bluuebunny/crossref_metadata_2025_split huggingface dataset:
VDAC-Targeted Drugs Affecting Cytoprotection and Mitochondrial Physiology in Cerebrovascular and Cardiovascular Diseases
Authors: Karachitos Andonis , Jordan Joaquin , Kmita Hanna 
Published: May 2017

Background:
Cerebrovascular and cardiovascular diseases are caused by impairment
of the brain and/or heart circulation. Insufficient blood flow results in decreased oxygen
delivery (ischemia), which affects mitochondrial functioning and consequently leads to insufficient
ATP production. The predominant mitochondrial outer membrane protein, the voltagedependent
anion selective channel (VDAC), is considered to be crucial for mitochondrial
functioning. In human mitochondria, as in other vertebrates, three isoforms of VDAC
(VDAC1-VDAC3) are present, and they likely play different roles.

Objective:
In this review, we summarize the available data concerning VDAC involvement in
cardiovascular and cerebrovascular diseases with regard to VDAC isoforms and discuss the use
of possible VDAC-related intervention targets as well as known VDAC-interacting and cytoprotection-
conferring molecules in the treatment of cerebrovascular and cardiovascular diseases.

Method and Results:
The suitable references on disorders defined as cerebrovascular and cardiovascular
diseases as well as VDAC contribution to these conditions were searched using PubMed
and ClinicalTrials.gov databases. The review is based on the 138 carefully selected articles.

Conclusion:
Mitochondrial dysfunction triggered by changes in VDAC properties undoubtedly
contributes to cell death and related diseases, including cerebrovascular and cardiovascular
diseases. Thus, beside diagnostic application, modulation of VDAC activity, including its
isoforms, is thus of great importance for the development of efficient therapeutic interventions.
Moreover, identification of VDAC-interacting molecules that protect against mitochondrial
dysfunction and cell death seems to be of great importance.
The Role of Diet in the Pathogenesis of Cholesterol Gallstones
Authors: Di Ciaula Agostino , Garruti Gabriella , Frühbeck Gema , De Angelis Maria , de Bari Ornella , Wang David Q.-H. , Lammert Frank , Portincasa Piero 
Published: May 2017

:Cholesterol gallstone disease is a major health problem in Westernized countries and depends on a complex interplay between genetic factors, lifestyle and diet, acting on specific pathogenic mechanisms. Overweigh, obesity, dyslipidemia, insulin resistance and altered cholesterol homeostasis have been linked to increased gallstone occurrence, and several studies point to a number of specific nutrients as risk- or protective factors with respect to gallstone formation in humans. There is a rising interest in the identification of common and modifiable dietetic factors that put the patients at risk of gallstones or that are able to prevent gallstone formation and growth. In particular, dietary models characterized by increased energy intake with highly refined sugars and sweet foods, high fructose intake, low fiber contents, high fat, consumption of fast food and low vitamin C intake increase the risk of gallstone formation. On the other hand, high intake of monounsaturated fats and fiber, olive oil and fish (ω-3 fatty acids) consumption, vegetable protein intake, fruit, coffee, moderate alcohol consumption and vitamin C supplementation exert a protective role.:The effect of some confounding factors (e.g., physical activity) cannot be ruled out, but general recommendations about the multiple beneficial effects of diet on cholesterol gallstones must be kept in mind, in particular in groups at high risk of gallstone formation.
Back to the Bench? MEK and ERK Inhibitors for the Treatment of KRAS Mutant Lung Adenocarcinoma
Authors: Kohler Jens , Catalano Marco , Ambrogio Chiara 
Published: May 2017

Background:
Lung cancer accounts for one in five cancer deaths worldwide and mutations
in the gene encoding for the Kirsten rat sarcoma (KRAS) oncoprotein define the largest molecular
subset of non-small cell lung cancer (NSCLC). These tumors are characterized by activated
MAPK signaling, however, no targeted inhibitors of mutant KRAS or of downstream signaling
molecules have yet been approved for routine clinical use.

