bluuebunny/crossref_metadata_2025_split huggingface dataset:
Special-form radial collateral artery perforator flaps for the reconstruction of complex hand defects
Authors: Xiong Yu , Xiong Qin , Qing Li-Ming , Wu Pan-Feng , Tang Ju-Yu , Yu Fang 
Published: September 2024

Abstract
Background
The reconstruction of complex wounds of the hand still has challenges in achieving aesthetic, functional and sensory recovery. We presented our experience of using the polyfoliate and chimeric radial collateral artery perforator flaps (RCAPF) to repair complex hand defects, aiming to explore the feasibility of special-form RCAPFs in hand coverage and enhance the comprehension of their respective indications.

Methods
From June 2014 to March 2021, 26 cases (19 males and 7 females, mean 44.4 years) underwent defect and sensation reconstruction of their hands with special-form RCAPFs, which manifested as multiple adjacent or irregular single wounds and composite tissue defects complicated with a degree of nerve injury. The clinical effects of the free RCAPFs were evaluated by integrating the postoperative and long-term follow-up outcomes of all cases.

Results
Altogether 8 polyfoliate flaps, 17 chimeric flaps and 1 polyfoliate-chimeric flap were harvested. Of them, 23 flaps survived uneventfully in one stage. Venous congestion occurred in 3 cases, two of which survived through vascular exploration and another one was finally repaired by the contralateral RCAPF. The follow-up results showed that the appearance of both the recipient and donor sites mostly recovered satisfactory. All the bone flaps properly healed. The BMRC sensory evaluation results of all skin flaps were S4 in 8 flaps, S3 in 18 flaps, and S2 in 9 flaps.

Conclusions
The free RCAPFs can be designed in various forms with a reliable blood supply, contributing to reconstructing simple and multiple wounds of the hand with or without bone defects and dead space.
Identification of LINC02454-related key pathways and genes in papillary thyroid cancer by weighted gene coexpression network analysis (WGCNA)
Authors: Song Yingjian , Wang Lin , Ren Yi , Zhou Xilei , Tan Juan 
Published: September 2024

Abstract
Background
Our previous study demonstrated that long intergenic noncoding RNA 02454 (LINC02454) may act as an oncogene to promote the proliferation and inhibit the apoptosis of papillary thyroid cancer (PTC) cells. This study was designed to investigate the mechanisms whereby LINC02454 is related to PTC tumorigenesis.

Methods
Thyroid cancer RNA sequence data were obtained from The Cancer Genome Atlas (TCGA) database. Weighted gene coexpression network analysis (WGCNA) was applied to identify modules closely associated with PTC. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was used to identify the key pathways, and the maximal clique centrality (MCC) topological method was used to identify the hub genes. The Gene Expression Profiling Interactive Analysis (GEPIA) database was used to compare expression levels of key genes between PTC samples and normal samples and explore the prognostic value of key genes. The key genes were further validated with GEO dataset.

Results
The top 5000 variable genes were investigated, followed by an analysis of 8 modules, and the turquoise module was the most positively correlated with the clinical stage of PTC. KEGG pathway analysis found the top two pathways of the ECM − receptor interaction and MAPK signaling pathway. In addition, five key genes (FN1, LAMB3, ITGA3, SDC4, and IL1RAP) were identified through the MCC algorithm and KEGG analysis. The expression levels of the five key genes were significantly upregulated in thyroid cancer in both TCGA and GEO datasets, and of these five genes, FN1 and ITGA3 were associated with poor disease-free prognosis.

Conclusions
Our study identified five key genes and two key pathways associated with LINC02454, which might shed light on the underlying mechanism of LINC02454 action in PTC.
Surgical site infection in severe trauma patients in intensive care: epidemiology and risk factors
Authors: Savio Lucie , Simeone Pierre , Baron Sophie , Antonini François , Bruder Nicolas , Boussen Salah , Zieleskiewicz Laurent , Blondel Benjamin , Prost Solène , Baucher Guillaume , Lebaron Marie , Florant Thibault , Boucekine Mohamed , Leone Marc , Velly Lionel 
Published: September 2024

Abstract
Background
Severe trauma is the leading cause of disability and mortality in the patients under 35 years of age. Surgical site infections (SSI) represent a significant complication in this patient population. However, they are often inadequately investigated, potentially impacting the quality of patient outcomes. The aim of this study was to investigate the epidemiology of SSI and risk factors in severe trauma patients.

