bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of interfractional variation of the centroid position and volume of internal target volume during stereotactic body radiotherapy of lung cancer using cone‐beam computed tomography
Authors: Sun Yanan , Ge Hong , Cheng Siguo , Yang Chengliang , Zhu Qianqian , Li Dingjie , Tian Yuan 
Published: February 2017

The purpose of this study was to determine interfractional variation of the centroid position and volume of internal target volume (ITV) during stereotactic body radiation therapy (SBRT) of lung cancer. From January 2014 to August 2014, a total of 32 patients with 37 primary or metastatic lung tumors were enrolled in our study. All patients received SBRT treatment in 4–5 fractions to a median dose of 48 Gy. Both 3D CT and 4D CT scans were used for radiotherapy treatment planning. 3D CBCT was acquired prior to treatment delivery to verify patient positioning. A total of 163 3D CBCT images were available for evaluation. 3D CBCT scans acquired for verification were registered with simulation CT scans. The ITVs were contoured on all verification 3D CBCT scans and compared to the initial gross target volume (GTV) or ITV in treatment planning system. GTV was based on 3D CT while ITV was based on both 3D CT and 4D CT. To assess the interfractional variation of ITV centroid position, we used vertebrae body adjacent to the tumor as reference point when performing the registration procedure. To eliminate the effect of time on tumor volume between simulation CT scan and the first fraction, the interfractional variation of ITV was evaluated from the first fraction to the last fraction. The overall 3D vector shift was (range: ). The interfractional variation of ITV centroid position in superior‐inferior, anterior‐posterior, and left‐right directions were , , and , respectively. No significant difference was observed between three directions (). Large interfractional variations () were observed in 12 fractions (9.3%) in superior‐inferior direction, 24 fractions (18.6%) in anterior‐posterior direction, and 5 fractions (3.9%) in left‐right direction. No time trend of tumor volume change measured in 3D CBCT was detected during four fractions (). A significant () time trend was detected when evaluating the time trend of ITV change during 5 fractions and diameter was found to be significantly correlated with the ITV change (). ITV did not show significant regression during SBRT treatment, but interfractional variation in the ITV centroid position was observed, especially in anterior‐posterior direction. An isotropic margin of 7 mm around ITV might be necessary for adequate coverage of interfractional variation of ITV centroid position, but only in case no soft tissue‐based setup is performed during SBRT treatment.PACS number(s): 87.55.dk
Implementation of full/half bowtie filter models in a commercial treatment planning system for kilovoltage cone‐beam CT dose estimations
Authors: Kim Sangroh , Alaei Parham 
Published: February 2017

The purpose of this study was to implement full/half bowtie filter models in a commercial treatment planning system (TPS) to calculate kilovoltage (kV) cone‐beam CT (CBCT) doses of Varian On‐Board Imager (OBI) kV X‐ray imaging system. The full/half bowtie filter models were created as compensators in Pinnacle TPS using MATLAB software. The physical profiles of both bowtie filters were imported and hard‐coded in the MATLAB system. Pinnacle scripts were written to import bowtie filter models into Pinnacle treatment plans. Bowtie filter‐free kV X‐ray beam models were commissioned and the bowtie filter models were validated by analyzing the lateral and percent‐depth‐dose (PDD) profiles of anterior/posterior X‐ray beams in water phantoms. A CT dose index (CTDI) phantom was employed to calculate CTDI and weighted CTDI values for pelvis and pelvis‐spotlight CBCT protocols. A five‐year‐old pediatric anthropomorphic phantom was utilized to evaluate absorbed and effective doses (ED) for standard and low‐dose head CBCT protocols. The CBCT dose calculation results were compared to ion chamber (IC) and Monte Carlo (MC) data for the CTDI phantom and MOSFET and MC results for the pediatric phantom, respectively. The differences of lateral and PDD profiles between TPS calculations and IC measurements were within 6%. The CTDI and weighted CTDI values of the TPS were respectively within 0.25 cGy and 0.08 cGy compared to IC measurements. The absorbed doses ranged from 0 to 7.22 cGy for the standard dose CBCT and 0 to 1.56 cGy for the low‐dose CBCT. The ED values were found to be 36‐38 mSv and 7‐8 mSv for the standard and low‐dose CBCT protocols, respectively. This study demonstrated that the established full/half bowtie filter beam models can produce reasonable dose calculation results. Further study is to be performed to evaluate the models in clinical situations.PACS number(s): 87.57.uq
In vivo MR spectroscopy using 3 Tesla to investigate the metabolic profiles of joint fluids in different types of knee diseases
Authors: Jin Wook , Woo Dong‐Cheol , Jahng Geon‐Ho 
Published: February 2017

