bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Ta/W Mixed Addenda Heteropolyacid with Excellent Acid Catalytic Activity and Proton‐Conducting Property.
Authors: Li Shunjun , Peng Qingpo , Chen Xuenian , Wang Ruoya , Zhai Jianxin , Hu Weihua , Ma Fengji , Zhang Jie , Liu Shuxia 
Published: October 2016

AbstractYellow crystals of H20 [P8W60Ta12(H2O)4 (OH)8O236]·125H2O are obtained from an aqueous solution of K8Na8H4 [P8W60Ta12(H2O)4 (OH)8O236]·42H2O by ion exchange (HCl‐loaded Amberlite IR120B, 95% yield) followed by recrystallization in water (91% yield).
ChemInform Abstract: Express and Low‐Cost Microwave Synthesis of the Ternary Chevrel Phase Cu2Mo6S8 for Application in Rechargeable Magnesium Batteries.
Authors: Murgia Fabrizio , Antitomaso Philippe , Stievano Lorenzo , Monconduit Laure , Berthelot Romain 
Published: October 2016

AbstractCu2Mo6S8 is prepared by solid state microwave‐assisted reaction of MoS2, Mo, and Cu in stoichiometric quantities using a graphitized quartz tube in a carbon powder filled Al2O3 crucible covered by mineral wool (1200 W, 400 s) followed by rapid cooling in H2O.
ChemInform Abstract: A Synthesis of Benzothiazoles and Indoles by Direct C(sp2)—I Activation Catalyzed by Copper(II) on Silica‐Coated Magnetite Nanoparticles.
Authors: Moghadam Faeze Kiani , Jarrah Najmeh , Mashayekh‐Salehi Ali , Ghanbaripour Rashid 
Published: October 2016

AbstractThe catalyst is recyclable and reusable at least four times without any significant loss in yield.
ChemInform Abstract: Synthesis of β‐Cyano Ketones Promoted by a Heterogeneous Fluoride Catalyst.
Authors: Strappaveccia Giacomo , Angelini Tommaso , Bianchi Luca , Santoro Stefano , Piermatti Oriana , Lanari Daniela , Vaccaro Luigi 
Published: October 2016

AbstractThe protocol uses Amberlite IRA 900 F as the catalyst and allows the isolation of pure β‐cyanoketones without any purification except in the case of (VIIb) and (IXa).
ChemInform Abstract: Palladium‐Catalyzed C(sp2)‐H Bond Alkylation of Ketoximes by Using the Ring‐Opening of Epoxides.
Authors: Li Dan‐Dan , Niu Liang‐Feng , Ju Zhi‐Yu , Xu Zhihong , Wu Changzeng 
Published: October 2016

AbstractReaction proceeds well with O‐methyl ketoximes giving regioselectively ortho‐alkylated products (at the least hindered position) in good yields.
ChemInform Abstract: Lewis Acid‐Catalyzed [3 + 2] Cycloaddition of Donor‐Acceptor Cyclopropanes and Enamines: Enantioselective Synthesis of Nitrogen‐Functionalized Cyclopentane Derivatives.
Authors: Verma Kamal , Banerjee Prabal 
Published: October 2016

AbstractReaction of the title substrates in the presence of MgI2 or Cu(O‐Tf)2 leads to an efficient preparation of various highly functionalized cyclopentanes, generally with good to excellent diastereoselectivity.
ChemInform Abstract: Cross‐Coupling of Vinylethylene Carbonates with Arylboronic Acids Catalyzed by in situ Generated Palladium Nanoparticles in Water.
Authors: Mao Yuxue , Zhai Xing , Khan Ajmal , Cheng Jiong , Wu Xue , Zhang Yong Jian 
Published: October 2016

AbstractIt is found that Pd(OAc)2 is reduced to form Pd‐nanoparticles by homo‐coupling of phenylboronic acid.
ChemInform Abstract: Rhodium‐Catalyzed Alkene Difunctionalization with Nitrenes.
Authors: Ciesielski Jennifer , Dequirez Geoffroy , Retailleau Pascal , Gandon Vincent , Dauban Philippe 
Published: October 2016

