bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annually resolved late Holocene paleohydrology of the southern Sierra Nevada and Tulare Lake, California
Authors: Adams Kenneth D. , Negrini Robert M. , Cook Edward R. , Rajagopal Seshadri 
Published: November 2015

AbstractHere we present 2000 year long, annually resolved records of streamflow for the Kings, Kaweah, Tule, and Kern Rivers in the southwestern Sierra Nevada of California and consequent lake‐level fluctuations at Tulare Lake in the southern San Joaquin Valley. The integrated approach of using moisture‐sensitive tree ring records from the Living Blended Drought Atlas to reconstruct annual discharge and then routing this discharge to an annual Tulare Lake water balance model highlights the differences between these two types of paleoclimate records, even when subject to the same forcing factors. The reconstructed streamflow in the southern Sierra responded to yearly changes in precipitation and expressed a strong periodicity in the 2–8 year range over most of the reconstruction. The storage capacity of Tulare Lake caused it to fluctuate more slowly, masking the 2–8 year streamflow periodicity and instead expressing a strong periodicity in the 32–64 year range over much of the record. Although there have been longer droughts, the 2015 water year represents the driest in the last 2015 years and the 2012–2015 drought represents the driest 4 year period in the record. Under natural conditions, simulated Tulare Lake levels would now be at about 60 m, which is not as low as what occurred multiple times over the last 2000 years. This long‐term perspective of fluctuations in climate and water supply suggests that different drought scenarios that vary in terms of severity and duration can produce similar lake‐level responses in closed lake basins.
Treatment outcomes, quality of life, and impact of hemophilia on young adults (aged 18–30 years) with hemophilia
Authors: Witkop Michelle , Guelcher Christine , Forsyth Angela , Hawk Sarah , Curtis Randall , Kelley Laureen , Frick Neil , Rice Michelle , Rosu Gabriela , Cooper David L. 
Published: November 2015

The Hemophilia Experiences, Results and Opportunities (HERO) initiative assessed psychosocial issues reported by people with moderate to severe hemophilia and was led by a multidisciplinary international advisory board. This analysis reports data from young adult respondents (aged 18–30 years), including both US and overall global (including US respondents) results, and investigates treatment outcomes, quality of life, and impacts of hemophilia on relationships. More young adults in HERO received prophylaxis than on‐demand treatment, although a majority reported not using factor products exactly as prescribed, and 50% of global respondents and 26% of US respondents reported issues with access to factor replacement therapy in the previous 5 years. Many young adults with hemophilia reported comorbidities, including bone/skeletal arthritis, chronic pain, and viral infections, and nearly half of young adults reported anxiety/depression. Most reported pain interference with daily activities in the past 4 weeks, although a majority reported participating in lower‐risk activities and approximately half in intermediate‐risk activities. Most young adults were very or quite satisfied with the support of partners/spouses, family, and friends, although roughly one‐third reported that hemophilia affected their ability to develop close relationships with a partner. A majority of young adults reported that hemophilia has had a negative impact on employment, and 62% of global respondents and 78% of US respondents were employed at least part‐time. Together these data highlight the psychosocial issues experienced by young adults with hemophilia and suggest that increased focus on these issues may improve comprehensive care during the transition to adulthood. Am. J. Hematol. 90:S3–S10, 2015. © 2015 Wiley Periodicals, Inc.
Effects of aging on the adhesive properties of poly(lactic acid) by atmospheric air plasma treatment
Authors: Jordá‐Vilaplana A. , Sánchez‐Nácher L. , García‐Sanoguera D. , Carbonell A. , Ferri J. M. 
Published: November 2015

ABSTRACTThe aim of this study was to analyze the durability of a plasma treatment on the surface of poly(lactic acid) (PLA). We used atmospheric‐plasma treatment with air to improve the wettability of PLA by evaluating the aging effect under controlled conditions of relative humidity (RH) and temperature (25% RH and 25°C). We studied the durability of the atmospheric‐plasma treatment by measuring the contact angle, calculating the surface energy, and observing changes in the resistance of the PLA–PLA adhesive bonds. These techniques allowed us to evaluate the hydrophobic recovery phenomenon that the PLA surface suffered as a consequence of the aging process. The results provide the maximum storage time of PLA treated with atmospheric plasma at which the sample retained its good adhesion properties; this time was lower than 3 days under normal atmospheric conditions. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43040.
Metabolic engineering of Corynebacterium glutamicum for efficient production of 5‐aminolevulinic acid
Authors: Feng Lili , Zhang Ya , Fu Jing , Mao Yufeng , Chen Tao , Zhao Xueming , Wang Zhiwen 
Published: November 2015

