bluuebunny/crossref_metadata_2025_split huggingface dataset:
Versatile and Efficient Protein Association Through Chemically Modified Sphingomyelin Nanosystems (SNs) for Enhanced Delivery
Authors: Abal‐Sanisidro Marcelina , Nieto‐García Olaia , Cotelo‐Costoya Cristina , de la Fuente María 
Published: September 2024

AbstractProteins are biological macromolecules well known to regulate many cellular signaling mechanisms. For instance, they are very appealing for their application as therapeutic agents, presenting high specificity and activity. Nonetheless, they suffer from unfolding, instability and low bioavailability making their administration through systemic and other routes very tough. To overcome these drawbacks, drug delivery systems and nanotechnology have arisen to deliver biomolecules in a sustained manner while, at the same time, increasing dose availability, protecting the cargo without compromising proteins’ bioactivity, and enhancing intracellular delivery. In this work, we proposed the optimization of sphingomyelin nanosystems (SNs) for the delivery of a wide collection of proteins (ranging from 10–500 kDa and pI) using diverse chemical association strategies. We have further characterized SNs by varied analytical methodologies. We have also carried out in vitro experiments to validate the potential of the developed formulations. As the final goal, we aim to obtain evidence of the potential use of SNs for the development of protein therapeutics.
Synthesis of Substituted Acyclic and Cyclic N‐Alkylhydrazines by Enzymatic Reductive Hydrazinations
Authors: Borlinghaus Niels , Calabrese Donato , Lauterbach Lars , Nestl Bettina M. 
Published: September 2024

AbstractImine reductases (IREDs) provide promising opportunities for the synthesis of various chiral amines. Initially, asymmetric imine reduction was reported, followed by reductive aminations of aldehydes and ketones via imines. Herein we present the reductive amination of structurally diverse carbonyls and dicarbonyls with hydrazines (reductive hydrazination), catalyzed by the IRED from Myxococcus stipitatus. In analogy to IRED‐catalyzed reductive aminations, various carbonyls and dicarbonyls could react with simple hydrazines to produce substituted acyclic and cyclic N‐alkylhydrazines. By incorporating and scaling up a hydrogenase cofactor regeneration system, we demonstrated the scalability and atom‐efficiency of an H2‐driven double reductive hydrazination, highlightling the potential of IREDs in biocatalysis.
Gliosarcoma associated with bilateral hippocampal sclerosis in a cat presenting complex partial seizures with orofacial involvement: A case report
Authors: Martinez Ana , Binks Sophie , Pumarola Martí , Hardas Alexandros , Easton Alistair , Campo Leticia , Browne Molly , Martins Susana , Garosi Laurent S. , Di Dona Francesco , Tauro Anna 
Published: September 2024

Key Clinical MessageGliosarcoma, a rare cerebral neoplasm, has not been linked to hippocampal changes in cats. We report a case of complex partial seizures with orofacial involvement, revealing gliosarcoma concurrent with bilateral hippocampal sclerosis.AbstractA 16‐year‐old neutered female domestic shorthair cat presented with acute inappetence, ataxia, disorientation, and vacant staring. Brain MRI revealed an ill‐defined, round, intra‐axial mass in the right piriform lobe, showing hyperintensity on T2W, T2‐FLAIR, and T2*W, and hypointensity on T1W images. The lesion exhibited mass effect and contrast enhancement in its center. Bilateral hyperintensity on T2‐FLAIR images and contrast enhancement were observed in the hippocampus. Brain histologic and immunohistochemical analysis revealed cerebral gliosarcoma with concurrent hippocampal sclerosis. Feline LGI1‐antibody testing on the serum and/or CSF was not performed due to insufficient biomaterial. Although retrospective testing on brain tissue was considered, it ultimately proved unfeasible, preventing us from ruling out antibody‐associated limbic encephalitis. In conclusion, cerebral gliosarcoma should be included in feline intracranial tumor differentials, warranting brain MRI and feline LGI1‐antibody testing in cats showing complex partial seizures with orofacial involvement. In our case, the prognosis remained poor due to the presence of a high‐grade glioma.
Epoxidation at Isolated Titanium Site Modeled by Ti‐Siloxy‐Polyoxometalates Built on [α–A–XW9O34]n− and [α–B–YW9O33]9−: Comparative Study of Their Hydrolytic Stability
Authors: K/Bidi Ludivine , Solé‐Daura Albert , Zhang Teng , Desjonquères Alix , Poblet Josep M. , Proust Anna , Carbó Jorge J. , Guillemot Geoffroy 
Published: September 2024

