bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex disparities in global burden of gallbladder and biliary tract cancer: analysis of Global Burden of Disease study from 2010 to 2019
Authors: Dutta Priyata , Danpanichkul Pojsakorn , Suparan Kanokphong , Pang Yanfang , Rakwong Krittameth , Fine Michael R. , Wijarnpreecha Karn 
Published: October 2024

AbstractBackground and AimThe global burden of gallbladder and biliary tract cancer (GBTC) has been on the rise, making it a major public health concern. We aim to comprehensively analyze sex disparities in the temporal trends of GBTC incidence, mortality, and disability‐adjusted life years (DALYs) regionally and globally from 2010 to 2019.MethodsAge‐standardized rates of GBTC incidence, death, and DALYs were analyzed utilizing the Global Burden of Disease study 2019.ResultsFrom 2010 to 2019, the estimated annual percent change (APC) of the age‐standardized incidence rates (ASIRs) and age‐standardized disability‐adjusted life years (ASDALYs) due to GBTC globally decreased in both sexes (males, APC: −0.80%; APC: −1.00%) and (females, APC: −0.89%; APC: −0.96%). At the same time, age‐standardized death rates (ASDRs) decreased only in males (APC: −0.82%) and remained stable in females. By regions, ASIRs and ASDR increased in both sexes only in Southeast Asia (SEA) but decreased in the other regions. All regions had decreased ASDALYs except for an increase in ASDALYs for females only in the SEA region (APC: 0.41%), and males have a stable trend.ConclusionsOur study reveals substantial geographic variance in the burden of GBTC, specifically in the SEA region. Therefore, localized interventional methodologies must be undertaken to effectively address this global burden from GBTC.
A Highly Efficient and User‐Friendly Sensitive Skin Model on the Forearm
Authors: Zhang Jianhua , Liu Shichao , Guo Wenjiao , Li Na , Huang Yun 
Published: October 2024

ABSTRACTBackgroundSensitive skin is a worldwide skin problem, and its assessment of therapeutic efficacy traditionally relies on the facial stinging test. However, this test possesses certain limitations due to its restrictive application site, intense pain sensation, and adverse effects on physical appearance.ObjectiveThis study aimed to develop and evaluate a highly efficient and user‐friendly sensitive skin simulation model, which combines tape stripping and capsaicin testing on the forearm (FA‐TS‐CAT), as an alternative to the facial stinging test.MethodsA randomized, double‐blind, placebo‐controlled clinical trial was conducted involving 74 subjects. Skin redness (a* value), transepidermal water loss (TEWL), and self‐assessment questionnaires were collected at different time points for analysis.ResultsTape stripping 5 times and 10 min application of capsaicin test were identified as the optimal conditions for the FA‐TS‐CAT model. Consistent stimulation and natural recovery trends of a* value and TEWL were observed on both the FA‐TS‐CAT and facial capsaicin test (F‐CAT) models within 50 min. After the 4‐t‐butylcyclohexanol complex emulsion was applied, the a* value in the FA‐TS‐CAT model exhibited a soothing trend similar to the F‐CAT model, with a significantly reduced by 3.99‐fold and 3.28‐fold at T3 and T4 (p < 0.001), compared to the placebo. Notably, the test efficiency of the FA‐TS‐CAT model was threefold higher than that of the F‐CAT model, and subjects showed more willingness to participate in the FA‐TS‐CAT test (95.95% vs. 4.05%).ConclusionsThese results indicated the FA‐TS‐CAT is a highly efficient and user‐friendly model for sensitive skin, providing a reliable and valid method for clinical research in sensitive skin treatment.
Hepatitis Delta Coinfection Rates and All‐Cause Mortality Among Hepatitis B‐Infected Veterans in theUSA
Authors: Butt Adeel A. , Yan Peng , Iwnetu Rahel , Malik Amyn A. , Shaikh Obaid S. , O'Leary Jacqueline G. , Bedimo Roger 
Published: October 2024

