bluuebunny/crossref_metadata_2025_split huggingface dataset:
Di–tert–butyl N,N‐diethylphosphoramidite as an Air Stable Ligand for Suzuki‐Miyaura and Buchwald‐Hartwig Reactions
Authors: Ilie Adriana , Roiban Gheorghe‐Doru , Reetz Manfred T. 
Published: February 2017

AbstractWe describe herein an air stable phosphorus ligand for both Suzuki‐Miyaura and Buchwald‐Hartwig palladium‐catalyzed cross coupling reactions. The versatility of the Pd(dba)2‐di‐tert‐butyl N,N‐diethylphosphoramidite catalytic system is demonstrated for a variety of aryl and heteroaryl halides. This ligand is ‘’bench stable’’ which allows easy catalyst preparation. Moreover, even at low catalyst loadings (0.5 %), excellent yields are usually achieved.
Giving Feedback: Preparing Students for Peer Review and Self‐Evaluation
Authors: Philippakos Zoi A. 
Published: January 2017

AbstractRevision is an important aspect of the writing process but is often challenging for students. Peer review can be helpful, but training is needed for it to work effectively. This article suggests an approach to preparing students for peer review by teaching specific evaluation criteria and leading collaborative practice in reviewing papers written by unknown peers. This practice supports self‐evaluation as well as peer review and increases students’ knowledge of effective writing and the quality of their own writing. Specific examples are presented to demonstrate the effects of this approach.
Does dual tasking ability change with age across childhood and adolescence? A systematic scoping review
Authors: Saxena Shikha , Cinar Eda , Majnemer Annette , Gagnon Isabelle 
Published: February 2017

AbstractThe aim of this literature search was to identify nature and extent of the evidence supporting the development of dual tasking skills in typically developing children. We systematically searched PsycINFO, Ovid and Pubmed for studies evaluating dual task performances of children and adolescents <18 years of age. 31 studies published in English from 1990 to 2016 were included. A descriptive analysis was used for data extraction and charting. Study findings reported that age influenced dual task performances under difficult or complex task conditions but they were found to be inconclusive when the tasks were equated at everyone's difficulty level. Therefore, greater attention should be paid to meet the methodological and interpretive challenges to investigate if task coordination in children is affected by the dual tasking skills or just by development of motor and cognitive systems in isolation.
Patient and caregiver reactions to clinical amyloid imaging
Authors: Grill Joshua D. , Cox Chelsea G. , Kremen Sarah , Mendez Mario F. , Teng Edmond , Shapira Jill , Ringman John M. , Apostolova Liana G. 
Published: February 2017

AbstractIntroductionAmyloid imaging is a tool that has recently become available to dementia specialists evaluating patients with possible Alzheimer's disease. Studies have assessed the impact of amyloid imaging on diagnostic and treatment decisions, but patient and family perspectives have received less attention.MethodsTo examine how amyloid imaging affects the diagnostic experience of patients and families, we interviewed members of 26 patient‐caregiver dyads with whom a neurologist discussed the option of amyloid positron emission tomography.ResultsMost participants who chose to undergo amyloid imaging would choose to do so again. Regardless of the scan outcome, patients and caregivers commonly expressed relief on learning the scan results. Some participants expressed expectations that were beyond scan capabilities.DiscussionAmyloid imaging may provide information that patients and their families find useful. Clinicians must set correct expectations and ensure that families understand the limitations of amyloid imaging.
Psychological and Lifestyle Factors That Influence the Serial Reporting of Postconcussion‐like Symptoms in a Non‐concussed Population
Authors: Balasundaram Arun Prasad , Athens Josie , Schneiders Anthony Gerard , McCrory Paul , Sullivan Stephen John 
Published: February 2017

