bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of hepatic trans-arterial chemoembolization in metastatic medullary thyroid carcinoma: a specialist center experience and review of the literature
Authors: Grozinsky-Glasberg S , Bloom A I , Lev-Cohain N , Klimov A , Besiso H , Gross D J 
Published: January 2017

BackgroundLiver metastases are relatively common in patients with metastatic medullary thyroid carcinoma (MTC), carrying a negative impact on disease prognosis. The options for selective therapy of liver metastases in MTC patients are limited to catheter-guided procedures such as trans-arterial chemoembolization (TACE). Data regarding the effectiveness and safety of this procedure in MTC are limited.AimTo explore the clinical outcome, survival and safety profile of TACE for liver metastases in a group of MTC patients.MethodsRetrospective case series of patients treated at a single tertiary University Medical Center from 2005 to 2015.ResultsSeven consecutive patients (mean age 64.5 ± 10.9 years, 5 females) with histologically confirmed MTC with liver metastases were included. Metastatic involvement of the liver was less than 50% of the liver volume in all patients. The median size of the largest liver lesion was 40 ± 6.9 mm. The patients underwent in total 20 sessions of TACE. Clinical improvement as well as tumor response (PR) were observed in all patients. The median time to tumor progression was 38 months (range 8–126). Three patients were still alive at the end of the follow-up period (a median overall survival rate of 57 ± 44 months).ConclusionTACE in MTC patients with hepatic metastases is usually well tolerated and induces both clinical improvement and tumor response for prolonged periods of time in the majority of patients. This therapeutic option should always be considered, irrespective of the presence of extrahepatic metastasis.
External validation of the GREAT score to predict relapse risk in Graves’ disease: results from a multicenter, retrospective study with 741 patients
Authors: Struja Tristan , Kaeslin Marina , Boesiger Fabienne , Jutzi Rebecca , Imahorn Noemi , Kutz Alexander , Bernasconi Luca , Mundwiler Esther , Mueller Beat , Christ-Crain Mirjam , Meienberg Fabian , Ebrahimi Fahim , Henzen Christoph , Fischli Stefan , Kraenzlin Marius , Meier Christian , Schuetz Philipp 
Published: January 2017

Context
First-line treatment in Graves’ disease is often done with antithyroid agents (ATD), but relapse rates remain high making definite treatment necessary. Predictors for relapse risk help guiding initial treatment decisions.

Objective
We aimed to externally validate the prognostic accuracy of the recently proposed Graves’ Recurrent Events After Therapy (GREAT) score to predict relapse risk in Graves’ disease.

Design, setting and participants
We retrospectively analyzed data (2004–2014) of patients with a first episode of Graves’ hyperthyroidism from four Swiss endocrine outpatient clinics.

Main outcome measures
Relapse of hyperthyroidism analyzed by multivariate Cox regression.

Results
Of the 741 included patients, 371 experienced a relapse (50.1%) after a mean follow-up of 25.6 months after ATD start. In univariate regression analysis, higher serum free T4, higher thyrotropin-binding inhibitor immunoglobulin (TBII), younger age and larger goiter were associated with higher relapse risk. We found a strong increase in relapse risk with more points in the GREAT score from 33.8% in patients with GREAT class I (0–1 points), 59.4% in class II (2–3 points) with a hazard ratio of 1.79 (95% CI: 1.42–2.27, P < 0.001) and 73.6% in class III (4–6 points) with a hazard ratio of 2.24 (95% CI: 1.64–3.06, P < 0.001).

