bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor)
Authors: Zordan Martín A. , Papich Mark G. , Pich Ashley A. , Unger Katy M. , Sánchez Carlos R. 
Published: November 2016

Abstract
OBJECTIVE To determine the pharmacokinetics of a single dose of meloxicam after IM and oral administration to healthy lesser flamingos (Phoeniconaias minor) by use of a population approach.
ANIMALS 16 healthy captive lesser flamingos between 1 and 4 years of age.
PROCEDURES A single dose of meloxicam (0.5 mg/kg) was administered IM to each bird, and blood samples were collected from birds at 3 (n = 13 birds), 2 (2), or 1 (1) selected point between 0 and 13 hours after administration, with samples collected from birds at each point. After a 15-day washout period, the same dose of meloxicam was administered PO via a red rubber tube and blood samples were collected as described for IM administration. Pharmacokinetic values were determined from plasma concentrations measured by high-performance liquid chromatography.
RESULTS Plasma drug concentrations after IM administration of meloxicam reached a mean ± SD maximum value of 6.01 ± 3.38 μg/mL. Mean area under the concentration-versus-time curve was 17.78 ± 2.79 μg•h/mL, and mean elimination half-life was 1.93 ± 0.32 hours. Plasma concentrations after oral administration reached a mean maximum value of 1.79 ± 0.33 μg/mL. Mean area under the curve was 22.16 ± 7.17 μg•h/mL, and mean elimination half-life was 6.05 ± 3.53 hours.
CONCLUSIONS AND CLINICAL RELEVANCE In lesser flamingos, oral administration of meloxicam resulted in higher bioavailability and a longer elimination half-life than did IM administration, but the maximum plasma concentration was low and may be insufficient to provide analgesia in flamingos. Conversely, IM administration achieved the desired plasma concentration but would require more frequent administration.
Assessment of frailty in aged dogs
Authors: Hua Julie , Hoummady Sara , Muller Claude , Pouchelon Jean-Louis , Blondot Marc , Gilbert Caroline , Desquilbet Loic 
Published: November 2016

Abstract
OBJECTIVE To define a frailty-related phenotype—a clinical syndrome associated with the aging process in humans—in aged dogs and to investigate its association with time to death.
ANIMALS 116 aged guide dogs.
PROCEDURES Dogs underwent a clinical geriatric assessment (CGA) and were followed to either time of death or the study cutoff date. A 5-component clinical definition of a frailty phenotype was derived from clinical items included in a geriatric health evaluation scoresheet completed by veterinarians during the CGA. Univariate (via Kaplan-Meier curves) and multivariate (via Cox proportional hazards models) survival analyses were used to investigate associations of the 5 CGA components with time to death.
RESULTS 76 dogs died, and the median time from CGA to death was 4.4 years. Independent of age at the time of CGA, dogs that had ≥ 2 of the 5 components (n = 10) were more likely to die during the follow-up period, compared with those that had 1 or no components (adjusted hazard ratio, 3.9 [95% confidence interval, 1.4 to 10.9]). After further adjustments for subclinical or clinical diseases and routine biomarkers, the adjusted hazard ratio remained significant.
CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that signs of frailty appeared to be a risk factor for death in dogs. The concept of frailty in dogs requires further development.
IMPACT FOR HUMAN MEDICINE The concept of frailty, as defined for humans, seems transposable to dogs. Given that they share humans' environments and develop several age-related diseases similar to those in humans, dogs may be useful for the study of environmental or age-related risk factors for frailty in humans.
Effects of various antiplatelet drugs on ex vivo platelet activation induced by equine herpesvirus type 1
Authors: Hernandez Daniela , Yeo Wee Ming , Brooks Marjory B. , Ness Sally L. , Divers Thomas J. , Stokol Tracy 
Published: November 2016

