bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality-of-life outcomes from NRG Oncology NSABP B-39/RTOG 0413: whole-breast irradiation vs accelerated partial-breast irradiation after breast-conserving surgery
Authors: Ganz Patricia A , Cecchini Reena S , White Julia R , Vicini Frank A , Arthur Douglas W , Rabinovitch Rachel A , Kuske Robert R , Julian Thomas B , Parda David S , Scheier Michael F , Winter Kathryn A , Paik Soonmyung , Kuerer Henry M , Vallow Laura A , Pierce Lori J , Mamounas Eleftherios P , McCormick Beryl , Bear Harry D , Germain Isabelle , Gustafson Gregory S , Grossheim Linda , Petersen Ivy A , Hudes Richard S , Curran Jr Walter J , Wolmark Norman 
Published: September 2024

Abstract

Background
NRG Oncology NSABP B-39/RTOG 0413 compared whole-breast irradiation (WBI) to accelerated partial-breast irradiation (APBI). APBI was not equivalent to WBI in local tumor control. Secondary outcome was quality of life (QOL).

Methods
The QOL sub-study used validated self-report questionnaires, including the Breast Cancer Treatment Outcome Scale (BCTOS) and the 36-Item Short Form Health Survey (SF-36) vitality scale. Assessments occurred before random assignment, at treatment completion (chemotherapy or radiotherapy), 4 weeks later, at 6, 12, 24, and 36 months. Primary aims: cosmesis change equivalency (baseline to 3 years; a priori margin of equivalence 0.4 standard deviations) and fatigue change superiority (baseline to end of treatment [EOT]) for APBI vs WBI, by patient groups treated with or without chemotherapy when appropriate.

Results
From March 21, 2005 to May 25, 2009, 975 patients enrolled in this sub-study; 950 had follow-up data. APBI had 3-year cosmesis equivalent to WBI (95% CI = -0.0001 to -0.16; equivalence margin -0.22 to -0.22) in all patients. The APBI group without chemotherapy had less EOT fatigue (P = .011; mean score APBI 63 vs WBI 59); the APBI group receiving chemotherapy had worse EOT fatigue (P = .011; APBI 43 vs WBI 49). The APBI group reported less pain (BCTOS) at EOT (WBI 2.29 vs APBI 1.97) but worse pain at 3 years (WBI 1.62 vs APBI 1.71). APBI patients reported greater convenience of care than with WBI and reported less symptom severity at EOT and 4 weeks later.

Conclusion
Cosmetic outcomes were similar for the APBI and WBI groups, with small statistically significant differences in other outcomes that varied over time. Differences in fatigue and other symptoms appeared to resolve by ≥6 months. APBI may be preferred by some patients, for whom extended treatment is burdensome.

ClinicalTrials.gov
NCT00103181.
DIRT/µ: automated extraction of root hair traits using combinatorial optimization
Authors: Pietrzyk Peter , Phan-Udom Neen , Chutoe Chartinun , Pingault Lise , Roy Ankita , Libault Marc , Saengwilai Patompong Johns , Bucksch Alexander 
Published: September 2024

Abstract
As with phenotyping of any microscopic appendages, such as cilia or antennae, phenotyping of root hairs has been a challenge due to their complex intersecting arrangements in two-dimensional images and the technical limitations of automated measurements. Digital Imaging of Root Traits at Microscale (DIRT/μ) is a newly developed algorithm that addresses this issue by computationally resolving intersections and extracting individual root hairs from two-dimensional microscopy images. This solution enables automatic and precise trait measurements of individual root hairs. DIRT/μ rigorously defines a set of rules to resolve intersecting root hairs and minimizes a newly designed cost function to combinatorically identify each root hair in the microscopy image. As a result, DIRT/μ accurately measures traits such as root hair length distribution and root hair density, which are impractical for manual assessment. We tested DIRT/μ on three datasets to validate its performance and showcase potential applications. By measuring root hair traits in a fraction of the time manual methods require, DIRT/μ eliminates subjective biases from manual measurements. Automating individual root hair extraction accelerates phenotyping and quantifies trait variability within and among plants, creating new possibilities to characterize root hair function and their underlying genetics.
Rubidium and Cesium Ion-Induced Electron and Ion Signals for Scanning Ion Microscopy Applications
Authors: Li Yang , Xu Sheng , Loeber Thomas H , Vredenbregt Edgar J D 
Published: September 2024

