bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulating the dependence of seismo-ionospheric coupling on the magnetic field inclination
Authors: Joshi Lalit Mohan , Sripathi Samireddipelle , Kumar Muppidi Ravi , Kherani Esfhan Alam 
Published: January 2018

Abstract. Infrasound generated during a seismic event upon reaching the ionospheric
heights possesses the ability to perturb the ionosphere. Detailed modelling
investigation considering 1-D dissipative linear dynamics, however, indicates
that the magnitude of ionospheric perturbation strongly depends on the
magnetic field inclination. Physics-based SAMI2 model codes have been
utilized to simulate the ionosphere perturbations that are generated due to
the action of the vertical wind perturbations associated with the seismic
infrasound. The propagation of the seismic energy and the vertical wind
perturbations associated with the infrasound in the model has been considered
to be symmetric about the epicentre in the north–south directions.
Ionospheric response to the infrasound wind, however, has been highly
asymmetric in the model simulation in the north–south directions. This
strong asymmetry is related to the variation in the inclination of the
Earth's magnetic field north and south of the epicentre. Ionospheric
monitoring generally provides an efficient tool to infer the crustal
propagation of the seismic energy. However, the results presented in this
paper indicate that the mapping between the crustal process and the
ionospheric response is not a linear one. These results also imply that the
lithospheric behaviour during a seismic event over a wide zone in low
latitudes can be estimated through ionospheric imaging only after factoring
in the magnetic field geometry. Keywords. Atmospheric composition and structure (pressure, density, and temperature) – history of geophysics (atmospheric sciences) – ionosphere (ionosphere–atmosphere interactions)
Large dendrinids meet giant clam: the bioerosion trace fossil &lt;i&gt;Neodendrina carnelia&lt;/i&gt; igen. et isp. n. in a &lt;i&gt;Tridacna&lt;/i&gt; shell from Pleistocene–Holocene coral reef deposits, Red Sea, Egypt
Authors: Wisshak Max , Neumann Christian 
Published: January 2018

Abstract. The rosette-shaped microboring trace fossil Neodendrina carnelia igen. et isp. n. – a large representative of the ichnofamily Dendrinidae – is identified on the inner side of the giant clam Tridacna maxima from Pleistocene to Holocene coral reef deposits of the El Quseir district at the Egyptian Red Sea coast. The new dendritic bioerosion trace fossil is diagnosed as a radial rosette comprised of a prostrate system of roofless canals that ramify in a strictly dichotomous fashion forming intermittent branches of uniform width and rounded terminations. The trace appears to be rare, although in the type material it occurs in a cluster of more than a hundred specimens. The location of traces on the interior surface of the shell suggests that boring occurred post-mortem to the host. Its record is presently restricted to shallow marine, euphotic, tropical coral reef settings in the Western Indo-Pacific (Red Sea and Madagascar). The biological identity of the trace maker cannot be resolved yet, but several lines of reasoning allow speculations directed towards a complex attachment scar, perhaps produced by a benthic foraminiferan or a macrophyte.
Encontrabilidade da Informação no ambiente Technology, Entertainment and Design
Authors: Silva Nathália Britto Pinheiro da , Vechiato Fernando Luiz , Vidotti Silvana Aparecida Borsetti Gregorio 
Published: January 2018

Introdução: A disseminação e o compartilhamento da informação e conhecimento são o principal objetivo dos ambientes informacionais digitais, como a organização Technology, Entertainment and Design (TED), que tem o propósito de divulgar as palestras que são gravadas, as quais abordam diversos assuntos em formato de vídeo digital. Considerando a relevância desse ambiente, torna-se importante refletir a respeito da Encontrabilidade da Informação disponível, com a intenção de compreender se a sua Arquitetura da Informação contempla atributos que facilitam a localização, o acesso, o uso e a apropriação da informação pelos usuários. Objetivo: Assim, os objetivos desta pesquisa foram avaliar a Encontrabilidade da Informação no ambiente informacional digital TED a partir dos seus atributos e analisar os resultados à luz das dimensões da Arquitetura da Informação, os quais são o conteúdo, o contexto e o usuário. Metodologia: Trata-se de uma pesquisa documental e exploratória, com abordagem qualitativa e com a utilização de observação participante. Resultados: Os resultados revelam que os atributos de Encontrabilidade da Informação presentes no TED indicam consonância com a missão organizacional e proporcionam a interação do sujeito informacional com a interface. Conclusões: A ausência de alguns atributos pode comprometer a apropriação da informação pelos sujeitos informacionais.
Aplicación grupal del Protocolo Unificado para el tratamiento transdiagnóstico de los trastornos emocionales en población argentina
Authors: Grill Silvina S. , Castañeiras Claudia Elena , Fasciglione M. Paola 
Published: January 2018

