bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in severe lower respiratory symptoms and small airway function in World Trade Center dust exposed community members
Authors: Caplan‐Shaw Caralee , Kazeros Angeliki , Pradhan Deepak , Berger Kenneth , Goldring Roberta , Zhao Sibo , Liu Mengling , Shao Yongzhao , Fernandez‐Beros Maria Elena , Marmor Michael , Levy‐Carrick Nomi , Rosen Rebecca , Ferri Lucia , Reibman Joan 
Published: September 2016

ObjectiveLongitudinal assessment of lower respiratory symptoms (LRS) in community members with World Trade Center (WTC) exposures.MethodsAdult members of a treatment program with complete standardized visits were evaluated (n = 798). Association of demographic characteristics, mental health symptoms and lung function with trajectory of LRS between initial and monitoring visit was evaluated.ResultsSevere LRS were present in 70% at initial and 63% at monitoring visit. Initial severe LRS were associated with WTC dust cloud exposure and mental health symptoms. Spirometry measures were not associated with LRS severity or trajectory; improvement in LRS was associated with improved lung function measured with forced oscillometry techniques.ConclusionMany community patients in a WTC treatment program had severe LRS associated with exposures and mental health symptoms. Improvement in LRS was associated with improvement in measures of small airway function. Am. J. Ind. Med. 59:777–787, 2016. © 2016 Wiley Periodicals, Inc.
Aminopyridinyl–Pseudodeoxycytidine Derivatives Selectively Stabilize Antiparallel Triplex DNA with Multiple CG Inversion Sites
Authors: Okamura Hidenori , Taniguchi Yosuke , Sasaki Shigeki 
Published: September 2016

AbstractThe sequence‐specific formation of triplex DNA offers a potential basis for genome‐targeting technologies. In an antiparallel triplex DNA, the sequence‐specificity is established by the formation of specific base triplets (G−GC, A−AT, and T−AT) between a triplex‐forming oligonucleotide (TFO) and a duplex DNA. However, there are no natural nucleosides that can selectively recognize the inverted CG and TA base pairs. Therefore, the recognition of the CG and TA inversion sites to form a stable triplex DNA has been a long‐standing goal for the triplex‐forming technology. We now describe the design and synthesis of pseudo‐deoxycytidine (ΨdC) derivatives for selective recognition of the CG base pair to expand the triplex‐forming sequence. The aminopyridine‐bearing ΨdC derivatives showed high selectivity and affinity toward the CG base pair in all neighboring base contexts. Remarkably, 3‐methyl‐2‐aminopyridinyl−ΨdC (MeAP−ΨdC) formed a stable triplex with the promoter sequence of the hTERT gene containing four CG inversion sites, and effectively inhibited its transcription in human cancer cells. Thus, MeAP−ΨdC is expected to serve as a new starting point of triplex‐forming oligonucleotides for a wide variety of genome‐targeting applications.
Preparation and characterization of a polydimethylsiloxane‐modified, epoxy‐resin‐based polyol dispersion and its crosslinked films
Authors: Liu Di , Wu Guo‐Min , Kong Zhen‐Wu 
Published: September 2016

