bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRAINS IN VATS? DON'T BOTHER!
Authors: Baumann Peter 
Published: August 2017

ABSTRACTContemporary discussions of epistemological skepticism – the view that we do not and cannot know anything about the world around us – focus very much on a certain kind of skeptical argument involving a skeptical scenario (a situation familiar from Descartes' First Meditation). According to the argument, knowing some ordinary proposition about the world (one we usually take ourselves to know) requires knowing we are not in some such skeptical scenario SK; however, since we cannot know that we are not in SK we also cannot know any ordinary proposition. One of the most prominent skeptical scenarios is the brain-in-the-vat-scenario: An evil scientist has operated on an unsuspecting subject, removed the subject's brain and put it in a vat where it is kept functioning and is connected to some computer which feeds the brain the illusion that everything is “normal”. This paper looks at one aspect of this scenario after another – envatment, disembodiment, weird cognitive processes, lack of the right kind of epistemic standing, and systematic deception. The conclusion is that none of these aspects (in isolation or in combination) is of any relevance for a would-be skeptical argument; the brain-in-the-vat-scenario is irrelevant to and useless for skeptical purposes. Given that related scenarios (e.g., involving evil demons) share the defects of the brain-in-the-vat-scenario, the skeptic should not put any hopes on Cartesian topoi.
Prediction of RecurrentClostridium DifficileInfection Using Comprehensive Electronic Medical Records in an Integrated Healthcare Delivery System
Authors: Escobar Gabriel J. , Baker Jennifer M. , Kipnis Patricia , Greene John D. , Mast T. Christopher , Gupta Swati B. , Cossrow Nicole , Mehta Vinay , Liu Vincent , Dubberke Erik R. 
Published: August 2017

BACKGROUNDPredicting recurrentClostridium difficileinfection (rCDI) remains difficult. METHODS. We employed a retrospective cohort design. Granular electronic medical record (EMR) data had been collected from patients hospitalized at 21 Kaiser Permanente Northern California hospitals. The derivation dataset (2007–2013) included data from 9,386 patients who experienced incident CDI (iCDI) and 1,311 who experienced their first CDI recurrences (rCDI). The validation dataset (2014) included data from 1,865 patients who experienced incident CDI and 144 who experienced rCDI. Using multiple techniques, including machine learning, we evaluated more than 150 potential predictors. Our final analyses evaluated 3 models with varying degrees of complexity and 1 previously published model.RESULTSDespite having a large multicenter cohort and access to granular EMR data (eg, vital signs, and laboratory test results), none of the models discriminated well (c statistics, 0.591–0.605), had good calibration, or had good explanatory power.CONCLUSIONSOur ability to predict rCDI remains limited. Given currently available EMR technology, improvements in prediction will require incorporating new variables because currently available data elements lack adequate explanatory power.Infect Control Hosp Epidemiol2017;38:1196–1203
Boundary Element Calculation of Near-Boundary Solutions in 3D Generally Anisotropic Solids by the Self-Regularization Scheme
Authors: Shiah Y. C. , Chang L. D. 
Published: August 2017

AbstractThis research targets investigation of the internal elastic field near the boundaries of 3D anisotropic bodies by the boundary element method (BEM). This analysis appears to be most important, especially for the interest in the internal solutions near corners or crack tips, where structural failure is most likely to occur. Although the BEM is very efficient for analyzing the problem, nearly singular integration will arise when the internal point of interest stays near the boundary. The present work is to show how the self-regularized boundary integral equation (BIE) can be applied to the interior analysis for 3D generally anisotropic bodies. So far, to the authors' best knowledge, no implementation work has been reported in the literature for successfully treating the near boundary solutions in 3D generally anisotropic solids. In the end, a few benchmark examples are presented to demonstrate the veracity of the present approach for the interior BEM analysis of 3D anisotropic elasticity.
Temperature-dependent development ofHelicoverpa armigera(Hübner) (Lepidoptera: Noctuidae) and its larval parasitoid,Habrobracon hebetor(Say) (Hymenoptera: Braconidae): implications for species interactions
Authors: Noor-ul-Ane M. , Ali Mirhosseini M. , Crickmore N. , Saeed S. , Noor I. , Zalucki M.P. 
Published: August 2017

