bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Engagement in Collaborative Care Treatment of Uncontrolled Diabetes in a Safety-Net Clinic
Authors: Belyeu Brittaney , Chwastiak Lydia , Russo Joan , Kiefer Meghan , Mertens Kathy , Chew Lisa , Jackson Sara L. 
Published: October 2017

Purpose The purpose of the study was to evaluate patient factors associated with nonengagement in a Diabetes Collaborative Care Team (DCCT) program in a safety-net clinic. Methods The first 18 months of a multidisciplinary care, team-based diabetes care management program in a safety-net primary care clinic were studied. Nonengagement was defined as fewer than 2 visits with a team member during the 18 months of the program. Patients who did not engage in the program were compared with those who did engage on demographics, comorbid medical and psychiatric diagnoses, and cardiovascular risk factors, using univariate and multivariable analyses. Results Of the 151 patients referred to the DCCT, 68 (45%) were nonengaged. In unadjusted analyses, patients who did not engage were more likely to be female and have higher baseline A1C values; they were less likely to have major depressive disorder, anxiety disorder, any depression diagnosis, and hyperlipidemia. Female gender and chronic pain were independently associated with nonengagement after multivariable adjustment. Conclusions The findings suggest that among patients with uncontrolled diabetes in an urban safety-net primary care clinic, there is a need to address barriers to engagement for female patients and to integrate chronic pain management strategies within multicondition collaborative care models.
Role of Extra-articular Tibiotalocalcaneal Arthrodesis and Posterior Approach in Highly Complex Cases
Authors: Eckholt Sergio , Garcia-Elvira Ruben , Fontecilla Nicolás , Fernandez-Reinales Alvaro , Poggio Daniel 
Published: October 2017

Background: Tibiotalocalcaneal (TTC) arthrodesis is a procedure commonly used as salvage surgery for various pathologic processes that compromise the ankle and subtalar joints. It is a reasonably standardized procedure when performed as a primary surgery in advanced stages of TTC arthritis. For such cases, there are several alternative approaches, fixation materials, and bone substitutes that can be used. Most represent valid options with similar results in the literature. However, in highly complex cases requiring TTC arthrodesis, the options for the approach and fixation material can be limited. Understanding the alternative approaches and techniques is of great help to the surgeon when faced with highly complex cases, such as patients with multiple previous operations, lack of bone stock, severe deformities, or compromise of associated soft tissues. In this article, we describe the role of the posterior approach with some technical variation that allows extra-articular arthrodesis in highly complex cases, and we present a series of patients with tibiotalocalcaneal arthrodesis who were operated on using this technique. Methods: Retrospective review of all patients who underwent tibiotalocalcaneal arthrodesis via posterior approach between 2008 and 2016. The surgeries were performed by 2 different surgeons with the same technique (posterior approach with sliding graft) but 2 different fixation methods. Radiographs and computed tomographic (CT) studies were reviewed and patient satisfaction was rated using the Coughlin scale. Mean follow-up was 38 months. We identified 20 patients. The mean age was 51.2 years; 11 patients had post-traumatic arthritis whereas the others had other causes of arthritis (inflammatory disease, neurologic deformity, etc). Results: The arthrodesis was performed using a tibiotalocalcaneal plate in 9 patients and retrograde intramedullary nail in 11 patients. Radiographic fusion was observed at an average of 3.1 months. Four patients had complications and 15 reported good or excellent results after surgery. Conclusion: Our study found a fusion rate comparable to other studies in highly complex cases. There were no operative wound complications. We observed that the posterior approach, with an extra-articular fusion procedure, was a valid option for salvage surgery in highly complex cases that require tibiotalocalcaneal fusion. Level of Evidence: Level IV, retrospective case series.
Subcutaneous metastasis from recurrent basaloid squamous cell carcinoma of the esophagus
Authors: Puri Sonam , Holle Lisa M , Forouhar Faripour A , Clement Jessica M 
Published: October 2017

