bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activation
Authors: Bernier Elsa , Couture Camille , Borchers Anna , Brien Marie-Eve , Graham Charles H , Girard Sylvie 
Published: September 2024

Abstract
Pre-eclampsia (PE) affects 5–8% of pregnancies and has detrimental effects on maternal–fetal health. PE is characterized by de novo hypertension after 20 wk of gestation and end-organ damage. Systemic inflammatory imbalance has been associated with PE, but its contribution to the pathology is poorly understood. Our objective was to investigate maternal systemic immune changes in early-onset PE (EOPE) and late-onset PE (LOPE) versus uncomplicated pregnancies (control [CTRL]), and their contribution to endothelial activation, hallmark of hypertension. Blood samples were analyzed by flow cytometry, multiplex assay, intracellular cytokine staining, and single-cell RNA sequencing. We performed cocultures between circulating immune cells and HUVECs to assess endothelial activation. We found that EOPE had decreased regulatory T cells (4.64±0.33, p &lt; 0.05) and monocytes (33.92±3.08, p &lt; 0.01), whereas LOPE had decreased regulatory T cells (4.60±0.30, p &lt; 0.05) and Th2 cells (7.50±0.62, p &lt; 0.01) versus CTRL. Compared to CTRL, elevated cytokines/chemokines, and growth factors were observed in LOPE, whereas EOPE primarily showed decreased levels. Using intracellular cytokine staining, we observed more monocytes producing IL-12, TNF-α, and IL-1β (all p &lt; 0.05) in LOPE versus CTRL. At the transcriptomic level, we found differentially expressed genes between EOPE and CTRL, predominantly related to upregulation of immune activation pathways. Lastly, EOPE PBMCs induced heightened endothelial activation in vitro observed by increased ICAM-1 and ET-1 (p &lt; 0.05), whereas LOPE PBMCs required LPS stimulation. Although significant proteomic changes are observed in the LOPE group, the EOPE displayed changes mostly at the transcriptomic levels and could induce endothelial activation in vitro.
Assessment of the Remineralizing Efficacy of Grape Seed Extract vs Sodium Fluoride on Surface and Subsurface Enamel Lesions: An In Vitro Study
Authors: Sharma Deepak , Sahu Yogesh , Srichand Reema , Mhatre Swapnali , Shetty Uttam , Karhale Nikhil A. , Acharya Sonu 
Published: September 2024

ABSTRACT

Background:
Dental caries is a prevalent oral health issue, primarily resulting from demineralization of the enamel. Remineralizing agents such as sodium fluoride (NaF) have been widely used to counteract this process. Recent studies suggest that natural extracts, such as grape seed extract (GSE), may also have significant remineralizing properties. This study aims to compare the efficacy of GSE and NaF on surface and subsurface enamel lesions in an in vitro setting.

Materials and Methods:
In this in vitro study, 60 extracted human premolars were randomly divided into three groups of 20 each: control (no treatment), NaF treatment, and GSE treatment. Artificial enamel lesions were created on the buccal surfaces of all samples. The NaF group was treated with a 5% sodium fluoride solution, while the GSE group received a 6.5% grape seed extract solution. Treatments were applied daily for 10 days. Surface microhardness (SMH) and cross-sectional microhardness (CSMH) were measured before and after treatment to assess remineralization.

Results:
The NaF group showed a significant increase in SMH (45%) and CSMH (35%) compared to the control group. The GSE group demonstrated a similar trend with a 40% increase in SMH and a 30% increase in CSMH. Both treatments were significantly more effective than the control (P < 0.05), with no significant difference between the NaF and GSE groups (P > 0.05).

Conclusion:
Grape seed extract exhibits comparable remineralizing efficacy to sodium fluoride on both surface and subsurface enamel lesions in vitro. These findings suggest that GSE could be a viable natural alternative to fluoride for the prevention and treatment of dental caries.
Diagnostic Accuracy of 3T Magnetic Resonance Imaging and Arthroscopy in Triangular Fibrocartilage Complex Injury
Authors: Kesav Abhishek Sugumar , Dhandapani Balaji , Wahegaonkar Abhijeet L. 
Published: September 2024

Abstract

Introduction:
The advances in the understanding of wrist instability have enhanced the need for improved diagnostic modalities. 3T magnetic resonance imaging (MRI) with a small joint coil has emerged as a promising tool in determining ligamentous wrist injuries. Although arthroscopy remains the gold standard for diagnosis, the economics of the procedure, health insurance penetrance, and indemnity concerns, a noninvasive diagnostic tool with high accuracy is the need of the hour.

