bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcome and prognosis of dogs with histopathological features consistent with epitheliotropic lymphoma: a retrospective study of 148 cases (2003–2015)
Authors: Chan Catherine M. , Frimberger Angela E. , Moore Antony S. 
Published: October 2017

BackgroundLimited information is available regarding the treatment and outcome of dogs with epitheliotropic lymphoma. The disease typically has a poor prognosis.ObjectivesTo characterize the clinical signs, identify prognostic factors and evaluate the treatment outcome of dogs with epitheliotropic lymphoma.MethodsA retrospective review of medical records from 2003 to 2015. Treatment details, tumour response and survival time were recorded for 148 dogs. Potential prognostic factors were evaluated for their statistical effect on median survival time.ResultsThe overall median survival time for dogs was 264 days (cutaneous: 130 days; mucocutaneous/mucosal: 491 days). On multivariate analysis, a shorter median survival time was associated with the cutaneous form (P< 0.001) and the presence of multiple lesions (P< 0.001). Among 80 dogs with cutaneous lesions, chemotherapy treatment (P< 0.001) and having a solitary lesion (P< 0.001) were associated with longer median survival. In 72 dogs with multiple cutaneous lesions, chemotherapy intervention (P< 0.001), retinoid treatment (P= 0.001) and complete remission (P= 0.001) were associated with longer median survival. In 68 dogs with mucocutaneous/mucosal lesions, decreasing age (P= 0.020) and a solitary lesion (P= 0.015) were associated with longer median survival.ConclusionCanine epitheliotropic lymphoma may be divided into cutaneous and mucocutaneous/mucosal forms. Solitary lesions have a better prognosis. Dogs with multiple lesions appear to benefit from chemotherapy and retinoid treatment, with those attaining complete remission having longer survival times. Multi‐agent chemotherapy could be considered in dogs with cutaneous lesions that fail to respond to single‐agent chemotherapy.
Temporal trends in Giardia occurrence in the Grand River and surrounding tributaries, Waterloo, Ontario (2005–2013), a retrospective analysis of surveillance data
Authors: Swirski A. L. , Pearl D. L. , Peregrine A. S. , Thomas J. , Pintar K. 
Published: October 2017

SummaryGiardia contamination in the Grand River Watershed (south‐western Ontario, Canada) was monitored from 2005 to 2013 as part of FoodNet Canada. Our study objectives were to describe the temporal pattern of Giardia occurrence and determine whether water quality parameters and bacterial indicators could act as effective markers for Giardia occurrence. Water samples were collected monthly from the Grand River near a drinking water intake point (2005–2013) and also collected intermittently from other areas in the watershed during the study period. Samples were tested for Giardia cysts using the US EPA method 1623. Samples were also tested for chemical and microbial water quality indicators. Univariable and multivariable linear regression models were built to examine whether temporal, water quality and bacterial indicators were associated with Giardia cyst concentration. Giardia cysts were identified in 89% of samples (n = 228), with highest measured concentrations downstream of a waste water treatment plant outfall. Year and season were found to be predictors for Giardia occurrence. Concentrations were significantly higher in the winter and fall compared to the summer, and significantly higher in 2007 compared to other study years. After controlling for season, year and sampling location, dissolved oxygen was the only variable significantly associated with Giardia cyst concentration. Seasonal peaks in Giardia cyst concentrations in samples collected near the intake for the drinking water plant did not align with the seasonal peak in human Giardiasis cases in this region that are reported annually by public health authorities. This suggests that the risk of contracting Giardiasis from treated drinking water in this community is possibly low when the treatment plant is functioning adequately. Instead, waterborne exposure is likely the result of seasonal behaviours surrounding recreational water use. Therefore, the collective findings of our study are important to help inform future risk management studies and guide public health protection policies.
A cross‐sectional study of intestinal parasitoses in dogs and children of the periurban area of La Plata (Buenos Aires, Argentina): Zoonotic importance and implications in public health
Authors: Cociancic P. , Zonta M. L. , Navone G. T. 
Published: October 2017

