bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Stepped Care Model in Delivering Primary Mental Health Services—A Scoping Review
Authors: Mareya Shingai , Watts Mimmie Claudine , Zhao Lin , Olasoji Michael 
Published: September 2024

ABSTRACTThe stepped care model (SCM) is a patient‐centred approach to mental health care, offering a range of services from least to most intensive, tailored to individual needs. This scoping review examines the adoption, effectiveness, challenges and implications associated with applying SCM within primary mental health service delivery. Evidence from global sources suggests the model is viable, effective and useful. This review explores the literature available, clarifies fundamental concepts and identifies existing knowledge gaps. The literature search included CINAHL, MEDLINE, PsycINFO, Scopus, the Federation University library, Google and Google Scholar databases. A systematic keyword‐based search using terms like “stepped care model,” “mental health,” and “primary care”; and a combination of keywords and subject headings, were used. The search strategy was refined by considering factors such as relevance, publication date, objectives and outcomes. This strategy yielded 20 papers compiled in this review. They include randomised controlled trials and cross‐sectional studies. The review supports SCM adoption in primary mental health care but acknowledges the need for further research. Key inclusions of the review include cost‐effectiveness, diverse diagnoses, efficacy and the model's structural configuration. Clear treatment details, delivery methods, intervention durations and chronological sequences are essential. This systematic approach enhances generalisability across different SCM models and areas, strengthening reliable inferences. In summary, the SCM holds promise for enhancing mental health service delivery. However, there is a need to further examine the factors that determine its effectiveness and understand the different ways in which SCM is implemented. Such inquiry forms the foundation for implementing and advancing mental health care services in Australia and internationally.
Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system
Authors: He Yuhong , Wang Ke , Su Niri , Yuan Chongshan , Zhang Naisheng , Hu Xiaoyu , Fu Yunhe , Zhao Feng 
Published: September 2024

AbstractAlong with mounting evidence that gut microbiota and their metabolites migrate endogenously to distal organs, the ‘gut–lung axis,’ ‘gut–brain axis,’ ‘gut–liver axis’ and ‘gut–renal axis’ have been established. Multiple animal recent studies have demonstrated gut microbiota may also be a key susceptibility factor for neurological disorders such as Alzheimer's disease, Parkinson's disease and autism. The gastrointestinal tract is innervated by the extrinsic sympathetic and vagal nerves and the intrinsic enteric nervous system, and the gut microbiota interacts with the nervous system to maintain homeostatic balance in the host gut. A total of 1507 publications on the interactions between the gut microbiota, the gut–brain axis and neurological disorders are retrieved from the Web of Science to investigate the interactions between the gut microbiota and the nervous system and the underlying mechanisms involved in normal and disease states. We provide a comprehensive overview of the effects of the gut microbiota and its metabolites on nervous system function and neurotransmitter secretion, as well as alterations in the gut microbiota in neurological disorders, to provide a basis for the possibility of targeting the gut microbiota as a therapeutic agent for neurological disorders.
Oceanic whitetip shark cookies: Evidence of multiple predation events by an opportunistic mesopelagic predator on a large epipelagic shark
Authors: Cardeñosa Diego 
Published: September 2024

AbstractIn June 2024, a large female oceanic whitetip shark (Carcharhinus longimanus) was observed near San Andres Island, Colombia, bearing at least 41 healed circular scars on its skin. These scars, resembling those left by cookiecutter sharks on large teleost species, suggest repeated predation events. Cookiecutter sharks typically leave one or two bite marks per prey item, with a small percentage showing five or more marks. The observation implies frequent depth overlap between the mesopelagic cookiecutter sharks and the epipelagic oceanic whitetip shark in the Caribbean Sea.
Efficacy and Tolerability of a Novel Cosmetic and Over‐the‐Counter Facial Acne Regimen Versus a Prescription Treatment
Authors: Huang Priscilla , Supan Olivia , Pak Cecilia L. , Mehta Rahul C. , Makino Elizabeth T. 
Published: September 2024

