bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connection between autoimmune disease and pelvic neuropathic pain by vascular entrapment - a review of 128 consecutive patients
Authors: Possover Marc , Abrao Henrique 
Published: October 2024

Abstract

This retrospective analysis investigates the relationship between autoimmune diseases and pelvic neuropathies caused by vascular entrapment, a condition often misdiagnosed as "Chronic Pelvic Pain Syndrome of unknown origin." The study analyzed 128 female patients who underwent laparoscopic nerve decompression at the Possover International Medical Center. The average age of the patients was 42 years, with 33% having a history of autoimmune diseases, predominantly hypermobility spectrum disorder (HSD) and Ehlers-Danlos syndrome (EDS), which were present in 21.87% of cases. Intraoperative findings revealed vascular entrapment in all patients, with aberrant or enlarged blood vessels being the most common anomalies. Bilateral vascular entrapment was observed in 80% of the cases. These results suggest a significant association between autoimmune diseases and pelvic neuropathies due to vascular entrapment. The findings underscore the importance of a comprehensive patient history, particularly concerning autoimmune and hematologic conditions, in the accurate diagnosis and treatment of pelvic neuropathies. Rheumatologists should consider the possibility of vascular entrapment in patients with autoimmune diseases, especially those with EDS, who report neuropathic pelvic or sciatic pain that improves when lying down. This awareness could lead to more accurate diagnoses and improved patient outcomes in cases of intractable pelvic neuropathy.
Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization
Authors: Puthanveettil Sathyanarayanan , Wingfield Jenna , Niese Lukas , Diez Stefan 
Published: October 2024

Abstract

Precise control of axonal and dendritic architecture is vital for proper brain function, with microtubule (MT) dynamics playing a central role in this process. Here, we uncover a previously unrecognized function of the molecular motor protein KIF11, which acts as a MT dynamics rheostat in hippocampal neurons to modulate dendritic branching. Known for its role in mitotic spindle bipolarity, KIF11 is also implicated in Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disabilities (MCLID). However, the specific neuronal functions of KIF11 and the impact of its mutations in MCLID have remained largely unexplored. Our studies, using quantitative imaging of MT dynamics following KIF11 inhibition, indicate that KIF11 preferentially binds to parallel MTs in mature neurons. This binding is associated with a marked increase in minus-end-out MT dynamics in both axons and dendrites upon KIF11 loss of function, coupled with enhanced MT flux and extended growth in tertiary dendrites. These changes suggest a novel role for KIF11 in orchestrating dendritic branching. Moreover, introducing MCLID-associated KIF11 mutations, KIF11Y82F, and KIF11ΔCterm, which cause minor microcephaly but severe intellectual disabilities, leads to significantly reduced MT dynamics and impaired dendritic arborization. In a microtubule sliding assay, KIF11Y82F significantly reduced KIF11 velocity while KIF11ΔCterm increased it. Temporal inhibition of KIF11 using a photo-inhibitable KIF11, show increased MT dynamics and dendritic growth, while activation results in kinked and twisted branches. Together, these data reveal that KIF11 is MT dynamics rheostat and regulator of dendritic arborization in mature neurons and provide new insights into the molecular mechanisms driving MCLID.
A visual analysis of the research hotspot and trend of oral cancer patients nursing based on Citespace
Authors: Liu Ping , Pei Saimin , Tong Li , Chen Lijun , Gu Mengjiao , Deng Lingyan 
Published: October 2024

Abstract

Objective To analyze the hotspot and trend of nursing care of patients with oral cancer by visualization method.Methods The literature related to the nursing of oral cancer patients in the core database of the Web of Science was systematically searched from January 1, 1978 to May 27, 2024. CiteSpace6.1.R6 software was used to visualize the authors, institutions, co-citations and keywords of the included documents.Results A total of 1154 literatures were included, and the number of published literatures showed an increasing trend. The United States had the highest number of publications, followed by the United Kingdom and China. The Journal with the most citations was the Journal Of Clinical Oncology (395 times), while the journal with the highest centrality of citations was The Lancet (0.13). The top five keywords were cancer (224 times), chemotherapy (154 times), care (126 times), quality of life (124 times) and management (123 times). A total of 8 significant clusters were formed, which could be summarized into ① different treatment methods and schemes; ② prevention of oral cancer; ③ symptomatic treatment of cancer pain; ④ prevention and treatment of complications. The research trends and directions in recent years mainly include education, outcome, impact and dysphagia, especially dysphagia.Conclusion The contents of nursing research on patients with oral cancer are rich, mainly in treatment methods; Prevention; Treatment of cancer pain and prevention of complications. Current research trends focus on education, outcomes, impact, dysphagia, and specifically dysphagia.
Translation and validation of the Caffeine Use Disorder Questionnaire (CUDQ) in Arabic
Authors: Fekih-Romdhane Feten , Hallit Rabih , Malaeb Diana , Sakr Fouad , Dabbous Mariam , Obeid Sahar , Hallit Souheil 
Published: October 2024

