bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon-Aware Memory Placement
Authors: Köhler Sven , Herzog Benedict , Herzog Henriette , Vögele Manuel , Wenzel Lukas , Polze Andreas , Hönig Timo 
Published: September 2024

The carbon footprint of software activities is determined by embodied and operational emissions of hardware resources. This paper presents cMemento, a concept that enables operating systems to make carbon-aware memory placement decisions.
Main memory has become heterogeneous in today's computer systems. In addition to traditional (and volatile) main memory (e.g. DRAM), novel memory technologies with persistent properties are often also available (e.g. PRAM, FRAM, MRAM). Complementary, there are a large number of new memory interfaces (e.g. high-bandwidth, graphics, and low-power memory) that have to be additionally taken into account by the operating system when allocating memory. The availability of new memory technologies and interfaces enables systems with improved energy efficiency. At the same time, the new memory interfaces have revealed serious flaws in the current state-of-the-art memory abstractions in operating systems. Hence, moving away from the homogeneous perspective of memory resources is a crucial step towards significantly reducing the energy consumption and, ultimately, the carbon footprint of today's computer systems.
With cMemento, we propose an approach that combines information on characteristics of (i) active workloads and (ii) available memory resources with a carbon model. cMemento transforms the combined information into memory placement decisions at operating system level. The placement decisions that are made result in improved operating conditions (i.e. better energy efficiency and lower carbon footprint) for the available memory resources.
Widening the Operational Temperature Range of Lithium Batteries Using Flame-Retardant Sulfone-Based Highly Concentrated Electrolytes
Authors: Ugata Yosuke , Wada Gakuto , Miyazaki Shuhei , Dokko Kaoru 
Published: September 2024

High-concentration Li salt/sulfone solutions have attracted attention as promising liquid electrolytes for Li batteries owing to their high oxidative stability, nonflammability, and high Li+ ion transference number (t
Li+). Herein, we report the temperature-dependent electrolyte properties of a sulfone-based ternary mixture composed of LiN(SO2F)2, sulfolane, and dimethyl sulfone, which enables Li batteries to operate in a wide temperature range. At −20 °C, the rate capability of a Li/LiCoO2 cell with the sulfone-based electrolyte was comparable to that with a conventional carbonate-based electrolyte, even though the ionic conductivity of the electrolyte was significantly lower in the former case (0.11 versus 2.92 mS cm−1). This is because the former electrolyte has a higher t
Li+ value, effectively suppressing the concentration overpotential during cell charging and discharging. Moreover, the vapor pressure was much lower for the sulfone-based electrolyte than for the carbonate-based one, and the Li/LiCoO2 cell with the former electrolyte was successfully operated at 60 °C. This study provides insights into the characteristics of high-concentration electrolytes that affect the temperature dependence of Li battery performance.
Body Composition Changes Impact Islet β‐Cell Function in Patients With Type 2 Diabetes Mellitus
Authors: Lin Yuxi , Zhang Yongze , Shen Ximei , Weng Zhiyan , Huang Lingning , Zhao Fengying , Yan Sunjie 
Published: September 2024

Background: Identifying β‐cells dysregulation in type 2 diabetes mellitus (T2DM) is crucial. Weight fluctuations are frequently observed during diabetes treatment. However, the relationship between body composition changes and islet β‐cell function in individuals with T2DM remains insufficiently investigated.Methods: This retrospective longitudinal study encompassed a cohort of 775 T2DM patients, who underwent body composition measuring using dual‐energy X‐ray absorptiometry (DEXA) and followed up for a median of 2.29 years. Key metrics included body mass index (BMI), fat mass index (FMI), trunk fat mass index (TFMI), muscle mass index (MMI), appendicular skeletal muscle mass index (ASMI), muscle/fat mass ratio (M/F), and the appendicular skeletal muscle mass/trunk fat mass ratio (A/T) were then categorized and grouped. Insulin, C‐peptide, and glucose levels were assessed concurrently following a glucose load. β‐cell function included insulin resistance (HOMA‐IR), insulin sensitivity (Matsuda index (MI)), and insulin secretion evaluated by HOMA‐β and C‐peptidogenic index (CGI).Results: Although no significant changes in BMI were observed, patients with T2DM at readmission exhibited higher FMI, TFMI, and ASMI, as well as elevated levels of HOMA‐IR, MI, and CGI compared to baseline measurements. And lower MI, higher levels of CGI, and HOMA‐IR were observed in BMI increased group. Univariate correlation analysis revealed a negative association between changes in BMI (ΔBMI) and ΔMI, while positive associations were observed in both ΔHOMA‐IR and ΔCGI. Among body composition indexes, ΔFMI exhibited the strongest correlation with ΔHOMA‐IR (r = 0.255, p < 0.001), and ΔASMI was positively associated with ΔMI and ΔCGI (r = 0.131 and 0.194, respectively). Moreover, increased levels of BMI and FMI were associated with a greater risk of progressive insulin resistance compared to the decreased, whereas the trend was converse in ASMI and A/T.Conclusions: Increased FMI may partially contribute to the deterioration of insulin resistance, while increased ASMI is associated with improved insulin sensitivity and secretion. Maintaining an appropriate BMI and muscle/fat ratio is conductive to prevent the progression of insulin resistance in patients with T2DM.
History of Infertility and Risk of Endometrial Cancer in the Women’s Health Initiative
Authors: Harris Holly R. , Saboda Kathylynn , Thomson Cynthia A. , Saquib Nazmus , Shadyab Aladdin H. , Schnatz Peter F. , Robles-Morales Rogelio , Qi Lihong , Roe Denise J. , Farland Leslie V. 
Published: September 2024

