bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUMAN RESOURCES MANAGEMENT: THE DIFFICULTIES OF OVERCOMING THE BURDENS OF BUREAUCRATIC GRAVITY
Authors: Охотский  , Okhotskiy Evgeniy 
Published: March 2017

In presented to attention of readers article the author attempted to analyze the scientific relevance and practical relevance for the modern system of public administration the problems of bureaucracy and red tape. The article explores the basic qualitative characteristics and peculiarities of functioning of the state apparatus, the difficulties of optimization of style, performance, problematic and contradictory nature of overcoming corruption and bureaucratic pathologies, threats, dysfunctions and other deformations in the practice of human resource management and public administration in General. It is emphasized that at some point the corrupt and bureaucratic mechanisms become latent shadow control system, which resist very difficult. In the result remain on top of the bureaucracy, the corruption, the brutality, the callousness and irresponsibility, and at the bottom of legal nihilism, distrust in the sincerity of the authorities ‘ double standards. In confirmation are the concrete facts relevant statistical and sociological data. In parallel, we analyze the phenomenon of bureaucracy,
explores the essence of bureaucracy and corruption, their causes and origins, manifestations, shadow side and negative social consequences. This article presents some value judgments made appropriate generalizations and conclusions, analyzes the actions taken by the state for the improvement of personnel management and guidance of proper administrative procedure in the public administration and civil service. Formulated proposals which, in the opinion of the author, will help to more efficiently realize the tasks put by the state in terms of bureaucratic control and innovation updates of the struggle against formalism, assessorship, corruption and corporate reticence.
Maggot therapy for wound care in Iran: a case series of the first 28 patients
Authors: Mirabzadeh A. , Ladani M.J. , Imani B. , Rosen S.A.B. , Sherman R.A. 
Published: March 2017

Objective: The need for improved wound care is receiving considerable attention in the Islamic Republic of Iran. Beginning in 2003, maggot therapy (MT) became part of Iran's effort to advance its wound care technology. The first cohort of patients treated with MT was analysed to evaluate the use of this treatment. Method: Patients treated with MT at three hospitals in Tehran were analysed retrospectively. Primary outcomes were time to wound debridement and time to wound healing. Factors potentially influencing primary outcomes were also recorded, including demographic factors (such as age, race, gender), wound characteristics, underlying medical illnesses, and treatment attitudes. Results: We analysed 28 patients with 29 wounds. Most (55%) of the wounds were ischaemic, neuropathic or mixed-pathology foot ulcers in patients with diabetes. Half were considered unsalvageable. All were completely debrided and subsequently healed with MT, without amputation, grafts, or advanced interventions. Osteomyelitis was present in all cases before MT, but appeared to have been eradicated, without recurrence during at least three years' follow-up. The most common adverse events were malodour, with wound pain reported in two patients. All patients and therapists were pleased with their overall experience. Conclusion: Maggot therapy can provide advanced wound care even in resource-limited areas. Maggot therapy was very acceptable to the patients and their therapists.
What is animation? The ‘Six Blind Men and an Elephant’ conundrum
Authors: Matarazzo Vera 
Published: March 2017

Abstract
This article examines how to define animation. It aims to critique attempts to briefly define animation in its essence, through an examination of several quandaries and pitfalls related to such attempts, including their lines of reasoning, justifications and defining boundaries. It shows that definitions of animation are influenced by how individuals attempting a definition relate to animation (animators, scholars, critics, etc.). It concludes that most attempts to define animation succinctly resemble themselves and present similar problems, being inadequate to properly explain the term and its relation to live-action film. Since animation cannot be properly defined in these succinct formulations, a more comprehensive and developed definition is proposed.
Composição química e toxicidade do óleo essencial de eucalipto sobre o ácaro-rajado
Authors: Souza Lauana Pellanda de , ZAGO HUGO BOLSONI , Pinheiro Patrícia Fontes , Valbon Wilson Rodrigues , Zuim Vitor , Pratissoli Dirceu 
Published: March 2017