AbstractHabrobracon hebetor(Say) is a parasitoid of various Lepidoptera includingHelicoverpa armigera(Hübner), a key pest of different crops and vegetables. The development of bothH. armigeraandH. hebetorwere simultaneously evaluated against a wide range of constant temperatures (10, 15, 17.5, 20, 25, 27.5, 30, 35, 37.5 and 40 °C).Helicoverpa armigeracompleted its development from egg to adult within a temperature range of 17.5–37.5 °C andH. hebetorcompleted its life cycle from egg to adult within a temperature range of 15–40 °C. Based on the Ikemoto and Takai model the developmental threshold (To) and thermal constant (K) to complete the immature stages, ofH. armigerawere calculated as 11.6 °C and 513.6 DD, respectively, and 13 °C and 148 DD, respectively, forH. hebetor. Analytis/Briere-2 and Analytis/Briere-1 were adjudged the best non-linear models for prediction of phenology ofH. armigeraandH. hebetor, respectively and enabled estimation of the optimum (Topt) and maximum temperature (Tmax) for development with values of 34.8, 38.7, 36.3, and 43 °C for host and the parasitoid, respectively. Parasitisation byH. hebetorwas maximal at 25 °C but occurred even at 40 °C. This study suggests although high temperature is limiting to insects, our estimates of the upper thermal limits for both species are higher than previously estimated. Some biological control ofH. armigerabyH. hebetormay persist in tropical areas, even with increasing temperatures due to climate change.
REE partition among zircon, orthopyroxene, amphibole and garnet in a high-grade metabasic system
Authors: FORNELLI ANNAMARIA , LANGONE ANTONIO , MICHELETTI FRANCESCA , PICCARRETA GIUSEPPE 
Published: August 2017

AbstractA mafic amphibole-bearing granulite with porphyroblastic garnet was investigated to evaluate: (1) the rare earth element (REE) partition among garnet, zircon, orthopyroxene and amphibole during the metamorphic evolution; (2) the significance of the REE distribution along lobes and bights of reabsorbed garnet rim; and (3) REE distribution coefficient values (DREE) suggestive of chemical equilibrium, assuming garnet as a reference. The results have been compared with those deriving from an intermediate granulite containing porphyroblastic garnet, without amphibole. Porphyroblastic garnet from both samples is rimmed by a continuous corona formed during post-peak decompression characterized by REE-enriched lobes and REE-poor bights. The amphiboles from corona have various REE abundances, reflecting a different dissolution rate of original garnet rim. The initial slow rate of garnet dissolution caused high REE concentration in the new garnet rim due to intra-crystalline diffusion, leading to the formation of REE-poorer amphiboles in corona. Subsequently, under an increasing geothermal gradient and fluid-present conditions, the faster dissolution of garnet determined the formation of bights and the transfer of REEs towards the corona. The timing of garnet growth and its dissolution were checked by U–Pb zircon ages. The zircons dated from 339 Ma to 303 Ma in two rock types combined with the garnet domains (core, outer core, rim) show similar distribution of patterns relative to heavy rare earth elements for zircon and garnet (DHREEzrn/grt), suggesting chemical equilibrium. Zircons dated at c. 300 Ma do not appear in equilibrium with REE-rich garnet lobes, and younger zircons (278 Ma) show a new equilibrium with REE-poor garnet bights. On this basis, the DHREEamph/grt values obtained in specific textural sites might be interpreted as suggestive of equilibrium under granulite conditions.
SOME NOTES ON THE SHALLOW STRUCTURE HYPOTHESIS
Authors: Clahsen Harald , Felser Claudia 
Published: August 2017

AbstractSince the Shallow Structure Hypothesis (SSH) was first put forward in 2006, it has inspired a growing body of research on grammatical processing in nonnative (L2) speakers. More than 10 years later, we think it is time for the SSH to be reconsidered in the light of new empirical findings and current theoretical assumptions about human language processing. The purpose of our critical commentary is twofold: to clarify some issues regarding the SSH and to sketch possible ways in which this hypothesis might be refined and improved to better account for L1 and L2 speakers’ performance patterns.
International trade with pensions and demographic shocks
Authors: FEDOTENKOV IGOR , VAN GROEZEN BAS , MEIJDAM LEX 
Published: August 2017

