bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy, cognition, and urinary incontinence among geriatric inpatients discharged to skilled nursing facilities
Authors: Cohn Joshua A. , Shah Avantika S. , Goggins Kathryn M. , Simmons Sandra F. , Kripalani Sunil , Dmochowski Roger R. , Schnelle John F. , Reynolds William Stuart 
Published: August 2017

AimsTo investigate the association between health literacy and cognition and nursing and patient‐reported incontinence in a geriatric inpatient population transitioning to skilled nursing facilities (SNF).MethodsHealth literacy, depression, and cognition were assessed via the Brief Health Literacy Screen (BHLS), Geriatric Depression Scale 5‐item (GDS) and Brief Interview for Mental Status (BIMS), respectively. Multivariable logistic regression assessed the association between BHLS score and incontinence by: (1) nursing‐reported urinary incontinence during hospitalization; and (2) patient self‐reported “bladder accidents” in the post‐enrollment study interview.ResultsA total of 1556 hospitalized patients aged 65 and older met inclusion criteria, of whom 922 (59.3%) were women and 1480 had available BHLS scores. A total of 464 (29.8%) and 515 (33.1%) patients had nursing‐reported and self‐reported urinary incontinence, respectively. Nursing‐reported incontinence was significantly associated with lower BHLS (ie, poorer health literacy) (aOR 0.93, 95%CI 0.89‐0.99) and BIMS (ie, poorer cognition) (aOR 0.90, 95%CI 0.83‐0.97) scores and need for assistance with toileting (aOR 7.08, 95%CI 2.16‐23.21). Patient‐reported incontinence was significantly associated with female sex (aOR 1.62, 95%CI 1.19‐2.21), increased GDS score (ie, greater likelihood of depression) (aOR 1.22, 95%CI 1.10‐1.36) and need for assistance with toileting (aOR 2.46, 95%CI 1.26‐4.79).ConclusionsPoorer health literacy and cognition are independently associated with an increased likelihood of nursing‐reported urinary incontinence among geriatric inpatients transitioning to SNF. Practitioners should consider assessment of health literacy and cognition in frail patients at risk for urinary incontinence and that patient and nursing assessment may be required to capture the diagnosis.
Enabling autonomicity in wireless mesh networks with the ETSI AFI GANA reference model
Authors: Szott Szymon , Gozdecki Janusz , Kosek‐Szott Katarzyna , Loziak Krzysztof , Natkaniec Marek , Wagrowski Michal , Chaparadza Ranganai 
Published: August 2017

SummaryThe distributed nature of wireless mesh networks (WMNs) allows them to benefit from multiple autonomic functionalities. However, the existing landscape of self‐x solutions (eg, self‐configuration) is fragmented and the lack of a standardized framework through which interoperable autonomics can be developed has been hampering adoption and deployment of autonomics in real‐world service networks. There is a need for a standardized architectural framework that enables to comprehensively support and integrate interoperable components for autonomicity in WMNs. Such an architecture (autonomicity‐enabled wireless mesh architecture) is currently being standardized by the working group called Evolution of Management towards Autonomic Future Internet (AFI) in the European Telecommunications Standards Institute within the Network Technologies Technical Committee. The proposed autonomic wireless mesh architecture is an instantiation of the AFI GANA (Generic Autonomic Network Architecture) reference model, a standards‐based approach to autonomics. This paper complements and extends the early version of the architecture by further detailing the architectural principles and providing experimental and validation results. First, we provide a brief overview of the AFI GANA reference model and then show how each of its building blocks can be instantiated for WMNs. We evaluate the proposed architecture by implementing and testing the 4 basic self‐x functionalities defined by the GANA model. The provided guidelines can now help researchers and engineers build autonomicity‐enabled WMNs using a standardized framework that enables adoption and deployment of autonomics by industry, thereby enabling researchers and engineers to contribute to the further evolution of the standard in the European Telecommunications Standards Institute.
Clinician provision of oncofertility support in cancer patients of a reproductive age: A systematic review
Authors: Logan S. , Perz J. , Ussher J. , Peate M. , Anazodo A. 
Published: August 2017

