bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological Profile Of Children With External Ventricular Drainage
Authors: Barreto de Almeida Leôncio Alane , Grilo Moreira Xavier Thaís , Oliveira Dantas Saionara Lenarda , Ladim Macêdo Cibério , Valente Braga Andrea , Do Nascimento Correia Silvia Virginia Pereira , Batista Sarmento de Oliveira Thaiany , Brito Gomes de Farias Hérika 
Published: March 2017

Objective: tracing the epidemiological profile, focused on infectious aspects, of children undergoing insertion of external ventricular drainage valve for the treatment of hydrocephalus.
Method: A retrospective, documentary and descriptive study of clinical and epidemiological approach with a quantitative analysis of the findings. The sample consisted of 53 children in a pediatric hospital of reference in the state of Paraiba in the period July 2009 to December 2014. For data analysis, non-parametric tests were used, and the chi-square test and Fisher test performed according to the statement.
Results: Among the 53 children who participated in our study, 49.1% (26) died. According to the causes found on the death certificate, 69.2% of the causes of death described relation to infection.
Conclusion: the high rates of CNS infections and other acquired infections, resulting in the deaths of children who underwent insertion of EVD valve, they are the result of a set of facts involving the care of a multidisciplinary team. The high incidence presented in the shunt study showed that changes and system remaining in the patient to a risk factor for infection.
Multiple Populations in NGC 1851: Abundance Variations and UV Photometric Synthesis in the Washington and HST/WFC3 Systems
Authors: Cummings Jeffrey D. , Geisler D. , Villanova S. 
Published: March 2017

Abstract
The analysis of multiple populations (MPs) in globular clusters (GCs), both spectroscopically and photometrically, is key in understanding their formation and evolution. The relatively narrow Johnson U, F336W, and Stromgren and Sloan u filters have been crucial in exhibiting these MPs photometrically, but in Paper I we showed that the broader Washington C filter can more efficiently detect MPs in the test case GC NGC 1851. Additionally, In Paper I we detected a double main sequence (MS) that has not been detected in previous observations of NGC 1851. We now match this photometry to NGC 1851's published RGB abundances and find that the two RGB branches observed in C generally exhibit different abundance characteristics in a variety of elements (e.g., Ba, Na, and O) and in CN band strengths, but no single element can define the two RGB branches. However, simultaneously considering [Ba/Fe] or CN strength with either [Na/Fe], [O/Fe], or CN strength can separate the two photometric RGB branches into two distinct abundance groups. Matches of NGC 1851's published SGB and HB abundances to the Washington photometry shows consistent characterizations of the MPs, which can be defined as an O-rich/N-normal population and an O-poor/N-rich population. Photometric synthesis for both the Washington C filter and the F336W filter finds that these abundance characteristics, with appropriate variations in He, can reproduce for both filters the photometric observations in both the RGB and the MS. This photometric synthesis also confirms the throughput advantages that the C filter has in detecting MPs.
Epidemiology of Skin Infections in Men's Wrestling: Analysis of 2009–2010 Through 2013–2014 National Collegiate Athletic Association Surveillance Data
Authors: Herzog Mackenzie M. , Fraser Melissa A. , Register-Mihalik Johna K. , Kerr Zachary Y. 
Published: March 2017

Context: Our knowledge of the current epidemiology of skin infections among wrestlers is limited.Objective: To analyze and report the epidemiology of skin infections among National Collegiate Athletic Association (NCAA) men's wrestling student-athletes during the 2009–2010 through 2013–2014 academic years.Design: Descriptive epidemiology study.Setting: Aggregate skin infection and exposure data collected by the NCAA Injury Surveillance Program.Patients or Other Participants: Collegiate men's wrestling student-athletes.Main Outcome Measure(s): All viral, bacterial, or fungal skin infections reported by athletic trainers at 17 NCAA programs were analyzed, providing 35 team-seasons of data. Skin infection rates per 10 000 athlete-exposures (AEs), rate ratios, skin infection proportions, and skin infection proportion ratios were calculated.Results: The athletic trainers reported 112 skin infections contracted by 87 student-athletes across 78 720 AEs. The overall skin infection rate was 14.23/10 000 AEs (95% confidence interval [CI] = 11.59, 16.86). Of the skin infections identified, 22.3% (n = 25) were recurrent skin infections. Most skin infections (65.2%) were attributable to 5 team-seasons (range, 11–19 infections). Most skin infections occurred during the regular season (n = 76, 67.9%), were identified during practice (n = 100, 89.3%), and resulted in ≥24 hours' time loss (n = 83, 74.1%). The rate for viral skin infections was 1.72 times the rate for bacterial skin infections (95% CI = 1.09, 2.72) and 2.08 times the rate for fungal skin infections (95% CI = 1.28, 3.39). Fungal skin infections more often resulted in time loss &lt;24 hours compared with all other skin infections (75.0% versus 12.5%; infection proportion ratio = 6.00; 95% CI = 3.30, 10.92).Conclusions: Our findings highlight the contagiousness of skin infections and suggest that skin infection rates may be attributable to high incidences among particular teams.
Between dwellings and doors: Spatial perspectives on preaching
Authors: Cilliers Johan H. 
Published: March 2017

