bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic in vivo evaluation of the time-dependent inflammatory response to steel and Teflon insulin infusion catheters
Authors: Hauzenberger Jasmin R. , Münzker Julia , Kotzbeck Petra , Asslaber Martin , Bubalo Vladimir , Joseph Jeffrey I , Pieber Thomas R. 
Published: January 2018

AbstractContinuous subcutaneous insulin infusion (CSII) catheters are considered the weak link of insulin pump therapy. Wear-time considerably varies between patients and the choice of catheter material is based on personal preferences rather than scientific facts. Therefore, we systematically assessed and quantified the inflammatory tissue response to steel versus Teflon CSII catheters over a maximum wear-time of 7 days in swine. Tissue surrounding catheters was analysed using histopathology and quantitative real-time PCR. The area of inflammation increased significantly over time independent of material which was confirmed by an increase in CD68 expression and an increase in mononuclear and neutrophil cell infiltrate around the catheters. We observed substantially higher fibrin deposition (p < 0.05) around steel on day 4 of wear-time. IL-6 gene expression increased within 24 hours after insertion, returned to normal levels around Teflon (p < 0.05) but remained high around steel (p < 0.05). IL-10 and TGF-β levels did not resolve over time, indicating impaired wound healing. In conclusion, there was a major temporal effect in the acute inflammatory response to CSII catheters but we found little difference between materials. This study setup presents a robust tool for the systematic analysis of the tissue response to CSII catheters.
High-throughput analysis using non-depletive SPME: challenges and applications to the determination of free and total concentrations in small sample volumes
Authors: Boyacı Ezel , Bojko Barbara , Reyes-Garcés Nathaly , Poole Justen J. , Gómez-Ríos Germán Augusto , Teixeira Alexandre , Nicol Beate , Pawliszyn Janusz 
Published: January 2018

AbstractIn vitro high-throughput non-depletive quantitation of chemicals in biofluids is of growing interest in many areas. Some of the challenges facing researchers include the limited volume of biofluids, rapid and high-throughput sampling requirements, and the lack of reliable methods. Coupled to the above, growing interest in the monitoring of kinetics and dynamics of miniaturized biosystems has spurred the demand for development of novel and revolutionary methodologies for analysis of biofluids. The applicability of solid-phase microextraction (SPME) is investigated as a potential technology to fulfill the aforementioned requirements. As analytes with sufficient diversity in their physicochemical features, nicotine, N,N-Diethyl-meta-toluamide, and diclofenac were selected as test compounds for the study. The objective was to develop methodologies that would allow repeated non-depletive sampling from 96-well plates, using 100 µL of sample. Initially, thin film-SPME was investigated. Results revealed substantial depletion and consequent disruption in the system. Therefore, new ultra-thin coated fibers were developed. The applicability of this device to the described sampling scenario was tested by determining the protein binding of the analytes. Results showed good agreement with rapid equilibrium dialysis. The presented method allows high-throughput analysis using small volumes, enabling fast reliable free and total concentration determinations without disruption of system equilibrium.
The Proliferation Capacity of Cultured Neural Stem Cells Promoted by CSF Collected from SAH Patients Correlates to Clinical Outcome
Authors: Chen Yun-An , Wang Kuo-Chuan , Liu Der-Zen , Young Tai-Horng , Tsai Li-Kai 
Published: January 2018

AbstractNeurogenesis from endogenous neural stem cells (NSCs) might contribute to functional recovery after stroke based on animal studies; however, the relationship between neurogenesis and post-stroke outcome has rarely been demonstrated in humans. We prospectively collected cerebrospinal fluid (CSF) from 36 patients with subarachnoid hemorrhage (SAH). The CSF was added to the culture medium of the rat NSCs to test the effects on proliferation (proliferation index [PI], percentage of Ki-67 immunoreactive cells). We correlated the PI with functional outcome based on the modified Rankin Scale at 3 months post-SAH. Treatment with the CSF samples collected from SAH patients showed a higher PI compared with those collected from patients with normal pressure hydrocephalus and untreated controls (20.3 ± 8.8 vs. 8.2 ± 5.1 and 7.8 ± 3.0, P < 0.001), indicating proliferation-promoting factors in CSF after SAH. The PI was positively correlated with SAH volume (p = 0.025). For patients with lower SAH volume, patients with favorable outcome had a higher PI than those with poor outcome (20.8 ± 6.9 vs. 14.6 ± 4.3, p = 0.047). Using multivariable logistic regression analysis, the PI was a positive determinant for favorable outcome (odds ratio, 1.17; 95% confidence interval, 1.00 to 1.36) that more proliferation-promoting factors in CSF was associated with better functional outcome in SAH patients.
Night eating model shows time-specific depression-like behavior in the forced swimming test
Authors: Haraguchi Atsushi , Fukuzawa Miyabi , Iwami Shiho , Nishimura Yutaro , Motohashi Hiroaki , Tahara Yu , Shibata Shigenobu 
Published: January 2018