AbstractA broad spectrum of 1,2‐amino alcohols and 1,2‐diamines is synthesized as is demonstrated for a series of selected examples.
ChemInform Abstract: Asymmetric Cross‐Coupling of Racemic α‐Bromo Esters with Aryl Grignard Reagents Catalyzed by Cyclopropane‐Based Bisoxazolines Cobalt Complexes.
Authors: Liu Feipeng , Bian Qinghua , Mao Jianyou , Gao Zidong , Liu Dan , Liu Shikuo , Wang Xueyang , Wang Yu , Wang Min , Zhong Jiangchun 
Published: October 2016

AbstractAmong 4 ligands synthesized, Cyp‐BOX is found to be the optimal one.
ChemInform Abstract: Organocatalytic Asymmetric Michael Addition of α‐Alkylidene Succinimides to Nitrostyrenes.
Authors: Zhao Bo‐Liang , Zhang Dongxiang , Liu Lei , Du Da‐Ming 
Published: October 2016

AbstractA squaramide‐catalyzed enantioselective conjugate addition reaction of alkylidenesuccinimides with β‐nitrostyrenes and a nitro diene gives the corresponding alkylidene(3‐nitropropyl)succinimides in good to excellent yields with high to excellent diastereoselectivities and enantioselectivities.
ChemInform Abstract: Efficient Synthesis of 3‐Substituted Indoles via a Base‐Free Copper‐Catalyzed Three‐Component Reaction in Water.
Authors: Jiang Haojie , Wang Leilei , Xie Jianwei 
Published: October 2016

AbstractThe title indoles are prepared under environmentally friendly conditions via reaction of indoles, aldehydes, and malononitrile in good to excellent yields.
ChemInform Abstract: Rhodium(II)‐catalyzed Direct Sulfenylation of Diazooxindoles with Disulfides.
Authors: Khanal Hari Datta , Kim Sung Hong , Lee Yong Rok 
Published: October 2016

AbstractThe title process provides a rapid route to 3‐alkylthiooxindoles and 3,3‐diarylthiooxindoles.
ChemInform Abstract: Synthesis of Trifluoromethylated Isoxazoles and Their Elaboration Through Inter‐ and Intra‐Molecular C—H Arylation.
Authors: Poh Jian‐Siang , Garcia‐Ruiz Cristina , Zuniga Andrea , Meroni Francesca , Blakemore David C. , Browne Duncan L. , Ley Steven V. 
Published: October 2016

AbstractConditions for the cycloaddition of a broad range of aryl or alkyl alkynes onto in‐situ‐prepared trifluoromethylnitrile oxide are elaborated providing diverse trifluoromethylated isoxazole building blocks.
ChemInform Abstract: Tao‐Phos‐Controlled Desymmetrization of Succinimide‐Based Bisalkynes via Asymmetric Copper‐Catalyzed Huisgen Alkyne—Azide Click Cycloaddition: Substrate Scope and Mechanism.
Authors: Chen Mu‐Yi , Song Tao , Zheng Zhan‐Jiang , Xu Zheng , Cui Yu‐Ming , Xu Li‐Wen 
Published: October 2016

AbstractThe enantioselective 1,3‐dipolar azide cycloaddition affords triazoles with moderate to high enantioselectivity.
ChemInform Abstract: A Tunable Route to Oxidative and Eliminative [3 + 2] Cycloadditions of Organic Azides with Nitroolefins: CuO Nanoparticles Catalyzed Synthesis of 1,2,3‐Triazoles under Solvent‐Free Condition.
Authors: Gangaprasad D. , Raj J. Paul , Kiranmye T. , Sasikala R. , Karthikeyan K. , Rani S. Kutti , Elangovan J. 
Published: October 2016

AbstractIn the presence of the CuO nanoparticles catalyst under solvent‐free condition, the nitro group is retained in the product while it gets eliminated in the absence of the catalyst.
ChemInform Abstract: Selective Synthesis of δ‐Lactone via Palladium Nanoparticles‐Catalyzed Telomerization of CO2 with 1,3‐Butadiene.
Authors: Song Jiliang , Feng Xiujuan , Yamamoto Yoshinori , Almansour Abdulrahman I. , Arumugam Natarajan , Kumar Raju Suresh , Bao Ming 
Published: October 2016

