bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfusion Index in Very Low Birth Weight Premature Infants During Their First 2 Weeks of Life
Authors: Knobel-Dail Robin B. , Tanaka David T. , Holditch-Davis Diane , White John 
Published: June 2016

Background: Our program of research focuses on thermal and circulatory stability in extremely premature infants. In prior studies, we found that infants have long periods of time in which foot temperature (FT) is higher than central temperature. We thus wanted to determine whether blood flow in the foot is increased when FT is elevated. Perfusion index (PI) can be used as a clinical indicator of peripheral perfusion, but reports on use of PI in premature infants are lacking. We employed exploratory methodology to examine foot perfusion and temperature in very low birth weight infants. Aims: For premature infants after birth: (1) describe foot PI values for the first 2 weeks of life and (2) describe the relationship of longitudinal FT and PI. Study Design: Case study design with longitudinal FT and PI in 17 infants born at <29 weeks’ gestation with birth weight < 1,200 g for 2 weeks after birth. Results: Infants averaged 851 g at birth and were 24–29 weeks’ gestational age. The mean PI across all infants for 14 days was 1.04, SD = 0.79. Using a repeated measures multilevel model approach confirmed that FT and PI were positively related in these infants. Conclusions: These findings demonstrate that perfusion is increased in the periphery in extremely premature infants when FT is increased. PI measures can be used as a trend for peripheral perfusion, and these values increase over the first 2 weeks of life in infants weighing more than 750 g.
Methodological reflections on research with street youth
Authors: Karabanow Jeff , Kidd Sean , Frederick Tyler , McLuckie Alan , Quick Jacqueline 
Published: June 2016

Summary This paper examines both the epistemological and practical limitations and challenges of data collection by reflecting on the experiences of a team of both junior and senior researchers engaged in such a longitudinal study. Findings This paper argues that longitudinal research with street youth challenges the boundaries and limits of the formal constructs of research and ethics that typically guide qualitative research by grappling with field issues such as navigating reciprocity, risk and authenticity within relationships with a vulnerable group. Application This paper calls for an explicit acknowledgement of the challenges researching populations such as street youth over time in our research ethics guidelines and encourages researchers to engage in dialogue leading to more reflective, transparent and accountable framing of how we collect data in the field with vulnerable youth populations.
Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia
Authors: Mahévas Matthieu , Gerfaud-Valentin Mathieu , Moulis Guillaume , Terriou Louis , Audia Sylvain , Guenin Sophie , Le Guenno Guillaume , Salles Gilles , Lambotte Olivier , Limal Nicolas , Viallard Jean-François , Cheze Stephane , Tomowiak Cecile , Royer Bruno , Neel Antoine , Debouverie Odile , Hot Arnaud , Durieu Isabelle , Perlat Antoinette , Cliquennois Manuel , Deteix Clémence , Michel Marc , Godeau Bertrand 
Published: June 2016

Key Points
The baseline characteristics of multirefractory ITP differed from “typical” ITP, outcome was severe, and was associated with high morbidity and mortality. Combining immunosuppressant therapy with a thrombopoietin-receptor agonist may be a relevant option for these patients.
The role of leukocytes in thrombosis
Authors: Swystun Laura L. , Liaw Patricia C. 
Published: June 2016

AbstractIn recent years, the traditional view of the hemostatic system as being regulated by a coagulation factor cascade coupled with platelet activation has been increasingly challenged by new evidence that activation of the immune system strongly influences blood coagulation and pathological thrombus formation. Leukocytes can be induced to express tissue factor and release proinflammatory and procoagulant molecules such as granular enzymes, cytokines, and damage-associated molecular patterns. These mediators can influence all aspects of thrombus formation, including platelet activation and adhesion, and activation of the intrinsic and extrinsic coagulation pathways. Leukocyte-released procoagulant mediators increase systemic thrombogenicity, and leukocytes are actively recruited to the site of thrombus formation through interactions with platelets and endothelial cell adhesion molecules. Additionally, phagocytic leukocytes are involved in fibrinolysis and thrombus resolution, and can regulate clearance of platelets and coagulation factors. Dysregulated activation of leukocyte innate immune functions thus plays a role in pathological thrombus formation. Modulation of the interactions between leukocytes or leukocyte-derived procoagulant materials and the traditional hemostatic system is an attractive target for the development of novel antithrombotic strategies.
Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients
Authors: Broekman Winifred , Roelofs Helene , Zarcone Maria C. , Taube Christian , Stolk Jan , Hiemstra Pieter S. 
Published: June 2016

Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) are evaluated for clinical use in chronic obstructive pulmonary disease (COPD) patients, but it is unclear whether COPD affects BM-MSCs.To investigate this, BM-MSCs from nine COPD patients and nine non-COPD age-matched controls were compared with regard to immunophenotype, growth and differentiation potential, and migration capacity. Other functional assays included the response to pro-inflammatory stimuli and inducers of the nuclear factor (erythroid derived 2)-like 2 antioxidant response element (Nrf2-ARE) pathway, and effects on NCI-H292 airway epithelial cells.No significant differences were observed in terms of morphology, proliferation and migration, except for increased adipocyte differentiation potential in the COPD group. Both groups were comparable regarding mRNA expression of growth factors and inflammatory mediators, and in their potential to induce mRNA expression of epidermal growth factor receptor ligands in NCI-H292 airway epithelial cells. MSCs from COPD patients secreted more interleukin-6 in response to pro-inflammatory stimuli. Activation of the Nrf2-ARE pathway resulted in a comparable induction of mRNA expression of four target genes, but the expression of the NAD(P)H:quinone oxidoreductase 1 geneNQO1was lower in MSCs from COPD patients.The observation that MSCs from COPD patients are phenotypically and functionally comparable to those from non-COPD controls implies that autologous MSCs can be considered for use in the setting of clinical trials as a treatment for COPD.
Cell surface proteins play an important role in probiotic activities of Lactobacillus reuteri
Authors: Singh Tejinder Pal , Malik Ravinder Kumar , Kaur Gurpreet 
Published: June 2016

Abstract
Background
Eight Lactobacillus reuteri strains, previously isolated from breast-fed human infant feces, were selected to assess the potential contribution of their surface proteins in probiotic activity. These strains were treated with 5 M LiCl to remove their surface proteins, and their tolerance to simulated stomach-duodenum passage, cell surface characteristics, autoaggregation, adhesion, and inhibition of pathogen adhesion to Caco-2 cells were compared with untreated strains.

Results
The survival rates, autoaggregation, and adhesion abilities of the LiCl-treated L. reuteri strains decreased significantly (p < 0.05) compared to that of the untreated cells. The inhibition ability of selected L. reuteri strains, untreated or LiCl treated, against adherence of Escherichia coli 25922 and Salmonella typhi NCDC113 to Caco-2 was evaluated in vitro with L. reuteri ATCC55730 strain as a positive control. Among the selected eight strains of L. reuteri, LR6 showed maximum inhibition against the E. coli ATCC25922 and S. typhi NCDC113. After treatment with 5 M LiCl to remove surface protein, the inhibition activities of the lactobacilli against pathogens decreased significantly (p < 0.05). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis indicated that LR6 strains had several bands with molecular weight ranging from 10 to 100 KDa, and their characterization and functions need to be confirmed.

Conclusions
The results revealed that the cell surface proteins of L. reuteri play an important role in their survivability, adhesion, and competitive exclusion of pathogen to epithelial cells.
Impact of anisotropic poroelastic parameters estimated using well logs and core measurements on stress prediction in organic-rich mudrocks
Authors: Valdes Clotilde Chen , Aderibigbe Aderonke , Heidari Zoya 
Published: June 2016