In vivo proton () magnetic resonance spectroscopy (MRS) has not yet been systematically used to study joint fluids in human knees. The objective of this study, therefore, was to assess the ability of proton MRS to identify the apparent heterogeneous characteristics of metabolic spectra in the joint fluid regions in human knees using a high‐field MRI system. Eighty‐four patients with effusion lesions who were referred for routine knee MR imaging underwent proton MRS with point‐resolved, single‐voxel MR spectroscopy using a clinical 3.0 Tesla MRI system. Thirty‐eight patients were confirmed to have the following: degenerative osteoarthritis, 21 patients (Group 1); traumatic diseases, 12 patients (Group 2); infectious diseases, 4 patients and an inflammatory disease, 1 patient (Group 3). Spectroscopy data were analyzed using the public jMRUI freeware software to obtain lipid metabolites. Nonparametric statistical comparisons were performed to investigate any differences in metabolites among the three disease groups. The major metabolites were vinylic lipids around , lipids around , and lipids around . Each patient had either a lipid peak, and lipid peaks, or all three peaks. There were no significant differences among the three groups for the (), (), and lipids () and water (); none of the metabolites could differentiate between any of the three types of diseases. The lipids in the 38 patients who had confirmed fluid characteristics were significantly correlated with lipids (, ). The ratio of to was highest in the degenerative disease. In both the degenerative and traumatic diseases, metabolite peaks of the vinylic lipids around and of the sum of the and lipids around were observed, but in the infectious disease, only a metabolite peak of the sum of the and lipids was detected. Although none of the metabolites could statistically significantly differentiate between the three types of diseases, the different lipid metabolite peaks and their ratios in the three disease groups may give us a hint at the different mechanisms of joint fluids in the infectious, degenerative, and traumatic diseases.PACS number(s): 87.61.Ff, 33.25.+k, 87.14.Cc
Comparison of surface matching and target matching for image‐guided pelvic radiation therapy for both supine and prone patient positions
Authors: Zhao Hui , Wang Brian , Sarkar Vikren , Rassiah‐Szegedi Prema , Huang Y. Jessica , Szegedi Martin , Huang Long , Gonzalez Victor , Salter Bill 
Published: February 2017

We investigate the difference between surface matching and target matching for pelvic radiation image guidance. The uniqueness of our study is that all patients have multiple CT‐on‐rails (CTOR) scans to compare to corresponding AlignRT images. Ten patients receiving pelvic radiation were enrolled in this study. Two simulation CT scans were performed in supine and prone positions for each patient. Body surface contours were generated in treatment planning system and exported to AlignRT to serve as reference images. During treatment day, the patient was aligned to treatment isocenter with room lasers, and then scanned with both CTOR and AlignRT. Image‐guidance shifts were calculated for both modalities by comparison to the simulation CT and the differences between them were analyzed for both supine and prone positions, respectively. These procedures were performed for each patient once per week for five weeks. The difference of patient displacement between AlignRT and CTOR was analyzed. For supine position, five patients had an average difference of displacement between AlignRT and CTOR along any direction (vertical, longitudinal, and lateral) greater than 0.5 cm, and one patient greater than 1 cm. Four patients had a maximum difference greater than 1 cm. For prone position, seven patients had an average difference greater than 0.5 cm, and three patients greater than 1 cm. Nine patients had a maximum difference greater than 1 cm. The difference of displacement between AlignRT and CTOR was greater for the prone position than for the supine position. For the patients studied here, surface matching does not appear to be an advisable image‐guidance approach for pelvic radiation therapy for patients with either supine or prone position. There appears to be a potential for large alignment discrepancies (up to 2.25 cm) between surface matching and target matching.PACS number(s): 87.55.‐x
An evaluation of organ dose modulation on a GE optima CT660‐computed tomography scanner
Authors: Dixon Matthew T. , Loader Robert J. , Stevens Gregory C. , Rowles Nick P. 
Published: February 2017

