bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of penetrating keratoplasty in congenital hereditary endothelial dystrophy
Authors: AlArrayedh Hamed , Collum Louis , Murphy Conor C 
Published: May 2017

Background/aimTo report the outcome of penetrating keratoplasty (PKP) in Irish patients with congenital hereditary endothelial dystrophy (CHED).MethodsA retrospective case series review of patients with CHED who underwent PKP was conducted. The outcomes of PKP in 14 patients with CHED at the Royal Victoria Eye and Ear Hospital in Dublin from 1978 to 2013 were described following case note review. The main outcome measures were best-corrected visual acuity (BCVA) and graft survival.ResultsThirty-three corneal transplants were performed, which included 32 PKPs and one Descemet’s stripping endothelial keratoplasty. Twenty-four eyes underwent primary corneal grafts and nine eyes had regrafts. The graft survival rates at final follow-up were 37.5% and 33% in the primary graft and regraft groups, respectively. Preoperative BCVA was 20/200 or worse in all patients. At the final postoperative visit, the BCVA was 20/80 or better in four eyes following primary PKP, 20/160 in one eye following regrafting and was 20/200 or worse in all other eyes. The mean time to graft failure was 16 months (range 0–37 months). The mean follow-up time was 101 months (range 12–252 months). Fifty per cent of the patients continue to attend for follow-up.ConclusionsThis study has demonstrated a poor outcome from PKP for CHED in this Irish cohort. This arises from a combination of dense amblyopia and a high risk of graft failure in the long term.
Copenhagen Airport Cohort: air pollution, manual baggage handling and health
Authors: Møller Karina Lauenborg , Brauer Charlotte , Mikkelsen Sigurd , Loft Steffen , Simonsen Erik B , Koblauch Henrik , Bern Stine Hvid , Alkjær Tine , Hertel Ole , Becker Thomas , Larsen Karin Helweg , Bonde Jens Peter , Thygesen Lau Caspar 
Published: May 2017

PurposeCopenhagen Airport Cohort 1990–2012 presents a unique data source for studies of health effects of occupational exposure to air pollution (ultrafine particles) and manual baggage handling among airport employees. We describe the extent of information in the cohort and in the follow-up based on data linkage to the comprehensive Danish nationwide health registers. In the cohort, all information is linked to the personal identification number that also is used in Denmark Statistics demographic and socioeconomic databases and in the nationwide health registers.ParticipantsThe cohort covers 69 175 men in unskilled positions. The exposed cohort includes men in unskilled jobs employed at Copenhagen Airport in the period 1990–2012 either as baggage handlers or in other outdoor work. The reference cohort includes men in unskilled jobs working in the greater Copenhagen area.Findings to dateThe cohort includes environmental Global Positioning System (GPS) measurements in Copenhagen Airport, information on job function/task for each calendar year of employment between 1990 and 2012, exposure to air pollution at residence, average weight of baggage lifted per day and lifestyle. By linkage to registers, we retrieved socioeconomic and demographic data and data on healthcare contacts, drug subscriptions, incident cancer and mortality.Future plansThe size of the cohort and the completeness of the register-based follow-up allow a more accurate assessment of the possible health risks of occupational exposure to ultrafine particles and manual baggage handling at airports than in previous studies. We plan to follow the cohort for the incidence of ischaemic heart diseases, cerebrovascular disease, lung and bladder cancer, asthma and chronic obstructive pulmonary disease, and further for associations between heavy manual baggage handling and musculoskeletal disorders.Trial registrationnumber 2012–41–0199.
Medicine authentication technology as a counterfeit medicine-detection tool: a Delphi method study to establish expert opinion on manual medicine authentication technology in secondary care
Authors: Naughton Bernard , Roberts Lindsey , Dopson Sue , Brindley David , Chapman Stephen 
Published: May 2017

