bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Multiphase Concave Tetrahedral PdInMo Nanocatalyst for Enhanced Alcohol Oxidation
Authors: Guo Qiaoqin , Dou Jingjing , Yang Xiaoxuan , Jiang Zitong , Wang Hui , Liu Yaming , Xie Haijiao , Li Xiang 
Published: October 2024

AbstractHeterogeneous palladium‐based catalysts show excellent catalytic properties for electrocatalytic oxidation of alcohols, but the construction of such heterogeneous catalysts is a challenge. Here, a multiphase tetrahedral PdInMo nanocatalyst is prepared by a one‐pot reaction method. And the multiphase tetrahedral PdInMo nanocatalyst consists of a face‐centered cubic structure and an intermetallic structure. Due to the oxygen affinity of indium and molybdenum atoms, the interface defects of internal multiphase structure, and intermetallic structure, the multiphase concave tetrahedral PdInMo nanocatalyst shows enhanced catalytic efficiency in the electrocatalytic oxidation reaction of methanol and ethanol. Compared with commercial Pd/C catalysts, PdIn0.117Mo0.037 nanocatalyst has the best mass activity and specific activity. In electrocatalysis of methanol oxidation, the mass activity (2205.57 mA mgPd−1) and specific activity (6.67 mA cm−2) are 4.81 and 3.40 times than that of a commercial Pd/C nanocatalyst (458.5 mA mgPd−1, 1.96 mA cm−2), respectively. In the electrocatalysis of ethanol oxidation, the mass activity (2668.49 mA mgPd−1) and specific activity (8.11 mA cm−2) are 4.06 and 3.14 times than that of the commercial Pd/C nanocatalyst (655.83 mA mgPd−1, 2.58 mA cm−2), respectively. This study provides a reference for the design of highly efficient palladium catalysts for alcohol oxidation.
Targeted Defect Repair and Multi‐functional Interface Construction for the Direct Regeneration of Spent LiFePO4 Cathodes
Authors: Cao Yang , Li Junfeng , Tang Di , Zhou Fei , Yuan Mengwei , Zhu Yanfei , Feng Chengzhi , Shi Ruyu , Wei Xijun , Wang Boran , Song Yingze , Cheng Hui‐Ming , Zhou Guangmin 
Published: October 2024

AbstractDue to the low economic benefits and environmental pollution of traditional recycling methods, the disposal of spent LiFePO4 (SLFP) presents a significant challenge. The capacity fade of SLFP cathode is primarily caused by lithium loss and formation of a Fe (III) phase. Herein, a synergistic repair effect is proposed to achieve defect repair and multi‐functional interface construction for the direct regeneration of SLFP. Tannic acid (TA) forms a compact coating precursor for a carbon layer on SLFP with abundant functional groups and creates a mildly acidic environment to enhance the reducibility of thiourea (TU). Therefore, TU reduces Fe (III) to Fe (II) and repairs Li‐Fe anti‐site defects of SLFP, while at the same time acting as a source of N/S‐doping elements for the carbon layer at a lower temperature (140 °C). The multi‐functional carbon layer improves the properties of the regenerated LiFePO4 (RLFP) due to the enhanced conductivity, structure maintenance and protection, and the improved kinetics of Li+ transport. Furthermore, the Fe─O and P─O bonds are strengthened, further enhancing the structural stability of the RLFP. Consequently, the RLFP demonstrates outstanding performance with a discharge capacity of 141.3 mAh g−1 and capacity retention of 72% after 1000 cycles at 1 C.
Enhancing Corrosion Resistance and Tribomechanical Characteristics of Powder Coatings via the Integration of Functionalized HF‐Free MXene Reinforcements
Authors: Nazarlou Ziba , Peighambardoust Naeimeh Sadat , Motlagh Peyman Lahe , Aydemir Umut 
Published: October 2024

