bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinico‐radiological features and next generation sequencing of pulmonary epithelioid hemangioendothelioma: A case report and review of literature
Authors: Mao Xiaoyong , Liang Zibin , Chibhabha Fidelis , Ou Wei , Li Ning , Xu Pengfei , Wang Siyu 
Published: August 2017

Epithelioid hemangioendothelioma is a very rare, vascular, low‐grade malignant tumor found in the lungs, liver, bone, and other soft tissues. Most patients with pulmonary epithelioid hemangioendothelioma (PEH) are asymptomatic but usually present with multiple bilateral nodular lesions in the lungs. Currently, surgical lung biopsy, histology, and immunohistochemical methods are essential for diagnosis. However, there is no standard therapy for the treatment for PEH.Our paper describes the clinico‐radiologic features and genomics of PEH based on next‐generation sequencing (NGS) in a 43‐year‐old male we encountered. The patient came to the hospital with right chest pain. After investigation, a lesion in the middle lobe of the right lung was found, together with smaller multiple lesions in both lungs. After resection of the lesion, histopathological analysis showed positive findings for PEH. The patient's blood and tumor tissue were sent for NGS analysis for further investigation. Results from the analysis revealed mutations of multiple genes. The information obtained from the genomic analysis of PEH using NGS may be significant for the planning and monitoring of treatment for this disease.
A novel combination of peripheral nerve blocks for arthroscopic shoulder surgery
Authors: Musso D. , Flohr‐Madsen S. , Meknas K. , Wilsgaard T. , Ytrebø L. M. , Klaastad Ø. 
Published: August 2017

BackgroundInterscalene brachial plexus block is currently the gold standard for intra‐ and post‐operative pain management for patients undergoing arthroscopic shoulder surgery. However, it is associated with block related complications, of which effect on the phrenic nerve have been of most interest. Side effects caused by general anesthesia, when this is required, are also a concern. We hypothesized that the combination of superficial cervical plexus block, suprascapular nerve block, and infraclavicular brachial plexus block would provide a good alternative to interscalene block and general anesthesia.MethodsTwenty adult patients scheduled for arthroscopic shoulder surgery received a combination of superficial cervical plexus block (5 ml ropivacaine 0.5%), suprascapular nerve block (4 ml ropivacaine 0.5%), and lateral sagittal infraclavicular block (31 ml ropivacaine 0.75%). The primary aim was to find the proportion of patients who could be operated under light propofol sedation, without the need for opioids or artificial airway. Secondary aims were patients' satisfaction and surgeons' judgment of the operating conditions.ResultsNineteen of twenty patients (95% CI: 85–100) underwent arthroscopic shoulder surgery with light propofol sedation, but without opioids or artificial airway. The excluded patient was not comfortable in the beach chair position and therefore received general anesthesia. All patients were satisfied with the treatment on follow‐up interviews. The surgeons rated the operating conditions as good for all patients.ConclusionThe novel combination of a superficial cervical plexus block, a suprascapular nerve block, and an infraclavicular nerve block provides an alternative anesthetic modality for arthroscopic shoulder surgery.
Acute generalized exanthematous pustulosis and polyarthritis associated with a novel CARD14 mutation
Authors: Podlipnik Sebastian , Castellanos‐Moreira Raul , Florez‐Enrich Helena , Arostegui Juan Ignacio , Mascaró José Manuel 
Published: August 2017

AbstractAcute generalised exanthematous pustulosis (AGEP) is a rare toxicoderma characterised by an acute onset rash, with many sterile pustules on the surface, high fever and increased acute phase reactants. We report the case of a patient who presented to the dermatology department with an AGEP and polyarthritis, in which a novel CARD14 mutation was identified. The pathophysiological mechanism of AGEP remains unclear, although mutations in the IL36RN gene have been identified in a small subset of AGEP patients. Similarly, mutations in the CARD14 gene have been linked to pustular types of psoriasis and familiar cases of pityriasis rubra pilaris; however, there are no reports associating mutations in the CARD14 gene with AGEP.
Psychosocial functioning, self‐image, and quality of life in children and adolescents with neurofibromatosis type 1
Authors: Cipolletta S. , Spina G. , Spoto A. 
Published: August 2017

