bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicians' Review of Significant Interventions by Clinical Pharmacists in Inpatient Care
Authors: Hatoum Hind T. , Hutchinson Richard A. , Elliott Lawana R. , Kendzierski Donald L. 
Published: May 2016

Clinical pharmacists in this study hospital reported 1027 interventions in patient drug therapy over two time periods of three and two weeks each. When peer-reviewed for clinical significance, 36 of these interventions were deemed significant in terms of saving patients' lives or preserving major organ functions; 983 were judged to improve drug therapy to an acceptable level based on standards of the professional literature (8 recommendations were informational i.e., not clinically significant). These 36 interventions were subjected to an independent, blind review by three practicing physicians who were given the same ranking system for clinical relevance as the one used by the peer reviewers. The physicians independently concurred with the peer reviewers on the two interventions initially ranked as 6 (lifesaving in nature). Of the interventions ranked 5 (preserving major organ functions) by the peer-review group, 53 percent were given a rank of 5 by the physicians. However, the remaining 47 percent were given a rank of 4 (upgrading patient drug therapy to the most appropriate level based on professionally accepted standards). In this era of program evaluation and justification, the process of encouraging other health professionals to review pharmacists' contribution to patient care should not be overlooked.
Magnetic resonance venography to assess thrombus resolution with edoxaban monotherapy versus parenteral anticoagulation/warfarin for symptomatic deep vein thrombosis: A multicenter feasibility study
Authors: Piazza Gregory , Mani Venkatesh , Goldhaber Samuel Z , Grosso Michael A , Mercuri Michele , Lanz Hans J , Schussler Steven , Hsu Ching , Chinigo Amy , Ritchie Bruce , Nadar Venkatesh , Cannon Kevin , Pullman John , Concha Mauricio , Schul Marlin , Fayad Zahi A ,   for the edoxaban Thrombus Reduction Imaging Study (eTRIS) Investigators
Published: May 2016

The feasibility of magnetic resonance venography (MRV) for measuring change in thrombus volume with a novel anticoagulation regimen versus standard anticoagulation in patients with symptomatic deep vein thrombosis (DVT) has not been assessed. Our aim was to study the feasibility of MRV to measure change in thrombus volume in patients with acute symptomatic objectively confirmed proximal DVT in an open-label multicenter trial (edoxaban Thrombus Reduction Imaging Study, eTRIS). We randomized patients in a 2:1 allocation ratio to edoxaban 90 mg/day for 10 days followed by 60 mg/day versus parenteral anticoagulation bridging to warfarin for 3 months. The primary efficacy outcome was a surrogate end point of the relative change in MRV-quantified thrombus volume from baseline to Day 14–21. A total of 85 eligible patients from 26 study sites were randomized to edoxaban monotherapy ( n=56) versus parenteral anticoagulation as a ‘bridge’ to warfarin ( n=29). The mean relative change in MRV-quantified thrombus volume from baseline to Day 14–21 was similar in patients treated with edoxaban and parenteral anticoagulation as a ‘bridge’ to warfarin (−50.1% vs −58.9%; 95% confidence interval of treatment difference, −12.7%, 30.2%). However, thrombus extension was observed in eight patients in the edoxaban monotherapy group and in none in the warfarin group. Rates of recurrent venous thromboembolism (3.6% vs 3.6%, p=0.45) and clinically relevant non-major bleeding (5.4% vs 7.1%, p=0.34) were also similar. No major bleeds occurred in either on-treatment group during the study period. In conclusion, MRV can assess change in thrombus volume in patients with acute DVT randomized to two different anticoagulant regimens. ClinicalTrials.gov Identifier: NCT01662908 Investigational New Drug (IND) Application: Edoxaban IND # 63266
Aspirin use and the risk of bleeding complications after therapeutic bronchoscopy
Authors: Harris Kassem , Kebbe Jad , Modi Kush , Alraiyes Abdul Hamid , Kumar Abhishek , Attwood Kristopher , Dhillon Samjot S. 
Published: May 2016

