bluuebunny/crossref_metadata_2025_split huggingface dataset:
JIVANEEYAM – Workshop on collection of basic information for the preparation of integrative management protocol for cancer
Authors: Huddar V. G. , Ghildayal Shivani , Tripathi Richa , Nesari Tanuja Manoj 
Published: September 2024

Abstract
Jivaneeyam 2020, a 2-day workshop, was organized on February 10 and 11, 2020, by the Center for Integrative Oncology, All India Institute of Ayurveda, New Delhi. The workshop aimed to collect basic information and prepare an integrative management protocol for cancer. The event was sponsored by the Information, Education, and Communication Department of the Ministry of Ayush, Government of India, New Delhi. The main objective of the workshop was to facilitate a dialog between experts from modern and Ayurvedic medicine on the collection of basic information and treatment protocols for various types of cancer. The results of this dialog will help to prepare an integrative protocol for different cancerous conditions and ultimately reduce the global burden of the disease.
Potential of Ayurveda remedies to manage the pituitary microadenoma – An experience
Authors: Varsakiya Jitendrakumar Nathabhai , Irshad Nazia , Tiwari Rachana , Kathad Divyarani , Ravi Arun Kumar 
Published: September 2024

Abstract
Pituitary adenomas are the most common type of pituitary disorder. They are benign neoplasms that account for 10%–15% of all intracranial masses. Pituitary adenomas are usually nonmalignant, but have a heavy burden on patients and health-care systems. Increased availability of magnetic resonance imaging has led to an increase in incidentally found pituitary lesions and clinically relevant pituitary adenomas. Pituitary adenomas present clinically in three ways: syndromes of hormone hypersecretion or deficiency; neurologic manifestations from mass effect of an expanding gland; or an incidental finding on imaging done for an unrelated issue. Nonfunctioning microadenomas and microprolactinomas in asymptomatic patients do not require immediate treatment. However, a small percentage of these tumors will increase in size or cause new pituitary dysfunction and therefore warrant monitoring. In Ayurveda, it can be correlated with Granthi (tumor). In this case report, a 40-year-old female presented to the outpatient department of Kayachikitsa at Ch. Brahm Prakash Ayurved Charak Sansthan with complaints of severe headache, loss of consciousness over the past year, and double vision persisting for two years. The patient had previously been diagnosed with a pituitary microadenoma. Treatment involved a combination of Pathyadi and Varunadi Kwath, administered as 40 mL on an empty stomach in the morning and evening. Additionally, Kanchnaar Guggulu was prescribed at 500 mg twice daily after meals, Triphala Churna at 5 grams once daily before meals, and Aarogya Vardhini Vati at 250 mg twice daily after meals. Vamana and Virechan Karma are also done, and after that, Takra Dhara and Nasya Karma are also given to the patient. The outcome was assessed on the basis of symptoms and laboratory investigations showed profound results. Therefore, it can be said that these medications are quite successful in treating jaundice.
Epidemiology study on the prognostic factors of intradural extramedullary spinal tumors
Authors: Phankhongsab Anuchit , Sopchokchai Intouch , Piromchai Patorn 
Published: September 2024

ABSTRACT

Introduction:
Intradural extramedullary (IDEM) tumors are rare tumors of the spinal cord. Currently, there is no evidence on the factors that predict poor outcomes in the patients. The objective of this study was to determine the prognostic factors that are associated with poor outcomes in IDEM tumors.

Materials and Methods:
Patients 18 years and older with IDEM tumors who underwent surgery at our institute were identified and retrospectively reviewed. The patient’s demographic data, risk factors, and modified McCormick Scale score were collected.

Results:
A total of 129 patients with IDEM were included in this study. The age ranged from 19 to 79 years (mean 51.3 years), with a predominantly female population (85 patients, 65.9%). Eighty-nine (68.9%) patients had a good outcome, while 40 (31.0%) patients had a poor outcome. The significant factors for poor outcomes included the number of vertebral levels removed for tumor access (adjusted odds ratio [OR] = 3.80, 95% confidence interval [CI] =1.30–11.08, P = 0.013); pathology other than meningioma, schwannoma, and neurofibroma (adjusted OR = 18.86, 95% CI = 2.16–164.49, P = 0.007); and bowel/bladder involvement (adjusted OR = 3.47, 95% CI = 1.15–10.39, P = 0.027).