AbstractBackgroundNeurofibromatosis type 1 (NF1) is a genetic disorder associated with neurocutaneus manifestations, as well as attention and learning problems. The aim of this study was to examine the psychosocial functioning, quality of life, and self‐image of children with NF1.MethodTwo hundred forty participants were recruited, comprising 60 children and adolescents with NF1, 60 parents of children with NF1, 60 children and adolescents without NF1, and 60 parents of children without NF1. The children/adolescents completed the Self‐administered Psychiatric Scales test for Children and Adolescents and the human figure drawing test, whereas parents completed the Child Behavior Checklist. Both children and parents completed the Pediatric Quality of Life Inventory.ResultsCompared to healthy subjects, individuals with NF1 reported anxiety problems, poorer quality of life, and greater distortions in terms of self‐image. When compared to healthy participants' parents, the parents of NF1 participants reported having more concerns about the quality of life, sociality, school performance, and attention span of their children.ConclusionsResults show that the psychological functioning, behavior, self‐image, and quality of life of children and adolescents with NF1 are compromised. Health services should take into account the psychosocial difficulties associated with NF1 and design rehabilitation programs aimed at increasing NF1 children's interpersonal skills, improving their social life and quality of life, and promoting more adaptive behaviors. In addition, health care interventions should also involve the parents of children with NF1.
Comparison of Hill‐radial basis function, Barrett Universal and current third generation formulas for the calculation of intraocular lens power during cataract surgery
Authors: Roberts Timothy V , Hodge Chris , Sutton Gerard , Lawless Michael ,   contributors to the Vision Eye Institute IOL outcomes registry
Published: August 2017

AbstractImportanceThis study represents a novel comparison of recently introduced intraocular lens power calculation formulas.BackgroundTo compare current new generation formulas for calculating the intraocular lens power for a standard cohort of patients undergoing cataract and lens replacement surgery in a private group practice in Australia.DesignRetrospective case series comparison.ParticipantsPostoperative results from 400 consecutive patients undergoing implantation of an SN60WF intraocular lens post cataract removal by 12 surgeons were used.MethodsRefractive outcomes were compared with expected targets to determine the predicted refractive outcomes using the Hill‐radial basis function, Barrett Universal II and readily available third or fourth generation intraocular lens power calculation formulas.Main Outcome MeasureMean absolute predicted error.ResultsThe mean absolute predicted difference ranged from 0.30 to 0.34 D. There was no overall significant difference in the predicted difference or variance between formulas. All formulas achieved greater than 78.3% of eyes within ±0.5 D of intended refraction. The Hill‐radial basis function and Barrett formulas provided the lowest mean numerical error compared with existing formulas in short and long eyes, respectively. The Barrett Universal II formula had the lowest percentage of refractive surprises (>1 D from predicted error) across all axial lengths.Conclusions and RelevanceAcceptable outcomes can be achieved with optical biometry, consistent surgical technique and use of current intraocular lens power calculation formulas. The Barrett Universal II formula may provide the lowest risk of refractive surprise compared with other intraocular lens power calculation formulas.
Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes: in search of the culprit allergen
Authors: Schuttelaar Marie L. , Meijer Joost M. , Engfeldt Malin , Lapeere Hilde , Goossens An , Bruze Magnus , Persson Christina , Bergendorff Ola 
Published: August 2017

SummaryBackgroundDuring rubber vulcanization, new compounds can be formed.ObjectivesTo report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS).MethodsA female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials. Thin‐layer chromatography (TLC) was performed for additional patch testing, and high‐performance liquid chromatography and gas chromatography–mass spectometry were used for chemical analysis.ResultsPositive reactions were found to thiuram mix (+), tetramethylthiuram monosulfide (TMTM) (+), shoe material (+), and shoe extracts in eth. (++) and acetone (+). The extracts did not contain TMTM or other components of thiuram mix. TLC strips yielded a positive reaction (+) to one spot, whereas chemical analysis gave a negative result. Thereafter, a similar sneaker from another patient with shoe dermatitis was analysed, and DMBTS was identified. New extracts of the shoe of our first patient were then also shown to contain DMTBS. DMTBS as culprit allergen was confirmed by positive patch testing with a dilution series with DMTBS.ConclusionDMBTS was identified as the culprit allergen in shoe dermatitis, giving rise to compound allergy. The positive reaction to TMTM was considered to represent cross‐reactivity.
Timely access to care in the treatment of rectal cancer and the effect on quality of life
Authors: Walming S. , Block M. , Bock D. , Angenete E. 
Published: August 2017

