bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winter chilling speeds spring development of temperate butterflies
Authors: Stålhandske Sandra , Gotthard Karl , Leimar Olof 
Published: May 2017

Summary

Understanding and predicting phenology has become more important with ongoing climate change and has brought about great research efforts in the recent decades. The majority of studies examining spring phenology of insects have focussed on the effects of spring temperatures alone.

Here we use citizen‐collected observation data to show that winter cold duration, in addition to spring temperature, can affect the spring emergence of butterflies. Using spatial mixed models, we disentangle the effects of climate variables and reveal impacts of both spring and winter conditions for five butterfly species that overwinter as pupae across the UK, with data from 1976 to 2013 and one butterfly species in Sweden, with data from 2001 to 2013.

Warmer springs lead to earlier emergence in all species and milder winters lead to statistically significant delays in three of the five investigated species. We also find that the delaying effect of winter warmth has become more pronounced in the last decade, during which time winter durations have become shorter.

For one of the studied species, Anthocharis cardamines (orange tip butterfly), we also make use of parameters determined from previous experiments on pupal development to model the spring phenology. Using daily temperatures in the UK and Sweden, we show that recent variation in spring temperature corresponds to 10–15 day changes in emergence time over UK and Sweden, whereas variation in winter duration corresponds to 20 days variation in the south of the UK versus only 3 days in the south of Sweden.

In summary, we show that short winters delay phenology. The effect is most prominent in areas with particularly mild winters, emphasising the importance of winter for the response of ectothermic animals to climate change. With climate change, these effects may become even stronger and apply also at higher latitudes.
Four Decades of “Discreet” Charismata: The Catholic Apostolic Church in Australia 1863–1900
Authors: Elliott Peter 
Published: May 2017

For some years, the historiography of Australian Pentecostalism has been dominated by the belief that Pentecostalism came to Australia in 1909 through the agency of Sarah Jane Lancaster who had, in turn, been influenced by news of overseas events. There had, apparently, been little or no influence in the Australian context by such groups as the Catholic Apostolic Church, which formed in Britain in 1835, in the wake of Edward Irving's proto‐Pentecostal theology. Although members of the Catholic Apostolic Church arrived in Melbourne in the 1850s, the general view was that they had by then abandoned their earlier pursuit of the charismata.In 2012, I argued (based on a limited sample of evidence) that the adherents of the Catholic Apostolic Church in Australia both taught and practised the charismata throughout the second half of the nineteenth century. This evidence is contained in the Angels’ Report Books, located in Bradford, West Yorkshire. Since then, the Bradford collection has been fully digitised, thereby allowing a comprehensive review of the Catholic Apostolic Church's charismatic activity and further evaluation of the Lancaster hypothesis.The significance of this research is that it allows a considerable re‐framing of the pre‐history of Australian Pentecostalism, demonstrating that the Catholic Apostolic Church taught and practised glossolalia, prophecy and divine healing through the last four decades of the nineteenth century.
Veligers of the invasive bivalveLimnoperna fortuneiin the diet of indigenous fish larvae in a eutrophic subtropical reservoir
Authors: Paolucci Esteban M. , Leites Valentín , Cataldo Daniel H. , Boltovskoy Demetrio 
Published: May 2017

AbstractLarval fish development depends largely on their ability to capture and ingest food items, and on food availability. In this context, invasive species, eutrophication and river impoundments have complex impacts on fish larvae. Using samples collected in 2005–2009 in the Salto Grande reservoir (Argentina–Uruguay), periodically affected by cyanobacterial blooms, we studied the impact of the larvae of the exotic bivalve Limnoperna fortunei (Dunker, 1857) (Bivalvia) on larval fish diets. Compared with other nearby waterbodies, the abundance of fish larvae was scarcer in the reservoir, especially during algal bloom periods. Only 20% of the larval fish with gut contents fed on L. fortunei veligers. Seven fish taxa (of a total of 12) consumed veligers of L. fortunei, but only two showed a preference for this prey. Taxonomic changes in the larval fish assemblages due to the river's impoundment, and temporal uncoupling between veliger densities (affected by the toxigenic effects of Microcystisspp.) and ichthyoplankton could account for the comparatively low trophic importance of the invasive bivalve's veligers. These results reflect the complexity of interactions brought about when the same invasive species invades different environments, underscoring that the impacts involved depend as much on the invader, as on the regional and ecological settings of the area invaded.
Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro‐labour mediators OA
Authors: Liong Stella , Lim Ratana , Barker Gillian , Lappas Martha 
Published: May 2017

