bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suitability of Laurentian Great Lakes for invasive species based on global species distribution models and local habitat
Authors: Kramer Andrew M. , Annis Gust , Wittmann Marion E. , Chadderton William L. , Rutherford Edward S. , Lodge David M. , Mason Lacey , Beletsky Dmitry , Riseng Catherine , Drake John M. 
Published: July 2017

AbstractEfficient management and prevention of species invasions requires accurate prediction of where species of concern can arrive and persist. Species distribution models provide one way to identify potentially suitable habitat by developing the relationship between climate variables and species occurrence data. However, these models when applied to freshwater invasions are complicated by two factors. The first is that the range expansions that typically occur as part of the invasion process violate standard species distribution model assumptions of data stationarity. Second, predicting potential range of freshwater aquatic species is complicated by the reliance on terrestrial climate measurements to develop occurrence relationships for species that occur in aquatic environments. To overcome these obstacles, we combined a recently developed algorithm for species distribution modeling—range bagging—with newly available aquatic habitat‐specific information from the North American Great Lakes region to predict suitable habitat for three potential invasive species: golden mussel, killer shrimp, and northern snakehead. Range bagging may more accurately predict relative suitability than other methods because it focuses on the limits of the species environmental tolerances rather than central tendency or “typical” cases. Overlaying the species distribution model output with aquatic habitat‐specific data then allowed for more specific predictions of areas with high suitability. Our results indicate there is suitable habitat for northern snakehead in the Great Lakes, particularly shallow coastal habitats in the lower four Great Lakes where literature suggests they will favor areas of wetland and submerged aquatic vegetation. These coastal areas also offer the highest suitability for golden mussel, but our models suggest they are marginal habitats. Globally, the Great Lakes provide the closest match to the currently invaded range of killer shrimp, but they appear to pose an intermediate risk to the region. Range bagging provided reliable predictions when assessed either by a standard test set or by tests for spatial transferability, with golden mussel being the most difficult to accurately predict. Our approach illustrates the strength of combining multiple sources of data, while reiterating the need for increased measurement of freshwater habitat at high spatial resolutions to improve the ability to predict potential invasive species.
Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA‐induced human neutrophil activation and migration
Authors: Heineke Marieke H. , van der Steen Lydia P.E. , Korthouwer Rianne M. , Hage J. Joris , Langedijk Johannes P.M. , Benschop Joris J. , Bakema Jantine E. , Slootstra Jerry W. , van Egmond Marjolein 
Published: July 2017

AbstractThe cross‐linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce massive recruitment of neutrophils, resulting in severe tissue damage. To interfere with neutrophil mobilization and reduce disease morbidity, we developed a panel of specific peptides mimicking either IgA or FcαRI sequences. CLIPS technology was used to stabilize three‐dimensional structures and to increase peptides’ half‐life. IgA and FcαRI peptides reduced phagocytosis of IgA‐coated beads, as well as IgA‐induced ROS production and neutrophil migration in in vitro and ex vivo (human skin) experiments. Since topical application would be the preferential route of administration, Cetomacrogol cream containing an IgA CLIPS peptide was developed. In the presence of a skin permeation enhancer, peptides in this cream were shown to penetrate the skin, while not diffusing systemically. Finally, epitope mapping was used to discover sequences important for binding between IgA and FcαRI. In conclusion, a cream containing IgA or FcαRI peptide mimetics, which block IgA‐induced neutrophil activation and migration in the skin may have therapeutic potential for patients with IgA‐mediated blistering skin diseases.
Resveratrol formulated with a natural deep eutectic solvent inhibits active matrix metalloprotease‐9 in hormetic conditions
Authors: Shamseddin Aly , Crauste Céline , Durand Erwann , Villeneuve Pierre , Dubois Gregor , Durand Thierry , Vercauteren Joseph , Veas Francisco 
Published: July 2017

