bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge of an inflammatory biomarker of cardiovascular risk leads to biomarker-based decreased risk in pre-diabetic and diabetic patients
Authors: Alcivar-Franco Diego , Purvis Scott , Penn Marc S. , Klemes Andrea 
Published: January 2018

Objective Diabetes is a risk equivalent for cardiovascular events. The increase in vascular inflammation with diabetes is believed to be responsible for increased risk of ischemic events in diabetic patients. Our goal was to assess whether knowledge of vascular inflammation alters cardiovascular risk over time, and how knowledge of vascular inflammation changes risk in non-diabetic, pre-diabetic and diabetic patients. Methods We retrospectively studied >100,000 primary-care patients per annum for 5 years (baseline in 2011 through 2015) with tests including lipoprotein profile, hemoglobin A1C and the vascular-specific inflammation risk marker myeloperoxidase. Results were obtained during the patient’s MD Value In Prevention (MDVIP) annual wellness program physical. Results We show that rates of patients with elevated myeloperoxidase levels were reduced from 14.4%, 15.2% and 21.3% to 4.0%, 4.0% and 6.7% in non-diabetic, pre-diabetic and diabetic patients, respectively, over the 5-year period. Decreases in vascular inflammation were achieved without decreases in the prevalence of pre-diabetes (hemoglobin A1C 5.7%–6.4%) or diabetes (hemoglobin A1C >6.4%) and were observed in patients below or above guideline low-density lipoprotein targets. Conclusions These data demonstrate that physicians informed of elevated markers of vascular inflammation can lower vascular inflammation correlating with biomarker-based decreased risk of cardiovascular events.
Revision Anterior Cruciate Ligament Reconstruction Outcomes in Younger Patients: Medial Meniscal Pathology and High Rates of Return to Sport Are Associated With Third ACL Injuries
Authors: Webster Kate E. , Feller Julian A. , Kimp Alexander J. , Whitehead Timothy S. 
Published: January 2018

Background: There are limited data evaluating the outcomes of revision anterior cruciate ligament (ACL) reconstruction surgery in younger patients despite recent reports that the rates of graft rupture are higher in young cohorts. Purpose: To explore the outcomes of revision ACL reconstruction surgery in younger patients with the specific aims of determining the rates of third ACL injury and whether knee pathology at the time of revision surgery and return to sport were associated with further injury. Study Design: Case-control study; Level of evidence, 3. Methods: The study cohort consisted of 151 consecutive patients who were aged 25 years or younger at the time of their first revision ACL reconstruction. The number of subsequent ACL injuries (graft rerupture or contralateral injury to the native ACL) was determined at a mean follow-up time of 4.5 years (range, 2-9 years). Surgical details were recorded, along with a range of sport participation outcomes. Contingency tables were used to assess the associations between subsequent ACL injury and return to sport, knee pathology, and the drilling of new femoral or tibial tunnels at revision surgery. Results: The follow-up rate was 85% (128/151). Graft reruptures occurred in 20 patients (16%) at a mean time of 2 years after revision surgery. Contralateral ACL injuries occurred in 15 patients (12%) at a mean time of 3.9 years. The total number of patients who had a third ACL injury was 35 (27%). There was a significant association between having medial meniscal pathology and sustaining a graft rerupture ( P = .03), but there was no association between graft rerupture and using the same tunnels from the primary procedure at revision surgery. After revision reconstruction, 68% of patients (95% CI, 55%-71%) returned to their preinjury level of sport, compared with 83% (95% CI, 69%-84%) after primary reconstruction in the same patients. Those who had a third ACL injury had a significantly higher rate of return to preinjury sport (83%) after the revision procedure than did the group that did not have further ACL injuries (62%, P = .02). Conclusion: Younger patients are at significant risk of having multiple ACL injuries. The high rate of third ACL injuries presents a significant issue for future knee health in these young athletes. Medial meniscal pathology and returning to high-risk sport are factors that are significantly associated with the high multiple ACL injury rate in the young.
Using New Case Studies for Evaluation of Marketing Student’s Academic Performance
Authors: Mukherjee Jaydeep 
Published: January 2018

