bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced-portion entrées in a worksite and restaurant setting: impact on food consumption and waste
Authors: Berkowitz Sarah , Marquart Len , Mykerezi Elton , Degeneffe Dennis , Reicks Marla 
Published: June 2016

AbstractObjectiveLarge portion sizes in restaurants have been identified as a public health risk. The purpose of the present study was to determine whether customers in two different food-service operator segments (non-commercial worksite cafeteria and commercial upscale restaurant) would select reduced-portion menu items and the impact of selecting reduced-portion menu items on energy and nutrient intakes and plate waste.DesignConsumption and plate waste data were collected for 5 weeks before and 7 weeks after introduction of five reduced-size entrées in a worksite lunch cafeteria and for 3 weeks before and 4 weeks after introduction of five reduced-size dinner entrées in a restaurant setting. Full-size entrées were available throughout the entire study periods.SettingA worksite cafeteria and a commercial upscale restaurant in a large US Midwestern metropolitan area.SubjectsAdult worksite employees and restaurant patrons.ResultsReduced-size entrées accounted for 5·3–12·8 % and 18·8–31·3 % of total entrées selected in the worksite and restaurant settings, respectively. Food waste, energy intake and intakes of total fat, saturated fat, cholesterol, Na, fibre, Ca, K and Fe were significantly lower when both full- and reduced-size entrées were served in the worksite setting and in the restaurant setting compared with when only full-size entrées were served.ConclusionsA relatively small proportion of reduced-size entrées were selected but still resulted in reductions in overall energy and nutrient intakes. These outcomes could serve as the foundation for future studies to determine strategies to enhance acceptance of reduced-portion menu items in restaurant settings.
Diet quality and cognitive function in an urban sample: findings from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study
Authors: Wright Regina S , Waldstein Shari R , Kuczmarski Marie Fanelli , Pohlig Ryan T , Gerassimakis Constance S , Gaynor Beatrice , Evans Michele K , Zonderman Alan B 
Published: June 2016

AbstractObjectivePoor diet quality contributes to morbidity, including poor brain health outcomes such as cognitive decline and dementia. African Americans and individuals living in poverty may be at greater risk for cognitive decrements from poor diet quality.DesignCross-sectional.SettingBaltimore, MD, USA.SubjectsParticipants were 2090 African Americans and Whites (57 % female, mean age=47·9 years) who completed two 24 h dietary recalls. We examined cognitive performance and potential interactions of diet quality with race and poverty status using baseline data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Healthy Eating Index-2010 (HEI-2010) scores were calculated and interpreted using federal guidelines. A neurocognitive test battery was administered to evaluate cognitive function over several domains.ResultsLinear regression analyses showed that lower HEI-2010 scores were associated with poorer verbal learning and memory (P<0·05) after adjustment for covariates. Diet quality within the sample was poor. Significant interactions of HEI-2010 and poverty status (allP<0·05) indicated that higher diet quality was associated with higher performance on tests of attention and cognitive flexibility, visuospatial ability and perceptual speed among those below the poverty line. No significant race interactions emerged. Higher diet quality was associated with better performance on two measures of verbal learning and memory, irrespective of race and poverty status.ConclusionsFindings suggest that diet quality and cognitive function are likely related at the population level. Future research is needed to determine whether the association is clinically significant.
The ship, the media, and the world: conceptualizing connections in global history
Authors: Wenzlhuemer Roland 
Published: June 2016

AbstractThe study of transregional connections is central to the field of global history. This article reflects on the idea of connections from a conceptual viewpoint and treats them as mediators. This will be exemplified by studying the spatial and temporal dimensions of transoceanic steamship passages. The lives of crew and passengers did not go on ‘stand-by’ during such a passage. The case of the flight and eventual capture of Hawley Harvey Crippen will serve as a case in point. Suspected of murder in London, Crippen tried to escape to North America by transatlantic steamer. The captain, however, recognized the fugitive and informed both authorities and media. The ship, whose movements across the Atlantic contributed to the establishment of global connections, thus became tightly entangled in a global media landscape, with newspapers and readers from all over the globe focusing their attention on the small shipboard community. Simultaneously, the steamer became a profoundly secluded place for its passengers, who were cut off from the media flurry surrounding them. The article shifts the principal perspective of the murder case from a terracentric notion of history to a more sea-based narrative. It offers a new historical interpretation of the events and at the same time reconsiders the analytical concept of connections in a broader historical context.
Bodies at sea: travelling to Australia in the age of sail
Authors: Pietsch Tamson 
Published: June 2016