AbstractThe circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat dietad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2::LUCIFERASE knock-in mice and anin vivomonitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice’s FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.
Gender-related differences in heart failure with preserved ejection fraction
Authors: Duca Franz , Zotter-Tufaro Caroline , Kammerlander Andreas A. , Aschauer Stefan , Binder Christina , Mascherbauer Julia , Bonderman Diana 
Published: January 2018

AbstractHeart failure with preserved ejection fraction (HFpEF) affects more women than men, suggesting gender to play a major role in disease evolution. However, studies investigating gender differences in HFpEF are limited. In the present study we aimed to describe gender differences in a well-characterized HFpEF cohort. Consecutive HFpEF patients underwent invasive hemodynamic assessment, cardiac magnetic resonance imaging and exercise testing. Study endpoints were: cardiac death, a combined endpoint of HF hospitalization or cardiac death and all-cause death. 260 HFpEF patients were prospectively enrolled. Men were more compromised with regard to exercise capacity and had significantly more co-morbidities. Men had more pronounced pulmonary vascular disease with higher diastolic pressure gradients and a lower right ventricular EF. During follow-up, 9.2% experienced cardiac death, 33.5% the combined endpoint and 17.3% all-cause death. Male gender was independently associated with cardiac death, but neither with the combined endpoint nor with all-cause mortality. We detected clear gender differences in HFpEF patients. Cardiac death was more common among men, but not all-cause death. While men are more prone to develop a right heart phenotype and die from HFpEF, women are more likely to die with HFpEF.
Performance analysis of an adaptive optics system for free-space optics communication through atmospheric turbulence
Authors: Wang Yukun , Xu Huanyu , Li Dayu , Wang Rui , Jin Chengbin , Yin Xianghui , Gao Shijie , Mu Quanquan , Xuan Li , Cao Zhaoliang 
Published: January 2018

AbstractThe performance of free-space optics communication (FSOC) is greatly degraded by atmospheric turbulence. Adaptive optics (AO) is an effective method for attenuating the influence. In this paper, the influence of the spatial and temporal characteristics of turbulence on the performance of AO in a FSOC system is investigated. Based on the Greenwood frequency (GF) and the ratio of receiver aperture diameter to atmospheric coherent length (D/r
0
), the relationship between FSOC performance (CE) and AO parameters (corrected Zernike modes number and bandwidth) is derived for the first time. Then, simulations and experiments are conducted to analyze the influence of AO parameters on FSOC performance under different GF and D/r
0
. The simulation and experimental results show that, for common turbulence conditions, the number of corrected Zernike modes can be fixed at 35 and the bandwidth of the AO system should be larger than the GF. Measurements of the bit error rate (BER) for moderate turbulence conditions (D/r
0
= 10, f
G
= 60 Hz) show that when the bandwidth is two times that of GF, the average BER is decreased by two orders of magnitude compared with f
G
/f
3dB
= 1. These results and conclusions can provide important guidance in the design of an AO system for FSOC.
Broadband wave plates made by plasmonic metamaterials
Authors: Chen Lin , Ke Xianmin , Guo Huijie , Li Junhao , Li Xun , Zhou Lei 
Published: January 2018

