bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far
Authors: Peoc’h Katell , Nuzzo Alexandre , Guedj Kevin , Paugam Catherine , Corcos Olivier 
Published: August 2017

Abstract
Acute intestinal ischemic injury (i3) is a life-threatening condition with disastrous prognosis, which is currently difficult to diagnose at the early stages of the disease; a rapid diagnosis is mandatory to avoid irreversible ischemia, extensive bowel resection, sepsis and death. The overlapping protein expression of liver and gut related to the complex physiopathology of the disease, the heterogeneity of the disease and its relative rarity could explain the lack of a useful early biochemical marker of i3. Apart from non-specific biological markers of thrombosis, hypoxia inflammation, and infection, several more specific biomarkers in relation with the gut barrier dysfunction, the villi injury and the enterocyte mass have been used in the diagnosis of acute i3. It includes particularly D-lactate, intestinal fatty acid-binding protein (FABP) and citrulline. Herein, we will discuss leading publications concerning these historical markers that point out the main limitations reagrding their use in routine clinical practice. We will also introduce the first and limited results arising from omic studies, underlying the remaining effort that needs to be done in the field of acute i3 biological diagnosis, which remains a challenge.
Use of the sFlt-1/PlGF ratio to rule out preeclampsia requiring delivery in women with suspected disease. Is the evidence reproducible?
Authors: Sabrià Enric , Lequerica-Fernández Paloma , Ganuza Paula Lafuente , Ángeles Edwin Eguia , Escudero Ana I. , Martínez-Morillo Eduardo , Alvárez Francisco V. 
Published: August 2017

Abstract

Background:
Soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) ratio has been proven to predict preeclampsia occurrence.

Methods:
Blood samples from 195 pregnant women with suspected preeclampsia were obtained at obstetric triage admission or from the high-risk pregnancy outpatient office. Serum PlGF and sFlt-1 were measured by an electrochemiluminescence immunoassay (ECLIA) on the immunoanalyser Cobas e601 (Roche Diagnostics) and the corresponding ratio was calculated. Final outcomes were reviewed by an independent obstetrician. Only the first determination was considered.

Results:
A sFlt-1/PlGF ratio of 38 or lower ruled out the need for pregnancy termination due to preeclampsia in the subsequent week with a negative predictive value (NPV) of 99.1% (sensitivity 97.1% and specificity 67.5%). None of the 76 pregnancies with first determination of an sFlt-1/PlGF ratio of 38 or lower between 24 and 34 weeks of gestation delivered due to early-onset preeclampsia. Positive likelihood ratio (PLR) of an sFlt-1/PlGF ratio above 38 for prediction of pregnancy termination due to preeclampsia within 4 weeks is analogous to published evidence.

Conclusions:
Between 24 and 34 weeks of gestation, no subsequent determination was needed to completely rule out early-onset preeclampsia when the first sFlt-1/PlGF ratio determination was 38 or lower in singleton pregnancies with signs or symptoms of this syndrome. These findings, if confirmed, will reduce costs and facilitate the implementation of the sFlt-1/PlGF ratio in women with clinical suspicion of preeclampsia in the third trimester.
Elastic recovery of polyamide 6 matrix nanocomposites and their basalt fiber co-reinforced hybrids
Authors: Mészáros László 
Published: August 2017

