bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Two Lead Complexes of Propellant Stabilizer Compounds: In Pursuit of Novel Propellant Additives
Authors: Lundell Carl E. , O'Sullivan Owen T. , Gau Michael R. , Zdilla Michael J. 
Published: December 2017

AbstractTwo lead complexes, Tetrakis(μ3‐(4‐methyl‐3‐nitrophenyl imido lead (II))) 1, and Bis(2‐nitrodiphenyl amido lead(II)) 2, were prepared by protolysis of bis(bis(trimethylsilyl)amido)lead(II) with two compounds relevant to double‐base propellant stabilizers: 2‐nitrodiphenylamine (NDPA) and 4‐methyl‐3‐nitroaniline. Crystal structures were determined as tetrahydrofuran solvates, and exhibit a number of unusual geometric features, including low lead coordination number. Heats of combustion and formation were determined using bomb calorimetry and converted to energy density using crystallographic densities. Compound 1 has an energy density of 30 MJ/L, whereas 2 was 38.2 MJ/L.
302 W triple-frequency, single-mode, linearly polarized Yb-doped all-fiber amplifier
Authors: Zhao Xiang , Yang Yifeng , Shen Hui , Chen Xiaolong , Bai Gang , Zhang Jingpu , Qi Yunfeng , He Bing , Zhou Jun 
Published: December 2017

Stimulated Brillouin scattering (SBS) effect is currently the major limitation for the power scaling of single-frequency/narrow linewidth fiber laser systems. A single-mode linearly polarized all-fiber amplifier system is set up to investigate SBS effect in triple-frequency high-power amplifiers. With this amplifier, up to 302 W output power with 83% slope efficiency is achieved and the SBS threshold is scaled up to 12 dB. To the best of our knowledge, this is the highest output power of multifrequency laser from a single-mode polarization maintaining fiber. Good spectral properties and high brightness make this laser source available for the application of second harmonic generation, coherent beam combining.
Decision-making in plants under competition
Authors: Gruntman Michal , Groß Dorothee , Májeková Maria , Tielbörger Katja 
Published: December 2017

AbstractPlants can plastically respond to light competition in three strategies, comprising vertical growth, which promotes competitive dominance; shade tolerance, which maximises performance under shade; or lateral growth, which offers avoidance of competition. Here, we test the hypothesis that plants can ‘choose’ between these responses, according to their abilities to competitively overcome their neighbours. We study this hypothesis in the clonal plant Potentilla reptans using an experimental setup that simulates both the height and density of neighbours, thus presenting plants with different light-competition scenarios. Potentilla reptans ramets exhibit the highest vertical growth under simulated short-dense neighbours, highest specific leaf area (leaf area/dry mass) under tall-dense neighbours, and tend to increase total stolon length under tall-sparse neighbours. These responses suggest shifts between ‘confrontational’ vertical growth, shade tolerance and lateral-avoidance, respectively, and provide evidence that plants adopt one of several alternative plastic responses in a way that optimally corresponds to prevailing light-competition scenarios.
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
Authors: Hussein Hosni A. M. , Akula Shaw M. 
Published: December 2017

AbstractKaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry. We recently demonstrated that KSHV induces a plethora of host cell miRNAs during the early stages of infection. In this study, we show the ability of host cell novel miR-36 to specifically inhibit KSHV-induced expression of interferon induced transmembrane protein 1 (IFITM1) to limit virus infection of cells. Transfecting cells with miR-36 mimic specifically lowered IFITM1 expression and thereby significantly dampening KSHV infection. In contrast, inhibition of miR-36 using miR-36 inhibitor had the direct opposite effect on KSHV infection of cells, allowing enhanced viral infection of cells. The effect of miR-36 on KSHV infection of cells was at a post-binding stage of virus entry. The highlight of this work was in deciphering a common theme in the ability of miR-36 to regulate infection of closely related DNA viruses: KSHV, Epstein-Barr virus (EBV), and herpes simplexvirus-2 (HSV-2). Taken together, we report for the first time the ability of host cell miRNA to regulate internalization of KSHV, EBV, and HSV-2 in hematopoietic and endothelial cells.
Progress towards rubella elimination after implementation of rubella immunization for over 20 years in Shandong province, China
Authors: Wang Changyin , Zhu Zhen , Xu Qing , Fang Xueqiang , Liu Xiaodong , Xiong Ping , Song Lizhi , Xu Wenbo , Xu Aiqiang 
Published: December 2017

