bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of One-Week Spinach and NBS Superfood Supplementation on Interleukin-6, Superoxide Dismutase, and Malondialdehyde Levels after Repeated Bouts of Wingate Test in Trained Men
Authors: shirinbayan mohammadmehdi , Azizi Mohammad , Amiri Ehsan 
Published: October 2024

Abstract

Background: Consuming nutritional supplements for improving athletic performance has always been considered an ergogenic aid. However, there is limited information on the efficacy of this strategy for enhancing antioxidant capacity in response to strenuous exercise with repeated nature. Therefore, this study investigated the effect of one week of spinach and NBS superfood supplementation on superoxide dismutase, malondialdehyde, and interleukin-6 in response to repeated bouts of Wingate test.
Methods: Fifteen trained men voluntarily participated in this within-subject and counter-balanced study. Participants were exposed to three different conditions including 1) seven days of raw spinach supplementation (daily dose of 70 g); 2) seven days of NBS superfood supplementation (daily dose of 10 g); and 3) the control condition. One day after the supplementation period, participants came to the lab and performed 3 bouts of 30-second Wingate test with 4-minute rest intervals. Before the supplementation and 24 hours after performing the Wingate, test blood samples were taken in each condition to measure serum levels of superoxide dismutase, malondialdehyde, and interleukin-6. One week of wash-out was applied between the conditions. Two-way repeated measures ANOVA were used for statistical analysis.
Results: The results showed that at post-test measurement the serum level of interleukin-6 was significantly lower under the spinach and superfood conditions (p=0.001, p=0.003, respectively) compared to the control. The serum level of superoxide dismutase under the spinach (p=0.035)and superfood (p=0.01) conditions was significantly higher compared to the control at post-test measurement. Also, at post-test measurement, the serum level of malondialdehyde was significantly lower under the spinach (p=0.001)and superfood (p=0.017) conditions compared to the control.
Conclusion:According to the results of the present study, it seems that seven days’ supplementation of either raw spinach or NBS superfood could positively affect the inflammatory responses to repeated anaerobic all-out activities. Therefore, these supplementation strategies might be considered ergogenic aids and used by athletes before participating in repeated strenuous activities.
Coping after breast cancer (CABC-trial): Testing two digital stress-management interventions in a randomized controlled trial at 6 months
Authors: Svendsen Karianne , Nes Lise Solberg , Leithe Sigrid , Meland Anders , Gjelsvik Ylva M. , Børøsund Elin , Larsson Ine M. , Myklebust Tor Åge , Balto Aina , Rygg Christine M. , Kiserud Cecilie E. , Antoni Michael H. , Chalder Trudie , Mjaaland Ingvil , Carlson Linda E. , Eriksen Hege R. , Ursin Giske 
Published: October 2024

Abstract

Purpose
The digital stress-management intervention StressProffen has been shown to be associated with improved well-being and quality of life for cancer survivors. In the Coping After Breast Cancer (CABC) trial, effects of 6 months access to modified versions of StressProffen, delivered through a digital download-only model, were examined.
Methods
Women with breast cancer were invited to participate in the trial 6–9 months following diagnosis. Eligible participants were randomized to either: 1) digital cognitive behavioral therapy stress-management intervention (CBI), n = 140, 2) digital mindfulness-based stress-management intervention (MBI), n = 143, or 3) usual-care (control group), n = 147. Primary outcome was change in perceived stress level (PSS-10), while secondary outcomes included changes in health-related quality of life (HRQoL), anxiety and depression, fatigue, mindfulness, sleep and coping.
Results
Perceived stress level at baseline was low for all groups. No statistically significant mean differences (MD) were detected between either of the intervention groups and the control group from baseline to 6-month follow-up for perceived stress level (MBI: MD -0.28 [95%CI: -1.75, 1.19], CBI: MD -0.42 [95%CI: -1.89, 1.06]), nor for the majority of the secondary outcomes.
Conclusion
After 6 months of access, the CBI and MBI stress-management interventions did not yield significantly improved outcomes for women with breast cancer compared with usual-care controls. Further explorations of which delivery models may optimize use and effect, best timing for delivery, and individual preferences, are needed.
ClinicalTrials.gov identifier NCT04480203.
Cardiac damage in a dog with natural acute infection by Trypanosoma cruzi III in an endemic area in the state of Rio Grande do Norte, Brazil
Authors: Araújo-Neto Vicente Toscano , Barbosa-Silva Andressa Noronha , Batista Lucas Abrantes , Mendes Rodrigo Souza , Negreiros Christiane Carlos Araújo , Fidellis Barbara Araújo , Sampaio George Harisson Felinto , Brito Carlos Ramon Nascimento , Guedes Paulo Marcos Matta , Galvão Lúcia Maria Cunha , Câmara Antonia Claudia Jácome 
Published: October 2024

