bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bivalirudin Inhibits Thrombin-Mediated Tissue Factor Expression in Human Endothelial Cells
Authors: Cirillo Plinio , Pellegrino Grazia , Conte Stefano , Cimmino Giovanni , Barra Giusi , De Palma Raffaele , Trimarco Bruno 
Published: July 2017

<p><span style="font-family: Times;"><span style="font-size: medium;">Thrombosis is the main pathophysiological mechanism in Acute Coronary Syndromes (ACS), and involves the activation of platelets and of Tissue Factor (TF)-dependent extrinsic coagulation pathway. TF-mRNA and antigen are detectable in the adventitia of normal vessels. On the contrary, little TF immunoreactivity is measurable in the smooth muscle cells of uninjured vessels and unperturbed endothelial cells, being in contact with circulating blood, usually do not express TF activity. However, several stimuli are able to induce TF in endothelial cells, including thrombin. Thus in an acute "scenario", thrombin might be responsible for creating a prothombotic milieau. Bivalirudin (BIVA) is a synthetic, reversible direct thrombin inhibitor actually considered a valuable alternative to heparins in patients who need anticoagulation in the setting of ACS and percutaneous coronary intervention to avoid acute thrombotic events. In the present study we have investigated whether BIVA, by inhibiting thrombin, might have effects on TF expression and procoagulant activity in endothelial cells. Human Umbilical Endothelial Cells (HUVEC) were stimulated with thrombin or with the activated coagulation factors FVIIa/FXa for 2 hrs to evaluate TF-mRNA transcription by real-time PCR and for 6 hrs to measure TF expression/activity </span><span style="font-size: medium;">on cell surface by FACs analysis and procoagulant activity. In additional experiments HUVEC were </span><span style="font-size: medium;"> </span><span style="font-size: medium;">pre-treated with BIVA for 1 hr before being stimulated and processed as above. Thrombin induced TF-mRNA transcription as well TF expression/activity on HUVEC shifting them to a procoagulant phenotype. On the contrary, the activated coagulation factors FVIIa/FXa did not affect TF expression/activity, indicating that thrombin plays a pivotal role in mediating this phenomenon. BIVA was able to prevent these thrombin deleterious effects. Data of the present study, although in vitro, suggest that BIVA, in the context of ACS, might significantly reduce thrombogenicity not only by acting as direct thrombin inhibitor but through its effects on TF expression/activity too.</span><span style="font-size: medium;"> </span></span></p>
Coronary Artery Rupture After Bioresorbable Vascular Scaffold Implantation Resolved with Graft Stent: Optical Coherence Tomography Assessment
Authors: Camacho Freire Santiago Jesus , Cardenal Piris Rosa , Roa Garrido Jessica , Gomez Menchero Antonio Enrique , Leon Jimenez Javier , Diaz Fernandez Jose Francisco 
Published: July 2017

Coronary artery perforation (CAP) is an infrequent and life-threatening complication of percutaneous coronary intervention (PCI). We report a 52-year-old male admited with NSTEMI. During percutaneous coronary intervention on left anterior descending artery with bioresorbable vascular scaffolds the patient suffered a type III coronary artery perforation and pericardiocentesis and graft stent implantation was needed. To the best of our knowleadge this is the first case reported of stent graft assessment by optical coherence tomography (OCT) after coronary artery perforation with a bioabsorbable vascular scaffold (BVS). In the acute phase by OCT, the backscattering does not allow see though the graft stent, nevertheless in the follow up it does. We describe a early positive remodeling on the BVS segment.
The Complex Cardiac Atherosclerotic Disorder: The Elusive Role of Genetics and the New Consensus of Systems Biology Approach
Authors: Louridas George , Lourida Katerina 
Published: July 2017

