bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nationwide Experience With Off‐Label Use of Interleukin‐1 Targeting Treatment in Familial Mediterranean Fever Patients
Authors: Akar Servet , Cetin Pınar , Kalyoncu Umut , Karadag Omer , Sari Ismail , Cınar Muhammed , Yilmaz Sedat , Onat Ahmet Mesut , Kisacik Bunyamin , Erden Abdulsamet , Balkarli Ayse , Kucuksahin Orhan , Oner Sibel Yilmaz , Senel Soner , Tufan Abdurrahman , Direskeneli Haner , Oksuz Ferhat , Pehlivan Yavuz , Bayindir Ozun , Keser Gokhan , Aksu Kenan , Omma Ahmet , Kasifoglu Timucin , Unal Ali Ugur , Yildiz Fatih , Balci Mehmet Ali , Yavuz Sule , Erten Sukran , Ozgen Metin , Sayarlıoglu Mehmet , Dogru Atalay , Yildirim Gozde , Oner Fatma Alibaz , Tezcan Mehmet Engin , Pamuk Omer Nuri , Onen Fatos 
Published: October 2017

ObjectiveApproximately 30–45% of patients with familial Mediterranean fever (FMF) have been reported to have attacks despite colchicine treatment. Currently, data on the treatment of colchicine‐unresponsive or colchicine‐intolerant FMF patients are limited; the most promising alternatives seem to be anti–interleukin‐1 (anti–IL‐1) agents. Here we report our experience with the off‐label use of anti–IL‐1 agents in a large group of FMF patients.MethodsIn all, 21 centers from different geographical regions of Turkey were included in the current study. The medical records of all FMF patients who had used anti–IL‐1 treatment for at least 6 months were reviewed.ResultsIn total, 172 FMF patients (83 [48%] female, mean age 36.2 years [range 18–68]) were included in the analysis; mean age at symptom onset was 12.6 years (range 1–48), and the mean colchicine dose was 1.7 mg/day (range 0.5–4.0). Of these patients, 151 were treated with anakinra and 21 with canakinumab. Anti–IL‐1 treatment was used because of colchicine‐resistant disease in 84% and amyloidosis in 12% of subjects. During the mean 19.6 months of treatment (range 6–98), the yearly attack frequency was significantly reduced (from 16.8 to 2.4; P < 0.001), and 42.1% of colchicine‐resistant FMF patients were attack free. Serum levels of C‐reactive protein, erythrocyte sedimentation rate, and 24‐hour urinary protein excretion (5,458.7 mg/24 hours before and 3,557.3 mg/24 hours after) were significantly reduced.ConclusionAnti–IL‐1 treatment is an effective alternative for controlling attacks and decreasing proteinuria in colchicine‐resistant FMF patients.
Electrical Imaging: Investigating Cellular Function at High Resolution
Authors: Zeck Günther , Jetter Florian , Channappa Lakshmi , Bertotti Gabriel , Thewes Roland 
Published: October 2017

AbstractElectrical imaging of extracellular potentials reveals the activity of electrogenic cells and of networks thereof over several orders of magnitude, both in space and time. On a spatial scale, electrical activity propagates in nanometer‐sized nerve fibers (axons, dendrites), which connect cells in a biological network over several millimeters. On a temporal scale, changes of the extracellular potential caused by action potentials occur on a sub‐millisecond scale, while network activity may be modulated over seconds. Here, different electrode arrays are described, which are designed to image modulations of the electrical potentials over a wide spatiotemporal range. In the second part, typical applications and scientific questions in neuroscience research addressed so far are reviewed. The review ends with an outlook on expected developments.
CoS Quantum Dot Nanoclusters for High‐Energy Potassium‐Ion Batteries
Authors: Gao Hong , Zhou Tengfei , Zheng Yang , Zhang Qing , Liu Yuqing , Chen Jun , Liu Huakun , Guo Zaiping 
Published: October 2017

