bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a UHPLC‐UV method for the determination of a prostate secretory protein 94‐derived synthetic peptide (PCK3145) in human plasma and assessment of its stability in human plasma
Authors: El Mubarak Mohamed A. , Leontari Iliana , Danika Charikleia , Katsila Theodora , Sivolapenko Gregory 
Published: February 2016

AbstractPCK3145 is a synthetic peptide, derived from the Prostate Secreted Protein 94 (PSP94), with promising in vitro and animal in vivo results in prostate cancer. The aim of the present study was to develop and validate a fast and robust ultra‐high‐performance liquid chromatography with ultraviolet detection for the determination of PCK3145 in human plasma which would be suitable for the assessment of PCK3145 stability to proteolytic degradation. Following protein precipitation, chromatographic separation was carried out on an Aeris Peptide C18 column with mobile phase consisting of acetonitrile–water at a flow‐rate of 0.50 mL/min. The calibration curve was linear over the range 0.50–20.00 μg/mL. Intra‐ and inter‐day percentage relative standard deviation and relative error were ≤10%. The limit of detection and the lower limit of quantification were 0.15 and 0.50 μg/mL, respectively. Recovery of PCK3145 from human plasma was ≥96%. The peptide presented high stability in whole blood and in human plasma (>98% intact peptide after 24 h incubation at 37°C in human plasma), which represents a distinctive advantage in the therapeutic use of the compound. This is the first validated UHPLC method for the determination of PCK3145 reported, and it was successfully applied in the study of the proteolytic stability of PCK3145 in human plasma ex vivo. Copyright © 2016 John Wiley & Sons, Ltd.
Pro‐oxidant and Antioxidant Effects in Photodynamic Therapy: Cells Recognise that Not All Exogenous ROS Are Alike
Authors: Soares Helder T. , Campos Joana R. S. , Gomes‐da‐Silva Lígia C. , Schaberle Fábio A. , Dabrowski Janusz M. , Arnaut Luis G. 
Published: February 2016

AbstractPhotodynamic therapy (PDT) uses light, photosensitizer molecules and oxygen to generate reactive oxygen species (ROS) that kill cancer cells. Redaporfin, a new photosensitizer in clinical trials, generates both singlet oxygen and superoxide ions. We report the potentiation of redaporfin–PDT in combination with ascorbate and with the inhibition of antioxidant enzymes in A549 (human lung adenocarcinoma) and CT26 (mouse colon adenocarcinoma) cells. The addition of ascorbate and the inhibition of superoxide dismutase (SOD) strongly increased the phototoxicity of redaporfin towards A549 cells but not towards CT26 cells. The inhibition of catalase and the depletion of the glutathione pool also potentiate redaporfin–PDT towards A549 cells. The lower SOD activity of A549 cells might explain this difference. SOD activity levels may be explored to increase the selectivity and efficacy of PDT with photosensitizers that generate radical species.
Impact of left ventricular function on clinical outcomes of functional mitral regurgitation patients undergoing transcatheter mitral valve repair
Authors: Azzalini Lorenzo , Millán Xavier , Khan Razi , Couture Philippe , Ducharme Anique , Basmadjian Arsène , Bonan Raoul , Asgar Anita W. 
Published: February 2016

ObjectivesTo evaluate the impact of baseline left ventricular (LV) function on the clinical outcomes of patients with functional mitral regurgitation (FMR) treated with MitraClip.BackgroundIt is unknown whether patients with significant FMR and severe LV dysfunction benefit from MitraClip.MethodsA cohort of 77 patients with significant FMR undergoing MitraClip procedure between December 2010 and January 2015 was categorized by baseline LV ejection fraction (LVEF) into tertiles: LVEF <27% (n = 27), LVEF 27–37% (n = 25), and LVEF >37% (n = 25). We sought to evaluate the impact of LVEF on all‐cause mortality at follow‐up.ResultsThere were no significant differences in baseline comorbidities, medical treatment and MR severity among tertiles of LVEF. Overall procedural success was 94%, with no differences among groups (LVEF <27%: 89%; LVEF 27–37%: 100%; LVEF >37%: 92%; P = 0.25). Median follow‐up was 372 days (interquartile range: 128–627 days). MR severity improved in all three groups, as compared to baseline. There were no differences in the prevalence of MR ≤2+ on follow‐up (P = 0.40). Mortality was highest in patients with LVEF <27% (41%), as compared with LVEF 27–37% (16%) and LVEF >37% (4%), P = 0.004. Patient who died had a lower baseline LVEF compared to those who survived (24.8 ± 7.7% versus 35.5 ± 13.7%, P < 0.001). An LVEF <27% was an independent predictor of mortality after adjusting for procedural success: hazard ratio 3.4 (95% CI: 1.1 to 10.0; P = 0.030).ConclusionsMitraClip is effective in FMR patients regardless of the severity of LV dysfunction. However, low baseline LVEF is associated with increased mortality, despite procedural success. © 2016 Wiley Periodicals, Inc.
Experimental and Numerical Simulation of Dry Pressure Drop in High‐Capacity Structured Packings
Authors: Amini Younes , Karimi‐Sabet Javad , Esfahany Mohsen Nasr 
Published: February 2016

