bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart Failure With Improved Ejection Fraction: Clinical Characteristics, Correlates of Recovery, and Survival
Authors: Florea Viorel G. , Rector Thomas S. , Anand Inder S. , Cohn Jay N. 
Published: July 2016

Background—
Heart failure with recovered or improved ejection fraction (HFiEF) has been proposed as a new category of HF. Whether HFiEF is clinically distinct from HF with persistently reduced ejection fraction remains to be validated.

Methods and Results—
Of the 5010 subjects enrolled in the Valsartan Heart Failure Trial (Val-HeFT), 3519 had a baseline left ventricular EF of <35% and a follow-up echocardiographic assessment of EF at 12 months. Of these, 321 (9.1%) patients who had a 12-month EF of >40% constituted the subgroup with HFiEF. EF improved from 28.7±5.6% to 46.5±5.6% in the subgroup with HFiEF and remained reduced (25.2±6.2% and 27.5±7.1%) in the subgroup with HF with reduced ejection fraction. The group with HFiEF had a less severe hemodynamic, biomarker, and neurohormonal profile, and it was treated with a more intense HF medication regimen. Subjects who had higher blood pressure and those treated with a β-blocker or randomized to valsartan had greater odds of being in the HFiEF group, whereas those with an ischemic pathogenesis, a more dilated left ventricle, and a detectable hs-troponin had lower odds of an improvement in EF. Recovery of the EF to >40% was associated with a better survival compared with persistently reduced EF.

Conclusions—
Our data support HFiEF as a stratum of HF with reduced ejection fraction with a more favorable outcome, which occurs in a minority of patients with HF with reduced ejection fraction who have a lower prevalence of ischemic heart disease, a less severe hemodynamic, biomarker, and neurohormonal profile, and who are treated with a more intense HF medication regimen.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00336336.
Cross-border Movement of Patients in the eu: A Re-Appraisal
Authors: Rieder Clemens M. 
Published: July 2016

Abstract
The national welfare state, so it seems, has come under attack by European integration. This article focuses on one facet of the welfare state, that is, healthcare and on one specific dimension, that is, cross-border movement of patients. The institution which has played a pivotal role in the development of the framework regulating the migration of patients is the European Court of Justice (ecj). The Court’s activity in this sensitive area has not remained without critics. This was even more so since the Court invoked Treaty (primary) law which not only has made it difficult to overturn case law but also has left the legislator with very little room for manoeuvre in relation to any future (secondary) eu law. What is therefore of special interest in terms of legitimacy is the legal reasoning by which the Court has made its contribution to the development of this framework. This article is a re-appraisal of the legal development in this field.
The Development and Deployment of a Maintenance Operations Safety Survey
Authors: Langer Marie , Braithwaite Graham R. 
Published: July 2016

Objective: Based on the line operations safety audit (LOSA), two studies were conducted to develop and deploy an equivalent tool for aircraft maintenance: the maintenance operations safety survey (MOSS). Background: Safety in aircraft maintenance is currently measured reactively, based on the number of audit findings, reportable events, incidents, or accidents. Proactive safety tools designed for monitoring routine operations, such as flight data monitoring and LOSA, have been developed predominantly for flight operations. Method: In Study 1, development of MOSS, 12 test peer-to-peer observations were collected to investigate the practicalities of this approach. In Study 2, deployment of MOSS, seven expert observers collected 56 peer-to-peer observations of line maintenance checks at four stations. Narrative data were coded and analyzed according to the threat and error management (TEM) framework. Results: In Study 1, a line check was identified as a suitable unit of observation. Communication and third-party data management were the key factors in gaining maintainer trust. Study 2 identified that on average, maintainers experienced 7.8 threats (operational complexities) and committed 2.5 errors per observation. The majority of threats and errors were inconsequential. Links between specific threats and errors leading to 36 undesired states were established. Conclusion: This research demonstrates that observations of routine maintenance operations are feasible. TEM-based results highlight successful management strategies that maintainers employ on a day-to-day basis. Application: MOSS is a novel approach for safety data collection and analysis. It helps practitioners understand the nature of maintenance errors, promote an informed culture, and support safety management systems in the maintenance domain.
Validity of the Delirium Observation Screening Scale in Identifying Delirium in Home Hospice Patients
Authors: Jorgensen Shea M. , Carnahan Ryan M. , Weckmann Michelle T. 
Published: July 2016

