bluuebunny/crossref_metadata_2025_split huggingface dataset:
Missing Domains of Lung Transplant Patient Selection
Authors: Blumenthal Nancy P. , Petty Michael G. , McCorkle Ruth 
Published: November 2016

The goal of consistent, predictable, and improved outcomes has continued to elude the scientific community in the 30 years since lung transplantation became the procedure of choice for patients with terminal, nonmalignant lung disease. Background: Although there is consensus regarding disease-specific indications for lung transplant, ambiguity remains regarding how patient-specific attributes should influence lung transplant candidacy. This study had 3 aims (1) to establish the missing domains of the interdisciplinary assessment of the lung transplant candidate, (2) to have these domains validated by an international panel of lung transplant experts, and (3) to recommend the next step for inclusion of these domains into the lung transplant candidate selection process. Methods: Three levels of evidence were reviewed. A search for standards and guidelines, a comprehensive literature review, and a validation of domains by experts were conducted. Results: Seven domains of patient attributes were identified as relevant to lung transplant patient selection: cognitive performance, frailty, psychological factors, self-efficacy, social support, quality of life, and sociodemographic factors. Within each domain, several elements were identified to be incorporated in the process of patient assessment. Conclusion: Assessment of the missing domains and elements should be incorporated into the interdisciplinary lung transplant evaluation process. Standardized recognition and reporting of the patient-specific attributes will inform the work of individual transplant programs and the international transplant community. Further study is needed to associate these patient attributes with transplant outcomes. Improved understanding is needed regarding how nurses assess lung transplant candidates and how they communicate their findings within interdisciplinary settings.
Predictors of Liver Transplant Patient Survival
Authors: Pruinelli Lisiane , Monsen Karen A. , Gross Cynthia R. , Radosevich David M. , Simon György J. , Westra Bonnie L. 
Published: November 2016

Objective: Liver transplantation is a costly and risky procedure, representing 25 050 procedures worldwide in 2013, with 6729 procedures performed in the United States in 2014. Considering the scarcity of organs and uncertainty regarding prognosis, limited studies address the variety of risk factors before transplantation that might contribute to predicting patient’s survival and therefore developing better models that address a holistic view of transplant patients. This critical review aimed to identify predictors of liver transplant patient survival included in large-scale studies and assess the gap in risk factors from a holistic approach using the Wellbeing Model and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Data Source: Search of the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, and PubMed from the 1980s to July 2014. Study Selection: Original longitudinal large-scale studies, of 500 or more subjects, published in English, Spanish, or Portuguese, which described predictors of patient survival after deceased donor liver transplantation. Data Extraction: Predictors were extracted from 26 studies that met the inclusion criteria. Data Synthesis: Each article was reviewed and predictors were categorized using a holistic framework, the Wellbeing Model (health, community, environment, relationship, purpose, and security dimensions). Conclusions: The majority (69.7%) of the predictors represented the Wellbeing Model Health dimension. There were no predictors representing the Wellbeing Dimensions for purpose and relationship nor emotional, mental, and spiritual health. This review showed that there is rigorously conducted research of predictors of liver transplant survival; however, the reported significant results were inconsistent across studies, and further research is needed to examine liver transplantation from a whole-person perspective.
Efficacy of granulocyte and monocyte apheresis for antibiotic-refractory pouchitis after proctocolectomy for ulcerative colitis: an open-label, prospective, multicentre study
Authors: Yamamoto Takayuki , Tanaka Toshiaki , Yokoyama Tadashi , Shimoyama Takahiro , Ikeuchi Hiroki , Uchino Motoi , Watanabe Toshiaki 
Published: November 2016

