bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of Guanidine Substitution on Copper Complexes as Entatic‐State Models
Authors: Hoffmann Alexander , Stanek Julia , Dicke Benjamin , Peters Laurens , Grimm‐Lebsanft Benjamin , Wetzel Alina , Jesser Anton , Bauer Matthias , Gnida Manuel , Meyer‐Klaucke Wolfram , Rübhausen Michael , Herres‐Pawlis Sonja 
Published: October 2016

AbstractInvited for the cover of this issue is the group of Sonja Herres‐Pawlis from RWTH Aachen University, Germany. The cover image shows our entatic‐state model. The research described in the article is the result of strongly collaborative work of four groups within the interdisciplinary DFG Research Unit FOR1405 (“Dynamics of Electron Transfer Processes within Transition Metal Sites in Biological and Bioinorganic Systems”).
Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease
Authors: Shohet A. , Khlebtovsky A. , Roizen N. , Roditi Y. , Djaldetti R. 
Published: October 2016

AbstractBackgroundCannabis can alleviate pain of various etiologies. This study assessed the effect of cannabis on motor symptoms and pain parameters in patients with Parkinson's disease (PD).MethodsTwenty patients with PD who were licensed to use cannabis underwent evaluation before and 30 min after cannabis consumption and again after long‐term use. Motor function was assessed with the Unified PD Rating scale (UPDRS) by two raters, one blinded. Pain was assessed with the Pain Rating Index (PRI) and Visual Analogue Scale (VAS) of the short‐form McGill Pain Questionnaire. Thermal quantitative sensory testing (QST) was performed in 18 patients. The two consecutive QST measurements were validated in 12 cannabis‐naïve patients with PD.ResultsThere was a significant decrease from baseline to 30 min after cannabis consumption in mean motor UPDRS score (38.1 ± 18 to 30.4 ± 15.6, p < 0.0001), total PRI (27 ± 13.5 to 9.7 ± 11, p = 0.001), and VAS score (6.4 ± 2.8 to 3.6 ± 3.1, p = 0.0005). Mean cold pain threshold decreased significantly in the more affected limb, but only after exclusion of two patients who consumed cannabis by vaporizer rather than smoking (19.5 ± 5.2 to 15.6 ± 8.7 °C, p = 0.02). After long‐term (median 14 weeks) exposure, mean heat pain threshold decreased significantly in the more affected limb in all treated patients (43.6 ± 3.5 to 40.9 ± 3.3 °C, p = 0.05) and in cannabis smokers (43.7 ± 3.6 to 40.3 ± 2.5 °C, p = 0.008).ConclusionsCannabis improved motor scores and pain symptoms in PD patients, together with a dissociate effect on heat and cold pain thresholds. Peripheral and central pathways are probably modulated by cannabis.SignificanceQuantitative sensory test results are significantly altered following cannabis consumption in patients with PD. Cannabis probably acts on pain in PD via peripheral and central pathways.
Time perspective as a predictor of acute postsurgical pain and coping with pain following abdominal surgery
Authors: Sobol‐Kwapinska M. , Plotek W. , Bąbel P. , Cybulski M. , Kluzik A. , Krystianc J. , Mandecki M. 
Published: October 2016

AbstractBackgroundThe aim of this study was to predict acute postsurgical pain and coping with pain following surgery based on preoperative time perspectives. Time perspective is a basic dimension of psychological time. It is a tendency to focus on a particular time area: the past, the present and the future.MethodSeventy‐six patients completed measures of time perspective and pain 24 h before abdominal surgery. During the 3 days after surgery, measures of pain and coping with pain were completed.ResultsWe performed hierarchical regression analyses to identify predictors of acute postsurgical pain and how patients cope with it. These analyses suggested that a preoperative past‐negative time perspective can be a predictor of postoperative pain level and catastrophizing after surgery.ConclusionThe findings of our study indicate the importance of time perspective, especially the past perspective, in dealing with postoperative pain.SignificanceOur research indicates that a preoperative past‐negative time perspective is a significant predictor of acute postsurgical pain intensity and the strongest predictor of pain catastrophizing.
A Cantilever‐based Biosensor for Real‐time Monitoring of Interactions between Amyloid‐β(1–40) and Membranes Comprised of Phosphatidylcholine Lipids with Different Hydrophobic Acyl Chains
Authors: Zhang Ziyang , Murakami Yuki , Taniguchi Tomoya , Sohgawa Masayuki , Yamashita Kaoru , Noda Minoru 
Published: October 2016

