bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feline glioma: a retrospective study and review of the literature
Authors: Rissi Daniel R , Miller Andrew D 
Published: February 2017

Case series summary This study aimed to evaluate the pathologic and diagnostic features of 13 cases of feline glioma diagnosed at two veterinary diagnostic institutions over 16 years. A retrospective search was conducted using the laboratory information system. Selected cases were reviewed, tumors were classified according to the 2007 World Health Organization Classification of Tumours of the Central Nervous System, and tissue sections were submitted to an immunohistochemistry panel for further characterization. Affected cats were adults (average age 8 years), and male neutered (9/13) domestic shorthair cats (12/13) were over-represented. Clinical signs had acute onset and were progressive, lasting from 1–60 days (average course 20.7 days). Euthanasia was elected in all but one case, owing to a poor prognosis or because of a suspicion of rabies. Tumors occurred in the telencephalon (8/13), spinal cord (3/13) and brainstem (2/13). Gross changes in seven cases consisted of well- or poorly demarcated, gray-to-brown, soft, gelatinous masses that often caused secondary changes to the brain. The final diagnosis and classification were made based on histopathology and immunohistochemistry. Diagnoses consisted of oligodendroglioma (six cases), anaplastic astrocytoma (two cases), oligoastrocytoma, anaplastic ependymoma, gliomatosis cerebri, glioblastoma and anaplastic oligodendroglioma (one case each). Relevance and novel information This article confirms the need for a full neurologic and neuropathologic examination in cats with clinical neurologic disease. In addition, it highlights and proposes a complete routine immunohistochemical panel for diagnostic confirmation and differentiation between glioma and other morphologically similar central nervous system neoplasms in cats.
Age Related Multiple Sclerosis Severity Score: Disability ranked by age
Authors: Manouchehrinia Ali , Westerlind Helga , Kingwell Elaine , Zhu Feng , Carruthers Robert , Ramanujam Ryan , Ban Maria , Glaser Anna , Sawcer Stephen , Tremlett Helen , Hillert Jan 
Published: February 2017

Background: The Multiple Sclerosis Severity Score (MSSS) is obtained by normalising the Expanded Disability Status Scale (EDSS) score for disease duration and has been a valuable tool in cross-sectional studies. Objective: To assess whether use of age rather than the inherently ambiguous disease duration was a feasible approach. Method: We pooled disability data from three population-based cohorts and developed an Age Related Multiple Sclerosis Severity (ARMSS) score by ranking EDSS scores based on the patient’s age at the time of assessment. We established the power to detect a difference between groups afforded by the ARMSS score and assessed its relative consistency over time. Results: The study population included 26058 patients from Sweden ( n = 11846), Canada ( n = 6179) and the United Kingdom ( n = 8033). There was a moderate correlation between EDSS and disease duration ( r = 0.46, 95% confidence interval (CI): 0.45–0.47) and between EDSS and age ( r = 0.44, 95% CI: 0.43–0.45). The ARMSS scores showed comparable power to detect disability differences between groups to the updated and original MSSS. Conclusion: Since age is typically unbiased and readily obtained, and the ARMSS and MSSS were comparable, the ARMSS may provide a more versatile tool and could minimise study biases and loss of statistical power caused by inaccurate or missing onset dates.
Oral contraceptives and MS disease activity in a contemporary real-world cohort
Authors: Bove Riley , Rankin Kelsey , Chua Alicia S , Saraceno Taylor , Sattarnezhad Neda , Greeke Emily , Stuart Fiona , LaRussa Allison , Glanz Bonnie I , Chitnis Tanuja 
Published: February 2017