ProblemIntrauterine infection caused by viral infection has been implicated to contribute to preterm birth. Hepatitis A virus cellular receptor 2 (HAVCR2) regulates inflammation in non‐gestational tissues in response to viral infection.Method of studyThe aims of this study were to determine the effect of: (i) viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on HAVCR2 expression; and (ii) HAVCR2 silencing by siRNA (siHAVCR2) in primary amnion and myometrial cells on poly(I:C)‐induced inflammation.ResultsIn human foetal membranes and myometrium, HAVCR2 mRNA and protein expression was decreased when exposed to poly(I:C). Treatment of primary amnion and myometrial cells with poly(I:C) significantly increased the expression and release of pro‐inflammatory cytokines TNF, IL1A, IL1B and IL6; the expression of chemokines CXCL8 and CCL2; the expression and secretion of adhesion molecules ICAM1 and VCAM1; and PTGS2 and PTGFR mRNA expression and the release of prostaglandin PGF2α. This increase was significantly augmented in cells transfected with siHAVCR2. Furthermore, mRNA expression of anti‐inflammatory cytokines IL4 and IL10 was significantly decreased.ConclusionCollectively, our data suggest that HAVCR2 regulates cytokines, chemokines, prostaglandins and cell adhesion molecules in the presence of viral infection. This suggests a potential for HAVCR2 activators as therapeutics for the management of preterm birth associated with viral infections.
Treating acute promyelocytic leukaemia in Latin America: lessons from the International Consortium on Acute Leukaemia experience
Authors: Corrêa de Araujo Koury Luisa , Ganser Arnold , Berliner Nancy , Rego Eduardo M. 
Published: May 2017

SummaryThe Latin Americas and Caribbean are regions where social exclusion and inequality persist as the main obstacles to human development and improvement of health conditions, despite economic growth and social development. These countries need to establish international collaborations with the goal of improving health conditions. In this scenario Acute Promyelocytic Leukaemia (APL), a disease with a high cure rate in developed countries and high prevalence in young patients, offers an ideal opportunity to implement measures with educational and cooperative scope. We discuss the experience of Latin America and the Caribbean through a common network, the International Consortium on Acute Promyelocytic Leukaemia (IC‐APL).
Numerical and functional defects in CD8+CD28− T‐suppressor lymphocytes from patients with primary immune thrombocytopenia
Authors: Li Huiyuan , Hao Yating , Zhang Donglei , Liu Wenjie , Li Yang , Lyu Mingen , Fu Rongfeng , Xue Feng , Liu Xiaofan , Yang Renchi 
Published: May 2017

SummaryPrimary immune thrombocytopenia (ITP) is an acquired autoimmune disorder, and loss of immune tolerance has been implicated in ITP pathogenesis. CD8+CD28− suppressor (Ts) cells have an immunosuppression function and are involved in several autoimmune disorders. However, the role of Ts cells in ITP is currently not clear. Here, flow cytometry was used to detect the CD8+CD28−CD127− proportion, which was decreased in active ITP patients compared with that of controls. Function analysis showed that immunosuppression of CD8+CD28− Ts cells in ITP patients was impaired. Mechanistic studies have shown that CD8+CD28− Ts cells from controls can downregulate CD80 and upregulate LILRB4 (ITL3) and LILRB2 (ILT4) expression on CD14+ monocytes, whereas these abilities were not found in Ts cells from ITP patients. Furthermore, Inducible T‐cell costimulatory (ICOS) expression on the Ts cell surface after activation was decreased whereas programmed death 1 and interleukin 10 expression was not changed in ITP patients compared with those of controls. In summary, the down‐regulated quantity and function of Ts cells in active patients indicated that a Ts defect was involved in ITP. Moreover, decreased ICOS expression and the loss of the ability to regulate co‐stimulator expression on antigen‐presenting cells partly explained the defective Ts‐mediated suppression.
Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease
Authors: Möckesch Berenike , Connes Philippe , Charlot Keyne , Skinner Sarah , Hardy‐Dessources Marie‐Dominique , Romana Marc , Jumet Stéphane , Petras Marie , Divialle‐Doumdo Lydia , Martin Cyril , Tressières Benoît , Tarer Vanessa , Hue Olivier , Etienne‐Julan Maryse , Antoine Sophie , Pialoux Vincent 
Published: May 2017