AbstractExperimental and numerical studies were conducted on the performance and capacity of structured packings for mixture separation with very low separation factor. Different formations and conditions of the innovative structured packing PACK‐2100 with high surface area were studied to evaluate the main characteristics such as dry pressure drop. In addition, numerical simulation was performed to describe the details of the flow structure in these modified structured packings. Three‐dimensional computational fluid dynamics modeling of PACK‐2100 allowed for comparing the pressure drop in both laminar and turbulent flow regime. The obtained experimental and numerical data demonstrate the potential contribution of the packing to high‐efficiency systems with low separation factor.
Requirements for Designing a Freeze Casting Process for Drugs – Rheological Properties of Suspensions
Authors: Nguyen Thi Nhat Phuong , Ulrich Joachim 
Published: February 2016

AbstractFreeze casting is a useful molding technique for the production of porous, fast dissolving tablets of foods and pharmaceuticals. In order to optimize the freeze casting process, the slurries, and also the characteristics of the freeze‐casted products, multifunctional additives are usually employed. For further applications of these procedures in industrial processes, the suspension characteristics should be known. This case study focuses on the rheological properties of paracetamol suspensions. The effects of modified starch as an additive, the solid loadings, and the temperature on the flow behavior and viscosities of the suspensions were investigated. It was found that most suspensions are thixotropic systems. The viscosity of the suspensions is highly sensitive with respect to the studied factors, such as shear rate, shearing time, temperature, solid loading, and additive content. Optimized conditions were found and are recommended for industrial use.
In Situ Generation of ArCu from CuF2 Makes Coupling of Bulky Aryl Silanes Feasible and Highly Efficient
Authors: delPozo Juan , Casares Juan A. , Espinet Pablo 
Published: February 2016

AbstractA bimetallic system of Pd/CuF2, catalytic in Pd and stoichiometric in Cu, is very efficient and selective for the coupling of fairly hindered aryl silanes with aryl, anisyl, phenylaldehyde, p‐cyanophenyl, p‐nitrophenyl, or pyridyl iodides of conventional size. The reaction involves the activation of the silane by CuII, followed by disproportionation and transmetalation from the CuI(aryl) to PdII, upon which coupling takes place. CuIII formed during disproportionation is reduced to CuI(aryl) by excess aryl silane, so that the CuF2 system is fully converted into CuI(aryl) and used in the coupling. Moreover, no extra source of fluoride is needed. Interesting size selectivity towards coupling is found in competitive reactions of hindered aryl silanes. Easily accessible [PdCl2(IDM)(AsPh3)] (IDM = 1,3‐dimethylimidazol‐2‐ylidene) is by far the best catalyst, and the isolated products are essentially free from As or Pd (<1 ppm). The mechanistic aspects of the process have been experimentally examined and discussed.
NNP‐Type Pincer Imidazolylphosphine Ruthenium Complexes: Efficient Base‐Free Hydrogenation of Aromatic and Aliphatic Nitriles under Mild Conditions
Authors: Adam Rosa , Alberico Elisabetta , Baumann Wolfgang , Drexler Hans‐Joachim , Jackstell Ralf , Junge Henrik , Beller Matthias 
Published: February 2016

AbstractA series of seven novel NImNHP‐type pincer imidazolylphosphine ruthenium complexes has been synthesized and fully characterized. The use of hydrogenation of benzonitrile as a benchmark test identified [RuHCl(CO)(NImNHPtBu)] as the most active catalyst. With its stable Ru−BH4 analogue, in which chloride is replaced by BH4, a broad range of (hetero)aromatic and aliphatic nitriles, including industrially interesting adiponitrile, has been hydrogenated under mild and base‐free conditions.
Alkoxyallene‐ynes: Selective Preparation of Bicyclo[5.3.0] Ring Systems Including a δ‐Alkoxy Cyclopentadienone
Authors: Tap Aurélien , Lecourt Camille , Dhambri Sabrina , Arnould Mathieu , Galvani Gilles , Nguyen Van Buu Olivier , Jouanneau Morgan , Férézou Jean‐Pierre , Ardisson Janick , Lannou Marie‐Isabelle , Sorin Geoffroy 
Published: February 2016

