bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indonesian Adolescents’ Perceptions of Front-of-package Labels on Packaged Food and Drinks
Authors: Gonzalez Wendy , Sari Eny Kurnia , Sutrisn Aang , Felix Zineb , Dibyasari Adhika Dwita , Ernada Nabila , Taillie Lindsey S. 
Published: October 2024

Abstract

Background
Indonesia faces a multi-faceted public health issue, with a shift in dietary patterns leading to increases in overweight and obesity. Unhealthy dietary behaviors arise with increased accessibility to ultra-processed foods and a concurrent drive towards increased autonomy.
Objective
To explore Indonesian adolescents’ drivers of food choice, perceptions of different front-of-package labels (FOPLs), and views on design features that could influence the impact of FOPLs.
Methods
Eight focus groups were conducted with 46 participants aged 12–18, of different socioeconomic status from Jakarta metropolitan areas. Three FOPLs were tested, and the selection of snacks was guided by interviews with four adolescents. The Pan American Health Organization (PAHO) nutrient profile and the UK nutrient profile were used for the warning label and traffic light label (TLL), respectively. Participants completed a demographics questionnaire, then an online assessment and discussion that encompassed food purchasing decisions, reactions to each of the FOPLs, comparison of FOPLs, and comparing alternative label designs for each FOPL type. Thematic analysis and the Likert scale were used for quantitative and qualitative analysis, respectively.
Results
Price, taste, and value were the major drivers of food purchasing. While most participants said the TLL would make them stop and think (57%) and helped them identify unhealthy food (80%), few believed the label would make them concerned about purchasing unhealthy food (37%). Few participants (35–37%) agreed that any of the three label types would make them not want to buy unhealthy foods or discourage them from purchasing unhealthy foods (26%-28%).
Conclusions
Traffic light and warning labels hold promise for helping adolescents in Indonesia identify unhealthy foods and discourage purchases of these products, while healthy icons are perceived as less effective.
Perception among doctors of Pakistan about using Bariatric Surgery in Morbidly Obese Patients
Authors: Abdullah Areeba Abdullah , Haroon Madiha , Siddiqi Faisal , Beg Mirza Arshad , Abidi Syeda Saroosh , Mansoor Javeria , Rehman Areeba 
Published: October 2024

Abstract

Introduction:
Obesity is a global epidemic, with Pakistan being the ninth most obese country, affecting one in four individuals. Literature suggests that less than 1% of eligible patients opt for bariatric surgery, indicating its underutilization. This is due to physicians' limited understanding of its effectiveness, which affects referral rates. This study aims to evaluate doctors' perceptions of bariatric surgery, including its benefits and complications.
Methods
This multicenter cross-sectional study, conducted from January to September 2024, included doctors of varying training levels and specialties. Data were collected using non-probability convenience sampling and analysed with STATA 17. P-value <0.05 was considered significant.
Results
Our study involved 414 doctors, mostly females (63.5%), aged 26-35 years (89.3%), with 0-5 years of experience (76.3%) and primarily from surgical and allied fields (44.4%). Nearly all respondents (96.8%) were aware of bariatric surgery as an effective weight loss tool, views on its safety varied, with 46.86% considering it safe and 21.98% viewing it as cosmetic. Complications were estimated by 41.06% to be 5-10%, and 40.1% thought they could be fatal. About 26.57% lacked confidence in discussing bariatric options, with gender-based differences (p=0.019). Most participants (90.82%), primarily from surgical and allied fields, felt more educational resources were needed, with differences across specialties (p=0.005).
Conclusion
In conclusion, although doctors acknowledge the effectiveness of bariatric surgery, concerns about safety and complications lead to reluctance in recommending it. Targeted education is essential for doctors to confidently counsel patients about bariatric surgery.
Identification of Alcoholic Hepatitis-related Genes using Liver and Blood Transcriptomes
Authors: Han Seul Ki , Lee Taesic , Lee Jin Suk , Lim Jisun , Kim Hyunsoo , Uh Young , Kim Moon Young 
Published: October 2024

