bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐ and long‐term perinatal outcome in twin pregnancies affected by weight discordance
Authors: Vedel Cathrine , Oldenburg Anna , Worda Katharina , Larsen Helle , Holmskov Anni , Andreasen Kirsten R. , Uldbjerg Niels , Ramb Jan , Bødker Birgit , Skibsted Lillian , Sperling Lene , Hinterberger Stefan , Krebs Lone , Zingenberg Helle , Weiss Eva‐Christine , Strobl Isolde , Laursen Lone , Christensen Jeanette T. , Ersbak Vibeke , Stornes Inger , Krampl‐Bettelheim Elisabeth , Tabor Ann , Rode Line 
Published: November 2016

AbstractIntroductionThe objective was to investigate the association between chorionicity‐specific intertwin birthweight discordance and adverse outcomes including long‐term follow up at 6, 18, and 48–60 months after term via Ages and Stages Questionnaire.Material and methodsIn this secondary analysis of a cohort study (Oldenburg et al., n = 1688) and a randomized controlled trial (PREDICT study, n = 1045) twin pairs were divided into three groups according to chorionicity‐specific birthweight discordance: <75th percentile, 75th–90th percentile and >90th percentile. Information on infant mortality, admittance to neonatal intensive care units, and gestational age at delivery was available for all pairs. Detailed neonatal outcomes were available for 656 pairs from PREDICT, of which 567 pairs had at least one Ages and Stages Questionnair follow‐up. Logistic regression models were used for dichotomous outcomes. Ages and Stages Questionnair scores were compared using the method of generalized estimating equation to account for the correlation within twins.ResultsThe 75th and 90th percentiles for birthweight discordance were 14.8 and 21.4% for monochorionic and 16.0 and 23.8% for dichorionic twins. After adjustment for small for gestational age and gender, birthweight discordance >75th and >90th percentile was associated with induced delivery <34 weeks [odds ratio 1.71 (95% confidence interval 1.11–2.65) and odds ratio 2.83 (95% confidence interval 1.73–4.64), respectively]. Discordance >75th‐percentile was associated with an increased risk of infant mortality after 28 days [odds ratio 4.69 (95% confidence interval 1.07–20.45)] but not with major neonatal complications or with low mean Ages and Stages Questionnair scores at 6, 18, and 48–60 months after term.ConclusionChorionicity‐specific intertwin birthweight discordance is a risk factor for induced preterm delivery and infant mortality, but not for lower scores for neurophysiological development at 6, 18, and 48–60 months.
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy
Authors: Abu El‐Asrar Ahmed M. , Ahmad Ajmal , Alam Kaiser , Siddiquei Mohammad Mairaj , Mohammad Ghulam , Hertogh Gert De , Mousa Ahmed , Opdenakker Ghislain 
Published: November 2016

AbstractPurposeExtracellular matrix metalloproteinase inducer (EMMPRIN) promotes angiogenesis through matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) production. We investigated the expression levels of EMMPRIN and correlated these levels with VEGF, MMP‐1 and MMP‐9 in proliferative diabetic retinopathy (PDR). In addition, we examined the expression of EMMPRIN in the retinas of diabetic rats and the effect of EMMPRIN on the induction of angiogenesis regulatory factors in human retinal microvascular endothelial cells (HRMECs).MethodsVitreous samples from 40 PDR and 19 non‐diabetic patients, epiretinal membranes from 12 patients with PDR, retinas of rats and HRMECs were studied by enzyme‐linked immunosorbent assay (ELISA), immunohistochemistry, Western blot analysis, zymography analysis and RT‐PCR.ResultsWe showed a significant increase in the expression of EMMPRIN, VEGF, MMP‐1 and MMP‐9 in vitreous samples from PDR patients compared with non‐diabetic controls (p < 0.0001; p = 0.001; p = 0.009; p < 0.0001, respectively). Significant positive correlations were found between the levels of EMMPRIN and the levels of VEGF (r = 0.38; p = 0.003), MMP‐1 (r = 0.36; p = 0.005) and MMP‐9 (r = 0.46; p = 0.003). In epiretinal membranes, EMMPRIN was expressed in vascular endothelial cells and stromal cells. Significant increase of EMMPRIN mRNA was detected in rat retinas after induction of diabetes. EMMPRIN induced hypoxia‐inducible factor‐1α, VEGF and MMP‐1 expression in HRMEC.ConclusionsThese results suggest that EMMPRIN/MMPs/VEGF pathway is involved in PDR angiogenesis.
Primary rhegmatogenous retinal detachment – surgical methods and anatomical outcome
Authors: Haugstad Marta , Moosmayer Stefan , Bragadόttir Ragnheiður 
Published: November 2016

