bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vivo Validation of PAPSS1 (3′-phosphoadenosine 5′-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target
Authors: Leung Ada W.Y. , Veinotte Chansey J. , Melong Nicole , Oh Min Hee , Chen Kent , Enfield Katey S.S. , Backstrom Ian , Warburton Corinna , Yapp Donald , Berman Jason N. , Bally Marcel B. , Lockwood William W. 
Published: August 2017

Abstract
Purpose: Our previous screening efforts found that inhibition of PAPSS1 increases the potency of DNA-damaging agents in non–small cell lung cancer (NSCLC) cell lines. Here, we explored the clinical relevance of PAPSS1 and further investigated it as a therapeutic target in preclinical model systems.
Experimental Design: PAPSS1 expression and cisplatin IC50 values were assessed in 52 lung adenocarcinoma cell lines. Effects of PAPSS1 inhibition on A549 cisplatin sensitivity under hypoxic and starvation conditions, in 3D spheroids, as well as in zebrafish and mouse xenografts, were evaluated. Finally, the association between PAPSS1 expression levels and survival in patients treated with standard chemotherapy was assessed.
Results: Our results show a positive correlation between low PAPSS1 expression and increased cisplatin sensitivity in lung adenocarcinoma. In vitro, the potentiation effect was greatest when A549 cells were serum-starved under hypoxic conditions. When treated with low-dose cisplatin, PAPSS1-deficient A549 spheroids showed a 58% reduction in size compared with control cells. In vivo, PAPSS1 suppression and low-dose cisplatin treatment inhibited proliferation of lung tumor cells in zebrafish xenografts and significantly delayed development of subcutaneous tumors in mice. Clinical data suggest that NSCLC and ovarian cancer patients with low PAPSS1 expression survive longer following platinum-based chemotherapy.
Conclusions: These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Developing strategies to target PAPSS1 activity in conjunction with platinum-based chemotherapy may offer an approach to improving treatment outcomes. Clin Cancer Res; 23(21); 6555–66. ©2017 AACR.
Neurotensin Receptor 1 Antagonist SR48692 Improves Response to Carboplatin by Enhancing Apoptosis and Inhibiting Drug Efflux in Ovarian Cancer
Authors: Liu Jin , Agopiantz Mikaël , Poupon Joël , Wu Zherui , Just Pierre-Alexandre , Borghese Bruno , Ségal-Bendirdjian Evelyne , Gauchotte Guillaume , Gompel Anne , Forgez Patricia 
Published: August 2017

Abstract
Purpose: The high affinity receptor 1 (NTSR1) and its agonist, neurotensin (NTS), are correlated with tumor cell aggressiveness in most solid tumors. As chemoresistance and tumor aggressiveness are often related, we decided to study the role of the NTSR1 complex within platinum-based chemotherapy responses. In an ovarian model, we studied carboplatin because it is the main standard of care for ovarian cancer.
Experimental Design: Experimental tumors and in vitro studies were performed using SKOV3 and A2780 cells treated with carboplatin, with or without a very specific NTSR1 antagonist, SR48692. We measured the effects of these treatments on cell apoptosis and apoptosis-related proteins, platinum accumulation in the cell and nucleus, and the expression and localization of platinum transporters. NTS and NTSR1 labeling was measured in patients with ovarian cancer.
Results: SR48692 enhanced the response to carboplatin in ovarian cancer cells and experimental tumors. When SR48692 is combined with carboplatin, we noted a major improvement of platinum-induced DNA damage and cell death, as well as a decrease in tumor growth. The relationship of these results to clinical studies was made by the detection of NTS and NTSR1 in 72% and 74% of ovarian cancer, respectively. Furthermore, in a large series of high-grade ovarian cancer, NTSR1 mRNA was shown to correlate with higher stages and platinum resistance.
Conclusions: This study strongly suggests that the addition of NTSR1 inhibitor in combination with platinum salt–based therapy will improve the response to the drug. Clin Cancer Res; 23(21); 6516–28. ©2017 AACR.
Comparing Hospital Staff Nutrition Knowledge, Attitudes, and Practices Before and 1 Year After Improving Nutrition Care: Results From the More‐2‐Eat Implementation Project
Authors: Laur Celia V. , Keller Heather H. , Curtis Lori , Douglas Pauline , Murphy Joseph , Ray Sumantra 
Published: August 2017

