bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neck circumference might predict gestational diabetes mellitus in Han Chinese women: A nested case–control study
Authors: He Fang , He Hua , Liu Wenqi , Lin Junyu , Chen Bingjun , Lin Yucong , Zhao Yitao , Tao Wen , Xia Xuefeng 
Published: September 2016

AbstractAims/IntroductionA large neck circumference might be an indicator of metabolic syndrome and its components, and for certain patients is more practical as an index than waist circumference. The demarcation value for neck circumference that suggests metabolic syndrome appears to vary by ethnic group. Gestational diabetes mellitus is considered a component of metabolic syndrome in pregnant women. We investigated whether neck circumference in Han Chinese women is associated with gestational diabetes mellitus in early pregnancy, and determined a predictive demarcation value.Materials and MethodsA nested case–control study was carried out with 255 women aged 18–35 years. Gestational diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association through a 2‐h, 75‐g oral glucose tolerance test.ResultsOf the total population, 41 (16%) women developed gestational diabetes mellitus by 24–28 weeks of gestation. Neck circumference at gestational week 16 positively correlated with pre‐pregnancy waist circumference, bodyweight and body mass index, and maternal age (P = 0.029) and hemoglobin A1c at gestational week 24 (P ≤ 0.001). By binary logistic regression, neck circumference was an independent predictor of gestational diabetes mellitus (odds ratio 1.840, 95% confidence interval 1.040–3.254; P = 0.036). According to the receiver operating characteristic curve, for predicting gestational diabetes mellitus the optimal demarcation for neck circumference at gestational week 16 was 35.15 cm.ConclusionsNeck circumference is a viable tool to screen for gestational diabetes mellitus. In this population of pregnant Han Chinese women, a neck circumference of ≥35.15 cm was a predictor of gestational diabetes mellitus.
Daily Experiences and Relationship Well‐Being: The Paradoxical Effects of Relationship Identification
Authors: Auger Emilie , Menzies‐Toman Danielle , Lydon John E. 
Published: September 2016

AbstractObjectiveEven couples in healthy romantic relationships experience conflict at times. We examine whether relationship identification (the extent to which the relationship is incorporated into the self) predicts immediate reactivity to partner transgressions and also promotes global resilience over time.MethodSixty‐three couples participated in a 2‐week event‐contingent diary study.ResultsOn a daily basis, experiencing more partner transgressions than usual predicted decreases in relationship well‐being and increases in negative affect. This within‐person association was stronger for those high in relationship identification. However, after 2 weeks, changes in global relationship evaluations of low identifiers, but not of high identifiers, were contingent on the accumulation of partner transgressions and the degree of negative affect in response to these daily transgressions.ConclusionsThis study suggests that internalizing a relationship into the self does not blind intimates to immediate negative events but rather provides a basis for their global relationship evaluations that is not contingent on recent events.
The story of cystic fibrosis 1965–2015
Authors: Massie John , Robinson Phillip J , Cooper Peter J 
Published: September 2016

AbstractThere have been dramatic changes in the care of children with cystic fibrosis (CF) from 1965 to 2015. The initial improvements were the result of incremental gains in medical knowledge and better use of available therapies. Some CF‐specific drugs were developed (recombinant human DNase and purified tobramycin for inhalation), but these simply delayed the progression of the lung damage. The discovery of the CF transmembrane conductance regulator gene in 1989 created an explosion of knowledge of airway biology and CF pathophysiology. Now mutation‐specific therapy to potentiate mutated CF transmembrane conductance regulator is available for some patients with CF and is transforming their lives. Further advances are eagerly anticipated to benefit all patients with CF.
Evaluation of the effect of fluconazole on the pharmacokinetics of cyclosporin A in healthy dogs after a single dose and at steady‐state
Authors: Pieper J. B. , Dirikolu L. , Campbell K. L. , Li Z. , Mitchell M. A. 
Published: September 2016