AbstractAimThe aim of this study was to investigate if a delay in a patient's first contact with a healthcare professional, and any subsequent delay in diagnosis, affected self‐assessed quality of life prior to start of treatment for rectal cancer.MethodQuestionnaires were administered when patients had been informed of the diagnosis and planned treatment. The primary end‐point was self‐assessed quality of life according to a seven‐point Likert scale. The response variables were dichotomized and analysed by unadjusted and adjusted binary logistic regression.ResultsA reported duration of symptoms longer than 4 months was found to be associated with a lower quality of life than a reported duration of symptoms of less than 3 months. Furthermore, a reported period of longer than 2 months from first contact with a healthcare professional to a diagnosis was found to correlate with lower quality of life compared with a period shorter than 2 months. However, when adjusting for possible confounding variables the duration of symptoms and time to diagnosis were not found to affect self‐assessed quality of life. Several variables were found to have significant influence in the statistical model, including sense of coherence, the presence of negative intrusive thoughts, comorbidity, depressed mood, male sex and comorbidity.ConclusionOne conclusion of our study is that further efforts to shorten delay in rectal cancer care with the aim of improving quality of life may be futile. To improve the patient's quality of life at diagnosis other interventions should be considered, such as screening for depression and/or negative intrusive thoughts.
Efficacy and pharmacokinetics of subcutaneous exendin (9‐39) in patients with post‐bariatric hypoglycaemia
Authors: Craig Colleen M. , Liu Li‐fen , Nguyen Thi , Price Candice , Bingham Justus , McLaughlin Tracey L. 
Published: August 2017

AimTo evaluate the efficacy, pharmacokinetic (PK) profile and tolerability of subcutaneous (s.c.). exendin 9‐39 (Ex‐9) injection in patients with post‐bariatric hypoglycaemia (PBH).MethodsNine women who had recurrent symptomatic hypoglycaemia after undergoing Roux‐en‐Y gastric bypass were enrolled in this 2‐part, single‐blind, single‐ascending‐dose study. In Part 1, a single participant underwent equimolar low‐dose intravenous (i.v.) vs s.c. Ex‐9 administration; in Part 2, 8 participants were administered single ascending doses of s.c. Ex‐9 during an oral glucose tolerance test (OGTT). Glycaemic, hormonal, PK and symptomatic responses were compared with those obtained during the baseline OGTT.ResultsAlthough an exposure–response relationship was observed, all doses effectively prevented hyperinsulinaemic hypoglycaemia and improved associated symptoms. On average, the postprandial glucose nadir was increased by 66%, peak insulin was reduced by 57%, and neuroglycopenic symptoms were reduced by 80%. All doses were well tolerated with no treatment‐emergent adverse events observed.ConclusionsInjection s.c. of Ex‐9 appears to represent a safe, effective and targeted therapeutic approach for treatment of PBH. Further investigation involving multiple doses with chronic dosing is warranted.
Sex pheromone of the iris gelechiid moth Monochroa divisella
Authors: Tabata Jun , Kubota Sakae 
Published: August 2017

