bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Should Be Done? Pragmatic Constructivist Ethics and the Responsibility to Protect
Authors: Ralph Jason 
Published: December 2017

AbstractIn this paper I examine what constructivist approaches to IR tell us about how states should act when confronted by atrocity crimes in the context of a politically pluralist international society. Building on the work of theorists who responded to Richard Price and Christian Reus-Smit's call to substantiate the constructivist's claim to explain “moral progress,” and to better inform normative assessments, I claim that the constructivist emphasis on historical and social contingency does not rule out ethical standpoints, suggesting instead a “pragmatic” ethic. Norms are hypotheses rather than absolute values. The task of the pragmatic constructivist is not to establish beyond doubt the normativity of a norm—the task is to test the norm for how well its “meaning-in-use” supports action that ameliorates lived social problems. Pragmatic constructivists can commit to the Responsibility to Protect (R2P) as an idea that might reconcile various communities of normative practice and ameliorate vulnerability without upsetting international order. To the extent particular practices (e.g., prevention) have proven (and continue to prove) useful in doing this, pragmatic constructivists can equate the institutionalization of those practices with normative progress. However, R2P is a “complex” norm. It recognizes that knowledge of how to respond to ongoing atrocity is context specific and cannot therefore be fixed. The task of the pragmatic constructivist here is to assess the practical judgment of those that claim to speak for the norm by weighing the consequences of acting out their prescription in the specific context of a particular crisis. I test the meanings of R2P in use during the Syria crisis from 2011 to 2012. R2P was problematic to the extent certain meanings reinforced policy ends (e.g., protection through political/criminal accountability) that were impractical and pursued at the expense of non-ideal but realizable goals (e.g., protection through peace/aid).
An overview onLeishmania(Mundinia)enriettii: biology, immunopathology, LRV and extracellular vesicles during the host–parasite interaction
Authors: Paranaiba Larissa F. , Pinheiro Lucélia J. , Macedo Diego H. , Menezes-Neto Armando , Torrecilhas Ana C. , Tafuri Wagner L. , Soares Rodrigo P. 
Published: December 2017

AbstractOne of theLeishmaniaspecies known to be non-infective to humans isLeishmania(Mundinia)enriettiiwhose vertebrate host is the guinea pigCavia porcellus.It is a good model for cutaneous leishmaniasis, chemotherapeutic and molecular studies. In the last years, an increased interest has emerged concerning theL. (Mundinia) subgenus after the finding ofLeishmania(M.)macropodumin Australia and with the description of other new/putative species such asL. (M.) martiniquensisand ‘L.(M.)siamensis’. This review focused on histopathology, glycoconjugates and innate immunity. The presence ofLeishmaniaRNA virus and shedding of extracellular vesicles by the parasite were also evaluated.
Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice
Authors: Souza Ana Carolina Moreira , Mosqueira Vanessa Carla Furtado , Silveira Ana Paula Amariz , Antunes Lidiane Rodrigues , Richard Sylvain , Guimarães Homero Nogueira , Grabe-Guimarães Andrea 
Published: December 2017

AbstractArtemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria. The purposes of this work were to study free-ATM and ATM-loaded poly-ε-caprolactone nanocapules (ATM-NC) cardiotoxicity and oral efficacy on Plasmodium berghei-infected mice. ATM-NC was obtained by interfacial polymer deposition and ATM was associated with polymeric NC oily core. For cardiotoxicity evaluation, male black C57BL6 uninfected or P. berghei-infected mice received, by oral route twice daily/4 days, vehicle (sorbitol/carboxymethylcellulose), blank-NC, free-ATM or ATM-NC at doses 40, 80 or 120 mg kg−1. Electrocardiogram (ECG) lead II signal was obtained before and after treatment. For ATM efficacy evaluation, female P. berghei-infected mice were treated the same way. ATM-NC improved antimalarial in vivo efficacy and reduced mice mortality. Free-ATM induced significantly QT and QTc intervals prolongation. ATM-NC (120 mg kg−1) given to uninfected mice reduced QT and QTc intervals prolongation 34 and 30%, respectively, compared with free-ATM. ATM-NC given to infected mice also reduced QT and QTc intervals prolongation, 28 and 27%, respectively. For the first time, the study showed a nanocarrier reducing cardiotoxicity of ATM given by oral route and it was more effective against P. berghei than free-ATM as monotherapy.
Children's comprehension of contrastive connectives
Authors: SPENADER Jennifer 
Published: December 2017

