bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-Step Treatment for Patellar Cartilage Defects With a Cell-Free Osteochondral Scaffold: A Prospective Clinical and MRI Evaluation
Authors: Perdisa Francesco , Filardo Giuseppe , Sessa Andrea , Busacca Maurizio , Zaffagnini Stefano , Marcacci Maurilio , Kon Elizaveta 
Published: March 2017

Background:The treatment of symptomatic cartilage defects of the patella is particularly challenging, and no gold standard is currently available.Purpose:To evaluate the clinical results of a biphasic cell-free collagen-hydroxyapatite scaffold and to evaluate osteochondral tissue regeneration with magnetic resonance imaging (MRI).Study Design:Case series; Level of evidence, 4.Methods:Thirty-four patients (18 men and 16 women; mean ± SD: age, 30.0 ± 10 years) were treated by scaffold implantation for knee chondral or osteochondral lesions of the patella (area, 2.1 ± 1 cm2). The clinical evaluation was performed prospectively at 12 and 24 months via the IKDC (International Knee Documentation Committee; objective and subjective) and Tegner scores. MRI evaluation was performed at both follow-ups in 18 lesions through the MOCART score (magnetic resonance observation of cartilage repair tissue) and specific subchondral bone parameters.Results:A statistically significant improvement in all the scores was observed at 12- and 24-month follow-up as compared with the basal evaluation. The IKDC subjective score improved from 39.5 ± 14.5 to 61.9 ± 14.5 at 12 months ( P > .0005) with a further increase to 67.6 ± 17.4 at 24 months of follow-up (12-24 months, P = .020). The MRI evaluation showed a stable value of the MOCART score between 12 and 24 months, with a complete filling of the cartilage in 87.0% of the lesions, complete integration of the graft in 95.7%, and intact repair tissue surface in 69.6% at final follow-up. The presence of osteophytes or more extensive bony overgrowth was documented in 47.8% of the patients of this series, but no correlation was found between MRI findings and clinical outcome.Conclusion:The implantation of a cell-free collagen-hydroxyapatite osteochondral scaffold provided a clinical improvement at short-term follow-up for the treatment of patellar cartilage defects. Women had lower outcomes, and the need for realignment procedures led to a slower recovery. MRI evaluation showed some abnormal findings with the presence of bone overgrowth, but no correlation has been found with the clinical outcome.
Systematic Review of Social–Emotional Screening Instruments for Young Children in Child Welfare
Authors: McCrae Julie S. , Brown Samantha M. 
Published: March 2017

Purpose: The Child Abuse Prevention and Treatment Act requires child welfare agencies to have provisions in place to refer young children to early intervention services, yet the socioemotional health needs of children are often challenging to recognize and treat effectively. This study reviews the substantive and psychometric properties of screening instruments designed for children ages 10 and younger. Methods: Major social science databases, websites of national organizations, and the Mental Measurements Yearbook were used to identify instruments for review. Results: Twenty-four instruments met review criteria, and eight show above-average measurement properties and testing, tap children’s strengths and concerns, and have evidence of validity with families similar to child welfare–involved families. Discussion: It is important to effectively screen for children showing concerns in early childhood, so that treatment and prevention can be prioritized. This study indicated several tools with adequate testing and with emerging evidence and applicability to child welfare.
Metastatic pulmonary carcinomas in cats (‘feline lung–digit syndrome’): further variations on a theme
Authors: Thrift Elizabeth , Greenwell Chris , Turner Audra-Lynne , Harvey Andrea M , Maher Donna , Malik Richard 
Published: March 2017

Case series summary The aim of this retrospective case series was to describe seven cases where cats with primary lung tumours were presented because of metastases to extra-pulmonary sites (‘feline lung–digit syndrome’). Specifically, we wanted to emphasise less typical case descriptions where tumour emboli resulted in lesions developing in the musculature (including the muscles of the head), skin or distal aorta. Relevance and novel information The cases are presented to increase clinical awareness of this entity in feline practice, especially when characteristic combinations of clinical signs are present. When clinicians have a high index of suspicion for these presentations, radiology (thorax and digits) or ultrasound (distal aorta), combined with collection of fine needle aspirate specimens for cytology, are usually sufficient to secure a definitive diagnosis. Novel information in this series includes CT and MRI findings from some cases. Typically, needle aspiration or biopsy targeting the skin, digits and lesions in musculature is far easier compared with sampling the primary tumour site in the lungs. The differential diagnosis and investigation of multiple digital lesions is also considered.
Surgical management of medial humeral epicondylitis, cubital synovial osteochondromatosis and humeroradial subluxation in a cat
Authors: Perry Karen L 
Published: March 2017