Abstract

Background:
Several studies have suggested an association between infertility and risk of endometrial cancer. However, most studies have evaluated this relationship in premenopausal people, yet the mean age of endometrial cancer is 60 years, after the average age of menopause.

Methods:
Our study included Women’s Health Initiative participants who self-reported whether they had a history of infertility. Cox proportional hazards models were used to examine the association between infertility and incident endometrial cancer. Given that all infertility diagnoses occurred prior to study enrollment, we conducted secondary analyses using logistic regression examining prevalent endometrial cancer cases diagnosed before study baseline.

Results:
Approximately 18% of participants reported a history of infertility. No statistically significant association was observed between infertility and risk of incident endometrial cancer overall [incident cases = 1,622; HR = 1.12; 95% confidence interval (CI) = 0.99–1.26]. Although point estimates suggested an increase in risk of endometrial cancer among women with body mass index (BMI) ≥25 (HR = 1.15; 95% CI = 0.99–1.33), none of the associations were statistically significant. There was an association between history of infertility and prevalent endometrial cancer cases (OR = 1.19; 95% CI = 1.06–1.34), with the strongest association for infertility diagnosis due to endometriosis (OR 2.42; 95% CI = 1.83–3.19).

Conclusions:
In a population of postmenopausal participants, we observed a modest, but not statistically significant, association between overall infertility and incident endometrial cancer, with the suggestion of a higher risk among those with a BMI ≥ 25.

Impact:
Our findings highlight, as observed in previous studies, that risk factors for endometrial cancer may vary by BMI.
Patients With Nonobstructive Coronary Artery Disease and Chest Pain: Impact of Obesity and Depressive Symptoms
Authors: Vatsa Nishant , Dave Esha , Higgins Melinda , Huang Jingwen , Desai Shivang R. , Gold Daniel A. , Gold Matthew E. , Jain Vardhmaan , Fatade Yetunde K. , Rahbar Alireza , Kimble Laura P. , Ko Yi‐An , Sperling Laurence S. , Quyyumi Arshed A. , Mehta Puja K. 
Published: September 2024

Background
Chest pain (CP) in patients with nonobstructive coronary artery disease is a therapeutic challenge affecting morbidity and mortality. We aimed to identify clinical factors associated with CP in this population, hypothesizing that obesity and depressive symptoms are associated with CP.

Methods and Results

In 814 patients with angiographically confirmed nonobstructive coronary artery disease, we measured sociodemographic variables, clinical risk factors, medications, and Patient Health Questionnaire 9 scores for depressive symptoms. We assessed CP frequency and prevalence by using all items from the Seattle Angina Questionnaire angina frequency domain to generate an angina frequency composite score. In the overall sample (58.8±11.7 years old, 52.6% female), 42.8% had obesity, and 71.5% had CP, with an angina frequency composite score (SD) score of 76.4 (22.1). Compared with individuals without obesity, individuals with obesity had a higher prevalence (77.6% versus 67%,
P
<0.001) and more frequent CP (angina frequency composite score, 74.9 [SD, 22.2] versus 78.3 [SD, 21.9],
P
=0.02). Obesity was independently associated with CP occurrence (odds ratio [OR], 1.7 [95% CI, 1–2.9],
P
=0.04). Obesity's connection with CP was only in men: men with obesity had more frequent CP (angina frequency composite score, 75.8 [SD, 20.1] versus 82.1 [SD, 19.9],
P
=0.002) and more prevalent CP (79.5% versus 58.2%,
P
<0.001) than their counterparts insofar as men with obesity had similar CP to women. Patient Health Questionnaire 9 score (OR, 1.07 [95% CI, 1.01–1.13],
P
=0.03) was independently associated with CP and partly mediated the association between obesity and CP.

