bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUCOACTIVE THERAPY FOR PRODUCTIVE COUGH: CHOOSING THE DRUG
Authors:   Russian University of Medicine, Moscow, Russia, Babak S.L. , Gorbunova M.V. ,   Russian University of Medicine, Moscow, Russia, Karnaushkina M.A. ,   Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia, Borovitsky V.S. ,   Research Institute of the Federal Penitentiary Service, Moscow, Russia
Published: October 2024

Productive cough is the most common symptom for patients’ referrals to medical institutions. It is mainly caused by enhanced tracheobronchial secretion typical for most pulmonary diseases. In this context, the universal mechanisms of bronchopulmonary protection directly depend on the quality, rheological and protective properties of the mucins. That is why effective mucoactive therapy considers both diagnosis and properties of a mucoactive drug, which should affect the key components, production and transport of the bronchial mucus. This article represents a comprehensive review of mucin characteristics and two drugs, which are widely used in clinical practice – ambroxol and erdosteine.
The Role of HRM Functions in the Sustainable Performance of Pakistani Private Schools: A Post-Pandemic Status Quo Analysis
Authors: Saad Bin Aziz  , Sobia Iqbal  
Published: October 2024

The following quantitative study assess the role of HRM functions to drive the sustainable performance within the Pakistani private schools in the post-pandemic context. The COVID-19 pandemic has been able to fundamentally disrupt the educational decorum worldwide, forcing the schools to possibly adapt towards unprecedented issues. In this study, we investigate the ways in which HRM operations—including hiring and selection, training and development, performance reviews, and staff retention—have bolstered Pakistani private schools' resilience and long-term viability. Data was gathered from a representative sample of HR staff members, teachers, and administrators at private schools using a survey-based methodology. The association between HRM practices and sustainable school performance was determined by statistically analyzing the data with an emphasis on academic quality, staff well-being, and operational continuity.
The findings of the study reveal that effective HRM practices have played an important role to mitigate the negative influences of the pandemic, specifically through the strategic workforce planning, employee engagement, and professional development. Schools which adapted towards a proactive HRM approach exhibiting higher employee retention levels, rectified academic outcomes and job satisfaction in comparison to those with relatively less structured HR functions. The study presents that investment within the strong HRM functions is important to assure the sustainable performance of the educational institutions for the future crises. The research in consideration provides actionable insights related to the policymakers and school administrators to strengthen the HRM frameworks to increase the long-term viability of the private educational institutions in Pakistan.
NGHIÊN CỨU ỨNG DỤNG CÔNG NGHỆ UAV/RTK TRONG CÔNG TÁC THÀNH LẬP BẢN ĐỒ ĐỊA HÌNH TỶ LỆ LỚN TẠI KHU VỰC ĐỊA HÌNH PHỨC TẠP
Authors: Lê Thị Thu Hà 
Published: October 2024

Bản đồ địa hình được sử dụng rộng rãi trong lĩnh vực kinh tế, dân sự và cả quốc phòng. Độ chính xác bản đồ địa hình mang ý nghĩa về cả kỹ thuật lẫn kinh tế khi vừa cần cân bằng giữa phục vụ nhu cầu công việc và ngân sách đầu tư cho công tác đo vẽ, thành lập bản đồ. Mức độ phức tạp của địa hình, địa vật của khu vực đo sẽ gây ảnh hưởng lớn đến công tác đo vẽ ngoại nghiệp nếu sử dụng phương pháp đo đạc truyền thống. Mục tiêu của bài báo này đó là xây dựng được quy trình ứng dụng công nghệ bay không người lái có tích hợp định vị GNSS động (UAV/RTK) vào công tác đo vẽ thành lập bản đồ địa hình tỷ lệ lớn ở các khu vực có địa hình chênh cao phức tạp và có đa dạng địa vật. Các vấn đề này càng được quan tâm hơn nữa khi mà các bản đồ địa hình tỷ lệ 1/500 ở Việt Nam ở vùng miền khác nhau của cả nước nhưng cùng có chung đặc điểm là nằm ở khu vực địa hình đồi núi, phức tạp, có sự thay đổi lớn về chênh cao địa hình, có đa dạng các loại địa vật đặc trưng, các đặc điểm này ảnh hưởng lớn đến độ chính xác của kết quả mô hình số độ cao thành lập được từ dữ liệu bay chụp UAV.
WHEN IP MEETS NFTs: THE CASE FOR INTELLECTUAL PROPERTY PROTECTION FOR NON-FUNGIBLE TOKENS
Authors: Chinmay  
Published: October 2024

