bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Centrosome Fracturing during Cell Navigation
Authors: Schmitt Madeleine T. , Ruiz-Fernandez Mauricio J.A. , Stefanowski Kasia , Kroll Janina , Hauschild Robert , Merrin Jack , Penz Thomas , Kiermaier Eva , Bock Christoph , Straub Tobias , Renkawitz Jörg 
Published: October 2024

AbstractThe centrosome is the primary microtubule orchestrator in most eukaryotic cells, nucleating and anchoring microtubules that grow radially and exert forces on cargos. At the same time, mechanical stresses from the microenvironment and cellular shape changes compress and bend microtubules. Yet, centrosomes are membrane-less organelles, raising the question of how centrosomes withstand mechanical forces. Here we discover that centrosomes in non-dividing cells can mechanically fracture. We reveal that centrosomes experience mechanical deformations during microenvironmental confinement and navigational pathfinding by motile cells. Coherence of the centrosome is maintained by Dyrk3, preventing fracturing by mechanical forces. Centrosome fracturing impedes cellular function by generating coexisting microtubule organizing centers that compete during path navigation and thereby cause cellular entanglement in the microenvironment. Our findings show that non-dividing cells actively maintain the integrity of the centrosome to withstand mechanical forces. Given that almost all cells in multicellular organism experience forces, these results suggest that centrosome stability preservation is fundamental during development, tissue maintenance, immunology, and disease.One-Sentence SummaryPathfinding during cellular motility causes centrosome breakage counteracted by Dyrk3 activity.
Elevating excellence: a standardized process of training and development for private sector educational SMEs
Authors: Elahi Fazal , Bilal Ahmad Raza 
Published: October 2024

PurposeThe study aims to address the critical area of training and development within private educational small and medium-sized enterprises (SMEs) in Pakistan. It seeks to develop and standardize training and development process in private sector educational SMEs and establish a structured approach to training with the purpose of unlocking the full potential of the workforce, advancing educators’ professional growth and propelling organizational progress.Design/methodology/approachThis study employs a meticulous three-phase approach. It begins with insightful interviews with school principals to investigate existing training practices. The subsequent phase involves formulating a comprehensive training and development policy, outlining purpose, scope, responsibilities, procedures and budget allocation. This policy undergoes participatory refinement to cater to specific SME needs. In the third phase, experimental design was adopted. Two groups, the experiment group and the control group, were formulated to check the effectiveness of proposed processes.FindingsRigorous statistical analysis, employing paired sample t-tests, unequivocally demonstrates a significant elevation in mean scores post-implementation of standardized training and development process. These findings affirm the efficacy of the policy in enhancing the effectiveness of training and development activities in private sector educational SMEs.Practical implicationsThe research highlights profound implications. By establishing a structured approach to training and development, educational SMEs can not only advance educators’ professional growth but also propel organizational progress and enhance education quality. It will provide a structured and step-by-step process to boost the work quality of staff. The study emphasizes the need for consistent implementation.Originality/valueThis research marks a substantial stride in revolutionizing how human capital is cultivated in private sector educational SMEs. It positions them to exert a transformative impact on Pakistan’s educational landscape, furthering the journey toward excellence. The study suggests avenues for future research, including the adaptation of this model to diverse educational contexts and an assessment of its scalability.
Pizza Town Sukkur: sustaining in the current competitive environment
Authors: Memon Ubedullah , Lanjo Asghar Ali , Shaikh Javeria , Khan Mahnoor , Ali Masroor 
Published: October 2024

Learning outcomes
After reading this case students will be able to understand the role of General Environment analysis in strategic decision-making; to understand the use of different models such as Porter’s Five Forces, SWOT and resource-based view; and to enable graduates to apply different strategies such as business level and growth strategies and environmental analysis to any company or industry on their own.