Abstract
OBJECTIVE To evaluate the effects of treatment of horses with standard platelet inhibitors on ex vivo inhibition of platelet activation by equine herpesvirus type I (EHV-I).
ANIMALS II healthy adult horses.
PROCEDURES In a double-blinded, placebo-controlled crossover study, horses were treated orally for 5 days with theophylline (5 mg/kg, q 12 h), pentoxifylline (10 mg/kg, q 12 h), clopidogrel bisulfate (4 mg/kg, q 24 h), acetylsalicylic acid (20 mg/kg, q 24 h), or placebo. Horses received all treatments, each separated by a 3-week washout period. Platelet-rich plasma was prepared from citrated blood samples obtained before each treatment session and 4 hours after each final drug dose. Platelets were exposed to 2 EHV-I strains (at I plaque forming units/cell) or positive (thrombin-convulxin) and negative control substances for 10 minutes, then platelet activation was assessed by determining the percentages of P-selectin–positive platelets and platelet-derived microparticles (PDMPs; small events positive for annexin V) with flow cytometry. Platelet aggregation in response to 10μM ADP was also assessed.
RESULTS No significant differences in median percentages of P-selectin–positive platelets and PDMPs in EHV-I-exposed platelets were identified between measurement points (before and after treatment) for all drugs, nor were differences identified among drugs at each measurement point. Only clopidogrel significantly inhibited platelet aggregation in response to ADP in platelet-rich plasma samples obtained after that treatment session.
CONCLUSIONS AND CLINICAL RELEVANCE Treatment of horses with standard platelet inhibitors had no effect on EHV-I-induced platelet α-granule exteriorization or microvesiculation and release of PDMPs ex vivo, suggesting these drugs will not prevent platelet activation induced directly by EHV-I in vivo.
Assessment of in vitro release of carboplatin from six carrier media
Authors: Risselada Marije , Marcellin-Little Denis J. , Messenger Kristen M. , Griffith Emily , Davidson Gigi S. , Papich Mark G. 
Published: November 2016

Abstract
OBJECTIVE To investigate in vitro carboplatin release from 6 carrier media.
SAMPLE 6 carboplatin-containing carrier media.
PROCEDURES An in vitro release study was performed with 6 commercially available carrier media: a hemostatic gelatin sponge, a poloxamer copolymer gel, and 2 sizes (3 and 4.8 mm in diameter) of beads molded from each of 2 commercial calcium sulfate products. All carrier media contained 10 mg of carboplatin. Carrier media specimens were placed in 37°C PBS solution for 96 hours. Carboplatin concentrations in PBS solution were measured by use of high-performance liquid chromatography at 15 time points to calculate the amount and proportion of carboplatin released from each specimen.
RESULTS Peak release of carboplatin from the poloxamer copolymer gel and hemostatic gelatin sponge were achieved after 4 and 20 hours, respectively. Maximum release did not differ significantly between the poloxamer copolymer gel and hemostatic gelatin sponge, but both released significantly more carboplatin within 96 hours than did both of the commercial calcium sulfate products. The poloxamer copolymer gel released 99% of the carboplatin, and the hemostatic gelatin sponge released 68.5% of the carboplatin. Peak release of carboplatin from the calcium sulfate beads was not reached within 96 hours.
CONCLUSIONS AND CLINICAL RELEVANCE In this study, carboplatin release from the hemostatic gelatin sponge was incomplete. The poloxamer copolymer gel and hemostatic gelatin sponge released carboplatin rapidly in vitro, whereas calcium sulfate beads did not.
Security and biomechanical strength of three end-pass configurations for the terminal end of intradermal closures performed with unidirectional barbed suture material in dogs
Authors: Regier Penny J. , Smeak Daniel D. , McGilvray Kirk C. 
Published: November 2016

Abstract
OBJECTIVE To compare security of continuous intradermal suture lines closed by use of barbed suture with 3 end-pass configurations or without an end-pass configuration.
SAMPLE 40 full-thickness, 4-cm-long, parasagittal wounds in canine cadavers.
PROCEDURES Each continuous intradermal closure was terminated with 1 of 3 end-pass techniques or without an end-pass configuration (control group). A servohydraulic machine applied tensile load perpendicular to the long axis of the suture line. A load-displacement curve was generated for each sample; maximum load, displacement, stiffness, mode of construct failure, and load at first suture slippage at termination (ie, terminal end of the suture line) were recorded.
RESULTS Values for maximum load, displacement, and stiffness did not differ significantly among the 3 end-pass techniques, and load at first suture slippage at termination was not significantly different among the 4 groups. A 1-pass technique slipped in 5 of 9 samples; 3 of these 5 slips caused failure of wound closure. A 2-pass technique slipped in 3 of 9 samples, none of which caused failure of wound closure. Another 2-pass technique slipped in 4 of 10 samples; 2 of these 4 slips caused failure of wound closure. The control group had slippage in 10 of 10 samples; 9 of 10 slips caused failure of wound closure
CONCLUSIONS AND CLINICAL RELEVANCE An end-pass anchor was necessary to terminate a continuous intradermal suture line, and all 3 end-pass anchor techniques were suitable to prevent wound disruption. The 2-pass technique for which none of the suture slippages caused wound closure failure provided the most reliable configuration.
Comparison of desired radiographic advancement distance and true advancement distance required for patellar tendon–tibial plateau angle reduction to the ideal 90° in dogs by use of the modified Maquet technique
Authors: Pillard Paul , Livet Veronique , Cabon Quentin , Bismuth Camille , Sonet Juliette , Remy Denise , Fau Didier , Carozzo Claude , Viguier Eric , Cachon Thibaut 
Published: November 2016

