bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is intra‐procedure three‐dimensional transesophageal echocardiogram an alternative to preprocedure multidetector computed tomography for the measurement of the aortic annulus in patients undergoing transcatheter aortic valve replacement?
Authors: Hafiz Abdul Moiz , Medranda Giorgio A. , Kakouros Nikolaos , Patel Jay , Kahan Jonathan , Gubernikoff George , Ray Beevash , Paruchuri Vijayapraveena , DeLeon Joshua , Marzo Kevin , Calixte Rose , Gaztanaga Juan 
Published: July 2017

BackgroundThe role of three‐dimensional transesophageal echocardiography (3DTEE) vs multidetector computed tomography (MDCT) in aortic annular sizing has been poorly defined in patients undergoing transcatheter aortic valve replacements (TAVR). We set to determine the correlation between 3DTEE and MDCT in measuring the aortic annulus prior to TAVR.MethodsIn an observational, retrospective study, we compared aortic annular areas measured by MDCT and 3DTEE in TAVR patients. The aortic annular area was measured by planimetry of images obtained by MDCT pre‐TAVR and by intra‐TAVR TEE using 3D rendering of the aortic annulus followed by planimetry. Our primary outcome was degree of correlation between mean aortic annulus area by 3DTEE and MDCT.ResultsOf the 111 consecutive patients undergoing TAVR who had measurements from both modalities available for comparison between February 2012 and April 2015, 87 met inclusion criteria. The mean aortic annular area by MDCT was 4.44±0.88 cm2 and by 3DTEE was 4.33±0.78 cm2. There was a strong positive linear correlation between aortic annular area measurements obtained from these two modalities with mild relative underestimation by 3DTEE (ρ=.833). This relationship can be estimated using the predictive formula: urn:x-wiley:07422822:media:echo13613:echo13613-math-0001ConclusionsThree‐dimensional transesophageal echocardiography measurements have a high degree of correlation with MDCT measurements and thus can assist in proper valve prosthesis selection for TAVR. Our study thus supports use of 3DTEE as a reasonable alternative imaging modality in patients undergoing TAVR.
Pathology Imagebase—a reference image database for standardization of pathology
Authors: Egevad Lars , Cheville John , Evans Andrew J , Hörnblad Jonas , Kench James G , Kristiansen Glen , Leite Katia R M , Magi‐Galluzzi Cristina , Pan Chin‐Chen , Samaratunga Hemamali , Srigley John R , True Lawrence , Zhou Ming , Clements Mark , Delahunt Brett ,   The ISUP Pathology Imagebase Expert Panel
Published: July 2017

AimsDespite efforts to standardize histopathology practice through the development of guidelines, the interpretation of morphology is still hampered by subjectivity. We here describe Pathology Imagebase, a novel mechanism for establishing an international standard for the interpretation of pathology specimens.Methods and resultsThe International Society of Urological Pathology (ISUP) established a reference image database through the input of experts in the field. Three panels were formed, one each for prostate, urinary bladder and renal pathology, consisting of 24 international experts. Each of the panel members uploaded microphotographs of cases into a non‐public database. The remaining 23 experts were asked to vote from a multiple‐choice menu. Prior to and while voting, panel members were unable to access the results of voting by the other experts. When a consensus level of at least two‐thirds or 16 votes was reached, cases were automatically transferred to the main database. Consensus was reached in a total of 287 cases across five projects on the grading of prostate, bladder and renal cancer and the classification of renal tumours and flat lesions of the bladder. The full database is available to all ISUP members at www.isupweb.org. Non‐members may access a selected number of cases.ConclusionsIt is anticipated that the database will assist pathologists in calibrating their grading, and will also promote consistency in the diagnosis of difficult cases.
Variety‐based discrimination of apple juices by an electronic nose and gas chromatography–mass spectrometry
Authors: Wu Hao , Wang Jianguo , Yue Tianli , Yuan Yahong 
Published: July 2017

