bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of a circadian-relevant gene NR1D1 in brain development: possible involvement in the pathophysiology of autism spectrum disorders
Authors: Goto Masahide , Mizuno Makoto , Matsumoto Ayumi , Yang Zhiliang , Jimbo Eriko F. , Tabata Hidenori , Yamagata Takanori , Nagata Koh-ichi 
Published: March 2017

AbstractIn our previous study, we screened autism spectrum disorder (ASD) patients with and without sleep disorders for mutations in the coding regions of circadian-relevant genes, and detected mutations in several clock genes including NR1D1. Here, we further screened ASD patients for NR1D1 mutations and identified three novel mutations including a de novo heterozygous one c.1499 G > A (p.R500H). We then analyzed the role of Nr1d1 in the development of the cerebral cortex in mice. Acute knockdown of mouse Nr1d1 with in utero electroporation caused abnormal positioning of cortical neurons during corticogenesis. This aberrant phenotype was rescued by wild type Nr1d1, but not by the c.1499 G > A mutant. Time-lapse imaging revealed characteristic abnormal migration phenotypes in Nr1d1-deficient cortical neurons. When Nr1d1 was knocked down, axon extension and dendritic arbor formation of cortical neurons were also suppressed while proliferation of neuronal progenitors and stem cells at the ventricular zone was not affected. Taken together, Nr1d1 was found to play a pivotal role in corticogenesis via regulation of excitatory neuron migration and synaptic network formation. These results suggest that functional defects in NR1D1 may be related to ASD etiology and pathophysiology.
Increased circulating β2-adrenergic receptor autoantibodies are associated with smoking-related emphysema
Authors: Hu Jia-yi , Liu Bei-bei , Du Yi-peng , Zhang Yuan , Zhang Yi-wei , Zhang You-yi , Xu Ming , He Bei 
Published: March 2017

AbstractSmoking is a dominant risk factor for chronic obstructive pulmonary disease (COPD) and emphysema, but not every smoker develops emphysema. Immune responses in smokers vary. Some autoantibodies have been shown to contribute to the development of emphysema in smokers. β2-adrenergic receptors (β2-ARs) are important targets in COPD therapy. β2-adrenergic receptor autoantibodies (β2-AAbs), which may directly affect β2-ARs, were shown to be increased in rats with passive-smoking-induced emphysema in our current preliminary studies. Using cigarette-smoke exposure (CS-exposure) and active-immune (via injections of β2-AR second extracellular loop peptides) rat models, we found that CS-exposed rats showed higher serum β2-AAb levels than control rats before alveolar airspaces became enlarged. Active-immune rats showed increased serum β2-AAb levels, and exhibited alveolar airspace destruction. CS-exposed-active-immune treated rats showed more extensive alveolar airspace destruction than rats undergoing CS-exposure alone. In our current clinical studies, we showed that plasma β2-AAb levels were positively correlated with the RV/TLC (residual volume/total lung capacity) ratio (r = 0.455, p < 0.001) and RV%pred (residual volume/residual volume predicted percentage, r = 0.454, p < 0.001) in 50 smokers; smokers with higher plasma β2-AAb levels exhibited worse alveolar airspace destruction. We suggest that increased circulating β2-AAbs are associated with smoking-related emphysema.
First reported case of per anal endoscopic myectomy (PAEM): A novel endoscopic technique for resection of lesions with severe fibrosis in the rectum
Authors: Rahni David , Toyonaga Takashi , Ohara Yoshiko , Lombardo Francesco , Baba Shinichi , Takihara Hiroshi , Tanaka Shinwa , Kawara Fumiaki , Azuma Takeshi 
Published: March 2017

Background and study aims A 54-year-old man was diagnosed with a rectal tumor extending through the submucosal layer. The patient refused surgery and therefore endoscopic submucosal dissection (ESD) was pursued. The lesion exhibited the muscle retraction sign. After dissecting circumferentially around the fibrotic area by double tunneling method, a myotomy was performed through the internal circular muscle layer, creating a plane of dissection between the internal circular muscle layer and the external longitudinal muscle layer, and a myectomy was completed.The pathologic specimen verified T1b grade 1 sprouting adenocarcinoma with 4350 µm invasion into the submucosa with negative resection margins.
A Comparison of Two Mobile Electrode Arrays for Increasing Mortality of Lake Trout Embryos
Authors: Brown Peter J. , Guy Christopher S. , Meeuwig Michael H. 
Published: March 2017

