bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scope for sympatric giant-dwarf speciation driven by cannibalism in South-American annual killifish (Austrolebias)
Authors: Van Dooren Tom JM , Thomassen Henri A , Smit Femmie , Helmstetter Andrew J , Savolainen Vincent 
Published: March 2017

AbstractA trophic radiation in the South-American annual killifish genusAustrolebiashas led to the evolution of large specialized piscivores from small generalized carnivores. It has been proposed that this occurred in a single series of vicariant speciation events. An alternative hypothesis is denoted giant-dwarf speciation: piscivores would have evolved in sympatry by character displacement and cannibalism. We test the plausibility of both scenarios using size measures combined with distributional data and new phylogenetic trees based on mitochondrial and nuclear molecular markers.Our analysis uses historical biogeography models and Ornstein-Uehlenbeck processes describing trait evolution across the posterior distributions of phylogenetic trees. Large species most likely evolved three times from small ones. For the clade containingA. elongatus, we argue that vicariance was not involved in the origin of these large and specialized piscivores. They experience stabilizing selection with an optimum shifted towards larger bodies and longer jaws. The branch leading to this clade has the fastest evolving jaw lengths across the phylogeny, in agreement with expectations for giant-dwarf speciation. ForA. wolterstorffi, the support for giant-dwarf speciation is weaker. When the species is placed at the root ofAustrolebias, ancestral reconstructions are unreliable and vicariance cannot be ruled out. For the remaining large species, we can reject vicariance and giant dwarf speciation. Our results give rise to two new additional scenarios for the evolution of specialized piscivores. In the first, two successive speciation events in sympatry or parapatry produced large and piscivorous species. In the second, the immigration of a different annual killifish genus (Cynopoecilus) in the Patos area of endemism has contributed to in-situ diversification ofAustrolebiasspecies.
phydms: Software for phylogenetic analyses informed by deep mutational scanning
Authors: Hilton Sarah K. , Doud Michael B , Bloom Jesse D 
Published: March 2017

AbstractBackgroundThe evolution of protein-coding genes can be quantitatively modeled using phylogenetic methods. Recently, it has been shown that high-throughput experimental measurements of mutational effects made via deep mutational scanning can inform site-specific phylogenetic substitution models of gene evolution. However, there is currently no software tailored for such analyses.ResultsWe describe software that efficiently performs phylogenetic analyses with substitution models informed by deep mutational scanning. This software, phydms, is ∼100-fold faster than existing programs that accommodate such substitution models. It can be used to compare the results of deep mutational scanning experiments to the selection on genes in nature. For instance, phydms enables rigorous comparison of how well different experiments on the same gene describe natural selection. It also enables the re-scaling of deep mutational scanning data to account for differences in the stringency of selection in the lab and nature. Finally, phydms can identify sites that are evolving differently in nature than expected from experiments in the lab.ConclusionsThe phydms software makes it easy to use phylogenetic substitution models informed by deep mutational scanning experiments. As data from such experiments becomes increasingly widespread, phydms will facilitate quantitative comparison of the experimental results to the actual selection pressures shaping evolution in nature.
The non-linear development of the right hemispheric specialization for human face perception
Authors: Lochy Aliette , de Heering Adelaïde , Rossion Bruno 
Published: March 2017

AbstractThe developmental origins of human adults’ right hemispheric specialization for face perception remain unclear. On the one hand, infant studies have generally shown a right hemispheric advantage for face perception. On the other hand, the adult right hemispheric lateralization for face perception is thought to slowly emerge during childhood, due to reading acquisition, which increases left lateralized posterior responses to competing written material (i.e., visual letters and words). Since methodological approaches used in infant and children usually differ, resolving this issue has been difficult. Here we tested 5-year-old preschoolers varying in their level of visual letter knowledge with the same fast periodic visual stimulation (FPVS) paradigm leading to strongly right lateralized electrophysiological occipito-temporal face-selective responses in 4- to 6-month-old infants (de Heering & Rossion, 2015). Children’s face-selective response was much larger and more complex than in infants, but did not differ across hemispheres. However, there was a small positive correlation between preschoolers’ letter knowledge and their right hemispheric specialization for faces. These observations suggest that several factors contribute to the adult right hemispheric lateralization for faces, and point to the value of FPVS coupled with electroencephalography to assess specialized face perception processes throughout development with the same methodology.
Real-time observation of flexible domain movements in Cas9
Authors: Osuka Saki , Isomura Kazushi , Kajimoto Shohei , Komori Tomotaka , Nishimasu Hiroshi , Shima Tomohiro , Nureki Osamu , Uemura Sotaro 
Published: March 2017

