bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Global View of Coastal Low-Level Wind Jets Using an Ensemble of Reanalyses
Authors: Lima Daniela C. A. , Soares Pedro M. M. , Semedo Alvaro , Cardoso Rita M. 
Published: December 2017

AbstractGlobal reanalyses are powerful tools to study the recent climate. They are built by combining forecast models with observations through data assimilation, which provide complete spatial and temporal information of observable and unobservable parameters. The reanalyses constitute very valuable three-dimensional data of the atmosphere, which make it possible to investigate a panoply of atmospheric processes, such as coastal low-level jets (CLLJs). In the present study, three global reanalyses, the European Centre for Medium-Range Weather Forecasts (ECMWF) interim reanalysis (ERA-Interim), the Japanese 55-year Reanalysis (JRA-55), and the Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), are used to build an ensemble of reanalyses for a period encompassing 1980–2016 with 6-hourly output. A detailed global climatology of CLLJs is presented based on this ensemble of reanalyses. This reanalysis ensemble makes it possible to explore the ability of reanalysis to represent the CLLJs mitigating its uncertainty and adding robustness. The annual and diurnal cycle as well as the interannual variability are analyzed in order to evaluate the temporal variability of frequency of occurrence of CLLJ. The ensemble mean displays a good representation of the seasonal spatial variability of frequency of occurrence of coastal jets. The Oman and Benguela CLLJs show, respectively, a decrease and increase of frequency of occurrence in the studied period, which are statistically significant during boreal summer and austral spring. The coastal jets have higher mean frequencies of occurrences during late afternoon and early evening. During the season where each CLLJ has higher mean frequency of occurrence, the Oman CLLJ is the most intense and occurs at higher altitudes.
Effect of Transcranial Direct Current Stimulation in Patients With Tinnitus: A Meta-Analysis and Systematic Review
Authors: Wang Tang-Chuan , Tyler Richard S. , Chang Ta-Yuan , Chen Jui-Cheng , Lin Chia-Der , Chung Hsiung-Kwang , Tsou Yung-An 
Published: December 2017

Objectives: Subjective tinnitus is a phantom sensation experienced without any external source of sound that profoundly impacts the quality of life. Some investigations have claimed that transcranial direct current stimulation (tDCS) reduces tinnitus, but studies on tDCS have demonstrated variable results. This meta-analysis aimed to examine the effect of tDCS on patients with tinnitus. Methods: We searched for articles published through January 5, 2016, in Medline, Cochrane, EMBASE, and Google Scholar using the following keywords: tinnitus, transcranial direct current stimulation, and tDCS. The study outcomes were change in magnitude estimates of loudness (loudness), tinnitus-related distress (distress), and Tinnitus Handicap Inventory (THI). Results: Pooled results demonstrated that tDCS did not have a beneficial effect on loudness (pooled standardized difference in means = 0.674, 95% CI, –0.089 to 1.437, P = .083). Further, the pooled results demonstrated a greater reduction in distress for the tDCS group (pooled standardized difference in means = 0.634, 95% CI, 0.021-1.247, P = .043). Conclusions: We conclude that the pooled results demonstrated a greater reduction in distress for groups treated with tDCS as compared with those administered a sham treatment.
Effects of Anthropometric Variables and Seat Height on Automobile Drivers’ Preferred Posture With the Presence of the Clutch
Authors: Peng Junfeng , Wang Xuguang , Denninger Lisa 
Published: December 2017

