bluuebunny/crossref_metadata_2025_split huggingface dataset:
Source and Size of Emotional and Financial-Related Social Support Network on Physical Activity Behavior Among Older Adults
Authors: Loprinzi Paul D. , Joyner Chelsea 
Published: February 2016

Objective:To examine the association of source of emotional- and financial-related social support and size of social support network on physical activity behavior among older adults.Methods:Data from the 1999–2006 NHANES were used (N = 5616; 60 to 85 yrs). Physical activity and emotional- and financial-related social support were assessed via self-report.Results:Older adults with perceived having emotional social support had a 41% increased odds of meeting physical activity guidelines (OR = 1.41; 95% CI: 1.01–1.97). The only specific sources of social support that were associated with meeting physical activity guidelines was friend emotional support (OR = 1.19; 95% CI: 1.01–1.41) and financial support (OR = 1.28; 95% CI: 1.09–1.49). With regard to size of social support network, a dose-response relationship was observed. Compared with those with 0 close friends, those with 1 to 2, 3 to 4, 5, and 6+ close friends, respectively, had a 1.70-, 2.38-, 2.57-, and 2.71-fold increased odds of meeting physical activity guidelines. There was some evidence of gender- and age-specific associations between social support and physical activity.Conclusions:Emotional- and financial-related social support and size of social support network are associated with higher odds of meeting physical activity guidelines among older adults.
Complete Genome Sequence of a Porcine Epidemic Diarrhea Virus Strain from Vietnam, HUA-14PED96, with a Large Genomic Deletion
Authors: Choe Se-Eun , Park Kee-Hwan , Lim Seong-In , Le Van Phan , Hien Nguyen Ba , Thach Pham Ngoc , Phuong Le Huynh Thanh , An Byung-Hyun , Han Song Hee , Cho In-Soo , An Dong-Jun 
Published: February 2016

ABSTRACT
A highly virulent strain of Porcine epidemic diarrhea virus (PEDV) causing severe diarrhea has recently emerged in Vietnam. Genomic sequences from a novel strain, HUA-14PED96, isolated from a Vietnamese piglet with serious diarrhea show relatively high identity with U.S.-like PEDV strains, and have a 72-nt deletion in the open reading frame 1a (ORF1a) gene.
Draft Genome Sequences of Two
Pseudoalteromonas
Strains Isolated from Roots and Leaf Blades of the Seagrass
Zostera marina
Authors: Alexiev Alexandra , Krusor Megan L. , Jospin Guillaume , Lang Jenna M. , Eisen Jonathan A. , Coil David A. 
Published: February 2016

ABSTRACT

Here, we present the draft genome sequences for
Pseudoalteromonas
sp. strain UCD-33C and
Pseudoalteromonas lipolytica
UCD-48B.
Pseudoalteromonas
sp. UCD-33C was isolated from
Zostera marina
roots and
P. lipolytica
UCD-48B from
Z. marina
leaf blades, both collected in Woods Hole, MA. These assemblies contain 4,479,285 bp and 4,592,435 bp, respectively.
Genome Sequences of
Streptomyces
Phages Amela and Verse
Authors: Layton Sonya R. , Hemenway Ryan M. , Munyoki Christine M. , Barnes Emory B. , Barnett Sierra E. , Bond Alec M. , Narvaez Jessi M. , Sirisakd Christie D. , Smith Brandt R. , Swain Justin , Syed Orooj , Bowman Charles A. , Russell Daniel A. , Bhuiyan Swapan , Donegan-Quick Richard , Benjamin Robert C. , Hughes Lee E. 
Published: February 2016

ABSTRACT

Amela and Verse are two
Streptomyces
phages isolated by enrichment on
Streptomyces venezuelae
(ATCC 10712) from two different soil samples. Amela has a genome length of 49,452, with 75 genes. Verse has a genome length of 49,483, with 75 genes. Both belong to the BD3 subcluster of Actinobacteriophage.
Draft Genome Sequence of Paenibacillus etheri sp. nov. SH7
T
, a Methyl Tert-Butyl Ether Degrader
Authors: Purswani Jessica , Guisado Isabel M. , Gonzalez-Lopez Jesus , Pozo Clementina 
Published: February 2016