SummaryA cross‐sectional study was performed between school term dates 2014 and 2015 to diagnose intestinal parasites in dogs and children living with them. The socio‐environmental characteristics and hygiene practices of the children were also evaluated in terms of risk factors for parasitic infection of periurban neighbourhoods of La Plata (Buenos Aires, Argentina). Serial coproparasitological samples of 78 dogs and 211 children were analysed by means of concentration and flotation techniques. Socio‐environmental variables and hygiene practices of children were evaluated through semi‐structured questionnaires which were answered by every family. The study showed that 82.1% of dogs were parasitized. The specific richness was of 11 species; Ancylostoma caninum (69.2%), Uncinaria stenocephala (41.0%), Trichuris vulpis (28.2%) and Toxocara canis (21.8%) were the most prevalent. The study also revealed that 67.8% of children were positive. Also, 11 species were identified and the most prevalent were Blastocystis sp. (36.0%), Enterobius vermicularis (27.5%) and Giardia lamblia (21.3%). The risk for parasitosis was higher in 6‐year‐old children and older (OR = 1.9, 95% IC: 1.0–3.7) and in those who did not wash their hands or did it occasionally after playing with their pets (OR = 2.8, 95% IC: 1.4–5.5). Blastocystis sp. and Entamoeba coli infection risks were greater in children whose parents had a basic level of education (OR = 3.4, 95% IC: 1.3–8.7 and OR = 3.6, 95% IC: 0.8–15.9, respectively). In addition, the risk of infection for E. coli was higher in children who lived in floodable houses (OR = 4.4, 95% IC: 0.9–16.6). Likewise, the risk of infection for E. vermicularis was greater in children with onychophagia (OR = 1.6, 95% IC: 0.7–3.7) and in 6 year olds and older whose parents completed only primary studies (OR = 3.6, 95% IC: 1.4–9.1). The results obtained show the existence of a worrying epidemiological scenario that stresses the importance of zoonotic parasitosis as a serious problem of public health.
Neurocognitive performances of visuospatial attention and the correlations with metabolic and inflammatory biomarkers in adults with obesity
Authors: Tsai Chia‐Liang , Huang Tsang‐Hai , Tsai Meng‐Che 
Published: October 2017

New Findings
What is the central question of this study?
Obesity is linked to cognitive deficits, elevated energy metabolic indices and low‐grade systemic inflammation. Do the relationships between neurocognitive performance and the biochemical markers (e.g. energy metabolic indices and inflammatory cytokines) occur independently of factors known to be associated with neurocognitive dysfunction (i.e. cardiorespiratory fitness) in young adults?

What is the main finding and its importance?
Young obese adults showed poorer neuropsychological performances, aberrant neural activity and higher C‐reactive protein and energy metabolic indices. The higher leptin and C‐reactive protein concentrations showed a significant negative association with lower P3 amplitudes. However, leptin was the sole predictive factor, implicating hyperleptinaemia in the altered neurocognitive function observed in obesity.

The present study was designed to explore the neurophysiological mechanism of visuospatial attention deficits in obese adults and to examine the relationships between neurocognitive (neuropsychological and neurophysiological) performances and the biochemical markers. Thirty obese adults and 30 healthy‐weight control subjects, categorized by body mass index and percentage fat as measured with dual‐energy X‐ray absorptiometry, provided a fasting blood sample and performed a visuospatial attention protocol with concomitant electrophysiological recording. The obese group showed slower reaction times and smaller P3 amplitudes when performing the cognitive task. Even when controlling for the covariable of cardiorespiratory fitness, the results remained. In addition, the serum concentrations of insulin, glucose, leptin and C‐reactive protein were significantly higher in the obese group relative to the control group, but not those of interleukin‐6, interleukin‐1β and tumour necrosis factor‐α. Partial correlations adjusting for cardiorespiratory fitness showed that leptin and C‐reactive protein concentrations in the obese group were negatively associated with poorer neurophysiological (i.e. P3 amplitude) performance. However, the regression analysis showed that leptin was the sole predictor of P3 amplitude in the obese group. These findings indicate that the individuals with obesity exhibited neurocognitive deficits when performing the visuospatial attention task, and serum leptin concentrations could be one of the influential factors.
Sport Participation for Elite Athletes With Physical Disabilities: Motivations, Barriers, and Facilitators
Authors: McLoughlin Gabriella , Weisman Fecske Courtney , Castaneda Yvette , Gwin Candace , Graber Kim 
Published: October 2017

