bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Prechiasmatic Mouse Model of Subarachnoid Hemorrhage to Measure Long‐Term Cognitive Deficits
Authors: Diwan Deepti , Mehla Jogender , Nelson James W. , Quirk James D. , Song Sheng‐Kwei , Cao Sarah , Meron Benjamin , Mostofa Aminah , Zipfel Gregory J. 
Published: October 2024

AbstractControllable and reproducible animal models of aneurysmal subarachnoid hemorrhage (SAH) are crucial for the systematic study of the pathophysiology and treatment of this debilitating condition. However, current animal models have not been successful in replicating the pathology and disabilities seen in SAH patients, especially the long‐term neurocognitive deficits that affect the survivor's quality of life. Therefore, there is an unmet need to develop experimental models that reliably replicate the long‐term clinical ramifications of SAH – especially in mice where genetic manipulations are straightforward and readily available. To address this need, a standardized mouse SAH model is developed that reproducibly produced significant and trackable long‐term cognitive deficits. SAH is induced by performing double blood injections into the prechiasmatic cistern – a simple modification to the well‐characterized single prechiasmatic injection mouse model of SAH. Following SAH, mice recapitulated key characteristics of SAH patients, including cerebral edema measured by MRI ‐ an indicator of early brain injury (EBI), neuroinflammation, apoptosis, and long‐term cognitive impairment. This newly developed SAH mouse model is considered an ideal paradigm for investigating the complex SAH pathophysiology and identifying novel druggable therapeutic targets for treating SAH severity and SAH‐associated long‐term neurocognitive deficits in patients.
Photoinduced Zn‐Air Battery‐Assisted Self‐Powered Sensor Utilizing Cobalt and Sulfur Co‐Doped Carbon Nitride for Portable Detection Device
Authors: Chen Yun , Ge Yuhang , Yan Yuting , Xu Li , Zhu Xingwang , Yan Pengcheng , Ding Penghui , Li Huaming , Li Henan 
Published: October 2024

AbstractMost self‐powered electrochemical sensors (SPESs) are limited by low open circuit voltage and power density, leading to a narrow detection range and low sensitivity. Herein, a photoinduced Zn‐air battery‐assisted SPES (ZAB‐SPES) is proposed based on cobalt and sulfur co‐doped carbon nitride with the cyano group (Co, S‐CN). The cyano functionalization remarkably enhances visible light utilization, and the cyano moiety acts as an electron‐withdrawing group to promote electron enrichment. Co and S co‐doping can create a p–n homojunction within carbon nitride, enabling the efficient migration and separation of carriers, thereby significantly improving the performance of the oxygen reduction reaction. The synergistic effects endow Co, S‐CN photocathode with an open circuit voltage of 1.85 V and the maximum power density of 43.5 µW cm−2 in the photoinduced ZAB. Employing heavy metal copper ions as the target model, the photoinduced ZAB‐SPES exhibited dual‐mode and sensitive detection. Furthermore, a portable detection device based on the photoinduced ZAB‐SPES is designed and exhibits high linearity in the range of 5 ~ 600 nM with a detection limit of 1.7 nM. This work offers a portable detection method based on the photoinduced ZAB‐SPES in the aquatic environment.
Achieving High Stability and Capacity in Micron‐Sized Conversion‐Type Iron Fluoride Li‐Metal Batteries
Authors: Choi Chiwon , Yoon Hyunmin , Kang Seungyeop , Kim Dong Il , Hong John , Shin Minjeong , Yoo Dong‐Joo , Kim Minkyung 
Published: October 2024

AbstractIron fluoride, a conversion‐type cathode material with high energy density and low‐cost iron, holds promise for Li‐ion batteries but faces challenges in synthesis, conductivity, and cycling stability. This study addresses these issues by synthesizing micron‐sized iron‐fluoride using a simple solid‐state synthesis. Despite a large particle size, a high capacity of 571 mAh g−1 is achieved, which is attributed to the unique surface and internal pores within the iron‐fluoride particles, which provided a large surface area. This is the first study to demonstrate the feasibility of using large iron fluoride particles to enhance the energy density of the electrode and achieve an iron fluoride full cell with high capacity. Also, the cause of the capacity fading is investigated. Electrode delamination from the current collector, which is the main cause of capacity fading in early cycles, is resolved using a carbon‐coated aluminum (C/Al) current collector. Moreover, iron (Fe) dissolution and the deposition of dissolved Fe on the Li metal also contributed significantly to the degradation. Localized high‐concentration electrolytes (LHCEs) suppress iron dissolution and Li dendrite growth, resulting in long‐cycle stability for 300 cycles. This study provides insights into the further development of conversion‐type metal fluorides across various compositions.
A rare case of disseminated amebiasis in a patient on biologic therapy for chronic rhinosinusitis
Authors: Omiunu Ariel , Brown Lindsey , Kayastha Darpan , Manes R. Peter 
Published: October 2024