ABSTRACT5‐Aminolevulinic acid (5‐ALA) has recently attracted attention for its potential applications in the fields of medicine and agriculture. In this study, Corynebacterium glutamicum was firstly engineered for 5‐ALA production via the C4 pathway. HemA encoding 5‐aminolevulinic acid synthase from Rhodobacter sphaeroides was codon optimized and expressed in C. glutamicum ATCC13032, resulting in accumulation of 5‐ALA. Deletion of all known genes responsible for the formation of acetate and lactate further enhanced production of 5‐ALA. Overexpression of ppc gene encoding phoenolpyruvate carboxylase resulted in an accumulation of 5‐ALA up to 2.06 ± 0.05 g/L. Furthermore, deletion of high‐molecular‐weight penicillin‐binding proteins (HMW‐PBPs) genes pbp1a, pbp1b, and pbp2b led to an increase in 5‐ALA production of 13.53%, 29.47%, and 22.22%, respectively. Finally, 5‐ALA production was enhanced to 3.14 ± 0.02 g/L in shake flask by heterologously expressing rhtA encoding threonine/homoserine exporter, and 86.77% of supplemented glycine was channeled toward 5‐ALA production in shake flask. The engineered C. glutamicum ALA7 strain produced 7.53 g/L 5‐ALA in a 5 L bioreactor. This study demonstrated the potential utility of C. glutamicum as a platform for metabolic production of 5‐ALA. Change of cell permeability by metabolic engineering HMW‐PBPs may provide a new strategy for biochemicals production in Corynebacterium glutamicum. Biotechnol. Bioeng. 2016;113: 1284–1293. © 2015 Wiley Periodicals, Inc.
Complications during retrograde approach for chronic coronary total occlusion: Sub‐analysis of Japanese multicenter registry
Authors: Okamura Atsunori , Yamane Masahisa , Muto Makoto , Matsubara Tetsuo , Igarashi Yasumi , Nakamura Shigeru , Muramatsu Toshiya , Fujita Tsutomu , Oida Akitsugu , Tsuchikane Etsuo 
Published: November 2015

ObjectivesThis study was performed to determine the complications occurring during retrograde percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) based on analysis of the multicenter, prospective, nonrandomized Retrograde Summit registry.BackgroundRetrograde PCI for CTO has improved treatment success rates, but several complications related to the retrograde approach have been reported, including collateral channel injury and donor artery injury due to their use as retrograde roots.MethodsThis registry included data from 1,166 patients who underwent retrograde PCI for CTO in 28 Japanese centers between January 2009 and December 2011.ResultsOverall procedure success and retrograde procedure success were achieved in 985 (84.5%) and 838 (71.9%) of the 1,166 patients, respectively. In‐hospital major adverse cardiac and cerebrovascular events (MACCE) occurred in 18 (1.5%) of the 1,166 patients. With regard to complications related to the retrograde approach, channel injury occurred in 111 (9.5%) of the 1,166 patients, but treatment was required in only 24 (2.1%) patients and subsequent cardiac tamponade occurred in only 4 (0.3%) patients. Donor artery problems occurred in only 10 (0.9%) of the 1,166 patients. In sub‐analysis regarding the types of collateral channels, the septal channel was significantly safer than epicardial channel because of the lower frequency of non‐Q‐wave myocardial infarction (non‐QMI) and channel injury requiring treatment.ConclusionsThe MACCE rate during retrograde PCI for CTO determined from the Retrograde Summit registry was low and the frequency of complications related to the retrograde approach was acceptable. © 2015 Wiley Periodicals, Inc.
A Bifunctional Nano‐Electrocatalyst Based on a Flower‐Like Gold/Palladium Bimetallic Alloy Nanostructure and Its Graphene Hybrid
Authors: Sahu Subash Chandra , Satpati Biswarup , Besra Laxmidhar , Jena Bikash Kumar 
Published: November 2015