AbstractBackground: Staff play key roles in the prevention, detection, and treatment of hospital malnutrition. Understanding staff knowledge, attitudes, and practices (KAP) is important for developing and evaluating change management strategies. Methods: The More‐2‐Eat project improved nutrition care in 5 Canadian hospitals by implementing the Integrated Nutrition Pathway for Acute Care (INPAC). To understand staff views before (T1) and after 1 year of implementation (T2), a reliable KAP questionnaire, based on INPAC, was administered. T2 included questions about involvement in implementation. The mean difference between T2 and T1 responses was calculated, and t tests were used for comparisons. Results: The questionnaire was completed at T1 (n = 189) and T2 (n = 147) (unpaired); 57 staff completed both questionnaires (paired). A significant increase in total score was seen in unpaired results at T2 (from 93.6/128 [range, 51–124] to 99.5/128 [range, 54–119]; t = 5.97, P < .0001), with an increase in knowledge/attitudes (KA) (t = 2.4, P = .016) and practice (t = 3.57, P < .0001) components. There were no statistically significant changes in paired responses. Seventy percent (n = 102/147) noticed positive changes in practices, 12% (n = 18) noticed positive/negative changes, 1% (n = 1) noticed negative change, and 17% (n = 25) noticed no change. Fifty‐nine percent (n = 86) felt involved in the change, and these staff had higher KA and KAP scores than those who did not feel involved. Conclusion: Staff involvement is important in the implementation process for improving nutrition care.
Greenlizardite, (NH4)Na(UO2)2(SO4)2(OH)2·4H2O, a new mineral with phosphuranylite-type uranyl sulfate sheets from Red Canyon, San Juan County, Utah, USA
Authors: Kampf Anthony R. , Plášil Jakub , Nash Barbara P. , Marty Joe 
Published: August 2017

ABSTRACTThe new mineral greenlizardite (IMA2017-001), (NH4)Na(UO2)2(SO4)2(OH)2·4H2O, was found in the Green Lizard mine, Red Canyon, San Juan County, Utah, USA, where it occurs as a secondary alteration phase. It is associated with ammoniozippeite, boussingaultite and dickite. It forms as light green-yellow blades up to ~0.3 mm long. The mineral is vitreous and transparent with a white streak. It fluoresces greenish blue in 405 nm light. Mohs hardness is ~2. Crystals are brittle with irregular fracture and two cleavages: perfect {001} and good {2$\bar 1$0}. Greenlizardite is easily soluble in room-temperature H2O. The calculated density is 3.469 g cm–3. Optically, it is biaxial (+) with α = 1.559(1), β = 1.582(1) and γ = 1.608(1) (measured in white light). The measured 2V is 88(1)°; the calculated 2V is 87.8°. Dispersion is moderate, r < v. Pleochroism is X = very pale yellow green, Y = pale yellow green and Z = light yellow green; X < Y < Z. The optical orientation is X ≈ c, Y ≈ a and Z ≈ b*. The Raman spectrum exhibits bands attributable to both sulfate and uranyl groups. Electron probe microanalyses (with H2O based on the crystal structure) yielded (NH4)0.98Na1.00U1.96S2.04O18.00H10.02. Greenlizardite is triclinic, P$\bar 1$, a = 6.83617(17), b = 9.5127(3), c = 13.8979(10) Å, α = 98.636(7), β = 93.713(7), γ = 110.102(8)°, V = 832.49(8) Å3 and Z = 2. The crystal structure (R1 = 2.39% for 2542 I > 2σI) contains edge-sharing dimers of UO7 pentagonal bipyramids. The dimers link by sharing corners with SO4 groups to form a [(UO2)2(SO4)2(OH)2]2– sheet based on the phosphuranylite anion topology. Zig-zag edge-sharing chains of NaO6 octahedra link adjacent [(UO2)2(SO4)2(OH)2]2– sheets, forming thick slabs. NH4 bonds to O atoms in adjacent slabs linking them together. H2O groups occupy channels in the slabs and space between the slabs.
Adipokines and Their Receptors Are Widely Expressed and Distinctly Regulated by the Metabolic Environment in the Prostate of Male Mice: Direct Role Under Normal and Tumoral Conditions
Authors: Sarmento-Cabral André , L-López Fernando , Luque Raúl M 
Published: August 2017

