bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mycoplasma hominis periaortic abscess following heart–lung transplantation
Authors: Hagiya Hideharu , Yoshida Hisao , Yamamoto Norihisa , Kimura Keigo , Ueda Akiko , Nishi Isao , Akeda Yukihiro , Tomono Kazunori 
Published: March 2017

AbstractWe report the first case of Mycoplasma hominis periaortic abscess after heart–lung transplantation. The absence of sternal wound infection delayed the diagnosis, but the patient successfully recovered with debridement surgeries and long‐term antibiotic therapy. Owing to the difficulty in detection and the intrinsic resistance to beta‐lactams, M. hominis infections are prone to being misdiagnosed and undertreated. M. hominis should be suspected in cases where conventional microbiological identification and treatment approaches fail.
Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by Alternaria rosae: First case report
Authors: Liu Amy W. , Bateman Allen C. , Greenbaum Adam , Garvin Kanishka , Clarridge Jill , Grim Jonathan 
Published: March 2017

AbstractAlternaria species have been reported as a rare cause of fungal infection in organ and stem cell transplant recipients, but to date, no reports have been published of infection in humans caused by Alternaria rosae. Here, we report cutaneous A. rosae infection in a 66‐year‐old farmer with a history of primary myelofibrosis who had undergone allogeneic unrelated donor hematopoietic stem cell transplantation. Forty‐nine days post transplant, he presented with a nodule on the thumb with no findings suggestive of disseminated infection. Pathology, culture, and molecular speciation showed the nodule was caused by cutaneous A. rosae. He had been on voriconazole as antifungal prophylaxis, but was found to have a subtherapeutic voriconazole level. He was switched to posaconazole based on published in vitro data showing its superior efficacy in Alternaria treatment. Susceptibility testing showed that the A. rosae isolate was indeed susceptible to posaconazole. His cutaneous lesion remained stable, but he died from respiratory failure secondary to lobar pneumonia. At lung autopsy, A. rosae was not identified in the lungs. We believe this to be the first published report, to our knowledge, of A. rosae infection in humans.
Blood product utilization in human upper‐extremity transplantation: challenges, complications, considerations, and transfusion protocol conception
Authors: Raval Jay S. , Gorantla Vijay S. , Shores Jaimie T. , Lee W.P. Andrew , Planinsic Raymond M. , Rollins‐Raval Marian A. , Brandacher Gerald , King Karen E. , Losee Joseph E. , Kiss Joseph E. 
Published: March 2017

BACKGROUNDUpper‐extremity transplantation (UET) is a reality. Immunologic, functional, and graft survival outcomes have been encouraging. However, these complex reconstructions have unique considerations that pose distinct challenges. Transplant programs have reported morbidity and mortality due to significant intraoperative blood losses, but similar data are scant during other phases of recovery. We report experience from two centers on complete blood component demands and utilization with UET.STUDY DESIGN AND METHODSInpatient medical records of UET recipients from intraoperative (time from initiation of transplant surgery to exit from the operative suite) and postoperative (exit from the operative suite to discharge from the hospital) phases were retrospectively reviewed.RESULTSSix patients received various UETs and mean (±SD) postoperative hospital stay was 46 (±14.4) days. Mean (±SD) intraoperative blood unit utilization was 14.8 (±10.2) red blood cells (RBCs), 10.5 (±11.8) plasma, 0.8 (±1.2) platelets (PLTs), and 0.3 (±0.8) cryoprecipitate units. Mean postoperative blood unit utilization was 9.3 (±10.4) RBCs, 5.3 (±6.7) plasma, 1.2 (±2.0) PLTs, and 0.7 (±1.6) cryoprecipitate units. Both intraoperative and postoperative blood utilization for unilateral versus bilateral transplant were different, but not significantly so. However, total inpatient blood use in bilateral transplants was significantly greater than in unilateral transplants.CONCLUSIONSubstantial blood loss may occur in UET and require transfusion of many blood components, primarily RBCs and plasma. We propose an UET transfusion protocol and suggest that centers preparing to perform these transplants should actively engage the transfusion medicine service to ensure availability and access to appropriate blood components for the entire hospitalizations of these unique patients.
Frequency of Trypanosoma cruzi parasitemia among infected blood donors with a potential association between parasite lineage and transfusion transmission
Authors: Leiby David A. , Nguyen Megan L. , Proctor Melanie C. , Townsend Rebecca L. , Stramer Susan L. 
Published: March 2017

