bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trans-generational desensitization and within-generational resensitization of a sucrose-best neuron in the polyphagous herbivore Helicoverpa armigera (Lepidoptera: Noctuidae)
Authors: Ma Ying , Li Jingjing , Tang Qingbo , Zhang Xuening , Zhao Xincheng , Yan Fengming , van Loon Joop J. A. 
Published: December 2016

AbstractDietary exposure of insects to a feeding deterrent substance for hours to days can induce habituation and concomitant desensitization of the response of peripheral gustatory neurons to such a substance. In the present study, larvae of the herbivoreHelicoverpa armigerawere fed on diets containing either a high, medium or low concentration of sucrose, a major feeding stimulant. The responsiveness of the sucrose-best neuron in the lateral sensilla styloconica on the galea was quantified. Results showed the response of the sucrose-best neuron exposed to high-sucrose diets decreased gradually over successive generations, resulting in complete desensitization in the 5thand subsequent generations. However, the sensitivity was completely restored in the ninth generation after neonate larvae were exposed to low-sucrose diet. These findings demonstrate phenotypic plasticity and exclude inadvertent artificial selection for low sensitivity to sucrose. No significant changes were found in the sensitivity of caterpillars which experienced low- or medium-sucrose diets over the same generations. Such desensitization versus re-sensitization did not generalise to the phagosimulantmyo-inositol-sensitive neuron or the feeding deterrent-sensitive neuron. Our results demonstrate that under conditions of high sucrose availability trans-generational desensitization of a neuron sensitive to this feeding stimulant becomes more pronounced whereas re-sensitization occurs within one generation.
Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies
Authors: Zafra Francisco , Ibáñez Ignacio , Giménez Cecilio 
Published: December 2016

Glycinergic neurons are major contributors to the regulation of neuronal excitability, mainly in caudal areas of the nervous system. These neurons control fluxes of sensory information between the periphery and the CNS and diverse motor activities like locomotion, respiration or vocalization. The phenotype of a glycinergic neuron is determined by the expression of at least two proteins: GlyT2, a plasma membrane transporter of glycine, and VIAAT, a vesicular transporter shared by glycine and GABA. In this article, we review recent advances in understanding the role of GlyT2 in the pathophysiology of inhibitory glycinergic neurotransmission. GlyT2 mutations are associated to decreased glycinergic function that results in a rare movement disease termed hyperekplexia (HPX) or startle disease. In addition, glycinergic neurons control pain transmission in the dorsal spinal cord and their function is reduced in chronic pain states. A moderate inhibition of GlyT2 may potentiate glycinergic inhibition and constitutes an attractive target for pharmacological intervention against these devastating conditions.
Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries
Authors: Nam Dong Hyun , Rodriguez Carlos , Remacle Albert G. , Strongin Alex Y. , Ge Xin 
Published: December 2016

SignificanceThe matrix metalloproteinase (MMP) family members are promising drug targets in diversified pathologies. Clinical trial failures taught us that selective, rather than broad-specificity, inhibitors are required for successful MMP therapies. Achieving target selectivity with small-molecule MMP inhibitors, however, is exceedingly difficult. Because the antigen-binding sites in conventional antibodies are predominantly incompatible with the concave reaction pockets of MMPs, design of inhibitory antibodies, an attractive alternative for selective inhibition, is also challenging. We synthesized human antibody libraries encoding extended convex antigen-binding sites and isolated a panel of inhibitory Fabs that selectively and efficiently inhibited MMP-14, a promising drug target in cancer. The pipeline we established can now be readily applied for the generation of inhibitory antibodies targeting multiple additional enzymes besides MMPs alone.
Dutch impersonal passives
Authors: Beliën Maaike 
Published: December 2016

Abstract
Dutch impersonal passives are often considered to be only compatible with atelic volitional verbs, such as werken ‘work’, lachen ‘laugh’, and zwemmen ‘swim’. Two recent corpus studies, however, argue that a wider range of verbs is compatible with the construction, presenting examples of attested impersonal passives with telic and non-volitional verbs. This paper lends further support to this view, by providing an exploratory study of the frequencies of different intransitive verbs appearing in the construction, as well as a discussion of the telicity of attested impersonal passives with vallen ‘fall’ and sterven ‘die’. The paper concludes that also with these telic non-volitional verbs, the impersonal passive merely conveys the occurrence of the type of act described by the verb, without specifying whether this occurrence is constituted by a single or multiple events, or whether it involves one or more participants.
Imperatives and politeness in Dutch
Authors: Hoop Helen de , Klatter Jetske , Mulder Gijs , Schmitz Tijn 
Published: December 2016

