bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models
Authors: Liu Shuang , Hasegawa Hitoshi , Takemasa Erika , Suzuki Yasuyuki , Oka Keizou , Kiyoi Takeshi , Takeda Hiroyuki , Ogasawara Tomio , Sawasaki Tatsuya , Yasukawa Masaki , Maeyama Kazutaka 
Published: July 2017

Abstract
Store-operated Ca2+ release–activated Ca2+ (CRAC) channels are involved in the pathogenesis of rheumatoid arthritis (RA) and have been studied as therapeutic targets in the management of RA. We investigated the efficacy and safety of CRAC inhibitors, including a neutralizing Ab (hCRACM1-IgG) and YM-58483, in the treatment of RA. Patient-derived T cell and B cell activity was suppressed by hCRACM1-IgG as well as YM-58483. Systemically constant, s.c. infused CRAC inhibitors showed anti-inflammatory activity in a human-NOD/SCID xenograft RA model as well as protective effects against the destruction of cartilage and bone. hCRACM1-IgG appeared to be safe for systemic application, whereas YM-58483 showed hepatic and renal toxicity in xenograft mice. Treatment with both CRAC inhibitors also caused hyperglycemia in xenograft mice. These results indicate the potential of hCRACM1-IgG and YM-58483 as anti-immunological agents for the treatment of RA. However, some safety issues should be addressed and application methods should be optimized prior to their clinical use.
Chilaiditi’s sign or syndrome? Diagnostic question in two patients with concurrent cardiovascular diseases
Authors: Hountis Panagiotis , Chounti Maria 
Published: July 2017

<p>Chilaiditi’s sign is the asymptomatic, usually incidental radiographic finding, in which a part of the intestine is located between the liver and the diaphragm. The term Chilaiditi syndrome is referred to cases with symptomatic hepatodiaphragmatic interposition. Chilaiditi’s syndrome is usually associated with abdominal or lower thoracic symptoms. We present here the cases of two patients that were admitted with predominantly thoracic atypical pain. During cardiac work up, it was found that there was a concurrent heart disease for which both patients were managed. Although both patients were treated for the heart disease, a full conservative treatment was implemented, having in mind that Chilaiditi’s syndrome instead of sign could be responsible for the symptoms. Patients’ course was uneventful and they are regularly followed up. </p><p><strong> </strong></p>
Editorial
Authors: Pinto Adilson Luiz , Schmitz Rafaela Paula , Muriel-Torrado Enrique 
Published: July 2017

Prezados leitores.Com muita satisfação publicamos o primeiro número de 2017 (v. 22, n. 48) da Encontros Bibli: Revista Eletrônica de Biblioteconomia e Ciência da Informação.Para esta edição trazemos na portada uma fotografia dos pilares de sustentação do Viaduto do Museu no Parque Güell, concebido por Antoni Gaudí, representando aqui a estrutura moderna na Ciência da Informação, com o patrimônio, o desenvolvimento de coleções, a gestão informacional e do conhecimento, a organização e representação do conhecimento, os estudos métricos da informação e a web semântica, temáticas reportadas nesta edição.Nestas temáticas temos sete artigos científicos:- Biblioteca Rio-Grandense: um estudo de caso sob o viés da educação patrimonial (Marcia Carvalho Rodrigues e Pamela da Conceição Santos);- Desafios para a biblioteca pública no processo de planejamento da formação e desenvolvimento do acervo (Ana Cláudia Carvalho de Miranda, Mônica Marques Carvalho Gallotti e Adriano Cecatto);- Tipos e usos de ferramentas de apoio a gestão do conhecimento em empresa de tecnologia da informação (Fabio Correa, Fabricio Ziviani e Flávia Braga Chinelato);- Protocolo verbal em grupo na pesquisa brasileira em organização e representação do conhecimento (Roberta Cristina Dal'Evedove Tartarotti, Paula Regina Dal'Evedove e Mariângela Spotti Lopes Fujita);- Um processo para caracterização e análise de redes de colaboração científica institucional (Thiago Magela Rodrigues Dias, Roberth Santos Gomes, Jhonatan Fernando Oliveira e Gray Farias Moita);- Expressão científica de Mato Grosso na pesquisa brasileira sobre indicadores socioambientais no agronegócio na base de dados Cab Abstracts (Maykon Jesse Barbieri de Camargo);- Europeana no Linked Open Data: conceitos de web semântica na dimensão aplicada das humanidades digitais (Caio Saraiva Coneglian e José Eduardo Santarem Segundo). Também contamos com a presença de uma resenha, A Biblioteconomia de David Lankes (Jorge Moisés Kroll do Prado) referente a obra The New Librarianship field guide, publicado pela MIT Press em 2016. Boa leitura.
Urbanization effect on trends in sunshine duration in China
Authors: Wang Yawen , Wild Martin , Sanchez-Lorenzo Arturo , Manara Veronica 
Published: July 2017

