bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting ischemic stroke after carotid artery stenting based on proximal calcification and the jellyfish sign
Authors: Ichinose Nobuhiko , Hama Seiji , Tsuji Toshio , Soh Zu , Hayashi Hideaki , Kiura Yoshihiro , Sakamoto Shigeyuki , Okazaki Takahito , Ishii Daizo , Shinagawa Katsuhiro , Kurisu Kaoru 
Published: July 2017

OBJECTIVECarotid artery stenting (CAS) has been considered to prevent ischemic strokes caused by stenosis of the cervical carotid artery. The most common complication of CAS is new cerebral infarction. The authors have previously reported that the jellyfish sign—the rise and fall of the mobile component of the carotid plaque surface detected by carotid ultrasonography—suggests thinning and rupture of the fibrous cap over the unstable plaque content, such as the lipid-rich necrotic core or internal plaque hemorrhage. The authors’ aim in the present study was to evaluate the risk of a new ischemic lesion after CAS by using many risk factors including calcification (size and location) and the jellyfish sign.METHODSEighty-six lesions (77 patients) were treated with CAS. The presence of ischemic stroke was determined using diffusion-weighted imaging (DWI). Risk factors included calcification of the plaque (classified into 5 groups for size and 3 groups for location) and the jellyfish sign, among others. Multiple linear regression analysis (stepwise analysis and partial least squares [PLS] analysis) was conducted, followed by a machine learning analysis using an artificial neural network (ANN) based on the log-linearized gaussian mixture network (LLGMN). The additive effects of the jellyfish sign and calcification on ischemic stroke after CAS were examined using the Kruskal-Wallis test, followed by the Steel-Dwass test.RESULTSThe stepwise analysis selected the jellyfish sign, proximal calcification (proximal Ca), low-density lipoprotein (LDL) cholesterol, and patient age for the prediction model to predict new DWI lesions. The PLS analysis revealed the same top 3 variables (jellyfish sign, proximal Ca, and LDL cholesterol) according to the variable importance in projection scores. The ANN was then used, showing that these 3 variables remained. The accuracy of the ANN improved; areas under the receiver operating characteristic curves of the stepwise analysis, the PLS analysis, and the ANN were 0.719, 0.727, and 0.768, respectively. The combination of the jellyfish sign and proximal Ca indicates a significantly increased risk for ischemic stroke after CAS.CONCLUSIONSThe jellyfish sign, proximal Ca, and LDL cholesterol were considered to be important predictors for new DWI lesions after CAS. These 3 factors can be easily determined during a standard clinical visit. Thus, these 3 variables—especially the jellyfish sign and proximal Ca—may be useful for reducing the ischemic stroke risk in patients with stenosis of the cervical carotid artery.
Surgical management of spinal osteoblastomas
Authors: Versteeg Anne L. , Dea Nicolas , Boriani Stefano , Varga Peter P. , Luzzati Alessandro , Fehlings Michael G. , Bilsky Mark H. , Rhines Laurence D. , Reynolds Jeremy J. , Dekutoski Mark. B. , Gokaslan Ziya L. , Germscheid Niccole M. , Fisher Charles G. 
Published: July 2017