Abstract
Imperatives are usually thought of as direct and therefore impolite. However, imperatives such as Have some coffee, Enjoy your holiday, or Sleep well are not considered impolite. The reason seems to be that these imperatives refer to actions that are beneficial to the hearer only. We make a distinction between two types of imperatives, those referring to actions that are beneficial to the speaker and those that are beneficial to the hearer. We have conducted an experiment in order to examine the relation between the two types of imperatives and how they are perceived by speakers of Dutch. The results show that there is indeed a significant difference in interpretation between the two types of imperatives in Dutch. In addition, we have tested the effects of adding a politeness marker alsjeblieft ‘please’ or discourse particles to the imperatives.
Deriving verb-cluster variation in Dutch and German
Authors: Kampen Jacqueline van 
Published: December 2016

Abstract
The difference in West-Germanic V(erb)-clusters, right-branching (Dutch) and left-branching (German), follows from a difference in the acquisition of V-second. The decisive factor is a rightward selection of the <+Aux> verbs in Dutch main clauses. That decisive factor had already been acquired before any V-cluster appeared in the child’s speech. Longitudinal Dutch child data show that modals and aspectuals develop a rightward selection that carries over into the V-cluster. The German child data do not show such a development. Automatic phrasal formation by the acquisition procedure allows a V-cluster without assuming V-to-V-movement from an underlying structure. The general perspective is that (i) the acquisition procedure is a discovery procedure, and that (ii) typological effects are the outcome of early local string-determined licensing/selection.
The influence of L2 English and immersion education on L3 French in the Netherlands
Authors: Stadt Rosalinde , Hulk Aafke , Sleeman Petra 
Published: December 2016

Abstract
In this paper, we test the L2 Status Factor (Bardel & Falk, 2007) by examining to what extent Dutch secondary school students (13–15 years) prefer L2 English over L1 Dutch in L3 French acquisition, and we study the influence of L2 education by comparing an English immersion curriculum vs. a regular Dutch curriculum. We investigate verb placement in declarative root clauses, viz. V-to-T movement, where the finite verb moves to T in French but not in English and V-to-C movement, in which the V2-rule applies in Dutch but not in French. We report data from a Grammaticality Judgement Task. The results indicate that in the immersion group there is significantly more influence from English than from Dutch. In the regular group, the L1 and the L2 are both important sources of transfer.
Definedness conditions on admission-of-ignorance moves
Authors: Vicente Luis 
Published: December 2016

Abstract
Given a set of alternatives, a speaker can explicitly admit ignorance about which of them hold true. The (in)felicity of such admission-of-ignorance moves immediately following disjunctions and conjunctions follows from the semantics of or and and. However, semantics alone turns out to be insufficient in cases when the disjunction/conjunction and the admission-of-ignorance move are separated by additional conversational moves of acceptance, objection, or removal of an existing assertion. I argue that these patterns follow if admission-of-ignorance are associated to a speech act operator admit whose input is restricted to propositions that the current speaker is publicly committed to at the current conversational stage.
Bilateral comparison of 1 Ω and 10 kΩ standards (ongoing BIPM key comparisons BIPM.EM-K13.a and 13.b) between the BIM (Bulgaria) and the BIPM
Authors: Rolland B , Fletcher N , Tenev A , Hadzhistoykova R 
Published: December 2016

This report gives the result of a bilateral comparison of resistance between the BIM (Bulgaria) and the BIPM carried out in 2013. Two 1 Ω and two 10 kΩ travelling standards belonging to the BIPM were used. The comparison was carried out with an 'A-B-A' pattern of measurements; the standards were measured first at the BIPM for a period of about one month, then for a similar period at the BIM, and finally again at the BIPM. The measurand was the 4 terminal dc resistance at low power. The BIPM was the pilot laboratory, and the comparison forms part of the ongoing BIPM key comparisons BIPM.EM-K13.a (for 1 Ω) and BIPM.EM-K13b (for 10 kΩ).
The results from the BIM and the BIPM were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95% confidence, k = 2) of 0.30 × 10-6 at 10 kΩ and in reasonable agreement for 1 Ω with a relative difference of -0.18 × 10-6 with a relative expanded uncertainty of 0.17 × 10-6.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Bilateral comparison of 1 Ω and 10 kΩ standards (ongoing BIPM key comparisons BIPM.EM-K13.a and 13.b) between the NIMT (Thailand) and the BIPM
Authors: Rolland B , Fletcher N , Khumthukthit N , Jassadajin C 
Published: December 2016

