bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased susceptibility of spontaneously hypertensive rats to ventricular tachyarrhythmias in early hypertension
Authors: Nguyen Thao P. , Sovari Ali A. , Pezhouman Arash , Iyer Shankar , Cao Hong , Ko Christopher Y. , Bapat Aneesh , Vahdani Nooshin , Ghanim Mostafa , Fishbein Michael C. , Karagueuzian Hrayr S. 
Published: January 2016

Key points
Hypertension is a risk factor for sudden cardiac death caused by ventricular tachycardia and fibrillation.
Whether hypertension in its early stage is associated with an increased risk of ventricular tachyarrhythmias is not known.
Based on experiments performed at the cellular and whole heart levels, we show that, even early in chronic hypertension, the hypertrophied and fibrotic ventricles of spontaneously hypertensive rats aged 5 to 6 months have already developed increased stress‐induced arrhythmogenicity, and this increased susceptibility to ventricular arrhythmias is primarily a result of tissue remodelling rather than cellular electrophysiological changes.
Our findings highlight the need for early hypertension treatment to minimize myocardial fibrosis, ventricular hypertrophy, and arrhythmias.
AbstractHypertension is a risk factor for sudden cardiac death caused by ventricular tachycardia and fibrillation (VT/VF). We hypothesized that, in early hypertension, the susceptibility to stress‐induced VT/VF increases. We compared the susceptibility of 5‐ to 6‐month‐old male spontaneously hypertensive rats (SHR) and age/sex‐matched normotensive rats (NR) to VT/VF during challenge with oxidative stress (H2O2; 0.15 mmol l−1). We found that only SHR hearts exhibited left ventricular fibrosis and hypertrophy. H2O2 promoted VT in all 30 SHR but none of the NR hearts. In 33% of SHR cases, focal VT degenerated to VF within 3 s. Simultaneous voltage‐calcium optical mapping of Langendorff‐perfused SHR hearts revealed that H2O2‐induced VT/VF arose spontaneously from focal activations at the base and mid left ventricular epicardium. Microelectrode recording of SHR hearts showed that VT was initiated by early afterdepolarization (EAD)‐mediated triggered activity. However, despite the increased susceptibility of SHR hearts to VT/VF, patch clamped isolated SHR ventricular myocytes developed EADs and triggered activity to the same extent as NR ventricular myocytes, except with larger EAD amplitude. During the early stages of hypertension, when challenged with oxidative stress, SHR hearts showed an increased ventricular arrhythmogenicity that stems primarily from tissue remodelling (hypertrophy, fibrosis) rather than cellular electrophysiological changes. Our findings highlight the need for early hypertension treatment to minimize myocardial fibrosis, ventricular hypertrophy, and arrhythmias.
A quantitative description of tubular system Ca2+ handling in fast‐ and slow‐twitch muscle fibres
Authors: Cully Tanya R. , Edwards Joshua N. , Murphy Robyn M. , Launikonis Bradley S. 
Published: January 2016

Key points
Current methods do not allow a quantitative description of Ca2+ movements across the tubular (t‐) system membrane without isolating the membranes from their native skeletal muscle fibre.
Here we present a fluorescence‐based method that allows determination of the t‐system [Ca2+] transients and derivation of t‐system Ca2+ fluxes in mechanically skinned skeletal muscle fibres. Differences in t‐system Ca2+‐handling properties between fast‐ and slow‐twitch fibres from rat muscle are resolved for the first time using this new technique.
The method can be used to study Ca2+ handling of the t‐system and allows direct comparisons of t‐system Ca2+ transients and Ca2+ fluxes between groups of fibres and fibres from different strains of animals.
AbstractThe tubular (t‐) system of skeletal muscle is an internalization of the plasma membrane that maintains a large Ca2+ gradient and exchanges Ca2+ between the extracellular and intracellular environments. Little is known of the Ca2+‐handling properties of the t‐system as the small Ca2+ fluxes conducted are difficult to resolve with conventional methods. To advance knowledge in this area we calibrated t‐system‐trapped rhod‐5N inside skinned fibres from rat and [Ca2+]t‐sys, allowing confocal measurements of Ca2+‐dependent changes in rhod‐5N fluorescence during rapid changes in the intracellular ionic environment to be converted to [Ca2+] transients in the t‐system ([Ca2+]t‐sys (t)). Furthermore, t‐system Ca2+‐buffering power was determined so that t‐system Ca2+ fluxes could be derived from [Ca2+]t‐sys (t). With this new approach, we show that rapid depletion of sarcoplasmic reticulum (SR) Ca2+ induced a robust store‐operated Ca2+ entry (SOCE) in fast‐ and slow‐twitch fibres, reducing [Ca2+]t‐sys to < 0.1 mm. The rapid activation of SOCE upon Ca2+ release was consistent with the presence of STIM1L in both fibre types. Abruptly introducing internal solutions with 1 mm Mg2+ and [Ca2+]cyto (28 nm–1.3 μm) to Ca2+‐depleted fibres generated t‐system Ca2+ uptake rates dependent on [Ca2+]cyto with [Ca2+]t‐sys reaching final plateaus in the millimolar range. For the same [Ca2+]cyto, t‐system Ca2+ fluxes of fast‐twitch fibres were greater than that in slow‐twitch fibres. In addition, simultaneous imaging of t‐system and SR Ca2+ signals indicated that both membrane compartments accumulated Ca2+ at similar rates and that SOCE was activated early during SR Ca2+ depletion.
Maintenance of Velocity and Power With Cluster Sets During High-Volume Back Squats
Authors: Tufano James J. , Conlon Jenny A. , Nimphius Sophia , Brown Lee E. , Seitz Laurent B. , Williamson Bryce D. , Haff G. Gregory 
Published: January 2016

