bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-perceived acceptability of a virtual world-based cardiac rehabilitation program
Authors: Brewer LaPrincess C , Kaihoi Brian , Schaepe Karen , Zarling Kathleen , Squires Ray W , Thomas Randal J , Kopecky Stephen 
Published: April 2017

Background Despite its benefits, cardiac rehabilitation (CR) participation rates remain subpar. Telehealth lifestyle interventions have emerged as modalities to enhance CR accessibility. Virtual-world (VW) technology may provide a means to increase CR use. Objectives This pilot study assessed the feasibility and acceptability of a VW-based CR program as an extension to medical center-based CR. Our goal is to apply the study results toward the design of a patient-centered VW platform prototype with high usability, understandability, and credibility. Methods Patients ( n = 8, 25% women) recently enrolled in outpatient CR at Mayo Clinic, Rochester, Minnesota participated in a 12-week, VW health education program and provided feedback on the usability, design and satisfaction of the intervention at baseline and completion. A mixed-methods approach was used to analyze the participant perceptions of the intervention. Results Overall, there were positive participant perceptions of the VW experience. There was unanimous high satisfaction with the graphical interface appearance and ease of use. Participants placed value on the convenience, accessibility, and social connectivity of the remote program as well as the novelty of the simulation platform presentations, which aided in memorability of key concepts. Greater than 80% of participants reported that the program improved their health knowledge and helped to maintain better health habits. Conclusions Our pilot study revealed the feasibility and acceptability of an innovative VW-based CR program among cardiac patients. This novel delivery method for CR has the potential to influence healthy lifestyle change and to increase accessibility to vulnerable populations with higher cardiovascular disease burdens.
Seek, test, treat: substance-using women in the HIV treatment cascade in South Africa
Authors: Wechsberg Wendee M. , van der Horst Charles , Ndirangu Jacqueline , Doherty Irene A. , Kline Tracy , Browne Felicia A. , Belus Jennifer M. , Nance Robin , Zule William A. 
Published: April 2017

Abstract
Background
Women in South Africa who use alcohol and other drugs face multiple barriers to HIV care. These barriers make it difficult for women to progress through each step in the HIV treatment cascade from diagnosis to treatment initiation and adherence. This paper examines correlates of HIV status, newly diagnosed HIV status, and use of antiretroviral therapy (ART).

Methods
Outreach workers recruited sexually active Black African women who used substances in Pretoria as part of a U.S. National Institutes of Health-funded geographically clustered randomized trial examining the effect of an intervention to reduce alcohol and drug use as well as sexual risk behaviors. To address the question of interest in the current investigation, cross-sectional baseline data were used. At study enrollment, all participants (N = 641) completed an interview, and underwent rapid HIV testing and biological drug screening. Those who tested positive for HIV and were eligible for ART were asked about their barriers to initiating or adhering to ART. Bivariate and multivariable logistic regression analyses were conducted to determine correlates of HIV status, newly diagnosed HIV, and ART use.

Results
At enrollment, 55% of participants tested positive for HIV, and 36% of these women were newly diagnosed. In multivariable analyses of the entire sample, women who had completed 10th grade were less likely to be living with HIV (OR 0.69; CI 0.48, 0.99) and those from the inner city were more likely to be living with HIV (OR 1.83; CI 1.26, 2.67). Among HIV-positive participants, women were less likely to be newly diagnosed if they had ever been in substance abuse treatment (OR 0.15; CI 0.03, 0.69) or used a condom at last sex (OR 0.58; CI 0.34, 0.98) and more likely to be newly diagnosed if they were physically assaulted in the past year (OR 1.97; CI 1.01, 3.84). Among women eligible for ART, fewer were likely to be on treatment (by self-report) if they had a positive urine test for opiates or cocaine (OR 0.27; CI 0.09, 0.80).

