bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insurance denials for cancer clinical trial participation after the Affordable Care Act mandate
Authors: Mackay Christine B. , Antonelli Kaitlyn R. , Bruinooge Suanna S. , Saint Onge Jarron M. , Ellis Shellie D. 
Published: March 2017

BACKGROUNDThe Affordable Care Act (ACA) includes a mandate requiring most private health insurers to cover routine patient care costs for cancer clinical trial participation; however, the impact of this provision on cancer centers’ efforts to accrue patients to clinical trials has not been well described.METHODSFirst, members of cancer research centers and community‐based institutions (n = 252) were surveyed to assess the status of insurance denials, and then, a focused survey (n = 77) collected denial details. Univariate and multivariate analyses were used to examine associations between the receipt of denials and site characteristics.RESULTSOverall, 62.7% of the initial survey respondents reported at least 1 insurance denial during 2014. Sites using a precertification process were 3.04 times more likely to experience denials (95% confidence interval, 1.55‐5.99;P ≤ .001), and similar rates of denials were reported from sites located in states with preexisting clinical trial coverage laws versus states without them (82.3% vs 85.1%; χ = 50.7;P ≤ .001). Among the focused survey sites, academic centers reported denials more often than community sites (71.4% vs 46.4%). The failure of plans to cover trial participation was cited as the most common reason provided for denials (n = 33 [80.5%]), with nearly 80% of sites (n = 61) not receiving a coverage response from the insurer within 72 hours.CONCLUSIONSDespite the ACA's mandate for most insurers to cover routine care costs for cancer clinical trial participation, denials and delays continue. Denials may continue because some insurers remain exempt from the law, or they may signal an implementation failure. Delays in coverage may affect patient participation in trials. Additional efforts to eliminate this barrier will be needed to achieve federal initiatives to double the pace of cancer research over the next 5 years. Future work should assess the law's effectiveness at the patient level to inform these efforts.Cancer2017;123:2893–900.©2017 American Cancer Society.
PRAGMA‐ENT: An International SDN testbed for cyberinfrastructure in the Pacific Rim
Authors: Ichikawa Kohei , U‐Chupala Pongsakorn , Huang Che , Nakasan Chawanat , Liu Te‐Lung , Chang Jo‐Yu , Ku Li‐Chi , Tsai Whey‐Fone , Haga Jason , Yamanaka Hiroaki , Kawai Eiji , Kido Yoshiyuki , Date Susumu , Shimojo Shinji , Papadopoulos Philip , Tsugawa Mauricio , Collins Matthew , Jeong Kyuho , Figueiredo Renato , Fortes Jose 
Published: March 2017

SummaryThe Pacific Rim Application and Grid Middleware Assembly (PRAGMA) is an international community of researchers that actively collaborate to address problems and challenges of common interest in eScience. The PRAGMA Experimental Network Testbed (PRAGMA‐ENT) was established with the goal of constructing an international software‐defined network (SDN) testbed to offer the necessary networking support to the PRAGMA cyberinfrastructure. PRAGMA‐ENT is isolated, and PRAGMA researchers have complete freedom to access network resources to develop, experiment, and evaluate new ideas without the concerns of interfering with production networks.In the first phase, PRAGMA‐ENT focused on establishing an international L2 backbone. With support from the Florida Lambda Rail, Internet2, PacificWave, Japan Gigabit Network, and TaiWan Advanced Research and Education Network, PRAGMA‐ENT backbone connects openflow‐enabled switches at University of Florida, University of California, San Diego, Nara Institute of Science and Technology (Japan), Osaka University (Japan), National Institute of Advanced Industrial Science and Technology (Japan), and National Applied Research Laboratories (Taiwan).The second phase of PRAGMA‐ENT consisted of an evaluation of technologies for the control plane that enables multiple experiments (ie, OpenFlow controllers) to coexist. Preliminary experiments with FlowVisor revealed some limitations leading to the development of a new approach, called AutoVFlow.This paper describes our experience in the establishment of PRAGMA‐ENT backbone (with international L2 links), its current status, and plans for the control plane. Discussion of preliminary application ideas, including optimization of routing control; multipath routing control; extending the backbone using overlay network; and remote visualization are also discussed.
Generation of Aromatic (Dehydro)benzoannulene Dications Stabilized by Platinum Catecholate Complexes
Authors: Tahara Kazukuni , Kozuma Hiroyoshi , Venkatesh Varadhachari , Ryomura Eri , Miyoshi Hirokazu , Nakamachi Keigo , Kishi Ryohei , Takahashi Hideaki , Nakano Masayoshi , Tobe Yoshito 
Published: March 2017

