bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Mineral Density, 25‐OH Vitamin D and Inflammation in Patients with Psoriasis
Authors: Solak Berna , Dikicier Bahar Sevimli , Celik Hanife Duzgun , Erdem Teoman 
Published: February 2016

AbstractBackground/PurposeLow levels of vitamin D may play a role in the pathogenesis of psoriasis and is related to increased risk of osteoporosis. There are a few studies showing increased rate of osteoporosis in patients with psoriasis; however, none of them investigated impact of vitamin D levels and gender status together. We aimed to evaluate relationship between vitamin D and osteoporosis in psoriasis patients with an emphasis on gender difference.MethodsForty‐three psoriasis patients without arthritis and 41 healthy controls were enrolled. All patients were <50 years, and women were premenopausal. Participants were questioned about demographic features, sun exposure, regular physical exercise, and smoking status. The serum levels of 25‐OH vitamin D, calcium, phosphorus, C‐reactive protein, parathyroid hormone, total alkaline phosphatase, and sedimentation rate were measured. Body mass index was calculated. We determined the bone mineral density of the lumbar spine and femur using dual‐energy X‐ray absorptiometry.ResultsFemur neck Z score and lumbar spine total Z score were lower in psoriasis group than those of the control group. Additionally, total femoral Z score, lumbar spine total T, and Z scores were lower in female patients with psoriasis than female controls, whereas for male subjects there was not a remarkable difference between the groups. There was no significant difference between the two groups regarding vitamin D levels. The latter was significantly lower in psoriasis group than in controls for females; however, there was no significant difference between the two groups of males. Patients with psoriasis had higher CRP level and sedimentation rate, than control subjects. Female patients had also higher CRP level and sedimentation rate, than female controls, but there were no significant differences between male patients and controls.ConclusionAs osteoporosis has multifactorial etiology, psoriasis may be among the triggering or facilitating factors for osteoporosis particularly in psoriatic women via several mechanisms such as low blood level of vitamin D and increased inflammation.
Effects of meditation practice on spontaneous eyeblink rate
Authors: Kruis Ayla , Slagter Heleen A. , Bachhuber David R. W. , Davidson Richard J. , Lutz Antoine 
Published: February 2016

AbstractA rapidly growing body of research suggests that meditation can change brain and cognitive functioning. Yet little is known about the neurochemical mechanisms underlying meditation‐related changes in cognition. Here, we investigated the effects of meditation on spontaneous eyeblink rates (sEBR), a noninvasive peripheral correlate of striatal dopamine activity. Previous studies have shown a relationship between sEBR and cognitive functions such as mind wandering, cognitive flexibility, and attention–functions that are also affected by meditation. We therefore expected that long‐term meditation practice would alter eyeblink activity. To test this, we recorded baseline sEBR and intereyeblink intervals (IEBI) in long‐term meditators (LTM) and meditation‐naive participants (MNP). We found that LTM not only blinked less frequently, but also showed a different eyeblink pattern than MNP. This pattern had good to high degree of consistency over three time points. Moreover, we examined the effects of an 8‐week course of mindfulness‐based stress reduction on sEBR and IEBI, compared to an active control group and a waitlist control group. No effect of short‐term meditation practice was found. Finally, we investigated whether different types of meditation differentially alter eyeblink activity by measuring sEBR and IEBI after a full day of two kinds of meditation practices in the LTM. No effect of meditation type was found. Taken together, these findings may suggest either that individual difference in dopaminergic neurotransmission is a self‐selection factor for meditation practice, or that long‐term, but not short‐term meditation practice induces stable changes in baseline striatal dopaminergic functioning.
Core Competencies in Geriatric Dentistry Fellowship Programs: a Delphi Study
Authors: Hogue Christie M. , Andrade Allen D. , Ruiz Jorge G. , Gibson Gretchen 
Published: February 2016

