bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplexed SERS Detection of Serum Cardiac Markers Using Plasmonic Metasurfaces
Authors: Zheng Peng , Wu Lintong , Raj Piyush , Kim Jeong Hee , Paidi Santosh Kumar , Semancik Steve , Barman Ishan 
Published: October 2024

AbstractSurface‐enhanced Raman spectroscopy (SERS) possesses exquisite molecular‐specific properties with single‐molecule sensitivity. Yet, translation of SERS into a quantitative analysis technique remains elusive owing to considerable fluctuation of the SERS intensity, which can be ascribed to the SERS uncertainty principle, a tradeoff between “reproducibility” and “enhancement”. To provide a potential solution, herein, an integrated multiplexed SERS biosensing strategy is proposed, which features two distinct advantages. First, a subwavelength‐structured plasmonic metasurface consisting of alternately stacked metal–dielectric pyramidal meta‐atoms is fabricated and could provide simultaneously enhanced electric and magnetic fields to enable spatially extended and weakly wavelength‐dependent SERS. Second, nanomechanical perturbations are harnessed to transduce signals in the form of SERS frequency shifts, which are not directly affected by the SERS uncertainty principle. By also employing 3D printing methods, a proof‐of‐concept study of multiplexed detection of a panel of serum cardiac biomarkers for acute myocardial infarction is provided. Success in the development of both the electric and magnetic fields‐active plasmonic metasurfaces could transform future designs of SERS substrates with newly endowed functionalities, and frequency shift‐based SERS multiplexing could open new opportunities to develop innovative quantitative optical techniques for applications in chemistry, biology, and medicine.
Thermally Drawn Polymeric Catheters for MR‐Guided Cardiovascular Intervention
Authors: Abdelaziz Mohamed E. M. K. , Tian Libaihe , Lottner Thomas , Reiss Simon , Heidt Timo , Maier Alexander , Düring Klaus , Mühlen Constantin von zur , Bock Michael , Yeatman Eric , Yang Guang‐Zhong , Temelkuran Burak 
Published: October 2024

AbstractCardiovascular diseases (CVDs), including congenital heart diseases (CHD), present significant global health challenges, emphasizing the need for safe and effective treatment modalities. Fluoroscopy‐guided endovascular interventions are widely utilized but raise concerns about ionizing radiation, especially in pediatric cases. Magnetic resonance imaging (MRI) offers a radiation‐free alternative with superior soft tissue visualization and functional insights. However, the lack of compatible instruments remains a major obstacle. An adapted thermal drawing platform that enables low‐cost and rapid prototyping of instruments for MR‐guided endovascular interventions is introduced. This platform is demonstrated through the development of two exemplary catheter systems: a tendon‐driven steerable catheter with helical lumina and an active tracking Tiger‐shaped catheter with an embedded coaxial wire. These catheters exhibit mechanical properties comparable to commercial counterparts and show promising outcomes in both in vitro and in vivo feasibility testing. This scalable thermal drawing platform addresses the limitations of existing manufacturing approaches and facilitates the exploration of diverse designs, potentially accelerating advancements in catheter technologies for MR‐guided cardiovascular interventions.
Toxic Effects of Tributyltin, Triphenyltin, and SnCl2 on the Development of Zebrafish (Danio rerio) Embryos
Authors: Barkhordari Aref , Hassan Jalal , Koohi Mohammad Kazem , Rahmati‐Holasoo Hooman , Pourshaban‐Shahrestani Ali 
Published: October 2024

