bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized Medicine: The Future of Health Care
Authors: Meiliana Anna , Dewi Nurrani Mustika , Wijaya Andi 
Published: December 2016

BACKGROUND: Most medical treatments have been designed for the “average patients”. As a result of this “one-size-fits-all-approach”, treatments can be very successful for some patients but not for others. The issue is shifting by the new innovation approach in diseases treatment and prevention, precision medicine, which takes into account individual differences in people’s genes, environments, and lifestyles. This review was aimed to describe a new approach of healthcare performance strategy based on individual genetic variants.CONTENT: Researchers have discovered hundreds of genes that harbor variations contributing to human illness, identified genetic variability in patients’ responses to different of treatments, and from there begun to target the genes as molecular causes of diseases. In addition, scientists are developing and using diagnostic tests based on genetics or other molecular mechanisms to better predict patients’ responses to targeted therapy.SUMMARY: Personalized medicine seeks to use advances in knowledge about genetic factors and biological mechanisms of disease coupled with unique considerations of an individual’s patient care needs to make health care more safe and effective. As a result of these contributions to improvement in the quality of care, personalized medicine represents a key strategy of healthcare reform.KEYWORDS: precision medicine, genomic, proteomic, metabolomic
Os relevos da memória
Authors: Santa Cruz Lucia 
Published: December 2016

Este artigo aborda projetos memorialísticos desenvolvidos por meios de comunicação. Iniciativas como Memória Globo, Memória O Globo, Acervo Estadão, se mostram, simultaneamente, movimentos de valorização da memória e instrumentos de produção de novas versões sobre fatos passados, envolvendo ou não os veículos jornalísticos. Além de funcionarem como resgate e preservação da história dos veículos, reforçando ou estabelecendo uma determinada identidade, são o que Pierre Nora chamou de “lugares de memória” - espaços físicos ou não onde indivíduos e grupos sociais podem ancorar sua memória, face ao fenômeno da aceleração da história que torna o presente cada vez mais volátil. Ao assumirem esta configuração, colocam em questão aspectos constituintes do jornalismo, tais como critérios de atualidade e novidade, além de fomentarem uma rediscussão dos valores de noticiabilidade.
Custos da ampliação da licença-paternidade no Brasil
Authors: Almeida Sergio , Pereda Paula , Ferreira Rafael 
Published: December 2016

Há uma crescente literatura empírica documentando que educação e cuidado parental de qualidade estão associados com um melhor desenvolvimento emocional e cognitivo da criança. Diante disso, governos de vários países vêm promovendo mudanças nas suas leis trabalhistas, com o objetivo de dar suporte financeiro e legal (proteção do emprego) para as mães e também os pais com crianças recém-nascidas. O Brasil aprovou recentemente o Marco Legal da Primeira Infância (Lei n. 13.257/2016), que ampliou a licença-paternidade de 5 para 20 dias. Pouco se sabe, entretanto, sobre o impacto econômico desse tipo de política pública. O presente trabalho procura quantificar os custos intertemporais do custo econômico direto da extensão da licença-paternidade para o Brasil. Para isso utilizam-se microdados da Pesquisa Nacional por Amostra de Domicílios, indicadores do mercado de trabalho brasileiro e uma série de projeções populacionais para construir cenários estáticos para estimativas da probabilidade de os pais solicitarem o uso da licença. Os resultados indicam que a extensão da licença-paternidade para 20 dias tem baixo custo – cerca de R$ 100 milhões por ano no cenário mais provável, o que representa 0,01% da arrecadação federal em 2014. Conquanto a magnitude dos benefícios seja ainda desconhecida no Brasil, os resultados sugerem que esse tipo de intervenção será provavelmente custo-efetiva.
Interrater Reliability and Age-Based Normative Values for Radiographic Indices of the Ankle Syndesmosis in Children
Authors: Lakomkin Nikita , Fabricant Peter D. , Cruz Aristides I. , Brusalis Christopher M. , Chauvin Nancy A. , Lawrence J. Todd R. 
Published: December 2016

Background:
While recent research has investigated the normative values, discriminative capacity, and interrater reliability of radiographic indices for the evaluation of the syndesmosis in adults, no such data exist for children. The purposes of the present study were (1) to determine the interrater reliability of common radiographic measures of syndesmosis and deltoid ligament competency in children and (2) to establish age-based normative values.

