bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic CD34+ hematopoietic stem cell boost for prolonged severe cytopenias following CAR T-cell therapy in B-cell acute lymphoblastic leukemia. A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC)
Authors: Molinos-Quintana Águeda , Martinez-Cibrian Nuria , Alonso-Saladrigues Anna , Galán Victor , Bailén Rebeca , Buendía-López Susana , Fuentes Carolina , Kwon Mi , González-Vincent Marta , de Soto Concepción Pérez , Gonzalez Berta , rives s , Pérez-Hurtado José María , Ortiz-Maldonado Valentin , Pérez-Simón José A 
Published: September 2024

Abstract

Hematological toxicity is the most common long-term adverse event after CAR T-cell therapy. Severe cytopenias not resolving over time may result in life-threatening infection or bleeding and the best clinical practice to treat this persisting cytopenias after CAR-T is not well established. Eleven heavily pretreated patients with B-ALL and prolonged cytopenia after CAR-T therapy were successfully treated with an allogeneic CD34+ hematopoietic stem cell (HSC) boost. The median time from CAR T-cell infusion to donor CD34+ HSC boost was 2.8 months and median CD34+ selected dose was 4 x106/kg of recipient weight. The median time to hematological recovery in all three cell lineages was 20 days (range 12–60). One-year event free survival was significantly different for patients relapsing before 6 months post-transplantation (14.3%) vs after 6 months post-transplantation (75%). With a median follow-up after HSC boost of 12 months, overall survival (OS) at 24 months was 31.2% with a median OS of 21 months (95% CI 6.2–35.7). All causes of death were related to disease relapse. In conclusion, we confirm that allogeneic CD34+ HSC boost is an effective and safe therapeutic option that should be considered in patients with primary poor graft function persisting beyond 60–90 days after CAR-T
Graft-Repositioning Technique Using Infusion and Small Bubbles During Descemet’s Membrane Endothelial Keratoplasty
Authors: Shimizu Toshiki , Oyakawa Itaru , Tomida Daisuke , Yokogawa HIdeaki , Kobayashi Akira , Yamagami Satoru , Hayashi Takahiko 
Published: September 2024

Abstract

Background: Descemet's membrane endothelial keratoplasty (DMEK) is a highly effective procedure for corneal endothelial dysfunction; however, once a DMEK graft is deployed, repositioning can be challenging. Therefore, this study aimed to evaluate the efficacy of a technique that utilizes infusion and small air bubbles to reposition a misaligned deployed graft.
Methods: This retrospective interventional case series enrolled patients who underwent DMEK between January 2022 and July 2023, including cases where the DMEK graft was attached and unfolded in off-center positions". Experienced surgeons performed DMEK by inserting an infusion cannula and positioning a small bubble in the anterior chamber after the graft unfolded off-center. The eye was tilted in a deviated direction, and the cornea was massaged from the corneal limbus to the center using a 27-gauge blunt needle. Before and after DMEK, we measured the best spectacle-corrected visual acuity (BSCVA), central corneal thickness (CCT), and endothelial cell density (ECD). Additionally, we monitored the incidence of postoperative complications.
Results: Six eyes of six patients were included in this study. Postoperatively, the overall BSCVA and CCT of the eyes improved (P<0.001). However, one eye developed recurrent uveitis and required a sub-Tenon’s capsule triamcinolone acetonide injection. No eyes required re-bubbling, and no instances of primary graft failure were observed.
Conclusion: The described technique enables the safe and feasible repositioning and unfolding of the DMEK graft.
Newly Diagnosed Essential Thrombocythemia Leading to Cardiogenic Shock: A Case Report
Authors: Patel Ravi , DeRon Nathan 
Published: September 2024