Conclusions
Obesity and depressive symptoms were independently associated with CP in individuals with nonobstructive coronary artery disease, particularly in men, and depressive symptoms partly mediated this association.
Left Ventricular Outflow Tract Morphology as a Predictor of Conductance Disturbances Following Transcatheter Aortic Valve Replacement
Authors: Espejo‐Paeres Carolina , Marroquín‐Donday Luis Alfonso , Hennessey Breda , Wang Lin , McInerney Angela , Paredes‐Vázquez José G. , Pérez‐Vizcayno María , Tirado‐Conte Gabriela , Macaya‐Ten Fernando , Mejía‐Rentería Hernán , Salinas Pablo , Núñez‐Gil Iván Javier , Gonzalo Nieves , Nombela‐Franco Luis , Escaned Javier , Fernández‐Ortiz Antonio , Pérez‐Villacastín Julián , Jiménez‐Quevedo Pilar 
Published: September 2024

Background
Conduction disturbances represent one of the most common complications following transcatheter aortic valve replacement (TAVR). We sought to investigate the role of left ventricular outflow tract (LVOT) morphology in the development of conduction disturbances following TAVR.

Methods and Results

Consecutive patients who underwent TAVR in our center were included. The ratio between the LVOT area and the aortic annulus area was calculated. Patients were then divided into 2 groups on the basis of this ratio: group 1, which included patients with an LVOT area/aortic annulus area ratio <0.9; and group 2, which included patients with an LVOT area/aortic annulus area ratio ≥0.9. The primary end point was to assess the relationship between LVOT shape and the rate of permanent pacemaker implantation following TAVR. A multivariable analysis was performed to identify predictors of permanent pacemaker implantation following TAVR. From January 2018 to December 2020, 276 patients were included. Ninety‐one patients with tapered LVOT morphology were assigned to group 1 and the rest (n=185 patients), tubular LVOT or flared LVOT shape, to group 2. The mean age was 81.5±5.7 years and 57% were women. After adjusting by confounding factors, tapered morphology of the LVOT and prior right bundle‐branch block were found to be independent predictors of permanent pacemaker implantation (hazard ratio [HR], 2.6 [95% CI, 1.2–5.7];
P
=0.014; and HR: 4.3 [95% CI 2.4–7.6],
P
<0.001); at a median follow‐up time of 15.5 (interquartile range, 15) months.

Conclusions
A tapered‐LVOT morphology was associated with increased risk for permanent pacemaker implantation. LVOT morphology may be an additional factor to consider when choosing prosthesis size.
Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes
Authors: Tan Eugene S. J. , Choi Hyungwon , DeFilippi Christopher R. , Oon Yen‐Yee , Chan Siew‐Pang , Gong Lingli , Lunaria Josephine B. , Liew Oi‐Wah , Chong Jenny Pek‐Ching , Tay Edgar Lik‐Wui , Soo Wern‐Miin , Yip James Wei‐Luen , Yong Quek Wei , Lee Evelyn Min , Daniel Yeo Poh Shuan , Ding Zee Pin , Tang Hak Chiaw , Ewe See Hooi , Chin Calvin W. L. , Chai Siang Chew , Goh Ping Ping , Ling Lee Fong , Ong Hean Yee , Richards A. Mark , Ling Lieng‐Hsi 
Published: September 2024

Background
Echocardiographic indexes of aortic stenosis may not comprehensively reflect disease morbidity. Plasma proteomic profiling may add prognostic value in these patients.

Methods and Results

Proximity extension assays (Olink) of 183 circulating cardiovascular and inflammatory proteins were performed in a prospective follow‐up study of 122 asymptomatic/minimally symptomatic patients (mean±SD age, 69.1±10.9 years; 61% men) with moderate to severe aortic stenosis and preserved left ventricular ejection fraction. Protein signatures of higher‐risk echocardiographic subgroups were determined. Associations of proteins with the primary composite outcome (heart failure hospitalization, progression to New York Heart Association class III‐IV, or all‐cause mortality) were evaluated using competing risk analyses, with aortic valve replacement being the competing risk. Network analysis unveiled mutually exclusive communities of proteins and echocardiographic parameters, connected only through NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide). Members of the tumor necrosis factor receptor superfamily (TNFRSF1A, TNFRSF1B, and TNFRSF14), and trefoil factor‐3 were major hub proteins among the circulating biomarkers. Left ventricular global longitudinal strain >−15% was associated with higher levels of proteins, primarily of inflammation and immune regulation, whereas aortic valve area <1 cm
2
, E/e’ >15, and left atrial reservoir strain <20% were associated with higher levels of NT‐proBNP. Of 14 proteins associated with the primary end point, phospholipase‐C, C‐X‐C motif chemokine‐9, and interleukin‐10 receptor subunit β demonstrated the highest hazard ratios after adjusting for clinical factors (
q
<0.05).