Despite the promising anti‐oxidant and anti‐inflammatory effects of resveratrol (RES) on human health, pre‐clinical and clinical studies are frequently disappointing, probably due to its low water‐solubility and poor bioavailability. Even though a hormetic mode of action was clearly established for RES, the high doses commonly used to mitigate these issues, lead to adverse effects. Common hallmarks of multiple pathologies results from pathological‐enhanced endothelial permeability due to both enhanced inflammation and matrix metalloprotease‐9 (aMMP‐9) activities. The main aim of this work was to optimize the RES capacity to inhibit aMMP‐9 by using a new class of solvents, natural deep eutectic solvents (NADES) for a new RES formulation as compared with dimethyl‐sulfoxide (DMSO). To obtain the appropriate NADES, 18 compounds combinations were prepared to select those exhibiting the optimized capacity to dissolve RES. The RES‐NADES 1,2‐propanediol:choline‐chloride:water (PCW, 1:1:1 molar ratio) and compared with RES‐DMSO for their aMMP‐9‐inhibitory capacities. Low concentrations of RES‐NADES/PCW formulation exhibited both a biocompatible solubility and a strong increased aMMP‐9‐inhibitory activity, at least 10‐fold, higher than RES‐DMSO, reaching its hormetic mode of action. Following in vivo validations, some particular NADES could potentially be considered as the new generation of formulation for druggable compounds.Practical applications: Formulation of resveratrol in Natural Deep Eutectic solvents (NADES) optimizes its capacity to inhibit active matrix metalloprotease‐9. The Resveratrol‐NADES 1,2‐propanediol:choline‐was the most efficient and low concentrations exhibited both a biocompatible solubility and an increased aMMP‐9‐inhibitory activity, at least 10‐fold, higher than RES‐DMSO. Consequently, the NADES/PCW formulation allowed resveratrol to reach its hormetic mode of action. Following in vivo validations, some particular NADES could potentially be considered as the new generation of formulation for druggable compounds.The effect of resveratrol (RES) dissolved in either NADES/PCW or DMSO was assessed on the TNFa‐activated human monocytes (THP‐1). NADES/PCW was able to confer a significant increase of the MMP‐9 inhibitory activity of RES, at low doses (at least 10‐fold higher) than DMSO, Thus, these data on RES‐NADES/PCW formulation support the hormetic effect of resveratrol in preserving the endothelial monolayer integrity by decreasing the exacerbated vascular permeability induced by the overproduction of active MMP‐9, during inflammation resulting from infections, cancer, or other pathologies.
Cost‐efficient deployment of mmW small cells with hybrid backhauls
Authors: Cao Wei , Feng Gang , Qin Shuang , Liang Liang 
Published: July 2017

AbstractHybrid backhaul networks with millimeter wave (mmW) technologies are widely viewed as promising solutions to support next‐generation ultradense mobile networks. In this paper, we propose a cost‐efficient deployment framework of mmW small cells with hybrid backhaul, with the aim of providing useful insights on the optimal deployment of small cells for mmW mobile network planning. We investigate the trade‐off between the deployment cost and the number of user equipments that can be admitted while considering 2 kinds of base stations (BSs) in mmW networks: backhaul aggregate nodes (BANs) and wireless backhaul BSs (WBSs). We derive the deployment cost of mmW networks including BSs and wired backhaul links as a function of the number of BANs and WBSs and investigate the relationship between the number of BSs and the number of admitted user equipments. We formulate an optimization problem to maximize cost efficiency subject to the constraint of wireless backhaul link capacity and derive the optimal number of WBSs per BAN cluster as well as the optimal number of deployed BANs. Numerical results validate the effectiveness of our proposed BS deployment framework.
Cork ‐ a natural material for linalool controlled release
Authors: Sousa Sara , Silva Mário , Gomes Filipa Oliveira , Fernandes Domingues Valentina Maria , Delerue Matos Cristina 
Published: July 2017

