bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between psychosocial factors and long‐term opioid use among injured workers receiving early opioids
Authors: Elmore Andrea , Fulton‐Kehoe Deborah , Arewasikporn Anne , Haight John R. , Franklin Gary M. 
Published: September 2024

AbstractBackgroundLong‐term opioid use is related to numerous harms and has uncertain efficacy for chronic, non‐cancer pain. Identification of individuals at risk for long‐term opioid use can help support treatment decisions. The aim of this study was to determine psychosocial factors associated with opioid use 6 months after a work‐related injury.MethodsThis was a prospective observational cohort study incorporating surveys and administrative data. Eligibility included a workers' compensation claim for an injury between June 2019 and September 2021, no opioid use within 3 months before injury, and opioid use within 6 weeks after injury. The outcome was self‐reported opioid use at the 6‐month follow‐up survey (no use, use some days, or use most or every day). Multinomial logistic regression models were used to calculate relative risk ratios (RRRs) for associations between self‐reported psychosocial factors and long‐term opioid use.ResultsOf the 1724 respondents, 301 (17.5%) reported taking long‐term opioids on some days and 87 (5.0%) reported taking long‐term opioids on most or every day. After adjustment for sociodemographic and clinical covariates, workers reporting work fear‐avoidance had a higher relative risk of opioid use most or every day, versus no opioid use at the 6‐month survey, compared to those without work fear‐avoidance (RRR = 1.95, 95% CI = 1.08, 3.50). Anxiety symptoms, depression symptoms, and recovery expectations were not associated with long‐term opioid use after covariate adjustment.ConclusionsWork fear‐avoidance was associated with long‐term opioid use in this study of injured workers. Addressing fears surrounding an injury and returning to work may help deter reliance on long‐term opioids.
Living Cell‐Mediated Catalyst‐Free Spontaneous Polymerization of Zwitterionic Methacrylates for Preparation of Probiotic‐Loaded Hydrogels
Authors: Li Yuke , Huang Yiming , Gao Zhiqiang , Song Gang , Lv Fengting , Bai Haotian , Wang Shu 
Published: October 2024

AbstractLiving cell‐mediated polymerization offers promising applications in biomaterials, yet its further biological utilization is hindered by the need for metal ions or radical initiators with available methods. In this study, we introduce a living cell‐mediated polymerization that leverages the intrinsic metabolic activities of living cells to initiate and sustain free radical polymerization of zwitterionic methacrylates. The polymerization proceeded in the absence of transition metal catalysts, radical initiators, or light sources. The conversion of zwitterionic methacrylate strongly correlated with cellular activities and achieved a maximum conversion of 98 % within 48 hours. Living cells efflux redox power across membranes through metabolism and that terminal electron fluxes are captured by zwitterionic methacrylates pre‐assembled on the living cell surface to initiate radical polymerization reactions. The polymerization caused significant changes to the cell membrane surface and synthesized hydrogels with tailored mechanical properties. The polymer hydrogel obtained via probiotic E. coli Nissle 1917 was able to release the in situ encapsulated molecules, which demonstrated living cell‐mediated polymer hydrogel as a vehicle for the delivery of both cellular and molecular therapeutic agents. This research offered a green and efficient method for synthesizing bioactive materials and advancing the field of cellular therapeutics and drug delivery.
Stabilisation of Bromenium Ions in Macrocyclic Halogen Bond Complexes
Authors: Docker Andrew , Kuhn Heike , Beer Paul D. 
Published: October 2024

AbstractHalenium ions (X+) are highly reactive electron deficient species that are prevalent transient intermediates in halogenation reactions. The stabilisation of these species is especially challenging, with the most common approach to sequester reactivity through the formation of bis‐pyridine (Py) complexes; [(Py)2X]+. Herein, we present the first example of a macrocyclic stabilisation effect for halenium species. Exploiting a series of bis‐pyridine macrocycles, we demonstrate that preorganised macrocyclic ligands stabilise bromenium cations via endotopic complexation, impressively facilitating the isolation of a bench stable ‘Br+ NO3−’ species. Solid state X‐ray crystallographic structural comparison of macrocyclic Br(I) complexes with Ag(I) and Au(I) analogues provides insightful information concerning similarities and stark contrasts in halenium/metal cation coordination behaviors. Furthermore, the first chemical ligand exchange reactions of Br(I) complexes are reported between acyclic [(Py)2Br]+ species and a bis‐pyridine macrocyclic donor ligand which importantly highlights a macrocycle effect for halenium cation stabilisation in the solution phase.
Selective Methylation of Cyclic Ether Towards Highly Elastic Solid Electrolyte Interphase for Silicon‐based Anodes
Authors: Ma Zhihao , Ruan Digen , Wang Dazhuang , Lu Zongbin , He Zixu , Guo Jiasen , Fan Jiajia , Jiang Jinyu , Wang Zihong , Luo Xuan , Ma Jun , Zhang Ze , You Yezi , Jiao Shuhong , Cao Ruiguo , Ren Xiaodi 
Published: October 2024