AbstractThe rubella vaccine has been included in the immunization program in Shandong province of China since 1995. Here we observed the rubella vaccine coverage, epidemiology, serosurvey, and virological surveillance data, in order to identify the challenges impeding the progress towards to its elimination following the implementation of rubella immunization over a 21-year period in Shandong province. We first noted that the annual increase in vaccination coverage resulted in decreased rate of rubella incidence, which was maintained at a low level. Second, the average age of rubella patients had shifted to the 15–29-year age group, making this group the main population affected by the rubella virus (RV). Third, more than 90% of the study population were immune to rubella. However, the positive rate of rubella IgG in some cities was relatively lower indicating that an insufficient proportion of individuals had been vaccinated. Finally, the transmission of the genotype 1E RV was gradually interrupted due to the implementation of rubella vaccination. Unfortunately, the endemicity of the imported genotype 2B RV was established due to the pockets with unvaccinated people. Therefore, comprehensive vaccination coverage of the population, combined with high quality monitoring of rubella, is necessary to achieve the rubella elimination goal.
SEPIA – a new single pixel receiver at the APEX telescope
Authors: Belitsky V. , Lapkin I. , Fredrixon M. , Meledin D. , Sundin E. , Billade B. , Ferm S.-E. , Pavolotsky A. , Rashid H. , Strandberg M. , Desmaris V. , Ermakov A. , Krause S. , Olberg M. , Aghdam P. , Shafiee S. , Bergman P. , De Beck E. , Olofsson H. , Conway J. , De Breuck C. , Immer K. , Yagoubov P. , Montenegro-Montes F. M. , Torstensson K. , Pérez-Beaupuits J.-P. , Klein T. , Boland W. , Baryshev A. M. , Hesper R. , Barkhof J. , Adema J. , Bekema M. E. , Koops A. 
Published: December 2017

Context. We describe the new Swedish-ESO PI Instrument for APEX (SEPIA) receiver, which was designed and built by the Group for Advanced Receiver Development (GARD), at Onsala Space Observatory (OSO) in collaboration with ESO. It was installed and commissioned at the APEX telescope during 2015 with an ALMA Band 5 receiver channel and updated with a new frequency channel (ALMA Band 9) in February 2016.
Aim. This manuscript aims to provide, for observers who use the SEPIA receiver, a reference in terms of the hardware description, optics and performance as well as the commissioning results.
Methods. Out of three available receiver cartridge positions in SEPIA, the two current frequency channels, corresponding to ALMA Band 5, the RF band 158–211 GHz, and Band 9, the RF band 600–722 GHz, provide state-of-the-art dual polarization receivers. The Band 5 frequency channel uses 2SB SIS mixers with an average SSB noise temperature around 45 K with IF (intermediate frequency) band 4–8 GHz for each sideband providing total 4 × 4 GHz IF band. The Band 9 frequency channel uses DSB SIS mixers with a noise temperature of 75–125 K with IF band 4–12 GHz for each polarization.
Results. Both current SEPIA receiver channels are available to all APEX observers.
Visceral Adiposity Is an Independent Determinant of Hypercoagulability as Measured by Thrombin Generation in Morbid Obesity
Authors: Chitongo P. , Roberts L. , Yang L. , Patel R. , Lyall R. , Luxton R. , Aylwin S. , Arya R. 
Published: December 2017