The aim of the study was to describe the effect of fluconazole on the pharmacokinetics of cyclosporin A in healthy dogs when investigated as a single dose and at steady‐state. Five healthy adult dogs were used in the study in a crossover design receiving either 5 mg/kg of cyclosporin A (CsA) alone or 5 mg/kg of fluconazole with 2.5 mg/kg of cyclosporin A (CsA/Flu) for 35 days. Pharmacokinetic curves were performed on day 1 and day 35 in addition to sampling trough and suspected peak concentrations (C2) twice weekly with LC/MS/MS. There was no statistically significant difference noted in any pharmacokinetic value (AUC0‐inf. [day 1, P = 0.225], AUCtau [day 35, P = 0.225], t½ [day 1, P = 0.279; day 35, P = 0.686], and Cmax [day 1, P = 0.225; day 35, P = 0.225]) between the treatment groups by sampling day. There was a statistically significant increase in AUC (CsA P = 0.043; CsA/Flu P = 0.043) and t½ (CsA P = 0.042, CsA/Flu P = 0.042) over time within each group. There were no significant differences in the Cmax (CsA P = 0.08; CsA/Flu P = 0.08) when comparing day 1 vs. day 35. Steady‐state cyclosporine concentrations were achieved by day 10 in both groups. Subjectively, individual variability was noted among the dogs and a much larger sample size would be beneficial in a future study.
McmA‐dependent and ‐independent regulatory systems governing expression of ClrB‐regulated cellulase and hemicellulase genes in Aspergillus nidulans
Authors: Li Nuo , Kunitake Emi , Aoyama Miki , Ogawa Masahiro , Kanamaru Kyoko , Kimura Makoto , Koyama Yasuji , Kobayashi Tetsuo 
Published: September 2016

SummaryFungal cellulolytic and hemicellulolytic enzymes are promising tools for industrial hydrolysis of cellulosic biomass; however, the regulatory network underlying their production is not well understood. The recent discovery of the transcriptional activators ClrB and McmA in Aspergillus nidulans implied a novel regulatory mechanism driven by their interaction, experimental evidence for which was obtained from transcriptional and DNA‐binding analyses in this study. It was found that ClrB was essential for induced expression of all the genes examined in this study, while McmA dependency of their expression was gene‐dependent. DNA‐binding studies revealed McmA assisted in the recruitment of ClrB to the cellulose‐responsive element (CeRE) in the promoters of eglA and eglB, expression of which was significantly reduced in the mcmA mutant. The CCG triplet within the CeRE served as the recognition sequence for the ClrB monomer. In contrast, ClrB did not require McmA for binding as a homodimer to the CGGN8CCG sequences in the promoter of mndB, expression of which was affected less in the mcmA mutant than in all other examined genes. Thus, there are two types of ClrB‐mediated regulation: McmA‐assisted and McmA‐independent. This novel McmA–ClrB synergistic system provides new insights into the complex regulatory network involved in cellulase and hemicellulase production.
Self‐Regulatory Fatigue: A Missing Link in Understanding Fibromyalgia and Other Chronic MultiSymptom Illnesses
Authors: Nes Lise Solberg , Ehlers Shawna L. , Whipple Mary O. , Vincent Ann 
Published: September 2016

AbstractObjectivePatients with chronic multisymptom illnesses such as fibromyalgia syndrome (FMS) are experiencing a multitude of physical and mental challenges. Facing such challenges may drain capacity to self‐regulate, and research suggests patients with these illnesses may experience self‐regulatory fatigue (SRF). This study sought to examine whether SRF can be associated with quality of life (QoL) in patients with FMS.MethodsPatients (N = 258) diagnosed with FMS completed self‐report measures related to demographics, SRF (Self‐Regulatory Fatigue 18 [SRF‐18]), anxiety (Generalized Anxiety Disorder questionnaire [GAD‐7]), depression (Patient Health Questionnaire [PHQ‐9]), physical fatigue (Multidimensional Fatigue Inventory [MFI]), symptoms related to FMS (Fibromyalgia Impact Questionnaire [FIQ]), and QoL (36‐Item Short‐Form Health Survey [SF‐36]).ResultsHierarchical regressions showed higher SRF to be associated with lower QoL in terms of lower overall physical QoL, with subscales related to physical functioning, role limitations—physical, bodily pain, and general health (all P's > 0.001), as well as lower overall mental QoL, with subscales related to vitality, social functioning, role limitations—emotional, and mental health (all P's > 0.001). Including traditional predictors such as anxiety, depression, physical fatigue, and FMS‐related symptoms as covariates in the analyses reduced the link between SRF and QoL somewhat, but the associations remained generally strong, particularly for SRF and mental QoL.ConclusionThis is the first study to show higher SRF relating to lower QoL for patients with FMS. Results suggest that SRF is distinct from anxiety, depression, and fatigue, and predicts QoL above and beyond these traditional factors in the area of chronic multisymptom illnesses such as FMS. SRF may be a “missing link” in understanding the complex nature of chronic multisymptom illnesses.
N‐terminal pro‐B‐type natriuretic peptide diagnostic algorithm versus American Heart Association algorithm for Kawasaki disease
Authors: Dionne Audrey , Meloche‐Dumas Léamarie , Desjardins Laurent , Turgeon Jean , Saint‐Cyr Claire , Autmizguine Julie , Spigelblatt Linda , Fournier Anne , Dahdah Nagib 
Published: September 2016

