bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico analysis of single nucleotide polymorphisms (SNPs) in human FOXC2 gene
Authors: Nimir Mohammed , Abdelrahim Mohanad , Abdelrahim Mohamed , Abdalla Mahil , Ahmed Wala eldin , Abdullah Muhanned , Hamid Muzamil Mahdi Abdel 
Published: October 2017

Introduction: Lymphedema is an abnormal accumulation of interstitial fluid, due to inefficient uptake and reduced flow, leading to swelling and disability, mostly in the extremities. Hereditary lymphedema usually occurs as an autosomal dominant trait with allelic heterogeneity.Methods: We identified single nucleotide polymorphisms (SNPs) in the FOXC2 gene using dbSNP, analyzed their effect on the resulting protein using VEP and Biomart, modelled the resulting protein using Project HOPE, identified gene – gene interactions using GeneMANIA and predicted miRNAs affected and the resulting effects of SNPs in the 5’ and 3’ regions using PolymiRTS.Results: We identified 473 SNPs - 429 were nsSNPs and 44 SNPs were in the 5’ and 3’ UTRs. In total, 2 SNPs - rs121909106 and rs121909107 - have deleterious effects on the resulting protein, and a 3D model confirmed those effects. The gene – gene interaction network showed the involvement of FOXC2 protein in the development of the lymphatic system. hsa-miR-6886-5p, hsa-miRS-6886-5p, hsa-miR-6720-3p, which were affected by the SNPs rs201118690, rs6413505, rs201914560, respectively, were the most important miRNAs affected, due to their high conservation score.Conclusions: rs121909106 and rs121909107 were predicted to have the most harmful effects, while hsa-miR-6886-5p, hsa-miR-6886-5p and hsa-miR-6720-3p were predicted to be the most important miRNAs affected. Computational biology tools have advantages and disadvantages, and the results they provide are predictions that require confirmation using methods such as functional studies.
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response
Authors: Chalmers Fiona , van Lith Marcel , Sweeney Bernadette , Cain Katharine , Bulleid Neil J. 
Published: October 2017

Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR). This stress response results in expansion of the ER, upregulation of proteins involved in protein folding and degradation, and attenuation of protein synthesis. The response is orchestrated by three signalling pathways each activated by a specific signal transducer, either inositol requiring enzyme α (IRE1α), double-stranded RNA-activated protein kinase-like ER kinase (PERK) or activating transcription factor 6 (ATF6). Activation of IRE1α results in its oligomerisation, autophosphorylation and stimulation of its ribonuclease activity. The ribonuclease initiates the splicing of an intron from mRNA encoding the transcription factor, X-box binding protein 1 (XBP1), as well as degradation of specific mRNAs and microRNAs. Methods: To investigate the consequence of expression of exogenous XBP1, we generated a stable cell-line expressing spliced XBP1 mRNA under the control of an inducible promotor. Results: Following induction of expression, high levels of XBP1 protein were detected, which allowed upregulation of target genes in the absence of induction of the UPR. Remarkably under stress conditions, the expression of exogenous XBP1 repressed splicing of endogenous XBP1 mRNA without repressing the activation of PERK. Conclusions: These results illustrate that a feedback mechanism exists to attenuate Ire1α ribonuclease activity in the presence of XBP1.
Correlation of near-Earth proton enhancements >100 MeV with parameters of solar microwave bursts
Authors: Гречнев Виктор , Grechnev Victor , Киселев Валентин , Kiselev Valentin , Мешалкина Наталия , Meshalkina Nataliya , Черток Илья , Chertok Ilya 
Published: October 2017

We analyze the relations between various combinations of peak fluxes and fluences of solar microwave bursts at 35 GHz recorded with the Nobeyama Radio Polarimeters during 1990–2015, and corresponding parameters of proton enhancements with E>100 MeV exceeding 0.1 pfu registered by GOES monitors in near-Earth environment. The highest correlation has been found between the microwave and proton fluences. This fact reflects a dependence of the total number of protons on the total duration of the acceleration process. In the events with strong flares, the correlation coefficients of proton fluences with microwave and soft X-ray
fluences are higher than those with speeds of coronal mass ejections. The results indicate a statistically larger contribution of flare processes to acceleration of high-energy protons. Acceleration by shock waves seems to be less important at high energies in events associated with strong flares, although its contribution probably prevails in weaker events. The probability of a detectable proton enhancement was found to directly depend on the peak flux and duration of a microwave burst. This can be used for diagnostics of proton enhancements based on microwave observations.
Efficient Simulation of Clustering Jumps with CIR Intensity
Authors: Dassios Angelos , Zhao Hongbiao 
Published: October 2017

