bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological responses to short-term thermal stress in mayfly (Neocloeon triangulifer) larvae in relation to upper thermal limits
Authors: Kim Kyoung Sun , Chou Hsuan , Funk David H. , Jackson John K. , Sweeney Bernard W. , Buchwalter David B. 
Published: July 2017

ABSTRACT
Understanding species' thermal limits and their physiological determinants is critical in light of climate change and other human activities that warm freshwater ecosystems. Here, we ask whether oxygen limitation determines the chronic upper thermal limits in larvae of the mayfly Neocloeon triangulifer, an emerging model for ecological and physiological studies. Our experiments are based on a robust understanding of the upper acute (∼40°C) and chronic thermal limits of this species (&gt;28°C, ≤30°C) derived from full life cycle rearing experiments across temperatures. We tested two related predictions derived from the hypothesis that oxygen limitation sets the chronic upper thermal limits: (1) aerobic scope declines in mayfly larvae as they approach and exceed temperatures that are chronically lethal to larvae; and (2) genes indicative of hypoxia challenge are also responsive in larvae exposed to ecologically relevant thermal limits. Neither prediction held true. We estimated aerobic scope by subtracting measurements of standard oxygen consumption rates from measurements of maximum oxygen consumption rates, the latter of which was obtained by treating with the metabolic uncoupling agent carbonyl cyanide-4-(trifluoromethoxy) pheylhydrazone (FCCP). Aerobic scope was similar in larvae held below and above chronic thermal limits. Genes indicative of oxygen limitation (LDH, EGL-9) were only upregulated under hypoxia or during exposure to temperatures beyond the chronic (and more ecologically relevant) thermal limits of this species (LDH). Our results suggest that the chronic thermal limits of this species are likely not driven by oxygen limitation, but rather are determined by other factors, e.g. bioenergetics costs. We caution against the use of short-term thermal ramping approaches to estimate critical thermal limits (CTmax) in aquatic insects because those temperatures are typically higher than those that occur in nature.
The Effect of Anion-sublattice Structure on the Displacement Reaction in Copper Sulfide Cathodes of Rechargeable Magnesium Batteries
Authors: Tashiro Yuta , Taniguchi Kouji , Miyasaka Hitoshi 
Published: July 2017

Abstract
Copper sulfides (Cu2−xS, where x denotes position defects) with different structures of the S2− sublattice, such as cubic digenite and hexagonal chalcocite, have been investigated as cathode materials for magnesium (Mg) batteries. Rechargeable performance is only achieved using a cubic digenite cathode; however, using hexagonal chalcocite cathode yields poor rechargeable performance. The face-centered cubic S2− sublattice in cubic digenite, which enables Cu+ and Mg2+ ions to be displaced from each other without causing the lattice to collapse, could play a key role in improving the performance of rechargeable cathodes.
Risk Aversion and Son Preference: Experimental Evidence from Chinese Twin Parents
Authors: Hong Chew Soo , Yi Junjian , Zhang Junsen , Zhong Songfa 
Published: July 2017

We study the role of risk aversion underlying son preference in patriarchal societies, where sons serve as better insurance for old-age support than daughters. The implications of an insurance motive on son preference are twofold. First, prior to the birth of their children, more-risk-averse parents have a stronger preference for sons than for daughters. Second, after the birth of their children, parents with sons are more risk seeking, compared to parents with daughters. We adopt a within-twin-pair fixed-effects estimator with a weak identification assumption, which enables us to jointly identify these two effects. We further conduct an incentivized choice experiment to assess parental risk attitude in a sample of Chinese twins with children, and follow up with a second twin sample to examine the replicability of the findings. In both samples, we find that parents with higher risk aversion before the birth of their children are more likely to have sons through sex selection than parents with lower risk aversion. Additionally, having sons significantly decreases parental risk aversion. These results contribute to the literature on the sources of son preference and help shed light on the nature of gender inequality. Data are available at https://doi.org/10.1287/mnsc.2017.2779 . This paper was accepted by John List, behavioral economics.
Microgeography and the Direction of Inventive Activity
Authors: Catalini Christian 
Published: July 2017

