bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of person-centred integrated chronic heart failure and palliative home care on pharmacological heart failure treatment: a substudy of a randomised trial
Authors: Markgren Rickard , Brännström Margareta , Lundgren Claes , Boman Kurt 
Published: January 2016

ObjectivePatients with chronic heart failure (CHF) may be insufficiently treated pharmacologically. Recently, we presented a person-centred integrated Palliative advanced homecaRE and heart FailurE caRe (PREFER) strategy and compared it with usual care (control). Patients managed according to PREFER had improved health-related quality of life and markedly reduced hospitalisations compared with the control group. We hypothesised that these improvements may have been partly due to better drug treatments within the PREFER strategy. Thus, our aim in this study was to explore the management of drug treatments in the PREFER group compared with the control group.MethodsDoses and numbers of drugs and the number of patients receiving the target doses based on current guidelines were measured and compared between the groups at the start and finish of the study.ResultsThe percentages of ACE inhibitors (ACEIs) or mineralocorticoid receptor antagonists (MRAs) increased, while loop diuretics decreased in the PREFER arm during the study, although the differences were not significant. Beta-receptor blockers (BBs) decreased somewhat in both groups. The number of patients treated with MRAs differed the most between groups, and increased from 10 (28%) to 15 (48%) in the PREFER arm compared with 13 (35%) vs 13 (39%) in the control group. The change in patients receiving full target doses (+8 vs. +1) of the ACEIs/angiotensin receptor blockers, BBs and MRAs were significantly higher (p=0009) in the PREFER arm than in the control arm.ConclusionsPerson-centred integrated care of patients with severe CHF was associated with increased evidence-based drug treatments, especially MRAs.Clinical trial numberNCT01304381.
Colorings, determinants and Alexander polynomials for spatial graphs
Authors: Mellor Blake , Kong Terry , Lewald Alec , Pigrish Vadim 
Published: January 2016

A balanced spatial graph has an integer weight on each edge, so that the directed sum of the weights at each vertex is zero. We describe the Alexander module and polynomial for balanced spatial graphs (originally due to S. Kinoshita, Alexander polynomials as isotopy invariants I, Osaka Math. J. 10 (1958) 263–271.), and examine their behavior under some common operations on the graph. We use the Alexander module to define the determinant and [Formula: see text]-colorings of a balanced spatial graph, and provide examples. We show that the determinant of a spatial graph determines for which [Formula: see text] the graph is [Formula: see text]-colorable, and that a [Formula: see text]-coloring of a graph corresponds to a representation of the fundamental group of its complement into a metacyclic group [Formula: see text]. We finish by proving some properties of the Alexander polynomial.
Near-real-time service provision during effusive crises at Etna and Stromboli: basis and implementation of satellite-based IR operations
Authors: Miller Peter I. , Harris Andrew J. L. 
Published: January 2016

Abstract
Using the NEODAAS-Dundee AVHRR receiving station (Scotland), NEODAAS-Plymouth can provide calibrated brightness temperature data to end users or interim users in near-real time. Between 2000 and 2009 these data were used to undertake volcano hot spot detection, reporting and time-average discharge rate dissemination during effusive crises at Mount Etna and Stromboli (Italy). Data were passed via FTP, within an hour of image generation, to the hot spot detection system maintained at Hawaii Institute of Geophysics and Planetology (HIGP, University of Hawaii at Manoa, Honolulu, USA). Final product generation and quality control were completed manually at HIGP once a day, so as to provide information to onsite monitoring agencies for their incorporation into daily reporting duties to Italian Civil Protection. We here describe the processing and dissemination chain, which was designed so as to provide timely, useable, quality-controlled and relevant information for ‘one voice’ reporting by the responsible monitoring agencies.
BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer
Authors: Asangani Irfan A. , Wilder-Romans Kari , Dommeti Vijaya L. , Krishnamurthy Pranathi M. , Apel Ingrid J. , Escara-Wilke June , Plymate Stephen R. , Navone Nora M. , Wang Shaomeng , Feng Felix Y. , Chinnaiyan Arul M. 
Published: January 2016

