bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of adrenaline and metabolic stress on exercise‐induced intracellular signaling and PGC‐1α mRNA response in human skeletal muscle
Authors: Brandt Nina , Gunnarsson Thomas P. , Hostrup Morten , Tybirk Jonas , Nybo Lars , Pilegaard Henriette , Bangsbo Jens 
Published: July 2016

AbstractThis study tested the hypothesis that elevated plasma adrenaline or metabolic stress enhances exercise‐induced PGC‐1α mRNA and intracellular signaling in human muscle. Trained (VO2‐max: 53.8 ± 1.8 mL min−1 kg−1) male subjects completed four different exercise protocols (work load of the legs was matched): C – cycling at 171 ± 6 W for 60 min (control); A – cycling at 171 ± 6 W for 60 min, with addition of intermittent arm exercise (98 ± 4 W). DS – cycling at 171 ± 6 W interspersed by 30 sec sprints (513 ± 19 W) every 10 min (distributed sprints); and CS – cycling at 171 ± 6 W for 40 min followed by 20 min of six 30 sec sprints (clustered sprints). Sprints were followed by 3:24 min:sec at 111 ± 4 W. A biopsy was obtained from m. vastus lateralis at rest and immediately, and 2 and 5 h after exercise. Muscle PGC‐1α mRNA content was elevated (P < 0.05) three‐ to sixfold 2 h after exercise relative to rest in C, A, and DS, with no differences between protocols. AMPK and p38 phosphorylation was higher (P < 0.05) immediately after exercise than at rest in all protocols, and 1.3‐ to 2‐fold higher (P < 0.05) in CS than in the other protocols. CREB phosphorylation was higher (P < 0.05) 2 and 5 h after exercise than at rest in all protocols, and higher (P < 0.05) in DS than CS 2 h after exercise. This suggests that neither plasma adrenaline nor muscle metabolic stress determines the magnitude of PGC‐1α mRNA response in human muscle. Furthermore, higher exercise‐induced changes in AMPK, p38, and CREB phosphorylation are not associated with differences in the PGC‐1α mRNA response.
Molecular genetics related to non-Hodgkin lymphoma
Authors: Guo Ming , Mao Xianglin , Ding Xiaoqing 
Published: July 2016

AbstractNon-Hodgkin lymphoma (NHL) is a serious disease, with a high proportion of mortality. Molecular genetic abnormalities are very common in NHL, but specific characterization in accordance to molecular genetics for lymphoma subtypes is not yet completed. This article summarizes the relationship between B- and T-NHL and molecular genetics. We focus on NHL subtypes and emphasize its features to figure out what is exposed about NHL genetics. The basis of this method is collection of biological specimens for genomic and genetic analyses. This summary may help to prompt prediction of outcomes and guide therapy in the future.
Plant defense responses against viral and bacterial pathogen infections. Focus on RNA-binding proteins (RBPs)
Authors: Oskar Musidlak , Buchwald Waldemar , Nawrot Robert 
Published: July 2016

Summary
Plants have developed intricate defense mechanisms against pathogen infections. Immune system of medicinal plants is well developed. The molecular mechanisms of their ability to protect themselves are not fully understood. Little is known about RNA-binding proteins (RBPs) present in medicinal plants. However, CmGRP1 is an RBP found in the milky sap of medicinal plant Chelidonium majus L. what implies possible importance of RBPs in plant immunity. In this review recent insights into the role of plant RBPs in antiviral and antibacterial defense responses are discussed.
Media Pembelajaran Geometri Menggunakan Pendekatan Pendidikan Matematika Realistik Berbasis GeoGebra
Authors: Saputro Bagus Ardi , Prayito Muhammad , Nursyahidah Farida 
Published: July 2016

