bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors
Authors: Hu Zhe-Xing , Li Yin , Yang Xuan , Li Yu-Xia , He Yao-Yao , Niu Xiao-Hui , Nie Ting-Ting , Guo Xiao-Fang , Yuan Zi-Long 
Published: September 2024

BACKGROUND
The colon cancer prognosis is influenced by multiple factors, including clinical, pathological, and non-biological factors. However, only a few studies have focused on computed tomography (CT) imaging features. Therefore, this study aims to predict the prognosis of patients with colon cancer by combining CT imaging features with clinical and pathological characteristics, and establishes a nomogram to provide critical guidance for the individualized treatment.
AIM
To establish and validate a nomogram to predict the overall survival (OS) of patients with colon cancer.
METHODS
A retrospective analysis was conducted on the survival data of 249 patients with colon cancer confirmed by surgical pathology between January 2017 and December 2021. The patients were randomly divided into training and testing groups at a 1:1 ratio. Univariate and multivariate logistic regression analyses were performed to identify the independent risk factors associated with OS, and a nomogram model was constructed for the training group. Survival curves were calculated using the Kaplan–Meier method. The concordance index (C-index) and calibration curve were used to evaluate the nomogram model in the training and testing groups.
RESULTS
Multivariate logistic regression analysis revealed that lymph node metastasis on CT, perineural invasion, and tumor classification were independent prognostic factors. A nomogram incorporating these variables was constructed, and the C-index of the training and testing groups was 0.804 and 0.692, respectively. The calibration curves demonstrated good consistency between the actual values and predicted probabilities of OS.
CONCLUSION
A nomogram combining CT imaging characteristics and clinicopathological factors exhibited good discrimination and reliability. It can aid clinicians in risk stratification and postoperative monitoring and provide important guidance for the individualized treatment of patients with colon cancer.
Uninvolved liver dose prediction in stereotactic body radiation therapy for liver cancer based on the neural network method
Authors: Zhang Huai-Wen , Wang You-Hua , Hu Bo , Pang Hao-Wen 
Published: September 2024

BACKGROUND
The quality of a radiotherapy plan often depends on the knowledge and expertise of the plan designers.
AIM
To predict the uninvolved liver dose in stereotactic body radiotherapy (SBRT) for liver cancer using a neural network-based method.
METHODS
A total of 114 SBRT plans for liver cancer were used to test the neural network method. Sub-organs of the uninvolved liver were automatically generated. Correlations between the volume of each sub-organ, uninvolved liver dose, and neural network prediction model were established using MATLAB. Of the cases, 70% were selected as the training set, 15% as the validation set, and 15% as the test set. The regression R -value and mean square error (MSE) were used to evaluate the model.
RESULTS
The volume of the uninvolved liver was related to the volume of the corresponding sub-organs. For all sets of R -values of the prediction model, except for Dn0 which was 0.7513, all R -values of Dn10-Dn100 and Dnmean were > 0.8. The MSE of the prediction model was also low.
CONCLUSION
We developed a neural network-based method to predict the uninvolved liver dose in SBRT for liver cancer. It is simple and easy to use and warrants further promotion and application.
Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma
Authors: He Ming , Qi Ye , Zheng Ze-Mao , Sha Min , Zhao Xiang , Chen Yu-Rao , Chen Zheng-Hai , Qian Rong-Yu , Yao Juan , Yang Zheng-Dong 
Published: September 2024