Objective:
The primary objective of this review is to critically summarize the current developmental
state of MEK and ERK inhibitors in pre-clinical models and in human clinical trials for
KRAS mutant lung cancer particularly in light of the newly emerging concept of immune checkpoint
blockade.

Method:
We performed a Pubmed-based literature search and considered publications from the
fields of basic and translational biomedicinal and biochemistry research, as well as from past and
ongoing human clinical trials (www.clinicaltrials.gov).

Results and Conclusions:
MAPK pathway targeting agents are efficacious in pre-clinical models
but their benefit is limited for patients with KRAS mutant NSCLC due to the lack of predictive
factors, toxicity and the adaptive dynamic kinome reprogramming within the tumor. Overall,
MEK inhibitors have advanced further in clinical development compared to ERK inhibitors. New
treatment strategies as e.g. immune checkpoint blockade are currently revolutionizing the treatment
paradigms and future clinical trials need to show if they replace MAPK targeting strategies
or are used as add-on.
24-Hour Hypoxia and Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis
Authors: Rodrigues Marcelo P. , Vissoci Carolina M. , Rosa Samuel P. , Negreiros Sandra B.C. 
Published: May 2017

Background:The quantification of hypoxia based on resting partial pressure of arterial oxygen (PaO2) may underestimate hypoxia related to activities of daily living or sleep and thus not accurately reflect pulmonary hypertension (PH). The aim of the present study was to investigate the association of resting PaO2with percent time of SpO2below 90% (T90) and 88% (T88) in 24 hours. We also evaluated the capacity of hypoxia measures to predict PH in patients with idiopathic pulmonary fibrosis (IPF).Method:This cross-sectional study included 27 patients with IPF presenting PaO2≥ 55 mmHg and not receiving home oxygen therapy. All were submitted to blood gas measurement, 24-h oximetry, and transthoracic Doppler echocardiography to estimate systolic pulmonary artery pressure (SPAP). Patients were divided into three groups according to resting PaO2: 55-55.9 mmHg (A); 60-60.9 mmHg (B); ≥ 70 mmHg (C). PH was defined as “likely” if SPAP > 50 mmHg, and as possible for SPAP between 37 and 50 mmHg.Results:T90 and T88 in Groups A, B, and C were as follows: 59.9±29% and 44.1±34%; 49.3±34% and 29.9±31%; 17.1±25% and 8.8±18% respectively, with significant differences between the groups for both T90 (p ≤ 0.01) and T88 (p = 0.02). PaO2was inversely correlated with T90 (r = -0.398;p = 0.04) and T88 (r = -0.351;p = 0.07). Hypoxia variables did not correlate with SPAP, and were not able to predict PH.Conclusion:Percent time of SpO2below 90% and 88% in 24 hours revealed periods of severe hypoxia even in patients with borderline-normal resting PaO2. However, none of the present hypoxia variables was capable of predicting PH.
Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma
Authors: Kase Satoru , Chin Shiki , Hamanaka Teruhiko , Shinmei Yasuhiro , Ohguchi Takeshi , Kijima Riki , Matsuda Akira , Ishida Susumu 
Published: May 2017

Purpose:
The aim of this study was to report a case of atopic dermatitis showing elevated intraocular pressure (IOP) beyond the baseline levels followed by a modified 360-degree suture trabeculotomy, and to analyze the histological findings in the trabecular meshwork.

Methods:
A 40-year-old male suffered from blurred vision in the right eye (OD). He had a medical history of severe atopic dermatitis and intraocular lens implantation OU due to atopic cataract. At the initial presentation, the visual acuity was 0.03, and IOP was 35 mmHg OD. Slit-lamp examination demonstrated corneal epithelial edema OD. Increased IOP was refractory to several topical medications. The patient underwent a modified 360-degree suture trabeculotomy. The visual field defect, however, deteriorated with persistently high IOP. The patient underwent trabeculectomy together with drainage implant surgery. In the outflow routes, although there seemed to be an opening of Schlemm’s canal into the anterior chamber, there was no endothelium of the canal in the region of its opening. The fibrotic changes were conspicuous around Schlemm’s canal.

