bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allopurinol as add-on treatment for mania symptoms in bipolar disorder: Systematic review and meta-analysis of randomised controlled trials
Authors: Bartoli Francesco , Crocamo Cristina , Clerici Massimo , Carrà Giuseppe 
Published: November 2016

BackgroundSince bipolar disorder seems to be associated with purinergic system dysfunction, allopurinol might be effective in treating symptoms of mania.AimsTo estimate the efficacy and tolerability of allopurinol as adjunctive treatment for mania symptoms in people with bipolar affective disorder.MethodWe conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing the effects of adjunctive allopurinol and placebo on mania symptom changes.ResultsFive RCTs were included in the meta-analysis. Participants with allopurinol augmentation had a significantly greater decrease in mania symptoms than those with placebo (SMD= −0.34, P = 0.007), especially in people with the most severe forms of mania. Remission rates, although based on only two studies (n = 177), were significantly higher among individuals receiving allopurinol, whereas for discontinuation and side-effects no difference was found.ConclusionsOur finding of a small to moderate effect size and overall low evidence for add-on allopurinol in reducing mania symptoms indicate that its use in routine practice needs further elucidation.
The Association Between Cyanosis and Thromboelastometry (ROTEM) in Children With Congenital Heart Defects: A Retrospective Cohort Study
Authors: Laskine-Holland Marie-Laure , Kahr Walter H. A. , Crawford-Lean Lynn , Humpl Tilman , Honjo Osami , Foreman Celeste , Jain Mehr , O’Leary James D. 
Published: November 2016

BACKGROUND:
Children with congenital heart defects (CHD) have quantitative and qualitative differences in coagulation compared with healthy children. Secondary to polycythemia and increased deformability of red blood cells, cyanosis may be an important confounding factor for altered whole-blood coagulation in this population with potential implications for interpreting intraoperative thromboelastometry (TEM) for children with CHD undergoing major surgery. The primary aim of the study was to evaluate the association between cyanosis in children with CHD and measures of whole-blood coagulation determined using TEM (ROTEM [Tem International, GmbH, Munich, Germany]).

METHODS:
In this retrospective cohort study, children who underwent congenital cardiac surgery in a 12-month period between April 2014 and 2015 were investigated. Children who were receiving antiplatelet or anticoagulant medications in the preoperative period were excluded. Eligible children were categorized by the presence of cyanosis, defined as an oxyhemoglobin concentration ≤85%. Multivariable linear regression analyses were used to determine the relationship between cyanosis and TEM outcomes (primary outcome, fibrinogen/fibrin polymerization [FibTEM] maximal clot firmness [MCF]) adjusting for potential confounding factors.

RESULTS:
Three hundred forty-five TEM profiles from 320 children were included in the cohort for analysis. Twenty-two percent (76/345) of children had cyanotic CHD. Clot firmness measured using the FibTEM assay was decreased in cyanotic children compared with noncyanotic children, median difference (95% confidence interval) interim [2 (0–3) mm; P = .01], and maximal [2 (1–3) mm; P = .01] clot firmness. The association between cyanosis and fibrinogen/fibrin polymerization clot firmness was not significant (A10, P = .7; MCF, P = .7) after adjusting for confounding factors (hematocrit, platelet count, and sex). There was a significant association between cyanosis and intrinsically activated clot firmness (A10, P = .03; MCF, P = .02), but not other TEM outcomes, after adjusting for confounding factors.

CONCLUSIONS:
Cyanotic children had decreased clot firmness in the fibrinogen/fibrin polymerization component of the clot compared with noncyanotic children, but the association between cyanosis and clot firmness was accounted for by differences in hematocrit, platelet count, and sex between groups. These findings will help guide the identification and treatment of coagulopathy in this vulnerable population.
Perforating the nuclear boundary – how nuclear pore complexes assemble
Authors: Weberruss Marion , Antonin Wolfram 
Published: November 2016