Conclusions
These results, although cross-sectional, provide some guidance for provincial authorities to address barriers to HIV care for sexually active, substance-using vulnerable women in Pretoria. Targeting the inner city with prevention campaigns, expanding and improving substance abuse treatment programs, linking clients with simultaneous HIV testing and treatment, and targeting women who have experienced sexual assault and violence may help the government achieve the UNAIDS 90-90-90 treatment target.
Clinical Trials.gov NCT01497405 registered on December 1, 2011.
Randomized Phase III Trial of Trastuzumab Plus Capecitabine With or Without Pertuzumab in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Experienced Disease Progression During or After Trastuzumab-Based Therapy
Authors: Urruticoechea Ander , Rizwanullah Mohammed , Im Seock-Ah , Ruiz Antonio Carlos Sánchez , Láng István , Tomasello Gianluca , Douthwaite Hannah , Badovinac Crnjevic Tanja , Heeson Sarah , Eng-Wong Jennifer , Muñoz Montserrat 
Published: April 2017

Purpose To assess the efficacy and safety of trastuzumab plus capecitabine with or without pertuzumab in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer who experienced disease progression during or after trastuzumab-based therapy and received a prior taxane. Patients and Methods Patients were randomly assigned to arm A: trastuzumab 8 mg/kg → 6 mg/kg once every 3 weeks plus capecitabine 1,250 mg/m2 twice a day (2 weeks on, 1 week off, every 3 weeks); or arm B: pertuzumab 840 mg → 420 mg once every 3 weeks plus trastuzumab at the same dose and schedule as arm A plus capecitabine 1,000 mg/m2 on the same schedule as arm A. The primary end point was independent review facility–assessed progression-free survival (IRF PFS). Secondary end points included overall survival (OS) and safety. Hierarchical testing procedures were used to control type I error for statistical testing of IRF PFS, OS, and objective response rate. Results Randomly assigned (intent-to-treat) populations were 224 and 228 patients in arms A and B, respectively. Median IRF PFS at 28.6 and 25.3 months’ median follow-up was 9.0 v 11.1 months (hazard ratio, 0.82; 95% CI, 0.65 to 1.02; P = .0731) and interim OS was 28.1 v 36.1 months (hazard ratio, 0.68; 95% CI, 0.51 to 0.90). The most common adverse events (all grades; incidence of ≥ 10% in either arm and ≥ 5% difference between arms) were hand-foot syndrome, nausea, and neutropenia in arm A, and diarrhea, rash, and nasopharyngitis in arm B. Conclusion The addition of pertuzumab to trastuzumab and capecitabine did not significantly improve IRF PFS. An 8-month increase in median OS to 36.1 months with pertuzumab was observed. Statistical significance for OS cannot be claimed because of the hierarchical testing of OS after the primary PFS end point; however, the magnitude of OS difference is in keeping with prior experience of pertuzumab in metastatic breast cancer. No new safety signals were identified.
COMPASS: Continuous Open Mouse Phenotyping of Activity and Sleep Status
Authors: Brown Laurence A. , Hasan Sibah , Foster Russell G. , Peirson Stuart N. 
Published: April 2017

Background: Disruption of rhythms in activity and rest occur in many diseases, and provide an important indicator of healthy physiology and behaviour. However, outside the field of sleep and circadian rhythm research, these rhythmic processes are rarely measured due to the requirement for specialised resources and expertise. Until recently, the primary approach to measuring activity in laboratory rodents has been based on voluntary running wheel activity. By contrast, measuring sleep requires the use of electroencephalography (EEG), which involves invasive surgical procedures and time-consuming data analysis. Methods: Here we describe a simple, non-invasive system to measure home cage activity in mice based upon passive infrared (PIR) motion sensors. Careful calibration of this system will allow users to simultaneously assess sleep status in mice. The use of open-source tools and simple sensors keeps the cost and the size of data-files down, in order to increase ease of use and uptake. Results: In addition to providing accurate data on circadian activity parameters, here we show that extended immobility of >40 seconds provides a reliable indicator of sleep, correlating well with EEG-defined sleep (Pearson’s r >0.95, 4 mice). Conclusions: Whilst any detailed analysis of sleep patterns in mice will require EEG, behaviourally-defined sleep provides a valuable non-invasive means of simultaneously phenotyping both circadian rhythms and sleep. Whilst previous approaches have relied upon analysis of video data, here we show that simple motion sensors provide a cheap and effective alternative, enabling real-time analysis and longitudinal studies extending over weeks or even months. The data files produced are small, enabling easy deposition and sharing. We have named this system COMPASS - Continuous Open Mouse Phenotyping of Activity and Sleep Status. This simple approach is of particular value in phenotyping screens as well as providing an ideal tool to assess activity and rest cycles for non-specialists.
Information Technology, Revenues, and Profits: Exploring the Role of Foreign and Domestic Operations
Authors: Mithas Sunil , Whitaker Jonathan , Tafti Ali 
Published: April 2017

