bluuebunny/crossref_metadata_2025_split huggingface dataset:
De onomkeerbare opkomst van Public Affairs in het openbaar bestuur
Authors: Figee Ed 
Published: November 2017

The irreversible rise of Public Affairs in public administration
Reading the most recent and most revealing book of Rinus van Schendelen leads to the conclusion that lobbying is not the strongest side of the Netherlands, which is rather strange for a small country with an external orientation that goes back for centuries. As one of the (six) founding fathers of European cooperation the Netherlands could not hold this special position in the EU. The money-driven attitude of the Netherlands may be profitable short-term, but is harmful for the position of the country and for its decentralized authorities (municipalities and provinces). The Dutch political scientist Rinus van Schendelen is well known for his long years of investigation into ‘lobbying’, but what in fact can be called public affairs (PA). In his older work Van Schendelen discusses PA mainly as a managerial, instrumental, Machiavellian means for steering private and public interests. In his new book he further develops this approach by investigating processes which can contribute to the use of PA instruments for sustainable effects. The new book clearly shows that nowadays the intelligent use of social media is a necessary supplement to the intelligent use of traditional PA instruments. Because of the influence of social media an adequate training of PA professionals is urgently needed in social psychology and other relevant disciplines to prevent floor tourists and other adventurers entering the PA scene.
Relato de Experiência do PIBID: Promovendo o Ensino de Computação de forma interdisciplinar com Português no Ensino Fundamental
Authors: Torcatte Arianne , Farias Marcos , Santos Higor 
Published: November 2017

O presente artigo relata a experiência dos discentes do curso de Licenciatura em Computação e Pedagogia da Universidade de , os quais são bolsistas do PIBID, referente ao projeto de ensino de Computação de forma interdisciplinar com a disciplina de Português. Esse projeto foi realizado na escola Municipal com a turma do 7º ano B ao longo do segundo semestre de 2016. Como principais resultados, foi possível ensinar conceitos fundamentais de Computação (ex: pensamento computacional, estrutura condicional e números binários), professores foram auxiliados por softwares educativos e foi desenvolvido um objeto de aprendizagem eletrônico sobre o assunto trabalhado em sala de aula.
Reconstruction of Medial Orbital Wall Fractures without Subperiosteal Dissection: The “Push-Out” Technique
Authors: Kim Yong-Ha , Lee Jin Ho , Park Youngsoo , Kim Sung-Eun , Chung Kyu-Jin , Lee Jun-Ho , Kim Tae Gon 
Published: November 2017

Background Various surgical methods for repairing medial orbital wall fractures have been introduced. The conventional technique requires total separation of the displaced orbital bones from the orbital soft tissues. However, subperiosteal dissection around the fracture can cause additional damage. The aim of the present study is to introduce a method of reconstructing medial orbital wall fractures without subperiosteal dissection named the “push-out” technique.
Methods Six patients with post-traumatic enophthalmos resulting from an old medial orbital wall fracture and 10 patients with an acute medial orbital wall fracture were included. All were treated with the push-out technique. Postoperative computed tomography (CT) was performed to assess the correct positioning of the implants. The Hertel scale and a comparison between preoperative and postoperative orbital volume were used to assess the surgical results.
Results Restoration of the normal orbital cavity shape was confirmed by examining the postoperative CT scans. In the old fracture group, the median orbital volume of the fractured side was 29.22 cm3 preoperatively, and significantly improved postoperatively to a value of 25.13 cm3. In the acute fracture group, the median orbital volume of the fractured side was 28.73 cm3 preoperatively, and significantly improved postoperatively to a value of 24.90 cm3. Differences on the Hertel scale also improved, from 2.13 mm preoperatively to 0.25 mm postoperatively in the old fracture group and from 1.67 mm preoperatively to 0.33 mm postoperatively in the acute fracture group.
Conclusions The push-out technique can be considered a good alternative choice for old medial orbital wall fractures with posttraumatic enophthalmos, acute medial orbital wall fractures including large fractured bone segments, and single-hinged greenstick fractures.
Definition of erosion and inundation hazard zones in Todos Santos Bay, Baja California, Mexico
Authors: Montoya-Turrillas FJ , Gómez Morín-Fuentes L 
Published: November 2017