Abstract
Scanning ion microscopy applications of novel focused ion beam (FIB) systems based on ultracold rubidium (Rb) and cesium (Cs) atoms were investigated via ion-induced electron and ion yields. Results measured on the Rb+ and Cs+ FIB systems were compared with results from commercially available gallium (Ga+) FIB systems to verify the merits of applying Rb+ and Cs+ for imaging. The comparison shows that Rb+ and Cs+ have higher secondary electron (SE) yields on a variety of pure element targets than Ga+, which implies a higher signal-to-noise ratio can be achieved for the same dose in SE imaging using Rb+/Cs+ than Ga+. In addition, analysis of the ion-induced ion signals reveals that secondary ions dominate Cs+ induced ion signals while the Rb+/Ga+ induced signals contain more backscattered ions.
Posting Holistic Health and Fitness Reels on Social Media Platforms to Improve Soldier Health in the Brigade
Authors: Culley Katelyn , DaLomba Elaina 
Published: September 2024

ABSTRACT

Introduction
As of 2020 Holistic health and fitness (H2F) teams have been embedded into brigades to engage Soldiers in Preventative Mental, Physical, Nutritional, Spiritual, and Sleep Readiness services. This represents a change in Army culture from a focus on testing to one of wellness because of increasing sleep concerns, mental health concerns, and injury rates. Soldier awareness of H2F services, where to find them, how to use them, and command endorsement of H2F professional’s services has been limited and not well studied. Most soldiers fall into the Generations Y and Z categories, and this population tends to access information primarily from social media sources. Social media platforms therefore represent potentially effective ways to reach these individuals to increase their awareness of H2F services.

Materials and Methods
This quality improvement project used therapist produced brief interactive videos covering the topics of sleep hygiene and consequences of sleep supplement use and sleep deprivation, mental readiness, and journaling as a form of mindfulness. Video reels were posted to one brigade H2F’s social media (Facebook and Instagram) platforms to improve Soldier awareness and engagement in wellness activities in these areas. Data were tracked before and after the initiation of the reel series via Facebook and Instagram MetaBusiness Suite, and via utilization tracking for H2F occupational therapy group and 1:1 visits.

Results
Data tracked before and after the initiation of the video series revealed an 898.2% increase in Facebook access, including reel reach, and increases in 1:1 and group sleep and mental readiness visits to the H2F occupational therapist.

Conclusions
The use of social media to facilitate soldier awareness and use of H2F mental and sleep readiness services is a viable option for H2F units seeking to enhance their reach in these areas. The project created very little demand on the local therapist’s time or to brigade resources and may help increase Soldier accessing of H2F resources online and directly.
The Readiness Imperative: Leveraging Large Animal Resident Research to Enhance Expeditionary Surgical Skills
Authors: Fannon Elise E H , Dangan Andrei , Hauck Katrina , Sherazee Elan , Zakaluzny Scott , Tourtillott Brandon M , Savard Dillon J , Russo Rachel 
Published: September 2024

ABSTRACT

Introduction
The Defense Health Agency aims to ensure that military surgical residents have the expeditionary general surgical skills necessary to deploy to a combat environment and maintains the Clinical Investigation Programs (CIPs) that foster research during graduate medical education. This project evaluates the potential to achieve both aims simultaneously through a large animal Combat Casualty Care Research Program (CCCRP).

Materials and Methods
Large animal experimental protocols within a single CIP’s CCCRP were collected from July 1, 2017, to June 30, 2022. Operations performed were tabulated and categorized by Emergency General Surgery procedure equivalent. In addition, procedures performed by a single resident from July 1, 2020, to June 30, 2022, were separately indexed for a more granular analysis.

Results
The results are presented with total 5-year numbers listed first, followed by single resident 2-year numbers in parentheses. The residents at the CIP carried out 8676 (1,609) tabulated procedures. Major surgical procedures included 573 (154) laparotomies, 364 (129) thoracotomies, 279 (125) splenectomies, 219 (108) craniotomies, 206 (81) hepatorrhaphies, 363 (62) nephrectomies, 383 (48) bowel resections, 215 (48) spine exposures with laminectomies, and 173 (9) sternotomies. Additional procedures included 1028 (127) central venous lines, 878 (127) arterial lines, 90 (67) tube thoracostomies, 199 (37) carotid artery exposures, 394 (29) suprapubic urostomies, and placement of 278 (10) aortic occlusion catheters. At this time, the residents had 17 (10) presentations at national meetings, 8 (7) research awards, and published 20 peer-reviewed manuscripts. Additionally, the residents involved in the CCCRP gained valuable experience in critical care, including management of 110 traumatic brain injuries, 121 Intercranial Pressure catheters, 316 cases of hemorrhagic shock, and 211 massive transfusion protocols, among a variety of other vital critical care skills.

