bluuebunny/crossref_metadata_2025_split huggingface dataset:
From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns
Authors: Salentin Sebastian , Adasme Melissa F. , Heinrich Jörg C. , Haupt V. Joachim , Daminelli Simone , Zhang Yixin , Schroeder Michael 
Published: September 2017

AbstractDrug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent. While most repositioning efforts emerge through serendipity, we have devised a computational approach, which exploits interaction patterns shared between compounds. As a test case, we took the anti-viral drug brivudine (BVDU), which also has anti-cancer activity, and defined ten interaction patterns using our tool PLIP. These patterns characterise BVDU’s interaction with its target s. Using PLIP we performed an in silico screen of all structural data currently available and identified the FDA approved malaria drug amodiaquine as a promising repositioning candidate. We validated our prediction by showing that amodiaquine suppresses chemoresistance in a multiple myeloma cancer cell line by inhibiting the chaperone function of the cancer target Hsp27. This work proves that PLIP interaction patterns are viable tools for computational repositioning and can provide search query information from a given drug and its target to identify structurally unrelated candidates, including drugs approved by the FDA, with a known safety and pharmacology profile. This approach has the potential to reduce costs and risks in drug development by predicting novel indications for known drugs and drug candidates.
Infizierte Plattenosteosynthese
Authors: Gerlach Ulf-Joachim 
Published: September 2017

ZusammenfassungDie Infektion nach Plattenosteosynthese stellt eine schwerwiegende Komplikation dar und muss konsequent behandelt werden. Das Infektrisiko steigt bei offenen Frakturen und dem Vorliegen systemischer Begleiterkrankungen. Bei der Frühinfektion ist die klinische Diagnose entscheidend. Die operative Versorgung ist zeitnah durchzuführen. Die Plattenosteosynthese kann bei stabiler Situation erhalten werden unter Wechsel der Platte nach erfolgtem radikalem Débridement, Lavage und Einlage lokaler Antibiotikumträger. Bei instabiler Osteosynthese ist auf eine Fixateur-externe-Stabilisierung umzusteigen. Die Therapie der chronischen Infektion nach Plattenosteosynthese ist aufwendiger, häufig mehrzeitig und multidisziplinär. Im 1. operativen Schritt ist das einliegende Osteosynthesematerial zu entfernen. Eine radikale Sequestrektomie und ein Débridement der infizierten Weichteile ist durchzuführen, die Stabilisierung erfolgt über einen externen Fixateur. Möglicherweise vorliegende Hautweichteildefekte sind zeitnah und stabil zu verschließen. Nach dauerhafter Infektberuhigung erfolgt der Knochendefektaufbau, entweder durch Spongiosaplastik oder bei größeren Defekten über einen Segmenttransport.
Infekt bei intramedullärem Implantat
Authors: Militz Matthias 
Published: September 2017

ZusammenfassungInfektionen an langen Röhrenknochen und intramedullärem Implantat stellen eine besondere Herausforderung in der chirurgischen Behandlung dar. Der Vorteil der intramedullären Platzierung des Osteosynthesematerials schlägt im Falle einer Infektion in das Gegenteil um, da die Infektion in aller Regel den gesamten Markraum betrifft, in dem das Implantat platziert ist. Bei der operativen Therapie steht die konsequente Sequestrektomie mit Implantatentfernung im Vordergrund. Gerade bei Trümmerzonen im Frakturbereich kann die Sequestrektomie oft nur über einen offenen Zugang erreicht werden, die u. U. auch eine Segmentresektion beinhaltet. Für die Knochen- und Weichteilrekonstruktion ist nach der Infekteradikation die Optimierung der Perfusion zu prüfen. Die Stabilisierung im Sanierungsintervall mit einem Fixateur beeinträchtigt den Markraumzugang und sollte der definitiven Rekonstruktion vorbehalten bleiben. Temporär kann die Immobilisierung im Cast vorgenommen werden, am Femur hat sich die Behandlung mit einem Wechselnagel in unserem Therapiekonzept bewährt. Begleitend zu den chirurgischen Maßnahmen sind die interdisziplinäre Betreuung und die Antibiotikabehandlung entsprechend dem ABS-Prinzip umzusetzen. Infektionen an langen Röhrenknochen und intramedullärem Implantat stellen eine besondere Herausforderung in der chirurgischen Behandlung dar.
Nicht-konvulsiver Status epilepticus des Erwachsenen: Typen, Pathophysiologie, Epidemiologie, Ursachen und Diagnose
Authors: Rüegg Stephan 
Published: September 2017

