bluuebunny/crossref_metadata_2025_split huggingface dataset:
mRNA transport in fungal top models
Authors: Niessing Dierk , Jansen Ralf‐Peter , Pohlmann Thomas , Feldbrügge Michael 
Published: October 2017

Eukaryotic cells rely on the precise determination of when and where proteins are synthesized. Spatiotemporal expression is supported by localization of mRNAs to specific subcellular sites and their subsequent local translation. This holds true for somatic cells as well as for oocytes and embryos. Most commonly, mRNA localization is achieved by active transport of the molecules along the actin or microtubule cytoskeleton. Key factors are molecular motors, adaptors, and RNA‐binding proteins that recognize defined sequences or structures in cargo mRNAs. A deep understanding of this process has been gained from research on fungal model systems such as Saccharomyces cerevisiae and Ustilago maydis. Recent highlights of these studies are the following: (1) synergistic binding of two RNA‐binding proteins is needed for high affinity recognition; (2) RNA sequences undergo profound structural rearrangements upon recognition; (3) mRNA transport is tightly linked to membrane trafficking; (4) mRNAs and ribosomes are transported on the cytoplasmic surface of endosomes; and (5) heteromeric protein complexes are, most likely, assembled co‐translationally during endosomal transport. Thus, the study of simple fungal model organisms provides valuable insights into fundamental mechanisms of mRNA transport boosting the understanding of similar events in higher eukaryotes. WIREs RNA 2018, 9:e1453. doi: 10.1002/wrna.1453This article is categorized under:

RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition
RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes
RNA Export and Localization > RNA Localization
Meeting report of the 8th International Conference on cGMP “cGMP: generators, effectors, and therapeutic implications” at Bamberg, Germany, from June 23 to 25, 2017
Authors: Friebe Andreas , Sandner Peter , Schmidtko Achim 
Published: October 2017

Abstract
Although the Nobel Prize for the discovery of nitric oxide (NO) dates back almost 20 years now, the knowledge about cGMP signaling is still constantly increasing. It looks even so that our understanding of the role of the soluble guanylyl cyclase (sGC) and particulate guanylyl cyclase (pGC) in health and disease is in many aspects at the beginning and far from being understood. This holds even true for the therapeutic impact of innovative drugs acting on both the NO/sGC and the pGC pathways. Since cGMP, as second messenger, is involved in the pathogenesis of numerous diseases within the cardiovascular, pulmonary, renal, and endocrine systems and also plays a role in neuronal, sensory, and tumor processes, drug applications might be quite broad. On the 8th International Conference on cGMP, held in Bamberg, Germany, world leading experts came together to discuss these topics. All aspects of cGMP research from the basic understanding of cGMP signaling to clinical applicability were discussed in depth. In addition, present and future therapeutic applications of cGMP-modulating pharmacotherapy were presented (http://www.cyclicgmp.net/index.html).
Synthesis, Characterization, Surface Properties and Micellization Behaviour of Imidazolium‐based Ionic Liquids
Authors: Pillai Prathibha , Pal Nilanjan , Mandal Ajay 
Published: October 2017

AbstractIonic liquids (IL) have emerged as a prospective new material for a wide range of industrial applications, owing to their unique structures and properties. Hence, understanding the structure–property relationships of IL is very important for both fundamental and industrial applications. In this study, a series of imidazolium‐based IL with different chain lengths, namely C8mimBF4, C10mimBF4 and C12mimBF4, were synthesized. Their molecular structures were confirmed by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FTIR) analysis. Thermal gravimetric analysis (TGA) revealed that the IL synthesized were thermally stable in the desired temperature range. Dynamic light scattering (DLS) results of IL was analyzed in order to understand the effect of alkyl length on micellar size. Conductivity and surface tension measurements were carried out to determine the adsorption and aggregation characteristics in aqueous solutions. The influences of temperature as well as alkyl chain length on viscosity were also investigated. Surface adsorption parameters such as surface excess, minimum area, effectiveness and efficiency were also determined from equilibrium surface tension data. A careful analysis of the thermodynamic aspects of air‐ionic liquid aqueous systems reveals that free energies of adsorption are favoured over micellization for all systems.
Stereotactic body radiation therapy for non-small cell lung cancer patients with prior history of thoracic surgery and/or radiation therapy: the influence of smoking, size, and central location on risk of complications
Authors: Chan Jason W. , Johnson Julian , Lazar Ann A. , Braunstein Steve E. , Descovich Martina , Gottschalk Alexander R. , Yom Sue S. 
Published: October 2017