AbstractAlthough metamaterials wave-plates have been demonstrated previously, many of them suffer from the issue of narrow bandwidth since they typically rely on resonance principles and thus exhibit inevitable frequency dispersions. Here, we show that the dispersion of spoof surface plasmon (SSP) mode supported by a fishbone structure can be freely modulated by varying the structural parameters. This motivates us to establish a general strategy of building broadband wave-plates by cascading two fishbone structures with different propagation constants of SSP modes. We derive a criterion under which the cross-polarization phase-difference across the whole device can maintain at a nearly constant value over a wide frequency band, with frequency dispersions in the two fishbone structures cancelled out. As an illustration, we design and fabricate an efficient microwave quarter-wave plate and experimentally characterize its excellent polarization-control performances over a broad frequency band (7–9.2 GHz). Our findings can stimulate making dispersion-controlled high-performance optical functional devices in different frequency domains.
Empirical photometric calibration of the Gaia red clump: Colours, effective temperature, and absolute magnitude
Authors: Ruiz-Dern L. , Babusiaux C. , Arenou F. , Turon C. , Lallement R. 
Published: January 2018

Context. Gaia Data Release 1 allows the recalibration of standard candles such as the red clump stars. To use those stars, they first need to be accurately characterised. In particular, colours are needed to derive interstellar extinction. As no filter is available for the first Gaia data release and to avoid the atmosphere model mismatch, an empirical calibration is unavoidable.
Aims. The purpose of this work is to provide the first complete and robust photometric empirical calibration of the Gaia red clump stars of the solar neighbourhood through colour–colour, effective temperature–colour, and absolute magnitude–colour relations from the Gaia, Johnson, 2MASS, Hipparcos, Tycho-2, APASS-SLOAN, and WISE photometric systems, and the APOGEE DR13 spectroscopic temperatures.
Methods. We used a 3D extinction map to select low reddening red giants. To calibrate the colour–colour and the effective temperature–colour relations, we developed a MCMC method that accounts for all variable uncertainties and selects the best model for each photometric relation. We estimated the red clump absolute magnitude through the mode of a kernel-based distribution function.
Results. We provide 20 colour versus G−Ks relations and the first Teff versus G−Ks calibration. We obtained the red clump absolute magnitudes for 15 photometric bands with, in particular, MKs = (−1.606 ± 0.009) and MG = (0.495 ± 0.009) + (1.121 ± 0.128)(G−Ks−2.1). We present a dereddened Gaia-TGAS HR diagram and use the calibrations to compare its red clump and its red giant branch bump with Padova isochrones.
Expansion patterns and parallaxes for planetary nebulae
Authors: Schönberner D. , Balick B. , Jacob R. 
Published: January 2018

Aims.We aim to determine individual distances to a small number of rather round, quite regularly shaped planetary nebulae by combining their angular expansion in the plane of the sky with a spectroscopically measured expansion along the line of sight.Methods.We combined up to three epochs ofHubbleSpace Telescope imaging data and determined the angular proper motions of rim and shell edges and of other features. These results are combined with measured expansion speeds to determine individual distances by assuming that line of sight and sky-plane expansions are equal. We employed 1D radiation-hydrodynamics simulations of nebular evolution to correct for the difference between the spectroscopically measured expansion velocities of rim and shell and of their respective shock fronts.Results.Rim and shell are two independently expanding entities, driven by different physical mechanisms, although their model-based expansion timescales are quite similar. We derive good individual distances for 15 objects, and the main results are as follows: (i) distances derived from rim and shell agree well; (ii) comparison with the statistical distances in the literature gives reasonable agreement; (iii) our distances disagree with those derived by spectroscopic methods; (iv) central-star “plateau” luminosities range from about 2000L⊙to well below 10 000L⊙, with a mean value at about 5000L⊙, in excellent agreement with other samples of known distance (Galactic bulge, Magellanic Clouds, and K648 in the globular cluster M 15); (v) the central-star mass range is rather restricted: from about 0.53 to about 0.56M⊙, with a mean value of 0.55M⊙.Conclusions.The expansion measurements of nebular rim and shell edges confirm the predictions of radiation-hydrodynamics simulations and offer a reliable method for the evaluation of distances to suited objects.
Exposed bright features on the comet 67P/Churyumov–Gerasimenko: distribution and evolution
Authors: Deshapriya J. D. P. , Barucci M. A. , Fornasier S. , Hasselmann P. H. , Feller C. , Sierks H. , Lucchetti A. , Pajola M. , Oklay N. , Mottola S. , Masoumzadeh N. , Tubiana C. , Güttler C. , Barbieri C. , Lamy P. L. , Rodrigo R. , Koschny D. , Rickman H. , Bertaux J.-L. , Bertini I. , Bodewits D. , Boudreault S. , Cremonese G. , Da Deppo V. , Davidsson B. J. R. , Debei S. , De Cecco M. , Deller J. , Fulle M. , Groussin O. , Gutierrez P. J. , Hoang H. V. , Hviid S. F. , Ip W. , Jorda L. , Keller H. U. , Knollenberg J. , Kramm R. , Kührt E. , Küppers M. , Lara L. , Lazzarin M. , Lopez Moreno J. J. , Marzari F. , Naletto G. , Preusker F. , Shi X. , Thomas N. , Vincent J.-B. 
Published: January 2018