AbstractPotassium‐ion batteries (PIBs) are a promising alternative to lithium‐ion batteries because potassium is an abundant natural resource. To date, PIBs are in the early stages of exploration and only a few anode materials have been investigated. This study reports a cobalt sulfide and graphene (CoS@G) composite as anode electrode for PIBs for the first time. The composite features interconnect quantum dots of CoS nanoclusters uniformly anchored on graphene nanosheets. The coexistence of CoS quantum dot nanoclusters and graphene nanosheets endows the composite with large surface area, highly conductive network, robust structural stability, and excellent electrochemical energy storage performance. An unprecedented capacity of 310.8 mA h g−1 at 500 mA g−1 is obtained after 100 cycles, with a rate capability better than an equivalent sodium‐ion batteries (SIBs). This work provides the evidence that PIBs can be a promising alternative to SIBs, especially at high charge–discharge rates. The development of the CoS@G anode material also provides the basis of expanding the library of suitable anode materials for PIBs.
A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation
Authors: Kim Chang‐Su , Kim Jin‐Hee , Kim Bokyoung , Park Young‐Seok , Kim Hong‐Kyun , Tran Hieu Trung , Kim Sang Hoon , Jeon Hojeong , Kim Sangjib , Sim Ji Hyun , Shin Hyun Mu , Kim Gwanghun , Baik Young Joo , Lee Kee‐Joon , Kim Hae‐Young , Yun Tae Jin , Kim Youn Sang , Kim Hang‐Rae 
Published: October 2017

AbstractLittle is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ‐2 and AZ‐4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical‐sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.
pH‐Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy
Authors: Liu Jingjing , Wang Hairong , Yi Xuan , Chao Yu , Geng Yuehao , Xu Ligeng , Yang Kai , Liu Zhuang 
Published: October 2017

AbstractAlthough various types of radiosensitizers based on nanoparticles are explored to enhance radiotherapy via different mechanisms, nanoscale radiosensitizers with full biodegradability, sensitive responsiveness to the tumor microenvironment, as well as the ability to greatly amplify radiation‐induced tumor destruction are still demanded. Herein, this study designs nanoscale coordination polymers (NCPs) based on acidic sensitive linker and high Z number element hafnium (Hf) ions. Chloro(triphenylphosphine)gold(I) (TPPGC), a chemotherapeutic drug, is successfully loaded into those NCPs after they are coated with polyethylene glycol (PEG). Owing to the acid‐triggered cleavage of the organic linker, such formed NCP‐PEG/TPPGC nanoparticles would be dissociated under reduced pH within the tumor, leading to the release of TPPGC to induce mitochondrial damage and arrest the cell cycle of tumor cells into the radiosensitive phase (G1). Meanwhile, Hf ions are able to act as radiosensitizers by absorbing X‐ray and depositing radiation energy within tumors. With efficient tumor accumulation after intravenous injection, NCP‐PEG/TPPGC offers remarkable synergistic therapeutic outcome in chemoradiotherapy without appreciable toxic side effect. This work thus presents a biodegradable nano‐radiosensitizer with in vivo tumor‐specific decomposition/drug release profiles and great efficacy in chemoradiotherapy of cancer.
Selective Dispersion of Large‐Diameter Semiconducting Carbon Nanotubes by Functionalized Conjugated Dendritic Oligothiophenes for Use in Printed Thin Film Transistors
Authors: Gao Wei , Xu Wenya , Ye Jun , Liu Tingting , Wang Junkai , Tan Hongwei , Lin Yi , Tange Masayoshi , Sun Dongfeng , Wu Liangzhuan , Okazaki Toshiya , Yang Yingjun , Zhang Zhiyong , Zhao Jianwen , Cui Zheng , Ma Chang‐Qi 
Published: October 2017

AbstractSelective dispersion of semiconducting single walled carbon nanotubes (s‐SWCNTs) by conjugated polymer wrapping is recognized as the most promising scalable method for s‐SWCNT separation. Despite a number of linear conjugated polymers being reported for use in s‐SWCNT separation, these linear polymers suffer batch‐to‐batch variation for their undefined molecular structure. Here, it is reported that conjugated dendritic oligothiophenes with multiple diketopyrrolopyrrole groups at the periphery have the capability of selectively dispersing large diameter s‐SWCNTs with high dispersion efficiency and certain chiral selectivity. Printed top‐gated thin film transistors using the dendrimer sorted s‐SWCNTs show high charge carrier mobility of up to 57 cm2 V−1 s−1 and on/off ratios of ≈106 with high reproducibility, which is ascribed to the defined and monodispersed molecular structure of dendrimers. Moreover, owing to the multiple peripheral anchoring groups of these dendritic molecules, these dendrimer‐s‐SWCNT dispersions display excellent stability. The current work proves that dendritic molecules are excellent dispersion reagents for s‐SWCNT separation.
An Ultrastable and High‐Performance Flexible Fiber‐Shaped Ni–Zn Battery based on a Ni–NiO Heterostructured Nanosheet Cathode
Authors: Zeng Yinxiang , Meng Yue , Lai Zhengzhe , Zhang Xiyue , Yu Minghao , Fang Pingping , Wu Mingmei , Tong Yexiang , Lu Xihong 
Published: October 2017

