bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aktivitas Antioksidan Beberapa Tumbuhan Obat Kalimantan Timur
Authors: Herman Herman 
Published: June 2017

Telah dilakukan penelititan dengan judul analisis aktivitas antioksidan terhadap beberapa tumbuhan Kalimantan Timur yang dianggap sebagai obat. Penelitian ini bertujuan untuk mengidentifikasi golongan metabolit sekunder yang terkandung dalam ekstrak dan menguji aktivitas antioksidan. Metode yang digunakan untuk mengidentifikasi golongan metabiolit sekunder dilakukan dengan penambahan reagen kimia sedangkan untuk menetahui aktivitas antioksidan dengan metode peredaman radikal bebas DPPH terhadap ekstrak dan fraksi menggunakan spektofotometer UV-Visible dengan panjang gelombang 517 nm. Hasil identifikasi golongan metabolit sekunder menunjukkan bahwa dari keempat jenis tumbuhan teridentifikasi mengandung golongan senyawa alkaloid, fenol, saponin, dan tanin serta aktivitas antioksidan dengan nilai IC50 dari ekstrak kasar maupun fraksi terbaiknya dibawah 100 ppm.
Kata Kunci: Antioksidan, Ageratum conyzoides L., Captosapelta Tomentosa V., Lepisanthes amoena, Acanthus ilicifolius L., DPPH

ABSTRACT
Study with the title analysis of antioxidant activity against several plants east Kalimantan are considered as a drug. Study aims to identify the class of secondary metabolites contained in extracts and tested the antioxidant activity. The method used to identify the class of secondary metabolites made by the addition of chemical reagents and to determine the antioxidant activity by the DPPH free radical reduction method to extract and fractions using UV-Visible spectrophotometer with a wavelength of 517 nm. The identification results showed that the class of secondary metabolites from plants identified four classes of compounds contains alkaloids, phenols, saponins and tannins and antioxidant activity with the best IC50 values of crude extract and fractions below 100 ppm.
Key Words: Antioxidant, Ageratum conyzoides L., Captosapelta Tomentosa V., Lepisanthes amoena, Acanthus ilicifolius L., DPPH
Efek Hemostatis Ekstrak Metanol Daun Sisik Naga (Drymoglossum Piloselloides Presl.) pada Tikus Jantan (Rattus norvegicus L.)
Authors: Rahayu Ika , Kuncoro Hadi , Ibrahim Arsyik 
Published: June 2017

The research is The Hemostatic Effect of Sisik Naga Leaves (Drymoglossum Piloselloides Presl.) Metanol Extract of Rat (Rattus norvegicus L.) has been done. This reseachâ€™s purposes to determine the hemostatic effect, optimum dose and optimum measured time of Sisik Naga Leaves extract with bleeding time as its parameter used tail bleeding. Dose of Sisik Naga extract are 12.5 mg/kgBW, 25 mg/kgBW, and 50 mg/kgBW and NaCMC has been used as negative control, they were given twice a day in one day treatment. Tail bleeding by cutting the ratâ€™s tail has been done on 12th, 24th, and 36th hour after the treatment. The result data was analyzed with two way Analysis of Varian (Anava) and followed BNJD test. The test results showed that bleeding time of negative control NaCMC is 143.15 seconds and bleeding time of Sisik Naga leaves extract with dose 12.5 mg/kgBW on 12th hours 82.62 second, 24th hours 60.27 second, 36th hours 76.36 second, dose 25 mg/kgBW on 12th hours 65.76 second, 24th hours 39.33 second, 36th hours 90.02 second, and dose 50 mg/kgBW on 12th hours 53.97 second, 24th hours 23.82 second, 36th hours 72.85. The best dose which optimum effect of hemostatic is 50 mg/kgBW with measured time on 24 hours after orally extract.
Keyword : hemostatic, Drymoglossum Piloselloides Presl., bleeding time