Conclusions
This large animal CCCRP represents a unique training model that not only achieves its primary goal of fostering graduate medical education research but also bolsters Emergency General Surgery readiness for military surgical residents.
Decreased spinal cord motor neuron numbers in mice depleted of central nervous system copper
Authors: Liddell J R , Hilton J B W , Wang Y J , Billings J L , Nikseresht S , Kysenius K , Fuller-Jackson J P , Hare D J , Crouch P J 
Published: September 2024

Abstract
Disrupted copper availability in the central nervous system (CNS) is implicated as a significant feature of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Solute carrier family 31 member 1 (Slc31a1; Ctr1) governs copper uptake in mammalian cells and mutations affecting Slc31a1 are associated with severe neurological abnormalities. Here, we examined the impact of decreased CNS copper caused by ubiquitous heterozygosity for functional Slc31a1 on spinal cord motor neurons in Slc31a1+/− mice. Congruent with the CNS being relatively susceptible to disrupted copper availability, brain and spinal cord tissue from Slc31a1+/− mice contained significantly less copper than wild-type littermates, even though copper levels in other tissues were unaffected. Slc31a1+/− mice had less spinal cord α-motor neurons compared to wild-type littermates, but they did not develop any overt physical signs of motor impairment. By contrast, ALS model SOD1G37R mice had fewer α-motor neurons than control mice and exhibited clear signs of motor function impairment. With the expression of Slc31a1 notwithstanding, spinal cord expression of genes related to copper handling revealed only minor differences between Slc31a1+/− and wild-type mice. This contrasted with SOD1G37R mice where changes in the expression of copper handling genes were pronounced. Similarly, the expression of genes related to toxic glial activation was unchanged in spinal cords from Slc31a1+/− mice but highly upregulated in SOD1G37R mice. Together, results from the Slc31a1+/− mice and SOD1G37R mice indicate that although depleted CNS copper has a significant impact on spinal cord motor neuron numbers, the manifestation of overt ALS-like motor impairment requires additional factors.
Prediction of H3K27M alteration in midline gliomas of the brain using radiomics: A multi-institute study
Authors: Indoria Abhilasha , Arora Ankit , Garg Ajay , Chauhan Richa S , Chaturvedi Aparajita , Kumar Manoj , Konar Subhas , Sadashiva Nishanth , Rao Shilpa , Saini Jitender 
Published: September 2024

Abstract

Background
Noninvasive prediction of H3K27M-altered Diffuse midline gliomas is important because of the involvement of deep locations and proximity to eloquent structures. We aim to predict H3K27M alteration in midline gliomas using radiomics features of T2W images.

Methods
Radiomics features extracted from 124 subjects (69 H3K27M-altered/55 H3K27M-wild type). T2W images were resampled to 1 × 1 × 1mm3 voxel size, preprocessed, and normalized for artifact correction, intensity variations. The feature set was normalized and subjected to reduction by variance thresholding, correlation coefficient thresholding, and sequential feature selector. Adaptive synthesis oversampling technique was used to oversample the training data. Random forest classifier (RFC), Decision tree classifier (DTC), and K-nearest neighbors classifier (KNN) were trained over the training dataset and the performance was assessed over the internal test dataset and external test data set (52 subjects: 33 H3K27M-altered/19-H3K27M-wild type).

Results
DTC achieved a validation score of 77.33% (5-fold cross-validation) and an accuracy of 80.64%, 75% on internal and external test datasets. RFC achieved a validation score of 80.7% (5-fold cross-validation) an accuracy of 80.6%, and 73% on internal and external test datasets. DTC achieved a validation score of 78.67% (5-fold cross-validation) an accuracy of 80.64%, and 61.53% on internal and external test datasets. The accuracy score of DTC, RFC, and KNN on the internal test dataset was approximately 80% while on the external test dataset, DTC achieved 75% accuracy, RFC achieved 73% accuracy and KNN achieved 65.1% accuracy.