AbstractCurrently, the main bottleneck for the widespread application of Ni–Zn batteries is their poor cycling stability as a result of the irreversibility of the Ni‐based cathode and dendrite formation of the Zn anode during the charging–discharging processes. Herein, a highly rechargeable, flexible, fiber‐shaped Ni–Zn battery with impressive electrochemical performance is rationally demonstrated by employing Ni–NiO heterostructured nanosheets as the cathode. Benefiting from the improved conductivity and enhanced electroactivity of the Ni–NiO heterojunction nanosheet cathode, the as‐fabricated fiber‐shaped Ni–NiO//Zn battery displays high capacity and admirable rate capability. More importantly, this Ni–NiO//Zn battery shows unprecedented cyclic durability both in aqueous (96.6% capacity retention after 10 000 cycles) and polymer (almost no capacity attenuation after 10 000 cycles at 22.2 A g−1) electrolytes. Moreover, a peak energy density of 6.6 µWh cm−2, together with a remarkable power density of 20.2 mW cm−2, is achieved by the flexible quasi‐solid‐state fiber‐shaped Ni–NiO//Zn battery, outperforming most reported fiber‐shaped energy‐storage devices. Such a novel concept of a fiber‐shaped Ni–Zn battery with impressive stability will greatly enrich the flexible energy‐storage technologies for future portable/wearable electronic applications.
In Situ GIWAXS Analysis of Solvent and Additive Effects on PTB7 Thin Film Microstructure Evolution during Spin Coating
Authors: Manley Eric F. , Strzalka Joseph , Fauvell Thomas J. , Jackson Nicholas E. , Leonardi Matthew J. , Eastham Nicholas D. , Marks Tobin J. , Chen Lin X. 
Published: October 2017

AbstractThe influence of solvent and processing additives on the pathways and rates of crystalline morphology formation for spin‐coated semiconducting PTB7 (poly[[4,8‐bis[(2‐ethylhexyl)oxy]benzo[1,2‐b:4,5‐b′]dithiophene‐2,6‐diyl][3‐fluoro‐2‐[(2‐ethylhexyl)‐carbonyl]‐thieno[3,4‐b]thiophenediyl]]) thin films is investigated by in situ grazing incidence wide‐angle X‐ray scattering (GIWAXS) and optical reflectance, to better understand polymer solar cell (PSC) optimization approaches. In situ characterization of PTB7 film formation from chloroform (CF), chlorobenzene (CB), and 1,2‐dichlorobenzene (DCB) solutions, as well as CB solutions with 1% and 3% v/v of the processing additives 1‐chloronapthalene (CN), diphenylether (DPE), and 1,8‐diiodooctane (DIO), reveals multiple crystallization pathways with: (i) single‐solvent systems exhibiting rapid (<3 s) crystallization after a solvent boiling point‐dependent film thinning transition, (ii) solvent + additive systems exhibiting different crystallization pathways and crystallite formation times from minutes (CN, DPE) to 1.5 h (DIO). Identifying crystalline intermediates has implications for bulk‐heterojunction PSC morphology optimization via optimized spin‐casting processes.
Broadband Surface‐Enhanced Photoluminescence Based on Gold Nanocubic Self‐Assembly
Authors: Ding Yufeng , You Yunchang , Sang Yungang , Wang Yanrong , Zhao Man , Liang Chao , Lu Chenguang , Liu Dahe , Zhou Jing , Tang Zhiyong , Shi Jinwei 
Published: October 2017

AbstractLow‐cost materials with large‐area, broadband, and strong photoluminescence are of great interest in many fields. Plasmonic enhancement structures, based on nanoparticle self‐assembly, are identified as promising candidates for achieving these requirements. This study fabricates Au nanocube assemblies and demonstrates photoluminescence enhancement of quantum dots (QDs) deposited on their surfaces. The enhancement factor of this large‐area ensemble is ≈3.5 with the use of a 532 nm pulse laser to excite red‐emissive QDs. Furthermore, the broadband response of this assembly is studied and enhanced broadband white‐light emission is found. Finally, a new optical information storage method based on this photoluminescence enhancement is demonstrated. The results have significance for applications, such as energy‐saving lighting and displays, solar energy harvesting, optical data storage, and anticounterfeiting measures.
Improved Optics in Monolithic Perovskite/Silicon Tandem Solar Cells with a Nanocrystalline Silicon Recombination Junction
Authors: Sahli Florent , Kamino Brett A. , Werner Jérémie , Bräuninger Matthias , Paviet‐Salomon Bertrand , Barraud Loris , Monnard Raphaël , Seif Johannes Peter , Tomasi Andrea , Jeangros Quentin , Hessler‐Wyser Aïcha , De Wolf Stefaan , Despeisse Matthieu , Nicolay Sylvain , Niesen Bjoern , Ballif Christophe 
Published: October 2017