Introduction Increased visceral adipose tissue (VAT) has been shown to be associated with the development of insulin resistance, type 2 diabetes, stroke, and ischemic heart disease. It remains unknown whether fat distribution impacts on coagulation markers and/or the risk of venous thrombosis. This study evaluates markers of hypercoagulability in class III obesity (body mass index [BMI] >40 kg/m2) compared with nonobese controls. We further investigated whether hypercoagulability was influenced by VAT, metabolic syndrome, and metabolic markers, including adiponectin.
Patients and Methods Ninety patients were recruited from the obesity clinic at King's College Hospital from November 2009 to December 2011. The inclusion criteria were class III obesity (BMI ≥40 kg/m2) and age 18 to 65 years. A control group (healthy ambulatory participants, with a BMI < 30 kg/m2) was recruited from volunteers responding to advertisement. Abdominal VAT and subcutaneous adipose tissue surface areas were determined by evaluation of a single-slice CT at spinal vertebra L4.
Results Thrombin generation revealed a significantly increased peak and endogenous thrombin potential in patients compared with controls. Lag time and time to peak (ttP) were also significantly prolonged in patients. VAT was found to have the strongest association with thrombin generation parameters: lag time (β = 0.378; p < 0.001), peak thrombin (0.378; p = 0.04), and ttP (β = 0.373; p = 0.001). BMI was found to be a predictor for lag time only (β = 0.313; p = 0.003). SAT was not associated with any of the thrombin generation parameters (data not shown). VAT was found to be an independent determinant of peak thrombin, lag time, and ttP. The study suggests not only fat mass but also fat distribution, particularly visceral adiposity, mediates hypercoagulability in obesity.
Using networks in plant disease diagnosis.
Authors: Vakilian K. A. 
Published: December 2017

Abstract
Nowadays, hundreds of plant clinics are available for smallholder farmers especially in developing and less-developed countries in order to improve the yield and quality of agricultural products. Several investigations have been carried out to study the role of plant clinics as diagnostics and advisory centres in agricultural extension. However, it seems that there is no comprehensive study demonstrating the role of plant disease diagnosis networks and plant clinics in the development of the farmers' agricultural knowledge. This knowledge can cover a general understanding of integrated nutrient and pest management programmes, principles of agronomy, and simple disease diagnosis methods. In this review paper, the concept of the plant clinic is introduced and then the services which a plant clinic can provide to the farmers are investigated. Criteria for assessing the performance of plant clinics are reviewed to obtain an appropriate and reliable methodology to evaluate the efficiency of these clinics. The characteristics of successful plant diagnosis networks in collaboration with farmers and other entities are presented. Finally, several national and international plant diagnosis networks are introduced and their impact on global agricultural extension is discussed.
Criticizing Kings: Gender, Classical History, and Subversive Writing in Seventeenth-Century England
Authors: Gianoutsos Jamie 
Published: December 2017

AbstractThis article provides one of the first studies of two late works by George Chapman, “Pro Vere” (1622) and “A iustification of a strange action of Nero” (1629). Through a close examination of these works, and through situating Chapman’s texts alongside other neglected works of the 1620s that voiced opposition to the Stuart court and kings, the article examines the critical and subversive role that classical history and gendered language played in forging ideological conflict in England during the Stuart period. More broadly, the article seeks to demonstrate the importance of studying imaginative writings for understanding Stuart political culture.
Estimating post-release mortality of European sea bass based on experimental angling
Authors: Lewin Wolf-Christian , Strehlow Harry Vincent , Ferter Keno , Hyder Kieran , Niemax Jan , Herrmann Jens-Peter , Weltersbach Marc Simon 
Published: December 2017

