bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling strategies for enhancing educational quality
Authors: Cummings William K , Bain Olga 
Published: June 2017

With the strengthening of the global economy, contemporary societies have come to view the educational achievements of their young people as a major component of national competiveness. But there are substantial variations in the strategies employed by different nations. To maximize educational achievements, some nations believe that the provision of a stratified system of schooling is effective, at least for the minority who are able to gain entry to the elite academic stream. In contrast, other nations prefer a more egalitarian strategy to education where all students attend a common school devoid of ability streams until well into their secondary level studies. The egalitarian strategy is believed to be just and fair. But does it enhance educational achievement? Several other strategies are also being advanced, and the same questions can be asked about them. There are a number of studies that explore the academic consequences of different strategies within particular national systems, but there are relatively few studies that explore these questions across several national systems. The Organisation for Economic Co-operation and Development-supported Programme for International Student Assessment (PISA) studies enable a cross-national analysis; but the official reports from the Organisation for Economic Co-operation and Development primarily provide bivariate analyses of these relations whereas a multivariate strategy taking into account several system level variables is preferred. In this paper we examine the historical origins of six contemporary strategies, and draw on the PISA studies to compare the relative efficacy of these strategies relying on path modeling.
The Impact of Structured Self-Monitoring of Blood Glucose Combined With Intensive Education on HbA1c Levels, Hospitalizations, and Quality-of-Life Parameters in Insulin-Treated Patients With Diabetes at Primary Care in Serbia: The Multicenter SPA-EDU Study
Authors: Lalić Nebojša M. , Lalić Katarina , Jotić Aleksandra , Stanojević Dejan , Živojinović Dragana , Janićijević Andrija , Parkin Christopher ,   SPA-EDU Study Group
Published: June 2017

Background: We assessed the effect of structured self-monitoring of blood glucose (SMBG), in combination with intensive education, on metabolic control, SMBG frequency, hospitalizations, cardiovascular risk factors, and quality-of-life parameters in patients with insulin-treated diabetes in primary health care settings in Serbia. Methods: This 6-month, observational, noninterventional study, followed 346 insulin-treated diabetes patients (type 1 diabetes [T1D], n = 57; type 2 diabetes [T2D], n = 289) from 28 primary care centers. Patients attended a 10-day course at the specialized educational center and were followed monthly by their primary care physicians. Patients used a simple paper tool to document 3-day, 7-point glucose profiles prior to each monthly clinic visit. Physicians reviewed the completed forms at each visit and used a standardized education program to provide remedial training. Changes in HbA1c levels, SMBG frequency, metabolic risk factors, and Diabetes Distress Scale (DDS) were assessed. Results: Mean (± SD) HbA1c within the full cohort was significantly improved from baseline at 6 months (8.85 ± 1.17% vs 7.91 ± 1.24%, P < .01). Significant increases in average SMBG frequency per week were seen at 6 months versus baseline (14.6/week vs 4.3/week, P < .001). The mean (± SE) number of hospitalizations due to metabolic conditions was significantly lower during the 6-month study compared to the 6-month period prior to the study (0.14 ± 0.04 vs 0.59 ± 0.09). DDS scores decreased from 39.6 ± 13.9 to 33.9 ± 14.5, P < .01. Conclusion: The use of structured SMBG combined with intensive education was associated with clinically significant reductions in HbA1c, increased SMBG frequency, and improved quality of life.
Short-term prognostic effect of prior cerebrovascular and peripheral artery disease in patients with acute coronary syndrome: Can we do better?
Authors: Cordeiro Filipa , Mateus Pedro S , Ferreira Alberto , Leao Silvia , Moz Miguel , Moreira J Ilidio ,   on behalf of the investigators of the Portuguese Registry of Acute Coronary Syndromes (ProACS)
Published: June 2017

