bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity of two corn hybrids to tolpyralate plus reactive oxygen species–generating herbicides
Authors: Soltani Nader , Shropshire Christy , Fluttert John , Sikkema Peter H. 
Published: October 2024

Abstract
Herbicides that inhibit 4-hydroxyphenylpyruvate dioxygenase (HPPD) can be mixed with herbicides that generate reactive oxygen species (ROS) to enhance the spectrum, level, speed, and consistency of weed control efficacy; however, mixtures of these herbicides can increase corn injury. A total of five field trials were conducted from 2021 to 2023 in Ridgetown, Ontario, to determine the sensitivity of two corn hybrids (‘DKC39-97’ and ‘B79N56PWE’) to tolpyralate plus ROS-generating herbicides (atrazine, bromoxynil, bentazon, or glufosinate) applied postemergence at the recommended rate (1×) and sequentially to represent a spray overlap (2×) in the field. Tolpyralate plus atrazine, bromoxynil, bentazon, or glufosinate (2× rates) caused greater corn injury to DKC39-97 than B79N56PWE corn at 1, 2, and 4 wk after treatment (WAT). Tolpyralate plus atrazine, bromoxynil, bentazon, or glufosinate (2× rates) caused 38%, 36%, 29%, and 18% injury to DKC39-97 corn, but only 5%, 20%, 9%, and 2% injury to B79N56PWE corn, respectively at 1 WAT. Corn injury to both hybrids decreased over time with ≤2% injury at 8 WAT. Tolpyralate + atrazine, bromoxynil, or bentazon (2× rates) caused a 17%, 16%, and 13% height reduction, respectively, of DKC39-97 corn at 2 WAT; however, tolpyralate + glufosinate did not reduce DKC39-97 corn height. Tolpyralate + bromoxynil or bentazon (2× rates) caused a 12% and 10% height reduction of B79N56PWE corn, respectively, at 2 WAT; however, tolpyralate + atrazine or glufosinate did not reduce B79N56PWE corn height. Tolpyralate + atrazine or glufosinate (2× rates) caused a greater corn height reduction of DKC39-97 corn than B79N56PWE corn at 2 WAT. Grain yield was on average 2% lower from DKC39-97 than B79N56PWE corn. Tolpyralate + bromoxynil or bentazon (2× rates) caused 7% and 6% corn grain yield reduction compared to tolpyralate plus glufosinate (2× rate). Results indicate that tolpyralate + ROS-generating herbicides can cause corn injury, which is influenced by corn hybrid and ROS-generating herbicide. Corn producers need to consider the differential sensitivity of corn hybrids and ROS-generating herbicides when using an HPPD-inhibiting herbicide for weed management.
Coastal Dune Erosion and Slumping Processes in the Swash‐Dune Collision Regime Based on Field Measurements
Authors: van Wiechen P. P. J. , Mieras R. , Tissier M. F. S. , de Vries S. 
Published: October 2024

AbstractThis paper studies hydrodynamic and morphodynamic field measurements of two storms with dune erosion in the swash‐dune collision regime. It analyses (a) the behavior and change of the total dune profile over the course of both storms (b) the erosion rate at the dune base, (c) the slumping frequency, and (d) the volumes of individual slumps. The erosion rate at the dune base shows a strong positive correlation with the square of the total water levels that were exceeded for 2% of the time, recorded approximately 5–6 m in front of the dune face (r = 0.91). Individual slumping events occurred when nearly all sediments from previous slumps at the dune base were transported away from the dune. A strong positive correlation was found between the time between two consecutive slumps, and the volume of the first slump divided by the mean erosion rate between the two slumps (r = 0.90). As a consequence, smaller slumps were followed more rapidly by a new slump than larger slumps, under identical erosion rates. The majority of the slumping events occurred after the last wave impact before a slumping event, when the instantaneous water level in front of the dune was still retreating. No clear process based on the incident hydrodynamics could be identified that determined the size of individual slumps. Overall, the results of this study suggest that the morphodynamic behavior of the upper dune face and dune crest is primarily steered by the erosion at the dune base.
BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial
Authors: Torr Bethany , Jones Christopher , Kavanaugh Grace , Hamill Monica , Allen Sophie , Choi Subin , Garrett Alice , Valganon-Petrizan Mikel , MacMahon Suzanne , Yuan Lina , Way Rosalind , Harder Helena , Gold Rochelle , Taylor Amy , Gabe Rhian , Lucassen Anneke , Manchanda Ranjit , Fallowfield Lesley , Jenkins Valerie , Gandhi Ashu , Evans D. Gareth , George Angela , Hubank Michael , Kemp Zoe , Bremner Stephen , Turnbull Clare 
Published: October 2024