ABSTRACTWaterborne polydimethylsiloxane‐modified epoxy‐resin‐based polyol dispersions were synthesized by the reaction of 2,4‐toluene diisocyanate with 2,2‐bis(hydroxymethyl) propionic acid, hydroxypropyl‐terminated polydimethylsiloxane (HTPDMS), and bisphenol A epoxy resin based polyol. These HTPDMS‐modified polyol dispersions exhibited a small particle size and an excellent dispersion stability. Two‐component waterborne polyurethane (2K‐WPU) was prepared from the HTPDMS‐modified polyol dispersion and a hydrophilic‐modified polyisocyanate. The structure of the HTPDMS‐modified polyol and its crosslinked 2K‐WPU films (SEFs) were characterized with Fourier transform infrared and NMR spectroscopies. The effects of the HTPDMS content on the mechanical and thermal properties of the resulting SEFs were investigated. The results show that the thermal stability of the crosslinked SEFs was enhanced with increasing HTPDMS content, whereas the modulus, tensile strength, and pencil hardness values of the films decreased with increasing HTPDMS content. Siloxane segments migrated onto the surface during the film‐formation process. The contact angle of the films increased from 71 to 96 °, and the water absorption ratio of the films decreased from 6.6 to 5.0% when the HTPDMS content in the films increased from 0 to 10%. These results indicate that the water resistance of the films was enhanced by the introduction of HTPDMS into the 2K‐WPU networks. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44342.
Evaluation of bioresorbable polymers as potential stent material—In vivo degradation behavior and histocompatibility
Authors: Liao Lan , Peng Cheng , Li Suming , Lu Zhiqian , Fan Zhongyong 
Published: September 2016

ABSTRACTA PLLA‐TMC‐GA terpolymer of 90/5/5 molar ratio was synthesized by ring‐opening polymerization of l‐lactide (LLA), trimethylene carbonate (TMC), and glycolide (GA), using stannous octoate as initiator. In vivo degradation of the obtained terpolymer and a composite made up of the terpolymer matrix reinforced by PLLA‐GA fibers was realized by subcutaneous implantation in rats for 9 months, in comparison with PLLA homopolymer and PLLA‐TMC copolymer of 95/5 molar ratio. The terpolymer shows ideal degradation profile because it is expected to maintain relatively high radial support for 3 months and lose its mechanical properties in 3 to 6 months inferred from molar mass changes. Increase of crystallinity and LLA content in the terpolymer and composite is observed during degradation. According to the gross observation and H&E staining appearance, all samples present good tissue compatibility. These results suggest that the terpolymer is promising for uses as fully biodegradable vascular scaffold. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44355.
Mechanical properties of individual fiber segments of electrospun lignocellulose‐reinforced poly(vinyl alcohol)
Authors: Šutka Anna , Antsov Mikk , Järvekülg Martin , Visnapuu Meeri , Heinmaa Ivo , Mäeorg Uno , Vlassov Sergei , Šutka Andris 
Published: September 2016

ABSTRACTThe influence of lignocellulosic nanofibers (LCNF) additive on the inherent mechanical properties of submicron electrospun poly(vinyl alcohol) (PVA) fibers is reported. LCNF with a diameter of 25 ± 15 nm and a length of 220 ± 90 nm obtained from hemp shives were dispersed in aqueous PVA solutions to produce homogeneous nanocomposite fibers with 0, 5, and 10 w/w % LCNF loads in solid PVA. Tensile tests on mats show that LCNF additive causes up to sevenfold increase in stiffness and significant decrease in elongation at yield. AFM‐based 3‐point bending tests on single LCNF‐doped fibers reveal up to 11.4 GPa Young's modulus in the diameter range of 300 to 500 nm, indicating a 2.4 times increase compared to neat PVA fibers. Mechanical properties of both neat and LCNF‐doped PVA fibers are found to be strongly size‐dependent at lower fiber diameters, with Young's modulus values exceeding 100 GPa at below 100 nm diameters. The results can be explained by extensive restructuration of hydrogen bonding network due to the LCNF additive. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44361.
Classification and speed estimation of vehicles via tire detection using single‐element piezoelectric sensor
Authors: Rajab Samer , Al Kalaa Mohamad O. , Refai Hazem 
Published: September 2016

