bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro
Authors: Iqbal S.M. , Leonard C. , C. Regmi S. , De Rantere D. , Tailor P. , Ren G. , Ishida H. , Hsu CY. , Abubacker S. , Pang D. SJ. , T. Salo P. , Vogel H.J. , Hart D.A. , Waterhouse C.C. , Jay G.D , Schmidt T.A. , Krawetz R.J. 
Published: January 2016

AbstractProteoglycan 4 (PRG4/lubricin) is secreted by cells that reside in articular cartilage and line the synovial joint. Lubricin may play a role in modulating inflammatory responses through interaction with CD44. This led us to examine if lubricin could be playing a larger role in the modulation of inflammation/immunity through interaction with Toll-like receptors (TLRs). Human Embryonic Kidney (HEK) cells overexpressing TLRs 2, 4 or 5 and surface plasmon resonance were employed to determine if full length recombinant human lubricin was able to bind to and activate TLRs. Primary human synovial fibroblasts were also examined using flow cytometry and Luminex multiplex ELISA. A rat destabilization model of osteoarthritis (OA) was used to determine if lubricin injections were able to regulate pain and/or inflammationin vivo. Lubricin can bind to and regulate the activity of TLRs, leading to downstream changes in inflammatory signalling independent of HA. We confirmed these findingsin vivothrough intra-articular injections of lubricin in a rat OA model where the inhibition of systemic inflammatory signaling and reduction in pain were observed. Lubricin plays an important role in regulating the inflammatory environment under both homeostatic and tissue injury states.
A novel 2D silicon nano-mold fabrication technique for linear nanochannels over a 4 inch diameter substrate
Authors: Yin Zhifu , Qi Liping , Zou Helin , Sun Lei 
Published: January 2016

AbstractA novel low-cost 2D silicon nano-mold fabrication technique was developed based on Cu inclined-deposition and Ar+ (argon ion) etching. With this technique, sub-100 nm 2D (two dimensional) nano-channels can be etched economically over the whole area of a 4 inch n-type <100> silicon wafer. The fabricating process consists of only 4 steps, UV (Ultraviolet) lithography, inclined Cu deposition, Ar+ sputter etching and photoresist & Cu removing. During this nano-mold fabrication process, we investigated the influence of the deposition angle on the width of the nano-channels and the effect of Ar+ etching time on their depth. Post-etching measurements showed the accuracy of the nanochannels over the whole area: the variation in width is 10%, in depth it is 11%. However, post-etching measurements also showed the accuracy of the nanochannels between chips: the variation in width is 2%, in depth it is 5%. With this newly developed technology, low-cost and large scale 2D nano-molds can be fabricated, which allows commercial manufacturing of nano-components over large areas.
An interneuron progenitor maintains neurogenic potential in vivo and differentiates into GABAergic interneurons after transplantation in the postnatal rat brain
Authors: Wang Qi , Hong Peiwei , Gao Hui , Chen Yuntian , Yang Qi , Jiang Mei , Li Hedong 
Published: January 2016

AbstractDysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by transplantation strategy has proven to be a feasible and effective method to help revert the symptoms in several animal models. To develop methodology of generating transplantable GABAergic interneurons for therapy, we previously reported the isolation of a v-myc-induced GABAergic interneuron progenitor clone GE6 from embryonic ganglionic eminence (GE). These cells can proliferate and form functional inhibitory synapses in culture. Here, we tested their differentiation behavior in vivo by transplanting them into the postnatal rat forebrain. We found that GE6 cells migrate extensively in the neonatal forebrain and differentiate into both neurons and glia, but preferentially into neurons when compared with a sister progenitor clone CTX8. The neurogenic potential of GE6 cells is also maintained after transplantation into a non-permissive environment such as adult cortex or when treated with inflammatory cytokine in culture. The GE6-derived neurons were able to mature in vivo as GABAergic interneurons expressing GABAergic, not glutamatergic, presynaptic puncta. Finally, we propose that v-myc-induced human interneuron progenitor clones could be an alternative cell source of transplantable GABAergic interneurons for treating related neurological diseases in future clinic.
Liquid crystal phases of two-dimensional dipolar gases and Berezinskii-Kosterlitz-Thouless melting
Authors: Wu Zhigang , Block Jens K. , Bruun Georg M. 
Published: January 2016