AbstractThis report investigates the structural differences in a series of titanium complexes constructed from silanol functionalized polyoxometalate (SiloxPOMs) derivatives, designed to create a constrained coordination site for titanium (IV) cations, namely (THA)3[PW9O34(tBuSiO)3Ti(OiPr)] and (THA)3[SbW9O33(tBuSiO)3Ti(OiPr)]. The complexes serve as structural and functional models for titanium silicates, facilitating the epoxidation of allylic alcohols and alkenes by aqueous hydrogen peroxide solutions. The different activity and selectivity observed between the two derivatives are attributed to variations in the polyoxotungstic platform used, A‐type–[XW9O34]n− versus B‐type –[YW9O33]3−. A combined experimental and theoretical investigation highlights the influence of these structural differences on water interaction and hydrolytic stability, with A‐type structures proving more susceptible to hydrolysis. In addition, the study also delves into the nuclearity of the active sites, a monomeric titanium (IV)‐hydroperoxide [Ti]–(OOH) active species evidenced by diffusion NMR spectroscopy, and the influence of the presence of water on catalytic performance in epoxidation reaction, thus shedding light on the relationship between catalyst stability, intermediates formed and reaction pathway. The study finally demonstrates the suitability of B‐type SiloxPOM derivatives as models for titanium silicates, offering insights into their stability and catalytic activity for epoxidation reactions.
Ionomeric Binders for High Temperature Proton Exchange Membrane Fuel Cells
Authors: Xing Ruiyang , Yu Yaqin , Li Nanwen , Geng Kang , Tang Hongying 
Published: September 2024

AbstractHigh‐temperature proton exchange membrane fuel cell (HT‐PEMFC) based on phosphoric acid doped polybenzimidazole membrane (PBI/PA) operating at 120–200 °C can provide insensitivity to carbon monoxide (CO) and simplified managements of water and heat and thus attract significant global attention. However, one significant drawback is its low utilization of precious metal catalysts resulted from the PA poisoning and inefficient three‐phase boundary. Studies of binder materials in catalyst layers for HT‐PEMFC are gradually emerging and there are few literature reviews on this important topic. The purpose of this review is to describe the various types of binders based on their molecular structure and electrochemical properties, with particular emphasis on catalyst layer for fuel cells. Importantly, this review provides a better understanding of relationship between fuel cell performance and the gas permeability and conductivity of different binders. Then, future directions of research and development in binder materials of HT‐PEMFC are pointed out.
Green‐Light Hydrosilylation Photocatalysis with Platinum(II)Metalla‐N‐Heterocyclic Carbene Complexes
Authors: Kashina Maria V. , Luzyanin Konstantin V. , Katlenok Eugene A. , Kinzhalov Mikhail A. 
Published: September 2024

AbstractPlatinum(II) metalla‐N‐heterocyclic carbene complexes featuring pyridyl heterocyclic moiety demonstrate remarkable catalytic efficiency in alkyne hydrosilylation under green light irradiation. The photocatalytic properties of complexes are rationalised by the photo‐induced charge transfer occurring in extended condensed system identified with the help of various experimental (UV/vis and emission spectroscopy, cyclic voltammetry) and theoretical methods (DFT/TD‐DFT, IFCT analysis).
Skeleton Rearranged and Oxygenated ent‐Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii
Authors: Song Qin‐Qin , Guo Yue , Sun Peng , Fan Yao‐Yue , Ji Kai‐Long 
Published: September 2024

Comprehensive SummaryFive unreported and oxygenated ent‐rosane diterpenoids (ent‐RDs), Euphomillanols A—E (1—5), were isolated from Euphorbia milii. Among them, compounds 1 and 2 are unprecedented 7/7/6‐fused tricyclic 5,10‐seco‐ent‐RDs and possess a unique 11‐oxabicyclo[4.4.1]undeca‐1(10),5‐diene moiety, while 3 is characterized by a 1‐methyl‐6‐oxabicyclo[3.2.1]oct‐2‐ene motif of ring A. Their structures with absolute configurations were unambiguously determined by the extensive spectroscopic methods, X‐ray crystallography, and ECD calculation. Putative biosynthetic pathways for compounds 1—3 are proposed. All compounds exhibited antiadipogenic effects in 3T3‐L1 adipocytes, and the most potent compound 4 showed an EC50 value of 3.92 μmol/L with low cytotoxicity (IC50 > 89.54 μmol/L).
Searching for studies: A guide to information retrieval for Campbell systematic reviews
Authors: MacDonald Heather , Comer Cozette , Foster Margaret , Labelle Patrick R. , Marsalis Scott , Nyhan Kate , Premji Zahra , Rogers Morwenna , Splenda Ryan , Stansfield Claire , Young Sarah 
Published: September 2024