SummaryThis paper presents novel vehicle classification technology by utilizing a single‐element piezoelectric sensor placed diagonally on a traffic lane to accurately identify vehicles. Novelty of this technique originates from using diagonally placed piezoelectric strip sensor and machine learning technology to provide a highly accurate and cost‐effective alternative to current vehicle classification systems. Diagonal placements of the piezoelectric strip sensor ensure detection of passing vehicle tires by facilitating vehicle classification process. Presented technology is capable of accurately classifying vehicles into a relatively large number of classifications, including motorcycle, which has proven to be a challenging category in present‐day commercial vehicle classifiers. Vehicle classification is a vital intelligent transportation systems application. Accurate data reporting aids suitable roadway design for safety and capacity and can also support other purposes, such as reporting highway congestion to the general public or providing area denseness data to interested businesses.To make a classification decision, a vehicle's signal is acquired from diagonal piezoelectric strip sensor, processed, and then applied to a machine learning algorithm. A speed estimation technique using the same single‐element piezoelectric sensor was also developed, tested, and compared with an embedded vehicle classifier currently used by the Oklahoma Department of Transportation. Testing on several highway sites indicated up to 97% classification accuracy. This paper presents a complete description of the developed system, including sensor installation, data acquisition and processing, and classification algorithm. Overall, the system offers a high‐performance cost‐effective solution for vehicle classification that minimizes roadwork typically required for loop and sensor installations of current systems. Copyright © 2016 John Wiley & Sons, Ltd.
Efficient solution algorithm for finding spatially dependent reliable shortest path in road networks
Authors: Chen Bi Yu , Lam William H. K. , Li Qingquan 
Published: September 2016

SummaryTravel times are generally stochastic and spatially correlated in congested road networks. However, very few existing route guidance systems (RGS) can provide reliable guidance services to aid travellers planning their trips with taking account explicitly travel time reliability constraint. This study aims to develop such a RGS with particular consideration of travellers' concern on travel time reliability in congested road networks with uncertainty. In this study, the spatially dependent reliable shortest path problem (SD‐RSPP) is formulated as a multi‐criteria shortest path‐finding problem in road networks with correlated link travel times. Three effective dominance conditions are established for links with different levels of travel time correlations. An efficient algorithm is proposed to solve SD‐RSPP by adaptively using three established dominance conditions. The complexities of road networks in reality are also explicitly considered. To demonstrate the applicability of proposed algorithm, a comprehensive case study is carried out in Hong Kong. The results of case study show that the proposed solution algorithm is robust to take account of travellers' multiple routing criteria. Computational results demonstrate that the proposed solution algorithm can determine the reliable shortest path on real‐time basis for large‐scale road networks. Copyright © 2016 John Wiley & Sons, Ltd.
Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β‐catenin signaling cascades and reversal of epithelial–mesenchymal transition
Authors: Shrivastava Shweta , Jeengar Manish Kumar , Thummuri Dinesh , Koval Alexey , Katanaev Vladimir L. , Marepally Srujan , Naidu V.G.M. 
Published: September 2016

AbstractCardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of CD for the treatment of triple negative breast cancer (TNBC) is unclear. This study aims to examine the cytotoxic effects of CD and investigate the underlying mechanism in human TNBC cells. The results show that CD exhibits cytotoxicity by inducing apoptosis and cell cycle arrest in TNBC cells via modulation of Bcl‐2, Bax, cyt‐C, cleaved caspase‐3, and PARP. We find that CD significantly increases expression of the epithelial marker E‐cadherin, while reciprocally decreasing expression of mesenchymal markers such as snail, slug, and vimentin in BT‐549 cells. In parallel with epithelial–mesenchymal transition (EMT) reversal, CD down regulates invasion and migration of BT‐549 cells. CD markedly reduces stability and nuclear translocation of β‐catenin, accompanied with downregulation of β‐catenin target genes. Using the TopFlash luciferase reporter assay, we reveal CD as a specific inhibitor of the Wnt3a‐induced signaling. These results suggest the involvement of the Wnt/β‐catenin signaling in the CD‐induced EMT reversion of BT‐549 cells. Notably, CD restores the glycogen synthase kinase‐3β (GSK3β) activity, required for β‐catenin destruction via the proteasome‐mediated system, by inhibiting the phosphorylation of GSK3β by Akt. These occurrences ultimately lead to the blockage of EMT and the invasion of TNBC cells. Further antitumor activity of CD was tested in 4T1 (TNBC cells) induced tumor and it was found that CD significantly inhibited the tumor volume at dose of 5 mg/kg‐treated mice. © 2016 BioFactors, 43(2):152–169, 2017
Nutrigenomics of extra‐virgin olive oil: A review
Authors: Piroddi Marta , Albini Adriana , Fabiani Roberto , Giovannelli Lisa , Luceri Cristina , Natella Fausta , Rosignoli Patrizia , Rossi Teresa , Taticchi Agnese , Servili Maurizio , Galli Francesco 
Published: September 2016

