bluuebunny/crossref_metadata_2025_split huggingface dataset:
Action communautaire, militantisme et lutte pour la reconnaissance : une réalité historique, politique et sociologique
Authors: Jetté Christian 
Published: August 2017

L’action collective en travail social a toujours constitué un terreau fertile pour le militantisme. Avec ses principes de justice sociale, de solidarité, d’autonomie et de démocratie, l’intervention de type collective et/ou communautaire intègre des revendications à caractère social, économique, culturel et politique. Les intervenants, mais aussi des citoyens et des bénévoles, sont donc appelés, par leur travail et leurs activités, à prendre position, que ce soit de manière implicite ou explicite, et donc à militer sur plusieurs enjeux de nature politique. Ce militantisme participe à l’établissement d’une démocratie plurielle et aux luttes pour la reconnaissance menées par les communautés opprimées ou marginalisées. La « lutte pour la reconnaissance », telle que l’a définie Honneth (2008), permet ainsi de mieux comprendre le rôle des conflits dans les processus d’intégration sociale et la place du militantisme au sein d’une vision transformatrice de la société.
Défense collective des droits sociaux : des modèles d’intervention aux stratégies d’action
Authors: Sauvé Méric , Provencher Ysabel 
Published: August 2017

Au début des années 1970, les travaux de Jack Rothman sur les pratiques en organisation communautaire ont introduit la notion de modèle de pratique en intervention communautaire. À sa classification initiale des modèles de la planification sociale, du développement local et de l’action sociale se sont ajoutées, au fil des décennies, les classifications d’autres auteures et auteurs américains et canadiens. Chacun de ces auteures et auteurs a contribué à caractériser davantage les pratiques d’intervention communautaire traditionnellement associées au domaine de l’action sociale. Les connaissances accumulées permettent aujourd’hui de proposer une classification plus fine des pratiques d’action sociale en fonction de trois stratégies : la stratégie émancipatoire, la stratégie de coopération-persuasion et la stratégie de confrontation.
Nutrient supply, surface currents, and plankton dynamics predict zooplankton hotspots in coastal upwelling systems
Authors: Messié Monique , Chavez Francisco P. 
Published: August 2017

AbstractA simple combination of wind‐driven nutrient upwelling, surface currents, and plankton growth/grazing equations generates zooplankton patchiness and hotspots in coastal upwelling regions. Starting with an initial input of nitrate from coastal upwelling, growth and grazing equations evolve phytoplankton and zooplankton over time and space following surface currents. The model simulates the transition from coastal (large phytoplankton, e.g., diatoms) to offshore (picophytoplankton and microzooplankton) communities, and in between generates a large zooplankton maximum. The method was applied to four major upwelling systems (California, Peru, Northwest Africa, and Benguela) using latitudinal estimates of wind‐driven nitrate supply and satellite‐based surface currents. The resulting zooplankton simulations are patchy in nature; areas of high concentrations coincide with previously documented copepod and krill hotspots. The exercise highlights the importance of the upwelling process and surface currents in shaping plankton communities.
Palladium‐Catalyzed Regioselective Synthesis of 1,2‐Fused Indole‐Diazepines via [5+2] Annulation of o‐Indoloanilines with Alkynes
Authors: Thikekar Tushar Ulhas , Sun Chung‐Ming 
Published: August 2017

AbstractAn efficient and regioselective palladium(II)‐catalyzed [5+2] annulation of unprotected o‐indoloanilines with internal alkynes under microwave irradiation has been explored. The diverse imine‐containing 1,2‐fused indole[1,7‐a]diazepines are constructed in moderate to excellent yields. The mechanistic pathway shows pivalic acid and molecular oxygen to play crucial roles for the regeneration of highly active electrophilic palladium species in the catalytic cycle.magnified image
Treatment of individuals who cannot receive blood products for religious or other reasons
Authors: Scharman Carlton D. , Burger Debora , Shatzel Joseph J. , Kim Edward , DeLoughery Thomas G. 
Published: August 2017

