bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyoderma Vegetans – a Case Report
Authors: Jevremović Ljubica , Ilijin Ivana , Kostić Kristina , Mijušković Željko , Tufegdžić Ivana , Kandolf Sekulović Lidija 
Published: September 2017

AbstractPyoderma vegetans (PV) or blastomycosis-like pyoderma (BLP) is a chronic inflammatory disease, by some authors considered a rare variety of pyoderma gangrenosum (PG), and others describe it as a distinct entity. It commonly presents with verrucous plaques with multiple pustules. The etiology of this disease is unknown, but it has been connected with staphylococcal and streptococcal infections, inflammatory bowel disease, hematological diseases, primary immunodeficiency, alcoholism, and nutritional deficit. Here we present a 66-year-old, otherwise healthy female, with a 2-year-long history of well-defined, vegetative livid plaques with multiple pustules on the dorsal side of both hands. Histopathological analysis of the skin biopsy of the hand showed chronic inflammation and micro-abscesses, ruptured follicular cysts and follicular pseudoepitheliomatous hyperplasia. Treatment with anti-tuberculosis drugs and antibiotics showed to be ineffective, as well as the treatment with systemic corticosteroids, dapsone and cyclosporine. Itraconazole was given for its immunomodulatory effects and findings of Penicillium species in one of the swabs, which led to partial regression of lesions. Since the treatment did not lead to complete resolution, acitretin was indicated 3 months later, but the patient was lost to follow-up.
The Effect of Exchange Rate Movements and Economic Growth on Job Creation
Authors: Chipeta Chama , Meyer Daniel Francois , Muzindutsi Paul-Francois 
Published: September 2017

AbstractJob creation is at the centre of economic development and remains a source of sustenance for social and human relations. The creation of a job-enabling economic environment is imperative in promoting social and economic cohesiveness in the macro and microeconomic environment. Any shocks to the economy, particularly those of exchange rate shocks and changes in economic growth, may negatively affect the labour market and job creation. This study made use of quarterly observations, from the first quarter of 1995 to the fourth quarter of 2015, to investigate the effect of the real exchange rate and economic growth on South Africa’s employment status. South Africa, a developing country, was selected as a case study due to its high unemployment rate that is still increasing. The Vector Autoregressive (VAR) model and multivariate co-integration techniques were used in assessing the impact and responsiveness of employment to the real exchange rate and real economic growth in South Africa. Findings of this study revealed that employment responds positively to economic growth and negatively to the real exchange rate in the long-run. The short-run displays a positive relationship between real economic growth and employment, while the relationship between employment and the real exchange rate is also negative. However, the effect of economic growth in creating jobs is not significant enough in stimulating job creation in South Africa, as indicated by results in variance decomposition. Movements in the exchange rate exerted a significant short and long-run negative effect on employment dynamics; implying that a depreciation of the rand against the U.S. dollar is associated with decrease in overall employment. Exchange rate stability is thus important for economic growth and job creation in South Africa. The study provided further recommendations on promoting job creation in South Africa and other developing countries.
Competitive Condition of Sub-Saharan Africa Commercial Banks
Authors: Akande Joseph Olorunfemi , Kwenda Farai 
Published: September 2017

AbstractThis study assesses the competitive environment and the determinants of the Sub-Saharan Africa commercial banking sectors. We used the Lerner index that is generally acknowledged as the best at estimating the bank level competition and the Generalised Method of Moments (GMM) to study 440 commercial banks for the period 2006 to 2015. We found a monopolistic competitive banking market. We also observed that competition is driven by the level of bank capital including some bank specific variables. Hence, we concluded that the banking market of the SSA region is contestable and competitive. As such, we recommend, among other things, that policy makers should device measures to ensure an ongoing competitive banking environment while stimulating other economic variables to complement this feat.
The Impact of the Problems Faced by Online Customers on Ecommerce
Authors: Sabou Simona , Avram-Pop Bianca , Zima Liliana Adela 
Published: September 2017

Abstract
The purpose of this study is to identify the behavior of customers in the online environment. We analyzed the evolution, characteristics, advantages and disadvantages of this type of commerce, and its implications on the consumers. In order to identify the customers’ behavior online, we selected three variables which are characterized by time intervals of the latest online order, and six variables which analyze the main problems faced by consumers of goods/services bought online (a long shipping time, damaged products, non-compliant products, fraud related issues, underperforming complaint system, technical issues, lack of customer and legal aspects). Online commerce is less developed in the Czech Republic, Romania, Poland, Lithuania, Ireland, Bulgaria, Estonia, Slovenia and Norway. But, the advantages of ecommerce weigh more for the consumer than the problems they face, for example: online shoppers will continue to make online purchases even if they have experienced delays in delivering goods/services, damaged products, online fraud, technical problems or difficulties in finding information about the warranty of goods/services.
Update on Data Reuse in Health Care
Authors: Safran C. 
Published: September 2017