Background: Delirium is common in home hospice patients and conveys significant morbidity to both patients and caregivers. The Delirium Observation Screening Scale (DOS) was developed to improve delirium recognition but has yet to be validated in the home hospice setting. Objective: This pilot study aimed to explore the accuracy of the DOS for identifying delirium in home hospice patients. Design: Prospective delirium evaluation using a convenience sample. Setting/Participants: Community hospice patients were approached for study inclusion. Measurements: Participants were assessed using the Delirium Rating Scale–Revised–98 (DRS-R-98), with results being categorized as “delirium” or “no delirium.” The Delirium Observation Screening Scale scores, completed by hospice nurses during weekly patient assessment visits, were compared to the DRS-R-98 results. Results: Within this population, 30/78 (38%) assessments were categorized as delirious. In the majority of assessments, 69/75 (92%), the DRS-R-98 and DOS provided congruent results. There were 5 false positives and 1 false negative, demonstrating the DOS to be a clinically useful tool with a sensitivity of 0.97 and specificity of 0.89. Conclusion: The DOS appears to be an accurate way to screen for delirium in home hospice patients. Validation of the DOS may help to improve delirium recognition and treatment and has the potential to increase quality of life in this vulnerable population. This input will also be taken into consideration in the development of a systematic screening procedure for delirium diagnosis at our local hospice, which we hope will be generalizable to other hospice agencies.
Not all ultrasounds are created equal: general sonography versus musculoskeletal sonography in the detection of rotator cuff tears
Authors: Cole Brandi , Twibill Kristen , Lam Patrick , Hackett Lisa , Murrell George AC 
Published: July 2016

Background This cross-sectional analytic diagnostic accuracy study was designed to compare the accuracy of ultrasound performed by general sonographers in local radiology practices with ultrasound performed by an experienced musculoskeletal sonographer for the detection of rotator cuff tears. Methods In total, 238 patients undergoing arthroscopy who had previously had an ultrasound performed by both a general sonographer and a specialist musculoskeletal sonographer made up the study cohort. Accuracy of diagnosis was compared with the findings at arthroscopy. Results When analyzed as all tears versus no tears, musculoskeletal sonography had an accuracy of 97%, a sensitivity of 97% and a specificity of 95%, whereas general sonography had an accuracy of 91%, a sensitivity of 91% and a specificity of 86%. When the partial tears were split with those ≥ 50% thickness in the tear group and those < 50% thickness in the no-tear group, musculoskeletal sonography had an accuracy of 97%, a sensitivity of 97% and a specificity of 100% and general sonography had an accuracy of 85%, a sensitivity of 84% and a specificity of 87%. Conclusions Ultrasound in the hands of an experienced musculoskeletal sonographer is highly accurate for the diagnosis of rotator cuff tears. General sonography has improved subsequent to earlier studies but remains inferior to an ultrasound performed by a musculoskeletal sonographer.
Radiographic Assessment of a Medullary Total Ankle Prosthesis
Authors: Prissel Mark A. , Berlet Gregory C. , Scott Ryan T. , Daigre Justin L. , Bull Patrick E. , Peterson Kyle S. , Collins Christy L. , Hyer Christopher F. 
Published: July 2016

