bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model ensemble techniques of machine learning algorithms for soil moisture constants in the semi‐arid climate conditions
Authors: Alaboz Pelin 
Published: September 2024

AbstractIn recent years, the use of prediction models based on intelligent algorithms has become widespread in soil science. However, each algorithm has advantages and disadvantages, and variable results can occur on different datasets. The evaluation of ensemble techniques for solving these problems is the current approach. Water problems will arise due to global warming, and soil water will become more important. This study aims to evaluate the predictive accuracy of different machine learning algorithms (support vector machine regression (SVR), random forest (RF), artificial neural network (ANN), and multivariate linear regression (MLR)) and ensemble techniques (equal weight [EQ], Bates–Granger‐BG), Granger–Ramanathan (GR), Akaike information criterion (AIC), and Bayesian information criterion (BIC)) on the field capacity (FC), wilting point (WP) and available water content (AWC) of soils. As a result, higher prediction accuracy was obtained with the RF algorithm than with the value machine learning algorithm in the estimation of moisture constants. The coefficients of determination (R2) obtained for the prediction of FC, WP, and AWC via the RF algorithms were 0.624, 0.759 and 0.641, respectively. MLR had the highest error rate. Among the ensemble techniques, GR was the most successful. Lin's concordance correlation coefficient (LCCC) values obtained from the estimation of FC, WP, and AWC with the GR model were 0.801, 0.894, and 0.801, respectively. The root mean squared error (RMSE) and mean absolute error (MAE) values obtained in the estimation of the available water content with the MLR algorithm were 1.905 and 1.435, respectively, whereas these values were 1.173 and 0.767, respectively, when the GR model was used. As a result of the present study, better predictive results were obtained with ensemble techniques instead of evaluating the algorithms individually.
Longitudinal associations between parental psychological control and adolescents' intergroup attitudes to prosocial behaviors towards ethnic outgroups
Authors: Agalar Afra , Laible Deborah , Carlo Gustavo , Liew Jeffrey 
Published: September 2024

AbstractIntroductionWhile a substantial body of existing literature has examined the negative effects of parental psychological control on adolescents' prosocial behaviors, there is a noticeable gap in whether parental psychological control affects prosocial behaviors towards ethnic outgroup members. This three‐wave longitudinal study investigated whether similar relations can be observed between parental psychological control and prosocial behaviors targeted at ethnic outgroup persons, and whether these relations are mediated by adolescents' intergroup attitudes.MethodsParticipants were 412 European American adolescents (42% girls; Mage = 15.63 years at Time 1) and their primary caregivers (52% mothers) residing in the United States. They completed online questionnaires. Parents completed a measure of parental psychological control at Time 1. Adolescents completed measures of intergroup attitudes, public, and altruistic outgroup prosocial behavior at all three time points (T1, T2, T3), each approximately 8 months apart. The retention rate was 38.1% (N = 157; 44% girls) at Time 3.ResultsPath analyses revealed a direct negative link between parental psychological control and altruistic prosocial behavior towards ethnic outgroup persons but a direct positive association to public prosocial behavior towards outgroup persons. Importantly, parental psychological control was indirectly related to adolescents' prosocial behavior towards ethnic outgroup persons, via its effect on their intergroup attitudes.ConclusionsThe findings underscore how parental psychological control and adolescents' intergroup attitudes contribute to shaping prosocial behaviors towards ethnic outgroups.
Dentists’ knowledge, attitudes, and awareness regarding interprofessional collaboration with physical therapists
Authors: Fischer Kathleen M. , Harrison James L. , O'Malley DeGaris Megan A. , Granada Tara M. , Hartmann Julie , Knabel Courtney M. , Hill Margaret O. , Sekula Michael N. 
Published: September 2024

