bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Selection and Result of AVM treatment
Authors: Negoro M. , Miyachi S. , Hattori T. , Okamoto T. , Fukui K. , Fukasaku KA. , Iwakoshi T. , Yoshida J. 
Published: January 2017

The treatment selection for cerebral arteriovenous malformation (AVM) still is in controversy. In order to find out the best way to treat AVM, we summarized the treatment result of AVM patients in our hospital. Sixty-three AVM patients who had been treated at Nagoya University Hospital since 1988 to 1997 were studied. The patient characteristics were nearly the same as other reported series. The treatment modalities include surgery, embolization and radiosurgery. Rate of nidus disappearance was assessed in each treatment. Highest rate was observed in surgery or surgery with embolization. But new neurological deficits were seen in 37% of the patients of same group. Nidus occlusion rate was not high in radiosurgery with embolization, but low in complication rate. The result showed the importance of embolization procedure in the treatment selection of AVM. The value of functional MRI as pre-therapeutic study is high in those patients whose AVM adjacent to eloquent area.
The Role of Intravascular Embolization Prior to Radiosurgery of Cerebral Arteriovenous Malformations
Authors: Inoue H.K. , Nagaseki Y. , Naitou I. , Negishi M. , Hirato M. , Shibazaki T. , Ohye C. , Andou Y. 
Published: January 2017

The role of intravascular embolization prior to radiosurgery of cerebral arteriovenous malformations was evaluated based on the basis of the results of gamma knife radiosurgery in relation to hemorrhage and early obliteration after treatment. Nine of 213 patients experienced hemorrhage 4 to 42 months after radiosurgery. All AVMs in these patients had dilated feeding arteries, and the flow of the AVM was rapid and/or high. An intranidal aneurysm was seen in one patient. Drainage of all AVMs consisted of a single and/or deep draining veins, and venous obstruction was found in six. Sixty-three of 87 patients followed for more than four years after radiosurgery were examined angiographically, and total obliteration of AVM was observed in 52 of them (82.5%). Early obliteration was found in 19 of the 34 patients examined within 12 months. The obliteration rate was significantly higher in slow- and low-flow AVMs (73.9%) than in rapid- and/or high-flow AVMs (18.2%). It is concluded that the role of intravascular embolization prior to radiosurgery is not only decreasing the size of the AVM but decreasing the risk of hemorrhage and shortening the latency period by decreasing their flow rate and flow volume.
Hemodynamic Perturbations in Cerebral Arteriovenous Malformations and Management Implications
Authors: Hacein-Bey L. , Young W.L. 
Published: January 2017

Cerebral AVMs have high flow, low resistance shunts that induce regional hemodynamic disturbances and possibly neural derangements. A better understanding of these mechanisms may help treatment planning and the management of complications after endovascular or surgical treatment. Although the precise mechanisms of hemodynamic perturbation are still relatively unclear, the presence of chronic cerebral hypoperfusion is central and widely believed to be associated with both neurological deficits at presentation (‘steal‘) and ‘hyperemic’ complications following shunt obliteration. The ‘normal perfusion pressure breakthrough‘ (NPPB) theory states that chronic hypoperfusion around AVMs induces the loss of autoregulatory capability; following AVM shunt obliteration, perfusion pressure elevation induces an increase in flow, due to ‘vasomotor paralysis’, which can cause hemorrhage. The ‘dissociative vasoparalysis' theory suggests that vasodilation is preserved but not vasoconstriction. However, pharmacologic exploration of cerebral autoregulation with induced vasoconstriction (phenylephrine) and vasodilatation (acetazolamide) helps identify 3 patterns of autoregulatory behavior. The vast majority of AVM patients appear to retain autoregulatory capability, despite low arterial feeding pressures, consistent with a “shift to the left” of the autoregulation curve. Pronounced hypotension may “exhaust” cerebrovascular reserve in some patients, predisposing to hemorrhagic complications in the post-operative period. Lastly, “vasoparalysis” may coexist with a combination of vascular insult and marked hypotension. Clinical presentation, AVM angioarchitecture and peri-operative physiologic data (especially feeding artery and venous outflow pressures) may assist patient management. Patients can be identified in whom staged treatment is recommended initially. Following AVM obliteration, the patient's hemodynamic response, which may range from a minimal increase in A-V pressure gradient to significant CBF increase may be predicted, and blood pressure, fluid and ICP management adjusted accordingly, as the monitoring of post-operative cerebral hemodynamics remains difficult. Extreme attention to endovascular and operative technique must be exercised, as technical problems can be devastating. Although incompletely understood, hemodynamic derangements associated with cerebral AVMs increasingly appear to be associated with intact cerebral autoregulation in most patients. As cerebral hemodynamics monitoring remains challenging, clinical, angiographic and physiologic data from interventional/operative monitoring must be used to guide patient management.
Intra-aneurysmal GDC Embolization for Ruptured Aneurysm in the Acute Stage
Authors: Ezura M. , Takahashi A. , Yoshimoto T. 
Published: January 2017

