bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Until Death Do We (Queers) Part”: (Queer) Biblical Interpretation, (Invented) Truth, and Presumption in Controversies Concerning Biblical Characters’ Sexualities
Authors: Miller Joshua H. 
Published: May 2017

Abstract
This article analyzes the arguments for and against the existence of queer characters in the Bible. Situated in a larger debate about whether or not scripture condemns queerness, public arguments proclaiming the existence of queer biblical characters remain underexplored by queer rhetorical scholars. This article argues that the argumentative strategies made by people in response to the possibility of queer biblical characters mirrors how people respond to dominant beliefs that suggest scripture condemns queerness. As such, arguments about biblical characters’ sexualities undermine a heteronormative presumption in favor of readings of scripture that condemn queerness.
The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism
Authors: Kleinberger Gernot , Brendel Matthias , Mracsko Eva , Wefers Benedikt , Groeneweg Linda , Xiang Xianyuan , Focke Carola , Deußing Maximilian , Suárez‐Calvet Marc , Mazaheri Fargol , Parhizkar Samira , Pettkus Nadine , Wurst Wolfgang , Feederle Regina , Bartenstein Peter , Mueggler Thomas , Arzberger Thomas , Knuesel Irene , Rominger Axel , Haass Christian 
Published: May 2017

AbstractGenetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk for several neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia (FTD). Homozygous TREM2 missense mutations, such as p.T66M, lead to the FTD‐like syndrome, but how they cause pathology is unknown. Using CRISPR/Cas9 genome editing, we generated a knock‐in mouse model for the disease‐associated Trem2 p.T66M mutation. Consistent with a loss‐of‐function mutation, we observe an intracellular accumulation of immature mutant Trem2 and reduced generation of soluble Trem2 similar to patients with the homozygous p.T66M mutation. Trem2 p.T66M knock‐in mice show delayed resolution of inflammation upon in vivo lipopolysaccharide stimulation and cultured macrophages display significantly reduced phagocytic activity. Immunohistochemistry together with in vivo TSPO small animal positron emission tomography (μPET) demonstrates an age‐dependent reduction in microglial activity. Surprisingly, perfusion magnetic resonance imaging and FDG‐μPET imaging reveal a significant reduction in cerebral blood flow and brain glucose metabolism. Thus, we demonstrate that a TREM2 loss‐of‐function mutation causes brain‐wide metabolic alterations pointing toward a possible function of microglia in regulating brain glucose metabolism.
Tique e toc na escola: mais que um problema de saúde, uma questão social e pedagógica
Authors: Mamede Walner 
Published: May 2017

O transtorno do tique é um problema que envolve eventos tônicos ou clônicos corporais ou vocais, que vai além de uma abordagem patológica, em direção a uma necessária abordagem social e educacional. Sua ocorrência pode estar ou não associada com distúrbios psicológicos, caracterizando um transtorno mais complexo denominado Síndrome de Tourette. Em qualquer caso tratado, ele se constitui como um problema a ser enfrentado na escola, seja na perspectiva da aprendizagem, seja na da socialização. Por meio de uma incursão na literatura disponível sobre o tema, o presente artigo tem como principal objetivo a apresentação desse mal, tão pouco conhecido entre os profissionais da Educação, esclarecendo seus sintomas e hipóteses etiológicas e sugerindo estratégias e direções que podem mitigar o sofrimento do aluno em seu processo de escolarização.
A deletion mutation in nfxB of in vitro-induced moxifloxacin-resistant Pseudomonas aeruginosa confers multidrug resistance
Authors: Thai Van Chi , Pham Hoang Vy , Nguyen Duc Nhat Minh , Lambert Peter , Nguyen Thi Thu Hoai 
Published: May 2017