Background: We sought to evaluate the impact of prior cerebrovascular and/or peripheral arterial disease (PAD) on in-hospital outcomes in patients with acute coronary syndromes. Methods: From 1 October 2010 to 26 February 2016, 13,904 acute coronary syndrome patients were enrolled in a national multicentre registry. They were divided into four groups: prior stroke/transient ischaemic attack (stroke/TIA); prior PAD; prior stroke/TIA and PAD; none. The endpoints included in-hospital mortality and a composite endpoint of death, re-infarction and stroke during hospitalization. Results: 6.3% patients had prior stroke/TIA, 4.2% prior PAD and 1.4% prior stroke/TIA and PAD. Prior stroke/TIA and/or PAD patients were less likely to receive evidence-based medical therapies (dual antiplatelet therapy: stroke/TIA= 88.6%, PAD= 86.6%, stroke/TIA+PAD= 85.7%, none= 92.2%, p<0.001; β-blockers: stroke/TIA= 77.1%, PAD= 72.1%, stroke/TIA+PAD= 71.9%, none= 80.8%, p<0.001; angiotensin-converting enzyme inhibitors/angiotensin receptor blockers: stroke/TIA= 86.3%, PAD= 83.6%, stroke/TIA+PAD= 83.2%, none= 87.1%, p=0.030) and to undergo percutaneous revascularization (stroke/TIA= 52.8%, PAD= 45.6%, stroke/TIA+PAD= 43.7%, none= 67.9%, p<0.001), despite more extensive coronary artery disease (three-vessel disease: stroke/TIA= 29.1%, PAD= 38.3%, stroke/TIA+PAD= 38.3%, none= 20.2%, p<0.001). In a multivariable analysis, prior stroke/TIA+PAD was a predictor of in-hospital mortality (odds ratio= 2.828, 95% confidence interval 1.001–7.990) and prior stroke/TIA (odds ratio= 1.529, 95% confidence interval 1.056–2.211), prior PAD (odds ratio= 1.618, 95% confidence interval 1.034–2.533) and both conditions (odds ratio= 3.736, 95% confidence interval 2.002–6.974) were associated with the composite endpoint. Conclusion: A prior history of stroke/TIA and/or PAD was associated with lower use of medical therapy and coronary revascularization and with worst short-term prognosis. An individualized management may improve their poor prognosis.
Caesarean Section Does Not Increase the Risk of Caries in Swedish Children
Authors: Brandquist E. , Dahllöf G. , Hjern A. , Julihn A. 
Published: June 2017

Caesarean section has been shown to affect the health of the child. Only a few studies have investigated whether the mode of delivery is associated with dental caries, and they present conflicting results. Our study investigated whether dental caries was associated with delivery method in Swedish preschool children. This retrospective register-based cohort study included all children born from 2000 to 2003 who were residing in Stockholm County, Sweden, at 3 y of age ( n = 83,147). The study followed the cohort until individuals were 7 y of age. Children examined at 3 and 7 y constituted the final study cohort ( n = 65,259). We dichotomized the key exposure “delivery starts by caesarean section” and analyzed it in univariate analyses as well as in multivariate analyses. The multivariate analyses used 3 outcomes: caries experience at age 3 (deft >0 [decayed, extracted, and filled teeth]), caries increment between 3 and 7 y of age (Δdeft > 0), and caries experience at age 7 (deft > 0). Of the final cohort, 15% ( n = 9,587) were delivered by caesarean section. At 3 y of age, the results showed no statistically significant association between caesarean section and caries experience (odds ratio = 0.92, 95% confidence interval [CI] = 0.82 to 1.04). Between 3 and 7 y of age, the association of caesarean section on caries increment was 0.88 (95% CI = 0.83 to 0.94) and at 7 y of age, 0.88 (caries experience; 95% CI = 0.82 to 0.94). Higher mean values for caries experience and caries increment were observed in vaginally delivered children. We found that preschool children who were delivered by caesarean section do not represent a group with an excess risk of developing dental caries. Furthermore, the statistically significant associations with caries increment and caries experience at age 7 were negative. Knowledge Transfer Statement: Children born by caesarean section are at greater risk of developing asthma and obesity. The proportion of elective caesarean sections without a medical indication has increased over the years; therefore, it is important to know how this mode of delivery affects oral health of the child. The results show that children who are delivered by caesarean section are not at greater risk of developing dental caries, and clinicians can use these findings in their risk assessment.
Redefinition of thérèsemagnanite, NaCo4(SO4)(OH)6Cl·6H2O: new data and relationship to ‘cobaltogordaite’
Authors: Kasatkin Anatoly V. , Plášil Jakub , Škoda Radek , Belakovskiy Dmitriy I. , Marty Joe , Meisser Nicolas , Pekov Igor V. 
Published: June 2017