Abstract
Background
Genetic testing to identify germline high-risk pathogenic variants in breast cancer susceptibility genes is increasingly part of the breast cancer diagnostic pathway. Novel patient-centred pathways may offer opportunity to expand capacity and reduce turnaround time.

Methods
We recruited 1140 women with unselected breast cancer to undergo germline genetic testing through the BRCA-DIRECT pathway (which includes a digital platform, postal saliva sampling and a genetic counsellor telephone helpline). Ahead of consenting to the test, participants were randomised to receive information about genetic testing digitally (569/1140, 49.9%) or via a pre-test genetic counselling consultation (571/1140, 50.1%).

Results
1001 (87.8%) participants progressed to receive their pre-test information and consented to testing. The primary outcome, uptake of genetic testing, was higher amongst participants randomised to receive digital information compared with those randomised to a pre-test genetic counselling consultation (90.8% (95% CI: 88.5% to 93.1%) vs 84.7% (95% CI: 81.8% to 87.6%), p = 0.002, adjusted for participant age and site). Non-inferiority was observed in relation to patient knowledge, anxiety, and satisfaction.

Conclusions
Findings demonstrate that standardised, digital information offers a non-inferior alternative to conventional genetic counselling, and an end-to-end patient-centred, digital pathway (supported by genetic counselling hotline) could feasibly be implemented into breast oncology settings.

Clinical trial registration
The study is registered with, and protocol available on, ClinicalTrials.gov (NCT04842799).
Defining the complex needs of families with rare diseases—the example of telomere biology disorders
Authors: Wilsnack Catherine , Rising Camella J. , Pearce Emily E. , Forbes Shepherd Rowan , Thompson Ashley S. , Majid Alina , Werner-Lin Allison , Savage Sharon A. , Hutson Sadie P. 
Published: October 2024

AbstractFamilies with rare diseases, such as telomere biology disorders (TBDs), may have extensive unmet needs given the heterogeneity, chronicity, and potential severity of illness. TBDs are rare inherited syndromes associated with high risk of bone marrow failure, cancer, pulmonary fibrosis, and other severe, chronic complications. To identify gaps in clinical care, we aimed to ascertain the perceived unmet needs of adults and family caregivers, current or bereaved, of individuals with TBDs. Participants were aged ≥18 years with a self-reported TBD diagnosis and/or ever caregivers to one or more family members with a TBD. Participants completed an online survey (N = 35) and/or an audio-recorded telephone interview (N = 32). We calculated descriptive statistics in SPSS and thematically analyzed interview transcripts. Quantitative and qualitative data were analyzed concurrently. Most participants were aged ≥35 years, female, highly educated, and medically insured. Survey respondents reported numerous unmet needs in psychosocial, medical, financial, and daily activity domains. In interviews, participant descriptions validated and contextualized the salience of these unmet needs. Both qualitative and quantitative data identified critical shortfalls in addressing chronic family distress and specialty care coordination. Adults and caregivers of individuals with TBDs have a high risk of adverse psychosocial sequelae given extensive unmet needs. These findings provide a foundation for understanding the range and extent of gaps in care for families with rare diseases, especially TBDs but that are likely applicable to others. Tailored multi-disciplinary interventions involving patients, families, clinicians, researchers, and patient advocacy communities are required to appropriately address care needs for all rare diseases.
Designing chemical systems for precision deuteration of medicinal building blocks
Authors: Dabbs Jonathan D. , Taylor Caleb C. , Holdren Martin S. , Brewster Sarah E. , Quillin Brian T. , Meng Alvin Q. , Dickie Diane A. , Pate Brooks H. , Harman W. Dean 
Published: October 2024

