bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Proton Source in Electrocatalytic CO2 Reduction with [Mn(bpy–R)(CO)3Br] Complexes
Authors: Franco Federico , Cometto Claudio , Nencini Luca , Barolo Claudia , Sordello Fabrizio , Minero Claudio , Fiedler Jan , Robert Marc , Gobetto Roberto , Nervi Carlo 
Published: January 2017

AbstractThe electrochemical behavior of fac‐[Mn(pdbpy)(CO)3Br] (pdbpy=4‐phenyl‐6‐(phenyl‐2,6‐diol)‐2,2′‐bipyridine) (1) in acetonitrile under Ar, and its catalytic performances for CO2 reduction with added water, 2,2,2‐trifluoroethanol (TFE), and phenol are discussed in detail. Preparative‐scale electrolysis experiments, carried out at −1.5 V versus the standard calomel electrode (SCE) in CO2‐saturated acetonitrile, reveal that the process selectivity is extremely sensitive to the acid strength, producing CO and formate in different faradaic yields. A detailed spectroelectrochemical (IR and UV/Vis) study under Ar and CO2 atmospheres shows that 1 undergoes fast solvolysis; however, dimer formation in acetonitrile is suppressed, resulting in an atypical reduction mechanism in comparison with other reported MnI catalysts. Spectroscopic evidence of Mn hydride formation supports the existence of different electrocatalytic CO2 reduction pathways. Furthermore, a comparative investigation performed on the new fac‐[Mn(ptbpy)(CO)3Br] (ptbpy=4‐phenyl‐6‐(phenyl‐3,4,5‐triol)‐2,2′‐bipyridine) catalyst (2), bearing a bipyridyl derivative with OH groups in different positions to those in 1, provides complementary information about the role that the local proton source plays during the electrochemical reduction of CO2.
Sorption of Hg(II) and Zn(II) ions using lignocellulosic sorbent (date pits)
Authors: Rezgui Amina , Guibal Eric , Boubakera Taoufik 
Published: January 2017

AbstractThis work focuses on the study of Hg(II) and Zn(II) sorption using pristine date pits. The effect of pH is evaluated before considering the influence of both temperature and contact time on sorption efficiency. Sorption isotherms are also determined and modelled using conventional models such as Langmuir, Freundlich, and Dubinin‐Radushkevich (D‐R) equations. The best fit was obtained with the Langmuir equation and maximum sorption capacities reached 38.5 and 52.6 mg · g−1, for Hg(II) and Zn(II), respectively. An analysis of the temperature effect by the Gibbs equation showed that the sorption is exothermic and spontaneous. The mean free energy of sorption (obtained from D‐R equation) confirms that metal binding occurs through a chemical ion‐exchange mechanism. The kinetic profiles can be accurately fitted with the pseudo‐second order rate equation. Complementary analyses (using FTIR spectrometry and SEM‐EDX analysis) confirm that ion‐exchange is the main binding mechanism, though a contribution of surface complexation cannot be neglected.
Detection and measurement of radio frequency feedback for an on‐frequency repeater
Authors: Zeher Amar , Bilbault Jean‐Marie , Binczak Stéphane 
Published: January 2017

SummaryThe radio frequency feedback (RFF) occurs when the insulation is insufficient between the antennas of an on‐frequency repeater, increasing digital transmission errors. In addition, a strong RFF could compromise system stability of the on‐frequency repeater because of the growing power in the closed‐loop. Automatic gain control is widely used by the on‐frequency repeater to regulate the power, this solution being generally used with echo cancellation processes. Most of echo cancellation techniques are based on digital processing such as adaptive filters whose the effectiveness and the algorithm speed are depending on the signal frequency, the bandwidth and the closed‐loop parameters. This paper describes a solution of RFF estimation and detection regardless of the receiving signal modulation. By using the frequency scanning and the analysis of the power spectral density peaks in the system, this solution is reliable whatever are the values of the gain‐margin and the loop‐delay. Simulations and experimental implementation using field‐programmable gate array validate the solution. In addition, an example of applications is given in the context of the interference cancellation.
Is there an optimal length of psychological treatment for eating disorder pathology?
Authors: Bell Caroline , Waller Glenn , Shafran Roz , Delgadillo Jaime 
Published: January 2017

