bluuebunny/crossref_metadata_2025_split huggingface dataset:
μ‐Opioid agonists for preventing emergence agitation under sevoflurane anesthesia in children: a meta‐analysis of randomized controlled trials
Authors: Tan Yuan , Shi Yisa , Ding Hui , Kong Xiangbin , Zhou Haijiao , Tian Jinhui 
Published: November 2015

SummaryBackgroundEmergence agitation (EA) is an adverse effect after sevoflurane anesthesia in pediatric patients. The effectiveness of prophylactic μ‐opioid agonists fentanyl, remifentanil, sufentanil, and alfentanil in preventing EA is debatable.MethodsA literature search was conducted to identify clinical trials that observed the effect of μ‐opioid agonists fentanyl, remifentanil, sufentanil, and alfentanil on preventing EA in pediatric patients under sevoflurane anesthesia. The statistical software RevMan 5.3 was used for meta‐analysis. Data from each study were combined using the relative ratio (RR), weighted mean differences, and their associated 95% confidence intervals. I2 was used to evaluate heterogeneity. Subgroup analysis was conducted to investigate the possible influences of patient age, adenotonsillectomy, premedication, N2O, propofol, and regional block/local anesthetics on preventing EA with prophylactic administration of μ‐opioid agonists. Publication bias was checked using funnel plots and Begg's test.ResultsThis meta‐analysis showed the inclusion of 19 randomized controlled trials with 1528 patients (857 patients received μ‐opioid agonists therapy and 671 patients had placebo). The pooled data indicated that prophylactic μ‐opioid agonists fentanyl, remifentanil, sufentanil, and alfentanil significantly decreased the incidence of EA [RR = 0.49 (0.38, 0.64), I2 = 42%, P = 0.04; RR = 0.57 (0.33, 0.99), I2 = 37%, P = 0.19; RR = 0.18 (0.08, 0.39), I2 = 0%, P = 0.98; and RR = 0.56 (0.40, 0.78), I2 = 6%, P = 0.34, respectively]. All subgroup analyses strengthened the proof for lower incidence of EA under sevoflurane anesthesia after fentanyl administration. A possibility of publication bias was detected in the fentanyl group.ConclusionsThis meta‐analysis suggested that prophylactic μ‐opioid agonists fentanyl, remifentanil, sufentanil, and alfentanil could significantly decrease the incidence of EA under sevoflurane anesthesia in children compared to placebo. Considering the limitations of the included studies, more clinical studies are required.
Lower Resting State Heart Rate Variability Relates to High Pain Catastrophizing in Patients with Chronic Whiplash‐Associated Disorders and Healthy Controls
Authors: Koenig Julian , De Kooning Margot , Bernardi Anthony , Williams DeWayne P. , Nijs Jo , Thayer Julian F. , Daenen Liesbeth 
Published: November 2015

AbstractVagally mediated heart rate variability (vmHRV) is widely respected as a psychophysiological measure of emotion regulation capacity and serves as a readily available index of executive brain areas that exert an inhibitory influence on subcortical structures. Pain catastrophizing (PC) is conceptualized as the tendency to misinterpret and exaggerate pain‐related situations that may be threatening. Chronic pain patients show lower vmHRV and higher PC. Previously, no study has investigated the association of PC and vmHRV. We examined the association of PC and vmHRV in a sample of patients with chronic whiplash‐associated disorders (WAD, n = 30) and healthy controls (n = 31). Patients with WAD showed lower vmHRV, indexed by high‐frequency HRV (effect size, Cohen's d = 0.442), and greater PC (d = 0.815). Zero‐order and partial correlations controlling for age and sex revealed that vmHRV and PC are inversely related. The results provide evidence for a psychophysiological mechanism underlying PC, in particular in chronic pain patients.
Comparison of prophylactic use of intravenous immunoglobulin versus Pentaglobin® in pediatric patients after hematopoietic stem cell transplantation
Authors: Azık Fatih , Bayram Cengiz , Erkoçoğlu Mustafa , Tezer Hasan , Yazal Erdem Arzu , Işık Pamir , Avcı Zekai , Özbek Namık , Tavil Betül , Tunc Bahattin 
Published: November 2015

