bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Sustainable Model for Patient follow-up following an International Cleft Mission
Authors: Wes Ari M. , Paul Nadine , Gerety Patrick A. , Folsom Nancy , Swanson Jordan , Taylor Jesse A. , Weinstein Mark H. 
Published: January 2017

Purpose: Patient follow-up after cleft missions is imperative if we are to critically assess the quality of care provided in these settings. The adoption of mobile telephones among disadvantaged families abroad may enable such an undertaking in a cost-effective manner. This project aimed to assess the efficacy of cellular phone-based follow-up in a developing country following a cleft mission to Thailand. Methods: Changing Children's Lives Inc. performed a cleft surgical mission to Udon Thani, Thailand, in January 2013. Telephone numbers collected at that time were used to survey the patients or their parents 1.5 years postoperatively. Results: Of the 56 patients who underwent cleft lip and/or palate surgery during the mission, more than 50% ( n = 30, 54%) were reachable by telephone; all chose to participate in the study. The cost for families was U.S. $124.92 (56.15); 26 families (87%) believed their money was well spent. Follow-up care was received by 22 (73%) patients, and all but one family ( n = 29, 97%) felt that their child received all of the medical care and support required. All families ( N = 30) would recommend similar cleft care to a friend. Of the patients younger than 18 years of age ( n = 24, 80%), 20 (80%) families found their child more comfortable interacting with peers, more comfortable interacting with adults, and more confident postoperatively. Conclusion: In one month, a survey response rate of more than 50% was obtained by leveraging the increased adoption of mobile phones in rural settings. Nearly all patients/families treated during the cleft mission were satisfied with the care that they received.
Um estudo do ethos em discursos do ex-presidente Lula
Authors: Tomaz Natália Rocha Oliveira , Gouvêa Lúcia Helena Martins 
Published: January 2017

Resumo: Este artigo tem por objetivo investigar, pela análise de discursos não oficiais do ex-presidente Luiz Inácio Lula da Silva, a hipótese de que haja, no corpus em questão, a predominância de um ethos popular para a sua figura. Para tanto, este estudo apoiou-se na Semiolinguística do Discurso como corrente teórica e buscou identificar traços relacionados ao ethos do líder político nos discursos analisados. O método para obtenção dos resultados obedeceu, primeiramente, à seleção qualitativa de dados. Em seguida, essas informações foram agrupadas quantitativamente de acordo com a frequência dos fenômenos encontrados. Dessa forma, foi possível concluir que o ethos de Lula se mostrou, essencialmente, popular, criado a partir de uma imagem de chefe oriundo do povo, de cenografias voltadas para o auditório de cada discurso, de argumentações baseadas em apelos emocionais e de metáforas elaboradas a partir de traços presentes na cultura brasileira. Palavras-chave: semiolinguística do discurso; ethos; discurso político; Lula.Abstract: This article aims to analyze – through the analysis of unofficial speeches of former Brazilian President Luiz Inácio Lula da Silva – the hypothesis of a popular ethos for his figure. Therefore, this study relied on the Discourse Semiolinguistics as theoretical basis and sought to identify features related to the ethos of the political leader in the analyzed discourses. For this purpose, firstly the method for obtaining the results was based on qualitative data selection. Then, this information was grouped quantitatively according to the frequency of the phenomena found. Thus, we concluded that the popular Lula’s ethos was built essentially from a chief image coming from the people, sets built depending on the audience of each speech, the arguments based on emotional appeals and metaphors elaborated from traits present in Brazilian culture.Keywords: Discourse Semiolinguistics; Ethos; Political Discourse; President Lula.
Clinical genetics and India
Authors: Shah Krati 
Published: January 2017

<span lang="en-US">India, with a population of 1.21 billion, having diverse origins is the second most populous country in the world. Clinical genetics/medical genetics, the “latest” branch is still in its infancy stage as compared to other developed countries. For the last 10</span><span lang="ar-SA"> year</span><span lang="en-US">s, there has been an increase in awareness, but it still remains a subject of less interest for majority of the professionals working in healthcare.</span>
ФУНКЦИОНАЛНО ПОВЕЗИВАЊЕ НАСТАВЕ ЈЕЗИКА И КЊИЖЕВНОСТИ
Authors: Аврамовић Стефан Д. 
Published: January 2017