AbstractControlled release of aromatic mixtures to the atmosphere is a requirement for scented systems for indoor applications. The product must smell nice, but also be able to last, slowly releasing the perfume over time. Several adsorption materials have been used, for this purpose. In this study, cork was investigated as a potential perfume adsorbent for application in scented drawer sachets and equivalent products. Cork was selected due to its adsorption properties and because it is a natural, renewable, sustainable material. Granulated cork is a significant by‐product in cork industries and it was chosen for adsorption in this work. Linalool, an enantiomeric monoterpene alcohol and one of the main components of several essential oils, was selected as the model compound for adsorption studies.Activated carbon (AC) was used as the reference material. The sorption of linalool to granulated cork and AC was evaluated by HS‐SPME‐GC‐FID. The linalool isotherm on cork was shown to follow a Brunauer‐Deming‐Deming and Teller, Type IV model. The isotherm data on AC can be adjusted to Langmuir and Freundlich models. A maximum adsorption capacity of 3.9x103μg/g was achieved for AC. Desorption studies were performed. Linalool was still released from granulated cork after three equilibrium stages of desorption, whereas only two desorption values were obtained for AC from the equilibrium with highest linalool concentration. Thus, AC demonstrated good adsorption but not good desorption properties. Sorption and desorption studies of linalool from granulated cork, showed that granulated cork could be an excellent material allowing controlled release of the aroma.
Investigation of a Spinel‐forming Cu‐Mn Foam as an Oxygen Electrode Contact Material in a Solid Oxide Cell Single Repeating Unit
Authors: Zielke P. , Wulff A. C. , Sun X. , Jensen S. H. , Kiebach R. , Frandsen H. L. , Norby P. , Hagen A. 
Published: July 2017

AbstractA critical issue in state‐of‐the‐art solid oxide cell stacks is the contacting of the oxygen electrode. The commonly used ceramic contact layers are applied in a green state and cannot be sintered properly, due to compliance limitations arising from other stack components like sealing glasses and steels. The consequence is a low layer and interface strength. A metallic copper manganese foam, which is oxidized under operation conditions into a conductive Cu1+xMn2–xO4 spinel, is presented in this work as a viable contact solution. The foam has been electrochemically tested in a single repeating unit setup for 350 hours of constant operation, followed by dynamic conditions with thermal cycles. After operation, a micro structural analysis using scanning electron microscopy, energy dispersive X‐ray spectroscopy and X‐ray diffraction was carried out. It was confirmed that after oxidation/operation the manganese solely formed a CuMn‐spinel phase, mixed with a CuO phase. A separate Mn‐oxide phase was not found. The conductivity and contacting of the foam was sufficient for > 350 h of SOFC operation. With an initial serial resistance comparable to single cell tests using gold foil as contact material and moderate degradation rates, the CuMn foam presented itself as an interesting cathode contact solution.
Insula‐based networks in professional musicians: Evidence for increased functional connectivity during resting state fMRI
Authors: Zamorano Anna M. , Cifre Ignacio , Montoya Pedro , Riquelme Inmaculada , Kleber Boris 
Published: July 2017

AbstractDespite considerable research on experience‐dependent neuroplasticity in professional musicians, detailed understanding of an involvement of the insula is only now beginning to emerge. We investigated the effects of musical training on intrinsic insula‐based connectivity in professional classical musicians relative to nonmusicians using resting‐state functional MRI. Following a tripartite scheme of insula subdivisions, coactivation profiles were analyzed for the posterior, ventral anterior, and dorsal anterior insula in both hemispheres. While whole‐brain connectivity across all participants confirmed previously reported patterns, between‐group comparisons revealed increased insular connectivity in musicians relative to nonmusicians. Coactivated regions encompassed constituents of large‐scale networks involved in salience detection (e.g., anterior and middle cingulate cortex), affective processing (e.g., orbitofrontal cortex and temporal pole), and higher order cognition (e.g., dorsolateral prefrontal cortex and the temporoparietal junction), whereas no differences were found for the reversed group contrast. Importantly, these connectivity patterns were stronger in musicians who experienced more years of musical practice, including also sensorimotor regions involved in music performance (M1 hand area, S1, A1, and SMA). We conclude that musical training triggers significant reorganization in insula‐based networks, potentially facilitating high‐level cognitive and affective functions associated with the fast integration of multisensory information in the context of music performance. Hum Brain Mapp 38:4834–4849, 2017. © 2017 Wiley Periodicals, Inc.
Neurodevelopmental maturation as a function of irritable temperament
Authors: Karim Helmet T. , Perlman Susan B. 
Published: July 2017

