bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Skin of Color Curricular Content for Physician Assistant Education
Authors: Chintalapati Namrata V. , Poondru Sneha , Kundu Roopal V. , Liveris Marissa O. , Riley Julia M. 
Published: September 2024

Introduction
Physician assistants (PAs) are often members of dermatologic care teams. Adequate knowledge of dermatologic conditions in skin of color (SOC) is crucial to proper diagnosis, treatment, and patient satisfaction. The objective of this study was to increase PA students' objective knowledge of and comfort level with evaluating dermatologic conditions in SOC.

Methods
Eligible participants included 36 PA students at a major metropolitan medical center during the 2022 to 2023 academic year. A preintervention survey, immediate postintervention survey, and 7-month follow-up postintervention survey were administered before and after a SOC lecture. The surveys concluded with a 10-question, image-based, multiple-choice examination.

Results
There was a significant increase in accurate diagnoses of acne scarring, eczema, psoriasis, rosacea, and seborrheic dermatitis in SOC (59.4% preintervention to 76.9% postintervention, P = .029). Student confidence, as rated on a scale of 1 (minimally confident) to 5 (extremely confident), in diagnosing these conditions increased from 2.97 to 3.52 (P = .036).

Discussion
Implementation of a SOC-specific dermatology lecture significantly increased the accuracy and confidence with which PA students diagnosed dermatologic conditions.
Emerging public health strategies in malaria control: innovations and implications
Authors: Obeagu Emmanuel Ifeanyi , Obeagu Getrude Uzoma 
Published: September 2024

Malaria remains a significant global health challenge, particularly in regions with limited resources and tropical climates. Despite extensive efforts, the disease continues to cause significant morbidity and mortality, with ~229 million cases and 409 000 deaths reported in 2020. However, recent years have seen promising advancements in public health strategies aimed at malaria control and elimination. Technological advancements have played a crucial role in improving malaria control efforts. Genomic surveillance techniques enable the monitoring of malaria parasite populations, aiding in the detection of drug resistance and informing targeted interventions. Additionally, innovative diagnostic technologies, such as rapid diagnostic tests (RDTs) and molecular assays, have enhanced the speed and accuracy of malaria diagnosis, facilitated prompt treatment and reduced transmission. These tools are instrumental in achieving the WHO goals of reducing malaria cases and deaths by at least 90% by 2030. Novel vector control methods offer innovative approaches to reduce malaria transmission. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) remain foundational strategies, with advancements including the development of next-generation insecticides and long-lasting insecticidal nets (LLINs). Furthermore, genetic modification of mosquitoes, such as gene drive technology, holds promise for reducing mosquito populations and interrupting malaria transmission. These vector control innovations complement other strategies, contributing to comprehensive malaria control efforts aimed at achieving sustainable disease reduction and eventual elimination.
Working with partial hand prostheses: An investigation into experiences of clinicians
Authors: Carlyle Kirsty , Buis Arjan , Donovan-Hall Maggie , Day Sarah 
Published: September 2024

Background:
Individuals living with partial hand absence often face challenges in performing everyday tasks and fully participating in society. Prosthetic devices offer a range of benefits, including improved functionality or cosmesis. However, partial hand devices can be rejected by users. In addition, there is a lack of evidence that establishes methods or factors influencing the clinical prescription of prosthetics specifically designed for this population.

Objectives:
The objectives of the investigation were to gain understanding of who is prescribing partial hand prosthetics and the factors which influence device selection.

Study Design:
A 36-item anonymous online survey was designed on Qualtrics and distributed to clinicians. The survey contained multiple-choice, Likert-type, closed, and open-ended questions.

Methods:
Quantitative and qualitative analyses were performed on Qualtrics and Microsoft Excel.

Results:
Thirty-seven clinicians from various occupations participated. The majority agreed that outcome measures are useful for assessing partial hand prosthetics but suggested room for improvement. Although clinicians use various outcome measurement tools, there is a lack of tools specifically tailored to this population. Factors such as existing function, occupation, and hobbies were identified as important when selecting prosthetic devices for users. Funding influenced the range of partial hand devices available for prescription.