BACKGROUNDTrypanosoma cruzi is endemic to the Americas where it demonstrates multiple lineages over a vast geographic range (i.e., United States to Argentina). These lineages possess divergent geographic and biologic characteristics, including variations in disease manifestations. Herein, we report the frequency of parasitemia among seropositive US blood donors and the potential association between parasite lineage and transfusion transmission.STUDY DESIGN AND METHODSBlood donors identified as T. cruzi seropositive during screening were enrolled in follow‐up studies, including hemoculture testing and a risk factor questionnaire. Positive hemocultures were expanded to obtain sufficient parasites for molecular lineage determination and analysis. Country of birth, obtained from the questionnaire, was used to predict parasite lineage in the absence of demonstrable parasitemia for infected donors.RESULTSEighteen (6.8%) of 263 seropositive donors were hemoculture positive. Among the 17 hemocultures expanded for lineage determination, TcV was identified more frequently (n = 12), compared to TcI (n = 2), TcII (n = 1), and TcVI (n = 2). When presumptive parasite lineages were compared to hemoculture results, only two of 157 (1.3%) TcI versus 13 of 38 (34.2%) TcII/TcV/TcVI non‐US donors were parasitemic; three of 44 (6.8%) US donors were TcV or TcVI.CONCLUSIONSBased on lineage determination for donors with parasitemia; hemoculture positivity associated with presumptive parasite lineage; and implicated donors from US, Canadian, and Spanish transfusion cases, donors from Southern South America are significantly more likely to have parasitemia and transmit infection to blood recipients (TcII, TcV, or TcVI vs. TcI). Thus, parasite lineage may be associated with risk of transfusion‐transmitted T. cruzi.
Consideration of hydromorphology and sediment in the implementation of the EU water framework and floods directives: a comparative analysis of selected EU member states
Authors: Nones Michael , Gerstgraser Christoph , Wharton Geraldene 
Published: March 2017

AbstractThe EU Water Framework and Floods Directives represent important legislative instruments introduced in the water policy during the last two decades. Despite their holistic and complementary approaches, which should yield many benefits, the lack of importance given to the consideration of hydromorphology and sediments is a weakness. This will hinder the achievement of the Directives' goals, since hydrology and geomorphology of rivers and the character and dynamics of sediments are essential components of the aquatic habitat and ecosystem health. The entrainment, transport and deposition of sediments determine the interrelationships between river channel geometry and flow regime, which affect flood risk. The paper reports on the findings of a survey undertaken in 2015 as part of the HYTECH project, which questioned 20 EU Water Authorities about the importance they attached to hydromorphological quality elements and sediment transport during the implementation cycles of both Directives.
DIALECTICS OF POLITICS AND RELIGION IN INDONESIA
Authors: Eka Putra Okrisal , Jandra Mifedwil 
Published: March 2017

This study describes the relationship between religion and social life with politics as one aspect. The issue is the imbalance that occurs when Muslims as majority in Indonesia is not the sole determinant of political life journey., Parti-Islam party representing the political aspirations of Muslims never be a winner in every election. At best, they can only act as a "disturbing" factor in the election of the president and vice president. The question is what happens to Muslims in Indonesia so that every democratic process as elections only be used by those who want to take power in this country. This research is qualitative descriptive. Data retrieved through documentation and interviews. Later, the data were analyzed with descriptive analysis. The unit of analysis in social institutions in this regard is the religious and political parties. Data search is through books, journals and writings of Islamic political thinkers. urthermore, interpretation of data and grouping of data is done in accordance with the type of problem and then analyzed through an explanation to determine the variables. This research can enrich 'the wealth of thought in politics and in the fight for the aspirations of Muslims in civic life as well as in the preparation of an appropriate strategy to no longer be deceived by their political opponents. Muslims understanding of strength, verses and hadith are always multi-interpretative power that spawned a variety of comprehension and crystallize into a solid group. Differences occur is difficult to put together in one political group. Primordial existence more prominent than thinking about the progress of Muslims in the life of state and society. Color portrait of Muslim politics, we look long dialectic between propaganda and politics of the New Order, which is a long fight between Muslims and the government's birth that cause antipathy to each policy. It's realizing the physical strain that produced casualties on both sides. Keywords: political relations, government, Muslims
THE ROLE OF RASTIKA’S GLASS PAINTING AS A UNIQUE ARTWORK IN SUPPORTING TOURISM IN CIREBON
Authors: Sugesti Ikariya , Susilawati Susilawati 
Published: March 2017

