bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of constitutional mismatch repair deficiency‐associated non‐Hodgkin lymphomas in a global cohort
Authors: Rigaud Charlotte , Forster Victoria J. , Al‐Tarrah Hiba , Attarbaschi Andishe , Bianchi Vanessa , Burke Amos , Burkhardt Birgit , Colas Chrystelle , Devalck Christine , Edwards Melissa , Elitzur Sarah , Garthe Anne‐Kathrin , Goldberg Yael , Guerrini‐Rousseau Léa , Horpaopan Sukanya , Januszkiewicz‐Lewandowska Danuta , Kabíčková Edita , Kratz Christian P. , Loeffen Jan , Pérez‐Alonso Vanessa , Pineda Marta , Minard‐Colin Véronique , Rueda Daniel , Ruiz‐Ponte Clara , Trinquand Amelie , Uyttebroeck Anne , Wimmer Katharina , Auperin Anne , Tabori Uri , Brugieres Laurence 
Published: September 2024

AbstractBackgroundConstitutional mismatch repair deficiency syndrome (CMMRD) is a rare childhood cancer predisposition syndrome associated with a broad spectrum of malignancies, including non‐Hodgkin lymphomas (NHL). Most patients die due to cancer before the age of 20 years. Limited data exist on CMMRD‐associated lymphomas and their outcome.MethodsWe conducted a retrospective study including all CMMRD‐associated NHL patients registered before 2020 in the European and North American databases or reported by members of the European Intergroup for Childhood Non‐Hodgkin Lymphoma (EICNHL). Events considered to define event‐free survival included relapse/progression, second malignancy (SML), or death, whichever occurred first.FindingsThe analysis included 74 patients, with 20 having multiple metachronous NHL. The median age at diagnosis was 9.4 years. Previous malignancies were reported in 36% of the patients, café au lait spots in 96%, and consanguinity in 54%. The initial lymphoma subtypes were 53 T‐cell lymphoblastic lymphomas (T‐LBL), four B‐lymphoblastic lymphomas, and 17 mature B‐cell non‐Hodgkin lymphoma (B‐NHL). All patients were treated with curative intent, with current chemotherapy regimens adapted to their subtype. The median follow‐up was 8.7 years. After the first lymphoma, the 5‐year event‐free and overall survival rates were, respectively, 23.5% [95% confidence interval (CI): 14.9–35.1] and 61.5% [95% CI: 49.6–72.1]. The 5‐year cumulative risk of progression/relapse, SML or death as a first event was 20.8%, 52.9%, and 2.7%.InterpretationStandard treatments for sporadic NHL are effective in most CMMRD‐associated NHL cases, but multiple malignancies, including lymphomas, impair prognosis. Future strategies should evaluate the potential of less genotoxic therapies, including immunotherapy, in preventing SMLs while maintaining effective control of NHL.
The TeLeo Program: Tele‐education in pediatric oncology as a tool to support training programs in Latin America
Authors: Sampor Claudia , Alonso Rocio , Durañona Mariana , Gorostegui Maite , Antillón‐Klussmann Federico , Lopes Luiz Fernando , Cappellano Andrea M. , Gonzalez‐Ramella Oscar , Lobos Pablo , Palma Julia , Grynszpancholc Edith , Vasquez Liliana , Morales La Madrid Andrés , Moreira Daniel C. , Cruz Ofelia , Chantada Guillermo 
Published: September 2024

AbstractThe TeLeo Program offers a free‐access 2‐year online learning program to support fellowship programs in pediatric oncology, enhance networking opportunities, and facilitate the exchange of context‐specific, educational content within the pediatric oncology community in training in Latin America. In its first edition beginning in 2021, 185 fellows from 40 centers in 12 Latin American countries were enrolled. Additional courses for other healthcare professionals related to oncology in the region were produced to further support the program. A digital platform was created to allow users to easily access learning activities after registration, with 7075 professionals currently registered.
Re‐Exposure to Culprit Medication Following Adverse Drug Event Diagnosis in Canadian Emergency Department Patients: A Cohort Study
Authors: Wickham Maeve E. , McGrail Kimberlyn M. , Law Michael R. , Cragg Amber , Hohl Corinne M. 
Published: September 2024

