bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Exercise-to-Rest Ratios on Physical and Physiological Performance During Hurling-Specific Small-Sided Games
Authors: Malone Shane , Hughes Brian , Collins Kieran 
Published: March 2017

Abstract
Malone, S, Hughes, B, and Collins, K. The influence of exercise-to-rest ratios on physical and physiological performance during hurling-specific small-sided games. J Strength Cond Res 33(1): 180–187, 2019—The current study examined the impact of different exercise-to-rest ratios on hurling-specific small-sided games (SSG). Thirty-four (n = 34) hurling players were monitored during an in-season training period. Heart rate (Polar Electro Oy, Kempele, Finland) and global positioning system technology (4-Hz; VX Sport, Lower Hutt, New Zealand) were used to analyze the physical and physiological differences between exercise-to-rest ratios across bouts of SSG. Total distance (m), high-speed distance (m) (≥17 km·h−1), very high-speed distance (≥22 km·h−1) (m), total accelerations (n), acceleration distance (m), peak velocity (km·h−1), and % maximum heart rate (%HRmax) were measured. Exercise-to-rest ratios of 2:1 (d = 0.65 ± 0.12; moderate), and 1:1 (d = 0.43 ± 0.12; small), resulted in significant reductions in high-speed distance, very high-speed distance, and acceleration distance. Exercise-to-rest ratios of 1:2 (d = 0.63 ± 0.21; moderate), and 1:3 (d = 1.23 ± 0.22; large), resulted in increased high-speed distance, very high-speed distance, and acceleration distance, but only after the third bout. The first bout of SSG resulted in the lowest %HRmax when compared with all other bouts (d = 0.63 ± 0.22; moderate). A significant bout-to-bout increase in %HRmax independent of exercise-to-rest ratio (d = 0.25 ± 0.04; small) was observed. Exercise-to-rest ratios of 2:1 (d = 0.65 ± 0.14; moderate), and 1:1 (d = 0.65 ± 0.24; moderate), resulted in significantly higher %HRmax during all SSG bouts; however, exercise-to-rest ratios of 1:2 (d = 0.25 ± 0.04; small), and 1:3 (d = 0.15 ± 0.04; trivial), resulted in lower %HRmax during SSG. Coaches should be aware that reducing the rest between bouts of SSGs (2:1 and 1:1 exercise-to-rest ratios) increases the physiological response (%HRmax) with reduced high-speed running performances. Coaches now have data to allow them tp best prepare for session needs with regard to specific SSG exercise-to-rest ratios.
Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease
Authors: Shaw Maureen A. , Gao Zhen , McElhinney Kathryn E. , Thornton Sherry , Flick Matthew J. , Lane Adam , Degen Jay L. , Ryu Jae Kyu , Akassoglou Katerina , Mullins Eric S. 
Published: March 2017

Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease of the CNS. Fibrinogen deposition at sites of blood–brain barrier breakdown is a prominent feature of neuroinflammatory disease and contributes to disease severity. Plasminogen, the primary fibrinolytic enzyme, also modifies inflammatory processes. We used a murine model of MS, experimental autoimmune encephalomyelitis (EAE), to evaluate the hypothesis that the loss of plasminogen would exacerbate neuroinflammatory disease. However, contrary to initial expectations, EAE-challenged plasminogen-deficient (Plg−) mice developed significantly delayed disease onset and reduced disease severity compared with wild-type (Plg+) mice. Similarly, pharmacologic inhibition of plasmin activation with tranexamic acid also delayed disease onset. The T-cell response to immunization was similar between genotypes, suggesting that the contribution of plasminogen was downstream of the T-cell response. Spinal cords from EAE-challenged Plg−mice demonstrated significantly decreased demyelination and microglial/macrophage accumulation compared with Plg+mice. Although fibrinogen-deficient mice or mice with combined deficiencies of plasminogen and fibrinogen had decreased EAE severity, they did not exhibit the delay in EAE disease onset, as seen in mice with plasminogen deficiency alone. Together, these data suggest that plasminogen and plasmin-mediated fibrinolysis is a key modifier of the onset of neuroinflammatory demyelination.SIGNIFICANCE STATEMENTMultiple sclerosis is a severe, chronic, demyelinating disease. Understanding the pathobiology related to the autoreactive T-cell and microglial/macrophage demyelinating response is critical to effectively target therapeutics. We describe for the first time that deficiency of plasminogen, the key fibrinolytic enzyme, delays disease onset and protects from the development of the paralysis associated with a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). Administration of a widely used, pharmacologic inhibitor of plasminogen activation, tranexamic acid, also delays the onset of neuroinflammation associated with EAE.
A hospice önkéntesség lélektani vonatkozásainak szakirodalmi áttekintése
Authors: Dorner László , Fürné Mosoni Anita , Hatvani Andrea 
Published: March 2017