Conclusion:
The histological results indicated that trabeculotomy might not be an appropriate treatment for patients with atopic glaucoma, possibly because of excessive repair to the newly created uveoscleral outflow in addition to the increased postoperative fibrosis in the trabecular meshwork and Schlemm’s canal.
Who is More Likely to Use the Internet for Health Behavior Change? A Cross-Sectional Survey of Internet Use Among Smokers and Nonsmokers Who Are Orthopedic Trauma Patients
Authors: McCrabb Sam , Baker Amanda L , Attia John , Balogh Zsolt J , Lott Natalie , Palazzi Kerrin , Naylor Justine , Harris Ian A , Doran Christopher , George Johnson , Wolfenden Luke , Skelton Eliza , Bonevski Billie 
Published: May 2017

Background
eHealth presents opportunities to provide population groups with accessible health interventions, although knowledge about Internet access, peoples’ interest in using the Internet for health, and users’ characteristics are required prior to eHealth program development.

Objective
This study surveyed hospital patients to examine rates of Internet use, interest in using the Internet for health, and respondent characteristics related to Internet use and interest in using the Internet for health. For patients who smoke, preferences for types of smoking cessation programs for use at home and while in hospital were also examined.

Methods
An online cross-sectional survey was used to survey 819 orthopedic trauma patients (response rate: 72.61%, 819/1128) from two public hospitals in New South Wales, Australia. Logistic regressions were used to examine associations between variables.

Results
A total of 72.7% (574/790) of respondents had at least weekly Internet access and more than half (56.6%, 357/631) reported interest in using the Internet for health. Odds of at least weekly Internet usage were higher if the individual was born overseas (OR 2.21, 95% CI 1.27-3.82, P=.005), had a tertiary education (OR 3.75, 95% CI 2.41-5.84, P<.001), or was a nonsmoker (OR 3.75, 95% CI 2.41-5.84, P<.001). Interest in using the Internet for health increased with high school (OR 1.85, 95% CI 1.09-3.15, P=.02) or tertiary education (OR 2.48, 95% CI 1.66-3.70, P<.001), and if household incomes were more than AUS $100,000 (OR 2.5, 95% CI 1.25-4.97, P=.009). Older individuals were less interested in using the Internet for health (OR 0.98, 95% CI 0.97-0.99, P<.001).

Conclusions
Online interventions may be a potential tool for health care in this hospitalized population.

Trial Registration
Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12614001147673; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=366829&isReview=true (Archived by WebCite at http://www.webcitation.org/6qg26u3En)
Karakteristik Respon Siswa Dalam Menyelesaikan Soal Geometri Berdasarkan Taksonomi SOLO
Authors: Hasan Buaddin 
Published: May 2017

Abstrak Taksonomi Solo menyediakan suatu pendekatan untuk mengevaluasi dan mengkategorikan kinerja kognitif dengan mempertimbangkan struktur hasil belajar yang diamati. Penelitian ini mengkaji respon siswa dalam menyelesaikan tugas berdasarkan taksonomi Solo. Peneliti mengukur kualitas jawaban berdasarkan pada kompleksitas pemahaman siswa terhadap soal yang diberikan. Penelitian ini menggunakan metode kualitatif eksploratif. Sumber data penelitian ini adalah siswa kelas X TKJ SMK Ibnu Cholil Bangkalan. Hasil penelitian menunjukkan bahwa respon siswa dalam menyelesaikan soal berada pada level multistruktural, relasional dan extended abstrak. Siswa kategori rendah mencapai level multistruktural karena mereka mampu membuat beberapa koneksi dan fokus pada beberapa aspek. Siswa kategori sedang memberikan respon maksimal pada level relasional karena mengaitkan konsep atau proses sehingga semua informasi terhubung secara relevan dan diperoleh kesimpulan yang relevan. Siswa kategori tinggi mencapai level extended abstrak karena mampu mengaitkan konsep atau proses sehingga semua informasi terhubung secara relevan dan diperoleh kesimpulan yang relevan serta menggunakan prinsip umum yang tidak terdapat dalam soal.
Optimizacija geometrijskih veličina toplotnih prijemnika sunčeve energije heurističkim optimizacionim metodama
Authors: Kostić Nenad , Matejić Miloš , Blagojević Mirko , Marjanović Nenad 
Published: May 2017