AbstractThis article considers the bodily experience of being at sea in the age of sail. Using shipboard diaries written by eight passengers during the high period of free migration to the Australasian colonies, it argues that oceanic journeys disrupted and upended the land-based bodily practices being fashioned in nineteenth-century Britain. At sea, these mechanisms of bodily comportment were rendered fragile and unstable, leaving middle- and working-class bodies alike vulnerable and open to refashioning and reformation. In so doing, it points to the need for scholars to bring together land- and sea-based histories and to historicize and particularize oceanic spaces.
‘This strange little floating world of ours’: shipboard periodicals and community-building in the ‘global’ nineteenth century
Authors: de Schmidt Johanna 
Published: June 2016

AbstractPublishing a newspaper was a popular undertaking for passengers aboard intercontinental vessels during the nineteenth century. Although in almost complete isolation for weeks or even months, many travellers saw the need to issue a regular periodical. This article sheds light on the functions that these publications had for the ships’ on-board communities. On the one hand, passengers used them to inculcate a sentiment of togetherness, no matter how ephemeral their community might initially appear. On the other, the periodicals also served to separate and create boundaries between different groups of individuals aboard. Focusing on these unique historical sources allows us to study the building and dissolving of a community feeling in transit in this era of globalizing intercontinental travel. This article shows that ship newspapers were simultaneously a space for social exchange and a means of establishing social boundaries at sea in an age of increasing global shipboard travel.
Anglo-worlds in transit: connections and frictions across the Pacific
Authors: Steel Frances 
Published: June 2016

AbstractThe emerging cultures of late nineteenth-century steamship mobility can be distinguished broadly by ocean basin and by specific route. In the Pacific, a steamship connection between Sydney and San Francisco was envisaged to forge and sustain strong bonds between regional ‘branches’ of the Anglo-Saxon race. This article moves beyond the rhetorical purchase of assumed affinities, to explore the more layered ways in which difference was articulated in transpacific encounters, and the attendant uncertainties and frictions in these evolving relations. When compared to routes bridging the Indian and Atlantic Oceans, with familiar imperial hierarchies and formalities behind them, British and colonial travellers in the Pacific were frequently unsettled by the more democratic and republican attitudes of the American crews and passengers they encountered. At the same time, Britain’s long-standing supremacy on the high seas provided a benchmark against which American enterprise and power in the Pacific could be assessed and found wanting.
Adaptation and Validation of the Basque Version of the Emotional Creativity Inventory in Higher Education
Authors: Soroa Goretti , Aritzeta Aitor , Balluerka Nekane , Gorostiaga Arantxa 
Published: June 2016

AbstractEmotional creativity is defined as the ability to feel and express emotions in a new, effective and authentic way. There are currently no Basque-language self-report instruments to provide valid and reliable measures of this construct. Thus, this paper describes the process of adapting and validating the Emotional Creativity Inventory (ECI) for the Basque-speaking population. The sample was comprised of 594 higher education students (388 women and 206 men) aged between 18 and 32 years old (Mage= 20.47;SD= 2.48). The Basque version of the ECI was administered along with the TMMS-23, NEO PI-R, and PANAS. The results of exploratory and confirmatory factor analyses on the Basque ECI corroborated the original scale’s three-factor structure (preparedness, novelty, and effectiveness/authenticity). Those dimensions showed acceptable indexes of internal consistency (α= .80, .83, and .83) and temporal stability (r= .70, .69, and .74). The study also provided some evidence of external validity (p< .05) based on the relationships found between emotional creativity and emotional intelligence, personality, affect, and sex. The Basque ECI can be regarded as a useful tool to evaluate perceived emotional creativity during the preparation and verification phases of the creative process.
A stable genetic polymorphism underpinning microbial syntrophy
Authors: Großkopf Tobias , Zenobi Simone , Alston Mark , Folkes Leighton , Swarbreck David , Soyer Orkun S 
Published: June 2016