Abstrak
Telah dilakukan penelitian efek hemostatis ekstrak metanol daun Sisik Naga (Drymoglossum Piloselloides Presl.) pada tikus jantan (Rattus norvegicus L.). Penelitian ini bertujuan untuk mengetahui efek hemostatis, dosis dan waktu pengukuran optimum ekstrak Sisik Naga dengan mengukur waktu perdarahan pada tikus menggunakan metode tail bleeding. Dosis uji ekstrak daun Sisik Naga yang digunakan adalah 12,5 mg/kgBB, 25 mg/kgBB dan 50 mg/kgBB dengan kontrol negatif NaCMC yang diberikan per oral dua kali sehari selama satu hari. Pengukuran waktu perdarahan adalah 12 jam, 24 jam dan 36 jam setelah pemberian ekstrak. Data dianalisis dengan Anava dua arah yang dilanjutkan dengan uji lanjutan BNJD. Hasil penelitian menunjukkan bahwa rata-rata waktu perdarahan kontrol negatif NaCMC adalah 143,15 detik dan rata-rata waktu perdarahan ekstrak daun Sisik Naga pada dosis 12,5 mg/kgBB pada 12 jam 82,62 detik, 24 jam 60,27 detik, 36 jam 76,36 detik, dosis 25 mg/kgBB pada 12 jam 65,76 detik, 24 jam 39,33 detik, 36 jam 90,02 detik, dan dosis 50 mg/kgBB 12 jam 53,97 detik, 24 jam 23,82 detik, 36 jam 72,85 detik. Dosis yang paling efektif sebagai hemostatis adalah pada dosis 50 mg/kgBB dengan waktu pengukuran yang paling efektif yaitu 24 jam setelah pemberian ekstrak.
Kata kunci : Hemostatis, Drymoglossum Piloselloides Presl., waktu perdarahan
Aktivitas Antibakteri Ekstrak Daun Kecapi (Sandoricum koetjape Merr.)
Authors: Hardika P.A.N Pindo , Fridayanti Aditya , Rijai Laode 
Published: June 2017

A research has been conducted on the antibacterial activity of the santol leaves extract (S.koetjape Merr.) against S.aureus and E.coli. The santol leaves extracts were prepared by maceration used methanol as solvent and the methanol extract was then fractionated. The antibacterial activity was determined by measured the diameter of inhibition zones in difusi method. The result showed that santol leaves extracts and fractions has antibacterial activity against S.aureus and E.coli. The effective concentration as an antibacterial of methanol extracts is at 10%, and of n-hexane fractions is at 5%.
Keywords : S.koetjape Merr, Santol leaves, Antibacteria

Abstrak
Telah dilakukan penelitian uji aktivitas antibakteri ekstrak daun kecapi (S.koetjape Merr.) terhadap S.aureus dan E.coli. Ekstrak daun kecapi dibuat secara maserasi dengan pelarut metanol, lalu difraksinasi. Uji aktivitas antibakteri ekstrak daun kecapi diukur berdasarkan luas daerah zoa bunuh pertumbuhan bakteri dengan metode difusi agar. Hasil uji menunjukkan bahwa ekstrak dan fraksi daun kecapi memiliki aktivitas antibakteri terhadap bakteri S.aureus dan E.coli. Konsentrasi efektif antibakteri ekstrak metanol adalah 10% dan fraksi n-heksana adalah 5%.
Kata Kunci : S.koetjape Merr, Daun Kecapi, Antibakteri
Molecular Clouds in the Extreme Outer Galaxy between l = 34.°75 to 45.°25
Authors: Sun Yan , Su Yang , Zhang Shao-Bo , Xu Ye , Chen Xue-Peng , Yang Ji , Jiang Zhi-Bo , Fang Min 
Published: June 2017

