bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic scores as a predictor of oxygenation index in very low‐birthweight infants
Authors: Zuiki Masashi , Asuka Kisho , Hasegawa Tomohiro , Uesugi Madoka , Takada Rei , Yamano Akio , Morimoto Hidechika , Hashiguchi Kanae , Hasegawa Tatsuji , Iehara Tomoko 
Published: September 2024

AbstractBackgroundVery low birthweight infants (VLBWIs) often undergo chest radiographic examinations without standardization or objectivity. This study aimed to assess the association of two radiographic scores, the Brixia and radiographic assessment of lung edema (RALE), with oxygenation index (OI) in ventilated VLBWIs and to determine the optimal cutoff values to predict hypoxic respiratory severity.MethodsVLBWIs who received invasive respiratory support with arterial lines between January 2010 and October 2023 were enrolled in this study (n = 144). The correlation between the Brixia or RALE scores and OI was investigated. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff points of the two radiographic scores for predicting OI values (OI ≥5, ≥10, and ≥15).ResultsThe enrolled infants had a median gestational age of 27 weeks (interquartile range [IQR], 25–28 weeks) and a median birthweight of 855 g (IQR, 684–1003 g). Radiographic scoring methods correlated with the OI (Brixia score: r = 0.79, p < 0.001; RALE score: r = 0.72, p < 0.001). The optimal cutoff points for predicting OI values were as follows: Brixia score: OI ≥5, 10; OI ≥10, 13; OI ≥15, 15; RALE score: OI ≥5, 22; OI ≥10, 31; and OI ≥15, 40.ConclusionsBrixia and RALE scores are useful predictive markers of the oxygenation status in intubated VLBWIs with stable hemodynamics. These scores are easy to use and promising tools for clinicians to identify patients with a higher risk of hypoxic respiratory failure.
Is Liver Transplantation Alone an Effective Treatment for Homozygotic Familial Hypercholesterolemia in Children?
Authors: Yılmaz Dağlı Hatice , Artan Reha , Civan Dudu Duygu , İnan Aydemir Nurel , Yılmaz Aygen 
Published: September 2024

ABSTRACTAimTo examine the long‐term results and treatment effectiveness of liver transplantation (LT) in the treatment of homozygous familial hypercholesterolemia (HoFH) in children and adolescents.MethodPatients who underwent LT due to HoFH between 2007 and 2023 were included in the study. The patients' demographic data, clinical findings, preoperative and postoperative laboratory examinations, transplantation complications, and postoperative disease courses were evaluated.ResultsThere were five boys with an average age of 6.2 (median: 6, range 4–10) years in the study. The average total cholesterol level of the patients before transplantation was 923 (median: 950, range: 780–1002) mg/dL and the average LDL‐cholesterol level was 864 (median: 852, range: 770–957) mg/dL. No patients died of transplant‐related complications. After an average follow‐up of 9.2 (median: 9, range: 1.5–16) years, the average total cholesterol level of the patients was 197 (median: 164, range: 137–359) mg/dL, and the average LDL‐cholesterol level was 138 (median: 92, range: 85–313) mg/dL. Four (80%) patients developed atherosclerotic cardiovascular disease during follow‐up, and two (40%) died of this cause.ConclusionLT in the treatment of HoFH did not help our patients reach the target LDL‐cholesterol level after transplantation and did not prevent the development of cardiovascular disease. Therefore, LT alone is not curative in the treatment of HoFH.
Risk Factors of Post‐Traumatic Stress in Pediatric Solid Organ Transplant Recipients
Authors: Hind Tatsuma , Robillard Julie , Armstrong Kathryn , Guttman Orlee , Blydt‐Hansen Tom D. 
Published: September 2024

