bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic impact of integrated 18F-FDG PET/MRI in cerebral staging of patients with non-small cell lung cancer
Authors: Deuschl Cornelius , Nensa Felix , Grueneisen Johannes , Poeppel Thorsten D , Sawicki Lino M , Heusch Philipp , Gramsch Carolin , Mönninghoff Christoph , Quick Harald H , Forsting Michael , Umutlu Lale , Schlamann Marc 
Published: March 2017

Background Integrated positron emission tomography/magnetic resonance imaging (PET/MRI) systems are increasingly being available and used for staging examinations. Brain metastases (BM) are frequent in patients with non-small cell lung cancer (NSCLC) and decisive for treatment strategy. Purpose To assess the diagnostic value of integrated 18F-2-fluoro-2-deoxy-D glucose (18F-FDG) PET/MRI in initial staging in patients with NSCLC for BM in comparison to MRI alone. Material and Methods Eighty-three patients were prospectively enrolled for an integrated 18F-FDG PET/MRI examination. The 3 T MRI protocol included a fluid-attenuated inversion-recovery sequence (FLAIR) and a contrast-enhanced three-dimensional magnetization prepared rapid acquisition GRE sequence (MPRAGE). Two neuroradiologists evaluated the datasets in consensus regarding: (i) present lesions; (ii) size of lesions; and (iii) number of lesions detected in MRI alone, compared to the PET component when reading the 18F-FDG PET/MRI. Results Based on MRI alone, BM were detected in 15 out of the 83 patients, comprising a total of 39 metastases. Based on PET alone, six patients out of the 83 patients were rated positive for metastatic disease, revealing a total of 15 metastases. PET detected no additional BM. The size of the BM correlated positively with sensitivity of detection in PET. Conclusion The sensitivity of PET in detection of BM depends on their size. 18F-FDG PET/MRI does not lead to an improvement in diagnostic accuracy in cerebral staging of NSCLC patients, as MRI alone remains the gold standard.
Measurements of myocardial bridges on computed tomography predict presence of clinical symptoms and outcomes of adverse heart events: a retrospective study in a large population from China
Authors: Liu Guobing , Qu Yanjuan , Chen Xin , Liao Meiyan , Hu Huijuan , Cao Yiyuan , Tian Zhixiong 
Published: March 2017

Background Clinical-radiological correlation of myocardial bridge (MB) remains unclear. Purpose To correlate clinical symptoms and outcomes of MBs with computed tomography (CT) coronary angiography findings. Material and Methods A total of 2092 patients with CT coronary angiography were collected. Patients were divided into symptomatic and asymptomatic groups, adverse heart events (AHE) and non-AHE groups, MB and non-MB groups, as well as left anterior descending (LAD)-MB and non-LAD-MB groups. Statistical analyses were performed to identify inter-group differences, and clinical-radiological correlations of MBs or mural coronary arteries (MCAs). Results The prevalence of MB, the MCA stenosis either in systole or in diastole, and the ratio of LAD-MB were significantly higher in the symptomatic group than in the asymptomatic group, and higher in the AHE group than in the non-AHE group ( P all <0.05). MB thickness, systolic MCA stenosis, and diastolic MCA stenosis were independent variables predicting clinical symptoms ( P < 0.05), with diastolic MCA stenosis having the highest diagnostic performance, when cutting at 24.6%. The corresponding sensitivity and specificity were 87.8% and 90.6%, respectively. Diastolic MCA stenosis independently indicated outcome of AHE (odds ratio, 1.047; P < 0.001). Conclusion Measurements of MB-MCA by CT predict the presence of clinical symptoms and outcomes of AHE, with diastolic MCA stenosis possessing the greatest performance.
A multi-reader in vitro study using porcine kidneys to determine the impact of integrated circuit detectors and iterative reconstruction on the detection accuracy, size measurement, and radiation dose for small (<4 mm) renal stones
Authors: Wells Michael L , Froemming Adam T , Kawashima Akira , Vrtiska Terri J , Kim Bohyun , Hartman Robert P , Holmes David R , Carter Rickey E , Bartley Adam C , Leng Shuai , McCollough Cynthia H , Fletcher Joel G 
Published: March 2017