Background: Aspirin use has been shown to be safe for patients undergoing certain diagnostic bronchoscopy procedures such as transbronchial biopsies and endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration. However, there are no studies documenting the safety of aspirin in patients undergoing therapeutic bronchoscopy. The aim of this study is to evaluate whether aspirin increases the risk of bleeding following therapeutic bronchoscopy. Methods: This was a retrospective study to determine if there was a higher risk of bleeding in patients on aspirin undergoing therapeutic bronchoscopy compared with those not on aspirin. Patient characteristics were reported by cohort using the mean, median, and standard deviation for continuous variables, and using frequencies and relative frequencies for categorical variables. Results: Of the 108 patients who had multimodality therapeutic bronchoscopy, 17 (15.7%) were taking aspirin and 91 (84.3%) were not on aspirin. Patients in the aspirin group were older than those in the no aspirin group (median age: 66 versus 60 years, p = 0.007). The treatment modalities were similar in both groups except that more patients in the no aspirin group were treated with argon plasma coagulation (APC) compared to the aspirin group (60.4% versus 29.4%, p = 0.031). The estimated blood loss (EBL) between the aspirin and no aspirin groups was not significantly different (mean: 6.0 versus 6.7 ml; median: 5.0 versus 5.0, p = 0.36). Overall, there was no difference in complications between both groups. Conclusion: Aspirin use was not associated with increased risk of bleeding or procedure-related complications after therapeutic bronchoscopy.
The combined use of steam-treated bentonites and natural zeolites in the oenological refining process
Authors: Mercurio M. , Bish D. L. , Cappelletti P. , de Gennaro B. , de Gennaro M. , Grifa C. , Izzo F. , Mercurio V. , Morra V. , Langella A. 
Published: May 2016

AbstractIndustrial minerals, particularly bentonites, have long been used in treatments to improve the stability and shelf life of white wines. We evaluated a new combination of rocks and minerals, including steam-treated bentonites and natural zeolites (chabazite and phillipsite), to greatly reduce the risk of protein and tartaric instability of wines. Detailed mineralogical, chemical and electrokinetic studies of these materials were conducted using powder X-ray diffraction (PXRD), X-ray fluorescence (XRF), microporosimetry, BET surface-area analysis and zeta-potential measurements. Several model wine solutions containing Bovine Serum Albumin (BSA) were prepared to evaluate the oenological performance of the rock/mineral combinations. UV-VIS spectrophotometry and ion chromatography were used to evaluate the degree of wine stabilization from the protein and tartaric point of view.The experimental results showed that steam treatment modifies both the microporosity and external surface area of the bentonite. These changes in surface area, along with creation of hydrophobic surfaces, significantly modified the behaviour of the steam-treated bentonites, requiring an increase in the amount of material necessary to bring the protein content to required levels. An important benefit derived from the use of steam-treated bentonites is that the pre-mixing with water before addition to wine is not necessary, as the material is readily dispersed. Finally, the addition of natural zeolites effectively decreased the potassium content, thereby improving the tartaric stability of white wines. In addition, this procedure results in minimal waste, as the bentonite-zeolite mixture can be reused as soil amendments in agriculture.
The Great Barrier Reef Expedition 1928–29: The crystal structure and occurrence of weddellite, ideally CaC2O4·2.5H2O, from the Low Isles, Queensland
Authors: Mills Stuart J. , Christy Andrew G. 
Published: May 2016

Abstract“Envelope crystals” collected during The Great Barrier Reef Expedition in May 1929 have been studied using low-temperature synchrotron single-crystal X-ray diffraction. The crystals are shown to be weddellite, with the largest content of zeolitic water reported to date. A new H2O site has been located within the crystal structure. Study of the crystals show that the end-member formula for weddellite should be reported as CaC2O4·(2.5 – x)H2O, where 0≤x≤ 0.25, instead of CaC2O4·(2H2O or CaC2O4·(2 + x )H2O. This is also the first report of weddellite occurring in a coral reef.
FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease
Authors: Schneider Christof , Kon Ning , Amadori Letizia , Shen Qiong , Schwartz Friederike H. , Tischler Benjamin , Bossennec Marion , Dominguez-Sola David , Bhagat Govind , Gu Wei , Basso Katia , Dalla-Favera Riccardo 
Published: May 2016

Key Points
FBXO11 loss in mice enhances GC B-cell formation and leads to increased BCL6 expression. FBXO11 inactivation, mimicking genetic alterations identified in human lymphomas, represents an alternative mechanism of BCL6 deregulation.
Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma
Authors: Assouline Sarit E. , Nielsen Torsten Holm , Yu Stephen , Alcaide Miguel , Chong Lauren , MacDonald David , Tosikyan Axel , Kukreti Vishal , Kezouh Abbas , Petrogiannis-Haliotis Tina , Albuquerque Marco , Fornika Daniel , Alamouti Sepideh , Froment Remi , Greenwood Celia M. T. , Oros Kathleen Klein , Camglioglu Errol , Sharma Ayushi , Christodoulopoulos Rosa , Rousseau Caroline , Johnson Nathalie , Crump Michael , Morin Ryan D. , Mann Koren K. 
Published: May 2016