AbstractSilicon (Si)‐based anodes offer high theoretical capacity for lithium‐ion batteries but suffer from severe volume changes and continuous solid electrolyte interphase (SEI) degradation. Here, we address these challenges by selective methylation of 1,3‐dioxolane (DOL), thus shifting the unstable bulk polymerization to controlled interfacial reactions and resulting in a highly elastic SEI. Comparative studies of 2‐methyl‐1,3‐dioxolane (2MDOL) and 4‐methyl‐1,3‐dioxolane (4MDOL) reveal that 4MDOL, with its larger ring strain and more stable radical intermediates due to hyperconjugation effect, promotes the formation of high‐molecular‐weight polymeric species at the electrode‐electrolyte interface. This elastic, polymer‐rich SEI effectively accommodates volume changes of Si and inhibits continuous side reactions. Our designed electrolyte enables Si‐based anode to achieve 85.4 % capacity retention after 400 cycles at 0.5 C without additives, significantly outperforming conventional carbonate‐based electrolytes. Full cells also demonstrate stable long‐term cycling. This work provides new insights into molecular‐level electrolyte design for high‐performance Si anodes, offering a promising pathway toward next‐generation lithium‐ion batteries with enhanced energy density and longevity.
KCl supported by γ‐Al2O3 for selective adsorption of gaseous oxidized mercury: Preparation and adsorption mechanism
Authors: Tong Jiangyi , Li Haiyang , Jin Rui , Liu Xiaoshuo , Hu Haitao , Duan Yufeng , Ma Xiuyuan , Zhong Li , Han Lipeng 
Published: September 2024

AbstractThe separation of Hg0 and HgCl2 with selective adsorbents is crucial for mercury speciation detection. KCl is commonly used but has a limited surface area, a short lifespan, and an unclear mechanism for Hg0/HgCl2 adsorption. Hence, KCl supported by γ‐Al2O3 to create a high‐surface‐area selective adsorbent to enhance practical performance was proposed and the selective adsorption mechanisms of Hg0 and HgCl2 through experimental investigations and density functional theory (DFT) calculations were elucidated. Compared to the total breakthrough of pure KCl, that of KCl/γ‐Al2O3 exhibits markedly selective adsorption efficacy on HgCl2, with a nearly complete breakthrough rate on Hg0 at a KCl‐to‐γ‐Al2O3 molar ratio of 1, attributed to their favorable porosity and dispersed active sites. The DFT results verify a weak van der Waals force between KCl and Hg0, indicating physisorption, while covalent bonding occurs between KCl and HgCl2, suggesting chemisorption. High‐resolution transmission electron microscopy (HRTEM) identifies two crystalline surfaces of 001 and 011 on the developed adsorbent. This clarifies three stable adsorption configurations: 001 Top‐Cl, 011 Top‐Cl, and 011 Cl–Cl bridge, with adsorption energies of −87.11, −110.74, and −174.91 kJ/mol, respectively. Analyses of the electronic structure and interaction region indicator (IRI) reveal that the Hg atom within HgCl2 forms covalent bonds with unsaturated Cl atoms on the KCl surface. Additionally, integrated crystal orbital Hamilton population (ICOHP) analysis and electron transfer results demonstrate that the interaction strength of the three configurations with HgCl2 follows the order of 011 Cl–Cl bridge > 011 Top‐Cl > 001 Top‐Cl. This matches the three different temperature peaks of 276, 231, and 120°C, respectively, in the analysis of the temperature‐programmed desorption of HgCl2 (HgCl2‐TPD). This study offers a novel insight on mercury speciation partitioning between Hg0 and HgCl2.
Luminescence properties of Sr2Ga2GeO7:Bi3+ phosphors and temperature sensing characteristics of co‐doped Sm3+
Authors: Wan Jiangyun , Wu Haoyi , Li Yanmei , Chen Yonglin , Peng Chaoyue , Chen Geng , Hu Yihua 
Published: October 2024