A prediction of coastline retreat was made based on relative sea level rise, considering three projected scenarios of 0.5, 1.0 and 1.5 meters, obtaining also the local component of sea level rise for Todos Santos Bay, Baja California. The “Brunn Rule” was applied with certain modifications, to calculate the coastline retreat from 1983 to 2100. Taking into account the sea level rise scenarios and the geomorphologic characteristics of the coast, the erosion and inundation hazard zones were defined, pointing out the recommendations for the development planning of the area.
Determinação, in vitro, da atividade antibacteriana da clorexidina de procedência industrial e preparada em farmácias de manipulação instaladas na Cidade do Salvador, Bahia, Brasil
Authors: Moreira Ana Cristina Azevedo , Araujo Danilo Barral de , Silva Diego Baraúna da , Campos Elisângela De Jesus , Araújo Maria Thereza Barral 
Published: November 2017

<p class="MsoNormal" style="margin-bottom: 0.0001pt; text-align: justify;"><strong><span style="font-family: ">Introdução</span></strong><span style="font-family: ">: em virtude do amplo espectro de ação, da substantividade prolongada e da estabilidade química na concentração de 0,12% e 2%, o digluconato de clorexidina é um antisséptico frequentemente prescrito como auxiliar no controle da placa dental, no tratamento das periodontopatias e até mesmo, nos tratamentos endodônticos. <strong>Objetivo</strong>: avaliar, <em>in vitro</em>, a eficácia antibacteriana do digluconato de clorexidina a 0,12 % em amostras de enxaguatórios preparados em farmácias de manipulação instaladas no comércio da Cidade do Salvador, Bahia, Brasil, comparativamente, ao produto industrializado Periogard. <strong>Metodologia: </strong>amostras de soluções de digluconato de clorexidina a 0,12 % preparadas industrialmente e através de três farmácias de manipulação instaladas em Salvador, Bahia, foram avaliadas quanto à eficácia antibacteriana frente à</span><span style="font-family: Arial, sans-serif;"> cultura de <em>Streptococcus mutans</em>, <em>Pseudomonas aeruginosa</em> e <em>Enterococcus faecalis</em></span><span style="font-family: ">. A formação dos halos de inibição de crescimento indicou o poder antibacteriano de cada enxaguatório. <strong>Resultados:</strong> os dados obtidos permitem afirmar que o efeito antibacteriano produzido pelos enxaguatórios procedentes das farmácias de manipulação “A Fórmula” e “Eco Fórmula” tiveram a mesma eficácia do produto industrializado “Periogard”, enquanto que o enxaguatório preparado pela farmácia “Flora” revelou a menor efetividade. Por fim,</span><span style="font-family: "> a cepa bacteriana de</span><em><span style="font-family: Arial, sans-serif;"> Streptococcus mutans</span></em><span style="font-family: Arial, sans-serif;"> comparada às outras duas demonstrou ser a mais sensível a este fármaco</span><span style="font-family: ">. <strong>Conclusão:</strong> </span><span style="font-family: ">de acordo com a metodologia adotada pode-se concluir que dos três enxaguatórios preparados em farmácias de manipulação, apenas um revelou eficácia antibacteriana inferior ao enxaguatório de procedência industrial. </span></p>
Snow Accumulation Variability Over the West Antarctic Ice Sheet Since 1900: A Comparison of Ice Core Records With ERA‐20C Reanalysis
Authors: Wang Yetang , Thomas Elizabeth R. , Hou Shugui , Huai Baojuan , Wu Shuangye , Sun Weijun , Qi Shanzhong , Ding Minghu , Zhang Yulun 
Published: November 2017

