bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of fluid responsiveness using pulse pressure variation, stroke volume variation, plethysmographic variability index, central venous pressure, and inferior vena cava variation in patients undergoing mechanical ventilation: a systematic review and meta-analysis
Authors: Chaves Renato Carneiro de Freitas , Barbas Carmen Silvia Valente , Queiroz Veronica Neves Fialho , Serpa Neto Ary , Deliberato Rodrigo Octavio , Pereira Adriano José , Timenetsky Karina Tavares , Silva Júnior João Manoel , Takaoka Flávio , de Backer Daniel , Celi Leo Anthony , Corrêa Thiago Domingos 
Published: August 2024

Abstract
Importance
Maneuvers assessing fluid responsiveness before an intravascular volume expansion may limit useless fluid administration, which in turn may improve outcomes.

Objective
To describe maneuvers for assessing fluid responsiveness in mechanically ventilated patients.

Registration
The protocol was registered at PROSPERO: CRD42019146781.

Information sources and search
PubMed, EMBASE, CINAHL, SCOPUS, and Web of Science were search from inception to 08/08/2023.

Study selection and data collection
Prospective and intervention studies were selected.

Statistical analysis
Data for each maneuver were reported individually and data from the five most employed maneuvers were aggregated. A traditional and a Bayesian meta-analysis approach were performed.

Results
A total of 69 studies, encompassing 3185 fluid challenges and 2711 patients were analyzed. The prevalence of fluid responsiveness was 49.9%. Pulse pressure variation (PPV) was studied in 40 studies, mean threshold with 95% confidence intervals (95% CI) = 11.5 (10.5–12.4)%, and area under the receiver operating characteristics curve (AUC) with 95% CI was 0.87 (0.84–0.90). Stroke volume variation (SVV) was studied in 24 studies, mean threshold with 95% CI = 12.1 (10.9–13.3)%, and AUC with 95% CI was 0.87 (0.84–0.91). The plethysmographic variability index (PVI) was studied in 17 studies, mean threshold = 13.8 (12.3–15.3)%, and AUC was 0.88 (0.82–0.94). Central venous pressure (CVP) was studied in 12 studies, mean threshold with 95% CI = 9.0 (7.7–10.1) mmHg, and AUC with 95% CI was 0.77 (0.69–0.87). Inferior vena cava variation (∆IVC) was studied in 8 studies, mean threshold = 15.4 (13.3–17.6)%, and AUC with 95% CI was 0.83 (0.78–0.89).

Conclusions
Fluid responsiveness can be reliably assessed in adult patients under mechanical ventilation. Among the five maneuvers compared in predicting fluid responsiveness, PPV, SVV, and PVI were superior to CVP and ∆IVC. However, there is no data supporting any of the above mentioned as being the best maneuver. Additionally, other well-established tests, such as the passive leg raising test, end-expiratory occlusion test, and tidal volume challenge, are also reliable.
Comparative analysis of phosphorylated proteomes between plerocercoid and adult Spirometra mansoni reveals phosphoproteomic profiles of the medical tapeworm
Authors: Liu Yong Yan , Wang Rui Jie , Ru Si Si , Gao Fei , Liu Wei , Zhang Xi 
Published: August 2024

Abstract
Background
Plerocercoid larvae of the tapeworm Spirometra mansoni can infect both humans and animals, leading to severe parasitic zoonosis worldwide. Despite ongoing research efforts, our understanding of the developmental process of S. mansoni remains inadequate. To better characterize posttranslational regulation associated with parasite growth, development, and reproduction, a comparative phosphoproteomic study was conducted on the plerocercoid and adult stages of S. mansoni.

Methods
In this study, site-specific phosphoproteomic analysis was conducted via 4D label-free quantitative analysis technology to obtain primary information about the overall phosphorylation status of plerocercoids and adults.

Results
A total of 778 differentially abundant proteins (DAPs) were detected between adults and plerocercoids, of which 704 DAPs were upregulated and only 74 were downregulated. DAPs involved in metabolic activity were upregulated in plerocercoid larvae compared with adults, whereas DAPs associated with binding were upregulated in adults. Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analyses indicated that most DAPs involved in signal transduction and environmental information processing pathways were highly active in adults. DAPs upregulated in the plerocercoid group were enriched mainly in metabolic activities. The kinases PKACA, GSK3B, and smMLCK closely interact, suggesting potential active roles in the growth and development of S. mansoni.

Conclusions
The dataset presented in this study offers a valuable resource for forthcoming research on signaling pathways as well as new insights into functional studies on the molecular mechanisms of S. mansoni.