ABSTRACTProduction studies show connective acquisition by age 3;0, but comprehension studies show errors until 9;0 or older. To further investigate this gap, two comprehension tasks were carried out with 78 Dutch children between the ages of 7;0 and 10;1, testing contrastive maar ‘but’ and causal want ‘because’ connectives for comparison. An existing context choice task and a task that tested children's ability to interpret pronouns dependent on the connective were used. Children did well on the context choice task for want ‘because’, but performed far below chance with maar ‘but’. In the pronoun interpretation task the youngest children performed at or near chance with both connectives, but show gradual improvement with age. Task complexity may partially explain the results but in general, they are consistent with previous experiments showing contrastive connective comprehension is acquired very late compared to their correct production. Further, the pronoun interpretation task may give a more accurate picture of understanding.
Territorial Disputes and Their Resolution in the Recent Jurisprudence of the International Court of Justice
Authors: THIRLWAY HUGH 
Published: December 2017

AbstractThe workload of the International Court of Justice in recent years has increasingly featured cases of disputes classified either as ‘territorial disputes’ or as ‘boundary disputes’, or otherwise involving the Court in considerations of the law relating to acquisition or transmission of territory, or to the creation, location and effect of territorial frontiers. The present survey analyzes the contributions to international law of the Court's decisions in these recent cases. Matters examined include the significance of the terms ‘boundary dispute’ or ‘territorial dispute’; the definition of what constitutes sovereign territory; titles andeffectivitésas bases for territorial claims; decolonization and theuti possidetis juris; use of natural features or of straight lines as boundaries; and relations across a frontier once established.
The evaluation of arterial stiffness of essential hypertension and white coat hypertension in children: a case-control study
Authors: Tokgöz Semiha Terlemez , Yılmaz Dilek , Tokgöz Yavuz , Çelik Bülent , Bulut Yasin 
Published: December 2017

AbstractBackgroundThe aim of this study was to determine and compare cardiovascular risks by assessing arterial stiffness in children with essential hypertension and white coat hypertension.MethodsPaediatric patients followed up with essential hypertension and white coat hypertension diagnoses and with no established end organ damage were involved in the study. Arterial stiffness in children included in the study was evaluated and compared by using the oscillometric device (Mobil-O-Graph) method.ResultsA total of 62 essential hypertension (34 male, 28 female), 38 white coat hypertension (21 male, 17 female), and 60 healthy controls (33 male, 27 female) were assessed in the present study. Pulse wave velocity of the essential hypertension, white coat hypertension, and control group was, respectively, as follows: 5.3±0.6 (m/s), 5.1±0.4 (m/s), 4.3±0.4 (m/s) (p<0.001); augmentation index outcomes were, respectively, determined as follows: 21.3±6.5, 19.3±6.4, 16.0±0.3 (p<0.001). Pulse wave velocity and augmentation index values of children with essential hypertension and white coat hypertension were found to be higher compared with the control group. This level was identified as correlated with the duration of hypertension in both patient groups (p<0.01).ConclusionArterial stiffness in children with essential hypertension and white coat hypertension was impaired compared with healthy children. This finding has made us think that white coat hypertension is not an innocent clinical situation. This information should be taken into consideration in the follow-up and treatment approaches of the patients.
The Influence of Exposure to Natural Disasters on Depression and PTSD Symptoms among Firefighters
Authors: Pennington Michelle L. , Carpenter Thomas P. , Synett Samantha J. , Torres Victoria A. , Teague Jennifer , Morissette Sandra B. , Knight Jeffrey , Kamholz Barbara W. , Keane Terence M. , Zimering Rose T. , Gulliver Suzy B. 
Published: December 2017