SummaryThe variety of raw material plays a crucial role in the quality and authenticity of fruit juices and juice products. To characterise and classify apple juices according to variety on the basis of their volatile compounds, electronic nose (EN) and gas chromatography–mass spectrometry (GC‐MS) were applied to detect the apple juices prepared by eight different varieties. The EN was used to analyse the mixture of volatile compounds as a whole and enabled rapid classification of juice samples when coupled with linear discriminant analysis (LDA). LDA showed a perfect discrimination of apple juices based on varieties. GC‐MS was utilised to illustrate the differences of volatile compounds among juice samples. Identification of volatile compositions and their contents provides useful access to differentiate juices from different varieties.
The Staurocentric Logic of Eberhard Jüngel: Pneumatology and Ecclesiology
Authors: Reinhard Kathryn L. 
Published: July 2017

AbstractEcclesiology and pneumatology remain two areas of Eberhard Jüngel's thought that are repeatedly critiqued as being ‘underdeveloped’ or ‘deficient’ due to his reliance on an Augustinian grammar in describing the Holy Spirit. This article argues for a revised understanding of both Jüngel's trinitarian theology and ecclesiology in light of his commitment to staurocentrism. Jüngel's staurocentric doctrine of God, for which he is so often lauded, is only possible because of the Augustinian grammar he accepts for his pneumatology. Only as the bond of love, the relation between the relations, can the Spirit make clear how it is that the triune God, fully identified with the life of Jesus, can die. Ultimately, Jüngel builds on Augustine's doctrine of the Spirit to demonstrate two distinct, yet interrelated, theological principles: first, that the person of the Spirit is indispensible within the event of God's triune being; and second, that within the church it is the Spirit's personhood, uniquely, which makes possible ecclesial correspondence to God.
Exploring Perceptions of the Food Environment Amongst Congolese, Somalis and Zimbabweans Living in Cape Town
Authors: Hunter‐Adams Jo 
Published: July 2017

AbstractIn low and middle‐income countries, the nutrition transition to highly processed, high‐sugar diets has been extraordinarily rapid. Yet in these same settings, obesity and hunger are often experienced within a single household. As part of a broader study of cross‐border migrants’ experiences of maternal and infant nutrition in Cape Town, in this article I explore the individual and collective meanings associated with foods in a specific migrant context, as well as their connections to changing food environments in Cape Town, South Africa. While there was relative silence over food scarcity, the food environment seemed to present constraints to dietary diversity. The migrants’ views and experiences suggest the relevance of improving the accessibility and affordability of already desirable, nutrient dense foods.
Challenges of connectedness in personal recovery for rural mothers with mental illness
Authors: Hine Rochelle Helena , Maybery Darryl , Goodyear Melinda Jane 
Published: July 2017

AbstractSocial connection is a fundamental human need, but challenging for individuals with characteristics that are socially stigmatized. Parenting with mental illness presents obstacles, as well as opportunities, for connection. In the present study, we examined connectedness within a personal recovery paradigm for rural mothers with a mental illness. In‐depth interviews with 17 mothers with a mental illness, utilizing constructivist grounded theory, resulted in six categories of meaning, including ‘yearning for connection’, ‘connecting intensely’, ‘encountering rejection and exclusion’, ‘choosing isolation’, ‘being known’, and ‘finding peers/helping others’. Women expressed a strong desire for connection, but for many, prior experiences of trauma and rejection created barriers to the development of trust, preventing some women from seeking opportunities for connection. Connectedness to self and significant others, and a broader life meaning and purpose can support and expedite personal recovery from mental illness for rural women. However the factors that contribute to the mental illness might also inhibit the development of trust needed to attain social connection. Increasing connectedness in mothers with mental illness is a complex endeavour requiring concerted focus as distinct from other service‐delivery goals. The perinatal period could be a key time for intervention.
Risk factors for amputation in patients with diabetic foot infection: a prospective study
Authors: Uysal Serhat , Arda Bilgin , Taşbakan Meltem I , Çetinkalp Şevki , Şimşir Ilgın Y , Öztürk Anıl M , Uysal Ayşe , Ertam İlgen 
Published: July 2017