AbstractTreatment guidelines for eating disorders (ED) are unclear about the optimal length of psychological care. We aimed to investigate associations between treatment duration and changes in ED pathology. Data for 164 outpatients accessing psychological interventions for ED were analyzed using MANOVA. We tested associations between number of therapy sessions and pre‐post treatment changes in clinical outcomes (EDE‐Q global scores, binge eating, purging); adjusting for baseline measures, diagnoses, and treatment type. Secondary analyses included rapid response variables in the above outcomes by treatment session eight. Partial correlations between treatment duration and BMI changes (adjusting for intake BMI) were examined for anorexia nervosa cases. Treatment duration was not significantly associated with changes in ED outcomes after adjusting for rapid response. BMI change (weight regain) was not correlated with treatment duration in anorexia nervosa cases. Rapid response was associated with better EDE‐Q outcomes, but not with changes in binge eating or purging behaviors. ED outcomes are unrelated to treatment duration; rapid response is a useful prognostic indicator for treatment planning.
Endocannabinoid activation of CB1 receptors contributes to long‐lasting reversal of neuropathic pain by repetitive spinal cord stimulation
Authors: Sun L. , Tai L. , Qiu Q. , Mitchell R. , Fleetwood‐Walker S. , Joosten E.A. , Cheung C.W. 
Published: January 2017

AbstractBackgroundSpinal cord stimulation (SCS) has been shown to be effective in the management of certain neuropathic pain conditions, however, the underlying mechanisms are incompletely understood. In this study, we investigated repetitive SCS in a rodent neuropathic pain model, revealing long‐lasting and incremental attenuation of hyperalgesia and a mechanism of action involving endocannabinoids.MethodAnimals were implanted with monopolar electrodes at the time of partial sciatic nerve injury. Dorsal columns at spinal segments T12/13 were stimulated 3 days later (early SCS), and again at day 7 (late SCS) using low‐frequency parameters. Hypersensitivity to cutaneous mechanical stimuli was assessed using von Frey filaments. Pharmacological agents, selected to identify endocannabinoid and opioid involvement, were administered intraperitoneally, 10 min before SCS.ResultsEarly SCS caused partial reversal of mechanical hypersensitivity with corresponding changes in the biomarker of central sensitization, [phospho‐Tyr1472]‐GluN2B. The partial reversal of hyperalgesia by early SCS was amplified by co‐administration of LY 2183240, an inhibitor of endocannabinoid reuptake/breakdown. This amplification was inhibited by a CB1R antagonist, AM251, but not by a CB2R antagonist, AM630. Early SCS‐induced reversal of hyperalgesia was attenuated by naloxone, indicating a role for opioids. Late SCS resulted in an incremental level of reversal of hyperalgesia, which was inhibited by AM251, but not by CB2 or opioid receptor antagonists.ConclusionThe endocannabinoid system, and in particular the CB1R, plays a pivotal role in the long‐lasting and incremental reversal of hyperalgesia induced by repetitive SCS in a neuropathic pain model.SignificanceAlternative parameters for repetitive spinal cord stimulation (SCS) at 25/10 Hz elicit particularly long‐lasting and incremental reversal of hyperalgesia in a neuropathic pain model through a mechanism involving endocannabinoids.
Reduced laser‐evoked potential habituation detects abnormal central pain processing in painful radiculopathy patients
Authors: Hüllemann P. , von der Brelie C. , Manthey G. , Düsterhöft J. , Helmers A.K. , Synowitz M. , Baron R. 
Published: January 2017

