bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisotropic Hollow Structure with Chemotaxis Enabling Intratumoral Autonomic Therapy
Authors: Hou Ping , Xie Lingeng , Zhang Ludan , Du Xin , Zhao Decai , Wang Yuguang , Yang Nailiang , Wang Dan 
Published: October 2024

AbstractEffective intratumoral drug penetration is pivotal for successful cancer treatment. However, due to the disrupted capillary networks and poor perfusion in solid tumors, there exist challenges to realize autonomous directional drug penetration and controlled drug release within the tumor. Considering the specificity of glucose within tumor tissue, we draw inspiration from nature and engineer asymmetrical hollow structures exhibiting chemotaxis towards high glucose levels. By incorporating multiple shells into these structures, we enhance the local chemical concentration gradients, thereby improving cellular uptake and precise targeting. The advantages of anisotropic hollow multishell structure (a‐HoMS) can be reflected from the diffusion coefficient and directivity, which increase by 73.4 % and 273 % respectively compared to conventional isotropic hollow spheres, achieving the most linear movement while ensuring the speed of movement. Furthermore, the multi‐level porosity and temporal‐spatial order of a‐HoMS enable sequential drug delivery that inhibits angiogenesis with inducing cell apoptosis. After the eradication of localized tumor cells, the a‐HoMS can automatically migrate to the alive tumor cells under the glucose gradient, inducing another cycle of drug delivery and chemotaxis, resulting in excellent antitumor efficacy. These anisotropic HoMS demonstrate intelligence, adaptability, and precision in tumor therapy, providing valuable insights for programmable treatment within tissues.
Selenium Dioxide Catalyzed Polymerization of N‐doped Poly(benzodifurandione) (n‐PBDF) and Its Derivatives
Authors: Liu Guangchao , Hsu Hsuan‐Hao , Samal Sanket , Lee Won‐June , Ke Zhifan , You Liyan , Savoie Brett M. , Mei Jianguo 
Published: October 2024

AbstractThe recent discovery of highly conductive, solution‐processable, n‐doped poly(benzodifurandione) (n‐PBDF) marks a milestone in the development of conducting polymers. Currently, n‐PBDF is prepared by either duroquinone‐mediated or copper‐catalyzed polymerizations, where scalability and cost‐effectiveness may present challenges. Here, we report a general, scalable, and cost‐effective method for n‐PBDF and its derivatives, namely selenium dioxide (SeO2) catalyzed polymerization. We discovered that a catalytic amount of selenium dioxide leads to high monomer conversions (>99 % by NMR). The obtained n‐PBDF exhibits a consistently narrow hydrodynamic diameter distribution and its thin films show high conductivities. Furthermore, we revealed that this polymerization involves a mechanism distinct from the previously reported radical pathway. It involves successive Riley oxidation and aldol polycondensation processes. It was also found that the reduced selenium precipitates from dimethyl sulfoxide (DMSO) when the catalytic cycle is terminated, allowing for a straightforward purification process through centrifugation and filtration. This method thus eliminates the need for the costly and slow dialysis process. Finally, we demonstrated that SeO2 catalyzed polymerization is applicable to n‐PBDF derivatives, proving the generality of this method.
Metal‐Organic Frameworks (MOFs) for Glucose Sensing: Advancing Non‐Invasive Detection Strategies in Diabetes Management
Authors: Blessy Rebecca P. N. , Durgalakshmi D. , Rakkesh R. Ajay 
Published: October 2024

AbstractEffective glucose monitoring is critical for managing diabetes and preventing its associated complications. While commercial glucose monitoring devices predominantly rely on blood samples, emerging research focuses on detecting glucose in alternative biofluids, harnessing advanced nanomaterials. Among these, Metal‐Organic Frameworks (MOFs), composed of metal ions and organic ligands, have garnered significant attention due to their unique properties, including tunable porosity, high surface area, and abundant active sites conducive to glucose interaction. MOFs present a versatile platform for glucose sensing, offering potential in both enzymatic and non‐enzymatic detection methods. This review delves into the recent advancements in MOFs‐based electrochemical glucose sensors, providing a comprehensive analysis of various MOFs and their composites as electrode materials. The discussion highlights the structural attributes, functionalization strategies, and electrochemical performance of MOFs in glucose sensing, emphasizing their role in the development of next‐generation, non‐invasive glucose monitoring technologies. The review provides a comprehensive overview on the application of MOFs and MOFs‐based composites in both enzymatic and non‐enzymatic electrochemical‐based glucose sensing and highlights the synthesis, mechanism, functionalization and development in the detection strategy of MOFs in glucose sensing.
Unraveling the Synergistic Effects of Thiazolidine Co‐Sensitizers in Dye‐Sensitized Solar Cells
Authors: Abu‐Melha Sraa 
Published: October 2024