Methods
We conducted a multicenter retrospective cohort study screening the severe trauma patients (STP) admitted to two intensive care units of an academic institution in Marseille between years2018 and 2019. Those who underwent orthopedic or spinal surgery within 5 days after admission were included and classified into two groups according to the occurrence of SSI (defined by the Centers for Disease Control (CDC) international diagnostic criteria) or not. Our secondary goal was to evaluate STP survival at 48 months, risk factors for SSI and microbiological features of SSI.

Results
Forty-seven (23%) out of 207 STP developed an SSI. Mortality at 48-months did not differ between SSI and non-SSI patients (12.7% vs. 10.0%; p = 0.59). The fractures of 22 (47%) severe trauma patients with SSI were classified as Cauchoix 3 grade and 18 (38%) SSI were associated with the need for external fixators. Thirty (64%) severe trauma patients with SSI had polymicrobial infection, including 34 (72%) due to Gram-positive cocci. Empirical antibiotic therapy was effective in 31 (66%) cases. Multivariate analysis revealed that risk factors such as low hemoglobin, arterial oxygenation levels, hyperlactatemia, high serum creatinine and glycemia, and Cauchoix 3 grade on the day of surgery were associated with SSI in severe trauma patients. The generated predictive model showed a good prognosis performance with an AUC of 0.80 [0.73–0.88] and a high NPV of 95.9 [88.6–98.5] %.

Conclusions
Our study found a high rate of SSI in severe trauma patients, although SSI was not associated with 48-month mortality. Several modifiable risk factors for SSI may be effectively managed through enhanced perioperative monitoring and the implementation of a patient blood management strategy.
The solute carrier transporters (SLCs) family in nutrient metabolism and ferroptosis
Authors: Sun Li-Li , He Hai-Yan , Li Wei , Jin Wei-Lin , Wei Yi-Ju 
Published: September 2024

AbstractFerroptosis is a novel form of programmed cell death caused by damage to lipid membranes due to the accumulation of lipid peroxides in response to various stimuli, such as high levels of iron, oxidative stress, metabolic disturbance, etc. Sugar, lipid, amino acid, and iron metabolism are crucial in regulating ferroptosis. The solute carrier transporters (SLCs) family, known as the “metabolic gating” of cells, is responsible for transporting intracellular nutrients and metabolites. Recent studies have highlighted the significant role of SLCs family members in ferroptosis by controlling the transport of various nutrients. Here, we summarized the function and mechanism of SLCs in ferroptosis regulated by ion, metabolic control of nutrients, and multiple signaling pathways, with a focus on SLC–related transporters that primarily transport five significant components: glucose, amino acid, lipid, trace metal ion, and other ion. Furthermore, the potential clinical applications of targeting SLCs with ferroptosis inducers for various diseases, including tumors, are discussed. Overall, this paper delves into the novel roles of the SLCs family in ferroptosis, aiming to enhance our understanding of the regulatory mechanisms of ferroptosis and identify new therapeutic targets for clinical applications.
Integration of new zircon U–Pb ages with biostratigraphy to establish a high-precision age model of the Miocene Nakayama Formation on Sado Island in Central Japan
Authors: Yoshioka Jumpei , Matsuzaki Kenji M. , Niki Sota , Kuroda Junichiro , Hirata Takafumi 
Published: September 2024

AbstractThe most common age constraint for the diatomaceous sediments is biostratigraphy of siliceous microfossils. Although biostratigraphy is a powerful tool to establish stratigraphy and correlate with sedimentary sequences in other sites, biostratigraphy generally includes uncertainties difficult to evaluate. In this study, we measured zircon U–Pb ages of eight tuff beds intercalated with diatomaceous mudstone of the Nakayama Formation on Sado Island in Central Japan and integrated the U–Pb ages with diatom and radiolarian biostratigraphy, whose ages and errors were re-evaluated by this study, to establish an age model precisely representing the sedimentary age. Two tuff beds in the upper and middle part of the formation offered zircon U–Pb ages of 6.7 ± 0.2 Ma and 10.87 ± 0.07 Ma, which are consistent with biostratigraphy, and provided a good example of effective integration of zircon U–Pb ages with the biostratigraphy. On the other hand, zircon U–Pb ages of the other six tuff beds in the lower part are around 12 Ma and not distinguishable from each other. In addition, older zircon grains in the 6 tuff beds are assembled in the interval from 30 to 20 Ma, which is consistent with the age of the volcanic basement rocks forming most part of Sado Island. Similarities in chemical compositions of glass shards and age distributions of zircon grains indicate that the volcaniclastic components in the tuff beds should originate from single or associated magmatic activities.
Herding and investor sentiment after the cryptocurrency crash: evidence from Twitter and natural language processing
Authors: Cary Michael 
Published: September 2024