Conclusions
H3K27M alteration is a potential immunotherapeutic marker and is associated with poor prognosis and radiomics features extracted from conventional T2W-images can help in identifying H3K27M-altered cases non-invasively with high precision.
Peer Navigation for Smoking Cessation in People With HIV Who Smoke: A Pilot Randomized Controlled Trial
Authors: Cioe Patricia A , Pinkston Megan , Stang Garrett S , Tashima Karen T , Kahler Christopher W 
Published: September 2024

Abstract

Introduction
People with HIV (PWH) cite smoking within their social networks as a barrier to quitting. We examined the feasibility, acceptability, and preliminary efficacy of a tailored intervention, Peer Navigation Social Support for Smoking Cessation (PNSS-S), designed specifically for PWH who smoke.

Aims and Methods
We randomized 64 PWH who smoked (mean age 54.5 years; 41% female) to PNSS-S or standard care (SC). After meeting with a clinic nurse to discuss quitting strategies and pharmacotherapy, the PNSS-S group received 12 weekly phone calls from a trained HIV peer navigator (PN), who provided smoking cessation counseling and social support for quitting. Outcomes were assessed at 12 and 24 weeks.

Results
Sixty-two percent of participants indicated interest in quitting at baseline. PN utilization was high with a mean number of weekly calls completed of 8.9 (SD 3.1), demonstrating excellent feasibility. Higher treatment satisfaction scores (29.1 [SD 3.0]) were reported in PNSS-S, compared to control (25.8 [SD 4.1], t = −3.39, d = 0.89, p = .001). Notably, positive social support for quitting increased significantly from baseline to week 12 in PNSS-S (17.4 [SD 11.4] to 25.1 [SD 12.2], p = .01), whereas SC showed no significant change (t = 1.11, df 29, p = .24). At week 24, 5 (16.6%) participants in PNSS-S and 3 (8.8%) in SC endorsed 7-day point-prevalence smoking abstinence: OR = 2.05 95% CI = [0.45 to 10.88].

Conclusions
Peer-based smoking cessation counseling increased the odds of abstinence and significantly increased social support for quitting. Further study is warranted.

Implications
Cross-training HIV PNs to address smoking cessation may be a cost-effective approach, as it utilizes existing HIV clinic-based resources. By strengthening social support and providing a peer-based approach, this intervention may help reduce the burden of tobacco-related health issues in this population, ultimately contributing to better overall health and longevity for PWH. Further research is needed to refine and expand upon these findings.

Clinical Trial Registration
Clinical trials.gov registration number: NCT04327921.
Evaluating Antibiotic Misuse and Cost Analysis Among Hospitalized Dengue Virus–Infected Adults: Insights From a Retrospective Cohort Study
Authors: Ngamprasertchai Thundon , Siribhadra Ashley , Kositamongkol Chayanis , Piroonamornpun Pittaya , Pakdeewut Piyanan , Luvira Viravarn , Lawpoolsri Saranath , Rattanaumpawan Pinyo 
Published: September 2024

Abstract

Background
Dengue is a prevalent cause of acute febrile illness, predominantly in Asia, where it necessitates supportive care without the need for antibiotics. This study aimed to evaluate antibiotic usage and analyze hospitalization costs among adults infected with the dengue virus.

Methods
This retrospective cohort study was conducted at the Hospital for Tropical Diseases, Thailand, in 2022. Two independent reviewers assessed all adult cases with confirmed dengue from 2016 to 2021. Determinants of inappropriateness were analyzed using Poisson regression.

Results
The study included 249 participants with over half presenting with severe dengue or dengue with warning signs upon admission. The cumulative incidence of antibiotic use was 9.3% (95% CI, 8.23–10.47), predominantly involving empirical treatment strategies. Ceftriaxone and doxycycline were the most frequently prescribed antibiotics. Notably, patients who received empirical antibiotics showed no definite or presumed bacterial infections. Among those who received definite strategies, inappropriate durations, including both short treatments and the overuse of broad-spectrum antibiotics, were observed. A private ward admission was identified as a significant predictor of inappropriate use, with an incidence rate ratio of 4.15 (95% CI, 1.16–14.82) compared with intensive care unit admission. Direct medical costs did not differ significantly between appropriate and inappropriate uses.

