bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dilemma of family education for hearing‐impaired children in China: Responsibility or evasion?
Authors: Xiong Xiaomeng , Li Yan 
Published: October 2024

AbstractDue to the difficulty in identifying and monitoring factors that cause hearing impairment during pregnancy, large numbers of new hearing‐impaired children are born every year. Children's hearing impairment can have an impact on all aspects of the family. Family education, as an important element of family function, plays a key role in the growth and development of hearing‐impaired children and in improving the interaction between hearing‐impaired children and their parents. Based on a qualitative study in central China, this article examines the current situation and dilemmas of family education for hearing‐impaired children. Results show that families of hearing‐impaired children generally have a tendency to avoid family education responsibilities, as demonstrated by the lack of family roles, low participation in specific family education, absence of communication and care functions and a laissez‐faire approach to bringing up their children. This evasive tendency cannot simply be attributed to parental irresponsibility; rather, it is the result of a combination of four factors and is closely related to insufficient social support. In the short term, a two‐pronged approach is needed: strengthening the government's responsibility and rendering assistance for families with hearing‐impaired children on the one hand, and establishing reliable links between home and school to provide professional support on the other. In the long run, it is necessary to build up a social support mechanism with social work intervention. This paper puts forward the need for collaboration among multiple parties and a family‐centred assistance model to promote a shift from the tendency towards evasion to active assumption of family responsibility.
Comprehensive Proteomic Analysis of Dysferlinopathy Unveiling Molecular Mechanisms and Biomarkers Linked to Pathological Progression
Authors: Wang Di , Liu Xin‐yi , He Qi‐Fang , Zheng Fu‐ze , Chen Long , Zheng Ying , Zeng Ming‐hui , Lin Yu‐hua , Lin Xin , Chen Hai‐zhu , Lin Min‐ting , Wang Ning , Wang Zhi‐qiang , Lin Feng 
Published: October 2024

ABSTRACTAimsPrevious proteomics studies in dysferlinopathy muscle have been limited in scope, often utilizing 2D‐electrophoresis and yielding only a small number of differential expression calls. To address this gap, this study aimed to employ high‐resolution proteomics to explore the proteomic landscapes of dysferlinopathy and analyze the correlation between muscle pathological changes and alterations in protein expression in muscle biopsies.MethodsWe conducted a comprehensive approach to investigate the proteomic profile and disease‐associated changes in the muscle tissue proteome from 15 patients with dysferlinopathy, exhibiting varying degrees of dystrophic pathology, alongside age‐matched controls. Our methodology encompasses tandem mass tag (TMT)‐labeled liquid chromatography‐mass spectrometry (LC–MS/MS)‐based proteomics, protein–protein interaction (PPI) network analysis, weighted gene co‐expression network analysis, and differential expression analysis. Subsequently, we examined the correlation between the expression of key proteins and the clinical characteristics of the patients to identify pathogenic targets associated with DYSF mutations in dysferlinopathy.ResultsA total of 1600 differentially expressed proteins were identified, with 1321 showing high expression levels and 279 expressed at lower levels. Our investigation yields a molecular profile delineating the altered protein networks in dysferlinopathy‐afflicted skeletal muscle, uncovering dysregulation across numerous cellular pathways and molecular processes, including mRNA metabolic processes, regulated exocytosis, immune response, muscle system processes, energy metabolic processes, and calcium transmembrane transport. Moreover, we observe significant associations between the protein expression of ANXA1, ANXA2, ANXA4, ANXA5, LMNA, PYGM, and the extent of histopathologic changes in muscle biopsies from patients with dysferlinopathy, validated through immunoblotting and immunofluorescence assays.ConclusionsThrough the aggregation of expression data from dysferlinopathy‐impacted muscles exhibiting a range of pathological alterations, we identified multiple key proteins associated with the dystrophic pathology of patients with dysferlinopathy. These findings provide novel insights into the pathogenesis of dysferlinopathy and propose promising targets for future therapeutic endeavors.
Pharmacokinetic comparison of subcutaneously administered CT‐P13 (biosimilar of infliximab) via autoinjector and pre‐filled syringe in healthy participants
Authors: Park Ye Chan , Kim Jae Hoon , Kim Sung Hyun , Lee Ju Hyun , Hong Jang Hee , Jung Jin‐Gyu , Sunwoo Jung 
Published: October 2024