Conclusion:
We found that the factors for poor outcomes included bowel/bladder involvement, number of vertebral levels removed for tumor access, and pathology other than meningioma, schwannoma, and neurofibroma.
Basal Ganglia Calcification Due to Mineralizing Lenticulostriate Vasculopathy in Children Without Stroke Presentation
Authors: Goraya Jatinder S. , Ghotra Gagandeep S. , Sodhi Amita 
Published: September 2024

Abstract

Background:
Basal ganglia calcification due to mineralizing lenticulostriate vasculopathy has recently been recognized in infants and young children presenting with basal ganglia stroke after minor head trauma. There is little information regarding its occurrence in children outside stroke presentation.

Materials and Methods:
This study is a retrospective chart review of children with basal ganglia calcification due to mineralizing lenticulostriate vasculopathy but with non-stroke presentation.

Results:
Fifteen children, 11 boys, and 4 girls, aged from 3 months to 16 years met the inclusion criteria. Five children were under 2 years of age, 6 between 2.5 and 9 years, and 4 between 10 and 16 years. Seven children presented with seizures including three each with febrile seizures, epilepsy, and one with hypocalcemic seizures. Three children had migraine, one syncope, and one head-rolling. One child each presented with attention-deficit hyperactivity disorder, developmental delay, and minor head trauma. Basal ganglia calcification was punctate and asymmetric on axial computed tomography images in all the children. Coronal and sagittal reconstruction images were available in four children, and all showed linear hyperdensities in the basal ganglia conforming to the calcification of lenticulostriate arteries. The calcification was bilateral in 11 and unilateral in 4. All except one child had normal development.

Conclusion:
Basal ganglia calcification due to mineralizing lenticulostriate vasculopathy can be observed in children without presentation with stroke. Affected children tend to be older than those with stroke presentation. The association is likely incidental, but further studies are needed to better delineate this entity.
Discoid Meniscus – A Review of Literature and Our Case Series
Authors: Reddy G. Swetha , Nekkanti Madhava Rao , Adla Deepthi Nandan Reddy , Venuthurla Ram Mohan Reddy , Bhan Nitish 
Published: September 2024

Abstract

Aim:
The current study aims at the surgical outcome of the lateral discoid meniscus which is treated with knee arthroscopy, meniscal refashioning, and meniscal repair in various age groups.

Materials and Methods:
The study includes 7 patients (3 females and 4 males) with a mean age of 26.6 (Range 10 to 50 years). This is a retrospective type of study with a study period ranging from June 2018 to January 2024.

Results:
Patient satisfaction was excellent in all cases regarding pain, locking of the knee, Range of motion, and return to sports/daily activities. Diagnostic Arthroscopy confirmed the discoid meniscus abnormality in all the cases. Bucket handle type tear of the lateral menisci in 2 cases. Anterior horn tear in 1 case. Horizontal tear in 1 case. Unstable discoid meniscus in 3 cases. Meniscoplasty, removal of central part of meniscus, and sparing its periphery was done for all cases. Stabilization of the meniscus was done with meniscal repair in 4 patients with inside-out and all inside techniques. Visual analog score (VAS score) has significantly reduced from moderate pain (45-74)and mild pain (5-44 mm)to no pain (0-4 mm).

Conclusion:
Arthroscopic sauscerization, meniscoplasty alone, or additional stabilization with meniscal repair can provide excellent clinical outcomes in patients with symptomatic lateral discoid meniscus.
Management of Aseptic Both Bone Forearm Diaphyseal Gap Nonunion
Authors: Deepthi Sabavath , Rao V. Sahetya Mohan , Vishwanath M. , Srikanth S. 
Published: September 2024