I provide novel empirical evidence grounded in an original theoretical framework to explain why colocation matters for the rate, direction, and quality of scientific collaboration. To address endogeneity concerns due to selection into colocation and matching, I exploit the constraints imposed on the spatial allocation of labs on the Jussieu campus of Paris by the removal of asbestos from its buildings. Consistent with search costs constituting a major friction to collaboration, colocation increases the likelihood of joint research by 3.5 times, an effect that is mostly driven by lab pairs that face higher search costs ex ante. Furthermore, separation does not negatively affect collaboration between previously colocated labs. However, while colocated labs grow increasingly similar in topics and literature cited, separated ones embark on less correlated research trajectories. Research outcomes, instead, seem to be mostly influenced by how distance affects execution costs: after colocation, labs are more likely to pursue both lower-quality projects (a selection effect) and high-quality projects (an effort effect). Opposite effects on quality are observed after separation. Whereas search costs affect which scientists are likely to collaborate together, execution costs shape the quality of their output. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2798 . This paper was accepted by Ashish Arora, entrepreneurship and innovation.
Synthetic Circulating Cell-free DNA as Quality Control Materials for Somatic Mutation Detection in Liquid Biopsy for Cancer
Authors: Zhang Rui , Peng Rongxue , Li Ziyang , Gao Peng , Jia Shiyu , Yang Xin , Ding Jiansheng , Han Yanxi , Xie Jiehong , Li Jinming 
Published: July 2017

AbstractBACKGROUNDDetection of somatic genomic alterations in tumor-derived cell-free DNA (cfDNA) in the plasma is challenging owing to the low concentrations of cfDNA, variable detection methods, and complex workflows. Moreover, no proper quality control materials are available currently.METHODSWe developed a set of synthetic cfDNA quality control materials (SCQCMs) containing spike-in cfDNA on the basis of micrococcal nuclease digestion carrying somatic mutations as simulated cfDNA and matched genomic DNA as genetic background to emulate paired tumor-normal samples in real clinical tests. Site-directed mutagenesis DNA that contained 1500–2000 bases with single-nucleotide variants or indels and genomic DNA from CRISPR/Cas9 edited cells with EML4-ALK rearrangements was fragmented, quantified, and added into micrococcal nuclease-digested DNA derived from HEK293T cells. To prove their suitability, the SCQCMs were compared with patient-derived plasma samples and validated in a collaborative study that encompassed 11 laboratories.RESULTSThe results of SCQCM analysis by next-generation sequencing showed strong agreement with those of patient-derived plasma samples, including the size profile of cfDNA and the quality control metrics of the sequencing data. More than 95% of laboratories correctly detected the SCQCMs with EGFR T790M, L858R, KRAS G12D, and a deletion in exon 19, as well as with EML4-ALK variant 2.CONCLUSIONSThe SCQCMs were successfully applied in a broad range of settings, methodologies, and informatics techniques. We conclude that SCQCMs can be used as optimal quality controls in test performance assessments for circulating tumor DNA somatic mutation detection.
Modernidad y tipología
Authors: Collado Dra. Arq. Adriana 
Published: July 2017

Este trabajo surgió de un seminario de posgrado cursado en la FADU-UNL, donde se discutió si las composiciones de los trazados reguladores corbusieranos o la recurrencia a soluciones prototípicas en la vivienda en serie, constituían manipulaciones tipologistas, apareciendo el interrogante acerca de cómo estas operaciones se articulaban con las lógicas proyectuales propias de la modernidad. Esta idea detonó una indagación, que más tarde se profundizó a través de un seminario que la autora lleva adelante en la misma facultad desde 2004, respecto de la pertinencia de encuadrar a Le Corbusier como tipologista. El objetivo de este trabajo estuvo centrado en verificar la posibilidad y riqueza que puede presentar el concepto de tipo para analizar la obra de Le Corbusier, mostrando las alusiones explícitas o implícitas al concepto realizadas por la historiografía o la crítica e indagando en la producción teórica del propio Le Corbusier, la aproximación a este concepto.
Führt das autonome Fahrzeug zu mehr Sicherheit und Effizienz im
Straßenverkehr?
Authors: Zimmer Alf C. 
Published: July 2017

