bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the causality and pathogenesis of atrial fibrillation with dilated cardiomyopathy: An integrated multi-omics approach
Authors: Wen Huan , Su Bo , Liu Jinbo , Wang Hongyu 
Published: October 2024

Abstract

Background: Atrial fibrillation (AF) is the most prevalent sustained arrhythmia, and recent evidence indicates the presence of cardiac enlargement in patients with AF. Dilated cardiomyopathy (DCM), the most common form of cardiomyopathy, is characterized by significant heart dilation and AF. However, the risk factors and underlying mechanisms linking DCM to AF remain poorly understood.
Methods: Mendelian randomization (MR) analysis was initially used to explore the potential causal relationship between AF and DCM. Data were sourced from the public database Gene Expression Omnibus (GEO), and differentially expressed genes (DEGs) and significant module genes were identified using the Limma package and weighted gene co-expression network analysis (WGCNA). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, as well as a protein-protein interaction (PPI) network analysis, were performed on the intersected genes. Hub genes were screened using machine learning algorithms. The identification of hub genes within the DCM GSE17800 dataset was achieved using the receiver operating characteristic (ROC) curve and nomogram, which were employed to assess the diagnostic efficacy of these hub genes. Finally, the immune infiltration of DCM and the microRNA (miRNA) interaction network involving hub genes were evaluated.
Results: MR analysis demonstrated that genetic susceptibility to AF was significantly associated with an increased risk of DCM (β: 20.44, 95% CI: 15.00-25.88, p=0.0002). The AF dataset included 1850 DEGs and 572 significant module genes, and the DCM dataset included 6463 DEGs, which had a total of 209 intersected genes with module genes for AF. After correlation enrichment analysis and PPI interaction network on the intersected genes, machine learning was used to screen two hub genes (VSNL1 and ETNPPL) that had high diagnostic efficacy (area under the curve from 0.81 0.89). Immune infiltration analysis of these genes revealed a relatively normal immune status for DCM, with a wider miRNA interaction network for VSNL1.
Conclusion: MR data suggests that genetic changes in the presence of AF are significantly associated with an increased risk of DCM. The two identified hub genes (VSNL1 and ETNPPL) can be used to diagnose comorbid DCM in patients with AF.
Survival Rate Changes in Children With Congenital Diaphragmatic Hernia Over the Past Three Decades: a Nationwide, Population-based Prospective Nested Case-control Study
Authors: Kutasy Balazs , Burgos CM 
Published: October 2024

Abstract

PURPOSE: The survival rate (SR) for neonates born with congenital diaphragmatic hernia (CDH) remains high. Our aim was to investigate how changed the SR in children with CDH over the past decades.
METHODS: The study was a nationwide, population-based prospective nested case-control study within a cohort of newborn children who was born in Sweden during the observational period from 1st January 1982 until 31st December 2015.
RESULTS: In the study period 4654 (99.6%) control children, and 684 children with CDH (70.4%,p<0.001) were survival at 2-years of age. Any patients who were born with CDH has overall 5,8 times higher chance for not survive 2-years of age than children without CDH. The SR improved significantly in CDH in the past 3 decades. Significantly higher number of patients were premature born in the CDH group than in the controls (23.3%vs6.1%,p<0.001). The SR of premature and non-premature born CDH patients increased significantly over the past 3 decades.
CONCLUSION:
The SR of CDH patients were significantly increased in the past 3 decades. Although, the 2-years survival remains 5,8 times higher than those who were not born with CDH. These changes were mainly attributed to the improved SR of premature and non-premature born CDH patients.
Sugammadex related atypical laryngospasm with unusual rescue A case report
Authors: Ren Hongyuan , Liu Yan , Lu Yuechun 
Published: October 2024

Abstract

Purpose To describe our experience using rocuronium to rescue sugammadex related atypical laryngospasm during a case under general anesthesia.
Clinical features A patient was a 56-year-old, who was admitted for fungal keratitis and underwent a Penetrating Keratoplasty (PKP) on 12th June 2024. The procedure was smooth and took about 100 minutes. An airway spasm just happened after 120mg sugammadex was provided at the end of the procedure and manual ventilation did few work. Then 30mg rocuronium was provided for intubation, about 30 seconds later the ventilation became into effect and intubation successfully. We saw half-closed vocal cords during the intubation.
Conclusions Laryngospasm remains a tenacious problem for unpredictable causes and atypical signs, furthermore rocuronium may be an unusual and brilliant choice for the laryngospasm especially when it was related tosugammadex and presented atypically.
IgG4-related disease characterized by recurrent episodes of transient ischemic attacks: A case report and literature review
Authors: Hu Ya-ting , Chu Xu , Wang Yan-li , Kong Qing-xia , Sun Ran , Yan Huan 
Published: October 2024

