bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccination during pregnancy: first line of defense for expecting mothers and vulnerable young infants
Authors: Bethancourt Casidhe-Nicole , Wang Tiffany L. , Bocchini Joseph A. 
Published: September 2017

Purpose of review
Maternal vaccination is a well-tolerated and effective way to protect mothers, their developing fetuses, and their young infants from infectious diseases. Although influenza vaccine and diphtheria, tetanus, and acellular pertussis (Tdap) vaccine are recommended for all pregnant women, uptake rates in the United States remain low. This review will focus on the rationale, scientific evidence, and perceptions of vaccination during pregnancy.

Recent findings
Recent studies show that administration of influenza and Tdap vaccines during pregnancy is well tolerated and provides protection to the pregnant woman, her fetus, and young infant. Studies have shown that many pregnant women look to their obstetricians to guide their prenatal care. A strong provider recommendation remains the greatest impetus to increase vaccine uptake. Both healthcare providers and expectant mothers should continue to be educated on the importance and safety of the influenza and Tdap vaccines during pregnancy.

Summary
Providers play a central role in advising patients and their families about the importance of maternal vaccination. The strong recommendation of providers and the availability of maternal vaccines in OB/GYN offices are keys to improve vaccine uptake. Attention must be paid to further development of intervention techniques that address unique barriers such as vaccine cost, storage concerns, and misinformation about vaccine safety.
Gastrointestinal Symptoms of Food Challenge‐proven Non‐IgE Cow's Milk Allergy Are Dissipated by Early School Age
Authors: Helin Noora , Kolho Kaija‐Leena , Qvist Erik , Mäkelä Mika , Merras‐Salmio Laura 
Published: September 2017

ABSTRACTObjectives:The aim of this study was to evaluate the current well‐being and dietary restrictions in children 6 years after food challenge‐confirmed diagnosis of non‐IgE cow's milk protein allergy, compared to peers with gastrointestinal symptoms but negative food challenge. This study aimed to evaluate the diagnostic process retrospectively.Methods:This is an Internet‐based survey for mothers whose children underwent 6 years ago the double‐blind, placebo‐controlled food challenge for cow's milk (CM) because of gastrointestinal symptoms causing suspicion of non‐IgE CM protein allergy. Concurrent dietary restrictions, overall well‐being, medical history, and retrospective views on the food challenge were queried using a study‐specific questionnaire, the Quality of life using PedsQL general score and parental stress with the Parenting Stress Index questionnaire.Result:Mothers of 42 children (23 girls), median age of 6.7 years (range 5.7–8.6), participated in the survey, the response rate was 70%. All children now consumed cow's milk protein. The only food restrictions reported were empirical lactose‐free diets in 7 children (17%). One‐third of the children in both groups were presently reported to have eating‐related issues such as picky eating. Quality of life was good and present parenting stress was average in both groups. The majority of the mothers (87%) felt positive or neutral about the food challenge performed in infancy.Conclusions:The non‐IgE CM allergy with gastrointestinal symptoms diagnosed in infancy was a transient condition with good outcome. At an early school age, nearly all children have a good quality of life and a regular diet. The use of the double‐blind, placebo‐controlled food challenge was well‐endorsed.
The Effect of Gluten‐free Diet on Clinical Symptoms and the Intestinal Mucosa of Patients With Potential Celiac Disease
Authors: Mandile Roberta , Discepolo Valentina , Scapaticci Serena , Del Vecchio Maria Rosaria , Maglio Maria Antonia , Greco Luigi , Troncone Riccardo , Auricchio Renata 
Published: September 2017