Organ Dose Modulation or ODM (GE Healthcare, Milwaukee, WI) was evaluated to characterize changes in , image noise, effective dose, and organ dose saving to patients. Three separate investigations were completed: a tube current modulation phantom was scanned with and without ODM, a phantom was scanned with ODM, and Monte Carlo simulations were performed. ODM was found to reduce the by approximately 20% whilst increasing the noise by approximately 14%. This was reflected in the dose distribution, where the anterior peripheral dose was reduced by approximately 40% whilst the identical posterior dose remained largely unaffected. Enabling ODM for the entire scan would reduce the effective dose by approximately 24%; however, this saving reduces to 5% if the images are matched for . These savings mostly originated from reductions in dose to the stomach, breasts, colon, bladder, and liver. ODM has the effect of a global reduction in with an associated increase in image noise. The benefit of ODM was found to be reduced when the dose‐saving contribution from the reduced was removed. Given that there is a higher contribution to effective dose throughout the body from the anterior projections, consideration should be given to applying ODM throughout.PACS number(s): 87.10.Rt, 87.53.Bn, 87.57.C‐, 87.57.Q‐
Image texture and radiation dose properties in CT
Authors: Mozejko Dawid , Andersen Hilde Kjernlie , Pedersen Marius , Waaler Dag , Martinsen Anne Catrine Trægde 
Published: February 2017

The aim of this study was to compare image noise properties of GE Discovery HD 750 and Toshiba Aquilion ONE. The uniformity section of a Catphan 600 image quality assurance phantom was scanned with both scanners, at different dose levels and with extension rings simulating patients of different sizes. 36 datasets were obtained and analyzed in terms of noise power spectrum. All the results prove that introduction of extension rings significantly altered the image quality with respect to noise properties. Without extension rings, the Toshiba scanner had lower total visible noise than GE (with GE as reference: FC18 had 82% and FC08 had 80% for 10 mGy, FC18 had 77% and FC08 74% for 15 mGy, FC18 had 80% and FC08 77% for 20 mGy). The total visible noise (TVN) for 20 and 15 mGy were similar for the phantom with the smallest additional extension ring, while Toshiba had higher TVN than GE for the 10 mGy dose level (120% FC18, 110% FC08). For the second and third ring, the GE images had lower TVN than Toshiba images for all dose levels (Toshiba TVN is greater than 155% for all cases). The results indicate that GE potentially has less image noise than Toshiba for larger patients. The Toshiba FC18 kernel had higher TVN than the Toshiba FC08 kernel with additional beam hardening correction for all dose levels and phantom sizes (120%, 107%, and 106% for FC18 compared to 110%, 98%, and 97%, for FC08, for 10, 15 and 20 mGy doses, respectively).PACS number(s): 87.57.Q‐, 87.57.nf, 87.57.C‐
Radiation doses and estimated risk from angiographic projections during coronary angiography performed using novel flat detector
Authors: Varghese Anna , Livingstone Roshan S. , Varghese Lijo , Kumar Parveen , Srinath Sirish Chandra , George Oommen K. , George Paul V. 
Published: February 2017

Coronary angiography (CA) procedure uses various angiographic projections to elicit detailed information of the coronary arteries with some steep projections involving high radiation dose to patients. This study intends to evaluate radiation doses and estimated risk from angiographic projections during CA procedure performed using novel flat detector (FD) system with improved image processing and noise reduction techniques. Real‐time monitoring of radiation doses using kerma‐area product (KAP) meter was performed for 140 patients using Philips Clarity FD system. The CA procedure involved seven standard projections, of which five were extensively selected by interventionalists. Mean fluoroscopic time (FT), KAP, and reference air kerma (Ka,r) for CA procedure were 3.24 min (0.5–10.51), 13.99 Gycm2 (4.02–37.6), and 231.43 mGy (73.8–622.15), respectively. Effective dose calculated using Monte Carlo‐based PCXMC software was found to be 4.9 mSv. Left anterior oblique (LAO) 45° projection contributed the highest radiation dose (28%) of the overall KAP. Radiation‐induced risk was found to be higher in females compared to males with increased risk of lung cancer. An increase of 10%–15% in radiation dose was observed when one or more additional projections were adopted along with the seven standard projections. A 14% reduction of radiation dose was achieved from novel FD system when low‐dose protocol during fluoroscopy and medium‐dose protocol during cine acquisitions were adopted, compared to medium‐dose protocol.PACS number(s): 87.50.cm, 87.55.de, 87.55.N, 87.59.cf, 87.59.Dj
Assessment of diffusion tensor image quality across sites and vendors using the American College of Radiology head phantom
Authors: Wang Zhiyue J. , Seo Youngseob , Babcock Evelyn , Huang Hao , Bluml Stefan , Wisnowski Jessica , Holshouser Barbara , Panigrahy Ashok , Shaw Dennis W.W. , Altman Nolan , McColl Roderick W. , Rollins Nancy K. 
Published: February 2017