AbstractA dehydrobenzo[12]annulene attached by three platinum catecholate units is oxidized chemically or electrochemically to generate mono‐, di‐, and trications. Similarly, a platinum catecholate complex with a dibenzo[8]annulene framework also generates mono‐ and dications upon oxidation. On the basis of theoretical and spectroscopic studies with respect to energetic, structural, and magnetic criteria, these dications are deduced to be aromatic, thus demonstrating a new method for stabilizing aromatic dications.
Efficient Electrocatalyst for the Hydrogen Evolution Reaction Derived from Polyoxotungstate/Polypyrrole/Graphene
Authors: Wang Xiao‐Li , Tang Yu‐Jia , Huang Wei , Liu Chun‐Hui , Dong Long‐Zhang , Li Shun‐Li , Lan Ya‐Qian 
Published: March 2017

AbstractEfficient hydrogen evolution reaction (HER) from water by electrocatalysis using cost‐effective materials is critical to realize the clean hydrogen production. Herein, with controlling the structure and composition of polyoxotungstate/conductive polypyrrole/graphene (PCG) precursor precisely and followed by a temperature‐programmed reaction, we developed a highly active and stable catalyst: NC@WxC/NRGO (NC: nitrogen‐doped porous carbon, NRGO: nitrogen‐doped reduced graphene oxide). The composite presents splendid performance towards HER in acidic media, with a small onset overpotential of 24 mV versus RHE (reversible hydrogen electrode), a low Tafel slope of 58.4 mV dec−1, a low overpotential of 100 mV at 10 mA cm−2, and remarkable long‐term cycle stability. This is one of the highest HER catalysts among the tungsten carbide‐based materials ever reported.
Pd‐Metalated Conjugated Nanoporous Polycarbazoles for Additive‐Free Cyanation of Aryl Halides: Boosting Catalytic Efficiency through Spatial Modulation
Authors: Ding Shunmin , Tian Chengcheng , Zhu Xiang , Abney Carter W. , Tian Ziqi , Chen Bo , Li Meijun , Jiang De‐en , Zhang Ning , Dai Sheng 
Published: March 2017

AbstractTransition‐metal‐catalyzed cyanation of aryl halides is a common route to benzonitriles, which are integral to many industrial procedures. However, traditional homogeneous catalysts for such processes are expensive and suffer poor recyclability, so a heterogeneous analogue is highly desired. A novel spatial modulation approach has been developed to fabricate a heterogeneous Pd‐metalated nanoporous polymer, which catalyzes the cyanation of aryl halides without need for ligands. The catalyst displays high activity in the synthesis of benzonitriles, including high product yields, excellent stability and recycling, and broad functional‐group tolerance.
Designing Highly Efficient CuI Photosensitizers for Photocatalytic H2 Evolution from Water
Authors: Kim Jaekwan , Whang Dong Ryeol , Park Soo Young 
Published: March 2017

AbstractA series of CuI photosensitizers was synthesized, characterized, and investigated for photocatalytic H2 evolution from water. A structure–property correlation was established for their catalytic activity and photophysical properties, which was further elaborated by DFT calculations. A new CuI photosensitizer (Cu‐TPAPhen) with triphenylamine‐substituted phenanthroline ligands showed unprecedentedly high turnover numbers of 19 000 when tested in combination with triethylamine as a sacrificial reagent and colloidal Pt as a H2 evolution catalyst. This work paves the way toward cheap metal‐based photosensitizers which can replace noble‐metal complexes in photocatalytic systems.
Analytical multi‐parametric stability boundaries of DC‐DC buck converters under V1 control concept
Authors: El Aroudi A. , Garcia G. , Al Hosani K. , Al Sayari N. , Al‐Numay M. 
Published: March 2017