AbstractThe development of an intramolecular rhodium(I)‐catalyzed Pauson–Khand reaction of alkoxyallene‐ynes with a proximal alkoxy group is reported. This reaction, in the presence of a [Rh(cycloocta‐1,5‐diene)Cl]2/propane‐1,3‐diylbis(diphenylphosphane) system under a CO atmosphere, constitutes a powerful tool for selectively accessing carbo‐ and heterobicyclo[5.3.0] frameworks featuring an enol ether moiety. Through this procedure, a straightforward access to guaiane skeletons with a tertiary hydroxy group at the C10 position was achieved.
Cerium‐Complex‐Catalyzed Oxidation of Arylmethanols under Atmospheric Pressure of Dioxygen and Its Mechanism through a Side‐On μ‐Peroxo Dicerium(IV) Complex
Authors: Paul Mitali , Shirase Satoru , Morimoto Yuma , Mathey Laurent , Murugesapandian Balasubramanian , Tanaka Shinji , Itoh Shinobu , Tsurugi Hayato , Mashima Kazushi 
Published: February 2016

AbstractInvited for the cover of this issue is the group of Hayato Tsurugi and Kazushi Mashima at the University of Osaka. The image depicts a cerium complex with a dianionic pentadentate ligand acting as a catalyst for aerobic oxidation of arylmethanols, in which a dinuclear cerium(IV) side‐on peroxo complex is the key intermediate. The corresponding trivalent complex was able to activate dioxygen, and the oxidation proceeded catalytically under atmospheric pressure with inexpensive and environmentally friendly dioxygen as the primary oxidant. Read the full text of the article at 10.1002/chem.201503846.
A Variety of Phase‐Transition Behaviors in a Niccolite Series of [NH3(CH2)4NH3][M(HCOO)3]2
Authors: Shang Ran , Chen Sa , Hu Ke‐Li , Wang Bing‐Wu , Wang Zhe‐Ming , Gao Song 
Published: February 2016

AbstractA niccolite series of [bnH22+][M(HCOO)3]2 (bnH22+=1,4‐butyldiammonium) shows four kinds of metal‐dependent phase transitions, from high temperature para‐electric phases to low‐temperature ferro‐, antiferro‐, glass‐like, and para‐electric phases. The conformational flexibility of bnH22+ and the different size, mass, and bonding character of the metal ion lead to various disorder‐order transitions of bnH22+ in the lattice and relevant framework modulations, thus different phase transitions and dielectric responses. The magnetic members display a coexistence or combination of electric and magnetic orderings in the low‐temperature region.
ChemInform Abstract: Alkaline Earth‐Gold‐Aluminides: Synthesis and Structure of SrAu3Al2, SrAu2.83Al2.17, BaAu2.89Al2.11 and BaAu7.09Al5.91.
Authors: Gerke Birgit , Poettgen Rainer 
Published: February 2016

AbstractThe title intermetallics are prepared by arc melting of the elements and subsequent annealing (Ta and quartz tubes for Sr and Ba compounds, resp., 825 K, 9 h).
ChemInform Abstract: Single Crystal Structure Determination and Refinement of AgZrCu4 and Ag‐Containing Cu10Zr7 by Precession Electron Diffraction and Tomography Techniques.
Authors: Cora I. , Pekker P. , Dodony I. , Janovszky D. 
Published: February 2016

AbstractThe single crystal structures of the title phases are determined by TEM using the precession electron diffraction technique and diffraction tomography.
ChemInform Abstract: A Novel NIR Long Phosphorescent Phosphor:SrSnO3:Bi2+.
Authors: Qin Xixi , Li Yang , Wu Dakun , Wu Yiling , Chen Ruchun , Ma Zhijun , Liu Shijian , Qiu Jianrong 
Published: February 2016

AbstractSrSnO3:Bi2+ is prepared by a two‐step calcination of stoichiometric amounts of Bi2O3, SnO2, and SrCO3 in air (1.
ChemInform Abstract: Synthesis, Crystal Structure, and NLO Property of the Chiral Sulfide Sm4InSbS9.
Authors: Zhao Hua‐Jun 
Published: February 2016