Purpose:To compare the effects of a traditional set structure and 2 cluster set structures on force, velocity, and power during back squats in strength-trained men.Methods:Twelve men (25.8 ± 5.1 y, 1.74 ± 0.07 m, 79.3 ± 8.2 kg) performed 3 sets of 12 repetitions at 60% of 1-repetition maximum using 3 different set structures: traditional sets (TS), cluster sets of 4 (CS4), and cluster sets of 2 (CS2).Results:When averaged across all repetitions, peak velocity (PV), mean velocity (MV), peak power (PP), and mean power (MP) were greater in CS2 and CS4 than in TS (P < .01), with CS2 also resulting in greater values than CS4 (P < .02). When examining individual sets within each set structure, PV, MV, PP, and MP decreased during the course of TS (effect sizes 0.28–0.99), whereas no decreases were noted during CS2 (effect sizes 0.00–0.13) or CS4 (effect sizes 0.00–0.29).Conclusions:These results demonstrate that CS structures maintain velocity and power, whereas TS structures do not. Furthermore, increasing the frequency of intraset rest intervals in CS structures maximizes this effect and should be used if maximal velocity is to be maintained during training.
Figure-8 Strap Application: Immediate Alteration of Pectoralis Minor Length and Scapular Alignment During Arm-Lifting Exercise in Participants With Forward Shoulder Posture
Authors: Ko Chang-Hee , Cynn Heon-Seock , Lee Ji-Hyun , Yoon Tae-Lim , Choi Sil-Ah 
Published: January 2016

Context:Scapular bracing can correct scapular kinematics and restore normal scapular-muscle activity. However, there is little evidence to support the beneficial effects of a figure-8 strap, a type of scapular bracing, on muscle length, scapular alignment, and muscle activity during arm-lifting exercise.Objective:To investigate the immediate effect of a figure-8 strap on pectoralis minor length, scapular alignment, and scapular upward-rotator-muscle activity.Design:Cross-sectional study.Setting:Research laboratory.Participants:Fifteen male participants (age 22.1 ± 1.9 y, weight 68.2 ± 5.7 kg, height 176.2 ± 3.3 cm) with forward shoulder posture (FSP) were examined for pectoralis minor length and scapular alignment with and without the application of a figure-8 strap.Main Outcome Measures:Pectoralis minor length was measured using the Pectoralis Minor Index (PMI), scapular alignment was measured with FSP, and upper trapezius, lower trapezius, and serratus anterior muscle activity were measured using surface electromyography while participants performed an arm-lifting exercise. Data collected with and without applying a figure-8 strap were compared using a paired t-test.Results:Applying a figure-8 strap significantly decreased the PMI (P = .005) and scapular anterior tilting (P = .000). There were no differences in the muscle activity of the upper trapezius (P = .784), lower trapezius (P = .241), and serratus anterior muscles (P = .639).Conclusions:A figure-8 strap resulted in positive changes in pectoralis minor length and scapular alignment. The results support its use as a treatment aid in managing pectoralis minor length and scapular alignment during arm-lifting exercises.
Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England
Authors: Kendal Adrian R , Prieto-Alhambra Daniel , Arden Nigel K , Carr Andrew , Judge Andrew 
Published: January 2016