AbstractPurposeThe aim of the study was to evaluate the anatomical success of surgical management of primary rhegmatogenous retinal detachment (RRD) and to compare the anatomical outcomes from different surgical techniques.MethodsDuring 2012, 517 consecutive eyes (514 patients) were operated by 11 surgeons at the Department of Ophthalmology, Oslo University Hospital. Patient records were retrospectively analysed with no exclusions. Main outcome measures were primary and final anatomical success. Primary anatomical success was defined as retinal reattachment 6 months after primary surgery with reoperations excluded. Final anatomical success was defined as retinal reattachment 6 months after primary surgery with reoperations included.ResultsIncidence of RRD was 18.6 eyes per 100 000 person‐years. The macula was detached in 50.5% of the eyes at baseline. Of 517 operated eyes, 317 (61.3%) underwent pars plana vitrectomy (PPV), 23 (4.5%) pars plana vitrectomy together with a scleral buckle (PPV‐SB), 175 (33.9%) scleral buckle (SB) surgery and two (0.4%) pneumatic retinopexy (PR). Primary anatomical success was 89.0% in the PPV group, 87.0% in the PPV‐SB group and 85.7% in the SB group. Final anatomical success was 98.1% in the PPV group, 100% in the PPV‐SB group and 99.4% in the SB group. Factors which were correlated to the redetachment were detachment of more than 6 clock hours (p = 0.003) and visual acuity (VA) on Snellen chart <0.5 (p = 0.02) at baseline.ConclusionThis study showed no significant differences in the surgical success rates in the treatment of RRD between pars plana vitrectomy, scleral buckle or the combined procedure of vitrectomy and buckle. Factors which were found to be correlated to the redetachment of the retina were large detachment and low VA.
Non‐alcoholic fatty liver diseases and risk of colorectal neoplasia
Authors: Ahn J. S. , Sinn D. H. , Min Y. W. , Hong S. N. , Kim H. S. , Jung S.‐H. , Gu S. , Rhee P.‐L. , Paik S. W. , Son H. J. , Gwak G.‐Y. 
Published: November 2016

SummaryBackgroundNon‐alcoholic fatty liver disease (NAFLD) is associated with colorectal neoplasia. Yet, NAFLD ranges from simple steatosis to steatohepatitis with advanced fibrosis.AimTo investigate the risk of colorectal neoplasia according to the presence and severity of NAFLD.MethodsA total of 26 540 asymptomatic adults who underwent same day first‐time colonoscopy and abdominal ultrasonography as a health check‐up programme were analysed. NAFLD was diagnosed by ultrasonography. Advanced colorectal neoplasia was defined as an invasive cancer or adenoma that was at least 10 mm in diameter, had high‐grade dysplasia, or had villous histological characteristics or any combination thereof.ResultsNAFLD patients had a higher prevalence of any colorectal neoplasia (38.0% vs. 28.9%) and advanced colorectal neoplasia (2.8% vs. 1.9%) compared to those without NAFLD. In a multivariable model adjusted for age, sex, smoking, alcohol, body mass index, first‐degree family history of colorectal cancer, aspirin use and metabolic factors, the odd ratios comparing patients with NAFLD to those without were 1.10 [95% confidence interval (CI): 1.03–1.17] for any colorectal neoplasia and 1.21 (95% CI: 0.99–1.47) for advanced colorectal neoplasia. When NAFLD patients were further stratified according to the non‐invasive parameters of liver disease severity, the risk of any colorectal neoplasia or advanced colorectal neoplasia was higher for those with severe liver diseases than those with mild liver diseases.ConclusionsThe presence and severity of NAFLD were closely associated with any colorectal neoplasia and advanced colorectal neoplasia, suggesting that clinicians should be aware of the increased risk of colorectal neoplasia in patients with NAFLD.
How to improve rural tourism development in Chinese suburban villages? Empirical findings from a quantitative analysis of eight rural tourism destinations in Beijing
Authors: Dai Linlin , Wan Li , Xu Bixia , Wu Bihu 
Published: November 2016