Background Detection of small renal calculi has benefitted from recent advances in computed tomography (CT) scanner design. Information regarding observer performance when using state-of-the-art CT scanners for this application is needed. Purpose To assess observer performance and the impact of radiation dose for detection and size measurement of <4 mm renal stones using CT with integrated circuit detectors and iterative reconstruction. Material and Methods Twenty-nine <4 mm calcium oxalate stones were randomly placed in 20 porcine kidneys in an anthropomorphic phantom. Four radiologists used a workstation to record each calculus detection and size. JAFROC Figure of Merit (FOM), sensitivity, false positive detections, and calculus size were calculated. Results Mean calculus size was 2.2 ± 0.7 mm. The CTDIvol values corresponding to the automatic exposure control settings of 160, 80, 40, 25, and 10 Quality Reference mAs (QRM) were 15.2, 7.9, 4.2, 2.7, and 1.3 mGy, respectively. JAFROC FOM was ≥ 0.97 at ≥ 80 QRM, ≥ 0.89 at ≥ 25 QRM, and was inferior to routine dose (160 QRM) at 10 QRM (0.72, P < 0.05). Per-calculus sensitivity remained ≥ 85% for every reader at ≥ 25 QRM. Mean total false positive detections per reader were ≤ 3 at ≥ 80 QRM, but increased substantially for two readers ( ≥ 12) at ≤ 40 QRM. Measured calculus size significantly decreased at ≤ 25 QRM ( P ≤ 0.01). Conclusion Using low dose renal CT with iterative reconstruction and ≥ 25 QRM results in high sensitivity, but false positive detections increase for some readers at very low dose levels (≤ 40 QRM). At very low doses with iterative reconstruction, measured calculus size will artifactually decrease.
Indocyanine green detects sentinel lymph nodes in early breast cancer
Authors: Liu Jun , Huang Linping , Wang Ning , Chen Ping 
Published: March 2017

Objective To explore the clinical value of indocyanine green (ICG) for the fluorescence-guided detection of sentinel lymph nodes (SLNs) during sentinel lymph node biopsy (SLNB) in patients with early breast cancer. Methods This retrospective study included female patients with breast cancer. Patients were administered methylene blue and ICG using standard techniques. All SLNs that were collected during surgery were submitted for pathological examination. SLNs were defined as those that were either fluorescent, blue, fluorescent and blue or palpably suspicious. Surgical complications, axillary recurrence, distant metastasis and overall survival rates were observed postoperatively. Results A total of 60 patients were enrolled in the study. The fluorescence detection rate of SLNs was 100% ( n = 177), with a mean of 2.95 SLNs per patient. The methylene blue staining rate was 88.3% ( n = 106), with a mean of 1.77 SLNs per patient. Pathological assessment of intraoperative frozen specimens revealed SLN metastases in 10 patients, who immediately underwent axillary lymph node dissection. No patient had axillary recurrence or distant metastases, with a survival rate of 100%. Patients who underwent SLNB showed good appearance in the axillary wound, with no limited shoulder joint abduction and upper limb oedema. Conclusion Fluorescence-guided SLNB has several advantages and is suitable for clinical application.
Effects of Lactobacillus rhamnosus and Lactobacillus acidophilus on bacterial vaginal pathogens
Authors: Bertuccini Lucia , Russo Rosario , Iosi Francesca , Superti Fabiana 
Published: March 2017

The human vagina is colonized by a variety of microbes. Lactobacilli are the most common, mainly in healthy women; however, the microbiota composition can change rapidly, leading to infection or to a state in which potential pathogenic microorganisms co-exist with other commensals. In premenopausal women, urogenital infections, such as bacterial vaginosis and aerobic vaginitis, remain an important health problem. Treatment of these infections involves different kind of antibiotics; however, the recurrence rate remains high, and it must be also underlined that antibiotics are unable to spontaneously restore normal flora characterized by an abundant community of Lactobacilli. The main limitation is the inability to offer a long-term defensive barrier, thus facilitating relapses and recurrences. We report here the antimicrobial activities of two commercially existing Lactobacillus strains, Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus GLA-14 strains and their combination (Respecta® probiotic blend) against four different pathogens responsible for both bacterial vaginosis ( Gardenerella vaginalis and Atopobium vaginae) and aerobic vaginitis ( Staphylococcus aureus and Escherichia coli) by co-culturing assay. The probiotic combination, even if resulting in a different microbicidal activity against the different strains tested, demonstrated the efficacy of combined Lactobacillus strain treatment.
Lung Adenocarcinoma Presenting as Worsening of Chronic Neck Pain—A Cautionary Tale
Authors: Akhavan Neeka N , Brar Tony S , Maska Edlira 
Published: March 2017

