bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-year clinical outcome of patients with mildly reduced ejection fraction after acute myocardial infarction: insights from the prospective KAMIR-NIH Registry
Authors: Jeon Ho Sung , Lee Jun-Won , Moon Jin Sil , Kang Dae Ryong , Lee Jung-Hee , Youn Young Jin , Ahn Min-Soo , Ahn Sung Gyun , Yoo Byung-Su 
Published: September 2024

BackgroundLeft ventricular ejection fraction (LVEF) is a crucial prognostic indicator of acute myocardial infarction (AMI). However, there is a lack of studies on the clinical characteristics and prognosis of patients with mildly reduced ejection fraction (EF) after AMI.MethodsWe categorized 6,553 patients with AMI from the Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) between November 2011 and December 2015 into three groups based on their EF, as assessed by echocardiography during index hospitalization: reduced EF (LVEF ≤40%), mildly reduced EF (LVEF 41%–49%), and preserved EF (LVEF ≥50%). The primary outcome was all-cause death within 2 years. The secondary outcomes included myocardial infarction (MI), revascularization, and patient-oriented composite endpoint (POCE), which was defined as a composite of all-cause death, any MI, or revascularization.ResultsOf the total 6,553 patients, 884 (13.5%) were classified into the reduced EF group, 1,749 (26.7%) into the mildly reduced EF group, and 3,920 (59.8%) into the preserved EF group. Patients with mildly reduced EF exhibited intermediate mortality (reduced EF, 24.7%; mildly reduced EF, 8.3%; preserved EF, 4.6%; p &lt; 0.0001), MI (3.9% vs. 2.7% vs. 2.6%; p &lt; 0.0046), and POCE (33.0% vs. 15.6% vs. 12.4%; p &lt; 0.0001) rates, albeit closer to those of the preserved EF. After adjustment for demographics, risk factors, admission status, and discharge medications, patients with mildly reduced EF showed a lower risk of all-cause death than those with reduced EF (mildly reduced EF group as a reference: HR, 1.74; 95% CI, 1.40–2.18; p &lt; 0.001), but it did not differ significantly from those with preserved EF (HR, 0.94; 95% CI, 0.75–1.18; p = 0.999)ConclusionsOver a 2-year follow-up period, patients with AMI and mildly reduced EF demonstrated better prognoses than those with reduced EF, but did not differ significantly from those with preserved EF.
Clinical Trial Registrationcris.nih.go.kr, identifier: KCT−0000863.
Risk prediction of diabetic retinopathy based on visit-to-visit fasting blood glucose indices
Authors: Ju Ying , Guo Zhengyang , Ai Jiaqi , Yang Kai , Zhu Xiaoxuan , Shi Keai , Li Chunmei , Yu Tianyun , Xiao Yunfan , Su Binbin , Yan Jinxia , Li Ziyu , Lian Wei , Wang Zhenqin , Ding Shasha , Wang Yudie , Lu Fan , Cui Lele , Li Ming 
Published: September 2024

ObjectiveThe long-term glucose monitoring is essential to the risk assessment of diabetic retinopathy (DR), the aim of this study was to investigate the predictive ability of visit-to-visit fasting blood glucose (FBG) indices on the risk of DR.MethodsThis was a community-based, cohort study conducted from 2013 to 2021. DR was diagnosed by digital fundus photography. The FPG indices included FBG, var. Associations of each FBG indices and DR were estimated using multinomial logistic regression models adjusting for confounders, and discrimination was determined by area under the curve (AUC). Predictive utility of different models was compared by changes in AUC, integrated discrimination improvement (IDI), and net reclassification index (NRI).ResultsThis study analyzed 5054 participants, the mean age was 46.26 ± 11.44 years, and 2620 (51.84%) were women. After adjustment for confounders, the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for FBG, SD, CV, VIM, ARV, M-FBG, and cumulative FBG load were 1.62 (1.52—1.73), 2.74 (2.38—3.16), 1.78 (1.62—1.95), 1.11 (0.95—1.29), 1.72 (1.56—1.91), 2.15 (1.96—2.36), and 2.57 (2.31—2.85), respectively. The AUC of the model with separate cumulative FBG load and classical risk factors was 0.9135 (95%CI 0.8890—0.9380), and no substantive improvement in discrimination was achieved with the addition of other FBG indices once cumulative FBG load was in the model.ConclusionsCumulative FBG load is adequate for capturing the glucose-related DR risk, and the predictive utility of cumulative FBG load is not significantly improved by adding or replacing other FBG indices in the assessment of DR risk.
Connectivity of high-frequency bursts as SOZ localization biomarker
Authors: Pinto-Orellana Marco , Lopour Beth 
Published: September 2024