ABSTRACT
The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) that are embedded within the nuclear envelope, and control molecular exchange between the cytoplasm and nucleoplasm. In this Commentary, we discuss the biogenesis of these huge protein assemblies from approximately one thousand individual proteins. We will summarize current knowledge about distinct assembly modes in animal cells that are characteristic for different cell cycle phases and their regulation.
How cells respond to environmental cues – insights from bio-functionalized substrates
Authors: Ruprecht Verena , Monzo Pascale , Ravasio Andrea , Yue Zhang , Makhija Ekta , Strale Pierre Olivier , Gauthier Nils , Shivashankar G. V. , Studer Vincent , Albiges-Rizo Corinne , Viasnoff Virgile 
Published: November 2016

ABSTRACTBiomimetic materials have long been the (he)art of bioengineering. They usually aim at mimicking in vivo conditions to allow in vitro culture, differentiation and expansion of cells. The past decade has witnessed a considerable amount of progress in soft lithography, bio-inspired micro-fabrication and biochemistry, allowing the design of sophisticated and physiologically relevant micro- and nano-environments. These systems now provide an exquisite toolbox with which we can control a large set of physicochemical environmental parameters that determine cell behavior. Bio-functionalized surfaces have evolved from simple protein-coated solid surfaces or cellular extracts into nano-textured 3D surfaces with controlled rheological and topographical properties. The mechanobiological molecular processes by which cells interact and sense their environment can now be unambiguously understood down to the single-molecule level. This Commentary highlights recent successful examples where bio-functionalized substrates have contributed in raising and answering new questions in the area of extracellular matrix sensing by cells, cell–cell adhesion and cell migration. The use, the availability, the impact and the challenges of such approaches in the field of biology are discussed.
Dimension reduction of Malaria Box data allows efficient compound prioritization
Authors: Singh Gajinder Pal 
Published: November 2016

Background: New anti-malarial drugs are needed to meet the challenge of artemisinin resistance and to achieve malaria elimination and eradication. The new anti-malarial compounds are expected to have many desirable properties, such as activity against multiple stages of Plasmodium, low host cytotoxicity, and low propensity for resistance development, but whether and how these properties might be linked to each other is not clear. A better understanding of the relationship between activities of compounds against different stages of Plasmodium could help in the development of strategies to prioritize compounds with maximum potential for further development. Methods: We utilized the large amount of data that has recently been generated on 400 anti-malarial Malaria Box compounds and performed statistical analyses, such as rank correlation, hierarchical clustering, and principal-component analyses, to test associations between activities against different stages of Plasmodium, other pathogens, and human cells. Results: We found significant positive correlations between the activities of compounds against different stages of Plasmodium. Our results also show toxicity associated with assays conducted at higher compound concentrations. Principal-component analyses (PCA) of the data allowed differentiation of Plasmodium-specific activity from general toxicity and predicted success in in vitro evolution of resistance. We found that a single principal-component can capture most of the desirable properties of Malaria Box compounds and can be used to rank compounds from most desirable to least desirable activity-profile. Conclusions: Here, we provide a systematic strategy to prioritize Malaria Box compounds for further development. This approach may be applied for prioritization of anti-malarial compounds in general.
Superstition and Financial Decision Making
Authors: Hirshleifer David , Jian Ming , Zhang Huai 
Published: November 2016

In Chinese culture, certain digits are lucky and others unlucky. We test how such numerological superstition affects financial decision in the China initial public offering (IPO) market. We find that the frequency of lucky numerical stock listing codes exceeds what would be expected by chance. Also consistent with superstition effects, newly listed firms with lucky listing codes experience inferior post-IPO abnormal returns. Further tests suggest that our conclusions are not driven by endogeneity. This paper was accepted by Lauren Cohen, finance.
The support worker's role in equality, diversity and inclusion
Authors: Stonehouse David 
Published: November 2016