ABSTRACTDye‐sensitized solar cells (DSSCs) have garnered significant attention as a promising photovoltaic technology because of their low cost and simplicity. However, the development of efficient organic sensitizers remains a challenge. In this study, we report the synthesis and characterization of two novel organic co‐sensitizers, CD‐1 and TD‐2, based on a thiazolidine core structure and the incorporation of carbazole and triphenylamine donor moieties, respectively. Co‐sensitizers were designed to leverage the strong electron‐donating abilities of these donors to facilitate efficient light‐harvesting and charge‐transfer processes. In‐depth analyses of the spectroscopic and electrochemical properties provided insights into the characteristics of TD‐2 compared with those of CD‐1. TD‐2 displayed a wider range of absorption wavelengths, a narrower energy gap (2.19 eV), and a higher energy level for its (HOMO) than that of CD‐1. These distinctions are attributed to the enhanced capacity of TD‐2 to donate electrons and the elongated π‐conjugation of the triphenylamine component. Upon sensitization, the TD‐2 scored efficiency reached 5.10% and co‐sensitized with N719 dye achieved the highest efficiency, reaching 7.95%. Both sensitizers increased the efficiency of N719 by co‐sensitization (TD‐2 + N719), with an efficiency higher than 15% compared with N719.
Pea Pod–Derived Biochar–Zeolitic Imidazolate Framework Composite for the Photocatalytic Degradation of Two Organic Dyes Crystal Violet and Victoria Blue
Authors: Darabdhara Jnyanashree , Roy Saptarshi , Ahmaruzzaman Md. 
Published: October 2024

ABSTRACTThe rapid increase of water pollution globally is a vital environmental concern that requires the immediate attention of researchers to find new innovative ways to remove unwanted environmental pollutants from our water sources. With the advances in the field of sustainable engineering, there is a high demand for the effective utilization of biomass resources for the removal of aqueous environmental contaminants. Biochar is carbon carbon‐enriched substance obtained by biomass pyrolysis; it is inexpensive and has received wide attention in the field of wastewater treatment. Herein, we describe the synthesis of pea pod (PO) biochar‐reinforced zeolitic imidazolate framework (ZIF‐8) nanocomposite (PO@ZIF‐8) through the in situ precipitation of ZIF‐8 onto the biochar surface. The crystal growth, morphology, chemical composition, and optical characteristics of fabricated PO@ZIF‐8 nanocomposite were scrutinized through PXRD, SEM, TEM, UV‐DRS, PL, and XPS analysis. The dodecahedral‐shaped PO@ZIF‐8 particles have an average size between 140 and 160 nm. The biochar‐reinforced ZIF‐8 nanocomposite showed significantly higher photocatalytic activity than the pure ZIF‐8 for the degradation of two commonly found organic dyes crystal violet (CV) and Victoria Blue (VB) in the presence of direct sunlight irradiation. The PO@ZIF‐8 nanocomposite showed the highest degradation efficiency of ~87% and ~80% within 50 min of irradiation time at a catalyst dosage of 20 mg for 30 ppm CV and VB dye solutions at pH 8. First‐order kinetics were obeyed during the photodegradation with 0.041 and 0.030 min−1 as the constant of degradation for the removal of CV and VB. The radical scavenger experiment and the photoluminescence analysis confirm the active participation of ·OH radical in the degradation of both dyes. LC–MS and TOC analysis was also performed to determine the degradation products and for evaluation of the degradation progress. Moreover, the synthesized PO@ZIF‐8 composite also exhibit good stability till the fourth cycle with high degradation efficiency thus making it a good choice of catalyst in the field of environmental decontamination.
The effect of NaY‐zeolite on mechanical, thermal, and spectroscopic behavior of crosslinked polyvinyl alcohol films
Authors: Bozdoğan Altan 
Published: October 2024