AbstractCT‐P13, a biosimilar of infliximab, is used to treat inflammatory diseases that arise from immune system complications, resulting in excessive and persistent inflammation. The subcutaneous (SC) formulation of CT‐P13 overcomes the drawback of prolonged administration associated with the intravenous (IV) infliximab biosimilar, necessitating autoinjector (AI) administration. This randomized, open‐label, two‐arm, parallel‐group, single‐dose clinical pharmacology study aimed to evaluate the pharmacokinetics (PK) and safety of CT‐P13 SC administration via AI compared with the existing pre‐filled syringe (PFS) method. A total of 147 healthy participants were randomized into two groups, of which 139 completed the study. Blood samples were collected from before CT‐P13 SC administration to 2016 h after the start of the administration. Serum concentrations were analyzed using the Meso Scale Discovery electrochemiluminescence method. Geometric mean ratios (90% confidence interval) of the AUCinf (areas under the concentration–time curve from zero to infinity) and Cmax (The maximum serum concentration) for CT‐P13 SC AI versus CT‐P13 SC PFS groups, were 94.15% (85.02%–104.26%), 92.48% (84.66%–101.01%), respectively. CT‐P13 SC AI and CT‐P13 SC PFS achieved comparable PK because the 90% CI was within the predefined equivalence margin. At the end of the study, immunogenicity results revealed that 70 (97.22%) and 73 (98.65%) participants tested positive for anti‐drug antibody (ADA) in the CT‐P13 SC AI and CT‐P13 SC PFS groups, respectively. They were tested positive for neutralizing antibodies. No other significant safety differences were observed between the treatment groups. In conclusion, both administrations demonstrated PK equivalence and were both safe and well‐tolerated.
Pharmacokinetic model‐guided enoxaparin dosing in the Neonatal ICU: Retrospective cohort study to plan for prospective feasibility trial
Authors: Bunn Haden , Schentag Catherine , Brandão Leonardo R. , Ivaturi Vijay , Lewis Tamorah 
Published: October 2024

AbstractTraditional milligram per kilogram (mg/kg) dosing of enoxaparin in neonates frequently fails to achieve target anti‐Xa levels promptly, necessitating repeated laboratory monitoring and dose adjustments. This study investigated whether a personalized dosing strategy based on predicted individual clearance and volume of distribution could improve outcomes, comparing standard‐of‐care (SOC) mg/kg dosing to pharmacokinetic (PK) model‐informed precision dosing (MIPD). A retrospective analysis was conducted on hospitalized neonates treated with enoxaparin at less than 44 weeks postmenstrual age from 2019 to 2022. Data on demographics, drug dosing, PK model covariates, and clinical outcomes were extracted from electronic health records and analyzed using the Pumas‐AI Lyv dosing tool. The primary focus was on comparing the initial SOC dose to the MIPD‐recommended dose. The secondary outcome measured was the time required to achieve therapeutic anti‐Xa levels. The study included 168 neonates with a median postnatal age of 15 days (range 1–149) and a median dosing weight of 3.1 kg (range: 0.82–5.2). MIPD‐recommended initial doses were 20%–60% higher than SOC doses in 32% of the cases and over 60% higher in 11% of cases. Neonates who received SOC doses that were much lower than the MIPD recommendation showed the longest delays in reaching therapeutic anti‐Xa levels. The results indicate that PK model‐informed of enoxaparin dosing leads to higher initial dosages than SOC in neonates, potentially reducing the time to therapeutic anti‐Xa levels. These findings are being utilized to define dosing limits for a prospective trial of MIPD in neonatal intensive care settings.
Problems when diagnosing cutaneous leishmaniasis: a retrospective study analyzing clinical, histopathological and immunohistochemical features
Authors: Guillet Carole , Stillhard Andrea , Welti Michèle , Hauser Xenia , Kempf Werner , Riera Cristina , Grimm Felix , Schmid‐Grendelmeier Peter , Kolm Isabel 
Published: October 2024