Key points
Dupilumab targets Th2‐associated inflammatory mediators to reduce disease burden in CRSwNP.
While rare, potential sequelae include viral, helminth, and potentially amebic infections.
Chaperon‐Abgeleitete Kupfer(I)‐Bindende Peptidnanofibrillen stören die Kupferhomöostase in Krebszellen
Authors: Jeena M. T. , Link Julian , Zhang Jian , Harley Iain , Turunen Petri , Graf Robert , Wagner Manfred , Baptista Luis Andre , Jonker Hendrik R. A. , Cui Liyang , Lieberwirth Ingo , Landfester Katharina , Rao Jianghong , Ng David Y. W. , Weil Tanja 
Published: October 2024

AbstractKupfer (Cu) ist ein Übergangsmetall, das eine entscheidende Rolle im Zellstoffwechsel spielt. Die Cu+‐Homöostase ist in vielen Krebsarten hochreguliert und trägt zur Tumorentstehung bei. Therapeutische Strategien zur gezielten Beeinflussung der Cu+‐Homöostase in Krebszellen werden jedoch selten erforscht, da kleine Cu+‐Chelatoren eine geringere Bindungsaffinität aufweisen als intrazelluläre Cu+‐Chaperone, Enzyme oder Liganden. Um dieses Problem anzugehen, stellen wir einen supramolekularen Ansatz vor, der von Cu+‐Chaperonen inspiriert ist, um die Cu+‐Homöostase in Krebszellen zu stören und somit den programmierten Zelltod zu induzieren. Das Peptid Nap‐FFMTCGGCR bildet in Krebszellen Nanofibrillen aus, die aufgrund des einzigartigen MTCGGC‐Motivs, das in intrazellulären Cu+‐Chaperonen konserviert ist, eine hohe Bindungsaffinität und Selektivität für Cu+ aufweisen. Nap‐FFMTCGGCR zeigt Zytotoxizität gegenüber dreifach negativen Brustkrebszellen (MDA‐MB‐231), beeinträchtigt die Aktivität des Cu+‐abhängigen Co‐Chaperons Superoxid‐Dismutase 1 (SOD1) und induziert oxidativen Stress. Im Gegensatz dazu hat Nap‐FFMTCGGCR nur minimale Auswirkungen auf normale HEK 293T‐Zellen. Kontrollpeptide zeigen, dass Selbstassemblierung und Cu+‐Bindung synergistisch wirken müssen, um die Cu+‐Homöostase erfolgreich zu stören. Wir zeigen, dass die durch Assemblierung verstärkte Affinität für Metallionen neue therapeutische Strategien eröffnet, um krankheitsrelevante Metallionen‐Homöostase anzugehen.
What am I looking at? Graduate student accuracy in identification of anatomic structures/landmarks on swallow imaging
Authors: Fleck Christy , Allen Katie 
Published: October 2024

AbstractSpeech‐language pathologists need to accurately identify structures/landmarks on swallow imaging. Foundational learning begins in graduate training. This study aimed to determine graduate student accuracy at identifying anatomical structures/landmarks during swallow evaluations and to determine if accuracy was predicted by type of imaging, anatomical structure, case type (i.e., normal/abnormal). Researchers recruited first‐year graduate speech‐language pathology students. Each participant reviewed five static images from lateral radiographic swallow studies and five static images from endoscopic swallow studies across 10 cases. Participants identified key anatomic structures and landmarks by clicking on the structure/landmark within a web‐based platform. Two experienced speech‐language pathologists reviewed and coded participant responses for accuracy. Sixteen graduate speech‐language pathology students participated in a within‐subjects design. Overall participant accuracy in identification of structure/landmarks was 69% (range 46%–88%). Binomial logistic regression was performed to study the effects of anatomical structure, case type (i.e., normal/abnormal), and image type on likelihood of participant accuracy in identifying anatomical structures (X
2(4) = 143.65, p < 0.001). Only anatomical structure was statistically significant (X
2(4) = 187.729, p < 0.001). The model explained 23.2% (Nagelkerke's R squared) of the variance in accuracy and correctly classified 78.4% of cases. Sensitivity was 92.1%, specificity was 47.3%, positive predictive value was 79.84%, and negative predictive value was 72.50%. The area under the ROC curve was 0.754, 95% CI [0.716, 0.791]. Graduate student's ability to correctly identify structures/landmarks overall was lower than desired and accuracy varied per structure. Results have implications for improving graduate student training for identification of structures/landmarks on swallow imaging.
The Big Five Personality Traits and Social Support During the COVID‐19 Pandemic: The Supporters, the Supported, and the Overlooked
Authors: Kratt Luise , Höltmann Gesine , Hutter Swen , Specht Jule 
Published: October 2024

