bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxytocin Analogues for the Oral Treatment of Abdominal Pain
Authors: Kremsmayr Thomas , Schober Gudrun , Kaltenböck Matthias , Hoare Bradley L. , Brierley Stuart M. , Muttenthaler Markus 
Published: October 2024

AbstractAbdominal pain presents an onerous reality for millions of people affected by gastrointestinal disorders such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The oxytocin receptor (OTR) has emerged as a new analgesic drug target with OTR expression upregulated on colon‐innervating nociceptors in chronic visceral hypersensitivity states, accessible via luminal delivery. However, the low gastrointestinal stability of OTR's endogenous peptide ligand oxytocin (OT) is a bottleneck for therapeutic development. Here, we report the development of potent and fully gut‐stable OT analogues, laying the foundation for a new area of oral gut‐specific peptide therapeutics. Ligand optimisation guided by structure‐gut‐stability‐activity relationships yielded highly stable analogues (t1/2>24 h, compared to t1/2<10 min of OT in intestinal fluid) equipotent to OT (~3 nM) and with enhanced OTR selectivity. Intra‐colonic administration of the lead ligand significantly reduced colonic mechanical hypersensitivity in a concentration‐dependent manner in a mouse model of chronic abdominal pain. Moreover, oral administration of the lead ligand also displayed significant analgesia in this abdominal pain mouse model. The generated ligands and employed strategies could pave the way to a new class of oral gut‐specific peptides to study and combat chronic gastrointestinal disorders, an area with substantial unmet medical needs.
Preparation of high‐performance polymer sensitive membrane for rapid and sensitive detection of ammonium ions in aqueous solution
Authors: Li Tianbing , Lu Xiaozhen , Chen Haonan , Cai Junlong , Gao Hongbo , Zhu Xuewu , Yu Jian , Li Guangchao 
Published: October 2024

AbstractPolymer sensitive membrane is a key component of the ammonium ion selective electrode (ISE). Developing a high‐performance ammonium ion polymer sensitive membrane can promote production and application of the electrode, reducing costs and simplifying ammonia nitrogen detection. In this study, we modified the surface of the ammonium ion selective membrane and synthesized a low‐cost antimicrobial material by anchoring the broad‐spectrum antimicrobial agent, silver nanoparticles (AgNPs), on the surface of two‐dimensional transition metal car‐ bides (Ti3C2Tx MXene). This material can be used as a carrier to avoid the release of AgNPs. The inorganic antimicrobial agent AgNPs@MXene was adhered to the surface of the ammonium ion‐selective membrane by polydopamine, forming an antimicrobial coating. The modified ammonium ion‐selective electrode had a rapid response time of 12 s, with an average response time of 12.4 s. After repeated tests, a lower detection limit of 5.89 × 10−7 (10−6.23) mol/L was achieved in ammonium chloride solution. These results indicate that the ammonium ion monitoring electrode we prepared can effectively monitor ammonia nitrogen concentration in sewage and wastewater over a long period of time. This also enhances the service life of the ammonium ISE and reduces maintenance costs for the sensor.
Synthesis and Optical Properties of Organic‐Inorganic Hybrid [(18‐Crown‐6)K][MoOCl4(H2O)]
Authors: Ghosh Animesh , Saikia Sajid , Molokeev Maxim S. , Nag Angshuman 
Published: October 2024

AbstractCrown ether anchored organic‐inorganic hybrid halides have been recently reported as interesting luminescent materials in the visible region of electromagnetic spectrum. Is it possible to develop such crown ether anchored hybrid materials for near infrared emission? Motivated by this question, we designed a new hybrid material, namely, [(18‐Crown‐6)K][MoOCl4(H2O)]. 18‐Crown‐6 ether bound with K+ form the cationic part [(18‐Crown‐6)K]+. The K+ of [(18‐Crown‐6)K]+ electrostatically interacts with Cl− of the anionic part [MoOCl4(H2O)]−, forming the hybrid crystal [(18‐Crown‐6)K][MoOCl4(H2O)]. It crystallizes in orthorhombic crystal system with Pnma space group. The Mo(V) possesses one d‐electron (d1) in
point group symmetry in the [MoOCl4(H2O)]− polyhedra. This electronic configuration leads to multiple spin‐allowed
transitions along with a ligand to metal charge transfer (LMCT) resulting into multiple optical absorption bands in the near UV‐visible‐near infrared (NIR) region. The lowest energy
transition via 2E (
,
)/2E (
)
2B2 (
) leads to NIR PL with peak at 952 nm, but with a poor intensity at room temperature.
Regulating and Unraveling Electrochemical Behavior of Hierarchically‐Densifying Mesoporous Apocynum Carbon for High performance Supercapacitor
Authors: Tong Qijun , Zhang Zhihao , Luo Qitian , Gu Kai , Yang Weiqing 
Published: October 2024