Case method has been a popular pedagogy in management education. It is a preferred evaluation tool which is inherently subjective in nature. This article compares the results of case-based evaluation in marketing discipline, in announced and unannounced settings, for full-time and part-time management programmes and discusses its implications. The data were collected from the formal evaluation made by a faculty of an Association of MBAs (AMBA) accredited management institute of India. The results suggests that for full-time residential MBA programmes, use of relative marks for grading each component of the evaluation is likely to be a more robust evaluation mechanism than using just the marks or using the consolidated marks for final grading. However, neither surprise quiz nor announced quiz provide any robust and unbiased method of evaluating the performance of the students of part-time non-residential MBA programme as the result are also dependent on variables like work and family, which are extraneous to the student’s interest and proficiency in the subject.
RETRACTED ARTICLE: Effects of hPMSCs on granulosa cell apoptosis and AMH expression and their role in the restoration of ovary function in premature ovarian failure mice
Authors: Zhang Hongqin , Luo Qianqian , Lu Xueyan , Yin Na , Zhou Dongli , Zhang Lianshuang , Zhao Wei , Wang Dong , Du Pengchao , Hou Yun , Zhang Yan , Yuan Wendan 
Published: January 2018

Abstract
Background
This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. The aim of this research is to investigate the mechanisms of hPMSCs on ovarian reserve capacity.

Methods
The POF mice model was established by injection of zona pellucida 3 peptide (pZP3). hPMSC transplantation was conducted by intravenous injection into mice following pZP3 treatment. The follicle number was examined by histopathology. The serum levels of FSH, LH, E2, AMH and anti-zona pellucida antibody (AzpAb) were measured by enzyme-linked immunosorbent assay. AMH and FSHR expression in the ovary was analyzed by immunohistochemistry and western blot analysis. Granulosa cell apoptosis of the ovaries was examined by In Situ Cell Death Detection Kit. Granulosa cells were isolated and treated with SiAmh interference and hPMSC supernatant to observe the effects of AMH expression on granulosa cell apoptosis in vitro.

Results
The results showed that hPMSC transplantation can significantly recover the estrus cycle in the POF group. Morphological staining showed that the basal follicles and sinus follicles after hPMSC transplantation were higher in POF mice than in those without treatment, and the follicle number was significantly decreased with atresia. The serum levels of FSH, LH and AzpAb in the hPMSC transplantation group were reduced considerably, but the E2 and AMH levels were significantly increased. After hPMSC transplantation, the AMH and FSHR expression in ovarian tissue was significantly higher than in the POF group as determined by immunochemistry and western blot analysis. The FSHR expression was shown in granulosa cells only, and FSHR expression increases with AMH expressed in the ovary; granulosa cell apoptosis was decreased following hPMSC transplantation. The same results were observed from the in-vitro study.

Conclusions
hPMSC transplantation can significantly improve the serum levels of high gonadotropin and low estrogen of POF mice, promote follicular development, inhibit excessive follicular atresia and granulosa cell apoptosis, and improve the ovarian reserve capacity. The mechanism may be achieved by increasing the expression of AMH and FSHR in ovaries.
TLC separation and antioxidant activity of flavonoids from Carissa bispinosa, Ficus sycomorus, and Grewia bicolar fruits
Authors: Gwatidzo Luke , Dzomba Pamhidzai , Mangena Mkululi 
Published: January 2018

Abstract
Background
Carissa bispinosa, Ficus sycomorus, and Grewia bicolar are edible fruit plants that grow in the wild. The plants produce yellow-, red-, and purple-colored fruits and thus can be good sources of flavonoids for fighting oxidative reactions in humans, food, and the pharmaceutical industry. The present study aimed at isolating flavonoids from C. bispinosa, F. sycomorus, and G. bicolar fruits and determining their antioxidant activity using the 2, 2-diphenyl-1- picrylhydrazyl (DPPH) and 2, 2-azino-bis 3-ethylbenz-thiaz-oline-6-sulfonic acid (ABTS) model radical assays.

Methods
Analytical and preparative thin-layer chromatography was used to isolate flavonoids from the fruits using methanol/chloroform/hexane (7:2:1, v/v/v) as a mobile phase system. The ABTS and DPPH radical scavenging methods were used to test for the antioxidant activity of the samples, using quercetin and catechin as reference standards.

Results
Thin-layer chromatographic profiling revealed two different types of flavonoids from each plant. C. bispinosa yielded two flavonoid bands, Rf values 0.11 and 0.38; G. bicolar yielded two flavonoid bands, Rf values 0.63 and 0.81; and F. sycomorus also yielded two types of flavonoids, Rf values 0.094 and 0.81. All the extracted flavonoids exhibited significant antioxidant activity of over 80% at a concentration of 200 mg/L. The order of radical scavenging activity for the 200-mg/L samples is G. bicolar Rf (0.81) > C. bispinosa Rf (0.113) > F. sycomorus Rf (0.094) > F. sycomorus Rf (0.047) > C. bispinosa Rf (0.38) > G. bicolar Rf (0.63). G. bicolar (Rf = 0.81) exhibited antioxidant activity that was superior to that of catechin.

