bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posttraumatic Stress and Burnout Symptoms in Forensic Doctors and Staff in a Mortuary
Authors: Kömür İlhami , Ozdemirel Rifat O. , Ozver İsmail , Başpinar Bünyamin , Demir Muhammet , Gönen Fatih , Kandemir Eyüp , Emul Murat 
Published: July 2017

AbstractWe aimed to investigate burnout and posttraumatic stress symptoms in mortuary staff members who work for the Council of Forensic Medicine where more than 4500 autopsies are annually performed.The data were collected from 142 mortuary staff members from the Council of Forensic Medicine, Turkey. The participants were divided into the following 4 groups: forensic medicine specialists (n = 40, 28.2%), forensic medicine residents (n = 54, 38.0%), autopsy technicians (n = 24, 16.9%), and other staff members (n = 24, 16.9%). All of the participants completed a brief sociodemographic form and standardized questionnaires to assess health symptoms, such as the Maslach Burnout Inventory and Posttraumatic Symptom Screening Scale.Forensic medicine staff members are at risk for developing psychological health symptoms, such as burnout or posttraumatic stress, due to work-related stressors. We observed that autopsy technicians seemed to have more emotional exhaustion and posttraumatic stress disorder symptoms, whereas resident doctors had a lower sense of personal accomplishment.
A SWIFT Method for Handing Off Obstetrical Patients on the Labor Floor
Authors: Sheen Jean-Ju , Reimers Laura , Govindappagari Shravya , Ngai Ivan M. , Garretto Diana , Donepudi Roopali , Tropper Pamela , Goffman Dena , Dayal Ashlesha K. , Bernstein Peter S. 
Published: July 2017

Objective
The aim of this study was to improve patient handoffs on the labor floor.

Methods
A prospective cohort study of obstetrics residents at Montefiore Medical Center was performed between 2012 and 2014. Labor-floor handoffs were recorded before and after didactic sessions as well as after installation of whiteboards formatted with the mnemonic SWIFT (Subject, Why?, Issues, Fetus, Tasks). Handoff transcripts were evaluated by obstetricians blinded to timing and speaker identity. An intraclass correlation coefficient accounted for evaluator differences. Data analysis was by ordinal logistic regression, the generalized estimating equations method (correlated data), and Bonferroni adjustment (multiple comparisons).

Results
Forty-five handoffs were evaluated (15 each predidactics, postdidactics, and postwhiteboard revision). Higher completeness scores over time were noted for admission reason, labor concerns, and task list (not statistically significant). Comprehensive score increases prelecture to postwhiteboard were seen in handoff clarity (2.81 versus 2.91) and overall quality (2.77 versus 2.81) (not statistically significant). A subanalysis of four residents who gave multiple handoffs over different periods revealed few significant changes over time. Greater interevaluator consistency was noted with more objective elements.

Conclusions
The mnemonic SWIFT, with formalized curricula for obstetrical resident training focusing on new learners and increased faculty involvement and reinforcement, may result in improvement of handoffs on the labor floor.
Retransplantation in Late Hepatic Artery Thrombosis: Graft Access and Transplant Outcome
Authors: Buchholz Bettina M. , Khan Shakeeb , David Miruna D. , Gunson Bridget K. , Isaac John R. , Roberts Keith J. , Muiesan Paolo , Mirza Darius F. , Tripathi Dhiraj , Perera M. Thamara P.R. 
Published: July 2017

Background
Definitive treatment for late hepatic artery thrombosis (L-HAT) is retransplantation (re-LT); however, the L-HAT–associated disease burden is poorly represented in allocation models.

Methods
Graft access and transplant outcome of the re-LT experience between 2005 and 2016 was reviewed with specific focus on the L-HAT cohort in this single-center retrospective study.