AbstractThe commercial carbon‐based supercapacitor with high power ability (~5 kW kg−1) is still unable to fulfill the superhigh power requirement of specific power‐type equipments (>20 kW kg−1), such as rail transit facilities, electromagnetic and laser equipment. To unravel the structure‐activity relationship and electrochemical behavior of power‐type densifying carbon is a key to overcome the contradiction of the suitable mesoporous ratio and highly‐densifying features toward the superhigh power requirement. Here, we built the hierarchically‐densifying mesoporous apocynum carbon (HDMC) with optimized mesoporous ratio by hierarchical activation method. More importantly, both the isothermal desorption/adsorption and high‐pressure mercury intrusion porosimetry methods were employed to synergistically uncover the microscopic surface carbon network stacking mechanism and the macroscopic carbon skeleton densification assembly mechanism. The highly‐densifying skeleton features and high mesoporous ratio properties were proved to be co‐existed in HDMC, which is in favour of rapidly ion/electron transferring toward electrochemically‐improving power behavior of HDMC. A combination of high tap density (0.387 g cm−3) and ideal microporous‐mesoporous system (23.1 % proportion of mesoporous) have taken this HDMC to provide a super‐high power density (33.5 kW kg−1) and a high volume power density (9.37 kW L−1) for HDMC‐based supercapacitor, more than those of commercial YP‐50F (14.9 kW kg−1 @ 4.63 kW L−1). Therefore, this work provides a synergistic strategy to incorporate the properties of mesoporous and densifying, and reveals its electrochemical behavior toward the further application of power‐type supercapacitors.
Application of Noninvasive Imaging Techniques for High Energy Density Lithium Metal Rechargeable Batteries
Authors: Dutta Arghya , Matsuda Shoichi 
Published: October 2024

AbstractLithium metal batteries (LMBs) have the potential to exceed the energy density of current lithium‐ion batteries. Achieving this requires a thick positive electrode, a thin Li metal negative electrode, and minimal electrolyte‐loading. Despite their promise, high energy density LMBs with high‐loading positive electrodes, thin Li, and low electrolytes face significant challenges. A key issue is the high reactivity of Li metal with nonaqueous electrolytes, leading to the consumption of both during each cycle. This reaction causes insulating Li compounds to accumulate, increases electrode porosity and thickness, depletes the electrolyte, raises cell impedance, and reduces capacity. Therefore, understanding the interphase evolution of the Li metal electrode is crucial to addressing cell failure. While various ex situ and in situ techniques have been used to study these interphases, they often involve non‐practical cell configurations and sample‐damaging preparation processes. In this regard, noninvasive methods like X‐ray and neutron‐based imaging are beneficial as they do not damage samples, can be used both in situ and ex situ, employ practical cell configurations, and enable long‐term data collection. This review explores recent advancements in X‐ray and neutron‐based techniques for characterizing high‐energy LMBs, emphasizing their potential to improve understanding of interphasial dynamics and advance robust high‐energy‐density batteries.
Model‐Driven Manufacturing of High‐Energy‐Density Batteries: A Review
Authors: Maksimovna Vakhrusheva Daria , Xu Jun 
Published: October 2024