There are many reasons why individuals are motivated to participate in sports. Less attention, however, is given for studying motivation and athlete development in adapted sport. The purpose of this study was to identify the motivations, facilitators, and barriers to sports participation of elite athletes with a physical disability. Participants (N = 23, 17 males, six females, mean age: 24.3 years) were recruited through online listservs, e-mails, and snowball sampling. A semistructured interview guide was employed. Analysis was conducted and grounded in self-determination theory and literature surrounding barriers and facilitators of sports participation. Through coding by multiple researchers, six themes emerged. Themes indicated that athletes attributed participation to constructs of self-determination theory as well as overcoming specific barriers such as cost, time constraints, and lack of opportunity. Among facilitators to their athletic development, there were empowerment and advocacy, increased health, college scholarships, and achieving performance-related goals.
Metalenses: Versatile multifunctional photonic components
Authors: Khorasaninejad Mohammadreza , Capasso Federico 
Published: October 2017

Looking sharp with metalenses
High-end imaging lenses have tended to be based on bulk optical components. Advances in fabrication techniques have enabled the development of ultrathin, lightweight, and planar lenses (metalenses) that have unprecedented functionalities. These metalenses have the potential to replace or complement their conventional bulk counterparts. Khorasaninejad and Capasso review the evolution of metalenses, summarizing achievements and applications and identifying future challenges and opportunities. Metalenses can have numerous applications, ranging from cellphone camera modules, to wearable displays for augmented and virtual reality and machine vision, to bio-imaging and endoscopy.

Science
, this issue p.
eaam8100
Draft Genome Sequences of Two Uncultured
Armatimonadetes
Associated with a
Microcystis
sp. (
Cyanobacteria
) Isolate
Authors: Woodhouse Jason N. , Makower A. Katharina , Grossart Hans-Peter , Dittmann Elke 
Published: October 2017

ABSTRACT

Two genome sequences of the phylum
Armatimonadetes
, derived from terrestrial environments, have been previously described. Here, two additional
Armatimonadetes
genome sequences were obtained via single-molecule real-time (SMRT) sequencing of an enrichment culture of the bloom-forming cyanobacterium
Microcystis
sp. isolated from a eutrophic lake (Brandenburg, Germany). The genomes are most closely affiliated with the class
Fimbriimonadales
, although they are smaller than the 5.6-Mbp type strain genome.
Complete Genome Characterization of Novel Chinese Porcine Deltacoronavirus Strain SD
Authors: Liu Can , Zhang Xing , Zhang Ziqi , Chen Rui , Zhang Zhigang , Xue Qinghong 
Published: October 2017

ABSTRACT
A porcine deltacoronavirus (PDCoV) was isolated and identified from feces of diarrheic piglets in Shandong Province of the Chinese mainland, and the complete genome of the Chinese PDCoV strain, SD, was sequenced and analyzed to further characterize PDCoV circulating in China.
Draft Genome Sequence of Gordonia lacunae BS2
T
Authors: Durrell Kim , Prins Alaric , Le Roes-Hill Marilize 
Published: October 2017

ABSTRACT

We report here the draft genome sequence of the soil bacterium
Gordonia lacunae
BS2
T
(= DSM 45085
T
= JCM 14873
T
= NRRL B-24551
T
), isolated from an estuary in Plettenberg Bay, South Africa. Analysis of the draft genome revealed that more than 40% of the secondary metabolite biosynthetic genes encode new compounds.
Draft Genome Sequence of Pseudomonas stutzeri Strain KMS 55, an Endophytic Diazotroph Isolated from Rice Roots
Authors: Annapurna Kannepalli , Govindasamy Venkadasamy , Sharma Meenakshi , Rajrana Yuvika , Swarnalakshmi Karivaradharajan , Paul Sangeeta , Ghosh Arpita , Chikara Surendra K. 
Published: October 2017

ABSTRACT

Pseudomonas stutzeri
strain KMS 55 (MTCC 12703) is an isolate from the root tissues of rice (
Oryza sativa
L.) that displays a high biological nitrogen fixation ability. Here, we report the complete genome sequence of this strain, which contains 4,637,820 bp, 4,289 protein-coding genes, 5,006 promoter sequences, 62 tRNAs, a single copy of 5S-16S-23S rRNA, and a genome average GC content of 51.18%. Analysis of the ~4.64-Mb genome sequence will give support to increased understanding of the genetic determinants of host range, endophytic colonization behavior, endophytic nitrogen fixation, and other plant-beneficial roles of
Pseudomonas stutzeri
.
Draft Genome Sequence of Methylobacterium radiotolerans Strain MAMP 4754, a Bacterial Endophyte Isolated from
Combretum erythrophyllum
in South Africa
Authors: Photolo Mampolelo M. , Mavumengwana Vuyo , Serepa-Dlamini Mahloro H. , Tlou Matsobane G. 
Published: October 2017

