bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural adaptation and primary approbation of the Russian version of Posttraumatic Growth and Depreciation Inventory — Expanded version
Authors: Shishkova Alexandra M. , Bocharov Victor V. , Elizaveta Tsygankova S. , Chernaya Yulia S. 
Published: October 2024

Numerous studies suggest that caring for someone with a chronic disease is often associated with the various negative consequences for the patient’s informal caregivers. At the same time, positive changes caused by the stress influence of patient’s disease can be also noted. For example, the so-called posttraumatic growth. Currently, there is a lack of assessment tools in domestic psychology, that allow to investigate the relation between constructive (developmental) and destructive aspects of the relative’s mental response in a situation of chronic illness of a loved one.The aim of this work was to carry out cross-cultural adaptation and primary approbation of the Posttraumatic Growth and Depreciation Inventory — Expanded version (PTGDI-X). Primary approbation was performed on a focus group of relatives of patients with cerebral pathology (n = 61, mean age 51,2 [SD = 15,3] years). Convergent and discriminant validity of the PTGDI-X assessed using World Assumption Scale (WAS), Symptom Checklist-90-Revised (SCL-90-R), Level of Relatives’ Emotional Burnout Questionnaire (LREB). In addition, a specially adapted for the research Burden questionnaire was used.The analysis revealed good psychometric characteristics of the PTGDI-X Russian version in terms of: internal subscales consistency (Cronbach’s α coefficients varied from 0,73 to 0,86), internal and external construct validity
Four-tract tractography: multiparametric direct targeting of the dentatorubrothalamic tract
Authors: Seas Andreas , Hon Katrina , Chung David , Todd Lynne , Shah Bhavya R. , Lad Shivanand P. , Harward Stephen 
Published: October 2024

This video article presents a case study of a 70-year-old male with medically refractory essential tremor treated with magnetic resonance–guided focused ultrasound (MRgFUS). Following an initial successful ablation of the right thalamus, the patient underwent left-sided thalamotomy. After two tractography-guided sonications, the authors observed a significant reduction in his right-hand tremor with no immediate side effects. Postprocedure evaluation revealed sustained tremor reduction with minimal side effects, showcasing bilateral MRgFUS as an effective, noninvasive option for essential tremor management.
The video can be found here: https://stream.cadmore.media/r10.3171/2024.7.FOCVID2483
ПАТРІОТИЧНЕ ВИХОВАННЯ УЧНІВ СТАРШИХ КЛАСІВ: ШЛЯХИ І ПЕРСПЕКТИВИ
Authors: Цибулько Людмила , Білецький Олексій , Роганов Максим 
Published: October 2024

У статі проаналізовано основні проблеми формування почуття патріотизму сучасних школярів старших класів. Базуючись на аналізі державних документів в сфері загальної освіти останніх років («Стратегія національно-патріотичного виховання дітей та молоді на 2016 — 2020 роки» (2015 р.), «Стратегія національно-патріотичного виховання» (2019 р.), «Концепція національно-патріотичного виховання дітей і молоді» (2015 р.) тощо), було визначено основні завдання (освітні, виховні, розвивальні) щодо розвитку системи патріотичного виховання і побудови міцного підґрунтя для формування громадянської позиції школярів.
У статті також підкреслено виховну роль сімейних цінностей та місцевого матеріалу (історія рідного краю, традиції родини та місцевості). З огляду на важливість такого матеріалу, авторами пропонується наповнення відповідним навчальним і виховним змістом такої навчальної дисципліни, як «краєзнавство».
Акцентується увага на виховному значенні для формування чіткої громадянської позиції на приклади подій і вчинків людей, що відбуваються в рамках боротьби Української Держави з російською агресією.
ПРОЄКТУВАННЯ ФОРМ ПЕДАГОГІЧНОЇ ПІДГОТОВКИ МАЙБУТНІХ ХОРЕОГРАФІВ В УМОВАХ МАГІСТРАТУРИ
Authors: Лебедик Леся 
Published: October 2024

