bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Phytochemicals in Methanolic Extract of Hypnea musciformis (Wulf.) Lamouroux Collected from Manapad in the South East Coast of Tamil Nadu, India
Authors: John Peter Paul J , Fredrick Raja E 
Published: September 2024

The present study was carried out to evaluate the phytochemicals in the methanolic extract of Hypnea musciformis (Wulf.) Lamouroux collected from Manapad in the south east coast of Tamil Nadu, India. The phytochemical screening of methanolic extract was studied using the standard procedure by UV-Visible spectroscopic, HPLC and FTIR. The UV-Visible spectrum showed the compounds separated at the nm of 300, 350, 420, 460, 534.5, 538.5, 606.35 646 and 667.5 with the absorption 0.361, 0.249, 0.675, 4.000, 0.967, 0.098, 1.260, 2.460 and 2.571 respectively. The qualitative HPLC fingerprint profile displayed six compounds at different retention time of 1.923min, 2.140min, 2.533min, 3.017min, 3.260min and 3.525min. The result of FTIR analysis was found the presence of functional groups such as amides, phosphorus compound, alcohols, phenols and halogen compounds.
Keywords: Phytochemicals, Hypnea musciformis, UV-Visible, HPLC, FTIR
Physico-Chemical Analysis of Water at Selected Point in Kota, Rajasthan
Authors: Chouhan Rajeev K , Bansal Anil K , Chhipa R C 
Published: September 2024

Water is the basic unit of life and it is essential element for all living forms and the environment health. Water is the basic unit of life and it is essential element for all living forms and the environment health. Rivers are essential for all living organism on earth. In this study, we screened the point of contamination of pollutants in Chambal river water and their concentration in different season. Present study revealed that water quality parameters (pH, EC, Chloride, Fluoride, TDS, DO, COD, BOD etc) of some sample site showed contamination and depletion in quality of Chambal River in pre monsoon. The water quality was maintained in certain sample site and all parameters were found under limit. We should maintain quality of water because Chambal River is major source of drinking water for districts of Rajasthan.
Keywords: Water quality, Chambal River, Chemical parameter
A Review on Multi Approaches for Impurity Isolation and its Characterization
Authors: Prajapati Pintu B. , Wankhed Navneet , Mehta Priti J. 
Published: September 2024

International Conference on Harmonization (ICH) has formulated different guideline regarding the control of impurities. In this review, the impurity sources, classification, isolation, detection and characterization methods are described. The some impurities are unavoidable and will be present in trace amounts hence ICH guidelines frame the different policies and establish the specification limits, isolation and characterization is necessary for evaluation and control of impurities. The other regulatory bodies and drug development authorities look up to these guidelines for launching a quality drug into the market. Validation of analytical process for impurity identification is performed to establish the impurity profile of any drug substance. Hence the major focus of this review article is on isolation and characterization of impurities using various technics, sources and classifications, establishment of impurity profile and analytical approaches to establish its profile. We also could apply the QbD to providing statistical documentary evidences.
Keywords: Impurity profile, Impurities isolation methods, chromatographic separation, Impurity Characterization, ICH, QbD.
“And it’s even better for us, let there be three, five churches!”: The St. Nicholas Churches of Mednogorsk
Authors: Gramatchikova Natalia 
Published: September 2024

