bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsiveness of Brca1 and Trp53 Deficiency–Induced Mammary Preneoplasia to Selective Estrogen Modulators versus an Aromatase Inhibitor in Mus musculus
Authors: Alothman Sahar J. , Wang Weisheng , Goerlitz David S. , Islam Md , Zhong Xiaogang , Kishore Archana , Azhar Redha I. , Kallakury Bhaskar V. , Furth Priscilla A. 
Published: March 2017

Abstract
An intervention study initiated at age 4 months compared the impact of tamoxifen (25 mg), raloxifene (22.5 mg), and letrozole (2.5 mg) administered by 60-day release subcutaneous pellet on mammary preneoplasia prevalence at age 6 months in conditional genetically engineered mouse models with different Breast cancer 1 (Brca1) gene dosages targeted to mammary epithelial cells and germline Tumor protein P53 (Trp53) haploinsufficiency (10–16/cohort). The proportion of unexposed control mice demonstrating mammary preneoplasia at age 6 months was highest in Brca1fl11/fl11/Cre/p53−/+ (54%) mice followed by Brca1WT/fl11/Cre/p53−/+ mice (30%). By age 12 months, invasive mammary cancers appeared in 80% of Brca1fl11/fl11/Cre/p53−/+and 42% of Brca1WT/fl11/Cre/p53−/+control unexposed mice. The spectrum of cancer histology was similar in both models without somatic mutation of the nongenetically engineered Brca1, Trp53, Brca2, or Death-associated protein kinase 3 (Dapk3) alleles. Two-month exposure to tamoxifen, raloxifene, and letrozole significantly reduced estrogen-mediated tertiary branching by 65%, 71%, and 78%, respectively, in Brca1fl11/fl11/Cre/p53−/+mice at age 6 months. However, only letrozole significantly reduced hyperplastic alveolar nodules (HAN) prevalence (by 52%) and number (by 30%) and invasive cancer appeared despite tamoxifen exposure. In contrast, tamoxifen significantly reduced HAN number by 95% in Brca1WT/fl11/Cre/p53−/+ mice. Control mice with varying combinations of the different genetically modified alleles and MMTV-Cre transgene demonstrated that the combination of Brca1 insufficiency and Trp53 haploinsufficiency was required for appearance of preneoplasia and no individual genetic alteration confounded the response to tamoxifen. In summary, although specific antihormonal approaches showed effectiveness, with Brca1 gene dosage implicated as a possible modifying variable, more effective chemopreventive approaches for Brca1 mutation–induced cancer may require alternative and/or additional agents. Cancer Prev Res; 10(4); 244–54. ©2017 AACR.
3‐D computer modelling of malunited posterior malleolar fractures: effect of fragment size and offset on ankle stability, contact pressure and pattern
Authors: Alonso‐Rasgado Teresa , Jimenez‐Cruz David , Karski Michael 
Published: March 2017

AbstractBackgroundThe positioning of the fracture fragment of a posterior malleolus fracture is critical to healing and a successful outcome as malunion of a posterior malleolar fracture, a condition seen in clinical practice, can affect the dynamics of the ankle joint, cause posterolateral rotational subluxation of the talus and ultimately lead to destruction of the joint. Current consensus is to employ anatomic reduction with internal fixation when the fragment size is larger than 25 to 33% of the tibial plafond.MethodsA 3‐dimensional finite element (FE) model of ankle was developed in order to investigate the effect of fragment size (6–15 mm) and offset (1–4 mm) of a malunited posterior malleolus on tibiotalar joint contact area, pressure, motion of joint and ligament forces. Three positions of the joint were simulated; neutral position, 20° dorsiflexion and 30° plantarflexion.ResultsCompared to the intact joint our model predicted that contact area was greater in all malunion scenarios considered. In general, the joint contact area was affected more by section length than section offset. In addition fibula contact area played a role in all the malunion cases.ConclusionsWe found no evidence to support the current consensus of fixing posterior malleolus fractures of greater than 25% of the tibial plafond. Our model predicted joint instability only with the highest level of fracture in a loaded limb at an extreme position of dorsiflexion. No increase of peak contact pressure as a result of malunion was predicted but contact pattern was modified. The results of our study support the view that in cases of posterior malleolar fracture, posttraumatic osteoarthritis occurs as a result of load on areas of cartilage not used to loading rather than an increase in contact pressure. Ankle repositioning resulted in increased force in two ankle ligaments. Our finding could explain commonly reported clinical observations.
MacroH2A histone variants maintain nuclear organization and heterochromatin architecture
Authors: Douet Julien , Corujo David , Malinverni Roberto , Renauld Justine , Sansoni Viola , Posavec Marjanović Melanija , Cantariño Neus , Valero Vanesa , Mongelard Fabien , Bouvet Philippe , Imhof Axel , Thiry Marc , Buschbeck Marcus 
Published: March 2017

