bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study
Authors: van Vliet Erwin A. , Scheper Mirte , Mills James D. , Puhakka Noora , Szydlowska Kinga , Ferracin Manuela , Lovisari Francesca , Soukupova Marie , Zucchini Silvia , Srivastava Prashant K. , Johnson Michael R. , Lukasiuk Katarzyna , Gorter Jan A. , Aronica Eleonora , Pitkänen Asla , Simonato Michele 
Published: October 2024

AbstractObjectiveStructural epilepsies can manifest months or years after the occurrence of an initial epileptogenic insult, making them amenable for secondary prevention. However, development of preventive treatments has been challenged by a lack of biomarkers for identifying the subset of individuals with the highest risk of epilepsy after the epileptogenic insult.MethodsFour different rat models of epileptogenesis were investigated to identify differentially expressed circulating microRNA (miRNA) and isomiR profiles as biomarkers for epileptogenesis. Plasma samples were collected on day 2 and day 9 during the latency period from animals that did or did not develop epilepsy during long‐term video‐electroencephalographic monitoring. miRNAs and isomiRs were identified and measured in an unsupervised manner, using a genome‐wide small RNA sequencing platform. Receiver operating characteristic analysis was performed to determine the performance of putative biomarkers.ResultsTwo days after an epileptogenic insult, alterations in the levels of several plasma miRNAs and isomiRs predicted epileptogenesis in a model‐specific manner. One miRNA, miR‐3085, showed good sensitivity (but low specificity) as a prognostic biomarker for epileptogenesis in all four models (area under the curve = .729, sensitivity = 83%, specificity = 64%, p < .05).SignificanceIdentified plasma miRNAs and isomiRs are mostly etiology‐specific rather than common prognostic biomarkers of epileptogenesis. These data imply that in preclinical and clinical studies, it may be necessary to identify specific biomarkers for different epilepsy etiologies. Importantly, circulating miRNAs like miR‐3085 with high negative predictive value for epileptogenesis in different etiologies could be useful candidates for initial screening purposes of epileptogenesis risk.
Spontaneous neck hematoma in a hemodialysis patient: A case report
Authors: You Yanhua , Sun Qi 
Published: October 2024

AbstractWe present a 60‐year‐old maintenance hemodialysis patient who initially presented with neck swelling, which was diagnosed as a thyroid issue. Following a hemodialysis session, the swelling in the neck progressively enlarged, leading to respiratory distress and eventual cardiac arrest. During a life‐saving tracheotomy, dark red blood was observed, and endotracheal intubation was urgently performed. Subsequent computed tomography examination identified multiple areas of slight high‐density images in the nasopharyngeal cavity, oropharyngeal cavity, and esophagus. As time passed, the patient's hematoma underwent spontaneous absorption, but signs of recovery were absent. We discuss the rarity, etiology, diagnosis, and management of spontaneous neck hematoma in maintenance hemodialysis patients.
Anti‐glare performance of sol‐gel‐derived spray coatings prepared with various water‐to‐alkoxide ratios
Authors: Kajioka Toshiyuki , Ikegami Koji , Kanai Toshimasa , Kozuka Hiromitsu 
Published: October 2024

AbstractWe fabricated anti‐glare (AG) coatings on glass sheets by spraying alkoxide‐derived silica sols and demonstrated that the water‐to‐alkoxide ratio is one of the key factors for improving AG performance and sol stability. We synthesized silica sols using tetraethylorthosilicate (TEOS), water, nitric acid, and denatured ethanol and sprayed them on sheets of chemically strengthened glass. The molar ratios of water to TEOS (r) were 3, 7, and 14. The sol with r = 7 provided a higher arithmetic‐mean height (Sa), smaller autocorrelation length (Sal), and better optical properties (lower gloss, higher haze, and lower sparkle level) than the sol with r = 3. An excessive amount of water at r = 14 yielded a large Sal and a high sparkle level. As the storage time of the sols increased, higher r values caused a more pronounced increase in Sa. Although none of the sols showed noticeable temporal changes during dynamic light scattering measurements, solutions with higher r values exhibited a more remarkable reduction in the retention time during liquid chromatography with a styrene‐divinylbenzene matrix. Hence, an excessive amount of water was thought to cause hydrophilization of the polymerized species during storage.
Phase diagrams of the BaF2–NdF3 and BaF2–PrF3 systems
Authors: Fedorov Pavel P. , Alexandrov Alexander A. , Luginina Anna A. , Voronov Valery V. , Chernova Elena V. , Kuznetsov Sergey V. 
Published: October 2024

