bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syn‐collision Biotite Hornblende Granodiorite from the Zedong Area, Tibet: Zircon U–Pb Isotope Chronology, Petro‐geochemistry, and Geodynamic Significance
Authors: ZHU Feilin , SHI Zeming , XIONG Fuhao , NI Shijun , BAI Mei 
Published: April 2017

AbstractCu–Au mineralization is rare in the Jurassic–Early Tertiary batholiths related to the India–Asia collision. Geochemical analysis and U–Pb isotope chronology was carried out on Shuangbujiere biotite hornblende granodiorite from the Zedong area. Zircon grains of the biotite hornblende granodiorite show oscillatory growth zonation and have high Th/U ratios of 1.08–2.39, indicating a magmatic origin for the zircons. Geochrological test yielded a LA‐ICP‐MS U‐Pb age of 51.5±1.0 Ma, suggesting that the emplacement age of the biotite hornblende granodiorite is Early Eocene. The Shuangbujiere biotite hornblende granodiorites have geochemical features characteristic of adakite and are associated with a calc–alkaline metaluminous I‐type granite enriched in Sr, high in Mg# (49.6–54.9) and Sr/Y, and depleted in Y and Yb. These results indicate that this intrusion formation may have been associated with crustal thickening caused by the early collision of the Indian and Eurasian Plates. As the process of crustal thickening continued, the heating of the underplated basaltic magma caused the thickened lower crust amphibolite to dehydrate the melt and form a high‐K calc–alkaline adakitic melt at about 848°C. Meanwhile, magma mixing of the underplated basaltic melt and high‐K calc–alkaline adakitic melt formed a high‐Mg# adakite representative of the sys‐collisional tectonic setting.
Geology, Geochemistry and Zircon U‐Pb Geochronology of Porphyries in the Dabate Mo‐Cu Deposit, Western Tianshan, China: Petrogenesis and Tectonic Implications
Authors: DUAN Shigang , ZHANG Zuoheng , WANG Dachuan , LI Fengming 
Published: April 2017

AbstractThe Dabate Mo‐Cu deposit is a medium‐sized porphyry‐type deposit in the Sailimu Lake region, western Tianshan, China. We present the geology, geochemistry and zircon U‐Pb geochronology of granite porphyries from the Dabate district with the intent to constrain their tectonic setting and petrogenesis. Porphyries in the Dabate district include granite porphyry I (gray white color with large phenocrysts), granite porphyry II (pink color with small phenocrysts) and quartz porphyry. Granite porphyry II is the Cu and Mo ore‐bearing granitoid in the Dabate deposit. LA‐ICPMS zircon U‐Pb analyses indicate that granite porphyry II was emplaced at 284.2±1.8 Ma. Granite porphyry I and II have similar geochemical features and are both highly fractionated granites: (1) They have high SiO2 content (70.93–80.18 wt% and 72.14–72.64 wt%, respectively), total alkali (7.58–8.95 wt% and 9.35–9.68 wt%, respectively), mafic index (0.95–0.98 and 0.93–0.94, respectively) and felsic index (0.79–0.94 and 0.89–0.91, respectively); (2) They are characterized by pronounced negative Eu anomaly, “seagull‐style” chondrite‐normalized REE patterns and “tetrad effect” of REE; (3) They are rich in Rb, K, Th, Ta, Zr, Hf, Y and REE, but depleted in Sr, P, Ti and Nb. The magma of granite porphyries in Dabate can be interpreted to have been generated by partial melting of the upper crust due to mantle‐derived magma underplating in a post‐collisional extensional setting.
Petrogenesis and Tectonics of the Naruo Porphyry Cu(Au) Deposit Related Intrusion in the Duolong Area, Central Tibet
Authors: DING Shuai , CHEN Yuchuan , TANG Juxing , ZHENG Wenbao , LIN Bin , YANG Chao 
Published: April 2017

