bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extreme tropical cyclone activities in the southern Pacific Ocean
Authors: Hoarau Karl , Chalonge Ludovic , Pirard Florence , Peyrusaubes Daniel 
Published: September 2017

ABSTRACTThis research concerning the South Pacific Ocean shows the 10‐year and interannual variability of extreme cyclones (categories 4 and 5). The intensity of these cyclones has been reanalysed on the basis of GMS, GOES and NOAA satellite images with the Dvorak technique. In the period 1980–2016, 63 cyclones reached categories 4 and 5. During the decade 1980–1989, the intensity of cyclones of at least 115 knots over 1 min (100 knots over 10 min used by the meteorological centres in the South Pacific) was underestimated: we found 19 such cyclones, as opposed to 11 in IBTrACS, and 6 in the SPEArTC and in the Joint Typhoon Warning Center (JTWC) databases. Between 1980 and 2016, the number of extreme cyclones did not show any tendency to increase. The 1983 season was the most active, with six cyclones of categories 4 and 5 that do not figure in the JTWC database for the South Pacific. Only one intense cyclone has been reported in the SPEArTC and five cyclones in IBTrACS in 1983. El Niño episodes concurred with a much higher number of cyclones of at least 115 knots than La Niña episodes. More than half of the category 5 (at least 140 knots) cyclones were observed during El Niño years. The South Pacific Ocean is the theatre of very intense cyclones, comparable to those in the western or eastern North Pacific. Thus, by reanalysing satellite images, an intensity of 170 knots was attributed to cyclone Hina (March 1985), which was probably one of the strongest in the southern hemisphere since 1980.
High‐performance liquid chromatography thermodynamic study of new potential antiepileptic compounds on a cholesterol column using isocratic elution with methanol/water and acetonitrile/water eluent systems
Authors: Flieger Jolanta , Trębacz Hanna , Pizoń Magdalena , Kowalska Anna , Szczęsna Agnieszka , Plech Tomasz 
Published: September 2017

AbstractBasic thermodynamic functions responsible for retention of new 1,2,4‐triazole derivatives exhibiting varied antiepileptic activity on cholesterol‐based stationary phase were determined. Evaluation of the Gibbs energy change, the change in enthalpy and the change in entropy was based on the van't Hoff relationship representing lnk versus 1/T. A detailed discussion of the van't Hoff equation, exploring the influence of the phase ratio on deviations from linearity in a van't Hoff plot is presented. We show chromatographic evidence to the question of how a varied mobile phase composition may cause different thermodynamic phase ratios. The analysis of data from a differential scanning calorimetry excluded any phase transitions of either the individual solutes or cholesterol stationary phase suspended in the mobile phase components within the studied temperature range.
Development of multiple monolithic fiber solid‐phase microextraction and liquid chromatography–tandem mass spectrometry method for the sensitive monitoring of aminoglycosides in honey and milk samples
Authors: Chen Lei , Mei Meng , Huang Xiaojia 
Published: September 2017

AbstractA simple and sensitive method for the simultaneous extraction and determination of six aminoglycosides in honey and milk samples was developed using multiple monolithic fiber solid‐phase microextraction and liquid chromatography with tandem mass spectrometry. The multiple monolithic fibers based on poly(methacrylic acid‐co‐ethylenedimethacrylate) monolith as the extraction medium was used to concentrate target analytes. Because there were abundant carboxyl groups in the monolith, the monolithic fibers could extract aminoglycosides effectively through cation‐exchange and hydrophobic interactions. To obtain optimum extraction performance, several extraction parameters including desorption solvent, adsorption and desorption time, pH value and ionic strength in sample matrix, were investigated in detail. Under the optimized extraction conditions, the limits of detection of the proposed method were 0.10–0.30 and 0.23–0.59 μg/kg for honey and milk samples, respectively. Satisfactory linearity was achieved for analytes with the coefficients of determination above 0.99. At the same time, the developed method showed acceptable method repeatability and reproducibility. Finally, the proposed method was successfully applied to the determination of aminoglycosides in real honey and milk samples. Recoveries obtained for the determination of six target analytes in spiking samples ranged from 67.9 to 110%, and the relative standard deviations were in the range of 1.2–11%.
Prophylactic immunization with human papillomavirus vaccines induces oral immunity in mice
Authors: Ahn Julie , Peng Shiwen , Hung Chien‐Fu , Roden Richard B. S. , Best Simon R. 
Published: September 2017