Summary
Objective: Reuse of clinical data has broad use in clinical, research, governmental, and business settings. This summary provides an update on the benefits, barriers to use with large clinical databases, policy frameworks that have been formulated, and challenges.
Methods: This report highlights some recent publications on the diverse uses of clinical data and some policy initiatives to promote reuse. It also contains the opinions of the author.
Results: Although many examples of the benefits of data reuse have been documented, this summary also reviews why the quality of clinical data needs to be the focus of future informatics work.
Conclusion: The promise of reusing data outweighs potential risks, but concerns about privacy and the need to modernize our legal framework will be necessary to realize the full benefits of real-world evidence.
A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine
Authors: Vamathevan J. , Birney E. 
Published: September 2017

Summary
Objectives: To highlight and provide insights into key developments in translational bioinformatics between 2014 and 2016.
Methods: This review describes some of the most influential bioinformatics papers and resources that have been published between 2014 and 2016 as well as the national genome sequencing initiatives that utilize these resources to routinely embed genomic medicine into healthcare. Also discussed are some applications of the secondary use of patient data followed by a comprehensive view of the open challenges and emergent technologies.
Results: Although data generation can be performed routinely, analyses and data integration methods still require active research and standardization to improve streamlining of clinical interpretation. The secondary use of patient data has resulted in the development of novel algorithms and has enabled a refined understanding of cellular and phenotypic mechanisms. New data storage and data sharing approaches are required to enable diverse biomedical communities to contribute to genomic discovery.
Conclusion: The translation of genomics data into actionable knowledge for use in healthcare is transforming the clinical landscape in an unprecedented way. Exciting and innovative models that bridge the gap between clinical and academic research are set to open up the field of translational bioinformatics for rapid growth in a digital era.
Grappling with the Future Use of Big Data for Translational Medicine and Clinical Care
Authors: Murphy S. , Castro V. , Mandl K. 
Published: September 2017

Summary
Objectives: Although patients may have a wealth of imaging, genomic, monitoring, and personal device data, it has yet to be fully integrated into clinical care.
Methods: We identify three reasons for the lack of integration. The first is that “Big Data” is poorly managed by most Electronic Medical Record Systems (EMRS). The data is mostly available on “cloud-native” platforms that are outside the scope of most EMRs, and even checking if such data is available on a patient often must be done outside the EMRS. The second reason is that extracting features from the Big Data that are relevant to healthcare often requires complex machine learning algorithms, such as determining if a genomic variant is protein-altering. The third reason is that applications that present Big Data need to be modified constantly to reflect the current state of knowledge, such as instructing when to order a new set of genomic tests. In some cases, applications need to be updated nightly.
Results: A new architecture for EMRS is evolving which could unite Big Data, machine learning, and clinical care through a microservice-based architecture which can host applications focused on quite specific aspects of clinical care, such as managing cancer immunotherapy.
Conclusion: Informatics innovation, medical research, and clinical care go hand in hand as we look to infuse science-based practice into healthcare. Innovative methods will lead to a new ecosystem of applications (Apps) interacting with healthcare providers to fulfill a promise that is still to be determined.
Clinical Information Systems as the Backbone of a Complex Information Logistics Process: Findings from the Clinical Information Systems Perspective for 2016
Authors: Hackl W. O. , Ganslandt T. 
Published: September 2017

Summary
Objective: To summarize recent research and to propose a selection of best papers published in 2016 in the field of Clinical Information Systems (CIS).
Method: The query used to retrieve the articles for the CIS section of the 2016 edition of the IMIA Yearbook of Medical Informatics was reused. It again aimed at identifying relevant publications in the field of CIS from PubMed and Web of Science and comprised search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms. The retrieved articles were categorized in a multi-pass review carried out by the two section editors. The final selection of candidate papers was then peer-reviewed by Yearbook editors and external reviewers. Based on the review results, the best papers were then chosen at the selection meeting with the IMIA Yearbook editorial board. Text mining, term co-occurrence mapping, and topic modelling techniques were used to get an overview on the content of the retrieved articles.
Results: The query was carried out in mid-January 2017, yielding a consolidated result set of 2,190 articles published in 921 different journals. Out of them, 14 papers were nominated as candidate best papers and three of them were finally selected as the best papers of the CIS field. The content analysis of the articles revealed the broad spectrum of topics covered by CIS research.
Conclusions: The CIS field is multi-dimensional and complex. It is hard to draw a well-defined outline between CIS and other domains or other sections of the IMIA Yearbook. The trends observed in the previous years are progressing. Clinical information systems are more than just sociotechnical systems for data collection, processing, exchange, presentation, and archiving. They are the backbone of a complex, trans-institutional information logistics process.
Findings from the 2017 Yearbook Section on Health Information Management
Authors: Bloomrosen M. , Berner E. S. 
Published: September 2017