Case summary A 13-year-old domestic shorthair cat presented for evaluation of pain and difficulty ambulating. Orthopedic examination and CT facilitated a diagnosis of bilateral elbow synovial osteochondromatosis with medial humeral epicondylitis and concurrent osteoarthritis. Right humeroradial subluxation was evident on CT images, but no instability was evident preoperatively. Surgical treatment was elected, including external neurolysis of the ulnar nerve, removal of the areas of mineralization within the flexor carpi ulnaris muscle and medial arthrotomy to remove intra-articular mineralized bodies. Following closure, instability of the right elbow was noted with humeroradial subluxation necessitating placement of circumferential suture prostheses to provide satisfactory stability. Reassessment was performed 2, 6, 12, 24 and 40 weeks postoperatively and revealed maintenance of elbow stability and substantial improvement in mobility and comfort. Relevance and novel information While humeroradial subluxation has been reported in association with medial humeral epicondylitis on post-mortem examination, associated clinically significant instability has not been documented previously. Surgeons should be aware of the potential for this complication and check elbow stability following surgery. Despite this complication, a favorable medium-term outcome was achieved for this cat.
Initial 4D seismic results after CO2 injection start-up at the Aquistore storage site
Authors: Roach Lisa A. N. , White Donald J. , Roberts Brian , Angus Doug 
Published: March 2017

The first post-[Formula: see text]-injection 3D time-lapse seismic survey was conducted at the Aquistore [Formula: see text] storage site in February 2016 using the same permanent array of buried geophones used for acquisition of three previous pre-[Formula: see text]-injection surveys from March 2012 to November 2013. By February 2016, 36 kilotons of [Formula: see text] have been injected within the reservoir between 3170 and 3370 m depth. We have developed time-lapse results from analysis of the first post-[Formula: see text]-injection data and three pre-[Formula: see text]-injection data sets. The objective of our analysis was to evaluate the ability of the permanent array to detect the injected [Formula: see text]. A “4D-friendly simultaneous” processing flow was applied to the data in an effort to maximize the repeatability between the pre- and post-[Formula: see text]-injection volumes while optimizing the final subsurface image including the reservoir. Excellent repeatability was achieved among all surveys with global normalized root-mean-square (G nrms) values of 1.13–1.19 for the raw prestack data relative to the baseline data, which decreased during processing to G nrms values of approximately 0.10 for the final crossequalized migrated data volumes. A zone of high normalized root-mean-square ( nrms) values (0.11–0.25 as compared with background values of 0.05–0.10) is identified within the upper Deadwood unit of the storage reservoir, which likely corresponds to approximately 18 kilotons of [Formula: see text]. No significant nrms anomalies are observed within the other reservoir units due to a combination of reduced seismic sensitivity, higher background nrms values, and/or small quantities of [Formula: see text] residing within these zones.
Telephone-supported computerised cognitive–behavioural therapy: REEACT-2 large-scale pragmatic randomised controlled trial
Authors: Gilbody Simon , Brabyn Sally , Lovell Karina , Kessler David , Devlin Thomas , Smith Lucy , Araya Ricardo , Barkham Michael , Bower Peter , Cooper Cindy , Knowles Sarah , Littlewood Elizabeth , Richards David A. , Tallon Debbie , White David , Worthy Gillian ,   on behalf of the REEACT collaborative
Published: March 2017