The article is based on field material collected in Mednogorsk (Orenburg region) in December 2021. It is dedicated to the study of the interactions between the religious and cultural landscapes of the city. A distinctive feature of industrial Mednogorsk, founded during the era of industrialization, is its “church history” of the Soviet era. An constant element of this history was the life of the parish, which since 1943 took place in a prayer house later converted into the church of St. Nicholas the Wonderworker. The decades-long existence of the so-called “old St. Nicholas Church” in the city havs led to the enrichment and complication of the religious landscape, which includes hidden public practices of faith protection and places of prayer. The latter include an episode of collective protection of the church from destruction in 1961 and the book by Vera Popova, who became recognized in the city as the “historian of the temple” from among the oldest parishioners. The article provides a comparative analysis of the oral and written versions of the history of St. Nicholas Church. In 2007, the new Church of St. Nicholas the Wonderworker was consecrated in Mednogorsk. The authors analyze the distribution of functions between the two St. Nicholas churches in the small town in the post-Soviet period. The conclusion is drawn about the interpenetration of the historical, cultural and religious heritage of the city, which originated as a settlement near a copper-sulfur plant. Additionally, it is suggested that the church component of Mednogorsk’s history allows for the interpretation of its Soviet period as an alternative version of Soviet industrialization in a small factory town.
Formação de alunos-leitores: um olhar sobre nossas práticas de mediação
Authors: Branchi Natália , Alves Izandra 
Published: September 2024

São muitas as ações promovidas pelos servidores/as do IFRS, Campus Feliz, que colocam os livros, as leituras e os leitores, constantemente, no centro do debate. Da mesma forma, professores/as da área das linguagens trabalham, constantemente, a leitura do texto literário em suas aulas. Assim, este artigo traz percepções a partir de um projeto de pesquisa[1] A formAção de alunos - leitores no IFRS, Campus Feliz: um olhar sobre nossas práticas de mediação que investigou, através de um questionário semiestruturado, junto aos alunos concluintes do Ensino Médio Técnico (4º anos) e do curso de Licenciatura em Letras Português e Inglês (7º e 8º semestres), da referida instituição, como os/as estudantes perceber am o movimento da leitura e dos livros em sua formação leitora, durante o tempo em que estiveram na instituição e se, de alguma maneira, estas atividades influenciaram em seus gostos/escolhas/vontades para a leitura. Como aporte teórico, nos valemos, principalmente, dos estudos de Rildo Cosson, Jorge Larrosa, Marisa Lajolo e Maria do Rosário Mortatti Magnani acerca da formação de leitores, da escolarização da literatura e do letramento literário. Como resultados principais, destacamos que 65% dos alunos diz em ser leitores e que seus/suas professores/as contam histórias, realizam seminários e debates avaliativos. Quanto às ações promovidas por distintos projetos, 74% afirmam não participar. Assim, avalia-se a necessidade de melhorar as proposições, tanto dos professores quanto dos projetos de modo geral, a fim de interferir positivamente na formação de alunos leitores.

[1]Projeto de Pesquisa vinculado ao Edital nº 13, de 09 de maio de 2022, do IFRS, Campus Feliz.
Análise das práticas de oralidade presentes no material didático do 2º ano de língua portuguesa do Programa Educar pra Valer à luz da perspectiva dialógica da linguagem
Authors: Gonçalves Patrícia Figueiredo , Jardim Silvia Regina Marques 
Published: September 2024

Neste artigo, compartilhamos parte dos resultados de uma investigação de mestrado que buscou compreender o diálogo entre as práticas e eventos de letramento sob a perspectiva dialógica da linguagem e o material didático do 2º ano de Língua Portuguesa do Programa Educar pra Valer. O foco deste texto foi a categoria oralidade para responder a seguinte pergunta de pesquisa: como as crianças se expressam na proposta de interação verbal presente no material didático do 2º ano de Língua Portuguesa do Programa Educar pra Valer? Como abordagem metodológica a pesquisa foi qualitativa. Os dados foram produzidos por meio da análise documental. Como objetivo pretendeu: analisar, a partir de uma perspectiva dialógica, as práticas de oralidade presentes no material didático de Língua Portuguesa do 2º ano do Programa Educar pra Valer. O estudo teve como base a concepção dialógica da linguagem sob a perspectiva da teoria de Bakhtin (2012), para compreender a linguagem como prática social, histórica, cultural e dialógica. O estudo revelou que as práticas de oralidade são pouco exploradas no sentido de a criança construir significados. Pois, são conduzidas pelas orientações didáticas destinadas à professora, carregada de uma intenção pedagógica comprometida apenas com a aprendizagem da linguística/gramática. Como mostra a análise, o estímulo à oralidade é moldado por orientações e intenções pedagógicas que não conduzem a criança à construção de sentidos.