ABSTRACT

We report here the draft genome sequence of
Paenibacillus etheri
sp. nov. SH7
T
(= CECT 8558
T
= DSM 29760
T
), isolated from a hydrocarbon-contaminated soil pilot plant in Granada, Spain. The bacterium was isolated and sequenced due to its methyl tert-butyl ether (MTBE)-degrading properties.
Draft Genome Sequence of Aspergillus niger Strain An76
Authors: Gong Weili , Cheng Zhi , Zhang Huaiqiang , Liu Lin , Gao Peiji , Wang Lushan 
Published: February 2016

ABSTRACT

The filamentous fungus
Aspergillus niger
has become one of the most important fungi in industrial biotechnology, and it can efficiently secrete both polysaccharide-degrading enzymes and organic acids. We report here the 6,074,961,332-bp draft sequence of
A. niger
strain An76, and the findings provide important information related to its lignocellulose-degrading ability.
Complete Chloroplast Genome Sequence and Annotation of the Tropical
japonica
Group of Asian Cultivated Rice (Oryza sativa L.)
Authors: Wang Shuo , Gao Li-zhi 
Published: February 2016

ABSTRACT

We announce here the first complete chloroplast genome sequence of the tropical
japonica
rice, along with its genome structure and functional annotation. The plant was collected from Indonesia and deposited as a germplasm accession of the International Rice GenBank Collection (IRGC 66630) at the International Rice Research Institute (IRRI). This genome provides valuable data for the future utilization of the germplasm of rice.
Draft Genome Sequences of Two Novel Amoeba-Resistant Intranuclear Bacteria, “
Candidatus
Berkiella cookevillensis” and “
Candidatus
Berkiella aquae”
Authors: Mehari Yohannes T. , Arivett Brock A. , Farone Anthony L. , Gunderson John H. , Farone Mary B. 
Published: February 2016

ABSTRACT

“
Candidatus
Berkiella cookevillensis” and “
Candidatus
Berkiella aquae” are obligate intranuclear endosymbionts of freshwater amoebae. Here, we present the draft genome sequences of these two bacteria, with total sizes of 2,990,361 bp and 3,626,027 bp, respectively.
Complete Genome Sequence of Multidrug-Resistant Citrobacter freundii Strain P10159, Isolated from Urine Samples from a Patient with Esophageal Carcinoma
Authors: Liu Xiaodong , Huang Yong , Xu Xiaomeng , Zhao Yachao , Sun Qiang , Zhang Zhiyi , Zhang Xianglilan , Wu Yi , Wang Jie , Zhou Dongsheng , An Xiaoping , Pei Guangqian , Wang Yunfei , Mi Zhiqiang , Yin Zhe , Tong Yigang 
Published: February 2016

ABSTRACT

Citrobacter freundii
is an opportunistic pathogen that can cause diarrhea, septicemia, meningitis, and urinary tract infections. We report here the complete genome sequence of
C. freundii
strain P10159, isolated from urine samples from a patient in China with esophageal carcinoma. The genome has 5,080,321 bp and 4,768 coding sequences, with a G+C content of 51.7%.
Draft Genome Sequence of Mycobacterium tuberculosis KT-0184, Isolated in South Korea
Authors: Kwon Taesoo , Han Seung Jung , Yoo Won Gi , Yun Mi-ran , Lee Sanghyun , Lee Jong Seok , Kim Dae-Won 
Published: February 2016

