bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cartilage-Specific Matrix and Integrin Expression in Three-Dimensional Articular Chondrocyte Cultures Overexpressing Human Interleukin-10
Authors: Müller Riccarda D. , John Thilo , Kohl Benjamin , Feldner Anja , Zreiqat Hala , Ertel Wolfgang , LaFace Drake , Hutchins Beth , Oberholzer Andreas , Schulze-Tanzil Gundula 
Published: October 2017

Interleukin (IL)-10 overexpression inhibits joint inflammation, however the effect of high local concentrations of IL-10 on chondrocyte homeostasis remains unclear. The aim of this study was to determine the effects of IL-10 overexpression on cartilage matrix production in three-dimensional (3D) chondrocyte cultures.Human articular chondrocytes were transduced with adenoviral vectors alone (adv/empty) or by vectors either overexpressing enhanced green fluorescence protein (adv/EGFP) or human IL-10 (adv/hIL-10) before their transfer to a 3D culture system. Non-transduced chondrocytes were used as controls. The expression of IL-10 or EGFP was confirmed using ELISA or flow cytometry. Chondrocytes synthesis of collagen types II and I, aggrecan, fibronectin and β1-integrin was determined over a period of 14 days post transduction using flow cytometry or immunohistochemistry.adv/EGFP or adv/IL-10 transduced chondrocytes expressed EGFP or secreted IL-10 detectable over the 2 weeks culture period. No suppression of collagen type II, aggrecan or β1-integrin synthesis by IL-10 overexpression was found and the deposition of collagen type I and fibronectin remained unaffected compared to the controls.IL-10 overexpression does not impair key features of chondrocytes differentiated phenotype (e.g. collagen type II and aggrecan expression) suggesting the potential use of IL-10 for gene therapeutic approaches in the joint.
Skin Infection by Coagulase Negative Staphylococci as a Potential Triggering Factor for Cutaneous Leukocytoclastic Vasculitis
Authors: Thonhofer Rene , Trummer Markus , Siegel Cornelia , Uitz Elisabeth 
Published: October 2017

Introduction Leukocytoclastic vasculitis (LV) is a necrotising vasculitis of the small dermal blood vessels, clinically presented as palpable purpura. It is a heterogeneous disorder often limited to the skin but which may involve other organs. LV might be a serious drug reaction, caused by bacterial and viral infections, or less commonly a manifestation of systemic vasculitic syndromes. Case Reports Three patients were admitted to our institution with petechiae and palpable purpura. The cutanous lesions were affecting the lower limbs and in one patient also the upper extremities and the trunk. The diagnosis of leukocytoclastic vasculitis was made based on clinical and histopathological findings. Systemic involvement was excluded, as was connective tissue disease. Clinical examination revealed ulcers on the legs of each patient. Smears from those ulcers were taken and investigated for micro organisms. Culture results showed infection with coagulase negative staphylococci. Systemic signs of sepsis were absent; therefore the infections were treated locally. Two patients developed necrotic blisters during the first week of hospitalisation. To avoid further vasculitic complications steroids were administered parenterally and LV lesions diminished in all patients within ten days. Conclusion Drugs and connective tissue disease were ruled out as triggering factors of LV in the patients reported on. Therefore, it was concluded that superantigens produced by the coagulase negative staphylococci were responsible for LV.
Radiological and Magnetic Resonance Imaging Findings in the Sacroiliac Joints in Patients with early Spondylarthropathy
Authors: Luukkainen Reijo , Virtanen Kimmo O.J. , Luukkainen Pekka 
Published: October 2017

Objective To compare the radiological (X-ray) and magnetic resonance imaging (MRI) findings in the sacroiliac (SI) joints in patients with early spondylarthropathy (SpA). Methods Forty consecutive HLA B27 antigen positive patients with early SpA and inflammatory low back pain (LBP) were studied. Their SI joints were investigated by posterior anterior plain X-ray and MRI. Results The X-ray and MRI examinations gave similar results in the SI joints in 24 patients, whereas they differed in 16, this difference being significant (p = 0.007). In those 16 patients, in whom the findings differed, the X-ray findings were normal but MRI showed sacroiliitis which was bilateral in 13 and unilateral in 3 patients. The kappa coefficient between these investigations was 0.346, showing poor agreement. Conclusion These results indicate that MRI may considerably improve the diagnosis of sacroiliitis in HLA B27 antigen positive patients with early SpA and inflammatory LBP.
The Impact of Planned Visits on Patients with Type 2 Diabetes Mellitus
Authors: Nuovo Jim 
Published: October 2017