The Cirebon glass painting is a traditional artwork which showed how several cultures such as Chinese, Islam, and Hindu combined as one. Rastika is a glass painting pioneer from Cirebon has shown how the object variation, background development, and calligraphy in his artwork. His glass painting serves the beauty of itself and he has reformed traditional themes in glass paintings. This is an art involving design, style, theme, and the pattern, that always growth, renewal, and friction, so that it produces a new and prim painting technique. A combination of rocks and clouds and that of a dragon, which are quite often found in Cirebon's glass paintings, are also evident in his creations. The color harmony suggests western nuances, which are obviously the outcome of his wide acquaintanceship with fine art academics. Rastika has produced lots of glass painting, producing the classic and modern classic theme and pattern. This research was conducted to introduce Rastika’s glass painting as a unique artwork and to find out the role of it to support the tourism part in Cirebon. Keywords: Rastika’s glass painting, artwork, culture, tourism
MANAGERIAL INSPIRATION IN THE TRADITIONAL PESANTREN
Authors: Karim Abdul 
Published: March 2017

This research deepens the concept of Henry Mintzberg who gives hard criticism that most managers can not be classified definitively into management functions. Thus allowing manager to play his/her managerial’s roles which consist of interpersonal, informational, and decisional. So, this study will synthesize interpersonal’s role of the managers. Meanwhile, an independent position of this research is the manager's inspiration to play his/her roles in decision making. The main objective of this research is leader’s inspiration through the process of meditation, mediation, and reflection of the main Kyais in Pesantren Bendakerep Cirebon Indonesia. This objective can be answered deeply only with qualitative’s kind of research through cultural approach. The data which is collected through interview, observation and documents analysis, after going through triangulation stage, will be analyzed through categorization, reduction, and interpretation. The findings show that the Kyai’s efforts of decision making is by obeying the ancestor inheritances both materialistic and imaterialistic, to dig the inspiration through meditation, mediation and reflection in the form of decisions. Keywords: Managerial roles, leadership inspiration, traditional pesantren
RELIGIOSITY OF CIREBONESE SOCIETY CULTURE IN THE ORAL TRADITION PEPUJIAN
Authors: Kamaluddin Muhammad 
Published: March 2017

Cirebonese society and its culture grew and developed from a long history of the oldest Islamic Sultanate in West Java led by Sunan Gunung Jati. As the King of the Sultanate and at the same time called the Waliyullah, such a variety forms of tradition are held as the cultural expression of his citizen. One of it is the oral tradition pepujian. This tradition has been exist in the mid of the society until now. This research is conducted as a study of public religiosity. It is seen from the oral tradition pepujian is linked with the culture of the society. It is link with the ideaof semiotics theory of Claude Lévi-Strauss (1904) in anthropology studies using language approach. The methodology used is paradigm from the qualitative research. Through the linguistics anthropology framework, researcher involves in the community activities and being part of them. So it is eventually discovered that the oral tradition pepujian in the culture of Cirebonese speakers is a verse of poetry containing Islamic teachings about faith and worship. It is spoken in the form of song as an expression of their cultural religiosity. Keywords: Cirebonese society, culture, oral tradition, religiosity.RELIGIOSITY OF CIREBONESE SOCIETY CULTURE IN THE ORAL TRADITION PEPUJIAN
A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia
Authors: Gunduz‐Bruce Handan , Kenney Joshua , Changlani Suravi , Peixoto Aldo , Gueorguieva Ralitza , Leone Cheryl , Stachenfeld Nina 
Published: March 2017

New Findings
What is the central question of this study?
Can the change in plasma arginine vasopressin concentration (P[AVP]) in response to osmotic stimulation (POsm) serve as a biomarker for NMDA receptor signalling in schizophrenia and depression and thereby distinguish between these mental illnesses?