Abstract: Group application of the Unified Protocol for transdiagnostic treatment of emotional disorders in an Argentine population. The aim of this non-control trial was to analyze the effectiveness of Barlow's Unified Protocol (2011) group application in adult patients with emotional disorders of the anxious-depressive spectrum. This trial study was based on a no-control-group design that included pre- and post-treatment measures. The intervention was performed with 23 patients who met diagnostic criteria for panic attack, agoraphobia, social phobia, generalized anxiety disorder, unspecified anxiety disorder and major depression and attended an average of 14 sessions. The results showed a significant reduction in symptoms of anxiety and depression, and of the difficulties in the emotional regulation in the patients, also an increase of positive emotions, personal strength and functional improvement. These data provide evidence on the effectiveness of the transdiagnostic approach for emotional disorders in Argentina.Resumen: El objetivo de este ensayo no controlado fue analizar la efectividad de la aplicación en formato grupal del Protocolo Unificado de Barlow et al. (2011) a pacientes adultos con trastornos emocionales del espectro ansioso-depresivo. Este ensayo clínico se basó en un diseño sin grupo control que incluyó medidas pre y post-tratamiento. La intervención se realizó con 23 pacientes que cumplieron criterios diagnósticos de diversos trastornos incluyendo ataque de pánico, agorafobia, fobia social, trastorno de ansiedad generalizada, trastorno de ansiedad no especificado y depresión mayor y que asistieron a un promedio de 14 sesiones. Los resultados mostraron una reducción significativa de los síntomas de ansiedad y depresión y de las dificultades en la regulación emocional en los pacientes así como un aumento de las emociones positivas, la fortaleza personal y mejoría funcional. Estos datos aportan evidencia sobre la efectividad del abordaje transdiagnóstico para trastornos emocionales en Argentina.
Evidence-based design and evaluation of a whole genome sequencing clinical report for the reference microbiology laboratory
Authors: Crisan Anamaria , McKee Geoffrey , Munzner Tamara , Gardy Jennifer L. 
Published: January 2018

Background
Microbial genome sequencing is now being routinely used in many clinical and public health laboratories. Understanding how to report complex genomic test results to stakeholders who may have varying familiarity with genomics—including clinicians, laboratorians, epidemiologists, and researchers—is critical to the successful and sustainable implementation of this new technology; however, there are no evidence-based guidelines for designing such a report in the pathogen genomics domain. Here, we describe an iterative, human-centered approach to creating a report template for communicating tuberculosis (TB) genomic test results.

Methods
We used Design Study Methodology—a human centered approach drawn from the information visualization domain—to redesign an existing clinical report. We used expert consults and an online questionnaire to discover various stakeholders’ needs around the types of data and tasks related to TB that they encounter in their daily workflow. We also evaluated their perceptions of and familiarity with genomic data, as well as its utility at various clinical decision points. These data shaped the design of multiple prototype reports that were compared against the existing report through a second online survey, with the resulting qualitative and quantitative data informing the final, redesigned, report.

Results
We recruited 78 participants, 65 of whom were clinicians, nurses, laboratorians, researchers, and epidemiologists involved in TB diagnosis, treatment, and/or surveillance. Our first survey indicated that participants were largely enthusiastic about genomic data, with the majority agreeing on its utility for certain TB diagnosis and treatment tasks and many reporting some confidence in their ability to interpret this type of data (between 58.8% and 94.1%, depending on the specific data type). When we compared our four prototype reports against the existing design, we found that for the majority (86.7%) of design comparisons, participants preferred the alternative prototype designs over the existing version, and that both clinicians and non-clinicians expressed similar design preferences. Participants showed clearer design preferences when asked to compare individual design elements versus entire reports. Both the quantitative and qualitative data informed the design of a revised report, available online as a LaTeX template.

