bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language and Visuality of the Mentally Ill
Authors: Charvát Martin , Pudlák Štěpán 
Published: January 2016

AbstractIn the present paper we argue that Sigmund Freud's analysis of mental disorders is based almost exclusively on language and thus it omits other semiotic modalities, prominently visuality. Freud's psychoanalytical theory originates in the discovery that the speech of mentally ill patients is a basis for their treatment. A psychoanalyst is an interpreter who “translates” patient's speech into expression of original, suppressed thoughts. However, this analytical process was never applicable on psychotic patients, since their speech and thought processes are often distorted. This insistence on language can be limiting. Patients can produce “material” for interpretation not only in a form of language, but for instance in a form of visuality. In this respect, art brut, the visual art of the mentally ill, can be analyzed. But in order to do so, we have to reconsider Freud's original concept of translation of one level of signs (neurotic symptoms) into another (basis of the neurosis). An analysis of visual art of the mentally ill can rather focus on the relations between specific signs of the painting in order to understand how psychosis works. The paper provides general remarks and examples of such an analysis. Copyright © 2016 John Wiley & Sons, Ltd.
The interval between carotid artery stenting and open heart surgery is related to perioperative complications
Authors: Dong Hui , Jiang Xiongjing , Peng Meng , Zou Yubao , Che Wuqiang , Qian Haiyan , Xu Bo , Song Lei , Yang Yuejin , Gao Runlin 
Published: January 2016

ObjectivesTo assess 30‐day outcomes and the optimal interval between carotid artery stenting (CAS) and open heart surgery (OHS).BackgroundWhether or not they show symptoms of carotid atherosclerosis, patients with significant carotid stenosis who underwent OHS face a high risk of perioperative stroke. Planning appropriate treatment for carotid stenosis before OHS has become an important clinical issue.MethodsFrom January 2005 to June 2010, 154 inpatients scheduled for CAS and OHS were recruited and followed up for 30 days after OHS. The primary end point was a composite of major stroke or neurological death. The secondary end points included a composite of major stroke, myocardial infarction (MI) or any death, minor stroke, and acute kidney injury (AKI).ResultsThe incidence of the primary end point, the composite of major stroke, MI or any death, minor stroke and AKI was 3.2%, 5.8%, 2.6%, and 4.5%, respectively. Only an interval between CAS and OHS of ≤5 days could independently predict the incidence of the primary end point (OR, 14.06, 95% CI, 1.52‐130.13; P=0.020). Moreover, congestive heart failure (OR, 7.07, 95% CI, 1.55‐21.27; P=0.012) and an interval between CAS and OHS of ≤5 days (OR, 7.05, 95% CI, 1.58‐31.40; P=0.010) were identified as independent risk factors for the composite of major stroke, MI, or any death.ConclusionsOur findings indicate that CAS followed by OHS is safe and feasible. More importantly, an interval between CAS and OHS of >5 days may decrease periprocedural complications, especially major stroke and neurological death. © 2016 Wiley Periodicals, Inc.
Synthesis, Voltammetric and Analytical Applications of Some Fluorine Substituted Spirosteroidalthiazolidin‐4‐one Derivatives of Sulfa Drugs
Authors: Makki M. S. T. , Alfooty K. O. , Abdel‐Rahman R. M. , El‐Shahawi M. S. 
Published: January 2016

