bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating machine learning and multi-omics analysis to develop an immune-derived multiple programmed cell death signature for predicting clinical outcomes in gastric cancer
Authors: Li Chunhong , Hu Jiahua , Li Mengqin , Fan Xiao , Mao Yiming 
Published: September 2024

Abstract

Objectives
Metastasis of tumor cells is the leading reason for mortality among patients diagnosed with gastric cancer (GC). Emerging evidence indicated a strong correlation between programmed cell death (PCD) and the invasion and metastasis of tumor cells. Therefore, we aimed to develop a programmed cell death signature to assess the prognosis and therapeutic efficacy in GC patients.

Methods
Here, we collected 1911 PCD-related genes from 19 different PCD patterns, and developed an immune-derived multiple programmed cell death index (MPCDI) using the integrating machine learning and multi-omics analysis, and systematically dissected heterogeneity in GC patients. Subsequently, we divided GC patients into two categories, namely high-MPCDI group and low-MPCDI group, using the median MPCDI as the threshold. We performed a comprehensive analysis of the clinical characteristics, somatic mutations, immune infiltration, drug sensitivity, and immunotherapeutic efficacy of the two groups.

Results
Survival and immunotherapy response analyses indicated that the high-MPCDI patients experienced a poorer overall survival (p=0.018) and were more resistant to commonly used chemotherapeutic drugs but benefited from immunotherapy compared to the low-MPCDI patients. In addition, MPCDI was confirmed as a standalone risk factor for overall survival, and nomograms can provide a precise tool for the clinical diagnosis of GC patients.

Conclusions
Taken together, the MPCDI can serve as a robust clinical diagnostic classifier to guide medication administration and improve outcomes in GC patients.
Reducing the severity of incidents or emergency in Estonian emergency calls
Authors: Hennoste Tiit , Rääbis Andriela , Laanesoo-Kalk Kirsi , Rumm Andra 
Published: September 2024

Abstract
The aim of the article is to analyze the calls to the Estonian Emergency Response Centre, focusing on instances where callers reduce the severity of incident or emergency in their first turn. The data comprise 39 calls from the Corpus of Emergency Calls of the University of Tartu. The analysis reveals that callers employ mitigating words and negative turn-initial utterances to reduce the severity. These words indicate the caller’s uncertainty about the information provided or suggest that the reported incident or emergency is minor. The utterances are syntactically and semantically (but not prosodically) completed clauses followed by a second part of the clause construction containing specific information about the caller’s issue. Functionally, these utterances serve as assessments falling into three groups based on the information they project. Some assessments project uncertain information, explicitly expressing uncertainty about the information or using the epistemic marker ma=i=tea ‘I don’t know’. The second group of assessments project information about an incident that the caller does not qualify as an emergency. The last group projects a potential incident or emergency using variants of the utterance ei juhtund midagi ‘nothing happened’. In addition, we offer explanations for why callers reduce the severity of the incident or emergency and demonstrate that reducing severity does not lower the probability of sending assistance. This indicates that call-takers do not rely on callers’ assessments when deciding whether the help is needed.
Effect of ZnO particle size on the radiation shielding efficiency of B2O3–BaO–ZnO glass system
Authors: Almuqrin Aljawhara H. , Sayyed M. I. , Alharbi F.F. , Elsafi M. 
Published: September 2024

Abstract
This study analyzes the ZnO particle size’s effect on glass samples’ radiation shielding ability. Four glass samples with differing micro and nanoparticle ZnO content were investigated at four energies, 0.060, 0.662, 1.173, and 1.333 MeV. The investigated glasses are a B2O3–BaO–ZnO glass system and are composed of 30 % micro ZnO (30 M), 20 % micro ZnO and 10 % nano ZnO (20 M−10 N), 10 % micro ZnO and 20 % nano ZnO (10 M−20 N), and lastly 30 % nano ZnO (30 N). The theoretical XCOM software was employed to validate the experimental LAC values of the glasses, revealing that for at all energies, the values obtained from the two methods agreed with each other well. The glasses’ HVL, MFP, and RSE were then compared. The HVL values at all energies decreased as more nano ZnO was introduced into the glass system, reaching a minimum of 1.947 cm at 0.662 MeV for the 30 N sample. This sample also had the lowest MFP at all energies, while the 30 M glass had the highest, such as 0.088 and 0.070 for 30 M and 30 N respectively at 0.060 MeV. The RSE of a 1 cm thick sample of each of the glasses was tested and found that the 30 N sample exhibited the greatest RSE. The relative percent deviation between the 30 N and 30 M glasses was also analyzed, which highlighted the difference between 30 N’s greater LAC values compared to 30 M at all energies.
Dissecting the immune response of CD4+ T cells in Alzheimer’s disease
Authors: Kostic Milos , Zivkovic Nikola , Cvetanovic Ana , Basic Jelena , Stojanovic Ivana 
Published: September 2024