This report gives the result of a bilateral comparison of resistance between the NIMT (Thailand) and the BIPM carried out in 2015. Two 1 Ω and two 10 kΩ travelling standards belonging to the BIPM were used. The comparison was carried out with an 'A-B-A' pattern of measurements; the standards were measured first at the BIPM for a period of about one month, then for a similar period at the BIM, and finally again at the BIPM. The measurand was the 4 terminal dc resistance at low power. The BIPM was the pilot laboratory, and the comparison forms part of the ongoing BIPM key comparisons BIPM.EM-K13.a (for 1 Ω) and BIPM.EM-K13b (for 10 kΩ).
The results from the NIMT and the BIPM were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95% confidence, k = 2) of 0.20 × 10-6 for 1 Ω and 0.74 × 10-6 for 10 kΩ.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Final report on the key comparison, CCM.P-K15 in the pressure range from 1.0 × 10-4 Pa to 1.0 Pa
Authors: Wuethrich Christian , Arai Kenta , Bergoglio Mercede , Fedchak James A , Jousten Karl , Hong Seung Soo , Guzman Jorge Torres 
Published: December 2016

The comparison CCM.P-K15 is a key comparison in pressure involving six laboratories in three regional metrological organizations (RMO). The measurand of the comparison is the accommodation coefficient of two spinning rotating gauge characterized in nitrogen from 0.1 mPa up to 1.0 Pa. The two transfer standards were circulated from November 2009 until March 2011. The circulation consisted of three loops, one for each RMO, and a new calibration by the pilot be-tween each loop. The stability of one of the transfer standards was poor and was worse than expected based on the previous history of the transfer standard while the other transfer standard demonstrated good stability while circulated in Europe and America and a fair stability while circulated in Asia.
All the participants demonstrated equivalence to the definition of pressure in their respective primary standards.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Research and development of artificial intelligence in China
Authors: Qiu Jane 
Published: December 2016

Abstract
This year saw several milestones in the development of artificial intelligence. In March, AlphaGo, a computer algorithm developed by Google's London-based company, DeepMind, beat the world champion Lee Sedol at Go, an ancient Chinese board game. In October, the same company unveiled in the journal Nature its latest technique that allows a machine to solve tasks that require logic and reasoning, such as finding its way around the London Underground using a map it has never seen before.
Such progress in recent years has provided significant impetus to developing cutting-edge learning machines around the world, including China. In 2015, the Chinese Academy of Sciences (CAS) set up the Centre for Excellence in Brain Science and Intelligence Technology—a consortium of laboratories from more than 20 CAS institutes and universities. Early this year, China rolled out the China Brain Project, a fifteen-year programme that will focus on brain mapping, neurological diseases and brain-inspired artificial intelligence.
In a forum chaired by National Science Review's Executive Associative Editor, Mu-ming Poo, who also leads the CAS centre for excellence and the China Brain Project, several researchers discussed China's latest initiatives and progress in artificial intelligence, where the future lies and what the main challenges are.

Yunji Chen
Institute of Computing Technology, Chinese Academy of Sciences, Beijing

Tieniu Tan
Institute of Automation, Deputy President of Chinese Academy of Sciences, Beijing

Yi Zeng
Institute of Automation, Chinese Academy of Sciences, Beijing

Hongbin Zha
Director of Key Lab of Machine Perception (MOE), Peking University, Beijing

Mu-ming Poo (Chair)
Director of Institute of Neuroscience, Chinese Academy of Sciences, Shanghai
Faculty–Resident “Co-learning”: A Longitudinal Exploration of an Innovative Model for Faculty Development in Quality Improvement
Authors: Wong Brian M. , Goldman Joanne , Goguen Jeannette M. , Base Christian , Rotteau Leahora , Van Melle Elaine , Kuper Ayelet , Shojania Kaveh G. 
Published: December 2016

Purpose
To examine the effectiveness of co-learning, wherein faculty and trainees learn together, as a novel approach for building quality improvement (QI) faculty capacity.

Method
From July 2012 through September 2015, the authors conducted 30 semistructured interviews with 23 faculty participants from the Co-Learning QI Curriculum of the Department of Medicine, Faculty of Medicine, University of Toronto, and collected descriptive data on faculty participation and resident evaluations of teaching effectiveness. Interviewees were from 13 subspecialty residency programs at their institution.

Results
Of the 56 faculty participants, the Co-Learning QI Curriculum trained 29 faculty mentors, 14 of whom taught formally. Faculty leads with an academic QI role, many of whom had prior QI training, reinforced their QI knowledge while also developing QI mentorship and teaching skills. Co-learning elements that contributed to QI teaching skills development included seeing first how the QI content is taught, learning through project mentorship, building experience longitudinally over time, a graded transition toward independent teaching, and a supportive program lead. Faculty with limited QI experience reported improved QI knowledge, skills, and project facilitation but were ambivalent about assuming a teacher role. Unplanned outcomes for both groups included QI teaching outside of the curriculum, applying QI principles to other work, networking, and strengthening one’s QI professional role.