ABSTRACT

Here, we describe the draft genome sequence of
Mycobacterium tuberculosis
KT-0184, from the Beijing family. This genome will provide insight into the evolution and adaptation of
M. tuberculosis
KT-0184 in human hosts.
First Complete Genome Sequence of Tenacibaculum dicentrarchi, an Emerging Bacterial Pathogen of Salmonids
Authors: Grothusen Horst , Castillo Alejandro , Henríquez Patricio , Navas Esteban , Bohle Harry , Araya Carolina , Bustamante Fernando , Bustos Patricio , Mancilla Marcos 
Published: February 2016

ABSTRACT

Tenacibaculum
-like bacilli have recently been isolated from diseased sea-reared Atlantic salmon in outbreaks that took place in the XI region (Región de Aysén) of Chile. Molecular typing identified the bacterium as
Tenacibaculum dicentrarchi
. Here, we report the complete genome sequence of the AY7486TD isolate recovered during those outbreaks.
Complete Genome Sequence of Pseudomonas aeruginosa Phage-Resistant Variant PA1RG
Authors: Li Gang , Lu Shuguang , Shen Mengyu , Le Shuai , Tan Yinling , Li Ming , Zhao Xia , Wang Jing , Shen Wei , Guo Keke , Yang Yuhui , Zhu Hongbin , Li Shu , Zhu Junmin , Rao Xiancai , Hu Fuquan 
Published: February 2016

ABSTRACT

Bacteria have evolved several defense systems against phage predation. Here, we report the 6,500,439-bp complete genome sequence of the
Pseudomonas aeruginosa
phage-resistant variant PA1RG. Single-molecule real-time (SMRT) sequencing and
de novo
assembly revealed a single contig with 320-fold sequence coverage.
Draft Genome Sequence of Flavobacterium psychrophilum Strain KTEN-1510 with Genotype A/G-C, Isolated from an Ayu (Plecoglossus altivelis altivelis ) in the Kagami River, Kochi, Japan
Authors: Shimizu Masato , Goda Hikaru , Yamasaki Kenichi , Oshima Syun-ichirou , Ohnishi Kouhei , Osaki Yasuo , Kataoka Shigehiko , Imajoh Masayuki 
Published: February 2016

ABSTRACT

In this paper, we describe the draft genome sequence of
Flavobacterium psychrophilum
strain KTEN-1510, with genotype A/G-C. This strain was isolated in October 2015 from the gills of an ayu (
Plecoglossus altivelis altivelis
) in the upper Kagami River in central Kochi Prefecture on Shikoku Island, Japan.
Draft Genome Sequences of Two Vibrio splendidus Strains, Isolated from Seagrass Sediment
Authors: Lee Ruth D. , Jospin Guillaume , Lang Jenna M. , Eisen Jonathan A. , Coil David A. 
Published: February 2016

ABSTRACT

Here, we present the draft genome sequences of
Vibrio splendidus
UCD-SED7 and UCD-SED10 (phylum
Proteobacteria
). These strains were isolated from sediment surrounding
Zostera marina
roots near the UC Davis Bodega Marine Laboratory (Bodega, Bay, California). These assemblies contain 5,334,236 bp and 5,904,824 bp, respectively.
Association between sleep disorders and injury: a nationwide population-based retrospective cohort study
Authors: Lin Chia-Ling , Chung Chi-Hsiang , Tsai Yu-Hsia , Chien Wu-Chien 
Published: February 2016

BackgroundThe evidence is insufficient for the association between the exposure of sleep disorders and the risk of injury. The aim of this study was to examine the association between patients with sleep disorders and the risk of injury.MethodsThis was a population-based retrospective cohort study using Taiwan National Health Insurance Research Database from 2005 to 2010. A total of 15 109 patients with sleep disorders were identified as the study cohort. The non-sleep disorders control cohort comprised 29 955 age- and sex-matched patients. We conducted a Cox proportional hazard regression analysis to estimate the effects of sleep disorders on the risk of injury.ResultsThe overall incidence of injury was 77.03 per 1000 person-years for patients with sleep disorders, which was significantly higher than that of the control cohort (60.63 per 1000 person-years). Overall, patients with sleep disorders had a higher risk of injury compared with control cohort (adjusted HR=1.27, 95% CI 1.26 to 1.28). Comparing to the control cohort, patients with insomnia had a 12% higher risk for injury (adjusted HR, 1.12 (95% CI 1.01 to 1.41)).ConclusionsComparing to patients with non-sleep disorders, patients with sleep disorders had a higher risk of injury and the risk was particularly pronounced in those who had insomnia.
Illustrations reduce contamination of midstream urine samples in the emergency department
Authors: Eley Robert , Judge Chantelle , Knight Lisette , Dimeski Goce , Sinnott Michael 
Published: February 2016

