bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression of Metabolic Syndrome Severity During the Menopausal Transition
Authors: Gurka Matthew J. , Vishnu Abhishek , Santen Richard J. , DeBoer Mark D. 
Published: August 2016

Background
After menopause, women exhibit a higher prevalence of the metabolic syndrome (MetS) and higher risk of cardiovascular disease. However, the timing of changes in MetS severity over the menopausal transition and whether these changes differ by racial/ethnic group remain unclear.

Methods and Results

We assessed data from 1470 women from the Atherosclerosis Risk in Communities cohort who experienced transition in menopausal status over 10 years (visits 1–4). We used linear mixed models to evaluate changes by menopausal status (premenopause, perimenopause, and postmenopause) in a MetS severity
Z
‐score and in the individual MetS components. While there were gradual increases in MetS severity over time across menopause stages, black women in particular exhibited more rapid progression in MetS severity during the premenopausal and perimenopausal periods than during the postmenopausal period. In the postmenopausal period (compared with prior periods), white women exhibited unfavorable decreases in high‐density lipoprotein, while black women exhibited favorable alterations in the rate of change for waist circumference, triglycerides, high‐density lipoprotein, and glucose, contributing to the slowed progression of MetS severity. These changes were all observed after adjusting for hormone replacement treatment.

Conclusions
During menopausal transition, women exhibited rapid increases in MetS severity during the premenopausal and perimenopausal periods, with black women having significant reductions in this increase in severity during the postmenopausal period. These data suggest that the higher prevalence of MetS in postmenopausal women may be caused more by changes during the menopausal transition than by postmenopause. These findings may thus have implications regarding the timing of cardiovascular risk relative to menopause.
The FLASH Project: Improving the Tools for Flash Flood Monitoring and Prediction across the United States
Authors: Gourley Jonathan J. , Flamig Zachary L. , Vergara Humberto , Kirstetter Pierre-Emmanuel , Clark Robert A. , Argyle Elizabeth , Arthur Ami , Martinaitis Steven , Terti Galateia , Erlingis Jessica M. , Hong Yang , Howard Kenneth W. 
Published: August 2016

Abstract
This study introduces the Flooded Locations and Simulated Hydrographs (FLASH) project. FLASH is the first system to generate a suite of hydrometeorological products at flash flood scale in real-time across the conterminous United States, including rainfall average recurrence intervals, ratios of rainfall to flash flood guidance, and distributed hydrologic model–based discharge forecasts. The key aspects of the system are 1) precipitation forcing from the National Severe Storms Laboratory (NSSL)’s Multi-Radar Multi-Sensor (MRMS) system, 2) a computationally efficient distributed hydrologic modeling framework with sufficient representation of physical processes for flood prediction, 3) capability to provide forecasts at all grid points covered by radars without the requirement of model calibration, and 4) an open-access development platform, product display, and verification system for testing new ideas in a real-time demonstration environment and for fostering collaborations.
This study assesses the FLASH system’s ability to accurately simulate unit peak discharges over a 7-yr period in 1,643 unregulated gauged basins. The evaluation indicates that FLASH’s unit peak discharges had a linear and rank correlation of 0.64 and 0.79, respectively, and that the timing of the peak discharges has errors less than 2 h. The critical success index with FLASH was 0.38 for flood events that exceeded action stage. FLASH performance is demonstrated and evaluated for case studies, including the 2013 deadly flash flood case in Oklahoma City, Oklahoma, and the 2015 event in Houston, Texas—both of which occurred on Memorial Day weekends.
Seasonal Forecasts of Major Hurricanes and Landfalling Tropical Cyclones using a High-Resolution GFDL Coupled Climate Model
Authors: Murakami Hiroyuki , Vecchi Gabriel A. , Villarini Gabriele , Delworth Thomas L. , Gudgel Richard , Underwood Seth , Yang Xiaosong , Zhang Wei , Lin Shian-Jiann 
Published: August 2016