ObjectiveAlthough it has been shown that prophylactic vaccination can induce genital immunity, there is inadequate information on human papillomavirus (HPV) vaccine‐induced oral immunity, which is of particular interest due to HPV‐associated oropharyngeal malignancies and recurrent respiratory papillomatosis. Therefore, we assessed the efficacy of various HPV vaccines against oral HPV pseudovirus (PsV) infection in mice.Study DesignPreclinical scientific investigation.MethodsC57BL/6 mice were vaccinated three times at 2‐week intervals with either Gardasil (Merck, Kenilworth, NJ) (50 µL intramuscular injection) or a candidate pan‐HPV L2 vaccine with alum adjuvant (25 µg subcutaneous injection). Additional mice were immunized with passive transfer of either Gardasil (Merck) human antisera or nonimmunized sera (100 µL intraperitoneal injection). All vaccinated and naïve control mice were then challenged with HPV16 E6E7 luciferase PsV in the oral mucosa. Visualization of HPV PsV infection was monitored through in vivo luciferase imaging.ResultsOral luciferase‐expressing HPV16 PsV infection was not detected in Gardasil (Merck), L2 vaccine, and Gardasil (Merck) antisera‐immunized mice, whereas robust luciferase expression was observed in all control mice. An in vitro neutralization assay from sera of Gardasil‐vaccinated (Merck) mice confirmed that vaccine efficacy was due to neutralizing antibodies.ConclusionOral HPV16 PsV infection in mice was completely prevented with all methods of prophylactic HPV immunization. These findings provide preliminary evidence that human vaccines induce protection against oral HPV infection, which has significant public health implications for HPV‐associated oropharyngeal malignancies.Level of EvidenceNA. Laryngoscope, 128:E16–E20, 2018
Competency‐based assessment in surgeon‐performed head and neck ultrasonography: A validity study
Authors: Todsen Tobias , Melchiors Jacob , Charabi Birgitte , Henriksen Birthe , Ringsted Charlotte , Konge Lars , von Buchwald Christian 
Published: September 2017

ObjectiveHead and neck ultrasonography (HNUS) increasingly is used as a point‐of‐care diagnostic tool by otolaryngologists. However, ultrasonography (US) is a very operator‐dependent image modality. Hence, this study aimed to explore the diagnostic accuracy of surgeon‐performed HNUS and to establish validity evidence for an objective structured assessment of ultrasound skills (OSAUS) used for competency‐based assessment.Study DesignA prospective experimental study.MethodsSix otolaryngologists and 11 US novices were included in a standardized test setup for which they had to perform focused HNUS of eight patients suspected for different head and neck lesions. Their diagnostic accuracy was calculated based on the US reports, and two blinded raters assessed the video‐recorded US performance using the OSAUS scale.ResultsThe otolaryngologists obtained a high diagnostic accuracy on 88% (range 63%–100%) compared to the US novices on 38% (range 0–63%); P < 0.001. The OSAUS score demonstrated good inter‐case reliability (0.85) and inter‐rater reliability (0.76), and significant discrimination between otolaryngologist and US novices; P < 0.001. A strong correlation between the OSAUS score and the diagnostic accuracy was found (Spearman's ρ, 0.85; P < P 0.001), and a pass/fail score was established at 2.8.ConclusionStrong validity evidence supported the use of the OSAUS scale to assess HNUS competence with good reliability, significant discrimination between US competence levels, and a strong correlation of assessment score to diagnostic accuracy. An OSAUS pass/fail score was established and could be used for competence‐based assessment in surgeon‐performed HNUS.Level of EvidenceNA. Laryngoscope, 128:1346–1352, 2018
Clinical characteristics of laryngeal versus nonlaryngeal amyloidosis
Authors: Rudy Shannon F. , Jeffery Caroline C. , Damrose Edward J. 
Published: September 2017