ZusammenfassungDer nicht-konvulsive Status epilepticus (NKSE) ist gekennzeichnet durch andauernde elektroklinische epileptische Aktivität oder durch eine Abfolge von epileptischen Anfällen, zwischen denen der Patient nicht zum Vorzustand zurückkehrt, und die ohne eindeutige tonische-klonische Entäußerungen einhergehen. Diese „stille“ Manifestation andauernder klinisch-neurologischer Symptome wie Aphasie, Verwirrung, etc. erschwert das Erkennen eines NKSE; oft ist der wichtigste Diagnoseschritt, überhaupt daran zu denken, dass die vorliegende Klinik auf einem NKSE beruhen könnte. Sicher nachgewiesen und bestätigt werden kann der NKSE nur durch eine unmittelbare EEG-Ableitung. In epidemiologischen Studien scheint der konvulsive Status epilepticus (KSE) häufiger (60 : 40 %) vorzukommen, doch dies ist fraglich, werden doch viele NKSE aufgrund der unspektakulären Manifestation verpasst. Pathophysiologisch spielen sich auf neuronaler Ebene dieselben Phänomene wie beim KSE ab, einfach nur nicht in den primären Motoneuronen. Die permanente Hyperexzitabilität kann die vom NKSE betroffenen Neuronen genauso schädigen. Hingegen fehlen die unmittelbar vital bedrohlichen sekundären pathophysiologischen Folgen des KSE (Lactat-Azidose, respiratorische Erschöpfung, Rhabdomyolyse, etc.) beim NKSE weitgehend. Doch auch dort können autonome Phänomene (Arrhythmien [Kammertachykardie oder Asystolie] und Atmungsprobleme) den Patienten akut lebensgefährlich gefährden. Die Ursachen für einen NKSE sind vielfältig und umfassen bei Patienten mit einer bekannten Epilepsie v. a. Medikationsprobleme (mangelnde Adhärenz, Interaktionen bei Zugabe anderer Medikamente); bei ihnen sowie denjenigen Betroffenen ohne bekannte Epilepsie kommen metabolische, toxische, strukturelle (Tumore, Blutungen, Ischämien), infektiöse, entzündliche und autoimmune Ursachen in Frage. Entsprechend breit sollte die Ursache für einen NKSE abgeklärt werden, da besonders bei den akuten symptomatischen Formen die Behandlung der Ursache mindestens so wichtig ist wie die anfallsbeendende Behandlung des NKSE.
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers
Authors: Cohen Joshua D. , Javed Ammar A. , Thoburn Christopher , Wong Fay , Tie Jeanne , Gibbs Peter , Schmidt C. Max , Yip-Schneider Michele T. , Allen Peter J. , Schattner Mark , Brand Randall E. , Singhi Aatur D. , Petersen Gloria M. , Hong Seung-Mo , Kim Song Cheol , Falconi Massimo , Doglioni Claudio , Weiss Matthew J. , Ahuja Nita , He Jin , Makary Martin A. , Maitra Anirban , Hanash Samir M. , Dal Molin Marco , Wang Yuxuan , Li Lu , Ptak Janine , Dobbyn Lisa , Schaefer Joy , Silliman Natalie , Popoli Maria , Goggins Michael G. , Hruban Ralph H. , Wolfgang Christopher L. , Klein Alison P. , Tomasetti Cristian , Papadopoulos Nickolas , Kinzler Kenneth W. , Vogelstein Bert , Lennon Anne Marie 
Published: September 2017

SignificanceFew patients with pancreatic cancer survive longer than 5 y, in part because most patients are identified only after their disease has progressed to an advanced stage. In this study, we show how combining mutations in circulating tumor DNA (ctDNA) with protein markers can result in a screening test with improved sensitivity while retaining specificity. The combination of the ctDNA and protein markers was superior to any single marker. Moreover, the combination detected nearly two-thirds of pancreatic cancers that had no evidence of distant metastasis at the time of surgical resection. The strategy may represent an approach to detect cancers of many types at an earlier stage.
Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
Authors: Antonios Joseph P. , Soto Horacio , Everson Richard G. , Moughon Diana L. , Wang Anthony C. , Orpilla Joey , Radu Caius , Ellingson Benjamin M. , Lee Jason T. , Cloughesy Timothy , Phelps Michael E. , Czernin Johannes , Liau Linda M. , Prins Robert M. 
Published: September 2017