ObjectivesThis study aims to establish expert opinion and potential improvements for the Falsified Medicines Directive mandated medicines authentication technology.Design and interventionA two-round Delphi method study using an online questionnaire.SettingLarge National Health Service (NHS) foundation trust teaching hospital.ParticipantsSecondary care pharmacists and accredited checking technicians.Primary outcome measuresSeven-point rating scale answers which reached a consensus of 70–80% with a standard deviation (SD) of <1.0. Likert scale questions which reached a consensus of 70–80%, a SD of <1.0 and classified as important according to study criteria.ResultsConsensus expert opinion has described database cross-checking technology as quick and user friendly and suggested the inclusion of an audio signal to further support the detection of counterfeit medicines in secondary care (70% consensus, 0.9 SD); other important consensus with a SD of <1.0 included reviewing the colour and information in warning pop up screens to ensure they were not mistaken for the ‘already dispensed here’ pop up, encouraging the dispenser/checker to act on the warnings and making it mandatory to complete an ‘action taken’ documentation process to improve the quarantine of potentially counterfeit, expired or recalled medicines.ConclusionsThis paper informs key opinion leaders and decision makers as to the positives and negatives of medicines authentication technology from an operator's perspective and suggests the adjustments which may be required to improve operator compliance and the detection of counterfeit medicines in the secondary care sector.
Ultrasound for the evaluation of stenosis after flow diversion
Authors: McDougall Cameron M , Khan Khurshid , Saqqur Maher , Jack Andrew , Rempel Jeremy , Derksen Carol , Xi Yin , Chow Michael 
Published: May 2017

Background and purposeFlow diversion is a relatively new strategy used to treat complex cerebral aneurysms. The optimal method for radiographic follow-up of patients treated with flow diverters has not been established. The rate and clinical implications of in-stent stenosis for these devices is unclear. We evaluate the use of transcranial Doppler ultrasound (TCD) for follow-up of in-stent stenosis.Materials and methodsWe analyzed 28 patients treated with the Pipeline embolization device (PED) over the course of 42 months from January 2009 to June 2012. Standard conventional cerebral angiograms were performed in all patients. TCD studies were available in 23 patients.ResultsAngiographic and TCD results were compared and found to correlate well.ConclusionsTCD is a potentially useful adjunct for evaluating in-stent stenosis after flow diversion.
Impact of Fluoropolymer-Based Paclitaxel Delivery on Neointimal Proliferation and Vascular Healing
Authors: Gasior Pawel , Cheng Yanping , Valencia Andres F. , McGregor Jenn , Conditt Gerard B. , Kaluza Grzegorz L. , Granada Juan F. 
Published: May 2017

Background—
A polymer-free peripheral paclitaxel-eluting stent (PES, Zilver PTX, Cook, IN) has shown to improve vessel patency after superficial femoral angioplasty. A new-generation fluoropolymer-based PES (FP-PES; Eluvia, Boston Scientific, MA) displaying more controlled and sustained paclitaxel delivery promise to improve the clinical outcomes of first-generation PES. We sought to compare the biological effect of paclitaxel delivered by 2 different stent-coating technologies (fluoropolymer-based versus polymer-free) on neointimal proliferation and healing response in the familial hypercholesterolemic swine model of femoral restenosis.

Methods and Results—

The biological efficacy of clinically available FP-PES (n=12) and PES (n=12) was compared against a bare metal stent control (n=12; Innova, Boston Scientific, MA) after implantation in the femoral arteries of 18 familial hypercholesterolemic swine. Longitudinal quantitative vascular angiography and optical coherence tomography were performed at baseline and at 30 and 90 days. Histological evaluation was performed at 90 days. Ninety-day quantitative vascular angiography results showed a lower percent diameter stenosis for FP-PES (38.78% [31.27–47.66]) compared with PES (54.16% [42.60–61.97]) and bare metal stent (74.52% [47.23–100.00];
P
<0.001). Ninety-day optical coherence tomography results demonstrated significantly lower neointimal area in FP-PES (8.01 mm
2
[7.65–9.21]) compared with PES (10.95 mm
2
[9.64–12.46]) and bare metal stent (13.83 mm
2
[11.53–17.03];
P
<0.001). Histological evaluation showed larger lumen areas and evidence of higher biological activity (smooth muscle cell loss and fibrin deposition) in the FP-PES compared with PES and bare metal stent.