ABSTRACTBackgroundLife with end‐stage organ failure is accompanied by an accumulation of traumatic medical or surgical experiences. Despite recovery after solid organ transplantation (SOT), many children and adolescents develop post‐traumatic stress symptoms (PTSS). PTSS remain underappreciated as a major comorbidity in SOT programs, despite their association with decreased quality of life.MethodsWe conducted a retrospective, cross‐sectional study of 86 pediatric SOT recipients (17 heart, 44 kidney, and 25 liver) to evaluate potential determinants of PTSS. Trauma symptoms were measured by the Child Trauma Screening Questionnaire (CTSQ). Demographic, baseline, and contemporaneous factors were tested for independent association with CTSQ scores.ResultsThe median post‐transplant CTSQ score was 2 (IQR 1–4), and 22% were identified as high risk (score ≥5) for PTSD. Higher CTSQ scores were independently associated with the number of ICU days within the previous 12 months, the number of medications (complexity), and involvement with foster care in the primary model (R2 [adj.] = 0.26). The addition of the Family Impact Module improved the overall model (R2 [adj.] = 0.33), wherein higher family functioning was independently associated with lower CTSQ scores. An exploratory analysis of pre‐transplant patients (n = 34) found a median pre‐transplant CTSQ of 2 (IQR 1–6), suggesting that PTSS are onset before transplant and persist afterward.ConclusionsPTSS are highly prevalent in the SOT population. Risk factors include recent adverse medical experiences and complexity, whereas family stability may be protective. Additional research is needed to improve early ascertainment and support for patients at high risk of developing PTSS throughout their transplant journey.
Delay impacts of ant nests on plant reproductive phenology in a temperate steppe
Authors: Zhou Z. , Hu M. , Ru J. , Yang S. , Zhang Y. , Wang X. , Chen J. , Cui Y. 
Published: September 2024

Abstract
Increasing ant abundance associated with climate warming has been observed in temperate ecosystems. However, how enhanced ant activity affects plant development and phenology remains unclear.
In this study, individuals of a perennial forb (Potentilla tanacetifolia) during flowering with and without an ant (Proformica) nest were marked to explore the impacts of ant nests on plant growth and phenology in a temperate steppe on the Mongolian Plateau.
Ant nests delayed the start and end flowering dates simultaneously and, consequently, had no effect on flowering duration. However, presence of an ant nest postponed the fruiting date of individuals. Nests further increased numbers of aborted flowers and thus decreased fruit set. These observations suggest that the delayed flowering phenology disrupted synchrony between plant reproduction and pollinators and thus reduced pollination efficiency under ant nests.
Given the increasing abundance of ants with rising temperatures under climate warming, plant delayed reproductive phenology and reduced reproductive output will potentially have negative consequences for plant fitness and plant–arthropod interactions, with consequent impacts on resistance and resilience of perennial species in temperate steppes under climate change.
Perturbed conformal invariance and Mei adiabatic invariants of the generalized perturbed Hamiltonian systems with additional terms
Authors: Rehman Haseeb Ur , Feroze Tooba 
Published: September 2024

AbstractThis study investigates the relationship between perturbed conformal invariance and Mei symmetry in the generalized perturbed Hamiltonian systems with additional terms. A necessary and sufficient condition is derived to determine whether perturbed conformal invariance can be considered an approximate Mei symmetry. Furthermore, the Mei adiabatic invariants are also obtained. Lastly, an example is presented to demonstrate the key findings.
Understanding the Interactions Between Loading, Pain Dynamics, and Imaging Characteristics for Osgood Schlatter: A Cross‐Sectional Study
Authors: Holden S. , Lyng K. , Olesen J. L. , Sørensen L. B. , Rathleff M. S. 
Published: September 2024

