bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Triassic capitosaurian remains from Svalbard and the palaeobiogeographical context of Scandinavian Arctic temnospondyls
Authors: Kear Benjamin P. , Poropat Stephen F. , Bazzi Mohamad 
Published: December 2015

Abstract

The Norwegian Arctic Svalbard archipelago is famous for its prolific record of Early–Middle Triassic vertebrate fossils. These represent mainly marine amniotes, together with sharks, bony fishes and temnospondyl amphibians, the latter providing an important faunal correlate with coeval assemblages from the Danish autonomous region of Greenland. However, substantial biostratigraphical gaps exist in the Upper Triassic strata of Svalbard, which are marked by pronounced facies shifts from marine to deltaic systems and intermittent depositional hiatuses. These are accompanied by a dearth of documented vertebrate remains, a notable exception being the partial skull of the capitosaurian
Capitosaurus polaris
and a few isolated stereospondylian intercentra probably from the middle–late Carnian De Geerdalen Formation of Spitsbergen. Reassessment of this material, which incorporates the only undisputed capitosaurian fossil from Svalbard, indicates affinity with
Cyclotosaurus
, known elsewhere from the late Norian–early Rhaetian Fleming Fjord Formation of Greenland. The Scandinavian Arctic temnospondyls constituted components of sympatric assemblages that inhabited the Boreal margin of Pangaea throughout the Triassic.
Coprolites from the Late Triassic Kap Stewart Formation, Jameson Land, East Greenland: morphology, classification and prey inclusions
Authors: Hansen Bitten Bolvig , Milàn Jesper , Clemmensen Lars B. , Adolfssen Jan Schulz , Estrup Eliza Jarl , Klein Nicole , Mateus Octávio , Wings Oliver 
Published: December 2015

Abstract
A large collection of vertebrate coprolites from black lacustrine shales in the Late Triassic (Rhaetian–Sinemurian) Kap Stewart Formation, East Greenland is examined with regard to internal and external morphology, prey inclusions, and possible relationships to the contemporary vertebrate fauna. A number of the coprolites were mineralogically examined by X-ray diffraction (XRD), showing the primary mineral composition to be apatite, clay minerals, carbonates and, occasionally, quartz in the form of secondary mineral grains. The coprolite assemblage shows multiple sizes and morphotypes of coprolites, and different types of prey inclusions, demonstrating that the coprolite assemblage originates from a variety of different producers.

Supplementary material:

A description of the size, shape, structure, texture, contents and preservation of the 328 specimens is available at
https://doi.org/10.6084/m9.figshare.c.2134335
Reservoir architectures of interlava systems: a 3D photogrammetrical study of Eocene cliff sections, Faroe Islands
Authors: Vosgerau Henrik , Passey Simon R. , Svennevig Kristian , Strunck Max N. , Jolley David W. 
Published: December 2015

Abstract

Following the intra-volcanic Rosebank discovery in the Faroe–Shetland Basin, NE Atlantic, there has been a need to find suitable analogues to characterize reservoir architectures, connectivities and compartmentalization of interlava clastic beds. The Faroe Islands, situated
c.
160–190 km to the NW of this discovery, are an exposed remnant of the Palaeogene lava field host and the near-vertical cliff sections afford the opportunity to map lateral variations over many kilometres. This was achieved through 3D photogrammetry based on high-resolution digital photographs taken from a helicopter. The study focused on the Eocene Enni Formation, which is dominated by a mixture of simple and compound lava flows commonly separated by minor volcaniclastic beds, including the widespread Argir Beds. In general, the interlava beds are tabular shaped and <1 to
c.
6 m thick. Locally they thicken in depressions formed by the wedging out or differential erosion of underlying lava flow lobes. Connectivity may be caused by the wedging out of successive lava flows leading to the lateral merging of interlava beds or more rarely be hydraulically connected via conglomeratic fills of major channels. Lateral compartmentalization may be caused by the intersection of interlava beds by dykes, lava tubes, lava-filled channels or reverse faults.
Abstract A28: C-reactive protein as a predictive marker of response to sunitinib treatment in metastatic clear cell renal carcinoma
Authors: Pilskog Martin , Beisland Christian , Straume Oddbjørn 
Published: December 2015