Abstract
Next-generation antiandrogen therapies, such as enzalutamide and abiraterone, have had a profound impact on the management of metastatic castration-resistant prostate cancer (mCRPC). However, mCRPC patients invariably develop resistance to these agents. Here, a series of clonal cell lines were developed from enzalutamide-resistant prostate tumor xenografts to study the molecular mechanism of resistance and test their oncogenic potential under various treatment conditions. Androgen receptor (AR) signaling was maintained in these cell lines, which acquired potential resistance mechanisms, including expression of AR-variant 7 (AR-v7) and glucocorticoid receptor. BET bromodomain inhibitors were shown previously to attenuate AR signaling in mCRPC; here, we demonstrate the efficacy of bromodomain and extraterminal (BET) inhibitors in enzalutamide-resistant prostate cancer models. AR antagonists, enzalutamide, and ARN509 exhibit enhanced prostate tumor growth inhibition when combined with BET inhibitors, JQ1 and OTX015, respectively. Taken together, these data provide a compelling preclinical rationale to combine BET inhibitors with AR antagonists to subvert resistance mechanisms.
Implications: Therapeutic combinations of BET inhibitors and AR antagonists may enhance the clinical efficacy in the treatment of mCRPC.
Visual Overview: http://mcr.aacrjournals.org/content/14/4/324/F1.large.jpg. Mol Cancer Res; 14(4); 324–31. ©2016 AACR.
Effect of oral factor Xa inhibitor and low-molecular-weight heparin on surgical complications following total hip arthroplasty
Authors: Kim Sang-Min , Moon Young-Wan , Lim Seung-Jae , Kim Dong-Wook , Park Youn-Soo 
Published: January 2016

SummaryThis prospective study was conducted to report the effect of oral factor Xa inhibitor and low-molecular-weight heparin (LMWH) on surgical complications following total hip arthroplasty (THA). The patients with an age < 60 years were randomly assigned to three groups (rivaroxaban, enoxaparin, and placebo) and the patients with an age ≥ 60 years were assigned to two groups (rivaroxaban and enoxaparin). All drug regimens started at 12 hours postoperatively and continued for two weeks after surgery. Primary measure outcome was major surgical wound complications defined as haematoma requiring any intervention, superficial wound infection, deep periprosthetic infection, and increased wound bleeding. Secondary measured outcome included minor surgical complications (swelling, drainage, erythema, and oozing), organ bleeding, and venous thromboembolic (VTE) events. A total of 184 patients aged < 60 years and 167 patients aged ≥ 60 years were included as the analysis population per group. Up to 14 days after surgery, the overall incidence of major surgical complications associated with thromboprophylaxis was 6.5 % (58/886). There were no significant differences in the rate of major surgical complications among all the three groups of the patients aged < 60 years and between two groups of the patients aged ≥ 60 years. For the patients aged < 60 years, wound oozing continued significantly longer in the pharmacological group than in the placebo group, but wound infection did not occur in any case. The VTE events were similar in all the groups.
Stem cell mobilisation by granulocyte-colony stimulating factor in patients with acute myocardial infarction
Authors: Hadamitzky Martin , Ibrahim Tareq , Groha Philip , Schunkert Heribert , Laugwitz Karl-Ludwig , Kastrati Adnan , Ott Ilka , Steppich Birgit ,   for the Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL-2) Study Investigators
Published: January 2016

SummaryTreatment with granulocyte-colony stimulating factor (G-CSF) mobilises cells from the bone marrow to the peripheral blood. Previous preclinical and early clinical trials may suggest that treatment with G-CSF leads to improved myocardial perfusion and function in acute or chronic ischaemic heart disease. In the REVIVAL-2 study we found that stem cell mobilisation by G-CSF does not influence infarct size, left ventricular function and coronary restenosis in patients with acute myocardial infarction (MI) that underwent successful percutaneous coronary intervention. The objective of the present analysis was to assess the impact of G-CSF treatment on seven-year clinical outcomes from the REVIVAL-2 trial. In the randomized, double-blind, placebo-controlled REVIVAL-2 study, 114 patients with the diagnosis of acute myocardial infarction were enrolled five days after successful reperfusion by percutaneous coronary intervention. Patients were assigned to receive 10 μg/kg G-CSF (n=56) or placebo (n=58) for five days. The primary endpoint for this long-term outcome analysis was the composite of death, myocardial infarction or stroke seven years after randomisation. The endpoint occurred in 14.3% of patients in the G-CSF group versus 17.2%> assigned to placebo (p=0.67). The combined incidence of death or myocardial infarction occurred in 14.3%> of the patients assigned to G-CSF and 15.5%> of the patients assigned to placebo (p=0.85). In conclusion, these long-term follow-up data show that G-CSF does not improve clinical outcomes of patients with acute myocardial infarction.
Argatroban pharmacokinetics and pharmacodynamics in critically ill cardiac surgical patients with suspected heparin-induced thrombocytopenia
Authors: Zimmer Emanuel , Bek Martin , Wiessner Michael , Keyl Cornelius , Trenk Dietmar 
Published: January 2016

