bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Assessment of Empirical Thinking in Islam
Authors: Kusuma Kumara Adji 
Published: September 2024

This research explores the intersection between empiricism and Islamic epistemology, focusing on the limitations of sensory perception in capturing reality. Although empiricism plays an important role in Islamic thought, its exclusive reliance on sensory experience limits the understanding of phenomena beyond perception. Through a comparative analysis of Islamic philosophical texts and empirical literature, this study reveals the compatibility of empirical inquiry with metaphysical insights in Islam. By advocating a holistic approach to acquiring knowledge, this research contributes to the broader philosophical discourse, emphasizing the synthesis of empirical methods with spiritual insights for a comprehensive understanding of reality.
Highlights :

Empirical limitations: Highlighting the constraints of sensory perception in grasping reality.
Compatibility of methodologies: Demonstrating the harmony between empirical inquiry and Islamic metaphysical principles.
Synthesis of knowledge: Advocating for a holistic approach that integrates empirical methods and spiritual insights for a comprehensive understanding of reality.

Keywords: Empiricism, Islamic epistemology, Sensory perception, Metaphysical insights, Holistic approach
Government's Role in TPA Waste Management
Authors: Alfi Lisa Dwi , Mursyidah Lailul 
Published: September 2024

This study investigates the government's role in waste management at Jabon TPA, Jabon District, Sidoarjo. Employing a descriptive qualitative approach, data collection involves interviews, observation, and documentation, utilizing purposive sampling. The analysis encompasses data collection, reduction, analysis, and conclusion drawing. The findings reveal effective and smooth execution of the government's role in waste management, as evidenced by the fulfillment of various indicators. The study's concise yet comprehensive nature provides valuable insights into the successful governance of waste management practices, offering implications for broader contexts and policy considerations
Highlight :

The study employs a qualitative approach to investigate the government's role in waste management at Jabon TPA, providing valuable insights into the effectiveness of governance practices.
Data collection through interviews, observation, and documentation, utilizing purposive sampling, ensures a comprehensive and thorough examination of the waste management scenario.
The findings demonstrate the successful fulfillment of government roles, marking a significant contribution to the discourse on efficient waste management practices and policy considerations

Keywords: Waste Management, Government Role, Descriptive Research, Qualitative Approach, Jabon TPA
Implementation of Pamsimas: Realizing the Sustainability of Drinking Water and Sanitation in Villages
Authors: Pane Chairunnas , Mursyidah Lailul 
Published: September 2024

The purpose of this study is to assess the implementation of Community-Based Drinking Water and Sanitation Provision (Pamsimas) in Sidomulyo Village, Krian District, Sidoarjo Regency. This qualitative research provides an overview of the implementation process in the village. Data was collected through observation, interviews, and documentation, and analyzed using data reduction, data presentation, and data verification techniques proposed by Miles and Huberman. The results indicate that communication, resources, disposition, and bureaucratic structure are key indicators of Pamsimas implementation in Sidomulyo Village. Communication is smooth, resources are sufficient, residents are committed, and the bureaucratic structure adheres to standard operating procedures. These findings have implications for the successful implementation of Pamsimas in similar contexts, highlighting the importance of effective communication, adequate resources, community engagement, and adherence to standard procedures
Highlight :

Effective communication is a key indicator of successful Pamsimas implementation.
Adequate resources are necessary for the implementation of Pamsimas.
Adherence to standard operating procedures is crucial for the successful implementation of Pamsimas.

Keywords: Pamsimas, implementation, community-based, drinking water, sanitation.
Enhancing Financial Report Quality in Indonesia Through HR, Standards, and Controls
Authors: Setiawan M. Rizal , NURASIK  
Published: September 2024

This study investigates the impact of Human Resources (HR) quality, Government Accounting Standards (SAP) implementation, and Internal Control Systems (SPI) on the financial report quality at the Taman District Office in Sidoarjo Regency. Using a sample of 54 employees and a quantitative approach, data were collected via questionnaires and analyzed with multiple linear regression. Findings show that HR quality, SAP implementation, and SPI significantly influence financial report quality both individually and collectively, with a combined impact of 65.5%. Specifically, HR quality contributes 32%, SAP implementation 36.7%, and SPI 37.3%. To enhance financial report quality, improvements in HR, SAP application, and SPI are recommended.
Highlight:

HR quality, SAP implementation, and SPI significantly influence financial report quality.
Combined impact of these factors on report quality is 65.5%.
HR quality, SAP, and SPI contribute 32%, 36.7%, and 37.3%, respectively.