AbstractThe effects of sodium y zeolite (NaY‐zeolite) on crosslinked Polyvinyl alcohol (CrPVA) composite films were investigated. The spectroscopic analysis showed that crosslinks were formed between PVA, Tartaric acid (TA), and NaY‐zeolite particles. The thermal stability of the CrPVA film was improved with the addition of zeolite. Optimum thermal stability was observed for 5 wt % zeolite content. It can be seen that the mechanical properties also improved for 5 wt % zeolite‐doped CrPVA composite films when compared with CrPVA. It was observed that Young's modulus increased 54.14 to 74.49 MPa. While the degree of crystallinity of the composite film decreased from 20.42 to 14.77% due to zeolite content. This is thought to be due to the increase in the structure's crosslinking rate. The utilization of TA and NaY zeolite in membrane applications may be considered an advantage for improving the mechanical characteristics and the recyclability of membrane technology.
Preparation and study of attapulgite reinforced PVA fiber with cross‐linking of boric acid
Authors: Hong Xinqiu , Li Haifeng 
Published: October 2024

AbstractPolyvinyl alcohol (PVA) fibers were manufactured by gel spinning with reinforcing of attapulgite (ATT) and cross‐linking of boric acid (PVA/B/ATT fibers), in order to improve the mechanical properties. Furthermore, the final fibers were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectra (FTIR), differential scanning calorimetry (DSC), thermogravimetric analyzer (TGA), powder x‐ray diffraction (XRD) and tensile strength tester. In addition, when ATT amount was no more than 2.0 wt%, FTIR analyses suggested that the degrees of cooperation combining of ATT and boric acid with PVA macromolecules were enhanced. SEM images indicated that PVA/B/ATT fibers had smooth surfaces. DSC, TGA and XRD results illustrated that the melting temperatures and maximum thermal decomposition temperatures first increased and then dropped as the content of ATT increased. Moreover, mechanical properties results indicated that the optimal ATT amount was 2.0 wt%, and the tensile strength of PVA/B/ATT‐2 fiber reached the highest of 14.2 ± 0.3 cN/dtex. It was largely because that the cooperation combining of boric acid and ATT with PVA molecules improved the mechanical properties of PVA/B/ATT fibers.
An overview on olfaction in the biological, analytical, computational, and machine learning fields
Authors: Chiera Federica , Costa Giosuè , Alcaro Stefano , Artese Anna 
Published: October 2024

AbstractRecently, the comprehension of odor perception has advanced, unveiling the mysteries of the molecular receptors within the nasal passages and the intricate mechanisms governing signal transmission between these receptors, the olfactory bulb, and the brain. This review provides a comprehensive panorama of odors, encompassing various topics ranging from the structural and molecular underpinnings of odorous substances to the physiological intricacies of olfactory perception. It extends to elucidate the analytical methods used for their identification and explores the frontiers of computational methodologies.
Advancements in synergistic fermentation of probiotics and enzymes for non‐grain feed raw materials
Authors: Deng Xiangrong , Chen Kai , Jiang Dahai , Lu Liming 
Published: October 2024

AbstractTo address the escalating challenge of food scarcity and the associated conflicts between human and animal consumption, it is imperative to seek alternative resources that can substitute for traditional feed. Non‐grain feed (NGF) raw materials represent a category of biomass resources that are distinct from grains in their composition. These materials are characterized by their high nutritional content, cost‐effectiveness, ample availability, and consistent supply, which contribute to their significant economic potential. Nonetheless, the extensive application of NGF is currently hindered by several limitations, including a high concentration of antinutritional factors, suboptimal palatability, and an offensive odor, among other shortcomings. The synergistic fermentation of probiotics and enzymes (SFPE) is an innovative approach that integrates the use of a diverse array of enzymes during the feed fermentation process, as well as various strains of probiotics throughout the feed digestion process. This method aims to enhance the nutritional value of the feed, diminish the presence of antinutritional factors, and improve the overall palatability, thereby facilitating the optimal utilization of NGF. This strategy holds the promise of not only replacing conventional feed options but also mitigating the pressing issue of grain scarcity. This paper delves into the practical applications of NGF and presents an overview of the latest research advancements in SFPE fermentation techniques, which can provide cutting‐edge and valuable reference for researchers who devote themselves to research in this field in the future.
Site‐Selective Direct γ‐Difunctionalization of Diazoenals: Application to the Synthesis of Enal‐Functionalized Allenes and Furans
Authors: Kalepu Jagadeesh , Sudam Lad Bapurao , Kumar Mandal Pratap , Kanchupalli Vinaykumar , Roy Durjay , Katukojvala Sreenivas 
Published: October 2024