<p align="justify">Tujuan dari penelitian ini adalah untuk mengembangkan media geometri menggunakan pendekatan Pendidikan Matematika Realistik Indonesia (PMRI) berbasis GeoGebra. Metode yang digunakan adalah Research and Development (R&amp;D) dengan model 4D Thiagarajan yang terdiri dari tahap pendefinisian, perancangan, pengembangan, dan diseminasi. Hasil penelitian ini menunjukkan bahwa hasil validasi media dari validator 1 mendapat skor 46 atau dalam nilai sangat baik, dan dari validator 2 mendapat skor 45 atau dalam nilai baik. Sedangkan hasil validasi materi dari kedua validator manyatakan bahwa media yang dikembangkan ini sangat baik dengan skor masing-masing 51 dan 50. Media ini dapat menciptakan proses pembelajaran yang berpusat pada siswa, mengeksplorasi khasanah kearifan lokal yang digunakan sebagai konteks pembelajaran yang memenuhi semua karakteristik PMRI dan berbasis GeoGebra.</p><p align="justify"><em>The aim of this research is to develop geometry media using PMRI approach based on GeoGebra. This research used methodology of research and development (R&amp;D) of four model of Thiagarajan that consist of four step, which are define, design, develop, and disseminate. The result of this research shows that validate of media from the first expert reviewer got score 46 or in other word this media is very good, then score from the second expert reviewer got 45 or in other word this media is good. And the result of validate of material from both expert reviewer is very good by getting score 51 and 50 respectively. The using of this media can create learning process with students center, explore the local wisdom as a context in learning that material that fulfill all of the characteristic of PMRI based on GeoGebra. </em></p>
Perbedaan Hasil Belajar Siswa Dalam Pendekatan Realistik Dengan Pendekatan Ekspositori Pada Mata Pelajaran Matematika Kelas IV SDN 101880 Tanjung Morawa
Authors: Tarigan Daitin , Sinaga Esther M. 
Published: July 2016

<p align="justify">Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar siswa dalam pendekatan realistik dengan pendekatan ekspositori pada mata pelajaran matematika kelas IV SDN 101880 Tanjung Morawa T.A. 2012/2013. Penelitian ini menggunakan metode kuasi eksperimen. Sampel yang diteliti sebanyak 60 siswa yang terdiri dari 25 siswa kelas eksperimen dan 35 siswa kelas kontrol. Instrumen yang di gunakan adalah tes hasil belajar bentuk isian sebanyak 10 soal. Berdasarkan analisis data pada kelas eksperimen diperoleh rata-rata nilai pre test 9,2 dan standar deviasi 12,88, untuk data post test diperoleh rata-rata 52 dan standar deviasi 31,36. Untuk kelas kontrol diperoleh rata-rata nilai pre test 15,14 dan standar deviasi 14,82, untuk data post test diperoleh rata-rata 44,57 dan standar deviasi 25,36. Pengujian hipotesis menggunakan uji-t, didapat t<sub>hitung</sub> = 5,38 &gt; t<sub>tabel </sub>= 1,671, dengan taraf signifikansi α = 0,05. Maka H<sub>0</sub> ditolak sehingga dapat disimpulkan bahwa Terdapat pebedaan hasil belajar matematika siswa pada materi penjumlahan pecahan yang diajarkan dengan pendekatan matematika realistik dan pendekatan ekspositori di kelas IV SD Negeri 101880 Tanjung Morawa tahun ajaran 2012/2013.</p><p align="justify"><em>This study aims to determine differences in student learning outcomes in a realistic approach to the expository approach in mathematics class IV SDN Tanjung Morawa 101 880 TA 2012/2013. This study used a quasi-experimental methods. The samples studied were 60 students consisting of 25 students and 35 students experimental class control class. The instrument used is the achievement test stuffing form of 10 questions. Based on the analysis of data on the experimental class gained an average pre-test score of 9.2 and a standard deviation of 12.88, post test data gained an average of 52 and a standard deviation of 31.36. To control class gained an average pre-test score standard deviation of 15.14 and 14.82, for a post test the data gained an average of 44.57 and a standard deviation of 25.36. Hypothesis testing using t-test, obtained t = 5.38&gt; table = 1,671, with a significance level α = 0.05. Then H0 is rejected so that it can be concluded that the learning outcomes are pebedaan mathematics student at the sum of material fractions being taught with realistic mathematics approach and expository approach in the fourth grade elementary school Tanjung Morawa 101 880 2012/2013 academic year.</em></p><p> </p>
Emergency Information Forms for Children With Medical Complexity: A Simulation Study
Authors: Abraham George , Fehr James , Ahmad Fahd , Jeffe Donna B. , Copper Tara , Yu Feliciano , White Andrew J. , Auerbach Marc , Schnadower David 
Published: July 2016

BACKGROUND:
Emergency information forms (EIFs) have been proposed to provide critical information for optimal care of children with medical complexity (CMC) during emergencies; however, their impact has not been studied. The objective of this study was to measure the impact and utility of EIFs in simulated scenarios of CMC during medical emergencies.