AbstractThe Duolong area is the most important part of the Western Bangong‐Nujiang Suture Zone porphyry Cu(Au) metallogenic belt, in Tibet, China. Here new detailed data are presented from LA‐ICP‐MS zircon U‐Pb, whole‐rock geochemical, and in‐situ zircon Hf isotope analyses for igneous rocks in the large Naruo deposit (2.51 Mt of Cu and 82 t of Au) which is located ∼2 km NE of the Duolong (Duobuza and Bolong) super‐large gold‐rich porphyry copper deposit. We integrated our results with previous research of other porphyry deposits in the Duolong area and have identified the timing, geodynamic setting, and petrogenesis of the mineralization‐associated magmatic events. Based on the measurements, the Duolong area porphyry Cu(Au) deposit formations are associated with Early Cretaceous intermediate‐felsic magmatism, which is consistent with U‐Pb zircon ages of 120 Ma. All the main intrusive rocks in the ore‐concentrated area have similar lithogeochemical characteristics; they show a relative enrichment in both light rare earth elements (LREEs) and large‐ion lithophile elements (LILEs: Rb, Ba, K, etc.) and relative depletion in both heavy rare earth elements (HREEs) and high field strength elements (HFSEs: Nb, Ta, Zr, Hf, etc.). Moreover, the granite porphyry shows positive εHf(t) values between 1.38–7.37 suggesting that magmas were potentially derived from the partial melting of a depleted mantle wedge that had been metasomatized by subducted slab‐derived fluids or melts. This paper points out that the formation of the porphyry‐epithermal Cu(Au) deposit in the Duolong area was dominated by northward subduction of the Bangongco Tethys Plate beneath the Qiangtang block in the Early Cretaceous (124–114 Ma), when the subducted oceanic crust reached 50–70 km underground and generated different degrees of phase transformation, which lead to a melt produced by dehydration of amphibole minerals, a metasomatized mantle wedge, and induced mantle partial melting that produced the magma. Those deposits occurred in a continental arc tectonic setting, which is similar to the continental margin arc environment of the ocean‐continent subduction setting of the Andes metallogenic belt in South America.
Three‐Dimensional In Situ Stress‐Field Simulations of Shale Gas Formations: A Case Study of the 5th Member of the Xujiahe Formation in the Xinchang Gas Field, West Sichuan Depression
Authors: LÜ Jing , ZHOU Wen , XIE Runcheng , SHAN Yuming , ZHANG Chong , XU Hao 
Published: April 2017

AbstractThis work established a geological model for the 5th member of the Xujiahe Formation (X5 member) in the Xinchang gas field of the West Sichuan Depression based on the lithological, structural and depositional properties, as well as logging and well completion data and drill‐core observations. Rock mechanical parameters were calculated according to rock mechanic experiments and rock mechanic interpretations from logging data. We also calculated the magnitudes and orientations of the in situ stresses based on acoustic emission tests, differential strain tests, fracturing behaviour and logging interpretations as well as anisotropy logging tests, borehole‐breakout measurements and well‐log data. Additionally, the present stress field of the X5 member was simulated using finite element numerical (FEM) simulation methods. The numerical simulation results indicate that the distributions of lithology and fractures are key factors that influence the present stress field. The stress field in the study area is discontinuous as a result of fractures and faults in the central and eastern areas. Stress is concentrated at the end sections and bends of faults, but dissipates with distance away from both sides of the faults. A longitudinal profile clearly demonstrates the zonality and continuity of the stress field and an increase with depth. The differential stress distribution is relatively uniform; however, large deviations occur in fracture zones.
Transurethral removal of a cystic urolith in a mare using a laparoscopic specimen pouch
Authors: Williamson AJ , McKinnon AO 
Published: April 2017

Case reportCystic urolithiasis is the most common form of urolithiasis reported in horses. In contrast to the gelding or stallion, clinical disease is less common in the mare and manual removal techniques are possible because of their shorter, wider urethral anatomy. However, these manual removal techniques can be traumatic and are limited by the size of the urolith. This report describes the use of a commercial laparoscopic specimen pouch to remove a cystic urolith in a mare.ConclusionThis approach may allow the extraction of larger uroliths per urethra in the mare, while affording some protection to the mucosa of the bladder neck and urethra.
Benefits of rituximab as a second‐line treatment for autoimmune haemolytic anaemia in children: a prospective French cohort study
Authors: Ducassou Stéphane , Leverger Guy , Fernandes Helder , Chambost Hervé , Bertrand Yves , Armari‐Alla Corinne , Nelken Brigitte , Monpoux Fabrice , Guitton Corinne , Leblanc Thierry , Fisher Alain , Lejars Odile , Jeziorski Eric , Fouissac Fanny , Lutz Patrick , Pasquet Marlène , Pellier Isabelle , Piguet Christophe , Vic Philippe , Bayart Sophie , Marie‐Cardine Aude , Michel Marc , Perel Yves , Aladjidi Nathalie 
Published: April 2017

