bluuebunny/crossref_metadata_2025_split huggingface dataset:
A MULTIDISCIPLINARY APPROACH TO PERFORMING ENDOVASCULAR OPERATIONS AND ECONOMICAL FOOT AMPUTAIONS AGAINST THE BACKGROUND OF CHRONIC THREATENING ISCHEMIA OF THE LOWER EXTREMITIES (CLTI)
Authors: GOSHCHYNSKY V. B. , MIGENKO B. O. , SVISTUN R. V. 
Published: September 2024

The aim of the work: to determine the effectiveness of a multidisciplinary approach to the treatment of chronic threatening ischemia of the lower extremities associated with necrotic changes in the area of the foot.
Мaterials and Methods. The results of the use of endovascular operations in 39 patients with CLTI IV class were analyzed according to the Fontaine classification (category 6 according to the Rutherford classification), with open wounds after amputation of a part of the foot due to dry gangrene and PRP and PRF therapy using the PRGF®-ENDORET® technology, according to the examination and conclusions of the multidisciplinary team. The control group consisted of 41 patients with a similar pathology and stage of the necrotic process, in the treatment of which no relevant specialists were involved, and the treatment of open wounds after amputation of a part of the foot due to dry gangrene was carried out according to traditional methods. The average age of the patients was 56.7±9.3 years, all men. A multidisciplinary team consisting of vascular surgeons, ultrasound specialists and angioradiologists, an interventional physician, an orthopedic surgeon, and functional diagnosticians was created for the specific treatment tactics of the above-mentioned patients. In order to determine the indications for performing small amputations on the foot, we performed a comprehensive assessment of the limb's blood supply after endovascular operations and the use of platelet-rich plasma.
Results and Discussion.The use of endovascular operations in combination with PRP and PRF has a positive effect on the blood supply in the ischemic limb. This is evidenced by: improvement of indicators of microcirculation, speed of blood flow, increase of local skin temperature on the foot, indicators of the Ankle Brachial Index. As our studies have shown, the activity of the tyrosine kinase system, as well as the peculiarities of the cytokine relationship, which is a reflection of the processes of alteration and proliferation in the wound, can be an objective criterion for skin autotransplantation on the wound surface. After consultation with an orthopedist, we performed amputation of the foot: according to Garangeau – in 10 patients, according to Chopar – in 51 cases, according to Lisfranc or Lisfranc-Haye in 19 patients. Due to the lack of skin flaps, the wounds were treated by an open method followed by autodermoplasty, except for 39 patients (after endovascular surgery and PRP therapy), who were stimulated on the 5-6th day after foot amputation with the help of a plasma membrane (PRGF supernatant) ®-Endoret®), enriched with a growth factor, which covered the entire area of the wound surface.
ВПЛИВ ПОШКОДЖЕННЯ ШКІРИ НА ДІУРЕЗ ТА ФІЛЬТРАЦІЙНУ ФУНКЦІЮ НИРОК ЗА УМОВ ПОЄДНАНОЇ ТРАВМИ ТА ЕФЕКТИВНІСТЬ PRP-ТЕРАПІЇ
Authors: ПРИМАЧЕНКО Т. В. , ГУДИМА А. А. 
Published: September 2024

