bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Sidoarjo People's Service System (SiPraja)
Authors: Ningtias Mala Nuraif Tri , Mursyidah Lailul 
Published: September 2024

This study explores the implementation of the Sidoarjo People's Service System (SiPraja) in Boro Village, Tanggulangin District, Sidoarjo Regency, focusing on factors influencing its execution. Using purposive sampling, the research identifies communication, resources, disposition, and bureaucratic structure as key factors affecting policy implementation, in line with George Edward III's framework. Findings reveal that SiPraja has been effectively implemented, with bidirectional communication and sufficient human and infrastructural resources. However, challenges persist in the disposition, particularly in adapting to the SiPraja application, and the absence of a standard operating procedure in Boro Village. This study contributes to the understanding of innovative public service systems, emphasizing the need for addressing disposition challenges for enhanced effectiveness.
Highlight :

Effective Bidirectional Communication: SiPraja's success is attributed to robust bidirectional communication, fostering interaction between citizens and government officials.

Resource Sufficiency: Human resources, facilities, and infrastructure are deemed adequate, contributing to the seamless implementation of SiPraja.

Disposition Challenges: Despite overall success, challenges in user disposition towards the SiPraja application highlight the need for targeted interventions and training.

Keywords: SiPraja, Public Service Innovation, Policy Implementation, Bureaucratic Reform, Communication
Юқори тартибли эгри чизиқларни ҳосил бўлишида подерик алмаштиришлар усулининг қўлланиши
Authors: Каримович Муродов Шмидт , Хурсонали уґли Ортиков Азиз 
Published: September 2024

Ушбу мақолада подерик алмаштиришлар усули билан 3 ва 4- тартибли ажойиб эгри чизиқларнинг хосил бўлиши ва ясалиши ҳақида маьлумотлар келтирилади.
Trajectories of Risk in Early Psychosocial Development: Children of Mothers Exposed to Intimate Partner Violence from Refugee and Non-Refugee Backgrounds in a High-Income Country.
Authors: Rees Susan , Fisher Jane , Whitten Tyson , Dean Kimberlie , Green Melissa , Hassoun Fatima , Moussa Batool , Nadar Nawal , Tay Alvin , Mccormack Clare , Steel Zachary , Silove Derrick 
Published: September 2024

Abstract

Early childhood exposure to maternal experiences of intimate partner violence is associated with a range of emotional and behavioural problems. Using five timepoints of annually collected data from the WATCH mental health cohort study of 870 mother-child dyads, half from refugee background, we prospectively examined the impact of maternal perinatal intimate partner violence exposure on children’s risk trajectories of social-emotional development from around two to five years of age. Maternal IPV exposure to physical abuse with or without psychological abuse at baseline was independently associated with 2.45 times greater odds of children following the “intermittent risk” development trajectory, and 4.90 times greater odds of children following the “high increasing risk” trajectory, compared to those in the “none or low risk” group. Children in the “high increasing risk” trajectory were more likely to be male, and mothers were more likely to be born in Australia, have no tertiary education, and experience social difficulties. The study contributes significantly to understanding the deleterious impact of IPV on child development over time, and the risk and protective factors relevant for safeguarding women and ensuring the optimal development of children.
Rotigotine-induced leukoderma; a case report and literature review
Authors: Bondariyan Niloofar , Golsorkhi Mohadese , Dashtipour Khashayar 
Published: September 2024

Abstract

Introduction:
Rotigotine is a dopamine receptor agonist commonly prescribed for Parkinson’s disease (PD) and restless leg syndrome. Although some common side effects have been previously reported, the rotigotine induced leukoderma is a very rare presentation.
Case Presentation:
Herein, we report a 37-year-old female with PD who developed depigmentation patches after one year of rotigotine application. Dermatology consultation reported drug-induced leukoderma, and topical steroid, narrow-band ultraviolet B, and ruxolitinib were administered. Her depigmentation spots started to improve while rotigotine was continued.
Conclusions
This case highlights the potential for ritogotine to induce skin depigmentation and emphasizes the need for continued observation and reporting of such adverse effects.
Novel Stent Graft Design to Reduce Access Site Puncture Diameter for Endovascular Repair of Infra-Renal Abdominal Aortic Aneurysms: First Two Cases
Authors: Adiarto Suko , Kang Sung Gwon , Taofan Taofan , Indriani Suci , Setiawan Moira , Kurnianingsih Novi , Dakota Iwan , Uberoi Raman 
Published: September 2024