Ovaj rad predstavlja nastavak istraživanja grupe autora u oblasti optimizacije efikasnosti toplotnih prijemnika sunčeve energije (u daljem tekstu: PSE). Dosadašnji rad se zasnivao na metodi optimizacije poznatoj kao metoda slučajne pretrage, kao jedne od najstarijih heurističkih optimizacionih metoda. U radu su rezultati prethodnih istraživanja upoređeni sa rezultatima dobijenim novom metodom optimizacije koja se naziva teaching-learning based optimization – TLBO. Predstavljen je način funkcionisanja ove metode, kao njena primena na optimizaciju toplotnih PSE-a. Za potrebe ovog rada unapređen je dosadašnji matematički model, kako bi u optimizaciju bio uključen što veći broj promenljivih koje imaju uticaja kako na proizvodnju tako i na cenu PSE-a. U obzir su uzeti prijemnici sa cevima kvadratnog poprečnog preseka, kao i prijemnici sa cevim okruglog poprečnog preseka. Izvedeni su zaključci i data je uporedna analiza rezultata dobijenih metodom slučajne pretrage i metodom TLBO.
Promjena termičke ugodnosti u fazi pothlađivanja putničkog prostora
Authors: Grahovac Svetozar 
Published: May 2017

Jedan od zadataka proizvođača današnjih vozila predstavlja razvoj novih i optimizacija postojećih sistema za postizanje i održavanje termičke ugodnosti u putničkom prostoru. Bez ispravnog izbora i dimenzionisanja sistema grijanja, hlađenja i provjetravanja putničkog prostora, nema ni termičke ugodnosti. Za računarsku obradu termičke ugodnosti na dva izabrana sjedišta, koriste se 4 mjerena parametra: brzina kretanja vazduha, vlažnost vazduha, temperatura vazduha i temperatura crne kugle. Pored predskazivanja procenta nezadovoljnih u fazi pothlađivanja unutrašnjosti vozila, ukazuje se i na specifičnost termičkih uslova u vozilima. U radu se vrši poređenje termičke ugodnosti za nehomogenu i homogenu sredinu. Korištenjem operativne i ekvivalentne temperature prema SAE J2234, dolazi se do homogene sredine. Na sjedištima se pretpostavlja ista aktivnost osoba i ista vrsta odjeće. Uslovi vanjske okoline: brzina nastrujavanja vozila, temperatura vazduha i vlažnost vazduha su konstantni. Cilj rada je ukazati i na složenost ispitivanja termičke ugodnosti u putničkim vozilima.
Problemi kondenzacije vlage na staklenim površinama bazenskih objekata i LCC analiza raznih kompozicija klima-komora
Authors: Pjević Aleksandar 
Published: May 2017

U radu su predstavljeni problemi kondenzacije vlage iz vazduha na staklenim površinama bazenskih objekata u područjima sa niskom temperaturom spoljašnjeg vazduha i preporuke za projektovanje. Takođe je prikazana uporedna analiza LCC troškova životnog veka različitih koncepcija klimatizacionih agregata za obradu vazduha i izloženi zaključci.
A pós-graduação em Educação e a especificidade da pesquisa educacional
Authors: Saviani Dermeval 
Published: May 2017

Este artigo busca mostrar que, sendo o objetivo da pós-graduação “stricto sensu” a formação do pesquisador, o mestrado em educação desempenha papel fundamental na formação de pesquisadores educacionais. Para tanto, no primeiro momento se esclarece o conceito de pós-graduação caracterizando, no segundo momento, o processo de implantação da pós-graduação no Brasil para, no terceiro momento, explicitar o significado de pesquisa educacional evidenciando sua especificidade. Constata-se, enfim, que, se toda pós-graduação em educação envolve, de algum modo, pesquisa relacionada à educação, nem toda pós-graduação em educação desenvolve pesquisas especificamente educacionais. Conclui-se, então, pela necessidade de que os Programas de Mestrado em Educação se capacitem para produzir pesquisas educacionais em sentido próprio.
La descentralización territorial autonomía territorial y regionalización política
Authors: Brewer Carías Allan Randolph 
Published: May 2017