Мета роботи: зʼясувати вплив пошкодження шкіри на діурез та фільтраційну функцію нирок за умов поєднаної травми та оцінити ефективність PRP-терапії в умовах досліджуваної патології.
Матеріали і методи. В експериментах на 96 статевозрілих білих щурах-самцях лінії Вістар масою 200–220 г під тіопентало-натрієвим наркозом моделювали скелетну травму (дослідна група 1), поєднану травму, яка включала скелетну травму, ускладнену механічним пошкодженням шкіри (дослідна група 2). У дослідній групі 3 щурам з поєднаною травмою проводили PRP-терапію: алогенну плазму, збагачену тромбоцитами, вводили внутрішньодермально по 0,1 мл в ділянку рани шкіри. Через 3, 7, 14, 21 та 28 діб після моделювання травм у щурів визначали функціональний стан нирок методом водного навантаження: встановлювали діурез та швидкість клубочкової фільтрації.
Результати. Модельована скелетна травма, яка включає перелом стегнової кістки та гостру крововтрату, викликає сповільнення діурезу та швидкості клубочкової фільтрації. Додаткове пошкодження шкіри сприяє поглибленню порушень. Показники стають статистично вірогідно меншими, порівняно зі щурами з самою скелетною травмою. За умов поєднаної травми використання PRP-терапії у групі щурів викликає поступове зростання діурезу та швидкості клубочкової фільтрації з 7 до 28 діб експерименту. Порівняно з травмованими щурами без корекції показники стають статистично вірогідно більшими за величиною діурезу починаючи з 21 доби експерименту, за величиною швидкості клубочкової фільтрації – через 28 діб. Отже, на тлі PRP-терапії в період пізніх проявів травматичної хвороби настає покращення фільтраційної функції нирок, що вказує на перспективність методу для зменшення системного патогенного впливу на організм і вимагає подальшого поглибленого вивчення.
ПОВТОРНІ ОПЕРАЦІЇ В АБДОМІНАЛЬНІЙ ХІРУРГІЇ
Authors: КОРОЛЬ Я. А. , ШЕРЕМЕТА С. О. , КРУК О. С. , КОРОЛЬ Р. Я. 
Published: September 2024

Мета: вивчення причин, показань та результатів виконання релапаротомій після хірургічних операцій на органах черевної порожнини залежно від нозології і характеру першого операційного втручання.
Матеріал і методи. В ході дослідження проаналізовано 38 карт стаціонарних хворих, яких проліковано в клініці хірургії, пластичної хірургії та ендоскопії ФПДО ЛНМУ імені Данила Галицького (база – відділення № 2 центру хірургії та онкології КНП 1 ТМО м. Львова) за період з січня 2021 до грудня 2023 рр. Переважали жінки (21 хвора – 55,3 %) віком від 24 до 85 років (середній вік – (61,8±16,32) років). Основною патологією, яка у післяопераційному періоді потребувала виконання релапаротомій, був колоректальний рак (8 пацієнтів – 21,1 %). Тяжкість передопераційного стану хворого за ASA становила I і II ступенів (по 12 пацієнтів – 31,6 %), III ступеня – 10 (26,3 %) та IV – 4 (10,5 %). Ступені тяжкості ускладнень за класифікацією Clavien–Dindo були здебільшого IIIb – 17 пацієнтів (44,7 %) та IVb – 18 (47,4 %).
Результати. Усі релапаротомії здійснено під ендотрахеальним наркозом. Переважній більшості пацієнтів (36 – 94,7 %) проведено вимушені повторні втручання, причому термін їх виконання здебільшого становив понад 10 діб після первинного операційного втручання. Повторні абдомінальні втручання були від найпростіших (дренування черевної порожнини), до таких, які складають певну технічну складність (правобічна геміколектомія). Ускладнення у ранньому післяопераційному періоді після релапаротомій виникло в 16 (42,1 %) пацієнтів, причому в 11 (28,9 %) для їх ліквідації довелось здійснювати повторні втручання, зокрема, в 7 (18,4 %) – один раз та багаторазово – у решти. Серед ускладнень здебільшого було прогресування сепсису. Помер 21 пацієнт; післяопераційна летальність становила 55,3 %. Основною причиною летального наслідку була поліорганна недостатність (18 хворих).
Mori Arinori: Japan’s Diplomat in Washington, D.C.
Authors: Van Sant John E. 
Published: September 2024

Abstract
This article briefly examines the life of Mori Arinori, who in 1871 became Japan’s first resident diplomat in Washington, D.C., with the primary assignment of making preparations for the upcoming Iwakura Mission. Mori’s pedigree of being from a samurai family from Satsuma domain and his unusual background of having already lived in Britain and the United States led senior officials of the new Meiji Imperial government to name Mori to the all-important position of being Japan’s top representative to the United States despite his youth – he was only 23 years old at the time of his appointment. Notwithstanding his occasional impatience with Japanese traditions and the more reserved senior officials of the Iwakura Embassy, Mori’s connections in Washington D.C., his understanding of American society, and his skill at the English language significantly contributed to the institutional, cultural, and economic information that members of the Japanese delegation gathered. Mori’s post-Washington career as an intellectual, diplomat, and top education official in Japan in the late 1870s and 1880s also contributed to his country’s progression from the collapse of the Tokugawa Shogunate to the cusp of Japan’s international recognition as a major power in a world being transformed by industrialization and imperialism.
Effect of Y on Oxidation Behavior of Directionally Solidified Ni-Based Single-Crystal Superalloy
Authors: Zhao Zihan , Guan Kai , Cui Renjie , Qin Jianchao , Huang Zhaohui 
Published: September 2024