У статті наголошується актуальність проблеми підвищення якості педагогічної і психологічної підготовки майбутніх хореографів в сучасних умовах воєнної агресії. Авторка підкреслює зростання потреби соціуму у максимальному використанні усіх резервів, зокрема, реформування наявних форм психолого-педагогічної підготовки хореографів у закладах вищої освіти.
Проблематика проєктування форм педагогічної підготовки майбутніх хореографів в умовах магістратури аналізується через призму самоорганізаційного і модульного підходів.
Очікуваними результатами проєктування форм педагогічної підготовки майбутніх хореографів з дисципліни «Педагогіка і психологія вищої школи» є: знання функцій, предмету, основних категорій педагогіки і психології вищої школи, основних дидактичних концепцій; розуміння психологічних особливостей діяльності викладача хореографії, структури, характеристики та основних напрямів роботи викладача хореографії; уміння визначати сутність та специфіку навчально-виховної діяльності у закладі освіти та основні напрями діяльності викладача хореографії; володіння загальними та спеціальними засобами, технологіями, методами та прийомами підготовки і проведення лекційних та семінарських занять; уміння реалізовувати різноманітні форми проведення практичних занять та організації самостійної роботи здобувачів освіти з хореографії; знання психологічної характеристики студентства як особливого науково-освітнього середовища; уміння демонструвати практичні уміння і навички, визначати виховні цілі, пов’язані з розвитком професійно важливих якостей особистості студентів; уміння моделювати професійні ситуації; уміння проєктувати і реалізувати професійну самоосвіту з проблем викладання хореографії та дослідно-пошукової діяльності.
Розглядаються вимоги до проєктування таких видів лекцій, як вступна лекція, проблемна лекція, лекція-диспут, лекція із запланованими помилками, а також практичних і залікових занять, самостійної роботи, ділових ігор, конференцій, консультування тощо.
The Role of Omentin-1 and Fibroblast Growth Factor-23 in Iraqi Patients with Prostate Cancer during Chemotherapy
Authors: Al-qazzaz Ammar , Altaie Anwar F. 
Published: October 2024

Background: Omentin-1 is mainly expressed in stromal vascular cells of adipose tissue and can also be expressed in airway goblet cells, mesothelial cells, and vascular cells. Fibroblast growth factor 23 (FGF-23), generated by bone cells, regulates phosphate and vitamin D metabolism by regulating phosphate reabsorption in the kidneys and inhibiting vitamin D activation. Vitamin D is a fat-soluble vitamin that regulates calcium absorption, bone health, and immunological function. Prostate cancer is a significant health concern for men worldwide. Several studies demonstrated a link between these variables and cancer as they exert important anti-inflammatory, antioxidative, and anti-cancer functions.
Objectives: To assess the impact of Omentin and FGF-23 biochemical functions, as well as the anti-cancer properties of vitamin D.
Subjects and methods: This is a case-control study on serum samples collected from Iraqi prostate cancer patients after receiving chemotherapy at Al Amal Center in Imam Hussein Medical City in Karbala between November 2022 to May 2023. The serum samples were collected from two groups: control group consisted of 30 healthy males. Patient group consisted of 30 prostate cancer patients after receiving chemotherapy, both groups aged 45 – 80 years. The two groups were matched for body mass index. ELISA technology was used to estimate serum levels of the aforementioned biochemical parameters with vitamin D.
Results: patient group had a significantly higher FGF-23 level than control group (309.5±41.65) versus (163.1±22.4) (p<0.001). On the other hand, Irisin, Omentin and Vitamin D mean serum concentrations were significantly lower in-patient group (15.2±4.24), (13.8±4.28) and (4.4±0.69) (p<0.001), respectively, compared to control group (60.8±3.5), (38.8±6.59), and (18.9±2.36), respectively. (ROC) curve analysis identified the best AUC values of FGF-23, Omentin, and Vitamin D (0.995, 0.959, 0.937), respectively, which suggests a high level of accuracy.
Conclusions: These parameters may serve as critical indicators for prostate cancer patients and their disease progress. Vitamin D insufficiency is a risk factor for these individuals.
عزل وتوصيف المركبات الفينولية في أوراق الجوافة وتقييم النشاط السام للخلايا ضد خلايا سرطان الثدي العراقي
Authors: Enas J.  , Kareem Ashwaq T. 
Published: October 2024