Background Esophageal cancer is the 11th most common cause of cancer mortality in the United States. It is aggressive in nature and has an ability to spread rapidly through direct extension, lymphatic spread, or hematogenously. With an estimated incidence of 1%, cutaneous metastases from esophageal cancer are extremely rare. Case presentation In this case study and review, we describe a case of recurrent esophageal basaloid squamous cell carcinoma presenting as multiple, rapidly progressing and tender subcutaneous nodules. A 69-year-old male with history of basaloid squamous cell carcinoma of the esophagus treated with concurrent chemoradiation, presented to his oncologist with complaints of a large, painful nodule at the nape of his neck approximately two years after completing treatment. On further examination, he was noted to have multiple, well circumscribed, solid, tender nodules on his abdominal wall along with a painful nodule on the pulp of his index finger. Histopathology from all sites revealed skin infiltration by high-grade invasive basaloid subtype of squamous cell carcinoma, similar to patient’s prior known and treated primary esophageal cancer. Further imaging work up showed extensive metastatic disease involving lung, liver, and brain. Conclusion Esophageal squamous cell carcinoma rarely metastasize to the skin. Subcutaneous nodules can be the first presentation of recurrent disease. The lesions are commonly confused with skin infections and treated inappropriately with antibiotics, leading to delay in diagnosis of recurrent disease. Early biopsy of suspicious lesions should be performed, especially in patients with history of cancer, such that prompt diagnosis and treatment can occur to maximize patient outcomes.
A clinical pharmacy pilot within a Precision Medicine Program for cancer patients and review of related pharmacist clinical practice
Authors: Arnall Justin R , Petro Robin , Patel Jai N , Kennedy LeAnne 
Published: October 2017

Purpose The implementation, benefits, and challenges of clinical pharmacist services within a Precision Medicine Program for cancer patients are described. By relating the practice model that was developed, this report may further encourage pharmacists at cancer centers nationally to be involved and lead precision-based care in the oncology setting. Summary A clinical pharmacist was integrated into a Precision Medicine Program for oncology patients using somatic testing to identify actionable mutations and apply targeted therapy to malignancies. This pharmacist served as a drug resource for the program’s molecular tumor board and oncologists seeking precision-based oncologic strategies. The pharmacist was a facilitator of drug assistance and dispensing in collaboration with the specialty pharmacy and provided care to 14 oncology patients receiving precision-based therapies. The clinical pharmacist was readily accepted as an addition to the team by both oncologists and patients and the experience served as an important learning opportunity. Conclusion The success of integrating this precision medicine pharmacist into a newly formed Precision Medicine Program and the model it can serve as may be considered for other cancer centers that may or may not have easily accessible pharmacogenomic experts and resources. This service highlights the importance of pharmacist care in such a program and the various opportunities for integration. Oncology clinical pharmacists should seek to integrate into Precision Medicine Programs and systems directing this care and develop their knowledge and understanding of genomics to continue providing the highest level of cancer care as a pivotal member of the cancer care team.
A Treatment Algorithm for Moderate to Severe Atopic Dermatitis in Adults
Authors: Lynde Charles W. , Bourcier Marc , Gooderham Melinda , Guenther Lyn , Hong Chih-ho , Papp Kim A. , Poulin Yves , Sussman Gordon , Vender Ronald 
Published: October 2017

Background: Atopic dermatitis (AD) is a common and chronic inflammatory skin disease. Approximately 10% of adults with AD do not respond adequately to topical therapies and require phototherapy and/or systemic therapy. Objective: To provide a patient-focused approach to the identification and management of adults with AD who require systemic treatment. Methods: A working group of clinicians experienced in managing AD was convened to review and discuss current evidence on the identification and clinical management of adults with moderate to severe AD. Results: We propose a set of simple and practical clinical criteria for selecting candidates for systemic treatment of AD based on their response to first-line topical therapy and 4 clinical measures that are easily incorporated into routine practice. We also suggest a framework for evaluating systemic treatments according to attributes that are important from both a clinician’s and a patient’s perspective. An algorithm was developed proposing a pathway for treatment of moderate to severe AD in adults. Conclusion: Adults with moderate to severe AD that does not respond adequately to topical therapies currently have few safe and effective treatment options. A clinical algorithm could help guide treatment decisions.
The use of telemedicine for delivering healthcare in Japan: Systematic review of literature published in Japanese and English languages
Authors: Ito Jun , Edirippulige Sisira , Aono Takeshi , Armfield Nigel R 
Published: October 2017