Abstract:The improved elastic recovery and a wider range of linear elastic behavior of multiscale hybrid polyamide 6 composites are demonstrated in this study. For the composites, basalt fiber (BF) was used as microsized, and multiwalled carbon nanotubes and surface-treated montmorillonite (MMT) as nanosized reinforcement. The materials were melt compounded, and then specimens were injection molded. To prove increased elastic behavior, a relatively simple and fast cyclic measurement method was applied, where the load was increased in each cycle and 30 s of relaxation time was allowed after unloading. The results showed that both micro- and nanoparticles can broaden the range of the elastic behavior of the polyamide 6 significantly, which is reflected in increased elastic recovery and decreased plastic deformation compliance. Nano- and microsized reinforcing materials also produce a synergistic effect, which can be explained with the physical cross-linking of the nanoparticles.
Neoadjuvant peptide receptor radionuclide therapy and modified multivisceral transplantation for an advanced small intestinal neuroendocrine neoplasm: an updated case report
Authors: Clift Ashley K. , Giele Henk , Reddy Srikanth , Macedo Rubens , Al-Nahhas Adil , Wasan Harpreet S. , Gondolesi Gabriel E. , Vianna Rodrigo M. , Friend Peter , Vaidya Anil , Frilling Andrea 
Published: August 2017

AbstractSmall intestinal neuroendocrine neoplasms (SI-NEN) frequently metastasise to regional lymph nodes, and surgery is the mainstay of therapy for such patients. However, despite the possible use of advanced surgical techniques, the resection of both primary and locoregional diseases is not always attainable. Intestinal and multivisceral transplantation has been performed in a small number of patients with conventionally nonresectable, slow-growing tumours threatening the mesenteric root but has remained controversial. The use of donor skin in “sentinel flaps” in transplantation theoretically offers advantages in tailoring immunosuppression and monitoring for rejection. We represent (with extended follow-up) the first case of a patient with inoperable extensive mesenteric metastases from SI-NEN, who underwent neoadjuvant peptide receptor radionuclide therapy before a modified multivisceral transplant with a concomitant vascularised sentinel forearm flap. At 48 months after transplantation, our patient remained at full physical activity with no evidence of disease recurrence on either tumour biochemistry or radiological imaging.
Fuzzy Approach to Decision Support System Design for Inventory Control and Management
Authors: Deb Mahuya , Kaur Prabjot , Sarma Kandarpa Kumar 
Published: August 2017

Abstract
The ubiquitous nature of inventory and its reliance on a reliable decision support system (DSS) is crucial for ensuring continuous availability of goods. The DSS needs to be designed in a manner that enables it to highlight its present status. Further, the DSS should be able to provide indications about subtle and large-scale variations that are likely to occur in the supply chain within the context of the decision-making framework and inventory management. However, while dealing with the parameters of the system, it is observed that its operations and mechanisms are surrounded by uncertain, imprecise, and vague environments. Fuzzy-based approaches are best suited for such situations; however, these require assistance from learning systems like artificial neural network (ANN) to facilitate automated decision support. When ANN and fuzzy are combined, the fuzzy neural system and the neuro-fuzzy system (NFS) are formulated. The model of the DSS reported here is based on a framework commonly known as adaptive neuro-fuzzy inference system (ANFIS), which is a version of NFS. The configured model has the advantages of both the ANN and fuzzy systems, and has been tested for the design of a DSS for use as part of inventory control. In this work, we report the design of an ANFIS-based DSS configured to work as DSS for inventory management. The system accepts demand as input and generates procurement, ordering, and holding cost to control production and supply. The system deals with a certain profitability rating required to quantify the changes in the input and is combined with the day-to-day inventory records and demand-available cycle. The effectiveness of the system has been checked in terms of number and types of membership used, accuracy generated, and computational efficiency accounted by the computation cycles required.
Investigations with Reversible Feynman Gate and Irreversible Logic Schematics
Authors: Tripathi Devendra Kr. 
Published: August 2017