The spotted spider mite, Tetranychus urticae Koch, 1836 (Acari: Tetranychidae) is a polyphagous pest which causes extensive damage to Brazilian agriculture. The control of this pest is usually performed by synthetic origin products. Thus, the essential oils with acaricide property can be resources considered as an alternative to control this pest. The objective of this study was to identify the chemical composition and evaluate the fumigation toxicity of Eucalyptus citriodora (Hook.) KD Hill & LAS Johnson essential oil on T. urticae. The essential oil extraction was performed by hydrodistillation, usinga Clevenger type apparatus . The compounds identification was made comparing the obtained mass spectra with the available spectra in the database of the spectral library Willey 330,000 and by the Kovats index (IK), calculated for each compound. Adult female spotted spider mite were subjected to doses of 3.57, 7.14, 10.71, 14.28 and 17.85 μL L-1 of the essential oil air in fumigation chambers during 24, 48 and 72 hours. Subsequently, lethal concentration (LC50) of the essential oil was estimated. Ten compounds were identified, being the citronellal (68.20%) the major compound. The LC50 value observed after 24, 48 and 72 hours of exposure to essential oil were 17.55, 17.00 and 10.50 μL L-1 of air, respectively, and the fecundity of T. urticae females reduced with an increase of the used concentrations.
The awareness of Russians about iodine deficiency diseases and methods of it’s prevention
Authors: Melnichenko Galina A. , Troshina Ekaterina A. , Platonova Nadezhda M. , Savchuk Pavel O. , Yakunchikova Maria S. 
Published: March 2017

Обоснование: Среднее потребление йода жителем России в 3 раза меньше установленной нормы. Недостаточное потребление йода создает серьезную угрозу здоровью 100 млн. россиян, в том числе сохраняется угроза нарушения физического и умственного развития у 32,8 млн. детей, проживающих в Российской Федерации. Сложившаяся ситуация требует проведения систематической йодной профилактики.Цель: Оценка осведомленности россиян о йододефицитных заболеваниях, их последствиях и мерах профилактики, а так же формирование у граждан осознанной необходимости в сбалансированном употреблении йодированной соли и продуктов, богатых йодом.Методы: Проведение опроса россиян разной возрастной категории в рамках Всероссийской акции по профилактике йододефицитных заболеваний и подсчет полученных результатов.Результаты: В опросе приняли участие 34968 россиян. 54,4% респондентов употребляют в пищу йодированную соль. Информированность населения о йододефицитных заболеваниях в среднем составляет 62, 6%. В поддержку закона о всеобщем йодировании соли на производствах России выступили 66, 4% россиян.Заключение: Исходя из оценки полученных данных, даже среди лиц, осведомленных по вопросу йододефицитных заболеваний, далеко не все понимают значимость использования в пищу йодированной соли и влияние этого фактора на общую заболеваемость. С целью предупреждения распространения йодного дефицита и снижения риска развития его тяжелых последствий в России необходима организация системной массовой профилактики и повышение медицинской грамотности населения по данному вопросу.
Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas
Authors: Qiao X , Wang H , Wang X , Zhao B , Liu J 
Published: March 2017

Abstract
Microarray data of non-functioning pituitary adenomas (NFPAs) were analyzed to disclose novel genes and pathways involved in NFPA tumorigenesis. Raw microarray data were downloaded from Gene Expression Omnibus. Data pre-treatment and differential analysis were conducted using packages in R. Functional and pathway enrichment analyses were performed using package GOs-tats. A protein-protein interaction (PPI) network was constructed using server STRING and Cytoscape. Known genes involved in pituitary adenomas (PAs), were obtained from the Comparative Toxicogenomics Database. A total of 604 differentially expressed genes (DEGs) were identifed between NFPAs and controls, including 177 up- and 427 down-regulated genes. Jak-STAT and p53 signaling pathways were significantly enriched by DEGs. The PPI network of DEGs was constructed, containing 99 up- and 288 down-regulated known disease genes (e.g. EGFR and ESR1) as well as 16 up- and 17 down-regulated potential novel NFPAs-related genes (e.g. COL4A5, LHX3, MSN, and GHSR). Genes like COL4A5, LHX3, MSN, and GHSR and pathways such as p53 signaling and Jak-STAT signaling, might participate in NFPA development. Although further validations are required, these findings might provide guidance for future basic and therapy researches.
Is c.1431-12G>A A common European mutation of SPINK5? report of a patient with Netherton Syndrome
Authors: Śmigiel R , Królak-Olejnik B , Śniegórska D , Rozensztrauch A , Szafrańska A , Sasiadek MM , Wertheim-Tysarowska K 
Published: March 2017