Abstract

Background
Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by uninhibited platelet production. It can present with vasomotor symptoms, and less commonly, severe thrombotic events such as myocardial infarction. ST-segment elevation myocardial infarction (STEMI) secondary to the hypercoagulable state in ET is a diagnostic challenge as the complication is rare, especially outside the typical demographics affected by ET such as the female and elderly populations.
Case Presentation:
A 32-year-old male presented to the emergency department with chest pain. On admission, the patient’s platelet count was 1,244,000 platelets/µL. A clinical diagnosis of STEMI was made by electrocardiogram, and the patient underwent emergent cardiac catheterization with placement of an Impella. Angiographic findings revealed a 100% flush occlusion of the ostial left anterior descending (LAD) artery and 80% occlusion of the ostial left circumflex artery (LCA) with thrombus. Successful percutaneous coronary intervention of the ostial LAD with a drug-eluting stent and balloon angioplasty of the ostial LCA was performed with full restoration of blood flow. He was initiated on aspirin and ticagrelor. The patient’s condition was complicated by cardiogenic shock for which the Impella remained in place. Subsequent transthoracic echocardiogram showed a left ventricular ejection fraction of 20–25%. Due to the patient’s markedly elevated platelet count, there was concern for possible underlying ET. A PCR assay on peripheral blood isolated from the patient was positive for a JAK2 V617F mutation. The patient was slowly weaned off the Impella over five days, and once he was hemodynamically and clinically stable, he was initiated on hydroxyurea and discharged with a wearable cardioverter defibrillator. Cardiac rehabilitation was planned.
Conclusions
This case illustrates the potential for severe thrombotic complications such as STEMI due to ET. Severe thrombotic complications are less common manifestations of ET in general, particularly in young males. Recognition and diagnosis of ET are critical for the institution of appropriate therapy and prevention of STEMI and cardiogenic shock among other complications.
Application of Multi-Source Remote Sensing Fusion for Identifying Smoke Fugitive Channels in the Sulabulak Fire Area, Urumqi, China
Authors: Yang Zhicheng , Zeng Qiang 
Published: September 2024

Abstract

Underground coal fires are a pervasive global environmental issue, especially in coal-rich regions, causing significant environmental damage, safety hazards, and economic losses. These fires release smoke containing carbon dioxide and other harmful gases, exacerbating climate change. This study presents a novel comprehensive analysis method using multi-source remote sensing technology to detect smoke fugitive channels caused by coal fires. We utilized 29 Landsat-8 satellite images of the Sulabulak fire area in China to retrieve vegetation coverage (FVC) and land surface temperature (LST), identifying sparse vegetation and high-temperature anomaly areas. Additionally, 135 dual-polarized Sentinel-1A images were used to obtain surface deformation through SBAS-InSAR and PS-InSAR techniques. The integration of these datasets, validated by field survey data, revealed a high degree of overlap between the identified smoke fugitive channels and subsidence areas. Our results demonstrate an annual increase in sparse vegetation areas, high-temperature anomalies, and ground subsidence, indicating intensified coal fire combustion and expanding smoke fugitive channels. This method's effectiveness in identifying coal fire areas underscores its potential for enhancing coal fire monitoring and management, contributing to more accurate carbon emission estimates and improved mitigation strategies.
Indigenous knowledge of browse species and nutritional quality of dominant Indigenous browses species in the Kavango West Region of Namibia
Authors: Hamukwaya Rosa N. , Charamba Vonai , Kahumba Absalom , Shipandeni Maria N. T , Mupangwa Johnfisher 
Published: September 2024

Abstract

Livestock production is crucial to the livelihoods of rural Namibians but highly constrained by feed shortages due to climate change and bush encroachment. The study investigated the grazing and feeding practices and indigenous knowledge of browsable and non-browsable species by interviewing 30 small-scale farmers in the Kavango West Region. It assessed the nutritive value for the three most commonly identified browsable species. The study observed that livestock relies on communal rangeland, roadside, and riverside grazing, with supplements from crop residues during the dry seasons. However, most farmers experience feed shortages mainly in the dry season, which results in decreased livestock productivity. Farmers are knowledgeable on browsable and non-browsable woody species in their locality, but most do not harvest pods, leaves and twigs to supplement their animals in the dry season, citing labour shortage, and they are not aware that the bush species resources can be harvested and be used during seasons when feed resources are scarce. The nutritive value analysis indicated that there is a need for strategic supplementation of the browsable species for them to be effectively utilised as livestock feed, thus farmers must be capacitated on when and how to utilise these species when herbaceous pasture grasses and legumes are senescent as well as how to harvest forage alongside rivers and roads for stall feeding to avoid accidents. Our findings will be important for policy formulation in trying to come up with better ways of mitigating the consequences of climate change.
Lumbar lordosis correction loss following lateral lumbar interbody fusion for adult spinal deformity
Authors: Lee Ki Young , Lee Jung-Hee , Jung Cheol-Hyun , Han Gil , Kim Jae-Ho , Ko Jae-Hyeock 
Published: September 2024