STUDY QUESTIONHow do 10 year mortality rates compare between patients undergoing metal-on-metal (MoM) hip resurfacing and those undergoing total hip replacement in England?SUMMARY ANSWERPatients in England with hip osteoarthritis who underwent MoM hip resurfacing between 1999 and 2012 have reduced long term mortality compared with those who underwent cemented and uncemented THR.
Peer victimisation during adolescence and its impact on depression in early adulthood: prospective cohort study in the United Kingdom
Authors: Bowes Lucy , Joinson Carol , Wolke Dieter , Lewis Glyn 
Published: January 2016

ObjectiveTo investigate the strength of the association between victimisation by peers at age 13 years and depression at 18 years.DesignLongitudinal observational study.SettingAvon Longitudinal Study of Parents and Children, a UK community based birth cohort.Participants6719 participants who reported on peer victimisation at age 13 years.Main Outcome MeasuresDepression defined according to international classification of diseases, 10th revision (ICD-10) criteria, assessed using the clinical interview schedule-revised during clinic assessments with participants when they were aged 18 years. 3898 participants had data on both victimisation by peers at age 13 years and depression at age 18 years.ResultsOf the 683 participants who reported frequent victimisation at age 13 years, 101 (14.8%) were depressed according to ICD-10 criteria at 18 years; of the 1446 participants reporting some victimisation at age 13 years, 103 (7.1%) were depressed at age 18 years; and of the 1769 participants reporting no victimisation at age 13 years, 98 (5.5%) were depressed at age 18 years. Compared with children who were not victimised those who were frequently victimised by peers had over a twofold increase in odds of depression (odds ratio 2.96, 95% confidence interval 2.21 to 3.97, P<0.001). This association was slightly reduced when adjusting for confounders (2.32, 1.49 to 3.63, P<0.001). The population attributable fraction suggested that 29.2% (95% confidence interval 10.9% to 43.7%) of depression at age 18 years could be explained by peer victimisation if this were a causal relation.ConclusionWhen using observational data it is impossible to be certain that associations are causal. However, our results are consistent with the hypothesis that victimisation by peers in adolescence is associated with an increase in the risk of developing depression as an adult.
Habenaria sahyadrica (Orchidaceae, Orchideae) a new species from the Western Ghats (India) with critical notes on allied taxa
Authors: Kumar Pankaj , Prabhukumar Konickal Mambetta , Nirmesh Thankappan Kureekadu , Sreekumar Vadakkethil Balakrishnan , Hareesh Vadakkoot Sankaran , Balachandran Indira 
Published: January 2016

Habenaria Willdenow (1805: 544) is a large genus represented by approximately 848 species making it by far the largest in subfamily Orchidoideae (Cribb 2001, Kurzweil 2009, Govaerts et al. 2014, Batista et al. 2011), with centres of diversity in Brazil, southern and central Africa, and East Asia (Kurzweil & Weber 1992). In India, it is represented by 72 species, of which 36 are endemic (Misra 2007). About 45 species of Habenaria are known to occur in the Western Ghats of India, of which 21 species are endemic (Jalal & Jayanthi 2012). In Kerala, 26 species were reported so far with 17 endemic (Sasidharan 2013).
Evaluating Regional and Global Hydrological Models against Streamflow and Evapotranspiration Measurements
Authors: Zhang Yongqiang , Zheng Hongxing , Chiew Francis H. S. , Arancibia Jorge Peña , Zhou Xinyao 
Published: January 2016