For patients with refractory epilepsy, the seizure onset zone (SOZ) plays an essential role in determining the specific regions of the brain that will be surgically resected. High-frequency oscillations (HFOs) and connectivity-based approaches have been identified among the potential biomarkers to localize the SOZ. However, there is no consensus on how connectivity between HFO events should be estimated, nor on its subject-specific short-term reliability. Therefore, we propose the channel-level connectivity dispersion (CLCD) as a metric to quantify the variability in synchronization between individual electrodes and to identify clusters of electrodes with abnormal synchronization, which we hypothesize to be associated with the SOZ. In addition, we developed a specialized filtering method that reduces oscillatory components caused by filtering broadband artifacts, such as sharp transients, spikes, or direct current shifts. Our connectivity estimates are therefore robust to the presence of these waveforms. To calculate our metric, we start by creating binary signals indicating the presence of high-frequency bursts in each channel, from which we calculate the pairwise connectivity between channels. Then, the CLCD is calculated by combining the connectivity matrices and measuring the variability in each electrode’s combined connectivity values. We test our method using two independent open-access datasets comprising intracranial electroencephalography signals from 89 to 15 patients with refractory epilepsy, respectively. Recordings in these datasets were sampled at approximately 1000 Hz, and our proposed CLCDs were estimated in the ripple band (80–200 Hz). Across all patients in the first dataset, the average ROC-AUC was 0.73, and the average Cohen’s d was 1.05, while in the second dataset, the average ROC-AUC was 0.78 and Cohen’s d was 1.07. On average, SOZ channels had lower CLCD values than non-SOZ channels. Furthermore, based on the second dataset, which includes surgical outcomes (Engel I-IV), our analysis suggested that higher CLCD interquartile (as a measure of CLCD distribution spread) is associated with favorable outcomes (Engel I). This suggests that CLCD could significantly assist in identifying SOZ clusters and, therefore, provide an additional tool in surgical planning for epilepsy patients.
Utilization of tissue-free minimal residual disease testing in colorectal cancer patients from Asia and Middle East
Authors: Jain Suyog , Dawood Shaheenah , Lavingia Viraj , Aderka Dan , Tahover Esther , Hsieh Yao-Yu , Temper Mark , Goldman Alesya , Akasheh Marwan AI. , Olsen Steve , Hsing Sandra San , Joshi Nisarg , Jen Hsiao-Yu 
Published: September 2024

IntroductionThe presence of minimal residual disease (MRD) after curative-intent surgery for early-stage cancers is associated with disease recurrence. Circulating tumour deoxyribonucleic acid (ctDNA) has emerged as a promising biomarker for MRD assessment in patients with colorectal cancer (CRC) who have undergone surgery or completed adjuvant therapy. MRD tests are already available for use in clinics; however, treatment decisions following MRD results obtained in routine practice are infrequently described. MethodsIn this observational study, we report on the real-world clinical use of Guardant Reveal, a validated tissue-free MRD assay, in the first 215 consecutive patients (279 samples) with CRC tested in Asia and the Middle East. ResultsOverall, 22% of patients had ctDNA detected in their first MRD test, and the frequency of ctDNA positivity increased with increasing tumour stage. 132 samples were tested with an earlier version of Guardant Reveal, one that assessed both genomic and epigenomic features. An updated version of the assay assesses only ctDNA methylation data and was used for the remaining 147 samples. In patients with stage II CRC, 71% of tests were ordered within 12 weeks after tumour resection, while for patients with stage III disease, 69% of tests were ordered after completion of all curative-intent treatment. DiscussionClinical cases utilizing tissue-free MRD assessment are described.
The effect of athletes' training satisfaction on competitive state anxiety—a chain-mediated effect based on psychological resilience and coping strategies
Authors: Yu Xiaomei , Yang Yang , He Bo 
Published: September 2024

