bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing automated guidance for concept diagrams in inquiry instruction
Authors: Ryoo Kihyun , Linn Marcia C. 
Published: April 2016

AbstractAdvances in automated scoring technologies have the potential to support student learning during inquiry instruction by providing timely and adaptive guidance on individual students’ responses. To identify which forms of automated guidance can be beneficial for inquiry learning, we compared reflective guidance to directive guidance for student‐generated concept diagrams in web‐based inquiry instruction. Eleven intact classes were randomly assigned to either a reflective guidance or a directive guidance condition. After creating a concept diagram showing energy flow in life science during the inquiry instruction, the directive group was told specific ways to improve their diagram, while the reflective group was told to revisit a relevant visualization step to locate useful information. The results from the concept diagrams, as well as individual tests, show that both forms of automated guidance helped students add target energy concepts, but reflective guidance was significantly more effective than directive guidance in improving students’ coherent understanding of how energy flows in life science. Analyses of log data revealed that the reflective group was more likely to revisit the visualization step as suggested in the guidance, which significantly enhanced student learning. Detailed analyses suggest that revisiting relevant materials to find useful information challenged students to identify gaps in their understanding and distinguish among multiple ideas. This study shows the value of designing reflective automated guidance for helping students engage in evidence‐gathering practices and enhance their understanding of scientific concepts. The findings suggest promising directions for the design of automated adaptive guidance to support complex science learning. © 2016 Wiley Periodicals, Inc. J Res Sci Teach 53:1003–1035, 2016
Ambient fine particles (PM2.5) attenuate collagen‐induced platelet activation through interference of the PLCγ2/Akt/GSK3β signaling pathway
Authors: Yin Zhao , Xu Hai‐Jiang , Yao Xia‐Li , Liu Gang , Nie Chun‐Jie , Wei Han , Li Cai , Liang Ming‐Lu , Ming Zhang‐Yin , Zhang Xiao‐Jian 
Published: April 2016

ABSTRACTAimsIt has been proven that carbon nanoparticles or diesel exhaust particles stimulate platelet activation. However, the effect of fine particle matter (PM2.5) on platelet activation remains unknown, which motivates this study.MethodsPM2.5 samples were collected in an urban area of Zhengzhou, China. To study the morphological characteristics and the mass concentrations of trace elements of PM2.5 samples, a filed‐emission scanning electron microscope, the Image‐J software, and an inductively coupled plasma mass spectrometry were used. Washed human platelets or platelet‐rich‐plasma were used to study the effect of PM2.5 on platelet aggregation, P‐selectin expression, or platelet signaling pathways. The cytotoxicity in platelets exposed to PM2.5 was evaluated by a lactate dehydrogenase assay kit. In addition, platelet adhesion and spreading were studied on collagen‐coated surfaces in stable conditions.ResultsThe filed‐emission scanning electron microscope scanning showed that PM2.5 samples varied in shape and size distributions. The mean equivalent spherical diameter of these particles was 1.97 ± 0.04 μm, of which 82.40% were particles with equivalent spherical diameters of less than 2.5 μm. The mass concentration of Ca was higher than that of other elements. The other elements followed the trend of Al>Fe>Zn>Mg>Pb>K>Mn>Cu>Ti>Ba>As>Sr>Sn>Sb>Cd>B>Se>Mo>Ag>Ni>TI>V>Co. Furthermore, pretreatment of PM2.5 significantly inhibited rather than potentiated collagen‐induced platelet aggregation and P‐selectin expression, whereas it had no significant effect on ADP‐induced platelet aggregation and P‐selectin expression. The lactate dehydrogenase analysis showed trivial cytotoxic effect of PM2.5 exposure on platelets. Pretreatment of PM2.5 inhibited platelet adhesion on immobilized collagen‐coated surfaces; however, it almost did not impact the platelet spreading. Immunoblotting analysis indicated that PM2.5 reduced collagen‐induced phosphorylation of phospholipase C gamma‐2 (PLCγ2) at Tyr759, Akt at Ser473, and glycogen synthase kinase 3β (GSK3β) at Ser9.ConclusionsPM2.5 attenuated collagen‐induced platelet aggregation, α‐granule secretion and adhesion, with the potential mechanism of impairing PLCγ2, Akt, and GSK3β signaling. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 530–540, 2017.
Thallium(I), Silver(I), and Mixed Thallium(I)/Copper(I) Clusters with Bridging {Me2Si(N‐C6H4‐2‐SPh)2}2– Ligands
Authors: Liebing Phil , Merzweiler Kurt 
Published: April 2016