AbstractThere is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of DFIs. In this study, we aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation in patients with DFI using standard scoring procedures.We prospectively studied 379 patients with DFI. The variables were analysed using logistic analysis. A total of 126 cases (33·2%) underwent amputation. The odds ratios in the amputation model were 3·09 for osteomyelitis (P < 0·001), 4·90 for arterial stenosis (AS) (P < 0·001), 3·67 for the history of DFI (P = 0·001), 2·47 for ulcer duration >60 days (P = 0·001), 3·10 for ulcer depth > 15 mm (P < 0·001) and 10·28 for fungal DFI (P = 0·015).In this study, the unusual result of well‐known literature was fungal DFI as an independent risk factor for amputation in patients with DFI.
The universal, collaborative and dynamic model of specialist and advanced nursing and midwifery practice: A way forward?
Authors: O'Connor Laserina , Casey Mary , Smith Rita , Fealy Gerard M , Brien Denise O' , O'Leary Denise , Stokes Diarmuid , McNamara Martin S , Glasgow Mary Ellen , Cashin Andrew 
Published: July 2017

Aims and objectivesTo inform and guide the development of a future model of specialist and advanced nursing and midwifery practice.BackgroundThere is a sizable body of empirical literature supporting the unique contributions of specialist and advanced practice roles to health care. However, there is very little international evidence to inform the integration of a future model for advanced or specialist practice in the Irish healthcare system.DesignA qualitative study was conducted to initiate this important area of inquiry.MethodsPurposive sampling was used to generate a sample of informants (n = 15) for the interviews. Nurses and midwives working in specialist and advanced practice and participants from other areas such as legislative, regulatory, policy, medicine and education were included in the sampling frame.ResultsArguments for a new model of specialist and advanced practice were voiced. A number of participants proposed that flexibility within specialist and advanced practitioner career pathways was essential. Otherwise, there existed the possibility of being directed into specialised “silos,” precluding movement to another area of integrated practice. Future specialist and advanced practice education programmes need to include topics such as the development of emotional and political intelligence.ConclusionThe contribution of specialist and advanced practice roles to the health service includes providing rapid access to care, seamless patient flow across services, early discharge and lead coordinator of the patient's care trajectory. There was a recommendation of moving towards a universal model to cultivate specialist and advanced nurse and midwife practitioners.Relevance to clinical practiceThe model design has Universal application in a range of contexts “U.” It is Collaborative in its inclusivity of all key stakeholders “C.” The model is Dynamic pertinent to accommodating movement of nurses and midwives across health continua rather than plateauing in very specialised “silos” “D.”
Tailoring of the Tell‐us Card communication tool for nurses to increase patient participation using Intervention Mapping
Authors: van Belle Elise , Zwakhalen Sandra M G , Caris Josien , Van Hecke Ann , Huisman‐de Waal Getty , Heinen Maud 
Published: July 2017

Aims and objectivesTo describe the tailoring of the Tell‐us Card intervention for enhanced patient participation to the Dutch hospital setting using Intervention Mapping as a systematic approach.BackgroundEven though patient participation is essential in any patient‐to‐nurse encounter, care plans often fail to take patients’ preferences into account. The Tell‐us Card intervention seems promising, but needs to be tailored and tested before implementation in a different setting or on large scale.DesignDescription of the Intervention Mapping framework to systematically tailor the Tell‐us Card intervention to the Dutch hospital setting.MethodsIntervention Mapping consists of: (i) identification of the problem through needs assessment and determination of fit, based on patients and nurses interviews and focus group interviews; (ii) developing a logic model of change and matrices, based on literature and interviews; (iii) selection of theory‐based methods and practical applications; (iv) producing programme components and piloting; (v) planning for adoption, implementation and sustainability; and (vi) preparing for programme evaluation.ResultsKnowledge, attitude, outcome expectations, self‐efficacy and skills were identified as the main determinants influencing the use of the Tell‐us Card. Linking identified determinants and performance objectives with behaviour change techniques from the literature resulted in a well‐defined and tailored intervention and evaluation plan.ConclusionsThe Tell‐us Card intervention was adapted to fit the Dutch hospital setting and prepared for evaluation. The Medical Research Council framework was followed, and the Intervention Mapping approach was used to prepare a pilot study to confirm feasibility and relevant outcomes.Relevance to clinical practiceThis article shows how Intervention Mapping is applied within the Medical Research Council framework to adapt the Tell‐us Card intervention, which could serve as a guide for the tailoring of similar interventions.
Navigating and negotiating information and support: Experiences of first‐time mothers
Authors: Aston Megan , Price Sheri , Monaghan Joelle , Sim Meaghan , Hunter Andrea , Little Victoria 
Published: July 2017