Abstract

Background Alcoholic hepatitis (AH) is a widespread and life-threatening chronic liver condition that poses a risk of short-term mortality if not properly managed. Clinicians often encounter challenges due to insufficient knowledge about the underlying mechanisms of AH. This study employs a meta-analysis to identify the molecular mechanisms and potential cell therapy targets for AH. Methods We collected eight gene expression datasets, six from liver tissues and two from blood tissues, to identify AH-associated genes. Two liver datasets that had data on deaths after steroid treatment in patients with alcoholic hepatitis were also examined to uncover signatures associated with poor prognosis. Candidate genes were selected using the inverse weighted variance-based method implemented in the METAL software. We utilized prior knowledge to prioritize potential upstream genes, including a transcription factor (TF) catalog, protein-protein interaction (PPI) networks, disease-gene association databases, and summary statistics for single nucleotide polymorphisms (SNP) linked to disease and expression. Results Through four stepwise meta-analyses of nine gene expression datasets, we identified the robust AH liver genes. In detail, the first, second, third, and fourth steps of meta-analysis provided the liver-specific, liver-blood, and severe-mortality meta-genes linked to AH condition, respectively. Multiple lines of evidence (TF, PPI, and SNP databases) were used to identify 29 AH-related upstream genes. Among the candidates, 14 genes were replicated in the severe acute AH mouse model. Conclusions This study presented the candidate upstream AH genes, providing a foundation for developing AH therapeutic targets.
Comparative Outcomes of Unilateral versus Bilateral Cage Placement in Lumbar Interbody Fusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Stamiris Stavros , Stamiris Dimitrios , Anestiadou Elissavet , Sarridimitriou Athanasios , Cheva Angeliki , Loukousia Antonia , Vrangalas Vasileios , Christodoulou Pavlos , Karampalis Christos 
Published: October 2024

Abstract

Study design: Systematic review and meta-analysis
Objective: To compare the safety and efficacy of unilateral versus bilateral cage placement in lumbar interbody fusion.
Summary of background data: Lumbar interbody fusion is a common surgical procedure designed to treat chronic spinal conditions. The procedure often involves the use of intervertebral cages to increase stability and promote fusion. While bilateral cage placement has traditionally been favored, recent studies have questioned its necessity.
Methods: A comprehensive search across PubMed, Scopus, and Cochrane databases identified eight eligible RCTs involving 509 patients. The primary outcome focused on the spinal fusion rate, whereas the secondary outcomes included surgery related outcomes (operative time, estimated blood loss, length of stay), patient-reported outcomes (visual Analog Scale, Oswestry Disability Index, patient satisfaction) and complications.
Results: The analysis revealed no significant difference in successful spinal fusion rates between the two groups (p=0.41). Unilateral cage placement was associated with significantly shorter operation time (p<0.0001) and reduced estimated blood loss (p<0.0001), whereas hospital stay was not affected by the number of cages used (p=0.24). Patient-reported outcomes, including VAS back score (p=0.61), VAS leg score (p=0.64), ODI score (p=0.23) and patient rate of results (p=0.55) showed no substantial differences between the two groups. Patients in the unilateral group had a lower overall risk for complications (p=0.03), but no difference in the risk of cage migration was noted between the two groups (p=0,97).
Conclusions: Unilateral cage placement in lumbar interbody fusion is as effective as bilateral for achieving fusion without compromising patient outcomes. Furthermore, offers significant advantages, including reduced operative time, blood loss and reduced risk for complications.
Plywood Proficiency: Navigating Quality Assurance in Manufacturing
Authors: Vashishtha Shwet Raj 
Published: October 2024

Abstract

Proficiency testing (PT) is a critical tool for quality assurance in plywood manufacturing, ensuring that products meet the necessary quality benchmarks and are fit for purpose. This study investigates the effectiveness of PT in identifying quality issues, analyzes the root causes of these problems, and proposes solutions for enhancing product quality. The PT scheme design includes securing ply boards conforming to IS 303:1989, ensuring the homogeneity and stability of samples, and employing robust statistical analyses. The results from eight participating laboratories for the Modulus of Rupture (MoR) and Modulus of Elasticity (MoE) were statistically evaluated, revealing some concerns regarding the performance of the material. The study concludes that PT is an essential tool for maintaining high-quality standards in the plywood industry, providing insights into laboratory performance, and highlighting areas for improvement. Recommendations for process modifications and quality control measures were provided, emphasising the importance of material selection, adhesive application, pressing parameters, and layer alignment. This study also underscores the need for in-process inspections, random sampling, end-of-line testing, traceability, employee training, quality awareness campaigns, cross-functional collaboration, and supplier audits to maintain consistent product quality and reliability.
Effectiveness of Calcium Supplementation for Improved Outcomes in Hypertensive Pregnancies in Developing Countries: A Systematic Review and Meta-Analysis
Authors: Ahiafe Saviour Selase , Gmanyami Jonthan Mawutor , Asiwome Ameko , Amuna Paul 
Published: October 2024