AbstractPurposeThe purpose of this retrospective cohort study was to evaluate the effect of tumor location and other major factors on the risk of complications from stereotactic body radiation therapy (SBRT) in non-small cell lung cancer (NSCLC) patients with a history of thoracic surgery and/or radiation therapy.MethodsMedical records of patients with recurrent or second primary NSCLC treated with SBRT between 2005 and 2015 were reviewed. All patients had prior thoracic surgery and/or radiation therapy and were treated with image-guided, robotic SBRT. Time to local failure and toxicity was evaluated by using cumulative incidence and competing risk regression analysis. Overall survival was estimated using the Kaplan-Meier method.ResultsFifty-six patients with 74 tumors treated with SBRT were included for analysis. Of the 74 tumors, 19 (26%) were centrally located within 2 cm of the proximal bronchial tree. At a median follow-up of 27 months (range = 5–129), the 2-year cumulative incidence of LF was 13% for peripheral tumors and 16% for central tumors (p = 0.95). Neither prior thoracic surgery nor radiation therapy was associated with increased LF or toxicity. Among the 56 patients, eight (14%), three (5%), and one (2%) experienced grade 2, 3, and 4 complications following SBRT. Patients with a ≥ 50 pack-year smoking history were more likely to develop ≥ grade 2 toxicity (HR 5.3; 95% CI 1.4–19.9,p = 0.01). Central tumor location was associated with higher risk of toxicity (HR 3.4; 95% CI 1.1–10.5,p = 0.04) as was planning tumor volume > 30 mL (HR 4.3; 95% CI 1.1–16.3,p = 0.047). In a multivariable model, central location remained significant after adjusting for smoking history and planning tumor volume.ConclusionsAfter prior thoracic surgery and/or radiation, SBRT retreatment for NSCLC provided durable local control and was well tolerated in most patients. Patients with a history of previously operated and/or radiated lung cancer with new central tumors, PTV volume > 30 mL, or smoking history ≥ 50 pack-years were at higher risk of complications from SBRT.
Sensitivity of mountain glacier mass balance to changes in bare-ice albedo
Authors: Naegeli Kathrin , Huss Matthias 
Published: October 2017

ABSTRACTAlbedo is an important parameter in the energy balance of bare-ice surfaces and modulates glacier melt rates. The prolongation of the ablation period enforces the albedo feedback and highlights the need for profound knowledge on impacts of bare-ice albedo on glacier mass balance. In this study, we assess the mass balance sensitivity of 12 Swiss glaciers with abundant long-term in-situ data on changes in bare-ice albedo. We use pixel-based bare-ice albedo derived from Landsat 8. A distributed mass-balance model is applied to the period 1997–2016 and experiments are performed to assess the impact of albedo changes on glacier mass balance. Our results indicate that glacier-wide mass-balance sensitivities to changes in bare-ice albedo correlate strongly with mean annual mass balances (r2= 0.81). Large alpine glaciers react more sensitively to bare-ice albedo changes due to their ablation areas being situated at lower elevations. We find average sensitivities of glacier-wide mass balance of −0.14 m w.e. a−1per 0.1 albedo decrease. Although this value is considerably smaller than sensitivity to air temperature change, we stress the importance of the enhanced albedo feedback that will be amplified due to atmospheric warming and a suspected darkening of glacier surface in the near future.
Perceived Workplace Interpersonal Support Among Workers of the Fukushima Daiichi Nuclear Power Plants Following the 2011 Accident: The Fukushima Nuclear Energy Workers’ Support (NEWS) Project Study
Authors: Takahashi Sho , Shigemura Jun , Takahashi Yoshitomo , Nomura Soichiro , Yoshino Aihide , Tanigawa Takeshi 
Published: October 2017