Conclusions
We show how a human-centered design approach integrating quantitative and qualitative feedback can be used to design an alternative report for representing complex microbial genomic data. We suggest experimental and design guidelines to inform future design studies in the bioinformatics and microbial genomics domains, and suggest that this type of mixed-methods study is important to facilitate the successful translation of pathogen genomics in the clinic, not only for clinical reports but also more complex bioinformatics data visualization software.
A novel enediyne‐integrated antibody–drug conjugate shows promising antitumor efficacy against CD30+ lymphomas
Authors: Wang Rong , Li Liang , Zhang Shenghua , Li Yi , Wang Xiaofei , Miao Qingfang , Zhen Yongsu 
Published: January 2018

CD30 is a 120‐kDa type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. Overexpression of CD30 has been reported in Hodgkin's lymphoma (HL) and anaplastic large‐cell lymphoma (ALCL). CD30‐targeted treatment with antibody–drug conjugates (ADCs) can lead to promising clinical benefit. Lidamycin (LDM), consisting of an apoprotein LDP and an active enediyne chromophore AE, is a member of the enediyne antibiotic family and one of the most potent antitumor agents. AE and LDP can be dissociated and reconstituted under certain conditions in vitro. LDM is an ideal payload for the preparation of ADCs. In this study, we show the generation, production, and antitumor activity of anti‐CD30‐LDM, a novel ADC which consists of the intact anti‐CD30 antibody and LDM. First, the anti‐CD30‐LDP fusion protein was constructed and expressed in CHO/dhFr− cells. Anti‐CD30‐LDP showed specific and high‐affinity binding to CD30 and could be internalized into target cells. It also exhibited excellent tumor‐targeting capability in vivo. Next, anti‐CD30‐LDM was prepared by assembling the enediyne molecule AE to the fusion protein anti‐CD30‐LDP. Anti‐CD30‐LDM was highly cytotoxic to HL and ALCL cell lines, with IC50 values of 5–50 pm. It can also induce cell apoptosis and G2/M cell cycle arrest. In the Karpas299 xenograft model, the tumor growth was inhibited by 87.76% in mice treated with anti‐CD30‐LDM and with no discernible adverse effects. Taken together, anti‐CD30‐LDM shows attractive tumor‐targeting capability and antitumor efficacy both in vitro and in vivo and could be a promising candidate for the treatment of CD30+ lymphomas.
Characterization of a FOXG1:TLE1 transcriptional network in glioblastoma‐initiating cells
Authors: Dali Rola , Verginelli Federica , Pramatarova Albena , Sladek Robert , Stifani Stefano 
Published: January 2018

Glioblastoma (GBM) is the most common and deadly malignant brain cancer of glial cell origin, with a median patient survival of less than 20 months. Transcription factors FOXG1 and TLE1 promote GBM propagation by supporting maintenance of brain tumour‐initiating cells (BTICs) with stem‐like properties. Here, we characterize FOXG1 and TLE1 target genes in GBM patient‐derived BTICs using ChIP‐Seq and RNA‐Seq approaches. These studies identify 150 direct FOXG1 targets, several of which are also TLE1 targets, involved in cell proliferation, differentiation, survival, chemotaxis and angiogenesis. Negative regulators of NOTCH signalling, including CHAC1, are among the transcriptional repression targets of FOXG1:TLE1 complexes, suggesting a crosstalk between FOXG1:TLE1 and NOTCH‐mediated pathways in GBM. These results provide previously unavailable insight into the transcriptional programs underlying the tumour‐promoting functions of FOXG1:TLE1 in GBM.
Quantifying the Limitation to World Cereal Production Due To Soil Phosphorus Status
Authors: Kvakić Marko , Pellerin Sylvain , Ciais Philippe , Achat David L. , Augusto Laurent , Denoroy Pascal , Gerber James S. , Goll Daniel , Mollier Alain , Mueller Nathaniel D. , Wang Xuhui , Ringeval Bruno 
Published: January 2018