Zusammenfassung
Die Versprechen einer Vollautomatisierung des Individualverkehrs werden analysiert
und es wird gezeigt, dass ein derart komlexes System hochgradig fragil ist und daher
wahrscheinlich weder hinsichtlich Sicherheit noch hinsichtlich Effizient die Leistung
erbringen kann, die durch hybride Mensch-Maschine-Systeme erreicht werden können.
Es wird insbesondere auf die Übernahme-Problematik z. B. von Autopilot auf manuelle
Steuerung verwiesen. Als konzeptueller Ansatz für ein solches System kann die der Feld-theoretische Ansatz
von Gibson & Crooks genommen werden.
Von der Rennstrecke auf die Straße
Authors: Siedersberger Karl-Heinz 
Published: July 2017

Zusammenfassung
Innovationen entstehen oftmals auf der Rennstrecke. Damit daraus kundenwerte Produkte werden, bedarf es weiterer
Entwicklungsmaßnahmen und Tests. Dies betrifft im besonderen Maße Fahrerassistenzsysteme, die per se einer
intensiven Interaktion zwischen Fahrer und System unterliegen. Anhand eines für die Rennstrecke entwickelten
Fahrdynamikreglers für das fahrerlose Fahren wird gezeigt, wie dieser unter Nutzung von Ergebnissen zur Auslegung der
Mensch-Maschine-Schnittstelle für das automatische Ausweichen adaptiert wurde.
Parent reported nutritional risk and laboratory indices of cardiometabolic risk and in preschool-aged children
Authors: Persaud Navindra , Ziai Hedyeh , Lebovic Gerald , Maguire Jonathon L. , Khovratovich Marina , Simpson Janis A. Randall , Adeli Khosrow , Hamilton Jill , McCrindle Brian W. , Parkin Patricia C. , Birken Catherine S. 
Published: July 2017

AbstractBackground:Eating habits formed during childhood may contribute to the increasing prevalence of cardiometabolic disorders. Assessing nutritional risk in young children may help to prevent later cardiometabolic disease. The objective of this study was to determine whether parent-reported nutritional risk in preschool-aged children was associated with laboratory indices of cardiometabolic risk, namely leptin and insulin.Methods:In this cross-sectional study, the relationship between nutritional risk as determined by the parent-completed NutriSTEPResults:The total NutriSTEPConclusions:Parent reported nutritional risk is associated with serum leptin, but not insulin, concentrations in preschool-aged children. The NutriSTEP
Electrochemotherapy – supplementary treatment for loco-regional metastasized breast carcinoma administered to concomitant systemic therapy
Authors: Grischke Eva-Maria , Röhm Carmen , Stauß Eva , Taran Florin-Andrei , Brucker Sara Y. , Wallwiener Diethelm 
Published: July 2017

Abstract

Background
Electrochemotherapy (ECT) is an established procedure for treating breast cancer loco-regional recurrences following surgical intervention and/or radiotherapy. Limited information is available on ECT application as a concomitant procedure to systemic therapy in recurrent breast cancer. The primary objective of this study was to determine if the application of ECT in close temporal relation to systemic chemotherapy could lead to increased local and/or systemic side effects. For this purpose we evaluated the safety of ECT as a supplemental local therapy to systemic therapy. ECT local and systemic toxicity and side effects were recorded and whether the anticipated local therapeutic effect of ECT would be influenced by the concomitant use of systemic therapies was investigated.

Patients and methods
This is an observational study. Thirty three patients with loco-regional metastasized breast carcinoma were treated and observed over a period of three years with 46 ECT applications for local tumour control in addition to established systemic therapy. A specific timeline for ECT administration was not fixed up, but was generally performed one week before the following chemotherapy administration with the aim to avoid the so called nadir, this means the peak period with risk of neutropenia.

Results
Data was collected over a period of three years on a population of 33 metastatic patients. Fifteen patients, received neo-adjuvant therapy as part of their primary treatment, but still had an advanced stage tumour. Some patients received repeated ECT applications. Objective tumour response was observed in 90% of the treated patients. Patients showed no increased local toxicity, especially no higher dermal toxicity, e.g. formation of local necrosis.

Conclusions
ECT proved to be an effective supplement to a cytotoxic systemic therapy, especially for high-risk patients who did not respond well to systemic therapy of loco-regional metastases, without creating any greater systemic or loco-regional toxicities.
Selection of non-small cell lung cancer patients for intercalated chemotherapy and tyrosine kinase inhibitors
Authors: Zwitter Matjaz , Rossi Antonio , Di Maio Massimo , Perme Maja Pohar , Lopes Gilberto 
Published: July 2017

Abstract

Background
When treating patients with advanced non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors and chemotherapy, intercalated schedule with time separation between the two classes of drugs should avoid their mutual antagonism. In a survey of published trials, we focus on relation between eligibility criteria and effectiveness of intercalated treatment.

