bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of Including Rain-Evaporative Cooling in the Initial Conditions on the Prediction of a Coastal Heavy Rainfall Event during TiMREX
Authors: Tu Chuan-Chi , Chen Yi-Leng , Chen Shu-Ya , Kuo Ying-Hwa , Lin Pay-Liam 
Published: September 2016

Abstract
A cycling run, which began 36 h before the model forecast, was employed to assimilate special Terrain-influenced Monsoon Rainfall Experiment (TiMREX) soundings, Global Telecommunications System (GTS) data, and Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) global positioning system (GPS) radio occultation (RO) refractivity profiles to improve the model initial conditions provided by the National Centers for Environmental Prediction (NCEP) Global Forecast System (GFS) to study a coastal, heavy rainfall event over southwestern Taiwan during 15–16 June 2008. The 36-h cycling run with data assimilation (DA_ALL_DATA run) has a positive impact on the depiction of subsynoptic flow in the model initial conditions at 1200 UTC 15 June, including the warm moist tongue and southwesterly monsoon flow over the open ocean. Furthermore, the cold pool caused by the evaporative cooling of antecedent rains and orographic blocking over southwestern Taiwan are better resolved in the nested high-resolution domain in the DA_ALL_DATA run as compared to the initial conditions provided by the NCEP GFS. As a result, the heavy rainfall along the southwestern coast and afternoon localized heavy rainfall over northern Taiwan are better predicted in the DA_ALL_DATA run.
Model sensitivity tests are also performed to diagnose the effects of terrain and rain-evaporative cooling on the intensity and depth of the cold pool and degree of orographic blocking on the southwesterly flow over southwestern Taiwan. It is apparent that including rain-evaporative cooling from antecedent rains and orographic effects in the model initial conditions are important to account for the predicted rainfall distribution of this coastal rainfall event.
Convection during the North American Monsoon across Central and Southern Arizona: Applications to Operational Meteorology
Authors: Rogers Jaret W. , Cohen Ariel E. , Carlaw Lee B. 
Published: September 2016

Abstract
This comprehensive analysis of convective environments associated with thunderstorms affecting portions of central and southern Arizona during the North American monsoon focuses on both observed soundings and mesoanalysis parameters relative to lightning flash counts and severe-thunderstorm reports. Analysis of observed sounding data from Phoenix and Tucson, Arizona, highlights several moisture and instability parameters exhibiting moderate correlations with 24-h, domain-total lightning and severe thunderstorm counts, with accompanying plots of the precipitable water, surface-based lifted index, and 0–3-km layer mixing ratio highlighting the relationship to the domain-total lightning count. Statistical techniques, including stepwise, multiple linear regression and logistic regression, are applied to sounding and gridded mesoanalysis data to predict the domain-total lightning count and individual gridbox 3-h-long lightning probability, respectively. Applications of these forecast models to an independent dataset from 2013 suggest some utility in probabilistic lightning forecasts from the regression analyses. Implementation of this technique into an operational forecast setting to supplement short-term lightning forecast guidance is discussed and demonstrated. Severe-thunderstorm-report predictive models are found to be less skillful, which may partially be due to substantial population biases noted in storm reports over central and southern Arizona.
Role of Landlords in Creating Healthy Homes: Section 8 Landlord Perspectives on Healthy Housing Practices
Authors: Polletta Valerie L. , Reid Margaret , Barros Eugene , Duarte Catherine , Donaher Kevin , Wensley Howard , Wolff Lisa 
Published: September 2016

Purpose: This article presents qualitative research findings of Section 8 landlord perceptions regarding healthy housing practices to inform landlord-focused initiatives. Approach or Design: Five focus groups were conducted with landlords. Setting: Boston, Massachusetts. Participants: Section 8 landlords participated in focus groups (n = 39). Method: Focus group transcripts were coded for key themes using a grounded theory approach. Results: Landlords’ primary challenges to creating a healthy housing environment included tenant behavior, financial burden, and policy enforcement; tenant safety and cost savings were seen as primary benefits. Conclusion: Landlords play a critical role in implementing healthy housing practices. Several opportunities exist to reduce barriers and capitalize on perceived benefits of implementing these practices, including increasing access to educational and financial resources.
When should I attempt my centrally administered summative assessments in the RANZCP competency-based training program?
Authors: Kealy-Bateman Warren , Kotze Beth , Lampe Lisa 
Published: September 2016