The world has seen enormous disruption by new age technologies in every domain of today's economy including the arena of art, music and entertainment. Furthermore, the impact of artificial intelligence and blockchain technology particularly the Non Fungible Tokens (NFTs) has overwhelmed scholars about their understanding of laws related to intellectual property. Advances in technology are expanding the scope of intellectual property beyond traditional patents, trademarks, designs, trade secrets, plant breeders' rights, and more. Various issues related to intellectual property have taken centre stage in the world of NFTs and Blockchains. Intellectual property disputes over virtual goods and NFTs are on the rise, and countries across the world are endeavoring to address the issues related to the protection of virtual goods. This article analyses the nature and scope of protection granted to virtual goods and NFTs in major jurisdictions viz the US and China. Further, the article analyses if the provisions of Indian IP Laws particularly the Trademarks and Designs Acts are sufficient to grant protection to the virtual goods.
Repercussões neurológicas da deficiência materna de vitamina B12 na infância
Authors: Carneiro Monalyza Pontes , Morais Maria Clara de Sousa , Turbano Myrella Evelyn Nunes , Turbano Mylla Christie Nunes , Turbano Yuri Samuel Nunes , Silva Mariana Maria da , Leal Marcus César Leandro da Silva , Henriques Carolina Gianoto , Menezes Letícia Maria Santos de , Santos Bruna Gonçalves dos , Santos Sarah Lisboa dos , Silva Rony Kesley Lima , Aguiar Alberto Ferreira Rocha de 
Published: October 2024

INTRODUÇÃO: A vitamina B12, conhecida como cobalamina, representa um dos oito tipos de vitaminas do complexo B, é essencial para saúde humana, pois participa na síntese de ácidos nucleicos, eritrócitos e na manutenção dos níveis de mielina. A deficiência de vitamina B12 em bebês que são alimentados exclusivamente de leite maternos de mães veganas possuem maior associação com atraso neurológico, associado a alterações hematológicas, como pancitopenia ou apenas megaloblastose. OBJETIVOS: Investigar e analisar as repercussões neurológicas associadas à deficiência materna de vitamina B12 durante a infância. METODOLOGIA: O presente estudo se trata de uma pesquisa de avaliação bibliográfica, por meio de uma revisão integrativa de literatura, de abordagem qualitativa e um estudo retrospectivo. Nesse Sentido, para o alcance do objetivo proposto, foi realizada pesquisas de artigos científicos através de bases de dados com o PubMed/MedLine (National Library of Medicine), Scielo (Scientific Electronic Library Online) e Cochane Library entre os anos de 2018 a 2023. RESULTADOS E DISCUSSÃO: Foram selecionados 5 artigos, no qual observou se que a deficiência materna de vitamina B12 está relacionada ao maior risco de complicações comuns da gravidez, incluindo aborto espontâneo, aborto recorrente, defeitos do tubo neural, restrição de crescimento intrauterino, com feto pequeno para a idade gestacional e baixo peso ao nascer. Além disso, as manifestações típicas da deficiência de vitamina B12 em crianças incluem falha no desenvolvimento do cérebro e no crescimento e desenvolvimento geral, hipotonia, dificuldades de alimentação, tremores, hiperirritabilidade e até mesmo coma, sendo que imagens do cérebro podem revelar atrofia e atrasos na mielinização. CONCLUSÃO: A conscientização sobre a importância da vitamina B12 durante a gestação e a infância, juntamente com medidas preventivas, como a suplementação adequada, são essenciais para garantir um desenvolvimento neurológico ótimo e reduzir o risco de complicações neurológicas ao longo da vida.
Symbolic Representation in the Traditional Ceremony at the Benuaq Dayak of East Kalimantan in Korrie Layun Rampan’s Ceremony Novel
Authors: Muhajir Fatimah M 
Published: October 2024

Benuaq Dayak is an ethnic group originating from Kutai Kertanegara, East Kalimantan. The uniqueness of the Benuaq Dayak community traditions is represented in a novel entitled Ceremony written by Korrie Layun Rampan. This novel displays the cultural background of the Dayak people in the interior of Kalimantan. It describes a series of ceremonies performed by the Dayak people in their social life. Various traditional ceremonies in this tribe still exist today. This study uses a qualitative descriptive method and uses symbolic theory to examine the meaning of several features of Benuaq Dayak traditional ceremonies. The results of the study show several kinds of symbolic features in ceremonies such as: Balian dance presents symbolic meanings as a form of hope, Kewangkey ceremony represents social esteem. Nalin Taun embodies the purification of the soul and forgiveness of sins, the last one is Pelulung or marriage ceremony which is followed by a gantar which symbolizes happiness and a symbol of friendship between the two villages.
Polarizing Uses of Older Age
Authors: Wohlmann Anita 
Published: October 2024

