bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calculating the Expected Net Benefit of Sampling for Survival Data: A Tutorial and Case Study
Authors: Vervaart Mathyn 
Published: October 2024

The net value of reducing decision uncertainty through collecting additional data is quantified by the expected net benefit of sampling (ENBS). The ENBS is the difference between the population-level expected value of sample information (EVSI) for the data collection exercise and the costs associated with the data collection. ENBS calculations for studies that collect survival data are complicated by the need to take into account censoring, and this has limited the application of value-of-information analysis in this setting. In this tutorial article, we present a general-purpose algorithm for calculating the ENBS for a study that collects survival data along with a step-by-step implementation in R. The algorithm is based on recently published methods for simulating survival data and computing EVSI that do not rely on the survival data being from a distribution with any particular parametric form and that can take into account any arbitrary censoring process. We illustrate the method using a real-life case study drawn from an appraisal of pembrolizumab plus axitinib for treating advanced renal cell carcinoma in which the initial decision was informed by immature survival data. Highlights The net value of reducing decision uncertainty by collecting additional data is quantified by the expected net benefit of sampling (ENBS). This tutorial presents a general-purpose algorithm for computing the ENBS for collecting survival data along with a step-by-step implementation in R. The algorithm is based on recently published methods for simulating survival data and computing expected value of sample information that do not rely on the survival data to follow any particular parametric distribution and that can take into account any arbitrary censoring process. We demonstrate in a case study based on a previous cancer technology appraisal that ENBS calculations are useful not only for designing new studies but also for optimizing reimbursement decisions for new health technologies based on immature evidence from ongoing trials.
The impact of COVID-19 and the ERS on superannuation savings in Australia
Authors: Robey Michael , Bruhn Aaron 
Published: October 2024

COVID-19 has had a significant economic impact on Australia, and consequently on the superannuation savings of many individuals. To examine COVID-19’s heterogeneous effects across different industries and demographic groups, the impact on superannuation was assessed for 12 representative cameos using a range of Australian data, including Household, Income and Labour Dynamics in Australia (HILDA), ATO, ABS and APRA sources. The marginal impacts of sudden job loss, investment losses, investment switching and participation in the Early Release of Superannuation (ERS) scheme were each investigated in turn. The cameos highlight that some demographic cohorts faced several compounding challenges. For example, many ERS applicants were already facing financial hardship, were more likely to be younger, and faced a higher risk of unemployment. This highlights that COVID-19 has impacted different cohorts in different ways, depending on age, employment status and industry, and family situation, among other factors. JEL Classification: D14, D15, J26, J32
The Associations Between Social Support From Adult Children (SSAC) and the Risk of Later-Life Depression (LLD) Among Rural Older Individuals: A Longitudinal Study Based on 2011 to 2018 China Health and Retirement Longitudinal Study Data
Authors: Xie Shuya , Zhang Li , Zhu Ruikai , Yao Zhentao , Wu Yulong , Huang Jia , Lian Fuzhi , Yang Jun , Xu Xianrong 
Published: October 2024

This study was designed to investigate the implications of perceived social support from adult children (SSAC) on the incidence of later-life depression (LLD) among rural older adults in China. A total of 1762 participants without depressive symptoms and aged ≥60 years at baseline were recruited from three waves (2011, 2013, and 2015) of the China Health and Retirement Longitudinal Study (CHARLS) and followed up until 2018. After following-up for 2–7 years (average 4.6 years), a total of 746 participants (43.2%) were identified with LLD and the overall incidence of LLD was 128.5 per 1000 person-years. Univariate and multiple Cox regression analysis consistently indicated that receiving living care support was the sole form of SSAC that may significantly reduce the risk of LLD in rural older adults in China (HR: 0.81, 95% CI: 0.70–0.95, p = .008). These results may be of assistance in comprehensively understanding the role of SSAC in the mental health of older adults.
Do novel inflammation biomarkers arising from routine complete blood count play a role in patients with systemic lupus erythematosus?
Authors: Gambichler Thilo , Numanovic Zenaida , Apel Imke , Hessam Schapoor , Susok Laura , Xenofon Baraliakos  , Sewerin Philipp 
Published: October 2024