AbstractThe Pd‐nanoparticles are generated in situ using Pd(OAc)2 as the precatalyst in the presence of tetrabutylammonium acetate as both reducing and stabilizing agent in MeCN.
ChemInform Abstract: Application of the 2(5H)Furanone Motif in the Synthesis of New Thiopyrano[2,3‐d]thiazoles via the Hetero‐Diels—Alder Reaction and Related Tandem Processes.
Authors: Lozynskyi Andrii , Zimenkovsky Borys , Karkhut Andriy , Polovkovych Svyatoslav , Gzella Andrzej K. , Lesyk Roman 
Published: October 2016

AbstractThe hetero‐Diels—Alder reaction of rhodanines with furanones is examined to yield linearly condensed heterocycles.
ChemInform Abstract: Synthesis and Reactivity of Triazaphenanthrenes.
Authors: Fernandez Sarah , Ganiek Maximilian A. , Karpacheva Mariia , Hanusch Fabian C. , Reuter Stephan , Bein Thomas , Auras Florian , Knochel Paul 
Published: October 2016

AbstractA four‐step synthesis of triazaphenanthrenes and chlorinated derivatives thereof is described.
ChemInform Abstract: One‐Pot Three‐Component Synthesis of Quinazolines via a Copper‐Catalyzed Oxidative Amination Reaction.
Authors: Duan Tiantian , Zhai Tianran , Liu Huanhuan , Yan Zilong , Zhao Yue , Feng Lei , Ma Chen 
Published: October 2016

AbstractThe title reaction between various 2‐aminophenyl derivatives, dimethylsulfoxide and ammonium acetate efficiently provides quinazolines.
ChemInform Abstract: Synthesis of Dihydroquinoxaline‐2(1H)‐ones via Palladium‐Catalyzed Intramolecular C—N Bond Formation.
Authors: Areephong Jetsuda , Huo Bright , Mbaezue Ifenna I. , Ylijoki Kai E. O. 
Published: October 2016

AbstractThe cyclization reaction does not display significant substitution dependence, proceeding well for both alkyl and aryl substituted substrates.
ChemInform Abstract: One‐Pot Synthesis of 5‐Hydroxy‐4H‐1,3‐thiazin‐4‐ones: Structure Revision, Synthesis, and NMR Shift Dependence of Thiasporine A.
Authors: Seitz Tobias , Fu Peng , Haut Franz‐Lucas , Adam Lutz , Habicht Marija , Lentz Dieter , MacMillan John B. , Christmann Mathias 
Published: October 2016

AbstractThe annulation of arylthioamides, which may be applied to alkylthioamides, with 3‐bromopyruvic acid chloride is investigated offering access to the proposed structure of thiasporine A [cf.
ChemInform Abstract: A Novel C22 Terpenoid from the Cultured Perovskia atriplicifolia.
Authors: Jiang Zhi‐Yong , Zhu Le‐Yu , Zhou Jun , Hu Qiu‐Fen , Yang Guang‐Yu , Huang Xiang‐Zhong , Liu Wen‐Xing , Gao Lu , Li Gan‐Peng , Xia Fu‐Ting 
Published: October 2016

AbstractThe title compound (I), called perovskiaol, exhibits significant cytotoxic activity inhibiting NB4, A549 as well as HepG2 cells.
ChemInform Abstract: Two New Triterpenoid Glycosides from the Roots of Rosa cymosa Tratt
Authors: Ma Guo‐Xu , Huang Xiao‐Yan , Dai Hua‐Nian , Zhong Xiao‐Qing , Zhou Yan‐Lin , Su Zuo‐Lin , He Ying‐Zi , Yang Jun‐Shan , Yuan Jing‐Quan , Xu Xu‐Dong 
Published: October 2016

Abstractisolation, structure elucidation and inhibitory activity against LPS‐induced NO production in macrophages
ChemInform Abstract: Silver Trifluoromethanesulfonate and Metallic Copper Mediated Syntheses of 1,2,3‐Triazole‐O‐ and Triazolyl Glycoconjugates: Consecutive Glycosylation and Cyclization under One‐Pot Condition.
Authors: Dutta Samrat , Gupta Shyam Ji , Sen Asish Kumar 
Published: October 2016

