bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteogenic Differentiation of Human Mesenchymal Stromal Cells on Surface-Modified Titanium Alloys for Orthopedic and Dental Implants
Authors: Giannoni Paolo , Muraglia Anita , Giordano Carmen , Narcisi Roberto , Cancedda Ranieri , Quarto Rodolfo , Chiesa Roberto 
Published: January 2018

Purpose Surface properties of titanium alloys, used for orthopedic and dental applications, are known to affect implant interactions with host tissues. Osteointegration, bone growth and remodeling in the area surrounding the implants can be implemented by specific biomimetic treatments; these allow the preparation of micro/nanostructured titanium surfaces with a thickened oxide layer, doped with calcium and phosphorus ions. We have challenged these experimental titanium alloys with primary human bone marrow stromal cells to compare the osteogenic differentiation outcomes of the cells once they are seeded onto the modified surfaces, thus simulating a prosthetic device-biological interface of clinical relevance. Methods A specific anodic spark discharge was the biomimetic treatment of choice, providing experimental titanium disks treated with different alkali etching approaches. The disks, checked by electron microscopy and spectroscopy, were subsequently used as substrates for the proliferation and osteogenic differentiation of human cells. Expression of markers of the osteogenic lineage was assessed by means of qualitative and quantitative PCR, by cytochemistry, immunohistochemistry Western blot and matrix metalloprotease activity analyses. Results Metal surfaces were initially less permissive for cell growth. Untreated control substrates were less efficient in sustaining mineralized matrix deposition upon osteogenic induction of the cells. Interestingly, bone sialo protein and matrix metalloprotease 2 levels were enhanced on experimental metals compared to control surfaces, particularly for titanium oxide coatings etched with KOH. Discussion As a whole, the KOH-modification of titanium surfaces seems to allow the best osteogenic differentiation of human mesenchymal stromal cells, representing a possible plus for future clinical prosthetic applications.
“I’m Doing the Best That I Can for Her”: Infant-Feeding Decisions of Mothers Receiving Medication-Assisted Treatment for an Opioid Use Disorder
Authors: McGlothen Kelly S. , Cleveland Lisa M. , Gill Sara L. 
Published: January 2018

Background: Several professional health organizations have made statements endorsing the safety of breastfeeding for women taking medication-assisted treatment for an opioid use disorder. Yet, breastfeeding initiation rates for this population are approximately 50% lower than the general United States’ population. Furthermore, little is known about what influences the infant-feeding decisions of these women. Research aim: This study aimed to describe what influences the infant-feeding decisions of women taking medication-assisted treatment for an opioid use disorder. Methods: Qualitative description was used. We conducted semistructured, individual interviews with mothers ( N = 8) who were receiving medication-assisted treatment during the postpartum period. We analyzed our data using thematic analysis. Results: We identified two themes: (a) what I heard about breastfeeding, and (b) doing what I feel is best for my baby. What I heard about breastfeeding reflects the information and misinformation that women received about breastfeeding. Doing what I feel is best for my baby describes the inner conflict that the women experienced. Most of the women in this study desired to breastfeed; however, all women reported that the social stigma surrounding methadone use strongly influenced their infant-feeding decision. Conclusion: This study sheds new light on what influences the infant-feeding decisions of women taking medication-assisted treatment and represents an initial step toward the development of targeted interventions to improve breastfeeding rates for this unique population.
Ischemic and bleeding outcomes after coronary artery bypass grafting among patients initially treated with a P2Y12 receptor antagonist for acute coronary syndromes: Insights on timing of discontinuation of ticagrelor and clopidogrel prior to surgery
Authors: Russo Juan J , James Tyler E , Ruel Marc , Dupuis Jean-Yves , Singh Kuljit , Goubran Daniel , Malhotra Nikita , Rubens Fraser , Chong Aun-Yeong , Hibbert Benjamin , Boland Paul , Tran Diem TT , Tanguay Jean-Francois , Lordkipanidzé Marie , Perrault Louis , Wells George A , Bourke Michael , Chan Vincent , So Derek YF 
Published: January 2018