Conclusions
Plasma proteins involved in inflammation and immune regulation were differentially expressed in patients with aortic stenosis with reduced left ventricular global longitudinal strain, and associated with adverse clinical outcomes. Their incorporation into aortic stenosis risk stratification warrants further assessment.
Revealing the Novel Role of Purinergic Receptor P2X4 in Phagocytic Uptake After Ischemic Stroke
Authors: Gamiotea‐Turro Daylin , Cronin Chunxia G. , Yadav Sanjeev Kumar , Yadawa Arun Kumar , Cormier Mary‐Katherine , Liang Bruce T. , Verma Rajkumar 
Published: September 2024

Background
Purinergic receptor P2X4 (P2X4R), highly expressed on microglia and macrophages, is activated by ATP released from damaged cells and linked to poststroke inflammation. Previous studies showed that short‐term P2X4R inhibition reduces inflammation and promotes long term recovery, but the mechanism underlying P2X4R and inflammation remains unclear. We hypothesized that P2X4R absence or pharmacological blockade can enhance macrophage phagocytic function by alleviating excessive inflammation after stroke.

Methods and Results
We divided P2X4R knockout and littermate control mice into 2 groups either naive or mice subjected to ischemic stroke surgery. Additionally, the regular WT mice subjected to ischemic stroke were treated with 5‐(3‐Bromophenyl)‐1,3‐dihydro‐2H‐Benzofuro[3,2‐e]‐1,4‐diazepin‐2‐one BD (a P2X4R inhibitor) or vehicle. We isolated phagocytic cells from mice in each group and assayed phagocytic activity by quantifying uptake of fluorescent beads and bioparticles using flow cytometry or confocal microscopy and by measuring protein expression related to phagocytosis. Short‐term inhibition of P2X4R with with 5‐(3‐Bromophenyl)‐1,3‐dihydro‐2H‐Benzofuro[3,2‐e]‐1,4‐diazepin‐2‐one treatment upregulated ANXA1 (annexinA1). P2X4R absence prevented ATP‐induced decline in phagocytic uptake in macrophages. Microglia or macrophages derived from P2X4R knockout mice showed significantly increased phagocytic activity compared with microglia/macrophages taken from littermate control mice. Cell surface expression of CD36, a scavenger receptor protein, increased after stroke, and was higher in P2X4R knockout mice.

Conclusions
This study suggests that blockade or absence of P2X4R increases phagocytic uptake of damaged tissue following ischemic stroke. Taken together with previous reports detailing how P2X4R inhibition is protective following stroke, our results demonstrate P2X4R may mediate long‐term resolution after ischemic stroke by enhancing phagocytic clearance.
NOAAGlobalTemp Version 6: An AI-Based Global Surface Temperature Dataset
Authors: Yin Xungang , Huang Boyin , Menne Matthew , Vose Russell , Zhang Huai-Min , Adeyeye Adedoja , Applequist Scott , Gleason Karin , Liu Chunying , Sanchez-Lugo Ahira 
Published: September 2024

Abstract
The National Oceanic and Atmospheric Administration Global Surface Temperature (NOAAGlobalTemp) dataset is widely used for scientific research, operational monitoring, and climate assessment activities. Aligning with NOAA’s mission values, NOAAGlobalTemp has been updated to version 6 (i.e., NGTv6), which includes two enhancements over its predecessor (NGTv5). The first enhancement is the expansion of the spatial coverage to encompass the entire globe and the extension of temporal coverage back to 1850 (an interim version of NOAAGlobalTemp with these features was released in February 2023). The expansion of spatial coverage is accomplished by utilizing surface air temperatures over the Arctic Ocean and by eliminating the data reconstruction mask used in NGTv5 that had suppressed interpolation in data-sparse regions. This change has important implications for global temperature trends since the Arctic region has been warming at a much faster pace, more than 4 times the global average, in the twenty-first century to date. The second enhancement is the implementation of a methodology based on artificial intelligence (AI) for reconstructing surface air temperature over the global land surface and the Arctic Ocean. The AI model employs an artificial neural network to fill data gaps and is demonstrated to be more robust, stable, and accurate than the previous gap-filling method, particularly in observation-sparse areas such as the polar regions. The model outperforms the previous approach across all evaluated statistical metrics, and the output reaches a stable state more quickly as observations are received, which facilitates climate monitoring. NGTv6 was released in February 2024.
Investigation on the structure and thermal properties of HDPE/Ta2O5-based nanocomposites
Authors: Huseynova A.S. , Rzayev R.M. , Hajiyeva F.V. 
Published: September 2024