Abstract
In the contemporary world there is enormous hike in communication engineering applications, outcome with massive heat dissipation from the processing nodes. So energy efficient information network is one of paramount issue nowadays. For that optical reversible computing could be a landmark with base as optical logic gate. Reduction in power dissipation, consumption could be accomplished through a blend of reversible and irreversible optical processing and the nodes may recuperate the data. Accordingly, in this article two designs with semiconductor optical amplifier, used as Mach–Zehnder interferometer based all optical reversible Feynman gate, irreversible AND logic gate within a single photonic circuit has been proposed. The output waveforms for AND logic operation, Feynman logic the P (data output identical to input), Q (A ⊕ B) has been verified at 100 Gbps data rate. The designs have been evaluated on the basis of key parameter extinction ratio factor. Numerical simulations have inferred excellent ER performance with design-2(ER>13 dB) in contrast to design-1(ER as 10.2 dB). Performance evaluations for significant deign parameters as pump current, length, width, carrier transport, confine and current injection factor yielded excellent performance. This evaluation could be an assist toward design of contemporary optical networks.
Experimental neonatal hypoxia ischemia causes long lasting changes of oxidative stress parameters in the hippocampus and the spleen
Authors: Odorcyk Felipe Kawa , Kolling Janaína , Sanches Eduardo Farias , Wyse Angela T.S. , Netto Carlos Alexandre 
Published: August 2017

Abstract
Neonatal hypoxia ischemia (HI) is the main cause of mortality and morbidity in newborns. The mechanisms involved in its progression start immediately and persist for several days. Oxidative stress and inflammation are determinant factors of the severity of the final lesion. The spleen plays a major part in the inflammatory response to HI. This study assessed the temporal progression of HI-induced alterations in oxidative stress parameters in the hippocampus, the most affected brain structure, and in the spleen. HI was induced in Wistar rat pups in post-natal day 7. Production of reactive oxygen species (ROS), and the activity of the anti oxidant enzyme superoxide dismutase and catalase were assessed 24 h, 96 h and 38 days post-HI. Interestingly, both structures showed a similar pattern, with few alterations in the production of ROS species up to 96 h often combined with an increased activity of the anti oxidant enzymes. However, 38 days after the injury, ROS were at the highest in both structures, coupled with a decrease in the activity of the enzymes. Altogether, present results suggest that HI causes long lasting alterations in the hippocampus as well as in the spleen, suggesting a possible target for delayed treatments for HI.
Estimation of Characteristic Data of Aircraft Engine Compressor based on Developed Modeling Method
Authors: Li Zeng , Yan-yan Li , Wei Long 
Published: August 2017

Abstract
To resolve the problem of low estimation accuracy of compressor characteristic parameters based on traditional Kriging model, an improved interpolation method of aircraft engine compressor characteristic parameters based on the Kriging algorithm is proposed. Considering the distribution feature of original data, a high dimensional model is built. By defining the relationship between input and output data, an unknown vector composed of characteristic parameters at a certain speed of

n
d

$${n_d}$$

can be calculated based on the Kriging model. Furthermore, a sub-model is established by the calculated data and an unknown single target at the speed of

n
d

$${n_d}$$

can be calculated. Adopt the compressor characteristic parameters of an engine to identify the feasibility of this method. Set the efficiency coefficients and flow coefficients as the unknown characteristic parameters. Simulation results illustrate that the proposed is effective and efficient.
Redox regulation of plant stem cell fate
Authors: Zeng Jian , Dong Zhicheng , Wu Haijun , Tian Zhaoxia , Zhao Zhong 
Published: August 2017

AbstractDespite the importance of stem cells in plant and animal development, the common mechanisms of stem cell maintenance in both systems have remained elusive. Recently, the importance of hydrogen peroxide (H2O2) signaling in priming stem cell differentiation has been extensively studied in animals. Here, we show that different forms of reactive oxygen species (ROS) have antagonistic roles in plant stem cell regulation, which were established by distinct spatiotemporal patterns of ROS‐metabolizing enzymes. The superoxide anion () is markedly enriched in stem cells to activate WUSCHEL and maintain stemness, whereas H2O2 is more abundant in the differentiating peripheral zone to promote stem cell differentiation. Moreover, H2O2 negatively regulates biosynthesis in stem cells, and increasing H2O2 levels or scavenging leads to the termination of stem cells. Our results provide a mechanistic framework for ROS‐mediated control of plant stem cell fate and demonstrate that the balance between and H2O2 is key to stem cell maintenance and differentiation.
Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis
Authors: Russell Jonathan R , Cabeen Matthew T , Wiggins Paul A , Paulsson Johan , Losick Richard 
Published: August 2017