Abstract

We report on an innovative approach in two patients to reduce the access size in the contralateral access which has the potential to reduce access site complications, particularly in patients with smaller femoral arteries. The device is developed by using a standard EVAR device with customized modification of its structure according to the patient’s anatomy. It comprises of a bifurcated stent graft. a proximal extension graft and a contra-lateral limb extension. In our first two cases, we demonstrated that our design, which include direct flow from the abdominal aorta to the ipsilateral limb and retrograde flow to contra-lateral limb worked very well in terms of sealing, with no endoleaks observed, as well as inflow in the stent graft. While long-term results and further refinement are awaited, this approach holds potential in reducing access-related complications and expanding the options for EVAR in patients with small femoral arteries.
Government Subsidies, Executive Incentives, and Firm Performance: A Tripartite Evolutionary Game Analysis
Authors: Jiang Chenxi , Luo Yiheng 
Published: September 2024

Abstract

This study delves into the mechanisms of effective collaboration among governments, enterprises, and executives to achieve the dual goals of environmental conservation and economic growth within the framework of oversight on environmental, social, and governance (ESG) performance. A tripartite game-theoretic model is developed, and a numerical simulation is carried out using MATLAB 2016a. The findings reveal that enterprises and executives may choose passive participation in environmental protection strategies or engaging in free-riding behaviors because of weak government supervision when the government’s regulatory benefits is less than the subsidy costs, primarily due to insufficient government punishment. Conversely, the positive participation is chosen when the incentives surpass the costs of active engagement among the trad. This suggests enhancement of government monitor and evaluation mechanisms to guarantee the effective allocation of subsidies, coupled with substantive environment actions by enterprises and executives. Forster a strategic shift towards sustainable development, thereby improving the company’s ESG performance.
Prevalence, rate, and predictors of virologic failure among adult HIV-Infected clients on second-line antiretroviral therapy (ART) in Tanzania (2018-2020): A retrospective cohort study
Authors: MWAVIKA ESTER TIMOTHY , Kunambi Peter Ponsian , Masasi Samuel Joseph , Lema Nsiande , Kamori Doreen , Matee Mecky 
Published: September 2024

Abstract

Background
Antiretroviral Therapy (ART) has been proven to be highly effective in reducing the impact of Human Immunodeficiency Virus (HIV) infection. However, as more people receive initial ART treatment, the risk of developing resistance and eventual treatment failure increases, leading to the need for second-line treatment regimens. Understanding the factors that contribute to virologic failure to second-line ART is crucial in preventing switching to the more expensive and toxic third-line regimens. This study provides information on the prevalence, rate, and predictors of virologic failure (VF) among clients on second-line ART in Tanzania.
Results
We followed 4,718 clients for 15,100 person-years (PY) of observations. Of them, 1,402 experienced virologic failure, equivalent to 29.72% at a rate of 92.85 per 1000 PY of observations (95% CI 88.11, 97.84). Factors that were associated with VF included: having a viral load count of ≥ 1000 copies/mL during first-line ART, with a hazard ratio (HR) (4.65 (95% CI 3.57, 6.07), using lopinavir (LPV/r) as a protease inhibitor during second-line ART (HR 4.20 (95% CI 3.12, 7.10), having a CD4 count < 200 cells/mm3 during second-line ART (HR 1.89 (95% CI 1.46, 2.44), and being on ART for 13–35 months (HR 8.22 (95% CI 2.21, 30.61). Paradoxically, having a CD4 count < 200 cells/mm3 during first-line ART treatment was associated with a reduced risk of virologic failure (HR 0.77 95% CI 0.60, 0.99).
Conclusions
In Tanzania, approximately 30% of the adult clients on second-line ART experience VF at a rate of 92.71 per 1000 person-years. This high virologic failure rate highlights the need for targeted interventions for HIV-infected clients on second-line ART to reduce the need for switching to the more costly and relatively more toxic third-line ART therapy and help to achieve the third UNAIDS goal of achieving viral suppression for 95% of those treated by 2030.
Opportunities to Advance Equity Through Implementation Strategy Design
Authors: HOSKINS KATELIN , Maye Melissa , Wright Leslie , Jager-Hyman Shari , Wolk Courtney Benjamin , Ahmedani Brian , Boggs Jennifer M , Johnson Christina , Linn Kristin , Quintana LeeAnn , Pappas Celeste , Beidas Rinad S 
Published: September 2024

