bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hygroscopic Coating of Sulfuric Acid Shields Oxidant Attack on the Atmospheric Pollutant Benzo(a)pyrene Bound to Model Soot Particles
Authors: Ray Debajyoti , Bhattacharya Tara Shankar , Chatterjee Abhijit , Singha Achintya , Ghosh Sanjay K. , Raha Sibaji 
Published: January 2018

AbstractSubstantial impacts on climate have been documented for soot‒sulfuric acid (H2SO4) interactions in terms of optical and hygroscopic properties of soot aerosols. However, the influence of H2SO4 on heterogeneous chemistry on soot remains unexplored. Additionally, oxidation rate coefficients for polycyclic aromatic hydrocarbons intrinsic to the atmospheric particles evaluated in laboratory experiments seem to overestimate their degradation in ambient atmosphere, possibly due to matrix effects which are hitherto not mimicked in laboratory experiments. For the first time, our kinetics study reports significant influence of H2SO4 coating on heterogeneous ozonation of benzo(a)pyrene (BaP) deposited on model soot, representative to atmospheric particles. The approximate specific surface area of model soot (5 m2g−1) was estimated as a measure of the availability of surface molecules to a typical gaseous atmospheric oxidant. Heterogeneous bimolecular reaction kinetics and Raman spectroscopy studies suggested plausible reasons for decreased BaP ozonation rate in presence of H2SO4: 1. decreased partitioning of O3 on soot surface and 2. shielding of BaP molecules to gaseous O3 by acid-BaP reaction or O3 oxidation products.
Primed primary metabolism in systemic leaves: a functional systems analysis
Authors: Schwachtje Jens , Fischer Axel , Erban Alexander , Kopka Joachim 
Published: January 2018

AbstractPlants evolved mechanisms to counteract bacterial infection by preparing yet uninfected systemic tissues for an enhanced defense response, so-called systemic acquired resistance or priming responses. Primed leaves express a wide range of genes that enhance the defense response once an infection takes place. While hormone-driven defense signalling and defensive metabolites have been well studied, less focus has been set on the reorganization of primary metabolism in systemic leaves. Since primary metabolism plays an essential role during defense to provide energy and chemical building blocks, we investigated changes in primary metabolism at RNA and metabolite levels in systemic leaves of Arabidopsis thaliana plants that were locally infected with Pseudomonas syringae. Known defense genes were still activated 3–4 days after infection. Also primary metabolism was significantly altered. Nitrogen (N)-metabolism and content of amino acids and other N-containing metabolites were significantly reduced, whereas the organic acids fumarate and malate were strongly increased. We suggest that reduction of N-metabolites in systemic leaves primes defense against bacterial infection by reducing the nutritional value of systemic tissue. Increased organic acids serve as quickly available metabolic resources of energy and carbon-building blocks for the production of defense metabolites during subsequent secondary infections.
The Effect of Gravity on Flame Spread over PMMA Cylinders
Authors: Link Shmuel , Huang Xinyan , Fernandez-Pello Carlos , Olson Sandra , Ferkul Paul 
Published: January 2018

AbstractFire safety is a concern in space travel, particularly with the current plans of increasing the length of the manned space missions, and of using spacecraft atmospheres different than in Earth, such as microgravity, low-velocity gas flow, low pressure and elevated oxygen concentration. In this work, the spread of flame over a thermoplastic polymer, polymethyl methacrylate (PMMA), was conducted in the International Space Station and on Earth. The tests consisted of determining the opposed flame spread rate over PMMA cylinders under low-flow velocities ranging from 0.4 to 8 cm/s and oxygen concentrations from 15% to 21%. The data show that as the opposed flow velocity is increased, the flame spread rate first increases, and then decreases, different from that on Earth. The unique data are significant because they have only been predicted theoretically but not been observed experimentally before. Results also show that flame spread in microgravity could be faster and sustained at lower oxygen concentration (17%) than in normal gravity (18%). These findings suggest that under certain environmental conditions there could be a higher fire risk and a more difficult fire suppression in microgravity than on Earth, which would have significant implications for spacecraft fire safety.
High-Energy, Short-Duration Bursts of Coherent Terahertz Radiation from an Embedded Plasma Dipole
Authors: Kwon Kyu Been , Kang Teyoun , Song Hyung Seon , Kim Young-Kuk , Ersfeld Bernhard , Jaroszynski Dino A. , Hur Min Sup 
Published: January 2018

