bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polite, professional, practical: What drives caller ‘satisfaction’ with the New South Wales Quitline, Australia
Authors: Grunseit Anne Carolyn , Gwizd Melissa , Lyons Claudine , Anderson Caroline , O'Hara Blythe Jane 
Published: August 2017

AbstractIntroduction and AimsPrevious studies on smoking quitlines have focused on service effectiveness and usage, describing client characteristics, referral sources and service utilisation. There is a lack of qualitative research examining callers’ perspectives on service quality. The analysis aimed to describe the factors which underpin quitline callers’ descriptions of their satisfaction with the service.Design and MethodsWe conducted qualitative interviews with 46 callers to the NSW Quitline's English and multilingual lines. We used an iterative, inductive, thematic approach to identify common patterns within interviewees’ descriptions of what informed their level of satisfaction with the service.ResultsInterviewees evaluated the Quitline service format (frequency, duration and convenience of call‐backs), call content and advisor competence in terms of whether these components conveyed care, developed rapport and demonstrated a general professionalism (polite, reliable and convenient service). Satisfaction rested on callers finding advice and resources personally relevant and matching prior expectations, although many did not have an accurate idea of Quitline's services prior to calling. These themes were evident across age, gender, language background and quitting status.Discussion and Conclusions‘Satisfaction’ with Quitline is complex and not wholly dependent on achieving cessation. Evaluations emerged out of dynamic interactions between callers’ preconceived notions and needs of smoking cessation services and the particular service experience of the caller. While callers’ descriptions of the Quitline were predominantly positive, developing specialised modules for long‐term smokers and those with a strong sense of personal responsibility for quitting may broaden the utility of the service.
Analysing plant–pollinator interactions with spatial movement networks
Authors: PASQUARETTA CRISTIAN , JEANSON RAPHAËL , ANDALO CHRISTOPHE , CHITTKA LARS , LIHOREAU MATHIEU 
Published: August 2017

1. Pollinators, such as bees, face the complex challenge of efficiently exploiting patchily distributed floral resources across large landscapes.2. In the present study we consider the utility of spatial network statistics to analyse the foraging patterns of bees moving between feeding sites at various spatial and temporal scales.3. We explain how spatial movement networks can be derived theoretically and experimentally to describe bee foraging decisions.4. We illustrate this approach by analysing six datasets of bumblebees and honeybees foraging in arrays of artificial flowers, and showing how network metrics change as foragers gain experience with the spatial distribution of feeding sites.5. We compare network analyses with more conventional statistics used to characterise bee foraging movements and discuss the implications of our novel statistical and modelling approach for pollination ecology.
Decision‐making and motor control in predatory insects: a review of the praying mantis
Authors: YAMAWAKI YOSHIFUMI 
Published: August 2017

Abstract1. Predatory and defensive behaviours require multiple stages of decision‐making in predatory insects, such as the praying mantis.2. During predation, a praying mantis must decide where to ambush prey and which prey to fixate on, catch, and eat. The mantis also needs to decide how to track, approach, and catch prey, all the while controlling these actions depending on the visual features and position of the prey. For defence, a mantis must decide when to be defensive and which defensive response to initiate.3. This review summarises the current knowledge of decision‐making processes and the corresponding motor control in the mantis, remarking on the importance of considering the interaction between predatory and defensive systems. Current research suggests that the mantis is a good model for revealing the mechanisms behind an animal's selection of a certain behaviour from a broad repertoire.
Cost‐effectiveness of early intervention services for psychosis and fidelity to national policy implementation guidance
Authors: Radhakrishnan Muralikrishnan , McCrone Paul , Lafortune Louise , Everard Linda , Fowler David , Amos Tim , Freemantle Nick , Singh Swaran P. , Marshall Max , Sharma Vimal , Lavis Anna , Jones Peter B. , Birchwood Max 
Published: August 2017

AimEarly intervention services (EIS) for psychosis are being implemented, internationally. It is important to learn from established examples and define the components and intensity of services that provide good value for money. This study aims to assess the cost‐effectiveness of EIS according to how closely they adhered to the recommendations of the English Department of Health 2001 Policy Implementation Guide (PIG).MethodsEIS from the National Eden Study were assessed using a measure of fidelity to the PIG that rated the presence or absence of 64 recommended items relating to team structure and practice. EIS were then classified into three groups: those with fidelity of 75–80%, 81–90% and 91–95%. Patient‐level resource use and outcomes were measured 1 year following inception into the service; costs were calculated and combined with quality‐adjusted life years (QALYs) gained.ResultsAt a threshold of £20 000 per QALY, the 81–90% fidelity group had a 56.3% likelihood of being the most cost‐effective option followed by 75–80% fidelity at 35.8% and 91–95% fidelity group (7.9%).ConclusionsThe results from England suggest that striving to maximize fidelity may not be warranted, but that dropping below a certain level of fidelity may result in inefficient use of resources.
Effects of pair bonding on parental behavior and dopamine activity in the nucleus accumbens in male prairie voles
Authors: Lei K. , Liu Y. , Smith A. S. , Lonstein J. S. , Wang Z. 
Published: August 2017