Conclusions:
The prescription process involves multiple stakeholders. Various factors, including funding and user satisfaction, must be considered in the decision-making process. There is a lack of specific outcome measures recommended for evaluating prosthetics in this population. However, providing loaner units before final prescription yields positive outcomes.
In vitroandin vivoevaluation ofUlva lactucafor wound healing
Authors: Wang Chien-Hsing , Huang Zih-Ting , Tai Kuo-Feng 
Published: September 2024

AbstractUlva lactuca(U.lactuca) is an important seaweed species. Some ingredients in these seaweeds are thought to accelerate wound healing. However, limited data on the use of seaweed for wound healing exists. This study examined whether ethanol or aqueous extracts ofU.lactucapromote antioxidant and anti-inflammatory propertiesin vitroand wound healingin vitroandin vivo. Cell proliferation, antioxidation, and migration were observed in NIH3T3 cells treated withU.lactucaextractin vitro. BothU.lactucaextracts were examined for their ability to inhibit inflammatory cytokine synthesis in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.In vivoexperiments involved four groups of albino mice (BALB/c; 10 mice per group). One 1.0 cm2wound was created via excision of full-thickness skin on the back of all mice. Mice in Group I mice were treated topically with the ethanol extract ofU.lactuca(25 mg/mL) for 10 d. group II mice were treated topically with an aqueous extract ofU.lactuca(12.5 mg/mL) for 10 d. Group III received topical application of phosphate-buffered saline solution. Group IV wounds were maintained without treatment. Both extracts significantly increased fibroblast proliferation. The antioxidant activity of theU.lactucaextract was determined using a total antioxidant capacity assay. Both extracts inhibited the release of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) from LPS-mediated inflammation in RAW 264.7 cells. These extracts also upregulated the expression of Th2 cytokines such as transforming growth factor beta 1 (TGF-β1) and interleukin 10 (IL-10) in RAW 264.7 cells under pro-inflammatory conditions. Both extracts enhanced the migratory ability of NIH3T3 cells.U.lactucaethanol extract enhances wound healing propertiesin vivo. These results suggest that bioactive compounds derived fromU.lactucaextract are beneficial for wound healing and anti-inflammatory therapies.
Learning on a Limb: An outreach module to engage high school students in orthopaedics
Authors: Panebianco Christopher J. , Azar Tala F. , Duffy Michael P. , Nijsure Madhura P. , Sharp Emily , Tamburro Margaret K. , Hast Michael , Shore Eileen M. , Mauck Robert L. , Soslowsky Louis J. , Shuda Jamie R. , Gullbrand Sarah E. 
Published: September 2024

AbstractOrthopaedic researchers need new strategies for engaging diverse students. Our field has demonstrated noticeable gaps in racial, ethnic, and gender diversity, which inhibit our ability to innovate and combat the severe socioeconomic burden of musculoskeletal disorders. Towards this goal, we designed, implemented, and evaluated Learning on a Limb, an orthopaedic research outreach module to teach diverse high school students about orthopaedic research. During the 4-hr module, students completed hands-on activities to learn how biomechanical testing, microcomputed tomography, cell culture, and histology are used in orthopaedic research. Over three years, we recruited 32 high school students from the Greater Philadelphia Area to participate in Learning on a Limb. Most participants identified as racial/ethnic or gender minorities in orthopaedic research. Using pre/post-tests, we found that students experienced significant learning gains of 51 percentage points from completing Learning on a Limb. In addition to teaching students about orthopaedic research, post-survey data demonstrated that participating in Learning on a Limb strongly influenced students’ interest in orthopaedic research. Several students acted on this interest by completing summer research experiences in the McKay Orthopaedic Research Laboratory at the University of Pennsylvania. Learning on a Limb instructors also benefited by having the opportunity to “pay it forward” to the next generation of students and build community within their department. Empowering institutions to host modules like Learning on a Limb would synergistically inspire diverse high school students and strengthen community within orthopaedic departments to ultimately enhance orthopaedic research innovations.
CRISPR screen for rAAV production implicates genes associated with infection
Authors: O’Driscoll Emily E , Arora Sakshi , Lang Jonathan F , Davidson Beverly L , Shalem Ophir 
Published: September 2024