METHODS:
Twenty-four providers (12 junior, 12 experienced) performed 4 simulations of CMC, where access to an EIF was block randomized by group. Scenario-specific critical action checklists and consequential pathways were developed by content experts in simulation and pediatric subspecialists. Scenarios ended when all critical actions were completed or after 10 minutes, whichever came first. Two reviewers independently evaluated the video-recorded performances and calculated scenario-specific critical action scores. Performance in scenarios with and without an EIF was compared with Pearson’s χ2 and Mann–Whitney U tests. Interrater reliability was assessed with intraclass correlation. Each provider rated the utility of EIFs via exit questionnaires.

RESULTS:
The median critical action score in scenarios with EIFs was 84.2% (95% confidence interval [CI], 71.7%–94.1%) versus 12.5% (95% CI, 10.5%–35.3%) in scenarios without an EIF (P &lt; .001); time to completion of scenarios was shorter (6.9 minutes [interquartile range 5.8–10 minutes] vs 10 minutes), and complication rates were lower (30% [95% CI, 17.4%–46.3%] vs 100% [95% CI, 92.2%–100%]) with EIFs, independent of provider experience. Interrater reliability was excellent (intraclass correlation = 0.979). All providers strongly agreed that EIFs can improve clinical outcomes for CMC.

CONCLUSIONS:
Using simulated scenarios of CMC, providers’ performance was superior with an EIF. Clinicians evaluated the utility of EIFs very highly.
Elaboração e avaliação sensorial de linguiças toscanas de carne caprina com adição de farinha de aveia
Authors: Lima C. V. , Alves V. R. , Costa Z. R. T. , Sousa A. B. B. , Soares D. J. 
Published: July 2016

<p>Em decorrência da falta de tempo para alimentar-se corretamente, as pessoas passaram a consumir, com maior frequência, produtos industrializados, frituras, guloseimas e sanduíches, desconsiderando os fatores negativos à saúde. Visando a necessidade de elaboração de alimentos com baixos teores de colesterol, o presente trabalho teve como objetivo elaborar e estudar a aceitação sensorial de linguiças toscanas de carne caprina enriquecidas com aveia. Foram produzidas duas formulações de linguiça de carne caprina, onde a única diferença entre as duas formulações foi a presença/ausência da aveia. Realizou-se o teste de aceitação sensorial e atitude de compra das linguiças com 50 provadores não treinados. As notas atribuídas pelos provadores para os atributos cor, sabor, textura e aceitação global foram entre 7 (Gostei Moderadamente) e 8 (Gostei Muito), indicando que ambas as formulações encontram-se dentro da zona de aceitação. As notas atribuídas pelos provadores para a atitude de compra correspondem a “Provavelmente compraria”, mostrando que este produto pode ser comercializado.</p><p> </p><p align="center"><strong><em>Preparation and evaluation of Tuscan sausage of goat meat with the addition of oatmeal</em></strong></p><p align="center"><em> </em></p><p>Abstract -Due to the lack of time to eat properly, people started to consume more frequently, manufactured products, fried foods, sweets and sandwiches, disregarding the negative factors to health. Aiming at the need to prepare food with low cholesterol levels, this study aimed to prepare and study the sensory acceptance ofTuscan sausage of goat meat with the addition of oatmeal. Two goat meat sausage formulations, where the only difference between of the two formulations was the presence/absence of oatmeal, were produced. A sensory acceptance test was carried out with 50 untrained panelists. The marks awarded by the panelists for the color, flavor, texture and overall acceptance attributes were between 7 (Moderately Good) and 8 (Very Good), indicating that both formulations are within the zone of acceptance. The marks awarded by the judges for the purchase of attitude corresponds to "Probably Buy", showing that this product can be marketed.</p><p> </p>
Associations between Culturally Relevant Recruitment Strategies and Participant Interest, Enrollment and Generalizability in a Weight-loss Intervention for African American Families
Authors: Huffman Lauren E. , Wilson Dawn K. , Kitzman-Ulrich Heather , Lyerly Jordan E. , Gause Haylee M. , Resnicow Ken 
Published: July 2016