AbstractAccumulating evidence suggests that interaction between amyloid‐β (Aβ) and cell membrane is crucial to the pathogenesis of Alzheimer's disease (AD), and thus an increasing understanding of the impact of membrane composition on Aβ‐membrane interaction becomes essential for the mechanism elucidation of Aβ‐membrane interaction and the early diagnosis of AD. In this work, electrically neutral phosphatidylcholine (PC) as the most major class of membrane phospholipids, including 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine (DPPC), 1,2‐distearoyl‐sn‐glycero‐3‐phosphocholine (DSPC), 1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphocholine (POPC), and Aβ(1–40) as the most common amyloid protein were selected as the research subjects, and a developed cantilever‐based biosensor, on which liposomes comprised of PC lipids were immobilized, was applied to characterize in real time the interactions between Aβ(1–40) and membranes comprised of PC lipids with different hydrophobic acyl chains, and to evaluate the effect of cholesterol incorporated in membrane on Aβ‐membrane interaction during the whole process of Aβ(1–40) fibrillization. The results illustrate that the interaction between Aβ(1–40) and PC membrane can be divided into three stages, which are related to the change in molecular states of Aβ. More importantly, it is found that membranes comprised of PC lipids with shorter saturated acyl chains show higher interaction ability with Aβ(1–40), and the incorporation of cholesterol into PC bilayer can remarkably accelerate and strengthen Aβ(1–40)‐membrane interaction. These results confirm that hydrophobicity is the main driving force for the interactions between Aβ(1–40) and PC membranes. In return, the above results enlightened us to apply the current micro‐cantilever immobilized with cholesterol‐containing DPPC liposomes to challenge the detection of low‐concentration Aβ(1–40). This time 50‐nM Aβ(1–40) in aqueous solution has been effectively detected, suggesting that this proposed detection technique would contribute to Aβ detection and early diagnosis of AD in the future.
Rapid and Easy Detection of Deoxynivalenol on a Bismuth Oxide Screen‐printed Electrode
Authors: María‐Hormigos Roberto , Gismera María Jesús , Sevilla María Teresa , Rumbero Ángel , Procopio Jesús R. 
Published: October 2016

AbstractIn this work we propose a rapid method for deoxynivalenol (DON) detection based on the differential pulse voltammetric (DPV) response of this mycotoxin on a bismuth oxide modified screen‐printed electrode (SPE). In alkaline media the reduction peak of Bi2O3 is modified and an additional peak at a more negative potential is observed due to the DON presence in solution. The experimental conditions and DPV instrumental parameters have been optimized in order to get adequate responses for DON analysis on the BiOx‐SPE devices. The best results are obtained in 0.10 mol L−1 KOH using a 60 mV s−1 scan rate and 40 mV pulse amplitude. The ratio of the DON peak current to the Bi(III) reduction peak current is used for quantification purposes of this mycotoxin. Two linear response ranges (r values >0.99) with a sensitivity of 0.0019 L μg−1 (5.5×105 L mol−1) in the lower concentration range have been obtained at these measurement conditions. The reproducibility of the method is adequate, with RSD values lower than 10 % using different SPE devices for each measurement. The LOD and LOQ values (7.1 μg L−1, 2.4×10−8 mol L−1 and 24 μg L−1, 8.1×10−8 mol L−1 respectively) permit to determine DON with adequate precision and accuracy at low concentration levels. These good analytical features and the disposable and economical devices and the portable and simple instrumentation used for the measurements could make possible the implementation of this methodology for the in‐situ determination of DON.
Solvothermal Synthesis of a Molybdenum Disulfide/Reduced Porous Graphene Oxide Nanocomposite as a High‐Performance Anode Material for Lithium‐Ion Batteries
Authors: Bae Youngkuk , Seong Chae‐Yong , Yoo Suyeon , Park Seung‐Keun , Piao Yuanzhe 
Published: October 2016