AbstractEuropean sea bass (Dicentrarchus labrax) is an important target species for recreational and commercial fisheries. In recent years, the spawning stock biomass has declined markedly in some areas, and strict management measures have been introduced. However, the development of appropriate stock assessment and fisheries management has been hampered by a lack of information on post-release mortality. This study investigated post-release mortality of sea bass captured with common recreational fishing gear under experimental conditions in an aquaculture facility over 10 d. Three experiments investigated: (i) the effects of different bait types; (ii) the impact of prolonged air exposure; and (iii) the impact of deep hooking on post-release mortality. By combining the experimental results with country-specific information on sea bass angling practices, estimates of post-release mortality are provided for the northern sea bass stock. No mortality was observed for sea bass captured on artificial baits. The use of natural baits resulted in a mortality of 13.9% (95% CI = 4.7–29.5%), which was associated with deep hooking, hooking injuries, and prolonged air exposure. The use of artificial baits and short air exposure (≤30 s) increased survival probability, whereas deep hooking resulted in 76.5% (95% CI = 50.0–93.2%) mortality. Depending on country-specific angling practices, post-release mortality estimates ranged from 2.8% to 9.1% (mean = 5.0%, 95% CI = 1.7–14.4%) for northern sea bass. Despite these relatively low mortality estimates, post-release mortality should be considered in stock assessments as its cumulative impact may be high. Moreover, post-release mortality can be reduced by implementing species-specific best practice guidelines.
4-Meter Gait Speed Test in Chronic Obstructive Pulmonary Disease
Authors: Bisca Gianna Waldrich , Fava Lucas Rodrigues , Morita Andrea Akemi , Machado Felipe Vilaça Cavallari , Pitta Fabio , Hernandes Nidia Aparecida 
Published: December 2017

Purpose:
4-meter gait speed (4MGS) is increasingly used to assess functional performance in patients with chronic obstructive pulmonary disease. However, the current literature lacks information regarding some technical standards for this test. Therefore, the purpose of this study was to compare and to evaluate the interrater reliability between a stopwatch and video recording used as timing systems for the 4MGS in patients with chronic obstructive pulmonary disease, as well as to verify the interrater reliability between 2 observers measuring the 4MGS time using a manual stopwatch.

Methods:
Fifty-one patients performed the 4MGS using 4 different protocols (random order): walking at the usual and maximum speed in a 4-meter course and walking at the same 2 speeds on an 8-m course using a 2-m acceleration zone, a 4-meter timing area, and a 2-m deceleration zone. Gait speed was measured simultaneously using a stopwatch and a video recording. In a subanalysis (n = 24), 2 independent observers timed the 4MGS using a stopwatch.

Results:
There was no significant difference in comparison between the 2 timing methods (P > .05 for all), and the reliability between video recording and stopwatch was excellent in all 4MGS studied protocols (intraclass correlation coefficient ≥ 0.91). Moreover, when comparing gait speed measured by 2 observers using a stopwatch, no significant difference was found among all proposed protocols (P > .05 for all), and there was also excellent reliability between the 2 independent observers (intraclass correlation coefficient ≥ 0.94).

Conclusion:
The stopwatch, a low-cost and feasible tool, is reliable as a timing device for the 4MGS in patients with chronic obstructive pulmonary disease.
TREATMENT OF EXUDATIVE CIRCUMSCRIBED CHOROIDAL HEMANGIOMA
Authors: Mahdjoubi Amir , Dendale Rémi , Desjardins Laurence , Lemaitre Stéphanie , Lumbroso-Le Rouic Livia , Goudjil Farid , Cassoux Nathalie , Levy-Gabriel Christine 
Published: December 2017

Purpose:
To evaluate treatment of circumscribed choroidal hemangioma by hyperfractionated proton beam therapy protocol (20 gray relative biological effectiveness in 8 fractions) on tumor control, attachment of retina and visual function.

Methods:
Retrospective review of patients treated between January 2010 and April 2015 with at least 6 months of follow-up.

Results:
Forty-three patients with exudative and symptomatic circumscribed choroidal hemangioma were included. Before treatment, 41 (95%) presented an exudative retinal detachment, median visual acuity was 20/63 and median tumor thickness was 3.3 mm. Mean follow-up was 26 months (7–62). At last follow-up, all patients presented regression of ultrasound tumor thickness and 23/43 (53.5%) a totally flat scar. The mean time to achieve a flat scar was 20 months. Retina was reattached in all patients except one with 9 months of follow-up. Visual acuity was improved or stabilized in 37 patients (86%) and final median visual acuity was 20/25. No patient presented radiation maculopathy or papillopathy.