Abstract. There is an ongoing debate on whether the observed decadal variations in surface solar radiation, known as dimming and brightening periods, are a large-scale or solely local phenomenon. We investigated this issue using long-term sunshine duration records from China, which experienced a rapid increase in urbanization during the past decades. Over the period 1960–2013, 172 pairs of urban and nearby rural stations were analyzed. Urban and rural sunshine duration trends show similar spatial patterns during a dimming phase (1960–1989) and a subsequent period during which trends were leveling off (1990–2013). This indicates that rather than local effects, the trends in sunshine duration are on more of a national or regional scale in China. Nevertheless, in the dimming phase, the declining rate of sunshine duration in rural areas is around two-thirds of that in urban areas. The ratio of rural to urban dimming generally increases from a minimum of 0.39 to a maximum of 0.87 with increasing indices of urbanization calculated based on the year 2013. It reaches a maximum when the urbanization level exceeds 50 %, the urban population exceeds 20 million, or the population density becomes higher than 250 person km−2. After the transition into the leveling-off period, sunshine duration trends are no longer significantly affected by urbanization. Meanwhile, the number of laws and regulations related to air pollution and investment in pollution treatment have been increasing in China.
O papel do município na conservação da biodiversidade / The role of the municipality in biodiversity conservation
Authors: Senteio Smith Welber , Dias da Mota Junior Vidal , Ramos Castellari Rafael 
Published: July 2017

O Brasil é um dos países com a maior diversidade biológica do planeta, abrigando entre 15 e 20% do número total de espécies. Parte dessa riqueza tem sido perdida de forma inexorável, portanto, é necessário conhecer com mais profundidade o patrimônio natural do país, identificar os principais fatores que os ameaçam e estabelecer prioridades de ação. O conhecimento, respaldado no rigor científico, constitui instrumento poderoso para envolver de forma definitiva a ação do poder público no processo de planejamento e conservação que, assim, podem instituir instrumentos de controle, fiscalização e proteção mais eficazes. Como um país federado, ou seja, com diferentes níveis de governo que compõe o Estado Brasileiro: União, Estados e Municípios, faz-se cada vez mais necessária a ação municipal na conservação da biodiversidade. Neste sentido, o município de Sorocaba, por meio da Secretaria Municipal do Meio Ambiente, desenvolveu uma série de mecanismos pautados em politicas públicas (planos, criação de parques e o jardim botânico, unidades de conservação, ações de educação ambiental e o programa Sorocaba a cidade da biodiversidade) que constituem casos de sucesso para a agenda biodiversidade local e que pode ser replicados para outros municípios.
INICIATIVAS DE USO POPULAR E REGULAÇÃO DEMOCRÁTICA DA BIODIVERSIDADE EM MEIO À CRISE AMBIENTAL PARA REDUÇÃO DA POBREZA E PROMOÇÃO DA QUALIDADE DE VIDA
Authors: Vidotte Blanco Tárrega Maria Cristina , Teles Jr Adenevaldo 
Published: July 2017