ABSTRACTScreening for hepatitis D virus (HDV) is recommended for all individuals with hepatitis B virus (HBV) infection. Coinfected individuals experience more severe liver‐related outcomes. We determined the HDV testing and coinfection rates and all‐cause mortality among those infected with HBV. We used the US Department of Veterans Affairs (VA) healthcare system's national databases to identify individuals with HBV infection. We determined the proportion of individuals referred to gastroenterologists/hepatologists, or infectious diseases providers, and the proportion screened and tested positive for HDV. We calculated the HBV treatment rates, defined as ≥ 3 months of continuous prescription with an approved drug. Finally, we calculated all‐cause mortality stratified by HDV coinfection and HBV treatment status. Among 44,951 individuals with at least one positive HBsAg, HBeAg or HBV DNA test, 5964 (13.3%) were screened for HDV (180 [3.0%] tested positive), and 28,291 (62.9%) were referred to gastroenterology/hepatology or infectious diseases. Treatment for HBV was prescribed for 73 (40.5%) of HDV‐coinfected and 2425 (41.9%) HDV‐uninfected individuals. All‐cause mortality rate per 100 person‐years was lower among those without HDV coinfection (2.98 for untreated HBV, 2.53 for treated HBV;p < 0.001) compared with those with HDV coinfection (5.14 for untreated HBV, 3.0 for treated HBV;p = 0.02). Kaplan–Meier curves demonstrated a significantly higher mortality among HDV‐coinfected individuals who were not treated for HBV (log‐rankp < 0.0001). Screening rates for HDV among HBV‐infected individuals are suboptimal. While HDV coinfection is associated with higher all‐cause mortality, HBV treatment may confer a survival benefit.
A qualitative exploration of the COVID‐19 pandemic on health and nutrition behaviours during the first 1000 days in Sri Lanka
Authors: Schwendler Teresa R. , Senarath Upul , Jayawickrama Hiranya , Rowel Dhammica , Kawmi Noor , Abdulloeva Safina , De Silva Chithramalee , Kodish Stephen R. 
Published: October 2024

AbstractThis study sought to understand reported impacts of the COVID‐19 pandemic on maternal and child health and nutrition behaviours during the first 1000 days of life. This qualitative and participatory substudy was embedded within mixed methods formative research conducted during 2020–2022 across two urban, three rural and one estate sector site in Sri Lanka. Semi‐structured interviews among caregivers of children aged 6–23 months (n = 34), influencers of caregivers, such as health workers (n = 37), leaders (n = 10) and pregnant women (n = 20) were conducted. Participatory workshops (n = 14) triangulated interview findings. Interview data were analyzed to identify salient themes using Dedoose. Numerical data from voting conducted in workshops were summed and triangulated with interview data. Findings suggest that the COVID‐19 pandemic and imposed restrictions shaped maternal and child health and nutrition behaviours through a complex interplay of factors. Imposed restrictions and changes to the food system contributed to temporary unemployment for wage workers and reduced purchasing power to maintain food security for vulnerable households. While deciding whether to seek care, fears of infection prevented usual care‐seeking decisions. Also, reduced incomes and disrupted public transportation made transport to health care facilities for antenatal care services difficult. Once women reached facilities, medical services and quality of care were negatively impacted. Implementing expanded community‐based services during home visits focused on the first 1000 days and beyond was one effective strategy to maintain maternal and child health and nutrition during the early pandemic in Sri Lanka.
Efficacy of interventions aimed at reducing explicit and implicit weight bias in healthcare students: A systematic review and meta‐analysis
Authors: Jayawickrama Ravisha S. , Hill Briony , O'Connor Moira , Flint Stuart W. , Hemmingsson Erik , Ellis Lucy R. , Du Yaxing , Lawrence Blake J. 
Published: October 2024

SummaryWe conducted a systematic review and meta‐analysis to determine the efficacy of interventions aimed at reducing weight bias in healthcare students, and to explore factors that may impact intervention success. A systematic review and random‐effects meta‐analyses were conducted by including studies that examined the efficacy of weight bias reduction interventions for healthcare students. Of the 3463 journal articles and dissertations screened, 67 studies (within 64 records) met inclusion criteria, with 35 studies included in the meta‐analyses (explicit = 35, implicit [and explicit] = 10) and 32 studies included in the narrative synthesis (explicit = 34, implicit [and explicit] = 3). Weight bias interventions had a small but positive impact, g = −0.31 (95% CI = −0.43 to −0.19, p < 0.001), in reducing students' explicit weight bias but there was no intervention effect on implicit weight bias, g = −0.12 (95% CI = −0.26 to 0.02, p = 0.105). There was considerable heterogeneity in the pooled effect for explicit bias (I2 = 74.28, Q = 132.21, df = 34, p < 0.001). All subgroup comparisons were not significant (p > 0.05) and were unable to explain the observed heterogeneity. Narrative synthesis supported meta‐analytic findings. The small but significant reduction of explicit weight bias encourages the continued testing of interventions, irrespective of variation in individual intervention components. Contrarily, reductions in implicit weight bias may only be possible from a large societal shift in negative beliefs and attitudes held towards people living in larger bodies.
Increased visual alpha‐band activity during self‐paced finger tapping does not affect early visual stimulus processing
Authors: Gundlach C. , Müller M. M. 
Published: October 2024