Abstract
Conservation of sport fisheries and populations of several native fishes in the western United States is dependent on sustained success of removal programs targeting invasive Lake Trout Salvelinus namaycush. Gill-netting of spawning adults is one strategy used to decrease spawning success; however, additional complementary methods are needed to disrupt Lake Trout reproduction where bycatch in gill nets is unacceptable. We developed and tested two portable electrode arrays designed to increase Lake Trout embryo mortality in known spawning areas. Both arrays were powered by existing commercial electrofishing equipment. However, one array was moved across the substrate to simulate being towed behind a boat (i.e., towed array), while the other array was lowered from a boat and energized when sedentary (i.e., sedentary array). The arrays were tested on embryos placed within substrates of known spawning areas. Both arrays increased mortality of embryos (&gt;90%) at the surface of substrates, but only the sedentary array was able to increase mortality to &gt;90% at deeper burial depths. In contrast, embryos at increasingly deeper depths exhibited progressively lower mortality when exposed to the towed array. Mortality of embryos placed under 20 cm of substrate and exposed to the towed array was not significantly different from that of unexposed embryos in a control group. We suggest that the sedentary array could be used as a viable approach for increasing mortality of Lake Trout embryos buried to 20 cm and that it could be modified to be effective at deeper depths.
Received August 12, 2016; accepted November 28, 2016Published online March 3, 2017
Condition-Dependent En Route Migration Mortality of Adult Chinook Salmon in the Willamette River Main Stem
Authors: Keefer Matthew L. , Jepson Michael A. , Naughton George P. , Blubaugh Timothy J. , Clabough Tami S. , Caudill Christopher C. 
Published: March 2017

Abstract
Episodically high adult mortality during migration and near spawning sites has hindered the recovery of threatened spring-run Chinook Salmon Oncorhynchus tshawytscha in Oregon's Willamette River basin. In 2011–2014, we assessed migration mortality for 762 radio-tagged adults along a ~260-km reach of the main stem of the Willamette River. Annual survival of salmon to spawning tributaries ranged from 0.791 (95% CI = 0.741–0.833) to 0.896 (0.856–0.926), confirming concerns about mortality in the migration corridor. In a series of general linear models, descaling, marine mammal injuries, and head injuries to adult Chinook Salmon were linked to reduced survival during migration to tributaries. Many injuries were minor (i.e., epidermal abrasions), which we hypothesize were unlikely to have caused direct mortality but may have increased salmon vulnerability to pathogens or other disease processes. Mortality in the main stem was not significantly associated with salmon body size, energetic status, sex, origin (hatchery, wild), river discharge, or water temperature metrics. The ~10–21% estimates of en route mortality in this study provide an important benchmark for the main stem of the Willamette River. The estimates complement ongoing efforts to quantify mortality of adult Chinook Salmon in Willamette River tributaries and after collection and transport to spawning sites above high-head hydroelectric dams.
Received September 15, 2016; accepted December 1, 2016 Published online March 3, 2017
Identification of novel mutations associated with cycloserine resistance inMycobacterium tuberculosis
Authors: Zhang Shuo , Chen Jiazhen , Cui Peng , Shi Wanliang , Zhang Wenhong , Zhnag Ying 
Published: March 2017

AbstractObjectivesD-cycloserine (DCS) is an important second-line drug used to treat multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. However, the mechanisms of resistance to DCS are not well understood. Here we investigated the molecular basis of DCS resistance using in vitro isolated resistant mutants ofMycobacterium tuberculosis.MethodsM. tuberculosisH37Rv was subjected to mutant selection on 7H11 agar plates containing varying concentrations of DCS. A total of 35 DCS-resistant mutants were isolated and 18 mutants were subjected to whole genome sequencing. The identified mutations associated with DCS resistance were confirmed by PCR-Sanger sequencing.ResultsWe identified mutations in 17 genes that are associated with DCS resistance. Except mutations inalr(rv3423c) which is known to be involved in DCS resistance, 16 new genesrv0059, betP (rv0917), rv0221, rv1403c, rv1683, rv1726, gabD2 (rv1731), rv2749, sugI(rv3331), hisC2(rv3 772), single mutation in 5’ intergenic region ofrv3345candrv1435c,and insertion in 3’ region ofrv0759cwere identified as solo mutations in their respective DCS-resistant mutants. Our findings indicate that the mechanisms of DCS resistance are more complex than previously thought and involve genes participating in different cellular functions such as lipid metabolism, methyltransferase, stress response, and transport proteins.ConclusionsNew mutations in diverse genes associated with DCS are identified, which shed new light on the mechanisms of action and resistance of DCS. Future studies are needed to verify these findings in clinical strains so that molecular detection of DCS resistance for improved treatment of MDR-TB can be developed.
Evolution and Functional Information
Authors: Matlock Matthew K. , Swamidass S. Joshua 
Published: March 2017