OBJECTIVEOsteoblastoma is a rare primary benign bone tumor with a predilection for the spinal column. Although of benign origin, osteoblastomas tend to behave more aggressively clinically than other benign tumors. Because of the low incidence of osteoblastomas, evidence-based treatment guidelines and high-quality research are lacking, which has resulted in inconsistent treatment. The goal of this study was to determine whether application of the Enneking classification in the management of spinal osteoblastomas influences local recurrence and survival time.METHODSA multicenter database of patients who underwent surgical intervention for spinal osteoblastoma was developed by the AOSpine Knowledge Forum Tumor. Patient data pertaining to demographics, diagnosis, treatment, cross-sectional survival, and local recurrence were collected. Patients in 2 cohorts, based on the Enneking classification of the tumor (Enneking appropriate [EA] and Enneking inappropriate [EI]), were analyzed. If the final pathology margin matched the Enneking-recommended surgical margin, the tumor was classified as EA; if not, it was classified as EI.RESULTSA total of 102 patients diagnosed with a spinal osteoblastoma were identified between November 1991 and June 2012. Twenty-nine patients were omitted from the analysis because of short follow-up time, incomplete survival data, or invalid staging, which left 73 patients for the final analysis. Thirteen (18%) patients suffered a local recurrence, and 6 (8%) patients died during the study period. Local recurrence was strongly associated with mortality (relative risk 9.2; p = 0.008). When adjusted for Enneking appropriateness, this result was not altered significantly. No significant differences were found between the EA and EI groups in regard to local recurrence and mortality.CONCLUSIONSIn this evaluation of the largest multicenter cohort of spinal osteoblastomas, local recurrence was found to be strongly associated with mortality. Application of the Enneking classification as a treatment guide for preventing local recurrence was not validated.
Increase in the Amplitude of Line-of-sight Velocities of the Small-scale Motions in a Solar Filament before Eruption
Authors: Seki Daikichi , Otsuji Kenichi , Isobe Hiroaki , Ishii Takako T. , Sakaue Takahito , Hirose Kumi 
Published: July 2017

Abstract
We present a study on the evolution of the small-scale velocity field in a solar filament as it approaches the eruption. The observation was carried out by the Solar Dynamics Doppler Imager (SDDI) that was newly installed on the Solar Magnetic Activity Research Telescope at Hida Observatory. The SDDI obtains a narrowband full-disk image of the Sun at 73 channels from Hα − 9.0 Å to Hα + 9.0 Å, allowing us to study the line-of-sight (LOS) velocity of the filament before and during the eruption. The observed filament is a quiescent filament that erupted on 2016 November 5. We derived the LOS velocity at each pixel in the filament using the Becker’s cloud model, and made the histograms of the LOS velocity at each time. The standard deviation of the LOS velocity distribution can be regarded as a measure for the amplitude of the small-scale motion in the filament. We found that the standard deviation on the previous day of the eruption was mostly constant around 2–3 km s−1, and it slightly increased to 3–4 km s−1 on the day of the eruption. It shows a further increase, with a rate of 1.1 m s−2, about three hours before eruption, and another increase, with a rate of 2.8 m s−2, about an hour before eruption. From this result we suggest that the increase in the amplitude of the small-scale motions in a filament can be regarded as a precursor of the eruption.
Luossa and Laks
Authors: Law John , Joks Solveig 
Published: July 2017

When technoscience and state policy interact with indigenous knowledges and practices they usually do so asymmetrically. Within relations of domination indigenous knowledges are treated as ‘beliefs’ or ‘culture’ whereas technoscience qualifies as ‘knowledge’ or truth. This paper explores one such interaction: a controversy in north Norway and Finland between biological modellers and policymakers on the one hand, and Sámi fisherpeople on the other. The scientists and the policymakers argue that salmon numbers are falling in the Deatnu (Tana) river as a result of overfishing, and seek to limit fishing. Local fishermen partially agree, but argue that other factors (and especially the protection of predators) are also crucial. They also resist restrictions being imposed on local (and often Sámi) driftnet fishing practices. The paper treats this controversy as epistemological, political and metaphysical, with a particular focus on the last of these. The metaphysical assumptions enacted by technoscience –and in particular its commitments to nature-culture dualism and a singular ‘one-world’ ontology– are explored. These commitments are shown to be absent in Sámi practices. It is argued, following other work in postcolonial anthropology, that those embedded assumptions prevent technoscience and policy practices from recognising metaphysical difference, and so allow policymakers and scientists to refuse the possibility that there might be multiple and different worlds. The paper concludes by arguing that if less dominatory relations between science and policy on the one hand, and Sámi practices and knowledges on the other, are to be achieved it will be important to attend: (a) to the down-to-earth material practices of knowledge production; and (b) to the significance of metaphysical difference within and between those practices. It will also be important: (c) to create ways of knowing that recognise and enact differences rather than hoping to seek consensus.
L’espace de l’activité : Une construction conjointe de l’activité et de l’espace
Authors: Heddad Nadia 
Published: July 2017