AbstractIntroductionFirefighters represent an important population for understanding the consequences of exposure to potentially traumatic stressors.Hypothesis/ProblemThe researchers were interested in the effects of pre-employment disaster exposure on firefighter recruits’ depression and posttraumatic stress disorder (PTSD) symptoms during the first three years of fire service and hypothesized that: (1) disaster-exposed firefighters would have greater depression and PTSD symptoms than non-exposed overall; and (2) depression and PTSD symptoms would worsen over years in fire service in exposed firefighters, but not in their unexposed counterparts.MethodsIn a baseline interview, 35 male firefighter recruits from seven US cities reported lifetime exposure to natural disaster. These disaster-exposed male firefighter recruits were matched on age, city, and education with non-exposed recruits.ResultsA generalized linear mixed model revealed a significant exposure×time interaction (ecoef =1.04; P<.001), such that depression symptoms increased with time for those with pre-employment disaster exposure only. This pattern persisted after controlling for social support from colleagues (ecoefficient=1.05; P<.001), social support from families (ecoefficient=1.04; P=.001), and on-the-job trauma exposure (coefficient=0.06; ecoefficient=1.11; P<.001). Posttraumatic stress disorder symptoms did not vary significantly between exposure groups at baseline (P=.61).ConclusionDepression symptoms increased with time for those with pre-employment disaster exposure only, even after controlling for social support. Posttraumatic stress disorder symptoms did not vary between exposure groups.PenningtonML, CarpenterTP, SynettSJ, TorresVA, TeagueJ, MorissetteSB, KnightJ, KamholzBW, KeaneTM, ZimeringRT, GulliverSB. The influence of exposure to natural disasters on depression and PTSD symptoms among firefighters. Prehosp Disaster Med. 2018;33(1):102–108.
Hospital-Confirmed Acute Myocardial Infarction: Prehospital Identification Using the Medical Priority Dispatch System
Authors: Clawson Jeff J. , Gardett Isabel , Scott Greg , Fivaz Conrad , Barron Tracey , Broadbent Meghan , Olola Christopher 
Published: December 2017

AbstractIntroductionEarly recognition of an acute myocardial infarction (AMI) can increase the patient’s likelihood of survival. As the first point of contact for patients accessing medical care through emergency services, emergency medical dispatchers (EMDs) represent the earliest potential identification point for AMIs. The objective of the study was to determine how AMI cases were coded and prioritized at the dispatch point, and also to describe the distribution of these cases by patient age and gender.Hypothesis/ProblemNo studies currently exist that describe the EMD’s ability to correctly triage AMIs into Advanced Life Support (ALS) response tiers.MethodsThe retrospective descriptive study utilized data from three sources: emergency medical dispatch, Emergency Medical Services (EMS), and emergency departments (EDs)/hospitals. The primary outcome measure was the distributions of AMI cases, as categorized by Chief Complaint Protocol, dispatch priority code and level, and patient age and gender. The EMS and ED/hospital data came from the Utah Department of Health (UDoH), Salt Lake City, Utah. Dispatch data came from two emergency communication centers covering the entirety of Salt Lake City and Salt Lake County, Utah.ResultsOverall, 89.9% of all the AMIs (n=606) were coded in one of the three highest dispatch priority levels, all of which call for ALS response (called CHARLIE, DELTA, and ECHO in the studied system). The percentage of AMIs significantly increased for patients aged 35 years and older, and varied significantly by gender, dispatch level, and chief complaint. A total of 85.7% of all deaths occurred among patients aged 55 years and older, and 88.9% of the deaths were handled in the ALS-recommended priority levels.ConclusionAcute myocardial infarctions may present as a variety of clinical symptoms, and the study findings demonstrated that more than one-half were identified as having chief complaints of Chest Pain or Breathing Problems at the dispatch point, followed by Sick Person and Unconscious/Fainting. The 35-year age cutoff for assignment to higher priority levels is strongly supported. The Falls and Sick Person Protocols offer opportunities to capture atypical AMI presentations.ClawsonJJ, GardettI, ScottG, FivazC, BarronT, BroadbentM, OlolaC. Hospital-confirmed acute myocardial infarction: prehospital identification using the Medical Priority Dispatch System. Prehosp Disaster Med. 2018;33(1):29–35.
Changes in job strain and subsequent weight gain: a longitudinal study, based on the Danish Nurse Cohort
Authors: Vesterlund Gitte Kingo , Keller Amélie Cléo , Heitmann Berit Lilienthal 
Published: December 2017