Keywoard: Financial reports, Human resources, Government Accounting Standards, Internal Control Systems, Taman District Office
Leadership and Rewards Drive Performance-Based Budgeting in Indonesia
Authors: Sunari Sunari , Biduri Sarwenda 
Published: September 2024

This research investigates the impact of organizational commitment, human resource quality, leadership style, and rewards on performance-based budgeting in Sidoarjo Regency's local government agencies. Using a quantitative approach and surveying 100 employees, data were collected via closed questionnaires and analyzed using SPSS Statistics software version 26. Results show that while organizational commitment has an insignificant impact, leadership style and rewards significantly influence performance-based budgeting, and human resource quality has no effect. These findings highlight the importance of effective leadership and reward systems in enhancing budget implementation. Limitations include a restricted sample size, suggesting further research with broader scope and additional variables.
Highlight:

Leadership Impact: Leadership style significantly affects performance-based budgeting implementation.
Rewards Role: Rewards enhance employees' performance and budget implementation.
Human Resources: Quality of human resources does not impact budget implementation.

Keywoard: Organizational Commitment, Human Resource Quality, Leadership Style, Rewards, Performance-Based Budgeting
BPPV Nystagmus Signals Diagnosis Framework Based on Deep Learning
Authors: Liu ZhiChao , Wang YiHong , Zhu Mingzhu , Zhang JianWei , He Bingwei 
Published: September 2024

Abstract

Benign Paroxysmal Positional Vertigo (BPPV) is a prevalent vestibular disorder encountered in clinical settings. Diagnosis of this condition primarily relies on the observation of nystagmus, which involves monitoring the eye movements of patients. However, existing medical equipment for collecting and analyzing nystagmus data has notable limitations and deficiencies. To address this challenge, a comprehensive BPPV nystagmus data collection and intelligent analysis framework has been developed. Our framework leverages a neural network model, Egeunet, in conjunction with mathematical statistical techniques like Fast Fourier Transform (FFT), enabling precise segmentation of eye structures and accurate analysis of eye movement data. Furthermore, an eye movement analysis method has been introduced, designed to enhance clinical decision-making, resulting in more intuitive and clear analysis outcomes. Benefiting from the high sensitivity of our eye movement capture and its robustness in the face of environmental conditions and noise, our BPPV nystagmus data collection and intelligent analysis framework has demonstrated outstanding performance in BPPV detection.
A Systematic Review of Machine Learning in Robotics-Assisted Rehabilitation
Authors: Nicora Giovanna , Pe Samuele , Santangelo Gabriele , Billeci Lucia , Aprile Irene Giovanna , Germanotta Marco , Bellazzi Riccardo , Parimbelli Enea , Quaglini Silvana 
Published: September 2024

Abstract

Robotic technology is expected to transform rehabilitation settings, by providing precise, repetitive, and task-specific interventions, thereby potentially improving patients’ clinical outcomes. Artificial intelligence (AI) and machine learning (ML) have been widely applied in different areas to support robotic rehabilitation, from controlling robot movements to real-time patient assessment. To provide and overview the current landscape and the impact of AI/ML use in robotics rehabilitation, we performed a systematic review focusing on the use of AI and robotics in rehabilitation from a broad perspective, encompassing different pathologies and body districts, and considering both motor and neurocognitive rehabilitation. We searched the Scopus and IEEE Xplore databases, focusing on the studies involving human participants. After article retrieval, a tagging phase was carried out to devise a comprehensive and easily-interpretable taxonomy: its categories include the aim of the AI/ML within the rehabilitation system, the type of algorithms used, and the location of robots and sensors. The selected articles span multiple domains and diverse aims, such as movement classification, trajectory prediction, and patient evaluation, demonstrating the potential of ML to revolutionize personalized therapy and improve patient engagement. ML is reported as highly effective in predicting movement intentions, assessing clinical outcomes, and detecting compensatory movements, providing insights into the future of personalized rehabilitation interventions. Our analysis also reveals pitfalls in the current use of AI/ML in this area, such as potential explainability issues and poor generalization ability when these systems are applied in real-world settings.
Assessment of left atrium appendage morphology by 3D transesophageal echocardiography and itʼs relation to thrombus formation
Authors: Khalil Hend Ahmed , Sakr Sherif A , Sobh Hoda M 
Published: September 2024

