bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten month outcome of cognitive behavioural therapy v. interpersonal psychotherapy in patients with major depression: a randomised trial of acute and maintenance psychotherapy
Authors: Mulder R. , Boden J. , Carter J. , Luty S. , Joyce P. 
Published: May 2017

BackgroundCognitive behaviour therapy (CBT) and interpersonal psychotherapy (IPT) are the most studied psychotherapies for treatment of depression, but they are rarely directly compared particularly over the longer term. This study compares the outcomes of patients treated with CBT and IPT over 10 months and tests whether there are differential or general predictors of outcome.MethodsA single centre randomised controlled trial (RCT) of depressed outpatients treated with weekly CBT or IPT sessions for 16 weeks and then 24 weeks of maintenance CBT or IPT. The principle outcome was depression severity measured using the MADRS. Pre-specified predictors of response were in four domains: demographic depression, characteristics, comorbidity and personality. Data were analysed over 16 weeks and 40 weeks using general linear mixed effects regression models.ResultsCBT was significantly more effective than IPT in reducing depressive symptoms over the 10 month study largely because it appeared to work more quickly. There were no differential predictors of response to CBT v. IPT at 16 weeks or 40 weeks. Personality variables were most strongly associated with overall outcome at both 16 weeks and 40 weeks. The number of personality disorder symptoms and lower self-directness and reward dependence scores were associated with poorer outcome for both CBT and IPT at 40 weeks.ConclusionsCBT and IPT are effective treatments for major depression over the longer term. CBT may work more quickly. Personality variables are the most relevant predictors of outcome.
Prominence of gender cues in the assignment of thematic roles in German
Authors: ESAULOVA YULIA , REALI CHIARA , VON STOCKHAUSEN LISA 
Published: May 2017

ABSTRACTTwo eye-tracking experiments examined influences of grammatical and stereotypical gender cues on the assignment of thematic roles in German. Participants (N1= 32,N2= 40) read sentences with subject- and object-extracted relative clauses, where thematic agents and patients remained ambiguous until the end of the relative clause. The results reveal a linguistic gender bias: agent roles are assigned more easily to grammatically masculine than feminine role nouns and stereotypically neutral than female ones. The opposite pattern is observed in the assignment of patient roles for stereotypical but not grammatical gender. The findings are discussed within the framework of situation model theories as well as in constraint-based and similarity-based interference accounts, while gender is viewed as a dimension of prominence.
Social support and care arrangements of older people living alone in rural Malaysia
Authors: EVANS NATALIE , ALLOTEY PASCALE , IMELDA JOANNA D. , REIDPATH DANIEL D. , POOL ROBERT 
Published: May 2017

ABSTRACTMalaysia has an ageing population and an increasing number of older people who live alone. This study explores the social support and care arrangements of older people living alone in rural Malaysia. The study took a qualitative approach: semi-structured interviews were conducted with a purposive sample of Malay (N = 20) and Chinese (N = 20) Malaysians aged over 65. Five cross-cutting themes were identified through a thematic analysis: degrees of aloneness; relationships and social support; barriers to social support; and future illness, care and death. All participants said they lived alone; living arrangements, however, were often complex. For Malays, most support came from nearby adult children and relatives, whereas Chinese participants, who less frequently had adult children living locally, emphasised support from friends and neighbours. Emigrant adult children's assistance was mostly informational and financial, instrumental assistance was either substituted for money, or provided solely during periods of ill-health. Physical decline, limited telephone use, inadequate transportation and fears of crime were barriers to social support. Participants avoided thinking or talking about future care needs. These findings have implications for Malaysian old age policy, which is currently focused on supporting families to care for older relatives. Child migration and a growing preference for a period of independent living in old age may require policies and resources directed at older people as individuals to support their own efforts to remain independent, active and age ‘in place’.
Planning Agricultural Exports in a Developing Country: The Indian Case
Authors: Mukherjee Tridib K. , Moore John R. 
Published: May 2017

ObjectiveThis paper reports findings of a study of how India has planned her agricultural exports, the problems she has encountered, and the lessons she has learned in the process of value to other developing countries. The problems and lessons are discussed in detail after a general overview of India's planning system and trade situation.IntroductionIndia gained independence in 1947 and has since followed a socialistic economic policy. Such a policy has proven rather difficult, however, due to a lack of government finances and ownership of most means of production. To help make and implement her economic policies, the Indian government has established a planning commission. It is responsible for drawing up the country's five-year plans and seeing they are implemented by the government's various executive ministries. India is currently in her fourth five-year plan (1969–1974).
WHAT’S IN THE TEXTBOOK AND WHAT’S IN THE MIND
Authors: Marsden Heather , Whong Melinda , Gil Kook-Hee 
Published: May 2017