AbstractThe title reaction involves consecutive glycosidation and azide alkyne cyclization under one‐pot conditions using a combination of AgOTf and Cu(0) catalyst.
Prasugrel Use Following PCI and Associated Patient Outcomes: Insights From the National VA CART Program
Authors: Aggarwal Vikas , Armstrong Ehrin J. , Liu Wenhui , Maddox Thomas M. , Ho P. Michael , Carey Evan , Wang Tracy , Sherwood Matthew , Tsai Thomas T. , Rumsfeld John S. , Bradley Steven M. 
Published: October 2016

ABSTRACTBackgroundPrasugrel is more effective than clopidogrel in preventing thrombotic complications after percutaneous coronary intervention (PCI) among patients with acute coronary syndromes (ACS), but it increases the risk of bleeding in subgroups of patients. There is limited data on whether prasugrel use in routine practice is targeted to clinical settings with greatest anticipated patient benefit.MethodsIn a national cohort of 11 617 veterans who underwent PCI between 2010 and 2013 at Veterans Administration hospitals nationwide, we assessed overall trends in the use of prasugrel and the frequency of prasugrel use in patients with contraindications (prior transient ischemic attack or cerebrovascular accident), higher bleeding risk (age ≥75 or weight <60 kg), and nonindicated settings (non–acute coronary syndrome [non‐ACS]). We then evaluated the association between prasugrel use and 1‐year risk‐adjusted mortality, myocardial infarction, and major bleeding rates.ResultsOverall, 1040 (9.0%) patients who received prasugrel after PCI were included. Prasugrel was infrequently used in contraindicated (2.4%) or higher‐bleeding‐risk (1.8%) settings. Additionally, 35.8% of patients received prasugrel in settings that lack evidence of clinical benefit (ie, non‐ACS). Compared with clopidogrel, there were no significant differences in risk‐adjusted mortality, myocardial infarction, or major bleeding outcomes with prasugrel therapy at 1‐year follow‐up.ConclusionsPrasugrel use after PCI in the Veterans Administration is low and prasugrel was rarely used in contraindicated or high‐bleeding‐risk settings. However, a third of patients received prasugrel for off‐label non‐ACS indications that lack efficacy data.
Targeting Cancer Cells with a Bisphosphonate Prodrug
Authors: Matsumoto Kenji , Hayashi Kosuke , Murata‐Hirai Kaoru , Iwasaki Masashi , Okamura Haruki , Minato Nagahiro , Morita Craig T. , Tanaka Yoshimasa 
Published: October 2016

AbstractNitrogen‐containing bisphosphonates have antitumor activity in certain breast cancer and myeloma patients. However, these drugs have limited oral absorption, tumor cell entry and activity, and cause bone side effects. The potencies of phosphorylated antiviral drugs have been increased by administering them as prodrugs, in which the negative charges on the phosphate moieties are masked to make them lipophilic. We synthesized heterocyclic bisphosphonate (BP) prodrugs in which the phosphonate moieties are derivatized with pivaloyloxymethyl (pivoxil) groups and that lack the hydroxy “bone hook” on the geminal carbon. When the lipophilic BP prodrugs enter tumor cells, they are converted into their active forms by intracellular esterases. The most active BP prodrug, tetrakispivaloyloxymethyl 2‐(thiazole‐2‐ylamino)ethylidene‐1,1‐bisphosphonate (7), was found to potently inhibit the in vitro growth of a variety of tumor cell lines, especially hematopoietic cells, at nanomolar concentrations. Consistent with this fact, compound 7 inhibited the prenylation of the RAP1A small GTPase signaling protein at concentrations as low as 1–10 nm. In preclinical studies, 7 slowed the growth of human bladder cancer cells in an immunodeficient mouse model. Thus, 7 is significantly more active than zoledronic acid, the most active FDA‐approved BP, and a potential anticancer therapeutic.
Oxygen Consumption is Limited at an Ecologically Relevant Rearing Temperature in Pupfish Eggs
Authors: Jones Alexander C. , Lim David , Wayne‐Thompson Jacoby J. , Urbina Natasha , Puentedura Georgina , Hillyard Stanley , Breukelen Frank Van 
Published: October 2016