ABSTRACTRecombinant adeno-associated virus (rAAV) vectors are an effective and well-established tool in the growing gene therapy field, with five FDA-approved AAV-mediated gene therapies already on the market and numerous more in clinical trials. However, manufacturing rAAV vectors is an expensive, timely, and labor-intensive process that limits the commercial use of AAV-mediated gene therapies. To address this limitation, we screened producer cells for genes that could be targeted to increase rAAV yield. Specifically, we performed a CRISPR-based genome-wide knockout screen in HEK 293 cells using an antibody specific to intact AAV2 capsids coupled with flow cytometry to identify genes that modulate rAAV production. We discovered that the knockout of a group of heparan sulfate biosynthesis genes previously implicated in rAAV infectivity decreased rAAV production. Additionally, we identified several vesicular trafficking proteins for which knockout in HEK 293 cells increased rAAV yields. Our findings provide evidence that host proteins associated with viral infection may have also been co-opted for viral assembly and that the genetic makeup of viral producer cells can be manipulated to increase particle yield.
Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex are Preserved Across Mice and Rats Despite Dramatic Changes in Key Marker Genes
Authors: Brooks Isla A.W. , Jedrasiak-Cape Izabela , Rybicki-Kler Chloe , Ekins Tyler G. , Ahmed Omar J. 
Published: September 2024

ABSTRACTThe granular retrosplenial cortex (RSG) supports key functions ranging from memory consolidation to spatial navigation. The mouse RSG contains several cell types that are remarkably distinct from those found in other cortical regions. This includes the physiologically and transcriptomically unique low rheobase neuron that is the dominant cell-type in RSG layers 2/3 (L2/3 LR), as well as the similarly exclusive pyramidal cells that comprise much of RSG layer 5a (L5a RSG). While the functions of the RSG are extensively studied in both mice and rats, it remains unknown if the transcriptomically unique cell types of the mouse RSG are evolutionarily conserved in rats. Here, we show that mouse and rat RSG not only contain the same cell types, but key subtypes including the L2/3 LR and L5a RSG neurons are amplified in their representations in rats compared to mice. This preservation of cell types in male and female rats happens despite dramatic changes in key cell-type-specific marker genes, with theScnn1aexpression that selectively tags mouse L5a RSG neurons completely absent in rats. Important for Cre-driver line development, we identify alternative, cross-species genes that can be used to selectively target the cell types of the RSG in both mice and rats. Our results show that the unique cell types of the RSG are evolutionarily conserved across millions of years of evolution between mice and rats, but also emphasize stark species-specific differences in marker genes that need to be considered when making cell-type-specific transgenic lines of mice versus rats.
Validation of a dispositional critical thinking scale using an original analytical methodology for addressing data from Google Trends
Authors: Pérez Rave Jorge Iván , Fernández Guerrero Rafael , Salas Vallina Andres 
Published: September 2024

