bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilidad clínica de la hemoglobina reticulocitaria equivalente en pacientes en hemodialisis crónica
Authors: Eckhardt Andrea , Freiberg M. , De la Fuente Jorge Luis , Douthat Walter G. , Capra Raúl Horacio 
Published: September 2024

Background. Iron deficiency is the main cause of failure to respond to erythropoietin (EPO) in haemodialysis patients. Several laboratory tests to detect the deficiency, ferritin and transferrin saturation (TSat) are the most commonly used but its limitations in this patient population are necessary to find other parameters to improve the identification of iron-deficient state. Objective. To evaluate the ability of Reticulocyte Hemoglobin Equivalent (RET-He) to predict iron deficiency, taking as a reference standard to the increase of hemoglobin in response to iron intake. Materials and Methods. 44 patients on chronic hemodialysis and fixed-dose EPO received 400 mg of intravenous iron. Were measured Hb, Ret-He, IRF, and ferritin prior to iron administration. After 20 to 30 days of completion of loading the patients were classified as responders if hemoglobin increased by at least 0.8 g / L and non-responders if this increase did not occur. Result. 25 patients were reponders, the ROC curves analysis showed the Ret-He with the largest AUC of 0.862 similar to the AUC of 0.833 that showed the IST, but the first is more sensitive (72% CI 95%: 51-88% vs 52% 95% CI 31-72%) and similar specificity (94.7% CI 95%: 74-100% vs 100% 95% CI 82-100%). Ferritin AUC was 0.772 and finally the IRF AUC was 0.7. The Ret-He, to a cutoff of 29.5 pg was the best combination of sensitivity and specificity (72 and 94.7 respectively), and the sensitivity of the combination Ret-He/IST rose to 80% specificity 94.7%. Conclusions. According to these results it could consider to Ret-He and the Ret-He/IST combination of clinical utility for the identification of the iron deficit in patients in chronic haemodialysis.
Evaluación comparativa de eficacia y tolerancia de hierro sulfato y hierro polimaltosato para el tratamiento de anemia ferropenica en lactantes
Authors: Amaral Diego , Galimberti Griselda , Cuesta Soledad , Pinto Juana , Ferrario Claudia , Graciela Elena 
Published: September 2024

Introduction: Iron deficiency anemia is the most common nutritional deficiency in children under 2 years, affecting to 34.1% in Argentina. Iron supplementation is the standard treatment. The aim of our study was to evaluate the efficacy and tolerability of two iron containing drugs. Methods: Randomized, double-blind, controlled trial, including children aged 6 to 18 months with iron deficiency anemia (hemoglobin < 11 g/dl, transferrine saturation < 20%). Patients were randomly assigned to one of two treatments: iron polymaltose complex (IPC) or ferrous sulphate (FS). Efficacy, tolerance and adverse events occurrence were evaluated. Results: 60 children with iron deficiency anemia were included; 29 in the FS group and 31 in the IPC group. There were no significant differences between groups regarding hemoglobin at baseline (10,09 ± 0,92 vs. 10,26 ± 0,41; p= 0,17) and after 90 days treatment (11,26 ± 0,49 vs. 11,14 ± 0,60; p= 0,21).Also, there were no differences regarding adverse events frequency (FS: 4/29 y IPC: 9/31; p=0,2). Conclusions: In our study, there were no differences in efficacy and safety between FS and IPC in the treatment of children with iron deficiency anemia.
Efecto de la altitud sobre el peso al nacer y eventos perinatales adversos en dos poblaciones argentinas
Authors: Grandi Carlos , Dipierri José , Luchtenberg Guillermo , Moresco Angélica , Alfaro Emma 
Published: September 2024

