bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring the impact of relational capital on customer performance in the SME B2B sector
Authors: Agostini Lara , Nosella Anna , Soranzo Benedetta 
Published: September 2017

PurposeThe purpose of this paper is to investigate the influence that different components of relational capital (marketing capability, open innovation with business and scientific partners, technological reputation, brand) have on customer performance (CP). Moreover, the moderating effect of absorptive capacity on such relationships is tested.Design/methodology/approachFirst, the direct relationship between the different components of relational capital and CP is analyzed through a linear regression model. Then, to test the moderating effect, two distinct regression analyses are conducted into two sub-samples, defined according to the level of absorptive capacity. The authors carried out these analyses on a sample of 150 small- and medium-sized enterprises (SMEs) in the medium- and high-tech B2B context.FindingsResults of this study prove that CP is enhanced through firm marketing capability, open innovation with business partners and technological reputation, while brand and open innovation with scientific partner do not have an association with CP. In particular, the impact of marketing capability and open innovation with business actors on CP is greater for firms with higher absorptive capacity.Research limitations/implicationsThis paper, highlighting the relevance of relational capital and absorptive capacity in improving CP, enhances our knowledge about the factors that help to strengthen the relationships with customers, which is an under-investigated issue especially for SMEs competing in B2B industries, and extends our knowledge on open innovation practices.Practical implicationsFindings of this paper suggest that, to achieve better CP, managers should pay special attention to nurturing their marketing capability and high-quality relationships with external actors and invest in absorptive capacity to enhance the positive effect of such linkages.Originality/valueThis work, combining the external perspective of relational capital and the internal organizational dimension of absorptive capacity, provides valuable insights about the knowledge and resource mix that firms might rely on to achieve better customer satisfaction and loyalty.
Assessment of turbulence models for transonic oscillating airfoil
Authors: Tahani Mojtaba , Masdari Mehran , Eivazi Hamidreza , Tatar Massoud 
Published: September 2017

Purpose
This paper aims to investigate numerical solution of transonic flow around NACA0012 airfoil under sinusoidal pitch oscillation. Accordingly, effects of the amplitude and frequency of oscillations on aerodynamic coefficients are evaluated and the efficiency of the turbulent models, K-ω shear-stress transport (SST), scale adaptive simulation (SAS) and delayed detached eddy simulation (DDES), in simulation of the nonlinear phenomena – i.e. the interaction between shock and boundary layer and the shock oscillations – is studied.

Design/methodology/approach
K-ω SST, SAS and DDES models are used as turbulence approaches. The numerical results are compared with available experimental and numerical information.

Findings
According to the results inside the buffet boundaries, the DDES turbulent model expresses results that are more appropriate; however, SAS and SST models are not efficient enough in evaluating the characteristics of nonlinear flow.

Originality/value
In this research study, hybrid RANS-LES turbulence model is engaged to simulate transonic flow around pitching NACA0012 airfoil, and results are compared to the SAS and Reynolds Average Navier–Stocks simulations as well as available numerical and experimental data. In addition, effects of the amplitude and frequency of oscillations on aerodynamic coefficients are evaluated in buffet regions.
The study of potential evapotranspiration in future periods due to climate change in west of Iran
Authors: Rajabi Ahmad , Babakhani Zahra 
Published: September 2017

Purpose
This study aims to present the climate change effect on potential evapotranspiration (ETP) in future periods.

Design/methodology/approach
Daily minimum and maximum temperature, solar radiation and precipitation weather parameters have been downscaled by global circulation model (GCM) and Lars-WG outputs. Weather data have been estimated according to the Had-CM3 GCM and by A1B, A2 and B1 scenarios in three periods: 2011-2030, 2045-2046 and 2080-2099. To select the more suitable method for ETP estimation, the Hargreaves-Samani (H-S) method and the Priestly–Taylor (P-T) method have been compared with the Penman-Monteith (P-M) method. Regarding the fact that the H-S method has been in better accordance with the P-M method, ETP in future periods has been estimated by this method for different scenarios.