Case overview/synopsis
Pizza Town Sukkur, once a popular spot for delicious pizzas, was facing a tough situation. New competition was threatening its success, and the manager, Mr. Faisal Gul, was torn between sticking to old ways or trying new ideas. A surprise invitation to a special industry summit added excitement but also uncertainty. The restaurant, started by Honey Bhai in 2007, used to be a hit, but now it struggled with challenges like not having online ordering and falling behind in marketing. Other pizza places in Sukkur, like Pizza Mart, Pizza King and Pizza Grill, were giving tough competition. The story unfolded in the lively setting of Sukkur's food scene, with Pizza Town at a crossroads – whether to embrace change and technology or risk fading away in the face of new rivals.

Complexity academic level
Undergraduate and Graduate

Supplementary material
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
Does integrated reporting offer firms more legitimacy?
Authors: Bansal Manish 
Published: October 2024

PurposeThe study delves into the impact of integrating reporting (IR) on three earnings management tools, namely classification shifting (CS), real-based earnings management (REM) and accrual-based earnings management (AEM) under the Indian institutional settings.Design/methodology/approachThe data analysis involved the application of panel data regression models. Our dataset comprises 2,244 firm-years listed on the Bombay Stock Exchange spanning over financial years from March 2015 to 2021. To address endogeneity and self-selection bias concerns, a propensity score matching technique has been employed.FindingsOur empirical results exhibit that IR-adopting firms are engaged in earnings management. Further, we find that IR-adopting firms have reduced their engagement in AEM and REM, however, their CS practices have been increased, indicating the substitution relationship between earnings management tools after the adoption of IR. It implies that firms shift their preference from more to less observable earnings management tools after the adoption of the IR, which aligns with the idea that firms adopt IR to gain legitimacy, however, their intention to deceive stakeholders through earnings management remains unchanged. The inclination of firms toward CS can be ascribed to its cost-effectiveness, as it leaves net profit unchanged, hence less likelihood of being detected by auditors. Overall, our results align with the principle of legitimacy theory.Research limitations/implicationsThe study focuses exclusively on three primary forms of accounting manipulation and assesses IR holistically, rather than investigating the influence of each capital individually within IR.Practical implicationsWith a shift towards less detectable methods like CS, auditors must adapt their scrutiny and be mindful of their clients' IR adoption. Investors should scrutinize IR-adopting firms' financial disclosures, especially line items, as CS does not impact the net profits.Originality/valueIt is the pioneering research to thoroughly explore the impact of IR on different earnings management tools and strengthen the conceptual frameworks of legitimacy theory by documenting that firms adopt IR to gain legitimacy, however their intention to engage in earnings management remains intact.
Green knowledge management: a bibliometric analysis, research trends and future directions
Authors: Ulhaq Irfan , Nayak Rajkishore , George Majo , Nguyen Hung , Quang Huy 
Published: October 2024

Purpose
Green knowledge management (GKM) has become a critical factor for modern organizations, offering a multifaceted approach to enhancing business operations while promoting environmental sustainability. The purpose of this paper is to review the literature and explore how GKM helps companies reduce their ecological footprint by digitalizing processes and minimizing physical storage needs, thus aligning with growing expectations for corporate environmental responsibility. The necessity for conducting a GKM review is underscored by the increasing recognition of sustainability, environmental performance and as a critical component of organizational corporate success in the contemporary business landscape.

Design/methodology/approach
This study conducted a bibliometric analysis of 994 papers related to GKM from 2005 until August 2024.

Findings
Over the 20 years of research on GKM, this bibliometric analysis drew the interlinked relationships between main theme of KM in the context of sustainable practices, processes, social and related theories. This study identifies green innovation, digital transformation, green and lean supply chains, leadership and technology tools. Future research can explore themes such as green and lean processes, barriers and enablers, role of leadership and ambidexterity in green supply chain integration using different theoretical lenses.

Research limitations/implications
Although the findings of this study are important to GKM research, there are a number of limitations to this investigation. The research database used exclusively was the Web of Science and Scopus, which contained the indexed papers. Future investigations may draw from various databases, such as EBSCO and Google Scholar. Additionally, the use of topic modelling and other artificial intelligence frameworks could enhance research analysis. Subsequently, research papers may expand their scope to encompass conference papers, books and book chapters, in addition to articles.