This study focused on our experiences in intra-aneurysmal embolization for ruptured aneurysm in the acute stage. Clinical materials of this study consist of 37 patients who were treated with intra-aneurysmal GDC embolization within 72 hours after the onset of subarachnoid hemorrhage from December 1995 to July 1998. Patients with cerebral aneurysms are always examined as possible candidates for neurosurgical clipping. If the patient had any difficulties and/or problems on neurosurgical clipping (high age 22, poor grade 15, surgically difficult location 9, systemic disease 3), the patient was treated by intra-aneurysmal GDC embolization. GDCs were inserted as tight as possible. Then, spinal drainage was set in patients with thick subarachnoid hemorrhage. Tissue plasminogen activator was administered via the drainage in patients with thicker subarachnoid hemorrhage. One patient experienced rerupture during peritherapeutic period. Symptomatic vasospasm was observed in three patients (8.1%). Good outcome was obtained in 26 out of 30 surviving patients. Symptomatic complication caused by distal embolism occurred in two patients. In conclusion, intra-aneurysmal GDC embolization is thought to be sufficient regarding prevention of rerupture, incidence of vasospasm, and clinical outcome.
Comparison of Clinical Results between GDC Treatment and Direct Surgery for Ruptured Cerebral Aneurysms
Authors: Fukui K. , Miyazaki M. , Hattori K. , Osawa H. , Miyachi S. , Negoro M. , Yoshida J. 
Published: January 2017

We present a comparison of clinical results between GDC treatment and direct surgery for ruptured cerebral aneurysms. From May 97 to April 98, 32 aneurysms were treated by direct surgery (DS) or GDC treatment. Treatments were selected depending on the clinical grade, degree of hematoma and anatomical aspect of the aneurysms. There were 13 GDC treated cases and 19 direct surgery cases. In GDC cases, there were acute stage embolization for ruptured basilar aneurysm, recurrence of case after clipping for BA-SCA aneurysm, advanced age cases, and systemic complication cases. Glasgow outcome scale (GOS) in GDC cases were 8 GR, 2 MD and 3 SD. GOS in direct surgery cases were 7 GR, 4 MD, 4 SD and 4 deaths. Cases of severe subarachnoid hemorrhage with hematoma influenced the high death rate in direct surgery group. There were three complications associated with the procedure in the GDC group, however, the rate improved after advancement of the procedure. In conclusion, GDC treatment for ruptured cerebral aneurysm was satisfactorily acceptable compared to the results of direct surgery, however, more cases will be needed for precise comparison.
Development of Biologically Active GDC for the Treatment of Cerebral Aneurysms
Authors: Murayama Y. , Viñuela F. , Suzuki Y. , Akiba Y. , Duckwiler G.R. , Gobin Y.P. , Kaibara M. , Kurotobi K. , Iwaki M. , Abe T. 
Published: January 2017

In Vitro Study: The surface of polystyrene dishes were treated either by: 1) collagen coating without ion implantation, or 2) collagen coaling with ion implantation. Ne+implantation was performed on area 2 with fluences of 1 times 1015at an energy of 150 keV. Bovine endothelial cells were cultured on the dishes and the resistance to detachment of cells was evalated with trypsin treatment. Experimental Aneurysm Study: GDCs were coated with either type 1 collagen, fibronectin, vitronectin, laminin or fibrinogen. Ion implantation was then performed on these protein-coated GDCs. 56 experimental aneurysms were constructed microsurgically in the bilateral common carotid arteries of 28 swine. The aneurysms were embolized with standard GDCs or with ion-implanted protein-coated GDCs. The animals were sacrificed at day 14 after coil placement. The aneurysmal orifice was observed microscopically. In vitro study showed that endothelial cell proliferation and strength of cell attachment were accerelated by ion implantation. On specimens examined 14 days post-embolization, greater fibrous tissue coverage at the neck of the aneurysm was observed macroscopically and microscopically with ion implanted GDCs, whereas only a fibrin-like thin layer covered the standard GDC surfaces. These in vitro and in vivo studied indicate that ion implantation combined with protein coating of GDCs improves cellular adhesion/proliferation. This technology may provide an improvement in clinical outcome of cerebral aneurysms.
Modification of Immediately Electrically Detachable Coil
Authors: Sadato A. , Ogawa A. , Taki W. , Iwata H. , Oowaki H. , Aoki T. , Isaka F. , Sato T. , Hashimoto N. 
Published: January 2017