Abstract
Aseptic nonunions of both bone forearm fractures present significant challenges in treatment, often requiring specialized surgical intervention. This case report provides an overview of the prevalence, etiology, and surgical considerations in managing such nonunions. This case report presents a 51 year old male with both bone forearm diaphyseal nonunion following a road traffic accident, managed with iliac crest and nonvascularized fibular bone grafting. Surgical intervention involved debridement, gap bridging with fibular strut graft, and stabilization with plate. Aseptic both bone forearm nonunions disrupt mechanics, leading to functional impairment. Surgical management aims at maintaining radial length, joint function, and avoiding positive ulnar variance. Treatment involves debridement, alignment correction, bone grafting, and may include vascularized fibular grafting or the Ilizarov method, while nonvascularized fibula strut grafts provide a favorable alternative with low complication rates. The case report demonstrates successful management of aseptic both bone forearm diaphyseal nonunion using nonvascularized fibular strut graft, resulting in excellent functional outcomes without complications. The efficacy and feasibility of this treatment approach in achieving union and restoring forearm function is highlighted.
Current Concepts and Management Strategies in Cervical Spondylotic Myelopathy
Authors: Arjun K. , Yelamarthy P. K. Karthik , Narayan T. V. Krishna , Kathare Ambadas , Mulukutla Raghav Dutt 
Published: September 2024

Abstract
Early diagnosis and treatment of cervical spondylotic myelopathy (CSM) are critical to achieve satisfactory results and successful functional outcomes for the patients. Usually, such patients present late, resulting in unsatisfactory treatment outcomes. It is not uncommon to see clinicians failing to recognize the early symptoms there by resulting in delayed referrals to spine surgeons. The objective of this review is to highlight the salient clinical features, pathogenesis, and management options for CSM. The epidemiology, applied anatomy, and pathogenesis of CSM are discussed, along with a review of current literature regarding the management of CSM. A thorough evaluation needs to be done to rule out medical causes for myelopathy and other neurological conditions which mimic CSM. Those with mild CSM with minimal symptoms need to be observed carefully at regular intervals. Early intervention in patients with moderate-to-severe CSM is superior to conservative treatment. Surgical strategies include anterior, posterior, or combined approaches. A thorough decompression of the spinal cord and roots and restoration of cervical lordosis should be the primary goal of the operating surgeon. Needless to mention high quality postoperative rehabilitation and exercise programs go a long way in achieving satisfactory results after surgery.
Endoscopic vacuum assisted closure therapy for esophagopericardial fistula in a 16-year-old male: A case report
Authors: Muñoz-González Simón , Quejada-Cuesta Samir , González-Arroyave Daniel , Ardila Carlos M 
Published: September 2024

BACKGROUND
Esophagopericardial fistula (EPF) is a rare, life-threatening condition with limited scientific literature and no established management guidelines. This case report highlights a successful multidisciplinary approach and the innovative use of endoscopic vacuum assisted closure (endoVAC) therapy in treating this complex condition.
CASE SUMMARY
A 16-year-old male with a history of esophageal atresia and colon interposition presented with progressive chest pain, fever, and dyspnea. Imaging revealed an EPF with associated pleural and pericardial effusions. Initial management with an esophageal stent failed, prompting the use of an endoVAC system. The patient underwent multiple endoVAC device changes and received broad-spectrum antibiotics and nutritional support. The fistula successfully closed, and the patient recovered, demonstrating no new symptoms at a 6-month follow-up.
CONCLUSION
EndoVAC therapy can effectively manage EPF, providing a minimally invasive treatment option.
Exploring Production Constraints, Varietal Traits Preferences and Factors Influencing Adoption of Improved Rice Varieties in Nobewam, Ashanti Region
Authors: Acheampong P.P. , Dartey P.K. 
Published: September 2024