AbstractA new 5‐arylidene‐4‐oxo‐(sulfonamoyl phenyl)‐spiro[thiazolidinone‐2,2′‐steroids] series (7–10) was prepared by condensation of sulfanilamide, sulfapyridine and sulfadiazine sulfa drugs with testosterone, epiandrosterone and progesterone steroids, respectively. The resultant imino derivatives 1–3 upon cycloaddition with thioacetic acid in dry 1,4‐dioxane afforded 3‐sulfo‐namoylphenylspiro[4‐oxo‐thiazolidin‐2,2′steroids] (4–6). The latter compounds (4–6) upon condensation with p‐fluorobenzaldehyde in ethanol‐piperidine yielded the corresponding 4‐fluoroarylidene derivatives 7, 8 & 9, respectively. All the newly synthesized compounds were confirmed by UV, IR, 1H NMR, 13C NMR, mass spectral data, elemental analysis and molecular weight determination. In vitro antimicrobial screening of some of the synthesized compounds showed good antimicrobial activities towards some pathogenic Gram‐positive, Gram‐negative bacteria and fungi vs. piperacillin and mycostatine antibiotics as standard antibacterial and antifungal agents, respectively. The voltammetric behavior of two newly spirothiazolidinone steroids (2a & 5a) was critically studied. Compound 5a physically immobilized polyurethane foam solid sorbent was successfully used for removal and/or separation of bismuth(III) from water.
L'expressionentre guillemets. Un marqueur de modalisation à la mode
Authors: BRANCA-ROSOFF SONIA 
Published: January 2016

RÉSUMÉCet article aborde la question de la formation et de la diffusion du modalisateur entre guillemets en exploitant trois sortes de données. Frantext permet d'examiner ses commencements vers 1913; le web, le moment où son usage est ressenti comme proliférant entre 2000 et 2010; le corpus CFPP2000, sa diffusion – peut-être provisoire – à l'oral.Les résultats montrent qu'il est suremployé par des locuteurs des couches moyennes d'origine populaire. Cependant, l'expression ne connaît pas la perte de contenu sémantique caractéristique de la pragmaticalisation. Ses emplois restent ceux d'un modalisateur signalant une défaillance dans la nomination du réel.
Rehabilitation of Executive Functions in Patients with Chronic Acquired Brain Injury with Goal Management Training, External Cuing, and Emotional Regulation: A Randomized Controlled Trial
Authors: Tornås Sveinung , Løvstad Marianne , Solbakk Anne-Kristin , Evans Jonathan , Endestad Tor , Hol Per Kristian , Schanke Anne-Kristine , Stubberud Jan 
Published: January 2016

AbstractExecutive dysfunction is a common consequence of acquired brain injury (ABI), causing significant disability in daily life. This randomized controlled trial investigated the efficacy of Goal Management TrainingTM(GMT) in improving executive functioning in patients with chronic ABI. Seventy patients with a verified ABI and executive dysfunction were randomly allocated to GMT (n=33) or a psycho-educative active control condition, Brain Health Workshop (BHW) (n=37). In addition, all participants received external cueing by text messages. Neuropsychological tests and self-reported questionnaires of executive functioning were administered pre-intervention, immediately after intervention, and at 6 months follow-up. Assessors were blinded to group allocation. Questionnaire measures indicated significant improvement of everyday executive functioning in the GMT group, with effects lasting at least 6 months post-treatment. Both groups improved on the majority of the applied neuropsychological tests. However, improved performance on tests demanding executive attention was most prominent in the GMT group. The results indicate that GMT combined with external cueing is an effective metacognitive strategy training method, ameliorating executive dysfunction in daily life for patients with chronic ABI. The strongest effects were seen on self-report measures of executive functions 6 months post-treatment, suggesting that strategies learned in GMT were applied and consolidated in everyday life after the end of training. Furthermore, these findings show that executive dysfunction can be improved years after the ABI. (JINS, 2016,22, 436–452)
Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model
Authors: Subburaju S , Coleman A J , Ruzicka W B , Benes F M 
Published: January 2016