Practical implications
This review gives a holistic understanding of GKM practices across various sectors which not only enhances organizational performance but also contributes to broader environmental goals. This study offers an understanding on GKM on holistic approach that combines total quality management (TQM), absorptive capacity and collaborative frameworks to foster innovation and sustainability.

Originality/value
It is evident from the review that research in GKM is evolving gaining momentum. This review provides a comprehensive understanding of the GKM literature, from its earliest forms of basic concepts aligned with the sustainability and progressing more into the concepts of GKM adoption for green innovation by highlighting multiple theories, factors and gaps in the studies.
Breaking free from linear assumptions: Unravelling the relationship between affective polarization and democratic support
Authors: JANSSEN LISA , TURKENBURG EMMA 
Published: October 2024

AbstractScholars increasingly raise concerns about the alleged detrimental impact of affective polarization on citizens’ democratic attitudes. Yet, prior studies on the relationship between affective polarization and democratic support have yielded mixed results: Whereas some scholars report evidence that affective polarization erodes citizens’ support for democracy, others report null findings. In this research note, we posit that one relevant explanation for these mixed results is that the relationship between affective polarization and democratic support is not linear, but rather negatively curvilinear (i.e., an inverted U‐shape). Though extreme levels of affective polarization may harm citizens’ democratic commitments, a moderate amount of affective polarization can strengthen democratic support by heightening the political stakes and stimulating democratic involvement. Employing generalized additive modelling on data from the CNEP collected in Germany, the United Kingdom, and the United States, we show strong and robust support for this negatively curvilinear pattern. These findings have important implications for our understanding of the dynamics between affective polarization and democratic support, as well as for the recommended estimation strategies of future studies that aim to explore this relationship.
Anatomical and functional outcomes of rectal prolapse treatment with laparoscopic pelvic organ prolapse suspension versus laparoscopic ventral mesh rectopexy
Authors: Zeinalpour Adel , Bananzadeh Alimohammad , Safarpour Mohammad Mostafa , Shojaei‐Zarghani Sara , Shahidinia Seyede Saeideh , Hosseini Seyed Vahid , Safarpour Ali Reza 
Published: October 2024

AbstractAimVery few studies have compared laparoscopic pelvic organ prolapse suspension (POPS) and laparoscopic ventral mesh rectopexy (LVMR) in the treatment of rectal prolapse, particularly regarding the comparison of improvement rates in obstructed defecation syndrome (ODS). This study aimed to compare the anatomical and functional outcomes of these two methods over a long‐term follow‐up period.Patients and methodsThis retrospective study was conducted on 120 female patients diagnosed with rectal prolapse who underwent surgery at the Colorectal Surgery Department of Shahid Faqihi Hospital in Shiraz, Iran, between October 2015 and October 2022. The patients were categorised into two groups based on their surgical procedures: 58 underwent LVMR in the first group, and 62 underwent POPS in the second group.ResultsRecurrence of prolapse occurred in 7 (12.1%) patients in the LVMR group and 5 (8.1%) patients in the POPS group (P = .550). The mean operation time, mean length of hospital stay, Visual Analogue Scale score, early and late post‐operative complications, Cleveland Clinic Incontinence Score, ODS symptoms, and Wexner Constipation Scores did not differ significantly between the two groups.ConclusionBoth laparoscopic POPS and LVMR techniques significantly improved the anatomical and functional outcomes in the treatment of rectal prolapse and obstructed defecation. LVMR and POPS can each be considered first‐line treatment options for rectal prolapse, depending on the specific case.
An integrative strategy used by the aphid Uroleucon formosanum to counter host sesquiterpene lactone defense: Insights from combined genomic and transcriptomic analysis
Authors: Li Jing‐Bo , Jiang Li‐Yun , Qiao Ge‐Xia , Chen Jing 
Published: October 2024