Abstract

IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that involves multiple organs in the body. The most commonly affected tissues or organs include lymph nodes, submandibular glands, lacrimal glands and the pancreas. However, a minority of cases can involve the central nervous system (CNS), manifesting as hypertrophic pachymeningitis, cerebral vasculitis, cerebellar infarction and other related conditions. The present case report documents a patient with IgG4-RD with recurrent transient ischemic attacks (TIA), aiming to explore the pathogenesis, clinical features, treatment and prognosis of IgG4-RD complicated with TIAs. By analyzing the present case, the aim was to raise clinician awareness of the potential neurological implications caused by IgG4-RD and to explore its possible pathological mechanisms.
Investigating the structural changes in amino acids conformations interacting with a toxic effector molecule within the Hcp1 tail/tube complexes of the type VI secretion system using artificial intelligence and deep learning platform
Authors: Shakibaie Mohammad Reza 
Published: October 2024

Abstract

Background: The primary objective of this study is to understand how a putative toxic effector of the type VI secretion system (T6SS) in Acinetobacter baumannii triggers the contraction of the Hcp1 nanotube through the application of an Artificial Intelligence (AI) and Deep Learning (DL) framework. Furthermore, the virtual assessment of components associated with this secretory system was also investigated.
Methods: The amino acid sequences of T6SS components were retrieved from the GenBank database. AI software such as AlphaFold2, and neural DL software like Rosetta-Fold were used to generate the 3D structures of T6SS protein components. The Rosetta Packer (DLP) program was employed to identify the side chains of the amino acids involved in binding to the effector. A backbone-dependent rotamer library for amino acids side chains was developed based on the Dunbrack rotag package.
Results: Through the machine learning AI system, it has been found that each specific effector molecule binds specifically toa particular set of amino acids (in this case; Lys, Phe, Arg, and His) within the Hcp1 monohexameric ring by H-bound. This interaction induces a rotameric shift in the dihedral angles (Φ/Ψ) of the aforementioned amino acids' side chains launching the contraction of the Hcp1 tail/tube complex and injection effector molecule to the prey cell. Furthermore, TssB/C, TssM, and ClpV ATPase T6SS components are essential for the propulsion of the effector molecule.
Conclusion: This study reveals the mechanism by which the effector molecule induces changes in the conformational of the amino acid side chain from the apo to the hollo state along the Hcp1 tail, resulting in the contraction and propulsion of the substrate into the target cell.
Tonsillitis toxicity for breast cancer radiation therapy and control over this by ARIA Visual Care Path
Authors: Ishkinin Yevgeniy , Nazarbek Serzhan , Zhakhina Gulnur , Datbayev Kairgeldy , Ossikbayeva Saniya , Akhunova Radmila 
Published: October 2024

Abstract

Radiation therapy (RT) is a cornerstone in the treatment of breast cancer, with advances in technology improving both precision and patient outcomes. However, RT can cause various toxicities, traditionally focused on skin, lung, and cardiac complications. Tonsillitis, a less common but emerging complication, may arise due to unintended radiation exposure to nearby structures like the thyroid. This study investigates the occurrence of tonsillitis in breast cancer patients undergoing RT and evaluates the effectiveness of the ARIA Visual Care Path (VCP) in mitigating this complication. A retrospective analysis was conducted on 137 breast cancer patients treated at the Almaty Oncology Center. Patients were divided into two groups: hypofractionated radiation therapy (HFRT, n=68) and standard radiation therapy (SRT, n=69). Tonsillitis was observed in 29.2% of patients, with a higher incidence in the SRT group (33.3%) compared to the HFRT group (25.0%). Tonsillitis development was significantly associated with higher mean thyroid doses (>22 Gy, p=0.009) and lower body mass index (BMI ≤ 25, p=0.001). Following the implementation of the Breast Care Path algorithm, the incidence of tonsillitis was significantly reduced from 29.2% to 4.9% (p=0.0001). Skin reactions were less severe in the HFRT group, and no significant differences were observed in cardiac or lung doses between groups. Tonsillitis toxicity, while not typically a recognized complication of breast cancer RT, was linked to higher thyroid doses and lower BMI. The Breast Care Path algorithm proved effective in reducing tonsillitis rates, highlighting the importance of dosimetric planning and personalized care pathways in improving patient outcomes.
A multiple metastatic colon cancer patient with extra-long survival and acquired BRAF mutation: case report and literature review
Authors: Chen Yan , Kou Zhongyang , He Lulu , Wu Yufei , Lu Yujie , Wang Ying , Guo Pengda , Cai Hongfa , Liu Kaili , Yang Jun , Gu Haidi , Su Jiang , Guo Feng 
Published: October 2024

