bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global, regional, and national temporal trends in mortality and disability-adjusted life years for cardiovascular disease attributable to low temperature during 1990–2019: an age-period-cohort analysis of the global burden of disease 2019 study
Authors: Li Xiaofei , Liu Zeye , Xie Jing , Shao Hua , Xia Ruibing , Li Yakun , Liu Yun , Fan Xiaohan 
Published: October 2024

BackgroundFew studies have focused on the region-specific relationship between cardiovascular disease (CVD) and low temperature worldwide.ObjectiveWe aimed to provide an overview of trends in mortality and disability-adjusted life years (DALYs) for CVD and its subtypes attributable to low temperature over the past 30 years in 204 countries and regions, along with the associations of these trends with age, period, and birth cohorts.MethodsData on the estimated burden of CVDs (including ischemic heart disease, hypertensive heart disease, and stroke) attributable to low temperature were obtained from the Global Burden of Disease Study 2019. We utilized an age-period-cohort model to estimate overall annual percentage changes in mortality (net drifts), annual percentage changes from 15 ~ 19 to 81 ~ 85 years (local drifts), and period and cohort relative risk (period/cohort effects) between 1990 and 2019.ResultsAmong noncommunicable diseases, CVDs had the highest mortality rate and DALY loss attributable to low temperature worldwide and has increased from 65.7 to 67.3%, which is mainly attributed to the increase in East Asia and Pacific region. In terms of the level of economic and social development, an inverted U-shape was found in the age-standardized mortality rates (ASMR) due to low-temperature across different sociodemographic indices (SDI) regions. Both high CVD mortality (19.45, 95% CI [14.54, 24.17%]) and a decreasing mortality rate related to low temperature (from 1990 to 2019, net drift, −3.25% [−3.76, 2.73%] per year) was found in high SDI countries or territories, with opposite outcome found in low SDIs regions. The older adults (70+) and men share the highest rate of CVD ASMR and DALY attributed to low temperature across all regions, especially in North America and Europe and Central Asia.ConclusionMortality and DALY loss from CVD attributable to low temperature showed an overall decreasing trend globally except for East Asia and Pacific region. SDI, sex, age and geographic location contributed to the diversity of the CVD disease burden associated with low temperature worldwide. More attention should be given to the older adults, men, and low SDI regions.
Prediction of pyramidal tract side effect threshold by intra-operative electromyography in subthalamic nucleus deep brain stimulation for patients with Parkinson's disease under general anaesthesia
Authors: Leung Lok Wa Laura , Lau Ka Yee Claire , Kan Kwok Yee Patricia , Ng Yikjin Amelia , Chan Man Chung Matthew , Ng Chi Ping Stephanie , Cheung Wing Lok , Hui Ka Ho Victor , Chan Yuen Chung David , Zhu Xian Lun , Chan Tat Ming Danny , Poon Wai Sang 
Published: October 2024