ABSTRACTIn this prospective study, we evaluated the effect of gluten‐free diet (GFD) in a cohort of 65 children with potential celiac disease. Patients received GFD for signs/symptoms (N = 47) or parents’ choice (N = 18). Most frequent signs/symptoms were low body mass index (36%), recurrent abdominal pain (34%), and diarrhea (19%). Of the 35/47 patients followed‐up on GFD, only 54% (19/35) showed a complete clinical response. In 9 of 65 patients an intestinal biopsy was also performed after at least 1 year of GFD. No significant differences were observed in terms of Marsh grade (P = 0.33), lamina propria CD25+ cells (P = 0.80), CD3+ (P = 0.9), and γδ+ (P = 0.59) intraepithelial lymphocytes density and intestinal anti‐TG2 deposits (P = 0.60). In conclusion, caution is necessary before attributing all symptoms to gluten in this condition.
Acute Upper Extremity Edema in a 10-Year-Old Girl as Presenting Symptom of a Rare Cancer
Authors: McCallin Tracy Elizabeth , Thampi Sheila , Eighmy Stephanie Michelle , Griffin Timothy Cameron , Sorrell April Deon 
Published: September 2017

Abstract
Acute onset upper extremity edema can pose a diagnostic challenge for the emergency physician, with conditions ranging from mild local allergic reactions to deep venous thrombosis to underlying life threatening conditions. We discuss a case of a 10-year-old female with upper extremity edema and the diagnostic considerations, which ultimately led to uncovering a malignant etiology. This case represents a rare presentation of her underlying diagnosis, anaplastic large cell lymphoma.
Point-of-Care Ultrasound Could Streamline the Emergency Department Workflow of Clinically Nonspecific Intussusception
Authors: Kim Jung Heon , Lee Jeong-Yong , Kwon Jae Hyun , Cho Hyung-Rae , Lee Jong Seung , Ryu Jeong-Min 
Published: September 2017

Objectives
The aim of this study was to evaluate whether point-of-care ultrasound (POCUS) for intussusception screening streamlines the workflow of clinically nonspecific intussusception (CNI), an intussusception presenting with only 1 manifestation of the classic triad, and/or vomiting.

Methods
We reviewed 274 consecutive children with intussusception, aged 6 years or younger, who visited a tertiary care hospital emergency department between May 2012 and April 2016. This period was dichotomized by May 2014 (the “PRE” and “POST” groups), starting point of implementation of the POCUS protocol for intussusception screening. All children with CNI who had positive results on or forwent POCUS underwent radiologist-performed ultrasound (US). We measured and compared emergency department length of stay (EDLOS), the sum of door-to-reduction and observation times, and the frequency of POCUS and positive US results between the 2 groups.

Results
Of 160 children with CNI, 93 visited the emergency department since May 2014. The POST group showed a shorter median EDLOS (856 vs 630 minutes, P < 0.001), door-to-reduction time (137 vs 111 minutes, P = 0.002), and observation time (700 vs 532 minutes, P < 0.001). The POST group had a higher frequency of POCUS (12% vs 60%, P < 0.001) with positive US results (33% vs 59%, P < 0.001). The PRE group had a higher frequency of severe bowel edema (16% vs 1%, P < 0.001). No significant differences were found in the severity, recurrence, admission, and surgery. One child had a false-negative result on POCUS.

Conclusions
Point-of-care ultrasound could streamline the workflow of CNI via decrease in EDLOS and unnecessary referrals for US.
Epigenetics and Precision Oncology
Authors: Werner Rachael J. , Kelly Andrew D. , Issa Jean-Pierre J. 
Published: September 2017

Abstract
Epigenetic alterations such as DNA methylation defects and aberrant covalent histone modifications occur within all cancers and are selected for throughout the natural history of tumor formation, with changes being detectable in early onset, progression, and ultimately recurrence and metastasis. The ascertainment and use of these marks to identify at-risk patient populations, refine diagnostic criteria, and provide prognostic and predictive factors to guide treatment decisions are of growing clinical relevance. Furthermore, the targetable nature of epigenetic modifications provides a unique opportunity to alter treatment paradigms and provide new therapeutic options for patients whose malignancies possess these aberrant epigenetic modifications, paving the way for new and personalized medicine. DNA methylation has proven to be of significant clinical utility for its stability and relative ease of testing. The intent of this review is to elaborate upon well-supported examples of epigenetic precision medicine and how the field is moving forward, primarily in the context of aberrant DNA methylation.
Population-based models of planning for palliative care in older people
Authors: Currow David C. , Phillips Jane , Agar Meera 
Published: September 2017

Purpose of review
Health service planning requires demographic, clinical, and health systems data and is unique to each health system. Planning for palliative care in older people must include patients and their carers. This review explores literature from the last 24 months.