Summary
Objectives: To summarize the recent literature and research and present a selection of the best papers published in 2016 in the field of Health Information Management (HIM).
Methods: A systematic review of the literature for the IMIA Yearbook HIM section was performed by the two section editors with the help of a medical librarian. We searched bibliographic databases for HIM-related papers were searched using both MeSH headings and key words in titles and abstracts. A shortlist of candidate best papers was first selected by section editors before being peer-reviewed by independent external reviewers.
Results: The five papers selected as ‘Best Papers’ illustrate a variety of themes, include authors from a variety of countries, and were published in some of the best journals in the field. The themes of the five best papers include health information exchange, personal health records, patient engagement, data quality, and e-quality measures.
Conclusions: The discipline of Health Information Management is increasingly becoming allied with the field of Biomedical Informatics in that both disciplines have interests in common. Traditional HIM areas of expertise (in the pre-electronic health record world), such as coding and privacy and security of health information, are necessary for the electronic exchange and secondary use of health information. With the changes in healthcare delivery brought by the use of electronic health records, addressing issues of information governance is essential. This synopsis discusses these key issues at the intersection of HIM and informatics, examines the potential challenges, and points the way for best practices, future research, and public policy considerations and directions.
Secondary Use of Patient Data: Review of the Literature Published in 2016
Authors: Schlegel D. R. , Ficheur G. 
Published: September 2017

Summary
Objectives: To summarize recent research and emerging trends in the area of secondary use of healthcare data, and to present the best papers published in this field, selected to appear in the 2017 edition of the IMIA Yearbook.
Methods: A literature review of articles published in 2016 and related to secondary use of healthcare data was performed using two bibliographic databases. From this search, 941 papers were identified. The section editors independently reviewed the papers for relevancy and impact, resulting in a consensus list of 14 candidate best papers. External reviewers examined each of the candidate best papers and the final selection was made by the editorial board of the Yearbook.
Results: From the 941 retrieved papers, the selection process resulted in four best papers. These papers discuss data quality concerns, issues in preserving privacy of patients in shared datasets, and methods of decision support when consuming large amounts of raw electronic health record (EHR) data.
Conclusion: In 2016, a significant effort was put into the development of new systems which aim to avoid significant human understanding and pre-processing of healthcare data, though this is still only an emerging area of research. The value of temporal relationships between data received significant study, as did effective information sharing while preserving patient privacy.
Public Health, Population Health, and Epidemiology Informatics: Recent Research and Trends in the United States
Authors: Massoudi B. L. , Chester K. G. 
Published: September 2017

Summary
Objectives: To survey advances in public and population health and epidemiology informatics over the past 18 months. Methods: We conducted a review of English-language research works conducted in the domain of public and population health informatics and published in MEDLINE or Web of Science between January 2015 and June 2016 where information technology or informatics was a primary subject or main component of the study methodology. Selected articles were presented using a thematic analysis based on the 2011 American Medical Informatics Association (AMIA) Public Health Informatics Agenda tracks as a typology.
Results: Results are given within the context developed by Dixon et al., (2015) and key themes from the 2011 AMIA Public Health Informatics Agenda. Advances are presented within a socio-technical infrastructure undergirded by a trained, competent public health workforce, systems development to meet the business needs of the practice field, and research that evaluates whether those needs are adequately met. The ability to support and grow the infrastructure depends on financial sustainability.
Conclusions: The fields of public health and population health informatics continue to grow, with the most notable developments focused on surveillance, workforce development, and linking to or providing clinical services, which encompassed population health informatics advances. Very few advances addressed the need to improve communication, coordination, and consistency with the field of informatics itself, as identified in the AMIA agenda. This will likely result in the persistence of the silos of public health information systems that currently exist. Future research activities need to aim toward a holistic approach of informatics across the enterprise.
Régi és új orális antikoagulánsok hazai alkalmazása pitvarfibrillációban
Authors: Tomcsányi János , Salfer Balázs , Nagy Bence 
Published: September 2017