Abstract
Syntrophies are metabolic cooperations, whereby two organisms co-metabolize a substrate in an interdependent manner. Many of the observed natural syntrophic interactions are mandatory in the absence of strong electron acceptors, such that one species in the syntrophy has to assume the role of electron sink for the other. While this presents an ecological setting for syntrophy to be beneficial, the potential genetic drivers of syntrophy remain unknown to date. Here, we show that the syntrophic sulfate-reducing species Desulfovibrio vulgaris displays a stable genetic polymorphism, where only a specific genotype is able to engage in syntrophy with the hydrogenotrophic methanogen Methanococcus maripaludis. This ‘syntrophic’ genotype is characterized by two genetic alterations, one of which is an in-frame deletion in the gene encoding for the ion-translocating subunit cooK of the membrane-bound COO hydrogenase. We show that this genotype presents a specific physiology, in which reshaping of energy conservation in the lactate oxidation pathway enables it to produce sufficient intermediate hydrogen for sustained M. maripaludis growth and thus, syntrophy. To our knowledge, these findings provide for the first time a genetic basis for syntrophy in nature and bring us closer to the rational engineering of syntrophy in synthetic microbial communities.
Large-scale ordering of nanoparticles using viscoelastic shear processing
Authors: Zhao Qibin , Finlayson Chris E. , Snoswell David R. E. , Haines Andrew , Schäfer Christian , Spahn Peter , Hellmann Goetz P. , Petukhov Andrei V. , Herrmann Lars , Burdet Pierre , Midgley Paul A. , Butler Simon , Mackley Malcolm , Guo Qixin , Baumberg Jeremy J. 
Published: June 2016

AbstractDespite the availability of elaborate varieties of nanoparticles, their assembly into regular superstructures and photonic materials remains challenging. Here we show how flexible films of stacked polymer nanoparticles can be directly assembled in a roll-to-roll process using a bending-induced oscillatory shear technique. For sub-micron spherical nanoparticles, this gives elastomeric photonic crystals termed polymer opals showing extremely strong tunable structural colour. With oscillatory strain amplitudes of 300%, crystallization initiates at the wall and develops quickly across the bulk within only five oscillations. The resulting structure of random hexagonal close-packed layers is improved by shearing bidirectionally, alternating between two in-plane directions. Our theoretical framework indicates how the reduction in shear viscosity with increasing order of each layer accounts for these results, even when diffusion is totally absent. This general principle of shear ordering in viscoelastic media opens the way to manufacturable photonic materials, and forms a generic tool for ordering nanoparticles.
A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
Authors: Jing Maofeng , Guo Baodian , Li Haiyang , Yang Bo , Wang Haonan , Kong Guanghui , Zhao Yao , Xu Huawei , Wang Yan , Ye Wenwu , Dong Suomeng , Qiao Yongli , Tyler Brett M. , Ma Wenbo , Wang Yuanchao 
Published: June 2016

AbstractPhytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.
Rebalancing gene haploinsufficiency in vivo by targeting chromatin
Authors: Fulcoli Filomena Gabriella , Franzese Monica , Liu Xiangyang , Zhang Zhen , Angelini Claudia , Baldini Antonio 
Published: June 2016