An immediately electrically detachable coil (IEDC) that we previously developed was modified to enhance the reliability in its detachment system. IEDC is detached by applying a monopolar high-frequency electrical current that heat and disrupt a junction between a platinum coil and a delivery wire. The original IEDC immediately detaches only when the junction is just outside the catheter tip and precise positioning of the junction is required. In the modified IEDC Its delivery wire was insulated with polytetra fluoroethylene (PTFE) to concentrate electrical current to the junction. The modified IEDC was tested in vitro and in animal experiments. Modified IEDC always detached instantaneously even when the junction was far beyond the catheter tip. Insulated delivery wire enabled the electrical current to be concentrated at the PVA junction and produce appropriate heat to disrupt the junction.
Pre-Embolization Study of Ruptured Cerebral Aneurysms with Helical CT
Authors: Nomura M. , Kida S. , Uchiyama N. , Yamashima T. , Yamashita J. , Yoshikawa J. , Matsui O. 
Published: January 2017

Sixteen ruptured aneurysms in 16 patients considered endovascular embolizations were examined. The findings of axial source images (axial images) and reconstructed three-dimensional CT angiography (3D-CTA) of helical CT were compared to those of rotational digital subtraction angiography (DSA). The aneurysmal neck and arterial branches adjacent to the neck were closely investigated. In seven out of 16 cases (43.8%), information provided by axial images and/or 3D-CTA was more useful than that of rotational DSA in evaluating the aneurysmal neck and arterial branches. Helical CT can provide valuable information on ruptured aneurysms that cannot be obtained by rotational DSA in some patients. This technique is useful to obtain anatomical information about aneurysms and to select the best therapeutic method.
Churg-Strauss Syndrome Development during Asthma Therapy with Leukotriene Receptor Antagonists: Just a Coincidental Association?
Authors: De Nardo D. , De Sanctis G. , Biancone L. , Khalil J. , Kroegler B. , De Risi E. , Franconi G. , Capria A. , Fontana L. 
Published: January 2017

A report on our clinical experience based on 3 male patients who developed Churg-Strauss syndrome (CSS) after standard oral montelukast use. All patients affected by moderate asthma and chronic hyperplastic rhinosinusitis were treated with inhaled corticosteroids and ß2 agonists. Systemic corticosteroid treatment consisted in oral daily prednisone in case 1, in short courses of oral betamethasone in case 2, and in remote and isolated administrations of oral betamethasone and intramuscular methylprednisolone in case 3. Because of the improvement of the asthma symptoms after montelukast use, patient 1 decided to take half the dose of prednisone for 10 days and patient 2 decided to discontinue systemic and inhaled corticosteroids for 45 days. Overt CSS was heralded by vasculitic skin lesions and developed in each patient with severe organ damage, consisting in renal, myocardial and gastrointestinal involvement. Remission was obtained by standard CSS therapy after montelukast withdrawal. According to the unmasking hypothesis, antileukotriene treatment, by enabling the reduction in systemic corticosteroid therapy in case 1 and its discontinuation in case 2, might have only permitted the precipitation of the vasculitis. However antileukotriene-associated CSS reportedly occurred in systemic corticosteroid-naïve patients and relapsed in one patient after antileukotriene treatment. These observations lend support to the concept that the precipitation of the vasculitic phase may be associated with leukotriene modifier deleterious effects. In conclusion there is not enough evidence to prove that antileukotriene treatment plays a direct causative role in the pathogenesis of CSS. Further clinical and experimental research is required to clarify the antileukotriene associated CSS controversy.
Deflation versus maintained inflation of gastric band in pregnancy: A national cohort study
Authors: Jefferys Amanda , Lenguerrand Erik , Cornthwaite Katie , Johnson Andrew , Lynch Mary , Hyde Judith , Draycott Tim , Siassakos Dimitrios 
Published: January 2017