AbstractEntry into sporulation in Bacillus subtilis is governed by a phosphorelay in which phosphoryl groups from a histidine kinase are successively transferred via relay proteins to the response regulator Spo0A. Spo0A~P, in turn, sets in motion events that lead to asymmetric division and activation of the cell‐specific transcription factor σF, a hallmark for entry into sporulation. Here, we have used a microfluidics‐based platform to investigate the activation of Spo0A and σF in individual cells held under constant, sporulation‐inducing conditions. The principal conclusions were that: (i) activation of σF occurs with an approximately constant probability after adaptation to conditions of nutrient limitation; (ii) activation of σF is tightly correlated with, and preceded by, Spo0A~P reaching a high threshold level; (iii) activation of Spo0A takes place abruptly just prior to asymmetric division; and (iv) the primary source of noise in the activation of Spo0A is the phosphorelay. We propose that cells exhibit a constant probability of attaining a high threshold level of Spo0A~P due to fluctuations in the flux of phosphoryl groups through the phosphorelay.
Narječno razlikovanje uz rijeku Muru
Authors: Greenberg Marc L. 
Published: August 2017

U radu se iznose samoglasnički sustavi i nekoliko prozodijskih osobina manje poznatih govora u selima uz rijeku Muru u istočnoj prleštini, zapadnoj međimurštini i južnoj prekomurštini, tj. na području gdje su ta tri dijalekta u dodiru. Uz prikaz nove građe sakupljene terenskim istraživanjem autora, raspravlja se o inovacijama kao rezultatu jezičnoga dodira u daljoj prošlosti i novijem vremenu. Potvrđuje se prijelazna priroda odnosa između međimurštine i prleštine kao i relativnog rascjepa između tih dvaju i prekomurštine. U opažanja o međusobnim utjecajima u novije vrijeme može se uključiti: širenje dvoglasnika tipa ei, ou u južnom smjeru sa strane prekomurštine preko Mure, čuvanje sjeverne granice zamjene stražnjeg u (zamjena pomicanog refleksa praslavenskoga *u), i usporedni razvoj tendencije ukidanja količinskih opreka i zamjeni inherentnim oprekama u naglašenom slogu, što ima za posljedicu nastanak novih dvoglasnika tipa ie, uo kao zamjene nekadašnjih kratko naglašenih srednjih samoglasnika.
Scenski kontekst "Komedija" Nikole Nalješkovića
Authors: Mrdeža Antonina Divna 
Published: August 2017