AbstractEmission of radiation from electrons undergoing plasma oscillations (POs) at the plasma frequency has attracted interest because of the existence of intriguing and non-trivial coupling mechanism between the electrostatic PO and the emitted electromagnetic wave. While broadband emission from plasma waves in inhomogeneous plasma is well known, the underlying physics of narrowband emission at the plasma frequency observed in experiments and in solar radio-bursts is obscure. Here we show that a spatially-localized plasma dipole oscillation (PDO) can be generated when electrons are trapped in a moving train of potential wells produced by the ponderomotive force of two slightly detuned laser pulses that collide in plasma and give rise to a burst of quasi-monochromatic radiation. The energy radiated in the terahertz spectral region can reach an unprecedented several millijoules, which makes it suitable for applications requiring short pulses of high-intensity, narrowband terahertz radiation.
Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours
Authors: Martinez Victor D. , Firmino Natalie S. , Marshall Erin A. , Ng Kevin W. , Wadsworth Brennan J. , Anderson Christine , Lam Wan L. , Bennewith Kevin L. 
Published: January 2018

AbstractHypoxia promotes tumour aggressiveness and reduces patient survival. A spectrum of poor outcome among patients with hypoxic tumours suggests that additional factors modulate how tumours respond to hypoxia. PIWI-interacting RNAs (piRNAs) are small non-coding RNAs with a pivotal role in genomic stability and epigenetic regulation of gene expression. We reported that cancer type-specific piRNA signatures vary among patients. However, remarkably homogenous piRNA profiles are detected across patients with renal cell carcinoma, a cancer characterized by constitutive upregulation of hypoxia-related signaling induced by common mutation or loss of von Hippel-Lindau factor (VHL). By investigating >3000 piRNA transcriptomes in hypoxic and non-hypoxic tumors from seven organs, we discovered 40 hypoxia-regulated piRNAs and validated this in cells cultured under hypoxia. Moreover, a subset of these hypoxia-regulated piRNAs are regulated by VHL/HIF signaling in vitro. A hypoxia-regulated piRNA-based score (PiSco) was associated with poor RFS for hypoxic tumours, particularly Stage I lung adenocarcinomas, suggesting that hypoxia-regulated piRNA expression can predict tumour recurrence even in early-stage tumours and thus may be of clinical utility.
Ferroelectric Domain Studies of Patterned (001) BiFeO3 by Angle-Resolved Piezoresponse Force Microscopy
Authors: Kim Bumsoo , Barrows Frank P. , Sharma Yogesh , Katiyar Ram S. , Phatak Charudatta , Petford-Long Amanda K. , Jeon Seokwoo , Hong Seungbum 
Published: January 2018

AbstractWe have studied the ferroelectric domains in (001) BiFeO3 (BFO) films patterned into mesas with various aspect ratios, using angle-resolved piezoresponse force microscope (AR-PFM), which can image the in-plane polarization component with an angular resolution of 30°. We observed not only stable polarization variants, but also meta-stable polarization variants, which can reduce the charge accumulated at domain boundaries. We considered the number of neighboring domains that are in contact, in order to analyze the complexity of the ferroelectric domain structure. Comparison of the ferroelectric domains from the patterned and unpatterned regions showed that the elastic relaxation induced by removal of the film surrounding the mesas led to a reduction of the average number of neighboring domains, indicative of a decrease in domain complexity. We also found that the rectangular BFO patterns with high aspect ratio had a simpler domain configuration and enhanced piezoelectric characteristics than square-shaped mesas. Manipulation of the ferroelectric domains by controlling the aspect ratio of the patterned BFO thin film mesas can be useful for nanoelectronic applications.
Preventive and promotive effects of habitual hot spa-bathing on the elderly in Japan
Authors: Maeda Toyoki , Mimori Koshi , Suzuki Sadao , Horiuchi Takahiko , Makino Naoki 
Published: January 2018