Background: There is uncertainty regarding the effect of oral hormonal contraceptives (OC) on multiple sclerosis (MS) course. Objective: To evaluate the hypothesis that OC use is associated with decreased risk of relapses in an observational study of women of childbearing age with new-onset MS starting a first-line injectable disease-modifying therapy (DMT). Methods: From our CLIMB longitudinal observational study, we identified 162 women with MS or CIS with known OC use who initiated injectable DMT within two years of symptom onset, and categorized OC use at DMT onset as past, ever or never. Our primary analysis was comparison of annualized relapse rate from baseline DMT start across the three OC use categories using a negative binomial regression model. Results: In this cohort of 162 women, 81 were treated with interferon therapy and 81 with glatiramer acetate. Mean ages for current-, past-, and never-OC users were 31.4 ( n = 46), 40.3 ( n = 66), and 37.9 ( n = 50) years, respectively ( p < 0.05); mean disease duration (1.0 years) and median baseline EDSS (1.0) did not differ between groups. Prior OC users had significantly lower relapse rates than never-users ( p = 0.031); the lower annualized relapse rate in current-users relative to never-users was not significant ( p = 0.91). Annualized relapse rate was not significantly different across the OC groups ( p = 0.057, three-group comparison). Results: These observations provide reassurance for women newly diagnosed that OC use, past or current, does not appear to be associated with greater risk of relapses.
Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions
Authors: Gao Bu-Lang , Wang Yong-Li , Zhang Xue-Jing , Fan Qiong-Ying , Hao Wei-Li , Zhang Dong-Hai 
Published: February 2017

Objective The aim of this study was to construct an in vivo carotid siphon model for testing neurovascular devices for endovascular interventions. Methods A model of a human carotid siphon was pre-shaped using a glass tube from a human cadaver and used to confine a segment of one side of the common carotid artery (CCA) in canines. This segment of CCA with the glass carotid siphon on was interposed end-to-end onto the contralateral CCA so as to simulate a human carotid artery siphon in vivo. Two weeks later, the siphon model was evaluated using computed tomography angiography and digital subtraction angiography, and the covered stent specially designed for intracranial vasculature was navigated through the siphon model for a longitudinal flexibility test. Results All dogs tolerated the procedures well, and the artificial siphon model in vivo provided realistic conditions for device testing. Two weeks later, the in vivo carotid siphon model remained patent with no thrombosis. Five covered stents were navigated to pass through five siphon models successfully, with vasospasm occurring in two siphons. Conclusion Construction of an in vivo siphon model in dogs with a glass tube is feasible and useful for the test of endovascular devices for treating neurovascular diseases.
Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson’s disease
Authors: Wang Chen-Tao , Mao Cheng-Jie , Zhang Xiao-Qi , Zhang Cai-Yi , Lv Dong-Jun , Yang Ya-Ping , Xia Kai-Lin , Liu Jun-Yi , Wang Fen , Hu Li-Fang , Xu Guang-Yin , Liu Chun-Feng 
Published: February 2017

Background Although pain is one of the most distressing non-motor symptoms among patients with Parkinson’s disease, the underlying mechanisms of pain in Parkinson’s disease remain elusive. The aim of the present study was to investigate the role of serotonin (5-hydroxytryptamine) in the rostral ventromedial medulla (RVM) and spinal cord in pain sensory abnormalities in a 6-hydroxydopamine-treated rat model of Parkinson’s disease. Methods The rotarod test was used to evaluate motor function. The radiant heat test and von Frey test were conducted to evaluate thermal and mechanical pain thresholds, respectively. Immunofluorescence was used to examine 5-hydroxytryptamine neurons and fibers in the rostral ventromedial medulla and spinal cord. High-performance liquid chromatography was used to determine 5-hydroxytryptamine and 5-hydroxyindoleacetic acid levels. Results The duration of running time on the rotarod test was significantly reduced in 6-hydroxydopamine-treated rats. Nociceptive thresholds of both mechanical and heat pain were reduced compared to sham-treated rats. In addition to the degeneration of cell bodies and fibers in the substantia nigra pars compacta, the number of rostral ventromedial medulla 5-hydroxytryptamine neurons and 5-hydroxytryptamine fibers in the spinal dorsal horn was dramatically decreased. 5-Hydroxytryptamine concentrations in both the rostral ventromedial medulla and spinal cord were reduced. Furthermore, the administration of citalopram significantly attenuated pain hypersensitivity. Interestingly, Intra-rostral ventromedial medulla (intra-RVM) microinjection of 5,7-dihydroxytryptamine partially reversed pain hypersensitivity of 6-hydroxydopamine-treated rats. Conclusions These results suggest that the decreased 5-hydroxytryptamine contents in the rostral ventromedial medulla and spinal dorsal horn may be involved in hyperalgesia in the 6-hydroxydopamine-induced rat model of Parkinson’s disease.
Invasive tracheal neoplasia in eight cats: descriptive cases and review of the current literature
Authors: Howard James , Fisher Jade , Tolbert M Katherine 
Published: February 2017