AbstractMethods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use. To that end, this work explores the regio- and stereoselective deuteration of tetrahydropyridine (THP), which is an attractive target for study due to the wide prevalence of piperidines in drugs. A series of d0–d8 tetrahydropyridine isotopomers were synthesized by the stepwise treatment of a tungsten-complexed pyridinium salt with H−/D− and H+/D+. The resulting decomplexed THP isotopomers and isotopologues were analyzed via molecular rotational resonance (MRR) spectroscopy, a highly sensitive technique that distinguishes isotopomers and isotopologues by their unique moments of inertia. In order to demonstrate the medicinal relevance of this approach, eight unique deuterated isotopologues of erythro-methylphenidate were also prepared.
The genetic landscape of basal ganglia and implications for common brain disorders
Authors: Bahrami Shahram , Nordengen Kaja , Rokicki Jaroslav , Shadrin Alexey A. , Rahman Zillur , Smeland Olav B. , Jaholkowski Piotr P. , Parker Nadine , Parekh Pravesh , O’Connell Kevin S. , Elvsåshagen Torbjørn , Toft Mathias , Djurovic Srdjan , Dale Anders M. , Westlye Lars T. , Kaufmann Tobias , Andreassen Ole A. 
Published: October 2024

AbstractThe basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans. Our multivariate GWAS identified 72 genetic loci associated with basal ganglia volumes with a replication rate of 55.6% at P < 0.05 and 87.5% showed the same direction, revealing a distributed genetic architecture across basal ganglia structures. Of these, 50 loci were novel, including exonic regions of APOE, NBR1 and HLAA. We examined the genetic overlap between basal ganglia volumes and several neurological and psychiatric disorders. The strongest genetic overlap was between basal ganglia and Parkinson’s disease, as supported by robust LD-score regression-based genetic correlations. Mendelian randomization indicated genetic liability to larger striatal volume as potentially causal for Parkinson’s disease, in addition to a suggestive causal effect of greater genetic liability to Alzheimer’s disease on smaller accumbens. Functional analyses implicated neurogenesis, neuron differentiation and development in basal ganglia volumes. These results enhance our understanding of the genetic architecture and molecular associations of basal ganglia structure and their role in brain disorders.
Glucosinolate structural diversity shapes recruitment of a metabolic network of leaf-associated bacteria
Authors: Unger Kerstin , Raza Syed Ali Komail , Mayer Teresa , Reichelt Michael , Stuttmann Johannes , Hielscher Annika , Wittstock Ute , Gershenzon Jonathan , Agler Matthew T. 
Published: October 2024

AbstractHost defenses can have broader ecological roles, but how they shape natural microbiome recruitment is poorly understood. Aliphatic glucosinolates (GLSs) are secondary defense metabolites in Brassicaceae plant leaves. Their genetically defined structure shapes interactions with pests in Arabidopsis thaliana leaves, and here we find that it also shapes bacterial recruitment. In model genotype Col-0, GLSs (mostly 4-methylsulfinylbutyl-GLS) have no clear effect on natural leaf bacterial recruitment. In a genotype from a wild population, however, GLSs (mostly allyl-GLS) enrich specific taxa, mostly Comamonadaceae and Oxalobacteraceae. Consistently, Comamonadaceae are also enriched in wild A. thaliana, and Oxalobacteraceae are enriched from wild plants on allyl-GLS as carbon source, but not on 4-methylsulfinylbutyl-GLS. Recruitment differences between GLS structures most likely arise from bacterial myrosinase specificity. Community recruitment is then defined by metabolic cross-feeding among bacteria. The link of genetically defined metabolites to recruitment could lead to new strategies to shape plant microbiome balance.
Phytochrome-dependent responsiveness to root-derived cytokinins enables coordinated elongation responses to combined light and nitrate cues
Authors: Gautrat Pierre , Buti Sara , Romanowski Andrés , Lammers Michiel , Matton Sanne E. A. , Buijs Guido , Pierik Ronald 
Published: October 2024