PurposeA methodological approach is required that complements studies based on surveys, providing a perspective with greater truthfulness and coverage. The study aims to develop a methodology to validate psychological/managerial constructs using data from Google Trends, taking as a case study a critical thinking (CT) scale in organizational domains previously supported by survey data.Design/methodology/approachThe developed methodology consists of eight stages, in which the following is integrated: (1) Internet search interest data (19 Spanish-speaking countries); (2) deductive research processes (e.g. theoretical model, linguistic manifestations, fieldwork, data matrix, analysis statistical, reporting); (3) psychometric properties (e.g. construct validity, criterion validity, reliability) and (4) objective data to examine criterion validity (e.g. unemployment rate).FindingsThe application of the methodology produces evidence that supports the reliability (Cronbach’s alpha, Guttman’s λ4), construct validity (intra-correlations and correlations with reference variables: “entrepreneurship,” “critical thinking,” “soccer,” “beer,” “pornography”) and criterion validity (prediction of unemployment rate) of the CT scale.Research limitations/implicationsThe methodology makes it possible to support or invalidate the quality of construct measurement scales by planning, capturing and processing data available on the internet.Practical implicationsThis manuscript is useful for research in business management (and related areas), which is intensive in the use of psychological/managerial constructs.Originality/valueThe methodology uses a new type of evidence; it is noninvasive, usually more truthful than responses to surveys, and has greater coverage of people participating indirectly in the study.
Work value profiles across cultures: an application of the multiple-group latent profile procedure in Switzerland, Spain, the United States and China
Authors: Valero Domingo , Froidevaux Ariane , Zhang Chunyu , González-López María José 
Published: September 2024

PurposeThis study explores the differences and similarities of work value profiles in samples of business students from four countries with markedly different cultures and labor markets.Design/methodology/approachWe used multiple-group latent profile analysis (LPA) to explore the differences and similarities in work value profiles across cultures (n = 317 from Switzerland, n = 313 from Spain, n = 326 from the United States and n = 327 from China).FindingsThe latent profiles mostly show similarities across countries: the largest profiles are a want it all and a humble profile with overall high and intermediate levels in all work values. An overall low work value levels profile and one stressing high security and pay emerged in all countries except Switzerland. In the Swiss sample, two unique profiles emerged: the no status and freelancers profiles.Practical implicationsThis study has implications for employee attraction, relations and career counseling with culturally diverse populations.Originality/valueStudies on work values across cultures most often make direct comparisons between samples, which can lead to excessive emphasis on sometimes small differences. By first studying within-culture differences before comparing the results across cultures, we find that there may be more similarities than differences in work values across cultures and that cross-cultural differences may have often been overstated.
Multimethod digitalisation of a large-format school map from the first half of the 20th century
Authors: Carrasco-Huertas Ana , Reyes Pérez Ana , Campillo García Domingo 
Published: September 2024

Purpose
This study aims to delve into the effectiveness of applying traditional and more advanced digital means to document elements of cultural heritage, in this case large-format cartography. Application of multimethod digitalisation to a school map of the American continent dating to the early part of the 20th century has served to address specific issues, notably its multilayers consisting of paper, inks and a protective varnish on a textile medium. Its large format is likewise an obstacle to its digital capture.

Design/methodology/approach
The method applied here resorted to three registration systems: single-shot photography, panoramic photography and photogrammetry. The first two widely serve to capture works of large-format, whereas the third is commonly used to record volumetric assets. A variety of parameters were applied, notably different focal lengths, capture methods and processing software. The images obtained in each case were subjected to qualitative and quantitative comparisons so as to analyse their differences in terms of resolution and accuracy when compared to the map's real measurements, key criteria when duplicating cartographic documents.

Findings
Although the final products gleaned from the digital photographs, panoramic photographs and photogrammetry fulfil the basic functions required to record documents housed in archives, libraries, museums and other cultural institutions, this study highlights new advances and complementary functions stemming from certain of these techniques.

Originality/value
Digitalisation is a tool that serves to register, preserve, disseminate and analyse cultural heritage. However, some of the available techniques have rarely been applied specifically to graphic and documentary artefacts. It is for this reason that this study intends to demonstrate their utility in the detailed study of this heritage typology. Moreover, optimising the school map into a digital form favours its dissemination and remote consultation while simultaneously minimising direct manipulation, hence improving its long-term preservation.
Post-acquisition transformation challenges: how did the change in ownership affect Soni Manipal Hospital, Jaipur, in the early years?
Authors: Singh Upasana , Dasgupta Shilpee , Yaduvanshi Deepak 
Published: September 2024

Subject area of the teaching case
MBA.

