bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation of the REINVENT neural network architecture to generate potential HIV-1 entry inhibitors
Authors: Varabyeu D. A. , Karpenko A. D. , Tuzikov A. V. , Andrianov A. M. 
Published: October 2024

Objectives. The main purpose of this work is to adapt the architecture of the REINVENT neural network to generate potential inhibitors of the HIV-1 envelope protein gp120 using in the learning process with reinforcement of molecular docking on GPUs.Methods. To modify the initial network model, molecular docking on GPUs implemented in the learning process with reinforcement was used, and an algorithm was developed that allows converting the representations of connections generated by the SMILES network into the PDBQT format necessary for docking. To accelerate the learning of the neural network in the modified version of the REINVENT model, the AutoDock-Vina-GPU-2.1 docking program was used, and to clarify the results of its work, the procedure for revaluing the affinity of compounds to the target using the RFScore-4 evaluation function was used.Results. Using a modified version of the REINVENT model, more than 60,000 compounds were obtained, of which about 52,000 molecules have a binding energy value to the HIV-1 gp120 protein comparable to the value calculated for the HIV-1 inhibitor NBD-14204, used in calculations as a positive control. Of the 52,000 compounds selected, about 34,000 molecules satisfy the restrictions imposed on a potential drug to ensure its bioavailability when taken orally.Conclusion. The results obtained allow us to demonstrate the effectiveness of an adapted neural network by the example of designing new potential inhibitors of the gp120 HIV-1 protein capable of blocking the CD4- binding site of the gp120 virus envelope protein and preventing its penetration into host cells.
An exploration of the changing understandings of physical impairment and disability in early medieval England: a bioarchaeological, funerary, and historical approach
Authors: Bohling Solange , Croucher Karina , Buckberry Jo 
Published: October 2024

This paper explores experiences and perceptions of physical impairment and disability in early medieval England, contrasting pre-Christian (AD 5th–early 7th centuries) and Christian (AD late 8th–11th centuries) communities through a combination of bioarchaeological, clinical, funerary, historical, and theoretical analyses. By comparing understandings of physical impairment and disability in the pre-Christian and Christian periods, this paper investigates how political rearrangements and the growing power of the Church might have influenced changing contemporary perceptions of physical impairment and disability.
This research has found that the funerary treatment of individuals with physical impairment in the pre-Christian period was extremely variable within and between cemeteries, and there is evidence for arguably positive, normative, and potentially negative burial treatment. Although mortuary treatment of Christian-era individuals with physical impairment was somewhat variable, this variation was much more subtle. This reflects the overall Christian-era pattern in burial form, and strongly negative or positive mortuary treatment was not identified among the individuals with physical impairment. Based on this evidence, it is proposed that administrative and judicial standardisation, conversion to Christianity, and the spread of Christian morals and doctrine influenced the reduction in mortuary variability observed in individuals with physical impairment and/or disability in the 8th–11th centuries in England.
First record of Phoronopsis (Phoronida) from Japan, with a description of Phoronopsis californica Hilton, 1930 from Okinawa
Authors: Hirose Masato , Uyeno Daisuke 
Published: October 2024

Phylum Phoronida currently contains two genera, Phoronis Wright, 1856 and Phoronopsis Gilchrist, 1907, with approximately thirteen speices. Phoronida is distributed worldwide, ranging from northern Europe to southern New Zealand and also from intertidal to 400 m depths. From Japanese waters, four species of Phoronis have been reported, viz. Phoronis ijimai Oka, 1897, Phoronis australis Haswell, 1883, Phoronis psammophila Cori, 1889 and Phoronis emigi Hirose et al., 2014.
We describe the morphology of Phoronopsis californica Hilton, 1930, based on five specimens collected at a sandy-mud habitat in Nago Bay and Oura Bay, Okinawa, Japan. We examined the internal anatomy by serial paraffin sections. We also examined the genetic distance of Japanese specimens from the other phoronid sequences in GenBank. This is the first record of Phoronopsis from Japanese waters and the fifth species record of phoronids in addition to the previously recorded four species of Phoronis.
The family and substance abuser in the mental health institution environment
Authors: Jacobs Ruwayda , Strumpher Johanita 
Published: October 2024