Abstract
Netherton Syndrome (NS) is a very rare genetic skin disease resulting from defects in the SPINK5 gene (encoding the protease inhibitor lympho-epithelial Kazal type inhibitor 1, LEKTI1). In this report, we provide a detailed clinical description of a Polish patient with two SPINK5 mutations, the novel c.1816_1820+21delinsCT and possibly recurrent c.1431-12G>A. A detailed pathogenesis of Netherton Syndrome, on the basis of literature review, is discussed in the view of current knowledge about the LEKT1 molecular processing and activity.
Case report of a novel mutation of the EYA1 gene in a patient with branchio-oto-renal syndrome
Authors: Spahiu L , Merovci B , Ismaili Jaha V , Batalli Këpuska A , Jashari H 
Published: March 2017

Abstract
Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder characterized by the coexistence of branchial cysts or fistulae, external ear malformation with pre-auricular pits or tags, hearing impairment and renal malformations. However, the presence of the main features varies in affected families. Here, we present a 16-year-old boy admitted to the Department of Nephrology at the Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo because of severe renal insufficiency diagnosed 6 years ago, which progressed to end-stage renal failure. Clinical examination on readmission showed a pale, lethargic and edematous child, with auricular deformity, pre-auricular tags and pits as well as bilateral branchial fistulae. Laboratory tests revealed high blood urea nitrogen (BUN) 15.96 mmol/L and serum creatinine 633.0 µmol/L; low glomerular filtration rate (GFR) 12 mL/min./ 1.73 m2 and massive proteinuria 4+. Abdominal ultrasound showed bilateral kidney hypoplasia. A novel mutation of the EYA1 gene was confirmed. Daily hemodialysis is continuing until renal transplantation is done. This case is presented to increase awareness among general practitioners to consider BOR syndrome or other renal abnormalities in patients with branchial fistula and/ or external ear anomalies or similar findings in other family members.
Ambiguity related misunderstanding and clarity enhancing practices in ELF communication
Authors: Kaur Jagdish 
Published: March 2017

AbstractAs research into the use of English as a lingua franca (ELF) intensifies, questions on the implications of the findings for English Language Teaching (ELT) are increasingly being raised. In this regard, research on misunderstanding in ELF has much to offer ELT practitioners. Awareness of what causes misunderstanding means that learners can be trained to take relevant measures to avoid the triggers that contribute to the problem. Among these, ambiguity has been identified as a major source of ELF misunderstanding. This article investigates further the role of ambiguity in triggering misunderstanding and examines some of the practices speakers employ to increase the explicitness of what they say. Based on conversation analytic procedures, speakers were found to enhance the clarity of their talk through the use of a parenthetical remark that provides illustration, description, definition, and comparison of similarity or dissimilarity. Learning activities that provide learners with opportunities to use the aforementioned can contribute to developing in learners the ability to communicate effectively in lingua franca settings.
MHD Flow with Hall current and Joule Heating Effects over an Exponentially Stretching Sheet
Authors: Srinivasacharya D. , Jagadeeshwar P. 
Published: March 2017

AbstractThe aim of the present paper is to study the influence of Hall current and Joule heating on flow, heat and mass transfer over an exponentially stretching sheet in a viscous fluid. Using similarity transformations the governing nonlinear coupled equations are converted into ordinary differential equations. These equations are linearized using the successive linearization method and then solved using the Chebyshev pseudo spectral method. The influence of magnetic parameter, Hall parameter, suction/injection parameter and slip parameter on the physical quantities are presented graphically. The obtained results are compared with the previously published results for special cases.
Activity of Lower Limb Muscles During Squat With and Without Abdominal Drawing-in and Pilates Breathing
Authors: Barbosa Alexandre C. , Martins Fábio M. , Silva Angélica F. , Coelho Ana C. , Intelangelo Leonardo , Vieira Edgar R. 
Published: March 2017