Student level and proposed courses the teaching case can be used on
Master’s level in Change Management, Organizational Leadership and Human Resource Management.

A brief overview of the teaching case
Mr Sharma, the dynamic and entrepreneurial Chief Executive Officer (CEO) of the newly formed Soni Manipal Hospital (SMH), Jaipur, and Unit Head, Manipal Hospitals [Manipal Health Enterprises Pvt Ltd. (MHEPL)], in a meeting with SMH’s Head of Human Resources and the Head of the Nursing Management, Mr Yaduvanshi realised the exponential growth of employee resistance, their lack of skills and technological advancements for documentation hindering the hospital's transformation goal. The case study highlighted the challenges the protagonist faced when taking charge as the CEO after nine months of acquisition and the factors contributing to them.

Expected learning outcomes
Students reading this case are expected to understand leadership theories, strategic and quality management approaches, and theories of social behaviour, such as Herzberg’s two-factor theory and social exchange theory (SET) and the application of these concepts in acquired organisations to develop healthy leadership–employee relations and change management theories.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 6: Human resource management.
The merger of Slice and North East Small Finance Bank: a marriage made in heaven?
Authors: Agarwal Manish , Kandi V.S. Prasad 
Published: September 2024

Learning outcomes
After completion of the case study, the students will be able to explore the challenges involved in growing a business during its early stages inorganically, discuss the challenges faced by start-ups in their quest for growth in an emerging market, investigate the reasons behind the mergers and acquisitions, comprehend the issues in the merger of a start-up and a conventional bank, identify the various possible synergies out of the merger and examine the growth strategies that a troubled start-up such as Slice can follow to survive and expand its business operations.

Case overview/synopsis
The case study discusses the challenges that Slice, a modern fintech organization, and North East Small Finance Bank (NESFB) face due to the changing business and regulatory environment. After working tirelessly to earn the trust of India’s banking regulator, Slice got the approval for its merger with NESFB. While Slice and NESFB got a new lease of life after the approval of their merger, Rajan Bajaj, founder of Slice, needed to make the merger a success by leveraging on the strength of the combined entity and meeting all the lending and other regulatory requirements applicable to small finance banks.

Complexity academic level
This case study is suitable for MBA/MS/BBA/BS students.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
The commercialisation of NTFPs and conservation of forest: a systematic review for forestry policy
Authors: Atinga Enoch , Bannor Richard Kwasi 
Published: September 2024

PurposeThis current review examines the scientific literature report on non-timber forest products (NTFPs) commercialisation and forest conservation in different jurisdictions.Design/methodology/approachA systematic review using Scopus-indexed articles on NTFP commercialisation and forest conservation was done using the PRISMA framework.FindingsThe review categorised the factors influencing the commercialisation of NTFPs and forest conservation into five broad factors and sub-factors: socioeconomic, market-based, ecosystem, cultural and institutional factors. The scholarly publications on NTFP commercialisation and forest conservation have been undulating, with two years recording no publication on the subject matter under review. Besides, China and India in Asia are leading in the number of publications on NTFPs’ commercialisation. The review revealed ambivalence and symbiotic relationship among the factors influencing the commercialisation of NTFPs and forest conservation. Specifically, tenure arrangement, strict regulations to forest entry, market information asymmetry, bureaucracy in certification acquisition, seasonality and distance were identified as barriers to NTFPs’ commercialisation. While market demands for NTFPs increased, NTFPs’ prices and unsustainable harvesting activities were threats to forest conservation. Policymakers should focus on safeguarding customary property rights and indigenous knowledge in forest conservation, designing workable capacity-building schemes for NTFP entrepreneurs and reducing the cost and processes in certification acquisition.Originality/valueThere are reviews on NTFPs’ commercialisation and livelihoods, but a synergy between NTFPs’ commercialisation and forest conservation for forest policy direction is yet to be done in the literature. Also, while earlier studies systematically reviewed literature on NTFPs’ commercialisation, they did not relate the studies to forest conservation.