Conclusions
Based on this retrospective analysis within a large patient population from a multicenter study, the GREAT score shows good external validity and can be used for assessing the risk for relapse in Graves’ disease, which influence the initial treatment decisions.
Involvement of Conserved Amino Acids in the C-Terminal Region of LINE-1 ORF2p in Retrotransposition
Authors: Christian Claiborne M , Sokolowski Mark , deHaro Dawn , Kines Kristine J , Belancio Victoria P 
Published: January 2017

Abstract
Long interspersed element 1 (L1) is the only currently active autonomous retroelement in the human genome. Along with the parasitic SVA and short interspersed element Alu, L1 is the source of DNA damage induced by retrotransposition: a copy-and-paste process that has the potential to disrupt gene function and cause human disease. The retrotransposition process is dependent upon the ORF2 protein (ORF2p). However, it is unknown whether most of the protein is important for retrotransposition. In particular, other than the Cys motif, the C terminus of the protein has not been intensely examined in the context of retrotransposition. Using evolutionary analysis and the Alu retrotransposition assay, we sought to identify additional amino acids in the C terminus important for retrotransposition. Here, we demonstrate that Gal4-tagged and untagged C-terminally truncated ORF2p fragments possess residual potential to drive Alu retrotransposition. Using sight-directed mutagenesis we identify that while the Y1180 amino acid is important for ORF2p- and L1-driven Alu retrotransposition, a mutation at this position improves L1 retrotransposition. Even though the mechanism of the contribution of Y1180 to Alu and L1 mobilization remains unknown, experimental evidence rules out its direct involvement in the ability of the ORF2p reverse transcriptase to generate complementary DNA. Additionally, our data support that ORF2p amino acids 1180 and 1250–1262 may be involved in the reported ORF1p-mediated increase in ORF2p-driven Alu retrotransposition.
Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire
Authors: Borgen Melissa , Rowland Kimberly , Boerner Jana , Lloyd Brandon , Khan Aruna , Murphey Rodney 
Published: January 2017

Abstract
The ubiquitin ligase Highwire has a conserved role in synapse formation. Here, we show that Highwire coordinates several facets of central synapse formation in the Drosophila melanogaster giant fiber system, including axon termination, axon pruning, and synaptic function. Despite the similarities to the fly neuromuscular junction, the role of Highwire and the underlying signaling pathways are distinct in the fly’s giant fiber system. During development, branching of the giant fiber presynaptic terminal occurs and, normally, the transient branches are pruned away. However, in highwire mutants these ectopic branches persist, indicating that Highwire promotes axon pruning. highwire mutants also exhibit defects in synaptic function. Highwire promotes axon pruning and synaptic function cell-autonomously by attenuating a mitogen-activated protein kinase pathway including Wallenda, c-Jun N-terminal kinase/Basket, and the transcription factor Jun. We also show a novel role for Highwire in non-cell autonomous promotion of synaptic function from the midline glia. Highwire also regulates axon termination in the giant fibers, as highwire mutant axons exhibit severe overgrowth beyond the pruning defect. This excessive axon growth is increased by manipulating Fos expression in the cells surrounding the giant fiber terminal, suggesting that Fos regulates a trans-synaptic signal that promotes giant fiber axon growth.
Actualización de la prueba general para la evaluación del desarrollo integral del niño entre los 0 meses y 6 años de edad (EDIN)
Authors: González-Serrano Sunny , Brenes-Monge Alexander , Fernández Simpsom Claudia , Mata Avila Marlon , Bustos ​Alfaro Elena 
Published: January 2017

Introducción: En este artículo se presentan los resultados obtenidos en la actualización de la prueba general para la evaluación del desarrollo integral del niño y la niña entre los 0 y 6 años de edad (EDIN).Metodología: la metodología fue de carácter cualitativo, transversal y descriptivo. Se contó con la participación de 14 expertos en el área del desarrollo humano. Los datos fueron recolectados mediante la técnica de juicio de expertos de tipo agregados individuales; la información obtenida fue triangulada con evidencia científica actualizada para determinar la permanencia de los ítems en la propuesta actualizada.Resultados: La prueba juicio de expertos permitió confirmar la inconsistencia de algunos ítems, por lo que fue necesario cambiar, eliminar y adecuar ítems del EDIN. Del total de 456 ítems de esta prueba, 72 (16%) del área de “hábitos”, fueron excluidos, por no corresponder a un área del desarrollo, 127 (27.9%) fueron inconsistentes , 257 (56%) fueron consistentes y se crearon 15 nuevos ítems, lo cual da como resultado una prueba actualizada con 287 ítems, distribuidos en seis áreas del desarrollo y 19 grupos de edad, más una lista de cotejo compuesta por 112 recomendaciones sobre los patrones de alimentación, sueño y descanso, eliminación, higiene y vestido y seguridad.Conclusiones: La investigación aporta una prueba actualizada para la población infantil costarricense menor de seis años. El estudio de las pruebas de evaluación del desarrollo es necesario para la atención integral durante la infancia, por lo que es importante que el país cuente con instrumentos de evaluación del desarrollo propios y actualizados.
Highly conductive and transparent Ti-doped zinc oxide thin films
Authors: Lu Yang-Ming , Tsai Shu-I , Chang Chen-Min 
Published: January 2017