Conclusion
The present study results show that C. bispinosa, F. sycomorus, and G. bicolar contain different flavonoid types with significant antioxidant activity of over 80% at a concentration of 200 mg/L. Therefore, the fruits can be used as a source of natural antioxidants which can be used as nutraceuticals to promote health, as preservatives to delay peroxidation of foods, and as flavoring for packed foods.
Acute Hypotension After Moderate-Intensity Handgrip Exercise in Hypertensive Elderly People
Authors: Souza Luiz R. , Vicente Joyce B. , Melo Geiziane R. , Moraes Vivian C. , Olher Rafael R. , Sousa Iorrany C. , Peruchi Luiz H. , Neves Rodrigo V. , Rosa Thiago S. , Ferreira Aparecido P. , Moraes Milton R. 
Published: January 2018

AbstractSouza, LR, Vicente, JB, Melo, GR, Moraes, VC, Olher, RR, Sousa, IC, Peruchi, LH, Neves, RV, Rosa, TS, Ferreira, AP, and Moraes, MR. Acute hypotension after moderate-intensity handgrip exercise in hypertensive elderly people.J Strength Cond Res32(10): 2971–2977, 2018—Isometric handgrip (IHG) training is effective in reducing blood pressure (BP), but little is known about the occurrence of acute hypotension by postisometric exercise hypotension (PIEH) and the underlying mechanisms. Ten sedentary hypertensive elderly people (7 women and 3 men) individuals, with a mean age of 73.2 ± 2.2 years and systolic BP (SBP) of 135.1 ± 6.5, were included; they were hypertensive for 13.2 ± 3.1 years and were receiving medications. These patients underwent 2 experimental sessions of isometric exercise using a portable hydraulic handgrip dynamometer: (a) sham session with 3% of maximal voluntary isometric contraction (MVIC) and (b) experimental isometric session with 30% MVIC, completing a total of 8 sets of 1-minute contraction and 1-minute rest-pause (overload of work = 51.7 kgf·min). Blood pressure and heart rate were evaluated at rest and 1, 5, 10, 15, 30, 45, and 60 minutes postexercise. Blood lactate (Lac) and salivary nitric oxide (NO−) were collected at rest, 0, 30, and 60 minutes postexercise. The SBP presented a reduction as of the tenth minute postexercise to session 30% MVIC (Δ = −14.4 at −18.7 mm Hg,p< 0.05). At 60-minute postexercise, the SBP was 30% lower vs. 3% MVIC (−20.2 mm Hg,p= 0.006). There were no differences for the other cardiovascular parameters and vasoactive substances for both sessions (p> 0.05). These results demonstrated that the IHG exercise with a higher overload of work induced PIEH in hypertensive elderly people, but there was no association with Lac and NO−. Therefore, this IHG model with easy execution, quick adherence, short duration, and a portable equipment can be an excellent adjuvant strategy for the control and prevention of hypertension.
Assessing Crack Susceptibility of Asphalt Concrete Mixtures with Overlay Tester
Authors: Garcia Victor M. , Miramontes Alejandro , Garibay Jose , Abdallah Imad , Nazarian Soheil 
Published: January 2018

Abstract
This paper reports on a newly proposed methodology for characterizing asphalt concrete (AC) mixtures with the Overlay Tester (OT). The methodology considers two stages of cracking (i.e., crack initiation and crack propagation). The crack initiation is represented by the critical fracture energy (CFE) parameter obtained from the load displacement curve of the first loading cycle, while the crack propagation is represented by the crack progression rate (CPR) parameter. A design interaction plot of these two parameters is proposed for evaluating and assessing the cracking resistance of AC mixtures. More than 250 OT results from ten different AC mix types were used to set the preliminary acceptance limits for the CFE and CPR parameters. Preliminary implementation suggests that the proposed OT test method is a promising tool for the evaluation of the cracking resistance of AC mixtures.
Identification of Two Distinct Working Memory-Related Brain Networks in Healthy Young Adults
Authors: Egli Tobias , Coynel David , Spalek Klara , Fastenrath Matthias , Freytag Virginie , Heck Angela , Loos Eva , Auschra Bianca , Papassotiropoulos Andreas , de Quervain Dominique J.-F. , Milnik Annette 
Published: January 2018