AbstractInsect herbivores adapt and develop strategies to counteract plant chemical defenses. The aphid Uroleucon formosanum is a serious sap‐sucking pest that infests lettuces containing toxic sesquiterpene lactones (STLs). Herein, we employed a combination of genome sequencing and RNA‐seq transcriptome profiling to understand the mechanisms underlying phytotoxin tolerance in U. formosanum. We generated the first chromosome‐level genome assembly for U. formosanum, with a total size of 453.26 Mb and a scaffold N50 of 33.22 Mb. Comparative genomic analyses revealed an enrichment of signals for positive selection and gene family expansion in immune‐related pathways. Specifically, the expanded set of heat shock protein 70 (HSP70) genes showed upregulation after treatment with lactucin, suggesting that they may play a role in the immune response against STLs. The expression of takeout‐like genes and cuticle‐associated genes was also significantly increased in the lactucin‐treated samples. Additionally, 53 cytochrome P450 monooxygenase, 30 carboxylesterase, 19 glutathione S‐transferase, 32 uridine diphosphate glycosyltransferase and 63 ATP‐binding cassette (ABC) transporter genes were identified in the U. formosanum genome. CYP4C1, CYP6A13 and 7 ABC genes were strongly upregulated in response to lactucin treatment, indicating the involvement of detoxifying enzymes in the tolerance of U. formosanum to STLs. Our findings suggest that the cuticle barrier, immune response and enzyme‐mediated metabolic detoxification jointly enhance the tolerance of U. formosanum to phytotoxins and promote its adaptation to host plants. This study presents a valuable genomic resource and provides insights into insect adaptation to plant chemical challenges and future technological developments for pest management.
Suicide methods and severe mental illness: A systematic review and meta‐analysis
Authors: Trott M. , Suetani S. , Arnautovska U. , Kisely S. , Kar Ray M. , Theodoros T. , Le V. , Leske S. , Lu M. , Soole R. , Warren N. , Siskind D. 
Published: October 2024

AbstractIntroductionPeople with severe mental illness (SMI) have a higher risk of suicide compared with the general population. However, variations in suicide methods between people with different SMIs have not been examined. The aim of this pre‐registered (PROSPERO CRD42022351748) systematic review was to pool the odds of people with SMI who die by suicide versus those with no SMI, stratified by suicide method.MethodsSearches were conducted on December 11, 2023 across PubMed, PsycInfo, CINAHL, and Embase. Eligible studies were those that reported suicide deaths stratified by SMI and suicide methods. Studies were pooled in a random‐effects meta‐analysis, and risk of bias was measured by the Joanna Briggs Institute checklist.ResultsAfter screening, 12 studies were eligible (n = 380,523). Compared with those with no SMI, people with schizophrenia had 3.38× higher odds of jumping from heights (95% CI: 2.08–5.50), 1.93× higher odds of drowning (95% CI: 1.50–2.48). People with bipolar disorder also had 3.2× higher odds of jumping from heights (95% CI: 2.70–3.78). Finally, people with major depression had 3.11× higher odds of drug overdose (95% CI: 1.53–6.31), 2.11× higher odds of jumping from heights (95% CI: 1.93–2.31), and 2.33× lower odds of dying by firearms (OR = 0.43, 95% CI: 0.33–0.56). No studies were classified as high risk of bias, and no outcomes had high levels of imprecision or indirectness.ConclusionThese findings could inform lethal means counselling practices in this population. Additionally individual, clinical, community and public health interventions for people with SMI should prioritise, where feasible, means restriction including access to heights or drugs to overdose.
Standard v mini percutaneous nephrolithotomy in the supine modified lithotomy position: a randomized pilot study on 10–25 mm stones
Authors: McCahy Philip , Dat Anthony , Gilbourd Daniel , Paul Eldho , Shahbaz Shekib 
Published: October 2024