Abstract
Background: Antiangiogenic treatment, is currently first line therapy in metastatic renal cell carcinoma (RCC). Due to high drug costs and potentially serious side effects there is an urgent need for clinically useful predictive markers. We conducted a single center phase II clinical trial with sunitinib treatment for metastatic RCC.
Study Design: Forty-five patients with metastatic or non-resectable clear cell RCC were included. Sunitinib was given in cycles of six weeks (four weeks of treatment, two weeks pause). Follow up was every six week. Primary endpoint was response rates (RECIST 1.1). Secondary endpoints were time to progression (TTP) and overall survival (OS). Toxicity and quality of life were recorded.
Results: Twenty five (55 %) cases showed clinical benefit with complete response (CR): 1, partial response (PR): 6, stable disease (SD)&gt;6months: 18. Twelve patients showed progressive disease (PD). Eight patients stopped treatment or were still under treatment prior to the first radiologic evaluation, and were recorded as non-evaluable. The following parameters were recorded at baseline; gender, age, ECOG-, WHO- and Karnofsky's performance status, Heng- and Motzer prognostic criteria, blood pressure, hemoglobin, white blood count, neutrophil count, platelets, sodium, potassium, creatinine, corrected calcium, C-reactive protein(CRP), albumin, lactate dehydrogenase, thyroid-stimulating hormone, thyroid hormones and D dimer, body mass index, use of antihypertensive medication, location of metastasis and tumor load. Of these, CRP ≤ 10 mg/L at baseline (vs CRP &gt; 10 mg/L), was significantly associated with objective response (CR+PR) (Fisher's Exact test, p=0,030). Good performance status showed a significant association with clinical benefit (Fisher's Exact test, p=0,049). Toxicity data and quality of life data will be presented.
Conclusion: Of the clinical markers under investigation, only CRP at baseline as well as performance status were found to be possible predictive markers of response to sunitinib in metastatic RCC. Our patient population is comparable to those in already reported studies and might be useful to further investigations of angiogenesis related predictive markers of response.
Citation Format: Martin Pilskog, Christian Beisland, Oddbjørn Straume. C-reactive protein as a predictive marker of response to sunitinib treatment in metastatic clear cell renal carcinoma. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers; Mar 5-8, 2015; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl):Abstract nr A28.
Abstract B13: Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment
Authors: McDonald Lindsay T. , Laws Dayvia A. , Kelly Ryan R. , Xiong Ying , Motamarry Anjan , Patel Risha K. , Jones Jeffrey A. , Watson Patricia M. , Turner David P. , Watson Dennis K. , Soloff Adam C. , Findlay Victoria J. , LaRue Amanda C. 
Published: December 2015

Abstract
Targeting the tumor microenvironment is critical towards improving the effectiveness of current cancer therapeutics. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types of the tumor microenvironment, playing an important role in tumor progression and angiogenesis. Multiple origins for CAFs have been proposed including resident fibroblasts, adipocytes, and bone marrow. Our laboratory previously identified a novel hematopoietic stem cell (HSC) origin for CAFs; however, the functional roles of HSC-derived CAFs (HSC-CAFs) in tumor progression have not yet been examined. Thus, to test the hypothesis that HSC-CAFs promote tumor progression via contribution to extracellular matrix (ECM) and through paracrine production of pro-angiogenic factors, we developed a method to isolate HSC-CAFs. HSC-CAFs were profiled based on their expression of hematopoietic and fibroblastic markers in two murine tumor models, Lewis lung carcinoma (LLC) and E0771 breast cancer. Findings revealed HSC-CAF production of factors associated with both ECM deposition and remodeling. Functional in vivo studies showed that co-injection of HSC-CAFs with tumor cells resulted in increased tumor growth rate and significantly larger tumors than injection of tumor cells alone. Immunohistochemical studies revealed increased blood vessel density with co-injection, demonstrating a role for HSC-CAFs in tumor progression through promotion of tumor vascularization in vivo. Mechanistic in vitro studies indicated a role for HSC-CAF produced vascular endothelial growth factor (VEGF-A) and transforming growth factor-beta-1 (TGFβ-1) in endothelial tube formation and vascular patterning. These in vitro and in vivo findings suggest that HSC-CAFs are a critical component of the tumor microenvironment contributing to ECM production, ECM remodeling, and tumor vascularization. Given their role in multiple components of tumor progression, targeting the novel HSC-CAF may be a promising therapeutic strategy alone or in combination with existing anti-angiogenesis therapies.
Citation Format: Lindsay T. McDonald, Dayvia A. Laws, Ryan R. Kelly, Ying Xiong, Anjan Motamarry, Risha K. Patel, Jeffrey A. Jones, Patricia M. Watson, David P. Turner, Dennis K. Watson, Adam C. Soloff, Victoria J. Findlay, Amanda C. LaRue. Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers; Mar 5-8, 2015; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl):Abstract nr B13.
Abstract B20: Activin receptor-like kinase 1 complexes with endoglin in TGFß-mediated signaling in angiogenesis
Authors: Hawker James , Varacallo Patricia , Duffy Iain 
Published: December 2015