AbstractBy virtue of their religious principles, Jehovah's Witnesses (JWs) generally object to receiving blood products, raising numerous ethical, legal, and medical challenges for providers who care for these patients, especially in the emergent setting. In this review, we discuss several areas relevant to the care of JWs, including the current literature on “bloodless” medical care in the setting of perioperative and intraoperative management, acute blood loss, trauma, pregnancy, and malignancy. We have found that medical and administrative efforts in the form of bloodless medicine and surgery programs can be instrumental in helping to reduce risks of morbidity and mortality in these patients. Planning prior to an anticipated event associated with blood loss or anemia (such as elective surgery, pregnancy, and chemotherapy) is critical. Specifically, bloodless medicine programs should prioritize vigilant early screening and management of anemias, early establishment of patient wishes regarding transfusion, and the incorporation of those wishes into multidisciplinary medical and surgical care. Although there are now a variety of human‐based and nonhuman‐based products available as transfusion alternatives, the degree and quality of evidence to support their use varies significantly between products and is also largely dependent on the clinical setting.
Fluorous Phase‐Directed Peptide Assembly Affords Nano‐Peptisomes Capable of Ultrasound‐Triggered Cellular Delivery
Authors: Medina Scott H. , Michie Megan S. , Miller Stephen E. , Schnermann Martin J. , Schneider Joel P. 
Published: August 2017

AbstractHere, we report the design, synthesis and efficacy of a new class of ultrasound (US)‐sensitive self‐assembled peptide‐based nanoparticle. Peptisomes are prepared via templated assembly of a de novo designed peptide at the interface of fluorinated nanodroplets. Utilizing peptide assembly allows for facile particle synthesis, direct incorporation of bioactive sequences displayed from the particle corona, and the ability to easily encapsulate biologics during particle preparation using a mild solvent exchange procedure. Further, nano‐peptisome size can be precisely controlled by simply modulating the starting peptide and fluorinated solvent concentrations during synthesis. Biomolecular cargo encapsulated within the particle core can be directly delivered to the cytoplasm of cells upon US‐mediated rupture of the carrier. Thus, nano‐peptisomes represent a novel class of US‐activated carriers that can shuttle cell‐impermeable biomacromolecules into cells with spatial and temporal precision.
Enantioselective Phosphine‐Catalyzed Formal [4+4] Annulation of α,β‐Unsaturated Imines and Allene Ketones: Construction of Eight‐Membered Rings
Authors: Ni Huanzhen , Tang Xiaodong , Zheng Wenrui , Yao Weijun , Ullah Nisar , Lu Yixin 
Published: August 2017

AbstractThe first highly enantioselective phosphine‐catalyzed formal [4+4] annulation has been developed. In the presence of amino‐acid‐derived phosphines, the unprecedented [4+4] annulations between benzofuran/indole‐derived α,β‐unsaturated imines and allene ketones proceeded smoothly, thus affording azocines, bearing either a benzofuran or an indole moiety, in excellent yields and with nearly perfect enantioselectivities (≥98 % ee in most cases). This work marks the first efficient asymmetric construction of optically enriched eight‐membered rings by phosphine catalysis.
Anionische Palladium(0)‐ und Palladium(II)‐At‐Komplexe
Authors: Kolter Marlene , Böck Katharina , Karaghiosoff Konstantin , Koszinowski Konrad 
Published: August 2017