Introduction: Neck pain is a common musculoskeletal problem that up to 70% of the world population will experience at some point in their lives. Intramedullary spinal cord metastasis is an exceedingly rare complication of malignancy that affects less than 1% of all patients with cancer. Case report: We report a case of a 61-year-old man who presented to primary care clinic with 1-month history of worsening neck pain with associated neurologic deficits. Despite initial conservative management, the patient continued to have progressive worsening of sensory and motor deficits. Magnetic resonance imaging of the cervical spine showed vasogenic edema of the brain and spinal cord and nodularity at the C4-C5 level. A computed tomography of the chest showed a dense lesion in the left lower lobe of the lung; histopathology of the biopsied specimen was consistent with moderately differentiated lung adenocarcinoma. Conclusions: A high index of suspicion is necessary when chronic neck pain acutely worsens, changes in character, or is accompanied by neurologic deficits. These clinical signs warrant further investigation into a secondary cause of neck pain. Intramedullary spinal cord metastases are rare complications of systemic cancer that commonly present with neck pain and upper extremity paraesthesias; early diagnosis and management are necessary to prevent complications such as spinal cord hemisection syndrome or spinal cord transection.
Sun-Smart Practices Amongst School Students (Grades 5, 7, and 9) in Alberta, Canada
Authors: Jha Divya , Jha Shankar , Ghosh Sunita , Smylie Michael , Taher Muba 
Published: March 2017

Objectives: The aim of this study was to assess the current knowledge children possess on melanoma and sun-protective behaviour. Methods: A one-page survey was administered to students in grades 5, 7, and 9. Results: Three hundred ninety-two students from 11 schools in Edmonton were surveyed. Seventy-one percent of students knew that sun exposure can cause skin cancers. Sixty-nine percent were taught by their parents about sun protection, but only 44% of students received similar instructions from teachers. Twenty percent of students indicated that they never or rarely wore sunscreen. Twenty-five percent of students had experienced painful sunburns, and only 46% were willing to use sunscreen if it were available at school. More Caucasian students reported painful or peeling sunburns in each grade level than their non-Caucasian peers (for grade 5, P = .003; for grade 7, P < .0001; for grade 9, P = .001). For all grade levels, the percentage of Caucasian students who indicated that they would not wear sunscreen when going out in the sun was greater than among their non-Caucasian peers (for grade 5, P < .001; for grade 7, P = .003; for grade 9, P = .015). Conclusions: A comprehensive and focused approach to sun-smart education is recommended for students.
Confirmed and Suspected Foreign Body Injuries in Children during 2008–2013: A Hospital-Based Single Center Study in Oulu University Hospital
Authors: Sinikumpu J.- J. , Serlo W. 
Published: March 2017

Introduction: Foreign body injuries are common in children. Most of them are not serious but they can be fatal. A suspected foreign body injury in a child results in a high rate of hospitalizations, exposure to radiation, and need for intervention. This study aimed to analyze the current epidemiology of in-hospital or out of hospital treated foreign object injuries and suspected foreign body injuries in children. Material and Methods: All children <16 years of age (N = 152) who suffered or were suspected to suffer (N = 63) from a foreign body injury and were treated in a pediatric trauma unit of Oulu University Hospital, Oulu, Finland, over a 6-year study period (2008–2013) were included. A comprehensive chart review was completed in order to evaluate injury history, age at the time of trauma, treatment and characteristics of the foreign objects. Results: The majority (57.9%, N = 88) of the injuries were found in children <3 years of age. There was a male predominance (60.5%, N = 92). The most common anatomical site where the foreign body was found was the nose (28.9%, N = 44), followed by the esophagus (20.4%, N = 31) and the eye (11.2%, N = 17). Foreign objects were also found in the lower airways (10.5%, N = 16), ear (10.5%, N = 16), bowel (9.9%, N = 15), throat (3.9%, N = 6), stomach (3.9%, N = 6), and urethra (0.7%, N = 1). Various household items were the most common foreign bodies (33.6%, N = 51). Toys in particular caused 22.4% (N = 34) of the injuries. In-hospital intervention was necessary for 38.5% of the patients (N = 58). Intervention was needed in 39.7% (N = 25/63) of the patients who were suspected to suffer from foreign body but did not. There were no fatalities. Conclusion: Foreign body injuries treated at the pediatric trauma unit were most common in the youngest children (<3 years of age). Majority (61.8%, N = 94) of the patients were treated non-operatively, without any in-hospital intervention.
Outcome after cardiopulmonary resuscitation in patients with congenital heart disease
Authors: Van Puyvelde Tim , Ameloot Koen , Roggen Mieke , Troost Els , Gewillig Marc , Budts Werner , Van De Bruaene Alexander 
Published: March 2017