AbstractThe front cover artwork for Issue 24/2015 is provided by the CSIR‐Institute of Minerals and Materials Technology in collaboration with the Saha Institute of Nuclear Physics. The image shows the high performance of a flower‐like Au–Pd alloy nanostructure and its graphene hybrids as bifunctional electrocatalysts towards the oxidation of methanol and reduction of oxygen for fuel applications. See the Full Paper itself at http://dx.doi.org/10.1002/cctc.201500465.
From Dark to Light to Fluorescence Resonance Energy Transfer (FRET): Polarity‐Sensitive Aggregation‐Induced Emission (AIE)‐Active Tetraphenylethene‐Fused BODIPY Dyes with a Very Large Pseudo‐Stokes Shift
Authors: Şen Esra , Meral Kadem , Atılgan Serdar 
Published: November 2015

AbstractThe work presented herein is devoted to the fabrication of large Stokes shift dyes in both organic and aqueous media by combining dark resonance energy transfer (DRET) and fluorescence resonance energy transfer (FRET) in one donor–acceptor system. In this respect, a series of donor–acceptor architectures of 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY) dyes substituted by one, two, or three tetraphenylethene (TPE) luminogens were designed and synthesised. The photophysical properties of these three chromophore systems were studied to provide insight into the nature of donor–acceptor interactions in both THF and aqueous media. Because the generation of emissive TPE donor(s) is strongly polarity dependent, due to its aggregation‐induced emission (AIE) feature, one might expect the formation of appreciable fluorescence emission intensity with a very large pseudo‐Stokes shift in aqueous media when considering FRET process. Interestingly, similar results were also recorded in THF for the chromophore systems, although the TPE fragment(s) of the dyes are non‐emissive. The explanation for this photophysical behaviour lies in the DRET. This is the first report on combining two energy‐transfer processes, namely, FRET and DRET, in one polarity‐sensitive donor–acceptor pair system. The accuracy of the dark‐emissive donor property of the TPE luminogen is also presented for the first time as a new feature for AIE phenomena.
Structural Effects in Visible‐Light‐Responsive Metal–Organic Frameworks Incorporating ortho‐Fluoroazobenzenes
Authors: Castellanos Sonia , Goulet‐Hanssens Alexis , Zhao Fangli , Dikhtiarenko Alla , Pustovarenko Alexey , Hecht Stefan , Gascon Jorge , Kapteijn Freek , Bléger David 
Published: November 2015

AbstractThe ability to control the interplay of materials with low‐energy photons is important as visible light offers several appealing features compared to ultraviolet radiation (less damaging, more selective, predominant in the solar spectrum, possibility to increase the penetration depth). Two different metal–organic frameworks (MOFs) were synthesized from the same linker bearing all‐visible ortho‐fluoroazobenzene photoswitches as pendant groups. The MOFs exhibit different architectures that strongly influence the ability of the azobenzenes to isomerize inside the voids. The framework built with Al‐based nodes has congested 1D channels that preclude efficient isomerization. As a result, local light–heat conversion can be used to alter the CO2 adsorption capacity of the material on exposure to green light. The second framework, built with Zr nodes, provides enough room for the photoswitches to isomerize, which leads to a unique bistable photochromic MOF that readily responds to blue and green light. The superiority of green over UV irradiation was additionally demonstrated by reflectance spectroscopy and analysis of digested samples. This material offers promising perspectives for liquid‐phase applications such as light‐controlled catalysis and adsorptive separation.
Exquisite 1D Assemblies Arising from Rationally Designed Asymmetric Donor–Acceptor Architectures Exhibiting Aggregation‐Induced Emission as a Function of Auxiliary Acceptor Strength
Authors: Singh Roop Shikha , Mukhopadhyay Sujay , Biswas Arnab , Pandey Daya Shankar 
Published: November 2015