AbstractBackgroundDiagnosis of Kawasaki disease (KD) can be challenging in the absence of a confirmatory test or pathognomonic finding, especially when clinical criteria are incomplete. We recently proposed serum N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) as an adjunctive diagnostic test.MethodsWe retrospectively tested a new algorithm to help KD diagnosis based on NT‐proBNP, coronary artery dilation (CAD) at onset, and abnormal serum albumin or C‐reactive protein (CRP). The goal was to assess the performance of the algorithm and compare its performance with that of the 2004 American Heart Association (AHA)/American Academy of Pediatrics (AAP) algorithm.ResultsThe algorithm was tested on 124 KD patients with NT‐proBNP measured on admission at the present institutions between 2007 and 2013. Age at diagnosis was 3.4 ± 3.0 years, with a median of five diagnostic criteria; and 55 of the 124 patients (44%) had incomplete KD. CA complications occurred in 64 (52%), with aneurysm in 14 (11%). Using this algorithm, 120/124 (97%) were to be treated, based on high NT‐proBNP alone for 79 (64%); on onset CAD for 14 (11%); and on high CRP or low albumin for 27 (22%). Using the AHA/AAP algorithm, 22/47 (47%) of the eligible patients with incomplete KD would not have been referred for treatment, compared with 3/55 (5%) with the NT‐proBNP algorithm (P < 0.001).ConclusionThis NT‐proBNP‐based algorithm is efficient to identify and treat patients with KD, including those with incomplete KD. This study paves the way for a prospective validation trial of the algorithm.
Congenital heart disease at Laos Children's Hospital: Two year experience
Authors: Hwang In‐Chang , Sisavanh Malouny , Billamay Somxay , Phangmanixay Sommanikhone , Oudavong Bounleua , Kang Jeehoon , Kwon Bo Sang , Kim Gi Beom , Bae Eun Jung , Noh Chung Il , Choi Jung Yun 
Published: September 2016

AbstractBackgroundManagement of congenital heart disease (CHD) in developing countries is challenging because of limited access to health‐care facilities and socioeconomic limitations. The aim of this study was to describe the recent experience with CHD at Children's Hospital, Vientiane, Laos, the only pediatric referral hospital in the country.MethodsFrom July 2013 to November 2015, 1009 echocardiograms were carried out in 797 individuals who visited Children's Hospital, in whom CHD was identified in 213. Demographic characteristics, echocardiography and age at first CHD diagnosis on echocardiogram were compared by residential area.ResultsAmong the 213 patients, the most frequent anomalies, in descending order, were ventricular septal defect, atrial septal defect, patent ductus arteriosus, and tetralogy of Fallot. Moderate or severe CHD requiring surgery or intervention was detected in 137 patients; median age at initial diagnosis was 6.0 months (IQR, 1.5–29.8). Among those with moderate or severe CHD, 89 patients were from rural areas and 48 from the capital area. The proportion of patients from rural areas older than 1 and 3 years at diagnosis was 46.1% and 32.6%, respectively. In contrast, patients from the capital area were diagnosed at a significantly earlier age: 16.7% at age >1 year and 6.2% at age >3 years (both P < 0.001 vs rural areas).ConclusionsDiagnosis of CHD requiring surgery is delayed in Laos, especially in rural areas. Better education and training of local medical staff, and greater access to medical advice are required to improve CHD care in Laos.
Pneumococcal vaccination reduces the risk of community‐acquired pneumonia in children
Authors: Hasegawa Junko , Mori Mitsuru , Ohnishi Hirofumi , Tsugawa Takeshi , Hori Tsukasa , Yoto Yuko , Tsutsumi Hiroyuki 
Published: September 2016

AbstractBackgroundThe seven‐valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, after which there was a rapid decline in invasive pneumococcal disease. There are few data, however, on the effectiveness of PCV7 against community‐acquired pneumonia (CAP). We conducted an ambispective cohort study among children aged 0–6 years old who attended day‐care centers.MethodsA total of 624 children at 10 day‐care centers in Sapporo, Japan participated in the study. The parents reported whether their child had received PCV7 one or more times, as well as the exact dates of vaccination from records in maternal and child health handbooks marked by pediatricians. Each CAP event was reported by parents according to doctor diagnosis. A Cox proportional hazards regression model was used to calculate the hazard ratio (HR) and 95%CI of CAP incidence reduced by PCV7 inoculation.ResultsDuring the observational period, 94 subjects contracted CAP. After adjusting for potentially confounding variables, inoculation with PCV7 was significantly associated with a reduced risk of CAP (HR, 0.22; 95%CI: 0.13–0.34). On stratified analysis by age, PCV7 was significantly associated with a reduced risk of CAP in both children aged <3 years (HR, 0.31; 95%CI: 0.14–0.71), and those ≥3 years (HR, 0.20; 95%CI: 0.09–0.43).ConclusionPCV7 is highly effective in reducing the risk of CAP in children attending day‐care centers.
Supraspinal control of spinal reflex responses to body bending during different behaviours in lampreys
Authors: Hsu Li‐Ju , Zelenin Pavel V. , Orlovsky Grigori N. , Deliagina Tatiana G. 
Published: September 2016