Methods
Published documents were identified using major medical databases, conference proceedings and references of published trials. Median progression-free survival (PFS) was taken as the basic parameter of treatment efficacy. Correlation between characteristics of patients and median PFS was assessed through the Pearson’s correlation coefficient and the coefficient of determination, separately for first-line and second-line setting.

Results
The series includes 11 single-arm trials and 18 randomized phase II or phase III trials with a total of 2903 patients. Treatment-naive patients or those in progression after first-line treatment were included in 16 and 13 trials, respectively. In 14 trials, only patients with non-squamous histology were eligible. Proportion of patients with non-squamous carcinoma (in first-line setting), proportion of never-smokers (both in first- and second-line setting) and proportion of epidermal growth factor receptor (EGFR) mutant patients (both in first- and second-line setting) showed a moderate or strong correlation with median PFS. In six trials of intercalated treatment applied to treatment-naive EGFR-mutant patients, objective response was confirmed in 83.1% of cases and median PFS was 18.6 months.

Conclusions
Most suitable candidates for intercalated treatment are treatment-naive patients with EGFR-mutant tumors, as determined from biopsy or liquid biopsy. For these patients, experience with intercalated treatment is most promising and randomized trials with comparison to the best standard treatment are warranted.
The German Occupation Regimes in Southeastern Europe as a Research Problem in Yugoslav and Serbian Historiography
Authors: Ristović Milan 
Published: July 2017

Abstract
The author revisits works produced during the time of socialist Yugoslavia to assess the historiographical literature on the German occupation regimes there. He concludes that since Yugoslavia’s demise there has been hardly any evolution towards a more solid nor more differentiated historiography such as would meet international standards. To be sure, significant new research has been produced, but it has been hampered by the narrow and often difficult academic frameworks that have existed in the last twenty-five years. Scholars have been expected to respond to the new nationalized agendas of the successor states, and have seen few structural incentives to link their work to international research networks, or to the work of their colleagues in neighbouring countries. The author’s focus is the German occupation of Serbia, but he includes some examples of scholars whose focus is German-occupied Slovenia, or the Independent State of Croatia, and he keeps in perspective the wider (Southeast) European contexts.
Holocaust Research in Croatia, Bosnia and Herzegovina, and Serbia. An Inventory
Authors: Vulesica Marija 
Published: July 2017

Abstract
The Holocaust and other mass killings committed during the Second World War in the Yugoslav territories play a more significant role in current public debates than they do in education and research. 85% of Yugoslavia’s Jews were annihilated in the period between 1941 and 1945. In socialist Yugoslavia, it was Holocaust survivors in particular who collected materials that documented the execution of exterminist policies. How has the examination of the Holocaust changed since the dissolution of Yugoslavia; and how have the newly established states of Croatia, Bosnia and Herzegovina, as well as Serbia coped with this part of their history? The author asks whether an exclusive exploration of Jewish suffering is possible—or even desirable—in today’s post-Yugoslav societies. She gives an overview of the evolution of a specific ‘Yugoslav’ approach to the history of the Holocaust, and depicts recent Croatian, Bosnian, and Serbian efforts in this field. Furthermore, she looks at what kind of attention the Holocaust in Yugoslavia has received in international Holocaust Studies.
Investigation of the effect of cornelian cherry (Cornus mas L.) fruit extract against cisplatin-induced renal cell injury in vitro
Authors: Yarim Gul Fatma , Kazak Filiz , Sozmen Mahmut , Koca Ilkay , Albayrak Harun , Yarim Murat , Cenesiz Sena , Ozan Emre 
Published: July 2017

Abstract

Objective
The aim of this study was to evaluate the protective effects of cornelian cherry fruit extract against cisplatin-induced nephrotoxicity in vitro.

Materials and methods
African green monkey kidney epithelial cells (Vero) were incubated with 100 mg/mL of cornelian cherry fruit extract, 50 μmol/L of cisplatin or 50 μmol/L of cisplatin plus 100 mg/mL of cornelian cherry fruit extract for 4 h. The wells containing cells without any supplementation served as control. Cell viability was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliumbromide assay. Culture mediums were collected, centrifuged and analyzed for malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx).