AbstractThe rapid advancement in energy storage technologies, particularly high‐energy density batteries, is pivotal for diverse applications ranging from portable electronics to electric vehicles and grid storage. This review paper provides a comprehensive analysis of the recent progress in model‐driven manufacturing approaches for high‐energy‐density batteries, highlighting the integration of computational models and simulations with experimental manufacturing processes to optimize performance, reliability, safety, and cost‐effectiveness. We systematically examine various modeling techniques, including electrochemical, thermal, and mechanical models, and their roles in elucidating the complex interplay of materials, design, and manufacturing parameters. The review also discusses the challenges and opportunities in scaling up these model‐driven approaches, addressing key issues such as model validation, parameter sensitivity, and the integration of machine learning and artificial intelligence for predictive modeling, process optimization, and quality assurance. By synthesizing current research findings and industry practices, this paper aims to outline a roadmap for future developments in model‐driven manufacturing of high‐energy density batteries, emphasizing the need for interdisciplinary collaboration and innovation to meet the increasing demands for energy storage solutions.
Using self‐management strategies to improve toothbrushing for adults in supported community living
Authors: Miak Gatwech , Zane Thomas , Kuhn Robin M. , Koegel Lynn 
Published: October 2024

AbstractHygiene is an important area related to personal health and socialization. Regular toothbrushing can prevent painful procedures related to tooth decay and gum disease and reduce bad breath and plaque that may interfere with social and professional acceptance. Unfortunately, many individuals with disabilities do not engage in regular and thorough preventative dental hygiene, placing them at risk for oral disease. Using a multiple baseline design, three participants who independently brushed their teeth but did not brush frequently or thoroughly were taught to self‐evaluate and record using a self‐management (SM) checklist. The findings of this study suggest that SM may be a helpful method for improving the frequency and quality of toothbrushing. Outcomes regarding supporting individuals to achieve maximal independence in these essential life skills are discussed.
One‐Pot Synthesis of Sustainable Fluorescent Nanomaterials via Microwave Irradiation as a Probe for the Determination of Metformin in Pure and Pharmaceutical Dosage Forms: Greenness and Whiteness Metrics
Authors: Abou El‐Alamin Maha M. , Mohamed Dina A. , Farag Amir Shaaban 
Published: October 2024

ABSTRACTA rapid, green and sensitive technique for the determination of metformin determination was developed based on the direct fluorescence enhancement of carbon dots (CDs) induced by the cited drug. The water‐soluble CDs were prepared via a one‐pot synthesis from avocado peels using domestic microwave. The prepared CDs exhibited strong fluorescence at 405 nm after excitation at 320 nm with a quantum yield of 51%. The fluorescence of CDs was enhanced linearly by increasing the concentration of metformin within the range 0.5–25 μg/mL with limit of detection 0.087 μg/mL and limit of quantification 0.263 μg/mL. The designed probe was proved to be selective toward metformin in the presence of other drugs such as vildagliptin and alogliptin and also in the presence of excipients in the pharmaceutical dosage form. The suggested and reported methods were compared with the help of the whiteness and greenness tools, specifically the white analytical chemistry and analytical greenness metric tools, for assessing hazardous solvents and reagents used.
Development of a rapid and robust hydrop interaction liquid chromatography tandem mass spectrometry method for the detection of 13 endogenous amino acids as well as trimethylamine oxide in serum and tissues of the mice
Authors: Hu Didi , Liu Xudong , Yao Ying , Wei Shijie , Ji Hongyan , Yang Yang , Chen Jing , Chen Linwei 
Published: October 2024

AbstractThis work aimed to establish an HILIC‐MS/MS method to simultaneously determine the levels of 13 endogenous amino acids and trimethylamine oxide in the biological samples from the mice. Electrospray ion source was used for the analysis of mass spectrometry. The 20 min separation was applied in a Dikma Inspire Hilic column (2.1 × 100.0 mm, 3 μM). Positive ion mode under an MRM model gave a satisfying response value. The limits of quantitation were evaluated by accuracy from −12.59% to 7.89% and precision from 1.77% to 14.00% as well as acceptable interday and intraday precision, matrix effect, recovery, and stability. Later, the assay was successfully used to measure the concentrations of the determinands in the biological samples. Individual and tissue distribution differences for these metabolites were observable. The amino acids had a consistent highest content in the spleens, while the lowest levels were found in the livers. Alanine was the most abundant amino acid in the serum, and taurine kept the highest content in all of the tissues. Trimethylamine oxide remained low level, especially in the liver samples.
Sacrificial strategy towards the formation of vascular‐like networks in volumetric tissue constructs
Authors: Buckley Christian , Ibrahim Rana , Giordano Felicia , Xu Nuo , Sems Brandon , Wang Hongjun 
Published: October 2024