AbstractThe effect of yttrium (Y) addition on the oxidation behavior of a Ni-based directionally solidified single-crystal superalloy is investigated in this study. Isothermal oxidation tests for samples with different levels of Y addition are conducted at 1100 °C in air. The Y content of the samples is determined by the actual pickup amount obtained from an Inductively Coupled Plasma-Atomic Emission Spectrometry test. It is discovered that the addition of Y increases the oxide resistance by the scale of an adhesive double-layer oxide, which is composed of Al2O3 and spinel Ni(Cr,Al)2O4. With 70 ppm of Y addition, the oxidation mass gain decreases from 12.6 g/m2 for the alloy without Y addition to 5.3 g/m2, and the oxidation rate decreases significantly. In addition, the internal nitride disappears after Y doping because of an increase in oxidation scale adherence and a decrease in oxidation products. In this study, the alloy with 660 ppm Y addition demonstrates the best oxidation resistance.
The use of nanomaterials as drug delivery systems and anticancer agents in the treatment of triple-negative breast cancer: an updated review (year 2005 to date)
Authors: Ndongwe Tanaka , Zhou Angel-Alberta , Ganga Nelisa Paidamwoyo , Matawo Nyaradzo , Sibanda Unami , Chidziwa Tinotenda Vanessa , Witika Bwalya A. , Krause Rui W. M. , Matlou Gauta Gold , Siwe-Noundou Xavier 
Published: September 2024

AbstractTriple-negative breast cancer (TNBC) is characterised by the lack or low expression of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors. TNBC has a high recurrence rate, swiftly metastasizes, and has a high mortality rate. Subsequently, the increase in cases of TNBC has signaled the need for treatment strategies with improved drug delivery systems. New diagnostic approaches, chemical entities, formulations particular those in the nanometric range have emerged after extensive scientific research as alternative strategies for TNBC treatment. As compared to contemporary cancer therapy, nanoparticles offer peculiar tunable features namely small size, shape, electrical charge, magnetic and fluorescent properties. Specifically in targeted drug delivery, nanoparticles have been demonstrated to be highly efficient in encapsulating, functionalization, and conjugation. Presently, nanoparticles have ignited and transformed the approach in photodynamic therapy, bioimaging, use of theranostics and precision medicine delivery in breast cancer. Correspondingly, recent years have witnessed a drastic rise in literature pertaining to treatment of TNBC using nanomaterials. Subsequently, this manuscript aims to present a state-of-the-art of nanomaterials advance on TNBC treatment; the ubiquitous utility use of nanomaterials such as liposomes, dendrimers, solid lipid nanomaterials, gold nanomaterials and quantum dots as anticancer agents and drug delivery systems in TNBC.
The prognostic role of palliative gastrectomy in advanced gastric cancer: a systematic review and meta-analysis
Authors: Luo Desheng , Xu Hongtao , Jiang Chuan , Zheng Jingjing , Wu Dan , Tou Laizhen , Que Haifeng , Sun Zheng 
Published: September 2024

Abstract
Background
The effectiveness of palliative gastrectomy for advanced GC remains a topic of debate. This study sought to establish whether palliative gastrectomy has an impact on prolonging survival.

Methods
We carried out systematic searches in PubMed, Cochrane Library, Web of Science, and the EMBASE databases from database inception to July 2023 to gather studies that examined the connection between palliative gastrectomy and the prognosis of advanced GC. The study employed overall survival as the primary outcome, with the hazard ratio serving as the selected parameter to gauge the association. Subgroup analyses were performed to delve into potential differences within the included studies, categorizing them by study region and sample size in order to examine possible sources of heterogeneity. The stability of individual studies was assessed through sensitivity analysis. The analysis included 20 articles, encompassing a total of 23,061 patients.

Results
According to the meta-analysis results, patients who underwent palliative gastrectomy exhibited a noteworthy enhancement in overall survival (HR: 1.49; 95% CI: 1.12–1.99; P = 0.006) in comparison to those who did not receive this procedure. There was no association between the type of surgery and the length of hospital stay, as revealed by the analysis (HR = -0.02; 95% CI: -0.84–0.81; P = 0.970).