<p><strong>Objective: </strong>Culturally relevant recruitment strategies may be an important approach for recruiting ethnic minorities for interventions. Previous research has examined associations between recruitment strategies and enrollment of African Americans (AA), but has not explored more deeply the role of incorporating sociocultural values into recruitment strategies. Our current study explores whether sociocultural recruitment mediums were associated with demographics, interest and enrollment in a weight-loss intervention. </p><p><strong>Method: </strong>Sociocultural mediums included community partnerships, culturally relevant ads, sociocultural events, or word-of-mouth. Non-sociocultural mediums included community/ school events that did not specifically target AAs. Analyses examined whether demographics of enrolled families differed by recruitment strategy and if recruitment strategy predicted scheduling a baseline visit, enrolling in a run-in phase, and enrolling in the intervention program. <strong></strong></p><p><strong>Results: </strong>Families recruited from culturally relevant ads, sociocultural events, or word-of- mouth were 1.96 times more likely to schedule a baseline visit (OR=1.96, 95% CI=1.05, 3.68) than families recruited from non-sociocultural mediums. No differences were found for sociocultural mediums on enrolling in the run-in phase or the intervention. However, among enrolled families, those recruited from sociocultural mediums were less likely to be employed (X2 [1, N=142] =5.53, P&lt;.05) and more likely to have lower income (X2 [1, N=142] =13.57, P&lt;.05). </p><p><strong>Conclusion: </strong>Sociocultural mediums were associated with scheduling a baseline visit, but not enrollment. They were, however, effective in recruiting a more generalizable sample among enrolled participants based on demographic characteristics. Integrating sociocultural values into recruitment methods may be a valuable strategy for increasing interest in participation among underrepresented AA families. <em>Ethn Dis. </em>2016;26(3):295-304; doi:10.18865/ed.26.3.295 </p>
Our Three Children
Authors: Dolan Tim 
Published: July 2016

ABSTRACTIn this column, a father shares fond memories of the births of his three children in the 1970s. His story highlights the importance of knowledge and a willingness to speak up to have a positive birth experience. Although the births—an unexpected cesarean, a vaginal birth after cesarean, and a home birth—took place decades ago, the choices this couple faced and the challenges they experienced are not too different from today.
Development of a specialty medication prior-authorization service at an urban academic medical center
Authors: Martin Michelle T. , Telebak Elena , Taylor Paige A. , Volozhina Olga 
Published: July 2016

Abstract

Purpose
The project in which a clinical pharmacist enlisted the help of pharmacy students to create a team responsible for prior-authorization (PA) paperwork associated with hepatitis C virus (HCV) infection treatment is described.

Summary
Many insurance companies require completion of a time-consuming PA process for approval of high-cost specialty medications, such as those used in the treatment of HCV infection. A clinical pharmacist at an urban academic medical center recruited pharmacy students to assist with and streamline the HCV medication PA process. After training, the students developed a protocol to increase the efficiency of completing PA requests, appealing denials, obtaining PA extensions, and documenting progress in the electronic medical record to ensure continuity of care. The PA team collaborated with clinicians to document proof of medical need and worked with insurers, pharmacies, and patients to achieve timely approval and receipt of medications. From June 2014 to March 2015, three students spent 240 hours developing the PA protocol and completing 88 PA requests, with an overall medication approval rate of 87.7%; 18 patients were also referred to medication assistance programs. The PA team’s work allowed the clinical pharmacist to spend more time on clinical activities and scholarship, while the students increased their knowledge of HCV disease and HCV-targeted therapies and improved their skills in written and verbal communication with patients, providers, and insurance companies.