Background With no evidence to guide management of the gastric band in pregnancy, we aim to compare outcomes according to band management. Methods Data were collected on all women pregnant (November 2011–October 2012) following gastric banding, using the UK Obstetric Surveillance System surveillance system. We compared outcomes between band management groups and with national data. Results Band management was variable; deflation 43.4%, inflation maintained 56.6%. The deflation group had lower risk of small for gestational age infants (no cases vs. 11.3%; risk ratio = 0.14, p = 0.05). There was greater gestational weight gain (deflation 15.4 kg, inflation 7.6 kg; adjusted p = 0.05), and perhaps higher risk of gestational hypertension (deflation 10.5%, inflation no cases; p = 0.08) in the deflation group. Other maternal outcomes were similar between management groups but overall worse than national data. Conclusions Deflation is associated with better outcomes for babies but worse outcomes for mothers than maintained inflation.
Impact of Neurological Follow-Up on Early Hospital Readmission Rates for Acute Ischemic Stroke
Authors: Allen Alexander , Barron Todd , Mo Ashley , Tangel Richard , Linde Ruth , Grim Rodney , Mingle John , Deibert Ellen 
Published: January 2017

Introduction: Despite advances in stroke care, readmission rates for patients with ischemic stroke remain high. Although factors such as age, diabetes, and continuous use of antiplatelet agents have been found to predict readmission rates, the impact of after-hospital care has not been examined. Methods: The present study reviewed the charts of 416 patients with acute ischemic stroke and recorded stroke-related comorbidities, neurology follow-up within 21 days, readmission at 0 to 30 days, readmission at 31 to 90 days, and any reasons for readmission. Results: For those readmitted within 0 to 30 days, reasons for readmission were other medical conditions (62.5%), recurrent stroke (30.4%), and elective procedure (7.1%). For those readmitted within 31 to 90 days, reasons for readmission were other medical conditions (62.3%), recurrent stroke (15.1%), and elective procedure (22.6%). There was no significant relationship between being evaluated within 21 days and readmission at 0 to 30 or 31 to 90 days. However, those who did have a neurology follow-up at any point in time had a lower readmission rate of 10.6% compared to those who never came back (19.2%, P = .017). Patients with coronary artery disease and diabetes had a significantly higher likelihood of readmission within 0 to 30 days. Conclusion: The present study suggests that neurology follow-up at any point in time for patients with acute ischemic stroke may reduce short-term readmissions, but special attention to optimizing management of other underlying medical conditions, coronary artery disease, or diabetes may also help reduce overall readmissions. Patients with stroke, therefore, may benefit from a follow-up with both the primary care and neurology in a coordinated fashion to prevent early readmissions at 30 days.
Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells
Authors: Kunimoto Hiroyoshi , McKenney Anna Sophia , Meydan Cem , Shank Kaitlyn , Nazir Abbas , Rapaport Franck , Durham Benjamin , Garrett-Bakelman Francine E. , Pronier Elodie , Shih Alan H. , Melnick Ari , Chaudhuri Jayanta , Levine Ross L. 
Published: January 2017

Key Points
Aid loss leads to altered differentiation, transcription, and methylation in specific genetic loci in hematopoietic stem/progenitor cells. Aid loss does not contribute to enhanced HSC self-renewal or cooperate with Flt3-ITD in myeloid leukemogenesis.
Nomenclature of Tokyo cherry (Cerasus × yedoensis 'Somei‐yoshino', Rosaceae) and allied interspecific hybrids based on recent advances in population genetics
Authors: Katsuki Toshio , Iketani Hiroyuki 
Published: January 2017

AbstractThe flowering cherries, Cerasus (≡Prunus subg. Cerasus; Rosaceae), including C. × yedoensis 'Somei‐yoshino', are popular ornamental trees in temperate regions of the world. Recent advances in molecular and population genetics have revealed that this group originated as an interspecific hybrid. We used these findings and the verification of type specimens to examine the nomenclature of nothotaxa including C. × yedoensis. Four nothotaxa, C. × yedoensis, C. × nudiflora , C. × sacra and C. × kashioensis, were confirmed to be hybrids resulting from crosses between C. itosakura and taxa of the C. serrulata complex (C. speciosa, C. sargentii, C. jamasakura and C. leveilleana, respectively). In addition, the hybrids found on Jeju Island are C. × nudiflora, a new combination for an interspecific hybrid shown to be genetically distinct from C. × yedoensis. A new nothospecies, C. × kashioensis is proposed for a hybrid between C. itosakura and C. leveilleana.
Effects of physicochemical factors on seasonal variations of phytoplankton in the Mond River Estuary of Bushehr Province, Persian Gulf, Iran
Authors: POULADI MOJTABA , QADERMARZI AMIR , BAHARVAND FATEMEH , VAZIRIZADEH AMIR , HEDAYAT ALIAKBAR 
Published: January 2017