ABSTRACTTin (Sn) is one of the heavy metals to which various functions in biological development are attributed in small quantities, for example, a role in cell structure, enzyme activities, and protein and carbohydrate metabolism in fish. Tributyltin (TBT) and triphenyltin (TPT) are endocrine disrupting chemicals that are widely distributed in the aquatic environment. The aim of this study was to investigate the effects of TBT, TPT, and SnCl2 on the embryonic development of zebrafish. In this study, zebrafish embryos were used to observe the acute toxicity of TBT, TPT, and SnCl2. Fish embryo toxicity analysis was performed for different TBT, TPT, and SnCl2 concentrations (1, 5, 10, 15, and 20 ng/L). Fertilized eggs in 24‐well plates (20 eggs in each concentration) were incubated at 26°C for 4 days, and embryo clotting, embryo heartbeat, and morphological abnormalities were recorded after 96 h. Coagulation increased significantly in a dose‐dependent manner, and TBT was able to induce coagulation in zebrafish embryos. Heartbeat changes significantly decreased (p < 0.05) in a dose‐dependent manner at different TBT doses (p < 0.05). The percentage of mortality was higher in embryos at trace levels of TBT, indicating that the embryos are more sensitive to the toxicity of TBT. TBT is therefore extremely toxic and can have fatal consequences for zebrafish embryos, ultimately leading to the extinction of species and a decline in biodiversity in the aquatic environment. After analyzing the images 96 h after fertilization and converting them to a teratogenic index score, it was found that the index for the two compounds TPT and TBT was 4.6 and 9.6 ng/L, respectively.
An Unusual Presentation of Leber Hereditary Optic Neuropathy‐Plus Case Caused by a Novel DNAJC30 Variant
Authors: Şenol Hüseyin Bahadır , Soydemir Didem , Polat Ayşe İpek , Aydın Adem , Hız Ayşe Semra , Yiş Uluç 
Published: October 2024

ABSTRACTLeber hereditary optic neuropathy (LHON) is characterized by vision loss due to the degeneration of retinal ganglion cells. LHON‐Plus refers to LHON with additional extraocular findings. Neurological conditions observed in LHON‐Plus include seizures, encephalopathy, movement disorders, neuropathy, and myopathy. Herein, we present a case with atypical LHON‐Plus caused by a novel DNAJC30 disease‐causing gene variant. A 15‐year‐old boy presented with acute headache, and blurred and decreased vision in both eyes. Although initial evaluation pointed toward idiopathic intracranial hypertension, the subsequent diagnostic process revealed unusual features like area postrema syndrome and T2 hyperintensity in brain magnetic resonance imaging. Consequently, antibody‐negative neuromyelitis optica spectrum disorder (NMOSD) was diagnosed and treatment was commenced. Recurrent episodes of elevated intracranial pressure necessitated the insertion of a ventriculoperitoneal shunt. Exome sequencing (ES) revealed a novel homozygous variant in the DNAJC30 gene 2 years after symptom onset. Atypical LHON presentations due to nuclear gene mutations may mimic other neuroinflammatory conditions like NMOSD, necessitating thorough clinical evaluation and genetic testing. ES plays a crucial role in diagnosing complex neurological cases, enabling the identification of novel genetic variants associated with LHON and related disorders.
Research progress in OX40/OX40L in allergic diseases
Authors: Song Rongrong , Zhang Huanlei , Liang Zhuoping 
Published: October 2024

AbstractOX40/OX40L are costimulatory molecules in the tumor necrosis factor superfamily. Numerous studies have shown that OX40/OX40L are involved in immune regulation, especially in the proliferation and differentiation of T cells and the generation of memory T cells, which play important roles in allergic diseases. In recent years, the use of OX40/OX40L as therapeutic targets for treating T‐cell‐mediated diseases has attracted the interest of scholars. This paper reviews the role of OX40/OX40L in allergic diseases and the progress in clinical treatments targeting this signaling pathway.
A‐Site Engineering with Thiophene‐Based Ammonium for High‐Efficiency 2D/3D Tin Halide Perovskite Solar Cells
Authors: Feng Guitao , Loi Hok‐Leung , Wang Tianyue , Deng Wenqiu , Guan Zhiqiang , Wei Qi , He Jiandong , Li Mingjie , Lee Chun‐Sing , Wang Jizheng , Zhang Qichun , Yan Feng 
Published: October 2024