AbstractLiquid crystals are phases of matter intermediate between crystals and liquids. Whereas classical liquid crystals have been known for a long time and are used in electro-optical displays, much less is known about their quantum counterparts. There is growing evidence that quantum liquid crystals play a central role in many electron systems including high temperature superconductors, but a quantitative understanding is lacking due to disorder and other complications. Here, we analyse the quantum phase diagram of a two-dimensional dipolar gas, which exhibits stripe, nematic and supersolid phases. We calculate the stiffness constants determining the stability of the nematic and stripe phases and the melting of the stripes set by the proliferation of topological defects is analysed microscopically. Our results for the critical temperatures of these phases demonstrate that a controlled study of the interplay between quantum liquid and superfluid phases is within experimental reach for the first time, using dipolar gases.
Evidence for redox sensing by a human cardiac calcium channel
Authors: Muralidharan Padmapriya , Cserne Szappanos Henrietta , Ingley Evan , Hool Livia 
Published: January 2016

AbstractIon channels are critical to life and respond rapidly to stimuli to evoke physiological responses. Calcium influx into heart muscle occurs through the ion conducting α1C subunit (Cav1.2) of the L-type Ca2+ channel. Glutathionylation of Cav1.2 results in increased calcium influx and is evident in ischemic human heart. However controversy exists as to whether direct modification of Cav1.2 is responsible for altered function. We directly assessed the function of purified human Cav1.2 in proteoliposomes. Truncation of the C terminus and mutation of cysteines in the N terminal region and cytoplasmic loop III-IV linker did not alter the effects of thiol modifying agents on open probability of the channel. However mutation of cysteines in cytoplasmic loop I-II linker altered open probability and protein folding assessed by thermal shift assay. We find that C543 confers sensitivity of Cav1.2 to oxidative stress and is sufficient to modify channel function and posttranslational folding. Our data provide direct evidence for the calcium channel as a redox sensor that facilitates rapid physiological responses.
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production
Authors: Oh Ji Eun , Lee Myeong Sup , Kim Young-Joon , Lee Heung Kyu 
Published: January 2016

AbstractType I interferon (IFN) interferes with virus replication, promotes antiviral responses and controls innate and adaptive immune responses to certain viruses. Recently, we reported that 2’–5’ oligoadenylate synthetase-like 1 (OASL1) negatively regulates type I IFN production by inhibiting the translation of the type I IFN-regulating master transcription factor, IRF7. Notably, while OASL1-deficient mice induce robust production of type I IFN and are resistant to systemic viral infection, the effects of OASL1 during localized viral infection has not been studied. To this end, we investigated the role of OASL1 during mucosal HSV-2 infection of the genital tract. Oasl1−/− mice exhibited better survival rates than wild type (WT) mice following intravaginal HSV-2 infection and suppressed virus replication more efficiently despite comparable recruitment of effector immune cells. Moreover, Ly6Chigh monocytes and not pDCs or other cell types, displayed enhanced production of type I IFNs in Oasl1−/− mice in response to HSV-2 infection. Furthermore, cytotoxic T cell responses including IFN-γ production were accelerated in Oasl1−/− mice after mucosal HSV-2 infection. Collectively, these results demonstrate that OASL1 deficiency promotes antiviral immunity against local mucosal viral infection and suggest that OASL1 could be a therapeutic target for treatment of HSV-2 infection of the genital mucosa.
Modified inflammation-based score as an independent malignant predictor in patients with pulmonary focal ground-glass opacity: a propensity score matching analysis
Authors: Jiang Long , Jiang Shanshan , Lin Yongbin , Yang Han , Zhao Zerui , Xie Zehua , Lin Yaobin , Long Hao 
Published: January 2016