AbstractNutrigenomics data on the functional components of olive oil are still sparse, but rapidly increasing. Olive oil is the main source of fat and health‐promoting component of the Mediterranean diet. Positive effects have been observed on genes involved in the pathobiology of most prevalent age‐ and lifestyle‐related human conditions, such as cancer, cardiovascular disease and neurodegeneration. Other effects on health‐promoting genes have been identified for bioactive components of olives and olive leafs. Omics technologies are offering unique opportunities to identify nutritional and health biomarkers associated with these gene responses, the use of which in personalized and even predictive protocols of investigation, is a main breakthrough in modern medicine and nutrition. Gene regulation properties of the functional components of olive oil, such as oleic acid, biophenols and vitamin E, point to a role for these molecules as natural homeostatic and even hormetic factors with applications as prevention agents in conditions of premature and pathologic aging. Therapeutic applications can be foreseen in conditions of chronic inflammation, and particularly in cancer, which will be discussed in detail in this review paper as major clinical target of nutritional interventions with olive oil and its functional components. © 2016 BioFactors, 43(1):17–41, 2017
Engineering responsive supramolecular biomaterials: Toward smart therapeutics
Authors: Webber Matthew J. 
Published: September 2016

AbstractEngineering materials using supramolecular principles enables generalizable and modular platforms that have tunable chemical, mechanical, and biological properties. Applying this bottom‐up, molecular engineering‐based approach to therapeutic design affords unmatched control of emergent properties and functionalities. In preparing responsive materials for biomedical applications, the dynamic character of typical supramolecular interactions facilitates systems that can more rapidly sense and respond to specific stimuli through a fundamental change in material properties or characteristics, as compared to cases where covalent bonds must be overcome. Several supramolecular motifs have been evaluated toward the preparation of “smart” materials capable of sensing and responding to stimuli. Triggers of interest in designing materials for therapeutic use include applied external fields, environmental changes, biological actuators, applied mechanical loading, and modulation of relative binding affinities. In addition, multistimuli‐responsive routes can be realized that capture combinations of triggers for increased functionality. In sum, supramolecular engineering offers a highly functional strategy to prepare responsive materials. Future development and refinement of these approaches will improve precision in material formation and responsiveness, seek dynamic reciprocity in interactions with living biological systems, and improve spatiotemporal sensing of disease for better therapeutic deployment.
Metal‐Promoted Coupling Reactions Implying Ligand‐Based Redox Changes
Authors: Jacquet Jérémy , Desage‐El Murr Marine , Fensterbank Louis 
Published: September 2016

AbstractCoupling reactions are staples in the synthetic world and their efficiency relies on well‐defined, mostly bis‐electronic, elementary catalytic steps. An area of great interest currently lies in the taming of radical species and their efficient introduction in catalytic cycles. Among these species bearing radical character, redox‐active ligands hold much potential and can be used to sustain synthetically relevant couplings by introducing ligand‐based electronic contribution. This minireview aims at presenting the current state of this promising field.
A Convenient Synthesis of 1,2,4‐ and 1,3,4‐Azadiphospholes
Authors: Suter Riccardo , Benkő Zoltán , Grützmacher Hansjörg 
Published: August 2016