ABSTRACTPurposeThe magnitude of repeat exposures to culprit medications after hospital discharge is not well studied. We combined prospective cohort data with administrative health data to understand the frequency of repeat exposures to culprit medications after discharge and the risk factors for their occurrence.MethodsThis was a retrospective analysis of three prospective cohorts of patients who presented to the hospital with an adverse drug event in British Columbia, from 2008 to 2015 (n = 849). We linked prospectively identified adverse drug events to administrative data to examine patterns of redispensing of culprit medications. We used Cox regression to assess risk factors for re‐exposure, and conducted subgroup analyses for essential vs. nonessential medications.ResultsAmong 849 diagnosed adverse drug events, 45.2% had subsequent culprit medication redispensing within a year of hospital discharge. The factors associated with re‐exposures included atrial fibrillation, adverse drug event type (e.g. adverse reaction), culprit medication type, and longer historical duration of medication use.ConclusionsRe‐exposures to culprit medications occurred in almost half of the adverse drug events diagnosed in emergency departments. Many of these were appropriate re‐exposures to essential medications for indications in which the risk of uncontrolled disease likely outweighed the risk of a repeat adverse event. More research is needed to understand re‐exposures to nonessential medications or medications with safer alternatives.
Teachers' emotional intelligence and job satisfaction: The mediating roles of expression of naturally felt emotion and perceived teacher‐student closeness
Authors: Li Mingwei , Cheng Ran , Liu Feifei 
Published: September 2024

AbstractGlobal concerns about low levels of teacher job satisfaction (JS) have brought the significance of understanding factors and mechanisms that contribute to this issue. In educational research, the role of emotional intelligence (EI), a critical personal resource, in relation to teachers' JS has emerged as an important topic. Utilizing the Job Demands‐Resources model, the present study proposed a chain mediation model to explore the relationship between teachers' EI and their JS. It specifically examined the roles of expression of naturally felt emotion (ENFE) and perceived teacher‐student closeness as mediators. Data from 503 Chinese primary and secondary school teachers revealed significant correlations among teachers' EI, ENFE, perceived teacher‐student closeness, and JS. Structural equation modeling indicated that EI can significantly predict JS through a sequential mediating effect involving ENFE and perceived teacher‐student closeness. The findings provide insight into the underlying mechanism between teachers' EI and JS. Implications for teacher education practices and directions for future research are discussed.
Association between autistic traits and sleep quality among Chinese junior high school students: The chain mediating roles of self‐control and mindfulness
Authors: Yi Jingchao , Xuan Bin 
Published: September 2024

AbstractTo explore the relationships between autistic traits, self‐control, mindfulness, and sleep quality, and the mechanism underlying these relationships, we recruited a sample of 972 junior high school students who completed a survey consisting of the Chinese version of the Comprehensive Autistic Trait Inventory‐short form, Self‐Control Scale, Child and Adolescent Mindfulness Measure, and Sleep Condition Indicator. The correlation analyses revealed that autistic traits were significantly negatively correlated with self‐control, mindfulness, and sleep quality. Conversely, self‐control was significantly positively correlated with mindfulness and sleep quality in junior high school students. Mediation analyses indicated that self‐control and mindfulness play a chain‐mediating role in the association between autistic traits and sleep quality among junior high school students. In conclusion, enhancing levels of self‐control and mindfulness is essential for improving sleep quality among junior high school students with high levels of autistic traits.
DNA Motifs Hydrogel Microparticles as Gold Nanocatalyst Support Material
Authors: Ishikawa Daisuke , Maruyama Koki , Hara Masahiko 
Published: September 2024

AbstractGold nanoparticles (Au NPs) are unique catalysts due to their increased coordination unsaturation via nanoparticulation. Effective functioning requires an appropriate support to maintain particle dispersion without compromising nanoscale properties. Cross‐linked hydrophilic polymer‐derived hydrogels are ideal supports, particularly for biological and biomedical reactions, due to their aqueous affinity and biocompatibility. However, applications in confined spaces, such as in vivo environments, necessitate hydrogel micronization. This study introduces microsized DNA hydrogels as support for Au catalysts. DNA motif‐composed hydrogel particles exhibit high crosslinking density and produce small Au NPs owing to short DNA strands. This system significantly enhances catalytic efficiency compared to similar‐sized Au NP gel‐supported catalysts and requires minimal gold catalyst. Modulating DNA hydrogel crosslinking density allows easy control of Au NP size and catalytic activity, further improved by increased hydrogel surface area through microparticulation. These findings demonstrate DNA nanotechnology's versatility in tailoring DNA hydrogel properties and Au NP catalytic behavior. Computer‐aided design enables precise particle property and motif arrangement manipulation, offering promising customizable catalytic systems.
A Vip3Af mutant confers high resistance to broad lepidopteran insect pests
Authors: Sun Yajie , Yang Pan , She Mingjun , Lin Chaoyang , Ye Yuxuan , Xu Chao , Shen Zhicheng 
Published: September 2024

