bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of body composition with bioimpedence. A comparison between athletic and non‐athletic children
Authors: Meleleo Domenico , Bartolomeo Nicola , Cassano Liliana , Nitti Alessandro , Susca Giovanna , Mastrototaro Giuseppina , Armenise Umberto , Zito Annapaola , Devito Fiorella , Scicchitano Pietro , Ciccone Marco Matteo 
Published: March 2017

AbstractPurpose: Conventional Bioelectrical Impedance Analysis (BIA) or Bioelectrical Impedance Vector Analysis (BIVA) can provide direct evaluations of body composition. The purpose of this study was to evaluate lean and fat mass (FM), and hydration of children involved in daily competitive sports. Methods: 190 non‐athletic [8.2–10.5 years] and 29 competitive children [8.0–10.5 years] were enrolled. They were evaluated: at baseline (t0), 6 months (t1) and one year (t2). Anthropometric, BIA and BIVA, lean and FM, and hydration evaluations were performed. Results: Resistance (R/h) and reactance (Xc/h) were lower at t0 in competitive individuals when compared to controls. Xc/h (+3.28) significantly increases in competitive when compared to non‐competitive individuals (+0.66, p for difference: 0.011), while phase angle (PA) was lower at t0 (5.72 vs. 6.17, p < .001) and after 6 months (p = .001). Total body water adjusted for height (TBW/h) significantly increased only in non‐athletes (+0.50 ± 0.13, p < .001) between t0 and t1. At t1, extracellular water (ECW) significantly decreased (p = .026) in the two groups: −0.45 ± 0.19% in non‐competitive, −1.63 ± 0.49% in competitive subjects, while intracellular water (ICW) increased. At one‐year follow‐up (t2), there were no statistically significant differences in R/h, Xc/h and PA in competitive individuals when compared to baseline and t1. Furthermore, we observed at t2 that hours/week of training, age, male gender and body mass index can influence FFM/h and FM/h in both competitive and non‐competitive subjects. In particular, a direct correlation was for hours/week and FFM/h, inverse for hours/week and FM/h. Conclusions: Body mass index does not allow evaluating differences in lean body mass and FM between athletes and non‐athletes. BIA and BIVA can give more reliable details about body composition differences in competitive adolescents and non‐competitive, outlining a progressive decline in ECW and increase in ICW without affecting TBW composition of athletes.
Aozan: an automated post-sequencing data-processing pipeline
Authors: Perrin Sandrine , Firmo Cyril , Lemoine Sophie , Le Crom Stéphane , Jourdren Laurent 
Published: March 2017

Abstract

Motivation
Data management and quality control of output from Illumina sequencers is a disk space- and time-consuming task. Thus, we developed Aozan to automatically handle data transfer, demultiplexing, conversion and quality control once a run has finished. This software greatly improves run data management and the monitoring of run statistics via automatic emails and HTML web reports.

Availability and Implementation
Aozan is implemented in Java and Python, supported on Linux systems, and distributed under the GPLv3 License at: http://www.outils.genomique.biologie.ens.fr/aozan/. Aozan source code is available on GitHub: https://github.com/GenomicParisCentre/aozan.
Trends in the Purchase of Surgical Care in the Community by the Veterans Health Administration
Authors: Rosen Amy K. , O’Brien William , Chen Qi , Shwartz Michael , Itani Kamal F.M. , Gunnar William 
Published: March 2017

Background:
The 2014 implementation of the Veterans Choice Program increased opportunities for Veterans to receive care in the community. Although surgical care is a Veterans Health Administration (VHA) priority, little is known about the types of surgeries provided in the VHA versus those referred to community care (CC), and whether Veterans are increasing their use of surgical care through CC with these additional opportunities.

Objectives:
To examine national trends across VHA facilities in the frequencies and types of surgeries provided in the VHA and through CC, and explore the association between facilities’ purchase of care with rurality and surgical complexity designation.

Research Design:
Retrospective study using Veterans Administration (VA) outpatient and CC data from the VA’s Corporate Data Warehouse (October 1, 2013–September 30, 2016).

Measures:
Veterans’ demographics, outpatient surgeries, facility rurality, and surgical complexity.

Results:
Our sample included 525,283 outpatient surgeries; 79% occurred in the VHA over the study timeframe. The proportion of CC surgeries increased from 16% in October 2013 to 29% in December 2014, and then subsequently declined, leveling off at 21% in June 2016 (trend, P<0.05). These trends varied by surgery type. Increases in CC surgeries were evident for 4 surgery types: cardiovascular, digestive, eye and ocular, and male genital surgeries (all trends, P<0.05). Rural and low-complexity facilities were more likely to purchase surgical CC than their urban and high-complexity counterparts (P<0.0001).