ABSTRACTThe habitat of the critically endangered Devils Hole Pupfish, Cyprinodon diabolis is marked by constant high temperatures and low oxygen availability. In order to explore the effects of these conditions on development and recruitment of eggs in Devils Hole, we tested the effects of two ecologically relevant temperatures on the development, hatch success, and oxygen consumption of eggs from a refuge population of pupfish derived from C. diabolis and eggs from its close sister species, Cyprinodon nevadensis mionectes. We developed a simple method to measure oxygen consumption in a single egg. Parent acclimation temperature, rather than incubation temperature, was the most important factor influencing hatch success. Eggs incubated at 33°C hatched more quickly compared to those incubated at 28°C. Despite this accelerated development, larvae from both temperatures were of similar size at hatch. Unexpectedly, eggs incubated at 33°C experience lower than expected oxygen consumption rates compared to those incubated at 28°C. Oxygen consumption rates would be limited at PO2 values that are much higher than environmental oxygen tensions. Oxygen consumption increased dramatically upon hatch, indicating that low oxygen conditions such as those present in Devils Hole may limit developing eggs.
Optical dating of loessic hillslope sediments constrains timing of prehistoric rockfalls, Christchurch, New Zealand
Authors: Sohbati Reza , Borella Josh , Murray Andrew , Quigley Mark , Buylaert Jan‐Pieter 
Published: October 2016

ABSTRACTDeveloping a robust chronology for mass‐movement events is of crucial importance to understanding triggering mechanisms and assessing hazards. We constrain the emplacement time of four palaeorockfall boulders near Christchurch, New Zealand, using optically stimulated luminescence (OSL) of quartz and infrared stimulated luminescence dating (IRSL) of K‐feldspar from loessic hillslope deposits underlying and upslope of individual boulders. The quartz OSL and K‐feldspar pIRIR290ages are all consistent with the stratigraphy and in excellent agreement with each other, indicating that all the boulders that overlie thein situloess must have been emplaced <13 ka ago. A comparison of luminescence ages with cosmogenic3He surface‐exposure ages from the surfaces of each boulder shows that two out of four boulders contain pre‐deposition3He inheritance. Overall, the optical ages are consistent with both a prehistoric rockfall event at 6–8 ka and a possible preceding event at 12–14 ka. This study is the first to show a successful application of luminescence dating to New Zealand colluvium loess and demonstrates the great advantage of a multi‐technique approach in mass‐movement dating.
Flow‐pattern evolution of the Laurentide and Cordilleran ice sheets across west‐central Alberta, Canada: implications for ice sheet growth, retreat and dynamics during the last glacial cycle
Authors: Atkinson Nigel , Pawley Steven , Utting Daniel J. 
Published: October 2016

ABSTRACTThis paper presents a reconstruction of the geometry, dynamics and flow pattern of the Laurentide and Cordilleran ice sheets along the Albertan portion of the eastern Canadian Rocky Mountains during the last glaciation. Sediment–landform associations relating to the evolution of these ice sheets document their initial convergence and mutual deflection across west‐central Alberta. The continued advance of Laurentide ice locally displaced Cordilleran ice westward into the Front Ranges, and deflected trunk ice emerging from the Athabasca River valley south‐eastwards along the Foothills. These convergent flow patterns remained major features in the regional geometry of both ice sheets throughout the Last Glacial Maximum. The onset of deglaciation was characterized by the northward retreat of the Laurentide Ice Sheet, which progressively unblocked valleys along the mountain front. The configuration of buttress removal initiated the Lateglacial expansion and sequential drawdown of the eastern Cordilleran Ice Sheet along fast‐flowing outlet glaciers. Subsequent regional retreat of Laurentide and Cordilleran ice was associated with the development of large proglacial lakes which amplified deglaciation by destabilizing the margins of both ice sheets, triggering extensive readvances due to periodic changes in water level associated with the opening and closing of outlets by ice margin fluctuations.
Dental mesowear reflects local vegetation and niche separation in Pleistocene proboscideans from Britain
Authors: Saarinen Juha , Lister Adrian M. 
Published: October 2016