AbstractThe S‐functionalized aminosilane Me2Si(NH‐C6H4‐2‐SPh)2 (H2L) (1) was prepared from dichlorodimethylsilane and lithiated 2‐(phenylthio)aniline. Treatment of compound 1 with two equivalents of n‐butyllithium led to the dilithium derivative Li2L, which was used in subsequent reactions with MCl (M = Tl, Cu, Ag) to prepare the complexes [Tl2L] (2), [Cu2Tl2L2]·2THF (3a), [Cu2Tl2L2(THF)2] (3b), and [Ag4L2(THT)2] (4) (THT = tetrahydrothiophene). Compound 2 consists of two thallium atoms, which are connected by a L2– ligand to give a puckered Tl2N2 ring with Tl–N distances of 255(1)–268(1) pm. Compounds 3a and 3b are heterobimetallic complexes, which are based on [Cu2L2]2– cores featuring a Cu2N4Si2 ring with linearly coordinated copper atoms [Cu–N: 190.7(3)–192.5(3) pm] and two peripherally attached Tl atoms [Tl–N: 272.7(3)–281.9(3) pm]. The molecular structure of the tetranuclear silver(I) complex 4 is closely related to the structure of compounds 3a and 3b by replacement of the Cu and Tl atoms with Ag atoms. The Ag–N distances are 217.5(3)–245.7(3) pm.
Role of executive attention in consumer learning with background music
Authors: Kang Esther , Lakshmanan Arun 
Published: April 2016

AbstractThis paper examines how the type of background music (vocal vs. instrumental) affects consumers' cognitive performance depending on individual differences in executive attention (i.e., working memory capacity). Across three experiments, we find that vocal music leads to poorer cognitive and attitudinal outcomes for consumers lower in working memory capacity but does not affect those higher in working memory capacity. However, short‐term habituation to background music helps mitigate this negative effect of vocal music on consumer ad recall. Finally, consumer performances on computing discount prices are also affected by music type depending upon whether prices are communicated in verbal or numeric form. Overall, this research lays out an executive‐attention based process mechanism explaining when and how background music shapes consumer learning and memory. The outlined theory enriches the literature on music effects as well as immediate‐term learning by explicating the role of selective attention in the processing of multi‐modal marketing stimuli.
Boundary-Making and Pastoral Conflict along the Kenyan–Ethiopian Borderlands
Authors: Galaty John 
Published: April 2016

Abstract:Boundaries are technologies of power and knowledge that shape spatial and social realities and our understandings of them. This article examines the effects of boundary-making between Kenya and Ethiopia, and investigates the effects of borders on states of peace and conflict among Turkana, Samburu, Borana, Gabra, and Dassanetch of northern Kenya. If borders divide people, people benefit nonetheless from the environmental, social, and political entropy that borders generate by using the energy of spatial differences to advance their own individual and collective life projects.
Expressions of Masculinity and Femininity in Husbands’ Care of Wives with Cancer in Accra
Authors: Atobrah Deborah , Ampofo Akosua Adomako 
Published: April 2016

Abstract:This article explores the care that husbands in Accra, Ghana, provide for wives who have been diagnosed with cancer. Making use of an inductive, qualitative approach, the study analyzes observations of and in-depth ethnographic interviews conducted with five married female cancer patients and their husbands over a ten-month period. The results suggest a strong association among husbands’ care, wives’ responses to husbands’ care, and cultural ideals of femininity and masculinity. The findings suggest that husbands’ selective and often limited gender-based investments in unpaid care work make their sick wives exceedingly vulnerable in a context in which care for the terminally ill takes place predominately in familial settings.
CAEP 2015 Academic Symposium: Recommendations for University Governance and Administration for Emergency Medicine
Authors: Petrie David , Chopra Anil , Chochinov Alecs , Artz Jennifer D. , Schull Michael , Tallon John , Jones Gordon , MacPhee Shannon , Ackerman Margaret , Stiell Ian G. , Christenson Jim 
Published: April 2016