In this article, the author will be discussing the importance of equality, diversity and inclusion, and how support workers can promote these values within their care delivery. The Code of Conduct for Healthcare Support Workers and Adult Social Care Workers in England ( Skills for Care and Skills for Health, 2013 ) clearly states the importance of equality, diversity and inclusion, and the relevant clauses of the Code will be identified and discussed. The two key pieces of legislation, the Equality Act 2010 ( Ministry of Justice, 2010 ) and the Human Rights Act 1998 ( Ministry of Justice, 1998 ) will be discussed, identifying how these apply to the support worker's role. Where discrimination is occurring, the support worker will need to have the courage to speak out and challenge this bad and unlawful practice. Through promoting equality, diversity and inclusion, the support worker will be delivering care of the highest quality, as well as demonstrating respect and dignity to service users, their families and to colleagues.
Book reviews
Authors: McCollum Jean , Davison Peter , Marriott Janet D , Wilkinson Chris , Notter Joy , MacAlister Lynn , Sheehan Antony 
Published: November 2016

Emergency Nursing Review Keane's Essentials of Medical-Surgical Nursing (3rd edn) Budgeting Concepts for Nurse Managers (2nd edn) Quick ECG Interpretation: Nurse's Ready Reference The Sleep Book for Tired Parents Challenges in Caring: Explorations in Nursing and Ethics Basic Family Therapy (3rd edn)
Airway delivery of interferon‐γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice
Authors: Pasula Rajamouli , Britigan Bradley E. , Kesavalu Banurekha , Abdalla Maher Y. , Martin William J. 
Published: November 2016

AbstractMycobacterium avium (M. avium) causes significant pulmonary infection, especially in immunocompromised hosts. Alveolar macrophages (AMs) represent the first line of host defense against infection in the lung. Interferon gamma (IFN‐γ) activation of AMs enhances in vitro killing of pathogens such as M. avium. We hypothesized that airway delivery of AMs into the lungs of immunodeficient mice infected with M. avium will inhibit M. avium growth in the lung and that this macrophage function is in part IFN‐γ dependent. In this study, normal BALB/c and BALB/c SCID mice received M. avium intratracheally while on mechanical ventilation. After 30 days, M. avium numbers increased in a concentration‐dependent manner in SCID mice compared with normal BALB/c mice. Airway delivery of IFN‐γ‐activated BALB/c AMs or J774A.1 macrophages overexpressing IFN‐γ into the lungs of SCID mice resulted in a significant decrease in M. avium growth (P < 0.01, both comparisons) and limited dissemination to other organs. In addition, airway delivery of IFN‐γ activated AMs and macrophages overexpressing IFN‐γ increased the levels of IFN‐γ and TNF‐α in SCID mice. A similar protective effect against M. avium infection using J774A.1 macrophages overexpressing IFN‐γ was observed in IFN‐γ knockout mice. These data suggest that administration of IFN‐γ activated AMs or macrophages overexpressing IFN‐γ may partially restore local alveolar host defense against infections like M. avium, even in the presence of ongoing systemic immunosuppression.
Computer-assisted system on mandibular canal detection
Authors: Cheng Da-Chuan , Chen Li-Wei , Shen Yen-Wen , Fuh Lih-Jyh 
Published: November 2016

AbstractBackground:A dentist always checks a patient by using panoramic radiography (PR) initially. The measurement of the minimal distance (MD) between the alveolar crest and the mandibular canal (MC) superior border is critically important before the dental implant surgery, extraction of 3Objective:A software is needed for training dentists as well as a tool of demonstration to patients in clinics precisely and quickly. Moreover, it should be able to calculate the MD between the alveolar crest and the MC superior border before dental implant.Methods:A computer-aided software system to semi-automatically detect the MC and mental foramen (MF) in the PR with minimal human interference is proposed.Results:The result shows that the averaged relative error (RE) is 1.83% with a standard deviation of 2.31%.Conclusion:The results show that the proposed algorithm is able to detect the MC superior and inferior borders. This system has the potential to train young clinicians and to replace the manual work in measuring the MD between the alveolar crest and the MC superior border with a minimal human intervention.
Analysis of geothermal temperatures for heat
pumps application in Paraná (Brasil)
Authors: Santos Alexandre F. , de Souza Heraldo J. L. , Cantao Mauricio P. , Gaspar Pedro D. 
Published: November 2016

