bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Distribution and Trend Analysis of Groundwater Contaminants Using the ArcGIS Geostatistical Analysis (Kriging) Algorithm; The case of Gurage Zone, Ethiopia
Authors: Ayalew Abel Amsalu , Tegenu Moges Tariku 
Published: October 2024

Abstract

The study explores the spatial distribution and trends of groundwater pollutants focusing on calcium and four other key water quality parameters in the Gurage Zone, Ethiopia, in 2024. It uses the ArcGIS geostatistical analysis tool with the Kriging algorithm to map and analyze the spatial variability of contaminants. The primary aim is to identify areas with high levels of pollutants and understand spatial patterns. It identifies contamination hotspots associated with natural processes and human activities. Twenty-seven samples were collected from various sites, and parameters like calcium, total dissolved solids, hardness, conductivity, and alkalinity were measured. The findings show that the distribution of contaminants varies significantly across different areas, with some areas exceeding safe drinking water limits. It reveals that the southern region has the highest calcium concentration, with shallow local boreholes. The deeper wells have higher dissolved solids, hardness, and conductivity. The spatial trend shows increased pollutant levels along the X and Y axes. The Kriging model effectively predicted contaminants in unsampled areas, offering a reliable technique aimed at groundwater quality monitoring. The study provides important insights for the local authorities to implement interventions for groundwater protection in the Gurage Zone.
Hydrodynamic model-driven evolutionary algorithm-based operation optimization of an experimental drainage pumping station
Authors: Li Xuan , Xue Shuhong , Hou Jingming , Guo Yuan , Liu Yuan , Ma Huan , Zhang Tao , Wang Shu 
Published: October 2024

ABSTRACT

The effective operation of pumping stations plays a crucial role in urban flood management. However, challenges persist in optimizing pumping station operations, including inaccuracies in characterizing flood propagation and the high computational costs associated with optimization. This study introduces a novel optimization approach for pumping station operation that integrates a hydrodynamic model with evolutionary algorithms, leveraging data-driven technology. The method iteratively computes operation rules using the adaptive particle swarm optimization (APSO) algorithm to identify optimal solutions. The hydrodynamic model accurately simulates flood propagation and provides hydraulic parameters for the objective function and constraints of the APSO algorithm. With the predictive capability of the Kriging model, the optimization enhances efficiency by reducing the frequency of calls to the hydrodynamic model. A study case of a flood management digital twin experimental platform was then taken for the application. Compared to initial operation rules, the objective function value of the proposed method is reduced by 28.7, 32.5, and 25%, respectively, under varying magnitudes of unsteady flood inflows, demonstrating high performances in both flood mitigation and operation cost control. Moreover, the method only requires 70 calls to the hydrodynamic model to formulate the decision operation rule.
A Comprehensive and Concise Review on Significance of Potent Peptide; Amyloid Beta (Aβ) in Progression of Alzheimer’s Disease
Authors: Aziz Namra , Wal Pranay , Singh Yash Kumar , Kumar Pankaj , Singh Bhupendra 
Published: October 2024

Background:
A condition associated with neurodegeneration is termed Alzheimer's,
characterized by mental as well as memory deterioration. Amyloid beta (Aβ) is a type of peptide
that accumulates within the central nervous system and causes plaque, cerebral amyloid angiopathy
(CAA), and neurodegeneration (loss of acetylcholine). These peptide forms have a major impact
on neuronal damage.

Objective:
Our goal is to provide an overview of Aβ's potential involvement in developing
Alzheimer's condition.

Methods:
An extensive literature review was done using the standard keywords “amyloid beta”,
“amyloid beta precursor protein”, “secretase”, and “Alzheimer’s disease” from the databases SCOPUS,
PubMed, Elsevier, and Web of Science.