Abstract
Barbosa, AC, Martins, FM, Silva, AF, Coelho, AC, Intelangelo, L, and Vieira, ER. Activity of lower limb muscles during squat with and without abdominal drawing-in and Pilates breathing. J Strength Cond Res 31(11): 3018–3023, 2017—The purpose of this study was to assess the effects of abdominal drawing-in and Pilates breathing on the activity of lower limb muscles during squats. Adults (n = 13, 22 ± 3 years old) with some Pilates experience performed three 60° squats under each of the following conditions in a random order: (I) normal breathing, (II) drawing-in maneuver with normal breathing, and (III) drawing-in maneuver with Pilates breathing. Peak-normalized surface electromyography of the rectus femoris, biceps femoris, gastrocnemius medialis, and tibialis anterior during the knee flexion and extension phases of squat exercises was analyzed. There were significant differences among the conditions during the knee flexion phase for the rectus femoris (p = 0.001), biceps femoris (p = 0.038), and tibialis anterior (p = 0.001), with increasing activation from conditions I to III. For the gastrocnemius medialis, there were significant differences among the conditions during the knee extension phase (p = 0.023), with increased activity under condition I. The rectus and biceps femoris activity was higher during the extension vs. flexion phase under conditions I and II. The tibialis anterior activity was higher during the flexion compared with the extension phase under all conditions, and the medial gastrocnemius activity was higher during the extension phase under condition I. Doing squats with abdominal drawing-in and Pilates breathing resulted in increased rectus, biceps femoris, and tibialis anterior activity during the flexion phase, increasing movement stability during squat exercises.
Effect of an 11-Week In-Water Training Program With Increased Resistance on the Swimming Performance and the Basic Kinematic Characteristics of the Front Crawl Stroke
Authors: Gourgoulis Vassilios , Valkoumas Ioannis , Boli Alexia , Aggeloussis Nikolaos , Antoniou Panagiotis 
Published: March 2017

Abstract
Gourgoulis, V, Valkoumas, I, Boli, A, Aggeloussis, N, and Antoniou, P. Effect of an 11-week in-water training program with increased resistance on the swimming performance and the basic kinematic characteristics of the front crawl stroke. J Strength Cond Res 33(1): 95–103, 2019—The purpose of the study was to assess the effect of an 11-week in-water training program with increased resistance on the swimming performance and the basic kinematic characteristics of the front crawl stroke in young female swimmers. Twelve swimmers were matched in pairs according to their best performance in 50-m front crawl swimming and then were randomly assigned to an experimental or to a control group. Both groups followed exactly the same swimming training program. The only exception was that the experimental group performed a sprint training section with increased resistance pulling a water parachute, whereas the control group performed the same section without parachute. Before and after the intervention program, the best performance of both groups in 50-, 100-, and 200-m front crawl swimming were assessed. Moreover, the basic kinematic characteristics of the stroke were calculated during 50-m front crawl swimming with maximal intensity. Two-way repeated measures analyses of variance revealed significant improvement in the best performance in all swimming distances only in the experimental group (3.22–7.26%). As far as the basic kinematic characteristics of the stroke are concerned, significant modifications were found only in the mean swimming velocity in the experimental group (2.18%), whereas no significant changes were observed in the stroke length, the stroke rate, and the duration of the propulsive, and nonpropulsive phases in both groups. Thus, the findings of the current study revealed a positive effect of the in-water resistance training program in the swimming performance of young female swimmers of moderate performance level, without any negative influence in the basic kinematic characteristics of the stroke.
Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules
Authors: Honda Atsuko , Ito Yasuyuki , Takahashi-Niki Kazuko , Matsushita Natsuki , Nozumi Motohiro , Tabata Hidenori , Takeuchi Kosei , Igarashi Michihiro 
Published: March 2017