AbstractA new approach for the synthetically important γ‐functionalized enals has been developed. The strategy involves rhodium‐catalyzed direct C−C & C−S bond forming site‐selective γ‐difunctionalization of diazoenals with aryl propargyl sulfides via sulfur ylide [2,3] sigmatropic rearrangement, resulting in the highly functionalized γ‐allenyl(sulfanyl)enals in excellent yield at ambient temperature. This highly versatile approach constitutes a viable alternative to the remote carbonyl‐directed γ‐functionalization of unmodified enals which suffer from competitive side reactions. The synthetic utility of the γ‐allenyl(sulfanyl)enals was demonstrated by the InCl3‐catalyzed cycloisomerization to the trisubstituted furanyl‐enals via an unusual 1,4‐sulfanyl migration. In addition, an operationally simple and efficient one‐pot [3+2] annulation of diazoenals and propargyl sulfides, involving combined γ‐difunctionalization and cycloisomerization was successfully developed for the diverse enal‐functionalized furans.
The Role of Spacers as a Probe in Variation of Photoluminescence Properties of Mono‐ and Bi‐Nuclear Boron Compounds
Authors: Kumar Yadav Rahul , Parveen Darakshan , Mondal Bijan , Kumar Roy Dipak 
Published: October 2024

AbstractA series of N,O donor‐based mono‐ and binuclear four‐coordinated boron complexes were synthesized. Depending on the substitution and spacer, these complexes exhibit intense blue, green and yellow emission in solution states. Notably, the fluorescence quantum yields (ΦF) and fluorescence decay (lifetime, τ) of mononuclear boron complexes (2 a–2 e) were higher than the binuclear boron complexes (2 f–2 k). The lowest lifetime and quantum yield in binuclear boron complexes were due to intramolecular rotation induced non radiative processes. The disulphide spacer‐based boron complexes 2 i–2 k showed aggregation‐caused quenching in the THF/H2O mixture whereas no other complexes were ACQ responsive. These complexes show large Stokes shift, one of them i. e. 2 e has the highest Stokes shift of 130 nm. Further, the electrochemical study suggests the presence of two redox incidences. Theoretical studies show close corroboration between the TD‐DFT computed and experimentally measured absorption maxima as well as DFT (GIAO) calculated and experimentally measured 11B NMR values. This complements the appropriate selection of the theoretical methods to shed light on the electronic transitions in the mono‐ and binuclear BF2 complexes.
A sustainable and expedited ‘One‐Stop’ prostate cancer diagnostic pathway to reduce environmental impact and enhance accessibility
Authors: Storino Ramacciotti Lorenzo , Kaneko Masatomo , Rodler Severin , Mohideen Muneeb , Cai Jie , Liang Gangning , Aron Manju , Hopstone Michelle , Stern Mariana C. , Cacciamani Giovanni E. , Gill Inderbir , Abreu Andre Luis 
Published: October 2024

AbstractObjectiveTo assess the carbon footprint, accessibility, and diagnostic performance of an expedited ‘One‐Stop’ prostate cancer (PCa) diagnostic pathway.Materials and methodsA total of 1083 consecutive patients undergoing magnetic resonance imaging (MRI) followed by transrectal ultrasound fusion‐guided prostate biopsy (PBx) were identified from a prospective database. The patients were divided according to the diagnostic pathway: One‐Stop, with MRI and same‐day PBx (3 hours apart), or Standard, with MRI followed by a second visit for PBx. Socioeconomic status was evaluated by the Distressed Communities Index (DCI) and the carbon footprint by the United States (U.S.) Environmental Protection Agency Greenhouse Gases Equivalencies Calculator.ResultsOverall, 260 patients underwent the One‐Stop and 823 the Standard pathway. The One‐Stop patients lived farther from the hospital (163 vs. 23 km; p < 0.001), had lower socioeconomic status with DCI scores of 49 versus 30 (p < 0.001), and were more likely to be Latinos (21% vs. 13%, p < 0.001) compared to the Standard patients, respectively. The One‐Stop saved 69 575 km in round trips, over 16 tons of travel‐related CO2 emissions, and $8214 U.S. dollars. For patients with Prostate Imaging Reporting & Data System (PIRADS) 3–5, the clinically significant PCa detection (53% vs. 50%, p = 0.55) was similar for the One‐Stop and Standard pathways, respectively.ConclusionsThe One‐Stop PCa diagnostic pathway reduces carbon footprint, distance travelled, and patient‐level cost while maintaining clinical outcomes comparable to the Standard pathway. It facilitates access to tertiary‐level care for minorities and underserved populations.
Analysis of pharmacological effects and mechanisms of compound essential oils via GC–MS and network pharmacology
Authors: Wu Dong , Li Mengchu , Gong Jianping , Huang Wenping , Zeng Wenhui , Jiang Ying 
Published: October 2024