SummaryTwo main methods for controlling switching converters exist in the literature. The direct one is the voltage mode control, which suffers from some disadvantages such as slow response to load variations and an input voltage‐dependent total loop gain. The current mode control can overcome these problems but at the expense of extra cost and more complex control design. V1 concept is a new promising control technique for designing voltage mode control of buck‐type converters with an optimal response similar to current mode control. In this paper, the dynamics and the stability of buck converters under V1 control are studied. In particular, subharmonic oscillation limits in the parameter space are addressed. First, a closed‐loop state‐space model is derived and then used to formulate an analytical matrix‐form expression for predicting the stability limit of the system. Using this expression, multi‐parametric stability boundaries are obtained. It is shown that the equivalent series inductance of the output capacitor can narrow the stability region. It is also demonstrated that the integral action in the feedback loop of a V1‐controlled buck converter has a negligible effect on the subharmonic oscillation boundary. The theoretical analysis is validated through numerical simulation of the circuit‐level switched model of the system. Copyright © 2017 John Wiley & Sons, Ltd.
The relationship between eating psychopathology and obstructive sleep apnea in bariatric surgery candidates: A retrospective study
Authors: Sockalingam Sanjeev , Tehrani Hedieh , Taube‐Schiff Marlene , Van Exan Jessica , Santiago Vincent , Hawa Raed 
Published: March 2017

AbstractObjectiveObstructive sleep apnea (OSA), eating psychopathology, and major depressive disorder (MDD) are highly prevalent in patients with severe obesity. Our study aimed to identify differences in binge‐eating disorder (BED) prevalence in bariatric surgery candidates with and without OSA.MethodsIn this retrospective study, demographic data, psychiatric diagnoses, OSA diagnosis, binge eating, depressive and quality of life (QOL) symptoms were collected from 1,099 bariatric surgery candidates from a Canadian setting. Analysis of variance was used to identify differences in psychopathology and QOL between groups with OSA and BED, BED alone, OSA alone or neither BED or OSA.ResultsStudy participants’ mean body mass index was 49.3 kg/m2 and 52.6% had a diagnosis of OSA. Patients with OSA were significantly more likely to have a diagnosis of past BED (χ2 = 6.848, p = .009) and current MDD (χ2 = 5.165, p = .023). Binge‐eating (p < .001) and depressive symptoms (p < .001) were significantly higher in patients with co‐morbid BED and OSA compared to patients with OSA alone or patients with no diagnosis of BED or OSA. Patients with co‐morbid BED and OSA only had significantly lower physical (p < .001) and mental QOL (p = .007) compared to patients with no diagnosis of BED or OSA.DiscussionOur findings suggest that patients with a history of BED should be reassessed for OSA. Research is needed to examine whether BED may predispose individuals to developing obesity and OSA.
The partial dopamine D2 receptor agonist aripiprazole is associated with weight gain in adolescent anorexia nervosa
Authors: Frank Guido K. W. , Shott Megan E. , Hagman Jennifer O. , Schiel Marissa A. , DeGuzman Marisa C. , Rossi Brogan 
Published: March 2017

AbstractObjectiveFinding medication to support treatment of anorexia nervosa has been difficult. Neuroscience‐based approaches may help in this effort. Recent brain imaging studies in adults and adolescents with anorexia nervosa suggest that dopamine‐related reward circuits are hypersensitive and could provide a treatment target.MethodsHere, we present a retrospective chart review of 106 adolescents with anorexia nervosa some of whom were treated with the dopamine D2 receptor partial agonist aripiprazole during treatment in a specialized eating disorder program.ResultsThe results show that aripiprazole treatment was associated with greater increase in body mass index (BMI) during treatment.DiscussionThe use of dopamine receptor agonists may support treatment success in anorexia nervosa and should be further investigated.
Does thinning‐induced gap size result in altered soil microbial community in pine plantation in eastern Tibetan Plateau?
Authors: Yang Bing , Pang Xueyong , Hu Bin , Bao Weikai , Tian Guanglong 
Published: March 2017

AbstractAlthough the effects of gap formation resulting from thinning on microclimate, plant generation and understory plant community have been well documented, the impact of thinning on soil microbial community and related ecological functions of forests particularly in subalpine coniferous region is largely unknown. Here, the effects of thinning on soil microbial abundance and community structure using phospholipid fatty acid (PLFA) in pine plantations were investigated 6 years after thinning. The experimental treatments consisted of two distinct‐sized gaps (30 m2 or 80 m2 in size) resulting from thinning, with closed canopy (free of thinning) as control. Soil temperature as well as the biomass of actinomycete and unspecific bacteria was sensitive to gap formation, but all these variables were only responsive to medium gap. Nonmetric multidimensional scaling confirmed that soil microbial community was responsive to gap size. In addition, gap size exerted contrasting effect on bacteria‐feeding nematode and fungi‐feeding nematodes. In conclusion, thinning‐induced gap size would affect soil microbial community through changing soil temperature or the abundance of fungi‐feeding nematodes.
Time vs. distance: Alternate metrics of animal resource selection provide opposing inference
Authors: Serrouya Robert , Kellner Amanda , Pavan Gary , Lewis Doug W. , DeMars Craig A. , McLellan Bruce N. 
Published: March 2017