AbstractPhase formation in the BaF2–NdF3 and BaF2–PrF3 systems was studied by solid‐phase annealing at 750°С and syntheses in molten NaNO3 flux at 500°С. We observed the formation of Ba1−хRхF2+х fluorite solid solutions in the aforementioned systems, and these solid solutions underwent ordering to form ordered Ba4Nd3F17 and Ba4Pr3F17 fluorite‐like phases at 917°С and 880°С, respectively.
Implementation of Positive Advanced Recovery Connections in Primary and Secondary Mental Health Care—A Registered Advanced Nurse Practitioner‐Led Initiative
Authors: Cunningham A. , De La Harpe Golden D. , Pink M. , Truszkowska E. , Byrne T. , Murphy C. , Strahann A. , Doyle C. , Kasemiire A. , Frawley T. 
Published: October 2024

ABSTRACTAim(s)This study reports on the implementation of a registered advanced nurse practitioner intervention. Aims include improving access, service user outcomes and integration between primary and secondary care.DesignThis paper reports the quantitative results of a mixed methods implementation study. Qualitative data are reported separately. The PARiHS framework informs the implementation process itself, with considerations for nurses and other healthcare professionals explored.MethodsThe CORE‐OM 34 item rating scale was administered both pre‐ and post‐intervention. Service user attendances in secondary care was monitored.ResultsFindings suggest that the intervention was associated with clinically significant improvements in global or generic distress, reported by service users, as evidenced by changes in the CORE‐OM scores. Access to care was recorded at an average of 3.6 days. Implementation science supported effective and safe implementation with clear governance structures.ConclusionRegistered advanced nurse practice in mental health clinics which provide full episodes of care results in improved integration and may be associated with positive patient outcomes. Implementation science is taught on Irish nursing programmes and this is important if innovative services are to be embedded in the healthcare system.ImpactThe development of a model of care for mental health Registered Advanced Nurse Practitioners at the interface of primary and secondary care settings may be merited. Positive Advanced Recovery Connections may be associated with improving mental health outcomes and bolstering integration of primary and secondary care services. The utilisation of implementation science highlights the need for collaboration with all stakeholders to overcome barriers and recognise facilitators to attain the necessary model of integrated care.Patient and Public ContributionPeer recovery input was provided by members of the service Recovery College, with participation evident in all stages of the project. The psychosocial assessment template was also co‐designed.
What Enables Implementation of Pain Management Interventions in Intensive Care Units and Why: A Realist Evaluation to Refine Program Theory
Authors: Hamadeh Samira , Willetts Georgina , Garvey Loretta 
Published: October 2024

ABSTRACTAimTo uncover perspectives and refine 12 initial program theories concerning the implementation of pain management interventions in intensive care units. Contexts enabling implementation are delineated, and causal mechanisms within these contexts are described.DesignA realist evaluation approach was employed.MethodsFourteen purposively selected Australian nurses of variant roles were virtually and individually interviewed between July and September 2023. Participants were presented with initial program theory, and their perspectives were collated. Data were analysed using an integrated approach of context (C), mechanism (M), outcome (O) categorisation coding, CMO configurations connecting and pattern matching.FindingsPain management interventions work if perceived to be beneficial, precise, comprehensive and fit for purpose. Nurses should be willing to change attitudes and update knowledge. Unit leaders should nurture the development of nurses' professional identity, access to learning, autonomy and self‐determination. Organisations should change the infrastructure, provide resources, mitigate barriers, develop shared mental models, update evidence and institute quality assurance. Adherence to interventions is affected by the outcomes of implementation and intrinsic merits of interventions. In these contexts, confidence is boosted; feelings of empowerment, self‐efficacy, reflective motivation, trust, awareness and autonomy are developed; and capacity is built. Furthermore, frustration from the variability of practices is reduced, accountability and ownership are augmented, yielding positive implementation outcomes.Implications for the ProfessionFindings have implications on nurses, team leaders and organisations concerned with implementation.ImpactThe findings provided a fortified understanding of conditions favouring successful implementation of pain management interventions. Actions should be undertaken at an individual, unit and organisation level to ensure successful implementation.Reporting MethodRAMESES II Reporting Standards for Realist Evaluations informed presentation of study.Patient or Public ContributionIntensive care nurses contributed insights to refine the program theory.
Description of a new endemic Enteromius (Teleostei: Cyprinidae) from the upper Malagarazi in Burundi: Lessons for a protected area under implementation
Authors: Bigirimana Anatole , Kisekelwa Tchalondawa , da Costa Luis M. , Huyghe Charlotte E. T. , Banyankimbona Gaspard , Vreven Emmanuel J. W. M. N. 
Published: October 2024