AbstractAlthough body-warming with hot spa-bathing has been proposed to exert medical therapeutic effects on certain diseases, whether body-warming has preventive and promotive effects remains unknown. To clarify this issue, an epidemiological questionnaire study regarding personal hot spa-bathing habits and disease history was carried out in Japan, where individuals engage in daily warm water bathing. Questionnaires regarding hot spa-bathing habits and disease history were randomly sent to 20,000 residents aged ≥65 years living in Beppu, a city in Japan that has the highest concentration of hot spa sources in the world. The results showed that habitual hot spa-bathing exerts preventive or promotive effects on the occurrence of certain diseases, such as hypertension (preventive) and collagen disease (promotive) in women, and cardiovascular diseases (preventive) and colon cancer survival (promotive) in men. These findings suggest that habitual body warming is an effective and economical method with beneficial preventive and promotive effects on various diseases.
The synergistic bactericidal effect of vancomycin on UTMD treated biofilm involves damage to bacterial cells and enhancement of metabolic activities
Authors: Hu Jian , Zhang Ning , Li Lifang , Zhang Ning , Ma Yanfen , Zhao Chedong , Wu Qian , Li Ying , He Nianan , Wang Xiaoqin 
Published: January 2018

AbstractIn this study, the synergistic effect of vancomycin, a cell wall synthesis inhibitor, and ultrasound-targeted microbubble destruction (UTMD), on cell viability of Staphylococcus epidermidis, embedded in biofilm, was investigated. Biofilms are the leading causes of antibiotic-resistant bacterial infections of medical implants and prosthetics worldwide. The antibiotic-resistant nature of biofilm-embedded pathogens poses a critical challenge to the medical community. Previously, studies have demonstrated the efficacy of using ultrasound waves and UTMD in circumventing this problem. However, the mechanism(s) underlying this phenomenon was not clear. Here, the present study showed that both ultrasound and UTMD damaged the cell wall structure of S. epidermidis, and floccules and fragments from damaged cells were observed on transmission electron microscope micrograph. However, the cell membrane integrity was not seriously affected by treatments, and the treatment increased the metabolic activity levels of the dormant biofilm-embedded bacteria, detected by confocal laser scanning microscope and flow cytometry, which could make them susceptible to the effect of the antibiotic. Thus, the biological mechanism underlying the efficacy of the combined treatment involving UTMD and vancomycin in the case of S. epidermidis biofilm was dissected, which may be utilized for further investigations on other biofilm pathogens before clinical use.
Biofilm Formation Protects Salmonella from the Antibiotic Ciprofloxacin In Vitro and In Vivo in the Mouse Model of chronic Carriage
Authors: González Juan F. , Alberts Halley , Lee Joel , Doolittle Lauren , Gunn John S. 
Published: January 2018

AbstractTyphoid fever is caused by the human-restricted pathogen Salmonella enterica sv. Typhi. Approximately 5% of people that resolve the disease become chronic carriers, with the gallbladder as the main reservoir of the bacteria. Of these, about 90% present with gallstones, on which Salmonella form biofilms. Because S. Typhi is a human-restricted pathogen, these carriers are the main source of dissemination of the disease; unfortunately, antibiotic treatment has shown to be an ineffective therapy. This is believed to be caused by the inherent antibiotic resistance conferred by Salmonella biofilms growing on gallstones. The gallstone mouse model with S. Typhimurium has proven to be an excellent surrogate for S. Typhi chronic infection. In this study, we test the hypothesis that the biofilm state confers Salmonella with the increased resistance to antibiotics observed in cases of chronic carriage. We found that, in the biofilm state, Salmonella is significantly more resistant to ciprofloxacin, a common antibiotic used for the treatment of Salmonella, both in vitro (p < 0.001 for both S. Typhi and S. Typhimurium with respect to planktonic cells) and in vivo (p = 0.0035 with respect to control mice).
Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China
Authors: Yang Fang , Zheng Yanmin , Jiang Xihui , Su Zhengyan , Wang Ya , Lin Lin , Lv Houning , Zhang Jie , Zhao Jingwen , Wang Bangmao , Jiang Kui , Sun Chao 
Published: January 2018