ABSTRACTOsgood Schlatter's disease (OSD) is characterized by pain at the tibial tuberosity provoked during knee‐loading activities, and is common in adolescent athletes. The aim of this study was to characterize clinical, pain and ultrasound imaging characteristics in participants with OSD compared to controls. This cross‐sectional study included adolescents diagnosed with OSD and matched controls. Following baseline evaluation including ultrasound, participants completed the following aggravating activities in a randomized order: single‐leg isometric knee hold, single‐leg squat, single‐leg vertical jump, hopping, running, cutting, lunges, and walking. Participants rated pain intensity on a numeric rating scale (0–10; no pain to worst pain imaginable) and localization during activities. We included 35 participants with OSD (48.5% females, age 13.0 [SD 1.5]) and 21 controls (47.6% females, age 13.4 [SD1.4]). Doppler signal was more prevalent in OSD participants at the tendon (77% vs. 30%) and tuberosity (29% vs. 10%). Tendon thickness was greater in OSD at distal (mean difference = 4.5 mm 95% CI 1.5–7.5) and proximal sites (mean difference = 4.2 95% CI 0.1–8.3). Aggravating activities induced higher pain in OSD. The greatest differences between OSD and control were the dynamic single‐leg squat (mean difference = 4.2 (95% CI 3.22–5.1)). Pain was localized at the tibial tuberosity and patellar tendon during activities. Sex, sports participation, bilateral pain, and Doppler were associated with greater pain during aggravating activities. Single‐leg activities loading the tibial tuberosity through the tendon appear to provoke OSD‐related pain more than other sports specific movements. This may be useful to guide adolescents on which activities are likely to aggravate pain.
Advocates forSTEMeducation: Developing advocacy identity inSTEMteacher leadership
Authors: Velasco Richard Carlos L. , Pullen Kendra Renae , Remington Jeff D. 
Published: September 2024

AbstractScience, technology, engineering, and mathematics (STEM) teacher advocacy is a particular skillset within STEM teacher leadership, but little is known about how STEM teacher leaders develop their identity as advocates for STEM education. To glean a more nuanced and deeper understanding of developing advocate identity among STEM teacher leaders, we conducted a duoethnographic study to critically reflect on our lived experiences as STEM teacher leaders engaged in advocacy. Drawing upon identity theory to frame our study, we co‐developed and individually responded to a set of questions and prompts that critically interrogated our experiences, leading toward identifying as advocates for STEM education. Multiple subsequent critical discussions about our responses led to a recorded dialogic conversation, which acted as our site of research. Emergent themes from duoethnographic analysis revealed having increased awareness of STEM education policies and their impacts, recognizing injustices affecting marginalized communities, and acknowledging systemic barriers preventing community voices in policymaking helped to strengthen our advocacy identities. The dialogue also emphasized the importance of reaching out to communities to understand needs when developing policy recommendations. We conclude the study by making recommendations to support STEM teacher leaders interested in engaging in advocacy at the individual classroom, school, and district levels.
Teaching the Religions of the World in an Age of Polarization
Authors: Smith Leslie Dorrough , Ramey Steven 
Published: September 2024

ABSTRACTTeaching a course on religions of the world is challenging, especially considering the cogent critiques of that paradigm and the history of its construction. In our courses and text, we have employed a strategy comparing different representations of a single religion to help students develop analytical and critical thinking skills. Within this approach, we employ a functionalist methodology that addresses how each representation of a religion empowers particular groups as well as how the practices and ideas within each religion function. Organizing a course and textbook in this fashion coordinates with assignments that ask students to compare the construction and functions of different representations of the same religion, thus reinforcing to students that no single description of a religion is complete or free from individual and group interests.
MsMIOX2, encoding a MsbZIP53‐activated myo‐inositol oxygenase, enhances saline–alkali stress tolerance by regulating cell wall pectin and hemicellulose biosynthesis in alfalfa
Authors: Guo Weileng , Chen Jiaxin , Liu Lei , Ren Yuekun , Guo Rui , Ding Yang , Li Ying , Chai Juqi , Sun Yuanqing , Guo Changhong 
Published: September 2024