Abstract
OBJECTIVE To evaluate the validity of 2 radiographic methods for measurement of the tibial tuberosity advancement distance required to achieve a reduction in patellar tendon–tibial plateau angle (PTA) to the ideal 90° in dogs by use of the modified Maquet technique (MMT).
SAMPLE 24 stifle joints harvested from 12 canine cadavers.
PROCEDURES Radiographs of stifle joints placed at 135° in the true lateral position were used to measure the required tibial tuberosity advancement distance with the conventional (AM) and correction (AE) methods. The MMT was used to successively advance the tibial crest to AM and AE. Postoperative PTA was measured on a mediolateral radiograph for each advancement measurement method. If none of the measurements were close to 90°, the advancement distance was modified until the PTA was equal to 90° within 0.1°, and the true advancement distance (TA) was measured. Results were used to determine the optimal commercially available size of cage implant that would be used in a clinical situation.
RESULTS Median AM and AE were 10.6 mm and 11.5 mm, respectively. Mean PTAs for the conventional and correction methods were 93.4° and 92.3°, respectively, and differed significantly from 90°. Median TA was 13.5 mm. The AM and AE led to the same cage size recommendations as for TA for only 1 and 4 stifle joints, respectively.
CONCLUSIONS AND CLINICAL RELEVANCE Both radiographic methods of measuring the distance required to advance the tibial tuberosity in dogs led to an under-reduction in postoperative PTA when the MMT was used. A new, more accurate radiographic method needs to be developed.
Systemic and ocular immune responses in cattle following intranasal vaccination with precipitated or partially solubilized recombinant Moraxella bovis cytotoxin adjuvanted with polyacrylic acid
Authors: Angelos John A. , Chigerwe Munashe , Edman Judy M. , Hess John F. 
Published: November 2016

Abstract
OBJECTIVE To evaluate changes in systemic and ocular antibody responses of steers following intranasal vaccination with precipitated or partially solubilized recombinant Moraxella bovis cytotoxin (MbxA).
ANIMALS 13 Angus steers with ages ranging from 318 to 389 days and weights ranging from 352 to 437 kg.
PROCEDURES Steers were assigned to receive 500 μg of a precipitated (MbxA-P; n = 5) or partially solubilized (MbxA-S; 5) recombinant MbxA subunit adjuvanted with polyacrylic acid. A control group (n = 3) received the adjuvant alone. Each steer received the assigned treatment (1 mL/nostril) on days 0 and 28. Serum and tear samples were collected on days 0 (before vaccination), 14, 28, 42, and 55. Changes in MbxA-neutralizing antibody titers and MbxA-specific IgG concentrations in serum and tears and changes in MbxA-specific IgA concentrations in tears were measured.
RESULTS Mean fold changes in MbxA-specific IgG concentration in serum and tears and MbxA-neutralizing antibody titer in tears for the MbxA-P group were significantly greater than those for the MbxA-S and control groups. Mean serum MbxA-neutralizing antibody titer did not differ among the 3 groups. Although the mean fold change in tear MbxA-specific IgA concentration differed significantly among the groups in the overall analysis, post hoc comparisons failed to identify any significant pairwise differences.
CONCLUSIONS AND CLINICAL RELEVANCE Systemic and ocular immune responses induced by intranasal administration of the MbxA-P vaccine were superior to those induced by the MbxA-S vaccine. Additional research is necessary to determine whether the MbxA-P vaccine can prevent naturally occurring infectious bovine keratoconjunctivitis.
Une nouvelle cicindèle de Thaïlande : Calochroa shozoi (Coleoptera Cicindelidae)
Authors: Naviaux Roger L. , Sawada Hirofumi 
Published: November 2016