The modulation of efflux pump functions under fluoroquinolone (FQ) exposure is of great concern as it could result in occurrence of multidrug-resistant (MDR) bacterial strains. In this study, MDR mechanism in Pseudomonas aeruginosa induced via moxifloxacin (MOX) pressure was investigated. After serial MOX [concentration of 0.5 × the minimum inhibitory concentration (MIC)] exposure, the fully susceptible P. aeruginosa ATCC 9027 strain has increased its MIC not only toward MOX (1→128 mg/L) but also to other antibiotics. Furthermore, this MOX-exposed strain did not revert to antibiotic-sensitive phenotype when being cultured in antibiotic-free medium for 12 days. No mutation was observed for FQ-target (gyrA and parC) or most investigated efflux regulatory genes (mexT, mexR, and nalC) except nfxB in which a 100-bp deletion was found. This associated with the elevated expression of multidrug efflux pump operon (mexCD-oprJ) which could directly result in MDR phenotype.
Traumás asphyxia maradandó látásvesztéssel
Authors: Kántor Tibor , Grigorescu Bianca , Popescu Gabriel , Ferencz Attila , Nagy Örs , Jung János , Gergely István 
Published: May 2017

Abstract: Traumatic asphyxia is a rare condition that occurs after compressive thoracoabdominal trauma, which is characterized by subconjunctival hemorrhage, cervicofacial cyanosis, edema and petechiae. Serious life-threatening thoracic and abdominal injuries may coexist. After conservatory treatment in most cases complete recovery is achieved, but in isolated cases permanent neurological lesions may occur. We present the case of the 39-year-old male patient who suffered a compressive thoracoabdominal trauma. The physical examination showed the characteristic “ecchymotic mask”. After surgical treatment of the abdominal injuries and intensive therapy the patient was discharged with permanent vision loss. The high retrograde venous pressure in the head and neck may be associated with neuronal ischemia, which can lead to irreversible optic nerve atrophy. It is therefore important to carry out an early, routine and complete ophtalmologic examination, especially in the intubated and poorly cooperative patients. Orv Hetil. 2017; 158(22): 864–868.
„Centrális véna – nővér módra?” Perifériáról bevezetett centrális vénás kanülökkel szerzett tapasztalataink
Authors: Kollár Gábor , Alizadeh Hussain , Gulyás Erna 
Published: May 2017

Abstract: What is PICC line insertion? The PICC is a soft, flexible catheter which is made of polyurethane or silicone, and is inserted via an upper or lower extremity peripheral vein into superior or inferior vena cava. The origin of PICC line dates back to the early 1950s. Since the introduction of the PICC catheter, this method of venous catheterization has gone through many changes as regards the technique of insertion or the type of catheter used. Despite the routine use of PICC line worldwide, little progress has been made in its use in Hungary. In this short review we will briefly summarise the use of PICC line, its indications, advantages, disadvantages, and on complementary devices which are necessary during the procedure. We discuss our experience in insertion of PICC line at Pécs University, where the procedure is solely done by a certified registered nurse. We hope that with continuous progression of nurse competency, this procedure will be implemented at a higher scale in Hungary. Orv Hetil. 2017; 158(22): 856–863.
MICROSTRUCTURE FEATURES OF CHROME-NICKEL COATING WELDED WITH FILLER WIRE PL AN-111 WITH A 50% OVERLAP
Authors: Belik A. G. , Efremenko B. V. , Makurov S. L. 
Published: May 2017

Purpose. The paper involves investigation of microstructure features of the coating welded with filler wire PL AN-111 with a 50% beads overlap. Methodology. Wear-resistant layer was formed by means of electric arc deposit welding using filler wire PL AN-111 on the plate from steel 09G2S. Deposit welding was conducted under the following parameters: welding current is of 650-750 A; arc voltage is of 30-34 V; welding speed is of 32 m/h. Microstructure was researched with application of optical microscopies “Neophot-21”, “Nikon Eclipse M200” and electron scanning microscopy JEOL JSM-6510 LV. Microhardness of structural constituentswas measuredwithtesterFM-300 (Future-Tech) under loading of 10-50 g. Findings. It is shown that the overlap of the beads leads to the formation of inhomogeneous microstructure in the cross section that varies by zones from free-carbide austenite to hypereutectic microstructure with primary chromium carbides. The analysis of the microhardness of the structural constituents in various coating areas was carried out. It was found that hardness of austenite, carbide eutectic and carbides M7C3 varies in coatings in the range of 3 100-3 850 МPа, 4 100-6 800 МPа and 12 100-15 100 МPа, accordingly. Originality. Authors determined that Cr-Ni coating comprises substantially austenitic-carbide eutectic with different density and thickness of carbide fibers within eutectic colonies. Along the border “base/coating” a single-phase austenitic layer lies which turns into a layer with a hypoeutectic structure. In the heat affected zone from beads fusion austenite disintegration with the granular carbides formation was recorded. This leads to decreasing of matrix corrosion resistance due to chromium depletion. Above the zone of beads fusion, the coating has a hypereutectic structure with the presence of large primary chromium carbides. Practical value. It is shown that deposit welding with filler wire PL AN-111 with a 50% overlap of beads results in a coarsening of the structure due to formation of a hypereutectic structure comprising in the presence of large primary chromium carbides with lower microhardness.
Complete Responses to Mitotane in Metastatic Adrenocortical Carcinoma—A New Look at an Old Drug
Authors: Reidy-Lagunes Diane L. , Lung Betty , Untch Brian R. , Raj Nitya , Hrabovsky Anastasia , Kelly Ciara , Gerst Scott , Katz Seth , Kampel Lewis , Chou Joanne , Gopalan Anu , Saltz Leonard B. 
Published: May 2017