Although many classical works on preaching, especially within the reformed tradition, would take as point of departure the question of understanding, that is, how to do exegesis of a biblical text in such a manner that it makes sense (is understandable) to present-day listeners of sermons, this article opts for an aesthetical approach, which does not exclude the question of intelligibility, but places it within aesthetical frameworks, such as our multi-sensing of space and time. Preaching, in my opinion, entails more than just speaking, hearing and (cognitive) understanding. It calls, inter alia, for a multi-sensory (re)discovery of space and time, within space and time. This article reflects specifically on the spatial dimension of preaching pertaining to experiences of being, or coming, home and, conversely, leaving home, that is, experiencing liminality, as not-being-at-home.
Candidate genes for alcohol dependence
Authors: Malhotra Savita , Basu Debasish , Khullar Madhu , Ghosh Abhishek , Chugh Neera 
Published: March 2017

Background & objectives:
Search for candidate genes for alcohol dependence (AD) has been inconsistent and inconclusive. Moreover, most of the research has been confined to a few specific ethnic groups. Hence, the aim of our study was to explore specific candidate genes for AD in north Indian male population.

Methods:
In this clinic-based genetic association study, 210 males with AD and 200 controls matched for age, gender and ethnicity were recruited from the clinic and the general population, respectively. Cases were diagnosed with Semi-structured Assessment for Genetics of Alcoholism-II (SSAGA-II). Single-nucleotide polymorphism genotyping was done by real-time quantitative-polymerase chain reaction (PCR) using Taq Man assay (ABI 7500) fast real-time PCR system.

Results:
Both at the genotypic level and at allelic frequency, Met158 variant of catechol-O-methyl transferase (COMT) showed significant increase in cases as compared to controls. The frequency of heterozygous genotype (A/G) of gamma-aminobutyric acid receptor A1 (GABRA1) was significantly lower in cases as compared to controls. Likewise, for GABRA2, the frequency of homozygous recessive genotype (G/G) was significantly higher in the control group. With respect to the 5-hydroxytryptamine (5HT) transporter long promoter region (5HTTLPR), cholinergic receptor muscarinic (CHRM2) and alcohol dehydrogenase 1B (ADH1B) genes, there was no significant difference between the cases and the controls. Aldehyde dehydrogenase (ALDH2) gene was found to be monomorphic in our study population.

Interpretation & conclusions:
Our study findings showed COMT polymorphism conferring risk and GABRA polymorphism as a protective genotype for Indian male with AD. Genes for alcohol metabolism, serotonin transporter and cholinergic receptor gene polymorphism were perhaps not contributory to AD for Indian population.
Prevalence & correlates of tobacco use among adolescents in Kerala, India
Authors: Jaisoorya T. S. , Beena K. V. , Beena M. , Jose Dalia C. , Ellangovan K. , Thennarasu K. , Benegal Vivek 
Published: March 2017

Background & objectives:
Most tobacco users who initiate its use during adolescence are likely to continue the use into adulthood and contribute to the 90 per cent of premature deaths among tobacco users. In this context the prevalence, patterns and correlates of tobacco use were studied among adolescent school students in Kerala, India.

Methods:
Total 7560 students from classes 8, 10 and 12, within the age group of 12-19 yr, across 73 schools in Ernakulam district, Kerala, India, selected by cluster random sampling, completed a self-administered questionnaire incorporating standardized instruments.