AbstractThere are few studies evaluating the use of IgM‐enriched IVIG (Pentaglobin®) in HSCT recipients. This study aimed to compare the efficacy of prophylactic use of IVIG versus prophylactic use of Pentaglobin® within the first 100 days after allogeneic HSCT. We performed a prospective, randomized study of the use of prophylactic IVIG versus prophylactic use of Pentaglobin® in patients after allogeneic HSCT. The first dose of IVIG or Pentaglobin® was given before conditioning regimen and after transplant was given on day +1, +8, +15, and +22. And then, it was given if IgG level was below 400 mg/dL. Twenty‐seven patients in IVIG group and 32 patients in Pentaglobin® group were included in the study. There were no significant differences in the duration of neutropenia, hospitalization, fever, and in the number of pyrexial episode, septicemia, bacteremia, local infection, CMV infection, acute GVHD, VOD, and adverse events between the IVIG group and Pentaglobin® group. Randomized placebo‐controlled trials are needed to conclude that utilization of IVIG or Pentaglobin® has no beneficial effect in HSCT.
Comparison of toxicity following different conditioning regimens (busulfan/melphalan and carboplatin/etoposide/melphalan) for advanced stage neuroblastoma: Experience of two transplant centers
Authors: Elborai Yasser , Hafez Hanafy , Moussa Emad A. , Hammad Mahmoud , Hussein Hany , Lehmann Leslie , Elhaddad Alaa 
Published: November 2015

AbstractThe outcome for advanced neuroblastoma has improved with combined modality therapy: induction chemotherapy, surgery, and consolidation with high‐dose chemotherapy/autologous HSCT, followed by local radiation, cisretinoic acid, and recently antibody therapy. In the United States, the most common conditioning regimen is CEM, while in Europe/Middle East, Bu/Mel has been widely used; it remains unclear which regimen has the best outcome. Assess renal, hepatic, and infectious toxicity through Day+100 in 2 different regimens. Retrospective comparison between CEM‐DFCHCC Boston and Bu/Mel‐ CCHE‐57357. Thirty‐five patients, median age 4, in Boston (2007–2011) and 38 patients, median age 3, in Cairo (2009–2011). Renal toxicity; creatinine was significantly higher in CEM than Bu/Mel: 57% (median day+90) vs. 29% (median>day+100), p = 0.004. One CEM patient died from renal dialysis at day+19. Hepatic toxicity was significantly higher in CEM than Bu/Mel: 80% (median day+26) vs. 58% (median day+60), p = 0.04. In infectious complications with CEM 14%, bacteremia (n = 4) and fungemia (n = 1), 3 had culture‐negative sepsis requiring vasopressors. With Bu/Mel 18%, bacteremia (n = 7), none required pressors, p = 0.4. Bu/Mel was associated with less acute hepatic and renal toxicity and thus may be preferable for preserving organ functions.
Antileishmanial and immunomodulatory effects of the essential oil from Tetradenia riparia (Hochstetter) Codd
Authors: Demarchi Izabel Galhardo , Terron Mariana de Souza , Thomazella Mateus Vailant , Mota Camila Alves , Gazim Zilda Cristiani , Cortez Diógenez Aparício Garcia , Aristides Sandra Mara Alessi , Silveira Thaís Gomes Verzignassi , Lonardoni Maria Valdrinez Campana 
Published: November 2015

SummaryCutaneous leishmaniasis usually presents therapeutic resistance to antimonials, and the existing therapies for leishmaniasis have many adverse effects and toxicity. Natural products may be regarded as possible candidates for alternative leishmaniasis treatment. The plant Tetradenia riparia has shown promise for the treatment of infectious diseases in folk medicine. We evaluated the antileishmanial activity of an essential oil from T. riparia (TrEO) and the modulatory effects of TrEO on cytokine modulation by peritoneal fluid cells that were infected with L. (L.) amazonensis. Peritoneal fluid cells were infected with Leishmania and incubated with TrEO (30 ng/mL) for 3, 6, and 24 h. Cytokines were screened using semi‐quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) and flow cytometry. Antileishmanial activity was evaluated at 24 h by microscopic counting and quantitative PCR (qPCR). TrEO treatment induced the death of 50% of Leishmania amastigotes (indicated by microscopic counting) and 91% of the parasite load (indicated by qPCR). TrEO inhibited some of the most critical cytokines for parasite growth and the establishment of infection, including granulocyte‐macrophage colony‐stimulating factor, interleukin‐4 (IL‐4), IL‐10, and tumour necrosis factor. The parasite inhibited interferon‐γ and IL‐12, and TrEO blocked this inhibition, indicating that these cytokines are critical for activating mechanisms associated with the death and elimination of the parasite. These results suggest that TrEO may be an alternative leishmaniasis therapy when considering its antileishmanial and immunomodulatory activity.
Flooding affects the development of Plasmodiophora brassicae in Arabidopsis roots during the secondary phase of infection
Authors: Gravot A. , Lemarié S. , Richard G. , Lime T. , Lariagon C. , Manzanares‐Dauleux M. J. 
Published: November 2015