A biodiversidade tem valor econômico no mundo dominado pelo mercado. Hoje há a mercantilização da natureza e a privatização dos bens de uso comum, como a água, além de extratos vegetais. O uso da biodiversidade é do domínio das comunidades tradicionais. A proteção da biodiversidade por meio da garantia de direito às comunidades tradicionais e aos seus territórios e é uma forma de mitigar a pobreza e promover a justa distribuição de riquezas. O acesso popular à biodiversidade, apesar de aparentemente modesto, sugere uma nova relação com a economia e os recursos e patrimônios da Terra. É preciso cada vez mais exercer a governança ambiental na perspectiva de regular e promover uma gestão participativa da biodiversidade pelo reconhecimento dos sujeitos coletivos e das suas territorialidades.
FUNÇÃO SOCIAL DA PROPRIEDADE: A CONSTITUIÇÃO ECONÔMICA O DESENVOLVIMENTO SUSTENTÁVEL
Authors: Possas Thiago Lemos , Maniglia Elisabete 
Published: July 2017

O presente trabalho versa sobre a função social da propriedade, sua localização na Constituição Econômica presente na Constituição da República de 1988, bem como sua relação com o conceito de sustentabilidade, muito em voga hodiernamente. Busca-se, ainda, tratar a função social de forma crítica, através da abordagem de suas limitações intrínsecas, bem como da falta de compreensão e recepção por parte do mundo jurídico-institucional. E o enfoque a ser dado, cabe enfatizar, é eminentemente o da função social da propriedade agrária. Almeja-se ressaltar, por fim, que a correta consideração da função social da propriedade poderá converter-se em um primeiro passo para a configuração de uma sociedade mais harmônica, solidária e includente.
When Field Recordings Meet Field Research: Examining Change in the Shango Drumming of Postwar Trinidad
Authors: Bazinet Ryan J. 
Published: July 2017

Abstract
This article explores the historical changes in Trinidadian Shango drumming between 1939 and 1960. Building on dissertation field research conducted from 2008 to 2013, the study is focused on archived field recordings from Trinidad. The recordings reveal two styles of Shango drumming: one that by 1960 had coalesced into the modern style still performed today, and another that in 1939 revealed an older, more polyrhythmic style perhaps representative of nineteenth-century Yoruba drumming in Trinidad. The findings show that the study of field recordings can lead to a reconsideration of academic and popular discourses.
Este trabajo explora los cambios de estilo en la música de tambores del Shangó de Trinidad entre 1939 y 1960. El ensayo se basa en la investigación de campo de la tesis doctoral del autor realizada desde 2008 hasta 2013. Este estudio se centra en las grabaciones de campo de esta música en Trinidad, y las grabaciones revelan dos estilos de percusión en Shangó: uno que para el 1960 se había convertido en el estilo moderno que se sigue realizando hoy día, y otro que, en 1939, revela un estilo más antiguo, más polirrítmico, y tal vez más representativo del estilo yoruba del siglo diecinueve en Trinidad. Los resultados muestran que el estudio de grabaciones de campo puede conducir a una reconsideración de los discursos académicos y populares.
Polish Paremic Demotivators: Tradition in an Internet Genre
Authors: Szpila Grzegorz 
Published: July 2017

Abstract
The author examines the use of proverbs in Polish demotivators, an Internet memetic genre. The article discusses the place of proverbs in Internet folklore and places the concepts of demotivator and proverb amongst memetic phenomena. The study focuses on paremic demotivators (satires of motivational posters that contain a proverb) extracted from Polish websites devoted to demotivational creativity and examines the structure of paremic demotivators with an eye to describing the role of paremias in the structure of demotivators. The author classifies paremic demotivators on the basis of the proverbs’ form, meaning, and function.
Music Editing: Process to Practice—Bridging the Varied Perspectives in Filmmaking and Storytelling: 2016 Music and the Moving Image Conference Keynote Address
Authors: Allen Nancy 
Published: July 2017

Abstract
While the technical aspects of music editing and filmmaking continue to evolve, the fundamental nature of storytelling remains the same. Ideally, the role of the music editor exists at an intersection between the composer, director, and picture editor, where important creative decisions are made. The music editor initiates the first foray into a film’s musical aesthetics—creating a temp score that breathes new life into the film and serves as a guide track for the composer. When the composer arrives, the music editor facilitates smooth communication and translation between composer and director and ensures the realization of the score. Lastly, the music editor serves as the composer’s advocate in all stages of production and chaperones the music from cradle to grave. This privileged position allows the music editor to better explore how to tell the story through music and bring the evolving vision of the film into tighter focus.
Hearing and Seeing with Sergio Leone’s Once Upon a Time in the West (1968): Toward Dispelling Audio-Visual Hierarchy
Authors: Durrand Mark 
Published: July 2017