Objectives To investigate whether planned visits improve glycemic, blood pressure and lipid control among patients with type 2 diabetes mellitus (DM). Methods The study was conducted from July 2007 to February 2008 at a primary care clinic in Rancho Cordova, California. One hundred eighty-three patients were invited to come to a planned visit. On the day of the visit, they were provided a copy of their most recent test results and information on American Diabetes Association recommendations for A1C, lipid, and blood pressure control. Afterwards, they met with their physician for a 15-minute focused appointment. Finally, they met with a diabetic nurse educator. There was no subsequent contact with the nurse educator after the planned visit. We compared the baseline measurements to those from a follow-up visit with the primary care provider at a follow-up over a 6 month period. The comparison group in this study were those who did not accept the invitation for a planned visit. Their outcomes were monitored over the same time horizon. Results One hundred eighty-three patients attended one of a total of five planned visit sessions. There were 212 patients in the comparison group. There were no significant differences for the measured baseline characteristics. There were significant improvements in A1C, LDL-C, and diastolic blood pressure control in the planned visit group. The mean A1C change was –0.61% (95% confidence interval, –0.28, –0.70); P < 0.001). The mean LDL-C change was -8.8 mg/dL (95% confidence interval, –12.2, 6.1); P < 0.05. The mean diastolic blood pressure change was -2.0 mmHg (95% confidence interval, –4.7, 6.7); P < 0.05. Patients who participated in a planned visit also reported a significantly higher frequency of self-care behaviors and greater understanding about diabetes care. Discussion Planned visits led to improvements in glycemic, lipid and blood pressure control over a 6 month observation period. Patients attending planned visits also reported improvements in self-care behaviors and a greater understanding about diabetes care.
Insulin Resistance and Hyperinsulinemia in Patients with Chronic Liver Disease and Hepatocellular Carcinoma
Authors: Donadon Valter , Balbi Massimiliano , Perciaccante Antonio , Casarin Pietro , Zanette Giorgio 
Published: October 2017

ObjectivesTo investigate the role of insulin resistance (IR) and insulin plasma levels (IRI) in patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC).MethodsWe recruited the following patients: 125 with HCC, 128 with liver cirrhosis (LC) and 133 with chronic hepatitis C (CHC). IR was assessed by the HOMA-IR method. To define IR and hyperinsulinemia we selected as a cut-off level, the value of the 80th percentile for HOMA-IR (2.72) and IRI (11.18) in 113 healthy subjects.ResultsThe mean levels of HOMA-IR and IRI increase progressively among CHC (2.7 ± 2.9 and 11.5 ± 10.5, respectively), LC (5.4 ± 4.5 and 17.6 ± 11.2) and HCC (6.4 ± 9.8 and 18.2 ± 18.8). In the upper quintiles for HOMA-IR and IRI, the frequency of patients in the LC and HCC groups was twice as much in CHC cases. HCC with DM2 have the greatest percentage above the 80th percentile of HOMA-IR, their quintiles distribution is inverted and HOMA-IR mean values are significantly higher in comparison with HCC without DM2 cases.DiscussionOur study shows that the association between IR and CLD begins in the early stages of liver fibrosis. DM2 increases HOMA-IR and IRI mean levels in HCC patients and these metabolic factors could play a major role in the link between diabetes mellitus and hepatocarcinoma.
The Clinical Efficacy and Safety of Glucagon-Like Peptide-1 (GLP-1) Agonists in Adults with Type 2 Diabetes Mellitus
Authors: Brice Kira R. , Tzefos Maria K. 
Published: October 2017

Objective To review the efficacy and safety of glucagon-like peptide-1 (GLP-1) agonists to determine their role in type 2 diabetes mellitus (T2DM). Data Sources A Medline search was conducted using the keywords exenatide, liraglutide, glucagon-like peptide-1, type 2 diabetes mellitus, hyperglycemia, pharmacokinetics, pharmacology and safety. Study Selection All identified articles written in English were evaluated with priority given to controlled, randomized trials including human data. References of identified published trials were reviewed for additional trials to be included in the review. Data Synthesis Exenatide and liraglutide are GLP-1 agonists approved for the treatment of T2DM. Several randomized, active and placebo controlled trials examining the efficacy and safety of exenatide and liraglutide both as monotherapy and in combination therapy have been conducted. Both agents have demonstrated improved glycemic control in addition to weight loss and increased beta-cell function. The most common adverse effects are gastrointestinal in nature and appear to be transient. Conclusion It appears exenatide and liraglutide are safe and effective in the treatment of T2DM and may exhibit effects that make them preferred over other anti-diabetic medications.
Adipocytokines as Influenced by Family History of Type 2 Diabetes and Smoking in Non-Diabetic Subjects
Authors: Al-Daghri Nasser M. , Al-Attas Omar S. , Al-Onazi Mohammad , Al-Rubeaan Khalid , Al-Najjar Hussein 
Published: October 2017