Abstract

Objective: This study was to assess different LAA shapes by 3D TEE and to find the relationship between the morphology of the LAA and the incidence of SEC and thrombus formation.
Patients and methods: this is prospective cross sectional study included sixty patients underwent 2D & 3D TEE and assessed for LAA morphology and presence of SEC or thrombus.
Results: regarding different shapes of LAA we found21windsock (35.1%), 17 cactus (28.3%) ,11 chicken wing (18.3%)and 11 cauliflower 11(18.33%). Thrombus found in 3 cases (5.0%), SEC in 15 cases (25.0%). There is significant association between morphology of LAA and presence of SEC; which noticed only in non – chicken wing shapes (7 in cauliflower, 5 in windsock, 3 in cactus and 0 in chicken wing) . There is significant association between morphology of LAA and thrombus formation; the 3 thrombus were found in cactus (100%) and regarding number of LAA lobes that bi lobed were the most common in 41.66% of cases, then single lobed in 33.33% of cases and the least common were multi lobed.
There is significant relationship between shape of LAA and orifice area (p-value =0.009); cauliflower associated with the largest orifice area and chicken wing with the smallest orifice area. The cauliflower had the largest number of lobes 3-5, the smallest number of lobes associated with windsock 1-2.
Conclusion: 3D TEE provide detailed assessment of LAA shapes and it’s special anatomical characteristic. In our study, non-chicken wing LAA shapes was associated with higher prevalence of SEC and thrombus.
PCDH17 induces colorectal cancer metastasis by destroying the vascular endothelial barrier
Authors: Zhang Bin , Dong Fengyun , Zhou Pinghui , Kong Feifei , Cao Sijie , Pan Xiaozao , Cai Shujing , Chen Xinke , Wang Sen , Li Na , He Baoyu , Zhao Rou , Bie Qingli 
Published: September 2024

Abstract

Compromised vascular integrity facilitates the cancer cells extravasation and metastasis. However, the mechanisms leading to a disruption in vascular integrity in colorectal cancer (CRC) remain unclear. In this study, PCDH17 expression was higher in the vascular endothelial cells of colon cancer with distant metastasis, and the rates of PCDH17+ endothelial cells (ECs) was associated with the M stage in clinical pathological characteristics analysis and correlated with a poor survival prognosis. The liver and lung metastatic dissemination of MC-38 was significantly decreased in PCDH17–/–mice. The ubiquitination degradation of VEGFR2 was prevented by the interaction between PCDH17 and the E3 ubiquitin ligase MARCH5, which causing the separation of internalized VE-cadherin, then increasing the vascular permeability and metastasis of CRC. These results highlight the importance of PCDH17 in maintaining vascular integrity, which has emphasis for endothelial barrier function in metastatic cancer. PCDH17 has the potential to be a marker for predicting tumor metastasis as well as a viable treatment target for CRC.
Time to viral load re-suppression and predictors among adult patients on Second-line Anti- Retro Viral Therapy at Northeastern Ethiopia: A multi-centered Retrospective Follow-up study
Authors: Melaku Abebe Yehualaw , Cherie Niguss , Birhanu Tarikua Afework , Wudu Muluken Amare 
Published: September 2024