Mnogim se tekstovima različite generičke pripadnosti u starijoj hrvatskoj književnosti prepoznaju žanrovski poticaji iz talijanske književnosti. Kad je riječ o Nalješkovićevim pastirskim prizorima, jednostavnim pastoralnim podvrstama (u rukopisima naslovljenim "Komedije", s rednom oznakom od I. do IV.) književna povijest uglavnom spominje kao izvore eklogu i pastoralu. Postojanje brojnih i pastoralnih i ekloških elemenata u Nalješkovićevim tekstovima pruža dovoljno opravdanja za takvo gledanje, ali zagledanje na teatarsku scenu susjedne nam Italije, koja je, znamo, u to vrijeme nudila novine cijenjene i na domaćoj sceni i njegovane u skladu s našim mogućnostima, otkriva i nešto drugo u pastoralnoj domeni o čemu se kod nas nedovoljno vodilo računa. Naime, Italija je posjedovala scensku tvorevinu međuigara (intermediji, intermezzi, intromessi), iznimno dobro primljenu kod publike. Uvodile su se u međučinove predstava, te na mjesto prologa i epiloga. Ta pastoralna podvrsta mogla je utjecati i na Nalješkovićeve pastirske prizore, a potvrde za tu tvrdnju pronalazimo u njegovim tekstovima: Prvo, svi Nalješkovićevi pastoralni prizori doista su kratke slike iz života arkadijske zajednice ili su kratki mitološki prizori također pastoralnog ugođaja (Parisov sud primjerice), poput onih iz XV. st. kojima se divilo i s kojima se poistovjećivalo talijansko gledateljstvo. Drugo, pjesme vila, satira i pastira neizostavan su dio svakoga prizora, kao i igra odnosno ples. Neprestane napomene autora u škrtim didaskalijama to potvrđuju, ali i izbor stiha: potencijalne pjevne dionice su u osmercima. Treće, pastirski prizori Nalješkovićevi imaju i elemenata komike tamo gdje imamo tanko izdiferenciran sloj rustikalnog i građanskog. Imamo potvrda i u talijanskom teatru da komički elementi nisu posve izostavljani ni iz čistih idila. Četvrto, utjecaj slikovitosti intermedija očituje se i u simetričnosti scena kakve vidimo na oslikanim prizorima (skicama) za pozornicu. Primjerice, broj lica koja se pojavljuju na sceni simetričan je i uglavnom je riječ o 4 vile i četiri pastira ("Komedija I"), tri vile i tri pastira ("Komedija II"), vila i sudac, četiri pastira, četiri satira ("Komedija III"), osam mladaca i osam vila (po svoj prilici u "Komediji IV"). Oku ugodan prizor morao se bazirati na skladu simetričnih brojeva. Osnovni prigovor koji se može postaviti tezi utjecaja međuigara na pastirskie prizore jest nedostatak teksta u međuigrama, ali intermedij popularne priče o Amoru i Psihi, koja se temelji na tekstu, dokazuje da to nije bila zakonitost. Međuigre su dobivale na važnosti kroz čitavo XVI. stoljeće da bi se na koncu utopile u pastoralno-mitološku scenu barokne melodrame u Italiji. Čini se da bitno drukčije nije bilo ni kod nas: usporedimo li obilježja (tematiku, formu, atmosferu, izražajna sredstva) domaćih pastirskih prizora i domaće barokne melodrame, uvidjet ćemo prilično sličnu sliku i njihov međusobni odnos.
Dopune "Jadranskim etimologijama" Vojmira Vinje. Prvi prilog
Authors: Vuletić Nikola 
Published: August 2017

Akademik Vojmir Vinja izdao je u razdoblju od 1998. do 2004. godine tri sveska Jadranskih etimologija - Jadranskih dopuna Skokovu etimologijskom rječniku, pozivajući istovremeno mlađe generacije jezikoslovaca na sustavno obogaćivanje i reinterpretaciju korpusa. Ovaj prilog prvi je naš odgovor na poziv Učitelja. Dopune koje ovdje donosimo temelje se na korpusu što smo ga prikupili tijekom terenskih istraživanja na zadarskim otocima i obali, te na istraživanju spisa zadarskih i rapskih bilježnika iz XIV. i XV. st. provedenih uglavnom nakon objavljivanja posljednjeg sveska Vinjina djela (2004. godine). Osim toga, donose se novi etimološki prijedlozi za neke likove koje je Vinja već obradio, kao i etimološki prijedlozi za dosad neobrađene likove.
Andrija Kačić Miošić i njegovi prosvjetiteljski i jezični prinosi
Authors: Musa Šimun 
Published: August 2017