Abstract

Although multilevel lateral lumbar interbody fusion (LLIF) with posterior column osteotomy (PCO) can achieve the similar effect as pedicle subtraction osteotomy (PSO) and the incidence of rod fracture (RF) is low, the risk of RF still remains. We noticed that correction loss often precedes RFs. To evaluate the correction loss after surgery in adult spinal deformity (ASD) patients, we retrospectively analyzed the CT scans of 89 ASD patients (average 71.5 years) with a minimum 2-year follow up. The intervertebral disc (IVD) angle from T12 to S1 were measured, comparing those with a decrease of 5° or more in lumbar lordosis (LL) at 2 years (correction loss group, n = 23) to those without a decrease (non-correction loss group, n = 63). The IVD angles in the L2-3, L4-5, L5-S1 showed significant differences immediately after surgery and at 1 year after surgery. RF incidence was 25.8% (23/89 cases). LL correction loss more than 5° was associated with RF (p < .001, OR = 7.28). The LL correction loss showed a distributed pattern with a decrease in each IVD angles. LL correction loss was closely associated with RF and can be seen as a danger signal of RF, so additional support should be considered to prevent correction loss and RF.
Incidence, Associated Risk Factors, and Outcomes of Postoperative Anxiety in Elderly: a retrospective study
Authors: Guo Hao , Li Li-Heng , Lv Xiao-Hong , Xiao Fei , Xie Yu-Bo 
Published: September 2024

Abstract

Background
Research on postoperative anxiety (POA), especially in elderly, is limited. The relevance of POA for patients’ outcomes is unknown. We aimed to ascertain the incidence, identify potential risk factors and investigate the immediate outcomes of POA.
Methods
This retrospective cohort study analyzed elderly who underwent surgery in our hospital between May 1, 2020, and March 31, 2021. Perioperative anxiety was evaluated with the Generalized Anxiety Disorder Questionnaire-7. A multivariable logistic regression was used to assess associations between perioperative data and occurrence of POA.
Results
A total of 308 patients were analyzed. POA was recorded in 160 patients within 7 days after surgery (51.9%). The incidence of POA was associated with worsened postoperative sleep quality (PSQ) and pain. Preoperative anxiety (OR, 3.60; 95% CI, 1.76–7.40) and preoperative sleep disturbance (OR, 3.34; 95% CI, 1.82–6.13) were identified as independent risk factors of POA. Patients who developed POA exhibited significantly higher 24 h pain VAS scores and worsen PSQ scores on postoperative day 1, 2 and 3. Anxiety at 30 and 90 days after surgery was significantly increased compared with those without POA.
Conclusion
Our study indicates that POA is prevalent and associated with immediate postoperative outcomes.
Development and validation of a functional ex vivo paclitaxel and eribulin sensitivity assay for breast cancer, the REMIT assay
Authors: Gent Dik van , Komar Zofia , Verkaik Nicole , Dahmani Ahmed , Montaudon Elodie , Kanaar Roland , Houtsmuller Adriaan , Jager Agnes , Marangoni Elisabetta 
Published: September 2024

Abstract

Breast cancer is the most common cancer amongst women worldwide, however clinically validated chemotherapy response biomarkers that can accurately predict treatment response in patients are largely lacking. Therefore, in this study, functional paclitaxel and eribulin ex vivo sensitivity assays were developed. Patient derived xenograft (PDX) models were used to compare the ex vivo predicted treatment outcome with the sensitivity of mice in vivo. We validated the previously developed sensitivity assay for paclitaxel, which is based on the ratio between replicating (EdU) and mitotic (phospho-Histone H3; pH3) cells as a proxy for blocked mitosis. The assay showed 90% correlation between the ex vivo and in vivo response to paclitaxel treatment in the PDX models. We propose the term REMIT (REplication MITosis) assay and show that it is also a suitable test to predict eribulin sensitivity. The reproducibility of the REMIT assay for paclitaxel and eribulin was determined to be 80% and 83%, respectively. These results justify further clinical validation of the REMIT assay in breast cancer patients.
Analysis of Factors Influencing Auditory Temporal Resolution Based on Mandarin
Authors: Wang Yan , Hu Yuanjia , Pan Yunyun , Wang Yaowen , Liu Yuhe 
Published: September 2024