AbstractAs the world’s most populated and rapidly aging country, there is limited information on sex-related differences in factors regarding uncomplicated colonic diverticulosis in China. We aimed to investigate sex differences in individual risk factor in a northern metropolis. Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features. Demographic information, life style factors and co-morbidities were retrieved from a prospective dataset. Multiple regression analyses were performed to determine precipitating factors of diverticula. Of 4,386 enrolled patients, colonic diverticulosis were detected in 218 cases (4.97%). Multiple logistic regression analysis implicated increasing age (OR = 1.05, 95%CI 1.03–1.06, P < 0.001), red meat ≥100 g/d (OR = 2.53, 95%CI 1.72–3.70, P < 0.001), smoking (OR = 2.14, 95%CI 1.05–4.33, P = 0.035), rheumatologic diseases (OR = 3.38, 95%CI 1.09–10.5, P = 0.035) and NSAIDs (OR = 2.11, 95%CI 1.12–3.97, P = 0.020) were significantly associated with diverticulosis in men, whilst advancing age (OR = 1.03, 95%CI 1.01–1.05, P = 0.013), BMI (OR = 1.12, 95%CI 1.04–1.19, P = 0.001), smoking (OR = 10.2, 95%CI 2.81–37.4, P < 0.001), rheumatologic diseases (OR = 8.04, 95%CI 3.05–21.2, P < 0.001), hypertension (OR = 1.76, 95%CI 1.01–3.06, P = 0.047), colonic polyps (OR = 3.12, 95%CI 1.82–5.36, P < 0.001) and antihypertensive medications (OR = 2.99, 95%CI 1.66–5.39, P < 0.001) in women. In conclusion, it is pivotal to take account of differentially sex-related factors in regard to the development of uncomplicated colonic diverticulosis.
MUC4 immunohistochemistry is useful in distinguishing epithelioid mesothelioma from adenocarcinoma and squamous cell carcinoma of the lung
Authors: Mawas Amany Sayed , Amatya Vishwa Jeet , Kushitani Kei , Kai Yuichiro , Miyata Yoshihiro , Okada Morihito , Takeshima Yukio 
Published: January 2018

AbstractThe differential diagnosis of epithelioid mesothelioma from lung adenocarcinoma and squamous cell carcinoma requires the positive and negative immunohistochemical markers of mesothelioma. The IMIG guideline has suggested the use of Calretinin, D2–40, WT1, and CK5/6 as mesothelial markers, TTF-1, Napsin-A, Claudin 4, CEA as lung adenocarcinoma markers p40, p63, CK5/6, MOC-31 as squamous cell markers. However, use of other immunohistochemical markers is still necessary. We evaluated 65 epithelioid mesotheliomas, 60 adenocarcinomas, and 57 squamous cell carcinomas of the lung for MUC4 expression by immunohistochemistry and compared with the previously known immunohistochemical markers. MUC4 expression was not found in any of 65 cases of epithelioid mesothelioma. In contrast, MUC4 expression was observed in 50/60(83.3%) cases of lung adenocarcinoma and 50/56(89.3%) cases of lung squamous cell carcinoma. The negative MUC4 expression showed 100% sensitivity, 86.2% specificity and accuracy rate of 91.2% to differentiate epithelioid mesothelioma from lung carcinoma. The sensitivity, specificity, and accuracy of MUC4 are comparable to that of previously known markers of lung adenocarcinoma and squamous cell carcinoma, namely CEA, Claudin 4 and better than that of MOC-31. In conclusion, MUC4 immunohistochemistry is useful for differentiation of epithelioid mesothelioma from lung carcinoma, either adenocarcinoma or squamous cell carcinoma.
Enhanced nasal drug delivery efficiency by increasing mechanical loading using hypergravity
Authors: Kim Dongjoo , Kim Young Hyo , Kwon Soonjo 
Published: January 2018