Abstract
The formation of amyloid-β (Aβ) plaques is a neuropathological hallmark of Alzheimer’s disease (AD), however, these pathological aggregates can also be found in the brains of cognitively unimpaired elderly population. In that context, individual variations in the Aβ-specific immune response could be key factors that determine the level of Aβ-induced neuroinflammation and thus the propensity to develop AD. CD4+ T cells are the cornerstone of the immune response that coordinate the effector functions of both adaptive and innate immunity. However, despite intensive research efforts, the precise role of these cells during AD pathogenesis is still not fully elucidated. Both pathogenic and beneficial effects have been observed in various animal models of AD, as well as in humans with AD. Although this functional duality of CD4+ T cells in AD can be simply attributed to the vast phenotype heterogeneity of this cell lineage, disease stage-specific effect have also been proposed. Therefore, in this review, we summarized the current understanding of the role of CD4+ T cells in the pathophysiology of AD, from the aspect of their antigen specificity, activation, and phenotype characteristics. Such knowledge is of practical importance as it paves the way for immunomodulation as a therapeutic option for AD treatment, given that currently available therapies have not yielded satisfactory results.
Multivariate Stochastic Volatility with Co-Heteroscedasticity
Authors: Chan Joshua , Doucet Arnaud , León-González Roberto , Strachan Rodney W. 
Published: September 2024

Abstract
A new methodology that decomposes shocks into homoscedastic and heteroscedastic components is developed. This specification implies there exist linear combinations of heteroscedastic variables that eliminate heteroscedasticity; a property known as co-heteroscedasticity. The heteroscedastic part of the model uses a multivariate stochastic volatility inverse Wishart process. The resulting model is invariant to the ordering of the variables, which is shown to be important for volatility estimation. By incorporating testable co-heteroscedasticity restrictions, the specification allows estimation in moderately high-dimensions. The computational strategy uses a novel particle filter algorithm, a reparameterization that substantially improves algorithmic convergence and an alternating-order particle Gibbs that reduces the amount of particles needed for accurate estimation. An empirical application to a large Vector Autoregression (VAR) is provided, finding strong evidence for co-heteroscedasticity and that the new method outperforms some previously proposed methods in terms of forecasting at all horizons. It is also found that the structural monetary shock is 98.8 % homoscedastic, and that investment and the SP 500 index are nearly 100 % determined by fat tail heteroscedastic shocks. A Monte Carlo experiment illustrates that the new method estimates well the characteristics of approximate factor models with heteroscedastic errors.
Factors that influence complementarity and competition between medicinal plants and medicines of biomedical origin in an urban context
Authors: Oliveira Bianca Melo , Santoro Flavia Rosa , Ferreira Júnior Washington Soares 
Published: September 2024

Intermedicality is understood as a space of interaction between different medical systems in a given location, which can result in competition or complementarity. In urban environments, intermedicality is common between the biomedical system and other systems. In these scenarios, it is important to understand the therapeutic strategies used by people to treat illnesses, to identify whether the treatment systems adopted lead to competition or complementarity. Among the various factors that can influence these strategies are: people's current and past contact with the rural environment, visits to biomedical environments and socioeconomic factors (income, education and age). This study investigated the therapeutic strategies linked to the complementary or competitive use of medicinal plants and biomedical drugs in an urban environment. The study was carried out in the urban perimeter of the city of Araripina-PE, using an online form addressed to its residents. The form was made up of questions about the therapeutic strategies employed by people, with dissemination through social media and face-to-face visits to institutions and public places. The survey involved 298 residents. Generalized Linear Models, binomial family, were used to assess the effect of the predictor variables on the response variables. As a result, the best-fitting models showed that Complementarity was positively influenced by income and negatively by rural origin, and Competition was positively influenced by rural origin. This study suggests important mechanisms that may be regulating the use of medicinal plants and medicines of biomedical origin exclusively through competition or combined use of these resources in urban contexts.
El diálogo de Melos. Desde la interpretación de Nietzsche hacia la visión trágica de Tucídides
Authors: Colomés Diego 
Published: September 2024