AbstractObjectiveThe 2011 Fukushima Daiichi nuclear accident was the worst nuclear disaster since Chernobyl. The Daiichi workers faced multiple stressors (workplace trauma, victim experiences, and public criticism deriving from their company’s post-disaster management). Literatures suggest the importance of workplace interpersonal support (WIS) in enhancing psychological health among disaster workers. We sought to elucidate the role of their demographics, disaster-related experiences, and post-traumatic stress symptoms on perceived WIS.MethodsWe analyzed self-report questionnaires of 885 workers 2-3 months post-disaster. We used sociodemographic and disaster exposure-related variables and post-traumatic stress symptoms (measured by the Impact of Event Scale-Revised) as independent variables. We asked whether WIS from colleagues, supervisors, or subordinates was perceived as helpful, and used yes or no responses as a dependent variable. Logistic regression analyses were performed to assess correlates of WIS.ResultsOf the participants, one-third (34.7%) reported WIS. WIS was associated with younger age (20-28 years [vs 49-], adjusted odds ratio [aOR]: 3.25, 95% CI: 1.99-5.32), supervisory work status (aOR: 2.30, 95% CI: 1.35-3.92), and discrimination or slur experience (aOR: 1.65, 95% CI: 1.08-2.53).ConclusionsEducational programs focusing on WIS might be beneficial to promote psychological well-being among nuclear disaster workers, especially younger workers, supervisors, and workers with discrimination experiences. (Disaster Med Public Health Preparedness. 2018;12:460–463)
Catching up: the state and potential of historical catch data from Svalbard in the European Arctic
Authors: Kruse Frigga 
Published: October 2017

ABSTRACTSvalbard in the European Arctic has a well-documented history of natural resource exploitation. Since its discovery in 1596, the archipelago has witnessed phases of commercial whaling, sealing, fur hunting and fishing. Scientists, trophy hunters and miners have also added to the depletion of wildlife. The magnitude, scale and speed of the hunt, however, remain largely unknown. This paper collates historical catch data of five selected species of game animal from published written and archaeological sources. These species include the bowhead whale, the Atlantic walrus, the polar bear, the Arctic fox and the Svalbard reindeer. The paper thereby aims to quantify the anthropogenic pressure on Svalbard's ecosystems over more than four centuries. This quantification is only moderately successful. The incomplete record prevents the use of this catch data as a suitable indicator of human-induced ecosystem change. To advance the state of knowledge, the paper recommends a return to the primary sources across international archives, libraries and museum collections, and outlines steps with which to arrive at the much needed time-depth in Svalbard historical ecology.
The race paradox in subjective wellbeing among older Americans
Authors: TANG FENGYAN , JANG HEEJUNG , RAUKTIS MARY BETH , MUSA DONALD , BEACH SCOTT 
Published: October 2017

ABSTRACTThis study aims to assess racial differences in subjective wellbeing (SWB) and to examine whether the pathways of social support and social engagement to SWB vary by racial groups in the United States of America. Using a local sample (N = 1,035) and a nationally representative sample of the Health and Retirement Study (N = 7,718), we compared life satisfaction and happiness between non-Hispanic Whites and Blacks aged 55 and over. We evaluated the extent to which race, other socio-demographic characteristics, health, social engagement and social support explained the variances in SWB and examined the moderation effects of race on the relationships of SWB with age, social support and social engagement. Multiple regression analyses showed that non-Hispanic Blacks were at least as satisfied as, and even happier than White peers, after equalising social resources and health variables. Social support was significantly related to SWB, and it seemed that positive support was more important to Whites than to Blacks in predicting life satisfaction. In addition, the racial crossover effect existed, that is, the old-old (80+) Blacks were happier than their White peers. Findings indicate a national trend of the race paradox in SWB and underscore the importance of social support in promoting older adults’ wellbeing. Future research is recommended to investigate other potential mechanisms among Black older Americans to explain their relatively better SWB.
Trends in Political Science Research and the Progress of Comparative Politics
Authors: Wilson Matthew Charles 
Published: October 2017