Abstract
Geothermal heat pumps are broadly used in developed
countries but scarcely in Brazil, in part because
there is a lack of Brazilian soil temperature data. The
aims of this work are: to present soil temperature measurements
and to compare geothermal heat pump system
performances with conventional air conditioning systems.
Geothermal temperature measurement results are shown
for ten Paraná State cities, representing different soil and
climate conditions. The measurements were made yearlong
with calibrated equipment and digital data acquisition
system in different measuring stations. Geothermal
and ambient temperature data were used for simulations
of the coeficient of performance (COP), by means of a
working fluid pressure-enthalpy diagram based software
for vapor-compression cycle. It was verified that geothermal
temperature measured between January 13 to October
13, 2013, varied from 16 to 24 °C, while room temperature
has varied between 2 and 35 °C. Average COP
values for conventional system were 3.7 (cooling mode)
and 5.0 kW/kW (heating mode), corresponding to 5.9 and
7.9 kW/kW for geothermal system. Hence it was verified an
average eficiency gain of 59%with geothermal system utilization
in comparison with conventional system.
Slender domains and compact domains
Authors: Jensen Christian U. , Jøndrup Søren , Thorup Anders 
Published: November 2016

Abstract
We prove that a one-dimensional Noetherian domain is slender if and only if it is not a local complete ring. The latter condition for a
general Noetherian domain characterizes the domains that are not algebraically compact. For a general Noetherian domain R we prove
that R is algebraically compact if and only if R satisfies a condition slightly stronger than not being slender. In addition we enlarge considerably the number of classes of rings for which the question of slenderness can be answered. For instance we prove that any domain, not a field, essentially of finite type over a field is slender.
Permutohedral structures on E2E_{2}-operads
Authors: Kaufmann Ralph M. , Zhang Yongheng 
Published: November 2016

Abstract
There are two interesting families of

E
2

{E_{2}}

-operads, those that detect double loop spaces, and those that solve Deligne’s conjecture on Hochschild cochains. The first family deformation retracts to Milgram’s model obtained by gluing together permutohedra along their faces. We show how the second family can be covered by permutohedra as well, shedding new light on several proposed solutions of Deligne’s conjecture. In particular, our approach induces an explicit homotopy equivalence between the models of the two families.
The permutohedra and partial orders play a central role providing direct links to other fields of mathematics. We for instance find a new cellular
decomposition of permutohedra using partial orders and that the permutohedra give the cells for the Dyer–Lashof operations.
Effect of Cr2O3 Pickup on Dissolution of Lime in Converter Slag
Authors: Yan Wei , Chen Weiqing , Zhao Xiaobo , Yang Yindong , McLean Alex 
Published: November 2016

AbstractApplication of low-nickel laterite ore containing chromium as charging material for ironmaking can reduce raw material costs, but result in an increase of chromium content in the hot metal and hence, Cr2O3 content in the steelmaking slag, which subsequently causes many problems related to lime dissolution for the steelmaking operation. In this work, a rotating cylinder method was employed to study the effect of Cr2O3 on lime dissolution in steelmaking slag. The lime dissolution mechanism, rate control step and affecting factors, including slag basicity, FeOx and B2O3 content, and the formation of phases at reacted layer, were discussed. It was found that mass transfer was the rate control step in slag phase, increase of Cr2O3 and slag basicity delayed lime dissolution due to the formation of high-melting temperature phases of FeO · Cr2O3 spinel and 2CaO · SiO2 at the slag/lime reacted interface. Addition of B2O3 promoted lime dissolution and suppressed formation of FeO · Cr2O3 spinel.
Dreams, aspirations and related constructs in children and adolescents: a literature review
Authors: Shek Daniel T.L. , Wu Florence K.Y. , Leung Hildie 
Published: November 2016

AbstractAlthough children and adolescents are often asked about their “dreams” about life, scientific studies of “dreams” and related constructs are grossly inadequate. This paper describes the findings arising from a review study exploring the concepts of dreams, aspirations and related constructs in children and adolescents. Besides an overview of the concept of dream, conceptual features and unique underpinnings of other concepts commonly related to dream, such as “aspirations”, “hope”, “future orientation” and “resilience” are presented in this paper. The research questions surrounding “dream” and related constructs in children and adolescents are presented and future research directions are discussed.
Bonny light crude oil-induced alteration in levels of testicular stress proteins is accompanied by apoptosis in rats after treatment withdrawal
Authors: Ebokaiwe Azubuike P. , Mathur Premendu P. , Farombi Ebenezer O. 
Published: November 2016

Abstract

Background:
The folkloric use of Bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders and as an anti-poison is a generally acceptable practice in the Niger Delta area of Nigeria. The testicular dysfunction induced by BLCO exposure is of public concern with a view to its folkloric usage. The present study investigated the effects of BLCO exposure and withdrawal on the levels of testicular stress proteins and apoptosis-related proteins in rats.