Conclusions
Based on this meta-analysis, patients with advanced gastric cancer who underwent palliative gastrectomy may experience an extended survival duration without a significant prolongation of their hospitalization.
ETDRS grading with CLARUS ultra-widefield images shows agreement with 7-fields colour fundus photography
Authors: Santos Ana Rita , Ghate Sejal , Lopes Marta , Rocha Ana Cláudia , Santos Torcato , Reste-Ferreira Débora , Manivannan Niranchana , Foote Katharina , Cunha-Vaz José 
Published: September 2024

Abstract
Background
To analyse and compare the grading of diabetic retinopathy (DR) severity level using standard 35° ETDRS 7-fields photography and CLARUS™ 500 ultra-widefield imaging system.

Methods
A cross-sectional analysis of retinal images of patients with type 2 diabetes (n = 160 eyes) was performed for this study. All patients underwent 7-fields colour fundus photography (CFP) at 35° on a standard Topcon TRC-50DX® camera, and ultra-widefield (UWF) imaging at 200° on a CLARUS™ 500 (ZEISS, Dublin, CA, USA) by an automatic montage of two 133° images (nasal and temporal). 35° 7-fields photographs were graded by two graders, according to the Early Treatment Diabetic Retinopathy Study (ETDRS). For CLARUS UWF images, a prototype 7-fields grid was applied using the CLARUS review software, and the same ETDRS grading procedures were performed inside that area only. Grading of DR severity level was compared between these two methods to evaluate the agreement between both imaging techniques.

Results
Images of 160 eyes from 83 diabetic patients were considered for analysis. According to the 35° ETDRS 7-fields images, 22 eyes were evaluated as DR severity level 10–20, 64 eyes were evaluated as DR level 35, 41 eyes level 43, 21 eyes level 47, 7 eyes level 53, and 5 eyes level 61. The same DR severity level was achieved with CLARUS 500 UWF images in 92 eyes (57%), showing a perfect agreement (k > 0.80) with the 7-fields 35° technique. Fifty-seven eyes (36%) showed a higher DR level with CLARUS UWF images, mostly due to a better visualization of haemorrhages and a higher detection rate of intraretinal microvascular abnormalities (IRMA). Only 11 eyes (7%) showed a lower severity level with the CLARUS UWF system, due to the presence of artifacts or media opacities that precluded the correct evaluation of DR lesions.

Conclusions
UWF CLARUS 500 device showed nearly perfect agreement with standard 35° 7-fields images in all ETDRS severity levels. Moreover, CLARUS images showed an increased ability to detect haemorrhages and IRMA helping with finer evaluation of lesions, thus demonstrating that a UWF photograph can be used to grade ETDRS severity level with a better visualization than the standard 7-fields images.

Trial registration
Approved by the AIBILI - Association for Innovation and Biomedical Research on Light and Image Ethics Committee for Health with number CEC/009/17- EYEMARKER.
Innovate! Accelerate! Evaluate! Harnessing the RE-AIM framework to examine the global dissemination of parenting resources during COVID-19 to more than 210 million people
Authors: Lachman Jamie M. , Nurova Nisso , Chetty Angelique Nicole , Fang Zuyi , Swartz Alison , Sherr Lorraine , Mebrahtu Helen , Mwaba Kasonde , Green Ohad , Awah Isang , Chen Yuanling , Vallance Inge , Cluver Lucie 
Published: September 2024

Abstract
Background
Parents were at the forefront of responding to the needs of children during the COVID-19 pandemic. This study used the RE-AIM framework to examine the Reach, Effectiveness, Adoption, Implementation, and Maintenance of a global inter-agency initiative that adapted evidence-based parenting programs to provide immediate support to parents.

Methods
Data were collected via short surveys sent via email, online surveys, and analysis of social media metrics and Google Analytics. Retrospective surveys with 1,303 parents and caregivers in 11 countries examined impacts of the resources on child maltreatment, positive relationship building, parenting efficacy, and parenting stress.