Abstract
Land surface and global hydrological models are often used to characterize global water and energy fluxes and stores and to model their future trajectories. This study evaluates estimates of streamflow and evapotranspiration (ET) obtained with a priori parameterization from a land surface model [CSIRO Atmosphere Biosphere Land Exchange (CABLE)] and a global hydrological model (H08) against a global dataset of streamflow from 644 largely unregulated catchments and ET from 98 flux towers and benchmarks their performance against two lumped conceptual daily rainfall–runoff models [modèle du Génie Rural à 4 paramètres Journalier (GR4J) and a simplified version of the HYDROLOG model (SIMHYD)]. The results show that all four models perform poorly in simulating the monthly and annual runoff values, with the rainfall–runoff models outperforming both CABLE and H08. The model biases in runoff are generally reflected as a complementary opposite bias in ET. All models can generally reproduce the observed seasonal and interannual runoff variability. The correlations between the modeled and observed runoff time series are reasonable, with the rainfall–runoff models performing slightly better than CABLE and H08 at the monthly time scale and all four models performing similarly at the annual time scale. The results suggest that while the land surface and global hydrological models cannot adequately simulate the actual runoff time series and long-term average volumes, they can reasonably simulate the monthly and interannual runoff variability and trends and can therefore be reliably used for broadscale or comparative regional and global water and energy balance assessments and simulations of future trajectories. They can be improved through validating the models or calibrating some of the more sensitive and less physically based parameters.
An Experimental Test of Deviant Modeling
Authors: Gallupe Owen , Nguyen Holly , Bouchard Martin , Schulenberg Jennifer L. , Chenier Allison , Cook Katie D. 
Published: January 2016

Objectives: Test the effect of deviant peer modeling on theft as conditioned by verbal support for theft and number of deviant models. Methods: Two related randomized experiments in which participants were given a chance to steal a gift card (ostensibly worth CAN$15) from the table in front of them. Each experiment had a control group, a verbal prompting group in which confederate(s) endorsed stealing, a behavioral modeling group in which confederate(s) committed theft, and a verbal prompting plus behavioral modeling group in which confederate(s) did both. The first experiment used one confederate; the second experiment used two. The pooled sample consisted of 335 undergraduate students. Results: Participants in the verbal prompting plus behavioral modeling group were most likely to steal followed by the behavioral modeling group. Interestingly, behavioral modeling was only influential when two confederates were present. There were no thefts in either the control or verbal prompting groups regardless of the number of confederates. Conclusions: Behavioral modeling appears to be the key mechanism, though verbal support can strengthen the effect of behavioral modeling.
Words, Ideas and Ideology in the Shifting Sand of Markets
Authors: Qadeer Imrana , Arathi P.M.  
Published: January 2016

The transformation of existing knowledge or production of new knowledge is the focus of this article. This theme is explored using women’s health, actions and perceptions, and their interpretations—within a public health perspective—as these evolve around the currently most talked about high-tech obstetric intervention—the practice of surrogacy. The interpretations of words such as production, reproduction, labour and work are central to the present understanding of surrogacy in different societies. At a point in time when social sciences are striving to understand complexities, interconnections and praxis, this article offers a possibility of judicious use of technology and a glimpse, however brief, of man’s natural essence—humanness—the cementing factor in the alternate structure of society waiting to overcome the present conflict between the global hegemonic and democratic forces. The article argues that in contemporary India, the sections where surrogates come from see surrogacy in different ways, and that has to be the starting point for analysis but not the end. Indian law-makers take advantage of this confusion about the nature of surrogacy. It buries the non-exploitative potential of procreation under the ‘compensation for agreeing’ to be a surrogate, denies her rights and undermines the value of gestational motherhood as compared to genetic identity—thus, killing several birds with one stone!
European Cooperative Acute Stroke Study-4: Extending the time for thrombolysis in emergency neurological deficits ECASS-4: ExTEND
Authors: Amiri Hemasse , Bluhmki Erich , Bendszus Martin , Eschenfelder Christoph C , Donnan Geoffrey A , Leys Didier , Molina Carlos , Ringleb Peter A , Schellinger Peter D , Schwab Stefan , Toni Danilo , Wahlgren Nils , Hacke Werner 
Published: January 2016

Rationale and hypothesis Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is an effective and approved therapy for acute ischemic stroke within 4.5 h of onset except for USA, Canada, Croatia, and Moldovia with a current 3 h label. We hypothesized that ischemic stroke patients selected with significant penumbral mismatch on magnetic resonance imaging (MRI) at 4.5–9 h after onset of stroke will have improved clinical outcomes when given intravenous rt-PA (alteplase) compared to placebo. Study design ECASS-4: ExTEND is an investigator driven, phase 3, randomized, multi-center, double-blind, placebo-controlled study. Ischemic stroke patients presenting within 4.5 and 9 h of stroke onset, who fulfil clinical requirements (National Institutes of Health Stroke Score (NIHSS) 4–26 and pre-stroke modified Rankin Scale (mRS) 0–1) will undergo MRI. Patients who meet imaging criteria (infarct core volume <100 ml, perfusion lesion: infarct core mismatch ratio >1.2 and perfusion lesion minimum volume of 20 ml) additionally will be randomized to either rt-PA or placebo. Study outcome The primary outcome measure will be the categorical shift in the mRS at day 90. Clinical secondary outcomes will be disability at day 90 dichotomized as favorable outcome mRS 0–1 at day 90. Tertiary endpoints include reduction in the NIHSS by 11 or more points or reaching 0–1 at day 90, reperfusion and recanalization at 24 h post stroke as well as depression, life quality, and cognitive impairment at day 90. Safety endpoints will include symptomatic intracranial hemorrhage (ICH) and death.
Mixed Dentition Space Analysis in a Sudanese Population
Authors: Alzubir Abdelbagi A. , Abass Shaza , Ali Mohamed A. E. 
Published: January 2016