Clubroot, a disease of Brassicaceae species, is caused by the soilborne pathogen Plasmodiophora brassicae. High soil water content was previously described to favour the motility of zoospores and their penetration into root cells. In this study, the effect of irrigation regimes on clubroot development during the post‐invasive secondary phase of infection was investigated. Three irrigation regimes (low, standard, high) were tested on two Arabidopsis accessions, Col‐0 (susceptible) and Bur‐0, a partially resistant line. In Col‐0, clubroot symptoms and resting spore content were higher under the ‘low irrigation’ regime than the other two regimes, thus enhancing the phenotypic contrast between the two Arabidopsis accessions. Clubroot severity under high and low irrigation regimes was evaluated in near‐isogenic lines derived from a Col‐0 × Bur‐0 cross, to assess the effect of soil moisture on the expression of each of four quantitative trait loci (QTL) controlling partial resistance. The presence of the Bur‐0 allele at the QTL PbAt5.2 resulted in reduced severity only under low irrigation, whereas the Bur‐0 allele at QTL PbAt5.1 was associated with partial resistance only under high irrigation. QTL PbAt4 reduced the number of resting spores in infected roots, but was not associated with reduced clubroot symptoms. The results indicated that soil moisture could have consequences for the secondary phase of clubroot development, depending on plant genotype. Future genetic studies may benefit from using combinations of watering conditions during the secondary stage of infection, thus opening up the possibility of identifying genetic factors expressed under specific environmental conditions.
Obduction triggered by regional heating during plate reorganization
Authors: Hässig Marc , Rolland Yann , Duretz Thibault , Sosson Marc 
Published: November 2015

AbstractThe reason for obduction, or tectonic transport of oceanic lithosphere onto continents, is investigated by two‐dimensional thermo‐mechanical numerical modelling based on the geology of the Anatolia–Lesser Caucasus ophiolites. Heating of the oceanic domain and extension induced by far‐field plate kinematics appear to be essential for the obduction of ~80‐Ma‐old oceanic crust over distances exceeding 200 km. Heating of the oceanic lithosphere by mantle upwelling is evidenced by a thick alkaline volcanic series emplaced on top of the oceanic crust 10–20 Ma before obduction, at the onset of Africa–Eurasia convergence. Regional heating reduced the negative buoyancy and strength of the magmatically old lithosphere. Extension facilitated the propagation of obduction by reducing the mantle lithosphere thickness, which led to the exhumation of eclogite‐free continental crust previously underthrusted beneath the ophiolites. This extensional event is ascribed to far‐field plate kinematics resulting from renewed Neotethys oceanic subduction beneath Eurasia.
Firm R&D, Processing Trade and Input Trade Liberalisation: Evidence from Chinese Firms
Authors: Tian Wei , Yu Miaojie 
Published: November 2015

AbstractThis paper examines the impact of input trade liberalisation on firm R&D activity by taking China's accession to the WTO as a quasi‐natural experiment. Different from ordinary imports, processing imports in China enjoy zero tariffs and are not affected by input trade liberalisation due to the WTO accession. The paper uses disaggregated firm‐level production data and transaction‐level trade data to perform difference‐in‐difference analysis by taking processing import firms as a control group. An intensive empirical search shows that after China's accession to the WTO, input trade liberalisation fostered firm R&D significantly. The findings are robust to different measures and various empirical specifications.
Cladistic analysis of Aradidae (Insecta, Heteroptera) based on morphological and molecular characters
Authors: Marchal Lorène , Guilbert Eric 
Published: November 2015

In this study, we present for the first time a cladistic analysis of the subfamilies of Aradidae, using molecular and morphological characters. Eighty‐three taxa, including 79 species representing eight subfamilies, are treated. The analyses were performed using 72 morphological characters and approximately 1650 bp corresponding to three molecular loci (CO1, 16S and 28S). Characters were analysed using parsimony and Bayesian methods. Based on the combined analyses, we find support for the monophyly of Aradidae, including the subfamilies Aradinae, Aneurinae, Calisiinae, Isoderminae, and Mezirinae and the paraphyly of Prosympiestinae and Chinamyersiinae. In all analyses, Prosympiestinae includes Isoderminae. The Termitaphididae were not found sister to the Aradidae in the Aradoidea.
PARAMETER IDENTIFICATION OF DEPTH-DEPTH-MATCHING ALGORITHM FOR LIVER FOLLOWING
Authors: Watanabe Kaoru , Yagi Masahiro , Ota Kento , Onishi Katsuhiko , Koeda Masanao , Nankaku Shigeki , Noborio Hiroshi , Kon Masanori , Matsui Kousuke , Kaibori Masaki 
Published: November 2015