Objective The effects of seat height and anthropometric dimensions on drivers’ preferred postures were investigated using a multiadjustable vehicle mock-up with a large number of adjustments and extended ranges. Background Many studies have been conducted on preferred driving posture under different test conditions showing mixed and even contradictory findings. No studies thus far have considered the clutch and compared Chinese and European drivers. Method Four seat height conditions were tested: free and three imposed heights (250, 300, and 350 mm). Sixty-one subjects (40 French-born and 21 Chinese-born) participated in the experiment, covering a large range of stature and sitting height–to–stature ratio. The RAMSIS kinematic model was used to reconstruct postures, and main intersegmental angles were extracted for characterizing posture. Results Under the free seat height condition, no significant differences in preferred intersegmental angles were observed between different participant groups. Seat height mainly affected trunk–thigh angle, whereas it had almost no effect on trunk orientation and other intersegmental angles. Chinese participants sat more forward in the seat, leading to a more opened trunk–thigh angle and a more reclined trunk. Conclusions Results suggest that intersegmental angles of preferred posture are not dependent on anthropometric dimensions, although shorter drivers prefer a slightly less reclined trunk. Self-selected driving posture results from a compromise between maintaining the intersegmental angles in one’s preferred range and a preferred trunk orientation in space. Applications The findings contribute to a better understanding of preferred driving postures and would be helpful for improving vehicle interior design.
Disputatiousness and the Offender–Victim Overlap
Authors: Felson Richard B. , Berg Mark T. , Rogers Ethan M. , Krajewski Andrew 
Published: December 2017

Objectives: We examine whether offenders are at greater risk of violent victimization than non-offenders because of their disputatiousness; that is, their tendency to become involved in verbal conflicts. We also examine whether offenders are more disputatious because of their low self-control, alcohol use, and honor-based attitudes and whether disputatiousness can explain the effects of these individual differences on violent victimization. Method: A series of regression models examine self-reported data from 503 male inmates and 220 men ( N = 723) they know from the community who have never been arrested. Results: Disputatiousness accounts for a substantial portion of the relationship between victimization and offending (i.e., inmate status). Disputatiousness also mediates the relationships between victimization and frequent intoxication, low self-control, and honor-based attitudes. Low self-control and heavy alcohol use account for a substantial portion of the relationship between offending and disputatiousness. Disputatiousness and victimization are associated with a history of assaultive offenses but not a history of robbery. Conclusions: The tendency to become involved in verbal conflicts can partly explain high victimization rates among male offenders, and among men who lack self-control, are frequently intoxicated, and have strong concerns about protecting their honor.
Lengthening Temporalis Myoplasty: Objective Outcomes and Site‐Specific Quality‐of‐Life Assessment
Authors: Panciera Davide Thomas , Sampieri Claudio , Deganello Alberto , Danesi Giovanni 
Published: December 2017

ObjectiveEvaluate outcomes of the lengthening temporalis myoplasty in facial reanimations.Study DesignCase series with planned data collection.SettingOspedali Riuniti, Bergamo, and AOUC Careggi, Florence, Italy.Subjects and MethodsFrom 2011 to 2016, 11 patients underwent lengthening temporalis myoplasty; demographic data were collected for each. Pre‐ and postoperative photographs and videos were recorded and used to measure the smile angle and the excursion of the oral commissure, according to the SMILE system (Scaled Measurements of Improvement in Lip Excursion). All patients were tested with the Facial Disability Index, and they also completed a questionnaire about the adherence to physiotherapy indications.ResultsAll patients demonstrated a significant improvement in functional parameters and in quality of life. On the reanimated side, the mean z‐line and a‐value, measured when smiling, significantly improved in all patients: from 22.6 mm (95% CI, 20.23‐25.05) before surgery to 30.9 mm (95% CI, 27.82‐33.99) after surgery (P <. 001) and from 100.5° (95% CI, 93.96°‐107.13°) to 111.6° (95% CI, 105.63°‐117.64°; P <. 001), respectively. The mean postoperative dynamic gain, passing from rest to a full smile at the reanimated side, was 3.1 mm (95% CI, 1.30‐4.88) for the z‐line and 3.3° (95% CI, 1.26°‐5.29°) for the a‐value. The Facial Disability Index score increased from a preoperative mean of 33.4 points (95% CI, 28.25‐38.66) to 49.9 points (95% CI, 47.21‐52.60) postoperatively (P <. 001).ConclusionsThe lengthening temporalis myoplasty can be successfully used for smile reanimation, with satisfying functional and quality‐of‐life outcomes.
From Surveys to Management
Authors: Bhattacharya Ujjayan 
Published: December 2017