AbstractAlthough the 2022 cryptocurrency market crash prompted despair among investors, the rallying cry, “wagmi” (We’re all gonna make it.) emerged among cryptocurrency enthusiasts in the aftermath. Did cryptocurrency enthusiasts respond to this crash differently compared to traditional investors? Using natural language processing techniques applied to Twitter data, this study employed a difference-in-differences method to determine whether the cryptocurrency market crash had a differential effect on investor sentiment toward cryptocurrency enthusiasts relative to more traditional investors. The results indicate that the crash affected investor sentiment among cryptocurrency enthusiastic investors differently from traditional investors. In particular, cryptocurrency enthusiasts’ tweets became more neutral and, surprisingly, less negative. This result appears to be primarily driven by a deliberate, collectivist effort to promote positivity within the cryptocurrency community (“wagmi”). Considering the more nuanced emotional content of tweets, it appears that cryptocurrency enthusiasts expressed less joy and surprise in the aftermath of the cryptocurrency crash than traditional investors. Moreover, cryptocurrency enthusiasts tweeted more frequently after the cryptocurrency crash, with a relative increase in tweet frequency of approximately one tweet per day. An analysis of the specific textual content of tweets provides evidence of herding behavior among cryptocurrency enthusiasts.
Benefits, barriers and recommendations for youth engagement in health research: combining evidence-based and youth perspectives
Authors: Bailey Katherine , Allemang Brooke , Vandermorris Ashley , Munce Sarah , Cleverley Kristin , Chisholm Cassandra , Cohen Eva , Davidson Cedar , El Galad Asil , Leibovich Dahlia , Lowthian Trinity , Pillainayagam Jeanna , Ramesh Harshini , Samson Anna , Senthilnathan Vjura , Siska Paul , Snider Madison , Toulany Alene 
Published: September 2024

Abstract
Background
Youth engagement refers to the collaboration between researchers and youth to produce research. Youth engagement in health research has been shown to inform effective interventions aimed at improving health outcomes. However, limited evidence has identified promising practices to meaningfully engage youth. This synthesis aims to describe youth engagement approaches, frameworks, and barriers, as well as provide both evidence-based and youth-generated recommendations for meaningful engagement.

Main body
This review occurred in two stages: 1) a narrative review of existing literature on youth engagement and 2) a Youth Advisory Council (YAC) to review and supplement findings with their perspectives, experiences, and recommendations. The terms ‘youth engagement’ and ‘health research’ were searched in Google Scholar, PubMed, Web of Science, Scopus, and PsycINFO. Articles and non-peer reviewed research works related to youth engagement in health research were included, reviewed, and summarized. The YAC met with research team members and in separate youth-only forums to complement the narrative review with their perspectives. Types of youth engagement include participation as research participants, advisors, partners, and co-investigators. Barriers to youth engagement were organized into youth- (e.g., time commitments), researcher- (e.g., attitudes towards youth engagement), organizational- (e.g., inadequate infrastructure to support youth engagement), and system-level (e.g., systemic discrimination and exclusion from research). To enhance youth engagement, recommendations focus on preparing and supporting youth by offering flexible communication approaches, mentorship opportunities, diverse and inclusive recruitment, and ensuring youth understand the commitment and benefits involved.

Conclusions
To harness the potential of youth engagement, researchers need to establish an inclusive and enabling environment that fosters collaboration, trust, and valuable contributions from youth. Future research endeavors should prioritize investigating the dynamics of power-sharing between researchers and youth, assessing the impact of youth engagement on young participants, and youth-specific evaluation frameworks.
Using Normalisation Process Theory to explore the contribution of stakeholder workshops to the development and refinement of a complex behavioural intervention: the STAMINA lifestyle intervention
Authors: Reale Sophie , Turner Rebecca R. , Steed Liz , Taylor Steph J. C. , Rosario Derek J. , Bourke Liam , Morrissey Dylan , Innes Aidan Q. , Sutton Eileen 
Published: September 2024

Abstract
Background
The National Institute for Health and Care Excellence (NICE) recommend that men with prostate cancer on androgen deprivation therapy (ADT) are offered twice weekly supervised aerobic and resistance exercise to address side effects of treatment. However, supervised exercise is not routinely offered in standard clinical practice. The STAMINA programme grant for applied research (PGfAR) has been designed to evaluate whether this recommendation can be delivered within standard NHS care. This paper describes how future implementation of NICE recommendations within the NHS was explored during complex intervention development to enable evaluation of a lifestyle intervention.