Abstract

Background: Implementation strategies are potential tools for advancing equity goals in healthcare. Implementation scientists have increased attention to the integration of equity considerations into implementation research, but limited concrete guidance is available for developing implementation strategies to improve equity.
Main: In parallel to an active hybrid effectiveness-implementation trial in two large health systems, our research team explored potential inequities in implementation across four non-study clinics, developed equity focused audit and feedback procedures, examined the feasibility of our approach, and identified design insights that could be tested in future work to inform equitable program scale-up. Based on our experiences deploying these strategies in pilot format, our research team identified key complexities meriting further examination in future work. These considerations are vital given the dearth of guidance on delivering feedback to clinicians in efforts to improve equity. Key takeaways include the importance of understanding local data culture, engaging constituents in co-design for the full feedback cycle, leveraging feedback for shared discourse, and centering multi-level strategies as part of robust implementation approaches.
Conclusion: Prioritizing health equity in implementation science requires that research teams probe, interrogate, and innovate – and in doing so, grapple with central conceptual and pragmatic considerations that arise in the design of implementation strategies. Our work emphasizes the value of bidirectional and continuous learning.
Application of Buckling restrained braces as lateral strengthening method for on-slopping ground reinforced concrete frame structures under severe earthquake loads
Authors: Niyonyungu Ferdinand 
Published: September 2024

Abstract

Buckling restrained braces (BRB) have been proven to be one of the critical horizontal loads resisting structural elements due to their energy dissipation characteristics. Through numerical computational methods using finite element software ETABS, seismic characteristics of- slopping round reinforced concrete frames with different slopes were studied and buckling restrained braces ‘strengthening schemes against their irregularity were proposed. Response spectrum analysis has been used to study the characteristics of typical on-sloping ground frame structures located in regions with seismic intensity eight by using Chinese code for seismic design of building structures GB 2011-2010. It has been found that as the slope increases, the deflection increases, and the period of vibration decreases. It has also been determined that when the slope is only in one direction, the discrepancy between X and Y direction responses will increase as the angle of inclination increases; lastly, it has been found that this type of frame structure will suffer from stiffness irregularity with the severity that increases as the angle of inclination increases. Recent literature has also determined and confirmed that structures on the sloping ground will suffer uneven distribution of internal forces due to the constraints of the columns on the upper side of the slope. To correct all these characteristics, buckling restrained braces were proposed and compared with ordinary steel braces using nonlinear time history analysis. Our results demonstrate that BRB can handle safety issues associated with slopping ground-reinforced concrete frame structures.
Construction and validation of a predictive model for malignant tumors in patients with membranous nephropathy
Authors: Zhai Yaling , Sun Shuaigang , Zhang Wenhui , Tian Huijuan , Zhao Zhanzheng 
Published: September 2024

