bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Control for the Thin Film Equation: Convergence of a Multi-Parameter Approach to Track State Constraints Avoiding Degeneracies
Authors: Klein Markus , Prohl Andreas 
Published: September 2016

Abstract
We consider an optimal control problem subject to the thin-film equation.
The PDE constraint lacks well-posedness for general right-hand sides due to possible degeneracies; state constraints are used to circumvent this problematic issue and to ensure well-posedness. Necessary optimality conditions for the optimal control problem are then derived. A convergent multi-parameter regularization is considered which addresses both, the possibly degenerate term in the equation and the state constraint. Some computational studies are then reported which evidence the relevant role of the state constraint, and motivate proper scalings of involved regularization and numerical parameters.
Workfare Schemes as a Tool For Preventing the Further Impoverishment of the Rural Poor
Authors: Keller Judit , Kovács Katalin , Rácz Katalin , Swain Nigel , Váradi Monika 
Published: September 2016

Abstract
This article examines workfare schemes in rural Hungary and their contribution to relieving rural poverty. It does so on the basis of an analysis of European Union statistics and a series of semi-structured interviews which were conducted in 2013-2015 as part of a larger project investigating the contemporary state of rural Hungary. The paper comprises four sections: following a short description of the methodology, regional disparities and deprivation in rural areas are introduced with the help of a typology on deprivation and Eurostat data, thus providing evidence for European comparison. Following this, the main findings of our extensive qualitative research into workfare policies in rural Hungary are introduced and discussed on the basis of related legislation4. The article finds that workfare schemes in the rural sector are unique to Central and Eastern Europe, and are especially favoured in Hungary; it also discovers that economists are correct in assessing that said workfare schemes create few new jobs. Nevertheless, they are ‘better than nothing’, and have become embedded in rural society, where they are appreciated by beneficiaries and local officials alike. They necessarily make a paternalistic distinction between the deserving and undeserving poor, and the more commercially-oriented schemes raise issues of market distortion.
From State-Socialist Ambitions of Romanian Rural Indutrialisation to Post-Socialist Rural Deindutrialisation: Two Case Studies From Romania
Authors: Jucu Ioan Sebastian 
Published: September 2016

Abstract
The post-socialist changes in Romania’s communities profoundly changed the rural settlements with similar, contrasting and tensioned trends in the local rural development. The purpose of this study is to focus on the post-socialist rural dereliction. The paper unveils the post-socialist rural transformation in Romania, from the state-socialist interventions in rural industrialisation, to the post-socialist rural identity formation, using both quantitative and qualitative methods. During this process, two sampled case studies were thoroughly analysed, namely the Tomeşti and Margina communes – two rural settlements intensely industrialised under the former state-socialist political regime and with multiple consequences during the post-90s period in their local development. According to recent theories on economic changes reflected in local rural spatial development, the idea of rural dereliction remains peripheral and, at the same time, a hot-spot issue in the contemporary research on rural restructuring. In addition, recent theories on social and economic changes provide useful frameworks in studying the production of rural ruins. With post-socialist deindustrialisation, and under new post-90 capitalist rules in local rural development, rural communities faced multiple problems in creating their own post-socialist identity. Accordingly, this study highlights the local problems of rural deindustrialisation in the inner rural pattern of the investigated sites. While some rural communities embrace slow rural spatial regeneration trends, others remain ruined, marginalised and declined. The findings of the study confirm the presence of derelict abandoned places, thus highlighting the need for further proper interventions in local rural development, and for further fertile scientific dialogues to promote suitable strategies in Romanian rural regeneration on the local scale.
Education Quality and its Drivers in Rural Areas of Poland
Authors: Czyżewski Bazyli , Polcyn Jan 
Published: September 2016

Abstract
A two-stage study was carried out. Firstly, a pioneering attempt was made to measure the quality of education in rural areas of Poland, by county (powiat), using a synthetic indicator. Secondly, the socioeconomic determinants of that quality were modelled. A strength of this study is the fact that it covers the entire population of the given type of administrative units. The analysis served to verify the hypothesis that exogenic socioeconomic factors are key to the effectiveness of the educational process in rural areas. It was shown that in Poland the theories of polarised development are more applicable than those of endogenic development. There was observed an inversely proportional effect from the centre–periphery axis on education quality, but, above all, the effect of several gravitational systems, in which there occurs exogenic diffusion of the results of economic growth and progress from the present and former provincial capitals.
Organization of Rural Microbusinesses Under Specific Family Owners Conditions
Authors: Sposito Maylis 
Published: September 2016