Significance
The inability to accurately monitor glioblastoma tumor progression vs. pseudoprogression has severely limited clinical treatment decisions, especially in the setting of immunotherapy. We have identified a novel noninvasive imaging combination that could distinguish intracranial immune responses from tumor progression in mice bearing orthotopic gliomas and in patients with glioblastomas. We combined the use of advanced MRI with PET imaging of deoxycytidine kinase, an enzyme overexpressed in immune cells. This combination resulted in superior differentiation between immune responses and tumors within the brain, and identified peripheral lymph nodes in which immune responses occurred after immunotherapy combinations. This combined imaging approach may provide a useful method to clinically monitor patients with glioblastomas treated with immune-based therapies, and to distinguish tumor progression from pseudoprogression.
Receptor-mediated chitin perception in legume roots is functionally separable from Nod factor perception
Authors: Bozsoki Zoltan , Cheng Jeryl , Feng Feng , Gysel Kira , Vinther Maria , Andersen Kasper R. , Oldroyd Giles , Blaise Mickael , Radutoiu Simona , Stougaard Jens 
Published: September 2017

Significance
Like 80–90% of land plants, legumes form endosymbioses with arbuscular mycorrhizal fungi, host endophytes, support a rhizosphere community, and are attacked by pathogens. The ability of root cells to distinguish between these soil microbes and the mixture of chitinaceous compounds they display as signal molecules is important for an appropriate plant response. We show that legumes possess very similar receptors enabling root cells to separate perception of chitin, which triggers responses to pathogens, from perception of lipochitin oligosaccharides (Nod factors), which trigger endosymbiosis with rhizobial bacteria. The chitin receptors bind chitin in biochemical assays, and inactivation of the corresponding genes impairs defense responses toward pathogens. Together this establishes a long-sought foundation for dissecting plants’ response mechanisms toward different soil microbes.
Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation
Authors: Sleep Eduard , Cosgrove Benjamin D. , McClendon Mark T. , Preslar Adam T. , Chen Charlotte H. , Sangji M. Hussain , Pérez Charles M. Rubert , Haynes Russell D. , Meade Thomas J. , Blau Helen M. , Stupp Samuel I. 
Published: September 2017

Significance
Most research aiming to achieve muscle regeneration focuses on the biology of “muscle stem cells,” but delivery methods that enhance transplantation efficiency of these cells are at early stages. We report on a liquid crystalline scaffold that encapsulates the cells and gels upon injection in vivo without requiring an external stimulus. As a unique structural feature, the scaffold contains nanofibers that align preferentially with surrounding natural muscle fibers. The biomimetic scaffold can have a stiffness that matches that of muscle, has great ability to retain growth factors, and has a biodegradation rate that is compatible with regeneration time scales. Most importantly, the scaffold enhances engraftment efficiency of the cells in injured muscle, and without injury when combined with growth factors.
Dissection of theDrosophilaneuropeptide F circuit using a high-throughput two-choice assay
Authors: Shao Lisha , Saver Mathias , Chung Phuong , Ren Qingzhong , Lee Tzumin , Kent Clement F. , Heberlein Ulrike 
Published: September 2017

SignificanceThe perception and processing of rewarding events are essential for organismal survival. InDrosophila, several groups of neurons have been shown to mediate reward perception or processing. However, a complete description of the reward circuit is missing. Here, we describe a simple two-choice, high-throughput assay suitable for performing large neuronal activation screens for neural circuits involved in reward perception/processing. We characterized this assay using activation of neuropeptide F (NPF) neurons, a known rewarding experience for flies. Furthermore, using genetic intersectional strategies, we subdivided the NPF neurons into different classes and showed that the activation of a subset of small NPF neurons located in the dorsomedial brain is sufficient to trigger preference.
Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform
Authors: Wan Hao , Merriman Chengfeng , Atkinson Mark A. , Wasserfall Clive H. , Mcgrail Kieran M. , Liang Yongye , Fu Dax , Dai Hongjie 
Published: September 2017

Significance
Autoantibody directed against the pancreatic zinc transport 8 (ZnT8) is used as a major biomarker for identifying and staging presymptomatic type 1 diabetes (T1D). Owing to difficulties in maintaining the tertiary structure outside a membrane environment, full-length ZnT8 has been somewhat limited for ZnT8A detection. In this work, we realized efficient ZnT8A detection using a proteoliposome-based full-length ZnT8 (PLR-ZnT8) self-antigen immobilized on a plasmonic gold platform (pGOLD). Proteoliposomes immobilized on pGOLD improved the proper folding and structural stability of full-length ZnT8 and thus enabled autoreactive sites accessible to ZnT8A, leading to the superior microarray-based assay performance of ZnT8A detection. This proteoliposome-based strategy opens up a new way to develop effective self-antigens to capture autoantibodies for disease diagnosis.
Mesoscale martensitic transformation in single crystals of topological defects
Authors: Li Xiao , Martínez-González José A. , Hernández-Ortiz Juan P. , Ramírez-Hernández Abelardo , Zhou Ye , Sadati Monirosadat , Zhang Rui , Nealey Paul F. , de Pablo Juan J. 
Published: September 2017