AbstractPulmonary focal Ground-glass Opacities (fGGOs) would frequently be identified after widely implementation of low-dose computed tomography (LDCT) screening. Because of the high false-positive rate of LDCT, antibiotics should be regarded as advocates in clinical management for detected fGGOs. Retrospectively review consecutive patients with fGGOs between August 2006 and August 2012. Then, relative Glasgow prognostic score (GPS) were constructed in three different systems, traditional GPS system (tGPS), modified GPS system 1 (m1GPS) and modified GPS system 2 (m2GPS). Moreover, propensity score matching (PSM) was employed in balancing baseline covariates. After PSM, patients were matched and included in benign and malignant groups as 1:1 ratio. All reported parameters were balanced in both groups and no statistical differences could be detected. Finally, m1GPS exhibited remarkable different distribution between benign and malignant fGGOs. In detail, m1GPS 1 was more frequently observed in benign fGGOs nodules, while m1GPS 2 in malignant fGGOs nodules. Modified inflammation-based score was identified as an independent predictor of malignancies in patients with pulmonary fGGOs. Patients with m1GPS 1 were more likely to be benign fGGOs, while victims with m1GPS 2 more likely to be malignant.
Exploration of multiphoton entangled states by using weak nonlinearities
Authors: He Ying-Qiu , Ding Dong , Yan Feng-Li , Gao Ting 
Published: January 2016

AbstractWe propose a fruitful scheme for exploring multiphoton entangled states based on linear optics and weak nonlinearities. Compared with the previous schemes the present method is more feasible because there are only small phase shifts instead of a series of related functions of photon numbers in the process of interaction with Kerr nonlinearities. In the absence of decoherence we analyze the error probabilities induced by homodyne measurement and show that the maximal error probability can be made small enough even when the number of photons is large. This implies that the present scheme is quite tractable and it is possible to produce entangled states involving a large number of photons.
Overlapping illusions by transformation optics without any negative refraction material
Authors: Sun Fei , He Sailing 
Published: January 2016

AbstractA novel method to achieve an overlapping illusion without any negative refraction index material is introduced with the help of the optic-null medium (ONM) designed by an extremely stretching spatial transformation. Unlike the previous methods to achieve such an optical illusion by transformation optics (TO), our method can achieve a power combination and reshape the radiation pattern at the same time. Unlike the overlapping illusion with some negative refraction index material, our method is not sensitive to the loss of the materials. Other advantages over existing methods are discussed. Numerical simulations are given to verify the performance of the proposed devices.
High performance broadband photodetector using fabricated nanowires of bismuth selenide
Authors: Sharma Alka , Bhattacharyya Biplab , Srivastava A. K. , Senguttuvan T. D. , Husale Sudhir 
Published: January 2016

AbstractRecently, very exciting optoelectronic properties of Topological insulators (TIs) such as strong light absorption, photocurrent sensitivity to the polarization of light, layer thickness and size dependent band gap tuning have been demonstrated experimentally. Strong interaction of light with TIs has been shown theoretically along with a proposal for a TIs based broad spectral photodetector having potential to perform at the same level as that of a graphene based photodetector. Here we demonstrate that focused ion beam (FIB) fabricated nanowires of TIs could be used as ultrasensitive visible-NIR nanowire photodetector based on TIs. We have observed efficient electron hole pair generation in the studied Bi2Se3 nanowire under the illumination of visible (532 nm) and IR light (1064 nm). The observed photo-responsivity of ~300 A/W is four orders of magnitude larger than the earlier reported results on this material. Even though the role of 2D surface states responsible for high reponsivity is unclear, the novel and simple micromechanical cleavage (exfoliation) technique for the deposition of Bi2Se3 flakes followed by nanowire fabrication using FIB milling enables the construction and designing of ultrasensitive broad spectral TIs based nanowire photodetector which can be exploited further as a promising material for optoelectronic devices.
A novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signaling
Authors: Hsieh Tsung-Hua , Hsu Chia-Yi , Tsai Cheng-Fang , Chiu Chien-Chih , Liang Shih-Shin , Wang Tsu-Nai , Kuo Po-Lin , Long Cheng-Yu , Tsai Eing-Mei 
Published: January 2016