AbstractCongenital heart disease (CHD) affects eight out of 1,000 live births and is a major social and health-care burden. A common genetic cause of CHD is the 22q11.2 deletion, which is the basis of the homonymous deletion syndrome (22q11.2DS), also known as DiGeorge syndrome. Most of its clinical spectrum is caused by haploinsufficiency ofTbx1, a gene encoding a T-box transcription factor. Here we show that Tbx1 positively regulates monomethylation of histone 3 lysine 4 (H3K4me1) through interaction with and recruitment of histone methyltransferases. Treatment of cells with tranylcypromine (TCP), an inhibitor of histone demethylases, rebalances the loss of H3K4me1 and rescues the expression of approximately one-third of the genes dysregulated byTbx1suppression. In Tbx1 mouse mutants, TCP treatment ameliorates substantially the cardiovascular phenotype. These data suggest that epigenetic drugs may represent a potential therapeutic strategy for rescue of gene haploinsufficiency phenotypes, including structural defects.
Tenascin-C drives persistence of organ fibrosis
Authors: Bhattacharyya Swati , Wang Wenxia , Morales-Nebreda Luisa , Feng Gang , Wu Minghua , Zhou Xiaodong , Lafyatis Robert , Lee Jungwha , Hinchcliff Monique , Feghali-Bostwick Carol , Lakota Katja , Budinger G. R. Scott , Raparia Kirtee , Tamaki Zenshiro , Varga John 
Published: June 2016

AbstractThe factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like receptors (TLRs) in the pathogenesis of SSc. Here we show the expression, mechanism of action and pathogenic role of endogenous TLR activators in skin from patients with SSc, skin fibroblasts, and in mouse models of organ fibrosis. Levels of tenascin-C are elevated in SSc skin biopsy samples, and serum and SSc fibroblasts, and in fibrotic skin tissues from mice. Exogenous tenascin-C stimulates collagen gene expression and myofibroblast transformation via TLR4 signalling. Mice lacking tenascin-C show attenuation of skin and lung fibrosis, and accelerated fibrosis resolution. These results identify tenascin-C as an endogenous danger signal that is upregulated in SSc and drives TLR4-dependent fibroblast activation, and by its persistence impedes fibrosis resolution. Disrupting this fibrosis amplification loop might be a viable strategy for the treatment of SSc.
CNV analysis in Chinese children of mental retardation highlights a sex differentiation in parental contribution to de novo and inherited mutational burdens
Authors: Wang Binbin , Ji Taoyun , Zhou Xueya , Wang Jing , Wang Xi , Wang Jingmin , Zhu Dingliang , Zhang Xuejun , Sham Pak Chung , Zhang Xuegong , Ma Xu , Jiang Yuwu 
Published: June 2016

AbstractRare copy number variations (CNVs) are a known genetic etiology in neurodevelopmental disorders (NDD). Comprehensive CNV analysis was performed in 287 Chinese children with mental retardation and/or development delay (MR/DD) and their unaffected parents. When compared with 5,866 ancestry-matched controls, 11~12% more MR/DD children carried rare and large CNVs. The increased CNV burden in MR/DD was predominantly due to de novo CNVs, the majority of which (62%) arose in the paternal germline. We observed a 2~3 fold increase of large CNV burden in the mothers of affected children. By implementing an evidence-based review approach, pathogenic structural variants were identified in 14.3% patients and 2.4% parents, respectively. Pathogenic CNVs in parents were all carried by mothers. The maternal transmission bias of deleterious CNVs was further replicated in a published dataset. Our study confirms the pathogenic role of rare CNVs in MR/DD, and provides additional evidence to evaluate the dosage sensitivity of some candidate genes. It also supports a population model of MR/DD that spontaneous mutations in males’ germline are major contributor to the de novo mutational burden in offspring, with higher penetrance in male than female; unaffected carriers of causative mutations, mostly females, then contribute to the inherited mutational burden.
Alpha fetoprotein antagonizes apoptosis induced by paclitaxel in hepatoma cells in vitro
Authors: Zhu Mingyue , Li Wei , Lu Yan , Dong Xu , Chen Yi , Lin Bo , Xie Xieju , Guo Junli , Li Mengsen 
Published: June 2016