What is the main finding and its importance?
In response to hyperosmotic challenge, depressed subjects showed increased P[AVP] response compared with healthy control and schizophrenic subjects. However, schizophrenic subjects were not different from healthy control subjects in this small sample. The ‘P[AVP] response to POsm’ is a suitable biomarker to distinguish depressed versus schizophrenic patients when used with psychiatric screening. This is the first objective physiological measure for schizophrenia or depression.

Altered NMDA receptor activity and glutamate signalling might underlie the pathogenesis of both schizophrenia and depression in subgroups of patients. In schizophrenia, pharmacological modelling, post‐mortem and imaging data suggest reduced NMDA signalling. In contrast, recent clinical trials demonstrating the efficacy of the NMDA antagonist ketamine in severely depressed patients suggest increased NMDA receptor signalling. We conducted a proof‐of‐concept study to assess whether there is any in vivo evidence for an inverse association in depression and schizophrenia with respect to the NMDA receptor function. For this purpose, we used a translational approach, based on findings from animal studies that NMDA receptor is a key mediator of arginine vasopressin (AVP) release into the bloodstream. Using hypertonic saline to increase plasma osmolality (POsm) and thereby induce AVP release, as done in animal studies, we found that in depressed patients the NMDA receptor‐mediated AVP release induced by hypertonic saline infusion was significantly increased [0.24 (0.15) pg ml−1 mosmol−1, P < 0.05] compared with schizophrenia patients [0.07 (0.07) pg ml−1 mosmol−1]. Slopes for healthy control subjects were 0.11 (0.09) pg ml−1 mosmol−1 which was less than the depressed group. These findings are consistent with implicated NMDA receptor‐related abnormalities in depression and schizophrenia in subgroups of patients and provide the first in vivo evidence of this dichotomy.
Virtual Reality Training With Three-Dimensional Video Games Improves Postural Balance and Lower Extremity Strength in Community-Dwelling Older Adults
Authors: Lee Yongwoo , Choi Wonjae , Lee Kyeongjin , Song Changho , Lee Seungwon 
Published: March 2017

Avatar-based three-dimensional technology is a new approach to improve physical function in older adults. The aim of this study was to use three-dimensional video gaming technology in virtual reality training to improve postural balance and lower extremity strength in a population of community-dwelling older adults. The experimental group participated in the virtual reality training program for 60 min, twice a week, for 6 weeks. Both experimental and control groups were given three times for falls prevention education at the first, third, and fifth weeks. The experimental group showed significant improvements not only in static and dynamic postural balance but also lower extremity strength (p < .05). Furthermore, the experimental group was improved to overall parameters compared with the control group (p < .05). Therefore, three-dimensional video gaming technology might be beneficial for improving postural balance and lower extremity strength in community-dwelling older adults.
The Pictorial Scale of Perceived Movement Skill Competence: Determining Content and Construct Validity for Brazilian Children
Authors: Valentini Nadia C. , Barnett Lisa M. , Bandeira Paulo Felipe Ribeiro , Nobre Glauber Carvalho , Zanella Larissa Wagner , Sartori Rodrigo Flores 
Published: March 2017

The pictorial scale of Perceived Movement Skill Competence (PMSC) was developed to assess young children’s perceptions of competence in fundamental motor skills (FMS) and in active play (AP). The objectives of the present study were to assess validity and reliability with Brazilian children. Nineteen health-related professionals and 331 children (4 to 8 years old) were enrolled in the study. Kappa concordance coefficient, intra-class correlation coefficient (ICC), polychoric correlations, and confirmatory factor analyses (CFA) were used. The back-reverse translation prevents the bias of a single translation. Experts and professionals confirmed the clarity and pertinence of the items with high agreement scores (values > .90). Test-retest reliability results showed strong ICC (values > .90). The Cronbach’s alpha coefficient showed good internal consistency (α values from .70–.85). The CFA showed appropriate fit indexes for a three-factor model (i.e., six object control, six locomotion, and six AP items) and a two-factor model (i.e., 12 FMS and six AP items). However, the two-factor model showed superior indexes (χ2/df = 3.1; Root Mean Square Error of Approximation = .06; Goodness-Of-Fit Index = .90; Comparative Fit Index = .91; Akaike Information Criterion = 485.8). The PMSC is a valid and reliable assessment to use in Brazil.
Comparison Between Wrist-Worn and Waist-Worn Accelerometry
Authors: Loprinzi Paul D. , Smith Brandee 
Published: March 2017