Methods
Two stakeholder workshops were conducted to explore factors pertinent to future implementation of the STAMINA Lifestyle intervention (SLI). Normalisation Process Theory (NPT) provided the theoretical framework for discussion and analysis. Stakeholder workshop 1 focussed on intervention coherence and buy-in. Stakeholder workshop 2 explored barriers and facilitators for embedding SLI into the context of the NHS, with delivery partner Nuffield Health, in the future.

Results
Workshops were attended by healthcare professionals (n = 16), exercise professionals (n = 17), members of public involved in PPI including patients (n = 12), health psychologists (n = 2), clinical commissioners (n = 4), cancer charities (n = 3), a cancer alliance (n = 1) and health economist (n = 1). Stakeholders agreed that professional training packages should emphasise the uniqueness of the SLI and underpinning theory and evidence (Coherence). To further engagement, the use of STAMINA champions and information about the delivery partner were recommended to enhance confidence and knowledge (Cognitive participation). Furthermore, a simple communication (Collective Action) and progress reporting system (Reflexive Monitoring) was suggested to fit into existing infrastructure within the NHS and community partner.

Conclusions
Application of NPT within two stakeholder workshops enhanced complex intervention development. Context-specific strategies to support implementation of SLI within the context of a trial were proposed, sensed-checked, and considered acceptable. The organisational implications of embedding and sustaining the intervention in preparation for wider NHS roll-out were considered (if proven to be effective) and will be explored in the qualitative component of a process evaluation underpinned by NPT.

Trial registration
(ISRCTN: 46385239). Registered on July 30, 2020.
Weight Loss Differentially Impacts Sex Hormones in Women and Men With Type 2 Diabetes: Look AHEAD Sex Hormone Study
Authors: Bennett Wendy L , He Jiahuan Helen , Michos Erin D , Kalyani Rita R , Clark Jeanne M , Woodward Mark , Syed Nazia , Ma Jianqiao , Everett Allen D , Yang Jun , Graham David , Ellis Greg , Vaidya Dhananjay 
Published: September 2024

Abstract

Background
Despite sex differences in type 2 diabetes (T2D), few studies have examined the role of sex hormones. We sought to assess the impact of weight loss, the cornerstone of T2D management, on sex hormone levels.

Methods
This was an ancillary study to the Look AHEAD (Action for Health In Diabetes) Study [n = 850 postmenopausal females, n = 890 males, with T2D and body mass index (BMI) ≥25 kg/m2]. We measured total testosterone (T), estradiol (E2), and SHBG and calculated bioavailable T (bioT). We examined the effect of the intensive lifestyle intervention (ILI) on hormone changes and whether changes were mediated by waist circumference and sex differences in treatment effect.

Results
The baseline mean age was 60 years with a higher proportion of Black females (21%) vs males (9%) and higher mean BMI in females vs males (36.3 vs 34.8 kg/m2). At year 1 in females, ILI decreased E2 by 15% and bioT by 13% and increased SHBG by 21%. At year 1 in males, ILI did not change E2 levels but increased T by 14% and increased SHBG by 18%. The effect was attenuated over 4 years; there were statistically significant sex differences in treatment effect and change in waist circumference due to ILI at year 1 was a significant mediator of sex hormone changes.

Conclusion
Weight loss in T2D resulted in sex hormone changes, which varied by sex and were mediated by changes in waist circumference. Changes in sex hormones due to weight loss in T2D should be considered in the context of an individual's health risks, including cardiovascular conditions, bone health, menopausal symptoms, and cognitive function.
Alterations in Thyroid Hormones in Obese Patients Are Associated With Body Composition Changes After Bariatric Surgery
Authors: Yan Yu , Chu Xuehui , Wang Jing , Kang Xing , Shan Xiaodong , Yu Hang , Zhang Xiaowen , Sun Xitai 
Published: September 2024

Abstract

Context
This article mainly explored the relationship between body composition and thyroid function in euthyroid obesity through correlation analysis, which showed the significant changes of thyroid function after bariatric surgery notably correlated with changes in body composition.