Aims and objectivesTo examine how first‐time mothers in Nova Scotia identified and prioritised their own postpartum needs and where they went for information and support, inclusive of informal or formal programmes and services, social media, family and friends.BackgroundThe early postpartum period is an exciting, yet stressful life experience for first‐time mothers. Mothers have often turned to families, friends and healthcare professionals for support and information; however, these social networks look differently today due to changes in institutional policies and postpartum healthcare practices, as well as the emergence of online resources and networks. There is currently limited understanding of how online resources have shifted mothers social networking practices and the degree to which programmes and resources are currently meeting the needs of mothers and families.MethodsData were collected through focus group interviews in rural and urban Nova Scotia communities (n = 19) and online electronic interviews (n = 18). Data were analysed using feminist poststructuralism and discourse analysis to understand issues of inclusion and health equity for mothers and how relations of power were negotiated by first‐time mothers in their search for support and information.ResultsMost participants were savvy as they critiqued, compared, navigated and negotiated advice and information from various sources, including health professionals, family, friends and online forums. However, they unanimously wanted face‐to‐face support with other mothers and healthcare professionals. Participants enacted their agency to critically analyse information and support to ensure it matched their own beliefs, values and practices.ConclusionsIt is important to understand first‐time mothers’ practices and need for face‐to‐face support, as well as a need for further research with more diverse or marginalised demographics of mothers.
QUANTITATIVE EMPIRICAL RESEARCH IN MARXIST POLITICAL ECONOMY: A SELECTIVE REVIEW
Authors: Basu Deepankar 
Published: July 2017

AbstractThis paper surveys quantitative empirical research in some key areas of Marxist political economy. Following an introductory section on the value controversy, the paper surveys quantitative empirical research on the following topics: (a) Marxist national accounts, (b) classical‐Marxist theory of relative prices, (c) probabilistic political economy, (d) profitability analysis and (e) classical‐Marxian theories of growth and technical change. I end by highlighting two important puzzles in the extant literature.
Dendrobium nobile Lindl. alkaloids regulate metabolism gene expression in livers of mice
Authors: Xu Yun-Yan , Xu Ya-Sha , Wang Yuan , Wu Qin , Lu Yuan-Fu , Liu Jie , Shi Jing-Shan 
Published: July 2017

Abstract

Objectives
In our previous studies, Dendrobium nobile Lindl. alkaloids (DNLA) has been shown to have glucose-lowering and antihyperlipidaemia effects in diabetic rats, in rats fed with high-fat diets, and in mice challenged with adrenaline. This study aimed to examine the effects of DNLA on the expression of glucose and lipid metabolism genes in livers of mice.

Methods
Mice were given DNLA at doses of 10–80 mg/kg, po for 8 days, and livers were removed for total RNA and protein isolation to perform real-time RT-PCR and Western blot analysis.

Key findings
Dendrobium nobile Lindl. alkaloids increased PGC1α at mRNA and protein levels and increased glucose metabolism gene Glut2 and FoxO1 expression. DNLA also increased the expression of fatty acid β-oxidation genes Acox1 and Cpt1a. The lipid synthesis regulator Srebp1 (sterol regulatory element-binding protein-1) was decreased, while the lipolysis gene ATGL was increased. Interestingly, DNLA increased the expression of antioxidant gene metallothionein-1 and NADPH quinone oxidoreductase-1 (Nqo1) in livers of mice. Western blot on selected proteins confirmed these changes including the increased expression of GLUT4 and PPARα.

Conclusions
DNLA has beneficial effects on liver glucose and lipid metabolism gene expressions, and enhances the Nrf2-antioxidant pathway gene expressions, which could play integrated roles in regulating metabolic disorders.
Chemometric evaluation of hypericin and related phytochemicals in 17 in vitro cultured Hypericum species, hairy root cultures and hairy root-derived transgenic plants
Authors: Nigutová Katarína , Kusari Souvik , Sezgin Selahaddin , Petijová Linda , Henzelyová Jana , Bálintová Miroslava , Spiteller Michael , Čellárová Eva 
Published: July 2017

Abstract

Objectives
The objective of this study was to ascertain the presence and correlations among eight important secondary metabolites viz. hypericin, pseudohypericin, emodin, hyperforin, rutin, hyperoside, quercetin and quercitrin in different organs of 17 in vitro cultured Hypericum species, along with H. tomentosum and H. tetrapterum hairy root cultures, and hairy root-derived transgenic plants of H. tomentosum.