AbstractObjectiveThe emerging discipline of oncofertility advocates for the timely provision of fertility information and referral for fertility preservation to all cancer patients of reproductive age (<45 years). A systematic review was undertaken on the clinician provision of oncofertility support to determine whether cancer patients are having their support needs adequately met by staff.MethodsAn initial search conducted in May 2016 identified 351 potentially relevant studies. The papers were divided into 2 categories: Papers on the clinician provision of oncofertility support were reviewed for this study, and papers on patient oncofertility support needs were reviewed for a separate systematic review.ResultsA total of 23 studies were included within the final review of this manuscript. Although many clinicians are broadly informed about the risk to their patients' fertility brought about by cancer treatment, there are many factors which hinder the appropriate discussion, referral, or service utilisation needed to provide adequate oncofertility support to patients of reproductive age.ConclusionsOncofertility support is often not delivered to the standard of current guidelines, with many clinicians not providing the recommended care to all eligible patients, and as such many patients may lack the oncofertility support that they require. The implementation of a clear procedural process would assist clinicians in the provision of oncofertility support for cancer patients of reproductive age.
Ensemblator v3: Robust atom‐level comparative analyses and classification of protein structure ensembles
Authors: Brereton Andrew E. , Karplus P. Andrew 
Published: August 2017

AbstractEnsembles of protein structures are increasingly used to represent the conformational variation of a protein as determined by experiment and/or by molecular simulations, as well as uncertainties that may be associated with structure determinations or predictions. Making the best use of such information requires the ability to quantitatively compare entire ensembles. For this reason, we recently introduced the Ensemblator (Clark et al., Protein Sci 2015; 24:1528), a novel approach to compare user‐defined groups of models, in residue level detail. Here we describe Ensemblator v3, an open‐source program that employs the same basic ensemble comparison strategy but includes major advances that make it more robust, powerful, and user‐friendly. Ensemblator v3 carries out multiple sequence alignments to facilitate the generation of ensembles from non‐identical input structures, automatically optimizes the key global overlay parameter, optionally performs “ensemble clustering” to classify the models into subgroups, and calculates a novel “discrimination index” that quantifies similarities and differences, at residue or atom level, between each pair of subgroups. The clustering and automatic options mean that no pre‐knowledge about an ensemble is required for its analysis. After describing the novel features of Ensemblator v3, we demonstrate its utility using three case studies that illustrate the ease with which complex analyses are accomplished, and the kinds of insights derived from clustering into subgroups and from the detailed information that locates significant differences. The Ensemblator v3 enhances the structural biology toolbox by greatly expanding the kinds of problems to which this ensemble comparison strategy can be applied.
A comparison of operative outcomes between standard and robotic laparoscopic surgery for endometrial cancer: A systematic review and meta‐analysis
Authors: Ind Thomas , Laios Alex , Hacking Matthew , Nobbenhuis Marielle 
Published: August 2017

AbstractBackgroundEvidence has been systematically assessed comparing robotic with standard laparoscopy for treatment of endometrial cancer.MethodsA search of Medline, Embase and Cochrane databases was performed until 30th October 2016.ResultsThirty‐six papers including 33 retrospective studies, two matched case–control studies and one randomized controlled study were used in a meta‐analysis. Information from a further seven registry/database studies were assessed descriptively. There were no differences in the duration of surgery but days stay in hospital were shorter in the robotic arm (0.46 days, 95%CI 0.26 to 0.66). A robotic approach had less blood loss (57.74 mL, 95%CI 38.29 to 77.20), less conversions to laparotomy (RR = 0.41, 95%CI 0.29 to 0.59), and less overall complications (RR = 0.82, 95%CI 0.72 to 0.93). A robotic approach had higher costs ($1746.20, 95%CI $63.37 to $3429.03).ConclusionA robotic approach has favourable clinical outcomes but is more expensive.
Poorer without It? The Neglected Role of the Natural Environment in Poverty and Wellbeing
Authors: Schleicher Judith , Schaafsma Marije , Burgess Neil D. , Sandbrook Chris , Danks Fiona , Cowie Chris , Vira Bhaskar 
Published: August 2017

