bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practices and views about palliative care at the end of life: A survey of oncologists from the Italian region of Liguria
Authors: Giannubilo Irene , Battistuzzi Linda , Ruelle Tommaso , Poggio Francesca Benedetta , Buzzatti Giulia , D’Alonzo Alessia , Della Rovere Federica , Molinelli Chiara , Razeti Maria Grazia , Nardin Simone , Arecco Luca , Perachino Marta , Favero Diletta , Borea Roberto , Pronzato Paolo , Del Mastro Lucia , Vecchio Stefania , Bighin Claudia 
Published: October 2024

Introduction: We conducted an online survey to investigate oncologists' clinical practices and views on palliative care at the end of life in the Italian region of Liguria. Methods: The survey included 29 items divided into three sections: participant characteristics (n=6), hospital resources and practices (n=11), participant practices and views (n=12). Results: Twenty-one of the 41 medical oncologists invited completed the survey (51%). Although almost all reported the presence of palliative medicine physicians at their hospitals (90%), nearly half (48%) stated that palliative medicine physicians were not responsible for managing cancer patients at end of life, and 21% reported routine participation of palliative medicine physicians in multidisciplinary meetings. Thirty-eight percent of the respondents stated they never consulted psychologists regarding end of life patient care, and 43% reported they rarely did. Notably, a substantial proportion of participants stated that they administered active treatments to patients with six months life expectancy. Regarding integration between oncology and palliative medicine, an equal proportion felt it had been fully (48%) or partially achieved (48%) at their hospitals. Conclusions: Participants seemed fairly satisfied with the level of integration between oncology and palliative medicine at their hospitals, which contrasts with other findings regarding, for instance, the scant participation of palliative medicine physicians in multidisciplinary meetings. Exploring the impact of the novel regional clinical healthcare pathway for palliative care on practices at hospitals in Liguria will be crucial to ensure that cancer patients at end of life receive quality care.
Impact of statins on incidence of gastrointestinal bleeding events among patients with continuous-flow left ventricular assist devices
Authors: Halawi Hala , Harris Jesse E , Nguyen Duc T , Graviss Edward A , Putney David , Kassi Mahwash 
Published: October 2024

Background: Patients with continuous flow left ventricular assist devices (CF-LVADs) are at increased risk of gastrointestinal bleeding (GIB). Statins are commonly prescribed in LVAD patients for cardiovascular disease prevention. However, their impact on GIB events is controversial. Importantly, literature regarding statins impact on GIB in CF-LVAD patients is lacking. Methods: A single-center, retrospective review of adult patients who underwent CF-LVAD implantation between May 2016 and January 2020 was performed. Patients were categorized based on statin use throughout the study period. The primary outcome was the composite of arteriovenous malformation confirmed GIB and major GIB events for up to 1-year post-LVAD implantation. Results: Of 123 patients included in the final analysis, 66 (54%) received statin therapy during the study period. No difference was observed in the primary outcome between the statin and control groups (RR: 1.73; 95% CI: 0.75–3.98; p=0.20). Multivariable Cox regression revealed that older age and higher baseline creatinine were associated with an increased risk of GIB within 1-year of CF-LVAD implantation. Conclusion: Among patients with CF-LVADs, there was no significant difference in the incidence of major GIB events associated with the use of statin therapy. Further studies are needed to assess whether a true association exists.
An Evaluation of the Mindless to Mindful (M2M) Intervention on Exercise Self-Regulation and Fat Mass Loss: A Case Study
Authors: Kawahata David , Biber Duke 
Published: October 2024