SummaryBackgroundCutaneous leishmaniasis (CL) incidence in Switzerland is rising due to factors like migration and globalization. The aim of this work was to investigate CL frequency in Switzerland and identify clinical and histopathological difficulties in diagnosing CL in a non‐endemic country.Patients and MethodsThis retrospective study evaluated the clinical and histopathological characteristics of all CL cases from two dermatopathology laboratories between 2000 and 2022. Skin biopsies were histopathologically reviewed using HE, Giemsa, and immunohistochemical stain for CD1a and a specific Leishmania antibody (LA). PCR to detect Leishmania DNA was performed if sufficient tissue was available.Results42 cases (27 m, 15 f) were included. The correct clinical diagnosis of CL was only made in 15 (35.7%) cases. In seven (16.6%) cases, CL was missed in the initial histopathologic evaluation. Two main histopathological patterns were observed: granulomatous and pseudolymphomatous. Immunohistochemical staining with CD1a and Leishmania‐specific antibody was positive in 91% and 80% of cases, respectively. Leishmania PCR was positive in 25 of 26 cases, mainly detecting Old World species.ConclusionsCL is rare in Switzerland and often misdiagnosed clinically and histopathologically. CD1a and specific Leishmania antibody stainings are useful. CL should be considered in non‐healing ulcers, even without a history of travel to endemic areas.
Serum levels of the incretin‐like peptide 26RFa are diminished in women living with obesity and diabetes and restored after sleeve gastrectomy: Results from the prospective pilot RFa‐Ba‐S study
Authors: Khiar Hind , Lévêque Emilie , Lopez Antoine‐Guy , Moreau‐Grangé Lucile , Richard Lucile , Brunel Valéry , Perdrix Anne , Takhlidjt Saloua , Devère Mélodie , Tavolacci Marie‐Pierre , Houivet Estelle , Huet Emmanuel , Degrimaudet Benoît , Travers Carole , Leprince Jérôme , Picot Marie , Chartrel Nicolas , Prévost Gaëtan 
Published: October 2024

AbstractAimTo investigate the evolution of the incretin‐like peptide 26RFa in a prospective cohort of women living with obesity with or without type 2 diabetes (T2D) before and after sleeve gastrectomy (SG).MethodsIn this study, a total of 61 women were divided into three groups: women living with severe obesity without T2D (WlwOB group), women living with severe obesity and T2D (WlwOB‐T2D group) and lean healthy volunteers (control group). Serum 26RFa concentrations were measured using a 26RFa enzyme‐linked immunosorbent assay developed specifically for this study during meal tests before SG, and 30 and 180 days after SG.ResultsAt baseline, serum 26RFa levels were reduced in the WlwOB (P < .05) and WlwOB‐T2D (P < .01) groups compared with controls. In the WlwOB‐T2D group, fasting 26RFa levels were found to increase throughout the entire follow‐up period up to 6 months after the SG (P < .001). During the meal tests, serum 26RFa levels increased, especially in the WlwOB‐T2D group at baseline. At the end of the follow‐up, the profile of 26RFa concentrations obtained during the meal test in patients with severe obesity and T2D was similar to that of the controls.ConclusionsThis prospective clinical study provides the first evidence that circulating 26RFa is altered mainly in WlwOB‐T2D, and that these defects are partially reversed after SG.
Association of hypertension and long‐term blood pressure changes with new‐onset diabetes in the elderly: A 10‐year cohort study
Authors: Li Shanshan , Yang Boyi , Shang Shasha , Jiang Wei 
Published: October 2024