Abstract
Skillful seasonal forecasting of tropical cyclone (TC; wind speed ≥17.5 m s−1) activity is challenging, even more so when the focus is on major hurricanes (wind speed ≥49.4 m s−1), the most intense hurricanes (category 4 and 5; wind speed ≥58.1 m s–1), and landfalling TCs. This study shows that a 25-km-resolution global climate model [High-Resolution Forecast-Oriented Low Ocean Resolution (FLOR) model (HiFLOR)] developed at the Geophysical Fluid Dynamics Laboratory (GFDL) has improved skill in predicting the frequencies of major hurricanes and category 4 and 5 hurricanes in the North Atlantic as well as landfalling TCs over the United States and Caribbean islands a few months in advance, relative to its 50-km-resolution predecessor climate model (FLOR). HiFLOR also shows significant skill in predicting category 4 and 5 hurricanes in the western North Pacific and eastern North Pacific, while both models show comparable skills in predicting basin-total and landfalling TC frequency in the basins. The improved skillful forecasts of basin-total TCs, major hurricanes, and category 4 and 5 hurricane activity in the North Atlantic by HiFLOR are obtained mainly by improved representation of the TCs and their response to climate from the increased horizontal resolution rather than by improvements in large-scale parameters.
Intraseasonal Variability of SST and Precipitation in the Arabian Sea during the Indian Summer Monsoon: Impact of Ocean Mixed Layer Depth
Authors: Li Yuanlong , Han Weiqing , Wang Wanqiu , Ravichandran M. 
Published: August 2016

Abstract
This study investigates sea surface temperature (SST) and precipitation variations in the eastern Arabian Sea (EAS) induced by the northward-propagating Indian summer monsoon (ISM) intraseasonal oscillations (MISOs) through analyzing satellite observations and the Climate Forecast System Reanalysis (CFSR) and performing ocean general circulation model (OGCM) experiments. MISOs in the EAS achieve the largest intensity in the developing stage (May–June) of the ISM. The MISOs induce intraseasonal SST variability primarily through surface heat flux forcing, contributed by both shortwave radiation and turbulent heat flux, and secondarily through mixed layer entrainment. The shallow mixed layer depth (MLD &lt; 40 m) in the developing stage and decaying stage (September–October) of the ISM significantly amplifies the heat flux forcing effect on SST and causes large intraseasonal SST variability. Meanwhile, the high SST (&gt;29°C) in the developing stage leads to enhanced response of MISO convection to SST anomaly. It means that the ocean state of the EAS region during the developing stage favors active two-way air–sea interaction and the formation of the strong first-pulse MISO event. These results provide compelling evidence for the vital role played by the ocean in the MISO mechanisms and have implications for understanding and forecasting the ISM onset. Compared to satellite observation, MISOs in CFSR data have weaker SST variability by ~50% and biased SST–precipitation relation. Reducing these biases in CFSR, which provides initial conditions of the National Centers for Environmental Prediction (NCEP) Climate Forecast System version 2 (CFSv2), may help improve the ISM rainfall forecast.
A Stratified Sampling Approach for Improved Sampling from a Calibrated Ensemble Forecast Distribution
Authors: Hu Yiming , Schmeits Maurice J. , Jan van Andel Schalk , Verkade Jan S. , Xu Min , Solomatine Dimitri P. , Liang Zhongmin 
Published: August 2016

Abstract
Before using the Schaake shuffle or empirical copula coupling (ECC) to reconstruct the dependence structure for postprocessed ensemble meteorological forecasts, a necessary step is to sample discrete samples from each postprocessed continuous probability density function (pdf), which is the focus of this paper. In addition to the equidistance quantiles (EQ) and independent random (IR) sampling methods commonly used at present, the stratified sampling (SS) method is proposed. The performance of the three sampling methods is compared using calibrated GFS ensemble precipitation reforecasts over the Xixian basin in China. The ensemble reforecasts are first calibrated using heteroscedastic extended logistic regression (HELR), and then the three sampling methods are used to sample calibrated pdfs with a varying number of discrete samples. Finally, the effect of the sampling method on the reconstruction of ensemble members with preserved space dependence structure is analyzed by using EQ, IR, and SS in ECC for reconstructing postprocessed ensemble members for four stations in the Xixian basin. There are three main results. 1) The HELR model has a significant improvement over the raw ensemble forecast. It clearly improves the mean and dispersion of the predictive distribution. 2) Compared to EQ and IR, SS can better cover the tails of the calibrated pdfs and a better dispersion of calibrated ensemble forecasts is obtained. In terms of probabilistic verification metrics like the ranked probability skill score (RPSS), SS is slightly better than EQ and clearly better than IR, while in terms of the deterministic verification metric, root-mean-square error, EQ is slightly better than SS. 3) ECC-SS, ECC-EQ, and ECC-IR all calibrate the raw ensemble forecast, but ECC-SS shows a better dispersion than ECC-EQ and ECC-IR in this study.
Intensification of Upper-Ocean Submesoscale Turbulence through Charney Baroclinic Instability
Authors: Capet Xavier , Roullet Guillaume , Klein Patrice , Maze Guillaume 
Published: August 2016