Context. Since its arrival at the comet 67P/Churyumov–Gerasimenko in August 2014, the Rosetta spacecraft followed the comet as it went past the perihelion and beyond until September 2016. During this time there were many scientific instruments operating on board Rosetta to study the comet and its evolution in unprecedented detail. In this context, our study focusses on the distribution and evolution of exposed bright features that have been observed by OSIRIS, which is the scientific imaging instrument aboard Rosetta.
Aims. We envisage investigating various morphologies of exposed bright features and the mechanisms that triggered their appearance.
Methods. We co-registered multi-filter observations of OSIRIS images that are available in reflectance. The Lommel–Seeliger disk function was used to correct for the illumination conditions and the resulting colour cubes were used to perform spectrophotometric analyses on regions of interest.
Results. We present a catalogue of 57 exposed bright features observed on the nucleus of the comet, all of which are attributed to the presence of H2O ice on the comet. Furthermore, we categorise these patches under four different morphologies and present geometric albedos for each category.
Conclusions. Although the nucleus of 67P/Churyumov–Gerasimenko appears to be dark in general, there are localised H2O ice sources on the comet. Cometary activity escalates towards the perihelion passage and reveals such volatile ices. We propose that isolated H2O ice patches found in smooth terrains in regions, such as Imhotep, Bes, and Hapi, result from frost as an aftermath of the cessation of the diurnal water cycle on the comet as it recedes from perihelion. Upon the comet’s return to perihelion, such patches are revealed when sublimation-driven erosion removes the thin dust layers that got deposited earlier. More powerful activity sources such as cometary outbursts are capable of revealing much fresher, less contaminated H2O ice that is preserved with consolidated cometary material, as observed on exposed patches resting on boulders. This is corroborated by our albedo calculations that attribute higher albedos for bright features with formations related to outbursts.
Oligodendrogliomas: a genética molecular e o desenvolvimento de estratégia terapêutica adjuvante
Authors: da Fonseca Clovis Orlando , da Gama Fischer Juliana de Saldanha , Masini Marcos , Futuro Débora , Caetano Regina , Gattass Cerli R. , Santos Thereza Q. 
Published: January 2018

ResumoA incidência dos oligodendrogliomas tem aumentado provavelmente em razão do progresso na precisão de diagnóstico. Aproximadamente dois terços dos pacientes com a forma mais agressiva, oligodendroglioma anaplásico, mostram resposta substancial à quimioterapia com a associação procarbazina/lomustina/ vincristina (PCV). Entretanto, os resultados da quimioterapia com PCV para oligodendrogliomas anaplásicos recidivados têm sido limitados. A progressão anaplásica dos oligodendrogliomas resulta em grande número de células com ERK/MAPK ativadas. O monoterpeno álcool perílico demonstra atividades quimiopreventiva e quimioterápica em diversos modelos de tumores e sugere-se que estas possam estar associadas com a capacidade de inibir a farnesilação pós-traducional e a sinalização da Ras, assim como a cascata de sinalização por meio da RAF-MEK-ERK. Estudo do nosso grupo observou que pode estar atuando mediante a inibição da fosforilação da extracellular regulated kinase (ERK), uma proteína envolvida na cascata de transdução de sinal através da membrana e proliferação celular induzida pela proteína Ras. Este artigo discute a redução de oligodendroglioma anaplásico recidivado em paciente tratado durante nove meses com álcool perílico por via intranasal.
Abscessos do tronco cerebral: Apresentação de seis casos
Authors: Kirchhoff Daniel de Carvalho , Kirchhoff Dierk F. B. , Muoio Valeria 
Published: January 2018

