bluuebunny/crossref_metadata_2025_split huggingface dataset:
FIRST EXPERIENCE IN SYSTEMIC ADMINISTRATION OF EVEROLIMUS IN RENAL TRANSPLANTATION FROM EXPANDED CRITERIA DONORS IN RUSSIAN FEDERATION
Authors: Uliyankina I. V. , Skvortsov A. E. , Ananiev A. N. , Kutenkov A. A. , Kuzmin D. O. , Daineko V. S. , Gogolev D. V. , Reznik O. N. 
Published: January 2017

Introduction. Kidney transplant (KTx) with reduced functional reserve is more sensitive to the toxic effects of calcineurin inhibitors (CNI). Immunosuppressive therapy (IST) approach with m-TOR inhibitors in case of KTx from expanded criteria donors (ECD) leads to decreasing levels of cyclosporine (CsA) in the blood. Despite the presence of international pilot studies we do not have yet clear recommendation as to combination of CsA and Everolimus. In this article, we presented 5-year results of the fi rst Russian experience of systematic administration of Everolimus as a basic IST in KTx from ECDs.Materials and methods.The group of recipients (n = 41) having received bilateral kidney transplants from the same ECDs was analyzed. Comparison group (n = 19) received standard IST consisting of CsA, MMF and steroids. Study group included 22 recipients who received kidneys from the same ECDs and IST based on early (starting from the 90th day after transplantation) conversion from MMF to Everolimus – 1.5 mg/day (target concentration – 3–6 ng/mL). Simultaneously with the administration of Everolimus, dosing of Neoral dropped immediately by 50%, and then, in accordance with the target concentration (C0 30–50 ng/mL). Dosage of steroids in patients of the study group was gradually minimized.Results.Both groups were comparable in terms of serum creatinine level and glomerular fi ltration rate (GFR) up to 3 months after transplantation. As a result of the introduction of a new IST scheme in the study group, serum creatinine level in 60 months after KTx was 149.27 ± 42.68 μmol/L, in the comparison group – 209.87 ± 39.56 μmol/L; р < 0.05. In the control group GFR reduced to 27.50 ± 7.39 mL/min/1.73 m2, in the study group it was 46.21 ± 15.17 mL/min/1.73 m2, p < 0.05.Conclusion.Early administration of Everolimus is strongly recommended in all cases of ECD KTx. This approach helps minimize CNI nephrotoxicity, provides the prevention of chronic allograft nephropathy, enables the stable renal function, and contributes to the survival of renal transplant recipients.
MICRONEEDLES AS A WAY TO INCREASE THE TRANSDERMAL INSULIN DELIVERY
Authors: Kuznetsova E. G. , Ryzhikova V. A. , Salomatina L. A. , Tukmachev V. A. , Sevastianov V. I. 
Published: January 2017

Aim: to prove the possibility of increasing the diffusion of insulin through the skin in vitro with pre-applying microneedles.Materials and methods. Microemulsion for transdermal therapeutic system of insulin has been used in vitro studies. Genetically engineered human insulin has been used in this research. Applicators with silicon microneedles (40 and 150 microns long) have been used to enhance the diffusion fl ux of drug substance. The dynamics of insulin release from the transdermal therapeutic systems through the rabbit skin has been studied in glass Franz diffusion cells in analyzer diffusion of drugs HDT 1000 (Copley Scientifi c Ltd., UK). Insulin has been labeled with fl uorescein isothiocyanate to separate the insulin absorption spectrum from the spectra of native skin proteins at spectrophotometer measurements.Results. The amounts of insulin delivered through the skin in vitro after previous application of microneedles of 40 and 150 microns are 282.5 ± 61.1 and 372.3 ± 7.0 microgram, respectively. This is 1.4 and 1.9 times more than in the transdermal system without microneedles.Conclusion.The conditions for increasing the diffusion of insulin through the skin in a model transdermal therapeutic system with microneedles (length – 150 microns, duration of pre-application – 1 hour) have been found.
THE EXPERIMENTAL MODEL OF DISC-PUMP FOR MECHANICAL CIRCULATORY SUPPORT
Authors: Chernyavskiy A. M. , Ruzmatov T. M. , Fomichev A. V. , Medvedev A. E. , Prikhodko Y. M. , Fomin V. M. , Fomichev V. P. , Chekhov V. P. 
Published: January 2017

