bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a novel prognostic prediction system based on GLIM-defined malnutrition for colorectal cancer patients post-radical surgery
Authors: Yan Xialin , Zhu Junchang , Wang Junqi , Lu Yingjie , Ye Xingzhao , Sun Xiangwei , Jiang Haojie , Li Zongze , He Chenhao , Zhai Wenbo , Dong Qiantong , Chen Weizhe , Yu Zhen , Pan Yifei , Huang Dongdong 
Published: October 2024

BackgroundMalnutrition often occurs in patients with colorectal cancer. This study aims to develop a predictive model based on GLIM criteria for patients with colorectal cancer who underwent radical surgery.MethodsFrom December 2015 to May 2021, patients with colorectal cancer who underwent radical surgery at our center were recruited for this study. We prospectively collected data on GLIM-defined malnutrition and other clinicopathological characteristics. Using Cox regeneration, we developed a novel nomogram for prognostic prediction, which was validated and compared to traditional nutritional factors for predictive accuracy.ResultsAmong the 983 patients enrolled in this study, malnutrition was identified in 233 (23.70%) patients. Multivariate analysis indicated that GLIM-defined malnutrition is the independent risk factor for overall survival (HR = 1.793, 95% CI = 1.390–2.313 for moderate malnutrition and HR = 3.485, 95% CI = 2.087–5.818 for severe malnutrition). The novel nomogram based on the GLIM criteria demonstrated a better performance than existing criteria, with AUC of 0.729, 0.703, and 0.683 for 1-year, 3-year, and 5-year OS, respectively, in the validation cohort. In addition, the risk score determined by this system exhibited significantly poorer short-term and long-term clinical outcomes in high-risk groups in both malnourished and well-nourished patients.ConclusionCombining handgrip strength, serum albumin level, and TNM stage would help improve the predictive effect of GLIM criteria for colorectal cancer patients post-radical surgery and benefit the individual prognostic prediction of colorectal cancer.
Association between tea consumption and stroke in the American adult females: analyses of NHANES 2011–2018 data
Authors: Miao Yongyue , Ma Sijia , Wu Xian 
Published: October 2024

BackgroundEpidemiological surveys show that there is a significant gender difference in the incidence of stroke, with females having a noticeably higher rate than males. Accordingly, it is crucial to seek preventive measures for stroke specifically targeted at females. Although previous studies have shown that tea has been proven to be negatively correlated with stroke, the relationship between tea and stroke in American adult females is still unclear. Therefore, we aimed to investigate the relationship between tea consumption and the occurrence of stroke in American adult females.MethodsThe data analyzed is derived from the NHANES database between 2011 and 2018. The quantity of tea consumed was gathered from a 24-h dietary review. Stroke was identified by using questionnaire. The association between tea consumption and stroke was investigated using a weighted regression model. Then we used interaction testing and subgroup analysis to conduct a thorough analysis. Simultaneously, the association between the sugar content in tea and stroke was examined.ResultsThis study included 5731 adult females aged between 20 and 60 years. Compared to those who did not consume tea, the likelihood of stroke decreased by 9% for each additional 100 g of tea ingested by participants (OR = 0.91, 95%CI: 0.83–1.00). In the unadjusted model, those who drank 307.5–480 g of tea per day had a substantially decreased risk of stroke than those who did not drink tea (OR = 0.23, 95%CI: 0.08–0.64). After adjustment, this relationship also persisted (Model II: OR = 0.23, 95% CI: 0.08–0.64; Model III: OR = 0.23, 95% CI: 0.08–0.66). In both Model II and Model III, there was a statistically significant relationship between consuming 480–744 g of tea per day and the risk of stroke (Model II: OR = 0.39, 95%CI: 0.16–0.94; Model III: OR = 0.42, 95% CI: 0.18–0.98). Subgroup analysis revealed an interaction only with level of education (P = 0.031). Ultimately, we also demonstrated that people who drink sugar free tea have a lower risk of stroke, and even after adjusting for mixed factors.ConclusionThis study suggested that proper tea consumption was associated with a lower risk of stroke in adult females, which recommended drinking sugar free tea.
Effect of nitrogen and phosphorus application on starch characteristics and quality of rice with different nitrogen efficiency
Authors: Yang Guotao , Wang Qin , Zhang Guohao , Jiang Chunyan , Ma Peng , Hu Yungao 
Published: October 2024