AbstractObjective1) To identify the strengths and challenges of governance structures in academic emergency medicine (EM), and 2) to make recommendations on principles and approaches that may guide improvements.MethodsOver the course of 9 months, eight established EM leaders met by teleconference, reviewed the literature, and discussed their findings and experiences to arrive at recommendations on governance in academic units of EM. The results and recommendations were presented at the annual Canadian Association of Emergency Physicians (CAEP) Academic Symposium, where attendees provided feedback. The updated recommendations were subsequently distributed to the CAEP Academic Section for further input, and the final recommendations were decided by consensus.ResultsThe panel identified four governance areas of interest: 1) the elements of governance; 2) the relationships between emergency physicians and academic units of EM, and between the academic units of EM and faculty of medicine; 3) current status of governance in Canadian academic units of EM; and 4) essential elements of good governance. Six recommendations were developed around three themes, including 1) the importance of good governance; 2) the purposes of an academic unit of EM; and 3) essential elements for better governance for academic units of EM. Recommendations included identifying the importance of good governance, recognizing the need to adapt to the different models depending on the local environment; seeking full departmental status, provided it is mutually beneficial to EM and the faculty of medicine (and health authority); using a consultation service to learn from the experience of other academic units of EM; and establishing an annual forum for EM leaders.ConclusionAlthough governance of academic EM is complex, there are ways to iteratively improve the mission of academic units of EM: providing exceptional patient care through research and education. Although there is no one-size-fits-all guide, there are practical recommended steps for academic units of EM to consider.
Nutrition with Gastrostomy Feeding Tubes for Amyotrophic Lateral Sclerosis in Canada
Authors: Benstead Timothy , Jackson-Tarlton Caitlin , Leddin Desmond 
Published: April 2016

AbstractBackground: Amyotrophic lateral sclerosis (ALS) is a rapidly progressing degenerative motor neuron disease that results in significant muscle weakness. Defects in energy metabolism and difficulties in swallowing eventually lead to a reduction in body mass. Weight loss exacerbates symptoms and serves as an independent negative prognostic factor. Percutaneous endoscopic gastrostomy (PEG) is often inserted in patients with ALS to either supplement or replace oral feeding. However, the criteria for PEG placement and timing of insertion are important clinical decisions that have not been fully studied. Given the absence of guiding evidence, the aim of this project was to better understand how Canadian ALS clinics make decisions regarding gastrostomy feeding. Methods: ALS clinical directors across Canada were asked if they had written guidelines for timing of PEG insertion and if not, what criteria they use to make this decision. Responses from 10 of 17 centres contacted were received. Results: The approach to supplemental nutrition management in Canadian clinics varies in the absence of formal guidelines. Only one centre has a written set of centre-specific protocols in place. Most clinics considered some combination of respiratory decline, weight loss, dysphagia and/or patient readiness when reaching a decision. However, the absolute threshold and mechanism of measuring the individual criteria differed between clinics. Conclusions: Practices generally reflect international published recommendations but vary on the emphasis of specific criteria. Further research is required to determine the optimal timing and criteria to place gastrostomy feeding tubes in the ALS population.
Reevaluating Muscle Biopsies in the Diagnosis of Pompe Disease: A Corroborative Report
Authors: Genge Angela , Campbell Natasha 
Published: April 2016

AbstractBackground: Previous reports suggest that although a diagnostic muscle biopsy can confirm the presence of Pompe disease, the absence of a definitive biopsy result does not rule out the diagnosis. Methods: In this study, we reviewed patients with a limb-girdle syndrome who demonstrated nonspecific abnormalities of muscle, without evidence of the classical changes of acid maltase deficiency. These patients were rescreened for Pompe disease using dried blood spot (DBS) testing. Results: Twenty-seven patients provided blood samples for the DBS test. Four patients underwent subsequent genetic testing. Genetic analysis demonstrated that one patient tested positive for Pompe disease and one patient had one copy of a pathogenic variant. Conclusions: In conclusion, the ability of a diagnostic muscle biopsy to definitively rule out the presence of Pompe disease is limited. There is a role for a screening DBS in all patients presenting with a limb-girdle syndrome without a clear diagnosis.
Neuroradiology Using Secure Mobile Device Review
Authors: Randhawa Privia A. , Morrish William , Lysack John T. , Hu William , Goyal Mayank , Hill Michael D. 
Published: April 2016