AbstractAimTo explore the correlation between new‐onset diabetes (NOD), hypertension and blood pressure management among elderly individuals in China.Materials and MethodsA cohort analysis involved 1380 participants aged 60 years or older, initially free of diabetes in 2008, from the Chinese Longitudinal Healthy Longevity Survey. Follow‐up assessments occurred every 2‐3 years. The relationship between hypertension, blood pressure changes and NOD was analysed using multivariable‐adjusted Cox regression.ResultsBy 2018, 102 participants developed diabetes, while 1278 remained without diabetes. The cumulative diabetes prevalence increased from 3.1% at 3 years to 7.4% at 10 years. Hypertension prevalence increased from 20.9% at baseline to 41.0% at 10 years, with higher rates in those diagnosed with diabetes during follow‐up. Multivariate analysis identified age, gender, baseline hypertension and systolic blood pressure (SBP) as independent predictors of NOD. Hypertension combined with overweight/obesity significantly increased the risk of NOD (hazard ratio [HR] 2.837; 95% confidence interval [CI], 1.680‐4.792). We evaluated participants' blood pressure management levels in 2008 and 2011, then tracked the onset of diabetes from 2011 to 2018. Compared with participants with an average SBP below 120 mmHg in 2008 and 2011, those with SBP of 140 mmHg or higher had an 8‐fold higher risk of developing NOD (adjusted HR8.492, 95% CI 2.048‐35.217, P = .003), the highest risk group. Participants with SBP of 130‐139.9 mmHg also had a significantly increased risk (adjusted HR 5.065, 95% CI 1.186‐21.633, P = .029), while those with SBP of 120‐129.9 mmHg showed no significant difference (HR 2.730, 95% CI 0.597‐12.481, P = .195). Consistently high SBP (≥ 130 mmHg) further increased NOD risk (adjusted HR 3.464, 95% CI 1.464‐8.196, P = .005).ConclusionsSignificant predictors of NOD included age, gender, baseline hypertension and blood pressure management. Maintaining SBP consistently below 130 mmHg may be an effective strategy to reduce the incidence of NOD in the general elderly population.
Employer cooperation, productivity and wages: new evidence from inter‐firm formal network agreements
Authors: Devicienti Francesco , Grinza Elena , Manello Alessandro , Vannoni Davide 
Published: October 2024

AbstractUsing uniquely rich administrative matched employer–employee data for Italy from 2008 to 2018, we investigate the impact of firms' formal network agreements (FNAs) on firm performance and employee wages. We find an overall significant and economically relevant positive effect of FNAs on various measures of firm performance, but there are no tangible benefits for the workers, and wages decrease slightly, on average. There is, however, marked heterogeneity in the impact on both firms and workers. Estimated rent‐sharing equations, as well as other tests that exploit unionization data, suggest that the negative effects on wages can be explained by a decrease in workers' bargaining power following the introduction of FNAs.
Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes
Authors: van der Stouwe Jan Gerrit , Godly Konstantin , Kraler Simon , Godly Julia , Matter Christian M. , Wenzl Florian A. , von Eckardstein Arnold , Räber Lorenz , Mach François , Obeid Slayman , Templin Christian , Lüscher Thomas F. , Niederseer David ,   the SPUM‐ACS investigators
Published: October 2024

AbstractBackgroundInflammatory processes can trigger acute coronary syndromes (ACS) which may increase core body temperature (BT), a widely available low‐cost marker of systemic inflammation. Herein, we aimed to delineate baseline characteristics of ST‐segment elevation myocardial infarction (STEMI) and non‐ST‐segment elevation ACS (NSTE‐ACS) patients stratified by initial BT and to assess its predictive utility towards major adverse cardiovascular events (MACE) after the index ACS.MethodsFrom 2012 until 2017, a total of 1044 ACS patients, 517 with STEMI and 527 with NSTE‐ACS, were prospectively recruited at the University Hospital Zurich. BT was measured by digital tympanic thermometer along with high‐sensitivity C‐reactive protein (hs‐CRP) and cardiac troponin‐T (hs‐cTnT) levels prior to coronary angiography. Patients were stratified according to initial BT and uni‐ and multivariable regression models were fit to assess associations of BT with future MACE risk.ResultsAmong patients with STEMI, BT was not predictive of 1‐year MACE, but a U‐shaped relationship between BT and MACE risk was noted in those with NSTE‐ACS (p = .029), translating into a 2.4‐fold (HR, 2.44, 95% CI, 1.16–5.16) increased 1‐year MACE risk in those with BT >36.8°C (reference: 36.6–36.8°C). Results remained robust in multivariable‐adjusted analyses accounting for sex, age, diabetes, renal function and hs‐cTnT. However, when introducing hs‐CRP, the BT‐MACE association did not prevail.ConclusionsIn prospectively recruited patients with ACS, initial BT shows a U‐shaped relationship with 1‐year MACE risk among those with NSTE‐ACS, but not in those with STEMI. BT is a broadly available low‐cost marker to identify ACS patients with high inflammatory burden, at high risk for recurrent ischaemic events, and thus potentially suitable for an anti‐inflammatory intervention.RegistrationClinicalTrials.gov Identifier: NCT01000701.
The wonder of being: Varieties of rationalism and its critique
Authors: Kern Andrea 
Published: October 2024