AbstractBackgroundRepetitive painful laser stimuli lead to physiological laser‐evoked potential (LEP) habituation, measurable by a decrement of the N2/P2 amplitude. The time course of LEP‐habituation is reduced in the capsaicin model for peripheral and central sensitization and in patients with migraine and fibromyalgia. In the present investigation, we aimed to assess the time course of LEP‐habituation in a neuropathic pain syndrome, i.e. painful radiculopathy.MethodsAt the side of radiating pain, four blocks of 25 painful laser stimuli each were applied to the ventral thigh at the L3 dermatome in 27 patients with painful radiculopathy. Inclusion criteria were (1) at least one neurological finding of radiculopathy, (2) low back pain with radiation into the foot and (3) a positive one‐sided compression of the L5 and/or S1 root in the MRI. The time course of LEP‐habituation was compared to 20 healthy height and age matched controls. Signs of peripheral (heat hyperalgesia) and central sensitization (dynamic mechanical allodynia and hyperalgesia) at the affected L5 or S1 dermatome were assessed with quantitative sensory testing.ResultsPainful radiculopathy patients showed decreased LEP‐habituation compared to controls. Patients with signs of central sensitization showed a more prominent LEP‐habituation decrease within the radiculopathy patient group.ConclusionsLaser‐evoked potential habituation is reduced in painful radiculopathy patients, which indicates an abnormal central pain processing. Central sensitization seems to be a major contributor to abnormal LEP habituation. The LEP habituation paradigm might be useful as a clinical tool to assess central pain processing alterations in nociceptive and neuropathic pain conditions.SignificanceAbnormal central pain processing in neuropathic pain conditions may be revealed with the laser‐evoked potential habituation paradigm. In painful radiculopathy patients, LEP‐habituation is reduced compared to healthy controls.
A rapid electrochemical monitoring platform for sensitive determination of thiamethoxam based on β–cyclodextrin-graphene composite
Authors: Zhai XingChen , Zhang Hua , Zhang Min , Yang Xin , Gu Cheng , Zhou GuoPeng , Zhao HaiTian , Wang ZhenYu , Dong AiJun , Wang Jing 
Published: January 2017

Abstract

A rapid monitoring platform for sensitive voltammetric detection of thiamethoxam residues is reported in the present study. A β–cyclodextrin-reduced graphene oxide composite was used as a reinforcing material in electrochemical determination of thiamethoxam. Compared with bare glassy carbon electrodes, the reduction peak currents of thiamethoxam at reduced graphene oxide/glassy carbon electrode and β–cyclodextrin-reduced graphene oxide/glassy carbon electrode were increased by 70- and 124-fold, respectively. The experimental conditions influencing voltammetric determination of thiamethoxam, such as the amount of β–cyclodextrin-reduced graphene oxide, solution pH, temperature, and accumulation time, were optimized. The reduction mechanism and binding affinity of this material is also discussed. Under optimal conditions, the reduction peak currents increased linearly between 0.5 µM and 16 µM concentration of thiamethoxam. The limit of detection was 0.27 µM on the basis of a signal-to-noise ratio of 3. When the proposed method was applied to brown rice in a recovery test, the recoveries were between 92.20% and 113.75%. The results were in good concordance with the high-performance liquid chromatography method. The proposed method therefore provides a promising and effective platform for sensitive and rapid determination of thiamethoxam. Environ Toxicol Chem 2017;36:1991–1997. © 2017 SETAC
Atherectomy using a solid‐state laser at 355 nm wavelength
Authors: Herzog Amir , Oszkinis Grzegorz , Planer David , Ziaja Krzysztof , Kruszyna Łukasz , Stanisić Michał Goran , Ziaja Damian , Ishaaya Amiel A. , Kuczmik Wacław 
Published: January 2017

Peripheral arterial disease (PAD), caused by atherosclerotic processes, is allied with an increased risk of ischemic events, limb loss, and death. Recently, the use of a solid‐state laser at 355 nm within a hybrid catheter was suggested for that purpose. In this work, short nanosecond pulses of a solid‐state laser at 355 nm delivered through a hybrid catheter, composed of optical fibers and a blunt mechanical blade, are used to conduct a pre‐clinical study and two clinical cases. The pre‐clinical study consisted of an atherosclerotic calcified cadaveric leg and a porcine in vivo trial within the iliac artery, respectively. The clinical cases include chronic total occlusions with a calcified lesion. The occluded cadaveric leg is recanalized successfully and no evidence of thermal necrosis is indicated in the histopathology analysis of the porcine study. No arterial wall damage is demonstrated on the animals' treated arteries and no significant impact on blood count and biochemistry analysis is noted in the animal trial. Successful recanalization of the occluded arteries followed by balloon angioplasty is obtained in both clinical cases. Our work constitutes a proof of concept for using a solid‐state pulsed laser at 355 nm in atherectomy.
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3D bioprinting and itsin vivoapplications
Authors: Hong Nhayoung , Yang Gi‐Hoon , Lee JaeHwan , Kim GeunHyung 
Published: January 2017