AbstractThe central question of this paper is how international trade and specialization are affected by different designs of pension schemes and asymmetric demographic changes. In a model with two goods, two countries and two production factors, we find that countries with a relatively large unfunded pension scheme will specialize in the production of labour intensive goods. If these countries are hit by a negative demographic shock, this specialization will intensify in the long run. Eventually, these countries may even completely specialize in the production of those goods. The effects spill over to other countries, which will move away from complete specialization in capital intensive goods as the relative size of their labour intensive goods sector will also increase.
Photoelectrochemical oxidation of organic substrates in organic media
Authors: Li Tengfei , Kasahara Takahito , He Jingfu , Dettelbach Kevan E. , Sammis Glenn M. , Berlinguette Curtis P. 
Published: August 2017

AbstractThere is a global effort to convert sunlight into fuels by photoelectrochemically splitting water to form hydrogen fuels, but the dioxygen byproduct bears little economic value. This raises the important question of whether higher value commodities can be produced instead of dioxygen. We report here photoelectrochemistry at a BiVO4 photoanode involving the oxidation of substrates in organic media. The use of MeCN instead of water enables a broader set of chemical transformations to be performed (e.g., alcohol oxidation and C-H activation/oxidation), while suppressing photocorrosion of BiVO4 that otherwise occurs readily in water, and sunlight reduces the electrical energy required to drive organic transformations by 60%. These collective results demonstrate the utility of using photoelectrochemical cells to mediate organic transformations that otherwise require expensive and toxic reagents or catalysts.
Transport and excitations in a negative-U quantum dot at the LaAlO3/SrTiO3 interface
Authors: Prawiroatmodjo Guenevere E. D. K. , Leijnse Martin , Trier Felix , Chen Yunzhong , Christensen Dennis V. , von Soosten Merlin , Pryds Nini , Jespersen Thomas S. 
Published: August 2017

AbstractIn a solid-state host, attractive electron–electron interactions can lead to the formation of local electron pairs which play an important role in the understanding of prominent phenomena such as high Tc superconductivity and the pseudogap phase. Recently, evidence of a paired ground state without superconductivity was demonstrated at the level of single electrons in quantum dots at the interface of LaAlO3 and SrTiO3. Here, we present a detailed study of the excitation spectrum and transport processes of a gate-defined LaAlO3/SrTiO3 quantum dot exhibiting pairing at low temperatures. For weak tunneling, the spectrum agrees with calculations based on the Anderson model with a negative effective charging energy U, and exhibits an energy gap corresponding to the Zeeman energy of the magnetic pair-breaking field. In contrast, for strong coupling, low-bias conductance is enhanced with a characteristic dependence on temperature, magnetic field and chemical potential consistent with the charge Kondo effect.
Colossal permittivity behavior and its origin in rutile (Mg1/3Ta2/3)xTi1-xO2
Authors: Dong Wen , Chen Dehong , Hu Wanbiao , Frankcombe Terry J. , Chen Hua , Zhou Chao , Fu Zhenxiao , Wei Xiaoyong , Xu Zhuo , Liu Zhifu , Li Yongxiang , Liu Yun 
Published: August 2017

AbstractThis work investigates the synthesis, chemical composition, defect structures and associated dielectric properties of (Mg2+, Ta5+) co-doped rutile TiO2 polycrystalline ceramics with nominal compositions of (Mg2+1/3Ta5+2/3)
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O2. Colossal permittivity (>7000) with a low dielectric loss (e.g. 0.002 at 1 kHz) across a broad frequency/temperature range can be achieved at x = 0.5% after careful optimization of process conditions. Both experimental and theoretical evidence indicates such a colossal permittivity and low dielectric loss intrinsically originate from the intragrain polarization that links to the electron-pinned $${\bf{M}}{{\bf{g}}}_{{\bf{T}}{\bf{i}}}^{{\prime}{\prime} }+{{\bf{V}}}_{{\bf{O}}}^{\bullet \bullet }+{\bf{2}}{\bf{T}}{{\bf{a}}}_{{\bf{T}}{\bf{i}}}^{\bullet }+{\bf{2}}{\bf{T}}{{\bf{i}}}_{{\bf{T}}{\bf{i}}}^{\prime}$$
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defect clusters with a specific configuration, different from the defect cluster form previously reported in tri-/pent-valent ion co-doped rutile TiO2. This work extends the research on colossal permittivity and defect formation to bi-/penta-valent ion co-doped rutile TiO2 and elucidates a likely defect cluster model for this system. We therefore believe these results will benefit further development of colossal permittivity materials and advance the understanding of defect chemistry in solids.
Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model
Authors: El-Hashim Ahmed Z. , Khajah Maitham A. , Renno Waleed M. , Babyson Rhema S. , Uddin Mohib , Benter Ibrahim F. , Ezeamuzie Charles , Akhtar Saghir 
Published: August 2017