Results:
Of the 7350 valid questionnaires, the overall lifetime prevalence of tobacco use was 6.9 per cent (12.5% males and 1.2% females). The prevalence of tobacco use increased from 3.1 per cent at 12-13 yr to 15.1 per cent at 18-19 yr. The mean age of onset of tobacco use was 14.0±2.2 yr. The prevalence was higher among students from urban backgrounds, lower socio-economic status and those with part-time jobs. Tobacco users had significantly higher rates of use of alcohol (67.8 vs. 11%) and illicit drugs (33 vs. 6.1%). They had poorer academic performance (24.7 vs. 9.1%), more severe psychological distress (10.8 vs. 4.5%), suicidal attempts (10.2 vs. 3.5%), higher scores of ratings of attention deficit hyperactivity disorder (8.3 vs. 2.5%) and history of sexual abuse (12.5 vs. 3.8%).

Interpretation & conclusions:
The prevalence of tobacco use in adolescents reported in this study was relatively lower than those reported from other Indian States. However, it correlates with multiple negative outcomes suggesting a need to promote specific interventions to prevent adolescent tobacco use.
Evidence of apoptosis in right ventricular dysfunction in rheumatic mitral valve stenosis
Authors: Pande Shantanu , Tewari Prabhat , Agarwal Surendra K. , Agarwal Vikas , Agrawal Vinita , Chagtoo Megha , Majumdar Gauranga , Tewari Satyendra 
Published: March 2017

Background & objectives:
Right ventricular (RV) dysfunction is one of the causes of morbidity and mortality in valvular heart disease. The phenomenon of apoptosis, though rare in cardiac muscle may contribute to loss of its function. Role of apoptosis in RV in patients with rheumatic valvular heart disease is investigated in this study.

Methods:
Patients with rheumatic mitral valve stenosis formed two groups based on RV systolic pressure (RVSP) as RVSP <40 mmHg (group I, n=9) and RVSP ≥40 mmHg (group II, n=30). Patients having atrial septal defect (ASD) with RVSP <40 mmHg served as control (group III, n=15). Myocardial performance index was assessed for RV function. Real-time polymerase chain reaction was performed on muscle biopsy procured from RV to assess expression of pro-apoptotic genes (Bax, cytochrome c, caspase 3 and Fas) and anti-apoptotic genes (Bcl-2). Apoptosis was confirmed by histopathology and terminal deoxynucleotide-transferase-mediated dUTP nick end labelling.

Results:
Group II had significant RV dysfunction compared to group I (P=0.05) while caspase 3 (P=0.01) and cytochrome c (P=0.03) were expressed excessively in group I. When group I was compared to group III (control), though there was no difference in RV function, a highly significant expression of pro-apoptotic genes was observed in group I (Bax, P=0.02, cytochrome c=0.001 and caspase 3=0.01). There was a positive correlation between pro-apoptotic genes. Nuclear degeneration was present conforming to apoptosis in valve disease patients (groups I and II) while it was absent in patients with ASD.

Interpretation & conclusion:
Our findings showed evidence of apoptosis in RV of patients with valvular heart disease. Apoptosis was set early in the course of rheumatic valve disease even with lower RVSP, followed by RV dysfunction; however, expression of pro-apoptotic genes regressed.
Genetic characterization of human herpesvirus type 1
Authors: Bondre Vijay P. , Sankararaman Vasudha , Andhare Vijaysinh , Tupekar Manisha , Sapkal Gajanan N. 
Published: March 2017

Background & objectives:
Human herpes simplex virus 1 (HSV-1) is the most common cause of sporadic encephalitis in humans that contributes to >10 per cent of the encephalitis cases occurring worldwide. Availability of limited full genome sequences from a small number of isolates resulted in poor understanding of host and viral factors responsible for variable clinical outcome. In this study genetic relationship, extent and source of recombination using full-length genome sequence derived from a newly isolated HSV-1 isolate was studied in comparison with those sampled from patients with varied clinical outcome.