IntroductionIn DBS for patients with PD, STN is the most common DBS target with the sweet point located dorsal ipsilaterally adjacent to the pyramidal tract. During awake DBS lead implantation, macrostimulation is performed to test the clinical effects and side effects especially the pyramidal tract side effect (PTSE) threshold. A too low PTSE threshold will compromise the therapeutic stimulation window. When DBS lead implantation is performed under general anaesthesia (GA), there is a lack of real time feedback regarding the PTSE. In this study, we evaluated the macrostimulation-induced PTSE by electromyography (EMG) during DBS surgery under GA. Our aim is to investigate the prediction of post-operative programming PTSE threshold using EMG-based PTSE threshold, and its potential application to guide intra-operative lead implantation.Methods44 patients with advanced PD received STN DBS under GA were studied. Intra-operative macrostimulation via EMG was assessed from the contralateral upper limb. EMG signal activation was defined as the amplitude doubling or greater than the base line. In the first programming session at one month post-operation, the PTSE threshold was documented. All patients were followed up for one year to assess clinical outcome.ResultsAll 44 cases (88 sides) demonstrated activations of limb EMG via increasing amplitude of macrostimulation the contralateral STN under GA. Revision tracts were explored in 7 patients due to a low EMG activation threshold (&lt;= 2.5 mA). The mean intraoperative EMG-based PTSE threshold was 4.3 mA (SD 1.2 mA, Range 2.0–8.0 mA), programming PTSE threshold was 3.7 mA (SD 0.8 mA, Range 2.0–6.5 mA). Linear regression showed that EMG-based PTSE threshold was a statistically significant predictor variable for the programming PTSE threshold (p value &lt;0.001). At one year, the mean improvement of UPDRS Part III score at medication-off/DBS-on was 54.0% (SD 12.7%) and the levodopa equivalent dose (LED) reduction was 59.5% (SD 23.5%).ConclusionDuring STN DBS lead implantation under GA, PTSE threshold can be tested by EMG through macrostimulation. It can provide real-time information on the laterality of the trajectory and serves as reference to guide intra-operative DBS lead placement.
Evaluation of the comparative efficacy of green lipped mussel plus krill oil extracts (EAB-277), Biota orientalis extracts or NSAIDs for the treatment of dogs with osteoarthritis associated pain: a blinded, placebo-controlled study
Authors: Kampa Naruepon , Kaenkangploo Duangdaun , Jitpean Supranee , Srithunyarat Thanikul , Seesupa Suvaluk , Hoisang Somphong , Yongvanit Karn , Kamlangchai Phanthit , Tuchpramuk Pongsatorn , Lascelles B. Duncan X. 
Published: October 2024

IntroductionWith little to no regulation of the supplement markets and a paucity of quality information regarding clinical utility of individual marketed supplements, it is difficult for veterinarians to provide any evidence-based recommendations to owners. The current study aimed to provide clinically useful comparative efficacy data on certain marketed supplements.MethodsUsing a prospective, block-randomized, double-blinded, placebo-controlled design, one hundred and one pet dogs with clinical hip OA-associated pain with one side worse than the other (index limb) were randomly assigned to one of four treatment groups: Green lipped Mussel plus Krill oil extracts (Antinol® Rapid, EAB-277); Biota orientalis extracts (4CYTE™ Epiitalis® Forte); an NSAID (meloxicam); or placebo (sunflower oil). Peak vertical force (PVF, expressed as a percentage of bodyweight) of the index limb, orthopedic assessment score (OAS) and hematology and blood chemistry values were evaluated before treatment (week 0), at 2, 4 and 6 weeks during treatment.ResultsAt 6 weeks, the changes from baseline in PVF of the index limb in the EAB-277 and meloxicam groups were significantly greater than the change in the placebo and 4CYTE™ groups, and the placebo and 4CYTE groups were not different from each other. At 6 weeks, there were significant differences between the groups for overall OAS scores with the lowest scores (least impairment) in the EAB-277 and meloxicam groups, followed by the 4CYTE group and then the placebo group.DiscussionResults of this study indicate that meloxicam and EAB-277 have significant objectively measured benefits in managing OA-related pain in dogs compared to placebo, but 4CYTE does not differ from placebo.
A vantagem em ter um policial militar pedagogo nos cursos de formação da Polícia Militar do Paraná
Authors: Mello Ricardo Amaro de , Silva Segundo Cleverson Luiz Nascimento Antunes da , Silva Hinaldson Martins da , Souza Marilza Pereira de 
Published: October 2024