Háttér és célkitűzések
Jelen tanulmány célja, hogy áttekintse és rendszerezze a hospice önkéntesség lélektani vonatkozásait vizsgáló kutatások elmúlt évtizedekben született eredményeit, különös tekintettel az önkéntes tevékenységeinek, személyiség- és motivációs hátterének kutatásaira.

Módszer
Tudományos adatbázisokban történő kulcsszavas keresés és a téma szempontjából releváns magyar (Kharón Thanatológiai Szemle) és angol nyelvű közlemények (n = 60) kiválasztása után azok szisztematikus szakirodalmi áttekintése különböző témák alapján (motivációk, személyiség, észlelt kihívások, stressztényezők).

Eredmények
A kutatások nagy része kiemeli, hogy míg a hospice szolgáltatások elkezdése, majd később folytatása is jelentős összefüggést mutat a magas szintű altruisztikus motivációkkal (pl. társadalmi felelősségvállalás, mások fájdalmának enyhítésére irányuló vágy, proszociális értékek kifejezése, morális felelősség), addig az egoisztikus motivációk (pl. önértékelés növelése, személyes növekedés, szociális kapcsolatok, karrier) főként az önkéntesség kezdeti szakaszában fontosak, és a hosszú távú önkéntessé válás során már kevésbé meghatározónak tekinthetők. Bár a személyes érintettség (pl. egy hozzátartozó halála vagy saját betegség) gyakori motívum az önkéntesség elkezdésének hátterében, a hosszú távú önkéntessé válásra az önkéntesként megélt tapasztalatok (a valahová tartozás érzése, jelentőségteljes munka végzése és a hospice team tagjaival való hatékony együttműködés) gyakorolják a legjelentősebb hatást. Az önkéntesek személyiségvonásait vizsgálva az életkori vagy nemi sztenderdekhez, illetve az önkéntes tevékenységeket nem végzőkhöz képest általában magasabb Extraverzió, Barátságosság és Nyitottság, valamint alacsonyabb Neuroticizmus pontszámokat találunk. Természetesen az további vizsgálat tárgyát képezheti, hogy ez az eredmény az önkéntesség hatására jött létre, vagy eleve azok jelentkeztek önkéntesnek, akik ezekkel a pontszámokkal voltak jellemezhetőek. Ugyancsak összekapcsolódik a hospice önkéntességgel a magasabb empátiás törődés, gondoskodásigény és szociális nézőpontváltásra való képesség is, amelyek nélkül a nehéz érzelmi helyzetekkel (kliensek elvesztése, nővérektől és hozzátartozóktól érkező elutasítás) való hatékony megküzdés elképzelhetetlennek tűnik.

Következtetések
A hospice önkéntesség egy magas frusztrációs toleranciát, folyamatos önismereti munkát és hatékony megküzdési módokat igénylő önkéntességtípus. Ennek lélektani szempontú vizsgálatakor egyaránt figyelembe kell vennünk az önkéntes személyre és az önkéntesség haszonélvezőjének pszichés jellemzőire gyakorolt hatást.
Safety and Tolerability of PD-1/PD-L1 Inhibitors Compared with Chemotherapy in Patients with Advanced Cancer: A Meta-Analysis
Authors: Nishijima Tomohiro F. , Shachar Shlomit S. , Nyrop Kirsten A. , Muss Hyman B. 
Published: March 2017

Abstract

Background
Compared with chemotherapy, significant improvement in survival outcomes with the programmed death receptor-1 (PD-1) inhibitors nivolumab and pembrolizumab and the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab has been shown in several types of advanced solid tumors. We conducted a systematic review and meta-analysis to compare safety and tolerability between PD-1/PD-L1 inhibitors and chemotherapy.

Methods
PubMed and American Society of Clinical Oncology (ASCO) databases were searched 1966 to September 2016. Eligible studies included randomized controlled trials (RCTs) comparing single-agent U.S. Food and Drug Administration–approved PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, or atezolizumab) with chemotherapy in cancer patients reporting any all-grade (1–4) or high-grade (3–4) adverse events (AEs), all- or high-grade treatment-related symptoms, hematologic toxicities and immune-related AEs, treatment discontinuation due to toxicities, or treatment-related deaths. The summary incidence, relative risk, and 95% confidence intervals were calculated.