This work reports on the influence of tantalum oxide nanoparticles on the structure and thermal properties of HDPE + Ta2O5 based polymer nanocomposites prepared by ex-situ solution casting method. XRD analysis confirmed the orthorhombic structure of Ta2O5 nanoparticles and an increase in the degree of crystallinity of HDPE/Ta2O5 based nanocomposites after the introduction of Ta2O5 into the HDPE matrix. SEM analysis showed that Ta2O5 nanoparticles were distributed over the surface of the sample in a spherical shape. FT-IR analysis confirmed the presence of Ta –O-Ta stretching vibration bands at 557 cm−1, 584 cm−1, 599 cm−1, 614 cm−1 and Ta-O bands at 824 cm−1, 828 cm−1 for HDPE/3-7 wt%Ta2O5 nanocomposites. The results indicate that small amounts of Ta2O5 nanoparticles (3–7 wt.%) introduced into HDPE act as nucleating agents, which enhance the thermal properties of the HDPE/Ta2O5 nanocomposite. Additionally, the properties of the polymer nanocomposite are influenced by both the structural changes in the polymer matrix and the interactions at the nanoparticle-polymer interface.
Daily sibling interactions among latino children in middle childhood: An examination of familism values and sibling roles
Authors: Son Daye , Duran Julissa G. , Updegraff Kimberly A. , Umaña-Taylor Adriana J. , Feinberg Mark E. 
Published: September 2024

Siblings are children’s most frequent daily companions in middle childhood and these relationships are theorized to be dynamic in nature but are rarely studied in a way that captures their day-to-day variation. Guided by cultural-ecological and relationship perspectives, this study examined the role of older siblings’ familism values and caring roles as predictors of average levels of and day-to-day variation in siblings’ positive and negative exchanges across seven days and tested moderation by child sex. Participants were older ( M = 10.6 years; SD = 0.39; 46.6% female) and younger siblings ( M = 8.2 years; SD = 1.07; 47.2% female) in 307 Latino sibling dyads recruited from 11 elementary schools in the southwestern U.S. Data were collected via home visits with parents, and in afterschool sessions and seven nightly phone calls with siblings. Analyses were conducted using a random variability model in a multilevel structural equation modeling approach. Findings revealed consistent associations between older siblings’ familism values and sibling roles and both average levels of and intraindividual variation in older siblings’ positivity and negativity. For younger siblings, some findings were moderated by child sex with more consistent links to younger sisters’ positivity and negativity than younger brothers’. Discussion highlights how older siblings’ cultural values and roles shape both overall levels of and day-to-day fluctuations in siblings’ exchanges and offers future directions of research.
Analysis of growth pattern of temporal bone pneumatization using 3D reconstructed computed tomography
Authors: Song Sun Wha , Jun Beom Cho 
Published: September 2024

Background Temporal bone pneumatization (TBP) is influenced by age, sex, and race, and it seems to progress rapidly to puberty. However, the extent of TBP in childhood remains unclear. Purpose To investigate the progression of TBP in children aged 1–18 years via three-dimensional (3D) reconstruction of high-resolution computed tomography (CT) images. Material and Methods A total of 432 temporal bones of 216 individuals aged 1–18 years with well-pneumatized mastoid antra on both sides were included in this retrospective work. We created 18 age groups, each with six boys and six girls. Surface rendering of air density was performed using −290 HU to obtain TBP. Statistical analysis employed SPSS version 24.0 software (IBM Corp., Armonk, NY, USA). Results The linear regression equations that considered age and volume for all cases (ya), male (ym) and female (yf) were ya = 384.42x + 1790.40, R2 = 0.425; ym = 431.54x + 1440.9, R2 = 0.501; and yf = 337.26 x + 2140.5, R2 = 0.355. Both male and female individuals showed an increase in the average value of pneumatization until the age of 17, and the values ​​of pneumatization at specific ages for boys and girls showed differences. The mean male and female TBP levels differed significantly at 3, 11, and 18 years of age ( P < 0.05). Conclusion TBP in boys was greater than that of girls at adolescence. It was possible to identify the specific periods of significant variation in the degree of pneumatization of temporal bone.