AbstractSchizophrenia (SZ) is associated with GABA neuron dysfunction in the hippocampus, particularly the stratum oriens of sector CA3/2. A gene expression profile analysis of human postmortem hippocampal tissue followed by a network association analysis had shown a number of genes differentially regulated in SZ, including the epigenetic factors HDAC1 and DAXX. To characterize the contribution of these factors to the developmental perturbation hypothesized to underlie SZ, lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX were used. In the hippocampal GABA neuron culture model, HiB5, transduction with HDAC1 shRNAi showed a 40% inhibition of HDAC1 mRNA and a 60% inhibition of HDAC1 protein. GAD67, a enzyme associated with GABA synthesis, was increased twofold (mRNA); the protein showed a 35% increase. The expression of DAXX, a co-repressor of HDAC1, was not influenced by HDAC1 inhibition. Transduction of HiB5 cells with DAXX shRNAi resulted in a 30% inhibition of DAXX mRNA that translated into a 90% inhibition of DAXX protein. GAD1 mRNA was upregulated fourfold, while its protein increased by ~30%. HDAC1 expression was not altered by inhibition of DAXX. However, a physical interaction between HDAC1 and DAXX was demonstrated by co-immunoprecipitation. Inhibition of HDAC1 or DAXX increased expression of egr-1, transcription factor that had previously been shown to regulate the GAD67 promoter. Our in vitro results point to a key role of both HDAC1 and DAXX in the regulation of GAD67 in GABAergic HiB5 cells, strongly suggesting that these epigenetic/transcription factors contribute to mechanisms underlying GABA cell dysfunction in SZ.
Leader-member exchange and job performance
Authors: Choy Jerome , McCormack Darcy , Djurkovic Nikola 
Published: January 2016

Purpose– The purpose of this paper is to examine the relationship between leader-member exchange (LMX) and job performance and the utility of delegation and participation as mediators of the aforementioned relationship.Methodology– A survey approach was used in this research. Regression analyses, including mediation analyses, on data from 268 employees in a large public sector organisation were conducted.Findings– The findings revealed that both delegation and participation were significant mediating variables of the relationship between LMX and job performance.Research limitation– The limitations of the study include the use of self-report and cross-sectional data. Future research could include multi-source data, and a longitudinal research design.Practical implication– The implications of the findings for theory and management are discussed, including the use of delegation and participation as effective instruments for developing and maintaining strong manager-employee relationships to improve social capital and enhance job performance.Originality value– This paper enhances understanding of LMX, and sheds some light on how LMX and participative decision making can influence employee job performance.
Enhancing knowledge adoption with recipients’ characteristics
Authors: Chirawattanakij Suphong , Vathanophas Ractham Vichita 
Published: January 2016

Purpose– The purpose of this paper is to envisage human characteristics and resources as critical factors in the adoption process. While an individual’s intention to adopt knowledge is considered as the primary motivator in the adoption process, these characteristics, in the appropriate amount, can accelerate the recipients’ knowledge adoption behavior. In this study four personal characteristics, comprising shared language between a knowledge sender and a recipient, the recipient’s prior knowledge, the recipient’s enjoyment in adopting knowledge, and the recipient’s self-confidence have been chosen.Methodology– This research uses four human characteristics, consisting of shared language between knowledge senders and recipients, recipients’ prior knowledge, recipients’ enjoyment in knowledge adoption, and recipients’ self-confidence, to identify their optimal roles in the adoption process. Along with the intention to adopt new knowledge, each of these characteristics was tested in both forms. A survey was conducted with white collar workers. Nine models were designed and regression technique was used for analyzing data and interpreting outcomes of these models.Findings– This study reveals that shared language between a knowledge sender and a recipient as well as a recipient’s self-confidence to adopt new knowledge directly enhances the individual’s likelihood to start learning. Shared language and self-confidence perform better as mutual predictors, while prior knowledge and enjoyment are the moderators.Originality value– The research outcome is beneficial in the designing of organizational business strategies. Shared language between an instructor and a learner increases likelihood to adopt knowledge, thus it is advantageous to arrange prerequisite mandatory courses in order to enhance a learner’s language proficiencies. Organizations can leverage their employees’ prior knowledge if it is perceived to be low. To do so, supervisors should link eagerness in learning and augmenting competencies to career advancement. Advice from, and rapport with a supervisor is essential. Effective strategies can improve the knowledge sharing goals, and in turn achieve business objectives as a whole.
The Interval Testing Procedure: A General Framework for Inference in Functional Data Analysis
Authors: Pini Alessia , Vantini Simone 
Published: January 2016