ABSTRACTThérèsemagnanite was originally described from the Cap Garonne mine, Var, France. Its ideal formula was reported as (Co,Zn,Ni)6(SO4)(OH,Cl)10·8H2O; without crystal structure data, only the powder X-ray diffraction pattern was given. Revision of the holotype material revealed that thérèsemagnanite is identical to ‘cobaltogordaite’ (IMA2014-043), recently described from the Blue Lizard mine, Utah, USA. Thérèsemagnanite is thus redefined in accordance with the new data obtained for the neotype specimen from Blue Lizard (formerly the holotype specimen of ‘cobaltogordaite’) and ‘cobaltogordaite’ has been discredited by the International Mineralogical Association Commission on New Mineral Nomenclature and Classification (IMA CNMNC). Thérèsemagnanite has the ideal, end-member formula NaCo4(SO4)(OH)6Cl·6H2O. The empirical formulae of the holotype (Cap Garonne) and the neotype (Blue Lizard), both based on microprobe analyses and calculated on the basis of 17 O + Cl atoms per formula unit (with fixed 6 OH groups and 6 H2O molecules; H content is calculated by stoichiometry) are (Na0.64K0.09)Σ0.73(Co2.35Zn1.22Ni0.50)Σ4.07S1.02O3.98(OH)6Cl1.02·6H2O and Na1.01(Co1.90Zn1.37Ni0.48Cu0.15Mn0.05)Σ3.95S1.03O4.09(OH)6Cl0.91·6H2O, respectively. Thérèsemagnanite is trigonal,P$\overline 3 $,a= 8.349(3),c= 13.031(2) Å,V= 786.6(4) Å3and Z = 2 (neotype). The strongest powder X-ray diffraction lines are [dobsin Å (hkl) (Irel)]: 13.10 (001)(100), 6.53 (002)(8), 4.173 (110)(4), 3.517 (112)(5), 2.975 (104, 10$\overline 4 $)(4), 2.676 (211)(5) and 2.520 (12$\bar 2$)(5) (neotype). Thérèsemagnanite is a cobalt analogue of gordaite, NaZn4(SO4)(OH)6Cl·6H2O. These minerals represent the gordaite group, accepted by the IMA CNMNC.
RETRACTED ARTICLE: Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis
Authors: Bansal Himanshu , Comella Kristin , Leon Jerry , Verma Poonam , Agrawal Diwaker , Koka Prasad , Ichim Thomas 
Published: June 2017

Abstract
Background
Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. We evaluated the safety and preliminary efficacy of administering SVF and PRP intra-articularly into patients with osteoarthritis grade 1 and 2.

Methods
A total of ten patients underwent a local tumescent liposuction procedure to remove approximately 100 ml of fat tissue from the abdomen. SVF was isolated using an enzyme digestion and resuspended in PRP for intra-articular injection in the knee. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and six-minute walk distance (6MWD) were used to evaluate clinical effects and included measure of patient’s subjective assessment of pain, joint mobility, and physical disability. WOMAC score, 6MWD and laboratory tests were repeated at 3 and 6 months and 1, 1.5 and 2 years. XRAY and MRI were completed at 1 year.

Results
The average total WOMAC score was 64 at baseline and significantly reduced to 52 at 3 months, 46 at 6 months, 42 at 1 year, 38 at 1.5 years, and 41 at 2 years. Patients walked an average of 1310 feet at baseline and demonstrated a statistically significant improvement at 3 and 6 months and 1, 1.5, and 2 years post treatment. Cartilage thickness as determined by MRI improved by at least 0.2 mm in six patients, was unchanged in two patients and decreased by at least 0.2 mm in two patients.