AbstractThe properties of ZnO thin film are currently of great commercial and scientific interest due to its particular properties such as highly conductive, transparent as well as chemical stability and nontoxic. The Ti doping ZnO thin films were deposited by simultaneously magnetron co-sputtering from both Zn and Ti targets in a mixture of oxygen and argon gases onto heated Corning 7059 glass substrates in this study. The experimental results show that deposition rate of ZnO films are strongly dependent on DC power of Ti target. The growth rate initially increases and changes to decrease when the DC power of Ti target further rises. The content of Ti in the ZnO films increases with the applied DC power of Ti target. The lattice constant of ZnO (002) increases with DC power of Ti target due to incorporated Ti into the lattice of ZnO. The crystalline size becomes smaller when the DC power of Ti target was raised. The visible transmittance is a little lowered when slight Ti incorporated but still average maintains above 80%. The lowest resistivity of undoped ZnO film obtained in this study is 4.14×10-3 ohm-cm and further decreased to 1.02×10-3 ohm-cm after being doped a trace of Ti.
Evaluation of the results endonasal dacrocystorhinostomy in patients with DCR
Authors: Vaghela Mukund , Patel Alpesh , Patel Vaibhav , Dhanani Ankur 
Published: January 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Dacrocystitis refers to a series of clinical entities characterized by inflammation of lacrimal sac which leads to obstruction at the level of drainage of lacrimal system. Owing to the initial encouraging results and simplicity of the operation, it is decided that all symptomatic patients with lacrimal drainage obstruction would be treated initially by endoscopic endonasal dacrocystorhinostomy method, irrespective of the level of obstruction. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A total 50 patients were included in the study over a period of 3-4 months. They were subjected to endonasal dacrocystorhinostomy and were evaluated for postoperative complications. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Very few complications were seen postoperatively suggesting that this newer technique may be useful. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Endonasal dacrocystorhinostomy may prove better in coming years.</span></p>
Vozes ameríndias na universidade pública inclusiva / Amerindian voices in inclusive public university
Authors: Godoy Daniela Bueno de Oliveira Américo de , Bairrão José Francisco Miguel Henriques 
Published: January 2017

A lei de cotas é um marco rumo à universidade pública inclusiva. Todavia, seu modelo pode não contemplar especificidades culturais. O objetivo deste trabalho é apresentar vozes indígenas sobre o assunto. Visa-se dar ouvidos às comunidades e lideranças indígenas no acompanhamento dessa política. Utilizou-se uma abordagem qualitativa, própria à etnopsicologia, que consistiu em explicitar comparações implícitas entre as culturas ameríndias e a ocidental. Analisaram-se as falas de palestrantes indígenas nas três edições do Encontro Nacional dos Estudantes Indígenas (ENEI). Os resultados mostram que acessar o ensino superior é uma estratégia política e que o território é o principal articulador conceitual. A universidade é vivida de modo peculiar, sem necessariamente corresponder aos moldes da formação ocidental. Os contrastes epistemológicos, pedagógicos e ontológicos por eles evidenciados sustentam propostas em direção à intercientificidade e à interculturalidade (CAPES).Palavras-chave: indígenas, políticas de ações afirmativas, ensino superior, etnopsicologia. ABSTRACT: The Quota Law is a milestone towards inclusive public university. However, this model may not contemplate cultural specificities. This paper aims to present Amerindian voices about this subject by listening to communities and indigenous leaders in monitoring this policy. We used a qualitative approach specific to Ethnopsychology methodology which consists of explicit implicit comparisons between the Amerindian cultures and Western cultures. The speeches of indigenous speakers in the three editions of the National Indigenous Students Meeting were analyzed. The results show that the access to higher education is a political strategy and that the territory is the main conceptual articulator. The university is experienced in a special way, without necessarily matching to the mold of Western education. The epistemological, pedagogical and ontological contrasts highlighted by them support proposals towards interscientism and interculturalism.Keywords: Indigenous people, affirmative action, higher education, ethnopsychology.
Sickle Cell Trait and Renal Function in Hispanics in the United States: the Northern Manhattan Study
Authors: Dueker Nicole D. , Della-Morte David , Rundek Tatjana , Sacco Ralph L. , Blanton Susan H. 
Published: January 2017