Purpose To evaluate the impact of the Mindless to Mindful intervention on fat mass loss in adults. Design This was a single-group case study. Setting A fitness center delivered by certified fitness professionals. Subjects 222 adults who participated in M2M as a team or as individuals, and 195 completed the entire intervention (attrition rate = 12.16%). Intervention M2M was an 8-week behavior change intervention with tailored coaching, group moderate-to-vigorous exercise (MVE) and self-regulation techniques. Measures Participants completed a demographic questionnaire, the Jackson-Pollock 4-site body fat measure, brief self-control scale, self-compassion scale, and a daily exercise log. Analysis Paired sample t-tests were used to determine differences within groups and a one-way ANOVA was used to determine the differences between groups ( P-value <.05). Results Participants engaged in an average of 4.88 h ( SD = 2.04) of MVE per week. There was a significant decrease in fat mass ( M = £7.65; P < .001) and increase in self-control ( t = 6.248, P < .001, d = .300) and self-compassion ( t = 4.314, P < .001, d = .165). Conclusion Self-monitoring, group exercise, and individualized coaching can promote self-regulation and fat mass loss.
Does high body mass index affect short-term clinical and radiologic outcomes in robotic-assisted total knee arthroplasty?
Authors: Li MingYang , Zhang Han , Zhu HaoXiang , Zhang YongTao 
Published: October 2024

Background The purpose of this study was to determine whether high BMI affect short-term clinical and radiologic outcomes of robotic-assisted total knee arthroplasty (TKA) by comparing the clinical outcomes, radiologic outcomes and complications between high BMI and normal patients. Methods We retrospectively compared the short-term clinical and radiological outcomes of 424 knees (408 patients). The patients were divided into four groups: BMI < 24.9 kg/m2 (normal); BMI between 25.0 and 29.9 kg/m2 (overweight); BMI between 30.0 and 34.9 kg/m2 (obese class I) and BMI between 35.0 and 39.9 kg/m2 (obese class II). Clinical and radiologic outcomes were evaluated. Results There was no significant difference in radiologic outcomes between those groups ( p > .05). Furthermore, there was no significant difference in operation time, drainage volume, fall in hemoglobin, post-operative CRP and complications, including periprosthetic fracture and periprosthetic joint infection (PJI), between those groups. Conclusion High BMI does not affect short-term clinical and radiologic outcomes in robot-assisted TKA.
Considering the Environmental Impact of Cleft Lip and Palate Surgery
Authors: Keating Muireann , de Blacam Catherine 
Published: October 2024

Objective We sought to calculate the waste generated by cleft lip and palate (CL/P) procedures and to increase awareness of the environmental impact of our speciality. Design Waste from 5 CL/P procedures was categorised into 5 streams and weighed. A carbon calculator tool was used to convert weight of waste in to estimated carbon emission over a 12-month period. Setting The study was carried out in a university teaching hospital. Patients and Participants This was an assessment of the waste produced from 5 paediatric CL/P procedures. Main Outcome Measures Weight of waste produced as result of CL/P procedures, measured in kilograms (kg); weight of CO2, measured in kg. Results We found that 768.5 kg of surgical waste was generated by CL/P procedures at our centre annually. This equates to 2653 kg of CO2. Conclusions This study serves as a reminder of surgeons’ responsibility to oversee how the waste we produce is disposed of.
Causality Between ADHD, ASD, and CVDs: A Two-Step, Two-Sample Mendelian Randomization Investigation
Authors: Zheng Zequn , Cai Dihui 
Published: October 2024

Background: While observational studies have established a connection between attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and heightened risk for cardiovascular diseases (CVD), the causal relationships are not well-defined. This study is designed to examine the causality between ASD, ADHD, and CVD risk as well as investigate the mediating factors through which ADHD and ASD influence CVD. Methods and Results: Leveraging two-sample Mendelian randomization (MR) approaches and large scale GWAS summary stats, we examined underlying causal links between ASD and ADHD and the risk of CVDs. The analysis indicated that ADHD was related to an increased likelihood of developing coronary heart disease (OR [95% CI] 1.12 [1.03, 1.21], p = .008), heart failure (OR [95% CI] 1.14 [1.07, 1.22], p = 1.45 × 10−4), and large-artery stroke (OR [95% CI] 1.35 [1.09, 1.66], p = .005). In parallel, ASD showed a correlation with a greater atrial fibrillation risk (OR [95% CI] 1.09 [1.03, 1.16], p = .005] and heart failure (OR [95% CI] 1.11 [1.04, 1.19], p = .004). Additionally, we explored the mediating role of CVD risk factors through two-step MR and multivariable MR, highlighting the possible role of smoking, prescription opioid use, triglycerides, education, income, Townsend deprivation index, and obesity in the causal association of ADHD, ASD, on CVDs. Conclusion: This MR study highlights the necessity for rigorous cardiovascular surveillance and interventions to decrease adverse cardiovascular events in people with ADHD or ASD by preventing identified mediating risk factors.
Adolescent-Reported Changes in Provider Behavior Following Pediatrician Training in Stimulant Diversion Prevention: Results From a Cluster Randomized Controlled Trial
Authors: Molina Brooke S. G. , Joseph Heather M. , Kipp Heidi L. , Pedersen Sarah L. , Kolko David J. , Lindstrom Rachel A. , Bauer Daniel J. , Subramaniam Geetha A. 
Published: October 2024