AbstractBackgroundPercutaneous nephrolithotomy (PCNL) is the recommended treatment for stones >2 cm in size. The majority of PCNL are still conducted with larger telescopes using tracts up to 30F in size. We have conducted a randomized pilot study comparing mini PCNL with our standard 22F PCNL for renal stones between 10 and 25 mm in diameter.MethodsPatients were randomized to either PCNL (24F Amplatz sheath/22F nephrosocope) or mini PCNL (18F Amplatz sheath/11F nephroscope). All operations were performed in the modified supine position. Patients were reviewed with imaging to assess stone clearance and complications.ResultsEighteen well matched patients were randomized. All procedures were completed as planned and all were tubeless with no complications. There were no differences in operative time, analgesia requirements or length of stay. Seven of nine (77.75%) standard PCNL were completely stone free at CT review with a 2 mm and a 5 mm fragments in the other patients. Four (44.4%) of the mini PCNL group were stone free, with stone fragments 4–10 mm remaining in the others. 40 patients/arm would be required for an adequately powered study.ConclusionThere was no advantage in using mini PCNL compared to our standard 24F PCNL in this pilot study. There may be benefits in using mini PCNL compared to the more widely used 30F PCNL and it may be a more cost‐effective alternative to laser pyeloscopic stone procedures.
Maternal and Neonatal Consequences of Early Augmentation of Labor Among Women With Spontaneous Onset of Labor: A National Population‐Based Study
Authors: Girault Aude , Blondel Béatrice , Fraser William , Goffinet François , Le Ray Camille 
Published: October 2024

ABSTRACTBackgroundWhile some labor interventions are essential in preventing maternal and neonatal morbidity, there is little evidence to support systematic early augmentation of labor (EAL). Our objective was to assess the association between EAL and cesarean delivery rate, postpartum hemorrhage and adverse neonatal outcomes.MethodsPopulation‐based study using data from the 2016 French Perinatal Survey. Women with a singleton cephalic fetus, delivering at term after a spontaneous labor were included. “EAL” was defined by artificial rupture of the membranes (AROM) and/or oxytocin within 1 h of admission and/or duration between interventions of less than 1 h. Women without EAL were women without labor augmentation or without EAL. The primary endpoint, cesarean delivery and the secondary endpoints were compared between women with and without EAL using univariate analysis. A multivariable logistic regression was adjusted on the suspected confounders and a propensity score approach was then performed.ResultsAmong the 7196 women included, 1524 (21.2%) had EAL. Cesarean delivery rates were significantly higher in the EAL group compared with the no EAL group, 8.40% versus 6.15% (p < 0.01). EAL was associated with cesarean delivery in the multivariable analysis aOR 1.45 95% CI [1.15–1.82] and in the cohort matched on the propensity score, OR 1.56 [1.17–2.07]. EAL was not associated with severe postpartum hemorrhage, low 5‐min Apgar score, low neonatal cord pH or transfer to NICU.ConclusionEAL is frequent, involving one in five spontaneous laboring women in France. This practice is associated with an increased cesarean delivery risk.
When do people switch queues? An empirical study of discretionary queue switching at a physical examination center
Authors: Li Yi‐Na , Cui Zhijian , Ji Junkai , Wei Jiuchang 
Published: October 2024

AbstractAutomatic queueing systems have been applied in many practical settings to guide customers through a sequence of service stages and achieve efficient queueing. However, our field observations of queueing from a large‐scale physical examination center, which adopts an automatic assignment system with the option of discretionary switching, reveal a relatively high likelihood of queue‐switching requests. That is, many queuers request overriding the algorithm's sequence and ask for a different one, leading to increased total waiting times. Motivated by these observations, this study investigates the behavioral mechanisms behind driving queuers’ switching decisions. Specifically, we examine the roles of two competing mechanisms as the waiting progresses: the motivation to explore a better opportunity (to reduce waiting time) and the consumption of cognitive resources for self‐control to adhere to the assigned queue. Our empirical results reveal a U‐shaped relationship between the examinees’ tendency to switch and the service progress. This U‐shaped relationship steepens when more (vs. less) queuers are ahead of the focal examinee and when the time is (vs. is not) “on an hour” (e.g., 9:00 and 10:00). This study contributes to the behavioral theory of queueing systems through a novel perspective highlighting the competing mechanisms driving individuals’ algorithm aversion behavior (i.e., queue switching) during the progress of multiple services, providing insights into how to design efficient queueing systems.