AbstractThe iris gelechiid moth, Monochroa divisella (Douglas) (Lepidoptera: Gelechiidae), is a serious pest in iris horticulture. The overuse of pesticides for conventional control has a great risk of water pollution because irises are often planted in damp areas. To minimize pesticide applications, it is essential to monitor moth emergence by using pheromone traps. The female pheromone of M. divisella was analyzed by means of gas chromatography‐electroantennographic detection (GC‐EAD) and GC‐mass spectrometry. Two male EAD‐active compounds were detected and identified as (Z)‐3‐dodecenyl acetate (Z3‐12:Ac) and (Z)‐5‐tetradecenyl acetate (Z5‐14:Ac), the amounts of which were ca. 40 and 6 ng per female (100:15), respectively. Synthetic Z3‐12:Ac alone attracted only a few males in field trap experiments, but the attractiveness was significantly enhanced when 15% (wt/wt) Z5‐14:Ac was added; traps baited with their binary mixtures captured 21.3‐106.4 males/trap/day, as compared with 2.3 males/trap/day attracted by a crude extract of 10 virgin females. We conclude that Z3‐12:Ac and Z5‐14:Ac are M. divisella pheromone components, which can be offered as an attractant in monitoring traps. Although dodecenyl acetates are a major class of lepidopteran pheromone components, those with the double bond at the 3 position are rare and appear to be unique to gelechiids.
Poor geotaxis correlated with haematoporphyrin‐induced peroxidation of brain lipids as a predictor of medfly longevity reduction
Authors: Bochicchio Pablo A. , Pérez Martín M. , Quesada‐Allué Luis A. , Rabossi Alejandro 
Published: August 2017

AbstractUnder illumination conditions, porphyrins generate cytotoxic radicals in cells. Our study evaluated the effects of haematoporphyrin IX (HP IX) in a laboratory population of male Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) during exposure to a low fluence rate (39 μE m−2 s−1) of light. We found that exposing flies to HP IX for at least 5 days was sufficient to cause irreversible damage that led to anticipated death, as also provoked by chronic exposure to the same concentration. To identify early indicators of the accelerated senescence, we analysed both in vitro and in vivo parameters. The thiobarbituric acid reactive substances content in the heads of treated flies revealed a significant increase in lipid hydroperoxides at day 10, whereas this occurred several days later in controls. In addition, a significant decrease in glycogen content was observed at 15 days of age, 5 days before the reduction observed in the control group. This decrease has been associated with a decline in locomotor activity. Differences in the distribution of flies in the rearing flasks were observed, reflecting an impairment of the motility and climbing capacity of HP IX‐treated flies. This finding was also corroborated by a geotactic response assay (a rapid iterative negative geotaxis or RING assay). The results presented here demonstrate that low‐lethal oxidative stress can anticipate the senescence of flies, which can be predicted using a simple and fast behavioural test, such as the RING assay.
Effect of semiochemicals and trap height on catch of Neocerambyx raddei in Jilin province, China
Authors: Li Yan , Meng Qingfan , Silk Peter , Gao Wentao , Mayo Peter , Sweeney Jon 
Published: August 2017

AbstractWe conducted experiments in Jilin, China, in 2011 and 2014 in forest stands dominated by mature Quercus mongolica Fisch. ex Ledeb. (Fagaceae) to test the effects of longhorn beetle pheromones, plant volatiles, and trap height on catch of Neocerambyx raddei (Blessig & Solsky) (formerly Massicus raddei) (Coleoptera: Cerambycidae) in traps. Traps captured 276 specimens of N. raddei in 2011 and 379 specimens in 2014 (384 females, 271 males). Ethanol was attractive to female but not male N. raddei. However, N. raddei was not attracted to any of the longhorn beetle pheromones tested, which included racemic 3‐hydroxyhexan‐2‐one, racemic 3‐hydroxyoctan‐2‐one, syn‐2,3‐hexanediols, anti‐2,3‐hexanediols, racemic E,Z‐fuscumol, racemic E,Z‐fuscumol acetate, and monochamol, nor was it attracted to 2‐methyl‐3‐buten‐2‐ol. Traps placed in the tree canopy captured significantly more beetles than did traps in the understorey. Our results suggest that surveys for N. raddei should use ethanol‐baited traps placed in the tree canopy. If sex or aggregation pheromones are identified for N. raddei in the future, we predict that attraction to them will be enhanced by the presence of ethanol.
Rainfall variability and fine‐scale life history tradeoffs help drive niche partitioning in a desert annual plant community
Authors: Shriver Robert K. 
Published: August 2017