Toute activité humaine requiert un espace. La situation de travail n’échappe pas à cette exigence. Ce texte apporte un éclairage sur la relation et le rôle de l’espace dans la réalisation de l’activité. L’objet de la réflexion consiste à revisiter la notion d’espace dans la situation de travail. Les résultats d’une analyse du travail réalisée en milieu postal sont exploités pour proposer le concept d’espace de l’activité. Il s’agit de l’espace modelé et agi dans et par l’activité de travail. Il s’inscrit dans un double cadre théorique, construit sur la base de l’approche instrumentale et de la théorie de l’énaction. L’approche instrumentale permet de montrer comment l’espace donné est modifié et ajusté dans l’activité. L’artefact comporte le dispositif matériel (éléments du bâti, matériels), mais aussi organisationnel (agencements). La théorie défendue par l’énaction vise à saisir la dimension émergente de l’espace de l’activité dans sa construction simultanée et imbriquée au déroulé de l’activité, notamment dans le faire des agents en situation. Elle permet de mettre la focale sur les formes d’interaction et communications (verbales ou non) s’appuyant sur l’espace.	La visée est de développer en ergonomie la réflexion sur la dimension spatiale. Le concept d’espace de l’activité constitue une nouvelle unité d’analyse permettant la prise en compte de la dimension spatiale propre à l’activité dans la situation de travail.
The HIRLAM fast radiation scheme for mesoscale numerical weather prediction models
Authors: Rontu Laura , Gleeson Emily , Räisänen Petri , Pagh Nielsen Kristian , Savijärvi Hannu , Hansen Sass Bent 
Published: July 2017

Abstract. This paper provides an overview of the HLRADIA shortwave (SW) and longwave (LW) broadband radiation schemes used in the HIRLAM numerical weather prediction (NWP) model and available in the HARMONIE-AROME mesoscale NWP model. The advantage of broadband, over spectral, schemes is that they can be called more frequently within the model, without compromising on computational efficiency. In mesoscale models fast interactions between clouds and radiation and the surface and radiation can be of greater importance than accounting for the spectral details of clear-sky radiation; thus calling the routines more frequently can be of greater benefit than the deterioration due to loss of spectral details. Fast but physically based radiation parametrizations are expected to be valuable for high-resolution ensemble forecasting, because as well as the speed of their execution, they may provide realistic physical perturbations. Results from single-column diagnostic experiments based on CIRC benchmark cases and an evaluation of 10 years of radiation output from the FMI operational archive of HIRLAM forecasts indicate that HLRADIA performs sufficiently well with respect to the clear-sky downwelling SW and longwave LW fluxes at the surface. In general, HLRADIA tends to overestimate surface fluxes, with the exception of LW fluxes under cold and dry conditions. The most obvious overestimation of the surface SW flux was seen in the cloudy cases in the 10-year comparison; this bias may be related to using a cloud inhomogeneity correction, which was too large. According to the CIRC comparisons, the outgoing LW and SW fluxes at the top of atmosphere are mostly overestimated by HLRADIA and the net LW flux is underestimated above clouds. The absorption of SW radiation by the atmosphere seems to be underestimated and LW absorption seems to be overestimated. Despite these issues, the overall results are satisfying and work on the improvement of HLRADIA for the use in HARMONIE-AROME NWP system is ongoing. In a HARMONIE-AROME 3-D forecast experiment we have shown that the frequency of the call for the radiation parametrization and choice of the parametrization scheme makes a difference to the surface radiation fluxes and changes the spatial distribution of the vertically integrated cloud cover and precipitation.
To what extent does patient experience account for variation in patient satisfaction with a healthcare system?
Authors: Kumah Emmanuel 
Published: July 2017