AbstractHepatocellular carcinoma (HCC) cell resistance to the effects of paclitaxel has not been adequately addressed. In this study, we found that paclitaxel significantly inhibited the viability of HLE, Bel 7402 and L-02 cells in a dose- and time-dependent manner. HLE cells and L-02 cells resisted the cytotoxicity of paclitaxel when transfected with pcDNA3.1-afp vectors. However, Bel 7402 cell sensitivity to paclitaxel was increased when transfected with alpha fetoprotein (AFP)-siRNA. Bel 7402 cell resistance to paclitaxel was associated with the expression of the “stemness” markers CD44 and CD133. Paclitaxel significantly inhibited growth and promoted apoptosis in HLE cells and L-02 cells by inducing fragmentation of caspase-3 and inhibiting the expression of Ras and Survivin, but pcDNA3.1-afp vectors prevented these effects. However, paclitaxel could not significantly promote the cleavage of caspase-3 or suppress the expression of Ras and Survivin in Bel 7402 cells. Silenced expression of AFP may be synergistic with paclitaxel to restrain proliferation and induce apoptosis, enhance cleavage of caspase-3, and suppress the expression of Ras and Survivin. Taken together, AFP may be an important molecule acting against paclitaxel-inhibited proliferation and induced apoptosis in HCC cells via repressing the activity of caspase-3 and stimulating the expression of Ras and Survivin. Targeted inhibition of AFP expression after treatment with paclitaxel is an available strategy for the therapy of patients with HCC.
Optical diffraction for measurements of nano-mechanical bending
Authors: Hermans Rodolfo I. , Dueck Benjamin , Ndieyira Joseph Wafula , McKendry Rachel A. , Aeppli Gabriel 
Published: June 2016

AbstractWe explore and exploit diffraction effects that have been previously neglected when modelling optical measurement techniques for the bending of micro-mechanical transducers such as cantilevers for atomic force microscopy. The illumination of a cantilever edge causes an asymmetric diffraction pattern at the photo-detector affecting the calibration of the measured signal in the popular optical beam deflection technique (OBDT). The conditions that avoid such detection artefacts conflict with the use of smaller cantilevers. Embracing diffraction patterns as data yields a potent detection technique that decouples tilt and curvature and simultaneously relaxes the requirements on the illumination alignment and detector position through a measurable which is invariant to translation and rotation. We show analytical results, numerical simulations and physiologically relevant experimental data demonstrating the utility of the diffraction patterns. We offer experimental design guidelines and quantify possible sources of systematic error in OBDT. We demonstrate a new nanometre resolution detection method that can replace OBDT, where diffraction effects from finite sized or patterned cantilevers are exploited. Such effects are readily generalized to cantilever arrays and allow transmission detection of mechanical curvature, enabling instrumentation with simpler geometry. We highlight the comparative advantages over OBDT by detecting molecular activity of antibiotic Vancomycin.
Environmentally friendly power generator based on moving liquid dielectric and double layer effect
Authors: Huynh D. H. , Nguyen T. C. , Nguyen P. D. , Abeyrathne C. D. , Hossain Md. S. , Evans R. , Skafidas E. 
Published: June 2016

AbstractAn electrostatic power generator converts mechanical energy to electrical energy by utilising the principle of variable capacitance. This change in capacitance is usually achieved by varying the gap or overlap between two parallel metallic plates. This paper proposes a novel electrostatic micro power generator where the change in capacitance is achieved by the movement of an aqueous solution of NaCl. A significant change in capacitance is achieved due to the higher than air dielectric constant of water and the Helmholtz double layer capacitor formed by ion separation at the electrode interfaces. The proposed device has significant advantages over traditional electrostatic devices which include low bias voltage and low mechanical frequency of operation. This is critical if the proposed device is to have utility in harvesting power from the environment. A figure of merit exceeding 10000(108μW)/(mm2HzV2) which is two orders of magnitude greater than previous devices, is demonstrated for a prototype operating at a bias voltage of 1.2 V and a droplet frequency of 6 Hz. Concepts are presented for large scale power harvesting.