Conclusion:
Amyloid-β precursor protein (AβPP) is converted to Aβ through a series of divisions
by β and γ secretases, which are found in lipid rafts. The control of these elements is believed to
have a significant role in Aβ production throughout the aetiology of Alzheimer's disease (AD). In
conclusion, research on Aβ aggregation and clearance has been active in preventing and curing
Alzheimer's disorders. Thus, the purpose of this article was to describe the pharmacological function
of Aβ peptide plus its process of aggregation.
Molecular Docking and In Silico ADME(T) Evaluation of Selective Phytochemical Inhibitors of VEGF2 Target for the Treatment of Diabetic Retinopathy
Authors: Alagarsamy Veerachamy , Sulthana Mohaideen Thasthagir , Solomon Viswas Raja , Satishchandra Aithamraju , Kulkarni Vishaka Sumant , Narendhar Bandi , Sangeetha Dhanwar , Murugesan Sankaranarayanan 
Published: October 2024

Background:
Diabetic retinopathy (DR) is the leading cause of vision loss in diabetic patients.
Currently, the treatment involves the use of glucocorticoids or a VEGF antagonist, which are
"off-label" at present. However, the conventional method of drug discovery and development is a
time-consuming process that requires more than a decade of meticulous research and huge financial
support. While there are a few effective small organic molecules against DR that were identified
many years ago, nutraceuticals - naturally available functional foods containing vitamins, antioxidants,
minerals, fatty acids, and amino acids - can also help delay the progression of some diseases.

Methods:
In this study, 43 phytochemical constituents from four medicinal plants were tested for
their binding affinity to the influential VEGFR2 target of diabetic retinopathy. The study used a
computational approach, in silico molecular docking study, structure-based drug design approach,
MSD (Molecular Dynamic Simulation analysis), in silico ADME(T) studies.

Results:
The study reported that all phytochemical constituents displayed good to the highest binding
affinity than the standard ruboxistaurin. Six phytochemical constituents, namely terchebulin,
pedunculagin, punicalagin, punicalin, casuariniane, and chebulagic acid, exhibited equipotent to
higher activity than the standard. These constituents displayed conventional hydrogen bonds, pialkyl,
and pi-cation interactions to achieve their high binding affinity. The highest binding scores
were chosen for analysis using MSD, ensuring stability of the ligand-protein complex. Pharmacodynamic
and pharmacokinetic properties were evaluated, and their safety profile was validated.

Conclusion:
This in silico screening study suggests that active phytomolecules present in medicinal
plants may inhibit the VEGFR2 target. The best-docked compounds, possessing drug-like properties,
can be used to develop potential inhibitors against DR or to mitigate its severity.
Multifaceted Role of Tiliroside in Inflammatory Pathways: Mechanisms and Prospects
Authors: Kaur Gurjeet , Kaur Jasleen , Goyal Jayant , Vaid Lavish , Singh Thakur Gurjeet , Singh Randhir , Devi Sushma 
Published: October 2024

Abstract:
Tiliroside, a natural polyphenolic compound found in several plant sources, has garnered
attention for its potential to mitigate inflammation and its associated diseases. The current
review explores the multifaceted functions of Tiliroside in inflammation-related diseases, delving
into the underlying mechanisms and prospects for therapeutic applications. Tiliroside exerts
its anti-inflammatory effects through a variety of mechanisms, such as the inhibition
of inflammatory mediators’ cytokines and chemokines, as well as the suppression of nuclear
factor-kappa B (NF-κB) signaling pathways. Additionally, it demonstrates potent antioxidant
properties, which further contribute to its anti-inflammatory activity by reducing oxidative
stress. In preclinical studies, Tiliroside has shown promising results in ameliorating inflammation
in conditions like rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis.
Furthermore, Tiliroside's ability to modulate immune responses and stimulate tissue regeneration
contributes to its potential as a multimodal agent in treating inflammation-associated disorders.
In conclusion, Tiliroside emerges as a promising natural compound with a multifaceted
role in inflammation-related diseases with understanding the underlying mechanisms of its therapeutic
prospects may pave the way for novel treatments.
Construction and Application of a Private 5G Standalone Medical Network in a Smart Health Environment: Exploratory Practice From China
Authors: Chen Baozhan , Shi Xiaobing , Feng Tianyi , Jiang Shuai , Zhai Yunkai , Ren Mingxing , Liu Dongqing , Wang Chengzeng , Gao Jinghong 
Published: October 2024

Background
To date, the differentiated requirements for network performance in various health care service scenarios—within, outside, and between hospitals—remain a key challenge that restricts the development and implementation of digital medical services.

