bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rice Response to Struvite and Other Phosphorus Fertilizers in a Phosphorus-Deficient Soil Under Simulated Furrow-irrigation
Authors: Brye Jonathan B. , Lunga Diego Della , Brye Kristofor R. 
Published: October 2024

AbstractWastewater-recovered phosphorus (P), in the form of the mineral struvite (MgNH4PO4⋅6H2O), may provide a sustainable alternative to decreasing rock-phosphate reserves. Struvite can be generated via precipitation methods, potentially reducing the amount of P runoff to aquatic ecosystems. The objective of this greenhouse tub study was to evaluate the effects of chemically- and electrochemically precipitated struvite (CPST and ECST, respectively) on above- and belowground plant response in a hybrid rice (Oryza sativa) cultivar grown using furrow-irrigation compared to other common fertilizer-P sources [i.e., triple super phosphate (TSP) and diammonium phosphate (DAP)]. Rice was grown in tubs in controlled environmental conditions in a greenhouse for a full growing season in a P-deficient, silt-loam soil (Typic Glossaqualfs). Plant nutrients (i.e., N. P. K. Mg, Zn) were determined at the end of the growing season through Mehlich-3 extraction. Below- and aboveground rice dry matter (DM), root-P concentration and uptake, aboveground tissue-P uptake, total aboveground and total plant DM, grain yield, and grain P uptake from CPST and ECST did not differ from DAP or TSP. However, aboveground tissue-P concentration was greater (P < 0.05) from TSP (0.05%) than from ECST, CPST, and the unamended control (UC). Total aboveground (i.e., vegetative plus grain) tissue-P uptake was largest (P < 0.05) from TSP (4.8 g m− 2), which did not differ from DAP or CPST, and was at least 1.1 times greater than from ECST and the UC. Despite only a few differences from the UC, the many similar rice responses among struvite and other common fertilizer-P sources suggest that struvite, especially ECST, is a potential alternative fertilizer-P source that warrants further research into struvite’s role in food production.
Exploring Complexities of Political Ecology in the Research and Practice of Environmental Education
Authors: Hart Paul 
Published: October 2024

AbstractThis paper explores educational fallout from the realisation that the world system has planetary boundaries as limits that are real and that require different thinking and governance concerning how human beings ought to inhabit the planet. It will be difficult to have billions of people think about global concerns when they are focused on their own well-being. And so it comes to governance, locally, with bigger things in mind. Environmental education rhetoric has already begun to expand thinking to engage world systems as groundings for the politics that underpins decision-making above and beyond levels of theory/praxis. The educational challenge will be to lay out background theory and guidelines as we find ways to engage politically the problems amidst the power and control of the people that we elect as “leaders” at each level of educational and political systems. However, the challenge has been taken up and environmental education has created openings for exploring complexities of political ecology within environmental education.
Cancer Care After Türkiye-Syrian Earthquakes: A Qualitative Study
Authors: Sert Gürkan , Gözderesi Yakup , Kesen Yurtcanlı Yurtcanl Cemre Hilal , Barış Maide , Hıdıroğlu Seyhan 
Published: October 2024

Abstract

Objectives
In the field of cancer, many cancer patient associations (CPAs) have been established in Türkiye to support individuals living with cancer (ILCs) throughout the diagnosis and treatment processes. The presence of CPAs for ILCs became more significant after the major earthquakes in southeastern Türkiye in February 2023. The aim of this study is to identify the challenges of ILCs after the earthquakes from the perspective of CPA members.

Methods
This study employed a qualitative approach. The data collection method was in-depth interviews. Semi-structured, open-ended interviews were conducted with 15 volunteers who work with ILCs, selected through purposeful sampling. The data were analyzed by using inductive thematic analysis. This study was conducted between April and May 2023.

Results
Three main themes (problems of ILCs caused by earthquakes, access to health care, future concerns) and 11 subthemes were extracted through analyzing interviews.