AbstractTin halide perovskites are the most promising candidate materials for lead‐free perovskite solar cells (PSCs) thanks to their low toxicity and ideal band gap energies. The introduction of 2D/3D mixed perovskite phases in tin‐based PSCs (TPSCs) has proven to be the most effective approach to improving device efficiency and stability. However, a 2D perovskite phase normally shows relatively low carrier mobility, which will be unfavorable for carrier transfer in the devices. In this work, we used a thiophene‐based cation 2‐(thiophen‐3‐yl)ethan‐1‐aminium (3‐TEA) as a spacer to form a novel 2D perovskite phase in TPSCs, which shows the most promising effect on the performance enhancement in comparison with other cations like 2‐(thiophen‐2‐yl)ethan‐1‐aminium (2‐TEA) and benzene‐based 2‐phenylethan‐1‐aminium (PEA). Theoretical calculations reveal that 3‐TEA enables the most compact crystal packing of [SnI6]4− octahedral layers, resulting in the lowest hole effective mass and formation energy in the 2D phase. This effect significantly enhances device efficiency and stability by facilitating more efficient carrier transfer within the 2D phase. These findings indicate that thiophene‐based 2D perovskites are well‐suited for high‐performance TPSCs.
Das Trifluoroxygenat‐Anion [OF3]−: Spektroskopischer Nachweis einer Binären, Hypervalenten Sauerstoffspezies
Authors: Meyer Deniz F. , Medel Robert , Riedel Sebastian 
Published: October 2024

AbstractExperimentelle Belege für hypervalente Verbindungen von Elementen der zweiten Periode sind in der Literatur selten. In dieser Arbeit berichten wir erstmals über das lange gesuchte binäre, hypervalente Trifluoroxygenat‐Anion [OF3]−. Es wurde gebildet durch die Reaktion von Sauerstoffdifluorid mit freien Fluorid‐Ionen, welche durch Laserablation von Alkalimetallfluoriden MF (M=Li−Cs) erzeugt wurden, und konnte unter kryogenen Bedingungen in Neonmatrizen isoliert werden. Das VSEPR‐Modell und Berechnungen auf CCSD(T)‐Niveau sagen eine C2v‐symmetrische T‐förmige Struktur mit einer kurzen und zwei langen O−F‐Bindungen für [OF3]− voraus. Dies wird durch FTIR‐Spektroskopie in Kombination mit Isotopenmarkierungs‐Experimente bestätigt. Eine Analyse der natürlichen lokalisierten Molekülorbitale zeigt das Vorliegen einer 2Z–2E‐Bindung und einer 3Z–4E‐Bindung an. Natural Resonance Theory weist auf die Bedeutung der Stabilität von [OF2]⋅− für die Stabilität von [OF3]− hin. Obwohl freies [OF2]⋅− nicht nachgewiesen wurde, konnten in denselben Experimenten die Spezies MOF2 (M=Na−Cs) beobachtet werden, die sich am besten als Kontaktionenpaar M+[OF2]⋅− beschreiben lassen.
One‐Step Synthesis of Novel Erlotinib Analogs Catalyzed by Nano‐CuO as Potent Anticancer Agent
Authors: Moghadam Fatemeh Azmian , Mokhtary Masoud , Evazalipour Mehdi 
Published: October 2024

ABSTRACTTwenty new substituted erlotinib analogs with anticancer activity were produced with good to excellent yields through the one‐step reaction of erlotinib, aromatic aldehydes, and cyclic secondary amines such as piperidine, morpholine, pyrrolidine, N‐methylpiperazine, or imidazole using nano‐CuO in choline chloride: urea (ChCl:urea) solvent under ultrasound irradiation at 80°C. MTT protocol was applied to investigate the cytotoxicity of all produced substituted erlotinib analogs in A431 (human epidermoid carcinoma cell) and HU02 (foreskin fibroblast) cell lines. The results illustrated that at a concentration of less than 10 μM, the growth of A431 cells could be inhibited by the produced compounds. Compared to erlotinib as positive control, the highest cytotoxic activity with IC50 equal to 2.58 ± 0.57 μM belonged to compound 4c carrying 4‐fluorobenzene with piperidine substitution. All of the synthesized compounds showed significant cytotoxic activity on A431, while showing no apparent cytotoxicity to HU02. The reasons for the stronger cytotoxic activity 4c can be most probably attributed to the two phenomena of greater solubility of the fluoro derivative and the flexibility of piperidine. Based on this study, compound 4c is the most promising compound with anticancer properties.
Heart Engineering of Photovoltaic Devices: Preparation of New Ru Dyes Using Thioindigo and Phenothiazine
Authors: Hosseinnezhad Mozhgan , Nasiri Sohrab , Nutalapati Venkatramaiah , Gharanjig Kamaladin , Nunzi Jean Michel 
Published: October 2024