AimsUrinalysis provides direction in diagnosis and treatment of patients in the emergency department (ED). Midstream urine (MSU) collection from female patients has a high contamination rate. Verbal instruction by nurses to patients reduces contamination but is inconsistent owing to lack of time and professional knowledge. This study aimed to determine if an alternative mode of instruction requiring minimal staff input may be effective.MethodsA pseudorandomised controlled trial was undertaken with 240 female patients for whom urinalysis was clinically required. No change was made to normal practice with regards to verbal instruction. Prior to collecting their sample the intervention cohort received illustrated instruction on how to collect a clean uncontaminated MSU sample. The control cohort received no illustrated instruction. Compared outcomes were rate of contamination on urinalysis, defined as 10 or more epithelial cells per high power field, and answers to a structured patient questionnaire.ResultsContamination rate was reduced from 40% to 25% by the intervention. According to patient survey responses, verbal collection instructions were seldom given and the actions of hand washing, cleaning with a towelette, and voiding then stopping were significantly higher in the intervention group. The illustrations were well received by over 95% of patients and were considered to be clear and effective especially for patients with reading difficulties and/or from a non-English speaking background.ConclusionsIllustrated urine collection instructions were well accepted by female ED patients, improved the rate of proper MSU collection and reduced the rate of urinalysis contamination in the ED.
Adalimumab discontinuation in patients with early rheumatoid arthritis who were initially treated with methotrexate alone or in combination with adalimumab: 1 year outcomes of the HOPEFUL-2 study
Authors: Tanaka Yoshiya , Yamanaka Hisashi , Ishiguro Naoki , Miyasaka Nobuyuki , Kawana Katsuyoshi , Hiramatsu Katsutoshi , Takeuchi Tsutomu 
Published: February 2016

ObjectivesTo evaluate the impact of discontinuation of adalimumab (ADA) for 1 year in Japanese patients with early rheumatoid arthritis (RA).MethodsThis 52-week postmarketing study, HOPEFUL-2, enrolled patients who had completed HOPEFUL-1 for early RA, in which patients received either ADA + methotrexate (MTX) or MTX alone in a 26-week randomised phase, followed by ADA+MTX in a 26-week open-label phase.ResultsA total of 220 patients (ADA discontinuation: 114 patients vs ADA continuation: 106 patients) were enrolled in this study. The proportion of patients with sustained low disease activity (LDA) in the ADA discontinuation group was significantly lower than that in the continuation group (80% (64/80 patients) vs 97% (71/73 patients); p=0.001); however, most patients sustained LDA in both groups. In patients with 28-joint disease activity score (DAS28)-C reactive protein ≤2.0 at week 52, the proportion of patients who achieved sustained LDA at week 104 was 93%, suggesting that DAS28 remission may be a predictor to indicate biological-free disease control in patients with early RA. The incidence of adverse events (AE) was significantly lower in the ADA discontinuation group than in the continuation group (34.2% (39/114 patients) vs 48.1% (51/106 patients); p=0.04), most notably for infection (14.9% vs 27.4%, p=0.031).ConclusionsAlthough ADA discontinuation was associated with an increase in disease activity, a large proportion of patients maintained LDA with MTX monotherapy after ADA discontinuation. Since ADA discontinuation was associated with a lower AE incidence, physicians should weigh the risks and benefits of ADA discontinuation.Trial registration numberNCT01163292.
The local structure of skutterudites: A view from inside the unit cell
Authors: Bridges Frank 
Published: February 2016