The evaluation of rock mechanical properties in organic-rich mudrocks is challenging because of their heterogeneity, anisotropy, and complex lithology. Hence, geomechanical analysis should include a complete definition of the anisotropic elastic stiffness coefficients for stress prediction. Furthermore, typical assumptions made for poroelastic parameters, such as assuming that Biot’s parameter is equal to one, can result in unreliable geomechanical evaluation for stress prediction and failure in completion design. Our objectives included estimating (1) anisotropic elastic properties and (2) anisotropic poroelastic parameters and minimum horizontal stresses, using laboratory measurements and well logs, in organic-rich mudrocks with different levels of mechanical anisotropy and vertical heterogeneity. We have performed mechanical tests on core plugs and obtained correlations between the dynamic and static elastic stiffness coefficients. We have analyzed advanced acoustic well logs, as well as laboratory geomechanical measurements, to estimate dynamic elastic stiffness coefficients of the formations under investigation. The estimates of mineral composition, in conjunction with the estimates of elastic stiffness coefficients, yielded the anisotropic poroelastic parameters. Finally, we have estimated the stress profile under the assumption of transverse isotropy. We have quantified the impact of anisotropic elastic rock properties and poroelastic parameters on stress prediction in the lower Eagle Ford, Haynesville, and upper Wolfcamp Formations. The estimated minimum horizontal stress gradient, assuming anisotropic elastic properties and anisotropic poroelastic parameters, varied by approximately 30% (relative difference) compared with the case in which these parameters were assumed to be equal to one. This variation decreased to approximately 15% and 6% when the poroelastic parameters were assumed to be equal to 0.7 in formations with high and relatively low levels of heterogeneity and mechanical anisotropy, respectively. The results confirmed that transversely isotropic media require a thorough depth-by-depth estimation of anisotropic poroelastic parameters to estimate stress profile accurately. We have also determined the importance of integrated interpretation of petrophysical, compositional, and mechanical properties in geomechanical evaluation in organic-rich mudrocks.
Nivolumab in Combination With Platinum‐Based Doublet Chemotherapy for First-Line Treatment of Advanced Non–Small-Cell Lung Cancer
Authors: Rizvi Naiyer A. , Hellmann Matthew D. , Brahmer Julie R. , Juergens Rosalyn A. , Borghaei Hossein , Gettinger Scott , Chow Laura Q. , Gerber David E. , Laurie Scott A. , Goldman Jonathan W. , Shepherd Frances A. , Chen Allen C. , Shen Yun , Nathan Faith E. , Harbison Christopher T. , Antonia Scott 
Published: June 2016

Purpose Nivolumab, a fully human immunoglobulin G4 programmed death-1 immune checkpoint inhibitor antibody, has demonstrated improved survival in previously treated patients with advanced non–small-cell lung cancer (NSCLC). CheckMate 012, a phase I, multicohort study, was conducted to explore the safety and efficacy of nivolumab as monotherapy or combined with current standard therapies in first-line advanced NSCLC. Here, we report results for nivolumab plus platinum-based doublet chemotherapy (PT-DC). Patients and Methods Patients (N = 56) received nivolumab (intravenously) plus PT-DC concurrently every 3 weeks for four cycles followed by nivolumab alone until progression or unacceptable toxicity. Regimens were nivolumab 10 mg/kg plus gemcitabine-cisplatin (squamous) or pemetrexed-cisplatin (nonsquamous) or nivolumab 5 or 10 mg/kg plus paclitaxel-carboplatin (all histologies). The primary objective was to assess safety and tolerability. Secondary objectives included objective response rate and 24-week progression-free survival rate (per Response Evaluation Criteria in Solid Tumors version 1.1); exploratory objectives included overall survival (OS) and response by tumor programmed death ligand-1 expression. Results No dose-limiting toxicities occurred during the first 6 weeks of treatment. Forty-five percent of patients (25 of 56 patients) reported grade 3 or 4 treatment-related adverse events (AEs); 7% of patients (n = 4) had pneumonitis. Twenty-one percent of patients (n = 12) discontinued all study therapy as a result of treatment-related AEs. Objective response rates for nivolumab 10 mg/kg plus gemcitabine-cisplatin, nivolumab 10 mg/kg plus pemetrexed-cisplatin, nivolumab 10 mg/kg plus paclitaxel-carboplatin, and nivolumab 5 mg/kg plus paclitaxel-carboplatin were 33%, 47%, 47%, and 43%, respectively; 24-week progression-free survival rates were 51%, 71%, 38%, and 51%, respectively; 2-year OS rates were 25%, 33%, 27%, and 62%, respectively. Responses were achieved regardless of tumor programmed death ligand-1 expression. Conclusion The safety profile of nivolumab plus PT-DC was consistent with that expected for individual agents; however, treatment discontinuation related to AEs was greater with the combination. Encouraging activity was observed, especially for the nivolumab 5 mg/kg plus paclitaxel-carboplatin group, with a 2-year OS rate of 62%.
Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels
Authors: Cunningham Glenn R. , Stephens-Shields Alisa J. , Rosen Raymond C. , Wang Christina , Bhasin Shalender , Matsumoto Alvin M. , Parsons J. Kellogg , Gill Thomas M. , Molitch Mark E. , Farrar John T. , Cella David , Barrett-Connor Elizabeth , Cauley Jane A. , Cifelli Denise , Crandall Jill P. , Ensrud Kristine E. , Gallagher Laura , Zeldow Bret , Lewis Cora E. , Pahor Marco , Swerdloff Ronald S. , Hou Xiaoling , Anton Stephen , Basaria Shehzad , Diem Susan J. , Tabatabaie Vafa , Ellenberg Susan S. , Snyder Peter J. 
Published: June 2016