Conclusions—
In the familial hypercholesterolemic swine model of femoral restenosis, the implantation of an FP-PES resulted in lower levels of neointimal proliferation and sustained biological effect ≤90 days compared with a polymer-free stent-based approach.
On the Definition of Marginal Ice Zone Width
Authors: Strong Courtenay , Foster Dallas , Cherkaev Elena , Eisenman Ian , Golden Kenneth M. 
Published: May 2017

AbstractSea ice features a dense inner pack ice zone surrounded by a marginal ice zone (MIZ) in which the sea ice properties are modified by interaction with the ice-free open ocean. The width of the MIZ is a fundamental length scale for polar physical and biological dynamics. Several different criteria for establishing MIZ boundaries have emerged in the literature—wave penetration, floe size, sea ice concentration, etc.—and a variety of definitions for the width between the MIZ boundaries have been published. Here, three desirable mathematical properties for defining MIZ width are proposed: invariance with respect to translation and rotation on the sphere; uniqueness at every point in the MIZ; and generality, including nonconvex shapes. The previously published streamline definition is shown to satisfy all three properties, where width is defined as the arc length of a streamline through the solution to Laplaces’s equation within the MIZ boundaries, while other published definitions each satisfy only one of the desired properties. When defining MIZ spatial average width from streamline results, the rationale for averaging with respect to distance along both MIZ boundaries was left implicit in prior studies. Here it is made rigorous by developing and applying the mathematics of an analytically tractable idealization of MIZ geometry—the eccentric annulus. Finally, satellite-retrieved Arctic sea ice concentrations are used to investigate how well streamline-based MIZ spatial average width is approximated by alternative definitions that lack desirable mathematical properties or local width values but offer computational efficiency.
Strategies to address the shortcomings of commonly used advanced chronic heart failure descriptors to improve recruitment in palliative care research: A parallel mixed-methods feasibility study
Authors: Kane Pauline M , Murtagh Fliss EM , Ryan Karen R , Brice Mary , Mahon Niall G , McAdam Brendan , McQuillan Regina , O’Gara Geraldine , Raleigh Caroline , Tracey Cecelia , Howley Christine , Higginson Irene J , Daveson Barbara A ,   on behalf of BuildCARE
Published: May 2017

Background: Recruitment challenges contribute to the paucity of palliative care research with advanced chronic heart failure patients. Aim: To describe the challenges and outline strategies of recruiting advanced chronic heart failure patients. Design: A feasibility study using a pre–post uncontrolled design. Setting: Advanced chronic heart failure patients were recruited at two nurse-led chronic heart failure disease management clinics in Ireland Results: Of 372 patients screened, 81 were approached, 38 were recruited (46.9% conversion to consent) and 25 completed the intervention. To identify the desired population, a modified version of the European Society of Cardiology definition was used together with modified New York Heart Association inclusion criteria to address inter-study site New York Heart Association classification subjectivity. These modifications substantially increased median monthly numbers of eligible patients approached (from 8 to 20) and median monthly numbers recruited (from 4 to 9). Analysis using a mortality risk calculator demonstrated that recruited patients had a median 1-year mortality risk of 22.7 and confirmed that the modified eligibility criteria successfully identified the population of interest. A statistically significant difference in New York Heart Association classification was found in recruited patients between study sites, but no statistically significant difference was found in selected clinical parameters between these patients. Conclusion: Clinically relevant modifications to the European Society of Cardiology definition and strategies to address New York Heart Association subjectivity may help to improve advanced chronic heart failure patient recruitment in clinical settings, thereby helping to address the paucity of palliative care research this population.
Experiencing place: Younger people with dementia facing aged care
Authors: Rimkeit Sally , McIntosh Jacqueline 
Published: May 2017

Objectives: There are currently few facilities for people with younger onset dementia and they are placed by default into dementia care facilities designed for the elderly. There is limited understanding of how people with younger onset dementia and their care givers anticipate or experience aged residential care. This qualitative study has used semi-structured interviews to give voice to the opinions and perspectives of nine people with younger onset dementia and 11 care givers. Method: Interpretative Phenomenological Analysis was used for idiographic analysis, allowing examination of the lived experience of younger people with dementia and an iterative exploration of what their experiences mean. Results: Themes of memory, autonomy and therapy emerged from the data. There is a need for a familiar memory of place in an intergenerational community and home-like setting. The loss of autonomy and ensuing stagnation or even institutional internment was much feared. Appropriate exercise and purposeful occupational activities as well as emotional support were valued therapies but often lacking for this group Conclusions: Emotional distress with the loss of a meaningful life can result from the placement of younger people with dementia into old age services. Development of age-appropriate services are required.
Role of motivation and attitude: Learning Turkish and Greek in Cyprus
Authors: Sallı Ayşegül 
Published: May 2017