ABSTRACTPhenothiazine and thioindigo were used as substitutes to make new Ru dyes for DSSCs. The thioindigo unit is a notable molecule with strong technical qualities in these photosensitizers. As a result, research was done on the cyano substituent as an electron‐donating group. Both theoretical and experimental methods were used to assess the complexes' optical response. A better photovoltaic response is achieved by the cyano groups' efficient bonding with the semiconductor layer. Additionally, the complexes that were formed contain two different kinds of electron accepter substituents: cyanoacrylic acid and carboxylic acid, with efficiencies of 7.42% and 4.17%, respectively. Additionally, cosensitization was investigated and analyzed utilizing N719 and two generated complexes. DSSCs made with Complex 1 and 2 and N719 have corresponding efficiency percentages of 8.86% and 9.74%.
High Quantum Yields and Energy Transfer Efficiency of Lanthanide‐Based Coordination Polymers as Luminescent Thermometer in Low Temperature Range
Authors: Wang Jinzeng , Dong Jinning , Cui Mengjuan , Li Xiaolong , Wang Fang 
Published: October 2024

ABSTRACTLuminescent lanthanide‐based coordination polymers (LnCPs) present great potential in low‐temperature detection due to their convenience in contactless readout. High quantum yields and energy transfer efficiency are favored by LnCPs as luminescent thermometer. In this work, based on the thermogravimetric analysis and temperature‐dependent powder x‐ray diffraction, coordinated and isolated molecules of [Ln2(mip)3(H2O)8·4H2O]∞ (abbreviated as Ln2MIP) were removed by dehydration process. Combining luminescent measurement and calculation, both quantum yields and energy transfer efficiency between Tb3+ and Eu3+ have been greatly enhanced. Additionally, the Eu3+ intensity of dehydrated Gd0.2Tb1.08Eu0.72MIP displays excellent temperature sensing ability from 77 to 300 K with enhanced relative sensitivity. These results demonstrate the potential of LnCPs in low‐temperature sensing with high quantum yields and energy transfer efficiency.
Kia kōrerorero tonu ai: a review of the dialogue at the interface of Indigenous oral tradition and archaeology in Aotearoa New Zealand and Oceania
Authors: McIvor Isaac , Roa Tom , Waitoki Waikaremoana 
Published: October 2024

ABSTRACTThis paper examines the previous theoretical interfaces of Indigenous oral tradition and archaeology in Oceania, specifically in Aotearoa (New Zealand). Historical processes of writing down kōrero, or oral histories, by amateur historians and ethnologists in the late 19th and early 20th centuries, culminated in the romanticised traditions of the early Polynesian society and influenced contemporary archaeological scholarship. In response to criticisms, archaeologists attempted to validate kōrero using Western research methodologies. However, attempts often fell short and processual archaeologists of the mid‐late‐20th century considered oral tradition and archaeology as incapable of cross‐validation. Parallel ethnological scholarship focused on the symbolism in oral histories as indicators of their function in contemporary society or as legitimate forms of recounting actual historical events after critical evaluation. More recent archaeologists use kōrero about the last few centuries like any other historical source. Māori scholars have taken inspiration from previous theoretical arcs to position kōrero in a postmodern space of relative truths or to critically analyse its historical and functional values. The review concludes with how the interface of oral history and archaeology might follow Kaupapa Māori research methodologies and current materialist critiques of dominant settlement pattern theory.
Ein neues Rathaus für Hainburg
Authors: Kühn Noel , Rutschmann Andreas 
Published: October 2024