<p>The present technological status of genetics and genomics or the genome-wide association studies (GWAS) are insufficient to explain complex diseases like atherosclerosis and coronary artery disease (CAD). It appears that the genetic risk variants of atherosclerosis are activated concurrently with functionally active specific environmental risk factors. With the systems biology methodological approach the atherosclerotic process and CAD are better explained and studied as a unified entity with significant clinical consequences.</p><p>Systems biology is an alternative approach for the study of atherosclerosis and CAD. With the systems biology approach the follow-up of the atherosclerotic process requires four conceptual areas of study: 1) the two potential directions, the bottom-up direction (functional composition from genes to phenotypes) and the top-down direction (functional decomposition from phenotypes to genes); 2) the four disciplines or levels of complexity: the genomic, the cellular, the modular and the model (clinical phenotype) level; 3) the concept of network construction; 4) the atherosclerotic plaque development and progression across all levels of complexity.</p><p>The systems biology methodology is holistic in conception. The proposed systems patterns are able to follow up the progressive nature of atherosclerosis and to explain the appearance of the clinical cardiovascular phenotypes. The phenotypes of CAD are integrated clinical wholes that determine through constrains and therapeutic procedures the behavior of the biological parts in the lower levels of complexity. This way of thinking is leading from genomics, through networks, to the mainstay of clinical cardiology. </p>
A study on clinical and pathological correlation of benign breast lesions
Authors: Ramesh Koorapati , Bookya Kishan 
Published: July 2017

Background: Benign breast diseases are common in females among young age group. Most common presentation is painless lump in the breast. Clinical and pathological correlation is essential. Fibroadenoma is the commonest among all other benign breast diseases. The aim was to study the age distribution of benign breast diseases. To study different types of benign breast diseases, their mode of clinical presentation and to correlate with radiological examination, cytology and histopathology of breast diseases.Methods: This was a prospective study conducted in the outpatient department of General Surgery in MGM hospital, Kakatiya Medical College, Warangal over a period of 2 years. A total of 250 patients diagnosed as benign breast diseases on clinical examination were studied and clinical findings were correlated with radiological, cytological and histopathological findings.Results: Patient age ranged 11 to 59 years. Majority of cases 150 (60%) were among 21-30 years. There were 98.8% female patients. Fibroadenomas were 57.6%, fibrocystic disease cases were 13.2%, breast abscesses were 1.6%, Intraductal papilloms 2.0%, simple cysts were 4.8%, Galactoceles 1.8%, Benign phyllodes were 3.6%, proliferative breast disease without atypia were 5.2% and gynaecomastia were 1.2% cases.Conclusions: Benign breast diseases are common among young females. Most of them present as painless mobile breast lump. Breast pain and nipple discharge are the other symptoms. Fibroadenoma is the commonest in our study, followed by fibrocystic changes Clinical diagnosis was correlated with cytology and histopathology.
A study of clinicopathologic spectrum of vesicobullous disorders
Authors: Mittal Heena , Kaur Sukhjot , Garg Bhavna , Sood Neena , Gupta Sunil Kumar , Kaur Sandeep 
Published: July 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Blistering diseases are alarming skin conditions. Autoimmune blistering diseases are a group of bullous disorders characterized by pathogenic antibodies directed at the target antigens in the epidermis or dermoepidermal junction.</span><span lang="EN-IN">The objectives were to study the spectrum of histopathological changes by light microscopy, to evaluate the pattern of direct immunofluorescence (DIF) and to correlate clinical, histopathological features and DIF findings of vesiculobullous lesions of the skin or/and mucosa.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The present study was carried out on 110 skin and/or mucosal biopsies with vesicobullous disorders from July 2013 to June 2016. Detailed clinical history, morphology of lesions, site of involvement and other findings were recorded as per proforma.<strong> </strong>These cases were analysed clinically, histopathologically and on immunofluorescence</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Majority of the patients presented in the age group of 41-50 years (30.9%). The male: female ratio was 1:1.15. Pemphigus vulgaris was the most common vesiculobullous disorder constituting 48.2%, followed by Bullous Pemphigoid constituting 27.3%. Dermatitis herpetiformis constituted 8.3%; Pemphigus foliaceous 3.6%, varicella and Stevens Johnson Syndrome both were observed in 2.7% each. DIF was performed in 81 cases out of which only 72 cases (92.6%) showed positivity. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">DIF is a sensitive tool for distinguishing immune mediated bullous diseases from other vesiculobullous disorders especially in cases which pose a diagnostic dilemma both clinically and histologically. The final diagnosis depends on correlation of clinical, histopathological and immunoflourescence findings.</span></p><p class="abstract"> </p>
TECHNOLOGICAL PLATFORMS FOR SOCIAL ENTREPRENEURSHIP AND COMMUNITY ENGAGEMENT
Authors: Matriano Maria Teresa , Rahman Khan M. Firdouse 
Published: July 2017