SummaryChildhood autoimmune haemolytic anaemia (AIHA) requires second‐line immunosuppressive therapy in 30–50% of cases. It appears that rituximab is indicated in such circumstances. This prospective national study reports the practice, efficacy and tolerance of rituximab in children with isolated AIHA and AIHA in the setting of Evans syndrome (ES). Sixty‐one children were given rituximab between 2000 and 2014. The median interval from diagnosis to rituximab was 9·9 [interquartile range (IQR) 1·6–28·5] months. Forty‐six patients responded (75%) and the 6‐year relapse‐free survival (RFS) was 48%. Twenty patients relapsed at a median interval of 10·8 (IQR 3·9–18·7) months, rituximab allowed steroid withdrawal in 44/61 (72%) of children. In isolated AIHA, complete response and 6‐year RFS were significantly higher than in ES (P < 0·05). Ten out of 61 patients were infants, seven of who responded with a 6‐year RFS of 71%. Among patients without immunoglobulin substitution before rituximab, 4 are still receiving substitutions. Five patients died, including one potentially attributable to rituximab. This large observational series of childhood AIHA established the rituximab benefit‐risk ratio, allowing steroid withdrawal, with 37% of long‐term responders, mainly in isolated AIHA. All subgroups of patients drew benefit. Our long‐term results indicate the baseline to be challenged by new treatment approaches.
Agreement between finger plethysmography‐ and brachial oscillometry‐derived blood pressure measurements
Authors: Allan Philip D. , O'Donnell Terrence , Tzeng Yu‐Chieh 
Published: April 2017

SummaryPurposeBlood pressure (BP) is commonly assessed by brachial oscillometry in clinical practice, whereas in physiological studies, finger plethysmography is often employed. This study assessed the limits of agreement between BP metrics obtained from each device.MethodsIn 96 participants, we simultaneously recorded BP by brachial oscillometry (BP+; Uscom, Sydney, NSW, Australia) and finger plethysmography (Finometer MIDI, MLE1054‐V; Finapres Medical Systems B.V., Amsterdam, the Netherlands). Agreement between the two devices was assessed by correlation and Bland–Altman analysis. We assessed average BP differences between the two devices using the criteria of the Association for the Advancement of Medical Instruments (AAMI), which require systolic and diastolic BP differences to be within ≤5 ± 8 (mean ± SD).ResultsBland–Altman analysis showed wide limits of agreement (±~17 mmHg or greater) between finger‐derived brachial and oscillometric BP. Both systolic and mean BP exhibited positive proportional biases (both P<0·05). Systolic BP differed significantly between devices (7·4 ± 17·7 mmHg, P<0·001), which did not meet the AAMI criteria. No mean bias was observed for diastolic BP (−1·5 ± 8·6 mmHg, P = 0·097), and the SD of ±8·6 mmHg is potentially acceptable given the finger signal may be expected to capture biological variability in BP. Mean BP showed poor concordance (3·7 ± 10·5 mmHg, P<0·001).ConclusionsThese findings indicate that systolic and mean BP measurements made by brachial oscillometry do not agree with those from finger plethysmography. In contrast, diastolic BP values show acceptable agreement.
Hydration status influences the measurement of arterial stiffness
Authors: Caldwell Aaron R. , Tucker Matthew A. , Burchfield Jenna , Moyen Nicole E. , Satterfield Alf Z. , Six Ashley , McDermott Brendon P. , Mulvenon Sean W. , Ganio Matthew S. 
Published: April 2017