How does information technology (IT) enable firms to globalize their operations and achieve higher foreign profits? We use archival data for multinational firms publicly traded in the United States for the years 1999–2006, and find indirect evidence for the role of IT to help firms achieve higher foreign profits through revenue growth rather than cost reduction. Our findings suggest that foreign responsiveness plays a more important role in generating foreign profits than does value chain structure. Our exploratory analyses for the effect of IT on domestic revenues and profits suggest some evidence for equalization of returns across foreign and domestic operations. Among additional results, we find that research and development is positively associated with foreign revenues and foreign profits with an effect greater than that of IT, and advertising is positively associated with foreign revenues with an effect greater than that of IT. By documenting how IT creates value for firms through globalization, we extend the business value of IT and international business literatures that have so far touched on firm-level globalization benefits from IT only in passing. The findings can help managers decide how to allocate discretionary expenditures to achieve strategic objectives such as foreign and domestic revenues and profits, and the role of revenue versus cost mechanisms. The online appendix is available at https://doi.org/10.1287/isre.2017.0689 .
Disparities in Diagnosis and Treatment of Autism in Latino and Non-Latino White Families
Authors: Zuckerman Katharine E. , Lindly Olivia J. , Reyes Nuri M. , Chavez Alison E. , Macias Kristy , Smith Kathryn N. , Reynolds Ann 
Published: April 2017

OBJECTIVES:
To compare barriers to autism spectrum disorder (ASD) diagnosis and current ASD-related service use among non-Latino white (NLW) families and Latino families with English proficiency (L-EP) or limited English proficiency (L-LEP).

METHODS:
We conducted a mixed-mode survey of families of children with confirmed ASD seen at specialty clinics in 3 United States cities. Bivariate and multivariate analyses compared barriers to ASD diagnosis, current service use, and unmet therapy need among NLW, L-EP, and L-LEP families.

RESULTS:
Overall, barriers to ASD diagnosis were prevalent: families (n = 352) experienced a mean of 8 of 15 barriers to ASD diagnosis. The most prevalent barriers overall were “stress of diagnostic process,” “parent knowledge about ASD,” and “understanding medical system.” Compared with NLW families, L-LEP families were more likely to experience barriers related to knowledge about ASD and trust in providers. Children in L-LEP families also had fewer current therapy hours and more unmet therapy needs than children in NLW families. L-EP families’ barriers and treatment services use profile was more similar to NLW than to L-LEP families.

CONCLUSIONS:
English proficiency was an important marker for barriers to ASD diagnosis and treatment in Latinos. Increasing ASD-related knowledge and provider trust may decrease disparities in the diagnosis and treatment of ASD among US Latinos.
Országos Táplálkozás és Tápláltsági Állapot Vizsgálat – OTÁP2014. III. A magyar lakosság makroelem-bevitele
Authors: Nagy Barbara , Nagy-Lőrincz Zsuzsanna , Bakacs Márta , Illés Éva , Sarkadi Nagy Eszter , Martos Éva 
Published: April 2017

Abstract: Introduction and aim: The Hungarian Diet and Nutritional Status Survey examined the dietary habits of the Hungarian adult population. The aim of the study is to present the macroelement intake of the population. Method: The study represents the macrolement intake of the population with age 18 or over on the day of 31 December 2013, of those who are non-institutionalised. Results: Salt intake decreased compared to the findings of the previous study in 2009 but it is still extremely high (15.9 g in men and 11.2 g in women). The potassium intake is below the recommendation, which together with a high sodium intake increases the risk of high blood pressure. Calcium intake in the youngest age group reached the recommendations, whereas the intake in the oldest age group was well below the references. Magnesium intake complied with the recommendation, the intake of phosphorus however exceeded it. High sodium intake still represents substantial public health risk. Conclusion: The reduction that occured in the population’s salt intake since 2009 demonstrates the effectiveness of implemented prevention programs, cooperation with the industry and public awareness campaigns. Orv Hetil. 2017; 158(17): 653–661.
Reading Accuracy in EFL Students with a Transparent L1 Background – a Case Study from Poland
Authors: Łodej Monika 
Published: April 2017