ABSTRACTPurpose/ObjectivesThe healthcare workforce is challenged with preparing for the increasing number of older persons and complexities of their healthcare needs. Fellowship trained geriatric dentists are charged with the task of addressing the dental needs of this vastly growing cohort.The purpose of this study is to formulate a set of competencies for Geriatric Dental Fellowship Training Programs.MethodsThe Delphi technique—a series of three rounds of anonymous questionnaires to obtain the opinions of experts without bringing them together.ResultsIn Round 1, we proposed 45 competencies based on findings in previous literature. In Round 2, there were 19 respondents whose edits narrowed our list to 39 competencies proposed by the participants. In Round 3, based on group consensus we formulated a final list of 42 competencies.ConclusionUtilizing the Delphi process, a panel of geriatric dental experts identified a set of core competencies for curriculums in dental fellowship programs.
Towards engineering carboxysomes into C3 plants
Authors: Hanson Maureen R. , Lin Myat T. , Carmo‐Silva A. Elizabete , Parry Martin A.J. 
Published: February 2016

SummaryPhotosynthesis in C3 plants is limited by features of the carbon‐fixing enzyme Rubisco, which exhibits a low turnover rate and can react with O2instead ofCO2, leading to photorespiration. In cyanobacteria, bacterial microcompartments, known as carboxysomes, improve the efficiency of photosynthesis by concentratingCO2near the enzyme Rubisco. Cyanobacterial Rubisco enzymes are faster than those of C3 plants, though they have lower specificity towardCO2than the land plant enzyme. Replacement of land plant Rubisco by faster bacterial variants with lowerCO2specificity will improve photosynthesis only if a microcompartment capable of concentratingCO2can also be installed into the chloroplast. We review current information about cyanobacterial microcompartments and carbon‐concentrating mechanisms, plant transformation strategies, replacement of Rubisco in a model C3 plant with cyanobacterial Rubisco and progress toward synthesizing a carboxysome in chloroplasts.
Peridischarge prophylactic platelet transfusions after stem cell transplant: is a tranfusion trigger needed?
Authors: Meehan Kenneth R. , Sharma Purva , McKenna Dorothy R. , Dunbar Nancy M. 
Published: February 2016

BACKGROUNDWe examined the appropriateness of prophylactic peridischarge platelet (PLT) transfusions and the feasibility of lowering the prophylactic PLT transfusion threshold in transplant recipients within 24 hours of discharge at a National Cancer Institute–designated comprehensive cancer center.STUDY DESIGN AND METHODSFrom April 2011 to June 2014, each prophylactic PLT transfusion that was administered to transplant recipients within 24 hours of discharge was identified. Each transfusion was reviewed to identify the indication and to determine if the transfusion adhered to institutional guidelines.RESULTSOf the 187 transplant patients identified, 44 patients received a prophylactic PLT transfusion within 24 hours of discharge. Of these 44 patients, transfusions were administered to fulfill a PLT count of 20 × 109/L required for discharge (n = 25 patients), for the removal of a tunneled central venous catheter (n = 16 patients), for active bleeding (n = 1 patient), or due to active anticoagulation (n = 2 patients).CONCLUSIONSThe majority of PLT transfusions (95%) were appropriate, and only 5% were avoidable. If the prophylactic PLT transfusion threshold was decreased to 15 × 109/L from 20 × 109/L for central line removal and to fulfill discharge PLT count criteria, 41% of the currently appropriate PLT transfusions could have been avoided. These results suggest that a risk‐adapted method to select autologous transplant recipients for prophylactic PLT transfusions may be beneficial. A future study is needed to address this issue.
Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti‐Jra
Authors: Fujita Satoko , Kashiwagi Hirokazu , Tomimatsu Takuji , Ito Shoichi , Mimura Kazuya , Kanagawa Takeshi , Endo Masayuki , Miyoshi Tomomitsu , Okamura Yasushi , Tani Yoshihiko , Tomiyama Yoshiaki , Kimura Tadashi 
Published: February 2016