Abstract
Background: Activin Receptor-Like Kinase 1 (ALK1), a type I transforming growth factor (TGFß) family receptor, and endoglin, a type III receptor, are expressed in endothelial cells (EC) and involved in angiogenesis. Control of angiogenesis is critical in diseases such as cancer. Four ligands, TGFß, activin, bone morphogenetic protein 9 (BMP-9), and BMP-10, have been shown to bind ALK-1. Thus angiogenesis may be mediated by different combinations of ligands and receptors. Purpose: We investigated the role of TGFß and ALK-1 in tube formation. We also screened EC and also cancer cell lines for expression of various TGFß family receptors to begin to address which ligands and receptors are involved in angiogenesis and endothelial-tumor interactions,. Results: We also show that fibroblast growth factor 2 (FGF-2) + TGFß increase ALK-1 but not ALK 5 type I receptor expression in endothelial cells after tube formation. We show data that the type I receptor Activin-Like Kinase 1 and the co-receptor endoglin can signal in endothelial cells via the TGFß ligand. Antisense RNA that targets ALK 1 (and also ALK5) also disrupts tube formation. We further show that endogenous activin binds ALK 1 and can be displaced by exogenous TGFß. This suggests it may function to regulate control of ALK 1 activation. Further, ALK-1 and endoglin may also be involved in cell-cell interactions between endothelial and other cells. Thus we screened endothelial and cancer cells for TGFß family receptor expression by RT-PCR. Endothelial cells show similar expression of ALK-1, ALK-5, and endoglin and lower expression of BMP receptor II and TGFßRII. Cancer cells show much lower expression of type II receptors.
Citation Format: James Hawker, Patricia Varacallo, Iain Duffy. Activin receptor-like kinase 1 complexes with endoglin in TGFß-mediated signaling in angiogenesis. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers; Mar 5-8, 2015; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl):Abstract nr B20.
Abstract B27: Activin A induces vascular endothelial cell proliferation and angiogenesis in oral cancer
Authors: Oliveira Carine Ervolino de , Cervigne Nilva de Karla , Macedo Carolina Carneiro Souza , Leme Adriana Franco Paes , Graner Edgard , Coletta Ricardo Della 
Published: December 2015

Abstract
Solid tumors must develop direct and indirect ways to induce angiogenesis in order to continue progression and expansion. The expression of angiogenic factors in the tumor microenvironment is a complex process involving interactions among different cell types. Previous studies demonstrated activin A, a member of the TGF-β superfamily, participates in the development and progression of oral squamous cell carcinomas (OSCC) via regulation of the tumor microenvironment, but its effects in the modulation of angiogenesis are unknown. We examined whether activin A, recombinant or derivate from OSCC cells, promotes angiogenesis of the human umbilical vein endothelial cells (HUVECs). Activin A-treated cells increased tubulogenesis activity concomitantly with high cellular proliferation and low apoptosis. Conversely, follistatin, an activin A antagonist, and activin A knock down in HUVECs significantly inhibited proliferation, induced apoptosis and decreases tube formation. Similarly, conditioned media harvested from OSCC cells expressing high activin A levels increased the proliferative rate and the tubulogenic activity of HUVECs more than those obtained from OSCC cells expressing a shRNA to neutralize activin A expression. In conclusion, our results show that activin A derived from OSCC cells promotes endothelial cell proliferation and tumor angiogenesis, suggesting that activin A signaling could be an important target for tumor vascular disruption in oral cancer. Financial support: FAPESP #2013/19856-2 and #2013/01607-6.
Citation Format: Carine Ervolino de Oliveira, Nilva de Karla Cervigne, Carolina Carneiro Souza Macedo, Adriana Franco Paes Leme, Edgard Graner, Ricardo Della Coletta. Activin A induces vascular endothelial cell proliferation and angiogenesis in oral cancer. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers; Mar 5-8, 2015; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl):Abstract nr B27.
Abstract IA17: Influence on vessel shape of macrophage metabolism in the tumor hypoxic niche
Authors: Mazzone Massimiliano 
Published: December 2015