Methods:
A consecutive series of patient radiographs from a Level-I pediatric trauma center were identified and were used to create an age and sex-balanced cohort of 282 patients. Subjects between 2 and 17 years of age were randomly selected from a pool of patients who had a complete 3-view (anteroposterior, lateral, and mortise) radiographic ankle series and a final diagnosis without osseous or ligamentous injury. Eight age and sex-balanced groups were created for analysis. Three independent raters evaluated all radiographs and recorded radiographic indices that are commonly used for the evaluation of ankle trauma: width of medial clear space, width of superior clear space, tibiofibular clear space, tibiofibular overlap, and medial clear space/superior clear space ratio. Interrater reliability was calculated with use of the intraclass correlation coefficient (ICC); means and standard deviations were used to report age-group normative values.

Results:
Two hundred and eighty-two patients (mean age [and standard deviation], 9.6 ± 4.6 years) were analyzed. The superior clear space and tibiofibular overlap demonstrated excellent interrater reliability (ICC = 0.915 and 0.964, respectively), the medial clear space and tibiofibular clear space demonstrated substantial agreement (ICC = 0.656 and 0.635, respectively), and the medial clear space/superior clear space ratio demonstrated moderate agreement (ICC = 0.418). The medial clear space could not be reliably measured until the age of 8 years because of insufficient ossification of the medial malleolus. Tibiofibular overlap demonstrated a linear increase over time, ranging from −1.4 mm in 2 and 3-year-old patients to 6.7 mm in 16 and 17-year-old patients (R2 = 0.995). Normative values varied by age and sex.

Conclusions:
The medial clear space and medial clear space/superior clear space ratio could not be reliably assessed for children under 8 years of age and were thus characterized by suboptimal interrater reliability. Tibiofibular overlap had excellent interrater agreement, changed predictably with skeletal growth, and may be useful for future research as well as the clinical assessment of pediatric ankle injuries to guide clinical decision-making.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
POTENCIAIS SEQUÊNCIAS DE APRENDIZAGEM INTERCULTURAL NO TELETANDEM: A IMPORTÂNCIA DA MEDIAÇÃO
Authors: Freschi Ana Carolina , Lopes Queila Barbosa 
Published: December 2016

A partir da caracterização do teletandem como Terceiro Espaço, onde o contato intercultural tem território privilegiado (KRAMSCH; URYU, 2014), e dos conceitos de competência intercultural (BELZ, 2003) e paráfrases (ORLANDI, 1987; 2000; PECHÊUX, 1997), discutimos a relevância da identificação de potenciais sequências de aprendizagem intercultural (BORGHETTI et al, 2015) como oportunidades para melhor autocompreensão e autocrítica e desenvolvimento da competência intercultural a partir da mediação realizada no teletandem. Assim, nosso artigo situa-se na interface entre estudos linguísticos, estudos culturais e análise do discurso de linha francesa. Os dados analisados foram coletados em 2011, 2012 e 2014 e tiveram como temas: preconceito linguístico e regional, eleições presidenciais, copa do mundo de futebol no Brasil e generalizações quanto a situação das escolas no Estado de São Paulo. Esses assuntos embasaram parte das interações e suscitaram diversas paráfrases que nos levaram aos questionamentos apresentados. Por meio da análise de quatro sessões de teletandem de pares diferentes, pudemos identificar potenciais sequências de aprendizagem intercultural, o que demonstra o potencial do teletandem como espaço desse tipo de aprendizagem. As sessões de mediação podem contribuir significativamente para o desenvolvimento dessa competência, auxiliando a compreender as identidades e o que entendemos ser a identidade que afirmamos ter.
Impacto da saúde bucal na qualidade de vida de adolescentes grávidas
Authors: Lima Daniela Pereira , Moimaz Suzely Adas Saliba , Garbin Cléa Adas Saliba , Sundefeld Maria Lúcia Marçal Mazza , Rovida Tânia Adas Saliba 
Published: December 2016