AbstractThis guide outlines general issues in searching for studies; describes the main sources of potential studies; and discusses how to plan the search process, design, and carry out search strategies, manage references found during the search process and document and report the search process.
Rice Straw Biochar as an Effective Support for Pd Nanoparticles for Ethanol Electro‐Oxidation Reaction in Alkaline Condition
Authors: Villanueva Matthew L. , Laxamana Justienne Rei P. , Necesito Hannah Grace G. , Garcia Jonyl L. , Tongol Bernard John V. 
Published: September 2024

AbstractHerein, we report the utilization of biochar derived from rice straw (RSB) as an effective support matrix for Pd nanoparticles and its application as an electrocatalyst for ethanol electro‐oxidation (EEO) in an alkaline medium. Rice straw, a common agricultural byproduct, was pyrolyzed at 600 °C, 700 °C, and 800 °C under N2 atmosphere. Pd was loaded onto the RSB via borohydride reduction of Pd2+, with a nominal loading of 20 % Pd. Spectroscopic and morphological characterization revealed the formation of dispersed Pd nanoparticles on the RSB surface. Pyrolysis temperature was observed to influence both the porosity of the resulting RSB and the dispersion and degree of exposure of Pd nanoparticles deposited on the surface. Electrochemical characterization revealed that Pd/RSB could be a potential EEO electrocatalyst for direct ethanol fuel cell applications. Pd/RSB‐700 exhibited better performance in terms of EEO forward mass activity (jf) and forward and backward mass activity (jf/jb) ratio relative to Pd/RSB‐600 and Pd/RSB‐800. Moreover, Pd/RSB was shown to be superior to commercial Pd on carbon black in terms of electrochemical stability. This study opens the potential of rice straw biochar as a sustainable and environmentally friendly carbon‐based support matrix for Pd‐based EEO electrocatalysts.
Propagation Characteristics of Electrostatic Surface Plasma Waves at the Spin‐Polarized Quantum Plasma–Vacuum Interface
Authors: Adnan Muhammad , Nazir Muhammad , Ikramullah  , Khattak Fida Younus 
Published: September 2024

ABSTRACTThis investigation explores the characteristics of electrostatic surface plasma waves within the framework of a spin‐polarized quantum plasma. Utilizing the spin‐polarized quantum hydrodynamic model and incorporating essential elements like Fermi pressure and Bohm potential, we derive the dispersion relation governing surface plasma waves at a plasma–vacuum interface. Through Fourier decomposition of the hydrodynamic model, we establish the dispersion relation that outlines the behavior of surface plasmons under conditions of small amplitude. Quantum effects, encompassing degenerate pressure, and Bohm potential are considered with specific attention given to the spin polarization effect, treating spin up, and spin down electrons as distinct species. The resulting dispersion relation demonstrates that, regardless of the degree of spin matching, Bohm potential significantly alters the phase speed in the limit of a large wave vector. Increasing spin mismatch in the quantum plasma leads to a decrease in the phase speed of the surface mode for a fixed value of the plasmonic coupling parameter . Our findings bear relevance to graphene‐based plasmonic systems, aligning with some of the observations reported in Gao et al. (2013) and Guo et al. (2019).
Energy‐efficient optimal sink placement using extended pelican optimization‐based clustering with Voronoi‐based node deployment
Authors: Abdur Rahman Narayanasami , Shankarlal Balraj , Sivarajan Sankarapandian , Sharmila Pandian 
Published: September 2024

SummaryA wireless sensor network (WSN) is a network of spatially distributed autonomous sensor nodes that collaborate to monitor physical or environmental conditions, collect data, and transmit it to a sink node. WSNs have a wide range of applications across various domains due to their ability to provide real‐time data collection, remote monitoring, and data analysis. Still, in a WSN with a fixed sink, sensor nodes closer to the sink tend to have higher traffic loads because they forward data to nodes further away. This can lead to hotspots and uneven energy consumption. Introducing a mobile sink can distribute the traffic more evenly across the network, reducing congestion and balancing the energy consumption among nodes. Hence, this research proposes a novel WSN environment with a focus on energy‐efficient routing. The network is deployed using Voronoi‐based criteria to address network coverage issues. The clustering of nodes is employed using the proposed extended pelican optimization (ExPo) algorithm to improve network lifetime and energy efficiency, critical concerns in WSNs due to limited sensor node battery capacity. Cluster heads (CHs) aggregate and process data locally, reducing the energy needed for long‐range communication. Then, an energy‐efficient optimal sink placement (EEOSP) approach is used to optimize the placement of the mobile sink. The proposed system model is evaluated based on various metrics, including average residual energy, delay, network lifetime, packet delivery ratio, and throughput and acquired the values of 0.99 J, 3.68 ms, 99.55%, 99.55%, and 81 Mbps, respectively.
Mesopredators have differing influences on prey habitat use and diel activity in a multipredator landscape
Authors: Palomo‐Munoz Gabriela , Fidino Mason , Werdel Ty J. , Piper Colleen W. , Gallo Travis , Peek Matthew S. , Ricketts Andrew M. , Ahlers Adam A. 
Published: September 2024