AbstractA new synthetic route to functionalized neutral and anionic azadiphospholes from easily accessible starting materials is described. Equimolar reaction of Na(OCP) and N‐(2,6‐dimethylphenyl)pivalimidoyl chloride 2 a cleanly affords the imidoxy‐functionalized 1,2,4‐azadiphosphole 3 a. Using Na(OCP) and imidoyl chloride in a 2:1 ratio leads to an anionic four‐membered ring Na[4 a], which has been structurally characterized. During 16 h at room temperature, Na[4 a] rearranges to the anionic 1,3,4‐azadiphospholide Na[5 a] with release of carbon monoxide. Applying the more sterically demanding N‐(2,6‐diisopropylphenyl)pivalimidoyl chloride allows isolation of the 1,3,4‐azadiphospholide Na[5 b] in good yield (>70 %). Possible mechanisms leading to the new isomeric azadiphospholides have been investigated with the aid of high‐level composite calculations.
Carbon Dioxide to Methanol: The Aqueous Catalytic Way at Room Temperature
Authors: Sordakis Katerina , Tsurusaki Akihiro , Iguchi Masayuki , Kawanami Hajime , Himeda Yuichiro , Laurenczy Gábor 
Published: September 2016

AbstractCarbon dioxide may constitute a source of chemicals and fuels if efficient and renewable processes are developed that directly utilize it as feedstock. Two of its reduction products are formic acid and methanol, which have also been proposed as liquid organic chemical carriers in sustainable hydrogen storage. Here we report that both the hydrogenation of carbon dioxide to formic acid and the disproportionation of formic acid into methanol can be realized at ambient temperature and in aqueous, acidic solution, with an iridium catalyst. The formic acid yield is maximized in water without additives, while acidification results in complete (98 %) and selective (96 %) formic acid disproportionation into methanol. These promising features in combination with the low reaction temperatures and the absence of organic solvents and additives are relevant for a sustainable hydrogen/methanol economy.
ChemInform Abstract: Phase Change of Gallium Enables Highly Reversible and Switchable Adhesion.
Authors: Ye Zhou , Lum Guo Zhan , Song Sukho , Rich Steven , Sitti Metin 
Published: September 2016

AbstractElastomer posts (PDMS, 0.5—1.75 mm diameter) are dip‐coated with liquid Ga (34 °C, 8.3 kPa preload pressure to break the oxide layer) followed by solidifying the Ga layer and formation of a new oxide layer on the Ga droplet in air.
ChemInform Abstract: The Effect of Indium Substitution on the Structure and NLO Properties of Ba6Cs2Ga10Se20Cl4.
Authors: Li Yan‐Yan , Liu Peng‐Fei , Lin Hua , Wang Mei‐Tian , Chen Ling 
Published: September 2016

AbstractSingle crystals of Ba6Cs2InxGa10‐xSe20 Cl4 with x = 2 (I) and 1 (II) are prepared by solid state reaction of stoichiometric amounts of CsCl, BaCl2, Ba, In, Ga, and Se (graphite crucible in evacuated silica tubes, 1172 K, 100 h).
ChemInform Abstract: Structure, Magnetic and Magnetocaloric Properties of New Nanocrystalline (Pr,Dy)Fe9 Compounds.
Authors: Guetari R. , Bartoli T. , Cizmas C. B. , Mliki N. , Bessais L. 
Published: September 2016

AbstractIn the view of magnetic refrigeration, the nanostructured pseudobinary alloy samples Pr1‐xDyxFe9 (x = 0.0625, 0.125, 0.1875, 0.25) are prepared by high‐energy ball milling of the elements under Ar (5 h) followed by short annealing (Ta foil in evacuated silica tubes, 500—1100 °C, 30 min).
ChemInform Abstract: Intrinsic Photocatalytic Water Reduction over PbGaBO4 Comprising Edge‐Sharing GaO6 Chains.
Authors: Song Kai , Yue Mufei , Gao Wenliang , Cong Rihong , Yang Tao 
Published: September 2016