لخلفية:الجوافة، هو نبات استوائي غني بالعديد من المكونات الكيميائية النباتية وله العديد من الاستطبابات التقليدية التي حددتها الدراسات السابقة. ينتمي نبات الجوافة إلى الفصيلة الآسية، أفادت العديد من الدراسات السابقة عن نشاط دوائي خاص ضد العديد من خطوط الخلايا السرطانية. الأهداف : تركز هذه الدراسة على عزل المركبات الفينولية من أوراق الجوافة المزروعة حديثاً في العراق وتقييم النشاط السام للخلايا لمستخلص الجوافة ضد خلايا السرطانيه لخلايا سرطان الثدي العراقي وخلايا سرطان الثدي .الطريقة:عملية التحليل تضمنت استخدام كروماتوكرافيا السائل عالي الأداء وعزل المركبات الفينولية بواسطة كروماتوكرافيا السائل عالي الأداء الكمي.النتائج: وقد أثبتت تقنيات العزل فعاليتها في الحصول على عينات نقية من حامض الكافييك واللتيولين و الكامبيفيرول من أسيتات الإيثيل وأجزاء البيوتانول ، تم تقييم النشاط السام للخلايا لمستخلص الجوافة ، الغني بالفلافونويدات المعزولة، ضد خط خلايا سرطان الثدي العراقي وسرطان الثدي وأظهر جزء أسيتات الإيثيل تأثيرًا سامًا للخلايا بانخفاض في بقاء الخلية (٪) مع تركيز موافق للتثبيط النصفي ٤١٤.٣ ميكروغرام / مل ضد خلايا سرطان الثدي العراقي وانخفاض في بقاء الخلية (٪) مع تركيز موافق للتثبيط النصفي ٦٩٨.٣ ميكروغرام / مل ضد خلايا سرطان الثدي. الاستنتاج: قدمت هذه الأساليب التحليلية فهمًا شاملاً للمركبات الفينولية الموجودة في أوراق الجوافة وايظا وضحت امتلاك الجوافة نشاطًا سامًا للخلايا ضد بعض أنواع خلايا السرطان، اعتمادًا على الترك
Cognitive Reserve Relationship with Physical Performance in Dementia-Free Older Adults: The MIND-China Study
Authors: Dong Qiwei , Li Yuanjing , Song Yiming , Zhang Yu , Han Xiaodong , Ren Yifei , Wang Jiafeng , Han Xiaojuan , Du Yifeng 
Published: October 2024

Background: Cognitive reserve (CR) may be beneficial to the physical function of the elderly. Objective: We aimed to examine the association of CR proxies and composite CR capacity with physical function in older adults while considering age and sex. Methods: This population-based cross-sectional study included 4,714 participants living in rural China (age≥60 years) who were dementia-free. Structural equation modeling was used to generate a composite CR score by integrating early-life education, midlife occupational complexity, and late-life mental activity and social support. The Short Physical Performance Battery (SPPB) measured physical function. Data were analyzed using linear regression models. Results: Greater educational attainment and mental activity were associated with higher composite SPPB scores and those of its three subtests ( p < 0.05). Skilled occupations were associated with higher SPPB, chair stand, and walking speed scores, while greater social support was associated with higher scores for SPPB and chair stand ( p < 0.05). Each 1-point increase in composite CR score (range: –0.77 to 1.03) was linearly associated with a multivariable-adjusted β-coefficient of 0.74 (95% confidence interval (CI): 0.58–0.89) for total SPPB score, 0.16 (0.10–0.22) for balance test, 0.40 (0.32–0.48) for chair stand, and 0.17 (0.12–0.23) for walking speed. The association between higher composite CR and total SPPB scores was more prominent in those≥75 years than those aged 60–74 years ( p < 0.01). There was no statistical interaction of composite CR score and sex in physical function. Conclusions: High CR is associated with better physical function, especially among older adults (≥75 years).
In silico testing to identify compounds that inhibit ClfA and ClfB binding to the host for the formulation of future drugs against Staphylococcus aureus colonization and infection
Authors: Singh Shila Kumari , Bhattacharjee Minakshi , Unni Balagopalan , Kashyap Rajpal Singh , Malik Abdul , Akhtar Suhail , Fatima Sabiha 
Published: October 2024