Palavras-chave: Programa Educar pra Valer; Práticas de oralidade; Perspectiva dialógica da linguagem.
Associations of Diabetes and Prediabetes With Mortality and Life Expectancy in China: A National Study
Authors: Tian Yunli , Qiu Zixin , Wang Feixue , Deng Shan , Wang Yue , Wang Zi , Yin Peng , Huo Yong , Zhou Maigeng , Liu Gang , Huang Kai 
Published: September 2024

OBJECTIVE
To investigate the excess mortality and life-years lost associated with diabetes and prediabetes in China.

RESEARCH DESIGN AND METHODS
This national cohort study enrolled 135,405 participants aged 18 years or older from the general population in China. Cox proportional hazards regression models were used to estimate adjusted mortality rate ratio (RR). The life table method was used to estimate life expectancy.

RESULTS
Among the 135,405 participants, 10.5% had diabetes and 36.2% had prediabetes in 2013. During a median follow-up of 6 years, 5517 deaths were recorded, including 1428 and 2300 deaths among people with diabetes and prediabetes, respectively. Diabetes and prediabetes were significantly associated with increased risk of all-cause (diabetes: RR, 1.61 [95% CI 1.49, 1.73]; prediabetes: RR, 1.08 [95% CI 1.01, 1.15]), and cardiovascular disease (diabetes: RR, 1.59 [95% CI 1.41, 1.78]; prediabetes: RR, 1.10 [95% CI 1.00, 1.21]) mortality. Additionally, diabetes was significantly associated with increased risks of death resulting from cancer, respiratory disease, liver disease, and diabetic ketoacidosis or coma. Compared with participants with normoglycemia, life expectancy of those with diabetes and prediabetes was shorter, on average, by 4.2 and 0.7 years at age 40 years, respectively. The magnitude of the associations of diabetes and prediabetes with all-cause and cardiovascular disease mortality varied by age and residence.

CONCLUSIONS
In this national study, diabetes and prediabetes were significantly associated with reduced life expectancy and increased all-cause and cause-specific mortality risks. The disparities in excess mortality associated with diabetes and prediabetes between different ages and residences have implications for diabetes and prediabetes prevention and treatment programs.
Bringing data to life: A model for involving lived experience in data-driven research
Authors: McKenna Sarah , Nelson Elizabeth , Maguire Aideen 
Published: September 2024

ObjectiveIt is generally accepted that involving experts by experience is necessary to deliver research that is relevant to community need and to progress the data democratisation agenda. We have piloted and evaluated a model of co-production for data-driven research with seldom heard groups.
ApproachIn partnership with the charity Voice of Young People in Care (VOYPIC) and a group of care experienced young people, the Administrative Data Research Centre Northern Ireland (ADRC NI) piloted and implemented a model of co-production in data-driven research. To evaluate the model, interviews were conducted with the young people, staff at VOYPIC, and ADRC NI researchers and public engagement team members.
ResultsThematic analysis of interview data identified numerous benefits and barriers to co-producing data-driven research with experts by experience. We offer reflections from three perspectives (the young people, VOYPIC and ADRC NI), as well as a model that can be adapted with different lived experience groups in other data-driven research programmes.
Conclusion Experts by experience can be equal partners in most stages of the data research cycle, and there are tangible benefits for all partners and the research itself. However, aligning the aspirational principles of co-production with the realities of delivering data research is challenging and has implications for achieving the democratisation of data.
ImplicationsThis session will share real world perspectives on the co-production of data research with seldom heard groups.
Development of a dictionary of information items inspired by common data models to support health research data access requests
Authors: Whyte Carrie-Anne , La Carmen , Anis Ali , Yang David , Ethier Jean-François , McGilchrist Mark 
Published: September 2024