AbstractObjectiveObesity as well as job strain is increasing, and job strain might contribute to weight gain. The objective of the current study was to examine associations between longitudinal alterations in the components of job strain and subsequent weight gain.DesignThe study was designed as a prospective cohort study with three questionnaire surveys enabling measurement of job-strain alterations over 6 years and subsequent measurements of weight gain after further 10 years of follow-up. ANCOVA and trend analyses were conducted. Job demands were measured as job busyness and speed, and control as amount of influence.SettingEmployed nurses in Denmark.SubjectsWe included a sub-sample of 6188 female nurses from the Danish Nurse Cohort, which consisted of the nurses who participated in surveys in 1993, 1999 and 2009.ResultsA linear trend in weight gain was seen in nurses who were often busy in 1999 between those who were rarely v. sometimes v. often busy in 1993 (P=0·03), with the largest weight gain in individuals with sustained high busyness in both years. Loss of influence between 1993 and 1999 was associated with larger subsequent weight gain than sustained high influence (P=0·003) or sustained low influence (P=0·02). For speed, no associations were found.ConclusionsBusyness, speed and influence differed in their relationship to subsequent weight gain. A decrease in job influence and a sustained burden of busyness were most strongly related to subsequent weight gain. Focus on job strain reduction and healthy diet is essential for public health.
Disordered eating in Sami and non-Sami Norwegian populations: the SAMINOR 2 Clinical Survey
Authors: Kvaløy Kirsti , Melhus Marita , Silviken Anne , Brustad Magritt , Sørlie Tore , Broderstad Ann Ragnhild 
Published: December 2017

AbstractObjectiveThe present study aimed to investigate disordered eating (DE) among Sami compared with non-Sami residing in northern Norway.DesignIn a cross-sectional design, stratified by sex and ethnicity, associations were tested between DE (Eating Disturbance Scale; EDS-5) and age, education level, BMI category, anxiety and depression, physical activity and consumption of snacks.SettingThe SAMINOR 2 Clinical Survey (2012–2014) based on the population of ten municipalities in northern Norway.SubjectsAdults aged 40–69 years; 1811 Sami (844 male, 967 female) compared with 2578 non-Sami (1180 male, 1398 female) individuals.ResultsNo overall significant ethnic difference in DE was identified, although comfort eating was reported more often by Sami individuals (P=0·01). Regardless of ethnicity and sex, symptoms of anxiety and depression were associated with DE (P<0·001). Furthermore, DE was more common at lower age and higher BMI values. Education levels were protectively associated with DE among Sami men (P=0·01). DE was associated (OR, 95% CI) with low physical activity in men in general and in non-Sami women (Sami men: 2·4, 1·4, 4·0; non-Sami men: 2·2, 1·4, 3·6; non-Sami women: 1·8, 1·2, 2·9) and so was the consumption of snacks (Sami men: 2·6, 1·3, 5·0; non-Sami men: 1·9, 1·1, 3·1; non-Sami women: 2·1, 1·3, 3·4).ConclusionsThere were no significant differences regarding overall DE comparing Sami with non-Sami, although Sami more often reported comfort eating. There were significant sex and ethnic differences related to DE and physical activity, snacking and education level.
Effect of dietary habits on the risk of metabolic syndrome: Yazd Healthy Heart Project
Authors: Sarebanhassanabadi Mohammadtaghi , Mirhosseini Seyed Jalil , Mirzaei Masoud , Namayandeh Seyedeh Mahdieh , Soltani Mohammad Hossein , Pakseresht Mohammadreza , Pedarzadeh Ali , Baramesipour Zahra , Faraji Reza , Salehi-Abargouei Amin 
Published: December 2017

AbstractObjectiveMetabolic syndrome (MetS) refers to a group of risk factors that increase the risk of cardiovascular mortality and morbidity. Dietary habits are among the most important risk factors for MetS. The current study aimed at assessing the effect of dietary habits on the risk of MetS in a 10-year follow-up study in central Iran.DesignCohort study.SettingYazd, Iran.SubjectsParticipants aged 20–74 years without any history of MetS, who were originally recruited for Yazd Healthy Heart Project (YHHP) during 2005–2006, were revisited during 2015–2016. At phase I of YHHP, demographic data, anthropometric measurements, five components of MetS, biochemical tests and dietary habits were evaluated; and the same data were collected in phase II.ResultsA total of 1092 participants were eligible to be included in the present study. After follow-up, the 10-year cumulative incidence of MetS was 56·1 %. After adjustment for potential confounders, increased risk of MetS (hazard ratio; 95 % CI) was found in those who did not try to control their body weight (1·57; 1·06, 2·35), did not usually eat salad (1·91; 1·22, 3·00) and added salt to their food (1·57, 1·06, 2·33). These associations were stronger in men than in the total population after subgroup analysis, but were not present in women.ConclusionsDietary habits affect the risk of MetS in the Iranian population. Lifestyle interventions are needed to improve dietary habits to reduce the risk of MetS. Future studies are highly recommended to confirm our results in other populations.
Overcrowding: Nobody's fault? When some struggle to survive waiting for everyone to take responsibility
Authors: Ballon Vincent 
Published: December 2017

