bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Iterative Framework for National Scenario Modelling for the Sustainable Development Goals (SDGs)
Authors: Allen Cameron , Metternicht Graciela , Wiedmann Thomas 
Published: January 2017

AbstractThe recently adopted global Sustainable Development Goals (SDGs) are intended to catalyse implementation of sustainable development. Their success or failure will rely heavily upon national implementation. However, the SDGs represent a broad, integrated and complex agenda that will be very challenging for countries to implement. Over the past decade, scenario analysis has emerged as a method that is particularly well suited to sustainable development and has seen a rapid expansion in national development planning practice. It will be an invaluable tool for governments in formulating their national SDG strategies. However, despite its increased application, there is limited guidance available on the use of scenario modelling in national development planning. By undertaking a review of the recent best practice literature as well as 22 contemporary scenario modelling case studies, this paper draws out lessons learned and proposes an iterative framework for ex ante scenario modelling to support national SDG planning. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Beta‐binomial model for meta‐analysis of odds ratios
Authors: Bakbergenuly Ilyas , Kulinskaya Elena 
Published: January 2017

In meta‐analysis of odds ratios (ORs), heterogeneity between the studies is usually modelled via the additive random effects model (REM). An alternative, multiplicative REM for ORsuses overdispersion. The multiplicative factor in this overdispersion model (ODM) can be interpreted as an intra‐class correlation (ICC) parameter. This model naturally arises when the probabilities of an event in one or both arms of a comparative study are themselves beta‐distributed, resulting in beta‐binomial distributions. We propose two new estimators of the ICC for meta‐analysis in this setting. One is based on the inverted Breslow‐Day test, and the other on the improved gamma approximation by Kulinskaya and Dollinger (2015, p. 26) to the distribution of Cochran'sQ. The performance of these and several other estimators of ICC on bias and coverage is studied by simulation. Additionally, the Mantel‐Haenszel approach to estimation of ORs is extended to the beta‐binomial model, and we study performance of various ICC estimators when used in the Mantel‐Haenszel or the inverse‐variance method to combine ORs in meta‐analysis. The results of the simulations show that the improved gamma‐based estimator of ICC is superior for small sample sizes, and the Breslow‐Day‐based estimator is the best for. The Mantel‐Haenszel‐based estimator of OR is very biased and is not recommended. The inverse‐variance approach is also somewhat biased for ORs≠1, but this bias is not very large in practical settings. Developed methods and R programs, provided in the Web Appendix, make the beta‐binomial model a feasible alternative to the standard REM for meta‐analysis of ORs. © 2017 The Authors.Statistics in MedicinePublished by John Wiley & Sons Ltd.
Understanding systematic and collaborative code changes by mining evolutionary trajectory patterns
Authors: Jiang Qingtao , Peng Xin , Wang Hai , Xing Zhenchang , Zhao Wenyun 
Published: January 2017

AbstractThe life cycle of a large‐scale software system can undergo many releases. Each release often involves hundreds or thousands of revisions committed by many developers over time. Many code changes are made in a systematic and collaborative way. However, such systematic and collaborative code changes are often undocumented and hidden in the evolution history of a software system. It is desirable to recover commonalities and associations among dispersed code changes in the evolutionary trajectory of a software system. In this paper, we present Summarizing Evolutionary Trajectory by Grouping and Aggregation (SETGA), an approach to summarizing historical commit records as trajectory patterns by grouping and aggregating relevant code changes committed over time. The SETGA extracts change operations from a series of commit records from version control systems. It then groups extracted change operations by their common properties from different dimensions such as change operation types, developers, and change locations. After that, SETGA aggregates relevant change operation groups by mining various associations among them. We implement SETGA and conduct an empirical study with 3 open‐source systems. We investigate underlying evolution rules and problems that can be revealed by the identified patterns and analyze the evolution of trajectory patterns in different periods. The results show that SETGA can identify various types of trajectory patterns that are useful for software evolution management and quality assurance.
Lynch Syndrome Limbo: Patient Understanding of Variants of Uncertain Significance
Authors: Solomon Ilana , Harrington Elizabeth , Hooker Gillian , Erby Lori , Axilbund Jennifer , Hampel Heather , Semotiuk Kara , Blanco Amie , Klein William M. P. , Giardiello Francis , Leonard Lori 
Published: January 2017