Abstract

Background: Hypertensive disorders of pregnancy are common and result in a substantial health burden. Evidence from epidemiological studies have shown an inverse relationship between calcium intake and development of hypertension in pregnancy. This study evaluated the evidence of effectiveness of calcium supplementation for improved outcomes in hypertensive pregnancies in developing countries.
Method: A systematic review was undertaken. Medline, Scopus, Hinari, and Cochrane databases were searched for literature published between 1985 to October 2020. Only RCTs published in English were included. Primary outcomes were pre-eclampsia, eclampsia and gestational hypertension. Secondary outcomes were preterm birth and low birth weight. Data were extracted from 21 selected RCTs for analysis. Meta-analysis was performed where data were available from more than one study for an outcome. Log risk ratio and the 95% confidence interval were estimated for each study. Risk ratios were directly pooled across studies using fixed-effects model if heterogeneity was absent, otherwise a random-effects model was used. P<0.05 was considered statistically significant, except for the test of heterogeneity where P<0.10 was used.
Results: Pooled analysis showed that calcium supplementation significantly reduced the risk of pre-eclampsia and gestational hypertension by 49% [RR: 0.51, (95% CI: 0.38, 0.67), P<0.001] and 53% [RR: 0.47, (95% CI: 0.32, 0.69), P<0.001] respectively when compared with placebo. The best intervention for lowering risk of pre-eclampsia and gestational hypertension was calcium supplement plus other co-supplements. The incidence of preterm delivery was lowered by 48% [RR: 0.52, (95% CI: 0.35, 0.78), P=0.001] in the intervention group.
Conclusion: There is strong evidence that maternal calcium supplementation is associated with improved outcomes in hypertensive pregnancies in developing countries.
Identifying the interactome of altered ion channels with lipid metabolism in SARS-CoV-2 infected patients in post-COVID-19 era
Authors: George John Philip , Parthasarathi K. T. Shreya , Gaikwad Kiran Bharat , Rana Shweta , Gupta Vibha , Kaur Punit , Pandey Akhilesh , Singh Harpreet , Sharma Jyoti 
Published: October 2024

Abstract

The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection continues to expand its horizon through the development of diverse symptoms, particularly concerning long COVID. The patients infected with the SARS-CoV-2 are being reported to develop new symptoms such as brain fog, fatigue, and other symptoms that are not limited to the respiratory system. The SARS-CoV-2 utilizes the human ion channels (HICs) and molecules involved in lipid metabolism from their entry to their egress. Here, to identify molecular alterations in HICs and lipid metabolism-related genes, transcriptomic data of 277 SARS-CoV-2 infected patients were analyzed. 287 HICs and 754 lipid metabolism-related genes were found to be differentially expressed in SARS-CoV-2 infected patients. Further, an interactome of altered HICs and lipid metabolism-related proteins with SARS-CoV-2 proteins was generated. Extensive data mining approach was employed to generate a pathway map highlighting alteration in several pathways including calcium signaling, long-term depression, and cholesterol metabolism in SARS-CoV-2 infected patients. Moreover, 17 potential drugs with known modes of action that interact with 4 altered HICs including inositol 1,4,5-triphosphate (InsP3) receptors and gap junction protein alpha 1 were identified. Most likely, these HICs are potential candidates for drug repurposing in patients infected with SARS-CoV-2 and require further experimental validation.
A pathway to protect 30% of coastal waters by 2030
Authors: Rechberger Kristin , Mayorga Juan , Booth Mara , Sala Enric 
Published: October 2024