AbstractMale parental care is a vital behavior for the development as well as the physical and mental well‐being of the young. However, little is known about the neurochemical regulation of male parental behavior, mainly due to the lack of appropriate animal models. In this study, we used the socially monogamous male prairie vole (Microtus ochrogaster) to investigate the effect of pair‐bonding experience on paternal behavior and dopamine (DA) signaling in the nucleus accumbens (NAcc) in the brain. We compared sexually naïve males with males that were pair bonded with a female for two weeks. Our data showed that pair‐bonded males displayed enhanced paternal behavior, particularly in pup licking/grooming, associated with increased DA type‐1 receptor (D1R) protein expression in the NAcc, compared to sexually naïve males. Site‐specific brain microdialysis revealed a significant, but transient, increase in DA release in the NAcc associated with pup exposure in both groups of the males. Further, pharmacological blockade of D1R in the NAcc decreased pup licking/grooming in the pair‐bonded males. Together, our data demonstrate that pair‐bonding experience with a female facilitated male parental behavior via NAcc D1R mediation in male prairie voles.
Chemogenetic activation of the lateral hypothalamus reverses early life stress‐induced deficits in motivational drive
Authors: Campbell Erin J. , Mitchell Caitlin S. , Adams Cameron D. , Yeoh Jiann Wei , Hodgson Deborah M. , Graham Brett A. , Dayas Christopher V. 
Published: August 2017

AbstractAltered motivated behaviour is a cardinal feature of several neuropsychiatric conditions including mood disorders. One well‐characterized antecedent to the development of mood disorders is exposure to early life stress (ELS). A key brain substrate controlling motivated behaviour is the lateral hypothalamus (LH). Here, we examined the effect of ELS on LH activation and the motivation to self‐administer sucrose. We tested whether chemogenetic activation of LH circuits could modify sucrose responding in ELS rats and examined the impact on LH cell populations. Male rat pups were maternally separated for 0 or 3 h on postnatal days 2–14. During adolescence, rats received bilateral injections of hM3D(Gq), the excitatory designer receptor exclusively activated by designer drugs, into LH. In adulthood, rats were trained to self‐administer sucrose and tested under a progressive ratio schedule to determine their motivation for reward following injection with either vehicle or 5 mg/kg clozapine‐N‐oxide. Brains were processed for Fos‐protein immunohistochemistry. ELS significantly suppressed lever responding for sucrose, indicating a long‐lasting impact of ELS on motivation circuits. hM3D(Gq) activation of LH increased responding, normalizing deficits in ELS rats, and increased Fos‐positive orexin and MCH cell numbers within LH. Our findings indicate that despite being susceptible to environmental stressors, LH circuits retain the capacity to overcome ELS‐induced deficits in motivated behaviour.
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
Authors: Androsova Ganna , Krause Roland , Borghei Mojgansadat , Wassenaar Merel , Auce Pauls , Avbersek Andreja , Becker Felicitas , Berghuis Bianca , Campbell Ellen , Coppola Antonietta , Francis Ben , Wolking Stefan , Cavalleri Gianpiero L. , Craig John , Delanty Norman , Koeleman Bobby P. C. , Kunz Wolfram S. , Lerche Holger , Marson Anthony G. , Sander Josemir W. , Sills Graeme J. , Striano Pasquale , Zara Federico , Sisodiya Sanjay M. , Depondt Chantal ,   the EpiPGX Consortium
Published: August 2017

SummaryObjectiveMesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. We report retention, efficacy, and tolerability in a cohort of patients with MTLE‐HS.MethodsClinical data were collected from a European database of patients with epilepsy. We estimated retention, 12‐month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE‐HS.ResultsSeven hundred sixty‐seven patients with a total of 3,249 AED trials were included. The highest 12‐month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve‐month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia.SignificanceOur results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE‐HS.
The use of multimodal analgesia in the management of suspected extremity compartment syndrome in the pelvic limb of a horse
Authors: Bruniges N. , Milner P. , Bardell D. 
Published: August 2017