AbstractProviders and patients encounter challenges related to the management of Variants of Unknown Significance (VUS). A VUS introduces new counseling dilemmas for the understanding and psychosocial impact of uncertain genetic test results. This descriptive study uses Mishel's theory of uncertainty in illness to explore the experience of individuals who have received a VUS as part of the genetic testing process. Semi‐structured interviews were conducted with 27 adult individuals who received a VUS for Lynch syndrome mismatch repair genes between 2002 and 2013. The interviews were transcribed and analyzed. Most individuals recalled their result and perceived various types of uncertainty associated with their VUS. Half of the participants appraised their variant as a danger and implemented coping strategies to reduce the threat of developing cancer. Mobilizing strategies to reduce their risk included vigilant cancer surveillance, information seeking and notifying relatives. The majority of participants were unaware of the possibility of a VUS before receiving their result and expected reclassification over time. These results provide insight into the ways healthcare providers can support patients who receive VUS for Lynch syndrome. Findings also provide direction for future work that can further explicate the impact of receiving a VUS.
Steady and transient response of a laminar separation bubble to controlled disturbances
Authors: Yarusevych Serhiy , Kotsonis Marios 
Published: January 2017

The steady and transient response of a laminar separation bubble to flow disturbances is examined experimentally. Wind tunnel experiments are performed on a NACA 0012 aerofoil at a chord Reynolds number of 130 000 and angle of attack of $2^{\circ }$. Under the investigated conditions, a laminar separation bubble forms on the suction side of the aerofoil in the unperturbed flow. Periodic disturbances are introduced into the boundary layer just upstream of separation by means of a surface-mounted dielectric barrier discharge plasma actuator. Two-component, time-resolved particle image velocimetry measurements are performed to characterise both quasi-steady and transient response of the flow to periodic disturbances. The results show that the dynamics of the laminar separation bubble is dominated by the periodic shedding of shear layer vortices, forming upstream of the mean reattachment location due to the amplification of unstable flow disturbances. Introducing the controlled perturbations leads to significant changes in separation bubble topology and the characteristics of the dominant coherent structures, with the effect dependent on both amplitude and frequency of disturbances. Linear stability analysis demonstrates that the induced changes to the mean bubble topology affect the stability characteristics, reducing the maximum growth rate and the frequency of the most amplified disturbances by 35 % and 20 %, respectively, when the bubble length is reduced by up to 40 %. The observed changes in stability characteristics are shown to correlate with the attendant variations in the shape factor. The transient response of the bubble is associated with significant changes in the separation bubble dynamics, with significant differences observed between the relative duration (${\approx}45\,\%$) of the transients flow response associated with the introduction and removal of the controlled disturbances. A detailed analysis of the results offers new insight into the response of laminar separation bubbles to changes in the disturbance environment.
Serum and macular response to carotenoid-enriched egg supplementation in human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT)
Authors: Kelly David , Nolan John M. , Howard Alan N. , Stack Jim , Akuffo Kwadwo O. , Moran Rachel , Thurnham David I. , Dennison Jessica , Meagher Katherine A. , Beatty Stephen 
Published: January 2017

AbstractThe macular carotenoids lutein (L), zeaxanthin (Z) andmeso-zeaxanthin (MZ) accumulate at the macula, where they are collectively referred to as macular pigment (MP). Augmentation of this pigment, typically achieved through diet and supplementation, enhances visual function and protects against progression of age-related macular degeneration. However, it is known that eggs are a rich dietary source of L and Z, in a highly bioavailable matrix. In this single-blind placebo-controlled study, L- and MZ-enriched eggs and control non-enriched eggs were fed to human subjects (mean age 41 and 35 years, respectively) over an 8-week period, and outcome measures included MP, visual function and serum concentrations of carotenoids and cholesterol. Serum carotenoid concentrations increased significantly in control and enriched egg groups, but to a significantly greater extent in the enriched egg group (P<0·001 for L, Z and MZ). There was no significant increase in MP in either study group post intervention, and we saw no significant improvement in visual performance in either group. Total cholesterol increased significantly in each group, but it did not exceed the upper limit of the normative range (6·5 mmol/l). Therefore, carotenoid-enriched eggs may represent an effective dietary source of L, Z and MZ, reflected in significantly raised serum concentrations of these carotenoids, and consequentially improved bioavailability for capture by target tissues. However, benefits in terms of MP augmentation and /or improved visual performance were not realised over the 8-week study period, and a study of greater duration will be required to address these questions.
Is cestode infection intensity associated with decreased body condition in the Eurasian woodcockScolopax rusticola?
Authors: Sánchez-García C. , Harris E. , Deacon A.C. , Bray R. , Hoodless A.N. 
Published: January 2017