SummaryOxidative stress and haemolysis‐associated nitric oxide (NO) depletion plays a crucial role in the development of vasculopathy in sickle cell anaemia (SS). However it remains unknown whether oxidative stress and haemolysis levels influence vascular function in patients with sickle haemoglobin C disease (SC). Microvascular response to heat (using Laser Doppler flowmetry on finger), oxidative stress biomarkers, NO metabolites, endothelin‐1 and haematological parameters were compared between patients with SS and SC. Vascular function, oxidative and nitrosative markers were also measured in healthy (AA) children. SS and SC had increased plasma advanced oxidation protein products (AOPP), malondialdehyde, plasma antioxidant activities and NO end products, compared to AA. SC had lower catalase activity compared to AA and SS. Haemolytic rate, glutathione peroxidase and nitrotyrosine concentrations were significantly increased in children with SS compared to SC and AA. SS and SC had impaired microvascular reactivity compared to AA. In SS, the plateau phase of the response to local thermal heating was negatively associated with nitrotyrosine and AOPP. No association between vascular function parameters and oxidative stress markers was observed in SC. Mild haemolysis in SC, compared to SS, may limit oxidative and nitrosative stress and could explain the better preserved microvascular function in this group.
Implementation of National Institute for Health and Care Excellence (NICE) guidance to measure immunoglobulin A with all coeliac screens: can an affordable solution be devised?
Authors: Mac Lochlainn D J , Hira-Kazal R , Varney H , Maher J 
Published: May 2017

Summary
There has been a dramatic increase in requests for coeliac disease (CD) serological screening using immunoglobulin (Ig)A tissue transglutaminase antibodies (IgA-tTG). Recently, the UK National Institute for Health and Care Excellence has revised its guidance, recommending that total IgA should also be measured in all samples. This is justified, as false-negative results may occur with IgA deficiency. However, implementation of this guidance will incur considerable expense. Tests that measure IgA-tTG antibodies can detect IgA deficiency, indicated by low background signal. This provides an opportunity to identify samples containing IgA ≤ 0·2g/l, obviating the need for unselected IgA measurement. We investigated the feasibility of this approach in two centres that use the EliA™ Celikey™ assay or QUANTA Lite® enzyme-linked immunosorbent assay to quantify IgA-tTG antibodies. In both cases, total IgA correlated strongly with background IgA-tTG assay signal. Using the Celikey™ assay, a threshold of &lt; 17·5 response units achieved 100% sensitivity (95% confidence intervals 79·4–100%) for detection of IgA ≤ 0·2g/l, circumventing the need for IgA testing in &gt; 99% of sera. A similar principle was demonstrated for the QUANTA Lite® assay, whereby a threshold optical density of &lt; 0·0265 also achieved 100% sensitivity (95% confidence intervals 78·2–100%) for IgA ≤ 0·2 g/l, avoiding unnecessary IgA testing in 67% of cases. These data suggest that CD screening tests can identify samples reliably containing low IgA in a real-life setting, obviating the need for blanket testing. However, this approach requires careful individualized validation, given the divergent efficiency with which assays identify samples containing low IgA.
Sarsasapogenin‐AA13 ameliorates Aβ‐induced cognitive deficits via improving neuroglial capacity on Aβ clearance and antiinflammation
Authors: Huang Cui , Dong Dong , Jiao Qian , Pan Hui , Ma Lei , Wang Rui 
Published: May 2017