Background: Clinical outcomes in acute coronary syndrome patients treated with P2Y12 inhibitors who require urgent coronary artery bypass grafting (CABG) have not been well studied. Methods: We examined clinical outcomes in acute coronary syndrome patients in relation to the timing of CABG following P2Y12 inhibitor discontinuation (<72 h, 72 h to five days, >5 days). The primary ischemic outcome was a composite of death, reinfarction, need for revascularization, or stroke. The primary safety outcome was bleeding of at least moderate severity as defined by a Universal Definition of Perioperative Bleeding class ≥2. Results: Among 508 patients (95 ticagrelor, 413 clopidogrel), the timing of CABG following P2Y12 inhibitor discontinuation was <72 h in 32.1%, 72 h to five days in 23.2% and >5 days in 44.7%. Compared with CABG within 72 h, CABG 72 h to five days (adjusted odds ratio (OR) 0.35; 95% confidence interval (CI) 0.14–0.85; p=0.02) but not >5 days (adjusted OR 0.62; 95% CI 0.33–1.16; p=0.14) after P2Y12 inhibitor discontinuation was associated with lower odds of the primary ischemic outcome. Compared with CABG within 72 h, CABG 72 h to five days (adjusted OR 0.38; 95% CI 0.22–0.66; p=0.001) and >5 days (adjusted OR 0.33; 95% CI 0.20–0.53; p<0.001) after P2Y12 inhibitor discontinuation were associated with lower rates of Universal Definition of Perioperative Bleeding class ≥2 bleeding. Conclusions: CABG within 72 h after P2Y12 inhibitor discontinuation is associated with excess ischemia and bleeding. The rates of ischemic and bleeding events were comparable in patients undergoing CABG 72 h to five days compared with >5 days after P2Y12 inhibitor discontinuation.
Unlocking an acute psychiatric ward: The impact on unauthorised absences, assaults and seclusions
Authors: Beaglehole Ben , Beveridge John , Campbell-Trotter Warren , Frampton Chris 
Published: January 2018

Aims and methodThe acute psychiatric inpatient service in Christchurch, New Zealand, recently changed from two locked and two unlocked wards to four open wards. This provided the opportunity to evaluate whether shifting to an unlocked environment was associated with higher rates of adverse events, including unauthorised absences, violent incidents and seclusion. We compared long-term adverse event data before and after ward configuration change.ResultsRates of unauthorised absences increased by 58% after the change in ward configuration (P = 0.005), but seclusion hours dropped by 53% (P = 0.001). A small increase in violent incidents was recorded but this was not statistically significant.Clinical implicationsAlthough unauthorised absences increased, the absence of statistically significant changes for violent incidents and a reduction in seclusion hours suggest that the change to a less restrictive environment may have some positive effects.
Understanding variation in metabolic rate
Authors: Pettersen Amanda K. , Marshall Dustin J. , White Craig R. 
Published: January 2018

ABSTRACTMetabolic rate reflects an organism's capacity for growth, maintenance and reproduction, and is likely to be a target of selection. Physiologists have long sought to understand the causes and consequences of within-individual to among-species variation in metabolic rates – how metabolic rates relate to performance and how they should evolve. Traditionally, this has been viewed from a mechanistic perspective, relying primarily on hypothesis-driven approaches. A more agnostic, but ultimately more powerful tool for understanding the dynamics of phenotypic variation is through use of the breeder's equation, because variation in metabolic rate is likely to be a consequence of underlying microevolutionary processes. Here we show that metabolic rates are often significantly heritable, and are therefore free to evolve under selection. We note, however, that ‘metabolic rate’ is not a single trait: in addition to the obvious differences between metabolic levels (e.g. basal, resting, free-living, maximal), metabolic rate changes through ontogeny and in response to a range of extrinsic factors, and is therefore subject to multivariate constraint and selection. We emphasize three key advantages of studying metabolic rate within a quantitative genetics framework: its formalism, and its predictive and comparative power. We make several recommendations when applying a quantitative genetics framework: (i) measuring selection based on actual fitness, rather than proxies for fitness; (ii) considering the genetic covariances between metabolic rates throughout ontogeny; and (iii) estimating genetic covariances between metabolic rates and other traits. A quantitative genetics framework provides the means for quantifying the evolutionary potential of metabolic rate and why variance in metabolic rates within populations might be maintained.
Diagnostic accuracy of 18F-FDG PET or PET/CT for the characterization of adrenal masses: a systematic review and meta-analysis
Authors: Kim Seong-Jang , Lee Sang-Woo , Pak Kyoungjune , Kim In-Ju , Kim Keunyoung 
Published: January 2018

Objective:
We aimed to explore the role of the diagnostic accuracy of 18F fluodeoxyglucose PET (18F-FDG PET) or PET/CT for characterization of adrenal lesions through a systematic review and meta-analysis.