Introduction: Depending on the geographical altitude the purpose of this work was to analyze in two argentine populations the variation of birth weight (BW) and adverse perinatal outcomes, adjusting for maternal and obstetric factors.Material and Methods: Data from 4000 births in the provinces of Jujuy and 4000 in Buenos Aires (Sarda Maternity Hospital) (1996-2000) recruited and randomized from the Perinatal Information System was used. The data were grouped according to an altitudinal gradient composed by Sarda Maternity (20 masl) and the geographic regions of Jujuy province: Ramal (500 masl), Valle (1200 masl), Quebrada (2500 masl) and Puna (3500 masl). Outcome variables were BW > 3000 g, BW <2500 g, ponderal index (PI), prematurity, small for gestational age (SGA) and intrauterine growth restriction (FGR), while potentially confounding variables were: age, type of partner, education, overweight, obesity, smoking, hypertension, preeclampsia, urinary infection, growth restriction and cesarean section.Results: An increasing altitudinal gradient for adolescent mothers (<19years) and decreasing for the rest of the maternal obstetric variables was observed. The BW, BW>3000 g, BW<2500g and PI were negatively associated with altitude (p <0.001). Prematurity, SGA and FGR showed an opposite trend (p <0.001). Adjusted for confounding variables BW <3000 g, SGA, FGR<0.90 and PI <2.53 showed an increased risk with geographical altitude (p <0.05).Conclusions: Altitude was independently associated with BW restriction and adverse perinatal outcomes. Given the impact of BW reduction in the risk of chronic no communicable diseases this relationship in other populations, regardless of their location altitude, should be assess.
Predictores de coqueluche al ingreso en lactantes hospitalizados con infección respiratoria aguda baja
Authors: Laura Moreno , Montanaro Patricia , Bujedo Elizabeth , Cámara Jorge , Abilar C. , Terzoni M. , Romano M. , Inés Marqués , Quiroga Daniel , Orecchini Alejandra , Jacome Javier , Ferrero Fernando 
Published: September 2024

Background. Pertussis, or whooping cough, caused by Bordetella pertussis (BP) is a re-emerging problem in our environment. Although generally considered that the disease is relatively easy to identify infections respiratory syncytial virus (RSV) can present with similar symptoms in infants remains difficult discrimination.Objective. Compare clinical symptoms at admission and complementary studies in infants hospitalized with acute respiratory infection (ARI) and RSV by BP to establish markers that enable their early clinical prediction.Materials and methods. Observational, analytical, case-crossover cross comparing younger than 6 months hospitalized with suspected IRA and pertussis (2007-2012) in which BP identified (PCR and culture) and / or VRS (immunofluorescence in nasal secretions). Coinfections were excluded. Bivariate analysis was comparaperformed by calculating OR with 95% CI. Were considered significant at p <0.05. The variables studied were age, sex, hits cough, cyanosis, vomiting, apnea, wheezing and CBC with differential.Results. We included 174 infants, 72 (41%) BP and 102 (59%) VRS. Age 2 ± 1 months (range :1-6). In both groups was documented cough and wheeze (OR: 1.2 (0.9 to 1.5) p: 0.1 and OR = 0.9 (0.8 to 1.06) p: 0.2, respectively ). Cyanosis (87% vs. 6%, OR: 14.8 p <0.01), apnea (38% vs. 3%, OR: 13.4 p <0.01) and vomiting (26% vs. 5% , OR: 3.4 p <0.01) were more frequent in infants with BP. The absolute lymphocyte count was significantly higher in children with BP (9387 ± 6317 vs. 5127 ± 2766, p <0.01). By ROC curve was identified at 9000 cells / ml as the best point to differentiate VSR BP (AUC = 0.73, 95% CI :0,64-0, 81).Conclusions. In infants under 6 months with IRA income presence of apnea, cyanosis and lymphocytosis allowing predict significantly differentiate between pertussis those with RSV infections.
Aporte de leche materna en el recién nacido prematuro hospitalizado y evolución nutricional
Authors: Arguello Carolina E , Defagó María Daniela 
Published: September 2024

ResumenAntecedentes: El nacimiento pretérmino es una emergencia nutricional y requiere consideraciones especiales. Objetivos: Se propuso evaluar el aporte de leche humana (LH) en el recién nacido prematuro hospitalizado de bajo peso (RNP-BP) y muy bajo peso (RNP-MBP), factores maternos y su relación con parámetros nutricionales. Materiales y métodos: Participaron 87 RNP-BP y 82 RNP-MBP admitidos en un hospital público en Córdoba, Argentina. Se registró la antropometría evolutiva, alimentación, parámetros bioquímicos, antecedentes del niño y maternos. Se calculó el aporte de LH. Se analizaron los valores antropométricos y bioquímicos, días de internación y factores maternos según aporte de LH. Resultados: El 36,36% de los RNP-MBP y el 31,02% de los RNP-BP cubrió más del 20% de su alimentación con LH. La hemoglobina sérica fue superior en RNP-MBP que recibieron más LH (p=0,01). Los RNP con menos del 20% de su alimentación con LH presentaron una asociación estadísticamente significativa entre la cantidad de LH y la talla al alta hospitalaria. Se observó una elevada prevalencia de cesáreas, asociada a un menor aporte de LH.Conclusiones: El aporte de LH contribuiría a estabilizar la hemoglobina en RNP. La presencia de cesárea podría asociarse a un menor aporte de LH a los RNP. AbstractBackground: Preterm infants require special considerations than term infants to obtain adequate growth.Objective: The aim was to evaluate human milk (HM) in low birth weight premature newborn (LBW-PN) and very low birth weight (VLBW-PN) during hospitalization, maternal factors, and the relationship with nutritional parameters.Material and methods: 87 LBW-PN and 82 VLBW-PN), admitted in a public hospital in Córdoba, Argentina, were included. Anthropometry, food and biochemical parameters, and child and maternal history were registered. HM contribution was calculated. Anthropometric and biochemical values, days of hospitalization and maternal factors by HM intake were analyzed. Results: Only 36,36% of VLBW-PN and 31,02% of LBW-PN had more than 20% of their diet with HM. The hemoglobin concentration at discharge was higher in VLBW-PN group with more HM (p=0,01). There was a statistically significant association between HM amount and height at discharge in the PN with less than 20% of their diet with HM. A high prevalence of cesarean delivery was observed, related to lower HM.Conclusions: HM contributes to hemoglobin stabilization. Cesarean delivery may be associated with lower contribution of HM to newborn infants.
Tiroidectomía total en el bocio multinodular benigno
Authors: Palas Cesar , Alvarez Facundo , Ferreira Gaston , Gramática Luis 
Published: September 2024