Background The controversial roles played by major adipocytokines such as resistin, leptin and adiponectin in obesity and insulin resistance were extensively studied. This study aims to explore for the first time the possible effect of a family history of type 2 diabetes mellitus and smoking on non-diabetic individuals and associations to other metabolic parameters. Results In females there were significantly lower adiponectin levels among those with family history compared to those without (p 0.045); BMI and family history of type 2 diabetes contributed significantly to adiponectin levels with 43.7% variance (r 2 19.1; p 0.018). In males there was a significant decrease in resistin levels of those with smoking history (p 0.05). Linear regression showed a correlation between log resistin and LDL, and ApoA1 in all subjects (p-values 007, 0.0009 and R 2 0.12, 0.08 respectively). Conclusion This study showed for the first time that among the three adipocytokines, adiponectin was the only one to exhibit variations in females alone with regard to a family history of type 2 diabetes; the rest were independent of smoking. This study supports the view that adiponectin is a potential risk marker for type 2 diabetes.
The Sustainable Development Goals and the systems approach to sustainability
Authors: Barbier Edward B. , Burgess Joanne C. 
Published: October 2017

Abstract
The authors explore the link between the systems approach to sustainability and the 17 Sustainable Development Goals (SDGs), which were formally adopted by the UN in 2015. The systems approach depicts sustainable development as the intersection of the goals attributed to three interlinked systems: environmental (or ecological), economic and social. The authors illustrate how each of the 17 SDGs can be characterized as a goal primarily attributed either to the environmental, economic or social system, and as suggested by the systems approach, there may be important tradeoffs in attempting to attain all these goals simultaneously. By adopting standard methods of the theory of choice and welfare under imposed quantities, the authors show that is possible to measure the welfare effects of an increase in the indicator level for one SDG by identifying the tradeoffs that occur with achieving another goal. They present a quantitative assessment of current progress and tradeoffs among the 17 SDGs, using a representative indicator for each goal. They then conduct a preliminary welfare analysis of these tradeoffs through employing the approach developed in this paper. Although this analysis focuses on the potential tradeoffs among SDGs, the approach could also be applied to show complementarities, or “winwins”, in simultaneous progress among two or more SDGs. Such an analysis can help in the design of appropriate policy interventions to achieve specific SDGs, minimizing the potentially negative knock-on effects on some goals whilst capitalizing on the positive win-win impacts on other SDGs.
RESPOTA DO FUNGO MICORRÍZICO ARBUSCULAR RHIZOPHAGUS CLARUS E ADIÇÃO DE SUBSTÂNCIAS HÚMICAS NO CRESCIMENTO DO TOMATEIRO
Authors: Barbosa da Silva Mylena , Custódio Oliver Fernanda , Sete da Cruz Rayane Monique , Almeida Marchi Bianca , Marques Das Almas Luiz Renato , Alberton Odair 
Published: October 2017

A utilização de fungos micorrízicos arbusculares (FMAs) pode otimizar a produção, uma vez que a simbiose entre o fungo e a planta pode promover o aumento da absorção de nutrientes. O objetivo deste estudo foi avaliar o efeito da inoculação de fungo micorrízico arbuscular e a adição de substâncias húmicas (SHs) na cultura do tomateiro. Para isso, foram avaliados: a densidade dos esporos, a colonização radicular por FMA, a produção de fitomassa, o índice de clorofila e o conteúdo de fósforo na parte aérea. O delineamento experimental foi inteiramente casualizado com quatro tratamentos e cinco repetições em vasos com 3 L de substrato (areia + vermiculita 1:1 v/v, estéril) em casa de vegetação da Universidade Paranaense – UNIPAR, Umuarama, PR. Os tratamentos foram os seguintes: 1 - sem inoculação de FMA e sem adição de SHs, 2 - com inoculação de FMA e sem adição de SHs, 3 - sem inoculação de FMA e adição de SHs, 4 - com inoculação de FMA e adição de SHs. A densidade de esporos, a colonização radicular por FMA, a massa seca da parte aérea e total e o conteúdo de fósforo das folhas foram aumentados significantemente com a inoculação de FMAs e adição de SHs. O índice de clorofila aumentou significantemente a adição de SHs. Conclui-se que com a inoculação de FMAs e adição de SHs promove o crescimento e o aumento do conteúdo de fósforo na planta de tomateiro.
Enkele fiscale aspecten van de vierde tranche
Authors: Burgerhart W. 
Published: October 2017