AbstractPalladium‐At‐Komplexe gelten als wichtige Zwischenstufen in Heck‐ und Kreuzkupplungsreaktionen, haben sich aber bisher einer Charakterisierung auf molekularer Ebene weitgehend entzogen. Mithilfe der Elektrosprayionisierungs‐Massenspektrometrie, Messungen der elektrischen Leitfähigkeit und NMR‐Spektroskopie wird hier gezeigt, dass der elektronenarme Katalysator [L3Pd] (L=Tris[3,5‐bis(trifluormethyl)phenyl]phosphan) bereitwillig mit Br−zum anionischen, nullwertigen At‐Komplex [L3PdBr]−reagiert. Elektronenreichere Pd‐Katalysatoren weisen dagegen eine geringere Tendenz zur Bildung von At‐Komplexen auf. Die Kombination von [L3Pd] mit LiI und einem Aryliodid ArI führt zur Entstehung des PdII‐At‐Komplexes [L2Pd(Ar)I2]−.
Synthesis and Characterization of Iridium(V) Coordination Complexes With an N,O‐Donor Organic Ligand
Authors: Sharninghausen Liam S. , Sinha Shashi Bhushan , Shopov Dimitar Y. , Mercado Brandon Q. , Balcells David , Brudvig Gary W. , Crabtree Robert H. 
Published: August 2017

AbstractWe have prepared and fully characterized two isomers of [IrIV(dpyp)2] (dpyp=meso‐2,4‐di(2‐pyridinyl)‐2,4‐pentanediolate). These complexes can cleanly oxidize to [IrV(dpyp)2]+, which to our knowledge represent the first mononuclear coordination complexes of IrV in an N,O‐donor environment. One isomer has been fully characterized in the IrV state, including by X‐ray crystallography, XPS, and DFT calculations, all of which confirm metal‐centered oxidation. The unprecedented stability of these IrV complexes is ascribed to the exceptional donor strength of the ligands, their resistance to oxidative degradation, and the presence of four highly donor alkoxide groups in a plane, which breaks the degeneracy of the d‐orbitals and favors oxidation.
C−H Bond Trifluoromethylation of Arenes Enabled by a Robust, High‐Valent Nickel(IV) Complex
Authors: D'Accriscio Florian , Borja Pilar , Saffon‐Merceron Nathalie , Fustier‐Boutignon Marie , Mézailles Nicolas , Nebra Noel 
Published: August 2017

AbstractThe robust, high‐valent NiIV complex [(Py)2NiIVF2(CF3)2] (Py=pyridine) was synthesized and fully characterized by NMR spectroscopy, X‐ray diffraction, and elemental analysis. It reacts with aromatic compounds at 25 °C to form the corresponding benzotrifluorides in nearly quantitative yield. The monomeric and dimeric NiIIICF3 complexes 2⋅Py and 2 were identified as key intermediates, and their structures were unambiguously determined by EPR spectroscopy and X‐ray diffraction. Preliminary kinetic studies in combination with the isolation of reaction intermediates confirmed that the C−H bond‐breaking/C−CF3 bond‐forming sequence can occur both at NiIVCF3 and NiIIICF3 centers.
Compartmentalizing Supramolecular Hydrogels Using Aqueous Multi‐phase Systems
Authors: Mytnyk Serhii , Olive Alexandre G. L. , Versluis Frank , Poolman Jos M. , Mendes Eduardo , Eelkema Rienk , van Esch Jan H. 
Published: August 2017

AbstractA generic method is used for compartmentalization of supramolecular hydrogels by using water‐in‐water emulsions based on aqueous multi‐phase systems (AMPS). By forming the low‐molecular‐weight hydrogel throughout all phases of all‐aqueous emulsions, distinct, micro‐compartmentalized materials were created. This structuring approach offers control over the composition of each type of the compartments by directing the partitioning of objects to be encapsulated. Moreover, this method allows for barrier‐less, dynamic exchange of even large hydrophilic solutes (MW≈60 kDa) between separate aqueous compartments. These features are expected to find use in the fields of, for instance, micro‐structured catalysts, templating, and tissue engineering.
Heavily Substituted Atropisomeric Diarylamines by Unactivated Smiles Rearrangement of N‐Aryl Anthranilamides
Authors: Costil Romain , Dale Harvey J. A. , Fey Natalie , Whitcombe George , Matlock Johnathan V. , Clayden Jonathan 
Published: August 2017

