bluuebunny/crossref_metadata_2025_split huggingface dataset:
Por que (não) ler a obra horaciana como fonte de informações autobiográficas?
Authors: Piccolo Alexandre 
Published: June 2017

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Quando o poeta latino Horácio diz “eu” em seus textos (epodos, odes, sátiras, epístolas), podemos ver, nas diferentes instâncias desse pronome pessoal, expressões que revelam alguma faceta de um eu empírico? - eis a pergunta que nos guia nesse </span><span>artigo. Não raro velado por </span><em>tópoi </em><span>da tradição e por alusões a outros poetas gregos, o discurso lírico costuma dificultar a construção de uma imagem pessoal do poeta. Por outro lado, a natureza peculiar do texto epistolar pode nos auxiliar a refinar os traços da </span><em>persona </em><span>poética rumo a uma aparência real do poeta. A fronteira entre o </span><span>que é textual e o que pode ser pessoal é uma das dificuldades dessa tarefa. </span></p></div></div></div>
famaque cum domino fugit ab urbe suo: aspectos da fama na poesia de exílio de Ovídio
Authors: Michalopoulos Andreas N. 
Published: June 2017

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p>Através de sua poesia pré-exílio, Ovídio revela grande interesse em <em>Fama/fama</em> em todos os seus significados e funções: reputação pessoal, fama literária, tradição literária e mitológica, rumor, boato. Ovídio é obcecado por sua própria reputação como poeta, enquanto também emprega <em>Fama/fama</em> como fonte de inspiração e como fonte de informação numa ampla variedade de temas e tópicos. Seu grande interesse em <em>Fama/fama</em> culmina em sua famosa descrição de seu domicílio no livro XII das <em>Metamorfoses</em>. O objetivo deste artigo é discutir o uso e o papel de <em>Fama/fama</em> na poesia do exílio de Ovídio, escrita num momento em que as circunstâncias da vida do poeta mudaram dramaticamente. O poeta se encontra em arredores bárbaros e incivilizados, longe da linda e confortável vida da capital. A discussão dos poemas selecionados dos <em>Tristia</em> e das <em>Epistulae ex Ponto</em> ilustrarão de forma promissória a relação de Ovídio com a Fama/fama.</p><div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><strong>Abstract</strong></p><p><span>Throughout his pre-exilic poetry Ovid shows a keen interest in Fama/fama in all its meanings and functions: personal reputation, literary fame, literary and mythological tradition, rumour, hearsay. Ovid is obsessed with his own reputation as a poet, while he also employs Fama/fama as a source of inspiration and as a source of information on a wide variety of themes and topics. His great interest in Fama/fama culminates in his famous description of her abode in the 12th book of the Metamorphoses. The object of this paper is to discuss the use and the role of Fama/fama in Ovid’s exilic poetry, written at a time when the circumstances of the poet’s life changed dramatically. The poet finds himself in barbaric and uncivilized surroundings, away from the beautiful and comfortable life of the capital. The discussion of selected poems from the Tristia and the Epistulae ex Ponto will hopefully illustrate Ovid’s relationship with Fama/fama. </span></p><p><strong>Keywords</strong><span><strong>:</strong> Ovid; </span><span>Fama</span><span>; exile poetry </span></p></div></div></div></div></div></div>
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides
Authors: Majellaro Maria , Stefanachi Angela , Tardia Piero , Vicenti Chiara , Boccarelli Angelina , Pannunzio Alessandra , Campanella Federica , Coluccia Mauro , Denora Nunzio , Leonetti Francesco , de Candia Modesto , Altomare Cosimo Damiano , Cellamare Saverio 
Published: June 2017