SummaryA 12‐year‐old Thoroughbred cross Dartmoor mare was referred to the clinic with marked lameness and swelling involving the left stifle region. There was poor initial response to medical management and arthroscopic examination of the stifle joint was performed under general anaesthesia. Following surgery, the lameness and swelling worsened and extremity compartment syndrome was suspected. A multimodal analgesia protocol was instigated to provide adequate analgesia and improved mobility, aiding the use of physical therapy in resolving the swelling. This report demonstrates the successful combination of nonsteroidal anti‐inflammatories, paracetamol, ketamine infusion and epidural opioid administration to manage the clinical signs. The mare was discharged from hospital after 15 days and at short‐term follow‐up (3 months), there was no reported residual swelling or lameness.
Crystal structure of a lipase from Streptomyces sp. strain W007 – implications for thermostability and regiospecificity
Authors: Zhao Zexin , Hou Shulin , Lan Dongming , Wang Xiumei , Liu Jinsong , Khan Faez Iqbal , Wang Yonghua 
Published: August 2017

MAS1 from marine Streptomyces sp. strain W007 belongs to the bacterial lipase I.7 subfamily and is characterized as a thermostable and nonregiospecific lipase. To shed light on the catalytic mechanism of MAS1, we determined its crystal structure with closed conformation in two crystal forms at 2.3 Å resolution. MAS1 adopts the canonical α/β hydrolase core fold with its catalytic triad being formed by S109, D200 and H232. Structural analysis and biochemical assays revealed that disulfide bonds and salt bridges play a vital role in the thermostability of MAS1. In addition, we discovered that the replacement of H108 with a tryptophan converts MAS1 from a nonregiospecific to an sn‐1,3‐specific lipase, suggesting the functional importance of the second position from the conserved pentapeptide motif in defining the regiospecificity of MAS1. Our present study provides insights into the molecular basis for the thermostability and regiospecificity of MAS1, and it may aid in the rational design of thermostable or regiospecific lipases for potential industrial applications.DatabaseStructural data are available in the Protein Data Bank database under the accession numbers 5H6B and 5H6G.
Subjective and objective halitosis among patients with Parkinson's disease
Authors: Barbe Anna Greta , Deutscher Deborah H. C. , Derman Sonja H. M. , Hellmich Martin , Noack Michael J. 
Published: August 2017

ObjectivesParkinson's disease (PD) affects oral health, but prevalence of subjective and objective halitosis and the influence of hyposalivation remain unclear. We aimed to explore whether patients with PD suffer from halitosis and to define correlations between halitosis and hyposalivation. We hypothesised that patients with PD suffer more often from halitosis compared to healthy controls, influenced by dry mouth.Materials and methodsSubjective (halitosis, xerostomia visual analogue scale [VAS], short German Oral Health Impact Profile [OHIPG]‐14) and objective scales (e.g., organoleptic score, volatile sulphur compounds [VSCs], stimulated whole saliva [SWS]) were assessed from 26 patients with PD and 26 healthy controls.ResultsThe mean organoleptic score was 0.7 (SD: 0.7) in all patients, and VSCs were either comparable or significantly lower (dimethyl sulphide, P = .010) in PD patients compared with controls, yet more patients with PD perceived halitosis to be stronger (77% vs 54%, respectively; P = .059). Dry mouth was significantly more likely in patients with PD than controls: mean xerostomia VAS 4 (SD: 2) vs 1 (SD: 2), P = .010; SWS 0.4 (SD: 0.4) vs 0.7 (SD: 0.6) mL/min, P < .05); SWS did not correlate with subjective or objective halitosis. Oral health‐related quality of life (OHRQoL) was lower in patients with PD than controls (mean OHIPG‐14 score 12 (SD: 0.2) vs 5 (SD: 7.0), respectively; P < .05).ConclusionsPatients with PD suffer from subjective and objective halitosis, dry mouth and impaired OHRQoL. Dry mouth problems do not correlate with prevalence or intensity of halitosis.
Trend of cardiovascular risk factors in the older Iranian population: 2002–2014
Authors: Eslami Ali , Lotfaliany Mojtaba , Akbarpour Samaneh , Azizi Fereidoun , Hadaegh Farzad 
Published: August 2017

AimCurrent study aimed to investigate the sex‐stratified secular trend of cardiovascular disease risk factors among an older population in Iran during a median follow‐up period of 8.76 years.MethodsA total of 1490 participants (733 women) aged ≥60 years were evaluated in four study phases of 2002–2005, 2005–2008, 2008–2011 and 2011–2014. The trends of cardiovascular disease risk factors for each sex were estimated using generalized estimating equations.ResultsThe age‐adjusted prevalence of diabetes, hypertension, central obesity, and chronic kidney disease at the baseline was 24%, 43%, 55%, and 32% in men and 31%, 57%, 60% and 53% in women, respectively, and had noticeable upward trend during the study period to reach 35%, 56%, 61% and 51% in men, and 42%, 71%, 74% and 67% in women, respectively. However, lipid profile parameters showed favorable trends. Despite the increasing trend in drug consumption, approximately 27% of women with diabetes and 37% of men with diabetes did not use antidiabetic medication, respectively; the results were 23% and 35% for hypertensive women and men, respectively. Among men, there was a decreasing trend towards low physical activity, from 40% at baseline to 26% at the most recent follow up. The prevalence of smoking remained steady throughout follow up.ConclusionsDespite the benefits of lipid lowering, the status of other risk factor profiles are often suboptimal in both sexes. There remains much room for improvement in risk factors management, particularly for hypertension, smoking and adiposity status, and a need for an intervention. Geriatr Gerontol Int 2018; 18: 130–137.
Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study
Authors: Xu Chunsheng , Tian Xiaocao , Sun Jianping , Wu Yili , Zhang Dongfeng , Pang Zengchang , Li Shuxia , Petersen Inge , Mengel‐From Jonas , Christiansen Lene , Christensen Kaare , Tan Qihua 
Published: August 2017