AbstractThe relationship between sustainable development's prime goal, human wellbeing, and the natural environment has been narrowly conceived. This paper focuses on the possibility and the implications of treating the natural environment as a ‘constituent’, or internal element, of the concepts of wellbeing and poverty, as opposed to a ‘determinant’, or instrumental, external factor. Our review of philosophical accounts and conceptual frameworks of wellbeing and poverty suggests that treating the environment as a constituent element is philosophically sound, conceptually robust and empirically grounded. We argue that failing to consider these missing environmental aspects can result in an incomplete capturing of the multiple dimensions of wellbeing and poverty, and their underlying drivers. This broader framing of the environment–wellbeing relationship has the potential to inform a new generation of individual level wellbeing and poverty indicators, creating measures of multidimensional poverty that reflect the broadened scope ambitiously articulated in the Sustainable Development Goals. Copyright © 2017 The Authors. Sustainable Development published by ERP Environment and John Wiley & Sons Ltd
Growth and characterization of ultrathin carbon films on electrodeposited Cu and Ni
Authors: Pedrazzetti L. , Nobili L. , Magagnin L. , Bernasconi R. , Lucotti A. , Soltani P. , Mezzi A. , Kaciulis S. 
Published: August 2017

AbstractUltrathin carbon films were grown on different types of metallic substrates. Free‐standing foils of Cu and Ni were prepared by electroforming, and a pure Ni film was obtained by galvanic displacement on a Si wafer. Commercial foil of Ni 99.95% was used as a reference substrate. Carbon films were grown on these substrates by chemical vapour deposition in a CH4‐H2 atmosphere. Obtained films were characterized by Raman spectroscopy, X‐ray photoelectron spectroscopy (XPS), Auger electron spectroscopy, and ultraviolet photoemission spectroscopy. The XPS at grazing collection angle was used to determine the thickness of carbon films.Depending on the deposition parameters, the films of graphene or graphite were obtained on the different substrates. The uniformity of graphene and its distribution over the sample area were investigated from Raman data, optical images, and XPS chemical maps. The presence of graphene or graphite in the films was determined from the Raman spectra and Auger peak of C KVV. For this purpose, the D parameter, which is a fingerprint of carbon allotropes, was determined from C KVV spectra acquired by using X‐rays and electron beam. A formation of an intermediate layer of metal hydroxide was revealed in the samples with graphene overlayer.
Cr–Containing Magnetic Oxides in a Methanol Synthesis: Does Cr Ion Distribution Matter?
Authors: Baird Nicholas , Dittmar Jasper W. , Losovyj Yaroslav B. , Pink Maren , Morgan David Gene , Stein Barry D. , Torozova Alexandra S. , Krasnova Irina Yu. , Grigoriev Maxim E. , Sidorov Alexander I. , Sulman Mikhail G. , Shifrina Zinaida B. , Bronstein Lyudmila M. 
Published: August 2017

AbstractHere, we report on the development of novel Cr‐containing magnetic oxide nanoparticles (NPs) as catalysts for a syngas‐to‐methanol reaction which constitutes a sustainable route to obtain value‐added chemicals. These NPs have been synthesized in a one‐pot reaction by thermal decomposition of Cr acetylacetonate and doping metal acetylacetonates (if used) in the reaction solution of preformed magnetite NPs stabilized by polyphenylquinoxaline. For all the samples, the NP surface is enriched with Cr. At the same time, the Cr species are finely dispersed in the magnetite phase. This exposes Cr catalytic species to reacting molecules and creates an intimate contact between Cr3+ and Fe3O4. As a result, the methanol productivity rate for the Cr‐containing magnetic oxide prepared with 0.5 mmol of the Cr precursor is approximately three orders of magnitude higher than that for the conventional Cu/ZnO/Al2O3 catalyst. Additional doping of this Cr‐containing magnetic oxide with small amounts of Ni or La leads to even higher catalytic activity (by 40–49%).
Synthesis of 4‐Formyl‐2‐arylbenzofuran Derivatives by PdCl(C3H5)dppb‐Catalyzed Tandem Sonogashira Coupling‐Cyclization under Microwave Irradiation ‐ Application to the Synthesis of Viniferifuran Analogues
Authors: Vo Duy D. , Elofsson Mikael 
Published: August 2017

AbstractHerein we present the use of low catalyst loading of PdCl(C3H5)dppb (1 mol%) to directly prepare 4‐CHO‐2‐arylbenzofurans by copper‐free tandem Sonogashira coupling‐cyclization under microwave irradiation. The method was utilized to prepare highly substituted analogues of viniferifuran, a biologically active resveratrol dimer. Key transformations included the application of PdCl(C3H5)dppb (5 mol%) catalyzed direct arylation of C‐3 sterically congested C‐2 and C‐4 substituted benzofuran substrates. Finally, we demonstrated that BCl3/TBAI is superior to BBr3 for final demethylation.
GA-Binding Protein Alpha Is Involved in the Survival of Mouse Embryonic Stem Cells
Authors: Ueda Atsushi , Akagi Tadayuki , Yokota Takashi 
Published: August 2017