Abstract
We present the results of an unbiased CO survey in the Galactic range of 34.°75 ≤ l ≤ 45.°25 and −5.°25 ≤ b ≤ 5.°25, and the velocity range beyond the Outer arm. A total of 168 molecular clouds (MCs) are identified within the Extreme Outer Galaxy (EOG) region, and 31 of these MCs are associated with 13CO emission. However, none of them show significant C18O emission under the current detection limit. The typical size and mass of these MCs are 5 pc and 3 × 103
M
⊙, implying a lack of large and massive MCs in the EOG region. Similar to MCs in the outer Galaxy, the velocity dispersions of EOG clouds are also correlated with their sizes; however, they are well displaced below the scaling relationship defined by the inner Galaxy MCs. These MCs with a median Galactocentric radius of 12.6 kpc show very different distributions from those of the MCs in the Outer arm published in our previous paper, while roughly following the Outer Scutum–Centaurus arm defined by Dame & Thaddeus. This result may provide robust evidence for the existence of the Outer Scutum–Centaurus arm. The lower limit of the total mass of this segment is about 2.7 × 105
M
⊙, which is about one magnitude lower than that of the Outer arm. The mean thickness of the gaseous disk is about 1.°45 or 450 pc, and the scale height is about 1.°27, or 400 pc above the b = 0° plane. The warp traced by CO emission is very obvious in the EOG region and its amplitude is consistent with the predictions by other warp models using different tracers, such as dust, H i, and stellar components of our Galaxy.
An Empirical Template Library of Stellar Spectra for a Wide Range of Spectral Classes, Luminosity Classes, and Metallicities Using SDSS BOSS Spectra
Authors: Kesseli Aurora Y. , West Andrew A. , Veyette Mark , Harrison Brandon , Feldman Dan , Bochanski John J. 
Published: June 2017

Abstract
We present a library of empirical stellar spectra created using spectra from the Sloan Digital Sky Survey’s Baryon Oscillation Spectroscopic Survey. The templates cover spectral types O5 through L3, are binned by metallicity from −2.0 dex through +1.0 dex, and are separated into main-sequence (dwarf) stars and giant stars. With recently developed M dwarf metallicity indicators, we are able to extend the metallicity bins down through the spectral subtype M8, making this the first empirical library with this degree of temperature and metallicity coverage. The wavelength coverage for the templates is from 3650 to 10200 Å at a resolution of better than R ∼ 2000. Using the templates, we identify trends in color space with metallicity and surface gravity, which will be useful for analyzing large data sets from upcoming missions like the Large Synoptic Survey Telescope. Along with the templates, we are releasing a code for automatically (and/or visually) identifying the spectral type and metallicity of a star.
Jim, le magicien aux failles narcissiques et identitaires précoces
Authors: Viodé Christelle 
Published: June 2017

La cure de l’enfant en souffrance ne peut pas se penser sans la présence du corps de l’analyste et sans sa malléabilité afin d’accueillir le corps de tout sujet en souffrance, parfois indomptable, aux prises avec ses terreurs et ses fureurs. Ainsi, à travers cet article nous voulons montrer comment les traumatismes vécus par un enfant dès son plus jeune âge s’expriment à la fois sur la scène de son corps, sur la scène du corps de l’analyste et aussi sur la scène de leur espace commun créé par la rencontre de leur scène corporelle et psychique. Ce travail s’inscrit également dans un axe de réflexions relatives aux enjeux des filiations adoptives, au corps et à la narration possible et consécutive à des traumatismes précoces s’exprimant alors par des scénarios corporels précoces malgré la présence d’un langage bien établi.
The Experience of Teaching Online in Nursing Education
Authors: Gazza Elizabeth A. 
Published: June 2017

Background:
Online education has become a key instructional delivery method in nursing education; however, limited understanding exists about what it is like to teach online. The aim of this study was to uncover the experience of teaching online in nursing education.

Method:
The sample for this phenomenological study included 14 nursing faculty who completed at least 50% of their teaching workload assignment in fully online courses in baccalaureate, master's, or doctoral nursing programs. Data were collected through the use of a demographic questionnaire and personal interviews.

Results:
Four themes emerged from the data: (a) Looking at a Lot of Moving Parts, (b) Always Learning New Things, (c) Going Back and Forth, and (d) Time Is a Blessing and a Curse.

Conclusion:

Online teaching in nursing education differs from traditional classroom teaching in a variety of ways. Policies and guidelines that govern faculty teaching should encompass the identified intricacies of online teaching. [
J Nurs Educ.
2017;56(6):343–349.]
Implantation of Implantable Collamer Lenses After Radial Keratotomy
Authors: Martín-Escuer Bárbara , Alfonso José F. , Esteve-Taboada José J. , Fernández-Vega Cueto Luis , Montés-Micó Robert 
Published: June 2017

PURPOSE:
To assess the predictability, efficacy, and safety of posterior chamber phakic implantable collamer lens (ICL) implantation after radial keratotomy.