The skutterudites form a large class of compounds with many unusual properties, attributed in part to the novel crystal structure. The unit cell is cubic and is composed of eight sub-cubes formed by transition metal atoms. Six of the sub-cubes contain rings of atoms; the other two sub-cubes can be empty but are usually filled with rare earth or alkali earth atoms. These “filler” atoms can vibrate at low energies and hence are called “rattler” atoms. Here, the dynamics of various atom pairs are reviewed with a focus on the rattler atoms. Most of the work is based on extended X-ray absorption fine structure (EXAFS) studies but results obtained using other techniques, such as inelastic scattering experiments or atomic displacement parameters in diffraction, are also included. Although the main framework of the unit cell is often considered quite stiff, the stiffest springs in the system are only factors of 3–5 larger than the springs connecting the rattler to its neighbors. In addition, the environment about the atoms in the ring structures (e.g. Sb4 in CeFe4Sb[Formula: see text]) has a low symmetry and our recent EXAFS experiments suggest that the rings can be considered to be quasi-rigid units, and treated as a large atom. The restoring forces on the rings are asymmetric, with large forces perpendicular to the ring and weak forces in the direction toward a rattler. This suggests that some low energy modes that have been observed in these systems may be a correlated motion of the rattler atoms and the rings. In addition, the unusual result that the second neighbor effective spring constants are stiffer than the nearest neighbor bonds has been observed for several oxy-skutterudites. A simple one-dimensional (1D) model, of a chain of rattlers and rings, weakly coupled to the rest of the lattice has been developed which can explain these unusual results. These calculations also indicate that the thermal conductivity might be further suppressed using a composite formed of several types of nanoparticles rather than just multiple filling on the rattler sites.
Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes
Authors: Markowitz Geoffrey J. , Yang Pengyuan , Fu Jing , Michelotti Gregory A. , Chen Rui , Sui Jianhua , Yang Bin , Qin Wen-Hao , Zhang Zheng , Wang Fu-Sheng , Diehl Anna Mae , Li Qi-Jing , Wang Hongyang , Wang Xiao-Fan 
Published: February 2016

AbstractChronic inflammation in liver tissue is an underlying cause of hepatocellular carcinoma. High levels of inflammatory cytokine IL18 in the circulation of patients with hepatocellular carcinoma correlates with poor prognosis. However, conflicting results have been reported for IL18 in hepatocellular carcinoma development and progression. In this study, we used tissue specimens from hepatocellular carcinoma patients and clinically relevant mouse models of hepatocellular carcinoma to evaluate IL18 expression and function. In a mouse model of liver fibrosis that recapitulates a tumor-promoting microenvironment, global deletion of the IL18 receptor IL18R1 enhanced tumor growth and burden. Similarly, in a carcinogen-induced model of liver tumorigenesis, IL18R1 deletion increased tumor burden. Mechanistically, we found that IL18 exerted inflammation-dependent tumor-suppressive effects largely by promoting the differentiation, activity, and survival of tumor-infiltrating T cells. Finally, differences in the expression of IL18 in tumor tissue versus nontumor tissue were more predictive of patient outcome than overall tissue expression. Taken together, our findings resolve a long-standing contradiction regarding a tumor-suppressive role for IL18 in established hepatocellular carcinoma and provide a mechanistic explanation for the complex relationship between its expression pattern and hepatocellular carcinoma prognosis. Cancer Res; 76(8); 2394–405. ©2016 AACR.
In VivoVisualization and Characterization of Epithelial–Mesenchymal Transition in Breast Tumors
Authors: Zhao Zhen , Zhu Xiaoping , Cui Kemi , Mancuso James , Federley Richard , Fischer Kari , Teng Gao-jun , Mittal Vivek , Gao Dingcheng , Zhao Hong , Wong Stephen T.C. 
Published: February 2016