AbstractAromatherapy based on essential oil (EO) has been widely used for alleviating pain and intense where no compound EO reports its application on pharmacological effects. In order to explore the active pharmaceutical ingredients (API) and mechanism of a compound EO, a blend of Artemisia argyi, Boswellia carterii, Commiphora myrrha, Cinnamomum cassia, Zingiber oj‐jicinale, and Ilex pubescens EO, in treating neck and shoulder pain (NSP). Network pharmacology hyphenated with mice model was employed to investigate. Gas chromatography–mass spectrometry (GC–MS) was applied for the identification of constituents in compound EO. Lastly, transdermal absorption of compound EO was studied before verifying analgesic and anti‐inflammatory effects in mice. Totally, 75 compounds were tentatively identified through GC–MS, predicting 46 potential analgesic targets. Moreover, 11 core targets were obtained through network topology screening. Animal test resulted that the compound EO had significantly stronger anti‐inflammatory and analgesic effects compared to single EO. Multiple API in compound EO affected on targets and exerted therapeutic effects on NSP through multiple pathways. Afterwards, eucalyptol, camphor, and borneol from compound EO exhibited a sustained‐release effect, which provide scientific basis to illustrate the application of compound EO in clinical.
The effect of board of directors attributes, environmental committee and institutional ownership on carbon disclosure quality
Authors: Abdelrahman Adam Abdalla Abbas , Salleh Zalailah , Hashim Hafiza Aishah , Wan Zakaria Wan Zuriati , Al‐ahdal Waleed M. 
Published: October 2024

AbstractThis study assesses the effect of the board of directors' attributes, environmental committee (EC), and institutional ownership (IO) on carbon disclosure quality (CDQ) from the perspectives of legitimacy and agency theories in Malaysia. This study collects and analyzes data based on 1000 observations of firms from carbon‐intensive industries from 2015 to 2019. The effect of the board of directors' attributes, EC, and IO on the CDQ was observed using a panel data regression model. The study revealed a significant positive relationship between board independence, board size, female representation, EC, IO, and CDQ. These findings suggest that carbon disclosure awareness is rising in Malaysia as firms have gradually integrated corporate governance (CG) best practices into their business strategies. To the best of our knowledge, this is the first study to examine the factors that influence CDQ in Malaysian businesses. This study identified firms with a higher CDQ using a new global reporting initiative‐based carbon reporting index. This expands the literature on carbon disclosures. This study focuses on carbon‐intensive industries, which might not reflect Malaysia's current CDQ situation. Thus, future research should focus on other sectors to fully grasp the current state of the CDQ in Malaysia and offer new perspectives on emerging markets. The findings may benefit a vast group of regulatory bodies in assessing Malaysian firms' responses to local and international carbon guidelines.
How do aspirations work? Financial performance shortfalls and firms' green innovation
Authors: Zhao Jing , Cheng Xiyun , Guo Jintong 
Published: October 2024

AbstractResearch on the behavioral theory of the firm (BTOF) highlights the role of performance shortfalls in managers' decision process. However, previous studies tend to ignore the heterogeneity of historical and social aspirations. This paper investigates how firms' green innovation, a typical environmental behavior, differently responds to financial performance shortfalls relative to historical and social aspirations. Based on the view of problemistic search, we argue and find that financial performance shortfalls derived from historical aspiration impair green innovation, whereas financial performance shortfalls derived from social aspiration first reduce and then promote green innovation, demonstrating a U‐shaped relationship. Moreover, we find that the two aspirations may interact to influence green innovation activities. Specifically, the negative effect of performance shortfalls (historical) is more pronounced when the financial performance is below social aspiration, whereas the U‐shaped effect is flattened if the financial performance is at or above historical aspiration. Further, we explore how the effects vary with financial constraints and manager overconfidence to distinguish the underlying mechanisms. Our study extends a nascent understanding of aspiration heterogeneity by revealing firms' different green innovation strategies in response to different aspirations.