ABSTRACT
Genetic loss-of-function studies on development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown mechanism. Here, we present results demonstrating that macroH2A variants have a major function in maintaining nuclear organization and heterochromatin architecture. Specifically, we find that a substantial amount of macroH2A is associated with heterochromatic repeat sequences. We further identify macroH2A on sites of interstitial heterochromatin decorated by histone H3 trimethylated on K9 (H3K9me3). Loss of macroH2A leads to major defects in nuclear organization, including reduced nuclear circularity, disruption of nucleoli and a global loss of dense heterochromatin. Domains formed by DNA repeat sequences are disorganized, expanded and fragmented, and mildly re-expressed when depleted of macroH2A. At the molecular level, we find that macroH2A is required for the interaction of repeat sequences with the nucleostructural protein lamin B1. Taken together, our results argue that a major function of macroH2A histone variants is to link nucleosome composition to higher-order chromatin architecture.
Chanel the bricoleur: Steal all the ideas you can
Authors: Taylor Dabrina , Jacob John 
Published: March 2017

Abstract
Although she is arguably regarded as France’s most celebrated designer, Chanel did not train within the classical Parisian haute couture system. This article examines the onetime milliner and couture interloper as a bricoleur, a female ‘handyman’ who made do with materials at hand to create something new (Claude Levi-Strauss 1966). In the earliest years of her career, Chanel’s transformative ‘making do’ centred on her appropriations of garments and styles that were coded masculine, and these masculine borrowings were foundational in the development of an easily copied Chanel feminine aesthetic – most notably apparent in the little black dress – that was suitable for women’s entrée into modernity’s heretofore male-identified public sphere. The discussion highlights the role of fashion appropriation in negotiating the gender tensions and ambiguities associated with women’s emergence into early twentieth-century life, considering the special case of fashion diffusion that occurs when members of a less-powerful group emulate and appropriate styles from those who are more privileged.
Appropriation, articulation and authentication in Acid House: The evolution of women’s fashion throughout the early years (1987–1988) of the Acid House culture
Authors: Tierney Tara 
Published: March 2017

Abstract
The purpose of this article is to explore how ‘dress’ from the 1960s’ American Hippy movement was appropriated and adapted by women in the ‘British Acid House’ music culture. The emergence of ‘Acid House’ transformed nightclubs from ‘places for drinking and looking good but not for dancing’, into a space where ravers would dance through the night fuelled by the drug, ecstasy. These changes manifested in a number of ways, most notably, through transformation of outward appearance, which included appropriation of the Hippy movement and ‘First Summer of Love’ in 1967. Similarities between Acid House and the Hippy culture were so akin that this early period of House music became known as ‘The Second Summer of Love’.
Vlisco: Made in Holland, adorned in West Africa, (re)appropriated as Dutch design
Authors: Bruggeman Danielle 
Published: March 2017

Abstract
While the idea of ‘Africa’ is sometimes a source of inspiration for brands and designers aimed at the western market, the colourful wax prints by the Dutch company Vlisco were historically made for West and Central African consumers. These fabrics, designed and produced in the Netherlands, have become interconnected with African culture and identity. Established in 1846, the company Vlisco focused on the Dutch East Indies and later West and Central Africa as its export markets. Yet today, Vlisco is playing an increasing role in western fashion, art and design. Moreover, Vlisco has recently collaborated with renowned Dutch designers such as Viktor&Rolf, actively (re)appropriating the wax printed fashion fabrics as Dutch. In this article I explore the multiple layers of cultural (re)appropriation, and the deep-rooted ‘cultural hybridity’, underlying Vlisco’s wax printed fashion fabrics. The most recent form of cultural (re)appropriation is the way in which Vlisco presents itself within the context of Dutch design. In this article I focus on the hybrid cultural dynamics underlying the performance of Africanity – and recent Dutchness – through the use of Vlisco’s fabrics in the context of today’s globalized fashion system.
Dreaded culture: The appropriation of a culture of resistance in Aotearoa New Zealand
Authors: Richards Harriette 
Published: March 2017