Background: Patient experience and patient satisfaction, the two recognized indicators for assessing the quality of healthcare, are related, but distinct concepts. While there is existing evidence concerning a statistically significant association between these two concepts, research on the extent to which patient experience accounts for variation in patients’ overall satisfaction with health services has produced contradictory results. Objectives: The primary aim of this paper was to determine the extent to which satisfaction with a healthcare system is explained by patient experience. A secondary objective was to identify the aspects of patient experience that relate most strongly to satisfaction with health services.Methods: The study was a secondary analysis of quantitative data from the 2006 Consumer Assessment of Healthcare Providers and Systems (CAHPS) Survey. Multivariate regression analysis was used to assess the association between global satisfaction and CAHPS domains of patient-reported experience with healthcare. Pearson product moment correlation coefficients were computed to ascertain the aspects of patients’ experiences that have strong association with their overall satisfaction. Findings: Much (67.4%) of the variation in overall patient satisfaction was accounted for by patient experience. Factors related to patient-professional relationship related strongly with patients’ overall satisfaction with health servicesConclusion: Patient experience of care is a major determinant of patients’ overall satisfaction with a healthcare system and the two concepts are not marginally related.
Community-based medical education in action: primary care physicians’ perceptions
Authors: Yakhforoshha Afsaneh , Oveisi Dr. Sonia , Sarchami Dr. Ramin , Mahmoodi-Bakhtiari Dr. Behrooze 
Published: July 2017

Introduction and objectives: During the last decade, in response to wide ranging changes in healthcare systems and physicians' roles, the medical curriculum has undergone some modification. To achieve high quality education, 2 strategies are suggested: (1) Community-based medical education and (2) Community-oriented medical education. During the process of curriculum planning, the planners need to identify the potential areas for improvement and to guarantee the quality of instruction. This study aimed to determine the viewpoints of medical graduates from Qazvin University of Medical Science (QUMS), Tehran, on community medicine internship and clerkship programs (CMICP) in order to assist better decision-making by policymakers.Methods: In this qualitative study, the conventional content analysis approach was employed. Data were gathered from 20 primary practitioners of QUMS through individual semi-structured interviews and focus group discussions (FGD) which were continued until data saturation occured. The interviews were transcribed and analyzed immediately after the interviews. To analyze the data, one note was employed and to analyze the qualitative data, inductive method was used. The unit of analysis was selected and labeled using an open coding system. Then, the similar open codes were categorized in subthemes and finally the subthemes were organized into the main themes. Findings: The results of data analysis identified 4 main themes including: planned curriculum, delivered curriculum, hidden curriculum and curriculum evaluation.Conclusion: Many graduates suggest that, in addition to curriculum renewal, curriculum planners should identify mediated factors in CMICP to prepare graduates to practise in healthcare settings.
Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok
Authors: Kroon Eugène D.M.B. , Phanuphak Nittaya , Shattock Andrew J. , Fletcher James L.K. , Pinyakorn Suteeraporn , Chomchey Nitiya , Akapirat Siriwat , de Souza Mark S. , Robb Merlin L. , Kim Jerome H. , van Griensven Frits , Ananworanich Jintanat , Wilson David P. ,   RV254/SEARCH 010 Study Group
Published: July 2017

AbstractIntroduction: Antiretroviral treatment (ART) reduces HIV transmission. Despite increased ART coverage, incidence remains high among men who have sex with men (MSM) in many places. Acute HIV infection (AHI) is characterized by high viral replication and increased infectiousness. We estimated the feasible reduction in transmission by targeting MSM with AHI for early ART.Methods: We recruited a cohort of 88 MSM with AHI in Bangkok, Thailand, who initiated ART immediately. A risk calculator based on viral load and reported behaviour, calibrated to Thai epidemiological data, was applied to estimate the number of onwards transmissions. This was compared with the expected number without early interventions.Results: Forty of the MSM were in 4th‐generation AHI stages 1 and 2 (4thG stage 1, HIV nucleic acid testing (NAT)+/4thG immunoassay (IA)‐/3rdG IA–; 4thG stage 2, NAT+/4thG IA+/3rdG IA–) while 48 tested positive on third‐generation IA but had negative or indeterminate western blot (4thG stage 3). Mean plasma HIV RNA was 5.62 log10 copies/ml. Any condomless sex in the four months preceding the study was reported by 83.7%, but decreased to 21.2% by 24 weeks on ART. After ART, 48/88 (54.6%) attained HIV RNA <50 copies/ml by week 8, increasing to 78/87 (89.7%), and 64/66 (97%) at weeks 24 and 48, respectively. The estimated number of onwards transmissions in the first year of infection would have been 27.3 (95% credible interval: 21.7–35.3) with no intervention, 8.3 (6.4–11.2) with post‐diagnosis behaviour change only, 5.9 (4.4–7.9) with viral load reduction only and 3.1 (2.4–4.3) with both. The latter was associated with an 88.7% (83.8–91.1%) reduction in transmission.Conclusions: Disproportionate HIV transmission occurs during AHI. Diagnosis of AHI with early ART initiation can substantially reduce onwards transmission.
The effects of melatonin on bovine uniparental embryos developmentin vitroand the hormone secretion of COCs
Authors: Wang Shujuan , Liu Baoru , Liu Wenju , Xiao Yao , Zhang Hualin , Yang Liguo 
Published: July 2017