AbstractAdipose tissue–derived adipokines (i.e., leptin/adiponectin/resistin) play important roles in the regulation of several pathophysiologic processes through the activation of specific receptors. However, although adipokines and their receptors are widely distributed in many tissues and exhibit a clear modulation according to particular metabolic conditions (e.g., obesity and/or fasting), their expression, regulation, and putative action on normal prostate glands (PGs; a hormone-dependent organ tightly regulated by the endocrine-metabolic milieu) are still to be defined. Different in vivo/in vitro models were used to comprehensively characterize the expression pattern and actions of different adipokine systems (i.e., leptin/adiponectin/resistin/receptors) in mouse PGs. Adiponectin, resistin, and adiponectin receptors (1 and 2) and leptin receptor are coexpressed at different levels in PG cells, wherein they are finely regulated under fasting and/or obesity conditions. Furthermore, treatment with different adipokines exerted both homologous and heterologous regulation of specific adipokines/receptor-synthesis and altered the expression of key proliferation and oncogenesis markers (i.e., Ki67/c-Myc/p53) in mouse PG cell cultures, wherein some of these actions might be elicited through extracellular signal–regulated kinase (ERK) activation. Moreover, treatment with leptin, adiponectin, and resistin differentially regulated key functional parameters [i.e., proliferation and migration capacity and/or prostate-specific antigen (PSA) secretion] in human normal and/or tumoral prostate cell lines. Altogether, our data show that various adipokine and receptor systems are differentially expressed in normal PG cells; that their expression is under a complex ligand- and receptor-selective regulation under extreme metabolic conditions; and that they mediate distinctive and common direct actions in normal and tumoral PG cells (i.e., homologous and heterologous regulation of ligand and receptor synthesis, ERK signaling activation, modulation of proliferation markers, proliferation and migration capacity, and PSA secretion), suggesting a relevant role of these systems in the regulation of PG pathophysiology.
A prospective study of the prevalence of periapical pathology in severely worn teeth
Authors: Rees Jeremy S , Thomas M , Naik P 
Published: August 2017

The aim of this article was to carry out a prospective audit on a convenience sample of all new patients referred to the toothwear clinic at Cardiff University Dental Hospital to establish the prevalence of undiagnosed periapical pathology.Clinical Relevance: The low prevalence value for undiagnosed periapical pathology in patients with advanced toothwear suggests that, for many patients, toothwear is a slow process which allows the defence mechanisms of the pulp to counteract the effects of wear. It also questions the necessity of taking routine radiographs of teeth with wear into dentine, in the absence of clinical symptoms. This would reduce the total radiation dose delivered to the patient and preserve valuable healthcare resources.
Periodontal maintenance – overcoming the barriers
Authors: Fardal Øystein 
Published: August 2017

Periodontal maintenance therapy is the most important stage of periodontal treatment, yet compliance is low. Overcoming the barriers associated with the low compliance involves a complex set of problems relating to the patient, the clinician and the interactions between them. It is therefore important to create a periodontal maintenance treatment programme which takes into consideration the needs of each individual patient. In addition, regional variations and differences in practice profiles are also factors to be accommodated in a maintenance programme. Clinical Relevance: Good co-operation between the referring dentist and the specialist is required when recommendations are made to the patient regarding maintenance therapy.
Loss of deciduous teeth – is timing important to the gdp?
Authors: Nunn Rebekka , Murray Alison , Sandler PJ 
Published: August 2017

On a daily basis, GDPs encounter patients with prematurely lost deciduous teeth or, conversely, deciduous teeth retained well past their accepted exfoliaton date. The timing of deciduous tooth loss impacts on many aspects of the developing occlusion. The aim of the article is both to describe this impact and also to set out guidelines which should assist the general dental practitioner in the decision of when to lose deciduous teeth. Clinical Relevance: The timing of deciduous tooth loss is an important concept which, when outside the normal pattern, may have adverse or beneficial side-effects that general dental practitioners should fully understand.
Surgical treatment of femoroacetabular impingement following slipped capital femoral epiphysis
Authors: Oduwole K. O. , de SA D. , Kay J. , Findakli F. , Duong A. , Simunovic N. , Yen Y-M. , Ayeni O. R. 
Published: August 2017