AbstractPerovskite/silicon tandem solar cells are increasingly recognized as promi­sing candidates for next‐generation photovoltaics with performance beyond the single‐junction limit at potentially low production costs. Current designs for monolithic tandems rely on transparent conductive oxides as an intermediate recombination layer, which lead to optical losses and reduced shunt resistance. An improved recombination junction based on nanocrystalline silicon layers to mitigate these losses is demonstrated. When employed in monolithic perovskite/silicon heterojunction tandem cells with a planar front side, this junction is found to increase the bottom cell photocurrent by more than 1 mA cm−2. In combination with a cesium‐based perovskite top cell, this leads to tandem cell power‐conversion efficiencies of up to 22.7% obtained from J–V measurements and steady‐state efficiencies of up to 22.0% during maximum power point tracking. Thanks to its low lateral conductivity, the nanocrystalline silicon recombination junction enables upscaling of monolithic perovskite/silicon heterojunction tandem cells, resulting in a 12.96 cm2 monolithic tandem cell with a steady‐state efficiency of 18%.
High Energy Density Sodium‐Ion Battery with Industrially Feasible and Air‐Stable O3‐Type Layered Oxide Cathode
Authors: Deng Jianqiu , Luo Wen‐Bin , Lu Xiao , Yao Qingrong , Wang Zhongmin , Liu Hua‐Kun , Zhou Huaiying , Dou Shi‐Xue 
Published: October 2017

AbstractExtensive effort is being made into cathode materials for sodium‐ion battery to address several fatal issues, which restrict their future application in practical sodium‐ion full cell system, such as their unsatisfactory initial Coulombic efficiency, inherent deficiency of cyclable sodium content, and poor industrial feasibility. A novel air‐stable O3‐type Na[Li0.05Mn0.50Ni0.30Cu0.10Mg0.05]O2 is synthesized by a coprecipitation method suitable for mass production followed by high‐temperature annealing. The microscale secondary particle, consisting of numerous primary nanocrystals, can efficiently facilitate sodium‐ion transport due to the short diffusion distance, and this cathode material also has inherent advantages for practical application because of its superior physical properties. It exhibits a reversible capacity of 172 mA h g−1 at 0.1 C and remarkable capacity retention of 70.4% after 1000 cycles at 20 C. More importantly, it offers good compatibility with pristine hard carbon as anode in the sodium‐ion full cell system, delivering a high energy density of up to 215 W h kg−1 at 0.1 C and good rate performance. Owing to the high industrial feasibility of the synthesis process, good compatibility with pristine hard carbon anode, and excellent electrochemical performance, it can be considered as a promising active material to promote progress toward sodium‐ion battery commercialization.
Dental microwear textural analysis as an analytical tool to depict individual traits and reconstruct the diet of a primate
Authors: Percher Alice M. , Merceron Gildas , Nsi Akoue Gontran , Galbany Jordi , Romero Alejandro , Charpentier Marie JE 
Published: October 2017

AbstractObjectivesDental microwear is a promising tool to reconstruct animals' diet because it reflects the interplay between the enamel surface and the food items recently consumed. This study examines the sources of inter‐individual variations in dietary habits in a free‐ranging population of mandrills (Mandrillus sphinx) using a combination of feeding monitoring and in vivo dental microwear textural analysis (DMTA).MethodsWe investigated the impact of seasonality and individual traits on four DMTA parameters. In parallel, we further studied the influence of the physical properties of the food items consumed on these four parameters, using three proxies (mechanical properties, estimates of phytolith and external grit contents).ResultsWe found that seasonality, age, and sex all impact DMTA parameters but those results differ depending on the facet analyzed (crushing vs. shearing facets). Three DMTA parameters (anisotropy, complexity, and heterogeneity of complexity) appear sensitive to seasonal variations and anisotropy also differs between the sexes while textural fill volume tends to vary with age. Moreover, the physical properties of the food items consumed vary seasonally and also differ depending on individual sex and age.ConclusionConsidering the interplay between the tested variables and both dental microwear and diet, we reaffirm that food physical properties play a major role in microwear variations. These results suggest that DMTA parameters may provide valuable hints for paleoecological reconstruction using fragmentary fossil dental remains.
In Situ Spatial Complementation of Aptamer‐Mediated Recognition Enables Live‐Cell Imaging of Native RNA Transcripts in Real Time
Authors: Wang Zejun , Luo Yao , Xie Xiaodong , Hu Xingjie , Song Haiyun , Zhao Yun , Shi Jiye , Wang Lihua , Glinsky Gennadi , Chen Nan , Lal Ratnesh , Fan Chunhai 
Published: October 2017