SummaryAimsSarsasapogenin has been reported to improve dementia symptoms somehow, probably through modulating the function of cholinergic system, suppressing neurofibrillary tangles, and inhibiting inflammation. However, the role of sarsasapogenin in response to beta‐amyloid (Aβ) remains to be delineated. This study aimed to determine the therapeutic effect of sarsasapogenin‐13 (AA13, a sarsasapogenin derivative) on learning and memory impairments in Aβ‐injected mice, as well as the role of AA13 in neuroglia‐mediated antiinflammation and Aβ clearance.MethodsFocusing on the role of AA13 in regulating glial responses to Aβ, we conducted behavioral, morphological, and protein expression studies to explore the effects of AA13 on Aβ clearance and inflammatory regulation.ResultsThe results indicated that oral administration of AA13 attenuated the memory deficits of intracerebroventricular (i.c.v.) Aβ‐injected mice; also, AA13 protected neuroglial cells against Aβ‐induced cytotoxicity. The further mechanical studies demonstrated that AA13 reversed the upregulation of proinflammatory M1 markers and increased the expression of antiinflammatory M2 markers in Aβ‐treated cells. Furthermore, AA13 facilitated Aβ clearance through promoting Aβ phagocytosis and degradation. AA13 modulated the expression of fatty acid translocase (CD36), insulin‐degrading enzyme (IDE), neprilysin (NEP), and endothelin‐converting enzyme (ECE) in neuroglia.ConclusionThe present study indicated that the neuroprotective effect of AA13 might relate to its modulatory effects on microglia activation state, phagocytic ability, and expression of Aβ‐degrading enzymes, which makes it a promising therapeutic agent in the early stage of Alzheimer's disease (AD).
Redefining the Role of Admixture and Genomics in Species Conservation
Authors: vonHoldt Bridgett M. , Brzeski Kristin E. , Wilcove David S. , Rutledge Linda Y. 
Published: May 2017

AbstractThe generation of genome‐wide sequence data has brought with it both exciting opportunities for conservation and challenges for determining appropriate management practices in the face of complex evolutionary histories. Genomic data can provide deep insight into taxa with complex evolutionary origins, and is a powerful tool for biologists to obtain a more complete view of ancestry. Many policy decisions are encumbered by patterns of gene flow between species that reveal complex evolutionary histories. Here, we review conservation decisions in admixed species and highlight genomics research that demonstrates the commonality of hybridization in wildlife. We encourage a shift toward a web‐of‐life framework with emphasis on the need to incorporate flexibility in conservation practices by establishing a policy for lineages of admixed ancestry. In particular, we promote a conceptual framework under which hybridization, even extensive hybridization, no longer disqualifies a species from protection; instead, we encourage customized case‐by‐case management to protect evolutionary potential and maintain processes that sustain ecosystems.
A review of multiaxial fatigue criteria for random variable amplitude loads
Authors: Carpinteri A. , Spagnoli A. , Vantadori S. 
Published: May 2017

AbstractNowadays, the estimation of fatigue life under multiaxial random loading is still an extremely complex task. In this paper, a comprehensive review of the multiaxial random fatigue criteria available in the literature is presented. Such a review is mainly devoted to stress‐based criteria for the evaluation of fatigue life in high‐cycle regime. Time and frequency domain approaches are examined. The focus of this paper is related to uniform stress/strain distribution, but also the effect of stress/strain gradient is tangentially addressed. More than 200 references are cited.
Empirical estimation of recreational exploitation of burbot, Lota lota, in the Wind River drainage of Wyoming using a multistate capture–recapture model
Authors: Lewandoski S. A. , Guy C. S. , Zale A. V. , Gerrity P. C. , Deromedi J. W. , Johnson K. M. , Skates D. L. 
Published: May 2017

AbstractBurbot, Lota lota (Linnaeus), is a regionally popular sportfish in the Wind River drainage of Wyoming, USA, at the southern boundary of the range of the species. Recent declines in burbot abundances were hypothesised to be caused by overexploitation, entrainment in irrigation canals and habitat loss. This study addressed the overexploitation hypothesis using tagging data to generate reliable exploitation, abundance and density estimates from a multistate capture–recapture model that accounted for incomplete angler reporting and tag loss. Exploitation rate μ was variable among the study lakes and inversely correlated with density. Exploitation thresholds μ40 associated with population densities remaining above 40% of carrying capacity were generated to characterise risk of overharvest using exploitation and density estimates from tagging data and a logistic surplus‐production model parameterised with data from other burbot populations. Bull Lake (μ = 0.06, 95% CI: 0.03–0.11; μ40 = 0.18) and Torrey Lake (μ = 0.02, 95% CI: 0.00–0.11; μ40 = 0.18) had a low risk of overfishing, Upper Dinwoody Lake had intermediate risk (μ = 0.08, 95% CI: 0.02–0.32; μ40 = 0.18) and Lower Dinwoody Lake had high risk (μ = 0.32, 95% CI: 0.10–0.67; μ40 = 0.08). These exploitation and density estimates can be used to guide sustainable management of the Wind River drainage recreational burbot fishery and inform management of other burbot fisheries elsewhere.
The association of medications with sedative properties with oral health behaviour in community‐dwelling older people
Authors: Tiisanoja A , Syrjälä A‐M , Komulainen K , Hartikainen S , Taipale H , Knuuttila M , Ylöstalo P 
Published: May 2017