SUMARIO: I. INTRODUCCIÓN. — II. LA DESCENTRALIZACIÓN POLÍTICA COMO FENÓMENO Y EXIGENCIA CONTEMPORÁNEOS: 1. LA CRISIS DEL ESTADO NACIONAL CENTRALIZADO. 2. LA CRISIS DE LAS CLÁSICAS FORMAS DE ESTADO Y LA SUPERACIÓN DE LA DICOTOMÍA: ESTADO UNITARIO/ESTADO FEDERAL. 3. EL CENTRALISMO DE LAS VIEJAS FEDERACIONES. 4. LOS NUEVOS FEDERALISMOS. 5. LA DESCENTRALIZACIÓN DE LOS ESTADOS UNITARIOS. — III. LA FORMULA DEL ESTADO REGIONAL: 1. ANTECEDENTES. 2. EL ESTADO REGIONAL ITALIANO. 3. E L ESTADO DE COMUNIDADES Y REGIONES DE BÉLGICA. 4. E L ESTADO DE COMUNIDADES AUTÓNOMAS ESPAÑOL. 5. LA REGIONALIZACIÓN POLÍTICA DE FRANCIA Y EL ESTADO REGIONAL. 6. OTRAS EXPERIENCIAS DE REGIONALIZACIÓN POLÍTICA. — IV. CONCLUSIÓN.
PROMOÇÃO DO ALEITAMENTO MATERNO NA PRIMEIRA HORA DE VIDA DO RECÉM-NASCIDO POR PROFISSIONAIS DA ENFERMAGEM
Authors: Leite Maura Fernanda Ferreira da Silva , Barbosa Priscila Araújo , De Olivindo Dean Douglas Ferreira , Ximenes Valessa de Lima 
Published: May 2017

O aleitamento materno é a principal maneira de proporcionar a alimentação ideal para o crescimento e desenvolvimento de forma saudável para o neonato. O estudo tem como objetivo descrever e analisar a percepção das puérperas acerca do incentivo ao aleitamento materno na primeira hora de vida pelos profissionais de enfermagem em uma maternidade pública. Trata-se de uma pesquisa qualitativa descritiva. As participantes da pesquisa foram 24 puérperas que pariram na maternidade e que aceitaram participar da pesquisa. O instrumento para coleta de dados foi a entrevista semiestruturada. Todas as pesquisadas assinaram um Termo de Consentimento Livre e Esclarecido. Os depoimentos revelaram que todas as puérperas possuíam um conhecimento prévio quanto aos benefícios e importância da amamentação e que a maioria das entrevistadas receberam uma assistência humanizada voltada ao incentivo da amamentação. Conclui-se que é de suma importância ressaltar que seja oferecido um apoio profissional na afirmação do contato pele a pele precoce entre mãe e filho, para a elevação de ações de cuidado e que não haja limitações por parte do profissional enfermeiro no espaço que envolva esta interação, visando um bom entendimento entre eles.
ESTUDO COMPARATIVO DA ATIVIDADE ANTIBACTERIANA DE EXTRATOS VEGETAIS DE Senna spectabilis, Rosmarinus officinalis E Eugenia uniflora FRENTE À CEPA PADRÃO DE Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 6538 E Streptococcus pyogenes ATCC 19615
Authors: Arantes Vinicius Pereira , Dos Santos Lays Fernandes , Diniz Karen da Silva , Silva Gabriela Oliveira da , Costa Gustavo Meireles 
Published: May 2017