IntroductionThe application of nitrogen and phosphorus fertilizers is an important factors affecting the quality of rice, and different nitrogen-efficient rice varieties show significant differences in their response to nitrogen and phosphorus application.MethodsIn this experiment, a low-nitrogen-high efficiency variety (Deyou 4727) and a high-nitrogen-high efficiency variety (Jingyou 781) were selected, and the changes in rice quality and differences in starch structure under nitrogen–phosphorus interaction treatments were determined.ResultsAppearance, flavor, starch content and thermodynamic properties, endosperm cell arrangement, and starch granule morphology and size were significantly influenced by variety, nitrogen-phosphorus interactions, and their interaction effects. The effect of nitrogen fertilizer on quality was greater than that of phosphorus fertilizer. The whiteness and chalkiness rates of Deyou 4727 first decreased and then increased with increasing nitrogen fertilizer application, wheras the appearance quality of Jingyou 781 increased with increasing nitrogen fertilizer application. Starch crystallinity in Deyou 4727 first increased and then decreased with increasing nitrogen fertilizer application, whereas starch crystallinity in Jingyou 781 increased continuously with increasing nitrogen fertilizer application. The application of phosphorus fertilizer led to an increase in starch crystallinity in both nitrogen-efficient rice varieties, consistent with the response of different rice varieties to nitrogen and phosphorus in terms of appearance and chalkiness. With the increasing application of nitrogen and phosphorus fertilizers, the differences in the physicochemical properties and structure of starch became more significant.DiscussionHigh-nitrogen-efficient rice varieties can significantly improve appearance quality under high nitrogen conditions, and the interactions of medium-high nitrogen and low-medium phosphorus can lead to a significant decrease in starch thermal parameters and retention rate, thus improving rice cooking quality. Low-nitrogen-efficient rice varieties can also improve the quality of rice under low-medium-nitrogen conditions with appropriate application of phosphorus fertilizer.
Adverse drug reaction signals mining comparison of amiodarone and dronedarone: a pharmacovigilance study based on FAERS
Authors: Xu Ye , Zhao Bin , He Liqun 
Published: October 2024

BackgroundAmiodarone and dronedarone are both class III antiarrhythmic medications used to treat arrhythmias. The objective of this study was to enhance the current understanding of adverse drug reaction (ADR) associated with amiodarone and dronedarone by employing data mining methods on the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS), and providing a reference for safe and reasonable clinical use.MethodsThe ADR records were selected by searching the FAERS database from 2011 Q3 to 2023 Q3. The disproportionality analysis algorithms, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM), were used to detect signals of amiodarone-related and dronedarone-related ADRs. The ADR profiles of amiodarone and dronedarone categorized by organ toxicity were compared through the Z-test and the Fisher exact test.Results9,295 reports specifically mentioned the use of amiodarone and 2,485 reports mentioned the use of dronedarone among 9,972,109 reports, with the majority of ADRs occurring in males over 60 years old. The United States was responsible for the highest proportion of reported ADRs. Significant system organ classes (SOC) for both included Cardiac disorders, Respiratory, thoracic and mediastinal disorders, and Investigations, etc. At the preferred terms (PTs) level, the more frequent ADR signals for amiodarone were drug interaction (n = 856), hyperthyroidism (n = 758), and dyspnoea (n = 607), while dronedarone were atrial fibrillation (n = 371), dyspnoea (n = 204), and blood creatinine increased (n = 123). Notably, unexpected ADRs, including electrocardiogram T wave alternans (n = 16; EBGM05 = 231.27), accessory cardiac pathway (n = 11; EBGM05 = 140), thyroiditis (n = 178; EBGM05 = 125.91) for amiodarone, and cardiac ablation (n = 11; EBGM05 = 31.86), cardioversion (n = 7; EBGM05 = 22.69), and dysphagia (n = 47; EBGM05 = 3.6) for dronedarone, were uncovered in the instructions. The analysis also revealed significant differences in the ADR profiles of amiodarone and dronedarone, with dronedarone showing higher proportions of cardiac toxicity but lower thyroid toxicity compared to amiodarone.ConclusionThese findings underscore the significance of vigilantly monitoring and comprehending the potential risks linked to the use of amiodarone and dronedarone. New ADRs discovered and clear ADR profiles of amiodarone and dronedarone enhance a thorough understanding of these drugs, which is essential for clinicians to ensure safe use of amiodarone and dronedarone.
Emotion regulation use in daily-life and its association with success of emotion-regulation, self-efficacy, stress, and state rumination
Authors: Int-Veen Isabell , Volz Magdalena , Kroczek Agnes , Fallgatter Andreas J. , Ehlis Ann-Christine , Rubel Julian A. , Rosenbaum David 
Published: October 2024