Objetivou-se neste estudo a importância do policial pedagogo no ambiente de aprendizado da Polícia Militar do Paraná, com ênfase aos cursos de formação, seja para Oficiais ou Praças. A pedagogia, por ser uma profissão ampla pode ser utilizada tanto na direção da escola como para lecionar as aulas, o que favorece todo o processo do ensino-aprendizagem, pois o pedagogo em seu curso, aprende sobre gestão, metodologias criativas, técnicas e ferramentas de ensino, o que proporciona aos discentes, a construção da aprendizagem, referente ao conteúdo proposto. A metodologia utilizada nesta pesquisa foi a qualitativa, buscando na leitura bibliográfica e documental as informações necessárias para a conclusão da ideia de acordo com o tema. Diante da revisão da literatura, verificou-se que a presença de um policial pedagogo nos cursos de formação facultará ao coordenador o direcionamento da função que o pedagogo poderá desempenhar, podendo fazer parte da coordenação ou docência, conforme suas habilidades e conhecimentos. Entendeu-se que a presença de um policial militar com entendimento sobre métodos e maneiras de ensinar, no grupo pedagógico, poderá transmitir aos docentes a necessidade da mudança da forma do ensino tradicional para práticas inovadoras significativas. Diante disso, o policial pedagogo poderá demonstrar aos demais colegas que possuem formação acadêmica em cursos cuja titulação seja em bacharelado, atualizações metodológicas de ensino, para que possam ministrar suas aulas com maior rendimento entre os alunos.
Catarata, a principal causa de cegueira reversível no mundo: o que todo médico necessita saber
Authors: Camacho Sebastián Alonso Hernández , Dias Pedro Soares , Oliveira Rafael Affonso de Rezende , Calicchio Robson José 
Published: October 2024

Introdução: A Catarata, cujo principal fator de risco é o progresso da idade, é a principal causa de cegueira no mundo, causando sobrecarga financeira aos serviços públicos e disfuncionalidade na vida das pessoas. Objetivo: Informar e esclarecer aos médicos clínicos generalistas a respeito da Catarata, discorrendo assim tópicos fundamentais da doença para a prática clínica. Metodologia: Revisão integrativa da literatura, realizada através das bases de dados do Pubmed, Scielo e Lilacs. Ao final do processo de seleção, com base nos descritores “Catarata”, “Cegueira”, “Saúde Ocular”, “Cataract Surgery”, “Epidemiologia”, foram incluídas 28 referências publicadas entre 2010 e 2024. Discussão: A Catarata consiste na opacificação total ou parcial do cristalino, o qual, inicialmente, é totalmente transparente. Com o passar da idade e a partir de outros fatores adjuvantes, inicia-se a opacificação das proteínas do epitélio. Diante das diversas manifestações iniciais, que culminam na diminuição da acuidade visual, o Ministério da Saúde preconiza o uso do teste da tabela de Snellen, em casos de suspeita de Catarata, para a derivação do paciente para um serviço oftalmológico especializado. Conclusão: Diante da relevância financeira e epidemiológica da Catarata, enfatizamos a importância da compreensão de profissionais de saúde sobre esta patologia cuja atuação precoce permite a diminuição de dependência para realizar atividades diária e manutenção da qualidade de vida.
Penerapan Algoritma Haar Cascade Clasifier dan Computer Neural Network Sebagai Presensi Karyawan
Authors: Doni Doni Karseno , Yuhandri  , Ramadhanu Agung 
Published: October 2024