The Forum in Issue 8 of Age, Culture, Humanities is dedicated to the timely topic of the 2024 US American presidential elections, where the role of older age has loomed over the campaign. We invited distinguished colleagues from the USA, Canada, and Denmark to contribute short comments and reflections from an age studies perspective. Eight of them accepted, despite the short deadline, and their essays were published in instalments from mid-April to mid-July 2024.
In this introduction, I expand on one topic that popped up again and again, namely the polarizing tendencies many observed in the current discourse. I ask: What is the role of age in the context of polarization?
A preliminary study of carbon dioxide and methane emissions from patchy tropical seagrass meadows in Thailand
Authors: Halim Muhammad , Stankovic Milica , Prathep Anchana 
Published: October 2024

Background
Seagrass meadows are a significant blue carbon sink due to their ability to store large amounts of carbon within sediment. However, the knowledge of global greenhouse gas (GHG) emissions from seagrass meadows is limited, especially from meadows in the tropical region. Therefore, in this study, CO2 and CH4 emissions and carbon metabolism were studied at a tropical seagrass meadow under various conditions.

Methods
CO2 and CH4 emissions and carbon metabolism were measured using benthic chambers deployed for 18 h at Koh Mook, off the southwest coast of Thailand. The samples were collected from areas of patchy Enhalus acoroides, Thalassia hemprichii, and bare sand three times within 18 h periods of incubation: at low tide at 6 pm (t0), at low tide at 6 am (t1), and at high tide at noon (t2).

Results
Seagrass meadows at Koh Mook exhibited varying CO2 and CH4 emissions across different sampling areas. CO2 emissions were higher in patchy E. acoroides compared to patchy T. hemprichii and bare sand areas. CH4 emissions were only detected in vegetated areas (patchy E. acoroides and T. hemprichii) and were absent in bare sand. Furthermore, there were no significant differences in net community production across sampling areas, although seagrass meadows were generally considered autotrophic. Koh Mook seagrass meadows contribute only slightly to GHG emissions. The results suggested that the low GHG emissions from Koh Mook seagrass meadows do not outweigh their role as significant carbon sinks, with a value 320 t CO2−eq. This study provided baseline information for estimating GHG emissions in seagrass meadows in Thailand.
Cyclization of Vinyl and Aryl Azides into Pyrroles, Indoles, Carbazoles, and Related Fused Pyrroles
Authors: Berkowitz William F. , McCombie Stuart W. 
Published: June 2017

AbstractThis chapter reviews in detail those reactions that form of a new pyrrole ring from vinyl, aryl, and heteroaryl azides via formal C–H insertion processes under thermal, photochemical, and metal‐catalyzed conditions. These reactions proceed via the intermediacy of vinyl or aryl nitrenes (or their metallonitrene equivalents) and generate a wide variety of pyrroles, indoles, carbazoles, and related systems. Methods for the synthesis of the starting azides are summarized, and a comprehensive survey of the cyclization processes is provided.
Snipper, an Eri1 homologue, affects histone mRNA abundance and is crucial for normal Drosophila melanogaster development
Authors: Alexiadis Anastasios , Delidakis Christos , Kalantidis Kriton 
Published: June 2017

The conserved 3′–5′ RNA exonuclease ERI1 is implicated in RNA interference inhibition, 5.8S rRNA maturation and histone mRNA maturation and turnover. The single ERI1 homologue in Drosophila melanogaster Snipper (Snp) is a 3′–5′ exonuclease, but its in vivo function remains elusive. Here, we report Snp requirement for normal Drosophila development, since its perturbation leads to larval arrest and tissue‐specific downregulation results in abnormal tissue development. Additionally, Snp directly interacts with histone mRNA, and its depletion results in drastic reduction in histone transcript levels. We propose that Snp protects the 3′‐ends of histone mRNAs and upon its absence, histone transcripts are readily degraded. This in turn may lead to cell cycle delay or arrest, causing growth arrest and developmental perturbations.
Computerized Optimization of Liquid Chromatography Separations
Authors: Torrijos Rafael Cela , Romero Sara Triñanes 
Published: June 2017