Abstract

Purpose
Based largely on reports that predate modern reporting standards, mitotane has been considered a systemic treatment option for both hormone control and antitumor control of metastatic adrenocortical cancer (ACC), although the therapeutic window is narrow.

Methods
We searched electronic medical records to identify patients with metastatic ACC treated and prescribed single-agent mitotane at Memorial Sloan Kettering Cancer Center from March 15, 1989–September 18, 2015. Reference radiologists reviewed all imaging and determined efficacy according to Response Evaluation Criteria in Solid Tumors 1.1. Patient demographics, toxicities, and treatment outcomes were reviewed. Next-generation sequencing was performed in selected cases.

Results
Thirty-six patients were identified. The mean age was 54 and 50% had functional tumors. Grade 3 or greater toxicities were documented in 16 out of 36 patients (44%) and 17% had documented long term adrenal insufficiency. Progression of the disease as the best response occurred in 30 out of 36 patients (83%) and one patient (3%) experienced clinical progression. Three patients achieved a complete response (CR) (8%), one patient achieved a partial response (3%), and one patient (3%) had stable disease after slow disease progression prior to initiation of therapy (durable for 6 months). All responders had nonfunctional tumors. Next-generation sequencing in two of the three CR patients was performed and failed to identify any novel alterations.

Conclusion
In this retrospective series, mitotane had a low response rate and low tumor control rate; however, a disproportionately high complete response rate suggested it should be used in selected individuals. Adrenal insufficiency is common with mitotane use and aggressive treatment with steroid supplementation should be considered when appropriate to avoid excess toxicities. Biomarkers are desperately needed to further define this disease.
Predictors of Disruptions in Breast Cancer Care for Individuals with Schizophrenia
Authors: Irwin Kelly E. , Park Elyse R. , Shin Jennifer A. , Fields Lauren E. , Jacobs Jamie M. , Greer Joseph A. , Taylor John B. , Taghian Alphonse G. , Freudenreich Oliver , Ryan David P. , Pirl William F. 
Published: May 2017

AbstractBackgroundPatients with schizophrenia experience markedly increased breast cancer mortality, yet reasons for this disparity are poorly understood. We sought to characterize disruptions in breast cancer care for patients with schizophrenia and identify modifiable predictors of those disruptions.Materials and MethodsWe performed a medical record review of 95 patients with schizophrenia and breast cancer treated at an academic cancer center between 1993 and 2015. We defined cancer care disruptions as processes that interfere with guideline-concordant cancer care, including delays to diagnosis or treatment, deviations from stage-appropriate treatment, and interruptions in treatment. We hypothesized that lack of psychiatric treatment at cancer diagnosis would be associated with care disruptions.ResultsHalf of patients with schizophrenia experienced at least one breast cancer care disruption. Deviations in stage-appropriate treatment were associated with breast cancer recurrence at 5 years (p = .045). Patients without a documented psychiatrist experienced more delays (p = .016), without documented antipsychotic medication experienced more deviations (p = .007), and with psychiatric hospitalizations after cancer diagnosis experienced more interruptions (p &lt; .0001). Independent of stage, age, and documented primary care physician, lack of documented antipsychotic medication (odds ratio [OR] = 4.97, 95% confidence interval [CI] = 1.90, 12.98) and psychiatric care (OR = 4.56, 95% CI = 1.37, 15.15) predicted cancer care disruptions.ConclusionDisruptions in breast cancer care are common for patients with schizophrenia and are associated with adverse outcomes, including cancer recurrence. Access to psychiatric treatment at cancer diagnosis may protect against critical disruptions in cancer care for this underserved population.
PERCEPÇÃO, CONHECIMENTO E PRÁTICA DE PEDIATRAS QUANTO AO POSICIONAMENTO DO LACTENTE E O DESENVOLVIMENTO MOTOR
Authors: Pinto Priscilla Avelino Ferreira , Falci Denise Mourão , Morais Rosane 
Published: May 2017