Aims and Objectives/Purpose/Research Questions: After years of conflict, struggle and separation, the partial opening of the Green Line that divides Cyprus made mutual transitions and contact between the Turkish and Greek Cypriots possible. Soon after, Greek and Turkish language courses started to attract interest and gained popularity. This study aims to identify the motivations that led both community members to learn the language of ‘the other community’ and discover their attitudes towards each other and the target language. Design/Methodology/Approach: A questionnaire that includes motivation and attitude scales and subscales on a five-point Likert-type scale was prepared both in Turkish and English. It was distributed to the Turkish and Greek Cypriots who were attending evening classes at that time. The study employed a quantitative approach. Data and Analysis: Statistical analysis was performed with the SPSS 18 statistical package. Frequency analysis and independent samples t-tests were applied. Results/Conclusions: Both community members have intrinsic motivation to continue the language classes. The participants express their enjoyment of the feeling of accomplishment that comes with learning to speak another language successfully in this regard. The Greek Cypriots are driven by their integrative motivation as they illustrate their wish to feel closer to the Turkish Cypriots and communicate with them. In terms of language attitudes, the Turkish Cypriots tend to exhibit more positive attitudes, mostly due to economic reasons. However, the fact that the Greek Cypriots do not cross the border seems to reveal their negative attitudes towards the Turkish Cypriots. Overall, the members of both communities are hesitant to express their opinions about each other. Originality and Significance/Implications: This study provides the evidence that despite having a cautious stance towards the other community, various motivational factors encourage Turkish and Greek Cypriots to take language classes. The study emphasizes that more steps should be taken both at social and political levels to bring the members of the two Cypriot communities closer, to enable language contact, and to smooth out the sceptic attitudes about each other.
Structure to utilize interventionists’ implementation experiences of a family-based behavioral weight management program to enhance the dissemination of the standardized intervention: The TODAY study
Authors: Chadwick Jennifer Q , Van Buren Dorothy J , Morales Elisa , Timpson Alexandra , Abrams Ericka L , Syme Amy , Preske Jeff , Mireles Gerardo , Anderson Barbara , Grover Nisha , Laffel Lori 
Published: May 2017

Background For a 2- to 6-year period, interventionists for the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) randomized clinical trial delivered a family-based, behavioral weight-loss program (the TODAY Lifestyle Program) to 234 youth with type 2 diabetes. Interventionists held at least a bachelor’s degree in psychology, social work, education, or health-related field and had experience working with children and families, especially from diverse ethnic and socioeconomic backgrounds. This article describes the administrative and organizational structure of the lifestyle program and how the structure facilitated collaboration among study leadership and lifestyle interventionists on the tailoring of the program to best suit the needs of the trial’s diverse patient population. Methods During the pilot phase and throughout the duration of the trial, the interventionists’ experiences in delivering the intervention were collected in a variety of ways including membership on study committees, survey responses, session audio recordings, and feedback during in-person trainings. Results The experiences of interventionists conveyed to study leadership through these channels resulted in decisions to tailor the lifestyle intervention’s delivery location and ways to supplement the standardized educational materials to better address the needs of a diverse patient population. Conclusion The methods used within the TODAY study to encourage and utilize interventionists’ experiences while implementing the lifestyle program may be useful to the design of future multi-site, clinical trials seeking to tailor behavioral interventions in a standardized, and culturally and developmentally sensitive manner.
Accuracy of a CGM Sensor in Pediatric Subjects With Type 1 Diabetes. Comparison of Three Insertion Sites: Arm, Abdomen, and Gluteus
Authors: Faccioli Simone , Del Favero Simone , Visentin Roberto , Bonfanti Riccardo , Iafusco Dario , Rabbone Ivana , Marigliano Marco , Schiaffini Riccardo , Bruttomesso Daniela , Cobelli Claudio ,   on behalf of the PedArPan Study Group
Published: May 2017