AbstractThis study uses a set of 37 firn core records over the West Antarctic Ice Sheet (WAIS) to test the performance of the twentieth century from the European Centre for Medium‐Range Weather Forecasts (ERA‐20C) reanalysis for snow accumulation and quantify temporal variability in snow accumulation since 1900. The firn cores are allocated to four geographical areas demarcated by drainage divides (i.e., Antarctic Peninsula (AP), western WAIS, central WAIS, and eastern WAIS) to calculate stacked records of regional snow accumulation. Our results show that the interannual variability in ERA‐20C precipitation minus evaporation (P − E) agrees well with the corresponding ice core snow accumulation composites in each of the four geographical regions, suggesting its skill for simulating snow accumulation changes before the modern satellite era (pre‐1979). Snow accumulation experiences significantly positive trends for the AP and eastern WAIS, a negative trend for the western WAIS, and no significant trend for the central WAIS from 1900 to 2010. The contrasting trends are associated with changes in the large‐scale moisture transport driven by a deepening of the low‐pressure systems and anomalies of sea ice in the Amundsen Sea Low region.
A Reappraisal of the Poya Terrane (New Caledonia): Accreted Late Cretaceous‐Paleocene Marginal Basin Upper Crust, Passive Margin Sediments, and Early Eocene E‐MORB Sill Complex
Authors: Cluzel Dominique , Whitten Matthew , Meffre Sébastien , Aitchison Jonathan C. , Maurizot Pierre 
Published: November 2017

AbstractThe Poya Terrane of New Caledonia is a composite lithotectonic unit made of (i) Campanian‐Paleocene enriched mid‐ocean ridge basalt (E‐MORB) and BABB‐type (back‐arc basin basalt) basalts and abyssal argillite (Poya Terrane basalts) and (ii) Coniacian‐Santonian sandstone, turbidites, and abyssal argillite (Kone Facies) intruded by early Eocene E‐MORB sills. Remapping reveals that the Kone Facies is more extensive than previously thought. Field data, petrography, and U‐Pb geochronology of detrital zircons show that Kone Facies sediments have the same provenance as coeval autochthonous sediments (Formation a Charbon), albeit with more abundant contemporaneous zircons. They accumulated on the eastern continental slope of the Norfolk Ridge and eventually mixed with abyssal argillite. Temporally, sill emplacement is related to subduction inception at circa 56 Ma, thus suggesting a possible genetic link. We postulate that either (i) E‐MORB intrusion was related to oblique extension and thinning of the down going plate or, alternatively, (ii) the “enriched” (off axis?) partial melt zone of the ancient ridge swept the lower plate continentward, generating E‐MORB dikes in the upper marginal basin crust, and sills in passive margin sediments before it became extinct. Thereafter, sliced marginal basin upper crust, passive margin sediments, and associated dolerite sills were obliquely accreted to the fore‐arc region, and in the NE part of the terrane, subducted and recrystallized into the blueschist facies. The Poya Terrane was eventually thrust onto the Norfolk Ridge when the latter reached the subduction zone and debris from the thrust sheet fed middle to late Eocene syntectonic basins. At the same time, mafic portions of the Poya Terrane were subducted at depth where they recrystallized into the eclogite facies, mixed with serpentinite to form the Pouebo mélange, and, finally, were exhumed in the fore‐arc region. Finally, late Oligocene faulting and hydrothermal events overprinted the NE part of the terrane in probable connection with postobduction granitoid emplacement.
Thermosensitive, Stretchable, and Piezoelectric Substrate for Generation of Myogenic Cell Sheet Fragments from Human Mesenchymal Stem Cells for Skeletal Muscle Regeneration
Authors: Yoon Jeong‐Kee , Misra Mirnmoy , Yu Seung Jung , Kim Han Young , Bhang Suk Ho , Song Seuk Young , Lee Ju‐Ro , Ryu Seungmi , Choo Yeon Woong , Jeong Gun‐Jae , Kwon Sung Pil , Im Sung Gap , Lee Tae Il , Kim Byung‐Soo 
Published: November 2017