Objective: To test whether pediatrician training leads to provider utilization of stimulant diversion prevention strategies as reported by adolescent patients with ADHD. Methods: Pediatric practices received a stimulant diversion prevention workshop (SDP) or continued treatment-as-usual (TAU) in a cluster-randomized controlled trial. Surveys were completed by 341 stimulant-treated patients at baseline and three follow-up assessments. Results: In intent-to-treat analyses of patient reports, SDP adolescents reported more provider use of diversion prevention strategies compared to TAU. They also reported more parent-patient communication about diversion. Provider satisfaction with the training was strong. Conclusions: Pediatricians can make use of clinical practice strategies for the prevention of stimulant diversion following a 1-hr training; findings are novel given their reliance on confidential patient report of provider behavior and increase confidence in the results. Coupled with the positive provider satisfaction ratings, results suggest that this brief workshop may be an option for concerned providers that also has the effect of increasing discussion at home about safe use of stimulants.
Evaluation of postoperative outcomes after cataract surgery in patients with Juvenile Idiopathic Arthritis-Associated Uveitis
Authors: Bajraktari Gentian , Jukić Tomislav , Kalauz Miro , Oroz Martin , Bertetić Andrea Radolović , Vukojević Nenad 
Published: October 2024

Purpose To evaluate the postoperative outcomes of cataract surgery and intraocular lens (IOL) implantation on visual outcomes and complications in pediatric patients with Juvenile Idiopathic Arthritis-Associated Uveitis. Methods This study included 25 patients (30 eyes) with uveitis and cataracts who underwent cataract surgery. The study was conducted as a retrospective study. Patients were divided into two groups based on their preoperative treatment: those who received immunomodulatory therapy (IMT) along with systemic corticosteroids and those who received IMT in combination with a biologic therapy. Best corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), macular volume (MV), and postoperative complications were assessed at various time points up to 12 months. All surgeries were performed by a single surgeon. Results Significant improvement in BCVA were observed postoperatively in both study groups, with approximately 80% of eyes showing improvement. Mean BCVA improved from 0.89 ± 0.63 to 0.37 ± 0.33 in group 1and from 0.82 ± 0.68 to 0.35 ± 0.31 in group 2 after 12 months. Postoperatively, there was a decrease in mean IOP, with no significant variance observed between the two groups. Complications were observed in 73% of cases, including posterior capsular opacification (PCO), secondary glaucoma, and macular edema (ME), but did not significantly differ between groups. Conclusion Cataract surgery in children with uveitis associated with JIA presents significant challenges due to the risk of postoperative complications, even with adequate preoperative and postoperative care. The similar improvement in BCVA observed in both groups suggests that different systemic therapies were sufficient for satisfactory control of inflammation before and after surgery.
Refining delivery and positioning: A modified approach to FIL SSF intraocular lens implantation using the “full reverse” technique
Authors: Chisci Enea , Torregrossa Giulia , Torregrossa Salvatore , Mantia Alberto La 
Published: October 2024