AbstractThis paper presents an experimental study of the rarely explored question of how input through instruction interacts with L2 acquisition at the level of modular linguistic knowledge. The investigation focuses on L2 knowledge of the English polarity itemany, whose properties are only partially covered by typical language-teaching materials. We investigate Najdi-Saudi Arabic-speaking learners’ knowledge of the distribution ofanyin contexts that are taught, contexts that are not taught but may be observable in the input, and contexts that are neither taught nor observable. We further test whether conscious awareness of instructed rules aboutanycorrelates with performance. Our findings suggest a role for instruction and for internal, UG-constrained acquisition, and that these two paths interact. We explore our findings in terms of Sharwood Smith and Truscott’s (2014a, 2014b) framework of modular online growth and use of language, in which cognitive development is driven by processing.
Regular monitoring of breast-feeding rates: feasible and sustainable. The Emilia-Romagna experience
Authors: Di Mario Simona , Borsari Silvana , Verdini Eleonora , Battaglia Sergio , Cisbani Luca , Sforza Stefano , Cuoghi Chiara , Basevi Vittorio 
Published: May 2017

AbstractObjectiveAn efficient breast-feeding monitoring system should be in place in every country to assist policy makers and health professionals plan activities to reach optimal breast-feeding rates.Design/Setting/SubjectsFrom March to June 2015, breast-feeding rates at 3 and 5 months of age were monitored in Emilia-Romagna, an Italian region, using four questions added to a newly developed paediatric immunization database with single records for each individual. Data were collected at primary-care centres. Breast-feeding definitions and 24 h recall as recommended by the WHO were used. Direct age standardization was applied to breast-feeding rates. Record linkage with the medical birth database was attempted to identify maternal, pregnancy and delivery factors associated with full breast-feeding rates at 3 and 5 months of age.ResultsData on breast-feeding were collected for 14044 infants. The mean regional full breast-feeding rate at 3 months was 52 %; differences between local health authorities ranged from 42 to 62 %. At 5 months of age, the mean regional full breast-feeding rate dropped to 33 % (range between local health authorities: 26 to 46 %). Record linkage with the birth certificate database was successful for 93 % of records. Total observations more than doubled with respect to the previous regional survey.ConclusionsThe new monitoring system implemented in 2015 in Emilia-Romagna region, totally integrated with the immunization database, has proved to be feasible, sustainable and more efficient than the previous one. This system can be a model for other regions and countries where the vast majority of mothers obtain vaccinations from public health facilities and that already have an immunization database in place.
Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review
Authors: Gadde U. , Kim W. H. , Oh S. T. , Lillehoj Hyun S. 
Published: May 2017

AbstractWith the increase in regulations regarding the use of antibiotic growth promoters and the rise in consumer demand for poultry products from ‘Raised Without Antibiotics’ or ‘No Antibiotics Ever’ flocks, the quest for alternative products or approaches has intensified in recent years. A great deal of research has focused on the development of antibiotic alternatives to maintain or improve poultry health and performance. This review describes the potential for the various alternatives available to increase animal productivity and help poultry perform to their genetic potential under existing commercial conditions. The classes of alternatives described include probiotics, prebiotics, synbiotics, organic acids, enzymes, phytogenics, antimicrobial peptides, hyperimmune egg antibodies, bacteriophages, clay, and metals. A brief description of the mechanism of action, efficacy, and advantages and disadvantages of their uses are also presented. Though the beneficial effects of many of the alternatives developed have been well demonstrated, the general consensus is that these products lack consistency and the results vary greatly from farm to farm. Furthermore, their mode of action needs to be better defined. Optimal combinations of various alternatives coupled with good management and husbandry practices will be the key to maximize performance and maintain animal productivity, while we move forward with the ultimate goal of reducing antibiotic use in the animal industry.
Two Islamic Movements in conflict in terms of linguistic nationalism
Authors:   ANONYMOUS
Published: May 2017

AbstractReligion and nationalism are not only two distinctive but also closely related concepts when it comes to nation-building. Their role in language policy and linguistic nationalism is pervasive. Today, in Turkey, two religious movements of the same origin play a key role in linguistic nationalism and decision-making in language policy: the Gülen movement and the Med-Zehra movement. These two non-governmental affinities are important groups in the Nur movement. The Gülen movement is supportive of Turkish nationalism and thereby Turkish language and identity, while the Med-Zehra group emphasizes Kurdish identity and separatism. This study makes a comparison between the two movements and investigates in detail their role in language policy and linguistic nationalism.
The Planetary Nebula Luminosity Function and its Issues
Authors: Ciardullo Robin 
Published: May 2017