ABSTRACT
This article illustrates major trends in political science research and frames the progress of research agendas in comparative politics. Drawing on the titles and abstracts of every article published in eight major political science journals between 1906 and 2015, the study tracks the frequency of references to specific keywords over time. The analysis corresponds to and complements extant descriptions of how the field has developed, providing evidence of three ‘revolutions’ that shaped comparative politics—the divorce of political science from history during its early years, a behavioral revolution that lasted until the late 1960s, and a second scientific revolution after 1989 characterized by greater empiricism. Understanding the development of the subdiscipline, and viewing it through the research published in political science over the last 100 years, provides useful context for teaching future comparativists and encourages scholars to think more broadly about the research traditions to which they are contributing.
Pushing the Envelope of Pedagogical Gaming: Dark Networks
Authors: Freeman Michael E. 
Published: October 2017

ABSTRACT
In recent decades, instructors have increasingly adopted the use of “serious” games in their classrooms. Typically, these games take the form of role-playing simulations or wargames. However, online computer-run games have opened up new possibilities: to explore complex conceptual relationships, to utilize and display asymmetric information, to be playable anywhere and by anyone, and more. This article describes the game, Dark Networks, and shows why this type of game is valuable as well as how it has been used for pedagogical gains.
Productivity and water use of organic wheat–chickpea intercropping system under limited moisture conditions in Northwest India
Authors: Singh Balwinder , Aulakh C.S. , Walia S.S. 
Published: October 2017

AbstractIntercropping of legumes in cereals and manuring are important measures to sustain soil fertility and enhance crop productivity in general and under organic and limited moisture conditions in particular. This study evaluated different wheat (Triticum aestivum L.) + chickpea (Cicer arietinum L.) row ratios as intercrops under organic and limited moisture conditions in Northwest India with an aim to find out the suitable row ratio to get higher system productivity under these conditions. Chickpea, being a legume, produces nitrogen compounds that help the plant to grow itself and also makes them available to the companion wheat plants and thus helps in wheat nutrition, which otherwise becomes limited due to less mineralization of nitrogen under organic and cold weather conditions. The primary aim of the study was to get better productivity of wheat crop as this is an assured crop of this region. The intercropping system was evaluated in a randomized complete block design with four replications at Ludhiana, Punjab in Northwest India during 2013–2014 and 2014–2015. Effective tillers m−1 row length, number of grains spike−1 and 1000-grain weight of wheat were higher in wheat + chickpea (2:1) intercropping system as compared with sole wheat. This intercropping system produced significantly higher wheat grain yield, wheat equivalent yield and land equivalent ratio than sole wheat. Wheat + chickpea (2:1) and wheat + chickpea (3:1) intercropping systems gave higher water-use efficiency than sole wheat. However, chickpea gave higher yield attributes and seed yield as sole crop than that in different intercropping systems. Wheat + chickpea (2:1) and wheat + chickpea (3:1) intercropping systems produced mean wheat grain yields of 5.11 and 4.79 Mg ha−1, respectively, along with additional mean chickpea seed yields of 0.28 and 0.24 Mg ha−1, respectively.
Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment
Authors: Nakamura Yukio , Suzuki Takako , Kamimura Mikio , Murakami Kohei , Ikegami Shota , Uchiyama Shigeharu , Kato Hiroyuki 
Published: October 2017