Graphical abstract
mRNA vaccines in tumor targeted therapy: mechanism, clinical application, and development trends
Authors: Gao Yu , Yang Liang , Li Zhenning , Peng Xueqiang , Li Hangyu 
Published: August 2024

AbstractMalignant tumors remain a primary cause of human mortality. Among the various treatment modalities for neoplasms, tumor vaccines have consistently shown efficacy and promising potential. These vaccines offer advantages such as specificity, safety, and tolerability, with mRNA vaccines representing promising platforms. By introducing exogenous mRNAs encoding antigens into somatic cells and subsequently synthesizing antigens through gene expression systems, mRNA vaccines can effectively induce immune responses. Katalin Karikó and Drew Weissman were awarded the 2023 Nobel Prize in Physiology or Medicine for their great contributions to mRNA vaccine research. Compared with traditional tumor vaccines, mRNA vaccines have several advantages, including rapid preparation, reduced contamination, nonintegrability, and high biodegradability. Tumor-targeted therapy is an innovative treatment modality that enables precise targeting of tumor cells, minimizes damage to normal tissues, is safe at high doses, and demonstrates great efficacy. Currently, targeted therapy has become an important treatment option for malignant tumors. The application of mRNA vaccines in tumor-targeted therapy is expanding, with numerous clinical trials underway. We systematically outline the targeted delivery mechanism of mRNA vaccines and the mechanism by which mRNA vaccines induce anti-tumor immune responses, describe the current research and clinical applications of mRNA vaccines in tumor-targeted therapy, and forecast the future development trends of mRNA vaccine application in tumor-targeted therapy.
Cardioembolic stroke in Chagas disease: unraveling the underexplored connection through a systematic review
Authors: Vásconez-González Jorge , Miño Camila , Izquierdo-Condoy Juan S. , Salazar-Santoliva Camila , López-Cortés Andrés , Ortiz-Prado Esteban 
Published: August 2024

Abstract
Background
Chagas disease (CD), triggered by the Trypanosoma cruzi parasite, is originally endemic across Latin America, affecting millions. While cardiac complications are widely recognized, the association between CD and stroke remains underexplored. This systematic review aims to elucidate the relationship between CD and stroke, highlighting the cardioembolic origins of stroke in CD patients and assessing the elevated stroke risk compared to non-infected individuals.

Methodology
Adhering to the PRISMA guidelines, we conducted a comprehensive search in PubMed and Scopus databases without date restrictions, including articles in both Spanish and English. This approach enabled the identification and analysis of relevant studies to understand the interplay between CD and stroke risk.

Results
Our analysis of 25 selected studies indicates that strokes in CD patients predominantly arise from cardioembolic sources. The data underscore a significant increase in stroke risk among individuals infected with T. cruzi compared to uninfected counterparts. Additionally, CD patients face a higher stroke and mortality risk than those with other heart failure etiologies, irrespective of disease severity.

Conclusion
The review establishes CD as a critical contributor to stroke incidence, emphasizing the need for heightened awareness and diagnosis of CD in stroke patients, particularly in regions with high CD prevalence. Recognizing the increased stroke risk associated with T. cruzi infection is crucial for developing targeted educational and preventive strategies in endemic areas.
Approach to the Paediatric Patient With Suspected Pheochromocytoma or Paraganglioma Versus Neuroblastoma
Authors: Hendriks A Emile J , Burns Charlotte , Fleming Ben , Harper Ines , Hook Elizabeth , Armstrong Ruth , Pamporaki Christina , Eisenhofer Graeme , Murray Matthew J , Casey Ruth T 
Published: August 2024

Abstract
Catecholamine-producing tumors of childhood include neuroblastic tumors, phaeochromocytoma, and paraganglioma (PPGL). PPGL and neuroblastic tumors can arise in similar anatomical locations and clinical presentations can overlap, resulting in diagnostic challenges. Distinguishing between these tumor types is critical as management and long-term surveillance strategies differ depending on the diagnosis. Herein we describe 2 clinical cases and illustrate key considerations in the diagnostic workup of a neuroblastoma vs PPGL for patients presenting with adrenal, pelvic, and retroperitoneal masses in childhood.
Impact of tango on Parkinson's disease - a narrative review
Authors: Muzyk Magdalena , Duda Weronika , Mrowczyk Patrycja , Nowoświat Patrycja , Bado Michał , Goncerz Michał , Bilecki Krzysztof , Bednarczyk Paulina , Pilawska Sandra Agnieszka , Maślankiewicz Maria , Malaka Ewa Katarzyna 
Published: August 2024