Abstract
The conventional cohabitation of cinematic sounds and their implied sources engenders a close and cooperative partnership between the senses of hearing and sight in the process of experiencing film. In this article, I explore the effects of film sounds that become separated from their sources. Specifically, I will argue that audio-visual dislocations create a rift within the intersensory relationship and invoke an anxiety-driven process aimed at mending the partnership by visually locating the source of the sound.
Zaufanie w zespołach pracowniczych – czy polskie zespoły są gotowe na empowerment?
Authors: Krawczyk-Bryłka Beata 
Published: July 2017

Zaufanie jest istotnym elementem klimatu pracy zespołowej i warunkiem budowania efektywnych zespołów, korzystających z potencjału zaangażowanych w realizację celu pracowników. Zaufanie jest też podstawą wdrażania w zespołach zasad empowermentu, rozumianego nie tylko jako przekazanie władzy członkom zespołu, lecz również jako zdolność zespołu do przejmowania odpowiedzialności za realizację wybranego celu. W artykule przedstawiono przegląd literatury podkreślającej związki między poziomem zaufania a empowermentem w zespołach. W badaniach skoncentrowano się na ocenie poziomu zaufania horyzontalnego (pomiędzy członkami zespołu) i poziomu zaufania wertykalnego (pracowników wobec lidera) w zespołach pracowniczych. Dokonano też oceny oczekiwań pracowników dotyczących tych dwóch wymiarów zaufania, co pozwoliło zidentyfikować luki zaufania. Wskazują one obszary do wdrażania rozwiązań wspiera‑ jących kształtowanie klimatu zaufania i empowermentu w zespołach i w organizacjach.
Certified Reference Material for Use in 1H, 31P, and 19F Quantitative NMR, Ensuring Traceability to the International System of Units
Authors: Rigger Romana , Rück Alexander , Hellriegel Christine , Sauermoser Robert , Morf Fabienne , Breitruck Kathrin , Obkircher Markus 
Published: July 2017

Abstract
In recent years, quantitative NMR (qNMR) spectroscopy has become one of the most important tools for content determination of organic substances and quantitative evaluation of impurities. Using Certified Reference Materials (CRMs) as internal or external standards, the extensively used qNMR method can be applied for purity determination, including unbroken traceability to the International System of Units (SI). The implementation of qNMR toward new application fields, e.g., metabolomics, environmental analysis, and physiological pathway studies, brings along morecomplex molecules and systems, thus making use of 1H qNMR challenging. A smart workaround is possible by the use of other NMR active nuclei, namely 31P and 19F. This article presents the development of three classes of qNMR CRMs based on different NMR active nuclei (1H, 31P, and 19F), and the corresponding approaches to establish traceability to the SI through primary CRMs from the National Institute of Standards and Technology and the National Metrology Institute of Japan. These TraceCERT® qNMR CRMs are produced under ISO/IEC 17025 and ISO Guide 34 using high-performance qNMR.
[Acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD)]
Authors: Urso Domenico Lorenzo 
Published: July 2017

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Acute exacerbations of COPD (AECOPD) are important events in the natural history of this condition because they negatively impact health status, rate of hospitalization, disease progression, and mortality.Viral and/or bacterial infections are the main cause of exacerbations. The treatments include systemic corticosteroids, bronchodilators, anticholinergics and/or short- or long-acting β2-agonists, and antibiotics in case of bacterial infections. In some cases, oxygen-therapy is indicated.This article focuses on several aspects of AECOPD, including epidemiology, diagnostic approach, i.e. investigations and management of AECOPD.
Nano-sized zeolites as modulators of thiacloprid toxicity onChironomus riparius
Authors: Lorenz Carla S. , Wicht Anna-Jorina , Guluzada Leyla , Crone Barbara , Karst Uwe , Lee Hwa Jun , Triebskorn Rita , Haderlein Stefan B. , Huhn Carolin , Köhler Heinz-R. 
Published: July 2017