A new cicindelid from Thailand : Calochroa shozoi (Coleoptera Cicindelidae)
Description of a new Calochroa recently collected in several localities of Chiang Mai province, north of Thailand. This species is closely allied to Calochroa bramani Dokhtouroff but may be distinguished by constant characters.
Présence d'Anodonta woodiana (Lea) en France (Mollusques Lamellibranches Unionidae)
Authors: Girardi H. , Ledoux Jean-Claude 
Published: November 2016

Occurrence of Anodonta woodiana (Lea) in France (Bivalvia Unionidae)
Anodonta (Pteranodon ) woodiana woodiana (Lea, 1834) is recorded for the first time from southern France, department of Bouches-du-Rhône. This east asiatic species, already introduced into eastern Europe, has been found in fish breeding bassins.
Sélection trophique chez les Hispinae (Coleoptera Chrysomelidae Cryptostoma)
Authors: Jolivet Pierre 
Published: November 2016

Trophic selection among Hispinae (Coleoptera Chrysomelidae Cryptostoma)
Many Hispinae larvae are mining inside the leaves of Gramineae or living freely or between appressed leaves of Palmae and other Monocots. Several genera feed on Dicots only. Generally, food choice is strict and most of the species are oligophagous.
CENTRAL ENGINE OF LATE-TIME X-RAY FLARES WITH INTERNAL ORIGIN
Authors: Mu Hui-Jun , Gu Wei-Min , Hou Shu-Jin , Liu Tong , Lin Da-Bin , Yi Tuan , Liang En-Wei , Lu Ju-Fu 
Published: November 2016

ABSTRACT
This work focuses on a sample of seven extremely late-time X-ray flares with peak time

, among which two flares can be confirmed as the late-time activity of central engine. The main purpose is to investigate the mechanism of such late-time flares based on the internal origin assumption. In the hyper-accreting black hole (BH) scenario, we study the possibility of two well-known mechanisms acting as the central engine to power such X-ray flares, i.e., the neutrino–antineutrino annihilation and the Blandford–Znajek (BZ) process. Our results show that the annihilation luminosity is far below the observational data. Thus, the annihilation mechanism cannot account for such late-time flares. For the BZ process, if the role of outflows is taken into consideration, the inflow mass rate near the horizon will be quite low such that the magnetic field will probably be too weak to power the observed X-ray flares. We therefore argue that, for the late-time flares with internal origin, the central engine is unlikely to be associated with BHs. On the contrary, a fast rotating neutron star with strong bipolar magnetic fields may be responsible for such flares.
THE EFFECTS OF SPATIAL SMOOTHING ON SOLAR MAGNETIC HELICITY PARAMETERS AND THE HEMISPHERIC HELICITY SIGN RULE
Authors: Ocker Stella Koch , Petrie Gordon 
Published: November 2016

ABSTRACT
The hemispheric preference for negative/positive helicity to occur in the northern/southern solar hemisphere provides clues to the causes of twisted, flaring magnetic fields. Previous studies on the hemisphere rule may have been affected by seeing from atmospheric turbulence. Using Hinode/SOT-SP data spanning 2006–2013, we studied the effects of two spatial smoothing tests that imitate atmospheric seeing: noise reduction by ignoring pixel values weaker than the estimated noise threshold, and Gaussian spatial smoothing. We studied in detail the effects of atmospheric seeing on the helicity distributions across various field strengths for active regions (ARs) NOAA 11158 and NOAA 11243, in addition to studying the average helicities of 179 ARs with and without smoothing. We found that, rather than changing trends in the helicity distributions, spatial smoothing modified existing trends by reducing random noise and by regressing outliers toward the mean, or removing them altogether. Furthermore, the average helicity parameter values of the 179 ARs did not conform to the hemisphere rule: independent of smoothing, the weak-vertical-field values tended to be negative in both hemispheres, and the strong-vertical-field values tended to be positive, especially in the south. We conclude that spatial smoothing does not significantly affect the overall statistics for space-based data, and thus seeing from atmospheric turbulence seems not to have significantly affected previous studies’ ground-based results on the hemisphere rule.
THE GINI COEFFICIENT AS A MORPHOLOGICAL MEASUREMENT OF STRONGLY LENSED GALAXIES IN THE IMAGE PLANE
Authors: Florian Michael K. , Li Nan , Gladders Michael D. 
Published: November 2016