AbstractMXene, a new generation of 2D materials, is gaining attention for anti‐corrosion applications due to its large surface area, electrical conductivity, and self‐healing properties. Its low shear strength and self‐lubricating properties enhance wear resistance. Herein, silane functionalized HF‐Free MXene nanosheets “MS‐f_Ti3C2 and MS‐f_Ti3C2@Zn” synthesized through the molten salt method are integrated into the environmentally sustainable powder coating. The electrochemical tests indicate that a powder coating containing a well‐dispersed 1.5 wt.% f_Ti3C2@Zn nanosheets exhibit the highest polarization resistance (1.1 × 106 Ω cm2), lowest Icorr (2.15 × 10−8 A cm−2) and superior anti‐corrosion performance after 42 days of immersion in 3.5 wt.% NaCl. The polarization resistance (Rp) and corrosion current (Icorr) of the untreated coating are measured to be 1.6 × 103 Ω cm2 and 1.6 × 10−5A cm−2, respectively. In addition, the incorporation of MXene material reduces crack development and spalling, and enhances wear resistance during the friction process. The loading of 1.5 wt.% f_Ti3C2@Zn reduces the coefficient of friction (COF) and improves wear rate by 45% and 51%, respectively Analysis of composites via nanoindentation reveals such enhanced mechanical properties. This study presents an effective and sustainable approach to improve the mechanical, tribological, and long‐term corrosion protection of organic coating, thereby exhibiting great potential for using HF‐Free MXene as a multipurpose additive.
Fe(III)‐Catalyzed Intramolecular Hydroamination of 1,3‐Dienes Improved by Using Triphenylphosphate as an Additive
Authors: Kim Ye Jin , Kim Dong Bin , Youn So Won 
Published: October 2024

AbstractWe herein report that the combination of Fe(OTf)3 and triphenylphosphate (TPP, (PhO)3PO) has proven to be an effective catalyst for the intramolecular hydroamination of amino‐1,3‐dienes with an efficiency and scope superior to previously reported methods. This catalytic system demonstrated consistent performance with diverse aminodienes as well as aminoolefins, providing five‐ to seven‐membered N‐heterocycles. We propose a Lewis/Brønsted acid cocatalysis mechanism involving proton transfer through hydrogen bonding with TPP. Catalyst system consisting of inexpensive and nontoxic iron salt and phosphate additive, relatively low loading and recyclability of catalyst, and rapid and high‐yielding reaction are the advantages of this protocol.
Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics
Authors: Gao Jingjing , Nutan Bhingaradiya , Gargouri Dorra , Pisal Nishkal D. , Do Vy , Zubair Muhammad , Alanzi Hommam , Wang Hiqui , Lee Dongtak , Joshi Nitin , Ullah Aman 
Published: October 2024

AbstractNucleic acid therapeutics have demonstrated tremendous potential for treating diseases by targeting the genetic underpinnings at the transcriptomic level. However, their efficacy hinges on robust strategies to protect nucleic acids from degradation during circulation and to facilitate precise delivery to diseased tissues and cells. Here the critical roles of chemical modification and bioconjugation in advancing nucleic acid therapeutics for improved binding affinity, enhanced stability, and targeted delivery are reviewed. Commencing diverse applications, the significance of different chemical modifications is discussed based on recent literature and clinical products, on oligonucleotides. These modifications encompass backbone, ribose, base alterations and bioconjugation techniques such as N‐acetylgalactosamine (GAlNac), aptamers, antibodies, and cell‐penetrating peptides (CPPs). Supported by a clinical perspective, diverse applications and ongoing developments are highlighted. Furthermore, the current landscape of nucleic acid therapeutics and their potential in addressing genetic disorders with multiple cellular/organelle targeting is discussed. Here the promising prospect of combining chemical innovation and bioconjugation strategies is underscored to propel the development of more effective nucleic acid therapeutics.
Efficacy of lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery for rectal cancer
Authors: Takahashi Hidekazu , Saso Kazuhiro , Ohue Masayuki , Noura Shingo , Tanida Tsukasa , Komori Takamichi , Tei Mitsuyoshi , Kagawa Yoshinori , Morita Shunji , Okamura Shu , Miyake Masakazu , Miyoshi Norikatsu , Uemura Mamoru , Fujii Makoto , Ohno Yuko , Yamamoto Hirofumi , Murata Kohei , Doki Yuichiro , Eguchi Hidetoshi ,   Clinical Study Group of Osaka University, Colorectal Cancer Treatment Group (CSGOCG)
Published: October 2024