Background Laboratory-based biomarkers accurately presenting systemic lupus erythematosus (SLE) disease activity may have a practical value in clinical routine. As shown in many other conditions, complete blood count (CBC)-derived biomarkers may also play a role in SLE. Objectives We aimed to study for the first time the pan-immune-inflammation value (PIV, monocytes x platelets x neutrophils/lymphocytes) and the more established systemic immune-inflammation index (SII, neutrophils x platelets /lymphocytes) in SLE patients and correlate it with serological and clinical findings including disease outcomes. Methods In this retrospective multicentric investigation, we reviewed the clinical records of 148 SLE who had an available CBC at baseline. The latter served for the determination of the neutrophil-to-lymphocyte ratio (NLR), SII, and the PIV. Control groups were studied as well. Univariable as well as multivariable statistics were employed. Results The values for baseline systemic immune-inflammation biomarkers (SIIB) studied were significantly ( p < 0.0001) higher than those observed in healthy controls but comparable to those obtained from patients with other inflammatory conditions. Multivariable analysis revealed that ANA titer > 1:640 remained the only significant ( p < 0.0001) baseline predictor of SLE flare (odds ratio: 7.6, 95% CI 3.1 to 18.8). Improvement of SLE following treatment was associated with the absence of lymphopenia as well as ANA > 1:640 ( p = 0.041). The SLEDAI-2K significantly correlated with NLR, SII, CRP, lymphocytes, and monocytes only on univariable testing. Conclusions Compared to healthy controls the CBC-based SIIB investigated are significantly increased in SLE patients. However, SIIB do not appear to be useful in managing SLE clinically. Nevertheless, we confirm that higher ANA titers can predict flares of SLE.
Mapping Green Supply Chain Practices: An Extensive Bibliometric Review with the SPAR-4-SLR and TCCM Framework
Authors: Jain Silky , Sharma Dinesh Kumar , Sharma Manisha 
Published: October 2024

Purpose: The growing global awareness of environmental sustainability and the threat of climate change has prompted organisations to embrace green supply chain practices (GSCP) to minimise their ecological footprint and improve their competitive edge. The primary objective of this study is to offer a comprehensive, insightful analysis of the GSCP utilising the TCCM (theory, context, characteristics, and methods) framework. Design/Methodology/Approach: This study conducts an extensive bibliometric analysis, incorporating the TCCM framework and SPAR-4-SLR (Scientific Procedures and Rationales for Systematic Literature Reviews) protocol, to delve into the dynamic field of GSCP spanning 2004 to 2023. Findings: This article offers a nuanced exploration of the intricacies of GSCP research dynamics, shedding light on influential articles, distinguished authors, prominent academic institutions, publication sources and nine key thematic research clusters that have had a substantial impact and propelled this pivotal domain forward. TCCM framework is used to construct an all-encompassing citation network, elucidating five significant domains guided by the theoretical framework. These domains include social and economic theories, resource and strategy theories, innovation and change theories, systems and interdisciplinary theories, and management and organisation theories. Every subcategory within the GSCP realm represents a distinct and unique facet and is supported by an individual theoretical framework and scholarly contribution. Practical Implications: The findings from the bibliometric review yield significant insights for researchers and green supply-chain practitioners. This article aims to guide future research endeavours and policy formulation by evaluating the existing knowledge base and pinpointing diverse research avenues. It underscores the importance of interdisciplinary collaboration among academics from different domains to address the complex aspects of sustainability in supply-chain operations, thus highlighting the multidisciplinary character of green supply-chain research. Originality/Value: To the best of our knowledge, this review study is the first to present a bibliometric analysis of GSCP using the TCCM framework and the SPAR-4-SLR protocol.
Exploring the Experiences, Cultural Values, and Perceptions of Mothers of Hospitalized Newborns in Malawi: An Integrative Review of the Literature
Authors: Kesler Erin , Devido Jessica , Zoucha Richard , Wilson Emma 
Published: October 2024