The purpose of this study was to explore the feasibility of assessing quality of diffusion tensor imaging (DTI) from multiple sites and vendors using American College of Radiology (ACR) phantom. Participating sites (Siemens , GE , and Philips ) reached consensus on parameters for DTI and used the widely available ACR phantom. Tensor data were processed at one site. and eddy current distortions were assessed using grid line displacement on phantom Slice 5; signal‐to‐noise ratio (SNR) was measured at the center and periphery of the image; fractional anisotropy (FA) and mean diffusivity (MD) were assessed using phantom Slice 7. Variations of acquisition parameters and deviations from specified sequence parameters were recorded. Nonlinear grid line distortion was higher with linear shimming and could be corrected using the 2nd order shimming. Following image registration, eddy current distortion was consistently smaller than acquisition voxel size. SNR was consistently higher in the image periphery than center by a factor of 1.3–2.0. ROI‐based FA ranged from 0.007 to 0.024. ROI‐based MD ranged from to . Two sites had image void artifacts. The ACR phantom can be used to compare key quality measures of diffusion images acquired from multiple vendors at multiple sites.PACS number(s): 87.57.‐s, 87.19.lf
In‐house quality check of external beam plans using 3D treatment planning systems — a DVH comparison
Authors: Kumar Ayyalasomayajula Anil , Akula Roopa Rani , Ayyangar Komanduri , Krishna Reddy P. , Vuppu Srinivas , Narayana P. V. Lakshmi , Rao A. Durga Prasada 
Published: February 2017

This paper presents a new approach towards the quality assurance of external beam plans using in‐house‐developed DICOM import and export software in a clinical setup. The new approach is different from what is currently used in most clinics, viz., only MU and point dose are verified. The DICOM‐RT software generates ASCII files to import/export structure sets, treatment beam data, and dose‐volume histograms (DVH) from one treatment planning system (TPS) to the other. An efficient and reliable 3D planning system, ROPS, was used for verifying the accuracy of treatment plans and treatment plan parameters. With the use of this new approach, treatment plans planned using Varian Eclipse planning system were exported to ROPS planning system. Important treatment and dosimetrical data, such as the beam setup accuracy, target dose coverage, and dose to critical structures, were also quantitatively verified using DVH comparisons. Two external beam plans with diverse photon energies were selected to test the new approach. The satisfactory results show that the new approach is feasible, easy to use, and can be used as an adjunct test for patient treatment quality check.PACS number(s): 87.55.dk, 87.55.D‐, 87.55.Qr
Impact of small MU/segment and dose rate on delivery accuracy of volumetric‐modulated arc therapy (VMAT)
Authors: Huang Long , Zhuang Tingliang , Mastroianni Anthony , Djemil Toufik , Cui Taoran , Xia Ping 
Published: February 2017