AbstractThe Eurasian woodcockScolopax rusticolais a widespread woodland specialist and a widely harvested quarry species throughout its European wintering areas, including Britain. Woodcock are prone to cestodiasis, but prevalence levels and possible effects on body condition remain under-studied. We studied the prevalence, abundance and intensity of cestodiasis in 161 woodcock harvested in four British regions in December and January during two consecutive winters (2013/14 and 2014/15). Cestodiasis prevalence was 90%, and there was no difference in prevalence between birds harvested in Cornwall, Wessex, East Anglia and Scotland. High prevalence levels were explained by the fact that earthworms (Lumbricidae) are intermediate hosts for some cestode species and also the most important dietary component of woodcock. The distribution of cestodiasis in woodcock was aggregated, such that when using the total length of cestodes per sample to measure abundance, 65% of the birds had less than 80 cm. Cestodiasis abundance varied between sexes across regions but the intensity was not affected by region, sex, age or their interactions. The intensity of cestodiasis was positively correlated with fresh weight and pectoral mass, while no significant correlation was found with the abdominal fat pad. Our results suggest that, despite high prevalence levels and intensity of cestodiasis in woodcock, host body condition is not significantly affected and hence it is unlikely that cestodiasis has a major effect on woodcock population dynamics.
Cost analysis of osteoradionecrosis
Authors: Park L , Lilic N , Addison B , Patel R 
Published: January 2017

AbstractObjective:Osteoradionecrosis is a significant complication of head and neck cancer treatment, and its most severe form (grade III) necessitates radical surgery. This study aimed to compare the cost of free-flap reconstructive surgery for grade III osteoradionecrosis and similar non-osteoradionecrosis cases in order to assess the cost burden of osteoradionecrosis treatment.Methods:All patients who underwent free-flap reconstructive surgery for osteoradionecrosis between July 2004 and July 2010 at Auckland City Hospital (19 patients) were identified, and relevant data were collected retrospectively. These patients were matched in terms of age and sex with patients who underwent free-flap reconstructive surgery.Results:The treatment cost was 44 per cent higher in osteoradionecrosis patients when compared to non-osteoradionecrosis patients.Conclusion:The significant financial burden on the health system, and the growing evidence for the effectiveness of pentoxifylline, tocopherol and clodronate, should prompt us to explore this alternative treatment further.
Clinical features and management ofPlasmodium knowlesiinfections in humans
Authors: DANESHVAR CYRUS , WILLIAM TIMOTHY , DAVIS TIMOTHY M. E. 
Published: January 2017

SUMMARYPlasmodium knowlesiis a simian malaria of primarily the macaque species of South East Asia. While it was known that human infections could be induced during the years of malariotherapy, naturally occurringP. knowlesihuman infections were thought to be rare. However, in 2004, knowlesi infections became recognized as an important infection amongst human populations in Sarawak, Malaysian Borneo. Since then, it has become recognized as a disease affecting people living and visiting endemic areas across South East Asia. Over the last 12 years, clinical studies have improved our understanding of this potentially fatal disease. In this review article the current literature is reviewed to give a comprehensive description of the disease and treatment.
Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data
Authors: Madsen I. E. H. , Nyberg S. T. , Magnusson Hanson L. L. , Ferrie J. E. , Ahola K. , Alfredsson L. , Batty G. D. , Bjorner J. B. , Borritz M. , Burr H. , Chastang J.-F. , de Graaf R. , Dragano N. , Hamer M. , Jokela M. , Knutsson A. , Koskenvuo M. , Koskinen A. , Leineweber C. , Niedhammer I. , Nielsen M. L. , Nordin M. , Oksanen T. , Pejtersen J. H. , Pentti J. , Plaisier I. , Salo P. , Singh-Manoux A. , Suominen S. , ten Have M. , Theorell T. , Toppinen-Tanner S. , Vahtera J. , Väänänen A. , Westerholm P. J. M. , Westerlund H. , Fransson E. I. , Heikkilä K. , Virtanen M. , Rugulies R. , Kivimäki M. ,   for the IPD-Work Consortium
Published: January 2017

BackgroundAdverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.MethodWe identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.ResultsWe included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47–2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04–1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94–1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81–1.32).ConclusionsJob strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.
ʿAbd Allāh ibn al-Zubayr and the Mahdī: Between propaganda and historical memory in the Second Civil War
Authors: Shaddel Mehdy 
Published: January 2017