ObjectivesThe purpose of this study was to evaluate the existing literature from 2005 to 2016 reporting on the efficacy of surgical management of patients with femoroacetabular impingement (FAI) secondary to slipped capital femoral epiphysis (SCFE).MethodsThe electronic databases MEDLINE, EMBASE, and PubMed were searched and screened in duplicate. Data such as patient demographics, surgical technique, surgical outcomes and complications were retrieved from eligible studies.ResultsFifteen eligible level IV studies were included in this review comprising 261 patients (266 hips). Treatment groups included arthroscopic osteochondroplasty, surgical hip dislocation, and traditional open osteotomy. The mean alpha angle corrections were 32.14° (standard deviation (sd) 7.02°), 41.45° (sd 10.5°) and 6.0° (sd 5.21°), for arthroscopy, surgical hip dislocation, and open osteotomy groups, respectively (p < 0.05). Each group demonstrated satisfactory clinical outcomes across their respective scoring systems. Major complication rates were 1.6%, 10.7%, and 6.7%, for arthroscopy, surgical dislocation and osteotomy treatments, respectively.ConclusionIn the context of SCFE-related FAI, surgical hip dislocation demonstrated improved correction of the alpha angle, albeit at higher complication and revision rates than both arthroscopic and open osteotomy treatments. Further investigation, including high-quality trials with standardised radiological and clinical outcome measures for young patients, is warranted to clarify treatment approaches and safety. Cite this article: K. O. Oduwole, D. de Sa, J. Kay, F. Findakli, A. Duong, N. Simunovic, Y. Yi-Meng, O. R. Ayeni. Surgical treatment of femoroacetabular impingement following slipped capital femoral epiphysis: A systematic review. Bone Joint Res 2017;6:472–480. DOI: 10.1302/2046-3758.68.BJR-2017-0018.R1.
Historical Cost and Conservatism Are Joint Adaptations That Help Identify Opportunity Cost
Authors: Basu Sudipta , Waymire Gregory B. 
Published: August 2017

Abstract
Braun (The ecological rationality of historical costs and conservatism. Accounting, Economics and Law: A Convivium, this issue) argues that the traditional accounting principles underlying the revenue-expense approach such as Historical Cost and Conservatism are ecologically rational in that they help organizations survive better in uncertain economic environments. More importantly, Braun argues that the revenue-expense approach generates new private information, which informs markets and makes them more effective (Hayek, 1945, The use of knowledge in society. The American Economic Review, 35(4), 519–530), as opposed to merely reflecting back market data under the asset-liability approach (e.g. Sunder, 2011, IFRS monopoly: The Pied Piper of financial reporting. Accounting and Business Research, 41(3), 291–306). We try to explicate the nature of the new private information generated jointly by Historical Cost and Conservatism, and how this information facilitates the survival of individual entrepreneurs and organizations in market competition.
On the General and Measurable Solutions of some Functional Equations
Authors: Nath Prem , Singh Dhiraj Kumar 
Published: August 2017

AbstractThe general solutions of two functional equations, without imposing any regularity condition on any of the functions appearing, have been obtained. From these general solutions, the Lebesgue measurable solutions have been deduced by assuming the function(s) to be measurable in the Lebesgue sense.
CPW-fed Circularly Polarized Slot Antenna with Small Gap and Stick-shaped Shorted Strip for UHF FRID Readers
Authors: Pan Chien-Yuan , Su Chum-Chieh , Yang Wei-Lin 
Published: August 2017

Abstract
A new circularly polarized (CP) slot antenna with a small gap and a stick-shaped shorted strip is presented. The proposed antenna has a sufficient bandwidth for ultrahigh frequency (UHF) radio-frequency identification (RFID) reader applications. The antenna structure consists of a rectangular slot with a small gap, a stick-shaped shorted strip and a 50 Ω coplanar waveguide (CPW) feedline with an asymmetrical ground plane. By using the stick -shaped shorted strip to disturb magnetic current distribution on the slot, the CP radiation can be generated. The measured results demonstrate that the proposed antenna can reach a 10 dB return loss impedance bandwidth of 14.1 % (894–1030 MHz) and a 3 dB axial ratio (AR) bandwidth of 6.4 % (910–970 MHz). The whole antenna size is 80 × 80 × 1.6 mm3.
Special training of inspiratory muscles in fitness activities and exercise capacity in young women
Authors: Mishchenko Viktor , Sawczyn Stanislaw , Cybulska Agnieszka , Pasek Marcin 
Published: August 2017