<p class="Pa7">Sickle cell anemia (SCA) is a common hematological disorder among individu­als of African descent in the United States; the disorder results in the production of abnormal hemoglobin. It is caused by homozygosity for a genetic mutation in HBB; rs334. While the presence of a single mutation (sickle cell trait, SCT) has long been considered a benign trait, recent research suggests that SCT is associated with renal dysfunction, including a decrease in estimated glomerular filtration rate (eGFR) and increased risk of chronic kidney disease (CKD) in African Americans. It is currently unknown whether similar associations are observed in Hispanics. Therefore, our study aimed to determine if SCT is associated with mean eGFR and CKD in a sample of 340 Dominican Hispanics from the Northern Manhattan Study. Using regression analyses, we tested rs334 for association with eGFR and CKD, adjusting for age and sex. eGFR was estimated using the Chronic Kidney Disease Epidemiology Collaboration equa­tion and CKD was defined as eGFR &lt; 60 mL/min/1.73 m2. Within our sample, there were 16 individuals with SCT (SCT carriers). We found that SCT carriers had a mean eGFR that was 12.12 mL/min/1.73m2 lower than non-carriers (P=.002). Additionally, SCT carriers had 2.72 times higher odds of CKD compared with non-carriers (P=.09). Taken together, these novel results show that Hispanics with SCT, as found among African Americans with SCT, may also be at increased risk for kidney disease.</p><p class="Pa7"><em>Ethn Dis. </em>2017; 27(1)<strong>:</strong>11-14; doi:10.18865/ed.27.1.11.</p><p class="Pa7"> </p>
Rodolfo Stavenhagen e a sociologia do subdesenvolvimento: colonialismo, classes sociais e estratificação interétnica
Authors: Costa Diogo Valença de Azevedo 
Published: January 2017

O objetivo deste artigo é apresentar o esforço de conceituação das classes sociais nas sociedades subdesenvolvidas, avançado por Rodolfo Stavenhagen nos idos dos anos de 1960. Também serão consideradas suas formulações rela- tivas às características da situação colonial nos países subdesenvolvidos, for- temente permeadas pela estratificação interétnica e por suas influências sobre as situações de classe. Dois de seus mais notórios textos serão tomados como objeto de análise, Las clases sociales en las sociedades agrarias (1969), e suas Sete teses equivocadas sobre América Latina, pela primeira vez publicadas em 1965. Por fim, as ideias de Stavenhagen serão contrastadas com algumas das reflexões sociológicas, políticas e teóricas sobre o colonialismo, as classes sociais e as relações interétnicas produzidas no Brasil.
La Revocatoria de Mandato en Venezuela y su diseño institucional: el caso Hugo Chávez (2004)
Authors: Eberhardt Maria Laura 
Published: January 2017