AbstractPurposeInterprofessional collaboration (IPC) between dentists and physical therapists (PT) could improve access to patient treatment and oral care outcomes. This study aimed to assess dentists' knowledge, attitudes, and awareness of IPC with PT.MethodsThe study design included a 16‐question online survey sent to dentists (n = 102) at a university in fall 2022 via SurveyMonkey. This survey evaluated dentists’ knowledge of PT services and IPC referrals, awareness of PT IPC improving oral health and continuing education (CE) opportunities, and attitudes toward team care. Statistical analysis was performed using Mann‐Whitney U, Kruskal‐Wallis, and Chi‐squared tests.ResultsParticipants included general dentists (71.2%) and dental specialists (28.8%), with experience ranging from 1‐5 years through 55+ years. Gender distribution included approximately 46.2% female and 53.8% male, with a survey response rate of 51.0% (n = 52). Females reported a significantly higher interest in PT IPC (p = 0.016) and referring (p = 0.022) than males. Dentists in practice for 21–40 years reported significantly higher participation in CE referral courses compared to other groups (p = 0.011). Compared to dental specialists, general dentists had a significantly more positive attitude when asked if dental collaboration with PT and physicians is equally important (p = 0.001). Additionally, 78.8% of respondents reported interest in attending a CE course on interprofessional education.ConclusionsThis study demonstrated dentists' limited awareness of the PT interprofessional collaborative approach. Females and general dentists reported higher positive attitudes toward PT IPC relationships. Most dentists were interested in attending additional IPC training.
Integrin α6‐containing extracellular vesicles promote lymphatic remodelling for pre‐metastatic niche formation in lymph nodes via interplay with CD151
Authors: Lin Yan , Zheng Hanhao , Jia Linpei , Luo Yuming , Zhang Dingwen , An Mingjie , Pang Mingrui , Diao Xiayao , Li Wenjie , Chen Jiancheng , Li Yuanlong , Liu Daiyin , Liu Zhicong , Huang Jian , Lin Tianxin , Chen Changhao 
Published: September 2024

AbstractHeterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation of pre‐metastatic “niches” in draining lymph nodes (LNs) to promote lymphatic metastasis. In order to identify the specific subpopulations of EVs involved, we performed high‐resolution proteomic analysis combined with nanoflow cytometry of bladder cancer (BCa) tissue‐derived EVs to identify a novel subset of tumour‐derived EVs that contain integrin α6 (ITGA6+EVs) and revealed the positive correlation of ITGA6+EVs with the formation of pre‐metastatic niche in draining LNs and lymphatic metastasis in multicentre clinical analysis of 820‐case BCa patients. BCa‐derived ITGA6+EVs induced E‐selectin (SELE)‐marked lymphatic remodelling pre‐metastatic niche and promoted metastasis in draining LNs through delivering cargo circRNA‐LIPAR to lymphatic endothelial cells in vivo and in vitro. Mechanistically, LIPAR linked ITGA6 to the switch II domain of RAB5A and sustained RAB5A GTP‐bound activated state, thus maintaining the production of ITGA6+EVs loaded with LIPAR through endosomal trafficking. ITGA6+EVs targeted lymphatic vessels through ITGA6‐CD151 interplay and released LIPAR to induce SELE overexpression‐marked lymphatic remodelling pre‐metastatic niche. Importantly, we constructed engineered‐ITGA6 EVs to inhibit lymphatic pre‐metastatic niche, which suppressed lymphatic metastasis and prolonged survival in preclinical models. Collectively, our study uncovers the mechanism of BCa‐derived ITGA6+EVs mediating pre‐metastatic niche and provides an engineered‐EV‐based strategy against BCa lymphatic metastasis.
Evaluation of bleeding risk in patients who received pirtobrutinib in the presence or absence of antithrombotic therapy
Authors: Lamanna Nicole , Tam Constantine S. , Woyach Jennifer A. , Alencar Alvaro J. , Palomba M. Lia , Zinzani Pier Luigi , Flinn Ian W. , Fakhri Bita , Cohen Jonathon B. , Kontos Arrin , Konig Heiko , Ruppert Amy S. , Chatterjee Anindya , Sizelove Richard , Compte Livia , Tsai Donald E. , Jurczak Wojciech 
Published: September 2024