Resumen Introducción. El tratamiento del bocio multinodular beningo (BMNB) es motivo de continuo debate en las últimas décadas pese a la evidencia de que la tiroidectomía total (TT) está relacionada a una reducción significativa en la recurrencia de la enfermedad y a una mínima morbilidad en manos entrenadas. Objetivo. Determinar la recurrencia del BMNB al cabo de 10 años en 100 pacientes tratados con TT y evaluar las complicaciones relacionadas a la técnica. Diseño. Prospectivo no randomizado. Material y métodos. Desde marzo del 1999 a marzo del 2001, cien pacientes, 95 del sexo femenino, con un promedio de edad de 42,4 años (rango: 23-67), fueron sometidos a una TT por padecer un BMNB, el cual fue confirmado por la ecografía cervical, la que además sirvió de guía para realizar la punción aspiración con aguja fina (PAAF). En todos los casos se realizó un laringoscopía inderecta pre y post postquirúrgica. Resultados. El tiempo operatorio promedio fue de 49 minutos (rango: 35-58). Registramos una parálisis recurrencial (1%) y cinco hipoparatiroidismos (5%), ambos transitorios y ningún caso definitivo. Todos los pacientes fueron dados de alta antes de las 24 horas de la cirugía. No objetivamos ninguna recurrencia del BMNB en un período de seguimiento de más de 10 años. Conclusión. La TT es el tratamiento elección del BMNB, por ser un procedimiento eficaz, seguro, con mínimas tasas de complicaciones y por evitar o reducir significativamente la recurrencia de esta enfermedad. Summary Introduction. The treatment of benign multinodular goiter (BMNB) is a matter of ongoing debate in recent decades despite evidence that total thyroidectomy (TT) is associated with a significant reduction in disease recurrence and minimal morbidity in trained hands. Objective. Determine BMNB recurrence after 10 years in 100 patients treated with TT and evaluate the technique-related complications. Design. Prospective non randomized. Material and methods. From March 1999 to March 2001, one hundred patients, 95 female, with an average age of 42.4 years (range 23-67) underwent TT for having a BMNB, which was confirmed by cervical ultrasound, which also served as a guide to perform fine-needle aspiration (FNA). In all cases, laryngoscopy was performed before and after post-surgical bitstream. Results. Mean operative time was 49 minutes (range 35-58). Recurrencial recorded paralysis (1%) and five hypoparathyroidism (5%), both transient and no definitive case. All patients were discharged within 24 hours of surgery. We did not record any recurrence BMNB a follow-up period of more than 10 years. Conclusion. The TT is the treatment choice of BMNB, being an effective, safe, with low rates of complications and to avoid or significantly reduce the recurrence of this disease.
Mecanismos moleculares en metaplasia osteocartilaginosa vascular: revisión sistemática
Authors: Rosero Salazar Doris Haydee 
Published: September 2024