Abstract“Functional Information”—estimated from the mutual information of protein sequence alignments—has been proposed as a reliable way of estimating the number of proteins with a specified function and the consequent difficulty of evolving a new function. The fantastic rarity of functional proteins computed by this approach emboldens some to argue that evolution is impossible. Random searches, it seems, would have no hope of finding new functions. Here, we use simulations to demonstrate that sequence alignments are a poor estimate functional information. The mutual information of sequence alignments fantastically underestimates of the true number of functional proteins, because it also is strongly influenced by a family’s history, mutational bias, and selection. Regardless, even if functional information could be reliably calculated, it tells us nothing about the difficulty of evolving new functions, because it does not estimate the distance between a new function and existing functions. The pervasive observation of multifunctional proteins suggests that functions are actually ver close to one another and abundant. Multifunctional proteins would be impossible if the FI argument against evolution were true.
An improved Isomap method for manifold learning
Authors: Qu Taiguo , Cai Zixing 
Published: March 2017

Purpose
Isometric feature mapping (Isomap) is a very popular manifold learning method and is widely used in dimensionality reduction and data visualization. The most time-consuming step in Isomap is to compute the shortest paths between all pairs of data points based on a neighbourhood graph. The classical Isomap (C-Isomap) is very slow, due to the use of Floyd’s algorithm to compute the shortest paths. The purpose of this paper is to speed up Isomap.

Design/methodology/approach
Through theoretical analysis, it is found that the neighbourhood graph in Isomap is sparse. In this case, the Dijkstra’s algorithm with Fibonacci heap (Fib-Dij) is faster than Floyd’s algorithm. In this paper, an improved Isomap method based on Fib-Dij is proposed. By using Fib-Dij to replace Floyd’s algorithm, an improved Isomap method is presented in this paper.

Findings
Using the S-curve, the Swiss-roll, the Frey face database, the mixed national institute of standards and technology database of handwritten digits and a face image database, the performance of the proposed method is compared with C-Isomap, showing the consistency with C-Isomap and marked improvements in terms of the high speed. Simulations also demonstrate that Fib-Dij reduces the computation time of the shortest paths from O(N3) to O(N2lgN).

Research limitations/implications
Due to the limitations of the computer, the sizes of the data sets in this paper are all smaller than 3,000. Therefore, researchers are encouraged to test the proposed algorithm on larger data sets.

Originality/value
The new method based on Fib-Dij can greatly improve the speed of Isomap.
Chaos control of the power system via sliding mode based on fuzzy supervisor
Authors: Sarani Ali Abadi Ahmad , Balochian Saeed 
Published: March 2017

Purpose
The purpose of this paper is to address the problem of control in a typical chaotic power system. Chaotic oscillations cannot only extremely endanger the stabilization of the power system but they can also not be controlled by adding the traditional controllers. So, the sliding mode control based on a fuzzy supervisor can sufficiently ensure perfect tracking and controlling in the presence of uncertainties. Closed-loop stability is proved using the Lyapunov stability theory. The simulation results show the effectiveness of the proposed method in damping chaotic oscillations of the power system, eliminating control signal chattering and also show less control effort in comparison with the methods considered in previous literatures.

Design/methodology/approach
The sliding mode control based on a fuzzy supervisor can sufficiently ensure perfect tracking and controlling in the presence of uncertainties. Closed-loop stability is proved using the Lyapunov stability theory.

Findings
Closed-loop stability is proved using the Lyapunov stability theory. The simulation results show the effectiveness of the proposed method in damping chaotic oscillations of power system, eliminating control signal chattering and also less control effort in comparison with the methods considered in previous literatures.

Originality/value
Main contributions of the paper are as follows: the chaotic behavior of power systems with two uncertainty parameters and tracking reference signal for the control of generator angle and the controller signal are discussed; designing sliding mode control based on a fuzzy supervisor in order to practically implement for the first time; while the generator speed is constant, the proposed controller will enable the power system to go in any desired trajectory for generator angle at first time; stability of the closed-loop sliding mode control based on the fuzzy supervisor system is proved using the Lyapunov stability theory; simulation of the proposed controller shows that the chattering is low control signal.
Cultivating the brand-customer relationship in Facebook fan pages
Authors: Chang Shing-Wan , Fan Shih-Heng 
Published: March 2017

PurposeThe purpose of this paper is to examine the determinants of continuous brand-customer relationship via company-hosted social networking sites (SNSs). Factors that influence fans to continue using fast-fashion brands’ Facebook fan pages and to maintain the brand-customer relationship are discussed first. Subsequently, the predictors of fans’ engagement and affective commitment to a fast-fashion brand are examined with the aim to explore the key elements that nurture the brand-customer relationship via brands’ SNSs.Design/methodology/approachA quantitative research was conducted and the structural equation modelling was used to test the hypotheses on a sample of 202 fast-fashion Facebook fan page users in Taiwan.FindingsThe results demonstrate that engagement, affective commitment and continued intention to use are predominantly influenced by, in turn, social interaction tie, content value and affective commitment.Research limitations/implicationsThe study is limited because it investigated the fast-fashion fan page users in an Asian country, so the findings cannot be generalised to other contexts.Practical implicationsThe findings suggest that fan page managers’ initiation and involvement in conversations, frequent responses, listening to fans’ opinions and improving fans’ experiential value may facilitate them to engage in the brand’s activities at a higher level.Originality/valueThe findings of this integrated model suggest managerial guidelines for brand managers in this industry regarding how to maintain the brand-customer relationship through social media strategy and how they contribute to theory building in continuance intention of SNSs.
Establishing an evidence-based 9D evaluation approach for ERP post-implementation
Authors: Peng Guo Chao , Nunes Miguel 
Published: March 2017