AbstractAlthough molybdenum disulfide (MoS2) has a higher theoretical capacity than graphite as an anode material for lithium‐ion batteries, its intrinsically poor electrical and ionic conductivity decrease its rate properties and lithium‐storage capacity. In this work, we prepared a MoS2/reduced porous graphene oxide (rPGO) composite by the solvothermal method to complement the conductivity and to improve the lithium‐storage properties of MoS2. PGO was synthesized by a convenient, low‐costing, and mass‐producible nitric acid treatment method. Owing to its large surface area and porous structure, the MoS2/rPGO sample exhibited improved capacity and cyclic stability over other MoS2/reduced graphene oxide (rGO) and MoS2 nanoparticle samples. After 100 cycles, the MoS2/rPGO electrode showed an improved capacity of 932 mAh g−1, whereas the capacity of the MoS2/rGO electrode was 395 mAh g−1 at a current density of 200 mA g−1.
Improvement of Lithium‐Ion Battery Performance by Two‐Layered Slot–Die Coating Operation
Authors: Liu Darjen , Chen Li‐Chun , Liu Ta‐Jo , Chu Wen‐Bing , Tiu Carlos 
Published: October 2016

AbstractThe cathode and anode electrodes in lithium‐ion batteries typically contain a significant proportion of particles and binders. During the electrode drying process, high temperature will lead to the binder migration phenomenon. Uneven particle/binder distribution can cause poor adhesion between coating and substrate, disruption of conductive paths, and decrease in electrode performance. In this study, a two‐layered cathode was designed by using separate compositions of slurry ingredients in each layer, as produced by means of a simultaneous multilayer coating method. The two‐layered cathode with the top layer containing less binder than the bottom layer yielded a better particle/binder distribution in the final structure under high‐temperature drying. A battery made with the two‐layered cathode appeared to give a better overall performance.
Passive dosing of triclosan in multigeneration tests with copepods – stable exposure concentrations and effects at the low μg/L range
Authors: Ribbenstedt Anton , Mustajärvi Lukas , Breitholtz Magnus , Gorokhova Elena , Mayer Philipp , Sobek Anna 
Published: October 2016

Abstract

Ecotoxicity testing is a crucial component of chemical risk assessment. Still, due to methodological difficulties related to controlling exposure concentrations over time, data on long-term effects of organic chemicals at low concentrations are limited. The aim of the present study was, therefore, to test the applicability of passive dosing to maintain stable concentrations of the organochlorine bacteriocide triclosan in the water phase during a 6-wk multigeneration population development test with the harpacticoid copepod Nitocra spinipes. Triclosan was loaded into silicone (1000 mg), which was used as passive dosing phase in the exposure vials. The distribution ratio for triclosan between silicone and water (Dsilicone-water) was 10466 ± 1927. A population development test was conducted at 3 concentration levels of triclosan that were measured to be 3 μg/L to 5 μg/L, 7 μg/L to 11 μg/L and 16 μg/L to 26 μg/L. The results demonstrate that passive dosing is applicable for long-term ecotoxicity testing of organic chemicals, including during significant growth of the test organism population. Shifts in the demographic structure of the population during exposure suggest the most severe effects were exerted on juvenile development. Progressively lower development index values in the populations exposed to increasing triclosan concentrations suggest developmental retardation. The results further stress the need for chronic exposure during ecotoxicity testing in chemical risk assessment because even the most sensitive endpoint was not significant until after 7 d of exposure. Environ Toxicol Chem 2017;36:1254–1260. © 2016 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
School egress data: comparing the configuration and validation of five egress modelling tools
Authors: Cuesta Arturo , Ronchi Enrico , Gwynne Steven M. V. , Kinsey Michael J. , Hunt Aoife L. E. , Alvear Daniel 
Published: October 2016