Objectives/HypothesisAmyloidosis represents a heterogeneous group of disorders marked by abnormal protein formation and deposition. Laryngeal amyloidosis is rare and classically thought to remain isolated with little risk of systemic involvement or associated malignancy. This study sought to further characterize differences in clinical characteristics between patients with laryngeal and nonlaryngeal amyloidosis.Study DesignRetrospective case‐control study.MethodsThe Stanford Translational Research Integrated Database Environment was searched to identify patients with biopsy‐confirmed laryngeal amyloidosis and patients with amyloidosis without laryngeal involvement on endoscopy. Mann‐Whitney U and χ2 tests were used for statistical analysis.ResultsOf 865 patients treated for amyloidosis between 1996 and 2016, 22 (2.5%) patients with biopsy‐proven laryngeal amyloidosis were identified. An additional 22 patients with amyloidosis of a different organ and negative laryngoscopy—and therefore without laryngeal amyloidosis—were identified as controls. Compared to these controls with nonlaryngeal amyloidosis, patients with laryngeal amyloidosis were younger (mean age 52.8 years vs. 68.4 years, P < .0006), and 18% had additional organ involvement. Immunoglobulin light‐chain amyloidosis was the most common subtype in both groups of patients. Eighty‐six percent of patients with laryngeal amyloidosis required surgical excision, and of these patients, over 30% required multiple excisions.ConclusionsThere is a significant rate (18%) of multiorgan involvement in patients with laryngeal amyloidosis, which contradicts conventional concepts that this is an isolated disorder. This finding could have a significant impact on the evaluation and management of patients with laryngeal amyloidosis.Level of Evidence3b. Laryngoscope, 128:670–674, 2018
Self‐Assembly of Thermoresponsive Recombinant Silk‐Elastinlike Nanogels
Authors: Isaacson Kyle J. , Jensen Mark Martin , Watanabe Alexandre H. , Green Bryant E. , Correa Marcelo A. , Cappello Joseph , Ghandehari Hamidreza 
Published: September 2017

AbstractRecombinant silk‐elastinlike protein polymers (SELPs) combine the biocompatibility and thermoresponsiveness of human tropoelastin with the strength of silk. Direct control over structure of these monodisperse polymers allows for precise correlation of structure with function. This work describes the fabrication of the first SELP nanogels and evaluation of their physicochemical properties and thermoresponsiveness. Self‐assembly of dilute concentrations of SELPs results in nanogels with enhanced stability over micelles due to physically crosslinked beta‐sheet silk segments. The nanogels respond to thermal stimuli via size changes and aggregation. Modifying the ratio and sequence of silk to elastin in the polymer backbone results in alterations in critical gel formation concentration, stability, aggregation, size contraction temperature, and thermal reversibility. The nanogels sequester hydrophobic compounds and show promise in delivery of bioactive agents.
Framework for assessment of climate change impact on offshore wind energy
Authors: Kulkarni Sumeet , Deo M. C. , Ghosh Subimal 
Published: September 2017

ABSTRACTA probabilistic framework for evaluating changes in offshore wind potential under a changing climate is presented considering three general circulation models (GCMs), two representative concentration pathways and two statistical downscaling techniques. The analysis was done with respect to three specific locations along the Indian coastline, identified earlier for future offshore energy extraction. The uncertainty among the GCMs was addressed and the choice of an appropriate GCM was made by combining analysis of GCM uncertainty and model reliability. The regional scale wind was derived from the selected GCM using one hard computing method, namely bilinear interpolation and quantile mapping, and one soft method, an artificial neural network. The efficiency of these methods was assessed using certain performance criteria for the historical period and a convergence criterion over the future period. To evaluate wind potential, the GCM output was downscaled from daily to hourly, taking into account the removal of gusts because of long interval averaging. The wind potential for past (1979–2005) and future (2006–2032) time slices was determined using both hard and soft methods as well as two representative concentration pathways. The resulting four outcomes at annual and seasonal scale were compared with the extrapolated trend of past wind potential derived from both GCM and reanalysis data. Finally, the most efficient strategy was evaluated and the actual extractable power was estimated considering a standard power curve. It is concluded that at all the three locations the annual average wind potential will substantially increase, benefitting the offshore industry.
Pulmonary embolism in pregnant patients: Assessing organ dose to pregnant phantom and its fetus during lung imaging
Authors: Rafat Motavalli Laleh , Hoseinian Azghadi Elie , Miri Hakimabad Hashem , Akhlaghi Parisa 
Published: September 2017