Flood management and embankment maintenance were responsibilities of the state and the social institutions for many centuries. But as the colonial state was based on an epistemic foundation different from the previous regimes, the period witnessed the creation of a new institutional order which resulted in close collaboration between the institution of surveys and the administration of inland water management. As a result, the colonial intervention was characterised by deployment of a corps of engineers who used the knowledge gathered from surveys for managing the water channels and their banks. The process witnessed the establishment of a branch of the military devoted to engineering work in the colonies where supervision and intervention by European experts became an essential feature. The early colonial rule in itself was in a process of transformation: from a commercial/mercantile entity to a fiscal-military state. It was also a state which was establishing a routinised bureaucracy. How both these developments were reflected on the institutions of water management is a central concern of this study. The subordination of the traditional agency in these developments is an important question.
In vivo study on biodegradable magnesium alloys: Bone healing around WE43 screws
Authors: Levorova Jitka , Duskova Jaroslava , Drahos Milan , Vrbova Radka , Vojtech D , Kubasek Jiri , Bartos Martin , Dugova Lenka , Ulmann Dan , Foltan Rene 
Published: December 2017

Introduction A standard osteosynthetic material for maxillofacial skeleton is titanium and its alloys. The convenience of degradable material is avoiding of second surgery in cases, where removal of the material is necessary. Magnesium biodegradable alloys have similar mechanic properties as cortical bone – reasonable corrosion and sufficient biologic properties. They might be used in facial skeleton fixation. Materials and methods The study included a total of 16 rabbits, and they were randomly divided into two groups. Each group received two screws (WE4 and titanium as a standard material) in artificially drilled defect into right tibia. Animals were euthanized at four-week intervals. Bone samples with implants underwent microfocus CT scans and were histologically examined. Results WE43 alloys showed fragmentation of the material on the 16th week – statistically significant volume loss was found between weeks 12 and 16. Bone healing around the WE43 screws was of similar quality as around titanium screws, and no adverse effect was noticed. Conclusion The study showed good quality of bone healing around WE43 implants. From this point of view, the WE43 alloy meets the requirements of osteosynthetic material for maxillofacial skeleton.
Cardiovascular, respiratory and sedative effects of intramuscular alfaxalone, butorphanol and dexmedetomidine compared with ketamine, butorphanol and dexmedetomidine in healthy cats
Authors: Cremer Jeannette , Riccó Carolina H 
Published: December 2017

Objectives The aim of the study was to evaluate the cardiorespiratory effects, quality of sedation and recovery of intramuscular alfaxalone–dexmedetomidine–butorphanol (ADB) and ketamine–dexmedetomidine–butorphanol (KDB), in cats. Methods Nine adult, healthy cats (6.63 ± 1.42 kg) were enrolled in a blinded, randomized, crossover experimental design. Cats were sedated twice intramuscularly, once with ADB (alfaxalone 1 mg/kg, dexmedetomidine 0.005 mg/kg, butorphanol 0.2 mg/kg), and once with KDB (ketamine 5 mg/kg, dexmedetomidine 0.005 mg/kg, butorphanol 0.2 mg/kg), in random order. Data collected included heart rate (HR), arterial blood pressure and blood gas analysis, respiratory rate and sedation score. Analysis of variance with Bonferroni post-hoc correction was used for parametric data, and a Wilcoxon signed rank test was used for non-parametric data. Significance was set at P <0.05. Results Total sedation time was shorter for ADB (90.71 ± 15.12 mins vs 147.00 ± 47.75 mins). Peak sedation was observed within 15 mins in both groups. Quality of recovery was excellent in both groups. HR decreased over time in both groups. Diastolic and mean arterial pressure decreased over time for ADB, becoming significant after 30 mins. All cardiovascular variables were within the clinically acceptable range in both groups. Arterial partial pressure of oxygen was significantly decreased from baseline for KDB at all time points (73 ± 2.5 mmHg [9.7 ± 0.3 kPa] vs ADB 83 ± 2.6 mmHg [11 ± 0.3 kPa]). Hypoventilation was not observed. Conclusions and relevance Both protocols produced acceptable cardiovascular stability. Sedation and recovery quality were good, albeit sedation was shorter with ADB. Although oxygenation was better maintained in the ADB group, all sedated cats should receive oxygen supplementation.
What does it take to change practice? Perspectives of pharmacists in Ontario
Authors: Gregory Paul A. M. , Teixeira Beatriz , Austin Zubin 
Published: December 2017