METHODS:
In a retrospective non-comparative interventional case series, outcomes in 6 consecutive eyes of 4 patients with residual refraction after radial keratotomy were analyzed after the implantation of ICLs. All of the lenses were implanted to correct the residual refractive error, ranging from −12.00 to +3.50 diopters (D) for sphere and from −0.75 to −3.75 D for cylinder.

RESULTS:
The mean uncorrected distance visual acuity after ICL implantation was 0.31 ± 0.36 logMAR and the corrected distance visual acuity was 0.12 ± 0.10 logMAR. The mean efficacy index was 0.86. No eyes lost lines of visual acuity, two eyes did not change after surgery, two eyes gained one line, and two eyes gained two lines. The mean safety index was 1.17. No intraoperative complications were found and ICL explantation or repositioning was not required during the follow-up. No cases of cataract, pigment dispersion glaucoma, pupillary block, or other vision-threatening complications were found.

CONCLUSIONS:
ICL implantation may be considered a reasonable surgical procedure for correcting residual refractive errors after radial keratotomy.

[
J Refract Surg.
2017;33(6):395–398.]
Crucial Role for Immune Complexes but Not FcRn in Immunization against Anti–TNF-α Antibodies after a Single Injection in Mice
Authors: Arnoult Christophe , Brachet Guillaume , Cadena Castaneda Diana , Azzopardi Nicolas , Passot Christophe , Desvignes Celine , Paintaud Gilles , Heuzé-Vourc’h Nathalie , Watier Hervé , Gouilleux-Gruart Valérie 
Published: June 2017

Abstract
The immunogenicity of infliximab and adalimumab is a major concern because patients may develop Abs also called antidrug Abs (ADA), directed against these anti–TNF-α Abs after just a few weeks of treatment. These ADAs can lead to a decrease in biologic concentration, which is associated with lower treatment efficacy. Our aim was to study the involvement of immune complexes and neonatal Fc receptor (FcRn) in the emergence of ADAs in the case of anti–TNF-α Abs. Wild type and FcRn knockout mice were injected once with either infliximab or adalimumab, alone or preincubated with TNF-α. Adalimumab cross-reacts with murine TNF-α whereas infliximab is species specific. When injected alone, only adalimumab elicited a humoral response. By preforming immune complexes with TNF-α, an anti-infliximab response was elicited. Surprisingly, both wild type and FcRn knockout mice were able to mount an immune response against anti–TNF-α Abs, suggesting that immune complexes are a major determinant of this immunization.
Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers
Authors: Bird Anna K. , Chang Martin , Barnard Jennifer , Goldman Bruce I. , Meednu Nida , Rangel-Moreno Javier , Anolik Jennifer H. 
Published: June 2017

Abstract
Neutrophils are well characterized as mediators of peripheral tissue damage in lupus, but it remains unclear whether they influence loss of self-tolerance in the adaptive immune compartment. Lupus neutrophils produce elevated levels of factors known to fuel autoantibody production, including IL-6 and B cell survival factors, but also reactive oxygen intermediates, which can suppress lymphocyte proliferation. To assess whether neutrophils directly influence the progression of autoreactivity in secondary lymphoid organs (SLOs), we characterized the localization and cell–cell contacts of splenic neutrophils at several stages in the progression of disease in the NZB/W murine model of lupus. Neutrophils accumulate in SLO over the course of lupus progression, preferentially localizing near T lymphocytes early in disease and B cells with advanced disease. RNA sequencing reveals that the splenic neutrophil transcriptional program changes significantly over the course of disease, with neutrophil expression of anti-inflammatory mediators peaking during early-stage and midstage disease, and evidence of neutrophil activation with advanced disease. To assess whether neutrophils exert predominantly protective or deleterious effects on loss of B cell self-tolerance in vivo, we depleted neutrophils at different stages of disease. Neutrophil depletion early in lupus resulted in a striking acceleration in the onset of renal disease, SLO germinal center formation, and autoreactive plasma cell production. In contrast, neutrophil depletion with more advanced disease did not alter systemic lupus erythematosus progression. These results demonstrate a surprising temporal and context-dependent role for neutrophils in restraining autoreactive B cell activation in lupus.
A Time for Reflection: Should We Reconsider the Direct Supervision Standard in Clinical Education?
Authors: Mazerolle Stephanie M. , Bowman Thomas G. 
Published: June 2017