Background: Granulocyte and monocyte apheresis (GMA) has shown therapeutic efficacy in active ulcerative colitis (UC). We thought that in patients with pouchitis after proctocolectomy for UC, GMA might produce immunological effects in the intestinal mucosa, and improve clinical symptoms. This prospective study was to evaluate the efficacy of GMA for antibiotic-refractory pouchitis after proctocolectomy for UC. Methods: A total of 13 patients with pouchitis disease activity index (PDAI) > 7 unresponsive to 2 weeks of antibiotic therapy were included. All patients received 10 GMA sessions at 2 sessions/week over 5 consecutive weeks. The primary endpoints were response (a decrease of ⩾3 points in the PDAI) and remission (PDAI < 4). Secondary endpoints included reduction of white blood cells (WBCs), C-reactive protein (CRP), faecal markers (calprotectin and lactoferrin), reduction of the PDAI endoscopic subscore, and GMA safety. Results: The median PDAI score was significantly decreased from 11 (range, 9–15) at entry to 9 (range, 6–13) after the GMA therapy ( p = 0.02). A total of six patients (46%) responded to the treatment, but none achieved remission. The median endoscopic subscore (maximum: 6) was 5 (range, 4–6) at entry and 5 (range, 1–6) after the treatment ( p = 0.10). None of the laboratory markers (WBCs, CRP, faecal calprotectin and lactoferrin) significantly changed during the treatment. Transient adverse events (AEs) were observed in two patients (15%), dyspnoea in one and headache in one. The AEs were not serious, and all patients completed the 10 GMA sessions. Conclusions: GMA has a good safety profile, but its efficacy appears to be limited in the management of chronic refractory pouchitis. However, a large controlled study should be conducted to evaluate the efficacy of GMA therapy in patients with pouchitis at an earlier clinical stage, before the disease has become refractory to conventional medical therapy.
Percutaneous sacroplasty for the management of painful pathologic fracture in a multiple myeloma patient: Case report and review of the literature
Authors: Dmytriw AA , Talla K , Smith R 
Published: November 2016

Percutaneous kyphoplasty has a well-established role in the treatment of pathologic fractures in patients with multiple myeloma. Despite this, there is a scarcity of literature surrounding its use and efficacy in the sacrum. We present a case of successful symptom resolution in a patient with painful sacral fracture following sacroplasty, and review the existing literature. An 81-year-man with multiple myeloma presented to the hematology/oncology clinic with a history of excruciating pain while seated. The impact of this pain on his quality of life subjectively was rated to be particularly high. Computed tomography of the sacrum confirmed the presence of pathologic fracture within the S1 and S2 vertebrae. Under fluoroscopic guidance, polymethyl methacrylate (PMMA) bone cement was injected via 11-gauge needles using an anterior-oblique approach. No immediate post-procedural complications occurred, such as foraminal extravasation or venous injection. The patient reported himself to be pain-free 1 day following the procedure, and this remains the case to date at 2 years of follow-up. Sacroplasty is technically feasible and can provide durable relief of symptoms in patients with painful pathologic fractures of the sacrum. It is likely underused and can offer tremendous benefit to myeloma patients.
Comparison of Goals of Care Between Hemodialysis Patients and Their Health Care Providers
Authors: Lefkowitz Ariel , Henry Blair , Bottoms Jennifer , Myers Jeffery , Naimark David M. J. 
Published: November 2016

Background: Patient-centered care requires knowledge of patients’ goals of care (GoC) on the part of health care providers (HCPs). Whether HCPs caring for in-center hemodialysis patients meet this criterion is uncertain. Objective: We designed and conducted a GoC survey among patients and HCPs within a single in-center hemodialysis (ICHD) program to determine whether HCPs have an understanding of their patients’ GoC. Design: This was a prospective comparative quantitative survey study. Setting: The study included a single Canadian maintenance ICHD center. Participants: These included hemodialysis patients and their primary nephrologists, nurses, social workers, pharmacists, and dietitians. Methods and Measurements: Two surveys, one for patients and another for primary HCPs, were designed, piloted, and administered. For each participating patient, HCPs consisted of the primary nephrologist, nurse, social worker, pharmacist, and dietitian. Surveys included questions pertaining to 7 GoC themes. Patient-HCP agreement on the importance of each domain individually and the most important domain overall was assessed with kappa statistics. Factors influencing agreement were assessed with logistic regression in a secondary analysis. Results: A total of 173 patients were invited to participate, of whom 137 (79%) completed surveys. Fifty HCPs completed 623 corresponding surveys: 132 by physicians, 112 by nurses, 126 by pharmacists, 127 by social workers, and 126 by dietitians. A total of 70.1% and 78.8% of patients agreed with the importance of and would feel comfortable having GoC discussions, respectively, with their HCPs; 42.7% of physicians reported not having provided prognostic information to the corresponding patient. Patient-HCP agreement regarding GoC was poor (all κ < .25, all P values > .05). In adjusted analyses, only patients choosing “Be Cured” as the most important GoC was significantly associated with poorer HCP-patient agreement than expected (odds ratio, 0.04; 95% confidence interval, 0.01-0.18). Limitations: This is a single-center study involving only ICHD patients. Conclusions: HCP perceptions of GoC did not agree with patients’ reported GoC. This study suggests the need for the design and validation of interventions to improve HCPs’ understanding of their patients’ GoC.
Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis
Authors: Jain Amrita , Beutel Oliver , Ebell Katharina , Korneev Sergey , Holthuis Joost C. M. 
Published: November 2016