AbstractBackgroundSymptoms related to concussion are generally nonspecific in nature, as they are also reported by non‐concussed individuals. What is currently not known is whether the symptoms vary over time, and whether they are also influenced by a multitude of factors.ObjectiveThe aim of this study was to investigate the potential influence of psychological, lifestyle, and situational factors on the change in postconcussion‐like symptoms reported over 7 consecutive days in a cohort of normal individuals.DesignThis was a longitudinal observational study.SettingThe setting was a real‐world context.ParticipantsA convenience sample of 180 non‐concussed university students were enrolled. Of these, 110 participants provided data for the entire period of the study.MethodsAn experience‐sampling methodology was used to document the symptoms reported over time. Stepwise multivariate linear mixed‐effects modeling was performed to identify the predictors contributing to the serially reported symptoms.Independent VariablesIndependent variables considered were gender, time of the day, location, primary activity, and type of interactant (person) of the participant, physical activity status, trouble sleeping, alcohol consumption, caffeine consumption, stress, anxiety, depression, mental and physical fatigue, and life stressors.Main Outcome MeasuresThe key outcome measures were the change in total symptom score (TSSchange) and symptom severity score (SSSchange) reported over 7 consecutive days.ResultsThe predictors of location at the time of reporting, physical fatigue (estimate: −0.98, P < .001) and mental fatigue (estimate: −0.53, P < .001) contributed to the TSSchange. Post hoc analysis of the variable of location at the time of reporting revealed that participants reported increased TSSchange when they were at a café/restaurant compared to a flat/college or university.ConclusionsA number of factors within the context of daily life influenced the postconcussion‐like symptoms reported over time. These findings indicate that clinicians need to be cautious when interpreting the serially assessed symptom scores to track the recovery profile of a concussed athlete to make decisions on return‐to‐play. Additional investigation is warranted to examine the change in symptom scores reported over time by concussed individuals, considering that this study was conducted in a nonconcussed cohort.Level of EvidenceNot applicable.
Self‐Reported Driving Difficulty in Veterans With Traumatic Brain Injury: Its Central Role in Psychological Well‐Being
Authors: Winter Laraine , Moriarty Helene J. , Short Thomas H. 
Published: February 2017

BackgroundThe ability to drive is a core function supporting independent living. Traumatic brain injury (TBI) may impair driving capacity in numerous ways. Previous research has documented that individuals with TBI have more driving‐related problems than other people and has identified predictors of driving status or capacity, mostly among civilians; however, no research has examined the implications of driving limitations for the well‐being of individuals with TBI.ObjectiveTo examine the association between self‐reported difficulty in driving with important domains of psychological well‐being in veterans with TBI, with adjustment for posttraumatic stress disorder (PTSD) and years since most recent TBI.DesignCross‐sectional.SettingVeterans' homes.ParticipantsA total of 61 veterans of the Global Wars on Terrorism diagnosed with TBI, all outpatients at a Veterans Affairs medical center rehabilitation service.MethodsHome interviews as a baseline assessment for a larger randomized controlled trial.Main Outcome MeasuresCommunity reintegration (extent of social participation), depressive symptomatology, and role limitations due to physical health problems and those due to emotional problems. Self‐rated competence in driving was the predictor, and sociodemographic characteristics, diagnosis of PTSD, severity of TBI, and time since most recent TBI were covariates.ResultsSelf‐rated driving difficulty was associated with decreased community reintegration (β = .280, P =.028), greater depressive symptomatology (β = −.402, P < .001), and greater role limitations due to physical problems (β = −.312, P =.011) and to emotional problems (β = −.324, P = .006), after we adjusted for PTSD and other variables.DiscussionThe self‐reported ability to drive seems to be central to psychological well‐being in veterans with TBI, showing clear associations with depression, community reintegration, and health‐related role limitations. These associations cannot be attributed to comorbid PTSD.ConclusionRehabilitation specialists should view driving difficulty as a risk factor for poor psychosocial outcomes in veterans with TBI and seek ways to compensate for the veteran's loss of driving if it is no longer advisable.Level of EvidenceII
Convergence and partial regularity for weak solutions of some nonlinear elliptic equation: the supercritical case
Authors: Pacard Frank 
Published: February 2017

In this paper we prove a partial regularity result for stationary weak solutions of

–Δu = u^α

, when

α

is greater than the critical Sobolev exponent.

Résumé

On démontre dans cet article un résultat de régularité partielle pour les solutions faibles stationnaires de

–Δu = u^α

lorsque l’exposant

α

est supérieur à l’exposant critique de Sobolev.
Plenty of elliptic islands for the standard family of area preserving maps
Authors: Duarte Pedro 
Published: February 2017

For the Standard Map, a well-known family of conservative diffeomorphisms on the torus, we construct
large
basic sets which fill in the torus as the parameter runs to

∞

. Then we prove that, for a residual set of large parameters, these basic sets are accumulated by elliptic periodic islands. We also show that there exists a

k_0 > 0

and a dense set of parameters in

[k_0, ∞)

for which the standard map exhibits homoclinic tangencies.

