bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winimaku ara papa wiimatjaraku and other stories
Authors: Boko Margaret Nampitjinpa , Boko Rosalyn , Stefanoff Lisa 
Published: September 2024

AbstractThis audio‐visual essay invites readers to enter a new intermedial archive of documentary paintings and stories by a celebrated and prolific multilingual Central Australian Aboriginal woman artist. Addressing our written text to intimate family and audiences from elsewhere, in multiple voices and modes of address, we offer an opportunity to consider the dynamics of creating, keeping and caring for memory through the affordances of digital co‐creativity. These include what we term ‘painting remix animation’, a form of what co‐author Rosalyn Boko calls mixamilani (‘mixing together’ of different elements). Guided by the artist's vibrant palette and life‐expressive practice, visitors to the article can move and rest amongst a variety of standpoints through which to attune to questions of history, memory, pictorial storytelling, love, friendship and joy. We hope that in this way, everyone can sense the world‐making powers and poetics of colour and understand how our style of slow research towards digital mixamilani creates a new kind of archive for holding paintings carefully, outside of the art commodity market.
Cool burning the collection: Museum research as a regenerative act
Authors: Andrews Jilda 
Published: September 2024

AbstractEthnographic collections, as material repositories of historical relationships, are powerful bodies of intercultural knowledge and exchange. Indigenous people have been active and influential in the building of these collections and continue today to be critical to the ongoing interpretation and engagement of such repositories. When faced with the tangled, overgrowth of values accumulated around collected objects over time, regenerative processes can offer new life. By applying a metaphorical ‘cool burn’ it is hoped that space can be created where new shoots of knowledge can emerge. This research takes the form of a digital article twinned with an exegetical reflection to extend the notion of Indigenous engagement and so consider some of the regenerative potentials of collection research when Indigenous philosophies and concepts drive research enquiry and more importantly, frame outcomes.
Wik Cha'prah – Cha tru chath: Wik blood speaks to you
Authors: Oochunyung Fiona Wirrer‐George 
Published: September 2024

AbstractMy work to date explores and plays with bringing the essence of relational Arnya spirituality into new spaces and forms of conveyance, depiction and articulation. I do this by revisitation, re‐call and rearticulation of ancient songline eldership Voice teaching. Recall and retrieval from stored memory files articulates the knowledge narrative. The amalgamation of the organic internal filing system, the collective of kinship knowledge offerings ongoing and the digital produces transmutative narratives. Lived experience as inherited bloodline descendent further contextualises and embeds the spirit essence of voice. The body in which I dwell in, with all its parts in function, brings into being a new song vocabulary of Arnya through multi‐modal construction and conveyance. In this process, the collective of kinship in all its parts, organic and other, remain embedded in the emergence and continuity of voice and flow.
A bird, a flock, a song, and a forest: The decline of Regent Honeyeater life
Authors: van Dooren Thom , Sadokierski Zoë , Oakey Myles , Rissanen Timo , Widin Samuel , Crates Ross 
Published: September 2024

AbstractThe south‐eastern corner of the Australian continent was once crisscrossed by the nomadic flight paths of the Regent Honeyeater. For hundreds of thousands of years, they winged their way up and down this vast continent. Today, however, the species is listed as critically endangered and is just clinging to existence. This multimedia essay tells the story of this decline, exploring the complex, co‐shaping, relationships between individual birds and their flocks, their songs, and their forests. While these are relationships that might be glossed as being social, cultural, and ecological (respectively), and so belonging to separate domains of life, they are in reality delicately interwoven elements of what it is to be a Regent Honeyeater; relationships that, taken together, have been integral to the emergence and ongoing life of this species. In attending to the breakdown of these relationships in our present time, this essay seeks to develop new resources for storying loss in a time of ongoing extinctions. Bringing text into conversation with images and audio, the essay works to draw the reader/viewer/listener into an encounter with an unravelling world. Ultimately, our aim has been to create an essay in which the conceptual ideas, the design, and the biology of the species described, are brought into some sort of alignment that allows them to become mutually reinforcing elements of a storied encounter. Our reflection on the process of creating this essay are provided in the accompanying exegetical commentary.
How to … do decolonial research
Authors: Sims Danica Anne , Naidu Thirusha 
Published: September 2024