We introduce a broad family of generalised self-exciting point processes with CIR-type intensities, and we develop associated algorithms for their exact simulation. The underlying models are extensions of the classical Hawkes process, which already has numerous applications in modelling the arrival of events with clustering or contagion effect in finance, economics, and many other fields. Interestingly, we find that the CIR-type intensity, together with its point process, can be sequentially decomposed into simple random variables, which immediately leads to a very efficient simulation scheme. Our algorithms are also pretty accurate and flexible. They can be easily extended to further incorporate externally excited jumps, or, to a multidimensional framework. Some typical numerical examples and comparisons with other well-known schemes are reported in detail. In addition, a simple application for modelling a portfolio loss process is presented.The online appendix is available at https://doi.org/10.1287/opre.2017.1640
MENAKAR TRADISI KAWIN PAKSA DI MADURA DENGAN BAROMETER HAM
Authors: Sa’dan Masthuriyah 
Published: October 2017

There is a tradition of forced marriage (kawin/nikah paksa) in Madurese society in which young females are paired up with and married off to young males of their parents choosing. Young women may be promised in marriage when they are still in their mothers’ wombs or in childhood, and the marriage age for girls is generally under the age of 18 years, though there are those who marry between 12-15 years. Regeneration of the ancestral lineage can be seen in several areas in Madura including Bangkalan, Sampang, Pamekasan and Sumenep. Instead of the following the prescriptions of Muhammad, girl children have become ‘victims’ of a culture that discriminates against them. If seen from a human rights perspective, the tradition of kawin paksa breaches the ethics related to humanity, justice and equality.
CONFIRMING DOMESTIC IDENTITY, SUPPORTING PUBLIC COMMITMENT (The Case of Tuan Guru’s Wife in Lombok West Nusa Tenggara Eastern Indonesia)
Authors: Wardatun Atun , Amrullah Asyiq , Musta’in Mr 
Published: October 2017

Berbeda dengan Tuan Guru (pemimpin agama) yang merupakan figure penting dan berpengaruh, bukan hanya agama tetapi juga politik dan budaya, di Lombok, para istri mereka bukanlah tokoh dunia publik. Pengamatan demikian mungkin saja mengindikasikan terjadinya proses domestikasi yang lalu mengakibatkan subordinasi dalam relasi keluarga Tuan Guru. Penelitian ini menawarkan nuansa dan pemahaman lain dalam melihat relasi gender pada keluarga Tuan Guru, dengan menggarisbawahi cairnya demarkasi ruang public dan private yang terjadidi dalamnya. Penelitian ini mengungkap bagaimana sesungguhnya para istri Tuan Guru memposisikan dirinya dalam relasi kuasa pernikahan yang memberikan kesan bahwa relasi gender itu tidak linier dan kaku tetapi kompleks dan cair. Pembagian ruang public dan private adalah isu penting bagi gerakan feminis.Agama, negara, dan keluarga dikritisasi sebagai lembaga-lembaga yang melanggengkan istrinisasi karena mereka masing-masing adalah dasar bagi, alat untuk, dan tempat bagi suburnya budaya patriarkhi. Ideologi gender yang dianut oleh Indonesia sebagaimana yang termaktub dalam UU perkawinan No 1/1974 misalnya membenarkan dikotomi laki-laki sebagai kepala keluarga dan perempuan adalah iburumah tangga. Negara,melalui system hukumnya, secara aktif memapankan pembagian yang kaku ini sembari menyamarkan berbagai fakta yang terjadi tentang bagaimana sesungguhnya perempuan Indonesia menegosiasikan pembagian yang kaku tersebut. Berdasarkan interview mendalam dengan para istri Tuan Guru dari tiga pondok pesantren yang terbesar di Lombok, penelitian ini mengungkap bahwa pembagian ruang public dan privat dalam keluarga Tuan Guru adalah sebuah cara untuk menegaskan identitas domestic seorang istri dan mendukung komitmen publik para Tuan Guru. Dalam beberapa poin, cara pandang ini memang mengadopsi ideologi yang ditanamkan oleh Negara sebagaimana dikemukakan di atas, tetapi dengan beberapa modifikasi. Garis pemisah antara ruang public dan domestic tidak selalu jelas karena para istripun bertanggungjawab dan terlibat aktif dalam kehidupan pesantren termasuk dalam bidang managemen, pendidikan, keuangan serta aktif berpartisipasi dalam pengembangan dan tanggungjawab social lembaga pesantren. Keterlibatan public istri tuan guru tersebut, hanya saja, bukan atas nama gerakan aktivisme atau pembebasan perempuan, tetapi lebih sebagai mendaulatkan diri mereka sebagai pemain belakang layar yang sangat menentukan keberhasilan perjuangan sosial para Tuan Guru. Di sinilah letak kompleksitas relasi gender itu.
REKONFIRMASI LEGITIMASI RUU KEADILAN DAN KESETARAAN GENDER PERSPEKTIF MAQOSHID SYARIAH
Authors: Suhaeri Suhaeri 
Published: October 2017