Conclusion
ILCs experienced diverse difficulties after earthquakes. Members of CPAs observed that acute interventions to injured people and humanitarian aid activities had the first-place importance after the earthquake, while cancer-related care took the second place, anticipating devastating outcomes for the future of their care. CPAs should be supported by the public, local governments, and central government in their endeavors for ILCs.
Salivary iodine concentrations can estimate iodine intake and diagnose abnormal thyroid function: a cross-sectional study in pregnant and lactating women in iodine-deficient areas
Authors: Wang Chenchen , Tayier Rishalaiti , Nie Jiaoyang , Zhu Yuming , Muhetaer Dawureni , Mangekuli Halamulati , Lin Qin 
Published: October 2024

AbstractSalivary iodine concentrations (SIC) and urinary iodine concentrations are correlated. This study aimed to verify the use of SIC as a biomarker for estimating iodine intake in pregnant and lactating women and to diagnose abnormal thyroid function. A cross-sectional study was conducted in northern Xinjiang, China. Participants provided venous blood, random urine, saliva and milk samples. A total of 607 pregnant and 171 lactating women volunteered to participate in the study. The average daily iodine intake was calculated for each participant. Pregnant women were divided according to trimester. The median daily iodine intake was 436·41 μg/d in the first trimester, 425·83 μg/d in the second trimester and 430·56 μg/d in the third trimester. The average daily iodine intake in lactating women was 416·16 μg/d. Different indicators were used to diagnose excessive iodine intake (> 500 μg/d). Among pregnant women, SIC had an AUC of 0·62 (P < 0·01), sensitivity of 51·75 % and specificity of 65 %. Among lactating women, SIC had an AUC of 0·63 (P = 0·03), sensitivity of 43·52 % and specificity of 85 %. SIC was an effective biomarker for diagnosing abnormal thyroid function (P = 0·03). In conclusion, this study demonstrated that SIC is a reliable biomarker for evaluating both iodine nutrition status and abnormal thyroid function in pregnant and lactating women.
Return of the Eurasian lynx: using local stakeholder knowledge and experiences to inform lynx conservation in the French Alps
Authors: Alexander Justine Shanti , Christe Philippe , Zimmermann Fridolin 
Published: October 2024

Abstract
Large carnivore conservation in human-dominated landscapes is a complex issue, often marked by the stark contrast between those who hold deep-rooted animosity towards these animals and those who welcome their presence. The survival of the Eurasian lynx Lynx lynx in Europe relies on effective coexistence with humans in multi-use areas. We explored the experiences and perceptions of local hunters and pastoralists regarding the return of the lynx to the Giffre Valley, France, and mapped lynx distribution based on the probability of site use while accounting for detection probability. We conducted in-depth interviews with 29 respondents to gather data on lynx sightings, rationale for hunting and pastoralism, and perceptions of lynxes. We found that 45% of respondents had detected lynxes in the last 40 years, with an estimated site use of 0.66 ± SE 0.33 over the last decade, indicating there was a 66% probability of lynxes using the sites during that time period. Our results suggest that hunting and pastoralism in the region are rooted in a desire to carry on local traditions and connect with the natural world. Respondents generally tolerated the presence of lynxes, perceiving few threats to their livelihoods and activities, and expressing a willingness to coexist peacefully. However, some identified future challenges that could arise with the return of large carnivores to the valley and highlighted scenarios that could lead to a decline in tolerance. This study emphasizes the valuable knowledge of local hunters and pastoralists and their potential role in lynx population monitoring and conservation. Integrating stakeholder values in decision-making processes is crucial for inclusive and sustainable responses to promote biodiversity.
Preconception and prenatal vitamin D associations with positive behavioral health in Black children
Authors: Hipwell Alison E. , Keenan Kate , Tung Irene , Quick Allysa , Simhan Hyagriv , Bodnar Lisa , Buckner Nia 
Published: October 2024

AbstractBackgroundLow levels of vitamin D during pregnancy are associated with offspring behavioral problems but little is known about pre-pregnancy influences. Additionally, Black American individuals are underrepresented in studies, limiting translational impact. We tested independent and interactive effects of preconception and prenatal vitamin D in Black women in relation to positive behavioral and emotional outcomes in early childhood.MethodsBlack-identifying participants (N = 156) enrolled in the longitudinal Pittsburgh Girls Study (PGS) provided venous blood samples before and during pregnancy to measure 25-hydroxyvitamin D (25[OH]D) levels. Participants completed questionnaires assessing sociodemographic factors, depression severity and life stress, and later reported on child behavioral and emotional problems and prosocial behavior between 2 and 4 years.ResultsMean serum 25(OH)D concentrations were 15.5 ng/ml (s.d. = 7.7) before pregnancy and 18.0 ng/ml (s.d. = 9.2) during pregnancy; below the sufficiency threshold according to commonly used dietary guidelines. After adjusting for covariates, prenatal 25(OH)D was negatively related to behavior problems and positively related to prosocial behavior in children, although the association attenuated for behavior problems after accounting for preconception 25(OH)D, which may reflect patterns of stability. Maternal 25(OH)D was unrelated to child emotional problems, and no synergistic effects of 25(OH)D timing were observed for any child outcome.ConclusionsFindings have relevance for Black women living in the northeast U.S. Results suggest specific associations between maternal vitamin D and positive behaviors in early childhood, regardless of sufficiency levels and suggest potential opportunities for early interventions to support healthy child development.
Understanding consumer beliefs and choices related to food safety: a qualitative study in urban Ethiopia
Authors: Nordhagen Stella , Hagos Smret , Gebremedhin Genet , Lee James 
Published: October 2024