AbstractBackground:Image review on computer-based workstations has made film-based review outdated. Despite advances in technology, the lack of portability of digital workstations creates an inherent disadvantage. As such, we sought to determine if the quality of image review on a handheld device is adequate for routine clinical use.Methods:Six CT/CTA cases and six MR/MRA cases were independently reviewed by three neuroradiologists in varying environments: high and low ambient light using a handheld device and on a traditional imaging workstation in ideal conditions. On first review (using a handheld device in high ambient light), a preliminary diagnosis for each case was made. Upon changes in review conditions, neuroradiologists were asked if any additional features were seen that changed their initial diagnoses. Reviewers were also asked to comment on overall clinical quality and if the handheld display was of acceptable quality for image review.Results:After the initial CT review in high ambient light, additional findings were reported in 2 of 18 instances on subsequent reviews. Similarly, additional findings were identified in 4 of 18 instances after the initial MR review in high ambient lighting. Only one of these six additional findings contributed to the diagnosis made on the initial preliminary review.Conclusions:Use of a handheld device for image review is of adequate diagnostic quality based on image contrast, sharpness of structures, visible artefacts and overall display quality. Although reviewers were comfortable with using this technology, a handheld device with a larger screen may be diagnostically superior.
How the optical timing system, the longitudinal diagnostics and the associated feedback systems provide femtosecond stable operation at the FERMI free electron laser
Authors: Ferianis Mario , Allaria Enrico , Ferrari Eugenio , Gaio Giulio , Penco Giuseppe , Rossi Fabio , Veronese Marco 
Published: April 2016

FERMI, the seeded free electron laser (FEL) in operation in Italy, is providing the User Community with unique fully coherent radiation, in the wavelength range 100–4 nm. FERMI is the first FEL fully synchronized by means of optical fibers. The optical timing system ensures an ultra-stable phase reference to its distributed clients. Several femtosecond longitudinal diagnostics verify the achieved performance; the bunch length monitor (BLM) and the bunch arrival monitor (BAM) will be presented in this paper. Feedback systems play a crucial role to guarantee the needed long-term electron beam stability. A real-time infrastructure allows shot-to-shot communication between front-end computers and the servers. Orbit feedbacks are useful in machine tuning, whereas longitudinal feedbacks control electron energy, compression and arrival time. A flexible software framework allows a rapid implementation of heterogeneous multi-input–multi-output (MIMO) longitudinal loops simply by selecting the appropriate sensors and actuators.
A dissipative random velocity field for fully developed fluid turbulence
Authors: Pereira Rodrigo M. , Garban Christophe , Chevillard Laurent 
Published: April 2016

We investigate the statistical properties, based on numerical simulations and analytical calculations, of a recently proposed stochastic model for the velocity field (Chevillardet al.,Europhys. Lett., vol. 89, 2010, 54002) of an incompressible, homogeneous, isotropic and fully developed turbulent flow. A key step in the construction of this model is the introduction of some aspects of the vorticity stretching mechanism that governs the dynamics of fluid particles along their trajectories. An additional further phenomenological step aimed at including the long range correlated nature of turbulence makes this model dependent on a single free parameter,${\it\gamma}$, that can be estimated from experimental measurements. We confirm the realism of the model regarding the geometry of the velocity gradient tensor, the power-law behaviour of the moments of velocity increments (i.e. the structure functions) including the intermittent corrections and the existence of energy transfer across scales. We quantify the dependence of these basic properties of turbulent flows on the free parameter${\it\gamma}$and derive analytically the spectrum of exponents of the structure functions in a simplified non-dissipative case. A perturbative expansion in power of${\it\gamma}$shows that energy transfer, at leading order, indeed take place, justifying the dissipative nature of this random field.
Asymmetric breaking size-segregation waves in dense granular free-surface flows
Authors: Gajjar P. , van der Vaart K. , Thornton A. R. , Johnson C. G. , Ancey C. , Gray J. M. N. T. 
Published: April 2016