SummaryData were collected between 2011 and 2014 from five evacuations involving the same school buildings located in Spain. Children from 6 to 16 years of age were observed during the evacuation exercises. Background information was collected on key factors deemed to influence evacuation performance: a description of the geometry, the population involved, the procedures employed and the organization of the drills conducted. Using live observations and video footage of these drills, evacuation data were collected, focusing on the pre‐evacuation times, the routes employed, the travel speeds adopted and the arrival times. These data informed a range of a posteriori simulations, conducted by using four computer models (buildingEXODUS, MassMotion, Pathfinder and STEPS) and the Society of Fire Protection Engineering hydraulic model (i.e. Society of Fire Protection Engineering hand calculations). Comparisons were drawn between the models' output and against the observed outcome for one of the trials to determine the accuracy of the model predictions given that they were configured by using the initial conditions for a specific evacuation. The purpose of this work is to (1) provide insight into the configuration of these models for equivalent scenarios, (2) examine any variation in the simulated conditions given equivalent initial conditions, and (3) provide suggestions on how to perform validation studies for multiple evacuation models. Copyright © 2016 John Wiley & Sons, Ltd.
Is it possible to assess the allergenicity of mixtures based on in chemico methods? Preliminary results on common fragrance aldehydes
Authors: Lang Matthieu , Giménez‐Arnau Elena , Lepoittevin Jean‐Pierre 
Published: October 2016

AbstractMost perfume compositions and cosmetics contain mixtures of fragrance ingredients, synthetic or extracted from natural sources. Many of these are known to be weak or moderate allergens when tested individually. However, fragrances are one of the most common causes of allergic contact dermatitis to consumer products, ranking second after nickel. As consumers are exposed to mixtures of ingredients when using products that contain perfume, it was suggested that mixtures could enhance induction and elicitation of skin allergy to fragrances. Prediction of skin sensitization to chemicals is crucial for the cosmetics industry. Nowadays, methods to assess skin sensitization hazard replacing the use of animals have been developed and validated for the testing of pure substances. However, there is practically no experience with testing of mixtures. Here we evaluated in a very preliminary approach, and from a chemical reactivity perspective, if the validated DPRA, hapten‐peptide reactivity based assay, could be used at a first sight to evaluate the chemical reactivity of mixtures. Two simple binary combinations of fragrance aldehydes were studied, hydroxycitronellal‐citral and citral‐cinnamaldehyde. Their reactivity towards DPRA peptides was compared with that of the single constituents. In general, the chemical described as the most potent sensitizer was driving the reactivity in the mixtures. Therefore, it could be hypothesized that the DPRA would estimate the mixture chemical reactivity similar to that of the stronger sensitizer component. This will be reinforced by conditions described for the DPRA where the tested chemical or mixture of chemicals will be added in large excess to the peptides. Copyright © 2016 John Wiley & Sons, Ltd.
Literature review and meta‐analysis of risk factors for delayed post‐traumatic stress disorder in older adults after a fall
Authors: Bloch Frédéric 
Published: October 2016

ObjectiveTo test the hypothesis that post‐traumatic stress disorder (PTSD) can appear after a fall and try to identify predictive factors for its development in older fallers.MethodsSystematic literature review and meta‐analyses of studies on PTSD post fall in older subjects.ResultsOne hundred seventy‐seven indexed articles were identified, of which three had complete data on PTSD post fall in older subjects. Only the odds ratio of the association between history of fall and occurrence of PTSD was significant (odds ratio = 2.79 (95% CI, 1.03–7.53).ConclusionThe trend in our results, even though limited, reveals two groups of subjects: frail subjects that are at risk of developing PTSD and subjects who seem to be resistant to its development. A clear description of these two groups may help us identify the population at risk for delayed PTSD who could then benefit from dedicated treatment. Copyright © 2016 John Wiley & Sons, Ltd.
The Costs of Exhibiting Organizational Citizenship Behavior
Authors: Deery Stephen , Rayton Bruce , Walsh Janet , Kinnie Nicholas 
Published: October 2016

AbstractOrganizational citizenship behavior (OCB) has been associated with positive organizational outcomes and with higher managerial ratings of employee performance. However, concerns have been raised about the possible personal costs of performing such activities. This paper examines the relationship between OCB and emotional exhaustion and work‐family conflict and explores the moderating role of job performance in shaping those relationships. In a time‐lagged field study of customer‐contact center employees the research found that one particular dimension of OCB—conscientiousness—was associated with higher emotional exhaustion and with work‐family conflict. The study also revealed that conscientious employees who performed their in‐role job responsibilities at a high level experienced greater emotional exhaustion and work‐family conflict than conscientious employees who performed their in‐role job responsibilities at a low level. Our findings suggest that organizational pressures to increase the level at which both discretionary and formal role obligations are performed can carry negative consequences for employees. © 2016 Wiley Periodicals, Inc.
Euro Effect on Trade in Final, Intermediate and Capital Goods
Authors: Martínez‐Zarzoso Inmaculada , Johannsen Florian 
Published: October 2016