Objective:To use the most recent ActiGraph model (GT9X) to compare counts per minute (CPM) estimates between wrist-worn and waist-worn attachment sites.Methods:Participants completed 2 conditions (laboratory [N = 13] and free-living conditions [N = 9]), in which during both of these conditions they wore 2 ActiGraph GT9X accelerometers on their nondominant wrist (side-by-side) and 2 ActiGraph GT9X accelerometers on their right hip in line with the midaxillary line (side-by-side). During the laboratory visit, participants completed 5 treadmill-based trials all lasting 5 min: walk at 3 mph, 3.5 mph, 4 mph, and a jog at 6 mph and 6.5 mph. During the free-living setting, participants wore the monitors for 8 hours. Paired t test, Pearson correlation and Bland-Altman analyses were employed to evaluate agreement of CPM between the attachment sites.Results:Across all intensity levels and setting (laboratory and free-living), CPM were statistically significantly and substantively different between waist- and wrist-mounted accelerometry.Conclusion:Attachment site drastically influences CPM. As such, extreme caution should be exercised when comparing CPM estimates among studies employing different attachment site methodologies, particularly waist versus wrist.
Minimum Accelerometer Wear Time in Infants: A Generalizability Study
Authors: Pitchford E. Andrew , Ketcheson Leah R. , Kwon Hyun-Jin , Ulrich Dale A. 
Published: March 2017

Background:Research measuring physical activity behaviors during infancy is critical for evaluation of early intervention efforts to reduce rapid weight gain. There is little known about the physical activity patterns of infants, due in part to limited evidence for measurement procedures. This study sought to determine the minimal number of days and hours of accelerometry needed to reliably measure daily physical activity in infants using Generalizability (G) theory.Methods:A total of 23 infants (14 female, 9 male) wore an accelerometer on the right ankle and right wrist for 7 days. Data were manually cleaned to remove activity counts not produced by the infant. G theory analyses were conducted on the average counts per epoch.Results:Reliable estimates were observed with at least 2 days (G & Φ = .910) and 12 hours (G = .806, Φ = .803) at the ankle, and with at least 3 days (G & Φ = .906) and 15 hours (G = .802, Φ = .800) at the wrist.Conclusions:These results provide some of the first guidelines for objective physical activity measurement during infancy. Accelerometer monitoring periods of at least 3 days including all daytime hours appear to be sufficient for reliable measurement.
Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole
Authors: Kovanda Laura L. , Marty Francisco M. , Maertens Johan , Desai Amit V. , Lademacher Christopher , Engelhardt Marc , Lu Qiaoyang , Hope William W. 
Published: March 2017

ABSTRACT

Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral isavuconazole exposure using population PK modeling. This study included patients treated in two phase 3 trials of isavuconazole, SECURE for treatment of invasive aspergillosis (IA) and other filamentous fungi and VITAL for patients with mucormycosis, invasive fungal disease (IFD) caused by other rare fungi, or IA and renal impairment. Mucositis was reported by site investigators and its impact on oral bioavailability was assessed. Use of the oral formulation was at the discretion of the investigator. Patients with plasma samples collected during the use of isavuconazonium sulfate were included in the construction of population PK model. Of 250 patients included, 56 patients had mucositis at therapy onset or as an adverse event during oral isavuconazole therapy. Levels of oral bioavailability were comparable, at 98.3% and 99.8%, respectively. The average drug exposures (average area under the curve [AUC
ave
]) calculated from either the mean or median parameter estimates were not different between patients with and without mucositis. Mortality and overall clinical responses were similar between patients receiving oral therapy with and without mucositis. We found that isavuconazole exposures and clinical outcomes in this subset of patients with mucositis who were able to take oral isavuconazonium sulfate were comparable to those in patients without mucositis, despite the difference in oral bioavailability. Therefore, mucositis may not preclude use of the oral formulation of isavuconazonium sulfate.