Background: This is a time of rapid change in the profession of pharmacy. Anecdotally, there are concerns that the pace, extent and rate of practice evolution are lagging. There is little evidence documenting the influencers and mechanisms that drive practice changes forward in pharmacy in Canada. Methods: An exploratory qualitative method was selected, using both one-on-one interviews with self-categorized typical pharmacists and larger focus groups to provide context and confirmation of themes generated through interviews. Data were analyzed and coded using a constant-comparative iterative method, in order to generate themes related to the factors influencing pharmacists to actually change their practice. Results: A total of 46 pharmacists meeting inclusion criteria participated in this study in focus groups, interviews or both. Nine themes were identified: 1) permission, 2) process pointers, 3) practice/rehearsal, 4) positive reinforcement, 5) personalized attention, 6) peer referencing, 7) physician acceptance, 8) patients’ expectations and 9) professional identity supportive of a truly clinical role. One theme that did not emerge was payment, or remuneration, as a specific or isolated motivational factor for change. Interpretation: The complexity of practice change in pharmacy and the multiple factors highlighted in this study point to a more deliberate and concerted effort being needed by diverse pharmacy organizations (educators, regulators, employers, professional associations, etc.) to support pharmacists through the change management process. Conclusions: The “9 Ps of practice change” identified through this study can provide pharmacists with guidance in terms of how to better support evolution of the profession in a more time-efficient and effective manner.
Incidence of first stroke and ethnic differences in stroke pattern in Bradford, UK: Bradford Stroke Study
Authors: Ramadan Hawraman , Patterson Chris , Maguire Stuart , Melvin Ian , Kain Kirti , Teale Elizabeth , Forster Anne 
Published: December 2017

Background Information on ethnic disparities in stroke between White and Pakistani population in Europe is scarce. Bradford District has the largest proportion of Pakistani people in England; this provides a unique opportunity to study the difference in stroke between the two major ethnic groups. Aim To determine the first-ever-stroke incidence and examine the disparities in stroke patterns between Whites and Pakistanis in Bradford. Methods Prospective 12 months study consisting of 273,327 adults (≥18 years) residents. Stroke cases were identified by multiple overlapping approaches. Results In the study period, 541 first-ever-strokes were recorded. The crude incidence rate was 198 per 100,000 person-years. Age adjusted-standardized rate to the World Health Organization world population of first-ever-stroke is 155 and 101 per 100,000 person-years in Pakistanis and Whites respectively. Four hundred and thirty-eight patients (81%) were Whites, 83 (15.3%) were Pakistanis, 11 (2%) were Indian and Bangladeshis, and 9 (1.7%) were of other ethnic origin. Pakistanis were significantly younger and had more obesity ( p = 0.049), and diabetes mellitus (DM) ( p = <0.001). They were less likely to suffer from atrial fibrillation ( p = <0.001), be ex- or current smokers ( p = <0.001), and drink alcohol above the recommended level ( p = 0.007) compared with Whites. In comparison with Whites, higher rates of age-adjusted stroke (1.5-fold), lacunar infarction (threefold), and ischemic infarction due to large artery disease (twofold) were found in the Pakistanis. Conclusions The incidence of first-ever-stroke is higher in the Pakistanis compared with the Whites in Bradford, UK. Etiology and vascular risk factors vary between the ethnic groups. This information should be considered when investigating stroke etiology, and when planning prevention and care provision to improve outcomes after stroke.
Orthopaedic Sports Medicine Fellowship Interviews: Structure and Organization of the Interview Day
Authors: Haislup Brett D. , Kraeutler Matthew J. , Baweja Rishi , McCarty Eric C. , Mulcahey Mary K. 
Published: December 2017