Debris and pyroclastic flows often have bouldery flow fronts, which act as a natural dam resisting further advance. Counter intuitively, these resistive fronts can lead to enhanced run-out, because they can be shouldered aside to form static levees that self-channelise the flow. At the heart of this behaviour is the inherent process of size segregation, with different sized particles readily separating into distinct vertical layers through a combination of kinetic sieving and squeeze expulsion. The result is an upward coarsening of the size distribution with the largest grains collecting at the top of the flow, where the flow velocity is greatest, allowing them to be preferentially transported to the front. Here, the large grains may be overrun, resegregated towards the surface and recirculated before being shouldered aside into lateral levees. A key element of this recirculation mechanism is the formation of a breaking size-segregation wave, which allows large particles that have been overrun to rise up into the faster moving parts of the flow as small particles are sheared over the top. Observations from experiments and discrete particle simulations in a moving-bed flume indicate that, whilst most large particles recirculate quickly at the front, a few recirculate very slowly through regions of many small particles at the rear. This behaviour is modelled in this paper using asymmetric segregation flux functions. Exact non-diffuse solutions are derived for the steady wave structure using the method of characteristics with a cubic segregation flux. Three different structures emerge, dependent on the degree of asymmetry and the non-convexity of the segregation flux function. In particular, a novel ‘lens-tail’ solution is found for segregation fluxes that have a large amount of non-convexity, with an additional expansion fan and compression wave forming a ‘tail’ upstream of the ‘lens’ region. Analysis of exact solutions for the particle motion shows that the large particle motion through the ‘lens-tail’ is fundamentally different to the classical ‘lens’ solutions. A few large particles starting near the bottom of the breaking wave pass through the ‘tail’, where they travel in a region of many small particles with a very small vertical velocity, and take significantly longer to recirculate.
Diversity of pseudo-toothed birds (Pelagornithidae) from the Eocene of Antarctica
Authors: Cenizo Marcos , Hospitaleche Carolina Acosta , Reguero Marcelo 
Published: April 2016

AbstractThe Antarctic pelagornithid record is restricted to few isolated remains from the Eocene of Seymour Island in the Antarctic Peninsula. Here we report the oldest Antarctic pseudo-toothed bird. It is represented by an incomplete humerus lacking its proximal end, which comes from the lower Eocene levels of the La Meseta Formation (Seymour Island). This new specimen facilitates a review of all known pelagornithids from this continent. Antarctic pelagornithids were classified into two morphotypes that exhibit a mix of putative plesiomorphic and derived characters. Considering the worldwide pelagornithid record and according to estimated wingspans, four approximate size-types were identified. The oldest Antarctic specimens (two fragmentary humeri, middle Ypresian) were assigned to morphotype 1 and correspond to the large size-type. The younger materials (Bartonian/?Priabonian) here assigned to morphotype 2 (some cranial remains, fragmentary tarsometatarsus and humerus) correspond to the giant size-type and represent one of the largest known pseudo-toothed birds. Even though species level phylogenetic affinities of Pelagornithidae remain poorly resolved, three key evolutionary events can be recognized: (1) the disappearance ofDasornisin the Early Eocene and the appearance of more advanced forms with a trend to the specialization of large soaring capacity, (2) the origin ofPelagornissensu lato species in the early Oligocene, and (3) the appearance and dominance of a highly specialized terminal group at Mio/Pliocene time span.
New Caledonian Triassic Bryozoa
Authors: Ernst Andrej , Schäfer Priska , Grant-Mackie Jack A. 
Published: April 2016

AbstractFour trepostome bryozoan species are described from the Upper Triassic of New Caledonia. They include one new genus Metastenodiscus n. gen. The studied fauna shows strong paleobiogeographic relations to New Zealand and less so to Japan. Morphological similarities between Middle Paleozoic and Triassic trepostome bryozoans (e.g., abundant diaphragms) are explained by homeomorphy.