Total ankle replacement (TAR) is a viable alternative to ankle fusion in certain patients with end-stage ankle arthritis. Despite the importance of understanding alignment and movement of the prosthesis, there is no standardized radiographic method for evaluating the position and movement of the INBONE 2 prosthesis. The aims of this study were to describe a radiographic measurement protocol for INBONE 2 for clinical practice and research while determining the interobserver and intraobserver reliability using standard weightbearing radiographs. Fifteen patients were randomly selected with operative dates from January 2011 to January 2014 who underwent primary TAR using the INBONE 2 prosthesis. Most recent preoperative and first postoperative weightbearing anteroposterior and lateral radiographs were pulled and deidentified. Three foot and ankle surgeons blinded from the patient selection and deidentification, measured the described measurements on separate occasions. Intraobserver reliability: surgeon 1 had acceptable reliability for 9 of 13 continuous radiographic measurements (69.2%), surgeon 2 had acceptable reliability for 8 of 13 measurements (61.5%), and surgeon 3 had acceptable reliability for 12 of 13 measurements (92.3%). Interobserver reliability: among the first measurements, 6 of 13 continuous radiographic measurements (46.2%) had acceptable reliability. Among the second measurements, 7 of 13 measurements (53.8%) had acceptable reliability. Among the first and second measurements combined, 7 of 13 measurements (53.8%) had acceptable reliability. This study promotes the need for meticulous evaluation of annual radiographic findings following TAR in an effort to avoid catastrophic failure and represents moderate agreement can be obtained by employing the proposed measurements for surveillance of INBONE 2 TAR at annual postoperative visits. Measurements on the anteroposterior radiograph appear to demonstrate more consistent results for surveillance than lateral measurements. The intraobserver reliability results were somewhat superior to the interobserver reliability, implying more relevance for a single surgeon applying these measurements annually for postoperative surveillance. Levels of Evidence: Diagnostic, Level III
Rationale and design of the Kanyini guidelines adherence with the polypill (Kanyini-GAP) study: a randomised controlled trial of a polypill-based strategy amongst Indigenous and non Indigenous people at high cardiovascular risk
Authors: Liu Hueiming , Patel Anushka , Brown Alex , Eades Sandra , Hayman Noel , Jan Stephen , Ring Ian , Stewart Greg , Tonkin Andrew , Weeramanthri Tarun , Wade Vicki , Rodgers Anthony , Usherwood Tim , Neal Bruce , Peiris David , Burke Hugh , Reid Christopher , Cass Alan ,   the Kanyini Vascular Collaboration and Kanyini GAP Study Team
Published: July 2016

Abstract

Background
The Kanyini Guidelines Adherence with the Polypill (Kanyini-GAP) Study aims to examine whether a polypill-based strategy (using a single capsule containing aspirin, a statin and two blood pressure-lowering agents) amongst Indigenous and non-Indigenous people at high risk of experiencing a cardiovascular event will improve adherence to guideline-indicated therapies, and lower blood pressure and cholesterol levels.

Methods/Design
The study is an open, randomised, controlled, multi-centre trial involving 1000 participants at high risk of cardiovascular events recruited from mainstream general practices and Aboriginal Medical Services, followed for an average of 18 months. The participants will be randomised to one of two versions of the polypill, the version chosen by the treating health professional according to clinical features of the patient, or to usual care. The primary study outcomes will be changes, from baseline measures, in serum cholesterol and systolic blood pressure and self-reported current use of aspirin, a statin and at least two blood pressure lowering agents. Secondary study outcomes include cardiovascular events, renal outcomes, self-reported barriers to indicated therapy, prescription of indicated therapy, occurrence of serious adverse events and changes in quality-of-life. The trial will be supplemented by formal economic and process evaluations.

Discussion
The Kanyini-GAP trial will provide new evidence as to whether or not a polypill-based strategy improves adherence to effective cardiovascular medications amongst individuals in whom these treatments are indicated.

Trial Registration
This trial is registered with the Australian New Zealand Clinical Trial Registry ACTRN126080005833347.
Using principal component analysis to develop a single-parameter screening tool for metabolic syndrome
Authors: Chang Chia-Hao , Yen Ching-Ho , Chen Mei-Yen 
Published: July 2016

Abstract

Background
Metabolic syndrome (MS) is an important current public health problem faced worldwide. To prevent an "epidemic" of this syndrome, it is important to develop an easy single-parameter screening technique (such as waist circumference (WC) determination recommended by the International Diabetes Federation). Previous studies proved that age is a chief factor corresponding to central obesity. We intended to present a new index based on the linear combination of body mass index, and age, which could enhance the area under the receiver operating characteristic curves (AUCs) for assessing the risk of MS.