We proposed a depth-depth-matching algorithm as a fast motion transcription algorithm from a real liver to a virtual liver in a surgical navigation. The real is always captured by 3D depth camera, and the virtual is represented by a polyhedron with STL format via DICOM captured by MRI/CT. In our algorithm, we firstly compare a 2D depth image in a real world and the Z-buffer in a virtual world, and secondly search 3 translation and 3 rotation movements by matching both depth images in order for a virtual liver to move against a real liver. In this paper, the performance of our algorithm is ascertained in a PC simulation by changing several parameters and/or the evaluation function.
OPTICAL EMISSION SPECTROSCOPY ANALYSIS OF ATMOSPHERIC PLASMA JET PLUME ON BACTERIA INACTIVATION
Authors: Saad Nor Aimi , Zaaba SK , Mustaffa M.T. , Zakaria A. , Md Nor Roslan , Shahriman AB , Akitsu Tetsuya 
Published: November 2015

In this paper, an atmospheric plasma jet plasma plume generated using Helium gas was investigated for reactive plasma species. The method of investigation is by using Optical Emission Spectroscopy analysis. Observation of the emission spectrum enables understanding of the influence of reactive species inside plasma plume to microbial inactivation process. The reactive species in plasma plume were detected using spectrometer without presence of bacteria. Escherichia coli and Methicillin-resistant staphylococcus aureus were used as inactivation targets. Bacteria were cultured in 10 Colony Forming Unit per milliliter in single colony and exposed to plasma at different time. It is found that, both bacteria were inactivated at 180 seconds. The result of emission line spectrum showed the presence of nitrogen and oxygen between line 300 nm until 700 nm. Nitrogen and oxygen are involved in oxidation process which is known as Reactive Nitrogen Species and Reactive Oxygen Species. These species are main key in bacteria inactivation.
A PRELIMINARY STUDY ON DETECTION OF LUNG CANCER CELLS BASED ON VOLATILE ORGANIC COMPOUNDS SENSING USING ELECTRONIC NOSE
Authors: Thriumani Reena , Jeffreea Amanina Iymia , Zakaria Ammar , Hasyim Yumi Zuhanis Has-Yun , Helmy Khaled Mohamed , Omar Mohammad Iqbal , Adom Abdul Hamid , Shakaff Ali Yeon , Kamarudin Latifah Munirah 
Published: November 2015

This paper proposes a preliminary investigation on the volatile production patterns generated from three sets of in-vitro cancerous cell samples of headspace that contains volatile organic compounds using the electronic nose system. A commercialized electronic nose consisting of 32 conducting polymer sensors (Cyranose 320) is used to analyze the three classes of signals which are lung cancer cells grown in media, breast cancer cells grown in media and the blank media (without cells). Neural Network (PNN) based classification technique is applied to investigate the performance of an electronic nose (E-nose) system for cancerous lung cell classification.
STATIC RESPONSE ON LIME COLUMN AND GEOTEXTILE ENCAPSULATED LIME COLUMN (GELC) STABILISED MARINE CLAY UNDER VERTICAL LOAD
Authors: Yah Chong Siaw , Kassim Khairul Anuar , Ping Chiet Kenny Tiong , Soon Tan Choy 
Published: November 2015

Marine clay, which is widely encountered in coastal area in Malaysia, is a problematic base material. Previous researchers reported that deep lime stabilisation can significantly improve clay. However, insufficient confining pressure from surrounding soil normally lead to the inferior performance on the upper part of column such as column head crushing and larger deformation on the surrounding soil at toppart of column. Therefore, geotextile encapsulation was proposed for lime column in this study. Static response and stress distribution are essential in the understanding on behaviour of columnar stabilised soil under vertical load. Multi stages loading tests were conducted onPontian marine clay, with and without geotextile encapsulation.Stress concentration ratio (σmid/ σsoil) was examined in each loading stage, where it is defined as stress on column (σmid) divided by stress on surrounding soil (σsoil). The samples were cured for 14, 28 and 56 days before tested. It was found that stress concentration ratio was dependent on column materials strength properties and applied loading. Geotextile encapsulation increased the stress concentration ratio on lime column.Stress concentration increment effect by geotextile encapsulation was further enhanced by the confining pressure of surrounding soil; however, the effect reduced with increase of applied loading. Higher stress concentration ratio indicated lesser load on surrounding soil and therefore the soil settlement could be reduced
MODELLING THE EFFECT OF WIND FORCES ON LANDSLIDE OCCURRENCE IN BUDUDA DISTRICT, UGANDA
Authors: Nelson Okello , Kassim Azman , Yunusa Gambo Haruna , Abu Talib Zaihasra 
Published: November 2015