Résumé

Pour l’application Standard, une famille bien connue des difféomorphismes conservatives sur le Tore, on construit des ensembles hyperboliques qui remplissent le tore lorsque le paramètre tend vers l’infini. On démontre alors que pour un ensemble résiduel de grands paramètres ces ensembles hyperboliques sont accumulés par des îles elliptiques périodiques. Nous montrons aussi qu’il existe

k_0 > 0

et un ensemble dense des paramètres dans

[k_0, ∞)

pour lesquels l’application Standard présente des tangences homoclines.
A general approach for multiconfiguration methods in quantum molecular chemistry
Authors: Le Bris Claude 
Published: February 2017

We are concerned with a family of minimization problems arising in Quantum Chemistry for the modelling of the ground state of a molecule. We study the multiconfiguration methods, which are an extension of the well known Hartree–Fock method. We propose a general approach to prove the existence of the ground state in this framework. We apply our approach to two particular cases.

Résumé
Nous nous intéressons à une classe de problèmes de minimisation issus de la chimie quantique. Nous étudions les méthodes multidéterminants (ou multiconfigurations) de modélisation de l’état fondamental d’une molécule. Dans ce cadre, qui est une extension de la théorie de Hartree–Fock, nous proposons une approche générale pour prouver l’existence de l’état fondamental. A titre d’exemple, nous utilisons cette approche pour l’étude de deux cas particuliers.
Prescribing the Jacobian determinant in Sobolev spaces
Authors: Dong Ye 
Published: February 2017

Let

Ω

be a bounded domain in

\mathrm R^n

with regular boundary. In this paper, we study the equations of the type

\det (∇ u (x)) = f

in

Ω

and

u (x) = x

on

∂Ω

where

f

lies in some Sobolev spaces. We establish some existence and non-existence results. A discussion of general cases is also included.

Résumé

Soit

Ω

un domaine borné régulier de

\mathrm R^n

. Dans cet article, nous allons étudier les équations du type

\det (∇ u (x)) = f

dans

Ω

et

u (x) = x

sur

∂Ω

avec

f

appartenant à certains espaces de Sobolev. Nous établissons quelques résultats d′existence et de non-existence. Une discussion pour des cas généraux est aussi incluse.
The initial-boundary value problem for the non-barotropic compressible Euler equations: structural-stability and data dependence
Authors: da Veiga H. Beirão 
Published: February 2017

We study the initial-boundary value problem for general compressible inviscid fluids. Let

\mathrm U_0, \mathrm U'_0 \in \mathrm{H}^{k}

and

U, U' \in C (0, T; \mathrm H^k)

denote initial data and corresponding solutions, respectively. From the point of view of dynamical systems, a very basic problem is to prove that

\mathrm U'

converges to

\mathrm U

in

С (0, Τ; \mathrm H^k)

if

\mathrm{U}_{0}'

converges to

\mathrm U_0

in

\mathrm H^k

; this is proved in Theorem 1.2 below. It must be pointed out that convergence in

C(0, T; \mathrm H^{k − ε})

and in

L^∞(0, T; \mathrm H^k)

weak-

\ast

(easy consequences of the
a priori
estimates used to prove the existence theorem) have minor significance as part of the mathematical theory. We also show (Theorem 1.3) that if

ρ' (p, S)

approaches

ρ (p, S)

in

C^k

then

\mathrm U'

approaches

\mathrm U

in the norm

C (0, T; \mathrm H^k)

. In particular, small perturbations in the law of state generate small perturbations in the trajectory of the solution, with respect to the right metric.

Résumé

Nous étudions le problème mixte pour des fluides non visqueux, dans le cas général. Soient

\mathrm U_0, \mathrm{U}_{0}' \in \mathrm{H}^{k}

et

U, U' \in C (0, T; \mathrm H^k)

respectivement les données initiales et les solutions correspondantes. Du point de vue des systèmes dynamiques, un problème essentiel consiste à démontrer que

\mathrm{U}'

converge vers

\mathrm U

dans

С (0, T; \mathrm H^k)

lorsque

\mathrm{U}_{0}^{′}

converge vers

\mathrm U_0

dans

\mathrm H^k

; on démontre ce résultat dans le Théorème 1.2. En plus, on démontre (Théorème 1.3) que si

ρ′ (p, S)

converge vers

ρ (p, S)

dans

C^k

alors

\mathrm U′

converge vers

\mathrm U

dans

С (0, T; \mathrm H^k)

.
On parabolic initial-boundary value problems with critical growth for the gradient
Authors: Landes Rüdiger , Mustonen Vesa 
Published: February 2017

We prove the existence of weak solutions for the initial-boundary value problem of the quasilinear parabolic equation

\frac{∂u}{∂t} + \mathrm{A}(u) + g(x,\:t,\:u,\:\mathrm{D}u) = f.