AbstractAlpha‐band activity is thought to be involved in orchestrating neural processing within and across brain regions relevant to various functions such as perception, cognition, and motor activity. Across different studies, attenuated alpha‐band activity has been linked to increased neural excitability. Yet, there have been conflicting results concerning the consequences of alpha‐band modulations for early sensory processing. We here examined whether movement‐related alterations in visual alpha‐band activity affected the early sensory processing of visual stimuli. For this purpose, in an EEG experiment, participants were engaged in a voluntary finger‐tapping task while passively viewing flickering dots. We found extensive and expected movement‐related amplitude modulations of motor alpha‐ and beta‐band activity with event‐related‐desynchronization (ERD) before and during, and event‐related‐synchronization (ERS) after single voluntary finger taps. Crucially, while a visual alpha‐band ERS accompanied the motor alpha‐ERD before and during each finger tap, flicker‐evoked Steady‐State‐Visually‐Evoked‐Potentials (SSVEPs), as a marker of early visual sensory gain, were not modulated in amplitude. As early sensory stimulus processing was unaffected by amplitude‐modulated visual alpha‐band activity, this argues against the idea that alpha‐band activity represents a mechanism by which early sensory gain modulation is implemented. The distinct neural dynamics of visual alpha‐band activity and early sensory processing may point to distinct and multiplexed neural selection processes in visual processing.
Historical Foundations of Green Developmental Policies: Divergent Trajectories in United States and France
Authors: Ghosh Ritwick , Barral Stephanie , Guillet Fanny 
Published: October 2024

ABSTRACTIn recent years, many countries have adopted biodiversity offset policies to internalize the ecological impacts of land developments. Although national policies share the general principle of equalizing ecological harm with gain, there is substantial variation across programs regarding the institutional forms governing offsetting. In this paper, we compare biodiversity governance in the United States and France to reflect more broadly on the factors shaping divergent trajectories of green developmental policies. Both countries have some form of biodiversity offsetting in place, but the major fault line of difference is the more extensive use of market‐based instruments (MBI) in the United States. Using a historical lens, we argue that one important reason for this variation lies in the different legal‐institutional definitions of biodiversity. A narrower definition in the United States focused on individual species, versus a broader definition in France focused on ecosystems, has facilitated a more standardized biodiversity governance arrangement in the United States. Leveraging this standardization, biodiversity markets have expanded in the United States while similar efforts to institutionalize market mechanisms have struggled in France. The comparison allows us to draw insights into the challenges in greening economic development, particularly in showing how historical scientific, legal, and institutional structures condition policy outcomes.
Whole exome sequencing in patients with childhood‐onset systemic lupus erythematosus: Results from a Croatian national study
Authors: Sestan Mario , Arsov Todor , Kifer Nastasia , Frkovic Marijan , Grguric Danica , Ellyard Julia , Cook Matthew , Vinuesa Carola G. , Jelusic Marija 
Published: October 2024

AbstractThe purpose of this study was to identify new and low‐frequency gene variants using whole exome sequencing (WES) in patients with childhood‐onset systemic lupus erythematosus (cSLE), that may be involved in the pathogenesis of SLE. We performed WES on selected 17 trios (in some cases including other informative family members) in which the proband presented with severe, atypical clinical features, resistance to conventional therapy, a family pattern of occurrence and/or syndromic characteristics. After performing WES and analysis of gene variants, 17 novel and/or low‐frequency variants were identified in 7 patients. One variant was classified as pathogenic (KMT2D, NM_003482.3:c.8626delC, predicted to truncate the protein p.(Gln2876Serfs*34)) and two as likely pathogenic according to the American College of Medical Genetics and Genomics classification guidelines (ADAR, NM_001111.3:c.2815A>G, predicted to encode p.(Ile939Val); BLK, NM_001715.2:c.211G>A, predicted to encode p.(Ala71Thr)). The other variants remain of uncertain significance at this point of time. WES is an important diagnostic and research instrument, producing a growing list of likely genes and gene variants that may be of relevance in the pathogenesis of cSLE and potentially point to novel therapeutic targets.
It depends: Platform dependence, schedule control, and satisfaction among gig workers on Amazon's Mechanical Turk platform
Authors: Reynolds Jeremy , Kincaid Reilly 
Published: October 2024