AbstractThe bright-end cutoff of the [O III] λ5007 planetary nebula luminosity function (PNLF) is insensitive to population age and metallicity, making it an excellent extragalactic standard candle. We review our knowledge of the function and discuss the challenges related to modeling it. We show that, while there has been a great deal of progress in understanding the nuances of its shape, there is still no solid theory which explains the luminosity of the PNLF cutoff in old stellar populations. This is an extremely serious problem, as it affects a myriad of astrophysical issues, from the determination of the stellar masses of galaxies to our understanding of alternative channels of stellar evolution.
Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice
Authors: Beier Eric E , Sheu Tzong-Jen , Resseguie Emily A , Takahata Masahiko , Awad Hani A , Cory-Slechta Deborah A , Puzas J Edward 
Published: May 2017

AbstractStress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress (PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead (Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure (100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously (controlled-release pellet, 5 mg·kg−1 per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization. Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone.
Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma
Authors: Li Zhigang , Fan Erica K , Liu Jinghua , Scott Melanie J , Li Yuehua , Li Song , Xie Wen , Billiar Timothy R , Wilson Mark A , Jiang Yong , Wang Ping , Fan Jie 
Published: May 2017

AbstractTrauma is a major cause of systemic inflammatory response syndrome and multiple organ dysfunction syndrome. Macrophages (Mφ) direct trauma-induced inflammation, and Mφ death critically influences the progression of the inflammatory response. In the current study, we explored an important role of trauma in inducing mitochondrial DNA (mtDNA) damage in Mφ and the subsequent regulation of Mφ death. Using an animal pseudo-fracture trauma model, we demonstrated that tissue damage induced NADPH oxidase activation and increased the release of reactive oxygen species via cold-inducible RNA-binding protein (CIRP)–TLR4–MyD88 signaling. This in turn, activates endonuclease G, which serves as an executor for the fragmentation of mtDNA in Mφ. We further showed that fragmented mtDNA triggered both p62-related autophagy and necroptosis in Mφ. However, autophagy activation also suppressed Mφ necroptosis and pro-inflammatory responses. This study demonstrates a previously unidentified intracellular regulation of Mφ homeostasis in response to trauma.
The novel long intergenic noncoding RNA UCC promotes colorectal cancer progression by sponging miR-143
Authors: Huang Feng-Ting , Chen Wen-Ying , Gu Zhi-Qiang , Zhuang Yan-Yan , Li Chu-Qiang , Wang Ling-Yun , Peng Juan-Fei , Zhu Zhe , Luo Xin , Li Yuan-Hua , Yao He-Rui , Zhang Shi-Neng 
Published: May 2017

AbstractThe human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. A novel lincRNA termed upregulated in CRC (UCC) was found to be highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node metastasis, Dukes’ stage, and patient outcomes. In SW480 and SW620 cells, knockdown of UCC inhibited proliferation, invasion, and cell cycle progression and induced apoptosis in vitro. Xenograft tumors grown from UCC-silenced SW620 cells had smaller mean volumes and formed more slowly than xenograft tumors grown from control cells. Inversely, overexpression of UCC in HCT116 promoted cell growth and invasion in vitro. Bioinformatics analysis, dual-luciferase reporter assays, and RNA immunoprecipitation assays showed that miR-143 can interact with UCC, and we found that UCC expression inversely correlates with miR-143 expression in CRC specimens. Moreover, mechanistic investigations showed that UCC may act as an endogenous sponge by competing for miR-143, thereby regulating the targets of this miRNA. Our results suggest that UCC and miR-143 may be promising molecular targets for CRC therapy.
All-trans retinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells
Authors: Liu XiangZhen , Chen Juan , Yu ShanHe , Yan Li , Guo HeZhou , Dai JianMin , Zhang Wu , Zhu Jiang 
Published: May 2017

AbstractAll-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO) administration leads to granulocytic maturation and/or apoptosis of acute promyelocytic leukemia (APL) cells mainly by targeting promyelocytic leukemia/retinoic acid receptor alpha (PML/RARα). Yet, ~10–15% of APL patients are not cured by ATRA- and ATO-based therapies, and a potential failure of ATRA and ATO in completely reversing PML/RARα-driven oncogenic alterations has not been comprehensively examined. Here we characterized the in vivo primary responses of dysregulated genes in APL cells treated with ATRA and ATO using a GFP-labeled APL model. Although induced granulocytic differentiation of APL cells was evident after ATRA or ATO administration, the expression of the majority of dysregulated genes in the c-Kit+ APL progenitors was not consistently corrected. Irf8, whose expression increased along with spontaneous differentiation of the APL progenitors in vivo, represented such a PML/RARα-dysregulated gene that was refractory to ATRA/ATO signaling. Interestingly, Irf8 induction, but not its knockdown, decreased APL leukemogenic potential through driving monocytic maturation. Thus, we reveal that certain PML/RARα-dysregulated genes that are refractory to ATRA/ATO signaling are potentially crucial regulators of the immature status and leukemogenic potential of APL cells, which can be exploited for the development of new therapeutic strategies for ATRA/ATO-resistant APL cases.
A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis
Authors: Okada Morihiro , Miller Thomas C , Wen Luan , Shi Yun-Bo 
Published: May 2017