Abstract

For colorectal cancer patients, metastasis is a major cause of high mortality and short survival. Precision medicine has led to significant advances in targeted therapy and immunotherapy in the treatment of colorectal cancer, providing more options for patients with mCRC and eventually improving their prognosis. However, the use of these drugs is limited by pre-existing intrinsic resistance mechanisms or the ability of cancer cells to acquire resistance. This report presents a colorectal cancer patient who survived 12 years. After the first palliative resection for descending colon cancer, this patient had experienced local recurrence, splenic and diaphragmatic metastases, splenic fossa and incisional implant metastases, renal metastases, and liver metastases. The patient underwent five surgical resection procedures and benefited from surgery combined with chemotherapy. The disease was initially controlled with first-line treatment when the patient developed liver metastases. After the metastases progressed, next-generation sequencing (NGS) revealed the patient's acquired genomic alternation, BRAF V600E. This case highlights the importance of combining local and systemic therapy and the need to be aware of acquired genomic alternations.
Body composition determined with computed tomography at ICU admission as a potential long- term outcome assessment tool in critically ill patients: a post-hoc analysis of a prospective, observational study.
Authors: Deana Cristian , Cereser Lorenzo , Nardone Luigi , Danielis Matteo , Cherchi Vittorio , Biasucci Daniele Guerino , Umbrello Michele , Piani Tommaso , Lucchese Francesca , Vetrugno Luigi 
Published: October 2024

Abstract

Background: body composition evaluated with computed tomography scan (CT) at intensive care unit (ICU) admission is a predictor of short-term mortality (6 months). Little is known regarding long-term outcome. Our objective is to evaluate the potential predictor role of body composition at ICU admission evaluated with CT scan and long-term mortality (2 years).
Methods: post-hoc analysis of a prospective observational study. Body composition evaluated at the level of third lumbar vertebra (L3) was analyzed with dedicated software that automatically calculated the areas (mm2), determined the tissue composition by a Hounsfield Unit (H.U.) and extracted fat component. Cox regression analysis was adopted to evaluate the association between statistically significant muscle parameters at univariate descriptive analysis and 2-years survival.
Results: fifty-one patients were included. Patient alive at follow-up had higher muscle area than nonsurvivors, 156 [128-185] versus 110 [95.1-143] cm2 (p=0.001). No significant difference regarding fat area was observed in survivors compared to nonsurvivors: 27.7 [17.6-38.52] versus 41.6 [26-54.6], respectively (p=0.132).
Total muscle area was significantly associated with 2-years mortality with HR 1.01 (1.00-1.02, p=0.049).
Conclusion: total muscle but not fat area evaluated at L3 at ICU admission is a prognostic marker of mortality at long-term follow-up in critically ill patients.
Trial registration: the study NUTRITI was registered on ClinicalTrials.gov (Identifier: NCT05473546 on 26 July 2022).
Clinical efficacy analysis of arthroscopically assisted Orthcord suture fixation in the treatment of tibial intercondylar eminence fractures: a retrospective case-control study
Authors: Zhang Rongfang , Wang Yuqi , Wang Chunyu , Qiao Yuanxin , Liu HongBo 
Published: October 2024