ABSTRACTThe CRISPR-associated protein Cas9 is a widely used genome editing tool that recognizes and cleaves target DNA through the assistance of a single-guide RNA (sgRNA). Structural studies have demonstrated the multi-domain architecture of Cas9 and sequential domain movements upon binding to the sgRNA and the target DNA. These studies also hinted at the flexibility between domains, but whether these flexible movements occur in solution is unclear. Here, we directly observed dynamic fluctuations of multiple Cas9 domains, using single-molecule FRET. The flexible domain movements allow Cas9 to adopt transient conformations beyond those captured in the crystal structures. Importantly, the HNH nuclease domain in Cas9 only accessed the DNA cleavage position during such flexible movements, suggesting the importance of this flexibility in the DNA cleavage process. Our FRET data also revealed the conformational flexibility of apo-Cas9, which may play a role in the assembly with the sgRNA. Collectively, our results highlight the potential role of domain fluctuations in driving Cas9-catalyzed DNA cleavage.
Cross-talk between active DNA demethylation, resetting of cellular metabolism and shoot apical growth in poplar bud break
Authors: Conde Daniel , Perales Mariano , Le Gac Anne-Laure , Dervinis Christopher , Kirst Matias , Maury Stéphane , González-Melendi Pablo , Allona Isabel 
Published: March 2017

AbstractAnnual dormancy-growth cycle is a developmental and physiological process essential for the survival of temperate and boreal forests. Seasonal control of shoot growth in woody perennials requires specific genetic programs integrated with the environmental signals. The environmental-controlled mechanisms that regulate the shift between winter dormancy to growth promoting genetic program are still unknown. Here, we show that dynamics in genomic DNA methylation (gDNA) levels regulate dormancy-growth cycle in poplar. We proved that the reactivation of cell division in the apical shoot that lead bud break process in spring, is preceded by a progressive reduction of gDNA methylation in apex tissue. We also identified that the induction in apex tissue of a chilling-dependent poplarDEMETER-LIKE 10(PtaDML10) DNA demethylase precedes shoot growth reactivation. Transgenic poplars showing down-regulation of PtaDML8/10 caused delayed bud break. Genome wide transcriptome and methylome analysis and data mining revealed the gene targets of active DML-dependent DNA demethylation genetically associated to bud break. These data point to a chilling dependent-DEMETER-like DNA demethylase controlling the genetic shift from winter dormancy to a condition that promotes shoot apical vegetative growth in poplar.
Testing solutions of a multi-disaster building’s certification functional to the built environment sustainability and resilience
Authors: Bignami Daniele Fabrizio 
Published: March 2017

Purpose
This paper aims to present phenomenological extensions and technical improvements of a recent research path on a potential operational scheme aiming at promoting an effective disasters risk reduction of built urban areas, namely, the proposal of a Certification of the Predisposition of Resistance of Edifices to Disasters.

Design/methodology/approach
The authors illustrate new steps of a multidisciplinary research conducted by merging different fields of study, such as disaster risk analysis, sustainable land use and urban planning, environmental assessment methods, different buildings safety topics and certification and auditing management systems tools.

Findings
This work is based on research developed in Italy by carrying out new tests in the coastal regions of Liguria and Tuscany to validate improvements and to confirm in different territories the assessment process of most significant natural and man-made hazards already included in the certification scheme previously developed on the basis of the continental regions of Lombardy and Piedmont.

Originality/value
Investigations and results give firmer foundations and exploitability to a certification such as the one presented here.
The interplay between key marketing and supply chain management capabilities: the role of integrative mechanisms
Authors: Golgeci Ismail , Gligor David M. 
Published: March 2017

PurposeThis paper aims to identify key marketing and supply chain management-related (supply chain management – SCM) capabilities and explore the nature of the linkages between these specific capabilities as shaped by the integrative mechanisms adopted by firms.Design/methodology/approachBased on the findings from dyadic interviews with 26 marketing and SCM executives from business-to-business firms, the authors develop an empirically grounded conceptual framework.FindingsThe authors identify innovativeness and market learning capability as key marketing capabilities and supply chain agility and relational capability as key SCM capabilities. The authors find that relationships between these strategic marketing and SCM capabilities follow a specific pattern. The authors also find that the application of unique integrative mechanisms can cultivate the potential tandem between marketing and SCM capabilities.Research limitations/implicationsThe study informs theory with regard to two key areas: relationships among key marketing and SCM capabilities and integrative mechanisms that shape the underlying mechanisms of capability relationships.Practical implicationsApplication of organizational dynamics to key marketing and SCM provides a more nuanced understanding of the linkages among such capabilities. A better understanding and application of integrative mechanisms may help managers to develop better tools and means to bundle their key marketing and SCM capabilities effectively.Originality/valueThe qualitative and exploratory nature of the paper will be of significant interest to managers who would like to achieve greater synergy between marketing and SCM capabilities.
The influence of economic crises on network behavior
Authors: Mandják Tibor , Wimmer Ágnes , Durrieu François 
Published: March 2017

Purpose
Following industrial network theory, this paper aims to address network behavior from a focal company’s perspective. Special attention is paid to examining the effect of perceptions of the economic crisis on network behavior.