ABSTRACTSocial support can benefit its recipients and even its providers and is especially important in times of crisis. During the COVID‐19 pandemic, support from society and personal networks became particularly crucial but individuals greatly differed in their support reception and provision. The Big Five personality traits may be key to explaining these interindividual differences: In this study, we investigated their impact on the support provided, received and additionally needed during the COVID‐19 pandemic using data collected in October 2020 in a large German sample (N = 3330). The Big Five personality traits predicted support received from the state, civil society and the social network, with extraversion and openness emerging as positive and conscientiousness and emotional stability as negative predictors. The need for additional support was predicted positively by openness and negatively by conscientiousness, emotional stability and agreeableness. Support provision was predicted by all traits, positively by extraversion and openness and negatively by conscientiousness and emotional stability. Notably, agreeableness showed positive associations with social but negative associations with societal support reception and provision. Our findings highlight the importance of personality in social support processes during crises and the need to distinguish between different support sources. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Synthesis, In‐Silico Biochemical Properties, and In‐Vitro Antimicrobial Activity of Some Farmazans‐Sulfonamide Derivatives
Authors: Almehmadi Mazen , Allahyani Mamdouh , Alsuwat Meshari A. , Asif Mohammad 
Published: October 2024

AbstractThe low effectiveness of currently available antibiotics is driving efforts worldwide to generate new antimicrobial drugs. So, we synthesized some new formazan derivatives containing sulfonamide moiety, and assessed their in‐silico biochemical properties as well as in‐vitro antibacterial activity against some pathogenic Gram‐positive (B. subtilis and S. aureus) and Gram‐negative (E. coli and S. thyphi) bacteria and fungi (C. albicans and A. niger). These formazan derivatives were synthesized by condensing sulphanilamide with benzaldehyde in the presence of glacial acetic acid and ethanol produced a Schiff base of sulfonamide (1). After this compound 1 was reacted with substituted benzene diazonium chlorides (2a–g) by condensation reaction yields formazan derivatives (3a–g). The structures of synthesized compounds were characterized on the basis analytical and spectral (IR, 1H‐NMR, and mass) data. Agar diffusion method was utilized to assess the antibacterial activity of the synthesized compounds by measuring the zone of inhibition against tested strains of bacteria and fungi. Ciprofloxacin and ketoconazole were used as reference drugs. The result exhibited that synthesized compounds have demonstrated satisfactory in‐silico biochemical properties as well as significant level of antibacterial activity.
Effect of Macronutrients on Recombinant mCherry Production by Microalga
Authors: Arias Cesar Andres Diaz , Matsudo Marcelo Chuei , Ferreira‐Camargo Livia Seno , Molino João Vitor Dutra , Mayfield Stephen Patrick , de Carvalho João Carlos Monteiro 
Published: October 2024

AbstractThis study sought to evaluate the influence of five macronutrients (acetate, calcium, sulfate, nitrogen, and phosphate) on the cell growth and heterologous mCherry protein production by Chlamydomonas reinhardtii. In the first step, three nitrogen (N) sources were tested (NH4NO3, NaNO3, and NH4Cl), and NH4NO3 was selected as N source for the following step, due to the best results for mCherry protein production. In the second step, a central composite design 25 was employed to evaluate the effect of the five macronutrients. Although all nutrients had effect on maximum biomass concentration, only acetate, nitrogen, and phosphate showed to influence mCherry protein production. By employing the experimental design with small‐scale culture in multiplates and multivariable regression, it was possible to achieve 12 % increase for recombinant protein production.
Decarbonization of Metallurgy and Steelmaking Industries Using Biochar: A Review
Authors: Sarker Tumpa R. , Ethen Dilshad Z. , Nanda Sonil 
Published: October 2024