AbstractThe fields of tissue engineering and regenerative medicine have made astounding progress in recent years, evidenced by cutting‐edge 4D printing technologies, precise gene editing tools, and sustained long‐term functionality of engineered tissue grafts. Despite these fantastic feats, the clinical success of tissue‐engineered constructs so far remains limited to only those relatively simple types of tissues such as thin bilayer skin equivalents or avascular cartilage. On the other hand, volumetric tissues (larger than a few millimeters in all dimensions), which are highly desirable for clinical utility, suffer from poor oxygen supply due to limited dimensional diffusion. Notably, large, complex tissues typically require a vascular network to supply the growing cells with nutrients for metabolic demands to prolong viability and support tissue formation. In recognition, extensive efforts have been made to create vascular‐like networks in order to facilitate mass exchange through volumetric scaffolds. This review underlines the urgent need for continued research to create more complex and functional vascular networks, which is crucial for generating viable volumetric tissues, and highlights the recent advances in sacrificial template‐enabled formation of vascular‐like networks.
Does EMA implementation promote green innovation? The mediation effects of both cross‐functional coopetition and supplier co‐creation
Authors: Xu Yizhen , Cheah Jun‐Hwa , Hair Joseph F. , Liu Yide 
Published: October 2024

AbstractThe call for green innovation necessitates the creation of an ecosystem that is friendly to the environment. Certain environmental regulations and standards are put in place to foster this type of innovation. However, there are many literature debates on the impact of guidelines and management controls on green innovation. Drawing on both the resource‐based view (RBV) and dynamic capability theory (DCT), this study investigates the impact of environmental management accounting (EMA) implementation on green process and product innovation, considering the mediating effects of cross‐functional coopetition and supplier co‐creation. Multi‐wave surveys were conducted across 799 Chinese companies. The results show that EMA implementation has a positive effect on both cross‐functional coopetition and co‐creation. In addition, cross‐functional coopetition serves to mediate the relationship between EMA implementation and both green process and product innovation. However, it should be noted that supplier co‐creation only serves to mediate the relationship between EMA implementation and green process innovation, rather than green product innovation. Overall, this research adds to the RBV literature by offering a fresh perspective on the role of cross‐functional coopetition in situations where resources are shared and conflicts occur simultaneously. Furthermore, the study enhances our understanding of DCT by examining the role of supplier co‐creation. This research delves into how companies balance resource availability with environmental adaptability, striking a balance between replication and renewal.
Innovative optical imaging strategies for monitoring immunotherapy in the tumor microenvironments
Authors: Um‐e‐Kalsoom  , Wang Shiqi , Qu Junle , Liu Liwei 
Published: October 2024

AbstractBackgroundThe tumor microenvironment (TME) plays a critical role in cancer progression and response to immunotherapy. Immunotherapy targeting the immune system has emerged as a promising treatment modality, but challenges in understanding the TME limit its efficacy. Optical imaging strategies offer noninvasive, real‐time insights into the interactions between immune cells and the TME.ObjectiveThis review assesses the progress of optical imaging technologies in monitoring immunotherapy within the TME and explores their potential applications in clinical trials and personalized cancer treatment.MethodsThis is a comprehensive literature review based on the advances in optical imaging modalities including fluorescence imaging (FLI), bioluminescence imaging (BLI), and photoacoustic imaging (PAI). These modalities were analyzed for their capacity to provide high‐resolution, real‐time imaging of immune cell dynamics, tumor vasculature, and other critical components of the TME.ResultsOptical imaging techniques have shown significant potential in tracking immune cell infiltration, assessing immune checkpoint inhibitors, and visualizing drug delivery within the TME. Technologies like FLI and BLI are pivotal in tracking immune responses in preclinical models, while PAI provides functional imaging with deeper tissue penetration. The integration of these modalities with immunotherapy holds promise for improving treatment monitoring and outcomes.ConclusionOptical imaging is a powerful tool for understanding the complexities of the TME and optimizing immunotherapy. Further advancements in imaging technologies, combined with nanomaterial‐based approaches, could pave the way for enhanced diagnostic accuracy and therapeutic efficacy in cancer treatment.
Network Analyses Applied to the Dimensions of Cancer‐Related Fatigue in Women With Breast Cancer
Authors: Baussard Louise , Ernst Marie , Diep Anh , Jerusalem Guy , Vanhaudenhuyse Audrey , Marie Nolwenn , Bragard Isabelle , Faymonville Marie‐Elisabeth , Gosseries Olivia , Grégoire Charlotte 
Published: October 2024