Key points
Spinal reflexes are substantial components of the motor control system in all vertebrates and centrally driven reflex modifications are essential to many behaviours, but little is known about the neuronal mechanisms underlying these modifications.
To study this issue, we took advantage of an in vitro brainstem–spinal cord preparation of the lamprey (a lower vertebrate), in which spinal reflex responses to spinal cord bending (caused by signals from spinal stretch receptor neurons) can be evoked during different types of fictive behaviour.
Our results demonstrate that reflexes observed during fast forward swimming are reversed during escape behaviours, with the reflex reversal presumably caused by supraspinal commands transmitted by a population of reticulospinal neurons.
NMDA receptors are involved in the formation of these commands, which are addressed primarily to the ipsilateral spinal networks.
In the present study the neuronal mechanisms underlying reflex reversal have been characterized for the first time.
AbstractSpinal reflexes can be modified during different motor behaviours. However, our knowledge about the neuronal mechanisms underlying these modifications in vertebrates is scarce. In the lamprey, a lower vertebrate, body bending causes activation of intraspinal stretch receptor neurons (SRNs) resulting in spinal reflexes: activation of motoneurons (MNs) with bending towards either the contralateral or ipsilateral side (a convex or concave response, respectively). The present study had two main aims: (i) to investigate how these spinal reflexes are modified during different motor behaviours, and (ii) to reveal reticulospinal neurons (RSNs) transmitting commands for the reflex modification. For this purpose in in vitro brainstem–spinal cord preparation, RSNs and reflex responses to bending were recorded during different fictive behaviours evoked by supraspinal commands. We found that during fast forward swimming MNs exhibited convex responses. By contrast, during escape behaviours, MNs exhibited concave responses. We found RSNs that were activated during both stimulation causing reflex reversal without initiation of any specific behaviour, and stimulation causing reflex reversal during escape behaviour. We suggest that these RSNs transmit commands for the reflex modification. Application of the NMDA antagonist (AP‐5) to the brainstem significantly decreased the reversed reflex, suggesting involvement of NMDA receptors in the formation of these commands. Longitudinal split of the spinal cord did not abolish the reflex reversal caused by supraspinal commands, suggesting an important role for ipsilateral networks in determining this type of motor response. This is the first study to reveal the neuronal mechanisms underlying supraspinal control of reflex reversal.
Entrando en materia: novela, poesía y cultura material en El ruido de las cosas al caer
Authors: González Aníbal 
Published: September 2016

<p>Este ensayo reflexiona sobre el papel simbólico de los objetos materiales en la novela <em>El ruido de las cosas al caer</em> de Juan Gabriel Vásquez y su relación con las referencias a la poesía en el texto. El ensayo argumenta que esta novela examina los límites de la representación realista en la novela, invitando al lector a una reflexión sobre el carácter móvil y fluido de las cosas, los objetos que nos rodean, los cuales pese a su materialidad no necesariamente constituyen puntos de apoyo firmes para la construcción de un relato veraz. La poesía surge entonces en el seno de la novela como un elemento añadido que intenta suplementar la “fluidez” de las cosas mediante el artificio de la forma poética.</p>
La literatura brasileña contemporánea y su crítica
Authors: Schøllhammer Karl Erik 
Published: September 2016

<p>El ensayo se propone mostrar que existen ejemplos en la literatura contemporánea de escenarios para la relación Mundo y Nación que escapan al modelo occidental de centro y periferia, de influencia y autonomía y de sumisión y resistencia. Sugiere que el desafío para el escritor brasileño contemporáneo es tratar los temas nacionales con un sentimiento que se alimenta de una cierta intimidad global y de una visión, o un <em>Imaginario Global</em>, cuyo perspectivismo refleja la inserción de Brasil en el panorama mundial. </p>
LA CONEXIDAD CONTRACTUAL Y LOS EFECTOS RELATIVOS DE LOS NEGOCIOS JURÍDICOS APLICADOS A LOS CONTRATOS DE PAQUETES TURÍSTICOS EN COLOMBIA
Authors: Cataño-Berrío Sandra Eliana , Wills-Betancur Luz María 
Published: September 2016