ResumoEstudo retrospectivo de seis casos de abscesso de tronco cerebral, atendidos num período de cinco anos em nosso Serviço. Foram levados em consideração: idade dos pacientes, sexo, comorbidades, sorologia para HIV, quadro clínico, tratamento realizado (craniotomia ou punção por estereotaxia), microorganismo identificado e resultado do tratamento.Apresentamos, a seguir, a discussão dos casos e revisão da literatura.
Injeções epidurais de esteroides no tratamento da dor lombar
Authors: Joaquim Andrei F. 
Published: January 2018

Resumo
Contexto: Injeções de corticosteroides no espaço epidural (IEE) fazem parte do arsenal terapêutico no tratamento da dor lombossacral associada à radiculopatia, e sua utilização é crescente em todo o mundo. Objetivo: Revisão dos principais aspectos referentes ao tema, como indicações e contraindicações, eficácia, forma de uso (interlaminar, transforaminal ou sacral), drogas a serem utilizadas e complicações. Método: Pesquisa bibliográfica baseada em dados MedLine (National Library of Medicine), abrangendo o período de 1980 a 2008. As palavras-chave utilizadas foram epidural, steroid injection, lumbar or lumbosacral. Os artigos foram avaliados pelos resumos, selecionando-se também revisões bibliográficas e trabalhos pertinentes ao texto. Realizou-se, além disso, pesquisa manual de eventuais referências cruzadas relevantes de artigos selecionados não encontradas na base de dados e em livros-texto sobre o assunto. Conclusão: A injeção de esteroide no espaço epidural é uma alternativa terapêutica importante no tratamento da dor lombossacral associada à radiculopatia. Novos estudos bem desenhados com diagnósticos clínico e radiológico mais precisos, posologias e técnicas padronizadas podem auxiliar na seleção de subgrupos de pacientes que mais se beneficiarão com o procedimento.
Escrevendo resumos mais informativos
Authors: Paixão Oliveira Débora Moura da , Pereira Carlos Umberto 
Published: January 2018

Resumo
Objetivo: Mostrar os principais achados da pesquisa sobre resumos estruturados e discutir suas limitações, bem como fornecer aos autores inexperientes ou iniciantes as recomendações mínimas necessárias para a construção de um resumo estruturado. Método: Revisão sistemática da literatura médica sobre artigos relevantes. Resultados: Os resumos estruturados são tipicamente mais longos do que os tradicionais, mas são considerados mais informativos e acessíveis. Autores e leitores julgam ser mais úteis do que resumos tradicionais. Entretanto, existem críticas em relação ao uso de resumos estruturados e nem todos os periódicos os adotam. Conclusão: Os resumos estruturados exigem apresentação de achados de maneira sistemática, todavia são melhores que os tradicionais por serem adaptados para a maioria das investigações. A observação dos padrões dos resumos estruturados pode facilitar o processo de escrever, bem como a discussão das características dos resumos estruturados pode ser útil aos futuros autores.
Cavernomas da medula torácica: Considerações e relato de um caso-exemplo
Authors: Stávale Joaquim Marcos Augusto , Patriota Gustavo Cartaxo , Bianco André de Macedo 
Published: January 2018

ResumoOs autores discutem o tratamento dos cavernomas da medula torácica e apresentam um caso como exemplo. Essas lesões são passíveis de ressecção cirúrgica preventiva de déficits neurológicos.
Hemodinâmica do vasoespasmo
Authors: Stávale Joaquim Marcos Augusto , Patriota Gustavo Cartaxo , Bianco André de Macedo 
Published: January 2018

ResumoOs autores descrevem as alterações hemodinâmicas encefálicas que ocorrem na vigência do vasoespasmo após a hemorragia subaracnoidea por aneurismas. O conhecimento dessas alterações facilita o entendimento das medidas terapêuticas.