AbstractAimTo explore the genetic and environmental influences on cardiovascular risk factors (CVRF) and cognitive function in the world's largest and rapidly aging Chinese population.MethodsCognitive function and CVRF, including body mass index, systolic blood pressure, diastolic blood pressure, pulse pressure, glucose, total cholesterol, triglyceride, high‐density lipoprotein cholesterol (HDLC) and low‐density lipoprotein cholesterol were measured in 379 complete twin pairs. Univariate and bivariate twin models were fitted to estimate the genetic and environmental components in the variance and covariance of CVRF and cognition.ResultsMild‐to‐high heritability was estimated for CVRF and cognition (0.27–0.74). Unique environmental factors showed low‐to‐moderate contributions (0.23–0.56). Only HDLC presented significant common environmental contribution (0.50). Bivariate analysis showed significantly negative genetic correlations (rG) between cognition and systolic blood pressure (rG = −0.56), diastolic blood pressure (rG = −0.42), pulse pressure (rG = −0.45), and positive genetic correlations between cognition and total cholesterol (rG = 0.33), triglyceride (rG = 0.23) and HDLC (rG = 0.41). HDLC and cognition presented a unique environmental correlation (rE = −0.13), but in the opposite direction.ConclusionsCognitive function was genetically related to systolic blood pressure, diastolic blood pressure, pulse pressure, total cholesterol, triglyceride and HDLC with a negative or positive direction. Cognition and HDLC might share part of a similar unique environmental factor. Geriatr Gerontol Int 2018; 18: 352–359.
Psychometric Evaluation of a Novel Instrument Assessing the Impact of Migraine on Physical Functioning: The Migraine Physical Function Impact Diary
Authors: Kawata Ariane K. , Hsieh Ray , Bender Randall , Shaffer Shannon , Revicki Dennis A. , Bayliss Martha , Buse Dawn C. , Desai Pooja , Sapra Sandhya , Ortmeier Brian , Hareendran Asha 
Published: August 2017

ObjectiveThe objective of this study was to evaluate the measurement properties of the Migraine Physical Function Impact Diary (MPFID), a novel patient‐reported outcome (PRO) measure for assessing the impact of migraine on physical functioning.MethodsIn a prospective, observational study, adults with episodic migraine (EM) or chronic migraine (CM) used an eDiary to complete the MPFID (assessing daily impacts of migraine on physical function) and a headache diary (capturing migraine days, migraine pain intensity, and migraine interference) each day, and other PRO instruments related to migraine. Item‐level evaluation, item response theory (IRT), and exploratory factor analysis (EFA) methods were applied to identify domains, select final MPFID items, and develop scoring procedures. Psychometric properties of the final 13‐item MPFID were evaluated using confirmatory factor analysis and tests of reliability (Cronbach'sαfor internal consistency and intra‐class correlation [ICC] for test–retest) and validity (convergent and known‐groups).ResultsThe study enrolled 569 adults with chronic or episodic migraine, mean (SD) age 39.9 (12.0) years and 87.2% female. Item‐level analyses based on interim data informed selection of a set of 13 items for the MPFID, through evaluation of floor/ceiling effects, item‐to‐item correlations, factor loadings, and IRT‐based fit/misfit statistics. Two domain scores (EA: Impact on Everyday Activities; PI: Physical Impairment) and a global item score for impact on everyday activities were identified. EA and PI domains exhibited high internal consistency (α = 0.97;α = 0.93) and good test–retest reliability among stable subjects (ICCs = 0.74 and 0.77). Convergent validity was demonstrated by moderate correlations (r = ±0.50‐0.68;P < .0001) between MPFID domain scores and number of migraine days, headache days, bed days, and other migraine‐related PRO instruments. EA and PI scores differentiated between groups who varied by number of migraine days, migraine interference levels, migraine pain intensity, and median split groups of scores based on other PROs instruments (P < .05).ConclusionsThe MPFID has robust psychometric properties (ie, reliability and validity). Findings supported two distinct domains about the impact of migraine on physical functioning: Impact on Everyday Activities and Physical Impairment. Both domain scores showed evidence of excellent reliability and construct validity in assessing the impacts of migraine on physical functioning.