Introduction: Parkinson’s disease (PD) is a fast-growing neurodegenerative condition caused by the deficiency of dopamine (Bloem et al., 2021). Main symptoms include tremor, bradykinesia, muscular rigidity and postural instability (Ye et al., 2023). Although PD treatment primarily involves pharmacotherapy, physical activity-based treatments such as tango dance can improve the quality of life of patients.
Aim of the study: This narrative review aims to assess the impact of the therapeutic benefits of tango dance therapy for people with PD.
Materials and methods: A comprehensive literature search was conducted in the PubMed database up to 2024. The review included randomised controlled trials, case reports, and pilot studies focused on the impact of tango on PD.
Results: Several studies have evaluated the impact of tango on patients with PD. Some of them found that tango improves dynamic balance and walking, reduces the risk of falling, improves body awareness, stability, and emotional well-being among patients with PD.
Conclusions: The impact of tango on PD is not yet conclusively documented, and further research is needed.
The role of supplementation in traumatic brain injury among athletes and non-athletes population
Authors: Pilawska Sandra Agnieszka , Bado Michał , Goncerz Michał , Nowoświat Patrycja , Bilecki Krzysztof , Bednarczyk Paulina , Malaka Ewa Katarzyna , Duda Weronika , Muzyk Magdalena , Maślankiewicz Maria 
Published: August 2024

Introduction: Traumatic brain injury (TBI) is one of the most common causes of death and long-term disability. The consequences following TBI can be persistent and cause life-long implications for survivors. Treatment of TBI may be complex and involve large monetary costs. The frequent injury mechanisms are traffic-related, falls, violence or sport-related accidents. Higher risk of brain injury and its complications indicate that people affected by brain trauma may benefit from the prophylactic and post-traumatic use of certain supplements both in the context of physical performance and in the event of potential injury.
Aim of the Study: This narrative review examines the current literature of the role of supplementation before and after TBI and its effects on the patient's outcome.
Materials and Methods: A comprehensive search was performed using PubMed and Google Scholar focusing on the literature published up to April 2024. The review included randomized controlled trials, meta-analyses, systematic reviews that focused on the use of creatine monohydrate, omega-3 fatty acids, magnesium and zinc in TBI and among the general population. Data of pathophysiology and epidemiology of TBI and safety profile of supplements were involved.
Results: The evidence indicates that the role of supplementation with creatine, omega-3 PUFAs and zinc is important in mitigating secondary damage after TBI, as well as in protecting against damage if administered before injury.
Conclusion: Because of the complex and multifactorial nature of the TBI more studies are required to constitute an effective nutrition-based strategy for reducing the cognitive and behavioral deficits associated with this injury. The evidence supporting multiple dietary components to improve a patient's outcome seems strong and the cost of its implementation is low. A group of particular interest that may benefit additionally are athletes who use dietary supplementation in their daily routine.
Neurological complications of infective endocarditis - a review
Authors: Stanicki Paweł , Szarpak Julita , Pażyra Aldona , Kusak Natalia , Żak Natalia , Jaworska Barbara 
Published: August 2024

Introduction and purpose
Infective endocarditis (IE) is a disease resulting from infection of the endocardium. In addition to cardiac symptoms, frequent complications of IE include various damage to the nervous system.
The aim of this study is to describe the current state of knowledge about the neurological complications of infective endocarditis.

Methods
Medical publications were reviewed using the "PubMed" and "Google Scholar" databases. The obtained results were verified in terms of the following criteria: publication in 2016, retrospective analysis, obtaining 44 papaers covering a total of 8067 patients. The information was supplemented with case reports and meta-analyses.

Description of the state of knowledge
Neurologic complications occur in 20 to 60% of patients with IE. The most common is ischemic stroke, the symptoms of which may precede the diagnosis of IE. Less common complications that often remain asymptomatic include mycotic aneurysms and intracranial hemorrhages. Infectious material entering the brain may also cause meningitis and brain abscess. However, these complications do not occur often. Magnetic resonance imaging of the head is an effective test for detecting neurological damage in the course of IE. The recommendation for routine use of this test is debatable. In addition to antibiotic therapy, cardiac surgery is used to treat IE to remove bacterial vegetation. Research indicates the high effectiveness of this type of surgery in the prevention and treatment of neurological complications of infective endocarditis.
CONSELHOS MUNICIPAIS DE EDUCAÇÃO DA REGIÃO METROPOLITANA DE SOROCABA/SP: INÍCIO DE CONVERSA (PRIMEIRA PARTE)
Authors: Lima Paulo Gomes 
Published: August 2024