IntroductionInvestigations on emotion regulation strategies (ERS) primarily focus on the influence of instructed emotion regulation (ER) on outcomes. However, recent work has shown that selection of ERS is dependent on, e.g., situational demands and personal resources.MethodsIn this current investigation, we used an online diary to investigate ERS used by free choice and their association with ER-success, stress and rumination. We identified four factors of ERS: cognitive perspective change, cognitive-behavioral problem-solving, suppression-distraction and body-social ERS. Associations of ERS with stress, state-rumination and ER-success were investigated using multilevel-mixed-models, allowing to separate within- and between-subject effects.ResultsOur results show that, on a within-subject level, all adaptive ERS were positively associated with ER-success, while maladaptive ERS as well as higher stress and state rumination were negatively associated with ER-success. On the other hand, only within-subject cognitive ERS were associated with higher self-efficacy. Maladaptive ERS-use was consequently positively associated with stress and state rumination. Surprisingly, only cognitive perspective change ERS were negatively associated with state rumination. Cognitive-behavioral problem-solving was positively associated with stress and success of emotion regulation.DiscussionWe interpret these results in the light of situational constraints of ERS-use and the importance of the assessment of these in future studies.
Discrimination among American Indian and Alaska Native people: implications for public health communication
Authors: Begay Rene L. , Roland Matthew J. , Blair Irene V. , Brondolo Elizabeth 
Published: October 2024

IntroductionAmerican Indian and Alaska Native People (AI/AN) have experienced discrimination stemming from sustained attempts to erase AI/AN People and their culture or livelihood. Research identifying the types of discrimination experienced by AI/AN People is needed to help individuals recognize discrimination in daily life. We examine experiences of discrimination among an urban AI/AN population using a mixed methods approach.MethodsSelf-identified AI/AN participants (N = 303, n = 294 with complete data; 63% women, mean age = 43 years) were recruited from the Denver-metro area in Colorado. Stress and coping models of discrimination guided our analysis. Exposure to discrimination was quantitatively assessed via the Brief Perceived Ethnic Questionnaire – Community Version (BPEDQ-CV), a self-report measure including four subscales assessing workplace discrimination, social exclusion, physical threat and harassment, and stigmatization. Participants responded to a laboratory recall task in which they described an episode of discrimination and their affective and coping responses. Content analysis was conducted on transcribed responses to illustrate discrimination exposure as reported in the BPEDQ-CV and in prior theoretical work on coping with discrimination.ResultsRepeated measures analyses revealed participants reported experiencing social exclusion more than other forms of discrimination, followed by reports of workplace discrimination, stigmatization, and physical threat. Consistent with these quantitative findings, participants were more likely to recall experiences of social threat (94%), including episodes of workplace discrimination, social exclusion, and stigmatization than physical threat and harassment. Almost half the participants (47%) reported confronting or directly addressing the discrimination, and 38% reported avoiding a direct approach. For 44% of participants, their predominant emotional response included internalizing emotions such as fear/sadness/embarrassment, and another 44% reported experiencing externalizing emotions, including anger.ConclusionOur descriptive findings present the experiences of urban AI/AN People who have experienced many forms of unjust and prejudicial treatment. These data can provide useful information to help the general public and AI/AN individuals more readily recognize and prevent discriminatory behavior, and consequently mitigate deleterious effects of discrimination on health.
Biological effects in normal human fibroblasts following chronic and acute irradiation with both low- and high-LET radiation
Authors: Anello Pasqualino , Esposito Giuseppe 
Published: October 2024