Materials and Methods:
Here, we have compared the accuracy of a 3T MRI for the diagnosis of triangular fibrocartilage complex (TFCC) tears against diagnostic wrist arthroscopy.

Results:
We found that 3T MRI with small joint coils has high sensitivity and specificity in the diagnosis of foveal avulsions of TFCC. By virtue of direct visualization, arthroscopy has the ability to differentiate scar, enema, and/or hematoma from an intact ligament as compared to MRI.

Conclusion:
Therefore, a good quality MRI (3T MRI, small joint coil, taken in proper plane and position with thin cuts) would improve the likelihood of an accurate diagnosis and reduce the burden on the health-care system.
Functional Outcomes of Quadruple Nerve Transfer in Upper Brachial Plexus Injuries
Authors: Bandari Gopinath , Quadri Syed Mohd Noaman 
Published: September 2024

Abstract

Background:
Brachial plexus injuries represent a devastating injury causing paralysis of the upper extremity. An injury to the superior plexus can cause loss of function in the shoulder and elbow. Early presentations can be well managed with nerve transfers to restore shoulder and elbow function. Our study aimed to evaluate the functional outcome of nerve transfers to restore shoulder and elbow recovery in upper brachial plexus injury.

Methods:
Functional outcomes of 25 patients undergoing quadruple nerve transfer using an all-anterior approach were analyzed for improvements in motor strength and range of motion in the shoulder and elbow joints.

Results:
Excellent results were observed in 23/25 patients with respect to elbow function and good in 15/25 for shoulder function. The first sign of clinical biceps reinnervation was 3 months 9 days (range: 2 months from 25 days to 4 months) and recovery of antigravity elbow flexion was 5 months (range 4 months–8 months). Twenty-two had M4 power and two M3. On assessment of shoulder function and abduction, eight patients had M3, and four had M4 shoulder abduction. The mean range of abduction in these eight patients was 60° (range, 45–100). Seven patients regained active external rotation, a mean of 30° (range, 15–60). Motor recovery of external rotation was M3 in five patients and M4 in two. Of 25, 7 had no active abduction/external rotation but felt their shoulder was more stable.

Conclusion:
Quadruple nerve transfer for shoulder function and elbow flexion produces the best results in patients with superior brachial plexus injuries. Surgeries performed earlier than 6 months can provide good functional recovery. The result on the shoulder is less compared to the functional recovery of the elbow after nerve transfer.
Modelling Approach of Thermal Runaway Propagation and Gas Venting Process in Lithium-Ion Batteries: A Comprehensive Review
Authors: Nogdhe Yogesh , Garg Ravi , Singh Shobit Kumar 
Published: September 2024

<div class="section abstract"><div class="htmlview paragraph">With the growing popularity of electric vehicles (EVs) Lithium-ion batteries (LIBs) exhibit unique characteristics such as long life, high specific energy, significant storage capacity, and remarkable energy density. The continual difficulty temperature non-uniformity over the battery surface and inside the battery pack, remains a major barrier in battery technology, significantly contributing to the tendency towards Thermal Runaway (TR). The hot gases discharged from a lithium-ion cell’s safety vent during a thermal runaway event carry flammable elements. If ignited, these gases heighten the potential for thermal runaway to spread to other cells within a multi-cell pack configuration. The study scrutinizes the effects of TR on the venting process. It explores contemporary approaches to minimize it, employing a variety of modeling methodologies such as Multiphysics, Computational Fluid Dynamics (CFD), and electrochemical-thermal, in addition to experimental methods. The objective of this study is to gain a deeper understanding of the intricate aspects of battery Thermal Runaway Propagation (TRP) and gas venting. TR and venting both are key Li-ion battery problem, that raises safety concerns. Efficient modelling is critical for creating prediction and detectable strategies. This comprehensive analysis emphasizes the importance of TRP and gas venting modelling for forecasting and improving battery system safety measures.</div></div>
ON TEACHING RUSSIAN GRAMMAR TO AN IRANIAN AUDIENCE: APPROACHES, METHODS AND PROBLEMS
Authors: ИСКАНДАРИ М.П. 
Published: September 2024