Objetivo: avaliar o impacto da saúde bucal na qualidade de vida de adolescentes grávidas e identificar os fatores sócio-demográficos que podem influenciar nesse conceito. Material e método: estudo transversal tipo inquérito e levantamento das condições de saúde bucal de 127 adolescentes grávidas. Para mensurar o impacto da saúde bucal na qualidade de vida foi utilizado o OHIP-14, aplicado com um questionário sócio-demográfico. As condições de saúde bucal foram analisadas, empregando-se os Índices CPO-D, SiC-Index, e IPC de acordo com os critérios estabelecidos pela OMS. Foram realizadas análises estatísticas descritivas, e o teste Exato de Fisher com nível de significância de 5%. Resultados: Não houve adolescentes nas classes sociais A1 e A2. A grande maioria 79,5% relatou impacto das condições bucais em sua qualidade de vida. O item que demonstrou maior impacto foi a dor física, manifestada por 23,6% das participantes. O índice CPO-D foi 12,51 (dp = 4,21) e o SiC Index foi de 18,85. O percentual de livres de cárie foi 6,3% e 91,3% apresentavam problemas periodontais. Houve associação estatística significante entre as variáveis: impacto na qualidade de vida e doença periodontal (p= 0,0311). Conclusão: Por se tratar de um estudo realizado em Unidades Básicas de Saúde não houve gestantes nos níveis sociais mais elevados. As adolescentes apresentaram alto índice de cárie dentária e doença periodontal, revelando saúde bucal deficiente. A maioria relatou impacto na qualidade de vida em decorrência de problemas bucais, sendo a presença de “dor física” a maior responsável pelas repercussões negativas na vida destas meninas.Descritores: Saúde Bucal; Qualidade de Vida; Adolescente; Gravidez.
Matrix-assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry (MALDI-TOF MS) as a Reliable Tool to Identify Species of Catalase-negative Gram-positive Cocci not Belonging to the Streptococcus Genus
Authors: Almuzara Marisa , Barberis Claudia , Velázquez Viviana Rojas , Ramirez Maria Soledad , Famiglietti Angela , Vay Carlos 
Published: December 2016

Objective:To evaluate the performance of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) by using 190 Catalase-negative Gram-Positive Cocci (GPC) clinical isolates.Methods:All isolates were identified by conventional phenotypic tests following the proposed scheme by Ruoff and Christensen and MALDI-TOF MS (Bruker Daltonics, BD, Bremen, Germany). Two different extraction methods (direct transfer formic acid method on spot and ethanol formic acid extraction method) and different cut-offs for genus/specie level identification were used. The score cut-offs recommended by the manufacturer (≥ 2.000 for species-level, 1.700 to 1.999 for genus level and <1.700 no reliable identification) and lower cut-off scores (≥1.500 for genus level, ≥ 1.700 for species-level and score <1.500 no reliable identification) were considered for identification. A minimum difference of 10% between the top and next closest score was required for a different genus or species.MALDI-TOF MS identification was considered correct when the result obtained from MS database agreed with the phenotypic identification result.When both methods gave discordant results, the 16S rDNA orsodAgenes sequencing was considered as the gold standard identification method. The results obtained by MS concordant with genes sequencing, although discordant with conventional phenotyping, were considered correct. MS results discordant with 16S orsodA identification were considered incorrect.Results:Using the score cut-offs recommended by the manufacturer, 97.37% and 81.05% were correctly identified to genus and species level, respectively. On the other hand, using lower cut-off scores for identification, 97.89% and 94.21% isolates were correctly identified to genus and species level respectively by MALDI-TOF MS and no significant differences between the results obtained with two extraction methods were obtained.Conclusion:The results obtained suggest that MALDI-TOF MS has the potential of being an accurate tool for Catalase-negative GPC identification even for those species with difficult diagnosis asHelcococcus,Abiotrophia,Granulicatella, among others. Nevertheless, expansion of the library, especially including more strains with different spectra on the same species might overcome potential “intraspecies” variability problems. Moreover, a decrease of the identification scores for species and genus-level identification must be considered since it may improve the MALDI-TOF MS accuracy.
Pervious Concrete: Mix Design, Properties and Applications
Authors: Sonebi Mohammed , Bassuoni Mohamed , Yahia Ammar 
Published: December 2016