IntroductionThis study aimed to investigate the relationship between athletes' training satisfaction and competitive state anxiety, by examining the mediating roles of psychological resilience and coping strategies. The findings provide a theoretical foundation and practical recommendations for enhancing athletes' training and mental health services.MethodsA questionnaire was utilized to assess training satisfaction, psychological resilience, coping strategies, and Competitive State Anxiety among a sample of 447 athletes. The data was examined through descriptive statistics, correlation analysis, and structural equation modeling, employing SPSS and the Process 3.5 plug-in.ResultsTraining satisfaction had a significant positive effect on psychological resilience (β = 0.726, p&lt;0.001), while training satisfaction (β = 0.178, p&lt;0.001) and psychological resilience (β = 1.138, p&lt;0.001) were found to have a significant positive effect on strategy. Additionally, training satisfaction, psychological resilience, and coping strategies all demonstrated a significant negative effect on competitive state anxiety (p&lt;0.001). Training satisfaction indirectly influenced competitive state anxiety through psychological resilience (indirect effect 1), coping strategies (indirect effect 2), and the combined mediating effect of psychological resilience and coping strategies (indirect effect 3), resulting in a total indirect effect of −0.385 [95% CI = (−0.433, −0.337)].DiscussionIn conclusion, enhancing athletes' training satisfaction can help reduce competitive state anxiety by improving psychological resilience and fostering positive coping mechanisms.
Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice
Authors: Yılmaz Dilara , Singh Amit , Wehrle Esther , Kuhn Gisela A. , Mathavan Neashan , Müller Ralph 
Published: September 2024

Frailty, a geriatric syndrome, is assessed using the frailty phenotype (FP) and frailty index (FI). While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgAD257A/D257A (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. Moreover, we also identified sex differences in these mice with females exhibiting slightly more physical decline compared to males. Frailty prevalence in PolgA mice at 40 weeks parallels that observed in naturally aging mice at 27 months and aging humans at 65–70 years. These findings contribute to understanding frailty onset and sex-specific patterns in this prematurely aging mouse model, emphasizing the significance of the PolgA mouse model in investigating aging and related disorders.
Antimicrobial and Phylogenomic Characterization of Bacillus cereus Group Strains Isolated from Different Food Sources in Italy
Authors: Farina Donatella , Bianco Angelica , Manzulli Viviana , Castellana Stefano , Parisi Antonio , Caruso Marta , Fraccalvieri Rosa , Serrecchia Luigina , Rondinone Valeria , Pace Lorenzo , Fasanella Antonio , Vetritto Valerio , Difato Laura Maria , Cipolletta Dora , Iatarola Michela , Galante Domenico 
Published: September 2024

Background: Bacillus cereus is a widespread environmental Gram-positive bacterium which is especially common in soil and dust. It produces two types of toxins that cause vomiting and diarrhea. At present, foodborne outbreaks due to Bacillus cereus group bacteria (especially Bacillus cereus sensu stricto) are rising, representing a serious problem in the agri-food supply chain. Methods: In this work, we analyzed 118 strains belonging to the Bacillus cereus group, isolated from several food sources, for which in vitro and in silico antibiotic resistance assessments were performed. Results: Many strains showed intermediate susceptibility to clindamycin, erythromycin, and tetracycline, suggesting an evolving acquisition of resistance against these antibiotics. Moreover, one strain showed intermediate resistance to meropenem, an antibiotic currently used to treat infections caused by Bacillus cereus. In addition to the phenotypic antimicrobial resistance profile, all strains were screened for the presence/absence of antimicrobial genes via whole-genome sequencing. There was inconsistency between the in vitro and in silico analyses, such as in the case of vancomycin, for which different isolates harbored resistance genes but, phenotypically, the same strains were sensitive. Conclusions: This would suggest that antibiotic resistance is a complex phenomenon due to a variety of genetic, epigenetic, and biochemical mechanisms.
The Diagnostic Value of qPCR Quantification of Paenibacillus larvae in Hive Debris and Adult Bees for Predicting the Onset of American Foulbrood
Authors: Papić Bojan , Žvokelj Lucija , Pislak Ocepek Metka , Hočevar Barbara , Kozar Monika , Rus Rene , Zajc Urška , Kušar Darja 
Published: September 2024

American foulbrood (AFB) is a serious infectious disease of honeybees (Apis mellifera) caused by Paenibacillus larvae. Increased P. larvae count in hive-related material is associated with an increased risk of AFB. Here, we quantified P. larvae cells in 106 adult bee and 97 hive debris samples using quantitative PCR (qPCR); 66/106 adult bee and 66/97 hive debris samples were collected simultaneously from the same bee colony (paired-sample design). The corresponding bee colonies were also examined for the presence of AFB clinical signs. A binary logistic regression model to distinguish between AFB-affected and unaffected honeybee colonies showed a strong diagnostic accuracy of both sample types for predicting the onset of AFB based on P. larvae counts determined by qPCR. The colonies with a P. larvae count greater than 4.5 log cells/adult bee or 7.3 log cells/mL hive debris had a 50% probability of being clinically affected and were categorized as high-risk. The AFB-unaffected colonies had significantly lower P. larvae counts than the AFB-affected colonies, but the latter did not differ significantly in P. larvae counts in relation to the severity of clinical signs. Both bee-related sample types had a high diagnostic value for predicting disease outcome based on P. larvae counts. These results improve the understanding of the relationship between P. larvae counts and AFB occurrence, which is essential for early detection of high-risk colonies.
NUTRITIONAL AND ENERGY VALUE OF MUSCLE TISSUE OF BULLS OF SPECIALIZED MEAT BREEDS IN PRIMORSKY KRAI
Authors: Косилов В.И. , Толочка В.В. , Миронова И.В. , Никонова Е.А. , Тимербулатова Р.Г. , Кадиров Н.Н. , Алексеев О.В. 
Published: September 2024