Abstract

Background: To explore the efficacy of arthroscopically assisted fixation of type II and type III tibial intercondylar eminence fractures with Orthcord sutures.
Method: A retrospective analysis was performed on 80 patients with intercondylar eminence fractures admitted to our hospital from April 2020 to March 2024. According to different surgical methods, the patients were divided into special suture fixation group (n = 30), cannulated screw fixation group (n = 24), and wire fixation group (n = 26). The suture group used arthroscopic orthcord sutures to fix tibial intercondylar eminence fractures, and the cannulated screw group used cannulated compression screws for fixation. Patients in the wire group underwent arthroscopic wire fixation. The basic information of all patients was collected and followed up for 1 year. The Lysholm score of the knee joint was performed at 3 months and 1 year after surgery. The patients' general data, surgical conditions, operation time, blood loss, hospitalization costs, postoperative recovery (Lysholm score of knee joint at 3 months and 1 year after surgery) and other data were analyzed by variance analysis. P < 0.05 was considered statistically significant.
Result: There was no statistical difference in the general data of all patients. One-year follow-up showed that all patients had achieved bone healing without infection, displacement, or bone malformation. The hospitalization time in the wire group was (11 ± 1.02) days, the screw group was (11.58 ± 1.61) days, and the Orhtcord suture group was shortened to (10.03 ± 1.07) days. The differences among the three groups were statistically significant (P < 0.05). At the same time, the cost of Orhtcord suture surgery (1310.7 ± 0.29) $ was significantly lower than that of the other two groups (P＜0.05). The operation time of the suture group (68.13±1.11min) was significantly shorter than that of the wire group (76.76±11.57min) and the screw group (90.62±1.99min) (P＜0.05). In the follow-up, the score of Orhtcord suture 3 months after operation (94.07±2.72 points) was better than that of the wire group (90.23±5.23 points) and the screw group (90.37±5.41 points); the difference was statistically significant (P＜0.05). However, there was no statistically significant difference in the Lysholm score of the three groups of patients 6 months after operation (96.26±1.89, 96.33±2.44, 97.3±1.70) (P＞0.05).
Conclusion: The use of Orhtcord sutures in the arthroscopically assisted treatment of intercondylar ridge fractures can shorten the length of hospital stay and surgery, while greatly reducing hospitalization costs. It can achieve better short-term (3 months) recovery effects while avoiding secondary surgery, and ultimately show no weaker fixation effect than conventional screws and wires when fully weight-bearing is restored.
RETRACTED: Research on Childhood Asthma and Vitamin D: A Bibliometric Analysis
Authors: Liu NaiXu , Luo Fei , Chen XiaoRui , Wu ZhaoRong , Zhang Sha , Zhai SiMing , Ding YaLi , Wang YuanYuan , Tao JiaLei , Yuan Bin 
Published: October 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Validation a new malnutrition screening tool for hospitalized pregnant women in Vietnam
Authors: Nguyen Thi Thu Lieu , Doan Thu Huyen , Ha Kieu Trang , Le Hien Anh , Tran Thi Tu Anh , Le Thi Thanh Xuan , Le Thi Huong , Luu Thi My Thuc 
Published: October 2024

Abstract

Background
The Vietnamese Obstetric Malnutrition Screening Tool (Obstetric MST) is a questionnaire designed to assess the nutrition status of hospitalized pregnant women. The aim of this study was to evaluate the validity and reliability of this questionnaire among inpatients in Vietnam.
Methods
200 pregnant women admitted to the National Hospital of Obstetrics and Gynecology, Vietnam from November 2023 to January 2024. Nutritional risk according to Obstetric MST was compared with the FIGO nutrition checklist, the obstetric nutritional risk screening, the composite diagnostic criteria, and the estimated fetal weight. Sensitivity, specificity, Positive Predictive Values (PPV), Negative Predictive Values (NPV), receiver operator characteristics curve, and the best cut-off scores were determined. Interrater reliability was decided to utilize kappa measurements.
Results
Using Obstetric MST, the optimal cut-off score to identify malnourished pregnant women was one, with 62.5% of patients to be at risk of malnutrition. The percentage agreement between dietitian and nurse was 98.0%, with excellent interrater reliability [kappa value = 0.96 (95% CI 0.94–1.00)]. Obstetric MST had good sensitivity (80.65% − 90.70%), low specificity (40.11% − 45.22%), low PPV (12.80% − 31.20%), and high NPV (92.00% − 97.33%). The area under the curves for Obstetric MST were acceptable (above 0.6).
Conclusions
The Obstetric MST is a valid and reliable nutrition screening tool for determining malnutrition risk in hospitalized pregnant women.
Long-term Outcomes and Prognostic Factors of Eye-preserving Treatment with Particle Beam Radiotherapy for Orbital Malignancies
Authors: Hu Weixu , Cai Qiong , Gao Jing , Hu Jiyi , Huang Qingting , Zhang Haojiong , Kong Lin 
Published: October 2024