AbstractA number of trimethoxybenzoic acid anilides, previously studied as permeability glycoprotein (P‐gp) modulators, were screened with the aim of identifying new anticancer agents. One of these compounds, which showed antiproliferative activity against resistant MCF‐7 cell line, was selected as the hit structure. Replacement of the trimethoxybenzoyl moiety with a nicotinoyl group, in order to overcome solubility issues, led to a new series ofN‐biphenyl nicotinoyl anilides, among which a nitro derivative,N‐(3′,5′‐difluoro‐3‐nitro‐[1,1′‐biphenyl]‐4‐yl)nicotinamide (3), displayed antiproliferative activity against MCF‐7 and MDA‐MB‐231 cells in the nanomolar range. The search for a bioisostere of the nitro group led to nitrile analogueN‐(3‐cyano‐4′‐fluoro‐[1,1′‐biphenyl]‐4‐yl)nicotinamide (36), which shows a strong increase in activity against MCF‐7 and MDA‐MB‐231 cells. Compound36induced a dose‐dependent accumulation of G2‐ and M‐phase MCF‐7 cell populations, and a decrease in S‐phase cells. Relative to vinblastine, a well‐known potent antimitotic agent, compound36also induced G1‐phase arrest at low doses (20–40 nm), but did not inhibit in vitro tubulin polymerization.
Is Low FMR1 CGG Repeat Length in Males Correlated with Family History of BRCA‐Associated Cancers? An Exploratory Analysis of Medical Records
Authors: Adamsheck Hallee C. , Petty Elizabeth M. , Hong Jinkuk , Baker Mei W. , Brilliant Murray H. , Mailick Marsha R. 
Published: June 2017

AbstractThe FMR1 gene has been studied extensively with regard to expansions and premutations, but much less research has focused on potential effects of low CGG repeat length. Previous studies have demonstrated that BRCA1/2 positive women are more likely to have an FMR1 genotype with one low CGG allele, and that women with both FMR1 alleles in the low CGG repeat range are more likely to have had breast cancer compared to women with normal numbers of CGG repeats. However, there has been no research as to whether low CGG repeat length impacts cancer risks in men. Therefore, this study aimed to examine cancer incidence and related risk factors in men with low CGG repeat length in the FMR1 gene. We utilized subject data from the Marshfield Personalized Medicine Research Project to compare cancer‐related diagnoses between 878 males with low CGG repeat length (< 24 repeats) and 368 male controls with CGG repeats in the normal range (24 to 40 repeats). We utilized ICD‐9 codes to examine various cancer diagnoses, family histories of cancer, other non‐malignant neoplasms, cancer surveillance, and genetic susceptibility. Men with low CGG repeats were identified to have significantly higher rates of family history of any cancer type (p = 0.011), family history of any BRCA‐associated cancer (p = 0.002), and specifically, family history of prostate cancer (p = 0.007). The mean number of BRCA‐associated cancer diagnoses (breast, prostate, pancreatic, and melanoma) per individual in the low CGG group was slightly higher than that of the control group, with this difference trending toward significance (p = 0.091). Additionally, men with low CGG repeats had significantly higher rates of connective/soft tissue neoplasms (p = 0.026). Additional research is needed to replicate the observations reported in this preliminary exploratory study, particularly including verification of ICD‐9 codes and family history by a genetic counselor.
Family Communication, Risk Perception and Cancer Knowledge of Young Adults from BRCA1/2 Families: a Systematic Review
Authors: Young Alison L. , Butow Phyllis N. , Vetsch Janine , Quinn Veronica F. , Patenaude Andrea F. , Tucker Katherine M. , Wakefield Claire E. 
Published: June 2017

AbstractUnderstanding challenges in familial communication of cancer risk has informed genetic service delivery. Parent‐child interactions have received considerable attention, but few studies focus on young adulthood experiences within BRCA1/2 families. Young adults are approaching, or at a life stage where awareness of hereditary cancer risk is vital for informed choice of risk management options. This review assesses family communication, risk perception and cancer knowledge held by 18–40 year old individuals who have a parent with a BRCA1/2 gene mutation or carry the gene mutation themselves. Thirteen papers met the inclusion criteria. One utilized a ‘mixed methods’ methodology and the remaining used a qualitative approach. Findings were synthesized into themes and reported narratively. In general, parents are communicating openly about genetic risk with young adult offspring, but there is evidence that some young adults are withholding information from their parents about their own test results. Risk perception is influenced by a family history of cancer, childbearing plans and health providers’ advice. Misconceptions about genetic risk appear to be common and gaps in hereditary cancer knowledge are evident. It is unclear whether incorrect knowledge was passed from parents to offspring. Health providers need to provide developmentally appropriate services for emerging adults (18–25 years old), with particular support in navigating through risk management options.
Problems of Screening for Psychiatric Comorbidity in the Medically Ill: What Can be Recommended?
Authors: Diefenbacher A. 
Published: June 2017