Background In common with other countries, Japan has an ageing population and geographical impediments to healthcare access. The role of telemedicine within the Japanese health system may be of wide interest, yet it has not been comprehensively explored and documented. Thus, the aim of this study was to systematically review the Japanese and English language literature relating to the clinical use of telemedicine in Japan. Methods For studies published in Japanese, we searched Ichushi and CiNii. For English language publications, we searched Cochrane Library, PubMed, Embase, and Web of Science. All peer-reviewed articles describing the clinical use of telemedicine and published between 2007 and 2016 were included. Data on clinical area, study type, technology used, and type of communication were extracted. Studies were categorised by prevention, screening, diagnosis, surveillance, and treatment. Results The search yielded 1476 records; 26 Japanese language and 15 English language articles were selected for review. A wide range of clinical areas were represented; however, home care and life-style related studies were dominant. More than 50% of studies were related to prevention and early diagnosis. The majority of Japanese studies involved doctor-to-doctor consultation. Smartphones and remote monitoring systems were the main types of technology used. Conclusions Most studies of telemedicine in Japan are published in the Japanese language and are thus relatively inaccessible to the rest of the world; for the first time, this study has provided an overview of the clinical use of telemedicine in Japan. The clinically related papers reflect the Japanese cultural focus on disease prevention.
Immune regulation effect of lienal polypeptides extract in Lewis lung carcinoma-bearing mice treated with cyclophosphamide
Authors: Wu Yan-Ping , Deng Jie , Ouyang Shu-Hua , Mao Zhong-Fu , Wang Guo-En , Kurihara Hiroshi , He Rong-Rong , Li Yi-Fang 
Published: October 2017

Polypeptides extracted from animal immune organs have been proved to exert immunomodulatory activities in previous reports. However, relative experimental data regarding the influence of a polypeptide mixture extracted from healthy calf spleen (lienal polypeptide [LP]) on the immune function in tumor therapy are limited, and the components in LP remain unclear. In the present study, the immune regulatory effect of LP was investigated in normal mice and Lewis lung carcinoma (LLC)-bearing mice treated with cyclophosphamide (CTX). The components of LP were identified by liquid chromatography–electrospray ionization-coupled with tandem mass spectrometry (LC–MS/MS) analysis and bioinformatic analysis. In LLC-bearing mice, LP showed a synergic antitumor effect with CTX, whereas LP alone did not present direct antitumor activity. Further, LP was found to enhance immune organ indexes, splenocyte number, and T lymphocyte subsets in normal mice and LLC-bearing mice treated with CTX. The decline of white blood cell and platelet counts, splenocyte proliferation activity, and peritoneal macrophage phagocytic function caused by CTX were also significantly suppressed by LP treatment in LLC-bearing mice. Notably, LP treatment significantly decreased the expression of phagocytosis-related proteins including CD47/signal regulatory protein α/Src homology phosphatase-1 in the tumor tissue of LLC-bearing mice treated with CTX. LC-MS/MS-based peptidomics unraveled the main polypeptides in LP with a length from 8 to 25 amino acids. Bioinformatics analysis further confirmed the possibility of LP to regulate immunity, especially in phagocytosis-related pathway. Our above findings indicated that LP can relieve the immunosuppression induced by chemotherapy and is a beneficial supplement in cancer therapy.Impact statementThe immunomodulatory activities of polypeptides extracted from animal immune organs have incurred people’s interests since a long time ago. In this study, we investigated the immune regulation effects of a polypeptide mixture extracted from health calf spleen (lienal polypeptide [LP]) in Lewis lung carcinoma-bearing mice treated with cyclophosphamide (CTX). Liquid chromatography–electrospray ionization-coupled with tandem mass spectrometry-based peptidomics and bioinformatics analysis unraveled the main polypeptides in LP and further confirmed that LP is mainly associated with immune regulating pathway, especially in tumor cell phagocytosis-related pathway. Our study for the first time revealed that polypeptides from spleen can relieve the immunosuppression induced by CTX and is a beneficial supplement in cancer therapy.
Redefining the role of etoposide in first-line treatment of peripheral T-cell lymphoma
Authors: Kim Young Ae , Byun Ja Min , Park Keeho , Bae Gi Hwan , Lee Dukhyoung , Kim Dong Sook , Yoon Sung-Soo , Koh Youngil 
Published: October 2017

Key Points
Etoposide addition/chemo-intensification has little role in first-line treatment of PTCL in Asian populations, regardless of subtype or age. Upfront hematopoietic stem-cell transplantation as consolidation seems like a legitimate choice in patients with PTCL.
Synthesis of Anion-Mixed Crystals of Assembled Complexes Bridged by 1,2-Bis(4-pyridyl)ethane and the Ligand Field of Fe(NCS)(NCBH3) Unit
Authors: Dote Haruka , Kaneko Masashi , Inoue Katsuya , Nakashima Satoru 
Published: October 2017