AbstractThe subject of the present paper is a prophetic tradition found in some compendia of eschatologicalaḥādīthwhich has received considerable scholarly attention since Wilferd Madelung dedicated an article to it in 1981. Whereas Madelung shares the opinion of earlier scholars that only some of the incidents “prophesied” by this tradition are historical, this study aims to show that it is a whollyex post factocomposition which, in its various strata, remarkably captures episodes from the Zubayrid war of propaganda against their rivals as well as their later attempts to redeem the memory of their lost cause as a just one. The discussion closes by producing a highly singular Syrian tradition most certainly put into circulation with the intent of countering these Zubayrid propaganda efforts.
All in it Together? Community Food Aid in a Multi-Ethnic Context
Authors: POWER MADELEINE , DOHERTY BOB , SMALL NEIL , TEASDALE SIMON , PICKETT KATE E. 
Published: January 2017

AbstractThis paper derives from a study of community food aid in a multi-ethnic, multi-faith city in the North of England. The paper begins to make sense of the diversity of types of food insecurity assistance, examines the potential exclusion of certain groups from receipt of food aid, and explores the relationship between food aid providers and the state. Faith-based food aid is common in the case study area, particularly among food bank provision to the most ‘destitute’ clients. While food aid is adopting service responsibilities previously borne by the state, this does not imply an extension of the ‘shadow state’. Rather, it appears reflective of a pre-welfare state system of food distribution, supported by religious institutions and individual/business philanthropy, but adapted to be consistent with elements of the ‘Big Society’ narrative. Most faith-based providers are Christian. There is little Muslim provision of (or utilisation of) food aid, despite the local demographic context. This raises concerns as to the unintentional exclusion of ethnic and religious groups, which we discuss in the concluding sections.
INFLUENCE OF HEALTH TECHNOLOGY ASSESSMENT AND ITS MEASUREMENT
Authors: Hailey David , Werkö Sophie , Rosén Måns , Macpherson Karen , Myles Susan , Gallegos Rivero Verónica , Hipólito-Olivares Cecilia , Sihvo Sinikka , Pwu Jasmine , Yang Wen-Wen , Chen Yong-Chen , Perez Galán Ana , Aleman Alicia , Villamil Elena 
Published: January 2017

Objectives: The aim of this study was to obtain information on methods used to measure health technology assessment (HTA) influence, decisions that were influenced, and outcomes linked to HTA.Methods: Electronic databases were used to locate studies in which HTA influence had been demonstrated. Inclusion criteria were studies that reliably reported consideration by decision makers of HTA findings; comparative studies of technology use before and after HTA; and details of changes in policy, health outcomes, or research that could be credibly linked to an HTA.Results: Fifty-one studies were selected for review. Settings were national (24), regional (12), both national and regional (3) hospitals (9), and multinational (3). The most common approach to appraisal of influence was review of policy or administrative decisions following HTA recommendations (51 percent). Eighteen studies (35 percent) reported interview or survey findings, thirteen (26 percent) reviewed administrative data, and six considered the influence of primary studies. Of 142 decisions informed by HTA, the most common types were on routine clinical practice (67 percent of studies), coverage (63 percent), and program operation (37 percent). The most frequent indications of HTA influence were on decisions related to resource allocation (59 percent), change in practice pattern (31 percent), and incorporation of HTA details in reference material (18 percent). Few publications assessed the contribution of HTA to changing patient outcomes.Conclusions: The literature on HTA influence remains limited, with little on longer term effects on practice and outcomes. The reviewed publications indicated how HTA is being used in different settings and approaches to measuring its influence that might be more widely applied, such as surveys and monitoring administrative data.
Framing justice in REDD+ governance: centring transparency, equity and legitimacy in readiness implementation in West Africa
Authors: ISYAKU USMAN , ARHIN ALBERT A. , ASIYANBI ADENIYI P. 
Published: January 2017

SUMMARYThis paper investigates the dimensions of justice in Reducing Emissions from Deforestation and forest Degradation plus enhancement of forest carbon stock (REDD+) in West Africa. By paying explicit attention to transparency, equity and legitimacy (TEL) in Nigeria and Ghana, the paper examines justice considerations in REDD+ implementation with a focus on tenure. We draw on analysis of policy documents and interviews with stakeholders in both countries. Our results show that commitment to the pursuit of justice in both cases is limited when examined through the elements of TEL. Efforts to recognize the tenure rights of indigenous peoples, effective representation in decision making and transparent disclosure of information to all stakeholders were limited in Ghana by the tacit evasion of tenure ambiguities, especially in the migrant-dominated REDD+ pilot areas. In Nigeria, such limits were shown in a similar evasion and in the strategic orchestration of tenure complexities evident in the changing local forest access under a protectionist regime. We argue that explicit attention to TEL as mediating dimensions of the normative elements of justice provides important insights into how environmental policy instruments such as REDD+ might both enable and disable justice for local people living around project sites.