The relevance of the use of circulatory support systems for the treatment of chronic heart failure (CHF) has increased over the recent years. Up to 20% of the patients from the waiting list for a donor heart die each year before they could get one. In our country, there is a huge need for mechanical heart support systems. However, the acquisition of foreign systems is associated with the excessive fi nancial costs. In addition, nowadays, there is no system that would meet all medical and technical requirements in full, and at the same time, would be of high safety for the patient. Therefore, research on the development of the systems of auxiliary circulation is highly relevant and is in demand in our country. One of the promising directions in this fi eld is disk pumps of viscous friction, which are based on the operation principle of Tesla disk pump. This article describes the creation and operation of the current model of the disk pump. The results of the bench tests confirmed that the expendable pressure characteristics of our disk pump are capable of providing the necessary parameters of blood circulation. The findings confi rm the perspective of the selected research area and provide the basis for further development and testing of this model of pump.
Helium Implantation into JSC-1A Lunar Simulant for Volatile Extraction System Testing
Authors: Olson Aaron 
Published: January 2017

Research is ongoing to develop an experimental volatiles extraction system that can demonstrate a heating process for releasing helium-3 (3He) and other valuable lunar volatiles from lunar regolith. Beyond the Apollo and Luna program lunar samples, there is no regolith or regolith simulant implanted with solar wind volatiles that is available. A device, named the Solar Wind Implanter (SWIM), has been developed to implant helium into batches of JSC-1A simulant.Â It uses a voltage difference between planar electrodes to accelerate helium ions (up to the average solar-wind speed of 450 km/s) into a thin, falling sheet of regolith simulant. Initial implantation tests have been conducted and SWIM is being calibrated by performing tests to determine electrode current under varying operational parameters and by measuring the dose and temperature release pattern of helium in implanted samples.
Development of a Superconducting Heat Switch for an Ideal Integrating Bolometer
Authors: Mok Mason 
Published: January 2017

Improving the sensitivity of current state-of-the-art bolometers is essential for future cosmology endeavors. Having a bolometer that is thermally isolated from its thermal sink is ideal in order to reduce phonon noise: the factor limiting bolometer sensitivity. To thermally isolate a bolometer as much as possible a pixel-scale superconducting heat switch is being developed to control the conductance between a bolometer and its thermal sink. The heat switch is comprised of a superconducting thin aluminum film surrounded by a niobium coil. Current is passed through the coil and the resulting magnetic field drives the aluminum into its high conductance normal state. Experimental data agrees well with the results of a thermal model of the device.Â Â
Efficacy and safety of 70% glycolic acid versus Q Switched Nd:YAG laser in the treatment of melasma: acomparative study
Authors: Narasimhan Murali , K. G. Divya , V. Rajagopalan , B. Parveen 
Published: February 2017