AbstractObjectiveWe investigated how Japanese D3 dissection with left colic artery (LCA) preservation affects anastomotic leakage after anterior resection with anastomosis for rectal cancer, based on the leak rate. The correlation between LCA preservation, survival, and cancer recurrence after resection was also analyzed.Summary and Background DataIt remains unclear how LCA preservation affects the anastomotic leak rate and oncological outcomes after resection remains unclear. Some reports suggested that anastomotic leakage increases local recurrence and decreases cancer‐specific survival.MethodsIn this study, we enrolled and analyzed 457 patients who underwent radical resection of rectal cancer in the period October 2011 through December 2016. The attending surgeon decided preoperatively and registered whether to preserve the LCA. This trial was registered under the UMIN‐CTR Identifier UMIN000006160.ResultsD3 with LCA preservation was successfully completed in 218 (89.3%) of the 244 patients registered in this group, whereas D3 without LCA preservation was successfully completed in all 213 patients registered in this group. After propensity score matching, the anastomotic leakage rate was 7.86% (11/140) after D3 with LCA preservation and 7.14% (10/140) after D3 without LCA preservation. The overall survival rates were 90.1% and 89.3%, and the recurrence‐free survival rates were 77.6% and 77.3%, respectively.ConclusionsOur findings suggest that LCA preservation has no effect on the incidence of anastomotic leakage after rectal resection with anastomosis using DST and that oncological outcomes may not be affected.
Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease
Authors: Madsen Lasse S. , Ismail Rola , Parbo Peter , Kjeldsen Pernille L. , Schaldemose Jeppe L. , Hansen Kim V. , Gottrup Hanne , Aanerud Joel , Eskildsen Simon F. , Brooks David J. 
Published: October 2024

AbstractINTRODUCTIONMicroglial responses are an integral part of Alzheimer's disease (AD) pathology and are associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects of Aβ and microglial responses on global cognitive impairment.METHODSIn this longitudinal study, 28 patients with mild cognitive impairment and 11 healthy controls underwent 11C‐PK11195 and 11C‐Pittsburgh compound B positron emission tomography (PET), structural magnetic resonance imaging scans, and global cognitive ratings at baseline and 2‐year follow‐up. Correlations between PET uptake and global cognition were assessed. Additionally, the mediation effect of the microglial response on the association between Aβ load and global cognition was assessed.RESULTSAβ load and the microglial response were both independently detrimental to global cognitive performance at baseline; however, at 2‐year follow‐up the association between Aβ load and global cognitive ratings was partially mediated by the microglial response.DISCUSSIONAs AD progresses, the associated microglial response partially mediates the detrimental effect of aggregated Aβ on cognition.Highlights
This was a longitudinal study of amyloid beta (Aβ), microglial responses, and global cognitive performance.
Aβ and microglial responses both affect cognition in early Alzheimer's disease.
Microglial response partially mediates the effect of Aβ on cognition in later stages.
Implementation and validation of face de‐identification (de‐facing) in ADNI4
Authors: Schwarz Christopher G. , Choe Mark , Rossi Stephanie , Das Sandhitsu R. , Ittyerah Ranjit , Fletcher Evan , Maillard Pauline , Singh Baljeet , Harvey Danielle J. , Malone Ian B. , Prosser Lloyd , Senjem Matthew L. , Matoush Leonard C. , Ward Chadwick P. , Prakaashana Carl M. , Landau Susan M. , Koeppe Robert A. , Lee JiaQie , DeCarli Charles , Weiner Michael W. , Jack Clifford R. , Jagust William J. , Yushkevich Paul A. , Tosun Duygu ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: October 2024

AbstractINTRODUCTIONRecent technological advances have increased the risk that de‐identified brain images could be re‐identified from face imagery. The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a leading source of publicly available de‐identified brain imaging, who quickly acted to protect participants’ privacy.METHODSAn independent expert committee evaluated 11 face‐deidentification (“de‐facing”) methods and selected four for formal testing.RESULTSEffects of de‐facing on brain measurements were comparable across methods and sufficiently small to recommend de‐facing in ADNI. The committee ultimately recommended mri_reface for advantages in reliability, and for some practical considerations. ADNI leadership approved the committee's recommendation, beginning in ADNI4.DISCUSSIONADNI4 de‐faces all applicable brain images before subsequent pre‐processing, analyses, and public release. Trained analysts inspect de‐faced images to confirm complete face removal and complete non‐modification of brain. This paper details the history of the algorithm selection process and extensive validation, then describes the production workflows for de‐facing in ADNI.Highlights
ADNI is implementing “de‐facing” of MRI and PET beginning in ADNI4.
“De‐facing” alters face imagery in brain images to help protect privacy.
Four algorithms were extensively compared for ADNI and mri_reface was chosen.
Validation confirms mri_reface is robust and effective for ADNI sequences.
Validation confirms mri_reface negligibly affects ADNI brain measurements.
Ultra‐Tough Dynamic Supramolecular Ion‐Conducting Elastomer Induced Uniform Li+ Transport and Stabilizes Interphase Ensures Dendrite‐Free Lithium Metal Anodes
Authors: Liu Hong , Zhen Fengxu , Yin Xiangkai , Wu Yingbin , Yu Kailiang , Kong Xiangpeng , Ding Shujiang , Yu Wei 
Published: October 2024