ABSTRACT
A deregulation of ceramide biosynthesis in the endoplasmic reticulum (ER) is frequently linked to induction of mitochondrial apoptosis. Although in vitro studies suggest that ceramides might initiate cell death by acting directly on mitochondria, their actual contribution to the apoptotic response in living cells is unclear. Here, we have analyzed the consequences of targeting the biosynthetic flow of ceramides to mitochondria using a ceramide transfer protein (encoded by COL4A3BP) equipped with an OMM anchor, mitoCERT. Cells expressing mitoCERT import ceramides into mitochondria and undergo Bax-dependent apoptosis. Apoptosis induction by mitoCERT was abolished through (i) removal of its ceramide transfer domain, (ii) disruption of its interaction with VAMP-associated proteins (VAPs) in the ER, (iii) addition of antagonistic CERT inhibitor HPA12, (iv) blocking de novo ceramide synthesis and (v) targeting of a bacterial ceramidase to mitochondria. Our data provide the first demonstration that translocation of ER ceramides to mitochondria specifically commits cells to death and establish mitoCERT as a valuable new tool to unravel the molecular principles underlying ceramide-mediated apoptosis.
A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level
Authors: Koh Siang-Boon , Mascalchi Patrice , Rodriguez Esther , Lin Yao , Jodrell Duncan I. , Richards Frances M. , Lyons Scott K. 
Published: November 2016

ABSTRACT
The fluorescence ubiquitination-based cell cycle indicator (FUCCI) is a powerful tool for use in live cells but current FUCCI-based assays have limited throughput in terms of image processing and quantification. Here, we developed a lentiviral system that rapidly introduced FUCCI transgenes into cells by using an all-in-one expression cassette, FastFUCCI. The approach alleviated the need for sequential transduction and characterisation, improving labelling efficiency. We coupled the system to an automated imaging workflow capable of handling large datasets. The integrated assay enabled analyses of single-cell readouts at high spatiotemporal resolution. With the assay, we captured in detail the cell cycle alterations induced by antimitotic agents. We found that treated cells accumulated at G2 or M phase but eventually advanced through mitosis into the next interphase, where the majority of cell death occurred, irrespective of the preceding mitotic phenotype. Some cells appeared viable after mitotic slippage, and a fraction of them subsequently re-entered S phase. Accordingly, we found evidence that targeting the DNA replication origin activity sensitised cells to paclitaxel. In summary, we demonstrate the utility of the FastFUCCI assay for quantifying spatiotemporal dynamics and identify its potential in preclinical drug development.
Systematic Review of the Studies Examining the Impact of the Interactive Whiteboard on Teaching and Learning: what we do learn and what we do not
Authors: Kyriakou Artemis , Higgins Steve 
Published: November 2016