Identifying appropriate policy interventions to improve rice productivity is crucial to improvingn food security and incomes. This study used data from 73 rice farmers randomly selected from an irrigated scheme and employed Kendall's Coefficient of Concordance and multivariate regression techniques to explore production constraints, farmers' subjective varietal traits preferences and factors affecting adoption of improved rice varieties. Results showed capital acquisition, drudgery in land preparation, and weed infestation were among the constraints to rice production. Also, farmers selected rice varieties based on taste, ease of cooking, milling recovery, swelling ability and aroma. Empirical results revealed that farm size, land tenure, ease of cooking, milling recovery and percentage broken affected the selection of improved rice varieties. We suggest that rice varietal development programmes should consider grain traits preferred by end users in breeding activities. Also, government and local authorities should guarantee land tenure security across rice production areas to encourage the adoption of improved varieties.
Seroprevalence and related risk factors of Hepatitis E virus infection among pregnant women attendees at Adeoye Hospital, Ibadan, Nigeria
Authors: Ike W. E. , Oduleye A. O. , Ariom T. O. , Igbokwe C. O. , Ike A. J. , Okiye J. A. 
Published: September 2024

Hepatitis E virus (HEV) is a major public health problem in developing countries and often fatal among pregnant women. This study investigated the seroprevalence and risk factors of HEV infection in pregnant patients at Adeoyo General Hospital in Ibadan, Nigeria. The cross-sectional study was carried out from January 15, 2022 to September 30, 2022. An enzyme linked immunosorbent assay (ELISA) kit was used to assess the levels of anti- HEV IgM and IgG in 210 blood samples from pregnant women who gave their consent and joined the study. Utilizing structured questionnaires, the risk variables and sociodemographic characteristics were assessed. Out of the 210 pregnant women sampled, anti-HEV IgM/IgG seroprevalence of (1.9%/2.9%) were recorded respectively. The seroprevalence was greater (4.0%/8.0%) in the age group of 35 to 39 years and zero in age ranges 15 – 19, and >40 years. The highest prevalence for anti-HEV IgM was recorded among primary school subject (12.5%), followed by secondary (1.9%), and 4.1% among tertiary subject for anti-HEV IgG. After logistic regression, marital status, and occupation were found not to be significant risk factors for active HEV infection (p>0.05). This study found a considerably low level of anti-HEV IgM seropositivity among pregnant women in the study group, which is indicative of emerging and non-active HEV infection. This is based on the 10.8% pooled national prevalence of HEV infection in Nigeria.
Effect of lipoic acid combination with valsartan on diabetic nephropathy and associated adverse reactions
Authors: Wang Minqin , Luo Jiaying , Xue Jisu 
Published: September 2024

Purpose: To investigate the effect of lipoic acid combination with valsartan on diabetic nephropathy (DN) and its associated adverse reactions.
Methods: A retrospective analysis was conducted on 120 patients who treated for DN at the Second Affiliated Hospital of Shenzhen University, China between August 2019 and October 2022. Based on different treatment approaches, control group comprised 55 patients receiving valsartan alone, while joint group consisted of 65 patients receiving a combination of valsartan and lipoic acid. Therapeutic effectiveness and adverse events were compared between the groups. Additionally, changes in blood glucose and renal function parameters were evaluated pre- and post-treatment.
Results: Post-treatment, both groups exhibited improvements in blood glucose and renal function parameters compared to pre-treatment values (p < 0.05). However, joint group demonstrated superior improvements in these parameters compared to control group (p < 0.05). Total efficacy was significantly higher in the joint group than in control group (p < 0.05). No significant differences were observed between the groups' incidence of adverse reactions (p > 0.05).
Conclusion: Concurrent therapy of lipoic acid and valsartan sly treats DN. It enhances the regulation of blood glucose levels and improves renal function with high safety. Further studies employing larger sample sizes and prospective designs with comprehensive patient follow-up are required to further validate and enhance the reliability of these findings.
Effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants
Authors: Zhang Li-li , Wang Li-li , You Mei , Wei Zi-xuan , Ding Yuan , Han Nan-nan , Kong Yuan-yuan , Wang Xiao-yan , Jin Xiao-li , Li Li , Liu An-nuo 
Published: September 2024