AbstractRecent collecting efforts in the upper Malagarazi basin (2013–2022) allowed for an integrative study based on qualitative (colour), quantitative (meristic and metric), and barcoding gene [mtDNA, cytochrome c oxidase (COI)] data of specimens similar to Enteromius sp. ‘ascutelatus’, being a previously identified, potentially, new species. Based on these data, the present study confirms its identification as a new species for science, which is here formally described as Enteromius nzigidaherai sp. nov. This new species belongs to the group of Enteromius species for which the last unbranched ray of the dorsal fin is flexible and devoid of serrations along its posterior edge. This species has a horizontal series of black spots at the midlateral level of the sides. Three congeneric species, known from the Congo basin sensu lato, with two of them also found in the upper Malagarazi basin, are most similar to it. However, E. nzigidaherai sp. nov. is distinguished from the two sympatric upper Malagarazi species, that is, E. quadrilineatus and E. lineomaculatus, at least by two meristics and two morphometrics. It is also distinguished from E. urostigma, known from the upper Congo basin, by two meristics and one, apparently related, morphometric. In addition, a barcoding (mtDNA, COI) study revealed that the specimens of E. nzigidaherai sp. nov. form a well‐supported, separate lineage, with a K2P genetic distance of more than 10% with specimens identified as E. quadrilineatus and E. lineomaculatus, both originating from the upper Malagarazi basin and for which tissue samples were available. Finally, the new species was found to be endemic to the upper reaches of two left bank affluents of the upper Malagarazi basin: the Muyovozi and the Kinwa. However, both affluents are threatened by human activities, which seem to have resulted in its local disappearance as recent intensive collecting efforts in the latter affluent have remained unsuccessful. The species should thus be considered Critically Endangered (CR) according to IUCN criteria B1ab(ii,iv)c(i,iii). Therefore, it is hoped that the present description draws renewed attention to the importance of aquatic protection in the region by highlighting the need for the effective establishment of the Malagarazi Nature Reserve and concern for its optimal delimitation to efficiently protect the entire ichthyofauna of the upper Malagarazi, without excluding the fish species confined to its affluent rivers.
Estimates of life‐history and growth parameters of exploited fish species in lakes Edward and George: Implications on exploitation status, population dynamics, management, and conservation of native species
Authors: Musinguzi Laban , Kamya Ashiraf , Nsega Monic , Natugonza Vianny , Okello William , Snoeks Jos , Van Steenberge Maarten 
Published: October 2024