AbstractThe molecular mechanisms underlying asthma pathogenesis are poorly characterized. In this study, we investigated (1) whether Src mediates epidermal growth factor receptor (EGFR) transactivation; (2) if ERK1/2, PI3Kδ/Akt and NF-κB are signaling effectors downstream of Src/EGFR activation; and (3) if upstream inhibition of Src/EGFR is more effective in downregulating the allergic inflammation than selective inhibition of downstream signaling pathways. Allergic inflammation resulted in increased phosphorylation of EGFR, Akt, ERK1/2 and IκB in the lung tissues from ovalbumin (OVA)-challenged BALB/c mice. Treatment with inhibitors of Src (SU6656) or EGFR (AG1478) reduced EGFR phosphorylation and downstream signaling which resulted in the inhibition of the OVA-induced inflammatory cell influx in bronchoalveolar lavage fluid (BALF), perivascular and peribronchial inflammation, fibrosis, goblet cell hyper/metaplasia and airway hyper-responsiveness. Treatment with pathway-selective inhibitors for ERK1/2 (PD89059) and PI3Kδ/Akt (IC-87114) respectively, or an inhibitor of NF-κB (BAY11-7085) also reduced the OVA-induced asthmatic phenotype but to a lesser extent compared to Src/EGFR inhibition. Thus, Src via EGFR transactivation and subsequent downstream activation of multiple pathways regulates the allergic airway inflammatory response. Furthermore, a broader upstream inhibition of Src/EGFR offers an attractive therapeutic alternative in the treatment of asthma relative to selectively targeting the individual downstream signaling effectors.
Evaluation of the condyle remodeling after lateral arthroplasty in growing children with temporomandibular joint ankylosis
Authors: Yang XiuJuan , Lu Chuan , Dong MinJun , He DongMei , Yang Chi , Hu YiHui 
Published: August 2017

AbstractTemporomandibular joint (TMJ) ankylosis in growing patients can cause both mouth opening limitation and jaw bone deformity. Lateral arthroplasty (LAP) can restore the medially displaced condyle and thus keep its growth potential. But can the condyle grow as normal is unknown. This study was to evaluate the long-term result after LAP in growing children. Patients from 2010 to 2014 were evaluated. Their CT data within 1 week after operation and during at least 1-year follow-ups were measured by ProPlan CMF 1.4 software. The condyle-ramus length of both sides and angles and the chin deviation before and after operation were compared. SPSS 17.0 software was used for statistical analysis. A total of 9 patients with a mean age of 10.2 years were included in the study. The mean follow-up period was 1.94 years. The mean condyle-ramus growth was 2.90 mm in the affected side and 2.50 mm in the unaffected side (P = 0.31). All of the affected side exhibited growth and remodeling of the condyle and ramus. All 9 cases had a mean chin deviation of 3.69 mm before operation and 2.92 mm during follow-ups (P = 0.16). The residual condyle grows after LAP, which can reduce the gravity of jawbone deformity.
Electrically Tunable Metamaterials Based on Multimaterial Nanowires Incorporating Transparent Conductive Oxides
Authors: Salary Mohammad Mahdi , Mosallaei Hossein 
Published: August 2017

AbstractWe present novel design approaches for metasurfaces and metamaterials with electrical tunability offering real-time manipulation of light and serving as multifunctional devices in near-infrared frequency regime (at the specific wavelength of 1.55 μm). For this purpose, we integrate indium-tin-oxide (ITO) as a tunable electro-optical material into multimaterial nanowires with metal-oxide-semiconductor and metal-insulator-metal configurations. In particular, an active metasurface operating in the transmission mode is designed which allows for modulation of the transmitted light phase over 280 degrees. This large phase modulation is afforded in the cost of low transmission efficiency. We demonstrate the use of such active metasurfaces for tunable bending and focusing in free-space. Moreover, we investigate the implementation of this material in deeply subwavelength multimaterial nanowires, which can yield strong variations in the effective refractive index by the virtue of internal homogenization enabling tunability of the performance in gradient refractive index metamaterials. In the theoretical modeling of these structures, we adopt a hierarchical multiscale approach by linking drift-diffusion transport model with the electromagnetic model which rigorously characterizes the electro-optical effects.
Visible light high-resolution imaging system for large aperture telescope by liquid crystal adaptive optics with phase diversity technique
Authors: Xu Zihao , Yang Chengliang , Zhang Peiguang , Zhang Xingyun , Cao Zhaoliang , Mu Quanquan , Sun Qiang , Xuan Li 
Published: August 2017

