFICANCE STATEMENTGiven the rising scientific interest in neuropeptide research in the context of emotional and stress-related behaviors, our findings demonstrate a novel intrahypothalamic mechanism involving paraventricular oxytocin neurons that express the neuropeptide S receptor. These neurons respond with transient Ca2+increase and somatodendritic oxytocin release following neuropeptide S stimulation. Thereby, oxytocin neurons seem essential for neuropeptide S-induced anxiolysis, as this effect was blocked by pharmacological and chemogenetic inhibition of the oxytocin system.