Este trabajo analiza el famoso y “terrible” diálogo que presenta Tucídides en su Guerra del Peloponeso entre los atenienses y los melios y busca destacar elementos que mostrarían una visión trágica de la historia y de los asuntos humanos por parte de su autor. Para ello se utiliza, como elemento heurístico, la interpretación que Nietzsche hizo de este diálogo, específicamente en los parágrafos 92 y 93 de Humano, demasiado humano I. De acuerdo con la interpretación del texto se sugiere que la de Nietzsche es, al menos, incompleta, para afirmar lo cual se usa un esquema de análisis con dos planos: el de lo particular-visible y el de lo general-invisible. La dialéctica entre estos planos, que se expande en el diálogo mismo entre lo que concretamente éste dice y lo que deja en silencio, revelaría en qué medida el análisis de Nietzsche se centra solo en uno de ellos, mientras que el otro, como complemento del primero, revelaría la visión más amplia del propio autor del diálogo como una visión trágica.
¿Se puede tener una experiencia del ser? Fabricación, vivencia y experiencia (Machenschaft, Erlebnis, Erfahrung) en los escritos privados de Heidegger
Authors: Gómez Algarra César 
Published: September 2024

Tal y como expone Heidegger en sus escritos privados de los años 1930-1940, el ser humano hodierno se habría vuelto incapaz de tener una experiencia auténtica (Erfahrung). Puede relacionarse con los entes (Seienden), pero no logra tener una auténtica experiencia del Ser (Seyn), el cual actúa como fundamento de toda experiencia ontológica posible. En este artículo, queremos reconstruir la tesis de una imposibilidad de la experiencia, tal y como la podemos encontrar en los escritos del legado póstumo, recientemente publicados y aún por investigar. Nuestro objetivo es demostrar que esta interpretación histórica, que tanta influencia ha ejercido en la filosofía del siglo XX, no puede interpretarse de forma radical ni sin límites. Si no, corremos el riesgo de quedarnos sin una base fenomenológica capaz de dar cuenta de nuestra experiencia –en cualquiera de sus determinaciones. Heidegger expone un impasse histórico, donde únicamente tenemos una experiencia del ser en su determinación actual y efectiva (Wirklichkeit). Sin embargo, si aceptamos que es tan sólo a partir de una experiencia del Ser que se pueden tener todas las demás experiencias, entonces cerramos los ojos al primer hecho fenomenológico de la donación de la vida –lo que el mismo Heidegger defendió en sus primeros cursos.
The Impact of Technology on Testate Succession in South Africa
Authors: Mahlaela Teresia , Monyamane Lesetja 
Published: September 2024

One advantage of the Fourth Industrial Revolution (4IR) era is the expedient exchange of goods and services via the Internet. The Electronic Communications and Transactions Act 25 of 2002 (ECTA) plays a critical role in regulating transactions and communications. However, ECTA excludes the provisions of the Wills Act 7 of 1953 from its ambit. Inevitably, this creates difficulties for the recognition and/or validity of electronic wills in South Africa. If technology is not acknowledged and applied in the space of testate succession, enhanced 4IR innovations threaten the Wills Act with obsolescence. We argue in this contribution that the rapid changes brought about by the 4IR and the exclusion of the Wills Act from the ambit of ECTA mean that testate succession is not responding to the current impact of technology on people. In this contribution we seek to create a synergy between the two statutes with a view to ensuring the relevance of the Wills Act in the 4IR. Ultimately we propose that both statutes be amended to cater for electronic wills. This can be achieved by combining the use of digital signatures and Public Key Infrastructure (PKI) technology. In reaching this conclusion we draw some lessons from the statutory changes in the United States of America (USA).
GESTÃO PÚBLICA E SUSTENTABILIDADE: DESAFIOS, AÇÕES E POSSIBILIDADES
Authors: Antiqueira Goes Gustavo , Gois Morales Angélica 
Published: September 2024

RESUMO: A gestão pública, pela complexidade que exerce, pode ser olhada como uma área dentro da administração cheia de problemas. Dentre essa complexidade de gestão, deve também ser a principal percussora para a iniciativa de ações de sustentabilidade e de desenvolvimento que estimule a população a adotar práticas ambientais. Portanto, esse o artigo teve como objetivo conceituar gestão pública e sustentabilidade, a fim de uma reflexão da aproximação entre esses dois conceitos que devem estar amplamente interligados, e dos desafios e ações educativas na gestão pública em atuar no caminho da sustentabilidade. Tal reflexão nos permite verificar a diferença da tendência conceitual entre sustentabilidade e desenvolvimento sustentável, bem como compreender que a gestão pública é uma esfera de grande complexidade e que, em primeiro momento é necessário olhar as dificuldades e desafios de cada município para serem superados e alcançados possíveis soluções com base em práticas mais sustentáveis orientado pela educação. Palavras-chave: Gestão pública, Sustentabilidade, Práticas Educativas.
Karakteristik Kimia dan Organoleptik Jelly Drink Galoba (Hornstedtia alliacea) dengan Variasi Konsentrasi Gum Arab
Authors: Tetelepta Gilian , Picauly Priscillia , Breemer Rachel , Polnaya Febby Jeanry , Pays Victory Josef 
Published: September 2024