AbstractAdequate knowledge is essential for responsible inland fisheries. However, many inland fisheries lack monitoring, and therefore, decision‐making for fisheries management is not reliable. In this paper, we used data from surveys and literature to estimate the life‐history and growth parameters of 16 exploited fish stocks in the Ugandan part of Lake Edward and Lake George (East Africa). The estimated parameters are pivotal indicators of fish stock status, particularly in data‐poor fisheries. The estimated parameters included maximum length (Lmax) and mean length (Lmean) as indicators of size structure in experimental and commercial catches, coefficients of length–weight relationships, length at 50% maturity (Lm50), fecundity, von Bertalanffy parameters, total mortality (Z), and natural mortality (M). These parameters were estimated using empirical formulae, statistical methods, and analyses of length frequencies. Only two stocks of semutundu Bagrus docmak exhibited significant and increasing trends in Lmax (Lake Edward) and Lmean (Lake George). The estimates for the remaining parameters were consistent with those in FishBase and other literature resources, either for the same species or related species. This consistency indicates their reliability for application in decision‐making and further assessments. Some parameters showed evidence of unsustainable fishing. For example, estimates of Lm50 for four of the assessed stocks belonging to two species (Nile tilapia Oreochromis niloticus and marbled lungfish Protopterus aethiopicus) were lower than baseline estimates in the studied waterbodies. Furthermore, the Lmean in catches for all the stocks were less than the optimum lengths (Lopt), which maximize catches with a minimal impact on biomass and size structure. No significant changes in Lmean, length–frequency distributions, and size at maturity could be attributed to the management changes implemented in 2018, probably because it is too early to observe changes in these parameters. However, there are positive signs attributable to the changes in management as shown by a high proportion of mature individuals in commercial catches for most of the stocks for which the proportion was calculated, and an increase in Lmean and Lmax for some stocks, such as B. docmak, in commercial or experimental catches. New estimates from this study will enhance decision‐making and further assessments of fisheries. Routine monitoring is recommended to update and improve the estimates.
Modeling Mass Transfer Kinetics and Thermodynamic Properties of Ultrasonically Pretreated and Untreated Apple Slices During Air‐Frying
Authors: Fikry Mohammad , Tagrida Mohamed , Mousa Esraa , Khojah Ebtihal , Aljumayi Huda , Al‐Ghamdi Saleh , Kadota Kazunori , Sarifudin Achmat 
Published: October 2024

ABSTRACTThe combination of pretreatment with ultrasonic technology and air‐frying could improve the quality and efficiency of apple slice processing. This research aimed to explore how ultrasonic treatment prior to frying and varying temperatures during air‐frying impact the drying and thermodynamic characteristics of apple slices. The study also aimed to assess mathematical models that explain the moisture transfer kinetics and to numerically simulate the moisture distribution in apple slices during air‐frying operation. The results revealed that the moisture content and water activity (aw) of apple slices consistently decreased with longer frying times, regardless of the temperature. The mathematical models' precision was confirmed through regression analysis, which accurately represented the dynamics of moisture transfer, activation energy (Ea), and Gibbs free energy (ΔG) throughout the frying process. The results of the statistical analysis showed that the two‐term (exponential) model was effective in predicting moisture transfer in apple slices throughout air‐frying process, while the spatial distribution of moisture was successfully illustrated by the diffusion model under different conditions. Additionally, numerical simulations showed that moisture removal is faster at higher frying temperatures, and ultrasonic pretreatment led to a shorter frying time. Ultrasonic pretreatment combined with higher frying temperatures led to reduced differential enthalpy, along with an increased effective moisture diffusivity and Gibbs free energy difference. These findings are essential for improving and optimizing the frying process in food manufacturing.
DrYFiT: An Excel Freeware Tool to Describe Thin Layer Drying of Foods
Authors: Öksüz Hasan Basri , Buzrul Sencer 
Published: October 2024

ABSTRACTWe introduced DrYFiT (drying data fitting tool), a Microsoft Excel freeware tool to be used for modeling thin‐layer drying of foods, which is available at https://drive.google.com/drive/folders/1ouompmNkmdmw1KMTJUnY0t8dJqSJ9iKv?usp=drive_link. There are 12 models in the tool and it can be used without any modeling and programming skills. Time and moisture ratio data can be entered and one of models available (one at a time) can be selected to describe the drying data. Parameter values, standard error of the parameters, p value and a statement that indicates whether the parameter is statistically significant or not (α = 0.05) are reported. Moreover, R2, adjusted R2 and root mean square error values are calculated for each model. Users can instantaneously observe the experimental data and the model fit on the same graph. Residual plot is given next to this graph. It is possible for the users to have the results of all models applied to drying data within a couple of minutes. The results of DrYFiT were compared with some popular software programs used for nonlinear regression and identical values (parameters, standard errors, p values, goodness‐of‐fit statistics) were obtained for 40 datasets.
Generalizing Determinacy under Monetary and Fiscal Policy Switches: The Case of the Zero Lower Bound
Authors: CHO SEONGHOON , MORENO ANTONIO 
Published: October 2024