Conclusions
Overall, all of the patients were pleased with the treatment results. They reported a reduction in pain levels, especially after 3 months. More importantly, the procedure demonstrated a strong safety profile with no severe adverse events or complications reported.
Trial registration NCT03089762; Name of registry: http://www.clinicaltrials.gov
RETRACTED ARTICLE: MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway
Authors: Wei Chun-Hua , Wu Gang , Cai Qian , Gao Xi-Can , Tong Fan , Zhou Rui , Zhang Rui-Guang , Dong Ji-Hua , Hu Yu , Dong Xiao-Rong 
Published: June 2017

Abstract
Background
Brain metastasis (BM) is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). Recent studies demonstrated that microRNA-330-3p (miR-330-3p) was involved in NSCLC brain metastasis (BM). However, the exact parts played by miR-330-3p in BM of NSCLC remain unknown. Discovery and development of biomarkers and elucidation of the mechanism underlying BM in NSCLC is critical for effective prophylactic interventions. Here, we evaluated the expression and biological effects of miR-330-3p in NSCLC cells and explored the underlying mechanism of miR-330-3p in promoting cell migration and invasion in NSCLC.

Methods
Stable over-expression and knockdown of miR-330-3p in NSCLC cells was constructed with lentivirus. Expression levels of miR-330-3p in NSCLC cells were quantified by quantitive real-time PCR (qRT-PCR). The effects of miR-330-3p on NSCLC cells were investigated using assays of cell viability, migration, invasion, cell cycle, apoptosis, western blotting, immunohistochemical, and immunofluorescence staining. A xenograft nude mouse model and in situ brain metastasis model were used to observe tumor growth and brain metastasis. The potential target of miR-330-3p in NSCLC cells was explored using the luciferase reporter assay, qRT-PCR, and western blotting. The miR-330-3p targets were identified using bioinformatics analysis and verified by luciferase reporter assay. The correlation between GRIA3 and DNA methyltransferase (DNMT) 1 and DNMT3A was tested by RT-PCR, western blotting, and co-immunoprecipitation (IP).

Results
miR-330-3p was significantly up-regulated in NSCLC cell lines. MTT assay, transwell migration, and invasion assays showed that miR-330-3p promoted the growth, migration, and invasion of NSCLC cells in vitro and induced tumor growth and metastasis in vivo. Luciferase reporter assays showed that GRIA3 was a target of miR-330-3p. qRT-PCR and western blotting exhibited that miR-330-3p promoted the growth, invasion, and migration of NSCLC cells by activating mitogen-activated protein kinase (MAPK)/extracellular-regulated protein kinases (ERK) signaling pathway. Furthermore, miR-330-3p up-regulated the total DNA methylation in NSCLC cells, and co-IP-demonstrated GRIA3 was directly related with DNMT1 and DNMT3A.

Conclusions
miR-330-3p promoted the progression of NSCLC and might be a potential target for the further research of NSCLC brain metastasis.
Hypersomnia and cognitive impairment in a patient with bipolar disorder – a case report
Authors: Szaulińska Katarzyna , Antosik-Wójcińska Anna , Paszkowska Ewa , Święcicki Łukasz , Jarema Marek , Wichniak Adam 
Published: June 2017