Background: Outcome after cardiopulmonary resuscitation (CPR) in patients with underlying congenital heart disease is uncertain. This study aimed at evaluating outcome after CPR in patients with underlying congenital heart disease, factors related to worse outcome after CPR and whether survivors of sudden cardiac death (SCD) have a worse outcome when compared to an age, gender and disease-matched control population. Methods: Between 1984 and 2015, all patients with congenital heart disease who received in or out-of-hospital CPR were identified from the database of congenital heart disease from the University Hospitals Leuven. Postoperative and neonatal (<6 months of age) CPR was excluded. For each survivor of SCD, two control patients matched for gender, age and underlying heart defect were included in the study. Results: Thirty-eight patients (66% men; median age 25 years (interquartile range 9–40); 68% out-of-hospital) were identified, of which 27 (66%) survived the event. The main cause of SCD was ventricular tachycardia or fibrillation ( n=21). Heart defect complexity (odds ratio (OR) 5.1; 95% confidence interval (CI) 1.2–21.9; P=0.027), pulmonary hypertension (OR 13.8; 95% CI 2.1–89.5; P=0.006) and time to return of spontaneous circulation (OR 1.1; 95% CI 1.0–1.1; P=0.046) were related to worse outcome. Survivors of SCD had a worse prognosis when compared to an age, gender and disease-matched control group (5-year survival 76% vs. 98%; P=0.002). Conclusions: The complexity of underlying heart defect, pulmonary hypertension and time to return of spontaneous circulation are related to worse outcome in the case of CPR. Survivors of SCD have a worse outcome when compared to matched controls, indicating the need for adequate implantable cardioverter defibrillator indication assessment and for stringent follow-up of patients with worsening haemodynamics.
Preference and willingness to pay for nutritional counseling services in urban Hanoi
Authors: Nguyen Hai Viet , Trinh Ngoc Bao , Le Huong Thi , Nguyen Cuong Tat , Mai Hue Thi , Tran Tho Dinh , Le Huong Thi , Tran Bach Xuan , Vu Thuc Thi Minh 
Published: March 2017

Background:Despite substantial achievement in reducing malnutrition rates in Vietnam, there has been an increasing rate of overweight individuals in urban areas, which may result in a high burden of non-communicable diseases. Nutritional counseling clinics have been introduced in several settings; however, little is known about the preference for this service among urban clients. This study aimed to assess the preference and willingness to pay (WTP) for nutritional counseling services among urban clients. Methods:We interviewed 429 clients who attended Hanoi Medical University Nutritional Counseling Clinic (Hanoi, Vietnam). WTP was determined using double-bounded dichotomous-choice questions and open-ended questions. Results:In total, 78.6% respondents were willing to use nutritional counseling services. The mean amount of WTP for one-time service and one-year package was 96,100VND (~$4.3) and 946,400VND (~$41.9), respectively. Clients’ willingness to use the service was higher among females, those seeking counseling for elderly people and those who preferred face-to-face counseling services (p<0.05). WTP was higher among those who were over 35 years old, those seeking services for the elderly people, those having poor nutritional status, and those having under-6 year old children (p<0.05). Conclusions:The preference and WTP for nutritional counseling services in urban Hanoi were relatively high. Scaling up this service is necessary to actively prevent and control the spread of non-communicable diseases.
Bases of Scientific Data, Citation Index, and How to Increase It
Authors: Девисилов  , Devisilov Vladimir 
Published: March 2017