Abstract

Background
Due to the elevated global prevalence of its consumption, and the detrimental health effects it can have, CUD should receive a great deal of attention from clinicians and the research community in Arab countries as an area of concern. To help advance the field, this study aimed to translate the Caffeine Use Disorder Questionnaire (CUDQ) into the Arabic language, and examine its psychometric properties in community adults.
Methods
A descriptive, observational and cross-sectional study was carried out during the period from May to July 2024. Arabic-speaking adults from the general population of Lebanon (N = 1858, 49.8% males, mean age of 30.05 ± 11.39 years), reporting caffeine consumption at least once during the last 12 months, were included.
Results
The study’s results provided support to the theoretical assumptions of unidimensionality of the original version of the CUDQ, with excellent composite reliability (Cronbach’s α = .90). Furthermore, the structure of the Arabic CUDQ was equivalent across sex, suggesting that the latent CUD construct has the same meaning in male and female adults. The highest CUDQ scores were reported by participants drinking 7 to 9 cups and 10 cups or more of coffee/per day relative to those consuming lower amounts of coffee. Finally, our findings revealed good concurrent validity based on positive correlations of CUDQ scores with nicotine dependence, depression and anxiety scores.
Conclusion
Overall, findings suggest that the CUDQ is appropriate and suitable for use to measure CUD among Arabic-speaking adults from the general population. Making the CUDQ available in the Arabic language can fill a gap in the assessment of problematic caffeine consumption in Arab contexts. Future studies are required to further confirm the psychometric soundness of the Arabic CUDQ in more representative samples, specific populations and other Arab countries
Determinants Underlying Teenager’s Accessibility to Contraceptive Methods and HIV Preventive Measures in Rwamagana District, Rwanda
Authors: Rumenge Nt. Alain , Batamuriza Myriam , Benimana Immaculate , Bikorimana Emmanuel , Gasurira Sylvestre , Mukiza Amani , Buser Julie M. 
Published: October 2024

Abstract

Background: In Rwanda, despite significant political achievements in women's empowerment and efforts to eliminate child sexual abuse, the rate of teenage pregnancy remains high. Increased access to and use of contraceptive methods could reduce the rates of teenage pregnancy and HIV infection.
Objectives: This study aims to assess the determinants, needs, and barriers to the use of contraceptive methods and HIV/AIDS preventive services by adolescents in Rwamagana District, Rwanda.
Methods: A cross-sectional design was used in this study. A multistage sampling strategy with a simple random technique was employed to select 376 female students as participants. Data were collected using a pretested questionnaire composed of closed-ended questions with Likert scale constructs based on the Theory of Planned Behavior. Descriptive statistics, bivariate analysis, and multivariable logistic regression were conducted.
Results: A multiple logistic regression analysis shows that participants aged 18–20 are more than twice as likely to use contraceptive methods or HIV preventive measures compared to those aged 13–15 (OR=2.876, P=0.041, 95% CI=1.974–4.052). Urban participants are also more than twice as likely to use contraceptives or HIV preventive methods compared to those whose schools are in rural areas (OR=2.333, P=0.037, 95% CI=1.261–4.316). Female students in Senior 6 are more than three times as likely to use contraceptive methods or HIV preventive measures compared to those in Senior 1 (OR=3.444, P=0.032, 95% CI=2.544–6.884).
Participants who intend to have sex at an older age had a 24.9% reduction in the odds of using a contraceptive method or HIV preventive measures (OR=0.751, P=0.033, 95% CI=0.352–0.977). Friends of respondents also influence contraceptive use (OR=0.611, P=0.043, 95% CI=0.252–0.917). Participants with contraceptive knowledge are three times more likely to use contraceptives or HIV preventive methods compared to those with less contraceptive knowledge (OR=3.096, P=0.011, 95% CI=1.150–6.803).
Conclusion: Area of residence, age, friendships, and knowledge of contraceptive methods and HIV preventive measures are the determinants underlying early sexual activity among teenagers. One of the biggest challenges is the level of sex education, which remains a taboo topic in Rwandan culture. It is still difficult for parents to discuss sex directly with their children. We recommend further studies to focus on teenage non-scholars while conducting similar research.
Predicting Pulmonary Fibrosis Progression in Coalworker Pneumoconiosis Using a CT Radiomics and Clinical Features Model
Authors: Wang Wei , Xie Xinyi , Li Qian , Bi Chaohu , Wen Yao , Su Jing , Huang Jiao , Xie Wutao 
Published: October 2024