AbstractThis study focuses on the description of an oceanic variant of the Charney baroclinic instability, arising from the joint presence of (i) an equatorward buoyancy gradient that extends from the surface into the ocean interior and (ii) reduced subsurface stratification, for example, as produced by wintertime convection or subduction. This study analyzes forced dissipative simulations with and without Charney baroclinic instability (C-BCI). In the former, C-BCI strengthens near-surface frontal activity with important consequences in terms of turbulent statistics: increased variance of vertical vorticity and velocity and increased vertical turbulent fluxes. Energetic consequences are explored. Despite the atypical enhancement of submesoscale activity in the simulation subjected to C-BCI, and contrary to several recent studies, the downscale energy flux at the submesoscale en route to dissipation remains modest in the flow energetic equilibration. In particular, it is modest vis à vis the global energy input to the system, the eddy kinetic energy input through conversion of available potential energy, and the classical inverse cascade of kinetic energy. Linear stability analysis suggests that the southern flank of the Gulf Stream may be conducive to oceanic Charney baroclinic instability in spring, following mode water formation and upper-ocean destratification.
Pesticide-Related Hospitalizations Among Children and Teenagers in Texas, 2004–2013
Authors: Trueblood Amber B. , Shipp Eva , Han Daikwon , Ross Jennifer , Cizmas Leslie H. 
Published: August 2016

Objective. Acute exposure to pesticides is associated with nausea, headaches, rashes, eye irritation, seizures, and, in severe cases, death. We characterized pesticide-related hospitalizations in Texas among children and teenagers for 2004–2013 to characterize exposures in this population, which is less well understood than pesticide exposure among adults. Methods. We abstracted information on pesticide-related hospitalizations from hospitalization data using pesticide-related International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes and E-codes. We calculated the prevalence of pesticide-related hospitalizations among children and teenagers aged ≤19 years for all hospitalizations, unintentional exposures, intentional exposures, pesticide classifications, and illness severity. We also calculated age- and sex-specific prevalence of pesticide-related hospitalizations among children. Results. The prevalence of pesticide-related hospitalizations among children and teenagers was 2.1 per 100,000 population. The prevalence of pesticide-related hospitalizations per 100,000 population was 2.7 for boys and 1.5 for girls. The age-specific prevalence per 100,000 population was 5.3 for children aged 0–4 years, 0.3 for children and teenagers aged 5–14 years, and 2.3 for teenagers aged 15–19 years. Children aged 0–4 years had the highest prevalence of unintentional exposures, whereas teenagers aged 15–19 years had the highest prevalence of intentional exposures. Commonly reported pesticide categories were organophosphates/carbamates, disinfectants, rodenticides, and other pesticides (e.g., pyrethrins, pyrethroids). Of the 158 pesticide-related hospitalizations, most were coded as having minor ( n=86) or moderate ( n=40) illness severity. Conclusion. Characterizing the prevalence of pesticide-related hospitalizations among children and teenagers leads to a better understanding of the burden of pesticide exposures, including the type of pesticides used and the severity of potential health effects. This study found differences in the frequency of pesticide-related hospitalizations by sex, age, and intent (e.g., unintentional vs. intentional).
The Use of E-Cigarettes Among U.S. Immigrants: The 2014 National Health Interview Survey
Authors: Wang Yang , Wilson Fernando A. , Larson Jamie , Chen Li-Wu 
Published: August 2016