Sistem pengenalan wajah merupakan program komputer yang secara otomatis dapat mendeteksi gambar digital atau video untuk mengidentifikasi atau mengautentikasi seseorang secara otomatis. Kesulitan dalam masalah pengenalan wajah sebagian besar disebabkan oleh kurangnya keberhasilan dalam menemukan fitur gambar tersebut. Pengenalan objek banyak digunakan oleh para pelaku industri untuk keperluan inspeksi, registrasi atau manipulasi. Penelitian ini bertujuan untuk menidentifikasi wajah pada masing – masing karyawan. Metode yang digunakan dalam penelitian ini adalah Haar Cascade Classifier (HCC) sebagai pendeteksi wajah dan metode Convolutional Neural Network (CNN) untuk proses identifikasi wajah. Proses pengenalan wajah ini dapat digunakan untuk mengidentifikasi masing – masing karyawan. Sehingga dalam melakukan presensi digital tidak ada kecurangan lagi yang dilakukan oleh karyawan. Dalam penelitian ini data yang diambil adalah data di Institut Teknologi dan Bisnis Indragiri. Algoritma Haar Cascade Classifier menjadi metode yang dapat digunakan dalam proses pengenalan polah wajah manusia. Sedangkan Convolutional Neural Network merupakan metode untuk mengidentifikasi serta mengklasifikasi hasil dari metode Haar Cascade Classifier sebagai tahap awal. Dalam hal pengklasifikasian image, metode Convolutional Neural Network merupakan metode yang dapat digunakan untuk pengklasifikasian wajah. Arsitektur Convolutional Neural Network yang digunakan dalam penelitian ini adalah alexnet. Dataset dari ImageNet lebih dari 14 juta gambar yang dikategrikan dalam ribuan kelas. Convolutional Neural Network memiliki arsitektur yang terinspirasi oleh struktur visual sistem manusia dan sangat efektif untuk tugas-tugas pengenalan gambar dan klasifikasi. Kesimpulan dari hasil penilitan ini yaitu dengan menggabungkan metode Haar Cascade Classifier dan Convolutional Neural Network dapat mempercepat proses pengenalan klasifikasi suatu objek wajah. Penelitian ini menggunakan kumpulan dataset wajah yang beragam, mencakup variasi sudut pandang, ekspresi, dan kondisi pencahayaan. Data yang digunakan terdiri dari seluruh karyawan yang memiliki 106 data wajah. Model CNN kemudian dilatih menggunakan data latih sebesar 85% dari keseluruhan data. Setelah model dilatih, selanjutnya dilakukan evaluasi model CNN melalui beberapa metrik evaluasi. Dari hasil evaluasi diperoleh tingkat akurasi yang baik sebesar 91% Hasil dari penelitian ini dapat digunakan untuk media presensi digital berbasis pengenalan wajah pada karyawan Institut Teknologi Dan Bisnis Indragiri.
PYDA—A Python Dashboard for Easy and Customizable Visualization and Fitting of Biophysical Data
Authors: Hebbelstrup Alexander S. , Teilum Kaare , Kragelund Birthe B. 
Published: October 2024

ABSTRACT
Research-integrating teaching offers a collective approach to engage students and researchers in real research questions, introducing them to authentic problem-solving strategies. In experimental research-integrating teaching, various different data are acquired and often analyzed by using specialized software programs. However, learning to operate these programs can sometimes divert attention from the research itself. To keep the focus on the research, we have developed a Python-based dashboard (PYDA) and implemented it successfully in a research-integrating course on intrinsically disordered proteins. PYDA simplifies data analysis by handling experimental data from techniques such as liquid chromatography, far-ultraviolet circular dichroism, and fluorescence spectroscopy in a unified way. Developed in Python by using the Plotly Dash framework and hosted on Heroku, PYDA allows students to visualize, convert, and analyze data without extensive prior knowledge of Python. By providing a streamlined, flexible, and customizable solution, PYDA enables students to focus on research and hypothesis development, fostering digitally competent and inquiry-driven problem solvers. PYDA is supplied with a set of example files that allows the user to test the program. These files can be accessed as the last item in the dropdown menu.
أثر علاقة الرجل بمطلقته الرجعية دراسة فقهية مقارنة بقانون الأحوال الشخصية الأردني
Authors: الحمود قاسم , العتوم نيبال 
Published: October 2024

