bluuebunny/crossref_metadata_2025_split huggingface dataset:
Almost Disturbance Decoupling for a Class of Nonlinear Systems Subject to Time‐Delays Via Sampled‐Data Output Feedback Control
Authors: Meng Qinghua , Wang Pan , Sun Zong‐Yao , Chen Chih‐Chiang 
Published: June 2017

AbstractThis paper considers the problem of almost disturbance decoupling (ADD) via sampled‐data output feedback control for a class of uncertain nonlinear systems subject to time‐delays. Based on output feedback domination approach, a sampled‐data output feedback controller is designed to globally stabilize the system under a lower‐triangular linear growth condition. Gronwall‐Bellman‐like inequality and inductive method are introduced to estimate the state growth in the presence of time‐delays, uncertain nonlinearities and unknown disturbances. The proposed controller can attenuate the influence of disturbances on the output to an arbitrary degree in the L2 gain sense. Finally, simulation results show the effectiveness of the control method.
Biosynthesis of novel 7,8‐dihydroxyflavone glycoside derivatives and in silico study of their effects on BACE1 inhibition
Authors: Pandey Ramesh Prasad , Parajuli Prakash , Pokhrel Anaya Raj , Sohng Jae Kyung 
Published: June 2017

Abstract7,8‐Dihydroxyflavone (7,8‐DHF) has been conjugated with glucose moiety to produce glucoside derivatives. Three analogues of 7,8‐DHF (7‐O‐β‐d‐glucosyl‐8‐hydroxyflavone, 7‐hydroxy‐8‐O‐β‐d‐glucosyl flavone, and 7,8‐di‐O‐β‐d‐glucosylflavone) have been successfully produced from in vitro reaction using glycosyltransferase of Bacillus licheniformis. Production of these 7,8‐DHF derivatives were shifted to cheaper and easier approach in this study by using engineered Escherichia coli BL21 (DE3) ΔpgiΔzwfΔushA cells in which the flow of glucose‐6‐phospahte toward glycolysis and pentose phosphate pathway and hydrolysis of UDP‐α‐d‐glucose were blocked while directing the carbon flux toward UDP‐α‐d‐glucose by overexpressing UDP‐α‐d‐glucose pathway genes. Supplementation of 300 μM of 7,8‐DHF to the culture resulted in production of 171 μM of 7‐O‐β‐d‐glucosyl‐8‐hydroxyflavone, 68 μM of 7‐hydroxy‐8‐O‐β‐d‐glucoxyflavone, and 55 μM of 7,8‐di‐O‐β‐d‐glucoxyflavone in laboratory‐scale 3‐L fermentor, representing 98% bioconversion of initially fed substrate to respective glucoside derivatives within 48 H. These products were characterized by high‐performance liquid chromatography‐photodiode array (HPLC‐PDA), HPLC‐PDA‐quadruple time of flight‐electron spray ionization mass spectrometry, and nuclear magnetic resonance analyses. These newly synthesized derivatives were found to be able to interact with amino acids of active site of human β‐site amyloid precursor protein cleaving β‐site amyloid precursor protein cleaving enzyme 1 (BACE1) β‐secretase enzyme in in silico studies, thus displaying possible application in cure of Alzheimer's disease.
SGK1/Nedd4–2 signaling pathway regulates the activity of human organic anion transporters 3
Authors: Wang Haoxun , You Guofeng 
Published: June 2017

AbstractHuman organic anion transporter 3 (hOAT3) is localized at the basolateral membrane of renal proximal tubule cells and facilitates the renal secretion of numerous clinical drugs, including anti‐HIV therapeutics, anti‐tumor drugs, antibiotics, antihypertension drugs and anti‐inflammatories. The present study explored the role of serum and glucocorticoid‐inducible kinase 1 (sgk1) in the regulation of hOAT3. It was shown that over‐expression of sgk1 in hOAT3‐expressing cells stimulated hOAT3 transport activity by enhancing the transporter expression at the plasma membrane, kinetically reflected as an increased maximal transport velocity Vmax without substantial change in the substrate‐binding affinity Km. In contrast, treatment of cells with the sgk‐specific inhibitor GSK650394 resulted in a dose‐dependent inhibition of hOAT3 transport activity. Evidence was further provided that sgk1 regulation of hOAT3 activity was mediated by ubiquitin ligase Nedd4–2, an enzyme previously shown to have an inhibitory effect on hOAT3. It was shown that sgk1 phosphorylated Nedd4–2, weakened the association between Nedd4–2 and hOAT3, and decreased hOAT3 ubiquitination. Functionally, the sgk1‐stimulated hOAT3 transport activity was attenuated in the presence of a ligase‐dead mutant of Nedd4–2. In summary, the investigation established for the first time that sgk1 stimulates hOAT3 transport activity by interfering with the inhibitory effect of Nedd4–2 on the transporter.
Assessing Inter and Intra‐particle Heterogeneity in Alumina‐poor H‐ZSM‐5 Zeolites
Authors: Kennes Koen , Demaret Coralie , Van Loon Jordi , Kubarev Alexey V. , Fleury Guillaume , Sliwa Michel , Delpoux Olivier , Maury Sylvie , Harbuzaru Bogdan , Roeffaers Maarten B. J. 
Published: June 2017