Methods
The labour law of the Association of Labor Standard Law, Taiwan, states that employers and employees are respectively obligated to offer and receive routine health examination periodically. Secondary data analysis and subject's biomarkers among five high-tech factories were used in this study between 2007 and 2008 in northern Taiwan. The subjects included 4712 males and 4196 females. The first principal component score (FPCS) and equal-weighted average (EWA) were determined by statistical analysis.

Results
Most of the metabolic and clinical characteristics were significantly higher in males than in females, except high-density lipoprotein cholesterol level. The older group (>45 years) had significantly lower values for height and high-density lipoprotein cholesterol level than the younger group. The AUCs of FPCS and EWA were significantly larger than those of WC and waist-to-height ratio. The low specificities of EWA and FPCS were compensated for by their substantially high sensitivities. FPCS ≥ 0.914 (15.4%) and EWA ≥ 8.8 (6.3%) were found to be the most prevalent cut off points in males and females, respectively.

Conclusions
The Bureau of Health Promotion, Department of Health, Taiwan, had recommended the use of WC ≥ 90 cm for males and ≥ 80 cm for females as singular criteria for the determination of central obesity instead of multiple parameters. The present investigation suggests that FPCS or EWA is a good predictor of MS among the Taiwanese. However, the use of FPCS is not computationally feasible in practice. Therefore, we suggest that EWA be used in clinical practice as a simple parameter for the identification of those at risk of MS.
Worksite health screening programs for predicting the development of Metabolic Syndrome in middle-aged employees: a five-year follow-up study
Authors: Lin Yu-Cheng , Chen Jong-Dar , Lo Su-Huey , Chen Pau-Chung 
Published: July 2016

Abstract

Background
Metabolic syndrome (MetS) management programs conventionally focus on the adults having MetS. However, risk assessment for MetS development is also important for many adults potentially at risk but do not yet fulfill MetS criteria at screening. Therefore, we conducted this follow-up study to explore whether initial screening records can be efficiently applied on the prediction of the MetS occurrence in healthy middle-aged employees.

Methods
Utilizing health examination data, a five-year follow-up observational study was conducted for 1384 middle-aged Taiwanese employees not fulfilling MetS criteria. Data analyzed included: gender, age, MetS components, uric acid, insulin, liver enzymes, sonographic fatty liver, hepatovirus infections and lifestyle factors. Multivariate logistic regression was used to estimate the adjusted odds ratios (OR) and 95% confidence interval (CI) of risk for MetS development. The synergistic index (SI) values and their confidence intervals of risk factor combinations were calculated; and were used to estimate the interacting effects of coupling MetS components on MetS development.

Results
Within five years, 13% (175 out of 1384) participants fulfilled MetS criteria. The ORs for MetS development among adults initially having one or two MetS components were 2.8 and 7.3, respectively (both p < 0.01), versus the adults having zero MetS component count at screening. Central obesity carried an OR of 7.5 (p < 0.01), which far exceeded other risk factors (all ORs < 2.7). Synergistic effects on MetS development existed between coupling MetS components: 1. High blood pressure plus low-HDL demonstrated an OR of 11.7 (p < 0.01) for MetS development and an SI of 4.7 (95% CI, 2.1-10.9). 2. High blood pressure plus hyperglycemia had an OR of 7.9 (p < 0.01), and an SI of 2.7 (95% CI, 1.2-6.4).