Преподавание русской грамматики в иранской аудитории считается одним из важнейших аспектовобучения русскому языку в Иране. В статье рассматриваются подходы и методы, применяемые к обучению грамматике русского языка, а также причины использования таких методов на занятиях с персоговорящими студентами. Автор акцентирует внимание на путях повышения эффективности обучения русской грамматике в иранской аудитории, также рассматривает некоторые возникающие в связи с этим барьеры. Делается вывод о том, что, учитывая ограничение в количестве выделяемого времени для обучения русской грамматике, языковой уровень персоговорящих учащихся, их возраст, цель обучения русскому языку и значительные различия между русскими и персидскими грамматическими правилами, иранские преподаватели предпочитают использовать эксплицитные методы при преподавании русских грамматических правил. Кроме того, преподавание русской грамматики в иранской аудитории ведется на трех ступенях, включая: 1) предоставление грамматической информации и правил; 2) работа над предоставленным материалом на занятии; 3) домашнее задание. По мнению автора, необходимым звеном обучения русской грамматике в иранской аудитории является четвертая ступень, т.е. ступень закрепления грамматического материала, отсутствующая в самом процессе обучения этому предмету. Пройденный материал закрепляется после изучения всей грамматики в шестом семестре, когда сами грамматические правила уже почти забываются студентами.
Teaching Russian grammar to an Iranian audience is considered one of the most important problems in teaching the Russian language in Iran. The article discusses the approaches and methods used to teach Russian grammar and the reasons for using such methods in classes with Persian-speaking students. The author focuses on ways to improve the effectiveness of teaching Russian grammar in Iranian audiences, and also examines the barriers on this path. It is concluded that given the limited amount of teaching time for teaching Russian grammar, the language level of Persian-speaking students, their age, the purpose of teaching Russian and the strong discrepancy between Russian and Persian grammars, Iranian teachers prefer to use explicit methods when teaching Russian grammar rules. And the teaching of Russian grammar in Iranian audiences takes place in three stages, including 1) the stage of providing grammatical information and rules, 2) the stage of working on the provided material in class, and 3) the stage of homework. Today, the missing link in teaching Russian grammar in Iranian audiences is considered to be the absence of the fourth stage, i.e. stage of consolidation of grammatical material. This stage does not take place in the process of teaching this subject and occurs at another time after the completion of all grammatical rules in the sixth semester, when the grammatical rules have been forgotten by the students.
Pengaruh Pengalaman, Tekanan Ketaatan, Independensi, dan Self Efficacy Terhadap Audit Judgement
Authors: Hapsari Atiqatul Ulya , Saraswati Esti , Kristianto Giovanny Bangun 
Published: September 2024

Auditor dalam membuat keputusan dan mengeluarkan opini atas informasi maupun bukti yang telah diperoleh memerlukan audit judgement. Ketepatan auditor dalam mengeluarkan audit judgement perlu dioptimalkan dengan mencermati aspek yang dapat mempengaruhi audit judgement. Penelitian ini bertujuan untuk mengetahui adanya pengaruh dari pengalaman, tekanan ketaatan, independensi, dan self efficacy terhadap audit judgement. Penelitian ini merupakan termasuk kategori kuantitatif dengan populasinya adalah auditor yang telah bekerja di KAP wilayah Jawa Barat. Jumlah responden sebanyak 110 dari KAP wilayah Jawa Barat yang terdaftar di Direktori IAPI tahun 2023. Nantinya pada proses penyusunan penelitian ini akan digunakan snowball sampling sebagai teknik pengambilan sampel. Sementara itu, untuk teknik analisis data yang peneliti gunakan adalah analisis regresi linier berganda. Berdasarkan hasil analisis yang telah dilakukan menggunakan alat bantu SPSS versi 25, didapatkan hasil variabel pengalaman, independensi, dan self efficacy memiliki pengaruh kearah positif terhadap audit judgement. Variabel tekanan ketaatan tidak mempunyai pengaruh terhadap audit judgement. Sedangkan empat variabel tersebut secara simultan memiliki pengaruh terhadap audit judgement.
Analisis Implementasi Three Way Matching Dalam Meningkatkan Kualitas Sistem Informasi Akuntansi (Pada CV Migaspro Energia)
Authors: Syafira Rifa , Rizqi Muhammad Nur , Rumiasih N. A. 
Published: September 2024