AbstractWorking memory (WM) is an important cognitive domain for everyday life functioning and is often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies in humans show that distributed brain areas typically described as fronto-parietal regions are implicated in WM tasks. Based on data from a large sample of healthy young adults (N= 1369), we applied independent component analysis (ICA) to the WM-fMRI signal and identified two distinct networks that were relevant for differences in individual WM task performance. A parietally-centered network was particularly relevant for individual differences in task measures related to WM performance (“WM dependent”) and a frontally-centered network was relevant for differences in attention-dependent task performance. Importantly, frontal areas that are typically considered as key regions for WM were either involved in both WM-dependent and attention-dependent performance, or in attention-dependent performance only. The networks identified here are provided as publicly available datasets. These networks can be applied in future studies to derive a low-dimensional representation of the overall WM brain activation.
IMPLEMENTASI METODE GRABBING PADA WEB PENYEDIA INFORMASI BEASISWA
Authors: Dauni Popon , Ferdiana Egi , Slamet Cepy , Atmaja Aldy Rialdy 
Published: January 2018

ABSTRAK Beasiswa adalah pemberian berupa bantuan keuangan dalam pendidikan yang diberikan kepada pelajar yang bertujuan untuk keberlangsungan pendidikannya. Beasiswa tersebut diberikan oleh suatu lembaga pemerintah atau sebuah yayasan. Informasi mengenai beasiswa yang ditawarkan biasanya dapat kita lihat di internet melalui suatu website. Jenis beasiswa yang ditawarkan juga beraneka ragam, baik beasiswa dalam negeri ataupun beasiswa dari luar negeri. Namun, banyaknya penyedia beasiswa yang menggunakan website membuat pencari beasiswa kesulitan untuk mendapat informasi beasiswa dalam satu waktu. Penelitian ini bertujuan untuk membuat portal informasi yang dapat memudahkan para pencari beasiswa untuk mendapatkan informasi yang dibutuhkan. Metode grabbing digunakan dalam penelitian ini untuk mengambil informasi pada suatu halaman website yang dituju, kemudian dikumpulkan dalam satu portal website yang baru. Sehingga, apabila terdapat informasi baru terkait beasiswa dapat dengan mudah untuk didapatkan. Aplikasi ini menggunakan bahasa pemrograman PHP dan menggunakan library cURL dalam berkomunikasi dengan berbagai internet protokol. ABSTRACT The scholarship is a gift of financial assistance to students who aim for continuity of their education. The scholarship can be awarded by a government or foundation. The information of scholarship usually can be accessed on a website by using the internet. There are many types of scholarship such as for domestic and overseas scholarship. However, the amount of scholarship information makes the peoples difficult to find the scholarship exactly at a time. The purpose of research is making a portal information to facilitate scholarship seekers to obtain required information of scholarship. Grabbing method is able to retrieve information on a website and collected in a new website scholarship portal. Thus, if there is a new scholarship information, the portal can be easily obtained getting information. PHP programming language and cURL library are implemented in this research to communicate with various internet protocols.How to Cite : Dauni, P. Ferdiana, E. Selamet, C, Atmadja, A.R. (2017). IMPLEMENTASI METODE GRABBING PADA WEB PENYEDIA INFORMASI BEASISWA. Jurnal Teknik Informatika, 10(2), 169-182. doi:10.15408/jti.v10i2.6823Permalink/DOI: http://dx.doi.org/10.15408/jti.v10i2.6823
Jorge Amado, Pablo Neruda e Nicolás Guillén: História da Literatura, histórias de recepção
Authors: Da Silva Márcia Rios 
Published: January 2018