Results
A total of 3,450 patients from 7 RCTs were included in the meta-analysis: 4 nivolumab, 2 pembrolizumab, and 1 atezolizumab trials. The underlying malignancies included were non-small cell lung cancer (4 trials) and melanoma (3 trials). Compared with chemotherapy, the PD-1/PD-L1 inhibitors had a significantly lower risk of all- and high-grade fatigue, sensory neuropathy, diarrhea and hematologic toxicities, all-grade anorexia, nausea, and constipation, any all- and high-grade AEs, and treatment discontinuation. There was an increased risk of all-grade rash, pruritus, colitis, aminotransferase elevations, hypothyroidism, and hyperthyroidism, and all- and high-grade pneumonitis with PD1/PD-L1 inhibitors.

Conclusion
PD-1/PD-L1 inhibitors are overall better tolerated than chemotherapy. Our results provide further evidence supporting the favorable risk/benefit ratio for PD-1/PD-L1 inhibitors.
Perception of Marathi consonant manner contrasts in children with and without hearing impairment
Authors: Nandurkar Aparna , Mukundan Geetha 
Published: March 2017

<p class="abstract"><strong>Background:</strong> Very few published studies have reported phoneme contrasts in children with and without hearing impairment in Indian languages. The present study is aimed at comparing perception of manner contrasts in 6 to 8 year old Marathi children with normal hearing and those with hearing impairment using hearing aids and cochlear implants<span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> Two hundred 6 to 8 year olds participated across three groups: 106 with normal hearing (NH), 47 with hearing aids (HA) and 47 with cochlear implants (CI). Perception of four consonant manner contrasts was assessed using a four-alternative, forced choice picture-pointing task using recorded minimal pairs with CVC or CVCV words: a) Stop vs. Fricative; b) Stop vs. Nasal; c) Stop vs. Affricate and d) Aspiration<span lang="EN-IN">. </span></p><p class="abstract"><strong>Results:</strong> All NH participants obtained ceiling scores for stop vs. fricative and stop vs. nasal contrasts. NH participants performed significantly better than participants with CI on all contrasts. Performance of HA participants was more variable and significantly poorer than the CI participants. Children implanted at or before 4 years of age and those using CI for more than 2.5 years performed consistently better on all contrasts as compared to those implanted after 4 years of age and using it for less than 2.5 years. Children fitted with HA at or after 2.5 years of age performed consistently better than those fitted before 2.5 years of age. Participants with average hearing aided thresholds 45 dB HL or lower (better) performed better than those with average aided thresholds above 45 dB HL<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> Normative data on perception of various manner contrasts in Marathi is generated. Phoneme perception skills of children with NH are significantly better than those of children with CI and HA<span lang="EN-IN">.</span></p>
Reconstructive techniques in head and neck malignancies
Authors: K. Shashhidhar , Doreyawar Venkatesh , Malick Nabeel , N. S. Sandhya , H. N. Preetham , Puthukulangara Shruthi , K. M. Vidyashree 
Published: March 2017