IntroductionRadiobiological studies at low dose rates allow us to improve our knowledge of the mechanisms by which radiation exerts its effects on biological systems following chronic exposures. Moreover, these studies can complement available epidemiological data on the biological effects of low doses and dose rates of ionizing radiation. Very few studies have simultaneously compared the biological effects of low- and high-LET radiations at the same dose rate for chronic irradiation.MethodsWe compared, for the first time in the same experiment, the effects of chronic (dose rates as low as ~18 and 5 mGy/h) and acute irradiations on clonogenicity and micronucleus formation in AG1522 normal human skin fibroblasts in the confluent state exposed to doses of low- and high-LET radiation (gamma rays and alpha particles) to investigate any differences due to the different radiation quality and different dose rate (in the dose range 0.006–0.9 Gy for alpha particles and 0.4–2.3 Gy for gamma rays).ResultsAs expected, alpha particles were more effective than gamma rays at inducing cytogenetic damage and reduced clonogenic cell survival. For gamma rays, the cytogenetic damage and the reduction of clonogenic cell survival were greater when the dose was delivered acutely instead of chronically. Instead, for the alpha particles, at the same dose, we found equal cytogenetic damage and reduction of clonogenic cell survival for both chronic and acute exposure (except for the highest doses of 0.4 and 0.9 Gy, where cytogenetic damage is greater at a low dose rate).ConclusionThe results of this study may have an impact on space and terrestrial radioprotection of humans at low doses and low dose rates, on biodosimetry, and on the use of ionizing radiation in medicine. These results also provide insights into understanding damage induction and cell reaction mechanisms following chronic exposure (at dose rates as low as 18 and 5 mGy/h) to low- and high-LET radiation.
Народная икона: византийское наследие в традиционной культуре (к постановке вопроса)
Authors: Бицадзе Н.В. 
Published: October 2024

Статья посвящена важному и малоизученному феномену русского искусства – народной иконе. Рассмотрены особенности её стилистики и технические характеристики, а также приведены факторы, обосновывающие потребность в народной иконе.
The article is devoted to an important and little-studied phenomenon of Russian art – the folk icon. The features of its style and technical characteristics are considered, and the factors justifying the need for a folk icon are given.
Мемориальное пространство русского зарубежья как феномен отечественной и мировой культуры
Authors: Пархоменко Т.А. 
Published: October 2024

В статье анализируется мемориальное пространство русского зарубежья как часть общего культурного пространства России и русского мира. В центре внимания исследования находится мемориальная культура – культура памяти, которая рассматривается на разнообразном эмпирическом материале существующих в зарубежье русских мемориальных объектов: некрополя, воинских мемориалов, памятников монументального искусства, мемориальных музеев, объектов православной, гражданской, военно-оборонительной архитектуры и др.
The article analyzes the memorial space of the Russian diaspora as a part of the common cultural space of Russia and the Russian world. The focus of the study is memorial culture - the culture of memory, which is considered on a variety of empirical material from Russian memorial sites existing abroad: necropolises, war memorials, monuments of monumental art, memorial museums, objects of Orthodox, civil, military-defensive architecture, etc.
Peranan Filsafat Hukum Dalam Kehidupan Berpancasila
Authors: Budiman Andri 
Published: October 2024