Abstract
In Subculture: The Meaning of Style ([1979] 1988), Dick Hebdige noted that ‘somewhere between Trenchtown and Ladbroke Grove the cult of Rastafari had become a “style”: an expressive combination of “locks,” of khaki camouflage and “weed”’. For cultures of resistance such as Rastafari, aesthetic determinants are more than simple visually identifying features. Rather, these elements are the foundation of unity, a shared aesthetic that points to a shared world-view, a shared consciousness or livity. However, in the processes of cultural appropriation, the significance of such aesthetic qualities are often entirely re-determined. This article considers the cultural appropriation of Rastafari in the context of Aotearoa New Zealand in order to reflect upon the intricate ways in which the aesthetic elements of culture play into the processes of appropriation. In so doing, this article illustrates the contradictions and ambiguities involved in processes of cultural appropriation and suggests that such processes be considered in relation to their contextual adoption, rather than by way of simple reductionist binaries.
Relationship between newborn mid-upper-arm circumference and birth weight
Authors: Taufiq Muhammad Anwar , Madjid Djauriah A. , Lisal J. S. , Daud Dasril 
Published: March 2017

Background Recording an accurate birth weight by primaryhealth care workers has been a problem in rural areas, leadingto a search for an alternative, inexpensive, age independent andnoninvasive method to predict neonatal well being. Mid-upper-armcircumference (MUAC) might be an alternative anthropometricmeasurement useful to estimate the state of nutrition.Objective To evaluate the relationship between MUAC andbirth weight in low birth weight (LBW) and normal birth weight(NBW) infants.Methods We measured birth weight and MUAC of newbornbabies of various gestational ages at Siti Fatimah Maternity andChildren's Hospital and Dr. Wahidin Sudirohusodo GeneralHospital, Makassar, South Sulawesi, Indonesia. Correlationtests and diagnostic accuracy using different cut-off points wereperformedResults There were 892 live birth newborns (117 LBW and 775NBW) included in the study. The sensitivity, specificity, positivepredictive value, and negative value for MUACs of< 10.3 em were94.9 %, 99.9%, 99.1%, and 99.2%, respectively. The sensitivity,specificity, positive predictive value, and negative value for MUAC< 10.4 em were 99.1 %, 99.6%, 97.5%, and 99.9%, respectively.The sensitivity, specificity, positive predictive value, and negativevalue for MUAC < 10.5 em were 100%,99.4%, 95.9%, and 100%,respectively.Conclusion There is a strong correlation between MUAC andbirth weight. Birth weight can be predicted with the followingequation: Birth weight= -1776.383 + (416.95 newborn MUACvalue). The optimal cut-off point for the newborn MUAC value forLBW infants is< 10.5 em.
Comparison of blood glucose levels in breastfed vs. formula-fed low birth weight infants
Authors: Pangaribuan Eli Tua , Lubis Bugis M. , Sianturi Pertin , Azlin Emil , Tjipta Guslihan D. 
Published: March 2017

Background Low birth weight infants are defined as babies withbirth weight less than 2500 grams. Low birth weight infants tendto suffer from hypoglycemia compared to full term infants. Theincidence of hypoglycemia in newborns varies between 1.3 and 3per 1000 live births. Blood glucose levels in formula-fed infantsare lower than those in breastfed infants.Objective To compare blood glucose levels in breastfed andformula-fed low birth weight infants.Methods A cross sectional study was conducted between February2007 and June 2007 at Pirngadi and H. Adam Malik GeneralHospital in Medan, North Sumatra, Indonesia. All low birthweight babies were classified into two groups: the breastfed andformula-fed. Each group consisted of 32 infants. Capillary bloodwas collected using heel pricks at 1, 48, and 72 hours after birth,and plasma glucose was evaluated using the Glucotrend2 bloodglucose test.Results The breastfed low birth weight infants had significantlyhigher blood glucose levels (P=0.002) than formula-fed low birthweight infants. Mode of delivery was related to blood glucose level.Infant delivered by caesarean section had significantly differentblood glucose levels at 1 hour (P=0.005) and 72 hours afterbirth (P=0.027). The full-term infants had significantly higherblood glucose level (P=0.007) than the small for gestational ageinfants.Conclusions Generally, low birth weight infants have hypoglycemiaafter first hour of delivery. Breastfed low birth weight infants havehigher blood glucose levels than formula-fed low birth weightinfants.
Critical site differences of fusion protein between wildtype and vaccine measles virus strains in Indonesia
Authors: Setiawan Made , Sjahrurachman Agus , Ibrahim Fera , Suwandono Agus 
Published: March 2017