هدفت الدراسة إلى معرفة أحكام علاقة الرجل بزوجته التي طلقها طلاقا رجعياً، وذلك في فترة العدة، وقد تم اتباع المنهج الاستقرائي والوصفي التحليلي المقارن في كتابة البحث، وتم بيان ماهية الطلاق في الاصطلاح وقانون الأحوال الشخصية الأردني، وحكم علاقة الرجل بزوجته ومدى حقه بمعاشرتها، وذلك من خلال عرض آراء الفقهاء، وأدلتهم والخروج بالرأي الراجح، وتم بيان أحكام جملة من المسائل ومنها: مكان إقامة المعتدة من الطلاق الرجعي، وحكم خروجها من مكان العدة، وسفر الزوج بها في فترة العدة، وقد تم بحث الموضوع دراسة مقارنة في الفقه الإسلامي وقانون الأحوال الشخصية الأردني. وأظهرت الدراسة جملة من النتائج أهمها: أن المرأة في فترة عدة الطلاق الرجعي تعد زوجة، ويحق لزوجها معاشرتها، وذلك يعد إرجاعاً لها، وأوصت الدراسة بتفصيل أحكام علاقة الرجل بمطلقته الرجعية من خلال عقد الندوات، والبرامج التلفزيونية، والتدريس في الجامعات.
أثر حوكمة الشركات على الأداء المالي للشركات الصغيرة والمتوسطة: دراسة حالة الشركات الأردنية
Authors: الشحادات محمد , لافي محمد 
Published: October 2024

تهدف هذه الدراسة إلى معرفة العلاقة بين حوكمة الشركات والأداء المالي في الشركات الصغيرة والمتوسطة الأردنية، حيث تتكون عينة الدراسة من الشركات الصغيرة والمتوسطة العاملة في الأردن التي حققت عددا من الشروط، منها أن يكون للشركة موقع الكتروني رسمي، وأن تكون تقاريرها المالية منشورة طيلة فترة الدراسة وبلغ عددها (40) شركة خلال مدة ست سنوات في الفترة الممتدة من (2013-2018)، ولتحقيق هدف الدراسة تم استخدام المنهج الوصفي التحليلـي باستخدام برنامج التحليل.IBM SPSS24 بالاعتماد على البيانات المالية للشركات الصغيرة والمتوسطة من خلال الموقع الالكتروني لها للوصول لمتغيرات الدراسة المتمثلة في حوكمة الشركات والمقاسه بكفاءة مجلس الإدارة (هيئة المديرين)، واستقلاليته، وحجمه، وفيما يتعلق في الأداء المالي المقيس بالعائد على الأصول واستخدام عمر الشركة وحجمها كمتغيرات ضابطة.
أظهرت نتائج الدراسة وجود علاقة بين حوكمة الشركات والأداء المالي للشركات المتوسطة والصغيرة في الأردن بالإضافة إلى عدم وجود علاقة بين كفاءة مجلس الإدارة والأداء المالي لهذه الشركات علاوة على وجود علاقة بين استقلالية مجلس الإدارة والأداء المالي ووجود علاقة بين حجم مجلس الإدارة والأداء المالي للشركات المتوسطة والصغيرة، توصي الدراسة الجهات المعنية بضرورة إصدار مجموعة من القوانين والتشريعات الصارمة لإجبار الشركات على تطبيق مبادئ الحوكمة للشركات الصغيرة والمتوسطة، ومراقبة تطبيقها من خلال ضرورة تقديم تقرير سنوي عن مدى التزامها بهذه المبادئ.
Acute kidney injury in COVID–19: A single–center experience in Nigeria
Authors: Ibrahim Olayinka Rasheed , Oloyede Taofeek , Gbadamosi Hakeem , Musa Yusuf , Aliu Rasaki , Bello Surajudeen Oyeleke , Alao Michael Abel , Suleiman Bello Mohammed , Adedoyin Olanrewaju Timothy 
Published: October 2024