AbstractBACKGROUNDVegetative insecticidal proteins (Vip3) from Bacillus thuringiensis (Bt) have been utilized for control of lepidopteran insect pests. The majority of known Vip3 proteins possess exceptional high toxicity against Noctuid insects such as the fall armyworm (FAW, Spodoptera frugiperda), beet armyworm (BAW, Spodoptera exigua) and cotton bollworm (CBW, Helicoverpa armigera), but generally have relatively low or even no activity against some very important pest insects, such as Asian corn borer (ACB, Ostrinia furnacalis), European corn borer (ECB, Ostrinia nubilalis), rice stem borer (RSB, Chilo suppressalis) and oriental armyworm (OAW, Mythimna separata).RESULTSHere, we report mutant Vip3Af with a single amino acid mutation, Vip3Af‐T686R, which gains significantly higher insecticidal activity against ACB, OAW and BAW, while retaining high activity against FAW, CBW and RSB. Protein proteolytic activation in vitro showed that the proteolytic activation efficiency of the mutant protein was greater than the wild‐type protein in the midgut juice of ACB, OAW and BAW. Transgenic corn expressing this mutant Vip3Af showed high levels of resistance to ACB, OAW, FAW, BAW and CBW.CONCLUSIONOur results suggest that Vip3Af may be a superior Vip3A mutant for the development of transgenic crops with resistance to a broad range of lepidopteran pest species. © 2024 Society of Chemical Industry.
A new mutation in the octopamine receptor associated with amitraz resistance in Varroa destructor
Authors: Hernández‐Rodríguez Carmen Sara , Moreno‐Martí Sara , Emilova‐Kirilova Kristina , González‐Cabrera Joel 
Published: September 2024

AbstractBACKGROUNDThe acaricide amitraz is now used intensively in many regions to control the honey bee parasite, Varroa destructor, because of the reduced efficacy of pyrethroids and coumaphos caused by resistance evolution. The continued application of amitraz in recent years exerts a very high selection pressure on mites, favouring the evolution of resistance to this acaricide. Mutations N87S and Y215H in the β2‐adrenergic‐like octopamine receptor (Octβ2R), target site of amitraz, have been already associated with resistance to amitraz in France and the USA, respectively.RESULTSA new mutation (F290L) in the Octβ2R of V. destructor has been found in mites from Spanish apiaries. The frequency of L290 mutated alleles in colonies increased after consecutive treatments with amitraz. In a field trial, mites from colonies with higher frequency of L290 mutated allele took longer to die compared with those carrying a higher proportion of the wild‐type allele. Lower susceptibility to amitraz was found in apiaries with a high frequency of homozygous mutants.CONCLUSIONOur data indicate the association of the F290L mutation in the octopamine receptor with resistance to amitraz in Spanish populations of V. destructor. Determining the frequency of mutant mites in apiaries may be important for predicting the efficacy of amitraz treatment in the field and would help design appropriate resistance management. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
MicroRNA expression alteration in chronic thromboembolic pulmonary hypertension: A systematic review
Authors: Sulastomo Heru , Dinarti Lucia Kris , Hariawan Hariadi , Haryana Sofia Mubarika 
Published: September 2024