Case series summary This case series describes eight cases of invasive tracheal neoplasia that were recognized between the years 1989 and 2014 from a single tertiary referral hospital. This is a disproportionately high number of cases compared with the total number of reports in the current literature. Relevance and novel information Invasive tracheal neoplasia is uncommonly diagnosed in domestic cats. Feline tracheal tumors mimic other upper respiratory diseases making diagnosis challenging. Prognosis is guarded to grave, with most cats surviving less than 1 month after beginning treatment. Severe respiratory distress in cats often warrants humane euthanasia. Appropriate clinical suspicion and awareness can expedite diagnoses leading to prolonged survival rates with appropriate treatments. This case series represents the largest number of feline tracheal tumors reported and also describes the first unique histological presentation of what the authors believe to be a poorly differentiated tracheal carcinoma.
Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial
Authors: Ramsay Ian S. , Nienow Tasha M. , Marggraf Matthew P. , MacDonald Angus W. 
Published: February 2017

BackgroundPatients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.AimsTo use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).MethodTwenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.ResultsWe observed a group × time interaction in the left prefrontal cortex, wherein the cognitive remediation group showed increased activation. These changes correlated with improved task accuracy within the cognitive remediation group, whereas there was no relationship between changes in activation in untrained cognitive measures. Significant changes were not observed in other hypothesised areas for the cognitive remediation group.ConclusionsWe replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.
Psychological interventions for post-traumatic stress disorder and depression in young survivors of mass violence in low- and middle-income countries: Meta-analysis
Authors: Morina Nexhmedin , Malek Mina , Nickerson Angela , Bryant Richard A. 
Published: February 2017

BackgroundThe majority of survivors of mass violence live in low- and middle-income countries (LMICs).AimsTo synthesise empirical findings for psychological interventions for children and adolescents with post-traumatic stress disorder (PTSD) and/or depression in LMICs affected by mass violence.MethodRandomised controlled trials with children and adolescents with symptoms of PTSD and/or depression in LMICs were identified. Overall, 21812 records were found through July 2016 in the Medline, PsycINFO and PILOTS databases; 21 met the inclusion criteria and were reviewed according to recommended guidelines.ResultsTwenty-one studies were included. Active treatments for PTSD yielded large pre-treatment to post-treatment changes (g= 1.15) and a medium controlled effect size (g= 0.57). Effect sizes were similar at follow-up. Active treatments for depression produced small to medium effect sizes. Finally, after adjustment for publication bias, the imputed uncontrolled and controlled effect sizes for PTSD were medium and small respectively.ConclusionsPsychological interventions may be effective in treating paediatric PTSD in LMICs. It appears that more targeted approaches are needed for depressive responses.
A feasibility randomised controlled trial of the DECIDE intervention: Dementia carers making informed decisions
Authors: Lord Kathryn , Livingston Gill , Cooper Claudia 
Published: February 2017

SummaryFamily carers report high levels of decisional conflict when deciding whether their relative with dementia can continue to be cared for in their own home. We tested, in a feasibility randomised controlled trial, the first decision aid (the DECIDE manual) aiming to reduce such conflict. Twenty family carers received the DECIDE intervention, and 21 received usual treatment. The intervention group had reduced decisional conflict compared with controls (mean difference −11.96, 95% confidence interval −20.10 to −3.83, P=0.005). All carers receiving the intervention completed and valued it, despite some still reporting difficulties with family conflict and problems negotiating services.
Struktur komunitas mangrove di Pulau Mare, Kota Tidore Kepulauan, Provinsi Maluku Utara (Community structure of mangrove in Mare Island, Tidore City, Maluka Utara Province
Authors: Akbar Nebuchadnezzar , Baksir Abdurrachman , Tahir Irmalita , Arafat Dondy 
Published: February 2017