Findings
In all five stations, in all three scenarios and in all three periods, ETP will increase. The highest ETP increase will occur in the A1B scenario and then in the A1 scenario. The lowest increase will occur in the B1 scenario. In the 2020 decade, the highest ETP increase in three scenarios will occur in Khorramabad and then Hamedan. Kermanshah, Sanandaj and Ilam stations come at third to fifth place, respectively, with a close increase in amount. In the 2050 decade, ETP increase percentages in all scenarios are close to each other in all the five stations. In the 2080 decade, ETP increase percentages in all scenarios will be close to each other in four stations, namely, Kermanshah, Sanandaj, Khorramabad and Hamedan, and Ilam station will have a higher increase compared with the other four stations.

Originality/value
Meanwhile, the highest ETP increase will occur in hot months of the year, which are significant with regard to irrigation and water resources.
Seizing history: development and non-climate change in Small Island Developing States
Authors: Baldacchino Godfrey 
Published: September 2017

PurposeThis paper offers a critical review of climate change related initiatives in small island states, including Small Island Developing States (SIDS), which can end up as ontological traps: fuelled and supported by external donor agencies, thwarting out-migration and shifting scarce and finite resources away from other, shorter-term and locally spawned development trajectories and objectives.Design/methodology/approachThis paper is based on a selective literature review. It clusters important themes found in published research and policy documents.FindingsThe results identify a burgeoning critical voice in regards to resilience and its legitimation of climate change driven projects in SIDS. This paper recommends a more nuanced approach which also privileges migration.Originality/valueThis paper provided a critical overview and synthesis of the immobility implicit in much climate change related work, through the critical lens of island studies and post-colonial studies.
Investigating the effects of work-family spillovers, gender, and formal mentoring on career goal of managers
Authors: Kim Hyondong 
Published: September 2017

PurposeThe purpose of this paper is to identify whether work-family spillovers significantly affect company managers’ determination of career goals by examining the importance of gender and formal mentoring to these managers.Design/methodology/approachThe study sample consisted of 4,222 Korean managers compiled from a large-scale data set (Korean Women Manager Panel) that was collected by the Korea Women Development Institution in two waves (2009 and 2011).FindingsPositive work-family spillover is positively related to managers’ career goals, whereas negative work-family spillover is negatively related to such goals. In the presence of positive work-family spillover, formal mentoring is more effective in helping male managers establish and develop career goals.Research limitations/implicationsThe mentoring programs company managers are willing to engage in should be consistent with the gender role. Mentoring programs for female managers are moderately related to the importance of positive work experiences in establishing and developing their career goals. Therefore, to promote the career success of female managers, companies and societies must take actions to change the female managers’ perceptions of their management potentials.Originality/valueGender and formal mentoring programs influence the salience of company managers’ work and family roles, which determines the relationship between positive and negative work-family spillovers and career goals.
Social enterprise in the United Arab Emirates
Authors: Johnsen Sarah 
Published: September 2017

PurposeThis paper aims to summarise a contribution to the International Comparative Social Enterprise Models (ICSEM) Project from the United Arab Emirates (UAE). It particularly highlights the relevance of the social constructionist approach adopted in the study to investigate and make sense of the social enterprise concept as an imported concept in a new environment.
Design/methodology/approachThis approach is used as a thread to follow through the structure proposed by the ICSEM Project, namely, to look at the concept in context, to identify social enterprise models and establish a typology, as well as to describe institutional trajectories shaping the models. This paper highlights the constructs and institutional trajectories shaping the concept, and the main findings of the study when identifying the models and establishing the typology, based on an in-depth survey of 12 social enterprises in the UAE.
FindingsWhile this typology can be considered as a preliminary one, it reveals creative recurrent models, with the state and private sector involved as incubators. Although the UAE offers a tax-free environment, the lack of a legal and regulatory system conducive to social enterprises seems to hamper the opportunities for them to develop and scale up.
Originality/valueThis contribution is the first study to investigate the ecosystem of social enterprise and its deriving models, and to propose a preliminary typology in the UAE.
Social enterprise in New Zealand: an overview
Authors: Grant Suzanne 
Published: September 2017