Abstract

Objective
This study aimed to construct a machine learning model based on CT radiomics combined with clinical features to predict the progression of pulmonary interstitial fibrosis in coalworker pneumoconiosis.
Methods
The clinical and imaging data of 297 patients diagnosed with coalworker pneumoconiosis by the expert panel of The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College from December 2021 to December 2023 were analysed. Among these patients, 170 progressed to pulmonary interstitial fibrosis during a three-year follow-up period and were classified as the progression group, while the remaining 127 were classified as the stable group. Patients were assigned to a training cohort (n = 207) and a test cohort (n = 90). Radiomic features were extracted from the CT images of lung tissue fibrosis lesions in the training cohort. These features were then subjected to dimensionality reduction to construct morphological biomarkers. Machine learning methods were used to construct a clinical model, a radiomics model, and a multimodal joint model. The performance of these models was evaluated in the test cohort using receiver operating characteristic (ROC) curves and decision curve analysis (DCA).
Results
In the training cohort, the area under the curve (AUC) of the ROC curves for the clinical, radiomic, and joint models were 0.835, 0.879, and 0.945, respectively. In the test cohort, the AUC values for the clinical, radiomic, and joint models were 0.732, 0.750, and 0.845, respectively. The joint model showed the best predictive efficacy and clinical benefit in both the training and test cohorts.
Conclusion
The joint model based on CT radiomics and clinical features could accurately predict the progression of pulmonary fibrosis in coalworker pneumoconiosis.
Sustained vascular inflammatory effects of SARS-CoV-2 spike protein on human endothelial cells
Authors: Gultom Mitra , Lin Lin , Brandt Camilla Blunk , Milusev Anastasia , Despont Alain , Shaw Jane , Döring Yvonne , Luo Yonglun , Rieben Robert 
Published: October 2024

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with systemic inflammation and vascular injury, which contribute to the development of acute respiratory syndrome (ARDS) and the mortality of COVID-19 infection. Moreover, multiorgan complications due to persistent endothelial dysfunction have been suspected as the cause of post-acute sequelae of SARS-CoV-2 infection. Therefore, elucidation of the vascular inflammatory effect of SARS-CoV-2 will increase our understanding of how endothelial cells (EC) contribute to the short- and long-term consequences of SARS-CoV-2 infection. Here, we investigated the interaction of SARS-CoV-2 spike protein with human ECs from aortic (HAoEC) and pulmonary microvascular (HPMC) origins, cultured under physiological flow conditions. We showed that the SARS-CoV-2 spike protein triggers prolonged expression of cell adhesion markers in both ECs, similar to the effect of TNF-α. SARS-CoV-2 spike treatment also led to the release of various chemokines observed in severe COVID-19 patients. Moreover, increased binding of leucocytes to the endothelial surface and a procoagulant state of the endothelium were observed. Transcriptomic profiles of SARS-CoV-2 spike-activated HPMC and HAoEC showed prolonged upregulation of genes and pathways associated with responses to virus, cytokine-mediated signaling, pattern recognition, as well as complement and coagulation pathways. Our findings support experimental and clinical observations of the vascular consequences of SARS-CoV-2 infection and highlight the importance of EC protection as one of the strategies to mitigate the severe effects as well as the possible post-acute complications of COVID-19 disease.
Nitric Oxide: A Novel Therapeutic Target for Salt-Induced Nocturnal Polyuria in Aging
Authors: Takezawa Kentaro , Imanaka Takahiro , Kujime Yuma , Kitakaze Hiroaki , Tsujimura Go , Kuribayashi Sohei , Sekii Yosuke , Ueda Norichika , Fukuhara Shinichiro , Kiuchi Hiroshi , Negoro Hiromitsu , Nonomura Norio 
Published: October 2024