Abstract

The countries of the world agreed to protect at least 30% of the global ocean by 2030 (30x30), from the current 8% under some kind of protection. However, there is no roadmap for achieving this global target. We find that, to achieve the protection of 30% of the exclusive economic zones of countries (EEZs), the world needs to establish 190,000 new small MPAs in territorial seas alone by 2030. Despite the proven benefits of coastal MPAs to nature and people, MPAs aren’t being established at the pace required to achieve the global target. We argue that the three main obstacles to scaling coastal MPAs are lack of awareness, inadequate governance, and the wrong business models. Here we propose a novel cost-effective and scalable pathway that would enable and equip coastal communities around the world to establish and effectively manage their own local MPAs.
Differential association of inflammation with pain and physical function in knee osteoarthritis by race: Focusing on non-Hispanic Whites and Asian Americans
Authors: Lee Chiyoung , Kwoh Kent , Park Juyoung , Ahn Hyochol 
Published: October 2024

Abstract

Background: The current body of work has not yet addressed the potential racial differences in the relationship between systemic inflammation and knee osteoarthritis (OA) symptoms, including pain and physical function. This pilot study aimed to investigate this association specifically among non-Hispanic Whites (NHWs) and Asian Americans.
Design: We cross-sectionally analyzed 40 community-dwelling participants aged 50–70 years with self-reported knee OA pain, including 20 NHWs and 20 Asian Americans. Knee OA symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and functional subscales. The serum levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-10, as systemic inflammatory markers, were measured. Univariate and multivariable analyses, using stepwise linear regression models, were conducted to examine the correlation between these inflammatory markers and OA symptoms, with systematic adjustment for age.
Results: In NHWs, the above inflammatory markers did not correlate with knee pain or physical function. In Asian Americans, bivariate analyses revealed that CRP and TNF-α were associated with worse WOMAC pain scores (r = 1.325, p = .041; r = 2.418, p= .036, respectively), and CRP was also linked to worse WOMAC functional scores (r = 4.950, p = .035). Multivariate analyses confirmed the association of CRP with both worse WOMAC pain (β = 1.328, p = .046) and functional (β = 4.974, p = .034) scores in this group.
Conclusions: CRP may be a clinically relevant marker for knee OA symptoms, specifically in Asian Americans; however, caution is warranted owing to the exploratory nature of this study. Future research is set to benefit from leveraging a larger sample, incorporating additional inflammatory markers, and including racially diverse samples to validate and augment these findings.
«Еврейский вопрос» в зеркале античной философии
Authors: Столяров А.А 
Published: October 2024

Данная статья посвящена «еврейскому вопросу» - насколько он может быть проиллюстрирован текстами античных философов и близких к ним авторов, - и основана на собраниях текстов Т. Рейнаха и М. Штерна. Как полагает автор статьи, антисемитизма как целенаправленной политики в античности не было. Если сопоставить позицию античного философского и околофилософского социума с отношением к евреям и иудаизму прочих античных интеллектуалов, то она в позитивном своем аспекте отличается более высоким уровнем рефлексии и, в частности, стремлением находить в иудаизме и монотеистической парадигме продуктивные элементы. Такой позиции придерживались многие представители платонической и пифагорейской традиции, особенно Нумений из Апамеи. Данную позицию, по мнению автора, можно считать в историко-философском плане гораздо более внимательной, а в историко-культурном - принципиально толерантной.
This article provides the vision of the “jewish question” in so far as the latter can be illustrated by the opinions of ancient philosophers and authors with semi-philosophical interests. The article rests upon the collections of texts supplied by T.Reinach and M.Stern, the starting point being one of the first works of S.Luria, the prominent Russian researcher of antiquity. Up to my mind, there existed no consistent and centralized antisemitic policy in antiquity. Far from being homogenous, the attitude of ancient philosophical and semi-philosophical socium towards jews and Judaism compared with that of other ancient intellectuals appears, however, to be marked in its positive aspect by a higher level of reflexion and by intention to find out productive elements in judaism and in monotheistic paradigm. Such attitude is peculiar to many adherents of platonic and pythagoreic tradition, particularly to Numenius; from the historic-philosophical and from historic-cultural points of view it appears to be more perceptive and decidedly tolerant.
«Участное мышление». Философский проект М.М.Бахтина в контексте онтологического поворота ХХ в
Authors: Махлин В.Л 
Published: October 2024