Cel pracyObturacyjny bezdech senny (OBS) jest częstym problemem klinicznym, który może mieć poważne następstwa zdrowotne i wikłać przebieg zaburzeń psychicznych. Szacuje się, że występowanie bezdechu sennego w grupie chorych na chorobę afektywną dwubiegunową może wynosić 21-47,5%. Część objawów OBS pokrywa się z niektórymi objawami depresji: senność w ciągu dnia, zaburzenia poznawcze, zmniejszenie napędu, apatia, obniżenie nastroju, anhedonia.MetodaPrezentujemy przypadek pacjenta, u którego objawy depresyjne, utrzymujące się pomimo wielokrotnych zmian leczenia farmakologicznego, okazały się zaostrzone przez ciężkie zaburzenie snu. OBS był również przyczyną wystąpienia u chorego w trakcie leczenia EW poważnych powikłań oddechowych i przedłużonych zaburzeń świadomości.WynikiU pacjenta na podstawie wyniku badania aparatem WatchPAT200 oraz badania polisomnograficznego rozpoznano ciężką postać bezdechu sennego. Zaburzania oddychania prowadziły u pacjenta do prawie całkowitego braku snu REM i istotnego zmniejszenia ilości snu głębokiego oraz skrócenia całkowitego czasu snu. Wdrożenie leczenia dodatnim ciśnieniem oddechowym (CPAP) spowodowało poprawę jakości snu, nadmiernej senności w ciągu dnia i stanu psychicznego pacjenta.WnioskiObecność senności w ciągu dnia, nieustępującej mimo modyfikacji leczenia, wskazuje na konieczność diagnostyki przesiewowej w kierunku OBS. OBS może imitować niektóre objawy depresyjne, zwiększa ryzyko powikłań w trakcie znieczulenia ogólnego i może stanowić jedną z przyczyn lekooporności. Obok negatywnego wpływu zaburzeń oddychania w czasie snu na przebieg CHAD, bezdech senny powoduje również istotne zaburzenia poznawcze takie jak pogorszenie uwagi i czujności, pamięci długotrwałej semantycznej i wzrokowej, funkcji wzrokowo-przestrzennych i wykonawczych.
Blood serum concentrations of kynurenic acid in patients diagnosed with recurrent depressive disorder, depression in bipolar disorder, and schizoaffective disorder treated with electroconvulsive therapy
Authors: Olajossy Marcin , Olajossy Bartosz , Wnuk Sebastian , Potembska Emilia , Urbańska Ewa 
Published: June 2017

Cel pracyCelem pracy jest porównanie stężenia kwasu kynureninowego (KYNA) w surowicy krwi oznaczanego przed leczeniem oraz po 1, 6 i 12 zabiegu elektrycznym (EW) u pacjentów z rozpoznaniem zaburzenia depresyjnego nawracającego (ZDN) i depresji w przebiegu choroby afektywnej dwubiegunowej (DChAD) oraz zaburzenia schizoafektywnego (DSA).MetodaGrupę badaną stanowiło 50 pacjentów z rozpoznaniem ZDN, DChAD i DSA wg ICD-10. Oznaczano stężenie KYNA w surowicy krwi badanych oraz zastosowano skale: MADRS i GAF.WynikiStwierdzono istotne różnice w zakresie stężenia KYNA w surowicy krwi pacjentów leczonych elektrycznie z rozpoznaniem ZDN, DChAD i DSA w porównaniu do grupy kontrolnej. 1.Stężenie KYNA u pacjentów z DChAD przed leczeniem EW i po 12 zabiegu jest istotnie niższe od stężenia KYNA w grupie kontrolnej. 2.Stężenie KYNA w surowicy krwi u pacjentów z ZDN przed leczeniem EW oraz po 1 i 12 zabiegu jest istotnie niższe niż w grupie kontrolnej, a po 6 zabiegu nie różni się istotnie od stężenia w grupie kontrolnej. 3.Wyższe stężenie KYNA w osoczu krwi pacjentów z DChAD przed leczeniem łączy się z większą liczbą faz choroby i gorszym ogólnym funkcjonowaniem przed leczeniem. 4.Stwierdzono istotne zależności między wyższym stężeniem KYNA w surowicy krwi pacjentów z rozpoznaniem ZDN po 1 zabiegu EW a płcią męską oraz między wyższym stężeniem KYNA po 6 zabiegu a nasiloną depresją i gorszym funkcjonowaniem badanych przed leczeniem.WnioskiWyniki wskazują na niższe stężenie KYNA przed leczeniem EW we wszystkich grupach diagnostycznych (nieznamienne w DSA), jak również brak istotnych zmian (w porównaniu z wartościami wyjściowymi) w trakcie terapii EW.
Sintesis Metal Amina Fasa Cair Dari Amoniak Dan Methanol
Authors: Nasikin M. , Mangatur I. 
Published: June 2017