Abstract

Background
Dogs are the main domestic reservoir of Trypanosoma cruzi and they are considered sentinels for new infection cases in humans. These animals are well-established infection models, but little is known about the natural development of the disease, especially in the acute phase. Dogs and triatomines are infected in the same environment with wide distribution of discrete typing units (DTUs) I, II e III in triatomines in several municipalities in the state of Rio Grande do Norte. This study describes clinical, hematological, biochemical, cardiological and parasitological aspects of a dog in the acute phase of T. cruzi infection and characterizes the isolate obtained by biological, molecular and phylogenetic methods.
Results
An apparently asymptomatic young animal showed a prolonged period of patent parasitemia, normocytic and hypochromic anemia. In addition, cardiac damage in this animal was observed by high concentration of biomarkers such as troponin I, NT-ProBN and doppler echocardiography examination with qualitative segmental hypokinesia. The isolated parasite was genotyped as TcIII using three molecular markers and phylogenetic analysis, initially described in a wild environment, this DTU is now present in the peridomicile.
Conclusions
The cardiac alterations detected in Canis familiaris with natural infection by T. cruzi contribute to expanding knowledge of the disease in these animals and the epidemiological scenario in an area where Triatoma brasiliensis is the main vector.
Association of Serum Chloride Levels with all-cause mortality among Patients in Surgical Intensive Care Unit: A Retrospective Analysis of the MIMIC-IV Database
Authors: Ma Quan , Tian Wei , Wang Kaifeng , Xu Bin , Lou Tianyu 
Published: October 2024

Abstract

This study aims to explore the correlation between serum chloride levels and all-cause mortality among patients in the Surgical Intensive Care Unit (SICU).A retrospective cohort study was conducted using data extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, focusing on patients admitted to surgical/trauma ICUs. Data included demographic information, laboratory results, medical history, vital signs, and prognosis-related variables. Patients were categorized into four groups based on serum chloride levels. Outcome measures included 30-day, 90-day, and 180-day mortality rates post-ICU admission. Kaplan–Meier survival analysis curves, Cox proportional hazards regression analysis, and Restricted Cubic Spline (RCS) models were used to analyze the relationship between serum chloride levels and clinical outcomes.A total of 10,996 patients were included in the study. The 30-day mortality rate was 12.78%, the 90-day mortality rate was 17.14%, and the 180-day mortality rate was 20.32%. Kaplan-Meier survival analysis demonstrated significant differences in survival rates among different serum chloride level groups during the 30-day, 90-day, and 180-day follow-up periods (p < 0.001). Multivariate Cox regression analysis results indicated that elevated serum chloride levels were significantly associated with decreased all-cause mortality rates at 30-days (adjusted hazard ratio [aHR]: 0.96; 95% confidence interval [CI]: 0.94–0.98; P < 0.001), 90-days (aHR: 0.97; 95% CI: 0.96–0.98; P < 0.001), and 180-days (aHR: 0.97; 95% CI: 0.96–0.98; P < 0.001). Moreover, compared with the first quartile of serum chloride levels, the risk of death was significantly lower in the fourth quartile (30-days aHR = 0.65, 90-days aHR = 0.71, 180-days aHR = 0.69, P < 0.001).RCS curves showed an L-shaped relationship between serum chloride levels and all-cause mortality risk for SICU patients at 30-days, 90-days, and 180-days. Although the magnitude of reduction diminished when levels reached 104 mmol/L, an increase in serum chloride levels was associated with a decreased risk of mortality.This study demonstrates a significant nonlinear relationship between serum chloride levels and all-cause mortality rates among SICU patients. This finding contributes to a more precise monitoring of chloride levels in SICU patients.
Urinary phytoestrogens were associated with reduced sensitivity to thyroid hormone in NHANES 2007-1010: A large cross-sectional study
Authors: Li Zongbao , Hu Fan , Yu Han , Yao Yao , Lu Yanhui 
Published: October 2024