AbstractClinical bleeding events are reported here from 773 patients with B‐cell malignancies receiving pirtobrutinib monotherapy from the phase 1/2 BRUIN study (ClinicalTrials.gov identifier: NCT03740529), either in the presence or absence of antithrombotic therapy (antithrombotic exposed [AT‐E], n = 216; antithrombotic nonexposed [AT‐NE], n = 557). Among the AT‐E cohort, 51.9% received platelet aggregation inhibitors, 36.6% received direct factor Xa inhibitors, 18.5% received heparins, 5.6% received salicylic acid for indications other than platelet aggregation inhibition, and 2.3% received thrombolytics. Warfarin was not permitted. Any‐grade bleeding/bruising events occurred in 97 patients (44.9%; 95% confidence interval [CI], 38.3–51.5) in the AT‐E cohort and 181 patients (32.5%; 95% CI, 28.6–36.4) in the AT‐NE cohort. Most bleeding/bruising events in both cohorts began within the first 6 months of treatment (AT‐E: 65.4%; AT‐NE: 72.5%). Contusion was the most common bleeding/bruising event in both cohorts (AT‐E: 22.7%; AT‐NE: 18.1%). Grade ≥3 bleeding/bruising events were reported in six patients (2.8%) in the AT‐E cohort and 11 patients (2.0%) in the AT‐NE cohort. Bleeding/bruising events requiring or prolonging hospitalization were reported in 2.3% and 1.6% of patients in the AT‐E and AT‐NE cohorts, respectively. No bleeding/bruising events led to pirtobrutinib dose reduction or permanent discontinuation in the AT‐E cohort, and one patient (0.2%) in the AT‐NE cohort experienced an event requiring dose reduction. These data support the safety of pirtobrutinib in patients requiring antithrombotic therapies.
Pleomorphic Liposarcoma of the Extremity and Trunk: Multimodality Therapy for Some but Not All?
Authors: Tseng William W. , Barretta Francesco , Tucci Francesco , Barisella Marta , Radaelli Stefano , Colombo Chiara , Callegaro Dario , Morosi Carlo , Sanfilippo Roberta , Fabbroni Chiara , Stacchiotti Silvia , Sun Steven H. , Collini Paola , Fiore Marco , Gronchi Alessandro 
Published: September 2024

ABSTRACTBackgroundPleomorphic liposarcoma (PLPS) is an ultra‐rare malignancy distinct from well‐differentiated/dedifferentiated and myxoid liposarcoma. In this study, we sought to (1) assess outcomes after surgery for primary, non‐metastatic PLPS and (2) explore potential indications for multimodality therapy.MethodsClinicopathologic data were retrospectively collected for patients treated from 2002 to 2019 at our sarcoma referral center. Descriptive data were summarized and Kaplan–Meier plots were constructed for overall survival (OS) and crude cumulative incidences (CCI) of disease‐specific death (DSD), local recurrence (LR), and distant metastasis (DM). Univariable models were performed to assess the association of specific variables of interest on outcome.ResultsForty‐four pathology‐verified PLPS cases were included in this study. Median tumor size was 8.5 cm; 75% were FNCLCC Grade 3. All patients underwent complete resection, including 15 patients (34%) who required re‐excision to secure microscopic negative margins. Radiation therapy was given to 75% of patients, chemotherapy in 36%. At 5 years, OS was 75.3%; CCI of DSD, LR, and DM were 17.5%, 2.3%, and 32.5%. Larger tumor size was strongly associated with worse OS (p = 0.028) and DSD (p ≤ 0.001). A subgroup of patients (n = 10, 23%) with smaller, predominantly Grade 2 tumors underwent surgery alone without any LR or DM event at a median follow‐up of 7.9 years.ConclusionsIn PLPS, aggressive surgery and when appropriate, radiation therapy, results in excellent local control. Chemotherapy can be considered for larger tumors. Patients with smaller, Grade 2 tumors may be potentially cured with surgery alone.
A Review of Functional Properties and Applications of Legume‐Based Edible Coatings
Authors: Thamarsha A. K. A. N. W. M. R. K. , Kumar Nishant , Pratibha  , Mor Kiran , Upadhyay Ashutosh , Sudhani Hemanth P. K. , Pamu Venkata Sarath 
Published: September 2024