AbstractAs one of the fundamental physical quantities, temperature is extremely important in various fields. In order to study the temperature sensing characteristics of dual‐emitting center phosphors, Bi3+‐doped and Bi3+/Sm3+‐doped Sr2Ga2GeO7 phosphors were synthesized by high‐temperature solid‐phase method. Under 312 nm excitation, the Sr2Ga2GeO7:Bi3+ phosphor exhibits a blue broadband emission corresponding to the 3P1 → 1S0 transition of Bi3+ ions. By testing the temperature change spectrum of phosphors, it was found that Bi3+ exhibited strong thermal sensitivity. However, due to the fact that single ion doped phosphors are easily affected by other factors when applied to the field of temperature sensing, based on the thermal sensitivity of Bi3+, Sm3+ with low temperature sensitivity was selected as the co‐doped ion, and it was found that the two ions had different thermal quenching characteristics when the temperature change spectrum was tested. Using the temperature detection method based on the fluorescence intensity ratio (FIR) of the dual emission centers, it was found that the best absolute sensitivity Sa was 3.125% K−1 and the maximum relative sensitivity Sr was 1.275% K−1 in the range of 303–423 K. These results show that Sr2Ga2GeO7:Bi3+/Sm3+ phosphors have broad application prospects in the field of optical temperature sensing.
Evidence driven indoor air quality improvement: An innovative and interdisciplinary approach to improving indoor air quality
Authors: Lovrić Mario , Gajski Goran , Fernández‐Agüera Jessica , Pöhlker Mira , Gursch Heimo ,   The EDIAQI Consortium, Borg Alex , Switters Jon , Mureddu Francesco 
Published: October 2024

AbstractIndoor air pollution is a recognized emerging threat, claiming millions of lives annually. People are constantly exposed to ambient and indoor air pollution. The latest research shows that people in developed countries spend up to 90% of their time indoors and almost 70% at home. Although impaired Indoor Air Quality (IAQ) represents a significant health risk, it affects people differently, and specific populations are more vulnerable: children, the elderly, and people with respiratory illnesses are more sensitive to these environmental risks. Despite rather extensive research on IAQ, most of the current understanding about the subject, which includes pollution sources, indoor–outdoor relationships, and ventilation/filtration, is still quite limited, mainly because air quality monitoring in the EU is primarily focused on ambient air quality and regulatory requirements are lacking for indoor environments. Therefore, the EDIAQI project aims to improve guidelines and awareness for advancing the IAQ in Europe and beyond by allowing user‐friendly access to information about indoor air pollution exposures, sources, and related risk factors. The solution proposed with EDIAQI consists of conducting a characterization of sources and routes of exposure and dispersion of chemical, biological, and emerging indoor air pollution in multiple cities in the EU. The project will deploy cost‐effective/user‐friendly monitoring solutions to create new knowledge on sources, exposure routes, and indoor multipollutant body burdens. The EDIAQI project brings together 18 organizations from 11 different European countries that provide interdisciplinary skills and expertise in various fields, including environmental science and technology, medicine, and toxicology, as well as policy design and public engagement.
Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach
Authors: Qin Wenjie , Deng Yinhua , Ren Huan , Liu Yanling , Liu Ling , Liu Wenhui , Zhao Yuxi , Li Chen , Yang Zhiling 
Published: October 2024

AbstractBackground and AimsCardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (PISA), focusing on the interaction with key proteins implicated in cellular metabolism and mitochondrial function.MethodsWe conducted lysate‐based and intact‐cell PISA assays on cancer cells treated with CGs (Digoxin, Digitoxin, Ouabain) to analyze protein solubility changes. This was followed by mass spectrometric analysis and bioinformatics to identify differentially soluble proteins (DSPs). Molecular docking simulations were performed to predict protein‐CG interactions. Public data including gene expression changes upon CG treatment were re‐analyzed for validation.ResultsThe PISA assays revealed CGs’ broad‐spectrum interactions, particularly affecting proteins like PKM2, ANXA2, SLC16A1, GOT2 and GLUD1. Molecular docking confirmed stable interactions between CGs and these DSPs. Re‐analysis of public data supported the impact of CGs on cancer metabolism and cell signaling pathways.ConclusionOur findings suggest that CGs could be repurposed for cancer therapy by modulating cellular processes. The PISA data provide insights into the polypharmacological effects of CGs, warranting further exploration of their mechanisms and clinical potential.
A Comprehensive Quality Evaluation for Gentiana Rigescens Franch. by Fingerprinting Combined with Chemometrics and Network Pharmacology
Authors: Li Chaoping , Zhu Xinyan , Shen Tao , Wang Yuanzhong , Zhang Rongping 
Published: October 2024