Secara gambaran umum Pancasila dijadikan sebagai falsafah hidup Bangsa, Ideologi Negara, dan Dasar Negara sekaligus dijadikan sebagai sumber dari segala sumber hukum, adalah suatu keharusan untuk dijadikan sebagai pedoman serta wajib dilaksanakan oleh setiap komponen warga negara yang hidup di bingkai Negara Kesatuan Republik Indonesia ini.
Dikatakan sebagai falsafah hidup bangsa karena memang semua point-point penting yang terkandung dalam Pancasila itu merupakan bentuk pengkristalisasian dari seluruh keberagaman budaya, agama, suku, nilai-nilai beradab yang hidup dan berkembang secara turun-temurun dan berabad-abad di masyarakat Indonesia serta segala bentuk perbedaan lainnya mampu diakumulasi dalam satu nilai yang sangat filsofis yakni Pancasila.
Berdasarkan uraian di atas, maka adapun yang menjadi rumusan permasalahnya adalah sebagai berikut : 1. Bagaimana keterkaitan filsafat hukum dengan Pancasila ? 2. Bagaimana penerapan filsafat hukum dan nilai pancasila dalam kehidupan
Keharusan pembuatan hukum berdasar pada Pancasila sebagai ideologi bangsa adalah karena ideologi bangsa merupakan dasar filsafat Negara. Hal ini menunjukkan bahwa sesungguhnya hukum di Indonesia tidak serta merta begitu saja diekspor dari negara satu ke negara yang lainnya, karena setiap hukum yang berlaku pada suatu bangsa adalah cerminan nilai dan moral bangsa yang tersbut. Hukum dapat ditegakkan apabila hukum tersebut sesuai dengan nilai-nilai bangsa itu sendiri. Jadi hukum yang efektif diterapkan adalah hukum yang berdasarkan pada nilai-nilai dari bangsa itu sendiri.
Filsafat hukum memliki keterkaitan dengan pancasila sebagai filosofi pembentukan hukum di Indonesia dan juga sebagai hal pedoman kehidupan untuk berbangsa dan bernegara. Berperan penting dalam meletakan dasar nilai hukum yang filosofis dimana mampu mewujudkan cita cita keadilan, kemanfaatan, dan kepastian di dalam masyarakat.
Methodological Diversity in Health Care master’s Thesis in Finland: A Pilot Study
Authors: Liikanen Eeva , Kilkku Nina , Sinkkonen Merja 
Published: October 2024

Objectives: Master’s level education could strengthen the efforts to sustain and retain professionals in health and social care by providing possibilities of career development. The master’s educations thesis process the students demonstrate their research competence could be one answer to research competence in clinical practice. This research examines what kind of research methods have been used in the master’s level health care education theses in Finland.
Methods: 1056 master’s theses in health care educations in Finland in 2017-2018 were analyzed with the document analysis and categorized as qualitative, quantitative, literature reviews and other methods.
Results: 30% of theses were conducted with qualitative and 12 % with quantitative methods. 6 % were literature reviews while the most were categorized in the other methods (52%).
Conclusions: Results could be partially explained with the context of the study, but at the same time they raise a critical question and need for future research.
A Qualitative Study to Explore Survivors' Experiences in the Implementation of Covid-19 Primary Prevention Efforts in Aceh Province
Authors: Reca Melati Phonna  , Teuku Tahlil  , Dara Febriana  
Published: October 2024

Background: Primary prevention plays an important role in preventing the occurrence of a disease or other health problems including Covid-19. The purpose of this study was to explore the experiences of Covid-19 survivors in implementing primary prevention efforts for Covid-19.
Research Method: This Qualitative study used a phenomenological descriptive design. The Study participants comprised Covid-19 survivors in the capital of Aceh Province, Indonesia. Data were collected using demographic data sheets, Covid-19 primary precaution questionnaires, interview guidelines, field notes, and voice recording devices. Data analysis employed a qualitative data analysis technique.
Results: The study shows two main themes regarding Covid-19 survivors’ experiences in implementing primary prevention efforts for Covid-19: knowledge about primary prevention efforts for Covid-19, and; obstacles in implementing Covid-19 primary prevention (e.g., use of masks, washing hands, physical distancing, etc)
Conclusion: Covid-19 primary prevention implementation can have both positive and negative experiences for survivors (people). Health professionals should consider these in their intervention programs.