The purpose of this study is to assess the implementation of Three Way Matching as well as the quality of CV Migaspro Energia's accounting information systems. Qualitative descriptive analysis was employed in the study. This study's data collection techniques included documentation, observation, and interviews. Based on the findings of the research, the finance department of CV Migaspro Energia implemented Three Way Matching and created three documents required for this process purchase order data, goods receipt data, and buy invoice data. Implementing Three Way Matching can help CV Migaspro Energia improve the quality of its accounting information systems. It can be seen from before and after use because by using this method, the problem of data discrepancies, payment errors, and lack of transparency in the audit process has rarely occurred in companies, whereas these problems frequently occurred in companies prior to this application, allowing the quality of the company's accounting information system to improve by producing reliable financial statements. The Three Way Matching process is still manual and not automated by the Three Way Matching support program.
Fluorescence properties of long-range transported smoke: Insights from five-channel lidar observations over Moscow during the 2023 wildfire season
Authors: Veselovskii Igor , Korenskiy Mikhail , Kasianik Nikita , Barchunov Boris , Hu Qiaoyun , Goloub Philippe , Podvin Thierry 
Published: September 2024

Abstract. The fluorescence lidar at the Prokhorov General Physics Institute (Moscow) was utilized to study transported smoke during the wildfire season from May to September 2023. The lidar system, based on a tripled Nd:YAG laser, performs fluorescence measurements at wavelengths of 438, 472, 513, 560, and 614 nm. This configuration enables the assessment of the spectral dependence of fluorescence backscattering from the planetary boundary layer (PBL) to the upper troposphere and lower stratosphere (UTLS). The fluorescence capacity of smoke, defined as the ratio of fluorescence backscattering to aerosol backscattering at the laser wavelength, exhibits significant variation in the UTLS, with changes of up to a factor of 3. This variation is likely indicative of differences in the relative concentration of organic compounds within the smoke. Analysis of more than 40 smoke episodes enabled an evaluation of the height dependence of smoke fluorescence properties. Observations reveal that the fluorescence capacity generally increases with altitude, suggesting a higher concentration of organic compounds in the UTLS compared to the lower troposphere. Additionally, the measurements consistently show differences in the fluorescence spectra of smoke and urban aerosol. Urban aerosol fluorescence tends to decrease gradually with wavelength, whereas the peak of smoke fluorescence is observed at the 513 or 560 nm channels. This spectral distinction provides an effective means of separating smoke from urban aerosol. The technique was applied to events where smoke from the upper troposphere descended into the PBL and mixed with urban particles, demonstrating its utility in distinguishing between these aerosol types.
ICON ComIn – The ICON Community Interface (ComIn version 0.1.0, with ICON version 2024.01-01)
Authors: Hartung Kerstin , Kern Bastian , Dreier Nils-Arne , Geisbüsch Jörn , Haghighatnasab Mahnoosh , Jöckel Patrick , Kerkweg Astrid , Loch Wilton Jaciel , Prill Florian , Rieger Daniel 
Published: September 2024

Abstract. In 2021, a team of developers from the Deutscher Wetterdienst (DWD), the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR), the German Climate Computing Center (Deutsches Klimarechenzentrum, DKRZ) and the Forschungszentrum Jülich (FZJ) started the Icosahedral Nonhydrostatic (ICON) Model Community Interface (ComIn) project: ICON ComIn is a library with multi-language support for connecting third-party modules ('plugins') to the ICON model using the dynamic loader of the operating system. ComIn is intended for a wide range of use cases, from the integration of simple diagnostic Python scripts to full chemistry models into ICON. ICON ComIn is distributed with the ICON model code under an open source license. Its application programming interface (API) provides a low barrier for code extensions to ICON and reduces the migration effort in response to new ICON releases. ComIn's main design principles are that it is lightweight, interoperable (Fortran, C/C++, Python) and flexible, and required changes in ICON are minimised. During the development of ComIn the ease of getting started and the experience during plugin development were guiding principles to provide a convenient tool. The extensive documentation and a variety of test and example plugins are results of this process. This paper motivates the underlying design principles and provides some concrete reasoning for their selection. Further, current limitations are discussed and the vision for the future is presented.
Experience of micropulse transscleral cyclophotocoagulation in glaucoma with decompensated intraocular pressure
Authors: Malyshev A. V. , Apostolova A. S. , Sergienko A. A. , Teshev A. F. , Karapetov G. Yu. , Ashkhamakhova M. K. , Khatsukova B. N. 
Published: September 2024