AbstractGentiana rigescens Franch. (G. rigescens) is a unique traditional medicinal herb from southwestern China, and its clinical mechanism for the treatment of hepatitis and the quality differences between different origins are not clear. The research aims to analyze the mechanisms for the treatment of hepatitis and differences in inter‐origin differences using analytical techniques, chemometrics, and network pharmacology. Through infrared spectroscopy, spectral images, and high‐performance liquid chromatography (HPLC) analysis, it was found that there were differences in absorbance intensity and significant differences in compound content among the samples’ origin. G. rigescens iridoids and flavonoids exert therapeutic effects on hepatitis through multiple targets (GAPDH, EGFR, and MMP9, etc.) and multiple pathways (non‐small cell lung cancer, hepatitis C, etc.). The above HPLC, chemometrics, and network pharmacology results revealed that gentiopicroside, and swertiamarine was the best quality marker among origins. The accuracy of the ResNet model train, test, and external validation sets for synchronous spectral images were 100 %, which could be utilized as an effective tool for tracing G. rigescens's origins. The R2 of the calibration and validation sets of the PLSR model was higher than 0.70. This model had excellent predictive performance in determining the content of gentiopicroside and swertiamarine, and could quickly, accurately, and effectively predict these two compounds. The research investigates the differences in G. rigescens origins from multiple perspectives, establishes image recognition models and prediction models, and provides new methods and theoretical basis for quality control of G. rigescens.
Anxiolytic and Anticonvulsant Potential of Biosynthetic Limonene Derivatives in Adult Zebrafish
Authors: Cavalcante Rafaela Mesquita Bastos , Ferreira Maria Kueirislene Amâncio , Wlisses da Silva Antonio , Mendes Francisco Rogenio da Silva , Guimarães Lemos Cecília , Bezerra Maciel Jéssica , Rocha Cavalcante Thaís , Silva Marinho Emmanuel , Alencar de Menezes Jane Eire Silva , dos Santos Helcio Silva 
Published: October 2024

AbstractThis study investigated the anxiolytic and anticonvulsant effects and safety profile of limonene enantiomers and their oxidized derivatives. The toxicity test was performed by monitoring the animals for 96 hours, with no deaths or significant toxicity observed up to the highest dose, which allowed the determination of the LD50. Doses of 4, 20 and 40 mg/kg were tested, with no toxicity observed up to 96 h (LD50>40 mg/kg). Anxiolytic activity was measured in a preference test for light and dark areas, and the effect of the compounds was evaluated in the presence of serotonergic antagonists. The (S)‐(−)‐LIM and (R)‐(+)‐LIM enantiomers showed anxiolytic effects, with (S)‐(−)‐LIM being effective at all doses. In the anticonvulsant test, the oxidized derivatives, such as perilyl acid (PAC), significantly delayed PTZ‐induced seizures, an effect blocked by flumazenil (FMZ). The oxidized derivatives, especially perilyl acid (PAC), showed anxiolytic effects at all doses and significantly delayed the three PTZ‐induced seizure events. This effect was blocked by FMZ, suggesting a relationship between PAC and the GABAergic pathway. PAC, being the most oxidized derivative, was the most effective for both anxiety and delaying seizure progression, suggesting that oxidation of limonene compounds may increase their therapeutic efficacy.
Predictors of recurrent restenosis after repeat drug‐coated balloon therapy for drug‐coated balloon restenosis in femoropopliteal lesions: Results of the RECURRENCE study
Authors: Yanagiuchi Takashi , Fukai Kuniyoshi , Sogabe Koji , Iwasaki Yoshihiro , Hirano Keita , Kato Taku , Yokoi Hirokazu , Zen Kan , Matoba Satoaki 
Published: October 2024

AbstractBackgroundDespite the widespread use of drug‐coated balloons (DCBs) for femoropopliteal (FP) lesions, there is still no consensus on treatment strategies for DCB restenosis. This study aimed to determine the risk factors for recurrent restenosis after repeat DCB therapy for DCB restenosis in FP lesions.MethodsThis multicenter retrospective study assessed 1176 consecutive limbs in 860 patients who successfully received initial DCB therapy for FP lesions at four cardiovascular centers between May 2018 and December 2022. Among these patients, 118 consecutive limbs of 104 patients treated via repeat DCB for primary DCB restenosis were enrolled.ResultsThe Kaplan–Meier estimate of freedom from recurrent restenosis was 74.6% at 1 year. Cox proportional hazard multivariate analysis revealed that recurrent restenosis was independently associated with the time from initial DCB to primary restenosis (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.79–0.92; p < 0.001), history of ≥2 endovascular therapies (EVTs) (HR, 3.11; 95%CI, 1.36–7.12; p = 0.007), and PACSS grade 3 or 4 (HR, 2.76; 95%CI, 1.15–6.63; p = 0.023). Furthermore, receiver operating characteristic curve analysis showed that the cutoff value of the time from initial DCB to primary restenosis to prevent recurrent restenosis was 12.6 months, with an area under the curve of 0.841 (p < 0.001).ConclusionRepeat DCB therapy for DCB restenosis might be an acceptable strategy, particularly for restenosis that occurred more than 12.6 months after initial DCB, given the rate of freedom from recurrent restenosis.
Intestinal ischemia: A rare and less common complication after laparoscopic cholecystectomy—A case report and literature review
Authors: Ghamari Mohammad Javad , Beyzaii Hamed , Bahraminejad Behnoush , Mesbah Narges , Sobhani Ahmadreza , Mirsadeghi Ali 
Published: October 2024