Enkele fiscale aspecten van de vierde tranche
De auteur gaat in deze bijdrage in op de fiscale effecten van de veranderingen in het huwelijksvermogensrecht per 1 januari 2018. De relatie tussen het huwelijksvermogensrecht en de verschillende heffingswetten is gecompliceerd. Hoewel fiscale aanpassingswetgeving achterwege is gebleven, dient men bedacht te zijn op fiscale neveneffecten van de bedoelde veranderingen.
Os signos da fotografia: um olhar sobre o projeto Êxodos de Sebastião Salgado
Authors: Santos Silvia Spagnol Simi dos 
Published: October 2017

O presente estudo semiótico tem por objetivo analisar os signos inseridos em cinco fotografias do projeto “Êxodos” de Sebastião Salgado, que retrata movimentos migratórios do mundo todo. É possível identificar, por meio das obras, elementos sígnicos do contexto social, político e econômico que apresentam-se de forma clara nas imagens e que retratam a condição humana em forma de signos de denúncia.Palavras-chave: fotografia.; Semiótica;. Sebastião Salgado; Movimentos migratórios.Los signos de fotografía: una ves en el proyecto Êxodos del Sebastião SalgadoEl presente estudio semiótico tiene por objetivo analizar los signos insertados en cinco fotografías del proyecto "Éxodos" de Sebastião Salgado, que retrata movimientos migratorios de todo el mundo. Es posible identificar, por medio de las obras, elementos sígnicos del contexto social, político y económico que se presentan de forma clara en las imágenes y que retratan la condición humana en forma de signos de denuncia.Palabras clave: Fotografía;. Semiótica; Sebastião Salgado; Los movimientos migratorios.The signs of photography: a look on the Êxodos project of Sebastião SalgadoThe present semiotic study aims to analyze the signs inserted in five photographs of the project "Exodus" by Sebastião Salgado, which depicts migratory movements from all over the world. It is possible to identify, through the works, signic elements of the social, political and economic context that are clearly presented in the images and that portray the human condition in the form of signs of denunciation.Keywords: Photography; Semiotics; Sebastião Salgado; Migratory movements.
A contribuição da percepção do Product Placement na atitude frente às marcas: um estudo na série House Of Cards da Netflix
Authors: Paiva Nicolas Marques , Gomes Aline Ribeiro , Barreto Yara Almeida , Reinaldo Hugo Acosta 
Published: October 2017

O objeto de estudo do presente trabalho busca identificar a eficiência do Product Placement (PP). Realizou-se uma pesquisa qualitativa de caráter exploratório junto a audiência da série House Of Cards, que percebeu a presença de marcas e não se mostrou incomodada com o uso desse tipo de publicidade.Palavras-chave: Eficiência; Marcas; Product Placement.La contribución de la percepción del Product Placement en la actitud hacia las marcas: un estudio de la serie de la Netflix, House Of Cards Resumen: El objeto de este estudio buscó determinar la eficacia del Product Placement (PP). Por lo tanto, una investigación cualitativa y exploratoria se aplicó con la audiencia de la serie House Of Cards, que se dio cuenta de la presencia de algunas marcas, y no se muestra para ser molestado por el uso de este tipo de publicidad.Palabras clave: Eficiencia; Marcas; Product Placement.The contribution of the perception of Product Placement in the attitude towards brands: a study in the Netflix’s series House Of CardsAbstract: The object of this study sought to identify the efficiency regarding Product Placement (PP). Therefore, a qualitative and exploratory research was applied with the House Of Cards series' audience, which noticed the presence of some brands, and did not shown to be bothered about the using of this type of advertising.Keywords: Efficiency; Brands; Product Placement.
Les indemnités pour accidents du travail, les bureaux de placement gratuits et la première guerre mondiale (1909-1918)
Authors: Chartier Roger 
Published: October 2017

Voici le troisième d'une série de textes sur la législation québécoise du travail (et sur les services connexes du Ministère du travail) de 1885 à nos jours. Ces notes pourront un jour servir à une histoire plus méthodique des relations du travail au Québec.
Cette série d'articles est la synthèse d'une « Etude analytique et évolutive des services du Ministère du travail et de la législation ouvrière et sociale de la province de Québec, 1885-1952 » préparée par l'auteur à la demande du Ministère, et reproduite ici avec sa permission.
La légalité du boycottage
Authors: Beaulieu M.L. 
Published: October 2017