ABSTRACT
Characterization of the morphology of strongly lensed galaxies is challenging because images of such galaxies are typically highly distorted. Lens modeling and source plane reconstruction is one approach that can provide reasonably undistorted images from which morphological measurements can be made, though at the expense of a highly spatially variable telescope point-spread function (PSF) when mapped back to the source plane. Unfortunately, modeling the lensing mass is a time- and resource-intensive process, and in many cases there are too few constraints to precisely model the lensing mass. If, however, useful morphological measurements could be made in the image plane rather than the source plane, it would bypass this issue and obviate the need for a source reconstruction process for some applications. We examine the use of the Gini coefficient as one such measurement. Because it depends on the cumulative distribution of the light of a galaxy, but not the relative spatial positions, the fact that surface brightness is conserved by lensing means that the Gini coefficient may be well preserved by strong gravitational lensing. Through simulations, we test the extent to which the Gini coefficient is conserved, including by effects due to PSF convolution and pixelization, to determine whether it is invariant enough under lensing to be used as a measurement of galaxy morphology that can be made in the image plane.
PROPERTIES OF SUPERSONIC EVERSHED DOWNFLOWS
Authors: Pozuelo S. Esteban , Rubio L. R. Bellot , Rodríguez J. de la Cruz 
Published: November 2016

ABSTRACT
We study supersonic Evershed downflows in a sunspot penumbra by means of high spatial resolution spectropolarimetric data acquired in the Fe i 617.3 nm line with the CRISP instrument at the Swedish 1 m Solar Telescope. Physical observables, such as Dopplergrams calculated from line bisectors and Stokes V zero-crossing wavelengths, and Stokes V maps in the far red-wing, are used to find regions where supersonic Evershed downflows may exist. We retrieve the line-of-sight velocity and the magnetic field vector in these regions using two-component inversions of the observed Stokes profiles with the help of the SIR code. We follow these regions during their lifetime to study their temporal behavior. Finally, we carry out a statistical analysis of the detected supersonic downflows to characterize their physical properties. Supersonic downflows are contained in compact patches moving outward, which are located in the mid- and outer penumbra. They are observed as bright, roundish structures at the outer end of penumbral filaments that resemble penumbral grains. The patches may undergo fragmentations and mergings during their lifetime; some of them are recurrent. Supersonic downflows are associated with strong and rather vertical magnetic fields with a reversed polarity compared to that of the sunspot. Our results suggest that downflows returning back to the solar surface with supersonic velocities are abruptly stopped in dense deep layers and produce a shock. Consequently, this shock enhances the temperature and is detected as a bright grain in the continuum filtergrams, which could explain the existence of outward-moving grains in the mid- and outer penumbra.
A VERY BRIGHT, VERY HOT, AND VERY LONG FLARING EVENT FROM THE M DWARF BINARY SYSTEM DG CVn
Authors: Osten Rachel A. , Kowalski Adam , Drake Stephen A. , Krimm Hans , Page Kim , Gazeas Kosmas , Kennea Jamie , Oates Samantha , Page Mathew , de Miguel Enrique , Novák Rudolf , Apeltauer Tomas , Gehrels Neil 
Published: November 2016

ABSTRACT
On 2014 April 23, the Swift satellite responded to a hard X-ray transient detected by its Burst Alert Telescope, which turned out to be a stellar flare from a nearby, young M dwarf binary DG CVn. We utilize observations at X-ray, UV, optical, and radio wavelengths to infer the properties of two large flares. The X-ray spectrum of the primary outburst can be described over the 0.3–100 keV bandpass by either a single very high-temperature plasma or a nonthermal thick-target bremsstrahlung model, and we rule out the nonthermal model based on energetic grounds. The temperatures were the highest seen spectroscopically in a stellar flare, at T

X
of 290 MK. The first event was followed by a comparably energetic event almost a day later. We constrain the photospheric area involved in each of the two flares to be >1020 cm2, and find evidence from flux ratios in the second event of contributions to the white light flare emission in addition to the usual hot, T ∼ 104 K blackbody emission seen in the impulsive phase of flares. The radiated energy in X-rays and white light reveal these events to be the two most energetic X-ray flares observed from an M dwarf, with X-ray radiated energies in the 0.3–10 keV bandpass of 4 × 1035 and 9 × 1035 erg, and optical flare energies at E

V
of 2.8 × 1034 and 5.2 × 1034 erg, respectively. The results presented here should be integrated into updated modeling of the astrophysical impact of large stellar flares on close-in exoplanetary atmospheres.