Purpose: The objective of the study is to critically examine the concept of Smart data and its influence in creating Social entrepreneurship involving community engagement.
Design/Methodology/Approach: The study involves an in-depth exploratory approach in finding out the technological platform for social entrepreneurship in social engagement.
Findings: Finding the best solution to a problem varies in terms of approach. The term Social Entrepreneurship - sounds vague for some, and the possibilities of its application are virtually limitless, which encompasses a need for boundaries to demarcate its true purpose.
Practical Implications: In today’s modern world, attempting to draw out the context of business techniques with the aid of information technology to solve social problems is being regarded as an emerging approach referred to as social entrepreneurship.
Social Implications: The study confirms the idea of social entrepreneurship is being attributed to its underlying function of fostering community engagement in an attempt to draw out solutions to long-standing social problems.
Originality/Value: The vague understanding of social entrepreneurship requires a more in-depth exploration in which this article intends to achieve.
CONFLITOS EM TORNO DA EMERGÊNCIA DE INOVAÇÕES SÓCIO-ORGANIZACIONAIS: O CASO DO ACORDO DE PESCA NA COMUNIDADE RIBEIRINHA DE PACUÍ DE BAIXO (CAMETÁ-PA)
Authors: Tavares Francinei Bentes , Dias Sara Corrêa 
Published: July 2017

Este artigo visa analisar as modalidades de uso dos recursos pesqueiros, os conflitos socioambientais em torno da pesca e sua relação com os Acordos de Pesca enquanto principal estratégia de conservação do potencial pesqueiro na comunidade de Pacuí de Baixo, no município de Cametá-Pará, construído a partir de uma parceria entre a sociedade civil e o poder público. A análise dos processos organizacionais na busca de alternativas econômicas e de segurança alimentar mostra como os pescadores recompõem seus modos de reprodução através do ordenamento pesqueiro, que também exprime as formas de resistência desses pescadores frente aos impactos contraproducentes oriundos principalmente da construção da Usina Hidrelétrica de Tucuruí- PA. Finalmente, apresenta resultados significativos obtidos a partir de práticas transformadoras que visam o melhor uso, manejo e gestão dos recursos naturais, bem como reflexões das experiências locais que resultaram em benefícios animadores aos camponeses envolvidos na trama social local.
DINÂMICAS TERRITORIAIS SUSTENTÁVEIS INOVADORAS NA AGRICULTURA FAMILIAR: A CONSTRUÇÃO DE CESTAS DE BENS E SERVIÇOS COM IDENTIDADE CULTURAL EM SANTA CATARINA
Authors: Pinheiro Sérgio Leite Guimarães , Simões Mauro De Bonis Almeida , Farias José Giovani , Schlindwein Sandro Luis , Schio Caroline 
Published: July 2017

Buscando inovações em processos de desenvolvimento, uma experiência interinstitucional de Desenvolvimento Territorial Sustentável com Identidade Cultural (DTS IC) em implementação na zona costeira de Santa Catarina (SC) objetiva articular atores sociais e institucionais, setores sócio produtivos, políticas e projetos distintos para promover dinâmicas territoriais sustentáveis e inovadoras, lastreadas pelo patrimônio identitário dos Agricultores Familiares, Pescadores Artesanais e outras comunidades tradicionais de dois territórios-piloto em SC. O referencial teórico desta experiência fundamenta-se naconcepção do “Desenvolvimento Territorial Rural com Identidade Cultural” (DTR IC) cuja metodologia se baseia nos princípios da pesquisa-ação e da abordagem sistêmica de segunda ordem (“soft”). Este artigo sintetiza as estratégias de valorização das comunidades tradicionais, cujos resultados indicam a oportunidade da construção de Cesta de Bens e Serviços Territoriais “enraizados culturalmente”, além de sistemas sócio técnicos e produtivos alternativos ao processo de crescimento convencional baseado no aumento de escala de produtos padronizados (commodities). Por fim, também indica os dilemas e os desafios desta experiência.
A metodologia MESMIS como instrumento de gestão ambiental em agroecossistemas no contexto da Rede CONSAGRO
Authors: Souza Raquel Toledo Modesto de , Martins Sergio Roberto , Verona Luiz Augusto Ferreira 
Published: July 2017