AbstractIn a native muscle microenvironment, electrical and mechanical stimuli exist in the form of action potentials and muscle contraction. Here, a cell culture system is developed that can mimic the in vivo microenvironment and provide these stimuli to cultured cells, and it is tested whether the stimulation can promote myogenic differentiation of human umbilical cord blood mesenchymal stem cells (hUCBMSCs). A thermosensitive, stretchable, and piezoelectric substrate (TSPS) is fabricated by polydimethylsiloxane spin‐coating of aligned ZnO nanorods and subsequent poly(N‐isopropylacrylamide) grafting on the polydimethylsiloxane surface. Pulsatile mechanoelectrical cues are provided to hUCBMSCs cultured on the TSPS by subjecting the TSPS to cyclic stretching and bending, resulting in significant promotion of myogenic differentiation of hUCBMSCs as well as intracellular signaling related to the differentiation. After differentiation ex vivo, the cells are detached from the TSPS in the form of cell sheet fragments. Injection of the cell sheet fragments of differentiated cells into injured mouse skeletal muscle shows improved cell retention and muscle regeneration as compared to injection of either undifferentiated cells or differentiated dissociated cells. This system may serve as a tool for research on the electrical and mechanical regulation of stem cells and may be used to potentiate stem cell therapies.
Multifunctional AIEgens: Ready Synthesis, Tunable Emission, Mechanochromism, Mitochondrial, and Bacterial Imaging
Authors: Jiang Meijuan , Gu Xinggui , Kwok Ryan T. K. , Li Ying , Sung Herman H. Y. , Zheng Xiaoyan , Zhang Yilin , Lam Jacky W. Y. , Williams Ian D. , Huang Xuhui , Wong Kam Sing , Tang Ben Zhong 
Published: November 2017

AbstractLuminogens with aggregation‐induced emission characteristics (AIEgens) are intriguing due to its rapid expansion in various high‐tech applications. However, there is still in high demand on the development of novel AIEgens with easy preparation and functionalization, stable structures, tunable emissions, and high quantum efficiency. In this contribution, three AIEgens based on diphenyl isoquinolinium (IQ) derivatives are reported. They can be facilely synthesized and possess high structural stability, favorable visible light excitation, large Stokes shifts, high quantum yields, tunable colors, and sufficient two‐photon absorption of near‐infrared light. Importantly, they exhibit multifunctionalities. They exhibit mechanochromic property, making them capable to be applied for rewritable papers. They can also be applied in mitochondrial imaging with high specificity, cell permeability, brightness, biocompatibility, and photostability. They are promising for the applications in evaluation of mitochondrial membrane potential and image‐guided cancer cell ablation. Last, they are able to stain bacteria in a wash‐free manner. All these intriguing results suggest such readily accessible and multifunctional diphenyl IQ‐based AIEgens provide a new platform for construction of advanced materials for practical applications.
Use of Nucleoside Phosphorylases for the Preparation of Purine and Pyrimidine 2′‐Deoxynucleosides
Authors: Drenichev Mikhail S. , Alexeev Cyril S. , Kurochkin Nikolay N. , Mikhailov Sergey N. 
Published: November 2017