Objective
This study aims to construct and implement a private 5G (the 5th generation mobile communication technology) standalone (SA) medical network in a smart health environment to meet the diverse needs of various medical services.

Methods
Based on an analysis of network differentiation requirements in medical applications, the system architecture and functional positioning of the proposed private 5G SA medical network are designed and implemented. The system architecture includes the development of exclusive and preferential channels for medical use, as well as an ordinary user channel. A 3-layer network function architecture is designed, encompassing resource, control, and intelligent operation layers to facilitate management arrangements and provide network open services. Core technologies, including edge cloud collaboration; service awareness; and slicing of access, bearer, and core networks, are employed in the construction and application of the 5G SA network.

Results
The construction of the private 5G SA medical network primarily involves system architecture, standards, and security measures. The system, featuring exclusive, preferential, and common channels, supports a variety of medical applications. Relevant standards are adhered to in order to ensure the interaction and sharing of medical service information. Security is achieved through mechanisms such as authentication, abnormal behavior analysis, and dynamic access control. Three typical medical applications that rely on the 5G network in intrahospital, interhospital, and out-of-hospital scenarios—namely, mobile ward rounds, remote first aid, and remote ultrasound—were conducted. Testing of the 5G-enabled mobile ward rounds showed an average download rate of 790 Mbps and an average upload rate of 91 Mbps. Compared with 4G, the 5G network more effectively meets the diverse requirements of various business applications in prehospital emergency scenarios. For remote ultrasound, the average downlink rate of the 5G network is 4.82 Mbps, and the average uplink rate is 2 Mbps, with an average fluctuation of approximately 8 ms. The bandwidth, performance, and delay of the 5G SA network were also examined and confirmed to be effective.

Conclusions
The proposed 5G SA medical network demonstrates strong performance in typical medical applications. Its construction and application could lead to the development of new medical service models and provide valuable references for the further advancement and implementation of 5G networks in other industries, both in China and globally.
The Place of Gladue in Constitutional Law
Authors: Kerr Lisa 
Published: October 2024

While the Supreme Court of Canada has been a strong defender of the Gladue sentencing framework that it constructed under section 718.2(e) of the Criminal Code, the Court has so far declined to hold directly that the Gladue approach is constitutionally required. A majority decision in Sharma rejected one possible path to the constitutionalization of Gladue by way of section 15 of the Charter. But the Gladue principles have had a significant impact on the section 12 context, where the integration of Gladue into section 12 jurisprudence reveals much about how Gladue works in the everyday world of sentencing courts. Gladue fits well with section 12 because both protect and tolerate a highly discretionary system of sentencing law in which trial judges must be substantially free to respond to the mix of factors before them. In this system, Gladue functions as an epistemic demand but not as an exceptional law of sentencing for Indigenous people. While the Court has repeated that section 718.2(e) is aimed at reducing overrepresentation of Indigenous people in prison, it is simultaneously clear that judges must apply the universal, fundamental principle of proportionality when imposing sentences on Indigenous people. On two specific topics explored in this paper — the impact of imprisonment and the use of personal traits in reasonable hypotheticals — the Gladue approach has become highly consequential to the question of gross disproportionality under section 12 and, more generally, to the viability of mandatory minimums.
Del documento en el derecho romano hacia las herramientas tecnológicas = From the document in roman law towards technological tools
Authors: Juárez Norma Alicia , Peralta Soledad Andrea 
Published: October 2024