Background: South African drug usage demographics are rare. Substance abuse disorder patients and their families have complex interactions. This study examines family members living with drug addict.Aim: The study seeks to investigate the experiences of family members living with a substance use disorder (SUD) individual.Setting: The research took place in a Gqeberha psychiatric facility. Low-income households were interviewed.Methods: This research is qualitative, exploratory, and descriptive study. Recorded and transcribed in-depth patient family interviews were collected. Qualitative thematic analysis was used to analyse data. The data themes were interpreted using family systems theory.Results: Each of the three main themes has subthemes. The first theme concerns family members’ inadequate comprehension of addiction. The subtheme explores family members’ denial and failure to recognize substance use disease symptoms. The second theme concerns variations in behaviour that challenge cultural norms. This subtheme addresses hallucinations, delusions, and fury in SUD patients. The third theme addresses the negative effects of drug use on families, potentially leading to divorce. This subtheme focuses on the family’s lack of awareness of resources that may have supported them and the SUD individual.Conclusion: Immediate family members are crucial to patient recovery. The family seemed to be struggling living with an SUD relative. Experts should help the family to manage the addict’s treatment. Healthcare education can help families cope with substance abusers.Contribution: This study will assist the nursing administration in discovering ways to help families manage a loved one with an SUD.
Severe Pneumonia and Cytomegalovirus Coinfection in Infants with Human Immunodeficiency Virus Infection
Authors: Tsanglao Wonashi R. , Joshi Maitreyee , Aier Tenukala , Kikon Sulanthung 
Published: October 2024

Summary
Cytomegalovirus (CMV) is known to cause fatal pneumonia in human immunodeficiency virus (HIV) infected children. There is a paucity of literature on pediatric HIV and CMV coinfection in India. We describe six cases of severe pneumonia in infants infected with HIV. Four of these infants also had CMV coinfection, detected by urine polymerase chain reaction. There was a lack of antenatal and postnatal care in all cases. All four infants with CMV coinfection succumbed to severe acute respiratory distress syndrome, whereas the other two survived. In conclusion, a high index of suspicion for CMV should be kept in HIV-infected infants presenting with severe pneumonia, although CMV pneumonia is difficult to diagnose with certainty. The important role of antenatal care for mothers with HIV infection, as well as postnatal care for babies born to HIV-positive mothers, cannot be overstated.
Global Warming and Rising Threat of Dengue Fever: Expectations in Disease Management
Authors: Sinha Swati , De Auley , Halder Ajanta 
Published: October 2024

Summary
Arbovirus-borne dengue fever remains a global public health threat. The actual burden of dengue infection may be underestimated due to undiagnosed or misdiagnosed fever cases. The distribution of dengue is influenced by both climatic and nonclimatic factors, including global warming, which affects the vector population and transmission period. Other factors, such as serotype evolution and host immunity, also contribute to the spread of the virus. Different serotypes of the dengue virus show different clinical manifestations. The prevalence of serotypes varies geographically and over time. Early diagnosis and characterization of circulating viruses at the genomic level are important for disease prevention and control.
Health Perception and Healthy Life Awareness during the COVID-19 Pandemic: Turkey Profile Study
Authors: Yildirim Naci , Ciftci Bahar 
Published: October 2024

Abstract

Background:
The perception of health, which is the combination of personal feelings, thoughts, prejudices, and expectations regarding the individual’s health, is closely related to healthy life awareness.

Objectives:
This research examines the relationship between health perception and healthy life awareness of individuals during the COVID-19 pandemic and the influencing factors.

Materials and Methods:
The study has been carried out in Turkey from July to October 2020. The population of the research is the people who live in Turkey. The sample comprises 1752 participants who met the research criteria and were selected through a stratified sampling method. The study data were collected using the Sociodemographic Characteristics Form, Perception of Health Scale, and Healthy Life Awareness Scale.

Results:
The participants’ mean score from the Perception of Health Scale was 51.67 ± 6.72, and the mean score from the Healthy Life Awareness Scale was 57.84 ± 7.14. A statistically moderate positive correlation was found between the perception of health and healthy life awareness.

Conclusions:
A higher level of perception of health was found in the participants who live in the Marmara region, have postgraduate education, are single, and have more income than their expenses. It was also found that, among the participants, those who live in the Marmara region, aged 29–39, are female, have a postgraduate education, are married, have more income than expenses, and have a higher level of healthy life awareness. It was found that as the health perception of individuals increases, their understanding of healthy life also increases during the COVID-19 pandemic period.
Current Practices in Genetic Testing for Prostate Cancer: The Indian Scenario
Authors: Bakshi Ganesh , Rajappa Senthil , Joshi Amit , Desai Chirag , Addla Sanjai , Baxi Hemang , Talwar Vineet , Mohapatra Prabrajya Narayan , Shingla Shivam , Kulkarni Utkarsha 
Published: October 2024

Abstract

Background:
Despite genetic testing being recommended by international guidelines for the selection of targeted therapy for prostate cancer (PCa), limited data are available on genetic testing for PCa in India.

Objectives:
The objective is to understand the current genetic testing practice pattern for PCa in India.

Materials and Methods:
A panel of 9 experts developed and validated a premeeting online questionnaire comprising 12 objective questions. The questionnaire was circulated from February 2022 to May 2022 among medical oncologists and uro-oncologists across pan-India, followed by response collection over 3 months. Descriptive statistics were used to summarize results and concluding statements were formulated on current genetic testing practice patterns for PCa.