Key Points
Panobinostat induces responses in 28% of patients with relapsed and refractory DLBCL that are typically durable off therapy. MEF2B mutations predicted for response whereas early increase in ctDNA abundance was a strong predictor of subsequent treatment failure.
Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis
Authors: Kastritis Efstathios , Papassotiriou Ioannis , Terpos Evangelos , Roussou Maria , Gavriatopoulou Maria , Komitopoulou Anna , Skevaki Chrysanthi , Eleutherakis-Papaiakovou Evangelos , Pamboucas Constantinos , Psimenou Erasmia , Manios Efstathios , Giannouli Stavroula , Politou Marianna , Gakiopoulou Harikleia , Papadopoulou Elektra , Stamatelopoulos Kimon , Tasidou Anna , Dimopoulos Meletios A. 
Published: May 2016

Key Points
Serum levels of VWF antigen are elevated in AL amyloidosis, reflecting endothelial dysfunction. High VWF levels predict for poor outcome in patients with cardiac involvement and discriminate high-risk patients even within stage IIIB.
A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping
Authors: Wen Qing , Kim Chang-Sik , Hamilton Peter W. , Zhang Shu-Dong 
Published: May 2016

Abstract
Background
Gene expression connectivity mapping has gained much popularity recently with a number of successful applications in biomedical research testifying its utility and promise. Previously methodological research in connectivity mapping mainly focused on two of the key components in the framework, namely, the reference gene expression profiles and the connectivity mapping algorithms. The other key component in this framework, the query gene signature, has been left to users to construct without much consensus on how this should be done, albeit it has been an issue most relevant to end users. As a key input to the connectivity mapping process, gene signature is crucially important in returning biologically meaningful and relevant results. This paper intends to formulate a standardized procedure for constructing high quality gene signatures from a user’s perspective.

Results
We describe a two-stage process for making quality gene signatures using gene expression data as initial inputs. First, a differential gene expression analysis comparing two distinct biological states; only the genes that have passed stringent statistical criteria are considered in the second stage of the process, which involves ranking genes based on statistical as well as biological significance. We introduce a “gene signature progression” method as a standard procedure in connectivity mapping. Starting from the highest ranked gene, we progressively determine the minimum length of the gene signature that allows connections to the reference profiles (drugs) being established with a preset target false discovery rate. We use a lung cancer dataset and a breast cancer dataset as two case studies to demonstrate how this standardized procedure works, and we show that highly relevant and interesting biological connections are returned. Of particular note is gefitinib, identified as among the candidate therapeutics in our lung cancer case study. Our gene signature was based on gene expression data from Taiwan female non-smoker lung cancer patients, while there is evidence from independent studies that gefitinib is highly effective in treating women, non-smoker or former light smoker, advanced non-small cell lung cancer patients of Asian origin.

Conclusions
In summary, we introduced a gene signature progression method into connectivity mapping, which enables a standardized procedure for constructing high quality gene signatures. This progression method is particularly useful when the number of differentially expressed genes identified is large, and when there is a need to prioritize them to be included in the query signature. The results from two case studies demonstrate that the approach we have developed is capable of obtaining pertinent candidate drugs with high precision.
Brain Radiation Information Data Exchange (BRIDE): integration of experimental data from low-dose ionising radiation research for pathway discovery
Authors: Karapiperis Christos , Kempf Stefan J. , Quintens Roel , Azimzadeh Omid , Vidal Victoria Linares , Pazzaglia Simonetta , Bazyka Dimitry , Mastroberardino Pier G. , Scouras Zacharias G. , Tapio Soile , Benotmane Mohammed Abderrafi , Ouzounis Christos A. 
Published: May 2016

Abstract
Background
The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies.

Results
We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology.

Conclusions
BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: <bride.azurewebsites.net>.
Time-Driven Activity-Based Costing: A Comparative Cost Analysis of Whole-Breast Radiotherapy Versus Balloon-Based Brachytherapy in the Management of Early-Stage Breast Cancer
Authors: Schutzer Matthew E. , Arthur Douglas W. , Anscher Mitchell S. 
Published: May 2016

Purpose: Value in health care is defined as outcomes achieved per dollar spent, and understanding cost is critical to delivering high-value care. Traditional costing methods reflect charges rather than fundamental costs to provide a service. The more rigorous method of time-driven activity-based costing was used to compare cost between whole-breast radiotherapy (WBRT) and accelerated partial-breast irradiation (APBI) using balloon-based brachytherapy. Materials and Methods: For WBRT (25 fractions with five-fraction boost) and APBI (10 fractions twice daily), process maps were created outlining each activity from consultation to post-treatment follow up. Through staff interviews, time estimates were obtained for each activity. The capacity cost rates (CCR), defined as cost per minute, were calculated for personnel, equipment, and physical space. Total cost was calculated by multiplying the time required of each resource by its CCR. This was then summed and combined with cost of consumable materials. Results: The total cost for WBRT was $5,333 and comprised 56% personnel costs and 44% space/equipment costs. For APBI, the total cost was $6,941 (30% higher than WBRT) and comprised 51% personnel costs, 6% space/equipment costs, and 43% consumable materials costs. The attending physician had the highest CCR of all personnel ($4.28/min), and APBI required 24% more attending time than WBRT. The most expensive activity for APBI was balloon placement and for WBRT was computed tomography simulation. Conclusion: APBI cost more than WBRT when using the dose/fractionation schemes analyzed. Future research should use time-driven activity-based costing to better understand cost with the aim of reducing expenditure and defining bundled payments.
Young Men With Cancer Experience Low Referral Rates for Fertility Counseling and Sperm Banking
Authors: Grover Natalie S. , Deal Allison M. , Wood William A. , Mersereau Jennifer E. 
Published: May 2016