Para lograr el objetivo propuesto el trabajo se dividirá en dos partes. En la primera parte se analizará la forma en que se celebraban los actos jurídicos de la época arcaica, principalmente la mancipatio, como el negocio per aes et libram más extendido en su uso; la stipulatio, como contrato verbal que deviene en contrato litteris, la aparición de las formas de testar que admitirán se grabe en tablillas la voluntad del testador, principalmente, la mención del nombre del heredero instituido, la utilización de la marca del testador, sello y firma. La utilización cada vez más frecuente de la escritura y la aparición del encargado de efectuar ese trabajo, el tabelión y luego más modernamente la figura del notario, hacedor por excelencia del documento escriturario. Las disposiciones del Corpus Iuris Civilis consagrando la utilización del documento escrito. En la parte segunda, se analizará el fenómeno de la firma digital como resultado de los adelantos tecnológicos y los pasos previos que concluyen con la sanción de las leyes actuales sobre firma digital y documento electrónico y las disposiciones del Código Civil y Comercial de la Nación a ese respecto.
ABSTRACT: To achieve the objective, the work will be divided into two parts. In the first part, the way in which legal acts ere celebrated in the archaic era will be analyzed, mainly the mancipatio, as the most widespread business per aes et libram in its use; the stipulatio, as a verbal contract that becames a litteris contract, the appearance of the forms of will that wil allow the will of the testator to be recorded on tablets, mainly the mention of the mane of the instituted heir, the use of the testator´s mark, seal and signature. The increasingly frequent use of writing and the appearance of the person in charge of carrying out that work, the tabelion, and then more modernly the figure of the notary, maker par excellence of the written document. The provisions of the Corpus Iuris Civilis enshrining the use of the written document. In the second part, the phenomenon of the digital signature will be analyzed as a result of technological advances and the previous steps that conclude with the sanction of the current laws on digital signature and electronic document and the provisions of the Civil and Commercial Code of the Nation, that respect.
Dynamics of organisational attractiveness and perceived attributes: Evidence from Turkish construction sector
Authors: Pehlivanli Edib Ali 
Published: October 2024

Abstract
This study explores the relationship between organisational attractiveness and perceived organisational attributes, focusing on how job seekers’ urgency and long-term orientation (LTO) affect their perceptions, specifically within the construction sector. Using data from 270 participants in Central Anatolia’s employment agencies, the research employs analysis of variance (ANOVA) and regression analyses to understand how these motivational states impact views of potential employers. Findings indicate that organisational attractiveness significantly influences perceived organisational attributes, consistent with theories positioning it as crucial in employment decisions. A notable moderation effect emerges with job search urgency: while urgency heightens perceptions of organisational attractiveness and attributes, it weakens the impact of organisational attractiveness on perceived attributes when urgency is high. This suggests that urgent job seekers prioritise immediate benefits like job availability over long-term qualities. Conversely, LTO does not significantly moderate the relationship, implying that immediate concerns overshadow potential long-term engagement for job seekers. These insights suggest tailored recruitment strategies: employers aiming to attract urgent job seekers should highlight immediate benefits and support, while those targeting non-urgent seekers should emphasise stability and long-term career opportunities. This study enhances the understanding of employment dynamics, emphasising the need for nuanced recruitment approaches that consider job seekers’ varying priorities and urgencies. It contributes to human resource management discourse by showing how urgency and orientation influence employment preferences and decisions, guiding more effective recruitment practices. These findings have practical implications for the construction industry, suggesting that addressing job seekers’ immediate and long-term needs can enhance recruitment effectiveness in a sector often perceived as less attractive due to challenging work conditions.
Capillaroscopic Insights: Exploring the Connection Between Microvascular Changes and Pulmonary Manifestations in Systemic Sclerosis
Authors: Palici Camelia , Vreju Ananu Florentin , Biţă Cristina Elena , Dinescu Ștefan Cristian , Florescu Alesandra , Muşetescu Anca Emanuela , Barbulescu Andreea Lili , Ciurea Paulina Lucia 
Published: October 2024