Background Measles virus can cause high morbidity and mortality in infants and children. Fusion glycoprotein (F protein) found in the viral envelope is important for the host cell infection mechanism. F protein is immunogenic and may cause specific immune responses in the host. High variability is found in the F protein gene of vaccine viral strains compared to 'Wild type strains. This amino add sequence variability may result in a less specific immune response against other strains, possibly rendering thevaccine to be less effective.Objective To detennine the amino add sequence differences in critical sites of F protein in Mld type and vaccine measles virus strains in Indonesia.Methods We compared amino acid sequences of three genotypes of Mld type measles virus (02, 03 and D9) to those of the vaccine strains, CAM􀀸 70, Schwarz, and Edmonston􀀸wt type measles virus.Resul ts Analysis showed that there were differences at Fl􀀸F2 cleavage site, B cell epitopes, and H protein binding site between the CAM􀀸70 vaccine viral strains and Mld type strains. Schwarz vaccine strain differed from the wild type strains at the H protein binding site. A 03 wild type strain potential glycosylation site was also different from all other strains studied.Conclusion There were differences in the critical sites of F protein between Mld type strains and the CAM􀀸70 and Schwarz vaccine strains.
Effect of zinc supplementation on morbidity among stunted children in Indonesia
Authors: Siregar Rustam , Lilisianawati Lilisianawati , Lestari Endang Dewi , Salimo Harsono 
Published: March 2017

Background The Indonesian Health Ministry reported that 35 .6% of Indonesian children and up to 50% in certain regions have stunted growth. They are at high risk of chronic zinc deficiency. Inadequate zinc intake may result in an impaired immune sy stem and high incidence of morbidity. Zinc supplementation is knO\Vll to improve immune status thus reducing the incidence of morbidity among stunted children.Objective To evaluate the effects of zinc supplementation on morbidity incidence among stunted Indonesian school children. Methods We evaluated the effects of daily zinc supplementation (2.38 mg of zinc􀁇supplemented milk) on the incidence of diarrhea, respiratory infections, and fever in a double􀁇blind, randomized, controlled trial in 169 stunted children (zinc􀁇supplemented n=84; placebo n=85) aged 7 to 9 years in Jakarta and Solo. Zincsupplementation and morbidity surveillance were perfonned for 6 months.Results Compared to the first 3 months of intervention, zinc supplementation resulted in a reduction in the incidence of diarrhea, respiratory infections, and fever during the second three months (by 67%, 42%, and 30%, respectively). Children from the zinc􀁇supplemented group tended to have a lower episodic incidence of diarrhea and fever than those from the placebo group, although neither of these differences was statistically significant (P< 0.45,95% CI 0.63 to 0.89).Conclusion Zinc supplementation has no significant effect in reducing the incidence of diarrhea, respiratory infections, and fever in stunted children although tended to have a lower episodic incidence.
Combining a fuzzy inference system with an A* algorithm for the automated generation of roadmaps for Automated Guided Vehicles
Authors: Uttendorf Sarah , Eilert Björn , Overmeyer Ludger 
Published: March 2017

Abstract
This paper proposes a method for the automated generation of roadmaps for AGVs. So far the roadmaps are mostly generated
manually, which leads to long and laborious planning phases. The presented method incorporates both mathematical roadmap
algorithms as well as human knowledge in the form of a fuzzy inference system. The results of the expert system are
evaluated in comparisons to the A* algorithm and to manually generated roadmaps on a real production layout. In both cases
the expert system performs better.
The Trans-Pacific Partnership
Authors: Voon Tania , Sheargold Elizabeth 
Published: March 2017