Objective: To provide information relevant to decision-making around the timing of attempting the centrally administered summative assessments in the Royal Australian and New Zealand College of Psychiatrists (RANZCP) 2012 Fellowship Program. Methods: We consider the new Competency-Based Fellowship Program of the RANZCP and its underlying philosophy, the trainee trajectory within the program and the role of the supervisor. The relationship between workplace-based and external assessments is discussed. The timing of attempting centrally administered summative assessments is considered within the pedagogical framework of medical competencies development. Results: Although successful completion of all the centrally administered summative assessments requires demonstration of a junior consultant standard of competency, the timing at which this standard will most commonly be achieved is likely to vary from assessment to assessment. There are disadvantages attendant upon prematurely attempting assessments, and trainees are advised to carefully consider the requirements of each assessment and match this against their current level of knowledge and skills. Conclusions: Trainees and supervisors need to be clear about the competencies required for each of the external assessments and match this against the trainee’s current competencies to assist in decision-making about the timing of assessments and planning for future learning.
Transference-Focused Psychotherapy in Australian psychiatric training and practice
Authors: Martin Louise , Lloyd Bonita , Cammell Paul , Yeomans Frank 
Published: September 2016

Objective: This article discusses Transference-Focused Psychotherapy, a contemporary evidence-based and manualised form of psychoanalytic psychotherapy for borderline personality disorder. Transference focused psychotherapy has evolved from decades of research in the object-relations approach developed by Professor Otto Kernberg and his collaborators. It is being adopted increasingly throughout North and South America and Europe, and this article explores the role its adoption might play in psychiatric training as well as public and private service provision contexts in Australia. Conclusions: Transference focused psychotherapy is readily applicable in a range of training, research and public and private service provision contexts in Australia. A numbers of aspects of current Australian psychiatric training and practice, such as the Royal Australian and New Zealand College of Psychiatrists advanced training certificate, and the Australian medicare schedule, make it especially relevant for this purpose.
Increasing resilience in adolescents: the importance of social connectedness in adventure education programmes
Authors: Scarf Damian , Hayhurst Jillian G , Riordan Benjamin C , Boyes Mike , Ruffman Ted , Hunter John A 
Published: September 2016

Objective: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents’ resilience and elucidate how social connectedness contributes to any increase. Method: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage. Perceived social support and sense of belonging were also measured at Time 2. A control group of adolescents, who did not take part in the voyage, also had their resilience assessed at two time points, 10 days apart. Result: Adolescents who participated in the AEP, but not those in the control group, displayed an increase in resilience from Time 1 to Time 2. Further, the increase in resilience was related to the adolescents’ sense of belonging, and this effect held when controlling for perceived social support. Conclusion: These findings demonstrate the positive impact AEPs have on adolescents’ resilience and a mechanism through which this occurs.
Gadopentetate but not gadobutrol accumulates in the dentate nucleus of multiple sclerosis patients
Authors: Schlemm Ludwig , Chien Claudia , Bellmann-Strobl Judith , Dörr Jan , Wuerfel Jens , Brandt Alexander U , Paul Friedemann , Scheel Michael 
Published: September 2016

Background: Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs). Objective: To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is associated with GBCA administration. Methods: In a cohort of 97 MS patients, the dentate-to-pons signal intensity ratio (DPSIR) was calculated for 265 consecutive T1-weighted magnetic resonance (MR) scans (including sessions with and without the administration of GBCA). Patients exclusively received either gadopentetate dimeglumine (Gd-DTPA, linear) or gadobutrol (Gd-BT-DO3A, macrocyclic). Results: In patients receiving Gd-DTPA, DPSIR increased significantly between the first and the last scan (+0.009, p < 0.001), and following magnetic resonance imaging (MRI) with Gd-DTPA administration as compared to following an MRI without Gd-DTPA administration (+0.005 vs −0.001; p = 0.022). Additionally, there was a positive linear relationship between the number of Gd-DTPA administrations and the increase in DPSIR ( p = 0.017). No DPSIR increase was observed after Gd-BT-DO3A administration. Conclusion: Dentate nucleus T1 hyperintensity in MS patients is associated with Gd-DTPA (but not Gd-BT-DO3A) administration, suggesting an alternative explanation for the association of T1 hyperintensity with disease duration and severity.
Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease
Authors: Bradbury Allison , Peterson David , Vite Charles , Chen Steven , Ellinwood N Matthew , Provenzale James 
Published: September 2016