AbstractThe purpose of 3D bioprinting technology is to design and create functional 3D tissues or organsin situforin vivoapplications. 3D cell‐printing, or additive biomanufacturing, allows the selection of biomaterials and cells (bioink), and the fabrication of cell‐laden structures in high resolution. 3D cell‐printed structures have also been used for applications such as research models, drug delivery and discovery, and toxicology. Recently, numerous attempts have been made to fabricate tissues and organs by using various 3D printing techniques. However, challenges such as vascularization are yet to be solved. This article reviews the most commonly used 3D cell‐printing techniques with their advantages and drawbacks. Furthermore, up‐to‐date achievements of 3D bioprinting inin vivoapplications are introduced, and prospects for the future of 3D cell‐printing technology are discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 444–459, 2018.
Ocular Effects of Sulfur Mustard and Therapeutic Approaches
Authors: Panahi Yunes , Rajaee Seyyed Mahdi , Sahebkar Amirhossein 
Published: January 2017

ABSTRACTSulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM‐induced ocular injuries, including preservative‐free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N‐acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino‐acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549–3560, 2017. © 2017 Wiley Periodicals, Inc.
Association of hematocrit with blood pressure and hypertension
Authors: Emamian Marzieh , Hasanian Seyed Mahdi , Tayefi Maryam , Bijari Moniba , Movahedian far Faeze , Shafiee Mojtaba , Avan Amir , Heidari‐Bakavoli Alireza , Moohebati Mohsen , Ebrahimi Mahmoud , Darroudi Sousan , Zamani Parvin , Azarpazhooh Mahmoud Reza , Nematy Mohsen , Safarian Mohammad , Ferns Gordon A. , Esmaeili Habibollah , Parizadeh Mohammad Reza , Ghayour‐Mobarhan Majid 
Published: January 2017

BackgroundHypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients.ObjectiveThe aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7‐year follow‐up.Materials and MethodsA total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects. Univariate and multivariate logistic regression analysis were performed to determine the association of biochemical and hematological parameters with HTN.ResultsSeveral biochemical parameters including fasting plasma glucose (FBG), serum high‐sensitivity C‐reactive protein (hs‐CRP), triglyceride (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and uric acid were increased in hypertensive participants. In contrast, serum high‐density lipoprotein cholesterol (HDL‐C) was lower in hypertensive individuals. Furthermore, we demonstrated that hematological parameters including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin (MCH) were higher in the hypertensive group compared to the control group. But mean corpuscular volume (MCV), and red cell distribution width (RDW), were decreased in the hypertensive group. Furthermore, our results strongly suggested that among these parameters, hematocrit was the independent risk factor for hypertension in the population.ConclusionWe demonstrated the association of altered biochemical and hematological factors with hypertension supporting the value of emerging markers for early prediction of high blood pressure in prone individuals.
Assessment of intracranial meningioma‐associated calcifications using susceptibility‐weighted MRI
Authors: Adams Lisa C. , Böker Sarah M. , Bender Yvonne Y. , Fallenberg Eva M. , Wagner Moritz , Buchert Ralph , Hamm Bernd , Makowski Marcus R. 
Published: January 2017