Methods:
Adult male Wistar rats were exposed to 800 mg/kg body weight of BLCO for 7 days. One-half of the rats in each group were sacrificed on day 8, while the remaining one-half stayed an additional 45 days without treatment.

Results:
Western blot analysis showed that administration of BLCO resulted in a significant increase in the levels of stress proteins and apoptosis-related proteins by 50% and above relative to control, except cytosolic nuclear factor-κB (NF-κB), which decreased significantly relative to control. This was followed by a concomitant increase in the expression of caspase-3, FasL, and NF-κB by immunofluorescence staining within the testicular germ cells. Apoptosis showed a significant increase in TUNEL-positive cells. Following withdrawal of treatment, BLCO-mediated alteration in stress proteins and induction of apoptosis persisted relative to control.

Conclusions:
Collectively, BLCO induced irreversible alteration in testicular stress proteins and apoptosis in rats within the time course of investigation. These findings highlight the potential long-term adverse effects of BLCO on individuals unduly exposed to BLCO.
Shock a disposable time in electronic security systems / Porażenie a czas dyspozycyjny w elektronicznych systemach bezpieczeństwa
Authors: Paś Jacek 
Published: November 2016

Abstract
This paper presents a method to determine the time TD disposable electronic security system that struck a pulse surges or lightning. Disposable time is the time from the moment of shock electronic security system until its transition to a state of security failures, assuming the impact of anti. Disruption (shock), which occurs in the frequency band (0-100) kHz, and effects on the ESB can be catastrophic is lightning.
Influence of flooding boat deck compartment on the training warship stability safety / Wpływ zatopienia pomieszczenia pokładu łodziowego na stateczność okrętu szkolnego
Authors: Mironiuk Waldemar 
Published: November 2016

Abstract
The paper presents computational stability issues with a flooded ship compartment situated on boat deck. As the main criteria for stability of the warship, calculation algorithm of metacentric height and righting levers have been defined, with a free surface effect taken into account. Based on the results of the calculations presented in tabular and graphical forms, suitable conclusions have been drawn up.
Validation of simulation model of the filling line failures / Walidacja modelu symulacyjnego uszkodzeń linii napełniania
Authors: Pawlewski Paweł , Jasiulewicz-Kaczmarek Małgorzata , Bartkowiak Tomasz , Hoffa-Dabrowska Patrycja 
Published: November 2016

Abstract
The main objective of the article is to present the methodology of validating a simulation model of failures of serial production line. In case of the investigated object, the simulation model was tested to find technological solutions which could compensate for the impact of failures on the operation of important objects present on the line before a failures occurs. A possible solution may be to introduce a new buffer or to adjust the size of existing buffers. Validation is one of the most significant stages in the process of constructing simulation models, as it concerns the credibility of the model. The article presents the use of disturbances modeling, especially breakdowns and micro-stoppages, in the simulation model. It also shows the statistical distribution applied in the model and defines the validation measurement instrument as well as evaluation criteria. All these features are the major strengths of the article.
On meromorphic functions for sharing two sets and three sets in m-punctured complex plane
Authors: Xu Hong-Yan , Zheng Xiu-Min , Wang Hua 
Published: November 2016

Abstract
In this article, we study the uniqueness problem of meromorphic functions in m-punctured complex plane Ω and obtain that there exist two sets S
1, S
2 with ♯S
1 = 2 and ♯S
2 = 9, such that any two admissible meromorphic functions f and g in Ω must be identical if f, g share S
1, S
2
I M in Ω.