Abstract

Background
Estrogen and thyroid hormone interact extensively in vivo, but the relationship between phytoestrogens and thyroid function and thyroid hormone sensitivity remains unclear.
Methods
Using 2007–2010 NHANES data of United States, we analysed the association of 6 types of urinary phytoestrogens with thyroid function and thyroid hormone sensitivity using a multivariate linear regression model.
Results
A total of 2,521 participants were included in the final analysis. After adjustment for multiple factors, we found that urinary phytoestrogens were associated with thyroid function and thyroid hormone sensitivity, and the associations were sex and type specific. For thyroid function: Phytoestrogens were negatively associated with FT4 and TT4 in overall analysis. After sex stratification, Equol, Enterodiol and TT4 were negatively associated in men. In women, Daidzein, O-Desmethylangolensin (O-DMA) and Genistein were positively associated with FT4, while Enterodiol was negatively associated with FT4. In addition, Enterolactone was negatively associated with TT4. For thyroid hormone sensitivity: Phytoestrogens were associated with Thyroid feedback quantile-based index (TFQI) in overall analysis. After sex stratification, Genistein was positively associated with FT3/FT4 ratio and Enterolactone was positively associated with TFQI in men. In women, Daidzein and O-DMA were negatively associated with FT3/FT4 ratio and positively associated with TFQI.
Conclusion
Urinary phytoestrogens were associated with FT4 and TT4 levels and may adversely affect the central thyroid hormone sensitivity. Given the risk of hypothyroidism and SCH associated with reduced thyroid hormone sensitivity, more health monitoring of people with high phytoestrogens intake is warranted.
Understanding the Role of Social Support in the Adherence to Hypertension Treatment in Cambodia
Authors: Chham Savina , Buffel Veerle , Ir Por , Ku Grace Marie , Chhim Srean , Damme Wim Van , Olmen Josefien Van , Wouters Edwin 
Published: October 2024

Abstract

Background
The prevalence of hypertension (HTN) in Cambodia was high (35.2%) in 2020 and only one-third achieved well-control. Effective HTN management strategies are needed but with focus on some key potential factors related to the poor adherence to treatment. Social support, especially from family members, is considered as a potential factor determining treatment adherence; however, evidence remains inconsistent with limited research conducted in Asia. Therefore, we assessed the role of social support on HTN treatment adherence in Cambodia to get a better understanding of the role of social support from family members in HTN management.
Methods
We performed a population-based survey among individuals aged ≥ 40 years and included 948 patients who were in-treatment in this study. Further key information was collected on adherence using the Medication Adherence Self-Report Scale (MARS-5) and family social support with eight-item modified Medical Outcomes Study Social Support (mMOS-SS) scale. Descriptive statistics were used to present the basic characteristics of the respondents. Chi-square test was used for the bivariate analysis of factors for treatment adherence. Multiple logistic regression was used to assess the association between family social support and HTN treatment adherence while controlling for some potential covariates.
Results
Among the 948 study participants, 43.5% reported non-adherence and 56.5% reported adherence to HTN treatment. For family social support, 19.7% reported poor level, 31.3% reported fair level, and 49.9% reported good level of support. Of those with adherence to HTN treatment, 29.2% had fair level of family social support, and 54.1% had good level of family social support. Unadjusted odd ratios (OR) from the univariate analysis showed a significant association between HTN treatment adherence and level of social support (P = 0.001). After controlling for covariates, having a good level of family social support increased the rate of adherence to HTN treatment by two-fold (AOR = 2.16, 95%CI = 1.49–3.14) compared to poor level.
Conclusions
The role of social support from family members was very positive in enhancing treatment adherence among patients with HTN in Cambodia. Potential strategic interventions should include focus on establishing an intervention involving family members to provide support for HTN treatment.
Predictors of distant metastasis or local recurrent after radiotherapy in patients with cervical cancer
Authors: Wu Chufan , Lv Xiaojuan , Lou Hanmei , Zhang Xiaojing , Wang Fangfang 
Published: October 2024