AbstractThe inhibition of β-catenin/LEF-1 signaling is an emerging strategy in cancer therapy. However, clinical targeted treatment of the β-catenin/LEF-1 complex remains relatively ineffective. Therefore, development of specific molecular targets is a key approach for identifying new cancer therapeutics. Thus, we attempted to synthesize a peptide (TAT-NLS-BLBD-6) that could interfere with the interaction of β-catenin and LEF-1 at nuclei in human breast cancer cells. TAT-NLS-BLBD-6 directly interacted with β-catenin and inhibited breast cancer cell growth, invasion, migration and colony formation as well as increased arrest of sub-G1 phase and apoptosis; it also suppressed breast tumor growth in nude mouse and zebrafish xenotransplantation models, showed no signs of toxicity and did not affect body weight. Furthermore, the human global gene expression profiles and Ingenuity Pathway Analysis software showed that the TAT-NLS-BLBD-6 downstream target genes were associated with the HER-2 and IL-9 signaling pathways. TAT-NLS-BLBD-6 commonly down-regulated 27 candidate genes in MCF-7 and MDA-MB-231 cells, which are concurrent with Wnt downstream target genes in human breast cancer. Our study suggests that TAT-NLS-BLBD-6 is a promising drug candidate for the development of effective therapeutics specific for Wnt/β-catenin signaling inhibition.
Comprehensive maternal serum proteomics identifies the cytoskeletal proteins as non-invasive biomarkers in prenatal diagnosis of congenital heart defects
Authors: Chen Lizhu , Gu Hui , Li Jun , Yang Ze-Yu , Sun Xiao , Zhang Li , Shan Liping , Wu Lina , Wei Xiaowei , Zhao Yili , Ma Wei , Zhang Henan , Cao Songying , Huang Tianchu , Miao Jianing , Yuan Zhengwei 
Published: January 2016

AbstractCongenital heart defects (CHDs) are the most common group of major birth defects. Presently there are no clinically used biomarkers for prenatally detecting CHDs. Here, we performed a comprehensive maternal serum proteomics assessment, combined with immunoassays, for the discovery of non-invasive biomarkers for prenatal diagnosis of CHDs. A total of 370 women were included in this study. An isobaric tagging for relative and absolute quantification (iTRAQ) proteomic approach was used first to compare protein profiles in pooled serum collected from women who had CHD-possessing or normal fetuses and 47 proteins displayed significant differential expressions. Targeted verifications were performed on 11 proteins using multiple reaction monitoring mass spectrometry (MRM-MS) and the resultant candidate biomarkers were then further validated using ELISA analysis. Finally, we identified a biomarker panel composed of 4 cytoskeletal proteins capable of differentiating CHD-pregnancies from normal ones [with an area under the receiver operating characteristic curve (AUC) of 0.938, P < 0.0001]. The discovery of cytoskeletal protein changes in maternal serum not only could help us in prenatal diagnosis of CHDs, but also may shed new light on CHD embryogenesis studies.
A Contrastive Study of 18th-Century Word-Lists
Authors: Fernández Rodríguez Rebeca 
Published: January 2016

Summary
At the end of the 18th century Russian Empress Catherine II sent a letter to Spanish King Charles III containing two lists. The first was a list of grammars and vocabularies of American and Asian languages, while the second was a lexical compilation to be translated into as many American and Philippine languages as possible by missionaries and Spanish civil servants. The so-called List no. 2, a matrix list of around 445 words, was translated into approximately fifty languages. These translations were sent to Spain but they never left the country. Although the matrix list in Spanish has already been published, a comparative study focusing on its different translations is still to be made. The compilation and translation of these lists – Pallas’ and List no. 2 – constitute one of the first large-scale projects in comparative linguistics. They were pioneers in their selection criteria, structure and methodology. This paper is a general overview of both the original matrix list (in Spanish) and the manuscripts containing the translations in more than fifty languages, which are to the present day preserved without being studied in the Archivo General de Indias in Seville and the Real Biblioteca in Madrid. In this paper, special attention will be paid to the compilation and translation strategies followed by the missionaries.
Mission, Politics and Linguistic Research
Authors: Rademaker Laura 
Published: January 2016