Abstract
The Interreg IV-A research project aims at analysing the socioeconomic consequences of disruptive situations in microbusinesses of the rural French-Swiss Jura region. Several researchers are focusing on this topic within the various institutions involved in the project2. I will rather focus on the common characteristics of microbusinesses on either side of the border. These similarities pertain to the overlapping of the family and business spheres, which often involves an overlapping of statuses, and to the gender relations induced by this overlapping, as well as to the precarious economic situation of these small structures. This article aims at putting into perspective the typology originated by all the biographical interviews collected. This typology compares the figure of the family business heir to that of the self-taught entrepreneur. Such a difference in achieving professional independence brings about strategic patterns of separation/fusion between private and professional lives, patterns which are specific to each above-mentioned ideal type. This typology is yet to be refined, but it already draws attention to the strategies developed by players to separate - or not - family and business spheres. Thus, by tackling the issue of disruption through this typology of company managers, the article will show various influential elements in the event of a disruption, both on the viability of the company and on the personal itinerary of the people involved.
Sinc-Galerkin Technique for the Numerical Solution of Fractional Volterra–Fredholm Integro-Differential Equations with Weakly Singular Kernels
Authors: Sahu P. K. , Saha Ray S. 
Published: September 2016

AbstractThe sinc-Galerkin method is developed to approximate the solution of fractional Volterra–Fredholm integro-differential equations with weakly singular kernels. The proposed method is based on the sinc function approximation. Usually, this type of integral equations is very difficult to solve analytically as well as numerically. The present method applied to the integral equation reduces to solve the system of algebraic equations. Also the numerical results obtained by sinc-Galerkin method have been compared with the results obtained by existing methods. Illustrative examples have been discussed to demonstrate the validity and applicability of the presented method.
Blepharospasm: an uncommon adverse effect caused by long-term administration of olanzapine
Authors: Arora Tarun , Maharshi Vikas , Rehan Harmeet S. , Nagar Pravesh 
Published: September 2016

Abstract

Background:
Blepharospasm is one of the components of drug-induced Meige’s syndrome which is reported to be caused by typical antipsychotics. Reports of blepharospasm or Meige’s syndrome caused by atypical antipsychotics are rare.

Case:
A 30-year-old female patient presented to psychiatry out patient department (OPD) with chief complaints of inability to keep her eyes open for long and excessive blinking for 2 months, irritation of eyes, watery discharge from eyes and photophobia for last 1 month. The patient had been taking olanzapine 10 mg, sertraline 100 mg and divalproex sodium 500 mg per orally on once a day basis for the management of major depressive disorder with psychotic features for last 6 months. Routine blood analysis, thyroid function, EEG, MRI, lipid profile did not reveal any abnormality. Ocular examination was also within normal limits. Olanzapine was suspected as a culprit for the above symptoms of patient, so it was replaced with quetiapine 25 mg/day. Patient showed partial recovery of symptoms within 1 week and complete recovery within 2 months of stopping olanzapine. Causality of olanzapine-induced blepharospasm as per WHO-UMC scale was probable.

Conclusions:
Olanzapine (atypical antipsychotics) should also be kept in the list of suspected drugs causing blepharospasm in psychotic patients on treatment although further similar evidences from observational studies and/or reports are needed to establish the causal relationship.
Maya Intimacy with the Mountains: Pilgrimage, Sacrifice and Existential Economy
Authors: Kapusta Jan 
Published: September 2016