Introduction: Sub-Saharan Africa has the world’s highest rates of neonatal mortality. Mothers are critical to the survival of these at-risk newborns. The aim of this integrative review is to appraise the published literature on the experiences, cultural values, and perceptions of mothers of hospitalized newborns in Malawi to inform future research. Methods: This integrative review utilizes Whittemore and Knafl’s review model. CINAHL, PubMed, and Academic Search Elite databases were searched. Results: Five summarizing themes were identified across ten articles relating to the mother as a caregiver, experiences of mother as a caregiver, cultural observations and perceptions of the mother, influence of others on the mother, and discrimination and stigma. Discussion: Mothers’ experiences of having a newborn requiring hospitalization in Malawi are complex. Results indicate a need for more studies to understand the experiences of mothers of newborns requiring hospitalization in Malawi in order to provide culturally congruent newborn care.
ENO1 as a Biomarker of Breast Cancer Progression and Metastasis: A Bioinformatic Approach Using Available Databases
Authors: Giannoudis Athina , Heath Alistair , Sharma Vijay 
Published: October 2024

Background: Metabolic reprogramming is one of the hallmarks of cancer, and in breast cancer (BC), several metabolic enzymes are overexpressed and overactivated. One of these, Enolase 1 (ENO1), catalyses glycolysis and is involved in the regulation of multiple signalling pathways. Objectives: This study aimed to evaluate in silico the prognostic and predictive effects of ENO1 expression in BC. Design: This is a bioinformatic in silico analysis. Methods: Using available online platforms (Kaplan–Meier [KM] plotter, receiver operating characteristic curve [ROC] plotter, cBioPortal, Genotype-2-Outcome [G-2-O], MethSurv, and Tumour–Immune System Interaction Database [TISIDB]), we performed a bioinformatic in silico analysis to establish the prognostic and predictive effects related to ENO1 expression in BC. A network analysis was performed using the Oncomine platform, and signalling, epigenetic, and immune regulation pathways were explored. Results: ENO1 was overexpressed in all the analysed Oncomine, epigenetic, and immune pathways in triple-negative, but not in hormone receptor–positive BCs. In human epidermal growth factor receptor 2 (HER2)-positive BCs, ENO1 expression showed a mixed profile. Analysis on disease progression and histological types showed ENO1 overexpression in ductal in situ and invasive carcinoma, in high-grade tumours followed by advanced or metastasis and was linked to worse survival. High ENO1 expression was also associated with relapse-free, distant metastasis-free and overall survival, irrespectively of treatment and was mainly related to basal subtype. Conclusion: ENO1 overexpression recruits a range of signalling pathways during disease progression conferring a worse prognosis and can be potentially used as a biomarker of disease progression and therapeutic target, particularly in triple-negative and in ductal invasive carcinoma.
Blunt Thoracic and Abdominal Aortic Injury in Multiple Trauma: A Case Report
Authors: Akinaga Seishiro , Maruhashi Takaaki , Oi Marina , Mishima Toshiaki , Miyaji Kagami , Asari Yasushi 
Published: October 2024