A presente pesquisa por meio da equipe selecionada, se debruçará sobre a recorrência das maneiras em que os Conselhos Municipais de Educação e Municípios dialogam sobre as categorias de “participação”, “cidadania” e “educação socialmente referenciada”, conforme trabalho de Silva (2010) e que se utilizará como referência, para a compreensão de tal contextualização é necessário explicitar: a) O contexto histórico e a importância do município na região (no caso a região metropolitana de Sorocaba); b) Os marcos legais e estrutura educacional de cada um dos municípios estudados; c) Uma breve pontuação sobre o funcionamento dos Conselhos Municipais de Educação. A equipe mencionada é composta de pesquisadores, mestrandos e doutorandos vinculados ao Grupo de Estudos e Pesquisas Estado, Política, Planejamento, Avaliação e Gestão da Educação (GEPLAGE) da Universidade Federal de São Carlos - Campus Sorocaba.
Dakwah Lintas Iman Perspektif Said An-Nursi dalam Risala-i Nur dan Relevansinya dengan Gerakan Dakwah Lintas Iman di Indonesia
Authors: Hadi al-Asy’ari M Khoirul 
Published: August 2024

Penelitian ini - berbasis library reseach, dengan tema “Dakwah lintas Iman perpektif Said an-Nursi dalam Risala-i Nur dan relevansinya dengan gerakan Dakwah lintas iman di Indonesia. Dalam artikel ini ada beberapa pertanyaan penelitian yang menjadi fokus masalah, pertama bagaimana pandangan Said An-Nursi berkaitan dengan pola Dakwah keberagamaan (lintas Iman) dan keberimanan antar Umat beragama di dalam Risala-I Nur? kedua bagaimana sosiohistoris kehidupan Said An-Nursi? dan apa relevansinya dengan perkembangan gerakan Dakwah lintas Iman di Indonesia? Dengan pendekatan konten analisis untuk mendeskripsikan pandangan kebragamaan dan dakwah lintas iman dalam pandangan Said Nursi di dalam kitab Risala-i Nur dan pendekatan sejarah untuk mengkaji biografi kehidupan Said an-Nursi, serta mencoba mencari simpul hubungan dengan gerakan Dakwah Lintas Iman di Indonesia, penelitian ini menghasilkan beberapa point penting pertama, mendeskripsikan pemikrian Said Nursi tentang konsep Dakwah Lintas Iman, dalam karya Risala-i Nur dan kedua biografi Said Nursi sebgai pembacaan sosiohistoris kehidupan Said Nursi, dan ketiga mengetahui relevansi konsep dakwah lintas Iman Said Nursi dengan dakwah lintas iman di Indonesia.
Telaah Buku: Membela Islam, Membela Kemanusiaan
Authors: Wiranto Erham B. 
Published: August 2024

Judul : Membela Islam, Membela KemanusiaanPenulis : Fajar Riza Ul HaqPenerbit : Mizan, BandungTahun : 2017Jumlah Halaman : xviii, 287 halaman
Religiusitas Masyarakat Islam Pesisir: Studi tentang Perilaku Religi Masyarakat Hena Lima Kecamatan Leihitu Kabupaten Maluku Tengah
Authors: Soulisa M. Syafin 
Published: August 2024

Manusia pada hakekatnya selalu ingin memenuhi kebutuhan hidupnya, baik kebutuhan material (jasmani) maupun spiritual (rohani). Kebutuhan spiritual tersebut menyebabkan segala kelakuan manusia menjadi serba religi, sehingga menyebabkan serba keramat, baik pada perilaku manusia itu sendiri, maupun tempat dimana perilaku manusia itu dilakukan untuk dilaksanakan. Sikap religi tersebut selalu diwujudkan oleh masyarakat dalam bentuk upacara-upacara keagamaan. Penelitian ini bertujuan untuk mengetahui perilaku religi masyarakat Negeri Hena Lima di pesisir utara pulau Ambon-Maluku. Dalam menganalisis data yang ada, penulis menggunakan metode kualitatif, teknik analisis yang digunakan adalah deskriptif kualitatif. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa perilaku keagamaan masyarakat Negeri Hena Lima adalah perilaku yang berhubungan dengan keyakinan religi tentang leluhur yang dianggap memiliki keistimewaan dan senantiasa dihormati, karena selalu hidup bersama mereka dan diyakini dapat mempengaruhi kehidupan masyarakat. Adapun bentuk-bentuk perilaku religi Masyarakat Negeri Hena Lima yang diwujudkan dalam Sistem Upacara-upacara religi yakni Tahalil (upacara religi dalam rangka memberi makan arwah para leluhur yang di padukan dengan nilai Islam), Aroha (upacara religi-keagamaan yang dilaksanakan setiap tanggal 10 hingga 12 Rabiul Awal untuk mengenang jasa para leluhur), Pataniti, (proses pemanggilan arwah leluhur untuk mendampingi mereka yang berhajat baik pada saat susah maupun senang), Hulasi (pengobatan tradisional dengan cara menyebutkan nama para leluhur ketika ada yang jatuh sakit yang diyakini terdapat campur tangan para leluhur) Pakatati (Proses upacara yang dilaksanakan pada saat anak berumur 30-40 hari), Tanahu’a (upacara yang di laksanakan untuk memotong rambut bayi), Jara Baliwe (tradisi menziarahi kuburan karamat leluhur yang dirangkai dengan upacara religi).
Pengaplikasian Pola Computer Mediated Communication (CMC) dalam Dakwah
Authors: Arnus Sri Hadijah 
Published: August 2024