Objective To test the applicability of the Tanaka and Johnston equation for prediction of the mesiodistal width of unerupted permanent teeth in a Sudanese population and to develop a new prediction equation for this specific population if necessary. Design: A descriptive, cross-sectional study. Settings: School-based study. Subjects and Methods Two hundred and fifty subjects (118 males and 132 females) age 13 – 19 years were randomly selected from two public secondary high schools in Khartoum State. Mesiodistal widths of the upper and lower permanent canines, first and second premolars (CPM) as well as the mandibular permanent incisors (MPI) were measured manually on the dental casts using a digital caliper. The predicted values of the mesiodistal widths were statistically compared with the respective actual sum of the canine and premolars of the same quadrant. Results Moderate correlation coefficients were found between the sum of the mesiodistal width of the MPI and the sum of the CPM in males (0.618 for mandibular arch and 0.626 for maxillary arch) and females (0.726 for mandibular arch and 0.680 for maxillary arch). A low coefficient of determination was recorded (0.45 and 0.48) in both jaws for combined genders. Conclusions The Tanaka and Johnston equations overestimated the actual mesiodistal width of CPM in both arches for males and females. New prediction equations with more accurate regression parameters were proposed for the Sudanese population.
Elevated high-sensitive troponin T on admission is an indicator of poor long-term outcome in patients with subarachnoid haemorrhage: a prospective observational study
Authors: Oras Jonatan , Grivans Christina , Bartley Andreas , Rydenhag Bertil , Ricksten Sven-Erik , Seeman-Lodding Helene 
Published: January 2016

Abstract
Background
Patients with subarachnoid haemorrhage (SAH) frequently develop cardiac complications in the acute phase after the bleeding. Although a number of studies have shown that increased levels of cardiac biomarkers after SAH are associated with a worse short-term prognosis, no prospective, consecutive study has assessed the association between biomarker release and long-term outcome. We aimed to evaluate whether the cardiac biomarkers, high-sensitive troponin T (hsTnT) and N-terminal pro B-type natriuretic peptide (NTproBNP), were associated with poor 1-year neurological outcome and cerebral infarction due to delayed cerebral ischaemia (CI-DCI).

Methods
In this single-centre prospective observational study, all consecutive patients admitted to our neurointensive care unit from January 2012 to December 2013 with suspected/verified SAH with an onset of symptoms <72 hours were enrolled. Blood samples for hsTnT and NTproBNP were collected during three consecutive days following admission. Patients were followed-up after 1 year using the Glasgow Outcome Scale Extended (GOSE). Poor neurological outcome was defined as GOSE ≤4.

Results
One hundred and seventy seven patients with suspected SAH were admitted during the study period; 143 fulfilled inclusion criteria and 126 fulfilled follow-up. Forty-one patients had poor 1-year outcome and 18 had CI-DCI. Levels of hsTnT and NTproBNP were higher in patients with poor outcome and CI-DCI. In multivariable logistic regression modelling age, poor neurological admission status, cerebral infarction of any cause and peak hsTnT were independently associated with poor late outcome. Both peak hsTnT and peak NTproBNP were independently associated with CI-DCI.

Conclusion
Increased serum levels of the myocardial damage biomarker hsTnT, when measured early after onset of SAH, are independently associated with poor 1-year outcome. Furthermore, release of both hsTnT and NTproBNP are independently associated with CI-DCI. These findings render further support to the notion that troponin release after SAH is an ominous finding. Future studies should evaluate whether there is a causal relationship between early release of biomarkers of myocardial injury after SAH and neurological sequelae.