AbstractIn this paper, I present two very different and yet very similar ethnographic examples of mountain-related pilgrimage and sacrifice ritual performed by the present-day highland Maya. The question I ask is why the sense of sacredness, animation and power of the mountains endures among the traditionalist as well as Pentecostal Maya in spite of the extensive transformations of the world today. In so doing, I examine the native concept of the mountain not merely as a social or cultural representation, but as an expression of everyday lived experiences and existential relationships between people and the physical and spiritual world they inhabit. Finally, I argue that the experience of interaction, communication and intimacy between the Maya and their mountain deities can be best defined as a dynamic participation in the course of the world – an existential economy of ‘working the world’.
Exú’s Work – The Agency of Ritual Objects in Southeast Brazilian Umbanda
Authors: Lundell Eleonora A. 
Published: September 2016

Abstract
This article* concentrates on the material side of religious intimacy in Afro-Brazilian Umbanda through an ‘ontographic’ perspective as well as looking at materiality as evidence. It is based on an eleven-month fieldwork period among devotees, clients and individual practitioners of Umbanda in Southeast Brazilian metropolises, especially in São Paulo. In people’s experiences of spiritual work (trabalho) and spiritual development (desenvolvimento) carried out with Exús – guardians, guides and protectors who have, after their death, returned in order to work for people’s wellbeing – ritual objects (such as bodies, clothes, beverages, herbs, cigarettes, candles, songs) are seen as constitutive in knowledge production and life transformation. The central claim in this article is that diverse material and immaterial objects through which Exús interact and materialise, are neither primarily symbolic nor representative, but are re-configurative.
Fertility and sexual function: a gap in training in pediatric endocrinology
Authors: Nahata Leena , Ziniel Sonja I. , Garvey Katharine C. , Yu Richard N. , Cohen Laurie E. 
Published: September 2016

AbstractBackground:Infertility and sexual dysfunction result from many different pediatric conditions and treatments and can profoundly impact quality of life. The American Academy of Pediatrics (AAP) has recommended consulting “fertility specialists” for counseling, but it remains unclear who these specialists are. Our objective was to assess whether pediatric subspecialists who manage hypogonadism and/or genitourinary conditions feel adequately trained to provide fertility and sexual function counseling.Methods:An online survey was distributed to members of Pediatric Endocrine Society (PES), Society for Pediatric Urology (SPU), and North American Society for Pediatric and Adolescent Gynecology (NASPAG). Providers’ comfort in counseling various age groups about fertility and sexual function was assessed via a five-point Likert scale. Providers reported whether they felt adequately trained in these areas.Results:Two hundred and eighty-four surveys were completed by endocrinologists, 124 surveys by urologists, and 41 surveys by gynecologists. Respondents (44% male, 86% Caucasian) represented 39 states and Canada. Seventy-nine percent were at academic centers. Thirty-four percent of providers had been practicing for >20 years. Comfort level was variable and lowest in young males. Ninety-one percent of pediatric endocrinologists reported routinely seeing patients at risk for infertility, but only 36% felt adequately trained in fertility, and 25% felt adequately trained in sexual function.Conclusions:Infertility and sexual dysfunction are often overlooked in pediatric care. Our results suggest that pediatric endocrinologists, who frequently manage male and female hypogonadism, should also receive formal training in these areas. Optimizing counseling would help prevent missed opportunities for fertility preservation and alleviate distress among patients and families.
Prevalence and risk factors for diabetic retinopathy in a hospital-based population of Australian children and adolescents with type 1 diabetes
Authors: Keel Stuart , Itsiopoulos Catherine , Koklanis Konstandina , Vukicevic Meri , Cameron Fergus , Brazionis Laima 
Published: September 2016

AbstractBackground:The aim of this study was to investigate the prevalence of, and traditional and emerging risk factors associated with, retinopathy in a hospital-based population of Australian children and adolescents with type 1 diabetes.Methods:This was a cross-sectional study of 483 children and adolescents with type 1 diabetes. Medical files were audited to collect all relevant clinical data. Diabetic retinopathy was assessed from colour retinal images by an ophthalmologist.Results:Diabetic retinopathy was observed in 11 (2.3%) participants. Logistic regression revealed that the principal components analysis derived risk profile of: higher serum creatinine, older age, higher systolic blood pressures, higher body mass index, abnormal estimated glomerular filtration rate (eGFR) (<59 mL/min), lower high density lipoproteins (HDL) cholesterol, higher serum sodium, longer duration of diabetes and narrower retinal arteriolar calibre was associated with diabetic retinopathy (ExpB=2.60, 95% CI 1.36/4.96, p=0.004).Conclusions:These results support the concept that the pathogenesis of diabetic retinopathy is likely due to the combined influence of various risk factors, many already identified.
Diagnostic relevance of circulating cell-free and exosomal microRNAs and long non-coding RNAs in blood of cancer patients
Authors: Schwarzenbach Heidi 
Published: September 2016