ABSTRACTLegumes are rich in starch, proteins, lipids, vitamins, and minerals, making them a better source for developing films with high nutritional value. They have become a sustainable and eco‐friendly coating to prolong the shelf life of perishable products while preserving both quality and safety. Legume‐based polysaccharides and proteins are cost‐effective materials to use as an alternative to synthetic materials. Additionally, legume‐based edible coatings are gluten free and acceptable to consumers with dietary restrictions for coatings derived from nonplant sources. Their use in edible coating further extends the economic significance of legumes. The physicochemical properties of these coatings may vary based on several factors including composition of the film, conditions of processing, and additives used. Legume‐based edible coatings and films hold the ability to enhance the shelf life and quality of food items by acting as barriers against oxygen, moisture, and solute transfer. Also, they can aid in maintaining the nutritional value, flavor, and sensory qualities of food products. Incorporation of bioactive compounds, such as antioxidants and antimicrobials, into legume‐based coatings further enhances their functionality in food preservation. This article provides an in‐depth review of the current state of research on legume‐based edible coatings, focusing on their development, physical and mechanical properties, applications in food preservation, and future scope.
The History and Pedigree of Australian Lentil Cultivars
Authors: Thackwray Em L. , Materne Michael A. , Shunmugam Arun S. K. , Henares Bernadette M. , Lee Robert C. , Kamphuis Lars G. 
Published: September 2024

ABSTRACTLentils are an ancient, edible grain legume, consumed worldwide in an array of dishes as either whole or split seed. While India and Canada are the largest modern‐day producers, Australia is a close third and the second largest exporter of lentil globally. An overview of lentil introduction cultivar development and production in Australia since the 1960s is presented. This commenced with obtaining international germplasm, and in the 1970s, Australia participated in the ICARDA‐led Food Legume Improvement Program (FLIP), which saw the release of nine varieties in the span of a decade. The first local breeding efforts in Australia commenced in the 1990s through the Coordinated Improvement Program for Australian Lentils (CIPAL), which transitioned into Pulse Breeding Australia (PBA) in the 2000s, and saw the first Australian‐bred varieties released in 2008. Currently, Agriculture Victoria's National Lentil Breeding Program and Grains Innovation Australia (GIA) breed and release varieties for Australian lentil growers, and future perspectives for their programmes are presented. One of the main diseases of lentil is Ascochyta blight, which is caused by the fungus Ascochyta lentis. The discovery of a major avirulence gene within Australian A. lentis populations which determines pathotype has allowed recent categorisation of a collection of isolates, and their response to Australian varieties is discussed. The narrowing gene pool and viability of interspecific hybridisation of Australian lentil is additionally explained. Taken together, this review summarises the history and pedigree of Australian varieties and lentil breeding, the impact of major disease pathotypes on cultivar utility and the pursuits of public and private lentil breeding initiatives.
Laser‐Driven (Ga/Sc)2O3:Cr3+ Luminescent Ceramics Enabling Near‐Infrared Light Source for Noninvasive Imaging and Detection
Authors: Xiong Zhan , Liu Gaochao , Chen Weibin , Xia Zhiguo 
Published: September 2024

AbstractHigh‐power broadband near‐infrared (NIR) light sources have received extensive attention in long‐distance night vision lighting, non‐invasive detection and imaging, and quantitative analysis of organic components. However, developing targeted NIR‐emitting phosphors with high external quantum efficiency (EQE) and thermal stability remains a challenge to raise the NIR output power and expand the applications. Herein, Ga1.98−xScxO3:0.02Cr3+ luminescent ceramics are prepared with redshifted emission peaks from 710 to 820 nm depending on the weakened crystal field. The optimized Ga1.18Sc0.8O3:0.02Cr3+ ceramic exhibits a high EQE of 79.6% and excellent thermal stability (I423 K/I298 K = 72%) under 468 nm excitation, which brings a saturation threshold up to 893 mW@3 W mm−2 under 450 nm laser pumping. The high‐power laser‐driven broadband NIR light source demonstrates potential in non‐invasive detection and quantitative analysis of alcohol concentration. This study opens up new avenues for the exploration of high‐power broadband NIR light sources.
The Protective Potential of Butyrate against Colon Cancer Cell Migration and Invasion Is Critically Dependent on Cell Type
Authors: Oncel Sema , Safratowich Bryan D. , Zeng Huawei 
Published: September 2024