Conclusions:
Although the VHA remains the primary provider of surgical care for Veterans, Veterans Choice Program implementation increased Veterans’ use of CC relative to the VHA for certain types of surgeries, potentially bringing challenges to the VHA in delivering and coordinating surgical care across settings.
Translating biomarkers from research to clinical use in pediatric neurocritical care: focus on traumatic brain injury and cardiac arrest
Authors: Prout Andrew J. , Wolf Michael S. , Fink Ericka L. 
Published: March 2017

Purpose of review
Traumatic brain injury (TBI) and cardiac arrest are important causes of morbidity and mortality in children. Improved diagnosis and outcome prognostication using validated biomarkers could allow clinicians to better tailor therapies for optimal efficacy.

Recent findings
Contemporary investigation has yielded plentiful biomarker candidates of central nervous system (CNS) injury, including macromolecules, genetic, inflammatory, oxidative, and metabolic biomarkers. Biomarkers have yet to be validated and translated into bedside point-of-care or cost-effective and efficient laboratory tests. Validation testing should consider developmental status, injury mechanism, and time trajectory with patient-centered outcomes.

Summary
Recent investigation of biomarkers of CNS injury may soon improve diagnosis, management, and prognostication in children with traumatic brain injury and cardiac arrest.
Autogenic Drainage in Children With Cystic Fibrosis
Authors: Corten Lieselotte , Morrow Brenda M. 
Published: March 2017

Purpose:
Airway clearance is an essential part of the management of cystic fibrosis (CF) as it facilitates clearance of viscous pulmonary secretions. This review aimed to determine the effect of autogenic drainage (AD) and assisted autogenic drainage (AAD) compared with no, sham, or other types of airway clearance in children with CF.

Summary of Key Points:
Two pediatric randomized cross-over trials were identified on the use of AD in children with CF; no studies were available on the use of AAD. In one study AD had a positive influence on the Huang score, and is preferred over postural drainage in this population.

Conclusions and Recommendations:
We could not determine the efficacy of AD and AAD in children with CF. We recommend the implementation of pediatric-specific randomized controlled trials with adequate sample sizes, appropriate clinical outcome measures, and analysis of adverse effects.
Focused and Corrective Feedback Versus Structured and Supported Debriefing in a Simulation-Based Cardiac Arrest Team Training
Authors: Kim Ji-Hoon , Kim Young-Min , Park Seong Heui , Ju Eun A , Choi Se Min , Hong Tai Yong 
Published: March 2017

Objective
The aim of the study was to compare the educational impact of two postsimulation debriefing methods—focused and corrective feedback (FCF) versus Structured and Supported Debriefing (SSD)—on team dynamics in simulation-based cardiac arrest team training.

Methods
This was a pilot randomized controlled study conducted at a simulation center. Fourth-year medical students were randomly assigned to the FCF or SSD group, with each team composed of six students and a confederate. Each team participated in two simulations and the assigned debriefing (FCF or SSD) sessions and then underwent a test simulation. Two trained raters blindly assessed all of the recorded simulations using checklists. The primary outcome was the improvement in team dynamics scores between baseline and test simulation. The secondary outcomes were improvements before and after training in team clinical performance scores, self-assessed comprehension of and confidence in cardiac arrest management and team dynamics, as well as evaluations of the postsimulation debriefing intervention.

Results
In total, 95 students participated [FCF (8 teams, n = 47) and SSD (8 teams, n = 48)]. The SSD team dynamics score during the test simulation was higher than at baseline [baseline: 74.5 (65.9–80.9), test: 85.0 (71.9–87.6), P = 0.035]. However, there were no differences in the improvement in the team dynamics or team clinical performance scores between the two groups (P = 0.328, respectively).

Conclusions
There was no significant difference in improvement in team dynamics scores during the test simulation compared with baseline between the SSD and FCF groups in a simulation-based cardiac arrest team training in fourth-year Korean medical students.
Resveratrol induces mitochondrial dysfunction and decreases chronological life span ofSaccharomyces cerevisiaein a glucose-dependent manner
Authors: Ramos-Gomez Minerva , Olivares-Marin Ivanna Karina , Canizal-García Melina , González-Hernández Juan Carlos , Nava Gerardo M. , Madrigal-Perez Luis Alberto 
Published: March 2017