AbstractThe imperative for decolonial research in health professions education (HPE) is rooted in a resistance to coloniality, which characterises modern medicine and HPE. Coloniality is a residual effect of colonialism, which upholds White, Western, Eurocentric knowledge systems while simultaneously marginalising diverse epistemologies. We outline the problematic nature of coloniality in HPE typified in unequal research partnerships, skewed student exchanges and poor representation of diverse authors. Decoloniality advocates for the active disruption and dismantling of colonial hierarchies to promote epistemic justice. We suggest a practical framework for applying decolonial principles in research, emphasising awareness (critical consciousness), deliberation (reflexivity) and action (transformative praxis). Practical steps for decolonial practice include interrogating research conceptualisation, sharing power and diversifying research teams, adopting participatory and reciprocal (mutually beneficial) methodologies, (re)centring marginalised voices and amplifying ‘Other’ knowledges, and disrupting hegemonic dissemination practices. By employing decolonial strategies, researchers can produce equitable, socially accountable and epistemically just scholarship, ultimately enhancing the relevance and impact of HPE research for all people globally.
Prawitz's completeness conjecture: A reassessment
Authors: Schroeder‐Heister Peter 
Published: September 2024

AbstractIn 1973, Dag Prawitz conjectured that the calculus of intuitionistic logic is complete with respect to his notion of validity of arguments. On the background of the recent disproof of this conjecture by Piecha, de Campos Sanz and Schroeder‐Heister, we discuss possible strategies of saving Prawitz's intentions. We argue that Prawitz's original semantics, which is based on the principal frame of all atomic systems, should be replaced with a general semantics, which also takes into account restricted frames of atomic systems. We discard the option of not considering extensions of atomic systems, but acknowledge the need to incorporate definitional atomic bases in the semantic framework. It turns out that ideas and results by Westerståhl on the Carnap categoricity of intuitionistic logic can be applied to Prawitz semantics. This implies that Prawitz semantics has a status of its own as a genuine, though incomplete, semantics of intuitionstic logic. An interesting side result is the fact that every formula satisfiable in general semantics is satisfiable in an axioms‐only frame (a frame whose atomic systems do not contain proper rules). We draw a parallel between this seemingly paradoxical result and Skolem's paradox in first‐order model theory.
Validity of inferences and validity of demonstrations
Authors: Sundholm Göran 
Published: September 2024

AbstractThe lecture spells out the difference between the validity of inference (‐figure)s and validity applied to demonstrations (‘proof acts’). The latter notion is not an ordinary characterizing one; in Brentano's terminology it is a modifying one. A demonstration lacking validity is not a real demonstration, just as a false friend is no true friend. Throughout, the treatment makes crucial use of an epistemological perspective that is cast in the first person. Furthermore, the difference between (logical) consequence among propositions and the validity of inference from judgement to judgement is explained. Particular attention is paid to alleged issues of circularity in the definition of the validity of inference, and to the ‘explosion’ validity of inference from contradictory premisses. Drawing upon a version of the dialogical framework of Per Martin‐Löf, namely, ‘When I say Therefore, I give others my permission to assert the conclusion’, while stressing also the importance of the first person perspective, both difficulties can be neutralized.
Do tax incentives for innovation attract high‐technology investment from emerging markets? Evidence from China's outward foreign direct investment
Authors: Ma Shuzhong , Liu Kai , Wu Peng 
Published: September 2024

AbstractWe examine whether the innovation box regime (IBR), a tax incentive with lower tax rates on intellectual property (IP)‐related income, attracts high‐technology investment from emerging markets. Using the staggered difference‐in‐differences (DID) method, we find that China's high‐technology investment in IBR countries, relative to non‐IBR countries, increases significantly after the implementation of IBR. This finding is robust to a battery of sensitivity tests. The mechanism analysis suggests that the attraction of the IBR for high‐technology investment is realised through the encouragement of innovation, and this finding is also verified in the heterogeneity analysis. We also find that the IBR has a positive effect on high‐technology investment only if the tax incentives apply to pre‐existing IP before the regime implementation, and the ease with which enterprises can directly use the latest technologies in the host country does not have an impact on the effectiveness of the IBR. Moreover, the effect of IBR on M&A is larger than that on greenfield investment. Our study contributes to the literature and policy assessment on IBR.
On a Galois property of fields generated by the torsion of an abelian variety
Authors: Checcoli S. , Dill G. A. 
Published: September 2024