AbstractResource distribution, habitat structure, and predators greatly influence spatial and temporal landscape use by prey species. The “risky places” hypothesis establishes prey will proactively respond to predators' presence based on habitat cues, whereas the “risky times” hypothesis predicts prey will reactively respond by increasing vigilance in the presence of predators regardless of habitat cues. We fit a multiscale, Bayesian species interaction occupancy model with detection/non‐detection data to evaluate black‐tailed jackrabbit (Lepus californicus) and eastern cottontail rabbit (Sylvilagus floridanus) habitat use in the presence and absence of coyotes (Canis latrans), American badgers (Taxidea taxus), and swift foxes (Vulpes velox). We also evaluated how species‐specific predator presence modified temporal activity patterns of prey. Jackrabbits decreased habitat use in areas with greater forage and opted to use areas with greater visibility when coyotes or swift foxes were present. However, cottontails used habitat in open areas with greater visibility when American badgers were present and all other predators absent, suggesting dissimilar habitat‐use patterns dictated by predator‐specific risks. Both lagomorph species are nocturnal with segregated peaks of activity compared with predators, suggesting fine‐scale temporal use partitioning. Our results provide insights into predator–prey dynamics across heterogenous landscapes in a multi‐predator system.
Parasitic plants regulate C and N distribution among common mycorrhizal networks linking host and neighboring plants
Authors: Yuan Yongge , Han Cheng , Wang Jiani , Li Junmin 
Published: September 2024

AbstractCommon mycorrhizal networks (CMNs) can link multiple plants and distribute nutrients among them. However, how parasitic plants regulate the carbon and nutrient exchange between CMNs and the linked plants is unknown. Thus, we conducted a container experiment with two Trifolium pratense grown in two plastic cores and connected only by CMNs using a 25‐μm nylon fabric in each container. Host T. pratense was parasitized or not parasitized by Cuscuta gronovii. CMNs were left intact or broken by rotating the cores with the host or neighboring T. pratense. The dual 15N and 13C labeling method was used to evaluate the N distributed by CMNs to the host and neighboring T. pratense and the recently fixed C from the host and neighboring T. pratense to CMNs. The results showed that CMNs distributed more 15N to unparasitized neighboring T. pratense than the parasitized host T. pratense. Moreover, the unparasitized neighboring T. pratense provides more recently fixed C to CMNs than the parasitized host T. pratense. These results revealed that the parasite regulated C and nutrient exchange between CMNs and the linked plants following the reciprocal rewards rule. Moreover, this study highlights the importance of parasitic plants in the regulation of mutualistic interactions in ecological webs.
Intravenous lacosamide for acute repetitive seizures and convulsive status epilepticus in critically ill children
Authors: Hsiao Man‐Ru , Tsai Tzu‐Cheng , Hsia Shao‐Hsuan , Chan Oi‐Wa , Lee En‐Pei , Lin Jainn‐Jim , Lin Kuang‐Lin 
Published: September 2024