CL-psychiatrists have to work under severe time pressure in acute care setting. Hence, it is necessary to have an armamentarium of screening tools for disorders most frequently met in the general hospital. This presentation will discuss such tools for delirium, alcohol abuse, depression, personality disorders (“how to manage difficult patients”), attachment styles. On a conceptual level, the so-called “situational approach” in cl-psychiatry will be discussed.Disclosure of interestThe author has not supplied his declaration of competing interest.
Interdisciplinary Treatment and Complex Rehabilitation of Internally Displaced Persons in University Clinic
Authors: Korostiy V. , Platynuk O. 
Published: June 2017

IntroductionOver 1,5 million of them are Ukrainians who were forced to leave their home after Crimea annexation and military conflict in the East of Ukraine.ObjectivesBy 2015, the University Clinic asked 156 people displaced from Lugansk and Donetsk regions. Reasons treatment: all patients were somatic complaints. In screening: using the scale hospital, all patients were found higher rates of anxiety and depression. Overall, 48% of patients abandoned psychiatric examination, even 24% of psychological counseling.AimsScreening of IDPs’ mental health who sought medical help in somatic clinic (University clinic KhNMU) and estimation of efficiency of interdisciplinary treatment and complex rehabilitation.MethodsPsychodiagnostical, clinical-psychological, clinical-psychopathological.ResultsClinical examination during the period of acute stress reactions was observed, dominated by anxiety disorders, prolonged depressive reaction. Anxiety disorders were found in 56.5%, prolonged depressive reaction in 32.0%, post-traumatic stress disorder in 10.5% of patients. The treatment of the underlying disease, complex psychological and physical rehabilitation. Psychological rehabilitation included CBT, relaxation, art therapy. Physical rehabilitation includes kinesiotherapy and TRE. A set of measures of physical rehabilitation led to reduction of anxiety to physiological levels in all mentally healthy patients, reduce the severity of psychosomatic symptoms in the structure of the underlying disease, increased satisfaction with the results of treatment by 28.5%.ConclusionsAnalysis of mental health study of IDPs and evaluation of comprehensive rehabilitation in terms of the University Clinic show the need for screening mental state when applying for medical assistance and the desirability of psychological and physical rehabilitation of patients during hospital stay somatic profile.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Native vs. Migrants – same Opportunities or Discriminated? – Psychiatry Trainees's Views from the EFPT Brain Drain Study
Authors: Costa M. Pinto da , Tomori S. , Mogren T. , Biskup E. , Baessler F. , Frydecka D. , Killic O. , Group E. Research 
Published: June 2017

IntroductionIt is a well known fact that qualified health professionals generally migrate to high-income, developed regions. Nevertheless, the perceptions of this immigrant skilled health workforce on access to opportunities or feeling discriminated in their host countries, have not yet been explored or adequately addressed.ObjectivesThis work has focused on the perceptions of immigrant psychiatry trainees in several European countries about their views on having equal access to opportunities as natives or feeling discriminated.MethodsA semi-structured 61-item questionnaire was circulated by National Coordinators in each country and was completed by 2281 psychiatric trainees from 33 European countries between year 2013 and 2014. Data has been analysed using the Software Package for Social Sciences for Windows v. 22.0 (SPSS Inc. Chicago, IL).ResultsIn these findings, more than one in ten psychiatry trainees across Europe were immigrants, with top host countries being Switzerland, Sweden and UK. Satisfaction with migration and the perception of having equal opportunities as the native trainees varied depending on the host country they migrated to. More than one-third of the trainees felt discriminated, not having the same opportunities as the local colleagues, especially concerning the work opportunities and the academic conditions. Still, nearly two-thirds considered having the same opportunities than natives.ConclusionsA high number of immigrant psychiatry trainees subjectively feels they do not have the same opportunities as local trainees. Further research about factual and perceived discrimination by immigrant workforce should be done.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Atypical Callosal Morphology in Developmental Language Disorder
Authors: Luders E. , Kurth F. , Pigdon L. , Conti-Ramsden G. , Reilly S. , Morgan A. 
Published: June 2017