SummaryWe introduce in this work the Interval Testing Procedure (ITP), a novel inferential technique for functional data. The procedure can be used to test different functional hypotheses, e.g., distributional equality between two or more functional populations, equality of mean function of a functional population to a reference. ITP involves three steps: (i) the representation of data on a (possibly high-dimensional) functional basis; (ii) the test of each possible set of consecutive basis coefficients; (iii) the computation of the adjusted p-values associated to each basis component, by means of a new strategy here proposed. We define a new type of error control, the interval-wise control of the family wise error rate, particularly suited for functional data. We show that ITP is provided with such a control. A simulation study comparing ITP with other testing procedures is reported. ITP is then applied to the analysis of hemodynamical features involved with cerebral aneurysm pathology. ITP is implemented in the fdatest R package.
Nocardiosis following hematopoietic stem cell transplantation
Authors: Shannon K. , Pasikhova Y. , Ibekweh Q. , Ludlow S. , Baluch A. 
Published: January 2016

AbstractBackgroundNocardia species are ubiquitous environmental organisms that can cause a diverse spectrum of disease. Clinical manifestations range from localized skin and soft tissue infections to life‐threatening pulmonary, central nervous system, and/or disseminated infections. Patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) are at risk for nocardiosis, and further data in regard to characteristics of disease in this population are warranted.MethodsWe performed retrospective chart review of patients post allogeneic HSCT at Moffitt Cancer Center in Florida diagnosed with nocardiosis from 2003 to 2013.ResultsIn a decade, 15 cases of nocardiosis were identified. The majority of patients were men (11/15). The median age was 55 years (range 25–65). The most common type of transplant was matched‐related donor (n = 8), followed by matched‐unrelated donor (n = 3), mismatched‐unrelated donor (n = 3), and double umbilical cord (n = 1). Ten received myeloablative conditioning (MAC) regimens. Twelve of 15 patients were on prednisone, 10 of which were on a total daily dose ≥20 mg. The median time from transplant to first positive culture was 10 months (range 1.5–93). Pulmonary nocardiosis was the most prevalent manifestation at 87%. Disseminated disease (2 or more sites of infection) was seen in 47%, whereas blood cultures were positive in 27% of the total cohort. The most common species was Nocardia nova (n = 4). At the time of diagnosis, 20% of the patients were receiving prophylaxis for Pneumocystis jirovecii pneumonia (PJP) with trimethoprim–sulfamethoxazole (TMP‐SMX). Susceptibility data were available for 8 patients: all 8 samples were susceptible to TMP‐SMX. Nocardiosis was treated with 2 or more active drugs in 93% of the patients. Overall mortality was 53%, with nocardiosis attributed as the cause in 62.5% (5/8). The absolute lymphocyte count at time of diagnoses was significantly lower in patients who ultimately experienced treatment failure.ConclusionInfection with Nocardia species in allogeneic HSCT recipients appears to be a late complication of transplantation and most commonly involves the lung. Two‐thirds of the cohort received a MAC regimen and the majority of the patients were receiving steroids at the time of diagnosis. Most patients were not receiving TMP‐SMX for PJP prophylaxis at the time of nocardiosis diagnosis, and TMP‐SMX may therefore have a protective effect.
Design of and rationale for the Japan Diabetes Optimal Integrated Treatment study for 3 major risk factors of cardiovascular diseases (J-DOIT3): a multicenter, open-label, randomized, parallel-group trial
Authors: Ueki Kohjiro , Sasako Takayoshi , Kato Masayuki , Okazaki Yukiko , Okahata Sumie , Katsuyama Hisayuki , Haraguchi Mikiko , Morita Ai , Ohashi Ken , Hara Kazuo , Morise Atsushi , Izumi Kazuo , Ohashi Yasuo , Noda Mitsuhiko , Kadowaki Takashi ,   the J-DOIT3 Study Group
Published: January 2016