AbstractEnzymatic transglycosylation – the transfer of the carbohydrate moiety from one heterocyclic base to another – is being actively developed and applied for the synthesis of practically important nucleosides. This reaction is catalyzed by nucleoside phosphorylases (NPs), which are responsible for reversible phosphorolysis of nucleosides to yield the corresponding heterocyclic bases and monosaccharide 1‐phosphates. We found that 7‐methyl‐2′‐deoxyguanosine (7‐Me‐dGuo) is an efficient and novel donor of the 2‐deoxyribose moiety in the enzymatic transglycosylation for the synthesis of purine and pyrimidine 2′‐deoxyribonucleosides in excellent yields. Unlike 7‐methylguanosine, its 2′‐deoxy derivative is dramatically less stable. Fortunately, we have found that 7‐methyl‐2′‐deoxyguanosine hydroiodide may be stored for 24 h in Tris‐HCl buffer (pH 7.5) at room temperature without significant decomposition. In order to optimize the reagent ratio, a series of analytical transglycosylation reactions were conducted at ambient temperature. According to HPLC analysis of the transglycosylation reactions, the product 5‐ethyl‐2′‐deoxyuridine (5‐Et‐dUrd) was obtained in high yield (84–93%) by using a small excess (1.5 and 2.0 equiv.) of 7‐Me‐dGuo over 5‐ethyluracil (5‐Et‐Ura) and 0.5 equiv. of inorganic phosphate. Thymidine is a less effective precursor of α‐d‐2‐deoxyribofuranose 1‐phosphate (dRib‐1p) compared to 7‐Me‐dGuo. We synthesized 2′‐deoxyuridine, 5‐Et‐dUrd, 2′‐deoxyadenosine and 2′‐deoxyinosine on a semi‐preparative scale using the optimized reagent ratio (1.5:1:0.5) in high yields. Unlike other transglycosylation reactions, the synthesis of 2‐chloro‐2′‐deoxyadenosine was performed in a heterogeneous medium because of the poor solubility of the initial 2‐chloro‐6‐aminopurine. Nevertheless, this nucleoside was prepared in good yield. The developed enzymatic procedure for the preparation of 2′‐deoxynucleosides may compete with the known chemical approaches.magnified image
Chitosan/collagen blends with inorganic and organic additive—A review
Authors: Kaczmarek B. , Sionkowska A. 
Published: November 2017

AbstractThis review provides a report on recent studies of composite materials based on a chitosan and collagen mixture due to their biocompatibility and bioactivity. Those natural polymers are most widely used to obtain biomaterials. However, the materials based on chitosan/collagen complexes present poor mechanical parameters, as well as high swelling behavior and enzymatic degradation rate. Such properties are considered problematic for the material clinical application. An increased interest in composite materials has been observed due to their enhanced physicochemical properties. A composite material preparation involves different compounds addition to natural polymers. Herein, the use of organic and inorganic additives has been reported. Moreover, the potential application of composite materials based on chitosan/collagen complexes in the tissue engineering science has been discussed.
Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir
Authors: Fan Li , Zhang Silu , Zhang Chunyuan , Yin Chun , Chu Zhiqin , Song Chaojun , Lin Ge , Li Quan 
Published: November 2017

AbstractIt is discovered that sustained cytosolic drug release at a sufficient concentration is an effective mechanism to circumvent multidrug resistance and consequently enhance antitumor drug efficacy. It is showed that a simple way to enable this mechanism is to reach an intracellular kinetic balance of the drug movement between the drug released from the carrier into the cytosol and the one removed from the cell interior. By adopting nanoparticle (NP) as the drug carrier, a reservoir of drug can be maintained inside the cells upon effective cellular uptake of these NPs via endocytosis. This study shows that gradual release of the drug from the NP carrier provides a feasible scheme for sustained drug release in cells, resulting in relatively stable cytosolic drug concentration level, particularly in the drug resistant case. By implementing an “optical switch” with light irradiation on photosensitizer in the same nanoparticle carrier, cytosolic drug release is further promoted, which increases cytosolic drug concentration with good concentration retention. Enhanced drug efficacy in drug sensitive as well as resistant models is demonstrated both in vitro and in vivo. Such a mechanism is shown to efficiently circumvent multidrug resistance, and at the same time largely reduce the systemic toxicity of the anticancer drug.
A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia
Authors: DeAngelo Daniel J. , Brunner Andrew M. , Werner Lillian , Avigan David , Fathi Amir T. , Sperling Adam S. , Washington Abigail , Stroopinsky Dina , Rosenblatt Jacalyn , McMasters Malgorzata , Luptakova Katarina , Wadleigh Martha , Steensma David P. , Hobbs Gabriela S. , Attar Eyal C. , Amrein Philip C. , Ebert Benjamin L. , Stone Richard M. , Ballen Karen K. 
Published: November 2017