Seiring kemajuan teknologi, dunia komunikasi dan informasi diperkuat oleh hadirnya media baru (smartphone, PDA, laptop, dll), yang berbasis internet. Media tersebut memungkinkan setiap orang melakukan komunikasi lebih mudah, lebih interaktif, dan tidak lagi dibatasi oleh ruang dan waktu. Fenomena penggunaan media online dalam mengakses berita dan membangun komunikasi interpersonal melalui media jejaring sosial melahirkan suatu konsep baru dalam komunikasi yaitu CMC (computer mediated communications). Hal ini menarik bagi penulis untuk menerapkan pola CMC dalam bidang dakwah untuk lebih menpermudah aktivitas dakwah untuk lebih memperluas khalayak. Dari hasil penelitian, diketahui bahwa pengaplikasian pola CMC`dalam berdakwah ditemukan beberapa kendala, seperti kurangnya penggunaan isyarat nonverbal dalam pola tersebut. Melalui media online, isyarat nonverbal juga hampir tidak ada, sebelum akhirnya muncul teknologi yang membuat suasana komunikasi face to face melalui media online. Di satu sisi teknologi ini dapat mempererat hubungan antar manusia, akan tetapi di sisi lain juga dapat menjauhkan hubungan antar person secara tatap muka langsung. Oleh karena itu, penerapan pola CMC ini sebenarnya hanya pelengkap metode dan media dakwah yang semestinya tidak menghilangkan metode face to face.
Study on the mechanism of liver cancer immune escape mediated by MINDY1 through regulation of PD-L1 ubiquitination level
Authors: Song Xingchao , Li Wenjin , Tian Chunyan , Ma Xiao , Yang Weibin , Zhou Jiahua 
Published: August 2024

The novel deubiquitinase enzyme, motif interacting with ubiquitin-containing novel DUB family-1 (MINDY1), is highly expressed in liver cancer tissues and plays a crucial role in maintaining the stemness of liver cancer cells. Programmed death ligand-1 (PD-L1) is an immunosuppressive molecule overexpressed by tumour cells. The potential role of MINDY1 in inhibiting the stemness of liver cancer cells by deubiquitinating PD-L1 has not yet been reported. To investigate the mechanism by which MINDY1 mediates immune escape in liver cancer through the regulation of PD-L1 ubiquitination, we examined the expression levels of MINDY1 and PD-L1 in liver cancer and adjacent tissues from 50 hepatocellular carcinoma (HCC) patients using protein imprinting and immunohistochemistry. We analyzed the relationship between the expression levels of MINDY1 and PD-L1 in liver cancer tissues and their correlation with the 5-year tumor-free survival rates of patients. Subsequently, MINDY1 expression was knocked down in Huh7 cells using small interfering RNA (siRNA) interference or upregulated through transfection with a MINDY1 overexpression plasmid. The effects of MINDY1 knockdown or overexpression on the proliferation, apoptosis, migration, and invasion of HCC cells, as well as the regulation of PD-L1 binding and ubiquitination, were assessed. The 5-year tumor-free survival rates were significantly lower in both the high MINDY1 expression group and the high PD-L1 expression group (χ2 = 4.919 and 13.158, respectively). A significant difference in survival was observed between the high and low MINDY1 expression groups (χ2= 27.415). MINDY1 was found to directly interact with PD-L1, with MINDY1 gene knockdown promoting PD-L1 ubiquitination and MINDY1 overexpression inhibiting PD-L1 ubiquitination. All comparisons yielded statistically significant results (P < 0.05). In conclusion, MINDY1 inhibits the malignant progression of liver cancer by inhibiting PD-L1 ubiquitination and mediating immune escape.