ABSTRACT

We announce here the draft genome sequence of
Methylobacterium radiotolerans
strain MAMP 4754, isolated from the roots of the medicinal plant
Combretum erythrophyllum
.
M. radiotolerans
has a genome size of 7,389,282 bp with 7,166 genes and a G+C content of 70.5%.
Draft Genome Sequence of the Type Strain Aeromonas salmonicida subsp.
salmonicida
ATCC 33658
Authors: Valderrama Katherinne , Soto-Davila Manuel , Santander Javier 
Published: October 2017

ABSTRACT

Here, we report the draft genome sequence of the type strain
Aeromonas salmonicida
subsp.
salmonicida
ATCC 33658 isolated from
Salmo salar
. The size of the genome is 4,728,143 bp with a G+C content of 58.5%. The
A. salmonicida
subsp.
salmonicida
ATCC 33658 genome lacks essential virulence genes that were likely lost during genomic rearrangements.
Draft Genome Sequence Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in 2013 from Humans and Chickens in Nigeria
Authors: Sharma Poonam , Gupta Sushim K. , Adenipekun Eyitayo O. , Barrett John B. , Hiott Lari M. , Woodley Tiffanie A. , Iwalokun Bamidele A. , Oyedeji Kolawole S. , Oluwadun Afolabi , Ramadan Hazem , Frye Jonathan G. , Jackson Charlene R. 
Published: October 2017

ABSTRACT

Here, we present the draft genome sequences of nine multidrug-resistant
Escherichia coli
strains isolated from humans (
n
= 6) and chicken carcasses (
n
= 3) from Lagos, Nigeria, in 2013. Multiple extended-spectrum β-lactamase (ESBL) genes were identified in these isolates.
Complete Genome Sequences of the Plant Pathogens Ralstonia solanacearum Type Strain K60 and R. solanacearum Race 3 Biovar 2 Strain UW551
Authors: Hayes Madeline M. , MacIntyre April M. , Allen Caitilyn 
Published: October 2017

ABSTRACT

Ralstonia solanacearum
is a globally distributed plant pathogen that causes bacterial wilt diseases of many crop hosts, threatening both sustenance farming and industrial agriculture. Here, we present closed genome sequences for the
R. solanacearum
type strain, K60, and the cool-tolerant potato brown rot strain
R. solanacearum
UW551, a highly regulated U.S. select agent pathogen.
Complete Genome Coding Sequences of Artashat, Burana, Caspiy, Chim, Geran, Tamdy, and Uzun-Agach Viruses (
Bunyavirales
:
Nairoviridae
:
Orthonairovirus
)
Authors: Alkhovsky Sergey V. , Lvov Dmitry K. , Shchetinin Alexey M. , Deriabin Petr G. , Shchelkanov Mikhail Y. , Aristova Valeriya A. , Morozova Tatyana N. , Gitelman Asya K. , Palacios Gustavo F. , Kuhn Jens H. 
Published: October 2017

ABSTRACT

The bunyaviral monogeneric family
Nairoviridae
currently includes 12 species for 35 distinct viruses. Here, we present the complete genome coding sequences of an additional seven nairoviruses. Five of them can be assigned to established species, whereas two of them (Artashat and Chim viruses) ought to be assigned to two novel species.
Closed Genome Sequences of Seven Histophilus somni Isolates from Beef Calves with Bovine Respiratory Disease Complex
Authors: Harhay Gregory P. , Harhay Dayna M. , Bono James L. , Smith Timothy P. L. , Capik Sarah F. , DeDonder Keith D. , Apley Michael D. , Lubbers Brian V. , White Bradley J. , Larson Robert L. 
Published: October 2017

ABSTRACT

Histophilus somni
is a fastidious Gram-negative opportunistic pathogenic
Pasteurellaceae
that affects multiple organ systems and is one of the principal bacterial species contributing to bovine respiratory disease complex (BRDC) in feed yard cattle. Here, we present seven closed genome sequences isolated from three beef calves showing sign of BRDC.
Complete Genome Sequences of Weissella cibaria Strains CMU, CMS1, CMS2, and CMS3 Isolated from Infant Saliva in South Korea
Authors: Kang Mi-Sun , Yeu Ji-Eun , Oh Jong-Suk , Shin Boo-Ahn , Kim Jin-Hee 
Published: October 2017