Introducción: Las metaplasias cartilaginosas y óseas que ocurren tanto en el corazón como en los vasos sanguíneos, son consecuencia de factores de riesgo o enfermedades crónicas que gradualmente afectan negativamente el desempeño de una persona en la sociedad y que corresponden a signos clínicos reversibles en estadíos tempranos o intermedios de las alteraciones. Objetivo: Establecer la manera en que los mecanismos moleculares fundamentan los crecientes cambios metaplásicos vasculares y los posibles aspectos de tratamiento y prevención. Materiales y métodos: Se realizó una revisión sistemática mediante la búsqueda de artículos indexados en las bases de datos PubMed, Scopus y Science Direct entre 1995 a 2015. Los descriptores MeSH utilizados fueron metaplasia and vascular calcification, a los que se asociaron los términos de molecular mechanisms, condrogenic and osteogenic. Resultados y discusión: Múltiples factores influyen en el cambio metaplásico, en especial los pro-inflamatorios asociados a la oxidación vascular y la presencia de radicales libres, cuyo desarrollo es reversible mediante el tratamiento con antioxidantes y las modificaciones en el estilo de vida, así como la prevención secundaria al existir un diagnóstico de enfermedad crónica degenerativa. Conclusión: La literatura evidencia que los factores que reduzcan el estrés oxidativo tisular y que promuevan el mantenimiento del fenotipo vascular son protectores y/o reductores de las formaciones metaplásicas osteocartilaginosas.
Evaluación del Insomnio como Factor de Riesgo para Suicidio
Authors: Escobar-Córdoba Franklin , Quijano-Serrano Margarita , Quijano-Serrano Margarita , Calvo-González José Manuel , Calvo-González José Manuel 
Published: September 2024

Resumen Objetivo: realizar una revisión no sistemática de la literatura para describir la relación entre insomnio y suicidio y los hallazgos de dichos estudios.Método: se realizó una búsqueda en las bases de datos PubMed, Medline, SciELO, LILACS, OVID y Cochrane Library combinando los términos MESH: “Suicide AND sleep initiation and maintenance disorders”.Resultados: el insomnio se ha asociado a ideas suicidas, intentos y muertes por suicidio en estudios poblacionales desde hace varios años. El suicidio es una de las principales causas de muerte en el mundo.Discusión: Existen varios factores de riesgo para suicidio; algunos no son modificables, como la edad, el género masculino y etnicidad caucásica. Otros potencialmente modificables como síntomas de depresión, abuso de sustancias y alteraciones del sueño. Entre dichas perturbaciones, el insomnio ha sido el síntoma más comúnmente asociado al suicidio. De hecho se ha considerado que el insomnio es el predictor más potente de intentos de suicidio letales que la existencia misma de un plan específico para cometer suicidio.Conclusiones: Se destaca la importancia para los médicos de detectar y evaluar con detenimiento el insomnio como un signo de alarma y factor de riesgo para suicidio, sin importar, el motivo de consulta de los pacientes.
Hypovitaminosis D in patients with type 2 diabetes
Authors: Ramírez Stieben Luis Agustín , Dobry Raquel , Anca Lilian , González Adrián , López María Isabel , Bayo Salvador , Sánchez Ariel , Brance María Lorena 
Published: September 2024

Introduction. Several studies reported than vitamin D deficiency increases the risk of macrovascular and microvascular disease in patients with type 2 diabetes (T2DM). We investigated the plasma levels of 25OHD in adult patients T2DM, risk factors for 25OHD deficiency and the relationship between 25OHD, glycemic control and chronic complications of T2DM.
Methods. A cross-sectional study was carried out, in which 25OHD levels were evaluated in adult patients (over 18 years) with T2DM. Correlation analyses were performed to evaluate the interdependence of the 25OHD with other continuous variables. A receiver operating characteristic analysis was also performed to identify cutoff values for diagnosing vitamin D deficiency. Logistic regression was performed to identify the independent association between vitamin D deficiency and the variables associated with lower 25OHD.
Results. 208 patients were analyzed. The mean age of the patients was 62 years. The 25OHD level was 19 ng/ml (IQR 13.28-24.43), 59.78% had vitamin D deficiency, and 10.33% had severe deficiency. Glycemia, HbA1c, and BMI were negatively correlated with 25OHD. Cutoff point for vitamin D deficiency was 33.39 kg/m2 for body mass index (BMI), 123 mg/dl for glycemia, and 6.65% for HbA1c. In multivariate logistic regression, BMI>33.39 kg/m2, glycemia >123.5 mg/dl, and albuminuria presented higher odds of vitamin D deficiency.
Major conclusion. Vitamin D deficiency was highly prevalent among patients with T2DM. Low levels were related to higher fasting plasma glucose, higher BMI, and diabetic nephropathy.
APLIKASI MANAJEMEN KENAIKAN GAJI BERKALA, CUTI DAN PENSIUN PEGAWAI PADA BADAN PENDAPATAN DAERAH PROVINSI KALIMANTAN SELATAN BERBASIS WEB
Authors: Weny Niken Anjar , Muin Agus Alim , Setiadi Budi 
Published: September 2024