AbstractThe title compound is prepared by solid state reaction of a stoichiometric mixture of the elements (evacuated silica tubes, 950 °C, 4 d; cooling to 200 °C at a rate of 2.5 K/h).
ChemInform Abstract: Hydrothermal Syntheses, Crystal Structures and Characterization of Two New 1‐D and 2‐D Inorganic—Organic Hybrid Polyoxomolybdates [H2dap]2 [x‐Mo8O26]·2H2O and [Cu(dap)2]2[β‐Mo8O26].
Authors: Wang Xiuhua , Han Qing , Chen Lijuan , Zhao Junwei 
Published: February 2016

AbstractThe new compounds (III) and (V) are hydrothermally synthesized and characterized by single crystal XRD, IR and UV/VIS spectroscopy, and by electrochemical measurements.
ChemInform Abstract: A New Metastable Phase in Fe—Nb—B System.
Authors: Sviridova T. A. , Chueva T. R. , Gorshenkov M. V. , Shelekhov E. V. , Dyakonova N. P. , Borisova P. A. 
Published: February 2016

AbstractThe new metastable phase Nb5Fe33B10 is obtained during crystallization of amorphous Nb10Fe70B20 melt‐spun ribbons (annealing at 800 °C, 1 h).
ChemInform Abstract: Ternary Aurides RE4Mg3Au10 (RE: La, Ce, Pr) and RE4Cd3Au10 (RE: Y, La—Nd, Sm, Gd—Dy) — Ordering Variants of the Zr7Ni10 Type.
Authors: Johnscher Michael , Block Theresa , Niehaus Oliver , Poettgen Rainer 
Published: February 2016

AbstractLn14Mg3Au10 (Ln1: La, Ce, Pr) and Ln24Cd3Au10 (Ln2: Y, La—Nd, Sm, Gd—Dy) are prepared by induction melting of the elements (Nb tubes, 1.
ChemInform Abstract: Synthesis of Cyclic Alkenyl Triflates by a Cationic Cyclization Reaction and Its Application in Biomimetic Polycyclizations and Synthesis of Terpenes.
Authors: Alonso Pedro , Pardo Pilar , Galvan Alicia , Fananas Francisco J. , Rodriguez Felix 
Published: February 2016

AbstractA novel and very simple method for the acid‐mediated cationic cyclization reaction of a range of enyne derivatives or alkynols is developed providing access to a variety of the title triflates without the need of any metallic reagent or catalyst.
ChemInform Abstract: Ring Opening of cis‐3‐Substituted‐2‐Vinylaziridines with Amines.
Authors: Kang On‐Yu , Kang Han‐Young 
Published: February 2016

AbstractLewis acid BF3·OEt2 is required as catalyst for the efficient ring‐opening reactions of activated (Ia) and nonactivated aziridines (Id) with aliphatic and aromatic amines in all cases, except for those of activated aziridines with aliphatic amines (IVa,b).
ChemInform Abstract: A Novel Allyl Transfer Coupled with a Grob Fragmentation.
Authors: Li Shao‐Gang , Chen Hui‐Jun , Yang Yang‐Yang , Wu Wen‐Ju , Wu Yikang 
Published: February 2016

AbstractThe attempt to remove the Tbs protecting group in antibiotic precursors of type (I) leads to formation of an unexpected aldehyde of type (II).
ChemInform Abstract: Bio‐Based Green Solvent for the Catalyst Free Oxidation of Arylboronic Acids into Phenols.
Authors: Gupta Surabhi , Chaudhary Priyanka , Seva Lavudi , Sabiah Shahulhameed , Kandasamy Jeyakumar 
Published: February 2016

AbstractLactic acid is found to be an appropriate reaction medium for the efficient, catalyst‐free oxidation of boronic acids to corresponding phenols or alcohols.
ChemInform Abstract: Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources.
Authors: Aikawa Kohsuke , Toya Wataru , Nakamura Yuzo , Mikami Koichi 
Published: February 2016