Results:
A total of 103 responses were received. Genetic testing was advised by 35.9% of the participants in <5% of patients with PCa. Patients with a family history of PCa (88.3%) were most commonly referred for genetic testing. Nearly half (50.2%) of the participants routinely tested for homologous recombination repair (HRR) genes; 52% used blood and tissue as the most preferred specimen for performing genetic testing and 44.7% followed the testing sequence of tumor tissue followed by blood. Major barriers to genetic testing were affordability and scarcity of genetic counselors, while a major change could be brought by making it cost-effective and improving access to medication.

Conclusions:
We observed a lower prescription frequency of genetic testing for the HRR gene across pan-India. Improving the quality and access to genetic testing and the availability of cost-effective-targeted therapies will aid in delivering personalized care to patients with metastatic PCa.
Mitigating Intermittent Connectivity Problems in Vehicle-to-Vehicle Communication (V2VC): A Sparse Network Computational Model (SNCM)
Authors: Azameti Adams , Katsriku Ferdinand , Owusu Ebenezer , Abdulai Jamal-Deen 
Published: October 2024

INTRODUCTION: Wireless communication has made remarkable progress, by the rapid development of wireless technology in Artificial Intelligence (AI). Intelligent Transportation Systems (ITS), and Vehicular Ad Hoc Networks (VANETs) have received significant attention to ensure safety. However, V2V communication in VANETs faces uncontrollable challenges due to frequent intermittent connectivity issues in infrastructure-less networks. Addressing these problems in both safety and non-safety applications is a complex task.OBJECTIVES: To mitigate the intermittent connectivity problems, a novel Sparse Network Computational Model (SNCM) was proposed.METHODS: Extensive simulations using MATLAB to analyze the impact of spatial-temporal variations under different traffic flow densities. We varied the sensitivity factor (λ) at different time intervals while maintaining a constant traffic density. RESULTS: The findings indicate that there is no need to increase λ beyond certain thresholds for each level of service. The simulation results provide valuable guidelines for designing sparse networks, effectively mitigating frequent intermittent disconnections. Simulation experiments revealed an optimal threshold for the sensitivity factor λ for each level of service. Increasing λ beyond certain thresholds did not yield significant improvements in mitigating disconnections in V2V communication.CONCLUSION: The results provide valuable insights and guidelines for designing sparse networks to enhance connectivity and address intermittent disconnection issues. This paper presents a groundbreaking endeavor, and therefore, direct comparisons with existing protocols to evaluate its overall performance are beyond the scope of this paper. Instead, the SNCM protocol is intended to set a standard for future researchers to benchmark their research contributions against.
Digital Transformation and Corporate ESG Performance – Evidence from China
Authors: Zhang Wenxin , Li Xiangyu 
Published: October 2024

The focal point of this paper is to study environmental, social, and governance (ESG) performance consequences of digital transformation for companies, as well as green technological innovation, corporate social responsibility, and internal control as mediating variables. A set of digital transformation indicators was developed utilizing data from 355 listed industrial companies in China between 2011 and 2019 and vector arithmetic. The study’s findings suggested that digital transformation has considerably raised ESG performance, with green technological innovation, corporate social responsibility, and internal control as significant mediating variables. The paper has several contributions; for example, it provides theoretical and empirical evidence for ESG improvement in Chinese firms and an essential factor associated with ESG performance, among others. The non-economic impacts of digital transformation on ESG performance are essential insights offered by this study. They also provide insight into these impacts' mechanisms, including green technology, corporate social responsibility, and internal control.

Received: 9 May 2024 | Revised: 5 August 2024 | Accepted: 31 August 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Author Contribution Statement
Wenxin Zhang: Conceptualization, Methodology, Investigation, Resources, Data curation, Writing – original draft. Xiangyu Li: Software, Writing – review & editing.
Structural Analysis Technique and Its Validation for Large Range Mirror Refocusing System for Spaceborne Deployable Telescopes
Authors: Pal Yesh , Dev Rahul , Patel Naimesh R. , Mathur Neeraj , Joshi Shaunak R. , Dod Harshraj 
Published: October 2024

Large aperture deployable telescopes with numerous onboard instruments are popular in the space industry for astronomy. Scientific data in various wavelength bands, from 0.6µ to 28µ, is provided by these instruments and is crucial for deep space exploration. The deployment mechanisms handle the alignment and functionality at the telescope level only. At instrument level, there is always a need for a refocusing system which can cater individual need of instrument for focusing independent to other instruments nearby. In this paper, we present a structural analysis technique for such a type of large range mirror refocusing mechanism, similar to the Near Infrared Spectrograph (NIRSpec) payload of the James Webb Space Telescope (JWST). The method relies on geometric non-linearity for large deflection, in which the structure's stiffness matrix changes as a function of loading. We have designed, analyzed structurally, and tested a 4mm range slider crank based compliant mechanism. The outcomes of linear and non-linear static analysis, computed numerically, have been compared. There are noticeable significant variations in one direction between the two analyses' results. The results are validated using appropriately designed and realized test setups, like measurements of displacement, changes in focus and image position of the optical system.