ABSTRACTProboscideans, and elephants in particular, played a key role in Pleistocene mammal communities in Europe. The British Pleistocene fossil record provides a unique opportunity to study changes in proboscidean feeding ecology associated with environmental proxy data such as pollen records and the presence of competitors. Here we utilize a recently introduced dietary analysis method, mesowear angle analysis, for studying relationships between dietary variation in proboscideans, changes in available vegetation and the presence of sympatric proboscidean species. The method is based on recording the relief of worn molar surfaces as angle measurements, which reflect attrition‐ vs. abrasion‐dominated feeding and serve as a proxy for grazing vs. browsing diets. By comparison with pollen records, we show that blunt mesowear angles specifically reflect grass eating rather than open‐ground feeding in general. We further find that all British Pleistocene proboscidean species were relatively flexible feeders able to shift their dietary preference according to local vegetation composition. Nonetheless, when more than one proboscidean species occurred in the same environment, they always show significantly different mean mesowear signal, suggesting dietary niche separation.
Assessment of Long‐Term Soil Erosion in a Mountain Vineyard, Aosta Valley (NW Italy)
Authors: Biddoccu Marcella , Zecca Odoardo , Audisio Chiara , Godone Franco , Barmaz Andrea , Cavallo Eugenio 
Published: October 2016

AbstractIn the mountain region of Aosta Valley, NW Italy, grapevine were, in the past, traditionally grown on terraces supported by dry stone walls. Since the 1960s, terrace systems were gradually abandoned in favour of an up and down slope row orientation. Tillage and chemical weeding are common soil management techniques adopted in vineyards with high slope gradient, to maintain bare soil. Both techniques expose, to varying degrees, the soil to degradation, favouring runoff and soil losses. Although many studies have focused on the effects of soil water erosion in vineyards, there is still a gap in the evaluation of long‐term soil erosion rates in vineyards located on very steep slopes (higher than 35%). In order to evaluate long‐term soil erosion on a very steep vineyard, a study was carried out on a 44‐year‐old vineyard located at about 900 m asl. The vine rows were oriented up and down the slope, which is about 50% (29°). The inter‐row soil management of the vineyard included chemical weeding and, in the first year after plantation, the adoption of irrigation and hilling‐up/taking‐out the soil around the vines. The soil loss was determined adopting the technique of botanical benchmark. According to this methodology, the estimated total soil lost over 44 years was about 692 Mg ha−1, with average annual soil loss of 15·7 Mg ha−1 year−1, confirming that the water and management practices adopted in the vineyard, besides the high slope gradient, have played a relevant role in determining the high erosion rate. Copyright © 2016 John Wiley & Sons, Ltd.
Physical Properties and Stability of Soft Gelled Chitosan‐Based Nanoparticles
Authors: Goycoolea Francisco M. , Brunel Fabrice , Gueddari Nour E. El , Coggiola Anna , Lollo Giovanna , Moerschbacher Bruno M. , Remuñán‐López Carmen , Delair Thierry , Domard Alain , Alonso María J. 
Published: October 2016

We addressed the role of the degree of acetylation (DA) and of Mw of chitosan (CS) on the physical characteristics and stability of soft nanoparticles obtained through either ionic cross‐linking with sodium tripolyphosphate (TPP), or reverse emulsion/gelation. Each of these methods affords nanoparticles (NPs) or nanogels (NGs), respectively. The size of CS–TPP NPs comprising CS of high Mw (≈123–266 kDa) increases with DA (≈1.6%–56%), while it do not change for CS of low Mw (≈11–13 kDa); the zeta potential (ζ) decreases with DA regardless of Mw (ζ ≈+34.6 ± 2.6 to ≈+25.2 + 0.6 mV) and the NPs appear as spheres in transmission electron microscopy. Stability in various cell culture media (pH 7.4 at 37 °C) is greater for NPs made with CS of DA ≥ 27%. In turn, NGs exhibit larger sizes (520 ± 32 to 682 ± 27 nm) than do CS–TPP NPs, and can only be formed with CS of DA < 30%. The average diameter size for these NGs shows a monotonic increase with CS's Mw. The physical properties and stability of these systems in biological media depend mostly on the DA of CS and its influence on the balance between hydrophilic/hydrophobic interactions.
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