Abstract

Background
The association between membranous nephropathy (MN) and malignant tumor has long been focused. However, existing studies mostly focused on patients diagnosed of malignant tumors within a limited timeframe (typically defined as 1 year) before or after the diagnosis of MN. Actually, this represents only a subgroup of MN patients complicated with malignant tumors, and those complicated with malignant tumors without a limited period of time haven’t received attention and research. In this study, we aimed to explore the clinicopathologic characteristics of MN patients complicated with malignant tumors, and establish an effective predictive model for identifying the risk of malignant tumors in patients with MN.
Methods
A total of 194 MN patients with malignant tumors and 604 idiopathic MN patients without malignant tumors were retrospectively recruited in this study. All of the patients were then randomly separated (3:1) into the training cohort (n = 599) and the validation cohort (n = 199). A predictive model was constructed based on regression analysis and the model performance, calibration ability and clinical utility were subsequently assessed via the area under the ROC curve (AUC), calibration curve and decision curve analysis (DCA).
Results
A predictive model basedd on age, hemoglobin, degree of arteriole injury, glomerular IgG1, IgG2, IgG3, IgG4, and PLA2R deposition were constructed. The predictive model exhibited a diagnostic power of 0.890 and 0.960 in the training and validation cohorts, respectively, and was validated to demonstrate strong calibration capability and clinical utility.
Conclusion
In this largest cohort with MN and malignant tumors up to date, we constructed a model based on clinical and pathological parameters, to effectively estimate the risk of malignant tumors in patients with MN. This tool aims to assist clinicians in their decision-making process and improve the prognosis for high-risk MN patients by facilitating tumors screening at the time of initial diagnosis.
Title: Investigating Spontaneous Regression in Large Congenital Melanocytic Nevus: A Single-Cell Transcriptomic Study
Authors: Jin Jiamin , Lai Bohan , Gu Jieyu , Yang Ran , Wei Boxuan , Xie Feng 
Published: September 2024

Abstract

Background
Large congenital melanocytic nevus (LCMN) is a lifelong and potentially malignant skin melanocytic tumor. Case reports have documented spontaneous hypopigmentation of congenital melanocytic nevi, with histological evidence of immune cell infiltration in the lesions.
Objective
To explore the mechanism behind the spontaneous regression of LCMN.
Methods
Using Sanger sequencing and 10x Genomics single-cell RNA sequencing technology, we analyzed the genotype and cell population transformations during the spontaneous regression of LCMN.
Results
Our findings highlight the pivotal role of IFN-II in regressing LCMN by reversing immune evasion. IFN-II stimulates melanocytes, enhancing their antigen presentation function to recruit cytotoxic immune cells. Endothelial cells and fibroblasts further amplify the inflammatory response and help reconstruct the tumor microenvironment. The regressed LCMN displayed a marked reduction in melanocytes, increased immune cell infiltration, and remodeling of the tumor microenvironment, characterized by angiogenesis and fibroblast activity.
Conclusion
This study is the first to apply single-cell RNA sequencing technology to LCMN. Our unique sample provides novel insights into the tumor microenvironment of LCMN and its immune mechanisms, offering potential avenues for immunotherapy. Our findings suggest that IFN-II therapy, TIL therapy, and DC immunotherapy could be promising treatment options for LCMN, pending further validation in larger patient cohorts and transgenic animal models.
Investigating the Impact of Rotational Training Structures on Ownership in Public Health: A Qualitative Study
Authors: Taks N.J.L.M. , Rossum T.R. van , Warris L.T. , Reurslag E. , Sadrzadeh S. 
Published: September 2024

Abstract

Introduction: Postgraduate medical education (PGME) relies on structured training rotations and workplace-based learning (WBL) to provide comprehensive clinical training and professional development. Emphasizing WBL, PGME integrates theoretical knowledge with practical skills through direct patient care involvement, underscoring the pivotal role of training institutes in supporting these initiatives. While curricular changes in PGME have been extensively studied in clinical teaching hospitals, PGME programs in Public Health (PGME-PH) remain underexplored, yet their multidisciplinary nature post-COVID-19 underscores the urgency for effective curricular reforms. This study explores how training institutions offering PGME-PH navigate the adoption of structured training rotations by examining organizational perspectives to enhance sustainability and integration of educational innovations in this unique context.
Methods: Semistructured interviews were conducted with 14 participants from training institutions offing PGME-PH in the Netherlands between October and November 2022 to explore their experiences with the implementation of a rotational training structure. The interviews were guided by the Consolidated Framework for Implementation Research (CFIR).
Results: The analysis identified three pivotal themes influencing sustainable implementation and ownership: influence, communication, and motivation. Participants expressed concerns about reduced influence in organizing PGME-PH and noted significant communication challenges, such as ambiguity in roles, program frameworks, and financial aspects. Despite these obstacles, participants showed strong motivation for education and underscored the importance of collaboration and shared responsibility.
Conclusion: The successful implementation of structured training rotations was negatively impacted by training institutions’ experience of limited influence and communication challenges. This led to diminished ownership of the new PGME-PH curriculum, potentially affecting its long-term sustainability. Despite these challenges, participants maintain high motivation for educational delivery. Enhancing sustainable implementation requires fostering ownership, promoting collective responsibility, establishing clear communication channels, and nurturing motivation. These factors are crucial for ensuring the success and longevity of educational programs such as PGME-PH.
Investigating the gut microbiome in Schizophrenia cases versus controls: South Africa’s version
Authors: Rust Carlien , Asmal Laila , O'Hare Michaela , Pretorius Etheresia , Emsley Robin , Seedat Soraya , Hemmings Sian 
Published: September 2024