Design/methodology/approach
The study is built on a quantitative analysis of an empirical database of 300 companies based on a survey completed in 2013 in Hungary. A focal company network behavior model was developed and applied to investigate the link between variables (valuable customer relationships, valuable supplier relationships, relationship strategy and relational outcomes) and the effect of managers’ perceptions about the intensity of the crisis. To obtain a deeper understanding of the effect of the crisis, structural modeling methodology was applied during data analysis.

Findings
How crises are perceived has a moderating influence on companies’ network behavior. In a context in which a crisis is strongly perceived, valuable customer relationships are considered more important than valuable supplier relationships; relationship strategy becomes more intensive; and performance is increasingly focused on operations and less on innovation. The main difference in network behavior is found with the management of the supply side. A different level of attention is paid to supplier relationships in a high crisis-perception context than when a crisis is perceived as being less critical.

Research limitations/implications
Results emphasize the importance of perceptions as a key factor in managerial attitudes, behavior and, ultimately, decision-making. This finding merits more attention from both researchers of business relationships and networks.

Practical implications
From a managerial point of view, the results emphasize the existence of potentially new opportunities in network management. The reinforcement of attention to the customer during a period of crisis implies the importance of the customer orientation, but also suggests that firms may have unexploited opportunities and more potential resources on the supplier side.

Originality/value
The paper combines an analysis of network behavior and perceptions of crisis, helping to explain managerial decisions and attitudes. Analysis was undertaken from a focal firms’ perspective and differences were investigated in attitudes concerning both supplier- and customer-side relations. How crises are perceived is a moderating variable of network behavior.
Organizational structure, innovation performance and customer relationship value in the Greek advertising and media industry
Authors: Dekoulou Paraskevi , Trivellas Panagiotis 
Published: March 2017

PurposeThis paper aims to explore the impact of organizational structure dimensions on innovation performance as well as its implications on business customers’ relationship value and financial performance in the business-to-business (B2B) market of the Greek advertising and media industry.Design/methodology/approachBased on a sample of 180 executives, who are at the helm of 163 Greek advertising and media organizations, the authors apply the partial least square method to test the association of organizational structure with innovation performance, business customers’ relationship value and financial outcomes.FindingsFindings have brought to light that training boosts organization’s capacity to innovate, whereas direct supervision as a coordination mechanism significantly restricts this capacity. Innovation performance in the advertising B2B market fosters business customers’ relationship value and financial performance, while financial outcomes are also beneficially affected by profitable relationships with customer relationship value.Practical implicationsBecause of the dramatic decline in their profitability caused by the economic crisis in the past five years, Greek advertising and media companies are threatened with extinction; thus, they are required to enhance their effectiveness through the adoption of a more innovation-oriented structure. Thus, managers should facilitate structures supporting training and delimiting direct supervision to foster the development of a competitive advantage built on innovation, creativity and business clients’ relationship.Originality/valueThis study contributes to the existing relationship marketing literature because it introduced Mintzberg’s typology to measure organizational structure and led to the diagnosis of the associations between different dimensions of organizational structure and various aspects of performance in the media and advertising industry, revealing the partial mediating role of customer relationship value between innovation and financial performance in the B2B market.
The impact of trust and commitment on value creation in asymmetric buyer–seller relationships: the mediation effect of specific asset investments
Authors: Chen Po-Yuan , Chen Kuan-Yang , Wu Lei-Yu 
Published: March 2017