Introdução: O desenvolvimento infantil é uma temática de interesse pediátrico multidisciplinar sendo importante saber qual a percepção de diferentes profissionais envolvidos, considerando que intervenções e orientações por vezes, são necessárias. Objetivo: verificar a percepção, conhecimento e prática de pediatras quanto ao posicionamento do lactente e o seu desenvolvimento motor. Método: Estudo qualitativo, do tipo estudo de caso, realizado em uma cidade no interior de Minas Gerais, Brasil. Para a seleção dos participantes da pesquisa utilizou-se a técnica de “amostragem por variedade de tipo”, seis pediatras participaram do estudo respondendo uma entrevista individual e semiestruturada, no período de setembro a dezembro de 2014. Os dados foram analisados por “análise de conteúdo” e foram identificadas quatro categorias: orientação quanto ao decúbito do lactente para dormir; percepção do desenvolvimento motor de lactentes após campanha de “supino para dormir”; conhecimento e práticas sobre o desenvolvimento motor dos lactentes; prescrição de prono para o lactente enquanto acordado. Resultados: Alguns pediatras recomendam o supino e outros o decúbito lateral para dormir, a última posição principalmente em casos de refluxo gastresofágico. Indicam o prono quando acordado principalmente para o desenvolvimento do controle cervical e as orientações em relação ao prono foram variadas. Conclusões: Os pediatras entrevistados contraindicam o prono, mas principalmente recomendam o decúbito lateral, seguido de supino para dormir. Eles não perceberam, em sua prática clínica, atraso do desenvolvimento motor dos lactentes em decorrência da recomendação de supino para dormir, pelo contrário, consideram as crianças cada vez mais adiantadas em seus marcos do desenvolvimento.
PRACTICAL ASPECTS ABOUT TRACHEOSTOMY CANNULA: A SYSTEMATIC REVIEW
Authors: Tavares Aline Cristina , Machado Luzimar Martins 
Published: May 2017

Context: Since the first sterling tracheostomy cannula was developed, in the late 1800's, and some modernization has occurred, there have been several reports on flaws surrounding their care. Objetive: Provide a comprehensive review about tracheostomy cannulas. Methods: A systematic search of the PubMed and Medline databases was conducted on closed drainage system using the following keyword combination: tracheostomy AND cannula. Results: From eight hundred eight-three articles retrieved after our preliminary search, 17 articles were chosen for final analysis. Representative schemes were drawn to better understanding of the three distinguished materials types and ten different components (faceplate, cannula, radiopaque line in the cannula, inner cannula, universal hub 15mm, pressure line, pilot balloon, cuff, subglottic aspiration system, obturator), as well as their concerns. Conclusions: Knowing and understanding tracheostomy cannulas. particularities may imply in a better approach to the patients, and in minimizing institutional costs.
FATORES BIOMECÂNICOS RELACIONADOS À POSTURA EM BAILARINOS: UMA REVISÃO INTEGRATIVA
Authors: Costa Nicole Nunes Souza , De Castro Érico Vinícius Santana , De Jesus Iracema Almeida , Trippo Karen Valadares 
Published: May 2017