Conclusions
The incidence of antibiotic use among dengue cases was moderate; however, inappropriate use by indication was observed. Antimicrobial stewardship strategies should be encouraged, particularly in patients with dengue with warning signs admitted to a general or private ward. Direct medical costs between appropriate and inappropriate use were comparable.
The Genetics of Plant–Plant Interactions and Their Cascading Effects on Agroecosystems—from Model Plants to Applications
Authors: Sato Yasuhiro , Wuest Samuel E 
Published: September 2024

Abstract
Plants are typically surrounded by neighboring individuals in agricultural fields or natural environments. In such circumstances, plant–plant interactions (PPI) are ubiquitous and represent not only important evolutionary forces but also have consequences on (agro-)ecosystem functioning, such as increased productivity and resistance. However, many mechanisms underlying these PPIs remain poorly understood. Recently, new genomic technologies and tools, such as genome-wide association studies, have facilitated genetic approaches to study PPIs, particularly among conspecific individuals. Here, we highlight emerging issues and advances in the field by focusing on three different aspects. First, we overview the current status of genetic mapping studies on PPIs and pinpoint that these studies open a new opportunity that is relevant to agriculture and breeding. Second, we introduce two proof-of-concept studies in Arabidopsis thaliana, in which genetic differences among plants improved the functioning of genotype mixtures. Both studies were able to predict effective mixtures with different experimental designs applied to different outcomes (productivity increase versus herbivory mitigation). Third, we discuss implications from these case studies about how PPIs have cascading effects that propagate to higher levels of biological organization, such as populations or communities. At the population level, plant yield or resistance can be optimized through breeding that achieves reduced competition or push–pull protection systems, respectively. At the community level, these population-level changes may have further beneficial effects on plant-associated organisms. Overall, we suggest that the increasing availability of genomic resources will improve our understanding of PPIs and thereby contribute to the management of crops or seminatural ecosystems.
Soft cells and the geometry of seashells
Authors: Domokos Gábor , Goriely Alain , Horváth Ákos G , Regős Krisztina 
Published: September 2024

Abstract
A central problem of geometry is the tiling of space with simple structures. The classical solutions, such as triangles, squares, and hexagons in the plane and cubes and other polyhedra in three-dimensional space are built with sharp corners and flat faces. However, many tilings in Nature are characterized by shapes with curved edges, nonflat faces, and few, if any, sharp corners. An important question is then to relate prototypical sharp tilings to softer natural shapes. Here, we solve this problem by introducing a new class of shapes, the soft cells, minimizing the number of sharp corners and filling space as soft tilings. We prove that an infinite class of polyhedral tilings can be smoothly deformed into soft tilings and we construct the soft versions of all Dirichlet–Voronoi cells associated with point lattices in two and three dimensions. Remarkably, these ideal soft shapes, born out of geometry, are found abundantly in nature, from cells to shells.
Measuring receptivity to misinformation at scale on a social media platform
Authors: Tokita Christopher K , Aslett Kevin , Godel William P , Sanderson Zeve , Tucker Joshua A , Nagler Jonathan , Persily Nathaniel , Bonneau Richard 
Published: September 2024

Abstract
Measuring the impact of online misinformation is challenging. Traditional measures, such as user views or shares on social media, are incomplete because not everyone who is exposed to misinformation is equally likely to believe it. To address this issue, we developed a method that combines survey data with observational Twitter data to probabilistically estimate the number of users both exposed to and likely to believe a specific news story. As a proof of concept, we applied this method to 139 viral news articles and find that although false news reaches an audience with diverse political views, users who are both exposed and receptive to believing false news tend to have more extreme ideologies. These receptive users are also more likely to encounter misinformation earlier than those who are unlikely to believe it. This mismatch between overall user exposure and receptive user exposure underscores the limitation of relying solely on exposure or interaction data to measure the impact of misinformation, as well as the challenge of implementing effective interventions. To demonstrate how our approach can address this challenge, we then conducted data-driven simulations of common interventions used by social media platforms. We find that these interventions are only modestly effective at reducing exposure among users likely to believe misinformation, and their effectiveness quickly diminishes unless implemented soon after misinformation’s initial spread. Our paper provides a more precise estimate of misinformation’s impact by focusing on the exposure of users likely to believe it, offering insights for effective mitigation strategies on social media.