Results
Ninety-nine (5.7%) of 1725 liver transplantations were re-LT with HAT as the main indication (n = 43; 43%) distributed into early (n = 25) and late (n = 18) episodes. Model for end-stage liver disease as well as United Kingdom model for end-stage liver disease did not accurately reflect high disease burden of graft failure associated infections such as hepatic abscesses and biliary sepsis in L-HAT. Hence, re-LT candidates with L-HAT received low prioritization and waited longest until the allocation of an acceptable graft (median, 103 days; interquartile range, 28-291 days), allowing for progression of biliary sepsis. Balance of risk score and 3-month mortality score prognosticated good transplant outcome in L-HAT but, contrary to the prediction, the factual 1-year patient survival after re-LT was significantly inferior in L-HAT compared to early HAT, early non-HAT and late non-HAT (65% vs 82%, 92% and 95%) which was mainly caused by sepsis and multiorgan failure driving 3-month mortality (28% vs 11%, 16% and 0%). Access to a second graft after a median waitlist time of 6 weeks achieved the best short- and long-term outcome in re-LT for L-HAT (3-month mortality, 13%; 1-year survival, 77%).

Conclusions
Inequity in graft access and peritransplant sepsis are fundamental obstacles for successful re-LT in L-HAT. Offering a graft for those in need at the best window of opportunity could facilitate earlier engrafting with improved outcomes.
Structure and Function of the Human Insula
Authors: Uddin Lucina Q. , Nomi Jason S. , Hébert-Seropian Benjamin , Ghaziri Jimmy , Boucher Olivier 
Published: July 2017

Summary:
The insular cortex, or “Island of Reil,” is hidden deep within the lateral sulcus of the brain. Subdivisions within the insula have been identified on the basis of cytoarchitectonics, sulcal landmarks, and connectivity. Depending on the parcellation technique used, the insula can be divided into anywhere between 2 and 13 distinct subdivisions. The insula subserves a wide variety of functions in humans ranging from sensory and affective processing to high-level cognition. Here, we provide a concise summary of known structural and functional features of the human insular cortex with a focus on lesion case studies and recent neuroimaging evidence for considerable functional heterogeneity of this brain region.
Misleading EEG Lateralization Associated With Midline Shift
Authors: Ghearing Gena R. , Abramovici Sergiu , Popescu Alexandra , Baldwin Maria E. 
Published: July 2017

Summary:
Midline discharges, lateralized periodic discharges, and seizures have been described with ipsilateral lesions that result in midline shift (MLS). Periodic discharges and seizures arising contralateral to a known lesion have not previously been described as a sign of MLS. We present four patients with focal brain lesions, resulting in MLS and epileptiform discharges arising from the contralateral hemisphere. Patient 1 underwent a right anterior temporal lobectomy. On postoperative day 2, computed tomography demonstrated a right to left MLS of 12 mm, and EEG was remarkable for left temporal nonconvulsive status epilepticus. Patient 2 experienced a subarachnoid hemorrhage, which was more prominent on the left. Computed tomography after craniotomy demonstrated left to right MLS of 6 mm, and EEG was remarkable for right lateralized periodic discharges. Patient 3 had a right subdural hematoma and underwent craniotomy for evacuation. On postoperative day 3, computed tomography demonstrated a right MLS of 7 mm, and EEG was remarkable for left temporal nonconvulsive status epilepticus. Patient 4 had traumatic brain hemorrhages with maximal left frontotemporal involvement. Six days after the trauma, computed tomography was significant for left to right MLS of 9 mm, and EEG showed right lateralized periodic discharges. Epileptiform discharges and seizures occurring contralateral to a known lesion may be an indicator of MLS.
Mapping-based all-RNA-information sequencing analysis (ARIseq) pipeline simultaneously revealed taxonomic composition, gene expression, and their correlation in an acidic stream ecosystem
Authors: Tsuboi Arisa , Itoga Misao , Hongoh Yuichi , Moriya Shigeharu 
Published: July 2017