O interesse em terapias alternativas e o uso terapêutico por derivados de plantas vêm crescendo nos últimos anos, obtendo um grande avanço científico no aspecto químico e farmacológico, a Organização Mundial da Saúde (OMS), considera as plantas medicinais como importantes instrumentos da assistência farmacêutica. Objetivo: Determinar atividade antibacteriana comparada entre os extratos de Senna spectabilis, Rosmarinus officinalis e Eugenia uniflora frente à cepa padrão de Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 6538 e Streptococcus pyogenes ATCC 19615. As folhas de E. uniflora, R. officinallis e S. spectabilis foram coletadas no Horto de plantas medicinais da Universidade Estadual de Maringá – UEM/PR e as cepas foram fornecidas pela Universidade Paranaense – Unipar. A atividade antibacteriana foi determinada por meio da técnica do microdiluição em placa, empregando revelador de crescimento Alamar Blue Assay (MABA). A concentração mínima inibitória (CIM) empregando R. officinalis, E. uniflora, frente a cepa de S. aureus ATCC pode revelar resultados de 125 µg/mL, para extratos de S. spectabilis o CIM foi de 250 µg/mL; para S. pyogenes o CIM de 125 µg/mL foi admitido apenas para R. officinalis e S. spectabilis, E. uniflora apresentou resultados de 500 µg/mL, para P. aeruginosa o CIM para os três extratos foi superior a 500 µg/mL. Os extratos são promissores quando empregados contra S. aureus e S. pyogenes, exceto para P. aeruginosa, no entanto cabe buscar novas alternativas para tratamento deste Gram-negativo.
La recepción española de la obra de Samuel Johnson en las traducciones al castellano
Authors: Pascual Garrido María Luisa 
Published: May 2017

Abstract: The present study analyses the reception of Samuel Johnson in Spain through the translation of his works into Spanish. Despite the immense influence Samuel Johnson has had in the English-speaking world as one of the most significant representatives of enlightened Humanism, the knowledge of his works and his figure have been rather belated in the Hispanic world. His marked “Englishness” may be considered one of the causes why his works went unnoticed among his Spanish contemporaries and the following generations at a time when political and cultural alliances linked Spain to France rather than to Great Britain. A determining factor in the process of making Samuel Johnson better-known in Spain has been the development of English Studies as an academic discipline, especially since the 1980’s. The second important factor is the availability of Spanish translations of the famous biography signed by James Boswell.Resumen: El presente estudio analiza la recepción de la obra de Samuel Johnson en España a través de las traducciones al castellano. Pese a la inmensa influencia de la que goza Samuel Johnson en el mundo angloparlante como máximo representante del humanismo ilustrado, la difusión tanto del autor como de su obra ha sido tardía en el ámbito hispánico. Su marcado carácter “inglés” puede considerarse como una de las causas del aparente desinterés que su obra despertó entre sus coetáneos y las generaciones inmediatamenteposteriores en una época en las que las alianzas políticas y culturales ligabanEspaña a Francia. Un factor determinante en la divulgación de la obra de Johnson ha sido el desarrollo como disciplina académica de los Estudios de Filología inglesa, en especial a partir de la década de 1980. El segundo factor es la aparición de varias traducciones españolas de la famosa biografía sobre la vida de Johnson firmada por James Boswell.
Sula, a Dark Lady
Authors: López Ramírez Manuela 
Published: May 2017

Abstract: Through Sula (the main character of Toni Morrison’s eponymous novel), Morrison reinterprets the concept of the Dark Lady of the traditional Gothic romance. She is a demonic female, who defi es the Law of the Father in her search for identity. As the embodiment of subversion, she becomes the “village witch”, the symbolic expression of the African community’s confrontation with evil. In fact, through Sula, Morrison refl ects intensively on evil. The demonic female comes to be a scapegoat, the target of the black community’s social frustrations. Sula is a modern Dark Lady with a radical power of self-creation and self-affi rmation. Resumen: A través de Sula (el personaje principal de la novela homónima de Toni Morrison), la autora reinterpreta el concepto de la Mujer Oscura del romance gótico tradicional. Ella es una mujer demoníaca, que desafía la Ley del Padre en su búsqueda de identidad; convirtiéndose en la “bruja del pueblo”, símbolo de la confrontación de la comunidad africana con el mal. A través de Sula, Morrison refl exiona extensamente sobre el mal. La mujer demoníaca se convierte en el objetivo de las frustraciones sociales de la comunidad negra. Sula es una Mujer Oscura moderna con un poder radical de auto-creación y auto-defi nición