AbstractThe aim of this paper is to provide fresh evidence on the effect of the adoption of the euro on exports of different types of goods. The novelty with respect to previous research is threefold. First, disaggregated trade data are used to allow for heterogeneous effects for final intermediate and capital goods. Second, we distinguish between the euro effect on the extensive and the intensive margins of trade. Finally, we estimate the impact of the Euro adoption controlling for exchange rate volatility, exchange rate movements and EU membership. This allows us to disentangle the effect of a common currency beyond the elimination of trade barriers and of any variation in the exchange rate. The main results indicate that the impact of the Euro on trade values (intensive margin) is around 9% for intermediates, 7% for final goods and it is negative for capital goods. Interestingly, the Euro effects on the extensive margin of trade are found to be negative and significant for the three types of goods, pointing to increasing specialization. Copyright © 2016 John Wiley & Sons, Ltd.
Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma
Authors: Honda Akiko , Sawahara Takahiro , Hayashi Tomohiro , Tsuji Kenshi , Fukushima Wataru , Oishi Mizuki , Kitamura Gaku , Kudo Hitomi , Ito Sho , Yoshida Seiichi , Ichinose Takamichi , Ueda Kayo , Takano Hirohisa 
Published: October 2016

AbstractEpidemiologic studies have revealed that Asian sand dust particles (ASDs) can affect respiratory and immune health represented by asthma. Factors responsible for the exacerbation of asthma remain unclear. The fungus Bjerkandera adusta (B.ad) and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) have been identified in ASDs collected from the atmosphere when an ASD event occurred. We investigated the effects of B.ad and BaP related to ASDs on respiratory and immune systems. Bone marrow‐derived antigen‐presenting cells (APCs) and splenocytes from atopic prone NC/Nga mice and human airway epithelial cells were exposed to the B.ad or to BaP in the presence and absence of heated‐ASDs (H‐ASDs). B.ad and BaP in both the presence and absence of H‐ASDs increased the expression of cell surface molecules on APCs. H‐ASDs alone slightly activated APCs. The expressions induced by B.ad were higher than those induced by BaP in the presence and absence of H‐ASDs. There were no remarkable effects on the activation of splenocytes or the proinflammatory responses in airway epithelial cells. These results suggest that B.ad rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by the activation of the immune system via APCs. Copyright © 2016 John Wiley & Sons, Ltd.
Raman spectroscopic identification of Mycobacterium tuberculosis
Authors: Stöckel Stephan , Meisel Susann , Lorenz Björn , Kloß Sandra , Henk Sandra , Dees Stefan , Richter Elvira , Andres Sönke , Merker Matthias , Labugger Ines , Rösch Petra , Popp Jürgen 
Published: October 2016

In this study, Raman microspectroscopy has been utilized to identify mycobacteria to the species level. Because of the slow growth of mycobacteria, the per se cultivation‐independent Raman microspectroscopy emerges as a perfect tool for a rapid on‐the‐spot mycobacterial diagnostic test. Special focus was laid upon the identification of Mycobacterium tuberculosis complex (MTC) strains, as the main causative agent of pulmonary tuberculosis worldwide, and the differentiation between pathogenic and commensal nontuberculous mycobacteria (NTM). Overall the proposed model considers 26 different mycobacteria species as well as antibiotic susceptible and resistant strains. More than 8800 Raman spectra of single bacterial cells constituted a spectral library, which was the foundation for a two‐level classification system including three support vector machines. Our model allowed the discrimination of MTC samples in an independent validation dataset with an accuracy of 94% and could serve as a basis to further improve Raman microscopy as a first‐line diagnostic point‐of‐care tool for the confirmation of tuberculosis disease.
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