AbstractWe developed a new pipeline for simultaneous analyses of both rRNA profile as a taxonomic marker and mRNA profile as a functional marker, to understand microbial ecosystems in natural environments. Our pipeline, named All-RNA-Information sequencing (ARIseq), comprises a high-throughput sequencing of reverse transcribed total RNA and several widely used computational tools, and generates quantitatively reliable information on both community structures and gene expression patterns, which were verified by quantitative PCR analyses in this study. Particularly, correlation network analysis in the pipeline can reveal microbial taxa and expressed genes that share patterns of dynamics among different time and/or geographical points. The pipeline is primarily mapping-based, using a public database for small subunit rRNA genes and obtained contigs as the reference database for protein-coding genes. We applied this pipeline to biofilm samples, as examples, collected from an acidic spring water stream in the Chyatsubomi-goke Park in Gunma prefecture, Japan. Our analyses revealed the predominance of iron and sulfur-oxidizing bacteria andPinnulariadiatoms, and also indicated that the distributions of the iron-sulfur-oxidizing bacterial consortium and thePinnulariadiatoms largely overlapped but showed distinct patterns. In addition, our analyses showed that the iron-oxidizing bacterial genusAcidithiobacillusand co-occurringAcidiphiliumshared similar distribution pattern whereas another iron-oxidizing genusLeptospirillumexhibited a distinct pattern. Our pipeline enables researchers to more easily capture the outline of microbial ecosystems based on the taxonomic composition, protein-coding gene expression, and their correlations.
Quantifying 35 transcripts in a single tube: Model-based calibration of the GeXP RT-PCR assay
Authors: Marquardt Pauline , Werthmann Britta , Rätzel Viktoria , Haas Markus , Marwan Wolfgang 
Published: July 2017

AbstractQuantitative analysis of differential gene expression is of central importance in molecular life sciences. The Gene eXpression Profiling technology (GeXP) relies on multiplex RT-PCR and subsequent capillary electrophoretic separation of the amplification products and allows to quantify the transcripts of up to approximately 35 genes with a single reaction and one dye. Here, we provide a kinetic model of primer binding and PCR product formation as the rational basis for taking and evaluating calibration curves. With the help of a purposeful designed data processing workflow supported by easy-to-use Perl scripts for calibration, data evaluation, and quality control, the calibration procedure and the model predictions were confirmed and the robustness and linearity of transcript quantification demonstrated for differentiatingPhysarum polycephalumplasmodial cells. We conclude that GeXP analysis is a robust, sensitive, and useful method when the transcripts of tens to few hundred genes are to be precisely quantified in a high number of samples.
Privacy-preserving generative deep neural networks support clinical data sharing
Authors: Beaulieu-Jones Brett K. , Wu Zhiwei Steven , Williams Chris , Lee Ran , Bhavnani Sanjeev P. , Byrd James Brian , Greene Casey S. 
Published: July 2017

AbstractBackgroundData sharing accelerates scientific progress but sharing individual level data while preserving patient privacy presents a barrier.Methods and ResultsUsing pairs of deep neural networks, we generated simulated, synthetic “participants” that closely resemble participants of the SPRINT trial. We showed that such paired networks can be trained with differential privacy, a formal privacy framework that limits the likelihood that queries of the synthetic participants’ data could identify a real a participant in the trial. Machine-learning predictors built on the synthetic population generalize to the original dataset. This finding suggests that the synthetic data can be shared with others, enabling them to perform hypothesis-generating analyses as though they had the original trial data.ConclusionsDeep neural networks that generate synthetic participants facilitate secondary analyses and reproducible investigation of clinical datasets by enhancing data sharing while preserving participant privacy.
TheDrosophiladystonia gene homologNeurocalcinfacilitates sleep by inhibiting a movement-promoting neural network
Authors: Chen Ko-Fan , Lamaze Angélique , Krätschmer Patrick , Jepson James E.C. 
Published: July 2017