BackgroundComputerised cognitive–behavioural therapy (cCBT) for depression has the potential to be efficient therapy but engagement is poor in primary care trials.AimsWe tested the benefits of adding telephone support to cCBT.MethodWe compared telephone-facilitated cCBT (MoodGYM) (n = 187) to minimally supported cCBT (MoodGYM) (n = 182) in a pragmatic randomised trial (trial registration: ISRCTN55310481). Outcomes were depression severity (Patient Health Questionnaire (PHQ)-9), anxiety (Generalized Anxiety Disorder Questionnaire (GAD)-7) and somatoform complaints (PHQ-15) at 4 and 12 months.ResultsUse of cCBT increased by a factor of between 1.5 and 2 with telephone facilitation. At 4 months PHQ-9 scores were 1.9 points lower (95% CI 0.5–3.3) for telephone-supported cCBT. At 12 months, the results were no longer statistically significant (0.9 PHQ-9 points, 95% CI −0.5 to 2.3). There was improvement in anxiety scores and for somatic complaints.ConclusionsTelephone facilitation of cCBT improves engagement and expedites depression improvement. The effect was small to moderate and comparable with other low-intensity psychological interventions.
A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling
Authors: Yamane Masayuki , Yamashita Naoya , Hida Tomonobu , Kamiya Yoshinori , Nakamura Fumio , Kolattukudy Pappachan , Goshima Yoshio 
Published: March 2017

ABSTRACT
Semaphorin3A (Sema3A) is a secreted type of axon guidance molecule that regulates axon wiring through complexes of neuropilin-1 (NRP1) with PlexinA protein receptors. Sema3A regulates the dendritic branching through tetrodotoxin (TTX)-sensitive retrograde axonal transport of PlexA proteins and tropomyosin-related kinase A (TrkA) complex. We here demonstrate that Nav1.7 (encoded by SCN9A), a TTX-sensitive Na+ channel, by coupling with collapsin response mediator protein 1 (CRMP1), mediates the Sema3A-induced retrograde transport. In mouse dorsal root ganglion (DRG) neurons, Sema3A increased co-localization of PlexA4 and TrkA in the growth cones and axons. TTX treatment and RNAi knockdown of Nav1.7 sustained Sema3A-induced colocalized signals of PlexA4 and TrkA in growth cones and suppressed the subsequent localization of PlexA4 and TrkA in distal axons. A similar localization phenotype was observed in crmp1−/− DRG neurons. Sema3A induced colocalization of CRMP1 and Nav1.7 in the growth cones. The half maximal voltage was increased in crmp1−/− neurons when compared to that in wild type. In HEK293 cells, introduction of CRMP1 lowered the threshold of co-expressed exogenous Nav1.7. These results suggest that Nav1.7, by coupling with CRMP1, mediates the axonal retrograde signaling of Sema3A.
The impact factor of an open access journal does not contribute to an article’s citations
Authors: Chua SK , Qureshi Ahmad M , Krishnan Vijay , Pai Dinker R , Kamal Laila B , Gunasegaran Sharmilla , Afzal MZ , Ambawatta Lahiru , Gan JY , Kew PY , Winn Than , Sood Suneet 
Published: March 2017

Background Citations of papers are positively influenced by the journal’s impact factor (IF). For non-open access (non-OA) journals, this influence may be due to the fact that high-IF journals are more often purchased by libraries, and are therefore more often available to researchers, than low-IF journals. This positive influence has not, however, been shown specifically for papers published in open access (OA) journals, which are universally accessible, and do not need library purchase. It is therefore important to ascertain if the IF influences citations in OA journals too. Methods 203 randomized controlled trials (102 OA and 101 non-OA) published in January 2011 were included in the study. Five-year citations for papers published in OA journals were compared to those for non-OA journals. Source papers were derived from PubMed. Citations were retrieved from Web of Science, Scopus, and Google Scholar databases. The Thompson-Reuter’s IF was used. Results OA journals were found to have significantly more citations overall compared to non-OA journals (median 15.5 vs 12, p=0.039). The IF did not correlate with citations for OA journals (Spearman’s rho =0.187, p=0.60). The increase in the citations with increasing IF was minimal for OA journals (beta coefficient = 3.346, 95% CI -0.464, 7.156, p=0.084). In contrast, the IF did show moderate correlation with citations for articles published in non-OA journals (Spearman’s rho=0.514, p<0.001). The increase in the number of citations was also significant (beta coefficient = 4.347, 95% CI 2.42, 6.274, p<0.001). Conclusion It is better to publish in an OA journal for more citations. It may not be worth paying high publishing fees for higher IF journals, because there is minimal gain in terms of increased number of citations. On the other hand, if one wishes to publish in a non-OA journal, it is better to choose one with a high IF.
dbVar structural variant cluster set for data analysis and variant comparison
Authors: Phan Lon , Hsu Jeffrey , Tri Le Quang Minh , Willi Michaela , Mansour Tamer , Kai Yan , Garner John , Lopez John , Busby Ben 
Published: March 2017