Key Clinical MessagePatients with a history of persistent mesenteric ischemia should not undergo laparoscopy. Mesenteric ischemia must be kept in mind for patients who develop nonspecific abdominal symptoms following laparoscopic surgeries.AbstractDuring laparoscopic cholecystectomy (LC), the rise in Intra‐Abdominal Pressure due to carbon dioxide insufflation can reduce blood flow through splanchnic vessels, potentially leading to intestinal ischemia. A 72‐year‐old woman with a history of diabetes, hypertension, ischemic heart disease, and hyperlipidemia underwent LC. She was discharged but readmitted 4 days later due to peritonitis. Ischemic jejunum loops were found during surgery.
Breastfeeding experiences among young breast cancer survivors: A survey study
Authors: Sella Tal , Sorouri Kimia , Rosenberg Shoshana M. , Loucks Maggie , Kirkner Gregory , Snow Craig , Ruddy Kathryn J. , Gelber Shari I. , Tamimi Rulla M. , Peppercorn Jeffrey M. , Schapira Lidia , Borges Virginia F. , Come Steven E. , Warner Ellen , Partridge Ann H. 
Published: September 2024

ABSTRACTBackgroundFollowing breast cancer (BC), many young women are interested in future childbearing and some may wish to breastfeed. However, limited information is available regarding their lactation experiences.MethodsParticipants in the Young Women's Breast Cancer Study, a multicenter, prospective cohort study of women ≤40 years diagnosed with stage 0–III BC between 2006–2016 and who reported one or more live births following diagnosis, were surveyed about pregnancy and breastfeeding after BC treatment, including reasons for attempting and stopping breastfeeding, satisfaction, and supports.ResultsOf 143 eligible women sent a survey, 115 responded and 94 were included in the analytic cohort. Breastfeeding was attempted by 55% of women (52 of 94). Among those who had not attempted, 93% noted prior bilateral mastectomies (39 of 42). Among those who attempted breastfeeding, 69% had undergone lumpectomy and radiotherapy (36 of 52), 83% of whom reported no milk production from their treated breast (30 of 36). Most (65%, 34 of 52) were at least somewhat satisfied with their ability to breastfeed. Reasons for stopping breastfeeding included: having completed the planned duration (36%, 19 of 52); to start/resume endocrine therapy (21%, 11 of 52); and to resume breast imaging (8%, 4 of 52). Approximately half (27 of 55) of women who had not undergone bilateral mastectomies recalled receiving specific information about breastfeeding after BC, mostly from the oncology team (59%, 16 of 27), online resources (48%, 13 of 27), or a lactation consultant (44%, 12 of 27).ConclusionMost young BC survivors who attempted to breastfeed were able to and were satisfied with the experience, despite challenges. Specific resources to support BC survivors who wish to breastfeed are needed.
Photosensitizer‐Free Benzo[1,4]oxazin‐2‐one Synthesis by Continuous‐Flow Photochemistry
Authors: Park Eunhui , Tambe Shrikant D. , Lee Jongbok , Cho Eun Jin 
Published: October 2024

AbstractWe report a photosynthetic method for producing 2H‐benzo[b][1,4]oxazin‐2‐ones from aryl azides and α‐ketoacids. This method is highly sustainable, requiring only visible light irradiation of the substrates and no external additives. Furthermore, we implemented a continuous‐flow system to achieve efficient light irradiation and rapid mixing, significantly improving reaction efficiency and reducing reaction time compared to the batch process. The flow system enabled gram‐scale synthesis. We also demonstrated the utility of the products, by employing the benzo[1,4]oxazin‐2‐one moiety as a directing group for C−H activation on the 3‐aryl substituent. This green approach highlights the potential for developing environmentally friendly synthetic processes.