Recent findings
The proportion of people living in skilled nursing facilities is increasing and many residents require quality palliative care. Simultaneously, the complexity of care for older people is also increasing. Systematic approaches to improving palliative care in these facilities have shown benefits that are cost-effective.
Although advance care planning is widely promoted, a randomized controlled trial failed to show the benefits seen in nonrandomized trials. This requires a reconceptualization of current programs that seek to increase uptake.
Caregivers take on complex decision-making which can be stressful. By contrast, patients are often very confident that the people who are close to them will make good decisions on their behalf.
Specific subgroups considered in this review include carers (and the challenges they face), the ‘oldest old’ and people with dementia.

Summary
Excellent research is being done to improve the care of older people with palliative care needs. Ultimately, how can key findings be incorporated into clinical care?
Single-cell transcriptomic profiling of progenitors of the oligodendrocyte lineage reveals transcriptional convergence during development
Authors: Marques Sueli , Vanichkina Darya , van Bruggen David , Floriddia Elisa M. , Munguba Hermany , Väremo Leif , Giacomello Stefania , Mendanha Falcão Ana , Meijer Mandy , Samudyata S , Codeluppi Simone , Björklund Åsa K. , Linnarsson Sten , Hjerling-Leffler Jens , Taft Ryan J. , Castelo-Branco Gonçalo 
Published: September 2017

SummaryPdgfra+oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different transcriptional oligodendrocyte (OL) states at adult stages. Here we present a bulk and single-cell transcriptomics resource providing insights on how transitions between these states occur. We show that E13.5Pdgfra+populations are not OPCs, exhibiting instead hallmarks of neural progenitors. A subset of these progenitors, which we refer as pre-OPCs, rewires their transcriptional landscape, converging into indistinguishable OPC states at E17.5 and post-natal stages. P7 brain and spinal cord OPCs present similar transcriptional profiles at the single-cell level, indicating that OPC states are not region-specific. Postnatal OPC progeny of E13.5Pdgfra+have electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves. In addition, lineage tracing indicates that a subset of E13.5Pdgfra+cells also originate cells of the pericyte lineage. In summary, our results indicate that embryonicPdgfra+cells are diverse and give rise at post-natal stages to distinct cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.
In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
Authors: Boot Arnoud , Huang Mi Ni , Ng Alvin W.T. , Ho Szu-Chi , Lim Jing Quan , Kawakami Yoshiiku , Chayama Kazuaki , Teh Bin Tean , Nakagawa Hidewaki , Rozen Steven G. 
Published: September 2017

AbstractBackground and aimsCisplatin reacts with DNA, and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, its mutational signature has not been delineated. We hypothesize that cisplatin’s mutational signature can serve as a biomarker to identify cisplatin mutagenesis in suspected secondary malignancies. Knowledge of which tissues are at risk of developing cisplatin-induced secondary malignancies could lead to guidelines for non-invasive monitoring for secondary malignancies after cisplatin chemotherapy.MethodsWe performed whole genome sequencing of 10 independent clones of cisplatin-exposed MCF-10A and HepG2 cells, and delineated the patterns of single- and dinucleotide mutations in terms of flanking sequence, transcription strand bias, and other characteristics. We used the mSigAct signature presence test and non-negative matrix factorization to search for cisplatin mutagenesis in hepatocellular carcinomas and esophageal adenocarcinomas.ResultsAll clones showed highly consistent patterns of single- and dinucleotide substitutions. The proportion of dinucleotide substitutions was high: 8.1% of single nucleotide substitutions were part of dinucleotide substitutions, presumably due to cisplatin’s propensity to form intra-and inter-strand crosslinks between purine bases in DNA. We identified likely cisplatin exposure in 9 hepatocellular carcinomas and 3 esophageal adenocarcinomas. All hepatocellular carcinomas for which clinical data were available and all esophageal cancers indeed had histories of cisplatin treatment.ConclusionsWe experimentally delineated the single- and dinucleotide mutational signature of cisplatin. This signature enabled us to detect previous cisplatin exposure in human hepatocellular carcinomas and esophageal adenocarcinomas with high confidence.
Isolation and identification of enteroviruses from sewage and sewage-contaminated water samples from Ibadan, Nigeria, 2012-2013
Authors: Adeniji Johnson Adekunle , Adewale Adetunji Oladapo , Faleye Temitope Oluwasegun Cephas , Adewumi Moses Olubusuyi 
Published: September 2017