Objective
This study investigates how metabolic/bariatric surgery (MBS) affects thyroid hormone (TH) levels and TH resistance in obese euthyroid individuals, focusing on their correlation with changes in body composition.

Methods
We included 470 obese individuals and 118 controls for baseline assessment, and 125 obese patients receiving MBS for longitudinal study. Data on body composition and thyroid function were collected. Correlations between baseline and changes in thyroid function and body composition were assessed.

Results
In the obese group, thyrotropin (TSH), free triiodothyronine (fT3) levels, and thyroid feedback quantile-based index (TFQI) were elevated and significantly decreased post MBS, along with visceral fat area (VFA) and body fat percentages, whereas skeletal muscle mass (SMM) percentage increased. Preoperative partial correlation analysis adjusted for age and sex revealed that TSH positively correlated with VFA (r = 0.109; P = .019), body fat percentage (r = 0.114; P = .013), and negatively correlated with SMM percentage (r = −0.104; P = .024). Similar correlations were observed between central TH resistance indices and body composition, but no statistically significant correlations were found in the control group. Post MBS, decreased TSH positively correlated with decreased VFA (r = 0.251; P = .006) and increased SMM percentage (r = 0.233; P = .011). While reductions in VFA and body fat percentage were linked to improved central TH resistance, a decrease in peripheral TH conversion was noted.

Conclusion
MBS significantly affects thyroid function and TH resistance, with notable correlations to changes in body composition.
Infinitely many solutions for an anisotropic differential inclusion on unbounded domains
Authors: Figueiredo Giovany Malcher , Razani Abdolrahman 
Published: September 2024

The problem deals with the anisotropic
p
(
x
)
-Laplacian operator where

p
i

are Lipschitz continuous functions
2
≤

p
i

(
x
)
<
N
for all
x
∈

R

N

and
i
∈
{
1
,
…
,
N
}
. Assume

p
N
o

(
x
)
=

max

1
≤
i
≤
N

p
i

(
x
)
,
a
∈

L
+
1

(

R

N

)
∩

L

N

p
N
o

(
x
)
−
1

(

R

N

)
, $F(x,t)$ is locally Lipschitz in the $t$-variable integrand and $\partial F(x,t)$ is the subdifferential with respect to the $t$-variable in the sense of Clarke. By establishing the existence of infinitely many solutions, we achieve a first result within the anisotropic framework.
Profile of Ocular Trauma in Pediatric Population in a Tertiary Care Hospital
Authors: Samson Rajpal  , Nitin Batra  , Gurvinder Kaur  
Published: September 2024

BACKGROUND
Ocular trauma is the major cause for preventable monocular blindness and visual impairment worldwide. It accounts for 8%-14% of total injuries in the pediatric age group. Various studies have shown its higher incidence in this age group. They have different patterns of ocular injuries than adults and have age specific type of injuries. The number of blind years that a child lives with compared to an adult is far more. Most of the previous studies have been on ocular trauma among the adult population, specifically the factory workers in the city of Ludhiana. Moreover, this study aimed to derive a relation between the time of presentation from the injury and the final visual outcome which has rarely been reported in other studies. Profile of ocular trauma in an area is a dynamic and ever changing trend. Therefore, we proposed to study the profile of ocular trauma in pediatric population presenting to our hospital.
METHODS
A total of 60 patients between the age of 0 to 17 years were included in this study. The study was conducted from 15th December 2020 to 31st May 2022. Complete ocular examination was done at the time of presentation and after management; The best corrected visual acuity was noted at the end of three months.
RESULTS
Among our study subjects 45% belonged to the age group of 11-17 years. A male predominance (68.3%) was noted. For most of the subjects, the duration between time of injury and time of examination was less than 6 hours. The proportion of closed globe type of injury (80%) was significantly higher as compared to open globe (8.3%) and extraocular type of injury (11.7%). At the 3 month follow up, out of the 53 study subjects, 92.45% had good visual outcome (VO), 3.77% had fair VO and 3.77% had poor VO respectively.
CONCLUSIONS
Most of the pediatric ocular trauma may be avoided, which emphasizes the value of health education, adult supervision, and the implementation of suitable interventions to lessen the frequency and severity of trauma. Better visual outcome is expected with a shorter duration between time of injury and time of presentation.