ABSTRACTBackgroundThe SkinMedica Acne Treatment Platform (SM Regimen) was formulated to treat acne without overdrying the skin. We evaluated efficacy and tolerability of the SM Regimen (including a novel 1% salicylic acid Acne Clarifying Cleanser and 2% salicylic acid Acne Treatment Lotion) versus a prescription formulation (Rx Regimen; including adapalene 0.1%/benzoyl peroxide 2.5%) in a diverse population of adults with mild to moderate facial acne.MethodsThis single‐center, double‐blind, randomized study enrolled adults (18–45 years) with Fitzpatrick skin types (FST) I–VI. SM Regimen or Rx Regimen was applied topically to the entire face for 12 weeks. Assessments were conducted at 24 and 48 h and 4, 8, and 12 weeks.ResultsSubjects (SM Regimen, n = 31; Rx Regimen, n = 23) were primarily female (90.7%) with mean age of 28.6 years; 53.8% had FST IV–VI. Efficacy was comparable between regimens. The SM regimen resulted in significant improvements versus baseline in mean Investigator's Global Assessment of acne severity from 48 h through week 12 (p ≤ 0.001), as well as significant and sustained improvements from baseline in total acne lesion count, global postinflammatory hyperpigmentation/postinflammatory erythema, and oiliness. The SM Regimen was well tolerated at all time points, with mean scores below mild for all parameters; the Rx Regimen caused significantly more tightness/dry feeling at week 4 versus SM Regimen (p = 0.008). Subjects (> 96%) reported high satisfaction with the SM Regimen at all time points.ConclusionsThe SM Regimen reduced acne severity and skin oiliness, evening out skin tone without overdrying or irritating the skin.
Human performance in predicting enhancement quality of gliomas using gadolinium‐free MRI sequences
Authors: Azizova Aynur , Wamelink Ivar J. H. G. , Prysiazhniuk Yeva , Cakmak Marcus , Kaya Elif , Petr Jan , Barkhof Frederik , Keil Vera C. 
Published: September 2024

AbstractBackground and PurposeTo develop and test a decision tree for predicting contrast enhancement quality and shape using precontrast magnetic resonance imaging (MRI) sequences in a large adult‐type diffuse glioma cohort.MethodsPreoperative MRI scans (development/optimization/test sets: n = 31/38/303, male = 17/22/189, mean age = 52/59/56.7 years, high‐grade glioma = 22/33/249) were retrospectively evaluated, including pre‐ and postcontrast T1‐weighted, T2‐weighted, fluid‐attenuated inversion recovery, and diffusion‐weighted imaging sequences. Enhancement prediction decision tree (EPDT) was developed using development and optimization sets, incorporating four imaging features: necrosis, diffusion restriction, T2 inhomogeneity, and nonenhancing tumor margins. EPDT accuracy was assessed on a test set by three raters of variable experience. True enhancement features (gold standard) were evaluated using pre‐ and postcontrast T1‐weighted images. Statistical analysis used confusion matrices, Cohen's/Fleiss’ kappa, and Kendall's W. Significance threshold was p < .05.ResultsRaters 1, 2, and 3 achieved overall accuracies of .86 (95% confidence interval [CI]: .81‐.90), .89 (95% CI: .85‐.92), and .92 (95% CI: .89‐.95), respectively, in predicting enhancement quality (marked, mild, or no enhancement). Regarding shape, defined as the thickness of enhancing margin (solid, rim, or no enhancement), accuracies were .84 (95% CI: .79‐.88), .88 (95% CI: .84‐.92), and .89 (95% CI: .85‐.92). Intrarater intergroup agreement comparing predicted and true enhancement features consistently reached substantial levels (≥.68 [95% CI: .61‐.75]). Interrater comparison showed at least moderate agreement (group: ≥.42 [95% CI: .36‐.48], pairwise: ≥.61 [95% CI: .50‐.72]). Among the imaging features in the EPDT, necrosis assessment displayed the highest intra‐ and interrater consistency (≥.80 [95% CI: .73‐.88]).ConclusionThe proposed EPDT has high accuracy in predicting enhancement patterns of gliomas irrespective of rater experience.
Incidence and presenting features of paediatric type 1 diabetes mellitus and diabetic ketoacidosis in a regional Australian health service
Authors: Cousen Shaun , Hiskens Matthew , Signal Dana , Vangaveti Venkat , Hariharan Gopakumar 
Published: September 2024