AbstractWe reveal the presence of significant variations in Brønsted catalytic activity within and between individual H‐ZSM‐5 zeolite crystals. Fluorescence microscopy in combination with a fluorogenic probe was used to resolve the catalytic activity at the nanoscale. The observed variations in catalytic activity could be directly linked to structural parameters and crystal morphology observed in scanning electron microscopy and by specifically staining crystal defects. The obtained results are directly compared with ensemble averaged information from techniques such as pyridine IR spectroscopy and nitrogen physisorption, typically used to characterize acid zeolites. The inter‐ and intra‐particle heterogeneities resolved by the employed fluorescence approach remain unaddressed by bulk characterization. Our experimental results relate the heterogeneous catalytic activity to variation in both the Si/Al ratio and mesoporosity induced during the zeolite synthesis.
An Investigation of the Symmetric and Asymmetric Cleavage Products in the System Aluminum Trihalide/1‐Butylimidazole
Authors: Hog Michael , Schneider Marius , Studer Gauthier , Bäuerle Monika , Föhrenbacher Steffen A. , Scherer Harald , Krossing Ingo 
Published: June 2017

AbstractMixtures of AlX3 (X=Cl, Br) with 1‐butylimidazole (BuIm) in various ratios were investigated. The mixtures were characterized by multinuclear (1H, 27Al, 13C, and 15N) NMR, IR, and Raman spectroscopy and in part by single‐crystal X‐ray diffraction. Depending on the molar fraction x(AlBr3) of the AlBr3‐based mixtures, the cationic aluminum complexes [Al(BuIm)6]3+ and [AlBr2(BuIm)4]+, the neutral adduct [AlBr3(BuIm)], as well as the anions Br−, [AlBr4]−, and [Al2Br7]− could be identified as the products of the symmetric and asymmetric cleavage of dimeric Al2Br6. Furthermore, there are hints at the formation of [AlBr2(BuIm)2]+ or related cations. Comparison of the AlBr3/BuIm system with AlCl3‐based mixtures revealed the influence of the halide: In contrast to AlBr3, the trication [Al(BuIm)6]3+ could not be detected as main product in a 1:6 mixture of AlCl3 and BuIm. Additionally, [AlCl3(BuIm)] crystallizes from a mixture with x(AlCl3)=0.60 at room temperature, whereas the corresponding AlBr3‐based mixture remains liquid even at +6 °C. Three AlBr3‐based mixtures are liquid at room temperature, whereas all other mixtures are solids with melting points between 46 and 184 °C. The three liquid mixtures exhibit medium to high viscosities (117 to >1440 mPa s), low conductivities (0.03–0.20 mS cm−1), but high densities (1.80–2.21 g cm−3). Aluminum could be successfully deposited from one of the neat Lewis acidic mixtures of the AlBr3‐based system.
Ambient Water‐Stable Dianionic Electron Donors: Intramolecular Noncovalent Conduits Assist Charge Delocalization
Authors: Keshri Sudhir Kumar , Kumar Sharvan , Mandal Kalyanashis , Mukhopadhyay Pritam 
Published: June 2017

AbstractElectron‐rich π‐conjugated dianions are known to be ambient unstable and their stabilization in ambient water is yet to be realized. We report the first example of an exceptionally stable naphthalenediimide‐based dianion in ambient and hot water, forming one of the most stable redox‐active dianion. The half‐life (t1/2) of dianion (1 a2−) is more than four months in ambient water. The dianionic state was confirmed by X‐ray crystallography and by various spectroscopic methods. The noncovalent electronic conduits introduced for the first time in dianions, embrace nO→π*C≡N interactions and aid in delocalizing the dianionic charge as validated from theoretical studies. The dianions harness strong NIR absorption and electron donor ability to organic acceptors and metal ions, which make them suitable for potential green energy applications.
Interactions between Ketones and Alcohols: Rotational Spectrum and Internal Dynamics of the Acetone–Ethanol Complex
Authors: Gou Qian , Favero Laura B. , Feng Gang , Evangelisti Luca , Pérez Cristóbal , Caminati Walther 
Published: June 2017