BACKGROUNDThe Jra antigen of JR blood group systems is located on ABCG2 and Jr(a–) subjects whose red blood cells (RBCs) lack ABCG2 have been identified mostly among the Japanese. Although anti‐Jra can cause fetal anemia, little is known regarding its mechanism.STUDY DESIGN AND METHODSWe reviewed clinical courses of all reported cases with fetal anemia due to anti‐Jra. We analyzed the ABCG2 expressions of cord RBCs at various gestational ages. We examined the effects of sera containing anti‐Jra from three pregnancies with fetal anemia or monoclonal anti‐Jra on erythropoiesis and phagocytosis. We also examined epitopes of anti‐Jra.RESULTSCase series suggested that the majority of fetal anemia with anti‐Jra may not be progressive in the later gestational ages. ABCG2 expression levels of cord RBCs were significantly higher than those of adults and neonates with high individual variation and gradually decreased with advancing gestational ages. Anti‐Jra did not significantly impact erythroid colony formation, although we detected a tendency toward the suppression of erythroid burst‐forming unit formation by anti‐Jra using feline marrow cells. Anti‐Jra did not induce phagocytosis of sensitized RBCs by monocytes. While many anti‐Jra recognized the same regions as a monoclonal anti‐ABCG2, 5D3, epitopes of anti‐Jra did not correlate with the incidence of fetal anemia.CONCLUSIONABCG2 expression levels in cord RBCs are higher than those of adults, and the change of ABCG2 expression in erythroid lineage cells may influence the clinical course of fetal anemia with anti‐Jra, although we could not detect significant effects of anti‐Jra on erythroid colony formation or phagocytosis.
Exploring the biophysical evidence that mammalian two‐pore channels are NAADP‐activated calcium‐permeable channels
Authors: Pitt Samantha J. , Reilly‐O'Donnell Benedict , Sitsapesan Rebecca 
Published: February 2016

AbstractNicotinic acid adenine dinucleotide phosphate (NAADP) potently releases Ca2+ from acidic intracellular endolysosomal Ca2+ stores. It is widely accepted that two types of two‐pore channels, termed TPC1 and TPC2, are responsible for the NAADP‐mediated Ca2+ release but the underlying mechanisms regulating their gating appear to be different. For example, although both TPC1 and TPC2 are activated by NAADP, TPC1 appears to be additionally regulated by cytosolic Ca2+. Ion conduction and permeability also differ markedly. TPC1 and TPC2 are permeable to a range of cations although biophysical experiments suggest that TPC2 is slightly more selective for Ca2+ over K+ than TPC1 and hence capable of releasing greater quantities of Ca2+ from acidic stores. TPC1 is also permeable to H+ and therefore may play a role in regulating lysosomal and cytosolic pH, possibly creating localised acidic domains. The significantly different gating and ion conducting properties of TPC1 and TPC2 suggest that these two ion channels may play complementary physiological roles as Ca2+‐release channels of the endolysosomal system.
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Draft Genome Sequence of the Fish Pathogen Mycobacterium pseudoshottsii Strain JCM15466, a Species Closely Related to M. marinum
Authors: Hikima Jun-ichi , Sakai Masahiro , Aoki Takashi , Takeyama Haruko , Hawke John , Mori Kazuki , Tashiro Kosuke , Kuhara Satoru 
Published: February 2016

ABSTRACTMycobacterium pseudoshottsiiis a slowly growing photochromogenic mycobacterium and fish pathogen isolated from wild marine fishes.M. pseudoshottsiiclosely resemblesM. marinum, which is a human and animal pathogen. Here, we report the draft genome sequence ofM. pseudoshottsiistrain JCM15466, originally isolated from striped bass,Morone saxatilis.
Draft Genome Sequences of Enterohemorrhagic Escherichia coli Encoding Extended-Spectrum Beta-Lactamases
Authors: Valat Charlotte , Goldstone Robert J. , Hirchaud Edouard , Haenni Marisa , Smith David G. E. , Madec Jean-Yves 
Published: February 2016

ABSTRACT

Extended-spectrum beta-lactamases (ESBLs) have rarely been observed among Shiga toxigenic
Escherichia coli
(STEC), and, to our best knowledge, only three ESBL-positive isolates of the enterohemorrhagic
E. coli
(EHEC) subpathotype have been reported. Here, we present the first draft genome sequences of two ESBL-positive EHEC isolates belonging to serotypes O111:H8 and O151:H16.
Draft Genome Sequence of a Klebsiella pneumoniae Carbapenemase-Positive Sequence Type 111 Pseudomonas aeruginosa Strain
Authors: Dotson Gabrielle A. ,   NISC Comparative Sequencing Program, Dekker John P. , Palmore Tara N. , Segre Julia A. , Conlan Sean 
Published: February 2016

ABSTRACT

Here, we report the draft genome sequence of a sequence type 111
Pseudomonas aeruginosa
strain isolated in 2014 from a patient at the NIH Clinical Center. This
P. aeruginosa
strain exhibits pan-drug resistance and harbors the
bla
KPC-2 gene, encoding the
Klebsiella pneumoniae
carbapenemase enzyme, on a plasmid.
Complete Genome Sequence of Lactobacillus acidophilus MN-BM-F01
Authors: Yang Lan , Chen Yun , Li Zhiwei , Shi Yudong , Li Zhouyong , Zhao Xiaohui 
Published: February 2016