AbstractDiarylamines find use as metal ligands and as structural components of drug molecules, and are commonly made by metal‐catalyzed C−N coupling. However, the limited tolerance to steric hindrance of these couplings restricts the synthetic availability of more substituted diarylamines. Here we report a remarkable variant of the Smiles rearrangement that employs readily accessible N‐aryl anthranilamides as precursors to diarylamines. Conformational predisposition of the anthranilamide starting material brings the aryl rings into proximity and allows the rearrangement to take place despite the absence of electron‐withdrawing substituents, and even with sterically encumbered doubly ortho‐substituted substrates. Some of the diarylamine products are resolvable into atropisomeric enantiomers, and are the first simple diarylamines to display atropisomerism.
Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics
Authors: Chen Yuyan , Cheng Liang , Dong Ziliang , Chao Yu , Lei Huali , Zhao He , Wang Jian , Liu Zhuang 
Published: August 2017

AbstractMultifunctional biodegradable inorganic theranostic nano‐agents are of great interest to the field of nanomedicine. Upon lipid modification, VS2 nanosheets could be converted into ultra‐small VS2 nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to paramagnetism, high near‐infrared (NIR) absorbance, and chelator‐free 99mTc4+ labeling of VS2, such VS2@lipid‐PEG nanoparticles could be used for T1‐weighted magnetic resonance (MR), photoacoustic (PA),and single photon emission computed tomography (SPECT) tri‐modal imaging guided photothermal ablation of tumors. Importantly, along with the gradual degradation of VS2, our VS2@lipid‐PEG nanoparticles exhibit effective body excretion without appreciable toxicity. The unique advantages of VS2 nanostructures with highly integrated functionalities and biodegradable behaviors mean they are promising for applications in cancer theranostics.
Synthesis, density functional theory calculations and luminescence of lanthanide complexes with 2,6‐bis[(3‐methoxybenzylidene)hydrazinocarbonyl] pyridine Schiff base ligand
Authors: Taha Ziyad A. , Ababneh Taher S. , Hijazi Ahmed K. , Abu‐Salem Qutaiba , Ajlouni Abdulaziz M. , Ebwany Shroq 
Published: August 2017

AbstractA pyridine‐diacylhydrazone Schiff base ligand, L = 2,6‐bis[(3‐methoxy benzylidene)hydrazinocarbonyl]pyridine was prepared and characterized by single crystal X‐ray diffraction. Lanthanide complexes, Ln–L, {[LnL(NO3)2]NO3.xH2O (Ln = La, Pr, Nd, Sm, Eu, Gd, Tb, Dy and Er)} were prepared and characterized by elemental analysis, molar conductance, thermal analysis (TGA/DTGA), mass spectrometry (MS), Fourier transform infra‐red (FT‐IR) and nuclear magnetic resonance (NMR) spectroscopy. Ln–L complexes are isostructural with four binding sites provided by two nitro groups along with four coordination sites for L. Density functional theory (DFT) calculations on L and its cationic [LnL(NO3)2]+ complexes were carried out at the B3LYP/6–31G(d) level of theory. The FT‐IR vibrational wavenumbers were computed and compared with the experimentally values. The luminescence investigations of L and Ln–L indicated that Tb–L and Eu–L complexes showed the characteristic luminescence of Tb(III) and Eu(III) ions. Ln–L complexes show higher antioxidant activity than the parent L ligand.
The effect of Benzothiazolone‐2 on the expression of Metallothionein‐3 in modulating Alzheimer's disease
Authors: Roy Sudeep , Gumulec Jaromir , Kumar Akhil , Raudenska Martina , Baig Mohd Hassan , Polanska Hana , Balvan Jan , Gupta Mansi , Babula Petr , Odstrčilík Jan , Choi Inho , Provaznik Ivo , Masarik Michal 
Published: August 2017