Significance
The processes that mediate crystal nucleation and growth, and the transformation between crystal structures having different lattice symmetries, are of fundamental importance to a wide range of scientific disciplines. Here, we use single crystals of liquid-crystal blue phases with a controlled orientation to study the liquid analog of a crystal–crystal transformation. In contrast to traditional atomic crystals, the transitions that arise in blue phases take place over submicron length scales. They do, however, occur in a diffusionless manner, with characteristics that are reminiscent of traditional martensitic transformations in atomic crystals.
Self-healing catalysis in water
Authors: Costentin Cyrille , Nocera Daniel G. 
Published: September 2017

Significance
Water provides an attractive medium for storing solar energy via water splitting. Charge-separated states generated by solar capture may be transferred to catalysts that split water to hydrogen and oxygen. Most water-splitting catalysts comprising earth-abundant elements are susceptible to corrosion when operated in neutral and natural water. Such corrosion may be circumvented if the catalysts are self-healing. The design of self-healing catalysts allows neutral water and natural water sources to be used for water splitting, greatly simplifying the implementation of using water as a distributed energy storage medium for solar energy.
Heat flow, seismic cut-off depth and thermal modeling of the Fennoscandian Shield
Authors: Veikkolainen Toni , Kukkonen Ilmo T , Tiira Timo 
Published: September 2017

SummaryBeing far from plate boundaries but covered with seismograph networks, the Fennoscandian Shield features an ideal test laboratory for studies of intraplate seismicity. For this purpose, this study applies 4190 earthquake events from years 2000–2015 with magnitudes ranging from 0.10 to 5.22 in Finnish and Swedish national catalogues. In addition, 223 heat flow determinations from both countries and their immediate vicinity were used to analyse the potential correlation of earthquake focal depths and the spatially interpolated heat flow field. Separate subset analyses were performed for five areas of notable seismic activity: the southern Gulf of Bothnia coast of Sweden (area 1), the northern Gulf of Bothnia coast of Sweden (area 2), the Swedish Norrbotten and western Finnish Lapland (area 3), the Kuusamo region of Finland (area 4) and the southernmost Sweden (area 5). In total, our subsets incorporated 3619 earthquake events. No obvious relation of heat flow and focal depth exists, implying that variations of heat flow are primarily caused by shallow lying heat producing units instead of deeper sources. This allows for construction of generic geotherms for the range of representative palaeoclimatically corrected (steady-state) surface heat flow values (40–60 mW m−2). The 1-D geotherms constructed for a three-layer crust and lithospheric upper mantle are based on mantle heat flow constrained with the aid of mantle xenolith thermobarometry (9–15 mW m−2), upper crustal heat production values (3.3–1.1 μWm−3) and the brittle-ductile transition temperature (350 °C) assigned to the cut-off depth of seismicity (28 ± 4 km). For the middle and lower crust heat production values of 0.6 and 0.2 μWm−3 were assigned, respectively. The models suggest a Moho temperature range of 460–500 °C.
Oxytocin and Plasticity of Social Behavior
Authors: Hammock Elizabeth A.D. 
Published: September 2017

Abstract
Oxytocin plays well-known roles in modulating social behavior in mammals. Oxytocin function depends on the brain circuitry it modulates, which is determined by the cell-type specific expression of the oxytocin receptor and the network integration of those cells. This review describes emerging evidence for the neural network mechanisms of oxytocin in behavioral plasticity in adults and development. A role for oxytocin in modulating excitatory/inhibitory balance and improving signal:noise processing is an emerging mechanism of function. This emerging literature calls for developmental studies of oxytocin modulation of signal:noise processing in socially naïve circuits. In this review, current oxytocin research findings are placed within the coordinate system of the Uncanny Valley Hypothesis as a model to better understand the role of oxytocin in experience-dependent development and adulthood, to translate research results among diverse mammalian species, and to generate testable predictions for future research.
Frantz Fanon, The Wretched of the Earth
Authors: McBride Keally 
Published: September 2017