AbstractIn 2010, we described sewage contaminated water (SCW) bodies that consistently yielded enteroviruses (EVs) in enterovirus surveillance (ES) sites in Lagos, Nigeria. By 2012, we demonstrated the presence and circulation of Wild Poliovirus 3 (WPV3) in these ES sites. Here we describe ES sites that consistently yield EVs in Ibadan metropolis southwest Nigeria.Twenty-five ES samples were collected by grab method from nine sites between October, 2012 and March, 2013. Samples were concentrated and four (RD, HEp2C, MCF-7 and L20B) different cell lines used for virus isolation from the concentrates. Isolates were subjected to RNA extraction, cDNA synthesis, PanEnterovirus 5l-UTR and VP1 assays. Unidentifiable isolates were further subjected to species-specific RT-PCR assays. Amplicons were sequenced, isolates identified and subjected to phylogenetic analysis.Twenty-five isolates were recovered from 8 (32%) of the 25 ES samples collected. Twenty-three of the isolates were identified as EVs by the PanEntero5l-UTR assay. Thirteen (57%) of the 23 EVs were positive for the VP1 assay, and identified as Coxsackievirus B3 (CVB3) (1 isolate), CVB6 (1 isolate), E6 (2 isolates), E7 (5 isolates), E11 (1 isolate), E12 (1 isolate) and E13 (2 isolates). None and 2 (25%) of the remaining isolates were positive for the EV-B and EV-C assays, respectively. The 2 EV-C positive enteroviruses were isolated on MCF-7.This study describes three very productive ES sites, and documents the presence of CVB3, CVB6, E6, E7, E11, E12 and, E13 in Ibadan, Nigeria. It shows that including other cell lines in EV isolation protocols can broaden the diversity of EV types recoverable.
Unique ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Authors: Rozman Grinberg Inna , Lundin Daniel , Hasan Mahmudul , Crona Mikael , Jonna Venkateswara Rao , Loderer Christoph , Sahlin Margareta , Markova Natalia , Borovok Ilya , Berggren Gustav , Hofer Anders , Logan Derek T , Sjöberg Britt-Marie 
Published: September 2017

AbstractRibonucleotide reductases (RNRs) are key enzymes in DNA synthesis and repair, with sophisticated allosteric mechanisms controlling both substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical-generating subunit. The ATP-cone in theLeewenhoekiella blandensisradical-generating subunit regulates activity via modifications of quaternary structure induced by binding of nucleotides. ATP induces enzymatically competent dimers, whereas dATP induces non-productive tetramers, resulting in different holoenzyme complexes. The tetramer forms solely by interactions between ATP-cones, as evidenced by a 2.45 Å crystal structure. We also present evidence for an MnIIIMnIVmetal center. In summary, lack of an ATP-cone domain in the catalytic subunit was compensated by evolutionary capture of the domain by the radical-generating subunit. Our findings present a novel opportunity for dATP-regulation of engineered proteins.
Capitalizing on Competition: An Evolutionary Model of Competitive Release in Metastatic Castration Resistant Prostate Cancer Treatment
Authors: West Jeffrey , Ma Yongqian , Newton Paul K. 
Published: September 2017