This study investigated whether zeolites of different size (Y30 (nano-sized) and H-Beta(OH)-III (forming large aggregates/agglomerates composed of 50 nm small primary particles)) exerted acute toxicity on larvae of the non-biting midge,Chironomus riparius, and whether such zeolites are able to modulate the toxicity of a common insecticide, thiacloprid, by means of adsorption of a dissolved toxicant. We conducted acute toxicity tests with fourth instar larvae ofC. riparius. In these tests, larvae were exposed to zeolites or thiacloprid solely, or to mixtures of both compounds. The mixtures comprised 1.0 µg/L thiacloprid in addition to low (5.2 mg/L), medium (18.2 mg/L), and high (391.7 mg/L) zeolite concentrations, resulting in different adsorption rates of thiacloprid. As biological endpoints, changes in mortality rates and in behavior were monitored every 24 h over a total investigation period of 96 h. Furthermore, we conducted chemical analyses of thiacloprid in the medium and the larvae and located the zeolite particles within the larvae by LA-ICP-MS imaging techniques. Our results demonstrate that both types of zeolites did not exert acute toxicity when applied as single-substances, but led to reduced acute toxicity of thiacloprid when applied together with thiacloprid. These results are in line with the sorption properties of zeolites indicating reduced bioavailability of thiacloprid, although our data indicate that thiacloprid can desorb from zeolites to some extent. While freely dissolved (i.e., non-sorbed) fraction of thiacloprid was a good parameter to roughly estimate toxic effects, it did not correlate with measured internal thiacloprid concentrations. Moreover, it was shown that both zeolite types were ingested by the larvae, but no indication for cellular uptake of them was found.
Identifying the 630 nm auroral arc emission height: A comparison of the triangulation, FAC profile, and electron density methods
Authors: Megan Gillies D. , Knudsen D. , Donovan E. , Jackel B. , Gillies R. , Spanswick E. 
Published: July 2017

AbstractWe present a comprehensive survey of 630 nm (red‐line) emission discrete auroral arcs using the newly deployed Redline Emission Geospace Observatory. In this study we discuss the need for observations of 630 nm aurora and issues with the large‐altitude range of the red‐line aurora. We compare field‐aligned currents (FACs) measured by the Swarm constellation of satellites with the location of 10 red‐line (630 nm) auroral arcs observed by all‐sky imagers (ASIs) and find that a characteristic emission height of 200 km applied to the ASI maps gives optimal agreement between the two observations. We also compare the new FAC method against the traditional triangulation method using pairs of all‐sky imagers (ASIs), and against electron density profiles obtained from the Resolute Bay Incoherent Scatter Radar‐Canadian radar, both of which are consistent with a characteristic emission height of 200 km.
Statistical study of polar negative magnetic bays driven by interplanetary fast‐mode shocks
Authors: Liou Kan , Sotirelis Thomas , Gjerloev Jesper 
Published: July 2017

AbstractThe question of whether an interplanetary (IP) fast‐mode shock can trigger the substorm expansion is still not resolved. Some scientists believe that the substorm expansion can be triggered by a sudden compression of the magnetosphere if a substorm growth phase is in progress (e.g., the magnetosphere precondition hypothesis). Such a hypothesis has not been rigorously tested. Here we study 258 positive sudden impulse (SI+) events associated with interplanetary fast‐mode shocks observed by the ACE spacecraft from 1998 to 2009. The westward auroral electrojet SML index, derived from the SuperMAG network geomagnetic field data, is used to check for negative magnetic bays. It is found that the probability of having a magnetic bay onset that follows a shock impact peaks (~27%) sharply and immediately (within 3 min) after the shock‐induced SI+. This indicates that the majority of the shock events do not lead to magnetic bays. A superposed epoch analysis of the shock events associated with (Type‐Y) and without (Type‐N) negative bays indicates that the Type‐Y events had stronger (~40%) solar wind driving than the Type‐N ones. This result generally supports the magnetosphere precondition hypothesis. We also found that (1) Type‐Y events are associated with even stronger (~56%) solar wind driving downstream of the shock than Type‐N events and (2) there is a good correlation between the SML and the polar cap magnetic PC indices both upstream and downstream of the shock. It is suggested that sharp decreases in SML immediately after a shock impact are not associated with the substorm‐driven DP‐1 current system but with the convection‐driven DP‐2 current system.