Abstract
Cancer typically has an inflammatory nature. Of all immune cells invading the tumor, the role of macrophages remains controversial because of their functionally distinct differentiation states. Classically activated (M1-like) macrophages and alternatively activated (M2-like) macrophages represent the two extremities of a continuum, in which the former are proinflammatory and tumoricidal, whereas the latter display pro-angiogenic and protumoral activities. This heterogeneity reflects the plasticity and versatility of these cells in response to microenvironmental signals. The tumor environment is constituted of cancer cells and stromal cells that coexist under different oxygen tensions and the influence of soluble factors. A plethora of (hypoxia-induced) cytokines and chemokines can define the macrophage phenotype and their positioning within the tumor. We have elucidated an elegant mechanism by which macrophages are recruited and retained in avascular hypoxic niches of the tumor, where they exert their immunosuppressive and pro-angiogenic activity. Hypoxia by itself indeed strongly affects macrophage function, as the cells are forced to adapt and alter their metabolism, which is accompanied by a drastic change in their transcriptome and proteome. We have found that the resultant metabolic changes drive macrophages towards a pro-angiogenic phenotype in an attempt to restore oxygenation. Soluble factors derived from the tumor exacerbate this macrophage shift by further enforcing this metabolic adaptation. As a consequence, tumor blood vessels are abnormal and dysfunctional, thus perpetuating hypoxia, which in turn fosters metastasis. By using genetic tools in mice, we show that inhibiting macrophage recruitment in hypoxic niches, or altering their metabolic and energetic state can break this feed-forward loop, resulting in normalized blood vessels and thus, strongly reducing metastatic dissemination.
Citation Format: Massimiliano Mazzone. Influence on vessel shape of macrophage metabolism in the tumor hypoxic niche. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers; Mar 5-8, 2015; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl):Abstract nr IA17.
From Reduction to Apocope: Final Poststressed Vowel Devoicing in Brazilian Portuguese
Authors: Meneses Francisco , Albano Eleonora 
Published: December 2015

Abstract
This is a study of final poststressed vowel devoicing following /s/ in Brazilian Portuguese. We contradict the literature describing it as deletion by arguing, first, that the vowel is not deleted, but overlapped and devoiced by the /s/, and, second, that gradient reduction with devoicing may lead to apocope diachronically. The following results support our view: (1) partially devoiced vowels are centralized; (2) centralization is inversely proportional to duration; (3) total devoicing is accompanied by lowering of the /s/ centroid; (4) the /s/ noise seems to be lengthened when the vowel is totally devoiced; (5) aerodynamic tests reveal that lengthened /s/ has a final vowel-like portion, too short to be voiced; (6) lengthened /s/ favors vowel recovery in perceptual tests. This seems to be a likely path from reduction to devoicing to listener-based apocope.
Na pista do crime: o policial argentino como gênero em Betibú
Authors: Lusvarghi Luiza 
Published: December 2015