AbstractQuantifying resource use or selection by valued species on a human‐altered landscape is important for wise conservation action. Here, we contrast metrics of resource selection based on Global Positioning System (GPS) telemetry, which indexes time spent in various habitats, with tracking in snow, which measures distance travelled. When animals move at different speeds within different habitats, the two methods can produce different results. The study was conducted in winter on endangered mountain caribou (Rangifer tarandus caribou) in a landscape fragmented by forestry roads and cutblocks. From 2001 to 2009, 25 caribou were monitored with GPS collars obtaining locations every two to six hours, and compared to 63 caribou trails followed in snow in the same study area and time period. Logistic regression was used to estimate selection for both metrics, with the same definition of use and availability employed. Forest age, tree species, edge distances, and road densities were the covariates of interest. For most covariates, the two metrics produced similar results that agreed with the literature: selection for primary forest stands that represent forage patches. Both metrics indicated selection for habitat edges that potentially enhance foraging. The distance metric (snow trailing) indicated strong selection for forestry roads (42% more than available), whereas GPS locations suggested an avoidance of roads (33% less than available). The GPS analysis was in agreement with the vast majority of work published on woodland caribou, whereas the distance metric suggests some of the first evidence of selection for anthropogenic linear features. Our results highlight a potential bias against detecting selection for habitat features used for movement when using long fix intervals (>2 h) that typify most GPS studies. Avoidance of linear features should be carefully examined and designs considered to asses this bias. Finally, the selection of roads by caribou exacerbates an already desperate situation by creating a potential trap because roads are also preferred by some predators.
ACE inhibitor‐associated intestinal angioedema in orthotopic heart transplantation
Authors: Srinivasan Dushyanth , Strohbehn Garth W. , Cascino Thomas 
Published: March 2017

AbstractAngiotensin‐converting enzyme inhibitor induced angioedema commonly involves the head and neck area. We report a case of angiotensin‐converting enzyme inhibitor induced intestinal angioedema in a heart transplant recipient on mTOR immunosuppression. A 36‐year‐old Caucasian woman with history of heart transplantation on sirolimus, tacrolimus and prednisone presented to the Emergency Department with abdominal pain, one day following lisinopril initiation. A computer tomography scan demonstrated diffuse bowel wall thickening consistent with pancolitis and edema. She was subsequently diagnosed with angiotensin‐converting enzyme inhibitor induced angioedema. Patients on mTOR immunosuppression are at higher risk for this potentially life‐threatening side effect. Knowledge of this interaction is critical for providers prescribing mTOR agents.
Design of flavonoid microparticles with channel forming properties to improve oxidative stability of sunflower oil
Authors: Morelo Guibeth , Márquez‐Ruiz Gloria , Holgado Francisca , Giménez Begoña , Robert Paz 
Published: March 2017