ABSTRACT

Lactobacillus acidophilus
MN-BM-F01 was originally isolated from a traditional fermented dairy product in China. The characteristics of this bacterium are its low post-acidification ability and high acid-producing rate. Here, we report the main genome features of
L. acidophilus
MN-BM-F01.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase
Authors: D'Andrea Marco Maria , Giani Tommaso , Henrici De Angelis Lucia , Ciacci Nagaia , Gniadkowski Marek , Miriagou Vivi , Torricelli Francesca , Rossolini Gian Maria 
Published: February 2016

ABSTRACT

Proteus mirabilis
NO-051/03, representative of a multidrug-resistant clone expressing the CMY-16 AmpC-type β-lactamase and circulating in Europe since 2003, was sequenced by a MiSeq platform using a paired-end approach. The genome was assembled in 100 scaffolds with a total length of 4,197,318 bp. Analysis of the draft genome sequence revealed the presence of several acquired resistance determinants to β-lactams, aminoglycosides, phenicols, tetracyclines, trimethoprim, and sulfonamides, of one plasmid replicon, and of a type I-E clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein (Cas) adaptive immune system.
Draft Genome Sequences of Two Strains of Xanthomonas arboricola pv. celebensis Isolated from Banana Plants
Authors: Harrison James , Grant Murray R. , Studholme David J. 
Published: February 2016

ABSTRACT

We report here the annotated draft genome sequences of strains
Xanthomonas arboricola
pv. celebensis NCPPB 1832 and NCPPB 1630 (NCPPB, National Collection of Plant Pathogenic Bacteria), both isolated from
Musa
species in New Zealand. This will allow the comparison of genomes between phylogenetically distant xanthomonads that have independently converged with the ability to colonize banana plants.
Draft Genome Sequence of
Sphingomonas
sp. WG, a Welan Gum-Producing Strain
Authors: Li Hui , Feng Zhi-mei , Sun Ya-jie , Zhou Wan-long , Jiao Xue , Zhu Hu 
Published: February 2016

ABSTRACT

We report the draft genome sequence of
Sphingomonas
sp. WG, a high welan gum-producing strain with a yield of 33 g/L. The core of
wel
cluster for welan gum biosynthesis contained 24 coding sequences in the genome, which will provide the genetic information on welan gum production.
Draft Genome Sequence of Uncultured SAR324 Bacterium lautmerah10, Binned from a Red Sea Metagenome
Authors: Haroon Mohamed F. , Thompson Luke R. , Stingl Ulrich 
Published: February 2016

ABSTRACT
A draft genome of SAR324 bacterium lautmerah10 was assembled from a metagenome of a surface water sample from the Red Sea, Saudi Arabia. The genome is more complete and has a higher G+C content than that of previously sequenced SAR324 representatives. Its genomic information shows a versatile metabolism that confers an advantage to SAR324, which is reflected in its distribution throughout different depths of the marine water column.
Draft Genome Sequence of the Syntrophic Lactate-Degrading Bacterium Tepidanaerobacter syntrophicus JL
T
Authors: Matsuura Norihisa , Ohashi Akiko , Tourlousse Dieter M. , Sekiguchi Yuji 
Published: February 2016

ABSTRACT

We report here a high-quality draft genome sequence of the type strain (JL) of
Tepidanaerobacter syntrophicus
, an obligately anaerobic and moderately thermophilic bacterium, which is able to perform syntrophic lactate degradation with hydrogenotrophic methanogens. The genome comprises 2.43 Mb in 9 scaffolds, with a G+C content of 38.6%.
Draft Genome Sequence of Mycobacterium tuberculosis KT-0133, Isolated in South Korea
Authors: Kwon Taesoo , Han Seung Jung , Yoo Won Gi , Yun Mi-ran , Lee Sanghyun , Lee Jong Seok , Kim Dae-Won 
Published: February 2016