Abstract

Background
Schizophrenia (SCZ) is a chronic and severe mental disorder with a complex molecular aetiology. Emerging evidence indicates a potential association between the gut microbiome and the development of SCZ. Considering the under-representation of African populations in SCZ research, this study aimed to explore the association between the gut microbiome and SCZ within a South African cohort.
Methods
Gut microbial DNA was obtained from 89 participants (n = 41 SCZ cases; n = 48 controls) and underwent 16S rRNA (V4) sequencing. Data preparation and taxa classification were performed with the DADA2 pipeline in R studio followed by diversity analysis using QIIME2. Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC) was utilised to identify differentially abundant taxa.
Results
No statistically significant differences were observed between SCZ patients and controls in terms of alpha-diversity (Shannon q = 0.09; Simpson q = 0.174) or beta-diversity (p = 0.547). Five taxa, namely Prevotella (p = 0.037), Faecalibacterium (p = 0.032), Phascolarctobacterium (p = 0.002), Dialister (p = 0.043), and SMB53 (p = 0.012), were differentially abundant in cases compared to controls, but this observation did not survive correction for multiple testing.
Conclusion
This exploratory study suggests a potential association between the relative abundance of Prevotella, Faecalibacterium, Phascolarctobacterium, Dialister, and SMB53 with SCZ case-control status. Given the lack of significance after correcting for multiple testing, these results should be interpreted with caution. Larger studies are warranted to confirm these findings and to better comprehend the associations between the gut microbiome and SCZ.
Mechanical ventilation and length of stay prediction using heart rate variability at ICU admission in Covid-19 patients in sitting position: a prospective study
Authors: FARIÑA-GONZÁLEZ Tomás Francisco , MARTINEZ-SAGASTI Fernando , HERNANDO María Elena , OROPESA Ignacio , NUÑEZ-REIZ Antonio , GONZÁLEZ-GALLEGO Miguel Ángel , LATORRE Julieta , QUINTANA-DIAZ Manuel 
Published: September 2024

Abstract

Background
heart rate variability (HRV) is an important part of cardiovascular response to stress. Literature about the utility of HRV to predict intubation and invasive mechanical ventilation (IMV) need in Covid-19 patients is scarce. We analysed if HRV metrics could be used to identify, in the first 24 hours from admission in the intensive care unit (ICU), those patients who were going to need IMV during their stay.
Methods
we conducted a prospective single-centre observational study. Adult patients admitted in the ICU with respiratory failure due to RT-PCR-confirmed SARS-CoV-2 but not under IMV were included. Electrocardiogram (EKG) was recorded at least for 15 minutes at 500 Hz during a stable sitting condition, in the morning time. Power spectrum was obtained using wavelets. We also analysed non-linear HRV dynamics.
Results
27 patients were included. We found no differences in HRV metrics between groups. However, in the linear regression model for ICU length-of-stay (ICU LOS), we found that DFA⍺2 (OR -64.16; 95% CI: -3.497–0.832, P = 0.013), Fi02 (OR 0.37; 95% CI: 0.032–0.71, P = 0.033) and temperature (OR 16.02; 95% CI: 3.537–28.5, P = 0.014) were associated with longer ICU LOS. When performing bivariate correlation in patients lately intubated (Spearman`s test, n = 15), only DFA⍺2 was correlated (r -5.11, p = 0.05) with ICU LOS.
Conclusion
We found that HRV on ICU admission did not discriminate patients that might require IMV. DFA⍺2 was the HRV variable with the strongest association with ICU LOS along with other easy-to-collect clinical variables. These results could be helpful for newer prognostication tools.