Context:Educational reform is occurring again in athletic training. The profession, at this time, should reflect on the structure of clinical education, particularly with direct supervision. Clinical education plays a critical role in the development of future practitioners and should provide students with a chance to gain autonomous experience, with appropriate feedback and discourse.Objective:In this commentary, we discuss direct supervision and present an alternative model for supervision (graduated supervision) in athletic training.Background:Currently, there are concerns regarding the readiness of students to transition to independent practice. These trepidations are centered on the policies related to direct supervision and chances for students to gain autonomous experiences needed to prepare them to make clinical decisions.Synthesis:Graduated supervision may provide an alternative lens for athletic training to regulate clinical education, while facilitating experiences that can assist in student development and preparedness to transition into independent, credentialed patient care.Results:Athletic training supervision policies do not align with other health care professions, yet a major impetus for educational reform was founded on the premise that we should model our degree level more comparably.Recommendation(s):Programs should allow for supervision that encompasses a trusting relationship between preceptors and students. Supervision can be modified (more versus less constant interactions) based upon the students' performance, knowledge, and skills. Shifting the way supervision is implemented can still allow for ensuring patient and student safety, but also allow for students to become critical thinkers.Conclusion(s):Direct supervision policies should be updated to allow students to develop confidence, competence, and critical thinking abilities as well as to better align the athletic training profession with other health care programs.
The Role and Load of the Athletic Training Clinical Education Coordinator
Authors: Radtke Sarah 
Published: June 2017

Context:
The position of clinical education coordinator has been identified as a required one in athletic training education. However, the literature has yet to address the job responsibilities of clinical education coordinators and the commensurate work load/release time needed to accomplish these responsibilities in athletic training education.

Objective:
To determine the current practices of clinical education coordinators in athletic training program, their current load compensation, whether or not they feel their load compensation is appropriate, and what their ideal load compensation should be.

Design:
Mixed methods.

Setting:
Commission on Accreditation of Athletic Training Education–accredited education programs.

Patients or Other Participants:
A total of 120 clinical education coordinators.

Main Outcome Measure(s):
A survey was administered including both quantitative and qualitative questions. Quantitative data were analyzed statistically and qualitative data were analyzed using an inductive approach, revealing themes.

Results:
Statistically significant differences were found when comparing tenure with clinical track in the areas of scholarship and athletic training room coverage. Common job responsibilities for the clinical education coordinator were identified. The study also identified the current and perceived ideal load/release credit for clinical education coordinators based on their program size.

Conclusions:
Clinical education coordinators are incredibly valuable to all athletic training education programs. This study attempted to solidify their value through identifying job responsibilities and load credit criteria to ensure quality clinical education experiences for students.
Professional Master's Athletic Training Programs use Clinical Education to Facilitate Transition to Practice
Authors: Bowman Thomas G. , Mazerolle Stephanie M. , Barrett Jessica L. 
Published: June 2017

Context:Athletic training students' ability to transition into professional practice is a critical component for the future of the profession. However, research on professional master's students' transition to practice and readiness to provide autonomous care is lacking.Objective:To determine professional master's athletic training students' perceptions regarding how they were prepared to transition to practice as clinicians.Design:Qualitative study.Setting:Professional master's athletic training programs.Patients or Other Participants:Sixteen students, 8 program directors, and 5 faculty members from professional master's athletic training programs.Main Outcome Measure(s):An online questionnaire was distributed via Qualtrics and analyzed using an inductive technique. Participants responded to a series of open-ended questions related to the structure and curricular offerings of their respective programs. We secured trustworthiness through multiple analyst triangulation and peer review.Results:We found that both students and faculty identified clinical education as the major facilitator in the socialization process used to prepare students for the transition into clinical practice. Three further subthemes emerged: (1) Both stakeholder groups felt that students gained experience through diverse and immersive clinical education experiences; (2) Preceptors provided mentorship; and (3) Students developed confidence to enter clinical practice as a result of these supported experiences.Conclusions:Professional master's programs provide clinical education experiences designed to help athletic training students gain the skills and confidence necessary to become autonomous practitioners. The diversity and mentorship contained within these experiences facilitates confidence and preparedness.