Purpose To present a modified surgical technique for implantation of the sutureless scleral-fixated hydrophilic intraocular lens (FIL SSF). Methods Single surgeon retrospective case series and review of surgical videos with step-by-step technique analysis. Uncorrected and best corrected visual acuity (UCVA and BCVA), refractive error (spherical equivalent), full clinical examination with intraocular pressure (IOP) measurement, endothelial cell density on corneal specular microscopy and macular optical coherence tomography (OCT) were recorded at baseline, 1, 4 and 8 weeks postoperatively. Results The FIL SSF IOLs were successfully implanted using the so-called “full reverse” technique, having the lens loaded in the injector in an upside-down fashion, as opposed to IOL technical specifications. In all cases, the FIL SSF IOL was properly placed in the ciliary sulcus, well-centered and without signs of tilt. Follow up figures at 2 months are consistent with published data, confirming the potential benefits of the new implantation technique. Conclusion In our preliminary experience, the “full reverse” technique of the FIL SSF IOL has proven effective in preventing incorrect IOL orientation in 100% of cases. However, larger prospective controlled studies and longer follow up are required to either support or disprove our results.
A qualitative study of factors influencing evidence-based practice of blood collection by clinical nurses via central venous access devices
Authors: Qian Yan , Shen Wangqin , Qin Yi , Jin Xiaohong , Hu Feihong 
Published: October 2024

Background: Several studies have upheld the advantages of blood collection using via central venous access device (CVAD); the procedure has a high success rate and avoids painful repeated punctures. Some studies have suggested that via central venous access device (CVAD) blood collection is preferable for acute and critical care, oncology, and pediatric patients. However, there is no consensus on or standardization of this approach. Purpose: To explore the facilitators of and barriers factors of evidence-based decision-making in CVAD blood collection in clinical practice. Methods: This was a qualitative study guided by phenomenological research. A purposive sampling method was used to select 13 clinical nurses from two public hospitals in China to conduct semi-structured personal interviews. The interview outline was designed based on a literature review and the i-PARIHS theoretical framework, and information was organized and analyzed using the Colaizzi 7-step analysis method. Results: Two themes and seven sub-themes were derived from the analysis of interview data. Facilitating factors: (1) nurses’ trust the evidence-based nursing decisions; (2) low rate of operational complications; (3) high success rate of blood collection; (4) nurses’ sense of professional benefit; Hindering factors: (1) preparation of operational materials and time-consuming operation; (2) nursing interruptions; (3) patients’ economic factors. The interview data showed that CVAD blood collection is suitable for critically ill patients, children, patients with poor venous conditions and poor cooperation. Conclusion: This study provides guidance for advancing the clinical application of evidence-based CVAD blood collection. Evidence-based nursing culture, operational advantages, and nurses’ sense of professional benefit were effective facilitators of the evidence-based practice. Researchers need to optimize the operating materials and methods, and comprehensively consider multiple factors to promote the better application of evidence.
Real-World Data Presenting the Descriptive Analysis of the Use of Tyrosine Kinase Inhibitors (TKIs) Among Metastatic Non–Small-Cell Lung Cancer (mNSCLC) Patients in Qatar: A Nationwide Retrospective Cohort Study
Authors: Dawoud Rawan , Saman Harman , Rasul Kakil , Jibril Farah , Sahal Arwa , Al-Okka Randa , Mahfouz Yaser , Omar Nabil E. , Hamad Anas , Mohsen Reyad , Kanbour Aladdin , Battikh Naim , Chandra Prem , Elazzazy Shereen 
Published: October 2024

Background: There has been significant improvement in treating metastatic non–small-cell lung cancer (mNSCLC) over the past 2 decades. The aim of this study is to describe the use of tyrosine kinase inhibitors (TKIs) in Qatar. This study focuses on the objective response rate (ORR) and reported adverse drug events (ADEs) of TKIs used for the management of patients with mNSCLC. Methods: This is a descriptive retrospective cohort study. All non–small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutations who received TKIs between 2015 and 2019 in Qatar were included. The TKIs used during this period include EGFR inhibitors such as afatinib, erlotinib, gefitinib, and osimertinib and ALK inhibitors such as alectinib and crizotinib. The response on each TKI was identified by reporting the ORR (as the sum of the complete response [CR] and the partial response [PR]), in addition stable disease (SD) and disease progression (DP) were reported. While ADEs were reported using the National Cancer Institute’s Common Terminology Criteria for Adverse Events (NCI-CTCAE). Results: A total of 63 patients were included, of which 36 cases (57.1%) expressed EGFR mutation, and 27 patients (42.9%) expressed ALK rearrangement. The ORR in EGFR inhibitors was as follows: osimertinib 40%, gefitinib 33%, afatinib 22%, and erlotinib 18%. However, the response to the ALK-targeted therapy was 43% with alectinib and 40% with crizotinib. A total of 112 ADEs were reported. They were distributed as 63.4% (71 of 112) with the anti-EGFR and 36.6% (41 of 112) ADEs with the ALK inhibitors. In the anti-EGFR group, the most common types of ADEs were dermatological toxicity 30%, whereas, in the anti-ALK group, gastrointestinal toxicity was the most common (29%). Conclusions: The EGFR-targeted and ALK-targeted therapies appear to have acceptable clinical response rate and safety profile in our population. Close and frequent monitoring of adverse events is advised to ensure a good quality of life and prevent serious complications.
Ramosetron 3.0 μg/mL Combining with Dexamethasone (0.05, 0.1, 0.2 mg/mL) in Infusion Solutions: A Physicochemical Stability Study
Authors: Fang Baoxia , Zhao Lijun , Yu Shirong , Chen Fuchao 
Published: October 2024