<p class="abstract"><strong>Background:</strong> Head and neck malignancies are of common occurrence in India requiring early diagnosis for effective reconstruction by various surgical techniques. The aim of the present study was to evaluate the pattern of involvement of head and neck malignancies and to evaluate various surgical resection and reconstruction techniques used in the management of head and neck malignancies<span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> This is a retrospective study carried out in the Department of ENT and Head &amp; Neck Surgery And Surgical Oncology, Karnataka Institute Of Medical Sciences, Hubballi, from July 2015 to December 2016. All patients who underwent surgery for head and neck malignancy were included in our study<span lang="EN-IN">. </span></p><p class="abstract"><strong>Results:</strong> Retrospective analysis of our study yielded 36 cases of which 29 patients were male and 7 were female. In our study commonest age group was 6<sup>th</sup> and 7<sup>th</sup> decade constituting 55.55%. The most common site involved was oral cavity constituting about 63.88%. The most common sub-site in oral cavity malignancy was found to be anterior 2/3<sup>rd</sup>of tongue (25%), followed by lip and buccal mucosa each of which constituted 13.88%<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> In our study oral cavity was the most common site to be involved in head and neck malignancies, of which anterior 2/3rd of tongue is the most common sub-site. Majority of the patients underwent tumour resection with flap reconstruction. Locoregional flaps form an efficient alternative in cases where primary closure is not possible without compromising the aesthetic outcomes<span lang="EN-IN">.</span></p>
A clinicopathological study of masses of nasal cavity paranasal sinuses and nasopharynx
Authors: Sharma Rajat , Sahni Dimple , Uppal Kuljeet , Gupta Rajeev , Singla Gifty 
Published: March 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">A variety of inflammatory, non neoplastic and neoplastic masses involving nasal cavity, paranasal sinuses and nasopharynx are commonly encountered in ENT clinics. The objective was to study the demographic profile, clinical presentation, radiological findings and its correlation with the histopathological findings of masses of nasal cavity, paranasal sinuses and nasopharynx. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The study was conducted on patients having sinonasal and nasopharyngeal masses admitted in dept of ENT, GMC, Patiala from August 2014 to July 2016. The study was designed to evaluate demographic distribution, clinicopathological features, radiological findings of sinonasal and nasopharyngeal masses and to evaluate the correlation of clinical and radiological findings with histopathological diagnosis. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Analysis of 50 cases of masses in nasal cavity, paranasal sinuses and nasopharynx was done. Male to female ratio was 1.38:1. The commonest site was nasal cavity followed by paranasal sinuses. Nasal polyp was the most common non-neoplastic lesion. Among the neoplastic lesions studied, inverted papilloma was the most common benign lesion and squamous cell carcinoma was the most common malignant lesion observed. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">For proper evaluation of sinonasal and nasopharyngeal masses, clinical, radiological and histopathological evaluation should be done in all patients. Although radiology provides a road map to endoscopic surgeons for any existing or impending complications but histopathology always gives a confirmatory diagnosis.</span></p>
El multiculturalismo como una opción para generar ciudadanía: un diálogo entre Claude Geffré y Adela Cortina
Authors: Hernández-Acevedo Álvaro 
Published: March 2017

Las leyes del mercado le plantean a la sociedad actual las nuevas reglas de vida y de las relaciones humanas, por lo tanto, busca por necesidad, nuevas opciones de convivencia y hasta sobrevivencia, frente a los problemas globales como la pobreza, la desigualdad económica, el terrorismo global, y el sinsentido de una juventud ahistórica. (Bauman, 2009, p. 266). Ante esta situación, la filosofía y la teología deben plantear y generar nuevos espacios de diálogo, análisis y crítica para resignificar el concepto de ciudadanía, relacionado con la dignidad humana y los derechos humanos. En primer lugar, se presentan las condiciones de posibilidad para el multiculturalismo ante la filosofía y la teología, posteriormente una lectura dialógica entre los autores Claude Geffré y Adela Cortina, y, por último, la necesidad de buscar criterios y principios al momento de reconocer la importancia de la búsqueda de la dignidad de la vida humana en un mundo dehumanos.
DAMPAK KAWASAN INDUSTRI DI DESA BUTUH TERHADAP PEREKONOMIAN DAN KEINGINAN BERWIRAUSAHA DI KECAMATAN MOJOSONGO, BOYOLALI
Authors: Istiqomah Nurul , Prasetyani Dwi 
Published: March 2017

<p>This background of this research is the establishment of several factories in Butuh Village, Mojosongo Sub-District, Boyolali Regency, which forms an industrial area. In the past, the residents of Butuh Village worked by cultivating land and breeding livestock because the soil in this area is barren and water sources are difficult to find. Because of the establishment of industrial area, the economic activity of this area increases significantly.</p><p>This research uses descriptive-quantitative research method. Qualitative analysis is used to discover the increase of economic activity and the level of health and education of the surrounding community. Whereas quantitative analysis was conducted by using Paired Samples T test. This test is used to discover the presence of average difference between two paired (corresponding) sample groups. In this case, it is about community’s income and expenditure in the surroundings of industrial area. Whereas regression analysis, specifically Ordinary Least Square(OLS) Logit, is used to discover community’s entrepreneurship desire after the existence of industrial area.</p><p>The impact of industrial area in Butuh Village, Mojosongo Sub-district can reduce unemployment rate. However,most people in Butuh Village prefer becoming entrepreneurs around the industrial area to factory workers. Additional income earned shifts the way of thinking of people around industrial area in the field of education and health. In addition, there were differences of income and expenditure between the times before and after the existence of industrial area in Butuh Village. The last, education, income and expenditure influence the entrepreneurial decision.</p><p> </p><p><strong>Key words: Industrial Area, Income, Expenditure, Paired Samples T-test, Logit.</strong></p>
ECONOMIC GROWTH MODEL LOCATION QUOTIENT (LQ) IN EAST JAVA PROVINCE
Authors: Priana Wiwin 
Published: March 2017