Abstract

Objective:
This study examines the correlation between the temporal resolution of the auditory system and speech recognition in noise based on Mandarin. It also explores the impact of various factors on the temporal resolution abilities in the elderly.
Methods:
A total of 170 participants were included in this research. The control group consisted of 30 young individuals with normal hearing thresholds, while the experimental group comprised 30 elderly individuals aged 60 and above with mild to moderately severe hearing loss and 20 elderly individuals who wore hearing aids. Tests conducted included the Gaps in Noise (GIN) test for auditory temporal resolution and the Mandarin Quick Speech-in-Noise test (M-QuickSIN), from which Gap Detection Threshold (GDT) scores and SNR loss scores were derived. Statistical analysis was performed using SPSS 25.0.
Results:
The differences between GDT and M-QuickSIN scores were statistically significant (p < 0.05) in the moderate and moderately severe hearing loss and hearing aid wearing elderly groups. Significant statistical differences in GDT were also observed between the normal hearing young group and the normal hearing elderly group, as well as between the normal hearing elderly group and the elderly with moderate to moderately severe hearing loss (P < 0.05). Notably, significant differences in GDT before and after the use of hearing aids were observed in the same elderly individuals (P < 0.001).
Conclusion:
Increasing age, degree of hearing loss, and M-QuickSIN scores significantly influence GDT outcomes. Long-term use of hearing aids decreases GDT and enhances speech recognition capabilities in noise. When subjects are unable to perform speech audiometry clinically, the GIN test should be considered for diagnostic reference.
Clinical Utilization and Infrastructure of Radiation Therapy in Korea in 2020 and 2021
Authors: Kang Jin-Kyu , Jang Won Il , Kim Mi-Sook , Kim Eunji , Kim Hee Jin , Yoon Jaesun , Shin Young-Joo , Kim Jongwoo , Kim Kum-Bae 
Published: September 2024

Abstract

Background
Radiation therapy (RT) is a critical component in the treatment of cancer, alongside surgery and chemotherapy. Monitoring RT utilization (RTU) rates and infrastructure of RT trends provides valuable information on cancer care. This study aimed to evaluate the clinical status of RT, including the RTU rate and infrastructure of RT in Korea in 2020 and 2021.
Methods
Patient data for individuals undergoing RT in 2020 and 2021 were sourced from the Health Insurance Review and Assessment Service (HIRA). Through the data from the HIRA, we assessed the following aspects: the total number of patients who received RT in 2020 and 2021, the RTU rate for patients with cancer, the RTU rate by cancer diagnosis, the number of RT patients by age, the RT rate by region, the rate of hypofractionated RT for breast cancer, and RT ratio by specific RT modality. The RT infrastructure and human resources were analyzed using data from the Korea Institute of Radiological and Medical Sciences Dosimetry Lab and a nationwide survey.
Results
In 2020 and 2021, 90,351 and 97,840 patients, respectively, underwent RT in Korea, indicating an annual increase in treatment frequency. The RTU rates for patients with cancer were 32.8% in 2020 and 31.7% in 2021. Breast, lung, prostate, colorectal, and liver cancers were the most commonly treated types, with prostate cancer showing the most rapid growth in RTU rate among cancer types. The adoption of intensity-modulated RT is swiftly replacing conventional RT, and there continues to be a concentration of RT services in Seoul. Hypofractionated RT for breast cancer saw a steady increase, with rates rising from 23.5% in 2017 to 38.6% in 2020. As the total number of patients receiving RT increased, the number of RT centers, RT machines, and human resources in radiation oncology departments nationwide also steadily increased.
Conclusion
The study’s data present the clinical status of RT in Korea during 2020 and 2021. The number of patients undergoing RT in Korea shows ongoing growth, accompanied by corresponding expansions in RT infrastructure.
Outcomes with Allogeneic Hematopoietic Stem Cell Transplantation in Therapy Related Myeloid Neoplasms: A Systematic Review and Meta-Analysis
Authors: Shahzad Moazzam , Amin Muhammad Kashif , Khalid Muhammad Fareed , Kasaeian Amir , Oskouie Iman , Basharat Ahmad , Butt Atif , Zaidi Maheen , Anwar Iqra , Mushtaq Muhammad 
Published: September 2024