AbstractChronic thromboembolic pulmonary hypertension (CTEPH) is marked by persistent blood clots in pulmonary arteries, leading to significant morbidity and mortality. Emerging evidence highlights the role of microRNAs (miRNAs) in pulmonary hypertension, though findings on miRNA expression in CTEPH remain limited and inconsistent. This systematic review evaluates miRNA expression changes in CTEPH and their direction. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, we registered our protocol in International Prospective Register of Systematic Reviews (CRD42024524469). We included studies on miRNA expression in CTEPH with comparative or analytical designs, excluding nonhuman studies, interventions, non‐English texts, conference abstracts, and editorials. Databases searched included PubMed, EMBASE, Scopus, CENTRAL, and ProQuest. The Quality Assessment of Diagnostic Accuracy Studies‐2 tool assessed bias risk, and results were synthesized narratively. Of 313 unique studies, 39 full texts were reviewed, and 9 met inclusion criteria, totaling 235 participants. Blood samples were analysed using quantitative real time polymerase chain reaction. Seven miRNAs (miR‐665, miR‐3202, miR‐382, miR‐127, miR‐664, miR‐376c, miR‐30) were uniformly upregulated, while nine (miR‐20a‐5p13, miR‐17‐5p, miR‐93‐5p, miR‐22, let‐7b, miR‐106b‐5p, miR‐3148, miR‐320‐a, miR‐320b) were downregulated in CTEPH patients. Two upregulated miRNAs (miR‐127 and miR‐30a) were consistently associated with previous evidence in the mechanism inducing the development of CTEPH, and five downregulated miRNAs (miR‐20‐a, miR‐17‐5p, miR‐93‐5p, let‐7b, miR‐106b‐5p) were associated with a protective effect against CTEPH. We also identified gaps in the literature where the evidence for five upregulated miRNAs (miR‐665, miR‐3202, miR‐382, miR‐664 and miR‐376c) and four downregulated miRNAs (miR‐22, miR‐3148, miR‐320‐a, and miR‐320b) in CTEPH is conflicting. Our findings offer insights into the role of miRNAs in CTEPH and underscore the need for further research to validate these miRNAs as biomarkers or therapeutic targets.
Causes and obstetric factors associated with timing of neonatal deaths in Soweto, South Africa
Authors: Chikandiwa Admire , Mahtab Sana , Nakwa Firdose L. , Umuneza Nadia , Baillie Vicky , Dangor Ziyaad , Velaphi Sithembiso , Adam Yasmin , Wise Amy 
Published: September 2024

AbstractObjectiveDescribe characteristics of women whose decedents died during the neonatal period and explore factors associated with postnatal age at time of death.MethodsAnalysis of data collected at the Child Health and Mortality Prevention Surveillance (CHAMPS) South Africa study site. CHAMPS generates cause of death data in children across nine sites in low‐ and middle‐income countries. Postnatal age at time of neonatal death was evaluated by Kaplan–Meier methods. Factors associated with time to neonatal death were evaluated using Cox proportional hazards regression models. Analyses were conducted in Stata 15.0®. p < 0.05 was considered statistically significant.ResultsThere were 225 neonatal deaths during the study period, of which 197 (87.5%) had data for mother‐neonate pairs, with 184 (81.7%) neonates having complete data. The median (IQR) maternal age at booking was 27 (23–34) years. Majority (72.3%, 142/197) of women were unmarried, unemployed (76.0%, 149/197) and were booked (85.0%, 141/166). There were 19.5% of women who had hypertensive disorders of pregnancy (HDP, 36/184) while 2.7% (5/184) had diabetes mellitus and 31.5% (58/184) were HIV positive. Most were early neonatal deaths (ENND; 79.4%, 146/184) and remainder (20.6%, 38/184) late neonatal deaths (LNND). The main underlying causes of death were prematurity (60.3%, 111/184), intrapartum hypoxia (17.4%, 32/184), neonatal sepsis (10.3%, 19/184) and congenital anomalies (9.2%, 17/184). Intrapartum hypoxia (Adjusted Hazard Ratio [aHR] = 2.01, 95% CI: 1.23–3.27, p = 0.01), assisted‐vaginal delivery compared to normal vaginal delivery (aHR = 1.96, 95% CI: 1.03–3.71, p = 0.04), preterm delivery (aHR = 1.62, 95% CI: 1.03–2, p = 0.04), Apgar score <7 at 5 min (aHR = 1.59, 95% CI: 1.01–2.31, p = 0.02) and a previous neonatal death ([aHR] = 1.33; 95% CI: 1.10–1.89, p = 0.04) were associated with earlier time to neonatal death.ConclusionIntrapartum complications were associated with earlier time to neonatal death. Improving intrapartum care can reduce neonatal deaths.
A Precision Mixture Risk Model to Identify Adverse Drug Events in Subpopulations Using a Case‐Crossover Design
Authors: Shi Yi , Eadon Michael T. , Chen Yao , Sun Anna , Yang Yuedi , Chiang Chienwei , Donneyong Macarius , Su Jing , Zhang Pengyue 
Published: September 2024