AbstractDas neue Rathausgebäude in Hainburg vereint die Verwaltungen der Rathäuser Hainstadt und Klein‐Krotzenburg unter einem Dach. Das Haus wirkt in seiner Formensprache nicht wie ein klassischer Verwaltungsbau. Durch die großzügige Rücknahme des Erdgeschosses über eine Gebäudeecke und ein dahinter anschließendes gebäudehohes Atrium wirkt der Baukörper vielmehr wie ein leichter, einladender Pavillon mit Aufenthaltsqualität. Das Gebäude wurde in Holzbauweise errichtet. Der Holzbau ist nicht nur Bestandteil der Konstruktion, sondern auch gestaltendes Element im Innenraum. Einzig das Untergeschoss und der aussteifende Kern wurden in Massivbauweise ausgeführt. Neben dem Einsatz nachhaltiger Materialien folgt auch das Energiekonzept des Rathauses modernsten Ansprüchen. Die Stromversorgung des gesamten Gebäudes sowie der Betrieb der Luft/Wasser‐Wärmepumpen für die Fußbodenheizung werden vollständig über eine Photovoltaikanlage auf dem Dach abgedeckt. Die vertikal strukturierte Fassade erhielt eine Verkleidung aus bronzierten Blechen. Das darauf fallende Tageslicht erhöht den Eindruck eines Bauwerks von hoher architektonischer Qualität. Der vorliegende Beitrag beschreibt die planerischen Randbedingungen des Projekts und den Versuch einer konsequenten Umsetzung der architektonischen Idee im Tragwerk. Ein Schwerpunkt widmet sich der Betrachtung des ermittelten CO2‐Äquivalents am Beispiel der Decke über dem 1. OG.
Understanding the long‐term impact of the COVID‐19 pandemic on non‐muscle‐invasive bladder cancer outcomes: 12‐Month follow‐up data from the international, prospective COVIDSurg Cancer study
Authors: Alexander Cameron E. , Nathan Arjun , Light Alexander , Gao Chuanyu , Chan Vinson , Khadhouri Sinan , Gallagher Kevin , Byrnes Kevin G. , Walters Michael , Hughes Terry , Perry Rita , Okoth Kelvin , Magill Laura , Pinkney Thomas , John Joseph B. , McGrath John S. , Colquhoun Alexandra , Zhang Yuhao , Blackmur James , Etchill Eric , Tang Stanley , García Escudero Damián , Stewart Grant D. , Kasivisvanathan Veeru ,   COVIDSurg Collaborative
Published: October 2024

AbstractObjectiveThe objective of this study was to report the 12‐month oncological outcomes for patients with non‐muscle‐invasive bladder cancer (NMIBC) within the prospective, international COVIDSurg Cancer study.Patients and methodsEligible patients were aged ≥18 years and scheduled for elective surgical management of NMIBC with curative intent (transurethral resection of bladder tumour [TURBT] or bladder biopsy) from 21 January to 14 April 2020. The primary outcome was disease recurrence within 12 months of previous elective TURBT/bladder biopsy. Secondary outcomes included disease progression within 12 months of previous elective TURBT/bladder biopsy, site‐declared delay to surgery from diagnosis as a consequence of COVID‐19 and deviation in standard care due to COVID‐19. Comparisons were made to cohorts from the pre‐pandemic era.ResultsBladder cancer accounted for 2.2% (n = 446) of patients in the COVIDSurg Cancer study, with data contributed by 27 centres across 12 countries internationally. Within this included cohort, 229 patients had NMIBC and 12‐month follow‐up data available. On application of National Institute for Health and Care Excellence (NICE) criteria, 47.2% were classified as having high‐risk disease. Overall disease recurrence and progression rates were 29.3% and 9.7% at 12 months, respectively. In purely high‐risk pre‐pandemic cohorts, the International Bladder Cancer Group (IBCG) estimates a recurrence rate of 25% at 12 months, and the European Association of Urology (EAU) NMIBC 2021 scoring model estimates a 12‐month progression rate of 3.5%. As a consequence of the COVID‐19 pandemic, 10.9% of patients had site‐declared delay to TURBT/bladder biopsy; 7.4% did not undergo intravesical therapy or had early discontinuation of this; 9.2% did not undergo early repeat resection for high‐risk disease; and 18.3% had a delay to cystoscopic follow‐up surveillance.ConclusionsThis prospective study indicates that there were widespread deviations in usual care for NMIBC during the pandemic and that 12‐month oncological outcomes appear to be impaired compared to published pre‐pandemic outcomes.
Reliability of mpMRI in diagnosing cancer prostate following intravesical BCG for bladder cancer
Authors: Avudaiappan Arjun Pon , Prabhakar Pushan , Siretskiy Rachel , Renshaw Andrew , Eldefrawy Ahmed , Manoharan Murugesan 
Published: October 2024