Purpose: To investigate the effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants.
Methods: A total of 151 preterm infants admitted to the Neonatology Department, First Affiliated Hospital of Anhui Medical University, Hefei, China, from November 2020 to June 2021 were selected. Preterm infants were randomly divided into control and study groups. Control group received 2 % povidone-iodine and 75 % ethanol application, followed by gentle pressure with a cotton swab while the study group received amoxicillin-clavulanate potassium applied to the umbilical cord while shaking. The management interventions were stopped after umbilical cord separation in preterm infants, and the difference in umbilical cord separation time between the two groups was compared. Factors associated with preterm birth conditions, hospitalization, and maternal health were identified by univariate and multivariate logistic regression analyses.
Results: The number of cases with umbilical cord separation time > 14 days was significantly higher in the study group compared to control group (p < 0.05). The average umbilical cord separation time in the study group was significantly lower compared to control group (p < 0.05). Univariate analysis revealed that incubator residence time significantly affects umbilical cord separation time in preterm infants (p < 0.05). Logistic multivariate regression analysis identified incubator residence time as the main factor influencing umbilical cord separation time in preterm infants.
Conclusion: The use of amoxicillin-clavulanate potassium shortens umbilical cord separation time, and incubator residence time is the major factor influencing umbilical cord separation in preterm infants. Further studies should expand the study scale and increase the number of samples used.
Effect of ropivacaine concentrations in combined spinalepidural anesthesia on efficacy and sedation levels in lower abdominal obesity patients
Authors: Zhu Yangling , Zheng Xiaoshu 
Published: September 2024

Purpose: To investigate the effect of varying ropivacaine concentrations in combined spinal-epidural anesthesia (CSEA) on anesthetic efficacy and sedation in patients with lower abdominal obesity.
Methods: 110 patients with lower abdominal obesity who received CSEA in Traditional Chinese Medicine Hospital, Lin 'an District, Hangzhou, China from January 2020 to December 2022 were retrospectively enrolled. Patients were divided into a low-concentration group (LC group, n = 49) which received 0.3 % ropivacaine, and a high- concentration group (HC group, n = 61) which received 0.5 % ropivacaine. Changes in visual analogue scale (VAS) scores and Ramsay sedation scale (RSS) scores in both groups were analyzed at 1, 2, 4 and 6 h after surgery.
Results: The LC group showed significantly higher static and dynamic VAS scores than HC group at 1, 2, 4 and 6 h after surgery. Furthermore, HC group demonstrated significantly shorter (p < 0.05) onset times for sensory and motor blocks, longer sensory and motor recovery times, and lower mean arterial pressure (MAP) level 10 min after administration compared to the LC group. However, MAP levels 30 min after administration were similar to baseline levels in both groups (p > 0.05).
Conclusion: High-concentration ropivacaine in CSEA offers superior post-operative analgesia, and improves patient satisfaction without increasing adverse reactions in patients with lower abdominal obesity. Further studies using larger sample size and longer duration of investigation are required to strengthen the validity of these results.
Efficacy of triple therapy inhalers in acute exacerbations of chronic obstructive pulmonary disease
Authors: Wang Weibiao , Teng Hong 
Published: September 2024

Purpose: To evaluate the efficacy of triple inhaled therapy, a combination of inhaled glucocorticoids, long-acting muscarinic antagonists, and long-acting β2 agonists in managing acute exacerbations of chronic obstructive pulmonary disease (COPD).
Methods: Medical data of 100 patients with acute exacerbation of COPD admitted to Shaoxing Second Hospital, Shaoxing, China between January 2020 to December 2022 was collected and retrospectively analyzed. The patients were randomized into control (n = 50) and study groups (n = 50). Control group received budesonide/formoterol inhalers while the study group received triple inhaled therapy (budesonide/glycopyrronium/formoterol inhalers). Arterial blood gas, pulmonary function, immune function, adverse effects, and efficacy were evaluated.
Results: The study group exhibited significantly higher pH, partial pressure of arterial oxygen (PaO2), and lower partial pressure of carbon dioxide (PaCO2) compared to control group (p < 0.001). Furthermore, the study group showed significantly higher levels of pulmonary function and immune function indices compared to control group (p < 0.001). There was no significant difference in incidence of adverse reactions between the two groups (p > 0.05). The study group was associated with higher clinical efficacy compared to the control group (p < 0.05).
Conclusion: Triple inhaled therapy significantly alleviates the clinical symptoms of patients with COPD and enhances pulmonary and immune functions. Future studies should cover a larger and more diverse group of participants for broader validity.