This study aimed to obtain information mangrove ecological index in Mare Island, Tidore Kepulauan, North Maluku. Collecting data in 2015, divided into three locations were determined based representation and the representation of mangrove. The sampling of mangrove using "line transect quadrant". The results obtained by mangrove thickness between 85-150 meters with 5 types of 3 families mangrove. Rhizophora mangrove species are found most dominating every station. Mangrove ecological index categories density, frequency, cover and species diversity is highest at the station I. While important value criteria at each station are 300. Analysis of vegetation mangrove species at each station obtained density, frequency, species diversity and the importance of the highest species is Rhizophora apicullata, then cover the highest species is Sonneratia alba. Overall results of observation and analysis, illustrating that the condition of mangroves on the island of Mare in the category of low/sparse.Penelitian ini bertujuan untuk memperoleh informasi indeks ekologi mangrove di Pulau Mare, Tidore Kepulauan, Maluku Utara. Pengambilan data pada tahun 2015 yang terbagi atas tiga lokasi yang ditetapkan berdasarkan keterwakilan dan reprsentasi mangrove. Pengambilan contoh mangrove, di lakukan dengan menggunakan metode “line transect quadrant”. Hasil penelitian diperoleh ketebalan mangrove diantara 85-150 meter dengan 5 jenis dari 3 famili mangrove. Jenis mangrove Rhizophora ditemukan paling mendominasi disetiap stasiun. Indeks ekologi mangrove kategori kerapatan, frekuensi, tutupan dan keanekaragaman jenis paling tinggi terdapat di stasiun satu. Sedangkan kriteria nilai penting pada setiap stasiun adalah 300. Analisis vegetasi jenis mangrove pada setiap stasiun diperoleh kerapatan, frekuensi, keanekaragaman jenis dan nilai penting jenis tertinggi adalah Rhizophora apicullata, kemudian tutupan jenis tertinggi adalah Sonneratia alba. Keseluruhan hasil pengamatan dan analisis, menggambarkan bahwa kondisi mangrove di pulau Mare masuk dalam kategori rendah.
Evaluation of Hypoplastic Clay Model for Deep Excavation Modelling
Authors: Mitew-Czajewska M. 
Published: February 2017

AbstractThis paper presents an evaluation of the Hypoplastic Clay constitutive model for finite element analysis of deep excavations and displacements induced by excavations in the influence zone. A detailed description and formulation of the Hypoplastic Clay soil model is included. A parametric case study of a deep excavation executed in Pliocene clays is presented. FE analysis was performed using several soil models (Mohr-Coulomb, Modified Mohr-Coulomb, Drucker-Prager, Modified Cam-Clay, Hypoplastic Clay) and the results were compared to in-situ displacements measurements taken during construction. Final conclusions concerning the suitability of the Hypoplastic Clay model for deep excavation modelling in terms of accurate determination of horizontal displacements of the excavation wall, the uplift of the bottom of excavation, and, most importantly, vertical displacements of the terrain in the vicinity of the excavation are presented.
The Market Value of R&D in Emerging Economies: Evidence from India
Authors: Kanwar Sunil , Hall Bronwyn H. 
Published: February 2017

Abstract
We revisit the relationship between market value and innovation in the context of manufacturing firms in a developing country, using data for Indian firms from 2001 through 2010. Surprisingly, we find that financial markets value the R&D investment of Indian firms the same or higher than it values such investment in developed economies such as the United States and European countries, suggesting some degree of underinvestment. The paper explores the use of a proxy for the option value of R&D and finds that this can account for a very small part of the R&D valuation (about 10 %). We also find that the market value–R&D relationship does not vary significantly across industry groups, although these results are rather imprecise.
Variant peptide detection utilizing mass spectrometry: laying the foundations for proteogenomic identification and validation
Authors: Dimitrakopoulos Lampros , Prassas Ioannis , Berns Els M.J.J. , Foekens John A. , Diamandis Eleftherios P. , Charames George S. 
Published: February 2017