Secara umum terdapat juga jenis amina (MMA), dimetil amina (DMA) dan trimetil amina (TMA). Pada kondisi reaksi setimbang, TMA diperoleh dengan selektivitas tinggi, tetapi produk ini kurang diharapkan karena nilai ekonomisnya rendah dan membentuk azeotrop dengan MMA dan DMA. Pada penelitian ini sintesis metal amina dari amoniak dan methanol dilakukan dengan menggunakan katalis garam heteropoli KxH3-xPW12O40, (NH4)3PW12O40 dan Al2O3 dengan fasa cair. Katalis garam heteropoli adalah shape selective catalyst pada reaksi fasa gas., pada reaksi fasa cair katalis tersebut juga dapat menekan laju pembentukan TMA. Sebagai reaktor digunakan autoclave dengan suhu reaksi 60 dan 80 0C, serta tekanan 16 bar.Hasil karakterisasi dengan metode BET menunjukkan luas permukaan katalis KxH3-xPW12O40 semakin meningkat dengan semakin tingginya harga x. seluruh katalis aktif pada reaksi dan aktifitas katalissemakin meningkat dengan semakin besarnya luas permukaan kecuali untuk katalis Al2O3. Untuk katalis berturutturut ialah K2.5H0.5PW12O40 > (NH4)3PW12O40 > Al2O3 > K2H1PW12O40 > K1H2PW12O40 > K0H3PW12O40. Seluruh katalis mampu menekan selektivitas TMA hingga 100%, dan diperoleh selektivitas DMA yang tinggi (98%). Tidak terbentuknya TMA pada reaksi tidak hany akibat ukuran pori katalis lebih besar dari TMA, namun juga karena perbedaan kebasaan setiap produk. Tingginya selektivitas DMA disebabkan kebasaan DMA yang tinggi sehingga teradsorpsi sangat kuat dipermukaan katalis dan menghentikan reaksi lanjut DMA menjadi TMA. Pada katalis KxH3-xPW12O40 penambahn mmol H+/ mmol methanol dari 2.5 menjadi 5 meningkatkan konversi methanol dari 45 menjadi 47%, sedangkan peningkatan suhu dari 60 0C menjadi 80 0C meningkatkan konversi methanol dari 36% menjadi 46%.Kata kunci : metal amina, methanol, amoniak, reaksi fasa cair
Ekstraksi Minyak Nilam Dengan Pelarut N-Heksana
Authors: Jos B. 
Published: June 2017

Minyak nilam atau “patchouli oil” merupakan komoditas ekspor yang memberikan sumbangan devisa paling besar diantara minyak atsiri yang lain di Indonesia. Minyak nilam digunakan sebagai bahan pewangi dan penahan (bersifat fiksatif) aroma wangi dalam pembuatan parfum, kosmetika, sabun, minyak rambut dan saus tembakau. Pengambilan minyak nilam ini umumnya melalui proses penyulingan dengan air maupun dengan distilasi uap. Pada proses ini rendeman yang dihasilkan hanya sekitar 2- 2,5% dengan konsentrasi patchouli alcohol (PA) sebesar 31%. Oleh karena itu upaya untuk meningkatkan mutu dan rendemen minyak nilam perlu dilakukan. Salah satu metode yang digunakan adalah dengan cara ekstraksi-destilasi. Proses ekstraksi dilakukan dengan menggunakan pelarut n-heksana dan variabel yang digunakan yaitu waktu ekstraksi (30, 60, 90, 120, 150, 180, 210 menit), volume pelarut (2000, 2500, 3000, 3500, 4000, 4500, 5000 ml), serta suhu ekstraksi (30, 40, 50, 60 0C) dengan berat daun nilam yang digunakan sebesar 200 gram, kemudian produk keluaran ekstraksi diteruskan dengan proses distilasi (tahap pemurnian). Hasil penelitian menunjukkan bahwa kondisi operasi optimumdiperoleh pada waktu ekstraksi 120 menit, volume pelarut 3000 ml, dan suhu ekstraksi 30 0C (suhu kamar). Rendemen yang diperoleh sebesar 4,51% dengan konsentrasi patchouli alcohol (PA) sebesar 37%. Ekstraksi-destilasi dengan pelarut n-heksana ini, menghasilkan mutu dan rendemen minyak nilam yang lebih baik daripada proses penyulingan dengan air maupun destilasi uap biasa.Kata kunci : Patchouli alcohol, Rendemen, minyak nilam