A gestão ambiental de agroecossistemas configura-se como um desafio no contexto daAgricultura Familiar. Enquanto a grande maioria dos estudos tem foco nos processos de produção, tem-se uma lacuna em relação a métodos e ferramentas que auxiliem o agricultor na gestão de seu agroecossistema. Este estudo teve como objetivo propor um roteiro de gestão ambiental para agroecossistemas familiares a partir do método MESMIS de avaliação de sustentabilidade. Inicialmente, apresentaram-se os nexos entre o MESMIS e requisitos de Sistemas de Gestão Ambiental (SGA) conforme a metodologia conhecida como PDCA (Planejamento, Execução, Verificação e Ação). O método MESMIS foi aplicado junto a cinco agroecossistemas, com um olhar direcionado à gestão. Como resultado, foi possível associar às etapas do MESMIS algumas atividades características de SGAs e então compor o roteiro de gestão ambiental. O trabalho está contextualizado na episteme da Rede para Construção de Conhecimento sobre Avaliação de Sustentabilidade de Agroecossistemas (Rede CONSAGRO) e de suas ações junto a agricultores familiares da região Sul do Brasil, cujas atividades são desenvolvidas apoiadas nos princípios da Agroecologia.
Espaço amazônico e estado de sustentabilidade de lógicas familiares de produção: adaptações e uso do MESMIS no caso do estado do Pará
Authors: Silva Luís Mauro Santos , Resque Antonio Gabriel Lima , Feitosa Loyanne Lima , Nogueira Ana Caroline Neris , Carvalho João Paulo Leão de 
Published: July 2017

O estado do Pará se caracteriza como uma região de bioma amazônico, mantendo sua base econômica, sócio ecológica e cultural ligada, fortemente, às atividades extrativas e/ou agroextrativistas. Devido tamanha diversidade e complexidade nas relações entre sociedade e natureza, predominam agroecossistemas familiares com alta complexidade e, portanto, difíceis de serem compreendidos com abordagens disciplinares. Cientes de tal limitação se propôs uma adaptação da metodologia MESMIS para uma leitura sistêmica e comparada de distintas realidades amazônicas, mesmo estando todas no estado do Pará. O objetivo deste trabalho foi estabelecer uma reflexão a respeito dos pontos positivos e negativos da utilização do MESMIS no estado do Pará, em avaliações voltadas a agroecossistemas familiares diversificados e integrados.
Protagonismo, Precarização e Regulação como referências para análise das Políticas e Práticas em Educação do Campo
Authors: Hage Salomão Antônio Mufarrej , Cruz Carlos Renilton 
Published: July 2017

O artigo apresenta uma discussão sobre políticas e práticas em educação do campo,estabelecendo como campo de estudos o Movimento Paraense por uma Educação do Campo e suas estratégias de organização e mobilização pela construção de um projeto popular de desenvolvimento e de educação. Ele foi construído a partir dos resultados de uma pesquisa que estabeleceu três referências como indicadores para a análise da relação que se estabelece entre os movimentos sociais do campo, o Estado, e as universidades. São eles: o protagonismo das populações do campo para inserir na agenda do poder público a educação nos territórios do campo e definir os marcos legais para essa ação; a precarização da vida, do trabalho e das condições de funcionamento das escolas do campo; e a regulação que se institui na relação das populações e movimentos sociais do campo com o Estado e as universidades por ocasião da oferta dos programas educacionais, que resulta na restrição da autonomia dos sujeitos do campo e da universidade na gestão desses programas educacionais.
MASALAH KEMATIAN DALAM SAJAK-SAJAK SUBAGIO SASTROWARDOYO: RELEVANSINYA DENGAN MASALAH KEMANUSIAAN MASA KINI
Authors: Wiranta Wiranta 
Published: July 2017

<p>Tema kematian dalam sajak-sajak Subagio dianggap penting karena selain dapat memberikan pemahaman terhadap makna kematian dalam kese­luruhan sajak-sajak Subagio pada khususnya, juga dapat menjelaskan berbagai hal yang ber­kaitan dengan perkembangan tema-tema puisi Indonesia modern pada umumnya. Esai kecil ini tidak berpretensi menggali seluruh sajak-sajak yang telah ditulis Subagio. Dengan berbagai keterbatasan tulisan ini ingin sekedar menjelaskan mengenai gambaran tema kematian yang teraktualisasi dalam beberapa judul sajak Subagio Sastrowardoyo. Juga tentang gambaran sikap dan pandangan Subagio Sastrowardoyo terhadap masalah kematian dalam sajak-sajaknya.</p><p>Kata Kunci: puisi,kematian, Subagio Sastrawardoyo</p>
On the Origin of I Beams and Quick Analysis on the Structural Efficiency of Hot-rolled Steel Members
Authors: Di Lorenzo Gianmaria , Formisano Antonio , Landolfo Raffaele 
Published: July 2017