AbstractTo evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group (18 cases) or a denosumab plus vitamin D supplementation group (combination group; 23 cases). We measured serum bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase (TRACP)-5b and urinary N-terminal telopeptide of type-I collagen (NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months. We also measured bone mineral density (BMD) of L1–4 lumbar vertebrae (L)-BMD and bilateral hips (H)-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5b and urinary NTX were significantly suppressed in both groups from 1 week to 12 months (except at 12 months for NTX). In the combination group, TRACP-5b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months (P<0.05). BAP was significantly suppressed in both groups at 2–12 months. L-BMD significantly increased at 8 and 12 months (8.9%) in the combination group and at 4, 8 and 12 months (6.0%) in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group (3.6%) compared with the denosumab group (1.2%) at 12 months (P<0.05). Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD (especially at the hips).
Advances in the management of oesophageal motility disorders in the era of high-resolution manometry: a focus on achalasia syndromes
Authors:   on behalf of the International Working Group for Disorders of Gastrointestinal Motility and Function, Kahrilas Peter J. , Bredenoord Albert J. , Fox Mark , Gyawali C. Prakash , Roman Sabine , Smout André J.P.M. , Pandolfino John E. 
Published: October 2017

Abstract
High-resolution manometry (HRM) and new analysis algorithms, summarized in the Chicago Classification, have led to a restructured classification of oesophageal motility disorders. This advance has led to increased detection of clinically relevant disorders, in particular achalasia. It has become apparent that the cardinal feature of achalasia — impaired lower oesophageal sphincter (LES) relaxation — can occur in several disease phenotypes: without peristalsis (type I), with pan-oesophageal pressurization (type II), with premature (spastic) distal oesophageal contractions (type III), or with preserved peristalsis (outlet obstruction). Furthermore, no manometric pattern is perfectly sensitive or specific for achalasia caused by a myenteric plexopathy, and there is no biomarker for this pathology. Consequently, physiological testing reveals other syndromes not meeting achalasia criteria that also benefit from therapies formerly reserved for achalasia. These findings have become particularly relevant with the development of a minimally invasive technique for performing a long oesophageal myotomy, the per-oral endoscopic myotomy (POEM). Optimal management is to render treatment in a phenotype-specific manner; that is, POEM calibrated to patient-specific physiology for spastic achalasia and the spastic disorders, and more conservative strategies such as pneumatic dilation for the disorders limited to the LES. This Consensus Statement examines the effect of HRM on our understanding of oesophageal motility disorders, with a focus on the diagnosis, epidemiology and management of achalasia and achalasia-like syndromes.
Origami-based tunable truss structures for non-volatile mechanical memory operation
Authors: Yasuda Hiromi , Tachi Tomohiro , Lee Mia , Yang Jinkyu 
Published: October 2017

AbstractOrigami has recently received significant interest from the scientific community as a method for designing building blocks to construct metamaterials. However, the primary focus has been placed on their kinematic applications by leveraging the compactness and auxeticity of planar origami platforms. Here, we present volumetric origami cells—specifically triangulated cylindrical origami (TCO)—with tunable stability and stiffness, and demonstrate their feasibility as non-volatile mechanical memory storage devices. We show that a pair of TCO cells can develop a double-well potential to store bit information. What makes this origami-based approach more appealing is the realization of two-bit mechanical memory, in which two pairs of TCO cells are interconnected and one pair acts as a control for the other pair. By assembling TCO-based truss structures, we experimentally verify the tunable nature of the TCO units and demonstrate the operation of purely mechanical one- and two-bit memory storage prototypes.
A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
Authors: Elkis Yoav , Cohen Moshe , Yaffe Etai , Satmary-Tusk Shirly , Feldman Tal , Hikri Elad , Nyska Abraham , Feiglin Ariel , Ofran Yanay , Shpungin Sally , Nir Uri 
Published: October 2017

AbstractDisruption of the reprogrammed energy management system of malignant cells is a prioritized goal of targeted cancer therapy. Two regulators of this system are the Fer kinase, and its cancer cell specific variant, FerT, both residing in subcellular compartments including the mitochondrial electron transport chain. Here, we show that a newly developed inhibitor of Fer and FerT, E260, selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level. Notably, Fer was also found to associate with PARP-1 and E260 disrupted this association thereby leading to PARP-1 activation. The cooperative intervention with these metabolic pathways leads to energy crisis and necrotic death in malignant, but not in normal human cells, and to the suppression of tumors growth in vivo. Thus, E260 is a new anti-cancer agent which imposes metabolic stress and cellular death in cancer cells.