PurposeThis paper aims to provide an overview of the New Zealand social enterprise (SE) landscape, identifying key influences, enablers of and barriers to SE. Initial mapping is undertaken to identify types of SE in New Zealand. The paper contributes to the wider International Comparative Social Enterprise Models mapping project.
Design/methodology/approachData collection combined reviews of previous scholarship with interviews with staff in SEs.
FindingsThe New Zealand SE landscape is still emerging. The redevelopment of Christchurch following the 2010 and 2011 earthquakes has provided many opportunities for SE growth. Government support has been limited but is at least growing in terms of recognition. In 2014, the government provided base funding for developing SE infrastructure and capacity building, which is primarily delivered through the intermediary Akina Foundation. Resourcing is a key barrier to SE growth. Four main models of SE are evident: trading not-for-profits, community economic development, business-oriented social innovation and Maori enterprises.
Research limitations/implicationsThe mapping presented is only a snap shot of current status, rather than a static model. Growth and developments in SE will see each category move as their SE activities develop.
Practical implicationsIdentifying and better understanding barriers and enablers will help further advance development of SE in New Zealand.
Originality/valueScholarship on SE in New Zealand is limited. This paper brings together key literature as well as provides an initial attempt at mapping the SE landscape. Doing so provides a starting point for further discussion and analysis.
Efficacy and safety of ticagrelor in patients with acute coronary syndrome: A meta‐analysis of randomized controlled trials
Authors: Jing Yunyan , Ni Bin , Zhou Donglai , Zhang Xingwei , Liu Shanxin 
Published: September 2017

SummaryAcute coronary syndrome (ACS) is a dangerous and urgent clinical pattern of coronary artery disease. Aspirin and adenosine diphosphate P2Y12 receptor antagonists are the standard dual anti‐platelet therapy for patients with ACS. Ticagrelor is a new oral antagonist of the adenosine diphosphate P2Y12 receptor. Randomized controlled trials (RCTs) have evaluated the efficacy and safety of ticagrelor compared to clopidogrel or prasugrel in patients with ACS, obtaining conflicting results. Thus, we conducted a meta‐analysis of these RCTs to determine the efficacy and safety of ticagrelor in patients with ACS. Results of the meta‐analysis indicate that ticagrelor decreased the risk of major adverse cardiovascular events (MACE) and all‐cause death, but increased the risk of bleeding events. In Asiatic patients, analysis indicates that ticagrelor did not decrease the risk of MACE and all‐cause death, while increasing the risk of bleeding events. Together, this meta‐analysis suggests that ticagrelor was more effective, but less safe than clopidogrel and prasugrel in patients with ACS. Subgroup analysis indicates that ticagrelor was not more effective, although less safe than clopidogrel in Asiatic patients, thus more evidence is needed to further evaluate the efficacy and safety of ticagrelor in Asiatic patients.
Antiemetic treatment in the emergency department: Patient opinions and expectations
Authors: Meek Robert , Graudins Andis , Anthony Shane 
Published: September 2017

AbstractObjectiveTo determine patient expectations of antiemetic treatment in the ED.MethodsSurvey of adult ED patients with nausea. Primary outcome: expectation of antiemetic treatment as symptoms being ‘totally gone’, ‘a lot less’, ‘a little less’ and ‘the same’. Secondary outcomes: comparison between expectations and symptom change when expectations were met; general views on indications for treatment, treatment satisfaction and reasons for additional medication use.ResultsOf 176 surveyed, treatment expectation was recorded by 165 (94%). These were: ‘totally gone’, ‘a lot less’ or ‘a little less’ for 60 (36%), 84 (51%) and 21 (13%), respectively. This pre‐treatment nomination, was matched or exceeded by the reported level of symptom reduction at 30 min, for 43/87 (49%, 95% CI: 39–60) whose expectations were met, and 6/33 (18%, 95% CI: 7–35) whose were not. The majority (117/176, 66%) believed treatment should be reserved for moderate or severe nausea; 158/176 (90%) would accept treatment if offered; 130/165 (79%) expected a treatment effect by 30 min. Treatment satisfaction findings were similar to expectations being met. Further drug treatment at 30 min was desired by 29/120 (24%) who received an antiemetic drug. Most were improved, but believed additional drugs might help more. Of the 91 not wanting more treatment, most were improved and thought no more drugs were necessary.ConclusionMost patients expected antiemetic treatment to make symptoms at least ‘a lot less’. Most also believe treatment should be reserved for moderate or severe nausea, and should take effect by 30 min.
Towards a best measure of emergency department crowding: Lessons from current Australasian practice
Authors: Jones Peter , Wells Susan , Ameratunga Shanthi 
Published: September 2017