Context:The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function.Objective:To assess the responsiveness of specific sexual activities to T treatment; to relate hormone changes to changes in sexual function; and to determine predictive baseline characteristics and T threshold for sexual outcomes.Design:A placebo-controlled trial.Setting:Twelve academic medical centers in the United States.Participants:A total of 470 men ≥65 years of age with low libido, average T &lt;275 ng/dL, and a partner willing to have sexual intercourse at least twice a month.Methods:Men were assigned to take T gel or placebo for 1 year. Sexual function was assessed by three questionnaires every 3 months: the Psychosexual Daily Questionnaire, the Derogatis Interview for Sexual Function, and the International Index of Erectile Function.Results:Compared with placebo, T administration significantly improved 10 of 12 measures of sexual activity. Incremental increases in total and free T and estradiol levels were associated with improvements in sexual activity and desire, but not erectile function. No threshold T level was observed for any outcome, and none of the 27 baseline characteristics predicted responsiveness to T.Conclusions:In older men with low libido and low T levels, improvements in sexual desire and activity in response to T treatment were related to the magnitude of increases in T and estradiol levels, but there was no clear evidence of a threshold effect.
Εξ Αποστάσεως Εκπαίδευση και εργαστηριακές δραστηριότητες στις Φυσικές Επιστήμες
Authors: ΓΕΩΡΓΙΑΔΗ Ειρήνη , ΚΟΚΚΑΛΗ Άννα 
Published: June 2016

Μια σημαντική ανησυχία στην εξ αποστάσεως εκπαίδευση είναι πώς να υπερνικήσει τα προβλήματα που συνδέονται με την εργαστηριακή άσκηση στις Φυσικές Επιστήμες. Σκοπός της εργασίας λοιπόν, είναι να παρουσιάσει τους τρόπους και τα εκπαιδευτικά μέσα που χρησιμοποιούν τα εξ αποστάσεως ανώτατα εκπαιδευτικά ιδρύματα, προκειμένου να επιτύχουν την εργαστηριακή εκπαίδευση των σπουδαστών τους, στις Φυσικές Επιστήμες. Στην εισήγηση αυτή τονίζεται η σημαντικότητα της παροχής εργαστηριακής άσκησης στους σπουδαστές των προγραμμάτων αυτών και περιγράφονται οι εναλλακτικοί τρόποι εργαστηριακής εκπαίδευσης. Τέλος επισημαίνονται τα πλεονεκτήματα και τα μειονεκτήματα των εναλλακτικών τρόπων εξ αποστάσεως εργαστηριακής εκπαίδευσης.
Η Αξιολόγηση των εκπαιδευτικών οργανισμών και ιδρυμάτων, η συστημική θεωρία και το Ελληνικό Ανοικτό Πανεπιστήμιο
Authors: ΧΟΥΛΙΑΡΑ Ξανθή 
Published: June 2016