Desde los 80 varios países latinoamericanos ejecutaron reformas constitucio- nales donde incorporaron la revocatoria de mandato entre otros mecanismos de democracia directa. Esta herramienta permite a los ciudadanos destituir representantes electos a través de un referéndum. Venezuela la incorporó en 1999 alcanzando incluso al presidente y la aplicó en 2004 contra Chávez. Este trabajo analiza el diseño institucional de la revocatoria en ese país para dilu- cidar su aplicabilidad y posibles efectos sobre el régimen presidencial, indaga su potencial y sus limitaciones como vía de salida institucional frente a crisis de legitimidad de los representantes, detecta posibles usos indebidos del me- canismo por grupos con pretensiones electoralistas anticipadas, y examina su potencial y efectos para los regímenes democráticos de la región.
Fusão, tensão e dissensão: forças de configuração da intimidade reflexiva
Authors: Sacramento Octávio 
Published: January 2017

A intimidade pós-moderna constitui uma esfera estruturalmente marcada pela complexa convivência de disposições sociais de dissensão e de fusão. Por um lado, é permeada por condições propícias à individualização, à re- flexividade e à electividade, o que contribui para reforçar idiossincrasias e aspirações pessoais nas relações íntimas. Por outro lado, encontra-se simbo- licamente colonizada pela grande narrativa romântica, uma matriz cultural muito valorizada e desejada, que impulsiona os sujeitos no sentido da fusão passional. Delineado num formato ensaístico, o artigo assume como objecto de análise central as manifestações de forças antagónicas na configuração da intimidade, procurando compreender as muitas tensões, ambiguidades, con- tradições e volatilidades que tendem a caracterizá-la.
Diálogos entre Chantal Mouffe e Pierre Bourdieu: uma proposta de análise sociológica da ação dos trabalhos artísticos no interior do campo da arte a partir do conceito de agenciamentos artísticos
Authors: Cavalcanti Raíza 
Published: January 2017

Neste artigo apresento uma proposta teórico-metodológica para a análise de trabalhos artísticos desde a perspectiva da sociologia, baseada nas teorias de campo de Pierre Bourdieu e de democracia agonista de Chantal Mouffe. A partir do conceito de agenciamentos artísticos, proponho uma análise das relações entre os processos de legitimação (e a potencial apropriação da crí- tica que geram) observando a ação dos trabalhos artísticos no interior das instituições e instâncias legitimadoras que participam. Ao centrar o foco na agência dos trabalhos artísticos e suas práticas estético-discursivas no interior do campo da arte, pretende-se ver mais de perto sua atuação quando imersos em bienais, feiras de arte, participando do mercado e de textos institucionais. Uma microanálise da ação dos trabalhos artísticos no interior do campo da arte é o objetivo principal que se pretende atingir ao aplicar-se o conceito de agenciamentos artísticos.
A noção de dever como categoria sociológica para a compreensão de ações no mundo contemporâneo
Authors: Guerrini Daniel 
Published: January 2017

O artigo se inscreve na temática da sociologia da ética. O objetivo é delimitar a noção de dever como categoria sociológica, recurso heurístico para a análise da capacidade de julgamento ético de agentes sociais. Investiga-se como se molda essa capacidade nas sociedades capitalistas contemporâneas, cultural e socialmente racionalizadas O caminho para tanto é a discussão sobre a per- sonalidade social na sociologia weberiana, que se define por uma consistência na relação entre valores e ação. Conclui-se que a noção de dever é importante para entender essa relação, expondo a maneira como os agentes sociais es- tabelecem compromissos valorativos nas diversas esferas da vida social e as consequências que isso tem para o curso efetivo de sua ação no mundo.
À meia-noite levarei sua alma: cinema, modernidade e dominação
Authors: De Andrade Ícaro Yure Freire 
Published: January 2017

Este artigo analisa os elementos estéticos, históricos e morais presentes no filme À meia-noite levarei sua alma de José Mojica Marins, enfatizando os elementos abjetos assim como as ações de seu protagonista - o coveiro Zé do Caixão. Entretanto, o principal foco da análise é apontar a importância do cinema de horror e dos recursos estilísticos adotados pelo mesmo para os estudos sociais. Portanto, buscou-se demonstrar como o gênero de horror traz em seu interior tensões e dilemas próprios às sociedades em que foram produzidos, de modo que, a partir de seu núcleo, podemos entender os pro- blemas das próprias sociedades que se reconhecem enquanto modernas ou perseguem um projeto de modernização.