AbstractBackgroundDetecting carcinoma prostate (CaP) after intravesical Bacillus Calmette Guerin (BCG) immunotherapy for non‐muscle invasive bladder cancer (NMIBC) poses diagnostic challenges. Granulomatous prostatitis (GP) has an incidence of 0.8%–3.3% in post‐intravesical BCG patients and 6% incidence in a PIRADS 5 lesion on multiparametric MRI (mpMRI). Patients with GP after intravesical BCG may have clinical, biochemical, and radiological features similar to CaP. In our study, we evaluate the reliability of mpMRI in diagnosing CaP after intravesical BCG therapy.Materials and MethodsWe reviewed the NMIBC patients treated with intravesical BCG therapy between 2017 and 2023 and investigated those who underwent mpMRI and MR fusion biopsy in suspicion of CaP. A total of 120 patients had intravesical BCG immunotherapy, and 10 patients met our selection criteria. We performed a descriptive analysis of these patients and assessed the sensitivity and specificity of mpMRI in diagnosing CaP.ResultsThe sensitivity of mpMRI in detecting CaP was 100%, and the specificity was 28.6%. Similarly, the negative predictive value for detecting CaP was 100%, and the positive predictive value was 37.5%. Among patients evaluated with mpMRI, a PIRADS 4 or 5 lesion was seen in 8 (80%) patients, and there was no lesion in 2 (20%) patients. The mpMRI detected 1 lesion in 6 patients (60%) and 2 (20%) in 2 patients. The lesions had a PIRADS score of 4 and 5 in 6 (60%) and 2 (20%) patients, respectively. Among these lesions, 8 (80%) were in the peripheral zone and 2 (20%) in the transition zone. In the MR fusion biopsy of these 10 patients, 7 (70%) had granulomatous prostatitis, and 3 (30%) had CaP.ConclusionIn our study on evaluating the reliability of mpMRI in diagnosing CaP among post‐intravesical BCG patients, we noted that although PIRADS in mpMRI had high sensitivity in identifying prostate lesions, its specificity for detecting CaP is limited.
Nichtlineare Analyse des Tragverhaltens von gefalteten Carbonbetonmodulen
Authors: Spartali Homam , Gomes Carlos , Klarmann Simon , Klinkel Sven , Chudoba Rostislav 
Published: October 2024

AbstractSteigende Anforderungen an die Nachhaltigkeit von Bauwerken erfordern den Übergang von massiven zu dünnwandigen, hocheffizienten Bauteilen. Basierend auf der Faltbarkeit textiler Bewehrungen bieten dünnwandige Origami‐Faltschalen aus Carbonbeton eine effizient herstellbare Alternative zu traditionellen Stahlbetonstrukturen. Trotz intensiver Forschung existieren bislang keine etablierten Bemessungs‐ und Analysemethoden, die eine hinreichend genaue Vorhersage des Tragverhaltens gefalteter Schalen erlauben und somit eine zielgerichtete Entwicklung hinsichtlich Tragfähigkeit, Spannungsumlagerungen und Versagensmechanismen unterstützen können. Vor diesem Hintergrund werden zwei FEM‐Modellierungsansätze zur Analyse von Faltschalenmodulen vorgestellt. In diesen Ansätzen wird die Carbonbewehrung sowohl in verschmierter als auch in aufgelöster Form modelliert. Das Materialverhalten des Betons wird mithilfe eines Schädigungsplastizitätsmodells abgebildet. Der Modellierungsansatz wird anhand von getesteten Prototypen validiert. Der Ansatz bildet eine allgemeine Grundlage für den Entwurf und die Analyse gefalteter Origami‐Schalen.