AbstractObjectiveAcute repetitive seizures and convulsive status epilepticus are common neurological emergencies in critically ill children. The aim of the study was to evaluate the effectiveness and safety of intravenous lacosamide in critically ill children with acute repetitive seizures and convulsive status epilepticus.MethodsThis retrospective study included children who received intravenous lacosamide for acute repetitive seizures or convulsive status epilepticus from October 2017 to September 2022 and were admitted to the pediatric intensive care unit at a tertiary medical center. Children who were newly started on intravenous lacosamide were included and divided into two groups: (a) previously healthy, and (b) history of epilepsy and receiving antiseizure medications. Efficacy was defined as the cessation of seizures within 72 h of administering lacosamide. Adverse effects were defined using predefined criteria, and most were evaluated during the first 7 days.ResultsSixty‐seven children were enrolled, including 25 (37.3%) girls and 42 (62.7%) boys with a mean age of 7.20 ± 5.66 years. Among them, 30 (44.8%) had acute repetitive seizures, and 37 (55.2%) had convulsive status epilepticus. The seizure types were focal onset (n = 34, 50.7%), generalized onset (n = 27, 40.3%), and mixed type (n = 6, 9.0%). In the previously healthy group, 9 patients had acute repetitive seizures and 23 had convulsive status epilepticus, and the rates of seizure cessation when lacosamide was used as the first to fourth choice of antiseizure medication were 100.0%, 85.7%, 40.0%, and 50.0%, respectively, compared to 73.7%, 54.5%, 100.0%, and 0.0% in the patients with epilepsy (21 had acute repetitive seizures and 14 had convulsive status epilepticus). Sixteen (23.9%) patients developed bradycardia and 1 (1.5%) patient developed a rash.SignificanceThe early use of intravenous lacosamide was effective with acceptable side effects in treating acute repetitive seizures and convulsive status epilepticus in critically ill children, including young infants and children less than 4 years old and those with different etiologies.Plain Language SummaryAcute repetitive seizures and convulsive status epilepticus are common neurological emergencies in pediatric intensive care units (PICUs), traditional intravenous antiseizure medications (ASMs) include phenytoin, valproic acid, levetiracetam, and phenobarbital. In this study, we categorized patients based on their epilepsy history and different etiologies. We observed that early use of lacosamide, even in young infants, demonstrated good efficacy and safety.
Optimal Scheduling of Renewable Sources Based Micro Grid With PV and Battery Storage Using Crayfish Optimization Algorithm
Authors: Bhol Subrat , Sahu Nakul Charan 
Published: September 2024

ABSTRACTEnvironmental concerns and energy security are pressing issues of the 21st century, with a heavy reliance on fossil fuels causing significant environmental pollution and resource depletion. To mitigate these problems, it is crucial to explore and implement alternative clean energy sources. This manuscript proposes a novel crayfish optimization algorithm (COA) for optimal scheduling in a hybrid power system that incorporates various renewable energy sources, like battery energy storage systems (BESS), fuel cells (FC), wind turbines (WT), micro turbines (MT) and photovoltaic (PV) panels. The importance of the work lies in its ability to optimize the entire operating costs of a grid‐connected microgrid while improving the accuracy and efficiency of energy management. The COA method addresses economic dispatch problems and manages energy within the grid‐connected microgrid, accounting for high levels of uncertainty. The proposed approach, tested using MATLAB Simulink, achieved a cost value of 252, outperforming existing methods such as GTO, PSO, SSA, and ALO. This illustrates the potential of the proposed technique to provide more cost‐effective and efficient energy management solutions in hybrid power systems.
Extended postpartum intimate partner violence and its associated factors among Iranian women: Community‐based cross‐sectional study design
Authors: Ghelichkhani Fatemeh , Behboodi Moghadam Zahra , Zareiyan Armin , Namazi Masoumeh 
Published: September 2024

AbstractObjectiveThe purpose of this study was to determine the prevalence of different types of intimate partner violence (IPV) and factors associated with it during the postpartum period.MethodsIn this cross‐sectional study, 428 women were enrolled from 10 health centers in the south of Tehran, Iran, between April 2023 and October 2023. We used a sociodemographic questionnaire, Conflict Tactics Scale (CTS2), the short form of the Connor‐Davidson Resilience Scale (CD‐RISC), and the Depression, Anxiety and Stress Scale (DASS‐21) for data collection. Multivariate binary logistic regression was used to determine demographic and psychological predictors of IPV after childbirth.ResultsApproximately two‐thirds of women (n=285, 66.6%) experienced IPV within 1 year of childbirth. Psychological aggression (n= 276, 64.5%) was the most common type of IPV, whereas injury (n=96, 22.4%) was the least common. Additionally, one in three women experienced physical assault (n= 134, 31.3%), and over one‐third experienced sexual coercion (n= 152, 35.5%). Predictor factors of IPV during the postpartum period were: insufficient family income (adjusted odds ratio [aOR] 4.52, 95% confidence interval [CI] 1.24–15.28), husband's smoking (aOR 3.17, 95% CI 1.70–5.92), history of IPV in pregnancy (aOR 2.44, 95% CI 1.33–4.50), number of children (aOR 3.02, 95% CI 1.79–5.10), and depression (aOR 1.2, 95% CI 1.08–1.14). On the other hand, protective factors of IPV during the postpartum period were: longer marriage duration (aOR 0.85, 95% CI 0.77–0.93) and greater resilience (aOR 0.95, 95% CI 0.90–0.99).ConclusionIPV is prevalent 1 year after childbirth. Healthcare providers should implement a thorough screening program to identify risk and protective factors related to postpartum IPV.