AimTo determine the incidence and presenting features of type 1 diabetes mellitus and diabetic ketoacidosis in a paediatric population serviced by a regional health service in Queensland, Australia.MethodsAll patients less than 16 years old diagnosed with type 1 diabetes mellitus between 01 January 2015 and 31 December 2021 were included in this retrospective, observational study. The electronic medical records of each patient were reviewed to collect data on demographics, presentation and ongoing diabetes care.ResultsSixty‐four paediatric patients were diagnosed with type 1 diabetes mellitus during the study period, giving an incidence of 25 cases per 100 000 person years. Half the patients presented with diabetic ketoacidosis, with 14 (22% of the total cohort) presenting in severe diabetic ketoacidosis. There was no significant increase in the incidence of type 1 diabetes mellitus or proportion of patients with diabetic ketoacidosis across the years of the study. Patients that had a delayed diagnosis had an increased likelihood of presenting with severe diabetic ketoacidosis.ConclusionIncidence of type 1 diabetes mellitus in the paediatric population in this regional centre in Queensland, Australia, is similar to national data. High proportions of patients presenting with diabetic ketoacidosis and severe diabetic ketoacidosis were identified in the study population, with delayed diagnosis, a risk factor for severe diabetic ketoacidosis.
Interpretation of Sydney Swallow Questionnaire results using the oropharyngeal dysphagia risk matrix
Authors: Audag Nicolas , Toussaint Michel , Prigent Hélène , Reychler Gregory 
Published: September 2024

AbstractBackgroundOropharyngeal dysphagia (OD) commonly occurs in neuromuscular diseases (NMD). Appropriate management involves early detection, clinical evaluation, and tailored follow‐up to minimize complications. Various assessment tools exist, including the Sydney Swallow Questionnaire (SSQ), a patient‐reported outcome measure for assessing OD severity in adult patients. This paper proposes utilizing an innovative risk matrix (OD‐Risk‐Matrix) to enhance SSQ interpretation. This matrix categorizes OD risk for each SSQ question, offering valuable assistance to clinicians.MethodsThis study analyzes SSQ results from a cohort of individuals with NMD (n = 57). Patients filled in the SSQ during outpatient visits at our neuromuscular center. Subsequently, SSQ scores were grouped by NMD conditions and interpreted using the OD‐Risk‐Matrix categorizing each question's risk as low, moderate, or high. This matrix is based on the SSQ results by categorizing the risk of OD for each question, as well as the likelihood of occurrence of OD.Key ResultsIn light of the OD‐Risk‐Matrix, the interpretation of SSQ scores revealed various risk categories associated with each question, while also highlighting distinct OD characteristics and discrepancies among the different NMDs.Conclusion and InferencesIn conclusion, the OD‐Risk‐Matrix offers a framework for interpreting the SSQ, revealing variations in the risks of OD among different questions in patients with NMD. This novel approach could be a valuable tool in SSQ interpretation to identify specific fields of OD and could lead to a tailored management plan, prioritizing interventions aimed at reducing the risk of aspiration, ensuring proper nutrition, and enhancing swallowing safety and efficiency.
The enigmatic Triassic ovulate reproductive structures of Dordrechtites are recurved cupules fundamentally comparable to the cupules of Doylea and similar plants
Authors: Crane Peter R. , Anderson John M. , Anderson Heidi , Herendeen Patrick S. , Herrera Fabiany 
Published: September 2024

Summary

Recent paleobotanical discoveries have renewed interest in the distinctively recurved, seed‐bearing cupules of Mesozoic plants, which are important for understanding seed plant phylogeny and the origin of the second integument of the angiosperm ovule.

Reanalysis of the enigmatic seed‐bearing organ Dordrechtites elongatus from the Triassic of South Africa, the type species of the genus, combined with information from similar material from Antarctica, Argentina and Australia, indicates that Dordrechtites is a highly modified lateral branch of a seed cone. Short lateral projections from a primary cone axis each bear several Dordrechtites units. Each unit consists of a long stalk bearing a straight to sometimes recurved cupule with a long distal extension beyond the cupule apex. Each cupule is flattened in a plane perpendicular to the stalk and distal projection and contains up to two seeds.

Structural similarities between Dordrechtites and the cupules of Doyleales indicate that they are homologous, providing new evidence for a close relationship.