Ratification of the Justice and Gender Equality (KKG) bill has been delayed since its inception on August 24, 2011. The bill has not been passed in legislation by the Parliament allegedly due to the harsh response of many people, especially Moslems, who consider the KKG bill contrary to the teachings and religious values of Islam, and laden with western ideology and culture. Is the KKG bill legitimate? This article attempts to situate the debate over the proposed KKG bill by reviewing the reasons of the two opposing maqashid Sharia methods.
HOMOSEXUALITY ISLAM AND HUMAN RIGHTS PERSPECTIVES
Authors: Qibtiyah Alimatul 
Published: October 2017

Setiap manusia yang hidup di dunia ini semestinya mempunyai hak yang sama untuk mendapatkan kebutuhan-kebutuhan dasarnya. Namun demikian realitasnya tidak seperti itu. Kelompokkelompok marginal seperti kelompok LGBT akan banyak mendapatkan diskriminasi. Bahkan pendiskriminasian itu sering dilegitimasi sebagai kutukan Tuhan di dunia. Tulisan ini akan mendiskusikan bagaimana Islam dan ummat Islam melihat fenomena homoseksualitas baik dari sisi teologis maupun sosiologisnya. Kelompok yang tidak setuju dengan keberadaan kaum gay ini, berargumen bahwa itu adalah penyimpangan sedangkan kelompok yang peduli melihat bahwa untuk menjadi gay, waria ataupun lesbi bukanlah pilihan dia tetapi itu juga pemberian dari Tuhan,karena itu tidak adil jika mereka diperlakukan tidak adil dari apa yang terjadi pada mereka yang sebenarnya mereka tidak minta. Perbedaan ini tidak lepas dari pendekatan yang digunakan dalam memahami text-text keagamaan.
Analysis of Premature Wear-Out of Aircraft Gun Barrel by Applying a Transmission Electron Microscopy (TEM)
Authors: Łęczycki Krzysztof 
Published: October 2017

Abstract
Firing from gun armament generates a wide range of physico-chemical phenomena contributing to the degradation of barrel material, e.g. pressure, high temperature, chemically aggressive character of post-detonation gases and friction of a driving band. In this work the technique of thin foils was used in Transmission Electron Microscopy (TEM) to study the influence of physicochemical phenomena on the material microstructure of aircraft gun barrel. A mechanism and reason of premature wear-out of the barrel under consideration was also outlined by utilising light microscopy and hardness measurements.
Reluctance Network Model of a Permanent Magnet Tubular Motor
Authors: Waindok Andrzej , Tomczuk Bronisław 
Published: October 2017

Abstract
The reluctance network model of a permanent magnet tubular motor (PMTM) has been presented in the paper. The reluctance values of the magnetic circuit have been calculated with using analytical expressions. The air gap reluctance has been determined with using both analytical expressions and the finite element method (FEM). Using the calculation model, the flux values coupled with the windings have been obtained and used in the calculations of force value. The calculated results have been compared with numerical and measured ones.
Increasing of Energy Efficiency of Spindles with Fluid Bearings
Authors: Fedorynenko Dmytro , Sapon Serhii , Boyko Sergiy , Urlina Anastasiia 
Published: October 2017