Quercetin (Q) and epicatechin (E) microparticles were designed using an oil‐insoluble polymer (inulin [In]) as encapsulating agent and with or without an oil‐soluble polymer (soy protein isolate [SPI]) by spray‐drying. Encapsulation efficiencies were significantly higher for the E systems than for Q systems, suggesting that the spatial arrangement may affect the hydroxyl groups availability to form hydrogen bonds. The microencapsulated flavonoids were added to sunflower oil (SO) in order to evaluate its oxidative stability. The induction period (IP) of SO, determined in Rancimat at 60°C, significantly increased when Q‐microparticles with or without SPI were added, showing those with SPI the highest IP value. In the case of E systems, the IP of SO increased only when E–In microparticles with SPI were added. These results suggest that SPI may favor the diffusion of flavonoids to the lipid medium by the formation of channels into the microparticles. The channels formation was observed for Q–In–SPI and E–In–SPI by a confocal laser scanning microscopy study. Additional oxidation studies under conditions of lower oxygen availability resulted in overall more retarded oxidation and no clear effect of SPI incorporation was observed.Practical application: The results show that it is possible to design flavonoid microparticles with antioxidant activity in bulk oils. The inclusion of a lipid‐soluble polymer such as soy protein isolate in the microparticles favors the flavonoid release from the microparticles to bulk oil by channel formation.Epicatechin (E) and quercetin (Q) microparticles designed with inulin (IN, encapsulating agent) and soy protein isolate (SPI, channelizing agent) are incorporated to sunflower oil (SO). The channels formation is observed for Q–In–SPI and E–In–SPI by confocal laser scanning microscopy. The induction period (IP) of SO (Rancimat at 60°C) significantly increases when Q‐microparticles with or without SPI are added, showing those with SPI the highest IP value. Regarding E systems, the IP of SO increases only when E–In microparticles with SPI are added. No clear effect of SPI incorporation is observed in additional oxidation studies under conditions of lower oxygen availability.
Silicon Nitride Capacitive Chemical Sensor for Phosphate Ion Detection Based on Copper Phthalocyanine – Acrylate‐polymer
Authors: Barhoumi Lassaad , Baraket Abdoullatif , Nooredeen Naglaa Mohammed , Ali Mounir Ben , Abbas Mohammed Nooredeen , Bausells Joan , Errachid Abdelhamid 
Published: March 2017

AbstractIn this work, we report the development of a highly sensitive capacitance chemical sensor based on a copper C,C,C,C‐tetra‐carboxylic phthalocyanine‐acrylate polymer adduct (Cu(II)TCPc‐PAA) for phosphate ions detection. A capacitance silicon nitride substrate based Al−Cu/Si‐p/SiO2/Si3N4 structure was used as transducer. These materials have provided good stability of electrochemical measurements. The functionalized silicon‐based transducers with a Cu(II)Pc‐PAA membrane were characterized by using Mott‐Schottky technique measurements at different frequency ranges and for different phosphate concentrations. The morphological surface of the Cu(II)Pc‐PAA modified silicon‐nitride based transducer was characterized by contact angle measurements and atomic force microscopy. The pH effect was also investigated by the Mott‐Schottcky technique for different Tris‐HCl buffer solutions. The sensitivity of silicon nitride was studied at different pH of Tris‐HCl buffer solutions. This pH test has provided a sensitivity value of 51 mV/decade. The developed chemical sensor showed a good performance for phosphate ions detection within the range of 10−10 to 10−5 M with a Nernstian sensitivity of 27.7 mV/decade. The limit of detection of phosphate ions was determined at 1 nM. This chemical sensor was highly specific for phosphate ions when compared to other interfering ions as chloride, sulfate, carbonate and perchlorate. The present capacitive chemical sensor is thus very promising for sensitive and rapid detection of phosphate in environmental applications.
Collapse risk of controlled rocking steel braced frames with different post‐tensioning and energy dissipation designs
Authors: Steele Taylor C. , Wiebe Lydell D. A. 
Published: March 2017

SummaryControlled rocking steel braced frames (CRSBFs) are low‐damage self‐centring lateral force resisting systems. Previous studies have shown that designing the energy dissipation (ED) and post‐tensioning (PT) in CRSBFs using a response modification factor of R=8 can prevent collapse of structures during earthquakes beyond the design level. However, designers have unique control over the hysteretic behaviour of the system, even after the response modification factor is selected. Additionally, recent studies have suggested that CRSBFs could also be designed using R>8 while still satisfying performance limits. This paper examines how the response modification factor and the design of the ED and PT influence the collapse performance of CRSBFs with three and six storeys where collapse occurs because of over‐rotation of the base rocking joint. In addition, the influence of using an additional rocking joint above the base to mitigate higher‐mode forces is evaluated for a 12‐storey frame. A total of 18 different designs are considered for the three buildings using different ED and PT design parameters, including different response modification factors. A suite of 44 ground motions is scaled until at least 50% of the records cause collapse, and fragility curves are generated using the truncated incremental dynamic analysis curves. The results from two different assessment methodologies show that the parameters selected have a marked influence on the collapse performance of a CRSBF. Nevertheless, even CRSBFs designed using R>8 or without supplemental ED can have acceptably low probabilities of collapse, provided that the frame members are designed to remain elastic. Copyright © 2017 John Wiley & Sons, Ltd.