Objective. Although e-cigarette popularity has increased substantially in recent years in the United States, it is unclear whether e-cigarette use has extended to immigrants in the United States. We characterized differences in ever and current use of e-cigarettes among non-U.S. citizens, naturalized U.S. citizens, and U.S. natives. Methods. We used cross-sectional data from the 2014 National Health Interview Survey to measure the prevalence of e-cigarette ever and current use by immigration status, characterized as U.S. native, naturalized U.S. citizen, and non-U.S. citizen. We used multivariate logistic regression to examine the association between e-cigarette use and immigration status adjusting for demographic characteristics, socioeconomic status, and history of tobacco use. We also stratified the use of e-cigarettes by cigarette smoking status and analyzed the impact of length of residency and country of origin on e-cigarette use among immigrants. Results. Naturalized U.S. citizens and non-U.S. citizens had a similar prevalence of e-cigarette use, which was significantly lower than the prevalence among U.S. natives. After adjusting for covariates, naturalized U.S. citizens had 38% lower odds and non-U.S. citizens had 54% lower odds of ever using e-cigarettes than U.S. natives. Non-U.S. citizens were less likely than U.S. natives to currently use e-cigarettes. Among both current smokers and nonsmokers of tobacco cigarettes, non-U.S. citizens were less likely than U.S. natives to indicate current e-cigarette use. U.S. immigrants with >5 years residency were more likely than U.S. immigrants with <5 years residency to try e-cigarettes. Conclusion. Although non-U.S. citizens are less likely than U.S. natives to currently use e-cigarettes, e-cigarette use may increase with length of residency in the United States.
Incidence and Risk for Mood and Anxiety Disorders in a Representative Sample of Ohio Army National Guard Members, 2008–2012
Authors: Fink David S. , Chen Qixuan , Liu Yutao , Tamburrino Marijo B. , Liberzon Israel , Shirley Edwin , Fine Thomas , Cohen Gregory H. , Galea Sandro , Calabrese Joseph R. 
Published: August 2016

Objective. We investigated the incidence of first-onset psychiatric disorders among Ohio Army National Guard members and the sociodemographic and military factors associated with these incident disorders. We aimed to identify potential risk factors and mitigating factors for a range of psychiatric disorders in a representative military sample. Methods. We analyzed data on a representative sample of 528 Ohio Army National Guard members who were assessed in person annually for first-onset psychiatric disorders from 2008 through 2012 using structured clinical interviews. We used a multivariable discrete-time Cox proportional hazard model to determine risk factors of first-onset anxiety or mood disorders. Results. The annualized incidence rate of any first-onset psychiatric disorder was 9.8 per 100 person-years at risk. Alcohol use disorder and major depressive disorder had the highest incidence rates among the unique disorders under study (5.0 and 4.2 per 100 person-years at risk, respectively). We found an association between respondents endorsing past-year deployment and a 29% increase in the risk of incident anxiety or mood disorder, whereas the past-year experience of any non-deployment traumatic event was associated with a 32% increase in risk of incident anxiety or mood disorder. Conclusion. Soldiers experience a substantial burden of first-onset alcohol use disorder and major depressive disorder annually; the experience of non-deployment–related traumatic events contributes substantially to increasing risk, suggesting that any effort aimed at mitigating mood and anxiety disorders in this population must consider the soldier’s life experience and military experience.
A boy with bilateral SUNA: A case report
Authors: Vuković Cvetković Vlasta , Jensen Rigmor Højland 
Published: August 2016

Background Short-lasting unilateral neuralgiform headache attacks (SUNA) is a primary headache characterized by frequent attacks of severe headaches in association with ipsilateral cranial autonomic features. SUNA is defined as a strictly unilateral pain and bilateral cases are very unusual, so secondary causes should be searched for vigorously if there are bilateral symptoms. Despite a number of therapeutic trials, effective management for the majority of SUNA patients is not available at present. Management of SUNA is often difficult. Case We report the case of a young boy with bilateral SUNA attacks, with no detected underlying cause, who is responsive to indomethacin. Conclusion Rarely, primary SUNA can present with bilateral symptoms. According to our experience in this case, indomethacin should always be offered to patients with suspected SUNA.
Early History of the Fields of Practice of Training and Development and Organization Development
Authors: Torraco Richard J. 
Published: August 2016