AbstractPatients with relapsed AML have a poor prognosis and limited responses to standard chemotherapy. Lenalidomide is an immunomodulatory drug that may modulate anti‐tumor immunity. We performed a study to evaluate the safety and tolerability of lenalidomide with mitoxantrone, etoposide and cytarabine (MEC) in relapsed/refractory AML. Adult patients with relapsed/refractory AML were eligible for this phase I dose‐escalation study. We enrolled 35 patients using a “3 + 3” design, with a 10 patient expansion cohort at the maximum tolerated dose (MTD). Lenalidomide was initially given days 1‐14 and MEC days 4‐8; due to delayed count recovery, the protocol was amended to administer lenalidomide days 1‐10. The dose of lenalidomide was then escalated starting at 5 mg/d (5‐10‐25‐50). The primary objective was tolerability and MTD determination, with secondary outcomes including overall survival (OS). The MTD of lenalidomide combined with MEC was 50 mg/d days 1‐10. Among the 35 enrolled patients, 12 achieved complete remission (CR) (34%, 90%CI 21‐50%); 30‐day mortality was 6% and 60‐day mortality 13%. The median OS for all patients was 11.5 months. Among 17 patients treated at the MTD, 7 attained CR (41%); the median OS was not reached while 12‐month OS was 61%. Following therapy with MEC and lenalidomide, patient CD4+ and CD8+ T‐cells demonstrated increased inflammatory responses to autologous tumor lysate. The combination of MEC and lenalidomide is tolerable with an RP2D of lenalidomide 50 mg/d days 1‐10, yielding encouraging response rates. Further studies are planned to explore the potential immunomodulatory effect of lenalidomide and MEC.
Elektrochemilumineszenz‐Bioassays können Fluoreszenzassays mithilfe eines wasserlöslichen Luminolderivats übertreffen
Authors: Mayer Michael , Takegami Shigehiko , Neumeier Michael , Rink Simone , Jacobi von Wangelin Axel , Schulte Silja , Vollmer Moritz , Griesbeck Axel G. , Duerkop Axel , Baeumner Antje J. 
Published: November 2017

AbstractDie effizientesten und meistgenutzten Elektrochemilumineszenz(ECL)‐Moleküle sind Luminol, [Ru(bpy)3]2+ und dessen Derivate. Luminol zeichnet sich durch sein niedriges Anregungspotential aus, jedoch sind seine Anwendungen begrenzt aufgrund der sehr geringen Wasserlöslichkeit unter physiologischen Bedingungen. Das wasserlösliche m‐Carboxyluminol wurde in einer Ausbeute von 15 % synthetisiert und erreicht neben einer hohen Löslichkeit unter physiologischen Bedingungen einen vierfachen ECL‐Signalanstieg (gegenüber Luminol). Mittels Einschluss in DNA‐modifizierte Liposome wurde ein DNA‐Assay mit einer Nachweisgrenze von 3.2 pmol L−1 ermöglicht, die 150‐fach niedriger ist als die Nachweisgrenze des entsprechenden Fluoreszenzassays. Diese bemerkenswerte Steigerung der Empfindlichkeit sowie das niedrige Anregungspotential etablieren m‐Carboxyluminol als überlegene ECL‐Sonde mit Bedeutung für Chemilumineszenz‐ und enzymatische bioanalytische Anwendungen.