Abstract

Background
Despite the increasing number of patients on second-line antiretroviral therapy in Ethiopia, there is limited evidence regarding the time to viral re-suppression. Consequently, this study aimed to assess the time to viral load re-suppression and its predictors among adult patients on second-line antiretroviral therapy in Northeastern Ethiopia.
Method
A multi-centered, institution-based retrospective follow-up study was conducted, including 526 adults living with HIV who were on second-line ART in northeast Ethiopia. A Weibull proportional hazards model was fitted to identify predictors of viral re-suppression among adult patients on second-line antiretroviral therapy in Northeastern Ethiopia.
Result
The median time to viral re-suppression was 9 months (IQR = 3–15 months). Moreover, the rate of viral re-suppression was 44.3 per 1,000 person-months (95% CI: 40.4–49). Predictors of viral re-suppression included disclosure of HIV status [AHR 2.24 (95% CI: 1.4–3.7)], classification in WHO clinical stages I and II [AHR 6.9 (95% CI: 4.4–9.6)], receipt of TB preventive treatment [AHR 3.7 (95% CI: 2.3–5.93)], absence of first-line drug substitution history [AHR 1.44 (95% CI: 1.2–1.8)], and good adherence to treatment [AHR 1.9 (95% CI: 1.4–2.54)].
Conclusion and Recommendations
In this study, the time to viral load re-suppression was longer than expected. Health managers and ART care providers must improve the timing and effectiveness of early disclosure, encourage the early use of TB prophylaxis, and maintain good adherence through various strategies.
Enhancing Hepatocellular Carcinoma Therapy with DOX-Loaded SiO2 Nanoparticles via mTOR-TFEB Pathway Autophagic Flux Inhibition
Authors: Chen Huanyu , Liu Jun , Cao Zhichao , Li Jiajia , Zhang Hong , Yang Qianqian , Shen Yuxian , He Kewu 
Published: September 2024

Abstract

Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. To enhance the biosafety and reduce the side effects of these drugs, various nanocarrier delivery systems have been developed. In this study, we loaded the anticancer drug doxorubicin (DOX) and an MRI contrast agent into silica nanoparticles, coating them with pH-responsive and tumor cell-targeting polymers. These polymers enable the carrier to achieve targeted delivery and controlled drug release in acidic environments. This integrated diagnostic and therapeutic strategy successfully achieved both the diagnosis and treatment of liver cancer. Additionally, we demonstrated that the nanocarrier inhibits autophagic flux in liver cancer cells by targeting the autophagy-lysosome pathway and regulating the nuclear translocation of TFEB, thereby promoting tumor cell death. This novel diagnostic-integrated nanocarrier is expected to be a promising tool for targeted liver cancer treatment.
RETRACTED: Effect of erector spinae plane block on intravenous opioid consumption and postoperative pain in patients undergoing breast cancer surgery
Authors: GÜNEL BEDİRHAN , BALABAN ONUR , OKUMUS BUSRA EREN , KOCER HAVVA BELMA , ERDEM ALİ FUAT 
Published: September 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Assessment of Adherence to Self-Care Practices of Known Hypertensive Out-Patients in the Cardiology Unit of Tertiary Hospitals in South-Eastern Nigeria: A Cross-Sectional Study.
Authors: Anene-Okeke Chigozie Gloria , Omeje Ezinne Godsgift , Ikeanyi Chinelo Nneka 
Published: September 2024

Abstract

Background
Adherence is a primary determinant of the effectiveness of treatment as poor adherence attenuates optimum clinical benefit and paves the way for complications. The aim of the study was to assess adherence to self-care practices of hypertensive patients.
Results
About 297(59.4%) adhered to medication use, 259(59.4%) was adherent to low salt diet, 255(51.0%) adhered to physical activity while 300(60%) adhered to weight management self-care practices. Most of the patients 361(72.2%) were non- smokers, however, a lot of them consume alcohol 363(72.6%). Gender was associated medication use (X2 (1) = 7.152, p = 0.007) while educational level had an association with physical activity and smoking (X2 (3) = 31.898, p = 0.000).
Conclusion
The hypertensive patients had high level of self-care practices for hypertension, however, adherence to the DASH diet was low. The practice of exercise, and weight control was moderate. Patient-specific targeted interventions are required to improve self-care practices for hypertension. Improving self-management practices for hypertension requires targeted, patient-specific interventions.
Study on the foam production characteristics of air self-suction foam generator by jet
Authors: Lu Caiyuan , Wu Yuxin , zhu Di , Liang Yuntao 
Published: September 2024