AbstractUnderstanding the risks and rewards of gig work requires examining how gig workers themselves feel about their work and how work satisfaction may vary even among workers on the same gig platform. Platform dependence theory posits that financially disadvantaged workers who depend on gig work for essential income will be less satisfied, in part, because they are less able to work their preferred schedules. These predictions, however, have not been tested quantitatively. Using survey data from workers who do gig microtasks on Amazon's Mechanical Turk platform (MTurk), we examine how platform dependence, schedule mismatches (between preferred and actual work schedules), and work stress are related to work satisfaction. We find that all three factors are associated with lower satisfaction. Furthermore, we find support for a hypothesized mediating mechanism: platform dependence lowers satisfaction, in part, because it is associated with more mismatches between workers' preferred and actual schedules. We conclude by discussing reforms that could improve satisfaction for all microtask workers.
Intersectin‐1 enhances calcium‐dependent replenishment of the readily releasable pool of synaptic vesicles during development
Authors: Yang Yi‐Mei , Fekete Adam , Arsenault Jason , Sengar Ameet S. , Aitoubah Jamila , Grande Giovanbattista , Li Angela , Salter Eric W. , Wang Alex , Mark Melanie D. , Herlitze Stefan , Egan Sean E. , Salter Michael W. , Wang Lu‐Yang 
Published: October 2024

AbstractIntersectin‐1 (Itsn1) is a scaffold protein that plays a key role in coupling exocytosis and endocytosis of synaptic vesicles (SVs). However, it is unclear whether and how Itsn1 regulates these processes to support efficient neurotransmission during development. To address this, we examined the calyx of Held synapse in the auditory brainstem of wild‐type and Itsn1 mutant mice before (immature) and after (mature) the onset of hearing. Itsn1 was present in the pre‐ and postsynaptic compartments at both developmental stages. Loss of function of Itsn1 did not alter presynaptic action potentials, Ca2+ entry via voltage‐gated Ca2+ channels (VGCCs), transmitter release or short‐term depression (STD) induced by depletion of SVs in the readily releasable pool (RRP) in either age group. Yet, fast Ca2+‐dependent recovery from STD was attenuated in mature mutant synapses, while it was unchanged in immature mutant synapses. This deficit at mature synapses was rescued by introducing the DH–PH domains of Itsn1 into the presynaptic terminals. Inhibition of dynamin, which interacts with Itsn1 during endocytosis, had no effect on STD recovery. Interestingly, we found a developmental enrichment of Itsn1 near VGCCs, which may underlie the Itsn1‐mediated fast replenishment of the RRP. Consequently, the absence of Itsn1 in mature synapses led to a higher failure rate of postsynaptic spiking during high‐frequency synaptic transmission. Taken together, our findings suggest that Itsn1 translocation to the vicinity of VGCCs during development is crucial for accelerating Ca2+‐dependent RRP replenishment and sustaining high‐fidelity neurotransmission.
imageKey points
Itsn1 is expressed in the pre‐ and postsynaptic compartments of the calyx of Held synapse.
Developmental upregulation of vesicular glutamate transporter‐1 is Itsn1 dependent.
Itsn1 does not affect basal synaptic transmission at different developmental stages.
Itsn1 is required for Ca2+‐dependent recovery from short‐term depression in mature synapses.
Itsn1 mediates the recovery through its DH–PH domains, independent of its interactive partner dynamin.
Itsn1 translocates to the vicinity of presynaptic Ca2+ channels during development.
Itsn1 supports high‐fidelity neurotransmission by enabling rapid recovery from vesicular depletion during repetitive activity.
Cigarette Smoke Exposure Impairs Fracture Healing in a Rat Model: Preferential Impairment of Endochondral Over Membranous Healing
Authors: Reeves Russell A. , Wu Yongren , Hanna E. Lex , Holmes Robert E. , Chiaramonti Alexander M. , Nadeau Elizabeth K. , Lin Zilan , Westbrook Phillip A. , Hefter Glenn D. , Walsh Ryan C. , Barfield William R. , Pellegrini Vincent D. 
Published: October 2024