<p>SuatuSektor ekonomi suatu daerah merupakan motor dari pembangunan nasional, karena tanpa dukungan dari daerah – daerah yang ada maka pembangunan nasional akan sulit untuk tercapai. Sama halnya dengan mottoyang diusung oleh pembangunan nasional, pembangunan daerah pun juga dari, oleh, dan untuk daerah tersebut. Jadi pembangunan daerah adalah buah dari inovasi dan kombinasi daerah itu sendiri untuk pencapaian kemajuan dan kesejahteraan bersama.</p><p>Salah satu indikator tercapainya suatu pembangunan daerah adalah pertumbuhan ekonomi yang terus meningkat kearah signifikan. Artinya pertumbuhan ekonomi dapat terus meningkat seiring dengan perbaikan - perbaikan yang ada pada sektor pendorong ekonomi. Keberhasilan pembangunan daerah juga dinilai dari kemampuan daerah tersebut untuk mencukupi kebutuhan masyarakatnya dan mengembangkan segala potensi yang ada.</p><p>. </p><p>Dalam penelitian merupakan lanjutan dari penelitian pertama tentang pertumbuhan sector dari Shift Sahare di Kabupaten dan kota Di jawa Timur maka dapat diketahui hasil Shioft Share PR (Potensi Regional ) dari kabupaten dan kota mempunyai keunggulan sector yang mendorong pertumbuhan PDRB Jawa Timur PR&lt;dQ) artinya sector tersebut dikabupaten sersebut dapat mendorong pertumbuhan Ekonomi Jawa Timur</p><p>Dari PR (Potesi Regional ini, maka dalam penelitian ini akan dilihat Location Qoutien , untuk PDRB Bila LQ &gt; 1 Maka Sektor tersebut sector Basis dan Bila LQ &lt; sector tersebut sektor non basis,</p><p><strong> </strong></p><p><strong>Kata kunci : Sektor Basis,Sektor Non Basis</strong></p>
SHG Federations as Livelihood Support Organizations
Authors: Navin T. , Rao N. Srinivasa , Singh Shashank , Gautam Rajendra Singh 
Published: March 2017

<em>The last two decades has witnessed a phenomenal growth in the number of Self Help groups (SHGs) and SHG federations in India. There were an estimated 1, 78,664 SHG federations in India during 2013-14. SHG federations emerged as important institutions to take over the functions formerly provided by SHG promoting organizations. Placed in a situation where small size of SHGs and their limited financial and human resourcesdid not allow it to deal with larger financial and non-financial, livelihood issues affecting their women members, SHG federations were to address this gap. It was to go beyond being mere financial intermediaries to also become livelihood promotion organizations. The paper argues that while SHG Federations have emerged as financial intermediaries, its role as livelihood support organizations is still a question mark. The study looks at the role of SHG federations as livelihood support organizations.</em>
Biosorption of Copper (II) from Aqueous Solutions by Sclerotiogenic Aspergillus oryzae G15
Authors: Long Dan‐Dan , Wang Qi , Han Jian‐Rong 
Published: March 2017

ABSTRACT: This study aimed at investigating the biosorption of copper(II) from aqueous solutions by sclerotiogenic Aspergillus oryzae G15. Potentiometric titration analysis results indicated that carboxyl group was mainly responsible for Cu(II) adsorption. Sclerotia were a better biosorbent than mycelia, which could be ascribed to the higher amount of carboxyl sites exposed after differentiation. Langmuir isotherm model fitted well the absorption process of mycelia and sclerotia with the maximum theoretical sorption capacities of 35.34 and 73.53 mg/g, respectively. Scanning electron microscopy coupled with energy dispersive X‐ray analysis confirmed that there was surface biosorption of Cu(II) on the adsorbents. Based on the fourier transform infrared spectroscopy analyses results, it could be proposed that the increased sorption capacity of sclerotia was due to increased functional groups related to the biosorption process. Cu(II)‐loaded biosorbents could be regenerated and reused, which indicated that A. oryzae G15 could be considered as an alternative for removing Cu(II) from wastewater.