IntroductionStaphylococcus aureus is a highly resistant pathogen. It has multiple virulence factors, which makes it one of the most pathogenic bacteria for humankind. The vast increase in antibiotic resistance in these bacteria is a warning of existing healthcare policies. Most of the available antibiotics are ineffective due to resistance; this situation requires the development of drugs that target specific proteins and are not susceptible to resistance.MethodsIn this study, we identified a compound that acts as an antagonist of ClfA and ClfB by inhibiting their binding to host cells.ResultsThe shortlisted compound’s binding activity was tested by docking and molecular dynamics during its interaction with proteins. The identified compound has excellent binding energy with both ClfA (-10.11 kcal/mol) and ClfB (-11.11 kcal/mol).DiscussionThe molecular dynamics of the protein and compound were stable and promising for further in vitro and in vivo tests. The performance of our compound was tested and compared with that of the control molecule allantodapsone, which was reported in a previous study as a pan inhibitor of the clumping factor. An ADMET study of our selected compound revealed its reliable drug likeliness. This compound is an ideal candidate for in vitro studies.
Climate change stands as the new challenge for whale watching and North Pacific gray whales (Eschrichtius robustus) in Bahia Magdalena, Mexico, after their recovery from overexploitation
Authors: García-Castañeda Omar , Viloria-Gómora Lorena , Ávila-Foucat Véronique Sophie , Vega-Peña Ernesto Vicente , Pardo Mario A. , Quintero-Venegas Gino Jafet , Urbán R. Jorge , Swartz Steven , Martínez-Meyer Enrique 
Published: October 2024

IntroductionSocial-ecological systems (SES) recognize the intricate relationship between human activities and the environment and advocate for comprehensive approaches to address complex environmental issues. This study investigates the factors influencing whale watching, particularly the gray whale (Eschrichtius robustus) in northern Mexico, after significant recovery following overexploitation. Despite reaching a peak in 2015, the eastern North Pacific gray whales experienced unusual mortality events (UME), the most recent from 2019 to 2023, leading to a population decline and historically low calf production in 2022. This decline is evident in the reduced presence of whales and calves in winter breeding lagoons. Concurrently, whale watching has become a significant tourist attraction in these areas.MethodsOur objective was to develop a mental model of the SES of gray whale watching, integrating ecological and socioeconomic data to identify key variables and interactions that support system resilience. From an ecological perspective, we analyzed the long-term temporal trends of eight years of gray whale counts in the southernmost breeding and nursing lagoons within the Bahía Magdalena–Bahía Almejas Complex, Mexico. Additionally, we incorporated the current discussion in the literature about the potential impact of global climate change on gray whale populations. In the socioeconomic subsystem, we used participatory methods, including interviews, surveys, and workshops with government officials, tourism operators, and visitors. We also added on-site assessments of compliance with welfare regulations to understand tourism dynamics. ResultsOur findings identified as main external stressors the changes in ice levels in feeding areas and sea warming in breeding areas, and as internal stressors the compliance with official regulations and the number of vessels observing whales at the same time. The key socioeconomic factor of the system was tourist satisfaction, influenced by factors such as the quality of the information provided by operators. DiscussionUltimately, our mental model provides a framework for further exploration of relevant interactions and trajectories, offering insights for developing effective management strategies.
Influences of inflow rates on the breach characteristics of landslide dams
Authors: Jiang Xiangang , Zhang Zongliang , Deng Hongyan 
Published: October 2024

IntroductionDams formed by landslides may produce disastrous floods after dam outbursts. However, understanding of the influence of the inflow rate on the breaching characteristics of landslide dams is still at an early stage; in particular, the relationship between breaching width and depth are still unclear.MethodsIn this paper, we present the results of a series of laboratory tests that assessed seven inflow rates (1, 1.5, 2, 2.5, 3, 3.5, and 4 L/s).Results and discussionThe results show that breaching characteristics for different inflow rates are similar and that there are three breach stages for different inflow rates. The peak discharge gradually increases as the inflow rate increases. With increasing inflow rate, the breach depth and width both increase. The ratio of breach width to breach depth increases from less than 1 to 1 progressively with increasing inflow rate. The breaching width and depth can be expressed by the function W=ζ1+e−kD−D0. The shape parameter k has an exponential relationship with the inflow rate.
Dissecting the importance and origin of circulating myokines in gastric cancer cachexia
Authors: Sierzega Marek , Drabik Anna , Sanak Marek , Chrzan Robert , Richter Piotr 
Published: October 2024