Conclusions
The Co-Learning QI Curriculum was effective in improving faculty QI knowledge and skills and increased faculty capacity to teach and mentor QI. Findings suggest that a combination of curriculum and contextual factors were critical to realizing the curriculum’s full potential.
Constructing a Shared Mental Model for Faculty Development for the Core Entrustable Professional Activities for Entering Residency
Authors: Favreau Michele A. , Tewksbury Linda , Lupi Carla , Cutrer William B. , Jokela Janet A. , Yarris Lalena M. 
Published: December 2016

In 2014, the Association of American Medical Colleges identified 13 Core Entrustable Professional Activities for Entering Residency (Core EPAs), which are activities that entering residents might be expected to perform without direct supervision. This work included the creation of an interinstitutional concept group focused on faculty development efforts, as the processes and tools for teaching and assessing entrustability in undergraduate medical education (UME) are still evolving. In this article, the authors describe a conceptual framework for entrustment that they developed to better prepare all educators involved in entrustment decision making in UME. This framework applies to faculty with limited or longitudinal contact with medical students and to those who contribute to entrustment development or render summative entrustment decisions.
The authors describe a shared mental model for entrustment that they developed, based on a critical synthesis of the EPA literature, to serve as a guide for UME faculty development efforts. This model includes four dimensions for Core EPA faculty development: (1) observation skills in authentic settings (workplace-based assessments), (2) coaching and feedback skills, (3) self-assessment and reflection skills, and (4) peer guidance skills developed through a community of practice. These dimensions form a conceptual foundation for meaningful faculty participation in entrustment decision making.
The authors also differentiate between the UME learning environment and the graduate medical education learning environment to highlight distinct challenges and opportunities for faculty development in UME settings. They conclude with recommendations and research questions for future Core EPA faculty development efforts.
The Early Tech Development Course: Experiential Commercialization Education for the Medical Academician
Authors: Servoss Jonathan , Chang Connie , Fay Jonathan , Ward Kevin 
Published: December 2016

Problem
Research produced by medical academicians holds promise for developing into biomedical innovations in therapeutics, devices, diagnostics, and health care information technology; however, the road to biomedical innovation is fraught with risk, including the challenge of moving from basic research insight onto a viable commercialization path. Compounding this challenge is the growing demand on medical academicians to be more productive in their clinical, teaching, and research duties within a resource-constrained environment.

Approach
In 2014, the University of Michigan (UM) Medical School and College of Engineering codesigned and implemented an accelerated, biomedical-focused version of the National Science Foundation (NSF) Innovation Corps (I-Corps) program. The UM Early Tech Development (ETD) Course, designed for medical academicians exploring the commercial potential of early-stage ideas, covers the NSF I-Corps concept; supports the formation of teams of faculty, graduate, and medical students; and accommodates medical academicians’ schedules.

Outcomes
From 2014 to 2015, the ETD Course graduated 39 project teams from UM and other institutions. One-third of the teams have continued to pursue their projects, receiving additional funding, engaging industry partners, or enrolling in the NSF I-Corps program.

Next Steps
The ETD Course, a potential pipeline to the NSF I-Corps program, captures a target audience of medical academicians and others in academic medicine. To better understand the long-term effects of the course and its relationship to the NSF I-Corps program, the authors will conduct a study on the careers of all ETD Course graduates, including those who have enrolled in NSF I-Corps versus those who have not.
Sensory Symptom Profiles of Patients With Neuropathic Pain After Spinal Cord Injury
Authors: Soler Maria Dolors , Moriña David , Rodríguez Neus , Saurí Joan , Vidal Joan , Navarro Albert , Navarro Xavier 
Published: December 2016

Aim:
Individuals experiencing neuropathic pain (NP) after spinal cord injury (SCI) present with a variety of pain descriptors in different combinations and at different intensities. These sensory features form distinct patterns, known as sensory symptom profiles.

Methods:
In the present cross-sectional study, we have used a multivariate statistical method (multiple correspondence analysis) to categorize the sensory symptom profiles of a cohort of 338 patients with at-level or below-level NP after SCI. We also investigated possible associations between positive neuropathic symptoms and features of the neurological lesion.

Results:
The majority of participants had a combination of pain descriptors, with 59% presenting with 3 or 4 pain subtypes. No significant associations were found between specific pain profiles and etiology or clinical degree of the neurological lesion. Furthermore, similar symptom profiles were seen in patients with at-level and below-level NP. The most frequent pattern observed in patients with cervical SCI consisted predominantly of electric shocks and tingling, without burning, pressure pain, or allodynia.

Conclusions:
Classification of SCI-NP patients into the 5 groups identified in the present study based on their distinct sensory symptom profiles may allow identification of those most likely to respond to a specific analgesic approach.