AbstractNasal route drug administration for local and systemic delivery of many therapeutics has received attention because the nasal cavity is highly vascularized and provides a large surface area for drug absorption. However, nasal mucosa exhibits limited permeability to polar molecules. In this study, we developed a novel method for improving absorption efficiency of polar drugs by applying hypergravity. RPMI 2650 cells and primary human nasal epithelial cells were exposed three times to a 20 min hypergravitational condition (10 × g) with a 20 min rest period after each exposure. The applied hypergravity induced a decrease in transepithelial electrical resistance without significant loss of cellular metabolic activity, and cellular permeability of fluorescein sodium salt (MW 376 Da; NaFI) and FITC-labeled dextran (average MW 4,000 Da; FD-4) increased by 19% and 16%, respectively. Immunostaining and RT-qPCR results demonstrated that hypergravity conditions affected cytoskeletal structures and tight junctions, leading to weakening of the cell barrier function and increasing the cellular permeability of polar molecules. Our results indicate that hypergravity could be used as a new strategy for enhancing the efficiency of drug absorption via the nasal route.
Photochemistry and the role of light during the submerged photosynthesis of zinc oxide nanorods
Authors: Zhang Lihua , Jeem Melbert , Okamoto Kazumasa , Watanabe Seiichi 
Published: January 2018

AbstractRecently, metal oxide nanocrystallites have been synthesized through a new pathway, i.e., the submerged photosynthesis of crystallites (SPSC), and flower-like ZnO nanostructures have been successfully fabricated via this method. However, the photochemical reactions involved in the SPSC process and especially the role of light are still unclear. In the present work, we discuss the reaction mechanism for SPSC-fabricated ZnO nanostructures in detail and clarify the role of light in SPSC. The results show that both photoinduced reactions and hydrothermal reactions are involved in the SPSC process. The former produces OH radicals, which is the main source of OH
−
at the ZnO crystal tips, whereas the latter generates ZnO. Although ZnO nanocrystals can be obtained under both UV irradiation and dark conditions with the addition of thermal energy, light promotes ZnO growth and lowers the water pH to neutral, whereas thermal energy promotes ZnO corrosion and increases the water pH under dark conditions. The study concludes that the role of light in the submerged photosynthesis of crystallites process is to enhance ZnO apical growth at relatively lower temperature by preventing the pH of water from increasing, revealing the environmentally benign characteristics of the present process.
Radiation characteristics of natural gamma-ray from coal and gangue for recognition in top coal caving
Authors: Zhang Ningbo , Liu Changyou 
Published: January 2018

AbstractRecognition of coal and gangue (roof rock) is a key technology to realize fully mechanized top coal caving automated mining. This paper proposes to detect the instantaneous refuse content of drawn coal and gangue mixture during top coal caving by using natural gamma-ray technology. The generating environment of coal and rock seams, the distribution characteristics of natural gamma ray from coal and roof-rock and the principle of coal-gangue recognition using natural gamma-ray method were analyzed. The natural gamma ray radiation characteristics of coal and roof-rock seams from seven different typical coal mine areas who has thick coal seams in China have been researched, and a connection between radiation intensity and refuse content was set up. The experiments on the mixed condition of roof-rock drawn from caving opening in the caving process of fully-mechanized top coal caving working face was taken and the radiative signals was real-time detected by using the self-developed coal-gangue recognition experimental system. The experiments results demonstrate the feasibility of using natural gamma-ray technology to perform real-time detection of refuse content of drawn coal and gangue mixture and the availability of self-developed coal-gangue recognition detector.
Mobile and pervasive computing technologies and the future of Alzheimer’s clinical trials
Authors: Doraiswamy P. Murali , Narayan Vaibhav A. , Manji Husseini K. 
Published: January 2018

AbstractThe rapid growth of mobile phones, automated speech recognizing personal assistants, and internet access among the elderly provides new opportunities for incorporating such technologies into clinical research and personalized medical care. Alzheimer’s disease is a good test case given the need for early detection, the high rate of clinical trial failures, the need to more efficiently recruit patients for trials, and the need for sensitive and ecologically valid trial outcomes.