<p>Entre 2010 e 2014, o policial argentino viveu um de seus períodos mais efervescentes, com “O Segredo dos seus olhos” (2010), de Juan José Campanella, que conquistou um Oscar, “Tese sobre um homicídio” (2013), de Hernán Goldfrid, êxito de bilheteria e crítica, e “Betibú” (2014), de Michel Cohen, película que lança um novo olhar sobre o gênero e sobre a realidade do país. A narrativa policial na Argentina está ligada à tradição literária, que teve em Jorge Luís Borges e Bioy Casares fortes defensores, de um lado, e de outro ao desenvolvimento da indústria cinematográfica, entre 1933 a 1942, com destaque para “<em>Fuera de la ley</em>” (1937), de Manuel Romero. A trama de investigação com toque <em>noir</em> está presente em “Betibú”, que mescla elementos do gênero criminal e de suspense, e critica a mídia e a vida nas cidades globais.</p><p><strong>Palavras-chave</strong>: Ficção policial; <em>neonoir</em>; neopolicial; cinema argentino; cinema brasileiro.</p>
Characteristics and predictors of allergic rhinitis undertreatment in primary care
Authors: Spinozzi F , Murgia N , Baldacci S , Maio S , Pala AP , Casciari C , dell’Omo M , Viegi G ,   on behalf of ARGA study group
Published: December 2015

Although allergic rhinitis is considered a raising medical problem in many countries it is often undertreated. The reasons for this phenomenon are not completely clear. The aim of this study is to evaluate factors associated with allergic rhinitis under-/no treatment. A sample of 518 allergic rhinitis patients recruited by their primary care physicians, as a part of the ARGA study, were invited to fill in a specific questionnaire regarding rhinitis symptoms, treatment, and rhinitis-related work/social disability. Chi-square test and logistic regression were performed to assess risk factors for allergic rhinitis under-/no treatment. Over one out of four patients had no treatment despite the symptoms and 13.5% were inadequately treated. Participants with asthma (OR 0.47, 95% CI 0.30–0.75) and conjunctivitis (0.44, 95% CI 0.27–0.71) were at lower risk of allergic rhinitis under-/no treatment: in asthmatics this reduction was related mainly to the concomitant asthma treatment (OR 0.19, 95% CI 0.10–0.37). Asthmatics with under-/not treated rhinitis had the highest prevalence of rhinitis-related quality of life impairment. Under-/no treatment for allergic rhinitis is still rather frequent despite the relevance of this disease. The simultaneous presence of asthma and an anti-asthmatic therapy are able to influence positively the treatment. Targeted interventions toward a better characterization and a tight follow-up of rhinitis patient without asthma are needed.
Assessment of premature atherosclerosis in systemic lupus erythematosus patients with and without nephritis
Authors: Sharma S K , Rathi M , Sahoo S , Prakash M , Dhir V , Singh S 
Published: December 2015

Background Risk of subclinical atherosclerosis is increased in patients with systemic lupus erythematosus (SLE). We correlated carotid intima media thickness (CIMT) and endothelial dysfunction through flow-mediated dilation (FMD) in SLE patients with the SLE Disease Activity Index (SLEDAI). Methods This single-centre cross-sectional study recruited 100 consenting SLE outpatients (ACR 1997 criteria) out of which 50 had nephritis, with disease duration of ≥2 years for SLE and ≥6 months for lupus nephritis. We measured baseline laboratory levels, CIMT and FMD (after brachial BP cuff inflation up to 200 mmHg for five minutes), and calculated SLEDAI. Results Mean age was 29.88 ± 6.53 years; 95/100 were female. CIMT showed positive correlation ( p = 0.037; rho = 0.209), and FMD showed inverse correlation with patient’s age ( p = 0.011; rho = –0.252). CIMT and FMD were more deranged in patients aged ≥25 years ( p < 0.05). CIMT was not significantly different between SLE patients with and without nephritis ( p > 0.05), whereas SLEDAI and FMD were more deranged in nephritis patients ( p < 0.05). In patients without nephritis, FMD showed significant inverse correlation with disease duration ( p = 0.043; rho = –0.288) and urine albumin ( p = 0.045; rho = –0.285). In nephritis patients, the correlation between age of the patient was significantly positive with CIMT ( p = 0.001; rho = 0.441) and significantly inverse with FMD ( p = 0.028; rho = –0.312). Conclusion SLE patients with nephritis are at a higher risk to develop arterial stiffening, leading to early end-organ damage. Early aggressive treatment may prevent endothelial dysfunction. FMD using vascular ultrasonography on the brachial artery represents a non-invasive, repeatable and useful method for the assessment of endothelial dysfunction.