AbstractArtificial polymer solid electrolyte interphases (SEIs) with microphase‐separated structures provide promising solutions to the inhomogeneity and cracking issues of natural SEIs in lithium metal batteries (LMBs). However, achieving homogeneous ionic conductivity, excellent mechanical properties, and superior interfacial stability remains challenging due to interference from hard‐phase domains in ion transport and solid‐solid interface issues with lithium metal. Herein, we present a dynamic supramolecular ion‐conducting poly (urethane‐urea) interphase (DSIPI) that achieves these three properties through modulating the hard‐phase domains and constructing a composite SEI in situ. The soft‐phase polytetrahydrofuran backbone, featuring loose Li+−O coordinating interactions, ensures uniform Li+ transport. Concurrently, sextuple hydrogen bonds in the hard phase dissipate strain energy through sequential bond cleavage, thereby imparting exceptional mechanical properties. Moreover, enriched bis (trifluoromethanesulfonyl) imide anion (TFSI−) in DSIPI promotes the in situ formation of a stable polymer‐inorganic composite SEI during cycling. Consequently, the DSIPI‐protected lithium anode (DSIPI@Li) enables symmetric cells with exceptional cyclability exceeding 4,000 hours at an ultra‐high current density of 20 mA cm−2, thereby demonstrating excellent cycling stability. Furthermore, DSIPI@Li facilitates stable operation of the pouch cells under the constraints of a high‐loading LiNi0.8Co0.1Mn0.1O2 cathode and low negative/positive capacity (N/P) ratio. This work presents a powerful strategy for designing artificial SEIs and high‐performance LMBs.
Denoising Medium Resolution Stellar Spectra With Neural Networks
Authors: Pál Balázs , Dobos László 
Published: October 2024

ABSTRACTWe trained denoiser autoencoding neural networks on medium resolution simulated optical spectra of late‐type stars to demonstrate that the reconstruction of the original flux is possible at a typical relative error of a fraction of a percent down to a typical signal‐to‐noise ratio of per pixel. We show that relatively simple networks are capable of learning the characteristics of stellar spectra while still flexible enough to adapt to different values of extinction and fluxing imperfections that modifies the overall shape of the continuum, as well as to different values of Doppler shift. Denoised spectra can be used to find initial values for traditional stellar template fitting algorithms and—since evaluation of pretrained neural networks is significantly faster than traditional template fitting—denoiser networks can be useful when a fast analysis of the noisy spectrum is necessary, for example during observations, between individual exposures.
Treatment preferences of patients with muscle invasive bladder cancer: A discrete choice experiment
Authors: Mannion Liam , Watson Verity , Mullassery Vinod , Nair Rajesh , Charlton Thomas , Northover Margaret , Enting Deborah , Van Hemelrijck Mieke , Khan Muhammad Shamim , Thurairaja Ramesh , Amery Suzanne , Chatterton Kathryn , Smith Kate , Hughes Simon 
Published: October 2024

AbstractBackgroundWhen faced with treatment options, patients are asked to participate in decision‐making. We sought to determine which treatment aspects matter most for individuals treated for muscle invasive bladder cancer (MIBC), with an aim to improve understanding of patient preferences and what trade‐offs patients are willing to accept. Our study consisted of a discrete choice experiment (DCE): a type of questionnaire used to elicit preferences in the absence of real‐world choice.MethodsThe DCE had five attributives, each with three levels. Participants were asked to complete a questionnaire in which they were asked to choose between two hypothetical MIBC treatments. The data were analysed using a conditional logit model, and preferences for, and trade‐offs between, attributes were estimated.ResultsWe recruited patients with MIBC who had either already completed, were undergoing or had yet to commence radical treatment for MIBC (n = 60). Participants indicated a strong preference for treatments that increased their life expectancy (p = <0.001), had a lower risk of long‐term complications (p = <0.001) and less changes to their body image (p = <0.001). Changes to sexual wellbeing (p = 0.09) or an increase in acute side effects (p = 0.99) did not influence preferences. Patients were willing to accept treatments with higher risk of long‐term complications to improve their life expectancy or body image.ConclusionWhen deciding on the type of treatment, increased life expectancy is the most important consideration for people with MIBC. The risk of long‐term complications and changes to overall body image as a result of treatment are also important. Our study also highlighted that patients are willing to accept a higher risk of long‐term complications to improve other treatment outcomes. Understanding patient preferences is important for shared decision‐making, which has an impact on quality of care for people living with MIBC.
Analysis of Antioxidants from Three Parts of Polygonum Chinense based on Online Extraction High Performance Liquid Chromatography Antioxidant Analysis System
Authors: Qian Zhengming , Huang Qi , Wu Mengqi , Yang Weiqi , Wei Zhixiong , Cheng Xinjie , Li Deqiang 
Published: October 2024