Methods:
The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through 30 April 2017, were searched for studies evaluating the diagnostic performance of 18F-FDG PET or PET/CT for characterization of adrenal lesions. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR + and LR–), and constructed summary receiver operating characteristic curves.

Results:
Across 29 studies (2421 patients), the pooled sensitivity for 18F-FDG PET or PET/CT was 0.91 [95% CI (0.88–0.94)] with heterogeneity (χ 2 = 141.8, p = 0.00) and a pooled specificity of 0.91 [95% CI (0.87–0.93)] with heterogeneity (χ 2 = 113.7, p = 0.00). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 9.9 [95% CI (7.1–13.7)] and negative likelihood ratio (LR–) of 0.09 [95% CI (0.07–0.13)]. The pooled diagnostic odds ratio was 105 [95% CI (63–176)]. In metaregression analysis, study design, publication year, study location (western vs others), interpretation criteria of PET or PET/CT images, quantification of PET or PET/CT [SUVmax (maximum standardized uptake value) vs SUV (standardized uptake value) ratio], patient group, and analysis method (patient-based vs lesion-based) were the sources of the study heterogeneity. However, in multivariate metaregression, no definite variable was the source of the study heterogeneity.

Conclusion:
18F-FDG PET or PET/CT demonstrated good sensitivity and specificity for the characterization of adrenal masses. At present, the literature regarding the use of 18F-FDG PET or PET/CT for the characterization of adrenal masses remains still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of 18F-FDG PET or PET/CT characterization of adrenal masses.

Advances in knowledge:
18F- FDG PET or PET/CT showed good sensitivity and specificity for the characterization of adrenal masses and could provide additional information for that purpose.
Εκκοσμίκευση και φύλο στην Ελλάδα: Οι «αντιστάσεις» της Ορθόδοξης Εκκλησίας
Authors: Παπαγεωργίου Νίκη 
Published: January 2018

Η διεύρυνση της εκκοσμικευτικής διαδικασίας κατά τη διάρ­κεια της μεταπολιτευτικής περιόδου ο­δηγεί στην καθιέρωση μιας σειράς νομοθετικών αποφάσεων, οι οποίες αφορούν γενικότερα το οικογενειακό δίκαιο και κα­τοχυρώνουν την ισό­τη­τα των φύλων. Η διαδικασία αυτή αντιμετωπίζει τις ενστά­σεις της Ορθόδοξης Εκκλησίας, η οποία παρεμβαίνει με ποικίλους τρό­πους με στόχο τη διατήρηση της παραδοσιακής κοινωνικής τάξης. Στο άρθρο αυτό διερευνάται η στά­ση της θε­σμικής Εκκλησίας απέναντι στην ισότητα των φύ­λων και την αναγνώ­ρι­ση των δι­και­ω­μά­των των γυναικών, κατά τη διάρκεια της μεταπολιτευτικής περιόδου στην Ελλάδα, με βάση τον επίσημο εκκλη­σι­α­στι­κό λόγο, ο οποίος εκ­φέρεται διά των εγκυκλίων της Ιεράς Συ­νό­δου.
Natural hybrid of ♀ Diplodus cervinus and ♂ of D. levantinus (Teleostei: Sparidae) from the Mediterranean coast of Israel
Authors: GOLANI DANIEL , FRICKE RONALD , TIKOCHINSKI YARON 
Published: January 2018

A morphomeristic and genetic analysis of an unusual specimen of Diplodus (Family: Sparidae) that was collected in the Mediterranean coast of Israel revealed that it is a hybrid of Diplodus cervinus female and D. levantinus male. Coloring, lip formation and teeth arrangement were intermediate between the parental species.
Genesis of a UK Faculty of Clinical Informatics at a time of anticipation for some, and ruby, golden and diamond celebrations for others
Authors: De Lusignan Simon , Barlow Jeremy , Scott Philip J. 
Published: January 2018

This Editorial marks the launch of the UK Faculty of Clinical Informatics (FCI) at the time when non-clinically qualified informaticiance are anticipating the lauch of the Federation of Informatics Professionals in Health and Care (Fed-IP).
The Multimorbidity Cluster Analysis Tool: Identifying Combinations and Permutations of Multiple Chronic Diseases Using a Record-Level Computational Analysis
Authors: Nicholson Kathryn , Bauer Michael , Terry Amanda , Fortin Martin , Williamson Tyler , Thind Amardeep 
Published: January 2018