Volumetric‐modulated arc therapy (VMAT) plans may require more control points (or segments) than some of fixed‐beam IMRT plans that are created with a limited number of segments. Increasing number of control points in a VMAT plan for a given prescription dose could create a large portion of the total number of segments with small number monitor units (MUs) per segment. The purpose of this study is to investigate the impact of the small number MU/segment on the delivery accuracy of VMAT delivered with various dose rates. Ten patient datasets were planned for hippocampus sparing for whole brain irradiation. For each dataset, two VMAT plans were created with maximum dose rates of 600 MU/min (the maximum field size of ) and 1000 MU/min (the maximum field size of ) for a daily dose of 3 Gy. Without reoptimization, the daily dose of these plans was purposely reduced to 1.5 Gy and 1.0 Gy while keeping the same total dose. Using the two dose rates and three different daily doses, six VMAT plans for each dataset were delivered to a physical phantom to investigate how the changes of dose rate and daily doses impact on delivery accuracy. Using the gamma index, we directly compared the delivered planar dose profiles with the reduced daily doses (1.5 Gy and 1.0 Gy) to the delivered planar dose at 3 Gy daily dose, delivered at dose rate of 600 MU/min and 1000 MU/min, respectively. The average numbers of segments with were , for VMAT‐600 1.5 Gy, VMAT‐600 1 Gy plans, and and for VMAT‐1000 1.5 Gy and VMAT‐1000 1 Gy plans, respectively. When delivered at 600 MU/min dose rate, the average gamma index passing rates (1%/1 mm criteria) of comparing delivered 1.5 Gy VMAT planar dose profiles to 3.0 Gy VMAT delivered planar dose profiles was , and the average gamma index passing rate of comparing delivered 1.0 Gy VMAT planar dose to 3.0 Gy VMAT delivered planar dose was . If using 2%/2 mm and 3%/3 mm criteria, the gamma index passing rates were greater than 97% for both 1.5 Gy VMAT and 1.0 Gy VMAT delivered planar doses. At 1000 MU/min dose rate, the average gamma index passing rates were for 1.5 Gy VMAT planar dose profiles and for 1.0 Gy VMAT planar dose profiles when compared to the 3.0 Gy VMAT planar delivered dose profile. When using 2%/2 mm and 3%/3 mm criteria, the gamma index passing rates were greater than 93% for both 1.5 Gy VMAT and 1.0 Gy VMAT planar delivered dose. Under a stricter gamma index criterion (1%/1 mm), significant differences in delivered planar dose profiles at different daily doses were detected, indicating that the known communication delay between the MU console and MLC console may affect VMAT delivery accuracy.PACS number(s): 87.56.bd, 87.55.‐x
Biplane interventional pediatric system with cone‐beam CT: dose and image quality characterization for the default protocols
Authors: Corredoira Eva , Vañó Eliseo , Alejo Luis , Ubeda Carlos , Gutiérrez‐Larraya Federico , Garayoa Julia 
Published: February 2017

The aim of this study was to assess image quality and radiation dose of a biplane angiographic system with cone‐beam CT (CBCT) capability tuned for pediatric cardiac procedures. The results of this study can be used to explore dose reduction techniques. For pulsed fluoroscopy and cine modes, polymethyl methacrylate phantoms of various thicknesses and a Leeds TOR 18‐FG test object were employed. Various fields of view (FOV) were selected. For CBCT, the study employed head and body dose phantoms, Catphan 504, and an anthropomorphic cardiology phantom. The study also compared two 3D rotational angiography protocols. The entrance surface air kerma per frame increases by a factor of 3–12 when comparing cine and fluoroscopy frames. The biggest difference in the signal‐to‐noise ratio between fluoroscopy and cine modes occurs at FOV 32 cm because fluoroscopy is acquired at a pixel matrix size and in unbinned mode, whereas cine is acquired at pixels and in binned mode. The high‐contrast spatial resolution of cine is better than that of fluoroscopy, except for FOV 32 cm, because fluoroscopy mode with 32 cm FOV is unbinned. Acquiring CBCT series with a 16 cm head phantom using the standard dose protocol results in a threefold dose increase compared with the low‐dose protocol. Although the amount of noise present in the images acquired with the low‐dose protocol is much higher than that obtained with the standard mode, the images present better spatial resolution. A 1 mm diameter rod with 250 Hounsfield units can be distinguished in reconstructed images with an 8 mm slice width. Pediatric‐specific protocols provide lower doses while maintaining sufficient image quality. The system offers a novel 3D imaging mode. The acquisition of CBCT images results in increased doses administered to the patients, but also provides further diagnostic information contained in the volumetric images. The assessed CBCT protocols provide images that are noisy, but with very good spatial resolution.PACS number(s): 87.59.‐e, 87.59.‐C, 87.59.‐cf, 87.59.Dj, 87.57. uq