В статье анализируется научно-философский проект молодого М.М. Бахтина Невельско-Витебского периода его жизни и творчества (1918-1924) в двух взаимосвязанных направлениях: (1) «изнутри» его замысла «первой философии», на путеводной нити понятия «участное мышление»; и (2) «извне» этого замысла, в контексте магистрального события в западноевропейской философии конца 1910-1920-х гг., а именно - экзистенциально-онтологического поворота, связанного в особенности с понятием «социальная онтология» (Гуссерль, Шелер, Бубер, Г. Марсель, Сартр и др.). По мысли автора статьи, для того чтобы ответить на вопрос «Откуда взялся Бахтин?», недостаточно изолированных сопоставлений в расхожем жанре «Бахтин и…»; более перспективным представляется реализованный в статье историко-систематический подход, в соответствии с которым ключевые понятия проекта Бахтина - «конкретная историчность», «участное мышление», «событие бытия» и др. - применяются для осмысления того, почему и каким образом его проект одним из первых участвовал в общем поворотном событии мысли между Россией и Западом в тот исторический момент, когда это «между» еще не было разорвано. Кроме того, в статье показано, какие мотивы бахтинского философского проекта получили развитие в последующих, более известных работах М.М. Бахтина, включая так называемые «спорные тексты».
In this essay the young Bakhtin’s philosophical project from the early 1920s, is analyzed in two interrelated directions: first, within the “inner” context of his “first philosophy”, secondly, against the “outer” background of the West European (mostly German) turn to the “New Thinking”, that is, to the so-called existential ontology, or the “social ontology” (Husserl, Scheler. Buber, G. Marcel, Sartre et al.). Methodologically, in order to answer the question “Where did Bakhtin come from?”, the author of the essay, in contrast to the trend of research in the comparative genre of ‘Bakhtin and…’, works both historically and systematically using the ontological category of the “in-between”: his subject is just the “event of being” and the “concrete historicity” as mediation between Bakhtin’s project and the projects of his Western contemporaries. Thus, it becomes clear why and under what circumstances the Russian thinker’s concept of the “participative thinking” in fact participated in the European turn to the modern, or existential, ontology. Besides, some motives or elements in Bakhtin’s early project are taken into consideration, which he later developed in his well-known works written since the mid-1920s and up to the mid-1970s.
О подходах к пониманию истории в философии Б. Кроче и Э. Бетти
Authors: Россиус Ю.Г. 
Published: October 2024

Цель настоящей статьи сопоставить философские взгляды Б. Кроче и Э. Бетти применительно к их трактовке истории. Принимая во внимание существенное различие в исходных теоретических установках этих философов (неогегельянство и абсолютный историцизм Кроче и методологическую герменевтику Бетти), автор выбирает для соотнесения некоторые идеи, высказывания философов и фрагменты их работ, где просматривается сходство их позиций или же, напротив, моменты разногласий или положения, за которые философы критиковали друг друга. Как показано в статье, теория интерпретации истории у Бетти не испытала влияния со стороны крочеанского историцизма. Рассматривая концепцию современности истории у Кроче и ее схожесть с каноном актуальности понимания у Бетти, автор статьи отмечает, что Бетти пришел к этому тезису независимо от Кроче, в результате своих исследований в области истории права, и первоначально этот канон имел более узкую историко-правовую формулировку.
This paper aims to compare the interpretations of history put forward by Benedetto Croce and Emilio Betti. In view of the serious differences between the theoretical foundations of their respective positions (Croces neohegelianism and absolute historicism, on the one hand, and methodological hermeneutics in the case of Betti), the present author has chosen for comparison some of the opinions expressed and statements made by either philosopher, as well as such fragments of their works, where their views seem to converge, or, on the contrary, where the divergences are manifested with greatest clarity, in particular in the passages containing reciprocal criticism. The author comes to the conclusion that, contrary to the widespread belief, Bettis theory of the interpretation of history had not been influenced by the historicism of Croce to any considerable degree. Analyzing, among other things, the idea of modernity of history in Croce with its similarity to Bettis canon of actuality of the understanding, she demonstrates that Betti arrived at the same thesis independently of Croce as a result of his own investigations in the history of law, giving it initially a more restricted juridical formulation.