Conclusion:
Proton beam therapy with a dose of 20 gray relative biological effectiveness delivered in 8 fractions provides excellent anatomical and functional results and are comparable with those obtained with the same dose delivered in 4 fractions. Longer follow-up is required to determine the long-term radiation sequelae.
Follow the Yellow Brick Road
Authors: Morrison Caroline F. , Martsolf Donna , Borich Annamarie , Coleman Kristen , Ramirez Patricia , Wehrkamp Nicole , Tehan Rebecca , Woebkenberg Katherine , Pai Ahna L.H. 
Published: December 2017

Background
Stem cell transplant (SCT) is a major life event that can have long-term psychosocial consequences for the entire family. It is unknown the degree to which the psychosocial characteristics associated with SCT influence self-management behaviors and health outcomes in adolescents and young adults (AYAs).

Objective
The study had the following aims: (1) to describe how AYAs manage their care regimen post-SCT and (2) to explore self-management facilitators, barriers, processes, and behaviors within individual, family, community, and healthcare system domains.

Interventions/Methods
A grounded theory study was conducted to understand the process AYAs use to manage their care after SCT. Semistructured individual interviews were conducted, digitally recorded, and transcribed verbatim. Data were coded to consensus and analyzed using constant comparison methods.

Results
A sample of 17 AYAs (13-25 years old at transplant) and 13 caregivers (dyads) participated in the study. Initially, the participants experienced a tornado of activities, information, and emotions. Support from family, friends, and healthcare providers empowered families to manage their care, maintain a positive attitude, and approach a “normal” life.

Conclusions
Monotony, managing symptoms, and isolation were the hardest obstacles for AYAs throughout the process. Families discussed managing their care activities by developing routines that got easier with time.

Implications for Practice
Nurses play an instrumental role in AYA self-management practices by providing information, education, and social support. Psychosocial issues were prominent in the self-management process and should be addressed in future research and interventions with AYAs and caregivers.
AntAngioCOOL: An R Package for Computational Detection of Anti-Angiogenic Peptides
Authors: Zahiri Javad , Khorsand-Ghaffari Babak , Shirali Hossein Zade Ramin , Kargar Mohammadjavad , Yousefi Ali Akbar 
Published: December 2017

ABSTRACTAngiogenesis inhibition research is a cutting edge in angiogenesis-dependent disease therapy, and especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in the cancer treatment field. In the current study we propose an effective machine learning based R package (AntAngioCOOL) to predict anti-angiogenic peptides. We have examined more than 200 different classifiers to build an efficient predictor. Also, more than 17000 features have been extracted to encode the peptides. However, finally, more than 2000 informative features have been selected to train the classifiers. According to the obtained results AntAngioCOOL can effectively predict anti-angiogenic peptides: this tool achieved sensitivity of 88%, specificity of 77% and accuracy of 75% on independent test set. AntAngioCOOL can be accessed at https://cran.r-project.org/.
Workload smoothing in two-sided assembly lines
Authors: Hu Xiaofeng , Wu Chunaxun 
Published: December 2017

Purpose
The purpose of this paper is to define new criteria for measuring workload smoothness of two-sided assembly lines and propose an algorithm to solve a two-sided assembly line balancing problem focusing on distributing the idle time and the workload as evenly as possible among the workstations.

Design/methodology/approach
This paper points out that the mean absolute deviation (MAD) and the smoothness index (SI) used to measure the workload smoothing in one-sided assembly lines are both inappropriate to evaluate the workload balance among workstations in two-sided assembly lines, as the idle time occur at the beginning and in the middle of a cycle within workstations. Then, the finish-time-based SI and MAD (FSI and FMAD) are defined, and a heuristic procedure based on the core mechanism of Moodie and Young method is proposed to smooth the assembly workload in two-sided assembly lines.

Findings
The computational results indicate that the proposed heuristic algorithm combined with the FMAD is effective in distributing the idle time and the workload among workstations as evenly as possible in two-sided assembly lines.

Practical implications
The two-sided assembly line balancing problem with the objective of the line efficiency can be effectively solved by the proposed approach.

Originality/value
The FMAD is proposed to effectively improve the workload smoothing in two-sided assembly lines.