У раду се разматрају начини на које се сврсисходно, методички промишљено могу повезати настава српског језика и настава књижевности. Даље се у ту сврху наводе примери из књижевних текстова за ученике петог разреда основне школе који се могу употребити на часовима обраде наставних јединица везаних за граматику и правопис.
Примери на којима се обрађују језичке појаве имају естетске вредности и ученицима су познати, стога им, природно, олакшавају разумевање и описивање уочених језичких појава. На тај начин постиже се двострука корист и у настави језика и у настави књижевности. Сем тога, ученици не само што успевају да уоче и опишу језичке појаве и правописне законитости већ су у прилици и да их схвате, да разумеју њихову суштину.
MORFOLOŠKE, SINTAKSIČKE I LEKSIČKE GREŠKE UČENIKA ČIJI JE MATERNJI JEZIK SRPSKI PRI USVAJANJU SLOVAČKOG KAO BLISKOG SLOVENSKOG JEZIKA
Authors: Uhlarik Jasna S. , Tirova Zuzana M. 
Published: January 2017

Predmet ovog rada su tipične jezičke greške koje se javljaju kod polaznika početnog kursa slovačkog jezika (kao stranog) čiji je maternji jezik srpski. U radu su kroz opis slovačkog jezičkog sistema posmatrane, zabeležene i analizirane tipične morfološke, sintaksičke i leksičke greške polaznika s osvrtom na odsustvo ili razlike u vezi sa funkcionisanjem pojedinih jezičkih pojava: paralele, slaganja i sličnosti nasuprot diferencijama, razlikama i kontrastima u slovačkom i srpskom jeziku. Cilj ovog rada jeste da se rezultati istraživanja primene u nastavi, kao i tokom određivanja adekvatne didaktičke koncepcije i metodičkih postupaka u nastavi.
NASTAVA JEZIKA ZA POSEBNE NAMENE KAO ZASEBNO PODRUČJE DIDAKTIKE
Authors: Radojković Ilić Katarina B. 
Published: January 2017

Predmet ovog rada je analiza pojedinih specifičnosti nastave stranog jezika za posebne namene u kojoj su aktivnosti usmerene više ka osposobljavanju učenika za izvršavanje profesionalnih zadataka koji uključuju upotrebu jezika nego ka usvajanju jezičkih elemenata. Izdvajanje pojedinih kompetencija u zavisnosti od potreba učenika, nepostojanje unapred utvrđene gramatičke progresije, pridavanje posebnog značaja razvoju sociolingvističke, interkulturne i različitih vanjezičkih kompetencija učenika, posebna uloga autentičnih dokumenata, specifična evaluacija i neprestano prilagođavanje svih didaktičkih elemenata potrebama učenika neki su od elemenata koji su analizirani na primeru nastave francuskog jezika sa ciljem da se ukaže na postojanje značajnih razlika između nastave jezika za posebne namene i nastave opšteg jezika i na opravdanost izdvajanja metodike nastave jezika za posebne namene kao zasebnog područja didaktike.
Mobilidade urbana e direito à cidade: uma entrevista com Lúcio Gregori sobre transporte coletivo e Tarifa Zero
Authors: Fix Mariana , Ribeiro Giovani Espíndola , Prado André Doca 
Published: January 2017

Resumo: Neste artigo, apresentamos e discutimos uma entrevista realizada, em 2015, com Lúcio Gregori, proponente da Tarifa Zero em São Paulo. Buscamos compreender o surgimento da proposta, nos anos 1990, e seus desdobramentos. Para tanto, são analisadas algumas das manifestações de apoio e resistência à aprovação da proposta, assim como sua formulação técnica, os jogos de interesses nela envolvidos e as modalidades de financiamento que a viabilizariam. São examinadas, igualmente, as características do “negócio” do transporte e das empresas que atuam em tal setor. Situamos a proposta da Tarifa Zero no debate sobre mobilidade urbana, relacionando-a com a luta pelo Direito à Cidade. Além disso, discutimos a hegemonia do transporte individual privado e algumas de suas consequências.Palavras-chave: mobilidade urbana; tarifa zero; direito à cidade; ônibus; transporte coletivo. Urban mobility and the right to the city: an interview with Lucio Gregori on (free) public transportAbstract: In this article, we present and discuss an interview with Lúcio Gregori, in 2015, the proposer of the Tarifa Zero (Zero-Fare Public Transit) Bill. We seek to understand the emergence of the proposal, in the 1990s, and its consequences. Therefore, we discuss some of the expressions of support and resistance to the adoption of the proposal, as well as its technical formulation, the power games involved, and the financing arrangements that would allow it. The characteristics of the “business” of transport and of the companies operating in this sector are also examined. We situate the proposal of Zero-Fare in the debate on urban mobility, linking it to the struggle for the right to the city. In addition, we discuss the hegemony of private individual transport and some of its consequences.Keywords: urban mobility; Zero-Fare; right to the city; bus; public transport.
Early and late epilepsy surgery in focal epilepsies associated with long-term epilepsy-associated tumors
Authors: Pelliccia Veronica , Deleo Francesco , Gozzo Francesca , Sartori Ivana , Mai Roberto , Cossu Massimo , Tassi Laura 
Published: January 2017