Abstract
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) belong to a large group of non-coding RNA (ncRNA) molecules that possess diverse functions in epigenetic and chromatin structure modifications. In particular, they post-transcriptionally inhibit the protein expression of their target mRNAs and therefore, are involved in different tumor-associated signaling pathways. As the expression of both ncRNAs is frequently dysregulated in cancer and shows unique signatures, they may play a crucial role in cancer pathogenesis. They are passively and actively released into the blood circulation, and accordingly, their plasma/serum and exosomal profiles reflect disease development, tumor load and malignant progression towards metastatic relapse. Considering the biology and nature of ncRNAs in the regulation of different cellular processes, they may have potential clinical utility as blood-based tumor markers and future therapeutic targets in the treatment of cancer patients. The present review focuses on the diagnostic value of cell-free and exosomal ncRNAs in plasma/serum of cancer patients and the challenges to establish them as future tumor markers.
Detection and characterization of circulating cell free tumor DNA in cancer patients with malignant solid tumors. Liquid biopsy: a new tool in molecular pathology?
Authors: Hinrichsen Tanja , Dworniczak Juliane K. , Wachter Oliver , Dworniczak Bernd , Dockhorn-Dworniczak Barbara 
Published: September 2016

Abstract:
The term liquid biopsy comprises methods of blood-based analysis of nucleic acids, which are increasingly under discussion in oncology and personalized medicine, and are already applied in individual cases. The analysis of tumor markers, which in certain tumor diseases can be found as protein markers in vast amounts in the blood, constitutes a primary form of liquid biopsy. Cell-free circulating DNA fragments in the blood (ctDNA), which reflect the genetic profile of a tumor cell and are released in different ways by the tumor, represent a new class of more specific and sensitive biomarkers that can be correlated with the dynamics of the tumor disease. New technologies based on PCR and sequencing techniques pave the way for diagnostic approaches to define molecular tumor characteristics, not only in tumor tissue but also in the blood, by analyzing cell-free circulating DNA. The combination of molecular profiling of the tumor with ctDNA analytics by liquid biopsy is a promising step in the advancement of precision medicine.
Synthesis, characterization and biological evaluation of a well dispersed suspension of gallium-68-labeled magnetic nanosheets of graphene oxide for in vivo coincidence imaging
Authors: Fazaeli Yousef , Rahighi Reza , Tayyebi Ahmad , Feizi Shahzad 
Published: September 2016

Abstract
Graphene oxide (GO) nanosheets were hybridized with Fe3O4 nanoparticles (NPs) to form magnetic GO (MGO) and were further labeled by [68Ga]GaCl3 as a potential drug delivery system. Paper chromatography, Fourier transform infra red (FTIR) spectroscopy, low-angle X-ray diffraction (XRD), CHN and atomic force microscopy (AFM) were utilized to characterize the trinary composite ([68Ga]@MGO). Biological evaluations of the prepared nanocomposite were performed in normal Sprague Dawley rats and it was found to be a possible host for theranostic radiopharmaceuticals. The results showed that the grafting of Fe3O4 NPs on nanocomposite reduced the unwanted liver and spleen uptakes and increased the ratio of kidney/liver uptake from 0.037 to 1.07, leading to the fast removal of radioactive agent and less imposed radiation to patients. The high level of hydrogen bonding caused by the presence of functional groups is responsible for this effect. Considering the accumulation of the tracer in vital organs of rat (especially brain), efficient iron oxide grafting, fast wash-out, the short half-life gallium-68 and less imposed radiation doses to patients, this nanocomposite could be a suitable candidate for positron emission tomography (PET) studies and imaging applications.
The Wheeler–DeWitt Equation in Filćhenkov Model: The Lie Algebraic Approach
Authors: Panahi H. , Zarrinkamar S. , Baradaran M. 
Published: September 2016