Research indicates that L2 reading competence is influenced by L1 reading ability, L2 proficiency, and L2 decoding competence. The present study investigates the significance of two variables, regularity and frequency, in relation to English as a Foreign Language (EFL) reading accuracy in students with a transparent L1. Fifteen 6th grade students in their sixth year of regular instruction in English took part in this study. Their mother tongue is Polish whereas English is their foreign language; thus, their language competence in L1 and L2 differs substantially. The research design followed Glusko (1979), Plaut (1996), and Wang and Koda (2007). There are four sets of real words. Two features of real words are manipulated for regularity and frequency. The study reveals that both conditions of script, regularity and transparency, affect reading accuracy in EFL students. However, the dimension of regularity is a stronger predicator of accuracy than the frequency with which the students encounter a word. From the pedagogical perspective, the collected data supports the use of structured reading instructions in the EFL classroom in order to restrain negative transfer of L1 to L2 reading strategies.
Efficacy of kinesio taping in reducing low back pain
Authors: Trobec Kim , Peršolja Melita 
Published: April 2017

Introduction: Kinesio taping is rehabilitative technique used to facilitate the body’s natural healing process while providing support and stability to muscles and joints, without restricting their range of motion. We conducted a thorough literature search and evaluation to clarify whether kinesio taping is effective in reducing lower back pain.
Methods: Cochrane Library, CINAHL, COBIB.SI, PubMed and Science Direct were searched using Boolean operators search strings of different keywords such as: adult, low back pain, Kinesio tape, Kinesio taping, kinesiotaping, effects. The search was limited to full-text articles published from 2011 to 2016.
Results: A total of 137 records were identified, 123 abstracts screened, and 14 full-text articles assessed for eligibility. Finally, nine publications were selected using CASP tool: eight randomized clinical studies and one literature review. The key variables from collected data were the subject characteristics, taping technique, control interventions, instrument, and outcome.
Conclusions: The effect of Kinesio taping in reducing low back pain is positive, but was not statistically significant in analyzed studies. Taping therapy may therefore be used as a supplementary method to conventional physical therapy procedures, and may be important for patients because of its easy accessibility and safet
La Organización Internacional del Trabajo y el problema social indígena: La encuesta en Perú de 1936.
Authors: Yáñez Andrade Juan Carlos 
Published: April 2017

<p align="right"><strong><br /></strong></p><p align="right"><strong> </strong></p><p><strong>Resumen</strong></p><p>Este artículo aborda la encuesta realizada en Perú en 1936 por la Organización Internacional del Trabajo con el fin de conocer el problema social indígena. A partir de las resoluciones de la Conferencia Interamericana del Trabajo de 1936 y el informe elaborado por Moisés Poblete Troncoso se muestra la importancia que tienen los nuevos problemas sociales en las instancias de cooperación técnica del periodo. La encuesta de Moisés Poblete no solo ayudará a conocer mejor la realidad indígena peruana, sino que también servirá de insumo para las acciones futuras de la Organización Internacional del Trabajo en la materia, proceso que finalizará, en una primera etapa, con la convención 107 de 1952. </p><p> </p><p><em> </em></p><p align="center"><strong>The International Labour Organization and the Indigenous social problem:</strong></p><p align="center"><strong>The survey in Peru of 1936</strong></p><p><em> </em></p><p><strong>Abstract</strong></p><p>This article studies the survey realized in Peru in 1936 by the International Labour Organization in order to know the Indigenous social problem. From the resolutions of the Inter-American Conference of Labour of 1936 and the report elaborated by Moisés Poblete Troncoso there appears the importance of new social problems in the technical cooperation. The Moises Poblete survey not only will help to know better the Indigenous Peruvian reality, but also it will use as input for the future actions of the International Labour Organization in the matter, process that will finish, in the first stage, with the convention 107 of 1952.</p><p align="right"><strong><br /></strong></p>
Las entidades de la frontera norte y la Agenda 2030: retos para una gobernanza para el desarrollo
Authors: Ramos Garcia Jose Maria 
Published: April 2017