AbstractIn this article, we study a certain Galois property of subextensions of , the minimal field of definition of all torsion points of an abelian variety defined over a number field . Concretely, we show that each subfield of that is Galois over (of possibly infinite degree) and whose Galois group has finite exponent is contained in an abelian extension of some finite extension of . As an immediate corollary of this result and a theorem of Bombieri and Zannier, we deduce that each such field has the Northcott property, that is, does not contain any infinite set of algebraic numbers of bounded height.
DATA DRIVEN AND CELL SPECIFIC DETERMINATION OF NUCLEI-ASSOCIATED ACTIN STRUCTURE
Authors: Nikitina N.N , Bursa N. , Satici A. , Uzer G. 
Published: September 2024

In the specialized field of cellular mechanosignaling, the intricate relationship between the cytoskeleton and nucleus is crucial for determining the behavior and fate of mesenchymal stem cells (MSCs). Existing analytical methods for filamentous actin fibers (F-actin) suffer from issues of accuracy and reproducibility. To address this, our research introduces a significant advancement in image analysis by utilizing two deep-learning segmentation Convolutional Neural Networks (CNNs) based on U-Net architecture. This algorithm precisely quantifies F-actin and offers reproducible data from 3D confocal microscopy images. Our CNNs automatically extract the 3D shape of both the nucleus and individual actin fibers, thereby enabling the geometric reconstruction of these critical cellular components. We applied this methodology to MSCs exposed to low-intensity vibration, and hypothesized that mechanical stimuli will induce perinuclear actin remodeling.
Confocal Z-stack images of MSCs were captured using a 40x oil lens and a Zeiss LSM 900 microscope. Nucleus and F-actin structures were stained with Hoechst 33342 and Phalloidin, respectively. Nucleus-based images were employed to mask and isolate actin fibers within the nuclear vicinity.
A specialized deep-learning segmentation model was engineered within the PyTorch framework. For model training, a selective 2% of nuclei and F-actin images were annotated. Specifically, three layers from each of six representative nuclei, among approximately 500 cross-sectional layers, were meticulously selected; a similar approach was employed for actin. The model underwent 200 epochs of training. Post-training, the deep-learning model was employed to process all collected cross-sectional images of F-actin and nuclei. A subsequent analytical step involved the scrutiny of intersecting segmented fibers between consecutive layers for geometrically accurate actin fiber reconstruction.
We analyzed 102 control and 110 vibration-treated mesenchymal stem cells (MSCs) by utilizing our deep-learning-based reconstruction algorithm on confocal Z-stack images. Our data revealed an 8% decrease in nuclear height from 5.73 µm to 5.28 µm (p < 0.001) upon application of low-intensity vibration. In contrast, the two groups observed no significant difference in nuclear volume. Accompanying these changes at the nuclear level, the following changes in the F-actin cytoskeleton were observed upon LIV application. The total number of actin filaments per cell increased from 117 to 150. The average volume of individual actin fibers rose from 0.40 µm³ to 0.43 µm³. Notably, the volume of fibers at the apical nuclear surface increased from 0.35 µm³ to 0.46 µm³.
While the average length of actin fibers in the apical nuclear surface remained largely unchanged due to the addition of smaller fibers in LIV groups, the LIV group had a larger number of fibers that were larger than 15µm.
АНАЛИЗ ИНДУЦИРОВАНИЯ АНТИТЕЛ С ИСПОЛЬЗОВАНИЕМ МЫШИНЫХ МАКРОФАГОВ, ОБРАБОТАННЫХ EX VIVO РЕКОМБИНАНТНЫМИ ЧЕЛОВЕЧЕСКИМИ БЕЛКАМИ
Authors: Нуртлеу М. 
Published: September 2024