Received: 21 February 2024 | Revised: 15 May 2024 | Accepted: 1 October 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support the findings of this article cannot be publicly available due to privacy. They can be requested from the corresponding author.

Author Contribution Statement
Yesh Pal: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization, Project administration. Rahul Dev: Conceptualization, Methodology, Validation, Investigation, Resources, Data curation, Writing - review & editing, Visualization, Supervision, Project administration. Naimesh R. Patel: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - review & editing, Visualization, Supervision, Project administration. Neeraj Mathur: Conceptualization, Investigation, Resources, Writing - review & editing, Supervision, Project administration. Shaunak R. Joshi: Conceptualization, Investigation, Resource, Writing - review & editing, Supervision, Project administration. Harshraj Dod: Software, Validation, Formal analysis, Investigation, Writing - original draft, Writing - review & editing.
Benefits and Mode of Action of Various Hasta Mudra
Authors: Dhiman Sonia , Chaudhary Vijay , Jagota Ankush 
Published: October 2024

Introduction: In this modern era, our lifestyle is changed and become sedentary. Lack of physical exercise, faulty dietary habits, increased stress, and environment changes lead to many diseases. Everybody is fed up by taking so many medicines. Hence, people are showing interest in drugless therapies. Practicing Hasta mudra is totally drugless and cost less. Aim: The aim of this article is to describe the preventive and curative benefits of Various Hasta Mudra and to explain the mode of action of Various Hasta Mudra. Materials and Methods: Various benefits and modes of action of Hasta Mudra have been explained on the basis of classical texts and literature. Results: With regular practice of Hasta mudra, various diseases can be prevented and cured. Discussion: Mudra should be performed for at least 45 min in a day. Conclusion: Hasta Mudra is helpful in Mudhra therapy can control stress, depression, anxiety, fear and promotion of mental health and happiness prevention and cure of many diseases. in Mudra.[3] In Shiva Samhita, it is mentioned that just by practicing The word mudra is a Sanskrit word which has the meaning “gesture” or “attitude.” Mudra can be described as emotional, psychic, devotional, and esthetic gestures or attitudes. Mudra are attitudes of energy flow, which help in linking person’s pranic force with universal or cosmic force.[1] The literal meaning of mudra is the expression of internal feelings by way of different postures of fingers, palms, hands feet, and or body. This is an integral part of yoga and a scientific knowledge of spirituality and physical well. There are different types of Mudra, but in this article, we are discussing only about Hasta Mudra. By doing Hasta mudra, subtle hand and finger movements make important connections in the nervous system and stimulate specific energy pathways. In Hatha Yoga, there are 10 mudra which are mentioned as Jaramarananashaka.[2] In Gheranda Samhita, there are 25 Mudra and according to it, various eye and body positions (Asana) and Locks (Bandha) are also included
A Review on Management of Vataja Shirorog W.S.R. to Tension type Headache through Dashmooladi Siddha Ksheerdhara and Oral Administration
Authors: Singh Surabhi , Kumar Ajay , Singhal Tina 
Published: October 2024

It is sad and known to everybody that in today’s era, it is difficult to maintain one’s mental health. A happy mind can accomplish anything but with a busy, competitive, and demanding life, earning bread and butter has deteriorated one’s mindset. Today’s lifestyle change, i.e., irregular food habits, suppression of natural urges, lack of proper sleep, and less time for relaxation, has increased incidences of many diseases. Due to complexity, diversity, and range of root causes of mental health and little awareness about healthy mind among people, it becomes challenging to diagnose the problem. In Ayurveda, mind contemplates to be a bridge between indriyas and indriyarthas. If the mind is unhealthy, it will surely reflect upon the body. Insomnia, insanity, tension-type headache, office headache, depression, schizophrenia, stress, and anxiety have now become very common. Fortunately, in Ayurveda, there are various lines of treatments such as Satva avajaya chikitsa, Daivya vyapasraya chikitsa, Adravyabhoot chikitsa, Yukti vyapasraya chikitsa, Achar rasayan, Yoga, and pranayama followed by proper diet and also Panchakarma therapies such as nasya and shirodhara with medicated oil seems quite effective. Shirodhara can be performed using a variety of herbs including takra, ksheer, kwath, etc. It involves continually and rhythmically pouring liquid over the forehead from a specified height for a set amount of time. The liquid depends on what disease is being treated. Shirodhara also involves a head massage. It is thought to be a good relaxing procedure for mind.