Abstract
Computer‐assisted methods development (CAMD) of LC (liquid chromatography) separations comprises the strategies, methodologies, and software that can be used for more effective and efficient development of separations needed in the analytical chromatography laboratory. Substitution of costly and time‐consuming experiments by simulation, based on accurate regression models, provides a quick and convenient mode of testing hypothesis, verification, and reaching accurate conclusions in a period of seconds or minutes rather days or weeks of patient experimentation. Having been developed during the past four decades, CAMD provides actually several approaches that tackle separation problems both for mixtures in which all compounds are known (so the position of peaks in the experiments can be tracked) and for mixtures having a number of unknown components or components that cannot be tracked accurately. A chromatographer can select among a variety of more or less intuitive objective functions to adapt the performance of CAMD procedures to its goals. Software tools have made use of the advances in informatics and computation to provide user‐friendly and efficient graphical interfaces, relieving the chromatographer from making complex calculations, statistical testing of the reliability of simulations, and facilitating the interpretation of results. CAMD is not, and was never, intended to replace the chromatographers but to bring tools to make their work more efficient and facilitate the work of less‐experienced ones. Conveniently used, CAMD tools can help the analyst do a better job in a record time.
A Porphyrin Complex as a Self‐Conditioned Electrode Material for High‐Performance Energy Storage
Authors: Gao Ping , Chen Zhi , Zhao‐Karger Zhirong , Mueller Jonathan E. , Jung Christoph , Klyatskaya Svetlana , Diemant Thomas , Fuhr Olaf , Jacob Timo , Behm R. Jürgen , Ruben Mario , Fichtner Maximilian 
Published: June 2017

AbstractThe novel functionalized porphyrin [5,15‐bis(ethynyl)‐10,20‐diphenylporphinato]copper(II) (CuDEPP) was used as electrodes for rechargeable energy‐storage systems with an extraordinary combination of storage capacity, rate capability, and cycling stability. The ability of CuDEPP to serve as an electron donor or acceptor supports various energy‐storage applications. Combined with a lithium negative electrode, the CuDEPP electrode exhibited a long cycle life of several thousand cycles and fast charge–discharge rates up to 53 C and a specific energy density of 345 Wh kg−1 at a specific power density of 29 kW kg−1. Coupled with a graphite cathode, the CuDEPP anode delivered a specific power density of 14 kW kg−1. Whereas the capacity is in the range of that of ordinary lithium‐ion batteries, the CuDEPP electrode has a power density in the range of that of supercapacitors, thus opening a pathway toward new organic electrodes with excellent rate capability and cyclic stability.
Antimony Complexes for Electrocatalysis: Activity of a Main‐Group Element in Proton Reduction
Authors: Jiang Jianbing , Materna Kelly L. , Hedström Svante , Yang Ke R. , Crabtree Robert H. , Batista Victor S. , Brudvig Gary W. 
Published: June 2017

AbstractMain‐group complexes are shown to be viable electrocatalysts for the H2‐evolution reaction (HER) from acid. A series of antimony porphyrins with varying axial ligands were synthesized for electrocatalysis applications. The proton‐reduction catalytic properties of TPSb(OH)2 (TP=5,10,15,20‐tetra(p‐tolyl)porphyrin) with two axial hydroxy ligands were studied in detail, demonstrating catalytic H2 production. Experiments, in conjunction with quantum chemistry calculations, show that the catalytic cycle is driven via the redox activity of both the porphyrin ligand and the Sb center. This study brings insight into main group catalysis and the role of redox‐active ligands during catalysis.
Increasing ethnic diversity moderates longitudinal effects of individual differences on friendship homophily
Authors: Jugert Philipp , Rutland Adam , Brown Rupert , Cameron Lindsey , Nigbur Dennis , Watters Charles , Hossain Rosa , Landau Anick , Le Touze Dominique 
Published: June 2017

AbstractThis study examined direct and interactive effects of social–emotional adjustment, national and ethnic identification, and school ethnic composition on friendship homophily among 214 ethnic minority and 183 ethnic majority English children, aged between 5 and 11 years. The data came from a longitudinal study, which included 3 time points, spanning a 12‐month period. Results of multilevel latent growth curve models showed that among ethnic minority English children (teacher‐rated), peer problems and ethnic identity were associated with more friendship homophily, whereas a bicultural identity was not related to more friendship homophily. Among ethnic majority English children, the effects of peer problems and English identity were moderated by school ethnic composition, such that these factors were not associated with more friendship homophily in more ethnically diverse schools. The findings are discussed on the basis of theories of intergroup contact and intergroup threat.
Microcontact Peeling: A Cell Micropatterning Technique for Circumventing Direct Adsorption of Proteins to Hydrophobic PDMS
Authors: Yokoyama Sho , Matsui Tsubasa S. , Deguchi Shinji 
Published: June 2017