AbstractThe activation of the epithelial-to-mesenchymal transition (EMT) program is a critical step in cancer progression and metastasis, but visualization of this process at the single-cell level, especially in vivo, remains challenging. We established an in vivo approach to track the fate of tumor cells based on a novel EMT-driven fluorescent color switching breast cancer mouse model and intravital two-photon laser scanning microscopy. Specifically, the MMTV-PyMT, Rosa26-RFP-GFP, and Fsp1-Cre triple transgenic mouse model was used to monitor the conversion of RFP-positive epithelial cells to GFP-positive mesenchymal cells in mammary tumors under the control of the Fsp1 (ATL1) promoter, a gate-keeper of EMT initiation. RFP-positive cells were isolated from the tumors, sorted, and transplanted into mammary fat pads of SCID mice to monitor EMT during breast tumor formation. We found that the conversion from RFP- to GFP-positive and spindle-shaped cells was a gradual process, and that GFP-positive cells preferentially localized close to blood vessels, independent of tumor size. Furthermore, cells undergoing EMT expressed high levels of the HGF receptor, c-Met, and treatment of RFP-positive cells with the c-Met inhibitor, cabozantinib, suppressed the RFP-to-GFP conversion in vitro. Moreover, administration of cabozantinib to mice with palpable RFP-positive tumors resulted in a silent EMT phenotype whereby GFP-positive cells exhibited reduced motility, leading to suppressed tumor growth. In conclusion, our imaging technique provides a novel opportunity for visualizing tumor EMT at the single-cell level and may help to reveal the intricacies underlying tumor dynamics and treatment responses. Cancer Res; 76(8); 2094–104. ©2016 AACR.
Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia
Authors: Turner Rosanne J. , Bloemenkamp Kitty W.M. , Bruijn Jan A. , Baelde Hans J. 
Published: February 2016

Objective—
Preeclampsia is a pregnancy-specific syndrome characterized by placental dysfunction and an angiogenic imbalance. Systemically, levels of thrombomodulin, an endothelium- and syncytiotrophoblast-bound protein that regulates coagulation, inflammation, apoptosis, and tissue remodeling, are increased. We aimed to investigate placental thrombomodulin dysregulation and consequent downstream effects in the pathogenesis of preeclampsia.

Approach and Results—

Placentas from 28 preeclampsia pregnancies, 30 uncomplicated pregnancies, and 21 pregnancies complicated by growth restriction as extra controls were included. Immunohistochemical staining of thrombomodulin, caspase-3, and fibrin was performed. Placental mRNA expression of thrombomodulin, inflammatory markers, matrix metalloproteinases 2 and 9, and soluble Flt-1 were measured with quantitative polymerase chain reaction. Thrombomodulin mRNA expression was determined in vascular endothelial growth factor–transfected trophoblast cell lines. Thrombomodulin protein and mRNA expression were decreased in preeclampsia as compared with both control groups (
P
=0.001). Thrombomodulin mRNA expression correlated with maternal body mass index (
P
<0.01) and diastolic blood pressure (
P
<0.05) in preeclampsia. An increase in placental apoptotic cells was associated with preeclampsia (
P
<0.001). Thrombomodulin expression correlated positively with matrix metalloproteinase expression (
P
<0.01) in preeclampsia, but not with fibrin deposits or inflammatory markers. Placental soluble Flt-1 expression correlated with decreased thrombomodulin expression. Vascular endothelial growth factor induced upregulation of thrombomodulin expression in trophoblast cells.

Conclusions—
Decreased thrombomodulin expression in preeclampsia may play a role in placental dysfunction in preeclampsia and is possibly caused by an angiogenic imbalance. Hypertension and obesity are associated with thrombomodulin downregulation. These results set the stage for further basic and clinical research on thrombomodulin in the pathogenesis of preeclampsia and other syndromes characterized by endothelial dysfunction.