OBJECTIVEEpilepsy surgery is an effective means of treating focal epilepsy associated with long-term epilepsy-associated tumors. This study evaluated a large population of surgically treated patients with childhood onset of epilepsy and a histologically confirmed diagnosis of long-term epilepsy-associated tumors. The authors analyzed long-term seizure outcomes to establish whether the time of surgery and patients' ages were determinant factors.METHODSThe authors separately investigated several presurgical, surgical, and postsurgical variables in patients operated on before (pediatric group) and at or after (adult group) the age of 18 years. Patients with < 24 months of postsurgical follow-up were excluded from the analysis.RESULTSThe patients who underwent surgery before 18 years of age showed better seizure outcomes than those after 18 years of age (80% vs 53.3% Engel Class Ia outcome, respectively; p < 0.001). Multivariate analysis showed that the only variables significantly associated with seizure freedom were complete resection of the lesion, a shorter duration of epilepsy, and temporal lobe resection.CONCLUSIONSThe findings of this study indicate that pediatric patients are more responsive to epilepsy surgery and that a shorter duration of epilepsy, complete resection, and a temporal lobe localization are determinant factors for a positive seizure outcome.
Academic impact and rankings of neuroendovascular fellowship programs across the United States
Authors: Sonig Ashish , Shallwani Hussain , Levy Bennett R. , Shakir Hakeem J. , Siddiqui Adnan H. 
Published: January 2017

OBJECTIVEPublication has become a major criterion of success in the competitive academic environment of neurosurgery. This is the first study that has used departmental h index–and e index–based matrices to assess the academic output of neuroendovascular, neurointerventional, and interventional radiology fellowship programs across the continental US.METHODSFellowship program listings were identified from academic and organization websites. Details for 37 programs were available. Bibliometric data for these programs were gathered from the Thomson Reuters Web of Science database. Citations for each publication from the fellowship's parent department were screened, and the h and e indices were calculated from non–open-surgical, central nervous system vascular publications. Variables including “high-productivity” centers, fellowship–comprehensive stroke center affiliation, fellowship accreditation status, neuroendovascular h index, e index (h index supplement), h10 index (publications during the last 10 years), and departmental faculty-based h indices were created and analyzed.RESULTSA positive correlation was seen between the neuroendovascular fellowship h index and corresponding h10 index (R = 0.885; p < 0.0001). The mean, median, and highest faculty-based h indices exhibited positive correlations with the neuroendovascular fellowship h index (R = 0.662, p < 0.0001; R = 0.617, p < 0.0001; and R = 0.649, p < 0.0001, respectively). There was no significant difference (p = 0.824) in the median values for the fellowship h index based on comprehensive stroke center affiliation (30 of 37 programs had such affiliations) or accreditation (18 of 37 programs had accreditation) (p = 0.223). Based on the quartile analysis of the fellowship h index, 10 of 37 departments had an neuroendovascular h index of ≥ 54 (“high-productivity” centers); these centers had significantly more faculty (p = 0.013) and a significantly higher mean faculty h index (p = 0.0001).CONCLUSIONSThe departmental h index and analysis of its publication topics can be used to calculate the h index of an associated subspecialty. The analysis was focused on the neuroendovascular specialty, and this methodology can be extended to other neurosurgical subspecialties. Individual faculty research interest is directly reflected in the research productivity of a department. High-productivity centers had significantly more faculty with significantly higher individual h indices. The current systems for neuroendovascular fellowship program accreditation do not have a meaningful impact on academic productivity.
Five species, many genotypes, broad phenotypic diversity: When agronomy meets functional ecology
Authors: Prieto Ivan , Litrico Isabelle , Violle Cyrille , Barre Philippe 
Published: January 2017