Current climatic changes are occurring due to various human and industrial activities. In particular, the effects of urbanisation and growing threat of global warming have likely caused increasing precipitation in many geographic regions. For many years, portland cement pervious concrete (PCPC) has been making an important contribution, as a sustainable urban drainage system (SUDS), on improving environmental conditions. This type of porous concrete can help minimizing flooding risks, recharging ground water, reducing run off and peak flows, alleviating the precipitation load on overstressed drainage systems and improving water quality by capturing pollutants. The benefits of using PCPC in order to attenuate stormwater problems are quite essential mainly in urban areas where most surfaces typically consist of relatively impervious concrete or asphalt pavements, causing elevated levels of surface runoff. In addition, PCPC can reduce the absorption of solar radiation and urban heat storage potential which can lead to temperate urban conditions, and thus protecting the environment and health and safety of living things. However, PCPC requires regular maintenance to prevent any clogging of the pores by sediments and vegetation. This article provides an overview on pervious concrete mix design, key properties, durability and applications. Also, it touches on practical and scientific challenges of PCPC.
INFORMATION AND KNOWLEDGE OF PUBLIC SECTOR DECISION MAKERS: EXPERIMENTAL RESEARCH IN THE CONTEXT OF A LOCAL GOVERNMENT HOSPITAL IN INDONESIA
Authors: Bawono Icuk Rangga , Halim Abdul , Lord Beverley R. 
Published: December 2016

This research aimed to test the previous result of experimental research on decision making by Dilla and Steinbart (2005), and to internalize the result in the context of a local government hospital in Indonesia. The subjects in this experiment were 80 members of the House of Representatives in the Cilacap, Brebes and Purbalingga regions in Indonesia. They were asked to evaluate the performance of a fictitious local government hospital and decide whether or notto increase its budget allocation for the coming year. Half of the subjects were given instruction in the performance measures applicable to hospitals; the other half proceeded straight to the experimental task. The first group were labelled “knowledgeable users”; the latter group were classified as “unknowledgeable”.The results of this experiment using real decision makers showed that the knowledgeable group tended to use the unique information given to them to measure performance and make budget allocation plans, whereas the unknowledgeable group used common measures. These results are consistent with Lipe and Salterio (2000), Dilla and Steinbart (2005) and Bawono etal. (2012), indicating that students may be reliable surrogates for real decision makers.Keywords: accountability, public sector, performance measurement, budget allocation plan, knowledgeable and unknowledgeable, decision makers
Perawatan Ortodontik Alat Lepasan Kombinasi Semi-Cekat pada Kehilangan Gigi 46
Authors: Ditaprilia Maharetta , Ardhana Wayan , Christnawati Christnawati 
Published: December 2016

Salah satu pertimbangan dalam menentukan alat ortodontik yang akan digunakan adalah biaya. Alat ortodontik lepasan dipilih karena memerlukan biaya yang lebih rendah dibanding dengan alat ortodontik cekat. Perawatan ortodontik dengan alat lepasan sulit dilakukan jika disertai dengan pencabutan satu atau beberapa gigi posterior. Pasien perempuan usia 23 tahun, mengeluhkan gigi rahang atas maju dan gigi rahang bawah berjejal. Pemeriksaan objektif menunjukkan protrusif rahang atas, crowding rahang bawah, palatal bite, disertai kehilangan gigi 46. Maloklusi Angle Kelas II divisi 1 tipe dentoskeletal, hubungan skeletal klas II, protrusif bimaksilar, bidental protrusif, overjet 7,2 mm, crowding, palatal bite, dan kebiasaan bernafas melalui mulut. Perawatan menggunakan kombinasi alat semi-cekat pada rahang bawah dan alat lepasan pada rahang atas. Alat semi-cekat digunakan untuk space clossing bekas pencabutan gigi 46. Terjadi space closing bekas pencabutan gigi 46 setelah 6 bulan perawatan. Overjet berkurang menjadi 4 mm dan overbite 2,7 mm setelah 1 tahun perawatan. Kombinasi alat semi-cekat pada rahang bawah dan alat ortodontik lepasan pada rahang atas efektif untuk koreksi maloklusi Angle Klas II divisi 1 dengan kehilangan gigi 46 pada pasien ini. ABSTRACT: Orthodontic Treatment Using Semi-Fixed Appliances with Partial Edentulous 46. Cost is one of the considerations in determining the use of orthodontic appliances. Removable orthodontic appliance is chosen because it is less costly than fixed orthodontic appliances. It is difficult to use removable orthodontic appliances to treat a missing one or more posterior teeth case. A 23 year old female patient had a chief complaint of crowding in lower anterior teeth and forwardly placed upper anterior teeth. Her objective examination shows protrution of upper teeth, crowding in the lower arch, palatal bite, and partial edentulous of 46 tooth. It was Angle Class II division 1 dentoskeletal malocclusion, skeletal class II, bimaxillary protrusion, bidental protrusion, overjet 7,2 mm, crowding, palatal bite, and mouth-breathing habit. The treatment used a combination of semi-fixed orthodontic appliances in the lower arch and removable appliances in the upper arch. The semi-fixed orthodontic appliances were used on space closing of partial edentulous 46. The partial edentulous 46 was closed after 6 months of treatment. The overjet was reduced to 4 mm and overbite 2,7 mm after one year of treatment. The combination of semi-fixed orthodontic appliances in the lower arch and removable appliances in the upper arch generate a good result to correct Angle Class II division 1 malocclusion with partial edentulous 46.
Penatalaksanaan Miksoma Odontogenik Periferal Maksila Sinistra pada Penderita Geriatri Pasca Stroke Non Hemoragik dengan Anestesi Umum
Authors: Khoiriyah Anik , Widastuti Maria Goreti , Hasan Cahya Yustisia 
Published: December 2016