В статье приводятся результаты влияния генотипа бычков калмыцкой (I группа), абердин-ангусской (II группа) и герефордской пород (III группа) на показатели длиннейшей мышцы спины, такие как химический состав, энергетическая ценность и выход питательных веществ мышечной ткани туши. Бычки абердин-ангусской породы демонстрировали преимущество по пищевой и энергетической ценности мышечной ткани по сравнению с бычками калмыцкой и герефордской пород. Так, у абердин-ангуссов массовая доля сухого вещества в длиннейшей мышце спины была выше на 2,41 и 1,31% соответственно, экстрагируемого жира – на 1,22 и 0,89%, протеина – на 1,02 и 0,31%, концентрации энергии в 1 кг мышечной ткани – на 650,13 кДж (15,12%) и 399,76 кДж (8,79%), энергетической ценности всей мышечной ткани туши – на 106,30 мДж (29,40%) и 25,24 мДж (5,70%) по сравнению с калмыцкими и герефордскими аналогами. Минимальной пищевой и энергетической ценностью отличалась мышечная ткань бычков калмыцкой породы.
The article provides the results of the influence of the genotype of the bulls of Kalmyk (I group), Aberdeen Angus (group II) and Hereford breeds(group III) on the indicators of the longest back muscles, such as the chemical composition, energy value and nutrient yield of carcass muscle tissue. The bulls of the Aberdeen Angus breed showed the advantage in the nutritional and energy value of muscle tissue compared to Kalmyk and Hereford bulls. So, in Aberdeen Angusses, the mass fraction of the dry matter in the longest back muscle was higher by 2.41 and 1.31%, respectively, extractable fat – by 1.22 and 0.89%, protein – by 1.02 and 0.31%, energy concentrations in 1 kg of muscle tissue – by 650.13 kJ (15.12%) and 399.76 kJ (8.79%), energy value of the entire muscle tissue of the carcass – by 106.30 MJ (29.40%) and 25.24 MJ (5.70%) compared to Kalmyk and Hereford analogues. The muscle tissue of the Kalmyk bulls was characterized by minimal nutritional and energy value.
ECOLOGICAL AND GENETIC ADAPTATION STRATEGY OF SOME INVASIVE HYDROBIONT SPECIES
Authors: Слынько Е.Е. , Белкин Е.Н. , Климкин С.В. 
Published: September 2024

Проведены молекулярно-генетические и морфологические исследования рапаны Rapana venosa (Valenciennes, 1846) крымской акватории Чёрного моря с целью определения возможных причин инвазионного успеха этого моллюска. Молекулярно-генетический анализ проводили по гену COI в сравнении с данными по исходным и другим инвазионным популяциям. Полностью подтверждён необычайно низкий уровень генетической изменчивости рапаны в Чёрном море, однако в естественных популяциях Жёлтого, Восточно-Китайского и Японского морей её генетическая изменчивость весьма высокая. Показано, что большое значение в расселении рапаны имеет внутривидовое морфо-экологическое формообразование. У Rapana venosa крымской акватории Чёрного моря выявлены две морфо-экологические формы, связанные с особенностями развития пропорций раковины.
Molecular genetic and morphological studies of rapa whelk Rapana venosa (Valenciennes, 1846) of the Crimean Black Sea were carried out in order to determine the possible reasons for the invasive success of this mollusk. Molecular genetic analysis was carried out by COI gene in comparison with the data on initial and other invasive populations. The unusually low level of genetic variability of rapa whelk in the Black Sea is fully confirmed, however, in the natural populations of the Yellow, East China seas and Sea of Japan, its genetic variability is very high. It has been shown that intraspecific morpho-ecological formation is of great importance in the settlement of rapa whelk. Rapana venosa of the Crimean Black Sea has two morpho-ecological forms associated with the peculiarities of the development of shell proportions.
INCUBATION OF STURGEON ROE USING AN ELECTROSTATIC FIELD
Authors: Шмигель В.В. , Жолудева В.В. , Кутина А.Д. 
Published: September 2024