<p><strong>Background: </strong>Melasma is an acquired hypermelanosis characterized by light-to-deep brown pigmentation over cheeks, forehead, upper lip, and nose. Treatment of this condition is difficult and associated with high recurrence rates. Among newer therapies, there is interest in the use of glycolic acid peels and Q-switched Nd:YAG laser (QSNYL). The aim of the present study was to compare the therapeutic efficacy and in melasma. </p><p><strong>Methods:</strong> 60 patients of melasma were included. They were randomly divided in two groups (Group A = 30 patients treated with glycolic acid and Group B = 30 patients treated with QSNYL). Out of the 60 patients included, 26 patients in Group A, 24 patients in Group B completed the study. Response to treatment was assessed using MASI scores. </p><p><strong>Results: </strong>The peak incidence of melasma was seen in the age group 31-40 years. Female preponderance was seen in the study (F: M-6.6:1). Sunlight was the common aggravating factor in both the groups (30%). Malar type was the most common (51.7%) observed in both the groups. MASI scores improved from 7.14 to 4.99 with glycolic acid peel and from 6.17 to 4.67 in the laser group at the end of the study. The common adverse effect observed in the study was erythema in both the groups. Postinflammatory hyperpigmentation was frequent in laser treated patients.</p><p><strong>Conclusion:</strong> 70% Glycolic peels were better than Q switched Nd:YAG laser for the treatment of melasma. Among patients treated with laser postinflammatory hyperpigmentation was a significant side effect especially in darker skin types.</p>
The Pear Violin by B. Zhao
Authors: Borle Sean 
Published: January 2017

Zhao, Bingbo. The Pear Violin, illustrated by Gumi. Starfish Bay Children’s Books, 2016.Bingbo Zhao, who publishes under his first name, Bingbo, has published more than 370 children’s books and won more than 50 awards. The Pear Violin is an imaginative picture book which starts from the idea that pears and violins are shaped alike. In Bingbo’s fantasy world, a squirrel cuts a pear in half, uses a twig and some of his whiskers to make a bow, and begins playing. In this world foxes, elephants, bears, lions and a variety of other animals all inhabit the same forest. The music of the violin is so powerful that it can make the fox stop chasing the chicken and the lion “let the rabbit lie in his arms, so that the rabbit would feel warmer when listening to the music.” The music also has the power to make a small pear seed grow quickly into a tree and grow many pears. All the animals make the pears into cellos, violins and violas and all play beautiful music together. Throughout the book Gumi (no last name given) illustrates the motion and emotion of the animals. The animals’ faces show curiosity when the seed starts to grow and excitement when they play together in the concert. A suspension of disbelief is required for the enjoyment of this book. Some children will ask, “Why don’t the pears rot?” and “Why are bears and elephants in the same forest?” However, for most, it will just be a fun book which carries the message that music brings people together. This book would be good for public libraries and school libraries.Recommended: 3 stars out of 4Reviewer: Sean BorleSean Borle is a University of Alberta undergraduate student who is an advocate for child health and safety
Sea Change by F. Viva
Authors: Flanders Tammy 
Published: January 2017

Viva, Frank. Sea Change. Toon Books, 2016.What kid ever wants to be shipped off to some old relative’s place for the summer? Well, if you read any juvenile literature the answer is, of course, almost none. And Eliot is no exception.At first glance, Point Aconi, Nova Scotia does seem an unlikely place to have the ‘great time’ that Eliot’s mother claims he’ll have. There’s the offhanded old great-uncle and his mangy old dog, a rag-tag bunch of kids, some who have issues, the very unappealing food (tongue and onions or pickled pigs feet) and having to work on a fishing boat, all of which seem like a nightmare come to life.But, as in most of these kinds of novels, Eliot comes to love and appreciate the unique locale, care about the quirky kids who live there, and adapt to local ways. His growing maturity is evident when he takes on a local bully and helps him get a job. He also figures out the best way to help his new best friend, Beth, who is being physically abused by her father.Despite the predictability of some of the storylines, the strengths of the story are found in the strong sense of place and the various characters who live there. Viva is an author, illustrator and designer with several picture books to his credit and certainly, the quality of the book’s production is high with many artsy, retro-style illustrations and text formatting that is reminiscent of concrete poetry. The text flows and bends to highlight Eliot’s thoughts and observations, making the book all that more interesting.This short illustrated novel should find an audience with middle grade readers who like stories with interesting characters. The Canadian context makes this attractive for classroom use, too.Recommended: 3 out of 4 starsReview: Tammy FlandersTammy is the Reference Coordinator in the Doucette Library of Teaching Resources at the University of Calgary. She also reviews juvenile resources with an eye to classroom use in her blog, Apples with Many Seeds.
Simone in Australia by A. Cheng
Authors: Pow Virginia 
Published: January 2017