Badan Pendapatan Daerah Provinsi Kalimantan Selatan merupakan lembaga teknis yang bertanggung jawab dalam pengelolaan pendapatan daerah, termasuk pemungutan pajak, retribusi, dan pengelolaan dana transfer daerah. Dengan struktur organisasi yang terdiri dari satu bagian, dua sub bagian, dan tiga bidang, badan ini memainkan peran krusial dalam mendukung keuangan daerah. Namun, observasi menunjukkan bahwa manajemen data kepegawaian, seperti kenaikan gaji berkala, cuti, dan pensiun, masih dilakukan secara manual, yang berdampak pada efektivitas dan efisiensi kerja. Dalam upaya meningkatkan efisiensi kerja, dikembangkan sebuah sistem berbasis website yang mengotomatisasi pengelolaan data kepegawaian. Aplikasi manajemen kenaikan gaji berkala, cuti dan pensiun pegawai ini berbasis multiuser, dan menggunakan framework laravel. Pengujian aplikasi menggunakan metode blackbox testing. Sistem ini dirancang untuk menggantikan proses manual yang rentan terhadap kesalahan dan kehilangan data akibat masalah teknis. Aplikasi "Manajemen Kenaikan Gaji Berkala, Cuti, dan Pensiun Pegawai pada Badan Pendapatan Daerah Provinsi Kalimantan Selatan" diharapkan mampu mempermudah proses manajemen kepegawaian, serta meningkatkan efektivitas dan efisiensi operasional.
APLIKASI HOTEL BERBASIS WEB PADA DISBUDPORAPAR (DINAS KEBUDAYAAN, KEPEMUDAAN, OLAHRAGA dan PARIWISATA) KOTA BANJARMASIN
Authors: Dicky Putra Mahendra Muhammad , Maulani Jauhari , Wathani Muhammad Rais 
Published: September 2024

Dinas Kebudayaan, Kepemudaan, Olahraga dan Pariwisata Kota Banjarmasin merupakan salah satu Perangkat Daerah yang menyelenggarakan urusan pemerintahan dalam bidang kebudayaan, Kepemudaan, Olahraga dan Pariwisata. Namun, proses pengelolaan dan pencatatan data hotel pada bidang pariwisata saat ini masih dilakukan secara manual menggunakan perangkat lunak seperti Microsoft Excel, Microsoft Word, yang dapat menyebabkan inefiensi dan risiko kehilangan data. Penelitian ini bertujuan untuk mengembangkan Aplikasi Hotel Berbasis Web yang dapat meningkatkan efisiensi dan efektivitas dalam pengelolaan data dan pembuatan laporan. Metode pengembangan perangkat lunak yang digunakan adalah model waterfall, yang meliputi tahap analisis kebutuhan, desain sistem, implementasi, integrasi dan pengujian, serta operasi dan pemeliharaan. Pengumpulan data dilakukan melalui wawancara, observasi, dokumentasi.Hasil dari penelitian ini menunjukkan bahwa dengan adanya aplikasi ini dapat mempermudah pegawai dalam mendata hotel yang ada di Banjarmasin dan mempercepat pegawai dalam pembuatan laporan untuk kepala dinas sehingga mempermudah kinerja pegawai bidang pariwisata. Kata Kunci: Aplikasi Hotel, Website, Waterfall, DISBUDPORAPAR.
The effect of manganese and carbon on the mechanical properties of the welded layer of the bucket teeth of the Hadfield steel excavator
Authors: Posonskyi S.F. 
Published: September 2024

The paper investigates the effect of the surfacing composition’s chemical structure (the manganese and carbon concentrations’ ratio) on the mechanical properties of the surfacing layer on Hadfield steel for increasing the durability of the products made from it, namely the excavator bucket’s teeth. Two criteria, namely the impact toughness and wear resistance of the coating, were chosen as optimization parameters. The assessment of the impact strength of the deposited coating was carried out on the Sharpie samples on the pendulum copra, and the wear test was carried out according to the Brinly-Haworth scheme in the conditions of samples’ abrasion with quartz sand. Wear resistance of Hadfield steel, containing 1.1% C and 13% Mn, was taken as a unit of wear resistance in these experiments. To determine the optimal coating modes, the active experiment with the application of mathematical planning methods was conducted. The obtained response surfaces and graphs of equal output lines make it possible to establish the level of studied factors’ influence on the optimization parameter. In order to analyze the influence of given factors on the optimization criteria, scatter plots with histograms were constructed, which make it possible to determine the rational values ​​of the selected optimization criteria graphically - impact toughness and wear resistance of the coating