Background Dexamethasone in conjunction with type 3 serotonin receptor antagonists are being used to the prevention and treatment of chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting in clinic. The present study aimed to investigates the stability of ramosetron with dexamethasone in infusions, with the goal of enhancing the safety and clinical applicability of their combined use. Methods Ramosetron hydrochloride (3.0 μg/mL) combining with dexamethasone (0.05, 0.1, 0.2 mg/mL) were prepared with 0.9% sodium chloride injection and then packaged in polyolefin bags or glass bottles. The stability were investigated kept in the dark at refrigeration for 14 days and at room temperature for 48 h. Results The concentration of both drugs maintained at least 97% in the various solutions for both storage conditions with light protection. In the light exposure conditions, as the extension of storage time, the concentration of both drugs had declined. All antiemetic mixture solutions remained clear and no changes in color, turbidity, precipitation, and the pH remained stable. The insoluble particles were in line with Chinese Pharmacopoeia. Conclusion Our findings suggest that combinations of ramosetron hydrochloride with dexamethasone sodium phosphate in 0.9% sodium chloride injection remain stable for 14 days at 4°C and 48 h at 25°C when protected from light.
Podcasts as a tool for promoting health-related behaviours: A scoping review
Authors: Robins Bethany , Delaney Tessa , Maher Carol , Singh Ben 
Published: October 2024

Background Podcasts are a popular medium for delivering health-related content, potentially influencing physical and mental health behaviours and outcomes. This scoping review evaluates the impact of health podcasts on such outcomes, engagement levels, and public perceptions. Methods This scoping review followed the Arksey and O'Malley framework and PRISMA-ScR guidelines. Qualitative or quantitative articles published from 2004 onward were included. Eligibility criteria were developed using the Population, Exposure and Outcome framework. Included articles examined the use, engagement with, or perspectives towards health-related podcasts. Data were synthesised narratively. Results Fifty articles encompassing 38 studies were analysed. Significant improvements ( p < 0.05) were observed in health monitoring, knowledge, behaviours, attitudes, chronic disease management, maternal health and behavioural improvements. Results were mixed for physical activity ( n = 2 significantly improved, n = 2 no change), fruit and vegetable consumption ( n = 1 significantly improved, n = 1 no change), and weight outcomes ( n = 2 significantly improved, n = 2 no change). No significant changes were observed in depression and anxiety. Podcast engagement studies ( n = 7) reported participation rates between 62% and 83% and an average weekly listening duration of 103–124 minutes. There was high satisfaction, trust and appreciation for podcasts that effectively blended personal anecdotes with reliable medical information. Sample sizes ranged from 7 to 722, with sample age ranging from under 18 to 73.2 ± 6.2 years. Studies included both male ( n = 1), female ( n = 6) and mixed samples ( n = 24). Podcasts were used individually ( n = 19), alongside other supportive technology such as apps and online material ( n = 11) and retrospective podcast use was analysed in cross-sectional ( n = 3) and a single ( n = 1) audit. Duration of podcasts ranged from 30 seconds to 24 minutes. Conclusion Podcasts show promise as effective tools for health promotion, achieving strong engagement and effects on knowledge and behaviours. Future research should explore content innovation and integration into health interventions, and long-term effectiveness.