U povijesti hrvatske književnosti i kulturne djelatnosti uopće Andriji Kačiću Miošiću i njegovoj Pismarici – Razgovoru ugodnom naroda slovinskog pripada izuzetno važno mjesto. Andrija Kačić Miošić – Starac Milovan djeluje u 18. stoljeću ističući se u mnogim oblicima rada – od svećeničkog, ﬁlozofskog, pedagoškog do povijesnog i književno-spisateljskog. Međutim, prosvjetiteljska zadaća njega je zaokupljala više od svega i upravo će u tom poslu postići i najviše uspjeha. Osim toga, njegovi jezični prinosi ostvareni Razgovorom ugodnim naroda slovinskoga rasvjetljuju i povezuju dopreporodno i preporodno doba pokazujući ostvarenu razinu naše jezične homogenosti – svojevrsnu standardizaciju hrvatskog jezika u 18. stoljeću.
Recepcija Andrije Kačića Miošića u zadarskoj periodici na hrvatskom jeziku u 19. stoljeću
Authors: Rados Zvjezdana 
Published: August 2017

U periodici na hrvatskom jeziku koja je u 19. st. izlazila u Zadru zamjetan je interes za život i djelo književnika i prosvjetitelja 18. st. fra Andrije Kačića Miošića. Jer - model kačićevske prosvjetiteljske praktičnoodgojne literature nadavao se kao idealno sredstvo za postizanje hrvatskih narodnopreporodnih ciljeva u Dalmaciji, a devetnaestostoljetna zadarska glasila na hrvatskom jeziku - počevši od Zore dalmatinske, preko Narodnog lista do Iskre - izrazito su preporodnog i pučkoprosvjetiteljskog karaktera. Recepcija Andrije Kačića Miošića u tim glasilima, pa i nekim drugim zadarskim periodicima (u Katoličkoj Dalmaciji i Hrvatskoj, ili primjerice u službenom listu Smotra dalmatinska), zapaža se na nekoliko razina: 1. u samoj programskoj koncepciji i pučko kačićevskoj orijentaciji cijeloga glasila - kao što je to zamjetno u Zori dalmatinskoj za Kuzmanićeva uredništva te još naglašenije u Iskri Nikole Šimića, posebno u njenom prvom tečaju; isto tako u Sundečićevoj Zvijezdi i Matičinu Narodnom koledaru - ili bar jednoga njegova dijela, najčešće podlistka (Narodni list, Smotra dalmatinska i dr.); 2. u prevladavajućem književnom modelu u toj periodici (model kačićevske realističko-racionalističke prosvjetiteljske literature jest upravo paradigmatski); 3. u brojnim književno-povijesnim i prigodnim člancima, raspravama i studijama o životu i djelu Kačića Miošića te u kritičkim osvrtima na njega (posebno je vrijedno istaknuti radove Stjepana Ivičevića u Zori dalmatinskoj, Nikole Šimića u Iskri te Petra Kasandrića u Iskri i Smotri dalmatinskoj); 4. u osvrtima na izdanja Kačića ili na pojedine publikacije njemu posvećene (primjerice u Iskri na Ribolijev Vjenčić Milovanu, 1885.); 5. u pjesmama prigodnicama povodom Kačićevih obljetnica ili pri podizanju spomenika (u Narodnom listu, u Iskri); 6. u publiciranju Kačićevih pjesama (Narodni list, Hrvatska).
Natuknice o naglasku imenica u dativu i lokativu jednine u nekim govorima s novoštokavskim naglasnim sustavom kao smjernice za standardizaciju hrvatskoga jezika
Authors: Benić Mislav 
Published: August 2017

U radu se uspoređuje naglasak u lokativu i dativu jednine kakav propisuju hrvatske gramatike s naglaskom u istim oblicima u nekoliko štokavskih govora. Na temelju istraženih govora pokušava se i donekle razjasniti razjedinjenost gramatika u pogledu rekcije prijedloga prema. Utvrđuje se da je razlika između dativa i lokativa u većini štokavskih govora očuvana samo rudimentarno. Što se tiče prijedloga prema, uviđa se težnja da u onim govorima kod kojih postoji razlikovanje dativa i lokativa, kratke jednosložne osnove n. p. c a-vrste imaju s tim prijedlogom silaznu, a duge osnove uzlaznu intonaciju. Na kraju se rada daje nekoliko razloga za ukidanje i protiv ukidanja lokativa.