Scientometrical indicators for scientist activity, scientific magazines, citation indexes, methods of their definition and work with them have been considered. Main bases for scientific data – Scopus, Web of Science, Russian index of scientific citation (Russian science citation index) have been presented, rules of their use and work with them. Merits and demerits of the main scientometrical indicators are analyzed and recommendations for increase of scientist citation index are given. Scientific article’s structure, as well as requirements to its basic elements influencing a paper’s citation level, have been explained, recommendations for preparation of
such paper’s basic elements as its heading, abstract, keywords, citable sources’ bibliography have been given. The structure for the paper’s main text has been considered and recommendations on its writing have been given. A conclusion is drawn that one of the reasons related to low level citation of Russian scientists, and references to publications in Russian magazines is a lack of culture in writing of scientific papers and not observance of their preparation rules that complicates their annotation in bases of scientific data.
Eventratio diaphragmatica
Authors: Martodipuro Subagjo , Sunarjo Nurjono , Suparto Pitono , Partana L. 
Published: March 2017

A diaphragmatic eventration is a displacement of abdominal structures into the thoracic cavity, due to weakness and balooning of the diaphragm (Nelson, 1969). In several aspects it has similarities with a diaphragmatic hernia, i.e. the space occupying effects to the lungs, and the sequences of it. An eventration can be divided in 2 groups, the congenital eventration, where the diaphragm is devoid of mucles and only a membrane is separating the abdominal from the pleural cavity; and the acquired one where the phrenic nerve is damaged, usually due to birth injury; but it can also be caused by any other trauma (Bernado et aI., 1961; Bisono et aI., 1970) such as surgical procedures at the time of thoracotomy, the so called iatrogenic eventration (Jewett et aI., 1964).
Exploring the professional self-efficacy perceptions of the teachers of children in need of special education in terms of various variables<p>Özel eğitim gereksinimli çocukların öğretmenlerinin mesleki özyeterlilik algılarının çeşitli değişkenlere göre incelenmesi
Authors: Gerez Cantimer Gülşah , Şengül Sare , Akçin Nur 
Published: March 2017

The need for special education is gaining importance each passing day with increasing the number of children in need of special education. Since self-efficacy perceptions of teachers of children in need of special education which is related their field will shape the education given, the identifying current situation is seen important for resolving deficienciens. Therefore, the purpose of the study is to develop “The Special Education Teachers’ Sense of Professional Self-Efficacy Scale (SET-SPSES)” (Study I) and reveal whether the level of professional self-efficacy perceptions of the special education teachers show differences depending on a variety of variables (gender, age, educational background, professional experience, and special needs of students) (Study II). SET-SPSES was found to be a suitable instrument in accordance with Study II that was made the validity and the reliability. The research was carried out with 464 teachers graduating from a special education program and working in the academic year of 2013-2014 in Istanbul. According to the research findings; it was determined that the special education teachers had an adequate level of teaching self-efficacy perception and that their perceptions did not significantly vary by gender, age, professional experience, and special needs of students, but significantly varied by education level. ÖzetÖzel eğitim gereksinimli çocukların sayısının her geçen gün artmasıyla özel eğitime duyulan ihtiyaç önem kazanmaktadır. Özel eğitim gereksinimli çocukların öğretmenlerinin alanlarına yönelik özyeterlilik algıları verdikleri eğitimi şekillendireceğinden varolan durumun tespit edilmesi eksiklerin giderilmesi adına önemli görülmektedir. Bu nedenle çalışmada “Özel Eğitim Öğretmenlerinin Mesleki Özyeterlilik Algısı Ölçeği (ÖEÖ-MÖAÖ)” geliştirilerek (Çalışma I) özel eğitim öğretmenlerinin mesleki özyeterlilik algılarının düzeylerinin çeşitli değişkenlere (cinsiyet, yaş, öğrenim durumu, mesleki deneyim ve öğrencinin özel gereksinim durumu) göre farklılık gösterip göstermediğinin ortaya konulması (Çalışma II) amaçlanmıştır. Çalışma I’de yapılan geçerlik ve güvenirlik çalışmaları doğrultusunda Özel Eğitim Öğretmenlerinin Mesleki Özyeterlilik Algısı Ölçeği’nin kullanılabilir özelliklere sahip olduğu bulunmuştur. Araştırma 2013-2014 eğitim-öğretim yılında İstanbul ilinde görev yapmakta olan toplam 464 özel eğitim alan mezunu öğretmen ile gerçekleştirilmiştir. Araştırma bulgularına göre; özel eğitim öğretmenlerinin mesleki özyeterlilik algılarının yeterli düzeyde olduğu; cinsiyet, yaş, mesleki deneyim ve öğrencinin özel gereksinim durumu ile anlamlı bir farklılık göstermediği, öğrenim durumu ile anlamlı bir farklılık gösterdiği belirlenmiştir.