Tujuan dari penelitian ini adalah menentukan konsentrasi gum arab yang tepat untuk pembuatan jelly drink. Penelitian ini menggunakan Rancangan Acak Lengkap satu faktor yang terdiri dari empat taraf konsentrasi gum arab (0%, 25%, 50%, 75%). Jelly drink dengan konsentrasi gum arab 0,2% menghasilkan nilai pH 3,650, TPT 23,3 oBrix, dan vitamin C 0,42 mg. Jelly drink galoba dengan perlakuan gum arab 0,2% lebih disukai dari segi warna, rasa, tekstur, daya sedot, dan overall, sedangkan berdasarkan mutu hedonik menghasilkan jelly drink galoba dengan warna agak putih keruh (3,0), berasa galoba (3,1), agak kenyal (2,7) dan mudah disedot (4,4).
Nilai Nutrisi Ikan Mas (Cyprinus carpio) Setelah Pembekuan dengan Nitrogen Cair
Authors: Lubis Novriyanti 
Published: September 2024

Nitrogen cair merupakan satu dari beberapa pendingin yang dapat berkontak langsung dengan bahan pangan tanpa menyebabkan efek samping. Nitrogen cair memiliki titik didih pada suhu -195,8°C dan manfaat pembekuan dengan nitrogen cair adalah dapat menghambat pertumbuhan mikroorganisme di dalam produk. Tujuan dari penelitian ini adalah untuk mengidentifikasi sifat kimia ikan Mas (Cyprinus carpio) khususnya terhadap kadar protein dan nilai pH. Metode identifikasi kimia pada penelitian ini dilakukan uji kadar protein dengan metode Kjeldahl dan nilai pH yang diukur dengan pH meter setelah dilakukan metode pembekuan dengan menggunakan nitrogen cair. Rancangan percobaan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) dengan perlakuan M1: ikan segar, M2: pembekuan dengan menggunakan Freezer, M3: pembekuan dengan menggunakan nitrogen cair selama 20 detik, M4: pembekuan dengan menggunakan nitrogen cair selama 40 detik, M5: pembekuan dengan menggunakan nitrogen cair selama 60 detik dan diulang sebanyak 3 kali. Data dianalisis dengan ANOVA dan diuji menggunakan Duncan Multiple Range Test pada taraf =5%. Hasil pada penelitian ini didapat kadar protein tertinggi yaitu ikan segar 25,84% dan ikan dengan pencelupan nitrogen cair selama 60 detik 21,07%, sedangkan kadar protein terendah didapat oleh ikan yang dibekukan dalam Freezer 17,63%, pada hasil analisis nilai pH menunjukkan nilai pH tertinggi didapat oleh ikan segar 6,35% dan ikan dengan pencelupan nitrogen cair selama 60 detik 6,19, sedangkan nilai pH terendah didapat oleh ikan yang dibekukan dalam Freezer 5,73%. Dari ke kelima perlakuan teknik pencelupan menunjukkan bahwa metode pembekuan dengan menggunakan nitrogen cair dapat mempertahankan nilai mutu setelah dilakukan pengujian kimia pada ikan mas.
A IMPORTÂNCIA DA IMUNOFENOTIPAGEM POR CITOMETRIA DE FLUXO NO DIAGNÓSTICO DAS LEUCEMIAS
Authors: Pereira Pontes Alan , Uchôa Guerra Barbosa Eduardo , Felix dos Santos Anderson , Yargo de Freitas Araújo Reis Mysrayn , Uchôa Guerra Barbosa de Lima Carolina 
Published: September 2024