dbVar houses over 3 million submitted structural variants (SSV) from 120 human studies including copy number variations (CNV), insertions, deletions, inversions, translocations, and complex chromosomal rearrangements. Users can submit multiple SSVs to dbVAR that are presumably identical, but were ascertained by different platforms and samples, to calculate whether the variant is rare or common in the population and allow for cross validation. However, because SSV genomic location reporting can vary – including fuzzy locations where the start and/or end points are not precisely known – analysis, comparison, annotation, and reporting of SSVs across studies can be difficult. This project was initiated by the Structural Variant Comparison Group for the purpose of generating a non-redundant set of genomic regions defined by counts of concordance for all human SSVs placed on RefSeq assembly GRCh38 (RefSeq accession GCF_000001405.26). We intend that the availability of these regions, called structural variant clusters (SVCs), will facilitate the analysis, annotation, and exchange of SV data and allow for simplified display in genomic sequence viewers for improved variant interpretation. Sets of SVCs were generated by variant type for each of the 120 studies as well as for a combined set across all studies. Starting from 3.64 million SSVs, 2.5 million and 3.4 million non-redundant SVCs with count >=1 were generated by variant type for each study and across all studies, respectively. In addition, we have developed utilities for annotating, searching, and filtering SVC data in GVF format for computing summary statistics, exporting data for genomic viewers, and annotating the SVC using external data sources.
Problems and Methods of Oil Sludge Treatment
Authors: Сеник  , Senik E. , Воропаева  , Voropaeva A. , Таранов  , Taranov R. , Козодаев  , Kozodaev A. , Ксенофонтов  , Ksyenofontov Boris , Виноградов  , Vinogradov M. 
Published: March 2017

Urgency of the problem of sludge treatment and disposal in recent times is noted in this paper. Questions related to sludge and other waste treatment by centrifugation both with pre-treatment, and without it, have been considered. It has been demonstrated that the treatment is more effective at heating of above-noted waste, and by reagents adding. As a result of use of centrifuges at a stage of above-noted waste treatment it is possible to reach rather high degree of separation into liquid and firm phases which can be used in various directions. Further dewatering is possible by using a proposed drying scheme with a closed circuit of heat transfer fluid. The scheme includes a unit for heat transfer fluid preparation, a drying chamber, a device for a finished product unloading, a cleaning system for used drying agent, a unit for additional cleaning of heat transfer fluid, dual-circuit system of pneumatic transport for the finished product. The proposed scheme contributes
to exclusion of sludge’ toxic substances from getting into the environment. Experimental studies of activated sludge suspension thickening process after secondary clarifiers in centrifuges of different
types have been carried out. Tests were conducted on laboratory and industrial direct-flow and counter-flow centrifuges. Optimal parameters and modes for centrifugation and thermo-reactant treatment were selected. Effectiveness of preliminary thermo-reactant treatment at a predetermined optimal centrifugation mode for activated sludge has been confirmed. The solids content in the concentrate of microbial biomass at the load 10–13 m3/h reached 9–10 % DIA. At the maximum capacity was used one nozzle with 6 mm diameter. Minimum specific dosage of flocculent is about 2 kg per 1 ton of dry product.
HISTORICAL REVIEW OF DESIGN DEVELOPMENT OF MOTOR CAR GEARBOXES
Authors: Кучкаров Владимир , Kuchkarov Vladimir , Демидов Дмитрий , Demidov Dmitriy 
Published: March 2017

The paper reports the review in the development of motor car gearbox design. The main task consists in the detection of the reasons for changes in gearbox design for the definition of the field for gearbox substantiated application in motor car design.
In the main part the advantages and shortcomings of manual, automated, infinitely variable and automatic gearboxes are under consideration. There are shown and analyzed functional diagrams of gearbox designs considered.
In the conclusion it is pointed out that the most promising design of a gearbox is a robot gearbox with two clutches allowing the assurance of the absence of power flow break; the smoothness of gear shifts and smoothness of motion; comfort of control; high fuel efficiency; high tractiondynamic characteristics.
Assessment of Carbon Status in Marine Protected Area of Payung Island Waters, South Sumatera Province, Indonesia
Authors: Purwiyanto Anna Ida Sunaryo , Agustriani Fitri 
Published: March 2017