AbstractObjectiveDespite extensive literature, how crowding in EDs should be measured is still debated. The present study aimed to describe crowding metrics used in Australasia, what they were used for, the perceived extent and frequency of crowding and the challenges faced when trying to measure crowding.MethodsA survey of ED clinical directors was undertaken between December 2014 and July 2015. Free‐text responses were categorised and thematically coded. Quantitative data were analysed descriptively and with logistic regression.ResultsThere were 113 of 145 responses (78%). Crowding was considered a major problem by 84 of 113 (74%) and not rare by 88 of 111 participants (79%). These constructs were correlated; G = −0.851, P < 0.001. Levels 1–3 EDs were less likely to report crowding as a major problem than Level 4 EDs; odds ratio 0.15 (0.03–0.69), P = 0.02. Sixteen current metrics were identified and categorised into ‘time’, ‘occupancy’ and ‘workload’ metrics. These categories of metric were used differently, and multiple metrics had more uses than single metrics. Previously described complex crowding metrics were infrequently recognised (<20%). Common challenges to measuring crowding were lack of an agreed metric (40%) and lack of buy‐in by inpatient teams or hospital management (35%).ConclusionED crowding remains a common and important problem in Australasia. Crowding is multifaceted, so a single metric might not capture all important elements of crowding or be relevant to all stakeholders. However, a metric like Access Block, which encompasses elements of time, occupancy and workload and is relevant to stakeholders outside the ED, might hold the most promise.
Alcohol and Stress Activation of Microglia and Neurons: Brain Regional Effects
Authors: Walter Thomas Jordan , Vetreno Ryan P. , Crews Fulton T. 
Published: September 2017

BackgroundCycles of alcohol and stress are hypothesized to contribute to alcohol use disorders. How this occurs is poorly understood, although both alcohol and stress activate the neuroimmune system—the immune molecules and cells that interact with the nervous system. The effects of alcohol and stress on the neuroimmune system are mediated in part by peripheral signaling molecules. Alcohol and stress both enhance immunomodulatory molecules such as corticosterone and endotoxin to impact neuroimmune cells, such as microglia, and may subsequently impact neurons. In this study, we therefore examined the effects of acute and chronic ethanol (EtOH) on the corticosterone, endotoxin, and microglial and neuronal response to acute stress.MethodsMale Wistar rats were treated intragastrically with acute EtOH and acutely stressed with restraint/water immersion. Another group of rats was treated intragastrically with chronic intermittent EtOH and acutely stressed following prolonged abstinence. Plasma corticosterone and endotoxin were measured, and immunohistochemical stains for the microglial marker CD11b and neuronal activation marker c‐Fos were performed.ResultsAcute EtOH and acute stress interacted to increase plasma endotoxin and microglial CD11b, but not plasma corticosterone or neuronal c‐Fos. Chronic EtOH caused a lasting sensitization of stress‐induced plasma endotoxin, but not plasma corticosterone. Chronic EtOH also caused a lasting sensitization of stress‐induced microglial CD11b, but not neuronal c‐Fos.ConclusionsThese results find acute EtOH combined with acute stress enhanced plasma endotoxin, as well as microglial CD11b in many brain regions. Chronic EtOH followed by acute stress also increased plasma endotoxin and microglial CD11b, suggesting a lasting sensitization to acute stress. Overall, these data suggest alcohol and stress interact to increase plasma endotoxin, resulting in enhanced microglial activation that could contribute to disease progression.
Differences in the impact of prognostic factors for hepatocellular carcinoma over time
Authors: Toyoda Hidenori , Kumada Takashi , Tada Toshifumi , Yama Tsuyoki , Mizuno Kazuyuki , Sone Yasuhiro , Maeda Atsuyuki , Kaneoka Yuji , Akita Tomoyuki , Tanaka Junko 
Published: September 2017