O diagnóstico preciso feito o mais precocemente possível é de suma importância para definir o prognóstico e tratamento adequado da leucemia, e nos últimos anos, novos critérios para o diagnóstico e monitoramento das leucemias são formulados, por sua vez, a citometria de fluxo tornou-se padrão ouro para esses fins, uma vez que sua análise é feita através dos antígenos presentes nas células, conferindo maior especifidade e precisão que a análise citomorfológica. O presente estudo teve como objetivo, realizar uma revisão integrativa sobre a importância da imunofenotipagem por citometria de fluxo para o diagnóstico diferencial dos tipos de leucemia. Durante a pesquisa foram utilizados os operadores booleanos “AND” e “OR” com os seguintes descritores: leucemia aguda; leucemia crônica; citometria de fluxo e imunofenotipagem nas bases de dados do Pubmed, LILACS, SCIELO, Google Acadêmico e livros pertinentes ao tema publicados entre 2013 e 2023 que entornavam a seguinte pergunta norteadora: “Qual a importância da imunofenotipagem por citometria de fluxo no diagnóstico das leucemias e quais são os principais marcadores presentes em cada tipo de leucemia?”. Como resultados, foram obtidos diversos imunofenótipos identificados pela imunofenotipagem apresentados de acordo com o tipo e subtipo de leucemia. O CD13 e CD33, por exemplo, foram um dos principais marcadores presentes na leucemia mieloide aguda, sendo então definidos como um dos principais marcadores para selecionar células da linhagem mieloide. Na LLA de células B também obteve dois marcadores importante para definir a linhagem celular, CD19 e CD22. Portanto, concluiu-se que a imunofenotipagem é um exame de extrema importância para o diagnóstico preciso das leucemias, visto que a análise citomorfológica das células nem sempre é precisa e conclusiva, diferente da imunofenotipagem que possui alta precisão e especifidade por identificar o antígeno presente na célula cancerosa.
Uma jornada de inspiração: o compromisso da Professora Sonia Bertolini com a excelência na Revista Saúde e Pesquisa
Authors: Pestillo de Oliveira Leonardo , Miguel de Sousa Lunet Nuno , Dias Antunes Mateus 
Published: September 2024

É com imenso apreço e gratidão que nos dirigimos aos leitores da Revista Saúde e Pesquisa neste momento singular. Desde a sua concepção em 2008, nossa revista tem sido uma fonte vital de conhecimento e inspiração para a comunidade acadêmica e profissional da área interdisciplinar com foco na prevenção de doenças e promoção e recuperação da saúde. Hoje, é com grande emoção que celebramos não apenas as conquistas acumuladas ao longo desses anos, mas também prestamos homenagem a uma figura excepcional que moldou cada página com dedicação e visão: a Professora Dra. Sonia Maria Marques Gomes Bertolini.

Ao longo dos últimos dezesseis anos, a Dra. Sonia Bertolini tem servido incansavelmente como Editora-Chefe desta revista, liderando-a com paixão, diligência e um compromisso inabalável com a excelência editorial. Sua liderança visionária não apenas estabeleceu os padrões elevados pelos quais a revista é conhecida, mas também promoveu uma cultura de inovação, rigor acadêmico e diversidade de perspectivas.

Sob sua orientação, a Revista Saúde e Pesquisa se tornou um fórum dinâmico para o intercâmbio de ideias, descobertas e práticas inovadoras em saúde, abrangendo uma ampla gama de disciplinas e tópicos. Seu compromisso com a qualidade acadêmica e a integridade editorial ajudou a solidificar a reputação da revista como uma publicação de destaque em seu campo.

Além de sua liderança editorial exemplar, a Dra. Sonia Bertolini também personifica os valores fundamentais que a revista busca promover: integridade, colaboração e empenho no avanço do conhecimento em saúde. Sua dedicação incansável em apoiar autores, revisores e membros da equipe editorial demonstra um profundo compromisso com a comunidade que serve.

À medida que nos despedimos da Dra. Sonia Bertolini em sua função como Editora-Chefe, expressamos nossa mais profunda gratidão por sua dedicação e contribuições inestimáveis ao longo dos anos. Seu legado perdurará não apenas nas páginas desta revista, mas também nos corações e mentes daqueles que tiveram o privilégio de trabalhar ao seu lado.

À medida que a Revista Saúde e Pesquisa embarca em um novo capítulo de sua história, estamos confiantes de que os alicerces sólidos estabelecidos pela Dra. Sonia Bertolini continuarão a inspirar e orientar nosso caminho adiante. Enquanto damos as boas-vindas a uma nova liderança editorial, permanecemos comprometidos com os mais altos padrões de excelência, ética e relevância para nossa comunidade de leitores e colaboradores.

Por fim, gostaríamos de estender nossa mais sincera gratidão à Dra. Sonia Bertolini por sua dedicação exemplar e desejar-lhe todo o sucesso em seus projetos futuros. Que sua jornada continue a ser marcada por realizações notáveis e impacto duradouro, assim como seu tempo à frente da Revista Saúde e Pesquisa.

Com estima e reconhecimento,

A equipe editorial da Revista Saúde e Pesquisa