SummaryOnly limited data are available on the pharmacokinetic and pharmacodynamic properties of argatroban in critically ill patients under clinical conditions. We determined plasma concentrations of argatroban, and its main metabolite M1, within a time period of 48 hours in 25 critically ill cardiac surgical patients, who were suspected of heparininduced thrombocytopenia and had the clinical need for anticoagulation. Argatroban infusion was started at 0.5 µg/kg/minute, and adjusted in 0.1–0.25 µg/kg/minute increments when the activated partial thromboplastin time (aPTT) was not within the target range. Median argatroban plasma half-life was 2.7 hours (interquartile range 1.8 to 7.3). Linear regression analysis revealed that argatroban half-life was significantly related to the total bilirubin concentration (R2 = 0.66, p< 0.001), as well as to the metabolism of argatroban, which was assessed by the ratio of the areas under the concentration time curves (AUC) of argatroban and M1 (R2 = 0.60, p< 0.001). Continuous veno-venous haemodialysis did not significantly affect argatroban plasma half-life. The predictive property of argatroban plasma levels for aPTT was low (R2 = 0.28, p< 0.001). Multiple linear regression analysis revealed significant contributions of age and serum albumin levels to the effect of argatroban on aPTT, expressed as the AUC ratio argatroban/aPTT (R2 = 0.67, adjusted R2 = 0.65, p< 0.001). In conclusion, argatroban plasma half-life is markedly increased in critically ill cardiac surgical patients, and further prolonged by hepatic dysfunction due to impaired metabolism. Patient age and serum albumin concentration significantly contribute to the variability in the anticoagulant activity of argatroban.
The Extra-Area Effect of Orographic Cloud Seeding: Observational Evidence of Precipitation Enhancement Downwind of the Target Mountain
Authors: Jing Xiaoqin , Geerts Bart , Boe Bruce 
Published: January 2016

AbstractThis study uses scanning X-band Doppler on Wheels (DOW) radar data to examine whether ground-based glaciogenic seeding influences orographic precipitation, inadvertently, over the foothills of a mountain ~50 km downwind of the target mountain. The data were collected during seven storms during the 2012 AgI Seeding Cloud Impact Investigation (ASCII-12) campaign in Wyoming. The DOW was located on the Sierra Madre (the target range), with excellent low-level coverage toward the Medicine Bow (the downwind range). To examine the seeding impact, two study areas are designated, both over the foothills of the downwind range: one is directly downwind of the remote silver iodide (AgI) generators (target area), and the other is offset sideways (control area). Comparisons are made between radar reflectivity measurements from a treated period and those from an untreated period. The total treated (untreated) period over seven storms is 14.3 h (21.2 h). Independent measurements of ice nuclei concentrations indicate that ground-released AgI nuclei can disperse across two mountain ranges over a distance of ~80 km. Analyses of DOW transects, DOW echo-height maps, and Doppler velocities from an airborne profiling radar suggest three different mechanisms for the vertical mixing of AgI nuclei: in all cases boundary layer mixing is active, and in some cases convection, or a lee hydraulic jump, or both are present. In all cases the radar reflectivity is higher during seeding in the target region when compared with the trend over the same period in the control region. Note that the results are not definitive proof of a downwind seeding impact since natural variability of precipitation is large and the sample size examined is small.
Air–Sea Interaction in Association with Monthly Anomaly Departure over the Western North Pacific and Tropical Indian Ocean during the Spring-to-Summer Transition
Authors: Hu Wenting , Wu Renguang 
Published: January 2016

Abstract
The study analyzes precipitation variability and related air–sea interaction processes over the South China Sea (SCS) and tropical Indian Ocean (TIO) during the spring-to-summer transition season. It is found that physical processes are very different for the variations of seasonal mean and the monthly departures from the seasonal mean. Corresponding to the seasonal mean anomaly, remote forcing from the equatorial Pacific is a major factor for the precipitation variability with a prominent negative feedback of the atmosphere on the ocean. However, from the viewpoint of the monthly anomaly departure from the seasonal mean, a pronounced local coupled air–sea interaction is detected in both the SCS and TIO that features a sequential process of less rainfall, higher sea surface temperature (SST), more rainfall, and lower SST. The evolution of the SST tendency is well coordinated with that of net surface heat flux in the SCS and TIO. During the transition season, shortwave radiation is a dominant term for the SST change in the SCS, whereas both shortwave radiation and latent heat flux are responsible for the SST change in the TIO. The local air–sea relationship shows an obvious spatiotemporal variation during the transition season. Furthermore, the SST anomaly departure in the TIO (SCS) in April (May) could be considered as an indicator for local precipitation anomaly departure in May (June).
Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study
Authors: Silveira Leonardo E , Bond David J , MacMillan Erin Leigh , Kozicky Jan-Marie , Muralidharan Kesavan , Bücker Joana , Rosa Adriane Ribeiro , Kapczinski Flavio , Yatham Lakshmi N 
Published: January 2016