Background:In the current paper the origin of steelIbeams has been analysed from historical-technological and structural points of view.Method:First, the way leading to discover the most famous structural member of the modern Steel Engineering has been reconstructed. Later on, parameters of structural efficiency, allowing for a quick numerical evaluation of the effects produced by the rolling process on the semi-finished casting products, have been defined as a function of the difference in terms of weight between the solid billet and the member final shape on the basis of the more or less raw material centrifugation. By using the above mentioned structural efficiency parameters, the design criteria used for development of the European list of sections, with particular reference to IPE and HE profiles, have been comprehended.Result and Conclusion:Finally, the proposed method, if applied to members having the same area, allows defining, without considering local buckling phenomena, the best profile for each performance category of steel members.
Comparing Different Information Levels
Authors: Saint-Mont Uwe 
Published: July 2017

Objective:
Given a sequence of random variables X = X1, X2, . . .suppose the aim is to maximize one’s return by picking a ‘favorable’ Xi. Obviously, the expected payoff crucially depends on the information at hand. An optimally informed person knows all the values Xi = xi and thus receives E(sup Xi).

Method:
We will compare this return to the expected payoffs of a number of gamblers having less information, in particular supi(EXi), the value of the sequence to a person who only knows the random variables’ expected values.
In general, there is a stochastic environment, (F.E. a class of random variables C), and several levels of information. Given some XϵC, an observer possessing information j obtains rj(X). We are going to study ‘information sets’ of the form.

characterizing the advantage of k relative to j. Since such a set measures the additional payoff by virtue of increased information, its analysis yields a number of interesting results, in particular ‘prophet-type’ inequalities.
SOCIAL NETWORK DATA RETRIEVAL USING SEMANTIC TECHNOLOGY
Authors: Srivastav Abhilash , Chauhan Alok 
Published: July 2017

Social network data analysis is an important problem due to proliferation of social network applications, amount of data these applications generate and potential of insight based on this big data. The objective of present work is to propose architecture for a semantic web application to facilitate meaningful social network data analytics as well as answering query about concerned ontology. Proposed technique links, on one hand, tools based on semantic technology provided by social network applications with data analytics tools and on the other hand extends this link to ontology authoring tools for further inference. Results obtained from data analytics tool, results of query on generated ontology and benchmarking of the performance of data analytics tool are shown. It has been observed that a semantic web application utilizing above mentioned tools and technologies is more versatile and flexible and further improvements are possible by applying generic data mining algorithms to the above scenario.
CENTRAL PROCESSING UNIT-GRAPHICS PROCESSING UNIT COMPUTING SCHEME FOR MULTI-OBJECT TRACKING IN SURVEILLANCE
Authors: Rai Ankush , R Jagadeesh Kannan 
Published: July 2017

This research work presents a novel central processing unit-graphics processing unit (CPU-GPU) computing scheme for multiple object trackingduring a surveillance operation. This facilitates nonlinear computational jobs to avail completion of computation in minimal processing time for tracking function. The work is divided into two essential objectives. First is to dynamically divide the processing operations into parallel units, and second is to reduce the communication between CPU-GPU processing units.
SURVEY ON ADVISOR INTELLIGENCE THROUGH PURCHASE PATTERNS AND SALES ANALYTICS
Authors: Pradhan Gayatri K. , Gollapalli Sarath , Janakimeena M , Sp Syedibrahim 
Published: July 2017

In mutual fund, an individual or a firm that is in the business of giving advice about securities to clients is an investment advisor. Investment advisers are individuals or firms that receive compensation for giving advice on investing in stocks, bonds, mutual funds, or exchange-traded funds. Investment advisors manage portfolios of securities. Advisors can use new cognitive and analytics capabilities to better understand their clients and needs and have a stronger ability to deepen relationships with a better portfolio. In this paper, we analyze data points foreach advisor, and distinguish the best prospects, obtain insight into their experience and credentials, and learn about their portfolio, in other words, to recognize the pattern of portfolio of the advisors. Such analysis helps the sales people to sell the fund company products to the suitable advisors based on the nature of the product they want to sell. This is done by investigating what kind of products advisors have been buying, and what kind of products they might be looking for. This helps to increase the sales of the products as sales people will be reaching the appropriate advisors.