The persistent cupule stalk and apical extension of Dordrechtites, combined with the flattened cupule, suggests modification for wind and water dispersal.
Genetic and transcriptomic analysis of the BradyrhizobiumT3SS‐triggered nodulation in the legume Aeschynomene evenia
Authors: Camuel Alicia , Gully Djamel , Pervent Marjorie , Teulet Albin , Nouwen Nico , Arrighi Jean‐François , Giraud Eric 
Published: September 2024

Summary

Some Bradyrhizobium strains nodulate certain Aeschynomene species independently of Nod factors, but thanks to their type III secretion system (T3SS). While different T3 effectors triggering nodulation (ErnA and Sup3) have been identified, the plant signalling pathways they activate remain unknown.

Here, we explored the intraspecies variability in T3SS‐triggered nodulation within Aeschynomene evenia and investigated transcriptomic responses that occur during this symbiosis. Furthermore, Bradyrhizobium strains having different effector sets were tested on A. evenia mutants altered in various symbiotic signalling genes.

We identified the A. evenia accession N21/PI 225551 as appropriate for deciphering the T3SS‐dependent process. Comparative transcriptomic analysis of A. evenia N21 roots inoculated with ORS3257 strain and its ∆ernA mutant revealed genes differentially expressed, including some involved in plant defences and auxin signalling. In the other A. evenia accession N76, all tested strains nodulated the AeCRK mutant but not the AeNIN and AeNSP2 mutants, indicating a differential requirement of these genes for T3SS‐dependent nodulation. Furthermore, the effects of AePOLLUX, AeCCaMK and AeCYCLOPS mutations differed between the strains. Notably, ORS86 nodulated these three mutant lines and required for this both ErnA and Sup3.

Taken together, these results shed light on how the T3SS‐dependent nodulation process is achieved in legumes.
IRON AGE LEVANTINE POLITIES AND THEIR MATERIAL CULTURE, WITH A CASE STUDY FROM TEL REḤOV, NORTHERN ISRAEL
Authors: Sergi Omer 
Published: September 2024

SummaryThe following article deals with the possible association of political entities with specific material culture. By referring to a test case from the southern Levant – that of Late Iron IIA (late tenth–ninth centuries BC) Tel Reḥov and its political affiliation within the context of the regional settlement system, this article discusses the methodological caveats and prospects pertinent in any attempt to archaeologically identify political entities. It further demonstrates how settlement patterns and material culture may reveal the underlying social complexity of the Iron Age Levantine territorial polities, and the ways in which political hegemony was practised among diverse communities.
“They don't care what we watch”: On ratings and culture‐making in the dizi industry
Authors: Sertbulut Zeynep 
Published: September 2024

AbstractThis article challenges Western‐centric assumptions in existing media theories that assume a relatively democratic society by exploring the media worlds of dizis, Turkey's globally famous, serialized television melodramas. It examines dizi makers' frustrations with a recently revised rating system at a time when Turkey's conservative and authoritarian‐leaning ruling AKP elite increasingly intervene in the country's cultural field. The article argues that in Turkey's highly polarized, authoritarian context, ratings become a crucial site of culture‐making, through which Turkish culture, the value of cultural products like dizis, and the place of their creators in Turkey's cultural hegemony get renegotiated. Exploring the resentments of today's dizi makers reveals that contemporary Turkish power contestations cannot be reduced to either the secular/religious binary or to class dynamics alone, as often deployed to explain the current polarization between Erdoğan's supporters and his dissidents. The article also demonstrates the need for more rigorous theorizing about how states—as repressive actors in authoritarian contexts—affect the worlds of media creators and their works.
Control of action potential afterdepolarizations in the inferior olive by inactivating A‐type currents through KV4 channels
Authors: Sultan Ziyad W. , Najac Marion , Raman Indira M. 
Published: September 2024