Abstract

Nocturnal polyuria is a major cause of nocturia, which affects quality of life. Aging-related decreases in nitric oxide production have been reported to contribute to salt-induced nocturnal polyuria. We posited that enhanced nitric oxide production from exercise could mitigate salt-induced nocturnal polyuria. To validate, we assessed the impact of exercise on intrarenal renin-angiotensin system activity and salt-induced polyuria during inactive periods in aged mice. We found an increase in nitric oxide production by moderate-intensity exercise suppressed the intrarenal renin-angiotensin system and improved salt-induced polyuria during inactive periods in aged mice. These effects were neutralized by nitric oxide synthesis inhibition. These findings indicate that exercise-induced improvements in salt-induced polyuria during inactive periods are caused by increases in nitric oxide production. In summary, increasing nitric oxide production may serve as a treatment method for salt-induced nocturnal polyuria in older adults.
Safety and efficacy of arthroscopic-assisted uni-portal spinal surgery combined with bone anchoring annulus fibrosus suture technique for treatment of lumbar disc herniation with vertebral edge annulus fibrosus tear
Authors: Xia Gushang , Song En , Li Xianglin , Kong Qingli , Sun Fei , Shao Jiannan , Lu Shaokun , Yang Rong , Zhang Liming , Zhou Yusong 
Published: October 2024

Abstract

Objective: To investigate the safety and clinical effectiveness of Arthroscopic-assisted Uni-portal Spinal Surgery(AUSS)combined with bone anchoringannulus fibrosus suture technique in the treatment of lumbar disc herniation(LDH) with vertebral edge annulus fibrosus tear.
Methods: A total of 52 patients with LDH with vertebral edge annulus fibrosus tear from March 2019 to March 2023 in our hospital were included in this study.All patients were treated by AUSS combined with bone anchoring annulus fibrosus suture technique.The visual analog scale (VAS) score for lower back and lower limb pain and the oswestry disability index (ODI) were used to compare before operation and 1 month, 6 months and 12 months after operation. The clinical efficacy was evaluated by modified MacNab efficacy standard at 12 months after operation.
Results: All patients completed the operation successfully and obtained follow-up results, the average follow-up time was 13.8 months (range, 12-18 months).The average operation time was 105 minutes (range, 68-143 minutes).There were 2 cases of dural sac tear during operation,one patient had aggravation of pain and numbness in the ipsilateral lower limb and hypoesthesia in the perineal region after operation,one patient developed postoperative incision infection.The incidence of complications was 7.69%. One month after operation,the VAS scores for lower back and lower limb pain and ODI were signifcantly lower than before the operation (P<0.05).The above indicators continued to improve at 6 months and 12 months after operation, and the differences were significant (P<0.05).According to the modified MacNab efficacy standard at 12 months after operation, 41 cases were excellent, 9 cases were good, and 2 cases were acceptable, with an excellent and good rate of 96.15%. No recurrence was observed.
Conclusion:AUSS combined with bone anchoring annulus fibrosus suture technique is a safe and effective surgical method for the treatment of LDH with vertebral edge annulus fibrosus tear.It can effectively reduce the recurrence rate, achieve a high excellent and good rate and good clinical efficacy ,which is worthy of clinical promotion.
Network homeostasis: functional brain network alterations and relapse in remitted late-life depression
Authors: gerlach andrew , Karim Helmet T , kolobaric antonija , boyd brian , Kahru Kevin , Krafty Robert , Ajilore Olusola , Talyor Warren , Andreescu Carmen 
Published: October 2024

Abstract

In this study, we aim to identify neurobiological factors that predict relapse risk in late-life depression (LLD). We recruited 145 older adults (age ≥ 60): 102 recently remitted LLD participants and 43 healthy comparisons. Participants underwent baseline MRI and evaluation of depression symptoms/status for up to 2 years. We evaluated intrinsic network connectivity for 111 participants (39 healthy comparisons, 47 stable remitted, 25 relapsed). LLD participants had lower connectivity primarily within and between the default mode (DMN), somatomotor, and visual networks and higher connectivity between the DMN and executive control network. Lower connectivity of DMN to somatomotor and salience networks was associated with relapse. Notably, the network structure of relapsed participants was more similar to healthy comparisons than stable remitted. These findings indicate that remission is associated with persistent functional network alterations while vulnerability to relapse may be associated with a failure to establish a new stable homeostatic functional network structure.
Clinical management of patients with advanced HIV disease at The AIDS Support Organization, Mbarara clinic in Southwestern Uganda: a retrospective review of patient records
Authors: Tukamuhebwa Paddy Mutungi , Gemmell Isla 
Published: October 2024