AbstractIntroductionMetallothioneins (MTs) are a class of ubiquitously occurring low‐molecular‐weight cysteine‐ and metal‐rich proteins containing sulfur‐based metal clusters. MT‐3 exhibits neuro‐inhibitory activity. The possibility to enhance the expression of MT‐3 or protect it from degradation is an attractive therapeutic target, because low levels of MT‐3 were found in brains of Alzheimer's disease (AD) patients.ObjectivesThe primary objective of this study was to test an enhancement of MT‐3 cellular concentration after MT‐3 binding treatment, which could prevent MT‐3 degradation.MethodsMTT assay, flow‐cytometry, fluorescence microscopy, quantitative real‐time polymerase chain reaction, and immunodetection of MT3 were used for analysis of effect of STOCK1N‐26544, STOCK1N‐26929, and STOCK1N‐72593 on immortalized human microglia‐SV40 cell line.ResultsAll three tested compounds enhanced concentration of MT‐3 protein in cells and surprisingly also mRNA concentration. IC50 values of tested molecules exceeded about ten times the concentration that was needed for induction of MT‐3 expression. The tested compound Benzothiazolone‐2 enhanced apoptosis and necrosis, but it was not of severe effect. About 80% of cells were still viable. There was no serious ROS‐generation and no severe decrease in mitochondria numbers or stress induced endoplasmic reticulum changes after test treatments. The selected compound showed stable hydrophobic and electrostatic interaction during MT‐3 ligand interaction.ConclusionBenzothiazolone‐2 compounds significantly enhanced MT‐3 protein and mRNA levels. The compounds can be looked upon as one of the probable lead compounds for future drug designing experiments in the treatment of Alzheimer's disease.
Matthew baillie's specimens and engravings
Authors: Spear Caitlin , Reilly Maggie , McDonald Stuart W. 
Published: August 2017

In 1799, Matthew Baillie, William Hunter's nephew, published his famous atlas of pathology. It was entitled A Series of Engravings Accompanied with Explanations which are Intended to Illustrate the Morbid Anatomy of Some of the Most Important Parts of the Human Body. The present study aims to match the illustrations to extant specimens in the collections of William and John Hunter, preserved at the University of Glasgow and at the Royal College of Surgeons of England respectively.Baillie's book contains 10 fasciculi, consisting of 73 plates and 206 figures. The specimens Baillie illustrated came from his own collection and those of ten others, including his uncles, William and John Hunter. The book was illustrated by William Clift and engraved by James Basire, William Skelton and James Heath. Excluding eight illustrations of intestinal worms where the provenance of the specimens is uncertain, a total of 98 specimens from William Hunter's collection were illustrated in 104 figures. Eight of the specimens were calculi impossible to identify specifically. Excluding worms and calculi, 72 of William Hunter's specimens illustrated by Baillie are extant in the Hunterian Collection at the University of Glasgow. All but one of the 20 specimens illustrated that had belonged to John Hunter were identified in the on‐line catalog of the Royal College of Surgeons of England. Baillie's own collection was destroyed when the Royal College of Surgeons of England was bombed in 1941. Baillie is credited with being the first to produce an illustrated systematic textbook of morbid anatomy and probably the first to illustrate emphysema and transposition of the great vessels. His book, however, was not comprehensive. It did not cover a number of topics such as muscles and bones and there is little coverage of the nervous system. Baillie's book, however, was an original concept as an atlas of morbid anatomy and showed his deep insight into pathology. Clin. Anat. 31:622–631, 2018. © 2017 Wiley Periodicals, Inc.
Synthesis, Optical Properties, and DNA Interaction of New Diquats Based on Triazolopyridines and Triazoloquinolines
Authors: Llabres‐Campaner Pedro J. , Guijarro Lluís , Giarratano Claudia , Ballesteros‐Garrido Rafael , Zaragozá Ramón J. , Aurell M. José , García‐España Enrique , Ballesteros Rafael , Abarca Belén 
Published: August 2017