The hilly area of Bududa District, in Eastern Uganda has suffered heavily from landslide occurrence, making the local populace unsafe. Although the area is well covered by vegetation, a catastrophic landslide occurred on the 26th June, 2012 and killed more than 18 people and wiped out the nearby community. The fallen trees due wind effect prior to the landslide coupled with intense rainfall are believed to trigger that landslide. Therefore, the effect of commonly known causative factor of rainfall and an uncommon landslide causal factor of wind forces on landslide occurrence were investigated in this study. The geometry of the modelled slope consists of 111 m height, 480 m length, and an inclination of 21°. Finite element seepage software, Seep/W and limit equilibrium software, Slope/W were used for modelling the landslide occurrence using five (5) slope models with and without additional shear strength in form of tree root cohesion. Each of the slope models was subjected to four failure criteria (FC). The first two failure criteria (FC1 and FC2) are assigned for group of tree along the slope (FC1) and a single tree at the middle (FC2) of the modelled slope. The other two failure criteria (FC3 and FC4) are assigned for the modelled slope with rainfall infiltration alone and rainfall plus several tree weights, respectively. The wind speed during which the landslide occurred was depicted using Beaufort wind scale 11 and was applied to the appropriate models. The results obtained show that with eucalyptus trees of Diameters at Breast Heights (DBH) of 25 cm, a minimum factor of safety (FOS) of 1.012 and 1.273 were recorded for FC2 in Slope model 1 and slope model 4 with and without increased cohesion, respectively. This shows an increase in the FOS of 23.81%. However, when the DBH was increased to a maximum of 60 cm (i.e. in slope model 3), the safety of the modelled slope diminishes and the FOS reduces to 0.601 for FC2 on the 25th day, without cohesion, just some hours before the fateful day of the 26th June 2012. This FOS remained below 1.0 (0.800 to 0.601) for FC2 with roots cohesion, although a gain in the FOS of 33.11% was realized. Hence, it can be concluded that the uncommon natural causative factors of wind have a great influence on landslide occurrence in the hilly areas of Bududa district
SEGMENT’S JOINT IN PRECAST TUNNEL LINING DESIGN
Authors: Jusoh Siti Norafida , Mohamad Hisham , Marto Aminaton , Mohd Yunus Nor Zurairahetty , Kasim Fauziah 
Published: November 2015

Tunnel lining design requires an interactive approach as the design is not merely about the strength, but how much the tunnel allows to flexure to overcome the ground movement. When tunnel interacts with soil, stress from the ground is distributed into the structure. In the case of precast segmental bolted tunnel lining, it is critical to investigate the lining joints reaction, as this affects the overall flexural behaviour of tunnel lining. The objective of this paper is to present a discussion on the mechanics response of segmental tunnel lining affected by the segment’s joint. A short review on research works conducted in recent day on joint effect in segment’s joint in tunnel lining is also presented.
Functionally heterogeneous synaptic vesicle pools support diverse synaptic signalling
Authors: Chamberland Simon , Tóth Katalin 
Published: November 2015

AbstractSynaptic communication between neurons is a highly dynamic process involving specialized structures. At the level of the presynaptic terminal, neurotransmission is ensured by fusion of vesicles to the membrane, which releases neurotransmitter in the synaptic cleft. Depending on the level of activity experienced by the terminal, the spatiotemporal properties of calcium invasion will dictate the timing and the number of vesicles that need to be released. Diverse presynaptic firing patterns are translated to neurotransmitter release with a distinct temporal feature. Complex patterns of neurotransmitter release can be achieved when different vesicles respond to distinct calcium dynamics in the presynaptic terminal. Specific vesicles from different pools are recruited during various modes of release as the particular molecular composition of their membrane proteins define their functional properties. Such diversity endows the presynaptic terminal with the ability to respond to distinct physiological signals via the mobilization of specific subpopulation of vesicles. There are several mechanisms by which a diverse vesicle population could be generated in single presynaptic terminals, including distinct recycling pathways that utilize various adaptor proteins. Several additional factors could potentially contribute to the development of a heterogeneous vesicle pool such as specialized release sites, spatial segregation within the terminal and specialized delivery pathways. Among these factors molecular heterogeneity plays a central role in defining the functional properties of different subpopulations of vesicles.
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