Rural tourism has been an important engine for rural development and regeneration. In China, rural tourism is widely encouraged in the less developed regions to mitigate poverty and promote harmonious urban–rural development. Existing research literature finds that the perceptions of stakeholders towards rural tourism development are critical of the final economic and social outcomes. Nonetheless, most research focuses on the perception of a single stakeholder group. In this paper, we fill the research gap by simultaneously examining the perceptions of both the local tourism service providers and the tourists. We select eight Beijing suburban villages that typify the rural tourism development trends in Beijing, and collect sample data from 433 local service providers and 815 tourists. The questionnaire covers a wide range of perceptual variables, with particular focus on how the two stakeholder groups respond differently to the possible approaches to improve rural tourism development. The Partial Least Squares (PLS) regression method is employed to identify the key impact factors for each group. Our test shows that diversifying the tourism products and improving marketing coverage are two approaches that are favoured by both the local service providers and the tourists. However, different concerns are revealed for other approaches, such as improving service quality, increasing accommodation capacity and providing collective tourism activities. We also discover that rural tourism development may cause dramatic social and demographic changes to suburban villages, the impacts of which should be taken into account for development scheme appraisal. This research helps to clarify the policy contexts for rural tourism development and points out the possible priority areas for future research.
Blood flow evaluation using PINPOINT® in a case of incarcerated inguinal hernia: A case report
Authors: Ryu Shunjin , Yoshida Masashi , Ohdaira Hironori , Tsutsui Nobuhiro , Suzuki Norihiko , Ito Eisaku , Nakajima Keigo , Yanagisawa Satoru , Kitajima Masaki , Suzuki Yutaka 
Published: November 2016

AbstractIndocyanine green (ICG) fluorescence for intestinal blood flow has been reported, but application during laparoscopic surgery for incarcerated inguinal hernia has not been reported. Here, we report the case of a patient with an incarcerated inguinal hernia in whom the bowel was preserved after evaluation of intestinal blood flow with ICG fluorescence using PINPOINT®, a brightfield full‐color, near‐infrared fluorescence camera. A man in his 80s was diagnosed with incarcerated inguinal hernia and underwent laparoscopic surgery. The ascending colon and mesentery showed deep red discoloration on gross evaluation. However, intravenous injection of ICG revealed uniform fluorescence of the mesentery and bowel wall, indicating the absence of irreversible ischemic changes of the bowel. As such, no resection was performed, and transabdominal preperitoneal patch plasty was completed. The patient had a good postoperative course. In this case, ICG fluorescence with the PINPOINT was useful to avoid bowel resection during laparoscopic surgery.
‘Putting music on’: everyday leisure activities, choice‐making and person‐centred planning in a supported living scheme
Authors: Hassan Nedim 
Published: November 2016

Accessible summaryEssential Lifestyle Plans are a good way for people with learning disabilities and their support workers to tell people about things they like to do, such as listening to music.These plans also tell people about the things that they need, like what medicine they may need to take.Sometimes it is not easy to put the things we like to do at home into these plans because there are lots of things we do every day.People need to think carefully about how the things we choose to do at home can be put into Essential Lifestyle Plans that are written for us and with us.AbstractBackground:Person‐centred planning, which commonly becomes formalised within services for people with learning disabilities through an Essential Lifestyle Plan (ELP), was intended to help place the choices of individuals at the forefront of service provision. However, beyondUKgovernment policy rhetoric, scholars have raised issues regarding the capacity of person‐centred planning to empower people with learning disabilities to make choices about various aspects of their lives. This article assesses these debates, paying attention to the relationship betweenELPs and choices made in relation to leisure activities.Materials and Methods:To examine leisure activities and choice‐making in depth, the article draws upon ethnographic research conducted with four adults living in a supported living scheme. It focuses upon their domestic musical activities, connecting data derived from participant observation with the contents ofELPs.Results:This study found that person‐centred planning underplayed processes involved with articulations of musical choice and also the peculiarities of the settings in which choices were made. It also found that leisure preferences expressed inELPs did not effectively convey the richness and sociocultural significance of everyday domestic musical activities within the supported living scheme.Conclusions:Person‐centred planning should not be divorced from social context, relationships and differing degrees of dependency. Domestic leisure activities such as listening to music, while not necessarily ‘meaningful’ in the terms laid out inUKpolicy discourse, can become crucial resources for social bonding for people with learning disabilities. Thus, they should be considered carefully as part of a dynamic, socially situated and person‐centred planning process.
Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea
Authors: Francis J P , Richmond P C , Strickland D , Prescott S L , Pomat W S , Michael A , Nadal-Sims M A , Edwards-Devitt C J , Holt P G , Lehmann D , van den Biggelaar A H J 
Published: November 2016