Results
The cell viability was 59% in cells co-treated with cisplatin and cornelian cherry fruit extract simultaneously and 42% in cisplatin treated cells. The cellular damage ratio was elevated in cells treated with cisplatin. However, when cisplatin combined with cornelian cherry fruit extract the deleterious effects of cisplatin were significantly decreased. The MDA concentration was significantly higher (p<0.05), GSH concentration and GPx and SOD activities were significantly lower (p<0.05) in cisplatin treated group when compared with control group, cornelian cherry group, and cisplatin+cornelian cherry group.

Conclusion
The present study indicated that cornelian cherry fruit extract exert protective effects on oxidative damage in vitro induced by cisplatin.
Syntheses of benzo[c]coumarin carboxylic acids and fluorescence properties in the solid state
Authors: Shi Juan , Liang Yong , Zhang ZunTing 
Published: July 2017

Abstract
7-Hydroxy-3-methoxy-6-oxo-6H-benzo[c]- chromene-8-carboxylic acid (3a), 3,7-dihydroxy-6-oxo-6H- benzo[c]chromene-8-carboxylic acid (3b), 1,7-dihydroxy-6-oxo-6H-benzo[c]chromene-8-carboxylic acid (3c) and 2-bromo-7-hydroxy-6-oxo-6H-benzo[c]chromene-8-carboxylic acid (3d) were synthesized and characterized by the method of single crystal X-ray diffraction. Owing to bigger conjugated system and various H-bonds in 7-hydroxy-6-oxo-6H-benzo[c]chromene-8-carboxylic skeleton, 3a–3c have excellent fluorescence in ethanol solution and the solid state. The synthons involved in each crystal are identified, and the fluorescence emission differences leading to molecular recognition are determined.
Structural investigation and Hirshfeld surface analysis of three organic picrate salts
Authors: Loh Wan-Sin , Kwong Huey Chong , Kumar C.S. Chidan , Quah Ching Kheng 
Published: July 2017

Abstract
Three picrate salt crystals, namely 5-amino-6-methylquinolin-1-ium 2,4,6-trinitrophenolate (I), 3-phenyl-1H-pyrazol-2-ium 2,4,6-trinitrophenolate (II) and 1H-imidazol-3-ium 2,4,6-trinitrophenolate (III) were characterized by X-ray diffraction. Salt I crystallizes in space group of P21/c, with a=15.096(2), b=7.2864(9), c=15.248(2) Å, β=98.437(2)°, V=1659.1 Å3 and Z=4. Salt II crystallizes in monoclinic space group P21/c, with a=13.6230(9), b=6.7421(5), c=17.7508(12) Å, β=106.001(1)°, V=1567.20 Å3 and Z=4. Whereas salt III crystallizes in triclinic system, space group P1̅, with a=7.6919(10), b=7.9218(10), c=10.2230(13) Å, α=81.909(2), β=77.985(2), γ=82.629(2)°, V=600.05 Å3 and Z=2. Protons were transferred from the picric acids to their corresponding bases, forming intermolecular N+–H···O− hydrogen bonds in the three salts. Salts I and II form planes, whereas salt III forms chains via N–H···O and C–H···O hydrogen bonds as their supramolecular assembly. Planes and chains in all these salts were interconnected through π···π interaction. The intermolecular interactions in the crystal structures were quantified and were analysed using Hirshfeld surface analysis.
Vector Dark Solitons for a Coupled Nonlinear Schrödinger System with Variable Coefficients in an Inhomogeneous Optical Fibre
Authors: Liu Lei , Tian Bo , Wu Xiao-Yu , Yuan Yu-Qiang 
Published: July 2017

AbstractStudied in this paper are the vector dark solitons for a coupled nonlinear Schrödinger system with variable coefficients, which can be used to describe the pulse simultaneous propagation of theM-field components in an inhomogeneous optical fibre, whereMis a positive integer. WhenM=2, under the integrable constraint, we construct the nondegenerateN-dark-dark soliton solutions in terms of the Gramian through the Kadomtsev–Petviashvili hierarchy reduction. With the help of analytic analysis, a vector one soliton with varying amplitude and velocity is studied. Interactions and bound states between the two solitons under different group velocity dispersion and amplification/absorption coefficients are presented. Moreover, we extend our analysis to anyMto obtain the nondegenerate vectorN-dark soliton solutions.