Cheng, Ardis. Simone in Australia. Paper Bear, 2016.Once in a while you find a book that your children will not stop asking you to read to them. Meet Simone in Australia. This delightfully illustrated book by Ardis Cheng, a local Calgarian author currently residing in Melbourne Australia - leaves nothing out. On each of the pages of Simone’s adventure with Jack, there is a new visual delight. The story takes us through the different flora and fauna of the Australian region Jack calls home; we meet spiders in Jack's house, adventure down to the beach and enjoy the tiny fairy penguins. The illustrations of animals of Australia including the kookaburra, echidna and wombat are a favorite page in our house. Simone, is a delightful young girl who is visiting her friend Jack. Throughout story Jack and Simone are given the challenge of explaining similarities and differences between Jack’s home and Simone’s. The book does an amazing job of highlighting what travel is for. To learn about new places and people. Often in the story, Simone will mention what she used to and while Jack teaching her about his home. This contrast is done very well, and makes sure to never state one is better -- just that they are different. Simone in Australia is also lovely way of explaining travel to children in a manner that allows them to understand how new and different can also be exciting, challenging and fun to share with a friend. This is a beautifully illustrated book that is great to read to children and children just starting to read themselves. It would be great addition to any personal or elementary school library.Highly Recommended: 4 stars out of 4Reviewer: Virginia PowVirginia is a Public Services Librarian at the Humanities and Social Science Library at the University of Alberta. When not reading to children, she enjoys being outdoors, running and stand up paddle boarding.
The Cranky Ballerina by E. Gravel
Authors: Gil Stephanie 
Published: January 2017

Gravel, Elise. The Cranky Ballerina. Katherine Tegen Books-Harper Collins Publishers, 2016.Ada is a cranky ballerina – she doesn’t like ballet! This picture book is written to encourage children to use their abilities in activities they enjoy, even though they may feel upset about not being good at activities in which their parents have enrolled them. The illustrations are attractive with many bright colors and details included, such as funny items or posters. Although they are not related to the dialogue or plot, children will enjoy spotting these fun details. The words change in size, color, font, and shape. This adds interest and accentuates the characters’ emotions. Because children aged 4 to 8, the intended audience, may have been enrolled by their parents in extra-curricular activities that they did not enjoy, they may be able to relate to this story. Not only does this story encourage children to refocus their negative emotions into finding activities they enjoy, but it can also be encouraging for parents. It can help parents to identify activities that will use a child’s apparent weaknesses as strengths and, in turn, improve the child’s mood. Other adults, such as teachers and instructors, will be reminded that every child has different strengths and abilities and that problems that they observe may be arising due to incompatible environments and activities.The characters portrayed as the ballet teacher and karate teacher are examples of patient and encouraging adults. The ballet teacher repeatedly tries to help Ada learn ballet, and the karate teacher compliments Ada on her spins and kicks. The ballet terms used, such as “plié”, “jetés”, and “arabesques”, would likely only be understood by children who have had ballet classes. Simple vocabulary, such as “spins” or “jumps” could have been used to make it easier to understand for children without prior knowledge in ballet. Overall, though, this picture book can be a good resource for teachers or parents and would be an interesting and a fun read for children. It should be available in school and public libraries.Highly Recommended: 4 stars out of 4Reviewer: Stephanie GilStephanie Gil is a University of Alberta student of linguistics who enjoys working with children and new immigrants. She spent a year teaching English as a Second Language in Japan to kindergarten and junior high school students.
One Bear Extraordinaire by J. McGowan
Authors: Borle Sean 
Published: January 2017