Summary
In areas where Streptococcus pneumoniae is highly endemic, infants experience very early pneumococcal colonization of the upper respiratory tract, with carriage often persisting into adulthood. We aimed to explore whether newborns in high-risk areas have pre-existing pneumococcal-specific cellular immune responses that may affect early pneumococcal acquisition. Cord blood mononuclear cells (CBMC) of 84 Papua New Guinean (PNG; high endemic) and 33 Australian (AUS; low endemic) newborns were stimulated in vitro with detoxified pneumolysin (dPly) or pneumococcal surface protein A (PspA; families 1 and 2) and compared for cytokine responses. Within the PNG cohort, associations between CBMC dPly and PspA-induced responses and pneumococcal colonization within the first month of life were studied. Significantly higher PspA-specific interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-5, IL-6, IL-10 and IL-13 responses, and lower dPly-IL-6 responses were produced in CBMC cultures of PNG compared to AUS newborns. Higher CBMC PspA-IL-5 and PspA-IL-13 responses correlated with a higher proportion of cord CD4 T cells, and higher dPly-IL-6 responses with a higher frequency of cord antigen-presenting cells. In the PNG cohort, higher PspA-specific IL-5 and IL-6 CBMC responses were associated independently and significantly with increased risk of earlier pneumococcal colonization, while a significant protective effect was found for higher PspA-IL-10 CBMC responses. Pneumococcus-specific cellular immune responses differ between children born in pneumococcal high versus low endemic settings, which may contribute to the higher risk of infants in high endemic settings for early pneumococcal colonization, and hence disease.
A novel hotspot of vertebrate endemism and an evolutionary refugium in tropical Australia
Authors: Oliver Paul M. , Laver Rebecca J. , De Mello Martins Felipe , Pratt Renae C. , Hunjan Sumitha , Moritz Craig C. 
Published: November 2016

AbstractAimIn lineages or regions that are rife with morphologically cryptic taxa, hotspots of local endemism may remain overlooked when genetic data are unavailable. Here we examine the genetic diversity and evolutionary origins of lizard communities occurring in a relatively restricted, isolated and heretofore poorly surveyed region of limestone karst in northern Australia.LocationThe Devonian Reef System (DRS), an iconic range of exposed weathered limestone at the margin of the Australian Arid Zone (AAZ) and Monsoonal Tropics (AMT) in north‐west Australia, that is widely recognized for its cultural, geological and palaeontological significance.MethodsIn collaboration with local landowners, we sampled four different gecko genera at sites spanning the DRS and adjacent biomes. We then used measures of genetic divergence, neutrality tests, Bayesian dating and hierarchical approximate Bayesian computational (HABC) approaches to identify divergent lineages, test for shared biogeographic history and compare patterns of genetic differentiation in lineages with different ecologies (saxicoline, arboreal and terrestrial).ResultsAmongst saxicoline taxa, we identified 11 genetically divergent lineages that appear to be endemic to the DRS. Generalists and arboreal lineages showed no evidence of endemism in the DRS. Estimated divergence dates and patterns of distribution indicate that endemic lineages have persisted since the Plio‐Pleistocene (or even earlier). Taxa in an old endemic Australian Gondwanan radiation showed evidence of longer persistence and isolation than those in radiations with more recent immigrant origins.Main ConclusionsThe DRS is a heretofore overlooked hotspot of vertebrate endemism and persistence. Areas with distinctive underlying geology that provide microrefugia (such as karst) in tropical regions across the globe are likely important refugia for biodiversity at both ecological and evolutionary scales. They warrant further focused survey efforts (including genetics‐based assessments of diversity) and ongoing conservation attention.
When preschoolers follow their eyes and older children follow their noses: visuo‐olfactory social affective matching in childhood
Authors: Cavazzana Annachiara , Wesarg Christiane , Parish‐Morris Julia , Lundström Johan N. , Parma Valentina 
Published: November 2016