Purpose The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain would show decreased fractional anisotropy (FA) values and increased apparent diffusion coefficient (ADC) and radial diffusivity (RD) values. Methods An 11-week-old Krabbe dog was euthanized after disease progression. The brain was removed and was placed in a solution of 10% formalin. MR imaging was performed and compared to the brain images of a normal dog that was similarly fixed post-mortem. Both brains were scanned using similar protocols on a 7 T small-animal MRI system. For each brain, maps of ADC, FA, and RD were calculated for 11 white-matter regions and five control gray-matter regions. Results Large decreases in FA values, increases in ADC values, and increases in RD (consistent with demyelination) values, were seen in white matter of the Krabbe brain but not gray matter. ADC values in gray matter of the Krabbe brain were decreased by approximately 29% but increased by approximately 3.6% in white matter of the Krabbe brain. FA values in gray matter were decreased by approximately 3.3% but decreased by approximately 29% in white matter. RD values were decreased by approximately 27.2% in gray matter but increased by approximately 20% in white matter. Conclusion We found substantial abnormalities of FA, ADC, and RD values in an ex vivo canine Krabbe brain.
Predictors of Revision Surgery After Primary Anterior Cruciate Ligament Reconstruction
Authors: Yabroudi Mohammad A. , Björnsson Haukur , Lynch Andrew D. , Muller Bart , Samuelsson Kristian , Tarabichi Majd , Karlsson Jón , Fu Freddie H. , Harner Christopher D. , Irrgang James J. 
Published: September 2016

Background: Revision anterior cruciate ligament (ACL) reconstruction surgery occurs in 5% to 15% of individuals undergoing ACL reconstruction. Identifying predictors for revision ACL surgery is of essence in the pursuit of creating adequate prevention programs and to identify individuals at risk for reinjury and revision. Purpose: To determine predictors of revision ACL surgery after failed primary ACL reconstruction. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 251 participants (mean age ± SD, 26.1 ± 9.9 years) who had undergone primary ACL reconstruction 1 to 5 years earlier completed a comprehensive survey to determine predictors of revision ACL surgery at a mean 3.4 ± 1.3 years after the primary ACL reconstruction. Potential predictors that were assessed included subject characteristics (age at the time of surgery, time from injury to surgery, sex, body mass index, preinjury activity level, return to sport status), details of the initial injury (mechanism; concomitant injury to other ligaments, menisci, and cartilage), surgical details of the primary reconstruction (Lachman and pivot shift tests under anesthesia, graft type, femoral drilling technique, reconstruction technique), and postoperative course (length of rehabilitation, complications). Univariate and multivariate logistic regression analyses were performed to identify factors that predicted the need for revision ACL surgery. Results: Overall, 21 (8.4%) subjects underwent revision ACL surgery. Univariate analysis showed that younger age at the time of surgery ( P = .003), participation in sports at a competitive level ( P = .023), and double-bundle ACL reconstruction ( P = .024) predicted increased risk of revision ACL surgery. Allograft reconstructions also demonstrated a trend toward greater risk of revision ACL surgery ( P = .076). No other variables were significantly associated with revision ACL surgery. Multivariate analysis revealed that revision ACL surgery was only predicted by age at the time of surgery and graft type (autograft vs allograft). Conclusion: The overall revision ACL surgery rate after primary unilateral ACL reconstruction was 8.4%. Univariate predictors of revision ACL reconstruction included younger age at the time of surgery, competitive baseline activity level, and double-bundle ACL reconstruction. However, multivariable logistic regression analysis indicated that age and reconstruction performed with allograft were the only independent predictors of revision ACL reconstruction.
Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins
Authors: Effelsberg Daniel , Cruz-Zaragoza Luis Daniel , Schliebs Wolfgang , Erdmann Ralf 
Published: September 2016

ABSTRACT
Peroxisomal proteins carrying a type 1 peroxisomal targeting signal (PTS1) are recognized by the well-conserved cycling import receptor Pex5p. The yeast YMR018W gene encodes a Pex5p paralog and newly identified peroxin that is involved in peroxisomal import of a subset of matrix proteins. The new peroxin was designated Pex9p, and it interacts with the docking protein Pex14p and a subclass of PTS1-containing peroxisomal matrix enzymes. Unlike Pex5p, Pex9p is not expressed in glucose- or ethanol-grown cells, but it is strongly induced by oleate. Under these conditions, Pex9p acts as a cytosolic and membrane-bound peroxisome import receptor for both malate synthase isoenzymes, Mls1p and Mls2p. The inducible Pex9p-dependent import pathway provides a mechanism for the oleate-inducible peroxisomal targeting of malate synthases. The existence of two distinct PTS1 receptors, in addition to two PTS2-dependent import routes, contributes to the adaptive metabolic capacity of peroxisomes in response to environmental changes and underlines the role of peroxisomes as multi-purpose organelles. The identification of different import routes into peroxisomes contributes to the molecular understanding of how regulated protein targeting can alter the function of organelles according to cellular needs.
Maternal complications in a geographically challenging and hard to reach district of Bangladesh: a qualitative study
Authors: Biswas Animesh , Dalal Koustuv , Abdullah Abu Sayeed Md , Gifford Mervyn , Halim MA 
Published: September 2016