AbstractNeurons of the inferior olive (IO) fire action potentials with large, long‐lasting afterdepolarizations (ADPs). Broader ADPs support more spikes in climbing fibre axons and evoke longer bursts of complex spikes in Purkinje cells, which affect the magnitude and sign of cerebellar synaptic plasticity. In the present study, we investigated the ionic mechanisms that regulate IO action potential waveforms by making whole‐cell recordings in brainstem slices from C57BL6/J mice. IO spikes evoked from rest had ADPs of ∼30 ms. After 500‐ms hyperpolarizations, however, evoked action potentials were brief (1–2 ms), lacking ADPs altogether. Because such preconditioning should maximally recruit depolarizing Ih and T‐type currents and minimize repolarizing Ca‐dependent currents known to shape the ADP, the rapid action potential downstroke suggested additional, dominant recovery of voltage‐gated K currents at negative voltages. Under voltage clamp, outward currents evoked from –98 mV included large, voltage‐gated, rapidly inactivating ‘A‐type’ K currents. These currents had a steep availability curve with half‐inactivation at –85 mV, suitable for recruitment by small hyperpolarizations. The fast decay time constant increased with depolarization, as is typical of KV4 channels. The KV4 channel blocker AmmTx3 almost eliminated inactivating currents and broadened action potentials evoked from strongly negative potentials by ∼8‐fold. Optogenetic stimulation of inhibitory cerebellar nucleo‐olivary terminals hyperpolarized IO cells sufficiently to abolish the ADP. The data support the idea that currents through KV4 channels control action potential waveforms in IO cells, shortening ADPs during synaptic inhibition or troughs of membrane potential oscillations, thereby controlling the number of climbing fibre action potentials that propagate to the cerebellum.
imageKey points
Neurons in the mouse inferior olive (IO) express a large, inactivating, voltage‐gated A‐type K current carried by KV4 channels.
IO action potentials evoked from rest have large, long afterdepolarizations that disappear with pre‐spike hyperpolarizations of 5–15 mV.
The steep voltage‐sensitivity and rapid recovery of KV4 channels regulates the duration of the afterdepolarization over more than one order of magnitude.
Factors such as synaptic inhibition are sufficient to recruit KV4 channels and eliminate afterdepolarization (ADP).
By controlling the ADP, KV4 channels can set the number of climbing fibre action potentials relayed to the cerebellum and regulate plasticity implicated in motor learning.
Numerical Study on Thermal Storage-Discharge Process of Envelopes in Building Heating Systems With Different Terminals
Authors: Xu Baoping , Zhang Hengrui , Dou Yanzhe , Zheng Xiaofeng , Yan Yuying 
Published: September 2024

Abstract
Building clusters and district heating systems have large thermal inertia, which can serve as thermal storage units and regard as important flexible resource. In this study, an integrated spatial discrete model for simulating the thermal performance of the envelopes in building heating systems is developed The model is applied to simulate the thermal behavior of building envelopes, indoor air and heating terminals, and time constant of heat release processes are defined to characterize the flexibility potential of passive thermal storage units in building heating systems. The simulation results indicate that the thermal storage units in building heating systems related to a muti-time scale problem. The time constants for the heat storage units in heating systems with different terminals are different. During the heat release process, the time constant for radiator heating system reaches 180h–250h, the time constant fan coil heating system reaches 100h–150h. The time constant of heat release from walls in buildings is more than 120h. In the case of fan coil heating, the rate of increase of both room and wall temperatures is greater than in the case of radiator heating systems. The results of this study provide further data for developing better DR control strategies for heating systems with different building envelopes and heating terminals.
Ballistic-Diffusive Phonon Transport and Anderson Localization in Aromatic-Ring Single-Molecule Junctions
Authors: Hua Renjie , Gu Xiaogeng , Huang Zhiyuan , Dong Yuan 
Published: September 2024

Abstract
We studied the cross-interface heat conduction in a nanodiamond-molecule-carbon nanotube heterostructure by nonequilibrium molecular dynamics simulations, where single-molecule junction is an asymmetric molecular structure of p-phenylenes with NH-C=O as the anchoring group. We found an interesting phenomenon that when the number of phenyls is odd (i.e. n = 1, 3, and 5), interfacial thermal conductance increases with temperature increasing from 100 K to 400 K, and then decreases after temperature greater than 400 K. When the number of phenyls is even (i.e. n = 2, 4, and 6), the interfacial thermal conductance as a function of temperature displays an overall increasing trend in the range 100 to 500 K. Temperature dependence indicates the disordered feature of single-molecule junction in heterojunction systems. The length dependence reveals the ballistic-diffusive phonon transport through single-molecule junctions. Interfacial phonon modes bridge the phonon transport between the dissimilar functional groups, which demonstrate the relationship between phonon localization and other phonons at the interface. Our observations open new perspectives to understand the heat conduction across single-molecule junctions in heterostructure systems and may provide theoretical assistance to applications of phonon engineering in single-molecule electronic devices and electronics thermal management.