Abstract

Objective
To evaluated risk factors for survival, recurrence and metastasis in patients with FIGO stage IA-IVA cervical cancer who underwent radical radiotherapy (RT) or concurrent chemoradiotherapy (CCRT).
Methods
We performed a retrospective analysis of 1288 cervical cancer patients. Kaplan–Meier curves, Cox regression models, and log-rank tests were used for statistical analysis.
Results
The 5-year overall survival rate for patients with stage I-II and stage III-IVA are 81.1% and 70.4%. In multivariable analysis, pathological type, 2009 FIGO stage, pre-treatment SCC-Ag level, pre-brachytherapy tumor size, and CCRT are independent influencing factors for patient OS. Non-squamous cell carcinoma patients were more prone to distant metastasis than squamous cell carcinoma patients, with no significant correlation observed in local recurrence patients. In patients with squamous cell carcinoma, multivariable analysis showed that SCC value > 11.75 at diagnosis was an independent predictor of distant metastasis and local recurrence (P = 0.001 and P = 0.038, respectively). Lymph node metastasis was an independent risk factor for distant metastasis. Age, treatment time of RT, CCRT, and pre-treatment Hb classification showed no significant correlation with cervical cancer distant metastasis and local recurrence.
Conclusions
Non-squamous cell carcinoma patients may have a worse prognosis than squamous cell carcinoma patients. In patients with squamous cell carcinoma, SCC value at diagnosis, and lymph node metastasis are independent influencing factors for distant metastasis, while SCC value at diagnosis is an independent influencing factor for local recurrence.
Initial application of fluorescence imaging for intraoperative localization of small neuroendocrine tumors in the pancreas: case report and review of the literature
Authors: Xi Shihang , Wang Xu , Zheng Xingyuan , Jiang Bin , Shen Zhengchao , Wang Guannan , Jiang Yaqi , Fang Xiaosan , Qian Daohai , Muhammad Danish Irshad , Wang Xiaoming 
Published: October 2024

Abstract

Objective
A preliminary investigation into the efficacy and safety of fluorescence imaging for intraoperative localization of small neuroendocrine tumors in the pancreas.
Methods
Indocyanine green fluorescence imaging technology was employed during the surgical procedure. The administration of indocyanine green was executed as follows: 25 mg of the dye was dissolved in 10 ml of sterilized water for injection. Subsequently, 1 ml of the solution was swiftly administered through a peripheral vein during laparoscopic tumor exploration. Approximately 1 minute later, the tumor exhibited a distinct green fluorescence, indicating successful staining. Guided by real-time fluorescence imaging, laparoscopic local excision of the pancreatic tumor was performed. Severe complications were observed following the operation.Additionally, the surgical margins, tumor grade, and other pathological details were documented.
RESULTS
Five patients, who underwent laparoscopic local resection of pancreatic tumors under fluorescence guidance, exhibited excellent fluorescence imaging and distinct lesion boundaries. Following surgery, only biochemical fistulae were detected. The pathology reports of four patients indicated pancreatic neuroendocrine tumors of grade G1 with negative margins, while one patient's pathology suggested pancreatic neuroendocrine cell hyperplasia.
CONCLUSION
Fluorescence imaging technology safely aids in the intraoperative localization of small pancreatic neuroendocrine tumors.
Lumbar intervertebral endplate autograft fusion on patients with lumbar spinal instability and lumbar spondylolisthesis
Authors: Zhang Shun , Zhang Chuanlin 
Published: October 2024

Abstract

Background
Lumbar interbody fusion with standalone local bone grafts sufficed for single-level low-grade spondylolisthesis via the open posterior approach. This study aimed to assess the impact of lumbar intervertebral endplate autograft fusion on middle-aged and elderly adults with lumbar spinal instability and spondylolisthesis.
Methods
32 patients with these conditions were included in the study at a hospital between June 2018 and January 2023, undergoing either lumbar intervertebral endplate autograft fusion or intervertebral graft fusion.
Results
The two groups showed no significant differences in postoperative measures except for the JOA low back pain score and SF-36 score, which were better in the endplate autograft fusion group. The endplate fusion ratio was significantly higher in the autograft fusion group.
Conclusions
Lumbar intervertebral endplate autograft fusion may be a promising approach for patients with lumbar spine instability and low-grade spondylolisthesis, potentially leading to a higher endplate fusion ratio compared to conventional methods.
Does the number of abnormal values in the oral glucose tolerance test impact pregnancy outcomes?
Authors: Gluska Hadar , Yagur Yael , Margalit Shiri , Sokolik Karolin , Pardo Ella , Shechter-Maor Gil , Biron-Shental Tal , Kovo Michal , Weitzner Omer 
Published: October 2024