Abstract

Background
This retrospective study report the clinical experience of eye-preserving treatment follow by particle beam radiotherapy (IMPT or CIRT) for orbital malignancies. And to evaluate prognostic factors for orbital and lacrimal gland tumors.
Methods
Sixty-two patients with orbital malignancies were identified in the records of a single center between 2015 and 2021. Sixty-one patients met inclusion criteria. All of the patients received eye-preserving treatment before PBRT. Majority of the patients (91.8%) were treatment with CIRT. Clinical data, treatment modality, local control, metastases and survivals and visual outcomes, as well as associated prognostic indicators were were assessed.
Results
Sixty-one patients were followed with a median of 40.7 months (44.3 months for surviving patients). The 3- and 5-year DSS and LC rates were 88.1% and 69.9%, and the 3- and 5-year DMC rates were 77.5% and 74.2% for entire orbital malignancies. For lacrimal gland carcinoma, the 5-year DSS, LC, DMC, and PFS rates were 83.3%, 64.8%, 66.8%, and 53.4%. Tumor size, T stage, extraorbital invasion, and bone invasion influenced survivals. No grade 3 or higher acute toxicities were observed. A total of 8 patients experienced grade 3–4 visual impairment.
Conclusions
Particle radiotherapy following eye-preserving treatment provided a favorable local control and survivals with moderate acute and late toxicities, even in patients with unresectable disease. Particle radiotherapy was a promising strategy for management of orbital tumors.
Laser cleaning of insect residue with a TEA-CO2 -laser in shockwave regime
Authors: Rathmann Lewin , Radel Tim 
Published: October 2024

Abstract

Nowadays, much effort is put into the development of laminar flow technologies for next generation aircrafts creating laminar flow in areas around the leading edge of wings of an airplane. Laminar flow reduces drag at aero plane wings thus reducing environmental pollution and costs due to saved kerosene. Nevertheless, three dimensional disturbances like insect residues, if reaching a threshold height, cause a breakdown in laminar air flow turning it into a turbulent one. Consequently, these insect residues need to be removed repeatedly. Therefore, insect residues were artificially applied on 1.4544.9 steel and Titanium Grade 5 and removed using a TEA-CO2 laser in multiple cleaning cycles. The cleaned area was investigated in terms of process influence on the base material using micro hardness measurements, CLSM and SEM imaging of the topography and grain structure. This paper presents a way of significantly reducing (by 84%) the inhomogeneously distributed insect residue without any identified alteration of the base material regarding hardness, topography, or grain structure.
The efficacy of the pull-out and all-inside techniques for the treatment of Laprad type II medial meniscus posterior root tear
Authors: Shen Zheyuan , Wu Rong , Cai Dan , Li Heng , Peng Qiaoying , Guo Songhua , Zhanfeng Zhang , Zhang Zhanfeng 
Published: October 2024

Abstract

Purpose To investigate the therapeutic effect of Pull-out technique and All-inside technique on Laprad type II medial meniscus posterior root tear (MMPRT).Methods A total of 95 patients were included in this study. Kellgren Lawrence (K-L) grade was recorded by knee X-ray after surgery, and knee cartilage injury grade, subchondral cyst, subchondral edema, insufficiency fracture, meniscal extrusion and meniscal healing were recorded by MRI. International Knee Literature Committee Knee Assessment Scale (IKDC) score, Lysholm score and VAS score were used to evaluate knee joint function.Results There were no significant differences in K-L grade, knee cartilage injury grade, subchondral cyst, subchondral edema and insufficiency fracture between two groups (p > 0.05). The extrusion rate and degree of medial meniscus in pull-out repair group were 88.68%, 3.43 ± 0.71mm, while those in the all-inside repair group were 90.48%, 3.41 ± 0.80mm, with no statistical difference (p > 0.05). There were no significant differences in postoperative IKDC scores and Lysholm scores (p > 0.05).Conclusion Both pull-out repair and all-inside repair can improve knee joint function in the treatment of Laprad type II PMMRT.