ScopeShort‐chain fatty acids such as butyrate are produced through the fermentation of dietary fiber by colonic bacteria. Preclinical studies indicate an anticancer potential of butyrate, but clinical evidence shows greater variability. The study hypothesizes the effectiveness of butyrate on reducing colon cancer cell migration and invasion may vary due to the cell‐type.Methods and resultsThe study determines the efficacy of butyrate (0–4 mM) to inhibit cancer cell migration, invasion, and related signaling proteins in three distinct human colorectal cancer (CRC) cell lines: HCT116, HT‐29, and Caco‐2. Butyrate exhibits a dose‐dependent inhibitory effect on cancer cell migration and invasion. This inhibitory potential on oncogenic focal adhesion kinase (FAK) and sarcoma (Src) proteins is greater in HCT116 cells (1.1 and 0.8‐fold) and HT‐29 cells (0.9 and 0.4‐fold) compared to Caco‐2 cells, respectively. Conversely, E‐cadherin protein, a classical epithelial cell marker and potential tumor suppressor, is 2.3‐fold greater in HCT116 cells than in HT‐29 cells and Caco‐2 cells. Moreover, survival analysis from a public cancer database demonstrates that CRC patients with high E‐cadherin expression have a 13% greater 5‐year survival rate than those with low expression.ConclusionCollectively, butyrate's anti‐cancer efficacy on CRC cells varies depending on cell‐type and is linked to the FAK/Src/E‐cadherin pathway.
The Effect of Telerehabilitation‐Based Self‐Management Programme on Individuals With Scleroderma
Authors: Karakuş Emirhan , Sari Fulden , Avanoğlu Güler Aslıhan , Oskay Deran , Öksüz Çiğdem 
Published: September 2024

ABSTRACTObjectivesOur study endeavoured to develop an online self‐management programme facilitated by an interdisciplinary team and to assess its impact on the quality of life, sleep patterns, pain perception, and fatigue levels among individuals diagnosed with scleroderma.MethodsTwenty‐nine individuals with scleroderma completed the programme. The study spanned 8 weeks during which participants received weekly 45‐min video sessions. Assessment tools included the Scleroderma Health Assessment Questionnaire (SHAQ) for disease severity and pain intensity, the Self‐Efficacy Scale for Chronic Disease Patients for self‐management evaluation, the Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality, the Fatigue Severity Scale for measuring fatigue severity, and the Short Form‐12 Quality of Life Scale (SF‐12) for evaluating quality of life.ResultsSelf‐management score increased significantly, while fatigue score decreased significantly. Feedback from participants indicated a positive perception of the programme and its content, suggesting its usefulness in managing their condition. Feedback from participants indicated a positive perception of the programme and its content, suggesting its usefulness in managing their condition.ConclusionsThe self‐management programme, developed collaboratively by an interdisciplinary team and implemented via telerehabilitation, yielded beneficial outcomes concerning self‐management skills and fatigue severity among individuals with scleroderma. Strengthening the interdisciplinary composition of the study team by incorporating diverse healthcare professionals may enhance future investigations. Additionally, we advocate for the repetition of the study employing randomised methodologies and implementing long‐term follow‐up assessments to further elucidate the programme's efficacy and sustainability over time.
Intelligent Parameter Identification for a High‐Cycle Accumulation Model of Sand With Enhancement of Cuckoo Search Algorithm
Authors: He Shao‐Heng , Yin Zhen‐Yu , Sun Yifei , Ding Zhi 
Published: September 2024

ABSTRACTThis study presents a novel approach of intelligent parameter identification (IPI) for a high‐cycle accumulation (HCA) model of sand, which reduces the subjective errors on manual parameter calibration and makes the use of the HCA model more accessible. The technique is based on optimization theory and adopts the cuckoo search algorithm (CSA). To improve search ability and convergence speed of CSA, several enhancements are implemented. First, the improved CSA (ICSA) incorporates quasi‐opposition learning to expand the search space and replaces the original search strategy with a Cauchy random walk to enhance global search ability. Second, an adaptive scaling factor is introduced in the algorithm's control parameters to achieve a better balance between exploration speed and accuracy. Third, a dynamic inertia weight is used to balance the search between global and local spaces when generating new nest positions after abandoning old ones. The performance of the ICSA‐based IPI approach is evaluated by comparing it with the original CSA‐based IPI and manual calibration in determining the HCA model parameters. A comprehensive analysis is also conducted to assess the effectiveness and superiority of each improvement strategy introduced in the ICSA over the original CSA. All comparisons demonstrate that the proposed ICSA‐based IPI method is more powerful and efficient in finding optimal parameters.