Макрофаги представляют собой важный клеточный компонент, содержащийся в различных тканях организма. Они модулируют имунный ответ против патогенов, поддерживая гомеостаз тканей в организме. Особый интерес в изучении макрофагов связан с их прогностической способностью к индуцированию противоракового иммунитета и осуществлнеию фагоцитоза раковых клеток. Это определяет важность ex vivo обработки макрофагов рекомбинантными человеческими белками PD-L1 (rPD-L1), CTLA-4 (rCTLA-4) и PD-1 (rPD-1) для создания персонализированного иммунитета против цитотоксического лимфоцита 4 типа (CTLA-4), лиганда рецептора программируемой клеточной гибели 1 (PD-L1) и белка запрограммированной клеточной смерти 1 (PD-1).
Исследование развития гуморального иммунитета против CTLA-4, PD-L1 и PD-1 проводилось посредством введения мышам макрофагов, обработанных ex vivo соответствующими белками. Для иммунизации и получения макрофагов использовались инбредные самки мышей линии BALB в возрасте 6–8 недель. Положительную сыворотку получали путем внутрибрюшинного введения рекомбинантных белков. Наличие антител детектировали с использованием иммуноферментного анализа (ИФА). Результаты оценивали с использованием статистической обработки. Перитонеальные макрофаги мышей BALB/c культивировались в среде, содержащей рекомбинантные человеческие белки CTLA-4, PD-L1 и PD-1. Макрофаги, обработанные рекомбинантными белками анализировали посредством иммунофлуоресцентного окрашивания с использованием антител против CTLA-4, PD-L1 и PD-1. Обработанные макрофаги вводили мышам внутрибрюшинно для индукции антител против CTLA-4, анти-PD-L1 и анти-PD-1. Титр антител у вакцинированных мышей определяли методом иммуноферментного анализа с последующей статистической обработкой результатов. Специфичность антител определяли иммунофлуоресцентным окрашиванием клеток MCF7.
Способность макрофагов активировать клеточный и гуморальный иммунитет стала основой их использования в терапии онкологических и инфекционных заболеваний. Успех лечения макрофагами связан с их способностью активировать иммунитет независимо от условий загрузки клеток антигенами. Макрофаги, загруженные ex vivo rCTLA-4, rPD-L1 и rPD-1, индуцировали достаточно высокие титры антител у вакцинированных мышей. Кроме того, иммунофлуоресцентное окрашивание показало, что антитела против rCTLA-4 и rPD-L1 специфически реагируют с клетками MCF7. Дальнейшие исследования макрофагов и ДК, презентирующих rCTLA-4, rPD-L1 и rPD-1, могут привести к новым подходам в иммунизации против онкологических и инфекционных заболеваний. Обработка макрофагов ex vivo rCTLA-4, rPD-L1 и rPD-1 может помочь индуцировать гуморальный иммунитет и разработать инновационные методы в иммунотерапии рака.
Hip Fracture in the Sportive Adult: Case Report of Complete Functional Recovery After Removal of Hardware
Authors: Lormans Pieter , Loos Pieter-Jan , Vanbrabant Stefanie , Quetin Philippe , Huybrechts Xavier , Ghekiere Olivier 
Published: September 2024

Context: Pertrochanteric hip fractures in sportive young adults are mainly caused by a high-energy trauma and treated in the same way as in the older population, using an osteosynthesis immediately followed by a rehabilitation program for several months. The current standard is not to remove osteosynthesis material, similar to the case of older patients. Case Presentation: A 45-year-old male cyclist experienced a right pertrochanteric femoral fracture, treated with cephalomedullary nails. After 9 months of adequate rehabilitation, weakness of the quadriceps musculature and functional complaints persisted, objectified through an isokinetic strength test and a significantly reduced score on the Hip Disability and Osteoarthritis Outcome Score questionnaire. The patient was unable to return to his previous level of cycling performance. Management and Outcome: After exclusion of structural bone complications, nerve injury, and central sensitization, the functional complaints and strength deficiency were hypothesized to be related to the osteosynthesis material. Therefore, the hardware was removed 9 months after the first surgery, and the rehabilitation was continued for another 20 weeks. Very soon after the removal of the hardware, the functional complaints disappeared with a remarkable improvement of the Hip Disability and Osteoarthritis Outcome Score. The isokinetic strength test showed complete recovery of muscle strength 20 weeks after osteosynthesis removal, and preinjury cycling performance values were obtained 9 months posthardware removal. Conclusion: Despite an adequate rehabilitation following a hip fracture, sporty young adults may fail to reach their previous level of functioning. Osteosynthesis removal may be indicated in this sportive population to reach complete muscle strength and functional recovery. The management of hip fractures in the sportive young adult and the identification of patients who may benefit from removal of the hardware require more research.
Reduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection by blocking the epidermal growth factor receptor (EGFR) pathway
Authors: Han Yeonju , Kim Seunghwan , Park Taehyun , Hwang Hyemin , Park Sanghee , Kim Jimin , Pyun Jae-chul , Lee Misu 
Published: September 2024