Methods
Samples were extracted and analysed by LC-MS. The LC-MS data were subjected to chemometric evaluations for metabolite profiling and correlating the phytochemical compositions in different samples.

Key findings
Hypericin, pseudohypericin and their proposed precursor emodin were detected in various levels in the leaves of eight Hypericum species. The highest content of hypericins and emodin was found in H. tetrapterum, which contains the studied secondary metabolites in all plant organs. A significant positive correlation between hypericins and emodin was observed both by principal component analysis (PCA) and multidimensional scaling (MDS), indicating the role of emodin as a possible precursor in the biosynthetic pathway of hypericins. Flavonoids were found in all tested plant organs except roots of H. pulchrum. The hairy roots lacked hypericin, pseudohypericin, emodin, hyperforin and rutin. However, the hairy root-derived transgenic plants showed a significant increase in flavonoids.

Conclusions
This study broadens knowledge about the phytochemical composition of selected in vitro cultured Hypericum species, compared to that of hairy root cultures and hairy root-derived transgenic plants.
In silico and in vitro prediction of gastrointestinal absorption from potential drug eremantholide C
Authors: Caldeira Tamires G , Saúde-Guimarães Dênia A , Dezani André B , Serra Cristina Helena dos Reis , de Souza Jacqueline 
Published: July 2017

Abstract

Objectives
Analysis of the biopharmaceutical properties of eremantholide C, sesquiterpene lactone with proven pharmacological activity and low toxicity, is required to evaluate its potential to become a drug.

Methods
Preliminary analysis of the physicochemical characteristics of eremantholide C was performed in silico. Equilibrium solubility was evaluated using the shake-flask method, at 37.0 °C, 100 rpm during 72 h in biorelevant media. The permeability was analysed using parallel artificial membrane permeability assay, at 37.0 °C, 50 rpm for 5 h. The donor compartment was composed of an eremantholide C solution in intestinal fluid simulated without enzymes, while the acceptor compartment consisted of phosphate buffer.

Key findings
Physicochemical characteristics predicted in silico indicated that eremantholide C has a low solubility and high permeability. In-vitro data of eremantholide C showed low solubility, with values for the dose/solubility ratio (ml): 9448.82, 10 389.61 e 15 000.00 for buffers acetate (pH 4.5), intestinal fluid simulated without enzymes (pH 6.8) and phosphate (pH 7.4), respectively. Also, it showed high permeability, with effective permeability of 30.4 × 10−6 cm/s, a higher result compared with propranolol hydrochloride (9.23 × 10−6 cm/s).

Conclusions
The high permeability combined with its solubility, pharmacological activity and low toxicity demonstrate the importance of eremantholide C as a potential drug candidate.
Gearing effects of the patella (knee extensor muscle sesamoid) of the helmeted guineafowl during terrestrial locomotion
Authors: Allen V. R. , Kambic R. E. , Gatesy S. M. , Hutchinson J. R. 
Published: July 2017

AbstractHuman patellae (kneecaps) are thought to act as gears, altering the mechanical advantage of knee extensor muscles during running. Similar sesamoids have evolved in the knee extensor tendon independently in birds, but it is unknown if these also affect the mechanical advantage of knee extensors. Here, we examine the mechanics of the patellofemoral joint in the helmeted guineafowlNumida meleagrisusing a method based on muscle and tendon moment arms taken about the patella's rotation centre around the distal femur. Moment arms were estimated from a computer model representing hindlimb anatomy, using hip, knee and patellar kinematics acquired via marker‐based biplanar fluoroscopy from a subject running at 1.6 ms−1on a treadmill. Our results support the inference that the patella ofNumidadoes alter knee extensor leverage during running, but with a mechanical advantage generally greater than that seen in humans, implying relatively greater extension force but relatively lesser extension velocity.