<p>Κάθε ανθρώπινη δραστηριότητα, από την πιο απλή ως την πιο σύνθετη, περιλαμβάνει μια σειρά ενεργειών που σχετίζονται με την απόφαση, τον προγραμματισμό, την υλοποίηση και την αξιολόγηση του αποτελέσματος. Η αξιολόγηση αυτή μας επιτρέπει να εκτιμήσουμε την ορθή λειτουργία των συστημάτων ή την ανάγκη τροποποίησής τους. Προς αυτή την κατεύθυνση, σκοπός της παρούσας εργασίας είναι να παρουσιάσει τα κυριότερα χαρακτηριστικά της αξιολόγησης των εκπαιδευτικών οργανισμών και ιδρυμάτων ως υπόβαθρο μίας θεωρητικής προσέγγισης και ανάπτυξης της διαδικασίας της αξιολόγησης στο Ελληνικό Ανοικτό Πανεπιστήμιο, ώστε αφενός να γίνουν κατανοητές οι υπάρχουσες διαδικασίες μέσω των οποίων μέχρι σήμερα γίνεται η αξιολόγηση , αφετέρου να προκύψουν νέες πιο αποτελεσματικές. Τα ευρήματά της τονίζουν την ανάγκη για συστημική θεώρηση του εν λόγω ιδρύματος και ανανέωση των μηχανισμών αξιολόγησής του, αποτελώντας σημαντικά τεκμήρια της αναγκαιότητάς της για την αποτελεσματικότητα και βιωσιμότητα του ΕΑΠ.</p>
ΤΠΕ και εξ Αποστάσεως Εκπαίδευση στην υπηρεσία της Δια Βίου Μάθησης. Πρόσβαση στη γνώση ή ένας νέος ψηφιακός δυϊσμός;
Authors: ΣΑΧΙΝΙΔΗΣ Κ. , ΠΟΛΥΧΡΟΝΑΚΗΣ Γ. 
Published: June 2016

<p>Στην παρούσα εργασία, γίνεται μια προσπάθεια ανάδειξης των ΤΠΕ και της εξ αποστάσεως εκπαίδευσης (ΕξΑΕ) μέσω Διαδικτύου ως ένα σύγχρονο ελκυστικό εκπαιδευτικό εργαλείο, το οποίο μπορεί να συμβάλλει στη βελτίωση του αποτελέσματος μάθησης και διδασκαλίας στην υπηρεσία της Δια Βίου Μάθησης (ΔΒΜ), λειτουργώντας, τόσο συμπληρωματικά, όσο ακόμη και ως βασικό μέσο παροχής εκπαίδευσης και ένταξης των ενηλίκων στα νέα κοινωνικά και εργασιακά δεδομένα.</p><p>Στη εποχή μας, των συνεχών και γρήγορων μεταβολών στον κοινωνικοεργασιακό τομέα, η διαρκής ανανέωση και ο συνεχής εμπλουτισμός των γνώσεων και των δεξιοτήτων, αναδεικνύουν τη ΔΒΜ ως την απαραίτητη προϋπόθεση για την αρμονική και παραγωγική ένταξη των ενηλίκων στις «νέες εξελίξεις». Ένα σημαντικό μέσο πραγμάτωσης των σκοπών της ΔΒΜ μπορεί να αποτελέσει και η ΕξΑΕ με τη χρήση των ΤΠΕ, με στόχο την μετάβαση των εκπαιδευόμενων από την Κοινωνία της Πληροφορίας στην Κοινωνία της Γνώσης.</p><p>Όμως, παρά το γεγονός, ότι η ΔΒΜ αναγνωρίζεται, σε Ευρωπαϊκό επίπεδο καθώς και στην πατρίδα μας ως μια από τις σημαντικότερες ανάγκες-προτεραιότητες, στην πραγματικότητα η ΔΒΜ δεν έχει την θέση που της αρμόζει. Γιατί συμβαίνει κάτι τέτοιο; Ποιοι παράγοντες δυσχεραίνουν τη δυνατότητα των ευρύτερων πληθυσμιακών ομάδων για πρόσβαση στη γνώση μέσω της ΔΒΜ; Η εξ αποστάσεως εκπαίδευση με την χρήση των ΤΠΕ, μπορεί να προσφέρει τη δυνατότητα για πρόσβαση στη γνώση ή θα έχει σαν αποτέλεσμα την δημιουργία ενός νέου ψηφιακού δυϊσμού; Με ποιους τρόπους μπορεί να αποφευχθεί ο ψηφιακός δυϊσμός;­</p>
Μελέτη περίπτωσης για τη χρήση του L.M.S. Open E-Class για την υλοποίηση ηλεκτρονικών μαθημάτων από τμήματα του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών
Authors: ΣΟΦΟΣ Αλιβίζος , ΠΑΡΑΣΧΟΥ Βασίλειος 
Published: June 2016