Background: Patients with diabetes, especially pediatric ones, sometimes use continuous glucose monitoring (CGM) sensor in different positions from the approved ones. Here we compare the accuracy of Dexcom® G5 CGM sensor in three different sites: abdomen, gluteus (both approved) and arm (off-label). Method: Thirty youths, 5-9 years old, with type 1 diabetes (T1D) wore the sensor during a clinical trial where frequent self-monitoring of blood glucose (SMBG) measurements were obtained. Sensor was inserted in different sites according to the patient habit. Accuracy metrics include absolute relative difference (ARD) and absolute difference (AD) of CGM with respect to SMBG. The three sites were compared with ANOVA. If the test detected a difference, an additional pair-wise comparison was performed. Results: Overall, no accuracy difference was detected: the mean ARD was 13.3% (SD = 13.5%) for abdomen, 13.4% (12.9%) for arm and 12.9% (20.2%) for gluteus ( P value = .83); the mean AD was 17.0 mg/dl (17.2 mg/dl) for abdomen, 17.2 mg/dl (17.1 mg/dl) for arm and 18.3 mg/dl (18.5 mg/dl) for gluteus ( P value = .30). In hypo- and euglycemia ARD ( P value = .87 and .15, respectively), and AD ( P value = .68 and .37, respectively) were not statistically different. At variance, in hyperglycemia, a significant difference was detected between the two approved sites, abdomen and gluteus (ΔARD = −2.2% [CI = −4.2%, −0.1%], P value = .04), whereas the comparisons with the off-label location, arm-abdomen, and arm-gluteus were not significant. Conclusions: These results suggest that the accuracy of the sensor placed on the arm was not significantly different with respect to the two approved insertion sites (abdomen and gluteus). Larger, randomized trials are needed to draw final conclusions.
Benefits Achieved for Patients Through Application of Height-Adjustable Examination Tables
Authors: Fragala Guy , Labreche Manon , Wawzynieki Patti 
Published: May 2017

Objectives: Ambulatory care is a rapidly growing segment of overall healthcare delivery and populations seen in ambulatory care settings are aging resulting in many patients with mobility limitations. Mounting a fixed height examination table can present a challenge to a patient with mobility limitations and may be somewhat difficult for the general patient population. This study sought to investigate potential benefits to the patient which might be achieved through introduction of height adjustable examination tables. Methods: A data collection tool was administered to patients at the time of a regularly scheduled clinic visit intended to measure exertion required, level of difficulty and feeling of safety. Results: Both patients requiring assistance and independent patients reported higher exertion, more difficulty and feeling less safe when mounting higher fixed height versus height adjustable examination tables. Conclusions: Height adjustable examination tables provide benefits to patients and should be considered when seeking furnishings for ambulatory care clinics.
Hansesmarkite, Ca2Mn2Nb6O19·20H2O, a new hexaniobate from a syenite pegmatite in the Larvik Plutonic Complex, southern Norway
Authors: Friis H. , Weller M. T. , Kampf A. R. 
Published: May 2017

AbstractThe new mineral hansesmarkite (IMA2015-067), Ca2Mn2Nb6O19·20H2O, was discovered at the AS Granit larvikite quarry in Tvedalen, Larvik, Vestfold, Norway. Hansesmarkite forms faintly yellow crystals up to 0.3 mm or thin coatingsin patches on gonnardite. Hansesmarkite is biaxial (+) with refractive indices (white light): α = 1.683(2), β = 1.698(2) and γ = 1.745(3); 2V(meas.) = 60.7(6)° and 2V(calc.) = 60.3°. The mineral exhibits moderate dispersion (r>v)and is pleochroic withX(almost colourless) <Y( pale yellow) <<Z(orangey yellow). The optical orientation isX^c= 20°,Y^b= 16° andZ^a= 5°. The empirical formula based on five electron probemicroanalyses and calculated based on Nb = 6 apfu is (Ca1.93Na0.02K0.01)∑1.96(Mn1.79Fe0.11)∑1.90Nb6O18.84·20H2O, with H2O determined from the structure solution.The mineral is triclinic,P1, witha= 9.081(4),b= 9.982(8),c= 10.60(1) Å, α = 111.07(8), β = 101.15(6), γ = 99.39(5)°,V= 850.8(13) Å3 andZ= 1. The structure was solved at 120 K because of thermalinstability of the mineral and refined toR1= 2.50% forFo> 4σ. The strongest reflections in the x-ray diffraction diagram are: [dobs. in Å (I)(hkl)] 9.282(36)(001), 8.610(100)(100, 011), 3.257(30)(031, 131)and 3.058(18)(130, 212). Hansesmarkite is the third naturally occurring hexaniobate in which six edge-sharing Nb-octahedra form the Lindqvist ion. These are linked via Mn-octahedra forming rods along [100] and Ca is located between the rods, creating a three dimensional structure via hydrogen bonds.