Melatonin is a unique multifunctional molecule that mediates reproductive functions in animals. In this study, we investigated the effects of melatonin on bovine parthenogenetic and androgenetic embryonic development, oocyte maturation, the reactive oxygen species (ROS) levels in parthenogenetic and androgenetic embryos and cumulus—oocyte complexes (COCs) hormone secretion with melatonin supplementation at four concentrations (0, 10, 20, and 30 pmol/mL), respectively. The results showed that melatonin significantly promoted the rates of bovine parthenogenetic and androgenetic embryonic cleavage and morula and blastocysts development (P < 0.05). The rate of cleavage was higher in the androgenetic embryo than that in the parthenogenetic embryo. Compared with the parthenogenetic embryos, the androgenetic embryos had a poor developmental competence from morula to blastocyst stage. Moreover, the levels of ROS were significantly lower in the parthenogenetic and androgenetic embryoes with melatonin-treated group than that of the control group (P < 0.05). Melatonin supplemented significantly increased the maturation rate of oocytein vitro(P < 0.05). More importantly, melatonin significantly promoted the secretion of progesterone and estradiol by COCs (P < 0.05). To reveal the regulatory mechanism of melatonin on steroids synthesis, we found that steroidogenic genes (CYP11A1, CYP19A1andStAR) were upregulated, suggesting that melatonin regulated estradiol and progesterone secretion through mediating the expression of steroidogenic genes (CYP11A1,CYP19A1andStAR). In addition, MT1 and MT2 were identified in bovine early parthenogenetic and androgenetic embryos using western blot. It could be concluded that melatonin had beneficial effects on bovine oocytein vitromaturation, COC hormone secretion, early development of subsequent parthenogenetic and androgenetic embryos. It is inferred that melatonin could be used to enhance the efficiency ofin vitrodeveloped embryos.
An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations
Authors: Xie Hong-fu , Huang Ying-xue , He Lin , Yang Sai , Deng Yu-xuan , Jian Dan , Shi Wei , Li Ji 
Published: July 2017

Background
There is currently no study that has evaluated the differences in epidemiological and clinical characteristics among rosacea patients according to different facial sites.

Methods
Clinical and demographic data were obtained from 586 rosacea patients. The patients were divided into four groups based on the main sites involved with the rosacea lesions (full-face, cheeks, nose, or perioral involvement). Clinical signs were measured through self-reported, dermatologist-evaluated grading of symptoms, and physiological indicators of epidermal barrier function.

Results
There were 471 (80.4%), 49 (8.4%), 52 (8.9%), and 14 (2.4%) cases in the full-face, cheek, nasal and perioral groups, respectively. Compared with the healthy control, the full-face group had lower water content and higher transepidermal water loss (TEWL) in the cheeks, and chin; the perioral group had lower water content and higher TEWL in the chin; while the nasal group had the normal water content and TEWL. Compared with the full-face group, the nasal group had more severe phymatous changes, less severe self-reported and dermatologist-evaluated grading of symptoms. All the patients in the perioral or the nasal group had their first rosacea lesions start and remain at the chin or on the nose. In the full-face group, 55.8% of patients had their lesions start with the full face, 40.1% on the cheek, and the rest (4.1%) on the nose.

Conclusion
Significant differences in clinical features were observed among rosacea patients with lesions at four different sites. The lesion localization of each group was relatively stable and barely transferred to other locations.