Objective: Previous studies reported decreased N-acetyl aspartate and increased Glx (the sum of glutamate plus glutamine) in bipolar disorder. Since these studies included patients at different stages of illness, it is unknown whether these changes have a causal role or a consequence of multiple episodes and treatments. The studies in early-stage bipolar disorder patients have the potential to provide answers to these issues. Therefore, we evaluated N-acetyl aspartate and Glx levels in hippocampi of first-episode bipolar disorder patients and health subjects at baseline and at 12 months, and examined the impact of episode recurrence on these measures. Method: We used single-voxel proton magnetic resonance spectroscopy to compare the hippocampal neurometabolites ( N-acetyl aspartate and Glx) levels between 41 patients with bipolar disorder following recovery from their first-manic episode and 27 matched healthy subjects at recruitment and 12 months later. We also compared N-acetyl aspartate and Glx levels between patients who had a recurrence of a mood episode and those who did not. Results: There was no main effect of either group (diagnosis) or time for hippocampal N-acetyl aspartate and Glx levels in bipolar disorder patients and healthy subjects. We also did not find any group-by-time interaction for the levels of these metabolites. There were also no differences in N-acetyl aspartate and Glx between patients who experienced a recurrence of a mood episode and those who did not over 12-month follow-up. Conclusion: Our data suggest that N-acetyl aspartate and Glx levels are not altered in early stage bipolar disorder. Further, these data suggest that episode recurrence in early stages does not have a significant impact on the levels of these metabolites. These may suggest that there may be an early window for intervention to potentially arrest neuroprogression of the disease.
Vanishing calcification associated with a spontaneous ventral spinal cerebrospinal fluid leak
Authors: Schievink Wouter I , Ross Lindsey , Prasad Ravi S , Maya M Marcel 
Published: January 2016

Background Some patients with spontaneous intracranial hypotension have a ventral spinal cerebrospinal fluid (CSF) leak and these CSF leaks may be associated with calcified disk herniations. Identifying these calcifications is helpful in directing treatment. We report here the unusual case of a patient with a ventral CSF leak in whom the associated calcification absorbed over a five-month period. Case report A 42-year-old woman developed orthostatic headaches and bilateral abducens nerve palsies. Magnetic resonance imaging of her brain showed typical findings of spontaneous intracranial hypotension. Magnetic resonance imaging of her spine showed an extensive cervicothoracic CSF leak. Computed tomographic myelography showed calcification at the Th1–2 disk space. Three epidural blood patches were performed, but her symptoms persisted. Digital subtraction myelography performed five months later showed an upper thoracic ventral CSF, but the calcification was no longer present. A dural tear, found at surgery at the Th1–2 level, was repaired and the patient made an uneventful recovery. Discussion The resorption of calcifications at the level of a ventral spinal CSF leak could explain the absence of any calcifications in at least some patients with such leaks and demonstrates the usefulness of reviewing previous imaging in patients with ventral CSF leaks if the exact site of the leak remains unknown.
The Reduction in Stability From Combined Humeral Head and Glenoid Bony Defects Is Influenced by Arm Position
Authors: Walia Piyush , Patel Ronak M. , Gottschalk Lionel , Kuklis Matthew , Jones Morgan H. , Fening Stephen D. , Miniaci Anthony 
Published: January 2016

Background: Combined defects of the glenoid and humeral head are often a cause for recurrent shoulder instability. Purpose/Hypothesis: The aim of this study was to evaluate the influence of combined bony lesions on shoulder instability through varying glenohumeral positions. The hypothesis was that instability due to combined defects would be magnified with increasing abduction and external rotation. Study Design: Controlled laboratory study. Methods: Eighteen cadaveric shoulders were tested. Experiments were performed at combinations of glenohumeral abduction angles of 20°, 40°, and 60° and external rotations of 0°, 40°, and 80°. The various glenoid defect sizes created were 10%, 20%, and 30% of the glenoid width. Four humeral head defects were created based on humeral head diameter (6%, 19%, 31%, and 44%). Each experiment consisted of translating the glenoid in a posterior direction to simulate an anterior dislocation under a 50-N load. The instability was measured as a percentage of intact translation (ie, loss in translational distance normalized to the no-defect condition). Results: At 20° of abduction, instability increased from 100% to 85%, 70%, and 43% with increasing glenoid defect sizes of 10%, 20% and 30%, respectively, with a 6% humeral head defect. However, at a functional arm position of apprehension, these values were significantly decreased ( P < .05) for humeral head defect sizes of 19%, 31%, and 44%, with translation values of 49%, 27%, and 2%, respectively. Conclusion: A humeral defect leads to rotational instability with the arm rotated into a functional position rather than a resting position. However, a significant glenoid defect can lead to loss of translation independent of changes in arm position. Combined defects as large as 44% of humeral head and 20% glenoid did not show instability at 20° of abduction and neutral position; however, defects as small as 19% humeral defect and 10% glenoid defect led to significant instability in the position of apprehension. Clinical Relevance: Instability at lower levels of abduction and external rotation clinically indicates larger bony defects and may need to be directly addressed, depending on the patient’s age and function.