AbstractPrimary dystonia is a hyperkinetic movement disorder linked to altered dopaminergic signaling and synaptic plasticity in regions of the brain involved in motor control. Mutations inHPCA, encoding the neuronal calcium sensor Hippocalcin, are associated with primary dystonia, suggesting a function for Hippocalcin in regulating the initiation and/or maintenance of activity. However, such a role for Hippocalcin or Hippocalcin homologs has yet to be demonstrated in vivo. Here we investigate the cellular and organismal functions of theDrosophilaHippocalcin homolog Neurocalcin (NCA), and define a role for NCA in promoting sleep by suppressing nighttime hyperactivity. We show that NCA acts in a common pathway with the D1-type Dop1R1 dopamine receptor and facilitates sleep by inhibiting neurotransmitter release from a multi-component activity-promoting circuit. Our results suggest conserved roles for Hippocalcin homologs in modulating motor control through dopaminergic pathways, suppressing aberrant movements in humans and inappropriate nighttime locomotion inDrosophila.
Business model innovation, strategic information and the role of analyst firms
Authors: Parnell Brett David , Stott Ryan , Stone Merlin , Aravopoulou Eleni , Timms Lucy 
Published: July 2017

Purpose
The purpose of this paper is to explore the role of analysts in providing information to support business model innovation.

Design/methodology/approach
This paper is based on initial research by two of the co-authors on business models (Stott et al., 2016), to which is added the experience of members of the team in working in strategic analyst firms or in working closely with clients of business analyst firms and further secondary data.

Findings
The findings of this paper show that analysts could do more to help their clients capture the opportunities and meet the threats of business model innovation, but this may require business leaders and analyst firms to think differently about their mutual relationship, particularly the briefs that clients provide analysts and how analysts aggregate information to provide a clearer picture of business model choices and their likely consequences.

Research limitations/implications
This paper needs confirmation of views by primary empirical research.

Practical implications
This study identifies the need for firms to brief their analysts to provide much enhanced information concerning business model opportunities and threats, and for teachers and researchers in marketing to become more closely acquainted with the business model literature and analyst reports and processes.

Social implications
As the idea of business model change becomes a more acceptable part of the strategic armoury of firms, the understanding of the information requirements to support such change to become more widely understood, and business model change to be consequently more common can be expected. This paper contributes to the understanding of the information requirements involved in such changes.

Originality/value
This study highlights the gap in the discussion of information provision to business leaders concerning business model innovation requirements and threats.
A typology for management innovations
Authors: Gebauer Heiko , Haldimann Mirella , Jennings Saul Caroline 
Published: July 2017

PurposeThe purpose of this paper is to develop a typology of management innovations.Design/methodology/approachThe authors apply a multiple-case (embedded) design, with each organization representing a case, which entails a few embedded units of analysis. Case studies are about the base-of-the-pyramid (BoP) initiatives, during which all organizations are interested in management innovations which support them in coming up with and implementing between two and four new management practices.FindingsThe findings suggest four types of management innovations: efficiency-driven, externally recommended, problem-oriented, and opportunity-oriented management innovation.Research limitations/implicationsThis paper explores and analyses management innovations, rather than testing them. As with most qualitative research, the transferability of the findings is limited.Practical implicationsManagers should vigorously pursue management innovations, not only in BoP markets, but also in all markets. Practitioners must, however, ensure that they are not fully absorbed by a single type of management innovation, and recognize the importance of pursing multiple ones.Social implicationsFor academics, the authors revitalize the concept of engaged scholarship.Originality/valueSurprisingly, previous research looks either into generic or specific management innovations. The typology is original, since the typology offers a more fine-grained view on management innovations.
Managing the fuzzy front-end in multicultural teams
Authors: Neukam Marion Nathalie 
Published: July 2017

PurposeThe purpose of this paper is to identify coordination mechanisms for multicultural teams at the fuzzy front-end (FFE) of discontinuous product innovations to maintain their creative potential by limiting the negative effects of cultural differences of individual nations.Design/methodology/approachBased on a case study, the international teamwork at the FFE was analyzed at Bürkert, a German medium-sized firm active in the industrial sector.FindingsIn correlation with the academic literature, the findings suggest that a strong organizational culture oriented toward innovation delivers a common framework for the FFE. Additionally, the case company succeeded in limiting the negative effects of individual nations’ cultures through common professional cultures.Research limitations/implicationsData were collected from a single case study what limits its generalizability. Moreover, national culture was considered to be overlapping with political boundaries without taking regional differences into account. Future research should focus to overcome these limitations so as to better capture international challenges at this fuzzy phase of the innovation process.Practical implicationsCompanies should focus on their corporate culture and use the concept of professional cultures to facilitate not only the international collaboration, but also the communication on a national level between the functional departments at the FFE.Originality/valueThe paper contributes to a better understanding of the FFE in a multicultural innovation team to sustain its innovative potential over time. It proposes a first parsimonious framework to coordinate cultural differences at the FFE.
MHD natural convective flow of nanofluids past stationary and moving inclined porous plate considering temperature and concentration gradients with suction
Authors: Thumma Thirupathi , Chamkha A. , Sheri Siva Reddy 
Published: July 2017