Purpose
The purpose of this paper is to propose a systematic and customisable framework, titled the 9D approach, aiming to evaluate the enterprise resource planning (ERP) systems as well as to identify potential socio-technical problems, misfits and deficiencies that can cause ERP failure during the system post-implementation phase.

Design/methodology/approach
The proposed 9D ERP evaluation framework includes nine dimensions and 85 evaluation criteria. This theoretical framework is then used in a six-step evaluation process based on a mixed-methods design. A case study involving a large-size private company in China was used as an exemplification to illustrate how the proposed 9D approach can be applied in practices.

Findings
The findings of the study clearly demonstrated that after the ERP “go-live” point, companies still experience many challenges and problems in the post-implementation phase. These problems can be located in very diverse organisational, systemic and personnel aspects of the company, as well as across different functional areas and organisational levels. The proposed 9D approach was demonstrated to be an efficient and systematic tool to investigate and explore such ERP problems in an in-depth level within the organisational context.

Research limitations/implications
This study contributes to the theory of IS evaluation in general, and provides valuable insights into the ERP post-implementation evaluation in particular.

Practical implications
The proposed ERP evaluation approach forms a sound base for continuous ERP improvement and contributes to sustain seamless alignment between ERP and its organisational context. The customisable feature of the framework offers flexibility and enables its use by companies of all sizes, any sector, and any country.

Originality/value
To the best of the researchers’ knowledge, this is the most extensive and comprehensive framework for the post-evaluation of ERPs proposed hitherto. The need for this new framework was grounded on the argumentation of the drawbacks of existing ERP measurement and evaluation studies that simply focus on success rather than the more critical failure factors.
A supply chain performance measurement approach using the internet of things
Authors: Dweekat Abdallah Jamal , Hwang Gyusun , Park Jinwoo 
Published: March 2017

PurposeThe purpose of this paper is to introduce a more practical approach for supply chain performance measurement (SCPM) and to approve the promising role of internet of things (IoT) technologies in SCPM systems.Design/methodology/approachThis is a conceptual paper that includes literature review analysis, designing a new approach for SCPM, and a case study scenario for proving its applicability.FindingsThe case study scenario shows that IoT can enhance SCPM, as it has the capability to enable real-time data collection, increase data efficiency as long as enable real-time communication within the supply chain (SC).Practical implicationsThe proposed approach can help to develop performance measurement systems and applications enabled by IoT technologies. These systems can be used to monitor, manage, and control the overall SC in real time and in a more integrated and cooperative manner.Originality/valueThis paper provides a structured systems building approach tailored to show how to employ IoT technologies in the field of SCPM. This approach could help in establishing new performance measurement applications, and it is believed that both practitioners and researchers will benefit from it.
Determinants and outcomes of faculty consulting from management teachers’ perspective
Authors: Chillara Lakshmi Hymavathi , Sahoo Debajani , Ponnam Abhilash 
Published: March 2017

PurposeThe purpose of this paper is to explore the major determinants that influence the management teachers to practice management consulting. The second objective of this research is to understand how the experience in management consultancy leads to value addition in their class room teaching.Design/methodology/approachTo address the first research objective, focus group discussions were conducted with management teachers practicing consultancy. These results were used to generate items for the questionnaire. Factor analysis performed on the data revealed six determinants influencing management teachers to engage in consulting activity. To address the second research objective, focus group discussions with MBA graduates were used to comprehend how teachers with management consulting experience enrich the pedagogy.FindingsThe major findings of the study suggest that the determinants influencing management teachers to practice consulting are: improving competencies, furthering professional advancement, accruing strategic and financial benefit, enabling holistic development. Through study 2, the authors found out that management teachers add value in pedagogy by forging corporate world connection through real-time examples, enable critical thinking by breaking established paradigms, effective classroom delivery through storytelling, etc., and lending student support by assuming a mentor’s role.Practical implicationsThis study found that faculty consulting reduces the perceived gap between the industry and academia and it also leads to effective class room teaching.Originality/valueThe study is the first attempt to empirically test the determinants influencing management teachers to practice consultancy services and qualitatively assess how the consultancy experience enriches the in-class performance.