Abstract
Promising ways of energy efficiency gain of spindles with fluid flow bearings are offered. New design of journal hybrid flow bearing which contains spherical bearing pockets and adjustable valves with relay control system is offered to improve energy efficiency of spindle units of machine tools. To reduce power losses of fluid bearings at high speed special lubrication based on water with integrated system of corrosion protection is offered. Results of theoretical research of energy consumption of grinding machine tool with a new design of spindle hybrid bearings are presented. Power losses of the spindle unit with both new design and base design of journal bearings are assessed. Effectiveness of new design of spindle hybrid bearings at high operating speeds is shown.
Structural Tests of Freight Wagons on the Basis of Signals Generated By Piezoelectric Macro Fiber Composites
Authors: Płaczek Marek , Wróbel Andrzej , Buchacz Andrzej 
Published: October 2017

AbstractPaper presents a report of a research work that concerns possibilities of freight wagons modernization using new composite materials. The main aim of presented work was to verify the possibility of inference from the dynamic response of the wagon about the changes in its technical condition. During the presented works tests on real objects were carried out using Macro Fiber Composite (MFC) piezoelectric transducers glued to the freight wagon’s frame. The dynamical response of the wagon was measured while the object was driving. On the next stage the measured signal was generated on a laboratory stand using electrodynamic modal shaker and vibrations of the laboratory model were measured. Measured signals were juxtaposed on charts and analysed. The aim of this work was to verify if it is possible to detect the change in the system using measurements of vibrations that are being generated during exploitation of the freight wagon.
Detection Damage in Bearing System of Jet Engine Using the Vibroacoustic Method
Authors: Żokowski Mariusz , Majewski Paweł , Spychała Jarosław 
Published: October 2017

Abstract
The article discusses typical, operational systems for monitoring vibrations of jet engines, which constitute the propulsion of combat aircraft of the Armed Forces of the Republic of Poland. After that, the paper presents the stage of installing vibration measuring sensors in the direct area of one of the jet engine bearings, which is a support system for its rotor. The article discusses results of carried out analyses of data gathered during tests of the engine in the conditions a jet engine test bed. Results of detecting damages to the bear-ing, using sensors built in the direct area will be presented.
Determination of a Vibrating Bowl Feeder Dynamic Model and Mechanical Parameters
Authors: Sturm Martin , Pesik Lubomir 
Published: October 2017

Abstract
Vibrating conveyors also named bowl feeders are a common equipment for conveying goods into production systems. These systems are used for the supplying of a certain number of goods to an individual designed interface and simultaneously arranging a correct orientation of the goods conveyed by the same time. This type of conveyor is used in various industries, such as for example automotive industry, electronic industry and medical industry. The target of this article is to determine a dynamic model and mechanical parameters by means of testing, and a numerical simulation of a ready-to-operate conveyor under standard working conditions.
Economic Assessment of European Beech and Turkey Oak Stands with Close-to-Nature Forest Management
Authors: Csépányi Péter , Csór Attila 
Published: October 2017

AbstractThe paper analyses the complex economic models of continuous cover forestry based on the ‘Dauerwald’ principles in the early transformation period and in the traditional rotation system both in European beech (Fagus sylvaticaL.) and Turkey oak (Quercus cerrisL.) stands in central Hungarian study sites. The analysis was carried out on both the stand and estate-levels, and the performances were compared as well. We found that continuous cover forest management (CCF) can achieve at least the same economic efficiency as traditional rotation forest management (RF) in both beech and in Turkey oak stands. The regeneration problems occurring in poor quality sites in Turkey oak stands made visible the economic differences between the two management systems investigated.
The Effect of Artificial Lights on Nocturnal Macrolepidoptera (Lepidoptera: Macroheterocera) Communities
Authors: Nagy Pintérné Edit , Pödör Zoltán 
Published: October 2017