AbstractThe iron and steelmaking industries play a significant role in the manufacturing sector but result in significant greenhouse gas emissions. Biochar has recently gained attention as a potential substitute for coal in metallurgical processes due to its carbon capture potential. This review explores the potential of biochar as a sustainable substitute for coal in steelmaking industries. Notable research works have shown that substituting biochar in amounts ranging from as low as 5 % to as high as 50 % can be feasible and beneficial in processes such as coke making, iron sintering, blast furnaces, and electric furnaces. The information presented in this review can be applied to create sustainable and competitive alternatives to fossil fuels to help decarbonize metallurgical industries.
On the Replicability of the Thermodynamic Modeling of Spectroscopic Titration Data in the Nickel(II) En System
Authors: Lawler Fenton C. , Storteboom Ryan S. , Rosales‐Lopez Plinio D. , Hoogstra Madison N. , Selvaggio Katherine J. , Chen Trevina , Zogg Krista A. , Heule Dafna L. , Pehrson Noah J. , Baker Aerin E. , Vander Griend Douglas A. 
Published: October 2024

ABSTRACTCharacterizing complicated solution phase systems in situ requires advanced modeling techniques to capture the intricate balances between the many chemical species. Due to the error inherent in any scientific measurement, a spectrophotometric titration experiment with nickel(II) and ethylenediamine (en) was repeated six times using an autotitrator to test the replicability of the data and the consistency of the resulting thermodynamic model. All six datasets could be modeled very tightly (R2 > 99.9999%) with the following eight complexes: [Ni]2+, [Ni2en]4+, [Nien]2+, [Ni2en3]4+, [Nien2]2+, [Ni2en5]4+, [Nien3]2+, and [Nien6]2+. The logK values for the stepwise associative reactions agree with existing literature values for the majority species ([Nienn = 1–3]2+) and matched expectations for the minority species; 95% confidence intervals for each logK value were determined via bootstrapping, which quantifies the variability in the binding constant value that is supported by a given dataset. The repeated experiments, which could not be successfully concatenated together, demonstrate that replication is crucial to capturing all the variability in the logK values. Conversely, bootstrapped confidence intervals across multiple experiments can be readily combined to generate an appropriate range for an experimentally determined binding constant.
Enhancing Quality of Life in Symptomatic Paroxysmal Atrial Fibrillation Patients: A Systematic Analysis of Cognitive Behavioral Therapy Interventions
Authors: Agarwal Pratik , Sethi Yashendra , Goyal Avisham , Padda Inderbir , Fabian Daniel , Emran Talha Bin , Johal Gurpreet , Mareddy Chinmaya 
Published: October 2024

ABSTRACTBackgroundParoxysmal atrial fibrillation (PAF) significantly impacts patients' lives, contributing to morbidity, reduced quality of life (QoL), and psychological distress. Conventional treatment approaches primarily focus on rhythm control through pharmacologic therapy, often overlooking the patient's holistic well‐being.HypothesisCognitive behavioral therapy (CBT), a well‐established intervention for modifying dysfunctional thoughts and behaviors, may provide a beneficial nonpharmacological approach to improving QoL in symptomatic PAF patients.MethodsA systematic review was conducted in accordance with Cochrane methodology and PRISMA guidelines. A comprehensive search was performed using PubMed, Scopus, and Google Scholar to identify relevant studies on the effects of CBT on QoL in PAF patients. Various CBT interventions, including exposure‐based, internet‐delivered, and mindfulness‐based approaches, were analyzed. Study quality was assessed using JBI and Cochrane tools to evaluate the risk of bias.ResultsThe review found that CBT interventions led to statistically significant improvements in several QoL domains, including physical and emotional well‐being. Psychological well‐being and self‐management skills were notably enhanced, as CBT helped address maladaptive cognitive patterns and improved coping strategies. The studies reviewed consistently demonstrated a low risk of bias, indicating reliability in the findings.ConclusionsCBT shows promise as a holistic, nonpharmacological intervention for managing PAF, improving both psychological and physical QoL. However, future research is needed to establish standardized protocols, increase sample sizes, and conduct long‐term follow‐ups to further validate its effectiveness in this population. Incorporating CBT into PAF management could substantially enhance patient outcomes and well‐being.
Toluene Inhalant Addiction and Cardiac Functions in Young Adults: A Comparison of Electrocardiographic and Echocardiographic Parameters
Authors: Karaca Gürkan , Hatipsoylu Erdinç , Ekmekci Ahmet , Yazıcı Ömer Kamil , Kimiaei Ali , Safaei Seyedehtina , Sözen Ahmet Bilge 
Published: October 2024