Notre jurisprudence sur le boycottage vient de s'enrichir d'un arrêt de la Cour suprême. C'est l'affaire de Seafarers International Union of North America, Canadian District v. Joseph Stern (1). L'arrêt porte aussi sur une intéressante question de procédure : la portée de l'article 81a du Code de procédure (2) donnant un mode d'assignation de tout groupement de personnes associées pour la poursuite en commun de fins ou avantages d'ordre matériel, commercial ou professionnel, qui ne possède pas dans la province de personnalité civile collective et n'est pas une société au sens du Code civil.
(1) (1961) S.C.R., p. 682. L'arrêt de la Cour d'appel est rapporté à 1960, B.R., p. 901.
(2) A venir à la Loi 8-9 Eli. II, ch. 90, art. 6, votée à la session de 1959-1960, ce texte faisait partie de la Loi concernant certaines matières spéciales relatives à la procédure. S.R.Q. (1941), ch. 342, originairement la Loi favorisant l'exercice de certains droits, 2 Geo. VI, ch. 96, cotée en 1938.
Certification — Right to Certification for a Sectarian Organization Restricted to Members of the Christian Faith — Right Denied
Authors: MacLean L.A. 
Published: October 2017

Section 10 of the Ontario labour Relations Act, concerning certification of unions, as well as Section 4 of The Fair Employment Practices Act require that a trade union must extend the opportunity of membership and the right incidental to membership, equally and impartially and on the same terms and conditions to persons of all creeds. Any arbitrary or discriminatory denial of these right and opportunities is not only inimical to basic democratic principles but is incompatible wtih the union's obligation as an exclusive bargaining agent to represent all employees in the bargaining unit.
Trenton Construction Workers Association, local No 52, affiliated with the Christian Labour Association of Canada, Applicant, and Tange Company Limited, Respondent; Ontario Labour Relations Board, File No. 20576-60, November 13, 1961. L.A. MacLean, Deputy Vice-Chairman, and Board Members G. Russel Harvey and R.W. Teagle.
Liquidation des affaires et renouvellement de convention
Authors: Cardin Jean-Réal 
Published: October 2017

Un tribunal d'arbitrage décide (majoritairement, l'arbitre syndical étant dissident) de recommander le « statu quo », c'est-à-dire le maintien de la convention collective existante plutôt que d'entendre les représentations des parties sur les points au mandat en vue dun renouvellement de convention. La décision est à l'effet que, la Compagnie devant procéder à sa propre liquidation sous peu et ne retenant plus que deux ou trois employés à son service, il n'y avait pas d'objet à procéder à l'arbitrage selon le mandat qui était le sien.
Chronologie de l'évolution confessionnelle de la CTCC (CSN)
Authors: Chartier Roger 
Published: October 2017

Cette chronologie, qu'a préparée Roger Chartier, doit beaucoup au Procès-verbal de la 39e session du Congrès de la CTCC (Montréal, 25 septembre — 1er octobre 1960), et notamment au Rapport de l'Exécutif de la CTCC sur la confessionnalité rédigé par le secrétaire général, M. Jean Marchand.
L'organisation de l'assurance en matière d'accidents de Travail dans le Québec
Authors: Guay R.-Edgar 
Published: October 2017

L'Institut interuniversitaire belge de Droit social a organisé à Bruxelles, du 8 au 15 juin 1958, le 11e Congrès international de Droit social autour du thème suivant : « Le rôle de l'Etat dans la réglementation du travail et dans l'organisation de la sécurité sociale ». A cette occasion, le professeur R.-Edgar Guay, de l'Ecole de service social de l'Université Laval, a présenté l'étude qui suit sur la législation québécoise en matière d'accidents du travail.
Les relations patronales-ouvrières
Authors: Bernier Paul , Couturier Gérard 
Published: October 2017

Deux diocèses connaissent un développement industriel inaccoutumé avec nécessairement des problèmes délicats de relations patronales ouvrières. Ils ont à leur tête des évêques récemment nommés qui ont tenu à rappeler à leurs fidèles l'enseignement de l'Eglise dans ce domaine.
On trouvera ici des extraits d'une allocution prononcée par S.Exc. Mgr Paul Bernier, archevêque-évêque de Gaspé, lors de l'inauguration d'un centre de loisirs à Murdochville, le 14 décembre 1957, ainsi qu'une partie d'une lettre pastorale que S.Exc. Mgr Gérard Couturier adressait le 25 décembre 1957 à tous les fidèles du diocèse du Golfe St-Laurent.