AbstractOne‐dimensional nanostructures with aggregation‐induced emission (AIE) properties have been fabricated to keep the pace with growing demand from optoelectronics applications. The compounds 2‐[4‐(4‐methylpiperazin‐1‐yl)benzylidene]malononitrile (PM1), 2‐{4‐[4‐(pyridin‐2‐yl)piperazin‐1‐yl]‐benzylidene}malononitrile (PM2), and 2‐{4‐[4‐(pyrimidin‐2‐yl)piperazin‐1‐yl]benzylidene}malononitrile (PM3) have been designed and synthesized by melding piperazine and dicyanovinylene to investigate AIE in an asymmetric donor–acceptor (D–A) construct of A′–D–π–A‐ topology. The synthetic route has been simplified by using phenylpiperazine as a weak donor (D), dicyanovinylene as an acceptor (A), and pyridyl/pyrimidyl groups (PM2/PM3) as auxiliary acceptors (A′). It has been established that A′ plays a vital role in triggering AIE in these compounds because the same D–A construct led to aggregation‐caused quenching upon replacing A′ with an electron‐donating ethyl group (PM1). Moreover, the effect of restricted intramolecular rotation and twisted intramolecular charge transfer on the mechanism of AIE has also been investigated. Furthermore, it has been clearly shown that the optical disparities of these A′–D–π–A architectures are a direct consequence of comparative A′ strength. Single‐crystal X‐ray analyses provided justification for role of intermolecular interactions in aggregate morphology. Electrochemical and theoretical studies affirmed the effect of the A′ strength on the overall properties of the A′–D–π–A system.
Symmetry‐Driven Strategy for the Assembly of the Core Tetracycle of (+)‐Ryanodine: Synthetic Utility of a Cobalt‐Catalyzed Olefin Oxidation and α‐Alkoxy Bridgehead Radical Reaction
Authors: Nagatomo Masanori , Hagiwara Koji , Masuda Kengo , Koshimizu Masaki , Kawamata Takahiro , Matsui Yuki , Urabe Daisuke , Inoue Masayuki 
Published: November 2015

AbstractRyanodine (1) is a potent modulator of intracellular calcium release channels, designated as ryanodine receptors. The exceptionally complex molecular architecture of 1 comprises a highly oxygenated pentacyclic system with eleven contiguous stereogenic centers, which makes it a formidable target for organic synthesis. We identified the embedded C2‐symmetric tricyclic substructure within 1. This specific recognition permitted us to design a concise synthetic route to enantiopure tricycle 9 by utilizing a series of pairwise functionalizations. The four tetrasubstituted carbon centers of 9 were effectively constructed by three key reactions, a dearomatizing Diels–Alder reaction, the kinetic resolution of the obtained racemic 14 through asymmetric methanolysis, and the transannular aldol reaction of the eight‐membered diketone 10. A new combination of cobalt‐catalyzed hydroperoxidation and NfF‐promoted elimination enabled conversion of the hindered olefin of 9 into the corresponding ketone, thus realizing the desymmetrization. Finally, the tetrasubstituted carbon was stereospecifically installed by utilizing the α‐alkoxy bridgehead radical to deliver the core tetracycle 7 with the six contiguous tetrasubstituted carbon centers. Consequently, the present work not only accomplishes efficient assembly of four out of the five fused rings of 1, but also develops two new powerful methodologies: two‐step ketone formation and bridgehead radical reaction.
Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI
Authors: Li Jikun , Feng Xinxin , Zhu Wei , Oskolkov Nikita , Zhou Tianhui , Kim Boo Kyung , Baig Noman , McMahon Michael T. , Oldfield Eric 
Published: November 2015

AbstractDiamagnetic chemical exchange saturation transfer (CEST) contrast agents offer an alternative to Gd3+‐based contrast agents for MRI. They are characterized by containing protons that can rapidly exchange with water and it is advantageous to have these protons resonate in a spectral window that is far removed from water. Herein, we report the first results of DFT calculations of the 1H nuclear magnetic shieldings in 41 CEST agents, finding that the experimental shifts can be well predicted (R2=0.882). We tested a subset of compounds with the best MRI properties for toxicity and for activity as uncouplers, then obtained mice kidney CEST MRI images for three of the most promising leads finding 16 (2,4‐dihydroxybenzoic acid) to be one of the most promising CEST MRI contrast agents to date. Overall, the results are of interest since they show that 1H NMR shifts for CEST agents—charged species—can be well predicted, and that several leads have low toxicity and yield good in vivo MR images.
Synergistic Ternary Composite (Carbon/Fe3O4@Graphene) with Hollow Microspherical and Robust Structure for Li‐Ion Storage
Authors: Li Xingxing , Zheng Xueying , Shao Jie , Gao Tian , Shi Qiang , Qu Qunting 
Published: November 2015