Abstract

Background: Gestational diabetes mellitus (GDM) affects over 10% of pregnancies worldwide, leading to various maternal and neonatal complications. The American College of Obstetricians and Gynecologists (ACOG) recommends a two-step diagnostic approach using the Glucose Challenge Test (GCT) and the oral glucose tolerance test (OGTT), which can yield between 0 to 4 abnormal values (AbVs).The primary objective of this study was to evaluate the association between the number of AbVs in the oral glucose tolerance test (OGTT) and the risk of GDMA2, which requires pharmacological intervention for glycemic control. Secondary outcomes included assessing the relationship between the number of AbVs and adverse maternal and neonatal outcomes, considering its impact on the course of pregnancy, delivery, maternal health, and neonatal outcomes.Methods This retrospective cohort study included all pregnant women who underwent OGTT between the years 2015 and 2022, and diagnosed with GDM, at our department. The study cohort was divided into four groups based on the number of AbVs in the OGTT: one AbV, two AbVs, three AbVs and four AbVs group. Maternal characteristics and pregnancy outcomes were compared between these groups.Results A total of 1821 women diagnosed with GDM following were included in the analysis. The distribution of abnormal OGTT AbVs was as follows: one AbV (36.95%), two AbVs (43.71%), three AbVs (16.09%), and four AbVs (3.24%). Presence of GDMA2 varied significantly among groups (p < 0.001), with higher occurrence correlating with increased AbVs. Maternal outcomes differed in induction of labor (p < 0.001), episiotomy (p = 0.006), and maternal composite outcomes (p = 0.011). Neonatal outcomes showed differences in gestational age at delivery (p = 0.007) and Apgar score < 7 (p = 0.021). Logistic regression adjusted for confounders revealed that the number of AbVs (aOR 1.2, 95% CI 1.01–1.42) and maternal BMI (aOR 1.07, 95% CI 1.05–1.1) were significantly associated with GDMA2.Conclusions An elevated number AbVs indicates challenges in glycemic control through dietary measures alone, necessitating potential medical interventions. An increased occurrence of AbVs in OGTT correlates with heightened probabilities of GDMA2, labor induction, episiotomy, and neonatal Apgar scores below 7. From the study results we can infer that OGTT serves not only as a diagnostic tool for GDM but also enables healthcare practitioners to enhance their awareness of potential adverse outcomes for both the mother and neonate through meticulous analysis of abnormal values.
Gender-Specific Association Between a Lipid Composite Index and Asthma among US Adults: Insights from a Population-Based Study
Authors: Ying Bufan , Liu Xiaoxin , Yang Chengming , Xu Jinfang , Li Ningxu 
Published: October 2024

Abstract

Background
Abnormalities in lipid metabolism are common among adult asthmatics. However, the precise directionality linking asthma to blood lipid levels remains controversial. Our study aimed to evaluate the association between the Non-HDL to HDL Ratio (NHHR), a lipid composite index, and asthma prevalence among the adult population in the United States.
Methods
Utilizing adult participants’ data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2009 to 2018, the study employed a multivariate logistic regression model, adjusting for covariates, to establish the relationship between NHHR levels and the prevalence of asthma. Furthermore, smoothing curve fitting and subgroup analyses were conducted to investigate the robustness of this association.
Results
This study included 26,023 adult individuals (mean age = 49.63 ± 17.66). In the fully adjusted model, a significant inverse correlation was observed between log-transformed NHHR values and asthma prevalence (OR = 0.85, 95% CI: 0.79–0.93). Subgroup analysis revealed that gender served as a modulator, altering the association between NHHR levels and asthma prevalence. A more pronounced negative correlation between NHHR and asthma prevalence was noted among male participants [(Male: OR = 0.78, 95% CI: 0.69–0.88) vs. (Female: OR = 0.92, 95% CI: 0.83–1.03), P for interaction = 0.0313]. The relationship between NHHR and the prevalence of asthma in females exhibited a U-shaped pattern, with the inflection point at an NHHR value of 3.77.
Conclusions
Among the adult population in the US, an inverse correlation exists between NHHR levels and asthma prevalence, which is influenced by gender. NHHR measurement may be a potential tool for early identification and prediction of adult-onset asthma in specific populations.