PurposeTo determine the diagnostic accuracy of susceptibility‐weighted MRI (SW‐MRI) for the detection of intracranial meningioma‐associated calcifications compared with standard MR sequences, using computed tomography (CT) as a reference standard.Materials and Methods354 patients, who had received both a CT and a 1.5 Tesla clinical brain MRI with SW‐MRI sequences between January 2014 and July 2016, were retrospectively evaluated and 316 patients were included. Calcification diameter was used to assess correlation between imaging modalities. Sensitivity and specificity as well as intra‐ and interobserver agreement were calculated for SW‐MRI and standard MRI sequences when compared with reference standard CT.ResultsFifty patients had positive findings for intracranial meningioma‐associated calcifications on CT scans. SW‐MRI reached a sensitivity of 94% (95% confidence interval [CI]: 83–99%) and a specificity of 95% (95% CI: 92–98%) for the detection of meningioma‐associated calcifications, while standard MRI yielded a sensitivity of 64% (95% CI: 49–77%) and a specificity of 94% (95% CI: 90–96%). Diameter measurements between SW‐MRI and CT showed a close correlation (R2 = 0.99; P < 0.001) with a slight overestimation of size, which, however, did not reach significance level (SW‐MRI: 8.2 mm ± 7.1; CT: 6.8 mm ± 6.4; P = 0.29). Compared with standard MRI, SW‐MRI showed a better interobserver agreement for size measurements of calcifications.ConclusionSW‐MRI enables a reliable detection of intracranial meningioma‐associated calcifications by using CT as a reference and offers a higher diagnostic accuracy than standard MRI.Level of Evidence: 3Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1177–1186.
Preoperative MRI of the breast and ipsilateral breast tumor recurrence: Long‐term follow up
Authors: Gervais Mai‐Kim , Maki Ellen , Schiller Dan E. , Crystal Pavel , McCready David R. 
Published: January 2017

BACKGROUND: Local recurrence after breast conserving surgery is reported in 5‐10% of cases. This study aims to determine if preoperative MRI is associated with reduced IBTR rates in the longer term and evaluate IBTR rates of a high risk (TN and Her‐2 positive) subgroup in those receiving MRI or not.METHODS: Between 1999 and 2005, patients with invasive breast cancer undergoing BCS and radiation were identified. Primary endpoint was IBTR rate.RESULTS: The cohort consisted of 470 cases: 27% underwent MRI and 73% did not. Median follow‐up was 97 months. Overall 10‐year IBTR rate was 3.6%. There was no significant difference in IBTR rate at 10 years between those receiving MRI or not (1.6% vs. 4.2% (P = 0.37). The TN and Her‐2 positive combined subgroup had a higher IBTR rate than all others (9.8% vs. 1.7%, P = 0.001). In the group without MRI, the IBTR rate of the high risk group was 11.8% compared to 1.8% in the remainder (P = 0.002).CONCLUSION: With 10‐year follow‐up, there was no significant difference in IBTR rate whether preoperative MRI is performed versus not. The high risk population showed an increased IBTR rate, this was more marked in those who did not receive MRI.
Does radiologic response correlate to pathologic response in patients undergoing neoadjuvant therapy for borderline resectable pancreatic malignancy?
Authors: Xia Brent T. , Fu Baojin , Wang Jiang , Kim Young , Ahmad S. Ameen , Dhar Vikrom K. , Levinsky Nick C. , Hanseman Dennis J. , Habib David A. , Wilson Gregory C. , Smith Milton , Olowokure Olugbenga O. , Kharofa Jordan , Al Humaidi Ali H. , Choe Kyuran A. , Abbott Daniel E. , Ahmad Syed A. 
Published: January 2017

BACKGROUND AND OBJECTIVESIn patients with borderline resectable pancreas cancers, clinicians frequently consider radiographic response as the primary driver of whether patients should be offered surgical intervention following neoadjuvant therapy (NT). We sought to determine any correlation between radiographic and pathologic response rates following NT.METHODSBetween 2005 and 2015, 38 patients at a tertiary care referral center underwent NT followed by pancreaticoduodenectomy for borderline resectable pancreas cancer. Radiographic response after the completion of NT and pathologic response after surgery were graded according to RECIST and Evans’ criteria, respectively.RESULTSPreoperatively, 50% of patients underwent chemotherapy alone and 50% underwent chemotherapy and chemoradiation. Radiographically, one patient demonstrated a complete radiologic response, 68.4% (n = 26) of patients had stable disease (SD), 26.3% (n = 10) demonstrated a partial response, and one patient had progressive. Among patients without radiographic response, 77.7% (n = 21) achieved a R0 resection. Of patients with SD on imaging, 26.9% (n = 7) had Evans grade IIB or greater pathologic response.CONCLUSIONSOur data indicate that approximately one‐fourth of patients who did not have a radiologic response had a grade IIB or greater pathologic response. In the absence of metastatic progression, lack of radiographic down‐staging following NT should not preclude surgery.