Methods:
Full genome sequence of HSV-1 isolated from cerebrospinal fluid (CSF) of a patient with acute encephalitis syndrome (AES) by inoculation in baby hamster kidney-21 (BHK-21) cells was determined using next-generation sequencing (NGS) technology. Phylogenetic analysis of the newly generated sequence in comparison with 33 additional full-length genomes defined genetic relationship with worldwide distributed strains. The bootscan and similarity plot analysis defined recombination crossovers and similarities between newly isolated Indian HSV-1 with six Asian and a total of 34 worldwide isolated strains.

Results:
Mapping of 376,332 reads amplified from HSV-1 DNA by NGS generated full-length genome of 151,024 bp from newly isolated Indian HSV-1. Phylogenetic analysis classified worldwide distributed strains into three major evolutionary lineages correlating to their geographic distribution. Lineage 1 containing strains were isolated from America and Europe; lineage 2 contained all the strains from Asian countries along with the North American KOS and RE strains whereas the South African isolates were distributed into two groups under lineage 3. Recombination analysis confirmed events of recombination in Indian HSV-1 genome resulting from mixing of different strains evolved in Asian countries.

Interpretation & conclusions:
Our results showed that the full-length genome sequence generated from an Indian HSV-1 isolate shared close genetic relationship with the American KOS and Chinese CR38 strains which belonged to the Asian genetic lineage. Recombination analysis of Indian isolate demonstrated multiple recombination crossover points throughout the genome. This full-length genome sequence amplified from the Indian isolate would be helpful to study HSV evolution, genetic basis of differential pathogenesis, host-virus interactions and viral factors contributing towards differential clinical outcome in human infections.
Functional Brain Stimulation in a Chronic Stroke Survivor With Moderate Impairment
Authors: Peters Heather T. , Pisegna Janell , Faieta Julie , Page Stephen J. 
Published: March 2017

AbstractOBJECTIVE. To determine the impact of transcranial direct current stimulation (tDCS) combined with repetitive, task-specific training (RTP) on upper-extremity (UE) impairment in a chronic stroke survivor with moderate impairment.METHOD. The participant was a 54-yr-old woman with chronic, moderate UE hemiparesis after a single stroke that had occurred 10 yr before study enrollment. She participated in 45-min RTP sessions 3 days/wk for 8 wk. tDCS was administered concurrent to the first 20 min of each RTP session.RESULTS. Immediately after intervention, the participant demonstrated marked score increases on the UE section of the Fugl–Meyer Scale and the Motor Activity Log (on both the Amount of Use and the Quality of Movement subscales).CONCLUSION. These data support the use of tDCS combined with RTP to decrease impairment and increase UE use in chronic stroke patients with moderate impairment. This finding is crucial, given the paucity of efficacious treatment approaches in this impairment level.
Correlation between Postoperative Area of High Autofluorescence in Macula and Visual Acuity after Macular Hole Closure
Authors: Zhang Peng , Shang Qingli , Ma Jingxue , Hao Yuhua , Ye Cunxi 
Published: March 2017

Purpose To determine the correlation between the preoperative basal diameter of macular hole, the postoperative area of high autofluorescence (AF) in macula, and visual acuity in full-thickness macular hole. Methods Forty-nine patients with full-thickness macular hole who underwent vitrectomy and C3F8 filling were reviewed. The preoperative diameter of macular hole, the 6 months postoperative area of high AF in macula if it existed, the length of inner segment/outer segment (IS/OS) defect, and visual acuity were obtained. The correlation between them was determined. Results At postoperative 6 months, the rate of high AF in macula was 63.3%. There were statistical differences between with and without high AF groups in postoperative best-corrected visual acuity (BCVA) (t = -2.751, p = 0.008), preoperative basal diameter of macular hole (t = -4.946, p = 0.00001), and postoperative length of IS/OS defect (t = -8.351, p<0.00001). Simple linear regression analysis showed high positive correlations between preoperative basal diameter of macular hole and area of high AF (p<0.00001, r = 0.893), postoperative length of IS/OS defect and area of high fundus AF (FAF) (p<0.00001, r = 0.779), and negative correlations between area of high AF and postoperative BCVA (p = 0.037, r = 0.375). There was low correlation between diameter of macular hole and postoperative BCVA (p = 0.112). Conclusions The preoperative basal diameter of macular hole and postoperative length of IS/OS defect decides the postoperative area of high AF in macula to some degree, and the postoperative area of high AF in macula can be an evaluating indicator for poor macular function recovery.
Robotic-Arm Assisted Total Hip Arthroplasty Results in Smaller Acetabular Cup Size in Relation to the Femoral Head Size: A Matched-Pair Controlled Study
Authors: Suarez-Ahedo Carlos , Gui Chengcheng , Martin Timothy J. , Chandrasekaran Sivashankar , Lodhia Parth , Domb Benjamin G. 
Published: March 2017