BackgroundSome experimental data suggest that myokines may play an important role in developing cancer-associated cachexia (CAC), but their relevance in humans remains poorly explored. In our study, we tested the hypothesis that circulating myokines are associated with the pathogenesis of CAC in a model population of gastric cancer.MethodsA group of 171 treatment naïve patients with adenocarcinoma of the stomach were prospectively examined. Cachexia was defined as weight loss &gt;5% or weight loss &gt;2% with either BMI &lt;20 kg/m2 or sarcopenia. A panel of 19 myokines was measured in portal and peripheral blood as well as tumour tissue and surrounding gastric mucosa. Moreover, a serum proteomic signature of cachexia was identified by a label-free quantitative proteomics with a nano LC-MS/MS system and stored in a ProteomeXchange database (PXD049334).ResultsOne hundred (58%) patients were diagnosed with CAC. The concentrations of fatty acid-binding protein 3 (FABP3), follistatin-like 1 protein (FSTL−1), interleukin 6 (IL 6), and interleukin 8 (IL 8) were significantly higher in the peripheral blood of cachectic subjects, while leptin levels were lower. Of all the evaluated myokines, tumour tissues showed higher expression levels only for IL-15 and myostatin. However, the analysis of paired samples failed to demonstrate a decreasing concentration gradient between the portal and peripheral blood for any of the myokines, evidencing against their release by the primary tumour. Proteomic analysis identified 28 proteins upregulated and 24 downregulated in the peripheral blood of patients with cachexia. Differentially expressed proteins and 5 myokines with increased serum levels generated a significant protein-protein interaction network.ConclusionsOur study provides clinical evidence that some myokines are involved in the pathogenesis of cachexia and are well integrated into the regulatory network of circulating blood proteins identified among cachectic patients with gastric cancer.
MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women
Authors: Yalaev Bulat , Deev Roman , Tyurin Anton , Salakhov Ramil , Smirnov Kirill , Eremkina Anna , Mokrysheva Natalia , Minniakhmetov Ildar , Khusainova Rita 
Published: October 2024

IntroductionThe identification of significant DNA markers of primary osteoporosis may gain new insights by studying genome regions involved in mechanisms of epigenetic regulation through interactions with microRNAs.MethodsThe authors searched for associations of polymorphic variants of microRNA binding sites of mRNA target genes and polymorphic loci of microRNA genes with primary osteoporosis in a cohort of women and men from the Volga-Ural region of Russia (N = 1.177).ResultsUsing case-control association analysis, the authors found that rs1061947 (COL1A1), rs10793442 (ZNF239), rs6854081 (FGF2), and rs11614913 (miR-196a) were associated with osteoporotic fractures; rs5854 (MMP1) and rs2910164 (miR-146a) were associated with low bone mineral density; and rs10098470 (TPD52), rs11540149 (VDR), rs1042673 (SOX9), rs1054204 (SPARC), and rs1712 (FBXO5) were markers of both fractures and low bone mineral density. Among the identified associations, ethno specific trends were found, as well as sex-specific associations. Prognostic models were developed, among which the model for predicting osteoporosis in general in women (Area Under Curve = 0.909) achieved the highest level of predictive value. Thus, the potential role of polymorphic variants of microRNA binding sites in the development of primary osteoporosis in men and women from the Volga-Ural region of Russia was demonstrated.
Simultaneous use of convection and radiation heat transfer for Iranian pistachio drying using catalytic heater - numerical and experimental study
Authors: Ebrahimpour Vahid , Esmailpour Kazem 
Published: October 2024

This study presents a comprehensive investigation into the simultaneous use of convection and radiation heat transfer for Iranian pistachio drying using a catalytic heater. Both experimental and numerical analyses were conducted to evaluate the performance of the proposed system. The experimental setup involved a catalytic infrared heater, which provided a consistent temperature of approximately 370 K within the drying chamber. The results indicated that the drying time was reduced by 40% compared to traditional hot air drying methods, with an average moisture reduction rate of 0.8% per minute. The numerical analysis, conducted using computational fluid dynamics (CFD) simulations, supported the experimental findings, showing a uniform temperature distribution across the pistachios and efficient heat transfer. The catalytic heater demonstrated a combustion efficiency of 98%, with CO emissions below 10 ppm and zero NOx emissions, highlighting its environmental benefits. Overall, the combined experimental and numerical results confirmed that the proposed catalytic heater system not only enhances drying efficiency but also significantly reduces energy consumption and greenhouse gas emissions compared to conventional drying methods.