Introdução: O ballet clássico é uma das atividades físicas mais procuradas com o objetivo de obter boa postura. Entretanto, a exigência da organização das contrações musculares e adaptações articulares durante os movimentos do ballet, podem gerar alterações biomecânicas relacionadas à postura desse indivíduo. Objetivo: Realizar uma revisão de literatura do tipo integrativa sobre os principais fatores biomecânicos relacionados à postura em praticantes do ballet clássico. Materiais e métodos: Foi realizada, no período entre janeiro a agosto de 2016, uma busca nas bases de dados eletrônicas Pubmed, Scientific Eletronic Library Online (SciELO), Biblioteca Virtual em Saúde (BVS), Physiotherapy Evidence Database (PEDro), Periódicos Capes e Google Scholar. Resultados: Foram encontrados um total de 673 artigos científicos, sendo selecionados 27 publicações após avaliação dos critérios de inclusão e exclusão. Os artigos pesquisados encontraram associação da postura de bailarinos com o centro de oscilação do corpo, cinestesia, controle do equilíbrio postural; sendo que as mudanças biomecânicas foram justificadas pelo longo período da prática dessa modalidade. Conclusão: Os bailarinos apresentaram menor oscilação do corpo em menor base de apoio, boa correspondência cinestésica para membros superiores, controle do equilíbrio postural por melhor resposta neuromuscular especialmente de olhos abertos e alterações posturais na coluna vertebral e membros inferiores.
AN EVALUATION OF SELECTED MOROCCAN ELT TEXTBOOKS: A STANDARDS-BASED APPROACH PERSPECTIVE
Authors: Bouzid Hassan Ait 
Published: May 2017

Standards-Based Approach to textbook evaluation has been blooming in recent decades. Nevertheless, this practice has received very little attention in Morocco. The present study aims to bridge a gap in the literature of the Moroccan context by investigating the extent to which three locally designed ELT textbooks conform to the theoretical principles of the Standards-Based Approach which defines the teaching of English as a foreign language in the country (Ministry of National Education, 2007). Its objective is to examine whether and how these textbooks present contents that enable learners to meet the content standards included in the goal areas of Communications, Cultures, Connections and Comparisons. The study is informed by the theoretical framework of the Standards-Based Approach. It adopts a mixed-methods design that uses content analysis as a mixed data analysis method combining both quantitative and qualitative techniques. The findings reveal a number of shortcomings relevant to the representation of the content standards as several standards are not sufficiently addressed in the activities included in these textbooks. Eventually, some suggestions are addressed to policy makers, textbook designers and teachers to overcome the identified problems in current and future textbooks. The study is expected to sensitize ELT practitioners about the viability of using textbook evaluation in boosting both the quality of ELT textbooks and the quality of the teaching learning outcomes.
Recursos Educacionais Abertos: Acesso Gratuito ao Conhecimento?
Authors: Mazzardo Mara Denize , Ferreira Nobre Ana Maria , Mallmann Elena Maria 
Published: May 2017

Neste artigo, destacamos o potencial dos recursos educacionais abertos (REA) para aumentar o acesso ao conhecimento e os desafios dos professores para adaptar (revisar, alterar) esses recursos. A investigação está sendo realizada por meio dos procedimentos metodológicos do Design-Based Research, com um grupo de professores do ensino médio participantes de um small open online course. O objetivo do curso é proporcionar conhecimentos sobre REA, os quais possibilitem a integração deles nos materiais e nas práticas didáticas. Neste trabalho, destaca-se a adaptação de REA. Os dados e análises preliminares sinalizam que a adaptação de REA é uma atividade que demanda dos professores conhecimentos sobre as licenças abertas, os direitos autorais, os repositórios, afluência tecnológico-pedagógica e os conhecimentos para redistribuir os REA adaptados. Uma das dificuldades foi encontrar REA para o ensino médio com licença que permitisse aprodução de obra derivada Palavras-chave: Acesso ao conhecimento, Recursos educacionais abertos,Formação de professores, Adaptação de recursos educacionais abertos. Open Educational Resources: free access to knowledge? AbstractIn this article we highlight the potential of Open Educational Resources (OER)to increase access to knowledge and the challenges of teachers to adapt these resources. Research had being carried out through methodological procedures of Design-Based Research, with a group of high school teachers who had participated in a Small Open Online Course. The aim of the course is to provide knowled ge about OER, which makes possible its integration in materials and teaching practices. Thiswork emphasizes the adaptation of OER. Data and preliminary analyzes indicate that OER adaptation is an activity that requires teachers knowledge of open licenses, copyrights, repositories, technological and pedagogical fluency, knowled ge to redistribute adapted OER. One of the difficulties was to find OER to high school purporse with license that allows the production of derivative work. Keywords: Access to knowledge, Open rducational resources, Teacher training, Adaptation of open educational resources.