AbstractPlants growing at high densities can detect competitors through changes in the composition of light reflected by neighbours. In response to this far-red-enriched light, plants elicit adaptive shade avoidance responses for light capture, but these need to be balanced against other input signals, such as nutrient availability. Here, we investigated how Arabidopsis integrates shade and nitrate signalling. We unveiled that nitrate modulates shade avoidance via a previously unknown shade response pathway that involves root-derived trans-zeatin (tZ) signal and the BEE1 transcription factor as an integrator of light and cytokinin signalling. Under nitrate-sufficient conditions, tZ promotes hypocotyl elongation specifically in the presence of supplemental far-red light. This occurs via PIF transcription factors-dependent inhibition of type-A ARRs cytokinin response inhibitors. Our data thus reveal how plants co-regulate responses to shade cues with root-derived information about nutrient availability, and how they restrict responses to this information to specific light conditions in the shoot.
Normal caloric intake with high-fat diet induces metabolic dysfunction-associated steatotic liver disease and dyslipidemia without obesity in rats
Authors: Szudzik Mateusz , Hutsch Tomasz , Chabowski Dawid , Zajdel Mikołaj , Ufnal Marcin 
Published: October 2024

AbstractExcessive caloric intake and obesity due to high-fat (HFD) and high-disaccharide (HDD) diets have been recognized as major contributing factors to dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effect of HFD and HDD without excessive caloric intake is obscure. The aim of the study was to evaluate the effect of physiological caloric intake delivered through HFD and HDD on liver and lipid profiles. The study was performed on 6-week-old male and female (50/50%) Sprague Dawley rats, receiving either a standard (controls, n = 16), HFD (n = 14) or HDD (n = 14) chow. All groups received the same, standard daily calorie rations, titrated weekly to the age of growing rats, for 12 weeks. A panel of metabolic in vivo measurement were performed, followed by histological, biochemical and molecular biology assays on tissues harvested from sacrificed rats. There was no significant difference between the groups in body weight. In contrast to controls, HFD and HDD groups showed metabolic dysfunction-associated steatohepatitis (MASH) characterized by liver steatosis, inflammation, ballooning of hepatocytes and fibrosis. These changes were more pronounced in the HFD than in the HDD group. The HFD group showed significantly higher serum LDL than controls or HDD rats. Furthermore, the HFD group had higher liver protein levels of low-density lipoprotein receptor (LDLR) but lower plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) than the controls or HDD group. There were no differences between sexes in evaluated parameters. The excessive caloric intake and obesity are not prerequisites for the development of MASH and dyslipidemia in rats. The liver changes induced by the HFD and HDD diets exhibit differences in severity, as well as in the expression patterns of LDLR and PCSK9. Notably, these effects are independent of the sex of the rats.
Recent advances in tailoring the microenvironment of Pd-based catalysts for enhancing the performance in the direct synthesis of hydrogen peroxide
Authors: Zhang Ying , Wang Xilun , Wang Ziyue , Liu Liyang , He Xiaohui , Ji Hongbing 
Published: October 2024

The direct synthesis of H2O2 (DSHP) is considered a promising process to replace anthraquinone method. In this review, we discussed the recent advances in tuning the microenvironment for enhancing DSHP performance and pointed out the challenges.
Design, analysis, and optimization of PMSM for ultra-deep water pile hammer application
Authors: Tan Liping , Wang Yucong , Wang Teng , Li Changjiang , Miao Fenghua , Xiao Wensheng , Cui Junguo , Wang Hongyan 
Published: October 2024

With the development of global deepwater oil and gas and offshore wind power resources, there is an increasing demand for ultra-deep water pile hammers (UDPH). In this paper, a permanent magnet synchronous motor (PMSM) with oil fill is proposed for UDPH on the basis of underwater 2500 m depth and 450 kJ impact energy requirements. First, the rated parameters of the PMSM are calculated based on the power required by hydraulic pumps, and then, the method of combining empirical formulas and path algorithms is used to complete the electromagnetic scheme design. Second, finite element analysis of the electromagnetic field is carried out by Maxwell under both no-load and load conditions to verify the rationality of the PMSM. Furthermore, aiming at improving efficiency and reducing cogging, parameter optimization is carried out by a robust parameter optimization design method, and the optimal parameter scheme of the PMSM is obtained. In addition, loss analysis and temperature field coupling calculations of the optimized PMSM are conducted to verify that the temperature of this motor can meet the requirements under different working conditions. Finally, a comparative analysis is conducted between the proposed PMSM and the three-phase asynchronous motor used in the underwater 2,500 m-450 kJ UDPH. The results indicate that the new PMSM introduced in this paper demonstrates significant advantages in terms of weight, volume, and efficiency; moreover, the new PMSM is reasonable and more suitable for UDPH. Therefore, the PMSM proposed in this paper is reasonable and can provide a theoretical basis for improving the traditional UDPH.
Monolithic top emitting room temperature THz DFG QCL with index grating for wavelength selection
Authors: Schmeiduch Hannes , Demmerle Frederic , Oberhausen Wolfhard 
Published: October 2024