Conclusion
Pharmacy students successfully implemented a PA team to manage prescription approval for HCV medications with assistance from a clinical pharmacist.
Training of students-philologists comic genres of professional speech
Authors: Surkova Anastasiya Pavlovna 
Published: July 2016

In clause the model of training of the students – philologists to creation and use of speech comic genres (in particular, such, as the comic story, anecdote, historical anecdote, joke, comic aphorism and winged words)) in the pedagogical purposes is considered (examined). It will promote, on our sight, optimization of professional dialogue of the teacher in an educational situation.
Manuais escolares de Ciências Naturais de 8º ano em Portugal e estrutura conceptual do PISA 2006
Authors: Antunes Maria P. Lobo , Galvão Cecília 
Published: July 2016

Este artigo incide na análise das atividades de aprendizagem e avaliação formativa da unidade curricular "Gestão Sustentável dos Recursos" (GSR) em manuais escolares de Ciências Naturais do 8º ano. Tem o objetivo de verificar qual a sintonia entre o modelo de desenvolvimento de competências proposto nos manuais e o promovido pela avaliação em literacia científica do PISA 2006.Assente numa investigação de caráter qualitativo, o fundamento teórico acorda com a estrutura conceptual do PISA 2006. Os manuais foram selecionados segundo o critério "manual mais adotado num distrito". Os resultados revelaram uma ênfase no desenvolvimento de competências assente na aquisição de conhecimento factual como verificação da capacidade de ler ecompreender o contexto, desligado das ideias e conceitos que complementam as competências. Revelam ainda ausência de situações de aprendizagem que promovam o conhecimento e a compreensão da ciência. Palavras-chave: Currículo; Manuais escolares; Competências; PISA 2006
PENINGKATAN KETERAMPILAN MEMBACA PERMULAAN MELALUI MEDIA FLASHCARD PADA SISWA KELAS I SDN BAJAYAU TENGAH 2
Authors: Rahman Budi , Haryanto Haryanto 
Published: July 2016

<p class="E-JOURNALTitleEnglish">Penelitian ini bertujuan untuk meningkatkan keterampilan membaca siswa kelas I SDN Bajayau Tengah 2 Kecamatan Daha Barat Kabupaten Hulu Sungau Selatan. Penelitian ini merupakan penelitian tindakan kelas yang menggunakan desain model Kemmis &amp; Taggart. Subjek penelitian adalah 18 siswa kelas I SDN Bajayau Tengah 2 tahun pelajaran 2013/2014. Teknik pengumpulan data yang digunakan adalah observasi, tes unjuk kerja. Instrumen yang digunakan adalah lembar pengamatan, soal tes unjuk kerja, dan lembar penilaian membaca. Data yang terkumpul dianalisis dengan teknik deskriptif. Hasil penelitian menunjukkan bahwa media <em>flashcard </em>dapat meningkatkan keterampilan membaca permulaan siswa kelas I SDN Bajayau Tengah 2. Peningkatan keterampilan membaca permulaan dapat dilihat dari nilai rata-rata sebelum diberi tindakan sebesar 59,7%, yang termasuk dalam kategori cukup; kemudian meningkat pada siklus I menjadi 71,3%, yang termasuk dalam kategori baik; kemudian meningkat lagi pada siklus II menjadi 90,7%, yang termasuk dalam kategori baik sekali.</p> <p class="E-JOURNALAbstrakKeywords"><strong>_______________________________________________________________________________________________________________________________________________________________________________________________________</strong></p> <p><strong>IMPROVING EARLY READING SKILL THROUGH FLASHCARD MEDIA IN 1<sup>ST</sup>GRADE STUDENTS OF STATE ELEMENTARY SCHOOL (SDN) BAJAYAU TENGAH 2<br /></strong></p> <p class="E-JOURNALAbstrakTitle"><em><strong>ABSTRACT</strong></em></p> <p class="E-JOURNALAbstractBody"><em>This study aims to improve the early reading skill of 1st grade students of State Elementary School (SDN) Bajayau Tengah 2, Daha Barat District, Hulu Sungai Selatan Regency. This study was classroom action research using Kemmis &amp; Taggart model design. The subject was 18 1st grade students of SDN Bajayau Tengah 2 in 2013/2014. The data collection technique used was observation, performance test. The instrument used was observation sheets, performance test exercises, and reading assessment sheets. The data were analyzed using the descriptive technique. The result shows that flashcard media could improve the early reading skill of 1st grade students of SDN Bajayau Tengah 2. The improvement of the early reading skill could refer to the value evarage before the action was 59.7%, which is a fair category; then it increase to 71.3% in the first cycle, which is in a good category; then it increase to 90.7% in second cycle, which is in an excellent</em> category.</p> <strong>Keywords</strong>: early reading skill, flashcard media<br />