PREMISE OF THE STUDY:Current ecological theory can provide insight into the causes and impacts of plant domestication. However, just how domestication has impacted intraspecific genetic variability (ITV) is unknown. We used 50 ecotypes and 35 cultivars from five grassland species to explore how selection drives functional trait coordination and genetic differentiation.METHODS:We quantified the extent of genetic diversity among different sets of functional traits and determined how much genetic diversity has been generated within populations of natural ecotypes and selected cultivars.KEY RESULTS:In general, the cultivars were larger (e.g., greater height, faster growth rates) and had larger and thinner leaves (greater SLA). We found large (average 63%) and trait‐dependent (ranging from 14% for LNC to 95.8% for growth rate) genetic variability. The relative extent of genetic variability was greater for whole‐plant than for organ‐level traits. This pattern was consistent within ecotypes and within cultivars. However, ecotypes presented greater ITV variability.CONCLUSIONS:The results indicated that genetic diversity is large in domesticated species with contrasting levels of heritability among functional traits and that selection for high yield has led to indirect selection of some associated leaf traits. These findings open the way to define which target traits should be the focus in selection programs, especially in the context of community‐level selection.
Atmospheric moisture supersaturation in the near-surface atmosphere at Dome C, Antarctic Plateau
Authors: Genthon Christophe , Piard Luc , Vignon Etienne , Madeleine Jean-Baptiste , Casado Mathieu , Gallée Hubert 
Published: January 2017

Abstract. Supersaturation often occurs at the top of the troposphere where cirrus clouds form, but is comparatively unusual near the surface where the air is generally warmer and laden with liquid and/or ice condensation nuclei. One exception is the surface of the high Antarctic Plateau. One year of atmospheric moisture measurement at the surface of Dome C on the East Antarctic Plateau is presented. The measurements are obtained using commercial hygrometry sensors modified to allow air sampling without affecting the moisture content, even in the case of supersaturation. Supersaturation is found to be very frequent. Common unadapted hygrometry sensors generally fail to report supersaturation, and most reports of atmospheric moisture on the Antarctic Plateau are thus likely biased low. The measurements are compared with results from two models implementing cold microphysics parameterizations: the European Center for Medium-range Weather Forecasts through its operational analyses, and the Model Atmosphérique Régional. As in the observations, supersaturation is frequent in the models but the statistical distribution differs both between models and observations and between the two models, leaving much room for model improvement. This is unlikely to strongly affect estimations of surface sublimation because supersaturation is more frequent as temperature is lower, and moisture quantities and thus water fluxes are small anyway. Ignoring supersaturation may be a more serious issue when considering water isotopes, a tracer of phase change and temperature, largely used to reconstruct past climates and environments from ice cores. Because observations are easier in the surface atmosphere, longer and more continuous in situ observation series of atmospheric supersaturation can be obtained than higher in the atmosphere to test parameterizations of cold microphysics, such as those used in the formation of high-altitude cirrus clouds in meteorological and climate models.
Fram Strait sea ice export variability and September Arctic sea ice extent over the last 80 years
Authors: Smedsrud Lars H. , Halvorsen Mari H. , Stroeve Julienne C. , Zhang Rong , Kloster Kjell 
Published: January 2017

Abstract. A new long-term data record of Fram Strait sea ice area export from 1935 to 2014 is developed using a combination of satellite radar images and station observations of surface pressure across Fram Strait. This data record shows that the long-term annual mean export is about 880 000 km2, representing 10 % of the sea-ice-covered area inside the basin. The time series has large interannual and multi-decadal variability but no long-term trend. However, during the last decades, the amount of ice exported has increased, with several years having annual ice exports that exceeded 1 million km2. This increase is a result of faster southward ice drift speeds due to stronger southward geostrophic winds, largely explained by increasing surface pressure over Greenland. Evaluating the trend onwards from 1979 reveals an increase in annual ice export of about +6 % per decade, with spring and summer showing larger changes in ice export (+11 % per decade) compared to autumn and winter (+2.6 % per decade). Increased ice export during winter will generally result in new ice growth and contributes to thinning inside the Arctic Basin. Increased ice export during summer or spring will, in contrast, contribute directly to open water further north and a reduced summer sea ice extent through the ice–albedo feedback. Relatively low spring and summer export from 1950 to 1970 is thus consistent with a higher mid-September sea ice extent for these years. Our results are not sensitive to long-term change in Fram Strait sea ice concentration. We find a general moderate influence between export anomalies and the following September sea ice extent, explaining 18 % of the variance between 1935 and 2014, but with higher values since 2004.
Cathepsin K Expression in Castration-Resistant Prostate Carcinoma: A Therapeutical Target for Patients at Risk for Bone Metastases
Authors: Munari Enrico , Cima Luca , Massari Francesco , Bertoldo Francesco , Porcaro Antonio Benito , Caliò Anna , Riva Giulio , Ciocchetta Elisa , Ciccarese Chiara , Modena Alessandra , Iacovelli Roberto , Sava Teodoro , Eccher Albino , Ghimenton Claudio , Tortora Giampaolo , Artibani Walter , Novella Giovanni , Bogina Giuseppe , Zamboni Giuseppe , Sanguedolce Francesca , D'Amuri Alessandro , Martignoni Guido , Brunelli Matteo 
Published: January 2017