Abstract
Anion-mixed iron(II) assembled complexes using NCS and NCBH3 as anionic ligand and bridged by 1,2-bis(4-pyridyl)ethane (bpe) are synthesized under several conditions for various ratios of NCS to NCBH3. Elemental analysis showed that the experimentally observed fractions of NCS tend to be more than those in the preparation. Some structures are determined by using single crystal X-ray structural analysis. Powder X-ray diffraction patterns are compared among the anion-mixed crystals. 57Fe Mössbauer spectroscopy reveals that a new doublet appears and it is different from the doublets of Fe(NCS)2 and Fe(NCBH3)2 units and the relative area of this new doublet reaches maximum when the fraction of NCS is around 1.0 per each iron, suggesting that the new doublet is ascribed to an Fe(NCS)(NCBH3) unit. Corresponding anion-mixed complexes enclathrating p-dichlorobenzene (p-DCB) are synthesized. Superconducting quantum interference device (SQUID) measurement and Mössbauer spectroscopy reveal that the complexes show spin-crossover (SCO) phenomenon and the relative area of the low-spin state is more than the expected value. The existence of Fe(NCS)(NCBH3) is supported by the results of SQUID measurement and density functional theory (DFT) calculation. Ligand field splitting strength of Fe(NCS)(NCBH3) unit is estimated to be intermediate between Fe(NCS)2 and Fe(NCBH3)2 units. Complexes enclathrating p-DCB display propeller conformation of bpe around the iron atom, while complexes without a guest molecule have distorted propeller conformation of bpe around the iron atom. It is suggested that such difference determines whether the SCO is on or off.
Two Diastereomers of d-Limonene-Derived Cyclic Carbonates from d-Limonene Oxide and Carbon Dioxide with a Tetrabutylammonium Chloride Catalyst
Authors: Morikawa Hiroshi , Minamoto Masato , Gorou Yuuta , Yamaguchi Jun-ichi , Morinaga Hisatoyo , Motokucho Suguru 
Published: October 2017

Abstract
Two diastereomers of d-limonene-derived five-membered cyclic carbonates were prepared from the corresponding isomers of d-limonene oxide with CO2. Their syntheses were catalyzed by commercially available tetrabutylammonium chloride with high stereoselectivity. The reaction behavior dependent on the reaction conditions such as CO2 pressure was clarified.
Students’ scientific knowledge and skills as a prerequisite for studying health care at the tertiary level – the Tartu Health College case
Authors: Ploomipuu Inga , Holbrook Jack 
Published: October 2017

Tervishoiuvaldkonnas võib üliõpilaste puudulik ettevalmistus viia probleemideni kõrgkoolis (nt üliõpilaste väljalangemine) ning hiljem ka sotsiaalsfääris (nt kvalifitseeritud tööjõu puudus tervishoiusüsteemis). Probleemide ennetamiseks on oluline hinnata, kas ja mil määral esineb puudusi kõrgkooli sisseastujate ettevalmistuses loodusteaduste valdkonnas. Uurimuse eesmärk on välja selgitada kõrgkooli tervishoiu erialadele õppima asunud gümnaasiumilõpetajate loodusteaduslike teadmiste ja oskuste tase loodusteadusliku ning tervisealase kirjaoskuse aspektide kaudu. Valimisse kuulusid Tartu Tervishoiu Kõrgkooli esimese aasta üliõpilased (n = 213), kes täitsid kontekstipõhise interdistsiplinaarse küsimustiku. Uurimistulemustest selgub, et Tartu Tervishoiu Kõrgkooli sisseastunute loodusteaduslikud teadmised ja oskused on ebapiisavad ning see võib osutuda takistuseks edasistes õpingutes. Heal järjel on vaid madalamat järku oskused, nt aineteadmiste reprodutseerimine. Loodusteadusliku kirjaoskuse puhul pole piisavalt heal tasemel üliõpilaste kommunikatiivsed ja praktilised oskused (nagu probleemide lahendamine, otsuste tegemine ja nende loodusteaduslik põhjendamine), mis on paljuski edasiste õpingute eelduseks ja mis seetõttu vajavad rohkem arendamist. Kuigi oskuste taset mõjutavad varasem haridus, gümnaasiumiõpingutest möödunud aeg ja motivatsioon edasi õppida, saaks kõrgkool pakkuda puudujääkide korvamiseks kursusi, mille kaudu toetataks loodusteaduslikku kirjaoskust, sh enesetõhusust ja loodusteaduslike ainete õpimotivatsiooni.
Summary
Estonian science teachers’ pedagogical beliefs, teaching practices and self-efficacy based on the results of the TALIS 2008 and 2013 reports
Authors: Henno Imbi , Kollo Liina , Mikser Rain 
Published: October 2017