AbstractIn the current study, a rapid online extraction combined with high‐performance liquid chromatography (HPLC) antioxidant analysis approach was developed to explore the antioxidant ingredients in three different parts of Polygonum Chinense. A total of 22 chromatographic peaks were found, among which 8 components were found for the first time. And among these 22 peaks, 19 of them were demonstrated as antioxidants. Furthermore, all three parts from Polygonum Chinense exhibited antioxidant activity (13.19, 3.89, and 19.85 mg CE/g extract, for the leaf, stem, and flower, respectively) and the antioxidant activity values of the leaf and flower were more than 3 times that of the stem. The leaf, flower, and stem of Polygonum Chinense had 17, 13, and 15 antioxidant components, respectively. Among them, neochlorogenic acid (2) and quercetin‐3‐O‐malonylglucoside (18) were considered as the main antioxidants in the leaf of Polygonum Chinense. In terms of flower, geraniin (10) and quercetin‐3‐O‐malonylglucoside (18) were proved as the major antioxidants. This is the first report on the antioxidant components from different parts of Polygonum Chinense. It provides foundational scientific data for the continued exploration of chemical and pharmacological study of Polygonum Chinense, which is beneficial for the future product development and quality evaluation improvement of Polygonum Chinense.
Temperature‐Dependent Supramolecular Isomeric Co‐CPs for Luminescence Recognition and Catalytic Oxidation
Authors: Ji Mengna , Liu Tingting , Liu Nana , Hao Hongguo , Li Yunwu , Dou Jianmin , Duan Jingui , Wang Suna 
Published: October 2024

AbstractTwo Co‐based supramolecular isomers were synthesized from a fluorinated carboxylic acid ligand under hydrothermal conditions at varying temperatures. Both exhibited similar one‐dimensional chain structures while different bending connections of the aromatic rings led to different supramolecular structures, namely CoCP‐1 and CoCP‐2, respectively. The structural differences of two isomers resulted in discrepant performance with regards to luminescence sensing and catalysis. CoCP‐1 demonstrated more significant luminescence quenching activity toward biomarkers 2,6‐pyridinedicarboxylic acid (DPA) and homovanillic acid (HVA), which could be distinguished in the presence of Eu3+. The limit of detection (LOD) was found to be as low as 3.4 and 1.3 μM, respectively. The recovery rate of for HVA and DPA was within the range of 98.5–110.3 % and 84.6–99.3 % in simulated urine and serum, respectively, indicating potential reliability in monitoring these two analytes in real samples. Notably, CoCP‐2 exhibited catalytic activity for the oxidation of thioethers to sulfoxides. Our finding here suggests that the coordination conformation of the ligands within supramolecular isomers plays a pivotal role in determining the structure and luminescence sensing/catalysis performance.
Gallatabenzene Ligands Emerging from Open Lutetocene and Yttrocene Methyl Complexes
Authors: Lebon Jakob , Beauvois Maxime , Maichle‐Mössmer Cäcilia , Sirsch Peter , Anwander Reiner 
Published: October 2024

AbstractUtilizing ternary mixtures [LnMe3]n/K(2,4‐dtbp)/GaMe3 (Ln=Lu, Y; 2,4‐dtbp=2,4‐di‐tert‐butyl‐pentadienyl), a series of metallacycles is accessible via tandem salt metathesis/deprotonation. Depending on the precursor molar ratio, both gallatabenzene and lutetacyclic moieties with fully planar metallacycles are obtained, which were further analyzed using DFT calculations. The precursor molar ratio affects the extent of pentadienyl C−H‐bond activation and oligomerization to tetra‐ and pentametallic arrays. Reacting a 1 : 2 : 2 mixture at −40 °C gave the open sandwich methyl complex (2,4‐dtbp)2Lu(CH3), displaying a vital intermediate for subsequent ring‐closure reactions.