Abstract: Introduction: Despite a progress in the management of patients with atrial fibrillation this arrhythmia is one of the major causes of stroke, heart failure, sudden death and cardiovascular morbidity. Oral anticoagulation with vitamin K antagonist or non-vitamin K antagonist markedly reduces stroke and mortality in atrial fibrillation patients. Aim: To estimate the real-life vitamin K antagonist and non-vitamin K antagonist oral anticoagulant treatment in past years in Hungary. Method: Analysis of the National Health Insurance Administation database for atrial fibrillation (BNO: I48) between 2010–2015. We assumed that AF patient would turn to health care provides at least once either as inpatients or outpatients in a 5-year period. The patient was accepted as adherent after 6 months therapy and at least 80% oral anticoagulant prescription. Results: The prevalence of AF in Hungary is 3%. The mortality rate of AF 7%–10% per year. The adherence of the old oral anticoagulant treatment was 55%, but it was 69% among patient treated by “new” oral anticoagulant treatment. However, one third of the patients are not treated by effective old or new oral anticoagulant treatment. Conclusions: We need more effort to improve the effective and high adherence oral anticoagulant therapy in our country. Orv Hetil. 2017; 158(39): 1545–1549.
Infantilis haemangioma: klinikai és demográfiai jellemzők, kezelési-gondozási tapasztalatok
Authors: Csoma Zsanett Renáta , Dalmády Szandra , Ábrahám Rita , Rózsa Tamás , Rácz Katalin , Kemény Lajos 
Published: September 2017

Abstract: Introduction: Infantile haemangiomas are the most common vascular tumours of infancy. The vast majority of the lesions do not require dermatological treatment due to their unique clinical course and the high rate of spontaneous regression. Approximately 10–15% of the tumours result in severe complications and sequale, requiring special management and close follow-up. Aim: The aim of the present study was to assess the data of the patients treated with infantile haemangiomas, and to summarize the results of the therapy during 4.5 years of study period, in the Paediatric Dermatology Outpatient Clinic of the Department of Dermatology and Allergology, at the University of Szeged. Method: Demographic data of the infants (gender, gestational age and weight, perinatal history of the infant and medical history of mothers), exact date of the visits at Paediatric Dermatology Outpatient Clinic and tumour characteristics (number, subtype, anatomical localisation and complications) were analysed in details. Treatment modalities and therapy intervals, outcomes and the adverse events of the therapies were also discussed in the survey. Results: During the study period, 96 infants with 163 infantile haemangiomas were observed. 54 patients required regular observations, while 42 infants required local or systemic beta-blocker therapy. All of the tumours treated with local or systemic therapy showed marked clinical regression; adverse effects were observed in only 6 cases. The gestational age and gestational weight of infants requiring beta-blocker therapy was significantly lower as compared to children needed only observation. Conclusions: Systemic propranolol is currently the first-line treatment modality for complicated infantile haemangiomas. Our results confirm the significant therapeutic efficacy of propranolol. Early introduction of the treatment is relevant; unfortunately a great proportion of patients are referred late to Paediatric Dermatology Centres. Orv Hetil. 2017; 158(39): 1535–1544.
EL SABER HISTÓRICO NATURAL. UNA PROPUESTA INSPIRADA EN LA EPISTEMOLOGÍA DE JACQUES MARITAIN
Authors: Carreño P. Juan Eduardo Eduardo , Serani M Alejandro 
Published: September 2017

<p>En este artículo se aporta una clarificación del estatuto que les compete a la paleontología y a otras disciplinas. Tomando como fundamento la epistemología<br />desarrollada por Jacques Maritain, sostenemos que esta clase de indagaciones, por su objeto pretérito y contingente, y por su metodología interpretativa, constituyen un tipo epistemológico específico, diferente del de la ciencia, que aquí catalogamos como histórico-natural.</p>
Dispersão da espécie exótica Achatina fulica a partir de seis focos no Município de Maringá, Paraná
Authors: Eduvirgem Renan Valério , Ferreira Maria Eugênia Moreira Costa 
Published: September 2017

RESUMO O caracol gigante africano é uma espécie exótica que consta na relação das 100 piores espécies invasoras, sendo esta espécie amplamente disseminada pelo território do estado do Paraná, inclusive no município em estudo, Maringá. Os procedimentos metodológicos foram iniciados pela leitura da bibliografia da espécie em estudo, seguida da obtenção de dados na Secretária de Saúde de Maringá com propósito de conhecer a trajetória da espécie Achatina fulica em Maringá. Com base nos dados levantados e nas entrevistas com os moradores nas zonas urbana e rural do Município, foi possível caracterizar a trajetória. A etapa seguinte consistiu na utilização do software Quantum GIS 2.18.1 De acordo com a literatura a respeito da espécie, o caracol gigante africano em estágio jovem se locomove 500 metros a cada 6 meses, ou seja, 1 Km a cada ano. Neste estudo conseguimos projetar o tempo aproximado da dispersão do caracol gigante africano em praticamente todo o Município de Maringá, na qual o tempo estimado foi de aproximadamente 10 anos com a projeção de seis focos de dispersão, assim, comprovando o elevado potencial de dispersão desta espécie exótica. PALAVRAS-CHAVE: Caracol gigante africano. Espacialização. Geotecnologia.