AbstractThe Myc/Mad/Max network has long been shown to be an important factor in regulating cell proliferation, death and differentiation in diverse cell types. In general, Myc–Max heterodimers activate target gene expression to promote cell proliferation, although excess of c-Myc can also induce apoptosis. In contrast, Mad competes against Myc to form Mad–Max heterodimers that bind to the same target genes to repress their expression and promote differentiation. The role of the Myc/Mad/Max network during vertebrate development, especially, the so-called postembryonic development, a period around birth in mammals, is unclear. Using thyroid hormone (T3)-dependent Xenopus metamorphosis as a model, we show here that Mad1 is induced by T3 in the intestine during metamorphosis when larval epithelial cell death and adult epithelial stem cell development take place. More importantly, we demonstrate that Mad1 is expressed in the larval cells undergoing apoptosis, whereas c-Myc is expressed in the proliferating adult stem cells during intestinal metamorphosis, suggesting that Mad1 may have a role in cell death during development. By using transcription activator-like effector nuclease-mediated gene-editing technology, we have generated Mad1 knockout Xenopus animals. This has revealed that Mad1 is not essential for embryogenesis or metamorphosis. On the other hand, consistent with its spatiotemporal expression profile, Mad1 knockout leads to reduced larval epithelial apoptosis but surprisingly also results in increased adult stem cell proliferation. These findings not only reveal a novel role of Mad1 in regulating developmental cell death but also suggest that a balance of Mad and Myc controls cell fate determination during adult organ development.
Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer
Authors: Chen Guo-Qing , Gong Rui-Hong , Yang Da-Jian , Zhang Ge , Lu Ai-Ping , Yan Siu-Cheong , Lin Shu-Hai , Bian Zhao-Xiang 
Published: May 2017

AbstractAutophagy has a key role in metabolism and impacts on tumorigenesis. Our previous study found that halofuginone (HF) exerts anticancer activity in colorectal cancer (CRC) by downregulating Akt/mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. But whether and how HF regulates autophagy and metabolism to inhibit cancer growth remains an open question. Here, we unveil that HF activates ULK1 by downregulation of its phosphorylation site at Ser757 through Akt/mTORC1 signaling pathway, resulting in induction of autophagic flux under nutrient-rich condition. On the other hand, HF inactivates ULK1 by downregulation of its phosphorylation sites at Ser317 and Ser777 through LKB1/AMPK signaling pathway, resulting in autophagic inhibition under nutrient-poor condition. Furthermore, Atg7-dependent autophagosome formation is also induced under nutrient-rich condition or blocked in nutrient-poor environment, respectively, upon HF treatment. More interestingly, we also found that HF inhibits glycolysis under nutrient-rich condition, whereas inhibits gluconeogenesis under nutrient-poor condition in an Atg7-dependent manner, suggesting that autophagy has a pivotal role of glucose metabolism upon HF treatment. Subsequent studies showed that HF treatment retarded tumor growth in xenograft mice fed with either standard chow diet or caloric restriction through dual regulation of autophagyin vivo. Together, HF has a dual role in autophagic modulation depending on nutritional conditions for anti-CRC.
Control of type III protein secretion using a minimal genetic system
Authors: Song Miryoung , Sukovich David J. , Ciccarelli Luciano , Mayr Julia , Fernandez-Rodriguez Jesus , Mirsky Ethan A. , Tucker Alex C. , Gordon D. Benjamin , Marlovits Thomas C. , Voigt Christopher A. 
Published: May 2017

AbstractGram-negative bacteria secrete proteins using a type III secretion system (T3SS), which functions as a needle-like molecular machine. The many proteins involved in T3SS construction are tightly regulated due to its role in pathogenesis and motility. Here, starting with the 35 kb Salmonella pathogenicity island 1 (SPI-1), we eliminated internal regulation and simplified the genetics by removing or recoding genes, scrambling gene order and replacing all non-coding DNA with synthetic genetic parts. This process results in a 16 kb cluster that shares no sequence identity, regulation or organizational principles with SPI-1. Building this simplified system led to the discovery of essential roles for an internal start site (SpaO) and small RNA (InvR). Further, it can be controlled using synthetic regulatory circuits, including under SPI-1 repressing conditions. This work reveals an incredible post-transcriptional robustness in T3SS assembly and aids its control as a tool in biotechnology.