Abstract
Frantz Fanon’s The Wretched of the Earth is a handbook for developing anticolonial revolutionary consciousness. It offers an analysis of the structures created by colonialism that need to be overcome, and predicts the political distortions that might occur in postcolonial regimes. All three of these themes involve a discussion of structural and interpersonal violence as a central force in politics. Fanon’s political theory traces the interconnected nature of economic, institutional, and psychological racialized violence that undergirds modern global relations. This chapter explores Fanon’s historical analysis of decolonization, emphasizing the difficulty of achieving individual freedom and the pitfalls of collective and violent struggle. Furthermore, Fanon’s volume predicts the growth of new forms of imperialism, and the continued economic exploitation of former colonies.
Comparison of Vaginal Hysterectomy Techniques and Interventions for Benign Indications: A Systematic Review
Authors: Jeppson Peter C. , Balgobin Sunil , Rahn David D. , Matteson Kristen A. , Dieter Alexis A. , Ellington David R. , Aschkenazi Sarit O. , Grimes Cara , Mamik Mamta M. , Balk Ethan M. , Murphy Miles 
Published: September 2017

(Abstracted from Obstet Gynecol 2017;129:877–886)
Barriers to performing a vaginal hysterectomy (VH) include potential complications, technical difficulties, lack of experience, and low-volume caseload. Increased knowledge is needed about factors associated with success and failure of a vaginal approach.
Use of Combined Hormonal Contraceptives Among Women With Migraines and Risk of Ischemic Stroke
Authors: Champaloux Steven W. , Tepper Naomi K. , Monsour Michael , Curtis Kathryn M. , Whiteman Maura K. , Marchbanks Polly A. , Jamieson Denise J. 
Published: September 2017

(Abstracted from Am J Obstet Gynecol 2017;216:489.e1–489.e7)
Migraine headaches occur commonly in women; more than 40% will have a migraine during their lifetime. Women of reproductive age who experience migraine, especially those with aura are at increased risk of ischemic stroke.
Racial and Social Predictors of Longitudinal Cervical Measures: The Cervical Ultrasound Study
Authors: Harville E. W. , Miller K. S. , Knoepp L. R. 
Published: September 2017

(Abstracted from J Perinatol 2017;37:335–339)
Shorter cervical length is associated with preterm birth (PTB), and previous studies have found that women of African origin have shorter cervical length than do white women and are more prone to cervical insufficiency. Cervical shape (a “V”- and “U”-shaped funnel) and changes to cervical shape and length are also associated with PTB.
Tubal Ligation and Incidence of 26 Site-Specific Cancers in the Million Women Study
Authors: Gaitskell Kezia , Coffey Kate , Green Jane , Pirie Kirstin , Reeves Gillian K. , Ahmed Ahmed A. , Barnes Isobel , Beral Valerie 
Published: September 2017

(Abstracted from Br J Cancer 2016;114:1033–1037)
The risk of ovarian cancer is reduced in women who undergo tubal ligation. Although it has been suggested that tubal ligation is also associated with reduced risk of breast, endometrial, and cervical cancers, there is no clear evidence for these tumors.
A Novel, Disease-Specific Self-Report Instrument to Measure Body Image Concerns in Patients With Head and Neck Skin Cancer
Authors: Beal Brandon T. , White Emily K. , Behera Anit K. , McGuinness Ashley E. , Zavell Amy E. , Blangger Holly , Armbrecht Eric S. , Maher Ian A. 
Published: September 2017

BACKGROUND
Skin cancer commonly occurs on areas that are salient to body image perception (i.e., head and neck). Patients with head and neck skin cancer (HNSC) may experience negative body image perceptions related to their disease, which is concerning, given the numerous negative sequelae of poor body image. However, there are no existing disease-specific measures of body image concerns in HNSC.

OBJECTIVE
To develop and examine the psychometric properties of a brief self-report, disease-specific measure of body image concerns in patients with HNSC—the Body Image Questionnaire (BIQ).

MATERIALS AND METHODS
Patients with HNSC completed the BIQ before (n = 239) and 6 months after (n = 80) treatment with Mohs micrographic surgery. Analyses examined the internal consistency, convergent validity, and factor structure of the BIQ.

RESULTS
Internal consistency reliability was acceptable, and the measure demonstrated convergent validity with well-being. Four dimensions underlie the BIQ: appearance satisfaction, appearance avoidance, head/neck/skin-specific dissatisfaction, and perceived change.

CONCLUSION
The BIQ is a valid and internally reliable disease-specific instrument that measures body image concerns in patients with HNSC.