<p><span style="font-family: Times New Roman; font-size: medium;">Η εργασία αποτελεί μια μελέτη περίπτωσης για τη χρήση του </span><span style="font-family: Times New Roman; font-size: medium;">learning</span><span style="font-family: Times New Roman; font-size: medium;">management</span><span style="font-family: Times New Roman; font-size: medium;">system</span><span style="font-family: Times New Roman; font-size: medium;">E</span><span style="font-family: Times New Roman; font-size: medium;">-</span><span style="font-family: Times New Roman; font-size: medium;">class</span><span style="font-family: Times New Roman; font-size: medium;">από τμήματα του Εθνικού Καποδιστριακού Πανεπιστημίου Αθηνών για την υλοποίηση ηλεκτρονικών μαθημάτων στην πλατφόρμα ασύγχρονης τηλε-εκπαίδευσης του φορέα «η-Τάξη». Για τους σκοπούς της μελέτης εξετάστηκαν 367 ηλεκτρονικά μαθήματα από 15 πανεπιστημιακά τμήματα με σκοπό να διερευνηθεί ο τρόπος υλοποίησης των μαθημάτων αυτών αλλά και του συστήματος διαχείρισης μάθησης από το Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών. Τα αποτελέσματα της μελέτης καταδεικνύουν την περιορισμένη χρήση των δυνατοτήτων του </span><span style="font-family: Times New Roman; font-size: medium;">E</span><span style="font-family: Times New Roman; font-size: medium;">-</span><span style="font-family: Times New Roman; font-size: medium;">Class</span><span style="font-family: Times New Roman; font-size: medium;"> για το σύνολο των υπό διερεύνηση ηλεκτρονικών μαθημάτων, σύμφωνα με το μοντέλο εμπλουτισμού (Siller, 2007), με συνέπεια τα τμήματα να επιτυγχάνουν χαμηλή βαθμολογία στη φόρμα αξιολόγησης που χρησιμοποιήθηκε για την καταγραφή και συγκέντρωση των στοιχείων.</span></p>
Συμπληρωματική εξ αποστάσεως εκπαίδευση στο Δημοτικό Σχολείο: Σχεδιασμός και Ανάπτυξη Πιλοτικού Έντυπου Εκπαιδευτικού Υλικού με την μέθοδο της εξαε με θέμα: «Βιώσιμη Ανάπτυξη και Ανανεώσιμες Πηγές Ενέργειας»
Authors: ΚΑΡΑΓΙΑΝΝΗ Δέσποινα , ΑΝΑΣΤΑΣΙΑΔΗΣ Παναγιώτης 
Published: June 2016

<p>Η συμπληρωματική εξ αποστάσεως εκπαίδευση αναδεικνύεται ως σημαντική παράμετρος στην εφαρμογή προγραμμάτων εξ αποστάσεως εκπαίδευσης στην πρωτοβάθμια και δευτεροβάθμια εκπαίδευση. Ο σχεδιασμός και η δημιουργία έντυπου εκπαιδευτικού υλικού με θέμα: «Βιώσιμη Ανάπτυξη και Ανανεώσιμες Πηγές Ενέργειας» αποτελεί το αντικείμενο ενασχόλησης αυτής της εργασίας. Το προτεινόμενο πιλοτικό εκπαιδευτικό υλικό σχεδιάστηκε για μαθητές των δύο τελευταίων τάξεων δημοτικού σχολείου και στοχεύει στην καλλιέργεια δεξιοτήτων ανάλυσης και κριτικής διερεύνησης περιβαλλοντικών προβλημάτων, στην καλλιέργεια θετικών στάσεων στο καινούριο και το εναλλακτικό και στην ενθάρρυνση του κριτικού στοχασμού με στόχο την κοινωνική συνειδητοποίηση, την πολιτισμική κριτική, την ανάληψη πρωτοβουλιών και δράσεων για το περιβάλλον.</p>