BACKGROUND
The clinical effects and detailed roles of long non-coding RNA (LncRNA) steroid receptor RNA activator 1 (SRA1) in esophageal squamous cell carcinoma (ESCC) remain ambiguous. In the present study, the complementary sites between lncRNA SRA1, miRNA-363-5p, and phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) predicted via bioinformatics analysis stimulated us to hypothesize that miRNA-363-5p/LHPP axis might be required for SRA1-mediated ESCC progression.
AIM
To investigate the molecular events of SRA1 in the malignant behavior in ESCC.
METHODS
Thirty-eight ESCC tissues and paired adjacent normal tissues were acquired. SRA1 expression was detected in ESCC tissues and cell lines using quantitative reverse transcription-polymerase chain reaction. Cell counting Kit-8 assay, transwell invasion assay, glycolysis assay, and xenograft tumor model were performed to address the malignant biological behaviors of ESCC cells after the introduction of SRA1. The t -test and the χ 2 test were used for comparison between groups. Survival curve analysis was performed using the Kaplan-Meier method.
RESULTS
SRA1 downregulation was identified in ESCC. ESCC patients exhibiting a low SRA1 expression faced shorter overall survival than those with a high SRA1 expression. The introduction of SRA1 inhibited cell proliferation, glucose uptake, and lactate production in ESCC. In vivo , the growth of ESCC was hindered by SRA1 overexpression. Then, SRA1 overexpresses the LHPP by inhibiting miRNA-363-5p. Lastly, the introduction of small interfering RNA si-LHPP or miRNA-363-5p mimic could abrogate the inhibition roles triggered by SRA1.
CONCLUSION
SRA1 inhibits the oncogenicity of ESCC via miRNA-363-5p/LHPP axis. The SRA1/miRNA-363-5p/LHPP pathway may be a therapeutic target for ESCC.
Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids: A case report
Authors: He Yong-Gang , Zhang Ling-Yu , Li Jing , Wang Zheng , Zhao Chong-Yu , Zheng Lu , Huang Xiao-Bing 
Published: September 2024

BACKGROUND
Patient-derived organoids (PDOs) have been demonstrated to predict the response to drugs in multiple cancer types. However, it remains unclear about its application in cholangiocarcinoma.
CASE SUMMARY
A 59-year-old woman was admitted to the hospital due to upper abdominal pain for over 8 months. According to relevant examinations, she was diagnosed as perihilar cholangiocarcinoma (pCCA) with intrahepatic metastasis and perihilar lymphatic metastasis. After multidisciplinary team discussion, percutaneous transhepatic cholangiodrainage was performed to relieve biliary obstruction, and puncture biopsy was conducted to confirm the pathological diagnosis. Transarterial chemoembolization with nab-paclitaxel was used in combination with toripalimab and lenvatinib, but the levels of tumor markers including alpha fetal protein, carcinoembryonic antigen, carbohydrate antigen 15-3 and cancer antigen 125 were still raised. The PDO for drug screening showed sensitive to gemcitabine and cisplatin. Accordingly, the chemotherapy regimen was adjusted to gemcitabine and cisplatin in combination with toripalimab and lenvatinib. After 4 cycles of treatment, the tumor was assessed resectable, and radical surgical resection was performed successfully. One year after surgery, the patient was still alive, and no recurrence or occurred.
CONCLUSION
PDOs for drug sensitivity contribute to screening effective chemotherapy drugs for advanced pCCA, promoting conversion therapy and improving the prognosis.
Análisis procesal del divorcio sin expresión de causa durante la pandemia COVID-19 en Baja California, México
Authors: García Yolanda Sosa y Silva 
Published: September 2024

Así como la enfermedad denominada COVID-19 originada por el virus SARS-CoV-2, causó una emergencia sanitaria a nivel mundial, lógico es pensar que las repercusiones también lo fueron. El presente artículo encuentra justificación o importancia en enfatizar el conocimiento del procedimento del divorcio sin expresión de causa durante la pandemia para estar en posibilidades de prevenir si se llegara a presentar otra contigencia similar, reflejando nuestro objetivo que podemos definir como analizar el comportamiento procesal de la institución jurídica denominada divorcio sin expresión de causa. Destacaremos algunos comentarios, tanto del lugar donde inició la enfermedad, como de España, Estados Unidos y México, dejando testimonio que el mayor daño causado fue en la Salud Mental de la población mundial. Posteriormente encuadraremos al Derecho de Familia como Derecho Social y su relación con el Derecho Civil, por lo que es menester relatar algunos de sus antecedentes históricos, hasta ubicarlo en la legislación vigente en Baja California, México. Definiremos el divorcio en general y el sin expresión de causa en particular; todo lo anterior en base a una metodologia descriptiva-normativa de estudio doctrinal y jurisprudencial evolutivo en relación con la concepción del divorcio, partiendo del concepto de dignidad y libre desarrollo de la personalidad en el sistema jurídico mexicano, para posteriormente utilizar la técnica de investigación de campo, con expedientes judiciales cuyos resultados se discuten y enfatizan descubrimientos clave, por lo que podemos extender o concluir con un margen de error mínimo, a todo el orbe, por ser el origen o causa común.
A Vitiation of Pitta Dosha in Sharad Ritu and its Management by Nitya Virechana Dravya
Authors: Bhagyashri A. Chakole  , Deepika Arun chakole  , Anita Choudhary  
Published: September 2024