Neste artigo, propõe-se uma reflexão acerca da trajetória intelectual e literária de Jorge Amado, Pablo Neruda e Nicolás Guillén, tomada como uma dimensão altamente relevante na construção de histórias de recepção, mas ignoradas pela História da literatura. Como intelectuais de esquerda, comprometidos com as questões sociais do seu tempo, esses escritores tornam-se referência em seus países, e no exterior, na defesa da democracia e contra os regimes ditatoriais. Aproximados pela atuação na esfera pública e na vida cultural e pela consagração extraordinária de público, expandiram significativamente a recepção de suas produções literárias, por várias gerações de leitores, o que impõe pensar o engajamento político (SARTRE, 2004) como potência na formação de público. Essa discussão busca apoio nos estudos de recepção (JAUSS, 2009), histórias de literatura (MOREIRA, 2002, OLINTO, 2002) e escrita da história (BURKE, 1992).********************************************************************Jorge Amado, Pablo Neruda and Nicolás Guillén: Literature History and stories of receptionAbstract: The article aims at proposing a reflection about the intelectual and literary pathways of Jorge Amado, Pablo Neruda and Nicolás Guillén taken as a highly relevant dimension in the construction of stories of reception but ignored by Literature History. Being leftist intellectuals, committed with the social issues of their times, these writers became reference in their countries and abroad as being in favor of democracy and against dictatorial regimes. They were brought together by their public attitude as well as in their intelectual lives and were extraordinarily applauded by the people in general. As a result, they expanded significantly the reception of their literary production throughout several generations of readers which leads to think of their political engagement (SARTRE, 2004) as a powerful tool in formation of an audience. The discussion in this article seeks support in the theory of reception (JAUSS, 2009), stories of literature (MOREIRA, 2002, OLINTO, 2002) and historical writing (BURKE, 1992).Keywords: stories of literature; Reception; Jorge Amado; Pablo Neruda; Nicolás Guillén.
Adaptation and validation of the Hungarian version of the Yale Food Addiction Scale for Children
Authors: Magyar Éva Erzsébet , Tényi Dalma , Gearhardt Ashley , Jeges Sára , Abaligeti Gallusz , Tóth Ákos Levente , Janszky József , Molnár Dénes , Tényi Tamás , Csábi Györgyi 
Published: January 2018

Background
Childhood obesity proves to be an important public health issue, since it serves as a potential risk factor for multiple diseases. Food addiction could also serve as an important etiological factor. As childhood obesity plays a serious issue also in Hungary, we aimed to adapt and validate the Hungarian version of the Yale Food Addiction Scale for Children (H-YFAS-C).

Methods
A total of 191 children were assessed with the H-YFAS-C and the Eating Disorder Inventory (EDI). The following psychometric properties were analyzed: internal consistency, construct validity, convergent, and discriminant validity.

Results
A good construct validity was revealed by confirmatory factor analysis (RMSEA = 0.0528, CFI = 0.896, χ2 value = 279.06). Question 25 proved to have no significant effect on its group and was removed from further analyses. The Kuder–Richardson 20 coefficient indicated good internal consistency (K20 = 0.82). With the use of the eight EDI subscales, a good convergent and discriminant validity could be determined. Food addiction was diagnosed in 8.9% of children. The mean symptom count was 1.7 ± 1.2 (range: 0–7). Females were more often diagnosed with food addiction than males (p = .016; OR = 3.6, 95% CI: 1.2–10.6). BMI percentiles were significantly higher in children with diagnosed food addiction (p = .003). There proved to be no correlation between age and the occurrence of food addiction.

Discussion and conclusion
Our results show that H-YFAS-C is a good and reliable tool for addictive-like behavior assessment.
Meme Manyetik Rezonans Görüntülemede Lezyon Sınırlarının ve Alanının Tespit Edilmesi
Authors: ÇETİNEL Gökçen , GÜL Sevda 
Published: January 2018

Bu çalışmada, meme kanserinin
teşhisinde yaygın olarak kullanılan modalitelerden biri olan MRG sisteminden
elde edilen görüntüler kullanılarak memede oluşan lezyonların sınırlarının
belirlenmesi ve lezyon alanının hesaplanmasına yönelik bir sistem
geliştirilmiştir. Geliştirilen sistem, radyologlara büyük kolaylıklar sağlayan
ve birçok değiştirilebilir seçenek sunan bir ara yüz üzerinden tasarlanmıştır.
Lezyon sınırlarının belirlenmesi ve alanının optimum şekilde hesaplanması için çalışmada
dört farklı yöntemden yararlanılmaktadır. Bu yöntemler, eşikleme tabanlı (Otsu
eşikleme yöntemi), bulanık mantık tabanlı (bulanık c-ortalama (Fuzzy c-means,
FCM)), bölge büyütme tabanlı (Region Growing, RG) ve kümeleme tabanlı (k-ortalama) segmentasyon
yöntemlerdir. Otsu, FCM ve RG yöntemleri tek kanallı gri-seviye bölütleme
yöntemleridir. K-ortalama yöntemi ise,
üç-kanallı renkli görüntüde doğrudan kullanılabilen bir bölütleme yöntemidir.
Segmentasyon adımdan sonra, lezyon alanının hesaplanması için bit-dörtlüsü
(bit-quad) yöntemi uygulanmıştır. Bu aşamalar gerçekleştirildikten sonra geliştirilebilir
bir hastane otomasyon sistemi tasarlanmıştır. Tasarlanan sistem uzmana görsel
olarak farklı seçenekler sunarak meme lezyonlarını birçok yönden inceleme
imkânı sağlamaktadır.