Here

\mathrm{A}

is a Leray–Lions type operator from

\mathscr V=\mathrm L^p(o,T,W^{1,p}_0(\Omega))

to its dual space

\mathscr V^*

,

g

is a nonlinear term with critical growth with respect to

\mathrm{D}u

satisfying a sign condition and no growth condition with respect to

u

;

f

is a given element in

\mathscr V^*

.

Résumé
Nous démontrons l’existence des solutions faibles du problème parabolique quasilinéaire

\frac{∂u}{∂t} + \mathrm{A}(u) + g(x,\:t,\:u,\:\mathrm{D}u) = f.

avec conditions aux limites et initiales. Ici

\mathrm{A}

est un opérateur de type Leray–Lions de l’espace

\mathscr V=\mathrm L^p(o,T,W^{1,p}_0(\Omega))

à valeurs dans

\mathscr V^*

,

g

est un terme non linéaire à croissance critique en

\mathrm{D}u

, qui satisfait une condition de signe et dont la croissance en

u

n’est pas limitée;

ƒ

est un élément donné de

\mathscr V^*

.
Mountain pass theorems and global homeomorphism theorems
Authors: Katriel Guy 
Published: February 2017

We show that mountain-pass theorems can be used to derive global homeomorphism theorems. Two new mountain-pass theorems are proved, generalizing the “smooth” mountain-pass theorem, one applying in locally compact topological spaces, using Hofer’s concept of mountain-pass point, and another applying in complete metric spaces, using a generalized notion of critical point similar to the one introduced by Ioffe and Schwartzman. These are used to prove global homeomorphism theorems for certain topological and metric spaces, generalizing known global homeomorphism theorems for mappings between Banach spaces.

Résumé
On montre que des théorèmes du col peuvent être utilisés pour dériver des théorèmes d’homéomorphisme global. On prouve deux nouveaux théorèmes du col qui généralisent le théorème du col « lisse », l’un s’appliquant à des espaces topologiques localement compacts, avec emploi du concept du point de col de Hofer, et l’autre s’appliquant à des espaces métriques complets, en utilisant un concept généralisé de point critique ressemblant à celui introduit par Ioffe et Schwartzman. Ils sont utilisés pour prouver des théorèmes d’homéomorphisme global pour certains espaces topologiques et métriques généralisant des théorèmes d’homéomorphisme global connus concernant des applications entre espaces de Banach.
On the vanishing viscosity approximation to the Cauchy problem for a 2×2 system of conservation laws
Authors: Rubino Bruno 
Published: February 2017

This paper is concerned with a non-strictly hyperbolic system of conservation laws. We study the existence of weak solutions to the associated Cauchy problem, in the framework of

L^∞

, using the methods of compensated compactness. Some previous results for quadratic systems have been generalized.

Résumé

Étant donné un certain système de lois de conservation faiblement hyperbolique, on étudie l’existence d’une solution faible dans

L^∞

du problème de Cauchy associé en utilisant les méthodes de la compacité par compensation. De cette façon, on généralise quelques-uns des résultats connus pour les systèmes quadratiques.
Attention and multisensory modulation argue against total encapsulation
Authors: de Haas Benjamin , Schwarzkopf Dietrich Samuel , Rees Geraint 
Published: January 2017

AbstractFirestone & Scholl (F&S) postulate that vision proceeds without any direct interference from cognition. We argue that this view is extreme and not in line with the available evidence. Specifically, we discuss two well-established counterexamples: Attention directly affects core aspects of visual processing, and multisensory modulations of vision originate on multiple levels, some of which are unlikely to fall “within perception.”
The distinction between perception and judgment, if there is one, is not clear and intuitive
Authors: Keller Andreas 
Published: January 2017

AbstractFirestone & Scholl (F&S) consider the distinction between judgment and perception to be clear and intuitive. Their intuition is based on considerations about visual perception. That such a distinction is clear, or even existent, is less obvious in nonvisual modalities. Failing to distinguish between perception and judgment is therefore not a flaw in investigating top-down effects of cognition on perception, as the authors suggest. Instead, it is the result of considering the variety of human perception.
Feasibility of alternating induction and maintenance chemotherapy in pancreatic cancer
Authors: Hann Alexander , Bohle Wolfram , Egger Jan , Zoller Wolfram 
Published: January 2017