Abstract
Ets-related transcription factor GA-binding protein alpha (GABPα), which is encoded by Gabpa, is expressed in a variety of cell types and is involved in cellular functions such as cell cycle regulation, apoptosis, and differentiation. Here, we generated Gabpa conditional knockout embryonic stem cells (ESCs) and characterized its cellular phenotypes. Disruption of Gabpa revealed that the proliferation of Gabpa-null ESCs was drastically repressed and cells started to die within 2 days. The repressed proliferation of Gabpa-null ESCs was recovered by artificially forced expression of GABPα. Expression analysis showed that p53 mRNA levels were comparable; however, p53 target genes, including Cdkn1a/p21, Mdm2, and Gadd45a, were upregulated and cell cycle-related genes, including Cyclin D1/D2 and Cyclin E1/E2, were downregulated in Gabpa-null ESCs. Interestingly, p53 and cleaved Caspase3 expressions were enhanced in the cells and reduced proliferation as well as cell death of Gabpa-null ESCs were rescued by either transfection of p53 RNAi or treatment of the p53 inhibitor pifithrin-α. These results suggest that GABPα inhibits the accumulation of p53 and is involved in the proliferation and survival of ESCs.
Transarterial chemoembolization with miriplatin vs. epirubicin for unresectable hepatocellular carcinoma: a phase III randomized trial
Authors: Ikeda Masafumi , Kudo Masatoshi , Aikata Hiroshi , Nagamatsu Hiroaki , Ishii Hiroshi , Yokosuka Osamu , Torimura Takuji , Morimoto Manabu , Ikeda Kenji , Kumada Hiromitsu , Sato Tosiya , Kawai Ikuko , Yamashita Toru , Horio Hiroshi , Okusaka Takuji ,   Miriplatin TACE Study Group
Published: August 2017

Abstract
Background
This prospective study investigated the superiority of transarterial chemoembolization (TACE) with miriplatin over TACE with epirubicin regarding overall survival (OS) in patients with unresectable hepatocellular carcinoma (HCC).

Methods
Patients with unresectable HCC were randomized 1:1 to receive TACE with miriplatin or epirubicin in lipiodol. The primary endpoint was OS; secondary endpoints were percentages of patients who achieved treatment effect (TE) 4 (100% necrotizing effect or tumor reduction), duration of time to TACE failure, and adverse events (AEs). OS was compared using a stratified log-rank test adjusted for clinical stage, Child–Pugh class, and institution.

Results
Of 257 patients enrolled from August 2008 to August 2010, 247 were analyzed for efficacy and toxicity (miriplatin, n = 124; epirubicin, n = 123). Baseline characteristics were well balanced between the two groups. Median OS times were 1111 days for miriplatin and 1127 days for epirubicin (adjusted hazard ratio 1.01, 95% confidence interval 0.73–1.40, P = 0.946). TE4 rates were 44.4% for miriplatin and 37.4% for epirubicin. Median times to TACE failure were 365.5 days for miriplatin and 414.0 days for epirubicin. AEs of grade 3 or higher, including elevated aspartate aminotransferase (miriplatin, 39.5%; epirubicin, 57.7%) and elevated alanine aminotransferase (miriplatin, 31.5%; epirubicin, 53.7%), were less frequent in the miriplatin than the epirubicin group.

Conclusions
OS after TACE with miriplatin was not superior to that after TACE with epirubicin; however, hepatic AEs were less frequent with miriplatin.
Clinical Trial Registration: JapicCTI-080632.
The influence of invasive mongoose on the genetic structure of the endangered Amami rabbit populations
Authors: Ohnishi Naoki , Kobayashi Soh , Nagata Junco , Yamada Fumio 
Published: August 2017