AbstractPolycrystalline PbGaBO4 is prepared by solid state reaction of a 1:1:1.1 molar mixture of PbCO3, Ga2O3, and H3BO3 (600 °C, 25 h) and by dissolving Ga2O3 in conc.
ChemInform Abstract: Facile Hydrazine‐Hydrothermal Syntheses and Characterizations of Two Quaternary Thioarsenates(III): Two‐Dimensional SrAg4As2S6·2 H2O and One‐Dimensional BaAgAsS3.
Authors: Yan Dongming , Liu Chang , Chai Wenxiang , Zheng Xuerong , Zhang Luodong , Zhi Mingjia , Zhou Chunmei , Zhang Qichun , Liu Yi 
Published: September 2016

AbstractSingle crystals of SrAg4As2S6·2H2O (I) and BaAgAsS3 (II) are grown by hydrazine‐hydrothermal reaction of a 3:1:0.5:4 molar mixture of Sr(OH)2 or Ba(OH)2, Ag, As2S3, and S in N2H4·H2O (autoclave, 160 °C, 7 d, 40% and 50% yield, resp.).
ChemInform Abstract: Enantioselective Synthesis of 10‐Allylanthrones via Iridium‐Catalyzed Allylic Substitution Reaction.
Authors: Zhao Zheng‐Le , Gu Qing , Wu Xin‐Yan , You Shu‐Li 
Published: September 2016

AbstractThe title reaction proceeds under very mild reaction conditions and can provide various substituted 10‐allylanthrones in excellent yields and excellent chemo‐, regio‐, and enantioselectivities.
ChemInform Abstract: Artificial Diels—Alderase Based on the Transmembrane Protein FhuA.
Authors: Osseili Hassan , Sauer Daniel F , Beckerle Klaus , Arlt Marcus , Himiyama Tomoki , Polen Tino , Onoda Akira , Schwaneberg Ulrich , Hayashi Takashi , Okuda Jun 
Published: September 2016

AbstractNewly prepared copper complexes covalently linked to an engineered variant of ferric hydroxamate uptake protein component A are biohybrid catalysts for the Diels—Alder reaction of a chalcone with cyclopentadiene to give the corresponding endo product.
ChemInform Abstract: Dehydrogenative [2 + 2 + 1] Heteroannulation Using a Methyl Group as a One‐Carbon Unit: Access to Pyrazolo[3,4‐c]quinolines.
Authors: Deng Guo‐Bo , Li Hai‐Bing , Yang Xu‐Heng , Song Ren‐Jie , Hu Ming , Li Jin‐Heng 
Published: September 2016

AbstractThe operationally simple title reaction between N‐(o‐alkenylaryl)imines and aryldiazonium tetrafluoroborates tolerates various functional groups.
ChemInform Abstract: Photoinduced Formation of Hybrid Aryl Pd‐Radical Species Capable of 1,5‐HAT: Selective Catalytic Oxidation of Silyl Ethers into Silyl Enol Ethers.
Authors: Parasram Marvin , Chuentragool Padon , Sarkar Dhruba , Gevorgyan Vladimir 
Published: September 2016

AbstractAn unprecedented hydrogen atom transfer event for hybrid Pd‐radical species is reported.
ChemInform Abstract: Trimethylchlorosilane‐Mediated Mild α‐Chlorination of 1,3‐Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate.
Authors: Chong Siying , Su Yingpeng , Wu Lili , Zhang Weigang , Ma Junyan , Chen Xiaowei , Huang Danfeng , Wang Ke‐Hu , Hu Yulai 
Published: September 2016

AbstractTMSBr as reagent gives the corresponding bromides in similar yields.
ChemInform Abstract: Trihaloisocyanuric Acid/Triphenylphosphine: An Efficient System for Regioselective Conversion of Epoxides into Vicinal Halohydrins and Vicinal Dihalides under Mild Conditions.
Authors: de Andrade Vitor S. C. , de Mattos Marcio C. S. 
Published: September 2016

AbstractTribromoisocyanuric acid gives the corresponding bromo compounds in similar yields.