PURPOSE. To evaluate the effectiveness of micropulse transscleral cyclophotocoagulation (MP-TSCPC) in patients with decompensated glaucoma.METHODS. The analysis included a total of 54 eyes with decompensated glaucoma that underwent MP-TSCPC. The mean age was 62.83±1.75 years. The follow-up period lasted up to 3 months. Advanced-stage glaucoma was observed in 18 eyes, and terminal-stage glaucoma in 34 eyes. Primary glaucoma was present in 37 eyes, and secondary glaucoma in 14 eyes. A reduction in intraocular pressure (IOP) of more than 20% from baseline was considered a successful outcome.RESULTS. The baseline IOP was 38.97±1.94 mm Hg, with an overall hypotensive effect of 26%. The overall effectiveness of mCPC was 75.9%.In terminal-stage glaucoma, IOP reduction by the end of the third month after MP-TSCPC was 23%, with an effectiveness of 76.5%. In advanced-stage glaucoma, IOP decreased by 16% by the end of the third month, with an effectiveness of 75%.For primary glaucoma, the IOP reduction at 3 months was 32.5%, and for secondary glaucoma, it was 22%. Prior to MP-TSCPC, patients had been using an average of 3.075 types of eye drops, which remained unchanged after the procedure. The effectiveness of MP-TSCPC did not differ between operated and non-operated eyes. When MP-TSCPC was performed to relieve pain, success was achieved in all cases. During the study period, one patient underwent a repeat MP-TSCPC, and another underwent an antiglaucoma filtering surgery. No complications were observed in any of the cases.CONCLUSION. MP-TSCPC is an effective intervention with a safe early postoperative period. We observed a significant hypotensive effect in eyes with preserved visual function and effective pain relief. Further follow-up of these patients is necessary, as well as the expansion of indications for use in earlier stages.
Comparative outcomes of topical and laser treatment in newly diagnosed patients with primary glaucoma
Authors: Anisimova S. Yu. , Anisimov S. I. , Kochmala O. B. , Ling Peng , Vokuev M. A. , Gavrilova N. A. 
Published: September 2024

PURPOSE. To conduct a comparative evaluation of the efficacy and safety of medication-based hypotensive therapy versus selective laser trabeculoplasty (SLT) in patients with newly diagnosed primary open-angle glaucoma (POAG).METHODS. The study included 59 patients with POAG (59 eyes), divided into two groups. Group 1 received monotherapy with tafluprost, while Group 2 underwent SLT. In cases of intraocular pressure (IOP) decompensation during the follow-up period, Group 1 was prescribed additional topical therapy or switched to SLT, and Group 2 was started on topical therapy. The follow-up lasted 6 months. The study assessed the hypotensive efficacy of the treatments and the condition of visual functions.RESULTS. By the end of the observation period, the hypotensive efficacy in Group 1 was 24%, with an IOP level of 20.1±1.6 mm Hg. Some adverse effects related to topical therapy were observed. In Group 2, the hypotensive efficacy was 20.5%, with an average IOP level of 16.8±2.0 mm Hg. No adverse events were reported in Group 2.CONCLUSION. Preliminary outcomes indicate that the hypotensive efficacy of monotherapy with prostaglandin analogues and SLT is comparable. The clear advantages of laser treatment include reduced adverse effects, which promotes better compliance, adherence to treatment, and decreased risk of disease progression.
ALIRAN ASY'ARIYAH (Kajian Historis dan Pengaruh Aliran Kalam Asy’ariyah)
Authors: Hasibuan Hadi Rafitra 
Published: September 2024

Asy'ariyah rapidly developed from the 11th century AD. Together with the spread of Sufism (Sufi), this understanding also gained support by rulers in several Islamic governments. Ash'ariyah became the official school of the Gaznawi dynasty in India in the 11th-12th century that caused this understanding to spread from India, Pakistan, Afghanistan, to Indonesia. Asy'ariyah's understanding is very strong in the body of Muslims and the aqidah continues to spread among Muslims. They do not realize that their understanding is a deviation from the auspices of Ahlus Sunnah wal Jamaah, a new idea that exists after the end of the main generation of people: companions, tabi'in, and tabi'in.
PEMIKIRAN POLITIK ISLAM IMAM AL-MAWARDI DAN RELEVANSINYA DI INDONESIA
Authors: Syam Syafruddin 
Published: September 2024

As is known that the Islamic world in the past many produces great figures and thinkers whose names and works are still used and used as references in the face of various situations and problems that occur in the context of Muslim life. Khazanah Islamic intellectuals Abbasid caliphate era ever carved a golden history with the advancement of science and religious thought. One of the leading figures as well as the thinker and founder of the Islamic political scholarship of the Abbasid progress was Al-Mawardi.