Abstract
The Wheeler–DeWitt equation in Filćhenkov model with terms related to strings, dust, relativistic matter, bosons and fermions, and ultra stiff matter is solved in a quasi-exact analytical manner via the Lie algebraic approach. In the calculations, using the representation theory of sl(2), the general (N+1)-dimensional matrix equation is constructed whose determinant yields the solutions of the problem.
Two new POM-based compounds containing a linear tri-nuclear copper(II) cluster and an infinite copper(II) chain, respectively
Authors: Tian Ai-xiang , Ning Ya-li , Ni Huai-ping , Hou Xue , Xiao Ru , Ying Jun 
Published: September 2016

Abstract
Using the pendent organic ligand 1-butyl-1H-(1,3,4)triazole (btz), two new polyoxometalate (POM)-based compounds, [Cu3(btz)6(H2O)4(H3P2W18O62)2]·6H2O (1) and [Cu2(btz)(tz)(H2O)2(SiMo12O40)]·5H2O (2) (tz=1H-(1,3,4)triazole), have been synthesized under hydrothermal conditions. In compound 1, three CuII ions are fused by six btz ligands to form a linear tri-nuclear CuII cluster, with water as bridging molecules. Two Wells-Dawson anions offer two terminal O atoms to link two apical CuII atoms of this tri-nuclear cluster. In compound 2, the btz and tz molecules connect CuII ions to construct an infinite CuII chain still with water molecules as bridges. The adjacent chains are linked by one type of POM anions to build a 2D grid-like layer. Considering the long-range coordinative Cu–O bonds, the other types of POM anions connect adjacent layers to form a 3D framework. The electrochemical and photocatalytic properties of compounds 1 and 2 were also studied.
Synthesis of copper(II) and gold(III) bis(NHC)-pincer complexes
Authors: Jürgens Eva , Back Oliver , Mayer Johannes J. , Heinze Katja , Kunz Doris 
Published: September 2016

Abstract
CuII and AuIII chlorido complexes bearing the bis(NHC) carbazolide pincer ligand (bimca) were synthesized by transmetallation from the respective lithium complex [Li(bimca)] (NHC=N-heterocyclic carbene). In the case of copper, two different molecular structures were obtained depending on the copper source. With Cu(II) chloride the paramagnetic mononuclear [Cu(bimca)Cl] complex is formed and has been characterized by EPR spectroscopy and X-ray structure analysis, while copper(I) chloride leads under oxidation to a dinuclear structure in which two cationic [CuII(bimca)] moieties are bridged by one chlorido ligand. The positive charge is compensated by the [CuCl2]− counter ion, as proven by X-ray structure analysis. Transmetallation of [Li(bimca)] with AuCl3 leads to the [Au(bimca)Cl]+ complex with a tetrachloridoaurate counter ion.
Genetic Mapping by Bulk Segregant Analysis in Drosophila: Experimental Design and Simulation-Based Inference
Authors: Pool John E 
Published: September 2016

Abstract
Identifying the genomic regions that underlie complex phenotypic variation is a key challenge in modern biology. Many approaches to quantitative trait locus mapping in animal and plant species suffer from limited power and genomic resolution. Here, I investigate whether bulk segregant analysis (BSA), which has been successfully applied for yeast, may have utility in the genomic era for trait mapping in Drosophila (and other organisms that can be experimentally bred in similar numbers). I perform simulations to investigate the statistical signal of a quantitative trait locus (QTL) in a wide range of BSA and introgression mapping (IM) experiments. BSA consistently provides more accurate mapping signals than IM (in addition to allowing the mapping of multiple traits from the same experimental population). The performance of BSA and IM is maximized by having multiple independent crosses, more generations of interbreeding, larger numbers of breeding individuals, and greater genotyping effort, but is less affected by the proportion of individuals selected for phenotypic extreme pools. I also introduce a prototype analysis method for simulation-based inference for BSA mapping (SIBSAM). This method identifies significant QTL and estimates their genomic confidence intervals and relative effect sizes. Importantly, it also tests whether overlapping peaks should be considered as two distinct QTL. This approach will facilitate improved trait mapping in Drosophila and other species for which hundreds or thousands of offspring (but not millions) can be studied.