AbstractInvasive carnivores often cause heavy damage to native species on small islands. Endangered Amami rabbit (Pentalagus furnessi) populations have been fragmented into a north‐isolated population (NI) and a south‐large population (SL) caused by predation pressure from the invasive small Indian mongoose (Herpestes auropunctatus) on Amami Oshima Island in southern Japan. We investigated the genetic structure of these rabbit populations to determine the effects of fragmentation. We collected rabbit feces from most of the Amami Oshima Island habitat and sequenced the mitochondrial DNA (mtDNA) control region along with its 5′‐flanking region (312 bp) and genotyped eight microsatellite DNA loci. Genetic diversity was lower in the NI than that in the SL population, andFSTvalues between the two populations were significantly higher than zero in both the mtDNA and microsatellite DNA. Bayesian clustering analyses suggested four ancestral clusters of Amami rabbit, but clear genetic structure was not observed. A partial Mantel test supported isolation‐by‐distance but not habitat fragmentation. These results suggest that the low genetic diversity in the NI population was caused by the small population size after fragmentation; however, the difference in genetic structure between the two populations was caused by isolation‐by‐distance and the structure has been maintained.
Increasing Inequality in Parent Incomes and Children’s Schooling
Authors: Duncan Greg J. , Kalil Ariel , Ziol-Guest Kathleen M. 
Published: August 2017

AbstractIncome inequality and the achievement test score gap between high- and low-income children increased dramatically in the United States beginning in the 1970s. This article investigates the demographic (family income, mother’s education, family size, two-parent family structure, and age of mother at birth) underpinnings of the growing income-based gap in schooling using data from the Panel Study of Income Dynamics. Across 31 cohorts, we find that increases in the income gap between high- and low-income children account for approximately three-quarters of the increasing gap in completed schooling, one-half of the gap in college attendance, and one-fifth of the gap in college graduation. We find no consistent evidence of increases in the estimated associations between parental income and children’s completed schooling. Increasing gaps in the two-parent family structures of high- and low-income families accounted for relatively little of the schooling gap because our estimates of the (regression-adjusted) associations between family structure and schooling were surprisingly small for much of our accounting period. On the other hand, increasing gaps in mother’s age at the time of birth accounts for a substantial portion of the increasing schooling gap: mother’s age is consistently predictive of children’s completed schooling, and the maternal age gap for children born into low- and high-income families increased considerably over the period.
Anatomic Sites and Associated Clinical Factors for Deep Dyspareunia
Authors: Yong Paul J. , Williams Christina , Yosef Ali , Wong Fontayne , Bedaiwy Mohamed A. , Lisonkova Sarka , Allaire Catherine 
Published: August 2017

Abstract

Introduction
Deep dyspareunia negatively affects women’s sexual function. There is a known association between deep dyspareunia and endometriosis of the cul-de-sac or uterosacral ligaments in reproductive-age women; however, other factors are less clear in this population.

Aim
To identify anatomic sites and associated clinical factors for deep dyspareunia in reproductive-age women at a referral center.

Methods
This study involved the analysis of cross-sectional baseline data from a prospective database of 548 women (87% consent rate) recruited from December 2013 through April 2015 at a tertiary referral center for endometriosis and/or pelvic pain. Exclusion criteria included menopausal status, age at least 50 years, previous hysterectomy or oophorectomy, and not sexually active. We performed a standardized endovaginal ultrasound-assisted pelvic examination to palpate anatomic structures for tenderness and reproduce deep dyspareunia. Multivariable regression was used to determine which tender anatomic structures were independently associated with deep dyspareunia severity and to identify clinical factors independently associated with each tender anatomic site.

Main Outcome Measure
Severity of deep dyspareunia on a numeric pain rating scale of 0 to 10.

Results
Severity of deep dyspareunia (scale = 0–10) was independently associated with tenderness of the bladder (b = 0.88, P = .018), pelvic floor (levator ani) (b = 0.66, P = .038), cervix and uterus (b = 0.88, P = .008), and cul-de-sac or uterosacral ligaments (b = 1.39, P &lt; .001), but not with the adnexa (b = −0.16, P = 0.87). The number of tender anatomic sites was significantly correlated with more severe deep dyspareunia (Spearman r = 0.34, P &lt; .001). For associated clinical factors, greater depression symptom severity was specifically associated with tenderness of the bladder (b = 1.05, P = .008) and pelvic floor (b = 1.07, P &lt; .001). A history of miscarriage was specifically associated with tenderness of the cervix and uterus (b = 2.24, P = .001). Endometriosis was specifically associated with tenderness of the cul-de-sac or uterosacral ligaments (b = 3.54, P &lt; .001).

Conclusions
In reproductive-age women at a tertiary referral center, deep dyspareunia was independently associated not only with tenderness of the cul-de-sac and uterosacral ligaments but also with tenderness of the bladder, pelvic floor, and cervix and uterus.
Yong PJ, Williams C, Yosef A, et al. Anatomic Sites and Associated Clinical Factors for Deep Dyspareunia. Sex Med 2017;5:e184–e195.