<p>This systematic review focuses on the impact of Interactive Whiteboards (IWBs) on teaching and learning. Learning is interpreted through a Vygotskian constructivist lens, emphasizing quality through dialogic interaction. Classroom interactions and achievement in standardized tests are considered formative and summative assessment tools, respectively. Thus, our aim was to investigate whether the IWB technology had any effect on teaching and learning, reflected in standardized forms of testing or in-classroom quality measures. An online search through Proquest and FirstSearch resulted in sixteen studies of diverse methodologies. Qualitative synthesis of quantitative data indicated that IWBs have not raised the levels of pupils’ achievement and do not necessarily impact the quality of classroom learning. More longitudinal studies should focus on particular subjects taught, the age of pupils and particular type(s) of use. Overall, quality teaching is an important condition for improved learning, which does not necessarily result from IWB use. However, there is a general consensus across all studies that learning can be facilitated and improved through the use of IWB. Synchronizing theory with technological applications seems to be key in answering such assumptions positively. More importantly, concerns are raised regarding the unfolded relation between achievement and classroom interaction.</p>
A inserção do Profissional de Educação Física nos Núcleos de Apoio a Saúde da Família: visão dos profissionais
Authors: Ferreira Talitha , Cipolotti Mariana , Marques Bruna , Miranda Maria 
Published: November 2016

Criado em 2008, o Núcleo de Apoio à Saúde da Família (NASF) surgiu com a finalidade de aumentar as ações da Estratégia de Saúde da Família (ESF) por meio de sua atuação integrada com as equipes de saúde e todas as redes de serviço. O objetivo deste estudo foi analisar a percepção de Profissionais de Educação Física (PEF) inseridos no NASF sobre as funções e a efetividade da intervenção multiprofissional nas equipes no Município de São Paulo. Participaram do estudo oito profissionais com experiência no NASF (atualmente inseridos no NASF ou que já trabalharam nessas equipes). Foi utilizada uma entrevista semiestruturada para obter as informações, analisadas por meio de análise de conteúdo. Observou-se que os participantes trouxeram informações positivas a respeito do NASF, mostrando como são realizadas as atividades e quais suas funções no grupo. Os resultados apresentados por esta pesquisa apontam que a inserção do PEF é relevante nas equipes NASF, pois representam uma área de conhecimento e intervenção habilitada para desenvolver ações e programas de educação em saúde, sendo a promoção à atividade física e modos de vida saudáveis, parte constituinte deste processo. Porém, foram demonstrados lacunas e desafios a serem enfrentados por PEF no município de São Paulo para a consolidação da sua inserção nessas equipes.
Book review supplement
Authors: Rea Karen , Wainwright Paul , Kenrick Maria , Farrington Andy , Jones Kath , MacAlister Lunette , Davison Peter 
Published: November 2016

Case Studies in Law and Nursing Clinical supervision and mentorship in nursing Psychology for Nurses: Theory and Practice Adult Psychological Problems – An Introduction Death at Birth (Video) Portfolio Development and Profiling for Nurses Guidelines for Clinical Nursing Practices Related to a Nursing Model (2nd edn)
Health visiting an elderly couple
Authors: Millard Jeanette 
Published: November 2016

Care study Mr and Mrs H have lived in their own home, a three-bedroomed, traditional-style semi-detached house, since they were married 60 years ago. After Mr H was diagnosed as having Parkinson's disease in 1988 they converted their front living room into a bedroom, which they share. They have two children, a son and a daughter. A second son, the youngest, tragically died suddenly less than 12 months ago at the age of 54 from an unsuspected cancer of the lung. Their son and daughter live locally and visit fairly regularly, along with the grandchildren. Mr and Mrs H keep in close contact with their daughter-in-law, especially since the death of their son, and she is a regular visitor to their home. Since his diagnosis, Mr H has found that certain tasks, such as dressing, which he had once found easy, have become more difficult and take longer. He walks with the typical gait of sufferers of Parkinson’ disease. Mrs H has cared lovingly for her husband since his illness was diagnosed and initially claimed that she did not need any additional help. I chose the Neuman Systems Model (1982) to assess Mr and Mrs H's healthcare needs. From the assessment, I was able to identify ‘stressors’ in their environment. Mr and Mrs H readily accepted my perceptions of their problems and together we negotiated some short-, medium-, and long-term goals requiring health visiting intervention. Subsequently the short- and medium-term goals have been met and the stressors eliminated. Mr and Mrs H are pleased with the results and are coping well and much of their anxiety has been resolved. They now receive ongoing support from a health visitor and other members of the primary healthcare team to enable them to live independently in the community, which was one of the long-term objectives of the study.
Studi Perbandingan Teknik Sinkronisasi Waktu untuk Sistem Mobile OFDM
Authors: Suyoto Suyoto 
Published: November 2016