AbstractConditions for the application of the (trifluoromethyl)zinc reagent as CF3‐‐anion source for the trifluoromethylation of carbonyl compounds, namely aldehydes and ketones, in order to obtain secondary or tertiary trifluoromethyl substituted alcohols are elaborated.
ChemInform Abstract: Benefits of a Dual Chemical and Physical Activation: Direct Aza‐Michael Addition of Anilines Promoted by Solvent Effect under High Pressure.
Authors: Fedotova Alena , Crousse Benoit , Chataigner Isabelle , Maddaluno Jacques , Rulev Alexander Yu. , Legros Julien 
Published: February 2016

AbstractThe combination of hexafluoroisopropanol as solvent and high‐pressure conditions enables the unprecedented 1,4‐addition of poor nucleophiles like aromatic amines onto sluggish Michael acceptors without a promoter or work‐up.
ChemInform Abstract: Contemporaneous Dual Catalysis: Aldol Products from Non‐Carbonyl Substrates.
Authors: Trost Barry M. , Tracy Jacob S. 
Published: February 2016

AbstractVanadium‐catalyzed 1,3‐transposition of allenols is coupled with a lanthanum‐catalyzed Meinwald rearrangement of epoxides in situ to form aldol products chemo‐, regio‐, and stereoselectively.
ChemInform Abstract: Selectively Fluorinated Cyclohexane Building Blocks: Derivatives of Carbonylated All‐cis‐3‐phenyl‐1,2,4,5‐tetrafluorocyclohexane.
Authors: Ayoup Mohammed Salah , Cordes David B , Slawin Alexandra M Z , O'Hagan David 
Published: February 2016

AbstractCarbonylation/carboxylation reactions of the para‐ and ortho‐iodo derivatives of the title building blocks afford the corresponding benzoic acids and benzaldehydes as building blocks for further derivatization.
ChemInform Abstract: Spontaneous Dimerization of Allenes in situ: An Efficient Synthesis of Substituted 1,2‐Dimethylenecyclobutanes with High Regio‐ and Stereoselectivities.
Authors: Miao Maozhong , Wang Wenmin , Yang Weijun , Xu Lijun , Ma Jing , Ren Hongjun 
Published: February 2016

AbstractStarting from commercially available materials aryl acetylenes, formamides, and TmsCN allenes are generated which dimerize in situ to provide cyclobutanes (IV) with high regio‐ and stereoselectivity.
ChemInform Abstract: Transfer Hydrogenation of Nitroarenes into Anilines by Palladium Nanoparticles via Dehydrogenation of Dimethylamine Borane Complex.
Authors: Patil Nilesh M. , Bhosale Manohar A. , Bhanage Bhalchandra M. 
Published: February 2016

AbstractVarious nitroarenes are converted into the corresponding amines within short reaction times using an environmentally benign borane complex as reducing agent and palladium nanoparticles as a versatile and reusable heterogeneous catalyst.
ChemInform Abstract: ortho C—H Acylation of Aryl Iodides by Palladium/Norbornene Catalysis.
Authors: Dong Zhe , Wang Jianchun , Ren Zhi , Dong Guangbin 
Published: February 2016

AbstractThis Catellani‐type C—H arylation is enabled by isopropyl carbonate anhydrides (II) and (IV), which serve as both an acyl cation and a hydride source.
ChemInform Abstract: The Direct Synthesis of Symmetrical Disulfides and Diselenides by Metal—Organic Framework MOF‐199 as an Efficient Heterogenous Catalyst.
Authors: Soleiman‐Beigi Mohammad , Yavari Issa , Sadeghizadeh Fatemeh 
Published: February 2016

AbstractTitle compounds are efficiently synthesized through a one‐pot protocol from corresponding aryl halides and elemental sulfur or selenium, resp., using a highly crystalline porous copper‐based metal‐organic framework as catalyst.
ChemInform Abstract: Palladium‐Catalyzed Zinc‐Amide‐Mediated C—H Arylation of Fluoroarenes and Heteroarenes with Aryl Sulfides.
Authors: Otsuka Shinya , Yorimitsu Hideki , Osuka Atsuhiro 
Published: February 2016

AbstractThe reaction has a broad substrate scope and tolerates multiple functional groups such as tosyloxy, trimethylsilyl, and pinacolatoboryl groups.
ChemInform Abstract: Fabrication of Palladium Nanoparticles/Graphene/SBA‐15 Nanocomposites for the Catalysis of Suzuki Coupling Reaction.
Authors: Shang Ning‐Zhao , Gao Shu‐Tao , Feng Cheng , Wang Chun , Wang Zhi 
Published: February 2016