AbstractThe rotational spectra of two isotopologues of the 1:1 complex formed between acetone and ethanol have been recorded and analyzed by using Fourier‐transform microwave spectroscopy. One rotamer was detected, in which ethanol adopts the gauche form. The two subunits are linked by a conventional O−H⋅⋅⋅O and a weak C−H⋅⋅⋅O hydrogen bond, forming a six‐membered ring. Each rotational transition is split into five component lines due to the internal rotations of two nonequivalent acetone methyl groups. The V3 barriers to internal rotation of the two CH3 tops of acetone were determined to be 252(4) and 220(1) cm−1, which are noticeably lower than the value for the monomer (266 cm−1).
Tuning the Porphyrin Building Block in Self‐Assembled Cages for Branched‐Selective Hydroformylation of Propene
Authors: Wang Xiaowu , Nurttila Sandra S. , Dzik Wojciech I. , Becker René , Rodgers Jody , Reek Joost N. H. 
Published: June 2017

AbstractUnprecedented regioselectivity to the branched aldehyde product in the hydroformylation of propene was attained on embedding a rhodium complex in supramolecular assembly L2, formed by coordination‐driven self‐assembly of tris(meta‐pyridyl)phosphine and zinc(II) porpholactone. The design of cage L2 is based on the ligand‐template approach, in which the ligand acts as a template for cage formation. Previously, first‐generation cage L1, in which zinc(II) porphyrin units were utilized instead of porpholactones, was reported. Binding studies demonstrate that the association constant for the formation of second‐generation cage L2 is nearly an order of magnitude higher than that of L1. This strengthened binding allows cage L2 to remain intact in polar and industrially relevant solvents. As a consequence, the unprecedented regioselectivity for branched aldehyde products can be maintained in polar and coordinating solvents by using the second‐generation assembly.
Reaction of Dihalodiboranes(4) with a N‐Heterocyclic Silylene: Facile Construction of 1‐Aryl‐2‐Silyl‐1,2‐Diboraindanes
Authors: Braunschweig Holger , Brückner Tobias , Deißenberger Andrea , Dewhurst Rian D. , Gackstatter Annika , Gärtner Annalena , Hofmann Alexander , Kupfer Thomas , Prieschl Dominic , Thiess Torsten , Wang Sunewang Rixin 
Published: June 2017

AbstractDihalodiboranes(4) react with a N‐heterocyclic silylene (NHSi) to generate NHSi adducts of 1‐aryl‐2‐silyl‐1,2‐diboraindanes, as was confirmed by X‐ray crystallography, featuring the functionalization of both B−X (X=halogen) bonds and a sp3‐ or sp2‐C−H bond under mild conditions. Coordination of a third NHSi to the proposed 1,1‐diaryl‐2,2‐disilyldiborane(4) intermediates, generated by a twofold B−X insertion, may be crucial for the C−H borylation that leads to the final products. Notably, our results demonstrate the first C−H borylation with a strong B−F bond activated by silylene insertion.
New chiral stationary phases based on xanthone derivatives for liquid chromatography
Authors: Fernandes Carla , Tiritan Maria Elizabeth , Cravo Sara , Phyo Ye’ Zaw , Kijjoa Anake , Silva Artur M.S. , Cass Quezia B. , Pinto Madalena M.M. 
Published: June 2017

AbstractSix chiral derivatives of xanthones (CDXs) were covalently bonded to silica, yielding the corresponding xanthonic chiral stationary phases (XCSPs). The new XCSPs were packed into stainless‐steel columns with 150 x 4.6 mm i.d. Moreover, the greening of the chromatographic analysis by reducing the internal diameter (150 x 2.1 mm i.d.) of the liquid chromatography (LC) columns was also investigated. The enantioselective capability of these phases was evaluated by LC using different chemical classes of chiral compounds, including several types of drugs. A library of CDXs was evaluated in order to explore the principle of reciprocity as well as the chiral self‐recognition phenomenon. The separation of enantiomeric mixtures of CDXs was investigated under multimodal elution conditions. The XCSPs provided high specificity for the enantiomeric mixtures of CDXs evaluated mainly under normal‐phase elution conditions. Furthermore, two XCSPs were prepared with both enantiomers of the same xanthonic selector in order to confirm the inversion order elution.
A GLOBAL WEAK FORM ELEMENT FREE METHOD FOR DIRECT CURRENT RESISTIVITY FORWARD SIMULATION
Authors: Chang‐Ying MA , Jian‐Xin LIU , Hai‐Fei LIU , Rong‐Wen GUO , Chuang‐Hua CAO 
Published: June 2017