SUMMARYAlfalfa is one of the most widely cultivated forage crops worldwide. However, soil salinization restricts alfalfa growth and development and affects global productivity. The plant cell wall is the first barrier against various stresses. Therefore, elucidating the alterations in cell wall architecture is crucial for stress adaptation. This study aimed to clarify the impact of myo‐inositol oxygenase 2 (MsMIOX2) on cell wall pectin and hemicellulose biosynthesis under saline–alkali stress and identify the upstream transcription factors that govern MsMIOX2. MsMIOX2 activation induced cell wall pectin and hemicellulose accumulation under saline–alkali stress. The effects of MsMIOX2 in saline–alkali tolerance were investigated by characterizing its overexpression and RNA interference lines. MsMIOX2 overexpression positively regulated the antioxidant system and photosynthesis in alfalfa under saline–alkali stress. MsMIOX2 exhibited myo‐inositol oxygenase activity, which increased polysaccharide contents, facilitated pectin and hemicellulose biosynthesis, and extended the cell wall thickness. However, MsMIOX2 RNA interference decreased cell wall thickness and alleviated alfalfa saline–alkali stress tolerance. In addition, MsbZIP53 was identified as an upstream transcriptional MsMIOX2 regulator by yeast one‐hybrid, electrophoretic mobility shift assay, dual‐luciferase, and beta‐glucuronidase assays. MsbZIP53 overexpression increased MsMIOX2 expression, elevated MIOX activity, reinforced the antioxidant system and photosynthesis, and increased saline–alkali stress tolerance in alfalfa. In conclusion, this study presents a novel perspective for elucidating the molecular mechanisms of saline–alkali stress tolerance in alfalfa and emphasizes the potential use of MsMIOX2 in alfalfa breeding.
Horseshoe effects on equine gait—A systematic scoping review
Authors: Aoun Rita , Takawira Catherine , Lopez Mandi J. 
Published: September 2024

AbstractObjectiveTo provide an overview of available research about effects of horseshoes on equine kinetics and kinematics.MethodsThe terms, “horse/equine,” “hoof,” “shoes/horseshoes,” “kinetics,” and “kinematics” were searched in PubMed, Web of Science, Center for Agriculture and Bioscience International, and United States Department of Agriculture National Agricultural Library for manuscripts from first availability to 2024. Independent reviewers used preferred reporting items for systematic reviews and meta‐analyses guidelines to map and extract evidence‐based data from sources. Metrics included participant demographics, research methods, major findings, and study limitations. Knowledge gaps were also identified.ResultsA total of 46 studies were included. Most utilized non‐lame horses to compare original shoe designs or modifications to unshod or a standard open‐heel shoe. Horse demographics and gait, study design and outcome measures varied widely. Prevalent data collection equipment included force platforms and pressure plates, wearable force measuring technology, and videography. Many studies reported shoeing effects on limb forces and motion, but there was little consensus among unrelated studies. Common limitations included insufficient data resolution, no randomization, small sample size, single breed, and outcome measures specific or unique to the study. Knowledge gaps included data collection from all limbs and the impact of conformation and limb and hoof morphology and health condition on outcomes.ConclusionInformation from manuscripts that met inclusion criteria confirmed distinct, variable effects of shoe characteristics on equine gait parameters.Clinical significanceDetails from published work can serve as resource for clinical decisions and to guide standardization among investigations on shoe configuration effects on equine motion.
Mediating role of specific environmental beliefs in the relationship between general beliefs and water consumption
Authors: Shamim Muhammad Asif , Amlus Mohammad Harith , Jawaid Syed Tehseen 
Published: September 2024

AbstractThis study investigates the impact of general environmental beliefs (GEB) on water consumption behaviour (WCB) and the mediating role of specific environmental beliefs (SEB) in Kuala Lumpur. By administering 1584 surveys via a 5‐point Likert scale questionnaire, the study analyses the influence of utilitarian beliefs (UB) and ecological beliefs (EB) at both the Kuala Lumpur and district levels. The results demonstrate that EB significantly mediates the relationship between GEB and WCB, while UB also plays a significant mediating role. The study highlights practical measures for environmental preservation, such as prioritizing utilitarianism for environmentally beneficial choices, afforestation, waste reduction, reusability and recycling of production materials and ensuring ecological system compatibility for waste disposal.
Informal caregivers’ feeding experiences for children with cancer: a qualitative systematic review protocol
Authors: Kamkhoad Donruedee , Srichalerm Tippawan , Witwaranukool Porawan 
Published: September 2024

Objective:
The objective of this review is to synthesize the experiences of informal caregivers’ feeding practices for children with cancer.

Introduction:
Changes in eating among children with cancer impact their nutritional status, leading to several negative outcomes. In addition to interventions given by health care providers, informal caregivers’ experiences in feeding these children are worth exploring.

Inclusion criteria:
This review will include qualitative studies or the qualitative component of mixed method studies examining informal caregivers’ experiences of feeding children with cancer who are under 18 years of age. Children may be in any phase of the cancer journey, and may be at a health care facility or at home. Studies from any country, published in English or Thai in any year up to the present, will be considered for inclusion.