A network of organizations collaborates to provide services to facilitate multi-regional research across Canada. To streamline the data access process, the network is developing a dictionary of information items (InfoItems), providing a label and definition that represent a semantic sourced from an ontology (e.g., “human birth date” from a demography ontology). This allows for a standardized and shareable means to express data requirements.
Inspired by health-research common data models (CDMs) like those from the Observational Medical Outcomes Partnership (OMOP) and the Canadian Network for Observational Drug Effects (CNODES), approximately 60 InfoItems were developed by the network. As a pilot exercise, four data centres mapped their data assets to the InfoItems to ensure they are relevant to the Canadian health data context. This has laid the foundation for InfoItems as a basic data harmonization mechanism.
The new InfoItems-based data dictionary promotes the standardization of data asset contents across the network’s data centres. Researchers can use the dictionary to specify a project’s data requirements, establishing details like data availability across multiple regions, for inclusion in their data access request.
The InfoItems dictionary is pivotal in simplifying data access requests, promoting multi-regional research in Canada. This resource can simultaneously safeguard the quality of analytical results and optimize data extraction into existing data models (e.g., health-research CDMs). Ongoing improvements in this area aim to enhance user experience and facilitate quality research.
Maternal immigrant status and survival among children with congenital heart disease
Authors: Miao Qun (Grace) , Dunn Sandra , Wen Shi-Wu , Lougheed Jane , Griffiths Rebecca , Lavin Venegas Carolina , Velez Maria , Walker Mark 
Published: September 2024

ObjectiveTo examine associations between maternal immigrant status and survival of children with congenital heart disease (CHD).
ApproachA retrospective population-based cohort study of hospital live births between April 2002 to September 2020 in Ontario, Canada was conducted at ICES. We identified children aged 0-17 years with a diagnosis of CHD from inpatient and health services datasets. The exposure was maternal immigrant status obtained from the IRCC permanent resident database. The outcome was time-to-death from after birth to <18 years olds. Multilevel Cox hazard regression models generated hazard ratios (HR) for associations between maternal immigrant status and children’s deaths while accounting for hospitals as a cluster factor and adjusting for maternal age at birth, neighbourhood income and education quantiles, comorbidities, a composite of severe maternal morbidity, gestational age at birth, birth weight, and infant sex.
ResultsRelative to children born to non-immigrant mothers, the adjusted HR for death was 1.17 (95% CI:1.06-1.30) in children whose mothers were immigrants, and 1.33 (95% CI:1.07-1.65) in those from refugees. Moreover, compared to children residing in neighbourhoods with the highest income and educational levels, the adjusted HR of death for children who lived in neighbourhoods with the lowest income and educational level was 1.52 (95% CI: 1.24-1.88) and 1.47 (95% CI: 1.18-1.83) respectively.
ConclusionChildren with CHD born to immigrant and refugee mothers, and those living in low socioeconomic status neighbourhoods had worse mortality. Health policy decision makers should target children with CHD from immigrant/refugee families and disadvantaged neighbourhoods to improve their survival.
A governance framework for facilitating cross-agency data sharing
Authors: O'Sullivan Katherine , Lumsden Joanne , Anderson Caroline , Black Corri , Ball William , Wilde Katie 
Published: September 2024