Introduction: Multimorbidity, or the co-occurrence of multiple chronic health conditions within an individual, is an increasingly dominant presence and burden in modern health care systems. To fully capture its complexity, further research is needed to uncover the patterns and consequences of these co-occurring health states. As such, the Multimorbidity Cluster Analysis Tool and the accompanying Multimorbidity Cluster Analysis Toolkit have been created to allow researchers to identify distinct clusters that exist within a sample of participants or patients living with multimorbidity. Development: The Tool and Toolkit were developed at Western University in London, Ontario, Canada. This open-access computational program (JAVA code and executable file) was developed and tested to support an analysis of thousands of individual records and up to 100 disease diagnoses or categories. Application: The computational program can be adapted to the methodological elements of a research project, including type of data, type of chronic disease reporting, measurement of multimorbidity, sample size and research setting. The computational program will identify all existing, and mutually exclusive, combinations and permutations within the dataset. An application of this computational program is provided as an example, in which more than 75,000 individual records and 20 chronic disease categories resulted in the detection of 10,411 unique combinations and 24,647 unique permutations among female and male patients. Discussion: The Tool and Toolkit are now available for use by researchers interested in exploring the complexities of multimorbidity. Its careful use, and the comparison between results, will be valuable additions to the nuanced understanding of multimorbidity.
Quality of life in children with congenital heart disease after cardiac surgery
Authors: Atmadja Sindy , Tobing Tina Christina , Evalina Rita , Sofyani Sri , Ali Muhammad 
Published: January 2018

Background Major achievements in congenital heart disease (CHD) treatment over the past 20 years have altered the course and prognosis of CHD. Improvement of quality of life (QoL) is now a major goal of CHD treatment.Objective To assess the QoL in children after cardiac surgery for CHD.Methods A cross-sectional study was performed in children aged 2 to 18 years. The case group had 20 children with a history of corrective heart surgery in the 12 months prior to the study. The control group had 20 healthy children, age-matched to the case group. The QoL of both groups was assessed by Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales. The same post-operative children were also assessed with the PedsQL Cardiac Module. Data were analyzed using T-test with P < 0.05 as the level of significance.Results This study recruited 40 subjects: 20 post-operative and 20 healthy children. PedsQL Generic Core Scales assessment showed significant differences between groups in the physical function parameter of QoL (P<0.05) in children aged 13-18 years, but there were no significant differences in the social, emotional, and school function parameters. In children aged 2-12 years, there were no significant differences in physical, social, emotional, or school parameters. The PedsQL Cardiac Module assessment revealed that 35% of post-operative children was at risk for physical appearance problems, 80% was at risk for anxiety problems, 40% was at risk for cognitive problems, and 80% was at risk for communication problems.Conclusion Thirteen to 18-year-old children with non complex CHD have poorer physical function than healthy children. Post operative children are at risk for physical appearance, anxiety, cognitive, and communication problems.
Analisis Penyebab Masyarakat Tetap Tinggal di Kawasan Rawan Bencana Gunung Merapi (Studi di Lereng Gunung Merapi Kecamatan Cangkringan, Kabupaten Sleman Daerah Istimewa Yogyakarta)
Authors: Widodo Dwi Rustiono , Nugroho Sutopo Purwo , Asteria Donna 
Published: January 2018