Pama Kushta is explained in Ayurveda which is outcome of Pitta Dosha Dushti it has similarities with eczema. Eczema is a chronic inflammatory skin condition characterized by redness, itching, and rash, affects a significant portion of the population worldwide. This case report presents the initial successful management of eczema in a patient using Ayurvedic interventions. A 30-year-old female patient presented with persistent eczema symptoms on her arms and legs. The patient underwent a thorough evaluation based on Ayurvedic principles, which identified imbalances in Doshas (bioenergies) according especially in autumn season and suggested a treatment plan accordingly. The interventions included internal medications to alleviate imbalances Pitta Dosha, external application of Marichyadi Oil to soothe the affected areas. After adhering to the treatment plan for two weeks, the patient experienced a significant reduction in eczema symptoms, including reduced redness, itching, and improvement in skin texture. This case report highlights the potential efficacy of Ayurvedic interventions with Siddhanta. The holistic approach of Ayurveda, addressing root cause, resulted in improved symptom control and enhanced quality of life for the patient. While further research is warranted to validate these findings, the present report suggests that Ayurveda could be a valuable complementary approach for individuals struggling with eczema. Health professionals and patients alike may consider exploring Ayurvedic interventions as an adjunct or alternative to conventional eczema management strategies.
Hepatoprotective Activity of Patra Swarasa of Guduchi (Tinospora Cordifolia) Against- Paracetamol Induced
Authors: Yadav Chandra Kishor  , Hegde Prakash L  
Published: September 2024

Guduchi (Tinospora cordifolia (Willd.) Miers], Menispermaceae family, it is important medicinal plant is widely distributed through India. It is categorized as "Rasayana" and the whole plant is used medicinally. The aim of the present study is to evaluate the protective effect of Guduchi patra swaras against paracetamol induced liver damage in Wister albino rats. Material & Methods: Wistar Albino rats (140-250g) will be divided into 6 group and each group 6 rats, into control group, paracetamol control, standard group, test group. The test drug Guduchi patra swarasa was administered orally for 10 consecutive days and two dose of the toxicant (paracetamol) were administered orally to each group, on two alternate days i.e., 7th and 9th day, 1hr after test drug administration. After 48 hours of toxicant paracetamol, and standard group. The blood was collected in EDTA tube and sent for biochemistry laboratory for biochemical investigations. Result: The analysis of serum biochemical parameters shows that administration of paracetamol leads to significant change in majority of the parameters. The overall activity profile indicated reversal of important parameters like SGOT, SGPT, total bilirubin, total protein, blood sugar level, serum globulin, serum albumin, serum total cholesterol and serum triglycerides. All three test groups of Guduchi patra Swarasa administered are found to be effective heapto-protective especially based on histo-pathological study. Among the three groups, the double dose group and therapeutic group has shown good results in comparison with the other two groups. Conclusion: In the present study, the overall activity profile of Guduchi patra Swarasa administered are found to be effective hepatoprotective among the three groups therapeutic double dose shows good results in comparison with the other group.
Exploring the Ayurvedic Concept of Manasa Prakriti in Light of Contemporary Temperament Theory and Personality Disorders
Authors: Bushra Thazneem C S  , Ajitha K  , Ananda Lakshmy K N  
Published: September 2024