Purpose
This paper aims to focus on the mathematical modeling of magnetohydrodynamic natural convective boundary layer flow of nanofluids past a stationary and moving inclined porous plate considering temperature and concentration gradients with suction effects.

Design/methodology/approach
The transformed non-dimensional and coupled governing partial differential equations are solved numerically using the finite element method.

Findings
The obtained numerical results for physical governing parameters on the velocity, temperature and concentration distributions are exemplified graphically and presented quantitatively. The boundary layer thickness increased with the increasing values of Soret, Dufour and Grashof numbers, while the thickness of boundary layer decreased with increasing values of suction for both stationary and moving plate cases. The primary and secondary velocity profiles are decreasing with an angle of inclination for moving plate and inclination has no significant effect for the stationary plate. An increase of the Soret number and Dufour number tend to increase the heat and mass transfer, while an increase of suction reduces the heat and mass transfer.

Originality/value
The problem is an important contribution to the field of nanofluid science and technology and is relevant to high temperature rotating chemical engineering systems exploiting magnetized nanofluids. This study is relatively original in nanofluids.
Numerical investigation of heat flux distribution in a deep gap based on chemical equilibrium
Authors: Huang Guo , Huang Haiming 
Published: July 2017

Purpose
The purpose of this paper is to perform the simulation to explore the gap flow field under a hypersonic air flow. Thermal protection systems of hypersonic vehicles generally consist of thermal insulation tiles, and gaps between these tiles probably cause a severe local aerodynamic thermal effect.

Design/methodology/approach
The discretizations of convection flux term and temporal term in the governing equation with chemical equilibrium, respectively, take AUSM+-up flux-vector splitting scheme and the implicit lower-upper symmetric Gauss–Seidel method. Based on these, the flow field in a deep gap is simulated by means of the computer codes that the authors have written.

Findings
The numerical results show that the heat flux distribution in a gap has a good agreement with experimental results. Importantly, the distribution of heat flux is “U” shaped and the maximum of the heat flux occurs at the windward corner of a gap.

Originality/value
To explore the gap flow field under a hypersonic air flow, which is a chemically reacting, all speed and viscous flow, a novel model with an equivalent ratio of specific heats is presented. The investigation in this paper has a guide for the design of the thermal protection system in hypersonic vehicles.
Shock waves analysis of planar and non planar nonlinear Burgers’ equation using Scale-2 Haar wavelets
Authors: Pandit Sapna , Kumar Manoj , Mohapatra R.N. , Alshomrani Ali Saleh 
Published: July 2017

Purpose
This paper aims to find the numerical solution of planar and non-planar Burgers’ equation and analysis of the shock behave.

Design/methodology/approach
First, the authors discritize the time-dependent term using Crank–Nicholson finite difference approximation and use quasilinearization to linearize the nonlinear term then apply Scale-2 Haar wavelets for space integration. After applying this scheme on partial differential, the equation transforms into a system of algebraic equation. Then, the system of equation is solved using Gauss elimination method.

Findings
Present method is the extension of the method (Jiwari, 2012). The numerical solutions using Scale-2 Haar wavelets prove that the proposed method is reliable for planar and non-planar nonlinear Burgers’ equation and yields results better than other methods and compatible with the exact solutions.

Originality/value
The numerical results for non-planar Burgers’ equation are very sparse. In the present paper, the authors identify where the shock wave and discontinuity occur in planar and non-planar Burgers’' equation.