PurposePrevious studies have argued that trust and commitment can create value in cooperative relationships. However, this study observed that, in practice, trust and commitment alone may not ensure value creation in asymmetric relationships. Accordingly, this study aims to investigate the mediating role of specific assets in the effects of trust and commitment on value creation in asymmetric buyer–seller relationships.Design/methodology/approachContract manufacturers (CMs) in Asia were sampled to validate the argument proposed by this study. Most Taiwanese CMs are partnered with international brands (original equipment manufacturers [OEMs]) that have stronger bargaining power. This cooperative relationship is characteristically asymmetric. A questionnaire method was applied, and structural equation modeling was performed to verify the proposed hypotheses.FindingsSpecific asset investment (SAI) was a crucial mediator that explained the effects of trust and commitment on the relationship value of an asymmetric cooperative relationship. Past studies have claimed that power asymmetry results in an unequal distribution of benefits. Nevertheless, regarding the relationship between CMs and OEMs, the study revealed that relationship value could still be increased once the congruent goals have been achieved by both parties. This finding contradicts past theoretical predictions.Practical implicationsCharacteristically asymmetric CMs–OEMs (seller–buyer) relationships cannot be maintained merely through trust and commitment, particularly in the context of power and resource imbalances in which the stronger party often possesses a wider selection of prospective partners. The results of this study suggested that the CM should unilaterally invest in specific assets conducive to a cooperative relationship as an expression of faith in the relationship with the stronger firm, thereby creating opportunities for value cocreation.Originality/valueThe analysis of the relevance of relationship quality in the context of asymmetric cooperative relationships confirmed the mediating influences of SAI on ensuring value creation and the maintenance of the relationships. Relationship value could still be created despite the highly asymmetry power relationship. The CMs’ SAI is the key mechanism for this achievement.
Improving performance and curtailing opportunism: the role of contractual issue inclusiveness and obligatoriness in channel relationships
Authors: Yang Pianpian , Qian Liping , Zheng Songyue 
Published: March 2017

Purpose
The purpose of this study is to enhance the understanding of the role of contracts in channel relationships. Treating contracts as a multidimensional construct, this study examines the effects of contractual issue inclusiveness and contractual obligatoriness on performance and opportunism, as well as the moderating effects of relational norms on the above relationships.

Design/methodology/approach
Based on the data of 206 samples collected from distributors of house furnishing, computer and computer components, moderated regression is used to test the hypotheses.

Findings
The empirical test generally supports the conceptual model and provides three findings. First, contractual issue inclusiveness is more profound in enhancing relationship performance than contractual obligatoriness, and contractual obligatoriness is more statistically powerful in mitigating opportunism than contractual issue inclusiveness. Second, relational norms can enhance the positive effect of contractual issue inclusiveness but not contractual obligatoriness on performance. Third, relational norms can strengthen the negative effect of contractual obligatoriness but not contractual issue inclusiveness on opportunism.

Research limitations/implications
First, this study investigates only contractual issue inclusiveness and contractual obligatoriness, and future studies should consider other dimensions of contracts. Second, the influence of external environment is not considered in the model. Third, data from Chinese distributors limit the generalization of conclusions. Finally, data come only from buyers, and suppliers’ viewpoints are not included.

Practical implications
The results provide a framework for managers to use contracts and relational norms. Managers should pay attention to the alignment between contractual dimensions and firm objectives because various dimensions of contracts have different impacts on channel relationships.

Originality/value
Prior research has documented contracts’ role in coordinating channel relationships but has not achieved consistent conclusions on contracts’ effectiveness. Furthermore, extant research indicates that channel members will use contracts and relational norms simultaneously but has conflicting views on the combined effects of these two control mechanisms. The study contributes by addressing these issues.
An ISM-based approach analyzing interactions among variables of reverse logistics in automobile industries
Authors: Ravi V. , Shankar Ravi 
Published: March 2017

PurposeThis paper aims to analyze the interaction among the major variables of reverse logistics seen in automobile industries.Design/methodology/approachIn this research, interpretive structural modeling (ISM) has been used to understand mutual influences among identified variables of reverse logistics. The advantage of the ISM methodology is that variables can be categorized depending upon their driving power and dependence.FindingsRegulations make it mandatory for automobile companies to own responsibility of products manufactured throughout their life cycle by collecting and reusing products, reducing volume of waste generated, increasing the use of recycled materials, etc. For example, End-of-Life Vehicle Directive had directed manufacturers to take back their vehicles at the end of their usefulness and responsibly dispose them. In this research, regulation has appeared at bottom of the ISM model, indicating that it has high driving power to influence other variables. Also, financial limitations are a significant inhibitor faced by the top management for implementing reverse logistics programs.Research limitations/implicationsThe ISM methodology relies upon expert opinions for developing contextual relation among identified variables. Thus, an expert’s knowledge, his familiarity with industry and its operations may have affected the final results of the ISM model. One of research implications of this study is that variables identified in this ISM model are quite generic, and thus, with marginal adjustments, these can be used in the context of any other supply chain for increasing its productivity and performance.Practical implicationsThe ISM model reveals that regulations affect a significant number of enabler variables of reverse logistics like support of policy entrepreneurs, green purchasing by companies, information and communication technologies that are seen at the upper level of ISM. This indicates that regulations force companies to be proactive towards product recovery actions that lead to initiation of reverse logistics programs by them.Originality/valueThis research has tried to analyze the interaction among the major variables of reverse logistics typically seen in automobile industries which could be useful to logistics managers for taking strategic-level decisions.