AbstractPhosphorus (P) is an essential element for plant growth. Low P availability in soils is likely to limit crop yields in many parts of the world, but this effect has never been quantified at the global scale by process‐based models. Here we attempt to estimate P limitation in three major cereals worldwide for the year 2000 by combining information on soil P distribution in croplands and a generic crop model, while accounting for the nature of soil‐plant P transport. As a global average, the diffusion‐limited soil P supply meets the crop's P demand corresponding to the climatic yield potential, due to the legacy soil P in highly fertilized areas. However, when focusing on the spatial distribution of P supply versus demand, we found strong limitation in regions like North and South America, Africa, and Eastern Europe. Averaged over grid cells where P supply is lower than demand, the global yield gap due to soil P is estimated at 22, 55, and 26% in winter wheat, maize, and rice. Assuming that a fraction (20%) of the annual P applied in fertilizers is directly available to the plant, the global P yield gap lowers by only 5–10%, underlying the importance of the existing soil P supply in sustaining crop yields. The study offers a base for exploring P limitation in crops worldwide but with certain limitations remaining. These could be better accounted for by describing the agricultural P cycle with a fully coupled and mechanistic soil‐crop model.
Crystallization and Disturbance Histories of Single Zircon Crystals From Hadean‐Eoarchean Acasta Gneisses Examined by LA‐ICP‐MS U‐Pb Traverses
Authors: Guitreau Martin , Mora Nicolas , Paquette Jean‐Louis 
Published: January 2018

AbstractZircon U‐Pb geochronology is a very robust dating method but the accuracy of determined ages can sometimes be compromised. This is because, as commonly observed, the U‐Pb isotope system can be reopened during the post‐crystallization evolution of a zircon. The present manuscript investigates the capability of traverses by LA‐ICP‐MS to identify zones of well‐preserved U‐Pb isotope systematics within zircon crystals. The data for the different zones can be used to construct internal Discordia lines that provide age information about crystallization and metamorphism of single zircon crystals. To test our approach, we analyzed zircons from three ca. 3.96 Ga Acasta gneisses. Results demonstrate that such a method allows retrieval of original crystallization age in most of the studied zircons, even in those that experienced ancient U‐Pb disturbances resulting in discordant U‐Pb data. It was also possible to estimate disturbance ages, though not as precisely as for the igneous crystallization, in many of the studied crystals.
Relativistic Electron Microburst Events: Modeling the Atmospheric Impact
Authors: Seppälä A. , Douma E. , Rodger C. J. , Verronen P. T. , Clilverd M. A. , Bortnik J. 
Published: January 2018

AbstractRelativistic electron microbursts are short‐duration, high‐energy precipitation events that are an important loss mechanism for radiation belt particles. Previous work to estimate their atmospheric impacts found no significant changes in atmospheric chemistry. Recent research on microbursts revealed that both the fluxes and frequency of microbursts are much higher than previously thought. We test the seasonal range of atmospheric impacts using this latest microburst information as input forcing to the Sodankylä Ion and Neutral Chemistry model. A modeled 6 h microburst storm increased mesospheric HOx by 15–25%/800–1,200% (summer/winter) and NOx by 1,500–2,250%/80–120%. Together, these drive 7–12%/12–20% upper mesospheric ozone losses, with a further 10–12% longer‐term middle mesospheric loss during winter. Our results suggest that existing electron precipitation proxies, which do not yet take relativistic microburst energies into account, are likely missing a significant source of precipitation that contributes to atmospheric ozone balance.
Tailoring Meridional and Seasonal Radiative Forcing by Sulfate Aerosol Solar Geoengineering
Authors: Dai Z. , Weisenstein D. K. , Keith D. W. 
Published: January 2018

AbstractWe study the possibility of designing solar radiation management schemes to achieve a desired meridional radiative forcing (RF) profile using a two‐dimensional chemistry‐transport‐aerosol model. Varying SO2 or H2SO4 injection latitude, altitude, and season, we compute RF response functions for a broad range of possible injection schemes, finding that linear combinations of these injection cases can roughly achieve RF profiles that have been proposed to accomplish various climate objectives. Globally averaged RF normalized by the sulfur injection rate (the radiative efficacy) is largest for injections at high altitudes, near the equator, and using emission of H2SO4 vapor into an aircraft wake to produce accumulation‐mode particles. There is a trade‐off between radiative efficacy and control as temporal and spatial control is best achieved with injections at lower altitudes and higher latitudes. These results may inform studies using more realistic models that couple aerosol microphysics, chemistry, and stratospheric dynamics.
Urban Heat Island Over Delhi Punches Holes in Widespread Fog in the Indo‐Gangetic Plains
Authors: Gautam Ritesh , Singh Manoj K. 
Published: January 2018