Penelitian ini bertujuan untuk memetakan faktor-faktor yang menyebabkan masyarakat tetap tinggal di Kawasan Rawan Bencana (KRB) III Gunung Merapi. Penelitian ini dilakukan dengan pendekatan mixed method. Penentuan jumlah responden dengan rumus Slovin dengan batas toleransi 7 persen dan terpilih sebanyak 151 responden. Analisis yang digunakan untuk mengetahui faktor-faktor yang menyebabkan masyarakat tetap tinggal di daerah rawan bencana menggunakan analisis deskriptif statistik. Hasil penelitian menunjukkan bahwa sebesar 61,6 persen masyarakat merasa nyaman dan tenteram tetap tinggal di daerahnya meski daerahnya rawan bencana. Kenyamanan ini dikarenakan faktor lingkungan, ekonomi, dan sosial. Faktor lingkungan terutama kesuburan tanah, potensi pasir, kerikil dan batu. Sebanyak 56,9 persen penduduknya berpenghasilan lebih besar dari upah minimum regional kabupaten yang sebesar 1,4 juta rupiah per bulan. Sebanyak 92,7 persen mereka mempunyai kerabat yang masih tinggal di satu lokasi dan 95,4 persen aktif dan ikut serta dalam kegiatan kemasyarakatan seperti arisan, pengajian, dan perkumpulan lainnya.Kata kunci: Bencana, Erupsi, Kesiapsiagaan, Kawasan Rawan BencanaEnglish Title: Analysis the Causes That Make People Remain in Disaster Prone Area of Mount Merapi (Study in Mount Merapi Slope of Cangkringan Subdistrict, Sleman District, Yogyakarta Special RegionABSTRACTThis study aims to map the factors that cause people to stay in Disaster Prone Areas (KRB) III of Mount Merapi This research is conducted by mixed method approach. Determination the number of respondents carried out by Slovin formula with a tolerance limit of 7 percent and selected 151 respondents. Determination the factors that cause people to stay in disaster prone areas using descriptive analysis. The results showed that 61.6 percent of people feel comfortable and peaceful stay in their area despite the disaster-prone areas. This convenience is due to environmental, economic, and social factors. Environmental factors, especially soil fertility, the potential of sand, gravel, and stone. 56.9 percent of the population earns more than the district minimum wage of 1.4 million rupiahs per month. About 92.7 percent of them have relatives who still live in one location and 95.4 percent active and participate in community activities such as arisan, pengajian, and other associations.Keywords: Disaster, Eruption, Preparedness, Disaster prone areaCitation: Widodo, D.R., Nugroho, S.P, dan Asteria, D. (2017). Analisis Penyebab Masyarakat Tetap Tinggal di Kawasan Rawan Bencana Gunung Merapi (Studi di Lereng Gunung Merapi Kecamatan Cangkringan, Kabupaten Sleman Daerah Istimewa Yogyakarta). Jurnal Ilmu Lingkungan, 15(2),135-142, doi:10.14710/jil.15.2.135-142
Study of Dendrimers by Topological Indices
Authors: Soleimani Najmeh , Bahnamiri Shila Banari , Nikmehr Mohammad Javad 
Published: January 2018

Abstract
In this paper, five degree based topological indices, the first Zagreb (M
1), second Zagreb (M
2), first multiple Zagreb (PM
1), second multiple Zagreb (PM
2), and the hyper Zagreb (HM) indices of two types of dendrimers are studied. In addition, two distance based topological indices, the total eccentricity (θ) and eccentric connectivity (ξc
) indices of these dendrimers are computed.
The analysis of the available technologies of exploiting and applying biohydrocarbons for fuel production Part II
Authors: Gielo-Klepacz Halina , Karp Grażyna , Dzięgielewski Wojciech 
Published: January 2018

Abstract
The article described the possibilities of using biohydrocarbons as self-ignition fuels, aircraft or automotive fuel components on the basis of the biotechnology implemented in the industry.
Use of a composite repair patches to repair the upper air intake flap for the MiG-29 aircraft engine
Authors: Sałaciński Michał , Stefaniuk Michał , Synaszko Piotr , Lisiecki Janusz 
Published: January 2018

AbstractThe Composite Patch Bonded Repair (CPBR) is one of the most cost-efficient types of aircraft structure repair. In the CPBR, the damaged structure is reinforced by applying a composite patch. The boron-epoxy composite (BFRP) is a popular choice for these types of repair. The BFRP was utilized to repair the cracked resistance welding joints in the upper flap of the MiG-29’s RD-33 engine intake. In the present paper, the numerical results are shown, along with the comparative tests of the undamaged inlet flap, the damaged inlet flap and of the CPBR repaired inlet flap.
The Boquillas Formation of the Big Bend National Park, Texas, USA, a reference Cenomanian through Santonian (Upper Cretaceous) carbonate succession at the southern end of the Western Interior Seaway
Authors: Cooper Dee Ann , Cooper Roger W. , Stevens James B. , Stevens M.S. , Cobban William A. , Walaszczyk Ireneusz 
Published: January 2018

Abstract
The upper lower Cenomanian through middle Santonian (Upper Cretaceous) of the Boquillas Formation in the Big Bend Region of Trans-Pecos Texas consists of a marine carbonate succession deposited at the southern end of the Western Interior Seaway. The Boquillas Formation, subdivided into the lower, c. 78 m thick limestone-shale Ernst Member, and the upper, c. 132 m thick limestone/chalk/marl San Vicente Member, was deposited in a shallow shelf open marine environment at the junction between the Western Interior Seaway and the western margins of the Tethys Basin. Biogeographically, the area was closely tied with the southern Western Interior Seaway. The richly fossiliferous upper Turonian, Coniacian and lower Santonian parts of the Boquillas Formation are particularly promising for multistratigraphic studies.