Miksoma odontogenik tipe periferal adalah miksoma yang berlokasi pada jaringan lunak, tumbuh lambat, kurang agresif dan mempunyai tingkat rekurensi yang rendah dibandingkan dengan miksoma odontogenik tipe sentral. Miksoma odontogenik periferal bisa terjadi pada setiap dekade kehidupan, paling banyak terjadi pada dekade keempat. Tujuan penulisan studi kasus ini adalah melaporkan keberhasilan eksisi miksoma odontogenik periferal yang terjadi pada pasien geriatri pasca stroke non hemoragik. Seorang pasien wanita usia 74 tahun, terdapat benjolan di gingiva rahang atas kiri, timbul sejak 3 bulan yang lalu, tidak sakit, tidak mudah berdarah, tetapi mengganggu pengunyahan. Pasien memiliki riwayat stroke non hemoragik yang terkontrol. Eksisi lesi dan kuretase tulang dilakukan dengan anestesi umum. Hasil pasca operasi, setelah dilakukan follow-up selama 6 bulan, tidak ada keluhan pasien terkait dengan penyakit yang diderita, tidak dehisensi, tidak kambuh dan prognosis baik. Eksisi miksoma odontogenik periferal yang terjadi pada pasien geriatri pasca stroke non hemoragik bisa dilakukan, tetapi harus dengan persiapan perioperatif yang optimal, meliputi konsultasi ke bagian neurologi, kardiologi dan rawat bersama dengan bagian penyakit dalam sub bagian geriatri, untuk meminimalkan interaksi obat-obatan yang diberikan dan mencegah komplikasi pasca operasi. ABSTRACT: Excision Peripheral Odontogenic Myxoma of the Maxillary Sinistra on Post Stroke Non-Hemorrhagic Patients under General Anesthesia. Peripheral odontogenic myxoma is a myxoma located on soft tissue, growing slowly, less aggressive and owning low recurrency rate compared to central odontogenic myxoma. Peripheral odontogenic myxoma may occur in every decade of life, mostly in the fourth decade. The aim of this report is to expose the successful excision of peripheral odontogenic myxoma on post non-hemorrhagic stroke of geriatric patient. A seventy-four-year-old woman had a pedunculated mass on the left maxillary gingivitis. It had been growing for 3 months, non-tender, non-bleeding but causing chewing inconvenience. She had a controlled non-hemorrhage stroke. An excision of lesion and bone curettage was conducted under general anesthesia. Six months after the operation, the follow-up showed no further complaints concerning her disease, no dehiscence, no recurrence, and the prognosis was good. It can be concluded that the excision of peripheral odontogenic myxoma on post non-hemorrhagic stroke of geriatric patients was feasible. However, it must be conducted under adequate perioperative preparation, which consists of neurology and cardiology consultation and joint treatment between internal department and geriatric sub-department to minimize drug interaction and to prevent post-operative complication.