SummaryConsensus guidelines have attempted to standardize the measurement and interpretation of pulse wave velocity (PWV); however, guidelines have not addressed whether hydration status affects PWV. Moreover, multiple studies have utilized heat stress to reduce arterial stiffness which may lead to dehydration. This study utilized two experiments to investigate the effects of dehydration on PWV at rest and during passive heat stress. In experiment 1, subjects (n = 19) completed two trials, one in which they arrived euhydrated and one dehydrated (1·2[1·0]% body mass loss). In experiment 2, subjects (n = 11) began two trials euhydrated and in one trial did not receive water during heat stress, thus becoming dehydrated (1·6[0·6]% body mass loss); the other trial subjects remained euhydrated. Using Doppler ultrasound, carotid‐to‐femoral (central) and carotid‐to‐radial (peripheral) PWVs were measured. PWV was obtained at a normothermic baseline, and at a 0·5°C and 1°C elevation in rectal temperature (via passive heating). In experiment 1, baseline central PWV was significantly higher when euhydrated compared to dehydrated (628[95] versus 572[91] cm s−1, respectively; P<0·05), but peripheral PWV was unaffected (861[117] versus 825[149] cm s−1; P>0·05). However, starting euhydrated and becoming dehydrated during heating in experiment 2 did not affect PWV measures (P>0·05), and independent of hydration status peripheral PWV was reduced when rectal temperature was elevated 0·5°C (−74[45] cm s−1; P<0·05) and 1·0°C (−70[48] cm s−1; P<0·05). Overall, these data suggest that hydration status affects measurements of central PWV in normothermic, resting conditions. Therefore, future guidelines should suggest that investigators ensure adequate hydration status prior to measures of PWV.
Finger pressure adjustments to various object configurations during precision grip in humans and monkeys
Authors: Viaro Riccardo , Tia Banty , Coudé Gino , Canto Rosario , Oliynyk Andriy , Salmas Paola , Masia Lorenzo , Sandini Giulio , Fadiga Luciano 
Published: April 2017

AbstractIn this study, we recorded the pressure exerted onto an object by the index finger and the thumb of the preferred hand of 18 human subjects and either hand of two macaque monkeys during a precision grasping task. The to‐be‐grasped object was a custom‐made device composed by two plates which could be variably oriented by a motorized system while keeping constant the size and thus grip dimension. The to‐be‐grasped plates were covered by an array of capacitive sensors to measure specific features of finger adaptation, namely pressure intensity and centroid location and displacement. Kinematic measurements demonstrated that for human subjects and for monkeys, different plate configurations did not affect wrist velocity and grip aperture during the reaching phase. Consistently, at the instant of fingers‐plates contact, pressure centroids were clustered around the same point for all handle configurations. However, small pressure centroid displacements were specifically adopted for each configuration, indicating that both humans and monkeys can display finger adaptation during precision grip. Moreover, humans applied stronger thumb pressure intensity, performed less centroid displacement and required reduced adjustment time, as compared to monkeys. These pressure patterns remain similar when different load forces were required to pull the handle, as ascertained by additional measurements in humans. The present findings indicate that, although humans and monkeys share common features in motor control of grasping, they differ in the adjustment of fingertip pressure, probably because of skill and/or morphology divergences. Such a precision grip device may form the groundwork for future studies on prehension mechanisms.
Reduced community viral load does not coincide with a reduction in the rate of new HIV diagnoses and recent infections: data from a region of southern Italy
Authors: Monno L , Saracino A , Scudeller L , Santoro C , Brindicci G , Punzi G , Lagioia A , Lo Caputo S , Angarano G 
Published: April 2017

ObjectivesWe assessed whether changes in community viral load (CVL) over time were associated with the rate of new HIV diagnoses (NDs).MethodsHIV‐1‐positive individuals referred to our institute and permanently residing in our province were considered for inclusion in the study. A total of 861 HIV‐infected adults with at least one HIV RNA measurement (12 530 measurements in total) between 2008 and 2014 were included. Viraemia copy‐years were calculated from all HIV RNA values for each patient using the trapezoidal rule; multiple CVL indicators were considered. Total NDs and recent infections (< 1 year) were analysed separately. The association between NDs and CVL was tested by means of mixed Poisson models, with CVL as a fixed effect and year as a random effect.ResultsThe incidence of NDs was 2.28 per 100 000 residents in 2008 and 2.52 per 100 000 residents in 2014. Total numbers of NDs and recent infections did not vary significantly over time (P for trend 0.879 and 0.39, respectively). Mean HIV RNA decreased from 31 095.8 HIV‐1 RNA copies/mL in 2008 to 21 231.5 copies/mL in 2014 (P < 0.001); a downward trend was always observed regardless of the CVL indicator considered. Depending on the indicator, there were some differences in CVL by patient characteristics. The most substantial contributors to CVL appeared to be male individuals, men who have sex with men (MSM), non‐Italians, and untreated subjects (all P < 0.05). The relative risk of ND increased among Italians and MSM with an increasing proportion of subjects having an undetectable HIV RNA, and decreased in the same population with increasing levels of CVL.ConclusionsIn our setting, CVL represented a good marker of access to care and treatment; however, reduced CVL did not coincide with a reduction in the rate of NDs.
Antenatal maternal hepatitis B care is a predictor of timely perinatal administration of hepatitis B immunoglobulin
Authors: Le Suong T. T. , Sahhar Lukas , Spring Stephanie , Sievert William , Dev Anouk T. 
Published: April 2017