ABSTRACT

Weissella cibaria
strain CMU is used as a commercial oral care probiotic in South Korea. Here, we present the complete genome sequences of four
W. cibaria
strains (CMU, CMS1, CMS2, and CMS3) isolated from the saliva of an infant living in Gwangju, South Korea.
Complete Genomic Sequence of Dengue Virus Serotype 4 Isolated from Plasma Collected from a Haitian Child in 2014
Authors: Elbadry Maha A. , White Sarah K. , Loeb Julia C. , Tagliamonte Massimiliano S. , Salemi Marco , Beau De Rochars Valery Madsen , Telisma Taina , Rashid Mohammed , Morris J. Glenn , Lednicky John A. 
Published: October 2017

ABSTRACT
While data are limited, there is increasing evidence that infections by dengue viruses are endemic in Haiti. In 2014, an outbreak caused by dengue virus 4 (DENV-4) followed a chikungunya fever outbreak. We present here the complete genome sequence of one isolate grouped within the genotype II South America and Caribbean DENV-4 clades.
Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma
Authors: Siah We Fong , O’Brien Colm , Loughman James J 
Published: October 2017

AimTo evaluate the relationship between macular pigment optical density (MPOD) and glare disability in open-angle glaucoma.MethodsA cross-sectional analysis of baseline data (88 subjects; median age, 67 (range 36–84) years) collected during the Macular Pigment and Glaucoma Trial (ISRCTN registry number: 56985060). MPOD at 0.25°, 0.5° and 1° of retinal eccentricity was measured using customised heterochromatic flicker photometry. Mesopic contrast sensitivity with glare (mCSg), photostress recovery time (PRT) and self-reported glare symptoms were evaluated. Fourier-domain optical coherence tomography was used to analyse ganglion cell complex (GCC) and identify foveal involvement.ResultsLow spatial frequency (f) mCSg was significantly correlated with MPOD at 0.25°(3 cycles per degree (cpd): r=0.25, p=0.04) and 0.5° (3 cpd: r=0.23, p=0.04) of retinal eccentricity. Those with foveal GCC loss exhibited lower MPOD, had worse low spatial fmCSg (1.5 cpd and 3 cpd, p=0.02 each) and prolonged PRT (p=0.02) in comparison with those without foveal involvement. The depth of central 10° field loss was related to MPOD at all eccentricities (p<0.01 for all). Those who reported glare symptoms had a significantly lower MPOD at all retinal eccentricities (0.25° and 1°: p=0.05 each; 0.5°: p=0.04), including those with foveal involvement (0.25°: p=0.05; 0.5°: p<0.01; 1°: p=0.01).ConclusionsMacular pigment level may be an important consideration among those experiencing disability glare in glaucoma, including those with foveal involvement.Trial registration numberISRCTN56985060, Post-results.
In vitro synergy of natamycin and voriconazole against clinical isolates of Fusarium, Candida, Aspergillus and Curvularia spp
Authors: Sradhanjali Swatishree , Yein Bandana , Sharma Savitri , Das Sujata 
Published: October 2017

AimTo determine the minimum inhibitory concentrations (MICs) of voriconazole and natamycin, alone and in combination, against the clinical isolates of Fungus and to evaluate the synergy between the drugs in an experimental in vitro study.MethodsIn an experimental in vitro study, clinical isolates of Fusarium, Aspergillus, Candida and Curvularia spp were maintained on Sabouraud Dextrose Agar and used for the study. The MICs of natamycin and voriconazole, used alone and in combination, were evaluated by checkerboard microdilution technique based on the standard protocol proposed by the Clinical Laboratory Standards Institute. The interactions were assessed using the fractional inhibitory concentration (FIC) Index model.ResultsTested with all the clinical isolates, the MICs ranged between 0.125 and 8 µg/mL both for natamycin and voriconazole. In descending order, maximum synergism (FIC ≤0.5) was observed in Candida spp (33.3%) followed by Curvularia spp and Fusarium spp (23.1%). Synergism was least for Aspergillus spp (22.2%). However, at 61.5% (8/13), maximum additive effect (>0.5–1) was observed in Aspergillus spp and minimum (33.3%, 2/6) in Candida spp. Indifference (FIC value >1 and≤4) was observed in 22.2% (2/9) of Aspergillus spp, 15.4% (2/13) of Fusarium spp, 33.3% (2/6) of Candida spp and 23.1% (3/13) of Curvularia spp. No cases of antagonism (FIC >4) were observed.ConclusionsNatamycin and voriconazole in combination demonstrated more effective antifungal activity than single-use in vitro treatment in all species tested, which implies that these combinations may be helpful in treating fungal keratitis. There was no antagonism between these two drugs.