Personality pertains to the different patterns of behaviour, cognitive processes, and emotional responses that distinguish individuals. It is composed of three primary components: physiological, psychological, and environmental factors. Personality is referred to as 'Prakriti’ expressing an individual's intrinsic qualities impacted by their genetic physical and mental composition, in the domain of Ayurveda. The predominant Doshas present during conception, as well as those within the womb, ultimately shape a person's Prakriti. The Prakriti constitution signifies the unique equilibrium that exists between the Sharira (body) and the Manas (mind). Manasa Prakriti or the psychic expression or constitution, is the inherent mental disposition resulting from the union of Sukra (semen), Shonita (ovum), and Atma (soul). According to Ayurveda, the relative dominance of the three principal mind components referred to as Trigunas: Satwika (purity), Rajasika (movement), and Tamasika (inertia and dullness), also known as Maha prakriti, shapes a person's psychological constitution. Identifying and encouraging personal development, enhancing interpersonal skills, and nurturing leadership qualities are all benefits of assessing an individual's Manasa prakriti. It also plays an important role in sustaining health and recommending appropriate therapeutic procedures. Furthermore, the prognosis is determined by an individual's Manas Prakriti type. In this review, an attempt is made to explore the Ayurvedic concept of Manasa Prakriti in light of contemporary temperament theory and personality disorders.
The Prevalence of Depressive Symptoms among Adults Living in the UAE during the COVID-19 Pandemic
Authors: Ghalyoun L , Abualhab M , Naji M , Mohammed A , Alsumaiti F , Alshehhi H , Karim A 
Published: September 2024

Purpose: To investigate the prevalence of depressive symptoms among adults living in the UAE during the COVID-19 pandemic.
Methods: This cross-sectional study used a self-administered anonymous online questionnaire distributed in both Arabic and English via social media platforms. A total of 261 adults living in the UAE were included in the study, using a non-probability volunteer sampling. Univariate and bivariate analyses of the acquired data were analyzed using SPPS Statistics version 26. Patients clinically diagnosed with depression were excluded from this study.
Findings: Overall, the prevalence of depression among our studied population was 63%. Several parameters were correlated with depression to assess their associations. A lower household income was found to be linked to a greater likelihood of developing depression, as 74.6% of depressed subjects had an income lower than 20,000 Dhs (p=0.003). Age also had a significant correlation (95% CI, p=0.003) with depression, and those in the younger age group (18-25 years) had a greater prevalence of depression than did those in the older age group. Difficulty performing daily activities, restless sleep, feeling lonely, feeling sad, feeling inadequate, and losing hope were the most commonly reported symptoms in depressed subjects. A total of 78.21% of our participants did not know about hotlines when they were depressed; however, this difference was not statistically significant (95% CI, p=0.178).
Unique Contribution to Theory, Practice and Policy: Depression was prevalent in 63% of our participants. A lower household income and younger age were associated with a greater risk of depression. We believe that our findings will encourage institutions and government authorities to implement awareness programs about depression awareness and screening for depression. Families should support individuals seeking professional help, particularly if their depressive symptoms are severe or persistent.
Uma análise da história da matemática presente em livros didáticos na perspectiva da decolonialidade
Authors: Baluz Leticia , Flores Cláudia Regina , Da Silva Neto Benjamim Cardoso 
Published: September 2024

O presente trabalho tem por objetivo analisar o modo como a História da Matemática tem sido apresentada em uma coleção de livros didáticos a partir de uma perspectiva decolonial. Para isso, escolhemos a coleção de livros Matemática Interligada, do ano 2020, da Editora Scipione, composta de seis volumes, distribuída em escolas públicas do estado do Maranhão. Em nossas discussões, observamos que a presença da História da Matemática é ponto comum e naturalizado, e é frequente que tais eventos estejam associados a matemáticos europeus e suas descobertas, criando a impressão de que todo conhecimento matemático surge a partir de um único indivíduo. No entanto, é fundamental reconhecer que o desenvolvimento da matemática ocorreu em todo o mundo de maneiras diversas, envolvendo tanto homens quanto mulheres, e não se limitou apenas ao contexto europeu.
Making and Unmaking the Carolingians
Authors: Airlie Stuart 
Published: September 2024