Purpose To compare the acetabular component size relative to the patient's native femoral head size between conventional THA (CTHA) approach and robotic-arm assisted THA (RTHA) to infer which of these techniques preserved more acetabular bone. Methods Patients were included if they had primary osteoarthritis (OA) and underwent total hip replacement between June 2008 and March 2014. Patients were excluded if they had missing or rotated postoperative anteroposterior radiographs. RTHA patients were matched to a control group of CTHA patients, in terms of preoperative native femoral head size, age, gender, body mass index (BMI) and approach. Acetabular cup size relative to femoral head size was used as a surrogate for amount of bone resected. We compared the groups according to 2 measures describing acetabular cup diameter ( c) in relation to femoral head diameter ( f): (i) c-f, the difference between cup diameter and femoral head diameter and (ii) ( c-f)/ f, the same difference as a fraction of femoral head diameter. Results 57 matched pairs were included in each group. There were no significant differences between groups for demographic measures, femoral head diameter, or acetabular cup diameter (p>0.05). However, measures (i) and (ii) did differ significantly between the groups, with lower values in the RTHA group (p<0.02). Conclusions Using acetabular cup size relative to femoral head size as an approximate surrogate measure of acetabular bone resection may suggest greater preservation of bone stock using RTHA compared to CTHA. Further studies are needed to validate the relationship between acetabular cup size and bone loss in THA.
Diffusion-weighted imaging in evaluating the efficacy of concurrent chemoradiotherapy in the treatment of non-small cell lung cancer
Authors: Xu Hai-Dong , Zhang Yu-Qin , Shen Wei-Yu , Mao Zheng-Chun 
Published: March 2017

Objective: To explore the predictive value of diffusion-weighted imaging (DWI) in evaluating the short-term efficacy of concurrent chemoradiotherapy (CCRT) in the treatment of patients with non-small cell lung cancer (NSCLC). Methods: A total of 192 patients with NSCLC were selected and treated with CCRT. Dynamic contrast-enhanced magnetic resonance imaging combined with DWI was performed on all patients before and after CCRT treatment. Correspondingly, apparent diffusion coefficient (ADC) values were recorded before treatment (ADCpre), during treatment (ADCmid), and after treatment (ADCpost). Tumor response was evaluated as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic power of quantitative DWI parameters in predicting the short-term efficacy of CCRT for patients with NSCLC. Results: There were 21 patients with CR, 82 with PR, 77 with SD, and 12 with PD. The ADCpre was negatively correlated with tumor regression rate, whereas ADCmid, ADCpost, and their respective change rates ∆ADCmid and ∆ADCpost were positively related to tumor regression rate. The ROC curve analysis suggested ADCpre = 1.38 × 10−3 mm2/s, ∆ADCmid = 14.14%, and ∆ADCpost = 20.39% as thresholds to predict the short-term efficacy of CCRT, with corresponding areas under the curve of 0.637, 0.743, and 0.752, respectively. Conclusions: These findings indicate that DWI provides promising predictive value in evaluating the short-term efficacy of CCRT in the treatment of patients with NSCLC.
Getting in the first word: Prosody and predicate initial sentences in Serbian
Authors: Diesing Molly , Zec Draga 
Published: March 2017

Second position clitics in Serbian are informally characterized in terms of their hosts which correspond to either the first word or the first phrase within some clitic positioning domain. Serbian is a free constituent order language, with a default SVO order, but with predicate initial orders in the presence of pro-drop or postposed subjects. Earlier proposals range from those in which first phrase positioning is taken to be syntactic and first word to be prosodic, with the initial prosodic word hosting the clitics (Zec and Inkelas 1990; Halpern 1995), to those which analyze both FirstPhrase and FirstWord as a unified syntactic phenomenon (Franks and Progovac 1994; Bošković 2001). While we argue for the relevance of prosody in first word placement, we shed new light on the scope of its role.This article is part of the Special Collection: Prosody and Constituent Structure