AbstractDirect cellular imaging of the localization and dynamics of biomolecules helps to understand their function and reveals novel mechanisms at the single‐cell resolution. In contrast to routine fluorescent‐protein‐based protein imaging, technology for RNA imaging remains less well explored because of the lack of enabling technology. Herein, we report the development of an aptamer‐initiated fluorescence complementation (AiFC) method for RNA imaging by engineering a green fluorescence protein (GFP)‐mimicking turn‐on RNA aptamer, Broccoli, into two split fragments that could tandemly bind to target mRNA. When genetically encoded in cells, endogenous mRNA molecules recruited Split‐Broccoli and brought the two fragments into spatial proximity, which formed a fluorophore‐binding site in situ and turned on fluorescence. Significantly, we demonstrated the use of AiFC for high‐contrast and real‐time imaging of endogenous RNA molecules in living mammalian cells. We envision wide application and practical utility of this enabling technology to in vivo single‐cell visualization and mechanistic analysis of macromolecular interactions.
“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane
Authors: Bain Ryan M. , Sathyamoorthi Shyam , Zare Richard N. 
Published: October 2017

AbstractSharpless and co‐workers previously studied the [2σ+2σ+2π] cycloaddition of diethyl azodicarboxylate (DEAD) and quadricyclane and reported that the addition of water to the neat reagents caused an acceleration in the reaction rate, giving birth to what has been called “on‐water” chemistry. We have examined the same reaction in aqueous microdroplets (ca. 5 μm diameter) and find that the cycloaddition reaction is accelerated even further (by a factor of 102) compared to that of the “on‐water” reaction reported previously. The trends of acceleration in solvents other than water demonstrated by Sharpless and colleagues were replicated in the corresponding microdroplet experiments. We also find that DEAD reacts with itself to form a variety of hydrazine carboxylates and intercept intermediates of this reaction in microdroplets to validate a mechanism proposed herein. We suggest that “on‐droplet” chemistry, similar to “on‐water” chemistry, may be a general process of synthetic interest.
Hydrogen Peroxide Insular Dodecameric and Pentameric Clusters in Peroxosolvate Structures
Authors: Grishanov Dmitry A. , Navasardyan Mger A. , Medvedev Alexander G. , Lev Ovadia , Prikhodchenko Petr V. , Churakov Andrei V. 
Published: October 2017

AbstractPeroxosolvates of 2‐aminonicotinic acid (I) and lidocaine N‐oxide (II) including the largest insular hydrogen peroxide clusters were isolated and their crystal structures were determined by single‐crystal X‐ray diffraction. An unprecedented dodecameric hydrogen peroxide insular cluster was found in I. An unusual cross‐like pentameric cluster was observed in the structure of II. The topology of the (H2O2)12 assembly was never observed for small‐molecule clusters. In I and II new double and triple cross‐orientational disorders of H2O2 were found. Cluster II is the first example of a peroxosolvate crystal structure containing H2O2 molecules with a homoleptic hydrogen peroxide environment. In II, a hydrogen bond between an H2O2 molecule and a peptide group ‐CONH⋅⋅⋅O2H2 was observed for the first time.
Combining Charge‐Transfer Pathways to Achieve Unique Thermally Activated Delayed Fluorescence Emitters for High‐Performance Solution‐Processed, Non‐doped Blue OLEDs
Authors: Chen Xu‐Lin , Jia Ji‐Hui , Yu Rongmin , Liao Jian‐Zhen , Yang Ming‐Xue , Lu Can‐Zhong 
Published: October 2017

AbstractTwo efficient blue thermally activated delayed fluorescence compounds, B‐oCz and B‐oTC, composed of ortho‐donor (D)–acceptor (A) arrangement were designed and synthesized. The significant intramolecular D–A interactions induce a combined charge transfer pathway and thus achieve small ΔEST and high efficiencies. The concentration quenching can be effectively inhibited in films of these compounds. The blue non‐doped organic light emitting diodes (OLEDs) based on B‐oTC prepared from solution processes shows record‐high external quantum efficiency (EQE) of 19.1 %.