AbstractNew diquat derivatives based on [1,2,3]triazolo[1,5‐a]pyridine and [1,2,3]triazolo[1,5‐a]quinoline have been synthesized in excellent yields. To evaluate the effect of the alkyl bridge length, ethane and propane dibromo alkane substrates were used for their synthesis. Theoretical calculations predicted a very small energetic barrier between the two possible enantiomers P (Ra) and M (Sa), which makes them very difficult to resolve. Thermal denaturation studies, UV/Visible spectroscopy, and fluorescence titrations with ct‐DNA evidenced the intercalation of the quinoline derivatives in DNA.
Octadentate Picolinic Acid‐Based Bispidine Ligand for Radiometal Ions
Authors: Comba Peter , Jermilova Una , Orvig Chris , Patrick Brian O. , Ramogida Caterina F. , Rück Katharina , Schneider Christina , Starke Miriam 
Published: August 2017

AbstractThe synthesis of the octadentate bispidine ligand bearing two picolinic acid pendant arms (H2bispa2), and its coordination chemistry with radionuclides relevant for nuclear medicine, namely indium(III) (111In), lutetium(III) (177Lu), and lanthanum(III) (as surrogate for 225Ac), are reported. The non‐radioactive metal complexes of the N6O2‐type bispa ligand were characterized by 1H and 13C NMR spectroscopy, elemental analysis, mass spectrometry and single‐crystal X‐ray analysis. Experimental structural data, computational analysis, complex stabilities determined by potentiometric titration, and “radiostabilities” determined by competition studies in the presence of human serum reveal complex stabilities of H2bispa2 comparable to those of the macrocyclic “gold standard” DOTA. After an incubation time of 1 day, 86 and 87 % of [177Lu(bispa2)]+ and [177Lu(DOTA)]−, respectively, remain intact. Importantly, unlike DOTA, H2bispa2 is radiolabeled quantitatively with 111InIII and 225AcIII under ambient conditions, which is an essential aspect when working with heat‐sensitive antibodies as targeting vectors. In the case of 111InIII, room temperature radiolabeling of H2bispa2 yields molar activities as high as 70 MBq nmol−1 within 10 minutes. These are promising results for radiopharmaceutical applications of H2bispa2.
Rhenium‐Loaded TiO2: A Highly Versatile and Chemoselective Catalyst for the Hydrogenation of Carboxylic Acid Derivatives and the N‐Methylation of Amines Using H2 and CO2
Authors: Toyao Takashi , Siddiki S. M. A. H. , Morita Yoshitsugu , Kamachi Takashi , Touchy Abeda S. , Onodera Wataru , Kon Kenichi , Furukawa Shinya , Ariga Hiroko , Asakura Kiyotaka , Yoshizawa Kazunari , Shimizu Ken‐ichi 
Published: August 2017

AbstractHerein, we report a heterogeneous TiO2‐supported Re catalyst (Re/TiO2) that promotes various selective hydrogenation reactions, which includes the hydrogenation of esters to alcohols, the hydrogenation of amides to amines, and the N‐methylation of amines, by using H2 and CO2. Initially, Re/TiO2 was evaluated in the context of the selective hydrogenation of 3‐phenylpropionic acid methyl ester to afford 3‐phenylpropanol (p
=5 MPa, T=180 °C), which revealed a superior performance over other catalysts that we tested in this study. In contrast to other typical heterogeneous catalysts, hydrogenation reactions with Re/TiO2 did not produce dearomatized byproducts. DFT studies suggested that the high selectivity for the formation of alcohols in favor of the hydrogenation of aromatic rings is ascribed to the higher affinity of Re towards the COOCH3 group than to the benzene ring. Moreover, Re/TiO2 showed a wide substrate scope for the hydrogenation reaction (19 examples). Subsequently, this Re/TiO2 catalyst was applied to the hydrogenation of amides, the N‐methylation of amines, and the N‐alkylation of amines with carboxylic acids or esters.