AbstractIn his book The Culmination, Pippin leaves no doubt that he still thinks that German Idealism has achieved a level of understanding and radicality that makes its proponents the best conversational partners to develop an understanding of what philosophy is about. It is the question of the very possibility of understanding that comes to be at the center of their writings and informs every page. Yet this radicality is now seen in a different light. It is now conceived as a culmination, not of an understanding that comes to itself but of a misunderstanding that informs, unavoidably, Western philosophical tradition as a whole. The resources for the idea that there is something fundamentally wrong in the conception of what it is to be a being that is able to know anything at all Pippin finds most vividly and forcefully articulated in Heidegger. I will argue that there is something profoundly true about Pippin's idea that, at the bottom of any knowledge we have of ourselves and the world, there is something that Heidegger calls Stimmung, which is essentially non‐discursive. However, I will argue that to defend the latter thought, one has to read Heidegger's notion of Stimmung in a more radical way than Pippin seems to be willing to.
Impact of elevated lipoprotein(a) levels on the functional outcomes of ischemic stroke patients: A systematic review and meta‐analysis
Authors: Liu Huarong , Li Bo , Lu Ting , Chen Chong , Xiong Xi , Li Xing , Yang Rengui 
Published: October 2024

AbstractBackground and purposeElevated serum lipoprotein(a) (Lp[a]) levels have been linked to an increased incidence of stroke. This systematic review and meta‐analysis aimed to evaluate the impact of serum Lp(a) on the functional outcomes of patients with ischemic stroke (IS).MethodsWe conducted a comprehensive search of the MEDLINE, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure databases to identify relevant cohort studies. A random effects model was utilized to synthesize the data, accounting for study heterogeneity.ResultsThe analysis included 11 cohort studies comprising 11,958 patients with IS. Pooled results indicated that high baseline Lp(a) levels were associated with an increased risk of poor functional outcomes during follow‐up (odds ratio [OR] = 2.13, 95% confidence interval = 1.67–2.71, p < 0.001, I2 = 62%). Subgroup analyses revealed that the relationship between high Lp(a) levels and the risk of poor functional outcomes was more pronounced at discharge (OR = 3.25), 3 months (OR = 2.02), and 6 months (OR = 2.11) poststroke, compared to 12 months (OR = 1.25, p for subgroup difference < 0.001). Furthermore, the association was attenuated yet remained significant in studies adjusting for low‐density lipoprotein cholesterol (LDL‐C) compared to those that did not adjust for LDL‐C (OR = 1.69 vs. 2.63, p for subgroup difference = 0.03).ConclusionsHigh serum Lp(a) levels at baseline are significantly associated with poor functional outcomes in patients with IS.
Three‐dimensional finite element analysis of the impact of access cavity preparation on first molar fracture resistance: A scoping review
Authors: Zhou Chuang , Pu Ruochen , Liu Bin 
Published: October 2024

AbstractAccess cavity preparation represents the initial step in root canal treatment. Minimally invasive approaches have gained increasing attention and involve advancements in the traditional access cavity preparation. Simultaneously, the development of three‐dimensional finite element analysis (3D‐FEA) has provided a theoretical foundation for evaluating the merits and drawbacks of various access cavity preparations. Studies using static loading 3D‐FEA have suggested that conservative access cavity preparation reduces the concentration of stress in the cervical region, thereby strengthening fracture resistance. However, the lack of support from clinical data raises concerns about the validity of this suggestion. Conversely, studies involving cyclic loading 3D‐FEA and dynamic loading 3D‐FEA have challenged the prevailing perspectives by taking into account additional factors such as filling materials, thus providing a more comprehensive understanding of the impact of access cavity preparation on fracture resistance. Existing research lacks a comprehensive comparison of the different 3D‐FEA methods, and this review fills this gap by providing a systematic assessment of different 3D‐FEA methods and their applications in access cavity preparation.