AbstractWe present a global weak form element free method (EFM) for simulation of direct current resistivity. EFM is a new numerical simulation method developed on the basis of the finite element method (FEM). The key point of this method is the absence of elements and the nodes free from the elemental restraint, which makes it very flexible and simple in pre‐processing. It utilizes the nodes of local support domain to construct shape functions to achieve the accurate approximations of the local domain. Approximations of EFM are of high order and boundary conditions are enforced simply, because the radial point interpolation method (RPIM) is used to construct shape function. Therefore, EFM is more suitable to simulate complex models than FEM. First, the boundary value problem and the corresponding variational problem of direct current resistivity forward simulation are derived starting with the partial differential equation of current field. Second, the construction of RPIM shape function is introduced in details. Third, equations of the global weak form EFM for direct current resistivity are derived in details based on RPIM shape function. Then, a Fortran program is written according to the equations. By this program, a homogeneous half‐space model was used to verify our element free approach. At the same time, we compared the solutions of EFM and FEM in details which shows that the solutions of EFM are more accurate. Furthermore, the solutions indicate the correctness and effectiveness of the EFM for direct current resistivity forward simulation. Finally, we improve the simulation accuracy successfully by refining nodes arbitrarily, and the solutions of EFM forward simulation for complex geoelectric models show that EFM has a high degree of flexibility.
Assessment of programmed death‐ligand 1 expression and tumor‐associated immune cells in pediatric cancer tissues
Authors: Majzner Robbie G. , Simon Jason S. , Grosso Joseph F. , Martinez Daniel , Pawel Bruce R. , Santi Mariarita , Merchant Melinda S. , Geoerger Birgit , Hezam Imene , Marty Virginie , Vielh Phillippe , Daugaard Mads , Sorensen Poul H. , Mackall Crystal L. , Maris John M. 
Published: June 2017

BACKGROUNDProgrammed death 1 (PD‐1) signaling in the tumor microenvironment dampens immune responses to cancer, and blocking this axis induces antitumor effects in several malignancies. Clinical studies of PD‐1 blockade are only now being initiated in pediatric patients, and little is known regarding programmed death‐ligand 1 (PD‐L1) expression in common childhood cancers. The authors characterized PD‐L1 expression and tumor‐associated immune cells (TAICs) (lymphocytes and macrophages) in common pediatric cancers.METHODSWhole slide sections and tissue microarrays were evaluated by immunohistochemistry for PD‐L1 expression and for the presence of TAICs. TAICs were also screened for PD‐L1 expression.RESULTSThirty‐nine of 451 evaluable tumors (9%) expressed PD‐L1 in at least 1% of tumor cells. The highest frequency histotypes comprised Burkitt lymphoma (80%; 8 of 10 tumors), glioblastoma multiforme (36%; 5 of 14 tumors), and neuroblastoma (14%; 17 of 118 tumors). PD‐L1 staining was associated with inferior survival among patients with neuroblastoma (P = .004). Seventy‐four percent of tumors contained lymphocytes and/or macrophages. Macrophages were significantly more likely to be identified in PD‐L1–positive versus PD‐L1–negative tumors (P < .001).CONCLUSIONSA subset of diagnostic pediatric cancers exhibit PD‐L1 expression, whereas a much larger fraction demonstrates infiltration with tumor‐associated lymphocytes. PD‐L1 expression may be a biomarker for poor outcome in neuroblastoma. Further preclinical and clinical investigation will define the predictive nature of PD‐L1 expression in childhood cancers both at diagnosis and after exposure to chemoradiotherapy. Cancer 2017;123:3807–3815. © 2017 American Cancer Society
Exploiting DNA damage without repair: The activity of platinum chemotherapy in BRCA‐mutated prostate cancers
Authors: Humeniuk Michael S. , Zhang Tian , Armstrong Andrew J. 
Published: June 2017

The report in this issue by Pomerantz and colleagues demonstrates that men with metastatic prostate cancer harboring germline BRCA2 mutations are strongly associated with a prostate‐specific antigen response ≥50% during treatment with a platinum agent. However, more work will be required to classify other men who might benefit from platinum agents.See also pages 3532‐9.
The association between germline BRCA2 variants and sensitivity to platinum‐based chemotherapy among men with metastatic prostate cancer
Authors: Pomerantz Mark M. , Spisák Sandor , Jia Li , Cronin Angel M. , Csabai Istvan , Ledet Elisa , Sartor A. Oliver , Rainville Irene , O'Connor Edward P. , Herbert Zachary T. , Szállási Zoltan , Oh William K. , Kantoff Philip W. , Garber Judy E. , Schrag Deborah , Kibel Adam S. , Freedman Matthew L. 
Published: June 2017