ObjectiveMultifactorial intervention including the management of levels of blood glucose (BG), blood pressure (BP), and lipids has been suggested to decrease cardiovascular disease (CVD) risk. However, the target ideal and feasible levels for these individual parameters have not been fully evaluated. In this study, we examine the hypothesis that stricter control compared with the current targets in the Japanese guideline for BG, BP, and lipids could efficiently and safely reduce CVD risk.Research Design and MethodsWe screened patients with type 2 diabetes and hypertension and/or dyslipidemia among 81 hospitals in Japan and allocated them into 2 groups: the intensive therapy group (ITG) and the conventional therapy group (CTG). For the 2 respective groups, the target for glycated hemoglobin (HbA1c) is <6.2% (44 mmol/mol) and <6.9% (52 mmol/mol), for BP it is <120/75 mm Hg and <130/80 mm Hg, and for low-density lipoprotein cholesterol it is <80 mg/dL (<70 mg/dL in the presence of CVD history) and <120 mg/dL (<100 mg/dL in the presence of CVD history). The primary end point is the occurrence of CVD events or death by any cause. These patients are scheduled for stepwise intensifications of medication for BG, BP, and lipid control in the ITG, until the number of primary end point events reaches 250.ResultsWe recruited 2542 patients and randomly allocated 1271 into the ITG and 1271 into the CTG between June 2006 and March 2009. The mean HbA1c was 8.0% (64 mmol/mol) and the mean duration of diabetes was 8.3 years.ConclusionsThis randomized controlled study will test the hypothesis that strict multifactorial intervention therapy is effective for the prevention of CVDs in patients with type 2 diabetes who are at high CVD risk.Trial registration numberNCT00300976.
Structure of the ocean–continent transition, location of the continent–ocean boundary and magmatic type of the northern Angolan margin from integrated quantitative analysis of deep seismic reflection and gravity anomaly data
Authors: Cowie L. , Angelo R. M. , Kusznir N. , Manatschal G. , Horn B. 
Published: January 2016

Abstract

The crustal structure and distribution of crustal types on the northern Angolan rifted continental margin have been the subject of much debate. Hyper-extended continental crust, oceanic crust and exhumed serpentinized mantle have all been proposed to underlie the Aptian salt and the underlying sag sequence. Quantitative analysis of deep seismic reflection and gravity anomaly data, together with reverse post-break-up subsidence modelling, have been used to investigate the ocean–continent transition structure, the location of the continent–ocean boundary, the crustal type and the palaeobathymetry of Aptian salt deposition. Gravity inversion methods (used to give the depth to the Moho and the crustal thickness), residual depth anomaly analysis (used to identify departures from oceanic bathymetry) and subsidence analysis have all shown that the distal Aptian salt is underlain by hyper-extended continental crust rather than exhumed mantle or oceanic crust. We propose that the Aptian salt was deposited
c.
0.2 and 0.6 km below global sea-level and that the inner proximal salt subsided by post-rift (post-tectonic) thermal subsidence alone, whereas outer distal salt formation was synrift, prior to break-up, resulting in additional tectonic subsidence. Our analysis argues against Aptian salt deposition on the Angolan margin in a 2–3 km deep isolated ocean basin and supports salt deposition on hyper-extended continental crust formed by diachronous rifting migrating from east to west and culminating in the late Aptian.
Making Lock-free Data Structures Verifiable with Artificial Transactions
Authors: Yuan Xinhao , Williams-King David , Yang Junfeng , Sethumadhavan Simha 
Published: January 2016

Among all classes of parallel programming abstractions, lock-free data structures are considered one of the most scalable and efficient thanks to their fine-grained style of synchronization. However, they are also challenging for developers and tools to verify because of the huge number of possible interleavings that result from finegrained synchronizations.
This paper addresses this fundamental problem between performance and verifiability of lock-free data structure implementations. We present TXIT, a system that greatly reduces the set of possible interleavings by inserting transactions into the implementation of a lock-free data structure. We leverage hardware transactional memory support from Intel Haswell processors to enforce these artificial transactions. Evaluation on six popular lock-free data structure libraries shows that TXIT makes it easy to verify lock-free data structures while incurring acceptable runtime overhead. Further analysis shows that two inefficiencies in Haswell are the largest contributors to this overhead.