AbstractA broad range of health benefits have been attributed to resveratrol (RSV) supplementation in mammalian systems, including the increases in longevity. Nonetheless, despite the growing number of studies performed with RSV, the molecular mechanism by which it acts still remains unknown. Recently, it has been proposed that inhibition of the oxidative phosphorylation activity is the principal mechanism of RSV action. This mechanism suggests that RSV might induce mitochondrial dysfunction resulting in oxidative damage to cells with a concomitant decrease of cell viability and cellular life span. To prove this hypothesis, the chronological life span (CLS) ofSaccharomyces cerevisiaewas studied as it is accepted as an important model of oxidative damage and aging. In addition, oxygen consumption, mitochondrial membrane potential, and hydrogen peroxide (H2O2) release were measured in order to determine the extent of mitochondrial dysfunction. The results demonstrated that the supplementation ofS. cerevisiaecultures with 100 μM RSV decreased CLS in a glucose-dependent manner. At high-level glucose, RSV supplementation increased oxygen consumption during the exponential phase yeast cultures, but inhibited it in chronologically aged yeast cultures. However, at low-level glucose, oxygen consumption was inhibited in yeast cultures in the exponential phase as well as in chronologically aged cultures. Furthermore, RSV supplementation promoted the polarization of the mitochondrial membrane in both cultures. Finally, RSV decreased the release of H2O2with high-level glucose and increased it at low-level glucose. Altogether, this data supports the hypothesis that RSV supplementation decreases CLS as a result of mitochondrial dysfunction and this phenotype occurs in a glucose-dependent manner.
p53 is not necessary for DUX4 pathology
Authors: Bosnakovski Darko , Toso Erik A. , Recht Olivia O. , Cucak Anja , Jain Abhinav K , Barton Michelle C. , Kyba Michael 
Published: March 2017

AbstractsFSHD is a genetically dominant myopathy caused by mutations that cause expression of the normally silent DUX4 gene. This transcription factor has been shown to interfere with myogenesis when misexpressed at very low levels in myoblasts, and to cause cell death when overexpressed at high levels. A previous report using adeno-associated virus to deliver high levels of DUX4 to mouse skeletal muscle demonstrated severe pathology that was suppressed on a p53 knockout background, implying that DUX4 acted through the p53 pathway. Here, we investigate the p53-dependence of DUX4 using both in vitro cellular and the transgenic iDUX4[2.7] mouse models. We find that inhibiting p53 has no effect on the cytoxicity of DUX4 in vitro. When crossed onto the p53 null background, we find no suppression of the male-specific lethality or skin phenotypes of the DUX4 transgene, and find that primary myoblasts from this mouse are still killed by DUX4 expression. These data challenge the notion that the p53 pathway is central to the pathogenicity of DUX4.Summary StatementDUX4 is thought to mediate cytopathology through p53. Here, DUX4 is shown to kill primary myoblasts and promote pathological phenotypes in the iDUX4[2.7] mouse model on the p53-null background, calling into question this notion.
Is “transforming care” failing people with autism?
Authors: Marshall-Tate Karina , Chaplin Eddie , McCarthy Jane 
Published: March 2017

Purpose
The purpose of this paper is to comment on the development and implementation of transforming care (TC) and whether it has failed people with autism.

Design/methodology/approach
This paper is a commentary.

Findings
The number of people with autism being admitted to assessment and treatment units is increasing despite the aims of TC. The authors argue that TC, in serving such a diverse group of people, may have failed to identify the heterogeneity of such groups or recognise the different needs of people with mental illness and people with behaviours that challenge; and that TC could be regarded as a policy that only affects people with an intellectual disability.

Originality/value
Policymakers, policy implementers and health and social care staff may consider reviewing their practice to ensure that TC works for people with autism and their family and carers.
Maintainability analysis in shaving blades industry: a case study
Authors: Tsarouhas Panagiotis , Besseris George 
Published: March 2017

Purpose
The purpose of this paper is to provide results for a complete maintainability analysis utilizing data sets from a production system in a shaving blades division of a large high-tech razor manufacturer. Through the illustrated case study, the authors demonstrate how to spot improvement points for enhancing availability by carrying out an equipment effectiveness analysis.

Design/methodology/approach
Descriptive statistics of the repair data and the best fitness index parameters were computed. Repair data were collected from departmental logs, and a preliminary screening analysis was conducted to validate their usefulness for the indicated period of 11 months. Next, the maintainability and repair rate modes for all the machines of the production system were calculated. Maintainability and availability estimations for different time periods that took in account the overall system were obtained by trying out and selecting an optimum statistical model after considering of several popular distributions.

Findings
Out of the five considered machines in the system, two particular units received about half of the repairs (M2 and M3). The time to repair follows a loglogistic distribution and subsequently the mean time to repair is estimated at 25 minutes at the machine level. Repair time performance is approximated at 55 minutes if the availability of the system is to attain a 90 percent maintainability.