PurposeThe purpose of this study was to provide updated radiation dose from diagnostic exams performed for pregnant patients suspected of pulmonary embolism (PE) using the recently developed BREP phantoms of pregnant woman and the fetus. Also to challenge the validity of current recommendations suggest that ventilation/perfusion (V/Q) single photon emission computed tomography (SPECT) vs. computed tomography pulmonary angiography (CTPA) should be considered for diagnosis of PE in radiosensitive groups such as pregnant women.MethodsThe Monte Carlo calculations involving detailed geometrical simulation of pregnant women and the fetus were performed.ResultsThe results showed that when radiation dose to the fetus is of concern, CTPA is more appropriate at early stages causes 50%–97% lower fetal doses for the first two trimesters of pregnancy. While for gestational periods more than 6 months, V/Q SPECT leads to a 15% lower fetal dose and thus, is less hazardous. The fetal dose from CTPA increases with gestational age, while that from V/Q SPECT decreases. Furthermore, the maximum amount of fetal dose is received by fetal skeleton (i.e., on average about 1.8 and 3.9 times larger dose from SPECT and CT, respectively).ConclusionsV/Q SPECT should not always be preferred for pregnant patients suspected of PE. This finding is in contrast with the guidance to choose the preferred modality based on the maternal effective dose. The reason of this issue was discussed in this paper based on chord length distributions (CLDs). The importance of considering fetal organs separately in MC calculations was also highlighted.
Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Authors: Rodrigues‐Tartari Raíssa , Swardfager Walter , Salum Giovanni A. , Rohde Luís A. , Cogo‐Moreira Hugo 
Published: September 2017

AbstractTo test how reliable the tool recommend by Cochrane Collaboration for assessing risk of bias systematic reviews of randomized clinical trials is in the context of methylphenidate for children and adolescents with attention deficit hyperactivity disorder. Confirmatory factor analysis was used to evaluate a unidimensional model for the 7 indicators, applied to 184 Randomized Clinical Trial (RCTs) within a 2015 Cochrane systematic review titled “Methylphenidate for children and adolescents with attention deficit hyperactivity disorder.” A unidimensional model resulted in excellent adequacy indices, but only 2 indicators had very high factor loadings and low measurement errors. In terms of content, the 7 indicators showed poor reliability (ω = 0.642); however, the set of indicators was precise in evaluating studies with a high amount of bias risk. The Cochrane model of risk of bias as it is, exhibited good fit indices but the majority of the items were not reliable to adequately capture risk of bias in the context of clinical trials of methylphenidate for ADHD.
Long‐term pulmonary disease among Swiss childhood cancer survivors
Authors: Kasteler Rahel , Weiss Annette , Schindler Matthias , Sommer Grit , Latzin Philipp , von der Weid Nicolas X. , Ammann Roland A. , Kuehni Claudia E. ,   Swiss Pediatric Oncology Group (SPOG)
Published: September 2017

AbstractBackgroundPulmonary diseases are potentially severe late complications of childhood cancer treatment that increase mortality risk among survivors. This nationwide study assesses the prevalence and incidence of pulmonary diseases in long‐term childhood cancer survivors (CCS) and their siblings, and quantifies treatment‐related risks.MethodsAs part of the Swiss Childhood Cancer Survivor Study, we studied CCS who were diagnosed between 1976 and 2005 and alive at least 5 years after diagnosis. We compared prevalence of self‐reported pulmonary diseases (pneumonia, chest wall abnormalities, lung fibrosis, emphysema) between CCS and their siblings, calculated cumulative incidence of pulmonary diseases using the Kaplan–Meier method, and determined risk factors using multivariable logistic regression.ResultsCCS reported more pneumonias (10% vs. 7%, P = 0.020) and chest wall abnormalities (2% vs. 0.4%, P = 0.003) than siblings. Treatment with busulfan was associated with prevalence of pneumonia (odds ratio [OR] 4.0, 95% confidence interval [CI] 1.1–14.9), and thoracic surgery was associated with chest wall abnormalities and lung fibrosis (OR 4.1, 95% CI 1.6–10.7 and OR 6.3, 95% CI 1.7–26.6). Cumulative incidence of any pulmonary disease after 35 years of follow‐up was 21%. For pneumonia, the highest cumulative incidence was seen in CCS treated with both pulmotoxic chemotherapy and radiotherapy to the thorax (23%).ConclusionThis nationwide study in CCS found an increased risk for pulmonary diseases, especially pneumonia, while still young, which indicates that CCS need long‐term pulmonary follow‐up.
Intravenous‐only or Intravenous Transitioned to Oral Antimicrobials for Enterobacteriaceae‐Associated Bacteremic Urinary Tract Infection
Authors: Rieger Krista L. , Bosso John A. , MacVane Shawn H. , Temple Zachary , Wahlquist Amy , Bohm Nicole 
Published: September 2017