Abstract

Objective:
Provide an in-depth examination of consumers’ food safety beliefs and practices to draw implications for interventions to improve nutrition and food safety in Ethiopia.

Design:
Adapted Focused Ethnographic Study approach using in-person semi-structured interviews and free-listing exercises, in two iterative phases.

Setting:
A traditional food market in Hawassa, a mid-sized city.

Participants:
Forty-six market shoppers, selected randomly in line with quotas for age and gender.

Results:
Consumers did not clearly differentiate between quality and safety, seeing them through connected concepts such as ‘freshness’. While most respondents had some understanding of the causes of unsafe food, they did not generally worry about becoming ill themselves and felt food safety risks were easily mitigated through in-home behaviours. Thus, food safety practices were not a main motivator of market or vendor choice. There was no evidence that food safety concerns led consumers to prefer packaged, processed food or to avoid consuming fresh foods.

Conclusions:
The study offers novel depth and detail on a topic of strong policy relevance. While building on an encouraging base of understanding of food safety, there remains considerable scope for increasing knowledge, particularly with regard to the need to procure safe food as opposed to expecting household-level practices to mitigate all safety risks. Motivating customers to give food safety factors more consideration when making food purchasing decisions, such as by leveraging emotion-based communication from trusted messengers to elevate the issue’s salience in their minds, may contribute to improvements in food safety in low-income countries such as Ethiopia.
Resilience and coping styles in family caregivers of terminally ill patients: A cross-sectional survey
Authors: Shimizu Yoichi , Hayashi Akitoshi , Maeda Isseki , Miura Tomofumi , Inoue Akira , Takano Mayuko , Aoyama Maho , Masukawa Kento , Miyashita Mitsunori 
Published: October 2024

Abstract

Objectives
Coping styles can be improved by dyadic palliative care interventions and may alleviate patients’ and family caregivers’ distress. Moreover, family caregivers’ preloss resilience protects against depression after bereavement. This study aimed to determine the types of coping styles can be encouraged to increase resilience.

Methods
A self-reported questionnaire survey was administered to family caregivers at the 4 palliative care units, and their resilience was assessed using the Connor–Davidson Resilience Scale (CD-RISC) and their coping styles were assessed using the Brief Coping Orientation to Problem Experienced, as well as their background characteristics.

Results
Among 291 caregivers with a mean CD-RISC score of 56.2 (standard deviation: 16.13), internal locus of control, educational level, and history of psychotropic drug use were associated with resilience. After adjusting for the aforementioned factors, more frequent use of positive coping styles such as active coping (Spearman’s ρ = 0.29), acceptance (ρ = 0.29), positive reframing (ρ = 0.29), planning (ρ = 0.24), and humor (ρ = 0.18), was found to be associated with higher resilience. On the contrary, more frequent use of negative coping styles such as behavioral disengagement (ρ = −0.38), self-blame (ρ = −0.27), and denial (ρ = −0.14) was found to be associated with less resilience.