AbstractChemotherapy regimens for pancreatic ductal adenocarcinoma (PDAC) have changed since the introduction of FOLFIRINOX. Due to toxicity, dosage and number of applied cycles are limited. In analogy to chemotherapy strategies in colon cancer we used a scheme of induction, maintenance and re-induction therapy in PDAC to alleviate such toxicities and increase the number of applied cycles. Here we report first experiences with this approach. Data of all patients who received FOLFIRINOX for metastatic or locally advanced PDAC in our center using induction chemotherapy followed by maintenance therapy from 2011 until November 2016 was collected and analyzed retrospectively. Progression free survival was assessed starting induction therapy until progressive disease (PD) during maintenance or treatment pause (PFS1) and until progression during re-induction therapy (PFS2). 13 patients received induction therapy which was followed by maintenance therapy. Re-induction due to PD during therapy was applied in 11 patients. The median PFS1 was 10.6 months (95% CI; 6.7–14.4), PFS2 was 14.1 months (95% CI; 8.2–19.9) and overall survival was 18.3 months (95% CI; 14.8–21.8). The use of FOLFIRINOX as induction, followed by maintenance and re-induction therapy in case of PD is feasible in the treatment of PDAC and might lead to a prolonged PFS with less toxicity.
Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model
Authors: Khan Reas S. , Dine Kimberly , Bauman Bailey , Lorentsen Michael , Lin Lisa , Brown Helayna , Hanson Leah R. , Svitak Aleta L. , Wessel Howard , Brown Larry , Shindler Kenneth S. 
Published: January 2017

AbstractThe ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental autoimmune encephalomyelitis animal model of multiple sclerosis was assessed. Currently, there are no existing optic nerve treatment methods for disease or trauma that result in permanent vision loss. Demyelinating optic nerve inflammation, termed optic neuritis, induces permanent visual dysfunction due to retinal ganglion cell damage in multiple sclerosis and experimental autoimmune encephalomyelitis. ST266, the biological secretome of Amnion-derived Multipotent Progenitor cells, contains multiple anti-inflammatory cytokines and growth factors. Intranasally administered ST266 accumulated in rodent eyes and optic nerves, attenuated visual dysfunction, and prevented retinal ganglion cell loss in experimental optic neuritis, with reduced inflammation and demyelination. Additionally, ST266 reduced retinal ganglion cell deathin vitro. Neuroprotective effects involved oxidative stress reduction, SIRT1-mediated mitochondrial function promotion, and pAKT signaling. Intranasal delivery of neuroprotective ST266 is a potential novel, noninvasive therapeutic modality for the eyes, optic nerves and brain. The unique combination of biologic molecules in ST266 provides an innovative approach with broad implications for suppressing inflammation in autoimmune diseases, and for preventing neuronal damage in acute neuronal injury and chronic neurodegenerative diseases such as multiple sclerosis.
The Effects of Angular Velocity and Training Status on the Dynamic Control Equilibrium
Authors: Alt Tobias , Knicker Axel , Strueder Heiko 
Published: January 2017

AbstractThigh muscle imbalances may impair sports performance and cause injuries. Common diagnostic parameters of knee muscle balance lack practical applicability. This cross-sectional study aimed to evaluate the effects of angular velocity and training status on the dynamic control ratio at the equilibrium point representing the intersection of eccentric knee flexion and concentric knee extension moment-angle curves. 58 trained and 58 untrained male participants (22.1 years, 82.4 kg) performed concentric and eccentric knee flexions (prone position) and extensions (supine position) on an isokinetic dynamometer operating at 30 and 150°/s. Trained participants had significantly higher DCRe moments at all angular velocities compared with their untrained counterparts (trained30,150: 1.86, 1.90 Nm/kg; untrained30,150: 1.56, 1.60 Nm/kg; p<0.001, partial η²=0.345). Dynamic control equilibrium moments rose with increasing velocity (p=0.001, partial η²=0.095), whereas dynamic control equilibrium angles (trained30,150: 28.9, 30.8°; untrained30,150: 26.1, 27.0°) were influenced by training status (p=0.004, partial η²=0.072), but not by angular velocity (p=0.241, partial η²=0.012). Dynamic control equilibrium parameters detect thigh muscle balance and reflect the trained participants’ capacity to resist high eccentric knee flexor moments, especially during fast movements. Direct links to muscular loading during sprinting are conceivable, but warrant further investigation. The assessment of dynamic control equilibrium moments and angles might help physiotherapists and coaches to improve functional muscle screening, injury prevention and purposeful return to sport.