AbstractFew studies have investigated the neural systems involved in decreasing behavioral reactivity to emotional stimuli as children age. It has been suggested that this process may interact with temperament‐linked variations in neurodevelopment to better explain individual differences in the maturation of emotion regulation. In this investigation, children ages 4 to 12 (n = 30, mean age = 7.62 years, SD = 1.71 years) and adults (n = 21, mean age = 26.67 years) watched clips from popular children's films containing positive, negative, or neutral emotional content during functional magnetic resonance imaging. Compared to adults, children demonstrated greater activation in subcortical and visual regions (hippocampus, thalamus, visual cortex, fusiform) during negative clips and greater activation of subcortical and prefrontal regions during positive clips (hippocampus, thalamus, caudate, ACC, OFC, superior frontal cortex). In children only, we found an age by temperament interaction in frontal and subcortical regions indicating that activation increased as a function of age in the most irritable children, but decreased as a function of age in the least irritable children. Findings were not present in the temperament domain of fear. Findings replicate and extend the existing irritability literature, indicating that healthy children highest in irritability may develop comparatively greater activation of the lateral prefrontal cortex in order to support adaptive regulation during emotional challenges. These results are discussed within the context of the emerging literature on the utility of complex, multidimensional, and naturalistic stimuli, which present a complementary alternative to understanding ecologically valid and sustained neural responses to emotionally evocative stimuli.Hum Brain Mapp 38:5307–5321, 2017. ©2017 Wiley Periodicals, Inc.
Mean platelet volume predicts prognosis in patients with diffuse large B‐cell lymphoma
Authors: Zhou Shujuan , Ma Yongyong , Shi Yifen , Tang Liyuan , Zheng Zhouyi , Fang Fang , Feng Jianhua , Zhang Yu , Sun Lan , Chen Yi , Liang Bin , Jiang Songfu , Shen Zhijian , Yu Kang , Wang Siqian 
Published: July 2017

AbstractTo determine the prognostic value of baseline mean platelet volume (MPV) in diffuse large B‐cell lymphoma (DLBCL) patients. We retrospectively analyzed 161 DLBCL patients who received R‐CHOP chemotherapy. The associations between MPV and clinicopathological factors were assessed. A low MPV (MPV ≤ 9.1 fl, cut‐off was calculated by receiver operating characteristics) was not associated with any other clinicopathological factors. Patients with MPV ≤ 9.1 fl experienced a shorter progression‐free survival (PFS) (2‐year PFS rate, 60.6% vs 84.0%, P = 0.003) and overall survival (OS) (2‐year OS rate, 70.4% vs 87.9%, P = 0.030), compared with those with MPV > 9.1 fl. The multivariate analysis demonstrated that MPV ≤ 9.1 fl was an independent prognostic factor of OS (Hazard Ratio [HR] = 0.588, P = 0.045) and PFS (HR = 0.456, P = 0.010). Therefore, we demonstrated that low baseline MPV is an independent prognostic marker of poor outcome in patients with DLBCL.
Solar Wastewater Treatment (SOWAT) and Reuse for Agricultural Irrigation
Authors: Igoud Sadek , Souahi Fatiha , Chitour Chems Eddine 
Published: July 2017

AbstractSolar wastewater treatment (SOWAT) was the subject of experiment between April and September using low cost and mastery equipment: ‘hot‐box’ stills. Using a separate still, treated wastewater (i.e. distillate) production was recorded between 2.4 and 6 l m−2 day−1. Treatment efficiency was comparable to the activated sludge treatment process. Biological oxygen demand (BOD) recorded between 86 and 90% of abatement. Raw wastewater turbidity was reduced by 99%, from 181 nephelometric turbidity units (NTU) to 1.6 NTU. The treatment also allowed wastewater disinfection. The inactivation of total coliforms, faecal coliforms and faecal streptococci was estimated at about 99%.SOWAT offers the advantage of grouping, in a separate piece of equipment, three steps of conventional wastewater treatment: (i) the pre‐treatment, (ii) the biological and (iii) disinfection treatments. Also, this sustainable treatment does not consume electricity and consequently does not emit greenhouse gases (GHGs).Used on a medium and large scale, SOWAT would be promising for safe wastewater reuse in agriculture. This could secure food production of poor and low‐income countries, especially those that are very sunny. Copyright © 2017 John Wiley & Sons, Ltd.
Quantification of Flood Damage under Potential Climate Change Impacts in Central Vietnam
Authors: Van Dau Quan , Kuntiyawichai Kittiwet , Plermkamon Vichian 
Published: July 2017