Conclusion
MetS component count and combination can be used in predicting MetS development for participants potentially at risk. Worksite MetS screening programs simultaneously allow for finding out cases and for assessing risk of MetS development.
Higher Prices for Larger Quantities? Nonmonotonic Price–Quantity Relations in B2B Markets
Authors: Zhang Wei , Dasu Sriram , Ahmadi Reza 
Published: July 2016

We study a microprocessor company selling short-life-cycle products to a set of buyers that includes large consumer electronic goods manufacturers. The seller has a limited capacity for each product and negotiates with each buyer for the price. Our analysis of their sales data reveals that larger purchases do not always result in bigger discounts. Instead, the discount curve is like an “N.” While existing theories cannot explain this nonmonotonic pattern, we develop an analytical model and show that the nonmonotonicity is rooted in how sellers value capacity when negotiating with a buyer. Large buyers accelerate the selling process and small buyers are helpful in consuming the residual capacity. However, satisfying midsized buyers may be costly because supplying these buyers can make it difficult to utilize the remaining capacity, which is often too much for small buyers but not enough for large buyers. We briefly discuss the implications for capacity rationing and posted pricing as well as potential applications to other industries. This paper was accepted by Serguei Netessine, operations management.
Between First- and Second-Order Stochastic Dominance
Authors: Müller Alfred , Scarsini Marco , Tsetlin Ilia , Winkler Robert L. 
Published: July 2016

We develop a continuum of stochastic dominance rules, covering preferences from first- to second-order stochastic dominance. The motivation for such a continuum is that while decision makers have a preference for “more is better,” they are mostly risk averse but cannot assert that they would dislike any risk. For example, situations with targets, aspiration levels, and local convexities in induced utility functions in sequential decision problems may lead to preferences for some risks. We relate our continuum of stochastic dominance rules to utility classes, the corresponding integral conditions, and probability transfers and discuss the usefulness of these interpretations. Several examples involving, e.g., finite-crossing cumulative distribution functions, location-scale families, and induced utility, illustrate the implementation of the framework developed here. Finally, we extend our results to a combined order including convex (risk-taking) stochastic dominance. This paper was accepted by Manel Baucells, decision analysis.
“A Symbol of His Warmth and Humanity”: Fala, Roosevelt, and the Personable Presidency
Authors: Blankfield Bryan 
Published: July 2016

Abstract
This article examines how rhetoric about Franklin Delano Roosevelt’s Scottish terrier, Fala, contributed to the president’s public image. I argue that Fala’s presence further enhanced FDR’s more personable presidency by highlighting the president’s warmth and humanity. To demonstrate this claim, I perform a close textual analysis of archival evidence from the FDR Presidential Library and two Metro-Goldwyn-Mayer shorts. Presidential pets thus provide presidents with important sources for fashioning their public image.
Rosie’s Secret Identity, Or, How to Debunk a Woozle by Walking Backward through the Forest of Visual Rhetoric
Authors: Kimble James J. 
Published: July 2016

Abstract
This essay investigates the authenticity of Geraldine Hoff Doyle’s widely accepted status as the model for the World War II–era “We Can Do It!” poster. After considering the rhetorical nature of the so-called woozle effect, the analysis endeavors to counter this particular woozle by plotting a reverse narrative. Taking the form of a quest that moves backward through a metaphorical forest of visual rhetoric, the essay initially traces the sources of Doyle’s tale into the recent past and, subsequently, into the original visual context. At length, it debunks Doyle’s claim while identifying Naomi Parker as a previously unknown figure in the controversy surrounding the poster.
Framed curves in the Euclidean space
Authors: Honda Shun’ichi , Takahashi Masatomo 
Published: July 2016

Abstract
A framed curve in the Euclidean space is a curve with a moving frame. It is a generalization not only of regular curves with linear independent condition, but also of Legendre curves in the unit tangent bundle. We define smooth functions for a framed curve, called the curvature of the framed curve, similarly to the curvature of a regular curve and of a Legendre curve. Framed curves may have singularities. The curvature of the framed curve is quite useful to analyse the framed curves and their singularities. In fact, we give the existence and the uniqueness for the framed curves by using their curvature. As applications, we consider a contact between framed curves, and give a relationship between projections of framed space curves and Legendre curves.