AbstractRecognition of emotional facial expressions is a crucial skill for adaptive behavior that most often occurs in a multi‐sensory context. Affective matching tasks have been used across development to investigate how people integrate facial information with other senses. Given the relative affective strength of olfaction and its relevance in mediating social information since birth, we assessed olfactory–visual matching abilities in a group of 140 children between the ages of 3 and 11 years old. We presented one of three odor primes (rose, fish and no‐odor, rated as pleasant or unpleasant by individual children) before a facial choice task (happy vs. disgusted face). Children were instructed to select one of two faces. As expected, children of all ages tended to choose happy faces. Children younger than 5 years of age were biased towards choosing the happy face, irrespective of the odor smelled. After age 5, an affective matching strategy guided children's choices. Smelling a pleasant odor predicted the choice of happy faces, whereas smelling the unpleasant or fish odor predicted the choice of disgusted faces. The present study fills a gap in the developmental literature on olfactory‐visual affective strategies that affect decision‐making, and represents an important step towards understanding the underlying developmental processes that shape the typical social mind.
FUT2 non‐secretor status is associated with Type 1 diabetes susceptibility in Japanese children
Authors: Ihara K. , Fukano C. , Ayabe T. , Fukami M. , Ogata T. , Kawamura T. , Urakami T. , Kikuchi N. , Yokota I. , Takemoto K. , Mukai T. , Nishii A. , Kikuchi T. , Mori T. , Shimura N. , Sasaki G. , Kizu R. , Takubo N. , Soneda S. , Fujisawa T. , Takaya R. , Kizaki Z. , Kanzaki S. , Hanaki K. , Matsuura N. , Kasahara Y. , Kosaka K. , Takahashi T. , Minamitani K. , Matsuo S. , Mochizuki H. , Kobayashi K. , Koike A. , Horikawa R. , Teno S. , Tsubouchi K. , Mochizuki T. , Igarashi Y. , Amemiya S. , Sugihara S. ,   The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
Published: November 2016

AbstractAimTo examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children.MethodsWe analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined.ResultsThe se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20–2.35); corrected P value = 0.0075].ConclusionsThe FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.
TPO‐RAs in pITP: description of a case series and analysis of predictive factors for response
Authors: Mazzucconi Maria Gabriella , Santoro Cristina , Baldacci Erminia , De Angelis Federico , Chisini Marta , Ferrara Grazia , Volpicelli Paola , Foà Roberto 
Published: November 2016

AbstractObjectiveTo report our experience concerning sustained response (SR) after TPO‐RA discontinuation in adult pITP patients and to identify possible predictive factors for outcome.MethodsThirty‐nine pITP patients who received a TPO‐RA were evaluated. Response (R) was defined as a platelet count ≥30 × 109/L and at least a twofold increase in the baseline count and complete response (CR) as a platelet count ≥100 × 109/L, in the absence of bleeding. Durable response (DR) was defined as a R/CR persisting ≥4 wk with a stable dose of TPO‐RA, and SR as the first assessed platelet count ≥30 × 109/L, available at more than 4 wk after discontinuation of TPO‐RA, in the absence of other concomitant or rescue therapies.ResultsTwenty‐nine/39 (74%) were responders: 18 (46%) reached a CR and 11 (28%) a R. A DR was observed in 16/29 (55%) responders. Seven SR (18%) were reached: five of seven patients achieved a SR from a prior DR. CR was statistically associated with the achievement of a subsequent DR: 13/18 (72%) CR patients obtained a DR, while only three of 11 (27%) R ones did (P = 0.027).ConclusionsCR was a significant prognostic factor for the achievement of a DR. Moreover, we observed a trend for DR patients to obtain a subsequent SR.
Familial acquired thrombotic thrombocytopenic purpura in siblings – no immunogenetic link with associated human leucocyte antigens
Authors: Gödel Philipp , Fischer Julia , Scheid Christoph , Gathof Birgit S. , Wolf Jürgen , Rybniker Jan 
Published: November 2016

AbstractAcquired immunoglobulin G (IgG)‐mediated thrombotic thrombocytopenic purpura (TTP) has not yet been described in non‐twin siblings. We report two cases of acquired TTP in Caucasian sisters with inactive ADAMTS13 metalloprotease due to ADAMTS13 autoantibodies suggesting a role of genetic determinants in this life‐threatening disease. However, human leucocyte antigen (HLA) class II types presumably associated with acquired TTP were not identified in the patients, indicating that HLA class II typing may not be useful in acquired TTP risk assessment of family members.