<p>El objetivo de este artículo es analizar el papel de la cooperación internacional y transfronteriza de los gobiernos locales del norte de México para atender los Objetivos de Desarrollo Sustentables de la Agenda 2030, según sus capacidades institucionales y acorde a los antecedentes de la Agenda 21 y de los Objetivos del Desarrollo Milenio (ODM) (2015)</p><p> </p><p><br /><br /></p>
Market and Policy in Argentina: Exploring the Non- Market Strategies and Government in A Hybrid Regime
Authors: Simone Paola De 
Published: April 2017

<p>This paper investigates the nature of non-market strategies in the case of expanding business in Argentinian. Result of the enquiry presents a new conceptual framework that allow us to understand the Argentine reality in a proper manner. The full investigation suggests that in other countries the non-market strategies are being studied, without establishing a discipline. Academic material and specific courses have been developed in the business schools of the universities, but, except in specific and small cases, there is no research field and cases developed in Argentina. The expanded research hypothesis argues that companies in Argentina do not understand how to approach the political decisions of the State of hybrid political regimes in matters that concern them. Companies focus on market logic without understanding the logic of "non-market" environments. </p>
A PRIMEIRIDADE E INFINITO NA GRÉCIA ANTIGA E NA AMAZÔNIA
Authors: Silva Adelio Alves da 
Published: April 2017

Apresenta a experiência de Primeiridade e ‘Infinito’, como um princípio universal e atemporal. Na história do pensamento, ela surge nos poemas concebidos por Homero (IIíada e Odisseia), sua ocorrência acontece em qualquer lugar, sem mudar a sua forma, não importa o período histórico. Essa mesma experiência ocorreu quando o poeta Lauro esteve pela primeira vez na Amazônia. Nela ele identificou as mesmas manifestações das experiências, do pastor, do marinheiro e do vigia que compõem os poemas de Homero. Cada representante da cultura da Grécia antiga foi substituído no mesmo poema por um representante da cultura amazônica (índio, barqueiro e ribeirinho) sem alterar a sua estrutura. Como condição de unidade do poema.
Creating Inclusive EAL Classrooms: How Language Instruction for Newcomers to Canada (LINC) Instructors Understand and Mitigate Barriers for Students Who Have Experienced Trauma
Authors: Wilbur Amea 
Published: April 2017

This article draws on my dissertation, “Creating Inclusive EAL Classrooms: How LINC Instructors Understand and Mitigate Barriers for Students Who Have Experienced Trauma.” The article explores some assumptions and understandings that English as an Additional Language (EAL) teachers bring to teaching students believed to have experienced trauma, and illustrates the dilemmas they face in supporting such students in a government-funded and designed EAL program for newcomers. Using the concept of Iris Marion Young’s “Five Faces of Oppression” (1990), the data and ndings of the research for my dissertation are explored, contributing to the discussion on trauma and learning in EAL programs and specifically in relation to adult immigrants and refugees. Cet article puise dans ma thèse « Creating Inclusive EAL Classrooms: How LINC Instructors Understand and Mitigate Barriers for Students Who Have Experienced Trauma ». L’article explore quelques hypothèses et interprétations que véhiculent les enseignants d’anglais comme langue additionnelle (ALA) à l’égard d’élèves qui ont subi des traumatismes d’une part, et il illustre les dilemmes auxquels font face les enseignants en appuyant ces élèves dans le cadre d’un programme d’ALA pour nouveaux arrivants et qui est nancé et conçu par le gouvernement d’autre part. M’appuyant sur le concept des cinq visages de l’oppression de Iris Marion Young (« Five Faces of Oppression », 1990), je me penche sur les données et les résultats de ma thèse, contribuant ainsi à la discussion sur le traumatisme et l’apprentissage dans les programmes d’ALA, notamment en ce qui concerne les immigrants et les réfugiés adultes.