Background & objective: Despite available data from developed countries, suggesting a high incidence of acute kidney injury (AKI) in coronavirus disease 2019 (COVID–19), there is scarce data from African countries, including Nigeria. We conducted this study to determine and document the incidence, the associated factors and the outcome (in–hospital mortality) of AKI among COVID–19 patients managed in a center in Nigeria.
Methodology: It was a retrospective review of confirmed COVID–19 cases managed at a center in Nigeria. AKI was defined using 2012 Kidney Disease: Improving Global Outcomes (KDIGO) creatinine criteria. We extracted relevant data from the electronic records of the COVID–19 patients admitted to our hospital and analyzed. Fischer's exact tests were used to test factors associated with AKI for discrete variables, Mann–Whitney U test was used for skewed continuous data, and T–test for continuous normal distribution variables.
Results: This study involved 41 of the 56 confirmed COVID–19 cases. The mean age was 45 ± 17.94 y. A majority of the patients were males (33; 80.5%). AKI occurred in 6 (14.6%) of the patients. Of the 6 AKI; 4 (66.7%) and 2 (33.3%) were in stages 1 and 3 respectively. One patient (16.7%) had had hemodialysis. Of the 6 with AKI, 3 died with a mortality rate of 50.0%. Factors associated with AKI included age above 45 years, body weakness, severe and critical COVID, urea > 10 mmol/l, and serum creatinine > 1.5 mg/dl. Only severe and critical disease was predictive of AKI (adjusted odds ratio 1.777, 95% CI 1.028, 3.074).
Conclusion: The results of our study show that AKI is common in severe and critical COVID–19 and is associated with a poor outcome.
Key words: Acute kidney injury; AKI; COVID–19; Mortality
Abbreviations: AKI – Acute kidney injury; KDIGO – Kidney Disease: Improving Global Outcomes 2012; eGFR – estimated glomerular filtration rate; MDRD – Modification of Diet in Renal Disease
Ethical Review Committee Approval: MOH/ADM/SUB/1152/1/374
Citation: Ibrahim OR, Taofeek Oloyede T , Gbadamosi H , Musa Y , Aliu R , Bello SO , Alao MA , Suleiman MS , Adedoyin OT. Acute kidney injury in COVID–19: A single–center experience in Nigeria. Anaesth. pain intensive care 2021;25(4):470–477. DOI: 10.35975/apic.v25i4.1567
Hemodynamic collapse and severe metabolic acidosis following propofol in the setting of undiagnosed mitochondrial dysfunction: a case report
Authors: Kim Daniel W. , Hu Amanda , Vaughn Douglas , Rajan Govind RC. 
Published: October 2024

Anesthetic management of patients with mitochondrial disorders is challenging due to their rare nature, and difficulties to develop evidence–based protocols for general anesthesia. We report a case of a 52–year–old male with hypertension, congenital deafness, optic neuritis, hypogonadism and myotonia, who developed severe refractory hypotension and bradycardia, and intractable severe lactic acidosis during induction of general anesthesia with fentanyl, propofol, and succinylcholine. The surgery had to be postponed and supportive management started. After extensive work–up, the patient was diagnosed with probable mitochondrial dysfunction. Patient returned for surgery under a different anesthetic regimen consisting of ketamine, fentanyl, ephedrine and dexmedetomidine; yielding a successful perioperative course and highlighting potential alternative strategies to manage anesthesia in patients with such disorders.
Key words: Mitochondrial Diseases; Propofol Infusion Syndrome; Lactic Acidosis
Abbreviations: MD – Mitochondrial disorders; PRIS – Propofol related infusion syndrome; HIPAA – Health Insurance Portability Accountability Act; MAP Mean arterial pressure; NMBAs – Neuromuscular blocking agents.
Citation: Kim DW, Hu A, Vaughn D, Rajan GRE. Hemodynamic collapse and severe metabolic acidosis following propofol in the setting of undiagnosed mitochondrial dysfunction: a case report. Anaesth. pain intensive care 2021;25(4):527–531. DOI: 10.35975/apic.v25i4.1587
Received: September 24, 2020. Reviewed: April 1, 2021, Accepted: May 31, 2021