Abstract
This article provides an overview of the recently concluded Trans-Pacific Partnership Agreement (TPP), a treaty the parties have described as comprehensive and ambitious, yet also representing a balance of competing interests. The article focuses on the TPP’s chapters relating to investment, services, intellectual property and regulatory coherence, each of which provides insight into the motivations that drove the conclusion of the TPP and the negotiating dynamics that determined its final content. In areas such as investment, the TPP takes a more balanced approach than many earlier agreements, providing greater safeguards for the regulatory autonomy of states while still embodying core protections for foreign investors. In relation to intellectual property and services, the TPP goes beyond earlier agreements in several key respects, such as preventing the imposition of local presence requirements for service providers or requiring longer copyright terms than those demanded by other international treaties. The TPP chapter on regulatory coherence is one of the most novel features of the treaty, as regulatory coherence is not frequently included in earlier trade agreements, demonstrating the increased focus of states on addressing regulatory barriers to trade and investment. While all of these elements of the TPP are interesting in their own right, given the number and size of the parties involved in the agreement, they also provide valuable guidance about the direction of other ongoing and future preferential trade agreement negotiations, such as the proposed Transatlantic Trade and Investment Partnership (TTIP) and Trade in Services Agreement (TiSA).
Dispute Settlement Mechanisms in U.S. FTAs with Korea, Panama, Peru and Colombia: Basic Designs, Key Characteristics and Implications
Authors: Lee Jaemin 
Published: March 2017

Abstract
The United States concluded free trade agreements (FTAs) with Korea, Peru, Panama and Colombia in late 2000s. Since the four FTAs were negotiated and concluded largely contemporaneously, key traits and characteristics of the agreements are similarly formulated. In light of this, dispute settlement mechanisms (state-to-state dispute settlement proceedings, investor-state dispute settlement proceedings, and Joint Committees) of the four FTAs also share commonalities. At the same time, new ideas and suggestions are explored in the four FTAs. While issues and disputes under the four FTAs have arguably not been ripe for the constitution of dispute settlement proceedings under the FTAs at the moment, sooner or later they are likely to end up in the dockets of the respective proceedings. The key elements of the four FTAs’ dispute settlement mechanisms are also adopted in other FTAs that the United States have concluded afterwards including most recently the Trans-Pacific Partnership, since these elements are reflective of the general scheme of the United States in their FTAs. What remains to be seen is how the general scheme of dispute settlement proceedings can be applied and implemented in actual settings when the FTAs produce increasing numbers of disputes in the future. In particular, marked disparity in human and financial resources between the United States and the four FTA’s parties may bring about disparate impacts and consequences among contracting parties. Continued attention needs to be paid to the development concerning implementation of the four FTAs, in particular their dispute settlement proceedings.
Technical and clinical validation of the Greiner FC-Mix glycaemia tube
Authors: van der Hagen Eline A.E. , Fokkert Marion J. , Kleefman Amanda M.D. , Thelen Marc H.M. , van den Berg Sjoerd A.A. , Slingerland Robbert J. 
Published: March 2017

AbstractBackground:Measurement of adequate glucose concentrations is complicated by in vitro breakdown of glucose due to glycolysis. Unlike the commonly used NaF-EDTA and NaF-oxalate phlebotomy tubes, citrated NaF-EDTA tubes are reported to directly and thereby completely inhibit glycolysis. Recently, Greiner introduced the VacuetteMethods:The FC-Mix tube was tested against the WHO recommended method of optimal laboratory conditions, both in healthy volunteers and pregnant woman undergoing oral glucose tolerance test (oGTT) for screening of gestational diabetes mellitus (GDM). Glucose concentrations were measured after different incubation times (0–48 h) and temperatures (room temperature, 37 °C), both in uncentrifuged whole blood and centrifuged material.Results:Deming regression analysis shows that glucose concentrations measured in the FC-Mix tube correlate to the WHO recommended method. Stability is maintained at room temperature for 48 h and at least 24 h at 37 °C. The use of the FC-Mix tube was also validated in screening for GDM and proved comparable to the WHO recommended method in diagnostic outcome.Conclusions:The new Greiner FC-Mix tube combines the easy handling of a routine tube with dry additive with the ability to immediately inhibit glycolysis as in the WHO method for optimal pre-analytical and analytical conditions and performs equally to those conditions when screening for GDM.