AbstractWe examined the light sources and illuminated environments in Sopron’s public areas and studied the impact they had on the composition of macrolepidopteran moth communities. We employed light traps with three different light sources in three differently illuminated environments (seminatural, transitional, urban) on 60 occasions during the summer period of 2012-2013 and 20 times in the seminatural area in the spring and autumn of 2014. In the first two years, we evaluated the number of individuals; in year three, we evaluated the number of species. In the first two years, the high-pressure sodium light in the seminatural site trapped the largest number of nocturnal lepidopteran specimens (2,569), while the mixed HMLI light trapped the most individuals in the transitional (1,098) and urban (822) areas. Based on the average number of individuals the first two years, we compared the locations and light sources. In terms of average number of specimens collected, significant differences emerged between two light sources and two locations. When we completed the species diversity index, we determined the compact fluorescent tube in spring and the high-pressure sodium light in the autumn showed the greatest values.
Supporting the Absorbent National Rural Development Planning by Scenarios
Authors: Korompai Attila , Szabó Mátyás , Nováky Erzsébet 
Published: October 2017

Abstract
The practice of Hungarian rural development planning shows the lack of future orientation. The time horizon of planning is short-term, the strategic way of thinking beyond 7–10 years long period is missing or it has great deficiencies. It is not even considering the long-term opportunities. Therefore, the short term plans are not derived from established perspectives, they do not have sufficient grounds. This paper briefly summarises the achievements of a research activity to make an attempt to prove that despite the limitations in understanding and unfolding the future, it is possible to provide useful information for the planning of rural development in 20 – 30 years or even on several more years. This is based on pre-scenarios, highlighting the high efficiency and unexpected weak signals of the driving forces.
Rural Enterprise Hub Supporting Rural Entrepreneurship and Innovation – Case Studies from Hungary
Authors: Katonáné Kovács Judit , Zoltán Erzsébet Szeréna 
Published: October 2017

Abstract
Although the tendency that the population migrate from rural to urban areas is typical world wide, the globalised economy creates new circumstances and opportunities for rural areas as well. The ‘new rural economy’ therefore needs new infrastructure to support it. The authors of the paper have a common interest in how enterprise hubs could help the development of entrepreneurship in the 21st century from two different directions, from physical and from social aspects. Building on the experience gained along enterprise hubs in cities, the hypothesis behind the study is, that creating enterprise hubs from existing buildings in rural settlements could help the development of rural entrepreneurship. To examine the hypothesis two case studies following a period of two years (enterprise hub development in Debrecen and Noszvaj) were carried out. In line with other studies in this field, result shows that even well-designed physical spaces are not enough for change, and initiators, hosts or facilitators are needed, as they play an important role in focusing on the real interaction network and enabling more synergies to happen.
Economic and Social Impacts of Promoting Cultural Heritage Protection by the Czech Rural Development Programme 2007–2013
Authors: Kouřilová Jana , Pělucha Martin 
Published: October 2017

Abstract
Cultural heritage can play a very important role in local and regional development with economic and social effects. The European Union (EU) outlined a specific measure that is aimed at the protection and development of rural heritage within rural development policy in the programming period of 2007–2013. The main aim of this paper is to assess economic and social impacts of projects supported by EU Rural Policy in the Czech Republic during the period of 2007–2013. The implemented projects were located mainly in peripheral rural areas, both near to borders and in inner peripheries, which means that the measure was geographically well targeted. The results of the measure contribute to the restoration and reconstruction of historical monuments, churches, cemeteries and small sacral monuments which create an environment in rural settlements. This environment is very important for the community life and strengthening local identity. In the field of economic development, the results of this measure demonstrate only limited effects in supported villages.
Spatial Planning Experiences for Vulnerability Reduction in the Wildland-Urban Interface in Mediterranean European Countries
Authors: Galiana-Martín Luis 
Published: October 2017

AbstractExpansion of the wildland-urban interface in countries in the European Mediterranean basin is increasing vulnerability to forest fires. Despite more effective extinction systems, this is still a growing problem. This article defends the importance of spatial planning (land-use and urban planning) and the need for systematic intervention to mitigate this wildfire risk. A critical review of the current situation, noting intervention focused on buildings and plots and insufficient action on intermediate spatial scales, is followed by the presentation of significant and relevant experiences in the European context.