Abstract

Confined space fires could easily cause serious casualties and property damage, and foam is an effective means of preventing confined space fires. The existing foam generator does not have both momentum and foam expansion rate (FER) and is poorly suited to confined spaces. In order to develop a foam generator suitable for confined space fire protection, an in-depth analysis of the physical foaming characteristics of self-suction foam is required, and the structure of the foam generator is optimized accordingly. For this reason, this paper analyzes the foaming characteristics and forming principle of air self-suction foam generator, and simulates and studies the over-current ratio of rectifying orifice plate with the help of Fluent software, φ (the ratio of the area of the fluid that can pass through the rectifier disk to the vertical cross-sectional area of the fluid flow), the distribution patterns of flow field, pressure, and turbulence intensity inside the foaming machine are determined by the nozzle cavity spacing and mixing cavity diameter. The study demonstrates that water flow is the most effective means of entraining air, and that the contact between the fluid and foam network is most thorough when the overflow ratio of the fan disc (φ) is 0.455, the distance between nozzle cavities μ (the distance between the nozzle and the closest end face of the foam chamber vertically.) is 200 mm, and the diameter of the mixing chamber (d) is 260 mm. These conditions are optimal for the foam generator. Experimental verification shows that the device has the strongest air entrainment capability at φ 0.455. The foam mesh number (m), foam mesh spacing (l), and number of layers of foam mesh (n) significantly impact the air self-solution foaming of the jet. These factors influence FER, range (L), foam stacking thickness (σ), and unfoamed liquid separation rate (γ, Foam solution not involved in the foaming process.), but the magnitude of their effect varies. Considering the four factors affecting foam production performance, the optimal effect is achieved when the foam mesh of 16, the foam mesh spacing of 3 cm, the foam mesh of 2 layers, the distance between the foam mesh and the nozzle is 22 cm and φ is 0.455. Under these conditions, the foaming ratio (FER) of the jet self-suction foaming machine is 42 times, with L at 13 m, σ at 7 cm, and γ at 0.15 L/s. A device has been developed for long-distance and high FER air self-suction of foam generator, which can significantly assist in fire prevention and extinguishing in confined spaces.
The impact of resection margins in primary resection of high grade soft tissue sarcomas: a single-center analysis of 203 patients
Authors: Steffens Julian Miles , Budny Tymoteusz , Gosheger Georg , Vaal Marieke , Rachbauer Anna Maria , Laufer Andrea , Engel Nina Myline , Deventer Niklas 
Published: September 2024

Abstract

Background:
The World Health Organization’s (WHO) classification of tumors contains around 80 entities of soft tissue sarcomas (STS). Till now surgery is the standard treatment for patients with localized STS but the adequacy of resection margins in soft tissue sarcomas (STS) remains a topic of intense discussion.
Methods:
This single-center study retrospectively reviewed 203 patients with primary high-grade soft tissue sarcoma, including a follow-up period of at least 24 months unless a local recurrence occurred earlier (1-170 months). Patients with prior resection, secondary STS, metastasis at presentation or those who required amputational surgery were excluded from the study. Patients were categorized based on their margin thickness: positive (n = 13, 6.4%), 0–1 mm (n = 67, 33.0%), 1–5 mm (n = 70, 34.5%), and > 5 mm (n = 27, 13.3%).
Results:
A total of 64 out of 203 (31.5%) patients developed a local recurrence. The estimated 5-year local recurrence-free survival (LRFS) was 11.5% (CI 4–25%) for positive margins, 58% (CI 51–64%) for margins 0–1 mm, 76% (CI 70–81%) for margins > 1–5 mm, and 93% (CI 88–98%) for margins > 5 mm. No local recurrences occurred in patients with margins > 5 mm and adjuvant radiotherapy. Margin status significantly influenced the development of distant metastasis and overall survival. Adjuvant radiotherapy improved both local control and overall survival.
Conclusions:
To minimize the risk of local recurrence (LR) and achieve near-complete local control, a resection margin greater than 5 mm should be attained. When adjuvant radiotherapy is applied, the likelihood of LR decreases even more. In scenarios where preserving critical structures is essential, a resection margin of less than 5 mm can be acceptable for ensuring local control. Achieving an R0 resection is imperative for ensuring distant metastasis-free survival and overall survival.