AbstractThe development of chemotherapeutic resistance resulting in tumor relapse is largely the consequence of the mechanism of competitive release of pre-existing resistant tumor cells selected for regrowth after chemotherapeutic agents attack the previously dominant chemo-sensitive population. We introduce a prisoners dilemma mathematical model based on the replicator of three competing cell populations: healthy (cooperators), sensitive (defectors), and resistant (defectors) cells. The model is shown to recapitulate prostate-specific antigen measurement data from three clinical trials for metastatic castration-resistant prostate cancer patients treated with 1) prednisone, 2) mitoxantrone and prednisone and 3) docetaxel and prednisone. Continuous maximum tolerated dose schedules reduce the sensitive cell population, initially shrinking tumor volume, but subsequently “release” the resistant cells to re-populate and re-grow the tumor in a resistant form. Importantly, a model fit of prostate data shows the emergence of a positive fitness cost associated with a majority of patients for each drug, without predetermining a cost in the model a priori. While the specific mechanism associated with this cost may be very different for each of the drugs, a measurable fitness cost emerges in each. The evolutionary model allows us to quantify responses to conventional therapeutic strategies as well as to design adaptive strategies.
The role of a predictive analytics project initiator in the integration of financial and operational forecasts
Authors: Huikku Jari , Hyvönen Timo , Järvinen Janne 
Published: September 2017

Purpose
The purpose of this paper is to investigate the initiation of accounting information system projects. Specifically, it examines the role of the predictive analytics (PA) project initiator in the integration of financial and operational sales forecasts.

Design/methodology/approach
The study uses a field study method to address the studied phenomenon in eight Finnish companies that have recently adopted PA systems. The data are primarily based on 19 interviews in the companies and five interviews with the PA consultants.

Findings
The authors found that initiators appear to play a major role regarding the degree of integration of financial and operational sales forecasts. The initiators from an accounting function have a tendency to pay more attention to the integration than the representatives from other functions, such as operations and sales.

Practical implications
The study also makes a practical contribution to companies in showing and discussing the important role of the accounting department as an initiator of a project if the target is to achieve a tight coupling of financial and operational forecast figures, i.e., “one set of numbers”.

Originality/value
Even though companies have increasingly adopted PA systems in recent years, we still know little about how the initiation affects the design of accounting information systems overall. The central contribution of the paper, therefore, is to show that if a PA project is initiated by the accounting department, data integration becomes more likely. It contributes also to the discussion related to the appropriateness of data integration in the context of forecasting.
Pensions and household consumption in rural China
Authors: Su Baozhong 
Published: September 2017

PurposeThe purpose of this paper is to examine the new rural social pension program’s effect on household consumption in rural China.Design/methodology/approachThe paper employs field data in Hebei Province and comprehensively applies the ordinary least squares regression model and the difference-in-difference matching method.FindingsThe findings show that participation in the Program may not obviously increase household consumption, rather it significantly inhibits the marginal propensity of young families’ consumption temporarily without an apparent impact on participating households’ consumption.Practical implicationsIn addition to maintain the stability of the basic system framework of the new rural social pension program and preserve or increase the value of the fund under the Program, dynamic adjustments to pension levels should be made as and when appropriate.Originality/valueThe study provides a new empirical evidence for the relationship between the new rural social pension program and consumption and gives insight into potential modifications and improvements to the Program.
Housing expenditure and home purchasing behaviors of rural-urban migrants in China
Authors: Tian Xiujuan , Hu Jiankun , Zhang Caiping , Zhao Yang 
Published: September 2017

Purpose
The purpose of this paper is to explore the housing behaviors of rural-urban migrant workers in China and the associated socioeconomic determinants.

Design/methodology/approach
The authors developed a model to empirically identify the effects of income in multi-dimension, destination expected to live in the future, local housing policy, and a set of individual characteristics on housing-related expenditure and home purchase of rural-urban migrants. A survey data collected by the Development Research Center of the State Council was employed.

Findings
The results showed that migrants’ expecting place to live in the future is a significant factor influencing their housing-related decisions. Including migrant workers in local housing security system of the host city could also significantly improve their incentive to purchase home. Income jointly with income stability affects migrants’ housing-related expenditure positively, but has an insignificant effect on home purchases in host city. The cost to buy home in city is still far away from migrant’s affordability is a likely explanation.

Originality/value
To the best of our knowledge, this is the first study aiming to investigate rural-urban migrants’ housing behavior in host city and to empirically identify the associated influencing factors.