BACKGROUNDBreast cancer 2 (BRCA2)‐associated breast and ovarian cancers are sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated prostate cancer responds favorably to such treatment.METHODSA retrospective analysis of a single‐institution cohort of men with castration‐resistant, metastatic prostate cancer was performed to determine the association between carrier status of pathogenic BRCA2 germline variants and prostate‐specific antigen response to carboplatin‐based chemotherapy. From 2001 through 2015, 8081 adult men with prostate cancer who had a consultation and/or underwent treatment at Dana‐Farber Cancer Institute provided blood samples and consented to analyses of biologic material and clinical records. A subgroup of 141 men received at least 2 doses of carboplatin and docetaxel for castration‐resistant disease (94% were also taxane refractory). These patients were categorized according to the absence or presence of pathogenic germline mutations in BRCA2 based on DNA sequencing from whole blood. The primary outcome was the response rate to carboplatin/docetaxel chemotherapy, defined according to a decline in prostate‐specific antigen that exceeded 50% within 12 weeks of initiating this regimen. Associations between BRCA2 mutation status and response to carboplatin‐based chemotherapy were tested using the Fisher exact test, with a 2‐sided P value < .05 as the threshold for significance.RESULTSPathogenic germline BRCA2 variants were observed in 8 of 141 men (5.7%; 95% confidence interval, 2.5%‐10.9%). Six of 8 BRCA2 carriers (75%) experienced prostate‐specific antigen declines >50% within 12 weeks, compared with 23 of 133 noncarriers (17%; absolute difference, 58%; 95% confidence interval, 27%‐88%; P < .001). Prostate cancer cell lines functionally corroborated these clinical findings.CONCLUSIONSBRCA2‐associated, castration‐resistant prostate cancer is associated with a higher likelihood of response to carboplatin‐based chemotherapy than non‐BRCA2–associated prostate cancer. Cancer 2017;123:3532‐9. © 2017 American Cancer Society.
TP53 mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper‐CVAD‐based regimens
Authors: Kanagal‐Shamanna Rashmi , Jain Preetesh , Takahashi Koichi , Short Nicholas J. , Tang Guilin , Issa Ghayas C. , Ravandi Farhad , Garcia‐Manero Guillermo , Yin Cameron C. , Luthra Rajyalakshmi , Patel Keyur P. , Khoury Joseph D. , Montalban‐Bravo Guillermo , Sasaki Koji , Kadia Tapan M. , Borthakur Gautam , Konopleva Marina , Jain Nitin , Garris Rebecca , Pierce Sherry , Wierda William , Estrov Zeev , Cortes Jorge , O'Brien Susan , Kantarjian Hagop M. , Jabbour Elias 
Published: June 2017

BACKGROUNDTumor protein 53 (TP53) mutations are uncommon in adult patients with acute lymphoblastic leukemia (ALL) and predict a poor outcome.METHODSTP53 mutation analysis was performed in 164 newly diagnosed adult patients with ALL using a combination of targeted amplicon‐based next‐generation sequencing and Sanger sequencing.RESULTSTP53 mutations were detected in 25 patients (15%), with a median allelic frequency of 42.2% (range, 5.6%‐93.8%). The majority of mutations were single‐nucleotide variants of missense type and involved the DNA‐binding domain. TP53‐mutated (TP53mut) ALL was found to be significantly associated with older age, lower median white blood cell and platelet counts, lower frequency of Philadelphia chromosome and a higher frequency of low hypodiploid karyotype compared with ALL with wild‐type TP53 (TP53wt). To evaluate the prognostic effect of TP53 mutations, the authors selected 146 patients with B‐cell immunophenotype ALL (24 with TP53mut and 122 with TP53wt) who were uniformly treated with frontline hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper‐CVAD)‐based regimens; >90% of these individuals also received a monoclonal antibody. Over a median follow‐up duration of 15 months, there was no significant difference in the median overall survival, event‐free survival, and duration of complete remission noted between patients with TP53mut ALL and those with TP53wt ALL.CONCLUSIONSHyper‐CVAD‐based regimens appear to negate the poor prognostic impact of TP53 mutations in patients with adult B‐cell immunophenotype ALL. Cancer 2017;123:3717‐24. © 2017 American Cancer Society.