Background The lysosomal cysteine protease cathepsin K is involved in bone remodeling and is also expressed in the peritumoral stroma of carcinomas arising from different organs. A new generation of cathepsin K inhibitors blocking the RANKL/RANK pathway are being developed. We sought to investigate cathepsin K expression in a cohort of castration-resistant prostate carcinomas. Methods Sixteen cases of castration-resistant disease with at least 5 years of follow-up were selected from a cohort of 280 patients who underwent surgery. Cathepsin K was evaluated on formalin-fixed and paraffin-embedded tissue microarrays with 5 tissue spots per case. These were scored as high 2+ (≥30% of cells), low 1+ (<30% of cells) or zero (absence), distinguishing tumor cells and peritumoral stroma cells. Low (1+) and absence (0) of scoring were interpreted as negative, and high (2+) as positive. Results The castration-resistant group was composed of 15 acinar adenocarcinomas and 1 neuroendocrine carcinoma, and all showed at least Gleason score 8 at prostatectomy. Two out of 16 cases (12%) scored positive for cathepsin K in tumor cells; and 5 of 16 cases (31%) scored positive in peritumoral stroma cells. The neuroendocrine and acinar subtypes of carcinoma with positive immunoexpression in neoplastic cells developed bone metastases after 4 and 5 years, respectively, and subsequently died. Conclusions Patients affected by castration-resistant prostate carcinoma may be tested for cathepsin K, and a positive strong expression (2+) could be a useful predictive biomarker of response to targeted agents, aiding in the selection of patients eligible for these treatments.
Comparison of Neoadjuvant vs Concurrent/Adjuvant Androgen Deprivation in Men with High-risk Prostate Cancer Receiving Definitive Radiation Therapy
Authors: Lee Anna , Becker Daniel J. , Lederman Ariel J. , Osborn Virginia W. , Shao Meng S. , Wong Andrew T. , Schwartz David , Schreiber David 
Published: January 2017

Purpose It is unknown whether there is a benefit to starting androgen deprivation therapy (ADT) prior to rather than concurrently with definitive radiation therapy in men with high-risk prostate cancer. We studied the National Cancer Data Base to determine whether the timing of ADT impacts survival. Methods Men diagnosed with high-risk prostate adenocarcinoma who received external beam radiation therapy (EBRT) to a dose of 70-81 Gy along with ADT from 2004-2011 were included. Those who started ADT 42-90 days before EBRT were identified as having received neoadjuvant hormonal therapy (N-HT) and those who received ADT from 14 days before their radiation until 84 days after the start of EBRT were categorized as receiving concurrent/adjuvant treatment (C-HT). We used the log-rank test to compare Kaplan-Meier survival curves and multivariable Cox regression to assess the impact of covariables on overall survival (OS). Results Among 11,491 included patients, those receiving N-HT were 1 year older ( p<0.001) and more likely to have Gleason 8-10 disease ( p = 0.01) and cT3-4 disease ( p = 0.002). Men receiving N-HT had a 5-year and median OS of 80.6% and 111.4 months, respectively, compared to 78.3% and 108.9 months, respectively, in those receiving C-HT ( p = 0.03). This benefit remained significant on multivariable analysis (hazard ratio 0.86, 95% confidence interval 0.77-0.96, p = 0.008). Duration of ADT was not available to report. Conclusions External beam radiation therapy with N-HT was associated with improved overall survival compared to C-HT. This study is hypothesis-generating and further studies are needed to best qualify the sequencing of hormone therapy with the duration of treatment.