McGowan, Jayme. One Bear Extraordinaire. Abrams Books for Young Readers, 2015.This picture book is a story about a bear who begins the tale as a “one man band”, playing a guitar, drum, cymbals, harmonica and tambourine. Although legendary in the forest, he feels that, “something is missing”, so he sets out to find it. As he journeys, other animals join him, but none of them fill the void. Eventually the group encounters Wolf Pup, who wants to join but has no instrument. Bear offers him several of his instruments, but he just chews them. Finally, Wolf Pup howls at the moon and Bear realizes that what his song needed was a singer. In the end Bear just has his guitar left, but he has four other band members and their tune “sounded just right.” There are two music messages in this book. First, being a solo performer is fine, but making music with others is fine, too. The second message is that everyone has something to contribute, if they are just given a chance. McGowan’s technique for creating pictures is unusual. She builds up layers of paper, and then photographs the image. Children will enjoy identifying objects and creatures in the brightly coloured pictures. This is a good book and should be included in public libraries and school libraries.Recommended: 3 stars out of 4Reviewer: Sean BorleSean Borle is a University of Alberta undergraduate student who is an advocate for child health and safety.
The Darkest Dark by C. Hadfield & K. Fillion
Authors: Pearce Hanne 
Published: January 2017

Hadfield, C., & K. Fillion (2016). The Darkest Dark, illustrated by T. Fan and E. Fan. Tundra Books, 2016.The Darkest Dark takes us into the adventures of young Chris the astronaut. Together with his dog Albert, Chris is busy exploring Mars and saving the planet from aliens. Chris is so busy being an astronaut that he even has trouble sleeping at night, when the dark corners of his bedroom reveal aliens and monsters of all kinds. Chris’ parents are a bit dismayed that Chris cannot sleep in his own bed and they try a number of tricks to teach Chris that his bedroom is perfectly safe from aliens. Then on a July evening Chris and his family go to the neighbours to watch the most spectacular event: men landing on the moon. Witnessing this modern miracle Chris is so inspired that he finds himself changed, and no longer afraid of the dark. This touching story is based on the childhood of astronaut Chris Hadfield, the first Canadian to walk in space. Hadfield and Kate Fillion have captured a story that is simple in many respects, however singularly inspiring, as it shows how Chris grows to overcome his fears and to realize his dreams. The graphite illustrations by Terry and Eric Fan are remarkably rich in detail. The subtle colours and contrasting dark tones bring a young child’s imagination to life. The imagery of the Hadfield cabin on Stag Island at times seems so real you can almost hear the water lapping and the crickets in the distance. This would be an excellent book for young children between the ages of 4-12, especially those interested in space or experiencing fear of the dark. Parents can appreciate the lovely illustrations as well as the historical photos and factual information at the end of the book.Reviewer: Hanne PearceHighly recommended: 4 out of 4 starsHanne Pearce has worked at the University of Alberta Libraries since 2004. She has continuing interests in writing, photography and graphic design. She is currently working towards completing a Masters in Communications and Technology.
Saila & Betty by C. Rooney
Authors: Campbell Sandy 
Published: January 2017

Rooney, Christina. Saila & Betty, illustrated by Ali Hinch. Inhabit Education, 2016.Inhabit Education has launched a series of text levelled readers, called the Nunavummi Reading Series. Saila and Betty has been levelled using the Fountas & Pinnell Text Level Gradient Level: I, which makes it appropriate for upper level Grade 1. It is a picture book with two to three sentences per page including simple dialog. The sentences get progressively more difficult through the book. Ali Hinch’s comic-like artwork is black-line with bright colours for infill. The animals all show animation and emotions. While this is primarily a reading text, it contains a wellness message, as well. The story is a simple one about birds, who fly very well and seals, who swim very well discovering that while their strengths are different, and they are not very good at each other’s strengths at all, they can still be friends and have fun together. It is great to see curriculum materials being developed with Arctic themes. These will be very valuable learning tools in Arctic classrooms and as supplementary reading materials in southern classrooms. Highly recommended for elementary school libraries and public libraries. Highly Recommended: 4 stars out of 4Reviewer: Sandy CampbellSandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines. Sandy thinks that sharing books with children is one of the greatest gifts anyone can give.