PurposeThe aim of the study was to determine if an 8-week-long endurance fitness training with elastic belts would increase the strength-endurance of the inspiratory muscles and lung function characteristics, and to assess whether these changes were consistent with an increase in aerobic power and exercise capacity in healthy young women.MethodsTwenty-two females aged 20–25 years were randomly allocated into 2 groups. The experimental group preformed 8-week-long exercises on stationary bikes with an elastic belt on the lower part of the chest. The control group underwent the same workout, without elastic belts. Vital capacity, forced vital capacity, maximal voluntary ventilation, maximal inspiratory and expiratory pressure, sustained maximal inspiratory pressure, physical activity status, and perceived exertion scores were measured. In the incremental exercise test, work capacity and maximal oxygen uptake were assessed. Tidal volume, minute ventilation (VE), oxygen uptake (VO<sub>2</sub>), VE/VO<sub>2</sub>, heart rate (HR), and VO<sub>2</sub>/HR were continuously monitored. The cycle performance at the power of the ventilatory threshold was evaluated on the following day.Results. The fitness training with elastic belts significantly improved the strength and strength-endurance of the inspiratory muscles, the functional cardio-respiratory capabilities, and aerobic work output. In the control group, the studied parameters were not significantly increased.ConclusionsApplying elastic belts to fitness endurance exercises improves the strength and strength-endurance of inspiratory muscles, cardio-respiratory capabilities, and aerobic power, which additionally raises aerobic work output in fitness training of young women.
A New Marker to Determine Prognosis of Acute Pancreatitis: PLR and NLR Combination
Authors: Kaplan Mustafa , Ates Ihsan , Oztas Erkin , Yuksel Mahmut , Akpinar Muhammed Yener , Coskun Orhan , Kayacetin Ertugrul 
Published: August 2017

SummaryBackground: We aimed to investigate the prognostic importance of platelet-lymphocyte ratio (PLR) and neutro - phil-lymphocyte ratio(NLR) combination for patients diagnosed with acute pancreatitis and its relationship with mortality. Methods: This retrospective study was included 142 patients diagnosed with acute pancreatitis. Ranson, Atlanta and BISAP 0h, 24h and 48h scores of the patients were calculated by examining their patient files. The patients were divided into three groups as low-risk, medium-risk and high-risk patients according to their PLR and NLR levels. Results: The number of patients with acute pancreatitis complications such as necrotizing pancreatitis, acute renal failure, sepsis and cholangitis was significantly higher in the high-risk group compared to other groups. Mortality rate was found to be 90% in the high-risk group, 16% in the medium-risk group, and 1.9% in the low-risk group. The number of patients with a Ranson score of 5 and 6, a severe Atlanta score, a BISAP 0h score of 3 and 4, a BISAP 24h and 48h score of 4 and 5 was higher in the high-risk group compared to other groups. PLR-NLR combination, Atlanta and Ranson scores, and C-reactive protein level were determined to be independent risk factors predicting mortality in stepwise regression model. PLR-NLR combination had the highest area under curve value in terms of predicting acute claspancreatitis prognosis and had a similar diagnostic discrimination with other scoring systems. Conclusion: In our study it was found that PLR-NLR combination had a similar prognostic importance with other scoring systems used to determine acute pancreatitis prognosis.
Children’s Horror Fiction: Grzegorz Gortat’s Ewelina and the Black Bird and Don’t Wake Me Up Just Yet
Authors: Slany Katarzyna 
Published: August 2017

Summary
This article attempts to profile the children’s horror story, aka children’s Gothic, by examining two notable examples of this autonomous sub-genre, Grzegorz Gortat’s Ewelina i Czarny Ptak [Ewelina and the Black Bird] and Nie budź mnie jeszcze [Don’t Wake Me Up Just Yet], published in 2013 in the teasingly named series ‘Lepiej w to uwierz!’ [You’d better believe it]. A close reading of both novels shows that their effect depends on the use of a range of motifs and archetypes of fear within a broad, carnivalesque narrative strategy. Another distinctive feature of Gortat’s children’s horror novel is its symbolism. The symbolic meanings are explained and included in the interpretation of each novel. Finally, the article argues that this type of rite-of-passage scary fantasy is both appropriate and stimulating for school-age children.
Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding
Authors: Xi X. J. , Jiang X. B. , Li D. , Guo L. Q. , Zhang J. F. , Wei Z. Z. , Li B. L. 
Published: August 2017

AbstractInduction of 2n pollen is a required technique for cultivating polyploid via sexual polyploidy. Orthogonal design or Taguchi Design was applied to select the best treatment process of 2n pollen induction inPopulus×popularisfrom different levels of the meiosis stage of male flower buds, colchicine concentration, times of injection, and interval between injections. Flow cytometry and chromosome counting were used to identify the triploids from the offspring ofP.×euramericana. (Dode) Guinier pollinated with induced pollen ofP.×popularis. The results showed that high 2n pollen rate can be achieved by selecting the flower buds during diakinesis stage in meiosis, and then injecting 0.6% colchicine 4 times with 2 hours interval. The 2n pollen rate reached 62.10% by this process, and two triploids were obtained, which indicates that it is possible for cultivating triploids via 2n pollen induction by colchicine treatment in poplar. Results and protocol related to 2n pollen induction, polyploid identification and effect of 2n pollen in this study might be applicable in polyploidy breeding in sectionAigeirosandTacamahacaof poplar.