ABSTRACT

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants presents challenges in global efforts to transition from the pandemic to an endemic stage. The spike protein of the SARS-CoV-2 virus, which is pivotal for cell entry, exhibits significant mutations in its variants, potentially affecting infectivity and therapeutic efficacy. Recent findings indicate upregulation of the epidermal growth factor receptor (EGFR) pathway, a key target in cancer therapy, by the spike protein of SARS-CoV-2. This study aimed to investigate the activity of the EGFR pathway against SARS-CoV-2 variants and to assess the inhibitory effects of EGFR inhibitors using SARS-CoV variant pseudoviral particles to guide future therapeutic strategies. Omicron variant SARS-CoV pseudoviral particles exhibited heightened infectivity in human angiotensin-converting enzyme 2 (hACE2)-expressing HEK293 and A549 lung cancer cells accompanied by increased EGFR pathway activation in infected cells. Using the EGFR tyrosine kinase inhibitor, osimertinib, we observed a reduction in viral infection rates in hACE2-HEK293 and A549 cells infected with the SARS-CoV-2 variant pseudoviral particles. We conducted further experiments to confirm that the reduction in infection efficacy with osimertinib treatment was not associated to a decrease in cell viability. Furthermore, this inhibitory effect of osimertinib in cell lines was corroborated in a spheroid cell culture model derived from hACE2-A549 cells. These findings suggest the potential application of EGFR-targeted antiviral therapy against highly infectious SARS-CoV-2 variants.

IMPORTANCE
The emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is concerning as vaccines designed for one variant need not essentially protect against other novel variants. Therefore, there is an urgent need to identify therapies that can act against multiple novel variants that have heightened virulence compared with the wild type. It has been reported that the spike protein of the SARS-CoV-2 virus elicits an increased expression of the epidermal growth factor receptor (EGFR) pathway. We used this information and examined whether treatment with an EGFR inhibitor, osimertinib, which is already approved for clinical use in cancer therapy, can reduce the infection caused by SARS-CoV-2, wild type, and Omicron and Delta variants, in two cell lines and one spheroid model. The results showed that osimertinib treatment successfully reduced infection efficacy, particularly in variants, and that this effect was not related to a reduction in cell viability, making this a promising strategy for treating SARS-CoV-2 infections.
Virtual clinical simulation as a paedagogical strategy in healthcare learning: Evidence and Gap Map protocol
Authors: Engler Jamille Costa , Castro Luiza Sheyla Evenni Porfírio Will , Guesser Joice Cristina , da Silva Flôr Janaína , De Luca Canto Graziela , Zimmermann Glaucia Santos , Lino Monica Motta 
Published: September 2024

IntroductionVirtual clinical simulation involves creating and applying scenarios using technology like computers or virtual reality. This method provides a secure experiential learning environment, encouraging active student participation and stimulating clinical, critical and reflective thinking. This article outlines the development of the Evidence and Gap Map, which aims to identify, quantify and visually and interactively classify existing systematic reviews on the effectiveness of virtual clinical simulations in health professional training.Methods and analysisThe Evidence and Gap Map will adhere to the Campbell Collaboration Guidelines. Bibliographic searches in six databases will follow inclusion criteria determined by the Population, Intervention, Comparison, Outcome and Study design strategy. After the initial calibration, two reviewers will independently apply the inclusion and exclusion criteria to the title and abstract of each identified study, with subsequent full reading of the selected articles. The methodological quality of the included systematic reviews will be assessed with the AMSTAR 2 tool. The map will be developed using the EPPI-Mapper software.Ethics and disseminationThere is no requirement for ethical approval for this systematic review. On completion, it will be published in a peer-reviewed academic journal and presented at a conference. This review protocol was registered on the Open Science Framework platform (OSF Associated Project Registration: osf.io/r6wdc and received the following DOI: 10.17605/OSF.IO/R6WDC).