AbstractVisiting an overcrowded prison is a journey into the private life of each person deprived of his or her freedom, into the community of the detainees and of the staff working in such a place. Using the senses of sight, hearing, smell and touch, combined with empathy and time for observation, helps ICRC delegates to explore vulnerabilities, discover how detainees and staff cope, and grasp the intricate complexity of such a prison system. Beyond what is left of human dignity in these places of detention, when coping mechanisms become survival mechanisms, the suffering shows that overcrowding is wrong. It follows that if overcrowding is “nobody's fault”, it is the responsibility of every individual and every institution of the criminal justice system to create solutions.
Multiscale Invasive Plant Monitoring: Experiences from the Greater Everglades Restoration Area
Authors: Rodgers LeRoy , Pernas Tony , Redwine Jed , Shamblin Brooke , Bruscia Shea 
Published: December 2017

AbstractObtaining spatially explicit, cost-effective, and management-relevant data on invasive plant distributions across large natural areas presents considerable challenges. This is especially true when multiple monitoring objectives exist, because the utility of different monitoring methodologies varies with scale, logistical considerations, and information needs. The Florida Everglades is a vast wetland landscape with widespread invasive plant infestations and multiple management jurisdictions. A multi-agency team Working Group conducted a workshop in 2013 to explore opportunities to enhance the performance of a regional weed control program. Among the most important developments occurring at this meeting was the recognition that relevant management questions are scale-dependent. This led the team to define multiple monitoring objectives. Essential for conveying the success of the weed management program is quantifying large-scale patterns of change, as are quantifying fine-scale patterns informing control activities, defining mechanisms of spread, recognizing accelerating rates of spread, and detecting patterns of occupancy immediately before management intervention. The group’s deliberation resulted in the emergence of a multiscale monitoring program utilizing several distinct monitoring protocols, including systematic landscape-level reconnaissance, a sample-based spatially stratified monitoring system, detailed inventories in planned treatment areas, and a set of methods focused solely on early detection and rapid response. Here we provide an overview of the Everglades multiscale invasive plant monitoring program, highlight benefits and challenges of each program component, and discuss how this program has improved regional invasive plant management.
Ethnic differences in metabolite signatures and type 2 diabetes: a nested case–control analysis among people of South Asian, African and European origin
Authors: van Valkengoed Irene G. M. , Argmann Carmen , Ghauharali-van der Vlugt Karen , Aerts Johannes M. F. G. , Brewster Lizzy M. , Peters R. J. G. , Vaz Frédéric M. , Houtkooper Riekelt H. 
Published: December 2017

AbstractAccumulation of metabolites may mark or contribute to the development of type 2 diabetes mellitus (T2D), but there is a lack of data from ethnic groups at high risk. We examined sphingolipids, acylcarnitines and amino acids, and their association with T2D in a nested case–control study among 54 South Asian Surinamese, 54 African Surinamese and 44 Dutch in the Netherlands. Plasma metabolites were determined at baseline (2001–2003), and cumulative prevalence and incidence of T2D at follow-up (2011–2012). Weighted linear and logistic regression analyses were used to study associations. The mean level of most sphingolipids was lower, and amino-acid levels higher, in the Surinamese groups than among the Dutch. Surinamese individuals had higher mono- and polyunsaturated acylcarnitines and lower plasma levels of saturated acylcarnitine species than the Dutch. Several sphingolipids and amino acids were associated with T2D. Although only the shorter acylcarnitines seemed associated with prevalent T2D, we found an association of all acylcarnitines (except C0, C18 and C18:2) with incident T2D. Further analyses suggested a potentially different association of several metabolites across ethnic groups. Extension and confirmation of these findings may improve the understanding of ethnic differences and contribute to early detection of increased individual risk.