AbstractBackgroundMother‐to‐child transmission of hepatitis B virus continues to occur despite universal recommendations for neonatal immune prophylaxis therapy (IPT) and infant vaccination.AimTo characterise the risk factors for failure to provide timely IPT and completion of the infant hepatitis B vaccination schedule for children born to mothers with chronic hepatitis B (CHB).MethodsWe conducted a retrospective cohort study to assess compliance with universal guidelines for neonatal IPT for children born to CHB mothers at Monash Health, Australia from 2008 to 2013. These mothers were invited to participate in a telephone interview regarding post‐partum hepatitis B virus (HBV) care and infant vaccination status. Multivariate logistic regression analysis was utilised to identify the predictors for engagement with specialist HBV care, timely administration of IPT, completion of HBV vaccination schedule and serological testing of the baby.ResultsA total of 451 CHB mothers delivered 454 live births. HBV immunoglobulin (HBIg) was dispensed within 12 h in 79.52% of births. HBIg was not administered to eight neonates. Of the 451 women, 125 were interviewed: 88.8% of babies completed the vaccine schedule, and 19.2% of infants had post‐vaccination testing. Antenatal HBV care was independently associated with a greater likelihood of timely HBIg administration (odds ratio 1.64, P = 0.04, 95% CI: 1.03–2.61). There were no significant predictors for engagement with specialist HBV care, vaccine coverage or serological testing of the baby.ConclusionTargeted interventions to improve timely HBIg and completion of the vaccine schedule are recommended. All pregnant women with CHB should be referred for HBV‐specific antenatal care regardless of viral replicative status.
Claims of employment discrimination and worker voice
Authors: Bender Keith A. , Heywood John S. , Kidd Michael P. 
Published: April 2017

AbstractUsing the U.S. National Study of the Changing Workforce survey, we show that claims of racial and gender discrimination emerge less frequently in workplaces with established worker voice mechanisms. This result accords with the hypothesis that participation enhances perceptions of workplace fairness. We show that while having a supervisor of the same race or gender is associated with reduced discrimination claims, the role of voice tends to be larger when the race or gender of the supervisor is different from that of the worker. This suggests that voice may be particularly important in heterogeneous workplaces.
Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI‐H460 cells by repressing MAP kinase pathways and inflammatory mediators
Authors: Dai Bingling , Ma Yujiao , Wang Wenjie , Zhan Yingzhuan , Zhang Dongdong , Liu Rui , Zhang Yanmin 
Published: April 2017

AbstractHighly effective and attenuated dose schedules are good regimens for drug research and development. Combination chemotherapy is a good strategy in cancer therapy. We evaluated the antitumour effects of dihydroberberine combined with sunitinib (DCS) on the human non‐small cell lung cancer cell lines (NSCLC), A549, NCI‐H460, and NCI‐H1299 in vitro and in vivo. DCS showed synergic effects on NCI‐H460 cell proliferation, colony formation and transplantable tumour growth, which suggested dihydroberberine increases the sensitivity of lung carcinoma to sunitinib. Further studies indicated that DCS down‐regulated phosphorylation of JNK, p38, and NF‐κB in NCI‐H460 cells and tumours and suppressed the IκB and COX‐2 expression. In addition, DCS reduced the secretion of the pro‐inflammatory cytokine, interleukin‐1 (IL‐1), in tumours. Inhibition of p38 activation by DCS was a likely contributing factor in IL‐1 and COX‐2 down‐regulation. Consistent with these results, a genomewide microarray analysis found that DCS induced the expression of cell cycle signal molecules that are known to be affected by JNK and p38. The change of cell cycle, in turn, led to down‐regulation of JNK and p38, and further reduced IL‐1 secretion. Collectively, these findings highlight potential molecular mechanisms of DCS chemotherapeutic activity and suggest that DCS is an efficacious strategy in NSCLC therapy.