The aim of the present study was to evaluate the prognostic significance of serum markers that reflect tumor progression, liver function, or liver fibrosis in patients with hepatocellular carcinoma (HCC), focusing on how their impact changes over time after diagnosis. Alpha‐fetoprotein (AFP), des‐gamma‐carboxy prothrombin (DCP), albumin‐bilirubin (ALBI) score, aspartate aminotransferase to platelet ratio index (APRI), and FIB‐4 index were measured at the time of initial non‐recurrent HCC diagnosis in 1669 patients between 1997 and 2016. Survival rates after diagnosis were compared after stratifying patients by these markers. Time‐dependent receiver‐operating characteristics (ROC) analysis was carried out to assess how these markers predict patient survival or death. Serum AFP and DCP levels, ALBI score, and APRI and FIB‐4 index were strongly correlated with HCC progression, liver function, and degree of liver fibrosis, respectively. Survival rates after diagnosis were significantly different when patients were stratified by these markers. In the time‐dependent ROC analysis, AFP and DCP had a high prognostic impact within 3 years of diagnosis but the impact decreased thereafter. In contrast, APRI and FIB‐4 index had higher prognostic impact 10 years after diagnosis. ALBI score had a high prognostic impact throughout the study period. Time‐dependent ROC analysis clearly showed changes in the prognostic importance of serum markers based on the duration after diagnosis. Whereas the prognostic impact of tumor progression markers was strong in the short term, liver fibrosis markers had higher prognostic impact long after diagnosis. Liver function had constant prognostic impact on patient survival after diagnosis.
Detection of ABCB5 tumour antigen-specific CD8+ T cells in melanoma patients and implications for immunotherapy
Authors: Borchers S , Maβlo C , Müller C A , Tahedl A , Volkind J , Nowak Y , Umansky V , Esterlechner J , Frank M H , Ganss C , Kluth M A , Utikal J 
Published: September 2017

Summary
ATP binding cassette subfamily B member 5 (ABCB5) has been identified as a tumour-initiating cell marker and is expressed in various malignancies, including melanoma. Moreover, treatment with anti-ABCB5 monoclonal antibodies has been shown to inhibit tumour growth in xenotransplantation models. Therefore, ABCB5 represents a potential target for cancer immunotherapy. However, cellular immune responses against ABCB5 in humans have not been described so far. Here, we investigated whether ABCB5-reactive T cells are present in human melanoma patients and tested the applicability of ABCB5-derived peptides for experimental induction of human T cell responses. Peripheral blood mononuclear cells (PBMNC) isolated from blood samples of melanoma patients (n = 40) were stimulated with ABCB5 peptides, followed by intracellular cytokine staining (ICS) for interferon (IFN)-γ and tumour necrosis factor (TNF)-α. To evaluate immunogenicity of ABCB5 peptides in naive healthy donors, CD8 T cells were co-cultured with ABCB5 antigen-loaded autologous dendritic cells (DC). ABCB5 reactivity in expanded T cells was assessed similarly by ICS. ABCB5-reactive CD8+ T cells were detected ex vivo in 19 of 29 patients, melanoma antigen recognised by T cells (MART-1)-reactive CD8+ T cells in six of 21 patients. In this small, heterogeneous cohort, reactivity against ABCB5 was significantly higher than against MART-1. It occurred significantly more often and independently of clinical characteristics. Reactivity against ABCB5 could be induced in 14 of 16 healthy donors in vitro by repeated stimulation with peptide-loaded autologous DC. As ABCB5-reactive CD8 T cells can be found in the peripheral blood of melanoma patients and an ABCB5-specific response can be induced in vitro in naive donors, ABCB5 could be a new target for immunotherapies in melanoma.