SummaryThis article investigates the ways local mission and national politics shaped linguistic research work in mid-20th century Australia through examining the case of the Church Missionary Society’s Angurugu Mission on Groote Eylandt in the Northern Territory and research into the Anindilyakwa language. The paper places missionary linguistics in the context of broader policies of assimilation and national visions for Aboriginal people. It reveals how this social and political climate made linguistic research, largely neglected in the 1950s (apart from some notable exceptions), not only possible, but necessary by the 1970s. Finally, it comments on the state of research into Aboriginal languages and the political climate of today. Until the 1950s, the demands of funding and commitment to a government policy of assimilation into white Australia meant that the CMS could not support linguistic research and opportunities for academic linguists to conduct research into Anindilyakwa were limited. By the 1960s, however, national consensus about the future of Aboriginal people and their place in the Australian nation shifted and governments reconsidered the nature of their support for Christian missions. As the ‘industrial mission’ model of the 1950s was no longer politically or economically viable, the CMS looked to reinvent itself, to find new ways of maintaining its evangelical influence on Groote Eylandt. Linguistics and research into Aboriginal cultures – including in partnership with secular academic agents – were a core component of this reinvention of mission, not only for the CMS but more broadly across missions to Aboriginal people. The resulting collaboration across organisations proved remarkably productive from a research perspective and enabled the continuance of a missionary presence and relevance. The political and financial limitations faced by missions shaped, therefore, not only their own practice with regards to linguistic research, but also the opportunities for linguists beyond the missionary fold. The article concludes that, in Australia, the two bodies of linguists – academic and missionary – have a shared history, dependent on similar political, social and financial forces.
Powerful quasar outflow in a massive disc galaxy at z ∼ 5
Authors: Curtis Michael , Sijacki Debora 
Published: January 2016

Abstract
There is growing observational evidence of high-redshift quasars launching energetic, fast outflows, but the effects that these have on their host galaxies is poorly understood. We employ the moving-mesh code AREPO to study the feedback from a quasar that has grown to ∼109 M⊙ by z ∼ 5 and the impact that this has on its host galaxy. Our simulations use a super-Lagrangian refinement technique to increase the accuracy with which the interface of the quasar-driven wind and the surrounding gas is resolved. We find that the feedback injected in these simulations is less efficient at removing gas from the galaxy than in an identical simulation with no super-Lagrangian refinement. This leads to the growth of a massive, rotationally supported, star-forming disc, co-existing with a powerful quasar-driven outflow. The properties of our host galaxy, including the kinematical structure of the gaseous disc and of the outflow, are in good agreement with current observations. Upcoming ALMA and JWST observations will be an excellent test of our model and will provide further clues as to the variance in properties of high-redshift quasar hosts.
The relationship between the outside financing and the quality of financial reporting: evidence from Iran
Authors: Kardan Behzad , Salehi Mahdi , Abdollahi Rahimeh 
Published: January 2016

Purpose
– This study aims to investigate the impact of outside financing (equity and debt financing) on the quality of financial reporting in Iran.

Design/methodology/approach
– Sample includes the companies listed on the Tehran Stock Exchange – 152 companies in a period of four years during 2010-2013. Data were analyzed by using multiple linear regressions with the benefits of the combined data.

Findings
– The results indicates that there is a positive relationship between the quality of financial reporting based on the qualitative characteristics of the theoretical principles of the Iranian Financial Accounting Standards Board and debt financing. Moreover, there is a negative relationship between the quality of financial reporting based on the Dechow and Dichev (2002) model and debt financing. Additionally, there is a negative relationship between the quality of financial reporting (based on the qualitative characteristics of the theoretical principles of the Iranian Financial Accounting Standards Board as well as the Dechow and Dichev models) and equity financing.

Originality/value
– Financial statements as the output of the accounting system has always been considered by the investors, the creditors and the government; nonetheless, its dependability in making decisions has always been doubted because of using the accrual principle in the calculation of the reported figure in the statements and, consequently, the possibility of being manipulated by the managers as well as the likelihood of conflict of interest among the managers and the shareholders.