Lipid raft domains, where sphingolipids and cholesterol are enriched, concentrate signaling molecules. To examine how signaling protein complexes are clustered in rafts, we focused on the functions of glycoprotein M6a (GPM6a), which is expressed at a high concentration in developing mouse neurons. Using imaging of lipid rafts, we found that GPM6a congregated in rafts in a GPM6a palmitoylation-dependent manner, thereby contributing to lipid raft clustering. In addition, we found that signaling proteins downstream of GPM6a, such as Rufy3, Rap2, and Tiam2/STEF, accumulated in lipid rafts in a GPM6a-dependent manner and were essential for laminin-dependent polarity during neurite formation in neuronal development.In uteroRNAi targeting of GPM6a resulted in abnormally polarized neurons with multiple neurites. These results demonstrate that GPM6a induces the clustering of lipid rafts, which supports the raft aggregation of its associated downstream molecules for acceleration of neuronal polarity determination. Therefore, GPM6a acts as a signal transducer that responds to extracellular signals.SIGNIFICANCE STATEMENTLipid raft domains, where sphingolipids and cholesterol are enriched, concentrate signaling molecules. We focused on glycoprotein M6a (GPM6a), which is expressed at a high concentration in developing neurons. Using imaging of lipid rafts, we found that GPM6a congregated in rafts in a palmitoylation-dependent manner, thereby contributing to lipid raft clustering. In addition, we found that signaling proteins downstream of GPM6a accumulated in lipid rafts in a GPM6a-dependent manner and were essential for laminin-dependent polarity during neurite formation.In uteroRNAi targeting of GPM6a resulted in abnormally polarized neurons with multiple neurites. These results demonstrate that GPM6a induces the clustering of lipid rafts, which supports the raft aggregation of its associated downstream molecules for acceleration of polarity determination. Therefore, GPM6a acts as a signal transducer that responds to extracellular signals.
TGFβ1‐induced leucine limitation uncovered by differential ribosome codon reading
Authors: Loayza‐Puch Fabricio , Rooijers Koos , Zijlstra Jelle , Moumbeini Behzad , Zaal Esther A , Oude Vrielink Joachim F , Lopes Rui , Ugalde Alejandro P , Berkers Celia R , Agami Reuven 
Published: March 2017

AbstractCancer cells modulate their metabolic networks to support cell proliferation and a higher demand of building blocks. These changes may restrict the availability of certain amino acids for protein synthesis, which can be utilized for cancer therapy. However, little is known about the amino acid demand changes occurring during aggressive and invasive stages of cancer. Recently, we developed diricore, an approach based on ribosome profiling that can uncover amino acid limitations. Here, we applied diricore to a cellular model in which epithelial breast cells respond rapidly to TGFβ1, a cytokine essential for cancer progression and metastasis, and uncovered shortage of leucine. Further analyses indicated that TGFβ1 treatment of human breast epithelial cells reduces the expression of SLC3A2, a subunit of the leucine transporter, which diminishes leucine uptake and inhibits cell proliferation. Thus, we identified a specific amino acid limitation associated with the TGFβ1 response, a vulnerability that might be associated with aggressiveness in cancer.
Modern Management of Anthracycline-Induced Cardiotoxicity in Lymphoma Patients: Low Occurrence of Cardiotoxicity with Comprehensive Assessment and Tailored Substitution by Nonpegylated Liposomal Doxorubicin
Authors: Olivieri Jacopo , Perna Gian Piero , Bocci Caterina , Montevecchi Claudia , Olivieri Attilio , Leoni Pietro , Gini Guido 
Published: March 2017

Abstract

Background
Anthracyclines (AC) are still undeniable drugs in lymphoma treatment, despite occasionally causing cardiotoxicity. Liposomal AC may reduce cardiotoxicity while retaining clinical efficacy; also, biomarker monitoring during chemotherapy allows early detection of cardiac damage, enabling strategies to prevent left ventricular ejection fraction (LVEF) deterioration.

Materials and Methods
We conducted a prospective observational trial in a real-life population of lymphoma patients, combining advanced echocardiography and biomarkers (Troponin I [TnI]) for early detection of cardiotoxicity; we applied a prespecified policy to minimize cardiotoxicity, selecting patients with higher baseline risk to replace doxorubicin with nonpegylated liposomal doxorubicin (NPLD) and starting cardioprotective treatment when subclinical cardiotoxicity was detected.

Results
Ninety-nine patients received ≥1 cycle of chemotherapy (39 with NPLD): 38 (NPLD = 34) were older than 65 years. At baseline, the NPLD subgroup had more cardiovascular risk factors and comorbidities than the doxorubicin subgroup. After treatment, echocardiographic parameters did not worsen in the NPLD subgroup; significant LVEF reduction occurred in two patients treated with doxorubicin. Over treatment course, TnI rises increased linearly in the doxorubicin subgroup but modestly in the NPLD subgroup. At doxorubicin doses &gt;200 mg/m2 the difference was statistically significant, with more TnI rises in the doxorubicin subgroup. NPLD-treated patients did not experience higher rates of grade 3–4 adverse events. Within the diffuse large B-cell lymphomas category, we observed similar rates of complete and overall responses between doxorubicin- and NPLD-treated patients.

Conclusion
A comprehensive strategy to prevent, detect, and treat cardiotoxicity allows an optimal management of the lymphoma with low incidence of cardiac complications.