The Problem While the time and place of the birth of the Academy of Human Resource Development are documented, the field of human resource development (HRD) has historical roots that began decades earlier with the emergence of training and development and organization development as fields of practice. The Solution This article addresses the early history of training and development and organization development, and begins with the influence of World War II on work-related education and training and ends in the mid-1990s. It traces the origins of the field up to, but not including, the founding of the Academy of Human Resource Development in 1994. The historical development of training and development and organization development is shown to be a confluence of historical events and the intellectual contributions of seminal thinkers. The Stakeholders Stakeholders for this article are researchers, practitioners, and others interested in the history of training and development and organization development.
Rivaroxaban for secondary stroke prevention in patients with embolic strokes of undetermined source: Design of the NAVIGATE ESUS randomized trial
Authors: Hart Robert G , Sharma Mukul , Mundl Hardi , Shoamanesh Ashkan , Kasner Scott E , Berkowitz Scott D , Pare Guillaume , Kirsch Bodo , Pogue Janice , Pater Calin , Peters Gary , Davalos Antoni , Lang Wilfried , Wang Yongjun , Wang Yilong , Cunha Luis , Eckstein Jens , Tatlisumak Turgut , Shamalov Nikolay , Mikulik Robert , Lavados Pablo , Hankey Graeme J , Czlonkowska Anna , Toni Danilo , Ameriso Sebastian F , Gagliardi Rubens J , Amarenco Pierre , Bereczki Daniel , Uchiyama Shinichiro , Lindgren Arne , Endres Matthias , Brouns Raf , Yoon Byung-Woo , Ntaios George , Veltkamp Roland , Muir Keith W , Ozturk Serefnur , Arauz Antonio , Bornstein Natan , Bryer Alan , O’Donnell Martin J , Weitz Jeffrey , Peacock Frank , Themeles Ellison , Connolly Stuart J 
Published: August 2016

Background Embolic strokes of undetermined source comprise up to 20% of ischemic strokes. The stroke recurrence rate is substantial with aspirin, widely used for secondary prevention. The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source international trial will compare the efficacy and safety of rivaroxaban, an oral factor Xa inhibitor, versus aspirin for secondary prevention in patients with recent embolic strokes of undetermined source. Main hypothesis In patients with recent embolic strokes of undetermined source, rivaroxaban 15 mg once daily will reduce the risk of recurrent stroke (both ischemic and hemorrhagic) and systemic embolism (primary efficacy outcome) compared with aspirin 100 mg once daily. Design Double-blind, randomized trial in patients with embolic strokes of undetermined source, defined as nonlacunar cryptogenic ischemic stroke, enrolled between seven days and six months from the qualifying stroke. The planned sample size of 7000 participants will be recruited from approximately 480 sites in 31 countries between 2014 and 2017 and followed for a mean of about two years until at least 450 primary efficacy outcome events have occurred. The primary safety outcome is major bleeding. Two substudies assess (1) the relative effect of treatments on MRI-determined covert brain infarcts and (2) the biological underpinnings of embolic strokes of undetermined source using genomic and biomarker approaches. Summary The New Approach riVaroxaban Inhibition of Factor Xa in a Global trial versus ASA to prevenT Embolism in Embolic Stroke of Undetermined Source trial is evaluating the benefits and risks of rivaroxaban for secondary stroke prevention in embolic strokes of undetermined source patients. Main results are anticipated in 2018.
Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression
Authors: Belle Ludovic , Agle Kimberle , Zhou Vivian , Yin-Yuan Cheng , Komorowski Richard , Eastwood Daniel , Logan Brent , Sun Jie , Ghilardi Nico , Cua Daniel , Williams Calvin B. , Gaignage Melanie , Marillier Reece , van Snick Jacques , Drobyski William R. 
Published: August 2016

Key PointsBlockade of IL-27 signaling mitigates the severity of GVHD by recalibrating the effector and regulatory arms of the immune system. Inhibition of IL-27 augments the reconstitution of CD4+ and CD8+ regulatory T cells and increases the stability of Foxp3 expression.