<p>Este artículo tiene como propósito evidenciar la configuración de una nueva excepción al efecto relativo de los negocios jurídicos, mediante el análisis de la figura de la contratación conexa aplicada a los contratos de paquetes turísticos celebrados en Colombia. Para ello se realiza, en primer lugar, un acercamiento a las relaciones que se establecen en la conexidad contractual, entre empresarios y con los usuarios. En segundo lugar, se presenta una caracterización del contrato de paquete turístico en Colombia. Para concluir, en tercer lugar, con un análisis de la relatividad de los efectos de los negocios en los contratos conexos de servicios turísticos. Se trata de una investigación cualitativa documental que privilegia el uso de fuentes primarias de información, mediante las cuales se presentan las complejidades de este fenómeno de la contratación privada contemporánea, las discusiones sobre los alcances de los efectos del negocio jurídico de servicios turísticos y la tendencia hacia una mayor protección de los usuarios y consumidores, que podría estar originando una nueva excepción a la relatividad negocial. </p>
Genome Sequence of Avian Escherichia coli Strain IHIT25637, an Extraintestinal Pathogenic E. coli Strain of ST131 Encoding Colistin Resistance Determinant MCR-1
Authors: Ewers Christa , Göttig Stephan , Bülte Maria , Fiedler Sophie , Tietgen Manuela , Leidner Ursula , Heydel Carsten , Bauerfeind Rolf , Semmler Torsten 
Published: September 2016

ABSTRACT

Sequence type 131 (ST131) is one of the predominant
Escherichia coli
lineages among extraintestinal pathogenic
E. coli
(ExPEC) that causes a variety of diseases in humans and animals and frequently shows multidrug resistance. Here, we report the first genome sequence of an ST131-ExPEC strain from poultry carrying the plasmid-encoded colistin resistance gene
mcr-1
.
H9N2 Influenza A Virus Isolated from a Greater White-Fronted Wild Goose (
Anser albifrons
) in Alaska Has a Mutation in the PB2 Gene, Which Is Associated with Pathogenicity in Human Pandemic 2009 H1N1
Authors: Reeves Andrew B. , Ip Hon S. 
Published: September 2016

ABSTRACT
We report here the genomic sequence of an H9N2 influenza A virus [A/greater white-fronted goose/Alaska/81081/2008 (H9N2)]. This virus shares ≥99.8% identity with a previously reported virus. Both strains contain a G590S mutation in the polymerase basic 2 (PB2) gene, which is a pathogenicity marker in the pandemic 2009 H1N1 virus when combined with R591.
First Complete Genome Sequence of the Skin-Improving Lactobacillus curvatus Strain FBA2, Isolated from Fermented Vegetables, Determined by PacBio Single-Molecule Real-Time Technology
Authors: Nakano Kazuma , Shiroma Akino , Tamotsu Hinako , Ohki Shun , Shimoji Makiko , Ashimine Noriko , Shinzato Misuzu , Minami Maiko , Nakanishi Tetsuhiro , Teruya Kuniko , Satou Kazuhito , Suzuki Chise , Kimoto-Nira Hiromi , Kobayashi Miho , Mizumachi Koko , Aoki Reiji , Miyata Satoshi , Yamamoto Kazue , Ohtake Yasuyuki , Eguchi-Ogawa Tomoko , Moriya Naoko , Hagi Tatsuro , Nomura Masaru , Hirano Takashi 
Published: September 2016

ABSTRACT

The first complete genome sequence of
Lactobacillus curvatus
was determined by PacBio RS II. The single circular chromosome (1,848,756 bp, G+C content of 42.1%) of
L. curvatus
FBA2, isolated from fermented vegetables, contained low G+C regions (26.9% minimum) and 43 sets of >1,000-bp identical sequence pairs. No plasmids were detected.
Draft Genome Sequence of Salmonella enterica subsp.
enterica
Serovar Putten Strain CRJJGF_00159 (Phylum
Gammaproteobacteria
)
Authors: Gupta Sushim K. , McMillan Elizabeth A. , Jackson Charlene R. , Desai Prerak T. , Porwollik Steffen , McCleland Michael , Hiott Lari M. , Humayoun Shaheen B. , Frye Jonathan G. 
Published: September 2016

ABSTRACT

Here, we report a 4.90 Mbp draft genome sequence of
Salmonella enterica
subsp.
enterica
serovar Putten strain CRJJGF_00159 isolated from food animal in 2004.