Originality/value
This study is anticipated to serve as an illuminating effort in conducting a complete maintainability analysis in the much advertised field of shavers, for which on the contrary so little has been published on operational availability and equipment effectiveness. The case study augments the available pool of sources where executing maintainability studies is highlighted usually under the direction of combined total quality management and total productive maintenance programs.
Optimum modified ramp-stress ALT plan with competing causes of failure
Authors: Srivastava Preeti Wanti , Gupta Tanu 
Published: March 2017

Purpose
Accelerated life test is undertaken to induce early failure in high-reliability products likely to last for several years. Most of these products are exposed to several fatal risk factors and fail due to one of them. Examples include solar lighting device with two failure modes: capacitor failure, and controller failure. It is necessary to assess each risk factor in the presence of other risk factors as each one cannot be studied in isolation. The purpose of this paper is to explore formulation of optimum time-censored accelerated life test model under modified ramp-stress loading when different failure causes have independent exponential life distributions.

Design/methodology/approach
The modified ramp-stress uses one test chamber in place of the various chambers used in the normal ramp-stress accelerate life test thus saving experimental cost. The stress-life relationship is modeled by inverse power law, and for each failure cause, a cumulative exposure model is assumed. The method of maximum likelihood is used for estimating design parameters. The optimal plan consists in finding out relevant experimental variables, namely, stress rate and stress rate change point(s).

Findings
The optimal plan is devised using D-optimality criterion which consists in finding out optimal stress rate and optimal stress rate change point by maximizing logarithm of determinant of Fisher information matrix to the base 10. This criterion is motivated by the fact that the volume of joint confidence region of model parameters is inversely proportional to square root of determinant of Fisher information matrix. The results of sensitivity analysis show that the plan is robust to small deviations from the true values of baseline parameters.

Originality/value
The model formulated can help reliability engineers obtain reliability estimates quickly of high-reliability products that are likely to last for several years.
Prioritising the enablers for the successful implementation of Kaizen in China
Authors: Ma Jie , Lin Zhibin , Lau Chi Keung 
Published: March 2017

Purpose
The purpose of this paper is to develop a better understanding of how Sino-Japanese joint ventures implemented the three Japanese improvement methods, i.e. Kaizen, Kaikaku and Kaizen Blitz. The specific objectives of this study are to identify the key enablers for the three improvement methods; and to identify the most selected improvement method.

Design/methodology/approach
This study employs a fuzzy analytic hierarchy process to pairwise-compare the three improvement methods. Data are collected from 28 industry experts from Sino-Japanese joint ventures. The study then adopts extent analysis approach for pairwise comparisons and extent analysis to obtain synthetic extent values for priority weights.

Findings
The results of the study indicate that personnel (humanware) factor enablers are the most important factor for Kaizen, whilst software factor enablers (essential rules, policies and institutional arrangements) weight second and hardware factor enablers (physical, measurable hard facts or resources) weight last. The study also reviews that Kaizen is the most selected improvement method among the three.

Research limitations/implications
The sample of this study is limited to Sino-Japanese ventures in Guangzhou, China. This study only identifies the key improvement enablers based on interviews with shop floor managers and improvement experts.

Practical implications
Practical implications are threefold: the improvement implementations should be based on factors such as regular training, incentives for motivations and shop floor management; improvement methods are transferable and standard operations may only have small effects on collecting improvement ideas; and Kaizen is the appropriate method to support long-term and process-oriented improvements.

Originality/value
This study is the first to specifically pairwise-compare the three Japanese improvement methods and to identify priorities of their key enablers in Sino-Japanese joint ventures.
Legitimization as a rhetorical process in a regulatory agency
Authors: Berry Alison 
Published: March 2017

PurposeThe purpose of this paper is to identify how the US Council for Higher Education Accreditation (CHEA) communicatively engaged in legitimization concerning accreditation.Design/methodology/approachThis study utilized the rhetorical analysis approach outlined by Hoffman and Ford (2010) to explore the accreditation-related texts from an online source created by CHEA, Information About Accreditation.FindingsThe analysis identified three overarching approaches to include: isomorphism to address regulatory legitimacy, organizational identity management to address pragmatic legitimacy, and a dialogic approach to address normative legitimacy. This analysis also developed a new theoretical model for the rhetorical construction of legitimacy, “A Model for the Rhetorical Construction of Legitimacy,” that can be summarized as: organizations foster a type of legitimacy through a legitimizing strategy by demonstrating how the purpose of the legitimizing strategy is achieved by the implementation of the legitimizing strategy.Research limitations/implicationsLimitations include that data were gathered only from online, web-based texts during a period in which the rhetorical situation was ongoing.Practical implicationsThis study expands research concerning the rhetorical approach to issues management in that it examines the way legitimacy is negotiated through the various rhetorical strategies of an organization. Additionally, information is offered about the rhetorical structure of texts when an organization seeks to legitimize certain ideas.Originality/valueThis analysis developed a theoretical model for the rhetorical construction of legitimacy, “A Model for the Rhetorical Construction of Legitimacy,” that demonstrates important relationships between legitimizing strategies and types of legitimacy. Understanding these relationships may allow for a better interpretation of how legitimacy theory is represented within a communicative venture.