AbstractObjectivesThe objective of this study was to determine whether drugs with sedative properties are related to oral health behaviour—such as frequency of toothbrushing, using toothpaste and dental visits—and oral hygiene, measured by the number of teeth with dental plaque, among community‐dwelling older people.MethodsThe study population consisted of 159 community‐dwelling, dentate, non‐smoking, older people from the Oral Health GeMS study (Geriatric Multidisciplinary Strategy for the Good Care of Older People study). The data were collected by interviews and clinical examinations during 2004‐2005. Sedative properties of drugs were assessed using the sedative load (SL) model. Logistic and Poisson regression models were used to estimate odds ratios/relative risks (OR/RR) and 95% confidence intervals (CI).ResultsAfter adjusting for confounding factors, SL associated with infrequent toothbrushing (OR 1.72, CI: 0.61‐4.89), toothpaste use less than twice a day (OR 3.34, CI: 1.39‐8.12), non‐regular dental visits (OR 2.28 CI: 0.91‐5.30) and the number of teeth with dental plaque (RR 1.20 CI: 1.04‐1.39) compared to participants without a SL.ConclusionsThe results of this study suggest that use of drugs with sedative properties indicates poor oral health behaviour among older people.
Communicating social support during crises at the farmers’ market: A social exchange approach to understanding customer‐farmer communal relationships
Authors: Garner Benjamin 
Published: May 2017

AbstractThis ethnographic research explores how the social support developed between customers and farmers at a farmers’ market creates an overall culture of community support that bolsters farmers’ viability during times of crisis and ensures that consumers will have access to healthy, high quality local food. This includes the ways customers provide a general culture of support for local farmers, as well as specific acts of support during times of crisis. It also examines the ways farmers support customers through specialized services and assistance with personal issues. This work draws on theory from the social support, social exchange and social resilience literature to interpret the results.
Changing partners in a cheap talk game: Experimental evidence
Authors: Bonroy Olivier , Garapin Alexis , Llerena Daniel 
Published: May 2017

AbstractThis paper considers the effects that the opportunity to change partners has on communication. Our experiment concerns a standard cheap talk game in which a player observes a private forecast before disclosing it (truthfully or untruthfully) in a message that he sends to his partner. Two treatments are applied: in one, each team remains unchanged until the experiment ends; and in the other, players can change their partner. We find that the opportunity to change partners positively affects communication in the relationship. Interestingly, this effect is explained by higher levels of trust in the messages and not by more truthful disclosure of private information.
Hospital admissions for physical health conditions for people with intellectual disabilities: Systematic review
Authors: Dunn Kirsty , Hughes‐McCormack Laura , Cooper Sally‐Ann 
Published: May 2017

BackgroundPeople with intellectual disabilities may have inequalities in hospital admissions compared with the general population. The present authors aimed to investigate admissions for physical health conditions in this population.MethodsThe present authors conducted a systematic review, searching six databases using terms on intellectual disabilities and hospital admission. Papers were selected based on pre‐defined inclusion/exclusion criteria, data extracted, tabulated and synthesized and quality assessed. PROSPERO registration number: CRD42015020575.ResultsSeven of 29,613 papers were included. There were more admissions, and a different pattern of admissions (more medical and dental), for people with intellectual disabilities, but most studies did not take account of higher disease prevalence. Three papers considered admissions for ambulatory care‐sensitive conditions, two of which accounted for disease prevalence (asthma, diabetes) and found higher admission rates for people with intellectual disabilities.ConclusionAdmissions are common. Asthma and diabetes admission data suggest suboptimal primary health care for people with intellectual disabilities compared with the general population, but evidence is limited.