Background Blunt abdominal aortic injury (BAAI) is rare among traumatic aortic injuries, and further complications of blunt thoracic aortic injury (BTAI) have never been reported. Case Presentation A man in his 80s presented to our hospital following a motor vehicle accident. Pan-scan contrast-enhanced CT showed a thoracic aortic isthmus injury (Grade III), an abdominal aortic injury (Grade IV) with extravasation of contrast media at the level of the fourth lumbar vertebra. Endovascular abdominal aortic repair was performed on the same day and a thoracic endovascular aortic repair for BTAI was performed 11 days after admission. The patient had a good postoperative course and was discharged without complications. Conclusion This report presented a rare case of BTAI complicated with BAAI. The timing of intervention for aortic injury should be determined based on urgency and other organ damage.
An Exercise and Wellness Behavior Change Program for Solid Organ Transplant: A Clinical Research Protocol for the Transplant Wellness Program
Authors: Sim Jenna A. P. , Perinpanayagam Maneka A. , Bahry Vanessa , Wytsma-Fisher Kathryn , Burak Kelly W. , Isaac Debra L. , Mustata Stefan , Culos-Reed S. Nicole 
Published: October 2024

Background: Exercise prehabilitation is an evidence-based, safe, and effective method to increase quality of life, physical fitness and function, and post-surgical outcomes in solid organ transplant (SOT) patients. However, few prehabilitation programs for SOT patients exist in practice. Furthermore, there is a lack of multimodal prehabilitation programs that include behavior change support. To address this need, the Transplant Wellness Program (TWP) was designed. Objectives: The objective of the TWP is to assess both the effectiveness and implementation of a comprehensive and multimodal exercise and wellness behavior change intervention for patients undergoing kidney or liver transplant. Design: The TWP is a hybrid effectiveness-implementation trial consisting of exercise and wellness behavior change support. Patients: Individuals who are in evaluation or listed for kidney or liver transplant in Southern Alberta, Canada. Measurements: The primary outcomes of self-reported exercise and quality of life are assessed at intake, post-exercise intervention, 6 months post-intake, 12 weeks post-transplant, and annually for 5 years after program completion. Functional fitness measures will be assessed at intake, post-exercise intervention, 12 weeks post-transplant, 6 months post-intake, and 1-year post-intake. The reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework is used to determine the impact of TWP at the individual and health care system level. Methods: Recruitment began in November 2023 and will continue until November 2028. Participants take part in a 12-week exercise intervention and are offered individualized and group behavior change support. Continued exercise support is offered through maintenance classes after the completion of the 12-week intervention. Limitations: The design of the hybrid effectiveness-implementation trial with a single experimental group will not allow for comparisons to a control or usual care group, potentially impacting internal validity. Differences in number of participants between organ groups (kidney vs liver) and cohorts (pre-transplant vs post-transplant) will likely be uneven, requiring consideration when running and interpreting analyses. Conclusions: The TWP aims to support patients throughout the transplant journey through a multimodal and comprehensive exercise and wellness behavior change program. Results from this study will determine the effectiveness of the program and inform future scale-up and sustainability. Trial registry number: NCT06367244.
Exploring the evolution of eHealth in disease management: A bibliometric analysis from 1999 to 2023
Authors: Chen Suyu , Li Min , Chen Yiping , Zhang Yujing , Li Yongli , Tai Xiantao , Zhang Xinghe 
Published: October 2024

Objective In the digital age, eHealth is vital in modern healthcare, impacting medical services and public health. Despite its potential in disease management, a comprehensive bibliometric analysis is lacking. This study utilizes bibliometric methods to explore the evolution of eHealth in disease management from 1999 to 2023, aiming to discern the research status and trends. Methods A literature search was conducted using the Web of Science Core Collection (WOSCC) database. Publications and journals were quantitatively analyzed using Microsoft Office Excel 2023. Country/institution/author collaborations and keyword co-occurrences were analyzed using VOSviewer. CiteSpace was employed to analyze the citation bursts of reference. A global distribution network of publications was constructed and thematic trends were analyzed using R package “bibliometrix.” Results The study identified 1763 articles on eHealth in disease management. Since 2011, there has been a notable increase in publications, with the United States (n = 391, 22.08%) and the University of Sydney (n = 60, 3.40%) as leading contributors. High-quality journals primarily publish this research. Globally, 9631 authors contributed, with Chavannes, Niels H being the most prolific (n = 23). Author co-citation analysis indicated Eysenbach, G as the most cited (n = 336). Research currently focuses on developing a comprehensive eHealth framework, optimizing mHealth for chronic diseases, improving eHealth intervention trial reporting, assessing social factors in eHealth literacy, and examining telemedicine's role during the Covid-19 pandemic. Conclusion This study offers a comprehensive overview of eHealth research in disease management. eHealth's potential in disease prevention and treatment is significant. To enhance eHealth's impact, international collaboration, technological innovation, tailored intervention trials, addressing the digital divide, and solving legal and ethical issues are crucial. This study will guide future research endeavors, with the goal of enhancing eHealth's benefits and expanding its accessibility to a wider patient base.
Introducing a systematic and sustainable patient safety oversight function in a U.K. arms-length healthcare body
Authors: Southall Sara , Patrick Hannah , Harris Kevin , Bird Chris 
Published: October 2024