Abstract

In this meta-analysis and systematic review, 7785 patients from 33 original studies reporting outcomes of therapy- related myeloid neoplasms (t-MN) including therapy-related acute myeloid leukemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS) were included. The survival data were retrieved from Kaplan-Meier (KM) curves to calculate the overall survival (OS) and disease-free survival (DFS) probabilities. 67.3% (n = 5241) of the patients had t-AML. 26.5% (n = 2076) had t-MDS, and 6% had a mixed presentation (n = 468). The age of the patients ranged from 2 to 89 years and 61.7% were females. The pooled median OS was 16.9 months (95% CI: 13.7–21.1) and the estimated mean OS was 46.0 months (95% CI: 42.1–49.6). The pooled median DFS was 8.8 months (95% CI: 7.4–11.2) and mean DFS was 37.8 months (95% CI: 33.4–41.9). The pooled proportion of acute graft versus host disease (aGvHD) was 34% (95% CI: 0.35–0.45, I2: 91.71%, p < 0.0001). Relapse of the myeloid neoplasm was the most common cause of mortality, followed by infections, relapse of the underlying disease, and GvHD. Despite complications, allo-HCT is still the curative treatment option with better outcomes compared to conventional chemotherapy in t-MN. Timely transplants in carefully selected patients with post-HCT interventions could improve outcomes.
Influence of Processing Parameters on Microstructure and Electrical Properties of ZnO-Based Varistor Ceramics
Authors: Hassan Muhammad , Hussain Muddassar , Nigah Azaz , Ali Muhammad , Amin Muhammad Abid , Arslan Muhammad 
Published: September 2024

Abstract

ZnO-based are the most common amongst varistors, used for surge protection of electrical equipment. The effect of sintering parameters, such as sintering temperature, ramp rate and soaking time on microstructure development and V-I characteristics of ZnO-based varistor ceramics doped with various oxide additives (Bi2O3, MnO3, Co2O3.etc) was studied. The results from the experiments exhibit that phase concentration, microstructure and electrical properties can be varied upon change in above said parameters. Soaking time at the sintering temperature has a little effect on microstructure and properties, however, higher sintering temperatures for prolong times widely affect phase concentrations, especially the Bi2O3-rich phases. Varistor voltage exhibited a reverse relation with sintering temperature while leakage current was reduced remarkably on slowing down the ramp rate at temperatures higher than 950 ̊C. Best results were obtained on slower heating rates and lower soaking times with sintering temperature of 1220 ̊C.
A Diversified Integrated Model for Seasonal Product Demand Prediction
Authors: Bin Liu , Hao Ding , Qiaoyun Yun 
Published: September 2024

Abstract

Product demand forecasting is the core link of an intelligent supply chain. The article discusses the demand characteristics of seasonal fast-moving consumer goods and presents a diversified stacked regression model (RXOEL-X) that combines linear and multi-machine learning models. This model utilizes a model stacking strategy and adopts the ElasticNet model, combined with L1 and L2 regularization to handle complex relationships in the data and prevent overfitting. Empirical evaluation using real data from leading beverage companies demonstrates the model's superiority over other time series forecasting techniques in demand forecasting for smart supply chains.
Quality optimization of liquid silicon lenses based on sequential approximation optimization and radial basis function networks
Authors: Chang Hanjui , Lu Shuzhou , Sun Yue , Lan Yuntao 
Published: September 2024

Abstract

In order to obtain competitive advantages in terms of product cost and quality, this study proposes a multi-objective optimization method based on sequential approximation optimization and radial basis function networks. In the optimization process, the radial basis function network replaces the finite element reanalysis and allows the construction of an approximate functional relationship between quality and process conditions. In this study, injection molding of objects was simulated and analyzed while varying the filling time, melt temperature, mold temperature, curing pressure, and curing time schemes to better understand the aspects affecting the optimization process. Using the automobile optical liquid silicone lens as an example, the Pareto boundary is used to determine the residual stress and volume shrinkage, as well as the deviation function and radial basis function network. Because numerical simulations are time-consuming, the radial basis function sequential approximation optimization method is applied. The product had the highest quality when the filling time was 1.57s, the melt temperature was 27.18°C, the mold temperature was 150°C, the curing time was 20.02s, and the curing pressure was 28.79 MPa, according to numerical results. Experiments were carried out to test the efficacy of the proposed approach. Nondestructive analysis is used to determine the target values (residual stress and volume shrinkage). Because nondestructive testing does not damage materials, workpieces, or buildings, the inspection rate of items can be quite high following nondestructive testing. Furthermore, numerical and experimental data demonstrate that the technique effectively reduces residual stress and volume shrinkage.