IntroductionDevelopmental language disorder (DLD) is common, yet the neurobiology of DLD is poorly understood. A key hypothesis suggests atypical functional lateralization of language, which might be accompanied structurally by a deficit in inter-hemispheric connectivity of language-related regions. Indeed, aberrations of the corpus callosum have been associated with language deficits in children with frank neurological lesions and/or born pre-term. In contrast, studies examining the corpus callosum in children with DLD remain elusive.ObjectiveWe aimed to expand this largely understudied field by comparing callosal morphology between 17 children with DLD and 17 typically developing children carefully matched for sex and age.MethodsWe analyzed high-resolution structural magnetic resonance imaging data applying a well-validated computational approach, which captures the thickness of the corpus callosum with a high regional specificity at 100 equidistant points.ResultsAs shown in Fig. 1, we observed a significantly thinner corpus callosum, particularly in the splenium, in children with DLD compared to typically developing controls (DLD < CTL).ConclusionsThese findings indicating pronounced aberrations in the brain's largest whiter matter tract make an important contribution to an understudied field of research and support the theory that DLD is accompanied by atypical lateralization of language function.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Case Report Klinefelter Syndrome and Multiple Sclerosis as the Cause of Psychosis
Authors: Rodriguez Rodriguez A. , Blanco Fernández R. , Vizcaino da Silva M. , Fernández Fernández R. , Mendez Gonzalez O. 
Published: June 2017

Introduction and goalsForty-three-year-old male diagnosed with Klinefelter syndrome and showing radiological findings suggesting a demyelinating pathology who presents several psychiatric manifestations including megalomaniacal ideation, delusion, lack of impulse control and behavioral alterations.Clinical caseForty-three-year-old male diagnosed with Klinefelter syndrome at the age of 31, presenting several psychiatric pathologies since adolescence: delusions, megalomania, mood fluctuation, and high impulsiveness. The patient had a poor therapeutic response to anti-psychotic drugs and ECT. He was hospitalized up to 9 times, but the full control of the symptomatology was not achieved. During his last hospitalization, a MRI revealed lesions compatible with a demyelinating pathology.DiscussionA higher prevalence of schizophrenia spectrum disorders has been described among patients suffering from Klinefelter syndrome, which might explain the role of the X chromosome in the susceptibility to psychiatric disorders, particularly to psychosis. Furthermore, the brain structure alterations presented by patients suffering from Klinefelter syndrome are similar to those described among schizophrenic patients: small brain volume, lateral cerebral ventricular enlargement and reduced temporal gyrus, amygdala, insula and cingulate cortex. Patients suffering from multiple sclerosis are more prone to psychiatric disorders, such as mood swing, aggressiveness or psychosis, which are not concurrent with the physical progression of the disease, sometimes being its first manifestation. Even when being patchy and multifocal, demyelination seems to be concentrated in the frontal lobes, related to the cognitive and affective functions and the personality.ConclusionsBoth multiple sclerosis and Klinefelder syndrome may alter the brain structure, mainly in the frontal lobe, and predispose to psychiatric disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.
In Search of Possible Peripheral Biomarkers for Suicide: Similarities Between Platelet and Cerebrospinal Fluid Proteome (Preliminary Results)
Authors: Semančíková E. , Tkáčiková S. , Talian I. , Bencková M. , Pálová E. , Sabo J. 
Published: June 2017