AbstractThe electrode materials with hollow structure and/or graphene coating are expected to exhibit outstanding electrochemical performances in energy‐storage systems. 2D graphene‐wrapped hollow C/Fe3O4 microspheres are rationally designed and fabricated by a novel facile and scalable strategy. The core@double‐shell structure SPS@FeOOH@GO (SPS: sulfonated polystyrene, GO: graphene oxide) microspheres are first prepared through a simple one‐pot approach and then transformed into C/Fe3O4@G (G: graphene) after calcination at 500 °C in Ar. During calcination, the Kirkendall effect resulting from the diffusion/reaction of SPS‐derived carbon and FeOOH leads to the formation of hollow structure carbon with Fe3O4 nanoparticles embedded in it. In the rationally constructed architecture of C/Fe3O4@G, the strongly coupled C/Fe3O4 hollow microspheres are further anchored onto 2D graphene networks, achieving a strong synergetic effect between carbon, Fe3O4, and graphene. As an anode material of Li‐ion batteries (LIBs), C/Fe3O4@G manifests a high reversible capacity, excellent rate behavior, and outstanding long‐term cycling performance (1208 mAh g−1 after 200 cycles at 100 mA g−1).
Non‐Pincer‐Type Mononuclear Scandium Alkylidene Complexes: Synthesis, Bonding, and Reactivity
Authors: Wang Chen , Zhou Jiliang , Zhao Xuefei , Maron Laurent , Leng Xuebing , Chen Yaofeng 
Published: November 2015

AbstractThe first non‐pincer‐type mononuclear scandium alkylidene complexes were synthesized and structurally characterized. These complexes exhibited short Sc−C bond lengths and even one of the shortest reported to date (2.1134(18) Å). The multiple character of the Sc−C bond was highlighted by a DFT calculation. This was confirmed by experimental reactivity study where the complex underwent [2+1] cycloaddition with elemental selenium and [2+2] cycloaddition with imine. DFT calculation also revealed a strong nucleophilic behavior of the alkylidene complex that was experimentally demonstrated by the C−H bond activation of phenylacetylene.
Assessment of Short‐term Blood Pressure Variability in Patients With Ascending Aortic Dilatation
Authors: Karataş Mehmet Baran , İpek Göktürk , Çanga Yiğit , Güngör Barış , Özcan Kazim Serhan , Arugaslan Emre , Günaydin Zeki Yüksel , Durmuş Gündüz , Onuk Tolga , Kalenderoğlu Koray , Akdeniz Evliya , Bolca Osman 
Published: November 2015

ABSTRACTBackgroundBlood pressure variability (BPV) is a novel parameter related to adverse cardiovascular findings and events, especially in hypertensive patients. The aim of the present study was to investigate the relationship between short‐term BPV and ascending aortic dilatation (AAD).HypothesisHypertensive patients with AAD may exhibit higher short‐term BPV compared to hypertensive patients with normal diameter ascending aorta and BPV may be correlated with aortic sizes.MethodsSeventy‐six hypertensive patients with AAD and 181 hypertensive patients with a normal‐diameter ascending aorta were retrospectively enrolled in the study. Clinical data, echocardiographic characteristics, and 24‐hour ambulatory blood pressure monitoring characteristics were compared between the 2 groups. Standard deviation (SD) and Δ of BP were used as parameters of BPV.ResultsAlthough 24‐hour mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar between the 2 groups, the SD of SBP and SD of DBP values were significantly higher in AAD patients (17.2 ± 6.8 vs 13.8 ± 3.5, P < 0.01; and 12.1 ± 5.1 vs 10.7 ± 3.1, P = 0.02, respectively). Daytime SD of SBP values were higher in AAD patients, whereas nighttime SD of SBP values did not differ between groups. In multivariate linear regression analysis, 24‐hour SD of SBP, 24‐hour Δ SBP, daytime SD of SBP, daytime Δ SBP, and left ventricular mass index were independently correlated with aortic size index.ConclusionsOur study revealed higher levels of short‐term BPV in hypertensive patients with AAD. This conclusion warrants further study.
The Lysosomal Protein Saposin B Binds Chloroquine
Authors: Huta Brian P. , Mehlenbacher Matthew R. , Nie Yan , Lai Xuelei , Zubieta Chloe , Bou‐Abdallah Fadi , Doyle Robert P. 
Published: November 2015

AbstractChloroquine (CQ) has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. More recently, CQ is also becoming recognized as an important therapeutic compound for the treatment of autoimmune disorders and has shown activity as an anticancer agent. However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B (sapB), critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity. Using isothermal titration calorimetry (ITC) and fluorescence quenching experiments, CQ was shown to bind to the dimeric form of sapB at both pH 5.5 and pH 7.4 with an average binding affinity of 2.3×104 m−1. X‐ray crystallography confirmed this, and the first complete crystal structure of sapB with a bound small molecule (CQ) is reported. The results suggest that sapB might play a role in mitigating CQ‐based toxicity and that sapB might itself be overwhelmed by CQ causing impaired lipid degradation.