Background The healthcare landscape is experiencing a profound period of change with accelerating developments in medical research, new treatments, care delivery and the use of innovative technology to meet the challenges of delivering care. These changes offer opportunities but as with all innovation, require careful management to reduce the likelihood of harm and error. Objective The National Institute for Health and Care Excellence (NICE) has set out to introduce an adaptable, sustainable and systematic patient safety oversight group to ensure that patient safety is embedded at an organisation level supporting the healthcare system to overcome challenges and deliver high quality care, safely implementing the latest innovations in a timely manner. Method The patient safety oversight group was established through a scoping exercise, led by the senior responsible officer and a small project team. The article sets out the methods used, including extensive internal engagement through structured interviews with senior leadership teams, purposive sampling, data synthesis and reporting. An overview of the group is given and considerations for promoting patient safety information flows and optimising the use of safety signal intelligence are made. Conclusion Through reflection on changing needs within and surrounding the organisation, along with patient safety and complexity literature, NICE has developed an adaptable, systematic and sustainable model for managing patient safety. In addition to generating learning within NICE, the process highlights opportunities for improvement within the patient safety system. Result NICE has developed an adaptable, systematic and sustainable model for managing patient safety.
Translation and Validation of the Diabetes Knowledge Questionnaire in Indonesian Patients With Type 2 Diabetes
Authors: Cahyaningsih Indriastuti , Rokhman M. Rifqi , Maziyyah Nurul , Niamuzisilawati Eva , Taxis Katja , Denig Petra 
Published: October 2024

Purpose The purpose of the study was to translate and cross-culturally adapt the 24-item Diabetes Knowledge Questionnaire (DKQ) for Indonesian patients with type 2 diabetes (T2D) and evaluate its psychometric properties. Methods Forward-backward translation, adaptation involving 7 experts, and pretesting to develop the Indonesian version of DKQ were conducted. Psychometric analysis was carried out among T2D patients from 40 primary health care centers in Indonesia. Known-group, convergent and discriminant validity, internal consistency and test-retest reliability were assessed. Additionally, a descriptive item analysis was conducted. Results In total, 39 patients participated in the pretesting and 304 patients in the validation process and descriptive analysis. Of the 24 items, 2 were adjusted during the adaptation process, and 1 item was deleted because it did not adequately reflect the original item. Known-group validity was demonstrated because patients with younger ages, higher educational levels, and longer diabetes duration had significantly higher DKQ scores. Convergent validity was demonstrated by a significant positive correlation of the DKQ scores with overall treatment satisfaction. The 23-item DKQ Bahasa Indonesia showed satisfactory internal consistency (Cronbach’s α = 0.73; omega total = 0.72) and good test-retest reliability (intraclass correlation coefficient = 0.87 in a sample of 27 patients). No floor and ceiling effects were found in the item analysis. Conclusion The study demonstrates adequate validity and reliability of the 23-item DKQ Bahasa Indonesia for assessing diabetes knowledge in Indonesian primary care patients with T2D. This instrument can be used to identify room for improvement and develop diabetes education programs.