Despite the fact that proteomic analysis is becoming widely used in various medical branches its use in psychiatry is still very limited. Majority of psychiatric proteomic research is still oriented mostly on Alzheimer's disease, schizophrenia and depression but very few studies focus on suicidality. We decided, based on the current knowledge, to study suicidal behaviour with the use of proteomics to compare cerebrospinal fluid and platelets. We hypothesized that the same protein group can be detected in pathways that are part of platelet degranulation process in the platelet proteome and cerebrospinal fluid proteome. Based on these findings we suppose, that with use of proteomic analysis a specific protein (group of proteins) can be identified in both, cerebrospinal fluid and platelet proteome in patients with suicidal behavior.Group of proteins identified in our sample in the reactome pathway database (release of platelet secretary granule components and exocytosis of platelet granule contents) supports the idea of link between central nervous system and platelets (“the periphery”). Further research is needed to clarify whether the identified group of proteins taking part in platelet pathways can be used as peripheral biomarkers for suicidal behavior.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Effects of Hazardous Alcohol use on Neurocognition in HIV Positive Individuals
Authors: Spies G. , Hoddinott G. , Beyers N. , Seedat S. 
Published: June 2017

IntroductionThere is significant evidence that HIV is brain degenerative and long-term infection can impair cognitive functioning. In South Africa, alcohol remains the dominant substance of abuse and lifetime alcohol dependence has been found to impair memory, executive function and visuospatial capabilities. The individual liability of alcohol and HIV on neurocognitive function have been well demonstrated, however there is relatively little evidence of the potentially aggravating effects of this dual burden on neurocognitive outcomes.ObjectivesThe present study is ongoing and sought to identify the effects of hazardous alcohol use on neurocognitive functioning in the context of HIV infection.AimsTo describe the association between HIV and harmful alcohol use on neuropsychological test performance in a cohort of adults in the Western Cape of South africa.Methodsparticipants (n = 50) were tested using a battery of neuropsychological tests sensitive to the effects of HIV on the brain. Self-reported alcohol use was recorded using the alcohol use identification test (AUDIT). Results The sample consisted of 47 females and 3 males. All participants were HIV-positive and on antiretroviral therapy. A total of 23 (46%) participants reported no alcohol use and 27 (54%) reported drinking alcohol on the AUDIT.Resultsrevealed a significant difference between groups on the Stroop colour word test, with poorer performance evident among the alcohol users (P = 0.008).ConclusionAlcohol use in the context of HIV infection contributes to poorer executive function. These preliminary data provide evidence for a synergistic relationship between HIV infection and alcohol use.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A Case of Erotomanic Delusion in Dementia
Authors: Arts M. , Petrykiv S. , Fennema J. , De Jonge L. 
Published: June 2017

IntroductionIn dementia, delusions are common with prevalence up to 75%. However, erotomanic delusions, or De Clerambault's syndrome, are a rarity in dementia. To date, only six case-reports have been described in vascular dementia, frontotemporal dementia, and Alzheimer's dementia.ObjectivesTo present a case of De Clerambault's syndrome in an older adult diagnosed with vascular dementia.AimsTo review available literature on De Clerambault's syndrome in dementia.MethodsA case report is presented and discussed followed by a literature review.ResultsWe report a 72-year-old female with a history of right posterior cerebral artery infarction. The patient developed a sudden onset erotomanic delusion after she met a male patient of her age during her stay in a dementia day care center. She was agitated, disorientated, presented with confabulation, and showed a dysphoric mood. On MMSE she scored 14/30, the clock-drawing test revealed visuospatial deficits. On MRI, the right occipital lobe showed an encephalomalacia. The patient was treated with sertraline 50 mg/day and olanzapine 5 mg/day. Her erotomanic delusions improved after 3 months of treatment.ConclusionDe Clerambault's syndrome is a rare and poorly understood disorder with generally a poor response to treatment. Some cases were successfully treated with atypical anti-psychotics. However, further research is needed to explore the course and treatment of this delusion.Disclosure of interestThe authors have not supplied their declaration of competing interest.