В данной статье на основе статистических методов проведено сравнение доли выхода личинок при инкубации икры в аппаратах Вейса без наложения электростатического поля и доли выхода личинок с наложением электростатического поля через систему электродов. На основе t-критерия Стьюдента проверена гипотеза о схожести (различии) результатов вылупления личинок стерляди в контрольной и экспериментальной группах. Результаты проверки позволили сделать вывод об эффективности наложения электростатического поля через систему электродов, что позволяет существенно снизить потери личинок.In this article, based on statistical methods, a comparison was made of the proportion of larval yield during incubation of roe in Weiss apparatus without application an electrostatic field and the proportion of larval yield with application an electrostatic field through a system of electrodes. Based on Student's t-test, the hypothesis of similarity (difference) in the results of hatching of sterlet larvae in the control and experimental groups was tested. The test results made it possible to conclude that the application of an electrostatic field through the electrode system is effective, which can significantly reduce the loss of larvae.
STUDI LITERATUR: MODEL PEMBELAJARAN DISCOVERY LEARNING DALAM MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PASCA PANDEMI COVID-19
Authors: Hasanah Laeny Siti 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar melalui model pembelajaran Discovery Learning sebagai inovasi pembelajaran yang dapat diterapkan oleh pendidik pasca pandemik Covid-19. Melalui kajian pustaka, metode “library research” analisis literatur digunakan dalam penelitian ini untuk melengkapi analisis terhadap berbagai sumber yang digunakan. Perumusan pertanyaan penelitian di awal penelitian dilanjutkan dengan penelaahan temuan penelitian terkait pelacakan jurnal terdahulu menggunakan artikel jurnal terindeks, buku, tesis, dan artikel online terkait penerapan Discovery Learning untuk mengumpulkan data kajian pustaka ini. Hasil studi literatur menunjukkan bahwa Pasca pandemi Covid-19 yang terjadi di Indonesia penerapan strategi belajar mengajar dengan model Discovery Learning cukup berhasil guna meningkatkan hasil belajar siswa. Dari studi literatur yang telah dilakukan terungkap bahwa Discovery Learning sebagai model pembelajaran pasca Covid-19 berkontribusi dalam meningkatkan hasil akhir pembelajaran dan proses pengajaran para siswa.
Interpolation Methods: A Study of Solving Annual Data into Quarterly and Monthly Data
Authors: Rotinsulu Tri Oldy , Radianto Elia 
Published: September 2024

This study aims to analyse the effect of Export Value (EKS_US$) and Exchange Rate (KURS_US$) on Gross Domestic Product (GDP) as a proxy for economic growth in Indonesia using multiple linear regression based on interpolated monthly data from annual data. In this paper, it is also explained about calculation examples, quarterly and monthly data interpolation methods using data from the Central Bureau of Statistics, namely Indonesia's Gross Domestic Product (GDP) for 2021-2022 at constant 2010 prices. Based on the calculation results, using multiple linear regression of monthly data for the 2018-2022 period, it shows that the estimated model has the best estimator, which is indicated by the variables used, passing the diagnostic test in the form of Multicollinearity, Heteroscedasticity, Autocorrelation, Normality, and Linearity tests. This indicates that the estimator value of the observed data is able to represent the random behaviour of the actual data. However, everything returns to the researcher, at which stage will be chosen is greatly influenced by various factors and considerations of the researcher. Thus, at certain stages and situations, it is very open to researchers to use data interpolation, especially on all data that has flow characteristics, such as GDP data, export values, exchange rates and others.
Keywords: Interpolated data; annual data; quarterly data; monthly data; diagnostic tests
Fully vertical AlN-on-SiC Schottky barrier diodes
Authors: Okumura Hironori , Imura Masataka , Miyazawa Fuga , Mainini Lorenzo 
Published: September 2024

Abstract
We demonstrated fully vertical Schottky barrier diodes (SBDs) that have a Si-doped AlN drift layer directly grown on an n-type 4H-SiC substrate by metal-organic CVD. The AlN SBD with a Ni anode showed a clear rectifying characteristic at 300–500 K and a rectification ratio of about 10–2. We found that the leakage current of the vertical AlN-on-SiC devices is affected by defects in the AlN drift layer and Schottky interface.