ABSTRACT

Here, we present the draft genome sequence of
Mycobacterium tuberculosis
KT-0133, which belongs to the Korean-Beijing family. This sequence will provide a new perspective on the evolution and accommodation of
M. tuberculosis
KT-0133 in human hosts.
Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child
Authors: Grass Gregor , Bierbaum Gabriele , Molitor Ernst , Götte Natascha , Antwerpen Markus 
Published: February 2016

ABSTRACT

We report the draft genome sequence of
Bacillus pumilus
strain Bonn associated with human skin infection.
B. pumilus
Bonn was isolated from a carbuncle-like necrotic site, resembling cutaneous anthrax, on the back of the hand of a 10-year-old child.
New South Wales Child Development Study (NSW-CDS): an Australian multiagency, multigenerational, longitudinal record linkage study
Authors: Carr Vaughan J , Harris Felicity , Raudino Alessandra , Luo Luming , Kariuki Maina , Liu Enwu , Tzoumakis Stacy , Smith Maxwell , Holbrook Allyson , Bore Miles , Brinkman Sally , Lenroot Rhoshel , Dix Katherine , Dean Kimberlie , Laurens Kristin R , Green Melissa J 
Published: February 2016

PurposeThe initial aim of this multiagency, multigenerational record linkage study is to identify childhood profiles of developmental vulnerability and resilience, and to identify the determinants of these profiles. The eventual aim is to identify risk and protective factors for later childhood-onset and adolescent-onset mental health problems, and other adverse social outcomes, using subsequent waves of record linkage. The research will assist in informing the development of public policy and intervention guidelines to help prevent or mitigate adverse long-term health and social outcomes.ParticipantsThe study comprises a population cohort of 87 026 children in the Australian State of New South Wales (NSW). The cohort was defined by entry into the first year of full-time schooling in NSW in 2009, at which time class teachers completed the Australian Early Development Census (AEDC) on each child (with 99.7% coverage in NSW). The AEDC data have been linked to the children's birth, health, school and child protection records for the period from birth to school entry, and to the health and criminal records of their parents, as well as mortality databases.Findings to dateDescriptive data summarising sex, geographic and socioeconomic distributions, and linkage rates for the various administrative databases are presented. Child data are summarised, and the mental health and criminal records data of the children's parents are provided.Future plansIn 2015, at age 11 years, a self-report mental health survey was administered to the cohort in collaboration with government, independent and Catholic primary school sectors. A second record linkage, spanning birth to age 11 years, will be undertaken to link this survey data with the aforementioned administrative databases. This will enable a further identification of putative risk and protective factors for adverse mental health and other outcomes in adolescence, which can then be tested in subsequent record linkages.
Development of a clinical prediction rule to improve peripheral intravenous cannulae first attempt success in the emergency department and reduce post insertion failure rates: the Vascular Access Decisions in the Emergency Room (VADER) study protocol
Authors: Carr Peter J , Rippey James C R , Cooke Marie L , Bharat Chrianna , Murray Kevin , Higgins Niall S , Foale Aileen , Rickard Claire M 
Published: February 2016

IntroductionPeripheral intravenous cannula (PIVC) insertion is one of the most common clinical interventions performed in emergency care worldwide. However, factors associated with successful PIVC placement and maintenance are not well understood. This study seeks to determine the predictors of first time PIVC insertion success in emergency department (ED) and identify the rationale for removal of the ED inserted PIVC in patients admitted to the hospital ward. Reducing failed insertion attempts and improving peripheral intravenous cannulation practice could lead to better staff and patient experiences, as well as improving hospital efficiency.Methods and analysisWe propose an observational cohort study of PIVC insertions in a patient population presenting to ED, with follow-up observation of the PIVC in subsequent admissions to the hospital ward. We will collect specific PIVC observational data such as; clinician factors, patient factors, device information and clinical practice variables. Trained researchers will gather ED PIVC insertion data to identify predictors of insertion success. In those admitted from the ED, we will determine the dwell time of the ED-inserted PIVC. Multivariate regression analyses will be used to identify factors associated with insertions success and PIVC failure and standard statistical validation techniques will be used to create and assess the effectiveness of a clinical predication rule.Ethics and disseminationThe findings of our study will provide new evidence to improve insertion success rates in the ED setting and identify strategies to reduce premature device failure for patients admitted to hospital wards. Results will unravel a complexity of factors that contribute to unsuccessful PIVC attempts such as patient and clinician factors along with the products, technologies and infusates used.Trial registration numberACTRN12615000588594; Pre-results.