Background: Over the past few decades, there has been a trend toward an increasing subspecialization in orthopaedic surgery, with orthopaedic sports medicine being one of the most competitive subspecialties. Information regarding the application and interview process for sports medicine fellowships is currently lacking. Purpose: To survey orthopaedic sports medicine fellowship program directors (PDs) to better define the structure of the sports medicine fellowship interview and to highlight important factors that PDs consider in selecting fellows. Study Design: Cross-sectional study. Methods: A complete list of accredited programs was obtained from the American Orthopaedic Society for Sports Medicine (AOSSM) website. An anonymous survey was distributed to fellowship PDs of all Accreditation Council for Graduate Medical Education (ACGME)–accredited orthopaedic sports medicine fellowships in the United States. The survey included 12 questions about the fellowship interview and selection process. Results: Of the 95 orthopaedic sports medicine fellowship PDs surveyed, 38 (40%) responded. Of these, 16 (42.1%) indicated that they interview between 21 and 30 applicants per year. Eleven of the 38 fellowship programs (28.9%) have only 1 fellow per year at their respective program. Most programs (27/37, 73%) reported that between 0 and 5 faculty members interview applicants, and 29 of the 38 programs (76.3%) arrange for applicants to have ≥4 interviews during their interview day. Large group interviews are conducted at 36 of 38 (94.7%) sports medicine fellowship programs, and most programs (24/38, 63.2%) hold individual interviews that last between 5 and 15 minutes. The most important applicant criterion taken into account by PDs was the quality of the interview, with an average score of 8.68 of 10. Conclusion: The most significant factor taken into account by PDs when deciding how to rank applicants was the quality of the interview. Many orthopaedic sports medicine fellowship programs interview between 21 and 30 applicants per year, with each applicant participating in an average of 2 to 4 individual interviews per interview day and interviews commonly lasting between 5 and 15 minutes.
Circadian mood variations in Twitter content
Authors: Dzogang Fabon , Lightman Stafford , Cristianini Nello 
Published: December 2017

Background: Circadian regulation of sleep, cognition, and metabolic state is driven by a central clock, which is in turn entrained by environmental signals. Understanding the circadian regulation of mood, which is vital for coping with day-to-day needs, requires large datasets and has classically utilised subjective reporting. Methods: In this study, we use a massive dataset of over 800 million Twitter messages collected over 4 years in the United Kingdom. We extract robust signals of the changes that happened during the course of the day in the collective expression of emotions and fatigue. We use methods of statistical analysis and Fourier analysis to identify periodic structures, extrema, change-points, and compare the stability of these events across seasons and weekends. Results: We reveal strong, but different, circadian patterns for positive and negative moods. The cycles of fatigue and anger appear remarkably stable across seasons and weekend/weekday boundaries. Positive mood and sadness interact more in response to these changing conditions. Anger and, to a lower extent, fatigue show a pattern that inversely mirrors the known circadian variation of plasma cortisol concentrations. Most quantities show a strong inflexion in the morning. Conclusion: Since circadian rhythm and sleep disorders have been reported across the whole spectrum of mood disorders, we suggest that analysis of social media could provide a valuable resource to the understanding of mental disorder.
DNA and factor VII–activating protease protect against the cytotoxicity of histones
Authors: Marsman Gerben , von Richthofen Helen , Bulder Ingrid , Lupu Florea , Hazelzet Jan , Luken Brenda M. , Zeerleder Sacha 
Published: December 2017

Key PointsFree histones, not nucleosomes, are cytotoxic and are degraded by FSAP in serum to protect against cytotoxicity. Free histone H3 was not detectable in sera of septic baboons and patients with meningococcal sepsis.
Severe COPD and the transition to a palliative approach
Authors: Landers Amanda , Wiseman Rachel , Pitama Suzanne , Beckert Lutz 
Published: December 2017

Patients with severe chronic obstructive pulmonary disease (COPD) have a chaotic trajectory towards death. Research has focused on identifying a “transition point” that would allow identification of those patients who may benefit from a palliative approach to their care, or referral to a specialist palliative care service. This article aims to outline difficulties in identifying this transition point, summarise current literature on this topic and suggests a model based on clinical milestones.Educational aimsTo outline the difficulties associated with identifying patients with severe COPD who are at risk of dying.To summarise current research on this topic.Key pointsA specific transition point is difficult to identify in severe COPD.Tools are available that may assist the physician in identifying those at risk of dying.It is essential that the patient voice is heard, patients can describe specific events that may be used as a “trigger” for a palliative approach.Specialist palliative care services may only be required for a subgroup of patients whose needs cannot be managed by the primary care team.