How does power manifest itself in individuals? Why do people obey authority? And how does a family, if they are the source of such dominance, convey their superiority and maintain their command in a pre-modern world lacking speedy communications, standing armies and formalised political jurisdiction? Here, Stuart Airlie expertly uses this idea of authority as a lens through which to explore one of the most famous dynasties in medieval Europe: the Carolingians.
Ruling the Frankish realm from 751 to 888, the family of Charlemagne had to be ruthless in asserting their status and adept at creating a discourse of Carolingian legitimacy in order to sustain their supremacy. Through its nuanced analysis of authority, politics and family, Making and Unmaking the Carolingians, 751–888 outlines the system which placed the Carolingian dynasty at the centre of the Frankish world. In doing so, Airlie sheds important new light on both the rise and fall of the Carolingian empire and the nature of power in medieval Europe more generally.
Buprenorphine: Opioid Agonist-Antagonist for Refractory Pain of Sickle Cell Disease Patients During Hematopoietic Stem Cell Transplant, Uncontrolled By Full-Agonist Opioids
Authors: Sakae Mayuko 
Published: September 2024

Background: Bone marrow transplant (BMT) offers potential cure for cancer and a spectrum of otherwise incurable diseases. The BMT process can cause multi-systemic pain in patients with sickle cell disease (SCD) refractory to high-dose opioid analgesics during BMT because of their pre-existing opioid-tolerance. Because of frequent pain resulting in hyperalgesia and chronic opioid use, SCD patients undergoing BMT often experience excruciating pain uncontrolled by exceedingly high-dose opioids with severe and intolerable adverse effects.
Purpose/hypothesis: There is a small but growing body of literature about the successful buprenorphine effect for SCD's chronic pain management that had failed sufficient pain relief by the traditional full-agonist opioids in the outpatient setting. However, the buprenorphine use for acute inpatient pain management has not been previously researched. Pilot prospective clinical trial with buprenorphine-based pain management for acute BMT-related pain was initiated for SCD patients’ pain uncontrolled by full-agonist opioids.
Procedures/data/observations: Buprenorphine was started as scheduled and as-needed analgesics, supplemented by full-agonist opioids upon consultation for uncontrolled BMT-related pain of SCD patients. Patients' 24-hour opioid requirement by morphine equivalent daily doses (MEDD) were assessed at 3 time points: 1)immediately before pain escalation; 2)consultation; 3)discharge. MEDDs were compared to those of patients treated with full-agonist opioids only. Cases treated by full-agonist opioids (morphine/hydromorphone/fentanyl/methadone/oxycodone) had MEDD escalation by 1230-16300% by discharge compared to immediately before BMT-related pain escalation. Buprenorphine-supported cases had significantly smaller MEDD increase by 220-317%.
Conclusions/applications: Our case series suggests superior pain control by adding Buprenorphine prior to opioid dose escalation during BMT for SCD. Buprenorphine may provide the advantageous effect for other patients with complex pain background and experiencing difficult pain management during BMT due to pre-existing hyperalgesia and high opioid-tolerance. The evidence for buprenorphine's analgesic effect is moderate but growing, and more randomized controlled trials comparing the buprenorphine and other standard opioids are needed.
Impact of an Education Module on the Knowledge and Attitudes of EM Physicians Towards Prescribing Buprenorphine/Naloxone for Opioid Use Disorder
Authors: Zosel Amy , Hernandez-Meier Jennifer , Owen Julie 
Published: September 2024

Background: Opioid overdose continues to be a major cause of morbidity and mortality. Buprenorphine is an important treatment for patients with opioid-use disorder (OUD) and initiation in the emergency department (ED) has been shown to improve outcomes for these patients.
Purpose/hypothesis: Our objective was to assess the impact of a three-pronged education package on the knowledge and attitudes of emergency physicians towards using buprenorphine for treatment of OUD.
Procedures/data/observations: We developed a three-pronged educational package including background rationale for OUD treatment with buprenorphine, an evidence-based ED buprenorphine induction pathway and electronic medical record tools. This package was deployed to providers in an urban academic ED. A voluntary confidential pre-post survey was administered. Using a 6-point Likert Scale, participants were asked about their understanding, experience, and confidence with prescribing.
Conclusions/applications: A one-hour, three-pronged educational package changed the attitudes of emergency physicians towards buprenorphine treatment and demonstrated an increase in willingness and confidence to prescribe it for patients with OUD. Our findings suggest that healthcare entities that wish to boost buprenorphine prescribing can impact willingness and confidence to prescribe with a short education package.