Artiklis käsitletakse TALIS 2013 uuringus osalenud loodusainete õpetajate uskumusi, õpetamispraktikat ja enesetõhususe hinnanguid ning võrreldakse tulemusi TALIS 2008 uuringu omadega. Analüüsist selgub, et võrreldes teiste ainete õpetajatega olid loodusainete õpetajate uskumused nii TALIS 2008 kui ka TALIS 2013 uuringus konstruktivistlikumad. Kui esimeses, TALIS 2008 uuringus ei erinenud eesti ja vene õppekeelega koolide loodusainete õpetajate uskumused ja enesetõhususe hinnangud statistiliselt olulisel määral, siis teises, TALIS 2013 uuringus olid eesti õppekeelega koolide õpetajate uskumused konstruktivistlikumad, kuid enesetõhususe hinnangud madalamad. Õpetamispraktika kohta selgus, et õpilaste motiveerimist ja aktiveerimist rakendavad loodusainete õpetajad samal määral kui teiste ainete õpetajad.
Summary
Remix, literacy and creativity: An analytic review of the research literature
Authors: Knobel Michele 
Published: October 2017

Loovust on hakatud pidama riikide majanduskasvu võtmeteguriks, mis tagab ühiskonnas toimetuleku ja mille abil tagatakse isiklik või ühiskondlik heaolu. Seda silmas pidades on mõistlik süveneda loovuse käsitusse ja praktilisse olemusse ning uurida nende seostamise võimalusi hariduse kontekstis. Olukord koolides on mahukate uurimistulemuste põhjal koolivälise tegelikkusega teravas vastuolus, sest vähe võetakse arvesse inimeste loomingulisust ja suurt kujutlusvõimet tähenduste loomisel, mille üks väljendusvorme on remiksimine. Artikli eesmärk on anda ülevaade olemasolevatest ingliskeelsetest uurimustest, milles käsitletakse digitaalset remiksimist ja kirjaoskust, ning selgitada välja mustrid, mis näitavad, kuidas tavalised inimesed on ennast loominguliselt väljendanud. Analüütilise ülevaate koostamisel uuriti viimase kahe kümnendi jooksul inglise keeles ilmunud empiirilisi publikatsioone ning koostati ülevaade avaldatud teadusartiklitest koolivälise remiksimise ja kirjaoskuse kohta. Uurimise käigus selgitati välja need loominguliste püüdluste ja tähenduste loomise viisid, millest koolipedagoogika saaks midagi kasulikku õppida. Ühtlasi vaadeldi, kuidas digitaalset remiksimist ja kirjaoskust on uuritud. Kõigis 36 analüüsitud uurimuses rõhutati, et lähenemine loovusele kui sügavalt sotsiaalsele nähtusele aitab vastu seista kasulikkust taga ajavatele lähenemisviisidele. Uurimustes vaatluse all olnud remiksitud tööd näitavad teadlikku loovuse arendamise püüdlust, mis võib aidata inimestel loominguliselt hakkama saada või reageerida kiiretele muutustele ning ühiskondlikele, riiklikele ja keskkondlikele probleemidele praegu ja tulevikus, luues ja säilitades samal ajal suhteid suurte vahemaade ja erinevuste kiuste.
Full text
The preschool teachers’ beliefs about children’s general skills according to the Estonian national curriculum: an added explanation to the causes of the “schoolification” of early childhood institutions
Authors: Neudorf Evelyn , Ugaste Aino , Tuul Maire , Mikser Rain 
Published: October 2017

Viimase aja rahvusvaheline tendents alushariduses on koolistumine ehk õppe- ja kasvatustegevuse suurem sarnanemine üldhariduskooliga. See avaldub eelkõige õppimise esmatähtsustamises ja laste arengu pidevas hindamises. Paljude uurijate hinnangul põhjustab seda ühiskondlik surve tagada laste koolivalmidus ja alusharidusasutuste konkurents eri huvirühmade ootuste täitmisel. Uurimuse eesmärk on välja selgitada lasteaiaõpetajate uskumused riikliku õppekava üldoskuste väärtuslikkuse ehk olulisuse kohta ning nende enesetõhususe hinnangud asjaomaste tegevuste leidmisele ja üldoskuste hindamisele. Ankeedis hindas 729 Eesti lasteaiaõpetajat koolieelse lasteasutuse riiklikus õppekavas (2008) esitatud üldoskuste olulisust ning nende omandamiseks vajalike tegevuste leidmise ja üldoskuste hindamise lihtsust. Uurimistulemustest selgub, et mänguoskusi kui senist alushariduse prioriteeti peetakse olulisimaks, ent tegevuste leidmisel ja hindamisel on lihtsam keskenduda tunnetus- ja õpioskuste kui traditsiooniliselt akadeemiliste oskuste valdkonnale. Laste üldoskuste arendamiseks vajaksid õpetajad koolitusi, mis oleksid seotud pigem tegevuste leidmise ja tulemuse hindamisega, mitte üldoskuste olulisuse teadvustamisega.
Summary