Significance of results
By assessing internal locus of control, educational level, and history of psychotropic medication use of family caregivers, as factors associated with their respective resilience, may help identify less resilient family caregivers who are at risk for developing major depression after bereavement. In addition, coping skill-based educational interventions targeting patients and their family caregivers that focus on specific coping styles associated with resilience may increase family caregivers’ resilience, resulting in less emotional distress and a lower risk of major depression after bereavement.
Chancen und Hürden der Digitalisierung
Authors: Hegedüs Anna , Hasler Melina , Domonell Kristina , Willener Daniela , Chiapparini Emanuela 
Published: October 2024

Was ist zu diesem Thema bekannt? Die Digitalisierung stellt Betroffene vor Herausforderungen. Zugangshürden erschweren die soziale Teilhabe in der Gesellschaft und mangelnde finanzielle Ressourcen fördern den digitalen Ausschluss. Wie wird eine neue Perspektive eingebracht? Wir verdeutlichen die Hürden der Digitalisierung für vulnerable Personengruppen entlang des Modells zur digitalen Gesundheitskompetenz (E-Health Literacy Framework). Was sind die Auswirkungen für die Praxis? Die Erfassung der digitalen Gesundheitskompetenz der Klient_innen ermöglicht Pflegefachpersonen individuelle Unterstützungsangebote abzuleiten, die Anwendung zu begleiten und die eigenständige Nutzung zu fördern.
Lithospheric Structure in the Northern Appalachian Mountains: A Detailed Examination of the Abrupt Change in Crustal Thickness in Northwestern Massachusetts
Authors: Masis Roberto , Long Maureen D. , Karabinos Paul , Bourke James 
Published: October 2024

AbstractPrevious geophysical studies in the New England Appalachians identified a ∼15 km offset in crustal thickness near the surface boundary between Laurentia and the accreted terranes. Here, we investigate crustal structure using data from a denser array: New England Seismic Transects experiment, which deployed stations spaced ∼10 km apart across the Laurentia‐Moretown terrane suture in northwestern Massachusetts. We used receiver function (RF) analysis to detect P to SV converted waves and identified multiple interfaces beneath the transect. We also implemented a harmonic decomposition analysis to identify features at or near the Moho with dipping and/or anisotropic character. Beneath the Laurentian margin, the Ps converted phase from the Moho arrives almost 5.5 s after the initial P wave, whereas beneath the Appalachian terranes, the pulse arrives at 3.5 s, corresponding to ∼48 and ∼31 km depth, respectively. The character of the RF traces beneath stations in the middle of our array suggests a complex transitional zone with dipping and/or anisotropic boundaries extending at least ∼30 km. This extension is measured in our profiles and perpendicular to the suture. We propose one possible crustal geometry model that is consistent with our observations and results from previous studies.
NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation
Authors: Shimosato Yuko , Yamamoto Keita , Jia Yuhan , Zhang Wenyu , Shiba Norio , Hayashi Yasuhide , Ito Shuichi , Kitamura Toshio , Goyama Susumu 
Published: October 2024

AbstractNucleophosmin (NPM1) is a nucleolar protein and one of the most frequently mutated genes in acute myeloid leukemia (AML). In addition to the commonly detected frameshift mutations in exon12 (NPM1c), previous studies have identified NPM1 gene rearrangements leading to the expression of NPM1-fusion proteins in pediatric AML. However, whether the NPM1-fusions are indeed oncogenic and how the NPM1-fusions cause AML have been largely unknown. In this study, we investigated the subcellular localization and leukemogenic potential of two rare NPM1-fusion proteins, NPM1::MLF1 and NPM1::CCDC28A. NPM1::MLF1 is present in both the nucleus and cytoplasm and occasionally induces AML in the mouse transplantation assay. NPM1::CCDC28A is more localized to the cytoplasm, immortalizes mouse bone marrow cells in vitro and efficiently induces AML in vivo. Mechanistically, both NPM1-fusions bind to the HOX gene cluster and, like NPM1c, cause aberrant upregulation of HOX genes in cooperation with XPO1. The XPO1 inhibitor selinexor suppressed HOX activation and colony formation driven by the NPM1-fusions. NPM1::CCDC28A cells were also sensitive to menin inhibition. Thus, our study provides experimental evidence that both NPM1::MLF1 and NPM1::CCDC28A are oncogenes with functions similar to NPM1c. Inhibition of XPO1 and menin may be a promising strategy for the NPM1-rearranged AML.
Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Authors: Toledano-Zaragoza Ana , Enriquez-Zarralanga Violeta , Naya-Forcano Sara , Briz Víctor , Alfaro-Ruíz Rocío , Parra-Martínez Miguel , Mitroi Daniel N. , Luján Rafael , Esteban José A. , Ledesma María Dolores 
Published: October 2024

AbstractNiemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1nmf164) we show aberrant mGluR5 lysosomal accumulation and reduction at plasma membrane in NPC1 deficient neurons. This phenotype was induced in wild-type (wt) neurons by genetic and pharmacological NPC1 silencing. Extraction of cholesterol normalized mGluR5 distribution in NPC1-deficient neurons. Intracellular accumulation of mGluR5 was functionally active leading to enhanced mGluR-dependent long-term depression (mGluR-LTD) in Npc1nmf164 hippocampal slices. mGluR-LTD was lower or higher in Npc1nmf164 slices compared with wt when stimulated with non-membrane-permeable or membrane-permeable mGluR5 agonists, respectively. Oral treatment with the mGluR5 antagonist 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (CTEP) reduced mGluR-LTD and ameliorated psychiatric anomalies in the Npc1nmf164 mice. Increased neuronal mGluR5 levels were found in an NPC patient. These results implicate mGluR5 alterations in NPC psychiatric condition and provide a new therapeutic strategy that might help patients suffering from this devastating disease.
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
Authors: Kim Young Jae , Lee Sung-Gwon , Park So Young , Jeon Sang Min , Kim Soo In , Kim Kyung Tae , Roh Taylor , Lee Sang-Hee , Lee Min Joung , Lee Jinyoung , Kim Hyeon Ji , Lee So Eui , Kim Jin Kyung , Heo Jun Young , Kim In Soo , Park Chungoo , Paik Seungwha , Jo Eun-Kyeong 
Published: October 2024

AbstractUbiquitin regulatory X (UBX) domain-containing protein 6 (UBXN6) is an essential cofactor for the activity of the valosin-containing protein p97, an adenosine triphosphatase associated with diverse cellular activities. Nonetheless, its role in cells of the innate immune system remains largely unexplored. In this study, we report that UBXN6 is upregulated in humans with sepsis and may serve as a pivotal regulator of inflammatory responses via the activation of autophagy. Notably, the upregulation of UBXN6 in sepsis patients was negatively correlated with inflammatory gene profiles but positively correlated with the expression of Forkhead box O3, an autophagy-driving transcription factor. Compared with those of control mice, the macrophages of mice subjected to myeloid cell-specific UBXN6 depletion exhibited exacerbated inflammation, increased mitochondrial oxidative stress, and greater impairment of autophagy and endoplasmic reticulum-associated degradation pathways. UBXN6-deficient macrophages also exhibited immunometabolic remodeling, characterized by a shift to aerobic glycolysis and elevated levels of branched-chain amino acids. These metabolic shifts amplify mammalian target of rapamycin pathway signaling, in turn reducing the nuclear translocation of the transcription factor EB and impairing lysosomal biogenesis. Together, these data reveal that UBXN6 serves as an activator of autophagy and regulates inflammation to maintain immune system suppression during human sepsis.
Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity
Authors: Geiselhöringer Anna-Lena , Kolland Daphne , Patt Arisha Johanna , Hammann Linda , Köhler Amelie , Kreft Luisa , Wichmann Nina , Hils Miriam , Ruedl Christiane , Riemann Marc , Biedermann Tilo , Anz David , Diefenbach Andreas , Voehringer David , Schmidt-Weber Carsten B. , Straub Tobias , Pasztoi Maria , Ohnmacht Caspar 
Published: October 2024

AbstractDendritic cells (DCs) are crucial for initiating protective immune responses and have also been implicated in the generation and regulation of Foxp3+ regulatory T cells (Treg cells). Here, we show that in the lamina propria of the small intestine, the alternative NF-κB family member RelB is necessary for the differentiation of cryptopatch and isolated lymphoid follicle-associated DCs (CIA-DCs). Moreover, single-cell RNA sequencing reveals a RelB-dependent signature in migratory DCs in mesenteric lymph nodes favoring DC-Treg cell interaction including elevated expression and release of the chemokine CCL22 from RelB-deficient conventional DCs (cDCs). In line with the key role of CCL22 to facilitate DC-Treg cell interaction, RelB-deficient DCs have a selective advantage to interact with Treg cells in an antigen-specific manner. In addition, DC-specific RelB knockout animals show increased total Foxp3+ Treg cell numbers irrespective of inflammatory status. Consequently, DC-specific RelB knockout animals fail to mount protective Th2-dominated immune responses in the intestine after infection with Heligmosomoides polygyrus bakeri. Thus, RelB expression in cDCs acts as a rheostat to establish a tolerogenic set point that is maintained even during strong type 2 immune conditions and thereby is a key regulator of intestinal homeostasis.