CO2 is a greenhouse gas that receive more attention than the other gases because the properties of carbon easily deformed and diffuseed. Changes in the concentration of CO2 in the water will impact on changes in the amount of CO2 in the atmosphere that affect sea surface temperatures. It continuously will result in a change of marine capture fisheries. Payung Island is one of the important areas in South Sumatra that acts as the provider of the fishery. This because Payung Island is located in the mouth of Musi and Telang River covered by mangrove, has a very important ecological function. However, the condition of the carbon in the waters of the Payung Island has not explored further. This elementary study is to determine status on Payung Island waters as a sink or source of CO2. The study was conducted in June until August 2015. The research stages include surface water sampling, measurement of the CO2 in the atmosphere, the analysis of the concentration of Dissolved Inorganic Carbon (DIC) and Total Alkalinity (TA), and partial pressure of carbon dioxide (pCO2) calculation. Atmospheric CO2 were measured insitu, while the DIC and TA were analyzed using titration methods. Partial pressure of carbon dioxide (pCO2) obtained from the calculation using the software CO2Calc using data of DIC, TA, nutrients and atmospheric CO2. The results showed that the content of DIC and TA on the Payung Island waters has similar distribution pattern i.e. high in areas close to the river, and getting lower in the area which were closer to the sea. The comparisons between pCO2 atmosphere and pCO2 waters showed that Payung Island waters generally act as a carbon sink in area towards the sea but however, in the territorial waters adjacent to the river as a source of carbon. Keywords: carbon, marine protected area, Payung Island waters
Bioactive Cembranoid Composition in the Soft Coral of Sarcophyton glaccum on The Response to Changing pH
Authors: Januar Hedi Indra , Zamani Neviaty Putri , Soedharma Dedi , Chasanah Ekowati 
Published: March 2017

Soft coral is predicted to outcompete with hard coral in future ocean acidification scenarios. Beside the biological resilience shown in acidic conditions, soft corals ability to maintain or compete for space is shown to relate with their ability to produce cytotoxic cembranoid-type compounds. The aim of this study was to investigate composition of cytotoxic cembranoid compounds of Sarcophyton glaccum soft coral exposed to current and predicted future ocean acidification scenarios. Sarcophyton glaccum colonies were acclimated along a pH gradient to simulate predicted increases in ocean acidification: natural/current (pH 8,2), slight increase in acidification (pH 8.0 year-1 2060), and moderate increase in acidification (pH 7,8 year­-1 2100). Cembranoid composition was determined by quantitative Nuclear Magnetic Resonance spectroscopy while cytotoxic activity was determined against tumor cell lines. Results of the study showed cytotoxicity and sarcophytoxide (the most active cembranoid compound in observed Sarcophyton glaccum) were both found to be higher at pH 8,0. However, a further increase of acidification resulted on a reduction of both the cytotoxicity and sarcophytoxide production. This suggests that acidification pressures affect directly the defense system metabolism of Sarcophyton glaccum and that while they may be resilient to small decreases in pH, their ability to compete for space may be hampered by more pronounced changes. Keywords: Cembranoids; Cytotoxic; Sarcophyton glaccum; Seawater Acidification; Soft Coral.
Węgierski Październik ’56 oczami dziecka. Trzy (warianty) lektury
Authors: Warmuz Daniel 
Published: March 2017

The purpose of this paper is to demonstrate three possible methods of reading and interpreting three consequent literary works on the Hungarian Revolution of 1956 that describe the events from a perspective of an adolescent boy. The mentioned works are the following: The Radiance of Childhood (Gyermekkor tündoklete) by Istvan Kovacs, Hungarian Revolution 1956: Diary (Magyar Forradalom 1956. Naplo) by Gyula Csics and Kalef by Zsolt Berta. The first demonstrated approach provides a documentary-like look on the October 1956 that is given by dint of (auto)biographical elements or diaristic form. The second method ensures much closer analysis of the Hungarian history across time (before, during and after the Revolution) and space (Hungarian country and Budapest). The third approach targets the aspects of initiation into adulthood, masculinity and Hungarian history of the 20th century that allows to read the three stories as a novels of initiation.