ObjectivesTo characterize antibiotic regimens utilized for bacteremic Enterobacteriaceae urinary tract infections and assess treatment failure associated with intravenous‐only compared to intravenous transitioned to oral antibiotic treatment.DesignRetrospective cohort.SettingsTertiary care academic medical center.Patients241 adult patients hospitalized between July 1, 2010, and June 30, 2015, with positive blood and urine cultures with the same Enterobacteriaceae pathogen.Main ResultsHospital days on antibiotics as well as length of stay were less in the group treated with any oral antibiotics (intravenous/oral, median 5 [IQR 3–7] days vs intravenous‐only antibiotics 6 [4–10] days, p<0.001; length of stay for intravenous/oral 4.6 [3.1–7.8] days vs intravenous‐only 7.1 [4.0–17.5] days, p<0.001). No statistically significant difference was found in the composite outcome of treatment failure in patients who received intravenous‐only antibiotics versus intravenous/oral antibiotics for the treatment of bacteremic urinary tract infections (intravenous‐only 3.8% [95% CI: 1.0–9.4%] failure; intravenous/oral 8.2% [95% CI: 4.1–14.1%] failure; p=0.19).ConclusionsIntravenous transitioned to oral treatment (intravenous/oral) was associated with a shorter length of stay and fewer hospital antibiotic days compared with intravenous‐only therapy. Transitioning from intravenous to oral antibiotic therapy is a viable treatment option to consider for patients with bacteremic Enterobacteriaceae urinary tract infection.
Proteogenomic Insights into the Intestinal Parasite Blastocystis sp. Subtype 4 Isolate WR1
Authors: Armengaud Jean , Pible Olivier , Gaillard Jean‐Charles , Cian Amandine , Gantois Nausicaa , Tan Kevin S. W. , Chabé Magali , Viscogliosi Eric 
Published: September 2017

AbstractBlastocystis sp. is known for years as a highly prevalent anaerobic eukaryotic parasite of humans and animals. Several monophyletic clades have been delineated based on molecular data, and the occurrence of each subtype in humans and/or animal hosts has been documented. The genome of several representatives has been sequenced revealing specific traits such as an intriguing 3'‐end processing of primary transcripts. Here, a first high‐throughput proteomics dataset acquired on this difficult‐to‐cultivate parasite is presented for the zoonotic subtype T4 isolate WR1. Amongst the 2766 detected proteins, we highlighted the role of a small ADP ribosylation factor GTP‐binding protein involved in intracellular traffic as major regulator of vesicle biogenesis and a voltage‐dependent anion‐selective channel protein because both were unexpectedly highly abundant. We show how these data may be used for gaining proteogenomics insights into Blastocystis sp. specific molecular mechanisms. We evidenced for the first time by proteogenomics a functional termination codon derived from transcript polyadenylation for seven different key cellular components.
Low cost bifunctional initiators for bidirectional living cationic polymerization of olefins. I. isobutylene
Authors: Nugay Turgut , Keszler Balazs L. , Deodhar Tejal , Nugay Nihan , Kennedy Joseph P. 
Published: September 2017

ABSTRACTWe describe the discovery of novel low cost bifunctional initiators 2,4,7,9‐tetramethyl‐tricyclo[6.2.0.036]deca‐1(8),2,6‐triene‐4,9‐diol (bBCB‐diOH) and 4,9‐dichloro,2,4,7,9‐tetramethyl‐tricyclo[6.2.0.036]deca‐1(8),2,6‐triene (bBCB‐diCl), for living cationic bidirectional polymerization of olefins, for example, isobutylene. bBCB‐diOH was quantitatively synthesized in one step by UV radiation of commercially available diacetyl durene (DAD) and bBCB‐diCl by hydrochlorination of bBCB‐diOH. These molecules, in conjunction with TiCl4 coinitiator, initiate the living polymerization of isobutylene. Livingness was demonstrated by linear conversion versus molecular weight (MW) plots and narrow MW distributions. Polymerizations are slower than those initiated by the universally used “hindered” bifunctional initiator 5‐tert‐butyl‐1,3‐bis(1‐chloro‐1‐methyl)benzene and are suitable for rate studies. Herein, we report the synthesis, by the use of bBCB‐diCl, of relatively low MW (Mn < 3000 g mol−1) allyl‐telechelic polyisobutylene (PIB) used for the synthesis of PIB‐based polyurethanes and that of relatively high MW (Mn > 30,000) living PIB telechelics for the synthesis of thermoplastic elastomers. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3716–3724