AbstractTradeoffs have long been an essential part of the canon explaining the maintenance of species diversity. Despite the intuitive appeal of the idea that no species can be a master of all trades, there has been a scarcity of linked demographic and physiological evidence to support the role of resource use tradeoffs in natural systems. Using five species of Chihuahuan desert summer annual plants, I show that demographic tradeoffs driven by short‐term soil moisture variation act as a mechanism to allow multiple species to partition a limiting resource. Specifically, by achieving highest fitness in either rainfall pulse or interpulse periods, variability reduces fitness differences through time that could promote coexistence on a limiting resource. Differences in fitness are explained in part by the response of photosynthesis to changing soil moisture. My results suggest that increasing weather variability, as predicted under climate change, could increase the opportunity for coexistence in this community.
Depression among older people in Sri Lanka: With special reference to ethnicity
Authors: Khaltar Amartuvshin , Priyadarshani Neelawala GW , Delpitiya Nisansala Y. , Jayasinghe Chandrika , Jayasinghe Ananda , Arai Asuna , Tamashiro Hiko 
Published: August 2017

AimTo ascertain if the factors associated with depression differ among ethnic groups in community‐dwelling older people in Kandy District, Sri Lanka.MethodsA cross‐sectional survey was carried out of people aged ≥60 years living in a single divisional secretariat of Kandy District. The participants were asked about ethnicity (Sinhalese, Tamil and Muslim), sociodemographic characteristics and depression status by face‐to‐face interviews with a structured questionnaire. Depression was measured by the 15‐item Geriatric Depression Scale, and the total score of ≥6 was considered as depression. The χ2‐test and multivariate logistic regression with two‐way interaction terms between sociodemographic characteristics and ethnicity were carried out.ResultsParticipants (n = 778) consisted of 56.6% Sinhalese, 22.1% Tamils and 21.3% Muslims. Of the participants, the prevalence of depression was 31.8% (27.3% in Sinhalese, 42.1% in Tamils and 32.9% in Muslims). Multivariate analyses showed that there were no significant interactions between sociodemographic characteristics and ethnicity. However, low economic status, low perceived social support and more than two self‐reported diseases were significantly associated with depression in all ethnic groups.ConclusionsSome factors were found to be significantly associated with depression, but did not differ among ethnic groups. The findings would help practitioners to identify older people with a high risk of depression, and to intervene in its development or exacerbation. Geriatr Gerontol Int 2017; 17: 2414–2420.
Association of care recipients’ care‐need level with family caregiver participation in health check‐ups in Japan
Authors: Sugiyama Takehiro , Tamiya Nanako , Watanabe Taeko , Wakui Tomoko , Shibayama Taiga , Moriyama Yoko , Yamaoka Yui , Noguchi Haruko 
Published: August 2017

AimThe public mandatory long‐term care insurance system in Japan has supposedly mitigated the care burden for family caregivers of older adults, whereas family caregivers still play a considerable role in providing care. The effect of informal caregiving on the caregiver's health has been of great interest. We investigated the relationship between the amplitude of informal caregiving and caregiver participation in health check‐ups in Japan.MethodsThe present study was a cross‐sectional analysis of nationally representative data in Japan (2010 Comprehensive Survey of Living Conditions). We investigated the relationship between care recipients’ care‐need level and in‐home caregiver participation in health check‐ups during the last year of the survey for caregivers.ResultsA total of 3354 caregiver/recipient pairs were included in the study. Crude proportions of caregivers completing a health check‐up by care‐need level were 68.4% (support required 1 and 2), 63.5% (care required 1–3) and 60.3% (care required 4 and 5). Higher care‐need level was negatively associated with caregiver participation in health check‐ups (support required 1 and 2as reference, care required 1–3: odds ratio 0.82, 95% confidence interval 0.75–0.90), care required 4 and 5: odds ratio 0.76, 95% confidence interval 0.74–0.79) after adjustment for possible confounders. Inclusion of the caregiver time devoted to care per day and caregiver self‐rating of health as independent variables did not change the result.ConclusionsThese results suggest that facilitating health check‐up participation for family caregivers of care recipients with higher care‐need levels might be an effective intervention for decreasing the gap in health behavior possibly caused by informal caregiving. Geriatr Gerontol Int 2018; 18: 26–32.