AbstractIn a fixed‐regime context, it has been established since the work of Leeper (1991) that a determinate and unique equilibrium can be achieved under both monetary dominance (characterized by an active monetary policy and a passive fiscal policy) and fiscal dominance (characterized by an active fiscal policy and a passive monetary policy) regimes yield a determinate unique equilibrium. In this paper, we generalize this well‐established policy‐mix taxonomy to regime‐switching models, and show that switches from monetary dominance to fiscal dominance regimes (and vice versa) render the economy indeterminate for standard parameter values. We apply our results to the important case of the exit from the zero lower bound (ZLB), where monetary policy is inherently passive. Contrary to the fixed‐regime prediction, the economy switching between the ZLB in a fiscally led regime and a monetary dominance regime is robustly indeterminate, making the coordination of agents' beliefs hard for anchoring expected inflation. Finally, we propose a direction toward which the perspective of the fiscal theory of the price level can be made consistent with a unique stable equilibrium.
Central Bank Independence and Inflation in Latin America—Through the Lens of History
Authors: JÁCOME LUIS I. , PIENKNAGURA SAMUEL 
Published: October 2024

AbstractWe study the link between central bank independence and inflation by providing narrative and empirical evidence based on Latin America's historical experience. Using a novel historical data set of central bank independence for 17 Latin American countries, we recount the rocky journey traveled by central banks to achieve independence and price stability. Our empirical analysis finds a strong negative association between central bank independence and inflation over the last 80 years, with improvements in independence resulting in a steady decline in inflation. Results are robust to endogeneity concerns and to using alternative central bank independence indices.
How Do Housing Markets Affect Local Consumer Prices?: Evidence from U.S. Cities
Authors: CHOI CHI‐YOUNG , JO SOOJIN 
Published: October 2024

AbstractWe examine the link between house and consumer prices in 41 U.S. cities using retail price data for various consumer goods. We find that shifts in house prices precede consumer price changes, with varying impacts depending on location and product categories. The nature of housing market shocks matters too; housing supply shocks move consumer prices temporarily through the cost‐push dynamics, while housing demand shocks have enduring effects via wealth and collateral channels. Our findings imply that housing market fluctuations may have greater impacts on local cost of living and consumer welfare than their representation in the Consumer Price Index.
Rapid and local neuroestrogen synthesis supports long‐term potentiation of hippocampal Schaffer collaterals‐cornu ammonis 1 synapse in ovariectomized mice
Authors: Maroteaux Matthieu J. , Noccioli Claire T. , Daniel Jill M. , Schrader Laura A. 
Published: October 2024

AbstractIn aging women, cognitive decline and increased risk of dementia have been associated with the cessation of ovarian hormones production at menopause. In the brain, presence of the key enzyme aromatase required for the synthesis of 17‐β‐estradiol (E2) allows for local production of E2 in absence of functional ovaries. Understanding how aromatase activity is regulated could help alleviate the cognitive symptoms. In female rodents, genetic or pharmacological reduction of aromatase activity over extended periods of time impair memory formation, decreases spine density, and hinders long‐term potentiation (LTP) in the hippocampus. Conversely, increased excitatory neurotransmission resulting in rapid N‐methyl‐d‐aspartic acid (NMDA) receptor activation rapidly promotes neuroestrogen synthesis. This rapid modulation of aromatase activity led us to address the hypothesis that acute neuroestrogens synthesis is necessary for LTP at the Schaffer collateral‐cornu ammonis 1 (CA1) synapse in absence of circulating ovarian estrogens. To test this hypothesis, we did electrophysiological recordings of field excitatory postsynaptic potential (fEPSPs) in hippocampal slices obtained from ovariectomized mice. To assess the impact of neuroestrogens synthesis on LTP, we applied the specific aromatase inhibitor, letrozole, before the induction of LTP with a theta burst stimulation protocol. We found that blocking aromatase activity prevented LTP. Interestingly, exogenous E2 application, while blocking aromatase activity, was not sufficient to recover LTP in our model. Our results indicate the critical importance of rapid, activity‐dependent local neuroestrogens synthesis, independent of circulating hormones for hippocampal synaptic plasticity in female rodents.