Background: Maternal complications contribute to maternal deaths in developing countries. Bangladesh still has a high prevalence of maternal mortality, which is often preventable. There are some geographically challenging and hard to reach rural districts in Bangladesh and it is difficult to get information about maternal complications in these areas. In this study, we examined the community lay knowledge of possible pregnancy complications. We also examined the common practices associated with complications and we discuss the challenges for the community. Methods: The study was conducted in Moulvibazar of north east Bangladesh, a geographically challenged, difficult to reach district. Qualitative methods were used to collect the information. Pregnant women, mothers who had recently delivered, their guardians and traditional birth attendants participated in focus group discussions. Additionally, in-depth interviews were conducted with the family members. Thematic analyses were performed. Results: The study revealed that there is a lack of knowledge of maternal complications. In the majority of cases, the mothers did not receive proper treatment for maternal complications. There are significant challenges that these rural societies need to address: problems of ignorance, traditional myths and family restrictions on seeking better treatment. Moreover, traditional birth attendants and village doctors also have an important role in assuring appropriate, effective and timely treatment. Conclusions: The rural community lacks adequate knowledge on maternal complications. Reduction of the societal barriers including barriers within the family can improve overall practices. Moreover, dissemination of adequate information to the traditional birth attendant and village doctors may improve the overall situation, which would eventually help to reduce maternal deaths.
Breeding novel solutions in the brain: a model of Darwinian neurodynamics
Authors: Szilágyi András , Zachar István , Fedor Anna , de Vladar Harold P. , Szathmáry Eörs 
Published: September 2016

Background: The fact that surplus connections and neurons are pruned during development is well established. We complement this selectionist picture by a proof-of-principle model of evolutionary search in the brain, that accounts for new variations in theory space. We present a model for Darwinian evolutionary search for candidate solutions in the brain. Methods: We combine known components of the brain – recurrent neural networks (acting as attractors), the action selection loop and implicit working memory – to provide the appropriate Darwinian architecture. We employ a population of attractor networks with palimpsest memory. The action selection loop is employed with winners-share-all dynamics to select for candidate solutions that are transiently stored in implicit working memory. Results: We document two processes: selection of stored solutions and evolutionary search for novel solutions. During the replication of candidate solutions attractor networks occasionally produce recombinant patterns, increasing variation on which selection can act. Combinatorial search acts on multiplying units (activity patterns) with hereditary variation and novel variants appear due to (i) noisy recall of patterns from the attractor networks, (ii) noise during transmission of candidate solutions as messages between networks, and, (iii) spontaneously generated, untrained patterns in spurious attractors. Conclusions: Attractor dynamics of recurrent neural networks can be used to model Darwinian search. The proposed architecture can be used for fast search among stored solutions (by selection) and for evolutionary search when novel candidate solutions are generated in successive iterations. Since all the suggested components are present in advanced nervous systems, we hypothesize that the brain could implement a truly evolutionary combinatorial search system, capable of generating novel variants.
The role of resilience in rebuilding lives of injured veterans
Authors: Edward K-L. , Ousey K. 
Published: September 2016

The aim of this commentary is to discuss potential clinical implications of introducing resilience-building interventions into care for veterans who are living with a war wound. Some war veterans are expected to live with a wound upon discharge from an active military role and also to fit into civilian life. These lifestyle adjustments can tax the person's coping abilities and in that context may hinder successful adaptation. The experience of living with a wound or wounds, either acute or chronic, is connected to losses, including loss of mobility, loss of financial capacity (unable to work at times) and losses attached to changed social roles. Psychological stress is also a common experience for veterans returning to civilian life. Psychological stress is associated with impaired wound healing. Modern health practice is centred on symptom reduction and working with pathology, however, working with people's adaptive behaviours such as resilience has not been considered. Using the resilience model as a conceptual framework health-care professionals can engage with veterans towards resilience within the context of their personal experience of ill health. Using this contemporary framework for considering these aspects of care has the potential to facilitate resistance to stressors associated with being injured, possibly preventing quality-of-life impairments. Declaration of interest: There are no declarations of interest.