AbstractThe quantification of economic losses due to floods becomes necessary in flood management. In this context, the study aims to assess insights into flood damage under potential impacts of climate change in central Vietnam. The HadGEM3–RA Regional Climate Model (RCM) under Representative Concentration Pathways (RCP) 4.5 and 8.5 climate change scenarios was used in this study. A bias correction technique for adjusting RCM simulations was applied to correct the climate input data for systematic statistical deviations from observed data. In addition, a coupling of the HEC‐HMS and HEC‐RAS hydrodynamic models and the flood damage reduction analysis model (HEC‐FDA) was applied to assess the level of flood hazard and damage existing in central Vietnam. The findings showed that the weather in central Vietnam will be warmer in the future with the average temperature increasing from 0.2 to 0.8°C, and annual rainfall will increase from 3.5 to 6.8%. The water level and runoff will also increase from 0.1 to 0.3 m and 10–30%, respectively. Flood damage was estimated to be US$18.8–20.7 million from the 2020s to the 2080s. Finally, the findings obtained are useful for the decision‐making process in flood management and economic development in Vietnam. Copyright © 2017 John Wiley & Sons, Ltd.
Improved bacterial identification directly from urine samples with matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
Authors: Kitagawa Koichi , Shigemura Katsumi , Onuma Ken‐ichiro , Nishida Masako , Fujiwara Mayu , Kobayashi Saori , Yamasaki Mika , Nakamura Tatsuya , Yamamichi Fukashi , Shirakawa Toshiro , Tokimatsu Issei , Fujisawa Masato 
Published: July 2017

BackgroundMatrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) contributes to rapid identification of pathogens in the clinic but has not yet performed especially well for Gram‐positive cocci (GPC) causing complicated urinary tract infection (UTI). The goal of this study was to investigate the possible clinical use of MALDI‐TOF MS as a rapid method for bacterial identification directly from urine in complicated UTI.MethodsMALDI‐TOF MS was applied to urine samples gathered from 142 suspected complicated UTI patients in 2015‐2017. We modified the standard procedure (Method 1) for sample preparation by adding an initial 10 minutes of ultrasonication followed by centrifugation at 500 g for 1 minutes to remove debris such as epithelial cells and leukocytes from the urine (Method 2).ResultsIn 133 urine culture‐positive bacteria, the rate of corresponded with urine culture in GPC by MALDI‐TOF MS in urine with standard sample preparation (Method 1) was 16.7%, but the modified sample preparation (Method 2) significantly improved that rate to 52.2% (P=.045). Method 2 also improved the identification accuracy for Gram‐negative rods (GNR) from 77.1% to 94.2% (P=.022). The modified Method 2 significantly improved the average MALDI score from 1.408±0.153 to 2.166±0.045 (P=.000) for GPC and slightly improved the score from 2.107±0.061 to 2.164±0.037 for GNR.ConclusionThe modified sample preparation for MALDI‐TOF MS can improve identification accuracy for complicated UTI causative bacteria. This simple modification offers a rapid and accurate routine diagnosis for UTI, and may possibly be a substitute for urine cultures.
Dental pulp stem cells and the management of neurological diseases: An update
Authors: Mortada Ibrahim , Mortada Rola , Al Bazzal Mohamad 
Published: July 2017

AbstractMedical research in regenerative medicine has brought promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive source of these cells since collecting mesenchymal stem cells from this site is a noninvasive practice that can be performed after a common surgical extraction of supernumerary or wisdom teeth. Thus, tissue sacrifice is very low and several cytotypes can be obtained owing to these cells' multipotency, in addition to the fact that they can be cryopreserved and stored for long periods. Mesenchymal stem cells have high proliferation rates, making them favorable for clinical application. These multipotent cells, present in biological waste, constitute an appropriate resource in the treatment of many neurological diseases.