Linking data across local authorities and health boards has the potential to reduce inequalities and improve outcomes. However, cross-agency data sharing leads to complexities around data ownership, legal conditions for processing, organisational controls and risk assessments to ensure privacy and confidentiality of subjects whilst facilitating research and service improvements. We share a governance framework for cross-agency data sharing between a local authority and regional health board in Scotland.
A cross-sector Child Neglect working group was established with representation from public sector agencies, the NHS, University researchers and a Trusted Research Environment to support research on children’s mental health prescribing and secondary specialist services provision and linking to the Aberdeen City Council Child Protection Register. Lessons learned were captured throughout the governance, data transfer and data linkage phases.
Communication is the most important driver, with key individuals, deputies and routes of escalation agreed and involved throughout for clarity of roles and expectation setting. Key lessons learned include requiring input from all parties at the project initiation stage, particularly IG teams, including agreements on necessary templates. Knowledge exchange is required between the research team, data owners and data processors to ensure research protocol requirements are correctly understood and data transfer is supported. If possible, internal and/or external validation of data should also be performed before data is linked.
Cross-agency data sharing is a vital means to understanding and improving outcomes for individuals and populations. Critical to this is establishing an action plan and formalised project process to achieve outcomes.
Maternal And preGnancy hEalth duriNg elevaTed heAt – MAGENTA: Novel data linkages and methods to understand the impacts of climate change on deprived communities in Wales and London.
Authors: Fry Rich , Owen Rhiannon , Turner Samantha , Mizen Amy , Griffiths Lucy , Hardelid Pia , Thornton Cathy 
Published: September 2024

Background and ObjectivesThe health impacts from changing climate, including increasing frequency, severity, and duration of heat are projected to worsen. The MAGENTA study will explore the impact of heat on pregnancy-related outcomes for deprived communities in Wales and London.
ApproachMAGENTA will create linked data cohorts capturing some of the most deprived and diverse communities in Europe to analyse the impact deprivation, ethnicity, heatwaves, and urban heat islands have on pregnancy-related health. A consented data-linked cohort of pregnant women will provide biological samples and undergo direct measurement of themselves and their home environments to understand the heat stress response of pregnant women not acclimatised to heat during their pregnancy. Core to the study is our public involvement strategy which includes pregnant women and women who have recently delivered a baby, co-producing the research and how results are communicated.
ResultsOur electronic cohorts cover >10 years of climate and health data and capture all births in Wales >300,000 and >1.1 million in London. We will present how the novel data linkages can work in multiple trusted research environments, approaches for sharing methods in geospatial modelling and statistics across the project and preliminary findings from the study.
Findings and ImplicationsThe MAGENTA study will help inform expectant parents, families and policy makers how to prepare for climate change in temperate regions. The comparison between different populations in Wales and London will give insight on where policies and interventions can be generally applied and where they need to be contextually adapted.
Wastewater-Based Surveillance of Substances of Potential Abuse
Authors: Southern Danielle , Ghosh Monty , Harmon Megan , Kuzma Darina , Kormendi Aleshia , Moffett Kayla , Westlund Paul , Hubert Casey , Parkins Michael , Williamson Tyler 
Published: September 2024

ObjectiveAmid a drug poisoning epidemic, UCalgary adapted its comprehensive wastewater monitoring program to track illicit drug use. The joint initiative between the academic community and Alberta municipalities aims to provide early warning information on changes in the drug supply to healthcare workers, policymakers, and people with substance use disorders (pwSUD).
ApproachThe logistic network, first used for SARS-CoV-2 monitoring, has evolved to track 48 substances linked to substance use. These include the parent drugs (e.g., cocaine, methamphetamines, various opiates) and their metabolites. The comprehensive nature of this tracking provides a nuanced understanding of trends. Collected up to 3X-weekly across various locations in Alberta including municipal wastewater treatment plants, entire neighbourhoods, and shelters, the data reveals geographical and temporal patterns in substance use. Findings were cross validated with Alberta’s substance use surveillance system to predict trends in wastewater, correlating with emergency and inpatient admissions and overdose deaths.
ResultsThe research uncovered noteworthy trends. Intermittent, alarming, spikes in carfentanyl, benzodiazepines, and xylazine in wastewater were observed during periods of elevated Emergency Medical Services (EMS) responses to opioid-related incidents in the year 2023. This correlation underscores the real-world impact of the identified substance trends, emphasizing the urgency for targeted interventions to address the escalating opioid crisis. Further work to create a dashboard with additional data sources has begun.
ConclusionsTimely data on the dynamic drug supply is crucial in addressing the ongoing drug poisoning crisis. The team is exploring ways to share information with emergency responders, healthcare providers, government officials, and pwSUD.