OFDM (Orthogonal Frequency Division Multiplexing) adalah teknik modulasi cocok untuk aplikasi delay spread yang tinggi. Namun kinerja OFDM sangat sensitif terhadap kesalahan sinkronisasi waktu. Pada tulisan ini, pengkajian terhadap beberapa algoritma untuk sinkronisasi waktu di sistem komunikasi OFDM pada model kanal multipath ITU Vehicular dilakukan. Dari hasil analisis, terpilih empat algoritma sinkronisasi waktu yang mempunyai ukuran pewaktu yang bersifat impulsif untuk dievaluasi kinerjanya dalam menghitung waktu kedatangan simbol OFDM. Simulasi dilakukan dengan mempertimbangkan pengaruh SNR (Sinyal to Noise Ration) dan CIR (Channel Impulse Response). Kinerja dari algoritma diukur dengan MSE (Mean Squared Error) dari offset timing point. Hasil simulasi menunjukkan bahwa teknik konvensional (teknik autocorrelation dan crosscorrelation) tidak cukup untuk sistem dengan kondisi kanal dengan delay spread yang cukup tinggi. Teknik konvensional yang digabungkan dengan teknik perubahan statistik pada korelator mempunyai kinerja yang lebih baik pada kondisi kanal dengan delay spread yang cukup tinggi.
Web-Based Decision Support Systems Application of Stock Recommendation Using Bayesian Methods
Authors: Sevani Nina , Ariesta Maria 
Published: November 2016

We propose an application that can support traders by providing recommendation about the right stock transaction. The expected impact from this application is to reduce the risk of loss, even achieve the maximum profit for traders who use this application. Recommendation that resulted by application is based on Bayesian methods calculation and four technical analysis indicators that most commonly used by stock experts, i.e. Bollinger Bands, Moving Average Convergence Divergence (MACD), Relative Strength Index (RSI), and Stochastic Oscillator. Methodology used in this paper consists of data collection, data analysisa, application design, implementation, and testing. From the results of application testing, the accuracy of the application is 87,37%.
A COMMOLIZAÇÃO DO DIREITO POSITIVO, O ATIVISMO JUDICIAL E A CRISE DO ESTADO
Authors: Bodnar Zenildo , Cruz Paulo Márcio 
Published: November 2016

O presente artigo trata de analisar e discutir a crise de algumas das teorias modernas sobre o Direito e o Estado, principalmente a tripartição clássica de poderes e o protagonismo atual do Poder Judiciário, o que permite estabelecer relações teóricas sobre a aproximação e/ou a colaboração entre as famílias jurídicas denominadas de Common Law e o Civil Law a partir do Ativismo Judicial.
Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation
Authors: Abzhanova Diana , Godymchuk Anna , Gusev Alexander , Kuznetsov Denis 
Published: November 2016

AbstractThe growing production and use of nickel (Ni) nanopowders with low biopersistence makes dissolution and accumulation degree in a body an important parameters needed for the risk assessment of nanoparticles. We propose an experimental approach for rapid determination of the dissolution degree of nanoscale (77 nm) and ultrafine (275 nm) Ni particles in synthetic biological solutions. It has been shown that after 2 h of exposure to simulating saliva and lysosomal liquid the dissolution degree of nanoparticles can reach 30 and 60 wt.%, respectively. With decreasing of the particle’s size, they are characterized by increased solubility in saliva and the pulmonary tract; and the particles completely dissolve in 24 h. There was an attempt to predict the potential extent of accumulation of nickel compounds in the human body with particles entering the body by saliva or with breathing: with 3.8 times size decrease the probability of nickel accumulation in a body can rise in 3.5 times.