We present a high performance top emitting room temperature monolithic terahertz (THz) quantum cascade laser based on difference frequency generation (DFG) and a buried modulated distributed feedback grating. Using a semi-insulating InP:Fe substrate combined with an index-coupled grating could minimize the internal losses for the THz mode. The laser consists of two separate transversely superimposed gratings. The first grating provides selective feedback for the mid-infrared pump modes and is realized in an index-coupled DFG grating designed for single-mode operation for two distinct MIR wavelengths. The second metallic grating for THz extraction is carefully aligned to the spatial distribution of the MIR modes. The resulting device lases pulses up to 150 °C in the single mode. The maximum THz output power at RT is 100 μW measured at 3.37 THz. A THz wavelength tuning of around 0.065 nm/K was achieved through thermal tuning of the MIR pump lasers.
Advanced setup for in situ positron annihilation lifetime measurements under variable gas atmospheres and humidity: From cryogenic to high temperatures
Authors: Attallah Ahmed G. , Hirschmann Eric , Butterling Maik , Hartmann Andreas , Stach Daniel , Findeisen Stefan , Bon Volodymyr , Kaskel Stefan , Wagner Andreas 
Published: October 2024

We present a newly developed instrument for 22Na-based positron-annihilation lifetime spectroscopy, designed to facilitate the simultaneous control of temperature, gas atmosphere, and humidity in a single experimental system. The spectrometer operates within a temperature range of 50–480 K and pressures from 10−6 mbar to 1.5 bars. It features a novel gas dosing chamber that allows in situ adsorption studies with gases such as but not limited to CO2, N2, Ar, O2, and their mixtures, with precise control over mixing ratios. Additionally, the device supports in situ humidity exposure, allowing for comprehensive studies of sample interactions with both humidity and humid gases. Fully automated, the system provides seamless data acquisition and environmental control, including pressure and temperature regulation. We demonstrate the instrument’s capability to elucidate alterations in the free volume of maltodextrin under humidity exposure. Additionally, we illustrate the instrument’s efficacy through case studies on CPO-27 metal-organic frameworks (MOFs), highlighting its versatility in analyzing adsorption phenomena across diverse gas adsorbates and temperatures. This state-of-the-art spectrometer stands as an indispensable tool for probing the physicochemical attributes of materials under varying conditions, providing pivotal insights into gas adsorption mechanisms and material dynamics.
Stability and cavitation of nanobubble: Insights from large-scale atomistic molecular dynamics simulations
Authors: Man Viet Hoang , Li Mai Suan , Derreumaux Philippe , Nguyen Phuong H. 
Published: October 2024

We perform large-scale atomistic simulations of a system containing 12 × 106 atoms, comprising an oxygen gas-filled bubble immersed in water, to understand the stability and cavitation induced by ultrasound. First, we propose a method to construct a bubble/water system. For a given bubble radius, the pressure inside the bubble is estimated using the Young–Laplace equation. Then, this pressure is used as a reference for a constant temperature, constant pressure simulation of an oxygen system, enabling us to extract a sphere of oxygen gas and place it into a cavity within an equilibrated water box. This ensures that the Young–Laplace equation is satisfied and the bubble is stable in water. Second, this stable bubble is used for ultrasound-induced cavitation simulations. We demonstrate that under weak ultrasound excitation, the bubble undergoes stable cavitation, revealing various fluid velocity patterns, including the first-order velocity field and microstreaming. These fluid patterns emerge around the bubble on a nanometer scale within a few nanoseconds, a phenomenon challenging to observe experimentally. With stronger ultrasound intensities, the bubble expands significantly and then collapses violently. The gas core of the collapsed bubble, measuring 3–4 nm, exhibits starfish shapes with temperatures around 1500 K and pressures around 6000 bar. The simulation results are compared with those from Rayleigh–Plesset equation modeling, showing good agreement. Our simulations provide insights into the stability and cavitation of nanosized bubbles.