ABSTRACTBackgroundUnderstanding cancer symptom cluster through network analyses is a new approach in oncology, revealing interconnected and influential relationships among reported symptoms. We aimed to assess these relationships using network analysis in posttreatment breast cancer patients, focusing on the five dimensions of cancer‐related fatigue (CRF), and on other common difficulties encountered by oncological patients (i.e., pain, anxiety, depression, sleep difficulties, cognitive impairments, and emotion regulation and mental adaptation difficulties).MethodThis study involved a complementary analysis of data from two interventional studies. Participants completed questionnaires before and after the intervention, with baseline scores being used in this article. Partial correlation network analysis modeled the relationships between symptoms in five distinct networks, each of them including one specific dimension of CRF. The core symptom in each network was identified based on the highest centrality indices.ResultsDepression emerged as the core symptom in all networks, strongly associated with all fatigue dimensions (partial correlations ranging from 0.183 to 0.269) except mental fatigue. These findings indicate robust connections between symptoms, as variations in depression scores directly or indirectly influence fatigue and other symptoms within the cluster.ConclusionOur results support the multidimensional aspect of CRF, and its links with other common symptoms. To effectively reduce patient CRF, interventions should address not only fatigue but also the closely related symptoms from the cluster, such as depression, given its centrality in the cluster.Trial Registration: ClinicalTrials.gov (NCT03144154 and NCT04873661). Retrospectively registered on May 1, 2017 and April 29, 2021, respectively.
A New Approach to Ultra‐Low Anterior Resection—Intersphincteric Dissection With Total Hiatal Ligament Excision for Very Low Rectal Cancer Located in the Posterior Wall of the Rectum: A More Satisfactory Technique for Local Recurrence Control
Authors: Li Shoufeng , Wang Ye , Cai Huajun , Pan Zhen , Liu Xing , Zhuang Jinfu , Guan Guoxian 
Published: October 2024

ABSTRACTBackgroundThe hiatal ligament, as the anatomical landmark for the completion of total mesorectal excision (TME) for ultra‐low rectal cancer, represents a continuation of the longitudinal muscle of the rectum. It receives vascular supply from the median sacral artery and contains lymphatic vessels. In cases where ultra‐low rectal cancer is located in the posterior rectal wall, the hiatal ligament may theoretically serve as an anatomical region susceptible to direct tumor cell spread or distant metastasis.ObjectiveTo evaluate the effect of circumferential tumor location (CTL) on postoperative survival of low rectal cancer and to determine the effect of total hiatal ligament excision (THLE) on the prognosis of patients with posterior rectal cancer.MethodsPatients with ultra‐low rectal cancer who underwent laparoscopic surgery between March 2014 and October 2021 were enrolled in this study. Propensity score matching (PSM) analysis was used to compare the clinicopathological characteristics and prognosis of patients in the posterior group and the non‐posterior group. Prognostic factors were identified using COX regression. PSM analysis was also used in the posterior tumor subgroup to compare the clinicopathological characteristics and prognosis of patients in the hiatal ligament traditional transection (HLTT) and THLE groups.ResultsAfter PSM, OS, and DFS were comparable between the posterior and non‐posterior groups. Similarly, no difference was noted in the local recurrence rate between the two groups (p = 0.23). The prognosis of ultra‐low rectal cancer was not affected by CTL. However, the local recurrence rate was significantly lower in the THLE group compared with the HLTT group (p = 0.023). Multivariate analysis of the posterior group identified CRM, TNM stage III, and HLTT as independent risk factors for local recurrence‐free survival.ConclusionsCTL is not a prognostic risk factor for low rectal cancer. In posterior wall tumors, THLE significantly reduces the local recurrence rate for low rectal cancer.