Methods:
This review will follow the JBI approach for qualitative systematic reviews. A full search strategy for PubMed was developed from an initial limited search of PubMed and CINAHL (EBSCOhost) to identify articles on the topic. The search strategy will be adapted for each database, including Embase (Ovid), PubMed, CINAHL (EBSCOhost), Cochrane Library (CENTRAL), LILACS (BVS), PsycINFO (Ovid), Web of Science Core Collection, Scopus, and ThaiJO (TCI). The reference lists of studies included in the review will be hand-searched for additional studies. Sources of unpublished studies and gray literature will also be searched. Two reviewers will separately screen for eligible studies, perform the critical appraisal, and extract data. They will then synthesize via meta-aggregation and summarize the data. The final synthesized findings will be graded using the ConQual approach to establish confidence in the qualitative research synthesis.

Review registration:
PROSPERO CRD42024501382
ОПТИМИЗАЦИЯ ПОЛУЧЕНИЯ КАЛЛУСНЫХ КУЛЬТУР У РАЗЛИЧНЫХ ВИДОВ RHODIOLA SP.
Authors: Райзер О.Б. , Тагиманова Д.С. , Хапилина О.Н. 
Published: September 2024

В Казахстане произрастает несколько видов Rhodiola sp., широко используемых в официальной и народной медицине. Наиболее известной считается родиола розовая или золотой корень (Rhodiola rosea), в корнях которой выявлены биологически активные вещества, оказывающие сильное стимулирующее воздействие на иммунную систему человека. Глобальный спрос на сырье R.rosea способствует тому, что этот вид стал редким и исчезающим, в Казахстане и других странах вид занесен в Красную книгу. Менее известны другие виды - родиола четырехраздельная (Rhodiola quadrifida) и родиола Семенова (Rhodiola semenowii), которые также обладают рядом полезных свойств, сходных по биологической ценности с родиолой розовой.
Для решения проблемы обеспечения ценным растительным сырьем успешно используются альтернативные биотехнологические методы, основанные на использовании растительных систем in vitro. Системы in vitro обладают многими вычисленными преимуществами: биосинтез безопасных метаболитов в соответствии со стандартами GMP; сохранение природных популяций редких и исчезающих видов растений; независимость от факторов окружающей среды; отсутствие в сырье патогенов, агрохимикатов. В отношении продуцирования БAВ в системах in vitro у ценных видов Rhodiola sp. имеется много успешных примеров с использованием каллусных культур.
С целью получения активно растущих каллусных культур различных видов Rhodiola sp. нами были оптимизированы основные этапы биотехнологии. Для индукции культуры in vitro использовали различного типа экспланты: листья, стебли, апексы побегов, корневищные почки. Листья или листовые пластинки у всех исследуемых видов родиолы являются наиболее предпочтительными эксплантами для каллусообразования. Частота каллусообразования в зависимости от видовой принадлежности и используемых регуляторов роста варьировала от 25% у R.quadrifida до 90% у R.rosea и R.semenowii. При использовании в качестве эксплантов пазушных почек, стеблей, апексов и корневищных почек развитие происходило методом прямого органогенеза, с образованием конгломератов, состоящих из множества адвентивных побегов, которые в дальнейшем могут быть использованы для микроклонального размножения.
Исследования по подбору условий культивирования каллусных тканей родиолы выявили, что максимальный прирост биомассы каллусов происходит на средах Мурасиге и Скуга в присутствии TDZ и NAA, с добавлением 6% сахарозы. Для родиолы четырехраздельной эффективной была среда МС с добавлением 2,4-D, NAA и BAP, содержащая 3% сахарозы. Образование конгломерата адвентивных почек наиболее интенсивно происходило в присутствии фитогормонов зеатина (2 мг/л) и ИУК (0,2 мг/л), частота морфогенеза составила более 80%.
Таким образом, определены оптимальные условия культивирования наиболее перспективных видов Rhodiola sp. для последующей разработки технологии продуцирования БАВ в различных системах in vitro.