Purpose: With improved cancer survival rates and the current trend of delaying parenthood, fertility is a growing issue among cancer patients. The purpose of this study was to evaluate the incidence of fertility counseling and sperm banking in reproductive-age male cancer patients and to assess factors that influence counseling and banking. Materials and Methods: Male patients ages 13 to 50 years who received a new cancer diagnosis from January 1, 2013, to May 1, 2015, and planned to initiate curative chemotherapy at our center were identified. Documentation of fertility counseling and sperm cryopreservation was abstracted from the medical record. Univariable and multivariable logistic regression modeling was used to examine variables associated with fertility counseling and sperm banking. Results: Of 201 patients who fit the study criteria, 59 (29%) received fertility counseling and 23 (11%) attempted sperm banking. All patients who banked sperm had documentation of fertility counseling. Younger patients were significantly more likely to be counseled, with mean ages of 27.4 and 40.4 years for counseled and noncounseled patients, respectively (P < .001). Among counseled patients, those with a lower median income (P = .038) or who had Medicaid or no insurance (P = .042) were less likely to bank sperm. In a multivariable logistic regression model, older age (5-year odds ratio, 0.61; P < .001) and presence of comorbidities (odds ratio, 0.15; P = .03) remained significantly associated with a lower counseling rate. Conclusion: There is a low rate of fertility counseling and referral for sperm banking in young men with cancer receiving chemotherapy. Further work is needed to develop interventions to improve fertility counseling rates and opportunities for sperm banking.
Danon disease – dysregulation of autophagy in a multisystem disorder with cardiomyopathy
Authors: Rowland Teisha J. , Sweet Mary E. , Mestroni Luisa , Taylor Matthew R. G. 
Published: May 2016

ABSTRACT
Danon disease is a rare, severe X-linked form of cardiomyopathy caused by deficiency of lysosome-associated membrane protein 2 (LAMP-2). Other clinical manifestations include skeletal myopathy, cognitive defects and visual problems. Although individuals with Danon disease have been clinically described since the early 1980s, the underlying molecular mechanisms involved in pathological progression remain poorly understood. LAMP-2 is known to be involved in autophagy, and a characteristic accumulation of autophagic vacuoles in the affected tissues further supports the idea that autophagy is disrupted in this disease. The LAMP2 gene is alternatively spliced to form three splice isoforms, which are thought to play different autophagy-related cellular roles. This Commentary explores findings from genetic, histological, functional and tissue expression studies that suggest that the specific loss of the LAMP-2B isoform, which is likely to be involved in macroautophagy, plays a crucial role in causing the Danon phenotype. We also compare findings from mouse and cellular models, which have allowed for further molecular characterization but have also shown phenotypic differences that warrant attention. Overall, there is a need to better functionally characterize the LAMP-2B isoform in order to rationally explore more effective therapeutic options for individuals with Danon disease.
Να ξανασκεφτούμε τις αξίες της κοινωνικής ασφάλισης
Authors: Στεργίου Άγγελος 
Published: May 2016

<p>Lately, the economy seems cut off from society. Instead of satisfying needs, it is devoted to an endless race for profit increase. Every attempt to recalibrate social insurance is subordinated to this ≪unified thought≫. In the absence of a social perspective, reform attempts view social insurance predominantly as a burden for the economy. The present article puts forward a social-centered approach for the reform of social security systems. In order to do so, it is important to focus once again on the values that brought about and strengthened social insurance.</p>
Keeping Your Enemies Closer: When Market Entry as an Alliance with Your Competitor Makes Sense
Authors: Cai C. Jeffrey , Raju Jagmohan S. 
Published: May 2016

We present an analytical framework of multimarket competition and supporting empirical analysis to explain why and when competing firms in an existing market may prefer an alliance entry over independent entry into a new market. Our findings suggest that an alliance entry is more profitable than an independent entry (i) when the new market is larger relative to the existing market, and (ii) when the competition in the existing market is stronger relative to the new market. We compare these key predictions with archival data from the regional shopping center industry in the United States and find that instances of alliance formation in this industry are consistent with our model-based predictions. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mksc.2016.0988 .