ABSTRACTBackgroundVolatile substance (thinner) addiction can cause serious cardiac events, such as malignant ventricular arrhythmias, acute coronary syndromes, sudden death syndrome, and dilated cardiomyopathy, as reported in many case studies. We aimed to find echocardiographic and electrocardiographic parameters that could foresee these adverse outcomes in clinical settings.MethodsWe enrolled 32 healthy young adult patients with at least 1 year of thinner addiction and no cardiac symptoms. We also recruited a control group of 30 healthy individuals without any medical problems. Both groups received standard echocardiography and ECG tests. We analyzed the following echocardiographic parameters: LVEDd (left ventricular end‐diastolic diameter), LVESd (left ventricular end‐systolic diameter), mitral valve EF slope, E/A ratio, and aortic and pulmonary valve VTI (velocity time integral). We also measured the corrected (QTc), uncorrected QT intervals, and widest P‐wave values in the ECG. We used the SPSS 13 software for statistical analysis.ResultsThe echocardiographic findings did not differ significantly between the groups. However, the ECG results showed that the thinner addicts had higher values of corrected (QTc), uncorrected QT intervals, and widest P‐wave values than the control group, according to Mann–Whitney U and Student's T test.ConclusionCorrected QT (QTc) and P‐wave duration are increased in individuals with a thinner addiction. These findings may suggest a higher risk of sudden cardiac death, atrial, and ventricular dysrhythmias in the future.
A Multiobjective Approach for E‐Commerce Website Structure Optimization
Authors: Panicker Shina , Kumar T. V. Vijay , Yadav Divakar 
Published: October 2024

ABSTRACTComplex websites comprise a variety of diverse web entities, which require constant restructuring resonating with the latest trends, shifting consumer expectations and market driven changes. Therefore, designing suitable models to optimally restructure such websites is of paramount importance and must take into consideration several factors about the web entities such as display size, download time, type, location in the page, sales likelihood, discounts, and the ongoing trend. A recent study has taken all these attributes into consideration and designed a model based on the Access Score, Interface Score, and Purchase Score. However, this model suffers from certain drawbacks such as it did not address the underlying cohesiveness between these attributes. Further, it provided a single optimal solution to the adaptive website structure optimization (AWSO) problem and relied on the a priori knowledge of weights. The basis of the new proposed model is that there can be more than one optimal solution to the AWSO problem in the real world. The novel tri‐objective optimization model uses NSGA‐II algorithm to simultaneously optimize the attributes and finds advantageous trade‐off solutions without requiring a priori knowledge of weights. The proposed MO‐AWSONSGA‐II model is shown to outperform the existing model proving it better suited for the AWSO problem.
A Comparison Between Three Types of Scaffolds for Pulp Regeneration: A Histological Study on Dogs
Authors: Alshahhoud Aliaa , Rikab Mhd. Salem , Issa Nizar , Manadili Ahmad , Alsayed Tolaibah Yasser 
Published: October 2024

ABSTRACTObjectivesThis study aims to compare the application of three types of normal scaffolds—native chitosan, enzymatically modified chitosan, and blood clot (BC)—on pulp regeneration in the teeth of experimental dogs through histological examination, to determine the quantity and type of new tissues formed within the root canal.Materials and MethodsThe research sample consisted of 32 root canals from 20 premolars of two male local experimental dogs. The sample was randomly divided into a control group, in which no intervention was performed on the teeth, and three experimental groups based on the type of scaffold used: the BC group, the native chitosan combined with BC (NCS + BC) group, and the enzymatically modified chitosan combined with BC (EMCS + BC) group. Mechanical and chemical cleaning of the canals was performed, followed by the application of the studied scaffolds within the root canals. After 3 months, the teeth were extracted and prepared for histological study, where two variables were studied: the percentage of total vital tissue (soft and hard; VT%) and the percentage of soft vital tissue only (ST%). A one‐way ANOVA and Bonferroni tests were used to determine significant differences between the groups at a 95% confidence level.ResultsThe VT% values were significantly higher in the EMCS + BC group compared to both the NCS + BC and BC groups. The ST% values were also significantly higher in the EMCS + BC group compared to the BC group. However, no significant differences in ST% values were observed between the NCS + BC group and either the BC or EMCS + BC groups.ConclusionsWithin the limitations of this study, we conclude that the application of enzymatically modified chitosan scaffolds combined with BC yields superior results in pulp regeneration, which contributes to the formation of pulp‐like tissue and cells resembling odontoblasts, as well as apex closure with tissue resembling bone tissue.