AbstractPersistent and widespread fog affects several densely populated and agriculturally fertile basins around the world. Dense and polluted fog is especially known to impact transportation, air quality, and public health. Here we report a striking observation of holes in fog over urban areas in satellite imagery. The extent of fog holes appear highly correlated with city populations in fog‐prevalent regions of Asia, Europe, and the United States. We find the highest frequency and largest extent of fog holes over Delhi along with suppressed fog fraction, amidst increased fog occurrence over the Indo‐Gangetic Plains, based on 17 years of satellite data (2000–2016). This apparent urban heat impact is characterized in sharp urban‐rural gradients in surface temperatures and fog thickness. Urban heating seems to have already amplified the long‐term fog decline in Europe and the United States and should be assessed over regions undergoing urban expansion including India, where no previous linkages are reported between urban heating and fog.
What Has Controlled the Poleward Migration of Annual Averaged Location of Tropical Cyclone Lifetime Maximum Intensity Over the Western North Pacific Since 1961?
Authors: Song Jinjie , Klotzbach Philip J. 
Published: January 2018

AbstractThe long‐term tendency of the average latitude at which tropical cyclones (TCs) reach their lifetime maximum intensity (LMI) over the western North Pacific (WNP) is investigated in this study. Despite the post‐1961 significant poleward shift in the annual mean LMI latitude, the migration rate is nonuniform on decadal timescales, having an insignificant trend and a significant increasing trend before and after 1980, respectively. Interdecadal fluctuations of TC genesis latitude (φG) as well as increases in latitudinal distance between genesis position and LMI location (Δφ) are both responsible for the observed LMI latitude trends. The former is linked to the Interdecadal Pacific Oscillation (IPO), which favors TCs forming in the northwestern (southeastern) quadrant of the WNP in negative (positive) IPO phases. The latter primarily results from the continuous warming of WNP sea surface temperature, which further increases the maximum potential intensity and extends the region favorable for TC development to higher latitudes.
Crustal Structure and Evolution of the Eastern Himalayan Plate Boundary System, Northeast India
Authors: Mitra S. , Priestley K. F. , Borah Kajaljyoti , Gaur V. K. 
Published: January 2018

AbstractWe use data from 24 broadband seismographs located south of the Eastern Himalayan plate boundary system to investigate the crustal structure beneath Northeast India. P wave receiver function analysis reveals felsic continental crust beneath the Brahmaputra Valley, Shillong Plateau and Mikir Hills, and mafic thinned passive margin transitional crust (basement layer) beneath the Bengal Basin. Within the continental crust, the central Shillong Plateau and Mikir Hills have the thinnest crust (30 ± 2 km) with similar velocity structure, suggesting a unified origin and uplift history. North of the plateau and Mikir Hills the crustal thickness increases sharply by 8–10 km and is modeled by ∼30∘ north dipping Moho flexure. South of the plateau, across the ∼1 km topographic relief of the Dawki Fault, the crustal thickness increases abruptly by 12–13 km and is modeled by downfaulting of the plateau crust, overlain by 13–14 km thick sedimentary layer/rocks of the Bengal Basin. Farther south, beneath central Bengal Basin, the basement layer is thinner (20–22 km) and has higher Vs (∼4.1 km s−1) indicating a transitional crystalline crust, overlain by the thickest sedimentary layer/rocks (18–20 km). Our models suggest that the uplift of the Shillong Plateau occurred by thrust faulting on the reactivated Dawki Fault, a continent margin paleorift fault, and subsequent back thrusting on the south dipping Oldham Fault, in response to flexural loading of the Eastern Himalaya. Our estimated Dawki Fault offset combined with timing of surface uplift of the plateau reveals a reasonable match between long‐term uplift and convergence rate across the Dawki Fault with present‐day GPS velocities.