ABSTRACTDespite the success of pharmacovigilance studies in detecting signals of adverse drug events (ADEs) from real‐world data, the risks of ADEs in subpopulations warrant increased scrutiny to prevent them in vulnerable individuals. Recently, the case‐crossover design has been implemented to leverage large‐scale administrative claims data for ADE detection, while controlling both observed confounding effects and short‐term fixed unobserved confounding effects. Additionally, as the case‐crossover design only includes cases, subpopulations can be conveniently derived. In this manuscript, we propose a precision mixture risk model (PMRM) to identify ADE signals from subpopulations under the case‐crossover design. The proposed model is able to identify signals from all ADE‐subpopulation‐drug combinations, while controlling for false discovery rate (FDR) and confounding effects. We applied the PMRM to an administrative claims data. We identified ADE signals in subpopulations defined by demographic variables, comorbidities, and detailed diagnosis codes. Interestingly, certain drugs were associated with a higher risk of ADE only in subpopulations, while these drugs had a neutral association with ADE in the general population. Additionally, the PMRM could control FDR at a desired level and had a higher probability to detect true ADE signals than the widely used McNemar's test. In conclusion, the PMRM is able to identify subpopulation‐specific ADE signals from a tremendous number of ADE‐subpopulation‐drug combinations, while controlling for both FDR and confounding effects.
Harnessing Virtual Insights: A Computational Study on the Molecular Characterization of a Drought‐Inducible RNA‐Binding Protein for Enhancing Drought Tolerance in Mungbean (Vigna radiata L.)
Authors: Rajkhowa Sanchaita , Zaheen Alaiha , Hussain Safrina Zeenat , Barthakur Sharmistha 
Published: September 2024

AbstractAbiotic stresses, particularly drought and salinity, significantly impact agricultural crop yields, with mung bean (Vigna radiata L.) being no exception. This annual green legume, vital to agricultural systems in Asia, is generally resilient to limited water supply; however, severe drought conditions at critical growth stages can drastically diminish both its quality and yield. Drought stress negatively affects various morpho‐physicochemical properties, impeding plant growth and highlighting the need for sustainable approaches to enhance mung bean's drought tolerance through improved farming practices. In this study, we focused on identifying and understanding the molecular mechanisms underlying drought tolerance in mung beans. We retrieved the target gene sequence from the NCBI database, but found no direct sequence similarity, which led to the use of homology modeling. The structure of a known protein (PDB ID: 5T9P) was identified as the most suitable template. Motif prediction using the Motif Search tool highlighted specific motifs relevant to drought stress responses. To investigate potential drought‐tolerance mechanisms, we screened ABA agonists using Density Functional Theory (DFT) analysis. Molecular docking and MD simulations revealed the interactions between these ligands and the modeled protein, shedding light on how they might influence drought tolerance. We performed molecular dynamics (MD) simulations to assess the stability and conformational dynamics of the modeled protein across different time scales. Our findings underscore the potential of ABA agonists to modulate physiological responses and enhance drought resistance. This research offers valuable insights into the conformational dynamics of drought‐related proteins in mung beans, elucidating the molecular underpinnings of drought response mechanisms. By advancing our understanding of these processes, our findings provide novel strategies for improving breeding approaches aimed at enhancing crop resilience against water scarcity and other abiotic stresses. This work promises to mitigate the detrimental effects of drought on mung bean yields and supports sustainable agricultural practices, thereby contributing to global food security.
Anticancer Activity of Biogenically Synthesized Selenium Nanoparticles Using Catharanthus Roseus
Authors: Elumalai Velmurugan , Ramdoss Ramya , Padmanaban Rajashree 
Published: September 2024

AbstractThe aim of this paper was (1) to study the green synthesis of selenium nanoparticles (SeNPs) using whole plant extract of Catharanthus roseus (CR or C. roseus) known to have anticancer effects, (2) to investigate the induction of cell death by CR synthesized SeNPs (CR‐SeNPs) in lung cancer cell line (A549), and (3) to compare their anticancer potential with commercial SeNPs. The formation of polycrystalline CR‐SeNPs with absorption maxima of 275 nm, needle shaped nanorods, with mean diameter of 95 nm and −45mv zeta was demonstrated by XRD, UV‐vis spectroscopy, SEM, and zeta potential measurements. The presence of functional group from CR biomolecules was observed in CR‐SeNPs by FTIR. Cytotoxicity assay against A549 cancer cell line indicated potent anticancer activity (IC50 = 23.180 ± 0.140 µg) for CR‐SeNPs and mechanism of induction of cell death was found to be mediated through apoptotic phenomena through reactive oxygen species (ROS) generation. Notably, a significant increase in apoptosis was observed in the cells treated with CR‐SeNPs than commercial SeNPs treated cells. Nevertheless, lack of toxicity was observed in in vitro (hemolysis assay) and in vivo models. Biologically synthesized nanoparticles may possess higher anticancer properties than commercial SeNPs due to synergism of phytochemicals from CR and SeNPs. Further investigation in the therapeutic mechanisms of CR‐SeNPs is warranted in the in vivo conditions.