Abstract

Introduction: Uganda has made significant progress in expanding access to ART over the years, however, currently up to 50% of PLHIV still enroll into HIV care with AHD. PLHIV who present with AHD continue to have a greater mortality risk and the risk rises as CD4 counts drop, particularly if they fall below 100 cells per cubic millimeter. This study therefore seeks to evaluate the clinical management practices for AHD at a high volume not for profit health facility in an urban setting in Southwestern Uganda. Methods: A cross-sectional analysis of secondary data from a large volume, nonprofit health facility in Southwestern Uganda was done. An analysis included patient records of 994 new and 76 virologically non suppressed patients. Descriptive analysis of data was done, and the two groups (treatment naïve and non-suppressed) were compared using chi-square tests or Fisher’s exact test for categorical data and the Mann Whitney U test for numerical data. The analysis was done using StatsDirect. Results: The prevalence of ADH as defined by a CD4 cell count below 200 cells/µl or WHO clinical stage 3 or 4 disease was 20.4% (95% CI: 18.0—23.0). The prevalence of AHD was considerably higher among males 30.3% (95% CI: 26.1—35.0%) compared to females: 13.9% (95% CI: 11.2—17.0%). Access to CD4 as a diagnostic test for AHD was 74.5% (741/994) among newly enrolled patients compared to 77.6% (59/76) among virally non suppressed patients. Access to serum CrAg screening among patients with AHD was higher among the newly enrolled HIV clients at 60.6% (131/216) compared to non-suppressed clients; 22.2% (6/27) (p < 0.001). Additionally, there was no significant difference in administration of fluconazole between the two groups (p = 0.476). Among the patients with AHD, the proportion of patient tested for TB using urine TB_LAM was higher among the newly enrolled patients (45.9%) compared to the non-suppressed clients (21.4%), and this difference was statistically significant (p = 0.010). Conclusion: This study demonstrates that much as significant strides have been made in the achievement of the UNAIDS 95 95 95 targets, the prevalence of AHD remains high, and the implementation of the AHD intervention package remains sub-optimal. The Ministry of Health and partners need to strengthen processes for the screening, diagnosis, and management of AHD. Clinical trial number: Not applicable.
Association between non-inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study
Authors: Xiong Xiaojuan , Li Ting , Yu Shuang , Mao Qingxiang 
Published: October 2024

Abstract

Purpose: To investigate the association between non-inflammatory indices-systemic immune-inflammation index (SII), monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and preoperative deep vein thrombosis (DVT) in patients undergoing total joint arthroplasty (TJA).
Methods: A total of 2125 patients were enrolled. We created the receiver operator characteristic (ROC) curve using the ratios of SII, MLR, NLR, PLR to DVT before TJA, divided the enrolled patients into groups based on the cut-off value, and then analyzed risk factors for DVT before TJA in the multivariate binary logistic regression analysis.
Results: Preoperative DVT occurred in 110 cases (5.18%). Based on the ROC curve, we determined that the cut-off values for SII, MLR, NLR, and PLR were 470*109 /L, 0.306, 2.08, and 127; and the areas under the curve (AUC) were 0.623, 0.601, 0.611, and 0.62. Multivariate binary regression analysis revealed that the risk of preoperative DVT in TJA patients with SII ≥ 470*109/L, MLR ≥ 0.306, PLR ≥ 127, and NLR ≥ 2.08 increased by 2.26 (P<0.001, 95% confidence interval (CI) [1.52-3.37]), 1.92 (P=0.002, 95% CI [1.28-2.9]), 2.1 (P<0.001, 95% CI [1.4-3.16]), and 1.94 (P=0.002, 95% CI [1.29-2.92]) times, respectively. Age, P < 0.001, odds ratio (OR)=1.08, 95%CI [1.05-1.10]; corticosteroid use, P=0.002, OR 3.8, 95% CI [1.94-9.22]).
Conclusion: We found that higher SII, MLR, NLR, and PLR levels, age, and corticosteroid use were independent risk factors for preoperative DVT in patients undergoing TJA.
Trial registration: ChiCRT2100054844