Results
The parenting resources were translated into over 135 languages and dialects; reached an estimated minimum 212.4 million people by June 2022; were adopted by 697 agencies, organizations, and individuals; and were included in 43 national government COVID-19 responses. Dissemination via social media had the highest reach (n = 144,202,170, 67.9%), followed by radio broadcasts (n = 32,298,525, 15.2%), text messages (n = 13,565,780, 6.4%), and caseworker phone calls or visits (n = 8,074,787, 3.8%). Retrospective surveys showed increased parental engagement and play, parenting self-efficacy, confidence in protecting children from sexual abuse, and capacity to cope with stress, as well as decreased physical and emotional abuse. Forty-four organizations who responded to follow-up surveys in April 2021 reported sustained use of the resources as part of existing services and other crisis responses.

Conclusion
This study highlights the importance of a) establishing an international collaboration to rapidly adapt and disseminate evidence-based content into easily accessible resources that are relevant to the needs of parents; b) creating open-source and agile delivery models that are responsive to local contexts and receptive to further adaptation; and c) using the best methods available to evaluate a rapidly deployed global emergency response in real-time. Further research is recommended to empirically establish the evidence of effectiveness and maintenance of these parenting innovations.
Adrenal tumours in patients with pathogenic APC mutations: a retrospective study
Authors: Lin Lyman , Beshay Victoria , Macrae Finlay 
Published: September 2024

Abstract
Background
Adrenal tumours are associated with familial adenomatous polyposis (FAP). In the literature, most studies use the clinical definition of FAP (more than 100 adenomatous polyps found in endoscopic studies). However, not all patients that meet clinical criteria for FAP carry pathogenic mutations in the adenomatous polyposis coli (APC) gene, as there is genetic heterogeneity responsible for FAP with the polyposis sometimes explained by genetic and environmental factors other than pathogenic APC mutations. Reciprocally, not all the patients with pathogenic APC variants will fulfil the classic criteria of FAP.

Objective
This study aims to investigate the characteristics of adrenal tumours in patients with pathogenic or likely pathogenic APC variants and explore the hormonal function of these patients.

Method
This is a retrospective cohort study. Patients with pathogenic or likely pathogenic APC variants were recruited and their radiological assessments were reviewed. Patient demographic data, APC variants, adrenal mass characteristics and hormonal testing results were collected.

Result
The prevalence of adrenal mass was 26.7% (24/90) among patients with pathogenic or likely pathogenic APC variants. Using the classic definition, the prevalence was 32.4% (22/68). Four patients had adrenal hormone testing, two of which had Conn’s syndrome and two had nonspecific subclinical results.

Conclusion
In our cohort, the prevalence of adrenal tumours among patients with pathogenic and likely pathogenic APC mutations is at least twice to three times higher than the general population prevalence reported from international population-based studies. The hormonal functions of patients with pathogenic APC variants and adrenal tumours can be investigated with routine testing in further research.
Add-on hemoperfusion in SARS-CoV-2-infected pregnant patients: a case series
Authors: Chiewroongroj Supattra , Naorungroj Thummaporn , Ratanarat Ranistha 
Published: September 2024

Abstract
Background
Pregnant women are more likely to have a higher severity of illness after being infected with coronavirus disease 2019 compared with the general population, particularly in the hyperinflammatory phase. However, immunomodulatory drugs are contraindicated and have been associated with an increased risk of fetal abnormalities. Therefore, we are reporting our experience with the use of HA330 hemoperfusion in combination with standard therapy in severe to critical coronavirus disease 2019 cases among pregnant patients.

Case presentation
From January 2020 to December 2021, four pregnant Thai women were treated with hemoperfusion using a cytokine adsorptive technique. The patients’ ages ranged from 21 to 36 years old, and their gestational ages at the time of admission ranged from 18 to 38 weeks. Two patients required intubation. Extracorporeal blood purification with an adsorptive cartridge (HA330®, Jafron, China) was applied as an adjunctive strategy to standard therapy approximately one week after the onset of symptoms, and most patients received three sessions of hemoperfusion. The baseline C-reactive protein level was greater than 80 mg/dL. The results showed that hemoperfusion could decrease the C-reactive protein level by approximately 80% and improve oxygenation. The newborns were delivered by Cesarean section without complications. Neither mortality nor serious adverse events related to hemoperfusion occurred.

Conclusion
This report may help ensure the use of the hemoperfusion strategy in pregnant patients during a cytokine storm. However, a larger cohort is needed to confirm its safety and efficacy.