Abstract. Pouladi M, Qadermarzi A, Baharvand F, VazirizadehA, Hedayati A. 2017. Effects of physicochemical factors on seasonal variations of phytoplankton in the Mond River Estuary of Bushehr Province, Persian Gulf, Iran. Biodiversitas 18: 229-237. The main purpose of present study was to investigate the abundance and biodiversity of phytoplankton from Mond estuary, Bushehr, Persian Gulf during different seasons and its relationships with environmental parameters and nutrients. Samples were taken in mid-season from spring 2012 to winter 2013 for oneyear period. The phytoplankton were contributed by the phyla Bacillariophyta, Dinophyta, Haptophyta, and Chlorophyta. The class Coscinodiscophyceae and Bacillariophyceae belonging to Bacillariophyta were the most diverse and dominant with 22 and 16 genera, respectively. The mean phytoplankton abundance were recorded in spring (12706.7Â±3586.9 cells L-1), in summer (10173.3Â±2560.08 cells L-1), in autumn (10600Â±2758.2 cells L-1) and in winter (7000Â±2401.6 cells L-1), respectively. Simpson and Shannon-Wiener biodiversity indices obtained showed in spring (0.93Â±0.007 and 3.8Â±0.2), in summer (0.92Â±0.008 and 3.64Â±0.2), in autumn (0.92Â±0.006 and 3.63Â±0.15) and in winter (0.89Â±0.013 and 3.07Â±0.24), respectively. The phytoplankton assemblages were most diverse and abundant at station-5 in all seasons. In addition, there were significant correlation (P<0.01) between phytoplankton abundance and diversity with pH, salinity, NO3, PO4 and temperature. Based on Principle Component Analysis (PCA), the most important factors that could describe most changes of abundance and diversity of phytoplankton in the Mond River estuary system were salinity, NO3, pH, PO4 and temperature, respectively. Results demonstrated that diatoms were the dominant population and salinity factor was more effective factor that affected the diversity and abundance of phytoplankton during study period in Mond River estuary.
Keywords: Abundance, Bushehr, diversity, Mond River Estuary, phytoplankton, Persian Gulf
Pemberian Antitrombin III pada Sepsis Neonatal
Authors: Septhiandi Nathanne , Pudjiadi Antonius , Amalia Pustika 
Published: January 2017

Latar belakang. Kadar antitrombin III (AT III) dalam darah rendah pada pasien sakit berat dan penurunan kadarnya berkorelasi dengan derajat penyakit. Fungsi AT III sebagai antikoagulan, mempunyai peran penting untuk mencegah disfungsi mikrovaskular dan mengakibatkan kerusakan multi organ pada sepsis. Namun, peran teurapetik AT III pada sepsis masih diperdebatkan.Tujuan. Melakukan evaluasi apakah pemberian AT III pada sepsis neonatal berat memiliki prognosis yang lebih baik bila dibandingkan dengan plasebo.Metode. Penelusuran pustaka database elektronik yaitu Pubmed, Highwire, Google dan Yahoo.Hasil. Didapatkan 12 artikel yang dianggap relevan dengan rumusan masalah, terdiri atas 3 meta-analisis, 8 randomized controlled trial (RCT), dan 1 review. Hasil meta-analisis pertama menyatakan bahwa pemberian preparat AT III aman dan dapat ditoleransi dengan baik. Dilaporkan AT III menurunkan tingkat mortalitas 22,9% pada hari ke-30 pasca intervensi. Hasil meta-analisis keduamendapatkan pemberian AT III tidak menurunkan risiko mortalitas secara keseluruhan (RR 0,96, IK95%: 0,89;1,03), dan meningkatkan risiko perdarahan (RR 1,52, IK95%: 1,3;1,78). Hasil meta-analisis ketiga menunjukkan pemberian AT III mengurangi risiko mortalitas dalam 28 sampai 30 hari (OR 0,649, IK95%: 0,422; 0,998). Risiko perdarahan pada kelompok AT III tidak berbeda signifikan dengan kelompok plasebo.Kesimpulan. Secara statistik penggunaan AT III apabila dibandingkan dengan plasebo pada keadaan sepsis neonatal tidak memperbaiki prognosis dalam hal menurunkan tingkat mortalitas selama 28-30 hari. Walaupun demikian, tingkat mortalitas kelompok AT III lebih rendah dibandingkan dengan placebo.