AbstractThere are more than eight large aperture telescopes (larger than eight meters) equipped with adaptive optics system in the world until now. Due to the limitations such as the difficulties of increasing actuator number of deformable mirror, most of them work in the infrared waveband. A novel two-step high-resolution optical imaging approach is proposed by applying phase diversity (PD) technique to the open-loop liquid crystal adaptive optics system (LC AOS) for visible light high-resolution adaptive imaging. Considering the traditional PD is not suitable for LC AOS, the novel PD strategy is proposed which can reduce the wavefront estimating error caused by non-modulated light generated by liquid crystal spatial light modulator (LC SLM) and make the residual distortions after open-loop correction to be smaller. Moreover, the LC SLM can introduce any aberration which realizes the free selection of phase diversity. The estimating errors are greatly reduced in both simulations and experiments. The resolution of the reconstructed image is greatly improved on both subjective visual effect and the highest discernible space resolution. Such technique can be widely used in large aperture telescopes for astronomical observations such as terrestrial planets, quasars and also can be used in other applications related to wavefront correction.
Activation of NADPH oxidases leads to DNA damage in esophageal cells
Authors: Bhardwaj Vikas , Gokulan Ravindran Caspa , Horvat Andela , Yermalitskaya Liudmila , Korolkova Olga , Washington Kay M. , El-Rifai Wael , Dikalov Sergey I. , Zaika Alexander I. 
Published: August 2017

AbstractGastroesophageal reflux disease (GERD) is the strongest known risk factor for esophageal adenocarcinoma. In the center of tumorigenic events caused by GERD is repeated damage of esophageal tissues by the refluxate. In this study, we focused on a genotoxic aspect of exposure of esophageal cells to acidic bile reflux (BA/A). Analyzing cells generated from patients with Barrett’s esophagus and human esophageal specimens, we found that BA/A cause significant DNA damage that is mediated by reactive-oxygen species. ROS originate from mitochondria and NADPH oxidases. We specifically identified NOX1 and NOX2 enzymes to be responsible for ROS generation. Inhibition of NOX2 and NOX1 with siRNA or chemical inhibitors significantly suppresses ROS production and DNA damage induced by BA/A. Mechanistically, our data showed that exposure of esophageal cells to acidic bile salts induces phosphorylation of the p47phox subunit of NOX2 and its translocation to the cellular membrane. This process is mediated by protein kinase C, which is activated by BA/A. Taken together, our studies suggest that inhibition of ROS induced by reflux can be a useful strategy for preventing DNA damage and decreasing the risk of tumorigenic transformation caused by GERD.
Properties of residual titanium dioxide nanoparticles after extended periods of mixing and settling in synthetic and natural waters
Authors: Zhang Chunpeng , Lohwacharin Jenyuk , Takizawa Satoshi 
Published: August 2017

AbstractTitanium dioxide nanoparticle (TiO2 NP) discharged into water bodies can affect ecosystems and human health adversely. We studied the properties of residual TiO2 NPs with and without gentle mixing (to simulate a natural environment more closely) and after settling for 12-h periods. Surface complexation, dynamic particle size changes, and TiO2 NP destabilization in synthetic and lake waters were investigated. The accumulation of inert ions (Na+ and Cl−) in the diffuse layer which was not discussed in other studies was supposed to be the main reason that aggregation occurred slowly and continuously. PO43− stabilized and destabilized TiO2 NPs at 10 mM and 100 mM, respectively. Destabilization occurred because high ionic strength overwhelmed increased negative charges of TiO2 NPs by complexation with PO43−. TiO2 NP destabilization was achieved in approximately 12 h in synthetic and lake waters, and is attributed to the slow diffusion of ions into aggregates. Despite the presence of moderately high concentrations of natural organic matter, which tends to stabilize TiO2 NPs, the addition of 20 mM PO43− destabilized the TiO2 NPs in lake water. Smaller aggregate sizes formed compared with those before destabilization, which indicates that stable residual TiO2 NPs could exist in aquatic environments after extended periods.