AbstractA Pd‐graphene‐SBA‐15 catalyst is found to be highly efficient in Suzuki coupling reactions.
ChemInform Abstract: Zn‐Catalyzed Diastereo‐ and Enantioselective Cascade Reaction of 3‐Isothiocyanato Oxindoles and 3‐Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles.
Authors: Zhao Jian‐Qiang , Wu Zhi‐Jun , Zhou Ming‐Qiang , Xu Xiao‐Ying , Zhang Xiao‐Mei , Yuan Wei‐Cheng 
Published: February 2016

AbstractThe method proves superior to previously developed protocols, thus providing variously substituted polycyclic spirooxindoles in virtually quantitative yields with excellent diastereo‐ and enantioselectivities.
ChemInform Abstract: Asymmetric Synthesis of Spiro[chroman‐3,3′‐pyrazol] Scaffolds with an All‐Carbon Quaternary Stereocenter via a Oxa‐Michael—Michael Cascade Strategy with Bifunctional Amine‐Thiourea Organocatalysts.
Authors: Zheng Weiping , Zhang Jiayong , Liu Shuang , Yu Chengbin , Miao Zhiwei 
Published: February 2016

AbstractIt is shown that the thiourea moiety and cyclohexyl scaffold of the employed bifunctional catalyst play a significant role in controlling the stereoselectivity of the oxa‐Michael‐Michael cascade reaction.
ChemInform Abstract: Synthesis of Naphthofurans by tBuOK‐Catalyzed Intramolecular Anionic Cycloaddition of Unsymmetrical Bis‐propargyl Ethers.
Authors: Grimaldi Tamiris B. , Back Davi F. , Zeni Gilson 
Published: February 2016

AbstractOptimized conditions allow the preparation of the desired heterocyclic skeleton within a short time.
ChemInform Abstract: Metal‐Free Coupling of 2‐Vinylphenols and Carboxylic Acids: An Access to 3‐Acyloxy‐2,3‐dihydrobenzofurans.
Authors: Chen Jijun , Shao Ying , Zheng Hao , Cheng Jiang , Wan Xiaobing 
Published: February 2016

AbstractThe new coupling reaction between 2‐vinylphenols and carboxylic acids results in the formation of dihydrobenzofuran derivatives using Bu4NI as a catalyst and t‐BuOOH as an oxidant.
ChemInform Abstract: Asymmetric Construction of 3,4‐Diamino Pyrrolidines via Chiral N,O‐Ligand/Cu(I) Catalyzed 1,3‐Dipolar Cycloaddition of Azomethine Ylides with β‐Phthalimidonitroethene.
Authors: He Fu‐Sheng , Zhu Han , Wang Zheng , Gao Ming , Yu Xingxin , Deng Wei‐Ping 
Published: February 2016

AbstractThe scalable preparation of the title products is based on the diastereoselective and enantioselective synthesis of N‐phthalimide‐protected 5‐aryl or 5‐alkyl substituted 3‐amino‐4‐nitropyrrolidine‐2‐carboxylates.
ChemInform Abstract: Bifunctional Phase‐Transfer Catalysis in the Asymmetric Synthesis of Biologically Active Isoindolinones.
Authors: Di Mola Antonia , Tiffner Maximilian , Scorzelli Francesco , Palombi Laura , Filosa Rosanna , De Caprariis Paolo , Waser Mario , Massa Antonio 
Published: February 2016

AbstractA series of 23 bifunctional chiral ammonium salts is tested as catalysts in the asymmetric cascade reaction of 2‐cyanobenzaldehyde with dimethyl malonate.
ChemInform Abstract: One‐Pot Synthesis of 3‐Iminoisoindolinones by a Rhodium(III)‐Catalyzed and Methanol‐Assisted C—H Cyanation‐Cyclization Cascade with N‐Alkoxyl Transfer.
Authors: Jia Jinlong , Liu Xuelei , Shi Jingjing , Xu H. Eric , Yi Wei 
Published: February 2016

AbstractThe title compounds, key structures in the preparation of various heterocyclic systems including natural products and pharmaceutical agents, are readily available on treatment of N‐alkoxybenzamides with cyano‐reactant (II).
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Addition of C—N Bond to Alkynes: A Novel Approach to 3‐Diketoindoles.
Authors: Wu Chenglin , Zhao Fei , Shu Shuangjie , Wang Jiang , Liu Hong 
Published: February 2016

AbstractThe title indoles are obtained by indole ring construction with the migration of the α‐ketoacyl group.The protocol features operational simplicity, high atom economy, broad substrate scope, and high yields.