AbstractMicrocontact printing (μCPr) is one of the most popular techniques used for cell micropatterning. In conventional μCPr, a polydimethylsiloxane (PDMS) stamp with microfeatures is used to adsorb extracellular matrix (ECM) proteins onto the featured surface and transfer them onto particular areas of a cell culture substrate. However, some types of functional proteins other than ECM have been reported to denature upon direct adsorption to hydrophobic PDMS. Here we describe a detailed protocol of an alternative technique––microcontact peeling (μCPe)––that allows for cell micropatterning while circumventing the step of adsorbing proteins to bare PDMS. This technique employs microfeatured materials with a relatively high surface energy such as copper, instead of using a microfeatured PDMS stamp, to peel off a cell‐adhesive layer present on the surface of substrates. Consequently, cell‐nonadhesive substrates are exposed at the specific surface that undergoes the physical contact with the microfeatured material. Thus, although μCPe and μCPr are apparently similar, the former does not comprise a process of transferring biomolecules through hydrophobic PDMS. © 2017 by John Wiley & Sons, Inc.
Effect of Food Intake on the Pharmacokinetics of a Novel Methylphenidate Extended‐Release Oral Suspension for Attention Deficit Hyperactivity Disorder
Authors: Sallee Floyd R. , Palumbo Donna R. , Abbas Richat , Berry Sally A. , Puthli Shivanand P. , Kathala Kalyan K. 
Published: June 2017

AbstractWe conducted an open‐label, single‐dose, randomized, crossover study in healthy adults to assess the impact of food on the bioavailability of 60 mg methylphenidate extended‐release oral suspension (MEROS; Quillivant XR™)—a long‐acting stimulant for the treatment of attention deficit hyperactivity disorder—by comparing the pharmacokinetic parameters under fed and fasting conditions. When MEROS 60 mg was administered under fed conditions compared with fasting conditions, the exposure of methylphenidate (d enantiomer) was higher, with a mean area under the plasma concentration‐vs‐time curve (AUC)0–t of 160.2 ng·h/mL vs 140.4 ng·h/mL, and a mean AUC0–inf of 163.2 ng·h/mL vs 143.7 ng·h/mL, respectively. The ratios of the ln‐transformed geometric means for methylphenidate for AUC0–t and AUC0–inf were 119.5% (90%CI, 115.7% to 123.5%) and 119.0% (90%CI, 115.2% to 122.8%), respectively, within the standard 80% to 125% bioequivalence acceptance range indicating no food effect on the overall exposure (rate and extent). There was a small increase in the peak plasma concentration (127.6% [90%CI, 119.9% to 135.8%]). However, this effect was small and not likely to be clinically significant. Overall, MEROS 60 mg was safe in both the fed and fasting condition when administered to healthy volunteers in this study.
Plant Microbiome Identification and Characterization
Authors: Lebeis Sarah L. 
Published: June 2017

AbstractTo fully exploit the potential of plant microbiome alterations to improve plant health, reliable methods must be used to prepare and characterize microbiome samples. The power of culture‐independent studies is that they allow the characterization of novel microbial community members, but only microbial members consistently represented between different research groups are likely to become broadly applicable treatments. The identification of plant microbiome members can be affected by several experimental stages, including design, sample preparation, nucleic acid extraction, sequencing, and analysis. The protocols described here therefore aim to highlight crucial steps that experimenters should consider before beginning a plant microbiome study. © 2017 by John Wiley & Sons, Inc.
A Method of Shared File Cache for File Clone Function to Improve I/O Performance for Virtual Machines
Authors: KAMEI HITOSHI , YASHIRO OSAMU , NAKAMURA TAKAKI 
Published: June 2017

SUMMARYWe propose a method for shared file cache function for cloned files used by virtual machines, called SCC. The file clone function copies the files faster than conventional (read and write) method. Moreover, the function reduces disk spaces. The function is used to deploy virtual machines in virtual desktop infrastructure because of fast copying a lot of virtual machine disk files. SCC uses the file cache of a shared file as a shared cache among cloned files. The cached data on the shared file are returned to application programs on accessing the shared file via cloned files. Therefore, SCC improves the I/O performance of the shared file due to avoiding disk accesses. In this paper, we implement SCC and evaluate the I/O performance. From the evaluation, we have found SCC improves I/O throughput about 38 times in the case of random read and shared cache hit.