AbstractBackground:Proteogenomics is an emerging field at the intersection of genomics and proteomics. Many variant peptides corresponding to single nucleotide variations (SNVs) are associated with specific diseases. The aim of this study was to demonstrate the feasibility of proteogenomic-based variant peptide detection in disease models and clinical specimens.Methods:We sought to detect p53 single amino acid variant (SAAV) peptides in breast cancer tumor samples that have been previously subjected to sequencing analysis. Initially, two cancer cell lines having a cellular tumor antigen p53 (TP53) mutation and one wild type for TP53 were analyzed by selected reaction monitoring (SRM) assays as controls. One pool of wild type and one pool of mutated for TP53 cytosolic extracts were assayed with a shotgun proteogenomic workflow. Furthermore, 18 individual samples having a mutation in TP53 were assayed by SRM.Results:Two mutant p53 peptides were successfully detected in two cancer cell lines as expected from their DNA sequence. Wild type p53 peptides were detected in both cytosolic pools, however, none of the mutant p53 peptides were identified. Mutations at the protein level were detected in two cytosolic extracts and whole tumor lysates from the same patients by SRM analysis. Six thousand and six hundred and twenty eight non-redundant proteins were identified in the two cytosolic pools, thus greatly improving a previously reported cytosolic proteome.Conclusions:In the current study we show the great potential of using proteogenomics for the direct identification of cancer-associated mutations in clinical samples and we discuss current limitations and future perspectives.
Game Performance and Length of Rally in Professional Padel Players
Authors: Courel-Ibáñez Javier , Sánchez-Alcaraz Martínez Bernardino Javier , Cañas Jerónimo 
Published: February 2017

AbstractThe purpose of this study was to analyse differences in rally length considering attack effectiveness, a players’ location and a game outcome in professional padel players. A total of 1527 rallies from 10 male matches of the 2013 Masters Finals of the World Padel Tour were registered through systematic observation. Data treatment included non-parametric mean comparisons (Mann-Withney and Kruskal-Wallis tests), and association analyses (crosstabs and Chi square analysis). In overall, 40% of unforced errors were made within the first 4 s of the rally, over 50% of points were scored between the 5th and 11th s, and 30% of forced errors occurred after the 11th –s of the rally. Hence, the ability to score in rallies of over 11 s duration and not making unforced errors within the first 4 s contributed to the rally outcome. More specifically, winners played longer rallies compared to losers (10.42 ± 7.77 s vs. 8.42 ± 6.43 s); particularly at the net, when scoring from the baseline (11.04 ± 7.64 s vs. 8.90 ± 5.41 s) and making forced (8.86 ± 7.44 s vs. 6.86 ± 6.24 s) and unforced errors (11.91 ± 9.47 s vs. 8.33 ± 6.92 s). Such knowledge may have implications in the design and structure of specific training programmes for padel players according to competition requirements.
Anger Management - Evaluation of a Cognitive-Behavioral Training Program for Table Tennis Players
Authors: Steffgen Georges 
Published: February 2017

AbstractBased on a systematic review of the literature on anger and anger management in sport, there is evidence that anger might be dysfunctional, especially in sports requiring selective attention and fine-tuned motor skills. The research literature suggests that cognitive-behavioral intervention programs can be fruitful in helping athletes to understand and control dysfunctional anger. Therefore, the main goal of the present study was to evaluate the effectiveness of a brief training program for table tennis players in cognitive-behavioral anger management that aimed at changing their noneffective anger reactions. The sample comprised 18 young competitive table tennis players (age range from 16 to 22 years) divided randomly into a treatment (n = 10) and a control group (n = 8). A trained group leader instructed the treatment group. Six sessions were held over a period of two months. Cognitive-relaxation coping skills associated with social skills of subjects from the treatment group were compared to no-treatment controls. Psychological measurements (i.e., self-reports on anger) were applied before, during and after treatment as well as in a follow-up session. The one-year follow-up session revealed that, in contrast to the control group, the treatment group showed a significant reduction in outwardly negative anger expression as well as anger reactions specific to table tennis. Despite limitations inherent in the research design, the training program was deemed effective.