Abstract
Background: Systemic sclerosis (SSc) is a complex connective tissue disease characterized by microangiopathy, immune dysregulation, and fibrosis. Early detection of microvascular abnormalities using nailfold videocapillaroscopy (NVC) is crucial in assessing disease progression and associated disease’s involvement such as interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH).
Objective: This study aims to explore the relationships correlation between NVC patterns, clinical manifestations, and systemic complications in SSc.
Methods: We analyzed the data of 63 patients, predominantly female (95%), with a mean age of 49 years and an average disease duration of 42 months. Patients were categorized into early, active, and late patterns based on NVC findings. Clinical features, including digital ulcers (DU), ILD, and PAH, were assessed. Pearson correlation analyses were performed to evaluate the relationships between capillary loss, neoangiogenesis, ILD, and PAH.
Results: The early pattern group (mean mRSS 2.36) exhibited minimal microvascular damage and systemic involvement, with no DUs. In the active pattern group (mean mRSS 10.40), 34.38% had diffuse cutaneous SSc (dcSSc), with 15.63% presenting DUs, 65.63% ILD, and 37.5% PAH. The late pattern group (mean mRSS 18.00) showed the most severe disease, with 80% having DUs, 70% dcSSc, 90% ILD, and 70% PAH. Pearson correlation analyses revealed strong correlations between capillary loss and ILD (r = 0.7255) and PAH (r = 0.6369). A moderate correlation was found between neoangiogenesis and PAH (r = 0.5592).
Conclusion: The study demonstrates that progressive microvascular damage in SSc, as visualized by NVC, correlates strongly with the severity of systemic complications. Early detection of capillary loss and neoangiogenesis using NVC is critical for timely interventions, which could improve patient outcomes by mitigating the progression of ILD and PAH.
Bedeutung und Entwicklung der Produktivität
Authors: Weyerstraß Klaus 
Published: October 2024

Abstract
Labour productivity is an important determinant of competitiveness. for competitiveness. It is significantly influenced by the total factor productivity. In Austria, as in most other industrialized countries, growth in labour productivity and total factor productivity has considerably in recent decades. The starting points for reviving productivity growth are the promotion of investment and research and development as well as strengthening competition and the risk capital market.
Patterns of Psychophysiological Responses to Multifactor Stimuli Tied to Multiple Intelligences and Personality Vices
Authors: В.А. Минкин , В.А. Акимов , Е.С. Щелканова 
Published: October 2024

Исследована статистика результатов тестирования психофизиологической реакции (ПФР) 1002 испытуемых программой Профайлер+ при предъявлении 48 коротких 5-секундных многофакторных стимулов, имеющих смысловую привязку к способностям (множественным интеллектам) и порокам личности. Установлено, что корреляция между усредненными ПФР на стимулы способностей и пороков логарифмически увеличивается до значения (r = 0,795) при максимальном количестве суммируемых ПФР. Проанализирована корреляция между ПФР при последовательном предъявлении стимулов как функция времени между предъявляемыми стимулами и реализованы рекомендации по уменьшению взаимного влияния стимулов (эффект Кулешова) на получаемый психофизиологический профиль. Приведены диаграммы рассеянья разности значимых и незначимых ПФР на стимулы способностей и пороков. Определены закономерности и установлены границы близких к нормальному распределений трех интегральных психофизиологических показателей: Активация нервной системы (A), эмоциональный Баланс (B) и Сознательная искренность (C), которые предлагается использовать как индикаторы нормы и отклонений характеристик личности. Приведены формулы расчета интегральных психофизиологических показателей, измеренных с помощью технологии виброизображения, и дано обоснование их применения для оценки девиантного поведения.
The statistics of the psychophysiological responses (PPR) of 1002 subjects testing by Blitz Judgment program based on presentation of 48 short 5-second multifactor stimuli having semantic link to multiple intelligences (MI) and personality vices (PV) was studied. It has been established that the correlation between the averaged PPRs for MI and PV stimuli increases logarithmic to the value (r = 0.795) with the maximum number of summed PPR. The correlation between PPRs during sequential presentation of stimuli as the time function between presented stimuli is analyzed and recommendations were realized to reduce the mutual influence of stimuli (Kuleshov effect) on the resulting psychophysiological profile. Scatter diagrams of the difference between significant and insignificant PPR for the stimuli of MI and PV are presented. Patterns and boundaries have been established for close to normal distributions of three integral psychophysiological indicators: the Activation of nervous system (A), the emotional Balance (B) and the Conscious sincerity (C), used as indicators of norms and deviations of personality traits. Equations for calculating integral psychophysiological indicators using vibraimage technology are given and justification for their use in assessing deviant behavior is given.