Abstract
Background: Cigarette smoking adversely affects fracture repair, causing delayed healing or nonunion rates twice those seen in nonsmokers. Purpose: We sought to investigate if cigarette smoke differentially affects intramembranous and endochondral healing of fractures. We hypothesize that healing via endochondral ossification will be preferentially impaired compared to intramembranous ossification. Methods: We utilized a bilateral femur fracture model in Sprague Dawley rats to examine effects of cigarette smoke exposure on healing of femur fractures, treated with either locked intramedullary nail or compression plating to induce endochondral and membranous ossification, respectively. Animals were exposed to tobacco smoke 30 days before and after surgery; evaluations included radiographs, histomorphometry, and micro-CT at 10 days, 1, 3, and 6 months postoperation, and biomechanical testing at 3 and 6 months. Results: Sixty-eight animals were randomized to control or exposure (two died perioperatively); 89% of femora achieved union when harvested at 3 or 6 months. Smoke exposure delayed cartilaginous callus formation and bone maturation in nailed fractures compared to plated fractures and controls in the same animals. Plated fractures in exposed animals exhibited little cartilage callus and healed like control animals. At 3 months, plated fractures were stiffer and stronger than nailed fractures in both groups. These differences vanished by 6 months. Conclusions: Plated fractures healed more rapidly and completely than nailed fractures under both control and smoke-exposed conditions. Clinical Relevance: Using compression plating instead of IM nailing for closed long bone fractures may lead to better outcomes in patients who smoke compared to current results with nailing.
Operational Modal Analysis of Self-Excited Vibrations in Milling Considering Periodic Dynamics
Authors: Zorlu Ayberk , Ahmadi Keivan , Ebrahimi-Tirtashi Ali 
Published: October 2024

Abstract
A new method is presented to identify the dynamics of regenerative chatter from measured process vibrations in milling. This method combines the synchronous once-per-revolution sampling of process vibrations with the operational modal analysis to estimate the Floquet multipliers of the delayed linear time-periodic dynamics in milling, all from the natural process vibrations without external excitation. The identified multipliers quantify vibration stability, enabling chatter prediction before it occurs. In addition to this, they can be used to calibrate physics-based chatter models based on vibration measurements solely within the stable region. The method’s accuracy in identifying Floquet multipliers is validated through extensive numerical simulations and two experimental case studies. The results show that chatter due to both Hopf and period-doubling bifurcations can be predicted from the process vibrations during stable cuts. Moreover, the experimental case studies demonstrate a vibration measurement system for implementing the presented method in standard milling operations and confirm its effectiveness in practice.
Adaptive Online Continual Learning for In-Situ Quality Prediction in Manufacturing Processes
Authors: Chen Mengfei , Sun Wenbo , Guo Weihong “Grace” 
Published: October 2024

Abstract
Manufacturing processes undergo continuous changes to meet various requirements, such as process/product changes and variations in tool/workpiece conditions, leading to mixed, heterogenous, or anomalous data. As a result, a quality prediction model trained from previous data may not perform well when new tasks emerge. To achieve in-time and accurate product quality prediction, it is crucial to develop a predictive method that adapts to variations in the manufacturing system, capable of learning from new tasks without forgetting previous ones and detecting unknown tasks. This study proposes a deep learning method integrated with continual learning for in-situ quality prediction that is capable of learning from new tasks without forgetting previous ones. To demonstrate this idea, deep convolutional neural networks (CNNs) are designed to analyze in-process sensor data, which consist of shared layers to capture the common underlying features across all tasks, and task-specific layers that capture specific characteristics of each individual task. To identify the task to which the incoming product belongs, a task prediction approach based on task relevancy using filter subspace distance is proposed. When new data come in, the model first identifies the task, followed by predicting the quality of the current product. The proposed method is demonstrated in two case studies, including quality prediction of the workpiece using acoustic emissions during the laser-induced plasma micromachining process and quality prediction of the product through thermal images during the hot stamping process.